data_9K6P
# 
_entry.id   9K6P 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.404 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9K6P         pdb_00009k6p 10.2210/pdb9k6p/pdb 
WWPDB D_1300052843 ?            ?                   
EMDB  EMD-62131    ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-06-25 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9K6P 
_pdbx_database_status.recvd_initial_deposition_date   2024-10-22 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Cryo-EM Structure of hAGO2D669A-siRNA-target (12-nt)' 
_pdbx_database_related.db_id          EMD-62131 
_pdbx_database_related.content_type   'associated EM volume' 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
3 wujianping@westlake.edu.cn Jianping Wu   ? 'principal investigator/group leader' 0000-0001-9869-7691 
4 shenenzhi@westlake.edu.cn  En-Zhi   Shen ? 'principal investigator/group leader' 0000-0002-6095-7803 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Li, Z.Z.'   1 ? 
'Xu, Q.K.'   2 ? 
'Wu, J.P.'   3 ? 
'Shen, E.Z.' 4 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   CN 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Cell Res.' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1001-0602 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            35 
_citation.language                  ? 
_citation.page_first                453 
_citation.page_last                 464 
_citation.title                     'Mechanistic insights into RNA cleavage by human Argonaute2-siRNA complex.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41422-025-01114-7 
_citation.pdbx_database_id_PubMed   40240484 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Li, Z.'        1  ?                   
primary 'Xu, Q.'        2  ?                   
primary 'Zhang, Y.'     3  0009-0000-0545-1036 
primary 'Zhong, J.'     4  0009-0004-7420-9410 
primary 'Zhang, T.'     5  ?                   
primary 'Xue, J.'       6  ?                   
primary 'Liu, S.'       7  ?                   
primary 'Gao, H.'       8  0000-0002-4954-8793 
primary 'Zhang, Z.Z.Z.' 9  ?                   
primary 'Wu, J.'        10 0000-0001-9869-7691 
primary 'Shen, E.Z.'    11 0000-0002-6095-7803 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'Protein argonaute-2'                           97306.164 1 3.1.26.- D669A ? ? 
2 polymer man 
;RNA (5'-R(P*UP*AP*CP*AP*AP*GP*AP*GP*CP*C)-3')
;
3183.989  1 ?        ?     ? ? 
3 polymer man 
;RNA (5'-R(P*GP*GP*CP*UP*CP*UP*UP*GP*U)-3')
;
2825.687  1 ?        ?     ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        
;Argonaute2,hAgo2,Argonaute RISC catalytic component 2,Eukaryotic translation initiation factor 2C 2,eIF-2C 2,eIF2C 2,PAZ Piwi domain protein,PPD,Protein slicer
;
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)'   no no 
;MYSGAGPALAPPAPPPPIQGYAFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELDIKPEKCPRRVNREIVEHMVQ
HFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKVELEVTLPGEGKDRIFKVSIKWVSCVSLQALHDALSGRLPSVPFETIQ
ALDVVMRHLPSMRYTPVGRSFFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDF
KSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQESGQTVECTVAQYFKDRHKLVL
RYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATARSAPDRQEEISKLMRSASFNTDPYVREFGIM
VKDEMTDVTGRVLQPPSILYGGRNKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRD
AGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQRTTPQTL
SNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQ
DLAAMVRELLIQFYKSTRFKPTRIIFYRAGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCTDK
NERVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQILTYQLCHTYVRCTRSVSIP
APAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDHQALAKAVQVHQDTLRTMYFA
;
;MYSGAGPALAPPAPPPPIQGYAFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELDIKPEKCPRRVNREIVEHMVQ
HFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKVELEVTLPGEGKDRIFKVSIKWVSCVSLQALHDALSGRLPSVPFETIQ
ALDVVMRHLPSMRYTPVGRSFFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDF
KSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQESGQTVECTVAQYFKDRHKLVL
RYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATARSAPDRQEEISKLMRSASFNTDPYVREFGIM
VKDEMTDVTGRVLQPPSILYGGRNKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRD
AGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQRTTPQTL
SNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQ
DLAAMVRELLIQFYKSTRFKPTRIIFYRAGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCTDK
NERVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQILTYQLCHTYVRCTRSVSIP
APAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDHQALAKAVQVHQDTLRTMYFA
;
A ? 
2 polyribonucleotide no no UACAAGAGCC UACAAGAGCC B ? 
3 polyribonucleotide no no GGCUCUUGU GGCUCUUGU C ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   TYR n 
1 3   SER n 
1 4   GLY n 
1 5   ALA n 
1 6   GLY n 
1 7   PRO n 
1 8   ALA n 
1 9   LEU n 
1 10  ALA n 
1 11  PRO n 
1 12  PRO n 
1 13  ALA n 
1 14  PRO n 
1 15  PRO n 
1 16  PRO n 
1 17  PRO n 
1 18  ILE n 
1 19  GLN n 
1 20  GLY n 
1 21  TYR n 
1 22  ALA n 
1 23  PHE n 
1 24  LYS n 
1 25  PRO n 
1 26  PRO n 
1 27  PRO n 
1 28  ARG n 
1 29  PRO n 
1 30  ASP n 
1 31  PHE n 
1 32  GLY n 
1 33  THR n 
1 34  SER n 
1 35  GLY n 
1 36  ARG n 
1 37  THR n 
1 38  ILE n 
1 39  LYS n 
1 40  LEU n 
1 41  GLN n 
1 42  ALA n 
1 43  ASN n 
1 44  PHE n 
1 45  PHE n 
1 46  GLU n 
1 47  MET n 
1 48  ASP n 
1 49  ILE n 
1 50  PRO n 
1 51  LYS n 
1 52  ILE n 
1 53  ASP n 
1 54  ILE n 
1 55  TYR n 
1 56  HIS n 
1 57  TYR n 
1 58  GLU n 
1 59  LEU n 
1 60  ASP n 
1 61  ILE n 
1 62  LYS n 
1 63  PRO n 
1 64  GLU n 
1 65  LYS n 
1 66  CYS n 
1 67  PRO n 
1 68  ARG n 
1 69  ARG n 
1 70  VAL n 
1 71  ASN n 
1 72  ARG n 
1 73  GLU n 
1 74  ILE n 
1 75  VAL n 
1 76  GLU n 
1 77  HIS n 
1 78  MET n 
1 79  VAL n 
1 80  GLN n 
1 81  HIS n 
1 82  PHE n 
1 83  LYS n 
1 84  THR n 
1 85  GLN n 
1 86  ILE n 
1 87  PHE n 
1 88  GLY n 
1 89  ASP n 
1 90  ARG n 
1 91  LYS n 
1 92  PRO n 
1 93  VAL n 
1 94  PHE n 
1 95  ASP n 
1 96  GLY n 
1 97  ARG n 
1 98  LYS n 
1 99  ASN n 
1 100 LEU n 
1 101 TYR n 
1 102 THR n 
1 103 ALA n 
1 104 MET n 
1 105 PRO n 
1 106 LEU n 
1 107 PRO n 
1 108 ILE n 
1 109 GLY n 
1 110 ARG n 
1 111 ASP n 
1 112 LYS n 
1 113 VAL n 
1 114 GLU n 
1 115 LEU n 
1 116 GLU n 
1 117 VAL n 
1 118 THR n 
1 119 LEU n 
1 120 PRO n 
1 121 GLY n 
1 122 GLU n 
1 123 GLY n 
1 124 LYS n 
1 125 ASP n 
1 126 ARG n 
1 127 ILE n 
1 128 PHE n 
1 129 LYS n 
1 130 VAL n 
1 131 SER n 
1 132 ILE n 
1 133 LYS n 
1 134 TRP n 
1 135 VAL n 
1 136 SER n 
1 137 CYS n 
1 138 VAL n 
1 139 SER n 
1 140 LEU n 
1 141 GLN n 
1 142 ALA n 
1 143 LEU n 
1 144 HIS n 
1 145 ASP n 
1 146 ALA n 
1 147 LEU n 
1 148 SER n 
1 149 GLY n 
1 150 ARG n 
1 151 LEU n 
1 152 PRO n 
1 153 SER n 
1 154 VAL n 
1 155 PRO n 
1 156 PHE n 
1 157 GLU n 
1 158 THR n 
1 159 ILE n 
1 160 GLN n 
1 161 ALA n 
1 162 LEU n 
1 163 ASP n 
1 164 VAL n 
1 165 VAL n 
1 166 MET n 
1 167 ARG n 
1 168 HIS n 
1 169 LEU n 
1 170 PRO n 
1 171 SER n 
1 172 MET n 
1 173 ARG n 
1 174 TYR n 
1 175 THR n 
1 176 PRO n 
1 177 VAL n 
1 178 GLY n 
1 179 ARG n 
1 180 SER n 
1 181 PHE n 
1 182 PHE n 
1 183 THR n 
1 184 ALA n 
1 185 SER n 
1 186 GLU n 
1 187 GLY n 
1 188 CYS n 
1 189 SER n 
1 190 ASN n 
1 191 PRO n 
1 192 LEU n 
1 193 GLY n 
1 194 GLY n 
1 195 GLY n 
1 196 ARG n 
1 197 GLU n 
1 198 VAL n 
1 199 TRP n 
1 200 PHE n 
1 201 GLY n 
1 202 PHE n 
1 203 HIS n 
1 204 GLN n 
1 205 SER n 
1 206 VAL n 
1 207 ARG n 
1 208 PRO n 
1 209 SER n 
1 210 LEU n 
1 211 TRP n 
1 212 LYS n 
1 213 MET n 
1 214 MET n 
1 215 LEU n 
1 216 ASN n 
1 217 ILE n 
1 218 ASP n 
1 219 VAL n 
1 220 SER n 
1 221 ALA n 
1 222 THR n 
1 223 ALA n 
1 224 PHE n 
1 225 TYR n 
1 226 LYS n 
1 227 ALA n 
1 228 GLN n 
1 229 PRO n 
1 230 VAL n 
1 231 ILE n 
1 232 GLU n 
1 233 PHE n 
1 234 VAL n 
1 235 CYS n 
1 236 GLU n 
1 237 VAL n 
1 238 LEU n 
1 239 ASP n 
1 240 PHE n 
1 241 LYS n 
1 242 SER n 
1 243 ILE n 
1 244 GLU n 
1 245 GLU n 
1 246 GLN n 
1 247 GLN n 
1 248 LYS n 
1 249 PRO n 
1 250 LEU n 
1 251 THR n 
1 252 ASP n 
1 253 SER n 
1 254 GLN n 
1 255 ARG n 
1 256 VAL n 
1 257 LYS n 
1 258 PHE n 
1 259 THR n 
1 260 LYS n 
1 261 GLU n 
1 262 ILE n 
1 263 LYS n 
1 264 GLY n 
1 265 LEU n 
1 266 LYS n 
1 267 VAL n 
1 268 GLU n 
1 269 ILE n 
1 270 THR n 
1 271 HIS n 
1 272 CYS n 
1 273 GLY n 
1 274 GLN n 
1 275 MET n 
1 276 LYS n 
1 277 ARG n 
1 278 LYS n 
1 279 TYR n 
1 280 ARG n 
1 281 VAL n 
1 282 CYS n 
1 283 ASN n 
1 284 VAL n 
1 285 THR n 
1 286 ARG n 
1 287 ARG n 
1 288 PRO n 
1 289 ALA n 
1 290 SER n 
1 291 HIS n 
1 292 GLN n 
1 293 THR n 
1 294 PHE n 
1 295 PRO n 
1 296 LEU n 
1 297 GLN n 
1 298 GLN n 
1 299 GLU n 
1 300 SER n 
1 301 GLY n 
1 302 GLN n 
1 303 THR n 
1 304 VAL n 
1 305 GLU n 
1 306 CYS n 
1 307 THR n 
1 308 VAL n 
1 309 ALA n 
1 310 GLN n 
1 311 TYR n 
1 312 PHE n 
1 313 LYS n 
1 314 ASP n 
1 315 ARG n 
1 316 HIS n 
1 317 LYS n 
1 318 LEU n 
1 319 VAL n 
1 320 LEU n 
1 321 ARG n 
1 322 TYR n 
1 323 PRO n 
1 324 HIS n 
1 325 LEU n 
1 326 PRO n 
1 327 CYS n 
1 328 LEU n 
1 329 GLN n 
1 330 VAL n 
1 331 GLY n 
1 332 GLN n 
1 333 GLU n 
1 334 GLN n 
1 335 LYS n 
1 336 HIS n 
1 337 THR n 
1 338 TYR n 
1 339 LEU n 
1 340 PRO n 
1 341 LEU n 
1 342 GLU n 
1 343 VAL n 
1 344 CYS n 
1 345 ASN n 
1 346 ILE n 
1 347 VAL n 
1 348 ALA n 
1 349 GLY n 
1 350 GLN n 
1 351 ARG n 
1 352 CYS n 
1 353 ILE n 
1 354 LYS n 
1 355 LYS n 
1 356 LEU n 
1 357 THR n 
1 358 ASP n 
1 359 ASN n 
1 360 GLN n 
1 361 THR n 
1 362 SER n 
1 363 THR n 
1 364 MET n 
1 365 ILE n 
1 366 ARG n 
1 367 ALA n 
1 368 THR n 
1 369 ALA n 
1 370 ARG n 
1 371 SER n 
1 372 ALA n 
1 373 PRO n 
1 374 ASP n 
1 375 ARG n 
1 376 GLN n 
1 377 GLU n 
1 378 GLU n 
1 379 ILE n 
1 380 SER n 
1 381 LYS n 
1 382 LEU n 
1 383 MET n 
1 384 ARG n 
1 385 SER n 
1 386 ALA n 
1 387 SER n 
1 388 PHE n 
1 389 ASN n 
1 390 THR n 
1 391 ASP n 
1 392 PRO n 
1 393 TYR n 
1 394 VAL n 
1 395 ARG n 
1 396 GLU n 
1 397 PHE n 
1 398 GLY n 
1 399 ILE n 
1 400 MET n 
1 401 VAL n 
1 402 LYS n 
1 403 ASP n 
1 404 GLU n 
1 405 MET n 
1 406 THR n 
1 407 ASP n 
1 408 VAL n 
1 409 THR n 
1 410 GLY n 
1 411 ARG n 
1 412 VAL n 
1 413 LEU n 
1 414 GLN n 
1 415 PRO n 
1 416 PRO n 
1 417 SER n 
1 418 ILE n 
1 419 LEU n 
1 420 TYR n 
1 421 GLY n 
1 422 GLY n 
1 423 ARG n 
1 424 ASN n 
1 425 LYS n 
1 426 ALA n 
1 427 ILE n 
1 428 ALA n 
1 429 THR n 
1 430 PRO n 
1 431 VAL n 
1 432 GLN n 
1 433 GLY n 
1 434 VAL n 
1 435 TRP n 
1 436 ASP n 
1 437 MET n 
1 438 ARG n 
1 439 ASN n 
1 440 LYS n 
1 441 GLN n 
1 442 PHE n 
1 443 HIS n 
1 444 THR n 
1 445 GLY n 
1 446 ILE n 
1 447 GLU n 
1 448 ILE n 
1 449 LYS n 
1 450 VAL n 
1 451 TRP n 
1 452 ALA n 
1 453 ILE n 
1 454 ALA n 
1 455 CYS n 
1 456 PHE n 
1 457 ALA n 
1 458 PRO n 
1 459 GLN n 
1 460 ARG n 
1 461 GLN n 
1 462 CYS n 
1 463 THR n 
1 464 GLU n 
1 465 VAL n 
1 466 HIS n 
1 467 LEU n 
1 468 LYS n 
1 469 SER n 
1 470 PHE n 
1 471 THR n 
1 472 GLU n 
1 473 GLN n 
1 474 LEU n 
1 475 ARG n 
1 476 LYS n 
1 477 ILE n 
1 478 SER n 
1 479 ARG n 
1 480 ASP n 
1 481 ALA n 
1 482 GLY n 
1 483 MET n 
1 484 PRO n 
1 485 ILE n 
1 486 GLN n 
1 487 GLY n 
1 488 GLN n 
1 489 PRO n 
1 490 CYS n 
1 491 PHE n 
1 492 CYS n 
1 493 LYS n 
1 494 TYR n 
1 495 ALA n 
1 496 GLN n 
1 497 GLY n 
1 498 ALA n 
1 499 ASP n 
1 500 SER n 
1 501 VAL n 
1 502 GLU n 
1 503 PRO n 
1 504 MET n 
1 505 PHE n 
1 506 ARG n 
1 507 HIS n 
1 508 LEU n 
1 509 LYS n 
1 510 ASN n 
1 511 THR n 
1 512 TYR n 
1 513 ALA n 
1 514 GLY n 
1 515 LEU n 
1 516 GLN n 
1 517 LEU n 
1 518 VAL n 
1 519 VAL n 
1 520 VAL n 
1 521 ILE n 
1 522 LEU n 
1 523 PRO n 
1 524 GLY n 
1 525 LYS n 
1 526 THR n 
1 527 PRO n 
1 528 VAL n 
1 529 TYR n 
1 530 ALA n 
1 531 GLU n 
1 532 VAL n 
1 533 LYS n 
1 534 ARG n 
1 535 VAL n 
1 536 GLY n 
1 537 ASP n 
1 538 THR n 
1 539 VAL n 
1 540 LEU n 
1 541 GLY n 
1 542 MET n 
1 543 ALA n 
1 544 THR n 
1 545 GLN n 
1 546 CYS n 
1 547 VAL n 
1 548 GLN n 
1 549 MET n 
1 550 LYS n 
1 551 ASN n 
1 552 VAL n 
1 553 GLN n 
1 554 ARG n 
1 555 THR n 
1 556 THR n 
1 557 PRO n 
1 558 GLN n 
1 559 THR n 
1 560 LEU n 
1 561 SER n 
1 562 ASN n 
1 563 LEU n 
1 564 CYS n 
1 565 LEU n 
1 566 LYS n 
1 567 ILE n 
1 568 ASN n 
1 569 VAL n 
1 570 LYS n 
1 571 LEU n 
1 572 GLY n 
1 573 GLY n 
1 574 VAL n 
1 575 ASN n 
1 576 ASN n 
1 577 ILE n 
1 578 LEU n 
1 579 LEU n 
1 580 PRO n 
1 581 GLN n 
1 582 GLY n 
1 583 ARG n 
1 584 PRO n 
1 585 PRO n 
1 586 VAL n 
1 587 PHE n 
1 588 GLN n 
1 589 GLN n 
1 590 PRO n 
1 591 VAL n 
1 592 ILE n 
1 593 PHE n 
1 594 LEU n 
1 595 GLY n 
1 596 ALA n 
1 597 ASP n 
1 598 VAL n 
1 599 THR n 
1 600 HIS n 
1 601 PRO n 
1 602 PRO n 
1 603 ALA n 
1 604 GLY n 
1 605 ASP n 
1 606 GLY n 
1 607 LYS n 
1 608 LYS n 
1 609 PRO n 
1 610 SER n 
1 611 ILE n 
1 612 ALA n 
1 613 ALA n 
1 614 VAL n 
1 615 VAL n 
1 616 GLY n 
1 617 SER n 
1 618 MET n 
1 619 ASP n 
1 620 ALA n 
1 621 HIS n 
1 622 PRO n 
1 623 ASN n 
1 624 ARG n 
1 625 TYR n 
1 626 CYS n 
1 627 ALA n 
1 628 THR n 
1 629 VAL n 
1 630 ARG n 
1 631 VAL n 
1 632 GLN n 
1 633 GLN n 
1 634 HIS n 
1 635 ARG n 
1 636 GLN n 
1 637 GLU n 
1 638 ILE n 
1 639 ILE n 
1 640 GLN n 
1 641 ASP n 
1 642 LEU n 
1 643 ALA n 
1 644 ALA n 
1 645 MET n 
1 646 VAL n 
1 647 ARG n 
1 648 GLU n 
1 649 LEU n 
1 650 LEU n 
1 651 ILE n 
1 652 GLN n 
1 653 PHE n 
1 654 TYR n 
1 655 LYS n 
1 656 SER n 
1 657 THR n 
1 658 ARG n 
1 659 PHE n 
1 660 LYS n 
1 661 PRO n 
1 662 THR n 
1 663 ARG n 
1 664 ILE n 
1 665 ILE n 
1 666 PHE n 
1 667 TYR n 
1 668 ARG n 
1 669 ALA n 
1 670 GLY n 
1 671 VAL n 
1 672 SER n 
1 673 GLU n 
1 674 GLY n 
1 675 GLN n 
1 676 PHE n 
1 677 GLN n 
1 678 GLN n 
1 679 VAL n 
1 680 LEU n 
1 681 HIS n 
1 682 HIS n 
1 683 GLU n 
1 684 LEU n 
1 685 LEU n 
1 686 ALA n 
1 687 ILE n 
1 688 ARG n 
1 689 GLU n 
1 690 ALA n 
1 691 CYS n 
1 692 ILE n 
1 693 LYS n 
1 694 LEU n 
1 695 GLU n 
1 696 LYS n 
1 697 ASP n 
1 698 TYR n 
1 699 GLN n 
1 700 PRO n 
1 701 GLY n 
1 702 ILE n 
1 703 THR n 
1 704 PHE n 
1 705 ILE n 
1 706 VAL n 
1 707 VAL n 
1 708 GLN n 
1 709 LYS n 
1 710 ARG n 
1 711 HIS n 
1 712 HIS n 
1 713 THR n 
1 714 ARG n 
1 715 LEU n 
1 716 PHE n 
1 717 CYS n 
1 718 THR n 
1 719 ASP n 
1 720 LYS n 
1 721 ASN n 
1 722 GLU n 
1 723 ARG n 
1 724 VAL n 
1 725 GLY n 
1 726 LYS n 
1 727 SER n 
1 728 GLY n 
1 729 ASN n 
1 730 ILE n 
1 731 PRO n 
1 732 ALA n 
1 733 GLY n 
1 734 THR n 
1 735 THR n 
1 736 VAL n 
1 737 ASP n 
1 738 THR n 
1 739 LYS n 
1 740 ILE n 
1 741 THR n 
1 742 HIS n 
1 743 PRO n 
1 744 THR n 
1 745 GLU n 
1 746 PHE n 
1 747 ASP n 
1 748 PHE n 
1 749 TYR n 
1 750 LEU n 
1 751 CYS n 
1 752 SER n 
1 753 HIS n 
1 754 ALA n 
1 755 GLY n 
1 756 ILE n 
1 757 GLN n 
1 758 GLY n 
1 759 THR n 
1 760 SER n 
1 761 ARG n 
1 762 PRO n 
1 763 SER n 
1 764 HIS n 
1 765 TYR n 
1 766 HIS n 
1 767 VAL n 
1 768 LEU n 
1 769 TRP n 
1 770 ASP n 
1 771 ASP n 
1 772 ASN n 
1 773 ARG n 
1 774 PHE n 
1 775 SER n 
1 776 SER n 
1 777 ASP n 
1 778 GLU n 
1 779 LEU n 
1 780 GLN n 
1 781 ILE n 
1 782 LEU n 
1 783 THR n 
1 784 TYR n 
1 785 GLN n 
1 786 LEU n 
1 787 CYS n 
1 788 HIS n 
1 789 THR n 
1 790 TYR n 
1 791 VAL n 
1 792 ARG n 
1 793 CYS n 
1 794 THR n 
1 795 ARG n 
1 796 SER n 
1 797 VAL n 
1 798 SER n 
1 799 ILE n 
1 800 PRO n 
1 801 ALA n 
1 802 PRO n 
1 803 ALA n 
1 804 TYR n 
1 805 TYR n 
1 806 ALA n 
1 807 HIS n 
1 808 LEU n 
1 809 VAL n 
1 810 ALA n 
1 811 PHE n 
1 812 ARG n 
1 813 ALA n 
1 814 ARG n 
1 815 TYR n 
1 816 HIS n 
1 817 LEU n 
1 818 VAL n 
1 819 ASP n 
1 820 LYS n 
1 821 GLU n 
1 822 HIS n 
1 823 ASP n 
1 824 SER n 
1 825 ALA n 
1 826 GLU n 
1 827 GLY n 
1 828 SER n 
1 829 HIS n 
1 830 THR n 
1 831 SER n 
1 832 GLY n 
1 833 GLN n 
1 834 SER n 
1 835 ASN n 
1 836 GLY n 
1 837 ARG n 
1 838 ASP n 
1 839 HIS n 
1 840 GLN n 
1 841 ALA n 
1 842 LEU n 
1 843 ALA n 
1 844 LYS n 
1 845 ALA n 
1 846 VAL n 
1 847 GLN n 
1 848 VAL n 
1 849 HIS n 
1 850 GLN n 
1 851 ASP n 
1 852 THR n 
1 853 LEU n 
1 854 ARG n 
1 855 THR n 
1 856 MET n 
1 857 TYR n 
1 858 PHE n 
1 859 ALA n 
2 1   U   n 
2 2   A   n 
2 3   C   n 
2 4   A   n 
2 5   A   n 
2 6   G   n 
2 7   A   n 
2 8   G   n 
2 9   C   n 
2 10  C   n 
3 1   G   n 
3 2   G   n 
3 3   C   n 
3 4   U   n 
3 5   C   n 
3 6   U   n 
3 7   U   n 
3 8   G   n 
3 9   U   n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 859 human ? 'AGO2, EIF2C2' ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 'Homo sapiens' 9606 
? ? ? ? ? ? ? ? HEK293 ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 10  ?     ? ?              ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 'Homo sapiens' 9606 
? ? ? ? ? ? ? ? HEK293 ? ? ? ? ? ? ? ? ? ? ? ? 
3 1 sample 'Biological sequence' 1 9   ?     ? ?              ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 'Homo sapiens' 9606 
? ? ? ? ? ? ? ? HEK293 ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A   'RNA linking'       y "ADENOSINE-5'-MONOPHOSPHATE" ? 'C10 H14 N5 O7 P' 347.221 
ALA 'L-peptide linking' y ALANINE                      ? 'C3 H7 N O2'      89.093  
ARG 'L-peptide linking' y ARGININE                     ? 'C6 H15 N4 O2 1'  175.209 
ASN 'L-peptide linking' y ASPARAGINE                   ? 'C4 H8 N2 O3'     132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'              ? 'C4 H7 N O4'      133.103 
C   'RNA linking'       y "CYTIDINE-5'-MONOPHOSPHATE"  ? 'C9 H14 N3 O8 P'  323.197 
CYS 'L-peptide linking' y CYSTEINE                     ? 'C3 H7 N O2 S'    121.158 
G   'RNA linking'       y "GUANOSINE-5'-MONOPHOSPHATE" ? 'C10 H14 N5 O8 P' 363.221 
GLN 'L-peptide linking' y GLUTAMINE                    ? 'C5 H10 N2 O3'    146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'              ? 'C5 H9 N O4'      147.129 
GLY 'peptide linking'   y GLYCINE                      ? 'C2 H5 N O2'      75.067  
HIS 'L-peptide linking' y HISTIDINE                    ? 'C6 H10 N3 O2 1'  156.162 
ILE 'L-peptide linking' y ISOLEUCINE                   ? 'C6 H13 N O2'     131.173 
LEU 'L-peptide linking' y LEUCINE                      ? 'C6 H13 N O2'     131.173 
LYS 'L-peptide linking' y LYSINE                       ? 'C6 H15 N2 O2 1'  147.195 
MET 'L-peptide linking' y METHIONINE                   ? 'C5 H11 N O2 S'   149.211 
PHE 'L-peptide linking' y PHENYLALANINE                ? 'C9 H11 N O2'     165.189 
PRO 'L-peptide linking' y PROLINE                      ? 'C5 H9 N O2'      115.130 
SER 'L-peptide linking' y SERINE                       ? 'C3 H7 N O3'      105.093 
THR 'L-peptide linking' y THREONINE                    ? 'C4 H9 N O3'      119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                   ? 'C11 H12 N2 O2'   204.225 
TYR 'L-peptide linking' y TYROSINE                     ? 'C9 H11 N O3'     181.189 
U   'RNA linking'       y "URIDINE-5'-MONOPHOSPHATE"   ? 'C9 H13 N2 O9 P'  324.181 
VAL 'L-peptide linking' y VALINE                       ? 'C5 H11 N O2'     117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   TYR 2   2   ?   ?   ?   A . n 
A 1 3   SER 3   3   ?   ?   ?   A . n 
A 1 4   GLY 4   4   ?   ?   ?   A . n 
A 1 5   ALA 5   5   ?   ?   ?   A . n 
A 1 6   GLY 6   6   ?   ?   ?   A . n 
A 1 7   PRO 7   7   ?   ?   ?   A . n 
A 1 8   ALA 8   8   ?   ?   ?   A . n 
A 1 9   LEU 9   9   ?   ?   ?   A . n 
A 1 10  ALA 10  10  ?   ?   ?   A . n 
A 1 11  PRO 11  11  ?   ?   ?   A . n 
A 1 12  PRO 12  12  ?   ?   ?   A . n 
A 1 13  ALA 13  13  ?   ?   ?   A . n 
A 1 14  PRO 14  14  ?   ?   ?   A . n 
A 1 15  PRO 15  15  ?   ?   ?   A . n 
A 1 16  PRO 16  16  ?   ?   ?   A . n 
A 1 17  PRO 17  17  ?   ?   ?   A . n 
A 1 18  ILE 18  18  ?   ?   ?   A . n 
A 1 19  GLN 19  19  ?   ?   ?   A . n 
A 1 20  GLY 20  20  20  GLY GLY A . n 
A 1 21  TYR 21  21  21  TYR TYR A . n 
A 1 22  ALA 22  22  22  ALA ALA A . n 
A 1 23  PHE 23  23  23  PHE PHE A . n 
A 1 24  LYS 24  24  24  LYS LYS A . n 
A 1 25  PRO 25  25  25  PRO PRO A . n 
A 1 26  PRO 26  26  26  PRO PRO A . n 
A 1 27  PRO 27  27  27  PRO PRO A . n 
A 1 28  ARG 28  28  28  ARG ARG A . n 
A 1 29  PRO 29  29  29  PRO PRO A . n 
A 1 30  ASP 30  30  30  ASP ASP A . n 
A 1 31  PHE 31  31  31  PHE PHE A . n 
A 1 32  GLY 32  32  32  GLY GLY A . n 
A 1 33  THR 33  33  33  THR THR A . n 
A 1 34  SER 34  34  34  SER SER A . n 
A 1 35  GLY 35  35  35  GLY GLY A . n 
A 1 36  ARG 36  36  36  ARG ARG A . n 
A 1 37  THR 37  37  37  THR THR A . n 
A 1 38  ILE 38  38  38  ILE ILE A . n 
A 1 39  LYS 39  39  39  LYS LYS A . n 
A 1 40  LEU 40  40  40  LEU LEU A . n 
A 1 41  GLN 41  41  41  GLN GLN A . n 
A 1 42  ALA 42  42  42  ALA ALA A . n 
A 1 43  ASN 43  43  43  ASN ASN A . n 
A 1 44  PHE 44  44  44  PHE PHE A . n 
A 1 45  PHE 45  45  45  PHE PHE A . n 
A 1 46  GLU 46  46  46  GLU GLU A . n 
A 1 47  MET 47  47  47  MET MET A . n 
A 1 48  ASP 48  48  48  ASP ASP A . n 
A 1 49  ILE 49  49  49  ILE ILE A . n 
A 1 50  PRO 50  50  50  PRO PRO A . n 
A 1 51  LYS 51  51  51  LYS LYS A . n 
A 1 52  ILE 52  52  52  ILE ILE A . n 
A 1 53  ASP 53  53  53  ASP ASP A . n 
A 1 54  ILE 54  54  54  ILE ILE A . n 
A 1 55  TYR 55  55  55  TYR TYR A . n 
A 1 56  HIS 56  56  56  HIS HIS A . n 
A 1 57  TYR 57  57  57  TYR TYR A . n 
A 1 58  GLU 58  58  58  GLU GLU A . n 
A 1 59  LEU 59  59  59  LEU LEU A . n 
A 1 60  ASP 60  60  60  ASP ASP A . n 
A 1 61  ILE 61  61  61  ILE ILE A . n 
A 1 62  LYS 62  62  62  LYS LYS A . n 
A 1 63  PRO 63  63  63  PRO PRO A . n 
A 1 64  GLU 64  64  64  GLU GLU A . n 
A 1 65  LYS 65  65  65  LYS LYS A . n 
A 1 66  CYS 66  66  66  CYS CYS A . n 
A 1 67  PRO 67  67  67  PRO PRO A . n 
A 1 68  ARG 68  68  68  ARG ARG A . n 
A 1 69  ARG 69  69  69  ARG ARG A . n 
A 1 70  VAL 70  70  70  VAL VAL A . n 
A 1 71  ASN 71  71  71  ASN ASN A . n 
A 1 72  ARG 72  72  72  ARG ARG A . n 
A 1 73  GLU 73  73  73  GLU GLU A . n 
A 1 74  ILE 74  74  74  ILE ILE A . n 
A 1 75  VAL 75  75  75  VAL VAL A . n 
A 1 76  GLU 76  76  76  GLU GLU A . n 
A 1 77  HIS 77  77  77  HIS HIS A . n 
A 1 78  MET 78  78  78  MET MET A . n 
A 1 79  VAL 79  79  79  VAL VAL A . n 
A 1 80  GLN 80  80  80  GLN GLN A . n 
A 1 81  HIS 81  81  81  HIS HIS A . n 
A 1 82  PHE 82  82  82  PHE PHE A . n 
A 1 83  LYS 83  83  83  LYS LYS A . n 
A 1 84  THR 84  84  84  THR THR A . n 
A 1 85  GLN 85  85  85  GLN GLN A . n 
A 1 86  ILE 86  86  86  ILE ILE A . n 
A 1 87  PHE 87  87  87  PHE PHE A . n 
A 1 88  GLY 88  88  88  GLY GLY A . n 
A 1 89  ASP 89  89  89  ASP ASP A . n 
A 1 90  ARG 90  90  90  ARG ARG A . n 
A 1 91  LYS 91  91  91  LYS LYS A . n 
A 1 92  PRO 92  92  92  PRO PRO A . n 
A 1 93  VAL 93  93  93  VAL VAL A . n 
A 1 94  PHE 94  94  94  PHE PHE A . n 
A 1 95  ASP 95  95  95  ASP ASP A . n 
A 1 96  GLY 96  96  96  GLY GLY A . n 
A 1 97  ARG 97  97  97  ARG ARG A . n 
A 1 98  LYS 98  98  98  LYS LYS A . n 
A 1 99  ASN 99  99  99  ASN ASN A . n 
A 1 100 LEU 100 100 100 LEU LEU A . n 
A 1 101 TYR 101 101 101 TYR TYR A . n 
A 1 102 THR 102 102 102 THR THR A . n 
A 1 103 ALA 103 103 103 ALA ALA A . n 
A 1 104 MET 104 104 104 MET MET A . n 
A 1 105 PRO 105 105 105 PRO PRO A . n 
A 1 106 LEU 106 106 106 LEU LEU A . n 
A 1 107 PRO 107 107 107 PRO PRO A . n 
A 1 108 ILE 108 108 108 ILE ILE A . n 
A 1 109 GLY 109 109 109 GLY GLY A . n 
A 1 110 ARG 110 110 110 ARG ARG A . n 
A 1 111 ASP 111 111 111 ASP ASP A . n 
A 1 112 LYS 112 112 112 LYS LYS A . n 
A 1 113 VAL 113 113 113 VAL VAL A . n 
A 1 114 GLU 114 114 114 GLU GLU A . n 
A 1 115 LEU 115 115 115 LEU LEU A . n 
A 1 116 GLU 116 116 116 GLU GLU A . n 
A 1 117 VAL 117 117 117 VAL VAL A . n 
A 1 118 THR 118 118 118 THR THR A . n 
A 1 119 LEU 119 119 119 LEU LEU A . n 
A 1 120 PRO 120 120 120 PRO PRO A . n 
A 1 121 GLY 121 121 121 GLY GLY A . n 
A 1 122 GLU 122 122 122 GLU GLU A . n 
A 1 123 GLY 123 123 123 GLY GLY A . n 
A 1 124 LYS 124 124 124 LYS LYS A . n 
A 1 125 ASP 125 125 125 ASP ASP A . n 
A 1 126 ARG 126 126 126 ARG ARG A . n 
A 1 127 ILE 127 127 127 ILE ILE A . n 
A 1 128 PHE 128 128 128 PHE PHE A . n 
A 1 129 LYS 129 129 129 LYS LYS A . n 
A 1 130 VAL 130 130 130 VAL VAL A . n 
A 1 131 SER 131 131 131 SER SER A . n 
A 1 132 ILE 132 132 132 ILE ILE A . n 
A 1 133 LYS 133 133 133 LYS LYS A . n 
A 1 134 TRP 134 134 134 TRP TRP A . n 
A 1 135 VAL 135 135 135 VAL VAL A . n 
A 1 136 SER 136 136 136 SER SER A . n 
A 1 137 CYS 137 137 137 CYS CYS A . n 
A 1 138 VAL 138 138 138 VAL VAL A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 LEU 140 140 140 LEU LEU A . n 
A 1 141 GLN 141 141 141 GLN GLN A . n 
A 1 142 ALA 142 142 142 ALA ALA A . n 
A 1 143 LEU 143 143 143 LEU LEU A . n 
A 1 144 HIS 144 144 144 HIS HIS A . n 
A 1 145 ASP 145 145 145 ASP ASP A . n 
A 1 146 ALA 146 146 146 ALA ALA A . n 
A 1 147 LEU 147 147 147 LEU LEU A . n 
A 1 148 SER 148 148 148 SER SER A . n 
A 1 149 GLY 149 149 149 GLY GLY A . n 
A 1 150 ARG 150 150 150 ARG ARG A . n 
A 1 151 LEU 151 151 151 LEU LEU A . n 
A 1 152 PRO 152 152 152 PRO PRO A . n 
A 1 153 SER 153 153 153 SER SER A . n 
A 1 154 VAL 154 154 154 VAL VAL A . n 
A 1 155 PRO 155 155 155 PRO PRO A . n 
A 1 156 PHE 156 156 156 PHE PHE A . n 
A 1 157 GLU 157 157 157 GLU GLU A . n 
A 1 158 THR 158 158 158 THR THR A . n 
A 1 159 ILE 159 159 159 ILE ILE A . n 
A 1 160 GLN 160 160 160 GLN GLN A . n 
A 1 161 ALA 161 161 161 ALA ALA A . n 
A 1 162 LEU 162 162 162 LEU LEU A . n 
A 1 163 ASP 163 163 163 ASP ASP A . n 
A 1 164 VAL 164 164 164 VAL VAL A . n 
A 1 165 VAL 165 165 165 VAL VAL A . n 
A 1 166 MET 166 166 166 MET MET A . n 
A 1 167 ARG 167 167 167 ARG ARG A . n 
A 1 168 HIS 168 168 168 HIS HIS A . n 
A 1 169 LEU 169 169 169 LEU LEU A . n 
A 1 170 PRO 170 170 170 PRO PRO A . n 
A 1 171 SER 171 171 171 SER SER A . n 
A 1 172 MET 172 172 172 MET MET A . n 
A 1 173 ARG 173 173 173 ARG ARG A . n 
A 1 174 TYR 174 174 174 TYR TYR A . n 
A 1 175 THR 175 175 175 THR THR A . n 
A 1 176 PRO 176 176 176 PRO PRO A . n 
A 1 177 VAL 177 177 177 VAL VAL A . n 
A 1 178 GLY 178 178 178 GLY GLY A . n 
A 1 179 ARG 179 179 179 ARG ARG A . n 
A 1 180 SER 180 180 180 SER SER A . n 
A 1 181 PHE 181 181 181 PHE PHE A . n 
A 1 182 PHE 182 182 182 PHE PHE A . n 
A 1 183 THR 183 183 183 THR THR A . n 
A 1 184 ALA 184 184 184 ALA ALA A . n 
A 1 185 SER 185 185 185 SER SER A . n 
A 1 186 GLU 186 186 186 GLU GLU A . n 
A 1 187 GLY 187 187 187 GLY GLY A . n 
A 1 188 CYS 188 188 188 CYS CYS A . n 
A 1 189 SER 189 189 189 SER SER A . n 
A 1 190 ASN 190 190 190 ASN ASN A . n 
A 1 191 PRO 191 191 191 PRO PRO A . n 
A 1 192 LEU 192 192 192 LEU LEU A . n 
A 1 193 GLY 193 193 193 GLY GLY A . n 
A 1 194 GLY 194 194 194 GLY GLY A . n 
A 1 195 GLY 195 195 195 GLY GLY A . n 
A 1 196 ARG 196 196 196 ARG ARG A . n 
A 1 197 GLU 197 197 197 GLU GLU A . n 
A 1 198 VAL 198 198 198 VAL VAL A . n 
A 1 199 TRP 199 199 199 TRP TRP A . n 
A 1 200 PHE 200 200 200 PHE PHE A . n 
A 1 201 GLY 201 201 201 GLY GLY A . n 
A 1 202 PHE 202 202 202 PHE PHE A . n 
A 1 203 HIS 203 203 203 HIS HIS A . n 
A 1 204 GLN 204 204 204 GLN GLN A . n 
A 1 205 SER 205 205 205 SER SER A . n 
A 1 206 VAL 206 206 206 VAL VAL A . n 
A 1 207 ARG 207 207 207 ARG ARG A . n 
A 1 208 PRO 208 208 208 PRO PRO A . n 
A 1 209 SER 209 209 209 SER SER A . n 
A 1 210 LEU 210 210 210 LEU LEU A . n 
A 1 211 TRP 211 211 211 TRP TRP A . n 
A 1 212 LYS 212 212 212 LYS LYS A . n 
A 1 213 MET 213 213 213 MET MET A . n 
A 1 214 MET 214 214 214 MET MET A . n 
A 1 215 LEU 215 215 215 LEU LEU A . n 
A 1 216 ASN 216 216 216 ASN ASN A . n 
A 1 217 ILE 217 217 217 ILE ILE A . n 
A 1 218 ASP 218 218 218 ASP ASP A . n 
A 1 219 VAL 219 219 219 VAL VAL A . n 
A 1 220 SER 220 220 220 SER SER A . n 
A 1 221 ALA 221 221 221 ALA ALA A . n 
A 1 222 THR 222 222 222 THR THR A . n 
A 1 223 ALA 223 223 223 ALA ALA A . n 
A 1 224 PHE 224 224 224 PHE PHE A . n 
A 1 225 TYR 225 225 225 TYR TYR A . n 
A 1 226 LYS 226 226 226 LYS LYS A . n 
A 1 227 ALA 227 227 227 ALA ALA A . n 
A 1 228 GLN 228 228 228 GLN GLN A . n 
A 1 229 PRO 229 229 229 PRO PRO A . n 
A 1 230 VAL 230 230 230 VAL VAL A . n 
A 1 231 ILE 231 231 231 ILE ILE A . n 
A 1 232 GLU 232 232 232 GLU GLU A . n 
A 1 233 PHE 233 233 233 PHE PHE A . n 
A 1 234 VAL 234 234 234 VAL VAL A . n 
A 1 235 CYS 235 235 235 CYS CYS A . n 
A 1 236 GLU 236 236 236 GLU GLU A . n 
A 1 237 VAL 237 237 237 VAL VAL A . n 
A 1 238 LEU 238 238 238 LEU LEU A . n 
A 1 239 ASP 239 239 239 ASP ASP A . n 
A 1 240 PHE 240 240 240 PHE PHE A . n 
A 1 241 LYS 241 241 241 LYS LYS A . n 
A 1 242 SER 242 242 242 SER SER A . n 
A 1 243 ILE 243 243 243 ILE ILE A . n 
A 1 244 GLU 244 244 244 GLU GLU A . n 
A 1 245 GLU 245 245 245 GLU GLU A . n 
A 1 246 GLN 246 246 246 GLN GLN A . n 
A 1 247 GLN 247 247 247 GLN GLN A . n 
A 1 248 LYS 248 248 248 LYS LYS A . n 
A 1 249 PRO 249 249 249 PRO PRO A . n 
A 1 250 LEU 250 250 250 LEU LEU A . n 
A 1 251 THR 251 251 251 THR THR A . n 
A 1 252 ASP 252 252 252 ASP ASP A . n 
A 1 253 SER 253 253 253 SER SER A . n 
A 1 254 GLN 254 254 254 GLN GLN A . n 
A 1 255 ARG 255 255 255 ARG ARG A . n 
A 1 256 VAL 256 256 256 VAL VAL A . n 
A 1 257 LYS 257 257 257 LYS LYS A . n 
A 1 258 PHE 258 258 258 PHE PHE A . n 
A 1 259 THR 259 259 259 THR THR A . n 
A 1 260 LYS 260 260 260 LYS LYS A . n 
A 1 261 GLU 261 261 261 GLU GLU A . n 
A 1 262 ILE 262 262 262 ILE ILE A . n 
A 1 263 LYS 263 263 263 LYS LYS A . n 
A 1 264 GLY 264 264 264 GLY GLY A . n 
A 1 265 LEU 265 265 265 LEU LEU A . n 
A 1 266 LYS 266 266 266 LYS LYS A . n 
A 1 267 VAL 267 267 267 VAL VAL A . n 
A 1 268 GLU 268 268 268 GLU GLU A . n 
A 1 269 ILE 269 269 269 ILE ILE A . n 
A 1 270 THR 270 270 270 THR THR A . n 
A 1 271 HIS 271 271 271 HIS HIS A . n 
A 1 272 CYS 272 272 272 CYS CYS A . n 
A 1 273 GLY 273 273 273 GLY GLY A . n 
A 1 274 GLN 274 274 274 GLN GLN A . n 
A 1 275 MET 275 275 275 MET MET A . n 
A 1 276 LYS 276 276 276 LYS LYS A . n 
A 1 277 ARG 277 277 277 ARG ARG A . n 
A 1 278 LYS 278 278 278 LYS LYS A . n 
A 1 279 TYR 279 279 279 TYR TYR A . n 
A 1 280 ARG 280 280 280 ARG ARG A . n 
A 1 281 VAL 281 281 281 VAL VAL A . n 
A 1 282 CYS 282 282 282 CYS CYS A . n 
A 1 283 ASN 283 283 283 ASN ASN A . n 
A 1 284 VAL 284 284 284 VAL VAL A . n 
A 1 285 THR 285 285 ?   ?   ?   A . n 
A 1 286 ARG 286 286 ?   ?   ?   A . n 
A 1 287 ARG 287 287 ?   ?   ?   A . n 
A 1 288 PRO 288 288 ?   ?   ?   A . n 
A 1 289 ALA 289 289 ?   ?   ?   A . n 
A 1 290 SER 290 290 ?   ?   ?   A . n 
A 1 291 HIS 291 291 ?   ?   ?   A . n 
A 1 292 GLN 292 292 ?   ?   ?   A . n 
A 1 293 THR 293 293 ?   ?   ?   A . n 
A 1 294 PHE 294 294 ?   ?   ?   A . n 
A 1 295 PRO 295 295 ?   ?   ?   A . n 
A 1 296 LEU 296 296 ?   ?   ?   A . n 
A 1 297 GLN 297 297 ?   ?   ?   A . n 
A 1 298 GLN 298 298 ?   ?   ?   A . n 
A 1 299 GLU 299 299 ?   ?   ?   A . n 
A 1 300 SER 300 300 ?   ?   ?   A . n 
A 1 301 GLY 301 301 ?   ?   ?   A . n 
A 1 302 GLN 302 302 ?   ?   ?   A . n 
A 1 303 THR 303 303 ?   ?   ?   A . n 
A 1 304 VAL 304 304 ?   ?   ?   A . n 
A 1 305 GLU 305 305 ?   ?   ?   A . n 
A 1 306 CYS 306 306 ?   ?   ?   A . n 
A 1 307 THR 307 307 ?   ?   ?   A . n 
A 1 308 VAL 308 308 ?   ?   ?   A . n 
A 1 309 ALA 309 309 ?   ?   ?   A . n 
A 1 310 GLN 310 310 ?   ?   ?   A . n 
A 1 311 TYR 311 311 ?   ?   ?   A . n 
A 1 312 PHE 312 312 ?   ?   ?   A . n 
A 1 313 LYS 313 313 ?   ?   ?   A . n 
A 1 314 ASP 314 314 ?   ?   ?   A . n 
A 1 315 ARG 315 315 ?   ?   ?   A . n 
A 1 316 HIS 316 316 ?   ?   ?   A . n 
A 1 317 LYS 317 317 ?   ?   ?   A . n 
A 1 318 LEU 318 318 ?   ?   ?   A . n 
A 1 319 VAL 319 319 ?   ?   ?   A . n 
A 1 320 LEU 320 320 ?   ?   ?   A . n 
A 1 321 ARG 321 321 ?   ?   ?   A . n 
A 1 322 TYR 322 322 ?   ?   ?   A . n 
A 1 323 PRO 323 323 ?   ?   ?   A . n 
A 1 324 HIS 324 324 ?   ?   ?   A . n 
A 1 325 LEU 325 325 ?   ?   ?   A . n 
A 1 326 PRO 326 326 ?   ?   ?   A . n 
A 1 327 CYS 327 327 ?   ?   ?   A . n 
A 1 328 LEU 328 328 328 LEU LEU A . n 
A 1 329 GLN 329 329 329 GLN GLN A . n 
A 1 330 VAL 330 330 330 VAL VAL A . n 
A 1 331 GLY 331 331 331 GLY GLY A . n 
A 1 332 GLN 332 332 332 GLN GLN A . n 
A 1 333 GLU 333 333 333 GLU GLU A . n 
A 1 334 GLN 334 334 334 GLN GLN A . n 
A 1 335 LYS 335 335 335 LYS LYS A . n 
A 1 336 HIS 336 336 336 HIS HIS A . n 
A 1 337 THR 337 337 337 THR THR A . n 
A 1 338 TYR 338 338 338 TYR TYR A . n 
A 1 339 LEU 339 339 339 LEU LEU A . n 
A 1 340 PRO 340 340 340 PRO PRO A . n 
A 1 341 LEU 341 341 341 LEU LEU A . n 
A 1 342 GLU 342 342 342 GLU GLU A . n 
A 1 343 VAL 343 343 343 VAL VAL A . n 
A 1 344 CYS 344 344 344 CYS CYS A . n 
A 1 345 ASN 345 345 345 ASN ASN A . n 
A 1 346 ILE 346 346 346 ILE ILE A . n 
A 1 347 VAL 347 347 347 VAL VAL A . n 
A 1 348 ALA 348 348 348 ALA ALA A . n 
A 1 349 GLY 349 349 349 GLY GLY A . n 
A 1 350 GLN 350 350 350 GLN GLN A . n 
A 1 351 ARG 351 351 351 ARG ARG A . n 
A 1 352 CYS 352 352 352 CYS CYS A . n 
A 1 353 ILE 353 353 353 ILE ILE A . n 
A 1 354 LYS 354 354 354 LYS LYS A . n 
A 1 355 LYS 355 355 355 LYS LYS A . n 
A 1 356 LEU 356 356 356 LEU LEU A . n 
A 1 357 THR 357 357 357 THR THR A . n 
A 1 358 ASP 358 358 358 ASP ASP A . n 
A 1 359 ASN 359 359 359 ASN ASN A . n 
A 1 360 GLN 360 360 360 GLN GLN A . n 
A 1 361 THR 361 361 361 THR THR A . n 
A 1 362 SER 362 362 362 SER SER A . n 
A 1 363 THR 363 363 363 THR THR A . n 
A 1 364 MET 364 364 364 MET MET A . n 
A 1 365 ILE 365 365 365 ILE ILE A . n 
A 1 366 ARG 366 366 366 ARG ARG A . n 
A 1 367 ALA 367 367 367 ALA ALA A . n 
A 1 368 THR 368 368 368 THR THR A . n 
A 1 369 ALA 369 369 369 ALA ALA A . n 
A 1 370 ARG 370 370 370 ARG ARG A . n 
A 1 371 SER 371 371 371 SER SER A . n 
A 1 372 ALA 372 372 372 ALA ALA A . n 
A 1 373 PRO 373 373 373 PRO PRO A . n 
A 1 374 ASP 374 374 374 ASP ASP A . n 
A 1 375 ARG 375 375 375 ARG ARG A . n 
A 1 376 GLN 376 376 376 GLN GLN A . n 
A 1 377 GLU 377 377 377 GLU GLU A . n 
A 1 378 GLU 378 378 378 GLU GLU A . n 
A 1 379 ILE 379 379 379 ILE ILE A . n 
A 1 380 SER 380 380 380 SER SER A . n 
A 1 381 LYS 381 381 381 LYS LYS A . n 
A 1 382 LEU 382 382 382 LEU LEU A . n 
A 1 383 MET 383 383 383 MET MET A . n 
A 1 384 ARG 384 384 384 ARG ARG A . n 
A 1 385 SER 385 385 385 SER SER A . n 
A 1 386 ALA 386 386 386 ALA ALA A . n 
A 1 387 SER 387 387 387 SER SER A . n 
A 1 388 PHE 388 388 388 PHE PHE A . n 
A 1 389 ASN 389 389 389 ASN ASN A . n 
A 1 390 THR 390 390 390 THR THR A . n 
A 1 391 ASP 391 391 391 ASP ASP A . n 
A 1 392 PRO 392 392 392 PRO PRO A . n 
A 1 393 TYR 393 393 393 TYR TYR A . n 
A 1 394 VAL 394 394 394 VAL VAL A . n 
A 1 395 ARG 395 395 395 ARG ARG A . n 
A 1 396 GLU 396 396 396 GLU GLU A . n 
A 1 397 PHE 397 397 397 PHE PHE A . n 
A 1 398 GLY 398 398 398 GLY GLY A . n 
A 1 399 ILE 399 399 399 ILE ILE A . n 
A 1 400 MET 400 400 400 MET MET A . n 
A 1 401 VAL 401 401 401 VAL VAL A . n 
A 1 402 LYS 402 402 402 LYS LYS A . n 
A 1 403 ASP 403 403 403 ASP ASP A . n 
A 1 404 GLU 404 404 404 GLU GLU A . n 
A 1 405 MET 405 405 405 MET MET A . n 
A 1 406 THR 406 406 406 THR THR A . n 
A 1 407 ASP 407 407 407 ASP ASP A . n 
A 1 408 VAL 408 408 408 VAL VAL A . n 
A 1 409 THR 409 409 409 THR THR A . n 
A 1 410 GLY 410 410 410 GLY GLY A . n 
A 1 411 ARG 411 411 411 ARG ARG A . n 
A 1 412 VAL 412 412 412 VAL VAL A . n 
A 1 413 LEU 413 413 413 LEU LEU A . n 
A 1 414 GLN 414 414 414 GLN GLN A . n 
A 1 415 PRO 415 415 415 PRO PRO A . n 
A 1 416 PRO 416 416 416 PRO PRO A . n 
A 1 417 SER 417 417 417 SER SER A . n 
A 1 418 ILE 418 418 418 ILE ILE A . n 
A 1 419 LEU 419 419 419 LEU LEU A . n 
A 1 420 TYR 420 420 420 TYR TYR A . n 
A 1 421 GLY 421 421 421 GLY GLY A . n 
A 1 422 GLY 422 422 422 GLY GLY A . n 
A 1 423 ARG 423 423 423 ARG ARG A . n 
A 1 424 ASN 424 424 424 ASN ASN A . n 
A 1 425 LYS 425 425 425 LYS LYS A . n 
A 1 426 ALA 426 426 426 ALA ALA A . n 
A 1 427 ILE 427 427 427 ILE ILE A . n 
A 1 428 ALA 428 428 428 ALA ALA A . n 
A 1 429 THR 429 429 429 THR THR A . n 
A 1 430 PRO 430 430 430 PRO PRO A . n 
A 1 431 VAL 431 431 431 VAL VAL A . n 
A 1 432 GLN 432 432 432 GLN GLN A . n 
A 1 433 GLY 433 433 433 GLY GLY A . n 
A 1 434 VAL 434 434 434 VAL VAL A . n 
A 1 435 TRP 435 435 435 TRP TRP A . n 
A 1 436 ASP 436 436 436 ASP ASP A . n 
A 1 437 MET 437 437 437 MET MET A . n 
A 1 438 ARG 438 438 438 ARG ARG A . n 
A 1 439 ASN 439 439 439 ASN ASN A . n 
A 1 440 LYS 440 440 440 LYS LYS A . n 
A 1 441 GLN 441 441 441 GLN GLN A . n 
A 1 442 PHE 442 442 442 PHE PHE A . n 
A 1 443 HIS 443 443 443 HIS HIS A . n 
A 1 444 THR 444 444 444 THR THR A . n 
A 1 445 GLY 445 445 445 GLY GLY A . n 
A 1 446 ILE 446 446 446 ILE ILE A . n 
A 1 447 GLU 447 447 447 GLU GLU A . n 
A 1 448 ILE 448 448 448 ILE ILE A . n 
A 1 449 LYS 449 449 449 LYS LYS A . n 
A 1 450 VAL 450 450 450 VAL VAL A . n 
A 1 451 TRP 451 451 451 TRP TRP A . n 
A 1 452 ALA 452 452 452 ALA ALA A . n 
A 1 453 ILE 453 453 453 ILE ILE A . n 
A 1 454 ALA 454 454 454 ALA ALA A . n 
A 1 455 CYS 455 455 455 CYS CYS A . n 
A 1 456 PHE 456 456 456 PHE PHE A . n 
A 1 457 ALA 457 457 457 ALA ALA A . n 
A 1 458 PRO 458 458 458 PRO PRO A . n 
A 1 459 GLN 459 459 459 GLN GLN A . n 
A 1 460 ARG 460 460 460 ARG ARG A . n 
A 1 461 GLN 461 461 461 GLN GLN A . n 
A 1 462 CYS 462 462 462 CYS CYS A . n 
A 1 463 THR 463 463 463 THR THR A . n 
A 1 464 GLU 464 464 464 GLU GLU A . n 
A 1 465 VAL 465 465 465 VAL VAL A . n 
A 1 466 HIS 466 466 466 HIS HIS A . n 
A 1 467 LEU 467 467 467 LEU LEU A . n 
A 1 468 LYS 468 468 468 LYS LYS A . n 
A 1 469 SER 469 469 469 SER SER A . n 
A 1 470 PHE 470 470 470 PHE PHE A . n 
A 1 471 THR 471 471 471 THR THR A . n 
A 1 472 GLU 472 472 472 GLU GLU A . n 
A 1 473 GLN 473 473 473 GLN GLN A . n 
A 1 474 LEU 474 474 474 LEU LEU A . n 
A 1 475 ARG 475 475 475 ARG ARG A . n 
A 1 476 LYS 476 476 476 LYS LYS A . n 
A 1 477 ILE 477 477 477 ILE ILE A . n 
A 1 478 SER 478 478 478 SER SER A . n 
A 1 479 ARG 479 479 479 ARG ARG A . n 
A 1 480 ASP 480 480 480 ASP ASP A . n 
A 1 481 ALA 481 481 481 ALA ALA A . n 
A 1 482 GLY 482 482 482 GLY GLY A . n 
A 1 483 MET 483 483 483 MET MET A . n 
A 1 484 PRO 484 484 484 PRO PRO A . n 
A 1 485 ILE 485 485 485 ILE ILE A . n 
A 1 486 GLN 486 486 486 GLN GLN A . n 
A 1 487 GLY 487 487 487 GLY GLY A . n 
A 1 488 GLN 488 488 488 GLN GLN A . n 
A 1 489 PRO 489 489 489 PRO PRO A . n 
A 1 490 CYS 490 490 490 CYS CYS A . n 
A 1 491 PHE 491 491 491 PHE PHE A . n 
A 1 492 CYS 492 492 492 CYS CYS A . n 
A 1 493 LYS 493 493 493 LYS LYS A . n 
A 1 494 TYR 494 494 494 TYR TYR A . n 
A 1 495 ALA 495 495 495 ALA ALA A . n 
A 1 496 GLN 496 496 496 GLN GLN A . n 
A 1 497 GLY 497 497 497 GLY GLY A . n 
A 1 498 ALA 498 498 498 ALA ALA A . n 
A 1 499 ASP 499 499 499 ASP ASP A . n 
A 1 500 SER 500 500 500 SER SER A . n 
A 1 501 VAL 501 501 501 VAL VAL A . n 
A 1 502 GLU 502 502 502 GLU GLU A . n 
A 1 503 PRO 503 503 503 PRO PRO A . n 
A 1 504 MET 504 504 504 MET MET A . n 
A 1 505 PHE 505 505 505 PHE PHE A . n 
A 1 506 ARG 506 506 506 ARG ARG A . n 
A 1 507 HIS 507 507 507 HIS HIS A . n 
A 1 508 LEU 508 508 508 LEU LEU A . n 
A 1 509 LYS 509 509 509 LYS LYS A . n 
A 1 510 ASN 510 510 510 ASN ASN A . n 
A 1 511 THR 511 511 511 THR THR A . n 
A 1 512 TYR 512 512 512 TYR TYR A . n 
A 1 513 ALA 513 513 513 ALA ALA A . n 
A 1 514 GLY 514 514 514 GLY GLY A . n 
A 1 515 LEU 515 515 515 LEU LEU A . n 
A 1 516 GLN 516 516 516 GLN GLN A . n 
A 1 517 LEU 517 517 517 LEU LEU A . n 
A 1 518 VAL 518 518 518 VAL VAL A . n 
A 1 519 VAL 519 519 519 VAL VAL A . n 
A 1 520 VAL 520 520 520 VAL VAL A . n 
A 1 521 ILE 521 521 521 ILE ILE A . n 
A 1 522 LEU 522 522 522 LEU LEU A . n 
A 1 523 PRO 523 523 523 PRO PRO A . n 
A 1 524 GLY 524 524 524 GLY GLY A . n 
A 1 525 LYS 525 525 525 LYS LYS A . n 
A 1 526 THR 526 526 526 THR THR A . n 
A 1 527 PRO 527 527 527 PRO PRO A . n 
A 1 528 VAL 528 528 528 VAL VAL A . n 
A 1 529 TYR 529 529 529 TYR TYR A . n 
A 1 530 ALA 530 530 530 ALA ALA A . n 
A 1 531 GLU 531 531 531 GLU GLU A . n 
A 1 532 VAL 532 532 532 VAL VAL A . n 
A 1 533 LYS 533 533 533 LYS LYS A . n 
A 1 534 ARG 534 534 534 ARG ARG A . n 
A 1 535 VAL 535 535 535 VAL VAL A . n 
A 1 536 GLY 536 536 536 GLY GLY A . n 
A 1 537 ASP 537 537 537 ASP ASP A . n 
A 1 538 THR 538 538 538 THR THR A . n 
A 1 539 VAL 539 539 539 VAL VAL A . n 
A 1 540 LEU 540 540 540 LEU LEU A . n 
A 1 541 GLY 541 541 541 GLY GLY A . n 
A 1 542 MET 542 542 542 MET MET A . n 
A 1 543 ALA 543 543 543 ALA ALA A . n 
A 1 544 THR 544 544 544 THR THR A . n 
A 1 545 GLN 545 545 545 GLN GLN A . n 
A 1 546 CYS 546 546 546 CYS CYS A . n 
A 1 547 VAL 547 547 547 VAL VAL A . n 
A 1 548 GLN 548 548 548 GLN GLN A . n 
A 1 549 MET 549 549 549 MET MET A . n 
A 1 550 LYS 550 550 550 LYS LYS A . n 
A 1 551 ASN 551 551 551 ASN ASN A . n 
A 1 552 VAL 552 552 552 VAL VAL A . n 
A 1 553 GLN 553 553 553 GLN GLN A . n 
A 1 554 ARG 554 554 554 ARG ARG A . n 
A 1 555 THR 555 555 555 THR THR A . n 
A 1 556 THR 556 556 556 THR THR A . n 
A 1 557 PRO 557 557 557 PRO PRO A . n 
A 1 558 GLN 558 558 558 GLN GLN A . n 
A 1 559 THR 559 559 559 THR THR A . n 
A 1 560 LEU 560 560 560 LEU LEU A . n 
A 1 561 SER 561 561 561 SER SER A . n 
A 1 562 ASN 562 562 562 ASN ASN A . n 
A 1 563 LEU 563 563 563 LEU LEU A . n 
A 1 564 CYS 564 564 564 CYS CYS A . n 
A 1 565 LEU 565 565 565 LEU LEU A . n 
A 1 566 LYS 566 566 566 LYS LYS A . n 
A 1 567 ILE 567 567 567 ILE ILE A . n 
A 1 568 ASN 568 568 568 ASN ASN A . n 
A 1 569 VAL 569 569 569 VAL VAL A . n 
A 1 570 LYS 570 570 570 LYS LYS A . n 
A 1 571 LEU 571 571 571 LEU LEU A . n 
A 1 572 GLY 572 572 572 GLY GLY A . n 
A 1 573 GLY 573 573 573 GLY GLY A . n 
A 1 574 VAL 574 574 574 VAL VAL A . n 
A 1 575 ASN 575 575 575 ASN ASN A . n 
A 1 576 ASN 576 576 576 ASN ASN A . n 
A 1 577 ILE 577 577 577 ILE ILE A . n 
A 1 578 LEU 578 578 578 LEU LEU A . n 
A 1 579 LEU 579 579 579 LEU LEU A . n 
A 1 580 PRO 580 580 580 PRO PRO A . n 
A 1 581 GLN 581 581 581 GLN GLN A . n 
A 1 582 GLY 582 582 582 GLY GLY A . n 
A 1 583 ARG 583 583 583 ARG ARG A . n 
A 1 584 PRO 584 584 584 PRO PRO A . n 
A 1 585 PRO 585 585 585 PRO PRO A . n 
A 1 586 VAL 586 586 586 VAL VAL A . n 
A 1 587 PHE 587 587 587 PHE PHE A . n 
A 1 588 GLN 588 588 588 GLN GLN A . n 
A 1 589 GLN 589 589 589 GLN GLN A . n 
A 1 590 PRO 590 590 590 PRO PRO A . n 
A 1 591 VAL 591 591 591 VAL VAL A . n 
A 1 592 ILE 592 592 592 ILE ILE A . n 
A 1 593 PHE 593 593 593 PHE PHE A . n 
A 1 594 LEU 594 594 594 LEU LEU A . n 
A 1 595 GLY 595 595 595 GLY GLY A . n 
A 1 596 ALA 596 596 596 ALA ALA A . n 
A 1 597 ASP 597 597 597 ASP ASP A . n 
A 1 598 VAL 598 598 598 VAL VAL A . n 
A 1 599 THR 599 599 599 THR THR A . n 
A 1 600 HIS 600 600 ?   ?   ?   A . n 
A 1 601 PRO 601 601 ?   ?   ?   A . n 
A 1 602 PRO 602 602 ?   ?   ?   A . n 
A 1 603 ALA 603 603 ?   ?   ?   A . n 
A 1 604 GLY 604 604 ?   ?   ?   A . n 
A 1 605 ASP 605 605 ?   ?   ?   A . n 
A 1 606 GLY 606 606 ?   ?   ?   A . n 
A 1 607 LYS 607 607 ?   ?   ?   A . n 
A 1 608 LYS 608 608 608 LYS LYS A . n 
A 1 609 PRO 609 609 609 PRO PRO A . n 
A 1 610 SER 610 610 610 SER SER A . n 
A 1 611 ILE 611 611 611 ILE ILE A . n 
A 1 612 ALA 612 612 612 ALA ALA A . n 
A 1 613 ALA 613 613 613 ALA ALA A . n 
A 1 614 VAL 614 614 614 VAL VAL A . n 
A 1 615 VAL 615 615 615 VAL VAL A . n 
A 1 616 GLY 616 616 616 GLY GLY A . n 
A 1 617 SER 617 617 617 SER SER A . n 
A 1 618 MET 618 618 618 MET MET A . n 
A 1 619 ASP 619 619 619 ASP ASP A . n 
A 1 620 ALA 620 620 620 ALA ALA A . n 
A 1 621 HIS 621 621 621 HIS HIS A . n 
A 1 622 PRO 622 622 622 PRO PRO A . n 
A 1 623 ASN 623 623 623 ASN ASN A . n 
A 1 624 ARG 624 624 624 ARG ARG A . n 
A 1 625 TYR 625 625 625 TYR TYR A . n 
A 1 626 CYS 626 626 626 CYS CYS A . n 
A 1 627 ALA 627 627 627 ALA ALA A . n 
A 1 628 THR 628 628 628 THR THR A . n 
A 1 629 VAL 629 629 629 VAL VAL A . n 
A 1 630 ARG 630 630 630 ARG ARG A . n 
A 1 631 VAL 631 631 631 VAL VAL A . n 
A 1 632 GLN 632 632 632 GLN GLN A . n 
A 1 633 GLN 633 633 633 GLN GLN A . n 
A 1 634 HIS 634 634 634 HIS HIS A . n 
A 1 635 ARG 635 635 635 ARG ARG A . n 
A 1 636 GLN 636 636 636 GLN GLN A . n 
A 1 637 GLU 637 637 637 GLU GLU A . n 
A 1 638 ILE 638 638 638 ILE ILE A . n 
A 1 639 ILE 639 639 639 ILE ILE A . n 
A 1 640 GLN 640 640 640 GLN GLN A . n 
A 1 641 ASP 641 641 641 ASP ASP A . n 
A 1 642 LEU 642 642 642 LEU LEU A . n 
A 1 643 ALA 643 643 643 ALA ALA A . n 
A 1 644 ALA 644 644 644 ALA ALA A . n 
A 1 645 MET 645 645 645 MET MET A . n 
A 1 646 VAL 646 646 646 VAL VAL A . n 
A 1 647 ARG 647 647 647 ARG ARG A . n 
A 1 648 GLU 648 648 648 GLU GLU A . n 
A 1 649 LEU 649 649 649 LEU LEU A . n 
A 1 650 LEU 650 650 650 LEU LEU A . n 
A 1 651 ILE 651 651 651 ILE ILE A . n 
A 1 652 GLN 652 652 652 GLN GLN A . n 
A 1 653 PHE 653 653 653 PHE PHE A . n 
A 1 654 TYR 654 654 654 TYR TYR A . n 
A 1 655 LYS 655 655 655 LYS LYS A . n 
A 1 656 SER 656 656 656 SER SER A . n 
A 1 657 THR 657 657 657 THR THR A . n 
A 1 658 ARG 658 658 658 ARG ARG A . n 
A 1 659 PHE 659 659 659 PHE PHE A . n 
A 1 660 LYS 660 660 660 LYS LYS A . n 
A 1 661 PRO 661 661 661 PRO PRO A . n 
A 1 662 THR 662 662 662 THR THR A . n 
A 1 663 ARG 663 663 663 ARG ARG A . n 
A 1 664 ILE 664 664 664 ILE ILE A . n 
A 1 665 ILE 665 665 665 ILE ILE A . n 
A 1 666 PHE 666 666 666 PHE PHE A . n 
A 1 667 TYR 667 667 667 TYR TYR A . n 
A 1 668 ARG 668 668 668 ARG ARG A . n 
A 1 669 ALA 669 669 669 ALA ALA A . n 
A 1 670 GLY 670 670 670 GLY GLY A . n 
A 1 671 VAL 671 671 671 VAL VAL A . n 
A 1 672 SER 672 672 672 SER SER A . n 
A 1 673 GLU 673 673 673 GLU GLU A . n 
A 1 674 GLY 674 674 674 GLY GLY A . n 
A 1 675 GLN 675 675 675 GLN GLN A . n 
A 1 676 PHE 676 676 676 PHE PHE A . n 
A 1 677 GLN 677 677 677 GLN GLN A . n 
A 1 678 GLN 678 678 678 GLN GLN A . n 
A 1 679 VAL 679 679 679 VAL VAL A . n 
A 1 680 LEU 680 680 680 LEU LEU A . n 
A 1 681 HIS 681 681 681 HIS HIS A . n 
A 1 682 HIS 682 682 682 HIS HIS A . n 
A 1 683 GLU 683 683 683 GLU GLU A . n 
A 1 684 LEU 684 684 684 LEU LEU A . n 
A 1 685 LEU 685 685 685 LEU LEU A . n 
A 1 686 ALA 686 686 686 ALA ALA A . n 
A 1 687 ILE 687 687 687 ILE ILE A . n 
A 1 688 ARG 688 688 688 ARG ARG A . n 
A 1 689 GLU 689 689 689 GLU GLU A . n 
A 1 690 ALA 690 690 690 ALA ALA A . n 
A 1 691 CYS 691 691 691 CYS CYS A . n 
A 1 692 ILE 692 692 692 ILE ILE A . n 
A 1 693 LYS 693 693 693 LYS LYS A . n 
A 1 694 LEU 694 694 694 LEU LEU A . n 
A 1 695 GLU 695 695 695 GLU GLU A . n 
A 1 696 LYS 696 696 696 LYS LYS A . n 
A 1 697 ASP 697 697 697 ASP ASP A . n 
A 1 698 TYR 698 698 698 TYR TYR A . n 
A 1 699 GLN 699 699 699 GLN GLN A . n 
A 1 700 PRO 700 700 700 PRO PRO A . n 
A 1 701 GLY 701 701 701 GLY GLY A . n 
A 1 702 ILE 702 702 702 ILE ILE A . n 
A 1 703 THR 703 703 703 THR THR A . n 
A 1 704 PHE 704 704 704 PHE PHE A . n 
A 1 705 ILE 705 705 705 ILE ILE A . n 
A 1 706 VAL 706 706 706 VAL VAL A . n 
A 1 707 VAL 707 707 707 VAL VAL A . n 
A 1 708 GLN 708 708 708 GLN GLN A . n 
A 1 709 LYS 709 709 709 LYS LYS A . n 
A 1 710 ARG 710 710 710 ARG ARG A . n 
A 1 711 HIS 711 711 711 HIS HIS A . n 
A 1 712 HIS 712 712 712 HIS HIS A . n 
A 1 713 THR 713 713 713 THR THR A . n 
A 1 714 ARG 714 714 714 ARG ARG A . n 
A 1 715 LEU 715 715 715 LEU LEU A . n 
A 1 716 PHE 716 716 716 PHE PHE A . n 
A 1 717 CYS 717 717 717 CYS CYS A . n 
A 1 718 THR 718 718 718 THR THR A . n 
A 1 719 ASP 719 719 719 ASP ASP A . n 
A 1 720 LYS 720 720 720 LYS LYS A . n 
A 1 721 ASN 721 721 721 ASN ASN A . n 
A 1 722 GLU 722 722 722 GLU GLU A . n 
A 1 723 ARG 723 723 723 ARG ARG A . n 
A 1 724 VAL 724 724 724 VAL VAL A . n 
A 1 725 GLY 725 725 725 GLY GLY A . n 
A 1 726 LYS 726 726 726 LYS LYS A . n 
A 1 727 SER 727 727 727 SER SER A . n 
A 1 728 GLY 728 728 728 GLY GLY A . n 
A 1 729 ASN 729 729 729 ASN ASN A . n 
A 1 730 ILE 730 730 730 ILE ILE A . n 
A 1 731 PRO 731 731 731 PRO PRO A . n 
A 1 732 ALA 732 732 732 ALA ALA A . n 
A 1 733 GLY 733 733 733 GLY GLY A . n 
A 1 734 THR 734 734 734 THR THR A . n 
A 1 735 THR 735 735 735 THR THR A . n 
A 1 736 VAL 736 736 736 VAL VAL A . n 
A 1 737 ASP 737 737 737 ASP ASP A . n 
A 1 738 THR 738 738 738 THR THR A . n 
A 1 739 LYS 739 739 739 LYS LYS A . n 
A 1 740 ILE 740 740 740 ILE ILE A . n 
A 1 741 THR 741 741 741 THR THR A . n 
A 1 742 HIS 742 742 742 HIS HIS A . n 
A 1 743 PRO 743 743 743 PRO PRO A . n 
A 1 744 THR 744 744 744 THR THR A . n 
A 1 745 GLU 745 745 745 GLU GLU A . n 
A 1 746 PHE 746 746 746 PHE PHE A . n 
A 1 747 ASP 747 747 747 ASP ASP A . n 
A 1 748 PHE 748 748 748 PHE PHE A . n 
A 1 749 TYR 749 749 749 TYR TYR A . n 
A 1 750 LEU 750 750 750 LEU LEU A . n 
A 1 751 CYS 751 751 751 CYS CYS A . n 
A 1 752 SER 752 752 752 SER SER A . n 
A 1 753 HIS 753 753 753 HIS HIS A . n 
A 1 754 ALA 754 754 754 ALA ALA A . n 
A 1 755 GLY 755 755 755 GLY GLY A . n 
A 1 756 ILE 756 756 756 ILE ILE A . n 
A 1 757 GLN 757 757 757 GLN GLN A . n 
A 1 758 GLY 758 758 758 GLY GLY A . n 
A 1 759 THR 759 759 759 THR THR A . n 
A 1 760 SER 760 760 760 SER SER A . n 
A 1 761 ARG 761 761 761 ARG ARG A . n 
A 1 762 PRO 762 762 762 PRO PRO A . n 
A 1 763 SER 763 763 763 SER SER A . n 
A 1 764 HIS 764 764 764 HIS HIS A . n 
A 1 765 TYR 765 765 765 TYR TYR A . n 
A 1 766 HIS 766 766 766 HIS HIS A . n 
A 1 767 VAL 767 767 767 VAL VAL A . n 
A 1 768 LEU 768 768 768 LEU LEU A . n 
A 1 769 TRP 769 769 769 TRP TRP A . n 
A 1 770 ASP 770 770 770 ASP ASP A . n 
A 1 771 ASP 771 771 771 ASP ASP A . n 
A 1 772 ASN 772 772 772 ASN ASN A . n 
A 1 773 ARG 773 773 773 ARG ARG A . n 
A 1 774 PHE 774 774 774 PHE PHE A . n 
A 1 775 SER 775 775 775 SER SER A . n 
A 1 776 SER 776 776 776 SER SER A . n 
A 1 777 ASP 777 777 777 ASP ASP A . n 
A 1 778 GLU 778 778 778 GLU GLU A . n 
A 1 779 LEU 779 779 779 LEU LEU A . n 
A 1 780 GLN 780 780 780 GLN GLN A . n 
A 1 781 ILE 781 781 781 ILE ILE A . n 
A 1 782 LEU 782 782 782 LEU LEU A . n 
A 1 783 THR 783 783 783 THR THR A . n 
A 1 784 TYR 784 784 784 TYR TYR A . n 
A 1 785 GLN 785 785 785 GLN GLN A . n 
A 1 786 LEU 786 786 786 LEU LEU A . n 
A 1 787 CYS 787 787 787 CYS CYS A . n 
A 1 788 HIS 788 788 788 HIS HIS A . n 
A 1 789 THR 789 789 789 THR THR A . n 
A 1 790 TYR 790 790 790 TYR TYR A . n 
A 1 791 VAL 791 791 791 VAL VAL A . n 
A 1 792 ARG 792 792 792 ARG ARG A . n 
A 1 793 CYS 793 793 793 CYS CYS A . n 
A 1 794 THR 794 794 794 THR THR A . n 
A 1 795 ARG 795 795 795 ARG ARG A . n 
A 1 796 SER 796 796 796 SER SER A . n 
A 1 797 VAL 797 797 797 VAL VAL A . n 
A 1 798 SER 798 798 798 SER SER A . n 
A 1 799 ILE 799 799 799 ILE ILE A . n 
A 1 800 PRO 800 800 800 PRO PRO A . n 
A 1 801 ALA 801 801 801 ALA ALA A . n 
A 1 802 PRO 802 802 802 PRO PRO A . n 
A 1 803 ALA 803 803 803 ALA ALA A . n 
A 1 804 TYR 804 804 804 TYR TYR A . n 
A 1 805 TYR 805 805 805 TYR TYR A . n 
A 1 806 ALA 806 806 806 ALA ALA A . n 
A 1 807 HIS 807 807 807 HIS HIS A . n 
A 1 808 LEU 808 808 808 LEU LEU A . n 
A 1 809 VAL 809 809 809 VAL VAL A . n 
A 1 810 ALA 810 810 810 ALA ALA A . n 
A 1 811 PHE 811 811 811 PHE PHE A . n 
A 1 812 ARG 812 812 812 ARG ARG A . n 
A 1 813 ALA 813 813 813 ALA ALA A . n 
A 1 814 ARG 814 814 814 ARG ARG A . n 
A 1 815 TYR 815 815 815 TYR TYR A . n 
A 1 816 HIS 816 816 816 HIS HIS A . n 
A 1 817 LEU 817 817 817 LEU LEU A . n 
A 1 818 VAL 818 818 818 VAL VAL A . n 
A 1 819 ASP 819 819 819 ASP ASP A . n 
A 1 820 LYS 820 820 820 LYS LYS A . n 
A 1 821 GLU 821 821 ?   ?   ?   A . n 
A 1 822 HIS 822 822 ?   ?   ?   A . n 
A 1 823 ASP 823 823 ?   ?   ?   A . n 
A 1 824 SER 824 824 ?   ?   ?   A . n 
A 1 825 ALA 825 825 ?   ?   ?   A . n 
A 1 826 GLU 826 826 ?   ?   ?   A . n 
A 1 827 GLY 827 827 ?   ?   ?   A . n 
A 1 828 SER 828 828 ?   ?   ?   A . n 
A 1 829 HIS 829 829 ?   ?   ?   A . n 
A 1 830 THR 830 830 ?   ?   ?   A . n 
A 1 831 SER 831 831 ?   ?   ?   A . n 
A 1 832 GLY 832 832 ?   ?   ?   A . n 
A 1 833 GLN 833 833 ?   ?   ?   A . n 
A 1 834 SER 834 834 ?   ?   ?   A . n 
A 1 835 ASN 835 835 ?   ?   ?   A . n 
A 1 836 GLY 836 836 ?   ?   ?   A . n 
A 1 837 ARG 837 837 ?   ?   ?   A . n 
A 1 838 ASP 838 838 838 ASP ASP A . n 
A 1 839 HIS 839 839 839 HIS HIS A . n 
A 1 840 GLN 840 840 840 GLN GLN A . n 
A 1 841 ALA 841 841 841 ALA ALA A . n 
A 1 842 LEU 842 842 842 LEU LEU A . n 
A 1 843 ALA 843 843 843 ALA ALA A . n 
A 1 844 LYS 844 844 844 LYS LYS A . n 
A 1 845 ALA 845 845 845 ALA ALA A . n 
A 1 846 VAL 846 846 846 VAL VAL A . n 
A 1 847 GLN 847 847 847 GLN GLN A . n 
A 1 848 VAL 848 848 848 VAL VAL A . n 
A 1 849 HIS 849 849 849 HIS HIS A . n 
A 1 850 GLN 850 850 850 GLN GLN A . n 
A 1 851 ASP 851 851 851 ASP ASP A . n 
A 1 852 THR 852 852 852 THR THR A . n 
A 1 853 LEU 853 853 853 LEU LEU A . n 
A 1 854 ARG 854 854 854 ARG ARG A . n 
A 1 855 THR 855 855 855 THR THR A . n 
A 1 856 MET 856 856 856 MET MET A . n 
A 1 857 TYR 857 857 857 TYR TYR A . n 
A 1 858 PHE 858 858 858 PHE PHE A . n 
A 1 859 ALA 859 859 859 ALA ALA A . n 
B 2 1   U   1   1   1   U   U   B . n 
B 2 2   A   2   2   2   A   A   B . n 
B 2 3   C   3   3   3   C   C   B . n 
B 2 4   A   4   4   4   A   A   B . n 
B 2 5   A   5   5   5   A   A   B . n 
B 2 6   G   6   6   6   G   G   B . n 
B 2 7   A   7   7   7   A   A   B . n 
B 2 8   G   8   8   8   G   G   B . n 
B 2 9   C   9   9   9   C   C   B . n 
B 2 10  C   10  10  10  C   C   B . n 
C 3 1   G   1   10  10  G   G   C . n 
C 3 2   G   2   11  11  G   G   C . n 
C 3 3   C   3   12  12  C   C   C . n 
C 3 4   U   4   13  13  U   U   C . n 
C 3 5   C   5   14  14  C   C   C . n 
C 3 6   U   6   15  15  U   U   C . n 
C 3 7   U   7   16  16  U   U   C . n 
C 3 8   G   8   17  17  G   G   C . n 
C 3 9   U   9   18  18  U   U   C . n 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9K6P 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_struct.entry_id                     9K6P 
_struct.title                        'Cryo-EM Structure of hAGO2D669A-siRNA-target (12-nt)' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9K6P 
_struct_keywords.text            'Argonaute protein, siRNA, RNA BINDING PROTEIN/RNA, RNA BINDING PROTEIN' 
_struct_keywords.pdbx_keywords   'RNA BINDING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP AGO2_HUMAN Q9UKV8 ? 1 
;MYSGAGPALAPPAPPPPIQGYAFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELDIKPEKCPRRVNREIVEHMVQ
HFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKVELEVTLPGEGKDRIFKVSIKWVSCVSLQALHDALSGRLPSVPFETIQ
ALDVVMRHLPSMRYTPVGRSFFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDF
KSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQESGQTVECTVAQYFKDRHKLVL
RYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATARSAPDRQEEISKLMRSASFNTDPYVREFGIM
VKDEMTDVTGRVLQPPSILYGGRNKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRD
AGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQRTTPQTL
SNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQ
DLAAMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCTDK
NERVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQILTYQLCHTYVRCTRSVSIP
APAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDHQALAKAVQVHQDTLRTMYFA
;
1 
2 PDB 9K6P       9K6P   ? 2 ? 1 
3 PDB 9K6P       9K6P   ? 3 ? 1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9K6P A 1 ? 859 ? Q9UKV8 1  ? 859 ? 1  859 
2 2 9K6P B 1 ? 10  ? 9K6P   1  ? 10  ? 1  10  
3 3 9K6P C 1 ? 9   ? 9K6P   10 ? 18  ? 10 18  
# 
_struct_ref_seq_dif.align_id                     1 
_struct_ref_seq_dif.pdbx_pdb_id_code             9K6P 
_struct_ref_seq_dif.mon_id                       ALA 
_struct_ref_seq_dif.pdbx_pdb_strand_id           A 
_struct_ref_seq_dif.seq_num                      669 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   Q9UKV8 
_struct_ref_seq_dif.db_mon_id                    ASP 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          669 
_struct_ref_seq_dif.details                      'engineered mutation' 
_struct_ref_seq_dif.pdbx_auth_seq_num            669 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 PRO A 67  ? PHE A 82  ? PRO A 67  PHE A 82  1 ? 16 
HELX_P HELX_P2  AA2 PHE A 82  ? PHE A 87  ? PHE A 82  PHE A 87  1 ? 6  
HELX_P HELX_P3  AA3 LEU A 140 ? SER A 148 ? LEU A 140 SER A 148 1 ? 9  
HELX_P HELX_P4  AA4 PHE A 156 ? MET A 166 ? PHE A 156 MET A 166 1 ? 11 
HELX_P HELX_P5  AA5 ARG A 167 ? TYR A 174 ? ARG A 167 TYR A 174 1 ? 8  
HELX_P HELX_P6  AA6 PRO A 229 ? VAL A 237 ? PRO A 229 VAL A 237 1 ? 9  
HELX_P HELX_P7  AA7 THR A 251 ? ILE A 262 ? THR A 251 ILE A 262 1 ? 12 
HELX_P HELX_P8  AA8 THR A 357 ? ALA A 369 ? THR A 357 ALA A 369 1 ? 13 
HELX_P HELX_P9  AA9 SER A 371 ? ALA A 386 ? SER A 371 ALA A 386 1 ? 16 
HELX_P HELX_P10 AB1 ASP A 391 ? PHE A 397 ? ASP A 391 PHE A 397 1 ? 7  
HELX_P HELX_P11 AB2 THR A 463 ? ALA A 481 ? THR A 463 ALA A 481 1 ? 19 
HELX_P HELX_P12 AB3 VAL A 501 ? TYR A 512 ? VAL A 501 TYR A 512 1 ? 12 
HELX_P HELX_P13 AB4 THR A 526 ? VAL A 539 ? THR A 526 VAL A 539 1 ? 14 
HELX_P HELX_P14 AB5 THR A 556 ? GLY A 572 ? THR A 556 GLY A 572 1 ? 17 
HELX_P HELX_P15 AB6 ASP A 641 ? ARG A 658 ? ASP A 641 ARG A 658 1 ? 18 
HELX_P HELX_P16 AB7 SER A 672 ? GLY A 674 ? SER A 672 GLY A 674 5 ? 3  
HELX_P HELX_P17 AB8 GLN A 675 ? GLU A 695 ? GLN A 675 GLU A 695 1 ? 21 
HELX_P HELX_P18 AB9 CYS A 717 ? ASN A 721 ? CYS A 717 ASN A 721 5 ? 5  
HELX_P HELX_P19 AC1 SER A 775 ? HIS A 788 ? SER A 775 HIS A 788 1 ? 14 
HELX_P HELX_P20 AC2 PRO A 800 ? HIS A 816 ? PRO A 800 HIS A 816 1 ? 17 
HELX_P HELX_P21 AC3 HIS A 839 ? LYS A 844 ? HIS A 839 LYS A 844 1 ? 6  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1  disulf ? ? A CYS 455 SG ? ? ? 1_555 A CYS 462 SG ? ? A CYS 455 A CYS 462 1_555 ? ? ? ? ? ? ?            2.026 ? ? 
hydrog1  hydrog ? ? B A   2   N6 ? ? ? 1_555 C U   9   O4 ? ? B A   2   C U   18  1_555 ? ? ? ? ? ? 'A-U PAIR'   ?     ? ? 
hydrog2  hydrog ? ? B C   3   N3 ? ? ? 1_555 C G   8   N1 ? ? B C   3   C G   17  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog3  hydrog ? ? B C   3   N4 ? ? ? 1_555 C G   8   O6 ? ? B C   3   C G   17  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog4  hydrog ? ? B C   3   O2 ? ? ? 1_555 C G   8   N2 ? ? B C   3   C G   17  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog5  hydrog ? ? B A   4   N1 ? ? ? 1_555 C U   7   N3 ? ? B A   4   C U   16  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog6  hydrog ? ? B A   4   N6 ? ? ? 1_555 C U   7   O4 ? ? B A   4   C U   16  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog7  hydrog ? ? B A   5   N1 ? ? ? 1_555 C U   6   N3 ? ? B A   5   C U   15  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog8  hydrog ? ? B A   5   N6 ? ? ? 1_555 C U   6   O4 ? ? B A   5   C U   15  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog9  hydrog ? ? B G   6   N1 ? ? ? 1_555 C C   5   N3 ? ? B G   6   C C   14  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog10 hydrog ? ? B G   6   N2 ? ? ? 1_555 C C   5   O2 ? ? B G   6   C C   14  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog11 hydrog ? ? B G   6   O6 ? ? ? 1_555 C C   5   N4 ? ? B G   6   C C   14  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog12 hydrog ? ? B A   7   N1 ? ? ? 1_555 C U   4   N3 ? ? B A   7   C U   13  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog13 hydrog ? ? B A   7   N6 ? ? ? 1_555 C U   4   O4 ? ? B A   7   C U   13  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog14 hydrog ? ? B G   8   N1 ? ? ? 1_555 C C   3   N3 ? ? B G   8   C C   12  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog15 hydrog ? ? B G   8   N2 ? ? ? 1_555 C C   3   O2 ? ? B G   8   C C   12  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog16 hydrog ? ? B G   8   O6 ? ? ? 1_555 C C   3   N4 ? ? B G   8   C C   12  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
hydrog ? ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      CYS 
_pdbx_modification_feature.label_asym_id                      A 
_pdbx_modification_feature.label_seq_id                       455 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      462 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       CYS 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        455 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       462 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               SG 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                . 
_pdbx_modification_feature.ref_pcm_id                         . 
_pdbx_modification_feature.ref_comp_id                        . 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Disulfide bridge' 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          LYS 
_struct_mon_prot_cis.label_seq_id           62 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           LYS 
_struct_mon_prot_cis.auth_seq_id            62 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    63 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     63 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       -1.51 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 3 ? 
AA2 ? 2 ? 
AA3 ? 5 ? 
AA4 ? 2 ? 
AA5 ? 2 ? 
AA6 ? 2 ? 
AA7 ? 3 ? 
AA8 ? 4 ? 
AA9 ? 7 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA3 4 5 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA7 2 3 ? anti-parallel 
AA8 1 2 ? parallel      
AA8 2 3 ? parallel      
AA8 3 4 ? parallel      
AA9 1 2 ? anti-parallel 
AA9 2 3 ? anti-parallel 
AA9 3 4 ? parallel      
AA9 4 5 ? parallel      
AA9 5 6 ? anti-parallel 
AA9 6 7 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 408 ? VAL A 412 ? VAL A 408 VAL A 412 
AA1 2 ARG A 36  ? ALA A 42  ? ARG A 36  ALA A 42  
AA1 3 LEU A 715 ? PHE A 716 ? LEU A 715 PHE A 716 
AA2 1 PHE A 45  ? ASP A 48  ? PHE A 45  ASP A 48  
AA2 2 MET A 400 ? MET A 405 ? MET A 400 MET A 405 
AA3 1 VAL A 93  ? PHE A 94  ? VAL A 93  PHE A 94  
AA3 2 ASN A 99  ? THR A 102 ? ASN A 99  THR A 102 
AA3 3 ILE A 54  ? LYS A 62  ? ILE A 54  LYS A 62  
AA3 4 ARG A 126 ? VAL A 138 ? ARG A 126 VAL A 138 
AA3 5 VAL A 113 ? LEU A 119 ? VAL A 113 LEU A 119 
AA4 1 GLU A 197 ? TRP A 199 ? GLU A 197 TRP A 199 
AA4 2 THR A 222 ? PHE A 224 ? THR A 222 PHE A 224 
AA5 1 PHE A 202 ? VAL A 206 ? PHE A 202 VAL A 206 
AA5 2 LEU A 215 ? VAL A 219 ? LEU A 215 VAL A 219 
AA6 1 VAL A 267 ? GLU A 268 ? VAL A 267 GLU A 268 
AA6 2 ASN A 345 ? ILE A 346 ? ASN A 345 ILE A 346 
AA7 1 ILE A 427 ? ALA A 428 ? ILE A 427 ALA A 428 
AA7 2 ILE A 418 ? LEU A 419 ? ILE A 418 LEU A 419 
AA7 3 ILE A 577 ? LEU A 578 ? ILE A 577 LEU A 578 
AA8 1 PHE A 491 ? TYR A 494 ? PHE A 491 TYR A 494 
AA8 2 ALA A 452 ? CYS A 455 ? ALA A 452 CYS A 455 
AA8 3 VAL A 518 ? LEU A 522 ? VAL A 518 LEU A 522 
AA8 4 THR A 544 ? GLN A 548 ? THR A 544 GLN A 548 
AA9 1 TYR A 625 ? GLN A 632 ? TYR A 625 GLN A 632 
AA9 2 SER A 610 ? SER A 617 ? SER A 610 SER A 617 
AA9 3 VAL A 591 ? VAL A 598 ? VAL A 591 VAL A 598 
AA9 4 ARG A 663 ? ARG A 668 ? ARG A 663 ARG A 668 
AA9 5 GLY A 701 ? VAL A 707 ? GLY A 701 VAL A 707 
AA9 6 SER A 763 ? ASP A 770 ? SER A 763 ASP A 770 
AA9 7 TYR A 749 ? LEU A 750 ? TYR A 749 LEU A 750 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O GLY A 410 ? O GLY A 410 N ILE A 38  ? N ILE A 38  
AA1 2 3 N GLN A 41  ? N GLN A 41  O PHE A 716 ? O PHE A 716 
AA2 1 2 N GLU A 46  ? N GLU A 46  O LYS A 402 ? O LYS A 402 
AA3 1 2 N VAL A 93  ? N VAL A 93  O TYR A 101 ? O TYR A 101 
AA3 2 3 O THR A 102 ? O THR A 102 N TYR A 55  ? N TYR A 55  
AA3 3 4 N LYS A 62  ? N LYS A 62  O LYS A 129 ? O LYS A 129 
AA3 4 5 O PHE A 128 ? O PHE A 128 N VAL A 117 ? N VAL A 117 
AA4 1 2 N GLU A 197 ? N GLU A 197 O PHE A 224 ? O PHE A 224 
AA5 1 2 N SER A 205 ? N SER A 205 O ASN A 216 ? O ASN A 216 
AA6 1 2 N GLU A 268 ? N GLU A 268 O ASN A 345 ? O ASN A 345 
AA7 1 2 O ALA A 428 ? O ALA A 428 N ILE A 418 ? N ILE A 418 
AA7 2 3 N LEU A 419 ? N LEU A 419 O ILE A 577 ? O ILE A 577 
AA8 1 2 O PHE A 491 ? O PHE A 491 N ILE A 453 ? N ILE A 453 
AA8 2 3 N ALA A 454 ? N ALA A 454 O VAL A 519 ? O VAL A 519 
AA8 3 4 N VAL A 520 ? N VAL A 520 O GLN A 545 ? O GLN A 545 
AA9 1 2 O ARG A 630 ? O ARG A 630 N ALA A 612 ? N ALA A 612 
AA9 2 3 O VAL A 615 ? O VAL A 615 N GLY A 595 ? N GLY A 595 
AA9 3 4 N ALA A 596 ? N ALA A 596 O TYR A 667 ? O TYR A 667 
AA9 4 5 N ILE A 664 ? N ILE A 664 O GLY A 701 ? O GLY A 701 
AA9 5 6 N PHE A 704 ? N PHE A 704 O TRP A 769 ? O TRP A 769 
AA9 6 7 O SER A 763 ? O SER A 763 N LEU A 750 ? N LEU A 750 
# 
_pdbx_entry_details.entry_id                   9K6P 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_rmsd_bond.id 
_pdbx_validate_rmsd_bond.PDB_model_num 
_pdbx_validate_rmsd_bond.auth_atom_id_1 
_pdbx_validate_rmsd_bond.auth_asym_id_1 
_pdbx_validate_rmsd_bond.auth_comp_id_1 
_pdbx_validate_rmsd_bond.auth_seq_id_1 
_pdbx_validate_rmsd_bond.PDB_ins_code_1 
_pdbx_validate_rmsd_bond.label_alt_id_1 
_pdbx_validate_rmsd_bond.auth_atom_id_2 
_pdbx_validate_rmsd_bond.auth_asym_id_2 
_pdbx_validate_rmsd_bond.auth_comp_id_2 
_pdbx_validate_rmsd_bond.auth_seq_id_2 
_pdbx_validate_rmsd_bond.PDB_ins_code_2 
_pdbx_validate_rmsd_bond.label_alt_id_2 
_pdbx_validate_rmsd_bond.bond_value 
_pdbx_validate_rmsd_bond.bond_target_value 
_pdbx_validate_rmsd_bond.bond_deviation 
_pdbx_validate_rmsd_bond.bond_standard_deviation 
_pdbx_validate_rmsd_bond.linker_flag 
1 1 CG A PRO 92  ? ? CD  A PRO 92  ? ? 1.303 1.502 -0.199 0.033 N 
2 1 CB A PRO 527 ? ? CG  A PRO 527 ? ? 1.189 1.495 -0.306 0.050 N 
3 1 CG A PRO 527 ? ? CD  A PRO 527 ? ? 1.138 1.502 -0.364 0.033 N 
4 1 P  B U   1   ? ? OP3 B U   1   ? ? 1.474 1.607 -0.133 0.012 N 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1  1 CA    A PRO 92  ? ? N     A PRO 92  ? ? CD  A PRO 92  ? ? 102.74 111.70 -8.96  1.40 N 
2  1 CA    A PRO 92  ? ? CB    A PRO 92  ? ? CG  A PRO 92  ? ? 93.19  104.80 -11.61 1.90 N 
3  1 N     A PRO 92  ? ? CD    A PRO 92  ? ? CG  A PRO 92  ? ? 89.20  103.20 -14.00 1.50 N 
4  1 CA    A LEU 143 ? ? CB    A LEU 143 ? ? CG  A LEU 143 ? ? 130.20 115.30 14.90  2.30 N 
5  1 CA    A MET 166 ? ? CB    A MET 166 ? ? CG  A MET 166 ? ? 127.73 113.30 14.43  1.70 N 
6  1 CA    A CYS 352 ? ? CB    A CYS 352 ? ? SG  A CYS 352 ? ? 123.12 114.20 8.92   1.10 N 
7  1 CB    A ASP 374 ? ? CG    A ASP 374 ? ? OD1 A ASP 374 ? ? 125.89 118.30 7.59   0.90 N 
8  1 CB    A ASP 403 ? ? CG    A ASP 403 ? ? OD1 A ASP 403 ? ? 126.13 118.30 7.83   0.90 N 
9  1 CG1   A VAL 431 ? ? CB    A VAL 431 ? ? CG2 A VAL 431 ? ? 100.07 110.90 -10.83 1.60 N 
10 1 CA    A PRO 527 ? ? N     A PRO 527 ? ? CD  A PRO 527 ? ? 92.39  111.70 -19.31 1.40 N 
11 1 CA    A PRO 527 ? ? CB    A PRO 527 ? ? CG  A PRO 527 ? ? 78.31  104.80 -26.49 1.90 N 
12 1 CB    A PRO 527 ? ? CG    A PRO 527 ? ? CD  A PRO 527 ? ? 145.13 106.50 38.63  3.90 N 
13 1 N     A PRO 527 ? ? CD    A PRO 527 ? ? CG  A PRO 527 ? ? 75.97  103.20 -27.23 1.50 N 
14 1 CA    A PRO 762 ? ? N     A PRO 762 ? ? CD  A PRO 762 ? ? 96.79  111.70 -14.91 1.40 N 
15 1 "C3'" C C   12  ? ? "O3'" C C   12  ? ? P   C U   13  ? ? 126.92 119.70 7.22   1.20 Y 
16 1 "O3'" C C   12  ? ? P     C U   13  ? ? OP1 C U   13  ? ? 118.22 110.50 7.72   1.10 Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 LYS A 98  ? ? -131.18 -37.15  
2  1 LYS A 226 ? ? 59.27   -171.78 
3  1 HIS A 271 ? ? -104.26 41.55   
4  1 CYS A 352 ? ? 78.57   -6.74   
5  1 GLU A 447 ? ? -69.45  97.71   
6  1 LYS A 449 ? ? -101.26 -60.42  
7  1 SER A 500 ? ? -101.41 72.38   
8  1 ASN A 623 ? ? -131.62 -37.17  
9  1 LYS A 709 ? ? 71.22   -12.19  
10 1 LYS A 739 ? ? 75.04   -17.35  
11 1 GLN A 757 ? ? 70.64   -16.51  
12 1 HIS A 788 ? ? -92.50  43.13   
13 1 SER A 798 ? ? 70.72   -9.36   
14 1 VAL A 818 ? ? -134.74 -32.12  
15 1 TYR A 857 ? ? -144.61 25.01   
# 
_pdbx_validate_peptide_omega.id               1 
_pdbx_validate_peptide_omega.PDB_model_num    1 
_pdbx_validate_peptide_omega.auth_comp_id_1   ARG 
_pdbx_validate_peptide_omega.auth_asym_id_1   A 
_pdbx_validate_peptide_omega.auth_seq_id_1    761 
_pdbx_validate_peptide_omega.PDB_ins_code_1   ? 
_pdbx_validate_peptide_omega.label_alt_id_1   ? 
_pdbx_validate_peptide_omega.auth_comp_id_2   PRO 
_pdbx_validate_peptide_omega.auth_asym_id_2   A 
_pdbx_validate_peptide_omega.auth_seq_id_2    762 
_pdbx_validate_peptide_omega.PDB_ins_code_2   ? 
_pdbx_validate_peptide_omega.label_alt_id_2   ? 
_pdbx_validate_peptide_omega.omega            147.08 
# 
loop_
_pdbx_validate_planes.id 
_pdbx_validate_planes.PDB_model_num 
_pdbx_validate_planes.auth_comp_id 
_pdbx_validate_planes.auth_asym_id 
_pdbx_validate_planes.auth_seq_id 
_pdbx_validate_planes.PDB_ins_code 
_pdbx_validate_planes.label_alt_id 
_pdbx_validate_planes.rmsd 
_pdbx_validate_planes.type 
1 1 ARG A 792 ? ? 0.081 'SIDE CHAIN' 
2 1 ARG A 812 ? ? 0.292 'SIDE CHAIN' 
3 1 ARG A 814 ? ? 0.278 'SIDE CHAIN' 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9K6P 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    9K6P 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.2 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               35278 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            8.0 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'Complex of hAGO2D669A-siRNA-target (12-nt)' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       '1, 2, 3' 
# 
_em_imaging.entry_id                        9K6P 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'TFS KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             1500 
_em_imaging.nominal_defocus_max             2000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              9K6P 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9K6P 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 1   ? A MET 1   
2  1 Y 1 A TYR 2   ? A TYR 2   
3  1 Y 1 A SER 3   ? A SER 3   
4  1 Y 1 A GLY 4   ? A GLY 4   
5  1 Y 1 A ALA 5   ? A ALA 5   
6  1 Y 1 A GLY 6   ? A GLY 6   
7  1 Y 1 A PRO 7   ? A PRO 7   
8  1 Y 1 A ALA 8   ? A ALA 8   
9  1 Y 1 A LEU 9   ? A LEU 9   
10 1 Y 1 A ALA 10  ? A ALA 10  
11 1 Y 1 A PRO 11  ? A PRO 11  
12 1 Y 1 A PRO 12  ? A PRO 12  
13 1 Y 1 A ALA 13  ? A ALA 13  
14 1 Y 1 A PRO 14  ? A PRO 14  
15 1 Y 1 A PRO 15  ? A PRO 15  
16 1 Y 1 A PRO 16  ? A PRO 16  
17 1 Y 1 A PRO 17  ? A PRO 17  
18 1 Y 1 A ILE 18  ? A ILE 18  
19 1 Y 1 A GLN 19  ? A GLN 19  
20 1 Y 1 A THR 285 ? A THR 285 
21 1 Y 1 A ARG 286 ? A ARG 286 
22 1 Y 1 A ARG 287 ? A ARG 287 
23 1 Y 1 A PRO 288 ? A PRO 288 
24 1 Y 1 A ALA 289 ? A ALA 289 
25 1 Y 1 A SER 290 ? A SER 290 
26 1 Y 1 A HIS 291 ? A HIS 291 
27 1 Y 1 A GLN 292 ? A GLN 292 
28 1 Y 1 A THR 293 ? A THR 293 
29 1 Y 1 A PHE 294 ? A PHE 294 
30 1 Y 1 A PRO 295 ? A PRO 295 
31 1 Y 1 A LEU 296 ? A LEU 296 
32 1 Y 1 A GLN 297 ? A GLN 297 
33 1 Y 1 A GLN 298 ? A GLN 298 
34 1 Y 1 A GLU 299 ? A GLU 299 
35 1 Y 1 A SER 300 ? A SER 300 
36 1 Y 1 A GLY 301 ? A GLY 301 
37 1 Y 1 A GLN 302 ? A GLN 302 
38 1 Y 1 A THR 303 ? A THR 303 
39 1 Y 1 A VAL 304 ? A VAL 304 
40 1 Y 1 A GLU 305 ? A GLU 305 
41 1 Y 1 A CYS 306 ? A CYS 306 
42 1 Y 1 A THR 307 ? A THR 307 
43 1 Y 1 A VAL 308 ? A VAL 308 
44 1 Y 1 A ALA 309 ? A ALA 309 
45 1 Y 1 A GLN 310 ? A GLN 310 
46 1 Y 1 A TYR 311 ? A TYR 311 
47 1 Y 1 A PHE 312 ? A PHE 312 
48 1 Y 1 A LYS 313 ? A LYS 313 
49 1 Y 1 A ASP 314 ? A ASP 314 
50 1 Y 1 A ARG 315 ? A ARG 315 
51 1 Y 1 A HIS 316 ? A HIS 316 
52 1 Y 1 A LYS 317 ? A LYS 317 
53 1 Y 1 A LEU 318 ? A LEU 318 
54 1 Y 1 A VAL 319 ? A VAL 319 
55 1 Y 1 A LEU 320 ? A LEU 320 
56 1 Y 1 A ARG 321 ? A ARG 321 
57 1 Y 1 A TYR 322 ? A TYR 322 
58 1 Y 1 A PRO 323 ? A PRO 323 
59 1 Y 1 A HIS 324 ? A HIS 324 
60 1 Y 1 A LEU 325 ? A LEU 325 
61 1 Y 1 A PRO 326 ? A PRO 326 
62 1 Y 1 A CYS 327 ? A CYS 327 
63 1 Y 1 A HIS 600 ? A HIS 600 
64 1 Y 1 A PRO 601 ? A PRO 601 
65 1 Y 1 A PRO 602 ? A PRO 602 
66 1 Y 1 A ALA 603 ? A ALA 603 
67 1 Y 1 A GLY 604 ? A GLY 604 
68 1 Y 1 A ASP 605 ? A ASP 605 
69 1 Y 1 A GLY 606 ? A GLY 606 
70 1 Y 1 A LYS 607 ? A LYS 607 
71 1 Y 1 A GLU 821 ? A GLU 821 
72 1 Y 1 A HIS 822 ? A HIS 822 
73 1 Y 1 A ASP 823 ? A ASP 823 
74 1 Y 1 A SER 824 ? A SER 824 
75 1 Y 1 A ALA 825 ? A ALA 825 
76 1 Y 1 A GLU 826 ? A GLU 826 
77 1 Y 1 A GLY 827 ? A GLY 827 
78 1 Y 1 A SER 828 ? A SER 828 
79 1 Y 1 A HIS 829 ? A HIS 829 
80 1 Y 1 A THR 830 ? A THR 830 
81 1 Y 1 A SER 831 ? A SER 831 
82 1 Y 1 A GLY 832 ? A GLY 832 
83 1 Y 1 A GLN 833 ? A GLN 833 
84 1 Y 1 A SER 834 ? A SER 834 
85 1 Y 1 A ASN 835 ? A ASN 835 
86 1 Y 1 A GLY 836 ? A GLY 836 
87 1 Y 1 A ARG 837 ? A ARG 837 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A   OP3    O N N 1   
A   P      P N N 2   
A   OP1    O N N 3   
A   OP2    O N N 4   
A   "O5'"  O N N 5   
A   "C5'"  C N N 6   
A   "C4'"  C N R 7   
A   "O4'"  O N N 8   
A   "C3'"  C N S 9   
A   "O3'"  O N N 10  
A   "C2'"  C N R 11  
A   "O2'"  O N N 12  
A   "C1'"  C N R 13  
A   N9     N Y N 14  
A   C8     C Y N 15  
A   N7     N Y N 16  
A   C5     C Y N 17  
A   C6     C Y N 18  
A   N6     N N N 19  
A   N1     N Y N 20  
A   C2     C Y N 21  
A   N3     N Y N 22  
A   C4     C Y N 23  
A   HOP3   H N N 24  
A   HOP2   H N N 25  
A   "H5'"  H N N 26  
A   "H5''" H N N 27  
A   "H4'"  H N N 28  
A   "H3'"  H N N 29  
A   "HO3'" H N N 30  
A   "H2'"  H N N 31  
A   "HO2'" H N N 32  
A   "H1'"  H N N 33  
A   H8     H N N 34  
A   H61    H N N 35  
A   H62    H N N 36  
A   H2     H N N 37  
ALA N      N N N 38  
ALA CA     C N S 39  
ALA C      C N N 40  
ALA O      O N N 41  
ALA CB     C N N 42  
ALA OXT    O N N 43  
ALA H      H N N 44  
ALA H2     H N N 45  
ALA HA     H N N 46  
ALA HB1    H N N 47  
ALA HB2    H N N 48  
ALA HB3    H N N 49  
ALA HXT    H N N 50  
ARG N      N N N 51  
ARG CA     C N S 52  
ARG C      C N N 53  
ARG O      O N N 54  
ARG CB     C N N 55  
ARG CG     C N N 56  
ARG CD     C N N 57  
ARG NE     N N N 58  
ARG CZ     C N N 59  
ARG NH1    N N N 60  
ARG NH2    N N N 61  
ARG OXT    O N N 62  
ARG H      H N N 63  
ARG H2     H N N 64  
ARG HA     H N N 65  
ARG HB2    H N N 66  
ARG HB3    H N N 67  
ARG HG2    H N N 68  
ARG HG3    H N N 69  
ARG HD2    H N N 70  
ARG HD3    H N N 71  
ARG HE     H N N 72  
ARG HH11   H N N 73  
ARG HH12   H N N 74  
ARG HH21   H N N 75  
ARG HH22   H N N 76  
ARG HXT    H N N 77  
ASN N      N N N 78  
ASN CA     C N S 79  
ASN C      C N N 80  
ASN O      O N N 81  
ASN CB     C N N 82  
ASN CG     C N N 83  
ASN OD1    O N N 84  
ASN ND2    N N N 85  
ASN OXT    O N N 86  
ASN H      H N N 87  
ASN H2     H N N 88  
ASN HA     H N N 89  
ASN HB2    H N N 90  
ASN HB3    H N N 91  
ASN HD21   H N N 92  
ASN HD22   H N N 93  
ASN HXT    H N N 94  
ASP N      N N N 95  
ASP CA     C N S 96  
ASP C      C N N 97  
ASP O      O N N 98  
ASP CB     C N N 99  
ASP CG     C N N 100 
ASP OD1    O N N 101 
ASP OD2    O N N 102 
ASP OXT    O N N 103 
ASP H      H N N 104 
ASP H2     H N N 105 
ASP HA     H N N 106 
ASP HB2    H N N 107 
ASP HB3    H N N 108 
ASP HD2    H N N 109 
ASP HXT    H N N 110 
C   OP3    O N N 111 
C   P      P N N 112 
C   OP1    O N N 113 
C   OP2    O N N 114 
C   "O5'"  O N N 115 
C   "C5'"  C N N 116 
C   "C4'"  C N R 117 
C   "O4'"  O N N 118 
C   "C3'"  C N S 119 
C   "O3'"  O N N 120 
C   "C2'"  C N R 121 
C   "O2'"  O N N 122 
C   "C1'"  C N R 123 
C   N1     N N N 124 
C   C2     C N N 125 
C   O2     O N N 126 
C   N3     N N N 127 
C   C4     C N N 128 
C   N4     N N N 129 
C   C5     C N N 130 
C   C6     C N N 131 
C   HOP3   H N N 132 
C   HOP2   H N N 133 
C   "H5'"  H N N 134 
C   "H5''" H N N 135 
C   "H4'"  H N N 136 
C   "H3'"  H N N 137 
C   "HO3'" H N N 138 
C   "H2'"  H N N 139 
C   "HO2'" H N N 140 
C   "H1'"  H N N 141 
C   H41    H N N 142 
C   H42    H N N 143 
C   H5     H N N 144 
C   H6     H N N 145 
CYS N      N N N 146 
CYS CA     C N R 147 
CYS C      C N N 148 
CYS O      O N N 149 
CYS CB     C N N 150 
CYS SG     S N N 151 
CYS OXT    O N N 152 
CYS H      H N N 153 
CYS H2     H N N 154 
CYS HA     H N N 155 
CYS HB2    H N N 156 
CYS HB3    H N N 157 
CYS HG     H N N 158 
CYS HXT    H N N 159 
G   OP3    O N N 160 
G   P      P N N 161 
G   OP1    O N N 162 
G   OP2    O N N 163 
G   "O5'"  O N N 164 
G   "C5'"  C N N 165 
G   "C4'"  C N R 166 
G   "O4'"  O N N 167 
G   "C3'"  C N S 168 
G   "O3'"  O N N 169 
G   "C2'"  C N R 170 
G   "O2'"  O N N 171 
G   "C1'"  C N R 172 
G   N9     N Y N 173 
G   C8     C Y N 174 
G   N7     N Y N 175 
G   C5     C Y N 176 
G   C6     C N N 177 
G   O6     O N N 178 
G   N1     N N N 179 
G   C2     C N N 180 
G   N2     N N N 181 
G   N3     N N N 182 
G   C4     C Y N 183 
G   HOP3   H N N 184 
G   HOP2   H N N 185 
G   "H5'"  H N N 186 
G   "H5''" H N N 187 
G   "H4'"  H N N 188 
G   "H3'"  H N N 189 
G   "HO3'" H N N 190 
G   "H2'"  H N N 191 
G   "HO2'" H N N 192 
G   "H1'"  H N N 193 
G   H8     H N N 194 
G   H1     H N N 195 
G   H21    H N N 196 
G   H22    H N N 197 
GLN N      N N N 198 
GLN CA     C N S 199 
GLN C      C N N 200 
GLN O      O N N 201 
GLN CB     C N N 202 
GLN CG     C N N 203 
GLN CD     C N N 204 
GLN OE1    O N N 205 
GLN NE2    N N N 206 
GLN OXT    O N N 207 
GLN H      H N N 208 
GLN H2     H N N 209 
GLN HA     H N N 210 
GLN HB2    H N N 211 
GLN HB3    H N N 212 
GLN HG2    H N N 213 
GLN HG3    H N N 214 
GLN HE21   H N N 215 
GLN HE22   H N N 216 
GLN HXT    H N N 217 
GLU N      N N N 218 
GLU CA     C N S 219 
GLU C      C N N 220 
GLU O      O N N 221 
GLU CB     C N N 222 
GLU CG     C N N 223 
GLU CD     C N N 224 
GLU OE1    O N N 225 
GLU OE2    O N N 226 
GLU OXT    O N N 227 
GLU H      H N N 228 
GLU H2     H N N 229 
GLU HA     H N N 230 
GLU HB2    H N N 231 
GLU HB3    H N N 232 
GLU HG2    H N N 233 
GLU HG3    H N N 234 
GLU HE2    H N N 235 
GLU HXT    H N N 236 
GLY N      N N N 237 
GLY CA     C N N 238 
GLY C      C N N 239 
GLY O      O N N 240 
GLY OXT    O N N 241 
GLY H      H N N 242 
GLY H2     H N N 243 
GLY HA2    H N N 244 
GLY HA3    H N N 245 
GLY HXT    H N N 246 
HIS N      N N N 247 
HIS CA     C N S 248 
HIS C      C N N 249 
HIS O      O N N 250 
HIS CB     C N N 251 
HIS CG     C Y N 252 
HIS ND1    N Y N 253 
HIS CD2    C Y N 254 
HIS CE1    C Y N 255 
HIS NE2    N Y N 256 
HIS OXT    O N N 257 
HIS H      H N N 258 
HIS H2     H N N 259 
HIS HA     H N N 260 
HIS HB2    H N N 261 
HIS HB3    H N N 262 
HIS HD1    H N N 263 
HIS HD2    H N N 264 
HIS HE1    H N N 265 
HIS HE2    H N N 266 
HIS HXT    H N N 267 
ILE N      N N N 268 
ILE CA     C N S 269 
ILE C      C N N 270 
ILE O      O N N 271 
ILE CB     C N S 272 
ILE CG1    C N N 273 
ILE CG2    C N N 274 
ILE CD1    C N N 275 
ILE OXT    O N N 276 
ILE H      H N N 277 
ILE H2     H N N 278 
ILE HA     H N N 279 
ILE HB     H N N 280 
ILE HG12   H N N 281 
ILE HG13   H N N 282 
ILE HG21   H N N 283 
ILE HG22   H N N 284 
ILE HG23   H N N 285 
ILE HD11   H N N 286 
ILE HD12   H N N 287 
ILE HD13   H N N 288 
ILE HXT    H N N 289 
LEU N      N N N 290 
LEU CA     C N S 291 
LEU C      C N N 292 
LEU O      O N N 293 
LEU CB     C N N 294 
LEU CG     C N N 295 
LEU CD1    C N N 296 
LEU CD2    C N N 297 
LEU OXT    O N N 298 
LEU H      H N N 299 
LEU H2     H N N 300 
LEU HA     H N N 301 
LEU HB2    H N N 302 
LEU HB3    H N N 303 
LEU HG     H N N 304 
LEU HD11   H N N 305 
LEU HD12   H N N 306 
LEU HD13   H N N 307 
LEU HD21   H N N 308 
LEU HD22   H N N 309 
LEU HD23   H N N 310 
LEU HXT    H N N 311 
LYS N      N N N 312 
LYS CA     C N S 313 
LYS C      C N N 314 
LYS O      O N N 315 
LYS CB     C N N 316 
LYS CG     C N N 317 
LYS CD     C N N 318 
LYS CE     C N N 319 
LYS NZ     N N N 320 
LYS OXT    O N N 321 
LYS H      H N N 322 
LYS H2     H N N 323 
LYS HA     H N N 324 
LYS HB2    H N N 325 
LYS HB3    H N N 326 
LYS HG2    H N N 327 
LYS HG3    H N N 328 
LYS HD2    H N N 329 
LYS HD3    H N N 330 
LYS HE2    H N N 331 
LYS HE3    H N N 332 
LYS HZ1    H N N 333 
LYS HZ2    H N N 334 
LYS HZ3    H N N 335 
LYS HXT    H N N 336 
MET N      N N N 337 
MET CA     C N S 338 
MET C      C N N 339 
MET O      O N N 340 
MET CB     C N N 341 
MET CG     C N N 342 
MET SD     S N N 343 
MET CE     C N N 344 
MET OXT    O N N 345 
MET H      H N N 346 
MET H2     H N N 347 
MET HA     H N N 348 
MET HB2    H N N 349 
MET HB3    H N N 350 
MET HG2    H N N 351 
MET HG3    H N N 352 
MET HE1    H N N 353 
MET HE2    H N N 354 
MET HE3    H N N 355 
MET HXT    H N N 356 
PHE N      N N N 357 
PHE CA     C N S 358 
PHE C      C N N 359 
PHE O      O N N 360 
PHE CB     C N N 361 
PHE CG     C Y N 362 
PHE CD1    C Y N 363 
PHE CD2    C Y N 364 
PHE CE1    C Y N 365 
PHE CE2    C Y N 366 
PHE CZ     C Y N 367 
PHE OXT    O N N 368 
PHE H      H N N 369 
PHE H2     H N N 370 
PHE HA     H N N 371 
PHE HB2    H N N 372 
PHE HB3    H N N 373 
PHE HD1    H N N 374 
PHE HD2    H N N 375 
PHE HE1    H N N 376 
PHE HE2    H N N 377 
PHE HZ     H N N 378 
PHE HXT    H N N 379 
PRO N      N N N 380 
PRO CA     C N S 381 
PRO C      C N N 382 
PRO O      O N N 383 
PRO CB     C N N 384 
PRO CG     C N N 385 
PRO CD     C N N 386 
PRO OXT    O N N 387 
PRO H      H N N 388 
PRO HA     H N N 389 
PRO HB2    H N N 390 
PRO HB3    H N N 391 
PRO HG2    H N N 392 
PRO HG3    H N N 393 
PRO HD2    H N N 394 
PRO HD3    H N N 395 
PRO HXT    H N N 396 
SER N      N N N 397 
SER CA     C N S 398 
SER C      C N N 399 
SER O      O N N 400 
SER CB     C N N 401 
SER OG     O N N 402 
SER OXT    O N N 403 
SER H      H N N 404 
SER H2     H N N 405 
SER HA     H N N 406 
SER HB2    H N N 407 
SER HB3    H N N 408 
SER HG     H N N 409 
SER HXT    H N N 410 
THR N      N N N 411 
THR CA     C N S 412 
THR C      C N N 413 
THR O      O N N 414 
THR CB     C N R 415 
THR OG1    O N N 416 
THR CG2    C N N 417 
THR OXT    O N N 418 
THR H      H N N 419 
THR H2     H N N 420 
THR HA     H N N 421 
THR HB     H N N 422 
THR HG1    H N N 423 
THR HG21   H N N 424 
THR HG22   H N N 425 
THR HG23   H N N 426 
THR HXT    H N N 427 
TRP N      N N N 428 
TRP CA     C N S 429 
TRP C      C N N 430 
TRP O      O N N 431 
TRP CB     C N N 432 
TRP CG     C Y N 433 
TRP CD1    C Y N 434 
TRP CD2    C Y N 435 
TRP NE1    N Y N 436 
TRP CE2    C Y N 437 
TRP CE3    C Y N 438 
TRP CZ2    C Y N 439 
TRP CZ3    C Y N 440 
TRP CH2    C Y N 441 
TRP OXT    O N N 442 
TRP H      H N N 443 
TRP H2     H N N 444 
TRP HA     H N N 445 
TRP HB2    H N N 446 
TRP HB3    H N N 447 
TRP HD1    H N N 448 
TRP HE1    H N N 449 
TRP HE3    H N N 450 
TRP HZ2    H N N 451 
TRP HZ3    H N N 452 
TRP HH2    H N N 453 
TRP HXT    H N N 454 
TYR N      N N N 455 
TYR CA     C N S 456 
TYR C      C N N 457 
TYR O      O N N 458 
TYR CB     C N N 459 
TYR CG     C Y N 460 
TYR CD1    C Y N 461 
TYR CD2    C Y N 462 
TYR CE1    C Y N 463 
TYR CE2    C Y N 464 
TYR CZ     C Y N 465 
TYR OH     O N N 466 
TYR OXT    O N N 467 
TYR H      H N N 468 
TYR H2     H N N 469 
TYR HA     H N N 470 
TYR HB2    H N N 471 
TYR HB3    H N N 472 
TYR HD1    H N N 473 
TYR HD2    H N N 474 
TYR HE1    H N N 475 
TYR HE2    H N N 476 
TYR HH     H N N 477 
TYR HXT    H N N 478 
U   OP3    O N N 479 
U   P      P N N 480 
U   OP1    O N N 481 
U   OP2    O N N 482 
U   "O5'"  O N N 483 
U   "C5'"  C N N 484 
U   "C4'"  C N R 485 
U   "O4'"  O N N 486 
U   "C3'"  C N S 487 
U   "O3'"  O N N 488 
U   "C2'"  C N R 489 
U   "O2'"  O N N 490 
U   "C1'"  C N R 491 
U   N1     N N N 492 
U   C2     C N N 493 
U   O2     O N N 494 
U   N3     N N N 495 
U   C4     C N N 496 
U   O4     O N N 497 
U   C5     C N N 498 
U   C6     C N N 499 
U   HOP3   H N N 500 
U   HOP2   H N N 501 
U   "H5'"  H N N 502 
U   "H5''" H N N 503 
U   "H4'"  H N N 504 
U   "H3'"  H N N 505 
U   "HO3'" H N N 506 
U   "H2'"  H N N 507 
U   "HO2'" H N N 508 
U   "H1'"  H N N 509 
U   H3     H N N 510 
U   H5     H N N 511 
U   H6     H N N 512 
VAL N      N N N 513 
VAL CA     C N S 514 
VAL C      C N N 515 
VAL O      O N N 516 
VAL CB     C N N 517 
VAL CG1    C N N 518 
VAL CG2    C N N 519 
VAL OXT    O N N 520 
VAL H      H N N 521 
VAL H2     H N N 522 
VAL HA     H N N 523 
VAL HB     H N N 524 
VAL HG11   H N N 525 
VAL HG12   H N N 526 
VAL HG13   H N N 527 
VAL HG21   H N N 528 
VAL HG22   H N N 529 
VAL HG23   H N N 530 
VAL HXT    H N N 531 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A   OP3   P      sing N N 1   
A   OP3   HOP3   sing N N 2   
A   P     OP1    doub N N 3   
A   P     OP2    sing N N 4   
A   P     "O5'"  sing N N 5   
A   OP2   HOP2   sing N N 6   
A   "O5'" "C5'"  sing N N 7   
A   "C5'" "C4'"  sing N N 8   
A   "C5'" "H5'"  sing N N 9   
A   "C5'" "H5''" sing N N 10  
A   "C4'" "O4'"  sing N N 11  
A   "C4'" "C3'"  sing N N 12  
A   "C4'" "H4'"  sing N N 13  
A   "O4'" "C1'"  sing N N 14  
A   "C3'" "O3'"  sing N N 15  
A   "C3'" "C2'"  sing N N 16  
A   "C3'" "H3'"  sing N N 17  
A   "O3'" "HO3'" sing N N 18  
A   "C2'" "O2'"  sing N N 19  
A   "C2'" "C1'"  sing N N 20  
A   "C2'" "H2'"  sing N N 21  
A   "O2'" "HO2'" sing N N 22  
A   "C1'" N9     sing N N 23  
A   "C1'" "H1'"  sing N N 24  
A   N9    C8     sing Y N 25  
A   N9    C4     sing Y N 26  
A   C8    N7     doub Y N 27  
A   C8    H8     sing N N 28  
A   N7    C5     sing Y N 29  
A   C5    C6     sing Y N 30  
A   C5    C4     doub Y N 31  
A   C6    N6     sing N N 32  
A   C6    N1     doub Y N 33  
A   N6    H61    sing N N 34  
A   N6    H62    sing N N 35  
A   N1    C2     sing Y N 36  
A   C2    N3     doub Y N 37  
A   C2    H2     sing N N 38  
A   N3    C4     sing Y N 39  
ALA N     CA     sing N N 40  
ALA N     H      sing N N 41  
ALA N     H2     sing N N 42  
ALA CA    C      sing N N 43  
ALA CA    CB     sing N N 44  
ALA CA    HA     sing N N 45  
ALA C     O      doub N N 46  
ALA C     OXT    sing N N 47  
ALA CB    HB1    sing N N 48  
ALA CB    HB2    sing N N 49  
ALA CB    HB3    sing N N 50  
ALA OXT   HXT    sing N N 51  
ARG N     CA     sing N N 52  
ARG N     H      sing N N 53  
ARG N     H2     sing N N 54  
ARG CA    C      sing N N 55  
ARG CA    CB     sing N N 56  
ARG CA    HA     sing N N 57  
ARG C     O      doub N N 58  
ARG C     OXT    sing N N 59  
ARG CB    CG     sing N N 60  
ARG CB    HB2    sing N N 61  
ARG CB    HB3    sing N N 62  
ARG CG    CD     sing N N 63  
ARG CG    HG2    sing N N 64  
ARG CG    HG3    sing N N 65  
ARG CD    NE     sing N N 66  
ARG CD    HD2    sing N N 67  
ARG CD    HD3    sing N N 68  
ARG NE    CZ     sing N N 69  
ARG NE    HE     sing N N 70  
ARG CZ    NH1    sing N N 71  
ARG CZ    NH2    doub N N 72  
ARG NH1   HH11   sing N N 73  
ARG NH1   HH12   sing N N 74  
ARG NH2   HH21   sing N N 75  
ARG NH2   HH22   sing N N 76  
ARG OXT   HXT    sing N N 77  
ASN N     CA     sing N N 78  
ASN N     H      sing N N 79  
ASN N     H2     sing N N 80  
ASN CA    C      sing N N 81  
ASN CA    CB     sing N N 82  
ASN CA    HA     sing N N 83  
ASN C     O      doub N N 84  
ASN C     OXT    sing N N 85  
ASN CB    CG     sing N N 86  
ASN CB    HB2    sing N N 87  
ASN CB    HB3    sing N N 88  
ASN CG    OD1    doub N N 89  
ASN CG    ND2    sing N N 90  
ASN ND2   HD21   sing N N 91  
ASN ND2   HD22   sing N N 92  
ASN OXT   HXT    sing N N 93  
ASP N     CA     sing N N 94  
ASP N     H      sing N N 95  
ASP N     H2     sing N N 96  
ASP CA    C      sing N N 97  
ASP CA    CB     sing N N 98  
ASP CA    HA     sing N N 99  
ASP C     O      doub N N 100 
ASP C     OXT    sing N N 101 
ASP CB    CG     sing N N 102 
ASP CB    HB2    sing N N 103 
ASP CB    HB3    sing N N 104 
ASP CG    OD1    doub N N 105 
ASP CG    OD2    sing N N 106 
ASP OD2   HD2    sing N N 107 
ASP OXT   HXT    sing N N 108 
C   OP3   P      sing N N 109 
C   OP3   HOP3   sing N N 110 
C   P     OP1    doub N N 111 
C   P     OP2    sing N N 112 
C   P     "O5'"  sing N N 113 
C   OP2   HOP2   sing N N 114 
C   "O5'" "C5'"  sing N N 115 
C   "C5'" "C4'"  sing N N 116 
C   "C5'" "H5'"  sing N N 117 
C   "C5'" "H5''" sing N N 118 
C   "C4'" "O4'"  sing N N 119 
C   "C4'" "C3'"  sing N N 120 
C   "C4'" "H4'"  sing N N 121 
C   "O4'" "C1'"  sing N N 122 
C   "C3'" "O3'"  sing N N 123 
C   "C3'" "C2'"  sing N N 124 
C   "C3'" "H3'"  sing N N 125 
C   "O3'" "HO3'" sing N N 126 
C   "C2'" "O2'"  sing N N 127 
C   "C2'" "C1'"  sing N N 128 
C   "C2'" "H2'"  sing N N 129 
C   "O2'" "HO2'" sing N N 130 
C   "C1'" N1     sing N N 131 
C   "C1'" "H1'"  sing N N 132 
C   N1    C2     sing N N 133 
C   N1    C6     sing N N 134 
C   C2    O2     doub N N 135 
C   C2    N3     sing N N 136 
C   N3    C4     doub N N 137 
C   C4    N4     sing N N 138 
C   C4    C5     sing N N 139 
C   N4    H41    sing N N 140 
C   N4    H42    sing N N 141 
C   C5    C6     doub N N 142 
C   C5    H5     sing N N 143 
C   C6    H6     sing N N 144 
CYS N     CA     sing N N 145 
CYS N     H      sing N N 146 
CYS N     H2     sing N N 147 
CYS CA    C      sing N N 148 
CYS CA    CB     sing N N 149 
CYS CA    HA     sing N N 150 
CYS C     O      doub N N 151 
CYS C     OXT    sing N N 152 
CYS CB    SG     sing N N 153 
CYS CB    HB2    sing N N 154 
CYS CB    HB3    sing N N 155 
CYS SG    HG     sing N N 156 
CYS OXT   HXT    sing N N 157 
G   OP3   P      sing N N 158 
G   OP3   HOP3   sing N N 159 
G   P     OP1    doub N N 160 
G   P     OP2    sing N N 161 
G   P     "O5'"  sing N N 162 
G   OP2   HOP2   sing N N 163 
G   "O5'" "C5'"  sing N N 164 
G   "C5'" "C4'"  sing N N 165 
G   "C5'" "H5'"  sing N N 166 
G   "C5'" "H5''" sing N N 167 
G   "C4'" "O4'"  sing N N 168 
G   "C4'" "C3'"  sing N N 169 
G   "C4'" "H4'"  sing N N 170 
G   "O4'" "C1'"  sing N N 171 
G   "C3'" "O3'"  sing N N 172 
G   "C3'" "C2'"  sing N N 173 
G   "C3'" "H3'"  sing N N 174 
G   "O3'" "HO3'" sing N N 175 
G   "C2'" "O2'"  sing N N 176 
G   "C2'" "C1'"  sing N N 177 
G   "C2'" "H2'"  sing N N 178 
G   "O2'" "HO2'" sing N N 179 
G   "C1'" N9     sing N N 180 
G   "C1'" "H1'"  sing N N 181 
G   N9    C8     sing Y N 182 
G   N9    C4     sing Y N 183 
G   C8    N7     doub Y N 184 
G   C8    H8     sing N N 185 
G   N7    C5     sing Y N 186 
G   C5    C6     sing N N 187 
G   C5    C4     doub Y N 188 
G   C6    O6     doub N N 189 
G   C6    N1     sing N N 190 
G   N1    C2     sing N N 191 
G   N1    H1     sing N N 192 
G   C2    N2     sing N N 193 
G   C2    N3     doub N N 194 
G   N2    H21    sing N N 195 
G   N2    H22    sing N N 196 
G   N3    C4     sing N N 197 
GLN N     CA     sing N N 198 
GLN N     H      sing N N 199 
GLN N     H2     sing N N 200 
GLN CA    C      sing N N 201 
GLN CA    CB     sing N N 202 
GLN CA    HA     sing N N 203 
GLN C     O      doub N N 204 
GLN C     OXT    sing N N 205 
GLN CB    CG     sing N N 206 
GLN CB    HB2    sing N N 207 
GLN CB    HB3    sing N N 208 
GLN CG    CD     sing N N 209 
GLN CG    HG2    sing N N 210 
GLN CG    HG3    sing N N 211 
GLN CD    OE1    doub N N 212 
GLN CD    NE2    sing N N 213 
GLN NE2   HE21   sing N N 214 
GLN NE2   HE22   sing N N 215 
GLN OXT   HXT    sing N N 216 
GLU N     CA     sing N N 217 
GLU N     H      sing N N 218 
GLU N     H2     sing N N 219 
GLU CA    C      sing N N 220 
GLU CA    CB     sing N N 221 
GLU CA    HA     sing N N 222 
GLU C     O      doub N N 223 
GLU C     OXT    sing N N 224 
GLU CB    CG     sing N N 225 
GLU CB    HB2    sing N N 226 
GLU CB    HB3    sing N N 227 
GLU CG    CD     sing N N 228 
GLU CG    HG2    sing N N 229 
GLU CG    HG3    sing N N 230 
GLU CD    OE1    doub N N 231 
GLU CD    OE2    sing N N 232 
GLU OE2   HE2    sing N N 233 
GLU OXT   HXT    sing N N 234 
GLY N     CA     sing N N 235 
GLY N     H      sing N N 236 
GLY N     H2     sing N N 237 
GLY CA    C      sing N N 238 
GLY CA    HA2    sing N N 239 
GLY CA    HA3    sing N N 240 
GLY C     O      doub N N 241 
GLY C     OXT    sing N N 242 
GLY OXT   HXT    sing N N 243 
HIS N     CA     sing N N 244 
HIS N     H      sing N N 245 
HIS N     H2     sing N N 246 
HIS CA    C      sing N N 247 
HIS CA    CB     sing N N 248 
HIS CA    HA     sing N N 249 
HIS C     O      doub N N 250 
HIS C     OXT    sing N N 251 
HIS CB    CG     sing N N 252 
HIS CB    HB2    sing N N 253 
HIS CB    HB3    sing N N 254 
HIS CG    ND1    sing Y N 255 
HIS CG    CD2    doub Y N 256 
HIS ND1   CE1    doub Y N 257 
HIS ND1   HD1    sing N N 258 
HIS CD2   NE2    sing Y N 259 
HIS CD2   HD2    sing N N 260 
HIS CE1   NE2    sing Y N 261 
HIS CE1   HE1    sing N N 262 
HIS NE2   HE2    sing N N 263 
HIS OXT   HXT    sing N N 264 
ILE N     CA     sing N N 265 
ILE N     H      sing N N 266 
ILE N     H2     sing N N 267 
ILE CA    C      sing N N 268 
ILE CA    CB     sing N N 269 
ILE CA    HA     sing N N 270 
ILE C     O      doub N N 271 
ILE C     OXT    sing N N 272 
ILE CB    CG1    sing N N 273 
ILE CB    CG2    sing N N 274 
ILE CB    HB     sing N N 275 
ILE CG1   CD1    sing N N 276 
ILE CG1   HG12   sing N N 277 
ILE CG1   HG13   sing N N 278 
ILE CG2   HG21   sing N N 279 
ILE CG2   HG22   sing N N 280 
ILE CG2   HG23   sing N N 281 
ILE CD1   HD11   sing N N 282 
ILE CD1   HD12   sing N N 283 
ILE CD1   HD13   sing N N 284 
ILE OXT   HXT    sing N N 285 
LEU N     CA     sing N N 286 
LEU N     H      sing N N 287 
LEU N     H2     sing N N 288 
LEU CA    C      sing N N 289 
LEU CA    CB     sing N N 290 
LEU CA    HA     sing N N 291 
LEU C     O      doub N N 292 
LEU C     OXT    sing N N 293 
LEU CB    CG     sing N N 294 
LEU CB    HB2    sing N N 295 
LEU CB    HB3    sing N N 296 
LEU CG    CD1    sing N N 297 
LEU CG    CD2    sing N N 298 
LEU CG    HG     sing N N 299 
LEU CD1   HD11   sing N N 300 
LEU CD1   HD12   sing N N 301 
LEU CD1   HD13   sing N N 302 
LEU CD2   HD21   sing N N 303 
LEU CD2   HD22   sing N N 304 
LEU CD2   HD23   sing N N 305 
LEU OXT   HXT    sing N N 306 
LYS N     CA     sing N N 307 
LYS N     H      sing N N 308 
LYS N     H2     sing N N 309 
LYS CA    C      sing N N 310 
LYS CA    CB     sing N N 311 
LYS CA    HA     sing N N 312 
LYS C     O      doub N N 313 
LYS C     OXT    sing N N 314 
LYS CB    CG     sing N N 315 
LYS CB    HB2    sing N N 316 
LYS CB    HB3    sing N N 317 
LYS CG    CD     sing N N 318 
LYS CG    HG2    sing N N 319 
LYS CG    HG3    sing N N 320 
LYS CD    CE     sing N N 321 
LYS CD    HD2    sing N N 322 
LYS CD    HD3    sing N N 323 
LYS CE    NZ     sing N N 324 
LYS CE    HE2    sing N N 325 
LYS CE    HE3    sing N N 326 
LYS NZ    HZ1    sing N N 327 
LYS NZ    HZ2    sing N N 328 
LYS NZ    HZ3    sing N N 329 
LYS OXT   HXT    sing N N 330 
MET N     CA     sing N N 331 
MET N     H      sing N N 332 
MET N     H2     sing N N 333 
MET CA    C      sing N N 334 
MET CA    CB     sing N N 335 
MET CA    HA     sing N N 336 
MET C     O      doub N N 337 
MET C     OXT    sing N N 338 
MET CB    CG     sing N N 339 
MET CB    HB2    sing N N 340 
MET CB    HB3    sing N N 341 
MET CG    SD     sing N N 342 
MET CG    HG2    sing N N 343 
MET CG    HG3    sing N N 344 
MET SD    CE     sing N N 345 
MET CE    HE1    sing N N 346 
MET CE    HE2    sing N N 347 
MET CE    HE3    sing N N 348 
MET OXT   HXT    sing N N 349 
PHE N     CA     sing N N 350 
PHE N     H      sing N N 351 
PHE N     H2     sing N N 352 
PHE CA    C      sing N N 353 
PHE CA    CB     sing N N 354 
PHE CA    HA     sing N N 355 
PHE C     O      doub N N 356 
PHE C     OXT    sing N N 357 
PHE CB    CG     sing N N 358 
PHE CB    HB2    sing N N 359 
PHE CB    HB3    sing N N 360 
PHE CG    CD1    doub Y N 361 
PHE CG    CD2    sing Y N 362 
PHE CD1   CE1    sing Y N 363 
PHE CD1   HD1    sing N N 364 
PHE CD2   CE2    doub Y N 365 
PHE CD2   HD2    sing N N 366 
PHE CE1   CZ     doub Y N 367 
PHE CE1   HE1    sing N N 368 
PHE CE2   CZ     sing Y N 369 
PHE CE2   HE2    sing N N 370 
PHE CZ    HZ     sing N N 371 
PHE OXT   HXT    sing N N 372 
PRO N     CA     sing N N 373 
PRO N     CD     sing N N 374 
PRO N     H      sing N N 375 
PRO CA    C      sing N N 376 
PRO CA    CB     sing N N 377 
PRO CA    HA     sing N N 378 
PRO C     O      doub N N 379 
PRO C     OXT    sing N N 380 
PRO CB    CG     sing N N 381 
PRO CB    HB2    sing N N 382 
PRO CB    HB3    sing N N 383 
PRO CG    CD     sing N N 384 
PRO CG    HG2    sing N N 385 
PRO CG    HG3    sing N N 386 
PRO CD    HD2    sing N N 387 
PRO CD    HD3    sing N N 388 
PRO OXT   HXT    sing N N 389 
SER N     CA     sing N N 390 
SER N     H      sing N N 391 
SER N     H2     sing N N 392 
SER CA    C      sing N N 393 
SER CA    CB     sing N N 394 
SER CA    HA     sing N N 395 
SER C     O      doub N N 396 
SER C     OXT    sing N N 397 
SER CB    OG     sing N N 398 
SER CB    HB2    sing N N 399 
SER CB    HB3    sing N N 400 
SER OG    HG     sing N N 401 
SER OXT   HXT    sing N N 402 
THR N     CA     sing N N 403 
THR N     H      sing N N 404 
THR N     H2     sing N N 405 
THR CA    C      sing N N 406 
THR CA    CB     sing N N 407 
THR CA    HA     sing N N 408 
THR C     O      doub N N 409 
THR C     OXT    sing N N 410 
THR CB    OG1    sing N N 411 
THR CB    CG2    sing N N 412 
THR CB    HB     sing N N 413 
THR OG1   HG1    sing N N 414 
THR CG2   HG21   sing N N 415 
THR CG2   HG22   sing N N 416 
THR CG2   HG23   sing N N 417 
THR OXT   HXT    sing N N 418 
TRP N     CA     sing N N 419 
TRP N     H      sing N N 420 
TRP N     H2     sing N N 421 
TRP CA    C      sing N N 422 
TRP CA    CB     sing N N 423 
TRP CA    HA     sing N N 424 
TRP C     O      doub N N 425 
TRP C     OXT    sing N N 426 
TRP CB    CG     sing N N 427 
TRP CB    HB2    sing N N 428 
TRP CB    HB3    sing N N 429 
TRP CG    CD1    doub Y N 430 
TRP CG    CD2    sing Y N 431 
TRP CD1   NE1    sing Y N 432 
TRP CD1   HD1    sing N N 433 
TRP CD2   CE2    doub Y N 434 
TRP CD2   CE3    sing Y N 435 
TRP NE1   CE2    sing Y N 436 
TRP NE1   HE1    sing N N 437 
TRP CE2   CZ2    sing Y N 438 
TRP CE3   CZ3    doub Y N 439 
TRP CE3   HE3    sing N N 440 
TRP CZ2   CH2    doub Y N 441 
TRP CZ2   HZ2    sing N N 442 
TRP CZ3   CH2    sing Y N 443 
TRP CZ3   HZ3    sing N N 444 
TRP CH2   HH2    sing N N 445 
TRP OXT   HXT    sing N N 446 
TYR N     CA     sing N N 447 
TYR N     H      sing N N 448 
TYR N     H2     sing N N 449 
TYR CA    C      sing N N 450 
TYR CA    CB     sing N N 451 
TYR CA    HA     sing N N 452 
TYR C     O      doub N N 453 
TYR C     OXT    sing N N 454 
TYR CB    CG     sing N N 455 
TYR CB    HB2    sing N N 456 
TYR CB    HB3    sing N N 457 
TYR CG    CD1    doub Y N 458 
TYR CG    CD2    sing Y N 459 
TYR CD1   CE1    sing Y N 460 
TYR CD1   HD1    sing N N 461 
TYR CD2   CE2    doub Y N 462 
TYR CD2   HD2    sing N N 463 
TYR CE1   CZ     doub Y N 464 
TYR CE1   HE1    sing N N 465 
TYR CE2   CZ     sing Y N 466 
TYR CE2   HE2    sing N N 467 
TYR CZ    OH     sing N N 468 
TYR OH    HH     sing N N 469 
TYR OXT   HXT    sing N N 470 
U   OP3   P      sing N N 471 
U   OP3   HOP3   sing N N 472 
U   P     OP1    doub N N 473 
U   P     OP2    sing N N 474 
U   P     "O5'"  sing N N 475 
U   OP2   HOP2   sing N N 476 
U   "O5'" "C5'"  sing N N 477 
U   "C5'" "C4'"  sing N N 478 
U   "C5'" "H5'"  sing N N 479 
U   "C5'" "H5''" sing N N 480 
U   "C4'" "O4'"  sing N N 481 
U   "C4'" "C3'"  sing N N 482 
U   "C4'" "H4'"  sing N N 483 
U   "O4'" "C1'"  sing N N 484 
U   "C3'" "O3'"  sing N N 485 
U   "C3'" "C2'"  sing N N 486 
U   "C3'" "H3'"  sing N N 487 
U   "O3'" "HO3'" sing N N 488 
U   "C2'" "O2'"  sing N N 489 
U   "C2'" "C1'"  sing N N 490 
U   "C2'" "H2'"  sing N N 491 
U   "O2'" "HO2'" sing N N 492 
U   "C1'" N1     sing N N 493 
U   "C1'" "H1'"  sing N N 494 
U   N1    C2     sing N N 495 
U   N1    C6     sing N N 496 
U   C2    O2     doub N N 497 
U   C2    N3     sing N N 498 
U   N3    C4     sing N N 499 
U   N3    H3     sing N N 500 
U   C4    O4     doub N N 501 
U   C4    C5     sing N N 502 
U   C5    C6     doub N N 503 
U   C5    H5     sing N N 504 
U   C6    H6     sing N N 505 
VAL N     CA     sing N N 506 
VAL N     H      sing N N 507 
VAL N     H2     sing N N 508 
VAL CA    C      sing N N 509 
VAL CA    CB     sing N N 510 
VAL CA    HA     sing N N 511 
VAL C     O      doub N N 512 
VAL C     OXT    sing N N 513 
VAL CB    CG1    sing N N 514 
VAL CB    CG2    sing N N 515 
VAL CB    HB     sing N N 516 
VAL CG1   HG11   sing N N 517 
VAL CG1   HG12   sing N N 518 
VAL CG1   HG13   sing N N 519 
VAL CG2   HG21   sing N N 520 
VAL CG2   HG22   sing N N 521 
VAL CG2   HG23   sing N N 522 
VAL OXT   HXT    sing N N 523 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-10-22 
_em_admin.deposition_site    PDBJ 
_em_admin.entry_id           9K6P 
_em_admin.last_update        2025-06-25 
_em_admin.map_release_date   2025-06-25 
_em_admin.title              'Cryo-EM Structure of hAGO2D669A-siRNA-target (12-nt)' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          9606 
_em_entity_assembly_recombinant.organism             'Homo sapiens' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         50 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'TFS FALCON 4i (4k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'       ? 1  1 ? ? ? ? 
'IMAGE ACQUISITION'        ? 2  ? ? 1 ? ? 
MASKING                    ? 3  ? ? ? ? ? 
'CTF CORRECTION'           ? 4  1 ? ? ? ? 
'LAYERLINE INDEXING'       ? 5  ? ? ? ? ? 
'DIFFRACTION INDEXING'     ? 6  ? ? ? ? ? 
'MODEL FITTING'            ? 7  ? ? ? ? ? 
'MODEL REFINEMENT'         ? 8  ? ? ? ? ? 
OTHER                      ? 9  ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT' ? 10 1 ? ? ? ? 
'FINAL EULER ASSIGNMENT'   ? 11 1 ? ? ? ? 
CLASSIFICATION             ? 12 1 ? ? ? ? 
RECONSTRUCTION             ? 13 1 ? ? ? ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
loop_
_ndb_struct_conf_na.entry_id 
_ndb_struct_conf_na.feature 
9K6P 'double helix'        
9K6P 'a-form double helix' 
# 
loop_
_ndb_struct_na_base_pair.model_number 
_ndb_struct_na_base_pair.i_label_asym_id 
_ndb_struct_na_base_pair.i_label_comp_id 
_ndb_struct_na_base_pair.i_label_seq_id 
_ndb_struct_na_base_pair.i_symmetry 
_ndb_struct_na_base_pair.j_label_asym_id 
_ndb_struct_na_base_pair.j_label_comp_id 
_ndb_struct_na_base_pair.j_label_seq_id 
_ndb_struct_na_base_pair.j_symmetry 
_ndb_struct_na_base_pair.shear 
_ndb_struct_na_base_pair.stretch 
_ndb_struct_na_base_pair.stagger 
_ndb_struct_na_base_pair.buckle 
_ndb_struct_na_base_pair.propeller 
_ndb_struct_na_base_pair.opening 
_ndb_struct_na_base_pair.pair_number 
_ndb_struct_na_base_pair.pair_name 
_ndb_struct_na_base_pair.i_auth_asym_id 
_ndb_struct_na_base_pair.i_auth_seq_id 
_ndb_struct_na_base_pair.i_PDB_ins_code 
_ndb_struct_na_base_pair.j_auth_asym_id 
_ndb_struct_na_base_pair.j_auth_seq_id 
_ndb_struct_na_base_pair.j_PDB_ins_code 
_ndb_struct_na_base_pair.hbond_type_28 
_ndb_struct_na_base_pair.hbond_type_12 
1 B A 2 1_555 C U 9 1_555 0.807  5.349  0.989  -40.698 -3.799  -76.931 1 B_A2:U18_C B 2 ? C 18 ? ?  3 
1 B C 3 1_555 C G 8 1_555 0.212  -0.099 -0.112 4.094   -10.787 2.437   2 B_C3:G17_C B 3 ? C 17 ? 19 1 
1 B A 4 1_555 C U 7 1_555 0.047  -0.040 -0.272 -4.080  0.423   -0.207  3 B_A4:U16_C B 4 ? C 16 ? 20 1 
1 B A 5 1_555 C U 6 1_555 0.064  -0.193 0.262  4.941   4.217   5.388   4 B_A5:U15_C B 5 ? C 15 ? 20 1 
1 B G 6 1_555 C C 5 1_555 -0.111 -0.152 -0.321 10.994  -7.295  -1.661  5 B_G6:C14_C B 6 ? C 14 ? 19 1 
1 B A 7 1_555 C U 4 1_555 0.101  -0.236 -0.138 5.922   -22.852 4.009   6 B_A7:U13_C B 7 ? C 13 ? 20 1 
1 B G 8 1_555 C C 3 1_555 -0.232 -0.251 -0.110 9.624   -23.108 6.767   7 B_G8:C12_C B 8 ? C 12 ? 19 1 
# 
loop_
_ndb_struct_na_base_pair_step.model_number 
_ndb_struct_na_base_pair_step.i_label_asym_id_1 
_ndb_struct_na_base_pair_step.i_label_comp_id_1 
_ndb_struct_na_base_pair_step.i_label_seq_id_1 
_ndb_struct_na_base_pair_step.i_symmetry_1 
_ndb_struct_na_base_pair_step.j_label_asym_id_1 
_ndb_struct_na_base_pair_step.j_label_comp_id_1 
_ndb_struct_na_base_pair_step.j_label_seq_id_1 
_ndb_struct_na_base_pair_step.j_symmetry_1 
_ndb_struct_na_base_pair_step.i_label_asym_id_2 
_ndb_struct_na_base_pair_step.i_label_comp_id_2 
_ndb_struct_na_base_pair_step.i_label_seq_id_2 
_ndb_struct_na_base_pair_step.i_symmetry_2 
_ndb_struct_na_base_pair_step.j_label_asym_id_2 
_ndb_struct_na_base_pair_step.j_label_comp_id_2 
_ndb_struct_na_base_pair_step.j_label_seq_id_2 
_ndb_struct_na_base_pair_step.j_symmetry_2 
_ndb_struct_na_base_pair_step.shift 
_ndb_struct_na_base_pair_step.slide 
_ndb_struct_na_base_pair_step.rise 
_ndb_struct_na_base_pair_step.tilt 
_ndb_struct_na_base_pair_step.roll 
_ndb_struct_na_base_pair_step.twist 
_ndb_struct_na_base_pair_step.x_displacement 
_ndb_struct_na_base_pair_step.y_displacement 
_ndb_struct_na_base_pair_step.helical_rise 
_ndb_struct_na_base_pair_step.inclination 
_ndb_struct_na_base_pair_step.tip 
_ndb_struct_na_base_pair_step.helical_twist 
_ndb_struct_na_base_pair_step.step_number 
_ndb_struct_na_base_pair_step.step_name 
_ndb_struct_na_base_pair_step.i_auth_asym_id_1 
_ndb_struct_na_base_pair_step.i_auth_seq_id_1 
_ndb_struct_na_base_pair_step.i_PDB_ins_code_1 
_ndb_struct_na_base_pair_step.j_auth_asym_id_1 
_ndb_struct_na_base_pair_step.j_auth_seq_id_1 
_ndb_struct_na_base_pair_step.j_PDB_ins_code_1 
_ndb_struct_na_base_pair_step.i_auth_asym_id_2 
_ndb_struct_na_base_pair_step.i_auth_seq_id_2 
_ndb_struct_na_base_pair_step.i_PDB_ins_code_2 
_ndb_struct_na_base_pair_step.j_auth_asym_id_2 
_ndb_struct_na_base_pair_step.j_auth_seq_id_2 
_ndb_struct_na_base_pair_step.j_PDB_ins_code_2 
1 B A 2 1_555 C U 9 1_555 B C 3 1_555 C G 8 1_555 0.017  2.467  3.823 -11.390 2.964   -9.620 -11.938 -9.944 1.958 -12.810 -49.230 
-15.189 1 BB_A2C3:G17U18_CC B 2 ? C 18 ? B 3 ? C 17 ? 
1 B C 3 1_555 C G 8 1_555 B A 4 1_555 C U 7 1_555 -0.981 -1.804 3.565 -6.353  7.274   25.018 -5.874  0.388  3.080 16.048  14.017  
26.790  2 BB_C3A4:U16G17_CC B 3 ? C 17 ? B 4 ? C 16 ? 
1 B A 4 1_555 C U 7 1_555 B A 5 1_555 C U 6 1_555 -0.134 -1.096 3.133 -5.109  9.767   31.301 -3.423  -0.550 2.669 17.438  9.122   
33.139  3 BB_A4A5:U15U16_CC B 4 ? C 16 ? B 5 ? C 15 ? 
1 B A 5 1_555 C U 6 1_555 B G 6 1_555 C C 5 1_555 -0.331 -0.405 3.487 5.931   20.769  26.459 -4.090  1.535  2.428 38.282  -10.931 
34.033  4 BB_A5G6:C14U15_CC B 5 ? C 15 ? B 6 ? C 14 ? 
1 B G 6 1_555 C C 5 1_555 B A 7 1_555 C U 4 1_555 -1.168 1.030  3.719 2.839   -3.886  37.270 2.161   2.223  3.503 -6.049  -4.419  
37.569  5 BB_G6A7:U13C14_CC B 6 ? C 14 ? B 7 ? C 13 ? 
1 B A 7 1_555 C U 4 1_555 B G 8 1_555 C C 3 1_555 2.201  0.212  4.828 2.597   -11.123 18.846 6.995   -4.260 4.292 -30.596 -7.143  
22.010  6 BB_A7G8:C12U13_CC B 7 ? C 13 ? B 8 ? C 12 ? 
# 
_pdbx_audit_support.funding_organization   'Other private' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    9K6P 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
P 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM 1    N N     . GLY A 1 20  ? 84.523  125.701 105.421 1.00 101.79 ? 20  GLY A N     1 
ATOM 2    C CA    . GLY A 1 20  ? 84.084  124.919 106.562 1.00 103.07 ? 20  GLY A CA    1 
ATOM 3    C C     . GLY A 1 20  ? 85.193  124.616 107.549 1.00 104.98 ? 20  GLY A C     1 
ATOM 4    O O     . GLY A 1 20  ? 84.940  124.387 108.732 1.00 106.25 ? 20  GLY A O     1 
ATOM 5    N N     . TYR A 1 21  ? 86.430  124.612 107.058 1.00 91.81  ? 21  TYR A N     1 
ATOM 6    C CA    . TYR A 1 21  ? 87.599  124.335 107.893 1.00 90.86  ? 21  TYR A CA    1 
ATOM 7    C C     . TYR A 1 21  ? 88.216  125.640 108.400 1.00 84.05  ? 21  TYR A C     1 
ATOM 8    O O     . TYR A 1 21  ? 89.366  125.978 108.121 1.00 80.96  ? 21  TYR A O     1 
ATOM 9    C CB    . TYR A 1 21  ? 88.613  123.500 107.119 1.00 91.09  ? 21  TYR A CB    1 
ATOM 10   C CG    . TYR A 1 21  ? 88.366  122.009 107.190 1.00 87.05  ? 21  TYR A CG    1 
ATOM 11   C CD1   . TYR A 1 21  ? 87.626  121.454 108.232 1.00 87.15  ? 21  TYR A CD1   1 
ATOM 12   C CD2   . TYR A 1 21  ? 88.857  121.157 106.206 1.00 83.53  ? 21  TYR A CD2   1 
ATOM 13   C CE1   . TYR A 1 21  ? 87.393  120.090 108.298 1.00 87.92  ? 21  TYR A CE1   1 
ATOM 14   C CE2   . TYR A 1 21  ? 88.626  119.792 106.261 1.00 84.17  ? 21  TYR A CE2   1 
ATOM 15   C CZ    . TYR A 1 21  ? 87.897  119.265 107.310 1.00 88.58  ? 21  TYR A CZ    1 
ATOM 16   O OH    . TYR A 1 21  ? 87.667  117.909 107.369 1.00 90.95  ? 21  TYR A OH    1 
ATOM 17   N N     . ALA A 1 22  ? 87.412  126.381 109.165 1.00 78.90  ? 22  ALA A N     1 
ATOM 18   C CA    . ALA A 1 22  ? 87.869  127.633 109.753 1.00 82.81  ? 22  ALA A CA    1 
ATOM 19   C C     . ALA A 1 22  ? 88.657  127.428 111.039 1.00 80.03  ? 22  ALA A C     1 
ATOM 20   O O     . ALA A 1 22  ? 89.220  128.397 111.559 1.00 79.64  ? 22  ALA A O     1 
ATOM 21   C CB    . ALA A 1 22  ? 86.679  128.556 110.018 1.00 83.24  ? 22  ALA A CB    1 
ATOM 22   N N     . PHE A 1 23  ? 88.713  126.202 111.564 1.00 68.90  ? 23  PHE A N     1 
ATOM 23   C CA    . PHE A 1 23  ? 89.513  125.901 112.750 1.00 68.94  ? 23  PHE A CA    1 
ATOM 24   C C     . PHE A 1 23  ? 90.955  125.646 112.305 1.00 70.47  ? 23  PHE A C     1 
ATOM 25   O O     . PHE A 1 23  ? 91.424  124.514 112.177 1.00 73.15  ? 23  PHE A O     1 
ATOM 26   C CB    . PHE A 1 23  ? 88.924  124.718 113.505 1.00 68.39  ? 23  PHE A CB    1 
ATOM 27   C CG    . PHE A 1 23  ? 89.550  124.483 114.850 1.00 67.38  ? 23  PHE A CG    1 
ATOM 28   C CD1   . PHE A 1 23  ? 89.925  125.555 115.649 1.00 67.52  ? 23  PHE A CD1   1 
ATOM 29   C CD2   . PHE A 1 23  ? 89.743  123.195 115.325 1.00 65.89  ? 23  PHE A CD2   1 
ATOM 30   C CE1   . PHE A 1 23  ? 90.495  125.346 116.892 1.00 67.96  ? 23  PHE A CE1   1 
ATOM 31   C CE2   . PHE A 1 23  ? 90.310  122.982 116.568 1.00 66.53  ? 23  PHE A CE2   1 
ATOM 32   C CZ    . PHE A 1 23  ? 90.688  124.058 117.351 1.00 65.33  ? 23  PHE A CZ    1 
ATOM 33   N N     . LYS A 1 24  ? 91.650  126.744 112.057 1.00 56.41  ? 24  LYS A N     1 
ATOM 34   C CA    . LYS A 1 24  ? 92.972  126.854 111.467 1.00 53.20  ? 24  LYS A CA    1 
ATOM 35   C C     . LYS A 1 24  ? 94.028  127.047 112.546 1.00 55.00  ? 24  LYS A C     1 
ATOM 36   O O     . LYS A 1 24  ? 93.711  127.468 113.663 1.00 60.21  ? 24  LYS A O     1 
ATOM 37   C CB    . LYS A 1 24  ? 92.996  128.040 110.490 1.00 58.84  ? 24  LYS A CB    1 
ATOM 38   C CG    . LYS A 1 24  ? 92.209  127.808 109.213 1.00 60.51  ? 24  LYS A CG    1 
ATOM 39   C CD    . LYS A 1 24  ? 92.981  128.301 108.005 1.00 49.61  ? 24  LYS A CD    1 
ATOM 40   C CE    . LYS A 1 24  ? 94.272  127.518 107.823 1.00 49.52  ? 24  LYS A CE    1 
ATOM 41   N NZ    . LYS A 1 24  ? 94.040  126.048 107.837 1.00 61.88  ? 24  LYS A NZ    1 
ATOM 42   N N     . PRO A 1 25  ? 95.291  126.712 112.273 1.00 50.38  ? 25  PRO A N     1 
ATOM 43   C CA    . PRO A 1 25  ? 96.376  127.160 113.159 1.00 49.31  ? 25  PRO A CA    1 
ATOM 44   C C     . PRO A 1 25  ? 96.502  128.671 113.124 1.00 48.12  ? 25  PRO A C     1 
ATOM 45   O O     . PRO A 1 25  ? 96.363  129.284 112.055 1.00 51.50  ? 25  PRO A O     1 
ATOM 46   C CB    . PRO A 1 25  ? 97.632  126.480 112.588 1.00 41.19  ? 25  PRO A CB    1 
ATOM 47   C CG    . PRO A 1 25  ? 97.165  125.490 111.611 1.00 45.10  ? 25  PRO A CG    1 
ATOM 48   C CD    . PRO A 1 25  ? 95.783  125.841 111.189 1.00 46.44  ? 25  PRO A CD    1 
ATOM 49   N N     . PRO A 1 26  ? 96.743  129.306 114.269 1.00 62.93  ? 26  PRO A N     1 
ATOM 50   C CA    . PRO A 1 26  ? 96.787  130.766 114.314 1.00 65.58  ? 26  PRO A CA    1 
ATOM 51   C C     . PRO A 1 26  ? 98.064  131.292 113.687 1.00 64.13  ? 26  PRO A C     1 
ATOM 52   O O     . PRO A 1 26  ? 99.059  130.557 113.583 1.00 69.56  ? 26  PRO A O     1 
ATOM 53   C CB    . PRO A 1 26  ? 96.738  131.074 115.817 1.00 62.79  ? 26  PRO A CB    1 
ATOM 54   C CG    . PRO A 1 26  ? 97.359  129.889 116.450 1.00 60.46  ? 26  PRO A CG    1 
ATOM 55   C CD    . PRO A 1 26  ? 96.979  128.711 115.597 1.00 64.30  ? 26  PRO A CD    1 
ATOM 56   N N     . PRO A 1 27  ? 98.055  132.538 113.214 1.00 62.18  ? 27  PRO A N     1 
ATOM 57   C CA    . PRO A 1 27  ? 99.307  133.185 112.810 1.00 63.67  ? 27  PRO A CA    1 
ATOM 58   C C     . PRO A 1 27  ? 100.239 133.362 114.000 1.00 57.72  ? 27  PRO A C     1 
ATOM 59   O O     . PRO A 1 27  ? 99.800  133.471 115.147 1.00 57.85  ? 27  PRO A O     1 
ATOM 60   C CB    . PRO A 1 27  ? 98.850  134.539 112.252 1.00 63.48  ? 27  PRO A CB    1 
ATOM 61   C CG    . PRO A 1 27  ? 97.381  134.645 112.561 1.00 64.72  ? 27  PRO A CG    1 
ATOM 62   C CD    . PRO A 1 27  ? 96.876  133.257 112.709 1.00 58.85  ? 27  PRO A CD    1 
ATOM 63   N N     . ARG A 1 28  ? 101.533 133.356 113.714 1.00 38.94  ? 28  ARG A N     1 
ATOM 64   C CA    . ARG A 1 28  ? 102.534 133.551 114.748 1.00 40.49  ? 28  ARG A CA    1 
ATOM 65   C C     . ARG A 1 28  ? 102.468 134.989 115.261 1.00 47.15  ? 28  ARG A C     1 
ATOM 66   O O     . ARG A 1 28  ? 102.399 135.930 114.455 1.00 54.25  ? 28  ARG A O     1 
ATOM 67   C CB    . ARG A 1 28  ? 103.915 133.211 114.189 1.00 40.42  ? 28  ARG A CB    1 
ATOM 68   C CG    . ARG A 1 28  ? 105.058 134.075 114.646 1.00 45.45  ? 28  ARG A CG    1 
ATOM 69   C CD    . ARG A 1 28  ? 106.332 133.615 113.993 1.00 38.23  ? 28  ARG A CD    1 
ATOM 70   N NE    . ARG A 1 28  ? 106.765 132.350 114.564 1.00 44.06  ? 28  ARG A NE    1 
ATOM 71   C CZ    . ARG A 1 28  ? 107.459 132.242 115.686 1.00 49.18  ? 28  ARG A CZ    1 
ATOM 72   N NH1   . ARG A 1 28  ? 107.873 133.311 116.346 1.00 44.85  ? 28  ARG A NH1   1 
ATOM 73   N NH2   . ARG A 1 28  ? 107.758 131.032 116.149 1.00 50.36  ? 28  ARG A NH2   1 
ATOM 74   N N     . PRO A 1 29  ? 102.404 135.199 116.580 1.00 39.82  ? 29  PRO A N     1 
ATOM 75   C CA    . PRO A 1 29  ? 102.273 136.577 117.081 1.00 40.29  ? 29  PRO A CA    1 
ATOM 76   C C     . PRO A 1 29  ? 103.563 137.376 117.020 1.00 43.88  ? 29  PRO A C     1 
ATOM 77   O O     . PRO A 1 29  ? 103.531 138.556 116.650 1.00 47.88  ? 29  PRO A O     1 
ATOM 78   C CB    . PRO A 1 29  ? 101.786 136.378 118.523 1.00 45.42  ? 29  PRO A CB    1 
ATOM 79   C CG    . PRO A 1 29  ? 102.263 135.017 118.907 1.00 48.58  ? 29  PRO A CG    1 
ATOM 80   C CD    . PRO A 1 29  ? 102.301 134.193 117.652 1.00 45.41  ? 29  PRO A CD    1 
ATOM 81   N N     . ASP A 1 30  ? 104.700 136.775 117.364 1.00 42.59  ? 30  ASP A N     1 
ATOM 82   C CA    . ASP A 1 30  ? 105.930 137.539 117.507 1.00 42.50  ? 30  ASP A CA    1 
ATOM 83   C C     . ASP A 1 30  ? 107.111 136.636 117.191 1.00 38.77  ? 30  ASP A C     1 
ATOM 84   O O     . ASP A 1 30  ? 107.109 135.444 117.509 1.00 32.42  ? 30  ASP A O     1 
ATOM 85   C CB    . ASP A 1 30  ? 106.047 138.127 118.920 1.00 43.52  ? 30  ASP A CB    1 
ATOM 86   C CG    . ASP A 1 30  ? 107.368 138.833 119.159 1.00 48.58  ? 30  ASP A CG    1 
ATOM 87   O OD1   . ASP A 1 30  ? 107.862 139.508 118.230 1.00 40.48  ? 30  ASP A OD1   1 
ATOM 88   O OD2   . ASP A 1 30  ? 107.915 138.708 120.274 1.00 52.94  ? 30  ASP A OD2   1 
ATOM 89   N N     . PHE A 1 31  ? 108.114 137.223 116.547 1.00 43.56  ? 31  PHE A N     1 
ATOM 90   C CA    . PHE A 1 31  ? 109.363 136.535 116.272 1.00 47.21  ? 31  PHE A CA    1 
ATOM 91   C C     . PHE A 1 31  ? 110.176 136.383 117.556 1.00 42.99  ? 31  PHE A C     1 
ATOM 92   O O     . PHE A 1 31  ? 109.947 137.064 118.558 1.00 41.55  ? 31  PHE A O     1 
ATOM 93   C CB    . PHE A 1 31  ? 110.164 137.290 115.211 1.00 42.79  ? 31  PHE A CB    1 
ATOM 94   C CG    . PHE A 1 31  ? 109.878 136.849 113.802 1.00 42.89  ? 31  PHE A CG    1 
ATOM 95   C CD1   . PHE A 1 31  ? 108.576 136.788 113.328 1.00 45.26  ? 31  PHE A CD1   1 
ATOM 96   C CD2   . PHE A 1 31  ? 110.914 136.501 112.952 1.00 42.99  ? 31  PHE A CD2   1 
ATOM 97   C CE1   . PHE A 1 31  ? 108.313 136.380 112.034 1.00 45.40  ? 31  PHE A CE1   1 
ATOM 98   C CE2   . PHE A 1 31  ? 110.659 136.092 111.655 1.00 42.06  ? 31  PHE A CE2   1 
ATOM 99   C CZ    . PHE A 1 31  ? 109.358 136.031 111.197 1.00 45.12  ? 31  PHE A CZ    1 
ATOM 100  N N     . GLY A 1 32  ? 111.142 135.469 117.521 1.00 27.19  ? 32  GLY A N     1 
ATOM 101  C CA    . GLY A 1 32  ? 111.950 135.179 118.690 1.00 25.60  ? 32  GLY A CA    1 
ATOM 102  C C     . GLY A 1 32  ? 113.171 136.080 118.775 1.00 31.45  ? 32  GLY A C     1 
ATOM 103  O O     . GLY A 1 32  ? 113.763 136.444 117.762 1.00 32.09  ? 32  GLY A O     1 
ATOM 104  N N     . THR A 1 33  ? 113.550 136.423 120.014 1.00 37.05  ? 33  THR A N     1 
ATOM 105  C CA    . THR A 1 33  ? 114.713 137.265 120.287 1.00 32.87  ? 33  THR A CA    1 
ATOM 106  C C     . THR A 1 33  ? 115.638 136.724 121.369 1.00 30.00  ? 33  THR A C     1 
ATOM 107  O O     . THR A 1 33  ? 116.667 137.354 121.636 1.00 31.17  ? 33  THR A O     1 
ATOM 108  C CB    . THR A 1 33  ? 114.282 138.683 120.706 1.00 32.11  ? 33  THR A CB    1 
ATOM 109  O OG1   . THR A 1 33  ? 113.300 138.603 121.747 1.00 31.82  ? 33  THR A OG1   1 
ATOM 110  C CG2   . THR A 1 33  ? 113.721 139.473 119.525 1.00 35.04  ? 33  THR A CG2   1 
ATOM 111  N N     . SER A 1 34  ? 115.319 135.590 121.989 1.00 19.53  ? 34  SER A N     1 
ATOM 112  C CA    . SER A 1 34  ? 116.016 135.146 123.189 1.00 19.25  ? 34  SER A CA    1 
ATOM 113  C C     . SER A 1 34  ? 117.368 134.523 122.839 1.00 19.61  ? 34  SER A C     1 
ATOM 114  O O     . SER A 1 34  ? 117.663 134.208 121.688 1.00 16.06  ? 34  SER A O     1 
ATOM 115  C CB    . SER A 1 34  ? 115.149 134.153 123.958 1.00 19.93  ? 34  SER A CB    1 
ATOM 116  O OG    . SER A 1 34  ? 113.827 134.640 124.103 1.00 18.78  ? 34  SER A OG    1 
ATOM 117  N N     . GLY A 1 35  ? 118.213 134.360 123.855 1.00 16.84  ? 35  GLY A N     1 
ATOM 118  C CA    . GLY A 1 35  ? 119.485 133.682 123.690 1.00 8.80   ? 35  GLY A CA    1 
ATOM 119  C C     . GLY A 1 35  ? 120.490 134.460 122.868 1.00 21.01  ? 35  GLY A C     1 
ATOM 120  O O     . GLY A 1 35  ? 120.260 135.629 122.547 1.00 32.11  ? 35  GLY A O     1 
ATOM 121  N N     . ARG A 1 36  ? 121.600 133.827 122.503 1.00 23.47  ? 36  ARG A N     1 
ATOM 122  C CA    . ARG A 1 36  ? 122.575 134.481 121.642 1.00 33.62  ? 36  ARG A CA    1 
ATOM 123  C C     . ARG A 1 36  ? 122.190 134.270 120.182 1.00 28.20  ? 36  ARG A C     1 
ATOM 124  O O     . ARG A 1 36  ? 121.817 133.165 119.777 1.00 23.56  ? 36  ARG A O     1 
ATOM 125  C CB    . ARG A 1 36  ? 123.989 133.966 121.925 1.00 30.34  ? 36  ARG A CB    1 
ATOM 126  C CG    . ARG A 1 36  ? 124.154 132.458 121.936 1.00 27.59  ? 36  ARG A CG    1 
ATOM 127  C CD    . ARG A 1 36  ? 125.527 132.048 122.443 1.00 28.86  ? 36  ARG A CD    1 
ATOM 128  N NE    . ARG A 1 36  ? 126.115 130.979 121.645 1.00 27.55  ? 36  ARG A NE    1 
ATOM 129  C CZ    . ARG A 1 36  ? 127.164 130.258 122.014 1.00 23.46  ? 36  ARG A CZ    1 
ATOM 130  N NH1   . ARG A 1 36  ? 127.746 130.436 123.188 1.00 25.81  ? 36  ARG A NH1   1 
ATOM 131  N NH2   . ARG A 1 36  ? 127.637 129.329 121.189 1.00 19.71  ? 36  ARG A NH2   1 
ATOM 132  N N     . THR A 1 37  ? 122.244 135.345 119.403 1.00 35.51  ? 37  THR A N     1 
ATOM 133  C CA    . THR A 1 37  ? 121.879 135.271 117.998 1.00 30.47  ? 37  THR A CA    1 
ATOM 134  C C     . THR A 1 37  ? 123.048 134.734 117.181 1.00 37.09  ? 37  THR A C     1 
ATOM 135  O O     . THR A 1 37  ? 124.199 135.144 117.357 1.00 31.52  ? 37  THR A O     1 
ATOM 136  C CB    . THR A 1 37  ? 121.460 136.650 117.491 1.00 38.59  ? 37  THR A CB    1 
ATOM 137  O OG1   . THR A 1 37  ? 120.663 137.301 118.488 1.00 43.38  ? 37  THR A OG1   1 
ATOM 138  C CG2   . THR A 1 37  ? 120.644 136.534 116.228 1.00 35.52  ? 37  THR A CG2   1 
ATOM 139  N N     . ILE A 1 38  ? 122.748 133.797 116.284 1.00 50.51  ? 38  ILE A N     1 
ATOM 140  C CA    . ILE A 1 38  ? 123.765 133.163 115.454 1.00 52.67  ? 38  ILE A CA    1 
ATOM 141  C C     . ILE A 1 38  ? 123.365 133.339 113.994 1.00 44.20  ? 38  ILE A C     1 
ATOM 142  O O     . ILE A 1 38  ? 122.181 133.506 113.679 1.00 43.64  ? 38  ILE A O     1 
ATOM 143  C CB    . ILE A 1 38  ? 123.969 131.674 115.826 1.00 43.68  ? 38  ILE A CB    1 
ATOM 144  C CG1   . ILE A 1 38  ? 125.374 131.190 115.441 1.00 42.49  ? 38  ILE A CG1   1 
ATOM 145  C CG2   . ILE A 1 38  ? 122.880 130.759 115.242 1.00 28.52  ? 38  ILE A CG2   1 
ATOM 146  C CD1   . ILE A 1 38  ? 125.644 129.737 115.764 1.00 39.80  ? 38  ILE A CD1   1 
ATOM 147  N N     . LYS A 1 39  ? 124.358 133.377 113.119 1.00 41.96  ? 39  LYS A N     1 
ATOM 148  C CA    . LYS A 1 39  ? 124.159 133.457 111.679 1.00 48.60  ? 39  LYS A CA    1 
ATOM 149  C C     . LYS A 1 39  ? 124.595 132.118 111.079 1.00 49.95  ? 39  LYS A C     1 
ATOM 150  O O     . LYS A 1 39  ? 125.782 131.856 110.880 1.00 55.80  ? 39  LYS A O     1 
ATOM 151  C CB    . LYS A 1 39  ? 124.884 134.681 111.102 1.00 49.00  ? 39  LYS A CB    1 
ATOM 152  C CG    . LYS A 1 39  ? 126.335 134.908 111.558 1.00 48.01  ? 39  LYS A CG    1 
ATOM 153  C CD    . LYS A 1 39  ? 127.064 135.887 110.661 1.00 50.50  ? 39  LYS A CD    1 
ATOM 154  C CE    . LYS A 1 39  ? 128.560 135.875 110.940 1.00 48.63  ? 39  LYS A CE    1 
ATOM 155  N NZ    . LYS A 1 39  ? 129.029 134.577 111.506 1.00 45.53  ? 39  LYS A NZ    1 
ATOM 156  N N     . LEU A 1 40  ? 123.627 131.248 110.820 1.00 40.00  ? 40  LEU A N     1 
ATOM 157  C CA    . LEU A 1 40  ? 123.927 129.883 110.419 1.00 40.97  ? 40  LEU A CA    1 
ATOM 158  C C     . LEU A 1 40  ? 123.866 129.753 108.903 1.00 39.59  ? 40  LEU A C     1 
ATOM 159  O O     . LEU A 1 40  ? 123.401 130.649 108.193 1.00 44.94  ? 40  LEU A O     1 
ATOM 160  C CB    . LEU A 1 40  ? 122.967 128.898 111.101 1.00 52.84  ? 40  LEU A CB    1 
ATOM 161  C CG    . LEU A 1 40  ? 123.559 127.631 111.738 1.00 50.25  ? 40  LEU A CG    1 
ATOM 162  C CD1   . LEU A 1 40  ? 124.906 127.896 112.373 1.00 54.15  ? 40  LEU A CD1   1 
ATOM 163  C CD2   . LEU A 1 40  ? 122.622 127.044 112.773 1.00 43.63  ? 40  LEU A CD2   1 
ATOM 164  N N     . GLN A 1 41  ? 124.379 128.626 108.410 1.00 52.67  ? 41  GLN A N     1 
ATOM 165  C CA    . GLN A 1 41  ? 124.257 128.235 107.008 1.00 54.58  ? 41  GLN A CA    1 
ATOM 166  C C     . GLN A 1 41  ? 123.358 127.008 106.942 1.00 58.30  ? 41  GLN A C     1 
ATOM 167  O O     . GLN A 1 41  ? 123.785 125.899 107.276 1.00 51.02  ? 41  GLN A O     1 
ATOM 168  C CB    . GLN A 1 41  ? 125.617 127.948 106.375 1.00 50.22  ? 41  GLN A CB    1 
ATOM 169  C CG    . GLN A 1 41  ? 126.559 129.133 106.333 1.00 57.60  ? 41  GLN A CG    1 
ATOM 170  C CD    . GLN A 1 41  ? 127.969 128.733 105.960 1.00 57.34  ? 41  GLN A CD    1 
ATOM 171  O OE1   . GLN A 1 41  ? 128.229 127.578 105.628 1.00 53.94  ? 41  GLN A OE1   1 
ATOM 172  N NE2   . GLN A 1 41  ? 128.893 129.685 106.025 1.00 58.24  ? 41  GLN A NE2   1 
ATOM 173  N N     . ALA A 1 42  ? 122.119 127.204 106.505 1.00 52.57  ? 42  ALA A N     1 
ATOM 174  C CA    . ALA A 1 42  ? 121.140 126.133 106.472 1.00 42.55  ? 42  ALA A CA    1 
ATOM 175  C C     . ALA A 1 42  ? 121.407 125.203 105.293 1.00 42.49  ? 42  ALA A C     1 
ATOM 176  O O     . ALA A 1 42  ? 122.263 125.461 104.445 1.00 40.20  ? 42  ALA A O     1 
ATOM 177  C CB    . ALA A 1 42  ? 119.730 126.714 106.395 1.00 36.28  ? 42  ALA A CB    1 
ATOM 178  N N     . ASN A 1 43  ? 120.642 124.113 105.213 1.00 38.37  ? 43  ASN A N     1 
ATOM 179  C CA    . ASN A 1 43  ? 120.639 123.262 104.023 1.00 32.73  ? 43  ASN A CA    1 
ATOM 180  C C     . ASN A 1 43  ? 119.662 123.817 102.989 1.00 34.62  ? 43  ASN A C     1 
ATOM 181  O O     . ASN A 1 43  ? 118.666 123.197 102.628 1.00 40.17  ? 43  ASN A O     1 
ATOM 182  C CB    . ASN A 1 43  ? 120.285 121.826 104.375 1.00 27.27  ? 43  ASN A CB    1 
ATOM 183  C CG    . ASN A 1 43  ? 120.869 120.832 103.396 1.00 32.77  ? 43  ASN A CG    1 
ATOM 184  O OD1   . ASN A 1 43  ? 121.238 121.193 102.281 1.00 36.99  ? 43  ASN A OD1   1 
ATOM 185  N ND2   . ASN A 1 43  ? 120.952 119.575 103.804 1.00 32.59  ? 43  ASN A ND2   1 
ATOM 186  N N     . PHE A 1 44  ? 119.969 125.015 102.516 1.00 30.81  ? 44  PHE A N     1 
ATOM 187  C CA    . PHE A 1 44  ? 119.115 125.693 101.563 1.00 27.26  ? 44  PHE A CA    1 
ATOM 188  C C     . PHE A 1 44  ? 119.984 126.358 100.514 1.00 41.62  ? 44  PHE A C     1 
ATOM 189  O O     . PHE A 1 44  ? 121.157 126.652 100.760 1.00 51.99  ? 44  PHE A O     1 
ATOM 190  C CB    . PHE A 1 44  ? 118.220 126.731 102.229 1.00 32.96  ? 44  PHE A CB    1 
ATOM 191  C CG    . PHE A 1 44  ? 116.880 126.205 102.625 1.00 38.56  ? 44  PHE A CG    1 
ATOM 192  C CD1   . PHE A 1 44  ? 115.834 126.182 101.730 1.00 43.99  ? 44  PHE A CD1   1 
ATOM 193  C CD2   . PHE A 1 44  ? 116.657 125.758 103.905 1.00 37.32  ? 44  PHE A CD2   1 
ATOM 194  C CE1   . PHE A 1 44  ? 114.597 125.707 102.100 1.00 41.98  ? 44  PHE A CE1   1 
ATOM 195  C CE2   . PHE A 1 44  ? 115.421 125.291 104.272 1.00 24.60  ? 44  PHE A CE2   1 
ATOM 196  C CZ    . PHE A 1 44  ? 114.397 125.267 103.378 1.00 24.44  ? 44  PHE A CZ    1 
ATOM 197  N N     . PHE A 1 45  ? 119.405 126.581 99.340  1.00 40.79  ? 45  PHE A N     1 
ATOM 198  C CA    . PHE A 1 45  ? 120.123 127.158 98.213  1.00 41.49  ? 45  PHE A CA    1 
ATOM 199  C C     . PHE A 1 45  ? 119.262 128.241 97.592  1.00 41.88  ? 45  PHE A C     1 
ATOM 200  O O     . PHE A 1 45  ? 118.148 127.966 97.134  1.00 37.41  ? 45  PHE A O     1 
ATOM 201  C CB    . PHE A 1 45  ? 120.504 126.084 97.200  1.00 32.45  ? 45  PHE A CB    1 
ATOM 202  C CG    . PHE A 1 45  ? 121.454 125.077 97.750  1.00 36.66  ? 45  PHE A CG    1 
ATOM 203  C CD1   . PHE A 1 45  ? 122.807 125.337 97.745  1.00 46.61  ? 45  PHE A CD1   1 
ATOM 204  C CD2   . PHE A 1 45  ? 121.000 123.903 98.320  1.00 34.06  ? 45  PHE A CD2   1 
ATOM 205  C CE1   . PHE A 1 45  ? 123.697 124.436 98.267  1.00 47.59  ? 45  PHE A CE1   1 
ATOM 206  C CE2   . PHE A 1 45  ? 121.888 122.992 98.846  1.00 32.78  ? 45  PHE A CE2   1 
ATOM 207  C CZ    . PHE A 1 45  ? 123.239 123.264 98.816  1.00 36.15  ? 45  PHE A CZ    1 
ATOM 208  N N     . GLU A 1 46  ? 119.788 129.463 97.600  1.00 47.39  ? 46  GLU A N     1 
ATOM 209  C CA    . GLU A 1 46  ? 119.070 130.629 97.112  1.00 50.07  ? 46  GLU A CA    1 
ATOM 210  C C     . GLU A 1 46  ? 118.834 130.522 95.611  1.00 53.48  ? 46  GLU A C     1 
ATOM 211  O O     . GLU A 1 46  ? 119.631 129.940 94.873  1.00 48.99  ? 46  GLU A O     1 
ATOM 212  C CB    . GLU A 1 46  ? 119.864 131.894 97.439  1.00 45.04  ? 46  GLU A CB    1 
ATOM 213  C CG    . GLU A 1 46  ? 119.029 133.102 97.813  1.00 41.75  ? 46  GLU A CG    1 
ATOM 214  C CD    . GLU A 1 46  ? 119.845 134.163 98.523  1.00 44.22  ? 46  GLU A CD    1 
ATOM 215  O OE1   . GLU A 1 46  ? 120.826 134.655 97.928  1.00 49.94  ? 46  GLU A OE1   1 
ATOM 216  O OE2   . GLU A 1 46  ? 119.510 134.503 99.677  1.00 44.39  ? 46  GLU A OE2   1 
ATOM 217  N N     . MET A 1 47  ? 117.707 131.067 95.168  1.00 56.28  ? 47  MET A N     1 
ATOM 218  C CA    . MET A 1 47  ? 117.278 130.928 93.787  1.00 47.52  ? 47  MET A CA    1 
ATOM 219  C C     . MET A 1 47  ? 116.320 132.061 93.470  1.00 53.61  ? 47  MET A C     1 
ATOM 220  O O     . MET A 1 47  ? 115.569 132.499 94.341  1.00 62.87  ? 47  MET A O     1 
ATOM 221  C CB    . MET A 1 47  ? 116.675 129.525 93.565  1.00 50.22  ? 47  MET A CB    1 
ATOM 222  C CG    . MET A 1 47  ? 115.300 129.152 94.183  1.00 54.47  ? 47  MET A CG    1 
ATOM 223  S SD    . MET A 1 47  ? 113.732 129.906 93.700  1.00 57.06  ? 47  MET A SD    1 
ATOM 224  C CE    . MET A 1 47  ? 113.635 129.242 92.052  1.00 60.93  ? 47  MET A CE    1 
ATOM 225  N N     . ASP A 1 48  ? 116.364 132.549 92.238  1.00 53.84  ? 48  ASP A N     1 
ATOM 226  C CA    . ASP A 1 48  ? 115.474 133.618 91.804  1.00 55.99  ? 48  ASP A CA    1 
ATOM 227  C C     . ASP A 1 48  ? 114.357 132.990 90.982  1.00 55.18  ? 48  ASP A C     1 
ATOM 228  O O     . ASP A 1 48  ? 114.613 132.345 89.960  1.00 56.95  ? 48  ASP A O     1 
ATOM 229  C CB    . ASP A 1 48  ? 116.226 134.685 91.013  1.00 59.61  ? 48  ASP A CB    1 
ATOM 230  C CG    . ASP A 1 48  ? 115.512 136.024 91.017  1.00 60.48  ? 48  ASP A CG    1 
ATOM 231  O OD1   . ASP A 1 48  ? 114.904 136.370 92.052  1.00 55.66  ? 48  ASP A OD1   1 
ATOM 232  O OD2   . ASP A 1 48  ? 115.558 136.731 89.989  1.00 59.41  ? 48  ASP A OD2   1 
ATOM 233  N N     . ILE A 1 49  ? 113.125 133.163 91.443  1.00 51.96  ? 49  ILE A N     1 
ATOM 234  C CA    . ILE A 1 49  ? 111.953 132.596 90.786  1.00 53.39  ? 49  ILE A CA    1 
ATOM 235  C C     . ILE A 1 49  ? 111.222 133.727 90.065  1.00 53.97  ? 49  ILE A C     1 
ATOM 236  O O     . ILE A 1 49  ? 111.002 134.789 90.668  1.00 54.97  ? 49  ILE A O     1 
ATOM 237  C CB    . ILE A 1 49  ? 111.046 131.874 91.794  1.00 58.02  ? 49  ILE A CB    1 
ATOM 238  C CG1   . ILE A 1 49  ? 109.700 131.490 91.180  1.00 61.06  ? 49  ILE A CG1   1 
ATOM 239  C CG2   . ILE A 1 49  ? 110.915 132.644 93.119  1.00 52.52  ? 49  ILE A CG2   1 
ATOM 240  C CD1   . ILE A 1 49  ? 108.953 130.473 91.983  1.00 53.20  ? 49  ILE A CD1   1 
ATOM 241  N N     . PRO A 1 50  ? 110.873 133.568 88.786  1.00 64.12  ? 50  PRO A N     1 
ATOM 242  C CA    . PRO A 1 50  ? 110.231 134.667 88.057  1.00 67.09  ? 50  PRO A CA    1 
ATOM 243  C C     . PRO A 1 50  ? 108.753 134.803 88.377  1.00 69.33  ? 50  PRO A C     1 
ATOM 244  O O     . PRO A 1 50  ? 108.228 134.106 89.249  1.00 71.49  ? 50  PRO A O     1 
ATOM 245  C CB    . PRO A 1 50  ? 110.451 134.282 86.591  1.00 67.42  ? 50  PRO A CB    1 
ATOM 246  C CG    . PRO A 1 50  ? 110.482 132.795 86.615  1.00 66.82  ? 50  PRO A CG    1 
ATOM 247  C CD    . PRO A 1 50  ? 111.127 132.407 87.916  1.00 66.21  ? 50  PRO A CD    1 
ATOM 248  N N     . LYS A 1 51  ? 108.076 135.709 87.678  1.00 74.27  ? 51  LYS A N     1 
ATOM 249  C CA    . LYS A 1 51  ? 106.648 135.925 87.850  1.00 72.04  ? 51  LYS A CA    1 
ATOM 250  C C     . LYS A 1 51  ? 105.824 135.281 86.745  1.00 70.44  ? 51  LYS A C     1 
ATOM 251  O O     . LYS A 1 51  ? 104.635 135.588 86.615  1.00 69.96  ? 51  LYS A O     1 
ATOM 252  C CB    . LYS A 1 51  ? 106.344 137.423 87.924  1.00 74.57  ? 51  LYS A CB    1 
ATOM 253  C CG    . LYS A 1 51  ? 106.227 137.964 89.340  1.00 71.94  ? 51  LYS A CG    1 
ATOM 254  C CD    . LYS A 1 51  ? 107.587 138.318 89.911  1.00 75.95  ? 51  LYS A CD    1 
ATOM 255  C CE    . LYS A 1 51  ? 107.560 138.331 91.429  1.00 75.28  ? 51  LYS A CE    1 
ATOM 256  N NZ    . LYS A 1 51  ? 108.868 137.913 92.006  1.00 75.71  ? 51  LYS A NZ    1 
ATOM 257  N N     . ILE A 1 52  ? 106.430 134.402 85.943  1.00 72.66  ? 52  ILE A N     1 
ATOM 258  C CA    . ILE A 1 52  ? 105.696 133.773 84.855  1.00 75.18  ? 52  ILE A CA    1 
ATOM 259  C C     . ILE A 1 52  ? 104.762 132.707 85.415  1.00 70.56  ? 52  ILE A C     1 
ATOM 260  O O     . ILE A 1 52  ? 104.905 132.255 86.556  1.00 70.44  ? 52  ILE A O     1 
ATOM 261  C CB    . ILE A 1 52  ? 106.655 133.175 83.811  1.00 77.13  ? 52  ILE A CB    1 
ATOM 262  C CG1   . ILE A 1 52  ? 107.302 131.889 84.346  1.00 72.44  ? 52  ILE A CG1   1 
ATOM 263  C CG2   . ILE A 1 52  ? 107.686 134.224 83.394  1.00 76.59  ? 52  ILE A CG2   1 
ATOM 264  C CD1   . ILE A 1 52  ? 108.553 131.441 83.615  1.00 71.70  ? 52  ILE A CD1   1 
ATOM 265  N N     . ASP A 1 53  ? 103.787 132.310 84.609  1.00 79.00  ? 53  ASP A N     1 
ATOM 266  C CA    . ASP A 1 53  ? 102.772 131.355 85.028  1.00 80.33  ? 53  ASP A CA    1 
ATOM 267  C C     . ASP A 1 53  ? 103.044 130.009 84.368  1.00 80.30  ? 53  ASP A C     1 
ATOM 268  O O     . ASP A 1 53  ? 103.218 129.932 83.147  1.00 80.02  ? 53  ASP A O     1 
ATOM 269  C CB    . ASP A 1 53  ? 101.375 131.862 84.676  1.00 79.28  ? 53  ASP A CB    1 
ATOM 270  C CG    . ASP A 1 53  ? 101.075 133.208 85.299  1.00 77.38  ? 53  ASP A CG    1 
ATOM 271  O OD1   . ASP A 1 53  ? 100.881 133.267 86.531  1.00 77.82  ? 53  ASP A OD1   1 
ATOM 272  O OD2   . ASP A 1 53  ? 101.042 134.210 84.556  1.00 76.71  ? 53  ASP A OD2   1 
ATOM 273  N N     . ILE A 1 54  ? 103.080 128.958 85.179  1.00 84.34  ? 54  ILE A N     1 
ATOM 274  C CA    . ILE A 1 54  ? 103.329 127.609 84.688  1.00 85.00  ? 54  ILE A CA    1 
ATOM 275  C C     . ILE A 1 54  ? 101.990 126.970 84.341  1.00 87.21  ? 54  ILE A C     1 
ATOM 276  O O     . ILE A 1 54  ? 101.065 126.961 85.157  1.00 86.78  ? 54  ILE A O     1 
ATOM 277  C CB    . ILE A 1 54  ? 104.093 126.780 85.730  1.00 83.77  ? 54  ILE A CB    1 
ATOM 278  C CG1   . ILE A 1 54  ? 105.460 127.405 86.002  1.00 83.17  ? 54  ILE A CG1   1 
ATOM 279  C CG2   . ILE A 1 54  ? 104.270 125.355 85.257  1.00 86.89  ? 54  ILE A CG2   1 
ATOM 280  C CD1   . ILE A 1 54  ? 106.244 126.696 87.077  1.00 83.65  ? 54  ILE A CD1   1 
ATOM 281  N N     . TYR A 1 55  ? 101.873 126.459 83.122  1.00 99.26  ? 55  TYR A N     1 
ATOM 282  C CA    . TYR A 1 55  ? 100.635 125.835 82.677  1.00 99.91  ? 55  TYR A CA    1 
ATOM 283  C C     . TYR A 1 55  ? 100.555 124.396 83.167  1.00 99.50  ? 55  TYR A C     1 
ATOM 284  O O     . TYR A 1 55  ? 101.558 123.808 83.570  1.00 98.07  ? 55  TYR A O     1 
ATOM 285  C CB    . TYR A 1 55  ? 100.520 125.898 81.153  1.00 98.88  ? 55  TYR A CB    1 
ATOM 286  C CG    . TYR A 1 55  ? 100.419 127.311 80.606  1.00 98.78  ? 55  TYR A CG    1 
ATOM 287  C CD1   . TYR A 1 55  ? 101.559 128.075 80.356  1.00 97.13  ? 55  TYR A CD1   1 
ATOM 288  C CD2   . TYR A 1 55  ? 99.178  127.876 80.328  1.00 99.34  ? 55  TYR A CD2   1 
ATOM 289  C CE1   . TYR A 1 55  ? 101.463 129.366 79.870  1.00 98.59  ? 55  TYR A CE1   1 
ATOM 290  C CE2   . TYR A 1 55  ? 99.073  129.164 79.826  1.00 99.68  ? 55  TYR A CE2   1 
ATOM 291  C CZ    . TYR A 1 55  ? 100.220 129.902 79.598  1.00 100.10 ? 55  TYR A CZ    1 
ATOM 292  O OH    . TYR A 1 55  ? 100.123 131.184 79.102  1.00 100.01 ? 55  TYR A OH    1 
ATOM 293  N N     . HIS A 1 56  ? 99.344  123.847 83.168  1.00 99.26  ? 56  HIS A N     1 
ATOM 294  C CA    . HIS A 1 56  ? 99.080  122.486 83.615  1.00 96.95  ? 56  HIS A CA    1 
ATOM 295  C C     . HIS A 1 56  ? 98.330  121.703 82.551  1.00 99.64  ? 56  HIS A C     1 
ATOM 296  O O     . HIS A 1 56  ? 97.320  122.170 82.013  1.00 100.35 ? 56  HIS A O     1 
ATOM 297  C CB    . HIS A 1 56  ? 98.329  122.502 84.957  1.00 94.56  ? 56  HIS A CB    1 
ATOM 298  C CG    . HIS A 1 56  ? 97.902  121.152 85.448  1.00 93.72  ? 56  HIS A CG    1 
ATOM 299  N ND1   . HIS A 1 56  ? 98.623  120.000 85.221  1.00 94.81  ? 56  HIS A ND1   1 
ATOM 300  C CD2   . HIS A 1 56  ? 96.885  120.796 86.267  1.00 95.86  ? 56  HIS A CD2   1 
ATOM 301  C CE1   . HIS A 1 56  ? 98.028  118.982 85.815  1.00 97.80  ? 56  HIS A CE1   1 
ATOM 302  N NE2   . HIS A 1 56  ? 96.969  119.439 86.456  1.00 97.94  ? 56  HIS A NE2   1 
ATOM 303  N N     . TYR A 1 57  ? 98.841  120.511 82.259  1.00 104.41 ? 57  TYR A N     1 
ATOM 304  C CA    . TYR A 1 57  ? 98.242  119.575 81.329  1.00 103.42 ? 57  TYR A CA    1 
ATOM 305  C C     . TYR A 1 57  ? 98.125  118.225 82.022  1.00 102.90 ? 57  TYR A C     1 
ATOM 306  O O     . TYR A 1 57  ? 98.869  117.923 82.958  1.00 103.35 ? 57  TYR A O     1 
ATOM 307  C CB    . TYR A 1 57  ? 99.086  119.437 80.059  1.00 107.19 ? 57  TYR A CB    1 
ATOM 308  C CG    . TYR A 1 57  ? 99.290  120.732 79.308  1.00 108.50 ? 57  TYR A CG    1 
ATOM 309  C CD1   . TYR A 1 57  ? 98.364  121.166 78.371  1.00 107.02 ? 57  TYR A CD1   1 
ATOM 310  C CD2   . TYR A 1 57  ? 100.407 121.530 79.552  1.00 104.18 ? 57  TYR A CD2   1 
ATOM 311  C CE1   . TYR A 1 57  ? 98.551  122.347 77.684  1.00 108.29 ? 57  TYR A CE1   1 
ATOM 312  C CE2   . TYR A 1 57  ? 100.601 122.717 78.875  1.00 100.86 ? 57  TYR A CE2   1 
ATOM 313  C CZ    . TYR A 1 57  ? 99.668  123.120 77.943  1.00 106.17 ? 57  TYR A CZ    1 
ATOM 314  O OH    . TYR A 1 57  ? 99.852  124.301 77.263  1.00 107.73 ? 57  TYR A OH    1 
ATOM 315  N N     . GLU A 1 58  ? 97.187  117.408 81.557  1.00 103.37 ? 58  GLU A N     1 
ATOM 316  C CA    . GLU A 1 58  ? 96.991  116.073 82.103  1.00 103.73 ? 58  GLU A CA    1 
ATOM 317  C C     . GLU A 1 58  ? 97.375  115.018 81.073  1.00 105.37 ? 58  GLU A C     1 
ATOM 318  O O     . GLU A 1 58  ? 97.186  115.204 79.868  1.00 104.56 ? 58  GLU A O     1 
ATOM 319  C CB    . GLU A 1 58  ? 95.538  115.861 82.534  1.00 105.54 ? 58  GLU A CB    1 
ATOM 320  C CG    . GLU A 1 58  ? 95.333  114.736 83.537  1.00 103.67 ? 58  GLU A CG    1 
ATOM 321  C CD    . GLU A 1 58  ? 93.966  114.094 83.413  1.00 102.72 ? 58  GLU A CD    1 
ATOM 322  O OE1   . GLU A 1 58  ? 93.605  113.285 84.292  1.00 99.51  ? 58  GLU A OE1   1 
ATOM 323  O OE2   . GLU A 1 58  ? 93.255  114.394 82.431  1.00 106.30 ? 58  GLU A OE2   1 
ATOM 324  N N     . LEU A 1 59  ? 97.917  113.903 81.558  1.00 111.00 ? 59  LEU A N     1 
ATOM 325  C CA    . LEU A 1 59  ? 98.193  112.742 80.716  1.00 112.07 ? 59  LEU A CA    1 
ATOM 326  C C     . LEU A 1 59  ? 97.276  111.599 81.133  1.00 112.79 ? 59  LEU A C     1 
ATOM 327  O O     . LEU A 1 59  ? 97.422  111.041 82.224  1.00 112.40 ? 59  LEU A O     1 
ATOM 328  C CB    . LEU A 1 59  ? 99.649  112.301 80.802  1.00 111.17 ? 59  LEU A CB    1 
ATOM 329  C CG    . LEU A 1 59  ? 100.747 113.183 80.223  1.00 108.93 ? 59  LEU A CG    1 
ATOM 330  C CD1   . LEU A 1 59  ? 101.923 112.296 79.917  1.00 108.34 ? 59  LEU A CD1   1 
ATOM 331  C CD2   . LEU A 1 59  ? 100.302 113.930 78.999  1.00 110.01 ? 59  LEU A CD2   1 
ATOM 332  N N     . ASP A 1 60  ? 96.338  111.246 80.265  1.00 121.11 ? 60  ASP A N     1 
ATOM 333  C CA    . ASP A 1 60  ? 95.565  110.025 80.433  1.00 121.48 ? 60  ASP A CA    1 
ATOM 334  C C     . ASP A 1 60  ? 96.233  108.933 79.607  1.00 122.22 ? 60  ASP A C     1 
ATOM 335  O O     . ASP A 1 60  ? 96.053  108.874 78.387  1.00 122.92 ? 60  ASP A O     1 
ATOM 336  C CB    . ASP A 1 60  ? 94.114  110.239 80.008  1.00 121.25 ? 60  ASP A CB    1 
ATOM 337  C CG    . ASP A 1 60  ? 93.189  109.154 80.516  1.00 121.35 ? 60  ASP A CG    1 
ATOM 338  O OD1   . ASP A 1 60  ? 93.225  108.030 79.972  1.00 123.62 ? 60  ASP A OD1   1 
ATOM 339  O OD2   . ASP A 1 60  ? 92.415  109.428 81.457  1.00 120.94 ? 60  ASP A OD2   1 
ATOM 340  N N     . ILE A 1 61  ? 97.006  108.074 80.271  1.00 120.53 ? 61  ILE A N     1 
ATOM 341  C CA    . ILE A 1 61  ? 97.809  107.054 79.608  1.00 120.24 ? 61  ILE A CA    1 
ATOM 342  C C     . ILE A 1 61  ? 96.988  105.774 79.540  1.00 120.95 ? 61  ILE A C     1 
ATOM 343  O O     . ILE A 1 61  ? 96.486  105.298 80.564  1.00 120.42 ? 61  ILE A O     1 
ATOM 344  C CB    . ILE A 1 61  ? 99.142  106.801 80.341  1.00 118.29 ? 61  ILE A CB    1 
ATOM 345  C CG1   . ILE A 1 61  ? 99.941  108.093 80.502  1.00 116.97 ? 61  ILE A CG1   1 
ATOM 346  C CG2   . ILE A 1 61  ? 99.982  105.771 79.600  1.00 116.88 ? 61  ILE A CG2   1 
ATOM 347  C CD1   . ILE A 1 61  ? 100.466 108.309 81.900  1.00 117.66 ? 61  ILE A CD1   1 
ATOM 348  N N     . LYS A 1 62  ? 96.845  105.226 78.333  1.00 124.53 ? 62  LYS A N     1 
ATOM 349  C CA    . LYS A 1 62  ? 96.247  103.919 78.155  1.00 124.26 ? 62  LYS A CA    1 
ATOM 350  C C     . LYS A 1 62  ? 97.264  103.084 77.383  1.00 122.96 ? 62  LYS A C     1 
ATOM 351  O O     . LYS A 1 62  ? 97.673  103.482 76.276  1.00 120.74 ? 62  LYS A O     1 
ATOM 352  C CB    . LYS A 1 62  ? 94.910  103.968 77.412  1.00 123.96 ? 62  LYS A CB    1 
ATOM 353  C CG    . LYS A 1 62  ? 93.941  102.866 77.822  1.00 123.61 ? 62  LYS A CG    1 
ATOM 354  C CD    . LYS A 1 62  ? 94.063  101.643 76.922  1.00 123.09 ? 62  LYS A CD    1 
ATOM 355  C CE    . LYS A 1 62  ? 93.270  100.467 77.467  1.00 123.52 ? 62  LYS A CE    1 
ATOM 356  N NZ    . LYS A 1 62  ? 93.535  99.219  76.700  1.00 123.95 ? 62  LYS A NZ    1 
ATOM 357  N N     . PRO A 1 63  ? 97.695  101.935 77.922  1.00 123.03 ? 63  PRO A N     1 
ATOM 358  C CA    . PRO A 1 63  ? 97.339  101.344 79.222  1.00 122.95 ? 63  PRO A CA    1 
ATOM 359  C C     . PRO A 1 63  ? 98.154  101.896 80.395  1.00 122.68 ? 63  PRO A C     1 
ATOM 360  O O     . PRO A 1 63  ? 99.222  102.472 80.206  1.00 122.99 ? 63  PRO A O     1 
ATOM 361  C CB    . PRO A 1 63  ? 97.622  99.856  78.996  1.00 123.22 ? 63  PRO A CB    1 
ATOM 362  C CG    . PRO A 1 63  ? 98.793  99.861  78.061  1.00 123.84 ? 63  PRO A CG    1 
ATOM 363  C CD    . PRO A 1 63  ? 98.565  101.037 77.141  1.00 123.37 ? 63  PRO A CD    1 
ATOM 364  N N     . GLU A 1 64  ? 97.661  101.725 81.620  1.00 121.12 ? 64  GLU A N     1 
ATOM 365  C CA    . GLU A 1 64  ? 98.376  102.115 82.828  1.00 121.05 ? 64  GLU A CA    1 
ATOM 366  C C     . GLU A 1 64  ? 99.190  100.963 83.415  1.00 123.07 ? 64  GLU A C     1 
ATOM 367  O O     . GLU A 1 64  ? 99.714  101.085 84.528  1.00 121.63 ? 64  GLU A O     1 
ATOM 368  C CB    . GLU A 1 64  ? 97.381  102.666 83.868  1.00 120.77 ? 64  GLU A CB    1 
ATOM 369  C CG    . GLU A 1 64  ? 97.926  103.725 84.855  1.00 121.96 ? 64  GLU A CG    1 
ATOM 370  C CD    . GLU A 1 64  ? 97.872  105.154 84.339  1.00 123.11 ? 64  GLU A CD    1 
ATOM 371  O OE1   . GLU A 1 64  ? 97.687  106.069 85.168  1.00 122.82 ? 64  GLU A OE1   1 
ATOM 372  O OE2   . GLU A 1 64  ? 98.008  105.372 83.121  1.00 123.57 ? 64  GLU A OE2   1 
ATOM 373  N N     . LYS A 1 65  ? 99.315  99.846  82.692  1.00 126.56 ? 65  LYS A N     1 
ATOM 374  C CA    . LYS A 1 65  ? 100.114 98.732  83.193  1.00 125.73 ? 65  LYS A CA    1 
ATOM 375  C C     . LYS A 1 65  ? 101.607 99.037  83.131  1.00 126.95 ? 65  LYS A C     1 
ATOM 376  O O     . LYS A 1 65  ? 102.394 98.432  83.869  1.00 129.43 ? 65  LYS A O     1 
ATOM 377  C CB    . LYS A 1 65  ? 99.766  97.451  82.422  1.00 122.71 ? 65  LYS A CB    1 
ATOM 378  C CG    . LYS A 1 65  ? 99.866  97.509  80.885  1.00 124.81 ? 65  LYS A CG    1 
ATOM 379  C CD    . LYS A 1 65  ? 101.223 97.059  80.330  1.00 124.98 ? 65  LYS A CD    1 
ATOM 380  C CE    . LYS A 1 65  ? 101.269 97.164  78.816  1.00 123.94 ? 65  LYS A CE    1 
ATOM 381  N NZ    . LYS A 1 65  ? 102.557 96.665  78.264  1.00 123.00 ? 65  LYS A NZ    1 
ATOM 382  N N     . CYS A 1 66  ? 102.013 99.956  82.263  1.00 116.75 ? 66  CYS A N     1 
ATOM 383  C CA    . CYS A 1 66  ? 103.417 100.318 82.164  1.00 115.98 ? 66  CYS A CA    1 
ATOM 384  C C     . CYS A 1 66  ? 103.825 101.184 83.353  1.00 114.20 ? 66  CYS A C     1 
ATOM 385  O O     . CYS A 1 66  ? 103.018 101.993 83.831  1.00 111.28 ? 66  CYS A O     1 
ATOM 386  C CB    . CYS A 1 66  ? 103.681 101.057 80.854  1.00 116.60 ? 66  CYS A CB    1 
ATOM 387  S SG    . CYS A 1 66  ? 102.552 102.425 80.530  1.00 116.97 ? 66  CYS A SG    1 
ATOM 388  N N     . PRO A 1 67  ? 105.055 101.041 83.866  1.00 110.81 ? 67  PRO A N     1 
ATOM 389  C CA    . PRO A 1 67  ? 105.506 101.896 84.974  1.00 112.14 ? 67  PRO A CA    1 
ATOM 390  C C     . PRO A 1 67  ? 105.827 103.332 84.572  1.00 114.76 ? 67  PRO A C     1 
ATOM 391  O O     . PRO A 1 67  ? 105.586 103.753 83.435  1.00 115.05 ? 67  PRO A O     1 
ATOM 392  C CB    . PRO A 1 67  ? 106.761 101.173 85.484  1.00 112.32 ? 67  PRO A CB    1 
ATOM 393  C CG    . PRO A 1 67  ? 106.610 99.769  85.023  1.00 111.64 ? 67  PRO A CG    1 
ATOM 394  C CD    . PRO A 1 67  ? 105.921 99.862  83.701  1.00 111.45 ? 67  PRO A CD    1 
ATOM 395  N N     . ARG A 1 68  ? 106.375 104.086 85.531  1.00 103.51 ? 68  ARG A N     1 
ATOM 396  C CA    . ARG A 1 68  ? 106.573 105.524 85.362  1.00 102.99 ? 68  ARG A CA    1 
ATOM 397  C C     . ARG A 1 68  ? 107.696 105.821 84.371  1.00 102.70 ? 68  ARG A C     1 
ATOM 398  O O     . ARG A 1 68  ? 107.609 106.771 83.581  1.00 101.10 ? 68  ARG A O     1 
ATOM 399  C CB    . ARG A 1 68  ? 106.853 106.153 86.734  1.00 102.13 ? 68  ARG A CB    1 
ATOM 400  C CG    . ARG A 1 68  ? 107.330 107.597 86.724  1.00 100.86 ? 68  ARG A CG    1 
ATOM 401  C CD    . ARG A 1 68  ? 107.737 108.099 88.110  1.00 98.95  ? 68  ARG A CD    1 
ATOM 402  N NE    . ARG A 1 68  ? 106.667 108.059 89.098  1.00 98.93  ? 68  ARG A NE    1 
ATOM 403  C CZ    . ARG A 1 68  ? 106.837 108.336 90.384  1.00 100.51 ? 68  ARG A CZ    1 
ATOM 404  N NH1   . ARG A 1 68  ? 108.019 108.685 90.864  1.00 102.56 ? 68  ARG A NH1   1 
ATOM 405  N NH2   . ARG A 1 68  ? 105.798 108.260 91.210  1.00 98.87  ? 68  ARG A NH2   1 
ATOM 406  N N     . ARG A 1 69  ? 108.753 105.001 84.388  1.00 107.21 ? 69  ARG A N     1 
ATOM 407  C CA    . ARG A 1 69  ? 109.889 105.204 83.490  1.00 104.89 ? 69  ARG A CA    1 
ATOM 408  C C     . ARG A 1 69  ? 109.502 104.960 82.038  1.00 103.80 ? 69  ARG A C     1 
ATOM 409  O O     . ARG A 1 69  ? 109.998 105.643 81.133  1.00 107.10 ? 69  ARG A O     1 
ATOM 410  C CB    . ARG A 1 69  ? 111.047 104.293 83.912  1.00 105.94 ? 69  ARG A CB    1 
ATOM 411  C CG    . ARG A 1 69  ? 112.422 104.617 83.310  1.00 105.94 ? 69  ARG A CG    1 
ATOM 412  C CD    . ARG A 1 69  ? 112.746 103.741 82.089  1.00 108.13 ? 69  ARG A CD    1 
ATOM 413  N NE    . ARG A 1 69  ? 114.097 103.930 81.570  1.00 106.20 ? 69  ARG A NE    1 
ATOM 414  C CZ    . ARG A 1 69  ? 114.505 104.976 80.865  1.00 105.20 ? 69  ARG A CZ    1 
ATOM 415  N NH1   . ARG A 1 69  ? 113.673 105.939 80.505  1.00 106.24 ? 69  ARG A NH1   1 
ATOM 416  N NH2   . ARG A 1 69  ? 115.779 105.046 80.488  1.00 105.90 ? 69  ARG A NH2   1 
ATOM 417  N N     . VAL A 1 70  ? 108.610 103.995 81.800  1.00 98.23  ? 70  VAL A N     1 
ATOM 418  C CA    . VAL A 1 70  ? 108.110 103.748 80.451  1.00 102.07 ? 70  VAL A CA    1 
ATOM 419  C C     . VAL A 1 70  ? 107.266 104.924 79.977  1.00 103.11 ? 70  VAL A C     1 
ATOM 420  O O     . VAL A 1 70  ? 107.327 105.314 78.805  1.00 102.67 ? 70  VAL A O     1 
ATOM 421  C CB    . VAL A 1 70  ? 107.333 102.418 80.410  1.00 101.83 ? 70  VAL A CB    1 
ATOM 422  C CG1   . VAL A 1 70  ? 107.002 102.024 78.977  1.00 102.79 ? 70  VAL A CG1   1 
ATOM 423  C CG2   . VAL A 1 70  ? 108.143 101.324 81.083  1.00 101.69 ? 70  VAL A CG2   1 
ATOM 424  N N     . ASN A 1 71  ? 106.508 105.538 80.893  1.00 96.47  ? 71  ASN A N     1 
ATOM 425  C CA    . ASN A 1 71  ? 105.770 106.756 80.568  1.00 98.27  ? 71  ASN A CA    1 
ATOM 426  C C     . ASN A 1 71  ? 106.707 107.904 80.214  1.00 101.16 ? 71  ASN A C     1 
ATOM 427  O O     . ASN A 1 71  ? 106.454 108.633 79.251  1.00 100.10 ? 71  ASN A O     1 
ATOM 428  C CB    . ASN A 1 71  ? 104.863 107.151 81.733  1.00 97.71  ? 71  ASN A CB    1 
ATOM 429  C CG    . ASN A 1 71  ? 103.605 106.314 81.804  1.00 95.68  ? 71  ASN A CG    1 
ATOM 430  O OD1   . ASN A 1 71  ? 103.150 105.770 80.799  1.00 94.70  ? 71  ASN A OD1   1 
ATOM 431  N ND2   . ASN A 1 71  ? 103.036 106.202 82.999  1.00 97.08  ? 71  ASN A ND2   1 
ATOM 432  N N     . ARG A 1 72  ? 107.806 108.058 80.961  1.00 103.14 ? 72  ARG A N     1 
ATOM 433  C CA    . ARG A 1 72  ? 108.775 109.113 80.662  1.00 100.87 ? 72  ARG A CA    1 
ATOM 434  C C     . ARG A 1 72  ? 109.457 108.882 79.319  1.00 102.19 ? 72  ARG A C     1 
ATOM 435  O O     . ARG A 1 72  ? 109.681 109.833 78.556  1.00 101.32 ? 72  ARG A O     1 
ATOM 436  C CB    . ARG A 1 72  ? 109.813 109.205 81.778  1.00 99.78  ? 72  ARG A CB    1 
ATOM 437  C CG    . ARG A 1 72  ? 109.239 109.694 83.086  1.00 99.78  ? 72  ARG A CG    1 
ATOM 438  C CD    . ARG A 1 72  ? 110.086 110.797 83.696  1.00 100.26 ? 72  ARG A CD    1 
ATOM 439  N NE    . ARG A 1 72  ? 109.490 111.362 84.902  1.00 98.76  ? 72  ARG A NE    1 
ATOM 440  C CZ    . ARG A 1 72  ? 109.549 110.807 86.104  1.00 100.04 ? 72  ARG A CZ    1 
ATOM 441  N NH1   . ARG A 1 72  ? 110.123 109.631 86.297  1.00 99.60  ? 72  ARG A NH1   1 
ATOM 442  N NH2   . ARG A 1 72  ? 109.021 111.449 87.142  1.00 99.10  ? 72  ARG A NH2   1 
ATOM 443  N N     . GLU A 1 73  ? 109.747 107.617 78.997  1.00 109.84 ? 73  GLU A N     1 
ATOM 444  C CA    . GLU A 1 73  ? 110.345 107.293 77.707  1.00 109.35 ? 73  GLU A CA    1 
ATOM 445  C C     . GLU A 1 73  ? 109.378 107.542 76.557  1.00 111.25 ? 73  GLU A C     1 
ATOM 446  O O     . GLU A 1 73  ? 109.793 108.014 75.493  1.00 116.46 ? 73  GLU A O     1 
ATOM 447  C CB    . GLU A 1 73  ? 110.824 105.841 77.690  1.00 108.76 ? 73  GLU A CB    1 
ATOM 448  C CG    . GLU A 1 73  ? 111.523 105.309 76.398  1.00 112.28 ? 73  GLU A CG    1 
ATOM 449  C CD    . GLU A 1 73  ? 112.828 105.997 75.919  1.00 112.56 ? 73  GLU A CD    1 
ATOM 450  O OE1   . GLU A 1 73  ? 113.540 105.331 75.140  1.00 111.17 ? 73  GLU A OE1   1 
ATOM 451  O OE2   . GLU A 1 73  ? 113.190 107.135 76.291  1.00 112.35 ? 73  GLU A OE2   1 
ATOM 452  N N     . ILE A 1 74  ? 108.083 107.260 76.747  1.00 103.75 ? 74  ILE A N     1 
ATOM 453  C CA    . ILE A 1 74  ? 107.148 107.527 75.653  1.00 108.51 ? 74  ILE A CA    1 
ATOM 454  C C     . ILE A 1 74  ? 106.886 109.021 75.476  1.00 110.04 ? 74  ILE A C     1 
ATOM 455  O O     . ILE A 1 74  ? 106.721 109.470 74.338  1.00 110.88 ? 74  ILE A O     1 
ATOM 456  C CB    . ILE A 1 74  ? 105.854 106.675 75.773  1.00 109.22 ? 74  ILE A CB    1 
ATOM 457  C CG1   . ILE A 1 74  ? 104.818 107.149 76.824  1.00 106.01 ? 74  ILE A CG1   1 
ATOM 458  C CG2   . ILE A 1 74  ? 106.176 105.187 75.796  1.00 111.20 ? 74  ILE A CG2   1 
ATOM 459  C CD1   . ILE A 1 74  ? 103.697 108.101 76.336  1.00 106.47 ? 74  ILE A CD1   1 
ATOM 460  N N     . VAL A 1 75  ? 106.867 109.818 76.558  1.00 105.94 ? 75  VAL A N     1 
ATOM 461  C CA    . VAL A 1 75  ? 106.740 111.273 76.392  1.00 103.00 ? 75  VAL A CA    1 
ATOM 462  C C     . VAL A 1 75  ? 107.981 111.850 75.719  1.00 103.52 ? 75  VAL A C     1 
ATOM 463  O O     . VAL A 1 75  ? 107.874 112.724 74.850  1.00 105.53 ? 75  VAL A O     1 
ATOM 464  C CB    . VAL A 1 75  ? 106.428 111.976 77.728  1.00 104.51 ? 75  VAL A CB    1 
ATOM 465  C CG1   . VAL A 1 75  ? 106.115 113.441 77.497  1.00 103.80 ? 75  VAL A CG1   1 
ATOM 466  C CG2   . VAL A 1 75  ? 105.175 111.414 78.322  1.00 106.92 ? 75  VAL A CG2   1 
ATOM 467  N N     . GLU A 1 76  ? 109.169 111.326 76.059  1.00 110.00 ? 76  GLU A N     1 
ATOM 468  C CA    . GLU A 1 76  ? 110.387 111.700 75.337  1.00 110.73 ? 76  GLU A CA    1 
ATOM 469  C C     . GLU A 1 76  ? 110.315 111.293 73.867  1.00 111.36 ? 76  GLU A C     1 
ATOM 470  O O     . GLU A 1 76  ? 110.802 112.017 72.990  1.00 113.08 ? 76  GLU A O     1 
ATOM 471  C CB    . GLU A 1 76  ? 111.610 111.064 75.999  1.00 109.19 ? 76  GLU A CB    1 
ATOM 472  C CG    . GLU A 1 76  ? 112.938 111.673 75.573  1.00 109.55 ? 76  GLU A CG    1 
ATOM 473  C CD    . GLU A 1 76  ? 114.029 111.488 76.609  1.00 111.16 ? 76  GLU A CD    1 
ATOM 474  O OE1   . GLU A 1 76  ? 113.735 110.939 77.691  1.00 110.91 ? 76  GLU A OE1   1 
ATOM 475  O OE2   . GLU A 1 76  ? 115.181 111.889 76.342  1.00 112.30 ? 76  GLU A OE2   1 
ATOM 476  N N     . HIS A 1 77  ? 109.652 110.170 73.582  1.00 119.63 ? 77  HIS A N     1 
ATOM 477  C CA    . HIS A 1 77  ? 109.475 109.730 72.204  1.00 122.18 ? 77  HIS A CA    1 
ATOM 478  C C     . HIS A 1 77  ? 108.528 110.644 71.431  1.00 123.54 ? 77  HIS A C     1 
ATOM 479  O O     . HIS A 1 77  ? 108.709 110.846 70.227  1.00 123.84 ? 77  HIS A O     1 
ATOM 480  C CB    . HIS A 1 77  ? 108.972 108.287 72.165  1.00 121.89 ? 77  HIS A CB    1 
ATOM 481  C CG    . HIS A 1 77  ? 109.226 107.597 70.860  1.00 124.93 ? 77  HIS A CG    1 
ATOM 482  N ND1   . HIS A 1 77  ? 108.221 107.312 69.961  1.00 124.16 ? 77  HIS A ND1   1 
ATOM 483  C CD2   . HIS A 1 77  ? 110.371 107.139 70.300  1.00 125.11 ? 77  HIS A CD2   1 
ATOM 484  C CE1   . HIS A 1 77  ? 108.735 106.706 68.905  1.00 123.33 ? 77  HIS A CE1   1 
ATOM 485  N NE2   . HIS A 1 77  ? 110.038 106.590 69.086  1.00 123.30 ? 77  HIS A NE2   1 
ATOM 486  N N     . MET A 1 78  ? 107.500 111.199 72.088  1.00 118.16 ? 78  MET A N     1 
ATOM 487  C CA    . MET A 1 78  ? 106.594 112.029 71.289  1.00 118.58 ? 78  MET A CA    1 
ATOM 488  C C     . MET A 1 78  ? 107.049 113.486 71.241  1.00 115.56 ? 78  MET A C     1 
ATOM 489  O O     . MET A 1 78  ? 106.577 114.242 70.385  1.00 115.40 ? 78  MET A O     1 
ATOM 490  C CB    . MET A 1 78  ? 105.128 111.923 71.750  1.00 118.38 ? 78  MET A CB    1 
ATOM 491  C CG    . MET A 1 78  ? 104.831 111.743 73.215  1.00 115.40 ? 78  MET A CG    1 
ATOM 492  S SD    . MET A 1 78  ? 103.169 112.224 73.740  1.00 114.66 ? 78  MET A SD    1 
ATOM 493  C CE    . MET A 1 78  ? 103.103 113.950 73.332  1.00 115.88 ? 78  MET A CE    1 
ATOM 494  N N     . VAL A 1 79  ? 107.972 113.905 72.114  1.00 115.45 ? 79  VAL A N     1 
ATOM 495  C CA    . VAL A 1 79  ? 108.689 115.149 71.817  1.00 116.51 ? 79  VAL A CA    1 
ATOM 496  C C     . VAL A 1 79  ? 109.693 114.934 70.688  1.00 116.25 ? 79  VAL A C     1 
ATOM 497  O O     . VAL A 1 79  ? 109.790 115.753 69.769  1.00 118.61 ? 79  VAL A O     1 
ATOM 498  C CB    . VAL A 1 79  ? 109.354 115.766 73.065  1.00 116.43 ? 79  VAL A CB    1 
ATOM 499  C CG1   . VAL A 1 79  ? 109.711 117.207 72.782  1.00 117.52 ? 79  VAL A CG1   1 
ATOM 500  C CG2   . VAL A 1 79  ? 108.390 115.821 74.213  1.00 114.14 ? 79  VAL A CG2   1 
ATOM 501  N N     . GLN A 1 80  ? 110.427 113.817 70.706  1.00 117.07 ? 80  GLN A N     1 
ATOM 502  C CA    . GLN A 1 80  ? 111.394 113.566 69.642  1.00 119.16 ? 80  GLN A CA    1 
ATOM 503  C C     . GLN A 1 80  ? 110.757 113.092 68.339  1.00 120.82 ? 80  GLN A C     1 
ATOM 504  O O     . GLN A 1 80  ? 111.468 112.954 67.338  1.00 121.06 ? 80  GLN A O     1 
ATOM 505  C CB    . GLN A 1 80  ? 112.436 112.541 70.096  1.00 117.86 ? 80  GLN A CB    1 
ATOM 506  C CG    . GLN A 1 80  ? 113.455 113.092 71.075  1.00 117.67 ? 80  GLN A CG    1 
ATOM 507  C CD    . GLN A 1 80  ? 114.230 112.003 71.784  1.00 119.13 ? 80  GLN A CD    1 
ATOM 508  O OE1   . GLN A 1 80  ? 113.668 110.979 72.175  1.00 122.92 ? 80  GLN A OE1   1 
ATOM 509  N NE2   . GLN A 1 80  ? 115.531 112.213 71.947  1.00 116.71 ? 80  GLN A NE2   1 
ATOM 510  N N     . HIS A 1 81  ? 109.449 112.832 68.327  1.00 121.54 ? 81  HIS A N     1 
ATOM 511  C CA    . HIS A 1 81  ? 108.752 112.371 67.139  1.00 121.15 ? 81  HIS A CA    1 
ATOM 512  C C     . HIS A 1 81  ? 107.718 113.356 66.618  1.00 121.41 ? 81  HIS A C     1 
ATOM 513  O O     . HIS A 1 81  ? 107.453 113.361 65.412  1.00 123.29 ? 81  HIS A O     1 
ATOM 514  C CB    . HIS A 1 81  ? 108.057 111.029 67.420  1.00 119.99 ? 81  HIS A CB    1 
ATOM 515  C CG    . HIS A 1 81  ? 107.997 110.116 66.236  1.00 121.17 ? 81  HIS A CG    1 
ATOM 516  N ND1   . HIS A 1 81  ? 109.018 109.248 65.914  1.00 121.41 ? 81  HIS A ND1   1 
ATOM 517  C CD2   . HIS A 1 81  ? 107.036 109.928 65.301  1.00 122.06 ? 81  HIS A CD2   1 
ATOM 518  C CE1   . HIS A 1 81  ? 108.691 108.568 64.830  1.00 122.48 ? 81  HIS A CE1   1 
ATOM 519  N NE2   . HIS A 1 81  ? 107.493 108.962 64.438  1.00 121.82 ? 81  HIS A NE2   1 
ATOM 520  N N     . PHE A 1 82  ? 107.131 114.179 67.482  1.00 119.51 ? 82  PHE A N     1 
ATOM 521  C CA    . PHE A 1 82  ? 106.105 115.154 67.119  1.00 120.81 ? 82  PHE A CA    1 
ATOM 522  C C     . PHE A 1 82  ? 106.443 116.514 67.719  1.00 121.75 ? 82  PHE A C     1 
ATOM 523  O O     . PHE A 1 82  ? 105.638 117.137 68.416  1.00 121.56 ? 82  PHE A O     1 
ATOM 524  C CB    . PHE A 1 82  ? 104.703 114.697 67.536  1.00 118.38 ? 82  PHE A CB    1 
ATOM 525  C CG    . PHE A 1 82  ? 104.378 113.271 67.154  1.00 119.86 ? 82  PHE A CG    1 
ATOM 526  C CD1   . PHE A 1 82  ? 103.836 112.988 65.907  1.00 121.24 ? 82  PHE A CD1   1 
ATOM 527  C CD2   . PHE A 1 82  ? 104.625 112.215 68.028  1.00 120.76 ? 82  PHE A CD2   1 
ATOM 528  C CE1   . PHE A 1 82  ? 103.537 111.684 65.539  1.00 121.88 ? 82  PHE A CE1   1 
ATOM 529  C CE2   . PHE A 1 82  ? 104.327 110.909 67.666  1.00 120.98 ? 82  PHE A CE2   1 
ATOM 530  C CZ    . PHE A 1 82  ? 103.783 110.645 66.420  1.00 121.40 ? 82  PHE A CZ    1 
ATOM 531  N N     . LYS A 1 83  ? 107.680 116.960 67.472  1.00 113.01 ? 83  LYS A N     1 
ATOM 532  C CA    . LYS A 1 83  ? 108.180 118.214 68.034  1.00 112.74 ? 83  LYS A CA    1 
ATOM 533  C C     . LYS A 1 83  ? 107.448 119.428 67.473  1.00 112.17 ? 83  LYS A C     1 
ATOM 534  O O     . LYS A 1 83  ? 107.101 120.350 68.219  1.00 112.57 ? 83  LYS A O     1 
ATOM 535  C CB    . LYS A 1 83  ? 109.678 118.338 67.757  1.00 113.64 ? 83  LYS A CB    1 
ATOM 536  C CG    . LYS A 1 83  ? 110.383 119.434 68.531  1.00 111.11 ? 83  LYS A CG    1 
ATOM 537  C CD    . LYS A 1 83  ? 111.885 119.190 68.543  1.00 110.90 ? 83  LYS A CD    1 
ATOM 538  C CE    . LYS A 1 83  ? 112.234 117.959 69.367  1.00 111.14 ? 83  LYS A CE    1 
ATOM 539  N NZ    . LYS A 1 83  ? 113.675 117.600 69.278  1.00 110.98 ? 83  LYS A NZ    1 
ATOM 540  N N     . THR A 1 84  ? 107.200 119.444 66.165  1.00 108.78 ? 84  THR A N     1 
ATOM 541  C CA    . THR A 1 84  ? 106.710 120.648 65.506  1.00 109.88 ? 84  THR A CA    1 
ATOM 542  C C     . THR A 1 84  ? 105.216 120.880 65.687  1.00 108.60 ? 84  THR A C     1 
ATOM 543  O O     . THR A 1 84  ? 104.729 121.952 65.311  1.00 110.94 ? 84  THR A O     1 
ATOM 544  C CB    . THR A 1 84  ? 107.027 120.598 64.010  1.00 109.69 ? 84  THR A CB    1 
ATOM 545  O OG1   . THR A 1 84  ? 106.613 121.823 63.391  1.00 108.85 ? 84  THR A OG1   1 
ATOM 546  C CG2   . THR A 1 84  ? 106.302 119.432 63.352  1.00 107.43 ? 84  THR A CG2   1 
ATOM 547  N N     . GLN A 1 85  ? 104.478 119.921 66.244  1.00 109.75 ? 85  GLN A N     1 
ATOM 548  C CA    . GLN A 1 85  ? 103.029 120.044 66.359  1.00 110.99 ? 85  GLN A CA    1 
ATOM 549  C C     . GLN A 1 85  ? 102.590 120.423 67.769  1.00 112.95 ? 85  GLN A C     1 
ATOM 550  O O     . GLN A 1 85  ? 101.783 121.341 67.946  1.00 115.92 ? 85  GLN A O     1 
ATOM 551  C CB    . GLN A 1 85  ? 102.355 118.740 65.909  1.00 111.37 ? 85  GLN A CB    1 
ATOM 552  C CG    . GLN A 1 85  ? 100.887 118.907 65.542  1.00 111.36 ? 85  GLN A CG    1 
ATOM 553  C CD    . GLN A 1 85  ? 100.101 117.618 65.662  1.00 113.19 ? 85  GLN A CD    1 
ATOM 554  O OE1   . GLN A 1 85  ? 100.630 116.591 66.084  1.00 114.95 ? 85  GLN A OE1   1 
ATOM 555  N NE2   . GLN A 1 85  ? 98.826  117.667 65.294  1.00 112.02 ? 85  GLN A NE2   1 
ATOM 556  N N     . ILE A 1 86  ? 103.111 119.738 68.781  1.00 113.62 ? 86  ILE A N     1 
ATOM 557  C CA    . ILE A 1 86  ? 102.636 119.946 70.148  1.00 113.34 ? 86  ILE A CA    1 
ATOM 558  C C     . ILE A 1 86  ? 103.478 120.979 70.888  1.00 113.28 ? 86  ILE A C     1 
ATOM 559  O O     . ILE A 1 86  ? 102.942 121.783 71.654  1.00 111.99 ? 86  ILE A O     1 
ATOM 560  C CB    . ILE A 1 86  ? 102.575 118.616 70.945  1.00 114.14 ? 86  ILE A CB    1 
ATOM 561  C CG1   . ILE A 1 86  ? 102.295 117.352 70.100  1.00 116.38 ? 86  ILE A CG1   1 
ATOM 562  C CG2   . ILE A 1 86  ? 101.560 118.720 72.072  1.00 113.28 ? 86  ILE A CG2   1 
ATOM 563  C CD1   . ILE A 1 86  ? 100.970 117.334 69.287  1.00 115.89 ? 86  ILE A CD1   1 
ATOM 564  N N     . PHE A 1 87  ? 104.798 120.965 70.700  1.00 112.84 ? 87  PHE A N     1 
ATOM 565  C CA    . PHE A 1 87  ? 105.705 121.713 71.562  1.00 110.67 ? 87  PHE A CA    1 
ATOM 566  C C     . PHE A 1 87  ? 106.498 122.788 70.830  1.00 109.24 ? 87  PHE A C     1 
ATOM 567  O O     . PHE A 1 87  ? 106.413 123.967 71.185  1.00 105.91 ? 87  PHE A O     1 
ATOM 568  C CB    . PHE A 1 87  ? 106.659 120.734 72.257  1.00 109.71 ? 87  PHE A CB    1 
ATOM 569  C CG    . PHE A 1 87  ? 106.028 119.429 72.604  1.00 111.67 ? 87  PHE A CG    1 
ATOM 570  C CD1   . PHE A 1 87  ? 105.200 119.331 73.706  1.00 111.73 ? 87  PHE A CD1   1 
ATOM 571  C CD2   . PHE A 1 87  ? 106.273 118.294 71.846  1.00 111.55 ? 87  PHE A CD2   1 
ATOM 572  C CE1   . PHE A 1 87  ? 104.617 118.138 74.047  1.00 110.55 ? 87  PHE A CE1   1 
ATOM 573  C CE2   . PHE A 1 87  ? 105.682 117.098 72.177  1.00 112.56 ? 87  PHE A CE2   1 
ATOM 574  C CZ    . PHE A 1 87  ? 104.865 117.023 73.285  1.00 111.35 ? 87  PHE A CZ    1 
ATOM 575  N N     . GLY A 1 88  ? 107.266 122.417 69.809  1.00 112.83 ? 88  GLY A N     1 
ATOM 576  C CA    . GLY A 1 88  ? 108.218 123.363 69.262  1.00 111.22 ? 88  GLY A CA    1 
ATOM 577  C C     . GLY A 1 88  ? 109.377 123.596 70.219  1.00 112.14 ? 88  GLY A C     1 
ATOM 578  O O     . GLY A 1 88  ? 109.808 122.702 70.954  1.00 114.53 ? 88  GLY A O     1 
ATOM 579  N N     . ASP A 1 89  ? 109.891 124.828 70.207  1.00 103.77 ? 89  ASP A N     1 
ATOM 580  C CA    . ASP A 1 89  ? 110.962 125.212 71.119  1.00 102.45 ? 89  ASP A CA    1 
ATOM 581  C C     . ASP A 1 89  ? 110.482 125.323 72.562  1.00 101.77 ? 89  ASP A C     1 
ATOM 582  O O     . ASP A 1 89  ? 111.267 125.071 73.482  1.00 98.58  ? 89  ASP A O     1 
ATOM 583  C CB    . ASP A 1 89  ? 111.589 126.532 70.657  1.00 104.46 ? 89  ASP A CB    1 
ATOM 584  C CG    . ASP A 1 89  ? 112.709 127.006 71.567  1.00 103.65 ? 89  ASP A CG    1 
ATOM 585  O OD1   . ASP A 1 89  ? 113.746 126.313 71.636  1.00 103.66 ? 89  ASP A OD1   1 
ATOM 586  O OD2   . ASP A 1 89  ? 112.551 128.062 72.213  1.00 104.22 ? 89  ASP A OD2   1 
ATOM 587  N N     . ARG A 1 90  ? 109.220 125.690 72.782  1.00 105.56 ? 90  ARG A N     1 
ATOM 588  C CA    . ARG A 1 90  ? 108.620 125.628 74.111  1.00 105.66 ? 90  ARG A CA    1 
ATOM 589  C C     . ARG A 1 90  ? 108.464 124.158 74.470  1.00 106.33 ? 90  ARG A C     1 
ATOM 590  O O     . ARG A 1 90  ? 107.894 123.391 73.694  1.00 107.73 ? 90  ARG A O     1 
ATOM 591  C CB    . ARG A 1 90  ? 107.269 126.334 74.124  1.00 105.97 ? 90  ARG A CB    1 
ATOM 592  C CG    . ARG A 1 90  ? 107.287 127.712 73.504  1.00 103.67 ? 90  ARG A CG    1 
ATOM 593  C CD    . ARG A 1 90  ? 106.260 127.767 72.395  1.00 106.57 ? 90  ARG A CD    1 
ATOM 594  N NE    . ARG A 1 90  ? 106.697 127.041 71.208  1.00 107.98 ? 90  ARG A NE    1 
ATOM 595  C CZ    . ARG A 1 90  ? 106.064 127.070 70.044  1.00 107.51 ? 90  ARG A CZ    1 
ATOM 596  N NH1   . ARG A 1 90  ? 104.955 127.771 69.879  1.00 106.16 ? 90  ARG A NH1   1 
ATOM 597  N NH2   . ARG A 1 90  ? 106.551 126.370 69.025  1.00 106.25 ? 90  ARG A NH2   1 
ATOM 598  N N     . LYS A 1 91  ? 108.997 123.748 75.617  1.00 93.28  ? 91  LYS A N     1 
ATOM 599  C CA    . LYS A 1 91  ? 108.987 122.335 75.956  1.00 93.72  ? 91  LYS A CA    1 
ATOM 600  C C     . LYS A 1 91  ? 108.497 122.109 77.373  1.00 94.53  ? 91  LYS A C     1 
ATOM 601  O O     . LYS A 1 91  ? 108.791 122.912 78.271  1.00 94.42  ? 91  LYS A O     1 
ATOM 602  C CB    . LYS A 1 91  ? 110.367 121.734 75.777  1.00 93.18  ? 91  LYS A CB    1 
ATOM 603  C CG    . LYS A 1 91  ? 111.451 122.539 76.399  1.00 91.26  ? 91  LYS A CG    1 
ATOM 604  C CD    . LYS A 1 91  ? 112.772 122.093 75.879  1.00 94.27  ? 91  LYS A CD    1 
ATOM 605  C CE    . LYS A 1 91  ? 113.031 122.485 74.445  1.00 98.15  ? 91  LYS A CE    1 
ATOM 606  N NZ    . LYS A 1 91  ? 114.426 122.162 74.038  1.00 98.89  ? 91  LYS A NZ    1 
ATOM 607  N N     . PRO A 1 92  ? 107.733 121.051 77.600  1.00 86.76  ? 92  PRO A N     1 
ATOM 608  C CA    . PRO A 1 92  ? 107.152 120.807 78.927  1.00 82.97  ? 92  PRO A CA    1 
ATOM 609  C C     . PRO A 1 92  ? 108.138 120.301 79.959  1.00 84.99  ? 92  PRO A C     1 
ATOM 610  O O     . PRO A 1 92  ? 109.308 120.035 79.675  1.00 83.84  ? 92  PRO A O     1 
ATOM 611  C CB    . PRO A 1 92  ? 106.124 119.725 78.575  1.00 81.63  ? 92  PRO A CB    1 
ATOM 612  C CG    . PRO A 1 92  ? 106.842 119.340 77.293  1.00 84.61  ? 92  PRO A CG    1 
ATOM 613  C CD    . PRO A 1 92  ? 106.717 120.489 76.692  1.00 85.25  ? 92  PRO A CD    1 
ATOM 614  N N     . VAL A 1 93  ? 107.628 120.156 81.174  1.00 81.20  ? 93  VAL A N     1 
ATOM 615  C CA    . VAL A 1 93  ? 108.353 119.540 82.255  1.00 79.02  ? 93  VAL A CA    1 
ATOM 616  C C     . VAL A 1 93  ? 107.422 118.484 82.846  1.00 80.65  ? 93  VAL A C     1 
ATOM 617  O O     . VAL A 1 93  ? 106.194 118.589 82.770  1.00 82.73  ? 93  VAL A O     1 
ATOM 618  C CB    . VAL A 1 93  ? 108.809 120.616 83.276  1.00 74.69  ? 93  VAL A CB    1 
ATOM 619  C CG1   . VAL A 1 93  ? 107.705 121.047 84.265  1.00 75.50  ? 93  VAL A CG1   1 
ATOM 620  C CG2   . VAL A 1 93  ? 110.120 120.272 83.900  1.00 75.53  ? 93  VAL A CG2   1 
ATOM 621  N N     . PHE A 1 94  ? 107.989 117.404 83.376  1.00 82.21  ? 94  PHE A N     1 
ATOM 622  C CA    . PHE A 1 94  ? 107.170 116.202 83.477  1.00 79.27  ? 94  PHE A CA    1 
ATOM 623  C C     . PHE A 1 94  ? 107.152 115.608 84.878  1.00 78.94  ? 94  PHE A C     1 
ATOM 624  O O     . PHE A 1 94  ? 108.205 115.348 85.465  1.00 80.04  ? 94  PHE A O     1 
ATOM 625  C CB    . PHE A 1 94  ? 107.652 115.152 82.471  1.00 79.25  ? 94  PHE A CB    1 
ATOM 626  C CG    . PHE A 1 94  ? 106.740 113.968 82.351  1.00 85.55  ? 94  PHE A CG    1 
ATOM 627  C CD1   . PHE A 1 94  ? 105.368 114.145 82.321  1.00 86.20  ? 94  PHE A CD1   1 
ATOM 628  C CD2   . PHE A 1 94  ? 107.247 112.682 82.243  1.00 86.12  ? 94  PHE A CD2   1 
ATOM 629  C CE1   . PHE A 1 94  ? 104.523 113.066 82.208  1.00 83.73  ? 94  PHE A CE1   1 
ATOM 630  C CE2   . PHE A 1 94  ? 106.392 111.597 82.122  1.00 81.96  ? 94  PHE A CE2   1 
ATOM 631  C CZ    . PHE A 1 94  ? 105.034 111.790 82.109  1.00 80.73  ? 94  PHE A CZ    1 
ATOM 632  N N     . ASP A 1 95  ? 105.942 115.378 85.390  1.00 75.91  ? 95  ASP A N     1 
ATOM 633  C CA    . ASP A 1 95  ? 105.747 114.496 86.534  1.00 75.63  ? 95  ASP A CA    1 
ATOM 634  C C     . ASP A 1 95  ? 105.285 113.134 86.037  1.00 80.12  ? 95  ASP A C     1 
ATOM 635  O O     . ASP A 1 95  ? 104.254 113.024 85.370  1.00 81.96  ? 95  ASP A O     1 
ATOM 636  C CB    . ASP A 1 95  ? 104.716 115.079 87.493  1.00 76.55  ? 95  ASP A CB    1 
ATOM 637  C CG    . ASP A 1 95  ? 104.311 114.099 88.577  1.00 77.23  ? 95  ASP A CG    1 
ATOM 638  O OD1   . ASP A 1 95  ? 105.196 113.419 89.137  1.00 81.69  ? 95  ASP A OD1   1 
ATOM 639  O OD2   . ASP A 1 95  ? 103.099 114.001 88.858  1.00 78.26  ? 95  ASP A OD2   1 
ATOM 640  N N     . GLY A 1 96  ? 106.011 112.086 86.420  1.00 86.51  ? 96  GLY A N     1 
ATOM 641  C CA    . GLY A 1 96  ? 106.024 110.849 85.653  1.00 84.49  ? 96  GLY A CA    1 
ATOM 642  C C     . GLY A 1 96  ? 104.785 109.979 85.758  1.00 81.40  ? 96  GLY A C     1 
ATOM 643  O O     . GLY A 1 96  ? 104.741 108.935 85.098  1.00 83.00  ? 96  GLY A O     1 
ATOM 644  N N     . ARG A 1 97  ? 103.788 110.356 86.555  1.00 86.95  ? 97  ARG A N     1 
ATOM 645  C CA    . ARG A 1 97  ? 102.569 109.563 86.639  1.00 89.37  ? 97  ARG A CA    1 
ATOM 646  C C     . ARG A 1 97  ? 101.402 110.209 85.904  1.00 91.27  ? 97  ARG A C     1 
ATOM 647  O O     . ARG A 1 97  ? 100.816 109.586 85.015  1.00 93.91  ? 97  ARG A O     1 
ATOM 648  C CB    . ARG A 1 97  ? 102.196 109.300 88.103  1.00 91.18  ? 97  ARG A CB    1 
ATOM 649  C CG    . ARG A 1 97  ? 103.344 108.764 88.930  1.00 90.42  ? 97  ARG A CG    1 
ATOM 650  C CD    . ARG A 1 97  ? 103.160 107.287 89.267  1.00 91.80  ? 97  ARG A CD    1 
ATOM 651  N NE    . ARG A 1 97  ? 101.813 106.970 89.725  1.00 90.30  ? 97  ARG A NE    1 
ATOM 652  C CZ    . ARG A 1 97  ? 101.391 107.119 90.973  1.00 93.33  ? 97  ARG A CZ    1 
ATOM 653  N NH1   . ARG A 1 97  ? 102.189 107.579 91.922  1.00 96.00  ? 97  ARG A NH1   1 
ATOM 654  N NH2   . ARG A 1 97  ? 100.138 106.791 91.277  1.00 92.55  ? 97  ARG A NH2   1 
ATOM 655  N N     . LYS A 1 98  ? 101.043 111.434 86.248  1.00 88.40  ? 98  LYS A N     1 
ATOM 656  C CA    . LYS A 1 98  ? 99.883  112.043 85.608  1.00 89.06  ? 98  LYS A CA    1 
ATOM 657  C C     . LYS A 1 98  ? 100.147 113.449 85.092  1.00 88.43  ? 98  LYS A C     1 
ATOM 658  O O     . LYS A 1 98  ? 99.650  113.808 84.023  1.00 86.62  ? 98  LYS A O     1 
ATOM 659  C CB    . LYS A 1 98  ? 98.705  112.070 86.599  1.00 90.14  ? 98  LYS A CB    1 
ATOM 660  C CG    . LYS A 1 98  ? 97.905  110.777 86.651  1.00 91.98  ? 98  LYS A CG    1 
ATOM 661  C CD    . LYS A 1 98  ? 96.944  110.647 85.485  1.00 90.06  ? 98  LYS A CD    1 
ATOM 662  C CE    . LYS A 1 98  ? 95.539  111.074 85.865  1.00 91.95  ? 98  LYS A CE    1 
ATOM 663  N NZ    . LYS A 1 98  ? 94.590  110.894 84.732  1.00 92.71  ? 98  LYS A NZ    1 
ATOM 664  N N     . ASN A 1 99  ? 100.932 114.244 85.812  1.00 87.53  ? 99  ASN A N     1 
ATOM 665  C CA    . ASN A 1 99  ? 100.973 115.683 85.600  1.00 90.33  ? 99  ASN A CA    1 
ATOM 666  C C     . ASN A 1 99  ? 101.998 116.073 84.544  1.00 89.86  ? 99  ASN A C     1 
ATOM 667  O O     . ASN A 1 99  ? 103.045 115.438 84.403  1.00 89.23  ? 99  ASN A O     1 
ATOM 668  C CB    . ASN A 1 99  ? 101.283 116.403 86.912  1.00 86.77  ? 99  ASN A CB    1 
ATOM 669  C CG    . ASN A 1 99  ? 100.236 116.152 87.974  1.00 87.79  ? 99  ASN A CG    1 
ATOM 670  O OD1   . ASN A 1 99  ? 99.600  115.098 88.001  1.00 87.27  ? 99  ASN A OD1   1 
ATOM 671  N ND2   . ASN A 1 99  ? 100.047 117.125 88.856  1.00 91.35  ? 99  ASN A ND2   1 
ATOM 672  N N     . LEU A 1 100 ? 101.692 117.145 83.816  1.00 86.31  ? 100 LEU A N     1 
ATOM 673  C CA    . LEU A 1 100 ? 102.566 117.654 82.765  1.00 81.77  ? 100 LEU A CA    1 
ATOM 674  C C     . LEU A 1 100 ? 102.477 119.172 82.821  1.00 88.08  ? 100 LEU A C     1 
ATOM 675  O O     . LEU A 1 100 ? 101.455 119.749 82.441  1.00 91.47  ? 100 LEU A O     1 
ATOM 676  C CB    . LEU A 1 100 ? 102.144 117.095 81.401  1.00 87.26  ? 100 LEU A CB    1 
ATOM 677  C CG    . LEU A 1 100 ? 102.830 117.315 80.044  1.00 91.08  ? 100 LEU A CG    1 
ATOM 678  C CD1   . LEU A 1 100 ? 102.687 118.702 79.414  1.00 89.73  ? 100 LEU A CD1   1 
ATOM 679  C CD2   . LEU A 1 100 ? 104.297 116.943 80.199  1.00 90.73  ? 100 LEU A CD2   1 
ATOM 680  N N     . TYR A 1 101 ? 103.543 119.812 83.288  1.00 88.03  ? 101 TYR A N     1 
ATOM 681  C CA    . TYR A 1 101 ? 103.603 121.258 83.451  1.00 84.82  ? 101 TYR A CA    1 
ATOM 682  C C     . TYR A 1 101 ? 104.553 121.881 82.435  1.00 86.56  ? 101 TYR A C     1 
ATOM 683  O O     . TYR A 1 101 ? 105.443 121.229 81.891  1.00 87.07  ? 101 TYR A O     1 
ATOM 684  C CB    . TYR A 1 101 ? 104.036 121.633 84.868  1.00 77.60  ? 101 TYR A CB    1 
ATOM 685  C CG    . TYR A 1 101 ? 103.232 120.994 85.975  1.00 77.95  ? 101 TYR A CG    1 
ATOM 686  C CD1   . TYR A 1 101 ? 101.846 121.020 85.992  1.00 81.31  ? 101 TYR A CD1   1 
ATOM 687  C CD2   . TYR A 1 101 ? 103.879 120.448 87.047  1.00 77.14  ? 101 TYR A CD2   1 
ATOM 688  C CE1   . TYR A 1 101 ? 101.148 120.452 87.052  1.00 82.95  ? 101 TYR A CE1   1 
ATOM 689  C CE2   . TYR A 1 101 ? 103.191 119.859 88.096  1.00 79.60  ? 101 TYR A CE2   1 
ATOM 690  C CZ    . TYR A 1 101 ? 101.827 119.869 88.091  1.00 81.06  ? 101 TYR A CZ    1 
ATOM 691  O OH    . TYR A 1 101 ? 101.131 119.303 89.132  1.00 82.49  ? 101 TYR A OH    1 
ATOM 692  N N     . THR A 1 102 ? 104.326 123.165 82.152  1.00 90.91  ? 102 THR A N     1 
ATOM 693  C CA    . THR A 1 102 ? 105.190 123.918 81.247  1.00 89.16  ? 102 THR A CA    1 
ATOM 694  C C     . THR A 1 102 ? 105.227 125.382 81.664  1.00 84.94  ? 102 THR A C     1 
ATOM 695  O O     . THR A 1 102 ? 104.175 125.981 81.905  1.00 85.95  ? 102 THR A O     1 
ATOM 696  C CB    . THR A 1 102 ? 104.705 123.836 79.794  1.00 95.55  ? 102 THR A CB    1 
ATOM 697  O OG1   . THR A 1 102 ? 104.348 122.492 79.450  1.00 95.63  ? 102 THR A OG1   1 
ATOM 698  C CG2   . THR A 1 102 ? 105.810 124.300 78.853  1.00 92.35  ? 102 THR A CG2   1 
ATOM 699  N N     . ALA A 1 103 ? 106.420 125.972 81.736  1.00 78.84  ? 103 ALA A N     1 
ATOM 700  C CA    . ALA A 1 103 ? 106.526 127.408 81.957  1.00 81.87  ? 103 ALA A CA    1 
ATOM 701  C C     . ALA A 1 103 ? 106.105 128.225 80.745  1.00 79.42  ? 103 ALA A C     1 
ATOM 702  O O     . ALA A 1 103 ? 105.500 129.288 80.914  1.00 83.28  ? 103 ALA A O     1 
ATOM 703  C CB    . ALA A 1 103 ? 107.955 127.788 82.343  1.00 83.45  ? 103 ALA A CB    1 
ATOM 704  N N     . MET A 1 104 ? 106.416 127.767 79.542  1.00 84.25  ? 104 MET A N     1 
ATOM 705  C CA    . MET A 1 104 ? 106.013 128.535 78.375  1.00 89.80  ? 104 MET A CA    1 
ATOM 706  C C     . MET A 1 104 ? 104.613 128.131 77.915  1.00 88.59  ? 104 MET A C     1 
ATOM 707  O O     . MET A 1 104 ? 104.138 127.042 78.243  1.00 86.78  ? 104 MET A O     1 
ATOM 708  C CB    . MET A 1 104 ? 107.011 128.336 77.234  1.00 92.38  ? 104 MET A CB    1 
ATOM 709  C CG    . MET A 1 104 ? 108.435 128.736 77.564  1.00 89.95  ? 104 MET A CG    1 
ATOM 710  S SD    . MET A 1 104 ? 109.168 127.703 78.836  1.00 87.25  ? 104 MET A SD    1 
ATOM 711  C CE    . MET A 1 104 ? 109.823 126.396 77.808  1.00 91.43  ? 104 MET A CE    1 
ATOM 712  N N     . PRO A 1 105 ? 103.891 128.996 77.182  1.00 95.77  ? 105 PRO A N     1 
ATOM 713  C CA    . PRO A 1 105 ? 102.631 128.564 76.559  1.00 95.00  ? 105 PRO A CA    1 
ATOM 714  C C     . PRO A 1 105 ? 102.881 127.592 75.418  1.00 94.54  ? 105 PRO A C     1 
ATOM 715  O O     . PRO A 1 105 ? 103.405 127.964 74.364  1.00 95.76  ? 105 PRO A O     1 
ATOM 716  C CB    . PRO A 1 105 ? 102.015 129.883 76.066  1.00 95.43  ? 105 PRO A CB    1 
ATOM 717  C CG    . PRO A 1 105 ? 102.701 130.955 76.821  1.00 97.25  ? 105 PRO A CG    1 
ATOM 718  C CD    . PRO A 1 105 ? 104.069 130.458 77.111  1.00 95.64  ? 105 PRO A CD    1 
ATOM 719  N N     . LEU A 1 106 ? 102.509 126.333 75.634  1.00 103.42 ? 106 LEU A N     1 
ATOM 720  C CA    . LEU A 1 106 ? 102.635 125.324 74.598  1.00 106.87 ? 106 LEU A CA    1 
ATOM 721  C C     . LEU A 1 106 ? 101.597 125.554 73.500  1.00 108.88 ? 106 LEU A C     1 
ATOM 722  O O     . LEU A 1 106 ? 100.487 126.018 73.772  1.00 107.72 ? 106 LEU A O     1 
ATOM 723  C CB    . LEU A 1 106 ? 102.456 123.928 75.184  1.00 107.18 ? 106 LEU A CB    1 
ATOM 724  C CG    . LEU A 1 106 ? 103.629 123.292 75.924  1.00 105.24 ? 106 LEU A CG    1 
ATOM 725  C CD1   . LEU A 1 106 ? 103.267 121.882 76.345  1.00 103.16 ? 106 LEU A CD1   1 
ATOM 726  C CD2   . LEU A 1 106 ? 104.855 123.287 75.042  1.00 105.30 ? 106 LEU A CD2   1 
ATOM 727  N N     . PRO A 1 107 ? 101.938 125.237 72.233  1.00 114.79 ? 107 PRO A N     1 
ATOM 728  C CA    . PRO A 1 107 ? 100.970 125.315 71.131  1.00 113.93 ? 107 PRO A CA    1 
ATOM 729  C C     . PRO A 1 107 ? 100.082 124.077 70.987  1.00 113.38 ? 107 PRO A C     1 
ATOM 730  O O     . PRO A 1 107 ? 99.953  123.505 69.903  1.00 111.85 ? 107 PRO A O     1 
ATOM 731  C CB    . PRO A 1 107 ? 101.870 125.508 69.907  1.00 112.65 ? 107 PRO A CB    1 
ATOM 732  C CG    . PRO A 1 107 ? 103.130 124.814 70.269  1.00 111.07 ? 107 PRO A CG    1 
ATOM 733  C CD    . PRO A 1 107 ? 103.315 125.053 71.740  1.00 110.90 ? 107 PRO A CD    1 
ATOM 734  N N     . ILE A 1 108 ? 99.464  123.658 72.094  1.00 118.15 ? 108 ILE A N     1 
ATOM 735  C CA    . ILE A 1 108 ? 98.487  122.580 72.085  1.00 118.75 ? 108 ILE A CA    1 
ATOM 736  C C     . ILE A 1 108 ? 97.119  123.046 72.577  1.00 118.97 ? 108 ILE A C     1 
ATOM 737  O O     . ILE A 1 108 ? 96.101  122.764 71.933  1.00 117.55 ? 108 ILE A O     1 
ATOM 738  C CB    . ILE A 1 108 ? 98.994  121.347 72.887  1.00 118.51 ? 108 ILE A CB    1 
ATOM 739  C CG1   . ILE A 1 108 ? 97.960  120.212 72.911  1.00 119.21 ? 108 ILE A CG1   1 
ATOM 740  C CG2   . ILE A 1 108 ? 99.572  121.712 74.264  1.00 116.51 ? 108 ILE A CG2   1 
ATOM 741  C CD1   . ILE A 1 108 ? 97.590  119.688 71.535  1.00 118.47 ? 108 ILE A CD1   1 
ATOM 742  N N     . GLY A 1 109 ? 97.072  123.792 73.683  1.00 121.65 ? 109 GLY A N     1 
ATOM 743  C CA    . GLY A 1 109 ? 95.867  124.492 74.103  1.00 121.65 ? 109 GLY A CA    1 
ATOM 744  C C     . GLY A 1 109 ? 94.743  123.583 74.563  1.00 122.61 ? 109 GLY A C     1 
ATOM 745  O O     . GLY A 1 109 ? 94.956  122.549 75.206  1.00 123.09 ? 109 GLY A O     1 
ATOM 746  N N     . ARG A 1 110 ? 93.516  123.987 74.216  1.00 134.10 ? 110 ARG A N     1 
ATOM 747  C CA    . ARG A 1 110 ? 92.303  123.272 74.600  1.00 135.89 ? 110 ARG A CA    1 
ATOM 748  C C     . ARG A 1 110 ? 92.155  121.947 73.855  1.00 137.36 ? 110 ARG A C     1 
ATOM 749  O O     . ARG A 1 110 ? 91.500  121.030 74.369  1.00 137.45 ? 110 ARG A O     1 
ATOM 750  C CB    . ARG A 1 110 ? 91.097  124.195 74.353  1.00 134.82 ? 110 ARG A CB    1 
ATOM 751  C CG    . ARG A 1 110 ? 89.719  123.663 74.740  1.00 134.61 ? 110 ARG A CG    1 
ATOM 752  C CD    . ARG A 1 110 ? 89.675  123.310 76.214  1.00 134.72 ? 110 ARG A CD    1 
ATOM 753  N NE    . ARG A 1 110 ? 89.785  124.494 77.056  1.00 135.40 ? 110 ARG A NE    1 
ATOM 754  C CZ    . ARG A 1 110 ? 90.346  124.509 78.257  1.00 134.86 ? 110 ARG A CZ    1 
ATOM 755  N NH1   . ARG A 1 110 ? 90.875  123.417 78.786  1.00 134.64 ? 110 ARG A NH1   1 
ATOM 756  N NH2   . ARG A 1 110 ? 90.379  125.648 78.943  1.00 134.14 ? 110 ARG A NH2   1 
ATOM 757  N N     . ASP A 1 111 ? 92.796  121.816 72.690  1.00 138.00 ? 111 ASP A N     1 
ATOM 758  C CA    . ASP A 1 111 ? 92.624  120.672 71.795  1.00 137.73 ? 111 ASP A CA    1 
ATOM 759  C C     . ASP A 1 111 ? 93.185  119.406 72.434  1.00 137.19 ? 111 ASP A C     1 
ATOM 760  O O     . ASP A 1 111 ? 94.401  119.269 72.600  1.00 137.13 ? 111 ASP A O     1 
ATOM 761  C CB    . ASP A 1 111 ? 93.315  120.951 70.465  1.00 137.11 ? 111 ASP A CB    1 
ATOM 762  C CG    . ASP A 1 111 ? 93.045  122.349 69.950  1.00 136.11 ? 111 ASP A CG    1 
ATOM 763  O OD1   . ASP A 1 111 ? 93.360  123.319 70.672  1.00 135.80 ? 111 ASP A OD1   1 
ATOM 764  O OD2   . ASP A 1 111 ? 92.522  122.481 68.824  1.00 136.35 ? 111 ASP A OD2   1 
ATOM 765  N N     . LYS A 1 112 ? 92.297  118.480 72.795  1.00 139.75 ? 112 LYS A N     1 
ATOM 766  C CA    . LYS A 1 112 ? 92.698  117.228 73.433  1.00 140.56 ? 112 LYS A CA    1 
ATOM 767  C C     . LYS A 1 112 ? 93.067  116.238 72.339  1.00 141.33 ? 112 LYS A C     1 
ATOM 768  O O     . LYS A 1 112 ? 92.215  115.548 71.777  1.00 141.66 ? 112 LYS A O     1 
ATOM 769  C CB    . LYS A 1 112 ? 91.595  116.688 74.336  1.00 141.24 ? 112 LYS A CB    1 
ATOM 770  C CG    . LYS A 1 112 ? 92.005  115.445 75.122  1.00 141.14 ? 112 LYS A CG    1 
ATOM 771  C CD    . LYS A 1 112 ? 90.891  114.956 76.036  1.00 141.34 ? 112 LYS A CD    1 
ATOM 772  C CE    . LYS A 1 112 ? 91.447  114.212 77.243  1.00 141.54 ? 112 LYS A CE    1 
ATOM 773  N NZ    . LYS A 1 112 ? 90.394  113.892 78.246  1.00 141.64 ? 112 LYS A NZ    1 
ATOM 774  N N     . VAL A 1 113 ? 94.358  116.174 72.030  1.00 139.12 ? 113 VAL A N     1 
ATOM 775  C CA    . VAL A 1 113 ? 94.860  115.241 71.029  1.00 139.88 ? 113 VAL A CA    1 
ATOM 776  C C     . VAL A 1 113 ? 95.107  113.904 71.719  1.00 140.43 ? 113 VAL A C     1 
ATOM 777  O O     . VAL A 1 113 ? 95.963  113.795 72.601  1.00 139.63 ? 113 VAL A O     1 
ATOM 778  C CB    . VAL A 1 113 ? 96.133  115.766 70.355  1.00 139.46 ? 113 VAL A CB    1 
ATOM 779  C CG1   . VAL A 1 113 ? 96.764  114.686 69.483  1.00 138.53 ? 113 VAL A CG1   1 
ATOM 780  C CG2   . VAL A 1 113 ? 95.818  117.004 69.534  1.00 139.57 ? 113 VAL A CG2   1 
ATOM 781  N N     . GLU A 1 114 ? 94.339  112.885 71.331  1.00 136.48 ? 114 GLU A N     1 
ATOM 782  C CA    . GLU A 1 114 ? 94.557  111.518 71.798  1.00 135.62 ? 114 GLU A CA    1 
ATOM 783  C C     . GLU A 1 114 ? 95.642  110.857 70.944  1.00 135.17 ? 114 GLU A C     1 
ATOM 784  O O     . GLU A 1 114 ? 95.374  110.040 70.063  1.00 136.28 ? 114 GLU A O     1 
ATOM 785  C CB    . GLU A 1 114 ? 93.259  110.722 71.751  1.00 135.48 ? 114 GLU A CB    1 
ATOM 786  C CG    . GLU A 1 114 ? 92.211  111.138 72.771  1.00 136.16 ? 114 GLU A CG    1 
ATOM 787  C CD    . GLU A 1 114 ? 91.289  112.227 72.261  1.00 135.78 ? 114 GLU A CD    1 
ATOM 788  O OE1   . GLU A 1 114 ? 91.345  112.540 71.053  1.00 135.70 ? 114 GLU A OE1   1 
ATOM 789  O OE2   . GLU A 1 114 ? 90.502  112.764 73.068  1.00 135.04 ? 114 GLU A OE2   1 
ATOM 790  N N     . LEU A 1 115 ? 96.887  111.248 71.216  1.00 126.64 ? 115 LEU A N     1 
ATOM 791  C CA    . LEU A 1 115 ? 98.002  110.848 70.368  1.00 125.40 ? 115 LEU A CA    1 
ATOM 792  C C     . LEU A 1 115 ? 98.337  109.381 70.601  1.00 126.02 ? 115 LEU A C     1 
ATOM 793  O O     . LEU A 1 115 ? 98.376  108.910 71.740  1.00 125.77 ? 115 LEU A O     1 
ATOM 794  C CB    . LEU A 1 115 ? 99.209  111.758 70.635  1.00 127.54 ? 115 LEU A CB    1 
ATOM 795  C CG    . LEU A 1 115 ? 100.590 111.658 69.954  1.00 129.13 ? 115 LEU A CG    1 
ATOM 796  C CD1   . LEU A 1 115 ? 101.559 110.630 70.547  1.00 127.78 ? 115 LEU A CD1   1 
ATOM 797  C CD2   . LEU A 1 115 ? 100.413 111.414 68.457  1.00 127.66 ? 115 LEU A CD2   1 
ATOM 798  N N     . GLU A 1 116 ? 98.574  108.663 69.513  1.00 136.38 ? 116 GLU A N     1 
ATOM 799  C CA    . GLU A 1 116 ? 98.832  107.229 69.538  1.00 137.46 ? 116 GLU A CA    1 
ATOM 800  C C     . GLU A 1 116 ? 100.333 107.027 69.357  1.00 137.08 ? 116 GLU A C     1 
ATOM 801  O O     . GLU A 1 116 ? 100.874 107.232 68.270  1.00 136.65 ? 116 GLU A O     1 
ATOM 802  C CB    . GLU A 1 116 ? 98.031  106.521 68.453  1.00 138.01 ? 116 GLU A CB    1 
ATOM 803  C CG    . GLU A 1 116 ? 98.043  105.013 68.555  1.00 137.30 ? 116 GLU A CG    1 
ATOM 804  C CD    . GLU A 1 116 ? 97.566  104.342 67.283  1.00 137.29 ? 116 GLU A CD    1 
ATOM 805  O OE1   . GLU A 1 116 ? 96.854  105.000 66.495  1.00 138.03 ? 116 GLU A OE1   1 
ATOM 806  O OE2   . GLU A 1 116 ? 97.902  103.159 67.071  1.00 137.94 ? 116 GLU A OE2   1 
ATOM 807  N N     . VAL A 1 117 ? 101.006 106.628 70.438  1.00 135.08 ? 117 VAL A N     1 
ATOM 808  C CA    . VAL A 1 117 ? 102.438 106.382 70.358  1.00 135.04 ? 117 VAL A CA    1 
ATOM 809  C C     . VAL A 1 117 ? 102.677 105.062 69.647  1.00 134.31 ? 117 VAL A C     1 
ATOM 810  O O     . VAL A 1 117 ? 102.181 104.007 70.063  1.00 133.32 ? 117 VAL A O     1 
ATOM 811  C CB    . VAL A 1 117 ? 103.075 106.376 71.757  1.00 135.28 ? 117 VAL A CB    1 
ATOM 812  C CG1   . VAL A 1 117 ? 104.571 106.156 71.648  1.00 134.18 ? 117 VAL A CG1   1 
ATOM 813  C CG2   . VAL A 1 117 ? 102.780 107.668 72.486  1.00 133.85 ? 117 VAL A CG2   1 
ATOM 814  N N     . THR A 1 118 ? 103.444 105.114 68.559  1.00 144.41 ? 118 THR A N     1 
ATOM 815  C CA    . THR A 1 118 ? 103.716 103.940 67.734  1.00 145.79 ? 118 THR A CA    1 
ATOM 816  C C     . THR A 1 118 ? 105.202 103.620 67.840  1.00 145.36 ? 118 THR A C     1 
ATOM 817  O O     . THR A 1 118 ? 106.003 104.057 67.009  1.00 144.75 ? 118 THR A O     1 
ATOM 818  C CB    . THR A 1 118 ? 103.293 104.173 66.283  1.00 145.25 ? 118 THR A CB    1 
ATOM 819  O OG1   . THR A 1 118 ? 102.014 104.820 66.253  1.00 144.81 ? 118 THR A OG1   1 
ATOM 820  C CG2   . THR A 1 118 ? 103.201 102.851 65.535  1.00 143.98 ? 118 THR A CG2   1 
ATOM 821  N N     . LEU A 1 119 ? 105.569 102.862 68.866  1.00 142.41 ? 119 LEU A N     1 
ATOM 822  C CA    . LEU A 1 119 ? 106.889 102.249 68.899  1.00 141.84 ? 119 LEU A CA    1 
ATOM 823  C C     . LEU A 1 119 ? 106.898 101.075 67.929  1.00 142.76 ? 119 LEU A C     1 
ATOM 824  O O     . LEU A 1 119 ? 106.051 100.182 68.051  1.00 143.06 ? 119 LEU A O     1 
ATOM 825  C CB    . LEU A 1 119 ? 107.247 101.777 70.303  1.00 141.69 ? 119 LEU A CB    1 
ATOM 826  C CG    . LEU A 1 119 ? 108.124 102.666 71.195  1.00 140.52 ? 119 LEU A CG    1 
ATOM 827  C CD1   . LEU A 1 119 ? 109.581 102.568 70.773  1.00 140.20 ? 119 LEU A CD1   1 
ATOM 828  C CD2   . LEU A 1 119 ? 107.674 104.113 71.214  1.00 140.67 ? 119 LEU A CD2   1 
ATOM 829  N N     . PRO A 1 120 ? 107.794 101.054 66.943  1.00 151.34 ? 120 PRO A N     1 
ATOM 830  C CA    . PRO A 1 120 ? 107.793 99.957  65.968  1.00 152.48 ? 120 PRO A CA    1 
ATOM 831  C C     . PRO A 1 120 ? 108.268 98.649  66.580  1.00 151.88 ? 120 PRO A C     1 
ATOM 832  O O     . PRO A 1 120 ? 109.074 98.624  67.513  1.00 150.46 ? 120 PRO A O     1 
ATOM 833  C CB    . PRO A 1 120 ? 108.755 100.448 64.880  1.00 151.89 ? 120 PRO A CB    1 
ATOM 834  C CG    . PRO A 1 120 ? 109.644 101.425 65.568  1.00 150.74 ? 120 PRO A CG    1 
ATOM 835  C CD    . PRO A 1 120 ? 108.838 102.056 66.664  1.00 150.18 ? 120 PRO A CD    1 
ATOM 836  N N     . GLY A 1 121 ? 107.744 97.553  66.044  1.00 149.41 ? 121 GLY A N     1 
ATOM 837  C CA    . GLY A 1 121 ? 108.023 96.251  66.599  1.00 147.90 ? 121 GLY A CA    1 
ATOM 838  C C     . GLY A 1 121 ? 108.032 95.180  65.534  1.00 148.11 ? 121 GLY A C     1 
ATOM 839  O O     . GLY A 1 121 ? 107.888 95.457  64.341  1.00 147.17 ? 121 GLY A O     1 
ATOM 840  N N     . GLU A 1 122 ? 108.259 93.944  65.999  1.00 151.79 ? 122 GLU A N     1 
ATOM 841  C CA    . GLU A 1 122 ? 108.277 92.768  65.095  1.00 151.98 ? 122 GLU A CA    1 
ATOM 842  C C     . GLU A 1 122 ? 106.823 92.413  64.782  1.00 152.30 ? 122 GLU A C     1 
ATOM 843  O O     . GLU A 1 122 ? 106.282 91.488  65.416  1.00 151.94 ? 122 GLU A O     1 
ATOM 844  C CB    . GLU A 1 122 ? 109.027 91.627  65.784  1.00 152.52 ? 122 GLU A CB    1 
ATOM 845  C CG    . GLU A 1 122 ? 108.896 91.639  67.306  1.00 152.05 ? 122 GLU A CG    1 
ATOM 846  C CD    . GLU A 1 122 ? 109.938 92.443  68.066  1.00 152.55 ? 122 GLU A CD    1 
ATOM 847  O OE1   . GLU A 1 122 ? 110.696 93.193  67.414  1.00 151.87 ? 122 GLU A OE1   1 
ATOM 848  O OE2   . GLU A 1 122 ? 109.983 92.329  69.309  1.00 153.54 ? 122 GLU A OE2   1 
ATOM 849  N N     . GLY A 1 123 ? 106.215 93.145  63.856  1.00 150.75 ? 123 GLY A N     1 
ATOM 850  C CA    . GLY A 1 123 ? 104.825 92.937  63.502  1.00 150.29 ? 123 GLY A CA    1 
ATOM 851  C C     . GLY A 1 123 ? 103.881 93.675  64.428  1.00 150.05 ? 123 GLY A C     1 
ATOM 852  O O     . GLY A 1 123 ? 103.201 94.618  64.014  1.00 150.45 ? 123 GLY A O     1 
ATOM 853  N N     . LYS A 1 124 ? 103.837 93.254  65.690  1.00 145.80 ? 124 LYS A N     1 
ATOM 854  C CA    . LYS A 1 124 ? 103.010 93.904  66.705  1.00 146.46 ? 124 LYS A CA    1 
ATOM 855  C C     . LYS A 1 124 ? 103.743 95.144  67.197  1.00 146.46 ? 124 LYS A C     1 
ATOM 856  O O     . LYS A 1 124 ? 104.787 95.049  67.845  1.00 145.35 ? 124 LYS A O     1 
ATOM 857  C CB    . LYS A 1 124 ? 102.715 92.939  67.849  1.00 147.05 ? 124 LYS A CB    1 
ATOM 858  C CG    . LYS A 1 124 ? 102.053 93.564  69.073  1.00 147.66 ? 124 LYS A CG    1 
ATOM 859  C CD    . LYS A 1 124 ? 100.700 94.181  68.750  1.00 146.78 ? 124 LYS A CD    1 
ATOM 860  C CE    . LYS A 1 124 ? 100.053 94.756  70.003  1.00 144.33 ? 124 LYS A CE    1 
ATOM 861  N NZ    . LYS A 1 124 ? 98.864  95.600  69.693  1.00 143.12 ? 124 LYS A NZ    1 
ATOM 862  N N     . ASP A 1 125 ? 103.202 96.316  66.879  1.00 146.06 ? 125 ASP A N     1 
ATOM 863  C CA    . ASP A 1 125 ? 103.760 97.559  67.384  1.00 144.55 ? 125 ASP A CA    1 
ATOM 864  C C     . ASP A 1 125 ? 103.208 97.868  68.775  1.00 143.86 ? 125 ASP A C     1 
ATOM 865  O O     . ASP A 1 125 ? 102.079 97.507  69.122  1.00 144.46 ? 125 ASP A O     1 
ATOM 866  C CB    . ASP A 1 125 ? 103.470 98.710  66.418  1.00 144.96 ? 125 ASP A CB    1 
ATOM 867  C CG    . ASP A 1 125 ? 102.002 98.796  66.023  1.00 145.66 ? 125 ASP A CG    1 
ATOM 868  O OD1   . ASP A 1 125 ? 101.225 97.876  66.354  1.00 146.46 ? 125 ASP A OD1   1 
ATOM 869  O OD2   . ASP A 1 125 ? 101.626 99.788  65.365  1.00 145.40 ? 125 ASP A OD2   1 
ATOM 870  N N     . ARG A 1 126 ? 104.025 98.545  69.579  1.00 136.37 ? 126 ARG A N     1 
ATOM 871  C CA    . ARG A 1 126 ? 103.666 98.878  70.955  1.00 135.73 ? 126 ARG A CA    1 
ATOM 872  C C     . ARG A 1 126 ? 102.865 100.173 70.928  1.00 133.61 ? 126 ARG A C     1 
ATOM 873  O O     . ARG A 1 126 ? 103.413 101.255 70.706  1.00 133.96 ? 126 ARG A O     1 
ATOM 874  C CB    . ARG A 1 126 ? 104.904 99.000  71.833  1.00 133.97 ? 126 ARG A CB    1 
ATOM 875  C CG    . ARG A 1 126 ? 104.607 98.839  73.310  1.00 133.70 ? 126 ARG A CG    1 
ATOM 876  C CD    . ARG A 1 126 ? 103.907 97.519  73.596  1.00 135.06 ? 126 ARG A CD    1 
ATOM 877  N NE    . ARG A 1 126 ? 104.131 97.058  74.960  1.00 134.11 ? 126 ARG A NE    1 
ATOM 878  C CZ    . ARG A 1 126 ? 105.202 96.386  75.358  1.00 134.90 ? 126 ARG A CZ    1 
ATOM 879  N NH1   . ARG A 1 126 ? 106.181 96.084  74.521  1.00 134.82 ? 126 ARG A NH1   1 
ATOM 880  N NH2   . ARG A 1 126 ? 105.294 96.006  76.629  1.00 135.23 ? 126 ARG A NH2   1 
ATOM 881  N N     . ILE A 1 127 ? 101.565 100.056 71.163  1.00 132.26 ? 127 ILE A N     1 
ATOM 882  C CA    . ILE A 1 127 ? 100.640 101.170 71.009  1.00 132.58 ? 127 ILE A CA    1 
ATOM 883  C C     . ILE A 1 127 ? 100.287 101.727 72.379  1.00 132.65 ? 127 ILE A C     1 
ATOM 884  O O     . ILE A 1 127 ? 99.756  101.012 73.238  1.00 133.07 ? 127 ILE A O     1 
ATOM 885  C CB    . ILE A 1 127 ? 99.382  100.725 70.244  1.00 132.26 ? 127 ILE A CB    1 
ATOM 886  C CG1   . ILE A 1 127 ? 99.721  100.407 68.780  1.00 131.76 ? 127 ILE A CG1   1 
ATOM 887  C CG2   . ILE A 1 127 ? 98.286  101.772 70.336  1.00 131.76 ? 127 ILE A CG2   1 
ATOM 888  C CD1   . ILE A 1 127 ? 100.617 101.434 68.092  1.00 131.32 ? 127 ILE A CD1   1 
ATOM 889  N N     . PHE A 1 128 ? 100.588 103.008 72.585  1.00 123.76 ? 128 PHE A N     1 
ATOM 890  C CA    . PHE A 1 128 ? 100.216 103.727 73.796  1.00 122.08 ? 128 PHE A CA    1 
ATOM 891  C C     . PHE A 1 128 ? 99.246  104.829 73.410  1.00 122.65 ? 128 PHE A C     1 
ATOM 892  O O     . PHE A 1 128 ? 99.545  105.642 72.530  1.00 124.39 ? 128 PHE A O     1 
ATOM 893  C CB    . PHE A 1 128 ? 101.441 104.314 74.499  1.00 122.33 ? 128 PHE A CB    1 
ATOM 894  C CG    . PHE A 1 128 ? 102.413 103.284 74.984  1.00 121.94 ? 128 PHE A CG    1 
ATOM 895  C CD1   . PHE A 1 128 ? 102.135 102.527 76.113  1.00 122.91 ? 128 PHE A CD1   1 
ATOM 896  C CD2   . PHE A 1 128 ? 103.607 103.071 74.314  1.00 122.42 ? 128 PHE A CD2   1 
ATOM 897  C CE1   . PHE A 1 128 ? 103.035 101.575 76.567  1.00 123.80 ? 128 PHE A CE1   1 
ATOM 898  C CE2   . PHE A 1 128 ? 104.510 102.126 74.762  1.00 123.43 ? 128 PHE A CE2   1 
ATOM 899  C CZ    . PHE A 1 128 ? 104.222 101.377 75.891  1.00 124.52 ? 128 PHE A CZ    1 
ATOM 900  N N     . LYS A 1 129 ? 98.090  104.854 74.063  1.00 119.26 ? 129 LYS A N     1 
ATOM 901  C CA    . LYS A 1 129 ? 97.032  105.812 73.754  1.00 120.55 ? 129 LYS A CA    1 
ATOM 902  C C     . LYS A 1 129 ? 97.025  106.862 74.859  1.00 121.75 ? 129 LYS A C     1 
ATOM 903  O O     . LYS A 1 129 ? 96.433  106.673 75.922  1.00 121.80 ? 129 LYS A O     1 
ATOM 904  C CB    . LYS A 1 129 ? 95.684  105.111 73.612  1.00 119.19 ? 129 LYS A CB    1 
ATOM 905  C CG    . LYS A 1 129 ? 95.724  103.821 72.788  1.00 119.49 ? 129 LYS A CG    1 
ATOM 906  C CD    . LYS A 1 129 ? 95.687  102.571 73.663  1.00 120.62 ? 129 LYS A CD    1 
ATOM 907  C CE    . LYS A 1 129 ? 95.492  101.315 72.834  1.00 121.03 ? 129 LYS A CE    1 
ATOM 908  N NZ    . LYS A 1 129 ? 95.726  100.086 73.641  1.00 118.98 ? 129 LYS A NZ    1 
ATOM 909  N N     . VAL A 1 130 ? 97.695  107.983 74.596  1.00 124.46 ? 130 VAL A N     1 
ATOM 910  C CA    . VAL A 1 130 ? 97.839  109.074 75.553  1.00 123.40 ? 130 VAL A CA    1 
ATOM 911  C C     . VAL A 1 130 ? 97.074  110.280 75.025  1.00 126.69 ? 130 VAL A C     1 
ATOM 912  O O     . VAL A 1 130 ? 97.099  110.563 73.820  1.00 128.58 ? 130 VAL A O     1 
ATOM 913  C CB    . VAL A 1 130 ? 99.320  109.424 75.801  1.00 123.11 ? 130 VAL A CB    1 
ATOM 914  C CG1   . VAL A 1 130 ? 99.928  108.467 76.801  1.00 122.24 ? 130 VAL A CG1   1 
ATOM 915  C CG2   . VAL A 1 130 ? 100.117 109.397 74.510  1.00 122.80 ? 130 VAL A CG2   1 
ATOM 916  N N     . SER A 1 131 ? 96.373  110.973 75.917  1.00 131.87 ? 131 SER A N     1 
ATOM 917  C CA    . SER A 1 131 ? 95.669  112.199 75.575  1.00 131.69 ? 131 SER A CA    1 
ATOM 918  C C     . SER A 1 131 ? 96.209  113.350 76.410  1.00 132.21 ? 131 SER A C     1 
ATOM 919  O O     . SER A 1 131 ? 96.409  113.213 77.621  1.00 130.10 ? 131 SER A O     1 
ATOM 920  C CB    . SER A 1 131 ? 94.160  112.056 75.781  1.00 129.43 ? 131 SER A CB    1 
ATOM 921  O OG    . SER A 1 131 ? 93.869  111.225 76.885  1.00 129.60 ? 131 SER A OG    1 
ATOM 922  N N     . ILE A 1 132 ? 96.443  114.483 75.754  1.00 133.99 ? 132 ILE A N     1 
ATOM 923  C CA    . ILE A 1 132 ? 97.004  115.674 76.384  1.00 133.98 ? 132 ILE A CA    1 
ATOM 924  C C     . ILE A 1 132 ? 95.851  116.662 76.485  1.00 134.46 ? 132 ILE A C     1 
ATOM 925  O O     . ILE A 1 132 ? 95.259  117.031 75.464  1.00 134.07 ? 132 ILE A O     1 
ATOM 926  C CB    . ILE A 1 132 ? 98.184  116.281 75.595  1.00 136.39 ? 132 ILE A CB    1 
ATOM 927  C CG1   . ILE A 1 132 ? 99.518  115.537 75.808  1.00 135.33 ? 132 ILE A CG1   1 
ATOM 928  C CG2   . ILE A 1 132 ? 98.412  117.750 75.978  1.00 134.46 ? 132 ILE A CG2   1 
ATOM 929  C CD1   . ILE A 1 132 ? 99.668  114.124 75.233  1.00 132.43 ? 132 ILE A CD1   1 
ATOM 930  N N     . LYS A 1 133 ? 95.512  117.072 77.702  1.00 128.91 ? 133 LYS A N     1 
ATOM 931  C CA    . LYS A 1 133 ? 94.399  117.982 77.925  1.00 130.29 ? 133 LYS A CA    1 
ATOM 932  C C     . LYS A 1 133 ? 94.812  119.107 78.863  1.00 128.95 ? 133 LYS A C     1 
ATOM 933  O O     . LYS A 1 133 ? 95.360  118.854 79.940  1.00 127.20 ? 133 LYS A O     1 
ATOM 934  C CB    . LYS A 1 133 ? 93.192  117.236 78.503  1.00 129.47 ? 133 LYS A CB    1 
ATOM 935  C CG    . LYS A 1 133 ? 91.999  118.124 78.816  1.00 128.95 ? 133 LYS A CG    1 
ATOM 936  C CD    . LYS A 1 133 ? 91.369  118.659 77.537  1.00 128.64 ? 133 LYS A CD    1 
ATOM 937  C CE    . LYS A 1 133 ? 89.960  119.176 77.777  1.00 129.06 ? 133 LYS A CE    1 
ATOM 938  N NZ    . LYS A 1 133 ? 89.824  119.823 79.111  1.00 127.98 ? 133 LYS A NZ    1 
ATOM 939  N N     . TRP A 1 134 ? 94.542  120.345 78.440  1.00 118.85 ? 134 TRP A N     1 
ATOM 940  C CA    . TRP A 1 134 ? 94.733  121.516 79.289  1.00 117.54 ? 134 TRP A CA    1 
ATOM 941  C C     . TRP A 1 134 ? 93.828  121.449 80.510  1.00 118.76 ? 134 TRP A C     1 
ATOM 942  O O     . TRP A 1 134 ? 92.635  121.154 80.400  1.00 119.37 ? 134 TRP A O     1 
ATOM 943  C CB    . TRP A 1 134 ? 94.431  122.788 78.496  1.00 117.30 ? 134 TRP A CB    1 
ATOM 944  C CG    . TRP A 1 134 ? 95.021  124.054 79.057  1.00 117.35 ? 134 TRP A CG    1 
ATOM 945  C CD1   . TRP A 1 134 ? 96.249  124.578 78.789  1.00 118.34 ? 134 TRP A CD1   1 
ATOM 946  C CD2   . TRP A 1 134 ? 94.390  124.962 79.970  1.00 118.08 ? 134 TRP A CD2   1 
ATOM 947  N NE1   . TRP A 1 134 ? 96.427  125.753 79.479  1.00 119.04 ? 134 TRP A NE1   1 
ATOM 948  C CE2   . TRP A 1 134 ? 95.299  126.010 80.212  1.00 118.62 ? 134 TRP A CE2   1 
ATOM 949  C CE3   . TRP A 1 134 ? 93.147  124.987 80.609  1.00 118.07 ? 134 TRP A CE3   1 
ATOM 950  C CZ2   . TRP A 1 134 ? 95.003  127.075 81.061  1.00 117.75 ? 134 TRP A CZ2   1 
ATOM 951  C CZ3   . TRP A 1 134 ? 92.854  126.046 81.453  1.00 118.40 ? 134 TRP A CZ3   1 
ATOM 952  C CH2   . TRP A 1 134 ? 93.779  127.075 81.671  1.00 117.59 ? 134 TRP A CH2   1 
ATOM 953  N N     . VAL A 1 135 ? 94.402  121.712 81.680  1.00 113.22 ? 135 VAL A N     1 
ATOM 954  C CA    . VAL A 1 135 ? 93.666  121.693 82.939  1.00 113.14 ? 135 VAL A CA    1 
ATOM 955  C C     . VAL A 1 135 ? 93.604  123.082 83.564  1.00 112.03 ? 135 VAL A C     1 
ATOM 956  O O     . VAL A 1 135 ? 92.520  123.609 83.820  1.00 114.49 ? 135 VAL A O     1 
ATOM 957  C CB    . VAL A 1 135 ? 94.265  120.663 83.921  1.00 114.20 ? 135 VAL A CB    1 
ATOM 958  C CG1   . VAL A 1 135 ? 93.518  120.711 85.243  1.00 112.41 ? 135 VAL A CG1   1 
ATOM 959  C CG2   . VAL A 1 135 ? 94.222  119.270 83.327  1.00 113.79 ? 135 VAL A CG2   1 
ATOM 960  N N     . SER A 1 136 ? 94.759  123.691 83.817  1.00 110.21 ? 136 SER A N     1 
ATOM 961  C CA    . SER A 1 136 ? 94.799  124.994 84.466  1.00 112.49 ? 136 SER A CA    1 
ATOM 962  C C     . SER A 1 136 ? 96.067  125.718 84.042  1.00 111.15 ? 136 SER A C     1 
ATOM 963  O O     . SER A 1 136 ? 96.991  125.120 83.486  1.00 110.32 ? 136 SER A O     1 
ATOM 964  C CB    . SER A 1 136 ? 94.743  124.869 85.992  1.00 111.65 ? 136 SER A CB    1 
ATOM 965  O OG    . SER A 1 136 ? 95.996  124.459 86.512  1.00 112.84 ? 136 SER A OG    1 
ATOM 966  N N     . CYS A 1 137 ? 96.075  127.024 84.278  1.00 100.93 ? 137 CYS A N     1 
ATOM 967  C CA    . CYS A 1 137 ? 97.271  127.858 84.185  1.00 99.96  ? 137 CYS A CA    1 
ATOM 968  C C     . CYS A 1 137 ? 97.589  128.279 85.616  1.00 100.45 ? 137 CYS A C     1 
ATOM 969  O O     . CYS A 1 137 ? 96.930  129.156 86.177  1.00 101.21 ? 137 CYS A O     1 
ATOM 970  C CB    . CYS A 1 137 ? 97.049  129.062 83.273  1.00 101.93 ? 137 CYS A CB    1 
ATOM 971  S SG    . CYS A 1 137 ? 98.433  130.219 83.199  1.00 103.83 ? 137 CYS A SG    1 
ATOM 972  N N     . VAL A 1 138 ? 98.599  127.637 86.206  1.00 86.72  ? 138 VAL A N     1 
ATOM 973  C CA    . VAL A 1 138 ? 98.873  127.831 87.624  1.00 87.05  ? 138 VAL A CA    1 
ATOM 974  C C     . VAL A 1 138 ? 99.527  129.185 87.839  1.00 85.37  ? 138 VAL A C     1 
ATOM 975  O O     . VAL A 1 138 ? 100.624 129.455 87.335  1.00 86.04  ? 138 VAL A O     1 
ATOM 976  C CB    . VAL A 1 138 ? 99.750  126.690 88.159  1.00 88.11  ? 138 VAL A CB    1 
ATOM 977  C CG1   . VAL A 1 138 ? 99.792  126.719 89.673  1.00 88.56  ? 138 VAL A CG1   1 
ATOM 978  C CG2   . VAL A 1 138 ? 99.234  125.357 87.648  1.00 85.88  ? 138 VAL A CG2   1 
ATOM 979  N N     . SER A 1 139 ? 98.844  130.048 88.586  1.00 74.08  ? 139 SER A N     1 
ATOM 980  C CA    . SER A 1 139 ? 99.318  131.395 88.866  1.00 77.52  ? 139 SER A CA    1 
ATOM 981  C C     . SER A 1 139 ? 100.430 131.317 89.901  1.00 77.51  ? 139 SER A C     1 
ATOM 982  O O     . SER A 1 139 ? 100.246 130.736 90.976  1.00 75.94  ? 139 SER A O     1 
ATOM 983  C CB    . SER A 1 139 ? 98.181  132.286 89.366  1.00 75.96  ? 139 SER A CB    1 
ATOM 984  O OG    . SER A 1 139 ? 98.099  132.259 90.781  1.00 75.39  ? 139 SER A OG    1 
ATOM 985  N N     . LEU A 1 140 ? 101.581 131.896 89.571  1.00 67.36  ? 140 LEU A N     1 
ATOM 986  C CA    . LEU A 1 140 ? 102.706 131.899 90.488  1.00 63.57  ? 140 LEU A CA    1 
ATOM 987  C C     . LEU A 1 140 ? 102.611 133.056 91.476  1.00 64.42  ? 140 LEU A C     1 
ATOM 988  O O     . LEU A 1 140 ? 103.363 133.098 92.459  1.00 65.68  ? 140 LEU A O     1 
ATOM 989  C CB    . LEU A 1 140 ? 104.006 131.982 89.690  1.00 64.31  ? 140 LEU A CB    1 
ATOM 990  C CG    . LEU A 1 140 ? 105.191 131.173 90.199  1.00 62.92  ? 140 LEU A CG    1 
ATOM 991  C CD1   . LEU A 1 140 ? 104.756 129.725 90.227  1.00 68.23  ? 140 LEU A CD1   1 
ATOM 992  C CD2   . LEU A 1 140 ? 106.423 131.333 89.347  1.00 63.82  ? 140 LEU A CD2   1 
ATOM 993  N N     . GLN A 1 141 ? 101.675 133.983 91.242  1.00 70.67  ? 141 GLN A N     1 
ATOM 994  C CA    . GLN A 1 141 ? 101.458 135.094 92.161  1.00 73.00  ? 141 GLN A CA    1 
ATOM 995  C C     . GLN A 1 141 ? 100.843 134.628 93.474  1.00 73.07  ? 141 GLN A C     1 
ATOM 996  O O     . GLN A 1 141 ? 100.958 135.324 94.489  1.00 72.25  ? 141 GLN A O     1 
ATOM 997  C CB    . GLN A 1 141 ? 100.571 136.152 91.501  1.00 71.34  ? 141 GLN A CB    1 
ATOM 998  C CG    . GLN A 1 141 ? 101.008 136.551 90.098  1.00 73.90  ? 141 GLN A CG    1 
ATOM 999  C CD    . GLN A 1 141 ? 102.478 136.920 90.021  1.00 76.66  ? 141 GLN A CD    1 
ATOM 1000 O OE1   . GLN A 1 141 ? 103.247 136.305 89.283  1.00 78.55  ? 141 GLN A OE1   1 
ATOM 1001 N NE2   . GLN A 1 141 ? 102.873 137.933 90.783  1.00 73.54  ? 141 GLN A NE2   1 
ATOM 1002 N N     . ALA A 1 142 ? 100.201 133.456 93.477  1.00 67.34  ? 142 ALA A N     1 
ATOM 1003 C CA    . ALA A 1 142 ? 99.720  132.860 94.719  1.00 63.77  ? 142 ALA A CA    1 
ATOM 1004 C C     . ALA A 1 142 ? 100.879 132.503 95.645  1.00 66.18  ? 142 ALA A C     1 
ATOM 1005 O O     . ALA A 1 142 ? 100.867 132.854 96.832  1.00 67.42  ? 142 ALA A O     1 
ATOM 1006 C CB    . ALA A 1 142 ? 98.871  131.628 94.412  1.00 66.74  ? 142 ALA A CB    1 
ATOM 1007 N N     . LEU A 1 143 ? 101.925 131.856 95.111  1.00 72.98  ? 143 LEU A N     1 
ATOM 1008 C CA    . LEU A 1 143 ? 103.095 131.598 95.946  1.00 68.98  ? 143 LEU A CA    1 
ATOM 1009 C C     . LEU A 1 143 ? 103.896 132.864 96.207  1.00 64.98  ? 143 LEU A C     1 
ATOM 1010 O O     . LEU A 1 143 ? 104.629 132.913 97.200  1.00 63.21  ? 143 LEU A O     1 
ATOM 1011 C CB    . LEU A 1 143 ? 104.007 130.510 95.350  1.00 65.99  ? 143 LEU A CB    1 
ATOM 1012 C CG    . LEU A 1 143 ? 104.747 130.462 93.997  1.00 71.19  ? 143 LEU A CG    1 
ATOM 1013 C CD1   . LEU A 1 143 ? 105.887 131.472 93.814  1.00 71.02  ? 143 LEU A CD1   1 
ATOM 1014 C CD2   . LEU A 1 143 ? 105.301 129.060 93.796  1.00 70.29  ? 143 LEU A CD2   1 
ATOM 1015 N N     . HIS A 1 144 ? 103.802 133.862 95.317  1.00 66.27  ? 144 HIS A N     1 
ATOM 1016 C CA    . HIS A 1 144 ? 104.448 135.150 95.570  1.00 70.68  ? 144 HIS A CA    1 
ATOM 1017 C C     . HIS A 1 144 ? 103.840 135.837 96.791  1.00 70.85  ? 144 HIS A C     1 
ATOM 1018 O O     . HIS A 1 144 ? 104.557 136.325 97.679  1.00 69.27  ? 144 HIS A O     1 
ATOM 1019 C CB    . HIS A 1 144 ? 104.351 136.036 94.331  1.00 68.35  ? 144 HIS A CB    1 
ATOM 1020 C CG    . HIS A 1 144 ? 105.227 135.580 93.207  1.00 66.17  ? 144 HIS A CG    1 
ATOM 1021 N ND1   . HIS A 1 144 ? 106.413 134.911 93.419  1.00 66.36  ? 144 HIS A ND1   1 
ATOM 1022 C CD2   . HIS A 1 144 ? 105.082 135.675 91.865  1.00 70.57  ? 144 HIS A CD2   1 
ATOM 1023 C CE1   . HIS A 1 144 ? 106.966 134.621 92.255  1.00 69.30  ? 144 HIS A CE1   1 
ATOM 1024 N NE2   . HIS A 1 144 ? 106.178 135.073 91.296  1.00 71.74  ? 144 HIS A NE2   1 
ATOM 1025 N N     . ASP A 1 145 ? 102.511 135.826 96.877  1.00 70.92  ? 145 ASP A N     1 
ATOM 1026 C CA    . ASP A 1 145 ? 101.830 136.324 98.064  1.00 69.91  ? 145 ASP A CA    1 
ATOM 1027 C C     . ASP A 1 145 ? 102.039 135.405 99.264  1.00 69.77  ? 145 ASP A C     1 
ATOM 1028 O O     . ASP A 1 145 ? 101.909 135.841 100.414 1.00 68.33  ? 145 ASP A O     1 
ATOM 1029 C CB    . ASP A 1 145 ? 100.342 136.494 97.767  1.00 71.89  ? 145 ASP A CB    1 
ATOM 1030 C CG    . ASP A 1 145 ? 100.082 137.486 96.657  1.00 72.54  ? 145 ASP A CG    1 
ATOM 1031 O OD1   . ASP A 1 145 ? 100.895 138.419 96.494  1.00 73.51  ? 145 ASP A OD1   1 
ATOM 1032 O OD2   . ASP A 1 145 ? 99.064  137.338 95.949  1.00 72.21  ? 145 ASP A OD2   1 
ATOM 1033 N N     . ALA A 1 146 ? 102.334 134.124 99.019  1.00 68.21  ? 146 ALA A N     1 
ATOM 1034 C CA    . ALA A 1 146 ? 102.607 133.208 100.123 1.00 61.25  ? 146 ALA A CA    1 
ATOM 1035 C C     . ALA A 1 146 ? 103.947 133.504 100.789 1.00 62.88  ? 146 ALA A C     1 
ATOM 1036 O O     . ALA A 1 146 ? 104.025 133.581 102.021 1.00 58.72  ? 146 ALA A O     1 
ATOM 1037 C CB    . ALA A 1 146 ? 102.566 131.762 99.639  1.00 62.37  ? 146 ALA A CB    1 
ATOM 1038 N N     . LEU A 1 147 ? 105.026 133.658 100.005 1.00 70.41  ? 147 LEU A N     1 
ATOM 1039 C CA    . LEU A 1 147 ? 106.295 133.869 100.699 1.00 67.34  ? 147 LEU A CA    1 
ATOM 1040 C C     . LEU A 1 147 ? 106.485 135.330 101.070 1.00 67.75  ? 147 LEU A C     1 
ATOM 1041 O O     . LEU A 1 147 ? 107.339 135.640 101.908 1.00 69.75  ? 147 LEU A O     1 
ATOM 1042 C CB    . LEU A 1 147 ? 107.535 133.460 99.905  1.00 65.82  ? 147 LEU A CB    1 
ATOM 1043 C CG    . LEU A 1 147 ? 108.183 134.373 98.866  1.00 66.84  ? 147 LEU A CG    1 
ATOM 1044 C CD1   . LEU A 1 147 ? 109.454 133.732 98.437  1.00 71.24  ? 147 LEU A CD1   1 
ATOM 1045 C CD2   . LEU A 1 147 ? 107.378 134.622 97.675  1.00 67.68  ? 147 LEU A CD2   1 
ATOM 1046 N N     . SER A 1 148 ? 105.716 136.242 100.457 1.00 71.63  ? 148 SER A N     1 
ATOM 1047 C CA    . SER A 1 148 ? 105.821 137.647 100.837 1.00 73.56  ? 148 SER A CA    1 
ATOM 1048 C C     . SER A 1 148 ? 105.245 137.918 102.222 1.00 71.40  ? 148 SER A C     1 
ATOM 1049 O O     . SER A 1 148 ? 105.530 138.970 102.802 1.00 65.35  ? 148 SER A O     1 
ATOM 1050 C CB    . SER A 1 148 ? 105.128 138.532 99.799  1.00 73.48  ? 148 SER A CB    1 
ATOM 1051 O OG    . SER A 1 148 ? 105.677 139.840 99.797  1.00 71.21  ? 148 SER A OG    1 
ATOM 1052 N N     . GLY A 1 149 ? 104.452 136.994 102.766 1.00 66.21  ? 149 GLY A N     1 
ATOM 1053 C CA    . GLY A 1 149 ? 103.884 137.123 104.088 1.00 64.22  ? 149 GLY A CA    1 
ATOM 1054 C C     . GLY A 1 149 ? 102.444 137.579 104.117 1.00 63.43  ? 149 GLY A C     1 
ATOM 1055 O O     . GLY A 1 149 ? 101.840 137.596 105.196 1.00 61.27  ? 149 GLY A O     1 
ATOM 1056 N N     . ARG A 1 150 ? 101.874 137.941 102.973 1.00 68.18  ? 150 ARG A N     1 
ATOM 1057 C CA    . ARG A 1 150 ? 100.519 138.465 102.912 1.00 69.21  ? 150 ARG A CA    1 
ATOM 1058 C C     . ARG A 1 150 ? 99.474  137.383 102.675 1.00 70.77  ? 150 ARG A C     1 
ATOM 1059 O O     . ARG A 1 150 ? 98.284  137.700 102.585 1.00 71.15  ? 150 ARG A O     1 
ATOM 1060 C CB    . ARG A 1 150 ? 100.429 139.535 101.823 1.00 69.21  ? 150 ARG A CB    1 
ATOM 1061 C CG    . ARG A 1 150 ? 100.666 138.998 100.437 1.00 67.73  ? 150 ARG A CG    1 
ATOM 1062 C CD    . ARG A 1 150 ? 101.608 139.883 99.641  1.00 69.23  ? 150 ARG A CD    1 
ATOM 1063 N NE    . ARG A 1 150 ? 100.980 141.122 99.203  1.00 72.53  ? 150 ARG A NE    1 
ATOM 1064 C CZ    . ARG A 1 150 ? 101.605 142.072 98.521  1.00 71.38  ? 150 ARG A CZ    1 
ATOM 1065 N NH1   . ARG A 1 150 ? 102.874 141.947 98.168  1.00 69.61  ? 150 ARG A NH1   1 
ATOM 1066 N NH2   . ARG A 1 150 ? 100.940 143.173 98.183  1.00 68.70  ? 150 ARG A NH2   1 
ATOM 1067 N N     . LEU A 1 151 ? 99.888  136.122 102.565 1.00 70.27  ? 151 LEU A N     1 
ATOM 1068 C CA    . LEU A 1 151 ? 98.969  134.998 102.547 1.00 70.14  ? 151 LEU A CA    1 
ATOM 1069 C C     . LEU A 1 151 ? 99.223  134.115 103.764 1.00 65.65  ? 151 LEU A C     1 
ATOM 1070 O O     . LEU A 1 151 ? 100.375 133.942 104.170 1.00 68.24  ? 151 LEU A O     1 
ATOM 1071 C CB    . LEU A 1 151 ? 99.119  134.161 101.270 1.00 65.58  ? 151 LEU A CB    1 
ATOM 1072 C CG    . LEU A 1 151 ? 98.212  134.497 100.081 1.00 66.84  ? 151 LEU A CG    1 
ATOM 1073 C CD1   . LEU A 1 151 ? 98.179  133.334 99.100  1.00 65.43  ? 151 LEU A CD1   1 
ATOM 1074 C CD2   . LEU A 1 151 ? 96.801  134.882 100.511 1.00 69.57  ? 151 LEU A CD2   1 
ATOM 1075 N N     . PRO A 1 152 ? 98.169  133.554 104.379 1.00 56.45  ? 152 PRO A N     1 
ATOM 1076 C CA    . PRO A 1 152 ? 98.367  132.774 105.610 1.00 59.16  ? 152 PRO A CA    1 
ATOM 1077 C C     . PRO A 1 152 ? 99.009  131.412 105.390 1.00 57.54  ? 152 PRO A C     1 
ATOM 1078 O O     . PRO A 1 152 ? 99.780  130.954 106.238 1.00 59.86  ? 152 PRO A O     1 
ATOM 1079 C CB    . PRO A 1 152 ? 96.945  132.626 106.167 1.00 62.49  ? 152 PRO A CB    1 
ATOM 1080 C CG    . PRO A 1 152 ? 96.050  132.816 104.997 1.00 60.92  ? 152 PRO A CG    1 
ATOM 1081 C CD    . PRO A 1 152 ? 96.741  133.785 104.096 1.00 57.79  ? 152 PRO A CD    1 
ATOM 1082 N N     . SER A 1 153 ? 98.705  130.748 104.278 1.00 62.64  ? 153 SER A N     1 
ATOM 1083 C CA    . SER A 1 153 ? 99.175  129.389 104.053 1.00 64.70  ? 153 SER A CA    1 
ATOM 1084 C C     . SER A 1 153 ? 99.811  129.259 102.678 1.00 63.88  ? 153 SER A C     1 
ATOM 1085 O O     . SER A 1 153 ? 99.327  129.833 101.698 1.00 68.18  ? 153 SER A O     1 
ATOM 1086 C CB    . SER A 1 153 ? 98.034  128.377 104.201 1.00 67.20  ? 153 SER A CB    1 
ATOM 1087 O OG    . SER A 1 153 ? 98.000  127.843 105.515 1.00 68.04  ? 153 SER A OG    1 
ATOM 1088 N N     . VAL A 1 154 ? 100.896 128.492 102.624 1.00 49.29  ? 154 VAL A N     1 
ATOM 1089 C CA    . VAL A 1 154 ? 101.648 128.220 101.401 1.00 49.23  ? 154 VAL A CA    1 
ATOM 1090 C C     . VAL A 1 154 ? 100.969 127.093 100.630 1.00 50.81  ? 154 VAL A C     1 
ATOM 1091 O O     . VAL A 1 154 ? 100.717 126.023 101.203 1.00 53.93  ? 154 VAL A O     1 
ATOM 1092 C CB    . VAL A 1 154 ? 103.107 127.865 101.727 1.00 48.55  ? 154 VAL A CB    1 
ATOM 1093 C CG1   . VAL A 1 154 ? 103.896 127.617 100.453 1.00 49.04  ? 154 VAL A CG1   1 
ATOM 1094 C CG2   . VAL A 1 154 ? 103.741 128.964 102.557 1.00 49.71  ? 154 VAL A CG2   1 
ATOM 1095 N N     . PRO A 1 155 ? 100.635 127.286 99.353  1.00 57.39  ? 155 PRO A N     1 
ATOM 1096 C CA    . PRO A 1 155 ? 100.044 126.190 98.573  1.00 61.10  ? 155 PRO A CA    1 
ATOM 1097 C C     . PRO A 1 155 ? 101.078 125.124 98.242  1.00 64.12  ? 155 PRO A C     1 
ATOM 1098 O O     . PRO A 1 155 ? 102.260 125.416 98.050  1.00 65.41  ? 155 PRO A O     1 
ATOM 1099 C CB    . PRO A 1 155 ? 99.530  126.886 97.306  1.00 58.93  ? 155 PRO A CB    1 
ATOM 1100 C CG    . PRO A 1 155 ? 99.616  128.364 97.582  1.00 56.83  ? 155 PRO A CG    1 
ATOM 1101 C CD    . PRO A 1 155 ? 100.705 128.537 98.584  1.00 58.65  ? 155 PRO A CD    1 
ATOM 1102 N N     . PHE A 1 156 ? 100.618 123.874 98.164  1.00 69.53  ? 156 PHE A N     1 
ATOM 1103 C CA    . PHE A 1 156 ? 101.522 122.755 97.922  1.00 67.54  ? 156 PHE A CA    1 
ATOM 1104 C C     . PHE A 1 156 ? 101.528 122.288 96.474  1.00 67.94  ? 156 PHE A C     1 
ATOM 1105 O O     . PHE A 1 156 ? 102.502 121.657 96.045  1.00 70.11  ? 156 PHE A O     1 
ATOM 1106 C CB    . PHE A 1 156 ? 101.170 121.567 98.822  1.00 68.44  ? 156 PHE A CB    1 
ATOM 1107 C CG    . PHE A 1 156 ? 102.356 120.713 99.177  1.00 69.65  ? 156 PHE A CG    1 
ATOM 1108 C CD1   . PHE A 1 156 ? 103.243 121.111 100.167 1.00 70.21  ? 156 PHE A CD1   1 
ATOM 1109 C CD2   . PHE A 1 156 ? 102.602 119.529 98.494  1.00 69.66  ? 156 PHE A CD2   1 
ATOM 1110 C CE1   . PHE A 1 156 ? 104.344 120.333 100.484 1.00 69.84  ? 156 PHE A CE1   1 
ATOM 1111 C CE2   . PHE A 1 156 ? 103.701 118.747 98.805  1.00 67.55  ? 156 PHE A CE2   1 
ATOM 1112 C CZ    . PHE A 1 156 ? 104.571 119.149 99.801  1.00 68.55  ? 156 PHE A CZ    1 
ATOM 1113 N N     . GLU A 1 157 ? 100.460 122.563 95.722  1.00 76.34  ? 157 GLU A N     1 
ATOM 1114 C CA    . GLU A 1 157 ? 100.433 122.210 94.306  1.00 80.98  ? 157 GLU A CA    1 
ATOM 1115 C C     . GLU A 1 157 ? 101.456 123.028 93.529  1.00 75.80  ? 157 GLU A C     1 
ATOM 1116 O O     . GLU A 1 157 ? 102.205 122.495 92.701  1.00 78.30  ? 157 GLU A O     1 
ATOM 1117 C CB    . GLU A 1 157 ? 99.026  122.426 93.749  1.00 82.33  ? 157 GLU A CB    1 
ATOM 1118 C CG    . GLU A 1 157 ? 98.866  122.104 92.275  1.00 81.33  ? 157 GLU A CG    1 
ATOM 1119 C CD    . GLU A 1 157 ? 98.889  123.340 91.406  1.00 79.43  ? 157 GLU A CD    1 
ATOM 1120 O OE1   . GLU A 1 157 ? 98.815  124.455 91.963  1.00 78.21  ? 157 GLU A OE1   1 
ATOM 1121 O OE2   . GLU A 1 157 ? 98.975  123.193 90.171  1.00 75.73  ? 157 GLU A OE2   1 
ATOM 1122 N N     . THR A 1 158 ? 101.531 124.324 93.824  1.00 62.87  ? 158 THR A N     1 
ATOM 1123 C CA    . THR A 1 158 ? 102.526 125.187 93.205  1.00 72.33  ? 158 THR A CA    1 
ATOM 1124 C C     . THR A 1 158 ? 103.940 124.933 93.735  1.00 69.28  ? 158 THR A C     1 
ATOM 1125 O O     . THR A 1 158 ? 104.913 125.120 92.991  1.00 64.04  ? 158 THR A O     1 
ATOM 1126 C CB    . THR A 1 158 ? 102.077 126.649 93.356  1.00 73.34  ? 158 THR A CB    1 
ATOM 1127 O OG1   . THR A 1 158 ? 102.684 127.465 92.344  1.00 65.72  ? 158 THR A OG1   1 
ATOM 1128 C CG2   . THR A 1 158 ? 102.290 127.208 94.764  1.00 72.25  ? 158 THR A CG2   1 
ATOM 1129 N N     . ILE A 1 159 ? 104.086 124.420 94.963  1.00 63.50  ? 159 ILE A N     1 
ATOM 1130 C CA    . ILE A 1 159 ? 105.421 124.068 95.435  1.00 59.54  ? 159 ILE A CA    1 
ATOM 1131 C C     . ILE A 1 159 ? 105.869 122.756 94.804  1.00 57.16  ? 159 ILE A C     1 
ATOM 1132 O O     . ILE A 1 159 ? 107.061 122.552 94.554  1.00 63.30  ? 159 ILE A O     1 
ATOM 1133 C CB    . ILE A 1 159 ? 105.478 124.045 96.980  1.00 60.46  ? 159 ILE A CB    1 
ATOM 1134 C CG1   . ILE A 1 159 ? 106.845 124.493 97.460  1.00 58.90  ? 159 ILE A CG1   1 
ATOM 1135 C CG2   . ILE A 1 159 ? 105.264 122.672 97.596  1.00 54.51  ? 159 ILE A CG2   1 
ATOM 1136 C CD1   . ILE A 1 159 ? 106.828 124.931 98.880  1.00 55.14  ? 159 ILE A CD1   1 
ATOM 1137 N N     . GLN A 1 160 ? 104.917 121.885 94.446  1.00 55.57  ? 160 GLN A N     1 
ATOM 1138 C CA    . GLN A 1 160 ? 105.285 120.666 93.742  1.00 57.80  ? 160 GLN A CA    1 
ATOM 1139 C C     . GLN A 1 160 ? 105.579 120.957 92.283  1.00 54.29  ? 160 GLN A C     1 
ATOM 1140 O O     . GLN A 1 160 ? 106.424 120.294 91.678  1.00 54.90  ? 160 GLN A O     1 
ATOM 1141 C CB    . GLN A 1 160 ? 104.183 119.612 93.871  1.00 61.83  ? 160 GLN A CB    1 
ATOM 1142 C CG    . GLN A 1 160 ? 104.549 118.148 93.482  1.00 57.69  ? 160 GLN A CG    1 
ATOM 1143 C CD    . GLN A 1 160 ? 105.595 117.406 94.349  1.00 60.43  ? 160 GLN A CD    1 
ATOM 1144 O OE1   . GLN A 1 160 ? 106.376 117.984 95.107  1.00 60.26  ? 160 GLN A OE1   1 
ATOM 1145 N NE2   . GLN A 1 160 ? 105.598 116.087 94.211  1.00 58.83  ? 160 GLN A NE2   1 
ATOM 1146 N N     . ALA A 1 161 ? 104.903 121.958 91.712  1.00 53.44  ? 161 ALA A N     1 
ATOM 1147 C CA    . ALA A 1 161 ? 105.238 122.414 90.367  1.00 55.77  ? 161 ALA A CA    1 
ATOM 1148 C C     . ALA A 1 161 ? 106.634 123.024 90.320  1.00 49.97  ? 161 ALA A C     1 
ATOM 1149 O O     . ALA A 1 161 ? 107.397 122.760 89.385  1.00 56.97  ? 161 ALA A O     1 
ATOM 1150 C CB    . ALA A 1 161 ? 104.195 123.415 89.874  1.00 57.62  ? 161 ALA A CB    1 
ATOM 1151 N N     . LEU A 1 162 ? 106.994 123.822 91.331  1.00 51.71  ? 162 LEU A N     1 
ATOM 1152 C CA    . LEU A 1 162 ? 108.346 124.379 91.391  1.00 53.28  ? 162 LEU A CA    1 
ATOM 1153 C C     . LEU A 1 162 ? 109.386 123.291 91.657  1.00 49.26  ? 162 LEU A C     1 
ATOM 1154 O O     . LEU A 1 162 ? 110.532 123.392 91.201  1.00 45.29  ? 162 LEU A O     1 
ATOM 1155 C CB    . LEU A 1 162 ? 108.412 125.476 92.458  1.00 52.31  ? 162 LEU A CB    1 
ATOM 1156 C CG    . LEU A 1 162 ? 109.726 126.236 92.659  1.00 51.60  ? 162 LEU A CG    1 
ATOM 1157 C CD1   . LEU A 1 162 ? 110.131 126.925 91.374  1.00 47.89  ? 162 LEU A CD1   1 
ATOM 1158 C CD2   . LEU A 1 162 ? 109.607 127.242 93.782  1.00 56.09  ? 162 LEU A CD2   1 
ATOM 1159 N N     . ASP A 1 163 ? 109.000 122.244 92.394  1.00 47.48  ? 163 ASP A N     1 
ATOM 1160 C CA    . ASP A 1 163 ? 109.857 121.074 92.554  1.00 36.07  ? 163 ASP A CA    1 
ATOM 1161 C C     . ASP A 1 163 ? 110.076 120.358 91.230  1.00 45.12  ? 163 ASP A C     1 
ATOM 1162 O O     . ASP A 1 163 ? 111.196 119.941 90.917  1.00 54.51  ? 163 ASP A O     1 
ATOM 1163 C CB    . ASP A 1 163 ? 109.236 120.111 93.566  1.00 48.99  ? 163 ASP A CB    1 
ATOM 1164 C CG    . ASP A 1 163 ? 110.203 119.038 94.029  1.00 48.87  ? 163 ASP A CG    1 
ATOM 1165 O OD1   . ASP A 1 163 ? 111.415 119.144 93.753  1.00 45.62  ? 163 ASP A OD1   1 
ATOM 1166 O OD2   . ASP A 1 163 ? 109.740 118.074 94.670  1.00 45.35  ? 163 ASP A OD2   1 
ATOM 1167 N N     . VAL A 1 164 ? 109.012 120.195 90.441  1.00 58.55  ? 164 VAL A N     1 
ATOM 1168 C CA    . VAL A 1 164 ? 109.104 119.278 89.312  1.00 52.77  ? 164 VAL A CA    1 
ATOM 1169 C C     . VAL A 1 164 ? 109.499 120.026 88.044  1.00 53.71  ? 164 VAL A C     1 
ATOM 1170 O O     . VAL A 1 164 ? 109.707 119.413 86.993  1.00 60.98  ? 164 VAL A O     1 
ATOM 1171 C CB    . VAL A 1 164 ? 107.797 118.476 89.166  1.00 44.68  ? 164 VAL A CB    1 
ATOM 1172 C CG1   . VAL A 1 164 ? 106.768 119.303 88.585  1.00 42.02  ? 164 VAL A CG1   1 
ATOM 1173 C CG2   . VAL A 1 164 ? 107.976 117.136 88.439  1.00 51.80  ? 164 VAL A CG2   1 
ATOM 1174 N N     . VAL A 1 165 ? 109.624 121.356 88.123  1.00 51.50  ? 165 VAL A N     1 
ATOM 1175 C CA    . VAL A 1 165 ? 110.417 122.113 87.149  1.00 43.15  ? 165 VAL A CA    1 
ATOM 1176 C C     . VAL A 1 165 ? 111.841 121.577 87.070  1.00 42.15  ? 165 VAL A C     1 
ATOM 1177 O O     . VAL A 1 165 ? 112.405 121.420 85.979  1.00 55.35  ? 165 VAL A O     1 
ATOM 1178 C CB    . VAL A 1 165 ? 110.379 123.620 87.508  1.00 52.59  ? 165 VAL A CB    1 
ATOM 1179 C CG1   . VAL A 1 165 ? 111.515 124.395 86.860  1.00 56.13  ? 165 VAL A CG1   1 
ATOM 1180 C CG2   . VAL A 1 165 ? 109.077 124.232 87.027  1.00 52.84  ? 165 VAL A CG2   1 
ATOM 1181 N N     . MET A 1 166 ? 112.414 121.216 88.208  1.00 38.13  ? 166 MET A N     1 
ATOM 1182 C CA    . MET A 1 166 ? 113.820 120.872 88.294  1.00 47.06  ? 166 MET A CA    1 
ATOM 1183 C C     . MET A 1 166 ? 114.003 119.347 88.417  1.00 45.60  ? 166 MET A C     1 
ATOM 1184 O O     . MET A 1 166 ? 115.108 118.852 88.656  1.00 49.24  ? 166 MET A O     1 
ATOM 1185 C CB    . MET A 1 166 ? 114.382 121.757 89.424  1.00 53.39  ? 166 MET A CB    1 
ATOM 1186 C CG    . MET A 1 166 ? 115.430 121.393 90.448  1.00 48.82  ? 166 MET A CG    1 
ATOM 1187 S SD    . MET A 1 166 ? 115.793 122.979 91.209  1.00 38.66  ? 166 MET A SD    1 
ATOM 1188 C CE    . MET A 1 166 ? 117.107 123.590 90.190  1.00 48.26  ? 166 MET A CE    1 
ATOM 1189 N N     . ARG A 1 167 ? 112.949 118.581 88.112  1.00 52.88  ? 167 ARG A N     1 
ATOM 1190 C CA    . ARG A 1 167 ? 112.998 117.118 88.058  1.00 55.50  ? 167 ARG A CA    1 
ATOM 1191 C C     . ARG A 1 167 ? 113.287 116.539 86.677  1.00 55.38  ? 167 ARG A C     1 
ATOM 1192 O O     . ARG A 1 167 ? 114.032 115.567 86.579  1.00 55.77  ? 167 ARG A O     1 
ATOM 1193 C CB    . ARG A 1 167 ? 111.675 116.505 88.530  1.00 50.27  ? 167 ARG A CB    1 
ATOM 1194 C CG    . ARG A 1 167 ? 111.349 116.580 90.001  1.00 47.15  ? 167 ARG A CG    1 
ATOM 1195 C CD    . ARG A 1 167 ? 112.386 116.178 90.957  1.00 51.16  ? 167 ARG A CD    1 
ATOM 1196 N NE    . ARG A 1 167 ? 111.835 116.317 92.296  1.00 51.68  ? 167 ARG A NE    1 
ATOM 1197 C CZ    . ARG A 1 167 ? 111.668 115.313 93.140  1.00 52.97  ? 167 ARG A CZ    1 
ATOM 1198 N NH1   . ARG A 1 167 ? 111.950 114.070 92.793  1.00 54.94  ? 167 ARG A NH1   1 
ATOM 1199 N NH2   . ARG A 1 167 ? 111.186 115.562 94.353  1.00 53.08  ? 167 ARG A NH2   1 
ATOM 1200 N N     . HIS A 1 168 ? 112.696 117.081 85.607  1.00 68.21  ? 168 HIS A N     1 
ATOM 1201 C CA    . HIS A 1 168 ? 112.534 116.307 84.375  1.00 72.04  ? 168 HIS A CA    1 
ATOM 1202 C C     . HIS A 1 168 ? 113.831 116.202 83.572  1.00 75.74  ? 168 HIS A C     1 
ATOM 1203 O O     . HIS A 1 168 ? 114.114 115.157 82.975  1.00 81.45  ? 168 HIS A O     1 
ATOM 1204 C CB    . HIS A 1 168 ? 111.409 116.912 83.540  1.00 73.75  ? 168 HIS A CB    1 
ATOM 1205 C CG    . HIS A 1 168 ? 111.414 116.506 82.100  1.00 83.49  ? 168 HIS A CG    1 
ATOM 1206 N ND1   . HIS A 1 168 ? 111.491 117.423 81.074  1.00 79.10  ? 168 HIS A ND1   1 
ATOM 1207 C CD2   . HIS A 1 168 ? 111.318 115.290 81.512  1.00 82.12  ? 168 HIS A CD2   1 
ATOM 1208 C CE1   . HIS A 1 168 ? 111.461 116.788 79.916  1.00 74.87  ? 168 HIS A CE1   1 
ATOM 1209 N NE2   . HIS A 1 168 ? 111.357 115.493 80.153  1.00 76.86  ? 168 HIS A NE2   1 
ATOM 1210 N N     . LEU A 1 169 ? 114.622 117.274 83.518  1.00 70.51  ? 169 LEU A N     1 
ATOM 1211 C CA    . LEU A 1 169 ? 115.975 117.134 82.973  1.00 73.80  ? 169 LEU A CA    1 
ATOM 1212 C C     . LEU A 1 169 ? 116.877 116.264 83.852  1.00 76.11  ? 169 LEU A C     1 
ATOM 1213 O O     . LEU A 1 169 ? 117.643 115.464 83.287  1.00 74.57  ? 169 LEU A O     1 
ATOM 1214 C CB    . LEU A 1 169 ? 116.573 118.517 82.652  1.00 72.55  ? 169 LEU A CB    1 
ATOM 1215 C CG    . LEU A 1 169 ? 117.780 118.697 81.706  1.00 74.95  ? 169 LEU A CG    1 
ATOM 1216 C CD1   . LEU A 1 169 ? 119.147 118.314 82.276  1.00 74.60  ? 169 LEU A CD1   1 
ATOM 1217 C CD2   . LEU A 1 169 ? 117.558 117.867 80.474  1.00 75.71  ? 169 LEU A CD2   1 
ATOM 1218 N N     . PRO A 1 170 ? 116.858 116.336 85.193  1.00 72.19  ? 170 PRO A N     1 
ATOM 1219 C CA    . PRO A 1 170 ? 117.551 115.283 85.949  1.00 68.92  ? 170 PRO A CA    1 
ATOM 1220 C C     . PRO A 1 170 ? 116.809 113.957 86.022  1.00 71.15  ? 170 PRO A C     1 
ATOM 1221 O O     . PRO A 1 170 ? 117.352 113.015 86.607  1.00 71.02  ? 170 PRO A O     1 
ATOM 1222 C CB    . PRO A 1 170 ? 117.728 115.903 87.341  1.00 68.45  ? 170 PRO A CB    1 
ATOM 1223 C CG    . PRO A 1 170 ? 117.619 117.316 87.144  1.00 73.67  ? 170 PRO A CG    1 
ATOM 1224 C CD    . PRO A 1 170 ? 116.621 117.495 86.078  1.00 71.88  ? 170 PRO A CD    1 
ATOM 1225 N N     . SER A 1 171 ? 115.606 113.839 85.448  1.00 82.50  ? 171 SER A N     1 
ATOM 1226 C CA    . SER A 1 171 ? 114.924 112.545 85.418  1.00 80.79  ? 171 SER A CA    1 
ATOM 1227 C C     . SER A 1 171 ? 115.573 111.590 84.424  1.00 81.81  ? 171 SER A C     1 
ATOM 1228 O O     . SER A 1 171 ? 115.539 110.369 84.617  1.00 81.83  ? 171 SER A O     1 
ATOM 1229 C CB    . SER A 1 171 ? 113.444 112.722 85.081  1.00 77.73  ? 171 SER A CB    1 
ATOM 1230 O OG    . SER A 1 171 ? 112.769 113.408 86.121  1.00 74.25  ? 171 SER A OG    1 
ATOM 1231 N N     . MET A 1 172 ? 116.130 112.121 83.334  1.00 81.34  ? 172 MET A N     1 
ATOM 1232 C CA    . MET A 1 172 ? 116.812 111.273 82.362  1.00 82.61  ? 172 MET A CA    1 
ATOM 1233 C C     . MET A 1 172 ? 118.119 110.754 82.938  1.00 81.57  ? 172 MET A C     1 
ATOM 1234 O O     . MET A 1 172 ? 118.440 109.565 82.827  1.00 82.64  ? 172 MET A O     1 
ATOM 1235 C CB    . MET A 1 172 ? 117.064 112.059 81.073  1.00 81.80  ? 172 MET A CB    1 
ATOM 1236 C CG    . MET A 1 172 ? 117.951 111.378 80.021  1.00 78.29  ? 172 MET A CG    1 
ATOM 1237 S SD    . MET A 1 172 ? 117.584 109.641 79.680  1.00 79.61  ? 172 MET A SD    1 
ATOM 1238 C CE    . MET A 1 172 ? 118.549 109.381 78.194  1.00 80.43  ? 172 MET A CE    1 
ATOM 1239 N N     . ARG A 1 173 ? 118.880 111.637 83.576  1.00 84.63  ? 173 ARG A N     1 
ATOM 1240 C CA    . ARG A 1 173 ? 120.165 111.231 84.119  1.00 87.05  ? 173 ARG A CA    1 
ATOM 1241 C C     . ARG A 1 173 ? 120.018 110.456 85.422  1.00 90.58  ? 173 ARG A C     1 
ATOM 1242 O O     . ARG A 1 173 ? 120.796 109.526 85.673  1.00 90.63  ? 173 ARG A O     1 
ATOM 1243 C CB    . ARG A 1 173 ? 121.054 112.457 84.314  1.00 86.19  ? 173 ARG A CB    1 
ATOM 1244 C CG    . ARG A 1 173 ? 121.883 112.784 83.087  1.00 86.49  ? 173 ARG A CG    1 
ATOM 1245 C CD    . ARG A 1 173 ? 122.293 114.241 83.072  1.00 89.33  ? 173 ARG A CD    1 
ATOM 1246 N NE    . ARG A 1 173 ? 123.405 114.471 83.986  1.00 89.13  ? 173 ARG A NE    1 
ATOM 1247 C CZ    . ARG A 1 173 ? 123.309 115.115 85.140  1.00 85.78  ? 173 ARG A CZ    1 
ATOM 1248 N NH1   . ARG A 1 173 ? 122.167 115.646 85.542  1.00 86.74  ? 173 ARG A NH1   1 
ATOM 1249 N NH2   . ARG A 1 173 ? 124.387 115.226 85.909  1.00 85.77  ? 173 ARG A NH2   1 
ATOM 1250 N N     . TYR A 1 174 ? 119.040 110.804 86.256  1.00 90.28  ? 174 TYR A N     1 
ATOM 1251 C CA    . TYR A 1 174 ? 118.816 110.095 87.509  1.00 87.03  ? 174 TYR A CA    1 
ATOM 1252 C C     . TYR A 1 174 ? 117.380 109.593 87.509  1.00 87.01  ? 174 TYR A C     1 
ATOM 1253 O O     . TYR A 1 174 ? 116.451 110.389 87.366  1.00 84.87  ? 174 TYR A O     1 
ATOM 1254 C CB    . TYR A 1 174 ? 119.050 110.999 88.722  1.00 84.59  ? 174 TYR A CB    1 
ATOM 1255 C CG    . TYR A 1 174 ? 120.164 112.015 88.571  1.00 82.27  ? 174 TYR A CG    1 
ATOM 1256 C CD1   . TYR A 1 174 ? 121.494 111.633 88.512  1.00 84.77  ? 174 TYR A CD1   1 
ATOM 1257 C CD2   . TYR A 1 174 ? 119.877 113.370 88.575  1.00 82.14  ? 174 TYR A CD2   1 
ATOM 1258 C CE1   . TYR A 1 174 ? 122.509 112.573 88.399  1.00 90.54  ? 174 TYR A CE1   1 
ATOM 1259 C CE2   . TYR A 1 174 ? 120.876 114.319 88.467  1.00 88.01  ? 174 TYR A CE2   1 
ATOM 1260 C CZ    . TYR A 1 174 ? 122.192 113.912 88.379  1.00 91.26  ? 174 TYR A CZ    1 
ATOM 1261 O OH    . TYR A 1 174 ? 123.196 114.847 88.277  1.00 89.49  ? 174 TYR A OH    1 
ATOM 1262 N N     . THR A 1 175 ? 117.192 108.289 87.696  1.00 85.89  ? 175 THR A N     1 
ATOM 1263 C CA    . THR A 1 175 ? 115.862 107.695 87.601  1.00 84.69  ? 175 THR A CA    1 
ATOM 1264 C C     . THR A 1 175 ? 115.031 107.978 88.848  1.00 83.73  ? 175 THR A C     1 
ATOM 1265 O O     . THR A 1 175 ? 115.290 107.400 89.909  1.00 85.22  ? 175 THR A O     1 
ATOM 1266 C CB    . THR A 1 175 ? 115.973 106.188 87.371  1.00 86.24  ? 175 THR A CB    1 
ATOM 1267 O OG1   . THR A 1 175 ? 116.332 105.538 88.597  1.00 85.32  ? 175 THR A OG1   1 
ATOM 1268 C CG2   . THR A 1 175 ? 117.027 105.891 86.316  1.00 86.05  ? 175 THR A CG2   1 
ATOM 1269 N N     . PRO A 1 176 ? 114.003 108.817 88.755  1.00 81.12  ? 176 PRO A N     1 
ATOM 1270 C CA    . PRO A 1 176 ? 113.322 109.300 89.957  1.00 85.86  ? 176 PRO A CA    1 
ATOM 1271 C C     . PRO A 1 176 ? 112.186 108.406 90.424  1.00 85.75  ? 176 PRO A C     1 
ATOM 1272 O O     . PRO A 1 176 ? 111.260 108.075 89.683  1.00 83.95  ? 176 PRO A O     1 
ATOM 1273 C CB    . PRO A 1 176 ? 112.758 110.657 89.516  1.00 85.24  ? 176 PRO A CB    1 
ATOM 1274 C CG    . PRO A 1 176 ? 112.791 110.646 88.025  1.00 83.28  ? 176 PRO A CG    1 
ATOM 1275 C CD    . PRO A 1 176 ? 113.383 109.357 87.538  1.00 82.42  ? 176 PRO A CD    1 
ATOM 1276 N N     . VAL A 1 177 ? 112.273 108.020 91.694  1.00 84.45  ? 177 VAL A N     1 
ATOM 1277 C CA    . VAL A 1 177 ? 111.150 107.392 92.378  1.00 82.10  ? 177 VAL A CA    1 
ATOM 1278 C C     . VAL A 1 177 ? 110.827 108.225 93.612  1.00 79.14  ? 177 VAL A C     1 
ATOM 1279 O O     . VAL A 1 177 ? 111.690 108.935 94.141  1.00 77.81  ? 177 VAL A O     1 
ATOM 1280 C CB    . VAL A 1 177 ? 111.422 105.905 92.724  1.00 82.88  ? 177 VAL A CB    1 
ATOM 1281 C CG1   . VAL A 1 177 ? 112.098 105.177 91.561  1.00 83.36  ? 177 VAL A CG1   1 
ATOM 1282 C CG2   . VAL A 1 177 ? 112.242 105.755 93.994  1.00 81.48  ? 177 VAL A CG2   1 
ATOM 1283 N N     . GLY A 1 178 ? 109.566 108.162 94.033  1.00 80.23  ? 178 GLY A N     1 
ATOM 1284 C CA    . GLY A 1 178 ? 109.092 108.934 95.174  1.00 83.85  ? 178 GLY A CA    1 
ATOM 1285 C C     . GLY A 1 178 ? 109.158 110.425 94.905  1.00 81.20  ? 178 GLY A C     1 
ATOM 1286 O O     . GLY A 1 178 ? 108.598 110.938 93.929  1.00 80.47  ? 178 GLY A O     1 
ATOM 1287 N N     . ARG A 1 179 ? 109.870 111.132 95.777  1.00 70.57  ? 179 ARG A N     1 
ATOM 1288 C CA    . ARG A 1 179 ? 110.221 112.521 95.524  1.00 67.60  ? 179 ARG A CA    1 
ATOM 1289 C C     . ARG A 1 179 ? 111.731 112.670 95.625  1.00 66.58  ? 179 ARG A C     1 
ATOM 1290 O O     . ARG A 1 179 ? 112.232 113.674 96.137  1.00 71.65  ? 179 ARG A O     1 
ATOM 1291 C CB    . ARG A 1 179 ? 109.522 113.463 96.504  1.00 68.92  ? 179 ARG A CB    1 
ATOM 1292 C CG    . ARG A 1 179 ? 109.523 112.994 97.946  1.00 69.90  ? 179 ARG A CG    1 
ATOM 1293 C CD    . ARG A 1 179 ? 108.669 113.908 98.804  1.00 69.95  ? 179 ARG A CD    1 
ATOM 1294 N NE    . ARG A 1 179 ? 109.002 115.312 98.593  1.00 66.89  ? 179 ARG A NE    1 
ATOM 1295 C CZ    . ARG A 1 179 ? 108.128 116.306 98.663  1.00 68.97  ? 179 ARG A CZ    1 
ATOM 1296 N NH1   . ARG A 1 179 ? 106.853 116.086 98.939  1.00 66.71  ? 179 ARG A NH1   1 
ATOM 1297 N NH2   . ARG A 1 179 ? 108.543 117.552 98.451  1.00 71.55  ? 179 ARG A NH2   1 
ATOM 1298 N N     . SER A 1 180 ? 112.459 111.688 95.103  1.00 66.87  ? 180 SER A N     1 
ATOM 1299 C CA    . SER A 1 180 ? 113.905 111.624 95.221  1.00 69.10  ? 180 SER A CA    1 
ATOM 1300 C C     . SER A 1 180 ? 114.531 111.480 93.841  1.00 72.92  ? 180 SER A C     1 
ATOM 1301 O O     . SER A 1 180 ? 113.868 111.596 92.807  1.00 74.48  ? 180 SER A O     1 
ATOM 1302 C CB    . SER A 1 180 ? 114.339 110.462 96.126  1.00 68.06  ? 180 SER A CB    1 
ATOM 1303 O OG    . SER A 1 180 ? 115.708 110.146 95.950  1.00 69.63  ? 180 SER A OG    1 
ATOM 1304 N N     . PHE A 1 181 ? 115.839 111.264 93.847  1.00 74.81  ? 181 PHE A N     1 
ATOM 1305 C CA    . PHE A 1 181 ? 116.630 111.020 92.656  1.00 71.29  ? 181 PHE A CA    1 
ATOM 1306 C C     . PHE A 1 181 ? 117.625 109.916 92.957  1.00 73.65  ? 181 PHE A C     1 
ATOM 1307 O O     . PHE A 1 181 ? 118.071 109.758 94.092  1.00 81.23  ? 181 PHE A O     1 
ATOM 1308 C CB    . PHE A 1 181 ? 117.333 112.290 92.215  1.00 69.81  ? 181 PHE A CB    1 
ATOM 1309 C CG    . PHE A 1 181 ? 116.541 113.097 91.256  1.00 70.90  ? 181 PHE A CG    1 
ATOM 1310 C CD1   . PHE A 1 181 ? 115.840 112.475 90.246  1.00 74.50  ? 181 PHE A CD1   1 
ATOM 1311 C CD2   . PHE A 1 181 ? 116.565 114.476 91.303  1.00 71.34  ? 181 PHE A CD2   1 
ATOM 1312 C CE1   . PHE A 1 181 ? 115.142 113.217 89.331  1.00 76.95  ? 181 PHE A CE1   1 
ATOM 1313 C CE2   . PHE A 1 181 ? 115.852 115.216 90.402  1.00 72.00  ? 181 PHE A CE2   1 
ATOM 1314 C CZ    . PHE A 1 181 ? 115.143 114.576 89.414  1.00 77.38  ? 181 PHE A CZ    1 
ATOM 1315 N N     . PHE A 1 182 ? 117.942 109.128 91.932  1.00 87.06  ? 182 PHE A N     1 
ATOM 1316 C CA    . PHE A 1 182 ? 118.745 107.907 92.063  1.00 90.09  ? 182 PHE A CA    1 
ATOM 1317 C C     . PHE A 1 182 ? 119.881 108.068 91.053  1.00 94.84  ? 182 PHE A C     1 
ATOM 1318 O O     . PHE A 1 182 ? 119.663 107.885 89.853  1.00 97.62  ? 182 PHE A O     1 
ATOM 1319 C CB    . PHE A 1 182 ? 117.911 106.669 91.760  1.00 95.25  ? 182 PHE A CB    1 
ATOM 1320 C CG    . PHE A 1 182 ? 117.132 106.111 92.926  1.00 98.16  ? 182 PHE A CG    1 
ATOM 1321 C CD1   . PHE A 1 182 ? 116.908 106.841 94.078  1.00 93.31  ? 182 PHE A CD1   1 
ATOM 1322 C CD2   . PHE A 1 182 ? 116.562 104.850 92.825  1.00 99.63  ? 182 PHE A CD2   1 
ATOM 1323 C CE1   . PHE A 1 182 ? 116.168 106.326 95.115  1.00 93.68  ? 182 PHE A CE1   1 
ATOM 1324 C CE2   . PHE A 1 182 ? 115.821 104.318 93.864  1.00 98.31  ? 182 PHE A CE2   1 
ATOM 1325 C CZ    . PHE A 1 182 ? 115.622 105.061 95.011  1.00 96.54  ? 182 PHE A CZ    1 
ATOM 1326 N N     . THR A 1 183 ? 121.079 108.414 91.528  1.00 105.91 ? 183 THR A N     1 
ATOM 1327 C CA    . THR A 1 183 ? 122.124 108.855 90.608  1.00 106.23 ? 183 THR A CA    1 
ATOM 1328 C C     . THR A 1 183 ? 122.730 107.691 89.829  1.00 105.45 ? 183 THR A C     1 
ATOM 1329 O O     . THR A 1 183 ? 122.627 106.523 90.212  1.00 104.32 ? 183 THR A O     1 
ATOM 1330 C CB    . THR A 1 183 ? 123.231 109.635 91.336  1.00 105.91 ? 183 THR A CB    1 
ATOM 1331 O OG1   . THR A 1 183 ? 123.886 110.499 90.404  1.00 104.13 ? 183 THR A OG1   1 
ATOM 1332 C CG2   . THR A 1 183 ? 124.300 108.713 91.920  1.00 105.34 ? 183 THR A CG2   1 
ATOM 1333 N N     . ALA A 1 184 ? 123.325 108.023 88.692  1.00 107.72 ? 184 ALA A N     1 
ATOM 1334 C CA    . ALA A 1 184 ? 124.049 107.035 87.917  1.00 109.72 ? 184 ALA A CA    1 
ATOM 1335 C C     . ALA A 1 184 ? 125.524 107.070 88.289  1.00 110.27 ? 184 ALA A C     1 
ATOM 1336 O O     . ALA A 1 184 ? 126.001 108.006 88.937  1.00 111.20 ? 184 ALA A O     1 
ATOM 1337 C CB    . ALA A 1 184 ? 123.870 107.289 86.420  1.00 109.30 ? 184 ALA A CB    1 
ATOM 1338 N N     . SER A 1 185 ? 126.248 106.031 87.878  1.00 117.36 ? 185 SER A N     1 
ATOM 1339 C CA    . SER A 1 185 ? 127.681 105.986 88.129  1.00 116.77 ? 185 SER A CA    1 
ATOM 1340 C C     . SER A 1 185 ? 128.401 106.948 87.195  1.00 117.19 ? 185 SER A C     1 
ATOM 1341 O O     . SER A 1 185 ? 128.687 106.613 86.041  1.00 118.43 ? 185 SER A O     1 
ATOM 1342 C CB    . SER A 1 185 ? 128.217 104.563 87.966  1.00 116.48 ? 185 SER A CB    1 
ATOM 1343 O OG    . SER A 1 185 ? 127.830 103.742 89.056  1.00 117.27 ? 185 SER A OG    1 
ATOM 1344 N N     . GLU A 1 186 ? 128.698 108.149 87.693  1.00 111.54 ? 186 GLU A N     1 
ATOM 1345 C CA    . GLU A 1 186 ? 129.341 109.195 86.899  1.00 111.93 ? 186 GLU A CA    1 
ATOM 1346 C C     . GLU A 1 186 ? 130.850 108.949 86.874  1.00 112.57 ? 186 GLU A C     1 
ATOM 1347 O O     . GLU A 1 186 ? 131.642 109.617 87.541  1.00 114.49 ? 186 GLU A O     1 
ATOM 1348 C CB    . GLU A 1 186 ? 129.010 110.570 87.462  1.00 111.12 ? 186 GLU A CB    1 
ATOM 1349 C CG    . GLU A 1 186 ? 127.527 110.824 87.681  1.00 110.85 ? 186 GLU A CG    1 
ATOM 1350 C CD    . GLU A 1 186 ? 127.257 112.183 88.299  1.00 110.25 ? 186 GLU A CD    1 
ATOM 1351 O OE1   . GLU A 1 186 ? 127.915 113.165 87.897  1.00 110.90 ? 186 GLU A OE1   1 
ATOM 1352 O OE2   . GLU A 1 186 ? 126.389 112.268 89.192  1.00 110.84 ? 186 GLU A OE2   1 
ATOM 1353 N N     . GLY A 1 187 ? 131.242 107.954 86.079  1.00 118.83 ? 187 GLY A N     1 
ATOM 1354 C CA    . GLY A 1 187 ? 132.629 107.557 85.978  1.00 119.13 ? 187 GLY A CA    1 
ATOM 1355 C C     . GLY A 1 187 ? 133.125 106.657 87.087  1.00 120.86 ? 187 GLY A C     1 
ATOM 1356 O O     . GLY A 1 187 ? 134.318 106.325 87.104  1.00 121.78 ? 187 GLY A O     1 
ATOM 1357 N N     . CYS A 1 188 ? 132.262 106.257 88.015  1.00 125.21 ? 188 CYS A N     1 
ATOM 1358 C CA    . CYS A 1 188 ? 132.640 105.417 89.138  1.00 125.17 ? 188 CYS A CA    1 
ATOM 1359 C C     . CYS A 1 188 ? 132.066 104.012 88.961  1.00 126.85 ? 188 CYS A C     1 
ATOM 1360 O O     . CYS A 1 188 ? 131.466 103.682 87.932  1.00 126.78 ? 188 CYS A O     1 
ATOM 1361 C CB    . CYS A 1 188 ? 132.175 106.057 90.448  1.00 124.95 ? 188 CYS A CB    1 
ATOM 1362 S SG    . CYS A 1 188 ? 130.387 105.995 90.717  1.00 129.77 ? 188 CYS A SG    1 
ATOM 1363 N N     . SER A 1 189 ? 132.255 103.172 89.976  1.00 139.34 ? 189 SER A N     1 
ATOM 1364 C CA    . SER A 1 189 ? 131.714 101.820 89.996  1.00 138.79 ? 189 SER A CA    1 
ATOM 1365 C C     . SER A 1 189 ? 131.592 101.374 91.445  1.00 139.41 ? 189 SER A C     1 
ATOM 1366 O O     . SER A 1 189 ? 132.340 101.836 92.311  1.00 139.54 ? 189 SER A O     1 
ATOM 1367 C CB    . SER A 1 189 ? 132.602 100.845 89.216  1.00 138.21 ? 189 SER A CB    1 
ATOM 1368 O OG    . SER A 1 189 ? 133.972 101.172 89.378  1.00 140.01 ? 189 SER A OG    1 
ATOM 1369 N N     . ASN A 1 190 ? 130.646 100.468 91.701  1.00 148.90 ? 190 ASN A N     1 
ATOM 1370 C CA    . ASN A 1 190 ? 130.482 99.882  93.032  1.00 150.22 ? 190 ASN A CA    1 
ATOM 1371 C C     . ASN A 1 190 ? 129.940 98.454  92.901  1.00 150.86 ? 190 ASN A C     1 
ATOM 1372 O O     . ASN A 1 190 ? 128.929 98.215  92.220  1.00 150.68 ? 190 ASN A O     1 
ATOM 1373 C CB    . ASN A 1 190 ? 129.647 100.793 93.944  1.00 150.28 ? 190 ASN A CB    1 
ATOM 1374 C CG    . ASN A 1 190 ? 128.111 100.618 93.851  1.00 149.39 ? 190 ASN A CG    1 
ATOM 1375 O OD1   . ASN A 1 190 ? 127.530 99.621  94.290  1.00 149.06 ? 190 ASN A OD1   1 
ATOM 1376 N ND2   . ASN A 1 190 ? 127.457 101.621 93.277  1.00 149.03 ? 190 ASN A ND2   1 
ATOM 1377 N N     . PRO A 1 191 ? 130.693 97.466  93.384  1.00 153.75 ? 191 PRO A N     1 
ATOM 1378 C CA    . PRO A 1 191 ? 130.121 96.144  93.662  1.00 151.52 ? 191 PRO A CA    1 
ATOM 1379 C C     . PRO A 1 191 ? 129.750 95.977  95.129  1.00 152.22 ? 191 PRO A C     1 
ATOM 1380 O O     . PRO A 1 191 ? 130.401 96.510  96.030  1.00 152.38 ? 191 PRO A O     1 
ATOM 1381 C CB    . PRO A 1 191 ? 131.255 95.189  93.265  1.00 151.20 ? 191 PRO A CB    1 
ATOM 1382 C CG    . PRO A 1 191 ? 132.512 95.982  93.463  1.00 152.68 ? 191 PRO A CG    1 
ATOM 1383 C CD    . PRO A 1 191 ? 132.167 97.453  93.405  1.00 153.76 ? 191 PRO A CD    1 
ATOM 1384 N N     . LEU A 1 192 ? 128.684 95.233  95.370  1.00 152.55 ? 192 LEU A N     1 
ATOM 1385 C CA    . LEU A 1 192 ? 128.362 94.859  96.745  1.00 153.19 ? 192 LEU A CA    1 
ATOM 1386 C C     . LEU A 1 192 ? 128.118 93.368  96.913  1.00 151.63 ? 192 LEU A C     1 
ATOM 1387 O O     . LEU A 1 192 ? 128.392 92.824  97.986  1.00 152.03 ? 192 LEU A O     1 
ATOM 1388 C CB    . LEU A 1 192 ? 127.137 95.646  97.245  1.00 152.71 ? 192 LEU A CB    1 
ATOM 1389 C CG    . LEU A 1 192 ? 127.385 97.027  97.861  1.00 152.70 ? 192 LEU A CG    1 
ATOM 1390 C CD1   . LEU A 1 192 ? 126.142 97.509  98.587  1.00 152.34 ? 192 LEU A CD1   1 
ATOM 1391 C CD2   . LEU A 1 192 ? 128.578 97.017  98.809  1.00 150.82 ? 192 LEU A CD2   1 
ATOM 1392 N N     . GLY A 1 193 ? 127.618 92.694  95.886  1.00 149.95 ? 193 GLY A N     1 
ATOM 1393 C CA    . GLY A 1 193 ? 127.349 91.275  95.955  1.00 150.14 ? 193 GLY A CA    1 
ATOM 1394 C C     . GLY A 1 193 ? 125.867 90.976  96.125  1.00 151.51 ? 193 GLY A C     1 
ATOM 1395 O O     . GLY A 1 193 ? 125.109 91.734  96.735  1.00 151.35 ? 193 GLY A O     1 
ATOM 1396 N N     . GLY A 1 194 ? 125.453 89.840  95.569  1.00 154.13 ? 194 GLY A N     1 
ATOM 1397 C CA    . GLY A 1 194 ? 124.069 89.419  95.655  1.00 153.46 ? 194 GLY A CA    1 
ATOM 1398 C C     . GLY A 1 194 ? 123.106 90.177  94.772  1.00 153.70 ? 194 GLY A C     1 
ATOM 1399 O O     . GLY A 1 194 ? 121.897 90.134  95.017  1.00 153.82 ? 194 GLY A O     1 
ATOM 1400 N N     . GLY A 1 195 ? 123.601 90.867  93.746  1.00 151.14 ? 195 GLY A N     1 
ATOM 1401 C CA    . GLY A 1 195 ? 122.742 91.629  92.863  1.00 151.20 ? 195 GLY A CA    1 
ATOM 1402 C C     . GLY A 1 195 ? 122.358 93.003  93.361  1.00 150.78 ? 195 GLY A C     1 
ATOM 1403 O O     . GLY A 1 195 ? 121.333 93.536  92.923  1.00 149.53 ? 195 GLY A O     1 
ATOM 1404 N N     . ARG A 1 196 ? 123.143 93.595  94.256  1.00 147.91 ? 196 ARG A N     1 
ATOM 1405 C CA    . ARG A 1 196 ? 122.816 94.874  94.870  1.00 148.56 ? 196 ARG A CA    1 
ATOM 1406 C C     . ARG A 1 196 ? 123.905 95.897  94.580  1.00 147.92 ? 196 ARG A C     1 
ATOM 1407 O O     . ARG A 1 196 ? 125.098 95.582  94.627  1.00 147.22 ? 196 ARG A O     1 
ATOM 1408 C CB    . ARG A 1 196 ? 122.635 94.728  96.383  1.00 147.54 ? 196 ARG A CB    1 
ATOM 1409 C CG    . ARG A 1 196 ? 121.307 94.128  96.790  1.00 147.00 ? 196 ARG A CG    1 
ATOM 1410 C CD    . ARG A 1 196 ? 120.571 95.022  97.770  1.00 147.44 ? 196 ARG A CD    1 
ATOM 1411 N NE    . ARG A 1 196 ? 119.377 94.373  98.298  1.00 147.84 ? 196 ARG A NE    1 
ATOM 1412 C CZ    . ARG A 1 196 ? 118.871 94.600  99.502  1.00 146.61 ? 196 ARG A CZ    1 
ATOM 1413 N NH1   . ARG A 1 196 ? 119.442 95.445  100.345 1.00 145.83 ? 196 ARG A NH1   1 
ATOM 1414 N NH2   . ARG A 1 196 ? 117.767 93.960  99.871  1.00 146.29 ? 196 ARG A NH2   1 
ATOM 1415 N N     . GLU A 1 197 ? 123.481 97.120  94.271  1.00 136.24 ? 197 GLU A N     1 
ATOM 1416 C CA    . GLU A 1 197 ? 124.387 98.246  94.113  1.00 133.78 ? 197 GLU A CA    1 
ATOM 1417 C C     . GLU A 1 197 ? 123.732 99.479  94.721  1.00 132.95 ? 197 GLU A C     1 
ATOM 1418 O O     . GLU A 1 197 ? 122.506 99.567  94.826  1.00 133.80 ? 197 GLU A O     1 
ATOM 1419 C CB    . GLU A 1 197 ? 124.762 98.466  92.634  1.00 134.47 ? 197 GLU A CB    1 
ATOM 1420 C CG    . GLU A 1 197 ? 123.952 99.522  91.890  1.00 134.22 ? 197 GLU A CG    1 
ATOM 1421 C CD    . GLU A 1 197 ? 124.525 99.842  90.521  1.00 134.34 ? 197 GLU A CD    1 
ATOM 1422 O OE1   . GLU A 1 197 ? 125.754 99.715  90.342  1.00 133.51 ? 197 GLU A OE1   1 
ATOM 1423 O OE2   . GLU A 1 197 ? 123.744 100.222 89.623  1.00 133.90 ? 197 GLU A OE2   1 
ATOM 1424 N N     . VAL A 1 198 ? 124.567 100.424 95.145  1.00 128.95 ? 198 VAL A N     1 
ATOM 1425 C CA    . VAL A 1 198 ? 124.106 101.652 95.784  1.00 128.50 ? 198 VAL A CA    1 
ATOM 1426 C C     . VAL A 1 198 ? 124.057 102.759 94.735  1.00 128.22 ? 198 VAL A C     1 
ATOM 1427 O O     . VAL A 1 198 ? 125.001 102.937 93.953  1.00 130.02 ? 198 VAL A O     1 
ATOM 1428 C CB    . VAL A 1 198 ? 124.990 102.016 96.998  1.00 128.81 ? 198 VAL A CB    1 
ATOM 1429 C CG1   . VAL A 1 198 ? 126.480 101.976 96.671  1.00 129.22 ? 198 VAL A CG1   1 
ATOM 1430 C CG2   . VAL A 1 198 ? 124.616 103.376 97.581  1.00 127.20 ? 198 VAL A CG2   1 
ATOM 1431 N N     . TRP A 1 199 ? 122.926 103.460 94.671  1.00 113.68 ? 199 TRP A N     1 
ATOM 1432 C CA    . TRP A 1 199 ? 122.708 104.523 93.699  1.00 115.31 ? 199 TRP A CA    1 
ATOM 1433 C C     . TRP A 1 199 ? 122.527 105.816 94.483  1.00 110.80 ? 199 TRP A C     1 
ATOM 1434 O O     . TRP A 1 199 ? 121.423 106.112 94.950  1.00 109.99 ? 199 TRP A O     1 
ATOM 1435 C CB    . TRP A 1 199 ? 121.491 104.202 92.825  1.00 115.55 ? 199 TRP A CB    1 
ATOM 1436 C CG    . TRP A 1 199 ? 121.864 103.668 91.461  1.00 115.11 ? 199 TRP A CG    1 
ATOM 1437 C CD1   . TRP A 1 199 ? 122.922 102.861 91.172  1.00 115.12 ? 199 TRP A CD1   1 
ATOM 1438 C CD2   . TRP A 1 199 ? 121.145 103.837 90.230  1.00 113.60 ? 199 TRP A CD2   1 
ATOM 1439 N NE1   . TRP A 1 199 ? 122.935 102.554 89.835  1.00 114.20 ? 199 TRP A NE1   1 
ATOM 1440 C CE2   . TRP A 1 199 ? 121.855 103.142 89.234  1.00 114.23 ? 199 TRP A CE2   1 
ATOM 1441 C CE3   . TRP A 1 199 ? 119.995 104.537 89.867  1.00 111.36 ? 199 TRP A CE3   1 
ATOM 1442 C CZ2   . TRP A 1 199 ? 121.442 103.116 87.903  1.00 114.94 ? 199 TRP A CZ2   1 
ATOM 1443 C CZ3   . TRP A 1 199 ? 119.585 104.512 88.546  1.00 111.73 ? 199 TRP A CZ3   1 
ATOM 1444 C CH2   . TRP A 1 199 ? 120.307 103.806 87.580  1.00 114.18 ? 199 TRP A CH2   1 
ATOM 1445 N N     . PHE A 1 200 ? 123.608 106.580 94.628  1.00 100.21 ? 200 PHE A N     1 
ATOM 1446 C CA    . PHE A 1 200 ? 123.742 107.589 95.684  1.00 100.47 ? 200 PHE A CA    1 
ATOM 1447 C C     . PHE A 1 200 ? 123.168 108.930 95.219  1.00 99.40  ? 200 PHE A C     1 
ATOM 1448 O O     . PHE A 1 200 ? 123.857 109.948 95.189  1.00 102.27 ? 200 PHE A O     1 
ATOM 1449 C CB    . PHE A 1 200 ? 125.230 107.721 96.199  1.00 102.04 ? 200 PHE A CB    1 
ATOM 1450 C CG    . PHE A 1 200 ? 126.282 108.024 95.130  1.00 100.97 ? 200 PHE A CG    1 
ATOM 1451 C CD1   . PHE A 1 200 ? 126.717 107.051 94.233  1.00 101.30 ? 200 PHE A CD1   1 
ATOM 1452 C CD2   . PHE A 1 200 ? 126.902 109.272 95.095  1.00 100.09 ? 200 PHE A CD2   1 
ATOM 1453 C CE1   . PHE A 1 200 ? 127.684 107.337 93.282  1.00 101.36 ? 200 PHE A CE1   1 
ATOM 1454 C CE2   . PHE A 1 200 ? 127.870 109.563 94.148  1.00 100.82 ? 200 PHE A CE2   1 
ATOM 1455 C CZ    . PHE A 1 200 ? 128.263 108.593 93.244  1.00 100.13 ? 200 PHE A CZ    1 
ATOM 1456 N N     . GLY A 1 201 ? 121.875 108.945 94.918  1.00 71.87  ? 201 GLY A N     1 
ATOM 1457 C CA    . GLY A 1 201 ? 121.250 110.170 94.461  1.00 69.83  ? 201 GLY A CA    1 
ATOM 1458 C C     . GLY A 1 201 ? 120.868 111.116 95.579  1.00 62.15  ? 201 GLY A C     1 
ATOM 1459 O O     . GLY A 1 201 ? 121.574 111.201 96.587  1.00 64.86  ? 201 GLY A O     1 
ATOM 1460 N N     . PHE A 1 202 ? 119.753 111.829 95.434  1.00 52.15  ? 202 PHE A N     1 
ATOM 1461 C CA    . PHE A 1 202 ? 119.451 112.842 96.434  1.00 55.20  ? 202 PHE A CA    1 
ATOM 1462 C C     . PHE A 1 202 ? 117.957 113.091 96.519  1.00 60.72  ? 202 PHE A C     1 
ATOM 1463 O O     . PHE A 1 202 ? 117.247 112.994 95.519  1.00 65.10  ? 202 PHE A O     1 
ATOM 1464 C CB    . PHE A 1 202 ? 120.178 114.164 96.150  1.00 53.02  ? 202 PHE A CB    1 
ATOM 1465 C CG    . PHE A 1 202 ? 119.958 114.733 94.771  1.00 56.53  ? 202 PHE A CG    1 
ATOM 1466 C CD1   . PHE A 1 202 ? 120.745 114.332 93.699  1.00 63.80  ? 202 PHE A CD1   1 
ATOM 1467 C CD2   . PHE A 1 202 ? 119.010 115.722 94.563  1.00 52.65  ? 202 PHE A CD2   1 
ATOM 1468 C CE1   . PHE A 1 202 ? 120.558 114.872 92.440  1.00 62.30  ? 202 PHE A CE1   1 
ATOM 1469 C CE2   . PHE A 1 202 ? 118.823 116.270 93.304  1.00 56.39  ? 202 PHE A CE2   1 
ATOM 1470 C CZ    . PHE A 1 202 ? 119.602 115.847 92.244  1.00 60.38  ? 202 PHE A CZ    1 
ATOM 1471 N N     . HIS A 1 203 ? 117.500 113.423 97.723  1.00 53.05  ? 203 HIS A N     1 
ATOM 1472 C CA    . HIS A 1 203 ? 116.122 113.839 97.969  1.00 48.39  ? 203 HIS A CA    1 
ATOM 1473 C C     . HIS A 1 203 ? 115.989 115.313 97.617  1.00 43.47  ? 203 HIS A C     1 
ATOM 1474 O O     . HIS A 1 203 ? 116.441 116.184 98.361  1.00 46.89  ? 203 HIS A O     1 
ATOM 1475 C CB    . HIS A 1 203 ? 115.752 113.593 99.426  1.00 49.25  ? 203 HIS A CB    1 
ATOM 1476 C CG    . HIS A 1 203 ? 114.825 112.438 99.631  1.00 47.46  ? 203 HIS A CG    1 
ATOM 1477 N ND1   . HIS A 1 203 ? 113.501 112.468 99.251  1.00 52.92  ? 203 HIS A ND1   1 
ATOM 1478 C CD2   . HIS A 1 203 ? 115.031 111.218 100.181 1.00 48.37  ? 203 HIS A CD2   1 
ATOM 1479 C CE1   . HIS A 1 203 ? 112.931 111.316 99.557  1.00 50.40  ? 203 HIS A CE1   1 
ATOM 1480 N NE2   . HIS A 1 203 ? 113.838 110.540 100.122 1.00 54.22  ? 203 HIS A NE2   1 
ATOM 1481 N N     . GLN A 1 204 ? 115.356 115.604 96.491  1.00 38.65  ? 204 GLN A N     1 
ATOM 1482 C CA    . GLN A 1 204 ? 115.181 116.972 96.030  1.00 42.05  ? 204 GLN A CA    1 
ATOM 1483 C C     . GLN A 1 204 ? 113.834 117.502 96.495  1.00 36.43  ? 204 GLN A C     1 
ATOM 1484 O O     . GLN A 1 204 ? 112.804 116.849 96.303  1.00 48.13  ? 204 GLN A O     1 
ATOM 1485 C CB    . GLN A 1 204 ? 115.278 117.047 94.509  1.00 46.66  ? 204 GLN A CB    1 
ATOM 1486 C CG    . GLN A 1 204 ? 115.942 118.299 93.998  1.00 45.41  ? 204 GLN A CG    1 
ATOM 1487 C CD    . GLN A 1 204 ? 115.869 118.407 92.499  1.00 46.80  ? 204 GLN A CD    1 
ATOM 1488 O OE1   . GLN A 1 204 ? 116.890 118.433 91.818  1.00 44.95  ? 204 GLN A OE1   1 
ATOM 1489 N NE2   . GLN A 1 204 ? 114.658 118.471 91.972  1.00 48.90  ? 204 GLN A NE2   1 
ATOM 1490 N N     . SER A 1 205 ? 113.844 118.683 97.105  1.00 25.29  ? 205 SER A N     1 
ATOM 1491 C CA    . SER A 1 205 ? 112.630 119.288 97.626  1.00 27.58  ? 205 SER A CA    1 
ATOM 1492 C C     . SER A 1 205 ? 112.784 120.798 97.569  1.00 33.56  ? 205 SER A C     1 
ATOM 1493 O O     . SER A 1 205 ? 113.886 121.317 97.393  1.00 43.89  ? 205 SER A O     1 
ATOM 1494 C CB    . SER A 1 205 ? 112.343 118.836 99.065  1.00 38.06  ? 205 SER A CB    1 
ATOM 1495 O OG    . SER A 1 205 ? 112.321 117.424 99.196  1.00 42.39  ? 205 SER A OG    1 
ATOM 1496 N N     . VAL A 1 206 ? 111.666 121.503 97.704  1.00 26.05  ? 206 VAL A N     1 
ATOM 1497 C CA    . VAL A 1 206 ? 111.673 122.956 97.814  1.00 33.96  ? 206 VAL A CA    1 
ATOM 1498 C C     . VAL A 1 206 ? 110.679 123.368 98.898  1.00 36.74  ? 206 VAL A C     1 
ATOM 1499 O O     . VAL A 1 206 ? 109.593 122.789 99.020  1.00 42.27  ? 206 VAL A O     1 
ATOM 1500 C CB    . VAL A 1 206 ? 111.403 123.635 96.443  1.00 35.88  ? 206 VAL A CB    1 
ATOM 1501 C CG1   . VAL A 1 206 ? 110.025 123.315 95.877  1.00 33.49  ? 206 VAL A CG1   1 
ATOM 1502 C CG2   . VAL A 1 206 ? 111.627 125.140 96.520  1.00 39.34  ? 206 VAL A CG2   1 
ATOM 1503 N N     . ARG A 1 207 ? 111.097 124.306 99.750  1.00 43.68  ? 207 ARG A N     1 
ATOM 1504 C CA    . ARG A 1 207 ? 110.383 124.729 100.946 1.00 42.68  ? 207 ARG A CA    1 
ATOM 1505 C C     . ARG A 1 207 ? 110.215 126.244 100.937 1.00 42.98  ? 207 ARG A C     1 
ATOM 1506 O O     . ARG A 1 207 ? 111.084 126.954 100.426 1.00 49.28  ? 207 ARG A O     1 
ATOM 1507 C CB    . ARG A 1 207 ? 111.136 124.295 102.219 1.00 41.55  ? 207 ARG A CB    1 
ATOM 1508 C CG    . ARG A 1 207 ? 111.916 122.977 102.150 1.00 42.53  ? 207 ARG A CG    1 
ATOM 1509 C CD    . ARG A 1 207 ? 111.014 121.764 101.978 1.00 38.11  ? 207 ARG A CD    1 
ATOM 1510 N NE    . ARG A 1 207 ? 109.995 121.669 103.016 1.00 37.72  ? 207 ARG A NE    1 
ATOM 1511 C CZ    . ARG A 1 207 ? 108.814 121.091 102.850 1.00 41.34  ? 207 ARG A CZ    1 
ATOM 1512 N NH1   . ARG A 1 207 ? 108.470 120.539 101.698 1.00 38.11  ? 207 ARG A NH1   1 
ATOM 1513 N NH2   . ARG A 1 207 ? 107.954 121.070 103.863 1.00 46.88  ? 207 ARG A NH2   1 
ATOM 1514 N N     . PRO A 1 208 ? 109.116 126.771 101.482 1.00 46.59  ? 208 PRO A N     1 
ATOM 1515 C CA    . PRO A 1 208 ? 108.891 128.220 101.431 1.00 58.84  ? 208 PRO A CA    1 
ATOM 1516 C C     . PRO A 1 208 ? 109.713 128.958 102.483 1.00 55.21  ? 208 PRO A C     1 
ATOM 1517 O O     . PRO A 1 208 ? 110.260 128.367 103.412 1.00 52.56  ? 208 PRO A O     1 
ATOM 1518 C CB    . PRO A 1 208 ? 107.390 128.350 101.704 1.00 56.75  ? 208 PRO A CB    1 
ATOM 1519 C CG    . PRO A 1 208 ? 107.069 127.190 102.555 1.00 47.20  ? 208 PRO A CG    1 
ATOM 1520 C CD    . PRO A 1 208 ? 108.004 126.080 102.168 1.00 44.53  ? 208 PRO A CD    1 
ATOM 1521 N N     . SER A 1 209 ? 109.821 130.272 102.299 1.00 48.14  ? 209 SER A N     1 
ATOM 1522 C CA    . SER A 1 209 ? 110.636 131.127 103.166 1.00 52.02  ? 209 SER A CA    1 
ATOM 1523 C C     . SER A 1 209 ? 110.084 132.549 103.114 1.00 52.08  ? 209 SER A C     1 
ATOM 1524 O O     . SER A 1 209 ? 108.922 132.769 102.753 1.00 49.53  ? 209 SER A O     1 
ATOM 1525 C CB    . SER A 1 209 ? 112.109 131.137 102.762 1.00 51.31  ? 209 SER A CB    1 
ATOM 1526 O OG    . SER A 1 209 ? 112.586 129.902 102.264 1.00 46.70  ? 209 SER A OG    1 
ATOM 1527 N N     . LEU A 1 210 ? 110.913 133.511 103.536 1.00 50.34  ? 210 LEU A N     1 
ATOM 1528 C CA    . LEU A 1 210 ? 110.619 134.934 103.373 1.00 49.82  ? 210 LEU A CA    1 
ATOM 1529 C C     . LEU A 1 210 ? 111.011 135.439 101.987 1.00 48.30  ? 210 LEU A C     1 
ATOM 1530 O O     . LEU A 1 210 ? 110.157 135.861 101.200 1.00 49.38  ? 210 LEU A O     1 
ATOM 1531 C CB    . LEU A 1 210 ? 111.361 135.747 104.441 1.00 53.18  ? 210 LEU A CB    1 
ATOM 1532 C CG    . LEU A 1 210 ? 110.921 135.856 105.902 1.00 56.39  ? 210 LEU A CG    1 
ATOM 1533 C CD1   . LEU A 1 210 ? 111.998 136.602 106.669 1.00 56.97  ? 210 LEU A CD1   1 
ATOM 1534 C CD2   . LEU A 1 210 ? 109.609 136.610 106.019 1.00 50.78  ? 210 LEU A CD2   1 
ATOM 1535 N N     . TRP A 1 211 ? 112.308 135.392 101.670 1.00 52.74  ? 211 TRP A N     1 
ATOM 1536 C CA    . TRP A 1 211 ? 112.833 136.114 100.513 1.00 59.23  ? 211 TRP A CA    1 
ATOM 1537 C C     . TRP A 1 211 ? 112.659 135.318 99.224  1.00 56.99  ? 211 TRP A C     1 
ATOM 1538 O O     . TRP A 1 211 ? 112.065 135.801 98.254  1.00 57.60  ? 211 TRP A O     1 
ATOM 1539 C CB    . TRP A 1 211 ? 114.308 136.451 100.747 1.00 57.74  ? 211 TRP A CB    1 
ATOM 1540 C CG    . TRP A 1 211 ? 114.842 137.530 99.853  1.00 56.97  ? 211 TRP A CG    1 
ATOM 1541 C CD1   . TRP A 1 211 ? 114.118 138.395 99.088  1.00 53.81  ? 211 TRP A CD1   1 
ATOM 1542 C CD2   . TRP A 1 211 ? 116.221 137.852 99.628  1.00 60.04  ? 211 TRP A CD2   1 
ATOM 1543 N NE1   . TRP A 1 211 ? 114.958 139.237 98.401  1.00 58.67  ? 211 TRP A NE1   1 
ATOM 1544 C CE2   . TRP A 1 211 ? 116.254 138.925 98.716  1.00 61.02  ? 211 TRP A CE2   1 
ATOM 1545 C CE3   . TRP A 1 211 ? 117.429 137.338 100.111 1.00 58.60  ? 211 TRP A CE3   1 
ATOM 1546 C CZ2   . TRP A 1 211 ? 117.449 139.493 98.275  1.00 57.65  ? 211 TRP A CZ2   1 
ATOM 1547 C CZ3   . TRP A 1 211 ? 118.615 137.904 99.672  1.00 61.26  ? 211 TRP A CZ3   1 
ATOM 1548 C CH2   . TRP A 1 211 ? 118.615 138.970 98.763  1.00 55.94  ? 211 TRP A CH2   1 
ATOM 1549 N N     . LYS A 1 212 ? 113.205 134.108 99.182  1.00 43.31  ? 212 LYS A N     1 
ATOM 1550 C CA    . LYS A 1 212 ? 113.133 133.248 98.013  1.00 38.64  ? 212 LYS A CA    1 
ATOM 1551 C C     . LYS A 1 212 ? 112.502 131.926 98.420  1.00 48.66  ? 212 LYS A C     1 
ATOM 1552 O O     . LYS A 1 212 ? 112.466 131.582 99.597  1.00 55.01  ? 212 LYS A O     1 
ATOM 1553 C CB    . LYS A 1 212 ? 114.520 132.996 97.405  1.00 45.27  ? 212 LYS A CB    1 
ATOM 1554 C CG    . LYS A 1 212 ? 115.482 134.176 97.461  1.00 48.36  ? 212 LYS A CG    1 
ATOM 1555 C CD    . LYS A 1 212 ? 115.117 135.237 96.434  1.00 47.93  ? 212 LYS A CD    1 
ATOM 1556 C CE    . LYS A 1 212 ? 116.355 135.957 95.923  1.00 44.77  ? 212 LYS A CE    1 
ATOM 1557 N NZ    . LYS A 1 212 ? 117.242 135.060 95.132  1.00 45.73  ? 212 LYS A NZ    1 
ATOM 1558 N N     . MET A 1 213 ? 111.981 131.183 97.445  1.00 52.76  ? 213 MET A N     1 
ATOM 1559 C CA    . MET A 1 213 ? 111.572 129.804 97.717  1.00 47.73  ? 213 MET A CA    1 
ATOM 1560 C C     . MET A 1 213 ? 112.779 128.914 97.472  1.00 39.53  ? 213 MET A C     1 
ATOM 1561 O O     . MET A 1 213 ? 112.920 128.254 96.442  1.00 47.47  ? 213 MET A O     1 
ATOM 1562 C CB    . MET A 1 213 ? 110.373 129.392 96.884  1.00 43.94  ? 213 MET A CB    1 
ATOM 1563 C CG    . MET A 1 213 ? 109.247 130.363 97.005  1.00 45.51  ? 213 MET A CG    1 
ATOM 1564 S SD    . MET A 1 213 ? 107.687 129.716 96.448  1.00 42.35  ? 213 MET A SD    1 
ATOM 1565 C CE    . MET A 1 213 ? 107.770 128.059 97.086  1.00 45.37  ? 213 MET A CE    1 
ATOM 1566 N N     . MET A 1 214 ? 113.655 128.907 98.466  1.00 28.71  ? 214 MET A N     1 
ATOM 1567 C CA    . MET A 1 214 ? 114.997 128.376 98.323  1.00 30.33  ? 214 MET A CA    1 
ATOM 1568 C C     . MET A 1 214 ? 114.964 126.853 98.276  1.00 27.31  ? 214 MET A C     1 
ATOM 1569 O O     . MET A 1 214 ? 114.132 126.211 98.918  1.00 23.12  ? 214 MET A O     1 
ATOM 1570 C CB    . MET A 1 214 ? 115.836 128.881 99.491  1.00 33.46  ? 214 MET A CB    1 
ATOM 1571 C CG    . MET A 1 214 ? 115.509 130.324 99.861  1.00 36.16  ? 214 MET A CG    1 
ATOM 1572 S SD    . MET A 1 214 ? 115.874 130.764 101.563 1.00 13.55  ? 214 MET A SD    1 
ATOM 1573 C CE    . MET A 1 214 ? 117.608 130.382 101.623 1.00 29.31  ? 214 MET A CE    1 
ATOM 1574 N N     . LEU A 1 215 ? 115.858 126.277 97.474  1.00 42.66  ? 215 LEU A N     1 
ATOM 1575 C CA    . LEU A 1 215 ? 115.838 124.838 97.243  1.00 47.26  ? 215 LEU A CA    1 
ATOM 1576 C C     . LEU A 1 215 ? 116.341 124.075 98.461  1.00 46.34  ? 215 LEU A C     1 
ATOM 1577 O O     . LEU A 1 215 ? 117.062 124.600 99.299  1.00 51.31  ? 215 LEU A O     1 
ATOM 1578 C CB    . LEU A 1 215 ? 116.675 124.455 96.024  1.00 50.06  ? 215 LEU A CB    1 
ATOM 1579 C CG    . LEU A 1 215 ? 115.944 124.301 94.692  1.00 44.44  ? 215 LEU A CG    1 
ATOM 1580 C CD1   . LEU A 1 215 ? 115.256 122.948 94.758  1.00 42.86  ? 215 LEU A CD1   1 
ATOM 1581 C CD2   . LEU A 1 215 ? 114.950 125.406 94.363  1.00 40.75  ? 215 LEU A CD2   1 
ATOM 1582 N N     . ASN A 1 216 ? 115.958 122.805 98.536  1.00 30.50  ? 216 ASN A N     1 
ATOM 1583 C CA    . ASN A 1 216 ? 116.281 121.964 99.682  1.00 30.85  ? 216 ASN A CA    1 
ATOM 1584 C C     . ASN A 1 216 ? 116.848 120.669 99.133  1.00 29.42  ? 216 ASN A C     1 
ATOM 1585 O O     . ASN A 1 216 ? 116.098 119.832 98.629  1.00 41.75  ? 216 ASN A O     1 
ATOM 1586 C CB    . ASN A 1 216 ? 115.041 121.704 100.533 1.00 35.74  ? 216 ASN A CB    1 
ATOM 1587 C CG    . ASN A 1 216 ? 115.366 121.128 101.899 1.00 37.42  ? 216 ASN A CG    1 
ATOM 1588 O OD1   . ASN A 1 216 ? 116.526 121.096 102.300 1.00 37.02  ? 216 ASN A OD1   1 
ATOM 1589 N ND2   . ASN A 1 216 ? 114.352 120.656 102.609 1.00 36.74  ? 216 ASN A ND2   1 
ATOM 1590 N N     . ILE A 1 217 ? 118.158 120.501 99.228  1.00 24.06  ? 217 ILE A N     1 
ATOM 1591 C CA    . ILE A 1 217 ? 118.830 119.321 98.711  1.00 30.41  ? 217 ILE A CA    1 
ATOM 1592 C C     . ILE A 1 217 ? 119.377 118.518 99.879  1.00 35.87  ? 217 ILE A C     1 
ATOM 1593 O O     . ILE A 1 217 ? 120.119 119.046 100.712 1.00 44.43  ? 217 ILE A O     1 
ATOM 1594 C CB    . ILE A 1 217 ? 119.962 119.696 97.736  1.00 34.06  ? 217 ILE A CB    1 
ATOM 1595 C CG1   . ILE A 1 217 ? 119.513 120.819 96.799  1.00 36.60  ? 217 ILE A CG1   1 
ATOM 1596 C CG2   . ILE A 1 217 ? 120.414 118.478 96.960  1.00 39.94  ? 217 ILE A CG2   1 
ATOM 1597 C CD1   . ILE A 1 217 ? 118.461 120.417 95.806  1.00 37.40  ? 217 ILE A CD1   1 
ATOM 1598 N N     . ASP A 1 218 ? 119.008 117.244 99.944  1.00 21.58  ? 218 ASP A N     1 
ATOM 1599 C CA    . ASP A 1 218 ? 119.601 116.324 100.900 1.00 31.81  ? 218 ASP A CA    1 
ATOM 1600 C C     . ASP A 1 218 ? 119.974 115.044 100.180 1.00 28.96  ? 218 ASP A C     1 
ATOM 1601 O O     . ASP A 1 218 ? 119.258 114.595 99.285  1.00 30.61  ? 218 ASP A O     1 
ATOM 1602 C CB    . ASP A 1 218 ? 118.663 116.006 102.066 1.00 40.60  ? 218 ASP A CB    1 
ATOM 1603 C CG    . ASP A 1 218 ? 119.083 116.684 103.353 1.00 40.87  ? 218 ASP A CG    1 
ATOM 1604 O OD1   . ASP A 1 218 ? 120.114 117.385 103.350 1.00 36.02  ? 218 ASP A OD1   1 
ATOM 1605 O OD2   . ASP A 1 218 ? 118.395 116.498 104.376 1.00 36.88  ? 218 ASP A OD2   1 
ATOM 1606 N N     . VAL A 1 219 ? 121.098 114.463 100.578 1.00 38.75  ? 219 VAL A N     1 
ATOM 1607 C CA    . VAL A 1 219 ? 121.574 113.212 100.001 1.00 46.02  ? 219 VAL A CA    1 
ATOM 1608 C C     . VAL A 1 219 ? 120.658 112.077 100.448 1.00 40.75  ? 219 VAL A C     1 
ATOM 1609 O O     . VAL A 1 219 ? 120.065 112.117 101.535 1.00 38.45  ? 219 VAL A O     1 
ATOM 1610 C CB    . VAL A 1 219 ? 123.059 112.963 100.358 1.00 42.72  ? 219 VAL A CB    1 
ATOM 1611 C CG1   . VAL A 1 219 ? 123.867 114.223 100.116 1.00 33.26  ? 219 VAL A CG1   1 
ATOM 1612 C CG2   . VAL A 1 219 ? 123.255 112.517 101.805 1.00 43.45  ? 219 VAL A CG2   1 
ATOM 1613 N N     . SER A 1 220 ? 120.462 111.103 99.562  1.00 63.74  ? 220 SER A N     1 
ATOM 1614 C CA    . SER A 1 220 ? 119.532 110.011 99.811  1.00 71.59  ? 220 SER A CA    1 
ATOM 1615 C C     . SER A 1 220 ? 120.247 108.673 99.922  1.00 76.49  ? 220 SER A C     1 
ATOM 1616 O O     . SER A 1 220 ? 120.120 108.002 100.952 1.00 83.96  ? 220 SER A O     1 
ATOM 1617 C CB    . SER A 1 220 ? 118.472 109.964 98.706  1.00 74.08  ? 220 SER A CB    1 
ATOM 1618 O OG    . SER A 1 220 ? 117.441 109.053 99.037  1.00 72.17  ? 220 SER A OG    1 
ATOM 1619 N N     . ALA A 1 221 ? 120.997 108.291 98.881  1.00 87.99  ? 221 ALA A N     1 
ATOM 1620 C CA    . ALA A 1 221 ? 121.937 107.163 98.867  1.00 92.01  ? 221 ALA A CA    1 
ATOM 1621 C C     . ALA A 1 221 ? 121.261 105.832 99.194  1.00 92.04  ? 221 ALA A C     1 
ATOM 1622 O O     . ALA A 1 221 ? 121.459 105.251 100.259 1.00 90.93  ? 221 ALA A O     1 
ATOM 1623 C CB    . ALA A 1 221 ? 123.129 107.427 99.790  1.00 90.05  ? 221 ALA A CB    1 
ATOM 1624 N N     . THR A 1 222 ? 120.405 105.391 98.281  1.00 105.68 ? 222 THR A N     1 
ATOM 1625 C CA    . THR A 1 222 ? 119.653 104.158 98.457  1.00 106.18 ? 222 THR A CA    1 
ATOM 1626 C C     . THR A 1 222 ? 120.291 103.028 97.650  1.00 106.93 ? 222 THR A C     1 
ATOM 1627 O O     . THR A 1 222 ? 121.348 103.189 97.034  1.00 105.62 ? 222 THR A O     1 
ATOM 1628 C CB    . THR A 1 222 ? 118.206 104.347 98.023  1.00 108.53 ? 222 THR A CB    1 
ATOM 1629 O OG1   . THR A 1 222 ? 118.112 104.069 96.624  1.00 105.88 ? 222 THR A OG1   1 
ATOM 1630 C CG2   . THR A 1 222 ? 117.764 105.779 98.271  1.00 106.64 ? 222 THR A CG2   1 
ATOM 1631 N N     . ALA A 1 223 ? 119.628 101.875 97.626  1.00 121.48 ? 223 ALA A N     1 
ATOM 1632 C CA    . ALA A 1 223 ? 120.080 100.717 96.870  1.00 123.45 ? 223 ALA A CA    1 
ATOM 1633 C C     . ALA A 1 223 ? 119.371 100.643 95.519  1.00 123.48 ? 223 ALA A C     1 
ATOM 1634 O O     . ALA A 1 223 ? 118.340 101.282 95.292  1.00 121.25 ? 223 ALA A O     1 
ATOM 1635 C CB    . ALA A 1 223 ? 119.841 99.430  97.662  1.00 120.59 ? 223 ALA A CB    1 
ATOM 1636 N N     . PHE A 1 224 ? 119.946 99.850  94.616  1.00 131.48 ? 224 PHE A N     1 
ATOM 1637 C CA    . PHE A 1 224 ? 119.395 99.701  93.276  1.00 129.95 ? 224 PHE A CA    1 
ATOM 1638 C C     . PHE A 1 224 ? 119.749 98.326  92.732  1.00 130.21 ? 224 PHE A C     1 
ATOM 1639 O O     . PHE A 1 224 ? 120.721 97.698  93.160  1.00 131.62 ? 224 PHE A O     1 
ATOM 1640 C CB    . PHE A 1 224 ? 119.906 100.791 92.333  1.00 128.76 ? 224 PHE A CB    1 
ATOM 1641 C CG    . PHE A 1 224 ? 118.956 101.119 91.227  1.00 129.76 ? 224 PHE A CG    1 
ATOM 1642 C CD1   . PHE A 1 224 ? 117.867 101.937 91.464  1.00 127.91 ? 224 PHE A CD1   1 
ATOM 1643 C CD2   . PHE A 1 224 ? 119.146 100.603 89.955  1.00 131.81 ? 224 PHE A CD2   1 
ATOM 1644 C CE1   . PHE A 1 224 ? 116.982 102.247 90.452  1.00 129.26 ? 224 PHE A CE1   1 
ATOM 1645 C CE2   . PHE A 1 224 ? 118.264 100.901 88.935  1.00 131.40 ? 224 PHE A CE2   1 
ATOM 1646 C CZ    . PHE A 1 224 ? 117.181 101.728 89.186  1.00 131.18 ? 224 PHE A CZ    1 
ATOM 1647 N N     . TYR A 1 225 ? 118.935 97.867  91.778  1.00 137.46 ? 225 TYR A N     1 
ATOM 1648 C CA    . TYR A 1 225 ? 119.089 96.568  91.136  1.00 137.55 ? 225 TYR A CA    1 
ATOM 1649 C C     . TYR A 1 225 ? 119.774 96.665  89.774  1.00 138.37 ? 225 TYR A C     1 
ATOM 1650 O O     . TYR A 1 225 ? 119.497 95.844  88.893  1.00 139.56 ? 225 TYR A O     1 
ATOM 1651 C CB    . TYR A 1 225 ? 117.721 95.892  91.002  1.00 139.49 ? 225 TYR A CB    1 
ATOM 1652 C CG    . TYR A 1 225 ? 117.742 94.378  91.000  1.00 140.79 ? 225 TYR A CG    1 
ATOM 1653 C CD1   . TYR A 1 225 ? 118.190 93.663  92.105  1.00 140.69 ? 225 TYR A CD1   1 
ATOM 1654 C CD2   . TYR A 1 225 ? 117.293 93.666  89.893  1.00 140.80 ? 225 TYR A CD2   1 
ATOM 1655 C CE1   . TYR A 1 225 ? 118.204 92.277  92.102  1.00 140.56 ? 225 TYR A CE1   1 
ATOM 1656 C CE2   . TYR A 1 225 ? 117.301 92.283  89.879  1.00 139.71 ? 225 TYR A CE2   1 
ATOM 1657 C CZ    . TYR A 1 225 ? 117.757 91.594  90.984  1.00 140.40 ? 225 TYR A CZ    1 
ATOM 1658 O OH    . TYR A 1 225 ? 117.764 90.218  90.967  1.00 140.75 ? 225 TYR A OH    1 
ATOM 1659 N N     . LYS A 1 226 ? 120.630 97.677  89.583  1.00 144.38 ? 226 LYS A N     1 
ATOM 1660 C CA    . LYS A 1 226 ? 121.485 97.890  88.411  1.00 145.17 ? 226 LYS A CA    1 
ATOM 1661 C C     . LYS A 1 226 ? 120.736 98.028  87.086  1.00 145.58 ? 226 LYS A C     1 
ATOM 1662 O O     . LYS A 1 226 ? 119.506 98.147  87.056  1.00 146.53 ? 226 LYS A O     1 
ATOM 1663 C CB    . LYS A 1 226 ? 122.533 96.776  88.294  1.00 145.21 ? 226 LYS A CB    1 
ATOM 1664 C CG    . LYS A 1 226 ? 123.406 96.613  89.523  1.00 144.48 ? 226 LYS A CG    1 
ATOM 1665 C CD    . LYS A 1 226 ? 123.669 95.155  89.841  1.00 144.49 ? 226 LYS A CD    1 
ATOM 1666 C CE    . LYS A 1 226 ? 124.625 95.024  91.015  1.00 143.67 ? 226 LYS A CE    1 
ATOM 1667 N NZ    . LYS A 1 226 ? 124.987 93.609  91.290  1.00 144.39 ? 226 LYS A NZ    1 
ATOM 1668 N N     . ALA A 1 227 ? 121.488 98.052  85.985  1.00 143.92 ? 227 ALA A N     1 
ATOM 1669 C CA    . ALA A 1 227 ? 120.941 98.201  84.639  1.00 144.38 ? 227 ALA A CA    1 
ATOM 1670 C C     . ALA A 1 227 ? 121.668 97.288  83.662  1.00 144.72 ? 227 ALA A C     1 
ATOM 1671 O O     . ALA A 1 227 ? 121.995 97.685  82.539  1.00 145.47 ? 227 ALA A O     1 
ATOM 1672 C CB    . ALA A 1 227 ? 121.023 99.651  84.170  1.00 142.58 ? 227 ALA A CB    1 
ATOM 1673 N N     . GLN A 1 228 ? 121.932 96.056  84.072  1.00 149.34 ? 228 GLN A N     1 
ATOM 1674 C CA    . GLN A 1 228 ? 122.743 95.126  83.305  1.00 150.00 ? 228 GLN A CA    1 
ATOM 1675 C C     . GLN A 1 228 ? 121.996 93.804  83.096  1.00 150.71 ? 228 GLN A C     1 
ATOM 1676 O O     . GLN A 1 228 ? 121.154 93.433  83.922  1.00 151.78 ? 228 GLN A O     1 
ATOM 1677 C CB    . GLN A 1 228 ? 124.100 94.947  84.022  1.00 149.90 ? 228 GLN A CB    1 
ATOM 1678 C CG    . GLN A 1 228 ? 124.082 94.509  85.482  1.00 150.19 ? 228 GLN A CG    1 
ATOM 1679 C CD    . GLN A 1 228 ? 124.072 93.013  85.661  1.00 150.59 ? 228 GLN A CD    1 
ATOM 1680 O OE1   . GLN A 1 228 ? 124.149 92.265  84.696  1.00 150.52 ? 228 GLN A OE1   1 
ATOM 1681 N NE2   . GLN A 1 228 ? 124.027 92.568  86.906  1.00 149.68 ? 228 GLN A NE2   1 
ATOM 1682 N N     . PRO A 1 229 ? 122.243 93.093  81.979  1.00 148.86 ? 229 PRO A N     1 
ATOM 1683 C CA    . PRO A 1 229 ? 121.352 91.990  81.564  1.00 148.72 ? 229 PRO A CA    1 
ATOM 1684 C C     . PRO A 1 229 ? 121.360 90.780  82.493  1.00 150.56 ? 229 PRO A C     1 
ATOM 1685 O O     . PRO A 1 229 ? 122.161 90.651  83.418  1.00 150.51 ? 229 PRO A O     1 
ATOM 1686 C CB    . PRO A 1 229 ? 121.877 91.597  80.180  1.00 148.87 ? 229 PRO A CB    1 
ATOM 1687 C CG    . PRO A 1 229 ? 122.646 92.737  79.696  1.00 148.46 ? 229 PRO A CG    1 
ATOM 1688 C CD    . PRO A 1 229 ? 123.104 93.540  80.863  1.00 149.68 ? 229 PRO A CD    1 
ATOM 1689 N N     . VAL A 1 230 ? 120.428 89.865  82.211  1.00 155.03 ? 230 VAL A N     1 
ATOM 1690 C CA    . VAL A 1 230 ? 120.093 88.810  83.162  1.00 154.16 ? 230 VAL A CA    1 
ATOM 1691 C C     . VAL A 1 230 ? 121.077 87.645  83.146  1.00 155.09 ? 230 VAL A C     1 
ATOM 1692 O O     . VAL A 1 230 ? 120.978 86.760  84.009  1.00 154.16 ? 230 VAL A O     1 
ATOM 1693 C CB    . VAL A 1 230 ? 118.666 88.294  82.910  1.00 153.25 ? 230 VAL A CB    1 
ATOM 1694 C CG1   . VAL A 1 230 ? 117.691 89.454  82.833  1.00 152.81 ? 230 VAL A CG1   1 
ATOM 1695 C CG2   . VAL A 1 230 ? 118.611 87.471  81.641  1.00 154.54 ? 230 VAL A CG2   1 
ATOM 1696 N N     . ILE A 1 231 ? 122.015 87.615  82.193  1.00 156.47 ? 231 ILE A N     1 
ATOM 1697 C CA    . ILE A 1 231 ? 123.050 86.580  82.184  1.00 155.90 ? 231 ILE A CA    1 
ATOM 1698 C C     . ILE A 1 231 ? 123.978 86.753  83.381  1.00 155.74 ? 231 ILE A C     1 
ATOM 1699 O O     . ILE A 1 231 ? 124.242 85.807  84.132  1.00 154.83 ? 231 ILE A O     1 
ATOM 1700 C CB    . ILE A 1 231 ? 123.824 86.609  80.853  1.00 155.73 ? 231 ILE A CB    1 
ATOM 1701 C CG1   . ILE A 1 231 ? 122.939 86.105  79.711  1.00 155.83 ? 231 ILE A CG1   1 
ATOM 1702 C CG2   . ILE A 1 231 ? 125.114 85.793  80.940  1.00 156.57 ? 231 ILE A CG2   1 
ATOM 1703 C CD1   . ILE A 1 231 ? 122.628 84.621  79.784  1.00 155.16 ? 231 ILE A CD1   1 
ATOM 1704 N N     . GLU A 1 232 ? 124.439 87.981  83.613  1.00 154.34 ? 232 GLU A N     1 
ATOM 1705 C CA    . GLU A 1 232 ? 125.258 88.235  84.792  1.00 153.74 ? 232 GLU A CA    1 
ATOM 1706 C C     . GLU A 1 232 ? 124.425 88.212  86.071  1.00 153.17 ? 232 GLU A C     1 
ATOM 1707 O O     . GLU A 1 232 ? 124.970 87.960  87.151  1.00 152.75 ? 232 GLU A O     1 
ATOM 1708 C CB    . GLU A 1 232 ? 126.006 89.561  84.646  1.00 153.91 ? 232 GLU A CB    1 
ATOM 1709 C CG    . GLU A 1 232 ? 126.854 89.685  83.378  1.00 153.58 ? 232 GLU A CG    1 
ATOM 1710 C CD    . GLU A 1 232 ? 126.102 90.297  82.209  1.00 153.67 ? 232 GLU A CD    1 
ATOM 1711 O OE1   . GLU A 1 232 ? 124.910 90.625  82.373  1.00 153.80 ? 232 GLU A OE1   1 
ATOM 1712 O OE2   . GLU A 1 232 ? 126.704 90.446  81.125  1.00 153.67 ? 232 GLU A OE2   1 
ATOM 1713 N N     . PHE A 1 233 ? 123.112 88.450  85.965  1.00 155.01 ? 233 PHE A N     1 
ATOM 1714 C CA    . PHE A 1 233 ? 122.222 88.275  87.112  1.00 155.74 ? 233 PHE A CA    1 
ATOM 1715 C C     . PHE A 1 233 ? 122.139 86.819  87.546  1.00 155.10 ? 233 PHE A C     1 
ATOM 1716 O O     . PHE A 1 233 ? 122.227 86.520  88.741  1.00 154.17 ? 233 PHE A O     1 
ATOM 1717 C CB    . PHE A 1 233 ? 120.826 88.804  86.790  1.00 155.42 ? 233 PHE A CB    1 
ATOM 1718 C CG    . PHE A 1 233 ? 120.610 90.237  87.175  1.00 155.40 ? 233 PHE A CG    1 
ATOM 1719 C CD1   . PHE A 1 233 ? 121.421 90.849  88.122  1.00 154.59 ? 233 PHE A CD1   1 
ATOM 1720 C CD2   . PHE A 1 233 ? 119.597 90.976  86.584  1.00 154.46 ? 233 PHE A CD2   1 
ATOM 1721 C CE1   . PHE A 1 233 ? 121.214 92.166  88.480  1.00 153.12 ? 233 PHE A CE1   1 
ATOM 1722 C CE2   . PHE A 1 233 ? 119.393 92.295  86.933  1.00 153.81 ? 233 PHE A CE2   1 
ATOM 1723 C CZ    . PHE A 1 233 ? 120.206 92.889  87.879  1.00 153.62 ? 233 PHE A CZ    1 
ATOM 1724 N N     . VAL A 1 234 ? 121.994 85.891  86.595  1.00 159.71 ? 234 VAL A N     1 
ATOM 1725 C CA    . VAL A 1 234 ? 121.962 84.484  86.985  1.00 160.52 ? 234 VAL A CA    1 
ATOM 1726 C C     . VAL A 1 234 ? 123.377 83.994  87.296  1.00 161.19 ? 234 VAL A C     1 
ATOM 1727 O O     . VAL A 1 234 ? 123.557 82.965  87.960  1.00 160.68 ? 234 VAL A O     1 
ATOM 1728 C CB    . VAL A 1 234 ? 121.253 83.633  85.904  1.00 159.77 ? 234 VAL A CB    1 
ATOM 1729 C CG1   . VAL A 1 234 ? 122.145 83.363  84.704  1.00 159.18 ? 234 VAL A CG1   1 
ATOM 1730 C CG2   . VAL A 1 234 ? 120.691 82.335  86.487  1.00 159.88 ? 234 VAL A CG2   1 
ATOM 1731 N N     . CYS A 1 235 ? 124.400 84.734  86.852  1.00 162.20 ? 235 CYS A N     1 
ATOM 1732 C CA    . CYS A 1 235 ? 125.764 84.455  87.291  1.00 161.85 ? 235 CYS A CA    1 
ATOM 1733 C C     . CYS A 1 235 ? 125.976 84.819  88.760  1.00 161.58 ? 235 CYS A C     1 
ATOM 1734 O O     . CYS A 1 235 ? 126.641 84.078  89.494  1.00 161.63 ? 235 CYS A O     1 
ATOM 1735 C CB    . CYS A 1 235 ? 126.766 85.206  86.412  1.00 161.25 ? 235 CYS A CB    1 
ATOM 1736 S SG    . CYS A 1 235 ? 127.111 84.449  84.803  1.00 161.67 ? 235 CYS A SG    1 
ATOM 1737 N N     . GLU A 1 236 ? 125.433 85.954  89.212  1.00 155.68 ? 236 GLU A N     1 
ATOM 1738 C CA    . GLU A 1 236 ? 125.818 86.483  90.520  1.00 154.73 ? 236 GLU A CA    1 
ATOM 1739 C C     . GLU A 1 236 ? 124.762 86.301  91.611  1.00 154.71 ? 236 GLU A C     1 
ATOM 1740 O O     . GLU A 1 236 ? 125.120 86.206  92.788  1.00 155.07 ? 236 GLU A O     1 
ATOM 1741 C CB    . GLU A 1 236 ? 126.206 87.970  90.406  1.00 155.06 ? 236 GLU A CB    1 
ATOM 1742 C CG    . GLU A 1 236 ? 125.060 88.971  90.261  1.00 155.17 ? 236 GLU A CG    1 
ATOM 1743 C CD    . GLU A 1 236 ? 125.521 90.320  89.748  1.00 155.58 ? 236 GLU A CD    1 
ATOM 1744 O OE1   . GLU A 1 236 ? 125.924 91.166  90.573  1.00 155.37 ? 236 GLU A OE1   1 
ATOM 1745 O OE2   . GLU A 1 236 ? 125.479 90.537  88.519  1.00 155.60 ? 236 GLU A OE2   1 
ATOM 1746 N N     . VAL A 1 237 ? 123.471 86.241  91.268  1.00 153.02 ? 237 VAL A N     1 
ATOM 1747 C CA    . VAL A 1 237 ? 122.448 86.158  92.312  1.00 153.91 ? 237 VAL A CA    1 
ATOM 1748 C C     . VAL A 1 237 ? 122.271 84.713  92.761  1.00 153.33 ? 237 VAL A C     1 
ATOM 1749 O O     . VAL A 1 237 ? 122.253 84.412  93.961  1.00 152.69 ? 237 VAL A O     1 
ATOM 1750 C CB    . VAL A 1 237 ? 121.123 86.779  91.830  1.00 153.19 ? 237 VAL A CB    1 
ATOM 1751 C CG1   . VAL A 1 237 ? 120.037 86.636  92.887  1.00 153.70 ? 237 VAL A CG1   1 
ATOM 1752 C CG2   . VAL A 1 237 ? 121.325 88.245  91.477  1.00 151.48 ? 237 VAL A CG2   1 
ATOM 1753 N N     . LEU A 1 238 ? 122.167 83.794  91.804  1.00 153.90 ? 238 LEU A N     1 
ATOM 1754 C CA    . LEU A 1 238 ? 122.076 82.374  92.114  1.00 154.29 ? 238 LEU A CA    1 
ATOM 1755 C C     . LEU A 1 238 ? 123.435 81.733  92.361  1.00 155.26 ? 238 LEU A C     1 
ATOM 1756 O O     . LEU A 1 238 ? 123.481 80.538  92.679  1.00 155.01 ? 238 LEU A O     1 
ATOM 1757 C CB    . LEU A 1 238 ? 121.365 81.624  90.979  1.00 155.08 ? 238 LEU A CB    1 
ATOM 1758 C CG    . LEU A 1 238 ? 119.934 82.021  90.607  1.00 154.90 ? 238 LEU A CG    1 
ATOM 1759 C CD1   . LEU A 1 238 ? 119.298 80.940  89.748  1.00 154.23 ? 238 LEU A CD1   1 
ATOM 1760 C CD2   . LEU A 1 238 ? 119.086 82.284  91.843  1.00 154.61 ? 238 LEU A CD2   1 
ATOM 1761 N N     . ASP A 1 239 ? 124.523 82.499  92.197  1.00 156.77 ? 239 ASP A N     1 
ATOM 1762 C CA    . ASP A 1 239 ? 125.921 82.079  92.348  1.00 156.46 ? 239 ASP A CA    1 
ATOM 1763 C C     . ASP A 1 239 ? 126.294 80.928  91.416  1.00 156.13 ? 239 ASP A C     1 
ATOM 1764 O O     . ASP A 1 239 ? 127.180 80.128  91.734  1.00 154.85 ? 239 ASP A O     1 
ATOM 1765 C CB    . ASP A 1 239 ? 126.257 81.719  93.804  1.00 156.36 ? 239 ASP A CB    1 
ATOM 1766 C CG    . ASP A 1 239 ? 126.734 82.916  94.604  1.00 155.92 ? 239 ASP A CG    1 
ATOM 1767 O OD1   . ASP A 1 239 ? 127.159 83.915  93.987  1.00 155.10 ? 239 ASP A OD1   1 
ATOM 1768 O OD2   . ASP A 1 239 ? 126.681 82.858  95.850  1.00 155.77 ? 239 ASP A OD2   1 
ATOM 1769 N N     . PHE A 1 240 ? 125.640 80.843  90.261  1.00 162.34 ? 240 PHE A N     1 
ATOM 1770 C CA    . PHE A 1 240 ? 125.889 79.816  89.253  1.00 163.40 ? 240 PHE A CA    1 
ATOM 1771 C C     . PHE A 1 240 ? 126.341 80.545  87.991  1.00 162.55 ? 240 PHE A C     1 
ATOM 1772 O O     . PHE A 1 240 ? 125.525 80.917  87.146  1.00 161.95 ? 240 PHE A O     1 
ATOM 1773 C CB    . PHE A 1 240 ? 124.637 78.972  88.994  1.00 163.71 ? 240 PHE A CB    1 
ATOM 1774 C CG    . PHE A 1 240 ? 124.529 77.744  89.859  1.00 163.85 ? 240 PHE A CG    1 
ATOM 1775 C CD1   . PHE A 1 240 ? 125.225 77.648  91.057  1.00 163.61 ? 240 PHE A CD1   1 
ATOM 1776 C CD2   . PHE A 1 240 ? 123.723 76.684  89.470  1.00 162.85 ? 240 PHE A CD2   1 
ATOM 1777 C CE1   . PHE A 1 240 ? 125.121 76.517  91.849  1.00 162.92 ? 240 PHE A CE1   1 
ATOM 1778 C CE2   . PHE A 1 240 ? 123.614 75.550  90.256  1.00 162.45 ? 240 PHE A CE2   1 
ATOM 1779 C CZ    . PHE A 1 240 ? 124.314 75.468  91.448  1.00 162.61 ? 240 PHE A CZ    1 
ATOM 1780 N N     . LYS A 1 241 ? 127.653 80.760  87.876  1.00 160.02 ? 241 LYS A N     1 
ATOM 1781 C CA    . LYS A 1 241 ? 128.179 81.511  86.740  1.00 159.41 ? 241 LYS A CA    1 
ATOM 1782 C C     . LYS A 1 241 ? 128.138 80.688  85.459  1.00 159.21 ? 241 LYS A C     1 
ATOM 1783 O O     . LYS A 1 241 ? 127.988 81.242  84.364  1.00 158.73 ? 241 LYS A O     1 
ATOM 1784 C CB    . LYS A 1 241 ? 129.602 81.984  87.033  1.00 160.17 ? 241 LYS A CB    1 
ATOM 1785 C CG    . LYS A 1 241 ? 129.698 82.984  88.174  1.00 159.44 ? 241 LYS A CG    1 
ATOM 1786 C CD    . LYS A 1 241 ? 131.130 83.449  88.383  1.00 159.45 ? 241 LYS A CD    1 
ATOM 1787 C CE    . LYS A 1 241 ? 131.246 84.343  89.605  1.00 160.28 ? 241 LYS A CE    1 
ATOM 1788 N NZ    . LYS A 1 241 ? 132.634 84.847  89.792  1.00 161.14 ? 241 LYS A NZ    1 
ATOM 1789 N N     . SER A 1 242 ? 128.268 79.369  85.573  1.00 163.17 ? 242 SER A N     1 
ATOM 1790 C CA    . SER A 1 242 ? 128.208 78.476  84.427  1.00 163.56 ? 242 SER A CA    1 
ATOM 1791 C C     . SER A 1 242 ? 127.192 77.376  84.689  1.00 163.49 ? 242 SER A C     1 
ATOM 1792 O O     . SER A 1 242 ? 127.125 76.829  85.795  1.00 163.81 ? 242 SER A O     1 
ATOM 1793 C CB    . SER A 1 242 ? 129.580 77.862  84.128  1.00 163.44 ? 242 SER A CB    1 
ATOM 1794 O OG    . SER A 1 242 ? 129.477 76.842  83.151  1.00 161.81 ? 242 SER A OG    1 
ATOM 1795 N N     . ILE A 1 243 ? 126.395 77.058  83.665  1.00 165.30 ? 243 ILE A N     1 
ATOM 1796 C CA    . ILE A 1 243 ? 125.447 75.951  83.752  1.00 166.08 ? 243 ILE A CA    1 
ATOM 1797 C C     . ILE A 1 243 ? 126.047 74.651  83.230  1.00 165.56 ? 243 ILE A C     1 
ATOM 1798 O O     . ILE A 1 243 ? 125.442 73.580  83.407  1.00 164.22 ? 243 ILE A O     1 
ATOM 1799 C CB    . ILE A 1 243 ? 124.144 76.328  83.010  1.00 165.82 ? 243 ILE A CB    1 
ATOM 1800 C CG1   . ILE A 1 243 ? 122.926 75.661  83.661  1.00 166.01 ? 243 ILE A CG1   1 
ATOM 1801 C CG2   . ILE A 1 243 ? 124.237 76.016  81.513  1.00 165.43 ? 243 ILE A CG2   1 
ATOM 1802 C CD1   . ILE A 1 243 ? 122.520 76.284  84.980  1.00 165.20 ? 243 ILE A CD1   1 
ATOM 1803 N N     . GLU A 1 244 ? 127.233 74.708  82.617  1.00 168.40 ? 244 GLU A N     1 
ATOM 1804 C CA    . GLU A 1 244 ? 127.868 73.507  82.084  1.00 168.03 ? 244 GLU A CA    1 
ATOM 1805 C C     . GLU A 1 244 ? 128.380 72.605  83.201  1.00 168.45 ? 244 GLU A C     1 
ATOM 1806 O O     . GLU A 1 244 ? 128.414 71.377  83.051  1.00 167.85 ? 244 GLU A O     1 
ATOM 1807 C CB    . GLU A 1 244 ? 129.007 73.901  81.145  1.00 168.25 ? 244 GLU A CB    1 
ATOM 1808 C CG    . GLU A 1 244 ? 128.573 74.793  79.992  1.00 167.93 ? 244 GLU A CG    1 
ATOM 1809 C CD    . GLU A 1 244 ? 129.738 75.247  79.134  1.00 167.98 ? 244 GLU A CD    1 
ATOM 1810 O OE1   . GLU A 1 244 ? 130.893 74.910  79.467  1.00 167.79 ? 244 GLU A OE1   1 
ATOM 1811 O OE2   . GLU A 1 244 ? 129.497 75.946  78.127  1.00 168.04 ? 244 GLU A OE2   1 
ATOM 1812 N N     . GLU A 1 245 ? 128.792 73.195  84.326  1.00 170.87 ? 245 GLU A N     1 
ATOM 1813 C CA    . GLU A 1 245 ? 129.230 72.390  85.462  1.00 170.44 ? 245 GLU A CA    1 
ATOM 1814 C C     . GLU A 1 245 ? 128.045 71.739  86.165  1.00 170.03 ? 245 GLU A C     1 
ATOM 1815 O O     . GLU A 1 245 ? 128.176 70.652  86.741  1.00 170.37 ? 245 GLU A O     1 
ATOM 1816 C CB    . GLU A 1 245 ? 130.041 73.249  86.435  1.00 169.01 ? 245 GLU A CB    1 
ATOM 1817 C CG    . GLU A 1 245 ? 129.427 74.605  86.743  1.00 169.45 ? 245 GLU A CG    1 
ATOM 1818 C CD    . GLU A 1 245 ? 128.732 74.645  88.090  1.00 169.58 ? 245 GLU A CD    1 
ATOM 1819 O OE1   . GLU A 1 245 ? 128.835 73.655  88.844  1.00 169.18 ? 245 GLU A OE1   1 
ATOM 1820 O OE2   . GLU A 1 245 ? 128.084 75.668  88.394  1.00 168.97 ? 245 GLU A OE2   1 
ATOM 1821 N N     . GLN A 1 246 ? 126.880 72.387  86.131  1.00 167.82 ? 246 GLN A N     1 
ATOM 1822 C CA    . GLN A 1 246 ? 125.650 71.803  86.666  1.00 167.51 ? 246 GLN A CA    1 
ATOM 1823 C C     . GLN A 1 246 ? 124.957 71.012  85.556  1.00 167.61 ? 246 GLN A C     1 
ATOM 1824 O O     . GLN A 1 246 ? 123.995 71.455  84.925  1.00 168.10 ? 246 GLN A O     1 
ATOM 1825 C CB    . GLN A 1 246 ? 124.746 72.884  87.245  1.00 167.47 ? 246 GLN A CB    1 
ATOM 1826 C CG    . GLN A 1 246 ? 123.613 72.350  88.113  1.00 168.39 ? 246 GLN A CG    1 
ATOM 1827 C CD    . GLN A 1 246 ? 124.089 71.878  89.473  1.00 168.16 ? 246 GLN A CD    1 
ATOM 1828 O OE1   . GLN A 1 246 ? 124.882 72.546  90.134  1.00 167.85 ? 246 GLN A OE1   1 
ATOM 1829 N NE2   . GLN A 1 246 ? 123.605 70.716  89.898  1.00 167.80 ? 246 GLN A NE2   1 
ATOM 1830 N N     . GLN A 1 247 ? 125.494 69.813  85.309  1.00 168.34 ? 247 GLN A N     1 
ATOM 1831 C CA    . GLN A 1 247 ? 124.923 68.936  84.291  1.00 168.51 ? 247 GLN A CA    1 
ATOM 1832 C C     . GLN A 1 247 ? 123.586 68.363  84.742  1.00 168.45 ? 247 GLN A C     1 
ATOM 1833 O O     . GLN A 1 247 ? 122.615 68.353  83.976  1.00 168.25 ? 247 GLN A O     1 
ATOM 1834 C CB    . GLN A 1 247 ? 125.903 67.809  83.964  1.00 169.12 ? 247 GLN A CB    1 
ATOM 1835 C CG    . GLN A 1 247 ? 127.122 68.248  83.173  1.00 168.40 ? 247 GLN A CG    1 
ATOM 1836 C CD    . GLN A 1 247 ? 127.733 67.115  82.374  1.00 168.80 ? 247 GLN A CD    1 
ATOM 1837 O OE1   . GLN A 1 247 ? 127.239 65.988  82.395  1.00 168.86 ? 247 GLN A OE1   1 
ATOM 1838 N NE2   . GLN A 1 247 ? 128.816 67.409  81.663  1.00 169.00 ? 247 GLN A NE2   1 
ATOM 1839 N N     . LYS A 1 248 ? 123.517 67.882  85.980  1.00 167.01 ? 248 LYS A N     1 
ATOM 1840 C CA    . LYS A 1 248 ? 122.270 67.375  86.535  1.00 167.12 ? 248 LYS A CA    1 
ATOM 1841 C C     . LYS A 1 248 ? 121.432 68.540  87.040  1.00 167.30 ? 248 LYS A C     1 
ATOM 1842 O O     . LYS A 1 248 ? 121.948 69.373  87.799  1.00 167.91 ? 248 LYS A O     1 
ATOM 1843 C CB    . LYS A 1 248 ? 122.542 66.396  87.667  1.00 166.68 ? 248 LYS A CB    1 
ATOM 1844 C CG    . LYS A 1 248 ? 123.251 65.097  87.261  1.00 166.77 ? 248 LYS A CG    1 
ATOM 1845 C CD    . LYS A 1 248 ? 122.792 64.559  85.907  1.00 168.07 ? 248 LYS A CD    1 
ATOM 1846 C CE    . LYS A 1 248 ? 121.570 63.666  86.054  1.00 167.61 ? 248 LYS A CE    1 
ATOM 1847 N NZ    . LYS A 1 248 ? 120.967 63.329  84.735  1.00 167.06 ? 248 LYS A NZ    1 
ATOM 1848 N N     . PRO A 1 249 ? 120.167 68.659  86.631  1.00 171.65 ? 249 PRO A N     1 
ATOM 1849 C CA    . PRO A 1 249 ? 119.338 69.774  87.106  1.00 171.84 ? 249 PRO A CA    1 
ATOM 1850 C C     . PRO A 1 249 ? 118.971 69.617  88.574  1.00 172.34 ? 249 PRO A C     1 
ATOM 1851 O O     . PRO A 1 249 ? 118.944 68.512  89.120  1.00 172.97 ? 249 PRO A O     1 
ATOM 1852 C CB    . PRO A 1 249 ? 118.093 69.704  86.211  1.00 172.47 ? 249 PRO A CB    1 
ATOM 1853 C CG    . PRO A 1 249 ? 118.451 68.770  85.086  1.00 172.37 ? 249 PRO A CG    1 
ATOM 1854 C CD    . PRO A 1 249 ? 119.461 67.826  85.646  1.00 172.00 ? 249 PRO A CD    1 
ATOM 1855 N N     . LEU A 1 250 ? 118.689 70.749  89.212  1.00 173.65 ? 250 LEU A N     1 
ATOM 1856 C CA    . LEU A 1 250 ? 118.344 70.775  90.626  1.00 174.15 ? 250 LEU A CA    1 
ATOM 1857 C C     . LEU A 1 250 ? 116.856 70.470  90.806  1.00 174.57 ? 250 LEU A C     1 
ATOM 1858 O O     . LEU A 1 250 ? 116.160 70.047  89.879  1.00 173.90 ? 250 LEU A O     1 
ATOM 1859 C CB    . LEU A 1 250 ? 118.728 72.120  91.236  1.00 174.02 ? 250 LEU A CB    1 
ATOM 1860 C CG    . LEU A 1 250 ? 120.212 72.489  91.205  1.00 173.37 ? 250 LEU A CG    1 
ATOM 1861 C CD1   . LEU A 1 250 ? 120.420 73.914  91.685  1.00 173.13 ? 250 LEU A CD1   1 
ATOM 1862 C CD2   . LEU A 1 250 ? 121.017 71.518  92.051  1.00 173.39 ? 250 LEU A CD2   1 
ATOM 1863 N N     . THR A 1 251 ? 116.350 70.697  92.015  1.00 177.88 ? 251 THR A N     1 
ATOM 1864 C CA    . THR A 1 251 ? 114.967 70.408  92.362  1.00 177.08 ? 251 THR A CA    1 
ATOM 1865 C C     . THR A 1 251 ? 114.055 71.549  91.905  1.00 176.55 ? 251 THR A C     1 
ATOM 1866 O O     . THR A 1 251 ? 114.435 72.401  91.098  1.00 176.72 ? 251 THR A O     1 
ATOM 1867 C CB    . THR A 1 251 ? 114.845 70.156  93.864  1.00 177.49 ? 251 THR A CB    1 
ATOM 1868 O OG1   . THR A 1 251 ? 115.399 71.265  94.584  1.00 177.31 ? 251 THR A OG1   1 
ATOM 1869 C CG2   . THR A 1 251 ? 115.589 68.888  94.250  1.00 176.65 ? 251 THR A CG2   1 
ATOM 1870 N N     . ASP A 1 252 ? 112.820 71.566  92.413  1.00 170.44 ? 252 ASP A N     1 
ATOM 1871 C CA    . ASP A 1 252 ? 111.865 72.601  92.031  1.00 169.85 ? 252 ASP A CA    1 
ATOM 1872 C C     . ASP A 1 252 ? 112.107 73.926  92.746  1.00 168.48 ? 252 ASP A C     1 
ATOM 1873 O O     . ASP A 1 252 ? 111.470 74.924  92.388  1.00 168.46 ? 252 ASP A O     1 
ATOM 1874 C CB    . ASP A 1 252 ? 110.438 72.123  92.309  1.00 170.12 ? 252 ASP A CB    1 
ATOM 1875 C CG    . ASP A 1 252 ? 109.826 71.395  91.130  1.00 169.76 ? 252 ASP A CG    1 
ATOM 1876 O OD1   . ASP A 1 252 ? 110.185 71.718  89.978  1.00 169.68 ? 252 ASP A OD1   1 
ATOM 1877 O OD2   . ASP A 1 252 ? 108.986 70.499  91.353  1.00 169.20 ? 252 ASP A OD2   1 
ATOM 1878 N N     . SER A 1 253 ? 113.006 73.953  93.738  1.00 167.10 ? 253 SER A N     1 
ATOM 1879 C CA    . SER A 1 253 ? 113.216 75.150  94.551  1.00 168.16 ? 253 SER A CA    1 
ATOM 1880 C C     . SER A 1 253 ? 113.835 76.285  93.742  1.00 168.29 ? 253 SER A C     1 
ATOM 1881 O O     . SER A 1 253 ? 113.476 77.455  93.930  1.00 167.39 ? 253 SER A O     1 
ATOM 1882 C CB    . SER A 1 253 ? 114.094 74.813  95.756  1.00 168.46 ? 253 SER A CB    1 
ATOM 1883 O OG    . SER A 1 253 ? 114.444 75.983  96.476  1.00 168.24 ? 253 SER A OG    1 
ATOM 1884 N N     . GLN A 1 254 ? 114.750 75.959  92.824  1.00 169.38 ? 254 GLN A N     1 
ATOM 1885 C CA    . GLN A 1 254 ? 115.323 76.985  91.957  1.00 169.01 ? 254 GLN A CA    1 
ATOM 1886 C C     . GLN A 1 254 ? 114.292 77.502  90.960  1.00 169.52 ? 254 GLN A C     1 
ATOM 1887 O O     . GLN A 1 254 ? 114.324 78.677  90.585  1.00 169.22 ? 254 GLN A O     1 
ATOM 1888 C CB    . GLN A 1 254 ? 116.552 76.443  91.227  1.00 168.24 ? 254 GLN A CB    1 
ATOM 1889 C CG    . GLN A 1 254 ? 116.403 75.024  90.724  1.00 168.42 ? 254 GLN A CG    1 
ATOM 1890 C CD    . GLN A 1 254 ? 115.956 74.964  89.278  1.00 167.82 ? 254 GLN A CD    1 
ATOM 1891 O OE1   . GLN A 1 254 ? 116.105 75.929  88.529  1.00 167.12 ? 254 GLN A OE1   1 
ATOM 1892 N NE2   . GLN A 1 254 ? 115.399 73.827  88.879  1.00 168.09 ? 254 GLN A NE2   1 
ATOM 1893 N N     . ARG A 1 255 ? 113.353 76.645  90.544  1.00 170.49 ? 255 ARG A N     1 
ATOM 1894 C CA    . ARG A 1 255 ? 112.262 77.082  89.673  1.00 169.48 ? 255 ARG A CA    1 
ATOM 1895 C C     . ARG A 1 255 ? 111.312 78.033  90.399  1.00 170.23 ? 255 ARG A C     1 
ATOM 1896 O O     . ARG A 1 255 ? 110.889 79.053  89.837  1.00 170.97 ? 255 ARG A O     1 
ATOM 1897 C CB    . ARG A 1 255 ? 111.514 75.858  89.137  1.00 169.11 ? 255 ARG A CB    1 
ATOM 1898 C CG    . ARG A 1 255 ? 110.124 76.132  88.573  1.00 168.87 ? 255 ARG A CG    1 
ATOM 1899 C CD    . ARG A 1 255 ? 110.179 76.621  87.133  1.00 169.26 ? 255 ARG A CD    1 
ATOM 1900 N NE    . ARG A 1 255 ? 109.047 77.482  86.810  1.00 169.14 ? 255 ARG A NE    1 
ATOM 1901 C CZ    . ARG A 1 255 ? 108.274 77.336  85.743  1.00 169.13 ? 255 ARG A CZ    1 
ATOM 1902 N NH1   . ARG A 1 255 ? 108.488 76.374  84.860  1.00 168.43 ? 255 ARG A NH1   1 
ATOM 1903 N NH2   . ARG A 1 255 ? 107.259 78.176  85.557  1.00 169.06 ? 255 ARG A NH2   1 
ATOM 1904 N N     . VAL A 1 256 ? 110.989 77.728  91.659  1.00 166.03 ? 256 VAL A N     1 
ATOM 1905 C CA    . VAL A 1 256 ? 110.106 78.599  92.436  1.00 165.00 ? 256 VAL A CA    1 
ATOM 1906 C C     . VAL A 1 256 ? 110.808 79.918  92.769  1.00 164.93 ? 256 VAL A C     1 
ATOM 1907 O O     . VAL A 1 256 ? 110.192 80.991  92.729  1.00 165.37 ? 256 VAL A O     1 
ATOM 1908 C CB    . VAL A 1 256 ? 109.600 77.854  93.691  1.00 164.94 ? 256 VAL A CB    1 
ATOM 1909 C CG1   . VAL A 1 256 ? 108.718 78.734  94.552  1.00 165.30 ? 256 VAL A CG1   1 
ATOM 1910 C CG2   . VAL A 1 256 ? 108.804 76.628  93.280  1.00 165.55 ? 256 VAL A CG2   1 
ATOM 1911 N N     . LYS A 1 257 ? 112.119 79.870  93.037  1.00 165.16 ? 257 LYS A N     1 
ATOM 1912 C CA    . LYS A 1 257 ? 112.877 81.101  93.267  1.00 166.18 ? 257 LYS A CA    1 
ATOM 1913 C C     . LYS A 1 257 ? 113.030 81.917  91.984  1.00 165.42 ? 257 LYS A C     1 
ATOM 1914 O O     . LYS A 1 257 ? 113.076 83.153  92.029  1.00 165.68 ? 257 LYS A O     1 
ATOM 1915 C CB    . LYS A 1 257 ? 114.246 80.773  93.861  1.00 165.77 ? 257 LYS A CB    1 
ATOM 1916 C CG    . LYS A 1 257 ? 114.810 81.873  94.745  1.00 164.34 ? 257 LYS A CG    1 
ATOM 1917 C CD    . LYS A 1 257 ? 115.928 82.633  94.049  1.00 165.18 ? 257 LYS A CD    1 
ATOM 1918 C CE    . LYS A 1 257 ? 116.777 83.402  95.050  1.00 165.19 ? 257 LYS A CE    1 
ATOM 1919 N NZ    . LYS A 1 257 ? 117.809 84.244  94.382  1.00 165.17 ? 257 LYS A NZ    1 
ATOM 1920 N N     . PHE A 1 258 ? 113.111 81.237  90.834  1.00 165.76 ? 258 PHE A N     1 
ATOM 1921 C CA    . PHE A 1 258 ? 113.067 81.900  89.532  1.00 165.76 ? 258 PHE A CA    1 
ATOM 1922 C C     . PHE A 1 258 ? 111.742 82.623  89.337  1.00 165.71 ? 258 PHE A C     1 
ATOM 1923 O O     . PHE A 1 258 ? 111.703 83.754  88.836  1.00 165.24 ? 258 PHE A O     1 
ATOM 1924 C CB    . PHE A 1 258 ? 113.274 80.856  88.431  1.00 166.78 ? 258 PHE A CB    1 
ATOM 1925 C CG    . PHE A 1 258 ? 113.834 81.404  87.150  1.00 167.11 ? 258 PHE A CG    1 
ATOM 1926 C CD1   . PHE A 1 258 ? 115.204 81.552  86.979  1.00 167.00 ? 258 PHE A CD1   1 
ATOM 1927 C CD2   . PHE A 1 258 ? 112.986 81.753  86.105  1.00 167.08 ? 258 PHE A CD2   1 
ATOM 1928 C CE1   . PHE A 1 258 ? 115.720 82.046  85.791  1.00 166.91 ? 258 PHE A CE1   1 
ATOM 1929 C CE2   . PHE A 1 258 ? 113.492 82.251  84.917  1.00 166.95 ? 258 PHE A CE2   1 
ATOM 1930 C CZ    . PHE A 1 258 ? 114.861 82.399  84.760  1.00 166.55 ? 258 PHE A CZ    1 
ATOM 1931 N N     . THR A 1 259 ? 110.646 81.978  89.749  1.00 167.26 ? 259 THR A N     1 
ATOM 1932 C CA    . THR A 1 259 ? 109.322 82.588  89.666  1.00 167.94 ? 259 THR A CA    1 
ATOM 1933 C C     . THR A 1 259 ? 109.193 83.783  90.612  1.00 167.75 ? 259 THR A C     1 
ATOM 1934 O O     . THR A 1 259 ? 108.503 84.760  90.295  1.00 167.82 ? 259 THR A O     1 
ATOM 1935 C CB    . THR A 1 259 ? 108.253 81.534  89.968  1.00 166.56 ? 259 THR A CB    1 
ATOM 1936 O OG1   . THR A 1 259 ? 108.574 80.322  89.273  1.00 166.33 ? 259 THR A OG1   1 
ATOM 1937 C CG2   . THR A 1 259 ? 106.874 82.002  89.520  1.00 165.43 ? 259 THR A CG2   1 
ATOM 1938 N N     . LYS A 1 260 ? 109.842 83.719  91.781  1.00 161.02 ? 260 LYS A N     1 
ATOM 1939 C CA    . LYS A 1 260 ? 109.842 84.868  92.690  1.00 160.10 ? 260 LYS A CA    1 
ATOM 1940 C C     . LYS A 1 260 ? 110.628 86.043  92.116  1.00 160.17 ? 260 LYS A C     1 
ATOM 1941 O O     . LYS A 1 260 ? 110.124 87.170  92.052  1.00 160.76 ? 260 LYS A O     1 
ATOM 1942 C CB    . LYS A 1 260 ? 110.424 84.503  94.058  1.00 159.34 ? 260 LYS A CB    1 
ATOM 1943 C CG    . LYS A 1 260 ? 109.718 83.431  94.856  1.00 159.63 ? 260 LYS A CG    1 
ATOM 1944 C CD    . LYS A 1 260 ? 110.656 82.935  95.950  1.00 159.34 ? 260 LYS A CD    1 
ATOM 1945 C CE    . LYS A 1 260 ? 110.399 81.494  96.326  1.00 159.60 ? 260 LYS A CE    1 
ATOM 1946 N NZ    . LYS A 1 260 ? 109.359 81.360  97.380  1.00 158.31 ? 260 LYS A NZ    1 
ATOM 1947 N N     . GLU A 1 261 ? 111.867 85.797  91.686  1.00 162.54 ? 261 GLU A N     1 
ATOM 1948 C CA    . GLU A 1 261 ? 112.782 86.900  91.410  1.00 162.76 ? 261 GLU A CA    1 
ATOM 1949 C C     . GLU A 1 261 ? 112.692 87.427  89.982  1.00 162.34 ? 261 GLU A C     1 
ATOM 1950 O O     . GLU A 1 261 ? 112.719 88.644  89.776  1.00 162.11 ? 261 GLU A O     1 
ATOM 1951 C CB    . GLU A 1 261 ? 114.223 86.477  91.722  1.00 161.89 ? 261 GLU A CB    1 
ATOM 1952 C CG    . GLU A 1 261 ? 114.424 85.956  93.134  1.00 162.29 ? 261 GLU A CG    1 
ATOM 1953 C CD    . GLU A 1 261 ? 113.910 86.917  94.190  1.00 163.22 ? 261 GLU A CD    1 
ATOM 1954 O OE1   . GLU A 1 261 ? 114.280 88.111  94.143  1.00 163.41 ? 261 GLU A OE1   1 
ATOM 1955 O OE2   . GLU A 1 261 ? 113.128 86.483  95.062  1.00 162.81 ? 261 GLU A OE2   1 
ATOM 1956 N N     . ILE A 1 262 ? 112.601 86.534  88.992  1.00 162.03 ? 262 ILE A N     1 
ATOM 1957 C CA    . ILE A 1 262 ? 112.713 86.949  87.595  1.00 161.89 ? 262 ILE A CA    1 
ATOM 1958 C C     . ILE A 1 262 ? 111.453 87.684  87.145  1.00 161.59 ? 262 ILE A C     1 
ATOM 1959 O O     . ILE A 1 262 ? 111.523 88.662  86.388  1.00 160.82 ? 262 ILE A O     1 
ATOM 1960 C CB    . ILE A 1 262 ? 113.027 85.724  86.716  1.00 162.16 ? 262 ILE A CB    1 
ATOM 1961 C CG1   . ILE A 1 262 ? 114.315 85.067  87.207  1.00 161.80 ? 262 ILE A CG1   1 
ATOM 1962 C CG2   . ILE A 1 262 ? 113.196 86.106  85.252  1.00 161.32 ? 262 ILE A CG2   1 
ATOM 1963 C CD1   . ILE A 1 262 ? 115.544 85.943  87.077  1.00 161.05 ? 262 ILE A CD1   1 
ATOM 1964 N N     . LYS A 1 263 ? 110.290 87.249  87.628  1.00 159.48 ? 263 LYS A N     1 
ATOM 1965 C CA    . LYS A 1 263 ? 109.033 87.894  87.268  1.00 158.80 ? 263 LYS A CA    1 
ATOM 1966 C C     . LYS A 1 263 ? 108.919 89.265  87.927  1.00 156.74 ? 263 LYS A C     1 
ATOM 1967 O O     . LYS A 1 263 ? 109.162 89.414  89.128  1.00 156.43 ? 263 LYS A O     1 
ATOM 1968 C CB    . LYS A 1 263 ? 107.855 87.013  87.684  1.00 159.45 ? 263 LYS A CB    1 
ATOM 1969 C CG    . LYS A 1 263 ? 106.523 87.425  87.082  1.00 158.88 ? 263 LYS A CG    1 
ATOM 1970 C CD    . LYS A 1 263 ? 105.405 86.506  87.543  1.00 158.00 ? 263 LYS A CD    1 
ATOM 1971 C CE    . LYS A 1 263 ? 105.627 85.084  87.059  1.00 157.60 ? 263 LYS A CE    1 
ATOM 1972 N NZ    . LYS A 1 263 ? 104.412 84.238  87.216  1.00 158.92 ? 263 LYS A NZ    1 
ATOM 1973 N N     . GLY A 1 264 ? 108.547 90.268  87.131  1.00 149.90 ? 264 GLY A N     1 
ATOM 1974 C CA    . GLY A 1 264 ? 108.382 91.623  87.613  1.00 150.16 ? 264 GLY A CA    1 
ATOM 1975 C C     . GLY A 1 264 ? 109.507 92.577  87.273  1.00 150.10 ? 264 GLY A C     1 
ATOM 1976 O O     . GLY A 1 264 ? 109.441 93.748  87.666  1.00 149.32 ? 264 GLY A O     1 
ATOM 1977 N N     . LEU A 1 265 ? 110.531 92.123  86.558  1.00 150.34 ? 265 LEU A N     1 
ATOM 1978 C CA    . LEU A 1 265 ? 111.646 92.967  86.148  1.00 149.51 ? 265 LEU A CA    1 
ATOM 1979 C C     . LEU A 1 265 ? 111.584 93.136  84.636  1.00 150.48 ? 265 LEU A C     1 
ATOM 1980 O O     . LEU A 1 265 ? 111.611 92.146  83.899  1.00 150.33 ? 265 LEU A O     1 
ATOM 1981 C CB    . LEU A 1 265 ? 112.983 92.360  86.574  1.00 148.74 ? 265 LEU A CB    1 
ATOM 1982 C CG    . LEU A 1 265 ? 113.055 91.585  87.894  1.00 149.56 ? 265 LEU A CG    1 
ATOM 1983 C CD1   . LEU A 1 265 ? 114.412 90.925  88.021  1.00 149.63 ? 265 LEU A CD1   1 
ATOM 1984 C CD2   . LEU A 1 265 ? 112.803 92.494  89.089  1.00 149.29 ? 265 LEU A CD2   1 
ATOM 1985 N N     . LYS A 1 266 ? 111.519 94.384  84.180  1.00 146.69 ? 266 LYS A N     1 
ATOM 1986 C CA    . LYS A 1 266 ? 111.289 94.653  82.767  1.00 146.44 ? 266 LYS A CA    1 
ATOM 1987 C C     . LYS A 1 266 ? 112.559 94.442  81.952  1.00 146.30 ? 266 LYS A C     1 
ATOM 1988 O O     . LYS A 1 266 ? 113.636 94.929  82.308  1.00 145.29 ? 266 LYS A O     1 
ATOM 1989 C CB    . LYS A 1 266 ? 110.779 96.083  82.573  1.00 146.58 ? 266 LYS A CB    1 
ATOM 1990 C CG    . LYS A 1 266 ? 109.481 96.425  83.301  1.00 146.51 ? 266 LYS A CG    1 
ATOM 1991 C CD    . LYS A 1 266 ? 108.410 95.357  83.130  1.00 146.75 ? 266 LYS A CD    1 
ATOM 1992 C CE    . LYS A 1 266 ? 107.426 95.364  84.292  1.00 146.16 ? 266 LYS A CE    1 
ATOM 1993 N NZ    . LYS A 1 266 ? 106.556 94.154  84.305  1.00 144.85 ? 266 LYS A NZ    1 
ATOM 1994 N N     . VAL A 1 267 ? 112.426 93.705  80.850  1.00 155.89 ? 267 VAL A N     1 
ATOM 1995 C CA    . VAL A 1 267 ? 113.519 93.489  79.908  1.00 155.30 ? 267 VAL A CA    1 
ATOM 1996 C C     . VAL A 1 267 ? 113.152 94.109  78.563  1.00 154.63 ? 267 VAL A C     1 
ATOM 1997 O O     . VAL A 1 267 ? 112.028 94.586  78.372  1.00 156.58 ? 267 VAL A O     1 
ATOM 1998 C CB    . VAL A 1 267 ? 113.842 91.992  79.751  1.00 155.01 ? 267 VAL A CB    1 
ATOM 1999 C CG1   . VAL A 1 267 ? 114.108 91.354  81.103  1.00 155.20 ? 267 VAL A CG1   1 
ATOM 2000 C CG2   . VAL A 1 267 ? 112.705 91.289  79.046  1.00 155.16 ? 267 VAL A CG2   1 
ATOM 2001 N N     . GLU A 1 268 ? 114.093 94.096  77.621  1.00 147.68 ? 268 GLU A N     1 
ATOM 2002 C CA    . GLU A 1 268 ? 113.861 94.655  76.296  1.00 149.37 ? 268 GLU A CA    1 
ATOM 2003 C C     . GLU A 1 268 ? 114.708 93.898  75.284  1.00 149.81 ? 268 GLU A C     1 
ATOM 2004 O O     . GLU A 1 268 ? 115.609 93.136  75.645  1.00 148.04 ? 268 GLU A O     1 
ATOM 2005 C CB    . GLU A 1 268 ? 114.180 96.154  76.246  1.00 149.30 ? 268 GLU A CB    1 
ATOM 2006 C CG    . GLU A 1 268 ? 115.663 96.469  76.138  1.00 148.62 ? 268 GLU A CG    1 
ATOM 2007 C CD    . GLU A 1 268 ? 115.930 97.801  75.468  1.00 146.76 ? 268 GLU A CD    1 
ATOM 2008 O OE1   . GLU A 1 268 ? 114.957 98.525  75.171  1.00 145.92 ? 268 GLU A OE1   1 
ATOM 2009 O OE2   . GLU A 1 268 ? 117.114 98.123  75.234  1.00 146.21 ? 268 GLU A OE2   1 
ATOM 2010 N N     . ILE A 1 269 ? 114.399 94.110  74.002  1.00 153.60 ? 269 ILE A N     1 
ATOM 2011 C CA    . ILE A 1 269 ? 115.104 93.447  72.911  1.00 152.21 ? 269 ILE A CA    1 
ATOM 2012 C C     . ILE A 1 269 ? 116.198 94.361  72.380  1.00 151.04 ? 269 ILE A C     1 
ATOM 2013 O O     . ILE A 1 269 ? 116.167 95.587  72.554  1.00 151.70 ? 269 ILE A O     1 
ATOM 2014 C CB    . ILE A 1 269 ? 114.138 93.004  71.787  1.00 152.34 ? 269 ILE A CB    1 
ATOM 2015 C CG1   . ILE A 1 269 ? 113.904 94.114  70.757  1.00 150.42 ? 269 ILE A CG1   1 
ATOM 2016 C CG2   . ILE A 1 269 ? 112.825 92.540  72.368  1.00 152.76 ? 269 ILE A CG2   1 
ATOM 2017 C CD1   . ILE A 1 269 ? 113.306 93.623  69.466  1.00 150.85 ? 269 ILE A CD1   1 
ATOM 2018 N N     . THR A 1 270 ? 117.212 93.757  71.756  1.00 160.11 ? 270 THR A N     1 
ATOM 2019 C CA    . THR A 1 270 ? 118.304 94.547  71.140  1.00 161.94 ? 270 THR A CA    1 
ATOM 2020 C C     . THR A 1 270 ? 118.688 93.846  69.861  1.00 161.95 ? 270 THR A C     1 
ATOM 2021 O O     . THR A 1 270 ? 119.707 94.237  69.253  1.00 162.31 ? 270 THR A O     1 
ATOM 2022 C CB    . THR A 1 270 ? 119.501 94.652  72.083  1.00 162.24 ? 270 THR A CB    1 
ATOM 2023 O OG1   . THR A 1 270 ? 119.570 93.392  72.744  1.00 162.09 ? 270 THR A OG1   1 
ATOM 2024 C CG2   . THR A 1 270 ? 119.367 95.783  73.089  1.00 161.82 ? 270 THR A CG2   1 
ATOM 2025 N N     . HIS A 1 271 ? 117.903 92.843  69.462  1.00 162.19 ? 271 HIS A N     1 
ATOM 2026 C CA    . HIS A 1 271 ? 118.239 92.031  68.264  1.00 161.90 ? 271 HIS A CA    1 
ATOM 2027 C C     . HIS A 1 271 ? 117.339 92.441  67.096  1.00 162.22 ? 271 HIS A C     1 
ATOM 2028 O O     . HIS A 1 271 ? 116.861 91.555  66.355  1.00 163.46 ? 271 HIS A O     1 
ATOM 2029 C CB    . HIS A 1 271 ? 118.067 90.547  68.596  1.00 162.02 ? 271 HIS A CB    1 
ATOM 2030 C CG    . HIS A 1 271 ? 116.980 90.305  69.590  1.00 162.20 ? 271 HIS A CG    1 
ATOM 2031 N ND1   . HIS A 1 271 ? 117.196 90.271  70.951  1.00 162.39 ? 271 HIS A ND1   1 
ATOM 2032 C CD2   . HIS A 1 271 ? 115.668 90.103  69.419  1.00 162.10 ? 271 HIS A CD2   1 
ATOM 2033 C CE1   . HIS A 1 271 ? 116.046 90.049  71.569  1.00 162.12 ? 271 HIS A CE1   1 
ATOM 2034 N NE2   . HIS A 1 271 ? 115.105 89.939  70.658  1.00 162.23 ? 271 HIS A NE2   1 
ATOM 2035 N N     . CYS A 1 272 ? 117.114 93.748  66.937  1.00 157.75 ? 272 CYS A N     1 
ATOM 2036 C CA    . CYS A 1 272 ? 116.272 94.240  65.814  1.00 157.72 ? 272 CYS A CA    1 
ATOM 2037 C C     . CYS A 1 272 ? 116.889 95.513  65.217  1.00 157.60 ? 272 CYS A C     1 
ATOM 2038 O O     . CYS A 1 272 ? 116.118 96.356  64.705  1.00 157.76 ? 272 CYS A O     1 
ATOM 2039 C CB    . CYS A 1 272 ? 114.833 94.456  66.268  1.00 157.98 ? 272 CYS A CB    1 
ATOM 2040 S SG    . CYS A 1 272 ? 113.775 93.018  65.955  1.00 158.62 ? 272 CYS A SG    1 
ATOM 2041 N N     . GLY A 1 273 ? 118.216 95.653  65.288  1.00 163.93 ? 273 GLY A N     1 
ATOM 2042 C CA    . GLY A 1 273 ? 118.865 96.785  64.646  1.00 165.05 ? 273 GLY A CA    1 
ATOM 2043 C C     . GLY A 1 273 ? 118.520 98.092  65.328  1.00 165.36 ? 273 GLY A C     1 
ATOM 2044 O O     . GLY A 1 273 ? 118.502 98.195  66.559  1.00 165.10 ? 273 GLY A O     1 
ATOM 2045 N N     . GLN A 1 274 ? 118.243 99.113  64.513  1.00 157.23 ? 274 GLN A N     1 
ATOM 2046 C CA    . GLN A 1 274 ? 117.876 100.430 65.018  1.00 155.70 ? 274 GLN A CA    1 
ATOM 2047 C C     . GLN A 1 274 ? 116.475 100.465 65.615  1.00 154.48 ? 274 GLN A C     1 
ATOM 2048 O O     . GLN A 1 274 ? 116.176 101.374 66.398  1.00 154.63 ? 274 GLN A O     1 
ATOM 2049 C CB    . GLN A 1 274 ? 117.978 101.461 63.893  1.00 154.93 ? 274 GLN A CB    1 
ATOM 2050 C CG    . GLN A 1 274 ? 119.205 101.297 63.013  1.00 155.01 ? 274 GLN A CG    1 
ATOM 2051 C CD    . GLN A 1 274 ? 118.956 101.739 61.584  1.00 155.83 ? 274 GLN A CD    1 
ATOM 2052 O OE1   . GLN A 1 274 ? 117.841 102.117 61.226  1.00 156.83 ? 274 GLN A OE1   1 
ATOM 2053 N NE2   . GLN A 1 274 ? 119.995 101.693 60.759  1.00 155.78 ? 274 GLN A NE2   1 
ATOM 2054 N N     . MET A 1 275 ? 115.619 99.508  65.267  1.00 148.65 ? 275 MET A N     1 
ATOM 2055 C CA    . MET A 1 275 ? 114.260 99.429  65.799  1.00 149.40 ? 275 MET A CA    1 
ATOM 2056 C C     . MET A 1 275 ? 114.318 98.823  67.195  1.00 150.52 ? 275 MET A C     1 
ATOM 2057 O O     . MET A 1 275 ? 114.695 97.662  67.369  1.00 151.26 ? 275 MET A O     1 
ATOM 2058 C CB    . MET A 1 275 ? 113.375 98.621  64.855  1.00 150.43 ? 275 MET A CB    1 
ATOM 2059 C CG    . MET A 1 275 ? 111.922 98.484  65.281  1.00 150.92 ? 275 MET A CG    1 
ATOM 2060 S SD    . MET A 1 275 ? 111.580 96.963  66.189  1.00 153.50 ? 275 MET A SD    1 
ATOM 2061 C CE    . MET A 1 275 ? 111.675 95.759  64.867  1.00 150.28 ? 275 MET A CE    1 
ATOM 2062 N N     . LYS A 1 276 ? 113.937 99.611  68.195  1.00 144.53 ? 276 LYS A N     1 
ATOM 2063 C CA    . LYS A 1 276 ? 113.973 99.207  69.592  1.00 144.02 ? 276 LYS A CA    1 
ATOM 2064 C C     . LYS A 1 276 ? 112.616 99.437  70.247  1.00 142.56 ? 276 LYS A C     1 
ATOM 2065 O O     . LYS A 1 276 ? 111.839 100.298 69.826  1.00 143.12 ? 276 LYS A O     1 
ATOM 2066 C CB    . LYS A 1 276 ? 115.075 99.969  70.348  1.00 142.64 ? 276 LYS A CB    1 
ATOM 2067 C CG    . LYS A 1 276 ? 115.110 101.486 70.099  1.00 140.67 ? 276 LYS A CG    1 
ATOM 2068 C CD    . LYS A 1 276 ? 114.361 102.291 71.159  1.00 141.22 ? 276 LYS A CD    1 
ATOM 2069 C CE    . LYS A 1 276 ? 114.666 103.772 71.056  1.00 143.22 ? 276 LYS A CE    1 
ATOM 2070 N NZ    . LYS A 1 276 ? 113.792 104.566 71.960  1.00 143.47 ? 276 LYS A NZ    1 
ATOM 2071 N N     . ARG A 1 277 ? 112.346 98.659  71.295  1.00 143.06 ? 277 ARG A N     1 
ATOM 2072 C CA    . ARG A 1 277 ? 111.137 98.832  72.090  1.00 143.42 ? 277 ARG A CA    1 
ATOM 2073 C C     . ARG A 1 277 ? 111.372 98.266  73.482  1.00 142.16 ? 277 ARG A C     1 
ATOM 2074 O O     . ARG A 1 277 ? 112.357 97.567  73.732  1.00 142.01 ? 277 ARG A O     1 
ATOM 2075 C CB    . ARG A 1 277 ? 109.916 98.169  71.437  1.00 145.17 ? 277 ARG A CB    1 
ATOM 2076 C CG    . ARG A 1 277 ? 110.097 96.706  71.074  1.00 145.25 ? 277 ARG A CG    1 
ATOM 2077 C CD    . ARG A 1 277 ? 108.919 96.207  70.245  1.00 143.46 ? 277 ARG A CD    1 
ATOM 2078 N NE    . ARG A 1 277 ? 107.787 95.816  71.077  1.00 143.60 ? 277 ARG A NE    1 
ATOM 2079 C CZ    . ARG A 1 277 ? 106.526 95.791  70.669  1.00 144.39 ? 277 ARG A CZ    1 
ATOM 2080 N NH1   . ARG A 1 277 ? 106.187 96.171  69.450  1.00 142.79 ? 277 ARG A NH1   1 
ATOM 2081 N NH2   . ARG A 1 277 ? 105.581 95.377  71.507  1.00 145.22 ? 277 ARG A NH2   1 
ATOM 2082 N N     . LYS A 1 278 ? 110.451 98.591  74.384  1.00 133.82 ? 278 LYS A N     1 
ATOM 2083 C CA    . LYS A 1 278 ? 110.498 98.157  75.774  1.00 134.26 ? 278 LYS A CA    1 
ATOM 2084 C C     . LYS A 1 278 ? 109.334 97.216  76.050  1.00 134.42 ? 278 LYS A C     1 
ATOM 2085 O O     . LYS A 1 278 ? 108.192 97.509  75.681  1.00 134.59 ? 278 LYS A O     1 
ATOM 2086 C CB    . LYS A 1 278 ? 110.442 99.360  76.715  1.00 135.74 ? 278 LYS A CB    1 
ATOM 2087 C CG    . LYS A 1 278 ? 111.474 100.426 76.401  1.00 134.84 ? 278 LYS A CG    1 
ATOM 2088 C CD    . LYS A 1 278 ? 111.630 101.392 77.554  1.00 133.53 ? 278 LYS A CD    1 
ATOM 2089 C CE    . LYS A 1 278 ? 112.965 102.098 77.500  1.00 132.84 ? 278 LYS A CE    1 
ATOM 2090 N NZ    . LYS A 1 278 ? 113.248 102.777 78.789  1.00 133.00 ? 278 LYS A NZ    1 
ATOM 2091 N N     . TYR A 1 279 ? 109.624 96.093  76.702  1.00 144.54 ? 279 TYR A N     1 
ATOM 2092 C CA    . TYR A 1 279 ? 108.640 95.052  76.950  1.00 144.89 ? 279 TYR A CA    1 
ATOM 2093 C C     . TYR A 1 279 ? 108.275 94.989  78.428  1.00 145.41 ? 279 TYR A C     1 
ATOM 2094 O O     . TYR A 1 279 ? 108.962 95.545  79.290  1.00 146.59 ? 279 TYR A O     1 
ATOM 2095 C CB    . TYR A 1 279 ? 109.155 93.688  76.476  1.00 144.35 ? 279 TYR A CB    1 
ATOM 2096 C CG    . TYR A 1 279 ? 108.797 93.384  75.040  1.00 145.73 ? 279 TYR A CG    1 
ATOM 2097 C CD1   . TYR A 1 279 ? 107.578 92.799  74.716  1.00 145.70 ? 279 TYR A CD1   1 
ATOM 2098 C CD2   . TYR A 1 279 ? 109.674 93.691  74.005  1.00 145.22 ? 279 TYR A CD2   1 
ATOM 2099 C CE1   . TYR A 1 279 ? 107.243 92.525  73.401  1.00 145.65 ? 279 TYR A CE1   1 
ATOM 2100 C CE2   . TYR A 1 279 ? 109.347 93.419  72.687  1.00 145.36 ? 279 TYR A CE2   1 
ATOM 2101 C CZ    . TYR A 1 279 ? 108.132 92.838  72.392  1.00 146.03 ? 279 TYR A CZ    1 
ATOM 2102 O OH    . TYR A 1 279 ? 107.805 92.569  71.081  1.00 146.19 ? 279 TYR A OH    1 
ATOM 2103 N N     . ARG A 1 280 ? 107.170 94.301  78.704  1.00 138.07 ? 280 ARG A N     1 
ATOM 2104 C CA    . ARG A 1 280 ? 106.629 94.147  80.047  1.00 138.42 ? 280 ARG A CA    1 
ATOM 2105 C C     . ARG A 1 280 ? 106.618 92.672  80.426  1.00 138.29 ? 280 ARG A C     1 
ATOM 2106 O O     . ARG A 1 280 ? 106.255 91.817  79.613  1.00 138.23 ? 280 ARG A O     1 
ATOM 2107 C CB    . ARG A 1 280 ? 105.214 94.738  80.142  1.00 138.39 ? 280 ARG A CB    1 
ATOM 2108 C CG    . ARG A 1 280 ? 105.082 95.899  81.121  1.00 137.11 ? 280 ARG A CG    1 
ATOM 2109 C CD    . ARG A 1 280 ? 106.033 97.038  80.795  1.00 137.65 ? 280 ARG A CD    1 
ATOM 2110 N NE    . ARG A 1 280 ? 105.787 97.634  79.488  1.00 140.19 ? 280 ARG A NE    1 
ATOM 2111 C CZ    . ARG A 1 280 ? 106.723 98.216  78.750  1.00 138.82 ? 280 ARG A CZ    1 
ATOM 2112 N NH1   . ARG A 1 280 ? 107.981 98.274  79.152  1.00 137.36 ? 280 ARG A NH1   1 
ATOM 2113 N NH2   . ARG A 1 280 ? 106.386 98.759  77.584  1.00 137.74 ? 280 ARG A NH2   1 
ATOM 2114 N N     . VAL A 1 281 ? 107.018 92.381  81.662  1.00 151.69 ? 281 VAL A N     1 
ATOM 2115 C CA    . VAL A 1 281 ? 107.197 91.015  82.143  1.00 152.70 ? 281 VAL A CA    1 
ATOM 2116 C C     . VAL A 1 281 ? 106.094 90.704  83.146  1.00 153.55 ? 281 VAL A C     1 
ATOM 2117 O O     . VAL A 1 281 ? 105.895 91.446  84.117  1.00 152.41 ? 281 VAL A O     1 
ATOM 2118 C CB    . VAL A 1 281 ? 108.593 90.819  82.757  1.00 153.07 ? 281 VAL A CB    1 
ATOM 2119 C CG1   . VAL A 1 281 ? 108.656 89.569  83.624  1.00 153.40 ? 281 VAL A CG1   1 
ATOM 2120 C CG2   . VAL A 1 281 ? 109.627 90.743  81.658  1.00 152.56 ? 281 VAL A CG2   1 
ATOM 2121 N N     . CYS A 1 282 ? 105.362 89.616  82.892  1.00 163.14 ? 282 CYS A N     1 
ATOM 2122 C CA    . CYS A 1 282 ? 104.322 89.149  83.799  1.00 163.64 ? 282 CYS A CA    1 
ATOM 2123 C C     . CYS A 1 282 ? 104.277 87.638  83.977  1.00 163.00 ? 282 CYS A C     1 
ATOM 2124 O O     . CYS A 1 282 ? 103.465 87.168  84.780  1.00 162.20 ? 282 CYS A O     1 
ATOM 2125 C CB    . CYS A 1 282 ? 102.945 89.629  83.320  1.00 163.27 ? 282 CYS A CB    1 
ATOM 2126 S SG    . CYS A 1 282 ? 102.420 88.928  81.743  1.00 162.98 ? 282 CYS A SG    1 
ATOM 2127 N N     . ASN A 1 283 ? 105.094 86.862  83.266  1.00 163.42 ? 283 ASN A N     1 
ATOM 2128 C CA    . ASN A 1 283 ? 105.056 85.409  83.361  1.00 163.63 ? 283 ASN A CA    1 
ATOM 2129 C C     . ASN A 1 283 ? 106.463 84.849  83.204  1.00 163.44 ? 283 ASN A C     1 
ATOM 2130 O O     . ASN A 1 283 ? 107.343 85.480  82.616  1.00 163.04 ? 283 ASN A O     1 
ATOM 2131 C CB    . ASN A 1 283 ? 104.123 84.801  82.304  1.00 163.48 ? 283 ASN A CB    1 
ATOM 2132 C CG    . ASN A 1 283 ? 103.593 83.439  82.708  1.00 162.24 ? 283 ASN A CG    1 
ATOM 2133 O OD1   . ASN A 1 283 ? 103.826 82.978  83.825  1.00 161.38 ? 283 ASN A OD1   1 
ATOM 2134 N ND2   . ASN A 1 283 ? 102.878 82.788  81.800  1.00 163.00 ? 283 ASN A ND2   1 
ATOM 2135 N N     . VAL A 1 284 ? 106.666 83.649  83.742  1.00 165.51 ? 284 VAL A N     1 
ATOM 2136 C CA    . VAL A 1 284 ? 107.936 82.942  83.602  1.00 165.32 ? 284 VAL A CA    1 
ATOM 2137 C C     . VAL A 1 284 ? 107.739 81.615  82.875  1.00 164.41 ? 284 VAL A C     1 
ATOM 2138 O O     . VAL A 1 284 ? 106.618 81.124  82.738  1.00 163.91 ? 284 VAL A O     1 
ATOM 2139 C CB    . VAL A 1 284 ? 108.606 82.700  84.966  1.00 165.35 ? 284 VAL A CB    1 
ATOM 2140 C CG1   . VAL A 1 284 ? 108.920 84.016  85.651  1.00 163.65 ? 284 VAL A CG1   1 
ATOM 2141 C CG2   . VAL A 1 284 ? 107.721 81.830  85.843  1.00 165.30 ? 284 VAL A CG2   1 
ATOM 2142 N N     . LEU A 1 328 ? 111.845 82.576  80.105  1.00 158.14 ? 328 LEU A N     1 
ATOM 2143 C CA    . LEU A 1 328 ? 111.100 83.733  80.582  1.00 157.89 ? 328 LEU A CA    1 
ATOM 2144 C C     . LEU A 1 328 ? 110.028 84.119  79.569  1.00 157.74 ? 328 LEU A C     1 
ATOM 2145 O O     . LEU A 1 328 ? 110.333 84.544  78.453  1.00 157.95 ? 328 LEU A O     1 
ATOM 2146 C CB    . LEU A 1 328 ? 112.042 84.908  80.845  1.00 159.66 ? 328 LEU A CB    1 
ATOM 2147 C CG    . LEU A 1 328 ? 111.384 86.246  81.176  1.00 159.43 ? 328 LEU A CG    1 
ATOM 2148 C CD1   . LEU A 1 328 ? 110.612 86.151  82.481  1.00 159.99 ? 328 LEU A CD1   1 
ATOM 2149 C CD2   . LEU A 1 328 ? 112.419 87.357  81.242  1.00 158.22 ? 328 LEU A CD2   1 
ATOM 2150 N N     . GLN A 1 329 ? 108.766 83.966  79.970  1.00 162.07 ? 329 GLN A N     1 
ATOM 2151 C CA    . GLN A 1 329 ? 107.626 84.153  79.074  1.00 163.57 ? 329 GLN A CA    1 
ATOM 2152 C C     . GLN A 1 329 ? 107.207 85.619  79.142  1.00 162.96 ? 329 GLN A C     1 
ATOM 2153 O O     . GLN A 1 329 ? 106.333 86.012  79.918  1.00 162.81 ? 329 GLN A O     1 
ATOM 2154 C CB    . GLN A 1 329 ? 106.484 83.217  79.460  1.00 163.07 ? 329 GLN A CB    1 
ATOM 2155 C CG    . GLN A 1 329 ? 106.469 81.861  78.755  1.00 163.29 ? 329 GLN A CG    1 
ATOM 2156 C CD    . GLN A 1 329 ? 107.801 81.127  78.813  1.00 163.85 ? 329 GLN A CD    1 
ATOM 2157 O OE1   . GLN A 1 329 ? 108.381 80.950  79.883  1.00 164.07 ? 329 GLN A OE1   1 
ATOM 2158 N NE2   . GLN A 1 329 ? 108.277 80.675  77.660  1.00 162.99 ? 329 GLN A NE2   1 
ATOM 2159 N N     . VAL A 1 330 ? 107.858 86.440  78.313  1.00 159.27 ? 330 VAL A N     1 
ATOM 2160 C CA    . VAL A 1 330 ? 107.666 87.885  78.372  1.00 158.68 ? 330 VAL A CA    1 
ATOM 2161 C C     . VAL A 1 330 ? 106.301 88.250  77.803  1.00 160.03 ? 330 VAL A C     1 
ATOM 2162 O O     . VAL A 1 330 ? 105.928 87.817  76.704  1.00 161.41 ? 330 VAL A O     1 
ATOM 2163 C CB    . VAL A 1 330 ? 108.797 88.615  77.632  1.00 157.75 ? 330 VAL A CB    1 
ATOM 2164 C CG1   . VAL A 1 330 ? 110.008 88.745  78.527  1.00 158.26 ? 330 VAL A CG1   1 
ATOM 2165 C CG2   . VAL A 1 330 ? 109.179 87.876  76.368  1.00 157.75 ? 330 VAL A CG2   1 
ATOM 2166 N N     . GLY A 1 331 ? 105.542 89.040  78.562  1.00 162.18 ? 331 GLY A N     1 
ATOM 2167 C CA    . GLY A 1 331 ? 104.237 89.468  78.100  1.00 162.44 ? 331 GLY A CA    1 
ATOM 2168 C C     . GLY A 1 331 ? 103.228 88.332  78.110  1.00 162.26 ? 331 GLY A C     1 
ATOM 2169 O O     . GLY A 1 331 ? 103.300 87.397  78.915  1.00 161.57 ? 331 GLY A O     1 
ATOM 2170 N N     . GLN A 1 332 ? 102.283 88.412  77.181  1.00 163.20 ? 332 GLN A N     1 
ATOM 2171 C CA    . GLN A 1 332 ? 101.270 87.381  77.044  1.00 163.09 ? 332 GLN A CA    1 
ATOM 2172 C C     . GLN A 1 332 ? 101.856 86.139  76.375  1.00 162.80 ? 332 GLN A C     1 
ATOM 2173 O O     . GLN A 1 332 ? 102.931 86.171  75.770  1.00 162.34 ? 332 GLN A O     1 
ATOM 2174 C CB    . GLN A 1 332 ? 100.088 87.914  76.236  1.00 163.68 ? 332 GLN A CB    1 
ATOM 2175 C CG    . GLN A 1 332 ? 99.269  88.965  76.970  1.00 163.63 ? 332 GLN A CG    1 
ATOM 2176 C CD    . GLN A 1 332 ? 98.249  89.642  76.077  1.00 163.86 ? 332 GLN A CD    1 
ATOM 2177 O OE1   . GLN A 1 332 ? 98.282  89.499  74.856  1.00 164.33 ? 332 GLN A OE1   1 
ATOM 2178 N NE2   . GLN A 1 332 ? 97.339  90.392  76.686  1.00 163.28 ? 332 GLN A NE2   1 
ATOM 2179 N N     . GLU A 1 333 ? 101.136 85.026  76.503  1.00 164.80 ? 333 GLU A N     1 
ATOM 2180 C CA    . GLU A 1 333 ? 101.522 83.781  75.852  1.00 165.30 ? 333 GLU A CA    1 
ATOM 2181 C C     . GLU A 1 333 ? 101.005 83.679  74.423  1.00 164.56 ? 333 GLU A C     1 
ATOM 2182 O O     . GLU A 1 333 ? 101.404 82.762  73.696  1.00 164.19 ? 333 GLU A O     1 
ATOM 2183 C CB    . GLU A 1 333 ? 101.022 82.582  76.673  1.00 164.86 ? 333 GLU A CB    1 
ATOM 2184 C CG    . GLU A 1 333 ? 101.899 81.330  76.607  1.00 163.91 ? 333 GLU A CG    1 
ATOM 2185 C CD    . GLU A 1 333 ? 102.977 81.296  77.673  1.00 164.33 ? 333 GLU A CD    1 
ATOM 2186 O OE1   . GLU A 1 333 ? 103.080 82.264  78.455  1.00 165.70 ? 333 GLU A OE1   1 
ATOM 2187 O OE2   . GLU A 1 333 ? 103.717 80.292  77.732  1.00 163.29 ? 333 GLU A OE2   1 
ATOM 2188 N N     . GLN A 1 334 ? 100.142 84.598  74.000  1.00 165.72 ? 334 GLN A N     1 
ATOM 2189 C CA    . GLN A 1 334 ? 99.538  84.553  72.676  1.00 165.46 ? 334 GLN A CA    1 
ATOM 2190 C C     . GLN A 1 334 ? 100.327 85.330  71.630  1.00 164.13 ? 334 GLN A C     1 
ATOM 2191 O O     . GLN A 1 334 ? 99.994  85.254  70.443  1.00 163.57 ? 334 GLN A O     1 
ATOM 2192 C CB    . GLN A 1 334 ? 98.104  85.085  72.743  1.00 166.34 ? 334 GLN A CB    1 
ATOM 2193 C CG    . GLN A 1 334 ? 97.115  84.121  73.383  1.00 166.04 ? 334 GLN A CG    1 
ATOM 2194 C CD    . GLN A 1 334 ? 96.971  84.327  74.882  1.00 166.07 ? 334 GLN A CD    1 
ATOM 2195 O OE1   . GLN A 1 334 ? 97.856  84.877  75.538  1.00 166.21 ? 334 GLN A OE1   1 
ATOM 2196 N NE2   . GLN A 1 334 ? 95.848  83.881  75.431  1.00 165.39 ? 334 GLN A NE2   1 
ATOM 2197 N N     . LYS A 1 335 ? 101.364 86.058  72.031  1.00 159.81 ? 335 LYS A N     1 
ATOM 2198 C CA    . LYS A 1 335 ? 102.188 86.797  71.091  1.00 160.27 ? 335 LYS A CA    1 
ATOM 2199 C C     . LYS A 1 335 ? 103.243 85.870  70.489  1.00 161.28 ? 335 LYS A C     1 
ATOM 2200 O O     . LYS A 1 335 ? 103.302 84.676  70.788  1.00 162.71 ? 335 LYS A O     1 
ATOM 2201 C CB    . LYS A 1 335 ? 102.826 88.002  71.781  1.00 159.98 ? 335 LYS A CB    1 
ATOM 2202 C CG    . LYS A 1 335 ? 103.875 87.647  72.822  1.00 160.26 ? 335 LYS A CG    1 
ATOM 2203 C CD    . LYS A 1 335 ? 103.970 88.722  73.893  1.00 161.57 ? 335 LYS A CD    1 
ATOM 2204 C CE    . LYS A 1 335 ? 104.387 90.063  73.316  1.00 161.77 ? 335 LYS A CE    1 
ATOM 2205 N NZ    . LYS A 1 335 ? 104.426 91.111  74.372  1.00 159.97 ? 335 LYS A NZ    1 
ATOM 2206 N N     . HIS A 1 336 ? 104.084 86.420  69.616  1.00 156.36 ? 336 HIS A N     1 
ATOM 2207 C CA    . HIS A 1 336 ? 105.161 85.661  68.997  1.00 156.19 ? 336 HIS A CA    1 
ATOM 2208 C C     . HIS A 1 336 ? 106.533 86.117  69.470  1.00 156.54 ? 336 HIS A C     1 
ATOM 2209 O O     . HIS A 1 336 ? 107.547 85.673  68.922  1.00 157.10 ? 336 HIS A O     1 
ATOM 2210 C CB    . HIS A 1 336 ? 105.073 85.764  67.475  1.00 156.27 ? 336 HIS A CB    1 
ATOM 2211 C CG    . HIS A 1 336 ? 105.150 87.167  66.966  1.00 157.33 ? 336 HIS A CG    1 
ATOM 2212 N ND1   . HIS A 1 336 ? 104.034 87.957  66.797  1.00 157.65 ? 336 HIS A ND1   1 
ATOM 2213 C CD2   . HIS A 1 336 ? 106.208 87.925  66.593  1.00 157.28 ? 336 HIS A CD2   1 
ATOM 2214 C CE1   . HIS A 1 336 ? 104.401 89.141  66.342  1.00 157.39 ? 336 HIS A CE1   1 
ATOM 2215 N NE2   . HIS A 1 336 ? 105.715 89.148  66.208  1.00 156.42 ? 336 HIS A NE2   1 
ATOM 2216 N N     . THR A 1 337 ? 106.591 86.989  70.470  1.00 153.99 ? 337 THR A N     1 
ATOM 2217 C CA    . THR A 1 337 ? 107.851 87.518  70.982  1.00 154.11 ? 337 THR A CA    1 
ATOM 2218 C C     . THR A 1 337 ? 108.106 86.896  72.352  1.00 153.90 ? 337 THR A C     1 
ATOM 2219 O O     . THR A 1 337 ? 107.599 87.366  73.372  1.00 154.07 ? 337 THR A O     1 
ATOM 2220 C CB    . THR A 1 337 ? 107.822 89.038  71.061  1.00 154.84 ? 337 THR A CB    1 
ATOM 2221 O OG1   . THR A 1 337 ? 107.371 89.573  69.811  1.00 154.84 ? 337 THR A OG1   1 
ATOM 2222 C CG2   . THR A 1 337 ? 109.215 89.569  71.356  1.00 154.60 ? 337 THR A CG2   1 
ATOM 2223 N N     . TYR A 1 338 ? 108.894 85.825  72.364  1.00 158.93 ? 338 TYR A N     1 
ATOM 2224 C CA    . TYR A 1 338 ? 109.373 85.205  73.590  1.00 159.67 ? 338 TYR A CA    1 
ATOM 2225 C C     . TYR A 1 338 ? 110.883 85.366  73.667  1.00 160.55 ? 338 TYR A C     1 
ATOM 2226 O O     . TYR A 1 338 ? 111.592 85.104  72.688  1.00 160.27 ? 338 TYR A O     1 
ATOM 2227 C CB    . TYR A 1 338 ? 108.984 83.727  73.662  1.00 159.07 ? 338 TYR A CB    1 
ATOM 2228 C CG    . TYR A 1 338 ? 107.520 83.462  73.397  1.00 158.85 ? 338 TYR A CG    1 
ATOM 2229 C CD1   . TYR A 1 338 ? 106.580 83.587  74.415  1.00 157.57 ? 338 TYR A CD1   1 
ATOM 2230 C CD2   . TYR A 1 338 ? 107.077 83.086  72.132  1.00 159.75 ? 338 TYR A CD2   1 
ATOM 2231 C CE1   . TYR A 1 338 ? 105.238 83.345  74.182  1.00 158.18 ? 338 TYR A CE1   1 
ATOM 2232 C CE2   . TYR A 1 338 ? 105.738 82.842  71.889  1.00 159.32 ? 338 TYR A CE2   1 
ATOM 2233 C CZ    . TYR A 1 338 ? 104.826 82.972  72.918  1.00 159.00 ? 338 TYR A CZ    1 
ATOM 2234 O OH    . TYR A 1 338 ? 103.496 82.730  72.673  1.00 158.50 ? 338 TYR A OH    1 
ATOM 2235 N N     . LEU A 1 339 ? 111.366 85.810  74.824  1.00 161.39 ? 339 LEU A N     1 
ATOM 2236 C CA    . LEU A 1 339 ? 112.770 86.146  75.016  1.00 160.26 ? 339 LEU A CA    1 
ATOM 2237 C C     . LEU A 1 339 ? 113.417 85.174  75.992  1.00 160.14 ? 339 LEU A C     1 
ATOM 2238 O O     . LEU A 1 339 ? 113.024 85.137  77.169  1.00 160.37 ? 339 LEU A O     1 
ATOM 2239 C CB    . LEU A 1 339 ? 112.902 87.579  75.534  1.00 158.63 ? 339 LEU A CB    1 
ATOM 2240 C CG    . LEU A 1 339 ? 112.447 88.727  74.630  1.00 158.81 ? 339 LEU A CG    1 
ATOM 2241 C CD1   . LEU A 1 339 ? 112.964 90.047  75.175  1.00 158.85 ? 339 LEU A CD1   1 
ATOM 2242 C CD2   . LEU A 1 339 ? 112.893 88.525  73.189  1.00 158.07 ? 339 LEU A CD2   1 
ATOM 2243 N N     . PRO A 1 340 ? 114.406 84.378  75.569  1.00 159.52 ? 340 PRO A N     1 
ATOM 2244 C CA    . PRO A 1 340 ? 115.180 83.587  76.538  1.00 158.64 ? 340 PRO A CA    1 
ATOM 2245 C C     . PRO A 1 340 ? 116.164 84.433  77.337  1.00 158.98 ? 340 PRO A C     1 
ATOM 2246 O O     . PRO A 1 340 ? 116.197 85.662  77.213  1.00 158.20 ? 340 PRO A O     1 
ATOM 2247 C CB    . PRO A 1 340 ? 115.912 82.561  75.660  1.00 158.61 ? 340 PRO A CB    1 
ATOM 2248 C CG    . PRO A 1 340 ? 115.205 82.584  74.343  1.00 159.00 ? 340 PRO A CG    1 
ATOM 2249 C CD    . PRO A 1 340 ? 114.685 83.974  74.183  1.00 159.38 ? 340 PRO A CD    1 
ATOM 2250 N N     . LEU A 1 341 ? 116.985 83.772  78.156  1.00 155.13 ? 341 LEU A N     1 
ATOM 2251 C CA    . LEU A 1 341 ? 117.888 84.488  79.049  1.00 154.75 ? 341 LEU A CA    1 
ATOM 2252 C C     . LEU A 1 341 ? 119.071 85.118  78.321  1.00 153.69 ? 341 LEU A C     1 
ATOM 2253 O O     . LEU A 1 341 ? 119.714 86.012  78.878  1.00 152.79 ? 341 LEU A O     1 
ATOM 2254 C CB    . LEU A 1 341 ? 118.392 83.543  80.141  1.00 155.09 ? 341 LEU A CB    1 
ATOM 2255 C CG    . LEU A 1 341 ? 117.349 82.597  80.742  1.00 154.19 ? 341 LEU A CG    1 
ATOM 2256 C CD1   . LEU A 1 341 ? 118.004 81.572  81.653  1.00 153.90 ? 341 LEU A CD1   1 
ATOM 2257 C CD2   . LEU A 1 341 ? 116.294 83.385  81.501  1.00 153.74 ? 341 LEU A CD2   1 
ATOM 2258 N N     . GLU A 1 342 ? 119.366 84.694  77.097  1.00 147.93 ? 342 GLU A N     1 
ATOM 2259 C CA    . GLU A 1 342 ? 120.532 85.195  76.384  1.00 147.46 ? 342 GLU A CA    1 
ATOM 2260 C C     . GLU A 1 342 ? 120.265 86.475  75.599  1.00 147.67 ? 342 GLU A C     1 
ATOM 2261 O O     . GLU A 1 342 ? 121.214 87.062  75.071  1.00 147.60 ? 342 GLU A O     1 
ATOM 2262 C CB    . GLU A 1 342 ? 121.078 84.117  75.442  1.00 147.98 ? 342 GLU A CB    1 
ATOM 2263 C CG    . GLU A 1 342 ? 120.009 83.301  74.735  1.00 147.86 ? 342 GLU A CG    1 
ATOM 2264 C CD    . GLU A 1 342 ? 120.588 82.129  73.966  1.00 148.05 ? 342 GLU A CD    1 
ATOM 2265 O OE1   . GLU A 1 342 ? 121.731 82.244  73.476  1.00 148.06 ? 342 GLU A OE1   1 
ATOM 2266 O OE2   . GLU A 1 342 ? 119.902 81.092  73.854  1.00 148.13 ? 342 GLU A OE2   1 
ATOM 2267 N N     . VAL A 1 343 ? 119.011 86.925  75.503  1.00 148.85 ? 343 VAL A N     1 
ATOM 2268 C CA    . VAL A 1 343 ? 118.674 88.123  74.739  1.00 149.54 ? 343 VAL A CA    1 
ATOM 2269 C C     . VAL A 1 343 ? 117.999 89.196  75.579  1.00 149.32 ? 343 VAL A C     1 
ATOM 2270 O O     . VAL A 1 343 ? 117.680 90.263  75.052  1.00 148.99 ? 343 VAL A O     1 
ATOM 2271 C CB    . VAL A 1 343 ? 117.796 87.791  73.513  1.00 151.20 ? 343 VAL A CB    1 
ATOM 2272 C CG1   . VAL A 1 343 ? 118.495 86.810  72.574  1.00 151.23 ? 343 VAL A CG1   1 
ATOM 2273 C CG2   . VAL A 1 343 ? 116.444 87.262  73.956  1.00 149.95 ? 343 VAL A CG2   1 
ATOM 2274 N N     . CYS A 1 344 ? 117.753 88.951  76.864  1.00 152.79 ? 344 CYS A N     1 
ATOM 2275 C CA    . CYS A 1 344 ? 117.066 89.935  77.691  1.00 153.12 ? 344 CYS A CA    1 
ATOM 2276 C C     . CYS A 1 344 ? 118.026 91.041  78.114  1.00 151.64 ? 344 CYS A C     1 
ATOM 2277 O O     . CYS A 1 344 ? 119.167 90.772  78.497  1.00 152.03 ? 344 CYS A O     1 
ATOM 2278 C CB    . CYS A 1 344 ? 116.463 89.262  78.922  1.00 152.52 ? 344 CYS A CB    1 
ATOM 2279 S SG    . CYS A 1 344 ? 114.917 88.381  78.612  1.00 152.94 ? 344 CYS A SG    1 
ATOM 2280 N N     . ASN A 1 345 ? 117.565 92.290  78.033  1.00 151.71 ? 345 ASN A N     1 
ATOM 2281 C CA    . ASN A 1 345 ? 118.344 93.455  78.451  1.00 153.08 ? 345 ASN A CA    1 
ATOM 2282 C C     . ASN A 1 345 ? 117.482 94.309  79.371  1.00 153.28 ? 345 ASN A C     1 
ATOM 2283 O O     . ASN A 1 345 ? 116.423 94.792  78.960  1.00 153.22 ? 345 ASN A O     1 
ATOM 2284 C CB    . ASN A 1 345 ? 118.824 94.270  77.248  1.00 153.03 ? 345 ASN A CB    1 
ATOM 2285 C CG    . ASN A 1 345 ? 119.354 93.401  76.122  1.00 153.20 ? 345 ASN A CG    1 
ATOM 2286 O OD1   . ASN A 1 345 ? 118.680 93.189  75.114  1.00 152.79 ? 345 ASN A OD1   1 
ATOM 2287 N ND2   . ASN A 1 345 ? 120.569 92.896  76.289  1.00 153.56 ? 345 ASN A ND2   1 
ATOM 2288 N N     . ILE A 1 346 ? 117.946 94.517  80.600  1.00 138.46 ? 346 ILE A N     1 
ATOM 2289 C CA    . ILE A 1 346 ? 117.186 95.247  81.611  1.00 135.76 ? 346 ILE A CA    1 
ATOM 2290 C C     . ILE A 1 346 ? 117.559 96.723  81.541  1.00 134.59 ? 346 ILE A C     1 
ATOM 2291 O O     . ILE A 1 346 ? 118.734 97.083  81.662  1.00 134.16 ? 346 ILE A O     1 
ATOM 2292 C CB    . ILE A 1 346 ? 117.442 94.677  83.016  1.00 134.77 ? 346 ILE A CB    1 
ATOM 2293 C CG1   . ILE A 1 346 ? 116.931 93.232  83.096  1.00 134.32 ? 346 ILE A CG1   1 
ATOM 2294 C CG2   . ILE A 1 346 ? 116.817 95.582  84.086  1.00 135.95 ? 346 ILE A CG2   1 
ATOM 2295 C CD1   . ILE A 1 346 ? 116.735 92.693  84.501  1.00 134.82 ? 346 ILE A CD1   1 
ATOM 2296 N N     . VAL A 1 347 ? 116.554 97.576  81.346  1.00 122.50 ? 347 VAL A N     1 
ATOM 2297 C CA    . VAL A 1 347 ? 116.744 99.021  81.292  1.00 121.45 ? 347 VAL A CA    1 
ATOM 2298 C C     . VAL A 1 347 ? 116.635 99.535  82.728  1.00 121.05 ? 347 VAL A C     1 
ATOM 2299 O O     . VAL A 1 347 ? 115.958 98.918  83.560  1.00 121.16 ? 347 VAL A O     1 
ATOM 2300 C CB    . VAL A 1 347 ? 115.712 99.655  80.330  1.00 121.66 ? 347 VAL A CB    1 
ATOM 2301 C CG1   . VAL A 1 347 ? 114.280 99.277  80.717  1.00 121.47 ? 347 VAL A CG1   1 
ATOM 2302 C CG2   . VAL A 1 347 ? 115.905 101.166 80.131  1.00 122.09 ? 347 VAL A CG2   1 
ATOM 2303 N N     . ALA A 1 348 ? 117.331 100.633 83.041  1.00 117.00 ? 348 ALA A N     1 
ATOM 2304 C CA    . ALA A 1 348 ? 117.384 101.193 84.384  1.00 116.71 ? 348 ALA A CA    1 
ATOM 2305 C C     . ALA A 1 348 ? 116.018 101.723 84.821  1.00 116.42 ? 348 ALA A C     1 
ATOM 2306 O O     . ALA A 1 348 ? 115.141 102.029 84.009  1.00 116.81 ? 348 ALA A O     1 
ATOM 2307 C CB    . ALA A 1 348 ? 118.418 102.314 84.457  1.00 116.44 ? 348 ALA A CB    1 
ATOM 2308 N N     . GLY A 1 349 ? 115.856 101.840 86.135  1.00 117.78 ? 349 GLY A N     1 
ATOM 2309 C CA    . GLY A 1 349 ? 114.588 102.189 86.736  1.00 117.38 ? 349 GLY A CA    1 
ATOM 2310 C C     . GLY A 1 349 ? 113.945 101.099 87.565  1.00 118.30 ? 349 GLY A C     1 
ATOM 2311 O O     . GLY A 1 349 ? 112.787 101.256 87.965  1.00 118.30 ? 349 GLY A O     1 
ATOM 2312 N N     . GLN A 1 350 ? 114.657 100.006 87.843  1.00 127.11 ? 350 GLN A N     1 
ATOM 2313 C CA    . GLN A 1 350 ? 114.093 98.850  88.531  1.00 127.77 ? 350 GLN A CA    1 
ATOM 2314 C C     . GLN A 1 350 ? 114.741 98.696  89.904  1.00 127.79 ? 350 GLN A C     1 
ATOM 2315 O O     . GLN A 1 350 ? 115.959 98.511  89.999  1.00 127.39 ? 350 GLN A O     1 
ATOM 2316 C CB    . GLN A 1 350 ? 114.290 97.574  87.710  1.00 128.25 ? 350 GLN A CB    1 
ATOM 2317 C CG    . GLN A 1 350 ? 114.177 97.737  86.193  1.00 128.29 ? 350 GLN A CG    1 
ATOM 2318 C CD    . GLN A 1 350 ? 112.867 98.365  85.749  1.00 128.61 ? 350 GLN A CD    1 
ATOM 2319 O OE1   . GLN A 1 350 ? 111.793 97.999  86.229  1.00 128.87 ? 350 GLN A OE1   1 
ATOM 2320 N NE2   . GLN A 1 350 ? 112.950 99.314  84.823  1.00 127.65 ? 350 GLN A NE2   1 
ATOM 2321 N N     . ARG A 1 351 ? 113.922 98.756  90.951  1.00 130.68 ? 351 ARG A N     1 
ATOM 2322 C CA    . ARG A 1 351 ? 114.318 98.538  92.345  1.00 131.38 ? 351 ARG A CA    1 
ATOM 2323 C C     . ARG A 1 351 ? 113.036 98.191  93.111  1.00 129.89 ? 351 ARG A C     1 
ATOM 2324 O O     . ARG A 1 351 ? 111.987 97.967  92.493  1.00 130.68 ? 351 ARG A O     1 
ATOM 2325 C CB    . ARG A 1 351 ? 115.101 99.747  92.893  1.00 130.69 ? 351 ARG A CB    1 
ATOM 2326 C CG    . ARG A 1 351 ? 114.323 100.913 93.519  1.00 129.87 ? 351 ARG A CG    1 
ATOM 2327 C CD    . ARG A 1 351 ? 113.447 101.672 92.567  1.00 129.58 ? 351 ARG A CD    1 
ATOM 2328 N NE    . ARG A 1 351 ? 112.452 102.405 93.335  1.00 128.21 ? 351 ARG A NE    1 
ATOM 2329 C CZ    . ARG A 1 351 ? 111.165 102.092 93.383  1.00 129.06 ? 351 ARG A CZ    1 
ATOM 2330 N NH1   . ARG A 1 351 ? 110.664 101.113 92.650  1.00 131.67 ? 351 ARG A NH1   1 
ATOM 2331 N NH2   . ARG A 1 351 ? 110.358 102.792 94.175  1.00 129.21 ? 351 ARG A NH2   1 
ATOM 2332 N N     . CYS A 1 352 ? 113.140 98.055  94.446  1.00 131.95 ? 352 CYS A N     1 
ATOM 2333 C CA    . CYS A 1 352 ? 112.100 97.965  95.475  1.00 133.97 ? 352 CYS A CA    1 
ATOM 2334 C C     . CYS A 1 352 ? 111.487 96.554  95.523  1.00 136.06 ? 352 CYS A C     1 
ATOM 2335 O O     . CYS A 1 352 ? 110.785 96.232  96.483  1.00 135.20 ? 352 CYS A O     1 
ATOM 2336 C CB    . CYS A 1 352 ? 111.003 99.050  95.320  1.00 134.25 ? 352 CYS A CB    1 
ATOM 2337 S SG    . CYS A 1 352 ? 109.471 99.071  96.317  1.00 137.59 ? 352 CYS A SG    1 
ATOM 2338 N N     . ILE A 1 353 ? 111.836 95.666  94.597  1.00 144.22 ? 353 ILE A N     1 
ATOM 2339 C CA    . ILE A 1 353 ? 111.358 94.288  94.611  1.00 145.12 ? 353 ILE A CA    1 
ATOM 2340 C C     . ILE A 1 353 ? 112.544 93.432  95.050  1.00 145.55 ? 353 ILE A C     1 
ATOM 2341 O O     . ILE A 1 353 ? 112.715 92.292  94.602  1.00 146.24 ? 353 ILE A O     1 
ATOM 2342 C CB    . ILE A 1 353 ? 110.795 93.863  93.238  1.00 146.08 ? 353 ILE A CB    1 
ATOM 2343 C CG1   . ILE A 1 353 ? 110.182 95.062  92.495  1.00 145.19 ? 353 ILE A CG1   1 
ATOM 2344 C CG2   . ILE A 1 353 ? 109.717 92.781  93.397  1.00 143.74 ? 353 ILE A CG2   1 
ATOM 2345 C CD1   . ILE A 1 353 ? 108.854 95.591  93.065  1.00 143.70 ? 353 ILE A CD1   1 
ATOM 2346 N N     . LYS A 1 354 ? 113.389 94.008  95.907  1.00 143.04 ? 354 LYS A N     1 
ATOM 2347 C CA    . LYS A 1 354 ? 114.630 93.388  96.348  1.00 142.90 ? 354 LYS A CA    1 
ATOM 2348 C C     . LYS A 1 354 ? 114.366 92.161  97.218  1.00 144.21 ? 354 LYS A C     1 
ATOM 2349 O O     . LYS A 1 354 ? 113.326 92.035  97.870  1.00 144.32 ? 354 LYS A O     1 
ATOM 2350 C CB    . LYS A 1 354 ? 115.466 94.385  97.149  1.00 141.58 ? 354 LYS A CB    1 
ATOM 2351 C CG    . LYS A 1 354 ? 116.100 95.487  96.332  1.00 141.41 ? 354 LYS A CG    1 
ATOM 2352 C CD    . LYS A 1 354 ? 117.188 94.950  95.441  1.00 142.47 ? 354 LYS A CD    1 
ATOM 2353 C CE    . LYS A 1 354 ? 117.932 96.081  94.777  1.00 142.09 ? 354 LYS A CE    1 
ATOM 2354 N NZ    . LYS A 1 354 ? 119.337 95.690  94.499  1.00 141.80 ? 354 LYS A NZ    1 
ATOM 2355 N N     . LYS A 1 355 ? 115.343 91.249  97.223  1.00 156.57 ? 355 LYS A N     1 
ATOM 2356 C CA    . LYS A 1 355 ? 115.311 90.093  98.118  1.00 156.64 ? 355 LYS A CA    1 
ATOM 2357 C C     . LYS A 1 355 ? 116.763 89.705  98.409  1.00 156.18 ? 355 LYS A C     1 
ATOM 2358 O O     . LYS A 1 355 ? 117.416 89.072  97.574  1.00 156.01 ? 355 LYS A O     1 
ATOM 2359 C CB    . LYS A 1 355 ? 114.524 88.939  97.511  1.00 155.14 ? 355 LYS A CB    1 
ATOM 2360 C CG    . LYS A 1 355 ? 114.550 87.648  98.326  1.00 154.56 ? 355 LYS A CG    1 
ATOM 2361 C CD    . LYS A 1 355 ? 114.021 87.854  99.735  1.00 155.45 ? 355 LYS A CD    1 
ATOM 2362 C CE    . LYS A 1 355 ? 114.866 87.091  100.744 1.00 155.97 ? 355 LYS A CE    1 
ATOM 2363 N NZ    . LYS A 1 355 ? 114.897 87.756  102.075 1.00 156.05 ? 355 LYS A NZ    1 
ATOM 2364 N N     . LEU A 1 356 ? 117.251 90.107  99.581  1.00 152.10 ? 356 LEU A N     1 
ATOM 2365 C CA    . LEU A 1 356 ? 118.586 89.752  100.046 1.00 151.36 ? 356 LEU A CA    1 
ATOM 2366 C C     . LEU A 1 356 ? 118.601 89.874  101.564 1.00 151.03 ? 356 LEU A C     1 
ATOM 2367 O O     . LEU A 1 356 ? 117.688 90.441  102.171 1.00 150.46 ? 356 LEU A O     1 
ATOM 2368 C CB    . LEU A 1 356 ? 119.669 90.639  99.410  1.00 151.52 ? 356 LEU A CB    1 
ATOM 2369 C CG    . LEU A 1 356 ? 121.054 90.005  99.205  1.00 150.88 ? 356 LEU A CG    1 
ATOM 2370 C CD1   . LEU A 1 356 ? 120.942 88.647  98.517  1.00 150.83 ? 356 LEU A CD1   1 
ATOM 2371 C CD2   . LEU A 1 356 ? 122.010 90.914  98.458  1.00 150.62 ? 356 LEU A CD2   1 
ATOM 2372 N N     . THR A 1 357 ? 119.647 89.319  102.171 1.00 146.69 ? 357 THR A N     1 
ATOM 2373 C CA    . THR A 1 357 ? 119.861 89.436  103.604 1.00 147.38 ? 357 THR A CA    1 
ATOM 2374 C C     . THR A 1 357 ? 120.215 90.875  103.982 1.00 148.05 ? 357 THR A C     1 
ATOM 2375 O O     . THR A 1 357 ? 120.672 91.673  103.158 1.00 146.78 ? 357 THR A O     1 
ATOM 2376 C CB    . THR A 1 357 ? 120.964 88.480  104.062 1.00 148.26 ? 357 THR A CB    1 
ATOM 2377 O OG1   . THR A 1 357 ? 122.234 89.127  103.942 1.00 148.56 ? 357 THR A OG1   1 
ATOM 2378 C CG2   . THR A 1 357 ? 120.966 87.210  103.219 1.00 146.89 ? 357 THR A CG2   1 
ATOM 2379 N N     . ASP A 1 358 ? 120.005 91.196  105.260 1.00 139.31 ? 358 ASP A N     1 
ATOM 2380 C CA    . ASP A 1 358 ? 119.995 92.588  105.698 1.00 138.11 ? 358 ASP A CA    1 
ATOM 2381 C C     . ASP A 1 358 ? 121.378 93.141  106.026 1.00 136.64 ? 358 ASP A C     1 
ATOM 2382 O O     . ASP A 1 358 ? 121.477 94.312  106.408 1.00 134.94 ? 358 ASP A O     1 
ATOM 2383 C CB    . ASP A 1 358 ? 119.088 92.737  106.916 1.00 135.86 ? 358 ASP A CB    1 
ATOM 2384 C CG    . ASP A 1 358 ? 119.519 91.855  108.065 1.00 136.66 ? 358 ASP A CG    1 
ATOM 2385 O OD1   . ASP A 1 358 ? 120.011 90.738  107.802 1.00 138.75 ? 358 ASP A OD1   1 
ATOM 2386 O OD2   . ASP A 1 358 ? 119.379 92.277  109.229 1.00 135.38 ? 358 ASP A OD2   1 
ATOM 2387 N N     . ASN A 1 359 ? 122.443 92.340  105.911 1.00 136.36 ? 359 ASN A N     1 
ATOM 2388 C CA    . ASN A 1 359 ? 123.782 92.872  106.163 1.00 136.17 ? 359 ASN A CA    1 
ATOM 2389 C C     . ASN A 1 359 ? 124.225 93.802  105.038 1.00 136.18 ? 359 ASN A C     1 
ATOM 2390 O O     . ASN A 1 359 ? 124.944 94.784  105.275 1.00 134.74 ? 359 ASN A O     1 
ATOM 2391 C CB    . ASN A 1 359 ? 124.781 91.730  106.351 1.00 135.81 ? 359 ASN A CB    1 
ATOM 2392 C CG    . ASN A 1 359 ? 124.591 90.618  105.345 1.00 133.31 ? 359 ASN A CG    1 
ATOM 2393 O OD1   . ASN A 1 359 ? 123.898 89.637  105.613 1.00 131.31 ? 359 ASN A OD1   1 
ATOM 2394 N ND2   . ASN A 1 359 ? 125.208 90.761  104.178 1.00 132.60 ? 359 ASN A ND2   1 
ATOM 2395 N N     . GLN A 1 360 ? 123.792 93.511  103.807 1.00 133.34 ? 360 GLN A N     1 
ATOM 2396 C CA    . GLN A 1 360 ? 124.004 94.435  102.698 1.00 132.56 ? 360 GLN A CA    1 
ATOM 2397 C C     . GLN A 1 360 ? 123.220 95.725  102.906 1.00 131.95 ? 360 GLN A C     1 
ATOM 2398 O O     . GLN A 1 360 ? 123.702 96.812  102.569 1.00 131.96 ? 360 GLN A O     1 
ATOM 2399 C CB    . GLN A 1 360 ? 123.612 93.770  101.379 1.00 132.38 ? 360 GLN A CB    1 
ATOM 2400 C CG    . GLN A 1 360 ? 124.361 92.478  101.079 1.00 132.66 ? 360 GLN A CG    1 
ATOM 2401 C CD    . GLN A 1 360 ? 125.870 92.630  101.159 1.00 132.36 ? 360 GLN A CD    1 
ATOM 2402 O OE1   . GLN A 1 360 ? 126.546 91.863  101.843 1.00 132.99 ? 360 GLN A OE1   1 
ATOM 2403 N NE2   . GLN A 1 360 ? 126.407 93.609  100.437 1.00 131.52 ? 360 GLN A NE2   1 
ATOM 2404 N N     . THR A 1 361 ? 122.022 95.618  103.492 1.00 120.44 ? 361 THR A N     1 
ATOM 2405 C CA    . THR A 1 361 ? 121.241 96.798  103.856 1.00 120.74 ? 361 THR A CA    1 
ATOM 2406 C C     . THR A 1 361 ? 121.952 97.615  104.935 1.00 120.51 ? 361 THR A C     1 
ATOM 2407 O O     . THR A 1 361 ? 121.994 98.847  104.858 1.00 119.88 ? 361 THR A O     1 
ATOM 2408 C CB    . THR A 1 361 ? 119.839 96.358  104.302 1.00 120.79 ? 361 THR A CB    1 
ATOM 2409 O OG1   . THR A 1 361 ? 119.075 95.983  103.149 1.00 119.96 ? 361 THR A OG1   1 
ATOM 2410 C CG2   . THR A 1 361 ? 119.079 97.460  105.049 1.00 120.76 ? 361 THR A CG2   1 
ATOM 2411 N N     . SER A 1 362 ? 122.579 96.939  105.904 1.00 113.85 ? 362 SER A N     1 
ATOM 2412 C CA    . SER A 1 362 ? 123.284 97.635  106.982 1.00 114.01 ? 362 SER A CA    1 
ATOM 2413 C C     . SER A 1 362 ? 124.540 98.348  106.479 1.00 114.71 ? 362 SER A C     1 
ATOM 2414 O O     . SER A 1 362 ? 124.811 99.495  106.860 1.00 113.99 ? 362 SER A O     1 
ATOM 2415 C CB    . SER A 1 362 ? 123.635 96.649  108.093 1.00 114.58 ? 362 SER A CB    1 
ATOM 2416 O OG    . SER A 1 362 ? 124.525 97.243  109.019 1.00 113.26 ? 362 SER A OG    1 
ATOM 2417 N N     . THR A 1 363 ? 125.318 97.697  105.608 1.00 109.93 ? 363 THR A N     1 
ATOM 2418 C CA    . THR A 1 363 ? 126.480 98.397  105.062 1.00 109.66 ? 363 THR A CA    1 
ATOM 2419 C C     . THR A 1 363 ? 126.077 99.444  104.022 1.00 109.66 ? 363 THR A C     1 
ATOM 2420 O O     . THR A 1 363 ? 126.825 100.405 103.800 1.00 112.95 ? 363 THR A O     1 
ATOM 2421 C CB    . THR A 1 363 ? 127.502 97.399  104.491 1.00 109.81 ? 363 THR A CB    1 
ATOM 2422 O OG1   . THR A 1 363 ? 128.713 98.091  104.157 1.00 112.91 ? 363 THR A OG1   1 
ATOM 2423 C CG2   . THR A 1 363 ? 126.979 96.686  103.255 1.00 110.49 ? 363 THR A CG2   1 
ATOM 2424 N N     . MET A 1 364 ? 124.888 99.313  103.426 1.00 98.82  ? 364 MET A N     1 
ATOM 2425 C CA    . MET A 1 364 ? 124.357 100.354 102.556 1.00 101.03 ? 364 MET A CA    1 
ATOM 2426 C C     . MET A 1 364 ? 123.926 101.562 103.387 1.00 102.44 ? 364 MET A C     1 
ATOM 2427 O O     . MET A 1 364 ? 124.086 102.711 102.960 1.00 99.53  ? 364 MET A O     1 
ATOM 2428 C CB    . MET A 1 364 ? 123.212 99.733  101.737 1.00 100.98 ? 364 MET A CB    1 
ATOM 2429 C CG    . MET A 1 364 ? 122.601 100.464 100.524 1.00 102.54 ? 364 MET A CG    1 
ATOM 2430 S SD    . MET A 1 364 ? 121.939 102.123 100.652 1.00 101.09 ? 364 MET A SD    1 
ATOM 2431 C CE    . MET A 1 364 ? 120.617 101.851 101.821 1.00 98.58  ? 364 MET A CE    1 
ATOM 2432 N N     . ILE A 1 365 ? 123.407 101.309 104.593 1.00 98.60  ? 365 ILE A N     1 
ATOM 2433 C CA    . ILE A 1 365 ? 123.125 102.355 105.577 1.00 97.08  ? 365 ILE A CA    1 
ATOM 2434 C C     . ILE A 1 365 ? 124.411 103.050 106.015 1.00 94.02  ? 365 ILE A C     1 
ATOM 2435 O O     . ILE A 1 365 ? 124.439 104.279 106.189 1.00 93.60  ? 365 ILE A O     1 
ATOM 2436 C CB    . ILE A 1 365 ? 122.341 101.738 106.764 1.00 96.48  ? 365 ILE A CB    1 
ATOM 2437 C CG1   . ILE A 1 365 ? 120.871 101.489 106.384 1.00 94.94  ? 365 ILE A CG1   1 
ATOM 2438 C CG2   . ILE A 1 365 ? 122.472 102.545 108.067 1.00 94.76  ? 365 ILE A CG2   1 
ATOM 2439 C CD1   . ILE A 1 365 ? 120.208 102.621 105.625 1.00 94.20  ? 365 ILE A CD1   1 
ATOM 2440 N N     . ARG A 1 366 ? 125.494 102.277 106.171 1.00 88.57  ? 366 ARG A N     1 
ATOM 2441 C CA    . ARG A 1 366 ? 126.812 102.849 106.455 1.00 90.99  ? 366 ARG A CA    1 
ATOM 2442 C C     . ARG A 1 366 ? 127.272 103.719 105.279 1.00 90.02  ? 366 ARG A C     1 
ATOM 2443 O O     . ARG A 1 366 ? 127.877 104.777 105.483 1.00 89.10  ? 366 ARG A O     1 
ATOM 2444 C CB    . ARG A 1 366 ? 127.797 101.698 106.746 1.00 89.09  ? 366 ARG A CB    1 
ATOM 2445 C CG    . ARG A 1 366 ? 129.341 101.848 106.538 1.00 89.96  ? 366 ARG A CG    1 
ATOM 2446 C CD    . ARG A 1 366 ? 130.001 103.066 107.233 1.00 89.44  ? 366 ARG A CD    1 
ATOM 2447 N NE    . ARG A 1 366 ? 131.275 103.436 106.635 1.00 86.76  ? 366 ARG A NE    1 
ATOM 2448 C CZ    . ARG A 1 366 ? 131.398 104.309 105.647 1.00 86.62  ? 366 ARG A CZ    1 
ATOM 2449 N NH1   . ARG A 1 366 ? 130.341 104.898 105.114 1.00 85.14  ? 366 ARG A NH1   1 
ATOM 2450 N NH2   . ARG A 1 366 ? 132.609 104.596 105.182 1.00 89.20  ? 366 ARG A NH2   1 
ATOM 2451 N N     . ALA A 1 367 ? 126.916 103.332 104.045 1.00 89.41  ? 367 ALA A N     1 
ATOM 2452 C CA    . ALA A 1 367 ? 127.297 104.119 102.870 1.00 91.02  ? 367 ALA A CA    1 
ATOM 2453 C C     . ALA A 1 367 ? 126.541 105.447 102.774 1.00 93.63  ? 367 ALA A C     1 
ATOM 2454 O O     . ALA A 1 367 ? 126.943 106.329 102.007 1.00 93.01  ? 367 ALA A O     1 
ATOM 2455 C CB    . ALA A 1 367 ? 127.091 103.296 101.599 1.00 90.58  ? 367 ALA A CB    1 
ATOM 2456 N N     . THR A 1 368 ? 125.459 105.614 103.533 1.00 82.44  ? 368 THR A N     1 
ATOM 2457 C CA    . THR A 1 368 ? 124.787 106.903 103.656 1.00 81.60  ? 368 THR A CA    1 
ATOM 2458 C C     . THR A 1 368 ? 125.234 107.668 104.901 1.00 74.88  ? 368 THR A C     1 
ATOM 2459 O O     . THR A 1 368 ? 125.199 108.906 104.904 1.00 72.19  ? 368 THR A O     1 
ATOM 2460 C CB    . THR A 1 368 ? 123.265 106.692 103.685 1.00 78.29  ? 368 THR A CB    1 
ATOM 2461 O OG1   . THR A 1 368 ? 122.903 105.752 102.668 1.00 75.76  ? 368 THR A OG1   1 
ATOM 2462 C CG2   . THR A 1 368 ? 122.507 107.994 103.410 1.00 76.45  ? 368 THR A CG2   1 
ATOM 2463 N N     . ALA A 1 369 ? 125.716 106.962 105.927 1.00 67.33  ? 369 ALA A N     1 
ATOM 2464 C CA    . ALA A 1 369 ? 126.020 107.534 107.240 1.00 67.73  ? 369 ALA A CA    1 
ATOM 2465 C C     . ALA A 1 369 ? 127.262 108.404 107.127 1.00 71.38  ? 369 ALA A C     1 
ATOM 2466 O O     . ALA A 1 369 ? 128.397 107.927 107.158 1.00 70.48  ? 369 ALA A O     1 
ATOM 2467 C CB    . ALA A 1 369 ? 126.205 106.432 108.275 1.00 69.19  ? 369 ALA A CB    1 
ATOM 2468 N N     . ARG A 1 370 ? 127.032 109.706 106.976 1.00 71.69  ? 370 ARG A N     1 
ATOM 2469 C CA    . ARG A 1 370 ? 128.082 110.677 106.719 1.00 66.00  ? 370 ARG A CA    1 
ATOM 2470 C C     . ARG A 1 370 ? 127.975 111.795 107.744 1.00 61.05  ? 370 ARG A C     1 
ATOM 2471 O O     . ARG A 1 370 ? 126.868 112.179 108.131 1.00 62.50  ? 370 ARG A O     1 
ATOM 2472 C CB    . ARG A 1 370 ? 127.958 111.221 105.295 1.00 62.92  ? 370 ARG A CB    1 
ATOM 2473 C CG    . ARG A 1 370 ? 128.265 110.182 104.211 1.00 64.50  ? 370 ARG A CG    1 
ATOM 2474 C CD    . ARG A 1 370 ? 129.746 109.870 104.092 1.00 62.46  ? 370 ARG A CD    1 
ATOM 2475 N NE    . ARG A 1 370 ? 130.169 108.728 104.892 1.00 66.75  ? 370 ARG A NE    1 
ATOM 2476 C CZ    . ARG A 1 370 ? 131.287 108.696 105.604 1.00 62.25  ? 370 ARG A CZ    1 
ATOM 2477 N NH1   . ARG A 1 370 ? 132.103 109.737 105.652 1.00 58.98  ? 370 ARG A NH1   1 
ATOM 2478 N NH2   . ARG A 1 370 ? 131.592 107.597 106.287 1.00 65.37  ? 370 ARG A NH2   1 
ATOM 2479 N N     . SER A 1 371 ? 129.121 112.312 108.181 1.00 62.66  ? 371 SER A N     1 
ATOM 2480 C CA    . SER A 1 371 ? 129.147 113.362 109.186 1.00 67.30  ? 371 SER A CA    1 
ATOM 2481 C C     . SER A 1 371 ? 128.698 114.692 108.583 1.00 66.13  ? 371 SER A C     1 
ATOM 2482 O O     . SER A 1 371 ? 128.625 114.858 107.365 1.00 70.55  ? 371 SER A O     1 
ATOM 2483 C CB    . SER A 1 371 ? 130.547 113.494 109.781 1.00 67.38  ? 371 SER A CB    1 
ATOM 2484 O OG    . SER A 1 371 ? 131.182 112.231 109.876 1.00 70.83  ? 371 SER A OG    1 
ATOM 2485 N N     . ALA A 1 372 ? 128.377 115.640 109.464 1.00 48.80  ? 372 ALA A N     1 
ATOM 2486 C CA    . ALA A 1 372 ? 127.875 116.951 109.046 1.00 42.03  ? 372 ALA A CA    1 
ATOM 2487 C C     . ALA A 1 372 ? 128.860 117.794 108.232 1.00 48.80  ? 372 ALA A C     1 
ATOM 2488 O O     . ALA A 1 372 ? 128.409 118.439 107.272 1.00 52.01  ? 372 ALA A O     1 
ATOM 2489 C CB    . ALA A 1 372 ? 127.350 117.715 110.270 1.00 47.24  ? 372 ALA A CB    1 
ATOM 2490 N N     . PRO A 1 373 ? 130.175 117.880 108.543 1.00 59.52  ? 373 PRO A N     1 
ATOM 2491 C CA    . PRO A 1 373 ? 131.080 118.484 107.546 1.00 60.69  ? 373 PRO A CA    1 
ATOM 2492 C C     . PRO A 1 373 ? 131.199 117.670 106.269 1.00 57.86  ? 373 PRO A C     1 
ATOM 2493 O O     . PRO A 1 373 ? 131.363 118.240 105.180 1.00 62.23  ? 373 PRO A O     1 
ATOM 2494 C CB    . PRO A 1 373 ? 132.411 118.577 108.308 1.00 63.31  ? 373 PRO A CB    1 
ATOM 2495 C CG    . PRO A 1 373 ? 132.326 117.475 109.287 1.00 64.50  ? 373 PRO A CG    1 
ATOM 2496 C CD    . PRO A 1 373 ? 130.936 117.660 109.793 1.00 63.46  ? 373 PRO A CD    1 
ATOM 2497 N N     . ASP A 1 374 ? 131.083 116.345 106.374 1.00 44.44  ? 374 ASP A N     1 
ATOM 2498 C CA    . ASP A 1 374 ? 131.122 115.502 105.188 1.00 52.15  ? 374 ASP A CA    1 
ATOM 2499 C C     . ASP A 1 374 ? 129.831 115.693 104.397 1.00 56.21  ? 374 ASP A C     1 
ATOM 2500 O O     . ASP A 1 374 ? 129.848 115.692 103.163 1.00 62.67  ? 374 ASP A O     1 
ATOM 2501 C CB    . ASP A 1 374 ? 131.381 114.049 105.644 1.00 59.82  ? 374 ASP A CB    1 
ATOM 2502 C CG    . ASP A 1 374 ? 131.374 112.977 104.518 1.00 67.88  ? 374 ASP A CG    1 
ATOM 2503 O OD1   . ASP A 1 374 ? 130.637 112.979 103.510 1.00 64.00  ? 374 ASP A OD1   1 
ATOM 2504 O OD2   . ASP A 1 374 ? 132.162 112.026 104.702 1.00 67.53  ? 374 ASP A OD2   1 
ATOM 2505 N N     . ARG A 1 375 ? 128.713 115.920 105.096 1.00 44.16  ? 375 ARG A N     1 
ATOM 2506 C CA    . ARG A 1 375 ? 127.457 116.255 104.426 1.00 37.80  ? 375 ARG A CA    1 
ATOM 2507 C C     . ARG A 1 375 ? 127.533 117.617 103.752 1.00 33.83  ? 375 ARG A C     1 
ATOM 2508 O O     . ARG A 1 375 ? 126.957 117.812 102.678 1.00 35.66  ? 375 ARG A O     1 
ATOM 2509 C CB    . ARG A 1 375 ? 126.302 116.228 105.427 1.00 42.05  ? 375 ARG A CB    1 
ATOM 2510 C CG    . ARG A 1 375 ? 124.984 115.734 104.867 1.00 37.74  ? 375 ARG A CG    1 
ATOM 2511 C CD    . ARG A 1 375 ? 124.221 114.935 105.913 1.00 34.76  ? 375 ARG A CD    1 
ATOM 2512 N NE    . ARG A 1 375 ? 123.174 114.108 105.325 1.00 35.07  ? 375 ARG A NE    1 
ATOM 2513 C CZ    . ARG A 1 375 ? 121.956 114.537 105.028 1.00 37.10  ? 375 ARG A CZ    1 
ATOM 2514 N NH1   . ARG A 1 375 ? 121.588 115.786 105.254 1.00 37.60  ? 375 ARG A NH1   1 
ATOM 2515 N NH2   . ARG A 1 375 ? 121.082 113.690 104.494 1.00 39.81  ? 375 ARG A NH2   1 
ATOM 2516 N N     . GLN A 1 376 ? 128.242 118.565 104.372 1.00 49.49  ? 376 GLN A N     1 
ATOM 2517 C CA    . GLN A 1 376 ? 128.480 119.872 103.764 1.00 56.69  ? 376 GLN A CA    1 
ATOM 2518 C C     . GLN A 1 376 ? 129.256 119.737 102.463 1.00 60.92  ? 376 GLN A C     1 
ATOM 2519 O O     . GLN A 1 376 ? 128.873 120.308 101.434 1.00 57.79  ? 376 GLN A O     1 
ATOM 2520 C CB    . GLN A 1 376 ? 129.261 120.757 104.732 1.00 53.81  ? 376 GLN A CB    1 
ATOM 2521 C CG    . GLN A 1 376 ? 128.452 121.400 105.818 1.00 51.83  ? 376 GLN A CG    1 
ATOM 2522 C CD    . GLN A 1 376 ? 129.249 121.517 107.094 1.00 52.79  ? 376 GLN A CD    1 
ATOM 2523 O OE1   . GLN A 1 376 ? 130.425 121.874 107.073 1.00 51.55  ? 376 GLN A OE1   1 
ATOM 2524 N NE2   . GLN A 1 376 ? 128.625 121.174 108.214 1.00 54.59  ? 376 GLN A NE2   1 
ATOM 2525 N N     . GLU A 1 377 ? 130.333 118.944 102.490 1.00 61.57  ? 377 GLU A N     1 
ATOM 2526 C CA    . GLU A 1 377 ? 131.141 118.731 101.292 1.00 54.83  ? 377 GLU A CA    1 
ATOM 2527 C C     . GLU A 1 377 ? 130.379 117.948 100.226 1.00 59.72  ? 377 GLU A C     1 
ATOM 2528 O O     . GLU A 1 377 ? 130.535 118.217 99.033  1.00 64.39  ? 377 GLU A O     1 
ATOM 2529 C CB    . GLU A 1 377 ? 132.446 118.020 101.654 1.00 55.15  ? 377 GLU A CB    1 
ATOM 2530 C CG    . GLU A 1 377 ? 133.361 118.805 102.595 1.00 53.78  ? 377 GLU A CG    1 
ATOM 2531 C CD    . GLU A 1 377 ? 133.288 120.308 102.387 1.00 60.79  ? 377 GLU A CD    1 
ATOM 2532 O OE1   . GLU A 1 377 ? 133.764 120.797 101.339 1.00 66.54  ? 377 GLU A OE1   1 
ATOM 2533 O OE2   . GLU A 1 377 ? 132.751 121.001 103.275 1.00 63.04  ? 377 GLU A OE2   1 
ATOM 2534 N N     . GLU A 1 378 ? 129.518 117.010 100.635 1.00 51.86  ? 378 GLU A N     1 
ATOM 2535 C CA    . GLU A 1 378 ? 128.779 116.206 99.665  1.00 50.64  ? 378 GLU A CA    1 
ATOM 2536 C C     . GLU A 1 378 ? 127.674 117.007 98.985  1.00 52.08  ? 378 GLU A C     1 
ATOM 2537 O O     . GLU A 1 378 ? 127.507 116.914 97.766  1.00 61.30  ? 378 GLU A O     1 
ATOM 2538 C CB    . GLU A 1 378 ? 128.206 114.960 100.338 1.00 49.42  ? 378 GLU A CB    1 
ATOM 2539 C CG    . GLU A 1 378 ? 129.222 113.841 100.522 1.00 50.17  ? 378 GLU A CG    1 
ATOM 2540 C CD    . GLU A 1 378 ? 128.618 112.464 100.348 1.00 56.17  ? 378 GLU A CD    1 
ATOM 2541 O OE1   . GLU A 1 378 ? 127.385 112.330 100.499 1.00 59.06  ? 378 GLU A OE1   1 
ATOM 2542 O OE2   . GLU A 1 378 ? 129.379 111.514 100.068 1.00 59.79  ? 378 GLU A OE2   1 
ATOM 2543 N N     . ILE A 1 379 ? 126.921 117.813 99.741  1.00 43.01  ? 379 ILE A N     1 
ATOM 2544 C CA    . ILE A 1 379 ? 125.889 118.634 99.109  1.00 47.22  ? 379 ILE A CA    1 
ATOM 2545 C C     . ILE A 1 379 ? 126.518 119.797 98.337  1.00 46.14  ? 379 ILE A C     1 
ATOM 2546 O O     . ILE A 1 379 ? 125.982 120.222 97.306  1.00 51.35  ? 379 ILE A O     1 
ATOM 2547 C CB    . ILE A 1 379 ? 124.856 119.103 100.155 1.00 48.24  ? 379 ILE A CB    1 
ATOM 2548 C CG1   . ILE A 1 379 ? 124.271 117.902 100.892 1.00 47.45  ? 379 ILE A CG1   1 
ATOM 2549 C CG2   . ILE A 1 379 ? 123.673 119.789 99.512  1.00 43.64  ? 379 ILE A CG2   1 
ATOM 2550 C CD1   . ILE A 1 379 ? 123.656 118.255 102.234 1.00 41.76  ? 379 ILE A CD1   1 
ATOM 2551 N N     . SER A 1 380 ? 127.693 120.280 98.758  1.00 49.66  ? 380 SER A N     1 
ATOM 2552 C CA    . SER A 1 380 ? 128.393 121.299 97.977  1.00 55.56  ? 380 SER A CA    1 
ATOM 2553 C C     . SER A 1 380 ? 128.945 120.723 96.672  1.00 59.24  ? 380 SER A C     1 
ATOM 2554 O O     . SER A 1 380 ? 128.873 121.366 95.616  1.00 61.39  ? 380 SER A O     1 
ATOM 2555 C CB    . SER A 1 380 ? 129.509 121.916 98.819  1.00 54.09  ? 380 SER A CB    1 
ATOM 2556 O OG    . SER A 1 380 ? 129.034 122.274 100.106 1.00 53.25  ? 380 SER A OG    1 
ATOM 2557 N N     . LYS A 1 381 ? 129.479 119.495 96.725  1.00 59.57  ? 381 LYS A N     1 
ATOM 2558 C CA    . LYS A 1 381 ? 129.926 118.790 95.527  1.00 54.98  ? 381 LYS A CA    1 
ATOM 2559 C C     . LYS A 1 381 ? 128.760 118.477 94.597  1.00 53.94  ? 381 LYS A C     1 
ATOM 2560 O O     . LYS A 1 381 ? 128.909 118.546 93.373  1.00 57.31  ? 381 LYS A O     1 
ATOM 2561 C CB    . LYS A 1 381 ? 130.673 117.514 95.948  1.00 53.42  ? 381 LYS A CB    1 
ATOM 2562 C CG    . LYS A 1 381 ? 130.623 116.314 94.995  1.00 58.35  ? 381 LYS A CG    1 
ATOM 2563 C CD    . LYS A 1 381 ? 131.514 116.491 93.768  1.00 58.91  ? 381 LYS A CD    1 
ATOM 2564 C CE    . LYS A 1 381 ? 131.582 115.210 92.952  1.00 58.63  ? 381 LYS A CE    1 
ATOM 2565 N NZ    . LYS A 1 381 ? 130.324 114.960 92.198  1.00 58.11  ? 381 LYS A NZ    1 
ATOM 2566 N N     . LEU A 1 382 ? 127.594 118.152 95.160  1.00 49.24  ? 382 LEU A N     1 
ATOM 2567 C CA    . LEU A 1 382 ? 126.407 117.903 94.349  1.00 48.77  ? 382 LEU A CA    1 
ATOM 2568 C C     . LEU A 1 382 ? 125.904 119.190 93.707  1.00 46.33  ? 382 LEU A C     1 
ATOM 2569 O O     . LEU A 1 382 ? 125.447 119.187 92.561  1.00 48.08  ? 382 LEU A O     1 
ATOM 2570 C CB    . LEU A 1 382 ? 125.322 117.277 95.220  1.00 48.97  ? 382 LEU A CB    1 
ATOM 2571 C CG    . LEU A 1 382 ? 123.898 117.021 94.728  1.00 48.55  ? 382 LEU A CG    1 
ATOM 2572 C CD1   . LEU A 1 382 ? 123.826 116.390 93.343  1.00 51.81  ? 382 LEU A CD1   1 
ATOM 2573 C CD2   . LEU A 1 382 ? 123.227 116.149 95.742  1.00 51.63  ? 382 LEU A CD2   1 
ATOM 2574 N N     . MET A 1 383 ? 125.978 120.304 94.434  1.00 50.64  ? 383 MET A N     1 
ATOM 2575 C CA    . MET A 1 383 ? 125.542 121.577 93.881  1.00 56.70  ? 383 MET A CA    1 
ATOM 2576 C C     . MET A 1 383 ? 126.519 122.095 92.834  1.00 62.22  ? 383 MET A C     1 
ATOM 2577 O O     . MET A 1 383 ? 126.124 122.869 91.956  1.00 63.50  ? 383 MET A O     1 
ATOM 2578 C CB    . MET A 1 383 ? 125.393 122.595 95.007  1.00 58.27  ? 383 MET A CB    1 
ATOM 2579 C CG    . MET A 1 383 ? 124.283 123.616 94.826  1.00 56.98  ? 383 MET A CG    1 
ATOM 2580 S SD    . MET A 1 383 ? 122.670 122.851 94.585  1.00 47.51  ? 383 MET A SD    1 
ATOM 2581 C CE    . MET A 1 383 ? 121.828 124.126 93.670  1.00 52.01  ? 383 MET A CE    1 
ATOM 2582 N N     . ARG A 1 384 ? 127.788 121.687 92.916  1.00 66.15  ? 384 ARG A N     1 
ATOM 2583 C CA    . ARG A 1 384 ? 128.764 122.030 91.886  1.00 61.36  ? 384 ARG A CA    1 
ATOM 2584 C C     . ARG A 1 384 ? 128.615 121.142 90.651  1.00 66.96  ? 384 ARG A C     1 
ATOM 2585 O O     . ARG A 1 384 ? 128.576 121.635 89.519  1.00 70.03  ? 384 ARG A O     1 
ATOM 2586 C CB    . ARG A 1 384 ? 130.183 121.908 92.453  1.00 64.01  ? 384 ARG A CB    1 
ATOM 2587 C CG    . ARG A 1 384 ? 130.647 123.090 93.290  1.00 70.07  ? 384 ARG A CG    1 
ATOM 2588 C CD    . ARG A 1 384 ? 132.147 123.019 93.570  1.00 70.97  ? 384 ARG A CD    1 
ATOM 2589 N NE    . ARG A 1 384 ? 132.674 121.664 93.450  1.00 71.75  ? 384 ARG A NE    1 
ATOM 2590 C CZ    . ARG A 1 384 ? 132.992 120.886 94.476  1.00 68.66  ? 384 ARG A CZ    1 
ATOM 2591 N NH1   . ARG A 1 384 ? 132.854 121.298 95.726  1.00 66.15  ? 384 ARG A NH1   1 
ATOM 2592 N NH2   . ARG A 1 384 ? 133.462 119.663 94.243  1.00 65.42  ? 384 ARG A NH2   1 
ATOM 2593 N N     . SER A 1 385 ? 128.534 119.825 90.858  1.00 64.75  ? 385 SER A N     1 
ATOM 2594 C CA    . SER A 1 385 ? 128.665 118.876 89.756  1.00 62.68  ? 385 SER A CA    1 
ATOM 2595 C C     . SER A 1 385 ? 127.384 118.764 88.939  1.00 61.65  ? 385 SER A C     1 
ATOM 2596 O O     . SER A 1 385 ? 127.441 118.605 87.714  1.00 60.87  ? 385 SER A O     1 
ATOM 2597 C CB    . SER A 1 385 ? 129.074 117.506 90.295  1.00 60.78  ? 385 SER A CB    1 
ATOM 2598 O OG    . SER A 1 385 ? 128.090 116.989 91.173  1.00 62.20  ? 385 SER A OG    1 
ATOM 2599 N N     . ALA A 1 386 ? 126.221 118.812 89.596  1.00 64.41  ? 386 ALA A N     1 
ATOM 2600 C CA    . ALA A 1 386 ? 124.963 118.732 88.858  1.00 65.65  ? 386 ALA A CA    1 
ATOM 2601 C C     . ALA A 1 386 ? 124.714 120.008 88.068  1.00 65.68  ? 386 ALA A C     1 
ATOM 2602 O O     . ALA A 1 386 ? 124.186 119.950 86.950  1.00 70.18  ? 386 ALA A O     1 
ATOM 2603 C CB    . ALA A 1 386 ? 123.799 118.444 89.804  1.00 64.91  ? 386 ALA A CB    1 
ATOM 2604 N N     . SER A 1 387 ? 125.099 121.157 88.638  1.00 57.84  ? 387 SER A N     1 
ATOM 2605 C CA    . SER A 1 387 ? 125.171 122.463 87.971  1.00 61.26  ? 387 SER A CA    1 
ATOM 2606 C C     . SER A 1 387 ? 123.816 122.896 87.416  1.00 58.27  ? 387 SER A C     1 
ATOM 2607 O O     . SER A 1 387 ? 123.599 122.964 86.207  1.00 64.11  ? 387 SER A O     1 
ATOM 2608 C CB    . SER A 1 387 ? 126.238 122.466 86.873  1.00 64.08  ? 387 SER A CB    1 
ATOM 2609 O OG    . SER A 1 387 ? 127.422 121.822 87.304  1.00 66.03  ? 387 SER A OG    1 
ATOM 2610 N N     . PHE A 1 388 ? 122.888 123.153 88.335  1.00 47.30  ? 388 PHE A N     1 
ATOM 2611 C CA    . PHE A 1 388 ? 121.516 123.464 87.958  1.00 51.83  ? 388 PHE A CA    1 
ATOM 2612 C C     . PHE A 1 388 ? 121.368 124.814 87.262  1.00 58.13  ? 388 PHE A C     1 
ATOM 2613 O O     . PHE A 1 388 ? 120.330 125.064 86.641  1.00 61.35  ? 388 PHE A O     1 
ATOM 2614 C CB    . PHE A 1 388 ? 120.619 123.427 89.186  1.00 54.09  ? 388 PHE A CB    1 
ATOM 2615 C CG    . PHE A 1 388 ? 120.593 122.099 89.899  1.00 57.75  ? 388 PHE A CG    1 
ATOM 2616 C CD1   . PHE A 1 388 ? 121.475 121.823 90.933  1.00 60.82  ? 388 PHE A CD1   1 
ATOM 2617 C CD2   . PHE A 1 388 ? 119.661 121.136 89.547  1.00 58.46  ? 388 PHE A CD2   1 
ATOM 2618 C CE1   . PHE A 1 388 ? 121.433 120.610 91.599  1.00 60.22  ? 388 PHE A CE1   1 
ATOM 2619 C CE2   . PHE A 1 388 ? 119.616 119.917 90.205  1.00 55.88  ? 388 PHE A CE2   1 
ATOM 2620 C CZ    . PHE A 1 388 ? 120.505 119.655 91.235  1.00 57.84  ? 388 PHE A CZ    1 
ATOM 2621 N N     . ASN A 1 389 ? 122.361 125.699 87.367  1.00 69.20  ? 389 ASN A N     1 
ATOM 2622 C CA    . ASN A 1 389 ? 122.362 126.892 86.526  1.00 69.35  ? 389 ASN A CA    1 
ATOM 2623 C C     . ASN A 1 389 ? 122.726 126.541 85.089  1.00 68.49  ? 389 ASN A C     1 
ATOM 2624 O O     . ASN A 1 389 ? 122.209 127.144 84.141  1.00 67.68  ? 389 ASN A O     1 
ATOM 2625 C CB    . ASN A 1 389 ? 123.329 127.932 87.086  1.00 67.13  ? 389 ASN A CB    1 
ATOM 2626 C CG    . ASN A 1 389 ? 122.921 128.418 88.454  1.00 67.95  ? 389 ASN A CG    1 
ATOM 2627 O OD1   . ASN A 1 389 ? 121.810 128.908 88.642  1.00 67.85  ? 389 ASN A OD1   1 
ATOM 2628 N ND2   . ASN A 1 389 ? 123.822 128.287 89.420  1.00 63.27  ? 389 ASN A ND2   1 
ATOM 2629 N N     . THR A 1 390 ? 123.606 125.557 84.913  1.00 76.87  ? 390 THR A N     1 
ATOM 2630 C CA    . THR A 1 390 ? 124.025 125.070 83.605  1.00 78.04  ? 390 THR A CA    1 
ATOM 2631 C C     . THR A 1 390 ? 122.996 124.109 83.003  1.00 80.37  ? 390 THR A C     1 
ATOM 2632 O O     . THR A 1 390 ? 123.109 123.746 81.826  1.00 82.76  ? 390 THR A O     1 
ATOM 2633 C CB    . THR A 1 390 ? 125.404 124.402 83.750  1.00 76.28  ? 390 THR A CB    1 
ATOM 2634 O OG1   . THR A 1 390 ? 126.182 125.148 84.692  1.00 79.08  ? 390 THR A OG1   1 
ATOM 2635 C CG2   . THR A 1 390 ? 126.191 124.423 82.438  1.00 76.83  ? 390 THR A CG2   1 
ATOM 2636 N N     . ASP A 1 391 ? 121.991 123.711 83.786  1.00 81.01  ? 391 ASP A N     1 
ATOM 2637 C CA    . ASP A 1 391 ? 120.853 122.925 83.318  1.00 76.91  ? 391 ASP A CA    1 
ATOM 2638 C C     . ASP A 1 391 ? 120.088 123.714 82.262  1.00 79.94  ? 391 ASP A C     1 
ATOM 2639 O O     . ASP A 1 391 ? 119.698 124.861 82.523  1.00 80.04  ? 391 ASP A O     1 
ATOM 2640 C CB    . ASP A 1 391 ? 119.943 122.589 84.500  1.00 77.76  ? 391 ASP A CB    1 
ATOM 2641 C CG    . ASP A 1 391 ? 118.990 121.445 84.216  1.00 80.42  ? 391 ASP A CG    1 
ATOM 2642 O OD1   . ASP A 1 391 ? 118.085 121.606 83.372  1.00 82.38  ? 391 ASP A OD1   1 
ATOM 2643 O OD2   . ASP A 1 391 ? 119.132 120.387 84.861  1.00 81.13  ? 391 ASP A OD2   1 
ATOM 2644 N N     . PRO A 1 392 ? 119.872 123.158 81.065  1.00 84.90  ? 392 PRO A N     1 
ATOM 2645 C CA    . PRO A 1 392 ? 119.358 123.971 79.954  1.00 88.57  ? 392 PRO A CA    1 
ATOM 2646 C C     . PRO A 1 392 ? 117.887 124.333 80.078  1.00 87.06  ? 392 PRO A C     1 
ATOM 2647 O O     . PRO A 1 392 ? 117.511 125.490 79.858  1.00 89.05  ? 392 PRO A O     1 
ATOM 2648 C CB    . PRO A 1 392 ? 119.618 123.086 78.726  1.00 87.67  ? 392 PRO A CB    1 
ATOM 2649 C CG    . PRO A 1 392 ? 119.671 121.688 79.259  1.00 84.78  ? 392 PRO A CG    1 
ATOM 2650 C CD    . PRO A 1 392 ? 120.215 121.785 80.653  1.00 82.68  ? 392 PRO A CD    1 
ATOM 2651 N N     . TYR A 1 393 ? 117.045 123.371 80.452  1.00 79.02  ? 393 TYR A N     1 
ATOM 2652 C CA    . TYR A 1 393 ? 115.618 123.642 80.428  1.00 79.59  ? 393 TYR A CA    1 
ATOM 2653 C C     . TYR A 1 393 ? 115.203 124.415 81.668  1.00 79.52  ? 393 TYR A C     1 
ATOM 2654 O O     . TYR A 1 393 ? 114.185 125.115 81.640  1.00 78.93  ? 393 TYR A O     1 
ATOM 2655 C CB    . TYR A 1 393 ? 114.802 122.346 80.332  1.00 81.83  ? 393 TYR A CB    1 
ATOM 2656 C CG    . TYR A 1 393 ? 115.147 121.433 79.157  1.00 80.45  ? 393 TYR A CG    1 
ATOM 2657 C CD1   . TYR A 1 393 ? 115.652 121.935 77.957  1.00 80.29  ? 393 TYR A CD1   1 
ATOM 2658 C CD2   . TYR A 1 393 ? 114.885 120.067 79.229  1.00 80.76  ? 393 TYR A CD2   1 
ATOM 2659 C CE1   . TYR A 1 393 ? 115.973 121.089 76.901  1.00 82.38  ? 393 TYR A CE1   1 
ATOM 2660 C CE2   . TYR A 1 393 ? 115.169 119.222 78.167  1.00 81.21  ? 393 TYR A CE2   1 
ATOM 2661 C CZ    . TYR A 1 393 ? 115.708 119.740 77.007  1.00 82.61  ? 393 TYR A CZ    1 
ATOM 2662 O OH    . TYR A 1 393 ? 115.999 118.907 75.950  1.00 80.58  ? 393 TYR A OH    1 
ATOM 2663 N N     . VAL A 1 394 ? 115.988 124.298 82.743  1.00 80.11  ? 394 VAL A N     1 
ATOM 2664 C CA    . VAL A 1 394 ? 115.745 125.050 83.970  1.00 81.11  ? 394 VAL A CA    1 
ATOM 2665 C C     . VAL A 1 394 ? 116.014 126.535 83.741  1.00 78.89  ? 394 VAL A C     1 
ATOM 2666 O O     . VAL A 1 394 ? 115.194 127.393 84.092  1.00 76.81  ? 394 VAL A O     1 
ATOM 2667 C CB    . VAL A 1 394 ? 116.612 124.475 85.108  1.00 77.83  ? 394 VAL A CB    1 
ATOM 2668 C CG1   . VAL A 1 394 ? 116.749 125.452 86.264  1.00 76.11  ? 394 VAL A CG1   1 
ATOM 2669 C CG2   . VAL A 1 394 ? 116.055 123.144 85.575  1.00 73.61  ? 394 VAL A CG2   1 
ATOM 2670 N N     . ARG A 1 395 ? 117.149 126.859 83.109  1.00 78.57  ? 395 ARG A N     1 
ATOM 2671 C CA    . ARG A 1 395 ? 117.440 128.255 82.796  1.00 81.29  ? 395 ARG A CA    1 
ATOM 2672 C C     . ARG A 1 395 ? 116.590 128.751 81.634  1.00 84.26  ? 395 ARG A C     1 
ATOM 2673 O O     . ARG A 1 395 ? 116.421 129.964 81.466  1.00 86.25  ? 395 ARG A O     1 
ATOM 2674 C CB    . ARG A 1 395 ? 118.929 128.446 82.493  1.00 83.22  ? 395 ARG A CB    1 
ATOM 2675 C CG    . ARG A 1 395 ? 119.396 127.871 81.167  1.00 84.10  ? 395 ARG A CG    1 
ATOM 2676 C CD    . ARG A 1 395 ? 120.613 128.605 80.617  1.00 85.18  ? 395 ARG A CD    1 
ATOM 2677 N NE    . ARG A 1 395 ? 121.621 128.861 81.639  1.00 86.16  ? 395 ARG A NE    1 
ATOM 2678 C CZ    . ARG A 1 395 ? 122.855 129.274 81.383  1.00 84.75  ? 395 ARG A CZ    1 
ATOM 2679 N NH1   . ARG A 1 395 ? 123.267 129.497 80.146  1.00 85.83  ? 395 ARG A NH1   1 
ATOM 2680 N NH2   . ARG A 1 395 ? 123.697 129.467 82.394  1.00 83.23  ? 395 ARG A NH2   1 
ATOM 2681 N N     . GLU A 1 396 ? 116.052 127.837 80.823  1.00 91.00  ? 396 GLU A N     1 
ATOM 2682 C CA    . GLU A 1 396 ? 115.035 128.228 79.856  1.00 93.28  ? 396 GLU A CA    1 
ATOM 2683 C C     . GLU A 1 396 ? 113.709 128.511 80.555  1.00 91.73  ? 396 GLU A C     1 
ATOM 2684 O O     . GLU A 1 396 ? 112.947 129.384 80.123  1.00 92.46  ? 396 GLU A O     1 
ATOM 2685 C CB    . GLU A 1 396 ? 114.901 127.134 78.790  1.00 93.84  ? 396 GLU A CB    1 
ATOM 2686 C CG    . GLU A 1 396 ? 113.782 127.313 77.774  1.00 93.15  ? 396 GLU A CG    1 
ATOM 2687 C CD    . GLU A 1 396 ? 113.377 126.003 77.137  1.00 95.90  ? 396 GLU A CD    1 
ATOM 2688 O OE1   . GLU A 1 396 ? 112.899 125.117 77.872  1.00 98.49  ? 396 GLU A OE1   1 
ATOM 2689 O OE2   . GLU A 1 396 ? 113.528 125.863 75.906  1.00 94.46  ? 396 GLU A OE2   1 
ATOM 2690 N N     . PHE A 1 397 ? 113.452 127.837 81.679  1.00 79.25  ? 397 PHE A N     1 
ATOM 2691 C CA    . PHE A 1 397 ? 112.228 128.046 82.446  1.00 79.89  ? 397 PHE A CA    1 
ATOM 2692 C C     . PHE A 1 397 ? 112.249 129.318 83.289  1.00 82.14  ? 397 PHE A C     1 
ATOM 2693 O O     . PHE A 1 397 ? 111.276 129.574 84.006  1.00 80.61  ? 397 PHE A O     1 
ATOM 2694 C CB    . PHE A 1 397 ? 111.969 126.849 83.365  1.00 81.30  ? 397 PHE A CB    1 
ATOM 2695 C CG    . PHE A 1 397 ? 110.984 125.856 82.817  1.00 83.12  ? 397 PHE A CG    1 
ATOM 2696 C CD1   . PHE A 1 397 ? 110.944 125.567 81.461  1.00 81.82  ? 397 PHE A CD1   1 
ATOM 2697 C CD2   . PHE A 1 397 ? 110.098 125.209 83.663  1.00 79.22  ? 397 PHE A CD2   1 
ATOM 2698 C CE1   . PHE A 1 397 ? 110.036 124.646 80.963  1.00 81.46  ? 397 PHE A CE1   1 
ATOM 2699 C CE2   . PHE A 1 397 ? 109.187 124.294 83.173  1.00 78.46  ? 397 PHE A CE2   1 
ATOM 2700 C CZ    . PHE A 1 397 ? 109.156 124.012 81.821  1.00 79.75  ? 397 PHE A CZ    1 
ATOM 2701 N N     . GLY A 1 398 ? 113.319 130.107 83.240  1.00 88.26  ? 398 GLY A N     1 
ATOM 2702 C CA    . GLY A 1 398 ? 113.423 131.295 84.057  1.00 85.05  ? 398 GLY A CA    1 
ATOM 2703 C C     . GLY A 1 398 ? 113.947 131.061 85.452  1.00 85.02  ? 398 GLY A C     1 
ATOM 2704 O O     . GLY A 1 398 ? 113.924 131.988 86.268  1.00 89.51  ? 398 GLY A O     1 
ATOM 2705 N N     . ILE A 1 399 ? 114.426 129.860 85.749  1.00 83.44  ? 399 ILE A N     1 
ATOM 2706 C CA    . ILE A 1 399 ? 114.887 129.495 87.081  1.00 83.11  ? 399 ILE A CA    1 
ATOM 2707 C C     . ILE A 1 399 ? 116.408 129.472 87.083  1.00 81.86  ? 399 ILE A C     1 
ATOM 2708 O O     . ILE A 1 399 ? 117.028 128.780 86.267  1.00 82.83  ? 399 ILE A O     1 
ATOM 2709 C CB    . ILE A 1 399 ? 114.320 128.130 87.505  1.00 84.52  ? 399 ILE A CB    1 
ATOM 2710 C CG1   . ILE A 1 399 ? 112.789 128.150 87.474  1.00 83.19  ? 399 ILE A CG1   1 
ATOM 2711 C CG2   . ILE A 1 399 ? 114.860 127.714 88.869  1.00 82.88  ? 399 ILE A CG2   1 
ATOM 2712 C CD1   . ILE A 1 399 ? 112.156 128.904 88.608  1.00 79.42  ? 399 ILE A CD1   1 
ATOM 2713 N N     . MET A 1 400 ? 117.008 130.235 87.989  1.00 70.49  ? 400 MET A N     1 
ATOM 2714 C CA    . MET A 1 400 ? 118.429 130.130 88.271  1.00 69.97  ? 400 MET A CA    1 
ATOM 2715 C C     . MET A 1 400 ? 118.614 130.059 89.778  1.00 74.75  ? 400 MET A C     1 
ATOM 2716 O O     . MET A 1 400 ? 117.828 130.626 90.540  1.00 78.04  ? 400 MET A O     1 
ATOM 2717 C CB    . MET A 1 400 ? 119.239 131.296 87.671  1.00 72.10  ? 400 MET A CB    1 
ATOM 2718 C CG    . MET A 1 400 ? 118.854 132.684 88.160  1.00 73.30  ? 400 MET A CG    1 
ATOM 2719 S SD    . MET A 1 400 ? 117.119 133.066 87.865  1.00 81.95  ? 400 MET A SD    1 
ATOM 2720 C CE    . MET A 1 400 ? 117.077 133.035 86.074  1.00 77.03  ? 400 MET A CE    1 
ATOM 2721 N N     . VAL A 1 401 ? 119.645 129.333 90.200  1.00 68.83  ? 401 VAL A N     1 
ATOM 2722 C CA    . VAL A 1 401 ? 119.915 129.105 91.611  1.00 63.93  ? 401 VAL A CA    1 
ATOM 2723 C C     . VAL A 1 401 ? 121.194 129.838 91.999  1.00 66.46  ? 401 VAL A C     1 
ATOM 2724 O O     . VAL A 1 401 ? 121.922 130.362 91.157  1.00 75.97  ? 401 VAL A O     1 
ATOM 2725 C CB    . VAL A 1 401 ? 120.019 127.604 91.944  1.00 61.92  ? 401 VAL A CB    1 
ATOM 2726 C CG1   . VAL A 1 401 ? 118.853 126.849 91.352  1.00 63.74  ? 401 VAL A CG1   1 
ATOM 2727 C CG2   . VAL A 1 401 ? 121.312 127.042 91.407  1.00 62.65  ? 401 VAL A CG2   1 
ATOM 2728 N N     . LYS A 1 402 ? 121.457 129.882 93.300  1.00 52.11  ? 402 LYS A N     1 
ATOM 2729 C CA    . LYS A 1 402 ? 122.728 130.354 93.839  1.00 58.81  ? 402 LYS A CA    1 
ATOM 2730 C C     . LYS A 1 402 ? 123.343 129.150 94.536  1.00 58.25  ? 402 LYS A C     1 
ATOM 2731 O O     . LYS A 1 402 ? 122.752 128.602 95.470  1.00 59.33  ? 402 LYS A O     1 
ATOM 2732 C CB    . LYS A 1 402 ? 122.530 131.530 94.789  1.00 54.14  ? 402 LYS A CB    1 
ATOM 2733 C CG    . LYS A 1 402 ? 123.645 132.560 94.755  1.00 54.59  ? 402 LYS A CG    1 
ATOM 2734 C CD    . LYS A 1 402 ? 123.192 133.873 95.373  1.00 58.05  ? 402 LYS A CD    1 
ATOM 2735 C CE    . LYS A 1 402 ? 124.375 134.736 95.767  1.00 60.23  ? 402 LYS A CE    1 
ATOM 2736 N NZ    . LYS A 1 402 ? 125.430 134.733 94.719  1.00 65.59  ? 402 LYS A NZ    1 
ATOM 2737 N N     . ASP A 1 403 ? 124.528 128.747 94.072  1.00 64.33  ? 403 ASP A N     1 
ATOM 2738 C CA    . ASP A 1 403 ? 125.162 127.513 94.520  1.00 59.59  ? 403 ASP A CA    1 
ATOM 2739 C C     . ASP A 1 403 ? 125.633 127.664 95.966  1.00 60.77  ? 403 ASP A C     1 
ATOM 2740 O O     . ASP A 1 403 ? 125.616 126.682 96.716  1.00 59.19  ? 403 ASP A O     1 
ATOM 2741 C CB    . ASP A 1 403 ? 126.276 127.204 93.478  1.00 67.15  ? 403 ASP A CB    1 
ATOM 2742 C CG    . ASP A 1 403 ? 127.347 126.145 93.892  1.00 67.80  ? 403 ASP A CG    1 
ATOM 2743 O OD1   . ASP A 1 403 ? 127.310 125.419 94.906  1.00 62.32  ? 403 ASP A OD1   1 
ATOM 2744 O OD2   . ASP A 1 403 ? 128.314 126.042 93.109  1.00 70.71  ? 403 ASP A OD2   1 
ATOM 2745 N N     . GLU A 1 404 ? 125.939 128.895 96.389  1.00 55.44  ? 404 GLU A N     1 
ATOM 2746 C CA    . GLU A 1 404 ? 126.491 129.155 97.714  1.00 56.27  ? 404 GLU A CA    1 
ATOM 2747 C C     . GLU A 1 404 ? 125.478 128.863 98.817  1.00 53.14  ? 404 GLU A C     1 
ATOM 2748 O O     . GLU A 1 404 ? 124.271 129.050 98.643  1.00 48.02  ? 404 GLU A O     1 
ATOM 2749 C CB    . GLU A 1 404 ? 126.946 130.613 97.812  1.00 54.67  ? 404 GLU A CB    1 
ATOM 2750 C CG    . GLU A 1 404 ? 127.864 131.078 96.690  1.00 53.07  ? 404 GLU A CG    1 
ATOM 2751 C CD    . GLU A 1 404 ? 129.327 130.789 96.959  1.00 54.68  ? 404 GLU A CD    1 
ATOM 2752 O OE1   . GLU A 1 404 ? 130.101 131.757 97.110  1.00 54.88  ? 404 GLU A OE1   1 
ATOM 2753 O OE2   . GLU A 1 404 ? 129.710 129.601 97.004  1.00 56.51  ? 404 GLU A OE2   1 
ATOM 2754 N N     . MET A 1 405 ? 125.989 128.373 99.946  1.00 46.29  ? 405 MET A N     1 
ATOM 2755 C CA    . MET A 1 405 ? 125.162 128.094 101.111 1.00 46.73  ? 405 MET A CA    1 
ATOM 2756 C C     . MET A 1 405 ? 124.631 129.396 101.698 1.00 53.56  ? 405 MET A C     1 
ATOM 2757 O O     . MET A 1 405 ? 125.309 130.428 101.693 1.00 48.97  ? 405 MET A O     1 
ATOM 2758 C CB    . MET A 1 405 ? 125.971 127.338 102.165 1.00 48.87  ? 405 MET A CB    1 
ATOM 2759 C CG    . MET A 1 405 ? 126.158 125.851 101.905 1.00 40.90  ? 405 MET A CG    1 
ATOM 2760 S SD    . MET A 1 405 ? 124.800 124.836 102.507 1.00 41.82  ? 405 MET A SD    1 
ATOM 2761 C CE    . MET A 1 405 ? 125.570 123.220 102.561 1.00 40.75  ? 405 MET A CE    1 
ATOM 2762 N N     . THR A 1 406 ? 123.406 129.340 102.208 1.00 56.15  ? 406 THR A N     1 
ATOM 2763 C CA    . THR A 1 406 ? 122.676 130.532 102.608 1.00 53.48  ? 406 THR A CA    1 
ATOM 2764 C C     . THR A 1 406 ? 123.190 131.099 103.928 1.00 49.30  ? 406 THR A C     1 
ATOM 2765 O O     . THR A 1 406 ? 124.026 130.509 104.613 1.00 46.06  ? 406 THR A O     1 
ATOM 2766 C CB    . THR A 1 406 ? 121.185 130.230 102.729 1.00 44.60  ? 406 THR A CB    1 
ATOM 2767 O OG1   . THR A 1 406 ? 120.467 131.460 102.868 1.00 44.26  ? 406 THR A OG1   1 
ATOM 2768 C CG2   . THR A 1 406 ? 120.917 129.359 103.942 1.00 47.02  ? 406 THR A CG2   1 
ATOM 2769 N N     . ASP A 1 407 ? 122.684 132.282 104.267 1.00 45.04  ? 407 ASP A N     1 
ATOM 2770 C CA    . ASP A 1 407 ? 122.911 132.911 105.559 1.00 43.62  ? 407 ASP A CA    1 
ATOM 2771 C C     . ASP A 1 407 ? 121.574 133.021 106.276 1.00 42.24  ? 407 ASP A C     1 
ATOM 2772 O O     . ASP A 1 407 ? 120.687 133.756 105.829 1.00 41.08  ? 407 ASP A O     1 
ATOM 2773 C CB    . ASP A 1 407 ? 123.546 134.296 105.398 1.00 36.96  ? 407 ASP A CB    1 
ATOM 2774 C CG    . ASP A 1 407 ? 124.707 134.300 104.420 1.00 42.85  ? 407 ASP A CG    1 
ATOM 2775 O OD1   . ASP A 1 407 ? 125.549 133.381 104.484 1.00 44.80  ? 407 ASP A OD1   1 
ATOM 2776 O OD2   . ASP A 1 407 ? 124.779 135.227 103.588 1.00 46.16  ? 407 ASP A OD2   1 
ATOM 2777 N N     . VAL A 1 408 ? 121.425 132.289 107.380 1.00 40.99  ? 408 VAL A N     1 
ATOM 2778 C CA    . VAL A 1 408 ? 120.176 132.263 108.130 1.00 36.69  ? 408 VAL A CA    1 
ATOM 2779 C C     . VAL A 1 408 ? 120.455 132.668 109.576 1.00 38.40  ? 408 VAL A C     1 
ATOM 2780 O O     . VAL A 1 408 ? 121.495 132.317 110.145 1.00 35.55  ? 408 VAL A O     1 
ATOM 2781 C CB    . VAL A 1 408 ? 119.473 130.883 108.012 1.00 34.73  ? 408 VAL A CB    1 
ATOM 2782 C CG1   . VAL A 1 408 ? 120.239 129.745 108.693 1.00 34.60  ? 408 VAL A CG1   1 
ATOM 2783 C CG2   . VAL A 1 408 ? 118.055 130.958 108.514 1.00 31.37  ? 408 VAL A CG2   1 
ATOM 2784 N N     . THR A 1 409 ? 119.556 133.472 110.144 1.00 42.18  ? 409 THR A N     1 
ATOM 2785 C CA    . THR A 1 409 ? 119.726 134.047 111.472 1.00 35.40  ? 409 THR A CA    1 
ATOM 2786 C C     . THR A 1 409 ? 118.994 133.178 112.490 1.00 41.16  ? 409 THR A C     1 
ATOM 2787 O O     . THR A 1 409 ? 117.782 132.960 112.372 1.00 41.95  ? 409 THR A O     1 
ATOM 2788 C CB    . THR A 1 409 ? 119.218 135.491 111.494 1.00 39.85  ? 409 THR A CB    1 
ATOM 2789 O OG1   . THR A 1 409 ? 120.195 136.341 110.883 1.00 43.96  ? 409 THR A OG1   1 
ATOM 2790 C CG2   . THR A 1 409 ? 118.983 135.979 112.914 1.00 42.28  ? 409 THR A CG2   1 
ATOM 2791 N N     . GLY A 1 410 ? 119.736 132.671 113.473 1.00 38.13  ? 410 GLY A N     1 
ATOM 2792 C CA    . GLY A 1 410 ? 119.194 131.745 114.447 1.00 25.92  ? 410 GLY A CA    1 
ATOM 2793 C C     . GLY A 1 410 ? 119.348 132.219 115.874 1.00 30.85  ? 410 GLY A C     1 
ATOM 2794 O O     . GLY A 1 410 ? 119.720 133.370 116.105 1.00 36.00  ? 410 GLY A O     1 
ATOM 2795 N N     . ARG A 1 411 ? 119.081 131.342 116.842 1.00 30.17  ? 411 ARG A N     1 
ATOM 2796 C CA    . ARG A 1 411 ? 119.000 131.738 118.246 1.00 24.14  ? 411 ARG A CA    1 
ATOM 2797 C C     . ARG A 1 411 ? 119.440 130.574 119.122 1.00 20.19  ? 411 ARG A C     1 
ATOM 2798 O O     . ARG A 1 411 ? 118.617 129.729 119.479 1.00 21.30  ? 411 ARG A O     1 
ATOM 2799 C CB    . ARG A 1 411 ? 117.575 132.163 118.584 1.00 13.85  ? 411 ARG A CB    1 
ATOM 2800 C CG    . ARG A 1 411 ? 117.355 133.644 118.447 1.00 32.03  ? 411 ARG A CG    1 
ATOM 2801 C CD    . ARG A 1 411 ? 115.978 134.042 118.929 1.00 25.95  ? 411 ARG A CD    1 
ATOM 2802 N NE    . ARG A 1 411 ? 114.880 133.245 118.392 1.00 17.73  ? 411 ARG A NE    1 
ATOM 2803 C CZ    . ARG A 1 411 ? 114.478 133.219 117.126 1.00 21.66  ? 411 ARG A CZ    1 
ATOM 2804 N NH1   . ARG A 1 411 ? 114.981 134.035 116.212 1.00 29.23  ? 411 ARG A NH1   1 
ATOM 2805 N NH2   . ARG A 1 411 ? 113.514 132.375 116.773 1.00 31.76  ? 411 ARG A NH2   1 
ATOM 2806 N N     . VAL A 1 412 ? 120.722 130.537 119.478 1.00 24.29  ? 412 VAL A N     1 
ATOM 2807 C CA    . VAL A 1 412 ? 121.245 129.497 120.359 1.00 20.08  ? 412 VAL A CA    1 
ATOM 2808 C C     . VAL A 1 412 ? 120.814 129.799 121.786 1.00 33.00  ? 412 VAL A C     1 
ATOM 2809 O O     . VAL A 1 412 ? 120.819 130.957 122.217 1.00 38.46  ? 412 VAL A O     1 
ATOM 2810 C CB    . VAL A 1 412 ? 122.772 129.404 120.253 1.00 18.37  ? 412 VAL A CB    1 
ATOM 2811 C CG1   . VAL A 1 412 ? 123.263 128.053 120.747 1.00 19.34  ? 412 VAL A CG1   1 
ATOM 2812 C CG2   . VAL A 1 412 ? 123.202 129.636 118.839 1.00 26.42  ? 412 VAL A CG2   1 
ATOM 2813 N N     . LEU A 1 413 ? 120.459 128.757 122.529 1.00 32.49  ? 413 LEU A N     1 
ATOM 2814 C CA    . LEU A 1 413 ? 119.814 128.909 123.824 1.00 26.70  ? 413 LEU A CA    1 
ATOM 2815 C C     . LEU A 1 413 ? 120.705 128.399 124.947 1.00 24.88  ? 413 LEU A C     1 
ATOM 2816 O O     . LEU A 1 413 ? 121.433 127.416 124.774 1.00 19.48  ? 413 LEU A O     1 
ATOM 2817 C CB    . LEU A 1 413 ? 118.476 128.177 123.846 1.00 25.50  ? 413 LEU A CB    1 
ATOM 2818 C CG    . LEU A 1 413 ? 117.246 129.069 123.731 1.00 18.32  ? 413 LEU A CG    1 
ATOM 2819 C CD1   . LEU A 1 413 ? 117.302 129.943 122.502 1.00 20.38  ? 413 LEU A CD1   1 
ATOM 2820 C CD2   . LEU A 1 413 ? 116.018 128.203 123.705 1.00 30.80  ? 413 LEU A CD2   1 
ATOM 2821 N N     . GLN A 1 414 ? 120.648 129.091 126.079 1.00 37.43  ? 414 GLN A N     1 
ATOM 2822 C CA    . GLN A 1 414 ? 121.298 128.654 127.309 1.00 38.57  ? 414 GLN A CA    1 
ATOM 2823 C C     . GLN A 1 414 ? 120.555 127.438 127.852 1.00 32.27  ? 414 GLN A C     1 
ATOM 2824 O O     . GLN A 1 414 ? 119.350 127.533 128.119 1.00 27.79  ? 414 GLN A O     1 
ATOM 2825 C CB    . GLN A 1 414 ? 121.257 129.838 128.293 1.00 39.31  ? 414 GLN A CB    1 
ATOM 2826 C CG    . GLN A 1 414 ? 121.491 129.670 129.812 1.00 40.57  ? 414 GLN A CG    1 
ATOM 2827 C CD    . GLN A 1 414 ? 122.781 128.979 130.221 1.00 43.50  ? 414 GLN A CD    1 
ATOM 2828 O OE1   . GLN A 1 414 ? 122.959 127.784 130.038 1.00 35.32  ? 414 GLN A OE1   1 
ATOM 2829 N NE2   . GLN A 1 414 ? 123.699 129.754 130.785 1.00 41.89  ? 414 GLN A NE2   1 
ATOM 2830 N N     . PRO A 1 415 ? 121.207 126.280 127.983 1.00 37.99  ? 415 PRO A N     1 
ATOM 2831 C CA    . PRO A 1 415 ? 120.507 125.110 128.505 1.00 43.25  ? 415 PRO A CA    1 
ATOM 2832 C C     . PRO A 1 415 ? 120.211 125.270 129.981 1.00 48.62  ? 415 PRO A C     1 
ATOM 2833 O O     . PRO A 1 415 ? 121.102 125.619 130.779 1.00 55.90  ? 415 PRO A O     1 
ATOM 2834 C CB    . PRO A 1 415 ? 121.490 123.961 128.242 1.00 37.47  ? 415 PRO A CB    1 
ATOM 2835 C CG    . PRO A 1 415 ? 122.798 124.596 128.089 1.00 41.49  ? 415 PRO A CG    1 
ATOM 2836 C CD    . PRO A 1 415 ? 122.531 125.917 127.450 1.00 45.58  ? 415 PRO A CD    1 
ATOM 2837 N N     . PRO A 1 416 ? 118.964 125.025 130.394 1.00 51.42  ? 416 PRO A N     1 
ATOM 2838 C CA    . PRO A 1 416 ? 118.524 125.460 131.723 1.00 51.17  ? 416 PRO A CA    1 
ATOM 2839 C C     . PRO A 1 416 ? 119.050 124.572 132.832 1.00 46.55  ? 416 PRO A C     1 
ATOM 2840 O O     . PRO A 1 416 ? 119.090 123.344 132.719 1.00 41.00  ? 416 PRO A O     1 
ATOM 2841 C CB    . PRO A 1 416 ? 116.998 125.378 131.632 1.00 46.17  ? 416 PRO A CB    1 
ATOM 2842 C CG    . PRO A 1 416 ? 116.743 124.318 130.635 1.00 43.67  ? 416 PRO A CG    1 
ATOM 2843 C CD    . PRO A 1 416 ? 117.887 124.343 129.655 1.00 52.93  ? 416 PRO A CD    1 
ATOM 2844 N N     . SER A 1 417 ? 119.466 125.228 133.908 1.00 53.93  ? 417 SER A N     1 
ATOM 2845 C CA    . SER A 1 417 ? 119.958 124.533 135.083 1.00 56.67  ? 417 SER A CA    1 
ATOM 2846 C C     . SER A 1 417 ? 118.801 123.838 135.782 1.00 51.65  ? 417 SER A C     1 
ATOM 2847 O O     . SER A 1 417 ? 117.744 124.437 135.999 1.00 53.44  ? 417 SER A O     1 
ATOM 2848 C CB    . SER A 1 417 ? 120.635 125.527 136.021 1.00 56.23  ? 417 SER A CB    1 
ATOM 2849 O OG    . SER A 1 417 ? 121.972 125.778 135.629 1.00 48.84  ? 417 SER A OG    1 
ATOM 2850 N N     . ILE A 1 418 ? 118.994 122.572 136.122 1.00 44.92  ? 418 ILE A N     1 
ATOM 2851 C CA    . ILE A 1 418 ? 117.945 121.772 136.734 1.00 55.34  ? 418 ILE A CA    1 
ATOM 2852 C C     . ILE A 1 418 ? 118.246 121.609 138.214 1.00 62.70  ? 418 ILE A C     1 
ATOM 2853 O O     . ILE A 1 418 ? 119.399 121.706 138.648 1.00 64.08  ? 418 ILE A O     1 
ATOM 2854 C CB    . ILE A 1 418 ? 117.776 120.417 136.002 1.00 52.37  ? 418 ILE A CB    1 
ATOM 2855 C CG1   . ILE A 1 418 ? 119.107 119.747 135.617 1.00 49.16  ? 418 ILE A CG1   1 
ATOM 2856 C CG2   . ILE A 1 418 ? 116.967 120.599 134.747 1.00 53.31  ? 418 ILE A CG2   1 
ATOM 2857 C CD1   . ILE A 1 418 ? 119.859 119.010 136.699 1.00 47.40  ? 418 ILE A CD1   1 
ATOM 2858 N N     . LEU A 1 419 ? 117.200 121.368 138.994 1.00 55.51  ? 419 LEU A N     1 
ATOM 2859 C CA    . LEU A 1 419 ? 117.336 121.082 140.413 1.00 43.79  ? 419 LEU A CA    1 
ATOM 2860 C C     . LEU A 1 419 ? 117.002 119.618 140.643 1.00 41.38  ? 419 LEU A C     1 
ATOM 2861 O O     . LEU A 1 419 ? 115.991 119.119 140.141 1.00 47.40  ? 419 LEU A O     1 
ATOM 2862 C CB    . LEU A 1 419 ? 116.421 121.974 141.256 1.00 42.86  ? 419 LEU A CB    1 
ATOM 2863 C CG    . LEU A 1 419 ? 116.282 121.620 142.733 1.00 46.02  ? 419 LEU A CG    1 
ATOM 2864 C CD1   . LEU A 1 419 ? 117.607 121.818 143.434 1.00 48.99  ? 419 LEU A CD1   1 
ATOM 2865 C CD2   . LEU A 1 419 ? 115.199 122.460 143.380 1.00 48.78  ? 419 LEU A CD2   1 
ATOM 2866 N N     . TYR A 1 420 ? 117.866 118.931 141.370 1.00 39.60  ? 420 TYR A N     1 
ATOM 2867 C CA    . TYR A 1 420 ? 117.587 117.593 141.855 1.00 37.79  ? 420 TYR A CA    1 
ATOM 2868 C C     . TYR A 1 420 ? 117.493 117.705 143.367 1.00 40.96  ? 420 TYR A C     1 
ATOM 2869 O O     . TYR A 1 420 ? 118.219 118.497 143.974 1.00 46.47  ? 420 TYR A O     1 
ATOM 2870 C CB    . TYR A 1 420 ? 118.690 116.628 141.446 1.00 36.58  ? 420 TYR A CB    1 
ATOM 2871 C CG    . TYR A 1 420 ? 118.735 116.297 139.980 1.00 40.08  ? 420 TYR A CG    1 
ATOM 2872 C CD1   . TYR A 1 420 ? 117.600 116.365 139.192 1.00 45.23  ? 420 TYR A CD1   1 
ATOM 2873 C CD2   . TYR A 1 420 ? 119.928 115.920 139.381 1.00 42.11  ? 420 TYR A CD2   1 
ATOM 2874 C CE1   . TYR A 1 420 ? 117.659 116.058 137.845 1.00 49.51  ? 420 TYR A CE1   1 
ATOM 2875 C CE2   . TYR A 1 420 ? 119.995 115.621 138.045 1.00 45.22  ? 420 TYR A CE2   1 
ATOM 2876 C CZ    . TYR A 1 420 ? 118.856 115.680 137.283 1.00 45.02  ? 420 TYR A CZ    1 
ATOM 2877 O OH    . TYR A 1 420 ? 118.917 115.379 135.948 1.00 41.13  ? 420 TYR A OH    1 
ATOM 2878 N N     . GLY A 1 421 ? 116.606 116.929 143.975 1.00 48.14  ? 421 GLY A N     1 
ATOM 2879 C CA    . GLY A 1 421 ? 116.350 117.091 145.393 1.00 51.74  ? 421 GLY A CA    1 
ATOM 2880 C C     . GLY A 1 421 ? 117.329 116.352 146.277 1.00 49.36  ? 421 GLY A C     1 
ATOM 2881 O O     . GLY A 1 421 ? 118.544 116.521 146.150 1.00 54.38  ? 421 GLY A O     1 
ATOM 2882 N N     . GLY A 1 422 ? 116.808 115.546 147.195 1.00 45.43  ? 422 GLY A N     1 
ATOM 2883 C CA    . GLY A 1 422 ? 117.650 114.720 148.034 1.00 47.88  ? 422 GLY A CA    1 
ATOM 2884 C C     . GLY A 1 422 ? 118.304 115.460 149.181 1.00 49.71  ? 422 GLY A C     1 
ATOM 2885 O O     . GLY A 1 422 ? 117.756 116.442 149.691 1.00 44.31  ? 422 GLY A O     1 
ATOM 2886 N N     . ARG A 1 423 ? 119.480 114.985 149.597 1.00 50.63  ? 423 ARG A N     1 
ATOM 2887 C CA    . ARG A 1 423 ? 120.173 115.570 150.738 1.00 50.07  ? 423 ARG A CA    1 
ATOM 2888 C C     . ARG A 1 423 ? 120.776 116.930 150.418 1.00 45.82  ? 423 ARG A C     1 
ATOM 2889 O O     . ARG A 1 423 ? 120.680 117.852 151.234 1.00 45.57  ? 423 ARG A O     1 
ATOM 2890 C CB    . ARG A 1 423 ? 121.277 114.629 151.218 1.00 53.95  ? 423 ARG A CB    1 
ATOM 2891 C CG    . ARG A 1 423 ? 120.858 113.172 151.343 1.00 49.04  ? 423 ARG A CG    1 
ATOM 2892 C CD    . ARG A 1 423 ? 121.980 112.122 151.615 1.00 47.62  ? 423 ARG A CD    1 
ATOM 2893 N NE    . ARG A 1 423 ? 123.057 112.009 150.628 1.00 53.47  ? 423 ARG A NE    1 
ATOM 2894 C CZ    . ARG A 1 423 ? 124.129 112.788 150.530 1.00 49.91  ? 423 ARG A CZ    1 
ATOM 2895 N NH1   . ARG A 1 423 ? 124.437 113.671 151.466 1.00 46.96  ? 423 ARG A NH1   1 
ATOM 2896 N NH2   . ARG A 1 423 ? 124.943 112.641 149.488 1.00 43.68  ? 423 ARG A NH2   1 
ATOM 2897 N N     . ASN A 1 424 ? 121.392 117.075 149.247 1.00 43.05  ? 424 ASN A N     1 
ATOM 2898 C CA    . ASN A 1 424 ? 122.116 118.290 148.902 1.00 47.04  ? 424 ASN A CA    1 
ATOM 2899 C C     . ASN A 1 424 ? 121.226 119.397 148.358 1.00 42.67  ? 424 ASN A C     1 
ATOM 2900 O O     . ASN A 1 424 ? 121.398 120.553 148.764 1.00 46.74  ? 424 ASN A O     1 
ATOM 2901 C CB    . ASN A 1 424 ? 123.212 117.973 147.878 1.00 46.20  ? 424 ASN A CB    1 
ATOM 2902 C CG    . ASN A 1 424 ? 122.741 117.022 146.797 1.00 44.77  ? 424 ASN A CG    1 
ATOM 2903 O OD1   . ASN A 1 424 ? 121.785 117.307 146.076 1.00 44.01  ? 424 ASN A OD1   1 
ATOM 2904 N ND2   . ASN A 1 424 ? 123.406 115.879 146.684 1.00 43.97  ? 424 ASN A ND2   1 
ATOM 2905 N N     . LYS A 1 425 ? 120.282 119.049 147.473 1.00 38.55  ? 425 LYS A N     1 
ATOM 2906 C CA    . LYS A 1 425 ? 119.396 119.980 146.759 1.00 37.58  ? 425 LYS A CA    1 
ATOM 2907 C C     . LYS A 1 425 ? 120.190 121.052 146.011 1.00 43.68  ? 425 LYS A C     1 
ATOM 2908 O O     . LYS A 1 425 ? 119.875 122.243 146.049 1.00 49.09  ? 425 LYS A O     1 
ATOM 2909 C CB    . LYS A 1 425 ? 118.358 120.607 147.697 1.00 37.35  ? 425 LYS A CB    1 
ATOM 2910 C CG    . LYS A 1 425 ? 117.030 120.908 147.025 1.00 36.86  ? 425 LYS A CG    1 
ATOM 2911 C CD    . LYS A 1 425 ? 115.983 121.362 148.017 1.00 38.75  ? 425 LYS A CD    1 
ATOM 2912 C CE    . LYS A 1 425 ? 114.630 120.753 147.693 1.00 44.48  ? 425 LYS A CE    1 
ATOM 2913 N NZ    . LYS A 1 425 ? 114.020 121.380 146.487 1.00 42.04  ? 425 LYS A NZ    1 
ATOM 2914 N N     . ALA A 1 426 ? 121.246 120.613 145.328 1.00 49.77  ? 426 ALA A N     1 
ATOM 2915 C CA    . ALA A 1 426 ? 122.080 121.529 144.569 1.00 50.59  ? 426 ALA A CA    1 
ATOM 2916 C C     . ALA A 1 426 ? 121.764 121.426 143.078 1.00 46.73  ? 426 ALA A C     1 
ATOM 2917 O O     . ALA A 1 426 ? 120.896 120.666 142.643 1.00 41.89  ? 426 ALA A O     1 
ATOM 2918 C CB    . ALA A 1 426 ? 123.559 121.268 144.849 1.00 50.37  ? 426 ALA A CB    1 
ATOM 2919 N N     . ILE A 1 427 ? 122.499 122.196 142.282 1.00 59.12  ? 427 ILE A N     1 
ATOM 2920 C CA    . ILE A 1 427 ? 122.132 122.501 140.907 1.00 53.85  ? 427 ILE A CA    1 
ATOM 2921 C C     . ILE A 1 427 ? 123.137 121.858 139.962 1.00 57.59  ? 427 ILE A C     1 
ATOM 2922 O O     . ILE A 1 427 ? 124.343 121.839 140.228 1.00 64.60  ? 427 ILE A O     1 
ATOM 2923 C CB    . ILE A 1 427 ? 122.072 124.032 140.675 1.00 56.45  ? 427 ILE A CB    1 
ATOM 2924 C CG1   . ILE A 1 427 ? 121.477 124.763 141.885 1.00 62.41  ? 427 ILE A CG1   1 
ATOM 2925 C CG2   . ILE A 1 427 ? 121.277 124.358 139.445 1.00 51.99  ? 427 ILE A CG2   1 
ATOM 2926 C CD1   . ILE A 1 427 ? 120.006 124.470 142.148 1.00 65.41  ? 427 ILE A CD1   1 
ATOM 2927 N N     . ALA A 1 428 ? 122.633 121.320 138.853 1.00 50.41  ? 428 ALA A N     1 
ATOM 2928 C CA    . ALA A 1 428 ? 123.485 120.838 137.771 1.00 49.25  ? 428 ALA A CA    1 
ATOM 2929 C C     . ALA A 1 428 ? 123.043 121.502 136.477 1.00 50.00  ? 428 ALA A C     1 
ATOM 2930 O O     . ALA A 1 428 ? 121.842 121.611 136.211 1.00 47.35  ? 428 ALA A O     1 
ATOM 2931 C CB    . ALA A 1 428 ? 123.432 119.313 137.649 1.00 45.73  ? 428 ALA A CB    1 
ATOM 2932 N N     . THR A 1 429 ? 124.015 121.962 135.679 1.00 49.80  ? 429 THR A N     1 
ATOM 2933 C CA    . THR A 1 429 ? 123.745 122.661 134.426 1.00 50.29  ? 429 THR A CA    1 
ATOM 2934 C C     . THR A 1 429 ? 124.105 121.761 133.243 1.00 52.73  ? 429 THR A C     1 
ATOM 2935 O O     . THR A 1 429 ? 124.942 120.859 133.392 1.00 56.49  ? 429 THR A O     1 
ATOM 2936 C CB    . THR A 1 429 ? 124.517 123.988 134.376 1.00 44.74  ? 429 THR A CB    1 
ATOM 2937 O OG1   . THR A 1 429 ? 124.068 124.788 133.275 1.00 38.24  ? 429 THR A OG1   1 
ATOM 2938 C CG2   . THR A 1 429 ? 126.027 123.785 134.290 1.00 45.73  ? 429 THR A CG2   1 
ATOM 2939 N N     . PRO A 1 430 ? 123.450 121.903 132.089 1.00 50.56  ? 430 PRO A N     1 
ATOM 2940 C CA    . PRO A 1 430 ? 123.791 121.042 130.952 1.00 45.97  ? 430 PRO A CA    1 
ATOM 2941 C C     . PRO A 1 430 ? 124.913 121.632 130.113 1.00 48.34  ? 430 PRO A C     1 
ATOM 2942 O O     . PRO A 1 430 ? 124.970 122.840 129.873 1.00 42.49  ? 430 PRO A O     1 
ATOM 2943 C CB    . PRO A 1 430 ? 122.483 120.972 130.153 1.00 38.50  ? 430 PRO A CB    1 
ATOM 2944 C CG    . PRO A 1 430 ? 121.427 121.548 131.053 1.00 33.90  ? 430 PRO A CG    1 
ATOM 2945 C CD    . PRO A 1 430 ? 122.143 122.545 131.886 1.00 45.25  ? 430 PRO A CD    1 
ATOM 2946 N N     . VAL A 1 431 ? 125.812 120.758 129.666 1.00 50.87  ? 431 VAL A N     1 
ATOM 2947 C CA    . VAL A 1 431 ? 126.871 121.141 128.732 1.00 50.79  ? 431 VAL A CA    1 
ATOM 2948 C C     . VAL A 1 431 ? 126.346 120.936 127.305 1.00 54.55  ? 431 VAL A C     1 
ATOM 2949 O O     . VAL A 1 431 ? 126.563 119.916 126.640 1.00 54.90  ? 431 VAL A O     1 
ATOM 2950 C CB    . VAL A 1 431 ? 128.215 120.471 129.079 1.00 54.86  ? 431 VAL A CB    1 
ATOM 2951 C CG1   . VAL A 1 431 ? 128.495 120.742 130.532 1.00 50.48  ? 431 VAL A CG1   1 
ATOM 2952 C CG2   . VAL A 1 431 ? 128.192 118.919 129.092 1.00 50.91  ? 431 VAL A CG2   1 
ATOM 2953 N N     . GLN A 1 432 ? 125.627 121.964 126.837 1.00 41.65  ? 432 GLN A N     1 
ATOM 2954 C CA    . GLN A 1 432 ? 124.974 122.044 125.523 1.00 38.09  ? 432 GLN A CA    1 
ATOM 2955 C C     . GLN A 1 432 ? 124.012 120.875 125.300 1.00 42.90  ? 432 GLN A C     1 
ATOM 2956 O O     . GLN A 1 432 ? 124.186 120.045 124.408 1.00 45.15  ? 432 GLN A O     1 
ATOM 2957 C CB    . GLN A 1 432 ? 126.002 122.144 124.388 1.00 44.70  ? 432 GLN A CB    1 
ATOM 2958 C CG    . GLN A 1 432 ? 126.643 123.513 124.242 1.00 37.57  ? 432 GLN A CG    1 
ATOM 2959 C CD    . GLN A 1 432 ? 125.626 124.619 124.070 1.00 42.99  ? 432 GLN A CD    1 
ATOM 2960 O OE1   . GLN A 1 432 ? 125.637 125.607 124.803 1.00 49.49  ? 432 GLN A OE1   1 
ATOM 2961 N NE2   . GLN A 1 432 ? 124.744 124.465 123.091 1.00 40.21  ? 432 GLN A NE2   1 
ATOM 2962 N N     . GLY A 1 433 ? 122.998 120.812 126.158 1.00 40.18  ? 433 GLY A N     1 
ATOM 2963 C CA    . GLY A 1 433 ? 121.925 119.853 126.021 1.00 40.89  ? 433 GLY A CA    1 
ATOM 2964 C C     . GLY A 1 433 ? 122.116 118.532 126.736 1.00 29.74  ? 433 GLY A C     1 
ATOM 2965 O O     . GLY A 1 433 ? 121.159 117.756 126.825 1.00 23.83  ? 433 GLY A O     1 
ATOM 2966 N N     . VAL A 1 434 ? 123.312 118.244 127.248 1.00 33.94  ? 434 VAL A N     1 
ATOM 2967 C CA    . VAL A 1 434 ? 123.614 116.979 127.911 1.00 41.07  ? 434 VAL A CA    1 
ATOM 2968 C C     . VAL A 1 434 ? 124.114 117.281 129.318 1.00 46.44  ? 434 VAL A C     1 
ATOM 2969 O O     . VAL A 1 434 ? 124.941 118.178 129.509 1.00 43.96  ? 434 VAL A O     1 
ATOM 2970 C CB    . VAL A 1 434 ? 124.676 116.161 127.141 1.00 38.57  ? 434 VAL A CB    1 
ATOM 2971 C CG1   . VAL A 1 434 ? 124.839 114.767 127.736 1.00 37.69  ? 434 VAL A CG1   1 
ATOM 2972 C CG2   . VAL A 1 434 ? 124.363 116.088 125.668 1.00 41.12  ? 434 VAL A CG2   1 
ATOM 2973 N N     . TRP A 1 435 ? 123.607 116.541 130.302 1.00 45.56  ? 435 TRP A N     1 
ATOM 2974 C CA    . TRP A 1 435 ? 124.157 116.591 131.651 1.00 40.02  ? 435 TRP A CA    1 
ATOM 2975 C C     . TRP A 1 435 ? 124.001 115.232 132.306 1.00 41.36  ? 435 TRP A C     1 
ATOM 2976 O O     . TRP A 1 435 ? 123.057 114.496 132.029 1.00 40.18  ? 435 TRP A O     1 
ATOM 2977 C CB    . TRP A 1 435 ? 123.486 117.681 132.493 1.00 40.43  ? 435 TRP A CB    1 
ATOM 2978 C CG    . TRP A 1 435 ? 122.171 117.297 133.115 1.00 44.98  ? 435 TRP A CG    1 
ATOM 2979 C CD1   . TRP A 1 435 ? 121.954 116.704 134.333 1.00 39.88  ? 435 TRP A CD1   1 
ATOM 2980 C CD2   . TRP A 1 435 ? 120.885 117.495 132.538 1.00 37.96  ? 435 TRP A CD2   1 
ATOM 2981 N NE1   . TRP A 1 435 ? 120.612 116.516 134.532 1.00 36.05  ? 435 TRP A NE1   1 
ATOM 2982 C CE2   . TRP A 1 435 ? 119.934 117.004 133.448 1.00 32.09  ? 435 TRP A CE2   1 
ATOM 2983 C CE3   . TRP A 1 435 ? 120.445 118.048 131.339 1.00 39.17  ? 435 TRP A CE3   1 
ATOM 2984 C CZ2   . TRP A 1 435 ? 118.574 117.050 133.192 1.00 30.51  ? 435 TRP A CZ2   1 
ATOM 2985 C CZ3   . TRP A 1 435 ? 119.106 118.088 131.091 1.00 32.30  ? 435 TRP A CZ3   1 
ATOM 2986 C CH2   . TRP A 1 435 ? 118.183 117.601 132.011 1.00 19.56  ? 435 TRP A CH2   1 
ATOM 2987 N N     . ASP A 1 436 ? 124.897 114.940 133.239 1.00 45.61  ? 436 ASP A N     1 
ATOM 2988 C CA    . ASP A 1 436 ? 124.772 113.732 134.034 1.00 44.96  ? 436 ASP A CA    1 
ATOM 2989 C C     . ASP A 1 436 ? 124.533 114.124 135.482 1.00 46.94  ? 436 ASP A C     1 
ATOM 2990 O O     . ASP A 1 436 ? 124.953 115.195 135.927 1.00 48.87  ? 436 ASP A O     1 
ATOM 2991 C CB    . ASP A 1 436 ? 126.010 112.840 133.912 1.00 46.71  ? 436 ASP A CB    1 
ATOM 2992 C CG    . ASP A 1 436 ? 125.927 111.889 132.735 1.00 46.96  ? 436 ASP A CG    1 
ATOM 2993 O OD1   . ASP A 1 436 ? 125.449 112.314 131.662 1.00 40.64  ? 436 ASP A OD1   1 
ATOM 2994 O OD2   . ASP A 1 436 ? 126.328 110.716 132.885 1.00 53.80  ? 436 ASP A OD2   1 
ATOM 2995 N N     . MET A 1 437 ? 123.821 113.252 136.202 1.00 50.22  ? 437 MET A N     1 
ATOM 2996 C CA    . MET A 1 437 ? 123.538 113.499 137.612 1.00 52.12  ? 437 MET A CA    1 
ATOM 2997 C C     . MET A 1 437 ? 124.812 113.426 138.446 1.00 55.88  ? 437 MET A C     1 
ATOM 2998 O O     . MET A 1 437 ? 125.098 114.340 139.230 1.00 55.03  ? 437 MET A O     1 
ATOM 2999 C CB    . MET A 1 437 ? 122.502 112.497 138.121 1.00 52.09  ? 437 MET A CB    1 
ATOM 3000 C CG    . MET A 1 437 ? 121.340 112.227 137.170 1.00 51.27  ? 437 MET A CG    1 
ATOM 3001 S SD    . MET A 1 437 ? 119.735 112.122 137.998 1.00 60.30  ? 437 MET A SD    1 
ATOM 3002 C CE    . MET A 1 437 ? 119.817 110.494 138.732 1.00 45.30  ? 437 MET A CE    1 
ATOM 3003 N N     . ARG A 1 438 ? 125.591 112.346 138.266 1.00 54.49  ? 438 ARG A N     1 
ATOM 3004 C CA    . ARG A 1 438 ? 126.905 112.119 138.890 1.00 54.02  ? 438 ARG A CA    1 
ATOM 3005 C C     . ARG A 1 438 ? 126.831 112.156 140.419 1.00 57.12  ? 438 ARG A C     1 
ATOM 3006 O O     . ARG A 1 438 ? 127.362 113.065 141.067 1.00 52.39  ? 438 ARG A O     1 
ATOM 3007 C CB    . ARG A 1 438 ? 127.957 113.103 138.358 1.00 52.08  ? 438 ARG A CB    1 
ATOM 3008 C CG    . ARG A 1 438 ? 128.298 112.935 136.884 1.00 52.32  ? 438 ARG A CG    1 
ATOM 3009 C CD    . ARG A 1 438 ? 128.781 111.522 136.583 1.00 59.81  ? 438 ARG A CD    1 
ATOM 3010 N NE    . ARG A 1 438 ? 127.796 110.718 135.871 1.00 62.29  ? 438 ARG A NE    1 
ATOM 3011 C CZ    . ARG A 1 438 ? 127.937 109.426 135.608 1.00 53.32  ? 438 ARG A CZ    1 
ATOM 3012 N NH1   . ARG A 1 438 ? 129.012 108.756 135.990 1.00 51.51  ? 438 ARG A NH1   1 
ATOM 3013 N NH2   . ARG A 1 438 ? 126.977 108.790 134.943 1.00 44.70  ? 438 ARG A NH2   1 
ATOM 3014 N N     . ASN A 1 439 ? 126.131 111.150 140.968 1.00 52.41  ? 439 ASN A N     1 
ATOM 3015 C CA    . ASN A 1 439 ? 125.913 110.958 142.411 1.00 56.29  ? 439 ASN A CA    1 
ATOM 3016 C C     . ASN A 1 439 ? 125.210 112.157 143.046 1.00 53.92  ? 439 ASN A C     1 
ATOM 3017 O O     . ASN A 1 439 ? 125.618 112.658 144.095 1.00 55.28  ? 439 ASN A O     1 
ATOM 3018 C CB    . ASN A 1 439 ? 127.215 110.634 143.152 1.00 57.01  ? 439 ASN A CB    1 
ATOM 3019 C CG    . ASN A 1 439 ? 127.843 109.344 142.683 1.00 54.18  ? 439 ASN A CG    1 
ATOM 3020 O OD1   . ASN A 1 439 ? 127.193 108.521 142.040 1.00 50.90  ? 439 ASN A OD1   1 
ATOM 3021 N ND2   . ASN A 1 439 ? 129.116 109.155 143.008 1.00 51.79  ? 439 ASN A ND2   1 
ATOM 3022 N N     . LYS A 1 440 ? 124.153 112.627 142.395 1.00 45.78  ? 440 LYS A N     1 
ATOM 3023 C CA    . LYS A 1 440 ? 123.307 113.692 142.917 1.00 45.18  ? 440 LYS A CA    1 
ATOM 3024 C C     . LYS A 1 440 ? 121.896 113.132 143.073 1.00 47.18  ? 440 LYS A C     1 
ATOM 3025 O O     . LYS A 1 440 ? 121.328 112.589 142.120 1.00 52.04  ? 440 LYS A O     1 
ATOM 3026 C CB    . LYS A 1 440 ? 123.345 114.910 141.998 1.00 44.03  ? 440 LYS A CB    1 
ATOM 3027 C CG    . LYS A 1 440 ? 122.170 115.832 142.155 1.00 47.09  ? 440 LYS A CG    1 
ATOM 3028 C CD    . LYS A 1 440 ? 122.438 117.217 141.595 1.00 51.41  ? 440 LYS A CD    1 
ATOM 3029 C CE    . LYS A 1 440 ? 123.384 117.989 142.466 1.00 45.58  ? 440 LYS A CE    1 
ATOM 3030 N NZ    . LYS A 1 440 ? 122.757 118.156 143.796 1.00 38.97  ? 440 LYS A NZ    1 
ATOM 3031 N N     . GLN A 1 441 ? 121.339 113.258 144.276 1.00 52.32  ? 441 GLN A N     1 
ATOM 3032 C CA    . GLN A 1 441 ? 120.078 112.603 144.607 1.00 51.02  ? 441 GLN A CA    1 
ATOM 3033 C C     . GLN A 1 441 ? 118.890 113.370 144.033 1.00 48.70  ? 441 GLN A C     1 
ATOM 3034 O O     . GLN A 1 441 ? 118.877 114.600 144.003 1.00 42.25  ? 441 GLN A O     1 
ATOM 3035 C CB    . GLN A 1 441 ? 119.938 112.468 146.126 1.00 45.21  ? 441 GLN A CB    1 
ATOM 3036 C CG    . GLN A 1 441 ? 120.866 111.433 146.766 1.00 47.60  ? 441 GLN A CG    1 
ATOM 3037 C CD    . GLN A 1 441 ? 122.270 111.954 147.031 1.00 54.79  ? 441 GLN A CD    1 
ATOM 3038 O OE1   . GLN A 1 441 ? 122.471 113.144 147.275 1.00 50.26  ? 441 GLN A OE1   1 
ATOM 3039 N NE2   . GLN A 1 441 ? 123.249 111.059 146.981 1.00 54.86  ? 441 GLN A NE2   1 
ATOM 3040 N N     . PHE A 1 442 ? 117.872 112.631 143.592 1.00 53.38  ? 442 PHE A N     1 
ATOM 3041 C CA    . PHE A 1 442 ? 116.730 113.252 142.931 1.00 48.39  ? 442 PHE A CA    1 
ATOM 3042 C C     . PHE A 1 442 ? 115.713 113.748 143.953 1.00 46.68  ? 442 PHE A C     1 
ATOM 3043 O O     . PHE A 1 442 ? 115.961 113.784 145.160 1.00 51.16  ? 442 PHE A O     1 
ATOM 3044 C CB    . PHE A 1 442 ? 116.064 112.304 141.935 1.00 45.36  ? 442 PHE A CB    1 
ATOM 3045 C CG    . PHE A 1 442 ? 116.057 110.856 142.341 1.00 41.05  ? 442 PHE A CG    1 
ATOM 3046 C CD1   . PHE A 1 442 ? 115.299 110.423 143.414 1.00 43.59  ? 442 PHE A CD1   1 
ATOM 3047 C CD2   . PHE A 1 442 ? 116.731 109.914 141.574 1.00 40.08  ? 442 PHE A CD2   1 
ATOM 3048 C CE1   . PHE A 1 442 ? 115.274 109.096 143.758 1.00 43.44  ? 442 PHE A CE1   1 
ATOM 3049 C CE2   . PHE A 1 442 ? 116.689 108.583 141.899 1.00 42.56  ? 442 PHE A CE2   1 
ATOM 3050 C CZ    . PHE A 1 442 ? 115.972 108.174 143.000 1.00 48.49  ? 442 PHE A CZ    1 
ATOM 3051 N N     . HIS A 1 443 ? 114.525 114.101 143.461 1.00 29.95  ? 443 HIS A N     1 
ATOM 3052 C CA    . HIS A 1 443 ? 113.561 114.844 144.263 1.00 37.85  ? 443 HIS A CA    1 
ATOM 3053 C C     . HIS A 1 443 ? 112.807 113.948 145.237 1.00 43.16  ? 443 HIS A C     1 
ATOM 3054 O O     . HIS A 1 443 ? 112.951 114.083 146.456 1.00 47.73  ? 443 HIS A O     1 
ATOM 3055 C CB    . HIS A 1 443 ? 112.592 115.574 143.338 1.00 38.33  ? 443 HIS A CB    1 
ATOM 3056 C CG    . HIS A 1 443 ? 112.112 116.885 143.873 1.00 42.47  ? 443 HIS A CG    1 
ATOM 3057 N ND1   . HIS A 1 443 ? 112.958 117.940 144.133 1.00 42.54  ? 443 HIS A ND1   1 
ATOM 3058 C CD2   . HIS A 1 443 ? 110.866 117.317 144.176 1.00 43.23  ? 443 HIS A CD2   1 
ATOM 3059 C CE1   . HIS A 1 443 ? 112.256 118.960 144.593 1.00 45.63  ? 443 HIS A CE1   1 
ATOM 3060 N NE2   . HIS A 1 443 ? 110.983 118.610 144.623 1.00 51.16  ? 443 HIS A NE2   1 
ATOM 3061 N N     . THR A 1 444 ? 112.000 113.021 144.724 1.00 43.93  ? 444 THR A N     1 
ATOM 3062 C CA    . THR A 1 444 ? 111.184 112.147 145.567 1.00 40.54  ? 444 THR A CA    1 
ATOM 3063 C C     . THR A 1 444 ? 111.555 110.698 145.272 1.00 43.10  ? 444 THR A C     1 
ATOM 3064 O O     . THR A 1 444 ? 111.077 110.118 144.294 1.00 45.74  ? 444 THR A O     1 
ATOM 3065 C CB    . THR A 1 444 ? 109.688 112.365 145.343 1.00 39.50  ? 444 THR A CB    1 
ATOM 3066 O OG1   . THR A 1 444 ? 109.335 111.946 144.022 1.00 39.59  ? 444 THR A OG1   1 
ATOM 3067 C CG2   . THR A 1 444 ? 109.303 113.824 145.525 1.00 42.94  ? 444 THR A CG2   1 
ATOM 3068 N N     . GLY A 1 445 ? 112.401 110.115 146.112 1.00 45.07  ? 445 GLY A N     1 
ATOM 3069 C CA    . GLY A 1 445 ? 112.563 108.678 146.094 1.00 43.58  ? 445 GLY A CA    1 
ATOM 3070 C C     . GLY A 1 445 ? 111.336 107.990 146.660 1.00 50.41  ? 445 GLY A C     1 
ATOM 3071 O O     . GLY A 1 445 ? 110.568 108.568 147.429 1.00 53.38  ? 445 GLY A O     1 
ATOM 3072 N N     . ILE A 1 446 ? 111.145 106.734 146.271 1.00 43.02  ? 446 ILE A N     1 
ATOM 3073 C CA    . ILE A 1 446 ? 109.948 105.978 146.617 1.00 40.53  ? 446 ILE A CA    1 
ATOM 3074 C C     . ILE A 1 446 ? 110.360 104.758 147.423 1.00 43.78  ? 446 ILE A C     1 
ATOM 3075 O O     . ILE A 1 446 ? 111.271 104.021 147.026 1.00 45.34  ? 446 ILE A O     1 
ATOM 3076 C CB    . ILE A 1 446 ? 109.156 105.592 145.356 1.00 41.21  ? 446 ILE A CB    1 
ATOM 3077 C CG1   . ILE A 1 446 ? 108.504 106.838 144.774 1.00 37.47  ? 446 ILE A CG1   1 
ATOM 3078 C CG2   . ILE A 1 446 ? 108.081 104.568 145.657 1.00 47.74  ? 446 ILE A CG2   1 
ATOM 3079 C CD1   . ILE A 1 446 ? 108.920 107.113 143.387 1.00 34.46  ? 446 ILE A CD1   1 
ATOM 3080 N N     . GLU A 1 447 ? 109.700 104.559 148.563 1.00 42.60  ? 447 GLU A N     1 
ATOM 3081 C CA    . GLU A 1 447 ? 109.951 103.412 149.422 1.00 44.79  ? 447 GLU A CA    1 
ATOM 3082 C C     . GLU A 1 447 ? 109.462 102.134 148.754 1.00 42.09  ? 447 GLU A C     1 
ATOM 3083 O O     . GLU A 1 447 ? 108.267 101.823 148.788 1.00 43.75  ? 447 GLU A O     1 
ATOM 3084 C CB    . GLU A 1 447 ? 109.272 103.608 150.781 1.00 42.32  ? 447 GLU A CB    1 
ATOM 3085 C CG    . GLU A 1 447 ? 107.998 104.457 150.747 1.00 40.42  ? 447 GLU A CG    1 
ATOM 3086 C CD    . GLU A 1 447 ? 108.237 105.902 151.144 1.00 40.12  ? 447 GLU A CD    1 
ATOM 3087 O OE1   . GLU A 1 447 ? 109.004 106.593 150.442 1.00 40.26  ? 447 GLU A OE1   1 
ATOM 3088 O OE2   . GLU A 1 447 ? 107.654 106.347 152.155 1.00 34.84  ? 447 GLU A OE2   1 
ATOM 3089 N N     . ILE A 1 448 ? 110.370 101.401 148.117 1.00 27.91  ? 448 ILE A N     1 
ATOM 3090 C CA    . ILE A 1 448 ? 110.030 100.147 147.456 1.00 26.73  ? 448 ILE A CA    1 
ATOM 3091 C C     . ILE A 1 448 ? 110.242 99.021  148.461 1.00 31.22  ? 448 ILE A C     1 
ATOM 3092 O O     . ILE A 1 448 ? 111.376 98.732  148.852 1.00 34.77  ? 448 ILE A O     1 
ATOM 3093 C CB    . ILE A 1 448 ? 110.866 99.937  146.191 1.00 25.16  ? 448 ILE A CB    1 
ATOM 3094 C CG1   . ILE A 1 448 ? 110.580 101.063 145.183 1.00 28.02  ? 448 ILE A CG1   1 
ATOM 3095 C CG2   . ILE A 1 448 ? 110.605 98.541  145.628 1.00 36.55  ? 448 ILE A CG2   1 
ATOM 3096 C CD1   . ILE A 1 448 ? 110.775 100.714 143.712 1.00 26.89  ? 448 ILE A CD1   1 
ATOM 3097 N N     . LYS A 1 449 ? 109.149 98.387  148.888 1.00 36.11  ? 449 LYS A N     1 
ATOM 3098 C CA    . LYS A 1 449 ? 109.214 97.380  149.944 1.00 35.88  ? 449 LYS A CA    1 
ATOM 3099 C C     . LYS A 1 449 ? 109.167 95.955  149.392 1.00 39.41  ? 449 LYS A C     1 
ATOM 3100 O O     . LYS A 1 449 ? 110.103 95.174  149.591 1.00 40.05  ? 449 LYS A O     1 
ATOM 3101 C CB    . LYS A 1 449 ? 108.075 97.603  150.947 1.00 41.90  ? 449 LYS A CB    1 
ATOM 3102 C CG    . LYS A 1 449 ? 107.865 99.054  151.352 1.00 42.07  ? 449 LYS A CG    1 
ATOM 3103 C CD    . LYS A 1 449 ? 106.542 99.589  150.825 1.00 41.60  ? 449 LYS A CD    1 
ATOM 3104 C CE    . LYS A 1 449 ? 106.287 101.010 151.304 1.00 41.76  ? 449 LYS A CE    1 
ATOM 3105 N NZ    . LYS A 1 449 ? 105.012 101.557 150.767 1.00 40.87  ? 449 LYS A NZ    1 
ATOM 3106 N N     . VAL A 1 450 ? 108.087 95.603  148.698 1.00 36.69  ? 450 VAL A N     1 
ATOM 3107 C CA    . VAL A 1 450 ? 107.938 94.284  148.093 1.00 33.64  ? 450 VAL A CA    1 
ATOM 3108 C C     . VAL A 1 450 ? 107.715 94.448  146.594 1.00 38.59  ? 450 VAL A C     1 
ATOM 3109 O O     . VAL A 1 450 ? 106.970 95.332  146.153 1.00 35.02  ? 450 VAL A O     1 
ATOM 3110 C CB    . VAL A 1 450 ? 106.814 93.451  148.750 1.00 33.35  ? 450 VAL A CB    1 
ATOM 3111 C CG1   . VAL A 1 450 ? 107.198 93.086  150.171 1.00 39.14  ? 450 VAL A CG1   1 
ATOM 3112 C CG2   . VAL A 1 450 ? 105.477 94.198  148.776 1.00 35.18  ? 450 VAL A CG2   1 
ATOM 3113 N N     . TRP A 1 451 ? 108.414 93.630  145.815 1.00 44.93  ? 451 TRP A N     1 
ATOM 3114 C CA    . TRP A 1 451 ? 108.355 93.669  144.363 1.00 44.65  ? 451 TRP A CA    1 
ATOM 3115 C C     . TRP A 1 451 ? 108.800 92.303  143.857 1.00 43.33  ? 451 TRP A C     1 
ATOM 3116 O O     . TRP A 1 451 ? 109.327 91.490  144.618 1.00 42.10  ? 451 TRP A O     1 
ATOM 3117 C CB    . TRP A 1 451 ? 109.202 94.819  143.782 1.00 34.34  ? 451 TRP A CB    1 
ATOM 3118 C CG    . TRP A 1 451 ? 110.691 94.717  143.948 1.00 35.69  ? 451 TRP A CG    1 
ATOM 3119 C CD1   . TRP A 1 451 ? 111.382 94.248  145.028 1.00 37.57  ? 451 TRP A CD1   1 
ATOM 3120 C CD2   . TRP A 1 451 ? 111.671 95.097  142.983 1.00 36.86  ? 451 TRP A CD2   1 
ATOM 3121 N NE1   . TRP A 1 451 ? 112.730 94.314  144.793 1.00 44.41  ? 451 TRP A NE1   1 
ATOM 3122 C CE2   . TRP A 1 451 ? 112.933 94.830  143.541 1.00 42.63  ? 451 TRP A CE2   1 
ATOM 3123 C CE3   . TRP A 1 451 ? 111.601 95.633  141.697 1.00 35.06  ? 451 TRP A CE3   1 
ATOM 3124 C CZ2   . TRP A 1 451 ? 114.117 95.084  142.858 1.00 37.56  ? 451 TRP A CZ2   1 
ATOM 3125 C CZ3   . TRP A 1 451 ? 112.773 95.887  141.023 1.00 33.89  ? 451 TRP A CZ3   1 
ATOM 3126 C CH2   . TRP A 1 451 ? 114.015 95.611  141.601 1.00 31.25  ? 451 TRP A CH2   1 
ATOM 3127 N N     . ALA A 1 452 ? 108.555 92.035  142.573 1.00 48.35  ? 452 ALA A N     1 
ATOM 3128 C CA    . ALA A 1 452 ? 108.736 90.690  142.043 1.00 49.79  ? 452 ALA A CA    1 
ATOM 3129 C C     . ALA A 1 452 ? 109.404 90.697  140.673 1.00 38.64  ? 452 ALA A C     1 
ATOM 3130 O O     . ALA A 1 452 ? 109.430 91.710  139.972 1.00 22.67  ? 452 ALA A O     1 
ATOM 3131 C CB    . ALA A 1 452 ? 107.402 89.956  141.952 1.00 52.73  ? 452 ALA A CB    1 
ATOM 3132 N N     . ILE A 1 453 ? 109.950 89.541  140.310 1.00 49.52  ? 453 ILE A N     1 
ATOM 3133 C CA    . ILE A 1 453 ? 110.596 89.314  139.023 1.00 50.97  ? 453 ILE A CA    1 
ATOM 3134 C C     . ILE A 1 453 ? 109.841 88.180  138.345 1.00 52.22  ? 453 ILE A C     1 
ATOM 3135 O O     . ILE A 1 453 ? 109.695 87.095  138.920 1.00 52.24  ? 453 ILE A O     1 
ATOM 3136 C CB    . ILE A 1 453 ? 112.086 88.975  139.183 1.00 57.07  ? 453 ILE A CB    1 
ATOM 3137 C CG1   . ILE A 1 453 ? 112.874 90.204  139.641 1.00 53.90  ? 453 ILE A CG1   1 
ATOM 3138 C CG2   . ILE A 1 453 ? 112.666 88.414  137.891 1.00 50.71  ? 453 ILE A CG2   1 
ATOM 3139 C CD1   . ILE A 1 453 ? 114.333 89.918  139.924 1.00 53.29  ? 453 ILE A CD1   1 
ATOM 3140 N N     . ALA A 1 454 ? 109.350 88.417  137.134 1.00 31.07  ? 454 ALA A N     1 
ATOM 3141 C CA    . ALA A 1 454 ? 108.606 87.412  136.380 1.00 33.36  ? 454 ALA A CA    1 
ATOM 3142 C C     . ALA A 1 454 ? 109.224 87.315  134.989 1.00 35.58  ? 454 ALA A C     1 
ATOM 3143 O O     . ALA A 1 454 ? 108.710 87.898  134.038 1.00 29.12  ? 454 ALA A O     1 
ATOM 3144 C CB    . ALA A 1 454 ? 107.126 87.782  136.306 1.00 26.99  ? 454 ALA A CB    1 
ATOM 3145 N N     . CYS A 1 455 ? 110.306 86.544  134.861 1.00 49.93  ? 455 CYS A N     1 
ATOM 3146 C CA    . CYS A 1 455 ? 111.038 86.495  133.598 1.00 42.62  ? 455 CYS A CA    1 
ATOM 3147 C C     . CYS A 1 455 ? 110.259 85.669  132.582 1.00 39.14  ? 455 CYS A C     1 
ATOM 3148 O O     . CYS A 1 455 ? 110.064 84.464  132.766 1.00 41.28  ? 455 CYS A O     1 
ATOM 3149 C CB    . CYS A 1 455 ? 112.438 85.915  133.774 1.00 38.92  ? 455 CYS A CB    1 
ATOM 3150 S SG    . CYS A 1 455 ? 113.142 85.486  132.168 1.00 37.32  ? 455 CYS A SG    1 
ATOM 3151 N N     . PHE A 1 456 ? 109.807 86.324  131.516 1.00 30.87  ? 456 PHE A N     1 
ATOM 3152 C CA    . PHE A 1 456 ? 109.033 85.677  130.465 1.00 35.33  ? 456 PHE A CA    1 
ATOM 3153 C C     . PHE A 1 456 ? 109.876 85.413  129.228 1.00 44.72  ? 456 PHE A C     1 
ATOM 3154 O O     . PHE A 1 456 ? 109.332 85.119  128.161 1.00 47.65  ? 456 PHE A O     1 
ATOM 3155 C CB    . PHE A 1 456 ? 107.806 86.523  130.120 1.00 40.83  ? 456 PHE A CB    1 
ATOM 3156 C CG    . PHE A 1 456 ? 106.592 86.217  130.970 1.00 44.85  ? 456 PHE A CG    1 
ATOM 3157 C CD1   . PHE A 1 456 ? 106.706 85.489  132.147 1.00 44.22  ? 456 PHE A CD1   1 
ATOM 3158 C CD2   . PHE A 1 456 ? 105.345 86.698  130.613 1.00 42.40  ? 456 PHE A CD2   1 
ATOM 3159 C CE1   . PHE A 1 456 ? 105.591 85.221  132.931 1.00 41.78  ? 456 PHE A CE1   1 
ATOM 3160 C CE2   . PHE A 1 456 ? 104.236 86.434  131.392 1.00 42.51  ? 456 PHE A CE2   1 
ATOM 3161 C CZ    . PHE A 1 456 ? 104.359 85.696  132.552 1.00 40.67  ? 456 PHE A CZ    1 
ATOM 3162 N N     . ALA A 1 457 ? 111.174 85.564  129.340 1.00 45.66  ? 457 ALA A N     1 
ATOM 3163 C CA    . ALA A 1 457 ? 112.159 84.980  128.452 1.00 43.45  ? 457 ALA A CA    1 
ATOM 3164 C C     . ALA A 1 457 ? 112.371 83.530  128.853 1.00 47.66  ? 457 ALA A C     1 
ATOM 3165 O O     . ALA A 1 457 ? 111.977 83.133  129.954 1.00 49.49  ? 457 ALA A O     1 
ATOM 3166 C CB    . ALA A 1 457 ? 113.463 85.776  128.536 1.00 43.40  ? 457 ALA A CB    1 
ATOM 3167 N N     . PRO A 1 458 ? 112.946 82.675  127.967 1.00 52.54  ? 458 PRO A N     1 
ATOM 3168 C CA    . PRO A 1 458 ? 113.330 81.326  128.420 1.00 55.86  ? 458 PRO A CA    1 
ATOM 3169 C C     . PRO A 1 458 ? 114.396 81.350  129.510 1.00 57.03  ? 458 PRO A C     1 
ATOM 3170 O O     . PRO A 1 458 ? 115.127 82.335  129.654 1.00 45.98  ? 458 PRO A O     1 
ATOM 3171 C CB    . PRO A 1 458 ? 113.836 80.642  127.143 1.00 51.98  ? 458 PRO A CB    1 
ATOM 3172 C CG    . PRO A 1 458 ? 113.297 81.438  126.021 1.00 47.63  ? 458 PRO A CG    1 
ATOM 3173 C CD    . PRO A 1 458 ? 113.093 82.826  126.504 1.00 47.77  ? 458 PRO A CD    1 
ATOM 3174 N N     . GLN A 1 459 ? 114.463 80.263  130.288 1.00 51.03  ? 459 GLN A N     1 
ATOM 3175 C CA    . GLN A 1 459 ? 115.123 80.269  131.589 1.00 51.18  ? 459 GLN A CA    1 
ATOM 3176 C C     . GLN A 1 459 ? 116.637 80.397  131.481 1.00 48.39  ? 459 GLN A C     1 
ATOM 3177 O O     . GLN A 1 459 ? 117.275 80.893  132.416 1.00 43.19  ? 459 GLN A O     1 
ATOM 3178 C CB    . GLN A 1 459 ? 114.815 78.977  132.361 1.00 48.78  ? 459 GLN A CB    1 
ATOM 3179 C CG    . GLN A 1 459 ? 113.370 78.637  132.846 1.00 45.83  ? 459 GLN A CG    1 
ATOM 3180 C CD    . GLN A 1 459 ? 112.280 78.568  131.771 1.00 47.36  ? 459 GLN A CD    1 
ATOM 3181 O OE1   . GLN A 1 459 ? 112.555 78.504  130.574 1.00 43.49  ? 459 GLN A OE1   1 
ATOM 3182 N NE2   . GLN A 1 459 ? 111.027 78.527  132.214 1.00 47.45  ? 459 GLN A NE2   1 
ATOM 3183 N N     . ARG A 1 460 ? 117.221 79.978  130.354 1.00 52.66  ? 460 ARG A N     1 
ATOM 3184 C CA    . ARG A 1 460 ? 118.656 80.083  130.123 1.00 49.95  ? 460 ARG A CA    1 
ATOM 3185 C C     . ARG A 1 460 ? 119.121 81.523  129.957 1.00 46.38  ? 460 ARG A C     1 
ATOM 3186 O O     . ARG A 1 460 ? 120.292 81.810  130.218 1.00 48.56  ? 460 ARG A O     1 
ATOM 3187 C CB    . ARG A 1 460 ? 119.058 79.270  128.883 1.00 48.97  ? 460 ARG A CB    1 
ATOM 3188 C CG    . ARG A 1 460 ? 118.300 77.959  128.671 1.00 47.89  ? 460 ARG A CG    1 
ATOM 3189 C CD    . ARG A 1 460 ? 118.839 76.822  129.568 1.00 44.38  ? 460 ARG A CD    1 
ATOM 3190 N NE    . ARG A 1 460 ? 118.204 76.681  130.880 1.00 43.12  ? 460 ARG A NE    1 
ATOM 3191 C CZ    . ARG A 1 460 ? 116.973 76.240  131.119 1.00 45.11  ? 460 ARG A CZ    1 
ATOM 3192 N NH1   . ARG A 1 460 ? 116.515 76.114  132.353 1.00 46.56  ? 460 ARG A NH1   1 
ATOM 3193 N NH2   . ARG A 1 460 ? 116.193 75.879  130.102 1.00 46.93  ? 460 ARG A NH2   1 
ATOM 3194 N N     . GLN A 1 461 ? 118.235 82.428  129.542 1.00 48.48  ? 461 GLN A N     1 
ATOM 3195 C CA    . GLN A 1 461 ? 118.620 83.816  129.289 1.00 51.06  ? 461 GLN A CA    1 
ATOM 3196 C C     . GLN A 1 461 ? 118.679 84.630  130.581 1.00 58.62  ? 461 GLN A C     1 
ATOM 3197 O O     . GLN A 1 461 ? 119.735 85.156  130.948 1.00 58.97  ? 461 GLN A O     1 
ATOM 3198 C CB    . GLN A 1 461 ? 117.644 84.437  128.281 1.00 51.45  ? 461 GLN A CB    1 
ATOM 3199 C CG    . GLN A 1 461 ? 117.744 83.918  126.831 1.00 57.26  ? 461 GLN A CG    1 
ATOM 3200 C CD    . GLN A 1 461 ? 117.049 82.579  126.573 1.00 60.48  ? 461 GLN A CD    1 
ATOM 3201 O OE1   . GLN A 1 461 ? 116.965 81.713  127.444 1.00 56.15  ? 461 GLN A OE1   1 
ATOM 3202 N NE2   . GLN A 1 461 ? 116.527 82.423  125.364 1.00 55.08  ? 461 GLN A NE2   1 
ATOM 3203 N N     . CYS A 1 462 ? 117.549 84.756  131.276 1.00 68.94  ? 462 CYS A N     1 
ATOM 3204 C CA    . CYS A 1 462 ? 117.538 85.386  132.591 1.00 60.93  ? 462 CYS A CA    1 
ATOM 3205 C C     . CYS A 1 462 ? 118.141 84.430  133.609 1.00 60.75  ? 462 CYS A C     1 
ATOM 3206 O O     . CYS A 1 462 ? 117.513 83.441  133.993 1.00 67.02  ? 462 CYS A O     1 
ATOM 3207 C CB    . CYS A 1 462 ? 116.105 85.752  132.986 1.00 57.48  ? 462 CYS A CB    1 
ATOM 3208 S SG    . CYS A 1 462 ? 114.865 84.488  132.541 1.00 70.19  ? 462 CYS A SG    1 
ATOM 3209 N N     . THR A 1 463 ? 119.366 84.696  134.036 1.00 54.76  ? 463 THR A N     1 
ATOM 3210 C CA    . THR A 1 463 ? 120.039 83.766  134.929 1.00 57.15  ? 463 THR A CA    1 
ATOM 3211 C C     . THR A 1 463 ? 120.192 84.371  136.314 1.00 58.07  ? 463 THR A C     1 
ATOM 3212 O O     . THR A 1 463 ? 120.142 85.590  136.486 1.00 62.95  ? 463 THR A O     1 
ATOM 3213 C CB    . THR A 1 463 ? 121.400 83.345  134.376 1.00 62.30  ? 463 THR A CB    1 
ATOM 3214 O OG1   . THR A 1 463 ? 122.124 82.625  135.382 1.00 63.48  ? 463 THR A OG1   1 
ATOM 3215 C CG2   . THR A 1 463 ? 122.184 84.543  133.921 1.00 55.03  ? 463 THR A CG2   1 
ATOM 3216 N N     . GLU A 1 464 ? 120.398 83.489  137.296 1.00 57.45  ? 464 GLU A N     1 
ATOM 3217 C CA    . GLU A 1 464 ? 120.107 83.807  138.692 1.00 61.37  ? 464 GLU A CA    1 
ATOM 3218 C C     . GLU A 1 464 ? 121.117 84.787  139.278 1.00 61.12  ? 464 GLU A C     1 
ATOM 3219 O O     . GLU A 1 464 ? 120.732 85.823  139.833 1.00 50.81  ? 464 GLU A O     1 
ATOM 3220 C CB    . GLU A 1 464 ? 120.062 82.528  139.540 1.00 55.21  ? 464 GLU A CB    1 
ATOM 3221 C CG    . GLU A 1 464 ? 119.434 81.284  138.896 1.00 55.94  ? 464 GLU A CG    1 
ATOM 3222 C CD    . GLU A 1 464 ? 120.411 80.468  138.056 1.00 59.03  ? 464 GLU A CD    1 
ATOM 3223 O OE1   . GLU A 1 464 ? 121.480 80.089  138.582 1.00 55.98  ? 464 GLU A OE1   1 
ATOM 3224 O OE2   . GLU A 1 464 ? 120.110 80.222  136.870 1.00 61.29  ? 464 GLU A OE2   1 
ATOM 3225 N N     . VAL A 1 465 ? 122.413 84.475  139.169 1.00 64.26  ? 465 VAL A N     1 
ATOM 3226 C CA    . VAL A 1 465 ? 123.436 85.319  139.785 1.00 56.49  ? 465 VAL A CA    1 
ATOM 3227 C C     . VAL A 1 465 ? 123.573 86.640  139.027 1.00 57.13  ? 465 VAL A C     1 
ATOM 3228 O O     . VAL A 1 465 ? 123.853 87.689  139.624 1.00 58.93  ? 465 VAL A O     1 
ATOM 3229 C CB    . VAL A 1 465 ? 124.770 84.545  139.906 1.00 57.82  ? 465 VAL A CB    1 
ATOM 3230 C CG1   . VAL A 1 465 ? 125.362 84.170  138.544 1.00 56.54  ? 465 VAL A CG1   1 
ATOM 3231 C CG2   . VAL A 1 465 ? 125.786 85.306  140.758 1.00 59.27  ? 465 VAL A CG2   1 
ATOM 3232 N N     . HIS A 1 466 ? 123.299 86.631  137.720 1.00 63.99  ? 466 HIS A N     1 
ATOM 3233 C CA    . HIS A 1 466 ? 123.342 87.880  136.974 1.00 64.51  ? 466 HIS A CA    1 
ATOM 3234 C C     . HIS A 1 466 ? 122.123 88.740  137.273 1.00 62.19  ? 466 HIS A C     1 
ATOM 3235 O O     . HIS A 1 466 ? 122.234 89.970  137.299 1.00 65.75  ? 466 HIS A O     1 
ATOM 3236 C CB    . HIS A 1 466 ? 123.476 87.612  135.477 1.00 67.58  ? 466 HIS A CB    1 
ATOM 3237 C CG    . HIS A 1 466 ? 124.775 86.969  135.096 1.00 72.23  ? 466 HIS A CG    1 
ATOM 3238 N ND1   . HIS A 1 466 ? 125.836 86.860  135.969 1.00 73.75  ? 466 HIS A ND1   1 
ATOM 3239 C CD2   . HIS A 1 466 ? 125.186 86.407  133.935 1.00 68.15  ? 466 HIS A CD2   1 
ATOM 3240 C CE1   . HIS A 1 466 ? 126.841 86.251  135.366 1.00 67.95  ? 466 HIS A CE1   1 
ATOM 3241 N NE2   . HIS A 1 466 ? 126.472 85.966  134.130 1.00 67.16  ? 466 HIS A NE2   1 
ATOM 3242 N N     . LEU A 1 467 ? 120.973 88.115  137.544 1.00 46.16  ? 467 LEU A N     1 
ATOM 3243 C CA    . LEU A 1 467 ? 119.814 88.872  138.008 1.00 46.13  ? 467 LEU A CA    1 
ATOM 3244 C C     . LEU A 1 467 ? 120.047 89.441  139.402 1.00 51.76  ? 467 LEU A C     1 
ATOM 3245 O O     . LEU A 1 467 ? 119.605 90.555  139.702 1.00 47.57  ? 467 LEU A O     1 
ATOM 3246 C CB    . LEU A 1 467 ? 118.565 87.997  138.002 1.00 38.79  ? 467 LEU A CB    1 
ATOM 3247 C CG    . LEU A 1 467 ? 117.682 88.189  136.775 1.00 45.10  ? 467 LEU A CG    1 
ATOM 3248 C CD1   . LEU A 1 467 ? 116.553 87.168  136.765 1.00 47.81  ? 467 LEU A CD1   1 
ATOM 3249 C CD2   . LEU A 1 467 ? 117.139 89.606  136.714 1.00 40.56  ? 467 LEU A CD2   1 
ATOM 3250 N N     . LYS A 1 468 ? 120.758 88.697  140.256 1.00 54.03  ? 468 LYS A N     1 
ATOM 3251 C CA    . LYS A 1 468 ? 121.076 89.197  141.592 1.00 44.96  ? 468 LYS A CA    1 
ATOM 3252 C C     . LYS A 1 468 ? 122.055 90.366  141.536 1.00 40.93  ? 468 LYS A C     1 
ATOM 3253 O O     . LYS A 1 468 ? 121.904 91.339  142.282 1.00 42.72  ? 468 LYS A O     1 
ATOM 3254 C CB    . LYS A 1 468 ? 121.633 88.072  142.464 1.00 47.08  ? 468 LYS A CB    1 
ATOM 3255 C CG    . LYS A 1 468 ? 120.584 87.063  142.913 1.00 47.32  ? 468 LYS A CG    1 
ATOM 3256 C CD    . LYS A 1 468 ? 119.555 87.686  143.847 1.00 45.86  ? 468 LYS A CD    1 
ATOM 3257 C CE    . LYS A 1 468 ? 118.282 86.851  143.896 1.00 44.59  ? 468 LYS A CE    1 
ATOM 3258 N NZ    . LYS A 1 468 ? 117.695 86.795  145.263 1.00 43.70  ? 468 LYS A NZ    1 
ATOM 3259 N N     . SER A 1 469 ? 123.051 90.305  140.644 1.00 49.42  ? 469 SER A N     1 
ATOM 3260 C CA    . SER A 1 469 ? 123.991 91.420  140.537 1.00 48.69  ? 469 SER A CA    1 
ATOM 3261 C C     . SER A 1 469 ? 123.356 92.627  139.854 1.00 45.16  ? 469 SER A C     1 
ATOM 3262 O O     . SER A 1 469 ? 123.672 93.769  140.208 1.00 45.05  ? 469 SER A O     1 
ATOM 3263 C CB    . SER A 1 469 ? 125.262 90.997  139.802 1.00 50.93  ? 469 SER A CB    1 
ATOM 3264 O OG    . SER A 1 469 ? 124.987 90.052  138.796 1.00 48.65  ? 469 SER A OG    1 
ATOM 3265 N N     . PHE A 1 470 ? 122.457 92.395  138.882 1.00 33.64  ? 470 PHE A N     1 
ATOM 3266 C CA    . PHE A 1 470 ? 121.675 93.479  138.287 1.00 27.12  ? 470 PHE A CA    1 
ATOM 3267 C C     . PHE A 1 470 ? 120.804 94.158  139.328 1.00 35.04  ? 470 PHE A C     1 
ATOM 3268 O O     . PHE A 1 470 ? 120.765 95.393  139.400 1.00 41.89  ? 470 PHE A O     1 
ATOM 3269 C CB    . PHE A 1 470 ? 120.823 92.935  137.132 1.00 31.03  ? 470 PHE A CB    1 
ATOM 3270 C CG    . PHE A 1 470 ? 119.464 93.599  136.973 1.00 33.54  ? 470 PHE A CG    1 
ATOM 3271 C CD1   . PHE A 1 470 ? 119.338 94.806  136.312 1.00 31.15  ? 470 PHE A CD1   1 
ATOM 3272 C CD2   . PHE A 1 470 ? 118.305 92.986  137.445 1.00 41.67  ? 470 PHE A CD2   1 
ATOM 3273 C CE1   . PHE A 1 470 ? 118.094 95.405  136.152 1.00 24.09  ? 470 PHE A CE1   1 
ATOM 3274 C CE2   . PHE A 1 470 ? 117.064 93.591  137.289 1.00 33.84  ? 470 PHE A CE2   1 
ATOM 3275 C CZ    . PHE A 1 470 ? 116.964 94.799  136.641 1.00 24.55  ? 470 PHE A CZ    1 
ATOM 3276 N N     . THR A 1 471 ? 120.129 93.360  140.165 1.00 41.98  ? 471 THR A N     1 
ATOM 3277 C CA    . THR A 1 471 ? 119.294 93.900  141.229 1.00 47.40  ? 471 THR A CA    1 
ATOM 3278 C C     . THR A 1 471 ? 120.120 94.668  142.250 1.00 43.44  ? 471 THR A C     1 
ATOM 3279 O O     . THR A 1 471 ? 119.750 95.784  142.625 1.00 40.32  ? 471 THR A O     1 
ATOM 3280 C CB    . THR A 1 471 ? 118.525 92.772  141.915 1.00 49.28  ? 471 THR A CB    1 
ATOM 3281 O OG1   . THR A 1 471 ? 118.080 91.827  140.934 1.00 44.22  ? 471 THR A OG1   1 
ATOM 3282 C CG2   . THR A 1 471 ? 117.323 93.331  142.655 1.00 45.53  ? 471 THR A CG2   1 
ATOM 3283 N N     . GLU A 1 472 ? 121.278 94.118  142.644 1.00 43.54  ? 472 GLU A N     1 
ATOM 3284 C CA    . GLU A 1 472 ? 122.107 94.728  143.681 1.00 41.27  ? 472 GLU A CA    1 
ATOM 3285 C C     . GLU A 1 472 ? 122.738 96.028  143.198 1.00 47.89  ? 472 GLU A C     1 
ATOM 3286 O O     . GLU A 1 472 ? 122.782 97.017  143.939 1.00 43.65  ? 472 GLU A O     1 
ATOM 3287 C CB    . GLU A 1 472 ? 123.156 93.708  144.164 1.00 43.37  ? 472 GLU A CB    1 
ATOM 3288 C CG    . GLU A 1 472 ? 124.490 94.191  144.818 1.00 48.08  ? 472 GLU A CG    1 
ATOM 3289 C CD    . GLU A 1 472 ? 125.579 94.660  143.845 1.00 52.20  ? 472 GLU A CD    1 
ATOM 3290 O OE1   . GLU A 1 472 ? 125.904 93.912  142.900 1.00 53.73  ? 472 GLU A OE1   1 
ATOM 3291 O OE2   . GLU A 1 472 ? 126.101 95.778  144.035 1.00 48.91  ? 472 GLU A OE2   1 
ATOM 3292 N N     . GLN A 1 473 ? 123.231 96.051  141.958 1.00 52.21  ? 473 GLN A N     1 
ATOM 3293 C CA    . GLN A 1 473 ? 123.855 97.266  141.452 1.00 42.46  ? 473 GLN A CA    1 
ATOM 3294 C C     . GLN A 1 473 ? 122.795 98.313  141.129 1.00 44.21  ? 473 GLN A C     1 
ATOM 3295 O O     . GLN A 1 473 ? 123.044 99.520  141.255 1.00 49.92  ? 473 GLN A O     1 
ATOM 3296 C CB    . GLN A 1 473 ? 124.739 96.928  140.248 1.00 43.50  ? 473 GLN A CB    1 
ATOM 3297 C CG    . GLN A 1 473 ? 125.517 98.090  139.656 1.00 50.37  ? 473 GLN A CG    1 
ATOM 3298 C CD    . GLN A 1 473 ? 124.799 98.706  138.492 1.00 52.33  ? 473 GLN A CD    1 
ATOM 3299 O OE1   . GLN A 1 473 ? 124.066 98.019  137.791 1.00 56.35  ? 473 GLN A OE1   1 
ATOM 3300 N NE2   . GLN A 1 473 ? 124.993 100.002 138.279 1.00 44.87  ? 473 GLN A NE2   1 
ATOM 3301 N N     . LEU A 1 474 ? 121.578 97.858  140.797 1.00 37.02  ? 474 LEU A N     1 
ATOM 3302 C CA    . LEU A 1 474 ? 120.434 98.754  140.662 1.00 34.20  ? 474 LEU A CA    1 
ATOM 3303 C C     . LEU A 1 474 ? 120.108 99.448  141.980 1.00 41.01  ? 474 LEU A C     1 
ATOM 3304 O O     . LEU A 1 474 ? 119.956 100.674 142.016 1.00 45.95  ? 474 LEU A O     1 
ATOM 3305 C CB    . LEU A 1 474 ? 119.224 97.964  140.167 1.00 31.90  ? 474 LEU A CB    1 
ATOM 3306 C CG    . LEU A 1 474 ? 117.870 98.656  140.060 1.00 28.41  ? 474 LEU A CG    1 
ATOM 3307 C CD1   . LEU A 1 474 ? 117.707 99.235  138.688 1.00 27.24  ? 474 LEU A CD1   1 
ATOM 3308 C CD2   . LEU A 1 474 ? 116.765 97.672  140.345 1.00 38.35  ? 474 LEU A CD2   1 
ATOM 3309 N N     . ARG A 1 475 ? 120.040 98.693  143.089 1.00 40.09  ? 475 ARG A N     1 
ATOM 3310 C CA    . ARG A 1 475 ? 119.682 99.346  144.351 1.00 36.99  ? 475 ARG A CA    1 
ATOM 3311 C C     . ARG A 1 475 ? 120.848 100.152 144.909 1.00 43.13  ? 475 ARG A C     1 
ATOM 3312 O O     . ARG A 1 475 ? 120.631 101.132 145.626 1.00 47.52  ? 475 ARG A O     1 
ATOM 3313 C CB    . ARG A 1 475 ? 119.203 98.367  145.428 1.00 44.26  ? 475 ARG A CB    1 
ATOM 3314 C CG    . ARG A 1 475 ? 119.901 97.052  145.509 1.00 47.14  ? 475 ARG A CG    1 
ATOM 3315 C CD    . ARG A 1 475 ? 119.201 96.055  146.408 1.00 47.44  ? 475 ARG A CD    1 
ATOM 3316 N NE    . ARG A 1 475 ? 119.494 96.306  147.813 1.00 43.91  ? 475 ARG A NE    1 
ATOM 3317 C CZ    . ARG A 1 475 ? 119.034 95.571  148.813 1.00 46.11  ? 475 ARG A CZ    1 
ATOM 3318 N NH1   . ARG A 1 475 ? 118.291 94.499  148.595 1.00 46.55  ? 475 ARG A NH1   1 
ATOM 3319 N NH2   . ARG A 1 475 ? 119.334 95.913  150.062 1.00 48.62  ? 475 ARG A NH2   1 
ATOM 3320 N N     . LYS A 1 476 ? 122.092 99.779  144.585 1.00 46.37  ? 476 LYS A N     1 
ATOM 3321 C CA    . LYS A 1 476 ? 123.214 100.558 145.103 1.00 50.27  ? 476 LYS A CA    1 
ATOM 3322 C C     . LYS A 1 476 ? 123.352 101.887 144.356 1.00 44.81  ? 476 LYS A C     1 
ATOM 3323 O O     . LYS A 1 476 ? 123.566 102.935 144.982 1.00 45.98  ? 476 LYS A O     1 
ATOM 3324 C CB    . LYS A 1 476 ? 124.515 99.729  145.099 1.00 49.45  ? 476 LYS A CB    1 
ATOM 3325 C CG    . LYS A 1 476 ? 125.354 99.664  143.823 1.00 51.66  ? 476 LYS A CG    1 
ATOM 3326 C CD    . LYS A 1 476 ? 126.770 99.187  144.096 1.00 51.60  ? 476 LYS A CD    1 
ATOM 3327 C CE    . LYS A 1 476 ? 127.715 99.608  142.982 1.00 50.38  ? 476 LYS A CE    1 
ATOM 3328 N NZ    . LYS A 1 476 ? 127.817 101.088 142.875 1.00 42.74  ? 476 LYS A NZ    1 
ATOM 3329 N N     . ILE A 1 477 ? 123.116 101.897 143.037 1.00 28.24  ? 477 ILE A N     1 
ATOM 3330 C CA    . ILE A 1 477 ? 123.175 103.170 142.328 1.00 36.73  ? 477 ILE A CA    1 
ATOM 3331 C C     . ILE A 1 477 ? 121.888 103.948 142.549 1.00 39.27  ? 477 ILE A C     1 
ATOM 3332 O O     . ILE A 1 477 ? 121.852 105.173 142.388 1.00 41.47  ? 477 ILE A O     1 
ATOM 3333 C CB    . ILE A 1 477 ? 123.490 102.961 140.832 1.00 38.04  ? 477 ILE A CB    1 
ATOM 3334 C CG1   . ILE A 1 477 ? 124.313 104.138 140.302 1.00 41.12  ? 477 ILE A CG1   1 
ATOM 3335 C CG2   . ILE A 1 477 ? 122.224 102.806 139.990 1.00 37.25  ? 477 ILE A CG2   1 
ATOM 3336 C CD1   . ILE A 1 477 ? 125.224 103.774 139.153 1.00 36.96  ? 477 ILE A CD1   1 
ATOM 3337 N N     . SER A 1 478 ? 120.830 103.269 142.992 1.00 38.34  ? 478 SER A N     1 
ATOM 3338 C CA    . SER A 1 478 ? 119.602 103.983 143.266 1.00 37.57  ? 478 SER A CA    1 
ATOM 3339 C C     . SER A 1 478 ? 119.588 104.528 144.690 1.00 39.85  ? 478 SER A C     1 
ATOM 3340 O O     . SER A 1 478 ? 118.861 105.483 144.967 1.00 42.49  ? 478 SER A O     1 
ATOM 3341 C CB    . SER A 1 478 ? 118.415 103.064 142.997 1.00 32.57  ? 478 SER A CB    1 
ATOM 3342 O OG    . SER A 1 478 ? 117.269 103.816 142.673 1.00 30.97  ? 478 SER A OG    1 
ATOM 3343 N N     . ARG A 1 479 ? 120.388 103.950 145.599 1.00 37.79  ? 479 ARG A N     1 
ATOM 3344 C CA    . ARG A 1 479 ? 120.634 104.598 146.886 1.00 35.20  ? 479 ARG A CA    1 
ATOM 3345 C C     . ARG A 1 479 ? 121.606 105.753 146.724 1.00 39.64  ? 479 ARG A C     1 
ATOM 3346 O O     . ARG A 1 479 ? 121.532 106.740 147.466 1.00 43.02  ? 479 ARG A O     1 
ATOM 3347 C CB    . ARG A 1 479 ? 121.204 103.622 147.916 1.00 36.31  ? 479 ARG A CB    1 
ATOM 3348 C CG    . ARG A 1 479 ? 120.190 102.999 148.845 1.00 41.92  ? 479 ARG A CG    1 
ATOM 3349 C CD    . ARG A 1 479 ? 120.750 101.751 149.509 1.00 39.18  ? 479 ARG A CD    1 
ATOM 3350 N NE    . ARG A 1 479 ? 121.161 100.710 148.578 1.00 40.85  ? 479 ARG A NE    1 
ATOM 3351 C CZ    . ARG A 1 479 ? 121.122 99.414  148.851 1.00 44.72  ? 479 ARG A CZ    1 
ATOM 3352 N NH1   . ARG A 1 479 ? 120.616 98.962  149.987 1.00 40.74  ? 479 ARG A NH1   1 
ATOM 3353 N NH2   . ARG A 1 479 ? 121.619 98.553  147.970 1.00 42.91  ? 479 ARG A NH2   1 
ATOM 3354 N N     . ASP A 1 480 ? 122.558 105.619 145.791 1.00 44.17  ? 480 ASP A N     1 
ATOM 3355 C CA    . ASP A 1 480 ? 123.426 106.741 145.449 1.00 47.10  ? 480 ASP A CA    1 
ATOM 3356 C C     . ASP A 1 480 ? 122.623 107.880 144.836 1.00 43.90  ? 480 ASP A C     1 
ATOM 3357 O O     . ASP A 1 480 ? 122.917 109.057 145.073 1.00 38.87  ? 480 ASP A O     1 
ATOM 3358 C CB    . ASP A 1 480 ? 124.526 106.284 144.492 1.00 40.90  ? 480 ASP A CB    1 
ATOM 3359 C CG    . ASP A 1 480 ? 125.850 106.970 144.759 1.00 39.45  ? 480 ASP A CG    1 
ATOM 3360 O OD1   . ASP A 1 480 ? 125.848 108.199 144.972 1.00 42.51  ? 480 ASP A OD1   1 
ATOM 3361 O OD2   . ASP A 1 480 ? 126.892 106.280 144.757 1.00 42.60  ? 480 ASP A OD2   1 
ATOM 3362 N N     . ALA A 1 481 ? 121.599 107.548 144.058 1.00 44.14  ? 481 ALA A N     1 
ATOM 3363 C CA    . ALA A 1 481 ? 120.679 108.544 143.535 1.00 43.77  ? 481 ALA A CA    1 
ATOM 3364 C C     . ALA A 1 481 ? 119.459 108.752 144.426 1.00 35.57  ? 481 ALA A C     1 
ATOM 3365 O O     . ALA A 1 481 ? 118.654 109.641 144.143 1.00 32.40  ? 481 ALA A O     1 
ATOM 3366 C CB    . ALA A 1 481 ? 120.240 108.162 142.120 1.00 48.38  ? 481 ALA A CB    1 
ATOM 3367 N N     . GLY A 1 482 ? 119.298 107.969 145.492 1.00 33.20  ? 482 GLY A N     1 
ATOM 3368 C CA    . GLY A 1 482 ? 118.316 108.316 146.505 1.00 42.62  ? 482 GLY A CA    1 
ATOM 3369 C C     . GLY A 1 482 ? 117.026 107.518 146.570 1.00 39.39  ? 482 GLY A C     1 
ATOM 3370 O O     . GLY A 1 482 ? 115.953 108.102 146.760 1.00 34.80  ? 482 GLY A O     1 
ATOM 3371 N N     . MET A 1 483 ? 117.101 106.192 146.428 1.00 47.85  ? 483 MET A N     1 
ATOM 3372 C CA    . MET A 1 483 ? 115.932 105.339 146.615 1.00 42.15  ? 483 MET A CA    1 
ATOM 3373 C C     . MET A 1 483 ? 116.053 104.557 147.907 1.00 41.53  ? 483 MET A C     1 
ATOM 3374 O O     . MET A 1 483 ? 117.131 104.014 148.194 1.00 44.03  ? 483 MET A O     1 
ATOM 3375 C CB    . MET A 1 483 ? 115.769 104.361 145.469 1.00 36.17  ? 483 MET A CB    1 
ATOM 3376 C CG    . MET A 1 483 ? 114.331 104.001 145.179 1.00 38.20  ? 483 MET A CG    1 
ATOM 3377 S SD    . MET A 1 483 ? 113.526 105.157 144.079 1.00 38.29  ? 483 MET A SD    1 
ATOM 3378 C CE    . MET A 1 483 ? 113.998 104.385 142.540 1.00 26.97  ? 483 MET A CE    1 
ATOM 3379 N N     . PRO A 1 484 ? 115.004 104.455 148.695 1.00 45.03  ? 484 PRO A N     1 
ATOM 3380 C CA    . PRO A 1 484 ? 115.001 103.461 149.783 1.00 42.57  ? 484 PRO A CA    1 
ATOM 3381 C C     . PRO A 1 484 ? 114.463 102.107 149.320 1.00 48.21  ? 484 PRO A C     1 
ATOM 3382 O O     . PRO A 1 484 ? 113.345 101.691 149.629 1.00 49.05  ? 484 PRO A O     1 
ATOM 3383 C CB    . PRO A 1 484 ? 114.101 104.115 150.834 1.00 38.07  ? 484 PRO A CB    1 
ATOM 3384 C CG    . PRO A 1 484 ? 113.225 105.057 150.077 1.00 41.75  ? 484 PRO A CG    1 
ATOM 3385 C CD    . PRO A 1 484 ? 113.856 105.373 148.758 1.00 47.83  ? 484 PRO A CD    1 
ATOM 3386 N N     . ILE A 1 485 ? 115.284 101.381 148.560 1.00 45.71  ? 485 ILE A N     1 
ATOM 3387 C CA    . ILE A 1 485 ? 114.942 100.035 148.110 1.00 40.59  ? 485 ILE A CA    1 
ATOM 3388 C C     . ILE A 1 485 ? 115.101 99.092  149.296 1.00 35.20  ? 485 ILE A C     1 
ATOM 3389 O O     . ILE A 1 485 ? 116.199 98.949  149.845 1.00 37.18  ? 485 ILE A O     1 
ATOM 3390 C CB    . ILE A 1 485 ? 115.826 99.592  146.934 1.00 34.95  ? 485 ILE A CB    1 
ATOM 3391 C CG1   . ILE A 1 485 ? 115.535 100.427 145.681 1.00 39.18  ? 485 ILE A CG1   1 
ATOM 3392 C CG2   . ILE A 1 485 ? 115.659 98.095  146.667 1.00 30.23  ? 485 ILE A CG2   1 
ATOM 3393 C CD1   . ILE A 1 485 ? 114.360 99.960  144.843 1.00 29.75  ? 485 ILE A CD1   1 
ATOM 3394 N N     . GLN A 1 486 ? 114.007 98.455  149.700 1.00 33.58  ? 486 GLN A N     1 
ATOM 3395 C CA    . GLN A 1 486 ? 114.005 97.566  150.852 1.00 40.91  ? 486 GLN A CA    1 
ATOM 3396 C C     . GLN A 1 486 ? 114.020 96.117  150.388 1.00 43.22  ? 486 GLN A C     1 
ATOM 3397 O O     . GLN A 1 486 ? 113.003 95.598  149.919 1.00 42.89  ? 486 GLN A O     1 
ATOM 3398 C CB    . GLN A 1 486 ? 112.794 97.825  151.749 1.00 46.39  ? 486 GLN A CB    1 
ATOM 3399 C CG    . GLN A 1 486 ? 112.602 99.276  152.165 1.00 43.44  ? 486 GLN A CG    1 
ATOM 3400 C CD    . GLN A 1 486 ? 113.847 99.875  152.796 1.00 41.96  ? 486 GLN A CD    1 
ATOM 3401 O OE1   . GLN A 1 486 ? 114.476 99.266  153.664 1.00 40.23  ? 486 GLN A OE1   1 
ATOM 3402 N NE2   . GLN A 1 486 ? 114.203 101.077 152.371 1.00 42.37  ? 486 GLN A NE2   1 
ATOM 3403 N N     . GLY A 1 487 ? 115.176 95.478  150.510 1.00 42.32  ? 487 GLY A N     1 
ATOM 3404 C CA    . GLY A 1 487 ? 115.264 94.041  150.371 1.00 40.22  ? 487 GLY A CA    1 
ATOM 3405 C C     . GLY A 1 487 ? 115.254 93.516  148.953 1.00 42.89  ? 487 GLY A C     1 
ATOM 3406 O O     . GLY A 1 487 ? 114.940 94.238  148.003 1.00 40.89  ? 487 GLY A O     1 
ATOM 3407 N N     . GLN A 1 488 ? 115.602 92.240  148.815 1.00 49.81  ? 488 GLN A N     1 
ATOM 3408 C CA    . GLN A 1 488 ? 115.554 91.558  147.539 1.00 48.25  ? 488 GLN A CA    1 
ATOM 3409 C C     . GLN A 1 488 ? 114.097 91.346  147.126 1.00 50.65  ? 488 GLN A C     1 
ATOM 3410 O O     . GLN A 1 488 ? 113.199 91.391  147.970 1.00 51.56  ? 488 GLN A O     1 
ATOM 3411 C CB    . GLN A 1 488 ? 116.302 90.226  147.639 1.00 45.23  ? 488 GLN A CB    1 
ATOM 3412 C CG    . GLN A 1 488 ? 115.742 89.253  148.666 1.00 49.24  ? 488 GLN A CG    1 
ATOM 3413 C CD    . GLN A 1 488 ? 115.108 88.032  148.026 1.00 52.45  ? 488 GLN A CD    1 
ATOM 3414 O OE1   . GLN A 1 488 ? 115.650 87.462  147.080 1.00 58.05  ? 488 GLN A OE1   1 
ATOM 3415 N NE2   . GLN A 1 488 ? 113.948 87.633  148.533 1.00 46.71  ? 488 GLN A NE2   1 
ATOM 3416 N N     . PRO A 1 489 ? 113.829 91.179  145.825 1.00 51.55  ? 489 PRO A N     1 
ATOM 3417 C CA    . PRO A 1 489 ? 112.465 90.838  145.401 1.00 48.95  ? 489 PRO A CA    1 
ATOM 3418 C C     . PRO A 1 489 ? 112.025 89.474  145.921 1.00 54.39  ? 489 PRO A C     1 
ATOM 3419 O O     . PRO A 1 489 ? 112.812 88.528  146.000 1.00 54.19  ? 489 PRO A O     1 
ATOM 3420 C CB    . PRO A 1 489 ? 112.552 90.854  143.869 1.00 43.20  ? 489 PRO A CB    1 
ATOM 3421 C CG    . PRO A 1 489 ? 114.009 90.780  143.559 1.00 50.02  ? 489 PRO A CG    1 
ATOM 3422 C CD    . PRO A 1 489 ? 114.677 91.512  144.668 1.00 52.71  ? 489 PRO A CD    1 
ATOM 3423 N N     . CYS A 1 490 ? 110.740 89.391  146.280 1.00 57.16  ? 490 CYS A N     1 
ATOM 3424 C CA    . CYS A 1 490 ? 110.234 88.231  147.010 1.00 53.27  ? 490 CYS A CA    1 
ATOM 3425 C C     . CYS A 1 490 ? 110.092 87.012  146.105 1.00 51.53  ? 490 CYS A C     1 
ATOM 3426 O O     . CYS A 1 490 ? 110.422 85.890  146.507 1.00 58.66  ? 490 CYS A O     1 
ATOM 3427 C CB    . CYS A 1 490 ? 108.898 88.570  147.667 1.00 53.68  ? 490 CYS A CB    1 
ATOM 3428 S SG    . CYS A 1 490 ? 107.685 89.294  146.548 1.00 57.04  ? 490 CYS A SG    1 
ATOM 3429 N N     . PHE A 1 491 ? 109.600 87.206  144.884 1.00 39.99  ? 491 PHE A N     1 
ATOM 3430 C CA    . PHE A 1 491 ? 109.374 86.113  143.949 1.00 43.80  ? 491 PHE A CA    1 
ATOM 3431 C C     . PHE A 1 491 ? 110.144 86.353  142.660 1.00 47.70  ? 491 PHE A C     1 
ATOM 3432 O O     . PHE A 1 491 ? 109.925 87.360  141.979 1.00 45.98  ? 491 PHE A O     1 
ATOM 3433 C CB    . PHE A 1 491 ? 107.886 85.949  143.638 1.00 52.30  ? 491 PHE A CB    1 
ATOM 3434 C CG    . PHE A 1 491 ? 107.489 84.537  143.318 1.00 59.78  ? 491 PHE A CG    1 
ATOM 3435 C CD1   . PHE A 1 491 ? 108.077 83.468  143.983 1.00 53.38  ? 491 PHE A CD1   1 
ATOM 3436 C CD2   . PHE A 1 491 ? 106.536 84.277  142.345 1.00 59.64  ? 491 PHE A CD2   1 
ATOM 3437 C CE1   . PHE A 1 491 ? 107.712 82.164  143.688 1.00 49.64  ? 491 PHE A CE1   1 
ATOM 3438 C CE2   . PHE A 1 491 ? 106.170 82.978  142.041 1.00 48.78  ? 491 PHE A CE2   1 
ATOM 3439 C CZ    . PHE A 1 491 ? 106.756 81.920  142.715 1.00 48.09  ? 491 PHE A CZ    1 
ATOM 3440 N N     . CYS A 1 492 ? 111.026 85.414  142.322 1.00 58.19  ? 492 CYS A N     1 
ATOM 3441 C CA    . CYS A 1 492 ? 111.764 85.415  141.060 1.00 53.99  ? 492 CYS A CA    1 
ATOM 3442 C C     . CYS A 1 492 ? 111.449 84.109  140.336 1.00 51.35  ? 492 CYS A C     1 
ATOM 3443 O O     . CYS A 1 492 ? 112.135 83.099  140.523 1.00 52.81  ? 492 CYS A O     1 
ATOM 3444 C CB    . CYS A 1 492 ? 113.262 85.585  141.293 1.00 48.59  ? 492 CYS A CB    1 
ATOM 3445 S SG    . CYS A 1 492 ? 113.919 84.715  142.733 1.00 52.70  ? 492 CYS A SG    1 
ATOM 3446 N N     . LYS A 1 493 ? 110.414 84.136  139.502 1.00 42.06  ? 493 LYS A N     1 
ATOM 3447 C CA    . LYS A 1 493 ? 109.918 82.949  138.814 1.00 49.99  ? 493 LYS A CA    1 
ATOM 3448 C C     . LYS A 1 493 ? 110.465 82.974  137.392 1.00 41.28  ? 493 LYS A C     1 
ATOM 3449 O O     . LYS A 1 493 ? 110.789 84.039  136.858 1.00 44.19  ? 493 LYS A O     1 
ATOM 3450 C CB    . LYS A 1 493 ? 108.390 82.895  138.843 1.00 55.03  ? 493 LYS A CB    1 
ATOM 3451 C CG    . LYS A 1 493 ? 107.696 83.442  137.613 1.00 49.22  ? 493 LYS A CG    1 
ATOM 3452 C CD    . LYS A 1 493 ? 106.241 83.713  137.893 1.00 43.15  ? 493 LYS A CD    1 
ATOM 3453 C CE    . LYS A 1 493 ? 106.043 84.912  138.800 1.00 45.26  ? 493 LYS A CE    1 
ATOM 3454 N NZ    . LYS A 1 493 ? 104.648 85.416  138.719 1.00 49.45  ? 493 LYS A NZ    1 
ATOM 3455 N N     . TYR A 1 494 ? 110.583 81.795  136.789 1.00 44.46  ? 494 TYR A N     1 
ATOM 3456 C CA    . TYR A 1 494 ? 111.263 81.693  135.509 1.00 42.84  ? 494 TYR A CA    1 
ATOM 3457 C C     . TYR A 1 494 ? 110.352 81.026  134.489 1.00 50.41  ? 494 TYR A C     1 
ATOM 3458 O O     . TYR A 1 494 ? 110.508 79.832  134.217 1.00 54.01  ? 494 TYR A O     1 
ATOM 3459 C CB    . TYR A 1 494 ? 112.527 80.863  135.666 1.00 47.73  ? 494 TYR A CB    1 
ATOM 3460 C CG    . TYR A 1 494 ? 113.749 81.656  136.017 1.00 46.50  ? 494 TYR A CG    1 
ATOM 3461 C CD1   . TYR A 1 494 ? 113.861 82.995  135.679 1.00 52.55  ? 494 TYR A CD1   1 
ATOM 3462 C CD2   . TYR A 1 494 ? 114.795 81.063  136.713 1.00 47.60  ? 494 TYR A CD2   1 
ATOM 3463 C CE1   . TYR A 1 494 ? 114.983 83.721  136.019 1.00 55.70  ? 494 TYR A CE1   1 
ATOM 3464 C CE2   . TYR A 1 494 ? 115.922 81.774  137.050 1.00 47.90  ? 494 TYR A CE2   1 
ATOM 3465 C CZ    . TYR A 1 494 ? 116.010 83.103  136.704 1.00 54.09  ? 494 TYR A CZ    1 
ATOM 3466 O OH    . TYR A 1 494 ? 117.131 83.820  137.037 1.00 56.53  ? 494 TYR A OH    1 
ATOM 3467 N N     . ALA A 1 495 ? 109.426 81.773  133.886 1.00 47.28  ? 495 ALA A N     1 
ATOM 3468 C CA    . ALA A 1 495 ? 108.400 81.131  133.073 1.00 50.37  ? 495 ALA A CA    1 
ATOM 3469 C C     . ALA A 1 495 ? 108.883 80.818  131.662 1.00 50.04  ? 495 ALA A C     1 
ATOM 3470 O O     . ALA A 1 495 ? 110.071 80.950  131.355 1.00 45.98  ? 495 ALA A O     1 
ATOM 3471 C CB    . ALA A 1 495 ? 107.141 81.991  133.009 1.00 44.32  ? 495 ALA A CB    1 
ATOM 3472 N N     . GLN A 1 496 ? 107.969 80.409  130.783 1.00 42.19  ? 496 GLN A N     1 
ATOM 3473 C CA    . GLN A 1 496 ? 108.404 79.950  129.469 1.00 33.98  ? 496 GLN A CA    1 
ATOM 3474 C C     . GLN A 1 496 ? 107.950 80.910  128.378 1.00 35.31  ? 496 GLN A C     1 
ATOM 3475 O O     . GLN A 1 496 ? 108.769 81.373  127.579 1.00 35.86  ? 496 GLN A O     1 
ATOM 3476 C CB    . GLN A 1 496 ? 107.896 78.532  129.167 1.00 38.18  ? 496 GLN A CB    1 
ATOM 3477 C CG    . GLN A 1 496 ? 108.066 77.476  130.278 1.00 44.43  ? 496 GLN A CG    1 
ATOM 3478 C CD    . GLN A 1 496 ? 106.940 77.490  131.309 1.00 41.64  ? 496 GLN A CD    1 
ATOM 3479 O OE1   . GLN A 1 496 ? 106.711 78.494  131.979 1.00 42.15  ? 496 GLN A OE1   1 
ATOM 3480 N NE2   . GLN A 1 496 ? 106.242 76.369  131.443 1.00 38.52  ? 496 GLN A NE2   1 
ATOM 3481 N N     . GLY A 1 497 ? 106.661 81.217  128.337 1.00 41.87  ? 497 GLY A N     1 
ATOM 3482 C CA    . GLY A 1 497 ? 106.139 82.001  127.236 1.00 41.94  ? 497 GLY A CA    1 
ATOM 3483 C C     . GLY A 1 497 ? 104.691 82.367  127.466 1.00 45.36  ? 497 GLY A C     1 
ATOM 3484 O O     . GLY A 1 497 ? 104.198 82.380  128.597 1.00 52.08  ? 497 GLY A O     1 
ATOM 3485 N N     . ALA A 1 498 ? 104.009 82.647  126.348 1.00 48.33  ? 498 ALA A N     1 
ATOM 3486 C CA    . ALA A 1 498 ? 102.714 83.326  126.376 1.00 49.93  ? 498 ALA A CA    1 
ATOM 3487 C C     . ALA A 1 498 ? 101.566 82.421  126.801 1.00 54.60  ? 498 ALA A C     1 
ATOM 3488 O O     . ALA A 1 498 ? 100.441 82.902  126.987 1.00 55.31  ? 498 ALA A O     1 
ATOM 3489 C CB    . ALA A 1 498 ? 102.405 83.905  124.996 1.00 50.24  ? 498 ALA A CB    1 
ATOM 3490 N N     . ASP A 1 499 ? 101.814 81.116  126.930 1.00 67.93  ? 499 ASP A N     1 
ATOM 3491 C CA    . ASP A 1 499 ? 100.764 80.158  127.257 1.00 69.46  ? 499 ASP A CA    1 
ATOM 3492 C C     . ASP A 1 499 ? 100.287 80.330  128.693 1.00 68.21  ? 499 ASP A C     1 
ATOM 3493 O O     . ASP A 1 499 ? 99.111  80.627  128.931 1.00 69.04  ? 499 ASP A O     1 
ATOM 3494 C CB    . ASP A 1 499 ? 101.256 78.725  127.032 1.00 72.25  ? 499 ASP A CB    1 
ATOM 3495 C CG    . ASP A 1 499 ? 100.220 77.683  127.418 1.00 70.40  ? 499 ASP A CG    1 
ATOM 3496 O OD1   . ASP A 1 499 ? 99.055  77.804  126.987 1.00 70.25  ? 499 ASP A OD1   1 
ATOM 3497 O OD2   . ASP A 1 499 ? 100.571 76.737  128.153 1.00 68.54  ? 499 ASP A OD2   1 
ATOM 3498 N N     . SER A 1 500 ? 101.190 80.149  129.651 1.00 64.75  ? 500 SER A N     1 
ATOM 3499 C CA    . SER A 1 500 ? 100.859 80.227  131.071 1.00 67.49  ? 500 SER A CA    1 
ATOM 3500 C C     . SER A 1 500 ? 101.268 81.550  131.703 1.00 65.78  ? 500 SER A C     1 
ATOM 3501 O O     . SER A 1 500 ? 102.241 81.596  132.457 1.00 68.61  ? 500 SER A O     1 
ATOM 3502 C CB    . SER A 1 500 ? 101.501 79.055  131.801 1.00 70.70  ? 500 SER A CB    1 
ATOM 3503 O OG    . SER A 1 500 ? 101.089 77.821  131.247 1.00 67.51  ? 500 SER A OG    1 
ATOM 3504 N N     . VAL A 1 501 ? 100.574 82.652  131.405 1.00 60.35  ? 501 VAL A N     1 
ATOM 3505 C CA    . VAL A 1 501 ? 100.929 83.925  132.028 1.00 58.39  ? 501 VAL A CA    1 
ATOM 3506 C C     . VAL A 1 501 ? 100.000 84.226  133.199 1.00 54.94  ? 501 VAL A C     1 
ATOM 3507 O O     . VAL A 1 501 ? 100.365 84.953  134.130 1.00 47.21  ? 501 VAL A O     1 
ATOM 3508 C CB    . VAL A 1 501 ? 100.935 85.059  130.977 1.00 57.76  ? 501 VAL A CB    1 
ATOM 3509 C CG1   . VAL A 1 501 ? 101.603 84.592  129.702 1.00 60.86  ? 501 VAL A CG1   1 
ATOM 3510 C CG2   . VAL A 1 501 ? 99.551  85.630  130.684 1.00 55.72  ? 501 VAL A CG2   1 
ATOM 3511 N N     . GLU A 1 502 ? 98.798  83.660  133.182 1.00 65.07  ? 502 GLU A N     1 
ATOM 3512 C CA    . GLU A 1 502 ? 97.729  84.068  134.085 1.00 67.36  ? 502 GLU A CA    1 
ATOM 3513 C C     . GLU A 1 502 ? 97.748  83.459  135.494 1.00 68.39  ? 502 GLU A C     1 
ATOM 3514 O O     . GLU A 1 502 ? 97.493  84.223  136.436 1.00 66.19  ? 502 GLU A O     1 
ATOM 3515 C CB    . GLU A 1 502 ? 96.369  83.825  133.411 1.00 63.86  ? 502 GLU A CB    1 
ATOM 3516 C CG    . GLU A 1 502 ? 95.872  84.976  132.536 1.00 60.57  ? 502 GLU A CG    1 
ATOM 3517 C CD    . GLU A 1 502 ? 95.268  86.133  133.320 1.00 61.89  ? 502 GLU A CD    1 
ATOM 3518 O OE1   . GLU A 1 502 ? 95.173  86.049  134.562 1.00 67.02  ? 502 GLU A OE1   1 
ATOM 3519 O OE2   . GLU A 1 502 ? 94.883  87.138  132.685 1.00 58.89  ? 502 GLU A OE2   1 
ATOM 3520 N N     . PRO A 1 503 ? 97.983  82.136  135.721 1.00 64.21  ? 503 PRO A N     1 
ATOM 3521 C CA    . PRO A 1 503 ? 97.963  81.650  137.119 1.00 63.31  ? 503 PRO A CA    1 
ATOM 3522 C C     . PRO A 1 503 ? 99.062  82.206  138.013 1.00 59.53  ? 503 PRO A C     1 
ATOM 3523 O O     . PRO A 1 503 ? 98.809  82.466  139.194 1.00 59.71  ? 503 PRO A O     1 
ATOM 3524 C CB    . PRO A 1 503 ? 98.081  80.128  136.961 1.00 57.71  ? 503 PRO A CB    1 
ATOM 3525 C CG    . PRO A 1 503 ? 97.559  79.845  135.637 1.00 58.38  ? 503 PRO A CG    1 
ATOM 3526 C CD    . PRO A 1 503 ? 98.053  80.971  134.806 1.00 57.49  ? 503 PRO A CD    1 
ATOM 3527 N N     . MET A 1 504 ? 100.261 82.443  137.479 1.00 51.48  ? 504 MET A N     1 
ATOM 3528 C CA    . MET A 1 504 ? 101.298 83.047  138.308 1.00 55.64  ? 504 MET A CA    1 
ATOM 3529 C C     . MET A 1 504 ? 101.054 84.530  138.561 1.00 62.76  ? 504 MET A C     1 
ATOM 3530 O O     . MET A 1 504 ? 101.431 85.033  139.624 1.00 64.77  ? 504 MET A O     1 
ATOM 3531 C CB    . MET A 1 504 ? 102.677 82.818  137.699 1.00 58.51  ? 504 MET A CB    1 
ATOM 3532 C CG    . MET A 1 504 ? 102.899 81.426  137.154 1.00 57.59  ? 504 MET A CG    1 
ATOM 3533 S SD    . MET A 1 504 ? 101.937 80.933  135.727 1.00 63.01  ? 504 MET A SD    1 
ATOM 3534 C CE    . MET A 1 504 ? 103.059 79.703  135.073 1.00 57.27  ? 504 MET A CE    1 
ATOM 3535 N N     . PHE A 1 505 ? 100.414 85.240  137.628 1.00 61.89  ? 505 PHE A N     1 
ATOM 3536 C CA    . PHE A 1 505 ? 100.043 86.630  137.893 1.00 62.35  ? 505 PHE A CA    1 
ATOM 3537 C C     . PHE A 1 505 ? 98.941  86.713  138.943 1.00 61.69  ? 505 PHE A C     1 
ATOM 3538 O O     . PHE A 1 505 ? 98.959  87.601  139.805 1.00 58.52  ? 505 PHE A O     1 
ATOM 3539 C CB    . PHE A 1 505 ? 99.616  87.330  136.603 1.00 61.44  ? 505 PHE A CB    1 
ATOM 3540 C CG    . PHE A 1 505 ? 100.671 88.227  136.023 1.00 63.57  ? 505 PHE A CG    1 
ATOM 3541 C CD1   . PHE A 1 505 ? 102.000 87.832  135.997 1.00 62.25  ? 505 PHE A CD1   1 
ATOM 3542 C CD2   . PHE A 1 505 ? 100.332 89.467  135.497 1.00 58.17  ? 505 PHE A CD2   1 
ATOM 3543 C CE1   . PHE A 1 505 ? 102.975 88.660  135.460 1.00 52.39  ? 505 PHE A CE1   1 
ATOM 3544 C CE2   . PHE A 1 505 ? 101.298 90.300  134.958 1.00 53.01  ? 505 PHE A CE2   1 
ATOM 3545 C CZ    . PHE A 1 505 ? 102.620 89.896  134.944 1.00 47.65  ? 505 PHE A CZ    1 
ATOM 3546 N N     . ARG A 1 506 ? 97.983  85.777  138.895 1.00 62.36  ? 506 ARG A N     1 
ATOM 3547 C CA    . ARG A 1 506 ? 96.983  85.669  139.957 1.00 64.72  ? 506 ARG A CA    1 
ATOM 3548 C C     . ARG A 1 506 ? 97.627  85.314  141.292 1.00 63.83  ? 506 ARG A C     1 
ATOM 3549 O O     . ARG A 1 506 ? 97.210  85.815  142.343 1.00 62.94  ? 506 ARG A O     1 
ATOM 3550 C CB    . ARG A 1 506 ? 95.932  84.623  139.590 1.00 65.43  ? 506 ARG A CB    1 
ATOM 3551 C CG    . ARG A 1 506 ? 95.029  84.991  138.433 1.00 62.79  ? 506 ARG A CG    1 
ATOM 3552 C CD    . ARG A 1 506 ? 93.986  86.021  138.833 1.00 63.79  ? 506 ARG A CD    1 
ATOM 3553 N NE    . ARG A 1 506 ? 92.812  85.992  137.966 1.00 65.64  ? 506 ARG A NE    1 
ATOM 3554 C CZ    . ARG A 1 506 ? 92.769  86.454  136.723 1.00 65.99  ? 506 ARG A CZ    1 
ATOM 3555 N NH1   . ARG A 1 506 ? 93.796  87.084  136.181 1.00 66.52  ? 506 ARG A NH1   1 
ATOM 3556 N NH2   . ARG A 1 506 ? 91.653  86.304  136.014 1.00 66.35  ? 506 ARG A NH2   1 
ATOM 3557 N N     . HIS A 1 507 ? 98.645  84.450  141.261 1.00 61.66  ? 507 HIS A N     1 
ATOM 3558 C CA    . HIS A 1 507 ? 99.371  84.082  142.471 1.00 64.22  ? 507 HIS A CA    1 
ATOM 3559 C C     . HIS A 1 507 ? 100.134 85.267  143.050 1.00 68.06  ? 507 HIS A C     1 
ATOM 3560 O O     . HIS A 1 507 ? 100.200 85.432  144.271 1.00 69.27  ? 507 HIS A O     1 
ATOM 3561 C CB    . HIS A 1 507 ? 100.319 82.925  142.165 1.00 65.16  ? 507 HIS A CB    1 
ATOM 3562 C CG    . HIS A 1 507 ? 101.522 82.878  143.051 1.00 68.18  ? 507 HIS A CG    1 
ATOM 3563 N ND1   . HIS A 1 507 ? 101.474 82.409  144.346 1.00 69.60  ? 507 HIS A ND1   1 
ATOM 3564 C CD2   . HIS A 1 507 ? 102.810 83.230  142.825 1.00 59.85  ? 507 HIS A CD2   1 
ATOM 3565 C CE1   . HIS A 1 507 ? 102.679 82.482  144.882 1.00 70.02  ? 507 HIS A CE1   1 
ATOM 3566 N NE2   . HIS A 1 507 ? 103.507 82.977  143.980 1.00 63.15  ? 507 HIS A NE2   1 
ATOM 3567 N N     . LEU A 1 508 ? 100.712 86.104  142.187 1.00 63.96  ? 508 LEU A N     1 
ATOM 3568 C CA    . LEU A 1 508 ? 101.426 87.289  142.654 1.00 61.84  ? 508 LEU A CA    1 
ATOM 3569 C C     . LEU A 1 508 ? 100.470 88.350  143.186 1.00 56.54  ? 508 LEU A C     1 
ATOM 3570 O O     . LEU A 1 508 ? 100.816 89.090  144.113 1.00 52.73  ? 508 LEU A O     1 
ATOM 3571 C CB    . LEU A 1 508 ? 102.276 87.868  141.529 1.00 59.33  ? 508 LEU A CB    1 
ATOM 3572 C CG    . LEU A 1 508 ? 103.751 87.494  141.512 1.00 55.49  ? 508 LEU A CG    1 
ATOM 3573 C CD1   . LEU A 1 508 ? 104.429 88.307  140.442 1.00 56.42  ? 508 LEU A CD1   1 
ATOM 3574 C CD2   . LEU A 1 508 ? 104.391 87.733  142.867 1.00 50.72  ? 508 LEU A CD2   1 
ATOM 3575 N N     . LYS A 1 509 ? 99.276  88.459  142.596 1.00 59.47  ? 509 LYS A N     1 
ATOM 3576 C CA    . LYS A 1 509 ? 98.303  89.429  143.087 1.00 57.54  ? 509 LYS A CA    1 
ATOM 3577 C C     . LYS A 1 509 ? 97.703  88.993  144.420 1.00 65.52  ? 509 LYS A C     1 
ATOM 3578 O O     . LYS A 1 509 ? 97.545  89.812  145.334 1.00 64.44  ? 509 LYS A O     1 
ATOM 3579 C CB    . LYS A 1 509 ? 97.203  89.642  142.050 1.00 59.73  ? 509 LYS A CB    1 
ATOM 3580 C CG    . LYS A 1 509 ? 96.214  90.739  142.404 1.00 63.32  ? 509 LYS A CG    1 
ATOM 3581 C CD    . LYS A 1 509 ? 96.883  92.100  142.448 1.00 64.93  ? 509 LYS A CD    1 
ATOM 3582 C CE    . LYS A 1 509 ? 95.857  93.212  142.593 1.00 64.14  ? 509 LYS A CE    1 
ATOM 3583 N NZ    . LYS A 1 509 ? 95.004  93.362  141.383 1.00 66.57  ? 509 LYS A NZ    1 
ATOM 3584 N N     . ASN A 1 510 ? 97.367  87.707  144.559 1.00 70.69  ? 510 ASN A N     1 
ATOM 3585 C CA    . ASN A 1 510 ? 96.683  87.262  145.768 1.00 65.02  ? 510 ASN A CA    1 
ATOM 3586 C C     . ASN A 1 510 ? 97.645  86.877  146.884 1.00 65.48  ? 510 ASN A C     1 
ATOM 3587 O O     . ASN A 1 510 ? 97.262  86.908  148.059 1.00 70.34  ? 510 ASN A O     1 
ATOM 3588 C CB    . ASN A 1 510 ? 95.761  86.084  145.449 1.00 62.77  ? 510 ASN A CB    1 
ATOM 3589 C CG    . ASN A 1 510 ? 94.699  86.435  144.428 1.00 65.48  ? 510 ASN A CG    1 
ATOM 3590 O OD1   . ASN A 1 510 ? 94.514  85.730  143.438 1.00 65.92  ? 510 ASN A OD1   1 
ATOM 3591 N ND2   . ASN A 1 510 ? 94.002  87.541  144.659 1.00 66.47  ? 510 ASN A ND2   1 
ATOM 3592 N N     . THR A 1 511 ? 98.886  86.523  146.553 1.00 61.06  ? 511 THR A N     1 
ATOM 3593 C CA    . THR A 1 511 ? 99.830  86.051  147.560 1.00 62.34  ? 511 THR A CA    1 
ATOM 3594 C C     . THR A 1 511 ? 100.476 87.214  148.302 1.00 62.99  ? 511 THR A C     1 
ATOM 3595 O O     . THR A 1 511 ? 100.338 87.342  149.523 1.00 61.07  ? 511 THR A O     1 
ATOM 3596 C CB    . THR A 1 511 ? 100.905 85.181  146.904 1.00 59.18  ? 511 THR A CB    1 
ATOM 3597 O OG1   . THR A 1 511 ? 100.284 84.094  146.208 1.00 57.42  ? 511 THR A OG1   1 
ATOM 3598 C CG2   . THR A 1 511 ? 101.854 84.630  147.951 1.00 59.83  ? 511 THR A CG2   1 
ATOM 3599 N N     . TYR A 1 512 ? 101.185 88.070  147.573 1.00 66.84  ? 512 TYR A N     1 
ATOM 3600 C CA    . TYR A 1 512 ? 101.920 89.191  148.151 1.00 68.46  ? 512 TYR A CA    1 
ATOM 3601 C C     . TYR A 1 512 ? 101.037 90.428  148.059 1.00 62.75  ? 512 TYR A C     1 
ATOM 3602 O O     . TYR A 1 512 ? 100.898 91.029  146.991 1.00 60.89  ? 512 TYR A O     1 
ATOM 3603 C CB    . TYR A 1 512 ? 103.254 89.380  147.439 1.00 64.07  ? 512 TYR A CB    1 
ATOM 3604 C CG    . TYR A 1 512 ? 104.185 88.204  147.619 1.00 65.80  ? 512 TYR A CG    1 
ATOM 3605 C CD1   . TYR A 1 512 ? 105.022 88.125  148.728 1.00 66.40  ? 512 TYR A CD1   1 
ATOM 3606 C CD2   . TYR A 1 512 ? 104.211 87.160  146.698 1.00 60.64  ? 512 TYR A CD2   1 
ATOM 3607 C CE1   . TYR A 1 512 ? 105.870 87.045  148.909 1.00 64.99  ? 512 TYR A CE1   1 
ATOM 3608 C CE2   . TYR A 1 512 ? 105.056 86.075  146.871 1.00 61.49  ? 512 TYR A CE2   1 
ATOM 3609 C CZ    . TYR A 1 512 ? 105.882 86.026  147.977 1.00 64.63  ? 512 TYR A CZ    1 
ATOM 3610 O OH    . TYR A 1 512 ? 106.725 84.954  148.156 1.00 62.59  ? 512 TYR A OH    1 
ATOM 3611 N N     . ALA A 1 513 ? 100.431 90.796  149.186 1.00 47.27  ? 513 ALA A N     1 
ATOM 3612 C CA    . ALA A 1 513 ? 99.517  91.926  149.216 1.00 47.29  ? 513 ALA A CA    1 
ATOM 3613 C C     . ALA A 1 513 ? 100.280 93.237  149.089 1.00 45.05  ? 513 ALA A C     1 
ATOM 3614 O O     . ALA A 1 513 ? 101.342 93.417  149.691 1.00 48.62  ? 513 ALA A O     1 
ATOM 3615 C CB    . ALA A 1 513 ? 98.703  91.912  150.510 1.00 50.00  ? 513 ALA A CB    1 
ATOM 3616 N N     . GLY A 1 514 ? 99.721  94.159  148.309 1.00 40.65  ? 514 GLY A N     1 
ATOM 3617 C CA    . GLY A 1 514 ? 100.367 95.427  148.046 1.00 45.21  ? 514 GLY A CA    1 
ATOM 3618 C C     . GLY A 1 514 ? 101.634 95.304  147.226 1.00 44.98  ? 514 GLY A C     1 
ATOM 3619 O O     . GLY A 1 514 ? 102.662 95.890  147.579 1.00 39.15  ? 514 GLY A O     1 
ATOM 3620 N N     . LEU A 1 515 ? 101.584 94.515  146.153 1.00 40.79  ? 515 LEU A N     1 
ATOM 3621 C CA    . LEU A 1 515 ? 102.728 94.388  145.261 1.00 40.43  ? 515 LEU A CA    1 
ATOM 3622 C C     . LEU A 1 515 ? 102.943 95.688  144.496 1.00 43.47  ? 515 LEU A C     1 
ATOM 3623 O O     . LEU A 1 515 ? 101.993 96.308  144.010 1.00 41.64  ? 515 LEU A O     1 
ATOM 3624 C CB    . LEU A 1 515 ? 102.527 93.228  144.287 1.00 33.37  ? 515 LEU A CB    1 
ATOM 3625 C CG    . LEU A 1 515 ? 103.787 92.648  143.640 1.00 33.22  ? 515 LEU A CG    1 
ATOM 3626 C CD1   . LEU A 1 515 ? 104.854 92.361  144.680 1.00 33.70  ? 515 LEU A CD1   1 
ATOM 3627 C CD2   . LEU A 1 515 ? 103.461 91.396  142.859 1.00 46.39  ? 515 LEU A CD2   1 
ATOM 3628 N N     . GLN A 1 516 ? 104.208 96.098  144.390 1.00 48.88  ? 516 GLN A N     1 
ATOM 3629 C CA    . GLN A 1 516 ? 104.540 97.443  143.931 1.00 44.92  ? 516 GLN A CA    1 
ATOM 3630 C C     . GLN A 1 516 ? 104.988 97.458  142.471 1.00 42.37  ? 516 GLN A C     1 
ATOM 3631 O O     . GLN A 1 516 ? 104.517 98.281  141.681 1.00 46.02  ? 516 GLN A O     1 
ATOM 3632 C CB    . GLN A 1 516 ? 105.613 98.038  144.849 1.00 38.00  ? 516 GLN A CB    1 
ATOM 3633 C CG    . GLN A 1 516 ? 105.025 98.784  146.038 1.00 42.99  ? 516 GLN A CG    1 
ATOM 3634 C CD    . GLN A 1 516 ? 106.038 99.630  146.772 1.00 37.36  ? 516 GLN A CD    1 
ATOM 3635 O OE1   . GLN A 1 516 ? 106.879 99.108  147.501 1.00 37.40  ? 516 GLN A OE1   1 
ATOM 3636 N NE2   . GLN A 1 516 ? 105.953 100.944 146.601 1.00 37.89  ? 516 GLN A NE2   1 
ATOM 3637 N N     . LEU A 1 517 ? 105.892 96.557  142.100 1.00 42.12  ? 517 LEU A N     1 
ATOM 3638 C CA    . LEU A 1 517 ? 106.389 96.501  140.735 1.00 42.58  ? 517 LEU A CA    1 
ATOM 3639 C C     . LEU A 1 517 ? 106.736 95.058  140.396 1.00 49.61  ? 517 LEU A C     1 
ATOM 3640 O O     . LEU A 1 517 ? 107.180 94.295  141.255 1.00 57.75  ? 517 LEU A O     1 
ATOM 3641 C CB    . LEU A 1 517 ? 107.608 97.429  140.563 1.00 40.05  ? 517 LEU A CB    1 
ATOM 3642 C CG    . LEU A 1 517 ? 108.544 97.301  139.360 1.00 43.01  ? 517 LEU A CG    1 
ATOM 3643 C CD1   . LEU A 1 517 ? 107.851 97.860  138.140 1.00 46.04  ? 517 LEU A CD1   1 
ATOM 3644 C CD2   . LEU A 1 517 ? 109.862 98.006  139.596 1.00 48.31  ? 517 LEU A CD2   1 
ATOM 3645 N N     . VAL A 1 518 ? 106.504 94.676  139.145 1.00 49.31  ? 518 VAL A N     1 
ATOM 3646 C CA    . VAL A 1 518 ? 106.910 93.370  138.646 1.00 47.80  ? 518 VAL A CA    1 
ATOM 3647 C C     . VAL A 1 518 ? 107.903 93.564  137.508 1.00 52.52  ? 518 VAL A C     1 
ATOM 3648 O O     . VAL A 1 518 ? 107.686 94.390  136.612 1.00 50.60  ? 518 VAL A O     1 
ATOM 3649 C CB    . VAL A 1 518 ? 105.708 92.522  138.212 1.00 44.76  ? 518 VAL A CB    1 
ATOM 3650 C CG1   . VAL A 1 518 ? 105.112 91.847  139.418 1.00 43.02  ? 518 VAL A CG1   1 
ATOM 3651 C CG2   . VAL A 1 518 ? 104.659 93.404  137.594 1.00 40.97  ? 518 VAL A CG2   1 
ATOM 3652 N N     . VAL A 1 519 ? 108.999 92.811  137.560 1.00 49.75  ? 519 VAL A N     1 
ATOM 3653 C CA    . VAL A 1 519 ? 110.071 92.871  136.575 1.00 48.54  ? 519 VAL A CA    1 
ATOM 3654 C C     . VAL A 1 519 ? 109.901 91.699  135.618 1.00 59.25  ? 519 VAL A C     1 
ATOM 3655 O O     . VAL A 1 519 ? 109.783 90.548  136.053 1.00 62.44  ? 519 VAL A O     1 
ATOM 3656 C CB    . VAL A 1 519 ? 111.447 92.835  137.262 1.00 44.79  ? 519 VAL A CB    1 
ATOM 3657 C CG1   . VAL A 1 519 ? 112.559 92.691  136.249 1.00 46.36  ? 519 VAL A CG1   1 
ATOM 3658 C CG2   . VAL A 1 519 ? 111.651 94.084  138.078 1.00 48.22  ? 519 VAL A CG2   1 
ATOM 3659 N N     . VAL A 1 520 ? 109.872 91.984  134.319 1.00 40.21  ? 520 VAL A N     1 
ATOM 3660 C CA    . VAL A 1 520 ? 109.636 90.969  133.303 1.00 29.54  ? 520 VAL A CA    1 
ATOM 3661 C C     . VAL A 1 520 ? 110.821 91.005  132.350 1.00 24.34  ? 520 VAL A C     1 
ATOM 3662 O O     . VAL A 1 520 ? 111.211 92.077  131.889 1.00 30.44  ? 520 VAL A O     1 
ATOM 3663 C CB    . VAL A 1 520 ? 108.304 91.223  132.565 1.00 26.57  ? 520 VAL A CB    1 
ATOM 3664 C CG1   . VAL A 1 520 ? 108.309 90.680  131.148 1.00 29.11  ? 520 VAL A CG1   1 
ATOM 3665 C CG2   . VAL A 1 520 ? 107.127 90.695  133.363 1.00 43.39  ? 520 VAL A CG2   1 
ATOM 3666 N N     . ILE A 1 521 ? 111.426 89.857  132.084 1.00 31.69  ? 521 ILE A N     1 
ATOM 3667 C CA    . ILE A 1 521 ? 112.568 89.782  131.177 1.00 31.53  ? 521 ILE A CA    1 
ATOM 3668 C C     . ILE A 1 521 ? 112.119 89.057  129.913 1.00 36.06  ? 521 ILE A C     1 
ATOM 3669 O O     . ILE A 1 521 ? 111.438 88.029  129.994 1.00 50.75  ? 521 ILE A O     1 
ATOM 3670 C CB    . ILE A 1 521 ? 113.773 89.095  131.838 1.00 33.61  ? 521 ILE A CB    1 
ATOM 3671 C CG1   . ILE A 1 521 ? 114.013 89.664  133.242 1.00 35.61  ? 521 ILE A CG1   1 
ATOM 3672 C CG2   . ILE A 1 521 ? 115.017 89.221  130.970 1.00 28.93  ? 521 ILE A CG2   1 
ATOM 3673 C CD1   . ILE A 1 521 ? 114.355 91.126  133.278 1.00 22.04  ? 521 ILE A CD1   1 
ATOM 3674 N N     . LEU A 1 522 ? 112.469 89.605  128.746 1.00 27.96  ? 522 LEU A N     1 
ATOM 3675 C CA    . LEU A 1 522 ? 111.955 89.162  127.454 1.00 31.70  ? 522 LEU A CA    1 
ATOM 3676 C C     . LEU A 1 522 ? 113.076 88.847  126.473 1.00 40.65  ? 522 LEU A C     1 
ATOM 3677 O O     . LEU A 1 522 ? 114.123 89.500  126.491 1.00 47.10  ? 522 LEU A O     1 
ATOM 3678 C CB    . LEU A 1 522 ? 111.077 90.251  126.836 1.00 31.26  ? 522 LEU A CB    1 
ATOM 3679 C CG    . LEU A 1 522 ? 110.003 90.823  127.726 1.00 33.29  ? 522 LEU A CG    1 
ATOM 3680 C CD1   . LEU A 1 522 ? 109.871 92.263  127.357 1.00 31.70  ? 522 LEU A CD1   1 
ATOM 3681 C CD2   . LEU A 1 522 ? 108.730 90.057  127.513 1.00 35.85  ? 522 LEU A CD2   1 
ATOM 3682 N N     . PRO A 1 523 ? 112.873 87.881  125.548 1.00 45.50  ? 523 PRO A N     1 
ATOM 3683 C CA    . PRO A 1 523 ? 113.941 87.567  124.588 1.00 46.45  ? 523 PRO A CA    1 
ATOM 3684 C C     . PRO A 1 523 ? 114.078 88.596  123.469 1.00 51.46  ? 523 PRO A C     1 
ATOM 3685 O O     . PRO A 1 523 ? 115.197 88.898  123.038 1.00 48.05  ? 523 PRO A O     1 
ATOM 3686 C CB    . PRO A 1 523 ? 113.532 86.191  124.048 1.00 42.06  ? 523 PRO A CB    1 
ATOM 3687 C CG    . PRO A 1 523 ? 112.062 86.146  124.200 1.00 42.11  ? 523 PRO A CG    1 
ATOM 3688 C CD    . PRO A 1 523 ? 111.718 86.974  125.400 1.00 42.28  ? 523 PRO A CD    1 
ATOM 3689 N N     . GLY A 1 524 ? 112.960 89.152  123.006 1.00 56.82  ? 524 GLY A N     1 
ATOM 3690 C CA    . GLY A 1 524 ? 112.973 90.095  121.903 1.00 52.60  ? 524 GLY A CA    1 
ATOM 3691 C C     . GLY A 1 524 ? 111.580 90.539  121.506 1.00 54.18  ? 524 GLY A C     1 
ATOM 3692 O O     . GLY A 1 524 ? 110.741 90.785  122.376 1.00 54.58  ? 524 GLY A O     1 
ATOM 3693 N N     . LYS A 1 525 ? 111.321 90.657  120.198 1.00 56.06  ? 525 LYS A N     1 
ATOM 3694 C CA    . LYS A 1 525 ? 109.987 90.964  119.685 1.00 56.22  ? 525 LYS A CA    1 
ATOM 3695 C C     . LYS A 1 525 ? 109.230 89.640  119.520 1.00 57.17  ? 525 LYS A C     1 
ATOM 3696 O O     . LYS A 1 525 ? 109.556 88.799  118.672 1.00 60.86  ? 525 LYS A O     1 
ATOM 3697 C CB    . LYS A 1 525 ? 110.055 91.831  118.419 1.00 54.57  ? 525 LYS A CB    1 
ATOM 3698 C CG    . LYS A 1 525 ? 110.775 91.291  117.171 1.00 54.90  ? 525 LYS A CG    1 
ATOM 3699 C CD    . LYS A 1 525 ? 110.575 92.207  115.978 1.00 56.70  ? 525 LYS A CD    1 
ATOM 3700 C CE    . LYS A 1 525 ? 109.472 91.660  115.074 1.00 59.61  ? 525 LYS A CE    1 
ATOM 3701 N NZ    . LYS A 1 525 ? 109.736 90.280  114.587 1.00 55.73  ? 525 LYS A NZ    1 
ATOM 3702 N N     . THR A 1 526 ? 108.254 89.437  120.399 1.00 50.11  ? 526 THR A N     1 
ATOM 3703 C CA    . THR A 1 526 ? 107.544 88.181  120.585 1.00 56.48  ? 526 THR A CA    1 
ATOM 3704 C C     . THR A 1 526 ? 106.264 88.494  121.343 1.00 50.96  ? 526 THR A C     1 
ATOM 3705 O O     . THR A 1 526 ? 106.259 89.356  122.229 1.00 50.03  ? 526 THR A O     1 
ATOM 3706 C CB    . THR A 1 526 ? 108.425 87.160  121.325 1.00 55.91  ? 526 THR A CB    1 
ATOM 3707 O OG1   . THR A 1 526 ? 107.682 85.990  121.684 1.00 57.82  ? 526 THR A OG1   1 
ATOM 3708 C CG2   . THR A 1 526 ? 109.127 87.775  122.547 1.00 44.67  ? 526 THR A CG2   1 
ATOM 3709 N N     . PRO A 1 527 ? 105.147 87.849  121.003 1.00 48.52  ? 527 PRO A N     1 
ATOM 3710 C CA    . PRO A 1 527 ? 103.889 88.191  121.691 1.00 45.28  ? 527 PRO A CA    1 
ATOM 3711 C C     . PRO A 1 527 ? 103.642 87.621  123.097 1.00 45.19  ? 527 PRO A C     1 
ATOM 3712 O O     . PRO A 1 527 ? 102.513 87.774  123.596 1.00 47.66  ? 527 PRO A O     1 
ATOM 3713 C CB    . PRO A 1 527 ? 102.854 87.742  120.617 1.00 50.30  ? 527 PRO A CB    1 
ATOM 3714 C CG    . PRO A 1 527 ? 103.817 87.123  120.297 1.00 53.28  ? 527 PRO A CG    1 
ATOM 3715 C CD    . PRO A 1 527 ? 104.652 86.441  120.661 1.00 52.41  ? 527 PRO A CD    1 
ATOM 3716 N N     . VAL A 1 528 ? 104.655 87.088  123.786 1.00 49.23  ? 528 VAL A N     1 
ATOM 3717 C CA    . VAL A 1 528 ? 104.568 86.911  125.228 1.00 57.88  ? 528 VAL A CA    1 
ATOM 3718 C C     . VAL A 1 528 ? 104.673 88.264  125.911 1.00 47.71  ? 528 VAL A C     1 
ATOM 3719 O O     . VAL A 1 528 ? 104.002 88.519  126.917 1.00 44.28  ? 528 VAL A O     1 
ATOM 3720 C CB    . VAL A 1 528 ? 105.637 85.892  125.689 1.00 58.72  ? 528 VAL A CB    1 
ATOM 3721 C CG1   . VAL A 1 528 ? 107.016 86.251  125.183 1.00 53.72  ? 528 VAL A CG1   1 
ATOM 3722 C CG2   . VAL A 1 528 ? 105.639 85.732  127.186 1.00 51.16  ? 528 VAL A CG2   1 
ATOM 3723 N N     . TYR A 1 529 ? 105.442 89.183  125.309 1.00 45.20  ? 529 TYR A N     1 
ATOM 3724 C CA    . TYR A 1 529 ? 105.438 90.583  125.720 1.00 38.68  ? 529 TYR A CA    1 
ATOM 3725 C C     . TYR A 1 529 ? 104.070 91.213  125.513 1.00 37.56  ? 529 TYR A C     1 
ATOM 3726 O O     . TYR A 1 529 ? 103.576 91.947  126.380 1.00 44.60  ? 529 TYR A O     1 
ATOM 3727 C CB    . TYR A 1 529 ? 106.494 91.346  124.921 1.00 29.39  ? 529 TYR A CB    1 
ATOM 3728 C CG    . TYR A 1 529 ? 106.851 92.714  125.447 1.00 31.66  ? 529 TYR A CG    1 
ATOM 3729 C CD1   . TYR A 1 529 ? 106.495 93.122  126.728 1.00 38.90  ? 529 TYR A CD1   1 
ATOM 3730 C CD2   . TYR A 1 529 ? 107.577 93.594  124.665 1.00 45.00  ? 529 TYR A CD2   1 
ATOM 3731 C CE1   . TYR A 1 529 ? 106.827 94.354  127.188 1.00 43.67  ? 529 TYR A CE1   1 
ATOM 3732 C CE2   . TYR A 1 529 ? 107.909 94.831  125.127 1.00 43.55  ? 529 TYR A CE2   1 
ATOM 3733 C CZ    . TYR A 1 529 ? 107.536 95.202  126.389 1.00 45.73  ? 529 TYR A CZ    1 
ATOM 3734 O OH    . TYR A 1 529 ? 107.868 96.434  126.872 1.00 41.54  ? 529 TYR A OH    1 
ATOM 3735 N N     . ALA A 1 530 ? 103.459 90.932  124.365 1.00 49.95  ? 530 ALA A N     1 
ATOM 3736 C CA    . ALA A 1 530 ? 102.135 91.432  124.047 1.00 47.72  ? 530 ALA A CA    1 
ATOM 3737 C C     . ALA A 1 530 ? 101.094 90.957  125.044 1.00 45.09  ? 530 ALA A C     1 
ATOM 3738 O O     . ALA A 1 530 ? 100.316 91.770  125.571 1.00 47.63  ? 530 ALA A O     1 
ATOM 3739 C CB    . ALA A 1 530 ? 101.756 90.971  122.646 1.00 51.70  ? 530 ALA A CB    1 
ATOM 3740 N N     . GLU A 1 531 ? 101.107 89.663  125.355 1.00 45.69  ? 531 GLU A N     1 
ATOM 3741 C CA    . GLU A 1 531 ? 100.183 89.090  126.320 1.00 48.37  ? 531 GLU A CA    1 
ATOM 3742 C C     . GLU A 1 531 ? 100.428 89.583  127.742 1.00 49.90  ? 531 GLU A C     1 
ATOM 3743 O O     . GLU A 1 531 ? 99.457  89.872  128.452 1.00 46.89  ? 531 GLU A O     1 
ATOM 3744 C CB    . GLU A 1 531 ? 100.259 87.562  126.260 1.00 51.69  ? 531 GLU A CB    1 
ATOM 3745 C CG    . GLU A 1 531 ? 99.340  86.831  127.220 1.00 52.52  ? 531 GLU A CG    1 
ATOM 3746 C CD    . GLU A 1 531 ? 97.867  86.992  126.887 1.00 54.85  ? 531 GLU A CD    1 
ATOM 3747 O OE1   . GLU A 1 531 ? 97.529  87.241  125.711 1.00 51.01  ? 531 GLU A OE1   1 
ATOM 3748 O OE2   . GLU A 1 531 ? 97.038  86.859  127.808 1.00 54.78  ? 531 GLU A OE2   1 
ATOM 3749 N N     . VAL A 1 532 ? 101.693 89.722  128.166 1.00 53.96  ? 532 VAL A N     1 
ATOM 3750 C CA    . VAL A 1 532 ? 101.961 90.181  129.529 1.00 48.15  ? 532 VAL A CA    1 
ATOM 3751 C C     . VAL A 1 532 ? 101.609 91.659  129.683 1.00 35.43  ? 532 VAL A C     1 
ATOM 3752 O O     . VAL A 1 532 ? 101.128 92.068  130.743 1.00 38.14  ? 532 VAL A O     1 
ATOM 3753 C CB    . VAL A 1 532 ? 103.413 89.865  129.967 1.00 44.27  ? 532 VAL A CB    1 
ATOM 3754 C CG1   . VAL A 1 532 ? 104.456 90.769  129.342 1.00 42.44  ? 532 VAL A CG1   1 
ATOM 3755 C CG2   . VAL A 1 532 ? 103.538 89.949  131.459 1.00 40.48  ? 532 VAL A CG2   1 
ATOM 3756 N N     . LYS A 1 533 ? 101.733 92.458  128.619 1.00 42.09  ? 533 LYS A N     1 
ATOM 3757 C CA    . LYS A 1 533 ? 101.357 93.860  128.720 1.00 45.26  ? 533 LYS A CA    1 
ATOM 3758 C C     . LYS A 1 533 ? 99.844  94.029  128.747 1.00 50.83  ? 533 LYS A C     1 
ATOM 3759 O O     . LYS A 1 533 ? 99.324  94.842  129.526 1.00 55.55  ? 533 LYS A O     1 
ATOM 3760 C CB    . LYS A 1 533 ? 101.975 94.648  127.572 1.00 41.18  ? 533 LYS A CB    1 
ATOM 3761 C CG    . LYS A 1 533 ? 102.048 96.121  127.847 1.00 36.86  ? 533 LYS A CG    1 
ATOM 3762 C CD    . LYS A 1 533 ? 102.849 96.431  129.107 1.00 42.20  ? 533 LYS A CD    1 
ATOM 3763 C CE    . LYS A 1 533 ? 104.313 96.059  129.000 1.00 42.22  ? 533 LYS A CE    1 
ATOM 3764 N NZ    . LYS A 1 533 ? 105.145 96.750  130.022 1.00 41.26  ? 533 LYS A NZ    1 
ATOM 3765 N N     . ARG A 1 534 ? 99.128  93.244  127.929 1.00 51.59  ? 534 ARG A N     1 
ATOM 3766 C CA    . ARG A 1 534 ? 97.667  93.270  127.958 1.00 47.09  ? 534 ARG A CA    1 
ATOM 3767 C C     . ARG A 1 534 ? 97.122  92.811  129.303 1.00 39.96  ? 534 ARG A C     1 
ATOM 3768 O O     . ARG A 1 534 ? 96.212  93.433  129.859 1.00 40.34  ? 534 ARG A O     1 
ATOM 3769 C CB    . ARG A 1 534 ? 97.091  92.410  126.835 1.00 49.50  ? 534 ARG A CB    1 
ATOM 3770 C CG    . ARG A 1 534 ? 95.569  92.481  126.755 1.00 46.41  ? 534 ARG A CG    1 
ATOM 3771 C CD    . ARG A 1 534 ? 94.971  91.152  126.330 1.00 43.64  ? 534 ARG A CD    1 
ATOM 3772 N NE    . ARG A 1 534 ? 94.844  90.214  127.439 1.00 48.27  ? 534 ARG A NE    1 
ATOM 3773 C CZ    . ARG A 1 534 ? 94.671  88.908  127.294 1.00 45.78  ? 534 ARG A CZ    1 
ATOM 3774 N NH1   . ARG A 1 534 ? 94.616  88.346  126.098 1.00 48.04  ? 534 ARG A NH1   1 
ATOM 3775 N NH2   . ARG A 1 534 ? 94.551  88.146  128.377 1.00 41.85  ? 534 ARG A NH2   1 
ATOM 3776 N N     . VAL A 1 535 ? 97.707  91.745  129.858 1.00 40.53  ? 535 VAL A N     1 
ATOM 3777 C CA    . VAL A 1 535 ? 97.255  91.225  131.145 1.00 47.60  ? 535 VAL A CA    1 
ATOM 3778 C C     . VAL A 1 535 ? 97.564  92.212  132.267 1.00 45.70  ? 535 VAL A C     1 
ATOM 3779 O O     . VAL A 1 535 ? 96.681  92.556  133.064 1.00 45.97  ? 535 VAL A O     1 
ATOM 3780 C CB    . VAL A 1 535 ? 97.873  89.834  131.389 1.00 53.45  ? 535 VAL A CB    1 
ATOM 3781 C CG1   . VAL A 1 535 ? 97.787  89.440  132.837 1.00 52.74  ? 535 VAL A CG1   1 
ATOM 3782 C CG2   . VAL A 1 535 ? 97.148  88.797  130.551 1.00 52.16  ? 535 VAL A CG2   1 
ATOM 3783 N N     . GLY A 1 536 ? 98.786  92.754  132.291 1.00 46.22  ? 536 GLY A N     1 
ATOM 3784 C CA    . GLY A 1 536 ? 99.199  93.679  133.325 1.00 43.01  ? 536 GLY A CA    1 
ATOM 3785 C C     . GLY A 1 536 ? 98.542  95.040  133.293 1.00 42.70  ? 536 GLY A C     1 
ATOM 3786 O O     . GLY A 1 536 ? 98.507  95.704  134.333 1.00 34.81  ? 536 GLY A O     1 
ATOM 3787 N N     . ASP A 1 537 ? 98.015  95.485  132.148 1.00 53.01  ? 537 ASP A N     1 
ATOM 3788 C CA    . ASP A 1 537 ? 97.286  96.744  132.147 1.00 49.00  ? 537 ASP A CA    1 
ATOM 3789 C C     . ASP A 1 537 ? 95.795  96.623  131.877 1.00 46.26  ? 537 ASP A C     1 
ATOM 3790 O O     . ASP A 1 537 ? 95.130  97.659  131.773 1.00 32.58  ? 537 ASP A O     1 
ATOM 3791 C CB    . ASP A 1 537 ? 97.880  97.721  131.128 1.00 39.22  ? 537 ASP A CB    1 
ATOM 3792 C CG    . ASP A 1 537 ? 99.376  97.732  131.153 1.00 30.96  ? 537 ASP A CG    1 
ATOM 3793 O OD1   . ASP A 1 537 ? 99.952  97.806  132.256 1.00 22.37  ? 537 ASP A OD1   1 
ATOM 3794 O OD2   . ASP A 1 537 ? 99.973  97.626  130.069 1.00 35.87  ? 537 ASP A OD2   1 
ATOM 3795 N N     . THR A 1 538 ? 95.248  95.415  131.739 1.00 55.93  ? 538 THR A N     1 
ATOM 3796 C CA    . THR A 1 538 ? 93.794  95.319  131.672 1.00 58.10  ? 538 THR A CA    1 
ATOM 3797 C C     . THR A 1 538 ? 93.205  94.394  132.725 1.00 62.18  ? 538 THR A C     1 
ATOM 3798 O O     . THR A 1 538 ? 92.168  94.721  133.305 1.00 59.15  ? 538 THR A O     1 
ATOM 3799 C CB    . THR A 1 538 ? 93.325  94.834  130.281 1.00 62.15  ? 538 THR A CB    1 
ATOM 3800 O OG1   . THR A 1 538 ? 93.920  93.564  129.984 1.00 59.79  ? 538 THR A OG1   1 
ATOM 3801 C CG2   . THR A 1 538 ? 93.674  95.840  129.187 1.00 62.59  ? 538 THR A CG2   1 
ATOM 3802 N N     . VAL A 1 539 ? 93.840  93.253  132.991 1.00 61.82  ? 539 VAL A N     1 
ATOM 3803 C CA    . VAL A 1 539 ? 93.153  92.171  133.690 1.00 62.59  ? 539 VAL A CA    1 
ATOM 3804 C C     . VAL A 1 539 ? 93.138  92.410  135.195 1.00 57.51  ? 539 VAL A C     1 
ATOM 3805 O O     . VAL A 1 539 ? 92.070  92.495  135.812 1.00 55.71  ? 539 VAL A O     1 
ATOM 3806 C CB    . VAL A 1 539 ? 93.791  90.814  133.339 1.00 54.53  ? 539 VAL A CB    1 
ATOM 3807 C CG1   . VAL A 1 539 ? 93.142  89.712  134.144 1.00 50.63  ? 539 VAL A CG1   1 
ATOM 3808 C CG2   . VAL A 1 539 ? 93.640  90.534  131.855 1.00 52.04  ? 539 VAL A CG2   1 
ATOM 3809 N N     . LEU A 1 540 ? 94.315  92.519  135.809 1.00 58.22  ? 540 LEU A N     1 
ATOM 3810 C CA    . LEU A 1 540 ? 94.409  92.555  137.265 1.00 60.03  ? 540 LEU A CA    1 
ATOM 3811 C C     . LEU A 1 540 ? 95.152  93.777  137.777 1.00 62.40  ? 540 LEU A C     1 
ATOM 3812 O O     . LEU A 1 540 ? 94.781  94.323  138.823 1.00 63.55  ? 540 LEU A O     1 
ATOM 3813 C CB    . LEU A 1 540 ? 95.073  91.275  137.811 1.00 60.39  ? 540 LEU A CB    1 
ATOM 3814 C CG    . LEU A 1 540 ? 96.534  90.833  137.641 1.00 57.83  ? 540 LEU A CG    1 
ATOM 3815 C CD1   . LEU A 1 540 ? 96.694  89.513  138.357 1.00 65.71  ? 540 LEU A CD1   1 
ATOM 3816 C CD2   . LEU A 1 540 ? 97.025  90.695  136.226 1.00 51.52  ? 540 LEU A CD2   1 
ATOM 3817 N N     . GLY A 1 541 ? 96.197  94.222  137.084 1.00 65.38  ? 541 GLY A N     1 
ATOM 3818 C CA    . GLY A 1 541 ? 96.729  95.541  137.360 1.00 59.40  ? 541 GLY A CA    1 
ATOM 3819 C C     . GLY A 1 541 ? 98.023  95.723  138.134 1.00 58.41  ? 541 GLY A C     1 
ATOM 3820 O O     . GLY A 1 541 ? 98.076  96.562  139.036 1.00 55.18  ? 541 GLY A O     1 
ATOM 3821 N N     . MET A 1 542 ? 99.072  94.974  137.814 1.00 55.61  ? 542 MET A N     1 
ATOM 3822 C CA    . MET A 1 542 ? 100.399 95.295  138.328 1.00 51.31  ? 542 MET A CA    1 
ATOM 3823 C C     . MET A 1 542 ? 101.207 95.995  137.241 1.00 56.45  ? 542 MET A C     1 
ATOM 3824 O O     . MET A 1 542 ? 101.147 95.606  136.071 1.00 60.69  ? 542 MET A O     1 
ATOM 3825 C CB    . MET A 1 542 ? 101.133 94.044  138.807 1.00 50.94  ? 542 MET A CB    1 
ATOM 3826 C CG    . MET A 1 542 ? 100.646 92.759  138.194 1.00 52.34  ? 542 MET A CG    1 
ATOM 3827 S SD    . MET A 1 542 ? 101.425 91.339  138.970 1.00 59.92  ? 542 MET A SD    1 
ATOM 3828 C CE    . MET A 1 542 ? 100.133 90.849  140.096 1.00 58.22  ? 542 MET A CE    1 
ATOM 3829 N N     . ALA A 1 543 ? 101.955 97.033  137.629 1.00 55.77  ? 543 ALA A N     1 
ATOM 3830 C CA    . ALA A 1 543 ? 102.759 97.802  136.682 1.00 52.15  ? 543 ALA A CA    1 
ATOM 3831 C C     . ALA A 1 543 ? 104.003 97.027  136.269 1.00 52.34  ? 543 ALA A C     1 
ATOM 3832 O O     . ALA A 1 543 ? 104.840 96.686  137.111 1.00 54.60  ? 543 ALA A O     1 
ATOM 3833 C CB    . ALA A 1 543 ? 103.147 99.157  137.276 1.00 44.76  ? 543 ALA A CB    1 
ATOM 3834 N N     . THR A 1 544 ? 104.133 96.760  134.971 1.00 40.23  ? 544 THR A N     1 
ATOM 3835 C CA    . THR A 1 544 ? 105.123 95.835  134.430 1.00 38.74  ? 544 THR A CA    1 
ATOM 3836 C C     . THR A 1 544 ? 106.272 96.604  133.786 1.00 42.36  ? 544 THR A C     1 
ATOM 3837 O O     . THR A 1 544 ? 106.092 97.208  132.725 1.00 40.49  ? 544 THR A O     1 
ATOM 3838 C CB    . THR A 1 544 ? 104.471 94.929  133.387 1.00 42.29  ? 544 THR A CB    1 
ATOM 3839 O OG1   . THR A 1 544 ? 103.616 95.722  132.557 1.00 45.59  ? 544 THR A OG1   1 
ATOM 3840 C CG2   . THR A 1 544 ? 103.632 93.858  134.050 1.00 39.63  ? 544 THR A CG2   1 
ATOM 3841 N N     . GLN A 1 545 ? 107.452 96.556  134.401 1.00 39.45  ? 545 GLN A N     1 
ATOM 3842 C CA    . GLN A 1 545 ? 108.668 97.089  133.795 1.00 40.39  ? 545 GLN A CA    1 
ATOM 3843 C C     . GLN A 1 545 ? 109.499 95.967  133.197 1.00 39.21  ? 545 GLN A C     1 
ATOM 3844 O O     . GLN A 1 545 ? 109.677 94.915  133.819 1.00 39.10  ? 545 GLN A O     1 
ATOM 3845 C CB    . GLN A 1 545 ? 109.517 97.861  134.799 1.00 44.77  ? 545 GLN A CB    1 
ATOM 3846 C CG    . GLN A 1 545 ? 110.052 99.184  134.268 1.00 38.10  ? 545 GLN A CG    1 
ATOM 3847 C CD    . GLN A 1 545 ? 111.131 99.027  133.215 1.00 38.95  ? 545 GLN A CD    1 
ATOM 3848 O OE1   . GLN A 1 545 ? 112.003 98.168  133.329 1.00 37.77  ? 545 GLN A OE1   1 
ATOM 3849 N NE2   . GLN A 1 545 ? 111.092 99.873  132.194 1.00 38.56  ? 545 GLN A NE2   1 
ATOM 3850 N N     . CYS A 1 546 ? 110.039 96.217  132.005 1.00 33.60  ? 546 CYS A N     1 
ATOM 3851 C CA    . CYS A 1 546 ? 110.611 95.163  131.191 1.00 32.00  ? 546 CYS A CA    1 
ATOM 3852 C C     . CYS A 1 546 ? 112.032 95.498  130.775 1.00 30.00  ? 546 CYS A C     1 
ATOM 3853 O O     . CYS A 1 546 ? 112.320 96.590  130.285 1.00 31.52  ? 546 CYS A O     1 
ATOM 3854 C CB    . CYS A 1 546 ? 109.758 94.908  129.971 1.00 27.15  ? 546 CYS A CB    1 
ATOM 3855 S SG    . CYS A 1 546 ? 108.158 94.257  130.431 1.00 45.48  ? 546 CYS A SG    1 
ATOM 3856 N N     . VAL A 1 547 ? 112.922 94.530  130.988 1.00 26.49  ? 547 VAL A N     1 
ATOM 3857 C CA    . VAL A 1 547 ? 114.329 94.625  130.637 1.00 20.35  ? 547 VAL A CA    1 
ATOM 3858 C C     . VAL A 1 547 ? 114.620 93.453  129.704 1.00 34.12  ? 547 VAL A C     1 
ATOM 3859 O O     . VAL A 1 547 ? 113.994 92.401  129.796 1.00 45.54  ? 547 VAL A O     1 
ATOM 3860 C CB    . VAL A 1 547 ? 115.243 94.570  131.887 1.00 19.02  ? 547 VAL A CB    1 
ATOM 3861 C CG1   . VAL A 1 547 ? 116.669 94.990  131.580 1.00 26.33  ? 547 VAL A CG1   1 
ATOM 3862 C CG2   . VAL A 1 547 ? 114.672 95.376  133.034 1.00 30.52  ? 547 VAL A CG2   1 
ATOM 3863 N N     . GLN A 1 548 ? 115.551 93.638  128.776 1.00 37.49  ? 548 GLN A N     1 
ATOM 3864 C CA    . GLN A 1 548 ? 116.089 92.514  128.025 1.00 27.95  ? 548 GLN A CA    1 
ATOM 3865 C C     . GLN A 1 548 ? 117.431 92.126  128.625 1.00 34.94  ? 548 GLN A C     1 
ATOM 3866 O O     . GLN A 1 548 ? 118.044 92.920  129.344 1.00 40.85  ? 548 GLN A O     1 
ATOM 3867 C CB    . GLN A 1 548 ? 116.253 92.844  126.550 1.00 30.28  ? 548 GLN A CB    1 
ATOM 3868 C CG    . GLN A 1 548 ? 115.070 93.557  125.946 1.00 32.90  ? 548 GLN A CG    1 
ATOM 3869 C CD    . GLN A 1 548 ? 115.227 93.751  124.459 1.00 35.31  ? 548 GLN A CD    1 
ATOM 3870 O OE1   . GLN A 1 548 ? 114.302 94.191  123.778 1.00 36.54  ? 548 GLN A OE1   1 
ATOM 3871 N NE2   . GLN A 1 548 ? 116.397 93.407  123.939 1.00 35.41  ? 548 GLN A NE2   1 
ATOM 3872 N N     . MET A 1 549 ? 117.900 90.912  128.314 1.00 25.74  ? 549 MET A N     1 
ATOM 3873 C CA    . MET A 1 549 ? 119.204 90.469  128.805 1.00 30.59  ? 549 MET A CA    1 
ATOM 3874 C C     . MET A 1 549 ? 120.356 91.211  128.150 1.00 27.30  ? 549 MET A C     1 
ATOM 3875 O O     . MET A 1 549 ? 121.470 91.181  128.679 1.00 25.63  ? 549 MET A O     1 
ATOM 3876 C CB    . MET A 1 549 ? 119.418 88.973  128.571 1.00 37.28  ? 549 MET A CB    1 
ATOM 3877 C CG    . MET A 1 549 ? 118.235 88.076  128.837 1.00 38.29  ? 549 MET A CG    1 
ATOM 3878 S SD    . MET A 1 549 ? 116.850 88.473  127.779 1.00 48.88  ? 549 MET A SD    1 
ATOM 3879 C CE    . MET A 1 549 ? 117.259 87.552  126.304 1.00 30.79  ? 549 MET A CE    1 
ATOM 3880 N N     . LYS A 1 550 ? 120.111 91.896  127.026 1.00 36.26  ? 550 LYS A N     1 
ATOM 3881 C CA    . LYS A 1 550 ? 121.171 92.615  126.325 1.00 36.39  ? 550 LYS A CA    1 
ATOM 3882 C C     . LYS A 1 550 ? 121.629 93.853  127.089 1.00 39.15  ? 550 LYS A C     1 
ATOM 3883 O O     . LYS A 1 550 ? 122.667 94.434  126.756 1.00 43.83  ? 550 LYS A O     1 
ATOM 3884 C CB    . LYS A 1 550 ? 120.700 92.995  124.920 1.00 33.69  ? 550 LYS A CB    1 
ATOM 3885 C CG    . LYS A 1 550 ? 119.704 94.142  124.862 1.00 34.49  ? 550 LYS A CG    1 
ATOM 3886 C CD    . LYS A 1 550 ? 119.556 94.642  123.433 1.00 41.66  ? 550 LYS A CD    1 
ATOM 3887 C CE    . LYS A 1 550 ? 118.661 95.863  123.345 1.00 39.66  ? 550 LYS A CE    1 
ATOM 3888 N NZ    . LYS A 1 550 ? 118.595 96.386  121.954 1.00 34.99  ? 550 LYS A NZ    1 
ATOM 3889 N N     . ASN A 1 551 ? 120.873 94.278  128.101 1.00 38.73  ? 551 ASN A N     1 
ATOM 3890 C CA    . ASN A 1 551 ? 121.338 95.297  129.029 1.00 36.05  ? 551 ASN A CA    1 
ATOM 3891 C C     . ASN A 1 551 ? 121.626 94.729  130.413 1.00 42.40  ? 551 ASN A C     1 
ATOM 3892 O O     . ASN A 1 551 ? 122.141 95.449  131.275 1.00 43.39  ? 551 ASN A O     1 
ATOM 3893 C CB    . ASN A 1 551 ? 120.309 96.424  129.125 1.00 34.54  ? 551 ASN A CB    1 
ATOM 3894 C CG    . ASN A 1 551 ? 119.789 96.847  127.771 1.00 30.07  ? 551 ASN A CG    1 
ATOM 3895 O OD1   . ASN A 1 551 ? 118.589 96.972  127.568 1.00 30.24  ? 551 ASN A OD1   1 
ATOM 3896 N ND2   . ASN A 1 551 ? 120.698 97.089  126.839 1.00 25.81  ? 551 ASN A ND2   1 
ATOM 3897 N N     . VAL A 1 552 ? 121.309 93.453  130.640 1.00 42.17  ? 552 VAL A N     1 
ATOM 3898 C CA    . VAL A 1 552 ? 121.619 92.808  131.915 1.00 39.28  ? 552 VAL A CA    1 
ATOM 3899 C C     . VAL A 1 552 ? 123.010 92.179  131.879 1.00 37.30  ? 552 VAL A C     1 
ATOM 3900 O O     . VAL A 1 552 ? 123.799 92.331  132.820 1.00 27.24  ? 552 VAL A O     1 
ATOM 3901 C CB    . VAL A 1 552 ? 120.538 91.767  132.263 1.00 37.75  ? 552 VAL A CB    1 
ATOM 3902 C CG1   . VAL A 1 552 ? 120.881 91.015  133.544 1.00 35.17  ? 552 VAL A CG1   1 
ATOM 3903 C CG2   . VAL A 1 552 ? 119.210 92.444  132.424 1.00 30.15  ? 552 VAL A CG2   1 
ATOM 3904 N N     . GLN A 1 553 ? 123.320 91.463  130.790 1.00 50.26  ? 553 GLN A N     1 
ATOM 3905 C CA    . GLN A 1 553 ? 124.596 90.769  130.634 1.00 52.27  ? 553 GLN A CA    1 
ATOM 3906 C C     . GLN A 1 553 ? 125.771 91.739  130.579 1.00 52.82  ? 553 GLN A C     1 
ATOM 3907 O O     . GLN A 1 553 ? 126.781 91.555  131.267 1.00 54.56  ? 553 GLN A O     1 
ATOM 3908 C CB    . GLN A 1 553 ? 124.565 89.905  129.367 1.00 52.34  ? 553 GLN A CB    1 
ATOM 3909 C CG    . GLN A 1 553 ? 123.579 88.747  129.396 1.00 44.52  ? 553 GLN A CG    1 
ATOM 3910 C CD    . GLN A 1 553 ? 123.633 87.958  130.684 1.00 49.62  ? 553 GLN A CD    1 
ATOM 3911 O OE1   . GLN A 1 553 ? 124.628 87.296  130.974 1.00 50.44  ? 553 GLN A OE1   1 
ATOM 3912 N NE2   . GLN A 1 553 ? 122.561 88.019  131.464 1.00 55.10  ? 553 GLN A NE2   1 
ATOM 3913 N N     . ARG A 1 554 ? 125.646 92.786  129.770 1.00 44.22  ? 554 ARG A N     1 
ATOM 3914 C CA    . ARG A 1 554 ? 126.609 93.877  129.752 1.00 48.08  ? 554 ARG A CA    1 
ATOM 3915 C C     . ARG A 1 554 ? 125.987 95.073  130.462 1.00 45.78  ? 554 ARG A C     1 
ATOM 3916 O O     . ARG A 1 554 ? 124.871 95.488  130.129 1.00 40.73  ? 554 ARG A O     1 
ATOM 3917 C CB    . ARG A 1 554 ? 127.021 94.241  128.324 1.00 50.44  ? 554 ARG A CB    1 
ATOM 3918 C CG    . ARG A 1 554 ? 125.907 94.161  127.297 1.00 46.67  ? 554 ARG A CG    1 
ATOM 3919 C CD    . ARG A 1 554 ? 126.043 95.269  126.261 1.00 51.04  ? 554 ARG A CD    1 
ATOM 3920 N NE    . ARG A 1 554 ? 125.588 96.554  126.782 1.00 48.37  ? 554 ARG A NE    1 
ATOM 3921 C CZ    . ARG A 1 554 ? 125.417 97.646  126.050 1.00 42.78  ? 554 ARG A CZ    1 
ATOM 3922 N NH1   . ARG A 1 554 ? 125.633 97.644  124.745 1.00 38.66  ? 554 ARG A NH1   1 
ATOM 3923 N NH2   . ARG A 1 554 ? 125.020 98.769  126.641 1.00 39.59  ? 554 ARG A NH2   1 
ATOM 3924 N N     . THR A 1 555 ? 126.692 95.606  131.452 1.00 51.47  ? 555 THR A N     1 
ATOM 3925 C CA    . THR A 1 555 ? 126.208 96.736  132.228 1.00 49.93  ? 555 THR A CA    1 
ATOM 3926 C C     . THR A 1 555 ? 127.300 97.784  132.393 1.00 47.76  ? 555 THR A C     1 
ATOM 3927 O O     . THR A 1 555 ? 128.491 97.462  132.455 1.00 51.18  ? 555 THR A O     1 
ATOM 3928 C CB    . THR A 1 555 ? 125.697 96.288  133.601 1.00 50.48  ? 555 THR A CB    1 
ATOM 3929 O OG1   . THR A 1 555 ? 125.433 97.440  134.412 1.00 40.97  ? 555 THR A OG1   1 
ATOM 3930 C CG2   . THR A 1 555 ? 126.709 95.386  134.300 1.00 50.64  ? 555 THR A CG2   1 
ATOM 3931 N N     . THR A 1 556 ? 126.877 99.042  132.422 1.00 48.74  ? 556 THR A N     1 
ATOM 3932 C CA    . THR A 1 556 ? 127.679 100.198 132.787 1.00 53.11  ? 556 THR A CA    1 
ATOM 3933 C C     . THR A 1 556 ? 126.833 101.009 133.760 1.00 48.37  ? 556 THR A C     1 
ATOM 3934 O O     . THR A 1 556 ? 125.609 100.826 133.791 1.00 43.00  ? 556 THR A O     1 
ATOM 3935 C CB    . THR A 1 556 ? 128.092 101.023 131.547 1.00 51.76  ? 556 THR A CB    1 
ATOM 3936 O OG1   . THR A 1 556 ? 127.029 101.061 130.593 1.00 55.60  ? 556 THR A OG1   1 
ATOM 3937 C CG2   . THR A 1 556 ? 129.331 100.422 130.896 1.00 48.52  ? 556 THR A CG2   1 
ATOM 3938 N N     . PRO A 1 557 ? 127.453 101.834 134.627 1.00 47.64  ? 557 PRO A N     1 
ATOM 3939 C CA    . PRO A 1 557 ? 126.663 102.580 135.632 1.00 45.91  ? 557 PRO A CA    1 
ATOM 3940 C C     . PRO A 1 557 ? 125.618 103.530 135.067 1.00 48.06  ? 557 PRO A C     1 
ATOM 3941 O O     . PRO A 1 557 ? 124.565 103.709 135.693 1.00 54.29  ? 557 PRO A O     1 
ATOM 3942 C CB    . PRO A 1 557 ? 127.740 103.342 136.414 1.00 47.25  ? 557 PRO A CB    1 
ATOM 3943 C CG    . PRO A 1 557 ? 128.925 102.486 136.323 1.00 46.57  ? 557 PRO A CG    1 
ATOM 3944 C CD    . PRO A 1 557 ? 128.893 101.878 134.957 1.00 48.29  ? 557 PRO A CD    1 
ATOM 3945 N N     . GLN A 1 558 ? 125.870 104.130 133.905 1.00 46.93  ? 558 GLN A N     1 
ATOM 3946 C CA    . GLN A 1 558 ? 124.837 104.876 133.204 1.00 42.86  ? 558 GLN A CA    1 
ATOM 3947 C C     . GLN A 1 558 ? 123.678 103.991 132.772 1.00 38.34  ? 558 GLN A C     1 
ATOM 3948 O O     . GLN A 1 558 ? 122.528 104.353 133.030 1.00 42.94  ? 558 GLN A O     1 
ATOM 3949 C CB    . GLN A 1 558 ? 125.439 105.578 131.984 1.00 46.89  ? 558 GLN A CB    1 
ATOM 3950 C CG    . GLN A 1 558 ? 124.786 106.898 131.604 1.00 48.39  ? 558 GLN A CG    1 
ATOM 3951 C CD    . GLN A 1 558 ? 123.678 106.728 130.588 1.00 49.02  ? 558 GLN A CD    1 
ATOM 3952 O OE1   . GLN A 1 558 ? 123.751 105.865 129.717 1.00 51.72  ? 558 GLN A OE1   1 
ATOM 3953 N NE2   . GLN A 1 558 ? 122.654 107.562 130.681 1.00 44.72  ? 558 GLN A NE2   1 
ATOM 3954 N N     . THR A 1 559 ? 123.971 102.817 132.196 1.00 36.83  ? 559 THR A N     1 
ATOM 3955 C CA    . THR A 1 559 ? 123.016 101.864 131.631 1.00 44.34  ? 559 THR A CA    1 
ATOM 3956 C C     . THR A 1 559 ? 122.025 101.319 132.658 1.00 56.00  ? 559 THR A C     1 
ATOM 3957 O O     . THR A 1 559 ? 120.882 101.001 132.305 1.00 58.75  ? 559 THR A O     1 
ATOM 3958 C CB    . THR A 1 559 ? 123.807 100.711 130.986 1.00 42.47  ? 559 THR A CB    1 
ATOM 3959 O OG1   . THR A 1 559 ? 124.758 101.261 130.067 1.00 50.00  ? 559 THR A OG1   1 
ATOM 3960 C CG2   . THR A 1 559 ? 122.930 99.729  130.214 1.00 43.27  ? 559 THR A CG2   1 
ATOM 3961 N N     . LEU A 1 560 ? 122.416 101.223 133.925 1.00 53.43  ? 560 LEU A N     1 
ATOM 3962 C CA    . LEU A 1 560 ? 121.481 100.790 134.954 1.00 35.95  ? 560 LEU A CA    1 
ATOM 3963 C C     . LEU A 1 560 ? 120.982 101.914 135.838 1.00 29.23  ? 560 LEU A C     1 
ATOM 3964 O O     . LEU A 1 560 ? 119.912 101.773 136.440 1.00 35.14  ? 560 LEU A O     1 
ATOM 3965 C CB    . LEU A 1 560 ? 122.108 99.716  135.835 1.00 32.71  ? 560 LEU A CB    1 
ATOM 3966 C CG    . LEU A 1 560 ? 121.629 98.308  135.524 1.00 34.24  ? 560 LEU A CG    1 
ATOM 3967 C CD1   . LEU A 1 560 ? 120.216 98.285  136.000 1.00 40.03  ? 560 LEU A CD1   1 
ATOM 3968 C CD2   . LEU A 1 560 ? 121.717 97.922  134.056 1.00 31.38  ? 560 LEU A CD2   1 
ATOM 3969 N N     . SER A 1 561 ? 121.730 103.019 135.932 1.00 40.14  ? 561 SER A N     1 
ATOM 3970 C CA    . SER A 1 561 ? 121.222 104.203 136.613 1.00 43.73  ? 561 SER A CA    1 
ATOM 3971 C C     . SER A 1 561 ? 120.000 104.750 135.898 1.00 37.74  ? 561 SER A C     1 
ATOM 3972 O O     . SER A 1 561 ? 119.026 105.161 136.542 1.00 37.50  ? 561 SER A O     1 
ATOM 3973 C CB    . SER A 1 561 ? 122.306 105.272 136.701 1.00 43.55  ? 561 SER A CB    1 
ATOM 3974 O OG    . SER A 1 561 ? 122.278 106.097 135.552 1.00 42.62  ? 561 SER A OG    1 
ATOM 3975 N N     . ASN A 1 562 ? 120.001 104.713 134.564 1.00 30.61  ? 562 ASN A N     1 
ATOM 3976 C CA    . ASN A 1 562 ? 118.798 105.182 133.893 1.00 38.70  ? 562 ASN A CA    1 
ATOM 3977 C C     . ASN A 1 562 ? 117.653 104.179 133.995 1.00 43.55  ? 562 ASN A C     1 
ATOM 3978 O O     . ASN A 1 562 ? 116.490 104.586 133.980 1.00 44.13  ? 562 ASN A O     1 
ATOM 3979 C CB    . ASN A 1 562 ? 119.075 105.593 132.458 1.00 36.72  ? 562 ASN A CB    1 
ATOM 3980 C CG    . ASN A 1 562 ? 119.857 104.603 131.703 1.00 35.47  ? 562 ASN A CG    1 
ATOM 3981 O OD1   . ASN A 1 562 ? 119.578 103.424 131.730 1.00 37.85  ? 562 ASN A OD1   1 
ATOM 3982 N ND2   . ASN A 1 562 ? 120.906 105.072 131.056 1.00 39.77  ? 562 ASN A ND2   1 
ATOM 3983 N N     . LEU A 1 563 ? 117.950 102.892 134.188 1.00 42.21  ? 563 LEU A N     1 
ATOM 3984 C CA    . LEU A 1 563 ? 116.878 101.935 134.453 1.00 39.82  ? 563 LEU A CA    1 
ATOM 3985 C C     . LEU A 1 563 ? 116.271 102.144 135.837 1.00 42.10  ? 563 LEU A C     1 
ATOM 3986 O O     . LEU A 1 563 ? 115.053 101.997 136.013 1.00 34.75  ? 563 LEU A O     1 
ATOM 3987 C CB    . LEU A 1 563 ? 117.395 100.507 134.309 1.00 35.90  ? 563 LEU A CB    1 
ATOM 3988 C CG    . LEU A 1 563 ? 116.348 99.393  134.341 1.00 42.01  ? 563 LEU A CG    1 
ATOM 3989 C CD1   . LEU A 1 563 ? 115.195 99.686  133.395 1.00 41.58  ? 563 LEU A CD1   1 
ATOM 3990 C CD2   . LEU A 1 563 ? 117.014 98.097  133.973 1.00 38.74  ? 563 LEU A CD2   1 
ATOM 3991 N N     . CYS A 1 564 ? 117.102 102.491 136.828 1.00 48.91  ? 564 CYS A N     1 
ATOM 3992 C CA    . CYS A 1 564 ? 116.574 102.766 138.162 1.00 38.98  ? 564 CYS A CA    1 
ATOM 3993 C C     . CYS A 1 564 ? 115.753 104.041 138.158 1.00 36.79  ? 564 CYS A C     1 
ATOM 3994 O O     . CYS A 1 564 ? 114.752 104.144 138.873 1.00 43.17  ? 564 CYS A O     1 
ATOM 3995 C CB    . CYS A 1 564 ? 117.691 102.866 139.205 1.00 43.29  ? 564 CYS A CB    1 
ATOM 3996 S SG    . CYS A 1 564 ? 118.318 104.518 139.586 1.00 35.44  ? 564 CYS A SG    1 
ATOM 3997 N N     . LEU A 1 565 ? 116.120 105.005 137.323 1.00 32.19  ? 565 LEU A N     1 
ATOM 3998 C CA    . LEU A 1 565 ? 115.240 106.159 137.274 1.00 32.28  ? 565 LEU A CA    1 
ATOM 3999 C C     . LEU A 1 565 ? 114.051 105.984 136.329 1.00 40.32  ? 565 LEU A C     1 
ATOM 4000 O O     . LEU A 1 565 ? 113.143 106.818 136.367 1.00 41.03  ? 565 LEU A O     1 
ATOM 4001 C CB    . LEU A 1 565 ? 116.018 107.425 136.929 1.00 43.56  ? 565 LEU A CB    1 
ATOM 4002 C CG    . LEU A 1 565 ? 116.924 107.629 135.738 1.00 37.51  ? 565 LEU A CG    1 
ATOM 4003 C CD1   . LEU A 1 565 ? 116.235 108.409 134.704 1.00 32.09  ? 565 LEU A CD1   1 
ATOM 4004 C CD2   . LEU A 1 565 ? 118.200 108.345 136.129 1.00 38.91  ? 565 LEU A CD2   1 
ATOM 4005 N N     . LYS A 1 566 ? 114.018 104.943 135.488 1.00 38.46  ? 566 LYS A N     1 
ATOM 4006 C CA    . LYS A 1 566 ? 112.757 104.594 134.824 1.00 30.97  ? 566 LYS A CA    1 
ATOM 4007 C C     . LYS A 1 566 ? 111.798 103.902 135.793 1.00 38.83  ? 566 LYS A C     1 
ATOM 4008 O O     . LYS A 1 566 ? 110.603 104.232 135.849 1.00 39.43  ? 566 LYS A O     1 
ATOM 4009 C CB    . LYS A 1 566 ? 113.001 103.684 133.618 1.00 26.55  ? 566 LYS A CB    1 
ATOM 4010 C CG    . LYS A 1 566 ? 113.700 104.311 132.418 1.00 38.10  ? 566 LYS A CG    1 
ATOM 4011 C CD    . LYS A 1 566 ? 112.844 105.175 131.524 1.00 42.81  ? 566 LYS A CD    1 
ATOM 4012 C CE    . LYS A 1 566 ? 113.753 106.090 130.703 1.00 37.43  ? 566 LYS A CE    1 
ATOM 4013 N NZ    . LYS A 1 566 ? 113.011 107.173 130.023 1.00 20.98  ? 566 LYS A NZ    1 
ATOM 4014 N N     . ILE A 1 567 ? 112.301 102.946 136.579 1.00 39.43  ? 567 ILE A N     1 
ATOM 4015 C CA    . ILE A 1 567 ? 111.445 102.283 137.558 1.00 27.16  ? 567 ILE A CA    1 
ATOM 4016 C C     . ILE A 1 567 ? 111.141 103.167 138.762 1.00 29.68  ? 567 ILE A C     1 
ATOM 4017 O O     . ILE A 1 567 ? 110.274 102.807 139.564 1.00 34.93  ? 567 ILE A O     1 
ATOM 4018 C CB    . ILE A 1 567 ? 112.030 100.951 138.058 1.00 34.25  ? 567 ILE A CB    1 
ATOM 4019 C CG1   . ILE A 1 567 ? 113.251 101.180 138.937 1.00 46.10  ? 567 ILE A CG1   1 
ATOM 4020 C CG2   . ILE A 1 567 ? 112.427 100.089 136.904 1.00 38.52  ? 567 ILE A CG2   1 
ATOM 4021 C CD1   . ILE A 1 567 ? 113.782 99.919  139.574 1.00 40.55  ? 567 ILE A CD1   1 
ATOM 4022 N N     . ASN A 1 568 ? 111.862 104.280 138.939 1.00 40.05  ? 568 ASN A N     1 
ATOM 4023 C CA    . ASN A 1 568 ? 111.448 105.289 139.906 1.00 33.85  ? 568 ASN A CA    1 
ATOM 4024 C C     . ASN A 1 568 ? 110.100 105.873 139.538 1.00 42.83  ? 568 ASN A C     1 
ATOM 4025 O O     . ASN A 1 568 ? 109.173 105.892 140.352 1.00 54.39  ? 568 ASN A O     1 
ATOM 4026 C CB    . ASN A 1 568 ? 112.466 106.422 139.962 1.00 37.64  ? 568 ASN A CB    1 
ATOM 4027 C CG    . ASN A 1 568 ? 112.039 107.533 140.904 1.00 43.56  ? 568 ASN A CG    1 
ATOM 4028 O OD1   . ASN A 1 568 ? 111.946 107.327 142.109 1.00 44.05  ? 568 ASN A OD1   1 
ATOM 4029 N ND2   . ASN A 1 568 ? 111.762 108.712 140.357 1.00 42.99  ? 568 ASN A ND2   1 
ATOM 4030 N N     . VAL A 1 569 ? 109.965 106.337 138.298 1.00 38.37  ? 569 VAL A N     1 
ATOM 4031 C CA    . VAL A 1 569 ? 108.761 107.061 137.918 1.00 42.78  ? 569 VAL A CA    1 
ATOM 4032 C C     . VAL A 1 569 ? 107.670 106.087 137.500 1.00 47.51  ? 569 VAL A C     1 
ATOM 4033 O O     . VAL A 1 569 ? 106.507 106.497 137.376 1.00 48.36  ? 569 VAL A O     1 
ATOM 4034 C CB    . VAL A 1 569 ? 109.209 108.084 136.850 1.00 40.83  ? 569 VAL A CB    1 
ATOM 4035 C CG1   . VAL A 1 569 ? 109.939 107.404 135.737 1.00 28.55  ? 569 VAL A CG1   1 
ATOM 4036 C CG2   . VAL A 1 569 ? 108.127 109.066 136.384 1.00 44.82  ? 569 VAL A CG2   1 
ATOM 4037 N N     . LYS A 1 570 ? 108.027 104.798 137.332 1.00 40.07  ? 570 LYS A N     1 
ATOM 4038 C CA    . LYS A 1 570 ? 107.073 103.738 136.988 1.00 38.44  ? 570 LYS A CA    1 
ATOM 4039 C C     . LYS A 1 570 ? 105.916 103.644 137.977 1.00 37.81  ? 570 LYS A C     1 
ATOM 4040 O O     . LYS A 1 570 ? 104.749 103.636 137.577 1.00 33.25  ? 570 LYS A O     1 
ATOM 4041 C CB    . LYS A 1 570 ? 107.790 102.396 136.922 1.00 39.08  ? 570 LYS A CB    1 
ATOM 4042 C CG    . LYS A 1 570 ? 107.869 101.773 135.550 1.00 39.00  ? 570 LYS A CG    1 
ATOM 4043 C CD    . LYS A 1 570 ? 106.522 101.456 134.946 1.00 43.24  ? 570 LYS A CD    1 
ATOM 4044 C CE    . LYS A 1 570 ? 106.706 100.672 133.664 1.00 31.05  ? 570 LYS A CE    1 
ATOM 4045 N NZ    . LYS A 1 570 ? 107.366 101.467 132.623 1.00 26.30  ? 570 LYS A NZ    1 
ATOM 4046 N N     . LEU A 1 571 ? 106.220 103.585 139.274 1.00 41.33  ? 571 LEU A N     1 
ATOM 4047 C CA    . LEU A 1 571 ? 105.162 103.654 140.276 1.00 43.80  ? 571 LEU A CA    1 
ATOM 4048 C C     . LEU A 1 571 ? 104.581 105.058 140.332 1.00 43.75  ? 571 LEU A C     1 
ATOM 4049 O O     . LEU A 1 571 ? 103.391 105.272 140.078 1.00 49.68  ? 571 LEU A O     1 
ATOM 4050 C CB    . LEU A 1 571 ? 105.691 103.254 141.655 1.00 41.52  ? 571 LEU A CB    1 
ATOM 4051 C CG    . LEU A 1 571 ? 106.524 101.998 141.881 1.00 32.57  ? 571 LEU A CG    1 
ATOM 4052 C CD1   . LEU A 1 571 ? 107.982 102.321 141.842 1.00 28.88  ? 571 LEU A CD1   1 
ATOM 4053 C CD2   . LEU A 1 571 ? 106.167 101.389 143.211 1.00 41.17  ? 571 LEU A CD2   1 
ATOM 4054 N N     . GLY A 1 572 ? 105.421 106.027 140.664 1.00 42.75  ? 572 GLY A N     1 
ATOM 4055 C CA    . GLY A 1 572 ? 105.111 107.429 140.512 1.00 48.01  ? 572 GLY A CA    1 
ATOM 4056 C C     . GLY A 1 572 ? 105.886 108.251 141.513 1.00 51.09  ? 572 GLY A C     1 
ATOM 4057 O O     . GLY A 1 572 ? 105.851 107.983 142.716 1.00 44.44  ? 572 GLY A O     1 
ATOM 4058 N N     . GLY A 1 573 ? 106.527 109.294 141.024 1.00 47.54  ? 573 GLY A N     1 
ATOM 4059 C CA    . GLY A 1 573 ? 107.385 110.139 141.830 1.00 49.37  ? 573 GLY A CA    1 
ATOM 4060 C C     . GLY A 1 573 ? 108.073 111.164 140.956 1.00 53.42  ? 573 GLY A C     1 
ATOM 4061 O O     . GLY A 1 573 ? 107.986 111.131 139.733 1.00 54.03  ? 573 GLY A O     1 
ATOM 4062 N N     . VAL A 1 574 ? 108.770 112.087 141.611 1.00 53.25  ? 574 VAL A N     1 
ATOM 4063 C CA    . VAL A 1 574 ? 109.392 113.229 140.952 1.00 46.44  ? 574 VAL A CA    1 
ATOM 4064 C C     . VAL A 1 574 ? 110.897 113.023 140.961 1.00 49.49  ? 574 VAL A C     1 
ATOM 4065 O O     . VAL A 1 574 ? 111.483 112.735 142.010 1.00 59.44  ? 574 VAL A O     1 
ATOM 4066 C CB    . VAL A 1 574 ? 109.006 114.547 141.644 1.00 48.63  ? 574 VAL A CB    1 
ATOM 4067 C CG1   . VAL A 1 574 ? 109.729 115.715 141.015 1.00 47.54  ? 574 VAL A CG1   1 
ATOM 4068 C CG2   . VAL A 1 574 ? 107.506 114.753 141.582 1.00 51.96  ? 574 VAL A CG2   1 
ATOM 4069 N N     . ASN A 1 575 ? 111.519 113.159 139.790 1.00 45.36  ? 575 ASN A N     1 
ATOM 4070 C CA    . ASN A 1 575 ? 112.946 112.919 139.604 1.00 41.43  ? 575 ASN A CA    1 
ATOM 4071 C C     . ASN A 1 575 ? 113.735 114.188 139.325 1.00 44.61  ? 575 ASN A C     1 
ATOM 4072 O O     . ASN A 1 575 ? 114.951 114.219 139.532 1.00 50.37  ? 575 ASN A O     1 
ATOM 4073 C CB    . ASN A 1 575 ? 113.147 111.964 138.443 1.00 33.76  ? 575 ASN A CB    1 
ATOM 4074 C CG    . ASN A 1 575 ? 113.857 110.739 138.833 1.00 34.69  ? 575 ASN A CG    1 
ATOM 4075 O OD1   . ASN A 1 575 ? 114.025 110.439 140.005 1.00 30.21  ? 575 ASN A OD1   1 
ATOM 4076 N ND2   . ASN A 1 575 ? 114.241 109.983 137.848 1.00 40.42  ? 575 ASN A ND2   1 
ATOM 4077 N N     . ASN A 1 576 ? 113.079 115.221 138.828 1.00 46.68  ? 576 ASN A N     1 
ATOM 4078 C CA    . ASN A 1 576 ? 113.760 116.427 138.399 1.00 27.15  ? 576 ASN A CA    1 
ATOM 4079 C C     . ASN A 1 576 ? 112.779 117.567 138.566 1.00 28.57  ? 576 ASN A C     1 
ATOM 4080 O O     . ASN A 1 576 ? 111.562 117.383 138.482 1.00 39.03  ? 576 ASN A O     1 
ATOM 4081 C CB    . ASN A 1 576 ? 114.239 116.306 136.954 1.00 27.58  ? 576 ASN A CB    1 
ATOM 4082 C CG    . ASN A 1 576 ? 113.109 116.403 135.958 1.00 36.27  ? 576 ASN A CG    1 
ATOM 4083 O OD1   . ASN A 1 576 ? 112.845 117.465 135.405 1.00 38.18  ? 576 ASN A OD1   1 
ATOM 4084 N ND2   . ASN A 1 576 ? 112.418 115.293 135.738 1.00 49.32  ? 576 ASN A ND2   1 
ATOM 4085 N N     . ILE A 1 577 ? 113.318 118.746 138.830 1.00 38.09  ? 577 ILE A N     1 
ATOM 4086 C CA    . ILE A 1 577 ? 112.501 119.945 138.832 1.00 45.92  ? 577 ILE A CA    1 
ATOM 4087 C C     . ILE A 1 577 ? 113.371 121.064 138.285 1.00 48.48  ? 577 ILE A C     1 
ATOM 4088 O O     . ILE A 1 577 ? 114.548 121.180 138.634 1.00 53.29  ? 577 ILE A O     1 
ATOM 4089 C CB    . ILE A 1 577 ? 111.934 120.231 140.247 1.00 43.97  ? 577 ILE A CB    1 
ATOM 4090 C CG1   . ILE A 1 577 ? 111.306 121.622 140.346 1.00 47.81  ? 577 ILE A CG1   1 
ATOM 4091 C CG2   . ILE A 1 577 ? 112.998 120.034 141.311 1.00 48.45  ? 577 ILE A CG2   1 
ATOM 4092 C CD1   . ILE A 1 577 ? 110.059 121.785 139.494 1.00 39.24  ? 577 ILE A CD1   1 
ATOM 4093 N N     . LEU A 1 578 ? 112.812 121.839 137.367 1.00 39.44  ? 578 LEU A N     1 
ATOM 4094 C CA    . LEU A 1 578 ? 113.544 122.967 136.828 1.00 39.08  ? 578 LEU A CA    1 
ATOM 4095 C C     . LEU A 1 578 ? 113.645 124.065 137.887 1.00 48.02  ? 578 LEU A C     1 
ATOM 4096 O O     . LEU A 1 578 ? 112.902 124.077 138.872 1.00 46.57  ? 578 LEU A O     1 
ATOM 4097 C CB    . LEU A 1 578 ? 112.860 123.462 135.558 1.00 42.47  ? 578 LEU A CB    1 
ATOM 4098 C CG    . LEU A 1 578 ? 112.334 122.304 134.697 1.00 35.83  ? 578 LEU A CG    1 
ATOM 4099 C CD1   . LEU A 1 578 ? 111.333 122.787 133.671 1.00 35.45  ? 578 LEU A CD1   1 
ATOM 4100 C CD2   . LEU A 1 578 ? 113.455 121.547 134.018 1.00 33.25  ? 578 LEU A CD2   1 
ATOM 4101 N N     . LEU A 1 579 ? 114.615 124.957 137.709 1.00 65.52  ? 579 LEU A N     1 
ATOM 4102 C CA    . LEU A 1 579 ? 114.837 126.008 138.695 1.00 67.26  ? 579 LEU A CA    1 
ATOM 4103 C C     . LEU A 1 579 ? 113.682 127.002 138.662 1.00 68.49  ? 579 LEU A C     1 
ATOM 4104 O O     . LEU A 1 579 ? 113.252 127.399 137.579 1.00 67.73  ? 579 LEU A O     1 
ATOM 4105 C CB    . LEU A 1 579 ? 116.146 126.747 138.436 1.00 67.42  ? 579 LEU A CB    1 
ATOM 4106 C CG    . LEU A 1 579 ? 117.375 126.376 139.262 1.00 64.16  ? 579 LEU A CG    1 
ATOM 4107 C CD1   . LEU A 1 579 ? 117.262 126.955 140.657 1.00 64.00  ? 579 LEU A CD1   1 
ATOM 4108 C CD2   . LEU A 1 579 ? 117.573 124.894 139.323 1.00 52.91  ? 579 LEU A CD2   1 
ATOM 4109 N N     . PRO A 1 580 ? 113.135 127.377 139.827 1.00 76.97  ? 580 PRO A N     1 
ATOM 4110 C CA    . PRO A 1 580 ? 112.048 128.377 139.859 1.00 78.53  ? 580 PRO A CA    1 
ATOM 4111 C C     . PRO A 1 580 ? 112.435 129.737 139.303 1.00 75.74  ? 580 PRO A C     1 
ATOM 4112 O O     . PRO A 1 580 ? 111.579 130.442 138.756 1.00 72.96  ? 580 PRO A O     1 
ATOM 4113 C CB    . PRO A 1 580 ? 111.699 128.459 141.351 1.00 81.24  ? 580 PRO A CB    1 
ATOM 4114 C CG    . PRO A 1 580 ? 112.124 127.141 141.911 1.00 81.03  ? 580 PRO A CG    1 
ATOM 4115 C CD    . PRO A 1 580 ? 113.350 126.748 141.141 1.00 78.19  ? 580 PRO A CD    1 
ATOM 4116 N N     . GLN A 1 581 ? 113.704 130.121 139.426 1.00 88.08  ? 581 GLN A N     1 
ATOM 4117 C CA    . GLN A 1 581 ? 114.205 131.283 138.704 1.00 92.72  ? 581 GLN A CA    1 
ATOM 4118 C C     . GLN A 1 581 ? 114.347 130.973 137.217 1.00 91.88  ? 581 GLN A C     1 
ATOM 4119 O O     . GLN A 1 581 ? 114.141 131.844 136.364 1.00 92.61  ? 581 GLN A O     1 
ATOM 4120 C CB    . GLN A 1 581 ? 115.543 131.734 139.298 1.00 90.45  ? 581 GLN A CB    1 
ATOM 4121 C CG    . GLN A 1 581 ? 116.426 130.605 139.836 1.00 92.21  ? 581 GLN A CG    1 
ATOM 4122 C CD    . GLN A 1 581 ? 116.253 130.370 141.329 1.00 91.44  ? 581 GLN A CD    1 
ATOM 4123 O OE1   . GLN A 1 581 ? 115.145 130.452 141.859 1.00 86.80  ? 581 GLN A OE1   1 
ATOM 4124 N NE2   . GLN A 1 581 ? 117.353 130.088 142.013 1.00 91.84  ? 581 GLN A NE2   1 
ATOM 4125 N N     . GLY A 1 582 ? 114.704 129.729 136.890 1.00 67.49  ? 582 GLY A N     1 
ATOM 4126 C CA    . GLY A 1 582 ? 114.895 129.366 135.493 1.00 68.93  ? 582 GLY A CA    1 
ATOM 4127 C C     . GLY A 1 582 ? 113.613 128.941 134.804 1.00 62.14  ? 582 GLY A C     1 
ATOM 4128 O O     . GLY A 1 582 ? 113.566 128.808 133.580 1.00 62.50  ? 582 GLY A O     1 
ATOM 4129 N N     . ARG A 1 583 ? 112.559 128.705 135.581 1.00 58.17  ? 583 ARG A N     1 
ATOM 4130 C CA    . ARG A 1 583 ? 111.277 128.299 135.016 1.00 64.76  ? 583 ARG A CA    1 
ATOM 4131 C C     . ARG A 1 583 ? 110.601 129.457 134.288 1.00 63.84  ? 583 ARG A C     1 
ATOM 4132 O O     . ARG A 1 583 ? 110.667 130.604 134.745 1.00 62.54  ? 583 ARG A O     1 
ATOM 4133 C CB    . ARG A 1 583 ? 110.352 127.745 136.106 1.00 70.95  ? 583 ARG A CB    1 
ATOM 4134 C CG    . ARG A 1 583 ? 110.465 126.228 136.304 1.00 66.91  ? 583 ARG A CG    1 
ATOM 4135 C CD    . ARG A 1 583 ? 110.326 125.785 137.763 1.00 60.63  ? 583 ARG A CD    1 
ATOM 4136 N NE    . ARG A 1 583 ? 108.949 125.612 138.209 1.00 58.29  ? 583 ARG A NE    1 
ATOM 4137 C CZ    . ARG A 1 583 ? 108.258 126.500 138.910 1.00 63.24  ? 583 ARG A CZ    1 
ATOM 4138 N NH1   . ARG A 1 583 ? 108.784 127.654 139.276 1.00 61.89  ? 583 ARG A NH1   1 
ATOM 4139 N NH2   . ARG A 1 583 ? 106.999 126.226 139.239 1.00 66.52  ? 583 ARG A NH2   1 
ATOM 4140 N N     . PRO A 1 584 ? 109.971 129.194 133.147 1.00 70.32  ? 584 PRO A N     1 
ATOM 4141 C CA    . PRO A 1 584 ? 109.154 130.216 132.477 1.00 71.59  ? 584 PRO A CA    1 
ATOM 4142 C C     . PRO A 1 584 ? 107.918 130.551 133.295 1.00 68.62  ? 584 PRO A C     1 
ATOM 4143 O O     . PRO A 1 584 ? 107.523 129.773 134.175 1.00 63.42  ? 584 PRO A O     1 
ATOM 4144 C CB    . PRO A 1 584 ? 108.775 129.551 131.140 1.00 67.24  ? 584 PRO A CB    1 
ATOM 4145 C CG    . PRO A 1 584 ? 109.287 128.168 131.185 1.00 67.45  ? 584 PRO A CG    1 
ATOM 4146 C CD    . PRO A 1 584 ? 110.305 128.075 132.254 1.00 70.10  ? 584 PRO A CD    1 
ATOM 4147 N N     . PRO A 1 585 ? 107.264 131.693 133.027 1.00 71.79  ? 585 PRO A N     1 
ATOM 4148 C CA    . PRO A 1 585 ? 106.078 132.070 133.825 1.00 70.08  ? 585 PRO A CA    1 
ATOM 4149 C C     . PRO A 1 585 ? 104.842 131.198 133.622 1.00 69.19  ? 585 PRO A C     1 
ATOM 4150 O O     . PRO A 1 585 ? 103.822 131.456 134.274 1.00 72.19  ? 585 PRO A O     1 
ATOM 4151 C CB    . PRO A 1 585 ? 105.804 133.513 133.382 1.00 70.91  ? 585 PRO A CB    1 
ATOM 4152 C CG    . PRO A 1 585 ? 107.108 134.014 132.905 1.00 68.11  ? 585 PRO A CG    1 
ATOM 4153 C CD    . PRO A 1 585 ? 107.775 132.843 132.257 1.00 72.16  ? 585 PRO A CD    1 
ATOM 4154 N N     . VAL A 1 586 ? 104.883 130.200 132.734 1.00 59.19  ? 586 VAL A N     1 
ATOM 4155 C CA    . VAL A 1 586 ? 103.851 129.166 132.717 1.00 63.16  ? 586 VAL A CA    1 
ATOM 4156 C C     . VAL A 1 586 ? 103.910 128.343 134.004 1.00 64.77  ? 586 VAL A C     1 
ATOM 4157 O O     . VAL A 1 586 ? 102.875 127.954 134.562 1.00 63.61  ? 586 VAL A O     1 
ATOM 4158 C CB    . VAL A 1 586 ? 103.996 128.304 131.442 1.00 63.11  ? 586 VAL A CB    1 
ATOM 4159 C CG1   . VAL A 1 586 ? 105.428 127.828 131.246 1.00 67.08  ? 586 VAL A CG1   1 
ATOM 4160 C CG2   . VAL A 1 586 ? 103.027 127.129 131.429 1.00 55.48  ? 586 VAL A CG2   1 
ATOM 4161 N N     . PHE A 1 587 ? 105.118 128.143 134.541 1.00 65.48  ? 587 PHE A N     1 
ATOM 4162 C CA    . PHE A 1 587 ? 105.322 127.269 135.689 1.00 62.51  ? 587 PHE A CA    1 
ATOM 4163 C C     . PHE A 1 587 ? 104.865 127.888 137.003 1.00 65.20  ? 587 PHE A C     1 
ATOM 4164 O O     . PHE A 1 587 ? 104.770 127.177 138.009 1.00 62.83  ? 587 PHE A O     1 
ATOM 4165 C CB    . PHE A 1 587 ? 106.792 126.904 135.786 1.00 58.56  ? 587 PHE A CB    1 
ATOM 4166 C CG    . PHE A 1 587 ? 107.142 125.660 135.064 1.00 61.60  ? 587 PHE A CG    1 
ATOM 4167 C CD1   . PHE A 1 587 ? 107.439 125.692 133.713 1.00 64.44  ? 587 PHE A CD1   1 
ATOM 4168 C CD2   . PHE A 1 587 ? 107.176 124.455 135.731 1.00 61.73  ? 587 PHE A CD2   1 
ATOM 4169 C CE1   . PHE A 1 587 ? 107.766 124.533 133.040 1.00 64.56  ? 587 PHE A CE1   1 
ATOM 4170 C CE2   . PHE A 1 587 ? 107.494 123.303 135.069 1.00 61.61  ? 587 PHE A CE2   1 
ATOM 4171 C CZ    . PHE A 1 587 ? 107.790 123.336 133.721 1.00 58.45  ? 587 PHE A CZ    1 
ATOM 4172 N N     . GLN A 1 588 ? 104.594 129.194 137.026 1.00 68.76  ? 588 GLN A N     1 
ATOM 4173 C CA    . GLN A 1 588 ? 104.029 129.829 138.208 1.00 64.07  ? 588 GLN A CA    1 
ATOM 4174 C C     . GLN A 1 588 ? 102.555 129.501 138.392 1.00 64.55  ? 588 GLN A C     1 
ATOM 4175 O O     . GLN A 1 588 ? 102.019 129.717 139.484 1.00 72.37  ? 588 GLN A O     1 
ATOM 4176 C CB    . GLN A 1 588 ? 104.226 131.341 138.123 1.00 64.63  ? 588 GLN A CB    1 
ATOM 4177 C CG    . GLN A 1 588 ? 105.678 131.755 137.972 1.00 64.23  ? 588 GLN A CG    1 
ATOM 4178 C CD    . GLN A 1 588 ? 105.825 133.125 137.349 1.00 67.94  ? 588 GLN A CD    1 
ATOM 4179 O OE1   . GLN A 1 588 ? 104.930 133.600 136.654 1.00 66.93  ? 588 GLN A OE1   1 
ATOM 4180 N NE2   . GLN A 1 588 ? 106.960 133.767 137.594 1.00 72.28  ? 588 GLN A NE2   1 
ATOM 4181 N N     . GLN A 1 589 ? 101.897 128.997 137.360 1.00 59.94  ? 589 GLN A N     1 
ATOM 4182 C CA    . GLN A 1 589 ? 100.548 128.462 137.412 1.00 64.26  ? 589 GLN A CA    1 
ATOM 4183 C C     . GLN A 1 589 ? 100.642 126.954 137.240 1.00 69.44  ? 589 GLN A C     1 
ATOM 4184 O O     . GLN A 1 589 ? 101.660 126.448 136.754 1.00 67.88  ? 589 GLN A O     1 
ATOM 4185 C CB    . GLN A 1 589 ? 99.677  129.088 136.312 1.00 63.34  ? 589 GLN A CB    1 
ATOM 4186 C CG    . GLN A 1 589 ? 99.456  130.580 136.497 1.00 62.77  ? 589 GLN A CG    1 
ATOM 4187 C CD    . GLN A 1 589 ? 98.505  131.165 135.471 1.00 67.69  ? 589 GLN A CD    1 
ATOM 4188 O OE1   . GLN A 1 589 ? 97.596  130.488 134.990 1.00 70.57  ? 589 GLN A OE1   1 
ATOM 4189 N NE2   . GLN A 1 589 ? 98.712  132.431 135.129 1.00 67.19  ? 589 GLN A NE2   1 
ATOM 4190 N N     . PRO A 1 590 ? 99.638  126.198 137.701 1.00 71.09  ? 590 PRO A N     1 
ATOM 4191 C CA    . PRO A 1 590 ? 99.633  124.749 137.446 1.00 64.15  ? 590 PRO A CA    1 
ATOM 4192 C C     . PRO A 1 590 ? 99.517  124.432 135.960 1.00 61.55  ? 590 PRO A C     1 
ATOM 4193 O O     . PRO A 1 590 ? 98.845  125.138 135.206 1.00 65.20  ? 590 PRO A O     1 
ATOM 4194 C CB    . PRO A 1 590 ? 98.410  124.259 138.224 1.00 64.23  ? 590 PRO A CB    1 
ATOM 4195 C CG    . PRO A 1 590 ? 98.231  125.255 139.304 1.00 69.44  ? 590 PRO A CG    1 
ATOM 4196 C CD    . PRO A 1 590 ? 98.639  126.571 138.721 1.00 64.65  ? 590 PRO A CD    1 
ATOM 4197 N N     . VAL A 1 591 ? 100.184 123.359 135.543 1.00 55.24  ? 591 VAL A N     1 
ATOM 4198 C CA    . VAL A 1 591 ? 100.404 123.087 134.128 1.00 56.72  ? 591 VAL A CA    1 
ATOM 4199 C C     . VAL A 1 591 ? 100.344 121.581 133.873 1.00 59.79  ? 591 VAL A C     1 
ATOM 4200 O O     . VAL A 1 591 ? 100.901 120.781 134.633 1.00 65.39  ? 591 VAL A O     1 
ATOM 4201 C CB    . VAL A 1 591 ? 101.740 123.724 133.673 1.00 57.49  ? 591 VAL A CB    1 
ATOM 4202 C CG1   . VAL A 1 591 ? 102.887 123.354 134.613 1.00 58.09  ? 591 VAL A CG1   1 
ATOM 4203 C CG2   . VAL A 1 591 ? 102.072 123.381 132.234 1.00 55.64  ? 591 VAL A CG2   1 
ATOM 4204 N N     . ILE A 1 592 ? 99.629  121.197 132.815 1.00 47.80  ? 592 ILE A N     1 
ATOM 4205 C CA    . ILE A 1 592 ? 99.502  119.809 132.376 1.00 45.71  ? 592 ILE A CA    1 
ATOM 4206 C C     . ILE A 1 592 ? 100.286 119.647 131.075 1.00 47.15  ? 592 ILE A C     1 
ATOM 4207 O O     . ILE A 1 592 ? 100.054 120.374 130.100 1.00 52.21  ? 592 ILE A O     1 
ATOM 4208 C CB    . ILE A 1 592 ? 98.014  119.400 132.239 1.00 54.62  ? 592 ILE A CB    1 
ATOM 4209 C CG1   . ILE A 1 592 ? 97.784  117.967 131.743 1.00 49.44  ? 592 ILE A CG1   1 
ATOM 4210 C CG2   . ILE A 1 592 ? 97.150  120.429 131.543 1.00 58.14  ? 592 ILE A CG2   1 
ATOM 4211 C CD1   . ILE A 1 592 ? 98.544  116.935 132.443 1.00 45.80  ? 592 ILE A CD1   1 
ATOM 4212 N N     . PHE A 1 593 ? 101.242 118.720 131.075 1.00 44.88  ? 593 PHE A N     1 
ATOM 4213 C CA    . PHE A 1 593 ? 102.037 118.411 129.891 1.00 43.90  ? 593 PHE A CA    1 
ATOM 4214 C C     . PHE A 1 593 ? 101.444 117.174 129.230 1.00 46.86  ? 593 PHE A C     1 
ATOM 4215 O O     . PHE A 1 593 ? 101.479 116.079 129.798 1.00 56.39  ? 593 PHE A O     1 
ATOM 4216 C CB    . PHE A 1 593 ? 103.503 118.171 130.238 1.00 35.18  ? 593 PHE A CB    1 
ATOM 4217 C CG    . PHE A 1 593 ? 104.096 119.191 131.159 1.00 42.20  ? 593 PHE A CG    1 
ATOM 4218 C CD1   . PHE A 1 593 ? 104.478 120.435 130.681 1.00 44.57  ? 593 PHE A CD1   1 
ATOM 4219 C CD2   . PHE A 1 593 ? 104.296 118.899 132.502 1.00 47.21  ? 593 PHE A CD2   1 
ATOM 4220 C CE1   . PHE A 1 593 ? 105.041 121.376 131.525 1.00 52.59  ? 593 PHE A CE1   1 
ATOM 4221 C CE2   . PHE A 1 593 ? 104.855 119.838 133.355 1.00 47.36  ? 593 PHE A CE2   1 
ATOM 4222 C CZ    . PHE A 1 593 ? 105.227 121.077 132.863 1.00 47.32  ? 593 PHE A CZ    1 
ATOM 4223 N N     . LEU A 1 594 ? 100.930 117.342 128.023 1.00 28.49  ? 594 LEU A N     1 
ATOM 4224 C CA    . LEU A 1 594 ? 100.222 116.287 127.323 1.00 14.21  ? 594 LEU A CA    1 
ATOM 4225 C C     . LEU A 1 594 ? 100.998 115.865 126.083 1.00 14.96  ? 594 LEU A C     1 
ATOM 4226 O O     . LEU A 1 594 ? 101.749 116.646 125.501 1.00 40.12  ? 594 LEU A O     1 
ATOM 4227 C CB    . LEU A 1 594 ? 98.834  116.769 126.926 1.00 23.06  ? 594 LEU A CB    1 
ATOM 4228 C CG    . LEU A 1 594 ? 97.630  116.366 127.754 1.00 33.31  ? 594 LEU A CG    1 
ATOM 4229 C CD1   . LEU A 1 594 ? 96.385  116.925 127.131 1.00 37.65  ? 594 LEU A CD1   1 
ATOM 4230 C CD2   . LEU A 1 594 ? 97.560  114.898 127.764 1.00 36.54  ? 594 LEU A CD2   1 
ATOM 4231 N N     . GLY A 1 595 ? 100.844 114.610 125.698 1.00 6.36   ? 595 GLY A N     1 
ATOM 4232 C CA    . GLY A 1 595 ? 101.508 114.146 124.499 1.00 12.28  ? 595 GLY A CA    1 
ATOM 4233 C C     . GLY A 1 595 ? 100.728 113.045 123.828 1.00 28.00  ? 595 GLY A C     1 
ATOM 4234 O O     . GLY A 1 595 ? 100.318 112.102 124.500 1.00 49.21  ? 595 GLY A O     1 
ATOM 4235 N N     . ALA A 1 596 ? 100.500 113.146 122.526 1.00 15.87  ? 596 ALA A N     1 
ATOM 4236 C CA    . ALA A 1 596 ? 99.700  112.176 121.796 1.00 25.88  ? 596 ALA A CA    1 
ATOM 4237 C C     . ALA A 1 596 ? 100.577 111.355 120.863 1.00 32.74  ? 596 ALA A C     1 
ATOM 4238 O O     . ALA A 1 596 ? 101.727 111.701 120.596 1.00 35.17  ? 596 ALA A O     1 
ATOM 4239 C CB    . ALA A 1 596 ? 98.600  112.874 121.000 1.00 27.82  ? 596 ALA A CB    1 
ATOM 4240 N N     . ASP A 1 597 ? 100.024 110.234 120.397 1.00 33.20  ? 597 ASP A N     1 
ATOM 4241 C CA    . ASP A 1 597 ? 100.692 109.394 119.410 1.00 30.79  ? 597 ASP A CA    1 
ATOM 4242 C C     . ASP A 1 597 ? 99.704  108.487 118.697 1.00 44.06  ? 597 ASP A C     1 
ATOM 4243 O O     . ASP A 1 597 ? 98.987  107.713 119.335 1.00 40.09  ? 597 ASP A O     1 
ATOM 4244 C CB    . ASP A 1 597 ? 101.780 108.533 120.047 1.00 20.97  ? 597 ASP A CB    1 
ATOM 4245 C CG    . ASP A 1 597 ? 102.838 108.110 119.053 1.00 33.57  ? 597 ASP A CG    1 
ATOM 4246 O OD1   . ASP A 1 597 ? 102.572 107.197 118.245 1.00 38.25  ? 597 ASP A OD1   1 
ATOM 4247 O OD2   . ASP A 1 597 ? 103.940 108.696 119.068 1.00 37.32  ? 597 ASP A OD2   1 
ATOM 4248 N N     . VAL A 1 598 ? 99.670  108.576 117.375 1.00 48.81  ? 598 VAL A N     1 
ATOM 4249 C CA    . VAL A 1 598 ? 98.978  107.616 116.546 1.00 40.90  ? 598 VAL A CA    1 
ATOM 4250 C C     . VAL A 1 598 ? 100.015 106.637 116.020 1.00 39.33  ? 598 VAL A C     1 
ATOM 4251 O O     . VAL A 1 598 ? 101.134 107.006 115.653 1.00 39.71  ? 598 VAL A O     1 
ATOM 4252 C CB    . VAL A 1 598 ? 98.206  108.293 115.392 1.00 41.00  ? 598 VAL A CB    1 
ATOM 4253 C CG1   . VAL A 1 598 ? 96.893  108.831 115.894 1.00 43.56  ? 598 VAL A CG1   1 
ATOM 4254 C CG2   . VAL A 1 598 ? 99.028  109.417 114.787 1.00 32.54  ? 598 VAL A CG2   1 
ATOM 4255 N N     . THR A 1 599 ? 99.656  105.351 115.996 1.00 38.45  ? 599 THR A N     1 
ATOM 4256 C CA    . THR A 1 599 ? 100.610 104.322 115.520 1.00 49.90  ? 599 THR A CA    1 
ATOM 4257 C C     . THR A 1 599 ? 99.850  103.235 114.789 1.00 48.72  ? 599 THR A C     1 
ATOM 4258 O O     . THR A 1 599 ? 100.076 103.109 113.565 1.00 43.61  ? 599 THR A O     1 
ATOM 4259 C CB    . THR A 1 599 ? 101.416 103.775 116.699 1.00 46.70  ? 599 THR A CB    1 
ATOM 4260 O OG1   . THR A 1 599 ? 102.406 104.761 116.976 1.00 37.78  ? 599 THR A OG1   1 
ATOM 4261 C CG2   . THR A 1 599 ? 102.094 102.454 116.388 1.00 53.59  ? 599 THR A CG2   1 
ATOM 4262 N N     . LYS A 1 608 ? 94.985  93.065  112.756 1.00 59.76  ? 608 LYS A N     1 
ATOM 4263 C CA    . LYS A 1 608 ? 95.925  93.935  113.453 1.00 61.35  ? 608 LYS A CA    1 
ATOM 4264 C C     . LYS A 1 608 ? 95.381  95.358  113.548 1.00 64.09  ? 608 LYS A C     1 
ATOM 4265 O O     . LYS A 1 608 ? 95.695  96.187  112.703 1.00 68.65  ? 608 LYS A O     1 
ATOM 4266 C CB    . LYS A 1 608 ? 97.280  93.938  112.741 1.00 58.86  ? 608 LYS A CB    1 
ATOM 4267 C CG    . LYS A 1 608 ? 98.186  92.773  113.109 1.00 60.36  ? 608 LYS A CG    1 
ATOM 4268 C CD    . LYS A 1 608 ? 99.653  93.156  113.002 1.00 60.66  ? 608 LYS A CD    1 
ATOM 4269 C CE    . LYS A 1 608 ? 100.501 92.381  113.998 1.00 63.73  ? 608 LYS A CE    1 
ATOM 4270 N NZ    . LYS A 1 608 ? 101.921 92.826  113.995 1.00 60.22  ? 608 LYS A NZ    1 
ATOM 4271 N N     . PRO A 1 609 ? 94.562  95.637  114.563 1.00 56.79  ? 609 PRO A N     1 
ATOM 4272 C CA    . PRO A 1 609 ? 93.993  96.983  114.698 1.00 55.97  ? 609 PRO A CA    1 
ATOM 4273 C C     . PRO A 1 609 ? 95.018  97.999  115.184 1.00 58.09  ? 609 PRO A C     1 
ATOM 4274 O O     . PRO A 1 609 ? 96.048  97.652  115.767 1.00 57.47  ? 609 PRO A O     1 
ATOM 4275 C CB    . PRO A 1 609 ? 92.867  96.791  115.717 1.00 58.94  ? 609 PRO A CB    1 
ATOM 4276 C CG    . PRO A 1 609 ? 93.270  95.605  116.503 1.00 59.58  ? 609 PRO A CG    1 
ATOM 4277 C CD    . PRO A 1 609 ? 94.037  94.710  115.581 1.00 56.66  ? 609 PRO A CD    1 
ATOM 4278 N N     . SER A 1 610 ? 94.715  99.274  114.929 1.00 54.46  ? 610 SER A N     1 
ATOM 4279 C CA    . SER A 1 610 ? 95.667  100.360 115.132 1.00 53.14  ? 610 SER A CA    1 
ATOM 4280 C C     . SER A 1 610 ? 95.495  101.006 116.508 1.00 53.09  ? 610 SER A C     1 
ATOM 4281 O O     . SER A 1 610 ? 94.796  100.499 117.386 1.00 52.85  ? 610 SER A O     1 
ATOM 4282 C CB    . SER A 1 610 ? 95.549  101.387 114.015 1.00 60.37  ? 610 SER A CB    1 
ATOM 4283 O OG    . SER A 1 610 ? 96.377  101.034 112.923 1.00 63.25  ? 610 SER A OG    1 
ATOM 4284 N N     . ILE A 1 611 ? 96.129  102.165 116.691 1.00 54.55  ? 611 ILE A N     1 
ATOM 4285 C CA    . ILE A 1 611 ? 96.599  102.616 117.993 1.00 57.36  ? 611 ILE A CA    1 
ATOM 4286 C C     . ILE A 1 611 ? 96.117  104.034 118.268 1.00 56.49  ? 611 ILE A C     1 
ATOM 4287 O O     . ILE A 1 611 ? 96.219  104.929 117.428 1.00 58.83  ? 611 ILE A O     1 
ATOM 4288 C CB    . ILE A 1 611 ? 98.146  102.542 118.066 1.00 54.90  ? 611 ILE A CB    1 
ATOM 4289 C CG1   . ILE A 1 611 ? 98.615  101.096 118.163 1.00 44.80  ? 611 ILE A CG1   1 
ATOM 4290 C CG2   . ILE A 1 611 ? 98.712  103.317 119.243 1.00 53.94  ? 611 ILE A CG2   1 
ATOM 4291 C CD1   . ILE A 1 611 ? 99.028  100.492 116.841 1.00 49.27  ? 611 ILE A CD1   1 
ATOM 4292 N N     . ALA A 1 612 ? 95.573  104.224 119.467 1.00 47.43  ? 612 ALA A N     1 
ATOM 4293 C CA    . ALA A 1 612 ? 95.312  105.544 120.011 1.00 51.80  ? 612 ALA A CA    1 
ATOM 4294 C C     . ALA A 1 612 ? 95.895  105.599 121.418 1.00 57.00  ? 612 ALA A C     1 
ATOM 4295 O O     . ALA A 1 612 ? 95.523  104.786 122.267 1.00 54.34  ? 612 ALA A O     1 
ATOM 4296 C CB    . ALA A 1 612 ? 93.807  105.824 120.013 1.00 56.26  ? 612 ALA A CB    1 
ATOM 4297 N N     . ALA A 1 613 ? 96.811  106.539 121.667 1.00 44.57  ? 613 ALA A N     1 
ATOM 4298 C CA    . ALA A 1 613 ? 97.544  106.562 122.932 1.00 39.35  ? 613 ALA A CA    1 
ATOM 4299 C C     . ALA A 1 613 ? 98.032  107.966 123.260 1.00 38.11  ? 613 ALA A C     1 
ATOM 4300 O O     . ALA A 1 613 ? 98.618  108.630 122.403 1.00 49.10  ? 613 ALA A O     1 
ATOM 4301 C CB    . ALA A 1 613 ? 98.732  105.608 122.879 1.00 38.54  ? 613 ALA A CB    1 
ATOM 4302 N N     . VAL A 1 614 ? 97.783  108.417 124.494 1.00 23.45  ? 614 VAL A N     1 
ATOM 4303 C CA    . VAL A 1 614 ? 98.044  109.790 124.933 1.00 28.01  ? 614 VAL A CA    1 
ATOM 4304 C C     . VAL A 1 614 ? 98.560  109.754 126.374 1.00 34.74  ? 614 VAL A C     1 
ATOM 4305 O O     . VAL A 1 614 ? 97.977  109.070 127.220 1.00 53.29  ? 614 VAL A O     1 
ATOM 4306 C CB    . VAL A 1 614 ? 96.780  110.673 124.823 1.00 36.71  ? 614 VAL A CB    1 
ATOM 4307 C CG1   . VAL A 1 614 ? 96.915  111.965 125.572 1.00 33.85  ? 614 VAL A CG1   1 
ATOM 4308 C CG2   . VAL A 1 614 ? 96.464  111.016 123.383 1.00 34.53  ? 614 VAL A CG2   1 
ATOM 4309 N N     . VAL A 1 615 ? 99.653  110.478 126.657 1.00 3.50   ? 615 VAL A N     1 
ATOM 4310 C CA    . VAL A 1 615 ? 100.197 110.603 128.011 1.00 9.55   ? 615 VAL A CA    1 
ATOM 4311 C C     . VAL A 1 615 ? 100.022 112.023 128.544 1.00 25.59  ? 615 VAL A C     1 
ATOM 4312 O O     . VAL A 1 615 ? 100.306 112.997 127.840 1.00 43.32  ? 615 VAL A O     1 
ATOM 4313 C CB    . VAL A 1 615 ? 101.684 110.201 128.039 1.00 10.37  ? 615 VAL A CB    1 
ATOM 4314 C CG1   . VAL A 1 615 ? 102.259 110.262 129.433 1.00 21.33  ? 615 VAL A CG1   1 
ATOM 4315 C CG2   . VAL A 1 615 ? 101.827 108.834 127.557 1.00 31.40  ? 615 VAL A CG2   1 
ATOM 4316 N N     . GLY A 1 616 ? 99.565  112.153 129.790 1.00 26.69  ? 616 GLY A N     1 
ATOM 4317 C CA    . GLY A 1 616 ? 99.569  113.435 130.472 1.00 23.87  ? 616 GLY A CA    1 
ATOM 4318 C C     . GLY A 1 616 ? 100.320 113.359 131.786 1.00 27.17  ? 616 GLY A C     1 
ATOM 4319 O O     . GLY A 1 616 ? 100.476 112.285 132.373 1.00 42.16  ? 616 GLY A O     1 
ATOM 4320 N N     . SER A 1 617 ? 100.780 114.524 132.243 1.00 20.67  ? 617 SER A N     1 
ATOM 4321 C CA    . SER A 1 617 ? 101.529 114.670 133.483 1.00 35.27  ? 617 SER A CA    1 
ATOM 4322 C C     . SER A 1 617 ? 100.602 114.678 134.699 1.00 39.88  ? 617 SER A C     1 
ATOM 4323 O O     . SER A 1 617 ? 99.383  114.515 134.591 1.00 42.56  ? 617 SER A O     1 
ATOM 4324 C CB    . SER A 1 617 ? 102.391 115.929 133.438 1.00 36.96  ? 617 SER A CB    1 
ATOM 4325 O OG    . SER A 1 617 ? 101.622 117.098 133.643 1.00 29.70  ? 617 SER A OG    1 
ATOM 4326 N N     . MET A 1 618 ? 101.195 114.853 135.885 1.00 37.94  ? 618 MET A N     1 
ATOM 4327 C CA    . MET A 1 618 ? 100.451 114.736 137.137 1.00 35.53  ? 618 MET A CA    1 
ATOM 4328 C C     . MET A 1 618 ? 100.607 115.955 138.039 1.00 37.27  ? 618 MET A C     1 
ATOM 4329 O O     . MET A 1 618 ? 99.821  116.137 138.972 1.00 36.08  ? 618 MET A O     1 
ATOM 4330 C CB    . MET A 1 618 ? 100.899 113.501 137.917 1.00 33.99  ? 618 MET A CB    1 
ATOM 4331 C CG    . MET A 1 618 ? 100.739 112.198 137.182 1.00 27.94  ? 618 MET A CG    1 
ATOM 4332 S SD    . MET A 1 618 ? 99.047  111.754 136.833 1.00 41.29  ? 618 MET A SD    1 
ATOM 4333 C CE    . MET A 1 618 ? 98.855  110.539 138.117 1.00 35.44  ? 618 MET A CE    1 
ATOM 4334 N N     . ASP A 1 619 ? 101.617 116.784 137.792 1.00 42.92  ? 619 ASP A N     1 
ATOM 4335 C CA    . ASP A 1 619 ? 101.985 117.799 138.769 1.00 48.65  ? 619 ASP A CA    1 
ATOM 4336 C C     . ASP A 1 619 ? 102.716 118.947 138.089 1.00 50.07  ? 619 ASP A C     1 
ATOM 4337 O O     . ASP A 1 619 ? 103.027 118.894 136.897 1.00 49.77  ? 619 ASP A O     1 
ATOM 4338 C CB    . ASP A 1 619 ? 102.856 117.193 139.868 1.00 51.01  ? 619 ASP A CB    1 
ATOM 4339 C CG    . ASP A 1 619 ? 103.863 116.210 139.320 1.00 51.30  ? 619 ASP A CG    1 
ATOM 4340 O OD1   . ASP A 1 619 ? 103.829 115.951 138.101 1.00 54.30  ? 619 ASP A OD1   1 
ATOM 4341 O OD2   . ASP A 1 619 ? 104.691 115.699 140.098 1.00 51.66  ? 619 ASP A OD2   1 
ATOM 4342 N N     . ALA A 1 620 ? 102.985 119.993 138.876 1.00 44.58  ? 620 ALA A N     1 
ATOM 4343 C CA    . ALA A 1 620 ? 103.800 121.098 138.386 1.00 41.21  ? 620 ALA A CA    1 
ATOM 4344 C C     . ALA A 1 620 ? 105.265 120.701 138.272 1.00 44.14  ? 620 ALA A C     1 
ATOM 4345 O O     . ALA A 1 620 ? 105.980 121.204 137.399 1.00 46.00  ? 620 ALA A O     1 
ATOM 4346 C CB    . ALA A 1 620 ? 103.643 122.311 139.301 1.00 45.19  ? 620 ALA A CB    1 
ATOM 4347 N N     . HIS A 1 621 ? 105.729 119.812 139.142 1.00 44.87  ? 621 HIS A N     1 
ATOM 4348 C CA    . HIS A 1 621 ? 107.063 119.241 139.036 1.00 45.26  ? 621 HIS A CA    1 
ATOM 4349 C C     . HIS A 1 621 ? 107.073 118.279 137.855 1.00 44.74  ? 621 HIS A C     1 
ATOM 4350 O O     . HIS A 1 621 ? 106.456 117.210 137.930 1.00 51.96  ? 621 HIS A O     1 
ATOM 4351 C CB    . HIS A 1 621 ? 107.441 118.495 140.315 1.00 49.77  ? 621 HIS A CB    1 
ATOM 4352 C CG    . HIS A 1 621 ? 107.689 119.374 141.499 1.00 53.09  ? 621 HIS A CG    1 
ATOM 4353 N ND1   . HIS A 1 621 ? 107.412 120.725 141.507 1.00 56.59  ? 621 HIS A ND1   1 
ATOM 4354 C CD2   . HIS A 1 621 ? 108.177 119.084 142.729 1.00 48.59  ? 621 HIS A CD2   1 
ATOM 4355 C CE1   . HIS A 1 621 ? 107.727 121.231 142.686 1.00 52.37  ? 621 HIS A CE1   1 
ATOM 4356 N NE2   . HIS A 1 621 ? 108.193 120.256 143.446 1.00 55.46  ? 621 HIS A NE2   1 
ATOM 4357 N N     . PRO A 1 622 ? 107.773 118.591 136.768 1.00 31.93  ? 622 PRO A N     1 
ATOM 4358 C CA    . PRO A 1 622 ? 107.568 117.838 135.523 1.00 31.94  ? 622 PRO A CA    1 
ATOM 4359 C C     . PRO A 1 622 ? 108.264 116.488 135.476 1.00 31.43  ? 622 PRO A C     1 
ATOM 4360 O O     . PRO A 1 622 ? 109.200 116.311 134.693 1.00 34.06  ? 622 PRO A O     1 
ATOM 4361 C CB    . PRO A 1 622 ? 108.144 118.772 134.451 1.00 30.96  ? 622 PRO A CB    1 
ATOM 4362 C CG    . PRO A 1 622 ? 108.654 119.973 135.180 1.00 42.20  ? 622 PRO A CG    1 
ATOM 4363 C CD    . PRO A 1 622 ? 108.816 119.607 136.606 1.00 41.28  ? 622 PRO A CD    1 
ATOM 4364 N N     . ASN A 1 623 ? 107.847 115.537 136.309 1.00 42.02  ? 623 ASN A N     1 
ATOM 4365 C CA    . ASN A 1 623 ? 108.303 114.167 136.123 1.00 36.15  ? 623 ASN A CA    1 
ATOM 4366 C C     . ASN A 1 623 ? 107.159 113.164 136.162 1.00 33.04  ? 623 ASN A C     1 
ATOM 4367 O O     . ASN A 1 623 ? 107.172 112.169 135.432 1.00 54.20  ? 623 ASN A O     1 
ATOM 4368 C CB    . ASN A 1 623 ? 109.327 113.773 137.177 1.00 35.14  ? 623 ASN A CB    1 
ATOM 4369 C CG    . ASN A 1 623 ? 109.921 112.419 136.901 1.00 28.73  ? 623 ASN A CG    1 
ATOM 4370 O OD1   . ASN A 1 623 ? 110.017 111.583 137.786 1.00 29.16  ? 623 ASN A OD1   1 
ATOM 4371 N ND2   . ASN A 1 623 ? 110.321 112.193 135.659 1.00 34.46  ? 623 ASN A ND2   1 
ATOM 4372 N N     . ARG A 1 624 ? 106.180 113.405 137.025 1.00 15.51  ? 624 ARG A N     1 
ATOM 4373 C CA    . ARG A 1 624 ? 105.098 112.460 137.257 1.00 28.37  ? 624 ARG A CA    1 
ATOM 4374 C C     . ARG A 1 624 ? 104.087 112.546 136.125 1.00 31.88  ? 624 ARG A C     1 
ATOM 4375 O O     . ARG A 1 624 ? 103.494 113.603 135.897 1.00 32.06  ? 624 ARG A O     1 
ATOM 4376 C CB    . ARG A 1 624 ? 104.430 112.749 138.599 1.00 37.59  ? 624 ARG A CB    1 
ATOM 4377 C CG    . ARG A 1 624 ? 104.754 111.751 139.670 1.00 39.78  ? 624 ARG A CG    1 
ATOM 4378 C CD    . ARG A 1 624 ? 104.268 112.181 141.048 1.00 36.85  ? 624 ARG A CD    1 
ATOM 4379 N NE    . ARG A 1 624 ? 102.870 111.863 141.303 1.00 42.27  ? 624 ARG A NE    1 
ATOM 4380 C CZ    . ARG A 1 624 ? 102.215 112.230 142.396 1.00 40.33  ? 624 ARG A CZ    1 
ATOM 4381 N NH1   . ARG A 1 624 ? 102.811 112.910 143.362 1.00 34.47  ? 624 ARG A NH1   1 
ATOM 4382 N NH2   . ARG A 1 624 ? 100.933 111.904 142.524 1.00 40.11  ? 624 ARG A NH2   1 
ATOM 4383 N N     . TYR A 1 625 ? 103.915 111.439 135.404 1.00 36.79  ? 625 TYR A N     1 
ATOM 4384 C CA    . TYR A 1 625 ? 102.956 111.330 134.312 1.00 32.07  ? 625 TYR A CA    1 
ATOM 4385 C C     . TYR A 1 625 ? 102.057 110.129 134.587 1.00 30.97  ? 625 TYR A C     1 
ATOM 4386 O O     . TYR A 1 625 ? 102.168 109.483 135.632 1.00 44.95  ? 625 TYR A O     1 
ATOM 4387 C CB    . TYR A 1 625 ? 103.656 111.203 132.948 1.00 24.23  ? 625 TYR A CB    1 
ATOM 4388 C CG    . TYR A 1 625 ? 104.230 112.493 132.386 1.00 27.56  ? 625 TYR A CG    1 
ATOM 4389 C CD1   . TYR A 1 625 ? 105.291 113.134 133.012 1.00 34.92  ? 625 TYR A CD1   1 
ATOM 4390 C CD2   . TYR A 1 625 ? 103.731 113.052 131.221 1.00 24.70  ? 625 TYR A CD2   1 
ATOM 4391 C CE1   . TYR A 1 625 ? 105.824 114.300 132.512 1.00 29.89  ? 625 TYR A CE1   1 
ATOM 4392 C CE2   . TYR A 1 625 ? 104.253 114.228 130.718 1.00 29.15  ? 625 TYR A CE2   1 
ATOM 4393 C CZ    . TYR A 1 625 ? 105.305 114.841 131.366 1.00 28.32  ? 625 TYR A CZ    1 
ATOM 4394 O OH    . TYR A 1 625 ? 105.852 116.003 130.880 1.00 28.60  ? 625 TYR A OH    1 
ATOM 4395 N N     . CYS A 1 626 ? 101.128 109.867 133.668 1.00 15.70  ? 626 CYS A N     1 
ATOM 4396 C CA    . CYS A 1 626 ? 100.371 108.622 133.610 1.00 26.12  ? 626 CYS A CA    1 
ATOM 4397 C C     . CYS A 1 626 ? 99.790  108.526 132.211 1.00 35.69  ? 626 CYS A C     1 
ATOM 4398 O O     . CYS A 1 626 ? 99.741  109.529 131.500 1.00 36.51  ? 626 CYS A O     1 
ATOM 4399 C CB    . CYS A 1 626 ? 99.263  108.536 134.672 1.00 38.40  ? 626 CYS A CB    1 
ATOM 4400 S SG    . CYS A 1 626 ? 97.719  109.352 134.293 1.00 42.31  ? 626 CYS A SG    1 
ATOM 4401 N N     . ALA A 1 627 ? 99.361  107.329 131.815 1.00 43.60  ? 627 ALA A N     1 
ATOM 4402 C CA    . ALA A 1 627 ? 99.083  107.051 130.414 1.00 31.06  ? 627 ALA A CA    1 
ATOM 4403 C C     . ALA A 1 627 ? 97.738  106.381 130.203 1.00 24.85  ? 627 ALA A C     1 
ATOM 4404 O O     . ALA A 1 627 ? 97.206  105.695 131.078 1.00 39.82  ? 627 ALA A O     1 
ATOM 4405 C CB    . ALA A 1 627 ? 100.155 106.156 129.811 1.00 26.23  ? 627 ALA A CB    1 
ATOM 4406 N N     . THR A 1 628 ? 97.205  106.588 129.000 1.00 18.07  ? 628 THR A N     1 
ATOM 4407 C CA    . THR A 1 628 ? 95.974  105.964 128.537 1.00 43.22  ? 628 THR A CA    1 
ATOM 4408 C C     . THR A 1 628 ? 96.280  105.161 127.281 1.00 53.58  ? 628 THR A C     1 
ATOM 4409 O O     . THR A 1 628 ? 97.178  105.524 126.516 1.00 53.21  ? 628 THR A O     1 
ATOM 4410 C CB    . THR A 1 628 ? 94.891  107.004 128.224 1.00 41.85  ? 628 THR A CB    1 
ATOM 4411 O OG1   . THR A 1 628 ? 95.186  107.632 126.974 1.00 42.03  ? 628 THR A OG1   1 
ATOM 4412 C CG2   . THR A 1 628 ? 94.830  108.059 129.295 1.00 35.39  ? 628 THR A CG2   1 
ATOM 4413 N N     . VAL A 1 629 ? 95.546  104.067 127.078 1.00 38.90  ? 629 VAL A N     1 
ATOM 4414 C CA    . VAL A 1 629 ? 95.621  103.264 125.862 1.00 27.63  ? 629 VAL A CA    1 
ATOM 4415 C C     . VAL A 1 629 ? 94.210  102.958 125.378 1.00 36.20  ? 629 VAL A C     1 
ATOM 4416 O O     . VAL A 1 629 ? 93.330  102.623 126.178 1.00 38.99  ? 629 VAL A O     1 
ATOM 4417 C CB    . VAL A 1 629 ? 96.420  101.964 126.071 1.00 25.92  ? 629 VAL A CB    1 
ATOM 4418 C CG1   . VAL A 1 629 ? 97.876  102.242 126.068 1.00 23.54  ? 629 VAL A CG1   1 
ATOM 4419 C CG2   . VAL A 1 629 ? 96.065  101.326 127.402 1.00 28.48  ? 629 VAL A CG2   1 
ATOM 4420 N N     . ARG A 1 630 ? 93.993  103.106 124.073 1.00 49.56  ? 630 ARG A N     1 
ATOM 4421 C CA    . ARG A 1 630 ? 92.809  102.589 123.402 1.00 55.36  ? 630 ARG A CA    1 
ATOM 4422 C C     . ARG A 1 630 ? 93.264  101.974 122.089 1.00 56.45  ? 630 ARG A C     1 
ATOM 4423 O O     . ARG A 1 630 ? 94.394  102.185 121.644 1.00 61.56  ? 630 ARG A O     1 
ATOM 4424 C CB    . ARG A 1 630 ? 91.747  103.668 123.139 1.00 53.82  ? 630 ARG A CB    1 
ATOM 4425 C CG    . ARG A 1 630 ? 91.060  104.239 124.375 1.00 53.35  ? 630 ARG A CG    1 
ATOM 4426 C CD    . ARG A 1 630 ? 90.259  103.195 125.135 1.00 54.16  ? 630 ARG A CD    1 
ATOM 4427 N NE    . ARG A 1 630 ? 89.703  103.734 126.371 1.00 56.58  ? 630 ARG A NE    1 
ATOM 4428 C CZ    . ARG A 1 630 ? 90.368  103.855 127.514 1.00 57.97  ? 630 ARG A CZ    1 
ATOM 4429 N NH1   . ARG A 1 630 ? 91.637  103.497 127.621 1.00 57.65  ? 630 ARG A NH1   1 
ATOM 4430 N NH2   . ARG A 1 630 ? 89.743  104.351 128.578 1.00 53.92  ? 630 ARG A NH2   1 
ATOM 4431 N N     . VAL A 1 631 ? 92.381  101.193 121.475 1.00 56.72  ? 631 VAL A N     1 
ATOM 4432 C CA    . VAL A 1 631 ? 92.657  100.518 120.211 1.00 58.30  ? 631 VAL A CA    1 
ATOM 4433 C C     . VAL A 1 631 ? 91.637  101.001 119.187 1.00 63.64  ? 631 VAL A C     1 
ATOM 4434 O O     . VAL A 1 631 ? 90.439  101.067 119.484 1.00 64.74  ? 631 VAL A O     1 
ATOM 4435 C CB    . VAL A 1 631 ? 92.615  98.982  120.364 1.00 61.69  ? 631 VAL A CB    1 
ATOM 4436 C CG1   . VAL A 1 631 ? 93.102  98.301  119.117 1.00 58.97  ? 631 VAL A CG1   1 
ATOM 4437 C CG2   . VAL A 1 631 ? 93.472  98.521  121.537 1.00 60.42  ? 631 VAL A CG2   1 
ATOM 4438 N N     . GLN A 1 632 ? 92.112  101.356 117.993 1.00 60.72  ? 632 GLN A N     1 
ATOM 4439 C CA    . GLN A 1 632 ? 91.267  101.862 116.918 1.00 60.21  ? 632 GLN A CA    1 
ATOM 4440 C C     . GLN A 1 632 ? 91.449  101.007 115.667 1.00 56.21  ? 632 GLN A C     1 
ATOM 4441 O O     . GLN A 1 632 ? 92.314  100.129 115.610 1.00 55.75  ? 632 GLN A O     1 
ATOM 4442 C CB    . GLN A 1 632 ? 91.572  103.340 116.622 1.00 60.85  ? 632 GLN A CB    1 
ATOM 4443 C CG    . GLN A 1 632 ? 92.761  103.572 115.694 1.00 60.43  ? 632 GLN A CG    1 
ATOM 4444 C CD    . GLN A 1 632 ? 93.058  105.037 115.473 1.00 58.77  ? 632 GLN A CD    1 
ATOM 4445 O OE1   . GLN A 1 632 ? 92.318  105.906 115.931 1.00 58.28  ? 632 GLN A OE1   1 
ATOM 4446 N NE2   . GLN A 1 632 ? 94.136  105.320 114.750 1.00 53.00  ? 632 GLN A NE2   1 
ATOM 4447 N N     . GLN A 1 633 ? 90.603  101.263 114.663 1.00 63.83  ? 633 GLN A N     1 
ATOM 4448 C CA    . GLN A 1 633 ? 90.660  100.521 113.408 1.00 69.63  ? 633 GLN A CA    1 
ATOM 4449 C C     . GLN A 1 633 ? 91.929  100.861 112.632 1.00 62.55  ? 633 GLN A C     1 
ATOM 4450 O O     . GLN A 1 633 ? 92.540  101.913 112.836 1.00 60.92  ? 633 GLN A O     1 
ATOM 4451 C CB    . GLN A 1 633 ? 89.413  100.811 112.561 1.00 69.96  ? 633 GLN A CB    1 
ATOM 4452 C CG    . GLN A 1 633 ? 89.518  102.008 111.617 1.00 66.12  ? 633 GLN A CG    1 
ATOM 4453 C CD    . GLN A 1 633 ? 88.211  102.762 111.471 1.00 67.36  ? 633 GLN A CD    1 
ATOM 4454 O OE1   . GLN A 1 633 ? 87.713  103.356 112.427 1.00 69.99  ? 633 GLN A OE1   1 
ATOM 4455 N NE2   . GLN A 1 633 ? 87.651  102.747 110.268 1.00 65.56  ? 633 GLN A NE2   1 
ATOM 4456 N N     . HIS A 1 634 ? 92.329  99.954  111.746 1.00 57.38  ? 634 HIS A N     1 
ATOM 4457 C CA    . HIS A 1 634 ? 93.645  100.039 111.136 1.00 56.24  ? 634 HIS A CA    1 
ATOM 4458 C C     . HIS A 1 634 ? 93.689  101.103 110.042 1.00 59.77  ? 634 HIS A C     1 
ATOM 4459 O O     . HIS A 1 634 ? 92.660  101.564 109.537 1.00 62.05  ? 634 HIS A O     1 
ATOM 4460 C CB    . HIS A 1 634 ? 94.064  98.689  110.561 1.00 61.89  ? 634 HIS A CB    1 
ATOM 4461 C CG    . HIS A 1 634 ? 95.543  98.456  110.596 1.00 61.94  ? 634 HIS A CG    1 
ATOM 4462 N ND1   . HIS A 1 634 ? 96.358  98.993  111.570 1.00 55.37  ? 634 HIS A ND1   1 
ATOM 4463 C CD2   . HIS A 1 634 ? 96.353  97.741  109.781 1.00 61.62  ? 634 HIS A CD2   1 
ATOM 4464 C CE1   . HIS A 1 634 ? 97.606  98.619  111.352 1.00 54.87  ? 634 HIS A CE1   1 
ATOM 4465 N NE2   . HIS A 1 634 ? 97.631  97.859  110.273 1.00 57.47  ? 634 HIS A NE2   1 
ATOM 4466 N N     . ARG A 1 635 ? 94.929  101.480 109.699 1.00 62.70  ? 635 ARG A N     1 
ATOM 4467 C CA    . ARG A 1 635 ? 95.281  102.436 108.641 1.00 63.74  ? 635 ARG A CA    1 
ATOM 4468 C C     . ARG A 1 635 ? 94.627  103.798 108.868 1.00 60.42  ? 635 ARG A C     1 
ATOM 4469 O O     . ARG A 1 635 ? 94.164  104.464 107.939 1.00 59.40  ? 635 ARG A O     1 
ATOM 4470 C CB    . ARG A 1 635 ? 94.948  101.874 107.256 1.00 65.00  ? 635 ARG A CB    1 
ATOM 4471 C CG    . ARG A 1 635 ? 95.765  100.640 106.877 1.00 64.00  ? 635 ARG A CG    1 
ATOM 4472 C CD    . ARG A 1 635 ? 97.258  100.948 106.799 1.00 67.76  ? 635 ARG A CD    1 
ATOM 4473 N NE    . ARG A 1 635 ? 97.987  100.512 107.985 1.00 70.17  ? 635 ARG A NE    1 
ATOM 4474 C CZ    . ARG A 1 635 ? 98.931  101.222 108.587 1.00 66.36  ? 635 ARG A CZ    1 
ATOM 4475 N NH1   . ARG A 1 635 ? 99.302  102.405 108.128 1.00 58.57  ? 635 ARG A NH1   1 
ATOM 4476 N NH2   . ARG A 1 635 ? 99.516  100.733 109.676 1.00 68.79  ? 635 ARG A NH2   1 
ATOM 4477 N N     . GLN A 1 636 ? 94.595  104.208 110.132 1.00 51.99  ? 636 GLN A N     1 
ATOM 4478 C CA    . GLN A 1 636 ? 94.038  105.491 110.522 1.00 51.25  ? 636 GLN A CA    1 
ATOM 4479 C C     . GLN A 1 636 ? 94.980  106.162 111.509 1.00 51.22  ? 636 GLN A C     1 
ATOM 4480 O O     . GLN A 1 636 ? 95.387  105.553 112.504 1.00 46.66  ? 636 GLN A O     1 
ATOM 4481 C CB    . GLN A 1 636 ? 92.649  105.330 111.139 1.00 53.50  ? 636 GLN A CB    1 
ATOM 4482 C CG    . GLN A 1 636 ? 91.898  106.629 111.271 1.00 52.35  ? 636 GLN A CG    1 
ATOM 4483 C CD    . GLN A 1 636 ? 90.406  106.435 111.413 1.00 53.76  ? 636 GLN A CD    1 
ATOM 4484 O OE1   . GLN A 1 636 ? 89.945  105.379 111.841 1.00 56.38  ? 636 GLN A OE1   1 
ATOM 4485 N NE2   . GLN A 1 636 ? 89.641  107.465 111.074 1.00 51.93  ? 636 GLN A NE2   1 
ATOM 4486 N N     . GLU A 1 637 ? 95.321  107.416 111.225 1.00 49.51  ? 637 GLU A N     1 
ATOM 4487 C CA    . GLU A 1 637 ? 96.258  108.197 112.024 1.00 52.84  ? 637 GLU A CA    1 
ATOM 4488 C C     . GLU A 1 637 ? 95.570  109.416 112.613 1.00 46.93  ? 637 GLU A C     1 
ATOM 4489 O O     . GLU A 1 637 ? 96.071  110.540 112.539 1.00 41.65  ? 637 GLU A O     1 
ATOM 4490 C CB    . GLU A 1 637 ? 97.477  108.598 111.199 1.00 46.86  ? 637 GLU A CB    1 
ATOM 4491 C CG    . GLU A 1 637 ? 98.649  107.664 111.408 1.00 44.13  ? 637 GLU A CG    1 
ATOM 4492 C CD    . GLU A 1 637 ? 98.384  106.284 110.850 1.00 45.46  ? 637 GLU A CD    1 
ATOM 4493 O OE1   . GLU A 1 637 ? 97.859  106.196 109.722 1.00 51.98  ? 637 GLU A OE1   1 
ATOM 4494 O OE2   . GLU A 1 637 ? 98.681  105.290 111.544 1.00 43.55  ? 637 GLU A OE2   1 
ATOM 4495 N N     . ILE A 1 638 ? 94.399  109.203 113.200 1.00 46.87  ? 638 ILE A N     1 
ATOM 4496 C CA    . ILE A 1 638 ? 93.647  110.248 113.875 1.00 44.05  ? 638 ILE A CA    1 
ATOM 4497 C C     . ILE A 1 638 ? 93.405  109.764 115.298 1.00 48.76  ? 638 ILE A C     1 
ATOM 4498 O O     . ILE A 1 638 ? 93.486  108.565 115.582 1.00 53.01  ? 638 ILE A O     1 
ATOM 4499 C CB    . ILE A 1 638 ? 92.322  110.558 113.125 1.00 47.27  ? 638 ILE A CB    1 
ATOM 4500 C CG1   . ILE A 1 638 ? 91.756  111.924 113.496 1.00 42.34  ? 638 ILE A CG1   1 
ATOM 4501 C CG2   . ILE A 1 638 ? 91.245  109.529 113.427 1.00 51.61  ? 638 ILE A CG2   1 
ATOM 4502 C CD1   . ILE A 1 638 ? 92.755  113.015 113.435 1.00 42.26  ? 638 ILE A CD1   1 
ATOM 4503 N N     . ILE A 1 639 ? 93.168  110.699 116.210 1.00 56.80  ? 639 ILE A N     1 
ATOM 4504 C CA    . ILE A 1 639 ? 92.734  110.371 117.561 1.00 58.89  ? 639 ILE A CA    1 
ATOM 4505 C C     . ILE A 1 639 ? 91.264  110.747 117.675 1.00 61.64  ? 639 ILE A C     1 
ATOM 4506 O O     . ILE A 1 639 ? 90.889  111.901 117.433 1.00 63.44  ? 639 ILE A O     1 
ATOM 4507 C CB    . ILE A 1 639 ? 93.585  111.095 118.617 1.00 57.16  ? 639 ILE A CB    1 
ATOM 4508 C CG1   . ILE A 1 639 ? 94.988  110.488 118.691 1.00 52.96  ? 639 ILE A CG1   1 
ATOM 4509 C CG2   . ILE A 1 639 ? 92.917  111.046 119.974 1.00 56.46  ? 639 ILE A CG2   1 
ATOM 4510 C CD1   . ILE A 1 639 ? 95.094  109.202 119.380 1.00 43.12  ? 639 ILE A CD1   1 
ATOM 4511 N N     . GLN A 1 640 ? 90.432  109.770 118.022 1.00 60.83  ? 640 GLN A N     1 
ATOM 4512 C CA    . GLN A 1 640 ? 88.992  109.954 118.101 1.00 58.70  ? 640 GLN A CA    1 
ATOM 4513 C C     . GLN A 1 640 ? 88.415  109.638 119.470 1.00 64.43  ? 640 GLN A C     1 
ATOM 4514 O O     . GLN A 1 640 ? 87.320  110.109 119.785 1.00 70.20  ? 640 GLN A O     1 
ATOM 4515 C CB    . GLN A 1 640 ? 88.287  109.089 117.039 1.00 62.92  ? 640 GLN A CB    1 
ATOM 4516 C CG    . GLN A 1 640 ? 88.198  107.591 117.351 1.00 66.06  ? 640 GLN A CG    1 
ATOM 4517 C CD    . GLN A 1 640 ? 89.511  106.849 117.148 1.00 64.48  ? 640 GLN A CD    1 
ATOM 4518 O OE1   . GLN A 1 640 ? 90.411  106.911 117.987 1.00 66.35  ? 640 GLN A OE1   1 
ATOM 4519 N NE2   . GLN A 1 640 ? 89.625  106.146 116.029 1.00 61.30  ? 640 GLN A NE2   1 
ATOM 4520 N N     . ASP A 1 641 ? 89.124  108.870 120.296 1.00 67.53  ? 641 ASP A N     1 
ATOM 4521 C CA    . ASP A 1 641 ? 88.686  108.543 121.643 1.00 68.50  ? 641 ASP A CA    1 
ATOM 4522 C C     . ASP A 1 641 ? 89.380  109.392 122.694 1.00 62.37  ? 641 ASP A C     1 
ATOM 4523 O O     . ASP A 1 641 ? 89.640  108.897 123.794 1.00 60.38  ? 641 ASP A O     1 
ATOM 4524 C CB    . ASP A 1 641 ? 88.923  107.056 121.927 1.00 64.71  ? 641 ASP A CB    1 
ATOM 4525 C CG    . ASP A 1 641 ? 87.875  106.458 122.856 1.00 65.86  ? 641 ASP A CG    1 
ATOM 4526 O OD1   . ASP A 1 641 ? 86.991  107.204 123.323 1.00 66.07  ? 641 ASP A OD1   1 
ATOM 4527 O OD2   . ASP A 1 641 ? 87.941  105.240 123.123 1.00 66.65  ? 641 ASP A OD2   1 
ATOM 4528 N N     . LEU A 1 642 ? 89.669  110.661 122.379 1.00 52.28  ? 642 LEU A N     1 
ATOM 4529 C CA    . LEU A 1 642 ? 90.487  111.507 123.247 1.00 53.73  ? 642 LEU A CA    1 
ATOM 4530 C C     . LEU A 1 642 ? 89.770  111.889 124.533 1.00 59.35  ? 642 LEU A C     1 
ATOM 4531 O O     . LEU A 1 642 ? 90.428  112.230 125.527 1.00 62.14  ? 642 LEU A O     1 
ATOM 4532 C CB    . LEU A 1 642 ? 90.890  112.780 122.503 1.00 56.53  ? 642 LEU A CB    1 
ATOM 4533 C CG    . LEU A 1 642 ? 92.057  113.618 123.026 1.00 54.30  ? 642 LEU A CG    1 
ATOM 4534 C CD1   . LEU A 1 642 ? 93.197  112.722 123.426 1.00 52.39  ? 642 LEU A CD1   1 
ATOM 4535 C CD2   . LEU A 1 642 ? 92.511  114.625 122.004 1.00 58.70  ? 642 LEU A CD2   1 
ATOM 4536 N N     . ALA A 1 643 ? 88.434  111.845 124.524 1.00 60.06  ? 643 ALA A N     1 
ATOM 4537 C CA    . ALA A 1 643 ? 87.637  112.304 125.656 1.00 60.82  ? 643 ALA A CA    1 
ATOM 4538 C C     . ALA A 1 643 ? 87.872  111.441 126.889 1.00 56.99  ? 643 ALA A C     1 
ATOM 4539 O O     . ALA A 1 643 ? 88.136  111.961 127.978 1.00 57.17  ? 643 ALA A O     1 
ATOM 4540 C CB    . ALA A 1 643 ? 86.156  112.318 125.277 1.00 59.94  ? 643 ALA A CB    1 
ATOM 4541 N N     . ALA A 1 644 ? 87.850  110.116 126.712 1.00 47.20  ? 644 ALA A N     1 
ATOM 4542 C CA    . ALA A 1 644 ? 88.110  109.200 127.818 1.00 46.32  ? 644 ALA A CA    1 
ATOM 4543 C C     . ALA A 1 644 ? 89.556  109.288 128.288 1.00 43.21  ? 644 ALA A C     1 
ATOM 4544 O O     . ALA A 1 644 ? 89.825  109.214 129.497 1.00 48.56  ? 644 ALA A O     1 
ATOM 4545 C CB    . ALA A 1 644 ? 87.769  107.769 127.405 1.00 53.82  ? 644 ALA A CB    1 
ATOM 4546 N N     . MET A 1 645 ? 90.486  109.500 127.346 1.00 36.49  ? 645 MET A N     1 
ATOM 4547 C CA    . MET A 1 645 ? 91.904  109.633 127.674 1.00 36.42  ? 645 MET A CA    1 
ATOM 4548 C C     . MET A 1 645 ? 92.171  110.826 128.574 1.00 45.19  ? 645 MET A C     1 
ATOM 4549 O O     . MET A 1 645 ? 92.566  110.659 129.731 1.00 48.25  ? 645 MET A O     1 
ATOM 4550 C CB    . MET A 1 645 ? 92.747  109.756 126.411 1.00 31.66  ? 645 MET A CB    1 
ATOM 4551 C CG    . MET A 1 645 ? 92.460  108.737 125.381 1.00 41.25  ? 645 MET A CG    1 
ATOM 4552 S SD    . MET A 1 645 ? 93.968  108.286 124.537 1.00 37.27  ? 645 MET A SD    1 
ATOM 4553 C CE    . MET A 1 645 ? 93.321  107.043 123.456 1.00 41.55  ? 645 MET A CE    1 
ATOM 4554 N N     . VAL A 1 646 ? 91.905  112.040 128.082 1.00 46.76  ? 646 VAL A N     1 
ATOM 4555 C CA    . VAL A 1 646 ? 92.244  113.205 128.893 1.00 40.14  ? 646 VAL A CA    1 
ATOM 4556 C C     . VAL A 1 646 ? 91.246  113.400 130.031 1.00 46.06  ? 646 VAL A C     1 
ATOM 4557 O O     . VAL A 1 646 ? 91.550  114.113 130.991 1.00 53.85  ? 646 VAL A O     1 
ATOM 4558 C CB    . VAL A 1 646 ? 92.379  114.471 128.031 1.00 33.71  ? 646 VAL A CB    1 
ATOM 4559 C CG1   . VAL A 1 646 ? 93.402  114.253 126.938 1.00 40.00  ? 646 VAL A CG1   1 
ATOM 4560 C CG2   . VAL A 1 646 ? 91.052  114.873 127.466 1.00 35.08  ? 646 VAL A CG2   1 
ATOM 4561 N N     . ARG A 1 647 ? 90.093  112.717 130.001 1.00 48.22  ? 647 ARG A N     1 
ATOM 4562 C CA    . ARG A 1 647 ? 89.264  112.616 131.195 1.00 43.51  ? 647 ARG A CA    1 
ATOM 4563 C C     . ARG A 1 647 ? 89.991  111.865 132.301 1.00 43.77  ? 647 ARG A C     1 
ATOM 4564 O O     . ARG A 1 647 ? 90.063  112.347 133.439 1.00 51.24  ? 647 ARG A O     1 
ATOM 4565 C CB    . ARG A 1 647 ? 87.938  111.933 130.853 1.00 48.24  ? 647 ARG A CB    1 
ATOM 4566 C CG    . ARG A 1 647 ? 86.736  112.867 130.857 1.00 48.96  ? 647 ARG A CG    1 
ATOM 4567 C CD    . ARG A 1 647 ? 85.442  112.092 130.666 1.00 48.37  ? 647 ARG A CD    1 
ATOM 4568 N NE    . ARG A 1 647 ? 85.320  110.987 131.610 1.00 45.13  ? 647 ARG A NE    1 
ATOM 4569 C CZ    . ARG A 1 647 ? 84.857  111.103 132.847 1.00 45.23  ? 647 ARG A CZ    1 
ATOM 4570 N NH1   . ARG A 1 647 ? 84.451  112.266 133.327 1.00 48.40  ? 647 ARG A NH1   1 
ATOM 4571 N NH2   . ARG A 1 647 ? 84.799  110.023 133.621 1.00 49.02  ? 647 ARG A NH2   1 
ATOM 4572 N N     . GLU A 1 648 ? 90.581  110.708 131.968 1.00 43.07  ? 648 GLU A N     1 
ATOM 4573 C CA    . GLU A 1 648 ? 91.358  109.956 132.951 1.00 46.70  ? 648 GLU A CA    1 
ATOM 4574 C C     . GLU A 1 648 ? 92.594  110.731 133.394 1.00 39.48  ? 648 GLU A C     1 
ATOM 4575 O O     . GLU A 1 648 ? 92.946  110.720 134.580 1.00 42.23  ? 648 GLU A O     1 
ATOM 4576 C CB    . GLU A 1 648 ? 91.760  108.594 132.381 1.00 42.75  ? 648 GLU A CB    1 
ATOM 4577 C CG    . GLU A 1 648 ? 92.254  107.597 133.430 1.00 42.07  ? 648 GLU A CG    1 
ATOM 4578 C CD    . GLU A 1 648 ? 93.742  107.703 133.695 1.00 49.03  ? 648 GLU A CD    1 
ATOM 4579 O OE1   . GLU A 1 648 ? 94.483  108.066 132.762 1.00 53.75  ? 648 GLU A OE1   1 
ATOM 4580 O OE2   . GLU A 1 648 ? 94.157  107.489 134.850 1.00 52.85  ? 648 GLU A OE2   1 
ATOM 4581 N N     . LEU A 1 649 ? 93.245  111.421 132.456 1.00 29.01  ? 649 LEU A N     1 
ATOM 4582 C CA    . LEU A 1 649 ? 94.467  112.164 132.763 1.00 46.90  ? 649 LEU A CA    1 
ATOM 4583 C C     . LEU A 1 649 ? 94.196  113.344 133.696 1.00 51.15  ? 649 LEU A C     1 
ATOM 4584 O O     . LEU A 1 649 ? 94.942  113.574 134.657 1.00 43.61  ? 649 LEU A O     1 
ATOM 4585 C CB    . LEU A 1 649 ? 95.115  112.644 131.468 1.00 46.33  ? 649 LEU A CB    1 
ATOM 4586 C CG    . LEU A 1 649 ? 95.572  111.497 130.578 1.00 43.45  ? 649 LEU A CG    1 
ATOM 4587 C CD1   . LEU A 1 649 ? 95.858  111.963 129.187 1.00 42.10  ? 649 LEU A CD1   1 
ATOM 4588 C CD2   . LEU A 1 649 ? 96.761  110.832 131.150 1.00 37.89  ? 649 LEU A CD2   1 
ATOM 4589 N N     . LEU A 1 650 ? 93.112  114.084 133.457 1.00 47.12  ? 650 LEU A N     1 
ATOM 4590 C CA    . LEU A 1 650 ? 92.860  115.236 134.309 1.00 35.09  ? 650 LEU A CA    1 
ATOM 4591 C C     . LEU A 1 650 ? 92.217  114.849 135.640 1.00 36.74  ? 650 LEU A C     1 
ATOM 4592 O O     . LEU A 1 650 ? 92.476  115.520 136.647 1.00 35.68  ? 650 LEU A O     1 
ATOM 4593 C CB    . LEU A 1 650 ? 92.028  116.279 133.558 1.00 37.18  ? 650 LEU A CB    1 
ATOM 4594 C CG    . LEU A 1 650 ? 92.675  116.884 132.296 1.00 39.68  ? 650 LEU A CG    1 
ATOM 4595 C CD1   . LEU A 1 650 ? 91.945  118.127 131.831 1.00 41.70  ? 650 LEU A CD1   1 
ATOM 4596 C CD2   . LEU A 1 650 ? 94.156  117.170 132.451 1.00 35.09  ? 650 LEU A CD2   1 
ATOM 4597 N N     . ILE A 1 651 ? 91.430  113.759 135.705 1.00 45.57  ? 651 ILE A N     1 
ATOM 4598 C CA    . ILE A 1 651 ? 90.998  113.287 137.025 1.00 47.06  ? 651 ILE A CA    1 
ATOM 4599 C C     . ILE A 1 651 ? 92.166  112.690 137.803 1.00 43.46  ? 651 ILE A C     1 
ATOM 4600 O O     . ILE A 1 651 ? 92.192  112.754 139.038 1.00 50.71  ? 651 ILE A O     1 
ATOM 4601 C CB    . ILE A 1 651 ? 89.799  112.310 136.949 1.00 47.90  ? 651 ILE A CB    1 
ATOM 4602 C CG1   . ILE A 1 651 ? 90.189  110.909 136.454 1.00 42.19  ? 651 ILE A CG1   1 
ATOM 4603 C CG2   . ILE A 1 651 ? 88.579  112.934 136.277 1.00 47.94  ? 651 ILE A CG2   1 
ATOM 4604 C CD1   . ILE A 1 651 ? 89.161  109.846 136.761 1.00 37.33  ? 651 ILE A CD1   1 
ATOM 4605 N N     . GLN A 1 652 ? 93.180  112.158 137.112 1.00 32.26  ? 652 GLN A N     1 
ATOM 4606 C CA    . GLN A 1 652 ? 94.318  111.661 137.868 1.00 32.46  ? 652 GLN A CA    1 
ATOM 4607 C C     . GLN A 1 652 ? 95.222  112.810 138.301 1.00 41.73  ? 652 GLN A C     1 
ATOM 4608 O O     . GLN A 1 652 ? 95.888  112.708 139.335 1.00 49.44  ? 652 GLN A O     1 
ATOM 4609 C CB    . GLN A 1 652 ? 95.103  110.633 137.059 1.00 35.16  ? 652 GLN A CB    1 
ATOM 4610 C CG    . GLN A 1 652 ? 95.007  109.183 137.576 1.00 37.43  ? 652 GLN A CG    1 
ATOM 4611 C CD    . GLN A 1 652 ? 95.366  108.946 139.046 1.00 41.29  ? 652 GLN A CD    1 
ATOM 4612 O OE1   . GLN A 1 652 ? 96.131  109.683 139.666 1.00 39.98  ? 652 GLN A OE1   1 
ATOM 4613 N NE2   . GLN A 1 652 ? 94.792  107.888 139.607 1.00 41.52  ? 652 GLN A NE2   1 
ATOM 4614 N N     . PHE A 1 653 ? 95.232  113.915 137.542 1.00 37.71  ? 653 PHE A N     1 
ATOM 4615 C CA    . PHE A 1 653 ? 95.869  115.155 138.000 1.00 34.93  ? 653 PHE A CA    1 
ATOM 4616 C C     . PHE A 1 653 ? 95.180  115.700 139.247 1.00 37.34  ? 653 PHE A C     1 
ATOM 4617 O O     . PHE A 1 653 ? 95.843  116.144 140.196 1.00 33.84  ? 653 PHE A O     1 
ATOM 4618 C CB    . PHE A 1 653 ? 95.839  116.195 136.873 1.00 39.64  ? 653 PHE A CB    1 
ATOM 4619 C CG    . PHE A 1 653 ? 96.949  117.231 136.934 1.00 44.33  ? 653 PHE A CG    1 
ATOM 4620 C CD1   . PHE A 1 653 ? 96.967  118.216 137.915 1.00 43.19  ? 653 PHE A CD1   1 
ATOM 4621 C CD2   . PHE A 1 653 ? 97.956  117.234 135.987 1.00 49.47  ? 653 PHE A CD2   1 
ATOM 4622 C CE1   . PHE A 1 653 ? 97.973  119.168 137.956 1.00 39.37  ? 653 PHE A CE1   1 
ATOM 4623 C CE2   . PHE A 1 653 ? 98.964  118.187 136.022 1.00 39.61  ? 653 PHE A CE2   1 
ATOM 4624 C CZ    . PHE A 1 653 ? 98.972  119.148 137.009 1.00 34.64  ? 653 PHE A CZ    1 
ATOM 4625 N N     . TYR A 1 654 ? 93.844  115.692 139.245 1.00 49.55  ? 654 TYR A N     1 
ATOM 4626 C CA    . TYR A 1 654 ? 93.069  116.153 140.393 1.00 48.51  ? 654 TYR A CA    1 
ATOM 4627 C C     . TYR A 1 654 ? 93.285  115.255 141.605 1.00 46.58  ? 654 TYR A C     1 
ATOM 4628 O O     . TYR A 1 654 ? 93.279  115.719 142.749 1.00 49.12  ? 654 TYR A O     1 
ATOM 4629 C CB    . TYR A 1 654 ? 91.588  116.200 140.023 1.00 50.61  ? 654 TYR A CB    1 
ATOM 4630 C CG    . TYR A 1 654 ? 90.727  117.012 140.959 1.00 52.99  ? 654 TYR A CG    1 
ATOM 4631 C CD1   . TYR A 1 654 ? 91.257  118.071 141.687 1.00 52.92  ? 654 TYR A CD1   1 
ATOM 4632 C CD2   . TYR A 1 654 ? 89.371  116.732 141.095 1.00 52.06  ? 654 TYR A CD2   1 
ATOM 4633 C CE1   . TYR A 1 654 ? 90.464  118.817 142.538 1.00 52.72  ? 654 TYR A CE1   1 
ATOM 4634 C CE2   . TYR A 1 654 ? 88.571  117.469 141.946 1.00 54.19  ? 654 TYR A CE2   1 
ATOM 4635 C CZ    . TYR A 1 654 ? 89.122  118.510 142.663 1.00 55.36  ? 654 TYR A CZ    1 
ATOM 4636 O OH    . TYR A 1 654 ? 88.326  119.246 143.508 1.00 57.13  ? 654 TYR A OH    1 
ATOM 4637 N N     . LYS A 1 655 ? 93.464  113.955 141.368 1.00 41.82  ? 655 LYS A N     1 
ATOM 4638 C CA    . LYS A 1 655 ? 93.797  113.040 142.453 1.00 43.49  ? 655 LYS A CA    1 
ATOM 4639 C C     . LYS A 1 655 ? 95.231  113.253 142.934 1.00 46.46  ? 655 LYS A C     1 
ATOM 4640 O O     . LYS A 1 655 ? 95.533  113.073 144.119 1.00 45.63  ? 655 LYS A O     1 
ATOM 4641 C CB    . LYS A 1 655 ? 93.581  111.600 141.985 1.00 38.76  ? 655 LYS A CB    1 
ATOM 4642 C CG    . LYS A 1 655 ? 93.749  110.534 143.049 1.00 37.97  ? 655 LYS A CG    1 
ATOM 4643 C CD    . LYS A 1 655 ? 92.504  109.675 143.137 1.00 43.45  ? 655 LYS A CD    1 
ATOM 4644 C CE    . LYS A 1 655 ? 92.327  108.850 141.876 1.00 47.47  ? 655 LYS A CE    1 
ATOM 4645 N NZ    . LYS A 1 655 ? 91.040  108.105 141.881 1.00 50.37  ? 655 LYS A NZ    1 
ATOM 4646 N N     . SER A 1 656 ? 96.125  113.655 142.027 1.00 36.46  ? 656 SER A N     1 
ATOM 4647 C CA    . SER A 1 656 ? 97.538  113.763 142.371 1.00 30.10  ? 656 SER A CA    1 
ATOM 4648 C C     . SER A 1 656 ? 97.835  115.013 143.185 1.00 39.25  ? 656 SER A C     1 
ATOM 4649 O O     . SER A 1 656 ? 98.479  114.930 144.237 1.00 45.41  ? 656 SER A O     1 
ATOM 4650 C CB    . SER A 1 656 ? 98.382  113.751 141.101 1.00 36.94  ? 656 SER A CB    1 
ATOM 4651 O OG    . SER A 1 656 ? 99.742  113.993 141.402 1.00 40.34  ? 656 SER A OG    1 
ATOM 4652 N N     . THR A 1 657 ? 97.383  116.183 142.725 1.00 51.18  ? 657 THR A N     1 
ATOM 4653 C CA    . THR A 1 657 ? 97.789  117.431 143.361 1.00 52.00  ? 657 THR A CA    1 
ATOM 4654 C C     . THR A 1 657 ? 96.672  118.185 144.065 1.00 51.92  ? 657 THR A C     1 
ATOM 4655 O O     . THR A 1 657 ? 96.979  119.142 144.786 1.00 52.53  ? 657 THR A O     1 
ATOM 4656 C CB    . THR A 1 657 ? 98.430  118.383 142.338 1.00 51.22  ? 657 THR A CB    1 
ATOM 4657 O OG1   . THR A 1 657 ? 97.650  118.398 141.138 1.00 54.61  ? 657 THR A OG1   1 
ATOM 4658 C CG2   . THR A 1 657 ? 99.847  117.940 142.017 1.00 55.34  ? 657 THR A CG2   1 
ATOM 4659 N N     . ARG A 1 658 ? 95.410  117.764 143.896 1.00 59.03  ? 658 ARG A N     1 
ATOM 4660 C CA    . ARG A 1 658 ? 94.201  118.488 144.326 1.00 57.14  ? 658 ARG A CA    1 
ATOM 4661 C C     . ARG A 1 658 ? 94.220  119.910 143.751 1.00 58.20  ? 658 ARG A C     1 
ATOM 4662 O O     . ARG A 1 658 ? 94.008  120.912 144.437 1.00 61.54  ? 658 ARG A O     1 
ATOM 4663 C CB    . ARG A 1 658 ? 94.041  118.455 145.861 1.00 54.70  ? 658 ARG A CB    1 
ATOM 4664 C CG    . ARG A 1 658 ? 92.665  118.846 146.461 1.00 51.47  ? 658 ARG A CG    1 
ATOM 4665 C CD    . ARG A 1 658 ? 91.474  118.029 145.920 1.00 53.58  ? 658 ARG A CD    1 
ATOM 4666 N NE    . ARG A 1 658 ? 91.731  116.614 145.648 1.00 58.05  ? 658 ARG A NE    1 
ATOM 4667 C CZ    . ARG A 1 658 ? 91.967  115.676 146.559 1.00 58.28  ? 658 ARG A CZ    1 
ATOM 4668 N NH1   . ARG A 1 658 ? 91.909  115.932 147.857 1.00 61.00  ? 658 ARG A NH1   1 
ATOM 4669 N NH2   . ARG A 1 658 ? 92.243  114.439 146.157 1.00 50.03  ? 658 ARG A NH2   1 
ATOM 4670 N N     . PHE A 1 659 ? 94.529  119.982 142.459 1.00 54.37  ? 659 PHE A N     1 
ATOM 4671 C CA    . PHE A 1 659 ? 94.660  121.252 141.757 1.00 56.09  ? 659 PHE A CA    1 
ATOM 4672 C C     . PHE A 1 659 ? 94.443  121.009 140.275 1.00 54.86  ? 659 PHE A C     1 
ATOM 4673 O O     . PHE A 1 659 ? 95.220  120.287 139.646 1.00 57.02  ? 659 PHE A O     1 
ATOM 4674 C CB    . PHE A 1 659 ? 96.032  121.880 142.001 1.00 53.75  ? 659 PHE A CB    1 
ATOM 4675 C CG    . PHE A 1 659 ? 96.016  122.981 143.014 1.00 51.52  ? 659 PHE A CG    1 
ATOM 4676 C CD1   . PHE A 1 659 ? 95.087  124.005 142.921 1.00 50.96  ? 659 PHE A CD1   1 
ATOM 4677 C CD2   . PHE A 1 659 ? 96.923  122.991 144.061 1.00 51.75  ? 659 PHE A CD2   1 
ATOM 4678 C CE1   . PHE A 1 659 ? 95.064  125.023 143.852 1.00 57.01  ? 659 PHE A CE1   1 
ATOM 4679 C CE2   . PHE A 1 659 ? 96.907  124.006 144.999 1.00 52.82  ? 659 PHE A CE2   1 
ATOM 4680 C CZ    . PHE A 1 659 ? 95.975  125.024 144.894 1.00 54.35  ? 659 PHE A CZ    1 
ATOM 4681 N N     . LYS A 1 660 ? 93.395  121.609 139.730 1.00 54.93  ? 660 LYS A N     1 
ATOM 4682 C CA    . LYS A 1 660 ? 93.134  121.542 138.304 1.00 53.14  ? 660 LYS A CA    1 
ATOM 4683 C C     . LYS A 1 660 ? 94.191  122.357 137.567 1.00 61.01  ? 660 LYS A C     1 
ATOM 4684 O O     . LYS A 1 660 ? 94.384  123.539 137.893 1.00 56.31  ? 660 LYS A O     1 
ATOM 4685 C CB    . LYS A 1 660 ? 91.740  122.079 137.994 1.00 51.88  ? 660 LYS A CB    1 
ATOM 4686 C CG    . LYS A 1 660 ? 90.767  122.008 139.161 1.00 52.65  ? 660 LYS A CG    1 
ATOM 4687 C CD    . LYS A 1 660 ? 89.447  122.696 138.833 1.00 56.51  ? 660 LYS A CD    1 
ATOM 4688 C CE    . LYS A 1 660 ? 89.647  124.163 138.479 1.00 57.10  ? 660 LYS A CE    1 
ATOM 4689 N NZ    . LYS A 1 660 ? 90.413  124.900 139.520 1.00 57.90  ? 660 LYS A NZ    1 
ATOM 4690 N N     . PRO A 1 661 ? 94.909  121.773 136.606 1.00 63.06  ? 661 PRO A N     1 
ATOM 4691 C CA    . PRO A 1 661 ? 95.977  122.516 135.922 1.00 63.74  ? 661 PRO A CA    1 
ATOM 4692 C C     . PRO A 1 661 ? 95.415  123.588 135.000 1.00 59.15  ? 661 PRO A C     1 
ATOM 4693 O O     . PRO A 1 661 ? 94.295  123.477 134.498 1.00 61.75  ? 661 PRO A O     1 
ATOM 4694 C CB    . PRO A 1 661 ? 96.732  121.434 135.143 1.00 51.52  ? 661 PRO A CB    1 
ATOM 4695 C CG    . PRO A 1 661 ? 95.852  120.250 135.117 1.00 36.48  ? 661 PRO A CG    1 
ATOM 4696 C CD    . PRO A 1 661 ? 94.744  120.404 136.092 1.00 45.16  ? 661 PRO A CD    1 
ATOM 4697 N N     . THR A 1 662 ? 96.208  124.635 134.783 1.00 61.40  ? 662 THR A N     1 
ATOM 4698 C CA    . THR A 1 662 ? 95.737  125.819 134.082 1.00 69.59  ? 662 THR A CA    1 
ATOM 4699 C C     . THR A 1 662 ? 96.290  125.937 132.665 1.00 72.95  ? 662 THR A C     1 
ATOM 4700 O O     . THR A 1 662 ? 95.696  126.640 131.839 1.00 73.09  ? 662 THR A O     1 
ATOM 4701 C CB    . THR A 1 662 ? 96.108  127.071 134.891 1.00 69.37  ? 662 THR A CB    1 
ATOM 4702 O OG1   . THR A 1 662 ? 96.033  126.761 136.285 1.00 63.69  ? 662 THR A OG1   1 
ATOM 4703 C CG2   . THR A 1 662 ? 95.133  128.213 134.626 1.00 66.26  ? 662 THR A CG2   1 
ATOM 4704 N N     . ARG A 1 663 ? 97.402  125.271 132.354 1.00 57.89  ? 663 ARG A N     1 
ATOM 4705 C CA    . ARG A 1 663 ? 98.028  125.384 131.039 1.00 53.08  ? 663 ARG A CA    1 
ATOM 4706 C C     . ARG A 1 663 ? 98.238  123.995 130.460 1.00 49.73  ? 663 ARG A C     1 
ATOM 4707 O O     . ARG A 1 663 ? 98.923  123.173 131.074 1.00 44.00  ? 663 ARG A O     1 
ATOM 4708 C CB    . ARG A 1 663 ? 99.367  126.122 131.124 1.00 59.23  ? 663 ARG A CB    1 
ATOM 4709 C CG    . ARG A 1 663 ? 99.304  127.489 131.785 1.00 54.34  ? 663 ARG A CG    1 
ATOM 4710 C CD    . ARG A 1 663 ? 98.792  128.551 130.830 1.00 55.00  ? 663 ARG A CD    1 
ATOM 4711 N NE    . ARG A 1 663 ? 98.959  129.890 131.378 1.00 55.86  ? 663 ARG A NE    1 
ATOM 4712 C CZ    . ARG A 1 663 ? 100.080 130.593 131.304 1.00 56.09  ? 663 ARG A CZ    1 
ATOM 4713 N NH1   . ARG A 1 663 ? 101.155 130.117 130.700 1.00 60.70  ? 663 ARG A NH1   1 
ATOM 4714 N NH2   . ARG A 1 663 ? 100.124 131.803 131.852 1.00 50.31  ? 663 ARG A NH2   1 
ATOM 4715 N N     . ILE A 1 664 ? 97.681  123.747 129.272 1.00 52.85  ? 664 ILE A N     1 
ATOM 4716 C CA    . ILE A 1 664 ? 97.872  122.479 128.570 1.00 53.79  ? 664 ILE A CA    1 
ATOM 4717 C C     . ILE A 1 664 ? 99.021  122.615 127.585 1.00 51.22  ? 664 ILE A C     1 
ATOM 4718 O O     . ILE A 1 664 ? 99.030  123.523 126.748 1.00 44.71  ? 664 ILE A O     1 
ATOM 4719 C CB    . ILE A 1 664 ? 96.593  122.038 127.839 1.00 50.70  ? 664 ILE A CB    1 
ATOM 4720 C CG1   . ILE A 1 664 ? 95.370  122.089 128.749 1.00 56.31  ? 664 ILE A CG1   1 
ATOM 4721 C CG2   . ILE A 1 664 ? 96.771  120.646 127.269 1.00 46.82  ? 664 ILE A CG2   1 
ATOM 4722 C CD1   . ILE A 1 664 ? 94.094  121.724 128.024 1.00 58.97  ? 664 ILE A CD1   1 
ATOM 4723 N N     . ILE A 1 665 ? 99.978  121.704 127.667 1.00 46.56  ? 665 ILE A N     1 
ATOM 4724 C CA    . ILE A 1 665 ? 101.102 121.661 126.739 1.00 30.51  ? 665 ILE A CA    1 
ATOM 4725 C C     . ILE A 1 665 ? 101.008 120.327 126.009 1.00 32.77  ? 665 ILE A C     1 
ATOM 4726 O O     . ILE A 1 665 ? 101.518 119.311 126.480 1.00 47.95  ? 665 ILE A O     1 
ATOM 4727 C CB    . ILE A 1 665 ? 102.449 121.828 127.446 1.00 20.55  ? 665 ILE A CB    1 
ATOM 4728 C CG1   . ILE A 1 665 ? 102.399 123.026 128.404 1.00 32.92  ? 665 ILE A CG1   1 
ATOM 4729 C CG2   . ILE A 1 665 ? 103.540 122.006 126.423 1.00 34.48  ? 665 ILE A CG2   1 
ATOM 4730 C CD1   . ILE A 1 665 ? 103.741 123.534 128.886 1.00 45.17  ? 665 ILE A CD1   1 
ATOM 4731 N N     . PHE A 1 666 ? 100.355 120.328 124.848 1.00 11.53  ? 666 PHE A N     1 
ATOM 4732 C CA    . PHE A 1 666 ? 100.089 119.130 124.063 1.00 21.82  ? 666 PHE A CA    1 
ATOM 4733 C C     . PHE A 1 666 ? 101.261 118.832 123.125 1.00 19.62  ? 666 PHE A C     1 
ATOM 4734 O O     . PHE A 1 666 ? 101.979 119.731 122.682 1.00 22.54  ? 666 PHE A O     1 
ATOM 4735 C CB    . PHE A 1 666 ? 98.789  119.318 123.269 1.00 27.12  ? 666 PHE A CB    1 
ATOM 4736 C CG    . PHE A 1 666 ? 98.065  118.034 122.898 1.00 23.88  ? 666 PHE A CG    1 
ATOM 4737 C CD1   . PHE A 1 666 ? 98.419  116.810 123.437 1.00 25.33  ? 666 PHE A CD1   1 
ATOM 4738 C CD2   . PHE A 1 666 ? 97.005  118.075 122.004 1.00 24.01  ? 666 PHE A CD2   1 
ATOM 4739 C CE1   . PHE A 1 666 ? 97.749  115.662 123.096 1.00 27.14  ? 666 PHE A CE1   1 
ATOM 4740 C CE2   . PHE A 1 666 ? 96.333  116.925 121.648 1.00 30.10  ? 666 PHE A CE2   1 
ATOM 4741 C CZ    . PHE A 1 666 ? 96.704  115.718 122.199 1.00 32.57  ? 666 PHE A CZ    1 
ATOM 4742 N N     . TYR A 1 667 ? 101.455 117.546 122.831 1.00 21.73  ? 667 TYR A N     1 
ATOM 4743 C CA    . TYR A 1 667 ? 102.497 117.097 121.921 1.00 19.53  ? 667 TYR A CA    1 
ATOM 4744 C C     . TYR A 1 667 ? 101.968 115.959 121.067 1.00 33.81  ? 667 TYR A C     1 
ATOM 4745 O O     . TYR A 1 667 ? 100.999 115.289 121.431 1.00 44.98  ? 667 TYR A O     1 
ATOM 4746 C CB    . TYR A 1 667 ? 103.727 116.626 122.679 1.00 11.16  ? 667 TYR A CB    1 
ATOM 4747 C CG    . TYR A 1 667 ? 104.554 117.756 123.165 1.00 4.89   ? 667 TYR A CG    1 
ATOM 4748 C CD1   . TYR A 1 667 ? 105.420 118.417 122.321 1.00 13.86  ? 667 TYR A CD1   1 
ATOM 4749 C CD2   . TYR A 1 667 ? 104.436 118.195 124.467 1.00 19.30  ? 667 TYR A CD2   1 
ATOM 4750 C CE1   . TYR A 1 667 ? 106.166 119.465 122.775 1.00 23.61  ? 667 TYR A CE1   1 
ATOM 4751 C CE2   . TYR A 1 667 ? 105.184 119.228 124.934 1.00 22.73  ? 667 TYR A CE2   1 
ATOM 4752 C CZ    . TYR A 1 667 ? 106.032 119.878 124.080 1.00 24.45  ? 667 TYR A CZ    1 
ATOM 4753 O OH    . TYR A 1 667 ? 106.787 120.924 124.549 1.00 25.24  ? 667 TYR A OH    1 
ATOM 4754 N N     . ARG A 1 668 ? 102.618 115.750 119.919 1.00 11.64  ? 668 ARG A N     1 
ATOM 4755 C CA    . ARG A 1 668 ? 102.445 114.534 119.131 1.00 12.22  ? 668 ARG A CA    1 
ATOM 4756 C C     . ARG A 1 668 ? 103.640 114.284 118.229 1.00 15.86  ? 668 ARG A C     1 
ATOM 4757 O O     . ARG A 1 668 ? 104.039 115.171 117.476 1.00 30.19  ? 668 ARG A O     1 
ATOM 4758 C CB    . ARG A 1 668 ? 101.175 114.578 118.280 1.00 16.09  ? 668 ARG A CB    1 
ATOM 4759 C CG    . ARG A 1 668 ? 100.902 113.266 117.522 1.00 25.36  ? 668 ARG A CG    1 
ATOM 4760 C CD    . ARG A 1 668 ? 99.429  112.916 117.433 1.00 22.39  ? 668 ARG A CD    1 
ATOM 4761 N NE    . ARG A 1 668 ? 98.614  114.120 117.434 1.00 27.86  ? 668 ARG A NE    1 
ATOM 4762 C CZ    . ARG A 1 668 ? 98.285  114.818 116.356 1.00 37.28  ? 668 ARG A CZ    1 
ATOM 4763 N NH1   . ARG A 1 668 ? 98.628  114.427 115.141 1.00 29.29  ? 668 ARG A NH1   1 
ATOM 4764 N NH2   . ARG A 1 668 ? 97.589  115.935 116.506 1.00 36.45  ? 668 ARG A NH2   1 
ATOM 4765 N N     . ALA A 1 669 ? 104.184 113.072 118.265 1.00 17.94  ? 669 ALA A N     1 
ATOM 4766 C CA    . ALA A 1 669 ? 105.347 112.715 117.469 1.00 17.76  ? 669 ALA A CA    1 
ATOM 4767 C C     . ALA A 1 669 ? 104.927 112.026 116.178 1.00 22.34  ? 669 ALA A C     1 
ATOM 4768 O O     . ALA A 1 669 ? 104.007 111.203 116.171 1.00 27.99  ? 669 ALA A O     1 
ATOM 4769 C CB    . ALA A 1 669 ? 106.291 111.805 118.255 1.00 29.55  ? 669 ALA A CB    1 
ATOM 4770 N N     . GLY A 1 670 ? 105.604 112.382 115.086 1.00 29.87  ? 670 GLY A N     1 
ATOM 4771 C CA    . GLY A 1 670 ? 105.481 111.679 113.822 1.00 37.80  ? 670 GLY A CA    1 
ATOM 4772 C C     . GLY A 1 670 ? 104.153 111.821 113.110 1.00 40.24  ? 670 GLY A C     1 
ATOM 4773 O O     . GLY A 1 670 ? 103.402 110.848 112.988 1.00 38.98  ? 670 GLY A O     1 
ATOM 4774 N N     . VAL A 1 671 ? 103.844 113.027 112.640 1.00 41.98  ? 671 VAL A N     1 
ATOM 4775 C CA    . VAL A 1 671 ? 102.611 113.308 111.912 1.00 38.27  ? 671 VAL A CA    1 
ATOM 4776 C C     . VAL A 1 671 ? 102.984 113.728 110.496 1.00 43.89  ? 671 VAL A C     1 
ATOM 4777 O O     . VAL A 1 671 ? 104.022 114.367 110.286 1.00 42.60  ? 671 VAL A O     1 
ATOM 4778 C CB    . VAL A 1 671 ? 101.773 114.400 112.605 1.00 28.69  ? 671 VAL A CB    1 
ATOM 4779 C CG1   . VAL A 1 671 ? 100.318 114.334 112.170 1.00 32.50  ? 671 VAL A CG1   1 
ATOM 4780 C CG2   . VAL A 1 671 ? 101.864 114.267 114.092 1.00 19.78  ? 671 VAL A CG2   1 
ATOM 4781 N N     . SER A 1 672 ? 102.159 113.339 109.527 1.00 36.17  ? 672 SER A N     1 
ATOM 4782 C CA    . SER A 1 672 ? 102.320 113.820 108.163 1.00 30.05  ? 672 SER A CA    1 
ATOM 4783 C C     . SER A 1 672 ? 101.965 115.297 108.078 1.00 23.09  ? 672 SER A C     1 
ATOM 4784 O O     . SER A 1 672 ? 101.149 115.800 108.853 1.00 29.42  ? 672 SER A O     1 
ATOM 4785 C CB    . SER A 1 672 ? 101.443 113.014 107.212 1.00 37.55  ? 672 SER A CB    1 
ATOM 4786 O OG    . SER A 1 672 ? 100.144 112.850 107.749 1.00 43.28  ? 672 SER A OG    1 
ATOM 4787 N N     . GLU A 1 673 ? 102.579 115.988 107.118 1.00 27.41  ? 673 GLU A N     1 
ATOM 4788 C CA    . GLU A 1 673 ? 102.456 117.441 107.034 1.00 35.88  ? 673 GLU A CA    1 
ATOM 4789 C C     . GLU A 1 673 ? 101.093 117.858 106.493 1.00 32.76  ? 673 GLU A C     1 
ATOM 4790 O O     . GLU A 1 673 ? 100.621 118.969 106.756 1.00 25.62  ? 673 GLU A O     1 
ATOM 4791 C CB    . GLU A 1 673 ? 103.575 118.038 106.167 1.00 29.62  ? 673 GLU A CB    1 
ATOM 4792 C CG    . GLU A 1 673 ? 105.042 117.832 106.624 1.00 27.64  ? 673 GLU A CG    1 
ATOM 4793 C CD    . GLU A 1 673 ? 105.581 116.418 106.453 1.00 36.23  ? 673 GLU A CD    1 
ATOM 4794 O OE1   . GLU A 1 673 ? 106.458 116.017 107.244 1.00 29.93  ? 673 GLU A OE1   1 
ATOM 4795 O OE2   . GLU A 1 673 ? 105.121 115.710 105.534 1.00 46.94  ? 673 GLU A OE2   1 
ATOM 4796 N N     . GLY A 1 674 ? 100.454 116.987 105.715 1.00 30.71  ? 674 GLY A N     1 
ATOM 4797 C CA    . GLY A 1 674 ? 99.155  117.316 105.157 1.00 35.53  ? 674 GLY A CA    1 
ATOM 4798 C C     . GLY A 1 674 ? 97.966  117.021 106.046 1.00 34.58  ? 674 GLY A C     1 
ATOM 4799 O O     . GLY A 1 674 ? 96.847  117.414 105.706 1.00 42.63  ? 674 GLY A O     1 
ATOM 4800 N N     . GLN A 1 675 ? 98.178  116.351 107.176 1.00 31.25  ? 675 GLN A N     1 
ATOM 4801 C CA    . GLN A 1 675 ? 97.095  115.908 108.043 1.00 38.68  ? 675 GLN A CA    1 
ATOM 4802 C C     . GLN A 1 675 ? 96.826  116.879 109.188 1.00 33.19  ? 675 GLN A C     1 
ATOM 4803 O O     . GLN A 1 675 ? 96.075  116.536 110.111 1.00 31.61  ? 675 GLN A O     1 
ATOM 4804 C CB    . GLN A 1 675 ? 97.424  114.519 108.610 1.00 36.05  ? 675 GLN A CB    1 
ATOM 4805 C CG    . GLN A 1 675 ? 96.242  113.564 108.755 1.00 38.10  ? 675 GLN A CG    1 
ATOM 4806 C CD    . GLN A 1 675 ? 95.659  113.139 107.420 1.00 38.27  ? 675 GLN A CD    1 
ATOM 4807 O OE1   . GLN A 1 675 ? 94.798  113.813 106.859 1.00 36.13  ? 675 GLN A OE1   1 
ATOM 4808 N NE2   . GLN A 1 675 ? 96.119  112.003 106.911 1.00 32.43  ? 675 GLN A NE2   1 
ATOM 4809 N N     . PHE A 1 676 ? 97.425  118.072 109.144 1.00 13.27  ? 676 PHE A N     1 
ATOM 4810 C CA    . PHE A 1 676 ? 97.468  118.937 110.318 1.00 4.10   ? 676 PHE A CA    1 
ATOM 4811 C C     . PHE A 1 676 ? 96.115  119.553 110.630 1.00 13.34  ? 676 PHE A C     1 
ATOM 4812 O O     . PHE A 1 676 ? 95.754  119.694 111.802 1.00 29.25  ? 676 PHE A O     1 
ATOM 4813 C CB    . PHE A 1 676 ? 98.522  120.023 110.135 1.00 27.17  ? 676 PHE A CB    1 
ATOM 4814 C CG    . PHE A 1 676 ? 99.925  119.568 110.434 1.00 20.02  ? 676 PHE A CG    1 
ATOM 4815 C CD1   . PHE A 1 676 ? 100.169 118.308 110.963 1.00 4.69   ? 676 PHE A CD1   1 
ATOM 4816 C CD2   . PHE A 1 676 ? 100.998 120.412 110.200 1.00 22.11  ? 676 PHE A CD2   1 
ATOM 4817 C CE1   . PHE A 1 676 ? 101.450 117.901 111.238 1.00 4.67   ? 676 PHE A CE1   1 
ATOM 4818 C CE2   . PHE A 1 676 ? 102.280 120.005 110.474 1.00 22.13  ? 676 PHE A CE2   1 
ATOM 4819 C CZ    . PHE A 1 676 ? 102.502 118.750 110.990 1.00 15.47  ? 676 PHE A CZ    1 
ATOM 4820 N N     . GLN A 1 677 ? 95.344  119.906 109.600 1.00 32.16  ? 677 GLN A N     1 
ATOM 4821 C CA    . GLN A 1 677 ? 94.014  120.467 109.829 1.00 43.91  ? 677 GLN A CA    1 
ATOM 4822 C C     . GLN A 1 677 ? 93.059  119.428 110.408 1.00 41.54  ? 677 GLN A C     1 
ATOM 4823 O O     . GLN A 1 677 ? 92.245  119.743 111.283 1.00 42.13  ? 677 GLN A O     1 
ATOM 4824 C CB    . GLN A 1 677 ? 93.469  121.061 108.529 1.00 45.60  ? 677 GLN A CB    1 
ATOM 4825 C CG    . GLN A 1 677 ? 93.690  120.203 107.289 1.00 46.74  ? 677 GLN A CG    1 
ATOM 4826 C CD    . GLN A 1 677 ? 92.567  119.220 107.042 1.00 45.62  ? 677 GLN A CD    1 
ATOM 4827 O OE1   . GLN A 1 677 ? 91.494  119.329 107.631 1.00 45.11  ? 677 GLN A OE1   1 
ATOM 4828 N NE2   . GLN A 1 677 ? 92.813  118.246 106.175 1.00 39.02  ? 677 GLN A NE2   1 
ATOM 4829 N N     . GLN A 1 678 ? 93.186  118.171 109.982 1.00 41.67  ? 678 GLN A N     1 
ATOM 4830 C CA    . GLN A 1 678 ? 92.294  117.130 110.479 1.00 43.31  ? 678 GLN A CA    1 
ATOM 4831 C C     . GLN A 1 678 ? 92.675  116.699 111.895 1.00 43.85  ? 678 GLN A C     1 
ATOM 4832 O O     . GLN A 1 678 ? 91.793  116.449 112.731 1.00 47.22  ? 678 GLN A O     1 
ATOM 4833 C CB    . GLN A 1 678 ? 92.280  115.957 109.492 1.00 38.18  ? 678 GLN A CB    1 
ATOM 4834 C CG    . GLN A 1 678 ? 92.224  114.565 110.086 1.00 39.16  ? 678 GLN A CG    1 
ATOM 4835 C CD    . GLN A 1 678 ? 92.149  113.490 109.021 1.00 44.71  ? 678 GLN A CD    1 
ATOM 4836 O OE1   . GLN A 1 678 ? 92.061  113.787 107.830 1.00 41.30  ? 678 GLN A OE1   1 
ATOM 4837 N NE2   . GLN A 1 678 ? 92.190  112.231 109.444 1.00 49.67  ? 678 GLN A NE2   1 
ATOM 4838 N N     . VAL A 1 679 ? 93.976  116.654 112.207 1.00 41.99  ? 679 VAL A N     1 
ATOM 4839 C CA    . VAL A 1 679 ? 94.352  116.362 113.589 1.00 38.35  ? 679 VAL A CA    1 
ATOM 4840 C C     . VAL A 1 679 ? 94.099  117.556 114.508 1.00 24.10  ? 679 VAL A C     1 
ATOM 4841 O O     . VAL A 1 679 ? 93.881  117.364 115.709 1.00 19.13  ? 679 VAL A O     1 
ATOM 4842 C CB    . VAL A 1 679 ? 95.808  115.860 113.699 1.00 29.92  ? 679 VAL A CB    1 
ATOM 4843 C CG1   . VAL A 1 679 ? 96.046  114.647 112.815 1.00 24.50  ? 679 VAL A CG1   1 
ATOM 4844 C CG2   . VAL A 1 679 ? 96.807  116.949 113.393 1.00 37.34  ? 679 VAL A CG2   1 
ATOM 4845 N N     . LEU A 1 680 ? 94.077  118.780 113.970 1.00 36.36  ? 680 LEU A N     1 
ATOM 4846 C CA    . LEU A 1 680 ? 93.600  119.932 114.729 1.00 45.83  ? 680 LEU A CA    1 
ATOM 4847 C C     . LEU A 1 680 ? 92.109  119.811 115.011 1.00 46.83  ? 680 LEU A C     1 
ATOM 4848 O O     . LEU A 1 680 ? 91.644  120.126 116.113 1.00 58.43  ? 680 LEU A O     1 
ATOM 4849 C CB    . LEU A 1 680 ? 93.898  121.220 113.955 1.00 46.14  ? 680 LEU A CB    1 
ATOM 4850 C CG    . LEU A 1 680 ? 94.305  122.460 114.747 1.00 43.52  ? 680 LEU A CG    1 
ATOM 4851 C CD1   . LEU A 1 680 ? 95.721  122.299 115.212 1.00 40.16  ? 680 LEU A CD1   1 
ATOM 4852 C CD2   . LEU A 1 680 ? 94.173  123.709 113.907 1.00 40.73  ? 680 LEU A CD2   1 
ATOM 4853 N N     . HIS A 1 681 ? 91.347  119.356 114.012 1.00 39.97  ? 681 HIS A N     1 
ATOM 4854 C CA    . HIS A 1 681 ? 89.905  119.188 114.138 1.00 46.80  ? 681 HIS A CA    1 
ATOM 4855 C C     . HIS A 1 681 ? 89.543  118.114 115.155 1.00 46.77  ? 681 HIS A C     1 
ATOM 4856 O O     . HIS A 1 681 ? 88.574  118.287 115.901 1.00 49.12  ? 681 HIS A O     1 
ATOM 4857 C CB    . HIS A 1 681 ? 89.322  118.842 112.759 1.00 52.95  ? 681 HIS A CB    1 
ATOM 4858 C CG    . HIS A 1 681 ? 87.827  118.945 112.657 1.00 54.91  ? 681 HIS A CG    1 
ATOM 4859 N ND1   . HIS A 1 681 ? 87.007  119.238 113.726 1.00 56.97  ? 681 HIS A ND1   1 
ATOM 4860 C CD2   . HIS A 1 681 ? 87.006  118.783 111.592 1.00 50.72  ? 681 HIS A CD2   1 
ATOM 4861 C CE1   . HIS A 1 681 ? 85.749  119.252 113.325 1.00 53.25  ? 681 HIS A CE1   1 
ATOM 4862 N NE2   . HIS A 1 681 ? 85.721  118.980 112.034 1.00 54.17  ? 681 HIS A NE2   1 
ATOM 4863 N N     . HIS A 1 682 ? 90.289  117.013 115.204 1.00 43.38  ? 682 HIS A N     1 
ATOM 4864 C CA    . HIS A 1 682 ? 89.887  115.912 116.068 1.00 45.13  ? 682 HIS A CA    1 
ATOM 4865 C C     . HIS A 1 682 ? 90.685  115.797 117.361 1.00 45.08  ? 682 HIS A C     1 
ATOM 4866 O O     . HIS A 1 682 ? 90.334  114.961 118.200 1.00 48.05  ? 682 HIS A O     1 
ATOM 4867 C CB    . HIS A 1 682 ? 89.980  114.579 115.322 1.00 51.77  ? 682 HIS A CB    1 
ATOM 4868 C CG    . HIS A 1 682 ? 88.959  114.411 114.239 1.00 54.03  ? 682 HIS A CG    1 
ATOM 4869 N ND1   . HIS A 1 682 ? 88.071  113.357 114.214 1.00 51.37  ? 682 HIS A ND1   1 
ATOM 4870 C CD2   . HIS A 1 682 ? 88.694  115.150 113.135 1.00 50.29  ? 682 HIS A CD2   1 
ATOM 4871 C CE1   . HIS A 1 682 ? 87.299  113.458 113.147 1.00 50.53  ? 682 HIS A CE1   1 
ATOM 4872 N NE2   . HIS A 1 682 ? 87.656  114.538 112.476 1.00 48.35  ? 682 HIS A NE2   1 
ATOM 4873 N N     . GLU A 1 683 ? 91.736  116.593 117.562 1.00 47.36  ? 683 GLU A N     1 
ATOM 4874 C CA    . GLU A 1 683 ? 92.520  116.488 118.785 1.00 47.99  ? 683 GLU A CA    1 
ATOM 4875 C C     . GLU A 1 683 ? 92.486  117.742 119.645 1.00 35.00  ? 683 GLU A C     1 
ATOM 4876 O O     . GLU A 1 683 ? 93.174  117.791 120.668 1.00 19.33  ? 683 GLU A O     1 
ATOM 4877 C CB    . GLU A 1 683 ? 93.968  116.121 118.457 1.00 46.44  ? 683 GLU A CB    1 
ATOM 4878 C CG    . GLU A 1 683 ? 94.096  114.772 117.792 1.00 42.57  ? 683 GLU A CG    1 
ATOM 4879 C CD    . GLU A 1 683 ? 95.420  114.123 118.061 1.00 38.86  ? 683 GLU A CD    1 
ATOM 4880 O OE1   . GLU A 1 683 ? 96.071  114.493 119.055 1.00 36.52  ? 683 GLU A OE1   1 
ATOM 4881 O OE2   . GLU A 1 683 ? 95.818  113.256 117.265 1.00 32.32  ? 683 GLU A OE2   1 
ATOM 4882 N N     . LEU A 1 684 ? 91.718  118.753 119.257 1.00 44.52  ? 684 LEU A N     1 
ATOM 4883 C CA    . LEU A 1 684 ? 91.454  119.895 120.118 1.00 48.33  ? 684 LEU A CA    1 
ATOM 4884 C C     . LEU A 1 684 ? 89.978  120.140 120.370 1.00 52.38  ? 684 LEU A C     1 
ATOM 4885 O O     . LEU A 1 684 ? 89.632  120.714 121.404 1.00 58.32  ? 684 LEU A O     1 
ATOM 4886 C CB    . LEU A 1 684 ? 92.069  121.175 119.542 1.00 44.27  ? 684 LEU A CB    1 
ATOM 4887 C CG    . LEU A 1 684 ? 93.546  121.118 119.190 1.00 39.83  ? 684 LEU A CG    1 
ATOM 4888 C CD1   . LEU A 1 684 ? 93.904  122.382 118.473 1.00 45.51  ? 684 LEU A CD1   1 
ATOM 4889 C CD2   . LEU A 1 684 ? 94.383  120.955 120.440 1.00 48.85  ? 684 LEU A CD2   1 
ATOM 4890 N N     . LEU A 1 685 ? 89.096  119.745 119.453 1.00 50.85  ? 685 LEU A N     1 
ATOM 4891 C CA    . LEU A 1 685 ? 87.675  119.784 119.769 1.00 55.75  ? 685 LEU A CA    1 
ATOM 4892 C C     . LEU A 1 685 ? 87.315  118.657 120.725 1.00 60.14  ? 685 LEU A C     1 
ATOM 4893 O O     . LEU A 1 685 ? 86.395  118.792 121.543 1.00 63.78  ? 685 LEU A O     1 
ATOM 4894 C CB    . LEU A 1 685 ? 86.844  119.706 118.488 1.00 59.25  ? 685 LEU A CB    1 
ATOM 4895 C CG    . LEU A 1 685 ? 86.878  120.912 117.541 1.00 59.39  ? 685 LEU A CG    1 
ATOM 4896 C CD1   . LEU A 1 685 ? 85.748  120.823 116.532 1.00 63.18  ? 685 LEU A CD1   1 
ATOM 4897 C CD2   . LEU A 1 685 ? 86.797  122.232 118.297 1.00 55.90  ? 685 LEU A CD2   1 
ATOM 4898 N N     . ALA A 1 686 ? 88.052  117.547 120.652 1.00 65.77  ? 686 ALA A N     1 
ATOM 4899 C CA    . ALA A 1 686 ? 87.796  116.419 121.540 1.00 64.97  ? 686 ALA A CA    1 
ATOM 4900 C C     . ALA A 1 686 ? 88.228  116.729 122.969 1.00 65.78  ? 686 ALA A C     1 
ATOM 4901 O O     . ALA A 1 686 ? 87.534  116.371 123.927 1.00 69.96  ? 686 ALA A O     1 
ATOM 4902 C CB    . ALA A 1 686 ? 88.498  115.171 121.011 1.00 60.94  ? 686 ALA A CB    1 
ATOM 4903 N N     . ILE A 1 687 ? 89.353  117.433 123.137 1.00 54.13  ? 687 ILE A N     1 
ATOM 4904 C CA    . ILE A 1 687 ? 89.774  117.812 124.485 1.00 57.15  ? 687 ILE A CA    1 
ATOM 4905 C C     . ILE A 1 687 ? 88.876  118.922 125.033 1.00 56.52  ? 687 ILE A C     1 
ATOM 4906 O O     . ILE A 1 687 ? 88.667  119.023 126.245 1.00 56.50  ? 687 ILE A O     1 
ATOM 4907 C CB    . ILE A 1 687 ? 91.272  118.192 124.507 1.00 53.71  ? 687 ILE A CB    1 
ATOM 4908 C CG1   . ILE A 1 687 ? 91.805  118.247 125.936 1.00 53.69  ? 687 ILE A CG1   1 
ATOM 4909 C CG2   . ILE A 1 687 ? 91.548  119.525 123.837 1.00 55.73  ? 687 ILE A CG2   1 
ATOM 4910 C CD1   . ILE A 1 687 ? 93.261  118.572 126.011 1.00 51.64  ? 687 ILE A CD1   1 
ATOM 4911 N N     . ARG A 1 688 ? 88.259  119.716 124.149 1.00 56.61  ? 688 ARG A N     1 
ATOM 4912 C CA    . ARG A 1 688 ? 87.345  120.758 124.607 1.00 61.33  ? 688 ARG A CA    1 
ATOM 4913 C C     . ARG A 1 688 ? 86.021  120.160 125.072 1.00 63.62  ? 688 ARG A C     1 
ATOM 4914 O O     . ARG A 1 688 ? 85.491  120.531 126.130 1.00 65.09  ? 688 ARG A O     1 
ATOM 4915 C CB    . ARG A 1 688 ? 87.120  121.779 123.495 1.00 57.25  ? 688 ARG A CB    1 
ATOM 4916 C CG    . ARG A 1 688 ? 86.948  123.195 124.000 1.00 61.65  ? 688 ARG A CG    1 
ATOM 4917 C CD    . ARG A 1 688 ? 87.184  124.206 122.895 1.00 58.50  ? 688 ARG A CD    1 
ATOM 4918 N NE    . ARG A 1 688 ? 88.602  124.491 122.716 1.00 56.91  ? 688 ARG A NE    1 
ATOM 4919 C CZ    . ARG A 1 688 ? 89.355  123.959 121.764 1.00 60.48  ? 688 ARG A CZ    1 
ATOM 4920 N NH1   . ARG A 1 688 ? 88.852  123.117 120.878 1.00 60.99  ? 688 ARG A NH1   1 
ATOM 4921 N NH2   . ARG A 1 688 ? 90.642  124.286 121.695 1.00 63.00  ? 688 ARG A NH2   1 
ATOM 4922 N N     . GLU A 1 689 ? 85.490  119.194 124.310 1.00 66.27  ? 689 GLU A N     1 
ATOM 4923 C CA    . GLU A 1 689 ? 84.278  118.515 124.752 1.00 62.96  ? 689 GLU A CA    1 
ATOM 4924 C C     . GLU A 1 689 ? 84.554  117.541 125.891 1.00 60.35  ? 689 GLU A C     1 
ATOM 4925 O O     . GLU A 1 689 ? 83.612  117.112 126.565 1.00 62.89  ? 689 GLU A O     1 
ATOM 4926 C CB    . GLU A 1 689 ? 83.597  117.785 123.592 1.00 63.09  ? 689 GLU A CB    1 
ATOM 4927 C CG    . GLU A 1 689 ? 84.362  116.609 123.030 1.00 62.62  ? 689 GLU A CG    1 
ATOM 4928 C CD    . GLU A 1 689 ? 83.783  116.123 121.718 1.00 67.77  ? 689 GLU A CD    1 
ATOM 4929 O OE1   . GLU A 1 689 ? 82.549  115.945 121.645 1.00 64.89  ? 689 GLU A OE1   1 
ATOM 4930 O OE2   . GLU A 1 689 ? 84.557  115.927 120.758 1.00 67.40  ? 689 GLU A OE2   1 
ATOM 4931 N N     . ALA A 1 690 ? 85.817  117.180 126.116 1.00 60.31  ? 690 ALA A N     1 
ATOM 4932 C CA    . ALA A 1 690 ? 86.162  116.461 127.332 1.00 66.61  ? 690 ALA A CA    1 
ATOM 4933 C C     . ALA A 1 690 ? 86.244  117.399 128.529 1.00 68.87  ? 690 ALA A C     1 
ATOM 4934 O O     . ALA A 1 690 ? 85.807  117.045 129.630 1.00 71.38  ? 690 ALA A O     1 
ATOM 4935 C CB    . ALA A 1 690 ? 87.482  115.726 127.141 1.00 61.66  ? 690 ALA A CB    1 
ATOM 4936 N N     . CYS A 1 691 ? 86.797  118.599 128.334 1.00 65.23  ? 691 CYS A N     1 
ATOM 4937 C CA    . CYS A 1 691 ? 86.983  119.526 129.444 1.00 65.16  ? 691 CYS A CA    1 
ATOM 4938 C C     . CYS A 1 691 ? 85.669  120.153 129.881 1.00 68.80  ? 691 CYS A C     1 
ATOM 4939 O O     . CYS A 1 691 ? 85.548  120.599 131.028 1.00 72.49  ? 691 CYS A O     1 
ATOM 4940 C CB    . CYS A 1 691 ? 87.995  120.603 129.064 1.00 70.57  ? 691 CYS A CB    1 
ATOM 4941 S SG    . CYS A 1 691 ? 89.711  120.116 129.351 1.00 78.89  ? 691 CYS A SG    1 
ATOM 4942 N N     . ILE A 1 692 ? 84.672  120.196 128.994 1.00 73.52  ? 692 ILE A N     1 
ATOM 4943 C CA    . ILE A 1 692 ? 83.334  120.543 129.470 1.00 75.88  ? 692 ILE A CA    1 
ATOM 4944 C C     . ILE A 1 692 ? 82.650  119.358 130.143 1.00 73.13  ? 692 ILE A C     1 
ATOM 4945 O O     . ILE A 1 692 ? 81.615  119.541 130.794 1.00 71.91  ? 692 ILE A O     1 
ATOM 4946 C CB    . ILE A 1 692 ? 82.428  121.082 128.350 1.00 77.70  ? 692 ILE A CB    1 
ATOM 4947 C CG1   . ILE A 1 692 ? 82.083  119.976 127.354 1.00 73.25  ? 692 ILE A CG1   1 
ATOM 4948 C CG2   . ILE A 1 692 ? 83.075  122.280 127.666 1.00 73.20  ? 692 ILE A CG2   1 
ATOM 4949 C CD1   . ILE A 1 692 ? 81.141  120.410 126.256 1.00 74.16  ? 692 ILE A CD1   1 
ATOM 4950 N N     . LYS A 1 693 ? 83.196  118.149 130.008 1.00 69.41  ? 693 LYS A N     1 
ATOM 4951 C CA    . LYS A 1 693 ? 82.641  116.963 130.649 1.00 70.12  ? 693 LYS A CA    1 
ATOM 4952 C C     . LYS A 1 693 ? 83.324  116.622 131.968 1.00 69.27  ? 693 LYS A C     1 
ATOM 4953 O O     . LYS A 1 693 ? 82.750  115.879 132.771 1.00 75.19  ? 693 LYS A O     1 
ATOM 4954 C CB    . LYS A 1 693 ? 82.729  115.762 129.701 1.00 70.69  ? 693 LYS A CB    1 
ATOM 4955 C CG    . LYS A 1 693 ? 81.409  115.388 129.049 1.00 73.87  ? 693 LYS A CG    1 
ATOM 4956 C CD    . LYS A 1 693 ? 81.513  114.067 128.304 1.00 71.21  ? 693 LYS A CD    1 
ATOM 4957 C CE    . LYS A 1 693 ? 80.178  113.674 127.696 1.00 72.13  ? 693 LYS A CE    1 
ATOM 4958 N NZ    . LYS A 1 693 ? 80.267  112.407 126.921 1.00 73.34  ? 693 LYS A NZ    1 
ATOM 4959 N N     . LEU A 1 694 ? 84.526  117.143 132.216 1.00 54.94  ? 694 LEU A N     1 
ATOM 4960 C CA    . LEU A 1 694 ? 85.220  116.916 133.480 1.00 57.22  ? 694 LEU A CA    1 
ATOM 4961 C C     . LEU A 1 694 ? 84.652  117.781 134.599 1.00 59.86  ? 694 LEU A C     1 
ATOM 4962 O O     . LEU A 1 694 ? 84.104  117.261 135.576 1.00 63.95  ? 694 LEU A O     1 
ATOM 4963 C CB    . LEU A 1 694 ? 86.724  117.180 133.328 1.00 60.32  ? 694 LEU A CB    1 
ATOM 4964 C CG    . LEU A 1 694 ? 87.563  116.166 132.557 1.00 58.76  ? 694 LEU A CG    1 
ATOM 4965 C CD1   . LEU A 1 694 ? 88.468  116.826 131.544 1.00 56.18  ? 694 LEU A CD1   1 
ATOM 4966 C CD2   . LEU A 1 694 ? 88.389  115.406 133.550 1.00 59.92  ? 694 LEU A CD2   1 
ATOM 4967 N N     . GLU A 1 695 ? 84.771  119.099 134.470 1.00 54.60  ? 695 GLU A N     1 
ATOM 4968 C CA    . GLU A 1 695 ? 84.234  120.017 135.462 1.00 55.01  ? 695 GLU A CA    1 
ATOM 4969 C C     . GLU A 1 695 ? 83.838  121.303 134.755 1.00 59.71  ? 695 GLU A C     1 
ATOM 4970 O O     . GLU A 1 695 ? 84.503  121.724 133.806 1.00 58.72  ? 695 GLU A O     1 
ATOM 4971 C CB    . GLU A 1 695 ? 85.249  120.293 136.577 1.00 56.59  ? 695 GLU A CB    1 
ATOM 4972 C CG    . GLU A 1 695 ? 86.673  120.446 136.092 1.00 58.70  ? 695 GLU A CG    1 
ATOM 4973 C CD    . GLU A 1 695 ? 87.589  119.352 136.596 1.00 58.13  ? 695 GLU A CD    1 
ATOM 4974 O OE1   . GLU A 1 695 ? 87.210  118.168 136.504 1.00 55.97  ? 695 GLU A OE1   1 
ATOM 4975 O OE2   . GLU A 1 695 ? 88.691  119.677 137.085 1.00 65.86  ? 695 GLU A OE2   1 
ATOM 4976 N N     . LYS A 1 696 ? 82.745  121.905 135.216 1.00 75.09  ? 696 LYS A N     1 
ATOM 4977 C CA    . LYS A 1 696 ? 82.191  123.080 134.558 1.00 76.36  ? 696 LYS A CA    1 
ATOM 4978 C C     . LYS A 1 696 ? 83.068  124.302 134.808 1.00 73.36  ? 696 LYS A C     1 
ATOM 4979 O O     . LYS A 1 696 ? 83.714  124.421 135.855 1.00 77.33  ? 696 LYS A O     1 
ATOM 4980 C CB    . LYS A 1 696 ? 80.765  123.336 135.052 1.00 75.92  ? 696 LYS A CB    1 
ATOM 4981 C CG    . LYS A 1 696 ? 79.884  124.116 134.083 1.00 75.23  ? 696 LYS A CG    1 
ATOM 4982 C CD    . LYS A 1 696 ? 79.843  123.459 132.710 1.00 75.10  ? 696 LYS A CD    1 
ATOM 4983 C CE    . LYS A 1 696 ? 79.011  122.185 132.719 1.00 72.27  ? 696 LYS A CE    1 
ATOM 4984 N NZ    . LYS A 1 696 ? 78.886  121.598 131.356 1.00 71.47  ? 696 LYS A NZ    1 
ATOM 4985 N N     . ASP A 1 697 ? 83.075  125.206 133.814 1.00 71.89  ? 697 ASP A N     1 
ATOM 4986 C CA    . ASP A 1 697 ? 83.879  126.437 133.785 1.00 74.15  ? 697 ASP A CA    1 
ATOM 4987 C C     . ASP A 1 697 ? 85.369  126.139 133.954 1.00 75.85  ? 697 ASP A C     1 
ATOM 4988 O O     . ASP A 1 697 ? 86.076  126.789 134.725 1.00 72.92  ? 697 ASP A O     1 
ATOM 4989 C CB    . ASP A 1 697 ? 83.396  127.456 134.823 1.00 73.88  ? 697 ASP A CB    1 
ATOM 4990 C CG    . ASP A 1 697 ? 83.545  128.887 134.348 1.00 77.93  ? 697 ASP A CG    1 
ATOM 4991 O OD1   . ASP A 1 697 ? 84.685  129.301 134.052 1.00 80.21  ? 697 ASP A OD1   1 
ATOM 4992 O OD2   . ASP A 1 697 ? 82.521  129.599 134.269 1.00 78.63  ? 697 ASP A OD2   1 
ATOM 4993 N N     . TYR A 1 698 ? 85.843  125.133 133.220 1.00 62.66  ? 698 TYR A N     1 
ATOM 4994 C CA    . TYR A 1 698 ? 87.245  124.721 133.271 1.00 59.78  ? 698 TYR A CA    1 
ATOM 4995 C C     . TYR A 1 698 ? 87.690  124.436 131.841 1.00 57.85  ? 698 TYR A C     1 
ATOM 4996 O O     . TYR A 1 698 ? 87.402  123.369 131.293 1.00 57.32  ? 698 TYR A O     1 
ATOM 4997 C CB    . TYR A 1 698 ? 87.429  123.505 134.168 1.00 57.40  ? 698 TYR A CB    1 
ATOM 4998 C CG    . TYR A 1 698 ? 88.787  122.847 134.070 1.00 51.96  ? 698 TYR A CG    1 
ATOM 4999 C CD1   . TYR A 1 698 ? 89.918  123.469 134.577 1.00 53.95  ? 698 TYR A CD1   1 
ATOM 5000 C CD2   . TYR A 1 698 ? 88.933  121.598 133.480 1.00 50.66  ? 698 TYR A CD2   1 
ATOM 5001 C CE1   . TYR A 1 698 ? 91.156  122.868 134.492 1.00 53.97  ? 698 TYR A CE1   1 
ATOM 5002 C CE2   . TYR A 1 698 ? 90.168  120.993 133.391 1.00 52.26  ? 698 TYR A CE2   1 
ATOM 5003 C CZ    . TYR A 1 698 ? 91.272  121.631 133.902 1.00 49.94  ? 698 TYR A CZ    1 
ATOM 5004 O OH    . TYR A 1 698 ? 92.497  121.028 133.807 1.00 46.30  ? 698 TYR A OH    1 
ATOM 5005 N N     . GLN A 1 699 ? 88.361  125.409 131.231 1.00 63.85  ? 699 GLN A N     1 
ATOM 5006 C CA    . GLN A 1 699 ? 88.955  125.253 129.904 1.00 61.20  ? 699 GLN A CA    1 
ATOM 5007 C C     . GLN A 1 699 ? 90.367  125.814 129.953 1.00 61.13  ? 699 GLN A C     1 
ATOM 5008 O O     . GLN A 1 699 ? 90.591  126.998 129.671 1.00 59.33  ? 699 GLN A O     1 
ATOM 5009 C CB    . GLN A 1 699 ? 88.113  125.949 128.833 1.00 64.03  ? 699 GLN A CB    1 
ATOM 5010 C CG    . GLN A 1 699 ? 86.899  125.151 128.388 1.00 63.43  ? 699 GLN A CG    1 
ATOM 5011 C CD    . GLN A 1 699 ? 85.621  125.626 129.049 1.00 67.82  ? 699 GLN A CD    1 
ATOM 5012 O OE1   . GLN A 1 699 ? 85.324  126.820 129.060 1.00 68.14  ? 699 GLN A OE1   1 
ATOM 5013 N NE2   . GLN A 1 699 ? 84.858  124.692 129.605 1.00 62.35  ? 699 GLN A NE2   1 
ATOM 5014 N N     . PRO A 1 700 ? 91.346  124.997 130.348 1.00 53.68  ? 700 PRO A N     1 
ATOM 5015 C CA    . PRO A 1 700 ? 92.731  125.480 130.417 1.00 52.14  ? 700 PRO A CA    1 
ATOM 5016 C C     . PRO A 1 700 ? 93.315  125.742 129.036 1.00 54.92  ? 700 PRO A C     1 
ATOM 5017 O O     . PRO A 1 700 ? 92.898  125.151 128.038 1.00 55.39  ? 700 PRO A O     1 
ATOM 5018 C CB    . PRO A 1 700 ? 93.473  124.344 131.132 1.00 49.67  ? 700 PRO A CB    1 
ATOM 5019 C CG    . PRO A 1 700 ? 92.608  123.175 131.044 1.00 54.86  ? 700 PRO A CG    1 
ATOM 5020 C CD    . PRO A 1 700 ? 91.206  123.620 130.851 1.00 54.69  ? 700 PRO A CD    1 
ATOM 5021 N N     . GLY A 1 701 ? 94.281  126.656 128.992 1.00 60.79  ? 701 GLY A N     1 
ATOM 5022 C CA    . GLY A 1 701 ? 94.838  127.068 127.714 1.00 60.72  ? 701 GLY A CA    1 
ATOM 5023 C C     . GLY A 1 701 ? 95.775  126.017 127.145 1.00 58.97  ? 701 GLY A C     1 
ATOM 5024 O O     . GLY A 1 701 ? 96.674  125.520 127.827 1.00 58.60  ? 701 GLY A O     1 
ATOM 5025 N N     . ILE A 1 702 ? 95.571  125.698 125.870 1.00 47.43  ? 702 ILE A N     1 
ATOM 5026 C CA    . ILE A 1 702 ? 96.297  124.636 125.185 1.00 46.25  ? 702 ILE A CA    1 
ATOM 5027 C C     . ILE A 1 702 ? 97.449  125.254 124.409 1.00 51.59  ? 702 ILE A C     1 
ATOM 5028 O O     . ILE A 1 702 ? 97.246  126.192 123.629 1.00 58.90  ? 702 ILE A O     1 
ATOM 5029 C CB    . ILE A 1 702 ? 95.377  123.838 124.245 1.00 47.85  ? 702 ILE A CB    1 
ATOM 5030 C CG1   . ILE A 1 702 ? 93.979  123.704 124.851 1.00 45.55  ? 702 ILE A CG1   1 
ATOM 5031 C CG2   . ILE A 1 702 ? 95.971  122.471 123.959 1.00 53.38  ? 702 ILE A CG2   1 
ATOM 5032 C CD1   . ILE A 1 702 ? 92.971  123.049 123.933 1.00 42.73  ? 702 ILE A CD1   1 
ATOM 5033 N N     . THR A 1 703 ? 98.655  124.735 124.626 1.00 43.10  ? 703 THR A N     1 
ATOM 5034 C CA    . THR A 1 703 ? 99.813  125.071 123.802 1.00 39.99  ? 703 THR A CA    1 
ATOM 5035 C C     . THR A 1 703 ? 100.143 123.817 123.006 1.00 35.18  ? 703 THR A C     1 
ATOM 5036 O O     . THR A 1 703 ? 100.904 122.957 123.450 1.00 43.33  ? 703 THR A O     1 
ATOM 5037 C CB    . THR A 1 703 ? 101.011 125.534 124.615 1.00 47.01  ? 703 THR A CB    1 
ATOM 5038 O OG1   . THR A 1 703 ? 101.773 124.399 125.020 1.00 53.87  ? 703 THR A OG1   1 
ATOM 5039 C CG2   . THR A 1 703 ? 100.574 126.296 125.845 1.00 49.27  ? 703 THR A CG2   1 
ATOM 5040 N N     . PHE A 1 704 ? 99.551  123.718 121.826 1.00 25.09  ? 704 PHE A N     1 
ATOM 5041 C CA    . PHE A 1 704 ? 99.664  122.527 121.000 1.00 27.26  ? 704 PHE A CA    1 
ATOM 5042 C C     . PHE A 1 704 ? 100.924 122.633 120.154 1.00 18.59  ? 704 PHE A C     1 
ATOM 5043 O O     . PHE A 1 704 ? 101.079 123.568 119.362 1.00 20.44  ? 704 PHE A O     1 
ATOM 5044 C CB    . PHE A 1 704 ? 98.398  122.389 120.158 1.00 24.57  ? 704 PHE A CB    1 
ATOM 5045 C CG    . PHE A 1 704 ? 98.258  121.092 119.414 1.00 19.07  ? 704 PHE A CG    1 
ATOM 5046 C CD1   . PHE A 1 704 ? 98.952  119.953 119.786 1.00 25.59  ? 704 PHE A CD1   1 
ATOM 5047 C CD2   . PHE A 1 704 ? 97.380  121.016 118.349 1.00 25.33  ? 704 PHE A CD2   1 
ATOM 5048 C CE1   . PHE A 1 704 ? 98.795  118.781 119.095 1.00 30.75  ? 704 PHE A CE1   1 
ATOM 5049 C CE2   . PHE A 1 704 ? 97.218  119.848 117.657 1.00 32.76  ? 704 PHE A CE2   1 
ATOM 5050 C CZ    . PHE A 1 704 ? 97.921  118.732 118.036 1.00 36.85  ? 704 PHE A CZ    1 
ATOM 5051 N N     . ILE A 1 705 ? 101.822 121.674 120.340 1.00 9.64   ? 705 ILE A N     1 
ATOM 5052 C CA    . ILE A 1 705 ? 103.100 121.615 119.651 1.00 6.20   ? 705 ILE A CA    1 
ATOM 5053 C C     . ILE A 1 705 ? 103.141 120.312 118.881 1.00 22.07  ? 705 ILE A C     1 
ATOM 5054 O O     . ILE A 1 705 ? 103.097 119.236 119.483 1.00 37.35  ? 705 ILE A O     1 
ATOM 5055 C CB    . ILE A 1 705 ? 104.274 121.691 120.635 1.00 4.66   ? 705 ILE A CB    1 
ATOM 5056 C CG1   . ILE A 1 705 ? 104.178 122.962 121.489 1.00 23.77  ? 705 ILE A CG1   1 
ATOM 5057 C CG2   . ILE A 1 705 ? 105.599 121.513 119.900 1.00 0.28   ? 705 ILE A CG2   1 
ATOM 5058 C CD1   . ILE A 1 705 ? 105.188 123.056 122.591 1.00 17.76  ? 705 ILE A CD1   1 
ATOM 5059 N N     . VAL A 1 706 ? 103.222 120.397 117.560 1.00 33.83  ? 706 VAL A N     1 
ATOM 5060 C CA    . VAL A 1 706 ? 103.343 119.219 116.710 1.00 9.91   ? 706 VAL A CA    1 
ATOM 5061 C C     . VAL A 1 706 ? 104.741 119.188 116.129 1.00 17.68  ? 706 VAL A C     1 
ATOM 5062 O O     . VAL A 1 706 ? 105.142 120.078 115.372 1.00 37.56  ? 706 VAL A O     1 
ATOM 5063 C CB    . VAL A 1 706 ? 102.287 119.184 115.609 1.00 0.00   ? 706 VAL A CB    1 
ATOM 5064 C CG1   . VAL A 1 706 ? 102.335 117.860 114.936 1.00 8.65   ? 706 VAL A CG1   1 
ATOM 5065 C CG2   . VAL A 1 706 ? 100.959 119.320 116.239 1.00 14.69  ? 706 VAL A CG2   1 
ATOM 5066 N N     . VAL A 1 707 ? 105.458 118.153 116.445 1.00 0.00   ? 707 VAL A N     1 
ATOM 5067 C CA    . VAL A 1 707 ? 106.835 118.008 116.029 1.00 0.00   ? 707 VAL A CA    1 
ATOM 5068 C C     . VAL A 1 707 ? 106.842 117.221 114.733 1.00 15.19  ? 707 VAL A C     1 
ATOM 5069 O O     . VAL A 1 707 ? 105.802 116.696 114.314 1.00 22.86  ? 707 VAL A O     1 
ATOM 5070 C CB    . VAL A 1 707 ? 107.636 117.305 117.125 1.00 0.00   ? 707 VAL A CB    1 
ATOM 5071 C CG1   . VAL A 1 707 ? 107.379 117.982 118.446 1.00 8.75   ? 707 VAL A CG1   1 
ATOM 5072 C CG2   . VAL A 1 707 ? 107.238 115.882 117.198 1.00 27.44  ? 707 VAL A CG2   1 
ATOM 5073 N N     . GLN A 1 708 ? 107.987 117.186 114.054 1.00 18.57  ? 708 GLN A N     1 
ATOM 5074 C CA    . GLN A 1 708 ? 108.040 116.459 112.792 1.00 19.95  ? 708 GLN A CA    1 
ATOM 5075 C C     . GLN A 1 708 ? 109.037 115.310 112.818 1.00 24.95  ? 708 GLN A C     1 
ATOM 5076 O O     . GLN A 1 708 ? 108.676 114.174 112.496 1.00 34.41  ? 708 GLN A O     1 
ATOM 5077 C CB    . GLN A 1 708 ? 108.352 117.430 111.650 1.00 26.10  ? 708 GLN A CB    1 
ATOM 5078 C CG    . GLN A 1 708 ? 107.336 118.570 111.485 1.00 23.30  ? 708 GLN A CG    1 
ATOM 5079 C CD    . GLN A 1 708 ? 105.986 118.172 110.896 1.00 19.61  ? 708 GLN A CD    1 
ATOM 5080 O OE1   . GLN A 1 708 ? 105.275 117.309 111.409 1.00 10.43  ? 708 GLN A OE1   1 
ATOM 5081 N NE2   . GLN A 1 708 ? 105.623 118.832 109.811 1.00 32.16  ? 708 GLN A NE2   1 
ATOM 5082 N N     . LYS A 1 709 ? 110.308 115.616 113.091 1.00 16.19  ? 709 LYS A N     1 
ATOM 5083 C CA    . LYS A 1 709 ? 111.431 114.716 113.368 1.00 11.53  ? 709 LYS A CA    1 
ATOM 5084 C C     . LYS A 1 709 ? 111.909 113.946 112.126 1.00 21.93  ? 709 LYS A C     1 
ATOM 5085 O O     . LYS A 1 709 ? 113.032 113.425 112.131 1.00 29.44  ? 709 LYS A O     1 
ATOM 5086 C CB    . LYS A 1 709 ? 111.093 113.742 114.519 1.00 20.81  ? 709 LYS A CB    1 
ATOM 5087 C CG    . LYS A 1 709 ? 112.222 112.962 115.178 1.00 27.28  ? 709 LYS A CG    1 
ATOM 5088 C CD    . LYS A 1 709 ? 113.149 113.876 115.927 1.00 24.59  ? 709 LYS A CD    1 
ATOM 5089 C CE    . LYS A 1 709 ? 113.991 113.095 116.904 1.00 31.04  ? 709 LYS A CE    1 
ATOM 5090 N NZ    . LYS A 1 709 ? 114.132 111.657 116.536 1.00 34.89  ? 709 LYS A NZ    1 
ATOM 5091 N N     . ARG A 1 710 ? 111.159 113.953 111.023 1.00 26.79  ? 710 ARG A N     1 
ATOM 5092 C CA    . ARG A 1 710 ? 111.610 113.340 109.773 1.00 26.61  ? 710 ARG A CA    1 
ATOM 5093 C C     . ARG A 1 710 ? 111.324 114.319 108.633 1.00 34.04  ? 710 ARG A C     1 
ATOM 5094 O O     . ARG A 1 710 ? 110.174 114.581 108.263 1.00 36.33  ? 710 ARG A O     1 
ATOM 5095 C CB    . ARG A 1 710 ? 111.012 111.940 109.565 1.00 30.71  ? 710 ARG A CB    1 
ATOM 5096 C CG    . ARG A 1 710 ? 109.488 111.745 109.471 1.00 34.29  ? 710 ARG A CG    1 
ATOM 5097 C CD    . ARG A 1 710 ? 109.143 110.273 109.291 1.00 37.92  ? 710 ARG A CD    1 
ATOM 5098 N NE    . ARG A 1 710 ? 109.930 109.665 108.223 1.00 32.95  ? 710 ARG A NE    1 
ATOM 5099 C CZ    . ARG A 1 710 ? 109.707 108.462 107.712 1.00 31.69  ? 710 ARG A CZ    1 
ATOM 5100 N NH1   . ARG A 1 710 ? 108.714 107.701 108.142 1.00 36.43  ? 710 ARG A NH1   1 
ATOM 5101 N NH2   . ARG A 1 710 ? 110.500 108.012 106.744 1.00 30.32  ? 710 ARG A NH2   1 
ATOM 5102 N N     . HIS A 1 711 ? 112.396 114.916 108.130 1.00 27.47  ? 711 HIS A N     1 
ATOM 5103 C CA    . HIS A 1 711 ? 112.343 115.923 107.080 1.00 27.33  ? 711 HIS A CA    1 
ATOM 5104 C C     . HIS A 1 711 ? 113.723 115.978 106.445 1.00 29.99  ? 711 HIS A C     1 
ATOM 5105 O O     . HIS A 1 711 ? 114.703 115.471 106.996 1.00 27.16  ? 711 HIS A O     1 
ATOM 5106 C CB    . HIS A 1 711 ? 111.925 117.296 107.615 1.00 21.58  ? 711 HIS A CB    1 
ATOM 5107 C CG    . HIS A 1 711 ? 112.595 117.674 108.897 1.00 20.78  ? 711 HIS A CG    1 
ATOM 5108 N ND1   . HIS A 1 711 ? 111.896 117.910 110.058 1.00 24.69  ? 711 HIS A ND1   1 
ATOM 5109 C CD2   . HIS A 1 711 ? 113.902 117.832 109.208 1.00 29.89  ? 711 HIS A CD2   1 
ATOM 5110 C CE1   . HIS A 1 711 ? 112.742 118.207 111.027 1.00 35.33  ? 711 HIS A CE1   1 
ATOM 5111 N NE2   . HIS A 1 711 ? 113.966 118.168 110.537 1.00 26.73  ? 711 HIS A NE2   1 
ATOM 5112 N N     . HIS A 1 712 ? 113.787 116.609 105.276 1.00 41.02  ? 712 HIS A N     1 
ATOM 5113 C CA    . HIS A 1 712 ? 115.023 116.732 104.521 1.00 38.57  ? 712 HIS A CA    1 
ATOM 5114 C C     . HIS A 1 712 ? 115.656 118.105 104.685 1.00 35.73  ? 712 HIS A C     1 
ATOM 5115 O O     . HIS A 1 712 ? 116.391 118.560 103.803 1.00 34.95  ? 712 HIS A O     1 
ATOM 5116 C CB    . HIS A 1 712 ? 114.758 116.435 103.048 1.00 34.01  ? 712 HIS A CB    1 
ATOM 5117 C CG    . HIS A 1 712 ? 113.967 115.186 102.828 1.00 36.33  ? 712 HIS A CG    1 
ATOM 5118 N ND1   . HIS A 1 712 ? 112.686 115.198 102.324 1.00 40.46  ? 712 HIS A ND1   1 
ATOM 5119 C CD2   . HIS A 1 712 ? 114.273 113.887 103.051 1.00 34.20  ? 712 HIS A CD2   1 
ATOM 5120 C CE1   . HIS A 1 712 ? 112.236 113.959 102.244 1.00 34.18  ? 712 HIS A CE1   1 
ATOM 5121 N NE2   . HIS A 1 712 ? 113.180 113.144 102.677 1.00 35.74  ? 712 HIS A NE2   1 
ATOM 5122 N N     . THR A 1 713 ? 115.377 118.782 105.792 1.00 33.92  ? 713 THR A N     1 
ATOM 5123 C CA    . THR A 1 713 ? 115.866 120.131 106.031 1.00 33.90  ? 713 THR A CA    1 
ATOM 5124 C C     . THR A 1 713 ? 116.841 120.115 107.195 1.00 24.85  ? 713 THR A C     1 
ATOM 5125 O O     . THR A 1 713 ? 116.493 119.662 108.286 1.00 24.76  ? 713 THR A O     1 
ATOM 5126 C CB    . THR A 1 713 ? 114.724 121.085 106.341 1.00 34.66  ? 713 THR A CB    1 
ATOM 5127 O OG1   . THR A 1 713 ? 113.717 120.983 105.327 1.00 40.99  ? 713 THR A OG1   1 
ATOM 5128 C CG2   . THR A 1 713 ? 115.278 122.463 106.357 1.00 39.46  ? 713 THR A CG2   1 
ATOM 5129 N N     . ARG A 1 714 ? 118.050 120.615 106.967 1.00 36.59  ? 714 ARG A N     1 
ATOM 5130 C CA    . ARG A 1 714 ? 119.131 120.563 107.937 1.00 40.79  ? 714 ARG A CA    1 
ATOM 5131 C C     . ARG A 1 714 ? 119.661 121.968 108.209 1.00 49.90  ? 714 ARG A C     1 
ATOM 5132 O O     . ARG A 1 714 ? 119.250 122.948 107.580 1.00 48.60  ? 714 ARG A O     1 
ATOM 5133 C CB    . ARG A 1 714 ? 120.260 119.650 107.439 1.00 36.92  ? 714 ARG A CB    1 
ATOM 5134 C CG    . ARG A 1 714 ? 119.794 118.272 106.998 1.00 33.03  ? 714 ARG A CG    1 
ATOM 5135 C CD    . ARG A 1 714 ? 119.043 117.570 108.108 1.00 33.42  ? 714 ARG A CD    1 
ATOM 5136 N NE    . ARG A 1 714 ? 118.073 116.606 107.608 1.00 45.85  ? 714 ARG A NE    1 
ATOM 5137 C CZ    . ARG A 1 714 ? 117.972 115.356 108.037 1.00 38.18  ? 714 ARG A CZ    1 
ATOM 5138 N NH1   . ARG A 1 714 ? 118.815 114.861 108.926 1.00 41.97  ? 714 ARG A NH1   1 
ATOM 5139 N NH2   . ARG A 1 714 ? 117.003 114.582 107.557 1.00 35.48  ? 714 ARG A NH2   1 
ATOM 5140 N N     . LEU A 1 715 ? 120.562 122.062 109.191 1.00 47.41  ? 715 LEU A N     1 
ATOM 5141 C CA    . LEU A 1 715 ? 121.287 123.289 109.508 1.00 44.94  ? 715 LEU A CA    1 
ATOM 5142 C C     . LEU A 1 715 ? 122.750 122.943 109.736 1.00 53.23  ? 715 LEU A C     1 
ATOM 5143 O O     . LEU A 1 715 ? 123.053 121.945 110.398 1.00 51.53  ? 715 LEU A O     1 
ATOM 5144 C CB    . LEU A 1 715 ? 120.733 123.977 110.753 1.00 41.50  ? 715 LEU A CB    1 
ATOM 5145 C CG    . LEU A 1 715 ? 119.241 124.237 110.872 1.00 48.67  ? 715 LEU A CG    1 
ATOM 5146 C CD1   . LEU A 1 715 ? 118.880 124.613 112.301 1.00 53.45  ? 715 LEU A CD1   1 
ATOM 5147 C CD2   . LEU A 1 715 ? 118.908 125.336 109.930 1.00 44.61  ? 715 LEU A CD2   1 
ATOM 5148 N N     . PHE A 1 716 ? 123.650 123.777 109.214 1.00 48.21  ? 716 PHE A N     1 
ATOM 5149 C CA    . PHE A 1 716 ? 125.085 123.527 109.272 1.00 45.22  ? 716 PHE A CA    1 
ATOM 5150 C C     . PHE A 1 716 ? 125.811 124.709 109.893 1.00 43.37  ? 716 PHE A C     1 
ATOM 5151 O O     . PHE A 1 716 ? 125.437 125.864 109.675 1.00 42.07  ? 716 PHE A O     1 
ATOM 5152 C CB    . PHE A 1 716 ? 125.645 123.241 107.879 1.00 44.65  ? 716 PHE A CB    1 
ATOM 5153 C CG    . PHE A 1 716 ? 125.053 122.025 107.237 1.00 43.87  ? 716 PHE A CG    1 
ATOM 5154 C CD1   . PHE A 1 716 ? 125.395 120.763 107.687 1.00 39.52  ? 716 PHE A CD1   1 
ATOM 5155 C CD2   . PHE A 1 716 ? 124.128 122.146 106.213 1.00 46.38  ? 716 PHE A CD2   1 
ATOM 5156 C CE1   . PHE A 1 716 ? 124.851 119.648 107.110 1.00 42.89  ? 716 PHE A CE1   1 
ATOM 5157 C CE2   . PHE A 1 716 ? 123.575 121.030 105.637 1.00 46.31  ? 716 PHE A CE2   1 
ATOM 5158 C CZ    . PHE A 1 716 ? 123.935 119.781 106.084 1.00 45.61  ? 716 PHE A CZ    1 
ATOM 5159 N N     . CYS A 1 717 ? 126.863 124.400 110.650 1.00 51.28  ? 717 CYS A N     1 
ATOM 5160 C CA    . CYS A 1 717 ? 127.554 125.396 111.457 1.00 53.37  ? 717 CYS A CA    1 
ATOM 5161 C C     . CYS A 1 717 ? 128.335 126.357 110.570 1.00 58.82  ? 717 CYS A C     1 
ATOM 5162 O O     . CYS A 1 717 ? 128.835 125.975 109.508 1.00 58.68  ? 717 CYS A O     1 
ATOM 5163 C CB    . CYS A 1 717 ? 128.485 124.700 112.451 1.00 56.72  ? 717 CYS A CB    1 
ATOM 5164 S SG    . CYS A 1 717 ? 128.789 125.611 113.984 1.00 68.94  ? 717 CYS A SG    1 
ATOM 5165 N N     . THR A 1 718 ? 128.432 127.610 111.012 1.00 60.48  ? 718 THR A N     1 
ATOM 5166 C CA    . THR A 1 718 ? 128.965 128.694 110.190 1.00 58.44  ? 718 THR A CA    1 
ATOM 5167 C C     . THR A 1 718 ? 130.478 128.590 110.128 1.00 60.32  ? 718 THR A C     1 
ATOM 5168 O O     . THR A 1 718 ? 131.175 129.094 111.013 1.00 59.62  ? 718 THR A O     1 
ATOM 5169 C CB    . THR A 1 718 ? 128.558 130.044 110.755 1.00 62.15  ? 718 THR A CB    1 
ATOM 5170 O OG1   . THR A 1 718 ? 127.167 130.022 111.079 1.00 57.89  ? 718 THR A OG1   1 
ATOM 5171 C CG2   . THR A 1 718 ? 128.818 131.136 109.728 1.00 61.89  ? 718 THR A CG2   1 
ATOM 5172 N N     . ASP A 1 719 ? 130.972 127.923 109.074 1.00 63.50  ? 719 ASP A N     1 
ATOM 5173 C CA    . ASP A 1 719 ? 132.402 127.747 108.775 1.00 69.58  ? 719 ASP A CA    1 
ATOM 5174 C C     . ASP A 1 719 ? 133.145 127.070 109.927 1.00 70.31  ? 719 ASP A C     1 
ATOM 5175 O O     . ASP A 1 719 ? 134.328 127.330 110.164 1.00 73.56  ? 719 ASP A O     1 
ATOM 5176 C CB    . ASP A 1 719 ? 133.062 129.079 108.391 1.00 72.12  ? 719 ASP A CB    1 
ATOM 5177 C CG    . ASP A 1 719 ? 132.306 129.817 107.288 1.00 72.17  ? 719 ASP A CG    1 
ATOM 5178 O OD1   . ASP A 1 719 ? 131.105 130.110 107.468 1.00 72.44  ? 719 ASP A OD1   1 
ATOM 5179 O OD2   . ASP A 1 719 ? 132.919 130.112 106.240 1.00 70.49  ? 719 ASP A OD2   1 
ATOM 5180 N N     . LYS A 1 720 ? 132.428 126.181 110.620 1.00 67.28  ? 720 LYS A N     1 
ATOM 5181 C CA    . LYS A 1 720 ? 132.857 125.483 111.839 1.00 64.07  ? 720 LYS A CA    1 
ATOM 5182 C C     . LYS A 1 720 ? 133.348 126.458 112.910 1.00 64.20  ? 720 LYS A C     1 
ATOM 5183 O O     . LYS A 1 720 ? 134.460 126.353 113.432 1.00 65.90  ? 720 LYS A O     1 
ATOM 5184 C CB    . LYS A 1 720 ? 133.906 124.410 111.532 1.00 62.23  ? 720 LYS A CB    1 
ATOM 5185 C CG    . LYS A 1 720 ? 133.436 123.277 110.595 1.00 66.51  ? 720 LYS A CG    1 
ATOM 5186 C CD    . LYS A 1 720 ? 131.966 122.863 110.779 1.00 63.79  ? 720 LYS A CD    1 
ATOM 5187 C CE    . LYS A 1 720 ? 131.772 121.931 111.961 1.00 66.11  ? 720 LYS A CE    1 
ATOM 5188 N NZ    . LYS A 1 720 ? 131.760 120.503 111.551 1.00 65.68  ? 720 LYS A NZ    1 
ATOM 5189 N N     . ASN A 1 721 ? 132.488 127.428 113.230 1.00 68.68  ? 721 ASN A N     1 
ATOM 5190 C CA    . ASN A 1 721 ? 132.781 128.359 114.314 1.00 72.92  ? 721 ASN A CA    1 
ATOM 5191 C C     . ASN A 1 721 ? 132.667 127.679 115.675 1.00 71.85  ? 721 ASN A C     1 
ATOM 5192 O O     . ASN A 1 721 ? 133.448 127.970 116.588 1.00 74.60  ? 721 ASN A O     1 
ATOM 5193 C CB    . ASN A 1 721 ? 131.837 129.561 114.240 1.00 73.68  ? 721 ASN A CB    1 
ATOM 5194 C CG    . ASN A 1 721 ? 132.563 130.887 114.370 1.00 71.07  ? 721 ASN A CG    1 
ATOM 5195 O OD1   . ASN A 1 721 ? 133.697 131.036 113.916 1.00 70.03  ? 721 ASN A OD1   1 
ATOM 5196 N ND2   . ASN A 1 721 ? 131.908 131.861 114.990 1.00 69.15  ? 721 ASN A ND2   1 
ATOM 5197 N N     . GLU A 1 722 ? 131.705 126.772 115.827 1.00 64.94  ? 722 GLU A N     1 
ATOM 5198 C CA    . GLU A 1 722 ? 131.384 126.134 117.100 1.00 66.33  ? 722 GLU A CA    1 
ATOM 5199 C C     . GLU A 1 722 ? 131.214 124.630 116.919 1.00 70.01  ? 722 GLU A C     1 
ATOM 5200 O O     . GLU A 1 722 ? 130.172 124.056 117.242 1.00 65.59  ? 722 GLU A O     1 
ATOM 5201 C CB    . GLU A 1 722 ? 130.136 126.750 117.725 1.00 69.94  ? 722 GLU A CB    1 
ATOM 5202 C CG    . GLU A 1 722 ? 130.186 126.858 119.244 1.00 70.56  ? 722 GLU A CG    1 
ATOM 5203 C CD    . GLU A 1 722 ? 131.574 127.174 119.767 1.00 69.12  ? 722 GLU A CD    1 
ATOM 5204 O OE1   . GLU A 1 722 ? 132.041 128.315 119.563 1.00 69.03  ? 722 GLU A OE1   1 
ATOM 5205 O OE2   . GLU A 1 722 ? 132.198 126.285 120.383 1.00 68.01  ? 722 GLU A OE2   1 
ATOM 5206 N N     . ARG A 1 723 ? 132.225 123.993 116.326 1.00 78.52  ? 723 ARG A N     1 
ATOM 5207 C CA    . ARG A 1 723 ? 132.240 122.543 116.143 1.00 78.83  ? 723 ARG A CA    1 
ATOM 5208 C C     . ARG A 1 723 ? 132.213 121.800 117.474 1.00 74.20  ? 723 ARG A C     1 
ATOM 5209 O O     . ARG A 1 723 ? 133.091 121.978 118.322 1.00 79.32  ? 723 ARG A O     1 
ATOM 5210 C CB    . ARG A 1 723 ? 133.486 122.143 115.350 1.00 76.90  ? 723 ARG A CB    1 
ATOM 5211 C CG    . ARG A 1 723 ? 133.547 120.675 114.947 1.00 79.79  ? 723 ARG A CG    1 
ATOM 5212 C CD    . ARG A 1 723 ? 134.989 120.195 114.811 1.00 77.04  ? 723 ARG A CD    1 
ATOM 5213 N NE    . ARG A 1 723 ? 135.890 121.254 114.367 1.00 75.36  ? 723 ARG A NE    1 
ATOM 5214 C CZ    . ARG A 1 723 ? 136.146 121.538 113.097 1.00 79.26  ? 723 ARG A CZ    1 
ATOM 5215 N NH1   . ARG A 1 723 ? 135.581 120.864 112.110 1.00 81.10  ? 723 ARG A NH1   1 
ATOM 5216 N NH2   . ARG A 1 723 ? 136.987 122.527 112.811 1.00 78.04  ? 723 ARG A NH2   1 
ATOM 5217 N N     . VAL A 1 724 ? 131.197 120.958 117.643 1.00 55.61  ? 724 VAL A N     1 
ATOM 5218 C CA    . VAL A 1 724 ? 130.985 120.203 118.870 1.00 61.18  ? 724 VAL A CA    1 
ATOM 5219 C C     . VAL A 1 724 ? 130.779 118.735 118.503 1.00 69.57  ? 724 VAL A C     1 
ATOM 5220 O O     . VAL A 1 724 ? 130.040 118.418 117.564 1.00 71.94  ? 724 VAL A O     1 
ATOM 5221 C CB    . VAL A 1 724 ? 129.804 120.776 119.691 1.00 63.93  ? 724 VAL A CB    1 
ATOM 5222 C CG1   . VAL A 1 724 ? 128.546 121.003 118.832 1.00 61.99  ? 724 VAL A CG1   1 
ATOM 5223 C CG2   . VAL A 1 724 ? 129.493 119.914 120.914 1.00 65.39  ? 724 VAL A CG2   1 
ATOM 5224 N N     . GLY A 1 725 ? 131.493 117.847 119.191 1.00 67.89  ? 725 GLY A N     1 
ATOM 5225 C CA    . GLY A 1 725 ? 131.325 116.422 118.988 1.00 54.98  ? 725 GLY A CA    1 
ATOM 5226 C C     . GLY A 1 725 ? 132.031 115.896 117.757 1.00 51.68  ? 725 GLY A C     1 
ATOM 5227 O O     . GLY A 1 725 ? 132.561 116.669 116.953 1.00 49.24  ? 725 GLY A O     1 
ATOM 5228 N N     . LYS A 1 726 ? 132.035 114.571 117.593 1.00 48.25  ? 726 LYS A N     1 
ATOM 5229 C CA    . LYS A 1 726 ? 132.664 113.974 116.421 1.00 46.80  ? 726 LYS A CA    1 
ATOM 5230 C C     . LYS A 1 726 ? 131.767 114.062 115.193 1.00 48.44  ? 726 LYS A C     1 
ATOM 5231 O O     . LYS A 1 726 ? 132.230 113.827 114.072 1.00 47.11  ? 726 LYS A O     1 
ATOM 5232 C CB    . LYS A 1 726 ? 133.030 112.519 116.705 1.00 46.89  ? 726 LYS A CB    1 
ATOM 5233 C CG    . LYS A 1 726 ? 133.547 112.267 118.112 1.00 51.63  ? 726 LYS A CG    1 
ATOM 5234 C CD    . LYS A 1 726 ? 134.106 110.856 118.254 1.00 49.31  ? 726 LYS A CD    1 
ATOM 5235 C CE    . LYS A 1 726 ? 133.028 109.805 118.050 1.00 50.00  ? 726 LYS A CE    1 
ATOM 5236 N NZ    . LYS A 1 726 ? 133.585 108.425 118.072 1.00 47.97  ? 726 LYS A NZ    1 
ATOM 5237 N N     . SER A 1 727 ? 130.486 114.381 115.384 1.00 54.10  ? 727 SER A N     1 
ATOM 5238 C CA    . SER A 1 727 ? 129.581 114.522 114.249 1.00 47.63  ? 727 SER A CA    1 
ATOM 5239 C C     . SER A 1 727 ? 129.799 115.843 113.525 1.00 43.94  ? 727 SER A C     1 
ATOM 5240 O O     . SER A 1 727 ? 129.600 115.932 112.309 1.00 46.71  ? 727 SER A O     1 
ATOM 5241 C CB    . SER A 1 727 ? 128.132 114.407 114.716 1.00 51.03  ? 727 SER A CB    1 
ATOM 5242 O OG    . SER A 1 727 ? 127.563 115.690 114.904 1.00 43.26  ? 727 SER A OG    1 
ATOM 5243 N N     . GLY A 1 728 ? 130.192 116.883 114.251 1.00 41.66  ? 728 GLY A N     1 
ATOM 5244 C CA    . GLY A 1 728 ? 130.340 118.186 113.643 1.00 40.97  ? 728 GLY A CA    1 
ATOM 5245 C C     . GLY A 1 728 ? 129.050 118.946 113.449 1.00 36.40  ? 728 GLY A C     1 
ATOM 5246 O O     . GLY A 1 728 ? 129.045 119.957 112.739 1.00 36.95  ? 728 GLY A O     1 
ATOM 5247 N N     . ASN A 1 729 ? 127.957 118.497 114.061 1.00 37.86  ? 729 ASN A N     1 
ATOM 5248 C CA    . ASN A 1 729 ? 126.683 119.181 113.938 1.00 39.09  ? 729 ASN A CA    1 
ATOM 5249 C C     . ASN A 1 729 ? 126.649 120.429 114.817 1.00 44.67  ? 729 ASN A C     1 
ATOM 5250 O O     . ASN A 1 729 ? 127.555 120.696 115.610 1.00 54.02  ? 729 ASN A O     1 
ATOM 5251 C CB    . ASN A 1 729 ? 125.536 118.253 114.317 1.00 39.50  ? 729 ASN A CB    1 
ATOM 5252 C CG    . ASN A 1 729 ? 124.314 118.479 113.475 1.00 39.09  ? 729 ASN A CG    1 
ATOM 5253 O OD1   . ASN A 1 729 ? 124.349 119.219 112.497 1.00 41.08  ? 729 ASN A OD1   1 
ATOM 5254 N ND2   . ASN A 1 729 ? 123.211 117.878 113.872 1.00 40.09  ? 729 ASN A ND2   1 
ATOM 5255 N N     . ILE A 1 730 ? 125.557 121.178 114.686 1.00 35.46  ? 730 ILE A N     1 
ATOM 5256 C CA    . ILE A 1 730 ? 125.347 122.469 115.339 1.00 37.97  ? 730 ILE A CA    1 
ATOM 5257 C C     . ILE A 1 730 ? 125.167 122.279 116.843 1.00 29.73  ? 730 ILE A C     1 
ATOM 5258 O O     . ILE A 1 730 ? 124.866 121.159 117.282 1.00 28.03  ? 730 ILE A O     1 
ATOM 5259 C CB    . ILE A 1 730 ? 124.142 123.185 114.710 1.00 36.50  ? 730 ILE A CB    1 
ATOM 5260 C CG1   . ILE A 1 730 ? 122.871 122.369 114.931 1.00 36.32  ? 730 ILE A CG1   1 
ATOM 5261 C CG2   . ILE A 1 730 ? 124.409 123.432 113.239 1.00 41.56  ? 730 ILE A CG2   1 
ATOM 5262 C CD1   . ILE A 1 730 ? 121.682 122.836 114.135 1.00 32.74  ? 730 ILE A CD1   1 
ATOM 5263 N N     . PRO A 1 731 ? 125.378 123.309 117.673 1.00 30.23  ? 731 PRO A N     1 
ATOM 5264 C CA    . PRO A 1 731 ? 125.114 123.157 119.110 1.00 38.36  ? 731 PRO A CA    1 
ATOM 5265 C C     . PRO A 1 731 ? 123.632 123.007 119.428 1.00 37.20  ? 731 PRO A C     1 
ATOM 5266 O O     . PRO A 1 731 ? 122.761 123.205 118.580 1.00 34.62  ? 731 PRO A O     1 
ATOM 5267 C CB    . PRO A 1 731 ? 125.686 124.446 119.718 1.00 40.06  ? 731 PRO A CB    1 
ATOM 5268 C CG    . PRO A 1 731 ? 125.851 125.385 118.576 1.00 37.90  ? 731 PRO A CG    1 
ATOM 5269 C CD    . PRO A 1 731 ? 126.174 124.522 117.409 1.00 40.23  ? 731 PRO A CD    1 
ATOM 5270 N N     . ALA A 1 732 ? 123.357 122.627 120.674 1.00 31.65  ? 732 ALA A N     1 
ATOM 5271 C CA    . ALA A 1 732 ? 122.000 122.285 121.070 1.00 17.45  ? 732 ALA A CA    1 
ATOM 5272 C C     . ALA A 1 732 ? 121.152 123.530 121.288 1.00 16.87  ? 732 ALA A C     1 
ATOM 5273 O O     . ALA A 1 732 ? 121.637 124.560 121.757 1.00 32.83  ? 732 ALA A O     1 
ATOM 5274 C CB    . ALA A 1 732 ? 122.018 121.443 122.340 1.00 28.47  ? 732 ALA A CB    1 
ATOM 5275 N N     . GLY A 1 733 ? 119.870 123.418 120.959 1.00 23.25  ? 733 GLY A N     1 
ATOM 5276 C CA    . GLY A 1 733 ? 118.908 124.471 121.187 1.00 25.29  ? 733 GLY A CA    1 
ATOM 5277 C C     . GLY A 1 733 ? 118.837 125.535 120.118 1.00 13.81  ? 733 GLY A C     1 
ATOM 5278 O O     . GLY A 1 733 ? 118.093 126.507 120.295 1.00 15.62  ? 733 GLY A O     1 
ATOM 5279 N N     . THR A 1 734 ? 119.555 125.369 119.008 1.00 9.85   ? 734 THR A N     1 
ATOM 5280 C CA    . THR A 1 734 ? 119.690 126.416 118.004 1.00 8.17   ? 734 THR A CA    1 
ATOM 5281 C C     . THR A 1 734 ? 118.399 126.658 117.245 1.00 10.74  ? 734 THR A C     1 
ATOM 5282 O O     . THR A 1 734 ? 118.200 126.132 116.147 1.00 17.33  ? 734 THR A O     1 
ATOM 5283 C CB    . THR A 1 734 ? 120.795 126.057 117.022 1.00 15.56  ? 734 THR A CB    1 
ATOM 5284 O OG1   . THR A 1 734 ? 120.655 124.686 116.650 1.00 23.61  ? 734 THR A OG1   1 
ATOM 5285 C CG2   . THR A 1 734 ? 122.147 126.276 117.636 1.00 24.56  ? 734 THR A CG2   1 
ATOM 5286 N N     . THR A 1 735 ? 117.537 127.485 117.825 1.00 23.33  ? 735 THR A N     1 
ATOM 5287 C CA    . THR A 1 735 ? 116.240 127.768 117.236 1.00 22.82  ? 735 THR A CA    1 
ATOM 5288 C C     . THR A 1 735 ? 116.396 128.651 116.008 1.00 22.68  ? 735 THR A C     1 
ATOM 5289 O O     . THR A 1 735 ? 117.052 129.694 116.051 1.00 38.28  ? 735 THR A O     1 
ATOM 5290 C CB    . THR A 1 735 ? 115.343 128.460 118.263 1.00 30.26  ? 735 THR A CB    1 
ATOM 5291 O OG1   . THR A 1 735 ? 115.215 127.632 119.422 1.00 30.71  ? 735 THR A OG1   1 
ATOM 5292 C CG2   . THR A 1 735 ? 113.961 128.726 117.693 1.00 22.10  ? 735 THR A CG2   1 
ATOM 5293 N N     . VAL A 1 736 ? 115.804 128.222 114.900 1.00 23.16  ? 736 VAL A N     1 
ATOM 5294 C CA    . VAL A 1 736 ? 115.755 129.033 113.693 1.00 33.83  ? 736 VAL A CA    1 
ATOM 5295 C C     . VAL A 1 736 ? 114.292 129.153 113.284 1.00 31.76  ? 736 VAL A C     1 
ATOM 5296 O O     . VAL A 1 736 ? 113.635 128.143 113.015 1.00 31.32  ? 736 VAL A O     1 
ATOM 5297 C CB    . VAL A 1 736 ? 116.597 128.428 112.555 1.00 33.30  ? 736 VAL A CB    1 
ATOM 5298 C CG1   . VAL A 1 736 ? 116.276 129.096 111.237 1.00 33.05  ? 736 VAL A CG1   1 
ATOM 5299 C CG2   . VAL A 1 736 ? 118.079 128.535 112.866 1.00 23.38  ? 736 VAL A CG2   1 
ATOM 5300 N N     . ASP A 1 737 ? 113.778 130.382 113.246 1.00 30.67  ? 737 ASP A N     1 
ATOM 5301 C CA    . ASP A 1 737 ? 112.408 130.653 112.824 1.00 22.16  ? 737 ASP A CA    1 
ATOM 5302 C C     . ASP A 1 737 ? 112.369 131.540 111.582 1.00 34.62  ? 737 ASP A C     1 
ATOM 5303 O O     . ASP A 1 737 ? 111.436 131.434 110.776 1.00 36.22  ? 737 ASP A O     1 
ATOM 5304 C CB    . ASP A 1 737 ? 111.624 131.299 113.978 1.00 25.22  ? 737 ASP A CB    1 
ATOM 5305 C CG    . ASP A 1 737 ? 110.236 131.751 113.574 1.00 23.83  ? 737 ASP A CG    1 
ATOM 5306 O OD1   . ASP A 1 737 ? 109.516 130.974 112.921 1.00 23.13  ? 737 ASP A OD1   1 
ATOM 5307 O OD2   . ASP A 1 737 ? 109.879 132.901 113.885 1.00 21.54  ? 737 ASP A OD2   1 
ATOM 5308 N N     . THR A 1 738 ? 113.383 132.373 111.381 1.00 34.98  ? 738 THR A N     1 
ATOM 5309 C CA    . THR A 1 738 ? 113.438 133.310 110.272 1.00 28.92  ? 738 THR A CA    1 
ATOM 5310 C C     . THR A 1 738 ? 114.111 132.653 109.077 1.00 30.00  ? 738 THR A C     1 
ATOM 5311 O O     . THR A 1 738 ? 114.979 131.792 109.246 1.00 24.31  ? 738 THR A O     1 
ATOM 5312 C CB    . THR A 1 738 ? 114.220 134.568 110.661 1.00 33.19  ? 738 THR A CB    1 
ATOM 5313 O OG1   . THR A 1 738 ? 115.612 134.354 110.402 1.00 29.34  ? 738 THR A OG1   1 
ATOM 5314 C CG2   . THR A 1 738 ? 114.048 134.868 112.142 1.00 31.07  ? 738 THR A CG2   1 
ATOM 5315 N N     . LYS A 1 739 ? 113.670 133.027 107.879 1.00 35.61  ? 739 LYS A N     1 
ATOM 5316 C CA    . LYS A 1 739 ? 114.361 133.000 106.593 1.00 30.76  ? 739 LYS A CA    1 
ATOM 5317 C C     . LYS A 1 739 ? 114.489 131.586 105.979 1.00 40.89  ? 739 LYS A C     1 
ATOM 5318 O O     . LYS A 1 739 ? 114.593 131.481 104.758 1.00 52.45  ? 739 LYS A O     1 
ATOM 5319 C CB    . LYS A 1 739 ? 115.750 133.687 106.691 1.00 31.13  ? 739 LYS A CB    1 
ATOM 5320 C CG    . LYS A 1 739 ? 116.785 133.557 105.572 1.00 28.41  ? 739 LYS A CG    1 
ATOM 5321 C CD    . LYS A 1 739 ? 117.507 134.855 105.321 1.00 32.95  ? 739 LYS A CD    1 
ATOM 5322 C CE    . LYS A 1 739 ? 118.099 134.851 103.927 1.00 37.00  ? 739 LYS A CE    1 
ATOM 5323 N NZ    . LYS A 1 739 ? 117.035 134.758 102.886 1.00 35.57  ? 739 LYS A NZ    1 
ATOM 5324 N N     . ILE A 1 740 ? 114.317 130.502 106.733 1.00 31.62  ? 740 ILE A N     1 
ATOM 5325 C CA    . ILE A 1 740 ? 114.126 129.196 106.102 1.00 33.77  ? 740 ILE A CA    1 
ATOM 5326 C C     . ILE A 1 740 ? 112.877 128.483 106.588 1.00 30.26  ? 740 ILE A C     1 
ATOM 5327 O O     . ILE A 1 740 ? 112.329 127.642 105.856 1.00 38.80  ? 740 ILE A O     1 
ATOM 5328 C CB    . ILE A 1 740 ? 115.356 128.262 106.260 1.00 31.17  ? 740 ILE A CB    1 
ATOM 5329 C CG1   . ILE A 1 740 ? 115.504 127.729 107.681 1.00 38.25  ? 740 ILE A CG1   1 
ATOM 5330 C CG2   . ILE A 1 740 ? 116.670 128.881 105.755 1.00 26.73  ? 740 ILE A CG2   1 
ATOM 5331 C CD1   . ILE A 1 740 ? 116.230 126.441 107.717 1.00 35.41  ? 740 ILE A CD1   1 
ATOM 5332 N N     . THR A 1 741 ? 112.385 128.766 107.788 1.00 30.72  ? 741 THR A N     1 
ATOM 5333 C CA    . THR A 1 741 ? 111.115 128.258 108.268 1.00 23.67  ? 741 THR A CA    1 
ATOM 5334 C C     . THR A 1 741 ? 110.023 129.123 107.659 1.00 26.55  ? 741 THR A C     1 
ATOM 5335 O O     . THR A 1 741 ? 110.268 130.269 107.279 1.00 36.08  ? 741 THR A O     1 
ATOM 5336 C CB    . THR A 1 741 ? 111.067 128.287 109.795 1.00 38.12  ? 741 THR A CB    1 
ATOM 5337 O OG1   . THR A 1 741 ? 112.380 128.022 110.317 1.00 37.37  ? 741 THR A OG1   1 
ATOM 5338 C CG2   . THR A 1 741 ? 110.117 127.237 110.334 1.00 37.99  ? 741 THR A CG2   1 
ATOM 5339 N N     . HIS A 1 742 ? 108.826 128.543 107.535 1.00 27.96  ? 742 HIS A N     1 
ATOM 5340 C CA    . HIS A 1 742 ? 107.607 129.066 106.922 1.00 36.27  ? 742 HIS A CA    1 
ATOM 5341 C C     . HIS A 1 742 ? 107.264 130.315 107.730 1.00 46.66  ? 742 HIS A C     1 
ATOM 5342 O O     . HIS A 1 742 ? 107.175 130.244 108.962 1.00 43.06  ? 742 HIS A O     1 
ATOM 5343 C CB    . HIS A 1 742 ? 106.561 127.933 106.940 1.00 40.37  ? 742 HIS A CB    1 
ATOM 5344 C CG    . HIS A 1 742 ? 105.115 128.297 106.683 1.00 41.03  ? 742 HIS A CG    1 
ATOM 5345 N ND1   . HIS A 1 742 ? 104.186 127.308 106.433 1.00 41.73  ? 742 HIS A ND1   1 
ATOM 5346 C CD2   . HIS A 1 742 ? 104.440 129.471 106.574 1.00 43.09  ? 742 HIS A CD2   1 
ATOM 5347 C CE1   . HIS A 1 742 ? 103.001 127.852 106.227 1.00 46.46  ? 742 HIS A CE1   1 
ATOM 5348 N NE2   . HIS A 1 742 ? 103.128 129.164 106.307 1.00 46.89  ? 742 HIS A NE2   1 
ATOM 5349 N N     . PRO A 1 743 ? 107.112 131.485 107.083 1.00 50.79  ? 743 PRO A N     1 
ATOM 5350 C CA    . PRO A 1 743 ? 106.966 132.724 107.859 1.00 49.44  ? 743 PRO A CA    1 
ATOM 5351 C C     . PRO A 1 743 ? 105.597 132.852 108.486 1.00 50.58  ? 743 PRO A C     1 
ATOM 5352 O O     . PRO A 1 743 ? 105.428 133.188 109.662 1.00 48.44  ? 743 PRO A O     1 
ATOM 5353 C CB    . PRO A 1 743 ? 107.086 133.792 106.780 1.00 48.30  ? 743 PRO A CB    1 
ATOM 5354 C CG    . PRO A 1 743 ? 108.047 133.277 105.867 1.00 49.33  ? 743 PRO A CG    1 
ATOM 5355 C CD    . PRO A 1 743 ? 107.849 131.766 105.830 1.00 49.05  ? 743 PRO A CD    1 
ATOM 5356 N N     . THR A 1 744 ? 104.609 132.541 107.653 1.00 48.89  ? 744 THR A N     1 
ATOM 5357 C CA    . THR A 1 744 ? 103.241 133.004 107.810 1.00 44.88  ? 744 THR A CA    1 
ATOM 5358 C C     . THR A 1 744 ? 102.477 132.255 108.884 1.00 46.64  ? 744 THR A C     1 
ATOM 5359 O O     . THR A 1 744 ? 101.360 132.661 109.222 1.00 48.11  ? 744 THR A O     1 
ATOM 5360 C CB    . THR A 1 744 ? 102.517 132.875 106.472 1.00 43.72  ? 744 THR A CB    1 
ATOM 5361 O OG1   . THR A 1 744 ? 102.001 131.546 106.343 1.00 36.19  ? 744 THR A OG1   1 
ATOM 5362 C CG2   . THR A 1 744 ? 103.466 133.156 105.300 1.00 48.98  ? 744 THR A CG2   1 
ATOM 5363 N N     . GLU A 1 745 ? 103.038 131.180 109.416 1.00 46.24  ? 745 GLU A N     1 
ATOM 5364 C CA    . GLU A 1 745 ? 102.367 130.362 110.408 1.00 44.23  ? 745 GLU A CA    1 
ATOM 5365 C C     . GLU A 1 745 ? 103.214 130.327 111.679 1.00 45.50  ? 745 GLU A C     1 
ATOM 5366 O O     . GLU A 1 745 ? 104.241 131.000 111.787 1.00 40.59  ? 745 GLU A O     1 
ATOM 5367 C CB    . GLU A 1 745 ? 102.102 128.968 109.832 1.00 34.87  ? 745 GLU A CB    1 
ATOM 5368 C CG    . GLU A 1 745 ? 100.892 128.928 108.922 1.00 35.34  ? 745 GLU A CG    1 
ATOM 5369 C CD    . GLU A 1 745 ? 100.161 127.613 108.977 1.00 43.52  ? 745 GLU A CD    1 
ATOM 5370 O OE1   . GLU A 1 745 ? 100.536 126.694 108.222 1.00 43.46  ? 745 GLU A OE1   1 
ATOM 5371 O OE2   . GLU A 1 745 ? 99.201  127.500 109.766 1.00 59.97  ? 745 GLU A OE2   1 
ATOM 5372 N N     . PHE A 1 746 ? 102.763 129.534 112.644 1.00 53.57  ? 746 PHE A N     1 
ATOM 5373 C CA    . PHE A 1 746 ? 103.367 129.426 113.969 1.00 49.42  ? 746 PHE A CA    1 
ATOM 5374 C C     . PHE A 1 746 ? 104.282 128.206 113.960 1.00 44.04  ? 746 PHE A C     1 
ATOM 5375 O O     . PHE A 1 746 ? 103.801 127.077 113.856 1.00 36.36  ? 746 PHE A O     1 
ATOM 5376 C CB    . PHE A 1 746 ? 102.258 129.326 115.018 1.00 43.12  ? 746 PHE A CB    1 
ATOM 5377 C CG    . PHE A 1 746 ? 102.661 129.756 116.397 1.00 35.49  ? 746 PHE A CG    1 
ATOM 5378 C CD1   . PHE A 1 746 ? 103.828 130.474 116.611 1.00 37.96  ? 746 PHE A CD1   1 
ATOM 5379 C CD2   . PHE A 1 746 ? 101.814 129.524 117.467 1.00 37.39  ? 746 PHE A CD2   1 
ATOM 5380 C CE1   . PHE A 1 746 ? 104.184 130.882 117.888 1.00 39.53  ? 746 PHE A CE1   1 
ATOM 5381 C CE2   . PHE A 1 746 ? 102.159 129.935 118.742 1.00 43.35  ? 746 PHE A CE2   1 
ATOM 5382 C CZ    . PHE A 1 746 ? 103.347 130.617 118.951 1.00 34.62  ? 746 PHE A CZ    1 
ATOM 5383 N N     . ASP A 1 747 ? 105.596 128.431 114.034 1.00 31.07  ? 747 ASP A N     1 
ATOM 5384 C CA    . ASP A 1 747 ? 106.576 127.354 113.903 1.00 19.82  ? 747 ASP A CA    1 
ATOM 5385 C C     . ASP A 1 747 ? 107.931 127.857 114.371 1.00 13.47  ? 747 ASP A C     1 
ATOM 5386 O O     . ASP A 1 747 ? 108.116 129.055 114.599 1.00 41.97  ? 747 ASP A O     1 
ATOM 5387 C CB    . ASP A 1 747 ? 106.694 126.857 112.464 1.00 27.85  ? 747 ASP A CB    1 
ATOM 5388 C CG    . ASP A 1 747 ? 106.556 127.969 111.450 1.00 43.27  ? 747 ASP A CG    1 
ATOM 5389 O OD1   . ASP A 1 747 ? 106.451 129.139 111.860 1.00 46.45  ? 747 ASP A OD1   1 
ATOM 5390 O OD2   . ASP A 1 747 ? 106.518 127.667 110.241 1.00 47.34  ? 747 ASP A OD2   1 
ATOM 5391 N N     . PHE A 1 748 ? 108.872 126.917 114.510 1.00 0.00   ? 748 PHE A N     1 
ATOM 5392 C CA    . PHE A 1 748 ? 110.305 127.147 114.674 1.00 11.15  ? 748 PHE A CA    1 
ATOM 5393 C C     . PHE A 1 748 ? 111.026 125.822 114.506 1.00 0.00   ? 748 PHE A C     1 
ATOM 5394 O O     . PHE A 1 748 ? 110.461 124.772 114.800 1.00 1.08   ? 748 PHE A O     1 
ATOM 5395 C CB    . PHE A 1 748 ? 110.678 127.773 116.038 1.00 28.13  ? 748 PHE A CB    1 
ATOM 5396 C CG    . PHE A 1 748 ? 110.351 126.923 117.248 1.00 21.58  ? 748 PHE A CG    1 
ATOM 5397 C CD1   . PHE A 1 748 ? 109.077 126.918 117.795 1.00 19.76  ? 748 PHE A CD1   1 
ATOM 5398 C CD2   . PHE A 1 748 ? 111.340 126.183 117.881 1.00 25.43  ? 748 PHE A CD2   1 
ATOM 5399 C CE1   . PHE A 1 748 ? 108.795 126.151 118.914 1.00 14.89  ? 748 PHE A CE1   1 
ATOM 5400 C CE2   . PHE A 1 748 ? 111.060 125.424 118.991 1.00 12.60  ? 748 PHE A CE2   1 
ATOM 5401 C CZ    . PHE A 1 748 ? 109.792 125.406 119.509 1.00 3.94   ? 748 PHE A CZ    1 
ATOM 5402 N N     . TYR A 1 749 ? 112.264 125.876 114.024 1.00 9.51   ? 749 TYR A N     1 
ATOM 5403 C CA    . TYR A 1 749 ? 113.122 124.704 114.112 1.00 15.94  ? 749 TYR A CA    1 
ATOM 5404 C C     . TYR A 1 749 ? 113.787 124.680 115.472 1.00 3.88   ? 749 TYR A C     1 
ATOM 5405 O O     . TYR A 1 749 ? 113.926 125.708 116.129 1.00 22.90  ? 749 TYR A O     1 
ATOM 5406 C CB    . TYR A 1 749 ? 114.228 124.673 113.042 1.00 26.38  ? 749 TYR A CB    1 
ATOM 5407 C CG    . TYR A 1 749 ? 113.807 124.259 111.647 1.00 31.56  ? 749 TYR A CG    1 
ATOM 5408 C CD1   . TYR A 1 749 ? 112.624 124.710 111.086 1.00 32.21  ? 749 TYR A CD1   1 
ATOM 5409 C CD2   . TYR A 1 749 ? 114.527 123.298 110.953 1.00 31.07  ? 749 TYR A CD2   1 
ATOM 5410 C CE1   . TYR A 1 749 ? 112.219 124.309 109.840 1.00 21.73  ? 749 TYR A CE1   1 
ATOM 5411 C CE2   . TYR A 1 749 ? 114.116 122.870 109.706 1.00 36.66  ? 749 TYR A CE2   1 
ATOM 5412 C CZ    . TYR A 1 749 ? 112.954 123.386 109.156 1.00 29.71  ? 749 TYR A CZ    1 
ATOM 5413 O OH    . TYR A 1 749 ? 112.488 123.004 107.921 1.00 19.23  ? 749 TYR A OH    1 
ATOM 5414 N N     . LEU A 1 750 ? 114.220 123.496 115.883 1.00 0.00   ? 750 LEU A N     1 
ATOM 5415 C CA    . LEU A 1 750 ? 115.053 123.373 117.067 1.00 13.18  ? 750 LEU A CA    1 
ATOM 5416 C C     . LEU A 1 750 ? 115.879 122.111 116.931 1.00 14.19  ? 750 LEU A C     1 
ATOM 5417 O O     . LEU A 1 750 ? 115.364 121.074 116.515 1.00 28.13  ? 750 LEU A O     1 
ATOM 5418 C CB    . LEU A 1 750 ? 114.218 123.336 118.351 1.00 21.67  ? 750 LEU A CB    1 
ATOM 5419 C CG    . LEU A 1 750 ? 114.982 123.675 119.634 1.00 20.36  ? 750 LEU A CG    1 
ATOM 5420 C CD1   . LEU A 1 750 ? 114.222 124.651 120.506 1.00 18.40  ? 750 LEU A CD1   1 
ATOM 5421 C CD2   . LEU A 1 750 ? 115.243 122.424 120.406 1.00 24.12  ? 750 LEU A CD2   1 
ATOM 5422 N N     . CYS A 1 751 ? 117.159 122.211 117.255 1.00 11.62  ? 751 CYS A N     1 
ATOM 5423 C CA    . CYS A 1 751 ? 118.053 121.066 117.341 1.00 13.13  ? 751 CYS A CA    1 
ATOM 5424 C C     . CYS A 1 751 ? 118.581 121.070 118.762 1.00 27.31  ? 751 CYS A C     1 
ATOM 5425 O O     . CYS A 1 751 ? 119.353 121.951 119.137 1.00 30.56  ? 751 CYS A O     1 
ATOM 5426 C CB    . CYS A 1 751 ? 119.174 121.142 116.339 1.00 17.04  ? 751 CYS A CB    1 
ATOM 5427 S SG    . CYS A 1 751 ? 120.592 120.111 116.764 1.00 8.82   ? 751 CYS A SG    1 
ATOM 5428 N N     . SER A 1 752 ? 118.148 120.095 119.552 1.00 27.80  ? 752 SER A N     1 
ATOM 5429 C CA    . SER A 1 752 ? 118.598 119.902 120.927 1.00 27.16  ? 752 SER A CA    1 
ATOM 5430 C C     . SER A 1 752 ? 119.442 118.651 121.069 1.00 24.24  ? 752 SER A C     1 
ATOM 5431 O O     . SER A 1 752 ? 119.188 117.804 121.918 1.00 37.96  ? 752 SER A O     1 
ATOM 5432 C CB    . SER A 1 752 ? 117.409 119.892 121.872 1.00 24.38  ? 752 SER A CB    1 
ATOM 5433 O OG    . SER A 1 752 ? 116.328 119.216 121.283 1.00 26.02  ? 752 SER A OG    1 
ATOM 5434 N N     . HIS A 1 753 ? 120.424 118.510 120.198 1.00 38.67  ? 753 HIS A N     1 
ATOM 5435 C CA    . HIS A 1 753 ? 121.209 117.307 120.010 1.00 45.24  ? 753 HIS A CA    1 
ATOM 5436 C C     . HIS A 1 753 ? 122.666 117.514 120.406 1.00 54.53  ? 753 HIS A C     1 
ATOM 5437 O O     . HIS A 1 753 ? 123.053 118.556 120.949 1.00 56.90  ? 753 HIS A O     1 
ATOM 5438 C CB    . HIS A 1 753 ? 121.087 116.884 118.552 1.00 45.30  ? 753 HIS A CB    1 
ATOM 5439 C CG    . HIS A 1 753 ? 119.693 116.972 118.029 1.00 47.45  ? 753 HIS A CG    1 
ATOM 5440 N ND1   . HIS A 1 753 ? 119.370 117.569 116.831 1.00 54.68  ? 753 HIS A ND1   1 
ATOM 5441 C CD2   . HIS A 1 753 ? 118.534 116.519 118.546 1.00 41.68  ? 753 HIS A CD2   1 
ATOM 5442 C CE1   . HIS A 1 753 ? 118.065 117.487 116.641 1.00 49.49  ? 753 HIS A CE1   1 
ATOM 5443 N NE2   . HIS A 1 753 ? 117.534 116.851 117.668 1.00 41.33  ? 753 HIS A NE2   1 
ATOM 5444 N N     . ALA A 1 754 ? 123.478 116.493 120.132 1.00 59.46  ? 754 ALA A N     1 
ATOM 5445 C CA    . ALA A 1 754 ? 124.927 116.562 120.262 1.00 62.23  ? 754 ALA A CA    1 
ATOM 5446 C C     . ALA A 1 754 ? 125.579 115.695 119.191 1.00 59.87  ? 754 ALA A C     1 
ATOM 5447 O O     . ALA A 1 754 ? 124.924 115.303 118.219 1.00 58.45  ? 754 ALA A O     1 
ATOM 5448 C CB    . ALA A 1 754 ? 125.372 116.125 121.659 1.00 62.91  ? 754 ALA A CB    1 
ATOM 5449 N N     . GLY A 1 755 ? 126.862 115.386 119.361 1.00 65.65  ? 755 GLY A N     1 
ATOM 5450 C CA    . GLY A 1 755 ? 127.568 114.557 118.403 1.00 68.79  ? 755 GLY A CA    1 
ATOM 5451 C C     . GLY A 1 755 ? 127.267 113.076 118.528 1.00 63.86  ? 755 GLY A C     1 
ATOM 5452 O O     . GLY A 1 755 ? 127.702 112.423 119.482 1.00 60.06  ? 755 GLY A O     1 
ATOM 5453 N N     . ILE A 1 756 ? 126.509 112.538 117.573 1.00 59.05  ? 756 ILE A N     1 
ATOM 5454 C CA    . ILE A 1 756 ? 126.126 111.129 117.540 1.00 64.81  ? 756 ILE A CA    1 
ATOM 5455 C C     . ILE A 1 756 ? 126.293 110.626 116.111 1.00 67.50  ? 756 ILE A C     1 
ATOM 5456 O O     . ILE A 1 756 ? 125.730 111.216 115.179 1.00 65.83  ? 756 ILE A O     1 
ATOM 5457 C CB    . ILE A 1 756 ? 124.679 110.921 118.026 1.00 64.85  ? 756 ILE A CB    1 
ATOM 5458 C CG1   . ILE A 1 756 ? 124.586 111.073 119.546 1.00 62.88  ? 756 ILE A CG1   1 
ATOM 5459 C CG2   . ILE A 1 756 ? 124.109 109.595 117.542 1.00 62.49  ? 756 ILE A CG2   1 
ATOM 5460 C CD1   . ILE A 1 756 ? 124.960 109.856 120.328 1.00 60.94  ? 756 ILE A CD1   1 
ATOM 5461 N N     . GLN A 1 757 ? 127.169 109.625 115.925 1.00 72.72  ? 757 GLN A N     1 
ATOM 5462 C CA    . GLN A 1 757 ? 127.269 108.740 114.754 1.00 71.60  ? 757 GLN A CA    1 
ATOM 5463 C C     . GLN A 1 757 ? 127.799 109.405 113.473 1.00 74.43  ? 757 GLN A C     1 
ATOM 5464 O O     . GLN A 1 757 ? 128.357 108.731 112.596 1.00 75.89  ? 757 GLN A O     1 
ATOM 5465 C CB    . GLN A 1 757 ? 125.881 108.076 114.547 1.00 66.86  ? 757 GLN A CB    1 
ATOM 5466 C CG    . GLN A 1 757 ? 125.395 107.726 113.129 1.00 64.87  ? 757 GLN A CG    1 
ATOM 5467 C CD    . GLN A 1 757 ? 125.924 106.406 112.601 1.00 69.78  ? 757 GLN A CD    1 
ATOM 5468 O OE1   . GLN A 1 757 ? 127.096 106.075 112.765 1.00 74.97  ? 757 GLN A OE1   1 
ATOM 5469 N NE2   . GLN A 1 757 ? 125.046 105.633 111.972 1.00 71.96  ? 757 GLN A NE2   1 
ATOM 5470 N N     . GLY A 1 758 ? 127.794 110.731 113.430 1.00 69.60  ? 758 GLY A N     1 
ATOM 5471 C CA    . GLY A 1 758 ? 127.990 111.483 112.210 1.00 65.61  ? 758 GLY A CA    1 
ATOM 5472 C C     . GLY A 1 758 ? 126.604 111.751 111.666 1.00 64.94  ? 758 GLY A C     1 
ATOM 5473 O O     . GLY A 1 758 ? 126.022 110.887 111.003 1.00 64.20  ? 758 GLY A O     1 
ATOM 5474 N N     . THR A 1 759 ? 126.042 112.923 111.954 1.00 52.23  ? 759 THR A N     1 
ATOM 5475 C CA    . THR A 1 759 ? 124.621 113.164 111.740 1.00 47.29  ? 759 THR A CA    1 
ATOM 5476 C C     . THR A 1 759 ? 124.399 114.667 111.706 1.00 48.04  ? 759 THR A C     1 
ATOM 5477 O O     . THR A 1 759 ? 124.942 115.392 112.542 1.00 49.02  ? 759 THR A O     1 
ATOM 5478 C CB    . THR A 1 759 ? 123.744 112.543 112.850 1.00 52.83  ? 759 THR A CB    1 
ATOM 5479 O OG1   . THR A 1 759 ? 124.007 111.143 113.014 1.00 55.05  ? 759 THR A OG1   1 
ATOM 5480 C CG2   . THR A 1 759 ? 122.309 112.670 112.518 1.00 54.98  ? 759 THR A CG2   1 
ATOM 5481 N N     . SER A 1 760 ? 123.626 115.134 110.730 1.00 41.86  ? 760 SER A N     1 
ATOM 5482 C CA    . SER A 1 760 ? 123.145 116.511 110.703 1.00 45.47  ? 760 SER A CA    1 
ATOM 5483 C C     . SER A 1 760 ? 121.626 116.467 110.824 1.00 44.24  ? 760 SER A C     1 
ATOM 5484 O O     . SER A 1 760 ? 120.967 115.792 110.026 1.00 39.58  ? 760 SER A O     1 
ATOM 5485 C CB    . SER A 1 760 ? 123.589 117.213 109.432 1.00 47.81  ? 760 SER A CB    1 
ATOM 5486 O OG    . SER A 1 760 ? 122.538 117.237 108.490 1.00 39.52  ? 760 SER A OG    1 
ATOM 5487 N N     . ARG A 1 761 ? 121.073 117.194 111.819 1.00 46.28  ? 761 ARG A N     1 
ATOM 5488 C CA    . ARG A 1 761 ? 119.635 117.154 112.114 1.00 46.55  ? 761 ARG A CA    1 
ATOM 5489 C C     . ARG A 1 761 ? 119.141 118.276 113.019 1.00 39.10  ? 761 ARG A C     1 
ATOM 5490 O O     . ARG A 1 761 ? 119.812 118.647 113.985 1.00 31.66  ? 761 ARG A O     1 
ATOM 5491 C CB    . ARG A 1 761 ? 119.242 115.808 112.742 1.00 42.05  ? 761 ARG A CB    1 
ATOM 5492 C CG    . ARG A 1 761 ? 119.575 115.451 114.229 1.00 44.18  ? 761 ARG A CG    1 
ATOM 5493 C CD    . ARG A 1 761 ? 121.065 115.404 114.577 1.00 54.75  ? 761 ARG A CD    1 
ATOM 5494 N NE    . ARG A 1 761 ? 121.395 114.457 115.639 1.00 57.36  ? 761 ARG A NE    1 
ATOM 5495 C CZ    . ARG A 1 761 ? 122.476 114.531 116.404 1.00 49.37  ? 761 ARG A CZ    1 
ATOM 5496 N NH1   . ARG A 1 761 ? 123.338 115.525 116.290 1.00 42.35  ? 761 ARG A NH1   1 
ATOM 5497 N NH2   . ARG A 1 761 ? 122.684 113.597 117.325 1.00 51.96  ? 761 ARG A NH2   1 
ATOM 5498 N N     . PRO A 1 762 ? 118.033 118.915 112.669 1.00 34.55  ? 762 PRO A N     1 
ATOM 5499 C CA    . PRO A 1 762 ? 117.097 119.447 113.647 1.00 28.39  ? 762 PRO A CA    1 
ATOM 5500 C C     . PRO A 1 762 ? 115.877 118.590 114.012 1.00 24.77  ? 762 PRO A C     1 
ATOM 5501 O O     . PRO A 1 762 ? 115.853 117.358 113.868 1.00 33.42  ? 762 PRO A O     1 
ATOM 5502 C CB    . PRO A 1 762 ? 116.756 120.789 112.974 1.00 29.39  ? 762 PRO A CB    1 
ATOM 5503 C CG    . PRO A 1 762 ? 116.989 120.388 111.428 1.00 37.52  ? 762 PRO A CG    1 
ATOM 5504 C CD    . PRO A 1 762 ? 117.103 118.945 111.500 1.00 37.02  ? 762 PRO A CD    1 
ATOM 5505 N N     . SER A 1 763 ? 114.949 119.236 114.713 1.00 22.53  ? 763 SER A N     1 
ATOM 5506 C CA    . SER A 1 763 ? 113.634 118.677 115.018 1.00 17.07  ? 763 SER A CA    1 
ATOM 5507 C C     . SER A 1 763 ? 112.604 119.788 114.879 1.00 15.75  ? 763 SER A C     1 
ATOM 5508 O O     . SER A 1 763 ? 112.505 120.652 115.754 1.00 26.47  ? 763 SER A O     1 
ATOM 5509 C CB    . SER A 1 763 ? 113.602 118.092 116.428 1.00 12.36  ? 763 SER A CB    1 
ATOM 5510 O OG    . SER A 1 763 ? 114.679 117.204 116.647 1.00 18.52  ? 763 SER A OG    1 
ATOM 5511 N N     . HIS A 1 764 ? 111.832 119.757 113.797 1.00 13.41  ? 764 HIS A N     1 
ATOM 5512 C CA    . HIS A 1 764 ? 110.945 120.864 113.440 1.00 13.00  ? 764 HIS A CA    1 
ATOM 5513 C C     . HIS A 1 764 ? 109.720 120.855 114.339 1.00 6.35   ? 764 HIS A C     1 
ATOM 5514 O O     . HIS A 1 764 ? 108.811 120.046 114.164 1.00 26.76  ? 764 HIS A O     1 
ATOM 5515 C CB    . HIS A 1 764 ? 110.566 120.790 111.967 1.00 18.94  ? 764 HIS A CB    1 
ATOM 5516 C CG    . HIS A 1 764 ? 109.624 121.864 111.527 1.00 22.31  ? 764 HIS A CG    1 
ATOM 5517 N ND1   . HIS A 1 764 ? 109.868 123.199 111.747 1.00 28.76  ? 764 HIS A ND1   1 
ATOM 5518 C CD2   . HIS A 1 764 ? 108.474 121.808 110.814 1.00 23.85  ? 764 HIS A CD2   1 
ATOM 5519 C CE1   . HIS A 1 764 ? 108.895 123.919 111.221 1.00 33.24  ? 764 HIS A CE1   1 
ATOM 5520 N NE2   . HIS A 1 764 ? 108.033 123.098 110.651 1.00 31.59  ? 764 HIS A NE2   1 
ATOM 5521 N N     . TYR A 1 765 ? 109.684 121.790 115.289 1.00 1.36   ? 765 TYR A N     1 
ATOM 5522 C CA    . TYR A 1 765 ? 108.604 121.883 116.269 1.00 17.50  ? 765 TYR A CA    1 
ATOM 5523 C C     . TYR A 1 765 ? 107.535 122.847 115.765 1.00 11.83  ? 765 TYR A C     1 
ATOM 5524 O O     . TYR A 1 765 ? 107.419 123.987 116.209 1.00 16.96  ? 765 TYR A O     1 
ATOM 5525 C CB    . TYR A 1 765 ? 109.132 122.362 117.610 1.00 22.44  ? 765 TYR A CB    1 
ATOM 5526 C CG    . TYR A 1 765 ? 110.095 121.464 118.339 1.00 17.77  ? 765 TYR A CG    1 
ATOM 5527 C CD1   . TYR A 1 765 ? 110.235 120.130 118.024 1.00 27.43  ? 765 TYR A CD1   1 
ATOM 5528 C CD2   . TYR A 1 765 ? 110.896 121.982 119.328 1.00 13.40  ? 765 TYR A CD2   1 
ATOM 5529 C CE1   . TYR A 1 765 ? 111.124 119.342 118.707 1.00 24.20  ? 765 TYR A CE1   1 
ATOM 5530 C CE2   . TYR A 1 765 ? 111.778 121.209 120.006 1.00 13.85  ? 765 TYR A CE2   1 
ATOM 5531 C CZ    . TYR A 1 765 ? 111.890 119.898 119.695 1.00 18.99  ? 765 TYR A CZ    1 
ATOM 5532 O OH    . TYR A 1 765 ? 112.794 119.161 120.392 1.00 34.46  ? 765 TYR A OH    1 
ATOM 5533 N N     . HIS A 1 766 ? 106.737 122.376 114.815 1.00 1.87   ? 766 HIS A N     1 
ATOM 5534 C CA    . HIS A 1 766 ? 105.711 123.239 114.235 1.00 12.55  ? 766 HIS A CA    1 
ATOM 5535 C C     . HIS A 1 766 ? 104.522 123.291 115.189 1.00 10.00  ? 766 HIS A C     1 
ATOM 5536 O O     . HIS A 1 766 ? 103.612 122.461 115.149 1.00 13.21  ? 766 HIS A O     1 
ATOM 5537 C CB    . HIS A 1 766 ? 105.306 122.751 112.852 1.00 10.71  ? 766 HIS A CB    1 
ATOM 5538 C CG    . HIS A 1 766 ? 104.665 123.807 112.006 1.00 19.89  ? 766 HIS A CG    1 
ATOM 5539 N ND1   . HIS A 1 766 ? 105.217 124.260 110.829 1.00 12.75  ? 766 HIS A ND1   1 
ATOM 5540 C CD2   . HIS A 1 766 ? 103.512 124.496 112.168 1.00 27.86  ? 766 HIS A CD2   1 
ATOM 5541 C CE1   . HIS A 1 766 ? 104.433 125.185 110.305 1.00 20.44  ? 766 HIS A CE1   1 
ATOM 5542 N NE2   . HIS A 1 766 ? 103.392 125.348 111.099 1.00 23.69  ? 766 HIS A NE2   1 
ATOM 5543 N N     . VAL A 1 767 ? 104.514 124.316 116.046 1.00 8.51   ? 767 VAL A N     1 
ATOM 5544 C CA    . VAL A 1 767 ? 103.485 124.406 117.077 1.00 13.02  ? 767 VAL A CA    1 
ATOM 5545 C C     . VAL A 1 767 ? 102.170 124.839 116.424 1.00 23.54  ? 767 VAL A C     1 
ATOM 5546 O O     . VAL A 1 767 ? 102.095 125.835 115.698 1.00 34.51  ? 767 VAL A O     1 
ATOM 5547 C CB    . VAL A 1 767 ? 103.969 125.286 118.261 1.00 21.00  ? 767 VAL A CB    1 
ATOM 5548 C CG1   . VAL A 1 767 ? 105.383 124.948 118.605 1.00 18.70  ? 767 VAL A CG1   1 
ATOM 5549 C CG2   . VAL A 1 767 ? 103.987 126.769 118.017 1.00 24.77  ? 767 VAL A CG2   1 
ATOM 5550 N N     . LEU A 1 768 ? 101.154 123.998 116.540 1.00 22.69  ? 768 LEU A N     1 
ATOM 5551 C CA    . LEU A 1 768 ? 99.957  124.238 115.749 1.00 31.85  ? 768 LEU A CA    1 
ATOM 5552 C C     . LEU A 1 768 ? 98.890  125.055 116.450 1.00 31.69  ? 768 LEU A C     1 
ATOM 5553 O O     . LEU A 1 768 ? 98.019  125.595 115.764 1.00 39.76  ? 768 LEU A O     1 
ATOM 5554 C CB    . LEU A 1 768 ? 99.348  122.930 115.251 1.00 30.53  ? 768 LEU A CB    1 
ATOM 5555 C CG    . LEU A 1 768 ? 100.058 122.210 114.114 1.00 24.16  ? 768 LEU A CG    1 
ATOM 5556 C CD1   . LEU A 1 768 ? 99.136  121.131 113.609 1.00 23.45  ? 768 LEU A CD1   1 
ATOM 5557 C CD2   . LEU A 1 768 ? 100.356 123.189 113.002 1.00 28.59  ? 768 LEU A CD2   1 
ATOM 5558 N N     . TRP A 1 769 ? 98.929  125.179 117.772 1.00 34.55  ? 769 TRP A N     1 
ATOM 5559 C CA    . TRP A 1 769 ? 97.907  125.981 118.428 1.00 35.72  ? 769 TRP A CA    1 
ATOM 5560 C C     . TRP A 1 769 ? 98.457  126.509 119.739 1.00 48.17  ? 769 TRP A C     1 
ATOM 5561 O O     . TRP A 1 769 ? 99.094  125.777 120.499 1.00 56.11  ? 769 TRP A O     1 
ATOM 5562 C CB    . TRP A 1 769 ? 96.625  125.167 118.655 1.00 38.98  ? 769 TRP A CB    1 
ATOM 5563 C CG    . TRP A 1 769 ? 95.603  125.774 119.536 1.00 46.48  ? 769 TRP A CG    1 
ATOM 5564 C CD1   . TRP A 1 769 ? 95.513  125.669 120.894 1.00 50.24  ? 769 TRP A CD1   1 
ATOM 5565 C CD2   . TRP A 1 769 ? 94.485  126.558 119.120 1.00 50.82  ? 769 TRP A CD2   1 
ATOM 5566 N NE1   . TRP A 1 769 ? 94.419  126.355 121.348 1.00 56.32  ? 769 TRP A NE1   1 
ATOM 5567 C CE2   . TRP A 1 769 ? 93.768  126.911 120.279 1.00 56.19  ? 769 TRP A CE2   1 
ATOM 5568 C CE3   . TRP A 1 769 ? 94.022  127.002 117.878 1.00 47.64  ? 769 TRP A CE3   1 
ATOM 5569 C CZ2   . TRP A 1 769 ? 92.613  127.689 120.234 1.00 52.77  ? 769 TRP A CZ2   1 
ATOM 5570 C CZ3   . TRP A 1 769 ? 92.877  127.775 117.835 1.00 54.03  ? 769 TRP A CZ3   1 
ATOM 5571 C CH2   . TRP A 1 769 ? 92.184  128.111 119.005 1.00 53.71  ? 769 TRP A CH2   1 
ATOM 5572 N N     . ASP A 1 770 ? 98.211  127.796 119.978 1.00 51.67  ? 770 ASP A N     1 
ATOM 5573 C CA    . ASP A 1 770 ? 98.361  128.409 121.293 1.00 47.59  ? 770 ASP A CA    1 
ATOM 5574 C C     . ASP A 1 770 ? 97.039  129.094 121.596 1.00 50.92  ? 770 ASP A C     1 
ATOM 5575 O O     . ASP A 1 770 ? 96.554  129.876 120.773 1.00 53.21  ? 770 ASP A O     1 
ATOM 5576 C CB    . ASP A 1 770 ? 99.512  129.414 121.322 1.00 46.92  ? 770 ASP A CB    1 
ATOM 5577 C CG    . ASP A 1 770 ? 100.817 128.799 121.782 1.00 45.50  ? 770 ASP A CG    1 
ATOM 5578 O OD1   . ASP A 1 770 ? 100.886 127.569 121.929 1.00 35.75  ? 770 ASP A OD1   1 
ATOM 5579 O OD2   . ASP A 1 770 ? 101.786 129.550 121.989 1.00 59.91  ? 770 ASP A OD2   1 
ATOM 5580 N N     . ASP A 1 771 ? 96.455  128.799 122.760 1.00 59.50  ? 771 ASP A N     1 
ATOM 5581 C CA    . ASP A 1 771 ? 95.095  129.258 123.039 1.00 56.06  ? 771 ASP A CA    1 
ATOM 5582 C C     . ASP A 1 771 ? 95.068  130.733 123.412 1.00 58.27  ? 771 ASP A C     1 
ATOM 5583 O O     . ASP A 1 771 ? 94.395  131.537 122.757 1.00 61.38  ? 771 ASP A O     1 
ATOM 5584 C CB    . ASP A 1 771 ? 94.474  128.413 124.148 1.00 54.48  ? 771 ASP A CB    1 
ATOM 5585 C CG    . ASP A 1 771 ? 92.966  128.316 124.030 1.00 56.52  ? 771 ASP A CG    1 
ATOM 5586 O OD1   . ASP A 1 771 ? 92.386  129.030 123.186 1.00 55.29  ? 771 ASP A OD1   1 
ATOM 5587 O OD2   . ASP A 1 771 ? 92.360  127.524 124.781 1.00 60.93  ? 771 ASP A OD2   1 
ATOM 5588 N N     . ASN A 1 772 ? 95.799  131.110 124.455 1.00 55.27  ? 772 ASN A N     1 
ATOM 5589 C CA    . ASN A 1 772 ? 95.824  132.488 124.921 1.00 58.24  ? 772 ASN A CA    1 
ATOM 5590 C C     . ASN A 1 772 ? 96.842  133.338 124.175 1.00 58.24  ? 772 ASN A C     1 
ATOM 5591 O O     . ASN A 1 772 ? 96.964  134.531 124.480 1.00 58.90  ? 772 ASN A O     1 
ATOM 5592 C CB    . ASN A 1 772 ? 96.116  132.522 126.421 1.00 59.21  ? 772 ASN A CB    1 
ATOM 5593 C CG    . ASN A 1 772 ? 95.356  131.457 127.183 1.00 61.75  ? 772 ASN A CG    1 
ATOM 5594 O OD1   . ASN A 1 772 ? 95.614  130.264 127.025 1.00 56.79  ? 772 ASN A OD1   1 
ATOM 5595 N ND2   . ASN A 1 772 ? 94.414  131.881 128.015 1.00 63.67  ? 772 ASN A ND2   1 
ATOM 5596 N N     . ARG A 1 773 ? 97.561  132.734 123.221 1.00 61.14  ? 773 ARG A N     1 
ATOM 5597 C CA    . ARG A 1 773 ? 98.559  133.368 122.354 1.00 60.24  ? 773 ARG A CA    1 
ATOM 5598 C C     . ARG A 1 773 ? 99.685  134.009 123.167 1.00 58.21  ? 773 ARG A C     1 
ATOM 5599 O O     . ARG A 1 773 ? 99.893  135.224 123.151 1.00 61.38  ? 773 ARG A O     1 
ATOM 5600 C CB    . ARG A 1 773 ? 97.912  134.376 121.395 1.00 59.93  ? 773 ARG A CB    1 
ATOM 5601 C CG    . ARG A 1 773 ? 98.346  134.218 119.945 1.00 59.70  ? 773 ARG A CG    1 
ATOM 5602 C CD    . ARG A 1 773 ? 97.902  132.873 119.377 1.00 57.26  ? 773 ARG A CD    1 
ATOM 5603 N NE    . ARG A 1 773 ? 96.512  132.562 119.695 1.00 57.26  ? 773 ARG A NE    1 
ATOM 5604 C CZ    . ARG A 1 773 ? 95.459  133.048 119.053 1.00 61.91  ? 773 ARG A CZ    1 
ATOM 5605 N NH1   . ARG A 1 773 ? 95.592  133.859 118.015 1.00 64.46  ? 773 ARG A NH1   1 
ATOM 5606 N NH2   . ARG A 1 773 ? 94.238  132.707 119.456 1.00 62.16  ? 773 ARG A NH2   1 
ATOM 5607 N N     . PHE A 1 774 ? 100.403 133.162 123.895 1.00 52.79  ? 774 PHE A N     1 
ATOM 5608 C CA    . PHE A 1 774 ? 101.645 133.594 124.509 1.00 54.85  ? 774 PHE A CA    1 
ATOM 5609 C C     . PHE A 1 774 ? 102.717 133.810 123.448 1.00 52.86  ? 774 PHE A C     1 
ATOM 5610 O O     . PHE A 1 774 ? 102.637 133.297 122.329 1.00 48.49  ? 774 PHE A O     1 
ATOM 5611 C CB    . PHE A 1 774 ? 102.136 132.579 125.539 1.00 51.75  ? 774 PHE A CB    1 
ATOM 5612 C CG    . PHE A 1 774 ? 101.044 131.776 126.179 1.00 55.24  ? 774 PHE A CG    1 
ATOM 5613 C CD1   . PHE A 1 774 ? 100.293 132.320 127.210 1.00 56.00  ? 774 PHE A CD1   1 
ATOM 5614 C CD2   . PHE A 1 774 ? 100.773 130.479 125.763 1.00 57.25  ? 774 PHE A CD2   1 
ATOM 5615 C CE1   . PHE A 1 774 ? 99.296  131.588 127.818 1.00 60.27  ? 774 PHE A CE1   1 
ATOM 5616 C CE2   . PHE A 1 774 ? 99.769  129.747 126.361 1.00 52.89  ? 774 PHE A CE2   1 
ATOM 5617 C CZ    . PHE A 1 774 ? 99.031  130.300 127.389 1.00 57.61  ? 774 PHE A CZ    1 
ATOM 5618 N N     . SER A 1 775 ? 103.724 134.600 123.815 1.00 49.06  ? 775 SER A N     1 
ATOM 5619 C CA    . SER A 1 775 ? 104.805 134.924 122.895 1.00 45.92  ? 775 SER A CA    1 
ATOM 5620 C C     . SER A 1 775 ? 105.691 133.709 122.654 1.00 48.56  ? 775 SER A C     1 
ATOM 5621 O O     . SER A 1 775 ? 105.891 132.875 123.541 1.00 42.57  ? 775 SER A O     1 
ATOM 5622 C CB    . SER A 1 775 ? 105.634 136.085 123.442 1.00 46.74  ? 775 SER A CB    1 
ATOM 5623 O OG    . SER A 1 775 ? 106.288 135.722 124.646 1.00 53.80  ? 775 SER A OG    1 
ATOM 5624 N N     . SER A 1 776 ? 106.220 133.615 121.433 1.00 55.56  ? 776 SER A N     1 
ATOM 5625 C CA    . SER A 1 776 ? 107.002 132.453 121.034 1.00 57.96  ? 776 SER A CA    1 
ATOM 5626 C C     . SER A 1 776 ? 108.394 132.430 121.654 1.00 55.79  ? 776 SER A C     1 
ATOM 5627 O O     . SER A 1 776 ? 109.034 131.370 121.653 1.00 59.45  ? 776 SER A O     1 
ATOM 5628 C CB    . SER A 1 776 ? 107.101 132.395 119.510 1.00 46.83  ? 776 SER A CB    1 
ATOM 5629 O OG    . SER A 1 776 ? 107.419 133.664 118.967 1.00 47.09  ? 776 SER A OG    1 
ATOM 5630 N N     . ASP A 1 777 ? 108.870 133.567 122.174 1.00 37.04  ? 777 ASP A N     1 
ATOM 5631 C CA    . ASP A 1 777 ? 110.121 133.596 122.926 1.00 38.20  ? 777 ASP A CA    1 
ATOM 5632 C C     . ASP A 1 777 ? 110.027 132.744 124.184 1.00 42.48  ? 777 ASP A C     1 
ATOM 5633 O O     . ASP A 1 777 ? 110.957 132.000 124.512 1.00 41.44  ? 777 ASP A O     1 
ATOM 5634 C CB    . ASP A 1 777 ? 110.469 135.036 123.297 1.00 44.61  ? 777 ASP A CB    1 
ATOM 5635 C CG    . ASP A 1 777 ? 111.296 135.727 122.242 1.00 42.61  ? 777 ASP A CG    1 
ATOM 5636 O OD1   . ASP A 1 777 ? 112.440 135.287 122.003 1.00 37.13  ? 777 ASP A OD1   1 
ATOM 5637 O OD2   . ASP A 1 777 ? 110.803 136.712 121.652 1.00 44.09  ? 777 ASP A OD2   1 
ATOM 5638 N N     . GLU A 1 778 ? 108.909 132.845 124.895 1.00 39.45  ? 778 GLU A N     1 
ATOM 5639 C CA    . GLU A 1 778 ? 108.637 131.991 126.041 1.00 38.96  ? 778 GLU A CA    1 
ATOM 5640 C C     . GLU A 1 778 ? 108.393 130.544 125.635 1.00 39.18  ? 778 GLU A C     1 
ATOM 5641 O O     . GLU A 1 778 ? 108.840 129.634 126.345 1.00 41.78  ? 778 GLU A O     1 
ATOM 5642 C CB    . GLU A 1 778 ? 107.436 132.563 126.806 1.00 48.97  ? 778 GLU A CB    1 
ATOM 5643 C CG    . GLU A 1 778 ? 107.049 131.861 128.095 1.00 50.78  ? 778 GLU A CG    1 
ATOM 5644 C CD    . GLU A 1 778 ? 105.843 130.960 127.921 1.00 53.07  ? 778 GLU A CD    1 
ATOM 5645 O OE1   . GLU A 1 778 ? 104.965 131.295 127.101 1.00 49.31  ? 778 GLU A OE1   1 
ATOM 5646 O OE2   . GLU A 1 778 ? 105.761 129.929 128.616 1.00 53.77  ? 778 GLU A OE2   1 
ATOM 5647 N N     . LEU A 1 779 ? 107.719 130.327 124.499 1.00 36.17  ? 779 LEU A N     1 
ATOM 5648 C CA    . LEU A 1 779 ? 107.373 128.982 124.045 1.00 40.60  ? 779 LEU A CA    1 
ATOM 5649 C C     . LEU A 1 779 ? 108.608 128.169 123.685 1.00 31.22  ? 779 LEU A C     1 
ATOM 5650 O O     . LEU A 1 779 ? 108.683 126.982 124.012 1.00 32.69  ? 779 LEU A O     1 
ATOM 5651 C CB    . LEU A 1 779 ? 106.432 129.057 122.843 1.00 37.35  ? 779 LEU A CB    1 
ATOM 5652 C CG    . LEU A 1 779 ? 104.909 128.984 123.015 1.00 41.81  ? 779 LEU A CG    1 
ATOM 5653 C CD1   . LEU A 1 779 ? 104.444 127.549 123.211 1.00 42.14  ? 779 LEU A CD1   1 
ATOM 5654 C CD2   . LEU A 1 779 ? 104.399 129.875 124.149 1.00 41.51  ? 779 LEU A CD2   1 
ATOM 5655 N N     . GLN A 1 780 ? 109.594 128.792 123.035 1.00 30.76  ? 780 GLN A N     1 
ATOM 5656 C CA    . GLN A 1 780 ? 110.774 128.034 122.625 1.00 35.17  ? 780 GLN A CA    1 
ATOM 5657 C C     . GLN A 1 780 ? 111.661 127.660 123.812 1.00 35.01  ? 780 GLN A C     1 
ATOM 5658 O O     . GLN A 1 780 ? 112.202 126.547 123.853 1.00 19.32  ? 780 GLN A O     1 
ATOM 5659 C CB    . GLN A 1 780 ? 111.560 128.808 121.561 1.00 32.82  ? 780 GLN A CB    1 
ATOM 5660 C CG    . GLN A 1 780 ? 112.066 130.169 121.968 1.00 26.62  ? 780 GLN A CG    1 
ATOM 5661 C CD    . GLN A 1 780 ? 113.558 130.221 122.007 1.00 27.10  ? 780 GLN A CD    1 
ATOM 5662 O OE1   . GLN A 1 780 ? 114.226 129.506 121.269 1.00 21.25  ? 780 GLN A OE1   1 
ATOM 5663 N NE2   . GLN A 1 780 ? 114.098 131.048 122.891 1.00 35.93  ? 780 GLN A NE2   1 
ATOM 5664 N N     . ILE A 1 781 ? 111.777 128.534 124.817 1.00 47.07  ? 781 ILE A N     1 
ATOM 5665 C CA    . ILE A 1 781 ? 112.606 128.197 125.969 1.00 39.57  ? 781 ILE A CA    1 
ATOM 5666 C C     . ILE A 1 781 ? 111.873 127.223 126.885 1.00 36.71  ? 781 ILE A C     1 
ATOM 5667 O O     . ILE A 1 781 ? 112.498 126.330 127.465 1.00 46.51  ? 781 ILE A O     1 
ATOM 5668 C CB    . ILE A 1 781 ? 113.092 129.473 126.694 1.00 29.74  ? 781 ILE A CB    1 
ATOM 5669 C CG1   . ILE A 1 781 ? 114.108 129.143 127.800 1.00 29.18  ? 781 ILE A CG1   1 
ATOM 5670 C CG2   . ILE A 1 781 ? 111.941 130.327 127.218 1.00 38.85  ? 781 ILE A CG2   1 
ATOM 5671 C CD1   . ILE A 1 781 ? 115.245 128.241 127.381 1.00 33.37  ? 781 ILE A CD1   1 
ATOM 5672 N N     . LEU A 1 782 ? 110.536 127.321 126.963 1.00 39.52  ? 782 LEU A N     1 
ATOM 5673 C CA    . LEU A 1 782 ? 109.741 126.326 127.684 1.00 40.32  ? 782 LEU A CA    1 
ATOM 5674 C C     . LEU A 1 782 ? 109.846 124.958 127.026 1.00 40.63  ? 782 LEU A C     1 
ATOM 5675 O O     . LEU A 1 782 ? 109.939 123.934 127.712 1.00 30.12  ? 782 LEU A O     1 
ATOM 5676 C CB    . LEU A 1 782 ? 108.281 126.780 127.739 1.00 32.45  ? 782 LEU A CB    1 
ATOM 5677 C CG    . LEU A 1 782 ? 107.168 125.739 127.862 1.00 32.75  ? 782 LEU A CG    1 
ATOM 5678 C CD1   . LEU A 1 782 ? 107.133 125.157 129.261 1.00 36.97  ? 782 LEU A CD1   1 
ATOM 5679 C CD2   . LEU A 1 782 ? 105.829 126.341 127.477 1.00 28.86  ? 782 LEU A CD2   1 
ATOM 5680 N N     . THR A 1 783 ? 109.870 124.933 125.695 1.00 41.78  ? 783 THR A N     1 
ATOM 5681 C CA    . THR A 1 783 ? 109.972 123.686 124.956 1.00 39.45  ? 783 THR A CA    1 
ATOM 5682 C C     . THR A 1 783 ? 111.367 123.081 125.106 1.00 33.08  ? 783 THR A C     1 
ATOM 5683 O O     . THR A 1 783 ? 111.514 121.858 125.235 1.00 38.18  ? 783 THR A O     1 
ATOM 5684 C CB    . THR A 1 783 ? 109.604 123.971 123.499 1.00 34.64  ? 783 THR A CB    1 
ATOM 5685 O OG1   . THR A 1 783 ? 108.195 124.199 123.414 1.00 32.66  ? 783 THR A OG1   1 
ATOM 5686 C CG2   . THR A 1 783 ? 109.896 122.813 122.633 1.00 37.09  ? 783 THR A CG2   1 
ATOM 5687 N N     . TYR A 1 784 ? 112.397 123.930 125.164 1.00 22.89  ? 784 TYR A N     1 
ATOM 5688 C CA    . TYR A 1 784 ? 113.747 123.447 125.446 1.00 37.58  ? 784 TYR A CA    1 
ATOM 5689 C C     . TYR A 1 784 ? 113.865 122.884 126.867 1.00 35.05  ? 784 TYR A C     1 
ATOM 5690 O O     . TYR A 1 784 ? 114.528 121.857 127.088 1.00 28.22  ? 784 TYR A O     1 
ATOM 5691 C CB    . TYR A 1 784 ? 114.749 124.576 125.215 1.00 21.29  ? 784 TYR A CB    1 
ATOM 5692 C CG    . TYR A 1 784 ? 116.167 124.090 125.113 1.00 13.19  ? 784 TYR A CG    1 
ATOM 5693 C CD1   . TYR A 1 784 ? 116.464 122.906 124.458 1.00 24.81  ? 784 TYR A CD1   1 
ATOM 5694 C CD2   . TYR A 1 784 ? 117.209 124.804 125.679 1.00 18.04  ? 784 TYR A CD2   1 
ATOM 5695 C CE1   . TYR A 1 784 ? 117.761 122.449 124.365 1.00 19.33  ? 784 TYR A CE1   1 
ATOM 5696 C CE2   . TYR A 1 784 ? 118.509 124.353 125.588 1.00 26.73  ? 784 TYR A CE2   1 
ATOM 5697 C CZ    . TYR A 1 784 ? 118.776 123.175 124.934 1.00 20.15  ? 784 TYR A CZ    1 
ATOM 5698 O OH    . TYR A 1 784 ? 120.066 122.721 124.842 1.00 27.11  ? 784 TYR A OH    1 
ATOM 5699 N N     . GLN A 1 785 ? 113.201 123.524 127.837 1.00 30.60  ? 785 GLN A N     1 
ATOM 5700 C CA    . GLN A 1 785 ? 113.161 122.977 129.192 1.00 25.41  ? 785 GLN A CA    1 
ATOM 5701 C C     . GLN A 1 785 ? 112.443 121.633 129.216 1.00 36.98  ? 785 GLN A C     1 
ATOM 5702 O O     . GLN A 1 785 ? 112.942 120.667 129.801 1.00 51.33  ? 785 GLN A O     1 
ATOM 5703 C CB    . GLN A 1 785 ? 112.482 123.951 130.158 1.00 31.44  ? 785 GLN A CB    1 
ATOM 5704 C CG    . GLN A 1 785 ? 113.206 125.260 130.394 1.00 28.74  ? 785 GLN A CG    1 
ATOM 5705 C CD    . GLN A 1 785 ? 113.519 125.512 131.841 1.00 34.20  ? 785 GLN A CD    1 
ATOM 5706 O OE1   . GLN A 1 785 ? 113.891 124.602 132.571 1.00 40.30  ? 785 GLN A OE1   1 
ATOM 5707 N NE2   . GLN A 1 785 ? 113.386 126.757 132.265 1.00 42.69  ? 785 GLN A NE2   1 
ATOM 5708 N N     . LEU A 1 786 ? 111.310 121.540 128.511 1.00 35.04  ? 786 LEU A N     1 
ATOM 5709 C CA    . LEU A 1 786 ? 110.512 120.317 128.485 1.00 29.70  ? 786 LEU A CA    1 
ATOM 5710 C C     . LEU A 1 786 ? 111.236 119.182 127.783 1.00 30.55  ? 786 LEU A C     1 
ATOM 5711 O O     . LEU A 1 786 ? 110.991 118.009 128.078 1.00 28.56  ? 786 LEU A O     1 
ATOM 5712 C CB    . LEU A 1 786 ? 109.180 120.583 127.800 1.00 25.83  ? 786 LEU A CB    1 
ATOM 5713 C CG    . LEU A 1 786 ? 107.999 120.840 128.716 1.00 26.36  ? 786 LEU A CG    1 
ATOM 5714 C CD1   . LEU A 1 786 ? 106.750 120.838 127.885 1.00 27.66  ? 786 LEU A CD1   1 
ATOM 5715 C CD2   . LEU A 1 786 ? 107.928 119.786 129.800 1.00 31.45  ? 786 LEU A CD2   1 
ATOM 5716 N N     . CYS A 1 787 ? 112.119 119.515 126.838 1.00 36.37  ? 787 CYS A N     1 
ATOM 5717 C CA    . CYS A 1 787 ? 113.119 118.554 126.392 1.00 26.74  ? 787 CYS A CA    1 
ATOM 5718 C C     . CYS A 1 787 ? 114.003 118.148 127.556 1.00 33.09  ? 787 CYS A C     1 
ATOM 5719 O O     . CYS A 1 787 ? 114.329 116.969 127.718 1.00 24.02  ? 787 CYS A O     1 
ATOM 5720 C CB    . CYS A 1 787 ? 113.976 119.135 125.268 1.00 30.51  ? 787 CYS A CB    1 
ATOM 5721 S SG    . CYS A 1 787 ? 113.134 119.450 123.719 1.00 35.97  ? 787 CYS A SG    1 
ATOM 5722 N N     . HIS A 1 788 ? 114.389 119.107 128.394 1.00 42.40  ? 788 HIS A N     1 
ATOM 5723 C CA    . HIS A 1 788 ? 115.102 118.715 129.612 1.00 40.26  ? 788 HIS A CA    1 
ATOM 5724 C C     . HIS A 1 788 ? 114.167 118.511 130.807 1.00 37.78  ? 788 HIS A C     1 
ATOM 5725 O O     . HIS A 1 788 ? 114.475 118.907 131.929 1.00 36.55  ? 788 HIS A O     1 
ATOM 5726 C CB    . HIS A 1 788 ? 116.174 119.747 129.930 1.00 32.23  ? 788 HIS A CB    1 
ATOM 5727 C CG    . HIS A 1 788 ? 117.104 120.018 128.791 1.00 32.27  ? 788 HIS A CG    1 
ATOM 5728 N ND1   . HIS A 1 788 ? 117.904 119.044 128.234 1.00 45.23  ? 788 HIS A ND1   1 
ATOM 5729 C CD2   . HIS A 1 788 ? 117.382 121.159 128.119 1.00 29.47  ? 788 HIS A CD2   1 
ATOM 5730 C CE1   . HIS A 1 788 ? 118.620 119.567 127.256 1.00 38.98  ? 788 HIS A CE1   1 
ATOM 5731 N NE2   . HIS A 1 788 ? 118.325 120.851 127.169 1.00 38.64  ? 788 HIS A NE2   1 
ATOM 5732 N N     . THR A 1 789 ? 113.024 117.847 130.577 1.00 22.46  ? 789 THR A N     1 
ATOM 5733 C CA    . THR A 1 789 ? 112.251 117.173 131.623 1.00 26.49  ? 789 THR A CA    1 
ATOM 5734 C C     . THR A 1 789 ? 111.879 115.751 131.233 1.00 32.93  ? 789 THR A C     1 
ATOM 5735 O O     . THR A 1 789 ? 110.793 115.290 131.598 1.00 35.23  ? 789 THR A O     1 
ATOM 5736 C CB    . THR A 1 789 ? 110.940 117.885 132.019 1.00 35.42  ? 789 THR A CB    1 
ATOM 5737 O OG1   . THR A 1 789 ? 109.870 117.448 131.169 1.00 30.34  ? 789 THR A OG1   1 
ATOM 5738 C CG2   . THR A 1 789 ? 111.026 119.384 132.068 1.00 38.85  ? 789 THR A CG2   1 
ATOM 5739 N N     . TYR A 1 790 ? 112.731 115.043 130.501 1.00 42.33  ? 790 TYR A N     1 
ATOM 5740 C CA    . TYR A 1 790 ? 112.476 113.632 130.259 1.00 45.71  ? 790 TYR A CA    1 
ATOM 5741 C C     . TYR A 1 790 ? 112.772 112.836 131.521 1.00 48.03  ? 790 TYR A C     1 
ATOM 5742 O O     . TYR A 1 790 ? 113.333 113.356 132.488 1.00 51.47  ? 790 TYR A O     1 
ATOM 5743 C CB    . TYR A 1 790 ? 113.327 113.120 129.100 1.00 39.51  ? 790 TYR A CB    1 
ATOM 5744 C CG    . TYR A 1 790 ? 112.762 111.889 128.431 1.00 40.19  ? 790 TYR A CG    1 
ATOM 5745 C CD1   . TYR A 1 790 ? 111.515 111.915 127.843 1.00 37.94  ? 790 TYR A CD1   1 
ATOM 5746 C CD2   . TYR A 1 790 ? 113.466 110.697 128.415 1.00 50.82  ? 790 TYR A CD2   1 
ATOM 5747 C CE1   . TYR A 1 790 ? 110.991 110.798 127.252 1.00 46.56  ? 790 TYR A CE1   1 
ATOM 5748 C CE2   . TYR A 1 790 ? 112.958 109.575 127.811 1.00 51.12  ? 790 TYR A CE2   1 
ATOM 5749 C CZ    . TYR A 1 790 ? 111.719 109.628 127.231 1.00 45.21  ? 790 TYR A CZ    1 
ATOM 5750 O OH    . TYR A 1 790 ? 111.207 108.502 126.633 1.00 45.02  ? 790 TYR A OH    1 
ATOM 5751 N N     . VAL A 1 791 ? 112.346 111.574 131.533 1.00 35.83  ? 791 VAL A N     1 
ATOM 5752 C CA    . VAL A 1 791 ? 112.853 110.663 132.548 1.00 34.60  ? 791 VAL A CA    1 
ATOM 5753 C C     . VAL A 1 791 ? 114.345 110.459 132.343 1.00 47.59  ? 791 VAL A C     1 
ATOM 5754 O O     . VAL A 1 791 ? 115.165 110.977 133.108 1.00 50.02  ? 791 VAL A O     1 
ATOM 5755 C CB    . VAL A 1 791 ? 112.088 109.335 132.511 1.00 41.96  ? 791 VAL A CB    1 
ATOM 5756 C CG1   . VAL A 1 791 ? 112.707 108.365 133.477 1.00 48.96  ? 791 VAL A CG1   1 
ATOM 5757 C CG2   . VAL A 1 791 ? 110.647 109.574 132.839 1.00 50.30  ? 791 VAL A CG2   1 
ATOM 5758 N N     . ARG A 1 792 ? 114.721 109.826 131.231 1.00 54.16  ? 792 ARG A N     1 
ATOM 5759 C CA    . ARG A 1 792 ? 116.102 109.860 130.744 1.00 58.16  ? 792 ARG A CA    1 
ATOM 5760 C C     . ARG A 1 792 ? 116.439 111.216 130.130 1.00 40.79  ? 792 ARG A C     1 
ATOM 5761 O O     . ARG A 1 792 ? 116.540 111.386 128.916 1.00 33.51  ? 792 ARG A O     1 
ATOM 5762 C CB    . ARG A 1 792 ? 116.358 108.751 129.738 1.00 53.59  ? 792 ARG A CB    1 
ATOM 5763 C CG    . ARG A 1 792 ? 117.375 107.809 130.247 1.00 45.32  ? 792 ARG A CG    1 
ATOM 5764 C CD    . ARG A 1 792 ? 118.752 108.431 130.038 1.00 36.18  ? 792 ARG A CD    1 
ATOM 5765 N NE    . ARG A 1 792 ? 118.911 108.887 128.667 1.00 45.90  ? 792 ARG A NE    1 
ATOM 5766 C CZ    . ARG A 1 792 ? 119.357 108.119 127.684 1.00 57.26  ? 792 ARG A CZ    1 
ATOM 5767 N NH1   . ARG A 1 792 ? 119.991 106.984 127.929 1.00 62.02  ? 792 ARG A NH1   1 
ATOM 5768 N NH2   . ARG A 1 792 ? 119.168 108.500 126.423 1.00 51.44  ? 792 ARG A NH2   1 
ATOM 5769 N N     . CYS A 1 793 ? 116.638 112.182 131.012 1.00 26.81  ? 793 CYS A N     1 
ATOM 5770 C CA    . CYS A 1 793 ? 117.146 113.487 130.644 1.00 38.19  ? 793 CYS A CA    1 
ATOM 5771 C C     . CYS A 1 793 ? 118.661 113.556 130.772 1.00 48.02  ? 793 CYS A C     1 
ATOM 5772 O O     . CYS A 1 793 ? 119.248 114.618 130.544 1.00 53.21  ? 793 CYS A O     1 
ATOM 5773 C CB    . CYS A 1 793 ? 116.476 114.552 131.509 1.00 47.70  ? 793 CYS A CB    1 
ATOM 5774 S SG    . CYS A 1 793 ? 116.378 114.141 133.270 1.00 48.75  ? 793 CYS A SG    1 
ATOM 5775 N N     . THR A 1 794 ? 119.288 112.431 131.123 1.00 43.34  ? 794 THR A N     1 
ATOM 5776 C CA    . THR A 1 794 ? 120.737 112.305 131.192 1.00 46.07  ? 794 THR A CA    1 
ATOM 5777 C C     . THR A 1 794 ? 121.382 112.451 129.812 1.00 47.01  ? 794 THR A C     1 
ATOM 5778 O O     . THR A 1 794 ? 122.491 112.986 129.698 1.00 44.83  ? 794 THR A O     1 
ATOM 5779 C CB    . THR A 1 794 ? 121.058 110.948 131.852 1.00 45.21  ? 794 THR A CB    1 
ATOM 5780 O OG1   . THR A 1 794 ? 120.524 110.937 133.180 1.00 37.86  ? 794 THR A OG1   1 
ATOM 5781 C CG2   . THR A 1 794 ? 122.551 110.696 131.972 1.00 48.63  ? 794 THR A CG2   1 
ATOM 5782 N N     . ARG A 1 795 ? 120.684 112.056 128.758 1.00 51.81  ? 795 ARG A N     1 
ATOM 5783 C CA    . ARG A 1 795 ? 121.115 112.284 127.391 1.00 50.19  ? 795 ARG A CA    1 
ATOM 5784 C C     . ARG A 1 795 ? 120.031 113.120 126.723 1.00 49.94  ? 795 ARG A C     1 
ATOM 5785 O O     . ARG A 1 795 ? 118.862 113.053 127.108 1.00 56.20  ? 795 ARG A O     1 
ATOM 5786 C CB    . ARG A 1 795 ? 121.368 110.936 126.688 1.00 48.18  ? 795 ARG A CB    1 
ATOM 5787 C CG    . ARG A 1 795 ? 121.493 110.904 125.171 1.00 50.65  ? 795 ARG A CG    1 
ATOM 5788 C CD    . ARG A 1 795 ? 122.685 111.688 124.666 1.00 50.20  ? 795 ARG A CD    1 
ATOM 5789 N NE    . ARG A 1 795 ? 122.610 111.865 123.222 1.00 50.30  ? 795 ARG A NE    1 
ATOM 5790 C CZ    . ARG A 1 795 ? 122.772 113.024 122.602 1.00 53.37  ? 795 ARG A CZ    1 
ATOM 5791 N NH1   . ARG A 1 795 ? 123.098 114.119 123.261 1.00 51.34  ? 795 ARG A NH1   1 
ATOM 5792 N NH2   . ARG A 1 795 ? 122.587 113.091 121.289 1.00 55.24  ? 795 ARG A NH2   1 
ATOM 5793 N N     . SER A 1 796 ? 120.444 113.971 125.783 1.00 45.19  ? 796 SER A N     1 
ATOM 5794 C CA    . SER A 1 796 ? 119.542 114.921 125.140 1.00 44.54  ? 796 SER A CA    1 
ATOM 5795 C C     . SER A 1 796 ? 118.480 114.200 124.330 1.00 43.62  ? 796 SER A C     1 
ATOM 5796 O O     . SER A 1 796 ? 118.790 113.494 123.368 1.00 42.80  ? 796 SER A O     1 
ATOM 5797 C CB    . SER A 1 796 ? 120.338 115.855 124.234 1.00 53.90  ? 796 SER A CB    1 
ATOM 5798 O OG    . SER A 1 796 ? 120.621 115.237 122.991 1.00 40.78  ? 796 SER A OG    1 
ATOM 5799 N N     . VAL A 1 797 ? 117.225 114.403 124.715 1.00 53.63  ? 797 VAL A N     1 
ATOM 5800 C CA    . VAL A 1 797 ? 116.158 113.530 124.252 1.00 48.42  ? 797 VAL A CA    1 
ATOM 5801 C C     . VAL A 1 797 ? 115.425 114.149 123.066 1.00 42.99  ? 797 VAL A C     1 
ATOM 5802 O O     . VAL A 1 797 ? 114.536 113.515 122.485 1.00 48.87  ? 797 VAL A O     1 
ATOM 5803 C CB    . VAL A 1 797 ? 115.207 113.231 125.425 1.00 45.42  ? 797 VAL A CB    1 
ATOM 5804 C CG1   . VAL A 1 797 ? 114.291 114.403 125.690 1.00 46.60  ? 797 VAL A CG1   1 
ATOM 5805 C CG2   . VAL A 1 797 ? 114.464 111.921 125.250 1.00 45.53  ? 797 VAL A CG2   1 
ATOM 5806 N N     . SER A 1 798 ? 115.737 115.408 122.749 1.00 27.85  ? 798 SER A N     1 
ATOM 5807 C CA    . SER A 1 798 ? 115.466 116.090 121.481 1.00 37.28  ? 798 SER A CA    1 
ATOM 5808 C C     . SER A 1 798 ? 114.020 116.422 121.201 1.00 37.76  ? 798 SER A C     1 
ATOM 5809 O O     . SER A 1 798 ? 113.729 117.118 120.225 1.00 37.23  ? 798 SER A O     1 
ATOM 5810 C CB    . SER A 1 798 ? 115.925 115.285 120.280 1.00 42.06  ? 798 SER A CB    1 
ATOM 5811 O OG    . SER A 1 798 ? 114.828 114.581 119.724 1.00 33.08  ? 798 SER A OG    1 
ATOM 5812 N N     . ILE A 1 799 ? 113.111 115.912 122.012 1.00 38.33  ? 799 ILE A N     1 
ATOM 5813 C CA    . ILE A 1 799 ? 111.693 115.961 121.712 1.00 30.88  ? 799 ILE A CA    1 
ATOM 5814 C C     . ILE A 1 799 ? 111.138 115.990 123.124 1.00 29.02  ? 799 ILE A C     1 
ATOM 5815 O O     . ILE A 1 799 ? 111.602 115.192 123.950 1.00 38.19  ? 799 ILE A O     1 
ATOM 5816 C CB    . ILE A 1 799 ? 111.237 114.722 120.930 1.00 36.70  ? 799 ILE A CB    1 
ATOM 5817 C CG1   . ILE A 1 799 ? 111.439 114.947 119.436 1.00 32.89  ? 799 ILE A CG1   1 
ATOM 5818 C CG2   . ILE A 1 799 ? 109.787 114.386 121.240 1.00 34.03  ? 799 ILE A CG2   1 
ATOM 5819 C CD1   . ILE A 1 799 ? 110.485 115.801 118.833 1.00 29.79  ? 799 ILE A CD1   1 
ATOM 5820 N N     . PRO A 1 800 ? 110.238 116.904 123.470 1.00 16.43  ? 800 PRO A N     1 
ATOM 5821 C CA    . PRO A 1 800 ? 109.839 117.044 124.871 1.00 28.18  ? 800 PRO A CA    1 
ATOM 5822 C C     . PRO A 1 800 ? 109.062 115.833 125.364 1.00 31.57  ? 800 PRO A C     1 
ATOM 5823 O O     . PRO A 1 800 ? 108.443 115.115 124.579 1.00 44.72  ? 800 PRO A O     1 
ATOM 5824 C CB    . PRO A 1 800 ? 108.983 118.307 124.859 1.00 19.91  ? 800 PRO A CB    1 
ATOM 5825 C CG    . PRO A 1 800 ? 109.527 119.081 123.732 1.00 25.96  ? 800 PRO A CG    1 
ATOM 5826 C CD    . PRO A 1 800 ? 109.777 118.047 122.675 1.00 24.22  ? 800 PRO A CD    1 
ATOM 5827 N N     . ALA A 1 801 ? 109.136 115.623 126.678 1.00 8.73   ? 801 ALA A N     1 
ATOM 5828 C CA    . ALA A 1 801 ? 108.893 114.320 127.297 1.00 0.00   ? 801 ALA A CA    1 
ATOM 5829 C C     . ALA A 1 801 ? 107.537 113.654 127.039 1.00 17.71  ? 801 ALA A C     1 
ATOM 5830 O O     . ALA A 1 801 ? 107.543 112.428 126.815 1.00 43.59  ? 801 ALA A O     1 
ATOM 5831 C CB    . ALA A 1 801 ? 109.151 114.439 128.807 1.00 23.83  ? 801 ALA A CB    1 
ATOM 5832 N N     . PRO A 1 802 ? 106.365 114.340 127.058 1.00 7.36   ? 802 PRO A N     1 
ATOM 5833 C CA    . PRO A 1 802 ? 105.119 113.588 126.816 1.00 20.79  ? 802 PRO A CA    1 
ATOM 5834 C C     . PRO A 1 802 ? 104.944 113.037 125.408 1.00 26.89  ? 802 PRO A C     1 
ATOM 5835 O O     . PRO A 1 802 ? 104.207 112.061 125.241 1.00 31.69  ? 802 PRO A O     1 
ATOM 5836 C CB    . PRO A 1 802 ? 104.029 114.601 127.163 1.00 12.03  ? 802 PRO A CB    1 
ATOM 5837 C CG    . PRO A 1 802 ? 104.649 115.872 127.121 1.00 17.71  ? 802 PRO A CG    1 
ATOM 5838 C CD    . PRO A 1 802 ? 106.030 115.698 127.534 1.00 12.73  ? 802 PRO A CD    1 
ATOM 5839 N N     . ALA A 1 803 ? 105.646 113.575 124.409 1.00 21.35  ? 803 ALA A N     1 
ATOM 5840 C CA    . ALA A 1 803 ? 105.586 112.981 123.077 1.00 15.69  ? 803 ALA A CA    1 
ATOM 5841 C C     . ALA A 1 803 ? 106.287 111.630 123.037 1.00 11.92  ? 803 ALA A C     1 
ATOM 5842 O O     . ALA A 1 803 ? 105.784 110.677 122.430 1.00 30.12  ? 803 ALA A O     1 
ATOM 5843 C CB    . ALA A 1 803 ? 106.194 113.928 122.050 1.00 15.59  ? 803 ALA A CB    1 
ATOM 5844 N N     . TYR A 1 804 ? 107.427 111.514 123.711 1.00 3.51   ? 804 TYR A N     1 
ATOM 5845 C CA    . TYR A 1 804 ? 108.136 110.242 123.703 1.00 11.01  ? 804 TYR A CA    1 
ATOM 5846 C C     . TYR A 1 804 ? 107.485 109.225 124.636 1.00 25.17  ? 804 TYR A C     1 
ATOM 5847 O O     . TYR A 1 804 ? 107.503 108.016 124.348 1.00 25.02  ? 804 TYR A O     1 
ATOM 5848 C CB    . TYR A 1 804 ? 109.598 110.467 124.054 1.00 10.92  ? 804 TYR A CB    1 
ATOM 5849 C CG    . TYR A 1 804 ? 110.483 110.642 122.851 1.00 22.80  ? 804 TYR A CG    1 
ATOM 5850 C CD1   . TYR A 1 804 ? 109.939 110.781 121.581 1.00 34.17  ? 804 TYR A CD1   1 
ATOM 5851 C CD2   . TYR A 1 804 ? 111.859 110.683 122.983 1.00 29.07  ? 804 TYR A CD2   1 
ATOM 5852 C CE1   . TYR A 1 804 ? 110.738 110.944 120.479 1.00 35.21  ? 804 TYR A CE1   1 
ATOM 5853 C CE2   . TYR A 1 804 ? 112.668 110.849 121.887 1.00 31.95  ? 804 TYR A CE2   1 
ATOM 5854 C CZ    . TYR A 1 804 ? 112.101 110.978 120.638 1.00 28.61  ? 804 TYR A CZ    1 
ATOM 5855 O OH    . TYR A 1 804 ? 112.900 111.143 119.532 1.00 31.51  ? 804 TYR A OH    1 
ATOM 5856 N N     . TYR A 1 805 ? 106.889 109.691 125.744 1.00 22.47  ? 805 TYR A N     1 
ATOM 5857 C CA    . TYR A 1 805 ? 106.036 108.810 126.543 1.00 18.40  ? 805 TYR A CA    1 
ATOM 5858 C C     . TYR A 1 805 ? 104.855 108.302 125.733 1.00 27.25  ? 805 TYR A C     1 
ATOM 5859 O O     . TYR A 1 805 ? 104.469 107.132 125.849 1.00 35.95  ? 805 TYR A O     1 
ATOM 5860 C CB    . TYR A 1 805 ? 105.494 109.517 127.779 1.00 5.35   ? 805 TYR A CB    1 
ATOM 5861 C CG    . TYR A 1 805 ? 106.480 110.152 128.710 1.00 10.41  ? 805 TYR A CG    1 
ATOM 5862 C CD1   . TYR A 1 805 ? 107.750 109.624 128.907 1.00 13.07  ? 805 TYR A CD1   1 
ATOM 5863 C CD2   . TYR A 1 805 ? 106.118 111.270 129.427 1.00 19.66  ? 805 TYR A CD2   1 
ATOM 5864 C CE1   . TYR A 1 805 ? 108.633 110.225 129.789 1.00 22.80  ? 805 TYR A CE1   1 
ATOM 5865 C CE2   . TYR A 1 805 ? 106.982 111.871 130.284 1.00 17.22  ? 805 TYR A CE2   1 
ATOM 5866 C CZ    . TYR A 1 805 ? 108.230 111.355 130.472 1.00 26.06  ? 805 TYR A CZ    1 
ATOM 5867 O OH    . TYR A 1 805 ? 109.056 112.003 131.353 1.00 31.38  ? 805 TYR A OH    1 
ATOM 5868 N N     . ALA A 1 806 ? 104.277 109.176 124.905 1.00 29.43  ? 806 ALA A N     1 
ATOM 5869 C CA    . ALA A 1 806 ? 103.164 108.800 124.048 1.00 30.70  ? 806 ALA A CA    1 
ATOM 5870 C C     . ALA A 1 806 ? 103.579 107.762 123.020 1.00 29.75  ? 806 ALA A C     1 
ATOM 5871 O O     . ALA A 1 806 ? 102.814 106.850 122.712 1.00 26.78  ? 806 ALA A O     1 
ATOM 5872 C CB    . ALA A 1 806 ? 102.613 110.041 123.365 1.00 29.15  ? 806 ALA A CB    1 
ATOM 5873 N N     . HIS A 1 807 ? 104.806 107.873 122.504 1.00 41.26  ? 807 HIS A N     1 
ATOM 5874 C CA    . HIS A 1 807 ? 105.315 106.846 121.553 1.00 24.28  ? 807 HIS A CA    1 
ATOM 5875 C C     . HIS A 1 807 ? 105.384 105.494 122.272 1.00 31.48  ? 807 HIS A C     1 
ATOM 5876 O O     . HIS A 1 807 ? 104.938 104.455 121.712 1.00 44.25  ? 807 HIS A O     1 
ATOM 5877 C CB    . HIS A 1 807 ? 106.682 107.259 120.998 1.00 32.24  ? 807 HIS A CB    1 
ATOM 5878 C CG    . HIS A 1 807 ? 106.696 107.478 119.522 1.00 36.67  ? 807 HIS A CG    1 
ATOM 5879 N ND1   . HIS A 1 807 ? 105.970 106.702 118.644 1.00 46.77  ? 807 HIS A ND1   1 
ATOM 5880 C CD2   . HIS A 1 807 ? 107.340 108.381 118.773 1.00 39.07  ? 807 HIS A CD2   1 
ATOM 5881 C CE1   . HIS A 1 807 ? 106.179 107.130 117.407 1.00 47.22  ? 807 HIS A CE1   1 
ATOM 5882 N NE2   . HIS A 1 807 ? 107.007 108.150 117.463 1.00 42.40  ? 807 HIS A NE2   1 
ATOM 5883 N N     . LEU A 1 808 ? 105.934 105.503 123.490 1.00 30.57  ? 808 LEU A N     1 
ATOM 5884 C CA    . LEU A 1 808 ? 106.043 104.251 124.284 1.00 39.05  ? 808 LEU A CA    1 
ATOM 5885 C C     . LEU A 1 808 ? 104.634 103.693 124.534 1.00 27.01  ? 808 LEU A C     1 
ATOM 5886 O O     . LEU A 1 808 ? 104.418 102.492 124.274 1.00 14.95  ? 808 LEU A O     1 
ATOM 5887 C CB    . LEU A 1 808 ? 106.772 104.539 125.594 1.00 35.47  ? 808 LEU A CB    1 
ATOM 5888 C CG    . LEU A 1 808 ? 108.203 105.072 125.470 1.00 12.47  ? 808 LEU A CG    1 
ATOM 5889 C CD1   . LEU A 1 808 ? 108.613 105.817 126.729 1.00 4.97   ? 808 LEU A CD1   1 
ATOM 5890 C CD2   . LEU A 1 808 ? 109.177 103.946 125.172 1.00 19.14  ? 808 LEU A CD2   1 
ATOM 5891 N N     . VAL A 1 809 ? 103.713 104.537 125.009 1.00 27.88  ? 809 VAL A N     1 
ATOM 5892 C CA    . VAL A 1 809 ? 102.334 104.061 125.334 1.00 33.86  ? 809 VAL A CA    1 
ATOM 5893 C C     . VAL A 1 809 ? 101.611 103.699 124.024 1.00 34.42  ? 809 VAL A C     1 
ATOM 5894 O O     . VAL A 1 809 ? 100.701 102.847 124.073 1.00 41.42  ? 809 VAL A O     1 
ATOM 5895 C CB    . VAL A 1 809 ? 101.535 105.078 126.174 1.00 32.00  ? 809 VAL A CB    1 
ATOM 5896 C CG1   . VAL A 1 809 ? 101.010 106.238 125.340 1.00 27.91  ? 809 VAL A CG1   1 
ATOM 5897 C CG2   . VAL A 1 809 ? 100.401 104.408 126.936 1.00 33.28  ? 809 VAL A CG2   1 
ATOM 5898 N N     . ALA A 1 810 ? 101.998 104.311 122.902 1.00 26.07  ? 810 ALA A N     1 
ATOM 5899 C CA    . ALA A 1 810 ? 101.405 103.931 121.597 1.00 20.27  ? 810 ALA A CA    1 
ATOM 5900 C C     . ALA A 1 810 ? 101.809 102.493 121.272 1.00 24.40  ? 810 ALA A C     1 
ATOM 5901 O O     . ALA A 1 810 ? 100.929 101.674 120.929 1.00 38.79  ? 810 ALA A O     1 
ATOM 5902 C CB    . ALA A 1 810 ? 101.851 104.886 120.514 1.00 42.84  ? 810 ALA A CB    1 
ATOM 5903 N N     . PHE A 1 811 ? 103.104 102.191 121.393 1.00 23.05  ? 811 PHE A N     1 
ATOM 5904 C CA    . PHE A 1 811 ? 103.580 100.801 121.150 1.00 27.89  ? 811 PHE A CA    1 
ATOM 5905 C C     . PHE A 1 811 ? 102.899 99.868  122.165 1.00 30.75  ? 811 PHE A C     1 
ATOM 5906 O O     . PHE A 1 811 ? 102.618 98.685  121.835 1.00 36.21  ? 811 PHE A O     1 
ATOM 5907 C CB    . PHE A 1 811 ? 105.112 100.869 121.162 1.00 31.58  ? 811 PHE A CB    1 
ATOM 5908 C CG    . PHE A 1 811 ? 105.871 99.867  122.021 1.00 23.16  ? 811 PHE A CG    1 
ATOM 5909 C CD1   . PHE A 1 811 ? 106.412 100.243 123.245 1.00 25.38  ? 811 PHE A CD1   1 
ATOM 5910 C CD2   . PHE A 1 811 ? 106.085 98.565  121.581 1.00 29.24  ? 811 PHE A CD2   1 
ATOM 5911 C CE1   . PHE A 1 811 ? 107.121 99.337  124.017 1.00 32.88  ? 811 PHE A CE1   1 
ATOM 5912 C CE2   . PHE A 1 811 ? 106.794 97.663  122.358 1.00 39.39  ? 811 PHE A CE2   1 
ATOM 5913 C CZ    . PHE A 1 811 ? 107.310 98.050  123.573 1.00 39.71  ? 811 PHE A CZ    1 
ATOM 5914 N N     . ARG A 1 812 ? 102.603 100.394 123.360 1.00 28.43  ? 812 ARG A N     1 
ATOM 5915 C CA    . ARG A 1 812 ? 101.936 99.578  124.410 1.00 24.08  ? 812 ARG A CA    1 
ATOM 5916 C C     . ARG A 1 812 ? 100.527 99.193  123.934 1.00 26.63  ? 812 ARG A C     1 
ATOM 5917 O O     . ARG A 1 812 ? 100.195 97.992  124.010 1.00 28.67  ? 812 ARG A O     1 
ATOM 5918 C CB    . ARG A 1 812 ? 101.922 100.337 125.741 1.00 33.42  ? 812 ARG A CB    1 
ATOM 5919 C CG    . ARG A 1 812 ? 103.299 100.326 126.387 1.00 42.77  ? 812 ARG A CG    1 
ATOM 5920 C CD    . ARG A 1 812 ? 103.720 98.910  126.744 1.00 31.42  ? 812 ARG A CD    1 
ATOM 5921 N NE    . ARG A 1 812 ? 104.672 98.296  125.812 1.00 22.25  ? 812 ARG A NE    1 
ATOM 5922 C CZ    . ARG A 1 812 ? 104.422 97.214  125.086 1.00 31.38  ? 812 ARG A CZ    1 
ATOM 5923 N NH1   . ARG A 1 812 ? 104.556 96.011  125.612 1.00 38.08  ? 812 ARG A NH1   1 
ATOM 5924 N NH2   . ARG A 1 812 ? 104.039 97.337  123.830 1.00 32.95  ? 812 ARG A NH2   1 
ATOM 5925 N N     . ALA A 1 813 ? 99.741  100.167 123.464 1.00 31.34  ? 813 ALA A N     1 
ATOM 5926 C CA    . ALA A 1 813 ? 98.389  99.878  122.929 1.00 24.62  ? 813 ALA A CA    1 
ATOM 5927 C C     . ALA A 1 813 ? 98.518  98.927  121.740 1.00 25.77  ? 813 ALA A C     1 
ATOM 5928 O O     . ALA A 1 813 ? 97.629  98.065  121.562 1.00 28.93  ? 813 ALA A O     1 
ATOM 5929 C CB    . ALA A 1 813 ? 97.704  101.166 122.533 1.00 33.37  ? 813 ALA A CB    1 
ATOM 5930 N N     . ARG A 1 814 ? 99.587  99.082  120.953 1.00 40.68  ? 814 ARG A N     1 
ATOM 5931 C CA    . ARG A 1 814 ? 99.824  98.192  119.786 1.00 44.91  ? 814 ARG A CA    1 
ATOM 5932 C C     . ARG A 1 814 ? 99.918  96.739  120.275 1.00 44.83  ? 814 ARG A C     1 
ATOM 5933 O O     . ARG A 1 814 ? 99.193  95.880  119.725 1.00 47.73  ? 814 ARG A O     1 
ATOM 5934 C CB    . ARG A 1 814 ? 101.102 98.612  119.051 1.00 42.99  ? 814 ARG A CB    1 
ATOM 5935 C CG    . ARG A 1 814 ? 101.781 97.507  118.256 1.00 40.30  ? 814 ARG A CG    1 
ATOM 5936 C CD    . ARG A 1 814 ? 101.344 97.502  116.801 1.00 39.98  ? 814 ARG A CD    1 
ATOM 5937 N NE    . ARG A 1 814 ? 101.897 98.637  116.055 1.00 42.95  ? 814 ARG A NE    1 
ATOM 5938 C CZ    . ARG A 1 814 ? 103.138 98.700  115.593 1.00 46.28  ? 814 ARG A CZ    1 
ATOM 5939 N NH1   . ARG A 1 814 ? 103.504 97.940  114.576 1.00 42.98  ? 814 ARG A NH1   1 
ATOM 5940 N NH2   . ARG A 1 814 ? 104.011 99.520  116.150 1.00 45.93  ? 814 ARG A NH2   1 
ATOM 5941 N N     . TYR A 1 815 ? 100.767 96.482  121.275 1.00 40.81  ? 815 TYR A N     1 
ATOM 5942 C CA    . TYR A 1 815 ? 100.964 95.088  121.764 1.00 43.13  ? 815 TYR A CA    1 
ATOM 5943 C C     . TYR A 1 815 ? 99.719  94.616  122.520 1.00 43.13  ? 815 TYR A C     1 
ATOM 5944 O O     . TYR A 1 815 ? 99.510  93.386  122.624 1.00 34.70  ? 815 TYR A O     1 
ATOM 5945 C CB    . TYR A 1 815 ? 102.216 94.996  122.641 1.00 37.75  ? 815 TYR A CB    1 
ATOM 5946 C CG    . TYR A 1 815 ? 103.517 94.941  121.852 1.00 32.45  ? 815 TYR A CG    1 
ATOM 5947 C CD1   . TYR A 1 815 ? 103.655 95.633  120.656 1.00 35.23  ? 815 TYR A CD1   1 
ATOM 5948 C CD2   . TYR A 1 815 ? 104.602 94.199  122.302 1.00 37.92  ? 815 TYR A CD2   1 
ATOM 5949 C CE1   . TYR A 1 815 ? 104.831 95.591  119.928 1.00 39.60  ? 815 TYR A CE1   1 
ATOM 5950 C CE2   . TYR A 1 815 ? 105.784 94.148  121.583 1.00 37.79  ? 815 TYR A CE2   1 
ATOM 5951 C CZ    . TYR A 1 815 ? 105.899 94.846  120.394 1.00 39.57  ? 815 TYR A CZ    1 
ATOM 5952 O OH    . TYR A 1 815 ? 107.056 94.808  119.672 1.00 43.72  ? 815 TYR A OH    1 
ATOM 5953 N N     . HIS A 1 816 ? 98.932  95.555  123.055 1.00 49.55  ? 816 HIS A N     1 
ATOM 5954 C CA    . HIS A 1 816 ? 97.755  95.183  123.889 1.00 49.49  ? 816 HIS A CA    1 
ATOM 5955 C C     . HIS A 1 816 ? 96.764  94.333  123.084 1.00 44.58  ? 816 HIS A C     1 
ATOM 5956 O O     . HIS A 1 816 ? 95.837  93.761  123.697 1.00 44.82  ? 816 HIS A O     1 
ATOM 5957 C CB    . HIS A 1 816 ? 97.082  96.437  124.459 1.00 43.30  ? 816 HIS A CB    1 
ATOM 5958 C CG    . HIS A 1 816 ? 97.794  97.017  125.635 1.00 32.51  ? 816 HIS A CG    1 
ATOM 5959 N ND1   . HIS A 1 816 ? 97.760  98.358  125.950 1.00 36.89  ? 816 HIS A ND1   1 
ATOM 5960 C CD2   . HIS A 1 816 ? 98.564  96.439  126.564 1.00 32.40  ? 816 HIS A CD2   1 
ATOM 5961 C CE1   . HIS A 1 816 ? 98.487  98.570  127.038 1.00 41.47  ? 816 HIS A CE1   1 
ATOM 5962 N NE2   . HIS A 1 816 ? 98.983  97.417  127.429 1.00 28.65  ? 816 HIS A NE2   1 
ATOM 5963 N N     . LEU A 1 817 ? 96.945  94.251  121.763 1.00 43.83  ? 817 LEU A N     1 
ATOM 5964 C CA    . LEU A 1 817 ? 95.978  93.501  120.916 1.00 44.34  ? 817 LEU A CA    1 
ATOM 5965 C C     . LEU A 1 817 ? 96.728  92.762  119.796 1.00 54.70  ? 817 LEU A C     1 
ATOM 5966 O O     . LEU A 1 817 ? 96.668  93.229  118.637 1.00 62.48  ? 817 LEU A O     1 
ATOM 5967 C CB    . LEU A 1 817 ? 94.925  94.458  120.359 1.00 49.70  ? 817 LEU A CB    1 
ATOM 5968 C CG    . LEU A 1 817 ? 93.505  94.272  120.901 1.00 48.95  ? 817 LEU A CG    1 
ATOM 5969 C CD1   . LEU A 1 817 ? 92.480  94.488  119.805 1.00 52.13  ? 817 LEU A CD1   1 
ATOM 5970 C CD2   . LEU A 1 817 ? 93.337  92.895  121.521 1.00 48.60  ? 817 LEU A CD2   1 
ATOM 5971 N N     . VAL A 1 818 ? 97.396  91.654  120.132 1.00 62.95  ? 818 VAL A N     1 
ATOM 5972 C CA    . VAL A 1 818 ? 98.135  90.845  119.114 1.00 67.19  ? 818 VAL A CA    1 
ATOM 5973 C C     . VAL A 1 818 ? 97.812  89.362  119.349 1.00 65.90  ? 818 VAL A C     1 
ATOM 5974 O O     . VAL A 1 818 ? 97.768  88.602  118.356 1.00 64.95  ? 818 VAL A O     1 
ATOM 5975 C CB    . VAL A 1 818 ? 99.655  91.097  119.185 1.00 66.30  ? 818 VAL A CB    1 
ATOM 5976 C CG1   . VAL A 1 818 ? 100.409 90.363  118.082 1.00 64.11  ? 818 VAL A CG1   1 
ATOM 5977 C CG2   . VAL A 1 818 ? 99.996  92.582  119.167 1.00 65.78  ? 818 VAL A CG2   1 
ATOM 5978 N N     . ASP A 1 819 ? 97.581  88.972  120.606 1.00 66.62  ? 819 ASP A N     1 
ATOM 5979 C CA    . ASP A 1 819 ? 97.326  87.569  120.936 1.00 63.68  ? 819 ASP A CA    1 
ATOM 5980 C C     . ASP A 1 819 ? 96.335  86.922  119.974 1.00 62.77  ? 819 ASP A C     1 
ATOM 5981 O O     . ASP A 1 819 ? 96.471  85.741  119.634 1.00 67.89  ? 819 ASP A O     1 
ATOM 5982 C CB    . ASP A 1 819 ? 96.811  87.467  122.370 1.00 64.71  ? 819 ASP A CB    1 
ATOM 5983 C CG    . ASP A 1 819 ? 95.932  88.641  122.755 1.00 68.09  ? 819 ASP A CG    1 
ATOM 5984 O OD1   . ASP A 1 819 ? 95.109  89.075  121.921 1.00 69.89  ? 819 ASP A OD1   1 
ATOM 5985 O OD2   . ASP A 1 819 ? 96.066  89.134  123.894 1.00 68.58  ? 819 ASP A OD2   1 
ATOM 5986 N N     . LYS A 1 820 ? 95.341  87.675  119.519 1.00 62.04  ? 820 LYS A N     1 
ATOM 5987 C CA    . LYS A 1 820 ? 94.386  87.160  118.545 1.00 65.54  ? 820 LYS A CA    1 
ATOM 5988 C C     . LYS A 1 820 ? 94.909  87.300  117.119 1.00 64.86  ? 820 LYS A C     1 
ATOM 5989 O O     . LYS A 1 820 ? 94.753  86.395  116.298 1.00 65.46  ? 820 LYS A O     1 
ATOM 5990 C CB    . LYS A 1 820 ? 93.042  87.874  118.688 1.00 64.06  ? 820 LYS A CB    1 
ATOM 5991 C CG    . LYS A 1 820 ? 92.343  87.582  119.996 1.00 63.85  ? 820 LYS A CG    1 
ATOM 5992 C CD    . LYS A 1 820 ? 91.794  88.841  120.625 1.00 63.40  ? 820 LYS A CD    1 
ATOM 5993 C CE    . LYS A 1 820 ? 91.760  88.713  122.138 1.00 64.29  ? 820 LYS A CE    1 
ATOM 5994 N NZ    . LYS A 1 820 ? 91.354  89.983  122.793 1.00 66.78  ? 820 LYS A NZ    1 
ATOM 5995 N N     . ASP A 1 838 ? 83.534  91.705  114.152 1.00 75.33  ? 838 ASP A N     1 
ATOM 5996 C CA    . ASP A 1 838 ? 84.051  93.021  113.796 1.00 77.66  ? 838 ASP A CA    1 
ATOM 5997 C C     . ASP A 1 838 ? 85.040  93.529  114.839 1.00 77.82  ? 838 ASP A C     1 
ATOM 5998 O O     . ASP A 1 838 ? 86.251  93.370  114.691 1.00 78.26  ? 838 ASP A O     1 
ATOM 5999 C CB    . ASP A 1 838 ? 82.905  94.021  113.629 1.00 78.82  ? 838 ASP A CB    1 
ATOM 6000 C CG    . ASP A 1 838 ? 82.510  94.221  112.180 1.00 77.54  ? 838 ASP A CG    1 
ATOM 6001 O OD1   . ASP A 1 838 ? 83.414  94.341  111.327 1.00 75.86  ? 838 ASP A OD1   1 
ATOM 6002 O OD2   . ASP A 1 838 ? 81.295  94.259  111.892 1.00 78.85  ? 838 ASP A OD2   1 
ATOM 6003 N N     . HIS A 1 839 ? 84.514  94.145  115.897 1.00 74.04  ? 839 HIS A N     1 
ATOM 6004 C CA    . HIS A 1 839 ? 85.338  94.729  116.947 1.00 72.11  ? 839 HIS A CA    1 
ATOM 6005 C C     . HIS A 1 839 ? 85.184  94.009  118.280 1.00 72.01  ? 839 HIS A C     1 
ATOM 6006 O O     . HIS A 1 839 ? 85.564  94.571  119.314 1.00 69.23  ? 839 HIS A O     1 
ATOM 6007 C CB    . HIS A 1 839 ? 85.001  96.213  117.127 1.00 69.35  ? 839 HIS A CB    1 
ATOM 6008 C CG    . HIS A 1 839 ? 85.394  97.073  115.966 1.00 69.56  ? 839 HIS A CG    1 
ATOM 6009 N ND1   . HIS A 1 839 ? 85.008  98.391  115.855 1.00 71.20  ? 839 HIS A ND1   1 
ATOM 6010 C CD2   . HIS A 1 839 ? 86.135  96.804  114.865 1.00 71.70  ? 839 HIS A CD2   1 
ATOM 6011 C CE1   . HIS A 1 839 ? 85.495  98.899  114.737 1.00 75.00  ? 839 HIS A CE1   1 
ATOM 6012 N NE2   . HIS A 1 839 ? 86.183  97.956  114.118 1.00 71.41  ? 839 HIS A NE2   1 
ATOM 6013 N N     . GLN A 1 840 ? 84.628  92.793  118.288 1.00 77.94  ? 840 GLN A N     1 
ATOM 6014 C CA    . GLN A 1 840 ? 84.391  92.087  119.546 1.00 78.68  ? 840 GLN A CA    1 
ATOM 6015 C C     . GLN A 1 840 ? 85.695  91.604  120.173 1.00 79.34  ? 840 GLN A C     1 
ATOM 6016 O O     . GLN A 1 840 ? 85.841  91.611  121.403 1.00 80.17  ? 840 GLN A O     1 
ATOM 6017 C CB    . GLN A 1 840 ? 83.424  90.921  119.324 1.00 76.35  ? 840 GLN A CB    1 
ATOM 6018 C CG    . GLN A 1 840 ? 83.741  90.044  118.122 1.00 81.43  ? 840 GLN A CG    1 
ATOM 6019 C CD    . GLN A 1 840 ? 84.578  88.835  118.490 1.00 79.46  ? 840 GLN A CD    1 
ATOM 6020 O OE1   . GLN A 1 840 ? 84.688  88.476  119.661 1.00 76.91  ? 840 GLN A OE1   1 
ATOM 6021 N NE2   . GLN A 1 840 ? 85.177  88.201  117.488 1.00 80.05  ? 840 GLN A NE2   1 
ATOM 6022 N N     . ALA A 1 841 ? 86.662  91.201  119.341 1.00 74.16  ? 841 ALA A N     1 
ATOM 6023 C CA    . ALA A 1 841 ? 87.985  90.855  119.848 1.00 75.92  ? 841 ALA A CA    1 
ATOM 6024 C C     . ALA A 1 841 ? 88.719  92.093  120.346 1.00 74.75  ? 841 ALA A C     1 
ATOM 6025 O O     . ALA A 1 841 ? 89.566  92.007  121.243 1.00 68.32  ? 841 ALA A O     1 
ATOM 6026 C CB    . ALA A 1 841 ? 88.796  90.146  118.763 1.00 73.41  ? 841 ALA A CB    1 
ATOM 6027 N N     . LEU A 1 842 ? 88.411  93.256  119.768 1.00 75.69  ? 842 LEU A N     1 
ATOM 6028 C CA    . LEU A 1 842 ? 88.927  94.504  120.312 1.00 74.11  ? 842 LEU A CA    1 
ATOM 6029 C C     . LEU A 1 842 ? 88.212  94.855  121.611 1.00 77.67  ? 842 LEU A C     1 
ATOM 6030 O O     . LEU A 1 842 ? 88.854  95.234  122.596 1.00 81.62  ? 842 LEU A O     1 
ATOM 6031 C CB    . LEU A 1 842 ? 88.790  95.622  119.270 1.00 72.48  ? 842 LEU A CB    1 
ATOM 6032 C CG    . LEU A 1 842 ? 89.453  97.011  119.355 1.00 73.23  ? 842 LEU A CG    1 
ATOM 6033 C CD1   . LEU A 1 842 ? 89.448  97.615  117.961 1.00 71.92  ? 842 LEU A CD1   1 
ATOM 6034 C CD2   . LEU A 1 842 ? 88.818  98.011  120.329 1.00 73.13  ? 842 LEU A CD2   1 
ATOM 6035 N N     . ALA A 1 843 ? 86.884  94.715  121.638 1.00 75.78  ? 843 ALA A N     1 
ATOM 6036 C CA    . ALA A 1 843 ? 86.106  95.167  122.787 1.00 78.04  ? 843 ALA A CA    1 
ATOM 6037 C C     . ALA A 1 843 ? 86.229  94.243  123.989 1.00 77.80  ? 843 ALA A C     1 
ATOM 6038 O O     . ALA A 1 843 ? 85.844  94.638  125.094 1.00 74.75  ? 843 ALA A O     1 
ATOM 6039 C CB    . ALA A 1 843 ? 84.632  95.320  122.408 1.00 76.04  ? 843 ALA A CB    1 
ATOM 6040 N N     . LYS A 1 844 ? 86.742  93.026  123.810 1.00 77.20  ? 844 LYS A N     1 
ATOM 6041 C CA    . LYS A 1 844 ? 86.899  92.121  124.939 1.00 78.83  ? 844 LYS A CA    1 
ATOM 6042 C C     . LYS A 1 844 ? 88.197  92.333  125.713 1.00 78.68  ? 844 LYS A C     1 
ATOM 6043 O O     . LYS A 1 844 ? 88.340  91.772  126.805 1.00 79.94  ? 844 LYS A O     1 
ATOM 6044 C CB    . LYS A 1 844 ? 86.822  90.664  124.469 1.00 77.22  ? 844 LYS A CB    1 
ATOM 6045 C CG    . LYS A 1 844 ? 87.985  90.221  123.602 1.00 80.37  ? 844 LYS A CG    1 
ATOM 6046 C CD    . LYS A 1 844 ? 88.311  88.754  123.833 1.00 78.91  ? 844 LYS A CD    1 
ATOM 6047 C CE    . LYS A 1 844 ? 87.326  87.849  123.112 1.00 78.68  ? 844 LYS A CE    1 
ATOM 6048 N NZ    . LYS A 1 844 ? 87.702  86.411  123.229 1.00 77.49  ? 844 LYS A NZ    1 
ATOM 6049 N N     . ALA A 1 845 ? 89.134  93.125  125.196 1.00 71.36  ? 845 ALA A N     1 
ATOM 6050 C CA    . ALA A 1 845 ? 90.441  93.289  125.833 1.00 68.16  ? 845 ALA A CA    1 
ATOM 6051 C C     . ALA A 1 845 ? 90.875  94.752  125.828 1.00 63.99  ? 845 ALA A C     1 
ATOM 6052 O O     . ALA A 1 845 ? 92.027  95.083  125.549 1.00 58.73  ? 845 ALA A O     1 
ATOM 6053 C CB    . ALA A 1 845 ? 91.493  92.416  125.153 1.00 63.92  ? 845 ALA A CB    1 
ATOM 6054 N N     . VAL A 1 846 ? 89.943  95.653  126.147 1.00 67.09  ? 846 VAL A N     1 
ATOM 6055 C CA    . VAL A 1 846 ? 90.257  97.067  126.306 1.00 70.37  ? 846 VAL A CA    1 
ATOM 6056 C C     . VAL A 1 846 ? 89.885  97.599  127.679 1.00 75.49  ? 846 VAL A C     1 
ATOM 6057 O O     . VAL A 1 846 ? 90.175  98.758  127.979 1.00 74.66  ? 846 VAL A O     1 
ATOM 6058 C CB    . VAL A 1 846 ? 89.589  97.922  125.211 1.00 67.96  ? 846 VAL A CB    1 
ATOM 6059 C CG1   . VAL A 1 846 ? 90.394  97.857  123.927 1.00 64.87  ? 846 VAL A CG1   1 
ATOM 6060 C CG2   . VAL A 1 846 ? 88.154  97.478  124.992 1.00 66.83  ? 846 VAL A CG2   1 
ATOM 6061 N N     . GLN A 1 847 ? 89.254  96.787  128.529 1.00 64.82  ? 847 GLN A N     1 
ATOM 6062 C CA    . GLN A 1 847 ? 88.848  97.211  129.868 1.00 60.02  ? 847 GLN A CA    1 
ATOM 6063 C C     . GLN A 1 847 ? 90.096  97.289  130.743 1.00 65.51  ? 847 GLN A C     1 
ATOM 6064 O O     . GLN A 1 847 ? 90.499  96.330  131.405 1.00 64.63  ? 847 GLN A O     1 
ATOM 6065 C CB    . GLN A 1 847 ? 87.813  96.255  130.446 1.00 61.86  ? 847 GLN A CB    1 
ATOM 6066 C CG    . GLN A 1 847 ? 86.746  95.807  129.457 1.00 67.44  ? 847 GLN A CG    1 
ATOM 6067 C CD    . GLN A 1 847 ? 85.979  96.968  128.861 1.00 68.25  ? 847 GLN A CD    1 
ATOM 6068 O OE1   . GLN A 1 847 ? 86.097  97.262  127.672 1.00 68.69  ? 847 GLN A OE1   1 
ATOM 6069 N NE2   . GLN A 1 847 ? 85.186  97.636  129.688 1.00 69.96  ? 847 GLN A NE2   1 
ATOM 6070 N N     . VAL A 1 848 ? 90.721  98.469  130.733 1.00 69.66  ? 848 VAL A N     1 
ATOM 6071 C CA    . VAL A 1 848 ? 91.973  98.662  131.452 1.00 70.00  ? 848 VAL A CA    1 
ATOM 6072 C C     . VAL A 1 848 ? 91.709  98.790  132.947 1.00 73.26  ? 848 VAL A C     1 
ATOM 6073 O O     . VAL A 1 848 ? 90.696  99.359  133.380 1.00 72.96  ? 848 VAL A O     1 
ATOM 6074 C CB    . VAL A 1 848 ? 92.731  99.879  130.893 1.00 68.14  ? 848 VAL A CB    1 
ATOM 6075 C CG1   . VAL A 1 848 ? 93.248  99.565  129.504 1.00 63.54  ? 848 VAL A CG1   1 
ATOM 6076 C CG2   . VAL A 1 848 ? 91.831  101.099 130.834 1.00 66.00  ? 848 VAL A CG2   1 
ATOM 6077 N N     . HIS A 1 849 ? 92.615  98.233  133.746 1.00 73.23  ? 849 HIS A N     1 
ATOM 6078 C CA    . HIS A 1 849 ? 92.405  98.130  135.181 1.00 70.06  ? 849 HIS A CA    1 
ATOM 6079 C C     . HIS A 1 849 ? 92.719  99.451  135.875 1.00 66.29  ? 849 HIS A C     1 
ATOM 6080 O O     . HIS A 1 849 ? 93.546  100.242 135.419 1.00 61.65  ? 849 HIS A O     1 
ATOM 6081 C CB    . HIS A 1 849 ? 93.271  97.016  135.766 1.00 67.40  ? 849 HIS A CB    1 
ATOM 6082 C CG    . HIS A 1 849 ? 92.628  96.295  136.905 1.00 69.85  ? 849 HIS A CG    1 
ATOM 6083 N ND1   . HIS A 1 849 ? 91.830  95.185  136.728 1.00 70.73  ? 849 HIS A ND1   1 
ATOM 6084 C CD2   . HIS A 1 849 ? 92.646  96.536  138.237 1.00 68.09  ? 849 HIS A CD2   1 
ATOM 6085 C CE1   . HIS A 1 849 ? 91.394  94.767  137.903 1.00 67.46  ? 849 HIS A CE1   1 
ATOM 6086 N NE2   . HIS A 1 849 ? 91.877  95.568  138.835 1.00 65.92  ? 849 HIS A NE2   1 
ATOM 6087 N N     . GLN A 1 850 ? 92.051  99.679  137.004 1.00 69.30  ? 850 GLN A N     1 
ATOM 6088 C CA    . GLN A 1 850 ? 92.231  100.905 137.770 1.00 72.03  ? 850 GLN A CA    1 
ATOM 6089 C C     . GLN A 1 850 ? 93.536  100.936 138.557 1.00 76.01  ? 850 GLN A C     1 
ATOM 6090 O O     . GLN A 1 850 ? 93.952  102.014 138.996 1.00 77.08  ? 850 GLN A O     1 
ATOM 6091 C CB    . GLN A 1 850 ? 91.048  101.107 138.728 1.00 70.51  ? 850 GLN A CB    1 
ATOM 6092 C CG    . GLN A 1 850 ? 90.703  102.567 139.013 1.00 74.14  ? 850 GLN A CG    1 
ATOM 6093 C CD    . GLN A 1 850 ? 90.538  103.392 137.750 1.00 77.22  ? 850 GLN A CD    1 
ATOM 6094 O OE1   . GLN A 1 850 ? 89.712  103.079 136.892 1.00 76.66  ? 850 GLN A OE1   1 
ATOM 6095 N NE2   . GLN A 1 850 ? 91.330  104.451 137.628 1.00 74.87  ? 850 GLN A NE2   1 
ATOM 6096 N N     . ASP A 1 851 ? 94.201  99.798  138.730 1.00 75.79  ? 851 ASP A N     1 
ATOM 6097 C CA    . ASP A 1 851 ? 95.421  99.729  139.522 1.00 73.37  ? 851 ASP A CA    1 
ATOM 6098 C C     . ASP A 1 851 ? 96.677  100.034 138.717 1.00 73.12  ? 851 ASP A C     1 
ATOM 6099 O O     . ASP A 1 851 ? 97.782  99.907  139.254 1.00 72.97  ? 851 ASP A O     1 
ATOM 6100 C CB    . ASP A 1 851 ? 95.552  98.349  140.168 1.00 70.63  ? 851 ASP A CB    1 
ATOM 6101 C CG    . ASP A 1 851 ? 94.394  98.022  141.081 1.00 74.20  ? 851 ASP A CG    1 
ATOM 6102 O OD1   . ASP A 1 851 ? 93.704  98.963  141.523 1.00 75.05  ? 851 ASP A OD1   1 
ATOM 6103 O OD2   . ASP A 1 851 ? 94.174  96.825  141.357 1.00 71.25  ? 851 ASP A OD2   1 
ATOM 6104 N N     . THR A 1 852 ? 96.543  100.415 137.447 1.00 60.40  ? 852 THR A N     1 
ATOM 6105 C CA    . THR A 1 852 ? 97.696  100.725 136.612 1.00 50.61  ? 852 THR A CA    1 
ATOM 6106 C C     . THR A 1 852 ? 97.617  102.108 135.977 1.00 49.78  ? 852 THR A C     1 
ATOM 6107 O O     . THR A 1 852 ? 98.667  102.694 135.684 1.00 55.74  ? 852 THR A O     1 
ATOM 6108 C CB    . THR A 1 852 ? 97.848  99.660  135.513 1.00 62.48  ? 852 THR A CB    1 
ATOM 6109 O OG1   . THR A 1 852 ? 97.665  98.374  136.103 1.00 65.24  ? 852 THR A OG1   1 
ATOM 6110 C CG2   . THR A 1 852 ? 99.260  99.638  134.951 1.00 61.85  ? 852 THR A CG2   1 
ATOM 6111 N N     . LEU A 1 853 ? 96.420  102.682 135.822 1.00 42.07  ? 853 LEU A N     1 
ATOM 6112 C CA    . LEU A 1 853 ? 96.281  104.011 135.233 1.00 43.19  ? 853 LEU A CA    1 
ATOM 6113 C C     . LEU A 1 853 ? 96.837  105.122 136.120 1.00 43.73  ? 853 LEU A C     1 
ATOM 6114 O O     . LEU A 1 853 ? 97.055  106.234 135.628 1.00 39.50  ? 853 LEU A O     1 
ATOM 6115 C CB    . LEU A 1 853 ? 94.814  104.293 134.911 1.00 47.44  ? 853 LEU A CB    1 
ATOM 6116 C CG    . LEU A 1 853 ? 94.018  103.267 134.104 1.00 57.77  ? 853 LEU A CG    1 
ATOM 6117 C CD1   . LEU A 1 853 ? 92.542  103.297 134.491 1.00 53.73  ? 853 LEU A CD1   1 
ATOM 6118 C CD2   . LEU A 1 853 ? 94.191  103.512 132.612 1.00 52.31  ? 853 LEU A CD2   1 
ATOM 6119 N N     . ARG A 1 854 ? 97.059  104.859 137.409 1.00 45.89  ? 854 ARG A N     1 
ATOM 6120 C CA    . ARG A 1 854 ? 97.830  105.775 138.239 1.00 48.31  ? 854 ARG A CA    1 
ATOM 6121 C C     . ARG A 1 854 ? 99.333  105.637 138.012 1.00 48.56  ? 854 ARG A C     1 
ATOM 6122 O O     . ARG A 1 854 ? 100.076 106.590 138.272 1.00 45.58  ? 854 ARG A O     1 
ATOM 6123 C CB    . ARG A 1 854 ? 97.471  105.561 139.720 1.00 45.58  ? 854 ARG A CB    1 
ATOM 6124 C CG    . ARG A 1 854 ? 98.517  104.846 140.575 1.00 49.41  ? 854 ARG A CG    1 
ATOM 6125 C CD    . ARG A 1 854 ? 98.016  104.542 141.977 1.00 45.12  ? 854 ARG A CD    1 
ATOM 6126 N NE    . ARG A 1 854 ? 98.838  103.539 142.647 1.00 46.70  ? 854 ARG A NE    1 
ATOM 6127 C CZ    . ARG A 1 854 ? 99.994  103.786 143.252 1.00 47.86  ? 854 ARG A CZ    1 
ATOM 6128 N NH1   . ARG A 1 854 ? 100.495 105.009 143.318 1.00 50.52  ? 854 ARG A NH1   1 
ATOM 6129 N NH2   . ARG A 1 854 ? 100.659 102.780 143.813 1.00 46.91  ? 854 ARG A NH2   1 
ATOM 6130 N N     . THR A 1 855 ? 99.789  104.501 137.496 1.00 46.29  ? 855 THR A N     1 
ATOM 6131 C CA    . THR A 1 855 ? 101.200 104.206 137.288 1.00 39.93  ? 855 THR A CA    1 
ATOM 6132 C C     . THR A 1 855 ? 101.528 104.292 135.802 1.00 45.54  ? 855 THR A C     1 
ATOM 6133 O O     . THR A 1 855 ? 100.717 104.731 134.985 1.00 42.47  ? 855 THR A O     1 
ATOM 6134 C CB    . THR A 1 855 ? 101.566 102.821 137.826 1.00 47.20  ? 855 THR A CB    1 
ATOM 6135 O OG1   . THR A 1 855 ? 100.808 101.820 137.137 1.00 44.30  ? 855 THR A OG1   1 
ATOM 6136 C CG2   . THR A 1 855 ? 101.300 102.733 139.314 1.00 50.73  ? 855 THR A CG2   1 
ATOM 6137 N N     . MET A 1 856 ? 102.743 103.880 135.460 1.00 49.05  ? 856 MET A N     1 
ATOM 6138 C CA    . MET A 1 856 ? 103.172 103.802 134.074 1.00 41.19  ? 856 MET A CA    1 
ATOM 6139 C C     . MET A 1 856 ? 103.215 102.364 133.586 1.00 41.16  ? 856 MET A C     1 
ATOM 6140 O O     . MET A 1 856 ? 103.225 101.407 134.363 1.00 49.20  ? 856 MET A O     1 
ATOM 6141 C CB    . MET A 1 856 ? 104.555 104.409 133.882 1.00 35.31  ? 856 MET A CB    1 
ATOM 6142 C CG    . MET A 1 856 ? 104.849 105.572 134.733 1.00 38.72  ? 856 MET A CG    1 
ATOM 6143 S SD    . MET A 1 856 ? 103.784 106.964 134.455 1.00 62.90  ? 856 MET A SD    1 
ATOM 6144 C CE    . MET A 1 856 ? 105.041 108.221 134.583 1.00 36.39  ? 856 MET A CE    1 
ATOM 6145 N N     . TYR A 1 857 ? 103.232 102.228 132.264 1.00 18.81  ? 857 TYR A N     1 
ATOM 6146 C CA    . TYR A 1 857 ? 103.467 100.933 131.651 1.00 18.70  ? 857 TYR A CA    1 
ATOM 6147 C C     . TYR A 1 857 ? 104.270 101.081 130.366 1.00 28.70  ? 857 TYR A C     1 
ATOM 6148 O O     . TYR A 1 857 ? 104.186 100.221 129.484 1.00 30.72  ? 857 TYR A O     1 
ATOM 6149 C CB    . TYR A 1 857 ? 102.142 100.196 131.402 1.00 34.39  ? 857 TYR A CB    1 
ATOM 6150 C CG    . TYR A 1 857 ? 100.928 101.048 131.049 1.00 30.58  ? 857 TYR A CG    1 
ATOM 6151 C CD1   . TYR A 1 857 ? 100.126 101.618 132.038 1.00 27.91  ? 857 TYR A CD1   1 
ATOM 6152 C CD2   . TYR A 1 857 ? 100.526 101.190 129.731 1.00 29.72  ? 857 TYR A CD2   1 
ATOM 6153 C CE1   . TYR A 1 857 ? 99.018  102.367 131.713 1.00 28.79  ? 857 TYR A CE1   1 
ATOM 6154 C CE2   . TYR A 1 857 ? 99.405  101.912 129.407 1.00 30.52  ? 857 TYR A CE2   1 
ATOM 6155 C CZ    . TYR A 1 857 ? 98.664  102.506 130.395 1.00 33.33  ? 857 TYR A CZ    1 
ATOM 6156 O OH    . TYR A 1 857 ? 97.551  103.235 130.056 1.00 42.83  ? 857 TYR A OH    1 
ATOM 6157 N N     . PHE A 1 858 ? 105.049 102.157 130.246 1.00 27.76  ? 858 PHE A N     1 
ATOM 6158 C CA    . PHE A 1 858 ? 105.674 102.534 128.981 1.00 31.80  ? 858 PHE A CA    1 
ATOM 6159 C C     . PHE A 1 858 ? 107.160 102.843 129.088 1.00 27.09  ? 858 PHE A C     1 
ATOM 6160 O O     . PHE A 1 858 ? 107.884 102.673 128.105 1.00 36.04  ? 858 PHE A O     1 
ATOM 6161 C CB    . PHE A 1 858 ? 104.933 103.752 128.379 1.00 19.97  ? 858 PHE A CB    1 
ATOM 6162 C CG    . PHE A 1 858 ? 104.788 104.917 129.325 1.00 2.26   ? 858 PHE A CG    1 
ATOM 6163 C CD1   . PHE A 1 858 ? 105.792 105.867 129.446 1.00 20.18  ? 858 PHE A CD1   1 
ATOM 6164 C CD2   . PHE A 1 858 ? 103.634 105.084 130.067 1.00 13.12  ? 858 PHE A CD2   1 
ATOM 6165 C CE1   . PHE A 1 858 ? 105.663 106.923 130.308 1.00 30.39  ? 858 PHE A CE1   1 
ATOM 6166 C CE2   . PHE A 1 858 ? 103.506 106.148 130.928 1.00 10.06  ? 858 PHE A CE2   1 
ATOM 6167 C CZ    . PHE A 1 858 ? 104.512 107.069 131.035 1.00 20.45  ? 858 PHE A CZ    1 
ATOM 6168 N N     . ALA A 1 859 ? 107.629 103.310 130.238 1.00 13.71  ? 859 ALA A N     1 
ATOM 6169 C CA    . ALA A 1 859 ? 108.998 103.797 130.367 1.00 6.81   ? 859 ALA A CA    1 
ATOM 6170 C C     . ALA A 1 859 ? 109.991 102.668 130.615 1.00 21.92  ? 859 ALA A C     1 
ATOM 6171 O O     . ALA A 1 859 ? 111.124 102.705 130.135 1.00 20.05  ? 859 ALA A O     1 
ATOM 6172 C CB    . ALA A 1 859 ? 109.082 104.825 131.480 1.00 6.51   ? 859 ALA A CB    1 
ATOM 6173 O OP3   . U   B 2 1   ? 107.950 97.666  129.646 1.00 37.26  ? 1   U   B OP3   1 
ATOM 6174 P P     . U   B 2 1   ? 108.941 98.606  129.091 1.00 29.18  ? 1   U   B P     1 
ATOM 6175 O OP1   . U   B 2 1   ? 108.276 99.915  128.978 1.00 34.76  ? 1   U   B OP1   1 
ATOM 6176 O OP2   . U   B 2 1   ? 110.174 98.499  129.899 1.00 34.60  ? 1   U   B OP2   1 
ATOM 6177 O "O5'" . U   B 2 1   ? 109.288 98.161  127.605 1.00 28.33  ? 1   U   B "O5'" 1 
ATOM 6178 C "C5'" . U   B 2 1   ? 110.549 98.467  127.025 1.00 30.10  ? 1   U   B "C5'" 1 
ATOM 6179 C "C4'" . U   B 2 1   ? 111.469 97.275  127.070 1.00 37.28  ? 1   U   B "C4'" 1 
ATOM 6180 O "O4'" . U   B 2 1   ? 110.892 96.185  126.301 1.00 43.96  ? 1   U   B "O4'" 1 
ATOM 6181 C "C3'" . U   B 2 1   ? 112.865 97.497  126.499 1.00 36.44  ? 1   U   B "C3'" 1 
ATOM 6182 O "O3'" . U   B 2 1   ? 113.769 96.658  127.204 1.00 33.41  ? 1   U   B "O3'" 1 
ATOM 6183 C "C2'" . U   B 2 1   ? 112.723 96.968  125.080 1.00 42.35  ? 1   U   B "C2'" 1 
ATOM 6184 O "O2'" . U   B 2 1   ? 113.938 96.595  124.469 1.00 47.71  ? 1   U   B "O2'" 1 
ATOM 6185 C "C1'" . U   B 2 1   ? 111.811 95.771  125.310 1.00 36.94  ? 1   U   B "C1'" 1 
ATOM 6186 N N1    . U   B 2 1   ? 111.051 95.348  124.128 1.00 35.37  ? 1   U   B N1    1 
ATOM 6187 C C2    . U   B 2 1   ? 111.010 93.991  123.875 1.00 29.54  ? 1   U   B C2    1 
ATOM 6188 O O2    . U   B 2 1   ? 111.569 93.167  124.578 1.00 26.81  ? 1   U   B O2    1 
ATOM 6189 N N3    . U   B 2 1   ? 110.282 93.642  122.768 1.00 30.06  ? 1   U   B N3    1 
ATOM 6190 C C4    . U   B 2 1   ? 109.612 94.496  121.917 1.00 27.42  ? 1   U   B C4    1 
ATOM 6191 O O4    . U   B 2 1   ? 109.000 94.029  120.957 1.00 35.85  ? 1   U   B O4    1 
ATOM 6192 C C5    . U   B 2 1   ? 109.707 95.884  122.248 1.00 33.34  ? 1   U   B C5    1 
ATOM 6193 C C6    . U   B 2 1   ? 110.419 96.261  123.313 1.00 41.37  ? 1   U   B C6    1 
ATOM 6194 P P     . A   B 2 2   ? 115.270 97.135  127.473 1.00 20.76  ? 2   A   B P     1 
ATOM 6195 O OP1   . A   B 2 2   ? 115.800 97.772  126.248 1.00 39.36  ? 2   A   B OP1   1 
ATOM 6196 O OP2   . A   B 2 2   ? 115.967 95.978  128.071 1.00 39.50  ? 2   A   B OP2   1 
ATOM 6197 O "O5'" . A   B 2 2   ? 115.124 98.260  128.584 1.00 31.49  ? 2   A   B "O5'" 1 
ATOM 6198 C "C5'" . A   B 2 2   ? 116.190 98.521  129.478 1.00 36.21  ? 2   A   B "C5'" 1 
ATOM 6199 C "C4'" . A   B 2 2   ? 116.350 99.995  129.754 1.00 37.86  ? 2   A   B "C4'" 1 
ATOM 6200 O "O4'" . A   B 2 2   ? 117.735 100.253 130.081 1.00 43.63  ? 2   A   B "O4'" 1 
ATOM 6201 C "C3'" . A   B 2 2   ? 116.044 100.938 128.596 1.00 35.33  ? 2   A   B "C3'" 1 
ATOM 6202 O "O3'" . A   B 2 2   ? 114.672 101.293 128.552 1.00 26.01  ? 2   A   B "O3'" 1 
ATOM 6203 C "C2'" . A   B 2 2   ? 116.935 102.135 128.879 1.00 37.37  ? 2   A   B "C2'" 1 
ATOM 6204 O "O2'" . A   B 2 2   ? 116.300 103.009 129.794 1.00 39.30  ? 2   A   B "O2'" 1 
ATOM 6205 C "C1'" . A   B 2 2   ? 118.133 101.500 129.570 1.00 43.63  ? 2   A   B "C1'" 1 
ATOM 6206 N N9    . A   B 2 2   ? 119.325 101.299 128.720 1.00 40.22  ? 2   A   B N9    1 
ATOM 6207 C C8    . A   B 2 2   ? 119.689 100.096 128.194 1.00 51.28  ? 2   A   B C8    1 
ATOM 6208 N N7    . A   B 2 2   ? 120.803 100.093 127.513 1.00 49.12  ? 2   A   B N7    1 
ATOM 6209 C C5    . A   B 2 2   ? 121.231 101.402 127.610 1.00 41.95  ? 2   A   B C5    1 
ATOM 6210 C C6    . A   B 2 2   ? 122.367 102.049 127.096 1.00 47.01  ? 2   A   B C6    1 
ATOM 6211 N N6    . A   B 2 2   ? 123.296 101.435 126.359 1.00 48.34  ? 2   A   B N6    1 
ATOM 6212 N N1    . A   B 2 2   ? 122.524 103.362 127.361 1.00 47.55  ? 2   A   B N1    1 
ATOM 6213 C C2    . A   B 2 2   ? 121.592 103.977 128.095 1.00 45.32  ? 2   A   B C2    1 
ATOM 6214 N N3    . A   B 2 2   ? 120.481 103.470 128.640 1.00 39.04  ? 2   A   B N3    1 
ATOM 6215 C C4    . A   B 2 2   ? 120.347 102.161 128.363 1.00 32.56  ? 2   A   B C4    1 
ATOM 6216 P P     . C   B 2 3   ? 113.939 101.644 127.165 1.00 41.60  ? 3   C   B P     1 
ATOM 6217 O OP1   . C   B 2 3   ? 112.539 102.010 127.482 1.00 35.75  ? 3   C   B OP1   1 
ATOM 6218 O OP2   . C   B 2 3   ? 114.242 100.582 126.175 1.00 43.99  ? 3   C   B OP2   1 
ATOM 6219 O "O5'" . C   B 2 3   ? 114.623 102.991 126.676 1.00 40.00  ? 3   C   B "O5'" 1 
ATOM 6220 C "C5'" . C   B 2 3   ? 114.119 104.253 127.082 1.00 37.51  ? 3   C   B "C5'" 1 
ATOM 6221 C "C4'" . C   B 2 3   ? 115.128 105.343 126.832 1.00 42.64  ? 3   C   B "C4'" 1 
ATOM 6222 O "O4'" . C   B 2 3   ? 116.442 104.876 127.219 1.00 44.12  ? 3   C   B "O4'" 1 
ATOM 6223 C "C3'" . C   B 2 3   ? 115.307 105.768 125.388 1.00 39.41  ? 3   C   B "C3'" 1 
ATOM 6224 O "O3'" . C   B 2 3   ? 114.327 106.694 124.967 1.00 32.01  ? 3   C   B "O3'" 1 
ATOM 6225 C "C2'" . C   B 2 3   ? 116.709 106.348 125.386 1.00 40.38  ? 3   C   B "C2'" 1 
ATOM 6226 O "O2'" . C   B 2 3   ? 116.698 107.666 125.903 1.00 45.08  ? 3   C   B "O2'" 1 
ATOM 6227 C "C1'" . C   B 2 3   ? 117.422 105.460 126.396 1.00 40.03  ? 3   C   B "C1'" 1 
ATOM 6228 N N1    . C   B 2 3   ? 118.285 104.415 125.784 1.00 39.86  ? 3   C   B N1    1 
ATOM 6229 C C2    . C   B 2 3   ? 119.583 104.759 125.394 1.00 38.16  ? 3   C   B C2    1 
ATOM 6230 O O2    . C   B 2 3   ? 119.964 105.927 125.541 1.00 36.93  ? 3   C   B O2    1 
ATOM 6231 N N3    . C   B 2 3   ? 120.391 103.824 124.846 1.00 47.82  ? 3   C   B N3    1 
ATOM 6232 C C4    . C   B 2 3   ? 119.964 102.573 124.692 1.00 45.74  ? 3   C   B C4    1 
ATOM 6233 N N4    . C   B 2 3   ? 120.801 101.685 124.151 1.00 42.67  ? 3   C   B N4    1 
ATOM 6234 C C5    . C   B 2 3   ? 118.662 102.177 125.090 1.00 46.24  ? 3   C   B C5    1 
ATOM 6235 C C6    . C   B 2 3   ? 117.876 103.125 125.614 1.00 48.97  ? 3   C   B C6    1 
ATOM 6236 P P     . A   B 2 4   ? 113.955 106.823 123.410 1.00 64.73  ? 4   A   B P     1 
ATOM 6237 O OP1   . A   B 2 4   ? 112.703 107.622 123.332 1.00 50.13  ? 4   A   B OP1   1 
ATOM 6238 O OP2   . A   B 2 4   ? 114.009 105.470 122.800 1.00 59.07  ? 4   A   B OP2   1 
ATOM 6239 O "O5'" . A   B 2 4   ? 115.154 107.671 122.785 1.00 69.43  ? 4   A   B "O5'" 1 
ATOM 6240 C "C5'" . A   B 2 4   ? 115.402 109.001 123.216 1.00 64.41  ? 4   A   B "C5'" 1 
ATOM 6241 C "C4'" . A   B 2 4   ? 116.740 109.523 122.762 1.00 47.51  ? 4   A   B "C4'" 1 
ATOM 6242 O "O4'" . A   B 2 4   ? 117.826 108.788 123.393 1.00 52.11  ? 4   A   B "O4'" 1 
ATOM 6243 C "C3'" . A   B 2 4   ? 117.053 109.366 121.298 1.00 44.40  ? 4   A   B "C3'" 1 
ATOM 6244 O "O3'" . A   B 2 4   ? 116.229 110.110 120.395 1.00 53.12  ? 4   A   B "O3'" 1 
ATOM 6245 C "C2'" . A   B 2 4   ? 118.573 109.553 121.278 1.00 48.84  ? 4   A   B "C2'" 1 
ATOM 6246 O "O2'" . A   B 2 4   ? 118.974 110.896 121.506 1.00 60.38  ? 4   A   B "O2'" 1 
ATOM 6247 C "C1'" . A   B 2 4   ? 118.955 108.782 122.528 1.00 48.31  ? 4   A   B "C1'" 1 
ATOM 6248 N N9    . A   B 2 4   ? 119.376 107.401 122.225 1.00 53.76  ? 4   A   B N9    1 
ATOM 6249 C C8    . A   B 2 4   ? 118.751 106.237 122.562 1.00 55.43  ? 4   A   B C8    1 
ATOM 6250 N N7    . A   B 2 4   ? 119.374 105.151 122.182 1.00 55.25  ? 4   A   B N7    1 
ATOM 6251 C C5    . A   B 2 4   ? 120.494 105.636 121.531 1.00 55.93  ? 4   A   B C5    1 
ATOM 6252 C C6    . A   B 2 4   ? 121.564 104.993 120.883 1.00 57.91  ? 4   A   B C6    1 
ATOM 6253 N N6    . A   B 2 4   ? 121.674 103.667 120.792 1.00 58.36  ? 4   A   B N6    1 
ATOM 6254 N N1    . A   B 2 4   ? 122.531 105.757 120.327 1.00 61.54  ? 4   A   B N1    1 
ATOM 6255 C C2    . A   B 2 4   ? 122.424 107.089 120.419 1.00 60.87  ? 4   A   B C2    1 
ATOM 6256 N N3    . A   B 2 4   ? 121.463 107.804 121.004 1.00 60.85  ? 4   A   B N3    1 
ATOM 6257 C C4    . A   B 2 4   ? 120.510 107.019 121.540 1.00 54.41  ? 4   A   B C4    1 
ATOM 6258 P P     . A   B 2 5   ? 116.298 111.697 120.146 1.00 55.66  ? 5   A   B P     1 
ATOM 6259 O OP1   . A   B 2 5   ? 117.114 112.397 121.163 1.00 55.60  ? 5   A   B OP1   1 
ATOM 6260 O OP2   . A   B 2 5   ? 114.914 112.160 119.935 1.00 50.68  ? 5   A   B OP2   1 
ATOM 6261 O "O5'" . A   B 2 5   ? 117.057 111.816 118.751 1.00 63.35  ? 5   A   B "O5'" 1 
ATOM 6262 C "C5'" . A   B 2 5   ? 118.258 112.562 118.631 1.00 54.63  ? 5   A   B "C5'" 1 
ATOM 6263 C "C4'" . A   B 2 5   ? 119.176 111.974 117.589 1.00 51.89  ? 5   A   B "C4'" 1 
ATOM 6264 O "O4'" . A   B 2 5   ? 119.845 110.812 118.119 1.00 48.47  ? 5   A   B "O4'" 1 
ATOM 6265 C "C3'" . A   B 2 5   ? 118.520 111.472 116.313 1.00 61.24  ? 5   A   B "C3'" 1 
ATOM 6266 O "O3'" . A   B 2 5   ? 118.266 112.519 115.391 1.00 65.61  ? 5   A   B "O3'" 1 
ATOM 6267 C "C2'" . A   B 2 5   ? 119.519 110.437 115.785 1.00 65.06  ? 5   A   B "C2'" 1 
ATOM 6268 O "O2'" . A   B 2 5   ? 120.516 111.060 114.988 1.00 58.66  ? 5   A   B "O2'" 1 
ATOM 6269 C "C1'" . A   B 2 5   ? 120.198 109.948 117.064 1.00 58.46  ? 5   A   B "C1'" 1 
ATOM 6270 N N9    . A   B 2 5   ? 119.939 108.544 117.436 1.00 58.01  ? 5   A   B N9    1 
ATOM 6271 C C8    . A   B 2 5   ? 119.002 108.003 118.265 1.00 59.57  ? 5   A   B C8    1 
ATOM 6272 N N7    . A   B 2 5   ? 119.094 106.713 118.445 1.00 55.86  ? 5   A   B N7    1 
ATOM 6273 C C5    . A   B 2 5   ? 120.180 106.373 117.661 1.00 55.31  ? 5   A   B C5    1 
ATOM 6274 C C6    . A   B 2 5   ? 120.818 105.153 117.386 1.00 57.91  ? 5   A   B C6    1 
ATOM 6275 N N6    . A   B 2 5   ? 120.425 103.985 117.897 1.00 57.65  ? 5   A   B N6    1 
ATOM 6276 N N1    . A   B 2 5   ? 121.884 105.169 116.554 1.00 62.37  ? 5   A   B N1    1 
ATOM 6277 C C2    . A   B 2 5   ? 122.285 106.334 116.034 1.00 62.17  ? 5   A   B C2    1 
ATOM 6278 N N3    . A   B 2 5   ? 121.767 107.542 116.216 1.00 61.51  ? 5   A   B N3    1 
ATOM 6279 C C4    . A   B 2 5   ? 120.714 107.490 117.046 1.00 58.20  ? 5   A   B C4    1 
ATOM 6280 P P     . G   B 2 6   ? 116.883 112.565 114.578 1.00 82.91  ? 6   G   B P     1 
ATOM 6281 O OP1   . G   B 2 6   ? 116.357 113.951 114.640 1.00 63.48  ? 6   G   B OP1   1 
ATOM 6282 O OP2   . G   B 2 6   ? 116.064 111.424 115.056 1.00 71.12  ? 6   G   B OP2   1 
ATOM 6283 O "O5'" . G   B 2 6   ? 117.288 112.217 113.075 1.00 63.66  ? 6   G   B "O5'" 1 
ATOM 6284 C "C5'" . G   B 2 6   ? 118.646 112.258 112.654 1.00 61.19  ? 6   G   B "C5'" 1 
ATOM 6285 C "C4'" . G   B 2 6   ? 119.043 111.139 111.721 1.00 59.44  ? 6   G   B "C4'" 1 
ATOM 6286 O "O4'" . G   B 2 6   ? 119.417 109.936 112.466 1.00 57.60  ? 6   G   B "O4'" 1 
ATOM 6287 C "C3'" . G   B 2 6   ? 117.991 110.703 110.705 1.00 59.52  ? 6   G   B "C3'" 1 
ATOM 6288 O "O3'" . G   B 2 6   ? 118.659 110.334 109.488 1.00 74.75  ? 6   G   B "O3'" 1 
ATOM 6289 C "C2'" . G   B 2 6   ? 117.428 109.452 111.374 1.00 65.63  ? 6   G   B "C2'" 1 
ATOM 6290 O "O2'" . G   B 2 6   ? 116.696 108.579 110.547 1.00 76.90  ? 6   G   B "O2'" 1 
ATOM 6291 C "C1'" . G   B 2 6   ? 118.709 108.838 111.930 1.00 61.13  ? 6   G   B "C1'" 1 
ATOM 6292 N N9    . G   B 2 6   ? 118.506 107.792 112.939 1.00 60.08  ? 6   G   B N9    1 
ATOM 6293 C C8    . G   B 2 6   ? 117.582 107.803 113.953 1.00 65.65  ? 6   G   B C8    1 
ATOM 6294 N N7    . G   B 2 6   ? 117.606 106.723 114.680 1.00 70.86  ? 6   G   B N7    1 
ATOM 6295 C C5    . G   B 2 6   ? 118.595 105.937 114.103 1.00 71.32  ? 6   G   B C5    1 
ATOM 6296 C C6    . G   B 2 6   ? 119.061 104.648 114.473 1.00 68.66  ? 6   G   B C6    1 
ATOM 6297 O O6    . G   B 2 6   ? 118.672 103.943 115.408 1.00 62.63  ? 6   G   B O6    1 
ATOM 6298 N N1    . G   B 2 6   ? 120.073 104.197 113.637 1.00 64.95  ? 6   G   B N1    1 
ATOM 6299 C C2    . G   B 2 6   ? 120.578 104.899 112.575 1.00 64.32  ? 6   G   B C2    1 
ATOM 6300 N N2    . G   B 2 6   ? 121.554 104.277 111.895 1.00 62.32  ? 6   G   B N2    1 
ATOM 6301 N N3    . G   B 2 6   ? 120.151 106.107 112.218 1.00 62.36  ? 6   G   B N3    1 
ATOM 6302 C C4    . G   B 2 6   ? 119.160 106.572 113.019 1.00 64.15  ? 6   G   B C4    1 
ATOM 6303 P P     . A   B 2 7   ? 119.124 111.441 108.405 1.00 74.98  ? 7   A   B P     1 
ATOM 6304 O OP1   . A   B 2 7   ? 120.321 112.170 108.885 1.00 59.90  ? 7   A   B OP1   1 
ATOM 6305 O OP2   . A   B 2 7   ? 117.920 112.188 107.970 1.00 78.15  ? 7   A   B OP2   1 
ATOM 6306 O "O5'" . A   B 2 7   ? 119.683 110.591 107.177 1.00 79.50  ? 7   A   B "O5'" 1 
ATOM 6307 C "C5'" . A   B 2 7   ? 118.824 109.983 106.221 1.00 76.01  ? 7   A   B "C5'" 1 
ATOM 6308 C "C4'" . A   B 2 7   ? 119.411 108.680 105.742 1.00 73.69  ? 7   A   B "C4'" 1 
ATOM 6309 O "O4'" . A   B 2 7   ? 119.829 107.918 106.904 1.00 73.67  ? 7   A   B "O4'" 1 
ATOM 6310 C "C3'" . A   B 2 7   ? 118.471 107.753 104.980 1.00 70.38  ? 7   A   B "C3'" 1 
ATOM 6311 O "O3'" . A   B 2 7   ? 118.429 108.023 103.586 1.00 69.80  ? 7   A   B "O3'" 1 
ATOM 6312 C "C2'" . A   B 2 7   ? 119.007 106.363 105.315 1.00 73.90  ? 7   A   B "C2'" 1 
ATOM 6313 O "O2'" . A   B 2 7   ? 120.088 106.011 104.468 1.00 76.44  ? 7   A   B "O2'" 1 
ATOM 6314 C "C1'" . A   B 2 7   ? 119.531 106.554 106.736 1.00 67.19  ? 7   A   B "C1'" 1 
ATOM 6315 N N9    . A   B 2 7   ? 118.550 106.178 107.777 1.00 67.11  ? 7   A   B N9    1 
ATOM 6316 C C8    . A   B 2 7   ? 117.437 106.875 108.163 1.00 69.02  ? 7   A   B C8    1 
ATOM 6317 N N7    . A   B 2 7   ? 116.748 106.335 109.133 1.00 70.21  ? 7   A   B N7    1 
ATOM 6318 C C5    . A   B 2 7   ? 117.459 105.184 109.412 1.00 75.11  ? 7   A   B C5    1 
ATOM 6319 C C6    . A   B 2 7   ? 117.259 104.151 110.341 1.00 73.72  ? 7   A   B C6    1 
ATOM 6320 N N6    . A   B 2 7   ? 116.236 104.117 111.195 1.00 69.15  ? 7   A   B N6    1 
ATOM 6321 N N1    . A   B 2 7   ? 118.155 103.140 110.368 1.00 75.41  ? 7   A   B N1    1 
ATOM 6322 C C2    . A   B 2 7   ? 119.184 103.162 109.516 1.00 75.58  ? 7   A   B C2    1 
ATOM 6323 N N3    . A   B 2 7   ? 119.476 104.082 108.599 1.00 74.28  ? 7   A   B N3    1 
ATOM 6324 C C4    . A   B 2 7   ? 118.570 105.073 108.592 1.00 75.11  ? 7   A   B C4    1 
ATOM 6325 P P     . G   B 2 8   ? 117.028 108.228 102.816 1.00 90.45  ? 8   G   B P     1 
ATOM 6326 O OP1   . G   B 2 8   ? 117.085 109.567 102.181 1.00 92.06  ? 8   G   B OP1   1 
ATOM 6327 O OP2   . G   B 2 8   ? 115.910 107.945 103.747 1.00 89.52  ? 8   G   B OP2   1 
ATOM 6328 O "O5'" . G   B 2 8   ? 117.063 107.149 101.635 1.00 90.92  ? 8   G   B "O5'" 1 
ATOM 6329 C "C5'" . G   B 2 8   ? 116.169 106.037 101.588 1.00 91.02  ? 8   G   B "C5'" 1 
ATOM 6330 C "C4'" . G   B 2 8   ? 116.719 104.872 102.370 1.00 91.05  ? 8   G   B "C4'" 1 
ATOM 6331 O "O4'" . G   B 2 8   ? 116.470 105.117 103.768 1.00 95.77  ? 8   G   B "O4'" 1 
ATOM 6332 C "C3'" . G   B 2 8   ? 116.108 103.498 102.125 1.00 91.95  ? 8   G   B "C3'" 1 
ATOM 6333 O "O3'" . G   B 2 8   ? 116.668 102.834 101.001 1.00 94.61  ? 8   G   B "O3'" 1 
ATOM 6334 C "C2'" . G   B 2 8   ? 116.400 102.773 103.433 1.00 90.58  ? 8   G   B "C2'" 1 
ATOM 6335 O "O2'" . G   B 2 8   ? 117.724 102.264 103.437 1.00 87.95  ? 8   G   B "O2'" 1 
ATOM 6336 C "C1'" . G   B 2 8   ? 116.317 103.904 104.452 1.00 91.75  ? 8   G   B "C1'" 1 
ATOM 6337 N N9    . G   B 2 8   ? 115.044 103.942 105.185 1.00 92.00  ? 8   G   B N9    1 
ATOM 6338 C C8    . G   B 2 8   ? 113.973 104.780 104.995 1.00 92.64  ? 8   G   B C8    1 
ATOM 6339 N N7    . G   B 2 8   ? 113.001 104.558 105.836 1.00 92.77  ? 8   G   B N7    1 
ATOM 6340 C C5    . G   B 2 8   ? 113.474 103.523 106.628 1.00 94.19  ? 8   G   B C5    1 
ATOM 6341 C C6    . G   B 2 8   ? 112.875 102.846 107.713 1.00 91.48  ? 8   G   B C6    1 
ATOM 6342 O O6    . G   B 2 8   ? 111.769 103.008 108.242 1.00 91.34  ? 8   G   B O6    1 
ATOM 6343 N N1    . G   B 2 8   ? 113.727 101.870 108.207 1.00 89.99  ? 8   G   B N1    1 
ATOM 6344 C C2    . G   B 2 8   ? 114.981 101.570 107.743 1.00 90.75  ? 8   G   B C2    1 
ATOM 6345 N N2    . G   B 2 8   ? 115.595 100.569 108.381 1.00 91.20  ? 8   G   B N2    1 
ATOM 6346 N N3    . G   B 2 8   ? 115.547 102.185 106.730 1.00 91.88  ? 8   G   B N3    1 
ATOM 6347 C C4    . G   B 2 8   ? 114.737 103.139 106.237 1.00 93.35  ? 8   G   B C4    1 
ATOM 6348 P P     . C   B 2 9   ? 115.813 101.772 100.140 1.00 117.06 ? 9   C   B P     1 
ATOM 6349 O OP1   . C   B 2 9   ? 116.719 101.177 99.126  1.00 116.24 ? 9   C   B OP1   1 
ATOM 6350 O OP2   . C   B 2 9   ? 114.571 102.459 99.704  1.00 113.14 ? 9   C   B OP2   1 
ATOM 6351 O "O5'" . C   B 2 9   ? 115.402 100.615 101.164 1.00 112.47 ? 9   C   B "O5'" 1 
ATOM 6352 C "C5'" . C   B 2 9   ? 116.258 99.514  101.457 1.00 112.50 ? 9   C   B "C5'" 1 
ATOM 6353 C "C4'" . C   B 2 9   ? 115.904 98.893  102.790 1.00 113.66 ? 9   C   B "C4'" 1 
ATOM 6354 O "O4'" . C   B 2 9   ? 115.047 99.815  103.516 1.00 113.74 ? 9   C   B "O4'" 1 
ATOM 6355 C "C3'" . C   B 2 9   ? 115.105 97.594  102.748 1.00 115.22 ? 9   C   B "C3'" 1 
ATOM 6356 O "O3'" . C   B 2 9   ? 115.927 96.448  102.563 1.00 116.82 ? 9   C   B "O3'" 1 
ATOM 6357 C "C2'" . C   B 2 9   ? 114.359 97.617  104.081 1.00 115.22 ? 9   C   B "C2'" 1 
ATOM 6358 O "O2'" . C   B 2 9   ? 115.212 97.204  105.139 1.00 115.90 ? 9   C   B "O2'" 1 
ATOM 6359 C "C1'" . C   B 2 9   ? 114.072 99.110  104.249 1.00 114.49 ? 9   C   B "C1'" 1 
ATOM 6360 N N1    . C   B 2 9   ? 112.724 99.517  103.761 1.00 114.78 ? 9   C   B N1    1 
ATOM 6361 C C2    . C   B 2 9   ? 111.567 99.261  104.511 1.00 114.51 ? 9   C   B C2    1 
ATOM 6362 O O2    . C   B 2 9   ? 111.644 98.668  105.598 1.00 113.27 ? 9   C   B O2    1 
ATOM 6363 N N3    . C   B 2 9   ? 110.366 99.664  104.026 1.00 116.72 ? 9   C   B N3    1 
ATOM 6364 C C4    . C   B 2 9   ? 110.277 100.304 102.859 1.00 116.94 ? 9   C   B C4    1 
ATOM 6365 N N4    . C   B 2 9   ? 109.080 100.688 102.411 1.00 116.01 ? 9   C   B N4    1 
ATOM 6366 C C5    . C   B 2 9   ? 111.423 100.590 102.079 1.00 115.78 ? 9   C   B C5    1 
ATOM 6367 C C6    . C   B 2 9   ? 112.592 100.191 102.575 1.00 115.58 ? 9   C   B C6    1 
ATOM 6368 P P     . C   B 2 10  ? 115.322 94.951  102.565 1.00 127.26 ? 10  C   B P     1 
ATOM 6369 O OP1   . C   B 2 10  ? 115.340 94.434  103.957 1.00 120.21 ? 10  C   B OP1   1 
ATOM 6370 O OP2   . C   B 2 10  ? 116.032 94.177  101.519 1.00 123.69 ? 10  C   B OP2   1 
ATOM 6371 O "O5'" . C   B 2 10  ? 113.811 95.114  102.085 1.00 122.91 ? 10  C   B "O5'" 1 
ATOM 6372 C "C5'" . C   B 2 10  ? 113.233 94.215  101.146 1.00 118.99 ? 10  C   B "C5'" 1 
ATOM 6373 C "C4'" . C   B 2 10  ? 112.560 94.944  100.007 1.00 120.04 ? 10  C   B "C4'" 1 
ATOM 6374 O "O4'" . C   B 2 10  ? 111.161 95.181  100.327 1.00 120.24 ? 10  C   B "O4'" 1 
ATOM 6375 C "C3'" . C   B 2 10  ? 113.156 96.304  99.640  1.00 122.53 ? 10  C   B "C3'" 1 
ATOM 6376 O "O3'" . C   B 2 10  ? 113.139 96.458  98.226  1.00 124.60 ? 10  C   B "O3'" 1 
ATOM 6377 C "C2'" . C   B 2 10  ? 112.174 97.295  100.265 1.00 121.65 ? 10  C   B "C2'" 1 
ATOM 6378 O "O2'" . C   B 2 10  ? 112.126 98.555  99.627  1.00 118.78 ? 10  C   B "O2'" 1 
ATOM 6379 C "C1'" . C   B 2 10  ? 110.853 96.547  100.135 1.00 122.14 ? 10  C   B "C1'" 1 
ATOM 6380 N N1    . C   B 2 10  ? 109.846 96.941  101.129 1.00 123.51 ? 10  C   B N1    1 
ATOM 6381 C C2    . C   B 2 10  ? 108.899 97.899  100.769 1.00 123.30 ? 10  C   B C2    1 
ATOM 6382 O O2    . C   B 2 10  ? 108.945 98.386  99.630  1.00 124.64 ? 10  C   B O2    1 
ATOM 6383 N N3    . C   B 2 10  ? 107.965 98.276  101.671 1.00 119.95 ? 10  C   B N3    1 
ATOM 6384 C C4    . C   B 2 10  ? 107.952 97.726  102.885 1.00 118.18 ? 10  C   B C4    1 
ATOM 6385 N N4    . C   B 2 10  ? 107.010 98.133  103.736 1.00 117.08 ? 10  C   B N4    1 
ATOM 6386 C C5    . C   B 2 10  ? 108.906 96.745  103.279 1.00 120.01 ? 10  C   B C5    1 
ATOM 6387 C C6    . C   B 2 10  ? 109.827 96.384  102.377 1.00 121.12 ? 10  C   B C6    1 
ATOM 6388 P P     . G   C 3 1   ? 103.837 105.059 112.596 1.00 72.92  ? 10  G   C P     1 
ATOM 6389 O OP1   . G   C 3 1   ? 102.729 104.888 111.625 1.00 70.29  ? 10  G   C OP1   1 
ATOM 6390 O OP2   . G   C 3 1   ? 103.932 106.315 113.381 1.00 74.02  ? 10  G   C OP2   1 
ATOM 6391 O "O5'" . G   C 3 1   ? 103.763 103.831 113.606 1.00 74.17  ? 10  G   C "O5'" 1 
ATOM 6392 C "C5'" . G   C 3 1   ? 104.661 102.739 113.496 1.00 73.38  ? 10  G   C "C5'" 1 
ATOM 6393 C "C4'" . G   C 3 1   ? 104.002 101.552 112.844 1.00 74.07  ? 10  G   C "C4'" 1 
ATOM 6394 O "O4'" . G   C 3 1   ? 103.255 101.997 111.692 1.00 75.51  ? 10  G   C "O4'" 1 
ATOM 6395 C "C3'" . G   C 3 1   ? 104.953 100.489 112.312 1.00 77.45  ? 10  G   C "C3'" 1 
ATOM 6396 O "O3'" . G   C 3 1   ? 105.259 99.525  113.307 1.00 76.42  ? 10  G   C "O3'" 1 
ATOM 6397 C "C2'" . G   C 3 1   ? 104.206 99.885  111.122 1.00 76.87  ? 10  G   C "C2'" 1 
ATOM 6398 O "O2'" . G   C 3 1   ? 103.379 98.809  111.542 1.00 78.39  ? 10  G   C "O2'" 1 
ATOM 6399 C "C1'" . G   C 3 1   ? 103.306 101.035 110.669 1.00 79.13  ? 10  G   C "C1'" 1 
ATOM 6400 N N9    . G   C 3 1   ? 103.699 101.700 109.408 1.00 81.47  ? 10  G   C N9    1 
ATOM 6401 C C8    . G   C 3 1   ? 104.106 103.008 109.297 1.00 77.97  ? 10  G   C C8    1 
ATOM 6402 N N7    . G   C 3 1   ? 104.340 103.384 108.072 1.00 74.13  ? 10  G   C N7    1 
ATOM 6403 C C5    . G   C 3 1   ? 104.046 102.262 107.315 1.00 77.97  ? 10  G   C C5    1 
ATOM 6404 C C6    . G   C 3 1   ? 104.115 102.072 105.912 1.00 78.19  ? 10  G   C C6    1 
ATOM 6405 O O6    . G   C 3 1   ? 104.457 102.881 105.041 1.00 76.92  ? 10  G   C O6    1 
ATOM 6406 N N1    . G   C 3 1   ? 103.732 100.786 105.550 1.00 77.38  ? 10  G   C N1    1 
ATOM 6407 C C2    . G   C 3 1   ? 103.334 99.810  106.427 1.00 75.92  ? 10  G   C C2    1 
ATOM 6408 N N2    . G   C 3 1   ? 103.004 98.634  105.876 1.00 78.71  ? 10  G   C N2    1 
ATOM 6409 N N3    . G   C 3 1   ? 103.265 99.974  107.740 1.00 72.28  ? 10  G   C N3    1 
ATOM 6410 C C4    . G   C 3 1   ? 103.633 101.217 108.118 1.00 77.35  ? 10  G   C C4    1 
ATOM 6411 P P     . G   C 3 2   ? 106.741 99.382  113.904 1.00 95.90  ? 11  G   C P     1 
ATOM 6412 O OP1   . G   C 3 2   ? 106.631 98.899  115.300 1.00 89.03  ? 11  G   C OP1   1 
ATOM 6413 O OP2   . G   C 3 2   ? 107.481 100.640 113.639 1.00 86.71  ? 11  G   C OP2   1 
ATOM 6414 O "O5'" . G   C 3 2   ? 107.379 98.205  113.046 1.00 88.26  ? 11  G   C "O5'" 1 
ATOM 6415 C "C5'" . G   C 3 2   ? 106.583 97.136  112.552 1.00 86.16  ? 11  G   C "C5'" 1 
ATOM 6416 C "C4'" . G   C 3 2   ? 107.053 96.727  111.180 1.00 90.88  ? 11  G   C "C4'" 1 
ATOM 6417 O "O4'" . G   C 3 2   ? 106.551 97.697  110.226 1.00 91.21  ? 11  G   C "O4'" 1 
ATOM 6418 C "C3'" . G   C 3 2   ? 108.568 96.734  110.994 1.00 88.11  ? 11  G   C "C3'" 1 
ATOM 6419 O "O3'" . G   C 3 2   ? 109.185 95.495  111.318 1.00 87.40  ? 11  G   C "O3'" 1 
ATOM 6420 C "C2'" . G   C 3 2   ? 108.751 97.131  109.530 1.00 88.67  ? 11  G   C "C2'" 1 
ATOM 6421 O "O2'" . G   C 3 2   ? 108.642 95.996  108.684 1.00 87.29  ? 11  G   C "O2'" 1 
ATOM 6422 C "C1'" . G   C 3 2   ? 107.542 98.035  109.287 1.00 89.45  ? 11  G   C "C1'" 1 
ATOM 6423 N N9    . G   C 3 2   ? 107.843 99.476  109.434 1.00 85.92  ? 11  G   C N9    1 
ATOM 6424 C C8    . G   C 3 2   ? 108.079 100.170 110.594 1.00 86.15  ? 11  G   C C8    1 
ATOM 6425 N N7    . G   C 3 2   ? 108.308 101.439 110.424 1.00 84.85  ? 11  G   C N7    1 
ATOM 6426 C C5    . G   C 3 2   ? 108.193 101.610 109.057 1.00 84.97  ? 11  G   C C5    1 
ATOM 6427 C C6    . G   C 3 2   ? 108.329 102.784 108.279 1.00 87.10  ? 11  G   C C6    1 
ATOM 6428 O O6    . G   C 3 2   ? 108.585 103.932 108.658 1.00 89.51  ? 11  G   C O6    1 
ATOM 6429 N N1    . G   C 3 2   ? 108.137 102.522 106.930 1.00 84.67  ? 11  G   C N1    1 
ATOM 6430 C C2    . G   C 3 2   ? 107.850 101.288 106.403 1.00 85.76  ? 11  G   C C2    1 
ATOM 6431 N N2    . G   C 3 2   ? 107.696 101.241 105.075 1.00 89.19  ? 11  G   C N2    1 
ATOM 6432 N N3    . G   C 3 2   ? 107.720 100.183 107.118 1.00 86.11  ? 11  G   C N3    1 
ATOM 6433 C C4    . G   C 3 2   ? 107.906 100.414 108.431 1.00 83.80  ? 11  G   C C4    1 
ATOM 6434 P P     . C   C 3 3   ? 109.509 95.086  112.840 1.00 89.20  ? 12  C   C P     1 
ATOM 6435 O OP1   . C   C 3 3   ? 108.326 94.359  113.361 1.00 91.70  ? 12  C   C OP1   1 
ATOM 6436 O OP2   . C   C 3 3   ? 109.994 96.274  113.578 1.00 82.07  ? 12  C   C OP2   1 
ATOM 6437 O "O5'" . C   C 3 3   ? 110.700 94.039  112.711 1.00 91.32  ? 12  C   C "O5'" 1 
ATOM 6438 C "C5'" . C   C 3 3   ? 112.007 94.354  113.176 1.00 88.10  ? 12  C   C "C5'" 1 
ATOM 6439 C "C4'" . C   C 3 3   ? 112.969 94.542  112.031 1.00 90.07  ? 12  C   C "C4'" 1 
ATOM 6440 O "O4'" . C   C 3 3   ? 112.419 95.562  111.158 1.00 90.44  ? 12  C   C "O4'" 1 
ATOM 6441 C "C3'" . C   C 3 3   ? 114.363 95.017  112.446 1.00 94.09  ? 12  C   C "C3'" 1 
ATOM 6442 O "O3'" . C   C 3 3   ? 115.466 94.283  111.883 1.00 94.88  ? 12  C   C "O3'" 1 
ATOM 6443 C "C2'" . C   C 3 3   ? 114.415 96.483  112.015 1.00 93.89  ? 12  C   C "C2'" 1 
ATOM 6444 O "O2'" . C   C 3 3   ? 115.660 96.874  111.504 1.00 87.78  ? 12  C   C "O2'" 1 
ATOM 6445 C "C1'" . C   C 3 3   ? 113.378 96.568  110.909 1.00 92.89  ? 12  C   C "C1'" 1 
ATOM 6446 N N1    . C   C 3 3   ? 112.715 97.874  110.877 1.00 93.60  ? 12  C   C N1    1 
ATOM 6447 C C2    . C   C 3 3   ? 113.134 98.804  109.941 1.00 87.93  ? 12  C   C C2    1 
ATOM 6448 O O2    . C   C 3 3   ? 114.042 98.539  109.150 1.00 89.18  ? 12  C   C O2    1 
ATOM 6449 N N3    . C   C 3 3   ? 112.547 100.014 109.922 1.00 86.72  ? 12  C   C N3    1 
ATOM 6450 C C4    . C   C 3 3   ? 111.584 100.323 110.783 1.00 91.19  ? 12  C   C C4    1 
ATOM 6451 N N4    . C   C 3 3   ? 111.053 101.542 110.684 1.00 91.96  ? 12  C   C N4    1 
ATOM 6452 C C5    . C   C 3 3   ? 111.145 99.394  111.763 1.00 97.60  ? 12  C   C C5    1 
ATOM 6453 C C6    . C   C 3 3   ? 111.745 98.201  111.774 1.00 97.80  ? 12  C   C C6    1 
ATOM 6454 P P     . U   C 3 4   ? 115.496 93.515  110.463 1.00 98.09  ? 13  U   C P     1 
ATOM 6455 O OP1   . U   C 3 4   ? 114.742 94.104  109.332 1.00 94.18  ? 13  U   C OP1   1 
ATOM 6456 O OP2   . U   C 3 4   ? 115.325 92.078  110.775 1.00 92.16  ? 13  U   C OP2   1 
ATOM 6457 O "O5'" . U   C 3 4   ? 117.003 93.750  110.011 1.00 95.13  ? 13  U   C "O5'" 1 
ATOM 6458 C "C5'" . U   C 3 4   ? 117.386 94.998  109.440 1.00 95.14  ? 13  U   C "C5'" 1 
ATOM 6459 C "C4'" . U   C 3 4   ? 118.698 95.525  109.978 1.00 96.92  ? 13  U   C "C4'" 1 
ATOM 6460 O "O4'" . U   C 3 4   ? 118.600 96.968  110.160 1.00 95.65  ? 13  U   C "O4'" 1 
ATOM 6461 C "C3'" . U   C 3 4   ? 119.176 94.961  111.319 1.00 93.13  ? 13  U   C "C3'" 1 
ATOM 6462 O "O3'" . U   C 3 4   ? 120.601 94.881  111.290 1.00 95.69  ? 13  U   C "O3'" 1 
ATOM 6463 C "C2'" . U   C 3 4   ? 118.773 96.056  112.302 1.00 91.95  ? 13  U   C "C2'" 1 
ATOM 6464 O "O2'" . U   C 3 4   ? 119.507 96.054  113.508 1.00 94.77  ? 13  U   C "O2'" 1 
ATOM 6465 C "C1'" . U   C 3 4   ? 119.029 97.308  111.465 1.00 91.36  ? 13  U   C "C1'" 1 
ATOM 6466 N N1    . U   C 3 4   ? 118.334 98.533  111.919 1.00 93.12  ? 13  U   C N1    1 
ATOM 6467 C C2    . U   C 3 4   ? 118.432 99.689  111.152 1.00 92.41  ? 13  U   C C2    1 
ATOM 6468 O O2    . U   C 3 4   ? 119.027 99.775  110.092 1.00 92.05  ? 13  U   C O2    1 
ATOM 6469 N N3    . U   C 3 4   ? 117.766 100.776 111.658 1.00 91.18  ? 13  U   C N3    1 
ATOM 6470 C C4    . U   C 3 4   ? 117.048 100.868 112.828 1.00 92.89  ? 13  U   C C4    1 
ATOM 6471 O O4    . U   C 3 4   ? 116.513 101.932 113.138 1.00 91.54  ? 13  U   C O4    1 
ATOM 6472 C C5    . U   C 3 4   ? 117.006 99.658  113.580 1.00 96.37  ? 13  U   C C5    1 
ATOM 6473 C C6    . U   C 3 4   ? 117.648 98.584  113.118 1.00 95.66  ? 13  U   C C6    1 
ATOM 6474 P P     . C   C 3 5   ? 121.392 93.771  112.142 1.00 97.30  ? 14  C   C P     1 
ATOM 6475 O OP1   . C   C 3 5   ? 121.362 92.501  111.374 1.00 87.46  ? 14  C   C OP1   1 
ATOM 6476 O OP2   . C   C 3 5   ? 120.892 93.791  113.541 1.00 91.39  ? 14  C   C OP2   1 
ATOM 6477 O "O5'" . C   C 3 5   ? 122.896 94.303  112.153 1.00 96.12  ? 14  C   C "O5'" 1 
ATOM 6478 C "C5'" . C   C 3 5   ? 123.285 95.403  112.965 1.00 87.55  ? 14  C   C "C5'" 1 
ATOM 6479 C "C4'" . C   C 3 5   ? 123.551 96.638  112.138 1.00 85.85  ? 14  C   C "C4'" 1 
ATOM 6480 O "O4'" . C   C 3 5   ? 122.303 97.344  111.907 1.00 84.02  ? 14  C   C "O4'" 1 
ATOM 6481 C "C3'" . C   C 3 5   ? 124.453 97.687  112.771 1.00 89.02  ? 14  C   C "C3'" 1 
ATOM 6482 O "O3'" . C   C 3 5   ? 125.831 97.384  112.645 1.00 90.74  ? 14  C   C "O3'" 1 
ATOM 6483 C "C2'" . C   C 3 5   ? 124.032 98.968  112.055 1.00 89.24  ? 14  C   C "C2'" 1 
ATOM 6484 O "O2'" . C   C 3 5   ? 124.633 99.048  110.771 1.00 88.33  ? 14  C   C "O2'" 1 
ATOM 6485 C "C1'" . C   C 3 5   ? 122.531 98.739  111.871 1.00 87.74  ? 14  C   C "C1'" 1 
ATOM 6486 N N1    . C   C 3 5   ? 121.701 99.397  112.918 1.00 89.53  ? 14  C   C N1    1 
ATOM 6487 C C2    . C   C 3 5   ? 121.333 100.747 112.792 1.00 90.88  ? 14  C   C C2    1 
ATOM 6488 O O2    . C   C 3 5   ? 121.712 101.412 111.815 1.00 89.75  ? 14  C   C O2    1 
ATOM 6489 N N3    . C   C 3 5   ? 120.565 101.316 113.758 1.00 89.50  ? 14  C   C N3    1 
ATOM 6490 C C4    . C   C 3 5   ? 120.156 100.607 114.807 1.00 89.36  ? 14  C   C C4    1 
ATOM 6491 N N4    . C   C 3 5   ? 119.407 101.196 115.740 1.00 86.72  ? 14  C   C N4    1 
ATOM 6492 C C5    . C   C 3 5   ? 120.510 99.244  114.969 1.00 91.12  ? 14  C   C C5    1 
ATOM 6493 C C6    . C   C 3 5   ? 121.257 98.696  114.010 1.00 92.00  ? 14  C   C C6    1 
ATOM 6494 P P     . U   C 3 6   ? 126.782 97.386  113.941 1.00 93.16  ? 15  U   C P     1 
ATOM 6495 O OP1   . U   C 3 6   ? 127.946 96.506  113.666 1.00 84.40  ? 15  U   C OP1   1 
ATOM 6496 O OP2   . U   C 3 6   ? 125.938 97.130  115.135 1.00 90.13  ? 15  U   C OP2   1 
ATOM 6497 O "O5'" . U   C 3 6   ? 127.308 98.886  114.027 1.00 83.44  ? 15  U   C "O5'" 1 
ATOM 6498 C "C5'" . U   C 3 6   ? 128.019 99.470  112.946 1.00 80.92  ? 15  U   C "C5'" 1 
ATOM 6499 C "C4'" . U   C 3 6   ? 127.952 100.975 112.994 1.00 84.18  ? 15  U   C "C4'" 1 
ATOM 6500 O "O4'" . U   C 3 6   ? 126.578 101.409 112.818 1.00 84.32  ? 15  U   C "O4'" 1 
ATOM 6501 C "C3'" . U   C 3 6   ? 128.372 101.614 114.308 1.00 83.26  ? 15  U   C "C3'" 1 
ATOM 6502 O "O3'" . U   C 3 6   ? 129.777 101.741 114.441 1.00 85.61  ? 15  U   C "O3'" 1 
ATOM 6503 C "C2'" . U   C 3 6   ? 127.640 102.949 114.282 1.00 78.02  ? 15  U   C "C2'" 1 
ATOM 6504 O "O2'" . U   C 3 6   ? 128.331 103.885 113.470 1.00 78.65  ? 15  U   C "O2'" 1 
ATOM 6505 C "C1'" . U   C 3 6   ? 126.337 102.573 113.579 1.00 77.33  ? 15  U   C "C1'" 1 
ATOM 6506 N N1    . U   C 3 6   ? 125.212 102.315 114.512 1.00 78.32  ? 15  U   C N1    1 
ATOM 6507 C C2    . U   C 3 6   ? 124.504 103.388 115.015 1.00 82.69  ? 15  U   C C2    1 
ATOM 6508 O O2    . U   C 3 6   ? 124.767 104.546 114.764 1.00 85.34  ? 15  U   C O2    1 
ATOM 6509 N N3    . U   C 3 6   ? 123.463 103.069 115.849 1.00 84.01  ? 15  U   C N3    1 
ATOM 6510 C C4    . U   C 3 6   ? 123.045 101.813 116.227 1.00 84.27  ? 15  U   C C4    1 
ATOM 6511 O O4    . U   C 3 6   ? 122.087 101.685 116.991 1.00 87.35  ? 15  U   C O4    1 
ATOM 6512 C C5    . U   C 3 6   ? 123.814 100.750 115.664 1.00 82.95  ? 15  U   C C5    1 
ATOM 6513 C C6    . U   C 3 6   ? 124.836 101.037 114.853 1.00 82.02  ? 15  U   C C6    1 
ATOM 6514 P P     . U   C 3 7   ? 130.461 101.648 115.892 1.00 76.56  ? 16  U   C P     1 
ATOM 6515 O OP1   . U   C 3 7   ? 131.927 101.523 115.693 1.00 73.80  ? 16  U   C OP1   1 
ATOM 6516 O OP2   . U   C 3 7   ? 129.733 100.619 116.678 1.00 74.56  ? 16  U   C OP2   1 
ATOM 6517 O "O5'" . U   C 3 7   ? 130.166 103.067 116.554 1.00 75.04  ? 16  U   C "O5'" 1 
ATOM 6518 C "C5'" . U   C 3 7   ? 130.689 104.260 115.988 1.00 75.65  ? 16  U   C "C5'" 1 
ATOM 6519 C "C4'" . U   C 3 7   ? 130.009 105.484 116.548 1.00 75.98  ? 16  U   C "C4'" 1 
ATOM 6520 O "O4'" . U   C 3 7   ? 128.589 105.432 116.260 1.00 76.31  ? 16  U   C "O4'" 1 
ATOM 6521 C "C3'" . U   C 3 7   ? 130.071 105.645 118.057 1.00 73.72  ? 16  U   C "C3'" 1 
ATOM 6522 O "O3'" . U   C 3 7   ? 131.300 106.195 118.502 1.00 73.03  ? 16  U   C "O3'" 1 
ATOM 6523 C "C2'" . U   C 3 7   ? 128.864 106.527 118.351 1.00 70.45  ? 16  U   C "C2'" 1 
ATOM 6524 O "O2'" . U   C 3 7   ? 129.163 107.886 118.073 1.00 78.40  ? 16  U   C "O2'" 1 
ATOM 6525 C "C1'" . U   C 3 7   ? 127.862 106.038 117.306 1.00 73.43  ? 16  U   C "C1'" 1 
ATOM 6526 N N1    . U   C 3 7   ? 126.861 105.076 117.834 1.00 76.80  ? 16  U   C N1    1 
ATOM 6527 C C2    . U   C 3 7   ? 125.713 105.598 118.402 1.00 72.94  ? 16  U   C C2    1 
ATOM 6528 O O2    . U   C 3 7   ? 125.528 106.794 118.502 1.00 70.41  ? 16  U   C O2    1 
ATOM 6529 N N3    . U   C 3 7   ? 124.792 104.682 118.858 1.00 72.36  ? 16  U   C N3    1 
ATOM 6530 C C4    . U   C 3 7   ? 124.904 103.308 118.795 1.00 70.57  ? 16  U   C C4    1 
ATOM 6531 O O4    . U   C 3 7   ? 124.007 102.592 119.242 1.00 72.66  ? 16  U   C O4    1 
ATOM 6532 C C5    . U   C 3 7   ? 126.110 102.838 118.189 1.00 74.36  ? 16  U   C C5    1 
ATOM 6533 C C6    . U   C 3 7   ? 127.018 103.712 117.741 1.00 78.74  ? 16  U   C C6    1 
ATOM 6534 P P     . G   C 3 8   ? 131.715 106.104 120.052 1.00 76.97  ? 17  G   C P     1 
ATOM 6535 O OP1   . G   C 3 8   ? 133.190 106.239 120.140 1.00 72.99  ? 17  G   C OP1   1 
ATOM 6536 O OP2   . G   C 3 8   ? 131.051 104.912 120.637 1.00 75.86  ? 17  G   C OP2   1 
ATOM 6537 O "O5'" . G   C 3 8   ? 131.062 107.405 120.700 1.00 74.13  ? 17  G   C "O5'" 1 
ATOM 6538 C "C5'" . G   C 3 8   ? 130.633 107.416 122.053 1.00 70.78  ? 17  G   C "C5'" 1 
ATOM 6539 C "C4'" . G   C 3 8   ? 129.273 108.054 122.187 1.00 70.70  ? 17  G   C "C4'" 1 
ATOM 6540 O "O4'" . G   C 3 8   ? 128.286 107.226 121.530 1.00 65.38  ? 17  G   C "O4'" 1 
ATOM 6541 C "C3'" . G   C 3 8   ? 128.740 108.223 123.602 1.00 74.87  ? 17  G   C "C3'" 1 
ATOM 6542 O "O3'" . G   C 3 8   ? 129.214 109.410 124.218 1.00 76.57  ? 17  G   C "O3'" 1 
ATOM 6543 C "C2'" . G   C 3 8   ? 127.225 108.247 123.407 1.00 74.02  ? 17  G   C "C2'" 1 
ATOM 6544 O "O2'" . G   C 3 8   ? 126.778 109.566 123.127 1.00 78.61  ? 17  G   C "O2'" 1 
ATOM 6545 C "C1'" . G   C 3 8   ? 127.033 107.389 122.148 1.00 69.77  ? 17  G   C "C1'" 1 
ATOM 6546 N N9    . G   C 3 8   ? 126.417 106.065 122.390 1.00 75.47  ? 17  G   C N9    1 
ATOM 6547 C C8    . G   C 3 8   ? 126.973 104.846 122.087 1.00 78.90  ? 17  G   C C8    1 
ATOM 6548 N N7    . G   C 3 8   ? 126.200 103.836 122.381 1.00 75.05  ? 17  G   C N7    1 
ATOM 6549 C C5    . G   C 3 8   ? 125.048 104.415 122.893 1.00 69.77  ? 17  G   C C5    1 
ATOM 6550 C C6    . G   C 3 8   ? 123.854 103.818 123.378 1.00 66.57  ? 17  G   C C6    1 
ATOM 6551 O O6    . G   C 3 8   ? 123.558 102.619 123.458 1.00 68.44  ? 17  G   C O6    1 
ATOM 6552 N N1    . G   C 3 8   ? 122.937 104.771 123.804 1.00 67.40  ? 17  G   C N1    1 
ATOM 6553 C C2    . G   C 3 8   ? 123.136 106.127 123.757 1.00 65.06  ? 17  G   C C2    1 
ATOM 6554 N N2    . G   C 3 8   ? 122.155 106.910 124.219 1.00 67.41  ? 17  G   C N2    1 
ATOM 6555 N N3    . G   C 3 8   ? 124.243 106.690 123.313 1.00 64.78  ? 17  G   C N3    1 
ATOM 6556 C C4    . G   C 3 8   ? 125.159 105.790 122.894 1.00 68.74  ? 17  G   C C4    1 
ATOM 6557 P P     . U   C 3 9   ? 130.558 109.423 125.100 1.00 81.07  ? 18  U   C P     1 
ATOM 6558 O OP1   . U   C 3 9   ? 131.654 109.883 124.210 1.00 71.48  ? 18  U   C OP1   1 
ATOM 6559 O OP2   . U   C 3 9   ? 130.696 108.119 125.792 1.00 78.67  ? 18  U   C OP2   1 
ATOM 6560 O "O5'" . U   C 3 9   ? 130.298 110.571 126.178 1.00 78.60  ? 18  U   C "O5'" 1 
ATOM 6561 C "C5'" . U   C 3 9   ? 129.575 110.315 127.380 1.00 75.06  ? 18  U   C "C5'" 1 
ATOM 6562 C "C4'" . U   C 3 9   ? 128.115 110.679 127.250 1.00 74.37  ? 18  U   C "C4'" 1 
ATOM 6563 O "O4'" . U   C 3 9   ? 127.427 109.610 126.546 1.00 65.10  ? 18  U   C "O4'" 1 
ATOM 6564 C "C3'" . U   C 3 9   ? 127.368 110.869 128.569 1.00 74.26  ? 18  U   C "C3'" 1 
ATOM 6565 O "O3'" . U   C 3 9   ? 126.353 111.859 128.404 1.00 76.62  ? 18  U   C "O3'" 1 
ATOM 6566 C "C2'" . U   C 3 9   ? 126.715 109.510 128.788 1.00 73.26  ? 18  U   C "C2'" 1 
ATOM 6567 O "O2'" . U   C 3 9   ? 125.559 109.542 129.597 1.00 69.47  ? 18  U   C "O2'" 1 
ATOM 6568 C "C1'" . U   C 3 9   ? 126.390 109.090 127.356 1.00 70.92  ? 18  U   C "C1'" 1 
ATOM 6569 N N1    . U   C 3 9   ? 126.306 107.631 127.142 1.00 78.57  ? 18  U   C N1    1 
ATOM 6570 C C2    . U   C 3 9   ? 127.420 106.793 127.220 1.00 78.91  ? 18  U   C C2    1 
ATOM 6571 O O2    . U   C 3 9   ? 128.559 107.138 127.474 1.00 75.83  ? 18  U   C O2    1 
ATOM 6572 N N3    . U   C 3 9   ? 127.164 105.464 126.988 1.00 75.82  ? 18  U   C N3    1 
ATOM 6573 C C4    . U   C 3 9   ? 125.954 104.879 126.690 1.00 68.85  ? 18  U   C C4    1 
ATOM 6574 O O4    . U   C 3 9   ? 125.886 103.663 126.509 1.00 66.96  ? 18  U   C O4    1 
ATOM 6575 C C5    . U   C 3 9   ? 124.866 105.796 126.630 1.00 70.82  ? 18  U   C C5    1 
ATOM 6576 C C6    . U   C 3 9   ? 125.075 107.098 126.845 1.00 75.46  ? 18  U   C C6    1 
# 
