data_9JQL
# 
_entry.id   9JQL 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9JQL         pdb_00009jql 10.2210/pdb9jql/pdb 
WWPDB D_1300051924 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-06-11 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9JQL 
_pdbx_database_status.recvd_initial_deposition_date   2024-09-27 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              xiewei6@mail.sysu.edu.cn 
_pdbx_contact_author.name_first         Wei 
_pdbx_contact_author.name_last          Xie 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-2410-2135 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Xie, W.' 1 0000-0003-2410-2135 
'Jia, Q.' 2 0000-0002-1629-6622 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Biochem.J. 
_citation.journal_id_ASTM           BIJOAK 
_citation.journal_id_CSD            0043 
_citation.journal_id_ISSN           1470-8728 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            482 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'The C-terminal structure of the N6-methyladenosine deaminase YerA and its role in deamination.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1042/BCJ20240728 
_citation.pdbx_database_id_PubMed   39876819 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Jia, Q.'  1 0000-0002-1629-6622 
primary 'Zeng, H.' 2 ?                   
primary 'Xiao, N.' 3 ?                   
primary 'Tang, J.' 4 ?                   
primary 'Gao, S.'  5 ?                   
primary 'Xie, W.'  6 0000-0003-2410-2135 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'Putative adenine deaminase YerA' 22717.412 1  3.5.4.2 ? ? ? 
2 water   nat water                             18.015    99 ?       ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Adenase,Adenine aminase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GGLVPLELSYDMTMDDLQFSMPMGVKMRNAVIMEPYMIEIDNSMEQLSFDHDESYLTMLDRHGKWRVNTMIKGFASSVQG
FVSSFTTTGDIVAIGKNKADMLLAFARMKEIGGGIVLAENGNILHEIPLALCGCASSEAYEDVLEKEQKLRDLLTERGYE
FCDPIYTLLFLQSTHLPYIRITPRGIFDVMKKTVLFPSIMR
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GGLVPLELSYDMTMDDLQFSMPMGVKMRNAVIMEPYMIEIDNSMEQLSFDHDESYLTMLDRHGKWRVNTMIKGFASSVQG
FVSSFTTTGDIVAIGKNKADMLLAFARMKEIGGGIVLAENGNILHEIPLALCGCASSEAYEDVLEKEQKLRDLLTERGYE
FCDPIYTLLFLQSTHLPYIRITPRGIFDVMKKTVLFPSIMR
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   GLY n 
1 3   LEU n 
1 4   VAL n 
1 5   PRO n 
1 6   LEU n 
1 7   GLU n 
1 8   LEU n 
1 9   SER n 
1 10  TYR n 
1 11  ASP n 
1 12  MET n 
1 13  THR n 
1 14  MET n 
1 15  ASP n 
1 16  ASP n 
1 17  LEU n 
1 18  GLN n 
1 19  PHE n 
1 20  SER n 
1 21  MET n 
1 22  PRO n 
1 23  MET n 
1 24  GLY n 
1 25  VAL n 
1 26  LYS n 
1 27  MET n 
1 28  ARG n 
1 29  ASN n 
1 30  ALA n 
1 31  VAL n 
1 32  ILE n 
1 33  MET n 
1 34  GLU n 
1 35  PRO n 
1 36  TYR n 
1 37  MET n 
1 38  ILE n 
1 39  GLU n 
1 40  ILE n 
1 41  ASP n 
1 42  ASN n 
1 43  SER n 
1 44  MET n 
1 45  GLU n 
1 46  GLN n 
1 47  LEU n 
1 48  SER n 
1 49  PHE n 
1 50  ASP n 
1 51  HIS n 
1 52  ASP n 
1 53  GLU n 
1 54  SER n 
1 55  TYR n 
1 56  LEU n 
1 57  THR n 
1 58  MET n 
1 59  LEU n 
1 60  ASP n 
1 61  ARG n 
1 62  HIS n 
1 63  GLY n 
1 64  LYS n 
1 65  TRP n 
1 66  ARG n 
1 67  VAL n 
1 68  ASN n 
1 69  THR n 
1 70  MET n 
1 71  ILE n 
1 72  LYS n 
1 73  GLY n 
1 74  PHE n 
1 75  ALA n 
1 76  SER n 
1 77  SER n 
1 78  VAL n 
1 79  GLN n 
1 80  GLY n 
1 81  PHE n 
1 82  VAL n 
1 83  SER n 
1 84  SER n 
1 85  PHE n 
1 86  THR n 
1 87  THR n 
1 88  THR n 
1 89  GLY n 
1 90  ASP n 
1 91  ILE n 
1 92  VAL n 
1 93  ALA n 
1 94  ILE n 
1 95  GLY n 
1 96  LYS n 
1 97  ASN n 
1 98  LYS n 
1 99  ALA n 
1 100 ASP n 
1 101 MET n 
1 102 LEU n 
1 103 LEU n 
1 104 ALA n 
1 105 PHE n 
1 106 ALA n 
1 107 ARG n 
1 108 MET n 
1 109 LYS n 
1 110 GLU n 
1 111 ILE n 
1 112 GLY n 
1 113 GLY n 
1 114 GLY n 
1 115 ILE n 
1 116 VAL n 
1 117 LEU n 
1 118 ALA n 
1 119 GLU n 
1 120 ASN n 
1 121 GLY n 
1 122 ASN n 
1 123 ILE n 
1 124 LEU n 
1 125 HIS n 
1 126 GLU n 
1 127 ILE n 
1 128 PRO n 
1 129 LEU n 
1 130 ALA n 
1 131 LEU n 
1 132 CYS n 
1 133 GLY n 
1 134 CYS n 
1 135 ALA n 
1 136 SER n 
1 137 SER n 
1 138 GLU n 
1 139 ALA n 
1 140 TYR n 
1 141 GLU n 
1 142 ASP n 
1 143 VAL n 
1 144 LEU n 
1 145 GLU n 
1 146 LYS n 
1 147 GLU n 
1 148 GLN n 
1 149 LYS n 
1 150 LEU n 
1 151 ARG n 
1 152 ASP n 
1 153 LEU n 
1 154 LEU n 
1 155 THR n 
1 156 GLU n 
1 157 ARG n 
1 158 GLY n 
1 159 TYR n 
1 160 GLU n 
1 161 PHE n 
1 162 CYS n 
1 163 ASP n 
1 164 PRO n 
1 165 ILE n 
1 166 TYR n 
1 167 THR n 
1 168 LEU n 
1 169 LEU n 
1 170 PHE n 
1 171 LEU n 
1 172 GLN n 
1 173 SER n 
1 174 THR n 
1 175 HIS n 
1 176 LEU n 
1 177 PRO n 
1 178 TYR n 
1 179 ILE n 
1 180 ARG n 
1 181 ILE n 
1 182 THR n 
1 183 PRO n 
1 184 ARG n 
1 185 GLY n 
1 186 ILE n 
1 187 PHE n 
1 188 ASP n 
1 189 VAL n 
1 190 MET n 
1 191 LYS n 
1 192 LYS n 
1 193 THR n 
1 194 VAL n 
1 195 LEU n 
1 196 PHE n 
1 197 PRO n 
1 198 SER n 
1 199 ILE n 
1 200 MET n 
1 201 ARG n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   201 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'yerA, yecB, BSU06560' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    168 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Bacillus subtilis' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     224308 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   380 380 GLY GLY A . n 
A 1 2   GLY 2   381 381 GLY GLY A . n 
A 1 3   LEU 3   382 382 LEU LEU A . n 
A 1 4   VAL 4   383 383 VAL VAL A . n 
A 1 5   PRO 5   384 384 PRO PRO A . n 
A 1 6   LEU 6   385 385 LEU LEU A . n 
A 1 7   GLU 7   386 386 GLU GLU A . n 
A 1 8   LEU 8   387 387 LEU LEU A . n 
A 1 9   SER 9   388 388 SER SER A . n 
A 1 10  TYR 10  389 389 TYR TYR A . n 
A 1 11  ASP 11  390 390 ASP ASP A . n 
A 1 12  MET 12  391 391 MET MET A . n 
A 1 13  THR 13  392 392 THR THR A . n 
A 1 14  MET 14  393 393 MET MET A . n 
A 1 15  ASP 15  394 394 ASP ASP A . n 
A 1 16  ASP 16  395 395 ASP ASP A . n 
A 1 17  LEU 17  396 396 LEU LEU A . n 
A 1 18  GLN 18  397 397 GLN GLN A . n 
A 1 19  PHE 19  398 398 PHE PHE A . n 
A 1 20  SER 20  399 399 SER SER A . n 
A 1 21  MET 21  400 400 MET MET A . n 
A 1 22  PRO 22  401 401 PRO PRO A . n 
A 1 23  MET 23  402 402 MET MET A . n 
A 1 24  GLY 24  403 403 GLY GLY A . n 
A 1 25  VAL 25  404 404 VAL VAL A . n 
A 1 26  LYS 26  405 405 LYS LYS A . n 
A 1 27  MET 27  406 406 MET MET A . n 
A 1 28  ARG 28  407 407 ARG ARG A . n 
A 1 29  ASN 29  408 408 ASN ASN A . n 
A 1 30  ALA 30  409 409 ALA ALA A . n 
A 1 31  VAL 31  410 410 VAL VAL A . n 
A 1 32  ILE 32  411 411 ILE ILE A . n 
A 1 33  MET 33  412 412 MET MET A . n 
A 1 34  GLU 34  413 413 GLU GLU A . n 
A 1 35  PRO 35  414 414 PRO PRO A . n 
A 1 36  TYR 36  415 415 TYR TYR A . n 
A 1 37  MET 37  416 416 MET MET A . n 
A 1 38  ILE 38  417 417 ILE ILE A . n 
A 1 39  GLU 39  418 418 GLU GLU A . n 
A 1 40  ILE 40  419 419 ILE ILE A . n 
A 1 41  ASP 41  420 420 ASP ASP A . n 
A 1 42  ASN 42  421 421 ASN ASN A . n 
A 1 43  SER 43  422 422 SER SER A . n 
A 1 44  MET 44  423 423 MET MET A . n 
A 1 45  GLU 45  424 424 GLU GLU A . n 
A 1 46  GLN 46  425 425 GLN GLN A . n 
A 1 47  LEU 47  426 426 LEU LEU A . n 
A 1 48  SER 48  427 427 SER SER A . n 
A 1 49  PHE 49  428 428 PHE PHE A . n 
A 1 50  ASP 50  429 429 ASP ASP A . n 
A 1 51  HIS 51  430 430 HIS HIS A . n 
A 1 52  ASP 52  431 431 ASP ASP A . n 
A 1 53  GLU 53  432 432 GLU GLU A . n 
A 1 54  SER 54  433 433 SER SER A . n 
A 1 55  TYR 55  434 434 TYR TYR A . n 
A 1 56  LEU 56  435 435 LEU LEU A . n 
A 1 57  THR 57  436 436 THR THR A . n 
A 1 58  MET 58  437 437 MET MET A . n 
A 1 59  LEU 59  438 438 LEU LEU A . n 
A 1 60  ASP 60  439 439 ASP ASP A . n 
A 1 61  ARG 61  440 440 ARG ARG A . n 
A 1 62  HIS 62  441 441 HIS HIS A . n 
A 1 63  GLY 63  442 442 GLY GLY A . n 
A 1 64  LYS 64  443 443 LYS LYS A . n 
A 1 65  TRP 65  444 444 TRP TRP A . n 
A 1 66  ARG 66  445 445 ARG ARG A . n 
A 1 67  VAL 67  446 446 VAL VAL A . n 
A 1 68  ASN 68  447 447 ASN ASN A . n 
A 1 69  THR 69  448 448 THR THR A . n 
A 1 70  MET 70  449 449 MET MET A . n 
A 1 71  ILE 71  450 450 ILE ILE A . n 
A 1 72  LYS 72  451 451 LYS LYS A . n 
A 1 73  GLY 73  452 452 GLY GLY A . n 
A 1 74  PHE 74  453 453 PHE PHE A . n 
A 1 75  ALA 75  454 454 ALA ALA A . n 
A 1 76  SER 76  455 455 SER SER A . n 
A 1 77  SER 77  456 456 SER SER A . n 
A 1 78  VAL 78  457 457 VAL VAL A . n 
A 1 79  GLN 79  458 458 GLN GLN A . n 
A 1 80  GLY 80  459 459 GLY GLY A . n 
A 1 81  PHE 81  460 460 PHE PHE A . n 
A 1 82  VAL 82  461 461 VAL VAL A . n 
A 1 83  SER 83  462 462 SER SER A . n 
A 1 84  SER 84  463 463 SER SER A . n 
A 1 85  PHE 85  464 464 PHE PHE A . n 
A 1 86  THR 86  465 465 THR THR A . n 
A 1 87  THR 87  466 466 THR THR A . n 
A 1 88  THR 88  467 467 THR THR A . n 
A 1 89  GLY 89  468 468 GLY GLY A . n 
A 1 90  ASP 90  469 469 ASP ASP A . n 
A 1 91  ILE 91  470 470 ILE ILE A . n 
A 1 92  VAL 92  471 471 VAL VAL A . n 
A 1 93  ALA 93  472 472 ALA ALA A . n 
A 1 94  ILE 94  473 473 ILE ILE A . n 
A 1 95  GLY 95  474 474 GLY GLY A . n 
A 1 96  LYS 96  475 475 LYS LYS A . n 
A 1 97  ASN 97  476 476 ASN ASN A . n 
A 1 98  LYS 98  477 477 LYS LYS A . n 
A 1 99  ALA 99  478 478 ALA ALA A . n 
A 1 100 ASP 100 479 479 ASP ASP A . n 
A 1 101 MET 101 480 480 MET MET A . n 
A 1 102 LEU 102 481 481 LEU LEU A . n 
A 1 103 LEU 103 482 482 LEU LEU A . n 
A 1 104 ALA 104 483 483 ALA ALA A . n 
A 1 105 PHE 105 484 484 PHE PHE A . n 
A 1 106 ALA 106 485 485 ALA ALA A . n 
A 1 107 ARG 107 486 486 ARG ARG A . n 
A 1 108 MET 108 487 487 MET MET A . n 
A 1 109 LYS 109 488 488 LYS LYS A . n 
A 1 110 GLU 110 489 489 GLU GLU A . n 
A 1 111 ILE 111 490 490 ILE ILE A . n 
A 1 112 GLY 112 491 491 GLY GLY A . n 
A 1 113 GLY 113 492 492 GLY GLY A . n 
A 1 114 GLY 114 493 493 GLY GLY A . n 
A 1 115 ILE 115 494 494 ILE ILE A . n 
A 1 116 VAL 116 495 495 VAL VAL A . n 
A 1 117 LEU 117 496 496 LEU LEU A . n 
A 1 118 ALA 118 497 497 ALA ALA A . n 
A 1 119 GLU 119 498 498 GLU GLU A . n 
A 1 120 ASN 120 499 499 ASN ASN A . n 
A 1 121 GLY 121 500 500 GLY GLY A . n 
A 1 122 ASN 122 501 501 ASN ASN A . n 
A 1 123 ILE 123 502 502 ILE ILE A . n 
A 1 124 LEU 124 503 503 LEU LEU A . n 
A 1 125 HIS 125 504 504 HIS HIS A . n 
A 1 126 GLU 126 505 505 GLU GLU A . n 
A 1 127 ILE 127 506 506 ILE ILE A . n 
A 1 128 PRO 128 507 507 PRO PRO A . n 
A 1 129 LEU 129 508 508 LEU LEU A . n 
A 1 130 ALA 130 509 509 ALA ALA A . n 
A 1 131 LEU 131 510 510 LEU LEU A . n 
A 1 132 CYS 132 511 511 CYS CYS A . n 
A 1 133 GLY 133 512 512 GLY GLY A . n 
A 1 134 CYS 134 513 513 CYS CYS A . n 
A 1 135 ALA 135 514 514 ALA ALA A . n 
A 1 136 SER 136 515 515 SER SER A . n 
A 1 137 SER 137 516 516 SER SER A . n 
A 1 138 GLU 138 517 517 GLU GLU A . n 
A 1 139 ALA 139 518 518 ALA ALA A . n 
A 1 140 TYR 140 519 519 TYR TYR A . n 
A 1 141 GLU 141 520 520 GLU GLU A . n 
A 1 142 ASP 142 521 521 ASP ASP A . n 
A 1 143 VAL 143 522 522 VAL VAL A . n 
A 1 144 LEU 144 523 523 LEU LEU A . n 
A 1 145 GLU 145 524 524 GLU GLU A . n 
A 1 146 LYS 146 525 525 LYS LYS A . n 
A 1 147 GLU 147 526 526 GLU GLU A . n 
A 1 148 GLN 148 527 527 GLN GLN A . n 
A 1 149 LYS 149 528 528 LYS LYS A . n 
A 1 150 LEU 150 529 529 LEU LEU A . n 
A 1 151 ARG 151 530 530 ARG ARG A . n 
A 1 152 ASP 152 531 531 ASP ASP A . n 
A 1 153 LEU 153 532 532 LEU LEU A . n 
A 1 154 LEU 154 533 533 LEU LEU A . n 
A 1 155 THR 155 534 534 THR THR A . n 
A 1 156 GLU 156 535 535 GLU GLU A . n 
A 1 157 ARG 157 536 536 ARG ARG A . n 
A 1 158 GLY 158 537 537 GLY GLY A . n 
A 1 159 TYR 159 538 538 TYR TYR A . n 
A 1 160 GLU 160 539 539 GLU GLU A . n 
A 1 161 PHE 161 540 540 PHE PHE A . n 
A 1 162 CYS 162 541 541 CYS CYS A . n 
A 1 163 ASP 163 542 542 ASP ASP A . n 
A 1 164 PRO 164 543 543 PRO PRO A . n 
A 1 165 ILE 165 544 544 ILE ILE A . n 
A 1 166 TYR 166 545 545 TYR TYR A . n 
A 1 167 THR 167 546 546 THR THR A . n 
A 1 168 LEU 168 547 547 LEU LEU A . n 
A 1 169 LEU 169 548 548 LEU LEU A . n 
A 1 170 PHE 170 549 549 PHE PHE A . n 
A 1 171 LEU 171 550 550 LEU LEU A . n 
A 1 172 GLN 172 551 551 GLN GLN A . n 
A 1 173 SER 173 552 552 SER SER A . n 
A 1 174 THR 174 553 553 THR THR A . n 
A 1 175 HIS 175 554 554 HIS HIS A . n 
A 1 176 LEU 176 555 555 LEU LEU A . n 
A 1 177 PRO 177 556 556 PRO PRO A . n 
A 1 178 TYR 178 557 557 TYR TYR A . n 
A 1 179 ILE 179 558 558 ILE ILE A . n 
A 1 180 ARG 180 559 559 ARG ARG A . n 
A 1 181 ILE 181 560 560 ILE ILE A . n 
A 1 182 THR 182 561 561 THR THR A . n 
A 1 183 PRO 183 562 562 PRO PRO A . n 
A 1 184 ARG 184 563 563 ARG ARG A . n 
A 1 185 GLY 185 564 564 GLY GLY A . n 
A 1 186 ILE 186 565 565 ILE ILE A . n 
A 1 187 PHE 187 566 566 PHE PHE A . n 
A 1 188 ASP 188 567 567 ASP ASP A . n 
A 1 189 VAL 189 568 568 VAL VAL A . n 
A 1 190 MET 190 569 569 MET MET A . n 
A 1 191 LYS 191 570 570 LYS LYS A . n 
A 1 192 LYS 192 571 571 LYS LYS A . n 
A 1 193 THR 193 572 572 THR THR A . n 
A 1 194 VAL 194 573 573 VAL VAL A . n 
A 1 195 LEU 195 574 574 LEU LEU A . n 
A 1 196 PHE 196 575 575 PHE PHE A . n 
A 1 197 PRO 197 576 576 PRO PRO A . n 
A 1 198 SER 198 577 577 SER SER A . n 
A 1 199 ILE 199 578 578 ILE ILE A . n 
A 1 200 MET 200 579 579 MET MET A . n 
A 1 201 ARG 201 580 580 ARG ARG A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 HOH 1  601 74  HOH HOH A . 
B 2 HOH 2  602 20  HOH HOH A . 
B 2 HOH 3  603 60  HOH HOH A . 
B 2 HOH 4  604 97  HOH HOH A . 
B 2 HOH 5  605 107 HOH HOH A . 
B 2 HOH 6  606 63  HOH HOH A . 
B 2 HOH 7  607 27  HOH HOH A . 
B 2 HOH 8  608 15  HOH HOH A . 
B 2 HOH 9  609 61  HOH HOH A . 
B 2 HOH 10 610 82  HOH HOH A . 
B 2 HOH 11 611 6   HOH HOH A . 
B 2 HOH 12 612 92  HOH HOH A . 
B 2 HOH 13 613 109 HOH HOH A . 
B 2 HOH 14 614 24  HOH HOH A . 
B 2 HOH 15 615 5   HOH HOH A . 
B 2 HOH 16 616 28  HOH HOH A . 
B 2 HOH 17 617 50  HOH HOH A . 
B 2 HOH 18 618 26  HOH HOH A . 
B 2 HOH 19 619 9   HOH HOH A . 
B 2 HOH 20 620 35  HOH HOH A . 
B 2 HOH 21 621 37  HOH HOH A . 
B 2 HOH 22 622 12  HOH HOH A . 
B 2 HOH 23 623 96  HOH HOH A . 
B 2 HOH 24 624 108 HOH HOH A . 
B 2 HOH 25 625 43  HOH HOH A . 
B 2 HOH 26 626 58  HOH HOH A . 
B 2 HOH 27 627 33  HOH HOH A . 
B 2 HOH 28 628 88  HOH HOH A . 
B 2 HOH 29 629 55  HOH HOH A . 
B 2 HOH 30 630 42  HOH HOH A . 
B 2 HOH 31 631 83  HOH HOH A . 
B 2 HOH 32 632 54  HOH HOH A . 
B 2 HOH 33 633 2   HOH HOH A . 
B 2 HOH 34 634 62  HOH HOH A . 
B 2 HOH 35 635 16  HOH HOH A . 
B 2 HOH 36 636 8   HOH HOH A . 
B 2 HOH 37 637 49  HOH HOH A . 
B 2 HOH 38 638 11  HOH HOH A . 
B 2 HOH 39 639 53  HOH HOH A . 
B 2 HOH 40 640 7   HOH HOH A . 
B 2 HOH 41 641 87  HOH HOH A . 
B 2 HOH 42 642 32  HOH HOH A . 
B 2 HOH 43 643 73  HOH HOH A . 
B 2 HOH 44 644 13  HOH HOH A . 
B 2 HOH 45 645 39  HOH HOH A . 
B 2 HOH 46 646 90  HOH HOH A . 
B 2 HOH 47 647 21  HOH HOH A . 
B 2 HOH 48 648 36  HOH HOH A . 
B 2 HOH 49 649 14  HOH HOH A . 
B 2 HOH 50 650 19  HOH HOH A . 
B 2 HOH 51 651 17  HOH HOH A . 
B 2 HOH 52 652 47  HOH HOH A . 
B 2 HOH 53 653 3   HOH HOH A . 
B 2 HOH 54 654 18  HOH HOH A . 
B 2 HOH 55 655 23  HOH HOH A . 
B 2 HOH 56 656 67  HOH HOH A . 
B 2 HOH 57 657 64  HOH HOH A . 
B 2 HOH 58 658 22  HOH HOH A . 
B 2 HOH 59 659 52  HOH HOH A . 
B 2 HOH 60 660 48  HOH HOH A . 
B 2 HOH 61 661 79  HOH HOH A . 
B 2 HOH 62 662 105 HOH HOH A . 
B 2 HOH 63 663 25  HOH HOH A . 
B 2 HOH 64 664 4   HOH HOH A . 
B 2 HOH 65 665 86  HOH HOH A . 
B 2 HOH 66 666 41  HOH HOH A . 
B 2 HOH 67 667 46  HOH HOH A . 
B 2 HOH 68 668 94  HOH HOH A . 
B 2 HOH 69 669 65  HOH HOH A . 
B 2 HOH 70 670 81  HOH HOH A . 
B 2 HOH 71 671 59  HOH HOH A . 
B 2 HOH 72 672 31  HOH HOH A . 
B 2 HOH 73 673 85  HOH HOH A . 
B 2 HOH 74 674 72  HOH HOH A . 
B 2 HOH 75 675 30  HOH HOH A . 
B 2 HOH 76 676 10  HOH HOH A . 
B 2 HOH 77 677 95  HOH HOH A . 
B 2 HOH 78 678 66  HOH HOH A . 
B 2 HOH 79 679 56  HOH HOH A . 
B 2 HOH 80 680 93  HOH HOH A . 
B 2 HOH 81 681 104 HOH HOH A . 
B 2 HOH 82 682 99  HOH HOH A . 
B 2 HOH 83 683 78  HOH HOH A . 
B 2 HOH 84 684 100 HOH HOH A . 
B 2 HOH 85 685 76  HOH HOH A . 
B 2 HOH 86 686 75  HOH HOH A . 
B 2 HOH 87 687 69  HOH HOH A . 
B 2 HOH 88 688 71  HOH HOH A . 
B 2 HOH 89 689 34  HOH HOH A . 
B 2 HOH 90 690 80  HOH HOH A . 
B 2 HOH 91 691 77  HOH HOH A . 
B 2 HOH 92 692 89  HOH HOH A . 
B 2 HOH 93 693 44  HOH HOH A . 
B 2 HOH 94 694 102 HOH HOH A . 
B 2 HOH 95 695 68  HOH HOH A . 
B 2 HOH 96 696 91  HOH HOH A . 
B 2 HOH 97 697 40  HOH HOH A . 
B 2 HOH 98 699 70  HOH HOH A . 
B 2 HOH 99 700 57  HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A VAL 383 ? CG1 ? A VAL 4   CG1 
2  1 Y 1 A VAL 383 ? CG2 ? A VAL 4   CG2 
3  1 Y 1 A GLU 386 ? CG  ? A GLU 7   CG  
4  1 Y 1 A GLU 386 ? CD  ? A GLU 7   CD  
5  1 Y 1 A GLU 386 ? OE1 ? A GLU 7   OE1 
6  1 Y 1 A GLU 386 ? OE2 ? A GLU 7   OE2 
7  1 Y 1 A ARG 563 ? CG  ? A ARG 184 CG  
8  1 Y 1 A ARG 563 ? CD  ? A ARG 184 CD  
9  1 Y 1 A ARG 563 ? NE  ? A ARG 184 NE  
10 1 Y 1 A ARG 563 ? CZ  ? A ARG 184 CZ  
11 1 Y 1 A ARG 563 ? NH1 ? A ARG 184 NH1 
12 1 Y 1 A ARG 563 ? NH2 ? A ARG 184 NH2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.21.1_5286 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-3000 ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? HKL-3000 ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9JQL 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     103.169 
_cell.length_a_esd                 ? 
_cell.length_b                     103.169 
_cell.length_b_esd                 ? 
_cell.length_c                     42.629 
_cell.length_c_esd                 ? 
_cell.volume                       453736.365 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9JQL 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                96 
_symmetry.space_group_name_Hall            'P 4nw 2abw' 
_symmetry.space_group_name_H-M             'P 43 21 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9JQL 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.40 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          48.82 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '1.5 M KH2PO4 and 0.1 M HEPES (pH7.0)' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            277 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS3 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-11-11 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.54056 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL19U1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.54056 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL19U1 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          26.39 
_reflns.entry_id                                       9JQL 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.10 
_reflns.d_resolution_low                               23.76 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     13926 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.9 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                10.4 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          18.2 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.124 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.118 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.10 
_reflns_shell.d_res_low                                     2.21 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           3.9 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             13964 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               10.8 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.887 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          100 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.682 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               29.09 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9JQL 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.10 
_refine.ls_d_res_low                             23.76 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     13926 
_refine.ls_number_reflns_R_free                  668 
_refine.ls_number_reflns_R_work                  13258 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.82 
_refine.ls_percent_reflns_R_free                 4.80 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2065 
_refine.ls_R_factor_R_free                       0.2103 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2062 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 21.6437 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1836 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.10 
_refine_hist.d_res_low                        23.76 
_refine_hist.number_atoms_solvent             101 
_refine_hist.number_atoms_total               1674 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1573 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0028  ? 1603 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.6085  ? 2162 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0451  ? 244  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0046  ? 276  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 17.2650 ? 601  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.10 2.26  . . 137 2587 100.00 . . . . 0.2260 . . . . . . . . . . . 0.2706 
'X-RAY DIFFRACTION' 2.26 2.49  . . 105 2646 100.00 . . . . 0.2308 . . . . . . . . . . . 0.2795 
'X-RAY DIFFRACTION' 2.49 2.85  . . 142 2608 99.96  . . . . 0.2264 . . . . . . . . . . . 0.2414 
'X-RAY DIFFRACTION' 2.85 3.59  . . 134 2648 100.00 . . . . 0.2100 . . . . . . . . . . . 0.2108 
'X-RAY DIFFRACTION' 3.59 23.76 . . 150 2769 99.18  . . . . 0.1842 . . . . . . . . . . . 0.1742 
# 
_struct.entry_id                     9JQL 
_struct.title                        'The C-terminal structure of N6-methyladenosine deaminase' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9JQL 
_struct_keywords.text            'Epigenetic nucleoside deaminase, Metal-dependent hydrolases, YerA, METAL BINDING PROTEIN' 
_struct_keywords.pdbx_keywords   'METAL BINDING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    YERA_BACSU 
_struct_ref.pdbx_db_accession          O34909 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;GGLVPLELSYDMTMDDLQFSMPMGVKMRNAVIMEPYMIEIDNSMEQLSFDHDESYLTMLDRHGKWRVNTMIKGFASSVQG
FVSSFTTTGDIVAIGKNKADMLLAFARMKEIGGGIVLAENGNILHEIPLALCGCASSEAYEDVLEKEQKLRDLLTERGYE
FCDPIYTLLFLQSTHLPYIRITPRGIFDVMKKTVLFPSIMR
;
_struct_ref.pdbx_align_begin           380 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9JQL 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 201 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             O34909 
_struct_ref_seq.db_align_beg                  380 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  580 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       380 
_struct_ref_seq.pdbx_auth_seq_align_end       580 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   homology 
_pdbx_struct_assembly_auth_evidence.details                PDBePISA 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 THR A 13  ? GLN A 18  ? THR A 392 GLN A 397 5 ? 6  
HELX_P HELX_P2 AA2 ASN A 97  ? ILE A 111 ? ASN A 476 ILE A 490 1 ? 15 
HELX_P HELX_P3 AA3 LEU A 129 ? GLY A 133 ? LEU A 508 GLY A 512 1 ? 5  
HELX_P HELX_P4 AA4 SER A 136 ? GLU A 138 ? SER A 515 GLU A 517 5 ? 3  
HELX_P HELX_P5 AA5 ALA A 139 ? ARG A 157 ? ALA A 518 ARG A 536 1 ? 19 
HELX_P HELX_P6 AA6 ASP A 163 ? PHE A 170 ? ASP A 542 PHE A 549 1 ? 8  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            disulf1 
_struct_conn.conn_type_id                  disulf 
_struct_conn.pdbx_leaving_atom_flag        ? 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           A 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            134 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           A 
_struct_conn.ptnr2_label_comp_id           CYS 
_struct_conn.ptnr2_label_seq_id            162 
_struct_conn.ptnr2_label_atom_id           SG 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            A 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             513 
_struct_conn.ptnr2_auth_asym_id            A 
_struct_conn.ptnr2_auth_comp_id            CYS 
_struct_conn.ptnr2_auth_seq_id             541 
_struct_conn.ptnr2_symmetry                8_554 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               2.025 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      CYS 
_pdbx_modification_feature.label_asym_id                      A 
_pdbx_modification_feature.label_seq_id                       134 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      162 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       CYS 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        513 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       541 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          8_554 
_pdbx_modification_feature.comp_id_linking_atom               SG 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                . 
_pdbx_modification_feature.ref_pcm_id                         . 
_pdbx_modification_feature.ref_comp_id                        . 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Disulfide bridge' 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          PRO 
_struct_mon_prot_cis.label_seq_id           177 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           PRO 
_struct_mon_prot_cis.auth_seq_id            556 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   TYR 
_struct_mon_prot_cis.pdbx_label_seq_id_2    178 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    TYR 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     557 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       4.18 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 8 ? 
AA2 ? 4 ? 
AA3 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? parallel      
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA1 7 8 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? parallel      
AA2 3 4 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 MET A 33  ? MET A 37  ? MET A 412 MET A 416 
AA1 2 MET A 23  ? MET A 27  ? MET A 402 MET A 406 
AA1 3 TRP A 65  ? LYS A 72  ? TRP A 444 LYS A 451 
AA1 4 GLU A 53  ? LEU A 59  ? GLU A 432 LEU A 438 
AA1 5 ILE A 91  ? GLY A 95  ? ILE A 470 GLY A 474 
AA1 6 GLY A 80  ? SER A 83  ? GLY A 459 SER A 462 
AA1 7 GLY A 114 ? GLU A 119 ? GLY A 493 GLU A 498 
AA1 8 ASN A 122 ? PRO A 128 ? ASN A 501 PRO A 507 
AA2 1 MET A 33  ? MET A 37  ? MET A 412 MET A 416 
AA2 2 MET A 23  ? MET A 27  ? MET A 402 MET A 406 
AA2 3 TRP A 65  ? LYS A 72  ? TRP A 444 LYS A 451 
AA2 4 ILE A 199 ? MET A 200 ? ILE A 578 MET A 579 
AA3 1 ILE A 179 ? THR A 182 ? ILE A 558 THR A 561 
AA3 2 GLY A 185 ? ASP A 188 ? GLY A 564 ASP A 567 
AA3 3 THR A 193 ? PRO A 197 ? THR A 572 PRO A 576 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O TYR A 36  ? O TYR A 415 N GLY A 24  ? N GLY A 403 
AA1 2 3 N VAL A 25  ? N VAL A 404 O MET A 70  ? O MET A 449 
AA1 3 4 O THR A 69  ? O THR A 448 N LEU A 56  ? N LEU A 435 
AA1 4 5 N THR A 57  ? N THR A 436 O ALA A 93  ? O ALA A 472 
AA1 5 6 O ILE A 94  ? O ILE A 473 N PHE A 81  ? N PHE A 460 
AA1 6 7 N VAL A 82  ? N VAL A 461 O VAL A 116 ? O VAL A 495 
AA1 7 8 N GLU A 119 ? N GLU A 498 O ASN A 122 ? O ASN A 501 
AA2 1 2 O TYR A 36  ? O TYR A 415 N GLY A 24  ? N GLY A 403 
AA2 2 3 N VAL A 25  ? N VAL A 404 O MET A 70  ? O MET A 449 
AA2 3 4 N ARG A 66  ? N ARG A 445 O ILE A 199 ? O ILE A 578 
AA3 1 2 N THR A 182 ? N THR A 561 O GLY A 185 ? O GLY A 564 
AA3 2 3 N ILE A 186 ? N ILE A 565 O LEU A 195 ? O LEU A 574 
# 
_pdbx_entry_details.entry_id                   9JQL 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASN A 408 ? ? -137.26 -152.49 
2 1 ASN A 421 ? ? -93.21  30.49   
3 1 LEU A 574 ? ? -88.87  -99.05  
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z               
2 -y+1/2,x+1/2,z+3/4  
3 y+1/2,-x+1/2,z+1/4  
4 x+1/2,-y+1/2,-z+1/4 
5 -x+1/2,y+1/2,-z+3/4 
6 -x,-y,z+1/2         
7 y,x,-z              
8 -y,-x,-z+1/2        
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           2022A1515011768 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'in silico model' 
_pdbx_initial_refinement_model.source_name      AlphaFold 
_pdbx_initial_refinement_model.accession_code   AF-O34909-F1 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 43 21 2' 
_space_group.name_Hall        'P 4nw 2abw' 
_space_group.IT_number        96 
_space_group.crystal_system   tetragonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    9JQL 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.009693 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.009693 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.023458 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . GLY A 1 1   ? 21.48433 -5.76785  15.49478  1.000 51.31204 ? 380 GLY A N   1 
ATOM   2    C CA  . GLY A 1 1   ? 22.10013 -7.06250  15.24241  1.000 51.75417 ? 380 GLY A CA  1 
ATOM   3    C C   . GLY A 1 1   ? 21.10717 -8.15552  14.87693  1.000 62.40680 ? 380 GLY A C   1 
ATOM   4    O O   . GLY A 1 1   ? 19.94044 -7.86471  14.58024  1.000 68.64543 ? 380 GLY A O   1 
ATOM   5    N N   . GLY A 1 2   ? 21.56734 -9.40860  14.89671  1.000 56.92052 ? 381 GLY A N   1 
ATOM   6    C CA  . GLY A 1 2   ? 20.71853 -10.52518 14.53374  1.000 59.71287 ? 381 GLY A CA  1 
ATOM   7    C C   . GLY A 1 2   ? 20.73058 -11.65749 15.53228  1.000 61.74036 ? 381 GLY A C   1 
ATOM   8    O O   . GLY A 1 2   ? 21.80373 -12.14576 15.89096  1.000 57.49141 ? 381 GLY A O   1 
ATOM   9    N N   . LEU A 1 3   ? 19.54789 -12.07570 15.99205  1.000 63.62992 ? 382 LEU A N   1 
ATOM   10   C CA  . LEU A 1 3   ? 19.45801 -13.22899 16.87605  1.000 65.43855 ? 382 LEU A CA  1 
ATOM   11   C C   . LEU A 1 3   ? 19.66041 -14.52371 16.10296  1.000 68.34970 ? 382 LEU A C   1 
ATOM   12   O O   . LEU A 1 3   ? 20.29886 -15.45942 16.59548  1.000 73.31970 ? 382 LEU A O   1 
ATOM   13   C CB  . LEU A 1 3   ? 18.10754 -13.24059 17.59523  1.000 59.58500 ? 382 LEU A CB  1 
ATOM   14   C CG  . LEU A 1 3   ? 17.99984 -12.47755 18.91644  1.000 53.41628 ? 382 LEU A CG  1 
ATOM   15   C CD1 . LEU A 1 3   ? 18.03054 -10.97568 18.69265  1.000 50.31703 ? 382 LEU A CD1 1 
ATOM   16   C CD2 . LEU A 1 3   ? 16.73569 -12.88209 19.65139  1.000 50.59970 ? 382 LEU A CD2 1 
ATOM   17   N N   . VAL A 1 4   ? 19.11944 -14.59948 14.88487  1.000 70.58394 ? 383 VAL A N   1 
ATOM   18   C CA  . VAL A 1 4   ? 19.31258 -15.77447 14.04082  1.000 71.05185 ? 383 VAL A CA  1 
ATOM   19   C C   . VAL A 1 4   ? 19.97452 -15.33364 12.73552  1.000 67.44577 ? 383 VAL A C   1 
ATOM   20   O O   . VAL A 1 4   ? 19.30366 -15.25902 11.69972  1.000 67.89597 ? 383 VAL A O   1 
ATOM   21   C CB  . VAL A 1 4   ? 17.98943 -16.51359 13.78216  1.000 73.00329 ? 383 VAL A CB  1 
ATOM   22   N N   . PRO A 1 5   ? 21.26411 -15.03305 12.73779  1.000 63.84038 ? 384 PRO A N   1 
ATOM   23   C CA  . PRO A 1 5   ? 21.90425 -14.55144 11.51224  1.000 53.49911 ? 384 PRO A CA  1 
ATOM   24   C C   . PRO A 1 5   ? 22.23051 -15.69298 10.56073  1.000 57.40106 ? 384 PRO A C   1 
ATOM   25   O O   . PRO A 1 5   ? 22.27659 -16.86861 10.93238  1.000 60.06209 ? 384 PRO A O   1 
ATOM   26   C CB  . PRO A 1 5   ? 23.17759 -13.87784 12.03325  1.000 56.16952 ? 384 PRO A CB  1 
ATOM   27   C CG  . PRO A 1 5   ? 23.53490 -14.68842 13.23850  1.000 59.14742 ? 384 PRO A CG  1 
ATOM   28   C CD  . PRO A 1 5   ? 22.22438 -15.12864 13.85498  1.000 63.85703 ? 384 PRO A CD  1 
ATOM   29   N N   . LEU A 1 6   ? 22.45002 -15.31957 9.30426   1.000 50.82556 ? 385 LEU A N   1 
ATOM   30   C CA  . LEU A 1 6   ? 22.93982 -16.26945 8.31605   1.000 48.23200 ? 385 LEU A CA  1 
ATOM   31   C C   . LEU A 1 6   ? 24.27646 -16.84305 8.77614   1.000 54.54626 ? 385 LEU A C   1 
ATOM   32   O O   . LEU A 1 6   ? 25.26423 -16.11228 8.91503   1.000 65.83970 ? 385 LEU A O   1 
ATOM   33   C CB  . LEU A 1 6   ? 23.08489 -15.58685 6.95909   1.000 47.28180 ? 385 LEU A CB  1 
ATOM   34   C CG  . LEU A 1 6   ? 22.93514 -16.46822 5.72537   1.000 45.50661 ? 385 LEU A CG  1 
ATOM   35   C CD1 . LEU A 1 6   ? 21.46975 -16.82693 5.49775   1.000 45.89502 ? 385 LEU A CD1 1 
ATOM   36   C CD2 . LEU A 1 6   ? 23.51812 -15.77673 4.49893   1.000 43.65970 ? 385 LEU A CD2 1 
ATOM   37   N N   . GLU A 1 7   ? 24.29478 -18.15046 9.04535   1.000 57.27905 ? 386 GLU A N   1 
ATOM   38   C CA  . GLU A 1 7   ? 25.47081 -18.81623 9.60689   1.000 61.77953 ? 386 GLU A CA  1 
ATOM   39   C C   . GLU A 1 7   ? 26.35137 -19.29590 8.45811   1.000 60.00325 ? 386 GLU A C   1 
ATOM   40   O O   . GLU A 1 7   ? 26.46016 -20.48916 8.16080   1.000 56.80590 ? 386 GLU A O   1 
ATOM   41   C CB  . GLU A 1 7   ? 25.05917 -19.95782 10.53142  1.000 60.74956 ? 386 GLU A CB  1 
ATOM   42   N N   . LEU A 1 8   ? 27.00788 -18.33356 7.81696   1.000 46.46210 ? 387 LEU A N   1 
ATOM   43   C CA  . LEU A 1 8   ? 28.01274 -18.65328 6.82101   1.000 49.48396 ? 387 LEU A CA  1 
ATOM   44   C C   . LEU A 1 8   ? 29.31497 -19.02801 7.51364   1.000 51.19384 ? 387 LEU A C   1 
ATOM   45   O O   . LEU A 1 8   ? 29.66670 -18.48283 8.56265   1.000 53.65520 ? 387 LEU A O   1 
ATOM   46   C CB  . LEU A 1 8   ? 28.24184 -17.47743 5.87305   1.000 48.15249 ? 387 LEU A CB  1 
ATOM   47   C CG  . LEU A 1 8   ? 27.07066 -17.08242 4.96560   1.000 39.64591 ? 387 LEU A CG  1 
ATOM   48   C CD1 . LEU A 1 8   ? 27.44687 -15.87602 4.11980   1.000 40.51764 ? 387 LEU A CD1 1 
ATOM   49   C CD2 . LEU A 1 8   ? 26.67162 -18.25088 4.09231   1.000 39.21819 ? 387 LEU A CD2 1 
ATOM   50   N N   . SER A 1 9   ? 30.03642 -19.96320 6.91511   1.000 49.38810 ? 388 SER A N   1 
ATOM   51   C CA  . SER A 1 9   ? 31.28422 -20.43168 7.52118   1.000 49.33540 ? 388 SER A CA  1 
ATOM   52   C C   . SER A 1 9   ? 32.38940 -19.39092 7.45862   1.000 49.97211 ? 388 SER A C   1 
ATOM   53   O O   . SER A 1 9   ? 33.53848 -19.72738 7.81066   1.000 51.64431 ? 388 SER A O   1 
ATOM   54   C CB  . SER A 1 9   ? 31.76276 -21.71534 6.83819   1.000 53.37711 ? 388 SER A CB  1 
ATOM   55   O OG  . SER A 1 9   ? 32.57125 -21.41051 5.72017   1.000 54.99481 ? 388 SER A OG  1 
ATOM   56   N N   . TYR A 1 10  ? 32.10750 -18.15548 7.04412   1.000 50.20048 ? 389 TYR A N   1 
ATOM   57   C CA  . TYR A 1 10  ? 33.16833 -17.18001 6.83293   1.000 41.06869 ? 389 TYR A CA  1 
ATOM   58   C C   . TYR A 1 10  ? 32.61105 -15.77063 6.94850   1.000 39.48680 ? 389 TYR A C   1 
ATOM   59   O O   . TYR A 1 10  ? 31.42915 -15.51803 6.68591   1.000 39.30542 ? 389 TYR A O   1 
ATOM   60   C CB  . TYR A 1 10  ? 33.83686 -17.37083 5.46820   1.000 40.79607 ? 389 TYR A CB  1 
ATOM   61   C CG  . TYR A 1 10  ? 32.92296 -17.03392 4.30922   1.000 35.78266 ? 389 TYR A CG  1 
ATOM   62   C CD1 . TYR A 1 10  ? 31.90265 -17.90047 3.92104   1.000 32.67984 ? 389 TYR A CD1 1 
ATOM   63   C CD2 . TYR A 1 10  ? 33.09001 -15.85724 3.59051   1.000 37.24716 ? 389 TYR A CD2 1 
ATOM   64   C CE1 . TYR A 1 10  ? 31.07482 -17.59377 2.85619   1.000 32.69750 ? 389 TYR A CE1 1 
ATOM   65   C CE2 . TYR A 1 10  ? 32.26946 -15.54863 2.52633   1.000 31.32145 ? 389 TYR A CE2 1 
ATOM   66   C CZ  . TYR A 1 10  ? 31.26326 -16.41705 2.16020   1.000 28.42204 ? 389 TYR A CZ  1 
ATOM   67   O OH  . TYR A 1 10  ? 30.43926 -16.11396 1.09663   1.000 30.03187 ? 389 TYR A OH  1 
ATOM   68   N N   . ASP A 1 11  ? 33.48543 -14.85052 7.34766   1.000 36.62767 ? 390 ASP A N   1 
ATOM   69   C CA  . ASP A 1 11  ? 33.22639 -13.42716 7.24005   1.000 36.83069 ? 390 ASP A CA  1 
ATOM   70   C C   . ASP A 1 11  ? 33.94812 -12.89443 6.01199   1.000 32.61492 ? 390 ASP A C   1 
ATOM   71   O O   . ASP A 1 11  ? 35.00810 -13.39976 5.63088   1.000 33.62397 ? 390 ASP A O   1 
ATOM   72   C CB  . ASP A 1 11  ? 33.70534 -12.67975 8.48321   1.000 36.69933 ? 390 ASP A CB  1 
ATOM   73   C CG  . ASP A 1 11  ? 33.14860 -13.25677 9.76420   1.000 44.01465 ? 390 ASP A CG  1 
ATOM   74   O OD1 . ASP A 1 11  ? 31.91204 -13.36248 9.88346   1.000 43.22957 ? 390 ASP A OD1 1 
ATOM   75   O OD2 . ASP A 1 11  ? 33.95758 -13.60393 10.65047  1.000 43.18420 ? 390 ASP A OD2 1 
ATOM   76   N N   . MET A 1 12  ? 33.36976 -11.87342 5.38916   1.000 32.71063 ? 391 MET A N   1 
ATOM   77   C CA  . MET A 1 12  ? 34.01857 -11.23506 4.25380   1.000 30.44168 ? 391 MET A CA  1 
ATOM   78   C C   . MET A 1 12  ? 34.97732 -10.16420 4.75054   1.000 29.22528 ? 391 MET A C   1 
ATOM   79   O O   . MET A 1 12  ? 34.57927 -9.25051  5.48063   1.000 27.91118 ? 391 MET A O   1 
ATOM   80   C CB  . MET A 1 12  ? 32.98931 -10.61700 3.31379   1.000 27.20163 ? 391 MET A CB  1 
ATOM   81   C CG  . MET A 1 12  ? 33.58483 -9.97767  2.07226   1.000 28.40897 ? 391 MET A CG  1 
ATOM   82   S SD  . MET A 1 12  ? 32.34757 -9.25095  0.98657   1.000 26.03990 ? 391 MET A SD  1 
ATOM   83   C CE  . MET A 1 12  ? 33.36449 -8.77850  -0.40399  1.000 24.13354 ? 391 MET A CE  1 
ATOM   84   N N   . THR A 1 13  ? 36.23593 -10.27259 4.34807   1.000 30.04641 ? 392 THR A N   1 
ATOM   85   C CA  . THR A 1 13  ? 37.28075 -9.37597  4.80764   1.000 27.84934 ? 392 THR A CA  1 
ATOM   86   C C   . THR A 1 13  ? 37.87777 -8.62143  3.62772   1.000 33.05551 ? 392 THR A C   1 
ATOM   87   O O   . THR A 1 13  ? 37.52934 -8.84649  2.46661   1.000 30.03212 ? 392 THR A O   1 
ATOM   88   C CB  . THR A 1 13  ? 38.37984 -10.14821 5.54623   1.000 30.13276 ? 392 THR A CB  1 
ATOM   89   O OG1 . THR A 1 13  ? 39.20927 -10.82506 4.59348   1.000 33.23906 ? 392 THR A OG1 1 
ATOM   90   C CG2 . THR A 1 13  ? 37.77164 -11.17078 6.49640   1.000 32.37117 ? 392 THR A CG2 1 
ATOM   91   N N   . MET A 1 14  ? 38.79604 -7.71147  3.94761   1.000 27.49940 ? 393 MET A N   1 
ATOM   92   C CA  . MET A 1 14  ? 39.48447 -6.94441  2.91900   1.000 30.19237 ? 393 MET A CA  1 
ATOM   93   C C   . MET A 1 14  ? 40.26362 -7.82876  1.95465   1.000 30.63221 ? 393 MET A C   1 
ATOM   94   O O   . MET A 1 14  ? 40.46476 -7.43550  0.79894   1.000 31.99603 ? 393 MET A O   1 
ATOM   95   C CB  . MET A 1 14  ? 40.41889 -5.94016  3.58017   1.000 31.99789 ? 393 MET A CB  1 
ATOM   96   C CG  . MET A 1 14  ? 40.65161 -4.68324  2.76381   1.000 35.76081 ? 393 MET A CG  1 
ATOM   97   S SD  . MET A 1 14  ? 39.14542 -3.76891  2.36822   1.000 34.40599 ? 393 MET A SD  1 
ATOM   98   C CE  . MET A 1 14  ? 38.88078 -2.82868  3.86527   1.000 43.64571 ? 393 MET A CE  1 
ATOM   99   N N   . ASP A 1 15  ? 40.68928 -9.01620  2.39846   1.000 31.18611 ? 394 ASP A N   1 
ATOM   100  C CA  . ASP A 1 15  ? 41.36279 -9.96108  1.51654   1.000 31.28809 ? 394 ASP A CA  1 
ATOM   101  C C   . ASP A 1 15  ? 40.44852 -10.47941 0.41383   1.000 31.64230 ? 394 ASP A C   1 
ATOM   102  O O   . ASP A 1 15  ? 40.94304 -10.90361 -0.63605  1.000 28.19703 ? 394 ASP A O   1 
ATOM   103  C CB  . ASP A 1 15  ? 41.90497 -11.13831 2.32677   1.000 35.66666 ? 394 ASP A CB  1 
ATOM   104  C CG  . ASP A 1 15  ? 43.02707 -10.73493 3.26120   1.000 37.99998 ? 394 ASP A CG  1 
ATOM   105  O OD1 . ASP A 1 15  ? 43.51621 -9.59431  3.13819   1.000 35.22278 ? 394 ASP A OD1 1 
ATOM   106  O OD2 . ASP A 1 15  ? 43.42059 -11.55349 4.11503   1.000 42.37826 ? 394 ASP A OD2 1 
ATOM   107  N N   . ASP A 1 16  ? 39.13480 -10.48662 0.63634   1.000 26.17485 ? 395 ASP A N   1 
ATOM   108  C CA  . ASP A 1 16  ? 38.18365 -10.83630 -0.40976  1.000 28.98389 ? 395 ASP A CA  1 
ATOM   109  C C   . ASP A 1 16  ? 37.94101 -9.67577  -1.36576  1.000 29.66433 ? 395 ASP A C   1 
ATOM   110  O O   . ASP A 1 16  ? 37.19707 -9.82665  -2.33904  1.000 25.19818 ? 395 ASP A O   1 
ATOM   111  C CB  . ASP A 1 16  ? 36.85870 -11.28380 0.21080   1.000 26.49903 ? 395 ASP A CB  1 
ATOM   112  C CG  . ASP A 1 16  ? 37.00978 -12.50573 1.09707   1.000 33.11691 ? 395 ASP A CG  1 
ATOM   113  O OD1 . ASP A 1 16  ? 37.48765 -13.55401 0.61713   1.000 29.91296 ? 395 ASP A OD1 1 
ATOM   114  O OD2 . ASP A 1 16  ? 36.64688 -12.41706 2.28234   1.000 30.45873 ? 395 ASP A OD2 1 
ATOM   115  N N   . LEU A 1 17  ? 38.54440 -8.51750  -1.10910  1.000 26.60058 ? 396 LEU A N   1 
ATOM   116  C CA  . LEU A 1 17  ? 38.40496 -7.33907  -1.95813  1.000 29.58463 ? 396 LEU A CA  1 
ATOM   117  C C   . LEU A 1 17  ? 39.73287 -6.97674  -2.62204  1.000 26.89818 ? 396 LEU A C   1 
ATOM   118  O O   . LEU A 1 17  ? 40.09575 -5.80742  -2.72943  1.000 24.84221 ? 396 LEU A O   1 
ATOM   119  C CB  . LEU A 1 17  ? 37.83258 -6.16786  -1.15930  1.000 24.32560 ? 396 LEU A CB  1 
ATOM   120  C CG  . LEU A 1 17  ? 36.36613 -6.39272  -0.79456  1.000 25.12560 ? 396 LEU A CG  1 
ATOM   121  C CD1 . LEU A 1 17  ? 35.86102 -5.32277  0.15317   1.000 26.08429 ? 396 LEU A CD1 1 
ATOM   122  C CD2 . LEU A 1 17  ? 35.52055 -6.43009  -2.05569  1.000 27.81789 ? 396 LEU A CD2 1 
ATOM   123  N N   . GLN A 1 18  ? 40.47120 -7.98992  -3.07009  1.000 24.64952 ? 397 GLN A N   1 
ATOM   124  C CA  . GLN A 1 18  ? 41.67762 -7.81119  -3.87036  1.000 27.51271 ? 397 GLN A CA  1 
ATOM   125  C C   . GLN A 1 18  ? 41.33435 -8.06478  -5.33132  1.000 27.97739 ? 397 GLN A C   1 
ATOM   126  O O   . GLN A 1 18  ? 40.91992 -9.17412  -5.69208  1.000 25.10078 ? 397 GLN A O   1 
ATOM   127  C CB  . GLN A 1 18  ? 42.78814 -8.75837  -3.41170  1.000 29.90972 ? 397 GLN A CB  1 
ATOM   128  C CG  . GLN A 1 18  ? 43.50326 -8.35972  -2.13420  1.000 39.57364 ? 397 GLN A CG  1 
ATOM   129  C CD  . GLN A 1 18  ? 44.62862 -9.31238  -1.77936  1.000 48.80773 ? 397 GLN A CD  1 
ATOM   130  O OE1 . GLN A 1 18  ? 44.38842 -10.43622 -1.34124  1.000 46.71650 ? 397 GLN A OE1 1 
ATOM   131  N NE2 . GLN A 1 18  ? 45.86668 -8.87827  -2.00179  1.000 50.49780 ? 397 GLN A NE2 1 
ATOM   132  N N   . PHE A 1 19  ? 41.50603 -7.04766  -6.17138  1.000 21.81118 ? 398 PHE A N   1 
ATOM   133  C CA  . PHE A 1 19  ? 41.12137 -7.10165  -7.57302  1.000 24.73418 ? 398 PHE A CA  1 
ATOM   134  C C   . PHE A 1 19  ? 42.36093 -6.96493  -8.44484  1.000 31.15484 ? 398 PHE A C   1 
ATOM   135  O O   . PHE A 1 19  ? 43.15105 -6.03101  -8.26419  1.000 32.27025 ? 398 PHE A O   1 
ATOM   136  C CB  . PHE A 1 19  ? 40.11766 -5.99458  -7.89856  1.000 21.92051 ? 398 PHE A CB  1 
ATOM   137  C CG  . PHE A 1 19  ? 38.82515 -6.10398  -7.13725  1.000 22.05004 ? 398 PHE A CG  1 
ATOM   138  C CD1 . PHE A 1 19  ? 38.71493 -5.59492  -5.85397  1.000 23.48297 ? 398 PHE A CD1 1 
ATOM   139  C CD2 . PHE A 1 19  ? 37.72793 -6.73499  -7.70120  1.000 20.15756 ? 398 PHE A CD2 1 
ATOM   140  C CE1 . PHE A 1 19  ? 37.53366 -5.70414  -5.14742  1.000 22.53392 ? 398 PHE A CE1 1 
ATOM   141  C CE2 . PHE A 1 19  ? 36.54354 -6.85004  -7.00202  1.000 20.22435 ? 398 PHE A CE2 1 
ATOM   142  C CZ  . PHE A 1 19  ? 36.44454 -6.33278  -5.72307  1.000 24.34380 ? 398 PHE A CZ  1 
ATOM   143  N N   . SER A 1 20  ? 42.53127 -7.89022  -9.38687  1.000 24.87932 ? 399 SER A N   1 
ATOM   144  C CA  . SER A 1 20  ? 43.76044 -7.91751  -10.16847 1.000 30.15899 ? 399 SER A CA  1 
ATOM   145  C C   . SER A 1 20  ? 43.52692 -8.19806  -11.65001 1.000 28.74994 ? 399 SER A C   1 
ATOM   146  O O   . SER A 1 20  ? 44.31223 -7.75046  -12.49103 1.000 29.71820 ? 399 SER A O   1 
ATOM   147  C CB  . SER A 1 20  ? 44.72235 -8.95415  -9.58657  1.000 27.43766 ? 399 SER A CB  1 
ATOM   148  O OG  . SER A 1 20  ? 44.18668 -10.25811 -9.69529  1.000 32.99881 ? 399 SER A OG  1 
ATOM   149  N N   . MET A 1 21  ? 42.47304 -8.93634  -11.99033 1.000 22.06484 ? 400 MET A N   1 
ATOM   150  C CA  . MET A 1 21  ? 42.25714 -9.29393  -13.38306 1.000 24.90899 ? 400 MET A CA  1 
ATOM   151  C C   . MET A 1 21  ? 41.95879 -8.04394  -14.22278 1.000 24.37929 ? 400 MET A C   1 
ATOM   152  O O   . MET A 1 21  ? 41.25244 -7.13998  -13.74165 1.000 25.94641 ? 400 MET A O   1 
ATOM   153  C CB  . MET A 1 21  ? 41.12839 -10.32112 -13.52372 1.000 23.72737 ? 400 MET A CB  1 
ATOM   154  C CG  . MET A 1 21  ? 39.73703 -9.83405  -13.15175 1.000 27.75957 ? 400 MET A CG  1 
ATOM   155  S SD  . MET A 1 21  ? 38.45362 -10.98047 -13.70955 1.000 22.16922 ? 400 MET A SD  1 
ATOM   156  C CE  . MET A 1 21  ? 38.76584 -12.39643 -12.65731 1.000 28.17970 ? 400 MET A CE  1 
ATOM   157  N N   . PRO A 1 22  ? 42.47215 -7.95196  -15.42817 1.000 24.11094 ? 401 PRO A N   1 
ATOM   158  C CA  . PRO A 1 22  ? 42.32597 -6.73039  -16.23413 1.000 25.25366 ? 401 PRO A CA  1 
ATOM   159  C C   . PRO A 1 22  ? 41.00938 -6.63465  -16.98551 1.000 24.31412 ? 401 PRO A C   1 
ATOM   160  O O   . PRO A 1 22  ? 40.77621 -5.62619  -17.66234 1.000 21.89607 ? 401 PRO A O   1 
ATOM   161  C CB  . PRO A 1 22  ? 43.50015 -6.82822  -17.21129 1.000 25.67561 ? 401 PRO A CB  1 
ATOM   162  C CG  . PRO A 1 22  ? 43.60843 -8.29890  -17.46860 1.000 28.50070 ? 401 PRO A CG  1 
ATOM   163  C CD  . PRO A 1 22  ? 43.26089 -8.97554  -16.15449 1.000 26.30028 ? 401 PRO A CD  1 
ATOM   164  N N   . MET A 1 23  ? 40.15121 -7.64368  -16.88656 1.000 20.25029 ? 402 MET A N   1 
ATOM   165  C CA  . MET A 1 23  ? 38.92252 -7.72190  -17.65983 1.000 22.07051 ? 402 MET A CA  1 
ATOM   166  C C   . MET A 1 23  ? 37.72204 -7.76907  -16.72591 1.000 22.04813 ? 402 MET A C   1 
ATOM   167  O O   . MET A 1 23  ? 37.76076 -8.42161  -15.67720 1.000 19.69016 ? 402 MET A O   1 
ATOM   168  C CB  . MET A 1 23  ? 38.93648 -8.95695  -18.57056 1.000 25.00052 ? 402 MET A CB  1 
ATOM   169  C CG  . MET A 1 23  ? 37.59232 -9.31838  -19.17531 1.000 25.12672 ? 402 MET A CG  1 
ATOM   170  S SD  . MET A 1 23  ? 37.65036 -10.82789 -20.15833 1.000 30.59085 ? 402 MET A SD  1 
ATOM   171  C CE  . MET A 1 23  ? 38.76871 -10.33187 -21.46741 1.000 27.29219 ? 402 MET A CE  1 
ATOM   172  N N   . GLY A 1 24  ? 36.66106 -7.06711  -17.11115 1.000 16.49401 ? 403 GLY A N   1 
ATOM   173  C CA  . GLY A 1 24  ? 35.41339 -7.10926  -16.38047 1.000 19.83080 ? 403 GLY A CA  1 
ATOM   174  C C   . GLY A 1 24  ? 34.22454 -7.34113  -17.28655 1.000 22.25111 ? 403 GLY A C   1 
ATOM   175  O O   . GLY A 1 24  ? 34.38133 -7.55192  -18.49522 1.000 19.86282 ? 403 GLY A O   1 
ATOM   176  N N   . VAL A 1 25  ? 33.02655 -7.28769  -16.71561 1.000 16.92100 ? 404 VAL A N   1 
ATOM   177  C CA  . VAL A 1 25  ? 31.79155 -7.49807  -17.45626 1.000 20.22446 ? 404 VAL A CA  1 
ATOM   178  C C   . VAL A 1 25  ? 31.07945 -6.16020  -17.59672 1.000 21.64249 ? 404 VAL A C   1 
ATOM   179  O O   . VAL A 1 25  ? 31.02953 -5.36311  -16.65204 1.000 19.76020 ? 404 VAL A O   1 
ATOM   180  C CB  . VAL A 1 25  ? 30.89883 -8.55362  -16.77278 1.000 19.17590 ? 404 VAL A CB  1 
ATOM   181  C CG1 . VAL A 1 25  ? 31.68338 -9.84963  -16.57890 1.000 16.19219 ? 404 VAL A CG1 1 
ATOM   182  C CG2 . VAL A 1 25  ? 30.38770 -8.04926  -15.42649 1.000 20.81995 ? 404 VAL A CG2 1 
ATOM   183  N N   . LYS A 1 26  ? 30.55400 -5.90387  -18.78964 1.000 18.66161 ? 405 LYS A N   1 
ATOM   184  C CA  . LYS A 1 26  ? 29.88604 -4.65214  -19.11332 1.000 21.74708 ? 405 LYS A CA  1 
ATOM   185  C C   . LYS A 1 26  ? 28.44935 -4.95017  -19.51633 1.000 19.14650 ? 405 LYS A C   1 
ATOM   186  O O   . LYS A 1 26  ? 28.20545 -5.83653  -20.33887 1.000 21.79568 ? 405 LYS A O   1 
ATOM   187  C CB  . LYS A 1 26  ? 30.62375 -3.91479  -20.23840 1.000 22.45142 ? 405 LYS A CB  1 
ATOM   188  C CG  . LYS A 1 26  ? 29.85868 -2.74178  -20.82533 1.000 19.10075 ? 405 LYS A CG  1 
ATOM   189  C CD  . LYS A 1 26  ? 30.66796 -2.07835  -21.93154 1.000 28.37465 ? 405 LYS A CD  1 
ATOM   190  C CE  . LYS A 1 26  ? 29.95247 -0.84514  -22.47405 1.000 27.31591 ? 405 LYS A CE  1 
ATOM   191  N NZ  . LYS A 1 26  ? 30.80049 -0.10903  -23.45186 1.000 34.19198 ? 405 LYS A NZ  1 
ATOM   192  N N   . MET A 1 27  ? 27.50525 -4.21302  -18.94018 1.000 19.92539 ? 406 MET A N   1 
ATOM   193  C CA  . MET A 1 27  ? 26.08577 -4.43733  -19.18368 1.000 20.27258 ? 406 MET A CA  1 
ATOM   194  C C   . MET A 1 27  ? 25.66582 -3.79996  -20.50607 1.000 22.20798 ? 406 MET A C   1 
ATOM   195  O O   . MET A 1 27  ? 25.84143 -2.59184  -20.69953 1.000 21.58026 ? 406 MET A O   1 
ATOM   196  C CB  . MET A 1 27  ? 25.27295 -3.86595  -18.02232 1.000 21.60136 ? 406 MET A CB  1 
ATOM   197  C CG  . MET A 1 27  ? 25.72141 -4.33482  -16.64063 1.000 21.95589 ? 406 MET A CG  1 
ATOM   198  S SD  . MET A 1 27  ? 24.66306 -3.71408  -15.32330 1.000 27.05670 ? 406 MET A SD  1 
ATOM   199  C CE  . MET A 1 27  ? 23.08049 -4.38697  -15.82207 1.000 22.72398 ? 406 MET A CE  1 
ATOM   200  N N   . ARG A 1 28  ? 25.13808 -4.61837  -21.42328 1.000 19.77456 ? 407 ARG A N   1 
ATOM   201  C CA  . ARG A 1 28  ? 24.44998 -4.11989  -22.61024 1.000 25.72491 ? 407 ARG A CA  1 
ATOM   202  C C   . ARG A 1 28  ? 23.01130 -3.75035  -22.29791 1.000 27.75715 ? 407 ARG A C   1 
ATOM   203  O O   . ARG A 1 28  ? 22.50774 -2.71059  -22.72100 1.000 28.73874 ? 407 ARG A O   1 
ATOM   204  C CB  . ARG A 1 28  ? 24.46115 -5.16110  -23.73799 1.000 26.12213 ? 407 ARG A CB  1 
ATOM   205  C CG  . ARG A 1 28  ? 25.83523 -5.67125  -24.18927 1.000 34.85909 ? 407 ARG A CG  1 
ATOM   206  C CD  . ARG A 1 28  ? 26.68116 -4.57821  -24.81649 1.000 41.28095 ? 407 ARG A CD  1 
ATOM   207  N NE  . ARG A 1 28  ? 26.04048 -4.02722  -25.99952 1.000 45.72296 ? 407 ARG A NE  1 
ATOM   208  C CZ  . ARG A 1 28  ? 25.80799 -4.69279  -27.12467 1.000 49.77235 ? 407 ARG A CZ  1 
ATOM   209  N NH1 . ARG A 1 28  ? 26.12386 -5.97592  -27.25908 1.000 46.56784 ? 407 ARG A NH1 1 
ATOM   210  N NH2 . ARG A 1 28  ? 25.21290 -4.06080  -28.12988 1.000 53.25888 ? 407 ARG A NH2 1 
ATOM   211  N N   . ASN A 1 29  ? 22.31909 -4.63009  -21.55879 1.000 25.20336 ? 408 ASN A N   1 
ATOM   212  C CA  . ASN A 1 29  ? 21.01583 -4.32831  -20.99839 1.000 24.94131 ? 408 ASN A CA  1 
ATOM   213  C C   . ASN A 1 29  ? 21.02017 -4.86954  -19.57216 1.000 25.23355 ? 408 ASN A C   1 
ATOM   214  O O   . ASN A 1 29  ? 22.07010 -5.01336  -18.93155 1.000 23.14222 ? 408 ASN A O   1 
ATOM   215  C CB  . ASN A 1 29  ? 19.89517 -4.90272  -21.88789 1.000 25.44211 ? 408 ASN A CB  1 
ATOM   216  C CG  . ASN A 1 29  ? 20.04238 -6.40023  -22.13576 1.000 24.36845 ? 408 ASN A CG  1 
ATOM   217  O OD1 . ASN A 1 29  ? 20.31681 -7.17810  -21.21999 1.000 27.47852 ? 408 ASN A OD1 1 
ATOM   218  N ND2 . ASN A 1 29  ? 19.84069 -6.80965  -23.38139 1.000 33.52231 ? 408 ASN A ND2 1 
ATOM   219  N N   . ALA A 1 30  ? 19.84568 -5.22219  -19.06576 1.000 21.24307 ? 409 ALA A N   1 
ATOM   220  C CA  . ALA A 1 30  ? 19.75462 -5.67733  -17.68345 1.000 27.95558 ? 409 ALA A CA  1 
ATOM   221  C C   . ALA A 1 30  ? 20.42517 -7.03158  -17.46895 1.000 22.83225 ? 409 ALA A C   1 
ATOM   222  O O   . ALA A 1 30  ? 20.91641 -7.30335  -16.36913 1.000 17.24671 ? 409 ALA A O   1 
ATOM   223  C CB  . ALA A 1 30  ? 18.29086 -5.74404  -17.24821 1.000 26.83671 ? 409 ALA A CB  1 
ATOM   224  N N   . VAL A 1 31  ? 20.50111 -7.87245  -18.49938 1.000 17.77243 ? 410 VAL A N   1 
ATOM   225  C CA  . VAL A 1 31  ? 20.97320 -9.24249  -18.30704 1.000 19.96803 ? 410 VAL A CA  1 
ATOM   226  C C   . VAL A 1 31  ? 22.13787 -9.56130  -19.23520 1.000 22.81332 ? 410 VAL A C   1 
ATOM   227  O O   . VAL A 1 31  ? 23.03223 -10.33718 -18.87376 1.000 23.52759 ? 410 VAL A O   1 
ATOM   228  C CB  . VAL A 1 31  ? 19.82106 -10.25272 -18.49250 1.000 22.47830 ? 410 VAL A CB  1 
ATOM   229  C CG1 . VAL A 1 31  ? 19.22248 -10.14377 -19.88432 1.000 22.49495 ? 410 VAL A CG1 1 
ATOM   230  C CG2 . VAL A 1 31  ? 20.27681 -11.66651 -18.20063 1.000 26.43234 ? 410 VAL A CG2 1 
ATOM   231  N N   . ILE A 1 32  ? 22.14725 -8.96883  -20.42516 1.000 21.69447 ? 411 ILE A N   1 
ATOM   232  C CA  . ILE A 1 32  ? 23.18762 -9.26721  -21.40055 1.000 21.69229 ? 411 ILE A CA  1 
ATOM   233  C C   . ILE A 1 32  ? 24.45683 -8.51468  -21.02499 1.000 20.43273 ? 411 ILE A C   1 
ATOM   234  O O   . ILE A 1 32  ? 24.42305 -7.30680  -20.76298 1.000 19.94933 ? 411 ILE A O   1 
ATOM   235  C CB  . ILE A 1 32  ? 22.72153 -8.91086  -22.81901 1.000 25.31857 ? 411 ILE A CB  1 
ATOM   236  C CG1 . ILE A 1 32  ? 21.53460 -9.78936  -23.22345 1.000 25.91959 ? 411 ILE A CG1 1 
ATOM   237  C CG2 . ILE A 1 32  ? 23.86010 -9.08045  -23.81344 1.000 24.29176 ? 411 ILE A CG2 1 
ATOM   238  C CD1 . ILE A 1 32  ? 21.85714 -11.26428 -23.26058 1.000 29.25335 ? 411 ILE A CD1 1 
ATOM   239  N N   . MET A 1 33  ? 25.57933 -9.23088  -20.98675 1.000 17.78150 ? 412 MET A N   1 
ATOM   240  C CA  . MET A 1 33  ? 26.86618 -8.64814  -20.63905 1.000 19.87247 ? 412 MET A CA  1 
ATOM   241  C C   . MET A 1 33  ? 27.91934 -9.08972  -21.63986 1.000 21.35487 ? 412 MET A C   1 
ATOM   242  O O   . MET A 1 33  ? 27.81310 -10.15531 -22.25248 1.000 22.47273 ? 412 MET A O   1 
ATOM   243  C CB  . MET A 1 33  ? 27.30645 -9.04718  -19.22224 1.000 20.45107 ? 412 MET A CB  1 
ATOM   244  C CG  . MET A 1 33  ? 26.30313 -8.68489  -18.14064 1.000 26.95067 ? 412 MET A CG  1 
ATOM   245  S SD  . MET A 1 33  ? 26.98061 -8.79298  -16.47384 1.000 27.48822 ? 412 MET A SD  1 
ATOM   246  C CE  . MET A 1 33  ? 27.36475 -10.53994 -16.36325 1.000 16.31553 ? 412 MET A CE  1 
ATOM   247  N N   . GLU A 1 34  ? 28.94740 -8.26448  -21.79471 1.000 22.57462 ? 413 GLU A N   1 
ATOM   248  C CA  . GLU A 1 34  ? 30.05604 -8.53689  -22.68187 1.000 27.40598 ? 413 GLU A CA  1 
ATOM   249  C C   . GLU A 1 34  ? 31.36697 -8.24852  -21.98513 1.000 22.72264 ? 413 GLU A C   1 
ATOM   250  O O   . GLU A 1 34  ? 31.41369 -7.44674  -21.03574 1.000 19.62506 ? 413 GLU A O   1 
ATOM   251  C CB  . GLU A 1 34  ? 29.95465 -7.70634  -23.97475 1.000 30.67326 ? 413 GLU A CB  1 
ATOM   252  C CG  . GLU A 1 34  ? 30.04317 -6.20222  -23.77788 1.000 29.66978 ? 413 GLU A CG  1 
ATOM   253  C CD  . GLU A 1 34  ? 29.89915 -5.44864  -25.08811 1.000 40.94361 ? 413 GLU A CD  1 
ATOM   254  O OE1 . GLU A 1 34  ? 29.33171 -6.02701  -26.03850 1.000 45.48725 ? 413 GLU A OE1 1 
ATOM   255  O OE2 . GLU A 1 34  ? 30.35043 -4.28657  -25.17061 1.000 39.24853 ? 413 GLU A OE2 1 
ATOM   256  N N   . PRO A 1 35  ? 32.46440 -8.87817  -22.39235 1.000 22.91458 ? 414 PRO A N   1 
ATOM   257  C CA  . PRO A 1 35  ? 33.75719 -8.57037  -21.78702 1.000 19.71221 ? 414 PRO A CA  1 
ATOM   258  C C   . PRO A 1 35  ? 34.20337 -7.15827  -22.13347 1.000 25.83713 ? 414 PRO A C   1 
ATOM   259  O O   . PRO A 1 35  ? 33.89381 -6.62941  -23.20426 1.000 21.32574 ? 414 PRO A O   1 
ATOM   260  C CB  . PRO A 1 35  ? 34.69858 -9.61442  -22.39343 1.000 24.57289 ? 414 PRO A CB  1 
ATOM   261  C CG  . PRO A 1 35  ? 34.06832 -9.95678  -23.70016 1.000 28.32460 ? 414 PRO A CG  1 
ATOM   262  C CD  . PRO A 1 35  ? 32.58728 -9.92389  -23.43129 1.000 21.22539 ? 414 PRO A CD  1 
ATOM   263  N N   . TYR A 1 36  ? 34.92579 -6.54141  -21.20141 1.000 21.61109 ? 415 TYR A N   1 
ATOM   264  C CA  . TYR A 1 36  ? 35.53762 -5.24700  -21.46536 1.000 20.88721 ? 415 TYR A CA  1 
ATOM   265  C C   . TYR A 1 36  ? 36.84739 -5.16716  -20.69553 1.000 23.29374 ? 415 TYR A C   1 
ATOM   266  O O   . TYR A 1 36  ? 37.05180 -5.87489  -19.70644 1.000 22.55923 ? 415 TYR A O   1 
ATOM   267  C CB  . TYR A 1 36  ? 34.60089 -4.08393  -21.09528 1.000 22.29539 ? 415 TYR A CB  1 
ATOM   268  C CG  . TYR A 1 36  ? 34.68437 -3.64209  -19.64949 1.000 22.43435 ? 415 TYR A CG  1 
ATOM   269  C CD1 . TYR A 1 36  ? 33.99471 -4.31895  -18.65455 1.000 21.53054 ? 415 TYR A CD1 1 
ATOM   270  C CD2 . TYR A 1 36  ? 35.44300 -2.53678  -19.28236 1.000 22.61172 ? 415 TYR A CD2 1 
ATOM   271  C CE1 . TYR A 1 36  ? 34.07028 -3.91784  -17.32816 1.000 22.70309 ? 415 TYR A CE1 1 
ATOM   272  C CE2 . TYR A 1 36  ? 35.52422 -2.12758  -17.96017 1.000 24.07795 ? 415 TYR A CE2 1 
ATOM   273  C CZ  . TYR A 1 36  ? 34.83661 -2.82157  -16.98797 1.000 22.24495 ? 415 TYR A CZ  1 
ATOM   274  O OH  . TYR A 1 36  ? 34.91477 -2.41389  -15.67520 1.000 23.03239 ? 415 TYR A OH  1 
ATOM   275  N N   . MET A 1 37  ? 37.74551 -4.30993  -21.17257 1.000 24.60980 ? 416 MET A N   1 
ATOM   276  C CA  . MET A 1 37  ? 39.03160 -4.10321  -20.51970 1.000 26.89554 ? 416 MET A CA  1 
ATOM   277  C C   . MET A 1 37  ? 38.91338 -2.94971  -19.53263 1.000 25.99021 ? 416 MET A C   1 
ATOM   278  O O   . MET A 1 37  ? 38.49343 -1.84773  -19.90332 1.000 25.91326 ? 416 MET A O   1 
ATOM   279  C CB  . MET A 1 37  ? 40.12621 -3.83478  -21.54855 1.000 23.99876 ? 416 MET A CB  1 
ATOM   280  C CG  . MET A 1 37  ? 40.32243 -4.99086  -22.51169 1.000 25.42732 ? 416 MET A CG  1 
ATOM   281  S SD  . MET A 1 37  ? 40.25780 -6.60309  -21.68861 1.000 30.27615 ? 416 MET A SD  1 
ATOM   282  C CE  . MET A 1 37  ? 41.91613 -6.76333  -21.02019 1.000 27.06785 ? 416 MET A CE  1 
ATOM   283  N N   . ILE A 1 38  ? 39.27765 -3.21377  -18.27591 1.000 22.28023 ? 417 ILE A N   1 
ATOM   284  C CA  . ILE A 1 38  ? 39.12619 -2.22380  -17.21754 1.000 25.89150 ? 417 ILE A CA  1 
ATOM   285  C C   . ILE A 1 38  ? 39.98443 -1.00598  -17.52303 1.000 31.55103 ? 417 ILE A C   1 
ATOM   286  O O   . ILE A 1 38  ? 41.17995 -1.12313  -17.82067 1.000 29.26179 ? 417 ILE A O   1 
ATOM   287  C CB  . ILE A 1 38  ? 39.48514 -2.85262  -15.86475 1.000 22.79450 ? 417 ILE A CB  1 
ATOM   288  C CG1 . ILE A 1 38  ? 38.52194 -4.00265  -15.55921 1.000 24.41115 ? 417 ILE A CG1 1 
ATOM   289  C CG2 . ILE A 1 38  ? 39.47092 -1.80287  -14.76329 1.000 25.97570 ? 417 ILE A CG2 1 
ATOM   290  C CD1 . ILE A 1 38  ? 39.10290 -5.05643  -14.66014 1.000 24.77555 ? 417 ILE A CD1 1 
ATOM   291  N N   . GLU A 1 39  ? 39.37210 0.17512   -17.45305 1.000 30.85915 ? 418 GLU A N   1 
ATOM   292  C CA  . GLU A 1 39  ? 40.01292 1.42264   -17.84617 1.000 36.56199 ? 418 GLU A CA  1 
ATOM   293  C C   . GLU A 1 39  ? 40.48459 2.26439   -16.66661 1.000 31.23449 ? 418 GLU A C   1 
ATOM   294  O O   . GLU A 1 39  ? 41.04156 3.34539   -16.88367 1.000 36.75663 ? 418 GLU A O   1 
ATOM   295  C CB  . GLU A 1 39  ? 39.05411 2.25469   -18.70582 1.000 34.37277 ? 418 GLU A CB  1 
ATOM   296  C CG  . GLU A 1 39  ? 38.59754 1.57428   -19.98301 1.000 31.73081 ? 418 GLU A CG  1 
ATOM   297  C CD  . GLU A 1 39  ? 37.73871 2.48022   -20.84188 1.000 43.21683 ? 418 GLU A CD  1 
ATOM   298  O OE1 . GLU A 1 39  ? 36.69559 2.95810   -20.34785 1.000 45.51305 ? 418 GLU A OE1 1 
ATOM   299  O OE2 . GLU A 1 39  ? 38.11351 2.72512   -22.00782 1.000 56.00983 ? 418 GLU A OE2 1 
ATOM   300  N N   . ILE A 1 40  ? 40.28063 1.80673   -15.43038 1.000 27.38600 ? 419 ILE A N   1 
ATOM   301  C CA  . ILE A 1 40  ? 40.55006 2.61036   -14.24504 1.000 27.58288 ? 419 ILE A CA  1 
ATOM   302  C C   . ILE A 1 40  ? 41.41761 1.81813   -13.27208 1.000 29.17067 ? 419 ILE A C   1 
ATOM   303  O O   . ILE A 1 40  ? 41.62125 0.61291   -13.41842 1.000 31.51046 ? 419 ILE A O   1 
ATOM   304  C CB  . ILE A 1 40  ? 39.25134 3.08111   -13.55453 1.000 29.11711 ? 419 ILE A CB  1 
ATOM   305  C CG1 . ILE A 1 40  ? 38.34343 1.89166   -13.23105 1.000 26.97258 ? 419 ILE A CG1 1 
ATOM   306  C CG2 . ILE A 1 40  ? 38.51213 4.08313   -14.42849 1.000 27.84613 ? 419 ILE A CG2 1 
ATOM   307  C CD1 . ILE A 1 40  ? 38.40197 1.44251   -11.78543 1.000 31.09035 ? 419 ILE A CD1 1 
ATOM   308  N N   . ASP A 1 41  ? 41.92454 2.52610   -12.26230 1.000 30.07479 ? 420 ASP A N   1 
ATOM   309  C CA  . ASP A 1 41  ? 42.78823 1.94653   -11.23639 1.000 34.54673 ? 420 ASP A CA  1 
ATOM   310  C C   . ASP A 1 41  ? 41.92512 1.18549   -10.23695 1.000 33.27225 ? 420 ASP A C   1 
ATOM   311  O O   . ASP A 1 41  ? 41.25652 1.79186   -9.39318  1.000 36.65282 ? 420 ASP A O   1 
ATOM   312  C CB  . ASP A 1 41  ? 43.59390 3.05119   -10.55482 1.000 28.89565 ? 420 ASP A CB  1 
ATOM   313  C CG  . ASP A 1 41  ? 44.57119 2.52822   -9.51258  1.000 33.50026 ? 420 ASP A CG  1 
ATOM   314  O OD1 . ASP A 1 41  ? 44.56424 1.31821   -9.20034  1.000 30.50103 ? 420 ASP A OD1 1 
ATOM   315  O OD2 . ASP A 1 41  ? 45.36024 3.34895   -8.99857  1.000 34.26337 ? 420 ASP A OD2 1 
ATOM   316  N N   . ASN A 1 42  ? 41.95601 -0.14693  -10.31528 1.000 33.05464 ? 421 ASN A N   1 
ATOM   317  C CA  . ASN A 1 42  ? 41.15964 -1.00211  -9.44276  1.000 35.56423 ? 421 ASN A CA  1 
ATOM   318  C C   . ASN A 1 42  ? 41.91664 -1.44446  -8.19256  1.000 32.45574 ? 421 ASN A C   1 
ATOM   319  O O   . ASN A 1 42  ? 41.66491 -2.54098  -7.67497  1.000 28.34294 ? 421 ASN A O   1 
ATOM   320  C CB  . ASN A 1 42  ? 40.65412 -2.21895  -10.22010 1.000 32.27251 ? 421 ASN A CB  1 
ATOM   321  C CG  . ASN A 1 42  ? 41.77948 -3.05119  -10.79457 1.000 35.20388 ? 421 ASN A CG  1 
ATOM   322  O OD1 . ASN A 1 42  ? 42.88276 -2.55314  -11.02390 1.000 41.71860 ? 421 ASN A OD1 1 
ATOM   323  N ND2 . ASN A 1 42  ? 41.50701 -4.32902  -11.03108 1.000 40.32367 ? 421 ASN A ND2 1 
ATOM   324  N N   . SER A 1 43  ? 42.84128 -0.62589  -7.69472  1.000 30.31792 ? 422 SER A N   1 
ATOM   325  C CA  . SER A 1 43  ? 43.54070 -0.90330  -6.44788  1.000 26.78405 ? 422 SER A CA  1 
ATOM   326  C C   . SER A 1 43  ? 43.07161 -0.01536  -5.30538  1.000 28.41759 ? 422 SER A C   1 
ATOM   327  O O   . SER A 1 43  ? 43.54225 -0.18022  -4.17629  1.000 30.05756 ? 422 SER A O   1 
ATOM   328  C CB  . SER A 1 43  ? 45.05240 -0.73303  -6.63658  1.000 34.19451 ? 422 SER A CB  1 
ATOM   329  O OG  . SER A 1 43  ? 45.39292 0.63229   -6.79686  1.000 28.80126 ? 422 SER A OG  1 
ATOM   330  N N   . MET A 1 44  ? 42.15895 0.91477   -5.56994  1.000 31.80297 ? 423 MET A N   1 
ATOM   331  C CA  . MET A 1 44  ? 41.79144 1.94310   -4.60776  1.000 25.07590 ? 423 MET A CA  1 
ATOM   332  C C   . MET A 1 44  ? 40.67625 1.46655   -3.68882  1.000 33.57843 ? 423 MET A C   1 
ATOM   333  O O   . MET A 1 44  ? 39.74502 0.78191   -4.12258  1.000 24.67919 ? 423 MET A O   1 
ATOM   334  C CB  . MET A 1 44  ? 41.34962 3.21557   -5.33243  1.000 28.29178 ? 423 MET A CB  1 
ATOM   335  C CG  . MET A 1 44  ? 42.43592 3.85689   -6.18610  1.000 30.88122 ? 423 MET A CG  1 
ATOM   336  S SD  . MET A 1 44  ? 43.72364 4.60656   -5.16659  1.000 40.48013 ? 423 MET A SD  1 
ATOM   337  C CE  . MET A 1 44  ? 45.19218 3.79738   -5.79375  1.000 36.98898 ? 423 MET A CE  1 
ATOM   338  N N   . GLU A 1 45  ? 40.77785 1.84643   -2.41189  1.000 29.83328 ? 424 GLU A N   1 
ATOM   339  C CA  . GLU A 1 45  ? 39.71074 1.56226   -1.45971  1.000 28.41849 ? 424 GLU A CA  1 
ATOM   340  C C   . GLU A 1 45  ? 38.41688 2.26031   -1.85576  1.000 30.76120 ? 424 GLU A C   1 
ATOM   341  O O   . GLU A 1 45  ? 37.32617 1.73282   -1.61338  1.000 28.67707 ? 424 GLU A O   1 
ATOM   342  C CB  . GLU A 1 45  ? 40.14742 1.98877   -0.05678  1.000 37.13544 ? 424 GLU A CB  1 
ATOM   343  C CG  . GLU A 1 45  ? 39.78808 1.00614   1.04825   1.000 39.96987 ? 424 GLU A CG  1 
ATOM   344  C CD  . GLU A 1 45  ? 38.35281 1.15789   1.51997   1.000 42.93594 ? 424 GLU A CD  1 
ATOM   345  O OE1 . GLU A 1 45  ? 37.81149 2.28212   1.43756   1.000 53.74970 ? 424 GLU A OE1 1 
ATOM   346  O OE2 . GLU A 1 45  ? 37.75866 0.15351   1.97097   1.000 48.04970 ? 424 GLU A OE2 1 
ATOM   347  N N   . GLN A 1 46  ? 38.51751 3.43437   -2.47529  1.000 25.91543 ? 425 GLN A N   1 
ATOM   348  C CA  . GLN A 1 46  ? 37.36127 4.20483   -2.91629  1.000 23.50149 ? 425 GLN A CA  1 
ATOM   349  C C   . GLN A 1 46  ? 37.54612 4.55796   -4.38317  1.000 28.78836 ? 425 GLN A C   1 
ATOM   350  O O   . GLN A 1 46  ? 38.57433 5.13075   -4.75891  1.000 29.89890 ? 425 GLN A O   1 
ATOM   351  C CB  . GLN A 1 46  ? 37.18929 5.47567   -2.07948  1.000 24.68910 ? 425 GLN A CB  1 
ATOM   352  C CG  . GLN A 1 46  ? 36.19342 6.46564   -2.65931  1.000 24.36514 ? 425 GLN A CG  1 
ATOM   353  C CD  . GLN A 1 46  ? 34.75273 6.04568   -2.44447  1.000 25.91685 ? 425 GLN A CD  1 
ATOM   354  O OE1 . GLN A 1 46  ? 34.32220 5.82227   -1.31238  1.000 25.19799 ? 425 GLN A OE1 1 
ATOM   355  N NE2 . GLN A 1 46  ? 33.99748 5.93831   -3.53317  1.000 22.56609 ? 425 GLN A NE2 1 
ATOM   356  N N   . LEU A 1 47  ? 36.56183 4.21209   -5.20647  1.000 20.34767 ? 426 LEU A N   1 
ATOM   357  C CA  . LEU A 1 47  ? 36.59604 4.53848   -6.62303  1.000 22.68461 ? 426 LEU A CA  1 
ATOM   358  C C   . LEU A 1 47  ? 35.89537 5.86908   -6.87752  1.000 24.84432 ? 426 LEU A C   1 
ATOM   359  O O   . LEU A 1 47  ? 35.05307 6.31742   -6.09689  1.000 25.22927 ? 426 LEU A O   1 
ATOM   360  C CB  . LEU A 1 47  ? 35.94086 3.43347   -7.45458  1.000 25.62170 ? 426 LEU A CB  1 
ATOM   361  C CG  . LEU A 1 47  ? 36.59363 2.04798   -7.44648  1.000 22.76613 ? 426 LEU A CG  1 
ATOM   362  C CD1 . LEU A 1 47  ? 35.83654 1.09832   -8.36729  1.000 17.49130 ? 426 LEU A CD1 1 
ATOM   363  C CD2 . LEU A 1 47  ? 38.06260 2.12499   -7.84368  1.000 26.26322 ? 426 LEU A CD2 1 
ATOM   364  N N   . SER A 1 48  ? 36.25075 6.49603   -7.99446  1.000 27.12556 ? 427 SER A N   1 
ATOM   365  C CA  . SER A 1 48  ? 35.67645 7.78761   -8.34045  1.000 22.88998 ? 427 SER A CA  1 
ATOM   366  C C   . SER A 1 48  ? 34.24358 7.63260   -8.84195  1.000 29.29164 ? 427 SER A C   1 
ATOM   367  O O   . SER A 1 48  ? 33.87156 6.61351   -9.43086  1.000 23.20180 ? 427 SER A O   1 
ATOM   368  C CB  . SER A 1 48  ? 36.52708 8.48124   -9.40373  1.000 22.16937 ? 427 SER A CB  1 
ATOM   369  O OG  . SER A 1 48  ? 35.84287 9.59549   -9.94921  1.000 30.17710 ? 427 SER A OG  1 
ATOM   370  N N   . PHE A 1 49  ? 33.43729 8.66932   -8.60922  1.000 23.24031 ? 428 PHE A N   1 
ATOM   371  C CA  . PHE A 1 49  ? 32.04330 8.67911   -9.03644  1.000 25.03396 ? 428 PHE A CA  1 
ATOM   372  C C   . PHE A 1 49  ? 31.85142 9.18670   -10.46057 1.000 28.08169 ? 428 PHE A C   1 
ATOM   373  O O   . PHE A 1 49  ? 30.70525 9.26860   -10.91432 1.000 32.16456 ? 428 PHE A O   1 
ATOM   374  C CB  . PHE A 1 49  ? 31.19711 9.54051   -8.09183  1.000 27.36677 ? 428 PHE A CB  1 
ATOM   375  C CG  . PHE A 1 49  ? 30.93696 8.91579   -6.74678  1.000 29.40291 ? 428 PHE A CG  1 
ATOM   376  C CD1 . PHE A 1 49  ? 31.29123 7.60198   -6.48196  1.000 25.63904 ? 428 PHE A CD1 1 
ATOM   377  C CD2 . PHE A 1 49  ? 30.31612 9.64927   -5.74865  1.000 28.56051 ? 428 PHE A CD2 1 
ATOM   378  C CE1 . PHE A 1 49  ? 31.04235 7.04020   -5.24088  1.000 28.05905 ? 428 PHE A CE1 1 
ATOM   379  C CE2 . PHE A 1 49  ? 30.06334 9.09209   -4.51108  1.000 29.19026 ? 428 PHE A CE2 1 
ATOM   380  C CZ  . PHE A 1 49  ? 30.42681 7.78688   -4.25659  1.000 30.68671 ? 428 PHE A CZ  1 
ATOM   381  N N   . ASP A 1 50  ? 32.92215 9.53603   -11.17578 1.000 25.62119 ? 429 ASP A N   1 
ATOM   382  C CA  . ASP A 1 50  ? 32.79701 10.09770  -12.51461 1.000 29.27204 ? 429 ASP A CA  1 
ATOM   383  C C   . ASP A 1 50  ? 32.94490 9.04557   -13.61004 1.000 29.03263 ? 429 ASP A C   1 
ATOM   384  O O   . ASP A 1 50  ? 33.22662 9.39301   -14.76185 1.000 32.76483 ? 429 ASP A O   1 
ATOM   385  C CB  . ASP A 1 50  ? 33.80415 11.23301  -12.71486 1.000 28.05487 ? 429 ASP A CB  1 
ATOM   386  C CG  . ASP A 1 50  ? 35.22401 10.73847  -12.90648 1.000 34.64219 ? 429 ASP A CG  1 
ATOM   387  O OD1 . ASP A 1 50  ? 35.62429 9.76900   -12.22954 1.000 30.06680 ? 429 ASP A OD1 1 
ATOM   388  O OD2 . ASP A 1 50  ? 35.94230 11.32583  -13.74286 1.000 35.19665 ? 429 ASP A OD2 1 
ATOM   389  N N   . HIS A 1 51  ? 32.75988 7.77134   -13.27204 1.000 31.20006 ? 430 HIS A N   1 
ATOM   390  C CA  . HIS A 1 51  ? 32.66861 6.70050   -14.25461 1.000 29.17825 ? 430 HIS A CA  1 
ATOM   391  C C   . HIS A 1 51  ? 31.71496 5.64661   -13.70931 1.000 27.58735 ? 430 HIS A C   1 
ATOM   392  O O   . HIS A 1 51  ? 31.26659 5.72556   -12.56340 1.000 26.38194 ? 430 HIS A O   1 
ATOM   393  C CB  . HIS A 1 51  ? 34.04377 6.10238   -14.57712 1.000 27.25242 ? 430 HIS A CB  1 
ATOM   394  C CG  . HIS A 1 51  ? 34.76069 5.54909   -13.38479 1.000 26.84785 ? 430 HIS A CG  1 
ATOM   395  N ND1 . HIS A 1 51  ? 34.36067 4.39846   -12.74016 1.000 22.77112 ? 430 HIS A ND1 1 
ATOM   396  C CD2 . HIS A 1 51  ? 35.85617 5.98990   -12.72235 1.000 28.38465 ? 430 HIS A CD2 1 
ATOM   397  C CE1 . HIS A 1 51  ? 35.17648 4.15615   -11.72934 1.000 23.40902 ? 430 HIS A CE1 1 
ATOM   398  N NE2 . HIS A 1 51  ? 36.09166 5.10767   -11.69598 1.000 24.69917 ? 430 HIS A NE2 1 
ATOM   399  N N   . ASP A 1 52  ? 31.40448 4.64941   -14.54060 1.000 26.61991 ? 431 ASP A N   1 
ATOM   400  C CA  . ASP A 1 52  ? 30.42705 3.62556   -14.18720 1.000 27.32748 ? 431 ASP A CA  1 
ATOM   401  C C   . ASP A 1 52  ? 31.05202 2.23981   -14.03364 1.000 23.78370 ? 431 ASP A C   1 
ATOM   402  O O   . ASP A 1 52  ? 30.40286 1.22956   -14.31456 1.000 22.55787 ? 431 ASP A O   1 
ATOM   403  C CB  . ASP A 1 52  ? 29.29370 3.58475   -15.21339 1.000 25.34348 ? 431 ASP A CB  1 
ATOM   404  C CG  . ASP A 1 52  ? 29.77082 3.21888   -16.61136 1.000 23.78488 ? 431 ASP A CG  1 
ATOM   405  O OD1 . ASP A 1 52  ? 30.99683 3.15861   -16.84245 1.000 29.30970 ? 431 ASP A OD1 1 
ATOM   406  O OD2 . ASP A 1 52  ? 28.90740 2.98870   -17.48454 1.000 25.62000 ? 431 ASP A OD2 1 
ATOM   407  N N   . GLU A 1 53  ? 32.30238 2.17279   -13.58280 1.000 20.43671 ? 432 GLU A N   1 
ATOM   408  C CA  . GLU A 1 53  ? 32.96501 0.90607   -13.29466 1.000 21.28742 ? 432 GLU A CA  1 
ATOM   409  C C   . GLU A 1 53  ? 32.94484 0.67444   -11.78925 1.000 21.90088 ? 432 GLU A C   1 
ATOM   410  O O   . GLU A 1 53  ? 33.46774 1.49508   -11.02749 1.000 23.08216 ? 432 GLU A O   1 
ATOM   411  C CB  . GLU A 1 53  ? 34.40493 0.89996   -13.80816 1.000 20.02914 ? 432 GLU A CB  1 
ATOM   412  C CG  . GLU A 1 53  ? 34.55517 1.09428   -15.30584 1.000 22.70157 ? 432 GLU A CG  1 
ATOM   413  C CD  . GLU A 1 53  ? 35.94336 0.73001   -15.80087 1.000 28.35961 ? 432 GLU A CD  1 
ATOM   414  O OE1 . GLU A 1 53  ? 36.47618 -0.31684  -15.37256 1.000 25.82157 ? 432 GLU A OE1 1 
ATOM   415  O OE2 . GLU A 1 53  ? 36.50748 1.49296   -16.61223 1.000 33.10800 ? 432 GLU A OE2 1 
ATOM   416  N N   . SER A 1 54  ? 32.35405 -0.43998  -11.36256 1.000 22.21430 ? 433 SER A N   1 
ATOM   417  C CA  . SER A 1 54  ? 32.26226 -0.78178  -9.95184  1.000 20.01013 ? 433 SER A CA  1 
ATOM   418  C C   . SER A 1 54  ? 32.92746 -2.12782  -9.69736  1.000 17.28834 ? 433 SER A C   1 
ATOM   419  O O   . SER A 1 54  ? 32.93494 -3.00548  -10.56392 1.000 18.46193 ? 433 SER A O   1 
ATOM   420  C CB  . SER A 1 54  ? 30.79606 -0.83374  -9.48681  1.000 22.29860 ? 433 SER A CB  1 
ATOM   421  O OG  . SER A 1 54  ? 30.12719 0.38528   -9.75798  1.000 21.30469 ? 433 SER A OG  1 
ATOM   422  N N   . TYR A 1 55  ? 33.51059 -2.27625  -8.50785  1.000 15.28364 ? 434 TYR A N   1 
ATOM   423  C CA  . TYR A 1 55  ? 33.95879 -3.58438  -8.05133  1.000 19.59914 ? 434 TYR A CA  1 
ATOM   424  C C   . TYR A 1 55  ? 32.79010 -4.55920  -8.01452  1.000 20.03195 ? 434 TYR A C   1 
ATOM   425  O O   . TYR A 1 55  ? 31.68398 -4.20321  -7.59109  1.000 17.31054 ? 434 TYR A O   1 
ATOM   426  C CB  . TYR A 1 55  ? 34.55390 -3.48573  -6.64619  1.000 19.43833 ? 434 TYR A CB  1 
ATOM   427  C CG  . TYR A 1 55  ? 35.85675 -2.73121  -6.52894  1.000 21.17275 ? 434 TYR A CG  1 
ATOM   428  C CD1 . TYR A 1 55  ? 36.93887 -3.03821  -7.34010  1.000 20.64002 ? 434 TYR A CD1 1 
ATOM   429  C CD2 . TYR A 1 55  ? 36.01006 -1.72001  -5.58953  1.000 21.13693 ? 434 TYR A CD2 1 
ATOM   430  C CE1 . TYR A 1 55  ? 38.13822 -2.35330  -7.22583  1.000 19.90621 ? 434 TYR A CE1 1 
ATOM   431  C CE2 . TYR A 1 55  ? 37.20672 -1.02920  -5.46713  1.000 21.97560 ? 434 TYR A CE2 1 
ATOM   432  C CZ  . TYR A 1 55  ? 38.26494 -1.35166  -6.28807  1.000 23.64240 ? 434 TYR A CZ  1 
ATOM   433  O OH  . TYR A 1 55  ? 39.45616 -0.66916  -6.17205  1.000 23.60997 ? 434 TYR A OH  1 
ATOM   434  N N   . LEU A 1 56  ? 33.05017 -5.80277  -8.42882  1.000 20.71553 ? 435 LEU A N   1 
ATOM   435  C CA  . LEU A 1 56  ? 32.10543 -6.90391  -8.27475  1.000 16.91370 ? 435 LEU A CA  1 
ATOM   436  C C   . LEU A 1 56  ? 32.86459 -8.10879  -7.73897  1.000 22.58224 ? 435 LEU A C   1 
ATOM   437  O O   . LEU A 1 56  ? 33.81298 -8.58421  -8.36957  1.000 17.46250 ? 435 LEU A O   1 
ATOM   438  C CB  . LEU A 1 56  ? 31.41131 -7.25125  -9.60029  1.000 18.86758 ? 435 LEU A CB  1 
ATOM   439  C CG  . LEU A 1 56  ? 30.17276 -8.17113  -9.55914  1.000 27.14544 ? 435 LEU A CG  1 
ATOM   440  C CD1 . LEU A 1 56  ? 29.40189 -8.06115  -10.85944 1.000 28.72502 ? 435 LEU A CD1 1 
ATOM   441  C CD2 . LEU A 1 56  ? 30.50385 -9.63778  -9.29039  1.000 22.97230 ? 435 LEU A CD2 1 
ATOM   442  N N   . THR A 1 57  ? 32.43232 -8.61033  -6.58798  1.000 17.75114 ? 436 THR A N   1 
ATOM   443  C CA  . THR A 1 57  ? 32.95580 -9.83210  -5.99792  1.000 18.88297 ? 436 THR A CA  1 
ATOM   444  C C   . THR A 1 57  ? 31.82434 -10.84046 -5.87536  1.000 19.09249 ? 436 THR A C   1 
ATOM   445  O O   . THR A 1 57  ? 30.76726 -10.53026 -5.31775  1.000 15.88838 ? 436 THR A O   1 
ATOM   446  C CB  . THR A 1 57  ? 33.57397 -9.57054  -4.62113  1.000 19.93499 ? 436 THR A CB  1 
ATOM   447  O OG1 . THR A 1 57  ? 34.56982 -8.54817  -4.73031  1.000 21.08480 ? 436 THR A OG1 1 
ATOM   448  C CG2 . THR A 1 57  ? 34.21738 -10.83657 -4.08085  1.000 19.43309 ? 436 THR A CG2 1 
ATOM   449  N N   . MET A 1 58  ? 32.04116 -12.03604 -6.40692  1.000 14.68587 ? 437 MET A N   1 
ATOM   450  C CA  . MET A 1 58  ? 31.13572 -13.15628 -6.20246  1.000 18.24498 ? 437 MET A CA  1 
ATOM   451  C C   . MET A 1 58  ? 31.78607 -14.11974 -5.22431  1.000 20.59214 ? 437 MET A C   1 
ATOM   452  O O   . MET A 1 58  ? 32.94824 -14.48916 -5.39706  1.000 15.97050 ? 437 MET A O   1 
ATOM   453  C CB  . MET A 1 58  ? 30.81772 -13.86212 -7.51919  1.000 21.52664 ? 437 MET A CB  1 
ATOM   454  C CG  . MET A 1 58  ? 29.85001 -15.02510 -7.37337  1.000 21.97346 ? 437 MET A CG  1 
ATOM   455  S SD  . MET A 1 58  ? 28.12417 -14.49759 -7.28546  1.000 41.23344 ? 437 MET A SD  1 
ATOM   456  C CE  . MET A 1 58  ? 27.88562 -13.86737 -8.95210  1.000 22.00688 ? 437 MET A CE  1 
ATOM   457  N N   . LEU A 1 59  ? 31.04462 -14.51382 -4.19812  1.000 16.03389 ? 438 LEU A N   1 
ATOM   458  C CA  . LEU A 1 59  ? 31.57292 -15.34458 -3.12904  1.000 19.98970 ? 438 LEU A CA  1 
ATOM   459  C C   . LEU A 1 59  ? 30.76240 -16.62577 -3.02751  1.000 19.11776 ? 438 LEU A C   1 
ATOM   460  O O   . LEU A 1 59  ? 29.52773 -16.58418 -2.98650  1.000 18.90904 ? 438 LEU A O   1 
ATOM   461  C CB  . LEU A 1 59  ? 31.55578 -14.59209 -1.79696  1.000 17.43865 ? 438 LEU A CB  1 
ATOM   462  C CG  . LEU A 1 59  ? 32.41577 -13.32666 -1.75849  1.000 20.60780 ? 438 LEU A CG  1 
ATOM   463  C CD1 . LEU A 1 59  ? 31.56570 -12.11571 -1.43506  1.000 23.80097 ? 438 LEU A CD1 1 
ATOM   464  C CD2 . LEU A 1 59  ? 33.55636 -13.46780 -0.76256  1.000 27.71584 ? 438 LEU A CD2 1 
ATOM   465  N N   . ASP A 1 60  ? 31.46581 -17.75516 -3.00796  1.000 20.25593 ? 439 ASP A N   1 
ATOM   466  C CA  . ASP A 1 60  ? 30.85511 -19.04069 -2.70463  1.000 22.04203 ? 439 ASP A CA  1 
ATOM   467  C C   . ASP A 1 60  ? 30.05421 -18.94840 -1.41368  1.000 23.55724 ? 439 ASP A C   1 
ATOM   468  O O   . ASP A 1 60  ? 30.53160 -18.40500 -0.41410  1.000 19.21072 ? 439 ASP A O   1 
ATOM   469  C CB  . ASP A 1 60  ? 31.95145 -20.10098 -2.57353  1.000 19.52553 ? 439 ASP A CB  1 
ATOM   470  C CG  . ASP A 1 60  ? 31.40720 -21.48050 -2.25763  1.000 22.83455 ? 439 ASP A CG  1 
ATOM   471  O OD1 . ASP A 1 60  ? 30.20059 -21.72333 -2.47565  1.000 21.22036 ? 439 ASP A OD1 1 
ATOM   472  O OD2 . ASP A 1 60  ? 32.19554 -22.32978 -1.78663  1.000 26.59115 ? 439 ASP A OD2 1 
ATOM   473  N N   . ARG A 1 61  ? 28.82335 -19.46915 -1.44029  1.000 20.42253 ? 440 ARG A N   1 
ATOM   474  C CA  . ARG A 1 61  ? 28.04023 -19.53339 -0.21058  1.000 24.48588 ? 440 ARG A CA  1 
ATOM   475  C C   . ARG A 1 61  ? 28.77043 -20.33710 0.85557   1.000 23.95670 ? 440 ARG A C   1 
ATOM   476  O O   . ARG A 1 61  ? 28.62554 -20.06501 2.05299   1.000 24.18790 ? 440 ARG A O   1 
ATOM   477  C CB  . ARG A 1 61  ? 26.66063 -20.14259 -0.48017  1.000 23.17127 ? 440 ARG A CB  1 
ATOM   478  C CG  . ARG A 1 61  ? 25.72806 -20.10684 0.72953   1.000 26.04494 ? 440 ARG A CG  1 
ATOM   479  C CD  . ARG A 1 61  ? 24.33662 -20.62418 0.40516   1.000 23.17617 ? 440 ARG A CD  1 
ATOM   480  N NE  . ARG A 1 61  ? 23.40837 -20.42385 1.51300   1.000 24.31684 ? 440 ARG A NE  1 
ATOM   481  C CZ  . ARG A 1 61  ? 22.68419 -19.32544 1.69147   1.000 29.59516 ? 440 ARG A CZ  1 
ATOM   482  N NH1 . ARG A 1 61  ? 22.74514 -18.30886 0.84550   1.000 23.72867 ? 440 ARG A NH1 1 
ATOM   483  N NH2 . ARG A 1 61  ? 21.88096 -19.24070 2.74717   1.000 28.77224 ? 440 ARG A NH2 1 
ATOM   484  N N   . HIS A 1 62  ? 29.57157 -21.31554 0.43806   1.000 25.41692 ? 441 HIS A N   1 
ATOM   485  C CA  . HIS A 1 62  ? 30.34666 -22.15146 1.34250   1.000 26.78859 ? 441 HIS A CA  1 
ATOM   486  C C   . HIS A 1 62  ? 31.75183 -21.61012 1.59030   1.000 27.19473 ? 441 HIS A C   1 
ATOM   487  O O   . HIS A 1 62  ? 32.52362 -22.23673 2.32341   1.000 26.95610 ? 441 HIS A O   1 
ATOM   488  C CB  . HIS A 1 62  ? 30.41223 -23.57960 0.79213   1.000 30.60536 ? 441 HIS A CB  1 
ATOM   489  C CG  . HIS A 1 62  ? 29.06796 -24.16608 0.48234   1.000 35.19471 ? 441 HIS A CG  1 
ATOM   490  N ND1 . HIS A 1 62  ? 28.08641 -24.32697 1.43752   1.000 37.08754 ? 441 HIS A ND1 1 
ATOM   491  C CD2 . HIS A 1 62  ? 28.54016 -24.62652 -0.67715  1.000 32.88675 ? 441 HIS A CD2 1 
ATOM   492  C CE1 . HIS A 1 62  ? 27.01405 -24.86112 0.88088   1.000 36.72209 ? 441 HIS A CE1 1 
ATOM   493  N NE2 . HIS A 1 62  ? 27.26342 -25.05286 -0.40231  1.000 43.01687 ? 441 HIS A NE2 1 
ATOM   494  N N   . GLY A 1 63  ? 32.10154 -20.46718 1.00030   1.000 26.90971 ? 442 GLY A N   1 
ATOM   495  C CA  . GLY A 1 63  ? 33.32606 -19.76593 1.33138   1.000 25.02781 ? 442 GLY A CA  1 
ATOM   496  C C   . GLY A 1 63  ? 34.59803 -20.33103 0.74420   1.000 23.11558 ? 442 GLY A C   1 
ATOM   497  O O   . GLY A 1 63  ? 35.68733 -19.91243 1.15834   1.000 27.38051 ? 442 GLY A O   1 
ATOM   498  N N   . LYS A 1 64  ? 34.50648 -21.25218 -0.21259  1.000 20.35973 ? 443 LYS A N   1 
ATOM   499  C CA  . LYS A 1 64  ? 35.71864 -21.85476 -0.75294  1.000 26.12136 ? 443 LYS A CA  1 
ATOM   500  C C   . LYS A 1 64  ? 36.35031 -20.98415 -1.83200  1.000 27.07541 ? 443 LYS A C   1 
ATOM   501  O O   . LYS A 1 64  ? 37.57918 -20.86523 -1.89422  1.000 26.75715 ? 443 LYS A O   1 
ATOM   502  C CB  . LYS A 1 64  ? 35.41234 -23.24748 -1.30351  1.000 23.85423 ? 443 LYS A CB  1 
ATOM   503  C CG  . LYS A 1 64  ? 34.62739 -24.12502 -0.34122  1.000 28.07812 ? 443 LYS A CG  1 
ATOM   504  C CD  . LYS A 1 64  ? 35.26503 -24.11660 1.04087   1.000 34.70731 ? 443 LYS A CD  1 
ATOM   505  C CE  . LYS A 1 64  ? 34.64478 -25.17426 1.94268   1.000 36.05755 ? 443 LYS A CE  1 
ATOM   506  N NZ  . LYS A 1 64  ? 35.68772 -25.87016 2.74399   1.000 36.84524 ? 443 LYS A NZ  1 
ATOM   507  N N   . TRP A 1 65  ? 35.53476 -20.36934 -2.68505  1.000 23.50657 ? 444 TRP A N   1 
ATOM   508  C CA  . TRP A 1 65  ? 36.03169 -19.63216 -3.83533  1.000 22.37153 ? 444 TRP A CA  1 
ATOM   509  C C   . TRP A 1 65  ? 35.42426 -18.23770 -3.87624  1.000 22.86863 ? 444 TRP A C   1 
ATOM   510  O O   . TRP A 1 65  ? 34.41655 -17.95031 -3.22457  1.000 21.68168 ? 444 TRP A O   1 
ATOM   511  C CB  . TRP A 1 65  ? 35.72545 -20.36728 -5.15311  1.000 22.58553 ? 444 TRP A CB  1 
ATOM   512  C CG  . TRP A 1 65  ? 34.25979 -20.63567 -5.37455  1.000 24.12957 ? 444 TRP A CG  1 
ATOM   513  C CD1 . TRP A 1 65  ? 33.59141 -21.79148 -5.09369  1.000 24.89209 ? 444 TRP A CD1 1 
ATOM   514  C CD2 . TRP A 1 65  ? 33.28448 -19.73315 -5.92244  1.000 22.83967 ? 444 TRP A CD2 1 
ATOM   515  N NE1 . TRP A 1 65  ? 32.26738 -21.66799 -5.43132  1.000 24.07264 ? 444 TRP A NE1 1 
ATOM   516  C CE2 . TRP A 1 65  ? 32.05156 -20.41423 -5.93999  1.000 23.95964 ? 444 TRP A CE2 1 
ATOM   517  C CE3 . TRP A 1 65  ? 33.33439 -18.41895 -6.39947  1.000 22.30776 ? 444 TRP A CE3 1 
ATOM   518  C CZ2 . TRP A 1 65  ? 30.87751 -19.82401 -6.41004  1.000 22.19255 ? 444 TRP A CZ2 1 
ATOM   519  C CZ3 . TRP A 1 65  ? 32.16628 -17.83581 -6.86597  1.000 22.40360 ? 444 TRP A CZ3 1 
ATOM   520  C CH2 . TRP A 1 65  ? 30.95725 -18.53819 -6.86867  1.000 23.23153 ? 444 TRP A CH2 1 
ATOM   521  N N   . ARG A 1 66  ? 36.06084 -17.37318 -4.66384  1.000 19.70609 ? 445 ARG A N   1 
ATOM   522  C CA  . ARG A 1 66  ? 35.53818 -16.04762 -4.95269  1.000 19.93440 ? 445 ARG A CA  1 
ATOM   523  C C   . ARG A 1 66  ? 36.07376 -15.59662 -6.30384  1.000 22.04045 ? 445 ARG A C   1 
ATOM   524  O O   . ARG A 1 66  ? 37.10968 -16.07077 -6.77759  1.000 20.54506 ? 445 ARG A O   1 
ATOM   525  C CB  . ARG A 1 66  ? 35.91085 -15.03254 -3.86577  1.000 22.98873 ? 445 ARG A CB  1 
ATOM   526  C CG  . ARG A 1 66  ? 37.36424 -14.60033 -3.90744  1.000 27.10632 ? 445 ARG A CG  1 
ATOM   527  C CD  . ARG A 1 66  ? 37.63123 -13.43523 -2.97175  1.000 23.74225 ? 445 ARG A CD  1 
ATOM   528  N NE  . ARG A 1 66  ? 39.00012 -12.95775 -3.11820  1.000 30.53423 ? 445 ARG A NE  1 
ATOM   529  C CZ  . ARG A 1 66  ? 40.02392 -13.39174 -2.39716  1.000 30.68737 ? 445 ARG A CZ  1 
ATOM   530  N NH1 . ARG A 1 66  ? 39.86077 -14.28257 -1.43344  1.000 28.88800 ? 445 ARG A NH1 1 
ATOM   531  N NH2 . ARG A 1 66  ? 41.24131 -12.91946 -2.64865  1.000 31.89711 ? 445 ARG A NH2 1 
ATOM   532  N N   . VAL A 1 67  ? 35.33727 -14.68149 -6.92475  1.000 18.54819 ? 446 VAL A N   1 
ATOM   533  C CA  . VAL A 1 67  ? 35.70930 -14.06284 -8.19059  1.000 19.90894 ? 446 VAL A CA  1 
ATOM   534  C C   . VAL A 1 67  ? 35.72243 -12.55597 -7.98512  1.000 22.06623 ? 446 VAL A C   1 
ATOM   535  O O   . VAL A 1 67  ? 34.72490 -11.98037 -7.53405  1.000 20.17594 ? 446 VAL A O   1 
ATOM   536  C CB  . VAL A 1 67  ? 34.73919 -14.44952 -9.32239  1.000 20.63862 ? 446 VAL A CB  1 
ATOM   537  C CG1 . VAL A 1 67  ? 35.15851 -13.79740 -10.64058 1.000 18.53682 ? 446 VAL A CG1 1 
ATOM   538  C CG2 . VAL A 1 67  ? 34.64544 -15.96135 -9.45479  1.000 17.93261 ? 446 VAL A CG2 1 
ATOM   539  N N   . ASN A 1 68  ? 36.84873 -11.92333 -8.30937  1.000 18.07365 ? 447 ASN A N   1 
ATOM   540  C CA  . ASN A 1 68  ? 37.02687 -10.48276 -8.15486  1.000 18.91009 ? 447 ASN A CA  1 
ATOM   541  C C   . ASN A 1 68  ? 37.16657 -9.86096  -9.54052  1.000 22.02262 ? 447 ASN A C   1 
ATOM   542  O O   . ASN A 1 68  ? 38.19887 -10.04788 -10.20084 1.000 24.74100 ? 447 ASN A O   1 
ATOM   543  C CB  . ASN A 1 68  ? 38.24550 -10.16531 -7.28916  1.000 22.94748 ? 447 ASN A CB  1 
ATOM   544  C CG  . ASN A 1 68  ? 38.05507 -10.55808 -5.83810  1.000 24.76791 ? 447 ASN A CG  1 
ATOM   545  O OD1 . ASN A 1 68  ? 38.47910 -11.63164 -5.41368  1.000 33.19869 ? 447 ASN A OD1 1 
ATOM   546  N ND2 . ASN A 1 68  ? 37.42474 -9.68196  -5.06593  1.000 22.96670 ? 447 ASN A ND2 1 
ATOM   547  N N   . THR A 1 69  ? 36.15784 -9.12607  -9.97123  1.000 16.64770 ? 448 THR A N   1 
ATOM   548  C CA  . THR A 1 69  ? 36.14802 -8.52339  -11.30027 1.000 21.75980 ? 448 THR A CA  1 
ATOM   549  C C   . THR A 1 69  ? 35.52306 -7.13726  -11.18834 1.000 20.02344 ? 448 THR A C   1 
ATOM   550  O O   . THR A 1 69  ? 35.29590 -6.61087  -10.09248 1.000 16.75311 ? 448 THR A O   1 
ATOM   551  C CB  . THR A 1 69  ? 35.40392 -9.43016  -12.29334 1.000 18.94268 ? 448 THR A CB  1 
ATOM   552  O OG1 . THR A 1 69  ? 35.54548 -8.91050  -13.62075 1.000 20.15812 ? 448 THR A OG1 1 
ATOM   553  C CG2 . THR A 1 69  ? 33.91829 -9.51329  -11.93463 1.000 15.98328 ? 448 THR A CG2 1 
ATOM   554  N N   . MET A 1 70  ? 35.22496 -6.53189  -12.33208 1.000 18.75206 ? 449 MET A N   1 
ATOM   555  C CA  . MET A 1 70  ? 34.53965 -5.25162  -12.38391 1.000 22.85273 ? 449 MET A CA  1 
ATOM   556  C C   . MET A 1 70  ? 33.27197 -5.38853  -13.21082 1.000 19.48873 ? 449 MET A C   1 
ATOM   557  O O   . MET A 1 70  ? 33.21263 -6.17695  -14.15682 1.000 16.97481 ? 449 MET A O   1 
ATOM   558  C CB  . MET A 1 70  ? 35.43244 -4.16640  -12.98852 1.000 20.42488 ? 449 MET A CB  1 
ATOM   559  C CG  . MET A 1 70  ? 36.75923 -4.00837  -12.27414 1.000 28.74673 ? 449 MET A CG  1 
ATOM   560  S SD  . MET A 1 70  ? 36.62010 -3.09104  -10.73240 1.000 34.96730 ? 449 MET A SD  1 
ATOM   561  C CE  . MET A 1 70  ? 35.94641 -1.53872  -11.31629 1.000 22.18759 ? 449 MET A CE  1 
ATOM   562  N N   . ILE A 1 71  ? 32.25207 -4.62165  -12.83977 1.000 17.21474 ? 450 ILE A N   1 
ATOM   563  C CA  . ILE A 1 71  ? 31.02688 -4.51830  -13.62112 1.000 18.82789 ? 450 ILE A CA  1 
ATOM   564  C C   . ILE A 1 71  ? 30.88950 -3.07334  -14.08174 1.000 19.90941 ? 450 ILE A C   1 
ATOM   565  O O   . ILE A 1 71  ? 30.93232 -2.14163  -13.26685 1.000 17.37764 ? 450 ILE A O   1 
ATOM   566  C CB  . ILE A 1 71  ? 29.79004 -4.99266  -12.83612 1.000 15.40721 ? 450 ILE A CB  1 
ATOM   567  C CG1 . ILE A 1 71  ? 28.53013 -4.91650  -13.70711 1.000 19.77942 ? 450 ILE A CG1 1 
ATOM   568  C CG2 . ILE A 1 71  ? 29.62077 -4.22567  -11.51974 1.000 16.30652 ? 450 ILE A CG2 1 
ATOM   569  C CD1 . ILE A 1 71  ? 27.37161 -5.73388  -13.17311 1.000 20.74032 ? 450 ILE A CD1 1 
ATOM   570  N N   . LYS A 1 72  ? 30.78324 -2.88594  -15.39027 1.000 18.79875 ? 451 LYS A N   1 
ATOM   571  C CA  . LYS A 1 72  ? 30.64244 -1.56521  -15.98228 1.000 19.29627 ? 451 LYS A CA  1 
ATOM   572  C C   . LYS A 1 72  ? 29.19130 -1.35278  -16.39035 1.000 19.96969 ? 451 LYS A C   1 
ATOM   573  O O   . LYS A 1 72  ? 28.61470 -2.17822  -17.10710 1.000 17.90970 ? 451 LYS A O   1 
ATOM   574  C CB  . LYS A 1 72  ? 31.56832 -1.40649  -17.18979 1.000 17.45928 ? 451 LYS A CB  1 
ATOM   575  C CG  . LYS A 1 72  ? 31.41100 -0.08515  -17.92779 1.000 21.59421 ? 451 LYS A CG  1 
ATOM   576  C CD  . LYS A 1 72  ? 32.42259 0.02652   -19.05489 1.000 20.71197 ? 451 LYS A CD  1 
ATOM   577  C CE  . LYS A 1 72  ? 32.25083 1.31901   -19.83453 1.000 24.42385 ? 451 LYS A CE  1 
ATOM   578  N NZ  . LYS A 1 72  ? 32.43704 2.51840   -18.97232 1.000 22.06316 ? 451 LYS A NZ  1 
ATOM   579  N N   . GLY A 1 73  ? 28.60056 -0.25646  -15.92214 1.000 20.59783 ? 452 GLY A N   1 
ATOM   580  C CA  . GLY A 1 73  ? 27.23992 0.08332   -16.27646 1.000 21.39651 ? 452 GLY A CA  1 
ATOM   581  C C   . GLY A 1 73  ? 26.18751 -0.28439  -15.25510 1.000 23.57887 ? 452 GLY A C   1 
ATOM   582  O O   . GLY A 1 73  ? 25.00370 -0.00598  -15.48829 1.000 25.96338 ? 452 GLY A O   1 
ATOM   583  N N   . PHE A 1 74  ? 26.56918 -0.90537  -14.13674 1.000 20.90513 ? 453 PHE A N   1 
ATOM   584  C CA  . PHE A 1 74  ? 25.58754 -1.18658  -13.09524 1.000 16.89100 ? 453 PHE A CA  1 
ATOM   585  C C   . PHE A 1 74  ? 25.20024 0.08626   -12.35617 1.000 20.14483 ? 453 PHE A C   1 
ATOM   586  O O   . PHE A 1 74  ? 24.01681 0.33224   -12.10465 1.000 22.39659 ? 453 PHE A O   1 
ATOM   587  C CB  . PHE A 1 74  ? 26.12116 -2.23417  -12.11768 1.000 15.70764 ? 453 PHE A CB  1 
ATOM   588  C CG  . PHE A 1 74  ? 25.11370 -2.66283  -11.08515 1.000 17.74144 ? 453 PHE A CG  1 
ATOM   589  C CD1 . PHE A 1 74  ? 24.22800 -3.69494  -11.35006 1.000 20.96049 ? 453 PHE A CD1 1 
ATOM   590  C CD2 . PHE A 1 74  ? 25.04629 -2.02958  -9.85557  1.000 17.82903 ? 453 PHE A CD2 1 
ATOM   591  C CE1 . PHE A 1 74  ? 23.29702 -4.09019  -10.40683 1.000 22.32768 ? 453 PHE A CE1 1 
ATOM   592  C CE2 . PHE A 1 74  ? 24.11763 -2.41930  -8.90881  1.000 20.76870 ? 453 PHE A CE2 1 
ATOM   593  C CZ  . PHE A 1 74  ? 23.24067 -3.44786  -9.18554  1.000 18.15482 ? 453 PHE A CZ  1 
ATOM   594  N N   . ALA A 1 75  ? 26.18516 0.90688   -12.00242 1.000 18.25098 ? 454 ALA A N   1 
ATOM   595  C CA  . ALA A 1 75  ? 25.94538 2.15509   -11.28969 1.000 22.50995 ? 454 ALA A CA  1 
ATOM   596  C C   . ALA A 1 75  ? 27.23453 2.96112   -11.29436 1.000 25.14990 ? 454 ALA A C   1 
ATOM   597  O O   . ALA A 1 75  ? 28.29451 2.47577   -11.69936 1.000 20.40641 ? 454 ALA A O   1 
ATOM   598  C CB  . ALA A 1 75  ? 25.46968 1.91105   -9.85641  1.000 21.26207 ? 454 ALA A CB  1 
ATOM   599  N N   . SER A 1 76  ? 27.13057 4.20420   -10.82689 1.000 26.30882 ? 455 SER A N   1 
ATOM   600  C CA  . SER A 1 76  ? 28.28575 5.08121   -10.71984 1.000 24.70328 ? 455 SER A CA  1 
ATOM   601  C C   . SER A 1 76  ? 28.47149 5.69308   -9.33949  1.000 27.22163 ? 455 SER A C   1 
ATOM   602  O O   . SER A 1 76  ? 29.50076 6.33847   -9.11046  1.000 27.29614 ? 455 SER A O   1 
ATOM   603  C CB  . SER A 1 76  ? 28.20686 6.21042   -11.75969 1.000 27.05400 ? 455 SER A CB  1 
ATOM   604  O OG  . SER A 1 76  ? 26.92908 6.81715   -11.76236 1.000 34.65974 ? 455 SER A OG  1 
ATOM   605  N N   . SER A 1 77  ? 27.52139 5.51877   -8.41411  1.000 26.05323 ? 456 SER A N   1 
ATOM   606  C CA  . SER A 1 77  ? 27.73444 5.99776   -7.05344  1.000 23.34260 ? 456 SER A CA  1 
ATOM   607  C C   . SER A 1 77  ? 27.21109 5.02315   -6.00159  1.000 25.47721 ? 456 SER A C   1 
ATOM   608  O O   . SER A 1 77  ? 26.96164 5.43221   -4.86101  1.000 21.46485 ? 456 SER A O   1 
ATOM   609  C CB  . SER A 1 77  ? 27.10513 7.38363   -6.84487  1.000 23.63516 ? 456 SER A CB  1 
ATOM   610  O OG  . SER A 1 77  ? 25.79650 7.45731   -7.37418  1.000 27.44949 ? 456 SER A OG  1 
ATOM   611  N N   . VAL A 1 78  ? 27.04027 3.74891   -6.34813  1.000 22.66214 ? 457 VAL A N   1 
ATOM   612  C CA  . VAL A 1 78  ? 26.74573 2.73642   -5.34087  1.000 21.01366 ? 457 VAL A CA  1 
ATOM   613  C C   . VAL A 1 78  ? 28.02216 2.44600   -4.56344  1.000 21.73982 ? 457 VAL A C   1 
ATOM   614  O O   . VAL A 1 78  ? 29.04347 2.05243   -5.13973  1.000 19.98357 ? 457 VAL A O   1 
ATOM   615  C CB  . VAL A 1 78  ? 26.17723 1.46441   -5.98230  1.000 26.53299 ? 457 VAL A CB  1 
ATOM   616  C CG1 . VAL A 1 78  ? 26.27800 0.29037   -5.01589  1.000 16.59856 ? 457 VAL A CG1 1 
ATOM   617  C CG2 . VAL A 1 78  ? 24.73003 1.68450   -6.39909  1.000 20.38427 ? 457 VAL A CG2 1 
ATOM   618  N N   . GLN A 1 79  ? 27.97315 2.66236   -3.25027  1.000 23.53221 ? 458 GLN A N   1 
ATOM   619  C CA  . GLN A 1 79  ? 29.13855 2.49216   -2.39289  1.000 21.99494 ? 458 GLN A CA  1 
ATOM   620  C C   . GLN A 1 79  ? 29.30804 1.04314   -1.94377  1.000 24.67207 ? 458 GLN A C   1 
ATOM   621  O O   . GLN A 1 79  ? 30.37395 0.45001   -2.14427  1.000 19.83882 ? 458 GLN A O   1 
ATOM   622  C CB  . GLN A 1 79  ? 29.03525 3.43213   -1.18567  1.000 26.06757 ? 458 GLN A CB  1 
ATOM   623  C CG  . GLN A 1 79  ? 29.27733 4.90647   -1.51538  1.000 22.11023 ? 458 GLN A CG  1 
ATOM   624  C CD  . GLN A 1 79  ? 30.73039 5.20685   -1.82568  1.000 23.75799 ? 458 GLN A CD  1 
ATOM   625  O OE1 . GLN A 1 79  ? 31.23749 4.85061   -2.88855  1.000 26.67228 ? 458 GLN A OE1 1 
ATOM   626  N NE2 . GLN A 1 79  ? 31.40983 5.86616   -0.89333  1.000 25.86896 ? 458 GLN A NE2 1 
ATOM   627  N N   . GLY A 1 80  ? 28.27629 0.46356   -1.33128  1.000 24.16529 ? 459 GLY A N   1 
ATOM   628  C CA  . GLY A 1 80  ? 28.30996 -0.94775  -0.99430  1.000 21.84380 ? 459 GLY A CA  1 
ATOM   629  C C   . GLY A 1 80  ? 26.96291 -1.59885  -1.22685  1.000 25.48009 ? 459 GLY A C   1 
ATOM   630  O O   . GLY A 1 80  ? 25.94566 -1.06500  -0.78684  1.000 23.64084 ? 459 GLY A O   1 
ATOM   631  N N   . PHE A 1 81  ? 26.92130 -2.73488  -1.91980  1.000 24.32754 ? 460 PHE A N   1 
ATOM   632  C CA  . PHE A 1 81  ? 25.65639 -3.39496  -2.22197  1.000 22.50168 ? 460 PHE A CA  1 
ATOM   633  C C   . PHE A 1 81  ? 25.88054 -4.89637  -2.23791  1.000 26.14782 ? 460 PHE A C   1 
ATOM   634  O O   . PHE A 1 81  ? 26.62855 -5.40231  -3.07610  1.000 20.76788 ? 460 PHE A O   1 
ATOM   635  C CB  . PHE A 1 81  ? 25.09607 -2.91747  -3.56592  1.000 21.15249 ? 460 PHE A CB  1 
ATOM   636  C CG  . PHE A 1 81  ? 23.87451 -3.66546  -4.01205  1.000 23.96275 ? 460 PHE A CG  1 
ATOM   637  C CD1 . PHE A 1 81  ? 22.62655 -3.34430  -3.50709  1.000 21.47612 ? 460 PHE A CD1 1 
ATOM   638  C CD2 . PHE A 1 81  ? 23.97381 -4.69046  -4.93815  1.000 25.49384 ? 460 PHE A CD2 1 
ATOM   639  C CE1 . PHE A 1 81  ? 21.50381 -4.03198  -3.91761  1.000 24.06509 ? 460 PHE A CE1 1 
ATOM   640  C CE2 . PHE A 1 81  ? 22.85432 -5.38168  -5.34796  1.000 29.54064 ? 460 PHE A CE2 1 
ATOM   641  C CZ  . PHE A 1 81  ? 21.61828 -5.05269  -4.83699  1.000 21.99815 ? 460 PHE A CZ  1 
ATOM   642  N N   . VAL A 1 82  ? 25.22841 -5.61150  -1.32962  1.000 21.75816 ? 461 VAL A N   1 
ATOM   643  C CA  . VAL A 1 82  ? 25.41357 -7.05023  -1.20762  1.000 21.19496 ? 461 VAL A CA  1 
ATOM   644  C C   . VAL A 1 82  ? 24.05887 -7.73071  -1.33078  1.000 24.10503 ? 461 VAL A C   1 
ATOM   645  O O   . VAL A 1 82  ? 23.04731 -7.22079  -0.83904  1.000 21.78488 ? 461 VAL A O   1 
ATOM   646  C CB  . VAL A 1 82  ? 26.11509 -7.41901  0.11895   1.000 21.08992 ? 461 VAL A CB  1 
ATOM   647  C CG1 . VAL A 1 82  ? 26.18503 -8.92372  0.29862   1.000 20.48590 ? 461 VAL A CG1 1 
ATOM   648  C CG2 . VAL A 1 82  ? 27.52233 -6.82540  0.15555   1.000 22.06865 ? 461 VAL A CG2 1 
ATOM   649  N N   . SER A 1 83  ? 24.03695 -8.87106  -2.01260  1.000 20.33851 ? 462 SER A N   1 
ATOM   650  C CA  . SER A 1 83  ? 22.82072 -9.65475  -2.16432  1.000 16.35264 ? 462 SER A CA  1 
ATOM   651  C C   . SER A 1 83  ? 23.15615 -11.13219 -2.05458  1.000 16.70476 ? 462 SER A C   1 
ATOM   652  O O   . SER A 1 83  ? 24.04254 -11.62546 -2.75936  1.000 17.16425 ? 462 SER A O   1 
ATOM   653  C CB  . SER A 1 83  ? 22.13212 -9.36638  -3.50437  1.000 17.54576 ? 462 SER A CB  1 
ATOM   654  O OG  . SER A 1 83  ? 20.99015 -10.19103 -3.67462  1.000 20.00604 ? 462 SER A OG  1 
ATOM   655  N N   . SER A 1 84  ? 22.46121 -11.82566 -1.15515  1.000 16.58814 ? 463 SER A N   1 
ATOM   656  C CA  . SER A 1 84  ? 22.45942 -13.27978 -1.11759  1.000 19.52362 ? 463 SER A CA  1 
ATOM   657  C C   . SER A 1 84  ? 21.21572 -13.85381 -1.77430  1.000 22.11959 ? 463 SER A C   1 
ATOM   658  O O   . SER A 1 84  ? 20.99786 -15.06787 -1.71941  1.000 19.71591 ? 463 SER A O   1 
ATOM   659  C CB  . SER A 1 84  ? 22.56375 -13.78214 0.32250   1.000 18.41501 ? 463 SER A CB  1 
ATOM   660  O OG  . SER A 1 84  ? 21.31450 -13.70460 0.97946   1.000 20.66202 ? 463 SER A OG  1 
ATOM   661  N N   . PHE A 1 85  ? 20.38759 -13.00029 -2.37835  1.000 18.03174 ? 464 PHE A N   1 
ATOM   662  C CA  . PHE A 1 85  ? 19.15412 -13.42874 -3.03465  1.000 19.70736 ? 464 PHE A CA  1 
ATOM   663  C C   . PHE A 1 85  ? 19.49364 -13.89705 -4.44660  1.000 18.38525 ? 464 PHE A C   1 
ATOM   664  O O   . PHE A 1 85  ? 19.26993 -13.21063 -5.44642  1.000 17.53644 ? 464 PHE A O   1 
ATOM   665  C CB  . PHE A 1 85  ? 18.13085 -12.30141 -3.03485  1.000 21.06489 ? 464 PHE A CB  1 
ATOM   666  C CG  . PHE A 1 85  ? 16.80404 -12.68855 -3.61888  1.000 21.98547 ? 464 PHE A CG  1 
ATOM   667  C CD1 . PHE A 1 85  ? 16.04958 -13.69730 -3.04549  1.000 21.77292 ? 464 PHE A CD1 1 
ATOM   668  C CD2 . PHE A 1 85  ? 16.30360 -12.03464 -4.73241  1.000 21.29790 ? 464 PHE A CD2 1 
ATOM   669  C CE1 . PHE A 1 85  ? 14.82785 -14.05286 -3.57740  1.000 23.52820 ? 464 PHE A CE1 1 
ATOM   670  C CE2 . PHE A 1 85  ? 15.07829 -12.38617 -5.26911  1.000 28.13784 ? 464 PHE A CE2 1 
ATOM   671  C CZ  . PHE A 1 85  ? 14.34009 -13.39582 -4.68868  1.000 19.84883 ? 464 PHE A CZ  1 
ATOM   672  N N   . THR A 1 86  ? 20.05542 -15.09919 -4.51464  1.000 15.36596 ? 465 THR A N   1 
ATOM   673  C CA  . THR A 1 86  ? 20.42112 -15.73449 -5.76872  1.000 14.12620 ? 465 THR A CA  1 
ATOM   674  C C   . THR A 1 86  ? 19.87399 -17.15521 -5.77441  1.000 16.08643 ? 465 THR A C   1 
ATOM   675  O O   . THR A 1 86  ? 19.64121 -17.75429 -4.72138  1.000 15.42535 ? 465 THR A O   1 
ATOM   676  C CB  . THR A 1 86  ? 21.94621 -15.75477 -5.96824  1.000 17.89631 ? 465 THR A CB  1 
ATOM   677  O OG1 . THR A 1 86  ? 22.56385 -16.40197 -4.84766  1.000 14.56329 ? 465 THR A OG1 1 
ATOM   678  C CG2 . THR A 1 86  ? 22.50106 -14.33299 -6.09708  1.000 14.37572 ? 465 THR A CG2 1 
ATOM   679  N N   . THR A 1 87  ? 19.66467 -17.69518 -6.97769  1.000 14.64458 ? 466 THR A N   1 
ATOM   680  C CA  . THR A 1 87  ? 19.22465 -19.08111 -7.08761  1.000 14.39333 ? 466 THR A CA  1 
ATOM   681  C C   . THR A 1 87  ? 20.32555 -20.05765 -6.69797  1.000 18.32247 ? 466 THR A C   1 
ATOM   682  O O   . THR A 1 87  ? 20.02423 -21.18540 -6.29329  1.000 17.32356 ? 466 THR A O   1 
ATOM   683  C CB  . THR A 1 87  ? 18.73657 -19.37645 -8.50891  1.000 16.73322 ? 466 THR A CB  1 
ATOM   684  O OG1 . THR A 1 87  ? 19.80948 -19.18126 -9.43819  1.000 16.01090 ? 466 THR A OG1 1 
ATOM   685  C CG2 . THR A 1 87  ? 17.58022 -18.45413 -8.87857  1.000 15.08193 ? 466 THR A CG2 1 
ATOM   686  N N   . THR A 1 88  ? 21.59066 -19.64907 -6.80627  1.000 18.70388 ? 467 THR A N   1 
ATOM   687  C CA  . THR A 1 88  ? 22.69332 -20.49493 -6.37386  1.000 18.90336 ? 467 THR A CA  1 
ATOM   688  C C   . THR A 1 88  ? 22.95042 -20.39887 -4.87682  1.000 22.28658 ? 467 THR A C   1 
ATOM   689  O O   . THR A 1 88  ? 23.57894 -21.29982 -4.31231  1.000 19.01878 ? 467 THR A O   1 
ATOM   690  C CB  . THR A 1 88  ? 23.97517 -20.12308 -7.12478  1.000 21.99409 ? 467 THR A CB  1 
ATOM   691  O OG1 . THR A 1 88  ? 24.26173 -18.73488 -6.91448  1.000 17.17299 ? 467 THR A OG1 1 
ATOM   692  C CG2 . THR A 1 88  ? 23.83005 -20.39088 -8.62592  1.000 19.22897 ? 467 THR A CG2 1 
ATOM   693  N N   . GLY A 1 89  ? 22.48147 -19.33699 -4.22413  1.000 15.94104 ? 468 GLY A N   1 
ATOM   694  C CA  . GLY A 1 89  ? 22.87095 -19.05552 -2.86053  1.000 20.25715 ? 468 GLY A CA  1 
ATOM   695  C C   . GLY A 1 89  ? 24.19277 -18.33621 -2.71706  1.000 18.81791 ? 468 GLY A C   1 
ATOM   696  O O   . GLY A 1 89  ? 24.56266 -17.97713 -1.59171  1.000 17.60976 ? 468 GLY A O   1 
ATOM   697  N N   . ASP A 1 90  ? 24.91989 -18.12546 -3.81230  1.000 13.61312 ? 469 ASP A N   1 
ATOM   698  C CA  . ASP A 1 90  ? 26.17703 -17.39765 -3.75786  1.000 18.97687 ? 469 ASP A CA  1 
ATOM   699  C C   . ASP A 1 90  ? 25.92210 -15.91054 -3.51603  1.000 18.36597 ? 469 ASP A C   1 
ATOM   700  O O   . ASP A 1 90  ? 24.82747 -15.39036 -3.75084  1.000 18.00000 ? 469 ASP A O   1 
ATOM   701  C CB  . ASP A 1 90  ? 26.97008 -17.60417 -5.04889  1.000 17.28356 ? 469 ASP A CB  1 
ATOM   702  C CG  . ASP A 1 90  ? 27.35529 -19.05609 -5.26737  1.000 23.15012 ? 469 ASP A CG  1 
ATOM   703  O OD1 . ASP A 1 90  ? 27.55904 -19.76955 -4.26232  1.000 18.88140 ? 469 ASP A OD1 1 
ATOM   704  O OD2 . ASP A 1 90  ? 27.44593 -19.48790 -6.43655  1.000 21.81729 ? 469 ASP A OD2 1 
ATOM   705  N N   . ILE A 1 91  ? 26.95876 -15.22403 -3.04300  1.000 16.86136 ? 470 ILE A N   1 
ATOM   706  C CA  . ILE A 1 91  ? 26.85191 -13.84645 -2.57474  1.000 18.23818 ? 470 ILE A CA  1 
ATOM   707  C C   . ILE A 1 91  ? 27.42149 -12.91809 -3.63743  1.000 20.09533 ? 470 ILE A C   1 
ATOM   708  O O   . ILE A 1 91  ? 28.49713 -13.18210 -4.18650  1.000 17.61678 ? 470 ILE A O   1 
ATOM   709  C CB  . ILE A 1 91  ? 27.59174 -13.66418 -1.23838  1.000 18.93089 ? 470 ILE A CB  1 
ATOM   710  C CG1 . ILE A 1 91  ? 27.32065 -14.85145 -0.30780  1.000 23.01827 ? 470 ILE A CG1 1 
ATOM   711  C CG2 . ILE A 1 91  ? 27.19670 -12.35277 -0.58560  1.000 17.58880 ? 470 ILE A CG2 1 
ATOM   712  C CD1 . ILE A 1 91  ? 25.91662 -14.90316 0.24552   1.000 23.99282 ? 470 ILE A CD1 1 
ATOM   713  N N   . VAL A 1 92  ? 26.71586 -11.82527 -3.92316  1.000 14.26300 ? 471 VAL A N   1 
ATOM   714  C CA  . VAL A 1 92  ? 27.19448 -10.79390 -4.83819  1.000 21.20512 ? 471 VAL A CA  1 
ATOM   715  C C   . VAL A 1 92  ? 27.46930 -9.53502  -4.03107  1.000 17.41708 ? 471 VAL A C   1 
ATOM   716  O O   . VAL A 1 92  ? 26.64962 -9.13811  -3.19613  1.000 17.84286 ? 471 VAL A O   1 
ATOM   717  C CB  . VAL A 1 92  ? 26.18272 -10.50974 -5.96268  1.000 22.64548 ? 471 VAL A CB  1 
ATOM   718  C CG1 . VAL A 1 92  ? 26.70154 -9.40044  -6.88177  1.000 20.21112 ? 471 VAL A CG1 1 
ATOM   719  C CG2 . VAL A 1 92  ? 25.89773 -11.77708 -6.75104  1.000 25.74264 ? 471 VAL A CG2 1 
ATOM   720  N N   . ALA A 1 93  ? 28.61780 -8.90985  -4.27708  1.000 15.45688 ? 472 ALA A N   1 
ATOM   721  C CA  . ALA A 1 93  ? 28.95750 -7.62511  -3.68393  1.000 18.99937 ? 472 ALA A CA  1 
ATOM   722  C C   . ALA A 1 93  ? 29.42456 -6.69328  -4.79071  1.000 20.74815 ? 472 ALA A C   1 
ATOM   723  O O   . ALA A 1 93  ? 30.33394 -7.03307  -5.54899  1.000 14.80323 ? 472 ALA A O   1 
ATOM   724  C CB  . ALA A 1 93  ? 30.03982 -7.77347  -2.60915  1.000 18.91242 ? 472 ALA A CB  1 
ATOM   725  N N   . ILE A 1 94  ? 28.79986 -5.52580  -4.88051  1.000 20.32203 ? 473 ILE A N   1 
ATOM   726  C CA  . ILE A 1 94  ? 29.07866 -4.54088  -5.91592  1.000 14.75393 ? 473 ILE A CA  1 
ATOM   727  C C   . ILE A 1 94  ? 29.25966 -3.18812  -5.24452  1.000 20.26332 ? 473 ILE A C   1 
ATOM   728  O O   . ILE A 1 94  ? 28.52531 -2.84542  -4.31344  1.000 15.76004 ? 473 ILE A O   1 
ATOM   729  C CB  . ILE A 1 94  ? 27.93844 -4.48089  -6.95759  1.000 15.76282 ? 473 ILE A CB  1 
ATOM   730  C CG1 . ILE A 1 94  ? 27.83581 -5.79341  -7.73795  1.000 15.18125 ? 473 ILE A CG1 1 
ATOM   731  C CG2 . ILE A 1 94  ? 28.11471 -3.30026  -7.89911  1.000 15.65599 ? 473 ILE A CG2 1 
ATOM   732  C CD1 . ILE A 1 94  ? 26.59713 -5.88160  -8.60581  1.000 13.85871 ? 473 ILE A CD1 1 
ATOM   733  N N   . GLY A 1 95  ? 30.23183 -2.41694  -5.70887  1.000 18.15509 ? 474 GLY A N   1 
ATOM   734  C CA  . GLY A 1 95  ? 30.32383 -1.06022  -5.20383  1.000 20.07911 ? 474 GLY A CA  1 
ATOM   735  C C   . GLY A 1 95  ? 31.64694 -0.39724  -5.51073  1.000 22.08518 ? 474 GLY A C   1 
ATOM   736  O O   . GLY A 1 95  ? 32.51715 -0.95302  -6.18142  1.000 20.86291 ? 474 GLY A O   1 
ATOM   737  N N   . LYS A 1 96  ? 31.77421 0.82678   -4.99887  1.000 24.15904 ? 475 LYS A N   1 
ATOM   738  C CA  . LYS A 1 96  ? 32.95960 1.64094   -5.21252  1.000 23.93890 ? 475 LYS A CA  1 
ATOM   739  C C   . LYS A 1 96  ? 33.72422 1.94431   -3.93215  1.000 25.30085 ? 475 LYS A C   1 
ATOM   740  O O   . LYS A 1 96  ? 34.77659 2.58829   -3.99826  1.000 25.03447 ? 475 LYS A O   1 
ATOM   741  C CB  . LYS A 1 96  ? 32.57525 2.95753   -5.90280  1.000 22.97679 ? 475 LYS A CB  1 
ATOM   742  C CG  . LYS A 1 96  ? 31.99381 2.77168   -7.29379  1.000 25.84906 ? 475 LYS A CG  1 
ATOM   743  C CD  . LYS A 1 96  ? 31.97131 4.08259   -8.05776  1.000 26.06181 ? 475 LYS A CD  1 
ATOM   744  C CE  . LYS A 1 96  ? 31.76338 3.84715   -9.54849  1.000 24.63395 ? 475 LYS A CE  1 
ATOM   745  N NZ  . LYS A 1 96  ? 32.10233 5.04671   -10.36059 1.000 27.30628 ? 475 LYS A NZ  1 
ATOM   746  N N   . ASN A 1 97  ? 33.22692 1.50506   -2.77781  1.000 21.26049 ? 476 ASN A N   1 
ATOM   747  C CA  . ASN A 1 97  ? 33.91597 1.65961   -1.50221  1.000 26.04616 ? 476 ASN A CA  1 
ATOM   748  C C   . ASN A 1 97  ? 33.97011 0.29686   -0.82961  1.000 23.71277 ? 476 ASN A C   1 
ATOM   749  O O   . ASN A 1 97  ? 32.92570 -0.27957  -0.50682  1.000 23.87999 ? 476 ASN A O   1 
ATOM   750  C CB  . ASN A 1 97  ? 33.20816 2.68539   -0.61004  1.000 23.77214 ? 476 ASN A CB  1 
ATOM   751  C CG  . ASN A 1 97  ? 33.92859 2.91579   0.70771   1.000 27.80202 ? 476 ASN A CG  1 
ATOM   752  O OD1 . ASN A 1 97  ? 33.72650 2.18159   1.67302   1.000 31.31928 ? 476 ASN A OD1 1 
ATOM   753  N ND2 . ASN A 1 97  ? 34.76371 3.94546   0.75572   1.000 30.49664 ? 476 ASN A ND2 1 
ATOM   754  N N   . LYS A 1 98  ? 35.18740 -0.21496  -0.62657  1.000 21.52143 ? 477 LYS A N   1 
ATOM   755  C CA  . LYS A 1 98  ? 35.35385 -1.55948  -0.08242  1.000 25.13767 ? 477 LYS A CA  1 
ATOM   756  C C   . LYS A 1 98  ? 34.83601 -1.65393  1.34740   1.000 24.64450 ? 477 LYS A C   1 
ATOM   757  O O   . LYS A 1 98  ? 34.31181 -2.69794  1.75739   1.000 20.94214 ? 477 LYS A O   1 
ATOM   758  C CB  . LYS A 1 98  ? 36.82494 -1.96473  -0.14340  1.000 29.36189 ? 477 LYS A CB  1 
ATOM   759  C CG  . LYS A 1 98  ? 37.42328 -1.94714  -1.54093  1.000 25.63454 ? 477 LYS A CG  1 
ATOM   760  C CD  . LYS A 1 98  ? 38.87274 -2.40250  -1.50240  1.000 24.73760 ? 477 LYS A CD  1 
ATOM   761  C CE  . LYS A 1 98  ? 39.45540 -2.60928  -2.90212  1.000 23.93347 ? 477 LYS A CE  1 
ATOM   762  N NZ  . LYS A 1 98  ? 40.83644 -3.18146  -2.84094  1.000 19.54326 ? 477 LYS A NZ  1 
ATOM   763  N N   . ALA A 1 99  ? 34.98780 -0.57961  2.12482   1.000 26.90645 ? 478 ALA A N   1 
ATOM   764  C CA  . ALA A 1 99  ? 34.49261 -0.58057  3.49682   1.000 27.26570 ? 478 ALA A CA  1 
ATOM   765  C C   . ALA A 1 99  ? 32.97568 -0.71689  3.52677   1.000 23.95215 ? 478 ALA A C   1 
ATOM   766  O O   . ALA A 1 99  ? 32.42495 -1.48637  4.32277   1.000 25.59413 ? 478 ALA A O   1 
ATOM   767  C CB  . ALA A 1 99  ? 34.94160 0.69175   4.21775   1.000 26.55712 ? 478 ALA A CB  1 
ATOM   768  N N   . ASP A 1 100 ? 32.28132 0.01661   2.65236   1.000 20.35236 ? 479 ASP A N   1 
ATOM   769  C CA  . ASP A 1 100 ? 30.82890 -0.10002  2.58446   1.000 23.17773 ? 479 ASP A CA  1 
ATOM   770  C C   . ASP A 1 100 ? 30.39470 -1.46564  2.06704   1.000 20.05271 ? 479 ASP A C   1 
ATOM   771  O O   . ASP A 1 100 ? 29.35549 -1.97841  2.49023   1.000 21.27919 ? 479 ASP A O   1 
ATOM   772  C CB  . ASP A 1 100 ? 30.25121 1.01447   1.71384   1.000 22.12066 ? 479 ASP A CB  1 
ATOM   773  C CG  . ASP A 1 100 ? 30.24036 2.35753   2.42217   1.000 28.70297 ? 479 ASP A CG  1 
ATOM   774  O OD1 . ASP A 1 100 ? 30.10597 2.37158   3.66414   1.000 29.91326 ? 479 ASP A OD1 1 
ATOM   775  O OD2 . ASP A 1 100 ? 30.36449 3.39626   1.74095   1.000 24.80807 ? 479 ASP A OD2 1 
ATOM   776  N N   . MET A 1 101 ? 31.17480 -2.07613  1.17026   1.000 19.54784 ? 480 MET A N   1 
ATOM   777  C CA  . MET A 1 101 ? 30.86032 -3.43079  0.72116   1.000 23.37904 ? 480 MET A CA  1 
ATOM   778  C C   . MET A 1 101 ? 30.97646 -4.42981  1.86721   1.000 22.15612 ? 480 MET A C   1 
ATOM   779  O O   . MET A 1 101 ? 30.09236 -5.27662  2.05553   1.000 19.44020 ? 480 MET A O   1 
ATOM   780  C CB  . MET A 1 101 ? 31.77395 -3.82833  -0.44248  1.000 18.03519 ? 480 MET A CB  1 
ATOM   781  C CG  . MET A 1 101 ? 31.54056 -3.01677  -1.71772  1.000 19.26167 ? 480 MET A CG  1 
ATOM   782  S SD  . MET A 1 101 ? 32.81081 -3.22460  -2.98903  1.000 22.60490 ? 480 MET A SD  1 
ATOM   783  C CE  . MET A 1 101 ? 32.44196 -4.87237  -3.58615  1.000 23.42375 ? 480 MET A CE  1 
ATOM   784  N N   . LEU A 1 102 ? 32.05881 -4.34117  2.64829   1.000 27.63259 ? 481 LEU A N   1 
ATOM   785  C CA  . LEU A 1 102 ? 32.20378 -5.20177  3.81976   1.000 26.20991 ? 481 LEU A CA  1 
ATOM   786  C C   . LEU A 1 102 ? 31.06901 -4.98073  4.81190   1.000 23.46011 ? 481 LEU A C   1 
ATOM   787  O O   . LEU A 1 102 ? 30.53856 -5.94088  5.38889   1.000 24.23702 ? 481 LEU A O   1 
ATOM   788  C CB  . LEU A 1 102 ? 33.55337 -4.94928  4.49215   1.000 24.53204 ? 481 LEU A CB  1 
ATOM   789  C CG  . LEU A 1 102 ? 34.80429 -5.31970  3.69517   1.000 27.76469 ? 481 LEU A CG  1 
ATOM   790  C CD1 . LEU A 1 102 ? 36.06406 -5.01342  4.49910   1.000 29.50847 ? 481 LEU A CD1 1 
ATOM   791  C CD2 . LEU A 1 102 ? 34.76454 -6.78727  3.28454   1.000 26.93483 ? 481 LEU A CD2 1 
ATOM   792  N N   . LEU A 1 103 ? 30.69143 -3.71835  5.02926   1.000 20.88997 ? 482 LEU A N   1 
ATOM   793  C CA  . LEU A 1 103 ? 29.60415 -3.40896  5.95158   1.000 27.43701 ? 482 LEU A CA  1 
ATOM   794  C C   . LEU A 1 103 ? 28.28675 -4.00224  5.46616   1.000 28.20027 ? 482 LEU A C   1 
ATOM   795  O O   . LEU A 1 103 ? 27.51401 -4.56231  6.25401   1.000 27.82856 ? 482 LEU A O   1 
ATOM   796  C CB  . LEU A 1 103 ? 29.48957 -1.89382  6.12040   1.000 25.86270 ? 482 LEU A CB  1 
ATOM   797  C CG  . LEU A 1 103 ? 28.21194 -1.35520  6.76360   1.000 28.92985 ? 482 LEU A CG  1 
ATOM   798  C CD1 . LEU A 1 103 ? 28.08394 -1.82565  8.20634   1.000 30.59410 ? 482 LEU A CD1 1 
ATOM   799  C CD2 . LEU A 1 103 ? 28.18199 0.16397   6.68366   1.000 25.98266 ? 482 LEU A CD2 1 
ATOM   800  N N   . ALA A 1 104 ? 28.01374 -3.88636  4.16452   1.000 25.54309 ? 483 ALA A N   1 
ATOM   801  C CA  . ALA A 1 104 ? 26.78104 -4.43537  3.61665   1.000 22.96478 ? 483 ALA A CA  1 
ATOM   802  C C   . ALA A 1 104 ? 26.76282 -5.95157  3.72708   1.000 22.63221 ? 483 ALA A C   1 
ATOM   803  O O   . ALA A 1 104 ? 25.71520 -6.54430  3.99441   1.000 22.69063 ? 483 ALA A O   1 
ATOM   804  C CB  . ALA A 1 104 ? 26.60794 -3.99334  2.16507   1.000 22.69675 ? 483 ALA A CB  1 
ATOM   805  N N   . PHE A 1 105 ? 27.91768 -6.59568  3.54871   1.000 20.39118 ? 484 PHE A N   1 
ATOM   806  C CA  . PHE A 1 105 ? 27.98411 -8.04517  3.71945   1.000 23.75257 ? 484 PHE A CA  1 
ATOM   807  C C   . PHE A 1 105 ? 27.69127 -8.44517  5.16296   1.000 26.52686 ? 484 PHE A C   1 
ATOM   808  O O   . PHE A 1 105 ? 26.89741 -9.36406  5.41896   1.000 25.67512 ? 484 PHE A O   1 
ATOM   809  C CB  . PHE A 1 105 ? 29.35788 -8.55610  3.28539   1.000 19.70463 ? 484 PHE A CB  1 
ATOM   810  C CG  . PHE A 1 105 ? 29.50966 -10.04952 3.37167   1.000 25.97500 ? 484 PHE A CG  1 
ATOM   811  C CD1 . PHE A 1 105 ? 29.87447 -10.65826 4.56280   1.000 29.31015 ? 484 PHE A CD1 1 
ATOM   812  C CD2 . PHE A 1 105 ? 29.30065 -10.84445 2.25726   1.000 21.80546 ? 484 PHE A CD2 1 
ATOM   813  C CE1 . PHE A 1 105 ? 30.02340 -12.02724 4.63799   1.000 27.54579 ? 484 PHE A CE1 1 
ATOM   814  C CE2 . PHE A 1 105 ? 29.44727 -12.21391 2.32984   1.000 18.74184 ? 484 PHE A CE2 1 
ATOM   815  C CZ  . PHE A 1 105 ? 29.80776 -12.80572 3.52174   1.000 27.37632 ? 484 PHE A CZ  1 
ATOM   816  N N   . ALA A 1 106 ? 28.34731 -7.78239  6.12118   1.000 24.77408 ? 485 ALA A N   1 
ATOM   817  C CA  . ALA A 1 106 ? 28.11496 -8.09711  7.52798   1.000 26.68891 ? 485 ALA A CA  1 
ATOM   818  C C   . ALA A 1 106 ? 26.65294 -7.89183  7.90214   1.000 26.06520 ? 485 ALA A C   1 
ATOM   819  O O   . ALA A 1 106 ? 26.05428 -8.73001  8.59017   1.000 27.73209 ? 485 ALA A O   1 
ATOM   820  C CB  . ALA A 1 106 ? 29.02138 -7.24465  8.41535   1.000 24.89036 ? 485 ALA A CB  1 
ATOM   821  N N   . ARG A 1 107 ? 26.05831 -6.78573  7.44457   1.000 22.62506 ? 486 ARG A N   1 
ATOM   822  C CA  . ARG A 1 107 ? 24.65241 -6.52286  7.73081   1.000 24.47130 ? 486 ARG A CA  1 
ATOM   823  C C   . ARG A 1 107 ? 23.74722 -7.55428  7.06537   1.000 27.94893 ? 486 ARG A C   1 
ATOM   824  O O   . ARG A 1 107 ? 22.73574 -7.96666  7.64575   1.000 28.32619 ? 486 ARG A O   1 
ATOM   825  C CB  . ARG A 1 107 ? 24.28715 -5.11269  7.27374   1.000 23.70783 ? 486 ARG A CB  1 
ATOM   826  C CG  . ARG A 1 107 ? 22.86189 -4.71234  7.59651   1.000 28.22503 ? 486 ARG A CG  1 
ATOM   827  C CD  . ARG A 1 107 ? 22.57575 -4.88001  9.07971   1.000 29.69154 ? 486 ARG A CD  1 
ATOM   828  N NE  . ARG A 1 107 ? 21.19636 -4.54192  9.40575   1.000 31.75818 ? 486 ARG A NE  1 
ATOM   829  C CZ  . ARG A 1 107 ? 20.60630 -4.82990  10.55774  1.000 33.77136 ? 486 ARG A CZ  1 
ATOM   830  N NH1 . ARG A 1 107 ? 21.24776 -5.47106  11.52237  1.000 34.58882 ? 486 ARG A NH1 1 
ATOM   831  N NH2 . ARG A 1 107 ? 19.33970 -4.47091  10.74529  1.000 36.59344 ? 486 ARG A NH2 1 
ATOM   832  N N   . MET A 1 108 ? 24.08884 -7.97528  5.84397   1.000 25.97636 ? 487 MET A N   1 
ATOM   833  C CA  . MET A 1 108 ? 23.33215 -9.02268  5.16663   1.000 22.02900 ? 487 MET A CA  1 
ATOM   834  C C   . MET A 1 108 ? 23.31535 -10.29551 5.99758   1.000 22.47504 ? 487 MET A C   1 
ATOM   835  O O   . MET A 1 108 ? 22.27766 -10.95370 6.13370   1.000 24.55427 ? 487 MET A O   1 
ATOM   836  C CB  . MET A 1 108 ? 23.93496 -9.28077  3.78183   1.000 21.21650 ? 487 MET A CB  1 
ATOM   837  C CG  . MET A 1 108 ? 23.26470 -10.38270 2.97347   1.000 20.87433 ? 487 MET A CG  1 
ATOM   838  S SD  . MET A 1 108 ? 23.88225 -12.03725 3.35387   1.000 20.76628 ? 487 MET A SD  1 
ATOM   839  C CE  . MET A 1 108 ? 25.64254 -11.82025 3.08911   1.000 23.90989 ? 487 MET A CE  1 
ATOM   840  N N   . LYS A 1 109 ? 24.46705 -10.65758 6.56156   1.000 23.73291 ? 488 LYS A N   1 
ATOM   841  C CA  . LYS A 1 109 ? 24.50914 -11.82829 7.43213   1.000 28.08952 ? 488 LYS A CA  1 
ATOM   842  C C   . LYS A 1 109 ? 23.67955 -11.61236 8.69275   1.000 31.77509 ? 488 LYS A C   1 
ATOM   843  O O   . LYS A 1 109 ? 22.96513 -12.52018 9.13391   1.000 29.26817 ? 488 LYS A O   1 
ATOM   844  C CB  . LYS A 1 109 ? 25.95249 -12.17094 7.78970   1.000 30.41894 ? 488 LYS A CB  1 
ATOM   845  C CG  . LYS A 1 109 ? 26.57479 -13.19047 6.86174   1.000 31.27037 ? 488 LYS A CG  1 
ATOM   846  C CD  . LYS A 1 109 ? 28.06448 -13.30192 7.09512   1.000 34.98528 ? 488 LYS A CD  1 
ATOM   847  C CE  . LYS A 1 109 ? 28.39322 -13.51647 8.55986   1.000 41.34507 ? 488 LYS A CE  1 
ATOM   848  N NZ  . LYS A 1 109 ? 29.85434 -13.74574 8.75518   1.000 40.62527 ? 488 LYS A NZ  1 
ATOM   849  N N   . GLU A 1 110 ? 23.75489 -10.41368 9.28142   1.000 31.72188 ? 489 GLU A N   1 
ATOM   850  C CA  . GLU A 1 110 ? 23.02233 -10.14376 10.51833  1.000 36.88475 ? 489 GLU A CA  1 
ATOM   851  C C   . GLU A 1 110 ? 21.52175 -10.34894 10.34507  1.000 31.90892 ? 489 GLU A C   1 
ATOM   852  O O   . GLU A 1 110 ? 20.86335 -10.92781 11.21740  1.000 35.48911 ? 489 GLU A O   1 
ATOM   853  C CB  . GLU A 1 110 ? 23.30208 -8.72139  10.99908  1.000 32.32251 ? 489 GLU A CB  1 
ATOM   854  C CG  . GLU A 1 110 ? 24.65062 -8.53387  11.65520  1.000 34.52572 ? 489 GLU A CG  1 
ATOM   855  C CD  . GLU A 1 110 ? 24.89143 -7.09218  12.06498  1.000 40.90579 ? 489 GLU A CD  1 
ATOM   856  O OE1 . GLU A 1 110 ? 23.92070 -6.30254  12.07296  1.000 36.99118 ? 489 GLU A OE1 1 
ATOM   857  O OE2 . GLU A 1 110 ? 26.05309 -6.74741  12.37029  1.000 43.46419 ? 489 GLU A OE2 1 
ATOM   858  N N   . ILE A 1 111 ? 20.95806 -9.87997  9.22671   1.000 28.06713 ? 490 ILE A N   1 
ATOM   859  C CA  . ILE A 1 111 ? 19.51356 -9.97517  9.02128   1.000 23.33920 ? 490 ILE A CA  1 
ATOM   860  C C   . ILE A 1 111 ? 19.08481 -11.31986 8.46141   1.000 25.54527 ? 490 ILE A C   1 
ATOM   861  O O   . ILE A 1 111 ? 17.90333 -11.49226 8.13497   1.000 27.36980 ? 490 ILE A O   1 
ATOM   862  C CB  . ILE A 1 111 ? 19.01517 -8.84160  8.10159   1.000 27.61297 ? 490 ILE A CB  1 
ATOM   863  C CG1 . ILE A 1 111 ? 19.45212 -9.07601  6.65530   1.000 25.09928 ? 490 ILE A CG1 1 
ATOM   864  C CG2 . ILE A 1 111 ? 19.54120 -7.50700  8.59010   1.000 27.21721 ? 490 ILE A CG2 1 
ATOM   865  C CD1 . ILE A 1 111 ? 19.05970 -7.95302  5.71213   1.000 24.40580 ? 490 ILE A CD1 1 
ATOM   866  N N   . GLY A 1 112 ? 20.00045 -12.27891 8.34363   1.000 29.61347 ? 491 GLY A N   1 
ATOM   867  C CA  . GLY A 1 112 ? 19.64600 -13.60816 7.88979   1.000 28.15560 ? 491 GLY A CA  1 
ATOM   868  C C   . GLY A 1 112 ? 19.59196 -13.79025 6.39125   1.000 31.30517 ? 491 GLY A C   1 
ATOM   869  O O   . GLY A 1 112 ? 18.79896 -14.60512 5.90438   1.000 27.45021 ? 491 GLY A O   1 
ATOM   870  N N   . GLY A 1 113 ? 20.41454 -13.06877 5.64120   1.000 31.17329 ? 492 GLY A N   1 
ATOM   871  C CA  . GLY A 1 113 ? 20.38114 -13.13337 4.19687   1.000 24.68606 ? 492 GLY A CA  1 
ATOM   872  C C   . GLY A 1 113 ? 19.44188 -12.10230 3.59451   1.000 21.65534 ? 492 GLY A C   1 
ATOM   873  O O   . GLY A 1 113 ? 18.53806 -11.57884 4.24456   1.000 24.90462 ? 492 GLY A O   1 
ATOM   874  N N   . GLY A 1 114 ? 19.67118 -11.81144 2.31716   1.000 19.40363 ? 493 GLY A N   1 
ATOM   875  C CA  . GLY A 1 114 ? 18.87160 -10.82493 1.62122   1.000 17.71709 ? 493 GLY A CA  1 
ATOM   876  C C   . GLY A 1 114 ? 19.70145 -9.81020  0.86538   1.000 20.81725 ? 493 GLY A C   1 
ATOM   877  O O   . GLY A 1 114 ? 20.75137 -10.14337 0.30817   1.000 21.83555 ? 493 GLY A O   1 
ATOM   878  N N   . ILE A 1 115 ? 19.24332 -8.56190  0.85204   1.000 17.91677 ? 494 ILE A N   1 
ATOM   879  C CA  . ILE A 1 115 ? 19.84899 -7.50103  0.05613   1.000 19.71771 ? 494 ILE A CA  1 
ATOM   880  C C   . ILE A 1 115 ? 20.10539 -6.30437  0.96170   1.000 23.34500 ? 494 ILE A C   1 
ATOM   881  O O   . ILE A 1 115 ? 19.22043 -5.89686  1.71627   1.000 21.90174 ? 494 ILE A O   1 
ATOM   882  C CB  . ILE A 1 115 ? 18.94267 -7.10750  -1.12595  1.000 18.08104 ? 494 ILE A CB  1 
ATOM   883  C CG1 . ILE A 1 115 ? 18.72295 -8.30972  -2.04893  1.000 20.30687 ? 494 ILE A CG1 1 
ATOM   884  C CG2 . ILE A 1 115 ? 19.53015 -5.93820  -1.88947  1.000 19.56409 ? 494 ILE A CG2 1 
ATOM   885  C CD1 . ILE A 1 115 ? 17.67651 -8.07883  -3.11743  1.000 20.29731 ? 494 ILE A CD1 1 
ATOM   886  N N   . VAL A 1 116 ? 21.31155 -5.74524  0.89679   1.000 20.95602 ? 495 VAL A N   1 
ATOM   887  C CA  . VAL A 1 116 ? 21.68484 -4.60468  1.72917   1.000 22.05973 ? 495 VAL A CA  1 
ATOM   888  C C   . VAL A 1 116 ? 22.44776 -3.59990  0.87944   1.000 22.45619 ? 495 VAL A C   1 
ATOM   889  O O   . VAL A 1 116 ? 23.46401 -3.94065  0.26472   1.000 22.38619 ? 495 VAL A O   1 
ATOM   890  C CB  . VAL A 1 116 ? 22.53341 -5.02013  2.94865   1.000 24.44310 ? 495 VAL A CB  1 
ATOM   891  C CG1 . VAL A 1 116 ? 23.00024 -3.79304  3.71129   1.000 22.48122 ? 495 VAL A CG1 1 
ATOM   892  C CG2 . VAL A 1 116 ? 21.74065 -5.95027  3.86731   1.000 21.09142 ? 495 VAL A CG2 1 
ATOM   893  N N   . LEU A 1 117 ? 21.96015 -2.36268  0.85740   1.000 20.84404 ? 496 LEU A N   1 
ATOM   894  C CA  . LEU A 1 117 ? 22.63578 -1.22481  0.25229   1.000 20.44431 ? 496 LEU A CA  1 
ATOM   895  C C   . LEU A 1 117 ? 23.14157 -0.32548  1.37374   1.000 26.97490 ? 496 LEU A C   1 
ATOM   896  O O   . LEU A 1 117 ? 22.34042 0.20359   2.15654   1.000 25.76374 ? 496 LEU A O   1 
ATOM   897  C CB  . LEU A 1 117 ? 21.68469 -0.46370  -0.67020  1.000 18.33815 ? 496 LEU A CB  1 
ATOM   898  C CG  . LEU A 1 117 ? 22.21241 0.80093   -1.34508  1.000 28.25610 ? 496 LEU A CG  1 
ATOM   899  C CD1 . LEU A 1 117 ? 23.33866 0.47209   -2.31209  1.000 23.64463 ? 496 LEU A CD1 1 
ATOM   900  C CD2 . LEU A 1 117 ? 21.08392 1.53078   -2.05602  1.000 23.45128 ? 496 LEU A CD2 1 
ATOM   901  N N   . ALA A 1 118 ? 24.46427 -0.17496  1.45316   1.000 21.20616 ? 497 ALA A N   1 
ATOM   902  C CA  . ALA A 1 118 ? 25.15881 0.60923   2.45995   1.000 24.19301 ? 497 ALA A CA  1 
ATOM   903  C C   . ALA A 1 118 ? 25.94888 1.72855   1.79021   1.000 26.60511 ? 497 ALA A C   1 
ATOM   904  O O   . ALA A 1 118 ? 26.36991 1.62343   0.63007   1.000 29.71368 ? 497 ALA A O   1 
ATOM   905  C CB  . ALA A 1 118 ? 26.10116 -0.26769  3.29365   1.000 22.08461 ? 497 ALA A CB  1 
ATOM   906  N N   . GLU A 1 119 ? 26.16426 2.80190   2.55053   1.000 25.16797 ? 498 GLU A N   1 
ATOM   907  C CA  . GLU A 1 119 ? 26.70415 4.03794   1.99894   1.000 27.52858 ? 498 GLU A CA  1 
ATOM   908  C C   . GLU A 1 119 ? 27.30342 4.90820   3.09889   1.000 35.11725 ? 498 GLU A C   1 
ATOM   909  O O   . GLU A 1 119 ? 26.60313 5.28936   4.04329   1.000 33.04093 ? 498 GLU A O   1 
ATOM   910  C CB  . GLU A 1 119 ? 25.59801 4.78811   1.24912   1.000 27.99709 ? 498 GLU A CB  1 
ATOM   911  C CG  . GLU A 1 119 ? 25.96753 6.14878   0.70103   1.000 33.97723 ? 498 GLU A CG  1 
ATOM   912  C CD  . GLU A 1 119 ? 24.97244 6.61793   -0.34361  1.000 34.88448 ? 498 GLU A CD  1 
ATOM   913  O OE1 . GLU A 1 119 ? 24.96611 6.04121   -1.45263  1.000 31.25259 ? 498 GLU A OE1 1 
ATOM   914  O OE2 . GLU A 1 119 ? 24.17767 7.53639   -0.05144  1.000 32.56384 ? 498 GLU A OE2 1 
ATOM   915  N N   . ASN A 1 120 ? 28.60202 5.20623   2.99278   1.000 29.33460 ? 499 ASN A N   1 
ATOM   916  C CA  . ASN A 1 120 ? 29.29339 6.12614   3.90187   1.000 35.92307 ? 499 ASN A CA  1 
ATOM   917  C C   . ASN A 1 120 ? 29.15564 5.69544   5.36299   1.000 34.87575 ? 499 ASN A C   1 
ATOM   918  O O   . ASN A 1 120 ? 28.85689 6.50055   6.24779   1.000 41.95719 ? 499 ASN A O   1 
ATOM   919  C CB  . ASN A 1 120 ? 28.79613 7.56024   3.70494   1.000 32.44794 ? 499 ASN A CB  1 
ATOM   920  C CG  . ASN A 1 120 ? 28.90015 8.01820   2.26226   1.000 37.02822 ? 499 ASN A CG  1 
ATOM   921  O OD1 . ASN A 1 120 ? 29.75104 7.54470   1.50650   1.000 36.70525 ? 499 ASN A OD1 1 
ATOM   922  N ND2 . ASN A 1 120 ? 28.02753 8.93946   1.87036   1.000 37.48286 ? 499 ASN A ND2 1 
ATOM   923  N N   . GLY A 1 121 ? 29.38490 4.40795   5.61296   1.000 31.62368 ? 500 GLY A N   1 
ATOM   924  C CA  . GLY A 1 121 ? 29.37218 3.87660   6.95867   1.000 33.84124 ? 500 GLY A CA  1 
ATOM   925  C C   . GLY A 1 121 ? 28.00974 3.52770   7.51571   1.000 37.06080 ? 500 GLY A C   1 
ATOM   926  O O   . GLY A 1 121 ? 27.93765 2.98929   8.62825   1.000 37.83389 ? 500 GLY A O   1 
ATOM   927  N N   . ASN A 1 122 ? 26.93064 3.80340   6.78880   1.000 31.85832 ? 501 ASN A N   1 
ATOM   928  C CA  . ASN A 1 122 ? 25.58273 3.53691   7.26498   1.000 34.64403 ? 501 ASN A CA  1 
ATOM   929  C C   . ASN A 1 122 ? 24.85985 2.59601   6.31089   1.000 35.39702 ? 501 ASN A C   1 
ATOM   930  O O   . ASN A 1 122 ? 25.23736 2.44506   5.14603   1.000 32.21947 ? 501 ASN A O   1 
ATOM   931  C CB  . ASN A 1 122 ? 24.78111 4.83596   7.41525   1.000 34.67643 ? 501 ASN A CB  1 
ATOM   932  C CG  . ASN A 1 122 ? 25.39059 5.78085   8.42850   1.000 40.04442 ? 501 ASN A CG  1 
ATOM   933  O OD1 . ASN A 1 122 ? 25.72294 5.38189   9.54412   1.000 41.98494 ? 501 ASN A OD1 1 
ATOM   934  N ND2 . ASN A 1 122 ? 25.55395 7.03931   8.04014   1.000 44.60573 ? 501 ASN A ND2 1 
ATOM   935  N N   . ILE A 1 123 ? 23.81164 1.95892   6.82103   1.000 31.32621 ? 502 ILE A N   1 
ATOM   936  C CA  . ILE A 1 123 ? 22.94207 1.12468   6.00257   1.000 31.31046 ? 502 ILE A CA  1 
ATOM   937  C C   . ILE A 1 123 ? 21.86762 2.01634   5.39839   1.000 30.74886 ? 502 ILE A C   1 
ATOM   938  O O   . ILE A 1 123 ? 21.07591 2.63160   6.12079   1.000 36.17659 ? 502 ILE A O   1 
ATOM   939  C CB  . ILE A 1 123 ? 22.32219 -0.01536  6.82179   1.000 32.70685 ? 502 ILE A CB  1 
ATOM   940  C CG1 . ILE A 1 123 ? 23.42451 -0.87171  7.44527   1.000 29.86544 ? 502 ILE A CG1 1 
ATOM   941  C CG2 . ILE A 1 123 ? 21.41270 -0.86542  5.94352   1.000 27.84041 ? 502 ILE A CG2 1 
ATOM   942  C CD1 . ILE A 1 123 ? 24.44497 -1.37124  6.44189   1.000 31.00414 ? 502 ILE A CD1 1 
ATOM   943  N N   . LEU A 1 124 ? 21.85177 2.09836   4.07046   1.000 23.89906 ? 503 LEU A N   1 
ATOM   944  C CA  . LEU A 1 124 ? 20.85808 2.91447   3.38767   1.000 23.10529 ? 503 LEU A CA  1 
ATOM   945  C C   . LEU A 1 124 ? 19.52771 2.18332   3.27363   1.000 33.63397 ? 503 LEU A C   1 
ATOM   946  O O   . LEU A 1 124 ? 18.46498 2.78641   3.46289   1.000 28.16221 ? 503 LEU A O   1 
ATOM   947  C CB  . LEU A 1 124 ? 21.37429 3.29823   2.00208   1.000 30.65309 ? 503 LEU A CB  1 
ATOM   948  C CG  . LEU A 1 124 ? 21.02371 4.64777   1.37396   1.000 39.07672 ? 503 LEU A CG  1 
ATOM   949  C CD1 . LEU A 1 124 ? 21.67985 4.72619   0.00724   1.000 28.94596 ? 503 LEU A CD1 1 
ATOM   950  C CD2 . LEU A 1 124 ? 19.51396 4.86292   1.25907   1.000 40.29976 ? 503 LEU A CD2 1 
ATOM   951  N N   . HIS A 1 125 ? 19.56664 0.88858   2.96810   1.000 28.33909 ? 504 HIS A N   1 
ATOM   952  C CA  . HIS A 1 125 ? 18.33328 0.14933   2.73376   1.000 25.84379 ? 504 HIS A CA  1 
ATOM   953  C C   . HIS A 1 125 ? 18.62405 -1.33627  2.86610   1.000 27.41534 ? 504 HIS A C   1 
ATOM   954  O O   . HIS A 1 125 ? 19.71535 -1.78540  2.51849   1.000 27.44853 ? 504 HIS A O   1 
ATOM   955  C CB  . HIS A 1 125 ? 17.76505 0.47167   1.34271   1.000 22.27109 ? 504 HIS A CB  1 
ATOM   956  C CG  . HIS A 1 125 ? 16.42523 -0.13911  1.06787   1.000 33.44354 ? 504 HIS A CG  1 
ATOM   957  N ND1 . HIS A 1 125 ? 15.29575 0.18101   1.79059   1.000 28.59312 ? 504 HIS A ND1 1 
ATOM   958  C CD2 . HIS A 1 125 ? 16.03080 -1.03407  0.13154   1.000 26.94587 ? 504 HIS A CD2 1 
ATOM   959  C CE1 . HIS A 1 125 ? 14.26603 -0.49867  1.31819   1.000 26.09869 ? 504 HIS A CE1 1 
ATOM   960  N NE2 . HIS A 1 125 ? 14.68531 -1.24534  0.31278   1.000 31.17987 ? 504 HIS A NE2 1 
ATOM   961  N N   . GLU A 1 126 ? 17.66047 -2.09184  3.38589   1.000 25.19565 ? 505 GLU A N   1 
ATOM   962  C CA  . GLU A 1 126 ? 17.82294 -3.53511  3.46488   1.000 24.78870 ? 505 GLU A CA  1 
ATOM   963  C C   . GLU A 1 126 ? 16.49517 -4.22652  3.19801   1.000 30.00990 ? 505 GLU A C   1 
ATOM   964  O O   . GLU A 1 126 ? 15.41923 -3.67751  3.44913   1.000 26.91642 ? 505 GLU A O   1 
ATOM   965  C CB  . GLU A 1 126 ? 18.39382 -3.98387  4.81777   1.000 25.87588 ? 505 GLU A CB  1 
ATOM   966  C CG  . GLU A 1 126 ? 17.54605 -3.65500  6.02970   1.000 31.44666 ? 505 GLU A CG  1 
ATOM   967  C CD  . GLU A 1 126 ? 18.31602 -3.85061  7.31929   1.000 33.76793 ? 505 GLU A CD  1 
ATOM   968  O OE1 . GLU A 1 126 ? 19.56472 -3.81246  7.27205   1.000 34.34017 ? 505 GLU A OE1 1 
ATOM   969  O OE2 . GLU A 1 126 ? 17.68045 -4.04872  8.37606   1.000 33.95247 ? 505 GLU A OE2 1 
ATOM   970  N N   . ILE A 1 127 ? 16.59843 -5.43583  2.65776   1.000 25.50752 ? 506 ILE A N   1 
ATOM   971  C CA  . ILE A 1 127 ? 15.47482 -6.31240  2.35280   1.000 28.67436 ? 506 ILE A CA  1 
ATOM   972  C C   . ILE A 1 127 ? 15.84375 -7.69971  2.86587   1.000 27.36308 ? 506 ILE A C   1 
ATOM   973  O O   . ILE A 1 127 ? 16.70308 -8.36309  2.26726   1.000 25.09489 ? 506 ILE A O   1 
ATOM   974  C CB  . ILE A 1 127 ? 15.17652 -6.35322  0.84540   1.000 26.32274 ? 506 ILE A CB  1 
ATOM   975  C CG1 . ILE A 1 127 ? 15.05724 -4.94346  0.26447   1.000 25.81978 ? 506 ILE A CG1 1 
ATOM   976  C CG2 . ILE A 1 127 ? 13.90983 -7.15138  0.57648   1.000 28.99067 ? 506 ILE A CG2 1 
ATOM   977  C CD1 . ILE A 1 127 ? 14.70586 -4.92742  -1.20858  1.000 27.76836 ? 506 ILE A CD1 1 
ATOM   978  N N   . PRO A 1 128 ? 15.25735 -8.16328  3.96843   1.000 25.03342 ? 507 PRO A N   1 
ATOM   979  C CA  . PRO A 1 128 ? 15.52030 -9.53896  4.40434   1.000 25.04748 ? 507 PRO A CA  1 
ATOM   980  C C   . PRO A 1 128 ? 15.02762 -10.52753 3.36046   1.000 24.28078 ? 507 PRO A C   1 
ATOM   981  O O   . PRO A 1 128 ? 14.15638 -10.21772 2.54471   1.000 27.64487 ? 507 PRO A O   1 
ATOM   982  C CB  . PRO A 1 128 ? 14.73335 -9.65540  5.71543   1.000 29.36500 ? 507 PRO A CB  1 
ATOM   983  C CG  . PRO A 1 128 ? 13.69146 -8.58444  5.63097   1.000 30.84651 ? 507 PRO A CG  1 
ATOM   984  C CD  . PRO A 1 128 ? 14.32529 -7.46211  4.86516   1.000 28.20697 ? 507 PRO A CD  1 
ATOM   985  N N   . LEU A 1 129 ? 15.60300 -11.73359 3.39590   1.000 25.96909 ? 508 LEU A N   1 
ATOM   986  C CA  . LEU A 1 129 ? 15.35768 -12.72228 2.34708   1.000 28.96011 ? 508 LEU A CA  1 
ATOM   987  C C   . LEU A 1 129 ? 13.86815 -12.98052 2.13619   1.000 29.17493 ? 508 LEU A C   1 
ATOM   988  O O   . LEU A 1 129 ? 13.43050 -13.24817 1.01131   1.000 32.28098 ? 508 LEU A O   1 
ATOM   989  C CB  . LEU A 1 129 ? 16.08303 -14.02664 2.68465   1.000 31.60096 ? 508 LEU A CB  1 
ATOM   990  C CG  . LEU A 1 129 ? 16.19115 -15.06376 1.56603   1.000 37.13217 ? 508 LEU A CG  1 
ATOM   991  C CD1 . LEU A 1 129 ? 17.02184 -14.50802 0.41415   1.000 26.25106 ? 508 LEU A CD1 1 
ATOM   992  C CD2 . LEU A 1 129 ? 16.78289 -16.36871 2.09203   1.000 32.36465 ? 508 LEU A CD2 1 
ATOM   993  N N   . ALA A 1 130 ? 13.07047 -12.88225 3.20279   1.000 29.35402 ? 509 ALA A N   1 
ATOM   994  C CA  . ALA A 1 130 ? 11.64133 -13.15758 3.08847   1.000 34.11071 ? 509 ALA A CA  1 
ATOM   995  C C   . ALA A 1 130 ? 10.92158 -12.11942 2.23687   1.000 31.33292 ? 509 ALA A C   1 
ATOM   996  O O   . ALA A 1 130 ? 9.86467  -12.41614 1.66845   1.000 32.34011 ? 509 ALA A O   1 
ATOM   997  C CB  . ALA A 1 130 ? 11.00616 -13.22620 4.47592   1.000 27.82934 ? 509 ALA A CB  1 
ATOM   998  N N   . LEU A 1 131 ? 11.47053 -10.91088 2.12615   1.000 29.68379 ? 510 LEU A N   1 
ATOM   999  C CA  . LEU A 1 131 ? 10.82519 -9.83046  1.39290   1.000 29.18696 ? 510 LEU A CA  1 
ATOM   1000 C C   . LEU A 1 131 ? 11.48376 -9.54066  0.04754   1.000 29.10353 ? 510 LEU A C   1 
ATOM   1001 O O   . LEU A 1 131 ? 11.08495 -8.58767  -0.62851  1.000 29.99231 ? 510 LEU A O   1 
ATOM   1002 C CB  . LEU A 1 131 ? 10.79374 -8.55942  2.24591   1.000 30.43279 ? 510 LEU A CB  1 
ATOM   1003 C CG  . LEU A 1 131 ? 9.93160  -8.63740  3.50844   1.000 29.23190 ? 510 LEU A CG  1 
ATOM   1004 C CD1 . LEU A 1 131 ? 9.90687  -7.29271  4.22666   1.000 26.66811 ? 510 LEU A CD1 1 
ATOM   1005 C CD2 . LEU A 1 131 ? 8.51580  -9.09202  3.16390   1.000 33.90467 ? 510 LEU A CD2 1 
ATOM   1006 N N   . CYS A 1 132 ? 12.47714 -10.33570 -0.36051  1.000 29.31688 ? 511 CYS A N   1 
ATOM   1007 C CA  . CYS A 1 132 ? 13.09178 -10.13508 -1.66987  1.000 25.34343 ? 511 CYS A CA  1 
ATOM   1008 C C   . CYS A 1 132 ? 12.18705 -10.61325 -2.79881  1.000 30.80384 ? 511 CYS A C   1 
ATOM   1009 O O   . CYS A 1 132 ? 12.18344 -10.01812 -3.88251  1.000 28.53972 ? 511 CYS A O   1 
ATOM   1010 C CB  . CYS A 1 132 ? 14.44281 -10.84823 -1.73243  1.000 25.10991 ? 511 CYS A CB  1 
ATOM   1011 S SG  . CYS A 1 132 ? 15.68533 -10.16763 -0.61035  1.000 23.97917 ? 511 CYS A SG  1 
ATOM   1012 N N   . GLY A 1 133 ? 11.42557 -11.68587 -2.56709  1.000 24.47316 ? 512 GLY A N   1 
ATOM   1013 C CA  . GLY A 1 133 ? 10.39324 -12.10601 -3.48540  1.000 33.29567 ? 512 GLY A CA  1 
ATOM   1014 C C   . GLY A 1 133 ? 9.09004  -12.30994 -2.73423  1.000 29.21227 ? 512 GLY A C   1 
ATOM   1015 O O   . GLY A 1 133 ? 9.06077  -12.35496 -1.50148  1.000 26.47603 ? 512 GLY A O   1 
ATOM   1016 N N   . CYS A 1 134 ? 8.00650  -12.42937 -3.49562  1.000 32.28698 ? 513 CYS A N   1 
ATOM   1017 C CA  . CYS A 1 134 ? 6.68721  -12.61654 -2.89435  1.000 34.47787 ? 513 CYS A CA  1 
ATOM   1018 C C   . CYS A 1 134 ? 6.46195  -14.10758 -2.67669  1.000 35.09115 ? 513 CYS A C   1 
ATOM   1019 O O   . CYS A 1 134 ? 5.86639  -14.79750 -3.50472  1.000 28.52854 ? 513 CYS A O   1 
ATOM   1020 C CB  . CYS A 1 134 ? 5.59622  -12.00559 -3.76269  1.000 28.25100 ? 513 CYS A CB  1 
ATOM   1021 S SG  . CYS A 1 134 ? 3.99359  -11.93268 -2.93136  1.000 38.27508 ? 513 CYS A SG  1 
ATOM   1022 N N   . ALA A 1 135 ? 6.95248  -14.61566 -1.54472  1.000 32.76738 ? 514 ALA A N   1 
ATOM   1023 C CA  . ALA A 1 135 ? 6.68548  -16.00290 -1.18547  1.000 36.29270 ? 514 ALA A CA  1 
ATOM   1024 C C   . ALA A 1 135 ? 5.27215  -16.16423 -0.64180  1.000 42.61495 ? 514 ALA A C   1 
ATOM   1025 O O   . ALA A 1 135 ? 4.59712  -17.15406 -0.94234  1.000 36.11278 ? 514 ALA A O   1 
ATOM   1026 C CB  . ALA A 1 135 ? 7.71486  -16.49247 -0.16491  1.000 28.77155 ? 514 ALA A CB  1 
ATOM   1027 N N   . SER A 1 136 ? 4.80927  -15.20179 0.15151   1.000 41.05591 ? 515 SER A N   1 
ATOM   1028 C CA  . SER A 1 136 ? 3.47023  -15.21483 0.72321   1.000 48.17115 ? 515 SER A CA  1 
ATOM   1029 C C   . SER A 1 136 ? 2.70635  -14.00068 0.21411   1.000 46.54632 ? 515 SER A C   1 
ATOM   1030 O O   . SER A 1 136 ? 3.20970  -12.87461 0.28845   1.000 47.72547 ? 515 SER A O   1 
ATOM   1031 C CB  . SER A 1 136 ? 3.53514  -15.21030 2.25212   1.000 44.07497 ? 515 SER A CB  1 
ATOM   1032 O OG  . SER A 1 136 ? 4.56863  -16.06627 2.70405   1.000 51.15788 ? 515 SER A OG  1 
ATOM   1033 N N   . SER A 1 137 ? 1.49794  -14.23243 -0.31150  1.000 47.76986 ? 516 SER A N   1 
ATOM   1034 C CA  . SER A 1 137 ? 0.68519  -13.12760 -0.81539  1.000 48.17301 ? 516 SER A CA  1 
ATOM   1035 C C   . SER A 1 137 ? 0.42069  -12.08900 0.26605   1.000 52.73442 ? 516 SER A C   1 
ATOM   1036 O O   . SER A 1 137 ? 0.32608  -10.89078 -0.03207  1.000 48.07211 ? 516 SER A O   1 
ATOM   1037 C CB  . SER A 1 137 ? -0.63414 -13.65942 -1.37222  1.000 44.06470 ? 516 SER A CB  1 
ATOM   1038 O OG  . SER A 1 137 ? -0.40464 -14.71251 -2.29141  1.000 46.23781 ? 516 SER A OG  1 
ATOM   1039 N N   . GLU A 1 138 ? 0.31749  -12.53225 1.52303   1.000 45.32817 ? 517 GLU A N   1 
ATOM   1040 C CA  . GLU A 1 138 ? 0.12653  -11.62382 2.64927   1.000 59.52860 ? 517 GLU A CA  1 
ATOM   1041 C C   . GLU A 1 138 ? 1.13444  -10.47916 2.62770   1.000 61.74494 ? 517 GLU A C   1 
ATOM   1042 O O   . GLU A 1 138 ? 0.80385  -9.34120  2.98018   1.000 60.49075 ? 517 GLU A O   1 
ATOM   1043 C CB  . GLU A 1 138 ? 0.24175  -12.41245 3.95523   1.000 59.52448 ? 517 GLU A CB  1 
ATOM   1044 C CG  . GLU A 1 138 ? -0.25058 -11.69016 5.19546   1.000 71.58242 ? 517 GLU A CG  1 
ATOM   1045 C CD  . GLU A 1 138 ? -0.45639 -12.63464 6.36755   1.000 76.90830 ? 517 GLU A CD  1 
ATOM   1046 O OE1 . GLU A 1 138 ? 0.54705  -13.10248 6.94727   1.000 77.89642 ? 517 GLU A OE1 1 
ATOM   1047 O OE2 . GLU A 1 138 ? -1.62613 -12.92433 6.69598   1.000 78.76172 ? 517 GLU A OE2 1 
ATOM   1048 N N   . ALA A 1 139 ? 2.36280  -10.75635 2.19351   1.000 56.15604 ? 518 ALA A N   1 
ATOM   1049 C CA  . ALA A 1 139 ? 3.44521  -9.78310  2.23466   1.000 48.77316 ? 518 ALA A CA  1 
ATOM   1050 C C   . ALA A 1 139 ? 3.62680  -9.01628  0.93130   1.000 45.90046 ? 518 ALA A C   1 
ATOM   1051 O O   . ALA A 1 139 ? 4.53707  -8.18096  0.85850   1.000 46.70880 ? 518 ALA A O   1 
ATOM   1052 C CB  . ALA A 1 139 ? 4.75932  -10.47943 2.59857   1.000 49.53214 ? 518 ALA A CB  1 
ATOM   1053 N N   . TYR A 1 140 ? 2.78545  -9.26844  -0.08158  1.000 46.39605 ? 519 TYR A N   1 
ATOM   1054 C CA  . TYR A 1 140 ? 2.94685  -8.65328  -1.39797  1.000 42.60977 ? 519 TYR A CA  1 
ATOM   1055 C C   . TYR A 1 140 ? 3.33648  -7.18372  -1.29634  1.000 46.12745 ? 519 TYR A C   1 
ATOM   1056 O O   . TYR A 1 140 ? 4.43291  -6.78687  -1.71462  1.000 45.70634 ? 519 TYR A O   1 
ATOM   1057 C CB  . TYR A 1 140 ? 1.65647  -8.80207  -2.21451  1.000 44.44838 ? 519 TYR A CB  1 
ATOM   1058 C CG  . TYR A 1 140 ? 1.70397  -8.11499  -3.56716  1.000 45.92069 ? 519 TYR A CG  1 
ATOM   1059 C CD1 . TYR A 1 140 ? 0.99989  -6.93856  -3.80077  1.000 50.74652 ? 519 TYR A CD1 1 
ATOM   1060 C CD2 . TYR A 1 140 ? 2.45918  -8.64023  -4.60781  1.000 47.31094 ? 519 TYR A CD2 1 
ATOM   1061 C CE1 . TYR A 1 140 ? 1.04512  -6.30764  -5.03667  1.000 49.79499 ? 519 TYR A CE1 1 
ATOM   1062 C CE2 . TYR A 1 140 ? 2.51114  -8.01595  -5.84492  1.000 49.42035 ? 519 TYR A CE2 1 
ATOM   1063 C CZ  . TYR A 1 140 ? 1.80272  -6.85135  -6.05323  1.000 52.78616 ? 519 TYR A CZ  1 
ATOM   1064 O OH  . TYR A 1 140 ? 1.85140  -6.23052  -7.28074  1.000 55.27641 ? 519 TYR A OH  1 
ATOM   1065 N N   . GLU A 1 141 ? 2.45179  -6.37899  -0.69836  1.000 48.11930 ? 520 GLU A N   1 
ATOM   1066 C CA  . GLU A 1 141 ? 2.70243  -4.94814  -0.55349  1.000 48.44106 ? 520 GLU A CA  1 
ATOM   1067 C C   . GLU A 1 141 ? 4.10819  -4.68338  -0.03204  1.000 44.11924 ? 520 GLU A C   1 
ATOM   1068 O O   . GLU A 1 141 ? 4.90647  -4.00486  -0.69274  1.000 45.70409 ? 520 GLU A O   1 
ATOM   1069 C CB  . GLU A 1 141 ? 1.65854  -4.32590  0.37516   1.000 48.30894 ? 520 GLU A CB  1 
ATOM   1070 C CG  . GLU A 1 141 ? 0.21351  -4.60787  -0.01017  1.000 49.81857 ? 520 GLU A CG  1 
ATOM   1071 C CD  . GLU A 1 141 ? -0.21127 -3.90392  -1.28687  1.000 56.35643 ? 520 GLU A CD  1 
ATOM   1072 O OE1 . GLU A 1 141 ? -1.32982 -4.17807  -1.77017  1.000 60.69405 ? 520 GLU A OE1 1 
ATOM   1073 O OE2 . GLU A 1 141 ? 0.56631  -3.07685  -1.81091  1.000 57.98216 ? 520 GLU A OE2 1 
ATOM   1074 N N   . ASP A 1 142 ? 4.43955  -5.24559  1.13600   1.000 41.15689 ? 521 ASP A N   1 
ATOM   1075 C CA  . ASP A 1 142 ? 5.76482  -5.03277  1.70895   1.000 43.28755 ? 521 ASP A CA  1 
ATOM   1076 C C   . ASP A 1 142 ? 6.84644  -5.31732  0.67971   1.000 40.11361 ? 521 ASP A C   1 
ATOM   1077 O O   . ASP A 1 142 ? 7.68569  -4.45204  0.39357   1.000 38.37593 ? 521 ASP A O   1 
ATOM   1078 C CB  . ASP A 1 142 ? 5.95175  -5.90202  2.95187   1.000 45.28771 ? 521 ASP A CB  1 
ATOM   1079 C CG  . ASP A 1 142 ? 5.23178  -5.34455  4.16431   1.000 51.88311 ? 521 ASP A CG  1 
ATOM   1080 O OD1 . ASP A 1 142 ? 5.20054  -4.10465  4.32369   1.000 49.30152 ? 521 ASP A OD1 1 
ATOM   1081 O OD2 . ASP A 1 142 ? 4.69596  -6.14669  4.95672   1.000 52.95962 ? 521 ASP A OD2 1 
ATOM   1082 N N   . VAL A 1 143 ? 6.79896  -6.50644  0.06660   1.000 41.91971 ? 522 VAL A N   1 
ATOM   1083 C CA  . VAL A 1 143 ? 7.74251  -6.84533  -0.99734  1.000 37.49719 ? 522 VAL A CA  1 
ATOM   1084 C C   . VAL A 1 143 ? 7.83848  -5.69173  -1.98336  1.000 39.54946 ? 522 VAL A C   1 
ATOM   1085 O O   . VAL A 1 143 ? 8.89518  -5.06022  -2.13249  1.000 31.25313 ? 522 VAL A O   1 
ATOM   1086 C CB  . VAL A 1 143 ? 7.32263  -8.14737  -1.70011  1.000 33.29420 ? 522 VAL A CB  1 
ATOM   1087 C CG1 . VAL A 1 143 ? 8.23862  -8.43167  -2.88013  1.000 30.20105 ? 522 VAL A CG1 1 
ATOM   1088 C CG2 . VAL A 1 143 ? 7.33327  -9.30542  -0.71880  1.000 34.10576 ? 522 VAL A CG2 1 
ATOM   1089 N N   . LEU A 1 144 ? 6.70314  -5.36254  -2.61165  1.000 41.20823 ? 523 LEU A N   1 
ATOM   1090 C CA  . LEU A 1 144 ? 6.65088  -4.25560  -3.55938  1.000 40.81970 ? 523 LEU A CA  1 
ATOM   1091 C C   . LEU A 1 144 ? 7.38676  -3.04266  -3.01211  1.000 34.40961 ? 523 LEU A C   1 
ATOM   1092 O O   . LEU A 1 144 ? 8.34986  -2.56029  -3.62126  1.000 35.40100 ? 523 LEU A O   1 
ATOM   1093 C CB  . LEU A 1 144 ? 5.19513  -3.90440  -3.87445  1.000 45.48503 ? 523 LEU A CB  1 
ATOM   1094 C CG  . LEU A 1 144 ? 4.92665  -3.09551  -5.14742  1.000 49.82228 ? 523 LEU A CG  1 
ATOM   1095 C CD1 . LEU A 1 144 ? 4.69508  -4.01715  -6.33895  1.000 56.15638 ? 523 LEU A CD1 1 
ATOM   1096 C CD2 . LEU A 1 144 ? 3.75064  -2.14753  -4.95762  1.000 48.38761 ? 523 LEU A CD2 1 
ATOM   1097 N N   . GLU A 1 145 ? 6.98576  -2.57949  -1.82316  1.000 34.67187 ? 524 GLU A N   1 
ATOM   1098 C CA  . GLU A 1 145 ? 7.62678  -1.40845  -1.23639  1.000 40.33227 ? 524 GLU A CA  1 
ATOM   1099 C C   . GLU A 1 145 ? 9.13373  -1.60133  -1.17886  1.000 36.01948 ? 524 GLU A C   1 
ATOM   1100 O O   . GLU A 1 145 ? 9.88735  -0.86489  -1.82949  1.000 36.54806 ? 524 GLU A O   1 
ATOM   1101 C CB  . GLU A 1 145 ? 7.05157  -1.12871  0.15504   1.000 41.96492 ? 524 GLU A CB  1 
ATOM   1102 C CG  . GLU A 1 145 ? 7.73367  0.01413   0.89747   1.000 45.43133 ? 524 GLU A CG  1 
ATOM   1103 C CD  . GLU A 1 145 ? 6.87609  0.59169   2.01195   1.000 64.44298 ? 524 GLU A CD  1 
ATOM   1104 O OE1 . GLU A 1 145 ? 6.36741  1.72055   1.84585   1.000 70.99332 ? 524 GLU A OE1 1 
ATOM   1105 O OE2 . GLU A 1 145 ? 6.70390  -0.08361  3.04933   1.000 70.25902 ? 524 GLU A OE2 1 
ATOM   1106 N N   . LYS A 1 146 ? 9.58085  -2.64942  -0.47388  1.000 31.86487 ? 525 LYS A N   1 
ATOM   1107 C CA  . LYS A 1 146 ? 11.00958 -2.91929  -0.33999  1.000 34.31103 ? 525 LYS A CA  1 
ATOM   1108 C C   . LYS A 1 146 ? 11.69189 -2.91537  -1.69485  1.000 31.59694 ? 525 LYS A C   1 
ATOM   1109 O O   . LYS A 1 146 ? 12.79956 -2.38613  -1.84729  1.000 29.85491 ? 525 LYS A O   1 
ATOM   1110 C CB  . LYS A 1 146 ? 11.22663 -4.26701  0.35005   1.000 32.64380 ? 525 LYS A CB  1 
ATOM   1111 C CG  . LYS A 1 146 ? 11.02031 -4.24757  1.84914   1.000 33.90382 ? 525 LYS A CG  1 
ATOM   1112 C CD  . LYS A 1 146 ? 12.20392 -3.61525  2.55038   1.000 33.56127 ? 525 LYS A CD  1 
ATOM   1113 C CE  . LYS A 1 146 ? 11.94150 -3.47486  4.03596   1.000 30.36104 ? 525 LYS A CE  1 
ATOM   1114 N NZ  . LYS A 1 146 ? 13.10604 -2.89453  4.75810   1.000 30.63691 ? 525 LYS A NZ  1 
ATOM   1115 N N   . GLU A 1 147 ? 11.02271 -3.48013  -2.69851  1.000 29.53389 ? 526 GLU A N   1 
ATOM   1116 C CA  . GLU A 1 147 ? 11.59472 -3.52246  -4.03385  1.000 32.48695 ? 526 GLU A CA  1 
ATOM   1117 C C   . GLU A 1 147 ? 11.68450 -2.12743  -4.63001  1.000 36.64930 ? 526 GLU A C   1 
ATOM   1118 O O   . GLU A 1 147 ? 12.77472 -1.67675  -5.00700  1.000 30.67157 ? 526 GLU A O   1 
ATOM   1119 C CB  . GLU A 1 147 ? 10.74908 -4.43417  -4.91459  1.000 39.30822 ? 526 GLU A CB  1 
ATOM   1120 C CG  . GLU A 1 147 ? 11.32627 -4.74048  -6.26848  1.000 45.77805 ? 526 GLU A CG  1 
ATOM   1121 C CD  . GLU A 1 147 ? 10.42267 -5.66879  -7.04731  1.000 58.15897 ? 526 GLU A CD  1 
ATOM   1122 O OE1 . GLU A 1 147 ? 9.30713  -5.23858  -7.41286  1.000 58.22835 ? 526 GLU A OE1 1 
ATOM   1123 O OE2 . GLU A 1 147 ? 10.81367 -6.83385  -7.27006  1.000 59.71610 ? 526 GLU A OE2 1 
ATOM   1124 N N   . GLN A 1 148 ? 10.55244 -1.41614  -4.68523  1.000 32.23458 ? 527 GLN A N   1 
ATOM   1125 C CA  . GLN A 1 148 ? 10.51877 -0.13877  -5.38900  1.000 38.68964 ? 527 GLN A CA  1 
ATOM   1126 C C   . GLN A 1 148 ? 11.54211 0.82318   -4.81015  1.000 32.02931 ? 527 GLN A C   1 
ATOM   1127 O O   . GLN A 1 148 ? 12.36096 1.38438   -5.55083  1.000 37.45209 ? 527 GLN A O   1 
ATOM   1128 C CB  . GLN A 1 148 ? 9.11229  0.46048   -5.33102  1.000 40.04438 ? 527 GLN A CB  1 
ATOM   1129 C CG  . GLN A 1 148 ? 8.87921  1.64092   -6.27602  1.000 42.95039 ? 527 GLN A CG  1 
ATOM   1130 C CD  . GLN A 1 148 ? 8.64280  1.21736   -7.72087  1.000 56.34541 ? 527 GLN A CD  1 
ATOM   1131 O OE1 . GLN A 1 148 ? 8.80162  0.04731   -8.07675  1.000 57.34431 ? 527 GLN A OE1 1 
ATOM   1132 N NE2 . GLN A 1 148 ? 8.25437  2.17413   -8.55953  1.000 59.81557 ? 527 GLN A NE2 1 
ATOM   1133 N N   . LYS A 1 149 ? 11.53248 0.98810   -3.48467  1.000 29.19792 ? 528 LYS A N   1 
ATOM   1134 C CA  . LYS A 1 149 ? 12.54653 1.79767   -2.82190  1.000 32.03608 ? 528 LYS A CA  1 
ATOM   1135 C C   . LYS A 1 149 ? 13.94161 1.42619   -3.30589  1.000 35.29211 ? 528 LYS A C   1 
ATOM   1136 O O   . LYS A 1 149 ? 14.69095 2.29006   -3.78179  1.000 30.91604 ? 528 LYS A O   1 
ATOM   1137 C CB  . LYS A 1 149 ? 12.42947 1.64278   -1.30403  1.000 27.93130 ? 528 LYS A CB  1 
ATOM   1138 C CG  . LYS A 1 149 ? 13.42033 2.48975   -0.51325  1.000 34.91550 ? 528 LYS A CG  1 
ATOM   1139 C CD  . LYS A 1 149 ? 13.48188 3.92121   -1.03871  1.000 44.95115 ? 528 LYS A CD  1 
ATOM   1140 C CE  . LYS A 1 149 ? 12.15199 4.65249   -0.88637  1.000 52.88134 ? 528 LYS A CE  1 
ATOM   1141 N NZ  . LYS A 1 149 ? 11.99735 5.69753   -1.93976  1.000 47.17283 ? 528 LYS A NZ  1 
ATOM   1142 N N   . LEU A 1 150 ? 14.29128 0.13457   -3.23550  1.000 30.45697 ? 529 LEU A N   1 
ATOM   1143 C CA  . LEU A 1 150 ? 15.59385 -0.29994  -3.73070  1.000 25.26905 ? 529 LEU A CA  1 
ATOM   1144 C C   . LEU A 1 150 ? 15.83505 0.23919   -5.13169  1.000 26.70220 ? 529 LEU A C   1 
ATOM   1145 O O   . LEU A 1 150 ? 16.80775 0.97085   -5.36573  1.000 23.81129 ? 529 LEU A O   1 
ATOM   1146 C CB  . LEU A 1 150 ? 15.69900 -1.82620  -3.71121  1.000 27.81914 ? 529 LEU A CB  1 
ATOM   1147 C CG  . LEU A 1 150 ? 17.01997 -2.37694  -4.26558  1.000 24.99189 ? 529 LEU A CG  1 
ATOM   1148 C CD1 . LEU A 1 150 ? 18.21360 -1.83537  -3.48638  1.000 20.99891 ? 529 LEU A CD1 1 
ATOM   1149 C CD2 . LEU A 1 150 ? 17.03735 -3.90328  -4.27127  1.000 23.83642 ? 529 LEU A CD2 1 
ATOM   1150 N N   . ARG A 1 151 ? 14.90833 -0.04998  -6.05506  1.000 23.79217 ? 530 ARG A N   1 
ATOM   1151 C CA  . ARG A 1 151 ? 14.99807 0.49192   -7.40655  1.000 30.17496 ? 530 ARG A CA  1 
ATOM   1152 C C   . ARG A 1 151 ? 15.35018 1.96807   -7.36978  1.000 31.27429 ? 530 ARG A C   1 
ATOM   1153 O O   . ARG A 1 151 ? 16.40556 2.37928   -7.86953  1.000 32.68079 ? 530 ARG A O   1 
ATOM   1154 C CB  . ARG A 1 151 ? 13.67979 0.28879   -8.15371  1.000 37.62192 ? 530 ARG A CB  1 
ATOM   1155 C CG  . ARG A 1 151 ? 13.32279 -1.14853  -8.43977  1.000 42.11949 ? 530 ARG A CG  1 
ATOM   1156 C CD  . ARG A 1 151 ? 12.56523 -1.25197  -9.75036  1.000 51.76154 ? 530 ARG A CD  1 
ATOM   1157 N NE  . ARG A 1 151 ? 11.52054 -2.26553  -9.69830  1.000 64.72450 ? 530 ARG A NE  1 
ATOM   1158 C CZ  . ARG A 1 151 ? 11.74061 -3.57245  -9.73478  1.000 66.90992 ? 530 ARG A CZ  1 
ATOM   1159 N NH1 . ARG A 1 151 ? 12.96791 -4.06836  -9.76369  1.000 66.09970 ? 530 ARG A NH1 1 
ATOM   1160 N NH2 . ARG A 1 151 ? 10.70384 -4.40361  -9.74636  1.000 69.97970 ? 530 ARG A NH2 1 
ATOM   1161 N N   . ASP A 1 152 ? 14.50034 2.76701   -6.71453  1.000 31.85697 ? 531 ASP A N   1 
ATOM   1162 C CA  . ASP A 1 152 ? 14.71204 4.20799   -6.65801  1.000 29.03441 ? 531 ASP A CA  1 
ATOM   1163 C C   . ASP A 1 152 ? 16.14811 4.52782   -6.27845  1.000 28.10197 ? 531 ASP A C   1 
ATOM   1164 O O   . ASP A 1 152 ? 16.86020 5.21463   -7.02127  1.000 29.57145 ? 531 ASP A O   1 
ATOM   1165 C CB  . ASP A 1 152 ? 13.73004 4.84009   -5.67064  1.000 35.97097 ? 531 ASP A CB  1 
ATOM   1166 C CG  . ASP A 1 152 ? 12.28957 4.73109   -6.13705  1.000 35.53926 ? 531 ASP A CG  1 
ATOM   1167 O OD1 . ASP A 1 152 ? 12.07426 4.31790   -7.29727  1.000 36.30387 ? 531 ASP A OD1 1 
ATOM   1168 O OD2 . ASP A 1 152 ? 11.37786 5.05799   -5.34885  1.000 41.13055 ? 531 ASP A OD2 1 
ATOM   1169 N N   . LEU A 1 153 ? 16.61442 3.96615   -5.15947  1.000 26.12302 ? 532 LEU A N   1 
ATOM   1170 C CA  . LEU A 1 153 ? 17.96647 4.26346   -4.70476  1.000 25.95187 ? 532 LEU A CA  1 
ATOM   1171 C C   . LEU A 1 153 ? 18.98754 3.88884   -5.76798  1.000 26.63187 ? 532 LEU A C   1 
ATOM   1172 O O   . LEU A 1 153 ? 19.82012 4.71720   -6.15724  1.000 32.26804 ? 532 LEU A O   1 
ATOM   1173 C CB  . LEU A 1 153 ? 18.24023 3.54175   -3.38589  1.000 25.14304 ? 532 LEU A CB  1 
ATOM   1174 C CG  . LEU A 1 153 ? 17.28693 4.03751   -2.29446  1.000 31.84588 ? 532 LEU A CG  1 
ATOM   1175 C CD1 . LEU A 1 153 ? 17.27785 3.11376   -1.09144  1.000 25.08826 ? 532 LEU A CD1 1 
ATOM   1176 C CD2 . LEU A 1 153 ? 17.66264 5.44989   -1.87179  1.000 30.58496 ? 532 LEU A CD2 1 
ATOM   1177 N N   . LEU A 1 154 ? 18.89531 2.66633   -6.29946  1.000 25.84723 ? 533 LEU A N   1 
ATOM   1178 C CA  . LEU A 1 154 ? 19.83160 2.24904   -7.33592  1.000 26.83414 ? 533 LEU A CA  1 
ATOM   1179 C C   . LEU A 1 154 ? 19.72523 3.13366   -8.57004  1.000 26.52619 ? 533 LEU A C   1 
ATOM   1180 O O   . LEU A 1 154 ? 20.73901 3.40363   -9.22297  1.000 21.82782 ? 533 LEU A O   1 
ATOM   1181 C CB  . LEU A 1 154 ? 19.59896 0.78074   -7.69837  1.000 22.87586 ? 533 LEU A CB  1 
ATOM   1182 C CG  . LEU A 1 154 ? 19.91256 -0.22793  -6.58884  1.000 24.57885 ? 533 LEU A CG  1 
ATOM   1183 C CD1 . LEU A 1 154 ? 19.62057 -1.64298  -7.05060  1.000 24.16245 ? 533 LEU A CD1 1 
ATOM   1184 C CD2 . LEU A 1 154 ? 21.35613 -0.09788  -6.13490  1.000 23.54399 ? 533 LEU A CD2 1 
ATOM   1185 N N   . THR A 1 155 ? 18.51972 3.61115   -8.89352  1.000 27.53486 ? 534 THR A N   1 
ATOM   1186 C CA  . THR A 1 155 ? 18.37995 4.50377   -10.03842 1.000 30.90647 ? 534 THR A CA  1 
ATOM   1187 C C   . THR A 1 155 ? 19.04021 5.84698   -9.75797  1.000 28.72733 ? 534 THR A C   1 
ATOM   1188 O O   . THR A 1 155 ? 19.62303 6.45923   -10.66028 1.000 31.94986 ? 534 THR A O   1 
ATOM   1189 C CB  . THR A 1 155 ? 16.90294 4.68829   -10.39627 1.000 32.72130 ? 534 THR A CB  1 
ATOM   1190 O OG1 . THR A 1 155 ? 16.32263 3.41821   -10.72229 1.000 32.94277 ? 534 THR A OG1 1 
ATOM   1191 C CG2 . THR A 1 155 ? 16.75875 5.62185   -11.59498 1.000 31.83621 ? 534 THR A CG2 1 
ATOM   1192 N N   . GLU A 1 156 ? 18.97764 6.30970   -8.50511  1.000 25.72838 ? 535 GLU A N   1 
ATOM   1193 C CA  . GLU A 1 156 ? 19.63231 7.56295   -8.14678  1.000 32.37664 ? 535 GLU A CA  1 
ATOM   1194 C C   . GLU A 1 156 ? 21.14094 7.46440   -8.30269  1.000 33.40838 ? 535 GLU A C   1 
ATOM   1195 O O   . GLU A 1 156 ? 21.80473 8.47013   -8.57966  1.000 32.09969 ? 535 GLU A O   1 
ATOM   1196 C CB  . GLU A 1 156 ? 19.28591 7.94580   -6.70833  1.000 32.62194 ? 535 GLU A CB  1 
ATOM   1197 C CG  . GLU A 1 156 ? 17.82595 8.25414   -6.47145  1.000 40.35858 ? 535 GLU A CG  1 
ATOM   1198 C CD  . GLU A 1 156 ? 17.47894 8.29341   -4.99585  1.000 46.50075 ? 535 GLU A CD  1 
ATOM   1199 O OE1 . GLU A 1 156 ? 16.38749 7.80877   -4.63168  1.000 57.98703 ? 535 GLU A OE1 1 
ATOM   1200 O OE2 . GLU A 1 156 ? 18.29690 8.80101   -4.19841  1.000 50.50970 ? 535 GLU A OE2 1 
ATOM   1201 N N   . ARG A 1 157 ? 21.69562 6.26233   -8.14386  1.000 31.51331 ? 536 ARG A N   1 
ATOM   1202 C CA  . ARG A 1 157 ? 23.13480 6.05653   -8.10932  1.000 25.36152 ? 536 ARG A CA  1 
ATOM   1203 C C   . ARG A 1 157 ? 23.68628 5.49330   -9.41475  1.000 24.56081 ? 536 ARG A C   1 
ATOM   1204 O O   . ARG A 1 157 ? 24.82706 5.02093   -9.44289  1.000 26.33918 ? 536 ARG A O   1 
ATOM   1205 C CB  . ARG A 1 157 ? 23.49897 5.15875   -6.92552  1.000 24.84548 ? 536 ARG A CB  1 
ATOM   1206 C CG  . ARG A 1 157 ? 23.44297 5.89921   -5.59840  1.000 28.73153 ? 536 ARG A CG  1 
ATOM   1207 C CD  . ARG A 1 157 ? 22.97779 5.02554   -4.45038  1.000 29.16803 ? 536 ARG A CD  1 
ATOM   1208 N NE  . ARG A 1 157 ? 22.79864 5.82185   -3.24296  1.000 26.78168 ? 536 ARG A NE  1 
ATOM   1209 C CZ  . ARG A 1 157 ? 21.73467 6.57218   -2.99151  1.000 30.33849 ? 536 ARG A CZ  1 
ATOM   1210 N NH1 . ARG A 1 157 ? 20.70806 6.61799   -3.82482  1.000 21.92388 ? 536 ARG A NH1 1 
ATOM   1211 N NH2 . ARG A 1 157 ? 21.70229 7.30067   -1.88024  1.000 28.35316 ? 536 ARG A NH2 1 
ATOM   1212 N N   . GLY A 1 158 ? 22.90795 5.53788   -10.49554 1.000 25.13112 ? 537 GLY A N   1 
ATOM   1213 C CA  . GLY A 1 158 ? 23.42877 5.25792   -11.81967 1.000 28.01822 ? 537 GLY A CA  1 
ATOM   1214 C C   . GLY A 1 158 ? 22.91156 4.00559   -12.49403 1.000 26.93702 ? 537 GLY A C   1 
ATOM   1215 O O   . GLY A 1 158 ? 23.32448 3.72742   -13.62681 1.000 27.92017 ? 537 GLY A O   1 
ATOM   1216 N N   . TYR A 1 159 ? 22.03329 3.23494   -11.85774 1.000 26.11278 ? 538 TYR A N   1 
ATOM   1217 C CA  . TYR A 1 159 ? 21.46576 2.06309   -12.51618 1.000 29.27736 ? 538 TYR A CA  1 
ATOM   1218 C C   . TYR A 1 159 ? 20.38992 2.52796   -13.48851 1.000 29.51116 ? 538 TYR A C   1 
ATOM   1219 O O   . TYR A 1 159 ? 19.33647 3.01954   -13.07133 1.000 30.03866 ? 538 TYR A O   1 
ATOM   1220 C CB  . TYR A 1 159 ? 20.90121 1.07077   -11.50467 1.000 23.35861 ? 538 TYR A CB  1 
ATOM   1221 C CG  . TYR A 1 159 ? 20.46583 -0.21708  -12.16598 1.000 26.18066 ? 538 TYR A CG  1 
ATOM   1222 C CD1 . TYR A 1 159 ? 19.16378 -0.38335  -12.61648 1.000 23.84225 ? 538 TYR A CD1 1 
ATOM   1223 C CD2 . TYR A 1 159 ? 21.36496 -1.25613  -12.36782 1.000 20.88395 ? 538 TYR A CD2 1 
ATOM   1224 C CE1 . TYR A 1 159 ? 18.76561 -1.55072  -13.23457 1.000 23.26964 ? 538 TYR A CE1 1 
ATOM   1225 C CE2 . TYR A 1 159 ? 20.97315 -2.43080  -12.98542 1.000 22.29358 ? 538 TYR A CE2 1 
ATOM   1226 C CZ  . TYR A 1 159 ? 19.67100 -2.57062  -13.41833 1.000 26.11367 ? 538 TYR A CZ  1 
ATOM   1227 O OH  . TYR A 1 159 ? 19.26674 -3.73228  -14.03732 1.000 24.09271 ? 538 TYR A OH  1 
ATOM   1228 N N   . GLU A 1 160 ? 20.64904 2.36615   -14.78544 1.000 29.15208 ? 539 GLU A N   1 
ATOM   1229 C CA  . GLU A 1 160 ? 19.77549 2.89084   -15.82510 1.000 30.67088 ? 539 GLU A CA  1 
ATOM   1230 C C   . GLU A 1 160 ? 19.00731 1.81507   -16.57682 1.000 33.18555 ? 539 GLU A C   1 
ATOM   1231 O O   . GLU A 1 160 ? 18.29261 2.13955   -17.53093 1.000 33.23565 ? 539 GLU A O   1 
ATOM   1232 C CB  . GLU A 1 160 ? 20.58512 3.71891   -16.82658 1.000 29.64623 ? 539 GLU A CB  1 
ATOM   1233 C CG  . GLU A 1 160 ? 21.25358 4.94182   -16.23663 1.000 35.33539 ? 539 GLU A CG  1 
ATOM   1234 C CD  . GLU A 1 160 ? 22.05940 5.69892   -17.27197 1.000 40.93519 ? 539 GLU A CD  1 
ATOM   1235 O OE1 . GLU A 1 160 ? 22.23113 5.16943   -18.39085 1.000 45.63497 ? 539 GLU A OE1 1 
ATOM   1236 O OE2 . GLU A 1 160 ? 22.51725 6.82034   -16.97097 1.000 50.26951 ? 539 GLU A OE2 1 
ATOM   1237 N N   . PHE A 1 161 ? 19.13484 0.55278   -16.19095 1.000 26.71850 ? 540 PHE A N   1 
ATOM   1238 C CA  . PHE A 1 161 ? 18.42488 -0.51720  -16.86695 1.000 29.86043 ? 540 PHE A CA  1 
ATOM   1239 C C   . PHE A 1 161 ? 17.13264 -0.82488  -16.11083 1.000 30.64145 ? 540 PHE A C   1 
ATOM   1240 O O   . PHE A 1 161 ? 16.79443 -0.17517  -15.11890 1.000 32.41656 ? 540 PHE A O   1 
ATOM   1241 C CB  . PHE A 1 161 ? 19.34619 -1.72698  -17.02903 1.000 27.06012 ? 540 PHE A CB  1 
ATOM   1242 C CG  . PHE A 1 161 ? 20.58541 -1.42249  -17.83213 1.000 29.47787 ? 540 PHE A CG  1 
ATOM   1243 C CD1 . PHE A 1 161 ? 20.51597 -1.28604  -19.20972 1.000 28.45871 ? 540 PHE A CD1 1 
ATOM   1244 C CD2 . PHE A 1 161 ? 21.81056 -1.24205  -17.20941 1.000 29.73228 ? 540 PHE A CD2 1 
ATOM   1245 C CE1 . PHE A 1 161 ? 21.64445 -0.99328  -19.95201 1.000 27.87412 ? 540 PHE A CE1 1 
ATOM   1246 C CE2 . PHE A 1 161 ? 22.94408 -0.94899  -17.94945 1.000 28.17585 ? 540 PHE A CE2 1 
ATOM   1247 C CZ  . PHE A 1 161 ? 22.85776 -0.82610  -19.32361 1.000 24.81436 ? 540 PHE A CZ  1 
ATOM   1248 N N   . CYS A 1 162 ? 16.38744 -1.81783  -16.59691 1.000 35.08648 ? 541 CYS A N   1 
ATOM   1249 C CA  . CYS A 1 162 ? 14.99279 -1.93710  -16.18503 1.000 29.51019 ? 541 CYS A CA  1 
ATOM   1250 C C   . CYS A 1 162 ? 14.81866 -2.60386  -14.82553 1.000 33.26455 ? 541 CYS A C   1 
ATOM   1251 O O   . CYS A 1 162 ? 13.85933 -2.28901  -14.11160 1.000 35.62885 ? 541 CYS A O   1 
ATOM   1252 C CB  . CYS A 1 162 ? 14.19549 -2.70707  -17.23653 1.000 32.29508 ? 541 CYS A CB  1 
ATOM   1253 S SG  . CYS A 1 162 ? 12.41041 -2.60979  -16.98408 1.000 38.25592 ? 541 CYS A SG  1 
ATOM   1254 N N   . ASP A 1 163 ? 15.70858 -3.51804  -14.44846 1.000 26.20799 ? 542 ASP A N   1 
ATOM   1255 C CA  . ASP A 1 163 ? 15.45334 -4.32908  -13.26421 1.000 24.25899 ? 542 ASP A CA  1 
ATOM   1256 C C   . ASP A 1 163 ? 16.75858 -4.86890  -12.69035 1.000 27.18249 ? 542 ASP A C   1 
ATOM   1257 O O   . ASP A 1 163 ? 17.32985 -5.82016  -13.23898 1.000 23.04371 ? 542 ASP A O   1 
ATOM   1258 C CB  . ASP A 1 163 ? 14.50488 -5.47687  -13.62245 1.000 25.87553 ? 542 ASP A CB  1 
ATOM   1259 C CG  . ASP A 1 163 ? 14.05213 -6.27455  -12.41236 1.000 25.30569 ? 542 ASP A CG  1 
ATOM   1260 O OD1 . ASP A 1 163 ? 14.45887 -5.94776  -11.27790 1.000 30.37462 ? 542 ASP A OD1 1 
ATOM   1261 O OD2 . ASP A 1 163 ? 13.27774 -7.23443  -12.60216 1.000 32.01959 ? 542 ASP A OD2 1 
ATOM   1262 N N   . PRO A 1 164 ? 17.25194 -4.30482  -11.58295 1.000 26.59132 ? 543 PRO A N   1 
ATOM   1263 C CA  . PRO A 1 164 ? 18.52469 -4.79322  -11.02648 1.000 24.04300 ? 543 PRO A CA  1 
ATOM   1264 C C   . PRO A 1 164 ? 18.44571 -6.20061  -10.45924 1.000 21.16597 ? 543 PRO A C   1 
ATOM   1265 O O   . PRO A 1 164 ? 19.46482 -6.90429  -10.44516 1.000 21.08151 ? 543 PRO A O   1 
ATOM   1266 C CB  . PRO A 1 164 ? 18.84631 -3.76404  -9.93478  1.000 21.21233 ? 543 PRO A CB  1 
ATOM   1267 C CG  . PRO A 1 164 ? 17.52490 -3.18723  -9.55693  1.000 25.90316 ? 543 PRO A CG  1 
ATOM   1268 C CD  . PRO A 1 164 ? 16.69715 -3.18123  -10.80775 1.000 29.07199 ? 543 PRO A CD  1 
ATOM   1269 N N   . ILE A 1 165 ? 17.27517 -6.63253  -9.98291  1.000 26.96627 ? 544 ILE A N   1 
ATOM   1270 C CA  . ILE A 1 165 ? 17.14965 -7.98801  -9.45375  1.000 21.06835 ? 544 ILE A CA  1 
ATOM   1271 C C   . ILE A 1 165 ? 17.35233 -9.01266  -10.56307 1.000 20.04752 ? 544 ILE A C   1 
ATOM   1272 O O   . ILE A 1 165 ? 17.98806 -10.05133 -10.35725 1.000 21.35110 ? 544 ILE A O   1 
ATOM   1273 C CB  . ILE A 1 165 ? 15.79001 -8.16625  -8.75393  1.000 26.40155 ? 544 ILE A CB  1 
ATOM   1274 C CG1 . ILE A 1 165 ? 15.62516 -7.12652  -7.64484  1.000 29.83438 ? 544 ILE A CG1 1 
ATOM   1275 C CG2 . ILE A 1 165 ? 15.66001 -9.57584  -8.18927  1.000 22.51605 ? 544 ILE A CG2 1 
ATOM   1276 C CD1 . ILE A 1 165 ? 16.67179 -7.22602  -6.55865  1.000 22.10981 ? 544 ILE A CD1 1 
ATOM   1277 N N   . TYR A 1 166 ? 16.79909 -8.74315  -11.74786 1.000 19.99235 ? 545 TYR A N   1 
ATOM   1278 C CA  . TYR A 1 166 ? 17.06591 -9.55126  -12.93641 1.000 21.29242 ? 545 TYR A CA  1 
ATOM   1279 C C   . TYR A 1 166 ? 18.56904 -9.69239  -13.17483 1.000 16.95885 ? 545 TYR A C   1 
ATOM   1280 O O   . TYR A 1 166 ? 19.10561 -10.80920 -13.29669 1.000 19.78870 ? 545 TYR A O   1 
ATOM   1281 C CB  . TYR A 1 166 ? 16.38053 -8.87699  -14.12975 1.000 21.01165 ? 545 TYR A CB  1 
ATOM   1282 C CG  . TYR A 1 166 ? 16.23008 -9.68578  -15.39678 1.000 26.20557 ? 545 TYR A CG  1 
ATOM   1283 C CD1 . TYR A 1 166 ? 16.51925 -11.04050 -15.43447 1.000 24.12818 ? 545 TYR A CD1 1 
ATOM   1284 C CD2 . TYR A 1 166 ? 15.79007 -9.07765  -16.56713 1.000 28.74205 ? 545 TYR A CD2 1 
ATOM   1285 C CE1 . TYR A 1 166 ? 16.37286 -11.76721 -16.60907 1.000 27.40757 ? 545 TYR A CE1 1 
ATOM   1286 C CE2 . TYR A 1 166 ? 15.64150 -9.79278  -17.73612 1.000 30.65965 ? 545 TYR A CE2 1 
ATOM   1287 C CZ  . TYR A 1 166 ? 15.93510 -11.13567 -17.75253 1.000 26.19573 ? 545 TYR A CZ  1 
ATOM   1288 O OH  . TYR A 1 166 ? 15.78811 -11.84732 -18.91824 1.000 26.22941 ? 545 TYR A OH  1 
ATOM   1289 N N   . THR A 1 167 ? 19.25614 -8.54748  -13.24260 1.000 21.55078 ? 546 THR A N   1 
ATOM   1290 C CA  . THR A 1 167 ? 20.70712 -8.49517  -13.38376 1.000 18.55660 ? 546 THR A CA  1 
ATOM   1291 C C   . THR A 1 167 ? 21.39696 -9.42592  -12.39745 1.000 19.06757 ? 546 THR A C   1 
ATOM   1292 O O   . THR A 1 167 ? 22.17250 -10.30540 -12.78752 1.000 15.85858 ? 546 THR A O   1 
ATOM   1293 C CB  . THR A 1 167 ? 21.19346 -7.05609  -13.17711 1.000 24.65900 ? 546 THR A CB  1 
ATOM   1294 O OG1 . THR A 1 167 ? 20.56036 -6.18256  -14.12401 1.000 19.46750 ? 546 THR A OG1 1 
ATOM   1295 C CG2 . THR A 1 167 ? 22.70528 -6.97825  -13.33840 1.000 16.52377 ? 546 THR A CG2 1 
ATOM   1296 N N   . LEU A 1 168 ? 21.11921 -9.23751  -11.10594 1.000 15.26632 ? 547 LEU A N   1 
ATOM   1297 C CA  . LEU A 1 168 ? 21.78115 -10.04078 -10.08386 1.000 18.94220 ? 547 LEU A CA  1 
ATOM   1298 C C   . LEU A 1 168 ? 21.46746 -11.52148 -10.24655 1.000 19.51001 ? 547 LEU A C   1 
ATOM   1299 O O   . LEU A 1 168 ? 22.35312 -12.37089 -10.08896 1.000 20.25073 ? 547 LEU A O   1 
ATOM   1300 C CB  . LEU A 1 168 ? 21.36801 -9.55741  -8.69760  1.000 20.31021 ? 547 LEU A CB  1 
ATOM   1301 C CG  . LEU A 1 168 ? 21.66937 -8.08766  -8.41422  1.000 22.81275 ? 547 LEU A CG  1 
ATOM   1302 C CD1 . LEU A 1 168 ? 20.98461 -7.65938  -7.13270  1.000 28.18611 ? 547 LEU A CD1 1 
ATOM   1303 C CD2 . LEU A 1 168 ? 23.17029 -7.86201  -8.33594  1.000 24.27696 ? 547 LEU A CD2 1 
ATOM   1304 N N   . LEU A 1 169 ? 20.21670 -11.85115 -10.57751 1.000 16.26740 ? 548 LEU A N   1 
ATOM   1305 C CA  . LEU A 1 169 ? 19.81565 -13.25010 -10.64001 1.000 18.35945 ? 548 LEU A CA  1 
ATOM   1306 C C   . LEU A 1 169 ? 20.49521 -13.99278 -11.78181 1.000 17.93855 ? 548 LEU A C   1 
ATOM   1307 O O   . LEU A 1 169 ? 20.69447 -15.20888 -11.68541 1.000 16.98744 ? 548 LEU A O   1 
ATOM   1308 C CB  . LEU A 1 169 ? 18.29654 -13.35775 -10.77162 1.000 18.41662 ? 548 LEU A CB  1 
ATOM   1309 C CG  . LEU A 1 169 ? 17.48617 -13.04558 -9.51002  1.000 18.87116 ? 548 LEU A CG  1 
ATOM   1310 C CD1 . LEU A 1 169 ? 15.99757 -13.04567 -9.81940  1.000 17.46683 ? 548 LEU A CD1 1 
ATOM   1311 C CD2 . LEU A 1 169 ? 17.80795 -14.04143 -8.40199  1.000 14.27379 ? 548 LEU A CD2 1 
ATOM   1312 N N   . PHE A 1 170 ? 20.85722 -13.30496 -12.86809 1.000 14.20384 ? 549 PHE A N   1 
ATOM   1313 C CA  . PHE A 1 170 ? 21.41173 -14.02012 -14.01598 1.000 15.96695 ? 549 PHE A CA  1 
ATOM   1314 C C   . PHE A 1 170 ? 22.90900 -13.79368 -14.22784 1.000 20.83403 ? 549 PHE A C   1 
ATOM   1315 O O   . PHE A 1 170 ? 23.41235 -14.02557 -15.33294 1.000 18.42641 ? 549 PHE A O   1 
ATOM   1316 C CB  . PHE A 1 170 ? 20.62720 -13.66552 -15.27572 1.000 15.63134 ? 549 PHE A CB  1 
ATOM   1317 C CG  . PHE A 1 170 ? 19.28759 -14.33177 -15.34082 1.000 16.55751 ? 549 PHE A CG  1 
ATOM   1318 C CD1 . PHE A 1 170 ? 18.21691 -13.82806 -14.62723 1.000 18.68406 ? 549 PHE A CD1 1 
ATOM   1319 C CD2 . PHE A 1 170 ? 19.10372 -15.47927 -16.09155 1.000 14.21708 ? 549 PHE A CD2 1 
ATOM   1320 C CE1 . PHE A 1 170 ? 16.98203 -14.44755 -14.67390 1.000 18.93581 ? 549 PHE A CE1 1 
ATOM   1321 C CE2 . PHE A 1 170 ? 17.86998 -16.09970 -16.14563 1.000 19.35213 ? 549 PHE A CE2 1 
ATOM   1322 C CZ  . PHE A 1 170 ? 16.80927 -15.58334 -15.43393 1.000 18.93669 ? 549 PHE A CZ  1 
ATOM   1323 N N   . LEU A 1 171 ? 23.64345 -13.39933 -13.18420 1.000 15.43716 ? 550 LEU A N   1 
ATOM   1324 C CA  . LEU A 1 171 ? 25.07740 -13.17367 -13.34670 1.000 17.54901 ? 550 LEU A CA  1 
ATOM   1325 C C   . LEU A 1 171 ? 25.83632 -14.47178 -13.59943 1.000 18.48725 ? 550 LEU A C   1 
ATOM   1326 O O   . LEU A 1 171 ? 26.89554 -14.45366 -14.23605 1.000 15.49725 ? 550 LEU A O   1 
ATOM   1327 C CB  . LEU A 1 171 ? 25.64633 -12.46581 -12.11536 1.000 16.09137 ? 550 LEU A CB  1 
ATOM   1328 C CG  . LEU A 1 171 ? 25.24209 -11.00569 -11.88538 1.000 15.15845 ? 550 LEU A CG  1 
ATOM   1329 C CD1 . LEU A 1 171 ? 25.76488 -10.51600 -10.54694 1.000 19.27396 ? 550 LEU A CD1 1 
ATOM   1330 C CD2 . LEU A 1 171 ? 25.75843 -10.11727 -13.01594 1.000 19.50823 ? 550 LEU A CD2 1 
ATOM   1331 N N   . GLN A 1 172 ? 25.32559 -15.60009 -13.10914 1.000 13.57933 ? 551 GLN A N   1 
ATOM   1332 C CA  . GLN A 1 172 ? 26.02520 -16.87548 -13.19373 1.000 19.22460 ? 551 GLN A CA  1 
ATOM   1333 C C   . GLN A 1 172 ? 25.46911 -17.78647 -14.28319 1.000 21.33230 ? 551 GLN A C   1 
ATOM   1334 O O   . GLN A 1 172 ? 25.86159 -18.95520 -14.36028 1.000 17.39424 ? 551 GLN A O   1 
ATOM   1335 C CB  . GLN A 1 172 ? 25.97367 -17.58845 -11.83931 1.000 14.29249 ? 551 GLN A CB  1 
ATOM   1336 C CG  . GLN A 1 172 ? 26.52636 -16.76109 -10.69044 1.000 20.37472 ? 551 GLN A CG  1 
ATOM   1337 C CD  . GLN A 1 172 ? 26.39216 -17.44594 -9.34254  1.000 28.63175 ? 551 GLN A CD  1 
ATOM   1338 O OE1 . GLN A 1 172 ? 25.38302 -17.29077 -8.65169  1.000 29.46624 ? 551 GLN A OE1 1 
ATOM   1339 N NE2 . GLN A 1 172 ? 27.41390 -18.20439 -8.95844  1.000 22.04083 ? 551 GLN A NE2 1 
ATOM   1340 N N   . SER A 1 173 ? 24.57828 -17.27760 -15.13217 1.000 19.48011 ? 552 SER A N   1 
ATOM   1341 C CA  . SER A 1 173 ? 23.85137 -18.09871 -16.10351 1.000 20.50903 ? 552 SER A CA  1 
ATOM   1342 C C   . SER A 1 173 ? 24.69584 -18.28636 -17.35926 1.000 20.55418 ? 552 SER A C   1 
ATOM   1343 O O   . SER A 1 173 ? 24.67066 -17.46992 -18.28148 1.000 17.11060 ? 552 SER A O   1 
ATOM   1344 C CB  . SER A 1 173 ? 22.51004 -17.45933 -16.43481 1.000 17.07325 ? 552 SER A CB  1 
ATOM   1345 O OG  . SER A 1 173 ? 21.69540 -17.36112 -15.28041 1.000 15.09432 ? 552 SER A OG  1 
ATOM   1346 N N   . THR A 1 174 ? 25.42669 -19.40345 -17.41026 1.000 17.34750 ? 553 THR A N   1 
ATOM   1347 C CA  . THR A 1 174 ? 26.39399 -19.65438 -18.47485 1.000 20.94521 ? 553 THR A CA  1 
ATOM   1348 C C   . THR A 1 174 ? 25.76134 -19.87703 -19.84402 1.000 21.20210 ? 553 THR A C   1 
ATOM   1349 O O   . THR A 1 174 ? 26.49958 -20.02918 -20.82380 1.000 21.61072 ? 553 THR A O   1 
ATOM   1350 C CB  . THR A 1 174 ? 27.25602 -20.86774 -18.12389 1.000 22.24209 ? 553 THR A CB  1 
ATOM   1351 O OG1 . THR A 1 174 ? 26.43985 -21.88009 -17.52115 1.000 25.90216 ? 553 THR A OG1 1 
ATOM   1352 C CG2 . THR A 1 174 ? 28.35384 -20.47896 -17.15869 1.000 20.04115 ? 553 THR A CG2 1 
ATOM   1353 N N   . HIS A 1 175 ? 24.43599 -19.91176 -19.94586 1.000 20.52360 ? 554 HIS A N   1 
ATOM   1354 C CA  . HIS A 1 175 ? 23.78416 -20.07264 -21.23828 1.000 22.81317 ? 554 HIS A CA  1 
ATOM   1355 C C   . HIS A 1 175 ? 23.37894 -18.74500 -21.86366 1.000 21.69488 ? 554 HIS A C   1 
ATOM   1356 O O   . HIS A 1 175 ? 22.89373 -18.73396 -23.00023 1.000 20.49951 ? 554 HIS A O   1 
ATOM   1357 C CB  . HIS A 1 175 ? 22.55754 -20.98035 -21.10220 1.000 19.79386 ? 554 HIS A CB  1 
ATOM   1358 C CG  . HIS A 1 175 ? 21.45009 -20.38338 -20.29075 1.000 20.18074 ? 554 HIS A CG  1 
ATOM   1359 N ND1 . HIS A 1 175 ? 21.49598 -20.29705 -18.91621 1.000 19.45235 ? 554 HIS A ND1 1 
ATOM   1360 C CD2 . HIS A 1 175 ? 20.26675 -19.83902 -20.66212 1.000 20.09853 ? 554 HIS A CD2 1 
ATOM   1361 C CE1 . HIS A 1 175 ? 20.38904 -19.72562 -18.47495 1.000 20.08937 ? 554 HIS A CE1 1 
ATOM   1362 N NE2 . HIS A 1 175 ? 19.62537 -19.44086 -19.51436 1.000 19.54517 ? 554 HIS A NE2 1 
ATOM   1363 N N   . LEU A 1 176 ? 23.57443 -17.63227 -21.15675 1.000 21.26713 ? 555 LEU A N   1 
ATOM   1364 C CA  . LEU A 1 176 ? 23.21543 -16.31461 -21.65937 1.000 19.25031 ? 555 LEU A CA  1 
ATOM   1365 C C   . LEU A 1 176 ? 24.47175 -15.54323 -22.03107 1.000 23.76307 ? 555 LEU A C   1 
ATOM   1366 O O   . LEU A 1 176 ? 25.37558 -15.39726 -21.19465 1.000 18.50875 ? 555 LEU A O   1 
ATOM   1367 C CB  . LEU A 1 176 ? 22.40262 -15.54371 -20.62204 1.000 20.72463 ? 555 LEU A CB  1 
ATOM   1368 C CG  . LEU A 1 176 ? 20.99134 -16.07151 -20.36251 1.000 28.80614 ? 555 LEU A CG  1 
ATOM   1369 C CD1 . LEU A 1 176 ? 20.30256 -15.22935 -19.30677 1.000 22.15129 ? 555 LEU A CD1 1 
ATOM   1370 C CD2 . LEU A 1 176 ? 20.18254 -16.08157 -21.65653 1.000 27.55599 ? 555 LEU A CD2 1 
ATOM   1371 N N   . PRO A 1 177 ? 24.56301 -15.03110 -23.25490 1.000 24.68472 ? 556 PRO A N   1 
ATOM   1372 C CA  . PRO A 1 177 ? 25.78137 -14.34252 -23.69120 1.000 23.03233 ? 556 PRO A CA  1 
ATOM   1373 C C   . PRO A 1 177 ? 25.95707 -13.02070 -22.95670 1.000 20.89243 ? 556 PRO A C   1 
ATOM   1374 O O   . PRO A 1 177 ? 24.99709 -12.42526 -22.46399 1.000 22.17899 ? 556 PRO A O   1 
ATOM   1375 C CB  . PRO A 1 177 ? 25.53941 -14.11933 -25.19267 1.000 29.84900 ? 556 PRO A CB  1 
ATOM   1376 C CG  . PRO A 1 177 ? 24.31323 -14.92766 -25.53723 1.000 32.12343 ? 556 PRO A CG  1 
ATOM   1377 C CD  . PRO A 1 177 ? 23.51492 -14.98810 -24.28232 1.000 30.04486 ? 556 PRO A CD  1 
ATOM   1378 N N   . TYR A 1 178 ? 27.20280 -12.54573 -22.89867 1.000 25.66406 ? 557 TYR A N   1 
ATOM   1379 C CA  . TYR A 1 178 ? 28.35556 -13.15975 -23.55754 1.000 24.33761 ? 557 TYR A CA  1 
ATOM   1380 C C   . TYR A 1 178 ? 29.41524 -13.58926 -22.55592 1.000 21.82969 ? 557 TYR A C   1 
ATOM   1381 O O   . TYR A 1 178 ? 30.29318 -14.38671 -22.87513 1.000 21.49533 ? 557 TYR A O   1 
ATOM   1382 C CB  . TYR A 1 178 ? 28.97177 -12.18618 -24.56714 1.000 24.91374 ? 557 TYR A CB  1 
ATOM   1383 C CG  . TYR A 1 178 ? 28.07947 -11.87748 -25.74603 1.000 30.76058 ? 557 TYR A CG  1 
ATOM   1384 C CD1 . TYR A 1 178 ? 27.13196 -10.86462 -25.67962 1.000 27.87367 ? 557 TYR A CD1 1 
ATOM   1385 C CD2 . TYR A 1 178 ? 28.18467 -12.60051 -26.92646 1.000 25.41507 ? 557 TYR A CD2 1 
ATOM   1386 C CE1 . TYR A 1 178 ? 26.31402 -10.58141 -26.75571 1.000 31.19184 ? 557 TYR A CE1 1 
ATOM   1387 C CE2 . TYR A 1 178 ? 27.37126 -12.32640 -28.00589 1.000 35.80209 ? 557 TYR A CE2 1 
ATOM   1388 C CZ  . TYR A 1 178 ? 26.43775 -11.31631 -27.91787 1.000 35.60894 ? 557 TYR A CZ  1 
ATOM   1389 O OH  . TYR A 1 178 ? 25.62778 -11.04655 -28.99885 1.000 37.29557 ? 557 TYR A OH  1 
ATOM   1390 N N   . ILE A 1 179 ? 29.34121 -13.04125 -21.34750 1.000 21.54786 ? 558 ILE A N   1 
ATOM   1391 C CA  . ILE A 1 179 ? 30.30474 -13.33876 -20.29617 1.000 19.08406 ? 558 ILE A CA  1 
ATOM   1392 C C   . ILE A 1 179 ? 29.55173 -13.46122 -18.98015 1.000 18.36317 ? 558 ILE A C   1 
ATOM   1393 O O   . ILE A 1 179 ? 28.60537 -12.71072 -18.71861 1.000 20.25672 ? 558 ILE A O   1 
ATOM   1394 C CB  . ILE A 1 179 ? 31.41270 -12.26412 -20.22282 1.000 16.80128 ? 558 ILE A CB  1 
ATOM   1395 C CG1 . ILE A 1 179 ? 32.48373 -12.65072 -19.19895 1.000 18.30137 ? 558 ILE A CG1 1 
ATOM   1396 C CG2 . ILE A 1 179 ? 30.82350 -10.89358 -19.90716 1.000 18.84318 ? 558 ILE A CG2 1 
ATOM   1397 C CD1 . ILE A 1 179 ? 33.66108 -11.69824 -19.15528 1.000 16.75476 ? 558 ILE A CD1 1 
ATOM   1398 N N   . ARG A 1 180 ? 29.95613 -14.42917 -18.16288 1.000 17.60397 ? 559 ARG A N   1 
ATOM   1399 C CA  . ARG A 1 180 ? 29.27922 -14.69598 -16.90136 1.000 16.12261 ? 559 ARG A CA  1 
ATOM   1400 C C   . ARG A 1 180 ? 30.31280 -14.85429 -15.79510 1.000 23.51507 ? 559 ARG A C   1 
ATOM   1401 O O   . ARG A 1 180 ? 31.51220 -14.96748 -16.04685 1.000 21.31629 ? 559 ARG A O   1 
ATOM   1402 C CB  . ARG A 1 180 ? 28.38927 -15.94215 -16.99747 1.000 17.74438 ? 559 ARG A CB  1 
ATOM   1403 C CG  . ARG A 1 180 ? 27.26399 -15.80869 -18.01331 1.000 20.33280 ? 559 ARG A CG  1 
ATOM   1404 C CD  . ARG A 1 180 ? 26.24470 -14.76936 -17.56428 1.000 18.51221 ? 559 ARG A CD  1 
ATOM   1405 N NE  . ARG A 1 180 ? 25.52929 -14.18094 -18.68964 1.000 17.46998 ? 559 ARG A NE  1 
ATOM   1406 C CZ  . ARG A 1 180 ? 24.65781 -13.18840 -18.57784 1.000 20.19162 ? 559 ARG A CZ  1 
ATOM   1407 N NH1 . ARG A 1 180 ? 24.35264 -12.66636 -17.40213 1.000 13.46281 ? 559 ARG A NH1 1 
ATOM   1408 N NH2 . ARG A 1 180 ? 24.08360 -12.70161 -19.67317 1.000 18.19607 ? 559 ARG A NH2 1 
ATOM   1409 N N   . ILE A 1 181 ? 29.83625 -14.84764 -14.55415 1.000 19.46437 ? 560 ILE A N   1 
ATOM   1410 C CA  . ILE A 1 181 ? 30.67364 -15.07473 -13.38005 1.000 21.31523 ? 560 ILE A CA  1 
ATOM   1411 C C   . ILE A 1 181 ? 30.28221 -16.42185 -12.79085 1.000 22.08184 ? 560 ILE A C   1 
ATOM   1412 O O   . ILE A 1 181 ? 29.14227 -16.60204 -12.34705 1.000 24.95656 ? 560 ILE A O   1 
ATOM   1413 C CB  . ILE A 1 181 ? 30.52238 -13.95338 -12.33982 1.000 20.97213 ? 560 ILE A CB  1 
ATOM   1414 C CG1 . ILE A 1 181 ? 30.96571 -12.60924 -12.92364 1.000 22.98012 ? 560 ILE A CG1 1 
ATOM   1415 C CG2 . ILE A 1 181 ? 31.31762 -14.28285 -11.08201 1.000 25.36977 ? 560 ILE A CG2 1 
ATOM   1416 C CD1 . ILE A 1 181 ? 29.81281 -11.70158 -13.29294 1.000 26.60497 ? 560 ILE A CD1 1 
ATOM   1417 N N   . THR A 1 182 ? 31.22110 -17.37109 -12.78484 1.000 20.24679 ? 561 THR A N   1 
ATOM   1418 C CA  . THR A 1 182 ? 30.95358 -18.73737 -12.36155 1.000 21.88414 ? 561 THR A CA  1 
ATOM   1419 C C   . THR A 1 182 ? 31.89183 -19.12336 -11.22266 1.000 26.34985 ? 561 THR A C   1 
ATOM   1420 O O   . THR A 1 182 ? 32.87820 -18.41754 -10.96947 1.000 20.80503 ? 561 THR A O   1 
ATOM   1421 C CB  . THR A 1 182 ? 31.12962 -19.69498 -13.54207 1.000 22.95181 ? 561 THR A CB  1 
ATOM   1422 O OG1 . THR A 1 182 ? 32.52727 -19.90134 -13.77988 1.000 22.74772 ? 561 THR A OG1 1 
ATOM   1423 C CG2 . THR A 1 182 ? 30.50146 -19.10699 -14.79458 1.000 25.92103 ? 561 THR A CG2 1 
ATOM   1424 N N   . PRO A 1 183 ? 31.62254 -20.23834 -10.51107 1.000 23.34747 ? 562 PRO A N   1 
ATOM   1425 C CA  . PRO A 1 183 ? 32.55868 -20.70521 -9.47517  1.000 24.32756 ? 562 PRO A CA  1 
ATOM   1426 C C   . PRO A 1 183 ? 33.99036 -20.88737 -9.96319  1.000 26.67205 ? 562 PRO A C   1 
ATOM   1427 O O   . PRO A 1 183 ? 34.92402 -20.90935 -9.15446  1.000 26.78707 ? 562 PRO A O   1 
ATOM   1428 C CB  . PRO A 1 183 ? 31.94894 -22.04367 -9.04194  1.000 27.92119 ? 562 PRO A CB  1 
ATOM   1429 C CG  . PRO A 1 183 ? 30.48902 -21.86513 -9.26185  1.000 28.55385 ? 562 PRO A CG  1 
ATOM   1430 C CD  . PRO A 1 183 ? 30.34067 -20.96899 -10.46406 1.000 21.92788 ? 562 PRO A CD  1 
ATOM   1431 N N   . ARG A 1 184 ? 34.18016 -21.01280 -11.27534 1.000 25.15912 ? 563 ARG A N   1 
ATOM   1432 C CA  . ARG A 1 184 ? 35.50074 -21.21711 -11.85296 1.000 24.57084 ? 563 ARG A CA  1 
ATOM   1433 C C   . ARG A 1 184 ? 36.14731 -19.92935 -12.35035 1.000 31.62524 ? 563 ARG A C   1 
ATOM   1434 O O   . ARG A 1 184 ? 37.28629 -19.97192 -12.82411 1.000 31.43886 ? 563 ARG A O   1 
ATOM   1435 C CB  . ARG A 1 184 ? 35.42075 -22.23066 -12.99890 1.000 31.63926 ? 563 ARG A CB  1 
ATOM   1436 N N   . GLY A 1 185 ? 35.45772 -18.79149 -12.25475 1.000 22.55797 ? 564 GLY A N   1 
ATOM   1437 C CA  . GLY A 1 185 ? 35.95714 -17.49852 -12.67375 1.000 25.62007 ? 564 GLY A CA  1 
ATOM   1438 C C   . GLY A 1 185 ? 35.01858 -16.85844 -13.67177 1.000 25.15296 ? 564 GLY A C   1 
ATOM   1439 O O   . GLY A 1 185 ? 33.87534 -17.28665 -13.85370 1.000 21.75769 ? 564 GLY A O   1 
ATOM   1440 N N   . ILE A 1 186 ? 35.48664 -15.79254 -14.32384 1.000 20.90058 ? 565 ILE A N   1 
ATOM   1441 C CA  . ILE A 1 186 ? 34.70833 -15.23196 -15.41989 1.000 20.94136 ? 565 ILE A CA  1 
ATOM   1442 C C   . ILE A 1 186 ? 34.77231 -16.18652 -16.60648 1.000 24.14389 ? 565 ILE A C   1 
ATOM   1443 O O   . ILE A 1 186 ? 35.77517 -16.87778 -16.83033 1.000 20.90261 ? 565 ILE A O   1 
ATOM   1444 C CB  . ILE A 1 186 ? 35.18819 -13.82123 -15.80543 1.000 26.35552 ? 565 ILE A CB  1 
ATOM   1445 C CG1 . ILE A 1 186 ? 36.70194 -13.80335 -16.01258 1.000 29.35660 ? 565 ILE A CG1 1 
ATOM   1446 C CG2 . ILE A 1 186 ? 34.75275 -12.80573 -14.75668 1.000 25.10693 ? 565 ILE A CG2 1 
ATOM   1447 C CD1 . ILE A 1 186 ? 37.20168 -12.54351 -16.68177 1.000 30.51159 ? 565 ILE A CD1 1 
ATOM   1448 N N   . PHE A 1 187 ? 33.69006 -16.22256 -17.37738 1.000 21.43994 ? 566 PHE A N   1 
ATOM   1449 C CA  . PHE A 1 187 ? 33.43289 -17.31291 -18.30770 1.000 22.32137 ? 566 PHE A CA  1 
ATOM   1450 C C   . PHE A 1 187 ? 32.94388 -16.74451 -19.62973 1.000 25.64612 ? 566 PHE A C   1 
ATOM   1451 O O   . PHE A 1 187 ? 31.93953 -16.02384 -19.66206 1.000 22.15235 ? 566 PHE A O   1 
ATOM   1452 C CB  . PHE A 1 187 ? 32.40012 -18.27367 -17.71255 1.000 21.33169 ? 566 PHE A CB  1 
ATOM   1453 C CG  . PHE A 1 187 ? 32.16032 -19.50037 -18.53495 1.000 24.69198 ? 566 PHE A CG  1 
ATOM   1454 C CD1 . PHE A 1 187 ? 33.03095 -20.57377 -18.47102 1.000 24.11263 ? 566 PHE A CD1 1 
ATOM   1455 C CD2 . PHE A 1 187 ? 31.05245 -19.59002 -19.35726 1.000 28.16866 ? 566 PHE A CD2 1 
ATOM   1456 C CE1 . PHE A 1 187 ? 32.80876 -21.70703 -19.22349 1.000 25.70050 ? 566 PHE A CE1 1 
ATOM   1457 C CE2 . PHE A 1 187 ? 30.82413 -20.72319 -20.10974 1.000 27.07741 ? 566 PHE A CE2 1 
ATOM   1458 C CZ  . PHE A 1 187 ? 31.70401 -21.78273 -20.04155 1.000 28.35494 ? 566 PHE A CZ  1 
ATOM   1459 N N   . ASP A 1 188 ? 33.66188 -17.06728 -20.70654 1.000 27.45318 ? 567 ASP A N   1 
ATOM   1460 C CA  . ASP A 1 188 ? 33.26636 -16.71609 -22.06745 1.000 25.91851 ? 567 ASP A CA  1 
ATOM   1461 C C   . ASP A 1 188 ? 32.15813 -17.66827 -22.50035 1.000 25.46738 ? 567 ASP A C   1 
ATOM   1462 O O   . ASP A 1 188 ? 32.39044 -18.87020 -22.65394 1.000 25.95867 ? 567 ASP A O   1 
ATOM   1463 C CB  . ASP A 1 188 ? 34.47394 -16.79954 -23.00026 1.000 25.42307 ? 567 ASP A CB  1 
ATOM   1464 C CG  . ASP A 1 188 ? 34.19218 -16.25571 -24.39453 1.000 31.25437 ? 567 ASP A CG  1 
ATOM   1465 O OD1 . ASP A 1 188 ? 33.10053 -16.51303 -24.94402 1.000 26.81219 ? 567 ASP A OD1 1 
ATOM   1466 O OD2 . ASP A 1 188 ? 35.07970 -15.57413 -24.94930 1.000 35.80766 ? 567 ASP A OD2 1 
ATOM   1467 N N   . VAL A 1 189 ? 30.95283 -17.13463 -22.70481 1.000 23.96276 ? 568 VAL A N   1 
ATOM   1468 C CA  . VAL A 1 189 ? 29.80218 -17.99063 -22.98159 1.000 22.86843 ? 568 VAL A CA  1 
ATOM   1469 C C   . VAL A 1 189 ? 29.88635 -18.58341 -24.38498 1.000 32.65722 ? 568 VAL A C   1 
ATOM   1470 O O   . VAL A 1 189 ? 29.56528 -19.76013 -24.59631 1.000 28.54115 ? 568 VAL A O   1 
ATOM   1471 C CB  . VAL A 1 189 ? 28.49451 -17.20494 -22.76906 1.000 25.24764 ? 568 VAL A CB  1 
ATOM   1472 C CG1 . VAL A 1 189 ? 27.31086 -17.96714 -23.34599 1.000 24.72882 ? 568 VAL A CG1 1 
ATOM   1473 C CG2 . VAL A 1 189 ? 28.27982 -16.93140 -21.28483 1.000 24.22599 ? 568 VAL A CG2 1 
ATOM   1474 N N   . MET A 1 190 ? 30.32108 -17.78923 -25.36594 1.000 29.74867 ? 569 MET A N   1 
ATOM   1475 C CA  . MET A 1 190 ? 30.34194 -18.27211 -26.74379 1.000 34.23351 ? 569 MET A CA  1 
ATOM   1476 C C   . MET A 1 190 ? 31.43011 -19.32141 -26.94345 1.000 35.14578 ? 569 MET A C   1 
ATOM   1477 O O   . MET A 1 190 ? 31.18576 -20.37680 -27.53869 1.000 34.43500 ? 569 MET A O   1 
ATOM   1478 C CB  . MET A 1 190 ? 30.52771 -17.10346 -27.71476 1.000 33.45994 ? 569 MET A CB  1 
ATOM   1479 C CG  . MET A 1 190 ? 29.46948 -16.01619 -27.57753 1.000 41.40312 ? 569 MET A CG  1 
ATOM   1480 S SD  . MET A 1 190 ? 27.79512 -16.67420 -27.41224 1.000 49.14957 ? 569 MET A SD  1 
ATOM   1481 C CE  . MET A 1 190 ? 27.20454 -16.58766 -29.10271 1.000 48.77592 ? 569 MET A CE  1 
ATOM   1482 N N   . LYS A 1 191 ? 32.63963 -19.05211 -26.45236 1.000 33.14851 ? 570 LYS A N   1 
ATOM   1483 C CA  . LYS A 1 191 ? 33.73609 -20.00381 -26.56999 1.000 29.84425 ? 570 LYS A CA  1 
ATOM   1484 C C   . LYS A 1 191 ? 33.73096 -21.05072 -25.46285 1.000 34.37751 ? 570 LYS A C   1 
ATOM   1485 O O   . LYS A 1 191 ? 34.54028 -21.98316 -25.51198 1.000 39.75402 ? 570 LYS A O   1 
ATOM   1486 C CB  . LYS A 1 191 ? 35.07766 -19.26270 -26.57869 1.000 31.58879 ? 570 LYS A CB  1 
ATOM   1487 C CG  . LYS A 1 191 ? 35.04459 -17.95388 -27.35594 1.000 37.81210 ? 570 LYS A CG  1 
ATOM   1488 C CD  . LYS A 1 191 ? 36.35326 -17.69734 -28.09158 1.000 43.12223 ? 570 LYS A CD  1 
ATOM   1489 C CE  . LYS A 1 191 ? 37.54601 -17.69769 -27.15418 1.000 50.01183 ? 570 LYS A CE  1 
ATOM   1490 N NZ  . LYS A 1 191 ? 37.56543 -16.51411 -26.25195 1.000 46.33403 ? 570 LYS A NZ  1 
ATOM   1491 N N   . LYS A 1 192 ? 32.84566 -20.91227 -24.47422 1.000 30.32416 ? 571 LYS A N   1 
ATOM   1492 C CA  . LYS A 1 192 ? 32.66416 -21.89346 -23.40142 1.000 29.48798 ? 571 LYS A CA  1 
ATOM   1493 C C   . LYS A 1 192 ? 33.98374 -22.23061 -22.70912 1.000 31.75470 ? 571 LYS A C   1 
ATOM   1494 O O   . LYS A 1 192 ? 34.31726 -23.39503 -22.47896 1.000 34.64728 ? 571 LYS A O   1 
ATOM   1495 C CB  . LYS A 1 192 ? 31.97793 -23.15586 -23.92685 1.000 39.25021 ? 571 LYS A CB  1 
ATOM   1496 C CG  . LYS A 1 192 ? 30.48946 -22.97209 -24.18064 1.000 37.07559 ? 571 LYS A CG  1 
ATOM   1497 C CD  . LYS A 1 192 ? 29.75236 -24.29838 -24.24516 1.000 50.17758 ? 571 LYS A CD  1 
ATOM   1498 C CE  . LYS A 1 192 ? 29.61166 -24.80076 -25.67187 1.000 60.73357 ? 571 LYS A CE  1 
ATOM   1499 N NZ  . LYS A 1 192 ? 28.86802 -26.09250 -25.70819 1.000 66.51248 ? 571 LYS A NZ  1 
ATOM   1500 N N   . THR A 1 193 ? 34.73904 -21.18960 -22.36636 1.000 25.29309 ? 572 THR A N   1 
ATOM   1501 C CA  . THR A 1 193 ? 36.00817 -21.35993 -21.67739 1.000 26.66433 ? 572 THR A CA  1 
ATOM   1502 C C   . THR A 1 193 ? 36.11584 -20.35211 -20.54380 1.000 29.28604 ? 572 THR A C   1 
ATOM   1503 O O   . THR A 1 193 ? 35.62628 -19.22399 -20.64500 1.000 25.06591 ? 572 THR A O   1 
ATOM   1504 C CB  . THR A 1 193 ? 37.20758 -21.19587 -22.62547 1.000 28.59351 ? 572 THR A CB  1 
ATOM   1505 O OG1 . THR A 1 193 ? 38.42142 -21.21110 -21.86428 1.000 37.49826 ? 572 THR A OG1 1 
ATOM   1506 C CG2 . THR A 1 193 ? 37.11795 -19.88371 -23.38972 1.000 34.65227 ? 572 THR A CG2 1 
ATOM   1507 N N   . VAL A 1 194 ? 36.75584 -20.77987 -19.45316 1.000 26.95270 ? 573 VAL A N   1 
ATOM   1508 C CA  . VAL A 1 194 ? 37.11269 -19.84937 -18.39176 1.000 25.52974 ? 573 VAL A CA  1 
ATOM   1509 C C   . VAL A 1 194 ? 38.12911 -18.84890 -18.92127 1.000 26.17669 ? 573 VAL A C   1 
ATOM   1510 O O   . VAL A 1 194 ? 39.10050 -19.21569 -19.59483 1.000 32.50715 ? 573 VAL A O   1 
ATOM   1511 C CB  . VAL A 1 194 ? 37.66995 -20.60766 -17.17552 1.000 25.46595 ? 573 VAL A CB  1 
ATOM   1512 C CG1 . VAL A 1 194 ? 38.26914 -19.63421 -16.16251 1.000 21.55520 ? 573 VAL A CG1 1 
ATOM   1513 C CG2 . VAL A 1 194 ? 36.58781 -21.45765 -16.53569 1.000 20.11894 ? 573 VAL A CG2 1 
ATOM   1514 N N   . LEU A 1 195 ? 37.90315 -17.57008 -18.62703 1.000 23.60285 ? 574 LEU A N   1 
ATOM   1515 C CA  . LEU A 1 195 ? 38.86728 -16.53963 -18.98843 1.000 23.38404 ? 574 LEU A CA  1 
ATOM   1516 C C   . LEU A 1 195 ? 39.87355 -16.38293 -17.85669 1.000 30.59132 ? 574 LEU A C   1 
ATOM   1517 O O   . LEU A 1 195 ? 40.81270 -17.17742 -17.74558 1.000 28.85156 ? 574 LEU A O   1 
ATOM   1518 C CB  . LEU A 1 195 ? 38.15528 -15.22172 -19.29624 1.000 28.19510 ? 574 LEU A CB  1 
ATOM   1519 C CG  . LEU A 1 195 ? 37.17367 -15.32970 -20.46623 1.000 29.88249 ? 574 LEU A CG  1 
ATOM   1520 C CD1 . LEU A 1 195 ? 36.23783 -14.13864 -20.50972 1.000 31.90529 ? 574 LEU A CD1 1 
ATOM   1521 C CD2 . LEU A 1 195 ? 37.92424 -15.46650 -21.78233 1.000 31.25600 ? 574 LEU A CD2 1 
ATOM   1522 N N   . PHE A 1 196 ? 39.68460 -15.37857 -17.00645 1.000 30.45618 ? 575 PHE A N   1 
ATOM   1523 C CA  . PHE A 1 196 ? 40.52011 -15.30702 -15.81203 1.000 28.91590 ? 575 PHE A CA  1 
ATOM   1524 C C   . PHE A 1 196 ? 39.84540 -16.05865 -14.66993 1.000 30.31240 ? 575 PHE A C   1 
ATOM   1525 O O   . PHE A 1 196 ? 38.64547 -15.86788 -14.43380 1.000 29.53941 ? 575 PHE A O   1 
ATOM   1526 C CB  . PHE A 1 196 ? 40.78144 -13.86062 -15.41676 1.000 30.06695 ? 575 PHE A CB  1 
ATOM   1527 C CG  . PHE A 1 196 ? 41.60532 -13.10640 -16.41972 1.000 32.06861 ? 575 PHE A CG  1 
ATOM   1528 C CD1 . PHE A 1 196 ? 41.00008 -12.44411 -17.47409 1.000 27.30908 ? 575 PHE A CD1 1 
ATOM   1529 C CD2 . PHE A 1 196 ? 42.98621 -13.07526 -16.31915 1.000 28.57940 ? 575 PHE A CD2 1 
ATOM   1530 C CE1 . PHE A 1 196 ? 41.75342 -11.75769 -18.40269 1.000 29.72457 ? 575 PHE A CE1 1 
ATOM   1531 C CE2 . PHE A 1 196 ? 43.74713 -12.38846 -17.24765 1.000 29.16287 ? 575 PHE A CE2 1 
ATOM   1532 C CZ  . PHE A 1 196 ? 43.12834 -11.73096 -18.29191 1.000 28.34471 ? 575 PHE A CZ  1 
ATOM   1533 N N   . PRO A 1 197 ? 40.57308 -16.90198 -13.94416 1.000 29.32493 ? 576 PRO A N   1 
ATOM   1534 C CA  . PRO A 1 197 ? 39.93222 -17.87054 -13.05216 1.000 28.18963 ? 576 PRO A CA  1 
ATOM   1535 C C   . PRO A 1 197 ? 39.52879 -17.26155 -11.71506 1.000 31.05900 ? 576 PRO A C   1 
ATOM   1536 O O   . PRO A 1 197 ? 39.85059 -16.11912 -11.38325 1.000 24.67658 ? 576 PRO A O   1 
ATOM   1537 C CB  . PRO A 1 197 ? 41.01965 -18.92925 -12.85816 1.000 31.80845 ? 576 PRO A CB  1 
ATOM   1538 C CG  . PRO A 1 197 ? 42.28242 -18.14194 -12.93277 1.000 28.46688 ? 576 PRO A CG  1 
ATOM   1539 C CD  . PRO A 1 197 ? 42.03857 -17.05506 -13.95717 1.000 37.00454 ? 576 PRO A CD  1 
ATOM   1540 N N   . SER A 1 198 ? 38.80624 -18.07001 -10.94450 1.000 29.46234 ? 577 SER A N   1 
ATOM   1541 C CA  . SER A 1 198 ? 38.41744 -17.69012 -9.59837  1.000 28.57857 ? 577 SER A CA  1 
ATOM   1542 C C   . SER A 1 198 ? 39.58030 -17.90774 -8.63274  1.000 31.10819 ? 577 SER A C   1 
ATOM   1543 O O   . SER A 1 198 ? 40.61371 -18.48881 -8.97667  1.000 31.88096 ? 577 SER A O   1 
ATOM   1544 C CB  . SER A 1 198 ? 37.19606 -18.48970 -9.14968  1.000 22.70144 ? 577 SER A CB  1 
ATOM   1545 O OG  . SER A 1 198 ? 37.47655 -19.87900 -9.11976  1.000 26.05919 ? 577 SER A OG  1 
ATOM   1546 N N   . ILE A 1 199 ? 39.40175 -17.42956 -7.40497  1.000 25.83370 ? 578 ILE A N   1 
ATOM   1547 C CA  . ILE A 1 199 ? 40.41325 -17.52868 -6.36042  1.000 29.46628 ? 578 ILE A CA  1 
ATOM   1548 C C   . ILE A 1 199 ? 39.89726 -18.46088 -5.27507  1.000 31.14617 ? 578 ILE A C   1 
ATOM   1549 O O   . ILE A 1 199 ? 38.74438 -18.34143 -4.84278  1.000 30.49470 ? 578 ILE A O   1 
ATOM   1550 C CB  . ILE A 1 199 ? 40.75486 -16.14575 -5.77929  1.000 31.57056 ? 578 ILE A CB  1 
ATOM   1551 C CG1 . ILE A 1 199 ? 41.29199 -15.22029 -6.87141  1.000 37.02851 ? 578 ILE A CG1 1 
ATOM   1552 C CG2 . ILE A 1 199 ? 41.75732 -16.27428 -4.64260  1.000 37.78349 ? 578 ILE A CG2 1 
ATOM   1553 C CD1 . ILE A 1 199 ? 42.75545 -15.43153 -7.19786  1.000 43.74804 ? 578 ILE A CD1 1 
ATOM   1554 N N   . MET A 1 200 ? 40.74145 -19.39704 -4.84724  1.000 29.59892 ? 579 MET A N   1 
ATOM   1555 C CA  . MET A 1 200 ? 40.44578 -20.20797 -3.67377  1.000 31.19869 ? 579 MET A CA  1 
ATOM   1556 C C   . MET A 1 200 ? 40.75497 -19.39305 -2.42317  1.000 33.66682 ? 579 MET A C   1 
ATOM   1557 O O   . MET A 1 200 ? 41.90394 -18.99191 -2.20526  1.000 35.94357 ? 579 MET A O   1 
ATOM   1558 C CB  . MET A 1 200 ? 41.25386 -21.50303 -3.69664  1.000 31.00971 ? 579 MET A CB  1 
ATOM   1559 C CG  . MET A 1 200 ? 40.91916 -22.41523 -4.86311  1.000 37.16426 ? 579 MET A CG  1 
ATOM   1560 S SD  . MET A 1 200 ? 39.16974 -22.85267 -4.90226  1.000 41.08084 ? 579 MET A SD  1 
ATOM   1561 C CE  . MET A 1 200 ? 38.77789 -22.54058 -6.62279  1.000 40.97668 ? 579 MET A CE  1 
ATOM   1562 N N   . ARG A 1 201 ? 39.73297 -19.14457 -1.60919  1.000 28.58363 ? 580 ARG A N   1 
ATOM   1563 C CA  . ARG A 1 201 ? 39.86781 -18.27787 -0.44165  1.000 31.73836 ? 580 ARG A CA  1 
ATOM   1564 C C   . ARG A 1 201 ? 40.76392 -18.89843 0.62559   1.000 36.41438 ? 580 ARG A C   1 
ATOM   1565 O O   . ARG A 1 201 ? 40.95167 -20.11306 0.67610   1.000 34.86275 ? 580 ARG A O   1 
ATOM   1566 C CB  . ARG A 1 201 ? 38.48893 -17.95855 0.14862   1.000 29.29563 ? 580 ARG A CB  1 
ATOM   1567 C CG  . ARG A 1 201 ? 37.55676 -17.23850 -0.81826  1.000 28.44679 ? 580 ARG A CG  1 
ATOM   1568 C CD  . ARG A 1 201 ? 36.21844 -16.88648 -0.17553  1.000 24.72208 ? 580 ARG A CD  1 
ATOM   1569 N NE  . ARG A 1 201 ? 36.35305 -15.88537 0.87668   1.000 24.86712 ? 580 ARG A NE  1 
ATOM   1570 C CZ  . ARG A 1 201 ? 36.31845 -16.15336 2.17521   1.000 33.88339 ? 580 ARG A CZ  1 
ATOM   1571 N NH1 . ARG A 1 201 ? 36.14567 -17.38599 2.62306   1.000 31.03760 ? 580 ARG A NH1 1 
ATOM   1572 N NH2 . ARG A 1 201 ? 36.46011 -15.15949 3.04714   1.000 33.67672 ? 580 ARG A NH2 1 
ATOM   1573 O OXT . ARG A 1 201 ? 41.31802 -18.19210 1.46601   1.000 34.49666 ? 580 ARG A OXT 1 
HETATM 1574 O O   . HOH B 2 .   ? 2.60041  -17.14737 -1.98596  1.000 33.14096 ? 601 HOH A O   1 
HETATM 1575 O O   . HOH B 2 .   ? 31.07529 -15.10956 -25.01815 1.000 33.79598 ? 602 HOH A O   1 
HETATM 1576 O O   . HOH B 2 .   ? 28.06976 -22.07039 -3.78493  1.000 36.00778 ? 603 HOH A O   1 
HETATM 1577 O O   . HOH B 2 .   ? 39.45025 -21.88487 -0.08180  1.000 35.75478 ? 604 HOH A O   1 
HETATM 1578 O O   . HOH B 2 .   ? 36.63369 3.81219   2.93783   1.000 32.31057 ? 605 HOH A O   1 
HETATM 1579 O O   . HOH B 2 .   ? 32.13870 -24.65970 -2.60938  1.000 29.71758 ? 606 HOH A O   1 
HETATM 1580 O O   . HOH B 2 .   ? 25.99514 -12.29707 -31.13621 1.000 30.96386 ? 607 HOH A O   1 
HETATM 1581 O O   . HOH B 2 .   ? 27.33866 -21.85047 -7.36473  1.000 27.36364 ? 608 HOH A O   1 
HETATM 1582 O O   . HOH B 2 .   ? 8.11348  -11.98031 -6.02120  1.000 31.96383 ? 609 HOH A O   1 
HETATM 1583 O O   . HOH B 2 .   ? 28.29478 9.95937   -10.35528 1.000 31.21789 ? 610 HOH A O   1 
HETATM 1584 O O   . HOH B 2 .   ? 23.37374 2.01626   -15.55723 1.000 27.77876 ? 611 HOH A O   1 
HETATM 1585 O O   . HOH B 2 .   ? 20.11018 5.99502   -13.15931 1.000 37.89790 ? 612 HOH A O   1 
HETATM 1586 O O   . HOH B 2 .   ? 44.35965 -3.50671  -9.12258  1.000 31.04746 ? 613 HOH A O   1 
HETATM 1587 O O   . HOH B 2 .   ? 19.56018 -10.46545 -5.86671  1.000 27.54913 ? 614 HOH A O   1 
HETATM 1588 O O   . HOH B 2 .   ? 40.81554 -10.16897 -9.86448  1.000 25.69701 ? 615 HOH A O   1 
HETATM 1589 O O   . HOH B 2 .   ? 35.20483 7.28333   0.70685   1.000 28.83649 ? 616 HOH A O   1 
HETATM 1590 O O   . HOH B 2 .   ? 33.34882 -1.79945  6.80372   1.000 33.54384 ? 617 HOH A O   1 
HETATM 1591 O O   . HOH B 2 .   ? 17.015   -19.063   -20.011   1.000 31.31356 ? 618 HOH A O   1 
HETATM 1592 O O   . HOH B 2 .   ? 41.82022 -3.81212  -5.30598  1.000 25.75701 ? 619 HOH A O   1 
HETATM 1593 O O   . HOH B 2 .   ? 14.00282 -13.07600 5.72193   1.000 30.15959 ? 620 HOH A O   1 
HETATM 1594 O O   . HOH B 2 .   ? 25.84388 8.59232   -10.05164 1.000 33.87711 ? 621 HOH A O   1 
HETATM 1595 O O   . HOH B 2 .   ? 42.45875 -3.56596  -18.09596 1.000 22.59637 ? 622 HOH A O   1 
HETATM 1596 O O   . HOH B 2 .   ? 41.63543 -11.76430 -5.94410  1.000 38.43002 ? 623 HOH A O   1 
HETATM 1597 O O   . HOH B 2 .   ? 29.19989 -0.24210  -12.39297 1.000 19.87970 ? 624 HOH A O   1 
HETATM 1598 O O   . HOH B 2 .   ? 16.42499 -12.67037 6.19929   1.000 32.25089 ? 625 HOH A O   1 
HETATM 1599 O O   . HOH B 2 .   ? 26.50751 7.51064   -3.13018  1.000 33.03912 ? 626 HOH A O   1 
HETATM 1600 O O   . HOH B 2 .   ? 37.94897 -0.74400  -22.32026 1.000 35.12258 ? 627 HOH A O   1 
HETATM 1601 O O   . HOH B 2 .   ? 13.40715 4.34015   -9.67551  1.000 45.20666 ? 628 HOH A O   1 
HETATM 1602 O O   . HOH B 2 .   ? 39.69742 -6.84825  -11.52107 1.000 25.78360 ? 629 HOH A O   1 
HETATM 1603 O O   . HOH B 2 .   ? 33.48980 -0.23912  -23.01534 1.000 33.90100 ? 630 HOH A O   1 
HETATM 1604 O O   . HOH B 2 .   ? 28.34402 -8.23426  12.40756  1.000 40.80253 ? 631 HOH A O   1 
HETATM 1605 O O   . HOH B 2 .   ? 26.65820 -0.13240  -19.83577 1.000 30.35973 ? 632 HOH A O   1 
HETATM 1606 O O   . HOH B 2 .   ? 22.72378 -16.89747 -12.42137 1.000 18.89284 ? 633 HOH A O   1 
HETATM 1607 O O   . HOH B 2 .   ? 35.92997 -13.00149 -24.50061 1.000 40.77289 ? 634 HOH A O   1 
HETATM 1608 O O   . HOH B 2 .   ? 14.09015 -11.04963 -20.93083 1.000 27.90583 ? 635 HOH A O   1 
HETATM 1609 O O   . HOH B 2 .   ? 42.33917 -1.16465  -1.68950  1.000 26.88822 ? 636 HOH A O   1 
HETATM 1610 O O   . HOH B 2 .   ? 23.34516 -21.24144 -17.06847 1.000 27.34473 ? 637 HOH A O   1 
HETATM 1611 O O   . HOH B 2 .   ? 41.97767 -14.37101 -11.79188 1.000 28.07393 ? 638 HOH A O   1 
HETATM 1612 O O   . HOH B 2 .   ? 32.06799 -8.11476  6.22327   1.000 27.93767 ? 639 HOH A O   1 
HETATM 1613 O O   . HOH B 2 .   ? 21.09393 -16.41775 -9.19909  1.000 19.39869 ? 640 HOH A O   1 
HETATM 1614 O O   . HOH B 2 .   ? 47.47428 1.35477   -5.07518  1.000 44.00434 ? 641 HOH A O   1 
HETATM 1615 O O   . HOH B 2 .   ? 43.37938 -19.84761 -5.65814  1.000 35.33897 ? 642 HOH A O   1 
HETATM 1616 O O   . HOH B 2 .   ? 23.73377 8.27363   2.61016   1.000 39.64172 ? 643 HOH A O   1 
HETATM 1617 O O   . HOH B 2 .   ? 28.86107 1.41827   -19.80174 1.000 26.09728 ? 644 HOH A O   1 
HETATM 1618 O O   . HOH B 2 .   ? 32.92760 -4.13049  -24.03357 1.000 31.15467 ? 645 HOH A O   1 
HETATM 1619 O O   . HOH B 2 .   ? 29.23857 -16.01615 10.29448  1.000 47.75361 ? 646 HOH A O   1 
HETATM 1620 O O   . HOH B 2 .   ? 23.10719 -10.69854 -15.41322 1.000 18.75580 ? 647 HOH A O   1 
HETATM 1621 O O   . HOH B 2 .   ? 25.88942 4.59492   -14.42481 1.000 29.60641 ? 648 HOH A O   1 
HETATM 1622 O O   . HOH B 2 .   ? 45.27471 6.09597   -9.68028  1.000 26.10091 ? 649 HOH A O   1 
HETATM 1623 O O   . HOH B 2 .   ? 25.45205 3.29715   -1.95536  1.000 25.13727 ? 650 HOH A O   1 
HETATM 1624 O O   . HOH B 2 .   ? 37.14440 -2.89505  -23.55427 1.000 30.05151 ? 651 HOH A O   1 
HETATM 1625 O O   . HOH B 2 .   ? 45.13727 -2.49601  -3.81353  1.000 42.83081 ? 652 HOH A O   1 
HETATM 1626 O O   . HOH B 2 .   ? 38.34433 5.36662   -9.98502  1.000 23.26351 ? 653 HOH A O   1 
HETATM 1627 O O   . HOH B 2 .   ? 26.26615 3.88926   -16.92472 1.000 28.56675 ? 654 HOH A O   1 
HETATM 1628 O O   . HOH B 2 .   ? 28.80913 2.24210   -7.99750  1.000 21.79908 ? 655 HOH A O   1 
HETATM 1629 O O   . HOH B 2 .   ? 31.94180 -24.29122 4.21510   1.000 39.89431 ? 656 HOH A O   1 
HETATM 1630 O O   . HOH B 2 .   ? 23.18476 2.43890   9.56909   1.000 37.62887 ? 657 HOH A O   1 
HETATM 1631 O O   . HOH B 2 .   ? 27.87988 -20.42345 -12.95763 1.000 21.42889 ? 658 HOH A O   1 
HETATM 1632 O O   . HOH B 2 .   ? 30.24926 -11.03512 9.70115   1.000 38.51125 ? 659 HOH A O   1 
HETATM 1633 O O   . HOH B 2 .   ? 37.08313 -23.65129 -19.59659 1.000 39.64895 ? 660 HOH A O   1 
HETATM 1634 O O   . HOH B 2 .   ? 23.38737 -15.05649 -9.76881  1.000 27.97082 ? 661 HOH A O   1 
HETATM 1635 O O   . HOH B 2 .   ? 32.07351 5.79253   -17.39882 1.000 36.44285 ? 662 HOH A O   1 
HETATM 1636 O O   . HOH B 2 .   ? 38.99031 -13.64604 -9.25465  1.000 25.82576 ? 663 HOH A O   1 
HETATM 1637 O O   . HOH B 2 .   ? 20.43312 -16.34451 1.84798   1.000 19.97343 ? 664 HOH A O   1 
HETATM 1638 O O   . HOH B 2 .   ? 37.92573 8.44588   -13.44310 1.000 39.01035 ? 665 HOH A O   1 
HETATM 1639 O O   . HOH B 2 .   ? 15.48662 -0.84322  4.92619   1.000 32.48537 ? 666 HOH A O   1 
HETATM 1640 O O   . HOH B 2 .   ? 27.90763 -10.27087 10.29051  1.000 29.88156 ? 667 HOH A O   1 
HETATM 1641 O O   . HOH B 2 .   ? 19.19876 8.78793   -1.36602  1.000 43.72466 ? 668 HOH A O   1 
HETATM 1642 O O   . HOH B 2 .   ? 9.11900  -9.26412  -7.21903  1.000 44.17788 ? 669 HOH A O   1 
HETATM 1643 O O   . HOH B 2 .   ? 41.850   5.471     -12.667   1.000 33.23900 ? 670 HOH A O   1 
HETATM 1644 O O   . HOH B 2 .   ? 12.34244 -0.10635  4.05862   1.000 42.17929 ? 671 HOH A O   1 
HETATM 1645 O O   . HOH B 2 .   ? 38.83693 -6.59235  6.70929   1.000 32.40707 ? 672 HOH A O   1 
HETATM 1646 O O   . HOH B 2 .   ? 16.39834 2.52427   -13.63908 1.000 35.70655 ? 673 HOH A O   1 
HETATM 1647 O O   . HOH B 2 .   ? 40.73882 4.75294   -8.80998  1.000 37.16922 ? 674 HOH A O   1 
HETATM 1648 O O   . HOH B 2 .   ? 31.47756 -10.46673 7.46443   1.000 34.49064 ? 675 HOH A O   1 
HETATM 1649 O O   . HOH B 2 .   ? 20.42014 2.90876   9.19061   1.000 30.17609 ? 676 HOH A O   1 
HETATM 1650 O O   . HOH B 2 .   ? 43.71460 -4.98624  -5.12234  1.000 41.62625 ? 677 HOH A O   1 
HETATM 1651 O O   . HOH B 2 .   ? 29.48948 7.26822   9.30610   1.000 39.84358 ? 678 HOH A O   1 
HETATM 1652 O O   . HOH B 2 .   ? 28.36956 9.04979   -1.41428  1.000 41.86421 ? 679 HOH A O   1 
HETATM 1653 O O   . HOH B 2 .   ? 11.88568 -9.92668  -7.75974  1.000 44.45773 ? 680 HOH A O   1 
HETATM 1654 O O   . HOH B 2 .   ? 24.47162 2.62424   -17.99858 1.000 33.70126 ? 681 HOH A O   1 
HETATM 1655 O O   . HOH B 2 .   ? 25.58062 10.88154  -6.92870  1.000 48.70658 ? 682 HOH A O   1 
HETATM 1656 O O   . HOH B 2 .   ? 24.12420 -8.63263  -15.85877 1.000 31.54310 ? 683 HOH A O   1 
HETATM 1657 O O   . HOH B 2 .   ? 23.30670 11.57442  -7.68416  1.000 51.49601 ? 684 HOH A O   1 
HETATM 1658 O O   . HOH B 2 .   ? 17.72076 1.78341   7.31552   1.000 35.27058 ? 685 HOH A O   1 
HETATM 1659 O O   . HOH B 2 .   ? 41.48585 -12.48900 -8.48391  1.000 33.40363 ? 686 HOH A O   1 
HETATM 1660 O O   . HOH B 2 .   ? 32.88839 -5.93198  8.41872   1.000 43.44040 ? 687 HOH A O   1 
HETATM 1661 O O   . HOH B 2 .   ? 39.21175 7.41609   -11.72598 1.000 34.40846 ? 688 HOH A O   1 
HETATM 1662 O O   . HOH B 2 .   ? 32.45675 0.51554   7.70235   1.000 37.63532 ? 689 HOH A O   1 
HETATM 1663 O O   . HOH B 2 .   ? 18.95761 -0.02195  8.53978   1.000 41.22024 ? 690 HOH A O   1 
HETATM 1664 O O   . HOH B 2 .   ? 34.42429 -2.12749  -24.19254 1.000 37.19634 ? 691 HOH A O   1 
HETATM 1665 O O   . HOH B 2 .   ? 45.28428 6.01059   -12.27196 1.000 43.44887 ? 692 HOH A O   1 
HETATM 1666 O O   . HOH B 2 .   ? 42.808   6.698     -10.022   1.000 32.15062 ? 693 HOH A O   1 
HETATM 1667 O O   . HOH B 2 .   ? 12.185   -11.432   -13.149   1.000 34.31809 ? 694 HOH A O   1 
HETATM 1668 O O   . HOH B 2 .   ? 28.70759 -22.81532 -13.89768 1.000 34.07210 ? 695 HOH A O   1 
HETATM 1669 O O   . HOH B 2 .   ? 30.36902 -6.08600  11.79879  1.000 46.86109 ? 696 HOH A O   1 
HETATM 1670 O O   . HOH B 2 .   ? 47.681   7.132     -9.029    1.000 28.41997 ? 697 HOH A O   1 
HETATM 1671 O O   . HOH B 2 .   ? 31.32627 -4.43491  9.94563   1.000 45.42952 ? 699 HOH A O   1 
HETATM 1672 O O   . HOH B 2 .   ? 42.67329 -10.07923 -21.05543 1.000 33.74273 ? 700 HOH A O   1 
# 
