data_9JQI
# 
_entry.id   9JQI 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.398 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9JQI         pdb_00009jqi 10.2210/pdb9jqi/pdb 
WWPDB D_1300051953 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-11-06 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9JQI 
_pdbx_database_status.recvd_initial_deposition_date   2024-09-27 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              njlxc1901@163.com 
_pdbx_contact_author.name_first         Xichun 
_pdbx_contact_author.name_last          Liu 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-2860-8205 
# 
_audit_author.name               'Liu, X.C.' 
_audit_author.pdbx_ordinal       1 
_audit_author.identifier_ORCID   ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Crystal structure of calmodulin in complex with KN93 (1:1 complex)' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
_citation_author.citation_id        primary 
_citation_author.name               'Liu, X.C.' 
_citation_author.ordinal            1 
_citation_author.identifier_ORCID   ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man Calmodulin-1 17898.125 3  ? ? ? ? 
2 non-polymer syn 'CALCIUM ION' 40.078    12 ? ? ? ? 
3 non-polymer syn 
"N-[2-[[[3-(4'-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4'-methoxybenzenesulfonamide" 501.037   3  ? 
? ? ? 
4 water       nat water 18.015    91 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   yes 
_entity_poly.pdbx_seq_one_letter_code       
;GPH(MSE)ADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTV(MSE)RSLGQNPTEAELQD(MSE)INEVDADGNGTID
FPEFLT(MSE)(MSE)ARK(MSE)KDTDSEEEIREAFRVFDKDGNGYISAAELRHV(MSE)TNLGEKLTDEEVDE(MSE)
IREADIDGDGQVNYEEFVQ(MSE)(MSE)TAKNGL
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GPHMADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKM
KDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAKNGL
;
_entity_poly.pdbx_strand_id                 A,B,C 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'CALCIUM ION'                                                                                                       CA  
3 "N-[2-[[[3-(4'-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4'-methoxybenzenesulfonamide" KN9 
4 water                                                                                                               HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   PRO n 
1 3   HIS n 
1 4   MSE n 
1 5   ALA n 
1 6   ASP n 
1 7   GLN n 
1 8   LEU n 
1 9   THR n 
1 10  GLU n 
1 11  GLU n 
1 12  GLN n 
1 13  ILE n 
1 14  ALA n 
1 15  GLU n 
1 16  PHE n 
1 17  LYS n 
1 18  GLU n 
1 19  ALA n 
1 20  PHE n 
1 21  SER n 
1 22  LEU n 
1 23  PHE n 
1 24  ASP n 
1 25  LYS n 
1 26  ASP n 
1 27  GLY n 
1 28  ASP n 
1 29  GLY n 
1 30  THR n 
1 31  ILE n 
1 32  THR n 
1 33  THR n 
1 34  LYS n 
1 35  GLU n 
1 36  LEU n 
1 37  GLY n 
1 38  THR n 
1 39  VAL n 
1 40  MSE n 
1 41  ARG n 
1 42  SER n 
1 43  LEU n 
1 44  GLY n 
1 45  GLN n 
1 46  ASN n 
1 47  PRO n 
1 48  THR n 
1 49  GLU n 
1 50  ALA n 
1 51  GLU n 
1 52  LEU n 
1 53  GLN n 
1 54  ASP n 
1 55  MSE n 
1 56  ILE n 
1 57  ASN n 
1 58  GLU n 
1 59  VAL n 
1 60  ASP n 
1 61  ALA n 
1 62  ASP n 
1 63  GLY n 
1 64  ASN n 
1 65  GLY n 
1 66  THR n 
1 67  ILE n 
1 68  ASP n 
1 69  PHE n 
1 70  PRO n 
1 71  GLU n 
1 72  PHE n 
1 73  LEU n 
1 74  THR n 
1 75  MSE n 
1 76  MSE n 
1 77  ALA n 
1 78  ARG n 
1 79  LYS n 
1 80  MSE n 
1 81  LYS n 
1 82  ASP n 
1 83  THR n 
1 84  ASP n 
1 85  SER n 
1 86  GLU n 
1 87  GLU n 
1 88  GLU n 
1 89  ILE n 
1 90  ARG n 
1 91  GLU n 
1 92  ALA n 
1 93  PHE n 
1 94  ARG n 
1 95  VAL n 
1 96  PHE n 
1 97  ASP n 
1 98  LYS n 
1 99  ASP n 
1 100 GLY n 
1 101 ASN n 
1 102 GLY n 
1 103 TYR n 
1 104 ILE n 
1 105 SER n 
1 106 ALA n 
1 107 ALA n 
1 108 GLU n 
1 109 LEU n 
1 110 ARG n 
1 111 HIS n 
1 112 VAL n 
1 113 MSE n 
1 114 THR n 
1 115 ASN n 
1 116 LEU n 
1 117 GLY n 
1 118 GLU n 
1 119 LYS n 
1 120 LEU n 
1 121 THR n 
1 122 ASP n 
1 123 GLU n 
1 124 GLU n 
1 125 VAL n 
1 126 ASP n 
1 127 GLU n 
1 128 MSE n 
1 129 ILE n 
1 130 ARG n 
1 131 GLU n 
1 132 ALA n 
1 133 ASP n 
1 134 ILE n 
1 135 ASP n 
1 136 GLY n 
1 137 ASP n 
1 138 GLY n 
1 139 GLN n 
1 140 VAL n 
1 141 ASN n 
1 142 TYR n 
1 143 GLU n 
1 144 GLU n 
1 145 PHE n 
1 146 VAL n 
1 147 GLN n 
1 148 MSE n 
1 149 MSE n 
1 150 THR n 
1 151 ALA n 
1 152 LYS n 
1 153 ASN n 
1 154 GLY n 
1 155 LEU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   155 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'CALM1, CALM, CAM, CAM1' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2'         89.093  
ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1'     175.209 
ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'        132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'         133.103 
CA  non-polymer         . 'CALCIUM ION' ? 'Ca 2'               40.078  
GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'       146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'         147.129 
GLY 'peptide linking'   y GLYCINE ? 'C2 H5 N O2'         75.067  
HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1'     156.162 
HOH non-polymer         . WATER ? 'H2 O'               18.015  
ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'        131.173 
KN9 non-polymer         . 
"N-[2-[[[3-(4'-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4'-methoxybenzenesulfonamide" 
'N-[2-({[(2E)-3-(4-chlorophenyl)prop-2-en-1-yl](methyl)amino}methyl)phenyl]-N-(2-hydroxyethyl)-4-methoxybenzene-1-sulfonamide' 
'C26 H29 Cl N2 O4 S' 501.037 
LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'        131.173 
LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1'     147.195 
MSE 'L-peptide linking' n SELENOMETHIONINE ? 'C5 H11 N O2 Se'     196.106 
PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'        165.189 
PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2'         115.130 
SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3'         105.093 
THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3'         119.119 
TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'        181.189 
VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2'        117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   -3  ?   ?   ?   A . n 
A 1 2   PRO 2   -2  ?   ?   ?   A . n 
A 1 3   HIS 3   -1  ?   ?   ?   A . n 
A 1 4   MSE 4   0   ?   ?   ?   A . n 
A 1 5   ALA 5   1   ?   ?   ?   A . n 
A 1 6   ASP 6   2   ?   ?   ?   A . n 
A 1 7   GLN 7   3   ?   ?   ?   A . n 
A 1 8   LEU 8   4   4   LEU LEU A . n 
A 1 9   THR 9   5   5   THR THR A . n 
A 1 10  GLU 10  6   6   GLU GLU A . n 
A 1 11  GLU 11  7   7   GLU GLU A . n 
A 1 12  GLN 12  8   8   GLN GLN A . n 
A 1 13  ILE 13  9   9   ILE ILE A . n 
A 1 14  ALA 14  10  10  ALA ALA A . n 
A 1 15  GLU 15  11  11  GLU GLU A . n 
A 1 16  PHE 16  12  12  PHE PHE A . n 
A 1 17  LYS 17  13  13  LYS LYS A . n 
A 1 18  GLU 18  14  14  GLU GLU A . n 
A 1 19  ALA 19  15  15  ALA ALA A . n 
A 1 20  PHE 20  16  16  PHE PHE A . n 
A 1 21  SER 21  17  17  SER SER A . n 
A 1 22  LEU 22  18  18  LEU LEU A . n 
A 1 23  PHE 23  19  19  PHE PHE A . n 
A 1 24  ASP 24  20  20  ASP ASP A . n 
A 1 25  LYS 25  21  21  LYS LYS A . n 
A 1 26  ASP 26  22  22  ASP ASP A . n 
A 1 27  GLY 27  23  23  GLY GLY A . n 
A 1 28  ASP 28  24  24  ASP ASP A . n 
A 1 29  GLY 29  25  25  GLY GLY A . n 
A 1 30  THR 30  26  26  THR THR A . n 
A 1 31  ILE 31  27  27  ILE ILE A . n 
A 1 32  THR 32  28  28  THR THR A . n 
A 1 33  THR 33  29  29  THR THR A . n 
A 1 34  LYS 34  30  30  LYS LYS A . n 
A 1 35  GLU 35  31  31  GLU GLU A . n 
A 1 36  LEU 36  32  32  LEU LEU A . n 
A 1 37  GLY 37  33  33  GLY GLY A . n 
A 1 38  THR 38  34  34  THR THR A . n 
A 1 39  VAL 39  35  35  VAL VAL A . n 
A 1 40  MSE 40  36  36  MSE MSE A . n 
A 1 41  ARG 41  37  37  ARG ARG A . n 
A 1 42  SER 42  38  38  SER SER A . n 
A 1 43  LEU 43  39  39  LEU LEU A . n 
A 1 44  GLY 44  40  40  GLY GLY A . n 
A 1 45  GLN 45  41  41  GLN GLN A . n 
A 1 46  ASN 46  42  42  ASN ASN A . n 
A 1 47  PRO 47  43  43  PRO PRO A . n 
A 1 48  THR 48  44  44  THR THR A . n 
A 1 49  GLU 49  45  45  GLU GLU A . n 
A 1 50  ALA 50  46  46  ALA ALA A . n 
A 1 51  GLU 51  47  47  GLU GLU A . n 
A 1 52  LEU 52  48  48  LEU LEU A . n 
A 1 53  GLN 53  49  49  GLN GLN A . n 
A 1 54  ASP 54  50  50  ASP ASP A . n 
A 1 55  MSE 55  51  51  MSE MSE A . n 
A 1 56  ILE 56  52  52  ILE ILE A . n 
A 1 57  ASN 57  53  53  ASN ASN A . n 
A 1 58  GLU 58  54  54  GLU GLU A . n 
A 1 59  VAL 59  55  55  VAL VAL A . n 
A 1 60  ASP 60  56  56  ASP ASP A . n 
A 1 61  ALA 61  57  57  ALA ALA A . n 
A 1 62  ASP 62  58  58  ASP ASP A . n 
A 1 63  GLY 63  59  59  GLY GLY A . n 
A 1 64  ASN 64  60  60  ASN ASN A . n 
A 1 65  GLY 65  61  61  GLY GLY A . n 
A 1 66  THR 66  62  62  THR THR A . n 
A 1 67  ILE 67  63  63  ILE ILE A . n 
A 1 68  ASP 68  64  64  ASP ASP A . n 
A 1 69  PHE 69  65  65  PHE PHE A . n 
A 1 70  PRO 70  66  66  PRO PRO A . n 
A 1 71  GLU 71  67  67  GLU GLU A . n 
A 1 72  PHE 72  68  68  PHE PHE A . n 
A 1 73  LEU 73  69  69  LEU LEU A . n 
A 1 74  THR 74  70  70  THR THR A . n 
A 1 75  MSE 75  71  71  MSE MSE A . n 
A 1 76  MSE 76  72  72  MSE MSE A . n 
A 1 77  ALA 77  73  73  ALA ALA A . n 
A 1 78  ARG 78  74  74  ARG ARG A . n 
A 1 79  LYS 79  75  75  LYS LYS A . n 
A 1 80  MSE 80  76  76  MSE MSE A . n 
A 1 81  LYS 81  77  ?   ?   ?   A . n 
A 1 82  ASP 82  78  ?   ?   ?   A . n 
A 1 83  THR 83  79  79  THR THR A . n 
A 1 84  ASP 84  80  80  ASP ASP A . n 
A 1 85  SER 85  81  81  SER SER A . n 
A 1 86  GLU 86  82  82  GLU GLU A . n 
A 1 87  GLU 87  83  83  GLU GLU A . n 
A 1 88  GLU 88  84  84  GLU GLU A . n 
A 1 89  ILE 89  85  85  ILE ILE A . n 
A 1 90  ARG 90  86  86  ARG ARG A . n 
A 1 91  GLU 91  87  87  GLU GLU A . n 
A 1 92  ALA 92  88  88  ALA ALA A . n 
A 1 93  PHE 93  89  89  PHE PHE A . n 
A 1 94  ARG 94  90  90  ARG ARG A . n 
A 1 95  VAL 95  91  91  VAL VAL A . n 
A 1 96  PHE 96  92  92  PHE PHE A . n 
A 1 97  ASP 97  93  93  ASP ASP A . n 
A 1 98  LYS 98  94  94  LYS LYS A . n 
A 1 99  ASP 99  95  95  ASP ASP A . n 
A 1 100 GLY 100 96  96  GLY GLY A . n 
A 1 101 ASN 101 97  97  ASN ASN A . n 
A 1 102 GLY 102 98  98  GLY GLY A . n 
A 1 103 TYR 103 99  99  TYR TYR A . n 
A 1 104 ILE 104 100 100 ILE ILE A . n 
A 1 105 SER 105 101 101 SER SER A . n 
A 1 106 ALA 106 102 102 ALA ALA A . n 
A 1 107 ALA 107 103 103 ALA ALA A . n 
A 1 108 GLU 108 104 104 GLU GLU A . n 
A 1 109 LEU 109 105 105 LEU LEU A . n 
A 1 110 ARG 110 106 106 ARG ARG A . n 
A 1 111 HIS 111 107 107 HIS HIS A . n 
A 1 112 VAL 112 108 108 VAL VAL A . n 
A 1 113 MSE 113 109 109 MSE MSE A . n 
A 1 114 THR 114 110 110 THR THR A . n 
A 1 115 ASN 115 111 111 ASN ASN A . n 
A 1 116 LEU 116 112 112 LEU LEU A . n 
A 1 117 GLY 117 113 113 GLY GLY A . n 
A 1 118 GLU 118 114 114 GLU GLU A . n 
A 1 119 LYS 119 115 115 LYS LYS A . n 
A 1 120 LEU 120 116 116 LEU LEU A . n 
A 1 121 THR 121 117 117 THR THR A . n 
A 1 122 ASP 122 118 118 ASP ASP A . n 
A 1 123 GLU 123 119 119 GLU GLU A . n 
A 1 124 GLU 124 120 120 GLU GLU A . n 
A 1 125 VAL 125 121 121 VAL VAL A . n 
A 1 126 ASP 126 122 122 ASP ASP A . n 
A 1 127 GLU 127 123 123 GLU GLU A . n 
A 1 128 MSE 128 124 124 MSE MSE A . n 
A 1 129 ILE 129 125 125 ILE ILE A . n 
A 1 130 ARG 130 126 126 ARG ARG A . n 
A 1 131 GLU 131 127 127 GLU GLU A . n 
A 1 132 ALA 132 128 128 ALA ALA A . n 
A 1 133 ASP 133 129 129 ASP ASP A . n 
A 1 134 ILE 134 130 130 ILE ILE A . n 
A 1 135 ASP 135 131 131 ASP ASP A . n 
A 1 136 GLY 136 132 132 GLY GLY A . n 
A 1 137 ASP 137 133 133 ASP ASP A . n 
A 1 138 GLY 138 134 134 GLY GLY A . n 
A 1 139 GLN 139 135 135 GLN GLN A . n 
A 1 140 VAL 140 136 136 VAL VAL A . n 
A 1 141 ASN 141 137 137 ASN ASN A . n 
A 1 142 TYR 142 138 138 TYR TYR A . n 
A 1 143 GLU 143 139 139 GLU GLU A . n 
A 1 144 GLU 144 140 140 GLU GLU A . n 
A 1 145 PHE 145 141 141 PHE PHE A . n 
A 1 146 VAL 146 142 142 VAL VAL A . n 
A 1 147 GLN 147 143 143 GLN GLN A . n 
A 1 148 MSE 148 144 144 MSE MSE A . n 
A 1 149 MSE 149 145 145 MSE MSE A . n 
A 1 150 THR 150 146 146 THR THR A . n 
A 1 151 ALA 151 147 147 ALA ALA A . n 
A 1 152 LYS 152 148 148 LYS LYS A . n 
A 1 153 ASN 153 149 149 ASN ASN A . n 
A 1 154 GLY 154 150 ?   ?   ?   A . n 
A 1 155 LEU 155 151 ?   ?   ?   A . n 
B 1 1   GLY 1   -3  ?   ?   ?   B . n 
B 1 2   PRO 2   -2  ?   ?   ?   B . n 
B 1 3   HIS 3   -1  ?   ?   ?   B . n 
B 1 4   MSE 4   0   ?   ?   ?   B . n 
B 1 5   ALA 5   1   ?   ?   ?   B . n 
B 1 6   ASP 6   2   ?   ?   ?   B . n 
B 1 7   GLN 7   3   ?   ?   ?   B . n 
B 1 8   LEU 8   4   ?   ?   ?   B . n 
B 1 9   THR 9   5   5   THR THR B . n 
B 1 10  GLU 10  6   6   GLU GLU B . n 
B 1 11  GLU 11  7   7   GLU GLU B . n 
B 1 12  GLN 12  8   8   GLN GLN B . n 
B 1 13  ILE 13  9   9   ILE ILE B . n 
B 1 14  ALA 14  10  10  ALA ALA B . n 
B 1 15  GLU 15  11  11  GLU GLU B . n 
B 1 16  PHE 16  12  12  PHE PHE B . n 
B 1 17  LYS 17  13  13  LYS LYS B . n 
B 1 18  GLU 18  14  14  GLU GLU B . n 
B 1 19  ALA 19  15  15  ALA ALA B . n 
B 1 20  PHE 20  16  16  PHE PHE B . n 
B 1 21  SER 21  17  17  SER SER B . n 
B 1 22  LEU 22  18  18  LEU LEU B . n 
B 1 23  PHE 23  19  19  PHE PHE B . n 
B 1 24  ASP 24  20  20  ASP ASP B . n 
B 1 25  LYS 25  21  21  LYS LYS B . n 
B 1 26  ASP 26  22  22  ASP ASP B . n 
B 1 27  GLY 27  23  23  GLY GLY B . n 
B 1 28  ASP 28  24  24  ASP ASP B . n 
B 1 29  GLY 29  25  25  GLY GLY B . n 
B 1 30  THR 30  26  26  THR THR B . n 
B 1 31  ILE 31  27  27  ILE ILE B . n 
B 1 32  THR 32  28  28  THR THR B . n 
B 1 33  THR 33  29  29  THR THR B . n 
B 1 34  LYS 34  30  30  LYS LYS B . n 
B 1 35  GLU 35  31  31  GLU GLU B . n 
B 1 36  LEU 36  32  32  LEU LEU B . n 
B 1 37  GLY 37  33  33  GLY GLY B . n 
B 1 38  THR 38  34  34  THR THR B . n 
B 1 39  VAL 39  35  35  VAL VAL B . n 
B 1 40  MSE 40  36  36  MSE MSE B . n 
B 1 41  ARG 41  37  37  ARG ARG B . n 
B 1 42  SER 42  38  38  SER SER B . n 
B 1 43  LEU 43  39  39  LEU LEU B . n 
B 1 44  GLY 44  40  40  GLY GLY B . n 
B 1 45  GLN 45  41  41  GLN GLN B . n 
B 1 46  ASN 46  42  42  ASN ASN B . n 
B 1 47  PRO 47  43  43  PRO PRO B . n 
B 1 48  THR 48  44  44  THR THR B . n 
B 1 49  GLU 49  45  45  GLU GLU B . n 
B 1 50  ALA 50  46  46  ALA ALA B . n 
B 1 51  GLU 51  47  47  GLU GLU B . n 
B 1 52  LEU 52  48  48  LEU LEU B . n 
B 1 53  GLN 53  49  49  GLN GLN B . n 
B 1 54  ASP 54  50  50  ASP ASP B . n 
B 1 55  MSE 55  51  51  MSE MSE B . n 
B 1 56  ILE 56  52  52  ILE ILE B . n 
B 1 57  ASN 57  53  53  ASN ASN B . n 
B 1 58  GLU 58  54  54  GLU GLU B . n 
B 1 59  VAL 59  55  55  VAL VAL B . n 
B 1 60  ASP 60  56  56  ASP ASP B . n 
B 1 61  ALA 61  57  57  ALA ALA B . n 
B 1 62  ASP 62  58  58  ASP ASP B . n 
B 1 63  GLY 63  59  59  GLY GLY B . n 
B 1 64  ASN 64  60  60  ASN ASN B . n 
B 1 65  GLY 65  61  61  GLY GLY B . n 
B 1 66  THR 66  62  62  THR THR B . n 
B 1 67  ILE 67  63  63  ILE ILE B . n 
B 1 68  ASP 68  64  64  ASP ASP B . n 
B 1 69  PHE 69  65  65  PHE PHE B . n 
B 1 70  PRO 70  66  66  PRO PRO B . n 
B 1 71  GLU 71  67  67  GLU GLU B . n 
B 1 72  PHE 72  68  68  PHE PHE B . n 
B 1 73  LEU 73  69  69  LEU LEU B . n 
B 1 74  THR 74  70  70  THR THR B . n 
B 1 75  MSE 75  71  71  MSE MSE B . n 
B 1 76  MSE 76  72  72  MSE MSE B . n 
B 1 77  ALA 77  73  73  ALA ALA B . n 
B 1 78  ARG 78  74  74  ARG ARG B . n 
B 1 79  LYS 79  75  75  LYS LYS B . n 
B 1 80  MSE 80  76  ?   ?   ?   B . n 
B 1 81  LYS 81  77  ?   ?   ?   B . n 
B 1 82  ASP 82  78  ?   ?   ?   B . n 
B 1 83  THR 83  79  ?   ?   ?   B . n 
B 1 84  ASP 84  80  ?   ?   ?   B . n 
B 1 85  SER 85  81  81  SER SER B . n 
B 1 86  GLU 86  82  82  GLU GLU B . n 
B 1 87  GLU 87  83  83  GLU GLU B . n 
B 1 88  GLU 88  84  84  GLU GLU B . n 
B 1 89  ILE 89  85  85  ILE ILE B . n 
B 1 90  ARG 90  86  86  ARG ARG B . n 
B 1 91  GLU 91  87  87  GLU GLU B . n 
B 1 92  ALA 92  88  88  ALA ALA B . n 
B 1 93  PHE 93  89  89  PHE PHE B . n 
B 1 94  ARG 94  90  90  ARG ARG B . n 
B 1 95  VAL 95  91  91  VAL VAL B . n 
B 1 96  PHE 96  92  92  PHE PHE B . n 
B 1 97  ASP 97  93  93  ASP ASP B . n 
B 1 98  LYS 98  94  94  LYS LYS B . n 
B 1 99  ASP 99  95  95  ASP ASP B . n 
B 1 100 GLY 100 96  96  GLY GLY B . n 
B 1 101 ASN 101 97  97  ASN ASN B . n 
B 1 102 GLY 102 98  98  GLY GLY B . n 
B 1 103 TYR 103 99  99  TYR TYR B . n 
B 1 104 ILE 104 100 100 ILE ILE B . n 
B 1 105 SER 105 101 101 SER SER B . n 
B 1 106 ALA 106 102 102 ALA ALA B . n 
B 1 107 ALA 107 103 103 ALA ALA B . n 
B 1 108 GLU 108 104 104 GLU GLU B . n 
B 1 109 LEU 109 105 105 LEU LEU B . n 
B 1 110 ARG 110 106 106 ARG ARG B . n 
B 1 111 HIS 111 107 107 HIS HIS B . n 
B 1 112 VAL 112 108 108 VAL VAL B . n 
B 1 113 MSE 113 109 109 MSE MSE B . n 
B 1 114 THR 114 110 110 THR THR B . n 
B 1 115 ASN 115 111 111 ASN ASN B . n 
B 1 116 LEU 116 112 112 LEU LEU B . n 
B 1 117 GLY 117 113 113 GLY GLY B . n 
B 1 118 GLU 118 114 114 GLU GLU B . n 
B 1 119 LYS 119 115 115 LYS LYS B . n 
B 1 120 LEU 120 116 116 LEU LEU B . n 
B 1 121 THR 121 117 117 THR THR B . n 
B 1 122 ASP 122 118 118 ASP ASP B . n 
B 1 123 GLU 123 119 119 GLU GLU B . n 
B 1 124 GLU 124 120 120 GLU GLU B . n 
B 1 125 VAL 125 121 121 VAL VAL B . n 
B 1 126 ASP 126 122 122 ASP ASP B . n 
B 1 127 GLU 127 123 123 GLU GLU B . n 
B 1 128 MSE 128 124 124 MSE MSE B . n 
B 1 129 ILE 129 125 125 ILE ILE B . n 
B 1 130 ARG 130 126 126 ARG ARG B . n 
B 1 131 GLU 131 127 127 GLU GLU B . n 
B 1 132 ALA 132 128 128 ALA ALA B . n 
B 1 133 ASP 133 129 129 ASP ASP B . n 
B 1 134 ILE 134 130 130 ILE ILE B . n 
B 1 135 ASP 135 131 131 ASP ASP B . n 
B 1 136 GLY 136 132 132 GLY GLY B . n 
B 1 137 ASP 137 133 133 ASP ASP B . n 
B 1 138 GLY 138 134 134 GLY GLY B . n 
B 1 139 GLN 139 135 135 GLN GLN B . n 
B 1 140 VAL 140 136 136 VAL VAL B . n 
B 1 141 ASN 141 137 137 ASN ASN B . n 
B 1 142 TYR 142 138 138 TYR TYR B . n 
B 1 143 GLU 143 139 139 GLU GLU B . n 
B 1 144 GLU 144 140 140 GLU GLU B . n 
B 1 145 PHE 145 141 141 PHE PHE B . n 
B 1 146 VAL 146 142 142 VAL VAL B . n 
B 1 147 GLN 147 143 143 GLN GLN B . n 
B 1 148 MSE 148 144 144 MSE MSE B . n 
B 1 149 MSE 149 145 145 MSE MSE B . n 
B 1 150 THR 150 146 146 THR THR B . n 
B 1 151 ALA 151 147 147 ALA ALA B . n 
B 1 152 LYS 152 148 148 LYS LYS B . n 
B 1 153 ASN 153 149 149 ASN ASN B . n 
B 1 154 GLY 154 150 ?   ?   ?   B . n 
B 1 155 LEU 155 151 ?   ?   ?   B . n 
C 1 1   GLY 1   -3  ?   ?   ?   C . n 
C 1 2   PRO 2   -2  ?   ?   ?   C . n 
C 1 3   HIS 3   -1  ?   ?   ?   C . n 
C 1 4   MSE 4   0   ?   ?   ?   C . n 
C 1 5   ALA 5   1   ?   ?   ?   C . n 
C 1 6   ASP 6   2   ?   ?   ?   C . n 
C 1 7   GLN 7   3   ?   ?   ?   C . n 
C 1 8   LEU 8   4   ?   ?   ?   C . n 
C 1 9   THR 9   5   5   THR THR C . n 
C 1 10  GLU 10  6   6   GLU GLU C . n 
C 1 11  GLU 11  7   7   GLU GLU C . n 
C 1 12  GLN 12  8   8   GLN GLN C . n 
C 1 13  ILE 13  9   9   ILE ILE C . n 
C 1 14  ALA 14  10  10  ALA ALA C . n 
C 1 15  GLU 15  11  11  GLU GLU C . n 
C 1 16  PHE 16  12  12  PHE PHE C . n 
C 1 17  LYS 17  13  13  LYS LYS C . n 
C 1 18  GLU 18  14  14  GLU GLU C . n 
C 1 19  ALA 19  15  15  ALA ALA C . n 
C 1 20  PHE 20  16  16  PHE PHE C . n 
C 1 21  SER 21  17  17  SER SER C . n 
C 1 22  LEU 22  18  18  LEU LEU C . n 
C 1 23  PHE 23  19  19  PHE PHE C . n 
C 1 24  ASP 24  20  20  ASP ASP C . n 
C 1 25  LYS 25  21  21  LYS LYS C . n 
C 1 26  ASP 26  22  22  ASP ASP C . n 
C 1 27  GLY 27  23  23  GLY GLY C . n 
C 1 28  ASP 28  24  24  ASP ASP C . n 
C 1 29  GLY 29  25  25  GLY GLY C . n 
C 1 30  THR 30  26  26  THR THR C . n 
C 1 31  ILE 31  27  27  ILE ILE C . n 
C 1 32  THR 32  28  28  THR THR C . n 
C 1 33  THR 33  29  29  THR THR C . n 
C 1 34  LYS 34  30  30  LYS LYS C . n 
C 1 35  GLU 35  31  31  GLU GLU C . n 
C 1 36  LEU 36  32  32  LEU LEU C . n 
C 1 37  GLY 37  33  33  GLY GLY C . n 
C 1 38  THR 38  34  34  THR THR C . n 
C 1 39  VAL 39  35  35  VAL VAL C . n 
C 1 40  MSE 40  36  36  MSE MSE C . n 
C 1 41  ARG 41  37  37  ARG ARG C . n 
C 1 42  SER 42  38  38  SER SER C . n 
C 1 43  LEU 43  39  39  LEU LEU C . n 
C 1 44  GLY 44  40  40  GLY GLY C . n 
C 1 45  GLN 45  41  41  GLN GLN C . n 
C 1 46  ASN 46  42  42  ASN ASN C . n 
C 1 47  PRO 47  43  43  PRO PRO C . n 
C 1 48  THR 48  44  44  THR THR C . n 
C 1 49  GLU 49  45  45  GLU GLU C . n 
C 1 50  ALA 50  46  46  ALA ALA C . n 
C 1 51  GLU 51  47  47  GLU GLU C . n 
C 1 52  LEU 52  48  48  LEU LEU C . n 
C 1 53  GLN 53  49  49  GLN GLN C . n 
C 1 54  ASP 54  50  50  ASP ASP C . n 
C 1 55  MSE 55  51  51  MSE MSE C . n 
C 1 56  ILE 56  52  52  ILE ILE C . n 
C 1 57  ASN 57  53  53  ASN ASN C . n 
C 1 58  GLU 58  54  54  GLU GLU C . n 
C 1 59  VAL 59  55  55  VAL VAL C . n 
C 1 60  ASP 60  56  56  ASP ASP C . n 
C 1 61  ALA 61  57  57  ALA ALA C . n 
C 1 62  ASP 62  58  58  ASP ASP C . n 
C 1 63  GLY 63  59  59  GLY GLY C . n 
C 1 64  ASN 64  60  60  ASN ASN C . n 
C 1 65  GLY 65  61  61  GLY GLY C . n 
C 1 66  THR 66  62  62  THR THR C . n 
C 1 67  ILE 67  63  63  ILE ILE C . n 
C 1 68  ASP 68  64  64  ASP ASP C . n 
C 1 69  PHE 69  65  65  PHE PHE C . n 
C 1 70  PRO 70  66  66  PRO PRO C . n 
C 1 71  GLU 71  67  67  GLU GLU C . n 
C 1 72  PHE 72  68  68  PHE PHE C . n 
C 1 73  LEU 73  69  69  LEU LEU C . n 
C 1 74  THR 74  70  70  THR THR C . n 
C 1 75  MSE 75  71  71  MSE MSE C . n 
C 1 76  MSE 76  72  72  MSE MSE C . n 
C 1 77  ALA 77  73  73  ALA ALA C . n 
C 1 78  ARG 78  74  74  ARG ARG C . n 
C 1 79  LYS 79  75  ?   ?   ?   C . n 
C 1 80  MSE 80  76  ?   ?   ?   C . n 
C 1 81  LYS 81  77  ?   ?   ?   C . n 
C 1 82  ASP 82  78  ?   ?   ?   C . n 
C 1 83  THR 83  79  ?   ?   ?   C . n 
C 1 84  ASP 84  80  ?   ?   ?   C . n 
C 1 85  SER 85  81  81  SER SER C . n 
C 1 86  GLU 86  82  82  GLU GLU C . n 
C 1 87  GLU 87  83  83  GLU GLU C . n 
C 1 88  GLU 88  84  84  GLU GLU C . n 
C 1 89  ILE 89  85  85  ILE ILE C . n 
C 1 90  ARG 90  86  86  ARG ARG C . n 
C 1 91  GLU 91  87  87  GLU GLU C . n 
C 1 92  ALA 92  88  88  ALA ALA C . n 
C 1 93  PHE 93  89  89  PHE PHE C . n 
C 1 94  ARG 94  90  90  ARG ARG C . n 
C 1 95  VAL 95  91  91  VAL VAL C . n 
C 1 96  PHE 96  92  92  PHE PHE C . n 
C 1 97  ASP 97  93  93  ASP ASP C . n 
C 1 98  LYS 98  94  94  LYS LYS C . n 
C 1 99  ASP 99  95  95  ASP ASP C . n 
C 1 100 GLY 100 96  96  GLY GLY C . n 
C 1 101 ASN 101 97  97  ASN ASN C . n 
C 1 102 GLY 102 98  98  GLY GLY C . n 
C 1 103 TYR 103 99  99  TYR TYR C . n 
C 1 104 ILE 104 100 100 ILE ILE C . n 
C 1 105 SER 105 101 101 SER SER C . n 
C 1 106 ALA 106 102 102 ALA ALA C . n 
C 1 107 ALA 107 103 103 ALA ALA C . n 
C 1 108 GLU 108 104 104 GLU GLU C . n 
C 1 109 LEU 109 105 105 LEU LEU C . n 
C 1 110 ARG 110 106 106 ARG ARG C . n 
C 1 111 HIS 111 107 107 HIS HIS C . n 
C 1 112 VAL 112 108 108 VAL VAL C . n 
C 1 113 MSE 113 109 109 MSE MSE C . n 
C 1 114 THR 114 110 110 THR THR C . n 
C 1 115 ASN 115 111 111 ASN ASN C . n 
C 1 116 LEU 116 112 112 LEU LEU C . n 
C 1 117 GLY 117 113 113 GLY GLY C . n 
C 1 118 GLU 118 114 114 GLU GLU C . n 
C 1 119 LYS 119 115 115 LYS LYS C . n 
C 1 120 LEU 120 116 116 LEU LEU C . n 
C 1 121 THR 121 117 117 THR THR C . n 
C 1 122 ASP 122 118 118 ASP ASP C . n 
C 1 123 GLU 123 119 119 GLU GLU C . n 
C 1 124 GLU 124 120 120 GLU GLU C . n 
C 1 125 VAL 125 121 121 VAL VAL C . n 
C 1 126 ASP 126 122 122 ASP ASP C . n 
C 1 127 GLU 127 123 123 GLU GLU C . n 
C 1 128 MSE 128 124 124 MSE MSE C . n 
C 1 129 ILE 129 125 125 ILE ILE C . n 
C 1 130 ARG 130 126 126 ARG ARG C . n 
C 1 131 GLU 131 127 127 GLU GLU C . n 
C 1 132 ALA 132 128 128 ALA ALA C . n 
C 1 133 ASP 133 129 129 ASP ASP C . n 
C 1 134 ILE 134 130 130 ILE ILE C . n 
C 1 135 ASP 135 131 131 ASP ASP C . n 
C 1 136 GLY 136 132 132 GLY GLY C . n 
C 1 137 ASP 137 133 133 ASP ASP C . n 
C 1 138 GLY 138 134 134 GLY GLY C . n 
C 1 139 GLN 139 135 135 GLN GLN C . n 
C 1 140 VAL 140 136 136 VAL VAL C . n 
C 1 141 ASN 141 137 137 ASN ASN C . n 
C 1 142 TYR 142 138 138 TYR TYR C . n 
C 1 143 GLU 143 139 139 GLU GLU C . n 
C 1 144 GLU 144 140 140 GLU GLU C . n 
C 1 145 PHE 145 141 141 PHE PHE C . n 
C 1 146 VAL 146 142 142 VAL VAL C . n 
C 1 147 GLN 147 143 143 GLN GLN C . n 
C 1 148 MSE 148 144 144 MSE MSE C . n 
C 1 149 MSE 149 145 145 MSE MSE C . n 
C 1 150 THR 150 146 146 THR THR C . n 
C 1 151 ALA 151 147 147 ALA ALA C . n 
C 1 152 LYS 152 148 148 LYS LYS C . n 
C 1 153 ASN 153 149 ?   ?   ?   C . n 
C 1 154 GLY 154 150 ?   ?   ?   C . n 
C 1 155 LEU 155 151 ?   ?   ?   C . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        KN9 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   KN9 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
D 2 CA  1  201 201 CA  CA  A . 
E 2 CA  1  202 202 CA  CA  A . 
F 2 CA  1  203 203 CA  CA  A . 
G 2 CA  1  204 204 CA  CA  A . 
H 3 KN9 1  205 205 KN9 KN9 A . 
I 2 CA  1  201 201 CA  CA  B . 
J 2 CA  1  202 202 CA  CA  B . 
K 2 CA  1  203 203 CA  CA  B . 
L 2 CA  1  204 204 CA  CA  B . 
M 3 KN9 1  205 205 KN9 KN9 B . 
N 2 CA  1  201 201 CA  CA  C . 
O 2 CA  1  202 202 CA  CA  C . 
P 2 CA  1  203 203 CA  CA  C . 
Q 2 CA  1  204 204 CA  CA  C . 
R 3 KN9 1  205 205 KN9 KN9 C . 
S 4 HOH 1  301 54  HOH HOH A . 
S 4 HOH 2  302 51  HOH HOH A . 
S 4 HOH 3  303 67  HOH HOH A . 
S 4 HOH 4  304 29  HOH HOH A . 
S 4 HOH 5  305 2   HOH HOH A . 
S 4 HOH 6  306 48  HOH HOH A . 
S 4 HOH 7  307 69  HOH HOH A . 
S 4 HOH 8  308 65  HOH HOH A . 
S 4 HOH 9  309 52  HOH HOH A . 
S 4 HOH 10 310 5   HOH HOH A . 
S 4 HOH 11 311 68  HOH HOH A . 
S 4 HOH 12 312 7   HOH HOH A . 
S 4 HOH 13 313 27  HOH HOH A . 
S 4 HOH 14 314 58  HOH HOH A . 
S 4 HOH 15 315 46  HOH HOH A . 
S 4 HOH 16 316 91  HOH HOH A . 
S 4 HOH 17 317 84  HOH HOH A . 
S 4 HOH 18 318 4   HOH HOH A . 
S 4 HOH 19 319 6   HOH HOH A . 
S 4 HOH 20 320 95  HOH HOH A . 
S 4 HOH 21 321 26  HOH HOH A . 
S 4 HOH 22 322 70  HOH HOH A . 
S 4 HOH 23 323 92  HOH HOH A . 
S 4 HOH 24 324 53  HOH HOH A . 
S 4 HOH 25 325 94  HOH HOH A . 
S 4 HOH 26 326 93  HOH HOH A . 
S 4 HOH 27 327 85  HOH HOH A . 
S 4 HOH 28 328 55  HOH HOH A . 
S 4 HOH 29 329 87  HOH HOH A . 
S 4 HOH 30 330 61  HOH HOH A . 
S 4 HOH 31 331 60  HOH HOH A . 
S 4 HOH 32 332 63  HOH HOH A . 
S 4 HOH 33 333 57  HOH HOH A . 
S 4 HOH 34 334 71  HOH HOH A . 
S 4 HOH 35 335 59  HOH HOH A . 
S 4 HOH 36 336 47  HOH HOH A . 
S 4 HOH 37 337 96  HOH HOH A . 
S 4 HOH 38 338 64  HOH HOH A . 
S 4 HOH 39 339 82  HOH HOH A . 
T 4 HOH 1  301 77  HOH HOH B . 
T 4 HOH 2  302 22  HOH HOH B . 
T 4 HOH 3  303 30  HOH HOH B . 
T 4 HOH 4  304 101 HOH HOH B . 
T 4 HOH 5  305 76  HOH HOH B . 
T 4 HOH 6  306 10  HOH HOH B . 
T 4 HOH 7  307 37  HOH HOH B . 
T 4 HOH 8  308 80  HOH HOH B . 
T 4 HOH 9  309 8   HOH HOH B . 
T 4 HOH 10 310 12  HOH HOH B . 
T 4 HOH 11 311 99  HOH HOH B . 
T 4 HOH 12 312 88  HOH HOH B . 
T 4 HOH 13 313 15  HOH HOH B . 
T 4 HOH 14 314 42  HOH HOH B . 
T 4 HOH 15 315 35  HOH HOH B . 
T 4 HOH 16 316 78  HOH HOH B . 
T 4 HOH 17 317 75  HOH HOH B . 
T 4 HOH 18 318 36  HOH HOH B . 
T 4 HOH 19 319 13  HOH HOH B . 
T 4 HOH 20 320 31  HOH HOH B . 
T 4 HOH 21 321 16  HOH HOH B . 
T 4 HOH 22 322 72  HOH HOH B . 
T 4 HOH 23 323 32  HOH HOH B . 
T 4 HOH 24 324 98  HOH HOH B . 
T 4 HOH 25 325 49  HOH HOH B . 
T 4 HOH 26 326 74  HOH HOH B . 
T 4 HOH 27 327 100 HOH HOH B . 
U 4 HOH 1  301 103 HOH HOH C . 
U 4 HOH 2  302 83  HOH HOH C . 
U 4 HOH 3  303 89  HOH HOH C . 
U 4 HOH 4  304 43  HOH HOH C . 
U 4 HOH 5  305 44  HOH HOH C . 
U 4 HOH 6  306 21  HOH HOH C . 
U 4 HOH 7  307 14  HOH HOH C . 
U 4 HOH 8  308 24  HOH HOH C . 
U 4 HOH 9  309 97  HOH HOH C . 
U 4 HOH 10 310 40  HOH HOH C . 
U 4 HOH 11 311 18  HOH HOH C . 
U 4 HOH 12 312 41  HOH HOH C . 
U 4 HOH 13 313 20  HOH HOH C . 
U 4 HOH 14 314 17  HOH HOH C . 
U 4 HOH 15 315 9   HOH HOH C . 
U 4 HOH 16 316 73  HOH HOH C . 
U 4 HOH 17 317 50  HOH HOH C . 
U 4 HOH 18 318 23  HOH HOH C . 
U 4 HOH 19 319 38  HOH HOH C . 
U 4 HOH 20 320 81  HOH HOH C . 
U 4 HOH 21 321 102 HOH HOH C . 
U 4 HOH 22 322 90  HOH HOH C . 
U 4 HOH 23 323 34  HOH HOH C . 
U 4 HOH 24 324 33  HOH HOH C . 
U 4 HOH 25 325 39  HOH HOH C . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 B GLU 11  ? CG  ? B GLU 15  CG  
2  1 Y 1 B GLU 11  ? CD  ? B GLU 15  CD  
3  1 Y 1 B GLU 11  ? OE1 ? B GLU 15  OE1 
4  1 Y 1 B GLU 11  ? OE2 ? B GLU 15  OE2 
5  1 Y 1 B GLU 14  ? CG  ? B GLU 18  CG  
6  1 Y 1 B GLU 14  ? CD  ? B GLU 18  CD  
7  1 Y 1 B GLU 14  ? OE1 ? B GLU 18  OE1 
8  1 Y 1 B GLU 14  ? OE2 ? B GLU 18  OE2 
9  1 Y 1 C GLU 6   ? CG  ? C GLU 10  CG  
10 1 Y 1 C GLU 6   ? CD  ? C GLU 10  CD  
11 1 Y 1 C GLU 6   ? OE1 ? C GLU 10  OE1 
12 1 Y 1 C GLU 6   ? OE2 ? C GLU 10  OE2 
13 1 Y 1 C GLN 8   ? CG  ? C GLN 12  CG  
14 1 Y 1 C GLN 8   ? CD  ? C GLN 12  CD  
15 1 Y 1 C GLN 8   ? OE1 ? C GLN 12  OE1 
16 1 Y 1 C GLN 8   ? NE2 ? C GLN 12  NE2 
17 1 Y 1 C LEU 18  ? CG  ? C LEU 22  CG  
18 1 Y 1 C LEU 18  ? CD1 ? C LEU 22  CD1 
19 1 Y 1 C LEU 18  ? CD2 ? C LEU 22  CD2 
20 1 Y 1 C ARG 74  ? CG  ? C ARG 78  CG  
21 1 Y 1 C ARG 74  ? CD  ? C ARG 78  CD  
22 1 Y 1 C ARG 74  ? NE  ? C ARG 78  NE  
23 1 Y 1 C ARG 74  ? CZ  ? C ARG 78  CZ  
24 1 Y 1 C ARG 74  ? NH1 ? C ARG 78  NH1 
25 1 Y 1 C ARG 74  ? NH2 ? C ARG 78  NH2 
26 1 Y 1 C GLU 127 ? CG  ? C GLU 131 CG  
27 1 Y 1 C GLU 127 ? CD  ? C GLU 131 CD  
28 1 Y 1 C GLU 127 ? OE1 ? C GLU 131 OE1 
29 1 Y 1 C GLU 127 ? OE2 ? C GLU 131 OE2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.20.1_4487 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? autoPX  ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   92.470 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9JQI 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     69.336 
_cell.length_a_esd                 ? 
_cell.length_b                     40.264 
_cell.length_b_esd                 ? 
_cell.length_c                     173.413 
_cell.length_c_esd                 ? 
_cell.volume                       483675.035 
_cell.volume_esd                   ? 
_cell.Z_PDB                        12 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9JQI 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            'C 2y' 
_symmetry.space_group_name_H-M             'C 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9JQI 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.26 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          45.52 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              6.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    'sodium acetate, sodium cacodylate, PEG 8000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            277 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS3 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-09-23 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97861 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL19U1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97861 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL19U1 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          29.25 
_reflns.entry_id                                       9JQI 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.10 
_reflns.d_resolution_low                               57.75 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     28412 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.9 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.2 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          7.6 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.985 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.158 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.10 
_reflns_shell.d_res_low                                     2.21 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           2.8 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             4103 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               6.5 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.775 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          100.0 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.689 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               40.18 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9JQI 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.10 
_refine.ls_d_res_low                             57.75 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     28410 
_refine.ls_number_reflns_R_free                  1999 
_refine.ls_number_reflns_R_work                  26411 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.87 
_refine.ls_percent_reflns_R_free                 7.04 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2512 
_refine.ls_R_factor_R_free                       0.2882 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2484 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      6m7h 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 28.1391 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.3195 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.10 
_refine_hist.d_res_low                        57.75 
_refine_hist.number_atoms_solvent             91 
_refine_hist.number_atoms_total               3499 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3294 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         114 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0020  ? 3445 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.5042  ? 4628 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0348  ? 493  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0034  ? 626  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 12.5034 ? 468  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.10 2.15  . . 138 1824 99.95  . . . . 0.2978 . . . . . . . . . . . 0.3434 
'X-RAY DIFFRACTION' 2.15 2.21  . . 149 1889 99.95  . . . . 0.2685 . . . . . . . . . . . 0.3396 
'X-RAY DIFFRACTION' 2.21 2.27  . . 137 1836 99.60  . . . . 0.2811 . . . . . . . . . . . 0.3218 
'X-RAY DIFFRACTION' 2.27 2.35  . . 134 1934 100.00 . . . . 0.2675 . . . . . . . . . . . 0.3278 
'X-RAY DIFFRACTION' 2.35 2.43  . . 140 1818 100.00 . . . . 0.2632 . . . . . . . . . . . 0.3437 
'X-RAY DIFFRACTION' 2.43 2.53  . . 149 1921 100.00 . . . . 0.2628 . . . . . . . . . . . 0.3095 
'X-RAY DIFFRACTION' 2.53 2.64  . . 140 1863 99.95  . . . . 0.2568 . . . . . . . . . . . 0.3396 
'X-RAY DIFFRACTION' 2.64 2.78  . . 145 1869 99.75  . . . . 0.2539 . . . . . . . . . . . 0.2930 
'X-RAY DIFFRACTION' 2.78 2.96  . . 135 1876 99.95  . . . . 0.2769 . . . . . . . . . . . 0.3413 
'X-RAY DIFFRACTION' 2.96 3.19  . . 127 1895 100.00 . . . . 0.2637 . . . . . . . . . . . 0.3097 
'X-RAY DIFFRACTION' 3.19 3.51  . . 157 1883 100.00 . . . . 0.2496 . . . . . . . . . . . 0.2922 
'X-RAY DIFFRACTION' 3.51 4.01  . . 155 1928 99.76  . . . . 0.2307 . . . . . . . . . . . 0.2461 
'X-RAY DIFFRACTION' 4.01 5.06  . . 140 1917 99.90  . . . . 0.2138 . . . . . . . . . . . 0.2492 
'X-RAY DIFFRACTION' 5.06 57.75 . . 153 1958 99.39  . . . . 0.2409 . . . . . . . . . . . 0.2632 
# 
_struct.entry_id                     9JQI 
_struct.title                        'Crystal structure of calmodulin in complex with KN93 (1:1 complex)' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9JQI 
_struct_keywords.text            'calmodulin, KN93, METAL BINDING PROTEIN' 
_struct_keywords.pdbx_keywords   'METAL BINDING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 1 ? 
D N N 2 ? 
E N N 2 ? 
F N N 2 ? 
G N N 2 ? 
H N N 3 ? 
I N N 2 ? 
J N N 2 ? 
K N N 2 ? 
L N N 2 ? 
M N N 3 ? 
N N N 2 ? 
O N N 2 ? 
P N N 2 ? 
Q N N 2 ? 
R N N 3 ? 
S N N 4 ? 
T N N 4 ? 
U N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    CALM1_HUMAN 
_struct_ref.pdbx_db_accession          P0DP23 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDT
DSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK
;
_struct_ref.pdbx_align_begin           1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9JQI A 4 ? 152 ? P0DP23 1 ? 149 ? 0 148 
2 1 9JQI B 4 ? 152 ? P0DP23 1 ? 149 ? 0 148 
3 1 9JQI C 4 ? 152 ? P0DP23 1 ? 149 ? 0 148 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9JQI GLY A 1   ? UNP P0DP23 ? ? 'expression tag' -3  1  
1 9JQI PRO A 2   ? UNP P0DP23 ? ? 'expression tag' -2  2  
1 9JQI HIS A 3   ? UNP P0DP23 ? ? 'expression tag' -1  3  
1 9JQI ASN A 153 ? UNP P0DP23 ? ? 'expression tag' 149 4  
1 9JQI GLY A 154 ? UNP P0DP23 ? ? 'expression tag' 150 5  
1 9JQI LEU A 155 ? UNP P0DP23 ? ? 'expression tag' 151 6  
2 9JQI GLY B 1   ? UNP P0DP23 ? ? 'expression tag' -3  7  
2 9JQI PRO B 2   ? UNP P0DP23 ? ? 'expression tag' -2  8  
2 9JQI HIS B 3   ? UNP P0DP23 ? ? 'expression tag' -1  9  
2 9JQI ASN B 153 ? UNP P0DP23 ? ? 'expression tag' 149 10 
2 9JQI GLY B 154 ? UNP P0DP23 ? ? 'expression tag' 150 11 
2 9JQI LEU B 155 ? UNP P0DP23 ? ? 'expression tag' 151 12 
3 9JQI GLY C 1   ? UNP P0DP23 ? ? 'expression tag' -3  13 
3 9JQI PRO C 2   ? UNP P0DP23 ? ? 'expression tag' -2  14 
3 9JQI HIS C 3   ? UNP P0DP23 ? ? 'expression tag' -1  15 
3 9JQI ASN C 153 ? UNP P0DP23 ? ? 'expression tag' 149 16 
3 9JQI GLY C 154 ? UNP P0DP23 ? ? 'expression tag' 150 17 
3 9JQI LEU C 155 ? UNP P0DP23 ? ? 'expression tag' 151 18 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_and_software_defined_assembly PISA monomeric 1 
2 author_and_software_defined_assembly PISA monomeric 1 
3 author_and_software_defined_assembly PISA monomeric 1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 90   ? 
1 MORE         -13  ? 
1 'SSA (A^2)'  8620 ? 
2 'ABSA (A^2)' 90   ? 
2 MORE         -13  ? 
2 'SSA (A^2)'  8530 ? 
3 'ABSA (A^2)' 90   ? 
3 MORE         -13  ? 
3 'SSA (A^2)'  8400 ? 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,D,E,F,G,H,S 
2 1 B,I,J,K,L,M,T 
3 1 C,N,O,P,Q,R,U 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 THR A 9   ? ASP A 24  ? THR A 5   ASP A 20  1 ? 16 
HELX_P HELX_P2  AA2 THR A 32  ? LEU A 43  ? THR A 28  LEU A 39  1 ? 12 
HELX_P HELX_P3  AA3 THR A 48  ? GLU A 58  ? THR A 44  GLU A 54  1 ? 11 
HELX_P HELX_P4  AA4 ASP A 68  ? MSE A 80  ? ASP A 64  MSE A 76  1 ? 13 
HELX_P HELX_P5  AA5 SER A 85  ? ASP A 97  ? SER A 81  ASP A 93  1 ? 13 
HELX_P HELX_P6  AA6 SER A 105 ? LEU A 116 ? SER A 101 LEU A 112 1 ? 12 
HELX_P HELX_P7  AA7 THR A 121 ? ASP A 133 ? THR A 117 ASP A 129 1 ? 13 
HELX_P HELX_P8  AA8 ASN A 141 ? THR A 150 ? ASN A 137 THR A 146 1 ? 10 
HELX_P HELX_P9  AA9 GLU B 10  ? ASP B 24  ? GLU B 6   ASP B 20  1 ? 15 
HELX_P HELX_P10 AB1 THR B 32  ? LEU B 43  ? THR B 28  LEU B 39  1 ? 12 
HELX_P HELX_P11 AB2 THR B 48  ? GLU B 58  ? THR B 44  GLU B 54  1 ? 11 
HELX_P HELX_P12 AB3 ASP B 68  ? LYS B 79  ? ASP B 64  LYS B 75  1 ? 12 
HELX_P HELX_P13 AB4 GLU B 86  ? ASP B 97  ? GLU B 82  ASP B 93  1 ? 12 
HELX_P HELX_P14 AB5 SER B 105 ? LEU B 116 ? SER B 101 LEU B 112 1 ? 12 
HELX_P HELX_P15 AB6 THR B 121 ? ASP B 133 ? THR B 117 ASP B 129 1 ? 13 
HELX_P HELX_P16 AB7 ASN B 141 ? THR B 150 ? ASN B 137 THR B 146 1 ? 10 
HELX_P HELX_P17 AB8 GLU C 10  ? ASP C 24  ? GLU C 6   ASP C 20  1 ? 15 
HELX_P HELX_P18 AB9 THR C 32  ? LEU C 43  ? THR C 28  LEU C 39  1 ? 12 
HELX_P HELX_P19 AC1 THR C 48  ? ASP C 60  ? THR C 44  ASP C 56  1 ? 13 
HELX_P HELX_P20 AC2 ASP C 68  ? MSE C 76  ? ASP C 64  MSE C 72  1 ? 9  
HELX_P HELX_P21 AC3 GLU C 86  ? ASP C 97  ? GLU C 82  ASP C 93  1 ? 12 
HELX_P HELX_P22 AC4 SER C 105 ? LEU C 116 ? SER C 101 LEU C 112 1 ? 12 
HELX_P HELX_P23 AC5 THR C 121 ? ASP C 133 ? THR C 117 ASP C 129 1 ? 13 
HELX_P HELX_P24 AC6 ASN C 141 ? THR C 150 ? ASN C 137 THR C 146 1 ? 10 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
covale1  covale both ? A VAL 39  C   ? ? ? 1_555 A MSE 40  N  ? ? A VAL 35  A MSE 36  1_555 ? ? ? ? ? ? ? 1.331 ? ? 
covale2  covale both ? A MSE 40  C   ? ? ? 1_555 A ARG 41  N  ? ? A MSE 36  A ARG 37  1_555 ? ? ? ? ? ? ? 1.335 ? ? 
covale3  covale both ? A ASP 54  C   ? ? ? 1_555 A MSE 55  N  ? ? A ASP 50  A MSE 51  1_555 ? ? ? ? ? ? ? 1.331 ? ? 
covale4  covale both ? A MSE 55  C   ? ? ? 1_555 A ILE 56  N  ? ? A MSE 51  A ILE 52  1_555 ? ? ? ? ? ? ? 1.334 ? ? 
covale5  covale both ? A THR 74  C   ? ? ? 1_555 A MSE 75  N  ? ? A THR 70  A MSE 71  1_555 ? ? ? ? ? ? ? 1.330 ? ? 
covale6  covale both ? A MSE 75  C   ? ? ? 1_555 A MSE 76  N  ? ? A MSE 71  A MSE 72  1_555 ? ? ? ? ? ? ? 1.330 ? ? 
covale7  covale both ? A MSE 76  C   ? ? ? 1_555 A ALA 77  N  ? ? A MSE 72  A ALA 73  1_555 ? ? ? ? ? ? ? 1.336 ? ? 
covale8  covale both ? A LYS 79  C   ? ? ? 1_555 A MSE 80  N  ? ? A LYS 75  A MSE 76  1_555 ? ? ? ? ? ? ? 1.330 ? ? 
covale9  covale both ? A VAL 112 C   ? ? ? 1_555 A MSE 113 N  ? ? A VAL 108 A MSE 109 1_555 ? ? ? ? ? ? ? 1.330 ? ? 
covale10 covale both ? A MSE 113 C   ? ? ? 1_555 A THR 114 N  ? ? A MSE 109 A THR 110 1_555 ? ? ? ? ? ? ? 1.335 ? ? 
covale11 covale both ? A GLU 127 C   ? ? ? 1_555 A MSE 128 N  ? ? A GLU 123 A MSE 124 1_555 ? ? ? ? ? ? ? 1.328 ? ? 
covale12 covale both ? A MSE 128 C   ? ? ? 1_555 A ILE 129 N  ? ? A MSE 124 A ILE 125 1_555 ? ? ? ? ? ? ? 1.335 ? ? 
covale13 covale both ? A GLN 147 C   ? ? ? 1_555 A MSE 148 N  ? ? A GLN 143 A MSE 144 1_555 ? ? ? ? ? ? ? 1.329 ? ? 
covale14 covale both ? A MSE 148 C   ? ? ? 1_555 A MSE 149 N  ? ? A MSE 144 A MSE 145 1_555 ? ? ? ? ? ? ? 1.330 ? ? 
covale15 covale both ? A MSE 149 C   ? ? ? 1_555 A THR 150 N  ? ? A MSE 145 A THR 146 1_555 ? ? ? ? ? ? ? 1.328 ? ? 
covale16 covale both ? B VAL 39  C   ? ? ? 1_555 B MSE 40  N  ? ? B VAL 35  B MSE 36  1_555 ? ? ? ? ? ? ? 1.332 ? ? 
covale17 covale both ? B MSE 40  C   ? ? ? 1_555 B ARG 41  N  ? ? B MSE 36  B ARG 37  1_555 ? ? ? ? ? ? ? 1.334 ? ? 
covale18 covale both ? B ASP 54  C   ? ? ? 1_555 B MSE 55  N  ? ? B ASP 50  B MSE 51  1_555 ? ? ? ? ? ? ? 1.330 ? ? 
covale19 covale both ? B MSE 55  C   ? ? ? 1_555 B ILE 56  N  ? ? B MSE 51  B ILE 52  1_555 ? ? ? ? ? ? ? 1.334 ? ? 
covale20 covale both ? B THR 74  C   ? ? ? 1_555 B MSE 75  N  ? ? B THR 70  B MSE 71  1_555 ? ? ? ? ? ? ? 1.329 ? ? 
covale21 covale both ? B MSE 75  C   ? ? ? 1_555 B MSE 76  N  ? ? B MSE 71  B MSE 72  1_555 ? ? ? ? ? ? ? 1.331 ? ? 
covale22 covale both ? B MSE 76  C   ? ? ? 1_555 B ALA 77  N  ? ? B MSE 72  B ALA 73  1_555 ? ? ? ? ? ? ? 1.335 ? ? 
covale23 covale both ? B VAL 112 C   ? ? ? 1_555 B MSE 113 N  ? ? B VAL 108 B MSE 109 1_555 ? ? ? ? ? ? ? 1.330 ? ? 
covale24 covale both ? B MSE 113 C   ? ? ? 1_555 B THR 114 N  ? ? B MSE 109 B THR 110 1_555 ? ? ? ? ? ? ? 1.336 ? ? 
covale25 covale both ? B GLU 127 C   ? ? ? 1_555 B MSE 128 N  ? ? B GLU 123 B MSE 124 1_555 ? ? ? ? ? ? ? 1.331 ? ? 
covale26 covale both ? B MSE 128 C   ? ? ? 1_555 B ILE 129 N  ? ? B MSE 124 B ILE 125 1_555 ? ? ? ? ? ? ? 1.335 ? ? 
covale27 covale both ? B GLN 147 C   ? ? ? 1_555 B MSE 148 N  ? ? B GLN 143 B MSE 144 1_555 ? ? ? ? ? ? ? 1.329 ? ? 
covale28 covale both ? B MSE 148 C   ? ? ? 1_555 B MSE 149 N  ? ? B MSE 144 B MSE 145 1_555 ? ? ? ? ? ? ? 1.330 ? ? 
covale29 covale both ? B MSE 149 C   ? ? ? 1_555 B THR 150 N  ? ? B MSE 145 B THR 146 1_555 ? ? ? ? ? ? ? 1.326 ? ? 
covale30 covale both ? C VAL 39  C   ? ? ? 1_555 C MSE 40  N  ? ? C VAL 35  C MSE 36  1_555 ? ? ? ? ? ? ? 1.331 ? ? 
covale31 covale both ? C MSE 40  C   ? ? ? 1_555 C ARG 41  N  ? ? C MSE 36  C ARG 37  1_555 ? ? ? ? ? ? ? 1.335 ? ? 
covale32 covale both ? C ASP 54  C   ? ? ? 1_555 C MSE 55  N  ? ? C ASP 50  C MSE 51  1_555 ? ? ? ? ? ? ? 1.326 ? ? 
covale33 covale both ? C MSE 55  C   ? ? ? 1_555 C ILE 56  N  ? ? C MSE 51  C ILE 52  1_555 ? ? ? ? ? ? ? 1.335 ? ? 
covale34 covale both ? C THR 74  C   ? ? ? 1_555 C MSE 75  N  ? ? C THR 70  C MSE 71  1_555 ? ? ? ? ? ? ? 1.330 ? ? 
covale35 covale both ? C MSE 75  C   ? ? ? 1_555 C MSE 76  N  ? ? C MSE 71  C MSE 72  1_555 ? ? ? ? ? ? ? 1.327 ? ? 
covale36 covale both ? C MSE 76  C   ? ? ? 1_555 C ALA 77  N  ? ? C MSE 72  C ALA 73  1_555 ? ? ? ? ? ? ? 1.333 ? ? 
covale37 covale both ? C VAL 112 C   ? ? ? 1_555 C MSE 113 N  ? ? C VAL 108 C MSE 109 1_555 ? ? ? ? ? ? ? 1.330 ? ? 
covale38 covale both ? C MSE 113 C   ? ? ? 1_555 C THR 114 N  ? ? C MSE 109 C THR 110 1_555 ? ? ? ? ? ? ? 1.337 ? ? 
covale39 covale both ? C GLU 127 C   ? ? ? 1_555 C MSE 128 N  ? ? C GLU 123 C MSE 124 1_555 ? ? ? ? ? ? ? 1.329 ? ? 
covale40 covale both ? C MSE 128 C   ? ? ? 1_555 C ILE 129 N  ? ? C MSE 124 C ILE 125 1_555 ? ? ? ? ? ? ? 1.335 ? ? 
covale41 covale both ? C GLN 147 C   ? ? ? 1_555 C MSE 148 N  ? ? C GLN 143 C MSE 144 1_555 ? ? ? ? ? ? ? 1.329 ? ? 
covale42 covale both ? C MSE 148 C   ? ? ? 1_555 C MSE 149 N  ? ? C MSE 144 C MSE 145 1_555 ? ? ? ? ? ? ? 1.330 ? ? 
covale43 covale both ? C MSE 149 C   ? ? ? 1_555 C THR 150 N  ? ? C MSE 145 C THR 146 1_555 ? ? ? ? ? ? ? 1.328 ? ? 
metalc1  metalc ?    ? A ASP 24  OD1 ? ? ? 1_555 D CA  .   CA ? ? A ASP 20  A CA  201 1_555 ? ? ? ? ? ? ? 2.465 ? ? 
metalc2  metalc ?    ? A ASP 26  OD1 ? ? ? 1_555 D CA  .   CA ? ? A ASP 22  A CA  201 1_555 ? ? ? ? ? ? ? 2.292 ? ? 
metalc3  metalc ?    ? A ASP 28  OD1 ? ? ? 1_555 D CA  .   CA ? ? A ASP 24  A CA  201 1_555 ? ? ? ? ? ? ? 2.545 ? ? 
metalc4  metalc ?    ? A THR 30  O   ? ? ? 1_555 D CA  .   CA ? ? A THR 26  A CA  201 1_555 ? ? ? ? ? ? ? 2.286 ? ? 
metalc5  metalc ?    ? A GLU 35  OE1 ? ? ? 1_555 D CA  .   CA ? ? A GLU 31  A CA  201 1_555 ? ? ? ? ? ? ? 2.450 ? ? 
metalc6  metalc ?    ? A GLU 35  OE2 ? ? ? 1_555 D CA  .   CA ? ? A GLU 31  A CA  201 1_555 ? ? ? ? ? ? ? 2.624 ? ? 
metalc7  metalc ?    ? A ASP 60  OD1 ? ? ? 1_555 E CA  .   CA ? ? A ASP 56  A CA  202 1_555 ? ? ? ? ? ? ? 2.249 ? ? 
metalc8  metalc ?    ? A ASP 62  OD1 ? ? ? 1_555 E CA  .   CA ? ? A ASP 58  A CA  202 1_555 ? ? ? ? ? ? ? 2.357 ? ? 
metalc9  metalc ?    ? A ASN 64  OD1 ? ? ? 1_555 E CA  .   CA ? ? A ASN 60  A CA  202 1_555 ? ? ? ? ? ? ? 2.248 ? ? 
metalc10 metalc ?    ? A THR 66  O   ? ? ? 1_555 E CA  .   CA ? ? A THR 62  A CA  202 1_555 ? ? ? ? ? ? ? 2.440 ? ? 
metalc11 metalc ?    ? A GLU 71  OE1 ? ? ? 1_555 E CA  .   CA ? ? A GLU 67  A CA  202 1_555 ? ? ? ? ? ? ? 2.354 ? ? 
metalc12 metalc ?    ? A GLU 71  OE2 ? ? ? 1_555 E CA  .   CA ? ? A GLU 67  A CA  202 1_555 ? ? ? ? ? ? ? 2.671 ? ? 
metalc13 metalc ?    ? A ASP 97  OD1 ? ? ? 1_555 F CA  .   CA ? ? A ASP 93  A CA  203 1_555 ? ? ? ? ? ? ? 2.395 ? ? 
metalc14 metalc ?    ? A ASP 99  OD1 ? ? ? 1_555 F CA  .   CA ? ? A ASP 95  A CA  203 1_555 ? ? ? ? ? ? ? 2.311 ? ? 
metalc15 metalc ?    ? A ASN 101 OD1 ? ? ? 1_555 F CA  .   CA ? ? A ASN 97  A CA  203 1_555 ? ? ? ? ? ? ? 2.367 ? ? 
metalc16 metalc ?    ? A TYR 103 O   ? ? ? 1_555 F CA  .   CA ? ? A TYR 99  A CA  203 1_555 ? ? ? ? ? ? ? 2.316 ? ? 
metalc17 metalc ?    ? A GLU 108 OE1 ? ? ? 1_555 F CA  .   CA ? ? A GLU 104 A CA  203 1_555 ? ? ? ? ? ? ? 2.538 ? ? 
metalc18 metalc ?    ? A GLU 108 OE2 ? ? ? 1_555 F CA  .   CA ? ? A GLU 104 A CA  203 1_555 ? ? ? ? ? ? ? 2.653 ? ? 
metalc19 metalc ?    ? A ASP 133 OD1 ? ? ? 1_555 G CA  .   CA ? ? A ASP 129 A CA  204 1_555 ? ? ? ? ? ? ? 2.252 ? ? 
metalc20 metalc ?    ? A ASP 135 OD1 ? ? ? 1_555 G CA  .   CA ? ? A ASP 131 A CA  204 1_555 ? ? ? ? ? ? ? 2.317 ? ? 
metalc21 metalc ?    ? A ASP 137 OD1 ? ? ? 1_555 G CA  .   CA ? ? A ASP 133 A CA  204 1_555 ? ? ? ? ? ? ? 2.312 ? ? 
metalc22 metalc ?    ? A GLN 139 O   ? ? ? 1_555 G CA  .   CA ? ? A GLN 135 A CA  204 1_555 ? ? ? ? ? ? ? 2.429 ? ? 
metalc23 metalc ?    ? A GLU 144 OE1 ? ? ? 1_555 G CA  .   CA ? ? A GLU 140 A CA  204 1_555 ? ? ? ? ? ? ? 2.487 ? ? 
metalc24 metalc ?    ? A GLU 144 OE2 ? ? ? 1_555 G CA  .   CA ? ? A GLU 140 A CA  204 1_555 ? ? ? ? ? ? ? 2.540 ? ? 
metalc25 metalc ?    ? F CA  .   CA  ? ? ? 1_555 S HOH .   O  ? ? A CA  203 A HOH 310 1_555 ? ? ? ? ? ? ? 2.375 ? ? 
metalc26 metalc ?    ? G CA  .   CA  ? ? ? 1_555 S HOH .   O  ? ? A CA  204 A HOH 312 1_555 ? ? ? ? ? ? ? 2.396 ? ? 
metalc27 metalc ?    ? B ASP 24  OD1 ? ? ? 1_555 I CA  .   CA ? ? B ASP 20  B CA  201 1_555 ? ? ? ? ? ? ? 2.322 ? ? 
metalc28 metalc ?    ? B ASP 26  OD1 ? ? ? 1_555 I CA  .   CA ? ? B ASP 22  B CA  201 1_555 ? ? ? ? ? ? ? 2.443 ? ? 
metalc29 metalc ?    ? B ASP 28  OD1 ? ? ? 1_555 I CA  .   CA ? ? B ASP 24  B CA  201 1_555 ? ? ? ? ? ? ? 2.317 ? ? 
metalc30 metalc ?    ? B THR 30  O   ? ? ? 1_555 I CA  .   CA ? ? B THR 26  B CA  201 1_555 ? ? ? ? ? ? ? 2.284 ? ? 
metalc31 metalc ?    ? B GLU 35  OE1 ? ? ? 1_555 I CA  .   CA ? ? B GLU 31  B CA  201 1_555 ? ? ? ? ? ? ? 2.410 ? ? 
metalc32 metalc ?    ? B GLU 35  OE2 ? ? ? 1_555 I CA  .   CA ? ? B GLU 31  B CA  201 1_555 ? ? ? ? ? ? ? 2.899 ? ? 
metalc33 metalc ?    ? B ASP 60  OD1 ? ? ? 1_555 J CA  .   CA ? ? B ASP 56  B CA  202 1_555 ? ? ? ? ? ? ? 2.434 ? ? 
metalc34 metalc ?    ? B ASP 62  OD1 ? ? ? 1_555 J CA  .   CA ? ? B ASP 58  B CA  202 1_555 ? ? ? ? ? ? ? 2.385 ? ? 
metalc35 metalc ?    ? B ASN 64  OD1 ? ? ? 1_555 J CA  .   CA ? ? B ASN 60  B CA  202 1_555 ? ? ? ? ? ? ? 2.317 ? ? 
metalc36 metalc ?    ? B THR 66  O   ? ? ? 1_555 J CA  .   CA ? ? B THR 62  B CA  202 1_555 ? ? ? ? ? ? ? 2.351 ? ? 
metalc37 metalc ?    ? B GLU 71  OE1 ? ? ? 1_555 J CA  .   CA ? ? B GLU 67  B CA  202 1_555 ? ? ? ? ? ? ? 2.367 ? ? 
metalc38 metalc ?    ? B GLU 71  OE2 ? ? ? 1_555 J CA  .   CA ? ? B GLU 67  B CA  202 1_555 ? ? ? ? ? ? ? 2.514 ? ? 
metalc39 metalc ?    ? B ASP 97  OD1 ? ? ? 1_555 K CA  .   CA ? ? B ASP 93  B CA  203 1_555 ? ? ? ? ? ? ? 2.250 ? ? 
metalc40 metalc ?    ? B ASP 99  OD1 ? ? ? 1_555 K CA  .   CA ? ? B ASP 95  B CA  203 1_555 ? ? ? ? ? ? ? 2.362 ? ? 
metalc41 metalc ?    ? B ASN 101 OD1 ? ? ? 1_555 K CA  .   CA ? ? B ASN 97  B CA  203 1_555 ? ? ? ? ? ? ? 2.323 ? ? 
metalc42 metalc ?    ? B TYR 103 O   ? ? ? 1_555 K CA  .   CA ? ? B TYR 99  B CA  203 1_555 ? ? ? ? ? ? ? 2.264 ? ? 
metalc43 metalc ?    ? B GLU 108 OE1 ? ? ? 1_555 K CA  .   CA ? ? B GLU 104 B CA  203 1_555 ? ? ? ? ? ? ? 2.500 ? ? 
metalc44 metalc ?    ? B GLU 108 OE2 ? ? ? 1_555 K CA  .   CA ? ? B GLU 104 B CA  203 1_555 ? ? ? ? ? ? ? 2.727 ? ? 
metalc45 metalc ?    ? B ASP 133 OD1 ? ? ? 1_555 L CA  .   CA ? ? B ASP 129 B CA  204 1_555 ? ? ? ? ? ? ? 2.399 ? ? 
metalc46 metalc ?    ? B ASP 135 OD1 ? ? ? 1_555 L CA  .   CA ? ? B ASP 131 B CA  204 1_555 ? ? ? ? ? ? ? 2.404 ? ? 
metalc47 metalc ?    ? B ASP 137 OD1 ? ? ? 1_555 L CA  .   CA ? ? B ASP 133 B CA  204 1_555 ? ? ? ? ? ? ? 2.342 ? ? 
metalc48 metalc ?    ? B GLN 139 O   ? ? ? 1_555 L CA  .   CA ? ? B GLN 135 B CA  204 1_555 ? ? ? ? ? ? ? 2.307 ? ? 
metalc49 metalc ?    ? B GLU 144 OE1 ? ? ? 1_555 L CA  .   CA ? ? B GLU 140 B CA  204 1_555 ? ? ? ? ? ? ? 2.421 ? ? 
metalc50 metalc ?    ? B GLU 144 OE2 ? ? ? 1_555 L CA  .   CA ? ? B GLU 140 B CA  204 1_555 ? ? ? ? ? ? ? 2.484 ? ? 
metalc51 metalc ?    ? L CA  .   CA  ? ? ? 1_555 T HOH .   O  ? ? B CA  204 B HOH 310 1_555 ? ? ? ? ? ? ? 2.464 ? ? 
metalc52 metalc ?    ? C ASP 24  OD1 ? ? ? 1_555 N CA  .   CA ? ? C ASP 20  C CA  201 1_555 ? ? ? ? ? ? ? 2.255 ? ? 
metalc53 metalc ?    ? C ASP 26  OD1 ? ? ? 1_555 N CA  .   CA ? ? C ASP 22  C CA  201 1_555 ? ? ? ? ? ? ? 2.358 ? ? 
metalc54 metalc ?    ? C ASP 28  OD1 ? ? ? 1_555 N CA  .   CA ? ? C ASP 24  C CA  201 1_555 ? ? ? ? ? ? ? 2.275 ? ? 
metalc55 metalc ?    ? C THR 30  O   ? ? ? 1_555 N CA  .   CA ? ? C THR 26  C CA  201 1_555 ? ? ? ? ? ? ? 2.283 ? ? 
metalc56 metalc ?    ? C GLU 35  OE1 ? ? ? 1_555 N CA  .   CA ? ? C GLU 31  C CA  201 1_555 ? ? ? ? ? ? ? 2.548 ? ? 
metalc57 metalc ?    ? C GLU 35  OE2 ? ? ? 1_555 N CA  .   CA ? ? C GLU 31  C CA  201 1_555 ? ? ? ? ? ? ? 2.382 ? ? 
metalc58 metalc ?    ? C ASP 60  OD1 ? ? ? 1_555 O CA  .   CA ? ? C ASP 56  C CA  202 1_555 ? ? ? ? ? ? ? 2.312 ? ? 
metalc59 metalc ?    ? C ASP 62  OD1 ? ? ? 1_555 O CA  .   CA ? ? C ASP 58  C CA  202 1_555 ? ? ? ? ? ? ? 2.339 ? ? 
metalc60 metalc ?    ? C ASN 64  OD1 ? ? ? 1_555 O CA  .   CA ? ? C ASN 60  C CA  202 1_555 ? ? ? ? ? ? ? 2.281 ? ? 
metalc61 metalc ?    ? C THR 66  O   ? ? ? 1_555 O CA  .   CA ? ? C THR 62  C CA  202 1_555 ? ? ? ? ? ? ? 2.536 ? ? 
metalc62 metalc ?    ? C GLU 71  OE1 ? ? ? 1_555 O CA  .   CA ? ? C GLU 67  C CA  202 1_555 ? ? ? ? ? ? ? 2.637 ? ? 
metalc63 metalc ?    ? C GLU 71  OE2 ? ? ? 1_555 O CA  .   CA ? ? C GLU 67  C CA  202 1_555 ? ? ? ? ? ? ? 2.738 ? ? 
metalc64 metalc ?    ? C ASP 97  OD1 ? ? ? 1_555 P CA  .   CA ? ? C ASP 93  C CA  203 1_555 ? ? ? ? ? ? ? 2.400 ? ? 
metalc65 metalc ?    ? C ASP 99  OD1 ? ? ? 1_555 P CA  .   CA ? ? C ASP 95  C CA  203 1_555 ? ? ? ? ? ? ? 2.289 ? ? 
metalc66 metalc ?    ? C ASN 101 OD1 ? ? ? 1_555 P CA  .   CA ? ? C ASN 97  C CA  203 1_555 ? ? ? ? ? ? ? 2.372 ? ? 
metalc67 metalc ?    ? C TYR 103 O   ? ? ? 1_555 P CA  .   CA ? ? C TYR 99  C CA  203 1_555 ? ? ? ? ? ? ? 2.300 ? ? 
metalc68 metalc ?    ? C GLU 108 OE1 ? ? ? 1_555 P CA  .   CA ? ? C GLU 104 C CA  203 1_555 ? ? ? ? ? ? ? 2.338 ? ? 
metalc69 metalc ?    ? C GLU 108 OE2 ? ? ? 1_555 P CA  .   CA ? ? C GLU 104 C CA  203 1_555 ? ? ? ? ? ? ? 2.732 ? ? 
metalc70 metalc ?    ? C ASP 133 OD1 ? ? ? 1_555 Q CA  .   CA ? ? C ASP 129 C CA  204 1_555 ? ? ? ? ? ? ? 2.302 ? ? 
metalc71 metalc ?    ? C ASP 135 OD1 ? ? ? 1_555 Q CA  .   CA ? ? C ASP 131 C CA  204 1_555 ? ? ? ? ? ? ? 2.368 ? ? 
metalc72 metalc ?    ? C ASP 137 OD1 ? ? ? 1_555 Q CA  .   CA ? ? C ASP 133 C CA  204 1_555 ? ? ? ? ? ? ? 2.396 ? ? 
metalc73 metalc ?    ? C GLN 139 O   ? ? ? 1_555 Q CA  .   CA ? ? C GLN 135 C CA  204 1_555 ? ? ? ? ? ? ? 2.407 ? ? 
metalc74 metalc ?    ? C GLU 144 OE1 ? ? ? 1_555 Q CA  .   CA ? ? C GLU 140 C CA  204 1_555 ? ? ? ? ? ? ? 2.535 ? ? 
metalc75 metalc ?    ? C GLU 144 OE2 ? ? ? 1_555 Q CA  .   CA ? ? C GLU 140 C CA  204 1_555 ? ? ? ? ? ? ? 2.524 ? ? 
metalc76 metalc ?    ? N CA  .   CA  ? ? ? 1_555 U HOH .   O  ? ? C CA  201 C HOH 313 1_555 ? ? ? ? ? ? ? 2.367 ? ? 
metalc77 metalc ?    ? O CA  .   CA  ? ? ? 1_555 U HOH .   O  ? ? C CA  202 C HOH 301 1_555 ? ? ? ? ? ? ? 2.392 ? ? 
metalc78 metalc ?    ? P CA  .   CA  ? ? ? 1_555 U HOH .   O  ? ? C CA  203 C HOH 314 1_555 ? ? ? ? ? ? ? 2.453 ? ? 
metalc79 metalc ?    ? Q CA  .   CA  ? ? ? 1_555 U HOH .   O  ? ? C CA  204 C HOH 308 1_555 ? ? ? ? ? ? ? 2.383 ? ? 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
covale ? ? 
metalc ? ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1   OD1 ? A ASP 24  ? A ASP 20  ? 1_555 CA ? D CA . ? A CA 201 ? 1_555 OD1 ? A ASP 26  ? A ASP 22  ? 1_555 69.6  ? 
2   OD1 ? A ASP 24  ? A ASP 20  ? 1_555 CA ? D CA . ? A CA 201 ? 1_555 OD1 ? A ASP 28  ? A ASP 24  ? 1_555 80.9  ? 
3   OD1 ? A ASP 26  ? A ASP 22  ? 1_555 CA ? D CA . ? A CA 201 ? 1_555 OD1 ? A ASP 28  ? A ASP 24  ? 1_555 76.9  ? 
4   OD1 ? A ASP 24  ? A ASP 20  ? 1_555 CA ? D CA . ? A CA 201 ? 1_555 O   ? A THR 30  ? A THR 26  ? 1_555 71.6  ? 
5   OD1 ? A ASP 26  ? A ASP 22  ? 1_555 CA ? D CA . ? A CA 201 ? 1_555 O   ? A THR 30  ? A THR 26  ? 1_555 135.6 ? 
6   OD1 ? A ASP 28  ? A ASP 24  ? 1_555 CA ? D CA . ? A CA 201 ? 1_555 O   ? A THR 30  ? A THR 26  ? 1_555 76.4  ? 
7   OD1 ? A ASP 24  ? A ASP 20  ? 1_555 CA ? D CA . ? A CA 201 ? 1_555 OE1 ? A GLU 35  ? A GLU 31  ? 1_555 90.8  ? 
8   OD1 ? A ASP 26  ? A ASP 22  ? 1_555 CA ? D CA . ? A CA 201 ? 1_555 OE1 ? A GLU 35  ? A GLU 31  ? 1_555 123.4 ? 
9   OD1 ? A ASP 28  ? A ASP 24  ? 1_555 CA ? D CA . ? A CA 201 ? 1_555 OE1 ? A GLU 35  ? A GLU 31  ? 1_555 153.9 ? 
10  O   ? A THR 30  ? A THR 26  ? 1_555 CA ? D CA . ? A CA 201 ? 1_555 OE1 ? A GLU 35  ? A GLU 31  ? 1_555 77.5  ? 
11  OD1 ? A ASP 24  ? A ASP 20  ? 1_555 CA ? D CA . ? A CA 201 ? 1_555 OE2 ? A GLU 35  ? A GLU 31  ? 1_555 77.3  ? 
12  OD1 ? A ASP 26  ? A ASP 22  ? 1_555 CA ? D CA . ? A CA 201 ? 1_555 OE2 ? A GLU 35  ? A GLU 31  ? 1_555 72.5  ? 
13  OD1 ? A ASP 28  ? A ASP 24  ? 1_555 CA ? D CA . ? A CA 201 ? 1_555 OE2 ? A GLU 35  ? A GLU 31  ? 1_555 147.0 ? 
14  O   ? A THR 30  ? A THR 26  ? 1_555 CA ? D CA . ? A CA 201 ? 1_555 OE2 ? A GLU 35  ? A GLU 31  ? 1_555 118.7 ? 
15  OE1 ? A GLU 35  ? A GLU 31  ? 1_555 CA ? D CA . ? A CA 201 ? 1_555 OE2 ? A GLU 35  ? A GLU 31  ? 1_555 51.2  ? 
16  OD1 ? A ASP 60  ? A ASP 56  ? 1_555 CA ? E CA . ? A CA 202 ? 1_555 OD1 ? A ASP 62  ? A ASP 58  ? 1_555 75.3  ? 
17  OD1 ? A ASP 60  ? A ASP 56  ? 1_555 CA ? E CA . ? A CA 202 ? 1_555 OD1 ? A ASN 64  ? A ASN 60  ? 1_555 81.0  ? 
18  OD1 ? A ASP 62  ? A ASP 58  ? 1_555 CA ? E CA . ? A CA 202 ? 1_555 OD1 ? A ASN 64  ? A ASN 60  ? 1_555 85.1  ? 
19  OD1 ? A ASP 60  ? A ASP 56  ? 1_555 CA ? E CA . ? A CA 202 ? 1_555 O   ? A THR 66  ? A THR 62  ? 1_555 79.7  ? 
20  OD1 ? A ASP 62  ? A ASP 58  ? 1_555 CA ? E CA . ? A CA 202 ? 1_555 O   ? A THR 66  ? A THR 62  ? 1_555 152.4 ? 
21  OD1 ? A ASN 64  ? A ASN 60  ? 1_555 CA ? E CA . ? A CA 202 ? 1_555 O   ? A THR 66  ? A THR 62  ? 1_555 79.6  ? 
22  OD1 ? A ASP 60  ? A ASP 56  ? 1_555 CA ? E CA . ? A CA 202 ? 1_555 OE1 ? A GLU 71  ? A GLU 67  ? 1_555 95.8  ? 
23  OD1 ? A ASP 62  ? A ASP 58  ? 1_555 CA ? E CA . ? A CA 202 ? 1_555 OE1 ? A GLU 71  ? A GLU 67  ? 1_555 112.7 ? 
24  OD1 ? A ASN 64  ? A ASN 60  ? 1_555 CA ? E CA . ? A CA 202 ? 1_555 OE1 ? A GLU 71  ? A GLU 67  ? 1_555 160.6 ? 
25  O   ? A THR 66  ? A THR 62  ? 1_555 CA ? E CA . ? A CA 202 ? 1_555 OE1 ? A GLU 71  ? A GLU 67  ? 1_555 81.0  ? 
26  OD1 ? A ASP 60  ? A ASP 56  ? 1_555 CA ? E CA . ? A CA 202 ? 1_555 OE2 ? A GLU 71  ? A GLU 67  ? 1_555 99.6  ? 
27  OD1 ? A ASP 62  ? A ASP 58  ? 1_555 CA ? E CA . ? A CA 202 ? 1_555 OE2 ? A GLU 71  ? A GLU 67  ? 1_555 64.5  ? 
28  OD1 ? A ASN 64  ? A ASN 60  ? 1_555 CA ? E CA . ? A CA 202 ? 1_555 OE2 ? A GLU 71  ? A GLU 67  ? 1_555 148.0 ? 
29  O   ? A THR 66  ? A THR 62  ? 1_555 CA ? E CA . ? A CA 202 ? 1_555 OE2 ? A GLU 71  ? A GLU 67  ? 1_555 132.2 ? 
30  OE1 ? A GLU 71  ? A GLU 67  ? 1_555 CA ? E CA . ? A CA 202 ? 1_555 OE2 ? A GLU 71  ? A GLU 67  ? 1_555 51.4  ? 
31  OD1 ? A ASP 97  ? A ASP 93  ? 1_555 CA ? F CA . ? A CA 203 ? 1_555 OD1 ? A ASP 99  ? A ASP 95  ? 1_555 78.4  ? 
32  OD1 ? A ASP 97  ? A ASP 93  ? 1_555 CA ? F CA . ? A CA 203 ? 1_555 OD1 ? A ASN 101 ? A ASN 97  ? 1_555 81.8  ? 
33  OD1 ? A ASP 99  ? A ASP 95  ? 1_555 CA ? F CA . ? A CA 203 ? 1_555 OD1 ? A ASN 101 ? A ASN 97  ? 1_555 78.5  ? 
34  OD1 ? A ASP 97  ? A ASP 93  ? 1_555 CA ? F CA . ? A CA 203 ? 1_555 O   ? A TYR 103 ? A TYR 99  ? 1_555 93.1  ? 
35  OD1 ? A ASP 99  ? A ASP 95  ? 1_555 CA ? F CA . ? A CA 203 ? 1_555 O   ? A TYR 103 ? A TYR 99  ? 1_555 160.4 ? 
36  OD1 ? A ASN 101 ? A ASN 97  ? 1_555 CA ? F CA . ? A CA 203 ? 1_555 O   ? A TYR 103 ? A TYR 99  ? 1_555 82.8  ? 
37  OD1 ? A ASP 97  ? A ASP 93  ? 1_555 CA ? F CA . ? A CA 203 ? 1_555 OE1 ? A GLU 108 ? A GLU 104 ? 1_555 103.4 ? 
38  OD1 ? A ASP 99  ? A ASP 95  ? 1_555 CA ? F CA . ? A CA 203 ? 1_555 OE1 ? A GLU 108 ? A GLU 104 ? 1_555 119.0 ? 
39  OD1 ? A ASN 101 ? A ASN 97  ? 1_555 CA ? F CA . ? A CA 203 ? 1_555 OE1 ? A GLU 108 ? A GLU 104 ? 1_555 162.2 ? 
40  O   ? A TYR 103 ? A TYR 99  ? 1_555 CA ? F CA . ? A CA 203 ? 1_555 OE1 ? A GLU 108 ? A GLU 104 ? 1_555 79.9  ? 
41  OD1 ? A ASP 97  ? A ASP 93  ? 1_555 CA ? F CA . ? A CA 203 ? 1_555 OE2 ? A GLU 108 ? A GLU 104 ? 1_555 97.5  ? 
42  OD1 ? A ASP 99  ? A ASP 95  ? 1_555 CA ? F CA . ? A CA 203 ? 1_555 OE2 ? A GLU 108 ? A GLU 104 ? 1_555 69.2  ? 
43  OD1 ? A ASN 101 ? A ASN 97  ? 1_555 CA ? F CA . ? A CA 203 ? 1_555 OE2 ? A GLU 108 ? A GLU 104 ? 1_555 147.1 ? 
44  O   ? A TYR 103 ? A TYR 99  ? 1_555 CA ? F CA . ? A CA 203 ? 1_555 OE2 ? A GLU 108 ? A GLU 104 ? 1_555 129.9 ? 
45  OE1 ? A GLU 108 ? A GLU 104 ? 1_555 CA ? F CA . ? A CA 203 ? 1_555 OE2 ? A GLU 108 ? A GLU 104 ? 1_555 50.0  ? 
46  OD1 ? A ASP 97  ? A ASP 93  ? 1_555 CA ? F CA . ? A CA 203 ? 1_555 O   ? S HOH .   ? A HOH 310 ? 1_555 164.5 ? 
47  OD1 ? A ASP 99  ? A ASP 95  ? 1_555 CA ? F CA . ? A CA 203 ? 1_555 O   ? S HOH .   ? A HOH 310 ? 1_555 86.4  ? 
48  OD1 ? A ASN 101 ? A ASN 97  ? 1_555 CA ? F CA . ? A CA 203 ? 1_555 O   ? S HOH .   ? A HOH 310 ? 1_555 98.5  ? 
49  O   ? A TYR 103 ? A TYR 99  ? 1_555 CA ? F CA . ? A CA 203 ? 1_555 O   ? S HOH .   ? A HOH 310 ? 1_555 102.4 ? 
50  OE1 ? A GLU 108 ? A GLU 104 ? 1_555 CA ? F CA . ? A CA 203 ? 1_555 O   ? S HOH .   ? A HOH 310 ? 1_555 81.2  ? 
51  OE2 ? A GLU 108 ? A GLU 104 ? 1_555 CA ? F CA . ? A CA 203 ? 1_555 O   ? S HOH .   ? A HOH 310 ? 1_555 73.8  ? 
52  OD1 ? A ASP 133 ? A ASP 129 ? 1_555 CA ? G CA . ? A CA 204 ? 1_555 OD1 ? A ASP 135 ? A ASP 131 ? 1_555 79.4  ? 
53  OD1 ? A ASP 133 ? A ASP 129 ? 1_555 CA ? G CA . ? A CA 204 ? 1_555 OD1 ? A ASP 137 ? A ASP 133 ? 1_555 93.2  ? 
54  OD1 ? A ASP 135 ? A ASP 131 ? 1_555 CA ? G CA . ? A CA 204 ? 1_555 OD1 ? A ASP 137 ? A ASP 133 ? 1_555 79.3  ? 
55  OD1 ? A ASP 133 ? A ASP 129 ? 1_555 CA ? G CA . ? A CA 204 ? 1_555 O   ? A GLN 139 ? A GLN 135 ? 1_555 83.3  ? 
56  OD1 ? A ASP 135 ? A ASP 131 ? 1_555 CA ? G CA . ? A CA 204 ? 1_555 O   ? A GLN 139 ? A GLN 135 ? 1_555 150.1 ? 
57  OD1 ? A ASP 137 ? A ASP 133 ? 1_555 CA ? G CA . ? A CA 204 ? 1_555 O   ? A GLN 139 ? A GLN 135 ? 1_555 77.6  ? 
58  OD1 ? A ASP 133 ? A ASP 129 ? 1_555 CA ? G CA . ? A CA 204 ? 1_555 OE1 ? A GLU 144 ? A GLU 140 ? 1_555 107.3 ? 
59  OD1 ? A ASP 135 ? A ASP 131 ? 1_555 CA ? G CA . ? A CA 204 ? 1_555 OE1 ? A GLU 144 ? A GLU 140 ? 1_555 124.5 ? 
60  OD1 ? A ASP 137 ? A ASP 133 ? 1_555 CA ? G CA . ? A CA 204 ? 1_555 OE1 ? A GLU 144 ? A GLU 140 ? 1_555 150.4 ? 
61  O   ? A GLN 139 ? A GLN 135 ? 1_555 CA ? G CA . ? A CA 204 ? 1_555 OE1 ? A GLU 144 ? A GLU 140 ? 1_555 83.9  ? 
62  OD1 ? A ASP 133 ? A ASP 129 ? 1_555 CA ? G CA . ? A CA 204 ? 1_555 OE2 ? A GLU 144 ? A GLU 140 ? 1_555 74.6  ? 
63  OD1 ? A ASP 135 ? A ASP 131 ? 1_555 CA ? G CA . ? A CA 204 ? 1_555 OE2 ? A GLU 144 ? A GLU 140 ? 1_555 80.0  ? 
64  OD1 ? A ASP 137 ? A ASP 133 ? 1_555 CA ? G CA . ? A CA 204 ? 1_555 OE2 ? A GLU 144 ? A GLU 140 ? 1_555 157.6 ? 
65  O   ? A GLN 139 ? A GLN 135 ? 1_555 CA ? G CA . ? A CA 204 ? 1_555 OE2 ? A GLU 144 ? A GLU 140 ? 1_555 118.4 ? 
66  OE1 ? A GLU 144 ? A GLU 140 ? 1_555 CA ? G CA . ? A CA 204 ? 1_555 OE2 ? A GLU 144 ? A GLU 140 ? 1_555 51.8  ? 
67  OD1 ? A ASP 133 ? A ASP 129 ? 1_555 CA ? G CA . ? A CA 204 ? 1_555 O   ? S HOH .   ? A HOH 312 ? 1_555 168.9 ? 
68  OD1 ? A ASP 135 ? A ASP 131 ? 1_555 CA ? G CA . ? A CA 204 ? 1_555 O   ? S HOH .   ? A HOH 312 ? 1_555 89.9  ? 
69  OD1 ? A ASP 137 ? A ASP 133 ? 1_555 CA ? G CA . ? A CA 204 ? 1_555 O   ? S HOH .   ? A HOH 312 ? 1_555 81.6  ? 
70  O   ? A GLN 139 ? A GLN 135 ? 1_555 CA ? G CA . ? A CA 204 ? 1_555 O   ? S HOH .   ? A HOH 312 ? 1_555 105.0 ? 
71  OE1 ? A GLU 144 ? A GLU 140 ? 1_555 CA ? G CA . ? A CA 204 ? 1_555 O   ? S HOH .   ? A HOH 312 ? 1_555 81.3  ? 
72  OE2 ? A GLU 144 ? A GLU 140 ? 1_555 CA ? G CA . ? A CA 204 ? 1_555 O   ? S HOH .   ? A HOH 312 ? 1_555 106.9 ? 
73  OD1 ? B ASP 24  ? B ASP 20  ? 1_555 CA ? I CA . ? B CA 201 ? 1_555 OD1 ? B ASP 26  ? B ASP 22  ? 1_555 70.6  ? 
74  OD1 ? B ASP 24  ? B ASP 20  ? 1_555 CA ? I CA . ? B CA 201 ? 1_555 OD1 ? B ASP 28  ? B ASP 24  ? 1_555 82.5  ? 
75  OD1 ? B ASP 26  ? B ASP 22  ? 1_555 CA ? I CA . ? B CA 201 ? 1_555 OD1 ? B ASP 28  ? B ASP 24  ? 1_555 78.3  ? 
76  OD1 ? B ASP 24  ? B ASP 20  ? 1_555 CA ? I CA . ? B CA 201 ? 1_555 O   ? B THR 30  ? B THR 26  ? 1_555 76.8  ? 
77  OD1 ? B ASP 26  ? B ASP 22  ? 1_555 CA ? I CA . ? B CA 201 ? 1_555 O   ? B THR 30  ? B THR 26  ? 1_555 142.9 ? 
78  OD1 ? B ASP 28  ? B ASP 24  ? 1_555 CA ? I CA . ? B CA 201 ? 1_555 O   ? B THR 30  ? B THR 26  ? 1_555 80.4  ? 
79  OD1 ? B ASP 24  ? B ASP 20  ? 1_555 CA ? I CA . ? B CA 201 ? 1_555 OE1 ? B GLU 35  ? B GLU 31  ? 1_555 94.5  ? 
80  OD1 ? B ASP 26  ? B ASP 22  ? 1_555 CA ? I CA . ? B CA 201 ? 1_555 OE1 ? B GLU 35  ? B GLU 31  ? 1_555 120.7 ? 
81  OD1 ? B ASP 28  ? B ASP 24  ? 1_555 CA ? I CA . ? B CA 201 ? 1_555 OE1 ? B GLU 35  ? B GLU 31  ? 1_555 158.8 ? 
82  O   ? B THR 30  ? B THR 26  ? 1_555 CA ? I CA . ? B CA 201 ? 1_555 OE1 ? B GLU 35  ? B GLU 31  ? 1_555 78.5  ? 
83  OD1 ? B ASP 24  ? B ASP 20  ? 1_555 CA ? I CA . ? B CA 201 ? 1_555 OE2 ? B GLU 35  ? B GLU 31  ? 1_555 83.7  ? 
84  OD1 ? B ASP 26  ? B ASP 22  ? 1_555 CA ? I CA . ? B CA 201 ? 1_555 OE2 ? B GLU 35  ? B GLU 31  ? 1_555 73.2  ? 
85  OD1 ? B ASP 28  ? B ASP 24  ? 1_555 CA ? I CA . ? B CA 201 ? 1_555 OE2 ? B GLU 35  ? B GLU 31  ? 1_555 151.1 ? 
86  O   ? B THR 30  ? B THR 26  ? 1_555 CA ? I CA . ? B CA 201 ? 1_555 OE2 ? B GLU 35  ? B GLU 31  ? 1_555 120.7 ? 
87  OE1 ? B GLU 35  ? B GLU 31  ? 1_555 CA ? I CA . ? B CA 201 ? 1_555 OE2 ? B GLU 35  ? B GLU 31  ? 1_555 47.8  ? 
88  OD1 ? B ASP 60  ? B ASP 56  ? 1_555 CA ? J CA . ? B CA 202 ? 1_555 OD1 ? B ASP 62  ? B ASP 58  ? 1_555 80.6  ? 
89  OD1 ? B ASP 60  ? B ASP 56  ? 1_555 CA ? J CA . ? B CA 202 ? 1_555 OD1 ? B ASN 64  ? B ASN 60  ? 1_555 78.7  ? 
90  OD1 ? B ASP 62  ? B ASP 58  ? 1_555 CA ? J CA . ? B CA 202 ? 1_555 OD1 ? B ASN 64  ? B ASN 60  ? 1_555 78.4  ? 
91  OD1 ? B ASP 60  ? B ASP 56  ? 1_555 CA ? J CA . ? B CA 202 ? 1_555 O   ? B THR 66  ? B THR 62  ? 1_555 88.4  ? 
92  OD1 ? B ASP 62  ? B ASP 58  ? 1_555 CA ? J CA . ? B CA 202 ? 1_555 O   ? B THR 66  ? B THR 62  ? 1_555 154.0 ? 
93  OD1 ? B ASN 64  ? B ASN 60  ? 1_555 CA ? J CA . ? B CA 202 ? 1_555 O   ? B THR 66  ? B THR 62  ? 1_555 76.4  ? 
94  OD1 ? B ASP 60  ? B ASP 56  ? 1_555 CA ? J CA . ? B CA 202 ? 1_555 OE1 ? B GLU 71  ? B GLU 67  ? 1_555 102.1 ? 
95  OD1 ? B ASP 62  ? B ASP 58  ? 1_555 CA ? J CA . ? B CA 202 ? 1_555 OE1 ? B GLU 71  ? B GLU 67  ? 1_555 124.8 ? 
96  OD1 ? B ASN 64  ? B ASN 60  ? 1_555 CA ? J CA . ? B CA 202 ? 1_555 OE1 ? B GLU 71  ? B GLU 67  ? 1_555 156.7 ? 
97  O   ? B THR 66  ? B THR 62  ? 1_555 CA ? J CA . ? B CA 202 ? 1_555 OE1 ? B GLU 71  ? B GLU 67  ? 1_555 80.3  ? 
98  OD1 ? B ASP 60  ? B ASP 56  ? 1_555 CA ? J CA . ? B CA 202 ? 1_555 OE2 ? B GLU 71  ? B GLU 67  ? 1_555 72.8  ? 
99  OD1 ? B ASP 62  ? B ASP 58  ? 1_555 CA ? J CA . ? B CA 202 ? 1_555 OE2 ? B GLU 71  ? B GLU 67  ? 1_555 76.5  ? 
100 OD1 ? B ASN 64  ? B ASN 60  ? 1_555 CA ? J CA . ? B CA 202 ? 1_555 OE2 ? B GLU 71  ? B GLU 67  ? 1_555 144.5 ? 
101 O   ? B THR 66  ? B THR 62  ? 1_555 CA ? J CA . ? B CA 202 ? 1_555 OE2 ? B GLU 71  ? B GLU 67  ? 1_555 122.5 ? 
102 OE1 ? B GLU 71  ? B GLU 67  ? 1_555 CA ? J CA . ? B CA 202 ? 1_555 OE2 ? B GLU 71  ? B GLU 67  ? 1_555 53.4  ? 
103 OD1 ? B ASP 97  ? B ASP 93  ? 1_555 CA ? K CA . ? B CA 203 ? 1_555 OD1 ? B ASP 99  ? B ASP 95  ? 1_555 73.4  ? 
104 OD1 ? B ASP 97  ? B ASP 93  ? 1_555 CA ? K CA . ? B CA 203 ? 1_555 OD1 ? B ASN 101 ? B ASN 97  ? 1_555 82.7  ? 
105 OD1 ? B ASP 99  ? B ASP 95  ? 1_555 CA ? K CA . ? B CA 203 ? 1_555 OD1 ? B ASN 101 ? B ASN 97  ? 1_555 80.4  ? 
106 OD1 ? B ASP 97  ? B ASP 93  ? 1_555 CA ? K CA . ? B CA 203 ? 1_555 O   ? B TYR 103 ? B TYR 99  ? 1_555 92.7  ? 
107 OD1 ? B ASP 99  ? B ASP 95  ? 1_555 CA ? K CA . ? B CA 203 ? 1_555 O   ? B TYR 103 ? B TYR 99  ? 1_555 158.2 ? 
108 OD1 ? B ASN 101 ? B ASN 97  ? 1_555 CA ? K CA . ? B CA 203 ? 1_555 O   ? B TYR 103 ? B TYR 99  ? 1_555 81.1  ? 
109 OD1 ? B ASP 97  ? B ASP 93  ? 1_555 CA ? K CA . ? B CA 203 ? 1_555 OE1 ? B GLU 108 ? B GLU 104 ? 1_555 97.1  ? 
110 OD1 ? B ASP 99  ? B ASP 95  ? 1_555 CA ? K CA . ? B CA 203 ? 1_555 OE1 ? B GLU 108 ? B GLU 104 ? 1_555 121.5 ? 
111 OD1 ? B ASN 101 ? B ASN 97  ? 1_555 CA ? K CA . ? B CA 203 ? 1_555 OE1 ? B GLU 108 ? B GLU 104 ? 1_555 157.2 ? 
112 O   ? B TYR 103 ? B TYR 99  ? 1_555 CA ? K CA . ? B CA 203 ? 1_555 OE1 ? B GLU 108 ? B GLU 104 ? 1_555 76.1  ? 
113 OD1 ? B ASP 97  ? B ASP 93  ? 1_555 CA ? K CA . ? B CA 203 ? 1_555 OE2 ? B GLU 108 ? B GLU 104 ? 1_555 84.1  ? 
114 OD1 ? B ASP 99  ? B ASP 95  ? 1_555 CA ? K CA . ? B CA 203 ? 1_555 OE2 ? B GLU 108 ? B GLU 104 ? 1_555 72.1  ? 
115 OD1 ? B ASN 101 ? B ASN 97  ? 1_555 CA ? K CA . ? B CA 203 ? 1_555 OE2 ? B GLU 108 ? B GLU 104 ? 1_555 151.9 ? 
116 O   ? B TYR 103 ? B TYR 99  ? 1_555 CA ? K CA . ? B CA 203 ? 1_555 OE2 ? B GLU 108 ? B GLU 104 ? 1_555 124.2 ? 
117 OE1 ? B GLU 108 ? B GLU 104 ? 1_555 CA ? K CA . ? B CA 203 ? 1_555 OE2 ? B GLU 108 ? B GLU 104 ? 1_555 49.4  ? 
118 OD1 ? B ASP 133 ? B ASP 129 ? 1_555 CA ? L CA . ? B CA 204 ? 1_555 OD1 ? B ASP 135 ? B ASP 131 ? 1_555 74.1  ? 
119 OD1 ? B ASP 133 ? B ASP 129 ? 1_555 CA ? L CA . ? B CA 204 ? 1_555 OD1 ? B ASP 137 ? B ASP 133 ? 1_555 91.7  ? 
120 OD1 ? B ASP 135 ? B ASP 131 ? 1_555 CA ? L CA . ? B CA 204 ? 1_555 OD1 ? B ASP 137 ? B ASP 133 ? 1_555 72.4  ? 
121 OD1 ? B ASP 133 ? B ASP 129 ? 1_555 CA ? L CA . ? B CA 204 ? 1_555 O   ? B GLN 139 ? B GLN 135 ? 1_555 91.0  ? 
122 OD1 ? B ASP 135 ? B ASP 131 ? 1_555 CA ? L CA . ? B CA 204 ? 1_555 O   ? B GLN 139 ? B GLN 135 ? 1_555 146.7 ? 
123 OD1 ? B ASP 137 ? B ASP 133 ? 1_555 CA ? L CA . ? B CA 204 ? 1_555 O   ? B GLN 139 ? B GLN 135 ? 1_555 78.6  ? 
124 OD1 ? B ASP 133 ? B ASP 129 ? 1_555 CA ? L CA . ? B CA 204 ? 1_555 OE1 ? B GLU 144 ? B GLU 140 ? 1_555 105.6 ? 
125 OD1 ? B ASP 135 ? B ASP 131 ? 1_555 CA ? L CA . ? B CA 204 ? 1_555 OE1 ? B GLU 144 ? B GLU 140 ? 1_555 131.6 ? 
126 OD1 ? B ASP 137 ? B ASP 133 ? 1_555 CA ? L CA . ? B CA 204 ? 1_555 OE1 ? B GLU 144 ? B GLU 140 ? 1_555 153.2 ? 
127 O   ? B GLN 139 ? B GLN 135 ? 1_555 CA ? L CA . ? B CA 204 ? 1_555 OE1 ? B GLU 144 ? B GLU 140 ? 1_555 80.7  ? 
128 OD1 ? B ASP 133 ? B ASP 129 ? 1_555 CA ? L CA . ? B CA 204 ? 1_555 OE2 ? B GLU 144 ? B GLU 140 ? 1_555 78.5  ? 
129 OD1 ? B ASP 135 ? B ASP 131 ? 1_555 CA ? L CA . ? B CA 204 ? 1_555 OE2 ? B GLU 144 ? B GLU 140 ? 1_555 80.5  ? 
130 OD1 ? B ASP 137 ? B ASP 133 ? 1_555 CA ? L CA . ? B CA 204 ? 1_555 OE2 ? B GLU 144 ? B GLU 140 ? 1_555 152.9 ? 
131 O   ? B GLN 139 ? B GLN 135 ? 1_555 CA ? L CA . ? B CA 204 ? 1_555 OE2 ? B GLU 144 ? B GLU 140 ? 1_555 126.3 ? 
132 OE1 ? B GLU 144 ? B GLU 140 ? 1_555 CA ? L CA . ? B CA 204 ? 1_555 OE2 ? B GLU 144 ? B GLU 140 ? 1_555 53.2  ? 
133 OD1 ? B ASP 133 ? B ASP 129 ? 1_555 CA ? L CA . ? B CA 204 ? 1_555 O   ? T HOH .   ? B HOH 310 ? 1_555 160.8 ? 
134 OD1 ? B ASP 135 ? B ASP 131 ? 1_555 CA ? L CA . ? B CA 204 ? 1_555 O   ? T HOH .   ? B HOH 310 ? 1_555 87.1  ? 
135 OD1 ? B ASP 137 ? B ASP 133 ? 1_555 CA ? L CA . ? B CA 204 ? 1_555 O   ? T HOH .   ? B HOH 310 ? 1_555 86.1  ? 
136 O   ? B GLN 139 ? B GLN 135 ? 1_555 CA ? L CA . ? B CA 204 ? 1_555 O   ? T HOH .   ? B HOH 310 ? 1_555 107.2 ? 
137 OE1 ? B GLU 144 ? B GLU 140 ? 1_555 CA ? L CA . ? B CA 204 ? 1_555 O   ? T HOH .   ? B HOH 310 ? 1_555 83.9  ? 
138 OE2 ? B GLU 144 ? B GLU 140 ? 1_555 CA ? L CA . ? B CA 204 ? 1_555 O   ? T HOH .   ? B HOH 310 ? 1_555 95.0  ? 
139 OD1 ? C ASP 24  ? C ASP 20  ? 1_555 CA ? N CA . ? C CA 201 ? 1_555 OD1 ? C ASP 26  ? C ASP 22  ? 1_555 75.5  ? 
140 OD1 ? C ASP 24  ? C ASP 20  ? 1_555 CA ? N CA . ? C CA 201 ? 1_555 OD1 ? C ASP 28  ? C ASP 24  ? 1_555 78.0  ? 
141 OD1 ? C ASP 26  ? C ASP 22  ? 1_555 CA ? N CA . ? C CA 201 ? 1_555 OD1 ? C ASP 28  ? C ASP 24  ? 1_555 77.9  ? 
142 OD1 ? C ASP 24  ? C ASP 20  ? 1_555 CA ? N CA . ? C CA 201 ? 1_555 O   ? C THR 30  ? C THR 26  ? 1_555 79.4  ? 
143 OD1 ? C ASP 26  ? C ASP 22  ? 1_555 CA ? N CA . ? C CA 201 ? 1_555 O   ? C THR 30  ? C THR 26  ? 1_555 148.6 ? 
144 OD1 ? C ASP 28  ? C ASP 24  ? 1_555 CA ? N CA . ? C CA 201 ? 1_555 O   ? C THR 30  ? C THR 26  ? 1_555 78.7  ? 
145 OD1 ? C ASP 24  ? C ASP 20  ? 1_555 CA ? N CA . ? C CA 201 ? 1_555 OE1 ? C GLU 35  ? C GLU 31  ? 1_555 104.3 ? 
146 OD1 ? C ASP 26  ? C ASP 22  ? 1_555 CA ? N CA . ? C CA 201 ? 1_555 OE1 ? C GLU 35  ? C GLU 31  ? 1_555 126.1 ? 
147 OD1 ? C ASP 28  ? C ASP 24  ? 1_555 CA ? N CA . ? C CA 201 ? 1_555 OE1 ? C GLU 35  ? C GLU 31  ? 1_555 156.0 ? 
148 O   ? C THR 30  ? C THR 26  ? 1_555 CA ? N CA . ? C CA 201 ? 1_555 OE1 ? C GLU 35  ? C GLU 31  ? 1_555 78.3  ? 
149 OD1 ? C ASP 24  ? C ASP 20  ? 1_555 CA ? N CA . ? C CA 201 ? 1_555 OE2 ? C GLU 35  ? C GLU 31  ? 1_555 96.3  ? 
150 OD1 ? C ASP 26  ? C ASP 22  ? 1_555 CA ? N CA . ? C CA 201 ? 1_555 OE2 ? C GLU 35  ? C GLU 31  ? 1_555 73.4  ? 
151 OD1 ? C ASP 28  ? C ASP 24  ? 1_555 CA ? N CA . ? C CA 201 ? 1_555 OE2 ? C GLU 35  ? C GLU 31  ? 1_555 151.2 ? 
152 O   ? C THR 30  ? C THR 26  ? 1_555 CA ? N CA . ? C CA 201 ? 1_555 OE2 ? C GLU 35  ? C GLU 31  ? 1_555 128.5 ? 
153 OE1 ? C GLU 35  ? C GLU 31  ? 1_555 CA ? N CA . ? C CA 201 ? 1_555 OE2 ? C GLU 35  ? C GLU 31  ? 1_555 52.8  ? 
154 OD1 ? C ASP 24  ? C ASP 20  ? 1_555 CA ? N CA . ? C CA 201 ? 1_555 O   ? U HOH .   ? C HOH 313 ? 1_555 171.1 ? 
155 OD1 ? C ASP 26  ? C ASP 22  ? 1_555 CA ? N CA . ? C CA 201 ? 1_555 O   ? U HOH .   ? C HOH 313 ? 1_555 96.4  ? 
156 OD1 ? C ASP 28  ? C ASP 24  ? 1_555 CA ? N CA . ? C CA 201 ? 1_555 O   ? U HOH .   ? C HOH 313 ? 1_555 96.8  ? 
157 O   ? C THR 30  ? C THR 26  ? 1_555 CA ? N CA . ? C CA 201 ? 1_555 O   ? U HOH .   ? C HOH 313 ? 1_555 106.9 ? 
158 OE1 ? C GLU 35  ? C GLU 31  ? 1_555 CA ? N CA . ? C CA 201 ? 1_555 O   ? U HOH .   ? C HOH 313 ? 1_555 83.4  ? 
159 OE2 ? C GLU 35  ? C GLU 31  ? 1_555 CA ? N CA . ? C CA 201 ? 1_555 O   ? U HOH .   ? C HOH 313 ? 1_555 84.7  ? 
160 OD1 ? C ASP 60  ? C ASP 56  ? 1_555 CA ? O CA . ? C CA 202 ? 1_555 OD1 ? C ASP 62  ? C ASP 58  ? 1_555 73.4  ? 
161 OD1 ? C ASP 60  ? C ASP 56  ? 1_555 CA ? O CA . ? C CA 202 ? 1_555 OD1 ? C ASN 64  ? C ASN 60  ? 1_555 82.0  ? 
162 OD1 ? C ASP 62  ? C ASP 58  ? 1_555 CA ? O CA . ? C CA 202 ? 1_555 OD1 ? C ASN 64  ? C ASN 60  ? 1_555 81.0  ? 
163 OD1 ? C ASP 60  ? C ASP 56  ? 1_555 CA ? O CA . ? C CA 202 ? 1_555 O   ? C THR 66  ? C THR 62  ? 1_555 72.7  ? 
164 OD1 ? C ASP 62  ? C ASP 58  ? 1_555 CA ? O CA . ? C CA 202 ? 1_555 O   ? C THR 66  ? C THR 62  ? 1_555 140.6 ? 
165 OD1 ? C ASN 64  ? C ASN 60  ? 1_555 CA ? O CA . ? C CA 202 ? 1_555 O   ? C THR 66  ? C THR 62  ? 1_555 74.9  ? 
166 OD1 ? C ASP 60  ? C ASP 56  ? 1_555 CA ? O CA . ? C CA 202 ? 1_555 OE1 ? C GLU 71  ? C GLU 67  ? 1_555 89.9  ? 
167 OD1 ? C ASP 62  ? C ASP 58  ? 1_555 CA ? O CA . ? C CA 202 ? 1_555 OE1 ? C GLU 71  ? C GLU 67  ? 1_555 117.7 ? 
168 OD1 ? C ASN 64  ? C ASN 60  ? 1_555 CA ? O CA . ? C CA 202 ? 1_555 OE1 ? C GLU 71  ? C GLU 67  ? 1_555 156.6 ? 
169 O   ? C THR 66  ? C THR 62  ? 1_555 CA ? O CA . ? C CA 202 ? 1_555 OE1 ? C GLU 71  ? C GLU 67  ? 1_555 81.8  ? 
170 OD1 ? C ASP 60  ? C ASP 56  ? 1_555 CA ? O CA . ? C CA 202 ? 1_555 OE2 ? C GLU 71  ? C GLU 67  ? 1_555 87.9  ? 
171 OD1 ? C ASP 62  ? C ASP 58  ? 1_555 CA ? O CA . ? C CA 202 ? 1_555 OE2 ? C GLU 71  ? C GLU 67  ? 1_555 71.1  ? 
172 OD1 ? C ASN 64  ? C ASN 60  ? 1_555 CA ? O CA . ? C CA 202 ? 1_555 OE2 ? C GLU 71  ? C GLU 67  ? 1_555 152.0 ? 
173 O   ? C THR 66  ? C THR 62  ? 1_555 CA ? O CA . ? C CA 202 ? 1_555 OE2 ? C GLU 71  ? C GLU 67  ? 1_555 126.6 ? 
174 OE1 ? C GLU 71  ? C GLU 67  ? 1_555 CA ? O CA . ? C CA 202 ? 1_555 OE2 ? C GLU 71  ? C GLU 67  ? 1_555 48.2  ? 
175 OD1 ? C ASP 60  ? C ASP 56  ? 1_555 CA ? O CA . ? C CA 202 ? 1_555 O   ? U HOH .   ? C HOH 301 ? 1_555 174.7 ? 
176 OD1 ? C ASP 62  ? C ASP 58  ? 1_555 CA ? O CA . ? C CA 202 ? 1_555 O   ? U HOH .   ? C HOH 301 ? 1_555 101.4 ? 
177 OD1 ? C ASN 64  ? C ASN 60  ? 1_555 CA ? O CA . ? C CA 202 ? 1_555 O   ? U HOH .   ? C HOH 301 ? 1_555 95.9  ? 
178 O   ? C THR 66  ? C THR 62  ? 1_555 CA ? O CA . ? C CA 202 ? 1_555 O   ? U HOH .   ? C HOH 301 ? 1_555 111.6 ? 
179 OE1 ? C GLU 71  ? C GLU 67  ? 1_555 CA ? O CA . ? C CA 202 ? 1_555 O   ? U HOH .   ? C HOH 301 ? 1_555 93.8  ? 
180 OE2 ? C GLU 71  ? C GLU 67  ? 1_555 CA ? O CA . ? C CA 202 ? 1_555 O   ? U HOH .   ? C HOH 301 ? 1_555 91.8  ? 
181 OD1 ? C ASP 97  ? C ASP 93  ? 1_555 CA ? P CA . ? C CA 203 ? 1_555 OD1 ? C ASP 99  ? C ASP 95  ? 1_555 75.6  ? 
182 OD1 ? C ASP 97  ? C ASP 93  ? 1_555 CA ? P CA . ? C CA 203 ? 1_555 OD1 ? C ASN 101 ? C ASN 97  ? 1_555 81.2  ? 
183 OD1 ? C ASP 99  ? C ASP 95  ? 1_555 CA ? P CA . ? C CA 203 ? 1_555 OD1 ? C ASN 101 ? C ASN 97  ? 1_555 79.2  ? 
184 OD1 ? C ASP 97  ? C ASP 93  ? 1_555 CA ? P CA . ? C CA 203 ? 1_555 O   ? C TYR 103 ? C TYR 99  ? 1_555 95.4  ? 
185 OD1 ? C ASP 99  ? C ASP 95  ? 1_555 CA ? P CA . ? C CA 203 ? 1_555 O   ? C TYR 103 ? C TYR 99  ? 1_555 158.8 ? 
186 OD1 ? C ASN 101 ? C ASN 97  ? 1_555 CA ? P CA . ? C CA 203 ? 1_555 O   ? C TYR 103 ? C TYR 99  ? 1_555 80.6  ? 
187 OD1 ? C ASP 97  ? C ASP 93  ? 1_555 CA ? P CA . ? C CA 203 ? 1_555 OE1 ? C GLU 108 ? C GLU 104 ? 1_555 113.5 ? 
188 OD1 ? C ASP 99  ? C ASP 95  ? 1_555 CA ? P CA . ? C CA 203 ? 1_555 OE1 ? C GLU 108 ? C GLU 104 ? 1_555 120.7 ? 
189 OD1 ? C ASN 101 ? C ASN 97  ? 1_555 CA ? P CA . ? C CA 203 ? 1_555 OE1 ? C GLU 108 ? C GLU 104 ? 1_555 156.9 ? 
190 O   ? C TYR 103 ? C TYR 99  ? 1_555 CA ? P CA . ? C CA 203 ? 1_555 OE1 ? C GLU 108 ? C GLU 104 ? 1_555 80.4  ? 
191 OD1 ? C ASP 97  ? C ASP 93  ? 1_555 CA ? P CA . ? C CA 203 ? 1_555 OE2 ? C GLU 108 ? C GLU 104 ? 1_555 92.6  ? 
192 OD1 ? C ASP 99  ? C ASP 95  ? 1_555 CA ? P CA . ? C CA 203 ? 1_555 OE2 ? C GLU 108 ? C GLU 104 ? 1_555 71.3  ? 
193 OD1 ? C ASN 101 ? C ASN 97  ? 1_555 CA ? P CA . ? C CA 203 ? 1_555 OE2 ? C GLU 108 ? C GLU 104 ? 1_555 150.4 ? 
194 O   ? C TYR 103 ? C TYR 99  ? 1_555 CA ? P CA . ? C CA 203 ? 1_555 OE2 ? C GLU 108 ? C GLU 104 ? 1_555 129.0 ? 
195 OE1 ? C GLU 108 ? C GLU 104 ? 1_555 CA ? P CA . ? C CA 203 ? 1_555 OE2 ? C GLU 108 ? C GLU 104 ? 1_555 50.6  ? 
196 OD1 ? C ASP 97  ? C ASP 93  ? 1_555 CA ? P CA . ? C CA 203 ? 1_555 O   ? U HOH .   ? C HOH 314 ? 1_555 161.5 ? 
197 OD1 ? C ASP 99  ? C ASP 95  ? 1_555 CA ? P CA . ? C CA 203 ? 1_555 O   ? U HOH .   ? C HOH 314 ? 1_555 87.7  ? 
198 OD1 ? C ASN 101 ? C ASN 97  ? 1_555 CA ? P CA . ? C CA 203 ? 1_555 O   ? U HOH .   ? C HOH 314 ? 1_555 88.0  ? 
199 O   ? C TYR 103 ? C TYR 99  ? 1_555 CA ? P CA . ? C CA 203 ? 1_555 O   ? U HOH .   ? C HOH 314 ? 1_555 97.6  ? 
200 OE1 ? C GLU 108 ? C GLU 104 ? 1_555 CA ? P CA . ? C CA 203 ? 1_555 O   ? U HOH .   ? C HOH 314 ? 1_555 81.7  ? 
201 OE2 ? C GLU 108 ? C GLU 104 ? 1_555 CA ? P CA . ? C CA 203 ? 1_555 O   ? U HOH .   ? C HOH 314 ? 1_555 89.4  ? 
202 OD1 ? C ASP 133 ? C ASP 129 ? 1_555 CA ? Q CA . ? C CA 204 ? 1_555 OD1 ? C ASP 135 ? C ASP 131 ? 1_555 77.9  ? 
203 OD1 ? C ASP 133 ? C ASP 129 ? 1_555 CA ? Q CA . ? C CA 204 ? 1_555 OD1 ? C ASP 137 ? C ASP 133 ? 1_555 89.4  ? 
204 OD1 ? C ASP 135 ? C ASP 131 ? 1_555 CA ? Q CA . ? C CA 204 ? 1_555 OD1 ? C ASP 137 ? C ASP 133 ? 1_555 73.3  ? 
205 OD1 ? C ASP 133 ? C ASP 129 ? 1_555 CA ? Q CA . ? C CA 204 ? 1_555 O   ? C GLN 139 ? C GLN 135 ? 1_555 83.9  ? 
206 OD1 ? C ASP 135 ? C ASP 131 ? 1_555 CA ? Q CA . ? C CA 204 ? 1_555 O   ? C GLN 139 ? C GLN 135 ? 1_555 144.0 ? 
207 OD1 ? C ASP 137 ? C ASP 133 ? 1_555 CA ? Q CA . ? C CA 204 ? 1_555 O   ? C GLN 139 ? C GLN 135 ? 1_555 75.8  ? 
208 OD1 ? C ASP 133 ? C ASP 129 ? 1_555 CA ? Q CA . ? C CA 204 ? 1_555 OE1 ? C GLU 144 ? C GLU 140 ? 1_555 105.7 ? 
209 OD1 ? C ASP 135 ? C ASP 131 ? 1_555 CA ? Q CA . ? C CA 204 ? 1_555 OE1 ? C GLU 144 ? C GLU 140 ? 1_555 131.6 ? 
210 OD1 ? C ASP 137 ? C ASP 133 ? 1_555 CA ? Q CA . ? C CA 204 ? 1_555 OE1 ? C GLU 144 ? C GLU 140 ? 1_555 152.6 ? 
211 O   ? C GLN 139 ? C GLN 135 ? 1_555 CA ? Q CA . ? C CA 204 ? 1_555 OE1 ? C GLU 144 ? C GLU 140 ? 1_555 83.1  ? 
212 OD1 ? C ASP 133 ? C ASP 129 ? 1_555 CA ? Q CA . ? C CA 204 ? 1_555 OE2 ? C GLU 144 ? C GLU 140 ? 1_555 76.4  ? 
213 OD1 ? C ASP 135 ? C ASP 131 ? 1_555 CA ? Q CA . ? C CA 204 ? 1_555 OE2 ? C GLU 144 ? C GLU 140 ? 1_555 84.7  ? 
214 OD1 ? C ASP 137 ? C ASP 133 ? 1_555 CA ? Q CA . ? C CA 204 ? 1_555 OE2 ? C GLU 144 ? C GLU 140 ? 1_555 156.0 ? 
215 O   ? C GLN 139 ? C GLN 135 ? 1_555 CA ? Q CA . ? C CA 204 ? 1_555 OE2 ? C GLU 144 ? C GLU 140 ? 1_555 120.8 ? 
216 OE1 ? C GLU 144 ? C GLU 140 ? 1_555 CA ? Q CA . ? C CA 204 ? 1_555 OE2 ? C GLU 144 ? C GLU 140 ? 1_555 51.4  ? 
217 OD1 ? C ASP 133 ? C ASP 129 ? 1_555 CA ? Q CA . ? C CA 204 ? 1_555 O   ? U HOH .   ? C HOH 308 ? 1_555 166.6 ? 
218 OD1 ? C ASP 135 ? C ASP 131 ? 1_555 CA ? Q CA . ? C CA 204 ? 1_555 O   ? U HOH .   ? C HOH 308 ? 1_555 90.2  ? 
219 OD1 ? C ASP 137 ? C ASP 133 ? 1_555 CA ? Q CA . ? C CA 204 ? 1_555 O   ? U HOH .   ? C HOH 308 ? 1_555 81.2  ? 
220 O   ? C GLN 139 ? C GLN 135 ? 1_555 CA ? Q CA . ? C CA 204 ? 1_555 O   ? U HOH .   ? C HOH 308 ? 1_555 102.9 ? 
221 OE1 ? C GLU 144 ? C GLU 140 ? 1_555 CA ? Q CA . ? C CA 204 ? 1_555 O   ? U HOH .   ? C HOH 308 ? 1_555 86.7  ? 
222 OE2 ? C GLU 144 ? C GLU 140 ? 1_555 CA ? Q CA . ? C CA 204 ? 1_555 O   ? U HOH .   ? C HOH 308 ? 1_555 108.9 ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1  MSE A 40  ? . . . . MSE A 36  ? 1_555 . . . . . . . MET 1 MSE Selenomethionine 'Named protein modification' 
2  MSE A 55  ? . . . . MSE A 51  ? 1_555 . . . . . . . MET 1 MSE Selenomethionine 'Named protein modification' 
3  MSE A 75  ? . . . . MSE A 71  ? 1_555 . . . . . . . MET 1 MSE Selenomethionine 'Named protein modification' 
4  MSE A 76  ? . . . . MSE A 72  ? 1_555 . . . . . . . MET 1 MSE Selenomethionine 'Named protein modification' 
5  MSE A 80  ? . . . . MSE A 76  ? 1_555 . . . . . . . MET 1 MSE Selenomethionine 'Named protein modification' 
6  MSE A 113 ? . . . . MSE A 109 ? 1_555 . . . . . . . MET 1 MSE Selenomethionine 'Named protein modification' 
7  MSE A 128 ? . . . . MSE A 124 ? 1_555 . . . . . . . MET 1 MSE Selenomethionine 'Named protein modification' 
8  MSE A 148 ? . . . . MSE A 144 ? 1_555 . . . . . . . MET 1 MSE Selenomethionine 'Named protein modification' 
9  MSE A 149 ? . . . . MSE A 145 ? 1_555 . . . . . . . MET 1 MSE Selenomethionine 'Named protein modification' 
10 MSE B 40  ? . . . . MSE B 36  ? 1_555 . . . . . . . MET 1 MSE Selenomethionine 'Named protein modification' 
11 MSE B 55  ? . . . . MSE B 51  ? 1_555 . . . . . . . MET 1 MSE Selenomethionine 'Named protein modification' 
12 MSE B 75  ? . . . . MSE B 71  ? 1_555 . . . . . . . MET 1 MSE Selenomethionine 'Named protein modification' 
13 MSE B 76  ? . . . . MSE B 72  ? 1_555 . . . . . . . MET 1 MSE Selenomethionine 'Named protein modification' 
14 MSE B 113 ? . . . . MSE B 109 ? 1_555 . . . . . . . MET 1 MSE Selenomethionine 'Named protein modification' 
15 MSE B 128 ? . . . . MSE B 124 ? 1_555 . . . . . . . MET 1 MSE Selenomethionine 'Named protein modification' 
16 MSE B 148 ? . . . . MSE B 144 ? 1_555 . . . . . . . MET 1 MSE Selenomethionine 'Named protein modification' 
17 MSE B 149 ? . . . . MSE B 145 ? 1_555 . . . . . . . MET 1 MSE Selenomethionine 'Named protein modification' 
18 MSE C 40  ? . . . . MSE C 36  ? 1_555 . . . . . . . MET 1 MSE Selenomethionine 'Named protein modification' 
19 MSE C 55  ? . . . . MSE C 51  ? 1_555 . . . . . . . MET 1 MSE Selenomethionine 'Named protein modification' 
20 MSE C 75  ? . . . . MSE C 71  ? 1_555 . . . . . . . MET 1 MSE Selenomethionine 'Named protein modification' 
21 MSE C 76  ? . . . . MSE C 72  ? 1_555 . . . . . . . MET 1 MSE Selenomethionine 'Named protein modification' 
22 MSE C 113 ? . . . . MSE C 109 ? 1_555 . . . . . . . MET 1 MSE Selenomethionine 'Named protein modification' 
23 MSE C 128 ? . . . . MSE C 124 ? 1_555 . . . . . . . MET 1 MSE Selenomethionine 'Named protein modification' 
24 MSE C 148 ? . . . . MSE C 144 ? 1_555 . . . . . . . MET 1 MSE Selenomethionine 'Named protein modification' 
25 MSE C 149 ? . . . . MSE C 145 ? 1_555 . . . . . . . MET 1 MSE Selenomethionine 'Named protein modification' 
# 
_pdbx_entry_details.entry_id                   9JQI 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASN B 42  ? ? -153.25 77.96   
2 1 ALA C 73  ? ? -98.06  -63.22  
3 1 THR C 146 ? ? -103.77 -169.11 
# 
loop_
_pdbx_struct_mod_residue.id 
_pdbx_struct_mod_residue.label_asym_id 
_pdbx_struct_mod_residue.label_comp_id 
_pdbx_struct_mod_residue.label_seq_id 
_pdbx_struct_mod_residue.auth_asym_id 
_pdbx_struct_mod_residue.auth_comp_id 
_pdbx_struct_mod_residue.auth_seq_id 
_pdbx_struct_mod_residue.PDB_ins_code 
_pdbx_struct_mod_residue.parent_comp_id 
_pdbx_struct_mod_residue.details 
1  A MSE 40  A MSE 36  ? MET 'modified residue' 
2  A MSE 55  A MSE 51  ? MET 'modified residue' 
3  A MSE 75  A MSE 71  ? MET 'modified residue' 
4  A MSE 76  A MSE 72  ? MET 'modified residue' 
5  A MSE 80  A MSE 76  ? MET 'modified residue' 
6  A MSE 113 A MSE 109 ? MET 'modified residue' 
7  A MSE 128 A MSE 124 ? MET 'modified residue' 
8  A MSE 148 A MSE 144 ? MET 'modified residue' 
9  A MSE 149 A MSE 145 ? MET 'modified residue' 
10 B MSE 40  B MSE 36  ? MET 'modified residue' 
11 B MSE 55  B MSE 51  ? MET 'modified residue' 
12 B MSE 75  B MSE 71  ? MET 'modified residue' 
13 B MSE 76  B MSE 72  ? MET 'modified residue' 
14 B MSE 113 B MSE 109 ? MET 'modified residue' 
15 B MSE 128 B MSE 124 ? MET 'modified residue' 
16 B MSE 148 B MSE 144 ? MET 'modified residue' 
17 B MSE 149 B MSE 145 ? MET 'modified residue' 
18 C MSE 40  C MSE 36  ? MET 'modified residue' 
19 C MSE 55  C MSE 51  ? MET 'modified residue' 
20 C MSE 75  C MSE 71  ? MET 'modified residue' 
21 C MSE 76  C MSE 72  ? MET 'modified residue' 
22 C MSE 113 C MSE 109 ? MET 'modified residue' 
23 C MSE 128 C MSE 124 ? MET 'modified residue' 
24 C MSE 148 C MSE 144 ? MET 'modified residue' 
25 C MSE 149 C MSE 145 ? MET 'modified residue' 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 -x,y,-z         
3 x+1/2,y+1/2,z   
4 -x+1/2,y+1/2,-z 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY -3  ? A GLY 1   
2  1 Y 1 A PRO -2  ? A PRO 2   
3  1 Y 1 A HIS -1  ? A HIS 3   
4  1 Y 1 A MSE 0   ? A MSE 4   
5  1 Y 1 A ALA 1   ? A ALA 5   
6  1 Y 1 A ASP 2   ? A ASP 6   
7  1 Y 1 A GLN 3   ? A GLN 7   
8  1 Y 1 A LYS 77  ? A LYS 81  
9  1 Y 1 A ASP 78  ? A ASP 82  
10 1 Y 1 A GLY 150 ? A GLY 154 
11 1 Y 1 A LEU 151 ? A LEU 155 
12 1 Y 1 B GLY -3  ? B GLY 1   
13 1 Y 1 B PRO -2  ? B PRO 2   
14 1 Y 1 B HIS -1  ? B HIS 3   
15 1 Y 1 B MSE 0   ? B MSE 4   
16 1 Y 1 B ALA 1   ? B ALA 5   
17 1 Y 1 B ASP 2   ? B ASP 6   
18 1 Y 1 B GLN 3   ? B GLN 7   
19 1 Y 1 B LEU 4   ? B LEU 8   
20 1 Y 1 B MSE 76  ? B MSE 80  
21 1 Y 1 B LYS 77  ? B LYS 81  
22 1 Y 1 B ASP 78  ? B ASP 82  
23 1 Y 1 B THR 79  ? B THR 83  
24 1 Y 1 B ASP 80  ? B ASP 84  
25 1 Y 1 B GLY 150 ? B GLY 154 
26 1 Y 1 B LEU 151 ? B LEU 155 
27 1 Y 1 C GLY -3  ? C GLY 1   
28 1 Y 1 C PRO -2  ? C PRO 2   
29 1 Y 1 C HIS -1  ? C HIS 3   
30 1 Y 1 C MSE 0   ? C MSE 4   
31 1 Y 1 C ALA 1   ? C ALA 5   
32 1 Y 1 C ASP 2   ? C ASP 6   
33 1 Y 1 C GLN 3   ? C GLN 7   
34 1 Y 1 C LEU 4   ? C LEU 8   
35 1 Y 1 C LYS 75  ? C LYS 79  
36 1 Y 1 C MSE 76  ? C MSE 80  
37 1 Y 1 C LYS 77  ? C LYS 81  
38 1 Y 1 C ASP 78  ? C ASP 82  
39 1 Y 1 C THR 79  ? C THR 83  
40 1 Y 1 C ASP 80  ? C ASP 84  
41 1 Y 1 C ASN 149 ? C ASN 153 
42 1 Y 1 C GLY 150 ? C GLY 154 
43 1 Y 1 C LEU 151 ? C LEU 155 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CA  CA   CA N N 74  
GLN N    N  N N 75  
GLN CA   C  N S 76  
GLN C    C  N N 77  
GLN O    O  N N 78  
GLN CB   C  N N 79  
GLN CG   C  N N 80  
GLN CD   C  N N 81  
GLN OE1  O  N N 82  
GLN NE2  N  N N 83  
GLN OXT  O  N N 84  
GLN H    H  N N 85  
GLN H2   H  N N 86  
GLN HA   H  N N 87  
GLN HB2  H  N N 88  
GLN HB3  H  N N 89  
GLN HG2  H  N N 90  
GLN HG3  H  N N 91  
GLN HE21 H  N N 92  
GLN HE22 H  N N 93  
GLN HXT  H  N N 94  
GLU N    N  N N 95  
GLU CA   C  N S 96  
GLU C    C  N N 97  
GLU O    O  N N 98  
GLU CB   C  N N 99  
GLU CG   C  N N 100 
GLU CD   C  N N 101 
GLU OE1  O  N N 102 
GLU OE2  O  N N 103 
GLU OXT  O  N N 104 
GLU H    H  N N 105 
GLU H2   H  N N 106 
GLU HA   H  N N 107 
GLU HB2  H  N N 108 
GLU HB3  H  N N 109 
GLU HG2  H  N N 110 
GLU HG3  H  N N 111 
GLU HE2  H  N N 112 
GLU HXT  H  N N 113 
GLY N    N  N N 114 
GLY CA   C  N N 115 
GLY C    C  N N 116 
GLY O    O  N N 117 
GLY OXT  O  N N 118 
GLY H    H  N N 119 
GLY H2   H  N N 120 
GLY HA2  H  N N 121 
GLY HA3  H  N N 122 
GLY HXT  H  N N 123 
HIS N    N  N N 124 
HIS CA   C  N S 125 
HIS C    C  N N 126 
HIS O    O  N N 127 
HIS CB   C  N N 128 
HIS CG   C  Y N 129 
HIS ND1  N  Y N 130 
HIS CD2  C  Y N 131 
HIS CE1  C  Y N 132 
HIS NE2  N  Y N 133 
HIS OXT  O  N N 134 
HIS H    H  N N 135 
HIS H2   H  N N 136 
HIS HA   H  N N 137 
HIS HB2  H  N N 138 
HIS HB3  H  N N 139 
HIS HD1  H  N N 140 
HIS HD2  H  N N 141 
HIS HE1  H  N N 142 
HIS HE2  H  N N 143 
HIS HXT  H  N N 144 
HOH O    O  N N 145 
HOH H1   H  N N 146 
HOH H2   H  N N 147 
ILE N    N  N N 148 
ILE CA   C  N S 149 
ILE C    C  N N 150 
ILE O    O  N N 151 
ILE CB   C  N S 152 
ILE CG1  C  N N 153 
ILE CG2  C  N N 154 
ILE CD1  C  N N 155 
ILE OXT  O  N N 156 
ILE H    H  N N 157 
ILE H2   H  N N 158 
ILE HA   H  N N 159 
ILE HB   H  N N 160 
ILE HG12 H  N N 161 
ILE HG13 H  N N 162 
ILE HG21 H  N N 163 
ILE HG22 H  N N 164 
ILE HG23 H  N N 165 
ILE HD11 H  N N 166 
ILE HD12 H  N N 167 
ILE HD13 H  N N 168 
ILE HXT  H  N N 169 
KN9 C1   C  N N 170 
KN9 C10  C  Y N 171 
KN9 C11  C  N N 172 
KN9 C12  C  Y N 173 
KN9 C13  C  Y N 174 
KN9 C14  C  Y N 175 
KN9 C15  C  Y N 176 
KN9 C16  C  Y N 177 
KN9 C17  C  Y N 178 
KN9 C18  C  N N 179 
KN9 C19  C  Y N 180 
KN9 C2   C  N N 181 
KN9 C20  C  Y N 182 
KN9 C21  C  Y N 183 
KN9 C22  C  Y N 184 
KN9 C23  C  Y N 185 
KN9 C24  C  Y N 186 
KN9 C26  C  N N 187 
KN9 C27  C  N N 188 
KN9 C3   C  N N 189 
KN9 C4   C  N N 190 
KN9 C5   C  Y N 191 
KN9 C6   C  Y N 192 
KN9 C7   C  Y N 193 
KN9 C8   C  Y N 194 
KN9 C9   C  Y N 195 
KN9 N1   N  N N 196 
KN9 N2   N  N N 197 
KN9 O1   O  N N 198 
KN9 O2   O  N N 199 
KN9 O25  O  N N 200 
KN9 O3   O  N N 201 
KN9 S    S  N N 202 
KN9 CL   CL N N 203 
KN9 H1   H  N N 204 
KN9 H2   H  N N 205 
KN9 H3   H  N N 206 
KN9 H4   H  N N 207 
KN9 H5   H  N N 208 
KN9 H6   H  N N 209 
KN9 H7   H  N N 210 
KN9 H8   H  N N 211 
KN9 H9   H  N N 212 
KN9 H10  H  N N 213 
KN9 H11  H  N N 214 
KN9 H12  H  N N 215 
KN9 H13  H  N N 216 
KN9 H14  H  N N 217 
KN9 H15  H  N N 218 
KN9 H16  H  N N 219 
KN9 H17  H  N N 220 
KN9 H18  H  N N 221 
KN9 H19  H  N N 222 
KN9 H20  H  N N 223 
KN9 H21  H  N N 224 
KN9 H22  H  N N 225 
KN9 H23  H  N N 226 
KN9 H25  H  N N 227 
KN9 H27  H  N N 228 
KN9 H28  H  N N 229 
KN9 H29  H  N N 230 
KN9 H24  H  N N 231 
KN9 H26  H  N N 232 
LEU N    N  N N 233 
LEU CA   C  N S 234 
LEU C    C  N N 235 
LEU O    O  N N 236 
LEU CB   C  N N 237 
LEU CG   C  N N 238 
LEU CD1  C  N N 239 
LEU CD2  C  N N 240 
LEU OXT  O  N N 241 
LEU H    H  N N 242 
LEU H2   H  N N 243 
LEU HA   H  N N 244 
LEU HB2  H  N N 245 
LEU HB3  H  N N 246 
LEU HG   H  N N 247 
LEU HD11 H  N N 248 
LEU HD12 H  N N 249 
LEU HD13 H  N N 250 
LEU HD21 H  N N 251 
LEU HD22 H  N N 252 
LEU HD23 H  N N 253 
LEU HXT  H  N N 254 
LYS N    N  N N 255 
LYS CA   C  N S 256 
LYS C    C  N N 257 
LYS O    O  N N 258 
LYS CB   C  N N 259 
LYS CG   C  N N 260 
LYS CD   C  N N 261 
LYS CE   C  N N 262 
LYS NZ   N  N N 263 
LYS OXT  O  N N 264 
LYS H    H  N N 265 
LYS H2   H  N N 266 
LYS HA   H  N N 267 
LYS HB2  H  N N 268 
LYS HB3  H  N N 269 
LYS HG2  H  N N 270 
LYS HG3  H  N N 271 
LYS HD2  H  N N 272 
LYS HD3  H  N N 273 
LYS HE2  H  N N 274 
LYS HE3  H  N N 275 
LYS HZ1  H  N N 276 
LYS HZ2  H  N N 277 
LYS HZ3  H  N N 278 
LYS HXT  H  N N 279 
MSE N    N  N N 280 
MSE CA   C  N S 281 
MSE C    C  N N 282 
MSE O    O  N N 283 
MSE OXT  O  N N 284 
MSE CB   C  N N 285 
MSE CG   C  N N 286 
MSE SE   SE N N 287 
MSE CE   C  N N 288 
MSE H    H  N N 289 
MSE H2   H  N N 290 
MSE HA   H  N N 291 
MSE HXT  H  N N 292 
MSE HB2  H  N N 293 
MSE HB3  H  N N 294 
MSE HG2  H  N N 295 
MSE HG3  H  N N 296 
MSE HE1  H  N N 297 
MSE HE2  H  N N 298 
MSE HE3  H  N N 299 
PHE N    N  N N 300 
PHE CA   C  N S 301 
PHE C    C  N N 302 
PHE O    O  N N 303 
PHE CB   C  N N 304 
PHE CG   C  Y N 305 
PHE CD1  C  Y N 306 
PHE CD2  C  Y N 307 
PHE CE1  C  Y N 308 
PHE CE2  C  Y N 309 
PHE CZ   C  Y N 310 
PHE OXT  O  N N 311 
PHE H    H  N N 312 
PHE H2   H  N N 313 
PHE HA   H  N N 314 
PHE HB2  H  N N 315 
PHE HB3  H  N N 316 
PHE HD1  H  N N 317 
PHE HD2  H  N N 318 
PHE HE1  H  N N 319 
PHE HE2  H  N N 320 
PHE HZ   H  N N 321 
PHE HXT  H  N N 322 
PRO N    N  N N 323 
PRO CA   C  N S 324 
PRO C    C  N N 325 
PRO O    O  N N 326 
PRO CB   C  N N 327 
PRO CG   C  N N 328 
PRO CD   C  N N 329 
PRO OXT  O  N N 330 
PRO H    H  N N 331 
PRO HA   H  N N 332 
PRO HB2  H  N N 333 
PRO HB3  H  N N 334 
PRO HG2  H  N N 335 
PRO HG3  H  N N 336 
PRO HD2  H  N N 337 
PRO HD3  H  N N 338 
PRO HXT  H  N N 339 
SER N    N  N N 340 
SER CA   C  N S 341 
SER C    C  N N 342 
SER O    O  N N 343 
SER CB   C  N N 344 
SER OG   O  N N 345 
SER OXT  O  N N 346 
SER H    H  N N 347 
SER H2   H  N N 348 
SER HA   H  N N 349 
SER HB2  H  N N 350 
SER HB3  H  N N 351 
SER HG   H  N N 352 
SER HXT  H  N N 353 
THR N    N  N N 354 
THR CA   C  N S 355 
THR C    C  N N 356 
THR O    O  N N 357 
THR CB   C  N R 358 
THR OG1  O  N N 359 
THR CG2  C  N N 360 
THR OXT  O  N N 361 
THR H    H  N N 362 
THR H2   H  N N 363 
THR HA   H  N N 364 
THR HB   H  N N 365 
THR HG1  H  N N 366 
THR HG21 H  N N 367 
THR HG22 H  N N 368 
THR HG23 H  N N 369 
THR HXT  H  N N 370 
TYR N    N  N N 371 
TYR CA   C  N S 372 
TYR C    C  N N 373 
TYR O    O  N N 374 
TYR CB   C  N N 375 
TYR CG   C  Y N 376 
TYR CD1  C  Y N 377 
TYR CD2  C  Y N 378 
TYR CE1  C  Y N 379 
TYR CE2  C  Y N 380 
TYR CZ   C  Y N 381 
TYR OH   O  N N 382 
TYR OXT  O  N N 383 
TYR H    H  N N 384 
TYR H2   H  N N 385 
TYR HA   H  N N 386 
TYR HB2  H  N N 387 
TYR HB3  H  N N 388 
TYR HD1  H  N N 389 
TYR HD2  H  N N 390 
TYR HE1  H  N N 391 
TYR HE2  H  N N 392 
TYR HH   H  N N 393 
TYR HXT  H  N N 394 
VAL N    N  N N 395 
VAL CA   C  N S 396 
VAL C    C  N N 397 
VAL O    O  N N 398 
VAL CB   C  N N 399 
VAL CG1  C  N N 400 
VAL CG2  C  N N 401 
VAL OXT  O  N N 402 
VAL H    H  N N 403 
VAL H2   H  N N 404 
VAL HA   H  N N 405 
VAL HB   H  N N 406 
VAL HG11 H  N N 407 
VAL HG12 H  N N 408 
VAL HG13 H  N N 409 
VAL HG21 H  N N 410 
VAL HG22 H  N N 411 
VAL HG23 H  N N 412 
VAL HXT  H  N N 413 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
GLN N   CA   sing N N 70  
GLN N   H    sing N N 71  
GLN N   H2   sing N N 72  
GLN CA  C    sing N N 73  
GLN CA  CB   sing N N 74  
GLN CA  HA   sing N N 75  
GLN C   O    doub N N 76  
GLN C   OXT  sing N N 77  
GLN CB  CG   sing N N 78  
GLN CB  HB2  sing N N 79  
GLN CB  HB3  sing N N 80  
GLN CG  CD   sing N N 81  
GLN CG  HG2  sing N N 82  
GLN CG  HG3  sing N N 83  
GLN CD  OE1  doub N N 84  
GLN CD  NE2  sing N N 85  
GLN NE2 HE21 sing N N 86  
GLN NE2 HE22 sing N N 87  
GLN OXT HXT  sing N N 88  
GLU N   CA   sing N N 89  
GLU N   H    sing N N 90  
GLU N   H2   sing N N 91  
GLU CA  C    sing N N 92  
GLU CA  CB   sing N N 93  
GLU CA  HA   sing N N 94  
GLU C   O    doub N N 95  
GLU C   OXT  sing N N 96  
GLU CB  CG   sing N N 97  
GLU CB  HB2  sing N N 98  
GLU CB  HB3  sing N N 99  
GLU CG  CD   sing N N 100 
GLU CG  HG2  sing N N 101 
GLU CG  HG3  sing N N 102 
GLU CD  OE1  doub N N 103 
GLU CD  OE2  sing N N 104 
GLU OE2 HE2  sing N N 105 
GLU OXT HXT  sing N N 106 
GLY N   CA   sing N N 107 
GLY N   H    sing N N 108 
GLY N   H2   sing N N 109 
GLY CA  C    sing N N 110 
GLY CA  HA2  sing N N 111 
GLY CA  HA3  sing N N 112 
GLY C   O    doub N N 113 
GLY C   OXT  sing N N 114 
GLY OXT HXT  sing N N 115 
HIS N   CA   sing N N 116 
HIS N   H    sing N N 117 
HIS N   H2   sing N N 118 
HIS CA  C    sing N N 119 
HIS CA  CB   sing N N 120 
HIS CA  HA   sing N N 121 
HIS C   O    doub N N 122 
HIS C   OXT  sing N N 123 
HIS CB  CG   sing N N 124 
HIS CB  HB2  sing N N 125 
HIS CB  HB3  sing N N 126 
HIS CG  ND1  sing Y N 127 
HIS CG  CD2  doub Y N 128 
HIS ND1 CE1  doub Y N 129 
HIS ND1 HD1  sing N N 130 
HIS CD2 NE2  sing Y N 131 
HIS CD2 HD2  sing N N 132 
HIS CE1 NE2  sing Y N 133 
HIS CE1 HE1  sing N N 134 
HIS NE2 HE2  sing N N 135 
HIS OXT HXT  sing N N 136 
HOH O   H1   sing N N 137 
HOH O   H2   sing N N 138 
ILE N   CA   sing N N 139 
ILE N   H    sing N N 140 
ILE N   H2   sing N N 141 
ILE CA  C    sing N N 142 
ILE CA  CB   sing N N 143 
ILE CA  HA   sing N N 144 
ILE C   O    doub N N 145 
ILE C   OXT  sing N N 146 
ILE CB  CG1  sing N N 147 
ILE CB  CG2  sing N N 148 
ILE CB  HB   sing N N 149 
ILE CG1 CD1  sing N N 150 
ILE CG1 HG12 sing N N 151 
ILE CG1 HG13 sing N N 152 
ILE CG2 HG21 sing N N 153 
ILE CG2 HG22 sing N N 154 
ILE CG2 HG23 sing N N 155 
ILE CD1 HD11 sing N N 156 
ILE CD1 HD12 sing N N 157 
ILE CD1 HD13 sing N N 158 
ILE OXT HXT  sing N N 159 
KN9 O1  C27  sing N N 160 
KN9 C27 C18  sing N N 161 
KN9 C18 N2   sing N N 162 
KN9 C1  N1   sing N N 163 
KN9 N1  C2   sing N N 164 
KN9 N1  C11  sing N N 165 
KN9 C2  C3   sing N N 166 
KN9 N2  C17  sing N N 167 
KN9 N2  S    sing N N 168 
KN9 C3  C4   doub N E 169 
KN9 C16 C17  doub Y N 170 
KN9 C16 C15  sing Y N 171 
KN9 C17 C12  sing Y N 172 
KN9 C15 C14  doub Y N 173 
KN9 O2  S    doub N N 174 
KN9 C12 C11  sing N N 175 
KN9 C12 C13  doub Y N 176 
KN9 C6  C7   doub Y N 177 
KN9 C6  C5   sing Y N 178 
KN9 C14 C13  sing Y N 179 
KN9 C24 C23  doub Y N 180 
KN9 C24 C19  sing Y N 181 
KN9 C4  C5   sing N N 182 
KN9 S   C19  sing N N 183 
KN9 S   O3   doub N N 184 
KN9 C7  C8   sing Y N 185 
KN9 C23 C22  sing Y N 186 
KN9 C5  C10  doub Y N 187 
KN9 C19 C20  doub Y N 188 
KN9 C26 O25  sing N N 189 
KN9 C8  CL   sing N N 190 
KN9 C8  C9   doub Y N 191 
KN9 C22 O25  sing N N 192 
KN9 C22 C21  doub Y N 193 
KN9 C10 C9   sing Y N 194 
KN9 C20 C21  sing Y N 195 
KN9 C1  H1   sing N N 196 
KN9 C1  H2   sing N N 197 
KN9 C1  H3   sing N N 198 
KN9 C10 H4   sing N N 199 
KN9 C11 H5   sing N N 200 
KN9 C11 H6   sing N N 201 
KN9 C13 H7   sing N N 202 
KN9 C14 H8   sing N N 203 
KN9 C15 H9   sing N N 204 
KN9 C16 H10  sing N N 205 
KN9 C18 H11  sing N N 206 
KN9 C18 H12  sing N N 207 
KN9 C2  H13  sing N N 208 
KN9 C2  H14  sing N N 209 
KN9 C20 H15  sing N N 210 
KN9 C21 H16  sing N N 211 
KN9 C23 H17  sing N N 212 
KN9 C24 H18  sing N N 213 
KN9 C26 H19  sing N N 214 
KN9 C26 H20  sing N N 215 
KN9 C26 H21  sing N N 216 
KN9 C27 H22  sing N N 217 
KN9 C3  H23  sing N N 218 
KN9 C4  H25  sing N N 219 
KN9 C6  H27  sing N N 220 
KN9 C7  H28  sing N N 221 
KN9 C9  H29  sing N N 222 
KN9 C27 H24  sing N N 223 
KN9 O1  H26  sing N N 224 
LEU N   CA   sing N N 225 
LEU N   H    sing N N 226 
LEU N   H2   sing N N 227 
LEU CA  C    sing N N 228 
LEU CA  CB   sing N N 229 
LEU CA  HA   sing N N 230 
LEU C   O    doub N N 231 
LEU C   OXT  sing N N 232 
LEU CB  CG   sing N N 233 
LEU CB  HB2  sing N N 234 
LEU CB  HB3  sing N N 235 
LEU CG  CD1  sing N N 236 
LEU CG  CD2  sing N N 237 
LEU CG  HG   sing N N 238 
LEU CD1 HD11 sing N N 239 
LEU CD1 HD12 sing N N 240 
LEU CD1 HD13 sing N N 241 
LEU CD2 HD21 sing N N 242 
LEU CD2 HD22 sing N N 243 
LEU CD2 HD23 sing N N 244 
LEU OXT HXT  sing N N 245 
LYS N   CA   sing N N 246 
LYS N   H    sing N N 247 
LYS N   H2   sing N N 248 
LYS CA  C    sing N N 249 
LYS CA  CB   sing N N 250 
LYS CA  HA   sing N N 251 
LYS C   O    doub N N 252 
LYS C   OXT  sing N N 253 
LYS CB  CG   sing N N 254 
LYS CB  HB2  sing N N 255 
LYS CB  HB3  sing N N 256 
LYS CG  CD   sing N N 257 
LYS CG  HG2  sing N N 258 
LYS CG  HG3  sing N N 259 
LYS CD  CE   sing N N 260 
LYS CD  HD2  sing N N 261 
LYS CD  HD3  sing N N 262 
LYS CE  NZ   sing N N 263 
LYS CE  HE2  sing N N 264 
LYS CE  HE3  sing N N 265 
LYS NZ  HZ1  sing N N 266 
LYS NZ  HZ2  sing N N 267 
LYS NZ  HZ3  sing N N 268 
LYS OXT HXT  sing N N 269 
MSE N   CA   sing N N 270 
MSE N   H    sing N N 271 
MSE N   H2   sing N N 272 
MSE CA  C    sing N N 273 
MSE CA  CB   sing N N 274 
MSE CA  HA   sing N N 275 
MSE C   O    doub N N 276 
MSE C   OXT  sing N N 277 
MSE OXT HXT  sing N N 278 
MSE CB  CG   sing N N 279 
MSE CB  HB2  sing N N 280 
MSE CB  HB3  sing N N 281 
MSE CG  SE   sing N N 282 
MSE CG  HG2  sing N N 283 
MSE CG  HG3  sing N N 284 
MSE SE  CE   sing N N 285 
MSE CE  HE1  sing N N 286 
MSE CE  HE2  sing N N 287 
MSE CE  HE3  sing N N 288 
PHE N   CA   sing N N 289 
PHE N   H    sing N N 290 
PHE N   H2   sing N N 291 
PHE CA  C    sing N N 292 
PHE CA  CB   sing N N 293 
PHE CA  HA   sing N N 294 
PHE C   O    doub N N 295 
PHE C   OXT  sing N N 296 
PHE CB  CG   sing N N 297 
PHE CB  HB2  sing N N 298 
PHE CB  HB3  sing N N 299 
PHE CG  CD1  doub Y N 300 
PHE CG  CD2  sing Y N 301 
PHE CD1 CE1  sing Y N 302 
PHE CD1 HD1  sing N N 303 
PHE CD2 CE2  doub Y N 304 
PHE CD2 HD2  sing N N 305 
PHE CE1 CZ   doub Y N 306 
PHE CE1 HE1  sing N N 307 
PHE CE2 CZ   sing Y N 308 
PHE CE2 HE2  sing N N 309 
PHE CZ  HZ   sing N N 310 
PHE OXT HXT  sing N N 311 
PRO N   CA   sing N N 312 
PRO N   CD   sing N N 313 
PRO N   H    sing N N 314 
PRO CA  C    sing N N 315 
PRO CA  CB   sing N N 316 
PRO CA  HA   sing N N 317 
PRO C   O    doub N N 318 
PRO C   OXT  sing N N 319 
PRO CB  CG   sing N N 320 
PRO CB  HB2  sing N N 321 
PRO CB  HB3  sing N N 322 
PRO CG  CD   sing N N 323 
PRO CG  HG2  sing N N 324 
PRO CG  HG3  sing N N 325 
PRO CD  HD2  sing N N 326 
PRO CD  HD3  sing N N 327 
PRO OXT HXT  sing N N 328 
SER N   CA   sing N N 329 
SER N   H    sing N N 330 
SER N   H2   sing N N 331 
SER CA  C    sing N N 332 
SER CA  CB   sing N N 333 
SER CA  HA   sing N N 334 
SER C   O    doub N N 335 
SER C   OXT  sing N N 336 
SER CB  OG   sing N N 337 
SER CB  HB2  sing N N 338 
SER CB  HB3  sing N N 339 
SER OG  HG   sing N N 340 
SER OXT HXT  sing N N 341 
THR N   CA   sing N N 342 
THR N   H    sing N N 343 
THR N   H2   sing N N 344 
THR CA  C    sing N N 345 
THR CA  CB   sing N N 346 
THR CA  HA   sing N N 347 
THR C   O    doub N N 348 
THR C   OXT  sing N N 349 
THR CB  OG1  sing N N 350 
THR CB  CG2  sing N N 351 
THR CB  HB   sing N N 352 
THR OG1 HG1  sing N N 353 
THR CG2 HG21 sing N N 354 
THR CG2 HG22 sing N N 355 
THR CG2 HG23 sing N N 356 
THR OXT HXT  sing N N 357 
TYR N   CA   sing N N 358 
TYR N   H    sing N N 359 
TYR N   H2   sing N N 360 
TYR CA  C    sing N N 361 
TYR CA  CB   sing N N 362 
TYR CA  HA   sing N N 363 
TYR C   O    doub N N 364 
TYR C   OXT  sing N N 365 
TYR CB  CG   sing N N 366 
TYR CB  HB2  sing N N 367 
TYR CB  HB3  sing N N 368 
TYR CG  CD1  doub Y N 369 
TYR CG  CD2  sing Y N 370 
TYR CD1 CE1  sing Y N 371 
TYR CD1 HD1  sing N N 372 
TYR CD2 CE2  doub Y N 373 
TYR CD2 HD2  sing N N 374 
TYR CE1 CZ   doub Y N 375 
TYR CE1 HE1  sing N N 376 
TYR CE2 CZ   sing Y N 377 
TYR CE2 HE2  sing N N 378 
TYR CZ  OH   sing N N 379 
TYR OH  HH   sing N N 380 
TYR OXT HXT  sing N N 381 
VAL N   CA   sing N N 382 
VAL N   H    sing N N 383 
VAL N   H2   sing N N 384 
VAL CA  C    sing N N 385 
VAL CA  CB   sing N N 386 
VAL CA  HA   sing N N 387 
VAL C   O    doub N N 388 
VAL C   OXT  sing N N 389 
VAL CB  CG1  sing N N 390 
VAL CB  CG2  sing N N 391 
VAL CB  HB   sing N N 392 
VAL CG1 HG11 sing N N 393 
VAL CG1 HG12 sing N N 394 
VAL CG1 HG13 sing N N 395 
VAL CG2 HG21 sing N N 396 
VAL CG2 HG22 sing N N 397 
VAL CG2 HG23 sing N N 398 
VAL OXT HXT  sing N N 399 
# 
_pdbx_audit_support.funding_organization   'National Science Foundation (NSF, China)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   6m7h 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'C 1 2 1' 
_space_group.name_Hall        'C 2y' 
_space_group.IT_number        5 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9JQI 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.014423 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000622 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.024836 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.005772 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356  2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
CA ? ? 16.26893 3.65395 ? ? 3.58509  77.28589 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
CL ? ? 9.50761  7.44341 ? ? 1.04373  23.83732 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032  2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882  3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732  6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
SE ? ? 26.02326 7.89457 ? ? 1.54240  29.12501 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . LEU A 1 8   ? -13.06787 -12.76166 31.20629 1.000 62.33967  ? 4   LEU A N   1 
ATOM   2    C  CA  . LEU A 1 8   ? -12.41508 -12.16858 30.04450 1.000 67.65502  ? 4   LEU A CA  1 
ATOM   3    C  C   . LEU A 1 8   ? -11.23460 -11.29851 30.46267 1.000 65.58124  ? 4   LEU A C   1 
ATOM   4    O  O   . LEU A 1 8   ? -11.31526 -10.55577 31.44129 1.000 66.86803  ? 4   LEU A O   1 
ATOM   5    C  CB  . LEU A 1 8   ? -13.41111 -11.33990 29.22844 1.000 61.96305  ? 4   LEU A CB  1 
ATOM   6    C  CG  . LEU A 1 8   ? -14.79937 -11.93179 28.97454 1.000 66.32197  ? 4   LEU A CG  1 
ATOM   7    C  CD1 . LEU A 1 8   ? -15.59096 -11.03924 28.03190 1.000 67.28034  ? 4   LEU A CD1 1 
ATOM   8    C  CD2 . LEU A 1 8   ? -14.69717 -13.34089 28.41052 1.000 64.28184  ? 4   LEU A CD2 1 
ATOM   9    N  N   . THR A 1 9   ? -10.13767 -11.39530 29.71572 1.000 69.01129  ? 5   THR A N   1 
ATOM   10   C  CA  . THR A 1 9   ? -8.97121  -10.57492 29.99650 1.000 65.66555  ? 5   THR A CA  1 
ATOM   11   C  C   . THR A 1 9   ? -9.22702  -9.12718  29.57890 1.000 64.67785  ? 5   THR A C   1 
ATOM   12   O  O   . THR A 1 9   ? -10.20998 -8.80586  28.90504 1.000 63.99947  ? 5   THR A O   1 
ATOM   13   C  CB  . THR A 1 9   ? -7.73706  -11.12849 29.28326 1.000 64.92960  ? 5   THR A CB  1 
ATOM   14   O  OG1 . THR A 1 9   ? -7.73876  -10.70254 27.91412 1.000 68.42040  ? 5   THR A OG1 1 
ATOM   15   C  CG2 . THR A 1 9   ? -7.72320  -12.64889 29.34262 1.000 69.37799  ? 5   THR A CG2 1 
ATOM   16   N  N   . GLU A 1 10  ? -8.31432  -8.24391  29.98985 1.000 59.69894  ? 6   GLU A N   1 
ATOM   17   C  CA  . GLU A 1 10  ? -8.49897  -6.81877  29.73516 1.000 58.98206  ? 6   GLU A CA  1 
ATOM   18   C  C   . GLU A 1 10  ? -8.25849  -6.48141  28.26621 1.000 59.96466  ? 6   GLU A C   1 
ATOM   19   O  O   . GLU A 1 10  ? -8.93821  -5.61331  27.70416 1.000 54.13786  ? 6   GLU A O   1 
ATOM   20   C  CB  . GLU A 1 10  ? -7.57757  -6.00887  30.64850 1.000 59.39499  ? 6   GLU A CB  1 
ATOM   21   C  CG  . GLU A 1 10  ? -7.51222  -4.52614  30.33518 1.000 65.48313  ? 6   GLU A CG  1 
ATOM   22   C  CD  . GLU A 1 10  ? -6.66667  -3.76537  31.33632 1.000 73.06464  ? 6   GLU A CD  1 
ATOM   23   O  OE1 . GLU A 1 10  ? -6.26104  -4.37103  32.35112 1.000 59.02713  ? 6   GLU A OE1 1 
ATOM   24   O  OE2 . GLU A 1 10  ? -6.41133  -2.56301  31.11332 1.000 74.72209  ? 6   GLU A OE2 1 
ATOM   25   N  N   . GLU A 1 11  ? -7.29660  -7.15502  27.62830 1.000 64.60902  ? 7   GLU A N   1 
ATOM   26   C  CA  . GLU A 1 11  ? -7.11112  -7.00350  26.18682 1.000 63.26119  ? 7   GLU A CA  1 
ATOM   27   C  C   . GLU A 1 11  ? -8.37709  -7.38410  25.42900 1.000 56.72739  ? 7   GLU A C   1 
ATOM   28   O  O   . GLU A 1 11  ? -8.84321  -6.64087  24.55669 1.000 55.03548  ? 7   GLU A O   1 
ATOM   29   C  CB  . GLU A 1 11  ? -5.93674  -7.86010  25.71857 1.000 59.66512  ? 7   GLU A CB  1 
ATOM   30   C  CG  . GLU A 1 11  ? -5.28419  -7.37548  24.43979 1.000 65.39776  ? 7   GLU A CG  1 
ATOM   31   C  CD  . GLU A 1 11  ? -4.92782  -8.52096  23.51373 1.000 70.68145  ? 7   GLU A CD  1 
ATOM   32   O  OE1 . GLU A 1 11  ? -5.06228  -8.35539  22.28235 1.000 60.17328  ? 7   GLU A OE1 1 
ATOM   33   O  OE2 . GLU A 1 11  ? -4.52329  -9.58970  24.02040 1.000 76.00045  ? 7   GLU A OE2 1 
ATOM   34   N  N   . GLN A 1 12  ? -8.93701  -8.55545  25.74767 1.000 54.38213  ? 8   GLN A N   1 
ATOM   35   C  CA  . GLN A 1 12  ? -10.19320 -9.00523  25.15551 1.000 56.73235  ? 8   GLN A CA  1 
ATOM   36   C  C   . GLN A 1 12  ? -11.28830 -7.95701  25.27903 1.000 58.94000  ? 8   GLN A C   1 
ATOM   37   O  O   . GLN A 1 12  ? -12.15249 -7.84607  24.40179 1.000 62.15568  ? 8   GLN A O   1 
ATOM   38   C  CB  . GLN A 1 12  ? -10.62273 -10.30494 25.83982 1.000 63.98209  ? 8   GLN A CB  1 
ATOM   39   C  CG  . GLN A 1 12  ? -12.06433 -10.71935 25.62956 1.000 66.88061  ? 8   GLN A CG  1 
ATOM   40   C  CD  . GLN A 1 12  ? -12.23289 -12.22411 25.64100 1.000 72.89014  ? 8   GLN A CD  1 
ATOM   41   O  OE1 . GLN A 1 12  ? -13.20102 -12.75611 25.09927 1.000 77.42206  ? 8   GLN A OE1 1 
ATOM   42   N  NE2 . GLN A 1 12  ? -11.28556 -12.92083 26.26121 1.000 72.17515  ? 8   GLN A NE2 1 
ATOM   43   N  N   . ILE A 1 13  ? -11.25158 -7.16856  26.34958 1.000 55.99443  ? 9   ILE A N   1 
ATOM   44   C  CA  . ILE A 1 13  ? -12.34743 -6.26532  26.67206 1.000 57.15793  ? 9   ILE A CA  1 
ATOM   45   C  C   . ILE A 1 13  ? -12.25897 -4.99594  25.83851 1.000 55.57040  ? 9   ILE A C   1 
ATOM   46   O  O   . ILE A 1 13  ? -13.24228 -4.56925  25.22247 1.000 50.08209  ? 9   ILE A O   1 
ATOM   47   C  CB  . ILE A 1 13  ? -12.32704 -5.96010  28.17912 1.000 58.06030  ? 9   ILE A CB  1 
ATOM   48   C  CG1 . ILE A 1 13  ? -13.00470 -7.09378  28.93923 1.000 57.56982  ? 9   ILE A CG1 1 
ATOM   49   C  CG2 . ILE A 1 13  ? -13.03034 -4.63980  28.46292 1.000 53.86490  ? 9   ILE A CG2 1 
ATOM   50   C  CD1 . ILE A 1 13  ? -13.27041 -6.78509  30.36998 1.000 55.52279  ? 9   ILE A CD1 1 
ATOM   51   N  N   . ALA A 1 14  ? -11.07787 -4.37675  25.80649 1.000 50.92674  ? 10  ALA A N   1 
ATOM   52   C  CA  . ALA A 1 14  ? -10.88903 -3.17292  25.01015 1.000 46.06812  ? 10  ALA A CA  1 
ATOM   53   C  C   . ALA A 1 14  ? -11.09406 -3.43339  23.52452 1.000 56.83807  ? 10  ALA A C   1 
ATOM   54   O  O   . ALA A 1 14  ? -11.42017 -2.50107  22.78112 1.000 52.17146  ? 10  ALA A O   1 
ATOM   55   C  CB  . ALA A 1 14  ? -9.49438  -2.59479  25.25634 1.000 54.51463  ? 10  ALA A CB  1 
ATOM   56   N  N   . GLU A 1 15  ? -10.91317 -4.67764  23.07560 1.000 49.95930  ? 11  GLU A N   1 
ATOM   57   C  CA  . GLU A 1 15  ? -11.21278 -5.01707  21.68939 1.000 56.70144  ? 11  GLU A CA  1 
ATOM   58   C  C   . GLU A 1 15  ? -12.70944 -5.20287  21.48076 1.000 55.81032  ? 11  GLU A C   1 
ATOM   59   O  O   . GLU A 1 15  ? -13.24636 -4.81711  20.43638 1.000 53.90501  ? 11  GLU A O   1 
ATOM   60   C  CB  . GLU A 1 15  ? -10.45475 -6.28211  21.28004 1.000 54.40399  ? 11  GLU A CB  1 
ATOM   61   C  CG  . GLU A 1 15  ? -9.04965  -6.05823  20.70461 1.000 62.63143  ? 11  GLU A CG  1 
ATOM   62   C  CD  . GLU A 1 15  ? -8.97329  -5.05867  19.55110 1.000 70.23755  ? 11  GLU A CD  1 
ATOM   63   O  OE1 . GLU A 1 15  ? -7.84029  -4.77700  19.10883 1.000 74.94433  ? 11  GLU A OE1 1 
ATOM   64   O  OE2 . GLU A 1 15  ? -10.01650 -4.59073  19.04410 1.000 64.22909  ? 11  GLU A OE2 1 
ATOM   65   N  N   . PHE A 1 16  ? -13.39488 -5.79522  22.46154 1.000 51.05646  ? 12  PHE A N   1 
ATOM   66   C  CA  . PHE A 1 16  ? -14.84943 -5.86132  22.41771 1.000 47.56634  ? 12  PHE A CA  1 
ATOM   67   C  C   . PHE A 1 16  ? -15.47538 -4.47662  22.47566 1.000 49.51480  ? 12  PHE A C   1 
ATOM   68   O  O   . PHE A 1 16  ? -16.60684 -4.29670  22.01293 1.000 44.27734  ? 12  PHE A O   1 
ATOM   69   C  CB  . PHE A 1 16  ? -15.37334 -6.71838  23.57176 1.000 49.91918  ? 12  PHE A CB  1 
ATOM   70   C  CG  . PHE A 1 16  ? -15.40999 -8.18862  23.26903 1.000 59.84884  ? 12  PHE A CG  1 
ATOM   71   C  CD1 . PHE A 1 16  ? -15.77310 -8.64279  22.01172 1.000 63.51702  ? 12  PHE A CD1 1 
ATOM   72   C  CD2 . PHE A 1 16  ? -15.08874 -9.11730  24.24473 1.000 62.11311  ? 12  PHE A CD2 1 
ATOM   73   C  CE1 . PHE A 1 16  ? -15.80898 -9.99692  21.73196 1.000 70.79157  ? 12  PHE A CE1 1 
ATOM   74   C  CE2 . PHE A 1 16  ? -15.12480 -10.47179 23.97212 1.000 65.21162  ? 12  PHE A CE2 1 
ATOM   75   C  CZ  . PHE A 1 16  ? -15.48432 -10.91236 22.71375 1.000 70.71588  ? 12  PHE A CZ  1 
ATOM   76   N  N   . LYS A 1 17  ? -14.76218 -3.49876  23.03789 1.000 47.63616  ? 13  LYS A N   1 
ATOM   77   C  CA  . LYS A 1 17  ? -15.23313 -2.12040  23.05231 1.000 40.65208  ? 13  LYS A CA  1 
ATOM   78   C  C   . LYS A 1 17  ? -14.99283 -1.43065  21.71533 1.000 46.69804  ? 13  LYS A C   1 
ATOM   79   O  O   . LYS A 1 17  ? -15.75882 -0.53729  21.33581 1.000 53.45742  ? 13  LYS A O   1 
ATOM   80   C  CB  . LYS A 1 17  ? -14.54706 -1.35621  24.18751 1.000 44.51579  ? 13  LYS A CB  1 
ATOM   81   C  CG  . LYS A 1 17  ? -14.94912 0.10232   24.32446 1.000 53.74589  ? 13  LYS A CG  1 
ATOM   82   C  CD  . LYS A 1 17  ? -14.50557 0.65825   25.67185 1.000 52.66102  ? 13  LYS A CD  1 
ATOM   83   C  CE  . LYS A 1 17  ? -14.51487 2.17875   25.68438 1.000 57.90296  ? 13  LYS A CE  1 
ATOM   84   N  NZ  . LYS A 1 17  ? -14.42081 2.74562   24.31126 1.000 66.20216  ? 13  LYS A NZ  1 
ATOM   85   N  N   . GLU A 1 18  ? -13.94512 -1.83257  20.99058 1.000 48.15611  ? 14  GLU A N   1 
ATOM   86   C  CA  . GLU A 1 18  ? -13.71170 -1.28642  19.65724 1.000 52.89216  ? 14  GLU A CA  1 
ATOM   87   C  C   . GLU A 1 18  ? -14.75364 -1.78800  18.66547 1.000 39.71591  ? 14  GLU A C   1 
ATOM   88   O  O   . GLU A 1 18  ? -15.22693 -1.02484  17.81517 1.000 50.96213  ? 14  GLU A O   1 
ATOM   89   C  CB  . GLU A 1 18  ? -12.30355 -1.64435  19.18127 1.000 53.06947  ? 14  GLU A CB  1 
ATOM   90   C  CG  . GLU A 1 18  ? -11.79030 -0.78537  18.03261 1.000 60.59167  ? 14  GLU A CG  1 
ATOM   91   C  CD  . GLU A 1 18  ? -11.61291 0.67185   18.41527 1.000 55.32996  ? 14  GLU A CD  1 
ATOM   92   O  OE1 . GLU A 1 18  ? -12.58455 1.44706   18.28462 1.000 61.33197  ? 14  GLU A OE1 1 
ATOM   93   O  OE2 . GLU A 1 18  ? -10.50059 1.04482   18.84203 1.000 60.27576  ? 14  GLU A OE2 1 
ATOM   94   N  N   . ALA A 1 19  ? -15.11767 -3.07014  18.75509 1.000 36.15396  ? 15  ALA A N   1 
ATOM   95   C  CA  . ALA A 1 19  ? -16.14586 -3.61328  17.87292 1.000 46.15601  ? 15  ALA A CA  1 
ATOM   96   C  C   . ALA A 1 19  ? -17.48003 -2.91214  18.08882 1.000 43.58685  ? 15  ALA A C   1 
ATOM   97   O  O   . ALA A 1 19  ? -18.19072 -2.60162  17.12597 1.000 40.28025  ? 15  ALA A O   1 
ATOM   98   C  CB  . ALA A 1 19  ? -16.28838 -5.11815  18.09710 1.000 42.05278  ? 15  ALA A CB  1 
ATOM   99   N  N   . PHE A 1 20  ? -17.83419 -2.65437  19.35058 1.000 39.87444  ? 16  PHE A N   1 
ATOM   100  C  CA  . PHE A 1 20  ? -19.05202 -1.91062  19.65449 1.000 41.63950  ? 16  PHE A CA  1 
ATOM   101  C  C   . PHE A 1 20  ? -19.04967 -0.53665  18.99854 1.000 40.50042  ? 16  PHE A C   1 
ATOM   102  O  O   . PHE A 1 20  ? -20.10730 -0.03772  18.59731 1.000 37.83190  ? 16  PHE A O   1 
ATOM   103  C  CB  . PHE A 1 20  ? -19.20674 -1.77347  21.17038 1.000 39.40658  ? 16  PHE A CB  1 
ATOM   104  C  CG  . PHE A 1 20  ? -20.55138 -1.26504  21.60450 1.000 37.96594  ? 16  PHE A CG  1 
ATOM   105  C  CD1 . PHE A 1 20  ? -21.62205 -2.13146  21.75586 1.000 35.69161  ? 16  PHE A CD1 1 
ATOM   106  C  CD2 . PHE A 1 20  ? -20.74493 0.08242   21.85933 1.000 32.03479  ? 16  PHE A CD2 1 
ATOM   107  C  CE1 . PHE A 1 20  ? -22.85950 -1.66174  22.16107 1.000 36.36506  ? 16  PHE A CE1 1 
ATOM   108  C  CE2 . PHE A 1 20  ? -21.97989 0.55802   22.25942 1.000 34.88460  ? 16  PHE A CE2 1 
ATOM   109  C  CZ  . PHE A 1 20  ? -23.03820 -0.31540  22.40961 1.000 37.18414  ? 16  PHE A CZ  1 
ATOM   110  N  N   . SER A 1 21  ? -17.87415 0.08309   18.87203 1.000 39.69710  ? 17  SER A N   1 
ATOM   111  C  CA  . SER A 1 21  ? -17.79784 1.43260   18.32458 1.000 37.11153  ? 17  SER A CA  1 
ATOM   112  C  C   . SER A 1 21  ? -18.04711 1.45380   16.82212 1.000 27.72104  ? 17  SER A C   1 
ATOM   113  O  O   . SER A 1 21  ? -18.53435 2.45984   16.29426 1.000 38.59921  ? 17  SER A O   1 
ATOM   114  C  CB  . SER A 1 21  ? -16.43624 2.04834   18.64511 1.000 37.18271  ? 17  SER A CB  1 
ATOM   115  O  OG  . SER A 1 21  ? -16.30357 2.28748   20.03503 1.000 48.80513  ? 17  SER A OG  1 
ATOM   116  N  N   . LEU A 1 22  ? -17.71500 0.36781   16.11815 1.000 37.50996  ? 18  LEU A N   1 
ATOM   117  C  CA  . LEU A 1 22  ? -17.96003 0.31923   14.67958 1.000 40.19266  ? 18  LEU A CA  1 
ATOM   118  C  C   . LEU A 1 22  ? -19.44986 0.38172   14.37251 1.000 41.63510  ? 18  LEU A C   1 
ATOM   119  O  O   . LEU A 1 22  ? -19.86291 0.99702   13.38281 1.000 44.31986  ? 18  LEU A O   1 
ATOM   120  C  CB  . LEU A 1 22  ? -17.35267 -0.94839  14.07936 1.000 45.83399  ? 18  LEU A CB  1 
ATOM   121  C  CG  . LEU A 1 22  ? -15.91654 -1.31143  14.45371 1.000 53.07015  ? 18  LEU A CG  1 
ATOM   122  C  CD1 . LEU A 1 22  ? -15.60022 -2.72106  13.98295 1.000 49.07843  ? 18  LEU A CD1 1 
ATOM   123  C  CD2 . LEU A 1 22  ? -14.93635 -0.31593  13.85852 1.000 55.38997  ? 18  LEU A CD2 1 
ATOM   124  N  N   . PHE A 1 23  ? -20.27222 -0.25290  15.20899 1.000 35.76498  ? 19  PHE A N   1 
ATOM   125  C  CA  . PHE A 1 23  ? -21.71119 -0.26204  14.97385 1.000 38.91595  ? 19  PHE A CA  1 
ATOM   126  C  C   . PHE A 1 23  ? -22.37907 0.98255   15.54478 1.000 37.90224  ? 19  PHE A C   1 
ATOM   127  O  O   . PHE A 1 23  ? -23.28944 1.54181   14.92325 1.000 33.07950  ? 19  PHE A O   1 
ATOM   128  C  CB  . PHE A 1 23  ? -22.32890 -1.52474  15.57396 1.000 34.23155  ? 19  PHE A CB  1 
ATOM   129  C  CG  . PHE A 1 23  ? -21.82228 -2.79681  14.95791 1.000 37.59966  ? 19  PHE A CG  1 
ATOM   130  C  CD1 . PHE A 1 23  ? -22.42455 -3.32458  13.82824 1.000 37.07988  ? 19  PHE A CD1 1 
ATOM   131  C  CD2 . PHE A 1 23  ? -20.74030 -3.46201  15.50625 1.000 35.52018  ? 19  PHE A CD2 1 
ATOM   132  C  CE1 . PHE A 1 23  ? -21.95744 -4.49433  13.26001 1.000 38.27482  ? 19  PHE A CE1 1 
ATOM   133  C  CE2 . PHE A 1 23  ? -20.26929 -4.63060  14.94266 1.000 42.88932  ? 19  PHE A CE2 1 
ATOM   134  C  CZ  . PHE A 1 23  ? -20.87812 -5.14735  13.81768 1.000 48.65689  ? 19  PHE A CZ  1 
ATOM   135  N  N   . ASP A 1 24  ? -21.94418 1.42834   16.72119 1.000 35.99295  ? 20  ASP A N   1 
ATOM   136  C  CA  . ASP A 1 24  ? -22.48406 2.63645   17.34242 1.000 36.45479  ? 20  ASP A CA  1 
ATOM   137  C  C   . ASP A 1 24  ? -21.81903 3.84142   16.68837 1.000 42.74383  ? 20  ASP A C   1 
ATOM   138  O  O   . ASP A 1 24  ? -20.79273 4.34256   17.15012 1.000 40.36464  ? 20  ASP A O   1 
ATOM   139  C  CB  . ASP A 1 24  ? -22.25886 2.61591   18.84948 1.000 40.24519  ? 20  ASP A CB  1 
ATOM   140  C  CG  . ASP A 1 24  ? -22.92111 3.78327   19.55166 1.000 39.56743  ? 20  ASP A CG  1 
ATOM   141  O  OD1 . ASP A 1 24  ? -23.80141 4.41862   18.93856 1.000 34.43171  ? 20  ASP A OD1 1 
ATOM   142  O  OD2 . ASP A 1 24  ? -22.56660 4.06526   20.71525 1.000 44.95843  ? 20  ASP A OD2 1 
ATOM   143  N  N   . LYS A 1 25  ? -22.41983 4.31510   15.59357 1.000 44.94733  ? 21  LYS A N   1 
ATOM   144  C  CA  . LYS A 1 25  ? -21.82889 5.41548   14.83703 1.000 39.49056  ? 21  LYS A CA  1 
ATOM   145  C  C   . LYS A 1 25  ? -21.84654 6.71255   15.63773 1.000 44.79101  ? 21  LYS A C   1 
ATOM   146  O  O   . LYS A 1 25  ? -20.82278 7.39631   15.75210 1.000 48.96151  ? 21  LYS A O   1 
ATOM   147  C  CB  . LYS A 1 25  ? -22.56190 5.59633   13.50589 1.000 40.07792  ? 21  LYS A CB  1 
ATOM   148  C  CG  . LYS A 1 25  ? -22.89455 4.29752   12.78527 1.000 39.91139  ? 21  LYS A CG  1 
ATOM   149  C  CD  . LYS A 1 25  ? -21.64256 3.48613   12.48369 1.000 36.80072  ? 21  LYS A CD  1 
ATOM   150  C  CE  . LYS A 1 25  ? -21.20665 3.64483   11.03510 1.000 33.85242  ? 21  LYS A CE  1 
ATOM   151  N  NZ  . LYS A 1 25  ? -19.99287 2.83584   10.72565 1.000 35.43002  ? 21  LYS A NZ  1 
ATOM   152  N  N   . ASP A 1 26  ? -23.00127 7.07128   16.19999 1.000 41.59469  ? 22  ASP A N   1 
ATOM   153  C  CA  . ASP A 1 26  ? -23.11724 8.33228   16.92206 1.000 46.34166  ? 22  ASP A CA  1 
ATOM   154  C  C   . ASP A 1 26  ? -22.48171 8.29439   18.30808 1.000 48.35333  ? 22  ASP A C   1 
ATOM   155  O  O   . ASP A 1 26  ? -22.39253 9.34204   18.95690 1.000 53.66889  ? 22  ASP A O   1 
ATOM   156  C  CB  . ASP A 1 26  ? -24.59192 8.75297   17.00863 1.000 47.71749  ? 22  ASP A CB  1 
ATOM   157  C  CG  . ASP A 1 26  ? -25.40590 7.89053   17.95943 1.000 37.28353  ? 22  ASP A CG  1 
ATOM   158  O  OD1 . ASP A 1 26  ? -24.90102 6.85180   18.42968 1.000 42.51146  ? 22  ASP A OD1 1 
ATOM   159  O  OD2 . ASP A 1 26  ? -26.56583 8.25826   18.23808 1.000 50.13372  ? 22  ASP A OD2 1 
ATOM   160  N  N   . GLY A 1 27  ? -22.04229 7.12585   18.77221 1.000 51.14800  ? 23  GLY A N   1 
ATOM   161  C  CA  . GLY A 1 27  ? -21.30894 7.03486   20.02024 1.000 50.07520  ? 23  GLY A CA  1 
ATOM   162  C  C   . GLY A 1 27  ? -22.10050 7.33521   21.27077 1.000 54.71174  ? 23  GLY A C   1 
ATOM   163  O  O   . GLY A 1 27  ? -21.51308 7.72916   22.28102 1.000 61.56667  ? 23  GLY A O   1 
ATOM   164  N  N   . ASP A 1 28  ? -23.41792 7.15707   21.24018 1.000 50.75306  ? 24  ASP A N   1 
ATOM   165  C  CA  . ASP A 1 28  ? -24.26220 7.41700   22.39808 1.000 44.15486  ? 24  ASP A CA  1 
ATOM   166  C  C   . ASP A 1 28  ? -24.38731 6.21428   23.32856 1.000 47.23252  ? 24  ASP A C   1 
ATOM   167  O  O   . ASP A 1 28  ? -25.18262 6.25756   24.27294 1.000 51.56939  ? 24  ASP A O   1 
ATOM   168  C  CB  . ASP A 1 28  ? -25.65180 7.88357   21.94369 1.000 49.38944  ? 24  ASP A CB  1 
ATOM   169  C  CG  . ASP A 1 28  ? -26.51110 6.75038   21.40509 1.000 45.92769  ? 24  ASP A CG  1 
ATOM   170  O  OD1 . ASP A 1 28  ? -25.95860 5.70198   21.00595 1.000 40.84787  ? 24  ASP A OD1 1 
ATOM   171  O  OD2 . ASP A 1 28  ? -27.75004 6.90892   21.38662 1.000 42.38392  ? 24  ASP A OD2 1 
ATOM   172  N  N   . GLY A 1 29  ? -23.62685 5.14940   23.08520 1.000 37.98133  ? 25  GLY A N   1 
ATOM   173  C  CA  . GLY A 1 29  ? -23.70492 3.95921   23.90601 1.000 42.92629  ? 25  GLY A CA  1 
ATOM   174  C  C   . GLY A 1 29  ? -24.80581 2.99046   23.53799 1.000 49.81783  ? 25  GLY A C   1 
ATOM   175  O  O   . GLY A 1 29  ? -25.01081 2.00869   24.26129 1.000 38.08510  ? 25  GLY A O   1 
ATOM   176  N  N   . THR A 1 30  ? -25.52849 3.23513   22.44498 1.000 43.20385  ? 26  THR A N   1 
ATOM   177  C  CA  . THR A 1 30  ? -26.59908 2.35899   21.98798 1.000 38.49688  ? 26  THR A CA  1 
ATOM   178  C  C   . THR A 1 30  ? -26.44558 2.09763   20.49715 1.000 36.29105  ? 26  THR A C   1 
ATOM   179  O  O   . THR A 1 30  ? -26.05223 2.98937   19.74049 1.000 40.88836  ? 26  THR A O   1 
ATOM   180  C  CB  . THR A 1 30  ? -27.99044 2.96466   22.25248 1.000 41.91662  ? 26  THR A CB  1 
ATOM   181  O  OG1 . THR A 1 30  ? -28.23798 4.02514   21.32062 1.000 44.29573  ? 26  THR A OG1 1 
ATOM   182  C  CG2 . THR A 1 30  ? -28.09687 3.50385   23.67288 1.000 51.78434  ? 26  THR A CG2 1 
ATOM   183  N  N   . ILE A 1 31  ? -26.76266 0.87601   20.07741 1.000 35.03599  ? 27  ILE A N   1 
ATOM   184  C  CA  . ILE A 1 31  ? -26.79770 0.50897   18.66574 1.000 32.65588  ? 27  ILE A CA  1 
ATOM   185  C  C   . ILE A 1 31  ? -28.25701 0.39549   18.25001 1.000 34.62658  ? 27  ILE A C   1 
ATOM   186  O  O   . ILE A 1 31  ? -29.00154 -0.43305  18.78890 1.000 33.53227  ? 27  ILE A O   1 
ATOM   187  C  CB  . ILE A 1 31  ? -26.04442 -0.80091  18.39024 1.000 32.51006  ? 27  ILE A CB  1 
ATOM   188  C  CG1 . ILE A 1 31  ? -24.56343 -0.65543  18.74142 1.000 32.37169  ? 27  ILE A CG1 1 
ATOM   189  C  CG2 . ILE A 1 31  ? -26.20694 -1.21005  16.93367 1.000 33.74592  ? 27  ILE A CG2 1 
ATOM   190  C  CD1 . ILE A 1 31  ? -23.84097 -1.97792  18.86165 1.000 30.48997  ? 27  ILE A CD1 1 
ATOM   191  N  N   . THR A 1 32  ? -28.66512 1.22278   17.29530 1.000 30.30469  ? 28  THR A N   1 
ATOM   192  C  CA  . THR A 1 32  ? -30.03373 1.23102   16.80487 1.000 26.97987  ? 28  THR A CA  1 
ATOM   193  C  C   . THR A 1 32  ? -30.15123 0.39713   15.53265 1.000 29.30815  ? 28  THR A C   1 
ATOM   194  O  O   . THR A 1 32  ? -29.16395 -0.09074  14.97801 1.000 25.62686  ? 28  THR A O   1 
ATOM   195  C  CB  . THR A 1 32  ? -30.50572 2.66478   16.54578 1.000 27.74081  ? 28  THR A CB  1 
ATOM   196  O  OG1 . THR A 1 32  ? -29.80675 3.20351   15.41637 1.000 26.79920  ? 28  THR A OG1 1 
ATOM   197  C  CG2 . THR A 1 32  ? -30.24389 3.53973   17.76346 1.000 31.06146  ? 28  THR A CG2 1 
ATOM   198  N  N   . THR A 1 33  ? -31.39393 0.23129   15.07560 1.000 22.12633  ? 29  THR A N   1 
ATOM   199  C  CA  . THR A 1 33  ? -31.63294 -0.48759  13.82936 1.000 22.14778  ? 29  THR A CA  1 
ATOM   200  C  C   . THR A 1 33  ? -31.09491 0.27837   12.62914 1.000 25.56117  ? 29  THR A C   1 
ATOM   201  O  O   . THR A 1 33  ? -30.66178 -0.33536  11.64779 1.000 20.97612  ? 29  THR A O   1 
ATOM   202  C  CB  . THR A 1 33  ? -33.12786 -0.75554  13.65455 1.000 22.26593  ? 29  THR A CB  1 
ATOM   203  O  OG1 . THR A 1 33  ? -33.85125 0.47764   13.77450 1.000 23.35120  ? 29  THR A OG1 1 
ATOM   204  C  CG2 . THR A 1 33  ? -33.62365 -1.73447  14.70994 1.000 23.52384  ? 29  THR A CG2 1 
ATOM   205  N  N   . LYS A 1 34  ? -31.11285 1.61106   12.68898 1.000 24.91130  ? 30  LYS A N   1 
ATOM   206  C  CA  . LYS A 1 34  ? -30.57953 2.40779   11.58959 1.000 26.73940  ? 30  LYS A CA  1 
ATOM   207  C  C   . LYS A 1 34  ? -29.06085 2.30759   11.52538 1.000 23.67601  ? 30  LYS A C   1 
ATOM   208  O  O   . LYS A 1 34  ? -28.47928 2.26858   10.43425 1.000 26.45509  ? 30  LYS A O   1 
ATOM   209  C  CB  . LYS A 1 34  ? -31.01674 3.86505   11.73890 1.000 22.40024  ? 30  LYS A CB  1 
ATOM   210  C  CG  . LYS A 1 34  ? -32.49943 4.09532   11.49890 1.000 23.36380  ? 30  LYS A CG  1 
ATOM   211  C  CD  . LYS A 1 34  ? -32.81452 5.57740   11.37393 1.000 24.83524  ? 30  LYS A CD  1 
ATOM   212  C  CE  . LYS A 1 34  ? -32.69664 6.28259   12.71718 1.000 22.85879  ? 30  LYS A CE  1 
ATOM   213  N  NZ  . LYS A 1 34  ? -33.57710 5.66315   13.74904 1.000 23.70976  ? 30  LYS A NZ  1 
ATOM   214  N  N   . GLU A 1 35  ? -28.40251 2.26654   12.68519 1.000 21.56599  ? 31  GLU A N   1 
ATOM   215  C  CA  . GLU A 1 35  ? -26.95250 2.11261   12.70655 1.000 23.10353  ? 31  GLU A CA  1 
ATOM   216  C  C   . GLU A 1 35  ? -26.54361 0.72742   12.22497 1.000 21.74357  ? 31  GLU A C   1 
ATOM   217  O  O   . GLU A 1 35  ? -25.52926 0.57748   11.53391 1.000 30.69580  ? 31  GLU A O   1 
ATOM   218  C  CB  . GLU A 1 35  ? -26.42285 2.37541   14.11527 1.000 30.14054  ? 31  GLU A CB  1 
ATOM   219  C  CG  . GLU A 1 35  ? -26.40193 3.84633   14.49324 1.000 30.70511  ? 31  GLU A CG  1 
ATOM   220  C  CD  . GLU A 1 35  ? -25.94015 4.07552   15.91612 1.000 35.12364  ? 31  GLU A CD  1 
ATOM   221  O  OE1 . GLU A 1 35  ? -26.32541 3.28194   16.80032 1.000 27.29320  ? 31  GLU A OE1 1 
ATOM   222  O  OE2 . GLU A 1 35  ? -25.19759 5.05229   16.15128 1.000 32.82902  ? 31  GLU A OE2 1 
ATOM   223  N  N   . LEU A 1 36  ? -27.32762 -0.29476  12.57529 1.000 25.04443  ? 32  LEU A N   1 
ATOM   224  C  CA  . LEU A 1 36  ? -27.04911 -1.64682  12.10383 1.000 23.22562  ? 32  LEU A CA  1 
ATOM   225  C  C   . LEU A 1 36  ? -27.23863 -1.75590  10.59599 1.000 26.21138  ? 32  LEU A C   1 
ATOM   226  O  O   . LEU A 1 36  ? -26.41663 -2.36792  9.90429  1.000 21.15028  ? 32  LEU A O   1 
ATOM   227  C  CB  . LEU A 1 36  ? -27.94915 -2.64435  12.83159 1.000 26.79256  ? 32  LEU A CB  1 
ATOM   228  C  CG  . LEU A 1 36  ? -27.34288 -3.97178  13.28584 1.000 41.41804  ? 32  LEU A CG  1 
ATOM   229  C  CD1 . LEU A 1 36  ? -25.99999 -3.76355  13.97097 1.000 32.12179  ? 32  LEU A CD1 1 
ATOM   230  C  CD2 . LEU A 1 36  ? -28.31394 -4.69317  14.20337 1.000 28.89700  ? 32  LEU A CD2 1 
ATOM   231  N  N   . GLY A 1 37  ? -28.31896 -1.17354  10.06910 1.000 27.09328  ? 33  GLY A N   1 
ATOM   232  C  CA  . GLY A 1 37  ? -28.53189 -1.19313  8.63220  1.000 23.15103  ? 33  GLY A CA  1 
ATOM   233  C  C   . GLY A 1 37  ? -27.45808 -0.44849  7.86581  1.000 23.55986  ? 33  GLY A C   1 
ATOM   234  O  O   . GLY A 1 37  ? -27.12881 -0.81466  6.73506  1.000 26.25245  ? 33  GLY A O   1 
ATOM   235  N  N   . THR A 1 38  ? -26.89522 0.60058   8.46732  1.000 23.18402  ? 34  THR A N   1 
ATOM   236  C  CA  . THR A 1 38  ? -25.80904 1.33052   7.82246  1.000 18.04249  ? 34  THR A CA  1 
ATOM   237  C  C   . THR A 1 38  ? -24.54770 0.47971   7.73805  1.000 21.61478  ? 34  THR A C   1 
ATOM   238  O  O   . THR A 1 38  ? -23.87249 0.45962   6.70177  1.000 18.18689  ? 34  THR A O   1 
ATOM   239  C  CB  . THR A 1 38  ? -25.52993 2.62832   8.58049  1.000 27.82559  ? 34  THR A CB  1 
ATOM   240  O  OG1 . THR A 1 38  ? -26.65588 3.50682   8.45570  1.000 32.86612  ? 34  THR A OG1 1 
ATOM   241  C  CG2 . THR A 1 38  ? -24.28865 3.31483   8.03129  1.000 24.63118  ? 34  THR A CG2 1 
ATOM   242  N  N   . VAL A 1 39  ? -24.21664 -0.23142  8.81782  1.000 19.58126  ? 35  VAL A N   1 
ATOM   243  C  CA  . VAL A 1 39  ? -23.04154 -1.09986  8.80904  1.000 25.24027  ? 35  VAL A CA  1 
ATOM   244  C  C   . VAL A 1 39  ? -23.22333 -2.22938  7.80349  1.000 18.96925  ? 35  VAL A C   1 
ATOM   245  O  O   . VAL A 1 39  ? -22.36574 -2.46256  6.94360  1.000 24.22379  ? 35  VAL A O   1 
ATOM   246  C  CB  . VAL A 1 39  ? -22.76498 -1.64574  10.22110 1.000 23.27908  ? 35  VAL A CB  1 
ATOM   247  C  CG1 . VAL A 1 39  ? -21.67900 -2.70790  10.17117 1.000 22.52407  ? 35  VAL A CG1 1 
ATOM   248  C  CG2 . VAL A 1 39  ? -22.36937 -0.51833  11.15775 1.000 24.56162  ? 35  VAL A CG2 1 
HETATM 249  N  N   . MSE A 1 40  ? -24.34025 -2.94687  7.90067  1.000 20.27954  ? 36  MSE A N   1 
HETATM 250  C  CA  . MSE A 1 40  ? -24.62928 -4.07736  7.02061  1.000 19.12219  ? 36  MSE A CA  1 
HETATM 251  C  C   . MSE A 1 40  ? -24.54576 -3.70649  5.54277  1.000 21.48573  ? 36  MSE A C   1 
HETATM 252  O  O   . MSE A 1 40  ? -24.00091 -4.46087  4.73746  1.000 26.00219  ? 36  MSE A O   1 
HETATM 253  C  CB  . MSE A 1 40  ? -26.01447 -4.65052  7.33242  1.000 23.11692  ? 36  MSE A CB  1 
HETATM 254  C  CG  . MSE A 1 40  ? -26.10366 -5.38075  8.66149  1.000 28.94257  ? 36  MSE A CG  1 
HETATM 255  SE SE  . MSE A 1 40  ? -24.58658 -6.56913  8.96011  1.000 53.45070  ? 36  MSE A SE  1 
HETATM 256  C  CE  . MSE A 1 40  ? -24.59270 -6.58436  10.91137 1.000 41.42540  ? 36  MSE A CE  1 
ATOM   257  N  N   . ARG A 1 41  ? -25.08612 -2.53808  5.19012  1.000 18.62275  ? 37  ARG A N   1 
ATOM   258  C  CA  . ARG A 1 41  ? -25.02182 -2.09581  3.80160  1.000 22.19711  ? 37  ARG A CA  1 
ATOM   259  C  C   . ARG A 1 41  ? -23.60140 -1.72707  3.39365  1.000 20.23465  ? 37  ARG A C   1 
ATOM   260  O  O   . ARG A 1 41  ? -23.21077 -1.95360  2.24265  1.000 23.23601  ? 37  ARG A O   1 
ATOM   261  C  CB  . ARG A 1 41  ? -25.97441 -0.92121  3.57919  1.000 15.88096  ? 37  ARG A CB  1 
ATOM   262  C  CG  . ARG A 1 41  ? -27.44168 -1.32174  3.60452  1.000 23.82567  ? 37  ARG A CG  1 
ATOM   263  C  CD  . ARG A 1 41  ? -28.32888 -0.20370  3.08530  1.000 19.91987  ? 37  ARG A CD  1 
ATOM   264  N  NE  . ARG A 1 41  ? -28.40611 0.90469   4.02885  1.000 17.36344  ? 37  ARG A NE  1 
ATOM   265  C  CZ  . ARG A 1 41  ? -29.17425 0.90930   5.10928  1.000 19.30151  ? 37  ARG A CZ  1 
ATOM   266  N  NH1 . ARG A 1 41  ? -29.94732 -0.12089  5.41135  1.000 19.15281  ? 37  ARG A NH1 1 
ATOM   267  N  NH2 . ARG A 1 41  ? -29.16722 1.97365   5.90627  1.000 21.88662  ? 37  ARG A NH2 1 
ATOM   268  N  N   . SER A 1 42  ? -22.81245 -1.17010  4.31429  1.000 18.42650  ? 38  SER A N   1 
ATOM   269  C  CA  . SER A 1 42  ? -21.40626 -0.92592  4.01815  1.000 22.38141  ? 38  SER A CA  1 
ATOM   270  C  C   . SER A 1 42  ? -20.62460 -2.22393  3.86405  1.000 29.07808  ? 38  SER A C   1 
ATOM   271  O  O   . SER A 1 42  ? -19.51042 -2.20399  3.32998  1.000 22.61065  ? 38  SER A O   1 
ATOM   272  C  CB  . SER A 1 42  ? -20.77603 -0.05966  5.10906  1.000 26.01525  ? 38  SER A CB  1 
ATOM   273  O  OG  . SER A 1 42  ? -20.81756 -0.71122  6.36500  1.000 28.68484  ? 38  SER A OG  1 
ATOM   274  N  N   . LEU A 1 43  ? -21.18546 -3.34699  4.31555  1.000 25.68134  ? 39  LEU A N   1 
ATOM   275  C  CA  . LEU A 1 43  ? -20.58485 -4.66269  4.14639  1.000 29.75980  ? 39  LEU A CA  1 
ATOM   276  C  C   . LEU A 1 43  ? -21.22871 -5.45337  3.01133  1.000 28.69332  ? 39  LEU A C   1 
ATOM   277  O  O   . LEU A 1 43  ? -21.10589 -6.68189  2.97172  1.000 30.85057  ? 39  LEU A O   1 
ATOM   278  C  CB  . LEU A 1 43  ? -20.66553 -5.45437  5.45344  1.000 20.81082  ? 39  LEU A CB  1 
ATOM   279  C  CG  . LEU A 1 43  ? -20.09713 -4.81207  6.72170  1.000 24.90975  ? 39  LEU A CG  1 
ATOM   280  C  CD1 . LEU A 1 43  ? -19.84338 -5.87189  7.77841  1.000 30.44590  ? 39  LEU A CD1 1 
ATOM   281  C  CD2 . LEU A 1 43  ? -18.81447 -4.05148  6.41984  1.000 28.34230  ? 39  LEU A CD2 1 
ATOM   282  N  N   . GLY A 1 44  ? -21.91651 -4.77652  2.09326  1.000 27.76030  ? 40  GLY A N   1 
ATOM   283  C  CA  . GLY A 1 44  ? -22.50556 -5.42868  0.94260  1.000 28.22058  ? 40  GLY A CA  1 
ATOM   284  C  C   . GLY A 1 44  ? -23.80179 -6.16437  1.19794  1.000 27.32564  ? 40  GLY A C   1 
ATOM   285  O  O   . GLY A 1 44  ? -24.31034 -6.81985  0.27998  1.000 23.00971  ? 40  GLY A O   1 
ATOM   286  N  N   . GLN A 1 45  ? -24.35255 -6.08573  2.40273  1.000 26.70654  ? 41  GLN A N   1 
ATOM   287  C  CA  . GLN A 1 45  ? -25.61590 -6.73149  2.72287  1.000 35.00805  ? 41  GLN A CA  1 
ATOM   288  C  C   . GLN A 1 45  ? -26.76801 -5.74151  2.57764  1.000 21.23871  ? 41  GLN A C   1 
ATOM   289  O  O   . GLN A 1 45  ? -26.57249 -4.53600  2.41765  1.000 23.26702  ? 41  GLN A O   1 
ATOM   290  C  CB  . GLN A 1 45  ? -25.57778 -7.31133  4.13987  1.000 30.35580  ? 41  GLN A CB  1 
ATOM   291  C  CG  . GLN A 1 45  ? -24.24204 -7.93639  4.51087  1.000 30.63118  ? 41  GLN A CG  1 
ATOM   292  C  CD  . GLN A 1 45  ? -23.84978 -9.06542  3.57797  1.000 27.30494  ? 41  GLN A CD  1 
ATOM   293  O  OE1 . GLN A 1 45  ? -24.57477 -10.05082 3.43947  1.000 35.94093  ? 41  GLN A OE1 1 
ATOM   294  N  NE2 . GLN A 1 45  ? -22.70141 -8.92426  2.92710  1.000 31.24022  ? 41  GLN A NE2 1 
ATOM   295  N  N   . ASN A 1 46  ? -27.98739 -6.27012  2.62975  1.000 17.73143  ? 42  ASN A N   1 
ATOM   296  C  CA  . ASN A 1 46  ? -29.19526 -5.44622  2.55065  1.000 25.90136  ? 42  ASN A CA  1 
ATOM   297  C  C   . ASN A 1 46  ? -30.29158 -6.07944  3.38967  1.000 28.93762  ? 42  ASN A C   1 
ATOM   298  O  O   . ASN A 1 46  ? -31.23021 -6.69329  2.86489  1.000 21.37224  ? 42  ASN A O   1 
ATOM   299  C  CB  . ASN A 1 46  ? -29.65317 -5.26897  1.10297  1.000 26.11135  ? 42  ASN A CB  1 
ATOM   300  C  CG  . ASN A 1 46  ? -30.66139 -4.14855  0.94871  1.000 39.10951  ? 42  ASN A CG  1 
ATOM   301  O  OD1 . ASN A 1 46  ? -30.86797 -3.35584  1.86854  1.000 30.78511  ? 42  ASN A OD1 1 
ATOM   302  N  ND2 . ASN A 1 46  ? -31.29989 -4.07935  -0.21409 1.000 34.21879  ? 42  ASN A ND2 1 
ATOM   303  N  N   . PRO A 1 47  ? -30.20814 -5.95044  4.71214  1.000 23.67549  ? 43  PRO A N   1 
ATOM   304  C  CA  . PRO A 1 47  ? -31.28490 -6.45749  5.56514  1.000 23.34792  ? 43  PRO A CA  1 
ATOM   305  C  C   . PRO A 1 47  ? -32.51116 -5.56359  5.48895  1.000 31.23661  ? 43  PRO A C   1 
ATOM   306  O  O   . PRO A 1 47  ? -32.41509 -4.35017  5.29034  1.000 21.43384  ? 43  PRO A O   1 
ATOM   307  C  CB  . PRO A 1 47  ? -30.66587 -6.43200  6.96650  1.000 24.88027  ? 43  PRO A CB  1 
ATOM   308  C  CG  . PRO A 1 47  ? -29.67339 -5.31394  6.89397  1.000 19.26060  ? 43  PRO A CG  1 
ATOM   309  C  CD  . PRO A 1 47  ? -29.09216 -5.40272  5.50542  1.000 19.78150  ? 43  PRO A CD  1 
ATOM   310  N  N   . THR A 1 48  ? -33.67704 -6.18423  5.63895  1.000 28.86762  ? 44  THR A N   1 
ATOM   311  C  CA  . THR A 1 48  ? -34.92357 -5.44022  5.68840  1.000 24.74355  ? 44  THR A CA  1 
ATOM   312  C  C   . THR A 1 48  ? -35.08862 -4.78324  7.05701  1.000 26.92241  ? 44  THR A C   1 
ATOM   313  O  O   . THR A 1 48  ? -34.29793 -4.99653  7.97967  1.000 28.65979  ? 44  THR A O   1 
ATOM   314  C  CB  . THR A 1 48  ? -36.10899 -6.35765  5.39641  1.000 33.21372  ? 44  THR A CB  1 
ATOM   315  O  OG1 . THR A 1 48  ? -36.25521 -7.29973  6.46620  1.000 26.33403  ? 44  THR A OG1 1 
ATOM   316  C  CG2 . THR A 1 48  ? -35.88973 -7.11194  4.09380  1.000 26.78804  ? 44  THR A CG2 1 
ATOM   317  N  N   . GLU A 1 49  ? -36.13783 -3.96810  7.18539  1.000 27.86230  ? 45  GLU A N   1 
ATOM   318  C  CA  . GLU A 1 49  ? -36.40486 -3.33277  8.47065  1.000 24.30124  ? 45  GLU A CA  1 
ATOM   319  C  C   . GLU A 1 49  ? -36.80382 -4.35938  9.52152  1.000 24.53168  ? 45  GLU A C   1 
ATOM   320  O  O   . GLU A 1 49  ? -36.50770 -4.17763  10.70745 1.000 24.22864  ? 45  GLU A O   1 
ATOM   321  C  CB  . GLU A 1 49  ? -37.48824 -2.25803  8.32659  1.000 22.78406  ? 45  GLU A CB  1 
ATOM   322  C  CG  . GLU A 1 49  ? -38.90496 -2.78525  8.11082  1.000 31.72416  ? 45  GLU A CG  1 
ATOM   323  C  CD  . GLU A 1 49  ? -39.11216 -3.40232  6.74183  1.000 34.06060  ? 45  GLU A CD  1 
ATOM   324  O  OE1 . GLU A 1 49  ? -39.48334 -2.66680  5.80289  1.000 37.21037  ? 45  GLU A OE1 1 
ATOM   325  O  OE2 . GLU A 1 49  ? -38.90630 -4.62705  6.60313  1.000 33.52063  ? 45  GLU A OE2 1 
ATOM   326  N  N   . ALA A 1 50  ? -37.45934 -5.44433  9.10718  1.000 26.88748  ? 46  ALA A N   1 
ATOM   327  C  CA  . ALA A 1 50  ? -37.84989 -6.48336  10.05094 1.000 27.54736  ? 46  ALA A CA  1 
ATOM   328  C  C   . ALA A 1 50  ? -36.66214 -7.35138  10.44621 1.000 25.68324  ? 46  ALA A C   1 
ATOM   329  O  O   . ALA A 1 50  ? -36.51971 -7.71417  11.61941 1.000 28.82467  ? 46  ALA A O   1 
ATOM   330  C  CB  . ALA A 1 50  ? -38.96719 -7.34058  9.45416  1.000 24.63994  ? 46  ALA A CB  1 
ATOM   331  N  N   . GLU A 1 51  ? -35.80637 -7.69759  9.48078  1.000 23.21521  ? 47  GLU A N   1 
ATOM   332  C  CA  . GLU A 1 51  ? -34.60700 -8.46683  9.79612  1.000 30.83431  ? 47  GLU A CA  1 
ATOM   333  C  C   . GLU A 1 51  ? -33.70044 -7.69770  10.74600 1.000 32.14539  ? 47  GLU A C   1 
ATOM   334  O  O   . GLU A 1 51  ? -33.04701 -8.29095  11.61206 1.000 34.45846  ? 47  GLU A O   1 
ATOM   335  C  CB  . GLU A 1 51  ? -33.85615 -8.82251  8.51225  1.000 24.95347  ? 47  GLU A CB  1 
ATOM   336  C  CG  . GLU A 1 51  ? -34.55579 -9.85431  7.64170  1.000 23.09565  ? 47  GLU A CG  1 
ATOM   337  C  CD  . GLU A 1 51  ? -33.93823 -9.96713  6.25957  1.000 32.48893  ? 47  GLU A CD  1 
ATOM   338  O  OE1 . GLU A 1 51  ? -33.32207 -8.98366  5.79819  1.000 27.89664  ? 47  GLU A OE1 1 
ATOM   339  O  OE2 . GLU A 1 51  ? -34.06924 -11.03984 5.63326  1.000 38.12513  ? 47  GLU A OE2 1 
ATOM   340  N  N   . LEU A 1 52  ? -33.65233 -6.37186  10.60026 1.000 31.56451  ? 48  LEU A N   1 
ATOM   341  C  CA  . LEU A 1 52  ? -32.83120 -5.55817  11.48898 1.000 32.98819  ? 48  LEU A CA  1 
ATOM   342  C  C   . LEU A 1 52  ? -33.39884 -5.54749  12.90153 1.000 30.87826  ? 48  LEU A C   1 
ATOM   343  O  O   . LEU A 1 52  ? -32.64942 -5.65209  13.87973 1.000 29.07191  ? 48  LEU A O   1 
ATOM   344  C  CB  . LEU A 1 52  ? -32.72645 -4.13700  10.94122 1.000 21.85263  ? 48  LEU A CB  1 
ATOM   345  C  CG  . LEU A 1 52  ? -31.64920 -3.91710  9.87988  1.000 26.59785  ? 48  LEU A CG  1 
ATOM   346  C  CD1 . LEU A 1 52  ? -31.83625 -2.56376  9.21403  1.000 28.16459  ? 48  LEU A CD1 1 
ATOM   347  C  CD2 . LEU A 1 52  ? -30.25611 -4.04708  10.47404 1.000 24.84746  ? 48  LEU A CD2 1 
ATOM   348  N  N   . GLN A 1 53  ? -34.72252 -5.42191  13.02642 1.000 21.81739  ? 49  GLN A N   1 
ATOM   349  C  CA  . GLN A 1 53  ? -35.34945 -5.47797  14.34159 1.000 28.76025  ? 49  GLN A CA  1 
ATOM   350  C  C   . GLN A 1 53  ? -35.18858 -6.85237  14.97513 1.000 35.57139  ? 49  GLN A C   1 
ATOM   351  O  O   . GLN A 1 53  ? -35.07135 -6.96048  16.20082 1.000 33.76218  ? 49  GLN A O   1 
ATOM   352  C  CB  . GLN A 1 53  ? -36.83179 -5.11668  14.23476 1.000 33.33105  ? 49  GLN A CB  1 
ATOM   353  C  CG  . GLN A 1 53  ? -37.09913 -3.66409  13.88195 1.000 31.35108  ? 49  GLN A CG  1 
ATOM   354  C  CD  . GLN A 1 53  ? -38.57705 -3.37417  13.70470 1.000 39.74675  ? 49  GLN A CD  1 
ATOM   355  O  OE1 . GLN A 1 53  ? -39.25257 -4.00549  12.89152 1.000 35.24648  ? 49  GLN A OE1 1 
ATOM   356  N  NE2 . GLN A 1 53  ? -39.08682 -2.41331  14.46587 1.000 24.88443  ? 49  GLN A NE2 1 
ATOM   357  N  N   . ASP A 1 54  ? -35.18291 -7.91064  14.15996 1.000 36.83653  ? 50  ASP A N   1 
ATOM   358  C  CA  . ASP A 1 54  ? -35.00851 -9.25755  14.69340 1.000 44.83253  ? 50  ASP A CA  1 
ATOM   359  C  C   . ASP A 1 54  ? -33.61656 -9.44185  15.28265 1.000 42.52745  ? 50  ASP A C   1 
ATOM   360  O  O   . ASP A 1 54  ? -33.46454 -10.05592 16.34444 1.000 42.52321  ? 50  ASP A O   1 
ATOM   361  C  CB  . ASP A 1 54  ? -35.27001 -10.29299 13.60006 1.000 45.81870  ? 50  ASP A CB  1 
ATOM   362  C  CG  . ASP A 1 54  ? -36.65530 -10.89929 13.69299 1.000 58.38284  ? 50  ASP A CG  1 
ATOM   363  O  OD1 . ASP A 1 54  ? -37.28989 -11.10448 12.63737 1.000 47.33026  ? 50  ASP A OD1 1 
ATOM   364  O  OD2 . ASP A 1 54  ? -37.11129 -11.16999 14.82500 1.000 59.59945  ? 50  ASP A OD2 1 
HETATM 365  N  N   . MSE A 1 55  ? -32.59445 -8.92265  14.60666 1.000 44.95488  ? 51  MSE A N   1 
HETATM 366  C  CA  . MSE A 1 55  ? -31.22248 -8.95005  15.10522 1.000 46.63057  ? 51  MSE A CA  1 
HETATM 367  C  C   . MSE A 1 55  ? -31.15561 -8.34318  16.49909 1.000 46.73427  ? 51  MSE A C   1 
HETATM 368  O  O   . MSE A 1 55  ? -30.49897 -8.87335  17.39551 1.000 40.45618  ? 51  MSE A O   1 
HETATM 369  C  CB  . MSE A 1 55  ? -30.29412 -8.18427  14.16245 1.000 43.05493  ? 51  MSE A CB  1 
HETATM 370  C  CG  . MSE A 1 55  ? -29.83915 -8.96027  12.94116 1.000 44.49037  ? 51  MSE A CG  1 
HETATM 371  SE SE  . MSE A 1 55  ? -28.74823 -7.85182  11.76359 1.000 63.95737  ? 51  MSE A SE  1 
HETATM 372  C  CE  . MSE A 1 55  ? -29.23341 -8.65197  10.05355 1.000 33.66319  ? 51  MSE A CE  1 
ATOM   373  N  N   . ILE A 1 56  ? -31.85132 -7.21726  16.66424 1.000 38.20685  ? 52  ILE A N   1 
ATOM   374  C  CA  . ILE A 1 56  ? -31.89515 -6.54974  17.95940 1.000 36.09784  ? 52  ILE A CA  1 
ATOM   375  C  C   . ILE A 1 56  ? -32.74557 -7.34321  18.94214 1.000 43.44911  ? 52  ILE A C   1 
ATOM   376  O  O   . ILE A 1 56  ? -32.37974 -7.50137  20.11270 1.000 45.83787  ? 52  ILE A O   1 
ATOM   377  C  CB  . ILE A 1 56  ? -32.41349 -5.10976  17.79293 1.000 35.70368  ? 52  ILE A CB  1 
ATOM   378  C  CG1 . ILE A 1 56  ? -31.53969 -4.34517  16.79065 1.000 36.35765  ? 52  ILE A CG1 1 
ATOM   379  C  CG2 . ILE A 1 56  ? -32.50270 -4.41052  19.14740 1.000 40.34523  ? 52  ILE A CG2 1 
ATOM   380  C  CD1 . ILE A 1 56  ? -31.13600 -2.95483  17.23467 1.000 34.22042  ? 52  ILE A CD1 1 
ATOM   381  N  N   . ASN A 1 57  ? -33.88188 -7.87023  18.47873 1.000 45.41783  ? 53  ASN A N   1 
ATOM   382  C  CA  . ASN A 1 57  ? -34.82217 -8.53518  19.37534 1.000 49.27473  ? 53  ASN A CA  1 
ATOM   383  C  C   . ASN A 1 57  ? -34.24362 -9.81562  19.96992 1.000 45.06936  ? 53  ASN A C   1 
ATOM   384  O  O   . ASN A 1 57  ? -34.61848 -10.20100 21.08414 1.000 46.28332  ? 53  ASN A O   1 
ATOM   385  C  CB  . ASN A 1 57  ? -36.12559 -8.82627  18.62860 1.000 44.71146  ? 53  ASN A CB  1 
ATOM   386  C  CG  . ASN A 1 57  ? -36.88198 -10.00619 19.20588 1.000 58.86045  ? 53  ASN A CG  1 
ATOM   387  O  OD1 . ASN A 1 57  ? -37.37878 -9.94861  20.33112 1.000 56.08791  ? 53  ASN A OD1 1 
ATOM   388  N  ND2 . ASN A 1 57  ? -36.97521 -11.08459 18.43588 1.000 59.97703  ? 53  ASN A ND2 1 
ATOM   389  N  N   A GLU A 1 58  ? -33.32889 -10.47828 19.25670 0.465 46.18954  ? 54  GLU A N   1 
ATOM   390  N  N   B GLU A 1 58  ? -33.33377 -10.48016 19.25027 0.535 46.18034  ? 54  GLU A N   1 
ATOM   391  C  CA  A GLU A 1 58  ? -32.76545 -11.72780 19.75857 0.465 48.84668  ? 54  GLU A CA  1 
ATOM   392  C  CA  B GLU A 1 58  ? -32.75139 -11.72382 19.74730 0.535 48.85899  ? 54  GLU A CA  1 
ATOM   393  C  C   A GLU A 1 58  ? -31.94381 -11.51444 21.02324 0.465 48.01202  ? 54  GLU A C   1 
ATOM   394  C  C   B GLU A 1 58  ? -31.95580 -11.50872 21.02677 0.535 48.01652  ? 54  GLU A C   1 
ATOM   395  O  O   A GLU A 1 58  ? -31.80922 -12.43549 21.83660 0.465 47.74551  ? 54  GLU A O   1 
ATOM   396  O  O   B GLU A 1 58  ? -31.85051 -12.42287 21.85222 0.535 47.74334  ? 54  GLU A O   1 
ATOM   397  C  CB  A GLU A 1 58  ? -31.90711 -12.39051 18.67912 0.465 47.78840  ? 54  GLU A CB  1 
ATOM   398  C  CB  B GLU A 1 58  ? -31.85390 -12.35453 18.68001 0.535 47.77632  ? 54  GLU A CB  1 
ATOM   399  C  CG  A GLU A 1 58  ? -32.69421 -13.12998 17.60178 0.465 46.10150  ? 54  GLU A CG  1 
ATOM   400  C  CG  B GLU A 1 58  ? -32.59559 -12.89244 17.47049 0.535 45.82566  ? 54  GLU A CG  1 
ATOM   401  C  CD  A GLU A 1 58  ? -33.47452 -14.32097 18.13670 0.465 48.22823  ? 54  GLU A CD  1 
ATOM   402  C  CD  B GLU A 1 58  ? -31.71358 -12.98329 16.24048 0.535 46.07773  ? 54  GLU A CD  1 
ATOM   403  O  OE1 A GLU A 1 58  ? -33.13363 -14.82900 19.22641 0.465 47.26473  ? 54  GLU A OE1 1 
ATOM   404  O  OE1 B GLU A 1 58  ? -30.51677 -13.30942 16.38743 0.535 46.62031  ? 54  GLU A OE1 1 
ATOM   405  O  OE2 A GLU A 1 58  ? -34.43304 -14.75231 17.46140 0.465 45.50337  ? 54  GLU A OE2 1 
ATOM   406  O  OE2 B GLU A 1 58  ? -32.21468 -12.71965 15.12771 0.535 50.16901  ? 54  GLU A OE2 1 
ATOM   407  N  N   . VAL A 1 59  ? -31.39023 -10.31614 21.21111 1.000 47.98998  ? 55  VAL A N   1 
ATOM   408  C  CA  . VAL A 1 59  ? -30.52285 -10.02669 22.34376 1.000 43.61273  ? 55  VAL A CA  1 
ATOM   409  C  C   . VAL A 1 59  ? -31.02199 -8.86630  23.18877 1.000 45.41801  ? 55  VAL A C   1 
ATOM   410  O  O   . VAL A 1 59  ? -30.38844 -8.53320  24.19515 1.000 43.75728  ? 55  VAL A O   1 
ATOM   411  C  CB  . VAL A 1 59  ? -29.07613 -9.76245  21.87867 1.000 42.09799  ? 55  VAL A CB  1 
ATOM   412  C  CG1 . VAL A 1 59  ? -28.46410 -11.03560 21.32072 1.000 43.76598  ? 55  VAL A CG1 1 
ATOM   413  C  CG2 . VAL A 1 59  ? -29.05040 -8.65377  20.83901 1.000 46.97363  ? 55  VAL A CG2 1 
ATOM   414  N  N   . ASP A 1 60  ? -32.13565 -8.24095  22.81723 1.000 46.46099  ? 56  ASP A N   1 
ATOM   415  C  CA  . ASP A 1 60  ? -32.65092 -7.08469  23.54752 1.000 43.85532  ? 56  ASP A CA  1 
ATOM   416  C  C   . ASP A 1 60  ? -33.34947 -7.58739  24.80494 1.000 46.11032  ? 56  ASP A C   1 
ATOM   417  O  O   . ASP A 1 60  ? -34.56056 -7.80991  24.82726 1.000 49.95751  ? 56  ASP A O   1 
ATOM   418  C  CB  . ASP A 1 60  ? -33.58649 -6.26862  22.66666 1.000 41.25119  ? 56  ASP A CB  1 
ATOM   419  C  CG  . ASP A 1 60  ? -34.02079 -4.98235  23.32172 1.000 42.32485  ? 56  ASP A CG  1 
ATOM   420  O  OD1 . ASP A 1 60  ? -33.21193 -4.40323  24.07486 1.000 42.64214  ? 56  ASP A OD1 1 
ATOM   421  O  OD2 . ASP A 1 60  ? -35.15901 -4.54175  23.06686 1.000 49.18580  ? 56  ASP A OD2 1 
ATOM   422  N  N   . ALA A 1 61  ? -32.56904 -7.76272  25.87413 1.000 49.52503  ? 57  ALA A N   1 
ATOM   423  C  CA  . ALA A 1 61  ? -33.10806 -8.35719  27.09273 1.000 54.45806  ? 57  ALA A CA  1 
ATOM   424  C  C   . ALA A 1 61  ? -34.00377 -7.38155  27.84686 1.000 55.01487  ? 57  ALA A C   1 
ATOM   425  O  O   . ALA A 1 61  ? -35.02188 -7.78664  28.41858 1.000 57.17466  ? 57  ALA A O   1 
ATOM   426  C  CB  . ALA A 1 61  ? -31.96779 -8.84411  27.98662 1.000 54.93990  ? 57  ALA A CB  1 
ATOM   427  N  N   . ASP A 1 62  ? -33.64525 -6.09795  27.86878 1.000 53.03832  ? 58  ASP A N   1 
ATOM   428  C  CA  . ASP A 1 62  ? -34.41691 -5.11268  28.61480 1.000 53.37466  ? 58  ASP A CA  1 
ATOM   429  C  C   . ASP A 1 62  ? -35.58397 -4.54381  27.82031 1.000 44.55548  ? 58  ASP A C   1 
ATOM   430  O  O   . ASP A 1 62  ? -36.42103 -3.84122  28.39789 1.000 45.20146  ? 58  ASP A O   1 
ATOM   431  C  CB  . ASP A 1 62  ? -33.50973 -3.97096  29.08038 1.000 54.86520  ? 58  ASP A CB  1 
ATOM   432  C  CG  . ASP A 1 62  ? -32.73279 -3.34534  27.94391 1.000 56.16679  ? 58  ASP A CG  1 
ATOM   433  O  OD1 . ASP A 1 62  ? -32.82804 -3.85374  26.80845 1.000 47.26201  ? 58  ASP A OD1 1 
ATOM   434  O  OD2 . ASP A 1 62  ? -32.01332 -2.35497  28.18949 1.000 54.72752  ? 58  ASP A OD2 1 
ATOM   435  N  N   . GLY A 1 63  ? -35.65247 -4.81656  26.51957 1.000 50.97973  ? 59  GLY A N   1 
ATOM   436  C  CA  . GLY A 1 63  ? -36.80085 -4.41694  25.73133 1.000 52.31830  ? 59  GLY A CA  1 
ATOM   437  C  C   . GLY A 1 63  ? -36.86453 -2.95314  25.36149 1.000 54.54081  ? 59  GLY A C   1 
ATOM   438  O  O   . GLY A 1 63  ? -37.96369 -2.41834  25.18382 1.000 56.78406  ? 59  GLY A O   1 
ATOM   439  N  N   . ASN A 1 64  ? -35.71940 -2.28350  25.23177 1.000 49.11522  ? 60  ASN A N   1 
ATOM   440  C  CA  . ASN A 1 64  ? -35.68765 -0.87071  24.87686 1.000 44.71030  ? 60  ASN A CA  1 
ATOM   441  C  C   . ASN A 1 64  ? -35.45405 -0.64043  23.38796 1.000 44.31151  ? 60  ASN A C   1 
ATOM   442  O  O   . ASN A 1 64  ? -35.20075 0.49763   22.97991 1.000 48.27571  ? 60  ASN A O   1 
ATOM   443  C  CB  . ASN A 1 64  ? -34.62082 -0.13740  25.69608 1.000 42.42811  ? 60  ASN A CB  1 
ATOM   444  C  CG  . ASN A 1 64  ? -33.20786 -0.50116  25.28172 1.000 38.54733  ? 60  ASN A CG  1 
ATOM   445  O  OD1 . ASN A 1 64  ? -32.96927 -1.56024  24.70261 1.000 44.16540  ? 60  ASN A OD1 1 
ATOM   446  N  ND2 . ASN A 1 64  ? -32.26148 0.38240   25.57552 1.000 42.20841  ? 60  ASN A ND2 1 
ATOM   447  N  N   . GLY A 1 65  ? -35.52464 -1.69192  22.57103 1.000 47.30476  ? 61  GLY A N   1 
ATOM   448  C  CA  . GLY A 1 65  ? -35.39800 -1.56404  21.13467 1.000 43.26580  ? 61  GLY A CA  1 
ATOM   449  C  C   . GLY A 1 65  ? -33.99460 -1.34685  20.61438 1.000 44.09478  ? 61  GLY A C   1 
ATOM   450  O  O   . GLY A 1 65  ? -33.79456 -1.38795  19.39335 1.000 37.25257  ? 61  GLY A O   1 
ATOM   451  N  N   . THR A 1 66  ? -33.01848 -1.11385  21.48577 1.000 38.99708  ? 62  THR A N   1 
ATOM   452  C  CA  . THR A 1 66  ? -31.63414 -0.90903  21.08925 1.000 34.19021  ? 62  THR A CA  1 
ATOM   453  C  C   . THR A 1 66  ? -30.74897 -1.96334  21.74309 1.000 39.52206  ? 62  THR A C   1 
ATOM   454  O  O   . THR A 1 66  ? -31.19017 -2.74422  22.59006 1.000 33.63837  ? 62  THR A O   1 
ATOM   455  C  CB  . THR A 1 66  ? -31.15129 0.49955   21.46360 1.000 38.26136  ? 62  THR A CB  1 
ATOM   456  O  OG1 . THR A 1 66  ? -31.37763 0.73085   22.85976 1.000 40.93061  ? 62  THR A OG1 1 
ATOM   457  C  CG2 . THR A 1 66  ? -31.89519 1.55081   20.65360 1.000 31.24182  ? 62  THR A CG2 1 
ATOM   458  N  N   . ILE A 1 67  ? -29.48245 -1.97719  21.33587 1.000 31.71120  ? 63  ILE A N   1 
ATOM   459  C  CA  . ILE A 1 67  ? -28.49392 -2.92597  21.83654 1.000 37.25571  ? 63  ILE A CA  1 
ATOM   460  C  C   . ILE A 1 67  ? -27.40226 -2.14093  22.54717 1.000 38.55711  ? 63  ILE A C   1 
ATOM   461  O  O   . ILE A 1 67  ? -26.75968 -1.27412  21.94144 1.000 34.07410  ? 63  ILE A O   1 
ATOM   462  C  CB  . ILE A 1 67  ? -27.89618 -3.78231  20.70897 1.000 37.23668  ? 63  ILE A CB  1 
ATOM   463  C  CG1 . ILE A 1 67  ? -28.99897 -4.53012  19.95850 1.000 39.58605  ? 63  ILE A CG1 1 
ATOM   464  C  CG2 . ILE A 1 67  ? -26.86522 -4.75418  21.26819 1.000 39.75588  ? 63  ILE A CG2 1 
ATOM   465  C  CD1 . ILE A 1 67  ? -28.47952 -5.52674  18.94365 1.000 41.25328  ? 63  ILE A CD1 1 
ATOM   466  N  N   . ASP A 1 68  ? -27.19038 -2.44343  23.82335 1.000 36.66176  ? 64  ASP A N   1 
ATOM   467  C  CA  . ASP A 1 68  ? -26.10753 -1.84941  24.58628 1.000 37.59275  ? 64  ASP A CA  1 
ATOM   468  C  C   . ASP A 1 68  ? -24.94579 -2.83684  24.69323 1.000 42.91153  ? 64  ASP A C   1 
ATOM   469  O  O   . ASP A 1 68  ? -24.97235 -3.93292  24.12641 1.000 39.86738  ? 64  ASP A O   1 
ATOM   470  C  CB  . ASP A 1 68  ? -26.60782 -1.38680  25.95937 1.000 39.59600  ? 64  ASP A CB  1 
ATOM   471  C  CG  . ASP A 1 68  ? -27.24906 -2.50229  26.76702 1.000 43.75071  ? 64  ASP A CG  1 
ATOM   472  O  OD1 . ASP A 1 68  ? -27.11381 -3.68479  26.39165 1.000 44.37850  ? 64  ASP A OD1 1 
ATOM   473  O  OD2 . ASP A 1 68  ? -27.89898 -2.19014  27.78707 1.000 48.72570  ? 64  ASP A OD2 1 
ATOM   474  N  N   . PHE A 1 69  ? -23.91179 -2.43401  25.43191 1.000 43.68318  ? 65  PHE A N   1 
ATOM   475  C  CA  . PHE A 1 69  ? -22.69448 -3.23876  25.50054 1.000 36.15632  ? 65  PHE A CA  1 
ATOM   476  C  C   . PHE A 1 69  ? -22.91473 -4.63957  26.06591 1.000 38.88326  ? 65  PHE A C   1 
ATOM   477  O  O   . PHE A 1 69  ? -22.36434 -5.59408  25.48826 1.000 37.68003  ? 65  PHE A O   1 
ATOM   478  C  CB  . PHE A 1 69  ? -21.62409 -2.48019  26.29776 1.000 43.99949  ? 65  PHE A CB  1 
ATOM   479  C  CG  . PHE A 1 69  ? -20.22758 -2.99136  26.07972 1.000 33.00981  ? 65  PHE A CG  1 
ATOM   480  C  CD1 . PHE A 1 69  ? -19.47606 -2.55236  25.00239 1.000 40.07302  ? 65  PHE A CD1 1 
ATOM   481  C  CD2 . PHE A 1 69  ? -19.66003 -3.89729  26.95940 1.000 41.70677  ? 65  PHE A CD2 1 
ATOM   482  C  CE1 . PHE A 1 69  ? -18.19114 -3.01750  24.79867 1.000 42.00103  ? 65  PHE A CE1 1 
ATOM   483  C  CE2 . PHE A 1 69  ? -18.37291 -4.36102  26.76214 1.000 43.48940  ? 65  PHE A CE2 1 
ATOM   484  C  CZ  . PHE A 1 69  ? -17.63977 -3.92344  25.67969 1.000 37.51089  ? 65  PHE A CZ  1 
ATOM   485  N  N   . PRO A 1 70  ? -23.66655 -4.84702  27.15722 1.000 39.24313  ? 66  PRO A N   1 
ATOM   486  C  CA  . PRO A 1 70  ? -23.91750 -6.23273  27.59462 1.000 41.77573  ? 66  PRO A CA  1 
ATOM   487  C  C   . PRO A 1 70  ? -24.64050 -7.06639  26.55336 1.000 39.75288  ? 66  PRO A C   1 
ATOM   488  O  O   . PRO A 1 70  ? -24.27636 -8.22713  26.32757 1.000 36.72040  ? 66  PRO A O   1 
ATOM   489  C  CB  . PRO A 1 70  ? -24.76689 -6.05124  28.85971 1.000 38.56284  ? 66  PRO A CB  1 
ATOM   490  C  CG  . PRO A 1 70  ? -24.40234 -4.71086  29.36322 1.000 40.18510  ? 66  PRO A CG  1 
ATOM   491  C  CD  . PRO A 1 70  ? -24.15930 -3.87120  28.14714 1.000 36.38401  ? 66  PRO A CD  1 
ATOM   492  N  N   . GLU A 1 71  ? -25.66105 -6.49866  25.90692 1.000 35.64141  ? 67  GLU A N   1 
ATOM   493  C  CA  . GLU A 1 71  ? -26.40679 -7.23770  24.89395 1.000 34.64152  ? 67  GLU A CA  1 
ATOM   494  C  C   . GLU A 1 71  ? -25.58378 -7.44296  23.62980 1.000 35.64750  ? 67  GLU A C   1 
ATOM   495  O  O   . GLU A 1 71  ? -25.80029 -8.41866  22.90192 1.000 41.98476  ? 67  GLU A O   1 
ATOM   496  C  CB  . GLU A 1 71  ? -27.70833 -6.50581  24.57651 1.000 42.79135  ? 67  GLU A CB  1 
ATOM   497  C  CG  . GLU A 1 71  ? -28.62378 -6.39427  25.77808 1.000 36.02887  ? 67  GLU A CG  1 
ATOM   498  C  CD  . GLU A 1 71  ? -29.72673 -5.38353  25.57802 1.000 44.53666  ? 67  GLU A CD  1 
ATOM   499  O  OE1 . GLU A 1 71  ? -29.84557 -4.84054  24.45929 1.000 45.32826  ? 67  GLU A OE1 1 
ATOM   500  O  OE2 . GLU A 1 71  ? -30.46249 -5.12046  26.54972 1.000 47.11371  ? 67  GLU A OE2 1 
ATOM   501  N  N   . PHE A 1 72  ? -24.64479 -6.53645  23.35108 1.000 41.86971  ? 68  PHE A N   1 
ATOM   502  C  CA  . PHE A 1 72  ? -23.72600 -6.73729  22.23642 1.000 35.81003  ? 68  PHE A CA  1 
ATOM   503  C  C   . PHE A 1 72  ? -22.79876 -7.91564  22.50455 1.000 45.49377  ? 68  PHE A C   1 
ATOM   504  O  O   . PHE A 1 72  ? -22.52931 -8.72266  21.60707 1.000 44.90733  ? 68  PHE A O   1 
ATOM   505  C  CB  . PHE A 1 72  ? -22.92952 -5.45437  21.99035 1.000 37.74604  ? 68  PHE A CB  1 
ATOM   506  C  CG  . PHE A 1 72  ? -21.81400 -5.60727  20.99675 1.000 41.76816  ? 68  PHE A CG  1 
ATOM   507  C  CD1 . PHE A 1 72  ? -20.53679 -5.95282  21.41157 1.000 43.39809  ? 68  PHE A CD1 1 
ATOM   508  C  CD2 . PHE A 1 72  ? -22.04177 -5.40325  19.64682 1.000 46.84267  ? 68  PHE A CD2 1 
ATOM   509  C  CE1 . PHE A 1 72  ? -19.51227 -6.09526  20.49916 1.000 49.27911  ? 68  PHE A CE1 1 
ATOM   510  C  CE2 . PHE A 1 72  ? -21.02054 -5.54335  18.72933 1.000 44.53271  ? 68  PHE A CE2 1 
ATOM   511  C  CZ  . PHE A 1 72  ? -19.75417 -5.89008  19.15597 1.000 45.35032  ? 68  PHE A CZ  1 
ATOM   512  N  N   . LEU A 1 73  ? -22.30488 -8.02858  23.73899 1.000 45.90264  ? 69  LEU A N   1 
ATOM   513  C  CA  . LEU A 1 73  ? -21.45151 -9.15087  24.10974 1.000 42.32456  ? 69  LEU A CA  1 
ATOM   514  C  C   . LEU A 1 73  ? -22.21146 -10.47125 24.07675 1.000 48.15749  ? 69  LEU A C   1 
ATOM   515  O  O   . LEU A 1 73  ? -21.61158 -11.52293 23.82905 1.000 43.26676  ? 69  LEU A O   1 
ATOM   516  C  CB  . LEU A 1 73  ? -20.85744 -8.90784  25.49602 1.000 36.54543  ? 69  LEU A CB  1 
ATOM   517  C  CG  . LEU A 1 73  ? -19.77228 -7.83379  25.59194 1.000 44.02066  ? 69  LEU A CG  1 
ATOM   518  C  CD1 . LEU A 1 73  ? -19.43544 -7.56224  27.04452 1.000 43.38135  ? 69  LEU A CD1 1 
ATOM   519  C  CD2 . LEU A 1 73  ? -18.52744 -8.25815  24.83032 1.000 38.01917  ? 69  LEU A CD2 1 
ATOM   520  N  N   . THR A 1 74  ? -23.52236 -10.43924 24.33022 1.000 40.38936  ? 70  THR A N   1 
ATOM   521  C  CA  . THR A 1 74  ? -24.33266 -11.64814 24.21657 1.000 41.17481  ? 70  THR A CA  1 
ATOM   522  C  C   . THR A 1 74  ? -24.52872 -12.04451 22.75772 1.000 50.03312  ? 70  THR A C   1 
ATOM   523  O  O   . THR A 1 74  ? -24.49750 -13.23420 22.42078 1.000 49.46110  ? 70  THR A O   1 
ATOM   524  C  CB  . THR A 1 74  ? -25.68334 -11.43666 24.90197 1.000 43.71368  ? 70  THR A CB  1 
ATOM   525  O  OG1 . THR A 1 74  ? -25.47585 -11.13144 26.28713 1.000 44.32904  ? 70  THR A OG1 1 
ATOM   526  C  CG2 . THR A 1 74  ? -26.54845 -12.68120 24.78464 1.000 40.63644  ? 70  THR A CG2 1 
HETATM 527  N  N   . MSE A 1 75  ? -24.73394 -11.06461 21.88289 1.000 50.66332  ? 71  MSE A N   1 
HETATM 528  C  CA  . MSE A 1 75  ? -24.88209 -11.31381 20.45379 1.000 57.41836  ? 71  MSE A CA  1 
HETATM 529  C  C   . MSE A 1 75  ? -23.60553 -11.91740 19.87564 1.000 60.26981  ? 71  MSE A C   1 
HETATM 530  O  O   . MSE A 1 75  ? -23.65572 -12.83132 19.05239 1.000 57.61365  ? 71  MSE A O   1 
HETATM 531  C  CB  . MSE A 1 75  ? -25.23316 -10.01563 19.72137 1.000 56.94885  ? 71  MSE A CB  1 
HETATM 532  C  CG  . MSE A 1 75  ? -25.44261 -10.16535 18.22178 1.000 55.90545  ? 71  MSE A CG  1 
HETATM 533  SE SE  . MSE A 1 75  ? -26.45565 -11.75916 17.73705 1.000 102.99241 ? 71  MSE A SE  1 
HETATM 534  C  CE  . MSE A 1 75  ? -27.77374 -10.93109 16.56173 1.000 62.47146  ? 71  MSE A CE  1 
HETATM 535  N  N   . MSE A 1 76  ? -22.46366 -11.40110 20.32135 1.000 57.79147  ? 72  MSE A N   1 
HETATM 536  C  CA  . MSE A 1 76  ? -21.16216 -11.87580 19.86258 1.000 61.32409  ? 72  MSE A CA  1 
HETATM 537  C  C   . MSE A 1 76  ? -20.93790 -13.33767 20.23270 1.000 60.26043  ? 72  MSE A C   1 
HETATM 538  O  O   . MSE A 1 76  ? -20.47236 -14.13030 19.41271 1.000 56.85336  ? 72  MSE A O   1 
HETATM 539  C  CB  . MSE A 1 76  ? -20.04221 -11.01482 20.45083 1.000 62.20398  ? 72  MSE A CB  1 
HETATM 540  C  CG  . MSE A 1 76  ? -19.91893 -9.63530  19.82658 1.000 63.04492  ? 72  MSE A CG  1 
HETATM 541  SE SE  . MSE A 1 76  ? -19.28505 -9.68875  17.98719 1.000 116.16079 ? 72  MSE A SE  1 
HETATM 542  C  CE  . MSE A 1 76  ? -20.96544 -9.31293  17.07159 1.000 75.81612  ? 72  MSE A CE  1 
ATOM   543  N  N   . ALA A 1 77  ? -21.27512 -13.68537 21.47821 1.000 52.80835  ? 73  ALA A N   1 
ATOM   544  C  CA  . ALA A 1 77  ? -21.08203 -15.05412 21.94605 1.000 60.70423  ? 73  ALA A CA  1 
ATOM   545  C  C   . ALA A 1 77  ? -21.90994 -16.04785 21.14217 1.000 60.68358  ? 73  ALA A C   1 
ATOM   546  O  O   . ALA A 1 77  ? -21.52677 -17.21684 21.01795 1.000 64.23268  ? 73  ALA A O   1 
ATOM   547  C  CB  . ALA A 1 77  ? -21.42700 -15.15432 23.43195 1.000 55.18675  ? 73  ALA A CB  1 
ATOM   548  N  N   . ARG A 1 78  ? -23.04118 -15.60648 20.58867 1.000 53.54930  ? 74  ARG A N   1 
ATOM   549  C  CA  . ARG A 1 78  ? -23.86640 -16.49702 19.77916 1.000 60.09277  ? 74  ARG A CA  1 
ATOM   550  C  C   . ARG A 1 78  ? -23.23988 -16.73193 18.41030 1.000 59.16124  ? 74  ARG A C   1 
ATOM   551  O  O   . ARG A 1 78  ? -23.07669 -17.87952 17.97945 1.000 64.15650  ? 74  ARG A O   1 
ATOM   552  C  CB  . ARG A 1 78  ? -25.27428 -15.91864 19.63033 1.000 61.80663  ? 74  ARG A CB  1 
ATOM   553  C  CG  . ARG A 1 78  ? -26.01277 -15.72202 20.94099 1.000 57.94292  ? 74  ARG A CG  1 
ATOM   554  C  CD  . ARG A 1 78  ? -27.28980 -16.54338 20.99030 1.000 50.07388  ? 74  ARG A CD  1 
ATOM   555  N  NE  . ARG A 1 78  ? -28.02698 -16.31594 22.22744 1.000 57.70313  ? 74  ARG A NE  1 
ATOM   556  C  CZ  . ARG A 1 78  ? -28.95381 -15.38034 22.38323 1.000 48.55986  ? 74  ARG A CZ  1 
ATOM   557  N  NH1 . ARG A 1 78  ? -29.28726 -14.56633 21.39472 1.000 50.66830  ? 74  ARG A NH1 1 
ATOM   558  N  NH2 . ARG A 1 78  ? -29.55906 -15.25589 23.56089 1.000 45.44786  ? 74  ARG A NH2 1 
ATOM   559  N  N   . LYS A 1 79  ? -22.88227 -15.65130 17.71113 1.000 57.58540  ? 75  LYS A N   1 
ATOM   560  C  CA  . LYS A 1 79  ? -22.34997 -15.78511 16.35868 1.000 62.80876  ? 75  LYS A CA  1 
ATOM   561  C  C   . LYS A 1 79  ? -21.01472 -16.51905 16.35873 1.000 61.26354  ? 75  LYS A C   1 
ATOM   562  O  O   . LYS A 1 79  ? -20.71684 -17.27860 15.42933 1.000 68.32533  ? 75  LYS A O   1 
ATOM   563  C  CB  . LYS A 1 79  ? -22.21614 -14.40641 15.71127 1.000 60.56110  ? 75  LYS A CB  1 
ATOM   564  C  CG  . LYS A 1 79  ? -23.43083 -13.51319 15.92335 1.000 63.95862  ? 75  LYS A CG  1 
ATOM   565  C  CD  . LYS A 1 79  ? -23.30074 -12.19357 15.18158 1.000 60.37920  ? 75  LYS A CD  1 
ATOM   566  C  CE  . LYS A 1 79  ? -23.41441 -12.39153 13.67844 1.000 73.80248  ? 75  LYS A CE  1 
ATOM   567  N  NZ  . LYS A 1 79  ? -24.78287 -12.82343 13.27302 1.000 67.97123  ? 75  LYS A NZ  1 
HETATM 568  N  N   . MSE A 1 80  ? -20.19944 -16.30829 17.38766 1.000 63.89053  ? 76  MSE A N   1 
HETATM 569  C  CA  . MSE A 1 80  ? -18.97267 -17.07989 17.54650 1.000 64.75192  ? 76  MSE A CA  1 
HETATM 570  C  C   . MSE A 1 80  ? -19.26593 -18.43007 18.18913 1.000 62.26666  ? 76  MSE A C   1 
HETATM 571  O  O   . MSE A 1 80  ? -19.24782 -19.46419 17.52095 1.000 62.12269  ? 76  MSE A O   1 
HETATM 572  C  CB  . MSE A 1 80  ? -17.94364 -16.31523 18.38440 1.000 61.83340  ? 76  MSE A CB  1 
HETATM 573  C  CG  . MSE A 1 80  ? -17.35267 -15.09681 17.70049 1.000 70.32124  ? 76  MSE A CG  1 
HETATM 574  SE SE  . MSE A 1 80  ? -15.79088 -14.41814 18.65083 1.000 111.82097 ? 76  MSE A SE  1 
HETATM 575  C  CE  . MSE A 1 80  ? -14.56429 -15.89696 18.30844 1.000 63.40473  ? 76  MSE A CE  1 
ATOM   576  N  N   . THR A 1 83  ? -23.64168 -20.61753 16.51927 1.000 63.79685  ? 79  THR A N   1 
ATOM   577  C  CA  . THR A 1 83  ? -24.30875 -21.09921 15.31681 1.000 68.69731  ? 79  THR A CA  1 
ATOM   578  C  C   . THR A 1 83  ? -23.32393 -21.86379 14.43914 1.000 71.98761  ? 79  THR A C   1 
ATOM   579  O  O   . THR A 1 83  ? -22.11066 -21.77121 14.62854 1.000 72.72359  ? 79  THR A O   1 
ATOM   580  C  CB  . THR A 1 83  ? -24.92343 -19.93896 14.50441 1.000 68.74740  ? 79  THR A CB  1 
ATOM   581  O  OG1 . THR A 1 83  ? -25.33610 -18.89540 15.39446 1.000 59.26023  ? 79  THR A OG1 1 
ATOM   582  C  CG2 . THR A 1 83  ? -26.13539 -20.41888 13.71844 1.000 64.93338  ? 79  THR A CG2 1 
ATOM   583  N  N   . ASP A 1 84  ? -23.84987 -22.62581 13.48403 1.000 68.65737  ? 80  ASP A N   1 
ATOM   584  C  CA  . ASP A 1 84  ? -23.04738 -23.33259 12.49453 1.000 69.46575  ? 80  ASP A CA  1 
ATOM   585  C  C   . ASP A 1 84  ? -23.46606 -22.94016 11.08341 1.000 69.19949  ? 80  ASP A C   1 
ATOM   586  O  O   . ASP A 1 84  ? -23.57901 -23.78047 10.18842 1.000 69.76573  ? 80  ASP A O   1 
ATOM   587  C  CB  . ASP A 1 84  ? -23.14207 -24.84371 12.68765 1.000 69.32425  ? 80  ASP A CB  1 
ATOM   588  C  CG  . ASP A 1 84  ? -21.78284 -25.51373 12.68924 1.000 65.98346  ? 80  ASP A CG  1 
ATOM   589  O  OD1 . ASP A 1 84  ? -20.77438 -24.80841 12.90460 1.000 67.89093  ? 80  ASP A OD1 1 
ATOM   590  O  OD2 . ASP A 1 84  ? -21.71943 -26.74152 12.47194 1.000 66.00266  ? 80  ASP A OD2 1 
ATOM   591  N  N   . SER A 1 85  ? -23.70682 -21.64714 10.87449 1.000 64.20767  ? 81  SER A N   1 
ATOM   592  C  CA  . SER A 1 85  ? -24.04909 -21.11574 9.55627  1.000 57.17207  ? 81  SER A CA  1 
ATOM   593  C  C   . SER A 1 85  ? -22.74963 -20.73482 8.85872  1.000 55.96415  ? 81  SER A C   1 
ATOM   594  O  O   . SER A 1 85  ? -22.27797 -19.59966 8.94572  1.000 52.68515  ? 81  SER A O   1 
ATOM   595  C  CB  . SER A 1 85  ? -24.99804 -19.93031 9.67994  1.000 60.52931  ? 81  SER A CB  1 
ATOM   596  O  OG  . SER A 1 85  ? -25.17719 -19.28532 8.43156  1.000 51.17271  ? 81  SER A OG  1 
ATOM   597  N  N   . GLU A 1 86  ? -22.15928 -21.70896 8.16123  1.000 51.91566  ? 82  GLU A N   1 
ATOM   598  C  CA  . GLU A 1 86  ? -20.90664 -21.46892 7.45273  1.000 48.51234  ? 82  GLU A CA  1 
ATOM   599  C  C   . GLU A 1 86  ? -21.07112 -20.42192 6.35903  1.000 42.33525  ? 82  GLU A C   1 
ATOM   600  O  O   . GLU A 1 86  ? -20.12879 -19.67546 6.06926  1.000 31.68012  ? 82  GLU A O   1 
ATOM   601  C  CB  . GLU A 1 86  ? -20.38542 -22.78188 6.86209  1.000 53.67201  ? 82  GLU A CB  1 
ATOM   602  C  CG  . GLU A 1 86  ? -19.05823 -22.66989 6.12464  1.000 53.18602  ? 82  GLU A CG  1 
ATOM   603  C  CD  . GLU A 1 86  ? -17.86291 -22.66253 7.05993  1.000 64.97312  ? 82  GLU A CD  1 
ATOM   604  O  OE1 . GLU A 1 86  ? -18.06218 -22.66665 8.29324  1.000 63.76259  ? 82  GLU A OE1 1 
ATOM   605  O  OE2 . GLU A 1 86  ? -16.71918 -22.65376 6.55939  1.000 52.65012  ? 82  GLU A OE2 1 
ATOM   606  N  N   . GLU A 1 87  ? -22.25754 -20.34905 5.74818  1.000 35.84968  ? 83  GLU A N   1 
ATOM   607  C  CA  . GLU A 1 87  ? -22.48464 -19.39498 4.66707  1.000 42.09585  ? 83  GLU A CA  1 
ATOM   608  C  C   . GLU A 1 87  ? -22.27233 -17.96301 5.13960  1.000 35.04913  ? 83  GLU A C   1 
ATOM   609  O  O   . GLU A 1 87  ? -21.72272 -17.13472 4.40408  1.000 36.18868  ? 83  GLU A O   1 
ATOM   610  C  CB  . GLU A 1 87  ? -23.89495 -19.57225 4.09913  1.000 38.37588  ? 83  GLU A CB  1 
ATOM   611  C  CG  . GLU A 1 87  ? -24.34344 -18.45701 3.15761  1.000 28.60803  ? 83  GLU A CG  1 
ATOM   612  C  CD  . GLU A 1 87  ? -23.55091 -18.40843 1.86141  1.000 34.48844  ? 83  GLU A CD  1 
ATOM   613  O  OE1 . GLU A 1 87  ? -22.80389 -19.36655 1.56806  1.000 30.10580  ? 83  GLU A OE1 1 
ATOM   614  O  OE2 . GLU A 1 87  ? -23.67279 -17.40181 1.13208  1.000 34.18002  ? 83  GLU A OE2 1 
ATOM   615  N  N   . GLU A 1 88  ? -22.69801 -17.65554 6.36801  1.000 34.19864  ? 84  GLU A N   1 
ATOM   616  C  CA  . GLU A 1 88  ? -22.47399 -16.32479 6.92418  1.000 40.70518  ? 84  GLU A CA  1 
ATOM   617  C  C   . GLU A 1 88  ? -20.98865 -15.98916 6.96296  1.000 37.42139  ? 84  GLU A C   1 
ATOM   618  O  O   . GLU A 1 88  ? -20.59713 -14.83604 6.74652  1.000 31.32367  ? 84  GLU A O   1 
ATOM   619  C  CB  . GLU A 1 88  ? -23.08761 -16.23923 8.32314  1.000 45.48265  ? 84  GLU A CB  1 
ATOM   620  C  CG  . GLU A 1 88  ? -22.22737 -15.52295 9.35532  1.000 45.75804  ? 84  GLU A CG  1 
ATOM   621  C  CD  . GLU A 1 88  ? -22.84706 -15.53636 10.73763 1.000 59.63248  ? 84  GLU A CD  1 
ATOM   622  O  OE1 . GLU A 1 88  ? -23.97037 -15.01091 10.89270 1.000 54.47820  ? 84  GLU A OE1 1 
ATOM   623  O  OE2 . GLU A 1 88  ? -22.21346 -16.07774 11.66761 1.000 53.45582  ? 84  GLU A OE2 1 
ATOM   624  N  N   . ILE A 1 89  ? -20.14551 -16.98957 7.21857  1.000 36.17313  ? 85  ILE A N   1 
ATOM   625  C  CA  . ILE A 1 89  ? -18.70649 -16.75895 7.26836  1.000 34.80296  ? 85  ILE A CA  1 
ATOM   626  C  C   . ILE A 1 89  ? -18.12977 -16.63521 5.86428  1.000 23.60420  ? 85  ILE A C   1 
ATOM   627  O  O   . ILE A 1 89  ? -17.29411 -15.76347 5.60248  1.000 23.53628  ? 85  ILE A O   1 
ATOM   628  C  CB  . ILE A 1 89  ? -18.02106 -17.87954 8.06995  1.000 38.21159  ? 85  ILE A CB  1 
ATOM   629  C  CG1 . ILE A 1 89  ? -18.59928 -17.94362 9.48480  1.000 37.36606  ? 85  ILE A CG1 1 
ATOM   630  C  CG2 . ILE A 1 89  ? -16.51469 -17.66312 8.11414  1.000 32.99936  ? 85  ILE A CG2 1 
ATOM   631  C  CD1 . ILE A 1 89  ? -18.53680 -16.62860 10.22928 1.000 32.39773  ? 85  ILE A CD1 1 
ATOM   632  N  N   . ARG A 1 90  ? -18.56038 -17.50166 4.94242  1.000 29.95140  ? 86  ARG A N   1 
ATOM   633  C  CA  . ARG A 1 90  ? -18.10462 -17.39431 3.55951  1.000 35.07152  ? 86  ARG A CA  1 
ATOM   634  C  C   . ARG A 1 90  ? -18.55154 -16.07921 2.93584  1.000 30.62631  ? 86  ARG A C   1 
ATOM   635  O  O   . ARG A 1 90  ? -17.81486 -15.47466 2.14723  1.000 30.41586  ? 86  ARG A O   1 
ATOM   636  C  CB  . ARG A 1 90  ? -18.61985 -18.57586 2.73573  1.000 37.22475  ? 86  ARG A CB  1 
ATOM   637  C  CG  . ARG A 1 90  ? -17.62041 -19.71150 2.57002  1.000 39.70441  ? 86  ARG A CG  1 
ATOM   638  C  CD  . ARG A 1 90  ? -18.32130 -21.06399 2.55576  1.000 54.36676  ? 86  ARG A CD  1 
ATOM   639  N  NE  . ARG A 1 90  ? -17.48092 -22.14544 3.05957  1.000 48.71540  ? 86  ARG A NE  1 
ATOM   640  C  CZ  . ARG A 1 90  ? -16.41785 -22.63614 2.43574  1.000 45.83642  ? 86  ARG A CZ  1 
ATOM   641  N  NH1 . ARG A 1 90  ? -16.02741 -22.17144 1.26012  1.000 49.46037  ? 86  ARG A NH1 1 
ATOM   642  N  NH2 . ARG A 1 90  ? -15.73273 -23.62435 3.00378  1.000 42.27311  ? 86  ARG A NH2 1 
ATOM   643  N  N   . GLU A 1 91  ? -19.75920 -15.62286 3.27593  1.000 28.42708  ? 87  GLU A N   1 
ATOM   644  C  CA  . GLU A 1 91  ? -20.23837 -14.33889 2.77523  1.000 26.59118  ? 87  GLU A CA  1 
ATOM   645  C  C   . GLU A 1 91  ? -19.37367 -13.19653 3.29288  1.000 22.67130  ? 87  GLU A C   1 
ATOM   646  O  O   . GLU A 1 91  ? -18.99278 -12.29682 2.53502  1.000 26.11502  ? 87  GLU A O   1 
ATOM   647  C  CB  . GLU A 1 91  ? -21.70104 -14.13647 3.17403  1.000 25.02848  ? 87  GLU A CB  1 
ATOM   648  C  CG  . GLU A 1 91  ? -22.21468 -12.72215 2.96391  1.000 18.33605  ? 87  GLU A CG  1 
ATOM   649  C  CD  . GLU A 1 91  ? -22.21244 -12.31482 1.50458  1.000 28.78852  ? 87  GLU A CD  1 
ATOM   650  O  OE1 . GLU A 1 91  ? -22.70272 -13.09871 0.66406  1.000 33.32233  ? 87  GLU A OE1 1 
ATOM   651  O  OE2 . GLU A 1 91  ? -21.71890 -11.20995 1.19593  1.000 36.95061  ? 87  GLU A OE2 1 
ATOM   652  N  N   . ALA A 1 92  ? -19.05199 -13.21877 4.58910  1.000 25.06122  ? 88  ALA A N   1 
ATOM   653  C  CA  . ALA A 1 92  ? -18.17643 -12.19596 5.15054  1.000 31.30087  ? 88  ALA A CA  1 
ATOM   654  C  C   . ALA A 1 92  ? -16.79597 -12.24394 4.51035  1.000 19.98288  ? 88  ALA A C   1 
ATOM   655  O  O   . ALA A 1 92  ? -16.19380 -11.19886 4.24127  1.000 19.75487  ? 88  ALA A O   1 
ATOM   656  C  CB  . ALA A 1 92  ? -18.07274 -12.36548 6.66595  1.000 26.79484  ? 88  ALA A CB  1 
ATOM   657  N  N   . PHE A 1 93  ? -16.28215 -13.45121 4.25515  1.000 30.65434  ? 89  PHE A N   1 
ATOM   658  C  CA  . PHE A 1 93  ? -14.98376 -13.58828 3.60112  1.000 19.99885  ? 89  PHE A CA  1 
ATOM   659  C  C   . PHE A 1 93  ? -14.98304 -12.93152 2.22666  1.000 22.37389  ? 89  PHE A C   1 
ATOM   660  O  O   . PHE A 1 93  ? -14.02354 -12.24218 1.86206  1.000 18.31898  ? 89  PHE A O   1 
ATOM   661  C  CB  . PHE A 1 93  ? -14.60960 -15.06589 3.48572  1.000 20.94271  ? 89  PHE A CB  1 
ATOM   662  C  CG  . PHE A 1 93  ? -13.19834 -15.30233 3.02315  1.000 20.63111  ? 89  PHE A CG  1 
ATOM   663  C  CD1 . PHE A 1 93  ? -12.13065 -15.12295 3.88817  1.000 22.70888  ? 89  PHE A CD1 1 
ATOM   664  C  CD2 . PHE A 1 93  ? -12.93945 -15.69402 1.72010  1.000 19.43614  ? 89  PHE A CD2 1 
ATOM   665  C  CE1 . PHE A 1 93  ? -10.83244 -15.34252 3.46429  1.000 22.48334  ? 89  PHE A CE1 1 
ATOM   666  C  CE2 . PHE A 1 93  ? -11.64261 -15.91030 1.28970  1.000 26.18427  ? 89  PHE A CE2 1 
ATOM   667  C  CZ  . PHE A 1 93  ? -10.58885 -15.73254 2.16285  1.000 15.67613  ? 89  PHE A CZ  1 
ATOM   668  N  N   . ARG A 1 94  ? -16.05505 -13.12772 1.45240  1.000 22.91188  ? 90  ARG A N   1 
ATOM   669  C  CA  . ARG A 1 94  ? -16.12784 -12.53304 0.12116  1.000 27.26839  ? 90  ARG A CA  1 
ATOM   670  C  C   . ARG A 1 94  ? -16.09330 -11.01229 0.17919  1.000 19.14904  ? 90  ARG A C   1 
ATOM   671  O  O   . ARG A 1 94  ? -15.60685 -10.36786 -0.75678 1.000 23.24976  ? 90  ARG A O   1 
ATOM   672  C  CB  . ARG A 1 94  ? -17.39301 -12.99864 -0.59988 1.000 27.11002  ? 90  ARG A CB  1 
ATOM   673  C  CG  . ARG A 1 94  ? -17.37094 -14.45518 -1.02357 1.000 28.87825  ? 90  ARG A CG  1 
ATOM   674  C  CD  . ARG A 1 94  ? -18.54926 -14.77498 -1.92859 1.000 32.19025  ? 90  ARG A CD  1 
ATOM   675  N  NE  . ARG A 1 94  ? -19.81661 -14.76652 -1.20786 1.000 31.88759  ? 90  ARG A NE  1 
ATOM   676  C  CZ  . ARG A 1 94  ? -20.35115 -15.82862 -0.62116 1.000 38.65983  ? 90  ARG A CZ  1 
ATOM   677  N  NH1 . ARG A 1 94  ? -19.74890 -17.00650 -0.64327 1.000 26.86340  ? 90  ARG A NH1 1 
ATOM   678  N  NH2 . ARG A 1 94  ? -21.52058 -15.70663 0.00082  1.000 32.02669  ? 90  ARG A NH2 1 
ATOM   679  N  N   . VAL A 1 95  ? -16.60275 -10.42224 1.26209  1.000 19.53597  ? 91  VAL A N   1 
ATOM   680  C  CA  . VAL A 1 95  ? -16.58930 -8.96817  1.38744  1.000 20.09090  ? 91  VAL A CA  1 
ATOM   681  C  C   . VAL A 1 95  ? -15.16335 -8.46300  1.56837  1.000 22.83596  ? 91  VAL A C   1 
ATOM   682  O  O   . VAL A 1 95  ? -14.76315 -7.45932  0.96618  1.000 18.84983  ? 91  VAL A O   1 
ATOM   683  C  CB  . VAL A 1 95  ? -17.50319 -8.52659  2.54401  1.000 24.27982  ? 91  VAL A CB  1 
ATOM   684  C  CG1 . VAL A 1 95  ? -17.40832 -7.02087  2.75883  1.000 26.28715  ? 91  VAL A CG1 1 
ATOM   685  C  CG2 . VAL A 1 95  ? -18.93783 -8.94624  2.26638  1.000 22.96024  ? 91  VAL A CG2 1 
ATOM   686  N  N   . PHE A 1 96  ? -14.37206 -9.14878  2.39508  1.000 25.61121  ? 92  PHE A N   1 
ATOM   687  C  CA  . PHE A 1 96  ? -12.96320 -8.79229  2.52880  1.000 23.53802  ? 92  PHE A CA  1 
ATOM   688  C  C   . PHE A 1 96  ? -12.19289 -9.14552  1.26199  1.000 21.72347  ? 92  PHE A C   1 
ATOM   689  O  O   . PHE A 1 96  ? -11.46890 -8.30945  0.70680  1.000 29.95774  ? 92  PHE A O   1 
ATOM   690  C  CB  . PHE A 1 96  ? -12.35413 -9.49839  3.73996  1.000 17.66595  ? 92  PHE A CB  1 
ATOM   691  C  CG  . PHE A 1 96  ? -12.90475 -9.03373  5.05905  1.000 24.43332  ? 92  PHE A CG  1 
ATOM   692  C  CD1 . PHE A 1 96  ? -12.42152 -7.88464  5.66156  1.000 27.21359  ? 92  PHE A CD1 1 
ATOM   693  C  CD2 . PHE A 1 96  ? -13.89305 -9.75793  5.70684  1.000 18.36876  ? 92  PHE A CD2 1 
ATOM   694  C  CE1 . PHE A 1 96  ? -12.92231 -7.45859  6.87963  1.000 29.79561  ? 92  PHE A CE1 1 
ATOM   695  C  CE2 . PHE A 1 96  ? -14.39727 -9.33747  6.92522  1.000 23.36933  ? 92  PHE A CE2 1 
ATOM   696  C  CZ  . PHE A 1 96  ? -13.91070 -8.18639  7.51169  1.000 31.77682  ? 92  PHE A CZ  1 
ATOM   697  N  N   . ASP A 1 97  ? -12.34346 -10.38492 0.78874  1.000 22.98893  ? 93  ASP A N   1 
ATOM   698  C  CA  . ASP A 1 97  ? -11.66055 -10.87642 -0.40934 1.000 21.88385  ? 93  ASP A CA  1 
ATOM   699  C  C   . ASP A 1 97  ? -12.33434 -10.28287 -1.64668 1.000 24.28970  ? 93  ASP A C   1 
ATOM   700  O  O   . ASP A 1 97  ? -13.10185 -10.93664 -2.36031 1.000 27.32404  ? 93  ASP A O   1 
ATOM   701  C  CB  . ASP A 1 97  ? -11.68528 -12.40001 -0.43270 1.000 18.82874  ? 93  ASP A CB  1 
ATOM   702  C  CG  . ASP A 1 97  ? -10.81204 -12.98545 -1.52054 1.000 23.36789  ? 93  ASP A CG  1 
ATOM   703  O  OD1 . ASP A 1 97  ? -9.87404  -12.29914 -1.97868 1.000 19.53693  ? 93  ASP A OD1 1 
ATOM   704  O  OD2 . ASP A 1 97  ? -11.06076 -14.14459 -1.91294 1.000 20.31686  ? 93  ASP A OD2 1 
ATOM   705  N  N   . LYS A 1 98  ? -12.01921 -9.01149  -1.91551 1.000 30.85391  ? 94  LYS A N   1 
ATOM   706  C  CA  . LYS A 1 98  ? -12.71382 -8.28938  -2.97820 1.000 34.56726  ? 94  LYS A CA  1 
ATOM   707  C  C   . LYS A 1 98  ? -12.31647 -8.79145  -4.36257 1.000 34.83457  ? 94  LYS A C   1 
ATOM   708  O  O   . LYS A 1 98  ? -13.15941 -8.86289  -5.26444 1.000 35.61606  ? 94  LYS A O   1 
ATOM   709  C  CB  . LYS A 1 98  ? -12.45350 -6.79077  -2.85018 1.000 37.28093  ? 94  LYS A CB  1 
ATOM   710  C  CG  . LYS A 1 98  ? -13.26167 -6.11872  -1.74746 1.000 32.45453  ? 94  LYS A CG  1 
ATOM   711  C  CD  . LYS A 1 98  ? -14.69637 -5.89564  -2.20202 1.000 44.46221  ? 94  LYS A CD  1 
ATOM   712  C  CE  . LYS A 1 98  ? -15.51200 -5.14869  -1.16307 1.000 45.94566  ? 94  LYS A CE  1 
ATOM   713  N  NZ  . LYS A 1 98  ? -14.65397 -4.54397  -0.11042 1.000 40.89633  ? 94  LYS A NZ  1 
ATOM   714  N  N   . ASP A 1 99  ? -11.04458 -9.13601  -4.56254 1.000 26.23231  ? 95  ASP A N   1 
ATOM   715  C  CA  . ASP A 1 99  ? -10.65707 -9.69727  -5.85082 1.000 26.57681  ? 95  ASP A CA  1 
ATOM   716  C  C   . ASP A 1 99  ? -10.95223 -11.18918 -5.95738 1.000 22.99607  ? 95  ASP A C   1 
ATOM   717  O  O   . ASP A 1 99  ? -10.77706 -11.76364 -7.03739 1.000 22.32018  ? 95  ASP A O   1 
ATOM   718  C  CB  . ASP A 1 99  ? -9.17525  -9.41519  -6.13993 1.000 37.74586  ? 95  ASP A CB  1 
ATOM   719  C  CG  . ASP A 1 99  ? -8.22770  -10.13379 -5.19082 1.000 29.39707  ? 95  ASP A CG  1 
ATOM   720  O  OD1 . ASP A 1 99  ? -8.68193  -10.90980 -4.32378 1.000 32.26728  ? 95  ASP A OD1 1 
ATOM   721  O  OD2 . ASP A 1 99  ? -7.00538  -9.91520  -5.31993 1.000 31.10010  ? 95  ASP A OD2 1 
ATOM   722  N  N   . GLY A 1 100 ? -11.39031 -11.82285 -4.87014 1.000 22.67087  ? 96  GLY A N   1 
ATOM   723  C  CA  . GLY A 1 100 ? -11.83119 -13.20374 -4.90395 1.000 23.24850  ? 96  GLY A CA  1 
ATOM   724  C  C   . GLY A 1 100 ? -10.74583 -14.24754 -5.02961 1.000 23.80516  ? 96  GLY A C   1 
ATOM   725  O  O   . GLY A 1 100 ? -11.06361 -15.41871 -5.25691 1.000 17.41509  ? 96  GLY A O   1 
ATOM   726  N  N   . ASN A 1 101 ? -9.47621  -13.87520 -4.87592 1.000 22.30597  ? 97  ASN A N   1 
ATOM   727  C  CA  . ASN A 1 101 ? -8.39181  -14.82896 -5.07860 1.000 15.63728  ? 97  ASN A CA  1 
ATOM   728  C  C   . ASN A 1 101 ? -8.18755  -15.77220 -3.89806 1.000 16.74435  ? 97  ASN A C   1 
ATOM   729  O  O   . ASN A 1 101 ? -7.31421  -16.64350 -3.97097 1.000 21.27347  ? 97  ASN A O   1 
ATOM   730  C  CB  . ASN A 1 101 ? -7.08596  -14.08731 -5.39434 1.000 15.61444  ? 97  ASN A CB  1 
ATOM   731  C  CG  . ASN A 1 101 ? -6.45640  -13.44351 -4.16974 1.000 17.68770  ? 97  ASN A CG  1 
ATOM   732  O  OD1 . ASN A 1 101 ? -7.12983  -13.15713 -3.17989 1.000 18.44934  ? 97  ASN A OD1 1 
ATOM   733  N  ND2 . ASN A 1 101 ? -5.15094  -13.21239 -4.23567 1.000 24.01861  ? 97  ASN A ND2 1 
ATOM   734  N  N   . GLY A 1 102 ? -8.95783  -15.62499 -2.82157 1.000 15.85557  ? 98  GLY A N   1 
ATOM   735  C  CA  . GLY A 1 102 ? -8.87751  -16.52073 -1.68645 1.000 13.53234  ? 98  GLY A CA  1 
ATOM   736  C  C   . GLY A 1 102 ? -8.03567  -16.03364 -0.52697 1.000 21.00610  ? 98  GLY A C   1 
ATOM   737  O  O   . GLY A 1 102 ? -7.96070  -16.72904 0.49395  1.000 20.68749  ? 98  GLY A O   1 
ATOM   738  N  N   . TYR A 1 103 ? -7.40666  -14.86651 -0.64320 1.000 13.95910  ? 99  TYR A N   1 
ATOM   739  C  CA  . TYR A 1 103 ? -6.54191  -14.33584 0.40083  1.000 16.44583  ? 99  TYR A CA  1 
ATOM   740  C  C   . TYR A 1 103 ? -6.88922  -12.87733 0.65068  1.000 15.65666  ? 99  TYR A C   1 
ATOM   741  O  O   . TYR A 1 103 ? -6.91148  -12.07338 -0.28594 1.000 17.62104  ? 99  TYR A O   1 
ATOM   742  C  CB  . TYR A 1 103 ? -5.06616  -14.46943 0.01019  1.000 20.05049  ? 99  TYR A CB  1 
ATOM   743  C  CG  . TYR A 1 103 ? -4.61411  -15.89706 -0.19302 1.000 16.16772  ? 99  TYR A CG  1 
ATOM   744  C  CD1 . TYR A 1 103 ? -4.15561  -16.65842 0.87309  1.000 18.38108  ? 99  TYR A CD1 1 
ATOM   745  C  CD2 . TYR A 1 103 ? -4.65807  -16.48768 -1.45006 1.000 13.86123  ? 99  TYR A CD2 1 
ATOM   746  C  CE1 . TYR A 1 103 ? -3.74170  -17.96474 0.69206  1.000 20.04936  ? 99  TYR A CE1 1 
ATOM   747  C  CE2 . TYR A 1 103 ? -4.24879  -17.79274 -1.64063 1.000 13.98973  ? 99  TYR A CE2 1 
ATOM   748  C  CZ  . TYR A 1 103 ? -3.79145  -18.52659 -0.56536 1.000 18.80703  ? 99  TYR A CZ  1 
ATOM   749  O  OH  . TYR A 1 103 ? -3.38196  -19.82691 -0.74997 1.000 25.05539  ? 99  TYR A OH  1 
ATOM   750  N  N   . ILE A 1 104 ? -7.15683  -12.54015 1.90831  1.000 14.63431  ? 100 ILE A N   1 
ATOM   751  C  CA  . ILE A 1 104 ? -7.41523  -11.15604 2.28983  1.000 20.73824  ? 100 ILE A CA  1 
ATOM   752  C  C   . ILE A 1 104 ? -6.07908  -10.44854 2.47441  1.000 21.91048  ? 100 ILE A C   1 
ATOM   753  O  O   . ILE A 1 104 ? -5.25727  -10.85679 3.30153  1.000 17.38066  ? 100 ILE A O   1 
ATOM   754  C  CB  . ILE A 1 104 ? -8.25672  -11.07531 3.57093  1.000 22.40653  ? 100 ILE A CB  1 
ATOM   755  C  CG1 . ILE A 1 104 ? -9.56212  -11.85488 3.41800  1.000 17.77801  ? 100 ILE A CG1 1 
ATOM   756  C  CG2 . ILE A 1 104 ? -8.54000  -9.62325  3.92927  1.000 22.06289  ? 100 ILE A CG2 1 
ATOM   757  C  CD1 . ILE A 1 104 ? -10.19783 -12.20619 4.74728  1.000 20.47623  ? 100 ILE A CD1 1 
ATOM   758  N  N   . SER A 1 105 ? -5.86109  -9.38918  1.70728  1.000 20.95260  ? 101 SER A N   1 
ATOM   759  C  CA  . SER A 1 105 ? -4.66520  -8.57647  1.84495  1.000 26.17025  ? 101 SER A CA  1 
ATOM   760  C  C   . SER A 1 105 ? -4.90569  -7.45107  2.84368  1.000 21.77461  ? 101 SER A C   1 
ATOM   761  O  O   . SER A 1 105 ? -6.04113  -7.15542  3.22485  1.000 19.08815  ? 101 SER A O   1 
ATOM   762  C  CB  . SER A 1 105 ? -4.24960  -7.99668  0.49328  1.000 26.72323  ? 101 SER A CB  1 
ATOM   763  O  OG  . SER A 1 105 ? -5.24464  -7.12126  -0.00911 1.000 24.26847  ? 101 SER A OG  1 
ATOM   764  N  N   . ALA A 1 106 ? -3.80919  -6.82506  3.27588  1.000 19.56061  ? 102 ALA A N   1 
ATOM   765  C  CA  . ALA A 1 106 ? -3.93327  -5.63734  4.11225  1.000 17.11469  ? 102 ALA A CA  1 
ATOM   766  C  C   . ALA A 1 106 ? -4.64870  -4.52264  3.36246  1.000 16.24203  ? 102 ALA A C   1 
ATOM   767  O  O   . ALA A 1 106 ? -5.40249  -3.74540  3.95900  1.000 23.26646  ? 102 ALA A O   1 
ATOM   768  C  CB  . ALA A 1 106 ? -2.55392  -5.17449  4.58162  1.000 18.71720  ? 102 ALA A CB  1 
ATOM   769  N  N   . ALA A 1 107 ? -4.43018  -4.43791  2.04811  1.000 16.33062  ? 103 ALA A N   1 
ATOM   770  C  CA  . ALA A 1 107 ? -5.10136  -3.42528  1.24116  1.000 22.47614  ? 103 ALA A CA  1 
ATOM   771  C  C   . ALA A 1 107 ? -6.60443  -3.67190  1.18861  1.000 25.16454  ? 103 ALA A C   1 
ATOM   772  O  O   . ALA A 1 107 ? -7.40078  -2.75102  1.40354  1.000 23.67311  ? 103 ALA A O   1 
ATOM   773  C  CB  . ALA A 1 107 ? -4.50618  -3.40021  -0.16655 1.000 25.06298  ? 103 ALA A CB  1 
ATOM   774  N  N   . GLU A 1 108 ? -7.01252  -4.91208  0.89963  1.000 21.08420  ? 104 GLU A N   1 
ATOM   775  C  CA  . GLU A 1 108 ? -8.43583  -5.23884  0.90682  1.000 19.43095  ? 104 GLU A CA  1 
ATOM   776  C  C   . GLU A 1 108 ? -9.04090  -5.01635  2.28461  1.000 20.93984  ? 104 GLU A C   1 
ATOM   777  O  O   . GLU A 1 108 ? -10.15790 -4.49942  2.40725  1.000 27.08392  ? 104 GLU A O   1 
ATOM   778  C  CB  . GLU A 1 108 ? -8.65246  -6.68473  0.46214  1.000 17.18792  ? 104 GLU A CB  1 
ATOM   779  C  CG  . GLU A 1 108 ? -8.55338  -6.89618  -1.03539 1.000 15.02212  ? 104 GLU A CG  1 
ATOM   780  C  CD  . GLU A 1 108 ? -8.47491  -8.36258  -1.41429 1.000 21.54467  ? 104 GLU A CD  1 
ATOM   781  O  OE1 . GLU A 1 108 ? -8.06140  -9.18393  -0.56737 1.000 26.38501  ? 104 GLU A OE1 1 
ATOM   782  O  OE2 . GLU A 1 108 ? -8.82898  -8.69408  -2.56371 1.000 18.91822  ? 104 GLU A OE2 1 
ATOM   783  N  N   . LEU A 1 109 ? -8.31510  -5.40345  3.33420  1.000 20.98875  ? 105 LEU A N   1 
ATOM   784  C  CA  . LEU A 1 109 ? -8.79304  -5.17500  4.69158  1.000 20.91995  ? 105 LEU A CA  1 
ATOM   785  C  C   . LEU A 1 109 ? -8.87254  -3.68491  4.99787  1.000 29.31339  ? 105 LEU A C   1 
ATOM   786  O  O   . LEU A 1 109 ? -9.82388  -3.22478  5.64025  1.000 29.79141  ? 105 LEU A O   1 
ATOM   787  C  CB  . LEU A 1 109 ? -7.87774  -5.89258  5.68114  1.000 22.17156  ? 105 LEU A CB  1 
ATOM   788  C  CG  . LEU A 1 109 ? -8.22718  -5.84434  7.16547  1.000 26.93262  ? 105 LEU A CG  1 
ATOM   789  C  CD1 . LEU A 1 109 ? -9.70650  -6.09295  7.38447  1.000 33.22213  ? 105 LEU A CD1 1 
ATOM   790  C  CD2 . LEU A 1 109 ? -7.40527  -6.87683  7.91380  1.000 30.66873  ? 105 LEU A CD2 1 
ATOM   791  N  N   . ARG A 1 110 ? -7.87957  -2.91615  4.54244  1.000 26.58708  ? 106 ARG A N   1 
ATOM   792  C  CA  . ARG A 1 110 ? -7.93538  -1.46197  4.66464  1.000 33.19352  ? 106 ARG A CA  1 
ATOM   793  C  C   . ARG A 1 110 ? -9.18192  -0.90413  3.98717  1.000 28.32039  ? 106 ARG A C   1 
ATOM   794  O  O   . ARG A 1 110 ? -9.86803  -0.03465  4.53779  1.000 28.18550  ? 106 ARG A O   1 
ATOM   795  C  CB  . ARG A 1 110 ? -6.67141  -0.84559  4.06041  1.000 30.91950  ? 106 ARG A CB  1 
ATOM   796  C  CG  . ARG A 1 110 ? -6.80875  0.60514   3.62135  1.000 34.35228  ? 106 ARG A CG  1 
ATOM   797  C  CD  . ARG A 1 110 ? -6.99958  1.55785   4.79229  1.000 42.17805  ? 106 ARG A CD  1 
ATOM   798  N  NE  . ARG A 1 110 ? -5.72318  2.08689   5.25725  1.000 49.69459  ? 106 ARG A NE  1 
ATOM   799  C  CZ  . ARG A 1 110 ? -5.55692  2.78840   6.37024  1.000 53.34056  ? 106 ARG A CZ  1 
ATOM   800  N  NH1 . ARG A 1 110 ? -6.57356  3.07266   7.16857  1.000 47.27410  ? 106 ARG A NH1 1 
ATOM   801  N  NH2 . ARG A 1 110 ? -4.34015  3.22202   6.68654  1.000 51.58356  ? 106 ARG A NH2 1 
ATOM   802  N  N   . HIS A 1 111 ? -9.48880  -1.39890  2.78509  1.000 24.79438  ? 107 HIS A N   1 
ATOM   803  C  CA  . HIS A 1 111 ? -10.64528 -0.90356  2.04524  1.000 28.25423  ? 107 HIS A CA  1 
ATOM   804  C  C   . HIS A 1 111 ? -11.93756 -1.13391  2.81701  1.000 24.47110  ? 107 HIS A C   1 
ATOM   805  O  O   . HIS A 1 111 ? -12.84522 -0.29468  2.78757  1.000 31.61537  ? 107 HIS A O   1 
ATOM   806  C  CB  . HIS A 1 111 ? -10.71410 -1.57825  0.67588  1.000 30.27113  ? 107 HIS A CB  1 
ATOM   807  C  CG  . HIS A 1 111 ? -9.56981  -1.23162  -0.22496 1.000 28.78778  ? 107 HIS A CG  1 
ATOM   808  N  ND1 . HIS A 1 111 ? -9.36108  -1.85453  -1.43646 1.000 22.56970  ? 107 HIS A ND1 1 
ATOM   809  C  CD2 . HIS A 1 111 ? -8.57064  -0.32758  -0.09024 1.000 27.54629  ? 107 HIS A CD2 1 
ATOM   810  C  CE1 . HIS A 1 111 ? -8.28318  -1.35000  -2.00951 1.000 19.28839  ? 107 HIS A CE1 1 
ATOM   811  N  NE2 . HIS A 1 111 ? -7.78465  -0.42154  -1.21329 1.000 24.49969  ? 107 HIS A NE2 1 
ATOM   812  N  N   . VAL A 1 112 ? -12.03575 -2.26432  3.51834  1.000 22.57643  ? 108 VAL A N   1 
ATOM   813  C  CA  . VAL A 1 112 ? -13.25390 -2.58127  4.25727  1.000 28.94506  ? 108 VAL A CA  1 
ATOM   814  C  C   . VAL A 1 112 ? -13.43197 -1.62401  5.42955  1.000 30.63781  ? 108 VAL A C   1 
ATOM   815  O  O   . VAL A 1 112 ? -14.52015 -1.07743  5.64562  1.000 22.59459  ? 108 VAL A O   1 
ATOM   816  C  CB  . VAL A 1 112 ? -13.23149 -4.04766  4.72380  1.000 32.24323  ? 108 VAL A CB  1 
ATOM   817  C  CG1 . VAL A 1 112 ? -14.38540 -4.31973  5.67943  1.000 27.25100  ? 108 VAL A CG1 1 
ATOM   818  C  CG2 . VAL A 1 112 ? -13.28391 -4.98682  3.52637  1.000 28.65178  ? 108 VAL A CG2 1 
HETATM 819  N  N   . MSE A 1 113 ? -12.37034 -1.40372  6.19913  1.000 23.18392  ? 109 MSE A N   1 
HETATM 820  C  CA  . MSE A 1 113 ? -12.43261 -0.49428  7.33872  1.000 32.28488  ? 109 MSE A CA  1 
HETATM 821  C  C   . MSE A 1 113 ? -12.72457 0.93280   6.89077  1.000 30.91676  ? 109 MSE A C   1 
HETATM 822  O  O   . MSE A 1 113 ? -13.34095 1.70832   7.62134  1.000 34.61198  ? 109 MSE A O   1 
HETATM 823  C  CB  . MSE A 1 113 ? -11.12748 -0.53985  8.13755  1.000 37.52292  ? 109 MSE A CB  1 
HETATM 824  C  CG  . MSE A 1 113 ? -10.62693 -1.94668  8.41733  1.000 38.92003  ? 109 MSE A CG  1 
HETATM 825  SE SE  . MSE A 1 113 ? -11.77303 -2.93050  9.65638  1.000 52.08708  ? 109 MSE A SE  1 
HETATM 826  C  CE  . MSE A 1 113 ? -12.30541 -1.46799  10.82831 1.000 33.61981  ? 109 MSE A CE  1 
ATOM   827  N  N   . THR A 1 114 ? -12.27857 1.27150   5.67918  1.000 26.31155  ? 110 THR A N   1 
ATOM   828  C  CA  . THR A 1 114 ? -12.53907 2.60390   5.14531  1.000 27.93090  ? 110 THR A CA  1 
ATOM   829  C  C   . THR A 1 114 ? -14.01912 2.79099   4.83153  1.000 32.65707  ? 110 THR A C   1 
ATOM   830  O  O   . THR A 1 114 ? -14.58438 3.85893   5.09360  1.000 33.96473  ? 110 THR A O   1 
ATOM   831  C  CB  . THR A 1 114 ? -11.68767 2.84679   3.89829  1.000 34.64312  ? 110 THR A CB  1 
ATOM   832  O  OG1 . THR A 1 114 ? -10.29848 2.81444   4.25140  1.000 29.57069  ? 110 THR A OG1 1 
ATOM   833  C  CG2 . THR A 1 114 ? -12.00969 4.20221   3.28731  1.000 34.53486  ? 110 THR A CG2 1 
ATOM   834  N  N   . ASN A 1 115 ? -14.66725 1.76240   4.27888  1.000 28.84369  ? 111 ASN A N   1 
ATOM   835  C  CA  . ASN A 1 115 ? -16.09519 1.85554   3.99862  1.000 37.72391  ? 111 ASN A CA  1 
ATOM   836  C  C   . ASN A 1 115 ? -16.92988 1.83610   5.27241  1.000 32.74980  ? 111 ASN A C   1 
ATOM   837  O  O   . ASN A 1 115 ? -18.08512 2.27370   5.24852  1.000 34.69333  ? 111 ASN A O   1 
ATOM   838  C  CB  . ASN A 1 115 ? -16.52998 0.72647   3.06256  1.000 21.79228  ? 111 ASN A CB  1 
ATOM   839  C  CG  . ASN A 1 115 ? -17.63504 1.15372   2.11237  1.000 30.94364  ? 111 ASN A CG  1 
ATOM   840  O  OD1 . ASN A 1 115 ? -17.51539 2.16329   1.41878  1.000 26.39966  ? 111 ASN A OD1 1 
ATOM   841  N  ND2 . ASN A 1 115 ? -18.71701 0.38456   2.07566  1.000 30.45160  ? 111 ASN A ND2 1 
ATOM   842  N  N   . LEU A 1 116 ? -16.37591 1.33971   6.37703  1.000 33.26281  ? 112 LEU A N   1 
ATOM   843  C  CA  . LEU A 1 116 ? -16.98370 1.48527   7.69176  1.000 32.52165  ? 112 LEU A CA  1 
ATOM   844  C  C   . LEU A 1 116 ? -16.60613 2.80215   8.36187  1.000 39.93306  ? 112 LEU A C   1 
ATOM   845  O  O   . LEU A 1 116 ? -16.93517 3.00571   9.53487  1.000 36.72423  ? 112 LEU A O   1 
ATOM   846  C  CB  . LEU A 1 116 ? -16.59410 0.30769   8.59050  1.000 36.50922  ? 112 LEU A CB  1 
ATOM   847  C  CG  . LEU A 1 116 ? -17.19232 -1.05384  8.23048  1.000 40.62024  ? 112 LEU A CG  1 
ATOM   848  C  CD1 . LEU A 1 116 ? -16.36916 -2.18404  8.82504  1.000 34.12381  ? 112 LEU A CD1 1 
ATOM   849  C  CD2 . LEU A 1 116 ? -18.63271 -1.13704  8.70994  1.000 33.53668  ? 112 LEU A CD2 1 
ATOM   850  N  N   . GLY A 1 117 ? -15.91879 3.69153   7.64610  1.000 34.17549  ? 113 GLY A N   1 
ATOM   851  C  CA  . GLY A 1 117 ? -15.59828 5.01125   8.15206  1.000 42.37096  ? 113 GLY A CA  1 
ATOM   852  C  C   . GLY A 1 117 ? -14.55472 5.06328   9.24335  1.000 48.64467  ? 113 GLY A C   1 
ATOM   853  O  O   . GLY A 1 117 ? -14.41350 6.10474   9.89187  1.000 41.42705  ? 113 GLY A O   1 
ATOM   854  N  N   . GLU A 1 118 ? -13.80901 3.98418   9.46293  1.000 36.86641  ? 114 GLU A N   1 
ATOM   855  C  CA  . GLU A 1 118 ? -12.85724 3.93878   10.56322 1.000 41.29893  ? 114 GLU A CA  1 
ATOM   856  C  C   . GLU A 1 118 ? -11.53889 4.59685   10.17740 1.000 48.55320  ? 114 GLU A C   1 
ATOM   857  O  O   . GLU A 1 118 ? -11.06352 4.45996   9.04637  1.000 46.82922  ? 114 GLU A O   1 
ATOM   858  C  CB  . GLU A 1 118 ? -12.61161 2.49433   10.99664 1.000 41.97112  ? 114 GLU A CB  1 
ATOM   859  C  CG  . GLU A 1 118 ? -12.39779 2.33515   12.49054 1.000 50.11077  ? 114 GLU A CG  1 
ATOM   860  C  CD  . GLU A 1 118 ? -13.40058 3.12923   13.30426 1.000 59.41899  ? 114 GLU A CD  1 
ATOM   861  O  OE1 . GLU A 1 118 ? -14.60670 2.81263   13.23534 1.000 59.15836  ? 114 GLU A OE1 1 
ATOM   862  O  OE2 . GLU A 1 118 ? -12.98345 4.06896   14.01375 1.000 55.61963  ? 114 GLU A OE2 1 
ATOM   863  N  N   . LYS A 1 119 ? -10.95106 5.31588   11.13239 1.000 48.95812  ? 115 LYS A N   1 
ATOM   864  C  CA  . LYS A 1 119 ? -9.65279  5.95921   10.96155 1.000 54.93980  ? 115 LYS A CA  1 
ATOM   865  C  C   . LYS A 1 119 ? -8.58804  5.02847   11.52956 1.000 42.29077  ? 115 LYS A C   1 
ATOM   866  O  O   . LYS A 1 119 ? -8.52186  4.81991   12.74504 1.000 52.37504  ? 115 LYS A O   1 
ATOM   867  C  CB  . LYS A 1 119 ? -9.62353  7.31900   11.65608 1.000 57.91272  ? 115 LYS A CB  1 
ATOM   868  C  CG  . LYS A 1 119 ? -10.17648 8.46850   10.82499 1.000 57.60737  ? 115 LYS A CG  1 
ATOM   869  C  CD  . LYS A 1 119 ? -9.57099  8.50185   9.43154  1.000 55.60834  ? 115 LYS A CD  1 
ATOM   870  C  CE  . LYS A 1 119 ? -10.58712 8.97213   8.40309  1.000 70.64085  ? 115 LYS A CE  1 
ATOM   871  N  NZ  . LYS A 1 119 ? -9.93330  9.40429   7.13675  1.000 61.74955  ? 115 LYS A NZ  1 
ATOM   872  N  N   . LEU A 1 120 ? -7.75834  4.47103   10.65092 1.000 45.09701  ? 116 LEU A N   1 
ATOM   873  C  CA  . LEU A 1 120 ? -6.77017  3.47762   11.04080 1.000 50.94818  ? 116 LEU A CA  1 
ATOM   874  C  C   . LEU A 1 120 ? -5.43852  3.79310   10.37694 1.000 49.21406  ? 116 LEU A C   1 
ATOM   875  O  O   . LEU A 1 120 ? -5.39169  4.30834   9.25711  1.000 45.65526  ? 116 LEU A O   1 
ATOM   876  C  CB  . LEU A 1 120 ? -7.21832  2.06000   10.65467 1.000 54.24066  ? 116 LEU A CB  1 
ATOM   877  C  CG  . LEU A 1 120 ? -8.43542  1.47227   11.37416 1.000 49.72396  ? 116 LEU A CG  1 
ATOM   878  C  CD1 . LEU A 1 120 ? -8.63069  0.01678   10.98218 1.000 49.35896  ? 116 LEU A CD1 1 
ATOM   879  C  CD2 . LEU A 1 120 ? -8.29600  1.60521   12.88123 1.000 58.04057  ? 116 LEU A CD2 1 
ATOM   880  N  N   . THR A 1 121 ? -4.35478  3.47797   11.07915 1.000 45.95658  ? 117 THR A N   1 
ATOM   881  C  CA  . THR A 1 121 ? -3.03121  3.61272   10.49615 1.000 45.12380  ? 117 THR A CA  1 
ATOM   882  C  C   . THR A 1 121 ? -2.70160  2.38592   9.65063  1.000 48.01750  ? 117 THR A C   1 
ATOM   883  O  O   . THR A 1 121 ? -3.34947  1.33971   9.74561  1.000 41.14537  ? 117 THR A O   1 
ATOM   884  C  CB  . THR A 1 121 ? -1.97133  3.79817   11.58321 1.000 52.40661  ? 117 THR A CB  1 
ATOM   885  O  OG1 . THR A 1 121 ? -1.54089  2.51647   12.05863 1.000 47.71189  ? 117 THR A OG1 1 
ATOM   886  C  CG2 . THR A 1 121 ? -2.53628  4.59976   12.74591 1.000 46.87532  ? 117 THR A CG2 1 
ATOM   887  N  N   . ASP A 1 122 ? -1.67690  2.52946   8.80726  1.000 53.43300  ? 118 ASP A N   1 
ATOM   888  C  CA  . ASP A 1 122 ? -1.25305  1.41109   7.97110  1.000 47.79577  ? 118 ASP A CA  1 
ATOM   889  C  C   . ASP A 1 122 ? -0.67809  0.28092   8.81360  1.000 46.22770  ? 118 ASP A C   1 
ATOM   890  O  O   . ASP A 1 122 ? -0.89928  -0.89868  8.51430  1.000 47.50290  ? 118 ASP A O   1 
ATOM   891  C  CB  . ASP A 1 122 ? -0.23234  1.88483   6.93888  1.000 47.76885  ? 118 ASP A CB  1 
ATOM   892  C  CG  . ASP A 1 122 ? -0.81728  2.88010   5.96118  1.000 61.51428  ? 118 ASP A CG  1 
ATOM   893  O  OD1 . ASP A 1 122 ? -1.64375  2.47021   5.11893  1.000 56.79859  ? 118 ASP A OD1 1 
ATOM   894  O  OD2 . ASP A 1 122 ? -0.45526  4.07289   6.03870  1.000 57.11953  ? 118 ASP A OD2 1 
ATOM   895  N  N   . GLU A 1 123 ? 0.06435   0.62090   9.86937  1.000 45.69155  ? 119 GLU A N   1 
ATOM   896  C  CA  . GLU A 1 123 ? 0.57663   -0.40758  10.76696 1.000 49.26061  ? 119 GLU A CA  1 
ATOM   897  C  C   . GLU A 1 123 ? -0.55835  -1.10429  11.50589 1.000 44.18064  ? 119 GLU A C   1 
ATOM   898  O  O   . GLU A 1 123 ? -0.51682  -2.32372  11.70493 1.000 43.07452  ? 119 GLU A O   1 
ATOM   899  C  CB  . GLU A 1 123 ? 1.57149   0.20192   11.75479 1.000 45.55888  ? 119 GLU A CB  1 
ATOM   900  C  CG  . GLU A 1 123 ? 3.00583   -0.26778  11.56151 1.000 46.27273  ? 119 GLU A CG  1 
ATOM   901  C  CD  . GLU A 1 123 ? 3.21432   -1.70328  12.00249 1.000 48.71683  ? 119 GLU A CD  1 
ATOM   902  O  OE1 . GLU A 1 123 ? 3.11067   -1.97297  13.21759 1.000 46.63307  ? 119 GLU A OE1 1 
ATOM   903  O  OE2 . GLU A 1 123 ? 3.48139   -2.56145  11.13494 1.000 55.74698  ? 119 GLU A OE2 1 
ATOM   904  N  N   . GLU A 1 124 ? -1.58549  -0.34840  11.90900 1.000 45.39927  ? 120 GLU A N   1 
ATOM   905  C  CA  . GLU A 1 124 ? -2.72114  -0.94821  12.60431 1.000 47.36703  ? 120 GLU A CA  1 
ATOM   906  C  C   . GLU A 1 124 ? -3.39158  -2.01669  11.75032 1.000 33.45382  ? 120 GLU A C   1 
ATOM   907  O  O   . GLU A 1 124 ? -3.85226  -3.03886  12.27134 1.000 28.66442  ? 120 GLU A O   1 
ATOM   908  C  CB  . GLU A 1 124 ? -3.72748  0.13224   13.00063 1.000 46.70529  ? 120 GLU A CB  1 
ATOM   909  C  CG  . GLU A 1 124 ? -3.31012  0.95499   14.20892 1.000 47.17520  ? 120 GLU A CG  1 
ATOM   910  C  CD  . GLU A 1 124 ? -4.26518  2.09688   14.49776 1.000 50.29528  ? 120 GLU A CD  1 
ATOM   911  O  OE1 . GLU A 1 124 ? -4.91892  2.58240   13.55162 1.000 41.72865  ? 120 GLU A OE1 1 
ATOM   912  O  OE2 . GLU A 1 124 ? -4.36107  2.51006   15.67219 1.000 59.89125  ? 120 GLU A OE2 1 
ATOM   913  N  N   . VAL A 1 125 ? -3.45241  -1.80005  10.43504 1.000 34.98399  ? 121 VAL A N   1 
ATOM   914  C  CA  . VAL A 1 125 ? -3.98690  -2.82139  9.54050  1.000 36.09717  ? 121 VAL A CA  1 
ATOM   915  C  C   . VAL A 1 125 ? -3.05729  -4.02817  9.49838  1.000 31.70062  ? 121 VAL A C   1 
ATOM   916  O  O   . VAL A 1 125 ? -3.51079  -5.17871  9.45946  1.000 29.08736  ? 121 VAL A O   1 
ATOM   917  C  CB  . VAL A 1 125 ? -4.21986  -2.23009  8.13800  1.000 32.71404  ? 121 VAL A CB  1 
ATOM   918  C  CG1 . VAL A 1 125 ? -4.67899  -3.30991  7.17023  1.000 33.51706  ? 121 VAL A CG1 1 
ATOM   919  C  CG2 . VAL A 1 125 ? -5.23184  -1.09537  8.20292  1.000 30.37503  ? 121 VAL A CG2 1 
ATOM   920  N  N   . ASP A 1 126 ? -1.74324  -3.78717  9.51421  1.000 40.29756  ? 122 ASP A N   1 
ATOM   921  C  CA  . ASP A 1 126 ? -0.78749  -4.89003  9.54112  1.000 31.80765  ? 122 ASP A CA  1 
ATOM   922  C  C   . ASP A 1 126 ? -0.92339  -5.70523  10.82063 1.000 32.12698  ? 122 ASP A C   1 
ATOM   923  O  O   . ASP A 1 126 ? -0.84399  -6.93890  10.78974 1.000 36.41907  ? 122 ASP A O   1 
ATOM   924  C  CB  . ASP A 1 126 ? 0.63697   -4.35461  9.39411  1.000 41.22910  ? 122 ASP A CB  1 
ATOM   925  C  CG  . ASP A 1 126 ? 0.88512   -3.72237  8.03932  1.000 42.18938  ? 122 ASP A CG  1 
ATOM   926  O  OD1 . ASP A 1 126 ? 0.31124   -4.20793  7.04159  1.000 45.62174  ? 122 ASP A OD1 1 
ATOM   927  O  OD2 . ASP A 1 126 ? 1.65376   -2.74032  7.97131  1.000 52.77278  ? 122 ASP A OD2 1 
ATOM   928  N  N   . GLU A 1 127 ? -1.12829  -5.03188  11.95706 1.000 33.13439  ? 123 GLU A N   1 
ATOM   929  C  CA  . GLU A 1 127 ? -1.34065  -5.74284  13.21511 1.000 28.36774  ? 123 GLU A CA  1 
ATOM   930  C  C   . GLU A 1 127 ? -2.56997  -6.63762  13.14270 1.000 28.38425  ? 123 GLU A C   1 
ATOM   931  O  O   . GLU A 1 127 ? -2.59370  -7.72418  13.73243 1.000 23.77003  ? 123 GLU A O   1 
ATOM   932  C  CB  . GLU A 1 127 ? -1.48147  -4.74839  14.36848 1.000 32.13655  ? 123 GLU A CB  1 
ATOM   933  C  CG  . GLU A 1 127 ? -0.36372  -3.72539  14.46358 1.000 49.05326  ? 123 GLU A CG  1 
ATOM   934  C  CD  . GLU A 1 127 ? -0.59853  -2.70811  15.56439 1.000 64.53678  ? 123 GLU A CD  1 
ATOM   935  O  OE1 . GLU A 1 127 ? -0.21330  -1.53317  15.38395 1.000 54.38619  ? 123 GLU A OE1 1 
ATOM   936  O  OE2 . GLU A 1 127 ? -1.17628  -3.08217  16.60652 1.000 78.98479  ? 123 GLU A OE2 1 
HETATM 937  N  N   . MSE A 1 128 ? -3.59918  -6.19785  12.42873 1.000 26.24054  ? 124 MSE A N   1 
HETATM 938  C  CA  . MSE A 1 128 ? -4.83218  -6.96237  12.30853 1.000 22.81283  ? 124 MSE A CA  1 
HETATM 939  C  C   . MSE A 1 128 ? -4.61790  -8.20198  11.44319 1.000 22.08766  ? 124 MSE A C   1 
HETATM 940  O  O   . MSE A 1 128 ? -5.08792  -9.28963  11.77886 1.000 18.19860  ? 124 MSE A O   1 
HETATM 941  C  CB  . MSE A 1 128 ? -5.94467  -6.07159  11.74818 1.000 18.61094  ? 124 MSE A CB  1 
HETATM 942  C  CG  . MSE A 1 128 ? -6.33129  -4.95377  12.71281 1.000 26.47359  ? 124 MSE A CG  1 
HETATM 943  SE SE  . MSE A 1 128 ? -7.93966  -3.92898  12.27793 1.000 50.90369  ? 124 MSE A SE  1 
HETATM 944  C  CE  . MSE A 1 128 ? -8.17307  -4.44000  10.42654 1.000 25.23446  ? 124 MSE A CE  1 
ATOM   945  N  N   . ILE A 1 129 ? -3.89280  -8.03391  10.33496 1.000 23.48779  ? 125 ILE A N   1 
ATOM   946  C  CA  . ILE A 1 129 ? -3.52297  -9.17970  9.50577  1.000 22.89255  ? 125 ILE A CA  1 
ATOM   947  C  C   . ILE A 1 129 ? -2.63931  -10.14001 10.29186 1.000 20.26665  ? 125 ILE A C   1 
ATOM   948  O  O   . ILE A 1 129 ? -2.85576  -11.35753 10.28700 1.000 18.06396  ? 125 ILE A O   1 
ATOM   949  C  CB  . ILE A 1 129 ? -2.82795  -8.71092  8.21457  1.000 22.35807  ? 125 ILE A CB  1 
ATOM   950  C  CG1 . ILE A 1 129 ? -3.77850  -7.86518  7.36513  1.000 19.78090  ? 125 ILE A CG1 1 
ATOM   951  C  CG2 . ILE A 1 129 ? -2.30877  -9.90478  7.42638  1.000 27.27652  ? 125 ILE A CG2 1 
ATOM   952  C  CD1 . ILE A 1 129 ? -4.69884  -8.68990  6.48674  1.000 24.66243  ? 125 ILE A CD1 1 
ATOM   953  N  N   . ARG A 1 130 ? -1.63379  -9.59997  10.98677 1.000 26.61022  ? 126 ARG A N   1 
ATOM   954  C  CA  . ARG A 1 130 ? -0.66658  -10.43933 11.68899 1.000 24.68295  ? 126 ARG A CA  1 
ATOM   955  C  C   . ARG A 1 130 ? -1.33993  -11.31835 12.73567 1.000 29.45977  ? 126 ARG A C   1 
ATOM   956  O  O   . ARG A 1 130 ? -0.92895  -12.46450 12.95072 1.000 22.93063  ? 126 ARG A O   1 
ATOM   957  C  CB  . ARG A 1 130 ? 0.40656   -9.56179  12.33266 1.000 24.82348  ? 126 ARG A CB  1 
ATOM   958  C  CG  . ARG A 1 130 ? 1.49561   -9.12026  11.37052 1.000 31.11077  ? 126 ARG A CG  1 
ATOM   959  C  CD  . ARG A 1 130 ? 2.60880   -8.36634  12.08488 1.000 39.82166  ? 126 ARG A CD  1 
ATOM   960  N  NE  . ARG A 1 130 ? 2.52201   -6.92720  11.86196 1.000 43.95827  ? 126 ARG A NE  1 
ATOM   961  C  CZ  . ARG A 1 130 ? 2.26909   -6.03185  12.80705 1.000 39.75153  ? 126 ARG A CZ  1 
ATOM   962  N  NH1 . ARG A 1 130 ? 2.08382   -6.38942  14.06720 1.000 42.45545  ? 126 ARG A NH1 1 
ATOM   963  N  NH2 . ARG A 1 130 ? 2.20303   -4.74450  12.47957 1.000 45.24456  ? 126 ARG A NH2 1 
ATOM   964  N  N   . GLU A 1 131 ? -2.38270  -10.80578 13.39039 1.000 27.44413  ? 127 GLU A N   1 
ATOM   965  C  CA  . GLU A 1 131 ? -3.05698  -11.58620 14.42060 1.000 31.90344  ? 127 GLU A CA  1 
ATOM   966  C  C   . GLU A 1 131 ? -3.94546  -12.67245 13.82923 1.000 27.05954  ? 127 GLU A C   1 
ATOM   967  O  O   . GLU A 1 131 ? -4.11438  -13.73047 14.44540 1.000 31.26367  ? 127 GLU A O   1 
ATOM   968  C  CB  . GLU A 1 131 ? -3.87640  -10.66658 15.32655 1.000 35.82716  ? 127 GLU A CB  1 
ATOM   969  C  CG  . GLU A 1 131 ? -3.07683  -10.05716 16.46944 1.000 40.50873  ? 127 GLU A CG  1 
ATOM   970  C  CD  . GLU A 1 131 ? -1.83141  -10.85865 16.80988 1.000 49.23282  ? 127 GLU A CD  1 
ATOM   971  O  OE1 . GLU A 1 131 ? -1.95971  -11.91989 17.45757 1.000 49.79583  ? 127 GLU A OE1 1 
ATOM   972  O  OE2 . GLU A 1 131 ? -0.72260  -10.42603 16.42933 1.000 48.57294  ? 127 GLU A OE2 1 
ATOM   973  N  N   . ALA A 1 132 ? -4.51865  -12.43644 12.64864 1.000 30.72117  ? 128 ALA A N   1 
ATOM   974  C  CA  . ALA A 1 132 ? -5.31539  -13.46022 11.98642 1.000 23.12246  ? 128 ALA A CA  1 
ATOM   975  C  C   . ALA A 1 132 ? -4.46770  -14.40339 11.14436 1.000 25.25370  ? 128 ALA A C   1 
ATOM   976  O  O   . ALA A 1 132 ? -4.92187  -15.50795 10.82683 1.000 23.31654  ? 128 ALA A O   1 
ATOM   977  C  CB  . ALA A 1 132 ? -6.38878  -12.81067 11.10984 1.000 24.80822  ? 128 ALA A CB  1 
ATOM   978  N  N   . ASP A 1 133 ? -3.25221  -13.99629 10.78678 1.000 21.66229  ? 129 ASP A N   1 
ATOM   979  C  CA  . ASP A 1 133 ? -2.37757  -14.80909 9.95333  1.000 19.96145  ? 129 ASP A CA  1 
ATOM   980  C  C   . ASP A 1 133 ? -1.77686  -15.94516 10.77145 1.000 22.32177  ? 129 ASP A C   1 
ATOM   981  O  O   . ASP A 1 133 ? -1.24759  -15.72250 11.86461 1.000 22.89827  ? 129 ASP A O   1 
ATOM   982  C  CB  . ASP A 1 133 ? -1.27712  -13.93547 9.35101  1.000 25.23048  ? 129 ASP A CB  1 
ATOM   983  C  CG  . ASP A 1 133 ? -0.44740  -14.66562 8.31890  1.000 20.56419  ? 129 ASP A CG  1 
ATOM   984  O  OD1 . ASP A 1 133 ? -0.88694  -15.72706 7.83284  1.000 19.39354  ? 129 ASP A OD1 1 
ATOM   985  O  OD2 . ASP A 1 133 ? 0.63981   -14.15807 7.97552  1.000 21.02881  ? 129 ASP A OD2 1 
ATOM   986  N  N   . ILE A 1 134 ? -1.85826  -17.16287 10.23953 1.000 24.24522  ? 130 ILE A N   1 
ATOM   987  C  CA  . ILE A 1 134 ? -1.36521  -18.34936 10.92044 1.000 20.66973  ? 130 ILE A CA  1 
ATOM   988  C  C   . ILE A 1 134 ? -0.13003  -18.92370 10.23696 1.000 24.95624  ? 130 ILE A C   1 
ATOM   989  O  O   . ILE A 1 134 ? 0.83911   -19.28173 10.90926 1.000 19.44638  ? 130 ILE A O   1 
ATOM   990  C  CB  . ILE A 1 134 ? -2.47567  -19.41676 11.04159 1.000 25.30939  ? 130 ILE A CB  1 
ATOM   991  C  CG1 . ILE A 1 134 ? -3.66085  -18.86231 11.83511 1.000 26.28289  ? 130 ILE A CG1 1 
ATOM   992  C  CG2 . ILE A 1 134 ? -1.93928  -20.68115 11.69686 1.000 20.61626  ? 130 ILE A CG2 1 
ATOM   993  C  CD1 . ILE A 1 134 ? -4.83465  -19.81207 11.92767 1.000 18.61548  ? 130 ILE A CD1 1 
ATOM   994  N  N   . ASP A 1 135 ? -0.13658  -19.01790 8.90656  1.000 22.11487  ? 131 ASP A N   1 
ATOM   995  C  CA  . ASP A 1 135 ? 1.00173   -19.60634 8.21021  1.000 19.34033  ? 131 ASP A CA  1 
ATOM   996  C  C   . ASP A 1 135 ? 2.13104   -18.61404 7.95912  1.000 21.88656  ? 131 ASP A C   1 
ATOM   997  O  O   . ASP A 1 135 ? 3.24113   -19.04029 7.62383  1.000 24.81035  ? 131 ASP A O   1 
ATOM   998  C  CB  . ASP A 1 135 ? 0.55180   -20.23254 6.88609  1.000 18.81783  ? 131 ASP A CB  1 
ATOM   999  C  CG  . ASP A 1 135 ? -0.26075  -19.28084 6.03058  1.000 24.11121  ? 131 ASP A CG  1 
ATOM   1000 O  OD1 . ASP A 1 135 ? -0.15537  -18.05338 6.22700  1.000 14.90411  ? 131 ASP A OD1 1 
ATOM   1001 O  OD2 . ASP A 1 135 ? -1.01576  -19.76466 5.16114  1.000 24.47809  ? 131 ASP A OD2 1 
ATOM   1002 N  N   . GLY A 1 136 ? 1.88180   -17.31662 8.10934  1.000 17.10584  ? 132 GLY A N   1 
ATOM   1003 C  CA  . GLY A 1 136 ? 2.92029   -16.31870 7.96661  1.000 17.28101  ? 132 GLY A CA  1 
ATOM   1004 C  C   . GLY A 1 136 ? 3.11020   -15.75735 6.57646  1.000 21.05893  ? 132 GLY A C   1 
ATOM   1005 O  O   . GLY A 1 136 ? 4.09379   -15.04350 6.34729  1.000 16.91952  ? 132 GLY A O   1 
ATOM   1006 N  N   . ASP A 1 137 ? 2.20634   -16.04556 5.64286  1.000 18.43737  ? 133 ASP A N   1 
ATOM   1007 C  CA  . ASP A 1 137 ? 2.34042   -15.55053 4.27771  1.000 22.41537  ? 133 ASP A CA  1 
ATOM   1008 C  C   . ASP A 1 137 ? 1.96912   -14.07882 4.13172  1.000 19.14243  ? 133 ASP A C   1 
ATOM   1009 O  O   . ASP A 1 137 ? 2.05944   -13.54110 3.02199  1.000 20.65656  ? 133 ASP A O   1 
ATOM   1010 C  CB  . ASP A 1 137 ? 1.49358   -16.40365 3.32600  1.000 19.50110  ? 133 ASP A CB  1 
ATOM   1011 C  CG  . ASP A 1 137 ? -0.00009  -16.18894 3.50894  1.000 17.77932  ? 133 ASP A CG  1 
ATOM   1012 O  OD1 . ASP A 1 137 ? -0.41302  -15.63421 4.55047  1.000 13.74381  ? 133 ASP A OD1 1 
ATOM   1013 O  OD2 . ASP A 1 137 ? -0.76713  -16.58710 2.60717  1.000 18.16871  ? 133 ASP A OD2 1 
ATOM   1014 N  N   . GLY A 1 138 ? 1.55548   -13.41802 5.21063  1.000 15.19303  ? 134 GLY A N   1 
ATOM   1015 C  CA  . GLY A 1 138 ? 1.19693   -12.01770 5.15327  1.000 21.36994  ? 134 GLY A CA  1 
ATOM   1016 C  C   . GLY A 1 138 ? -0.22748  -11.73051 4.73484  1.000 18.91526  ? 134 GLY A C   1 
ATOM   1017 O  O   . GLY A 1 138 ? -0.59603  -10.55401 4.62914  1.000 17.64726  ? 134 GLY A O   1 
ATOM   1018 N  N   . GLN A 1 139 ? -1.03681  -12.75735 4.48325  1.000 17.29699  ? 135 GLN A N   1 
ATOM   1019 C  CA  . GLN A 1 139 ? -2.43931  -12.59574 4.12641  1.000 19.55808  ? 135 GLN A CA  1 
ATOM   1020 C  C   . GLN A 1 139 ? -3.28087  -13.53153 4.98595  1.000 26.62770  ? 135 GLN A C   1 
ATOM   1021 O  O   . GLN A 1 139 ? -2.76083  -14.30472 5.79519  1.000 17.53010  ? 135 GLN A O   1 
ATOM   1022 C  CB  . GLN A 1 139 ? -2.67639  -12.86964 2.63549  1.000 22.56472  ? 135 GLN A CB  1 
ATOM   1023 C  CG  . GLN A 1 139 ? -1.66900  -12.21756 1.70673  1.000 24.98118  ? 135 GLN A CG  1 
ATOM   1024 C  CD  . GLN A 1 139 ? -2.11986  -12.22937 0.26093  1.000 18.36083  ? 135 GLN A CD  1 
ATOM   1025 O  OE1 . GLN A 1 139 ? -2.77816  -11.29879 -0.20440 1.000 22.90240  ? 135 GLN A OE1 1 
ATOM   1026 N  NE2 . GLN A 1 139 ? -1.77327  -13.29094 -0.45761 1.000 14.89904  ? 135 GLN A NE2 1 
ATOM   1027 N  N   . VAL A 1 140 ? -4.59694  -13.46138 4.80207  1.000 16.00558  ? 136 VAL A N   1 
ATOM   1028 C  CA  . VAL A 1 140 ? -5.54796  -14.27007 5.55578  1.000 17.38694  ? 136 VAL A CA  1 
ATOM   1029 C  C   . VAL A 1 140 ? -6.39737  -15.04827 4.56182  1.000 17.55904  ? 136 VAL A C   1 
ATOM   1030 O  O   . VAL A 1 140 ? -7.13686  -14.45042 3.76994  1.000 12.79505  ? 136 VAL A O   1 
ATOM   1031 C  CB  . VAL A 1 140 ? -6.43006  -13.40650 6.47205  1.000 20.22074  ? 136 VAL A CB  1 
ATOM   1032 C  CG1 . VAL A 1 140 ? -7.46407  -14.26555 7.18537  1.000 19.80318  ? 136 VAL A CG1 1 
ATOM   1033 C  CG2 . VAL A 1 140 ? -5.57270  -12.64390 7.47203  1.000 19.59607  ? 136 VAL A CG2 1 
ATOM   1034 N  N   . ASN A 1 141 ? -6.29117  -16.37460 4.59869  1.000 14.51282  ? 137 ASN A N   1 
ATOM   1035 C  CA  . ASN A 1 141 ? -7.11569  -17.22565 3.75500  1.000 22.64769  ? 137 ASN A CA  1 
ATOM   1036 C  C   . ASN A 1 141 ? -8.39704  -17.58390 4.50830  1.000 15.21899  ? 137 ASN A C   1 
ATOM   1037 O  O   . ASN A 1 141 ? -8.66424  -17.06641 5.59627  1.000 14.43165  ? 137 ASN A O   1 
ATOM   1038 C  CB  . ASN A 1 141 ? -6.32507  -18.45312 3.29539  1.000 12.05653  ? 137 ASN A CB  1 
ATOM   1039 C  CG  . ASN A 1 141 ? -5.91102  -19.36739 4.44401  1.000 19.50562  ? 137 ASN A CG  1 
ATOM   1040 O  OD1 . ASN A 1 141 ? -6.39701  -19.25310 5.56961  1.000 19.61522  ? 137 ASN A OD1 1 
ATOM   1041 N  ND2 . ASN A 1 141 ? -5.00245  -20.28895 4.15245  1.000 22.21320  ? 137 ASN A ND2 1 
ATOM   1042 N  N   . TYR A 1 142 ? -9.20047  -18.48803 3.94277  1.000 23.01215  ? 138 TYR A N   1 
ATOM   1043 C  CA  . TYR A 1 142 ? -10.49296 -18.79917 4.54741  1.000 19.73424  ? 138 TYR A CA  1 
ATOM   1044 C  C   . TYR A 1 142 ? -10.33347 -19.52072 5.88055  1.000 20.63953  ? 138 TYR A C   1 
ATOM   1045 O  O   . TYR A 1 142 ? -11.01156 -19.18624 6.85848  1.000 21.97268  ? 138 TYR A O   1 
ATOM   1046 C  CB  . TYR A 1 142 ? -11.34726 -19.63345 3.59566  1.000 24.59226  ? 138 TYR A CB  1 
ATOM   1047 C  CG  . TYR A 1 142 ? -12.76186 -19.78906 4.09896  1.000 27.66358  ? 138 TYR A CG  1 
ATOM   1048 C  CD1 . TYR A 1 142 ? -13.55661 -18.67618 4.34443  1.000 24.32222  ? 138 TYR A CD1 1 
ATOM   1049 C  CD2 . TYR A 1 142 ? -13.28865 -21.04339 4.37116  1.000 31.21607  ? 138 TYR A CD2 1 
ATOM   1050 C  CE1 . TYR A 1 142 ? -14.84583 -18.81114 4.82222  1.000 31.91718  ? 138 TYR A CE1 1 
ATOM   1051 C  CE2 . TYR A 1 142 ? -14.57543 -21.18781 4.84888  1.000 36.32877  ? 138 TYR A CE2 1 
ATOM   1052 C  CZ  . TYR A 1 142 ? -15.34914 -20.06818 5.07452  1.000 33.56032  ? 138 TYR A CZ  1 
ATOM   1053 O  OH  . TYR A 1 142 ? -16.63230 -20.20947 5.55124  1.000 46.15883  ? 138 TYR A OH  1 
ATOM   1054 N  N   . GLU A 1 143 ? -9.45334  -20.52433 5.93702  1.000 19.51605  ? 139 GLU A N   1 
ATOM   1055 C  CA  . GLU A 1 143 ? -9.27579  -21.28330 7.17262  1.000 20.62378  ? 139 GLU A CA  1 
ATOM   1056 C  C   . GLU A 1 143 ? -8.84234  -20.37284 8.31463  1.000 25.92102  ? 139 GLU A C   1 
ATOM   1057 O  O   . GLU A 1 143 ? -9.36772  -20.46105 9.43101  1.000 23.87332  ? 139 GLU A O   1 
ATOM   1058 C  CB  . GLU A 1 143 ? -8.25861  -22.40497 6.95979  1.000 27.93701  ? 139 GLU A CB  1 
ATOM   1059 C  CG  . GLU A 1 143 ? -7.88159  -23.14649 8.23317  1.000 36.50104  ? 139 GLU A CG  1 
ATOM   1060 C  CD  . GLU A 1 143 ? -9.07698  -23.78720 8.91066  1.000 33.41277  ? 139 GLU A CD  1 
ATOM   1061 O  OE1 . GLU A 1 143 ? -9.90786  -24.39493 8.20376  1.000 27.87930  ? 139 GLU A OE1 1 
ATOM   1062 O  OE2 . GLU A 1 143 ? -9.18742  -23.67941 10.14997 1.000 29.27295  ? 139 GLU A OE2 1 
ATOM   1063 N  N   . GLU A 1 144 ? -7.88062  -19.48579 8.04812  1.000 21.52999  ? 140 GLU A N   1 
ATOM   1064 C  CA  . GLU A 1 144 ? -7.49422  -18.48689 9.03853  1.000 21.16852  ? 140 GLU A CA  1 
ATOM   1065 C  C   . GLU A 1 144 ? -8.65825  -17.55696 9.35792  1.000 19.66469  ? 140 GLU A C   1 
ATOM   1066 O  O   . GLU A 1 144 ? -8.82652  -17.12834 10.50595 1.000 26.81502  ? 140 GLU A O   1 
ATOM   1067 C  CB  . GLU A 1 144 ? -6.29093  -17.69396 8.52784  1.000 20.58212  ? 140 GLU A CB  1 
ATOM   1068 C  CG  . GLU A 1 144 ? -5.01508  -18.51511 8.42367  1.000 24.60654  ? 140 GLU A CG  1 
ATOM   1069 C  CD  . GLU A 1 144 ? -3.92953  -17.80367 7.64598  1.000 24.95364  ? 140 GLU A CD  1 
ATOM   1070 O  OE1 . GLU A 1 144 ? -4.27024  -17.08326 6.68625  1.000 26.15675  ? 140 GLU A OE1 1 
ATOM   1071 O  OE2 . GLU A 1 144 ? -2.73813  -17.96899 7.98534  1.000 24.50222  ? 140 GLU A OE2 1 
ATOM   1072 N  N   . PHE A 1 145 ? -9.47615  -17.24026 8.35164  1.000 25.40175  ? 141 PHE A N   1 
ATOM   1073 C  CA  . PHE A 1 145 ? -10.64371 -16.39223 8.57176  1.000 24.46554  ? 141 PHE A CA  1 
ATOM   1074 C  C   . PHE A 1 145 ? -11.66687 -17.08137 9.46689  1.000 27.61178  ? 141 PHE A C   1 
ATOM   1075 O  O   . PHE A 1 145 ? -12.25921 -16.44407 10.34575 1.000 32.14465  ? 141 PHE A O   1 
ATOM   1076 C  CB  . PHE A 1 145 ? -11.26657 -16.01519 7.22680  1.000 19.29788  ? 141 PHE A CB  1 
ATOM   1077 C  CG  . PHE A 1 145 ? -12.36373 -14.99510 7.32444  1.000 23.49190  ? 141 PHE A CG  1 
ATOM   1078 C  CD1 . PHE A 1 145 ? -12.07404 -13.67080 7.60226  1.000 22.80580  ? 141 PHE A CD1 1 
ATOM   1079 C  CD2 . PHE A 1 145 ? -13.68592 -15.35960 7.12206  1.000 22.47556  ? 141 PHE A CD2 1 
ATOM   1080 C  CE1 . PHE A 1 145 ? -13.08176 -12.72935 7.68122  1.000 30.83721  ? 141 PHE A CE1 1 
ATOM   1081 C  CE2 . PHE A 1 145 ? -14.70025 -14.42220 7.20399  1.000 26.16583  ? 141 PHE A CE2 1 
ATOM   1082 C  CZ  . PHE A 1 145 ? -14.39745 -13.10456 7.48628  1.000 25.80164  ? 141 PHE A CZ  1 
ATOM   1083 N  N   . VAL A 1 146 ? -11.88513 -18.38301 9.25940  1.000 23.65382  ? 142 VAL A N   1 
ATOM   1084 C  CA  . VAL A 1 146 ? -12.82267 -19.12803 10.09653 1.000 30.04906  ? 142 VAL A CA  1 
ATOM   1085 C  C   . VAL A 1 146 ? -12.36651 -19.11477 11.54917 1.000 35.97357  ? 142 VAL A C   1 
ATOM   1086 O  O   . VAL A 1 146 ? -13.17124 -18.91786 12.46821 1.000 32.40656  ? 142 VAL A O   1 
ATOM   1087 C  CB  . VAL A 1 146 ? -12.98539 -20.56578 9.56763  1.000 29.20830  ? 142 VAL A CB  1 
ATOM   1088 C  CG1 . VAL A 1 146 ? -13.86850 -21.38039 10.49802 1.000 32.33670  ? 142 VAL A CG1 1 
ATOM   1089 C  CG2 . VAL A 1 146 ? -13.56289 -20.55402 8.16523  1.000 25.79060  ? 142 VAL A CG2 1 
ATOM   1090 N  N   . GLN A 1 147 ? -11.06728 -19.31229 11.77886 1.000 36.54316  ? 143 GLN A N   1 
ATOM   1091 C  CA  . GLN A 1 147 ? -10.53741 -19.32739 13.13625 1.000 35.81827  ? 143 GLN A CA  1 
ATOM   1092 C  C   . GLN A 1 147 ? -10.57090 -17.95119 13.78807 1.000 38.01467  ? 143 GLN A C   1 
ATOM   1093 O  O   . GLN A 1 147 ? -10.58724 -17.86373 15.02066 1.000 48.94525  ? 143 GLN A O   1 
ATOM   1094 C  CB  . GLN A 1 147 ? -9.11025  -19.87682 13.12167 1.000 36.88790  ? 143 GLN A CB  1 
ATOM   1095 C  CG  . GLN A 1 147 ? -9.03682  -21.34462 12.73631 1.000 37.22930  ? 143 GLN A CG  1 
ATOM   1096 C  CD  . GLN A 1 147 ? -7.68889  -21.96760 13.03362 1.000 35.20078  ? 143 GLN A CD  1 
ATOM   1097 O  OE1 . GLN A 1 147 ? -6.94644  -21.49017 13.89040 1.000 38.16656  ? 143 GLN A OE1 1 
ATOM   1098 N  NE2 . GLN A 1 147 ? -7.36361  -23.04057 12.32061 1.000 23.65077  ? 143 GLN A NE2 1 
HETATM 1099 N  N   . MSE A 1 148 ? -10.58309 -16.88429 12.99500 1.000 40.33989  ? 144 MSE A N   1 
HETATM 1100 C  CA  . MSE A 1 148 ? -10.64817 -15.52188 13.51836 1.000 38.48898  ? 144 MSE A CA  1 
HETATM 1101 C  C   . MSE A 1 148 ? -12.08555 -15.13508 13.85372 1.000 46.36844  ? 144 MSE A C   1 
HETATM 1102 O  O   . MSE A 1 148 ? -12.33583 -14.36300 14.78143 1.000 51.24271  ? 144 MSE A O   1 
HETATM 1103 C  CB  . MSE A 1 148 ? -10.05842 -14.53921 12.50391 1.000 34.92473  ? 144 MSE A CB  1 
HETATM 1104 C  CG  . MSE A 1 148 ? -10.09727 -13.07986 12.93090 1.000 35.86473  ? 144 MSE A CG  1 
HETATM 1105 SE SE  . MSE A 1 148 ? -8.57265  -12.55545 14.02820 1.000 87.96154  ? 144 MSE A SE  1 
HETATM 1106 C  CE  . MSE A 1 148 ? -9.52812  -12.02781 15.64396 1.000 61.72051  ? 144 MSE A CE  1 
HETATM 1107 N  N   . MSE A 1 149 ? -13.02172 -15.69678 13.09400 1.000 38.09914  ? 145 MSE A N   1 
HETATM 1108 C  CA  . MSE A 1 149 ? -14.42883 -15.32164 13.17219 1.000 48.11840  ? 145 MSE A CA  1 
HETATM 1109 C  C   . MSE A 1 149 ? -15.20968 -16.19618 14.14490 1.000 47.44623  ? 145 MSE A C   1 
HETATM 1110 O  O   . MSE A 1 149 ? -16.22813 -15.77658 14.69358 1.000 50.80449  ? 145 MSE A O   1 
HETATM 1111 C  CB  . MSE A 1 149 ? -15.06832 -15.40872 11.78860 1.000 29.53473  ? 145 MSE A CB  1 
HETATM 1112 C  CG  . MSE A 1 149 ? -14.81953 -14.19784 10.92118 1.000 46.03880  ? 145 MSE A CG  1 
HETATM 1113 SE SE  . MSE A 1 149 ? -14.84482 -12.50533 11.89492 1.000 82.11054  ? 145 MSE A SE  1 
HETATM 1114 C  CE  . MSE A 1 149 ? -13.76445 -11.42176 10.68129 1.000 55.43667  ? 145 MSE A CE  1 
ATOM   1115 N  N   . THR A 1 150 ? -14.72031 -17.41262 14.35798 1.000 48.83316  ? 146 THR A N   1 
ATOM   1116 C  CA  . THR A 1 150 ? -15.40141 -18.41595 15.16014 1.000 49.38676  ? 146 THR A CA  1 
ATOM   1117 C  C   . THR A 1 150 ? -14.51382 -18.85345 16.31802 1.000 52.71368  ? 146 THR A C   1 
ATOM   1118 O  O   . THR A 1 150 ? -13.34193 -18.47942 16.41596 1.000 58.45759  ? 146 THR A O   1 
ATOM   1119 C  CB  . THR A 1 150 ? -15.78767 -19.63274 14.30664 1.000 44.17415  ? 146 THR A CB  1 
ATOM   1120 O  OG1 . THR A 1 150 ? -14.61242 -20.39605 14.00591 1.000 45.76694  ? 146 THR A OG1 1 
ATOM   1121 C  CG2 . THR A 1 150 ? -16.44415 -19.19073 13.00208 1.000 37.09231  ? 146 THR A CG2 1 
ATOM   1122 N  N   . ALA A 1 151 ? -15.09343 -19.66500 17.19846 1.000 53.91217  ? 147 ALA A N   1 
ATOM   1123 C  CA  . ALA A 1 151 ? -14.37207 -20.24930 18.32432 1.000 58.04057  ? 147 ALA A CA  1 
ATOM   1124 C  C   . ALA A 1 151 ? -13.47357 -21.40273 17.91356 1.000 59.79947  ? 147 ALA A C   1 
ATOM   1125 O  O   . ALA A 1 151 ? -12.95164 -22.09658 18.79805 1.000 59.95652  ? 147 ALA A O   1 
ATOM   1126 C  CB  . ALA A 1 151 ? -15.35975 -20.71500 19.39492 1.000 52.74071  ? 147 ALA A CB  1 
ATOM   1127 N  N   . LYS A 1 152 ? -13.29066 -21.62596 16.61317 1.000 56.41632  ? 148 LYS A N   1 
ATOM   1128 C  CA  . LYS A 1 152 ? -12.40036 -22.68088 16.15159 1.000 56.12054  ? 148 LYS A CA  1 
ATOM   1129 C  C   . LYS A 1 152 ? -10.96818 -22.38224 16.57477 1.000 47.60230  ? 148 LYS A C   1 
ATOM   1130 O  O   . LYS A 1 152 ? -10.49146 -21.25015 16.45294 1.000 56.41475  ? 148 LYS A O   1 
ATOM   1131 C  CB  . LYS A 1 152 ? -12.49029 -22.82047 14.63137 1.000 47.95685  ? 148 LYS A CB  1 
ATOM   1132 C  CG  . LYS A 1 152 ? -12.62041 -24.25537 14.14455 1.000 47.74966  ? 148 LYS A CG  1 
ATOM   1133 C  CD  . LYS A 1 152 ? -13.05062 -24.31104 12.68585 1.000 38.76173  ? 148 LYS A CD  1 
ATOM   1134 C  CE  . LYS A 1 152 ? -11.86949 -24.58100 11.76817 1.000 40.58811  ? 148 LYS A CE  1 
ATOM   1135 N  NZ  . LYS A 1 152 ? -12.26537 -24.57873 10.33240 1.000 43.25524  ? 148 LYS A NZ  1 
ATOM   1136 N  N   . ASN A 1 153 ? -10.28774 -23.41010 17.07776 1.000 58.17637  ? 149 ASN A N   1 
ATOM   1137 C  CA  . ASN A 1 153 ? -8.93936  -23.27652 17.62808 1.000 52.81669  ? 149 ASN A CA  1 
ATOM   1138 C  C   . ASN A 1 153 ? -8.88958  -22.22017 18.72780 1.000 54.79896  ? 149 ASN A C   1 
ATOM   1139 O  O   . ASN A 1 153 ? -9.36752  -22.44515 19.84000 1.000 62.50524  ? 149 ASN A O   1 
ATOM   1140 C  CB  . ASN A 1 153 ? -7.93194  -22.93694 16.52801 1.000 47.83211  ? 149 ASN A CB  1 
ATOM   1141 C  CG  . ASN A 1 153 ? -6.49558  -23.07951 16.99030 1.000 53.39675  ? 149 ASN A CG  1 
ATOM   1142 O  OD1 . ASN A 1 153 ? -5.96227  -24.18654 17.06413 1.000 57.53714  ? 149 ASN A OD1 1 
ATOM   1143 N  ND2 . ASN A 1 153 ? -5.86129  -21.95612 17.30735 1.000 59.75348  ? 149 ASN A ND2 1 
ATOM   1144 N  N   . THR B 1 9   ? -18.89058 -16.54500 27.83085 1.000 56.58168  ? 5   THR B N   1 
ATOM   1145 C  CA  . THR B 1 9   ? -20.20738 -17.00504 27.40263 1.000 62.53567  ? 5   THR B CA  1 
ATOM   1146 C  C   . THR B 1 9   ? -21.31172 -15.98960 27.67344 1.000 67.12579  ? 5   THR B C   1 
ATOM   1147 O  O   . THR B 1 9   ? -21.06898 -14.90691 28.20681 1.000 60.05886  ? 5   THR B O   1 
ATOM   1148 C  CB  . THR B 1 9   ? -20.59035 -18.33412 28.08657 1.000 61.29211  ? 5   THR B CB  1 
ATOM   1149 O  OG1 . THR B 1 9   ? -21.19363 -18.06655 29.35911 1.000 63.70193  ? 5   THR B OG1 1 
ATOM   1150 C  CG2 . THR B 1 9   ? -19.37231 -19.23073 28.25946 1.000 70.53563  ? 5   THR B CG2 1 
ATOM   1151 N  N   . GLU B 1 10  ? -22.53462 -16.36457 27.29365 1.000 57.67491  ? 6   GLU B N   1 
ATOM   1152 C  CA  . GLU B 1 10  ? -23.68179 -15.48478 27.48524 1.000 61.80261  ? 6   GLU B CA  1 
ATOM   1153 C  C   . GLU B 1 10  ? -24.07078 -15.39431 28.95526 1.000 61.81041  ? 6   GLU B C   1 
ATOM   1154 O  O   . GLU B 1 10  ? -24.38134 -14.30662 29.45561 1.000 53.81755  ? 6   GLU B O   1 
ATOM   1155 C  CB  . GLU B 1 10  ? -24.85581 -15.98312 26.64344 1.000 56.56896  ? 6   GLU B CB  1 
ATOM   1156 C  CG  . GLU B 1 10  ? -26.21688 -15.49105 27.09425 1.000 61.33571  ? 6   GLU B CG  1 
ATOM   1157 C  CD  . GLU B 1 10  ? -27.29883 -15.78907 26.07761 1.000 51.38803  ? 6   GLU B CD  1 
ATOM   1158 O  OE1 . GLU B 1 10  ? -26.97173 -16.33985 25.00505 1.000 53.52049  ? 6   GLU B OE1 1 
ATOM   1159 O  OE2 . GLU B 1 10  ? -28.47540 -15.47251 26.34956 1.000 65.81956  ? 6   GLU B OE2 1 
ATOM   1160 N  N   . GLU B 1 11  ? -24.05637 -16.52596 29.66432 1.000 66.85033  ? 7   GLU B N   1 
ATOM   1161 C  CA  . GLU B 1 11  ? -24.42697 -16.51629 31.07524 1.000 62.00354  ? 7   GLU B CA  1 
ATOM   1162 C  C   . GLU B 1 11  ? -23.40881 -15.76038 31.91898 1.000 59.56560  ? 7   GLU B C   1 
ATOM   1163 O  O   . GLU B 1 11  ? -23.77582 -15.15393 32.93224 1.000 55.82623  ? 7   GLU B O   1 
ATOM   1164 C  CB  . GLU B 1 11  ? -24.58858 -17.94719 31.58650 1.000 64.63154  ? 7   GLU B CB  1 
ATOM   1165 C  CG  . GLU B 1 11  ? -25.35276 -18.05603 32.89626 1.000 69.43993  ? 7   GLU B CG  1 
ATOM   1166 C  CD  . GLU B 1 11  ? -25.44378 -19.48363 33.39856 1.000 74.67829  ? 7   GLU B CD  1 
ATOM   1167 O  OE1 . GLU B 1 11  ? -24.43303 -19.99649 33.92376 1.000 87.74641  ? 7   GLU B OE1 1 
ATOM   1168 O  OE2 . GLU B 1 11  ? -26.52547 -20.09451 33.26686 1.000 69.86204  ? 7   GLU B OE2 1 
ATOM   1169 N  N   . GLN B 1 12  ? -22.13191 -15.78487 31.52510 1.000 58.84937  ? 8   GLN B N   1 
ATOM   1170 C  CA  . GLN B 1 12  ? -21.14233 -14.95377 32.20280 1.000 59.74469  ? 8   GLN B CA  1 
ATOM   1171 C  C   . GLN B 1 12  ? -21.46563 -13.47418 32.05632 1.000 58.23117  ? 8   GLN B C   1 
ATOM   1172 O  O   . GLN B 1 12  ? -21.07470 -12.66481 32.90436 1.000 56.07693  ? 8   GLN B O   1 
ATOM   1173 C  CB  . GLN B 1 12  ? -19.73824 -15.23744 31.66322 1.000 53.53068  ? 8   GLN B CB  1 
ATOM   1174 C  CG  . GLN B 1 12  ? -19.26740 -16.67716 31.80653 1.000 64.28718  ? 8   GLN B CG  1 
ATOM   1175 C  CD  . GLN B 1 12  ? -18.00707 -16.95269 31.00473 1.000 65.35689  ? 8   GLN B CD  1 
ATOM   1176 O  OE1 . GLN B 1 12  ? -17.68113 -18.10218 30.71175 1.000 61.68071  ? 8   GLN B OE1 1 
ATOM   1177 N  NE2 . GLN B 1 12  ? -17.30153 -15.89083 30.62902 1.000 66.79094  ? 8   GLN B NE2 1 
ATOM   1178 N  N   . ILE B 1 13  ? -22.18255 -13.10291 30.99806 1.000 62.46808  ? 9   ILE B N   1 
ATOM   1179 C  CA  . ILE B 1 13  ? -22.46776 -11.69556 30.76036 1.000 56.43392  ? 9   ILE B CA  1 
ATOM   1180 C  C   . ILE B 1 13  ? -23.63886 -11.23522 31.61130 1.000 57.79192  ? 9   ILE B C   1 
ATOM   1181 O  O   . ILE B 1 13  ? -23.61280 -10.13932 32.18210 1.000 55.04428  ? 9   ILE B O   1 
ATOM   1182 C  CB  . ILE B 1 13  ? -22.71609 -11.46840 29.26159 1.000 54.51221  ? 9   ILE B CB  1 
ATOM   1183 C  CG1 . ILE B 1 13  ? -21.42509 -11.76195 28.50803 1.000 55.32977  ? 9   ILE B CG1 1 
ATOM   1184 C  CG2 . ILE B 1 13  ? -23.22959 -10.05464 28.99301 1.000 43.88473  ? 9   ILE B CG2 1 
ATOM   1185 C  CD1 . ILE B 1 13  ? -20.46248 -10.62298 28.50406 1.000 55.48371  ? 9   ILE B CD1 1 
ATOM   1186 N  N   . ALA B 1 14  ? -24.67635 -12.06580 31.71987 1.000 61.86482  ? 10  ALA B N   1 
ATOM   1187 C  CA  . ALA B 1 14  ? -25.80471 -11.72959 32.57521 1.000 56.23524  ? 10  ALA B CA  1 
ATOM   1188 C  C   . ALA B 1 14  ? -25.39884 -11.62224 34.03800 1.000 61.82126  ? 10  ALA B C   1 
ATOM   1189 O  O   . ALA B 1 14  ? -26.07395 -10.93023 34.80776 1.000 52.42545  ? 10  ALA B O   1 
ATOM   1190 C  CB  . ALA B 1 14  ? -26.91555 -12.76661 32.40786 1.000 61.97874  ? 10  ALA B CB  1 
ATOM   1191 N  N   . GLU B 1 15  ? -24.31023 -12.28395 34.43633 1.000 53.55105  ? 11  GLU B N   1 
ATOM   1192 C  CA  . GLU B 1 15  ? -23.83808 -12.18667 35.81271 1.000 61.30879  ? 11  GLU B CA  1 
ATOM   1193 C  C   . GLU B 1 15  ? -23.06372 -10.89378 36.03987 1.000 57.45256  ? 11  GLU B C   1 
ATOM   1194 O  O   . GLU B 1 15  ? -23.26719 -10.20988 37.04886 1.000 58.42684  ? 11  GLU B O   1 
ATOM   1195 C  CB  . GLU B 1 15  ? -22.97344 -13.39981 36.15901 1.000 60.65028  ? 11  GLU B CB  1 
ATOM   1196 N  N   . PHE B 1 16  ? -22.16983 -10.54452 35.10913 1.000 61.64837  ? 12  PHE B N   1 
ATOM   1197 C  CA  . PHE B 1 16  ? -21.43741 -9.28610  35.21973 1.000 55.53278  ? 12  PHE B CA  1 
ATOM   1198 C  C   . PHE B 1 16  ? -22.37785 -8.08983  35.15749 1.000 52.10128  ? 12  PHE B C   1 
ATOM   1199 O  O   . PHE B 1 16  ? -22.07337 -7.02921  35.71565 1.000 45.37137  ? 12  PHE B O   1 
ATOM   1200 C  CB  . PHE B 1 16  ? -20.38251 -9.17987  34.11459 1.000 58.38724  ? 12  PHE B CB  1 
ATOM   1201 C  CG  . PHE B 1 16  ? -19.29955 -10.22869 34.18454 1.000 64.85367  ? 12  PHE B CG  1 
ATOM   1202 C  CD1 . PHE B 1 16  ? -19.17968 -11.07066 35.28102 1.000 69.72816  ? 12  PHE B CD1 1 
ATOM   1203 C  CD2 . PHE B 1 16  ? -18.39638 -10.36680 33.14306 1.000 65.11693  ? 12  PHE B CD2 1 
ATOM   1204 C  CE1 . PHE B 1 16  ? -18.18159 -12.02872 35.33298 1.000 72.98090  ? 12  PHE B CE1 1 
ATOM   1205 C  CE2 . PHE B 1 16  ? -17.39826 -11.32091 33.18986 1.000 64.25703  ? 12  PHE B CE2 1 
ATOM   1206 C  CZ  . PHE B 1 16  ? -17.29059 -12.15261 34.28560 1.000 70.23562  ? 12  PHE B CZ  1 
ATOM   1207 N  N   . LYS B 1 17  ? -23.51816 -8.23832  34.47867 1.000 53.20558  ? 13  LYS B N   1 
ATOM   1208 C  CA  . LYS B 1 17  ? -24.51296 -7.17186  34.45393 1.000 50.13819  ? 13  LYS B CA  1 
ATOM   1209 C  C   . LYS B 1 17  ? -25.22261 -7.05461  35.79692 1.000 45.62077  ? 13  LYS B C   1 
ATOM   1210 O  O   . LYS B 1 17  ? -25.50811 -5.94381  36.26076 1.000 48.93189  ? 13  LYS B O   1 
ATOM   1211 C  CB  . LYS B 1 17  ? -25.51473 -7.42442  33.32703 1.000 50.26272  ? 13  LYS B CB  1 
ATOM   1212 C  CG  . LYS B 1 17  ? -26.74235 -6.53137  33.35434 1.000 52.49055  ? 13  LYS B CG  1 
ATOM   1213 C  CD  . LYS B 1 17  ? -27.27111 -6.29762  31.94775 1.000 54.88239  ? 13  LYS B CD  1 
ATOM   1214 C  CE  . LYS B 1 17  ? -27.94475 -7.54398  31.39525 1.000 57.02453  ? 13  LYS B CE  1 
ATOM   1215 N  NZ  . LYS B 1 17  ? -27.97065 -7.55006  29.90468 1.000 55.32276  ? 13  LYS B NZ  1 
ATOM   1216 N  N   . GLU B 1 18  ? -25.51450 -8.19035  36.43689 1.000 46.71556  ? 14  GLU B N   1 
ATOM   1217 C  CA  . GLU B 1 18  ? -26.09976 -8.15145  37.77282 1.000 51.79181  ? 14  GLU B CA  1 
ATOM   1218 C  C   . GLU B 1 18  ? -25.12642 -7.54971  38.77834 1.000 46.89731  ? 14  GLU B C   1 
ATOM   1219 O  O   . GLU B 1 18  ? -25.51666 -6.72610  39.61396 1.000 44.10597  ? 14  GLU B O   1 
ATOM   1220 C  CB  . GLU B 1 18  ? -26.52046 -9.55573  38.20527 1.000 53.21346  ? 14  GLU B CB  1 
ATOM   1221 N  N   . ALA B 1 19  ? -23.85095 -7.94287  38.70572 1.000 50.84030  ? 15  ALA B N   1 
ATOM   1222 C  CA  . ALA B 1 19  ? -22.84602 -7.37663  39.60097 1.000 54.18202  ? 15  ALA B CA  1 
ATOM   1223 C  C   . ALA B 1 19  ? -22.69424 -5.87712  39.38139 1.000 48.19298  ? 15  ALA B C   1 
ATOM   1224 O  O   . ALA B 1 19  ? -22.50542 -5.11648  40.33857 1.000 47.81803  ? 15  ALA B O   1 
ATOM   1225 C  CB  . ALA B 1 19  ? -21.50663 -8.08538  39.40233 1.000 49.12576  ? 15  ALA B CB  1 
ATOM   1226 N  N   . PHE B 1 20  ? -22.77091 -5.43530  38.12375 1.000 47.96373  ? 16  PHE B N   1 
ATOM   1227 C  CA  . PHE B 1 20  ? -22.72395 -4.00656  37.83185 1.000 49.10919  ? 16  PHE B CA  1 
ATOM   1228 C  C   . PHE B 1 20  ? -23.88359 -3.27276  38.49480 1.000 43.19327  ? 16  PHE B C   1 
ATOM   1229 O  O   . PHE B 1 20  ? -23.73191 -2.12943  38.94120 1.000 44.24427  ? 16  PHE B O   1 
ATOM   1230 C  CB  . PHE B 1 20  ? -22.74045 -3.78784  36.31728 1.000 43.48327  ? 16  PHE B CB  1 
ATOM   1231 C  CG  . PHE B 1 20  ? -22.50500 -2.36258  35.90103 1.000 39.66638  ? 16  PHE B CG  1 
ATOM   1232 C  CD1 . PHE B 1 20  ? -23.55933 -1.46993  35.80395 1.000 35.64344  ? 16  PHE B CD1 1 
ATOM   1233 C  CD2 . PHE B 1 20  ? -21.23145 -1.92112  35.58708 1.000 41.23742  ? 16  PHE B CD2 1 
ATOM   1234 C  CE1 . PHE B 1 20  ? -23.34536 -0.16129  35.41736 1.000 45.40161  ? 16  PHE B CE1 1 
ATOM   1235 C  CE2 . PHE B 1 20  ? -21.01139 -0.61415  35.19573 1.000 43.69608  ? 16  PHE B CE2 1 
ATOM   1236 C  CZ  . PHE B 1 20  ? -22.06968 0.26681   35.11253 1.000 45.49351  ? 16  PHE B CZ  1 
ATOM   1237 N  N   . SER B 1 21  ? -25.04924 -3.92005  38.57729 1.000 46.44188  ? 17  SER B N   1 
ATOM   1238 C  CA  . SER B 1 21  ? -26.22712 -3.25954  39.12942 1.000 48.06662  ? 17  SER B CA  1 
ATOM   1239 C  C   . SER B 1 21  ? -26.15117 -3.12926  40.64592 1.000 38.88915  ? 17  SER B C   1 
ATOM   1240 O  O   . SER B 1 21  ? -26.77852 -2.22985  41.21692 1.000 45.73019  ? 17  SER B O   1 
ATOM   1241 C  CB  . SER B 1 21  ? -27.49054 -4.01581  38.72184 1.000 43.95180  ? 17  SER B CB  1 
ATOM   1242 O  OG  . SER B 1 21  ? -27.59839 -4.10157  37.31067 1.000 46.35086  ? 17  SER B OG  1 
ATOM   1243 N  N   . LEU B 1 22  ? -25.40583 -4.01303  41.31639 1.000 48.21517  ? 18  LEU B N   1 
ATOM   1244 C  CA  . LEU B 1 22  ? -25.19782 -3.84772  42.75144 1.000 53.73115  ? 18  LEU B CA  1 
ATOM   1245 C  C   . LEU B 1 22  ? -24.43606 -2.56284  43.04575 1.000 43.87414  ? 18  LEU B C   1 
ATOM   1246 O  O   . LEU B 1 22  ? -24.71749 -1.87530  44.03409 1.000 44.33559  ? 18  LEU B O   1 
ATOM   1247 C  CB  . LEU B 1 22  ? -24.44801 -5.04854  43.32691 1.000 53.66931  ? 18  LEU B CB  1 
ATOM   1248 C  CG  . LEU B 1 22  ? -25.27700 -6.24611  43.79632 1.000 57.39761  ? 18  LEU B CG  1 
ATOM   1249 C  CD1 . LEU B 1 22  ? -25.44696 -7.26129  42.68034 1.000 60.02760  ? 18  LEU B CD1 1 
ATOM   1250 C  CD2 . LEU B 1 22  ? -24.65845 -6.88234  45.03206 1.000 63.04759  ? 18  LEU B CD2 1 
ATOM   1251 N  N   . PHE B 1 23  ? -23.46390 -2.22310  42.19774 1.000 44.12170  ? 19  PHE B N   1 
ATOM   1252 C  CA  . PHE B 1 23  ? -22.69618 -1.00103  42.39963 1.000 41.37732  ? 19  PHE B CA  1 
ATOM   1253 C  C   . PHE B 1 23  ? -23.40514 0.21501   41.82010 1.000 45.39515  ? 19  PHE B C   1 
ATOM   1254 O  O   . PHE B 1 23  ? -23.24336 1.32550   42.33748 1.000 38.34703  ? 19  PHE B O   1 
ATOM   1255 C  CB  . PHE B 1 23  ? -21.30561 -1.14768  41.78050 1.000 36.68881  ? 19  PHE B CB  1 
ATOM   1256 C  CG  . PHE B 1 23  ? -20.35054 -1.95205  42.61725 1.000 43.43108  ? 19  PHE B CG  1 
ATOM   1257 C  CD1 . PHE B 1 23  ? -19.50131 -1.32975  43.51641 1.000 48.15508  ? 19  PHE B CD1 1 
ATOM   1258 C  CD2 . PHE B 1 23  ? -20.30406 -3.33320  42.50445 1.000 41.22458  ? 19  PHE B CD2 1 
ATOM   1259 C  CE1 . PHE B 1 23  ? -18.62111 -2.06727  44.28635 1.000 48.68909  ? 19  PHE B CE1 1 
ATOM   1260 C  CE2 . PHE B 1 23  ? -19.42690 -4.07607  43.27319 1.000 52.27891  ? 19  PHE B CE2 1 
ATOM   1261 C  CZ  . PHE B 1 23  ? -18.58516 -3.44177  44.16464 1.000 59.41241  ? 19  PHE B CZ  1 
ATOM   1262 N  N   . ASP B 1 24  ? -24.18669 0.02781   40.75674 1.000 38.79024  ? 20  ASP B N   1 
ATOM   1263 C  CA  . ASP B 1 24  ? -24.94295 1.11295   40.13336 1.000 44.36332  ? 20  ASP B CA  1 
ATOM   1264 C  C   . ASP B 1 24  ? -26.33796 1.11634   40.74527 1.000 48.02034  ? 20  ASP B C   1 
ATOM   1265 O  O   . ASP B 1 24  ? -27.23704 0.39986   40.30356 1.000 50.19656  ? 20  ASP B O   1 
ATOM   1266 C  CB  . ASP B 1 24  ? -24.98544 0.93813   38.62121 1.000 48.72102  ? 20  ASP B CB  1 
ATOM   1267 C  CG  . ASP B 1 24  ? -25.69803 2.07569   37.92579 1.000 47.27492  ? 20  ASP B CG  1 
ATOM   1268 O  OD1 . ASP B 1 24  ? -25.70141 3.19558   38.47520 1.000 46.88857  ? 20  ASP B OD1 1 
ATOM   1269 O  OD2 . ASP B 1 24  ? -26.25289 1.85044   36.82937 1.000 54.43147  ? 20  ASP B OD2 1 
ATOM   1270 N  N   . LYS B 1 25  ? -26.52308 1.94555   41.77506 1.000 49.83768  ? 21  LYS B N   1 
ATOM   1271 C  CA  . LYS B 1 25  ? -27.76267 1.90497   42.54567 1.000 45.80113  ? 21  LYS B CA  1 
ATOM   1272 C  C   . LYS B 1 25  ? -28.92823 2.50124   41.76359 1.000 49.31910  ? 21  LYS B C   1 
ATOM   1273 O  O   . LYS B 1 25  ? -30.01881 1.92036   41.72077 1.000 58.36240  ? 21  LYS B O   1 
ATOM   1274 C  CB  . LYS B 1 25  ? -27.57680 2.63199   43.87884 1.000 41.12694  ? 21  LYS B CB  1 
ATOM   1275 C  CG  . LYS B 1 25  ? -26.20903 2.42951   44.51417 1.000 44.19175  ? 21  LYS B CG  1 
ATOM   1276 C  CD  . LYS B 1 25  ? -25.98823 0.97781   44.91532 1.000 37.53706  ? 21  LYS B CD  1 
ATOM   1277 C  CE  . LYS B 1 25  ? -26.28007 0.75100   46.38974 1.000 34.11277  ? 21  LYS B CE  1 
ATOM   1278 N  NZ  . LYS B 1 25  ? -26.69497 -0.65466  46.66458 1.000 34.76500  ? 21  LYS B NZ  1 
ATOM   1279 N  N   . ASP B 1 26  ? -28.72399 3.66379   41.14187 1.000 46.28575  ? 22  ASP B N   1 
ATOM   1280 C  CA  . ASP B 1 26  ? -29.81540 4.32443   40.43578 1.000 44.88813  ? 22  ASP B CA  1 
ATOM   1281 C  C   . ASP B 1 26  ? -30.11154 3.70590   39.07553 1.000 54.48507  ? 22  ASP B C   1 
ATOM   1282 O  O   . ASP B 1 26  ? -31.13110 4.05062   38.46808 1.000 59.70199  ? 22  ASP B O   1 
ATOM   1283 C  CB  . ASP B 1 26  ? -29.51971 5.81971   40.27194 1.000 51.71559  ? 22  ASP B CB  1 
ATOM   1284 C  CG  . ASP B 1 26  ? -28.20309 6.08892   39.56521 1.000 45.86622  ? 22  ASP B CG  1 
ATOM   1285 O  OD1 . ASP B 1 26  ? -27.56701 5.13028   39.08210 1.000 49.35420  ? 22  ASP B OD1 1 
ATOM   1286 O  OD2 . ASP B 1 26  ? -27.80394 7.26972   39.49044 1.000 38.26393  ? 22  ASP B OD2 1 
ATOM   1287 N  N   . GLY B 1 27  ? -29.25655 2.81059   38.58580 1.000 47.96955  ? 23  GLY B N   1 
ATOM   1288 C  CA  . GLY B 1 27  ? -29.50079 2.17139   37.30823 1.000 50.85794  ? 23  GLY B CA  1 
ATOM   1289 C  C   . GLY B 1 27  ? -29.28722 3.05445   36.10198 1.000 49.87307  ? 23  GLY B C   1 
ATOM   1290 O  O   . GLY B 1 27  ? -29.86943 2.79441   35.04621 1.000 57.08130  ? 23  GLY B O   1 
ATOM   1291 N  N   . ASP B 1 28  ? -28.46658 4.09445   36.22476 1.000 45.23388  ? 24  ASP B N   1 
ATOM   1292 C  CA  . ASP B 1 28  ? -28.19827 5.00788   35.12285 1.000 48.15711  ? 24  ASP B CA  1 
ATOM   1293 C  C   . ASP B 1 28  ? -27.05662 4.54284   34.22679 1.000 52.30504  ? 24  ASP B C   1 
ATOM   1294 O  O   . ASP B 1 28  ? -26.72351 5.23860   33.26170 1.000 55.75034  ? 24  ASP B O   1 
ATOM   1295 C  CB  . ASP B 1 28  ? -27.90362 6.41321   35.66430 1.000 49.07486  ? 24  ASP B CB  1 
ATOM   1296 C  CG  . ASP B 1 28  ? -26.45489 6.59286   36.08154 1.000 50.40130  ? 24  ASP B CG  1 
ATOM   1297 O  OD1 . ASP B 1 28  ? -25.87080 5.64858   36.65522 1.000 48.19100  ? 24  ASP B OD1 1 
ATOM   1298 O  OD2 . ASP B 1 28  ? -25.89950 7.68461   35.83673 1.000 40.60277  ? 24  ASP B OD2 1 
ATOM   1299 N  N   . GLY B 1 29  ? -26.45110 3.39332   34.52045 1.000 54.93977  ? 25  GLY B N   1 
ATOM   1300 C  CA  . GLY B 1 29  ? -25.39785 2.84413   33.69400 1.000 52.36249  ? 25  GLY B CA  1 
ATOM   1301 C  C   . GLY B 1 29  ? -23.98949 3.24658   34.07394 1.000 55.75426  ? 25  GLY B C   1 
ATOM   1302 O  O   . GLY B 1 29  ? -23.03770 2.76410   33.44681 1.000 54.64907  ? 25  GLY B O   1 
ATOM   1303 N  N   . THR B 1 30  ? -23.81995 4.11248   35.07179 1.000 50.53650  ? 26  THR B N   1 
ATOM   1304 C  CA  . THR B 1 30  ? -22.50486 4.56810   35.50090 1.000 50.27735  ? 26  THR B CA  1 
ATOM   1305 C  C   . THR B 1 30  ? -22.36307 4.39042   37.00503 1.000 49.10970  ? 26  THR B C   1 
ATOM   1306 O  O   . THR B 1 30  ? -23.31772 4.60663   37.75670 1.000 46.35801  ? 26  THR B O   1 
ATOM   1307 C  CB  . THR B 1 30  ? -22.26763 6.04205   35.13757 1.000 43.55660  ? 26  THR B CB  1 
ATOM   1308 O  OG1 . THR B 1 30  ? -23.16411 6.87160   35.88736 1.000 50.20476  ? 26  THR B OG1 1 
ATOM   1309 C  CG2 . THR B 1 30  ? -22.48649 6.27637   33.64947 1.000 51.59399  ? 26  THR B CG2 1 
ATOM   1310 N  N   . ILE B 1 31  ? -21.16781 4.00084   37.43898 1.000 42.34571  ? 27  ILE B N   1 
ATOM   1311 C  CA  . ILE B 1 31  ? -20.84183 3.87995   38.85539 1.000 35.97327  ? 27  ILE B CA  1 
ATOM   1312 C  C   . ILE B 1 31  ? -20.00216 5.08639   39.25028 1.000 36.09833  ? 27  ILE B C   1 
ATOM   1313 O  O   . ILE B 1 31  ? -18.93545 5.32737   38.67209 1.000 34.92374  ? 27  ILE B O   1 
ATOM   1314 C  CB  . ILE B 1 31  ? -20.09888 2.56919   39.15785 1.000 35.15995  ? 27  ILE B CB  1 
ATOM   1315 C  CG1 . ILE B 1 31  ? -21.02572 1.36661   38.97379 1.000 37.96571  ? 27  ILE B CG1 1 
ATOM   1316 C  CG2 . ILE B 1 31  ? -19.53896 2.58916   40.57095 1.000 31.88351  ? 27  ILE B CG2 1 
ATOM   1317 C  CD1 . ILE B 1 31  ? -20.30866 0.11985   38.51121 1.000 39.43448  ? 27  ILE B CD1 1 
ATOM   1318 N  N   . THR B 1 32  ? -20.47900 5.84320   40.23130 1.000 31.08903  ? 28  THR B N   1 
ATOM   1319 C  CA  . THR B 1 32  ? -19.78307 7.02240   40.72173 1.000 32.89365  ? 28  THR B CA  1 
ATOM   1320 C  C   . THR B 1 32  ? -19.07133 6.71342   42.03548 1.000 25.79467  ? 28  THR B C   1 
ATOM   1321 O  O   . THR B 1 32  ? -19.28305 5.66970   42.65771 1.000 30.34500  ? 28  THR B O   1 
ATOM   1322 C  CB  . THR B 1 32  ? -20.76277 8.18618   40.90650 1.000 36.64496  ? 28  THR B CB  1 
ATOM   1323 O  OG1 . THR B 1 32  ? -21.71013 7.85622   41.93064 1.000 24.37784  ? 28  THR B OG1 1 
ATOM   1324 C  CG2 . THR B 1 32  ? -21.50406 8.46891   39.60764 1.000 28.16058  ? 28  THR B CG2 1 
ATOM   1325 N  N   . THR B 1 33  ? -18.20488 7.64475   42.44882 1.000 30.29077  ? 29  THR B N   1 
ATOM   1326 C  CA  . THR B 1 33  ? -17.53303 7.51279   43.73924 1.000 28.95277  ? 29  THR B CA  1 
ATOM   1327 C  C   . THR B 1 33  ? -18.54279 7.42015   44.87373 1.000 24.53475  ? 29  THR B C   1 
ATOM   1328 O  O   . THR B 1 33  ? -18.33846 6.67733   45.84144 1.000 23.21529  ? 29  THR B O   1 
ATOM   1329 C  CB  . THR B 1 33  ? -16.59243 8.69646   43.97802 1.000 36.73294  ? 29  THR B CB  1 
ATOM   1330 O  OG1 . THR B 1 33  ? -17.29672 9.92473   43.75083 1.000 25.47008  ? 29  THR B OG1 1 
ATOM   1331 C  CG2 . THR B 1 33  ? -15.37899 8.62837   43.06674 1.000 29.79004  ? 29  THR B CG2 1 
ATOM   1332 N  N   . LYS B 1 34  ? -19.63977 8.17334   44.76962 1.000 28.85237  ? 30  LYS B N   1 
ATOM   1333 C  CA  . LYS B 1 34  ? -20.65350 8.16665   45.81763 1.000 28.97147  ? 30  LYS B CA  1 
ATOM   1334 C  C   . LYS B 1 34  ? -21.30942 6.79751   45.93828 1.000 20.50867  ? 30  LYS B C   1 
ATOM   1335 O  O   . LYS B 1 34  ? -21.56566 6.31759   47.04865 1.000 24.02988  ? 30  LYS B O   1 
ATOM   1336 C  CB  . LYS B 1 34  ? -21.69588 9.24704   45.53039 1.000 22.18420  ? 30  LYS B CB  1 
ATOM   1337 C  CG  . LYS B 1 34  ? -21.25753 10.64621  45.93649 1.000 30.53842  ? 30  LYS B CG  1 
ATOM   1338 C  CD  . LYS B 1 34  ? -22.41328 11.63067  45.88775 1.000 24.89391  ? 30  LYS B CD  1 
ATOM   1339 C  CE  . LYS B 1 34  ? -22.71916 12.04191  44.45654 1.000 25.34086  ? 30  LYS B CE  1 
ATOM   1340 N  NZ  . LYS B 1 34  ? -21.56521 12.73414  43.81873 1.000 25.04487  ? 30  LYS B NZ  1 
ATOM   1341 N  N   . GLU B 1 35  ? -21.58149 6.14981   44.80418 1.000 23.31160  ? 31  GLU B N   1 
ATOM   1342 C  CA  . GLU B 1 35  ? -22.15678 4.81043   44.83820 1.000 29.55411  ? 31  GLU B CA  1 
ATOM   1343 C  C   . GLU B 1 35  ? -21.13017 3.77290   45.27084 1.000 27.74234  ? 31  GLU B C   1 
ATOM   1344 O  O   . GLU B 1 35  ? -21.48064 2.80263   45.95186 1.000 25.65461  ? 31  GLU B O   1 
ATOM   1345 C  CB  . GLU B 1 35  ? -22.73447 4.45652   43.46861 1.000 31.51858  ? 31  GLU B CB  1 
ATOM   1346 C  CG  . GLU B 1 35  ? -23.83368 5.39771   43.01319 1.000 29.61079  ? 31  GLU B CG  1 
ATOM   1347 C  CD  . GLU B 1 35  ? -24.42677 5.00079   41.67869 1.000 39.79993  ? 31  GLU B CD  1 
ATOM   1348 O  OE1 . GLU B 1 35  ? -23.67125 4.94616   40.68682 1.000 30.08528  ? 31  GLU B OE1 1 
ATOM   1349 O  OE2 . GLU B 1 35  ? -25.64863 4.74689   41.62126 1.000 38.64422  ? 31  GLU B OE2 1 
ATOM   1350 N  N   . LEU B 1 36  ? -19.86500 3.95964   44.89023 1.000 34.36025  ? 32  LEU B N   1 
ATOM   1351 C  CA  . LEU B 1 36  ? -18.81338 3.05603   45.34325 1.000 26.88841  ? 32  LEU B CA  1 
ATOM   1352 C  C   . LEU B 1 36  ? -18.66158 3.11927   46.85780 1.000 28.17464  ? 32  LEU B C   1 
ATOM   1353 O  O   . LEU B 1 36  ? -18.63895 2.08545   47.53506 1.000 23.11547  ? 32  LEU B O   1 
ATOM   1354 C  CB  . LEU B 1 36  ? -17.49527 3.39987   44.64758 1.000 28.11102  ? 32  LEU B CB  1 
ATOM   1355 C  CG  . LEU B 1 36  ? -16.56461 2.24006   44.29173 1.000 41.30429  ? 32  LEU B CG  1 
ATOM   1356 C  CD1 . LEU B 1 36  ? -17.21514 1.31951   43.27310 1.000 30.64388  ? 32  LEU B CD1 1 
ATOM   1357 C  CD2 . LEU B 1 36  ? -15.24300 2.76885   43.76209 1.000 41.02427  ? 32  LEU B CD2 1 
ATOM   1358 N  N   . GLY B 1 37  ? -18.57360 4.33242   47.40868 1.000 23.50137  ? 33  GLY B N   1 
ATOM   1359 C  CA  . GLY B 1 37  ? -18.44641 4.47208   48.85058 1.000 25.97608  ? 33  GLY B CA  1 
ATOM   1360 C  C   . GLY B 1 37  ? -19.63536 3.90686   49.60296 1.000 29.75024  ? 33  GLY B C   1 
ATOM   1361 O  O   . GLY B 1 37  ? -19.48310 3.34583   50.69080 1.000 32.98949  ? 33  GLY B O   1 
ATOM   1362 N  N   . THR B 1 38  ? -20.83676 4.04722   49.03549 1.000 28.54214  ? 34  THR B N   1 
ATOM   1363 C  CA  . THR B 1 38  ? -22.02482 3.48019   49.66636 1.000 21.83085  ? 34  THR B CA  1 
ATOM   1364 C  C   . THR B 1 38  ? -21.93485 1.96056   49.74293 1.000 26.18027  ? 34  THR B C   1 
ATOM   1365 O  O   . THR B 1 38  ? -22.25902 1.36152   50.77568 1.000 27.91867  ? 34  THR B O   1 
ATOM   1366 C  CB  . THR B 1 38  ? -23.28000 3.90643   48.90121 1.000 30.95032  ? 34  THR B CB  1 
ATOM   1367 O  OG1 . THR B 1 38  ? -23.59256 5.27104   49.21014 1.000 32.26859  ? 34  THR B OG1 1 
ATOM   1368 C  CG2 . THR B 1 38  ? -24.46462 3.02021   49.26499 1.000 23.12812  ? 34  THR B CG2 1 
ATOM   1369 N  N   . VAL B 1 39  ? -21.48599 1.32110   48.66177 1.000 26.14944  ? 35  VAL B N   1 
ATOM   1370 C  CA  . VAL B 1 39  ? -21.36339 -0.13371  48.65262 1.000 29.44663  ? 35  VAL B CA  1 
ATOM   1371 C  C   . VAL B 1 39  ? -20.25443 -0.58311  49.59748 1.000 26.34851  ? 35  VAL B C   1 
ATOM   1372 O  O   . VAL B 1 39  ? -20.42554 -1.53179  50.37251 1.000 28.50398  ? 35  VAL B O   1 
ATOM   1373 C  CB  . VAL B 1 39  ? -21.12784 -0.64304  47.21906 1.000 31.28584  ? 35  VAL B CB  1 
ATOM   1374 C  CG1 . VAL B 1 39  ? -20.85623 -2.14064  47.22309 1.000 23.45625  ? 35  VAL B CG1 1 
ATOM   1375 C  CG2 . VAL B 1 39  ? -22.32677 -0.32045  46.34057 1.000 27.76027  ? 35  VAL B CG2 1 
HETATM 1376 N  N   . MSE B 1 40  ? -19.10565 0.08846   49.54971 1.000 29.39476  ? 36  MSE B N   1 
HETATM 1377 C  CA  . MSE B 1 40  ? -17.97401 -0.26398  50.40560 1.000 26.36361  ? 36  MSE B CA  1 
HETATM 1378 C  C   . MSE B 1 40  ? -18.31468 -0.13190  51.88593 1.000 26.56175  ? 36  MSE B C   1 
HETATM 1379 O  O   . MSE B 1 40  ? -17.92786 -0.97442  52.69515 1.000 30.87551  ? 36  MSE B O   1 
HETATM 1380 C  CB  . MSE B 1 40  ? -16.75371 0.60128   50.07347 1.000 24.99406  ? 36  MSE B CB  1 
HETATM 1381 C  CG  . MSE B 1 40  ? -16.23911 0.42547   48.65582 1.000 24.69476  ? 36  MSE B CG  1 
HETATM 1382 SE SE  . MSE B 1 40  ? -15.87747 -1.44150  48.22272 1.000 62.48298  ? 36  MSE B SE  1 
HETATM 1383 C  CE  . MSE B 1 40  ? -14.44402 -1.18477  46.92865 1.000 34.15127  ? 36  MSE B CE  1 
ATOM   1384 N  N   . ARG B 1 41  ? -19.04201 0.92989   52.23858 1.000 20.59660  ? 37  ARG B N   1 
ATOM   1385 C  CA  . ARG B 1 41  ? -19.43737 1.10780   53.63147 1.000 30.32240  ? 37  ARG B CA  1 
ATOM   1386 C  C   . ARG B 1 41  ? -20.50012 0.09930   54.04748 1.000 32.11364  ? 37  ARG B C   1 
ATOM   1387 O  O   . ARG B 1 41  ? -20.50922 -0.34642  55.20059 1.000 33.17190  ? 37  ARG B O   1 
ATOM   1388 C  CB  . ARG B 1 41  ? -19.92801 2.53534   53.86639 1.000 29.04594  ? 37  ARG B CB  1 
ATOM   1389 C  CG  . ARG B 1 41  ? -18.81881 3.57723   53.83299 1.000 21.84797  ? 37  ARG B CG  1 
ATOM   1390 C  CD  . ARG B 1 41  ? -19.31619 4.92099   54.34139 1.000 22.05809  ? 37  ARG B CD  1 
ATOM   1391 N  NE  . ARG B 1 41  ? -20.27674 5.52311   53.42522 1.000 16.29412  ? 37  ARG B NE  1 
ATOM   1392 C  CZ  . ARG B 1 41  ? -19.94942 6.16087   52.30962 1.000 26.13929  ? 37  ARG B CZ  1 
ATOM   1393 N  NH1 . ARG B 1 41  ? -18.68660 6.31118   51.94402 1.000 19.86079  ? 37  ARG B NH1 1 
ATOM   1394 N  NH2 . ARG B 1 41  ? -20.91338 6.66071   51.54118 1.000 24.18952  ? 37  ARG B NH2 1 
ATOM   1395 N  N   . SER B 1 42  ? -21.39741 -0.27600  53.13251 1.000 27.33491  ? 38  SER B N   1 
ATOM   1396 C  CA  . SER B 1 42  ? -22.32875 -1.36118  53.41544 1.000 30.69059  ? 38  SER B CA  1 
ATOM   1397 C  C   . SER B 1 42  ? -21.61960 -2.69812  53.57597 1.000 30.21145  ? 38  SER B C   1 
ATOM   1398 O  O   . SER B 1 42  ? -22.23839 -3.65855  54.04797 1.000 32.68777  ? 38  SER B O   1 
ATOM   1399 C  CB  . SER B 1 42  ? -23.38204 -1.45897  52.30882 1.000 25.95728  ? 38  SER B CB  1 
ATOM   1400 O  OG  . SER B 1 42  ? -22.79823 -1.84695  51.07790 1.000 26.88340  ? 38  SER B OG  1 
ATOM   1401 N  N   . LEU B 1 43  ? -20.34333 -2.78004  53.19665 1.000 30.06225  ? 39  LEU B N   1 
ATOM   1402 C  CA  . LEU B 1 43  ? -19.53091 -3.97592  53.37133 1.000 37.28515  ? 39  LEU B CA  1 
ATOM   1403 C  C   . LEU B 1 43  ? -18.52961 -3.82916  54.51274 1.000 34.54883  ? 39  LEU B C   1 
ATOM   1404 O  O   . LEU B 1 43  ? -17.53797 -4.56351  54.56226 1.000 36.94168  ? 39  LEU B O   1 
ATOM   1405 C  CB  . LEU B 1 43  ? -18.80784 -4.31402  52.06779 1.000 36.57666  ? 39  LEU B CB  1 
ATOM   1406 C  CG  . LEU B 1 43  ? -19.69463 -4.86643  50.95080 1.000 43.40802  ? 39  LEU B CG  1 
ATOM   1407 C  CD1 . LEU B 1 43  ? -18.88228 -5.11264  49.69140 1.000 34.01465  ? 39  LEU B CD1 1 
ATOM   1408 C  CD2 . LEU B 1 43  ? -20.38141 -6.14406  51.40655 1.000 35.92001  ? 39  LEU B CD2 1 
ATOM   1409 N  N   . GLY B 1 44  ? -18.76501 -2.88832  55.42614 1.000 30.78001  ? 40  GLY B N   1 
ATOM   1410 C  CA  . GLY B 1 44  ? -17.92092 -2.71636  56.58958 1.000 34.72975  ? 40  GLY B CA  1 
ATOM   1411 C  C   . GLY B 1 44  ? -16.66106 -1.90748  56.37440 1.000 33.36915  ? 40  GLY B C   1 
ATOM   1412 O  O   . GLY B 1 44  ? -15.94509 -1.64242  57.34851 1.000 42.30152  ? 40  GLY B O   1 
ATOM   1413 N  N   . GLN B 1 45  ? -16.36219 -1.50727  55.14355 1.000 29.97934  ? 41  GLN B N   1 
ATOM   1414 C  CA  . GLN B 1 45  ? -15.16238 -0.73707  54.85708 1.000 36.16785  ? 41  GLN B CA  1 
ATOM   1415 C  C   . GLN B 1 45  ? -15.45560 0.75986   54.94113 1.000 42.49111  ? 41  GLN B C   1 
ATOM   1416 O  O   . GLN B 1 45  ? -16.59729 1.18781   55.11910 1.000 28.98445  ? 41  GLN B O   1 
ATOM   1417 C  CB  . GLN B 1 45  ? -14.61200 -1.10440  53.47928 1.000 36.90546  ? 41  GLN B CB  1 
ATOM   1418 C  CG  . GLN B 1 45  ? -14.79490 -2.57027  53.11118 1.000 31.08410  ? 41  GLN B CG  1 
ATOM   1419 C  CD  . GLN B 1 45  ? -14.03795 -3.50579  54.03532 1.000 35.46265  ? 41  GLN B CD  1 
ATOM   1420 O  OE1 . GLN B 1 45  ? -12.83323 -3.70357  53.88268 1.000 37.86917  ? 41  GLN B OE1 1 
ATOM   1421 N  NE2 . GLN B 1 45  ? -14.74451 -4.09308  54.99568 1.000 25.76321  ? 41  GLN B NE2 1 
ATOM   1422 N  N   . ASN B 1 46  ? -14.40170 1.56414   54.81336 1.000 30.37899  ? 42  ASN B N   1 
ATOM   1423 C  CA  . ASN B 1 46  ? -14.52473 3.02137   54.88142 1.000 39.16124  ? 42  ASN B CA  1 
ATOM   1424 C  C   . ASN B 1 46  ? -13.40225 3.67234   54.08691 1.000 37.22162  ? 42  ASN B C   1 
ATOM   1425 O  O   . ASN B 1 46  ? -12.41593 4.16008   54.64969 1.000 36.84042  ? 42  ASN B O   1 
ATOM   1426 C  CB  . ASN B 1 46  ? -14.51109 3.50829   56.33064 1.000 38.63650  ? 42  ASN B CB  1 
ATOM   1427 C  CG  . ASN B 1 46  ? -15.59664 4.52684   56.61000 1.000 43.16895  ? 42  ASN B CG  1 
ATOM   1428 O  OD1 . ASN B 1 46  ? -15.77670 5.48120   55.85326 1.000 37.46636  ? 42  ASN B OD1 1 
ATOM   1429 N  ND2 . ASN B 1 46  ? -16.32694 4.33035   57.70135 1.000 39.55295  ? 42  ASN B ND2 1 
ATOM   1430 N  N   . PRO B 1 47  ? -13.52456 3.70042   52.76343 1.000 31.27967  ? 43  PRO B N   1 
ATOM   1431 C  CA  . PRO B 1 47  ? -12.53688 4.41032   51.94589 1.000 30.30770  ? 43  PRO B CA  1 
ATOM   1432 C  C   . PRO B 1 47  ? -12.77028 5.91420   51.95685 1.000 37.27130  ? 43  PRO B C   1 
ATOM   1433 O  O   . PRO B 1 47  ? -13.87206 6.40248   52.21208 1.000 34.05997  ? 43  PRO B O   1 
ATOM   1434 C  CB  . PRO B 1 47  ? -12.76637 3.82731   50.54783 1.000 30.63125  ? 43  PRO B CB  1 
ATOM   1435 C  CG  . PRO B 1 47  ? -14.22226 3.49463   50.54867 1.000 31.16704  ? 43  PRO B CG  1 
ATOM   1436 C  CD  . PRO B 1 47  ? -14.48825 2.95888   51.93172 1.000 31.32040  ? 43  PRO B CD  1 
ATOM   1437 N  N   . THR B 1 48  ? -11.69679 6.64871   51.67022 1.000 30.90748  ? 44  THR B N   1 
ATOM   1438 C  CA  . THR B 1 48  ? -11.75163 8.10027   51.61199 1.000 38.06788  ? 44  THR B CA  1 
ATOM   1439 C  C   . THR B 1 48  ? -12.17254 8.55529   50.21489 1.000 36.76726  ? 44  THR B C   1 
ATOM   1440 O  O   . THR B 1 48  ? -12.33747 7.75255   49.29354 1.000 30.80018  ? 44  THR B O   1 
ATOM   1441 C  CB  . THR B 1 48  ? -10.40265 8.70649   51.99794 1.000 34.03571  ? 44  THR B CB  1 
ATOM   1442 O  OG1 . THR B 1 48  ? -9.44710  8.45155   50.96120 1.000 39.68092  ? 44  THR B OG1 1 
ATOM   1443 C  CG2 . THR B 1 48  ? -9.90143  8.10502   53.30302 1.000 38.27825  ? 44  THR B CG2 1 
ATOM   1444 N  N   . GLU B 1 49  ? -12.34451 9.86989   50.05251 1.000 33.37914  ? 45  GLU B N   1 
ATOM   1445 C  CA  . GLU B 1 49  ? -12.75623 10.40270  48.75774 1.000 33.72764  ? 45  GLU B CA  1 
ATOM   1446 C  C   . GLU B 1 49  ? -11.67016 10.20322  47.70654 1.000 38.70172  ? 45  GLU B C   1 
ATOM   1447 O  O   . GLU B 1 49  ? -11.97180 9.89744   46.54765 1.000 38.67473  ? 45  GLU B O   1 
ATOM   1448 C  CB  . GLU B 1 49  ? -13.13058 11.88312  48.88867 1.000 34.10104  ? 45  GLU B CB  1 
ATOM   1449 C  CG  . GLU B 1 49  ? -11.96189 12.84103  49.10407 1.000 36.71153  ? 45  GLU B CG  1 
ATOM   1450 C  CD  . GLU B 1 49  ? -11.32741 12.69784  50.47291 1.000 38.19622  ? 45  GLU B CD  1 
ATOM   1451 O  OE1 . GLU B 1 49  ? -11.98174 13.05331  51.47616 1.000 33.72207  ? 45  GLU B OE1 1 
ATOM   1452 O  OE2 . GLU B 1 49  ? -10.17282 12.22540  50.54671 1.000 46.84554  ? 45  GLU B OE2 1 
ATOM   1453 N  N   . ALA B 1 50  ? -10.40070 10.35155  48.09309 1.000 37.81291  ? 46  ALA B N   1 
ATOM   1454 C  CA  . ALA B 1 50  ? -9.31642  10.17312  47.13389 1.000 39.21007  ? 46  ALA B CA  1 
ATOM   1455 C  C   . ALA B 1 50  ? -9.11078  8.70017   46.80719 1.000 34.04098  ? 46  ALA B C   1 
ATOM   1456 O  O   . ALA B 1 50  ? -8.81373  8.34846   45.65953 1.000 34.36230  ? 46  ALA B O   1 
ATOM   1457 C  CB  . ALA B 1 50  ? -8.02862  10.79421  47.67358 1.000 38.33207  ? 46  ALA B CB  1 
ATOM   1458 N  N   . GLU B 1 51  ? -9.26403  7.82495   47.80388 1.000 34.72999  ? 47  GLU B N   1 
ATOM   1459 C  CA  . GLU B 1 51  ? -9.18579  6.39132   47.54541 1.000 38.76986  ? 47  GLU B CA  1 
ATOM   1460 C  C   . GLU B 1 51  ? -10.31528 5.94214   46.62712 1.000 40.22413  ? 47  GLU B C   1 
ATOM   1461 O  O   . GLU B 1 51  ? -10.11745 5.08482   45.75804 1.000 31.67724  ? 47  GLU B O   1 
ATOM   1462 C  CB  . GLU B 1 51  ? -9.21948  5.61967   48.86493 1.000 38.65346  ? 47  GLU B CB  1 
ATOM   1463 C  CG  . GLU B 1 51  ? -7.93421  5.71987   49.67395 1.000 36.57845  ? 47  GLU B CG  1 
ATOM   1464 C  CD  . GLU B 1 51  ? -8.08896  5.18961   51.08607 1.000 31.62990  ? 47  GLU B CD  1 
ATOM   1465 O  OE1 . GLU B 1 51  ? -9.20569  5.27974   51.63712 1.000 40.40204  ? 47  GLU B OE1 1 
ATOM   1466 O  OE2 . GLU B 1 51  ? -7.09363  4.68428   51.64646 1.000 48.05812  ? 47  GLU B OE2 1 
ATOM   1467 N  N   . LEU B 1 52  ? -11.50822 6.51664   46.80297 1.000 35.66085  ? 48  LEU B N   1 
ATOM   1468 C  CA  . LEU B 1 52  ? -12.61472 6.22839   45.89620 1.000 32.38881  ? 48  LEU B CA  1 
ATOM   1469 C  C   . LEU B 1 52  ? -12.34687 6.78958   44.50593 1.000 34.56508  ? 48  LEU B C   1 
ATOM   1470 O  O   . LEU B 1 52  ? -12.64420 6.13651   43.49872 1.000 35.07892  ? 48  LEU B O   1 
ATOM   1471 C  CB  . LEU B 1 52  ? -13.91491 6.79332   46.46574 1.000 25.33719  ? 48  LEU B CB  1 
ATOM   1472 C  CG  . LEU B 1 52  ? -14.50684 6.02975   47.65063 1.000 33.93043  ? 48  LEU B CG  1 
ATOM   1473 C  CD1 . LEU B 1 52  ? -15.67039 6.79750   48.24716 1.000 31.86967  ? 48  LEU B CD1 1 
ATOM   1474 C  CD2 . LEU B 1 52  ? -14.95735 4.64782   47.20434 1.000 28.70972  ? 48  LEU B CD2 1 
ATOM   1475 N  N   . GLN B 1 53  ? -11.78936 8.00139   44.43136 1.000 38.65816  ? 49  GLN B N   1 
ATOM   1476 C  CA  . GLN B 1 53  ? -11.40115 8.55946   43.14076 1.000 35.09302  ? 49  GLN B CA  1 
ATOM   1477 C  C   . GLN B 1 53  ? -10.28237 7.74950   42.50030 1.000 42.90783  ? 49  GLN B C   1 
ATOM   1478 O  O   . GLN B 1 53  ? -10.23297 7.62120   41.27179 1.000 43.43591  ? 49  GLN B O   1 
ATOM   1479 C  CB  . GLN B 1 53  ? -10.97142 10.01711  43.30796 1.000 41.15154  ? 49  GLN B CB  1 
ATOM   1480 C  CG  . GLN B 1 53  ? -12.11179 10.97814  43.60263 1.000 39.44365  ? 49  GLN B CG  1 
ATOM   1481 C  CD  . GLN B 1 53  ? -11.69422 12.42952  43.48376 1.000 44.73163  ? 49  GLN B CD  1 
ATOM   1482 O  OE1 . GLN B 1 53  ? -10.66524 12.83471  44.02389 1.000 43.35219  ? 49  GLN B OE1 1 
ATOM   1483 N  NE2 . GLN B 1 53  ? -12.49545 13.22309  42.78176 1.000 41.00646  ? 49  GLN B NE2 1 
ATOM   1484 N  N   . ASP B 1 54  ? -9.37937  7.19566   43.31374 1.000 42.07237  ? 50  ASP B N   1 
ATOM   1485 C  CA  . ASP B 1 54  ? -8.29437  6.38112   42.77685 1.000 42.00571  ? 50  ASP B CA  1 
ATOM   1486 C  C   . ASP B 1 54  ? -8.82509  5.09871   42.15072 1.000 45.98354  ? 50  ASP B C   1 
ATOM   1487 O  O   . ASP B 1 54  ? -8.34794  4.67494   41.09131 1.000 44.46152  ? 50  ASP B O   1 
ATOM   1488 C  CB  . ASP B 1 54  ? -7.28814  6.05749   43.88037 1.000 35.07681  ? 50  ASP B CB  1 
ATOM   1489 C  CG  . ASP B 1 54  ? -6.24961  7.14255   44.05620 1.000 47.64696  ? 50  ASP B CG  1 
ATOM   1490 O  OD1 . ASP B 1 54  ? -5.96820  7.86291   43.07454 1.000 50.96223  ? 50  ASP B OD1 1 
ATOM   1491 O  OD2 . ASP B 1 54  ? -5.71418  7.27620   45.17541 1.000 46.57094  ? 50  ASP B OD2 1 
HETATM 1492 N  N   . MSE B 1 55  ? -9.80782  4.47150   42.79116 1.000 43.31117  ? 51  MSE B N   1 
HETATM 1493 C  CA  . MSE B 1 55  ? -10.39717 3.23084   42.30279 1.000 46.39776  ? 51  MSE B CA  1 
HETATM 1494 C  C   . MSE B 1 55  ? -10.95641 3.39288   40.89755 1.000 46.28185  ? 51  MSE B C   1 
HETATM 1495 O  O   . MSE B 1 55  ? -10.75146 2.53916   40.03612 1.000 42.49642  ? 51  MSE B O   1 
HETATM 1496 C  CB  . MSE B 1 55  ? -11.50165 2.76082   43.24938 1.000 42.88989  ? 51  MSE B CB  1 
HETATM 1497 C  CG  . MSE B 1 55  ? -11.00011 2.02240   44.47535 1.000 51.03218  ? 51  MSE B CG  1 
HETATM 1498 SE SE  . MSE B 1 55  ? -12.44932 1.51763   45.67621 1.000 77.32214  ? 51  MSE B SE  1 
HETATM 1499 C  CE  . MSE B 1 55  ? -11.90402 2.52636   47.25067 1.000 50.46355  ? 51  MSE B CE  1 
ATOM   1500 N  N   . ILE B 1 56  ? -11.66532 4.49993   40.67294 1.000 45.14536  ? 52  ILE B N   1 
ATOM   1501 C  CA  . ILE B 1 56  ? -12.25822 4.74149   39.36237 1.000 41.64599  ? 52  ILE B CA  1 
ATOM   1502 C  C   . ILE B 1 56  ? -11.18364 5.10555   38.34519 1.000 52.93036  ? 52  ILE B C   1 
ATOM   1503 O  O   . ILE B 1 56  ? -11.25112 4.69927   37.17872 1.000 46.78968  ? 52  ILE B O   1 
ATOM   1504 C  CB  . ILE B 1 56  ? -13.34762 5.82606   39.46279 1.000 39.96431  ? 52  ILE B CB  1 
ATOM   1505 C  CG1 . ILE B 1 56  ? -14.57461 5.27655   40.19261 1.000 38.06559  ? 52  ILE B CG1 1 
ATOM   1506 C  CG2 . ILE B 1 56  ? -13.73259 6.35152   38.08906 1.000 40.97194  ? 52  ILE B CG2 1 
ATOM   1507 C  CD1 . ILE B 1 56  ? -15.64336 6.30343   40.44088 1.000 45.13633  ? 52  ILE B CD1 1 
ATOM   1508 N  N   . ASN B 1 57  ? -10.16265 5.85165   38.77302 1.000 43.98602  ? 53  ASN B N   1 
ATOM   1509 C  CA  . ASN B 1 57  ? -9.14980  6.32678   37.83612 1.000 50.97566  ? 53  ASN B CA  1 
ATOM   1510 C  C   . ASN B 1 57  ? -8.29417  5.19086   37.28745 1.000 47.30096  ? 53  ASN B C   1 
ATOM   1511 O  O   . ASN B 1 57  ? -7.78138  5.29255   36.16698 1.000 46.29273  ? 53  ASN B O   1 
ATOM   1512 C  CB  . ASN B 1 57  ? -8.26565  7.37475   38.50917 1.000 50.12532  ? 53  ASN B CB  1 
ATOM   1513 C  CG  . ASN B 1 57  ? -7.67159  8.35257   37.51978 1.000 53.05467  ? 53  ASN B CG  1 
ATOM   1514 O  OD1 . ASN B 1 57  ? -8.39155  9.11350   36.87269 1.000 56.87707  ? 53  ASN B OD1 1 
ATOM   1515 N  ND2 . ASN B 1 57  ? -6.35070  8.33454   37.39180 1.000 54.27811  ? 53  ASN B ND2 1 
ATOM   1516 N  N   . GLU B 1 58  ? -8.12905  4.10686   38.04974 1.000 43.20324  ? 54  GLU B N   1 
ATOM   1517 C  CA  . GLU B 1 58  ? -7.29723  2.99892   37.59224 1.000 51.97223  ? 54  GLU B CA  1 
ATOM   1518 C  C   . GLU B 1 58  ? -7.88487  2.29593   36.37420 1.000 52.12130  ? 54  GLU B C   1 
ATOM   1519 O  O   . GLU B 1 58  ? -7.16573  1.55376   35.69591 1.000 57.43859  ? 54  GLU B O   1 
ATOM   1520 C  CB  . GLU B 1 58  ? -7.09005  1.99250   38.72647 1.000 53.26147  ? 54  GLU B CB  1 
ATOM   1521 C  CG  . GLU B 1 58  ? -5.97436  2.36624   39.69412 1.000 62.90255  ? 54  GLU B CG  1 
ATOM   1522 C  CD  . GLU B 1 58  ? -4.76033  1.46314   39.57175 1.000 62.19275  ? 54  GLU B CD  1 
ATOM   1523 O  OE1 . GLU B 1 58  ? -4.07486  1.51717   38.52842 1.000 63.83834  ? 54  GLU B OE1 1 
ATOM   1524 O  OE2 . GLU B 1 58  ? -4.48981  0.69881   40.52186 1.000 67.62630  ? 54  GLU B OE2 1 
ATOM   1525 N  N   . VAL B 1 59  ? -9.16859  2.50840   36.08066 1.000 48.60637  ? 55  VAL B N   1 
ATOM   1526 C  CA  . VAL B 1 59  ? -9.82160  1.89193   34.93253 1.000 47.18234  ? 55  VAL B CA  1 
ATOM   1527 C  C   . VAL B 1 59  ? -10.57705 2.89206   34.07527 1.000 47.50892  ? 55  VAL B C   1 
ATOM   1528 O  O   . VAL B 1 59  ? -11.20143 2.49754   33.08947 1.000 47.73150  ? 55  VAL B O   1 
ATOM   1529 C  CB  . VAL B 1 59  ? -10.76767 0.75276   35.37058 1.000 47.70088  ? 55  VAL B CB  1 
ATOM   1530 C  CG1 . VAL B 1 59  ? -9.99366  -0.34779  36.08164 1.000 50.71817  ? 55  VAL B CG1 1 
ATOM   1531 C  CG2 . VAL B 1 59  ? -11.87379 1.29702   36.26137 1.000 45.95383  ? 55  VAL B CG2 1 
ATOM   1532 N  N   . ASP B 1 60  ? -10.54497 4.18051   34.41181 1.000 52.24056  ? 56  ASP B N   1 
ATOM   1533 C  CA  . ASP B 1 60  ? -11.31157 5.19225   33.68731 1.000 53.63283  ? 56  ASP B CA  1 
ATOM   1534 C  C   . ASP B 1 60  ? -10.60522 5.49873   32.37296 1.000 54.56857  ? 56  ASP B C   1 
ATOM   1535 O  O   . ASP B 1 60  ? -9.62353  6.24315   32.33737 1.000 47.83367  ? 56  ASP B O   1 
ATOM   1536 C  CB  . ASP B 1 60  ? -11.47755 6.44692   34.53594 1.000 49.74528  ? 56  ASP B CB  1 
ATOM   1537 C  CG  . ASP B 1 60  ? -12.61291 7.32479   34.05717 1.000 50.00456  ? 56  ASP B CG  1 
ATOM   1538 O  OD1 . ASP B 1 60  ? -13.48047 6.81843   33.31529 1.000 44.44614  ? 56  ASP B OD1 1 
ATOM   1539 O  OD2 . ASP B 1 60  ? -12.64410 8.51570   34.43050 1.000 49.33592  ? 56  ASP B OD2 1 
ATOM   1540 N  N   . ALA B 1 61  ? -11.11266 4.92680   31.28038 1.000 51.53096  ? 57  ALA B N   1 
ATOM   1541 C  CA  . ALA B 1 61  ? -10.48543 5.12306   29.97731 1.000 53.92722  ? 57  ALA B CA  1 
ATOM   1542 C  C   . ALA B 1 61  ? -10.79805 6.50628   29.41780 1.000 54.06613  ? 57  ALA B C   1 
ATOM   1543 O  O   . ALA B 1 61  ? -9.88954  7.29361   29.13047 1.000 53.45214  ? 57  ALA B O   1 
ATOM   1544 C  CB  . ALA B 1 61  ? -10.93730 4.02933   29.00656 1.000 48.68398  ? 57  ALA B CB  1 
ATOM   1545 N  N   . ASP B 1 62  ? -12.08249 6.82280   29.25751 1.000 53.10104  ? 58  ASP B N   1 
ATOM   1546 C  CA  . ASP B 1 62  ? -12.48885 8.09672   28.67613 1.000 47.28762  ? 58  ASP B CA  1 
ATOM   1547 C  C   . ASP B 1 62  ? -12.33381 9.27243   29.63372 1.000 54.54829  ? 58  ASP B C   1 
ATOM   1548 O  O   . ASP B 1 62  ? -12.57236 10.41438  29.22593 1.000 50.54119  ? 58  ASP B O   1 
ATOM   1549 C  CB  . ASP B 1 62  ? -13.93686 8.01148   28.18455 1.000 53.45702  ? 58  ASP B CB  1 
ATOM   1550 C  CG  . ASP B 1 62  ? -14.89328 7.54043   29.26077 1.000 51.67568  ? 58  ASP B CG  1 
ATOM   1551 O  OD1 . ASP B 1 62  ? -14.42688 7.20315   30.36892 1.000 55.16322  ? 58  ASP B OD1 1 
ATOM   1552 O  OD2 . ASP B 1 62  ? -16.11352 7.50394   28.99669 1.000 52.43956  ? 58  ASP B OD2 1 
ATOM   1553 N  N   . GLY B 1 63  ? -11.94922 9.02734   30.88380 1.000 58.08378  ? 59  GLY B N   1 
ATOM   1554 C  CA  . GLY B 1 63  ? -11.67060 10.10930  31.80995 1.000 55.91012  ? 59  GLY B CA  1 
ATOM   1555 C  C   . GLY B 1 63  ? -12.86697 10.94342  32.20860 1.000 58.25037  ? 59  GLY B C   1 
ATOM   1556 O  O   . GLY B 1 63  ? -12.70991 12.13084  32.50947 1.000 52.33461  ? 59  GLY B O   1 
ATOM   1557 N  N   . ASN B 1 64  ? -14.06184 10.35797  32.22283 1.000 53.04394  ? 60  ASN B N   1 
ATOM   1558 C  CA  . ASN B 1 64  ? -15.26359 11.07930  32.61979 1.000 47.46433  ? 60  ASN B CA  1 
ATOM   1559 C  C   . ASN B 1 64  ? -15.55980 10.96581  34.10986 1.000 46.37784  ? 60  ASN B C   1 
ATOM   1560 O  O   . ASN B 1 64  ? -16.59951 11.45900  34.55872 1.000 52.02007  ? 60  ASN B O   1 
ATOM   1561 C  CB  . ASN B 1 64  ? -16.47067 10.58654  31.81278 1.000 49.82521  ? 60  ASN B CB  1 
ATOM   1562 C  CG  . ASN B 1 64  ? -16.75239 9.11181   32.02233 1.000 46.61827  ? 60  ASN B CG  1 
ATOM   1563 O  OD1 . ASN B 1 64  ? -15.95442 8.39333   32.62470 1.000 49.27690  ? 60  ASN B OD1 1 
ATOM   1564 N  ND2 . ASN B 1 64  ? -17.89421 8.65274   31.52501 1.000 39.34514  ? 60  ASN B ND2 1 
ATOM   1565 N  N   . GLY B 1 65  ? -14.68004 10.33080  34.88190 1.000 48.20715  ? 61  GLY B N   1 
ATOM   1566 C  CA  . GLY B 1 65  ? -14.86260 10.20371  36.31164 1.000 48.55115  ? 61  GLY B CA  1 
ATOM   1567 C  C   . GLY B 1 65  ? -15.84929 9.14490   36.75048 1.000 49.83912  ? 61  GLY B C   1 
ATOM   1568 O  O   . GLY B 1 65  ? -16.03814 8.96562   37.96053 1.000 45.82388  ? 61  GLY B O   1 
ATOM   1569 N  N   . THR B 1 66  ? -16.48481 8.43925   35.81682 1.000 41.55803  ? 62  THR B N   1 
ATOM   1570 C  CA  . THR B 1 66  ? -17.45972 7.40706   36.13672 1.000 41.51222  ? 62  THR B CA  1 
ATOM   1571 C  C   . THR B 1 66  ? -17.08042 6.11250   35.43430 1.000 42.00796  ? 62  THR B C   1 
ATOM   1572 O  O   . THR B 1 66  ? -16.59270 6.13095   34.30048 1.000 45.03066  ? 62  THR B O   1 
ATOM   1573 C  CB  . THR B 1 66  ? -18.87906 7.82488   35.72376 1.000 52.72245  ? 62  THR B CB  1 
ATOM   1574 O  OG1 . THR B 1 66  ? -18.90421 8.12293   34.32204 1.000 59.22018  ? 62  THR B OG1 1 
ATOM   1575 C  CG2 . THR B 1 66  ? -19.32649 9.05058   36.50654 1.000 44.64651  ? 62  THR B CG2 1 
ATOM   1576 N  N   . ILE B 1 67  ? -17.30893 4.99224   36.11171 1.000 43.89149  ? 63  ILE B N   1 
ATOM   1577 C  CA  . ILE B 1 67  ? -17.01201 3.67332   35.56383 1.000 40.60276  ? 63  ILE B CA  1 
ATOM   1578 C  C   . ILE B 1 67  ? -18.24596 3.16667   34.82810 1.000 46.33678  ? 63  ILE B C   1 
ATOM   1579 O  O   . ILE B 1 67  ? -19.31761 3.01977   35.42565 1.000 39.39163  ? 63  ILE B O   1 
ATOM   1580 C  CB  . ILE B 1 67  ? -16.59057 2.69234   36.66862 1.000 40.72781  ? 63  ILE B CB  1 
ATOM   1581 C  CG1 . ILE B 1 67  ? -15.20747 3.04965   37.21441 1.000 47.26101  ? 63  ILE B CG1 1 
ATOM   1582 C  CG2 . ILE B 1 67  ? -16.59955 1.26524   36.14745 1.000 46.29410  ? 63  ILE B CG2 1 
ATOM   1583 C  CD1 . ILE B 1 67  ? -14.78437 2.19340   38.39212 1.000 46.87686  ? 63  ILE B CD1 1 
ATOM   1584 N  N   . ASP B 1 68  ? -18.10050 2.90107   33.53258 1.000 47.64780  ? 64  ASP B N   1 
ATOM   1585 C  CA  . ASP B 1 68  ? -19.18579 2.33146   32.74966 1.000 46.94825  ? 64  ASP B CA  1 
ATOM   1586 C  C   . ASP B 1 68  ? -19.04802 0.80928   32.72813 1.000 42.58733  ? 64  ASP B C   1 
ATOM   1587 O  O   . ASP B 1 68  ? -18.24699 0.22822   33.46625 1.000 41.41205  ? 64  ASP B O   1 
ATOM   1588 C  CB  . ASP B 1 68  ? -19.22090 2.95694   31.35274 1.000 40.83554  ? 64  ASP B CB  1 
ATOM   1589 C  CG  . ASP B 1 68  ? -17.94689 2.71912   30.55393 1.000 45.88151  ? 64  ASP B CG  1 
ATOM   1590 O  OD1 . ASP B 1 68  ? -17.18164 1.78382   30.86619 1.000 40.87061  ? 64  ASP B OD1 1 
ATOM   1591 O  OD2 . ASP B 1 68  ? -17.70969 3.48462   29.59565 1.000 45.60866  ? 64  ASP B OD2 1 
ATOM   1592 N  N   . PHE B 1 69  ? -19.83051 0.14189   31.87034 1.000 46.49917  ? 65  PHE B N   1 
ATOM   1593 C  CA  . PHE B 1 69  ? -19.80749 -1.31835  31.85935 1.000 44.03487  ? 65  PHE B CA  1 
ATOM   1594 C  C   . PHE B 1 69  ? -18.46166 -1.86834  31.39111 1.000 44.74671  ? 65  PHE B C   1 
ATOM   1595 O  O   . PHE B 1 69  ? -17.86740 -2.67839  32.12223 1.000 37.74257  ? 65  PHE B O   1 
ATOM   1596 C  CB  . PHE B 1 69  ? -20.98457 -1.85277  31.03511 1.000 41.45290  ? 65  PHE B CB  1 
ATOM   1597 C  CG  . PHE B 1 69  ? -21.28030 -3.31125  31.26094 1.000 40.26532  ? 65  PHE B CG  1 
ATOM   1598 C  CD1 . PHE B 1 69  ? -21.96132 -3.72351  32.39425 1.000 37.40044  ? 65  PHE B CD1 1 
ATOM   1599 C  CD2 . PHE B 1 69  ? -20.91758 -4.26386  30.32156 1.000 39.73635  ? 65  PHE B CD2 1 
ATOM   1600 C  CE1 . PHE B 1 69  ? -22.24677 -5.06038  32.60424 1.000 42.74537  ? 65  PHE B CE1 1 
ATOM   1601 C  CE2 . PHE B 1 69  ? -21.20574 -5.60353  30.52224 1.000 43.45054  ? 65  PHE B CE2 1 
ATOM   1602 C  CZ  . PHE B 1 69  ? -21.87107 -6.00153  31.66615 1.000 43.66447  ? 65  PHE B CZ  1 
ATOM   1603 N  N   . PRO B 1 70  ? -17.91808 -1.47531  30.22664 1.000 45.08591  ? 66  PRO B N   1 
ATOM   1604 C  CA  . PRO B 1 70  ? -16.59822 -2.01349  29.84398 1.000 45.71412  ? 66  PRO B CA  1 
ATOM   1605 C  C   . PRO B 1 70  ? -15.51648 -1.76172  30.88050 1.000 47.86645  ? 66  PRO B C   1 
ATOM   1606 O  O   . PRO B 1 70  ? -14.71577 -2.66116  31.16424 1.000 41.79314  ? 66  PRO B O   1 
ATOM   1607 C  CB  . PRO B 1 70  ? -16.30157 -1.28340  28.52856 1.000 43.80770  ? 66  PRO B CB  1 
ATOM   1608 C  CG  . PRO B 1 70  ? -17.64270 -1.02383  27.95528 1.000 48.78893  ? 66  PRO B CG  1 
ATOM   1609 C  CD  . PRO B 1 70  ? -18.49229 -0.65697  29.14048 1.000 42.79361  ? 66  PRO B CD  1 
ATOM   1610 N  N   . GLU B 1 71  ? -15.47382 -0.55773  31.45877 1.000 39.69221  ? 67  GLU B N   1 
ATOM   1611 C  CA  . GLU B 1 71  ? -14.48755 -0.26084  32.49336 1.000 39.86023  ? 67  GLU B CA  1 
ATOM   1612 C  C   . GLU B 1 71  ? -14.71297 -1.10299  33.74126 1.000 37.61119  ? 67  GLU B C   1 
ATOM   1613 O  O   . GLU B 1 71  ? -13.75108 -1.46119  34.42977 1.000 39.83749  ? 67  GLU B O   1 
ATOM   1614 C  CB  . GLU B 1 71  ? -14.52986 1.22630   32.84434 1.000 37.86545  ? 67  GLU B CB  1 
ATOM   1615 C  CG  . GLU B 1 71  ? -14.16497 2.14435   31.69454 1.000 43.78906  ? 67  GLU B CG  1 
ATOM   1616 C  CD  . GLU B 1 71  ? -14.53082 3.58712   31.96991 1.000 46.61674  ? 67  GLU B CD  1 
ATOM   1617 O  OE1 . GLU B 1 71  ? -15.58520 3.82025   32.59560 1.000 40.41239  ? 67  GLU B OE1 1 
ATOM   1618 O  OE2 . GLU B 1 71  ? -13.77014 4.48650   31.55525 1.000 51.65595  ? 67  GLU B OE2 1 
ATOM   1619 N  N   . PHE B 1 72  ? -15.97175 -1.42675  34.04701 1.000 43.53730  ? 68  PHE B N   1 
ATOM   1620 C  CA  . PHE B 1 72  ? -16.27041 -2.26650  35.20309 1.000 46.16971  ? 68  PHE B CA  1 
ATOM   1621 C  C   . PHE B 1 72  ? -15.73306 -3.68123  35.01681 1.000 46.61103  ? 68  PHE B C   1 
ATOM   1622 O  O   . PHE B 1 72  ? -15.14220 -4.25271  35.94032 1.000 46.42893  ? 68  PHE B O   1 
ATOM   1623 C  CB  . PHE B 1 72  ? -17.77953 -2.28772  35.44835 1.000 35.29263  ? 68  PHE B CB  1 
ATOM   1624 C  CG  . PHE B 1 72  ? -18.21105 -3.25729  36.50997 1.000 45.42791  ? 68  PHE B CG  1 
ATOM   1625 C  CD1 . PHE B 1 72  ? -18.66758 -4.52075  36.17076 1.000 43.14506  ? 68  PHE B CD1 1 
ATOM   1626 C  CD2 . PHE B 1 72  ? -18.16585 -2.90356  37.84800 1.000 46.05098  ? 68  PHE B CD2 1 
ATOM   1627 C  CE1 . PHE B 1 72  ? -19.06282 -5.41572  37.14669 1.000 48.56631  ? 68  PHE B CE1 1 
ATOM   1628 C  CE2 . PHE B 1 72  ? -18.56292 -3.79280  38.82793 1.000 43.61874  ? 68  PHE B CE2 1 
ATOM   1629 C  CZ  . PHE B 1 72  ? -19.01094 -5.05099  38.47687 1.000 48.59579  ? 68  PHE B CZ  1 
ATOM   1630 N  N   . LEU B 1 73  ? -15.93705 -4.26651  33.83399 1.000 46.40929  ? 69  LEU B N   1 
ATOM   1631 C  CA  . LEU B 1 73  ? -15.40185 -5.59677  33.56175 1.000 44.58395  ? 69  LEU B CA  1 
ATOM   1632 C  C   . LEU B 1 73  ? -13.87673 -5.60017  33.52132 1.000 49.56457  ? 69  LEU B C   1 
ATOM   1633 O  O   . LEU B 1 73  ? -13.25237 -6.62047  33.83857 1.000 45.39067  ? 69  LEU B O   1 
ATOM   1634 C  CB  . LEU B 1 73  ? -15.97790 -6.13500  32.25099 1.000 44.23790  ? 69  LEU B CB  1 
ATOM   1635 C  CG  . LEU B 1 73  ? -17.39937 -6.69832  32.13957 1.000 45.60800  ? 69  LEU B CG  1 
ATOM   1636 C  CD1 . LEU B 1 73  ? -18.46713 -5.74480  32.63861 1.000 45.84107  ? 69  LEU B CD1 1 
ATOM   1637 C  CD2 . LEU B 1 73  ? -17.66444 -7.07991  30.68462 1.000 50.90294  ? 69  LEU B CD2 1 
ATOM   1638 N  N   . THR B 1 74  ? -13.26063 -4.48117  33.12994 1.000 50.39130  ? 70  THR B N   1 
ATOM   1639 C  CA  . THR B 1 74  ? -11.80441 -4.38861  33.17440 1.000 48.65661  ? 70  THR B CA  1 
ATOM   1640 C  C   . THR B 1 74  ? -11.29687 -4.47172  34.60860 1.000 49.14668  ? 70  THR B C   1 
ATOM   1641 O  O   . THR B 1 74  ? -10.28025 -5.12206  34.88169 1.000 54.97989  ? 70  THR B O   1 
ATOM   1642 C  CB  . THR B 1 74  ? -11.34147 -3.08926  32.51320 1.000 52.05268  ? 70  THR B CB  1 
ATOM   1643 O  OG1 . THR B 1 74  ? -11.63628 -3.13221  31.11154 1.000 48.24167  ? 70  THR B OG1 1 
ATOM   1644 C  CG2 . THR B 1 74  ? -9.84331  -2.88349  32.70493 1.000 45.65475  ? 70  THR B CG2 1 
HETATM 1645 N  N   . MSE B 1 75  ? -11.99774 -3.82925  35.53747 1.000 47.55560  ? 71  MSE B N   1 
HETATM 1646 C  CA  . MSE B 1 75  ? -11.62957 -3.87026  36.94492 1.000 58.49310  ? 71  MSE B CA  1 
HETATM 1647 C  C   . MSE B 1 75  ? -11.80708 -5.27112  37.51823 1.000 65.75022  ? 71  MSE B C   1 
HETATM 1648 O  O   . MSE B 1 75  ? -10.91673 -5.79199  38.18966 1.000 61.76580  ? 71  MSE B O   1 
HETATM 1649 C  CB  . MSE B 1 75  ? -12.46220 -2.87005  37.74990 1.000 48.72464  ? 71  MSE B CB  1 
HETATM 1650 C  CG  . MSE B 1 75  ? -12.33334 -3.03325  39.25579 1.000 59.00394  ? 71  MSE B CG  1 
HETATM 1651 SE SE  . MSE B 1 75  ? -10.90979 -1.93459  40.01693 1.000 123.72537 ? 71  MSE B SE  1 
HETATM 1652 C  CE  . MSE B 1 75  ? -9.38252  -3.09598  39.66149 1.000 67.32781  ? 71  MSE B CE  1 
HETATM 1653 N  N   . MSE B 1 76  ? -12.95948 -5.87684  37.24294 1.000 57.96920  ? 72  MSE B N   1 
HETATM 1654 C  CA  . MSE B 1 76  ? -13.26478 -7.22051  37.72656 1.000 63.32713  ? 72  MSE B CA  1 
HETATM 1655 C  C   . MSE B 1 76  ? -12.25691 -8.24065  37.20550 1.000 65.41590  ? 72  MSE B C   1 
HETATM 1656 O  O   . MSE B 1 76  ? -12.02857 -9.27724  37.82914 1.000 63.69632  ? 72  MSE B O   1 
HETATM 1657 C  CB  . MSE B 1 76  ? -14.68475 -7.62473  37.32173 1.000 58.10891  ? 72  MSE B CB  1 
HETATM 1658 C  CG  . MSE B 1 76  ? -15.75956 -7.15015  38.28816 1.000 65.27814  ? 72  MSE B CG  1 
HETATM 1659 SE SE  . MSE B 1 76  ? -15.10985 -7.02559  40.12420 1.000 105.22368 ? 72  MSE B SE  1 
HETATM 1660 C  CE  . MSE B 1 76  ? -16.14245 -5.48406  40.71920 1.000 68.06786  ? 72  MSE B CE  1 
ATOM   1661 N  N   . ALA B 1 77  ? -11.65418 -7.93596  36.05430 1.000 56.73425  ? 73  ALA B N   1 
ATOM   1662 C  CA  . ALA B 1 77  ? -10.60174 -8.79439  35.52295 1.000 60.87943  ? 73  ALA B CA  1 
ATOM   1663 C  C   . ALA B 1 77  ? -9.30183  -8.61695  36.29769 1.000 70.38001  ? 73  ALA B C   1 
ATOM   1664 O  O   . ALA B 1 77  ? -8.55726  -9.58358  36.50065 1.000 70.17019  ? 73  ALA B O   1 
ATOM   1665 C  CB  . ALA B 1 77  ? -10.38709 -8.50324  34.03820 1.000 60.39947  ? 73  ALA B CB  1 
ATOM   1666 N  N   . ARG B 1 78  ? -9.01379  -7.38978  36.73856 1.000 71.94586  ? 74  ARG B N   1 
ATOM   1667 C  CA  . ARG B 1 78  ? -7.78109  -7.12703  37.47553 1.000 65.89980  ? 74  ARG B CA  1 
ATOM   1668 C  C   . ARG B 1 78  ? -7.79956  -7.80833  38.83935 1.000 67.54125  ? 74  ARG B C   1 
ATOM   1669 O  O   . ARG B 1 78  ? -6.98490  -8.69688  39.11474 1.000 65.88256  ? 74  ARG B O   1 
ATOM   1670 C  CB  . ARG B 1 78  ? -7.57057  -5.61795  37.62206 1.000 69.10543  ? 74  ARG B CB  1 
ATOM   1671 C  CG  . ARG B 1 78  ? -6.15550  -5.15033  37.30682 1.000 62.32231  ? 74  ARG B CG  1 
ATOM   1672 C  CD  . ARG B 1 78  ? -6.06380  -3.63183  37.26961 1.000 69.72538  ? 74  ARG B CD  1 
ATOM   1673 N  NE  . ARG B 1 78  ? -6.23717  -3.10366  35.92129 1.000 71.30236  ? 74  ARG B NE  1 
ATOM   1674 C  CZ  . ARG B 1 78  ? -6.33068  -1.81347  35.62857 1.000 65.41134  ? 74  ARG B CZ  1 
ATOM   1675 N  NH1 . ARG B 1 78  ? -6.28908  -0.88599  36.57107 1.000 63.29568  ? 74  ARG B NH1 1 
ATOM   1676 N  NH2 . ARG B 1 78  ? -6.46917  -1.44432  34.35828 1.000 60.42833  ? 74  ARG B NH2 1 
ATOM   1677 N  N   . LYS B 1 79  ? -8.72131  -7.40467  39.70822 1.000 63.12947  ? 75  LYS B N   1 
ATOM   1678 C  CA  . LYS B 1 79  ? -8.82737  -8.01135  41.03098 1.000 66.53801  ? 75  LYS B CA  1 
ATOM   1679 C  C   . LYS B 1 79  ? -9.48720  -9.38294  40.94449 1.000 68.22119  ? 75  LYS B C   1 
ATOM   1680 O  O   . LYS B 1 79  ? -8.82221  -10.41081 41.07207 1.000 63.18582  ? 75  LYS B O   1 
ATOM   1681 C  CB  . LYS B 1 79  ? -9.61454  -7.11081  41.98764 1.000 63.33591  ? 75  LYS B CB  1 
ATOM   1682 C  CG  . LYS B 1 79  ? -10.61110 -6.19019  41.30788 1.000 64.46605  ? 75  LYS B CG  1 
ATOM   1683 C  CD  . LYS B 1 79  ? -11.18225 -5.17449  42.28459 1.000 58.18400  ? 75  LYS B CD  1 
ATOM   1684 C  CE  . LYS B 1 79  ? -10.08103 -4.39438  42.98399 1.000 67.45396  ? 75  LYS B CE  1 
ATOM   1685 N  NZ  . LYS B 1 79  ? -10.62550 -3.44501  43.99401 1.000 65.73138  ? 75  LYS B NZ  1 
ATOM   1686 N  N   . SER B 1 85  ? -3.49157  -9.73219  46.34399 1.000 52.28194  ? 81  SER B N   1 
ATOM   1687 C  CA  . SER B 1 85  ? -3.67200  -9.32701  47.73320 1.000 57.99500  ? 81  SER B CA  1 
ATOM   1688 C  C   . SER B 1 85  ? -4.57632  -10.30249 48.48007 1.000 59.96851  ? 81  SER B C   1 
ATOM   1689 O  O   . SER B 1 85  ? -5.80248  -10.22057 48.39490 1.000 53.57436  ? 81  SER B O   1 
ATOM   1690 C  CB  . SER B 1 85  ? -4.24547  -7.91086  47.80705 1.000 56.34879  ? 81  SER B CB  1 
ATOM   1691 O  OG  . SER B 1 85  ? -3.23963  -6.94060  47.57889 1.000 63.83280  ? 81  SER B OG  1 
ATOM   1692 N  N   . GLU B 1 86  ? -3.95403  -11.22488 49.21879 1.000 60.88677  ? 82  GLU B N   1 
ATOM   1693 C  CA  . GLU B 1 86  ? -4.71273  -12.23647 49.94905 1.000 56.03328  ? 82  GLU B CA  1 
ATOM   1694 C  C   . GLU B 1 86  ? -5.51799  -11.61551 51.08549 1.000 52.15286  ? 82  GLU B C   1 
ATOM   1695 O  O   . GLU B 1 86  ? -6.63500  -12.05981 51.37696 1.000 47.48121  ? 82  GLU B O   1 
ATOM   1696 C  CB  . GLU B 1 86  ? -3.75969  -13.31134 50.47843 1.000 46.84146  ? 82  GLU B CB  1 
ATOM   1697 C  CG  . GLU B 1 86  ? -4.14564  -13.91409 51.82313 1.000 44.01473  ? 82  GLU B CG  1 
ATOM   1698 C  CD  . GLU B 1 86  ? -4.99778  -15.16005 51.68069 1.000 56.21896  ? 82  GLU B CD  1 
ATOM   1699 O  OE1 . GLU B 1 86  ? -5.38914  -15.49024 50.54025 1.000 57.47224  ? 82  GLU B OE1 1 
ATOM   1700 O  OE2 . GLU B 1 86  ? -5.27728  -15.81265 52.70947 1.000 55.35359  ? 82  GLU B OE2 1 
ATOM   1701 N  N   . GLU B 1 87  ? -4.96931  -10.58278 51.73220 1.000 46.14936  ? 83  GLU B N   1 
ATOM   1702 C  CA  . GLU B 1 87  ? -5.65659  -9.95007  52.85481 1.000 44.76134  ? 83  GLU B CA  1 
ATOM   1703 C  C   . GLU B 1 87  ? -7.00816  -9.38543  52.43358 1.000 47.28917  ? 83  GLU B C   1 
ATOM   1704 O  O   . GLU B 1 87  ? -7.97394  -9.42538  53.20609 1.000 39.44917  ? 83  GLU B O   1 
ATOM   1705 C  CB  . GLU B 1 87  ? -4.77317  -8.85292  53.45419 1.000 45.13041  ? 83  GLU B CB  1 
ATOM   1706 C  CG  . GLU B 1 87  ? -5.49759  -7.88259  54.38211 1.000 48.11081  ? 83  GLU B CG  1 
ATOM   1707 C  CD  . GLU B 1 87  ? -5.87902  -8.49849  55.71817 1.000 47.99573  ? 83  GLU B CD  1 
ATOM   1708 O  OE1 . GLU B 1 87  ? -6.58725  -7.82666  56.49803 1.000 38.03457  ? 83  GLU B OE1 1 
ATOM   1709 O  OE2 . GLU B 1 87  ? -5.46343  -9.64300  55.99910 1.000 43.86927  ? 83  GLU B OE2 1 
ATOM   1710 N  N   . GLU B 1 88  ? -7.09721  -8.85847  51.20877 1.000 52.06966  ? 84  GLU B N   1 
ATOM   1711 C  CA  . GLU B 1 88  ? -8.37472  -8.36198  50.70817 1.000 44.65594  ? 84  GLU B CA  1 
ATOM   1712 C  C   . GLU B 1 88  ? -9.42191  -9.46534  50.65691 1.000 45.87453  ? 84  GLU B C   1 
ATOM   1713 O  O   . GLU B 1 88  ? -10.60960 -9.20466  50.87712 1.000 31.55048  ? 84  GLU B O   1 
ATOM   1714 C  CB  . GLU B 1 88  ? -8.19453  -7.74560  49.32068 1.000 49.29540  ? 84  GLU B CB  1 
ATOM   1715 C  CG  . GLU B 1 88  ? -7.69541  -6.31304  49.33220 1.000 55.43790  ? 84  GLU B CG  1 
ATOM   1716 C  CD  . GLU B 1 88  ? -7.02518  -5.92245  48.03032 1.000 67.25550  ? 84  GLU B CD  1 
ATOM   1717 O  OE1 . GLU B 1 88  ? -7.35471  -6.52724  46.98838 1.000 70.40835  ? 84  GLU B OE1 1 
ATOM   1718 O  OE2 . GLU B 1 88  ? -6.16557  -5.01644  48.04873 1.000 73.77210  ? 84  GLU B OE2 1 
ATOM   1719 N  N   . ILE B 1 89  ? -9.00367  -10.69871 50.37248 1.000 38.88542  ? 85  ILE B N   1 
ATOM   1720 C  CA  . ILE B 1 89  ? -9.94581  -11.80937 50.29223 1.000 38.71487  ? 85  ILE B CA  1 
ATOM   1721 C  C   . ILE B 1 89  ? -10.36888 -12.26327 51.68251 1.000 33.79139  ? 85  ILE B C   1 
ATOM   1722 O  O   . ILE B 1 89  ? -11.54401 -12.56830 51.91430 1.000 30.16549  ? 85  ILE B O   1 
ATOM   1723 C  CB  . ILE B 1 89  ? -9.33389  -12.96196 49.47640 1.000 36.21718  ? 85  ILE B CB  1 
ATOM   1724 C  CG1 . ILE B 1 89  ? -8.79940  -12.43994 48.14040 1.000 43.87265  ? 85  ILE B CG1 1 
ATOM   1725 C  CG2 . ILE B 1 89  ? -10.35977 -14.05848 49.24657 1.000 34.82515  ? 85  ILE B CG2 1 
ATOM   1726 C  CD1 . ILE B 1 89  ? -9.84650  -11.74477 47.29665 1.000 40.36663  ? 85  ILE B CD1 1 
ATOM   1727 N  N   . ARG B 1 90  ? -9.42601  -12.31821 52.62714 1.000 32.47061  ? 86  ARG B N   1 
ATOM   1728 C  CA  . ARG B 1 90  ? -9.78281  -12.66617 53.99804 1.000 30.91187  ? 86  ARG B CA  1 
ATOM   1729 C  C   . ARG B 1 90  ? -10.67916 -11.60895 54.62823 1.000 34.47311  ? 86  ARG B C   1 
ATOM   1730 O  O   . ARG B 1 90  ? -11.56792 -11.94453 55.41946 1.000 25.30658  ? 86  ARG B O   1 
ATOM   1731 C  CB  . ARG B 1 90  ? -8.52296  -12.86355 54.84054 1.000 43.26470  ? 86  ARG B CB  1 
ATOM   1732 C  CG  . ARG B 1 90  ? -8.16205  -14.32087 55.07855 1.000 36.86164  ? 86  ARG B CG  1 
ATOM   1733 C  CD  . ARG B 1 90  ? -6.67716  -14.48707 55.37017 1.000 56.87275  ? 86  ARG B CD  1 
ATOM   1734 N  NE  . ARG B 1 90  ? -6.14462  -15.75110 54.87236 1.000 50.08802  ? 86  ARG B NE  1 
ATOM   1735 C  CZ  . ARG B 1 90  ? -6.43487  -16.94459 55.37332 1.000 47.90050  ? 86  ARG B CZ  1 
ATOM   1736 N  NH1 . ARG B 1 90  ? -7.25991  -17.08374 56.39806 1.000 43.25558  ? 86  ARG B NH1 1 
ATOM   1737 N  NH2 . ARG B 1 90  ? -5.87683  -18.02616 54.83642 1.000 51.03992  ? 86  ARG B NH2 1 
ATOM   1738 N  N   . GLU B 1 91  ? -10.46022 -10.33526 54.29380 1.000 28.14669  ? 87  GLU B N   1 
ATOM   1739 C  CA  . GLU B 1 91  ? -11.33241 -9.27336  54.78387 1.000 35.54695  ? 87  GLU B CA  1 
ATOM   1740 C  C   . GLU B 1 91  ? -12.75718 -9.46606  54.28100 1.000 30.22645  ? 87  GLU B C   1 
ATOM   1741 O  O   . GLU B 1 91  ? -13.72010 -9.35014  55.04738 1.000 35.28281  ? 87  GLU B O   1 
ATOM   1742 C  CB  . GLU B 1 91  ? -10.78692 -7.90938  54.35468 1.000 41.48861  ? 87  GLU B CB  1 
ATOM   1743 C  CG  . GLU B 1 91  ? -11.74971 -6.75180  54.58262 1.000 38.59254  ? 87  GLU B CG  1 
ATOM   1744 C  CD  . GLU B 1 91  ? -12.15382 -6.60270  56.03642 1.000 50.49908  ? 87  GLU B CD  1 
ATOM   1745 O  OE1 . GLU B 1 91  ? -11.25483 -6.52583  56.90046 1.000 49.61799  ? 87  GLU B OE1 1 
ATOM   1746 O  OE2 . GLU B 1 91  ? -13.37097 -6.56114  56.31570 1.000 46.88572  ? 87  GLU B OE2 1 
ATOM   1747 N  N   . ALA B 1 92  ? -12.90872 -9.76886  52.98877 1.000 24.99338  ? 88  ALA B N   1 
ATOM   1748 C  CA  . ALA B 1 92  ? -14.23915 -9.98736  52.43107 1.000 30.48558  ? 88  ALA B CA  1 
ATOM   1749 C  C   . ALA B 1 92  ? -14.89267 -11.22374 53.03345 1.000 21.75601  ? 88  ALA B C   1 
ATOM   1750 O  O   . ALA B 1 92  ? -16.09966 -11.22798 53.30184 1.000 26.97325  ? 88  ALA B O   1 
ATOM   1751 C  CB  . ALA B 1 92  ? -14.15675 -10.11057 50.91038 1.000 28.32479  ? 88  ALA B CB  1 
ATOM   1752 N  N   . PHE B 1 93  ? -14.10845 -12.28321 53.25187 1.000 21.00395  ? 89  PHE B N   1 
ATOM   1753 C  CA  . PHE B 1 93  ? -14.64222 -13.49177 53.87178 1.000 24.55192  ? 89  PHE B CA  1 
ATOM   1754 C  C   . PHE B 1 93  ? -15.21140 -13.19444 55.25348 1.000 25.11458  ? 89  PHE B C   1 
ATOM   1755 O  O   . PHE B 1 93  ? -16.28584 -13.69290 55.61134 1.000 20.38285  ? 89  PHE B O   1 
ATOM   1756 C  CB  . PHE B 1 93  ? -13.54953 -14.55937 53.95239 1.000 21.35224  ? 89  PHE B CB  1 
ATOM   1757 C  CG  . PHE B 1 93  ? -14.01554 -15.86907 54.52694 1.000 25.23501  ? 89  PHE B CG  1 
ATOM   1758 C  CD1 . PHE B 1 93  ? -14.64758 -16.80691 53.72695 1.000 23.53554  ? 89  PHE B CD1 1 
ATOM   1759 C  CD2 . PHE B 1 93  ? -13.81242 -16.16605 55.86557 1.000 25.86174  ? 89  PHE B CD2 1 
ATOM   1760 C  CE1 . PHE B 1 93  ? -15.07322 -18.01412 54.25172 1.000 20.77722  ? 89  PHE B CE1 1 
ATOM   1761 C  CE2 . PHE B 1 93  ? -14.23725 -17.37054 56.39652 1.000 26.46804  ? 89  PHE B CE2 1 
ATOM   1762 C  CZ  . PHE B 1 93  ? -14.86951 -18.29499 55.58803 1.000 17.04308  ? 89  PHE B CZ  1 
ATOM   1763 N  N   . ARG B 1 94  ? -14.50790 -12.37382 56.04033 1.000 15.95189  ? 90  ARG B N   1 
ATOM   1764 C  CA  . ARG B 1 94  ? -14.99988 -12.00793 57.36476 1.000 17.99640  ? 90  ARG B CA  1 
ATOM   1765 C  C   . ARG B 1 94  ? -16.29817 -11.21633 57.28528 1.000 18.68909  ? 90  ARG B C   1 
ATOM   1766 O  O   . ARG B 1 94  ? -17.13939 -11.31586 58.18591 1.000 21.56985  ? 90  ARG B O   1 
ATOM   1767 C  CB  . ARG B 1 94  ? -13.94037 -11.20281 58.11806 1.000 29.99380  ? 90  ARG B CB  1 
ATOM   1768 C  CG  . ARG B 1 94  ? -12.74934 -12.02222 58.58421 1.000 29.14097  ? 90  ARG B CG  1 
ATOM   1769 C  CD  . ARG B 1 94  ? -11.84910 -11.20891 59.49978 1.000 39.07075  ? 90  ARG B CD  1 
ATOM   1770 N  NE  . ARG B 1 94  ? -11.27851 -10.05023 58.82280 1.000 34.48145  ? 90  ARG B NE  1 
ATOM   1771 C  CZ  . ARG B 1 94  ? -10.04813 -10.00296 58.33078 1.000 39.37514  ? 90  ARG B CZ  1 
ATOM   1772 N  NH1 . ARG B 1 94  ? -9.23068  -11.03986 58.41376 1.000 36.44477  ? 90  ARG B NH1 1 
ATOM   1773 N  NH2 . ARG B 1 94  ? -9.62729  -8.88773  57.74046 1.000 36.96648  ? 90  ARG B NH2 1 
ATOM   1774 N  N   . VAL B 1 95  ? -16.47480 -10.42026 56.22725 1.000 20.60877  ? 91  VAL B N   1 
ATOM   1775 C  CA  . VAL B 1 95  ? -17.72107 -9.67817  56.05442 1.000 23.35468  ? 91  VAL B CA  1 
ATOM   1776 C  C   . VAL B 1 95  ? -18.89125 -10.64074 55.90031 1.000 23.95041  ? 91  VAL B C   1 
ATOM   1777 O  O   . VAL B 1 95  ? -19.96512 -10.43799 56.48050 1.000 20.90912  ? 91  VAL B O   1 
ATOM   1778 C  CB  . VAL B 1 95  ? -17.60999 -8.71960  54.85345 1.000 28.00325  ? 91  VAL B CB  1 
ATOM   1779 C  CG1 . VAL B 1 95  ? -18.94345 -8.03086  54.59028 1.000 29.24012  ? 91  VAL B CG1 1 
ATOM   1780 C  CG2 . VAL B 1 95  ? -16.51200 -7.69340  55.09340 1.000 26.50636  ? 91  VAL B CG2 1 
ATOM   1781 N  N   . PHE B 1 96  ? -18.69763 -11.71005 55.12688 1.000 26.30806  ? 92  PHE B N   1 
ATOM   1782 C  CA  . PHE B 1 96  ? -19.74077 -12.71750 54.96763 1.000 27.72628  ? 92  PHE B CA  1 
ATOM   1783 C  C   . PHE B 1 96  ? -19.87739 -13.56212 56.22858 1.000 25.24813  ? 92  PHE B C   1 
ATOM   1784 O  O   . PHE B 1 96  ? -20.96476 -13.67204 56.80678 1.000 25.55049  ? 92  PHE B O   1 
ATOM   1785 C  CB  . PHE B 1 96  ? -19.42788 -13.60442 53.76181 1.000 21.53602  ? 92  PHE B CB  1 
ATOM   1786 C  CG  . PHE B 1 96  ? -19.61052 -12.92022 52.43868 1.000 31.34150  ? 92  PHE B CG  1 
ATOM   1787 C  CD1 . PHE B 1 96  ? -20.87069 -12.77665 51.88414 1.000 33.80068  ? 92  PHE B CD1 1 
ATOM   1788 C  CD2 . PHE B 1 96  ? -18.51838 -12.43170 51.74298 1.000 27.90202  ? 92  PHE B CD2 1 
ATOM   1789 C  CE1 . PHE B 1 96  ? -21.03615 -12.14880 50.66446 1.000 34.30332  ? 92  PHE B CE1 1 
ATOM   1790 C  CE2 . PHE B 1 96  ? -18.67846 -11.80556 50.52422 1.000 33.93302  ? 92  PHE B CE2 1 
ATOM   1791 C  CZ  . PHE B 1 96  ? -19.93920 -11.66443 49.98412 1.000 36.04439  ? 92  PHE B CZ  1 
ATOM   1792 N  N   . ASP B 1 97  ? -18.77439 -14.16994 56.66726 1.000 22.84007  ? 93  ASP B N   1 
ATOM   1793 C  CA  . ASP B 1 97  ? -18.75162 -15.03584 57.84613 1.000 22.36656  ? 93  ASP B CA  1 
ATOM   1794 C  C   . ASP B 1 97  ? -18.72154 -14.16035 59.09726 1.000 27.62120  ? 93  ASP B C   1 
ATOM   1795 O  O   . ASP B 1 97  ? -17.69374 -13.98913 59.75819 1.000 30.38126  ? 93  ASP B O   1 
ATOM   1796 C  CB  . ASP B 1 97  ? -17.55441 -15.97652 57.78143 1.000 23.37954  ? 93  ASP B CB  1 
ATOM   1797 C  CG  . ASP B 1 97  ? -17.48525 -16.91794 58.96245 1.000 23.13473  ? 93  ASP B CG  1 
ATOM   1798 O  OD1 . ASP B 1 97  ? -18.55346 -17.30475 59.47480 1.000 25.18432  ? 93  ASP B OD1 1 
ATOM   1799 O  OD2 . ASP B 1 97  ? -16.36033 -17.27448 59.37325 1.000 29.29754  ? 93  ASP B OD2 1 
ATOM   1800 N  N   . LYS B 1 98  ? -19.88850 -13.59901 59.42842 1.000 31.51217  ? 94  LYS B N   1 
ATOM   1801 C  CA  . LYS B 1 98  ? -19.96052 -12.63857 60.52614 1.000 31.33971  ? 94  LYS B CA  1 
ATOM   1802 C  C   . LYS B 1 98  ? -19.72636 -13.30409 61.87761 1.000 40.20728  ? 94  LYS B C   1 
ATOM   1803 O  O   . LYS B 1 98  ? -19.08787 -12.71608 62.75850 1.000 40.31657  ? 94  LYS B O   1 
ATOM   1804 C  CB  . LYS B 1 98  ? -21.30599 -11.91539 60.50673 1.000 33.05735  ? 94  LYS B CB  1 
ATOM   1805 C  CG  . LYS B 1 98  ? -21.35563 -10.74009 59.54197 1.000 37.53499  ? 94  LYS B CG  1 
ATOM   1806 C  CD  . LYS B 1 98  ? -22.54900 -10.83474 58.60932 1.000 34.64072  ? 94  LYS B CD  1 
ATOM   1807 C  CE  . LYS B 1 98  ? -22.94583 -9.46484  58.08197 1.000 33.33037  ? 94  LYS B CE  1 
ATOM   1808 N  NZ  . LYS B 1 98  ? -21.76137 -8.63923  57.71529 1.000 41.84533  ? 94  LYS B NZ  1 
ATOM   1809 N  N   . ASP B 1 99  ? -20.23074 -14.52266 62.06811 1.000 31.75439  ? 95  ASP B N   1 
ATOM   1810 C  CA  . ASP B 1 99  ? -19.99741 -15.21873 63.32740 1.000 35.83332  ? 95  ASP B CA  1 
ATOM   1811 C  C   . ASP B 1 99  ? -18.59849 -15.81869 63.42288 1.000 27.70820  ? 95  ASP B C   1 
ATOM   1812 O  O   . ASP B 1 99  ? -18.24993 -16.37287 64.47042 1.000 39.17521  ? 95  ASP B O   1 
ATOM   1813 C  CB  . ASP B 1 99  ? -21.07899 -16.28864 63.55436 1.000 30.59211  ? 95  ASP B CB  1 
ATOM   1814 C  CG  . ASP B 1 99  ? -20.90748 -17.52408 62.67806 1.000 30.14565  ? 95  ASP B CG  1 
ATOM   1815 O  OD1 . ASP B 1 99  ? -20.02392 -17.55037 61.79640 1.000 34.44285  ? 95  ASP B OD1 1 
ATOM   1816 O  OD2 . ASP B 1 99  ? -21.67617 -18.48718 62.88067 1.000 29.91300  ? 95  ASP B OD2 1 
ATOM   1817 N  N   . GLY B 1 100 ? -17.80036 -15.72490 62.36011 1.000 24.33325  ? 96  GLY B N   1 
ATOM   1818 C  CA  . GLY B 1 100 ? -16.40142 -16.10239 62.40072 1.000 25.40115  ? 96  GLY B CA  1 
ATOM   1819 C  C   . GLY B 1 100 ? -16.11248 -17.57946 62.52557 1.000 22.21439  ? 96  GLY B C   1 
ATOM   1820 O  O   . GLY B 1 100 ? -14.95727 -17.94570 62.75659 1.000 21.59734  ? 96  GLY B O   1 
ATOM   1821 N  N   . ASN B 1 101 ? -17.11322 -18.44491 62.36740 1.000 25.96252  ? 97  ASN B N   1 
ATOM   1822 C  CA  . ASN B 1 101 ? -16.90682 -19.87646 62.55236 1.000 23.60113  ? 97  ASN B CA  1 
ATOM   1823 C  C   . ASN B 1 101 ? -16.19873 -20.53952 61.37579 1.000 25.78045  ? 97  ASN B C   1 
ATOM   1824 O  O   . ASN B 1 101 ? -15.97879 -21.75469 61.41431 1.000 23.42207  ? 97  ASN B O   1 
ATOM   1825 C  CB  . ASN B 1 101 ? -18.24775 -20.57085 62.82291 1.000 23.02108  ? 97  ASN B CB  1 
ATOM   1826 C  CG  . ASN B 1 101 ? -19.05244 -20.82214 61.55864 1.000 20.05026  ? 97  ASN B CG  1 
ATOM   1827 O  OD1 . ASN B 1 101 ? -18.93690 -20.09465 60.57240 1.000 24.19608  ? 97  ASN B OD1 1 
ATOM   1828 N  ND2 . ASN B 1 101 ? -19.87866 -21.86110 61.58685 1.000 23.84101  ? 97  ASN B ND2 1 
ATOM   1829 N  N   . GLY B 1 102 ? -15.83550 -19.78195 60.34361 1.000 23.66381  ? 98  GLY B N   1 
ATOM   1830 C  CA  . GLY B 1 102 ? -15.12018 -20.32306 59.20654 1.000 24.18766  ? 98  GLY B CA  1 
ATOM   1831 C  C   . GLY B 1 102 ? -15.98235 -20.85901 58.08647 1.000 23.01477  ? 98  GLY B C   1 
ATOM   1832 O  O   . GLY B 1 102 ? -15.44592 -21.47541 57.15798 1.000 26.21577  ? 98  GLY B O   1 
ATOM   1833 N  N   . TYR B 1 103 ? -17.29564 -20.64391 58.13601 1.000 19.68764  ? 99  TYR B N   1 
ATOM   1834 C  CA  . TYR B 1 103 ? -18.21026 -21.16635 57.12669 1.000 24.32708  ? 99  TYR B CA  1 
ATOM   1835 C  C   . TYR B 1 103 ? -19.29873 -20.13814 56.86990 1.000 20.35086  ? 99  TYR B C   1 
ATOM   1836 O  O   . TYR B 1 103 ? -19.98548 -19.71791 57.80478 1.000 17.88041  ? 99  TYR B O   1 
ATOM   1837 C  CB  . TYR B 1 103 ? -18.82535 -22.49620 57.57578 1.000 21.81105  ? 99  TYR B CB  1 
ATOM   1838 C  CG  . TYR B 1 103 ? -17.81576 -23.60560 57.75814 1.000 20.94035  ? 99  TYR B CG  1 
ATOM   1839 C  CD1 . TYR B 1 103 ? -17.43419 -24.40354 56.68889 1.000 21.23682  ? 99  TYR B CD1 1 
ATOM   1840 C  CD2 . TYR B 1 103 ? -17.24021 -23.85133 58.99841 1.000 17.13830  ? 99  TYR B CD2 1 
ATOM   1841 C  CE1 . TYR B 1 103 ? -16.51001 -25.41858 56.84884 1.000 16.15363  ? 99  TYR B CE1 1 
ATOM   1842 C  CE2 . TYR B 1 103 ? -16.31332 -24.86434 59.16720 1.000 18.58588  ? 99  TYR B CE2 1 
ATOM   1843 C  CZ  . TYR B 1 103 ? -15.95392 -25.64518 58.08882 1.000 19.70193  ? 99  TYR B CZ  1 
ATOM   1844 O  OH  . TYR B 1 103 ? -15.03245 -26.65476 58.24995 1.000 30.55114  ? 99  TYR B OH  1 
ATOM   1845 N  N   . ILE B 1 104 ? -19.45617 -19.73779 55.61159 1.000 22.42640  ? 100 ILE B N   1 
ATOM   1846 C  CA  . ILE B 1 104 ? -20.51989 -18.81396 55.23133 1.000 19.93624  ? 100 ILE B CA  1 
ATOM   1847 C  C   . ILE B 1 104 ? -21.79394 -19.61357 54.99298 1.000 19.62145  ? 100 ILE B C   1 
ATOM   1848 O  O   . ILE B 1 104 ? -21.81248 -20.54244 54.17918 1.000 17.61530  ? 100 ILE B O   1 
ATOM   1849 C  CB  . ILE B 1 104 ? -20.14063 -18.00420 53.98399 1.000 19.73730  ? 100 ILE B CB  1 
ATOM   1850 C  CG1 . ILE B 1 104 ? -18.80962 -17.28228 54.19065 1.000 18.03294  ? 100 ILE B CG1 1 
ATOM   1851 C  CG2 . ILE B 1 104 ? -21.23963 -17.00817 53.64792 1.000 19.77770  ? 100 ILE B CG2 1 
ATOM   1852 C  CD1 . ILE B 1 104 ? -18.13634 -16.88920 52.89576 1.000 17.65419  ? 100 ILE B CD1 1 
ATOM   1853 N  N   . SER B 1 105 ? -22.85822 -19.25243 55.69940 1.000 20.02192  ? 101 SER B N   1 
ATOM   1854 C  CA  . SER B 1 105 ? -24.15231 -19.89953 55.55706 1.000 23.94973  ? 101 SER B CA  1 
ATOM   1855 C  C   . SER B 1 105 ? -25.02680 -19.12914 54.57418 1.000 25.17363  ? 101 SER B C   1 
ATOM   1856 O  O   . SER B 1 105 ? -24.70606 -18.01610 54.15114 1.000 20.78891  ? 101 SER B O   1 
ATOM   1857 C  CB  . SER B 1 105 ? -24.84873 -20.00874 56.91657 1.000 30.90786  ? 101 SER B CB  1 
ATOM   1858 O  OG  . SER B 1 105 ? -25.21811 -18.72808 57.40000 1.000 32.59774  ? 101 SER B OG  1 
ATOM   1859 N  N   . ALA B 1 106 ? -26.15072 -19.74775 54.20597 1.000 21.19700  ? 102 ALA B N   1 
ATOM   1860 C  CA  . ALA B 1 106 ? -27.12945 -19.05167 53.37932 1.000 26.87635  ? 102 ALA B CA  1 
ATOM   1861 C  C   . ALA B 1 106 ? -27.71560 -17.85808 54.12105 1.000 21.91906  ? 102 ALA B C   1 
ATOM   1862 O  O   . ALA B 1 106 ? -28.01711 -16.82507 53.51196 1.000 24.44487  ? 102 ALA B O   1 
ATOM   1863 C  CB  . ALA B 1 106 ? -28.23468 -20.01446 52.94536 1.000 30.42681  ? 102 ALA B CB  1 
ATOM   1864 N  N   . ALA B 1 107 ? -27.87898 -17.98038 55.44102 1.000 19.20906  ? 103 ALA B N   1 
ATOM   1865 C  CA  . ALA B 1 107 ? -28.36770 -16.85706 56.23237 1.000 22.32561  ? 103 ALA B CA  1 
ATOM   1866 C  C   . ALA B 1 107 ? -27.35464 -15.71882 56.26074 1.000 21.91609  ? 103 ALA B C   1 
ATOM   1867 O  O   . ALA B 1 107 ? -27.72782 -14.54656 56.13716 1.000 24.49717  ? 103 ALA B O   1 
ATOM   1868 C  CB  . ALA B 1 107 ? -28.70023 -17.31934 57.65080 1.000 26.14127  ? 103 ALA B CB  1 
ATOM   1869 N  N   . GLU B 1 108 ? -26.06844 -16.04210 56.42004 1.000 25.74602  ? 104 GLU B N   1 
ATOM   1870 C  CA  . GLU B 1 108 ? -25.04303 -15.00267 56.41842 1.000 25.48636  ? 104 GLU B CA  1 
ATOM   1871 C  C   . GLU B 1 108 ? -24.93671 -14.33552 55.05291 1.000 25.49775  ? 104 GLU B C   1 
ATOM   1872 O  O   . GLU B 1 108 ? -24.80511 -13.10882 54.96407 1.000 27.82669  ? 104 GLU B O   1 
ATOM   1873 C  CB  . GLU B 1 108 ? -23.69565 -15.59076 56.83550 1.000 21.19155  ? 104 GLU B CB  1 
ATOM   1874 C  CG  . GLU B 1 108 ? -23.58226 -15.88996 58.31984 1.000 25.55654  ? 104 GLU B CG  1 
ATOM   1875 C  CD  . GLU B 1 108 ? -22.24651 -16.50722 58.68625 1.000 23.23108  ? 104 GLU B CD  1 
ATOM   1876 O  OE1 . GLU B 1 108 ? -21.76598 -17.37877 57.93169 1.000 23.34338  ? 104 GLU B OE1 1 
ATOM   1877 O  OE2 . GLU B 1 108 ? -21.67907 -16.12183 59.72909 1.000 22.68060  ? 104 GLU B OE2 1 
ATOM   1878 N  N   . LEU B 1 109 ? -24.98892 -15.12765 53.97820 1.000 19.95095  ? 105 LEU B N   1 
ATOM   1879 C  CA  . LEU B 1 109 ? -24.99178 -14.55659 52.63507 1.000 21.84166  ? 105 LEU B CA  1 
ATOM   1880 C  C   . LEU B 1 109 ? -26.20536 -13.66065 52.42185 1.000 31.76424  ? 105 LEU B C   1 
ATOM   1881 O  O   . LEU B 1 109 ? -26.09275 -12.58164 51.82823 1.000 30.68774  ? 105 LEU B O   1 
ATOM   1882 C  CB  . LEU B 1 109 ? -24.95933 -15.67282 51.59062 1.000 25.07288  ? 105 LEU B CB  1 
ATOM   1883 C  CG  . LEU B 1 109 ? -24.74315 -15.26958 50.12805 1.000 34.87614  ? 105 LEU B CG  1 
ATOM   1884 C  CD1 . LEU B 1 109 ? -23.78508 -14.09617 50.01084 1.000 31.46354  ? 105 LEU B CD1 1 
ATOM   1885 C  CD2 . LEU B 1 109 ? -24.24697 -16.45006 49.30466 1.000 44.54743  ? 105 LEU B CD2 1 
ATOM   1886 N  N   . ARG B 1 110 ? -27.37506 -14.09282 52.90168 1.000 17.92828  ? 106 ARG B N   1 
ATOM   1887 C  CA  . ARG B 1 110 ? -28.57942 -13.27721 52.77874 1.000 34.82355  ? 106 ARG B CA  1 
ATOM   1888 C  C   . ARG B 1 110 ? -28.40360 -11.92599 53.46069 1.000 26.24137  ? 106 ARG B C   1 
ATOM   1889 O  O   . ARG B 1 110 ? -28.80136 -10.88989 52.91492 1.000 27.27266  ? 106 ARG B O   1 
ATOM   1890 C  CB  . ARG B 1 110 ? -29.77533 -14.02543 53.37001 1.000 32.19156  ? 106 ARG B CB  1 
ATOM   1891 C  CG  . ARG B 1 110 ? -30.91608 -13.13067 53.82780 1.000 33.40375  ? 106 ARG B CG  1 
ATOM   1892 C  CD  . ARG B 1 110 ? -31.67709 -12.55787 52.64540 1.000 42.13611  ? 106 ARG B CD  1 
ATOM   1893 N  NE  . ARG B 1 110 ? -32.57932 -13.54162 52.05938 1.000 46.59814  ? 106 ARG B NE  1 
ATOM   1894 C  CZ  . ARG B 1 110 ? -33.46245 -13.27471 51.10723 1.000 46.96912  ? 106 ARG B CZ  1 
ATOM   1895 N  NH1 . ARG B 1 110 ? -33.58329 -12.05987 50.59685 1.000 52.87136  ? 106 ARG B NH1 1 
ATOM   1896 N  NH2 . ARG B 1 110 ? -34.24687 -14.25025 50.65776 1.000 37.81287  ? 106 ARG B NH2 1 
ATOM   1897 N  N   . HIS B 1 111 ? -27.80007 -11.91713 54.65202 1.000 27.41313  ? 107 HIS B N   1 
ATOM   1898 C  CA  . HIS B 1 111 ? -27.63336 -10.66937 55.39026 1.000 27.83612  ? 107 HIS B CA  1 
ATOM   1899 C  C   . HIS B 1 111 ? -26.74765 -9.69104  54.63211 1.000 28.91052  ? 107 HIS B C   1 
ATOM   1900 O  O   . HIS B 1 111 ? -27.02273 -8.48552  54.60566 1.000 30.82143  ? 107 HIS B O   1 
ATOM   1901 C  CB  . HIS B 1 111 ? -27.05676 -10.95624 56.77507 1.000 31.60629  ? 107 HIS B CB  1 
ATOM   1902 C  CG  . HIS B 1 111 ? -27.95888 -11.77743 57.64193 1.000 36.97913  ? 107 HIS B CG  1 
ATOM   1903 N  ND1 . HIS B 1 111 ? -27.48394 -12.70073 58.54775 1.000 28.58739  ? 107 HIS B ND1 1 
ATOM   1904 C  CD2 . HIS B 1 111 ? -29.30902 -11.81752 57.73728 1.000 38.75967  ? 107 HIS B CD2 1 
ATOM   1905 C  CE1 . HIS B 1 111 ? -28.50179 -13.27218 59.16633 1.000 31.36259  ? 107 HIS B CE1 1 
ATOM   1906 N  NE2 . HIS B 1 111 ? -29.62062 -12.75388 58.69312 1.000 34.15907  ? 107 HIS B NE2 1 
ATOM   1907 N  N   . VAL B 1 112 ? -25.67854 -10.19068 54.00940 1.000 28.60899  ? 108 VAL B N   1 
ATOM   1908 C  CA  . VAL B 1 112 ? -24.81101 -9.32136  53.22085 1.000 31.75698  ? 108 VAL B CA  1 
ATOM   1909 C  C   . VAL B 1 112 ? -25.57470 -8.73928  52.03894 1.000 36.74782  ? 108 VAL B C   1 
ATOM   1910 O  O   . VAL B 1 112 ? -25.46539 -7.54321  51.73951 1.000 40.63161  ? 108 VAL B O   1 
ATOM   1911 C  CB  . VAL B 1 112 ? -23.55442 -10.08634 52.76684 1.000 30.84207  ? 108 VAL B CB  1 
ATOM   1912 C  CG1 . VAL B 1 112 ? -22.70175 -9.21573  51.85268 1.000 31.63985  ? 108 VAL B CG1 1 
ATOM   1913 C  CG2 . VAL B 1 112 ? -22.75162 -10.54307 53.97591 1.000 27.82203  ? 108 VAL B CG2 1 
HETATM 1914 N  N   . MSE B 1 113 ? -26.36664 -9.56375  51.35848 1.000 32.34621  ? 109 MSE B N   1 
HETATM 1915 C  CA  . MSE B 1 113 ? -27.15749 -9.07603  50.23644 1.000 35.44352  ? 109 MSE B CA  1 
HETATM 1916 C  C   . MSE B 1 113 ? -28.20161 -8.06237  50.69320 1.000 35.28956  ? 109 MSE B C   1 
HETATM 1917 O  O   . MSE B 1 113 ? -28.46237 -7.07833  50.00237 1.000 36.71057  ? 109 MSE B O   1 
HETATM 1918 C  CB  . MSE B 1 113 ? -27.83764 -10.23270 49.50109 1.000 39.98612  ? 109 MSE B CB  1 
HETATM 1919 C  CG  . MSE B 1 113 ? -26.88746 -11.30347 49.00576 1.000 31.07497  ? 109 MSE B CG  1 
HETATM 1920 SE SE  . MSE B 1 113 ? -25.60826 -10.51319 47.77237 1.000 53.29588  ? 109 MSE B SE  1 
HETATM 1921 C  CE  . MSE B 1 113 ? -26.39003 -11.09096 46.08685 1.000 53.74390  ? 109 MSE B CE  1 
ATOM   1922 N  N   . THR B 1 114 ? -28.78694 -8.30241  51.86983 1.000 28.62335  ? 110 THR B N   1 
ATOM   1923 C  CA  . THR B 1 114 ? -29.79294 -7.38229  52.39235 1.000 29.81745  ? 110 THR B CA  1 
ATOM   1924 C  C   . THR B 1 114 ? -29.17564 -6.03345  52.74730 1.000 40.39278  ? 110 THR B C   1 
ATOM   1925 O  O   . THR B 1 114 ? -29.79293 -4.98458  52.52465 1.000 36.89369  ? 110 THR B O   1 
ATOM   1926 C  CB  . THR B 1 114 ? -30.49091 -7.99631  53.60659 1.000 35.34750  ? 110 THR B CB  1 
ATOM   1927 O  OG1 . THR B 1 114 ? -31.03678 -9.27066  53.24656 1.000 28.81674  ? 110 THR B OG1 1 
ATOM   1928 C  CG2 . THR B 1 114 ? -31.62277 -7.09818  54.08026 1.000 35.80925  ? 110 THR B CG2 1 
ATOM   1929 N  N   . ASN B 1 115 ? -27.95615 -6.03596  53.29438 1.000 37.43912  ? 111 ASN B N   1 
ATOM   1930 C  CA  . ASN B 1 115 ? -27.26129 -4.77678  53.53683 1.000 41.62867  ? 111 ASN B CA  1 
ATOM   1931 C  C   . ASN B 1 115 ? -26.82644 -4.10570  52.24297 1.000 35.61955  ? 111 ASN B C   1 
ATOM   1932 O  O   . ASN B 1 115 ? -26.53831 -2.90430  52.24653 1.000 36.69092  ? 111 ASN B O   1 
ATOM   1933 C  CB  . ASN B 1 115 ? -26.04671 -4.99584  54.43819 1.000 38.50756  ? 111 ASN B CB  1 
ATOM   1934 C  CG  . ASN B 1 115 ? -25.81736 -3.83797  55.39000 1.000 42.51455  ? 111 ASN B CG  1 
ATOM   1935 O  OD1 . ASN B 1 115 ? -26.71996 -3.43850  56.12627 1.000 33.65434  ? 111 ASN B OD1 1 
ATOM   1936 N  ND2 . ASN B 1 115 ? -24.60858 -3.28939  55.37676 1.000 37.76324  ? 111 ASN B ND2 1 
ATOM   1937 N  N   . LEU B 1 116 ? -26.77269 -4.85074  51.14411 1.000 35.36639  ? 112 LEU B N   1 
ATOM   1938 C  CA  . LEU B 1 116 ? -26.49049 -4.28855  49.83230 1.000 34.60189  ? 112 LEU B CA  1 
ATOM   1939 C  C   . LEU B 1 116 ? -27.74849 -3.78897  49.13136 1.000 40.11265  ? 112 LEU B C   1 
ATOM   1940 O  O   . LEU B 1 116 ? -27.65978 -3.29787  48.00129 1.000 38.45808  ? 112 LEU B O   1 
ATOM   1941 C  CB  . LEU B 1 116 ? -25.77383 -5.32829  48.96078 1.000 35.56439  ? 112 LEU B CB  1 
ATOM   1942 C  CG  . LEU B 1 116 ? -24.24182 -5.42124  49.02965 1.000 44.99118  ? 112 LEU B CG  1 
ATOM   1943 C  CD1 . LEU B 1 116 ? -23.68939 -5.17249  50.43010 1.000 48.20467  ? 112 LEU B CD1 1 
ATOM   1944 C  CD2 . LEU B 1 116 ? -23.78459 -6.77957  48.52176 1.000 40.40445  ? 112 LEU B CD2 1 
ATOM   1945 N  N   . GLY B 1 117 ? -28.90830 -3.89137  49.77804 1.000 44.17270  ? 113 GLY B N   1 
ATOM   1946 C  CA  . GLY B 1 117 ? -30.14730 -3.42770  49.18551 1.000 45.23463  ? 113 GLY B CA  1 
ATOM   1947 C  C   . GLY B 1 117 ? -30.71523 -4.34331  48.12797 1.000 47.63256  ? 113 GLY B C   1 
ATOM   1948 O  O   . GLY B 1 117 ? -31.42851 -3.87879  47.23243 1.000 60.64761  ? 113 GLY B O   1 
ATOM   1949 N  N   . GLU B 1 118 ? -30.42932 -5.63829  48.20922 1.000 38.60547  ? 114 GLU B N   1 
ATOM   1950 C  CA  . GLU B 1 118 ? -30.79906 -6.58829  47.17041 1.000 47.04848  ? 114 GLU B CA  1 
ATOM   1951 C  C   . GLU B 1 118 ? -32.05547 -7.35134  47.56630 1.000 48.75033  ? 114 GLU B C   1 
ATOM   1952 O  O   . GLU B 1 118 ? -32.12196 -7.93231  48.65472 1.000 39.78382  ? 114 GLU B O   1 
ATOM   1953 C  CB  . GLU B 1 118 ? -29.65403 -7.56406  46.89715 1.000 43.80745  ? 114 GLU B CB  1 
ATOM   1954 C  CG  . GLU B 1 118 ? -29.53512 -7.95959  45.43893 1.000 56.85227  ? 114 GLU B CG  1 
ATOM   1955 C  CD  . GLU B 1 118 ? -28.70713 -6.97762  44.63722 1.000 63.89938  ? 114 GLU B CD  1 
ATOM   1956 O  OE1 . GLU B 1 118 ? -28.22100 -5.98870  45.22552 1.000 57.89702  ? 114 GLU B OE1 1 
ATOM   1957 O  OE2 . GLU B 1 118 ? -28.55201 -7.19008  43.41658 1.000 67.96903  ? 114 GLU B OE2 1 
ATOM   1958 N  N   . LYS B 1 119 ? -33.04661 -7.34138  46.67833 1.000 53.54412  ? 115 LYS B N   1 
ATOM   1959 C  CA  . LYS B 1 119 ? -34.25595 -8.14778  46.82739 1.000 51.64421  ? 115 LYS B CA  1 
ATOM   1960 C  C   . LYS B 1 119 ? -33.96240 -9.50542  46.20079 1.000 47.44771  ? 115 LYS B C   1 
ATOM   1961 O  O   . LYS B 1 119 ? -33.91003 -9.64227  44.97592 1.000 52.45572  ? 115 LYS B O   1 
ATOM   1962 C  CB  . LYS B 1 119 ? -35.44837 -7.44871  46.17806 1.000 53.89393  ? 115 LYS B CB  1 
ATOM   1963 C  CG  . LYS B 1 119 ? -36.62980 -8.33707  45.76307 1.000 57.95177  ? 115 LYS B CG  1 
ATOM   1964 C  CD  . LYS B 1 119 ? -37.12389 -9.25781  46.87370 1.000 57.54050  ? 115 LYS B CD  1 
ATOM   1965 C  CE  . LYS B 1 119 ? -37.97024 -10.38778 46.30192 1.000 48.66344  ? 115 LYS B CE  1 
ATOM   1966 N  NZ  . LYS B 1 119 ? -37.27961 -11.09345 45.18460 1.000 51.08920  ? 115 LYS B NZ  1 
ATOM   1967 N  N   . LEU B 1 120 ? -33.75052 -10.50979 47.04557 1.000 50.35617  ? 116 LEU B N   1 
ATOM   1968 C  CA  . LEU B 1 120 ? -33.43934 -11.85735 46.59709 1.000 46.28781  ? 116 LEU B CA  1 
ATOM   1969 C  C   . LEU B 1 120 ? -34.35358 -12.85088 47.29109 1.000 41.04098  ? 116 LEU B C   1 
ATOM   1970 O  O   . LEU B 1 120 ? -34.72655 -12.65928 48.45199 1.000 43.86447  ? 116 LEU B O   1 
ATOM   1971 C  CB  . LEU B 1 120 ? -31.98538 -12.23127 46.89234 1.000 50.63862  ? 116 LEU B CB  1 
ATOM   1972 C  CG  . LEU B 1 120 ? -30.89966 -11.85065 45.88954 1.000 41.08439  ? 116 LEU B CG  1 
ATOM   1973 C  CD1 . LEU B 1 120 ? -29.64685 -12.65386 46.19655 1.000 45.77056  ? 116 LEU B CD1 1 
ATOM   1974 C  CD2 . LEU B 1 120 ? -31.36383 -12.07296 44.45563 1.000 52.39075  ? 116 LEU B CD2 1 
ATOM   1975 N  N   . THR B 1 121 ? -34.70203 -13.91651 46.58057 1.000 43.49648  ? 117 THR B N   1 
ATOM   1976 C  CA  . THR B 1 121 ? -35.43313 -15.00270 47.20642 1.000 42.61527  ? 117 THR B CA  1 
ATOM   1977 C  C   . THR B 1 121 ? -34.46620 -15.93042 47.93567 1.000 46.28042  ? 117 THR B C   1 
ATOM   1978 O  O   . THR B 1 121 ? -33.26273 -15.95756 47.66138 1.000 41.81276  ? 117 THR B O   1 
ATOM   1979 C  CB  . THR B 1 121 ? -36.23140 -15.79180 46.16839 1.000 46.75007  ? 117 THR B CB  1 
ATOM   1980 O  OG1 . THR B 1 121 ? -35.32963 -16.44425 45.26587 1.000 35.67335  ? 117 THR B OG1 1 
ATOM   1981 C  CG2 . THR B 1 121 ? -37.14009 -14.86104 45.37907 1.000 49.68993  ? 117 THR B CG2 1 
ATOM   1982 N  N   . ASP B 1 122 ? -35.00991 -16.69159 48.88862 1.000 44.92050  ? 118 ASP B N   1 
ATOM   1983 C  CA  . ASP B 1 122 ? -34.19652 -17.68206 49.58504 1.000 48.02377  ? 118 ASP B CA  1 
ATOM   1984 C  C   . ASP B 1 122 ? -33.63946 -18.71845 48.62154 1.000 47.76907  ? 118 ASP B C   1 
ATOM   1985 O  O   . ASP B 1 122 ? -32.53074 -19.22660 48.82740 1.000 43.10130  ? 118 ASP B O   1 
ATOM   1986 C  CB  . ASP B 1 122 ? -35.01440 -18.36426 50.68004 1.000 44.98892  ? 118 ASP B CB  1 
ATOM   1987 C  CG  . ASP B 1 122 ? -35.28859 -17.45146 51.85480 1.000 55.61033  ? 118 ASP B CG  1 
ATOM   1988 O  OD1 . ASP B 1 122 ? -35.58473 -16.25847 51.63021 1.000 49.24481  ? 118 ASP B OD1 1 
ATOM   1989 O  OD2 . ASP B 1 122 ? -35.20201 -17.92907 53.00505 1.000 59.32941  ? 118 ASP B OD2 1 
ATOM   1990 N  N   . GLU B 1 123 ? -34.38717 -19.03687 47.56365 1.000 41.53271  ? 119 GLU B N   1 
ATOM   1991 C  CA  . GLU B 1 123 ? -33.89905 -19.98387 46.56810 1.000 46.53132  ? 119 GLU B CA  1 
ATOM   1992 C  C   . GLU B 1 123 ? -32.67798 -19.43244 45.84269 1.000 39.99349  ? 119 GLU B C   1 
ATOM   1993 O  O   . GLU B 1 123 ? -31.65864 -20.11954 45.71363 1.000 41.14388  ? 119 GLU B O   1 
ATOM   1994 C  CB  . GLU B 1 123 ? -35.01420 -20.32296 45.57882 1.000 49.88841  ? 119 GLU B CB  1 
ATOM   1995 C  CG  . GLU B 1 123 ? -35.97595 -21.38790 46.07826 1.000 54.26582  ? 119 GLU B CG  1 
ATOM   1996 C  CD  . GLU B 1 123 ? -36.83610 -20.90784 47.23133 1.000 55.78303  ? 119 GLU B CD  1 
ATOM   1997 O  OE1 . GLU B 1 123 ? -37.01638 -21.67777 48.19779 1.000 54.69473  ? 119 GLU B OE1 1 
ATOM   1998 O  OE2 . GLU B 1 123 ? -37.32877 -19.76110 47.17409 1.000 61.56927  ? 119 GLU B OE2 1 
ATOM   1999 N  N   . GLU B 1 124 ? -32.76063 -18.18518 45.36573 1.000 39.67822  ? 120 GLU B N   1 
ATOM   2000 C  CA  . GLU B 1 124 ? -31.61259 -17.57319 44.70177 1.000 39.30033  ? 120 GLU B CA  1 
ATOM   2001 C  C   . GLU B 1 124 ? -30.40085 -17.50593 45.62192 1.000 35.43647  ? 120 GLU B C   1 
ATOM   2002 O  O   . GLU B 1 124 ? -29.26177 -17.62337 45.15585 1.000 29.91230  ? 120 GLU B O   1 
ATOM   2003 C  CB  . GLU B 1 124 ? -31.96813 -16.17370 44.19937 1.000 42.45089  ? 120 GLU B CB  1 
ATOM   2004 C  CG  . GLU B 1 124 ? -33.02412 -16.14776 43.10725 1.000 43.66762  ? 120 GLU B CG  1 
ATOM   2005 C  CD  . GLU B 1 124 ? -33.65128 -14.77733 42.93427 1.000 45.53508  ? 120 GLU B CD  1 
ATOM   2006 O  OE1 . GLU B 1 124 ? -34.12723 -14.20271 43.93703 1.000 38.95784  ? 120 GLU B OE1 1 
ATOM   2007 O  OE2 . GLU B 1 124 ? -33.66583 -14.27348 41.79175 1.000 52.76099  ? 120 GLU B OE2 1 
ATOM   2008 N  N   . VAL B 1 125 ? -30.62082 -17.31638 46.92475 1.000 37.72658  ? 121 VAL B N   1 
ATOM   2009 C  CA  . VAL B 1 125 ? -29.50962 -17.34723 47.86957 1.000 33.02723  ? 121 VAL B CA  1 
ATOM   2010 C  C   . VAL B 1 125 ? -28.92689 -18.75211 47.95678 1.000 31.61605  ? 121 VAL B C   1 
ATOM   2011 O  O   . VAL B 1 125 ? -27.70333 -18.93045 47.99102 1.000 31.96013  ? 121 VAL B O   1 
ATOM   2012 C  CB  . VAL B 1 125 ? -29.96538 -16.83124 49.24648 1.000 41.13670  ? 121 VAL B CB  1 
ATOM   2013 C  CG1 . VAL B 1 125 ? -28.87012 -17.03546 50.28463 1.000 31.43325  ? 121 VAL B CG1 1 
ATOM   2014 C  CG2 . VAL B 1 125 ? -30.35592 -15.36316 49.15921 1.000 31.70845  ? 121 VAL B CG2 1 
ATOM   2015 N  N   . ASP B 1 126 ? -29.79029 -19.77110 47.98150 1.000 32.30137  ? 122 ASP B N   1 
ATOM   2016 C  CA  . ASP B 1 126 ? -29.30972 -21.14830 48.02510 1.000 34.05219  ? 122 ASP B CA  1 
ATOM   2017 C  C   . ASP B 1 126 ? -28.54679 -21.50786 46.75641 1.000 32.51374  ? 122 ASP B C   1 
ATOM   2018 O  O   . ASP B 1 126 ? -27.54693 -22.23409 46.81067 1.000 33.56774  ? 122 ASP B O   1 
ATOM   2019 C  CB  . ASP B 1 126 ? -30.48198 -22.10648 48.23662 1.000 39.82358  ? 122 ASP B CB  1 
ATOM   2020 C  CG  . ASP B 1 126 ? -31.00840 -22.07679 49.65638 1.000 44.03216  ? 122 ASP B CG  1 
ATOM   2021 O  OD1 . ASP B 1 126 ? -30.19599 -21.89342 50.58678 1.000 43.33310  ? 122 ASP B OD1 1 
ATOM   2022 O  OD2 . ASP B 1 126 ? -32.23323 -22.23634 49.84180 1.000 37.74468  ? 122 ASP B OD2 1 
ATOM   2023 N  N   . GLU B 1 127 ? -29.00456 -21.01011 45.60279 1.000 33.60104  ? 123 GLU B N   1 
ATOM   2024 C  CA  . GLU B 1 127 ? -28.30588 -21.28451 44.35101 1.000 32.65114  ? 123 GLU B CA  1 
ATOM   2025 C  C   . GLU B 1 127 ? -26.90400 -20.69094 44.35184 1.000 28.78396  ? 123 GLU B C   1 
ATOM   2026 O  O   . GLU B 1 127 ? -25.98092 -21.28035 43.77593 1.000 30.21355  ? 123 GLU B O   1 
ATOM   2027 C  CB  . GLU B 1 127 ? -29.10707 -20.74553 43.16382 1.000 38.76999  ? 123 GLU B CB  1 
ATOM   2028 C  CG  . GLU B 1 127 ? -30.55630 -21.21075 43.10960 1.000 42.88078  ? 123 GLU B CG  1 
ATOM   2029 C  CD  . GLU B 1 127 ? -30.76422 -22.39045 42.18249 1.000 62.20289  ? 123 GLU B CD  1 
ATOM   2030 O  OE1 . GLU B 1 127 ? -29.76565 -23.05121 41.82821 1.000 63.91943  ? 123 GLU B OE1 1 
ATOM   2031 O  OE2 . GLU B 1 127 ? -31.92698 -22.65814 41.81044 1.000 53.01373  ? 123 GLU B OE2 1 
HETATM 2032 N  N   . MSE B 1 128 ? -26.72491 -19.53291 44.98369 1.000 28.42269  ? 124 MSE B N   1 
HETATM 2033 C  CA  . MSE B 1 128 ? -25.40292 -18.92459 45.10500 1.000 29.12529  ? 124 MSE B CA  1 
HETATM 2034 C  C   . MSE B 1 128 ? -24.49831 -19.75289 46.00425 1.000 27.63052  ? 124 MSE B C   1 
HETATM 2035 O  O   . MSE B 1 128 ? -23.30897 -19.90974 45.72744 1.000 26.50242  ? 124 MSE B O   1 
HETATM 2036 C  CB  . MSE B 1 128 ? -25.49926 -17.49797 45.64885 1.000 29.15012  ? 124 MSE B CB  1 
HETATM 2037 C  CG  . MSE B 1 128 ? -26.26781 -16.53617 44.76533 1.000 35.63558  ? 124 MSE B CG  1 
HETATM 2038 SE SE  . MSE B 1 128 ? -26.48243 -14.80231 45.62509 1.000 49.68285  ? 124 MSE B SE  1 
HETATM 2039 C  CE  . MSE B 1 128 ? -24.72080 -14.08720 45.19789 1.000 39.02326  ? 124 MSE B CE  1 
ATOM   2040 N  N   . ILE B 1 129 ? -25.07112 -20.26818 47.09430 1.000 32.69153  ? 125 ILE B N   1 
ATOM   2041 C  CA  . ILE B 1 129 ? -24.32966 -21.17705 47.96300 1.000 26.62144  ? 125 ILE B CA  1 
ATOM   2042 C  C   . ILE B 1 129 ? -23.95124 -22.44044 47.20273 1.000 22.95251  ? 125 ILE B C   1 
ATOM   2043 O  O   . ILE B 1 129 ? -22.83421 -22.95513 47.33687 1.000 27.28311  ? 125 ILE B O   1 
ATOM   2044 C  CB  . ILE B 1 129 ? -25.15463 -21.49933 49.22279 1.000 24.40639  ? 125 ILE B CB  1 
ATOM   2045 C  CG1 . ILE B 1 129 ? -25.42530 -20.22635 50.02820 1.000 21.87098  ? 125 ILE B CG1 1 
ATOM   2046 C  CG2 . ILE B 1 129 ? -24.44300 -22.53148 50.08058 1.000 34.39157  ? 125 ILE B CG2 1 
ATOM   2047 C  CD1 . ILE B 1 129 ? -24.23266 -19.74353 50.82720 1.000 29.11170  ? 125 ILE B CD1 1 
ATOM   2048 N  N   . ARG B 1 130 ? -24.87129 -22.94965 46.37976 1.000 29.04488  ? 126 ARG B N   1 
ATOM   2049 C  CA  . ARG B 1 130 ? -24.61503 -24.18391 45.64474 1.000 27.75036  ? 126 ARG B CA  1 
ATOM   2050 C  C   . ARG B 1 130 ? -23.50027 -24.00325 44.62116 1.000 22.94256  ? 126 ARG B C   1 
ATOM   2051 O  O   . ARG B 1 130 ? -22.71130 -24.92616 44.38793 1.000 24.16114  ? 126 ARG B O   1 
ATOM   2052 C  CB  . ARG B 1 130 ? -25.89879 -24.66027 44.96445 1.000 25.48656  ? 126 ARG B CB  1 
ATOM   2053 C  CG  . ARG B 1 130 ? -26.62618 -25.76340 45.71628 1.000 32.20154  ? 126 ARG B CG  1 
ATOM   2054 C  CD  . ARG B 1 130 ? -27.92581 -26.14733 45.02345 1.000 33.60379  ? 126 ARG B CD  1 
ATOM   2055 N  NE  . ARG B 1 130 ? -29.08837 -25.88731 45.86481 1.000 47.76985  ? 126 ARG B NE  1 
ATOM   2056 C  CZ  . ARG B 1 130 ? -30.14113 -25.17286 45.49057 1.000 52.14519  ? 126 ARG B CZ  1 
ATOM   2057 N  NH1 . ARG B 1 130 ? -30.22175 -24.64181 44.28195 1.000 50.98599  ? 126 ARG B NH1 1 
ATOM   2058 N  NH2 . ARG B 1 130 ? -31.13815 -24.98642 46.35092 1.000 49.94171  ? 126 ARG B NH2 1 
ATOM   2059 N  N   . GLU B 1 131 ? -23.41827 -22.82440 43.99877 1.000 22.85006  ? 127 GLU B N   1 
ATOM   2060 C  CA  . GLU B 1 131 ? -22.37029 -22.58885 43.01016 1.000 32.38564  ? 127 GLU B CA  1 
ATOM   2061 C  C   . GLU B 1 131 ? -20.99529 -22.52523 43.66262 1.000 24.16144  ? 127 GLU B C   1 
ATOM   2062 O  O   . GLU B 1 131 ? -20.01371 -23.02961 43.10400 1.000 34.94864  ? 127 GLU B O   1 
ATOM   2063 C  CB  . GLU B 1 131 ? -22.65205 -21.30238 42.23320 1.000 33.55516  ? 127 GLU B CB  1 
ATOM   2064 C  CG  . GLU B 1 131 ? -21.78462 -21.14130 40.99270 1.000 44.18738  ? 127 GLU B CG  1 
ATOM   2065 C  CD  . GLU B 1 131 ? -22.24216 -20.01157 40.09217 1.000 58.20558  ? 127 GLU B CD  1 
ATOM   2066 O  OE1 . GLU B 1 131 ? -22.38464 -20.24340 38.87272 1.000 83.66061  ? 127 GLU B OE1 1 
ATOM   2067 O  OE2 . GLU B 1 131 ? -22.45754 -18.89158 40.60176 1.000 64.86682  ? 127 GLU B OE2 1 
ATOM   2068 N  N   . ALA B 1 132 ? -20.90467 -21.90871 44.84309 1.000 25.97793  ? 128 ALA B N   1 
ATOM   2069 C  CA  . ALA B 1 132 ? -19.62975 -21.78307 45.53752 1.000 27.02647  ? 128 ALA B CA  1 
ATOM   2070 C  C   . ALA B 1 132 ? -19.25670 -23.03410 46.32141 1.000 26.17318  ? 128 ALA B C   1 
ATOM   2071 O  O   . ALA B 1 132 ? -18.06732 -23.26336 46.56391 1.000 21.69753  ? 128 ALA B O   1 
ATOM   2072 C  CB  . ALA B 1 132 ? -19.66255 -20.57827 46.48120 1.000 17.73097  ? 128 ALA B CB  1 
ATOM   2073 N  N   . ASP B 1 133 ? -20.23584 -23.84090 46.72201 1.000 26.67130  ? 129 ASP B N   1 
ATOM   2074 C  CA  . ASP B 1 133 ? -19.95264 -25.02945 47.51456 1.000 20.03084  ? 129 ASP B CA  1 
ATOM   2075 C  C   . ASP B 1 133 ? -19.25052 -26.07654 46.65891 1.000 25.16377  ? 129 ASP B C   1 
ATOM   2076 O  O   . ASP B 1 133 ? -19.67594 -26.36493 45.53609 1.000 31.44588  ? 129 ASP B O   1 
ATOM   2077 C  CB  . ASP B 1 133 ? -21.24849 -25.58995 48.09871 1.000 19.48547  ? 129 ASP B CB  1 
ATOM   2078 C  CG  . ASP B 1 133 ? -21.00655 -26.65635 49.14637 1.000 24.53106  ? 129 ASP B CG  1 
ATOM   2079 O  OD1 . ASP B 1 133 ? -19.83091 -26.92937 49.46831 1.000 27.91859  ? 129 ASP B OD1 1 
ATOM   2080 O  OD2 . ASP B 1 133 ? -21.99800 -27.21683 49.65791 1.000 29.99286  ? 129 ASP B OD2 1 
ATOM   2081 N  N   . ILE B 1 134 ? -18.16854 -26.63980 47.18794 1.000 22.38391  ? 130 ILE B N   1 
ATOM   2082 C  CA  . ILE B 1 134 ? -17.39043 -27.66210 46.49968 1.000 31.00612  ? 130 ILE B CA  1 
ATOM   2083 C  C   . ILE B 1 134 ? -17.53448 -29.02245 47.17376 1.000 28.28014  ? 130 ILE B C   1 
ATOM   2084 O  O   . ILE B 1 134 ? -17.78638 -30.02771 46.50969 1.000 21.69462  ? 130 ILE B O   1 
ATOM   2085 C  CB  . ILE B 1 134 ? -15.90449 -27.25315 46.39311 1.000 29.82226  ? 130 ILE B CB  1 
ATOM   2086 C  CG1 . ILE B 1 134 ? -15.76857 -25.91864 45.66020 1.000 34.10649  ? 130 ILE B CG1 1 
ATOM   2087 C  CG2 . ILE B 1 134 ? -15.10210 -28.33981 45.68609 1.000 31.20144  ? 130 ILE B CG2 1 
ATOM   2088 C  CD1 . ILE B 1 134 ? -14.33499 -25.47225 45.47479 1.000 37.13766  ? 130 ILE B CD1 1 
ATOM   2089 N  N   . ASP B 1 135 ? -17.37298 -29.07380 48.49774 1.000 26.19374  ? 131 ASP B N   1 
ATOM   2090 C  CA  . ASP B 1 135 ? -17.44599 -30.34901 49.20064 1.000 23.29065  ? 131 ASP B CA  1 
ATOM   2091 C  C   . ASP B 1 135 ? -18.87603 -30.83595 49.39674 1.000 29.38268  ? 131 ASP B C   1 
ATOM   2092 O  O   . ASP B 1 135 ? -19.08544 -32.03840 49.59263 1.000 29.17875  ? 131 ASP B O   1 
ATOM   2093 C  CB  . ASP B 1 135 ? -16.73651 -30.25042 50.55395 1.000 27.11166  ? 131 ASP B CB  1 
ATOM   2094 C  CG  . ASP B 1 135 ? -17.14930 -29.02466 51.34523 1.000 26.48972  ? 131 ASP B CG  1 
ATOM   2095 O  OD1 . ASP B 1 135 ? -18.33001 -28.62928 51.26740 1.000 24.47053  ? 131 ASP B OD1 1 
ATOM   2096 O  OD2 . ASP B 1 135 ? -16.28920 -28.45232 52.04674 1.000 23.17343  ? 131 ASP B OD2 1 
ATOM   2097 N  N   . GLY B 1 136 ? -19.85713 -29.93985 49.35008 1.000 31.23526  ? 132 GLY B N   1 
ATOM   2098 C  CA  . GLY B 1 136 ? -21.24609 -30.32732 49.46473 1.000 16.29247  ? 132 GLY B CA  1 
ATOM   2099 C  C   . GLY B 1 136 ? -21.83809 -30.24720 50.85211 1.000 20.36524  ? 132 GLY B C   1 
ATOM   2100 O  O   . GLY B 1 136 ? -22.91416 -30.81238 51.07770 1.000 20.69178  ? 132 GLY B O   1 
ATOM   2101 N  N   . ASP B 1 137 ? -21.18048 -29.56715 51.78926 1.000 18.50469  ? 133 ASP B N   1 
ATOM   2102 C  CA  . ASP B 1 137 ? -21.71459 -29.44308 53.13948 1.000 17.48994  ? 133 ASP B CA  1 
ATOM   2103 C  C   . ASP B 1 137 ? -22.79191 -28.37229 53.25831 1.000 20.16270  ? 133 ASP B C   1 
ATOM   2104 O  O   . ASP B 1 137 ? -23.31446 -28.16296 54.35774 1.000 21.43936  ? 133 ASP B O   1 
ATOM   2105 C  CB  . ASP B 1 137 ? -20.58239 -29.15864 54.13253 1.000 21.74873  ? 133 ASP B CB  1 
ATOM   2106 C  CG  . ASP B 1 137 ? -19.92145 -27.81056 53.90598 1.000 20.12306  ? 133 ASP B CG  1 
ATOM   2107 O  OD1 . ASP B 1 137 ? -20.14946 -27.19235 52.84513 1.000 24.16846  ? 133 ASP B OD1 1 
ATOM   2108 O  OD2 . ASP B 1 137 ? -19.16420 -27.36970 54.79535 1.000 19.46426  ? 133 ASP B OD2 1 
ATOM   2109 N  N   . GLY B 1 138 ? -23.13926 -27.69904 52.16496 1.000 17.68603  ? 134 GLY B N   1 
ATOM   2110 C  CA  . GLY B 1 138 ? -24.13141 -26.64633 52.20947 1.000 27.23422  ? 134 GLY B CA  1 
ATOM   2111 C  C   . GLY B 1 138 ? -23.62382 -25.31064 52.69801 1.000 22.21822  ? 134 GLY B C   1 
ATOM   2112 O  O   . GLY B 1 138 ? -24.43271 -24.40199 52.91682 1.000 23.89366  ? 134 GLY B O   1 
ATOM   2113 N  N   . GLN B 1 139 ? -22.31349 -25.16255 52.88166 1.000 20.75682  ? 135 GLN B N   1 
ATOM   2114 C  CA  . GLN B 1 139 ? -21.71832 -23.91933 53.34619 1.000 20.35051  ? 135 GLN B CA  1 
ATOM   2115 C  C   . GLN B 1 139 ? -20.48434 -23.62280 52.50563 1.000 24.51388  ? 135 GLN B C   1 
ATOM   2116 O  O   . GLN B 1 139 ? -20.00919 -24.46649 51.74134 1.000 20.40022  ? 135 GLN B O   1 
ATOM   2117 C  CB  . GLN B 1 139 ? -21.35826 -23.99157 54.83703 1.000 20.76448  ? 135 GLN B CB  1 
ATOM   2118 C  CG  . GLN B 1 139 ? -22.55652 -24.16432 55.76246 1.000 24.86759  ? 135 GLN B CG  1 
ATOM   2119 C  CD  . GLN B 1 139 ? -22.20177 -23.96031 57.22369 1.000 25.55784  ? 135 GLN B CD  1 
ATOM   2120 O  OE1 . GLN B 1 139 ? -22.70029 -23.04201 57.87531 1.000 19.27858  ? 135 GLN B OE1 1 
ATOM   2121 N  NE2 . GLN B 1 139 ? -21.33939 -24.82454 57.74796 1.000 18.45565  ? 135 GLN B NE2 1 
ATOM   2122 N  N   . VAL B 1 140 ? -19.96482 -22.40669 52.64967 1.000 14.60045  ? 136 VAL B N   1 
ATOM   2123 C  CA  . VAL B 1 140 ? -18.77936 -21.96250 51.92425 1.000 23.82578  ? 136 VAL B CA  1 
ATOM   2124 C  C   . VAL B 1 140 ? -17.68073 -21.67986 52.93844 1.000 18.70552  ? 136 VAL B C   1 
ATOM   2125 O  O   . VAL B 1 140 ? -17.81531 -20.77126 53.76744 1.000 19.85738  ? 136 VAL B O   1 
ATOM   2126 C  CB  . VAL B 1 140 ? -19.06104 -20.71819 51.06632 1.000 28.83886  ? 136 VAL B CB  1 
ATOM   2127 C  CG1 . VAL B 1 140 ? -17.82118 -20.33536 50.26630 1.000 14.62648  ? 136 VAL B CG1 1 
ATOM   2128 C  CG2 . VAL B 1 140 ? -20.24691 -20.96227 50.14401 1.000 17.33921  ? 136 VAL B CG2 1 
ATOM   2129 N  N   . ASN B 1 141 ? -16.59901 -22.45482 52.87603 1.000 17.25379  ? 137 ASN B N   1 
ATOM   2130 C  CA  . ASN B 1 141 ? -15.43665 -22.20337 53.71389 1.000 15.74234  ? 137 ASN B CA  1 
ATOM   2131 C  C   . ASN B 1 141 ? -14.49342 -21.24613 52.98331 1.000 19.97089  ? 137 ASN B C   1 
ATOM   2132 O  O   . ASN B 1 141 ? -14.82249 -20.70858 51.92243 1.000 17.88229  ? 137 ASN B O   1 
ATOM   2133 C  CB  . ASN B 1 141 ? -14.76706 -23.52194 54.11455 1.000 18.16824  ? 137 ASN B CB  1 
ATOM   2134 C  CG  . ASN B 1 141 ? -14.25007 -24.32297 52.92391 1.000 22.35357  ? 137 ASN B CG  1 
ATOM   2135 O  OD1 . ASN B 1 141 ? -14.01590 -23.78872 51.84088 1.000 23.53572  ? 137 ASN B OD1 1 
ATOM   2136 N  ND2 . ASN B 1 141 ? -14.06233 -25.62143 53.13282 1.000 21.28095  ? 137 ASN B ND2 1 
ATOM   2137 N  N   . TYR B 1 142 ? -13.30026 -21.02562 53.54143 1.000 21.71529  ? 138 TYR B N   1 
ATOM   2138 C  CA  . TYR B 1 142 ? -12.38316 -20.06012 52.94228 1.000 23.58982  ? 138 TYR B CA  1 
ATOM   2139 C  C   . TYR B 1 142 ? -11.85403 -20.54604 51.59848 1.000 24.14481  ? 138 TYR B C   1 
ATOM   2140 O  O   . TYR B 1 142 ? -11.77226 -19.76597 50.64238 1.000 31.30939  ? 138 TYR B O   1 
ATOM   2141 C  CB  . TYR B 1 142 ? -11.22178 -19.76249 53.88907 1.000 24.59105  ? 138 TYR B CB  1 
ATOM   2142 C  CG  . TYR B 1 142 ? -10.33737 -18.64553 53.38699 1.000 30.73496  ? 138 TYR B CG  1 
ATOM   2143 C  CD1 . TYR B 1 142 ? -10.84484 -17.36599 53.20500 1.000 31.44925  ? 138 TYR B CD1 1 
ATOM   2144 C  CD2 . TYR B 1 142 ? -9.00542  -18.87397 53.06756 1.000 35.68858  ? 138 TYR B CD2 1 
ATOM   2145 C  CE1 . TYR B 1 142 ? -10.04815 -16.34176 52.73702 1.000 36.56929  ? 138 TYR B CE1 1 
ATOM   2146 C  CE2 . TYR B 1 142 ? -8.19983  -17.85388 52.59675 1.000 34.00327  ? 138 TYR B CE2 1 
ATOM   2147 C  CZ  . TYR B 1 142 ? -8.72799  -16.58991 52.43543 1.000 30.71185  ? 138 TYR B CZ  1 
ATOM   2148 O  OH  . TYR B 1 142 ? -7.93803  -15.56795 51.96617 1.000 43.87292  ? 138 TYR B OH  1 
ATOM   2149 N  N   . GLU B 1 143 ? -11.48012 -21.82577 51.50787 1.000 25.23538  ? 139 GLU B N   1 
ATOM   2150 C  CA  . GLU B 1 143 ? -10.95370 -22.35442 50.25258 1.000 29.38658  ? 139 GLU B CA  1 
ATOM   2151 C  C   . GLU B 1 143 ? -11.97315 -22.22345 49.12823 1.000 24.41392  ? 139 GLU B C   1 
ATOM   2152 O  O   . GLU B 1 143 ? -11.61913 -21.87343 47.99645 1.000 25.77078  ? 139 GLU B O   1 
ATOM   2153 C  CB  . GLU B 1 143 ? -10.53282 -23.81365 50.43009 1.000 31.43570  ? 139 GLU B CB  1 
ATOM   2154 C  CG  . GLU B 1 143 ? -9.85557  -24.41707 49.20736 1.000 34.67155  ? 139 GLU B CG  1 
ATOM   2155 C  CD  . GLU B 1 143 ? -8.60058  -23.66703 48.79977 1.000 36.92448  ? 139 GLU B CD  1 
ATOM   2156 O  OE1 . GLU B 1 143 ? -7.72459  -23.45434 49.66449 1.000 40.96162  ? 139 GLU B OE1 1 
ATOM   2157 O  OE2 . GLU B 1 143 ? -8.48820  -23.29220 47.61300 1.000 34.38333  ? 139 GLU B OE2 1 
ATOM   2158 N  N   . GLU B 1 144 ? -13.24640 -22.49273 49.42319 1.000 22.75692  ? 140 GLU B N   1 
ATOM   2159 C  CA  . GLU B 1 144 ? -14.28772 -22.34022 48.41254 1.000 25.66033  ? 140 GLU B CA  1 
ATOM   2160 C  C   . GLU B 1 144 ? -14.54087 -20.87003 48.10083 1.000 22.70959  ? 140 GLU B C   1 
ATOM   2161 O  O   . GLU B 1 144 ? -14.80585 -20.51084 46.94778 1.000 23.07485  ? 140 GLU B O   1 
ATOM   2162 C  CB  . GLU B 1 144 ? -15.56892 -23.02794 48.88286 1.000 21.39386  ? 140 GLU B CB  1 
ATOM   2163 C  CG  . GLU B 1 144 ? -15.43851 -24.53981 48.99637 1.000 22.82173  ? 140 GLU B CG  1 
ATOM   2164 C  CD  . GLU B 1 144 ? -16.54241 -25.16239 49.82308 1.000 22.57902  ? 140 GLU B CD  1 
ATOM   2165 O  OE1 . GLU B 1 144 ? -17.15424 -24.43635 50.63162 1.000 18.96369  ? 140 GLU B OE1 1 
ATOM   2166 O  OE2 . GLU B 1 144 ? -16.79687 -26.37605 49.66685 1.000 23.99185  ? 140 GLU B OE2 1 
ATOM   2167 N  N   . PHE B 1 145 ? -14.45639 -20.00628 49.11593 1.000 28.05151  ? 141 PHE B N   1 
ATOM   2168 C  CA  . PHE B 1 145 ? -14.60380 -18.57097 48.89120 1.000 29.07109  ? 141 PHE B CA  1 
ATOM   2169 C  C   . PHE B 1 145 ? -13.47896 -18.03092 48.01659 1.000 31.75705  ? 141 PHE B C   1 
ATOM   2170 O  O   . PHE B 1 145 ? -13.71671 -17.20848 47.12382 1.000 26.57520  ? 141 PHE B O   1 
ATOM   2171 C  CB  . PHE B 1 145 ? -14.64249 -17.83876 50.23447 1.000 29.58058  ? 141 PHE B CB  1 
ATOM   2172 C  CG  . PHE B 1 145 ? -14.90733 -16.36291 50.12201 1.000 26.16984  ? 141 PHE B CG  1 
ATOM   2173 C  CD1 . PHE B 1 145 ? -16.19060 -15.89017 49.90203 1.000 25.30754  ? 141 PHE B CD1 1 
ATOM   2174 C  CD2 . PHE B 1 145 ? -13.87430 -15.44767 50.25240 1.000 26.28175  ? 141 PHE B CD2 1 
ATOM   2175 C  CE1 . PHE B 1 145 ? -16.43868 -14.53209 49.80321 1.000 35.54691  ? 141 PHE B CE1 1 
ATOM   2176 C  CE2 . PHE B 1 145 ? -14.11512 -14.08744 50.15539 1.000 29.78885  ? 141 PHE B CE2 1 
ATOM   2177 C  CZ  . PHE B 1 145 ? -15.40051 -13.62944 49.93044 1.000 29.23915  ? 141 PHE B CZ  1 
ATOM   2178 N  N   . VAL B 1 146 ? -12.24701 -18.48908 48.25453 1.000 37.16840  ? 142 VAL B N   1 
ATOM   2179 C  CA  . VAL B 1 146 ? -11.10262 -18.01235 47.47974 1.000 30.95757  ? 142 VAL B CA  1 
ATOM   2180 C  C   . VAL B 1 146 ? -11.24733 -18.41364 46.01649 1.000 34.15059  ? 142 VAL B C   1 
ATOM   2181 O  O   . VAL B 1 146 ? -11.02833 -17.60531 45.10585 1.000 29.83365  ? 142 VAL B O   1 
ATOM   2182 C  CB  . VAL B 1 146 ? -9.78972  -18.54314 48.08392 1.000 40.02650  ? 142 VAL B CB  1 
ATOM   2183 C  CG1 . VAL B 1 146 ? -8.69499  -18.60071 47.02803 1.000 35.60838  ? 142 VAL B CG1 1 
ATOM   2184 C  CG2 . VAL B 1 146 ? -9.36139  -17.67516 49.25108 1.000 31.03571  ? 142 VAL B CG2 1 
ATOM   2185 N  N   . GLN B 1 147 ? -11.62179 -19.67212 45.76981 1.000 36.39297  ? 143 GLN B N   1 
ATOM   2186 C  CA  . GLN B 1 147 ? -11.81454 -20.13017 44.39758 1.000 35.38145  ? 143 GLN B CA  1 
ATOM   2187 C  C   . GLN B 1 147 ? -12.93768 -19.36886 43.70703 1.000 33.18497  ? 143 GLN B C   1 
ATOM   2188 O  O   . GLN B 1 147 ? -12.92798 -19.22437 42.47908 1.000 44.89917  ? 143 GLN B O   1 
ATOM   2189 C  CB  . GLN B 1 147 ? -12.09827 -21.63203 44.38508 1.000 37.12990  ? 143 GLN B CB  1 
ATOM   2190 C  CG  . GLN B 1 147 ? -10.88058 -22.48819 44.69684 1.000 36.21198  ? 143 GLN B CG  1 
ATOM   2191 C  CD  . GLN B 1 147 ? -11.13529 -23.96541 44.48162 1.000 38.73988  ? 143 GLN B CD  1 
ATOM   2192 O  OE1 . GLN B 1 147 ? -11.80323 -24.35871 43.52650 1.000 37.64855  ? 143 GLN B OE1 1 
ATOM   2193 N  NE2 . GLN B 1 147 ? -10.60237 -24.79358 45.37188 1.000 40.62739  ? 143 GLN B NE2 1 
HETATM 2194 N  N   . MSE B 1 148 ? -13.90219 -18.87144 44.47351 1.000 36.73267  ? 144 MSE B N   1 
HETATM 2195 C  CA  . MSE B 1 148 ? -15.01821 -18.11293 43.92352 1.000 35.03747  ? 144 MSE B CA  1 
HETATM 2196 C  C   . MSE B 1 148 ? -14.61348 -16.68865 43.55872 1.000 46.34065  ? 144 MSE B C   1 
HETATM 2197 O  O   . MSE B 1 148 ? -15.07391 -16.14272 42.55565 1.000 44.45348  ? 144 MSE B O   1 
HETATM 2198 C  CB  . MSE B 1 148 ? -16.17957 -18.08510 44.92021 1.000 28.85375  ? 144 MSE B CB  1 
HETATM 2199 C  CG  . MSE B 1 148 ? -17.43317 -17.40016 44.40061 1.000 41.98359  ? 144 MSE B CG  1 
HETATM 2200 SE SE  . MSE B 1 148 ? -18.57764 -18.58498 43.35916 1.000 86.70456  ? 144 MSE B SE  1 
HETATM 2201 C  CE  . MSE B 1 148 ? -18.22461 -17.86463 41.58074 1.000 45.28591  ? 144 MSE B CE  1 
HETATM 2202 N  N   . MSE B 1 149 ? -13.74474 -16.09593 44.37308 1.000 35.23306  ? 145 MSE B N   1 
HETATM 2203 C  CA  . MSE B 1 149 ? -13.39823 -14.68547 44.22603 1.000 41.63457  ? 145 MSE B CA  1 
HETATM 2204 C  C   . MSE B 1 149 ? -12.17295 -14.45516 43.34861 1.000 44.20018  ? 145 MSE B C   1 
HETATM 2205 O  O   . MSE B 1 149 ? -11.96597 -13.35550 42.83794 1.000 42.59371  ? 145 MSE B O   1 
HETATM 2206 C  CB  . MSE B 1 149 ? -13.17720 -14.05159 45.60109 1.000 33.52757  ? 145 MSE B CB  1 
HETATM 2207 C  CG  . MSE B 1 149 ? -14.39747 -14.09211 46.51541 1.000 44.96941  ? 145 MSE B CG  1 
HETATM 2208 SE SE  . MSE B 1 149 ? -15.69268 -12.65881 46.20426 1.000 57.35217  ? 145 MSE B SE  1 
HETATM 2209 C  CE  . MSE B 1 149 ? -16.49704 -13.28953 44.54730 1.000 55.39241  ? 145 MSE B CE  1 
ATOM   2210 N  N   . THR B 1 150 ? -11.36331 -15.49159 43.17931 1.000 47.00190  ? 146 THR B N   1 
ATOM   2211 C  CA  . THR B 1 150 ? -10.19426 -15.45218 42.31609 1.000 42.29868  ? 146 THR B CA  1 
ATOM   2212 C  C   . THR B 1 150 ? -10.40172 -16.39408 41.13516 1.000 51.48893  ? 146 THR B C   1 
ATOM   2213 O  O   . THR B 1 150 ? -11.45701 -17.01453 40.97795 1.000 47.50077  ? 146 THR B O   1 
ATOM   2214 C  CB  . THR B 1 150 ? -8.92990  -15.82261 43.09480 1.000 39.68880  ? 146 THR B CB  1 
ATOM   2215 O  OG1 . THR B 1 150 ? -8.84448  -17.24713 43.21841 1.000 48.03145  ? 146 THR B OG1 1 
ATOM   2216 C  CG2 . THR B 1 150 ? -8.95106  -15.19681 44.48270 1.000 48.31173  ? 146 THR B CG2 1 
ATOM   2217 N  N   . ALA B 1 151 ? -9.37491  -16.49542 40.29579 1.000 60.09816  ? 147 ALA B N   1 
ATOM   2218 C  CA  . ALA B 1 151 ? -9.36782  -17.43395 39.18340 1.000 69.98662  ? 147 ALA B CA  1 
ATOM   2219 C  C   . ALA B 1 151 ? -8.87607  -18.81593 39.59194 1.000 59.44635  ? 147 ALA B C   1 
ATOM   2220 O  O   . ALA B 1 151 ? -8.58971  -19.64274 38.71959 1.000 65.60632  ? 147 ALA B O   1 
ATOM   2221 C  CB  . ALA B 1 151 ? -8.50829  -16.89198 38.03840 1.000 57.22655  ? 147 ALA B CB  1 
ATOM   2222 N  N   . LYS B 1 152 ? -8.77091  -19.07936 40.89275 1.000 55.75420  ? 148 LYS B N   1 
ATOM   2223 C  CA  . LYS B 1 152 ? -8.31059  -20.37609 41.36662 1.000 58.39699  ? 148 LYS B CA  1 
ATOM   2224 C  C   . LYS B 1 152 ? -9.28020  -21.47509 40.94514 1.000 57.57296  ? 148 LYS B C   1 
ATOM   2225 O  O   . LYS B 1 152 ? -10.45723 -21.22265 40.67169 1.000 57.61617  ? 148 LYS B O   1 
ATOM   2226 C  CB  . LYS B 1 152 ? -8.15751  -20.35798 42.88857 1.000 56.41537  ? 148 LYS B CB  1 
ATOM   2227 C  CG  . LYS B 1 152 ? -6.92697  -21.08269 43.40763 1.000 56.02717  ? 148 LYS B CG  1 
ATOM   2228 C  CD  . LYS B 1 152 ? -7.22648  -21.79691 44.71462 1.000 52.32034  ? 148 LYS B CD  1 
ATOM   2229 C  CE  . LYS B 1 152 ? -5.97621  -22.43404 45.29443 1.000 43.67107  ? 148 LYS B CE  1 
ATOM   2230 N  NZ  . LYS B 1 152 ? -5.93191  -22.31402 46.77742 1.000 40.95561  ? 148 LYS B NZ  1 
ATOM   2231 N  N   . ASN B 1 153 ? -8.75958  -22.70198 40.89534 1.000 64.64120  ? 149 ASN B N   1 
ATOM   2232 C  CA  . ASN B 1 153 ? -9.47400  -23.90833 40.45623 1.000 59.90739  ? 149 ASN B CA  1 
ATOM   2233 C  C   . ASN B 1 153 ? -10.98121 -23.90710 40.70363 1.000 54.92999  ? 149 ASN B C   1 
ATOM   2234 O  O   . ASN B 1 153 ? -11.72875 -24.62682 40.04081 1.000 60.95952  ? 149 ASN B O   1 
ATOM   2235 C  CB  . ASN B 1 153 ? -8.86361  -25.13516 41.14080 1.000 50.53171  ? 149 ASN B CB  1 
ATOM   2236 C  CG  . ASN B 1 153 ? -8.72534  -26.32032 40.20547 1.000 57.36412  ? 149 ASN B CG  1 
ATOM   2237 O  OD1 . ASN B 1 153 ? -8.36997  -26.16857 39.03665 1.000 51.15234  ? 149 ASN B OD1 1 
ATOM   2238 N  ND2 . ASN B 1 153 ? -9.00729  -27.51247 40.71908 1.000 54.19033  ? 149 ASN B ND2 1 
ATOM   2239 N  N   . THR C 1 9   ? 5.38087   -13.18309 85.68639 1.000 59.22724  ? 5   THR C N   1 
ATOM   2240 C  CA  . THR C 1 9   ? 5.11705   -11.84148 86.19184 1.000 61.10135  ? 5   THR C CA  1 
ATOM   2241 C  C   . THR C 1 9   ? 3.62662   -11.53873 86.16333 1.000 65.13860  ? 5   THR C C   1 
ATOM   2242 O  O   . THR C 1 9   ? 2.85825   -12.23378 85.49931 1.000 68.03697  ? 5   THR C O   1 
ATOM   2243 C  CB  . THR C 1 9   ? 5.85160   -10.76600 85.36654 1.000 64.08435  ? 5   THR C CB  1 
ATOM   2244 O  OG1 . THR C 1 9   ? 5.77839   -11.09701 83.97289 1.000 65.40931  ? 5   THR C OG1 1 
ATOM   2245 C  CG2 . THR C 1 9   ? 7.31079   -10.67782 85.78218 1.000 71.00401  ? 5   THR C CG2 1 
ATOM   2246 N  N   . GLU C 1 10  ? 3.22000   -10.49281 86.88763 1.000 63.14511  ? 6   GLU C N   1 
ATOM   2247 C  CA  . GLU C 1 10  ? 1.84481   -10.01758 86.78121 1.000 61.98059  ? 6   GLU C CA  1 
ATOM   2248 C  C   . GLU C 1 10  ? 1.53135   -9.55152  85.36594 1.000 69.70574  ? 6   GLU C C   1 
ATOM   2249 O  O   . GLU C 1 10  ? 0.36506   -9.54759  84.95608 1.000 64.46115  ? 6   GLU C O   1 
ATOM   2250 C  CB  . GLU C 1 10  ? 1.59822   -8.88783  87.78242 1.000 61.97071  ? 6   GLU C CB  1 
ATOM   2251 N  N   . GLU C 1 11  ? 2.55752   -9.15890  84.60739 1.000 67.15164  ? 7   GLU C N   1 
ATOM   2252 C  CA  . GLU C 1 11  ? 2.35575   -8.77076  83.21578 1.000 68.04110  ? 7   GLU C CA  1 
ATOM   2253 C  C   . GLU C 1 11  ? 2.09375   -9.98852  82.33938 1.000 66.41415  ? 7   GLU C C   1 
ATOM   2254 O  O   . GLU C 1 11  ? 1.21236   -9.96341  81.47173 1.000 70.58477  ? 7   GLU C O   1 
ATOM   2255 C  CB  . GLU C 1 11  ? 3.57168   -7.99609  82.70743 1.000 67.81927  ? 7   GLU C CB  1 
ATOM   2256 C  CG  . GLU C 1 11  ? 3.48034   -6.49414  82.90092 1.000 70.26388  ? 7   GLU C CG  1 
ATOM   2257 C  CD  . GLU C 1 11  ? 2.30564   -5.88414  82.16216 1.000 74.09547  ? 7   GLU C CD  1 
ATOM   2258 O  OE1 . GLU C 1 11  ? 2.48184   -5.47969  80.99343 1.000 72.82256  ? 7   GLU C OE1 1 
ATOM   2259 O  OE2 . GLU C 1 11  ? 1.20656   -5.80344  82.75086 1.000 70.81383  ? 7   GLU C OE2 1 
ATOM   2260 N  N   . GLN C 1 12  ? 2.85975   -11.06284 82.54787 1.000 64.51352  ? 8   GLN C N   1 
ATOM   2261 C  CA  . GLN C 1 12  ? 2.67066   -12.27883 81.76344 1.000 61.68478  ? 8   GLN C CA  1 
ATOM   2262 C  C   . GLN C 1 12  ? 1.26116   -12.82938 81.94013 1.000 66.71986  ? 8   GLN C C   1 
ATOM   2263 O  O   . GLN C 1 12  ? 0.58692   -13.16356 80.95915 1.000 64.98455  ? 8   GLN C O   1 
ATOM   2264 C  CB  . GLN C 1 12  ? 3.71395   -13.32441 82.15939 1.000 66.51234  ? 8   GLN C CB  1 
ATOM   2265 N  N   . ILE C 1 13  ? 0.79556   -12.92149 83.18961 1.000 61.20300  ? 9   ILE C N   1 
ATOM   2266 C  CA  . ILE C 1 13  ? -0.55970  -13.40384 83.44910 1.000 61.42039  ? 9   ILE C CA  1 
ATOM   2267 C  C   . ILE C 1 13  ? -1.57949  -12.52735 82.73508 1.000 60.60582  ? 9   ILE C C   1 
ATOM   2268 O  O   . ILE C 1 13  ? -2.51579  -13.02548 82.09932 1.000 53.72186  ? 9   ILE C O   1 
ATOM   2269 C  CB  . ILE C 1 13  ? -0.83678  -13.45903 84.96225 1.000 49.50233  ? 9   ILE C CB  1 
ATOM   2270 C  CG1 . ILE C 1 13  ? 0.31152   -14.14372 85.70479 1.000 58.29356  ? 9   ILE C CG1 1 
ATOM   2271 C  CG2 . ILE C 1 13  ? -2.15618  -14.16259 85.23650 1.000 56.13986  ? 9   ILE C CG2 1 
ATOM   2272 C  CD1 . ILE C 1 13  ? 0.47205   -13.66715 87.13322 1.000 57.28292  ? 9   ILE C CD1 1 
ATOM   2273 N  N   . ALA C 1 14  ? -1.41082  -11.20485 82.83020 1.000 64.70627  ? 10  ALA C N   1 
ATOM   2274 C  CA  . ALA C 1 14  ? -2.32981  -10.28984 82.16178 1.000 62.94190  ? 10  ALA C CA  1 
ATOM   2275 C  C   . ALA C 1 14  ? -2.34086  -10.50501 80.65507 1.000 62.66751  ? 10  ALA C C   1 
ATOM   2276 O  O   . ALA C 1 14  ? -3.37181  -10.29491 80.00852 1.000 58.52953  ? 10  ALA C O   1 
ATOM   2277 C  CB  . ALA C 1 14  ? -1.96597  -8.84193  82.49246 1.000 69.86612  ? 10  ALA C CB  1 
ATOM   2278 N  N   . GLU C 1 15  ? -1.21505  -10.92904 80.07897 1.000 59.05545  ? 11  GLU C N   1 
ATOM   2279 C  CA  . GLU C 1 15  ? -1.18396  -11.21536 78.65018 1.000 58.87823  ? 11  GLU C CA  1 
ATOM   2280 C  C   . GLU C 1 15  ? -1.80736  -12.56686 78.32507 1.000 55.74987  ? 11  GLU C C   1 
ATOM   2281 O  O   . GLU C 1 15  ? -2.40285  -12.72588 77.25303 1.000 55.30193  ? 11  GLU C O   1 
ATOM   2282 C  CB  . GLU C 1 15  ? 0.25301   -11.14347 78.13514 1.000 63.92535  ? 11  GLU C CB  1 
ATOM   2283 C  CG  . GLU C 1 15  ? 0.77070   -9.71866  78.02125 1.000 65.62555  ? 11  GLU C CG  1 
ATOM   2284 C  CD  . GLU C 1 15  ? 2.27499   -9.63122  78.13127 1.000 69.72144  ? 11  GLU C CD  1 
ATOM   2285 O  OE1 . GLU C 1 15  ? 2.90760   -10.66726 78.42053 1.000 82.72537  ? 11  GLU C OE1 1 
ATOM   2286 O  OE2 . GLU C 1 15  ? 2.82351   -8.52465  77.94119 1.000 69.62993  ? 11  GLU C OE2 1 
ATOM   2287 N  N   . PHE C 1 16  ? -1.69059  -13.54302 79.22947 1.000 56.05131  ? 12  PHE C N   1 
ATOM   2288 C  CA  . PHE C 1 16  ? -2.37606  -14.81425 79.02650 1.000 55.23380  ? 12  PHE C CA  1 
ATOM   2289 C  C   . PHE C 1 16  ? -3.88572  -14.65871 79.15155 1.000 50.15580  ? 12  PHE C C   1 
ATOM   2290 O  O   . PHE C 1 16  ? -4.63848  -15.37084 78.47709 1.000 52.77808  ? 12  PHE C O   1 
ATOM   2291 C  CB  . PHE C 1 16  ? -1.86999  -15.85631 80.02335 1.000 51.30396  ? 12  PHE C CB  1 
ATOM   2292 C  CG  . PHE C 1 16  ? -0.44151  -16.26397 79.80511 1.000 60.00452  ? 12  PHE C CG  1 
ATOM   2293 C  CD1 . PHE C 1 16  ? 0.48728   -16.14856 80.82632 1.000 57.12986  ? 12  PHE C CD1 1 
ATOM   2294 C  CD2 . PHE C 1 16  ? -0.02508  -16.75828 78.58114 1.000 64.72692  ? 12  PHE C CD2 1 
ATOM   2295 C  CE1 . PHE C 1 16  ? 1.80275   -16.51972 80.63355 1.000 60.31899  ? 12  PHE C CE1 1 
ATOM   2296 C  CE2 . PHE C 1 16  ? 1.29115   -17.13237 78.38161 1.000 58.42200  ? 12  PHE C CE2 1 
ATOM   2297 C  CZ  . PHE C 1 16  ? 2.20592   -17.01239 79.41026 1.000 62.75530  ? 12  PHE C CZ  1 
ATOM   2298 N  N   . LYS C 1 17  ? -4.34310  -13.74374 80.01101 1.000 47.48427  ? 13  LYS C N   1 
ATOM   2299 C  CA  . LYS C 1 17  ? -5.77421  -13.48410 80.12851 1.000 52.55102  ? 13  LYS C CA  1 
ATOM   2300 C  C   . LYS C 1 17  ? -6.33502  -12.91687 78.83182 1.000 56.37544  ? 13  LYS C C   1 
ATOM   2301 O  O   . LYS C 1 17  ? -7.45147  -13.25981 78.42471 1.000 49.64700  ? 13  LYS C O   1 
ATOM   2302 C  CB  . LYS C 1 17  ? -6.04031  -12.52651 81.29007 1.000 55.95798  ? 13  LYS C CB  1 
ATOM   2303 C  CG  . LYS C 1 17  ? -7.50518  -12.15832 81.47683 1.000 49.89076  ? 13  LYS C CG  1 
ATOM   2304 C  CD  . LYS C 1 17  ? -8.20467  -13.12604 82.41989 1.000 53.52853  ? 13  LYS C CD  1 
ATOM   2305 C  CE  . LYS C 1 17  ? -9.71748  -13.03902 82.28888 1.000 57.53104  ? 13  LYS C CE  1 
ATOM   2306 N  NZ  . LYS C 1 17  ? -10.38660 -13.03502 83.62043 1.000 66.65594  ? 13  LYS C NZ  1 
ATOM   2307 N  N   . GLU C 1 18  ? -5.57411  -12.04321 78.16909 1.000 51.12798  ? 14  GLU C N   1 
ATOM   2308 C  CA  . GLU C 1 18  ? -6.01187  -11.51678 76.88162 1.000 59.92440  ? 14  GLU C CA  1 
ATOM   2309 C  C   . GLU C 1 18  ? -5.93372  -12.57324 75.78573 1.000 49.35664  ? 14  GLU C C   1 
ATOM   2310 O  O   . GLU C 1 18  ? -6.74290  -12.55346 74.85072 1.000 49.05707  ? 14  GLU C O   1 
ATOM   2311 C  CB  . GLU C 1 18  ? -5.18996  -10.28013 76.50963 1.000 58.52264  ? 14  GLU C CB  1 
ATOM   2312 C  CG  . GLU C 1 18  ? -5.80211  -8.95656  76.96674 1.000 62.70617  ? 14  GLU C CG  1 
ATOM   2313 C  CD  . GLU C 1 18  ? -6.34615  -8.99817  78.38246 1.000 68.24257  ? 14  GLU C CD  1 
ATOM   2314 O  OE1 . GLU C 1 18  ? -7.58183  -9.07877  78.54240 1.000 75.35261  ? 14  GLU C OE1 1 
ATOM   2315 O  OE2 . GLU C 1 18  ? -5.55160  -8.90973  79.33915 1.000 69.20779  ? 14  GLU C OE2 1 
ATOM   2316 N  N   . ALA C 1 19  ? -4.97545  -13.49907 75.87937 1.000 47.70548  ? 15  ALA C N   1 
ATOM   2317 C  CA  . ALA C 1 19  ? -4.93916  -14.61311 74.93847 1.000 49.16234  ? 15  ALA C CA  1 
ATOM   2318 C  C   . ALA C 1 19  ? -6.08893  -15.58165 75.18183 1.000 43.81545  ? 15  ALA C C   1 
ATOM   2319 O  O   . ALA C 1 19  ? -6.58664  -16.20312 74.23605 1.000 48.16998  ? 15  ALA C O   1 
ATOM   2320 C  CB  . ALA C 1 19  ? -3.59826  -15.34185 75.03289 1.000 40.56824  ? 15  ALA C CB  1 
ATOM   2321 N  N   . PHE C 1 20  ? -6.51976  -15.72052 76.43826 1.000 37.71248  ? 16  PHE C N   1 
ATOM   2322 C  CA  . PHE C 1 20  ? -7.66041  -16.57544 76.75052 1.000 43.30027  ? 16  PHE C CA  1 
ATOM   2323 C  C   . PHE C 1 20  ? -8.93878  -16.04017 76.11853 1.000 43.14515  ? 16  PHE C C   1 
ATOM   2324 O  O   . PHE C 1 20  ? -9.80345  -16.81656 75.69507 1.000 34.72988  ? 16  PHE C O   1 
ATOM   2325 C  CB  . PHE C 1 20  ? -7.81553  -16.69238 78.26813 1.000 44.61691  ? 16  PHE C CB  1 
ATOM   2326 C  CG  . PHE C 1 20  ? -8.93057  -17.60268 78.70383 1.000 40.20653  ? 16  PHE C CG  1 
ATOM   2327 C  CD1 . PHE C 1 20  ? -8.72044  -18.96496 78.83841 1.000 35.99940  ? 16  PHE C CD1 1 
ATOM   2328 C  CD2 . PHE C 1 20  ? -10.18814 -17.09390 78.98536 1.000 34.26353  ? 16  PHE C CD2 1 
ATOM   2329 C  CE1 . PHE C 1 20  ? -9.74420  -19.80088 79.24670 1.000 33.75207  ? 16  PHE C CE1 1 
ATOM   2330 C  CE2 . PHE C 1 20  ? -11.21529 -17.92602 79.38900 1.000 37.02109  ? 16  PHE C CE2 1 
ATOM   2331 C  CZ  . PHE C 1 20  ? -10.99278 -19.28088 79.51908 1.000 36.48046  ? 16  PHE C CZ  1 
ATOM   2332 N  N   . SER C 1 21  ? -9.07509  -14.71318 76.04561 1.000 40.75339  ? 17  SER C N   1 
ATOM   2333 C  CA  . SER C 1 21  ? -10.28101 -14.11985 75.47824 1.000 49.85506  ? 17  SER C CA  1 
ATOM   2334 C  C   . SER C 1 21  ? -10.36446 -14.33870 73.97412 1.000 45.68326  ? 17  SER C C   1 
ATOM   2335 O  O   . SER C 1 21  ? -11.46496 -14.33421 73.41105 1.000 44.08171  ? 17  SER C O   1 
ATOM   2336 C  CB  . SER C 1 21  ? -10.33270 -12.62717 75.80052 1.000 49.98664  ? 17  SER C CB  1 
ATOM   2337 O  OG  . SER C 1 21  ? -9.11002  -12.18791 76.36506 1.000 52.66657  ? 17  SER C OG  1 
ATOM   2338 N  N   . LEU C 1 22  ? -9.22193  -14.52272 73.30783 1.000 42.56371  ? 18  LEU C N   1 
ATOM   2339 C  CA  . LEU C 1 22  ? -9.24596  -14.83336 71.88268 1.000 46.00888  ? 18  LEU C CA  1 
ATOM   2340 C  C   . LEU C 1 22  ? -9.91814  -16.17599 71.62955 1.000 41.70938  ? 18  LEU C C   1 
ATOM   2341 O  O   . LEU C 1 22  ? -10.66108 -16.33396 70.65388 1.000 40.70268  ? 18  LEU C O   1 
ATOM   2342 C  CB  . LEU C 1 22  ? -7.82560  -14.82708 71.31788 1.000 42.33974  ? 18  LEU C CB  1 
ATOM   2343 N  N   . PHE C 1 23  ? -9.67408  -17.15414 72.50303 1.000 40.41213  ? 19  PHE C N   1 
ATOM   2344 C  CA  . PHE C 1 23  ? -10.32449 -18.45302 72.37320 1.000 35.41109  ? 19  PHE C CA  1 
ATOM   2345 C  C   . PHE C 1 23  ? -11.74488 -18.41424 72.92000 1.000 41.48747  ? 19  PHE C C   1 
ATOM   2346 O  O   . PHE C 1 23  ? -12.68345 -18.88206 72.26629 1.000 38.09430  ? 19  PHE C O   1 
ATOM   2347 C  CB  . PHE C 1 23  ? -9.50419  -19.52209 73.09163 1.000 33.23343  ? 19  PHE C CB  1 
ATOM   2348 C  CG  . PHE C 1 23  ? -8.22821  -19.86955 72.39325 1.000 36.86507  ? 19  PHE C CG  1 
ATOM   2349 C  CD1 . PHE C 1 23  ? -8.19815  -20.86623 71.43408 1.000 42.97483  ? 19  PHE C CD1 1 
ATOM   2350 C  CD2 . PHE C 1 23  ? -7.06047  -19.18791 72.68396 1.000 39.52941  ? 19  PHE C CD2 1 
ATOM   2351 C  CE1 . PHE C 1 23  ? -7.02459  -21.18388 70.78684 1.000 45.10614  ? 19  PHE C CE1 1 
ATOM   2352 C  CE2 . PHE C 1 23  ? -5.88642  -19.50012 72.03877 1.000 47.95936  ? 19  PHE C CE2 1 
ATOM   2353 C  CZ  . PHE C 1 23  ? -5.87005  -20.49854 71.08731 1.000 47.86907  ? 19  PHE C CZ  1 
ATOM   2354 N  N   . ASP C 1 24  ? -11.91856 -17.86542 74.12110 1.000 37.60316  ? 20  ASP C N   1 
ATOM   2355 C  CA  . ASP C 1 24  ? -13.24493 -17.71560 74.70390 1.000 35.09140  ? 20  ASP C CA  1 
ATOM   2356 C  C   . ASP C 1 24  ? -14.03393 -16.65476 73.94954 1.000 42.27641  ? 20  ASP C C   1 
ATOM   2357 O  O   . ASP C 1 24  ? -14.00252 -15.47477 74.31289 1.000 48.39988  ? 20  ASP C O   1 
ATOM   2358 C  CB  . ASP C 1 24  ? -13.14537 -17.35293 76.18561 1.000 35.81930  ? 20  ASP C CB  1 
ATOM   2359 C  CG  . ASP C 1 24  ? -14.44634 -17.57364 76.92276 1.000 39.92315  ? 20  ASP C CG  1 
ATOM   2360 O  OD1 . ASP C 1 24  ? -15.32364 -18.27436 76.37804 1.000 35.02740  ? 20  ASP C OD1 1 
ATOM   2361 O  OD2 . ASP C 1 24  ? -14.59549 -17.04211 78.04142 1.000 42.54944  ? 20  ASP C OD2 1 
ATOM   2362 N  N   . LYS C 1 25  ? -14.74815 -17.06670 72.90038 1.000 35.05346  ? 21  LYS C N   1 
ATOM   2363 C  CA  . LYS C 1 25  ? -15.43076 -16.10064 72.04608 1.000 37.42997  ? 21  LYS C CA  1 
ATOM   2364 C  C   . LYS C 1 25  ? -16.65829 -15.51724 72.73648 1.000 43.17513  ? 21  LYS C C   1 
ATOM   2365 O  O   . LYS C 1 25  ? -16.84942 -14.29599 72.75329 1.000 47.81917  ? 21  LYS C O   1 
ATOM   2366 C  CB  . LYS C 1 25  ? -15.81066 -16.75485 70.71757 1.000 33.61119  ? 21  LYS C CB  1 
ATOM   2367 C  CG  . LYS C 1 25  ? -14.61804 -17.28383 69.93546 1.000 35.62324  ? 21  LYS C CG  1 
ATOM   2368 C  CD  . LYS C 1 25  ? -13.79680 -16.14323 69.35125 1.000 38.20668  ? 21  LYS C CD  1 
ATOM   2369 C  CE  . LYS C 1 25  ? -12.84952 -16.63539 68.26797 1.000 28.51054  ? 21  LYS C CE  1 
ATOM   2370 N  NZ  . LYS C 1 25  ? -11.73467 -15.67589 68.02571 1.000 27.42621  ? 21  LYS C NZ  1 
ATOM   2371 N  N   . ASP C 1 26  ? -17.50487 -16.37244 73.31350 1.000 42.01713  ? 22  ASP C N   1 
ATOM   2372 C  CA  . ASP C 1 26  ? -18.70872 -15.88195 73.97442 1.000 41.37074  ? 22  ASP C CA  1 
ATOM   2373 C  C   . ASP C 1 26  ? -18.41943 -15.19472 75.30335 1.000 40.39306  ? 22  ASP C C   1 
ATOM   2374 O  O   . ASP C 1 26  ? -19.30761 -14.52153 75.83742 1.000 53.69002  ? 22  ASP C O   1 
ATOM   2375 C  CB  . ASP C 1 26  ? -19.70301 -17.02800 74.18264 1.000 37.73281  ? 22  ASP C CB  1 
ATOM   2376 C  CG  . ASP C 1 26  ? -19.14052 -18.15194 75.03499 1.000 38.75843  ? 22  ASP C CG  1 
ATOM   2377 O  OD1 . ASP C 1 26  ? -18.01591 -18.01394 75.55737 1.000 39.72001  ? 22  ASP C OD1 1 
ATOM   2378 O  OD2 . ASP C 1 26  ? -19.83167 -19.18073 75.18663 1.000 40.14244  ? 22  ASP C OD2 1 
ATOM   2379 N  N   . GLY C 1 27  ? -17.21430 -15.34886 75.84657 1.000 45.73834  ? 23  GLY C N   1 
ATOM   2380 C  CA  . GLY C 1 27  ? -16.86893 -14.70142 77.09654 1.000 46.14391  ? 23  GLY C CA  1 
ATOM   2381 C  C   . GLY C 1 27  ? -17.45392 -15.34656 78.33067 1.000 46.14366  ? 23  GLY C C   1 
ATOM   2382 O  O   . GLY C 1 27  ? -17.64814 -14.66607 79.34282 1.000 49.09772  ? 23  GLY C O   1 
ATOM   2383 N  N   . ASP C 1 28  ? -17.73985 -16.64498 78.28129 1.000 46.87504  ? 24  ASP C N   1 
ATOM   2384 C  CA  . ASP C 1 28  ? -18.32309 -17.35189 79.41294 1.000 43.89370  ? 24  ASP C CA  1 
ATOM   2385 C  C   . ASP C 1 28  ? -17.27835 -17.92950 80.36040 1.000 42.31334  ? 24  ASP C C   1 
ATOM   2386 O  O   . ASP C 1 28  ? -17.64850 -18.57409 81.34701 1.000 42.61751  ? 24  ASP C O   1 
ATOM   2387 C  CB  . ASP C 1 28  ? -19.25122 -18.46756 78.91704 1.000 39.71754  ? 24  ASP C CB  1 
ATOM   2388 C  CG  . ASP C 1 28  ? -18.49378 -19.68375 78.41587 1.000 43.37281  ? 24  ASP C CG  1 
ATOM   2389 O  OD1 . ASP C 1 28  ? -17.34379 -19.53110 77.95077 1.000 36.38812  ? 24  ASP C OD1 1 
ATOM   2390 O  OD2 . ASP C 1 28  ? -19.05099 -20.79856 78.49096 1.000 42.36580  ? 24  ASP C OD2 1 
ATOM   2391 N  N   . GLY C 1 29  ? -15.99153 -17.72274 80.08576 1.000 42.11289  ? 25  GLY C N   1 
ATOM   2392 C  CA  . GLY C 1 29  ? -14.93503 -18.19875 80.95281 1.000 43.24791  ? 25  GLY C CA  1 
ATOM   2393 C  C   . GLY C 1 29  ? -14.39626 -19.57583 80.63212 1.000 35.96461  ? 25  GLY C C   1 
ATOM   2394 O  O   . GLY C 1 29  ? -13.48614 -20.04098 81.32977 1.000 39.63799  ? 25  GLY C O   1 
ATOM   2395 N  N   . THR C 1 30  ? -14.92559 -20.24764 79.60993 1.000 34.38869  ? 26  THR C N   1 
ATOM   2396 C  CA  . THR C 1 30  ? -14.48113 -21.58578 79.24456 1.000 36.70774  ? 26  THR C CA  1 
ATOM   2397 C  C   . THR C 1 30  ? -14.32875 -21.68130 77.73449 1.000 36.67851  ? 26  THR C C   1 
ATOM   2398 O  O   . THR C 1 30  ? -15.11839 -21.10062 76.98558 1.000 35.49870  ? 26  THR C O   1 
ATOM   2399 C  CB  . THR C 1 30  ? -15.46257 -22.66647 79.72747 1.000 38.64163  ? 26  THR C CB  1 
ATOM   2400 O  OG1 . THR C 1 30  ? -16.75559 -22.43295 79.15549 1.000 37.49158  ? 26  THR C OG1 1 
ATOM   2401 C  CG2 . THR C 1 30  ? -15.57115 -22.66591 81.24700 1.000 40.48133  ? 26  THR C CG2 1 
ATOM   2402 N  N   . ILE C 1 31  ? -13.31684 -22.42263 77.29397 1.000 34.34617  ? 27  ILE C N   1 
ATOM   2403 C  CA  . ILE C 1 31  ? -13.07066 -22.66038 75.87641 1.000 28.81114  ? 27  ILE C CA  1 
ATOM   2404 C  C   . ILE C 1 31  ? -13.63370 -24.02802 75.51918 1.000 33.94208  ? 27  ILE C C   1 
ATOM   2405 O  O   . ILE C 1 31  ? -13.21065 -25.04764 76.07687 1.000 30.06590  ? 27  ILE C O   1 
ATOM   2406 C  CB  . ILE C 1 31  ? -11.57405 -22.57918 75.53953 1.000 30.87455  ? 27  ILE C CB  1 
ATOM   2407 C  CG1 . ILE C 1 31  ? -10.99061 -21.24189 75.99360 1.000 31.95530  ? 27  ILE C CG1 1 
ATOM   2408 C  CG2 . ILE C 1 31  ? -11.35381 -22.78101 74.04716 1.000 31.93490  ? 27  ILE C CG2 1 
ATOM   2409 C  CD1 . ILE C 1 31  ? -9.49434  -21.27681 76.17381 1.000 24.55830  ? 27  ILE C CD1 1 
ATOM   2410 N  N   . THR C 1 32  ? -14.58472 -24.05308 74.59320 1.000 31.48231  ? 28  THR C N   1 
ATOM   2411 C  CA  . THR C 1 32  ? -15.17729 -25.29235 74.11730 1.000 29.73167  ? 28  THR C CA  1 
ATOM   2412 C  C   . THR C 1 32  ? -14.49126 -25.74963 72.83455 1.000 22.63392  ? 28  THR C C   1 
ATOM   2413 O  O   . THR C 1 32  ? -13.69080 -25.03008 72.23235 1.000 23.90250  ? 28  THR C O   1 
ATOM   2414 C  CB  . THR C 1 32  ? -16.68122 -25.11921 73.87932 1.000 33.46551  ? 28  THR C CB  1 
ATOM   2415 O  OG1 . THR C 1 32  ? -16.89194 -24.19232 72.80747 1.000 25.74082  ? 28  THR C OG1 1 
ATOM   2416 C  CG2 . THR C 1 32  ? -17.36908 -24.60356 75.13459 1.000 22.99007  ? 28  THR C CG2 1 
ATOM   2417 N  N   . THR C 1 33  ? -14.82081 -26.97572 72.41985 1.000 25.26405  ? 29  THR C N   1 
ATOM   2418 C  CA  . THR C 1 33  ? -14.30419 -27.49342 71.15673 1.000 22.57891  ? 29  THR C CA  1 
ATOM   2419 C  C   . THR C 1 33  ? -14.73414 -26.61495 69.98995 1.000 21.00854  ? 29  THR C C   1 
ATOM   2420 O  O   . THR C 1 33  ? -13.98453 -26.44114 69.02185 1.000 21.43900  ? 29  THR C O   1 
ATOM   2421 C  CB  . THR C 1 33  ? -14.78218 -28.92932 70.93992 1.000 32.10940  ? 29  THR C CB  1 
ATOM   2422 O  OG1 . THR C 1 33  ? -16.19208 -29.00493 71.18721 1.000 29.49405  ? 29  THR C OG1 1 
ATOM   2423 C  CG2 . THR C 1 33  ? -14.05793 -29.88246 71.87905 1.000 22.72377  ? 29  THR C CG2 1 
ATOM   2424 N  N   . LYS C 1 34  ? -15.94138 -26.05043 70.06851 1.000 32.30209  ? 30  LYS C N   1 
ATOM   2425 C  CA  . LYS C 1 34  ? -16.43507 -25.19041 68.99937 1.000 24.17826  ? 30  LYS C CA  1 
ATOM   2426 C  C   . LYS C 1 34  ? -15.61617 -23.91050 68.89827 1.000 23.25512  ? 30  LYS C C   1 
ATOM   2427 O  O   . LYS C 1 34  ? -15.28500 -23.46485 67.79400 1.000 24.88929  ? 30  LYS C O   1 
ATOM   2428 C  CB  . LYS C 1 34  ? -17.91047 -24.86853 69.23228 1.000 26.08819  ? 30  LYS C CB  1 
ATOM   2429 C  CG  . LYS C 1 34  ? -18.85657 -25.99291 68.85157 1.000 27.69590  ? 30  LYS C CG  1 
ATOM   2430 C  CD  . LYS C 1 34  ? -20.29876 -25.61811 69.13796 1.000 29.42778  ? 30  LYS C CD  1 
ATOM   2431 C  CE  . LYS C 1 34  ? -20.54939 -25.50980 70.63321 1.000 30.17533  ? 30  LYS C CE  1 
ATOM   2432 N  NZ  . LYS C 1 34  ? -20.60462 -26.84819 71.28786 1.000 32.09937  ? 30  LYS C NZ  1 
ATOM   2433 N  N   . GLU C 1 35  ? -15.27796 -23.30697 70.03948 1.000 23.01588  ? 31  GLU C N   1 
ATOM   2434 C  CA  . GLU C 1 35  ? -14.47115 -22.09167 70.01771 1.000 23.56498  ? 31  GLU C CA  1 
ATOM   2435 C  C   . GLU C 1 35  ? -13.04099 -22.38640 69.58385 1.000 24.36777  ? 31  GLU C C   1 
ATOM   2436 O  O   . GLU C 1 35  ? -12.41046 -21.56530 68.90738 1.000 34.47714  ? 31  GLU C O   1 
ATOM   2437 C  CB  . GLU C 1 35  ? -14.49403 -21.42296 71.39116 1.000 22.69764  ? 31  GLU C CB  1 
ATOM   2438 C  CG  . GLU C 1 35  ? -15.75419 -20.61755 71.65647 1.000 32.13134  ? 31  GLU C CG  1 
ATOM   2439 C  CD  . GLU C 1 35  ? -16.01589 -20.41328 73.13329 1.000 31.00413  ? 31  GLU C CD  1 
ATOM   2440 O  OE1 . GLU C 1 35  ? -15.47144 -21.18765 73.94878 1.000 30.77410  ? 31  GLU C OE1 1 
ATOM   2441 O  OE2 . GLU C 1 35  ? -16.76599 -19.47642 73.47756 1.000 29.21456  ? 31  GLU C OE2 1 
ATOM   2442 N  N   . LEU C 1 36  ? -12.51159 -23.55251 69.96243 1.000 22.69507  ? 32  LEU C N   1 
ATOM   2443 C  CA  . LEU C 1 36  ? -11.18063 -23.93620 69.50400 1.000 29.44953  ? 32  LEU C CA  1 
ATOM   2444 C  C   . LEU C 1 36  ? -11.16351 -24.15795 67.99691 1.000 27.36103  ? 32  LEU C C   1 
ATOM   2445 O  O   . LEU C 1 36  ? -10.22868 -23.72793 67.31183 1.000 28.38991  ? 32  LEU C O   1 
ATOM   2446 C  CB  . LEU C 1 36  ? -10.70958 -25.19068 70.23993 1.000 18.35077  ? 32  LEU C CB  1 
ATOM   2447 C  CG  . LEU C 1 36  ? -9.25598  -25.61265 70.00921 1.000 37.61903  ? 32  LEU C CG  1 
ATOM   2448 C  CD1 . LEU C 1 36  ? -8.31068  -24.43063 70.15728 1.000 34.80638  ? 32  LEU C CD1 1 
ATOM   2449 C  CD2 . LEU C 1 36  ? -8.86345  -26.74061 70.95251 1.000 36.08472  ? 32  LEU C CD2 1 
ATOM   2450 N  N   . GLY C 1 37  ? -12.19207 -24.82046 67.46237 1.000 34.02281  ? 33  GLY C N   1 
ATOM   2451 C  CA  . GLY C 1 37  ? -12.27315 -24.99906 66.02179 1.000 26.31756  ? 33  GLY C CA  1 
ATOM   2452 C  C   . GLY C 1 37  ? -12.41464 -23.68440 65.28082 1.000 22.37820  ? 33  GLY C C   1 
ATOM   2453 O  O   . GLY C 1 37  ? -11.87129 -23.51562 64.18635 1.000 22.69792  ? 33  GLY C O   1 
ATOM   2454 N  N   . THR C 1 38  ? -13.14746 -22.73441 65.86740 1.000 26.26872  ? 34  THR C N   1 
ATOM   2455 C  CA  . THR C 1 38  ? -13.26769 -21.41074 65.26462 1.000 25.15604  ? 34  THR C CA  1 
ATOM   2456 C  C   . THR C 1 38  ? -11.91092 -20.72224 65.17823 1.000 22.11556  ? 34  THR C C   1 
ATOM   2457 O  O   . THR C 1 38  ? -11.59489 -20.07580 64.17188 1.000 27.06953  ? 34  THR C O   1 
ATOM   2458 C  CB  . THR C 1 38  ? -14.25329 -20.55801 66.06707 1.000 24.99252  ? 34  THR C CB  1 
ATOM   2459 O  OG1 . THR C 1 38  ? -15.58688 -21.04285 65.86380 1.000 28.53148  ? 34  THR C OG1 1 
ATOM   2460 C  CG2 . THR C 1 38  ? -14.17763 -19.09580 65.64305 1.000 26.20557  ? 34  THR C CG2 1 
ATOM   2461 N  N   . VAL C 1 39  ? -11.08849 -20.86437 66.21888 1.000 27.49001  ? 35  VAL C N   1 
ATOM   2462 C  CA  . VAL C 1 39  ? -9.77899  -20.21879 66.22914 1.000 29.90257  ? 35  VAL C CA  1 
ATOM   2463 C  C   . VAL C 1 39  ? -8.83785  -20.90381 65.24534 1.000 23.35332  ? 35  VAL C C   1 
ATOM   2464 O  O   . VAL C 1 39  ? -8.13827  -20.24309 64.46842 1.000 27.85490  ? 35  VAL C O   1 
ATOM   2465 C  CB  . VAL C 1 39  ? -9.19585  -20.21036 67.65397 1.000 26.98042  ? 35  VAL C CB  1 
ATOM   2466 C  CG1 . VAL C 1 39  ? -7.74928  -19.74685 67.63024 1.000 34.07797  ? 35  VAL C CG1 1 
ATOM   2467 C  CG2 . VAL C 1 39  ? -10.03166 -19.32418 68.56515 1.000 28.46190  ? 35  VAL C CG2 1 
HETATM 2468 N  N   . MSE C 1 40  ? -8.80495  -22.23379 65.26489 1.000 33.35468  ? 36  MSE C N   1 
HETATM 2469 C  CA  . MSE C 1 40  ? -7.92143  -22.99993 64.38918 1.000 26.43528  ? 36  MSE C CA  1 
HETATM 2470 C  C   . MSE C 1 40  ? -8.21752  -22.73366 62.91743 1.000 31.98469  ? 36  MSE C C   1 
HETATM 2471 O  O   . MSE C 1 40  ? -7.30169  -22.61973 62.10101 1.000 30.02079  ? 36  MSE C O   1 
HETATM 2472 C  CB  . MSE C 1 40  ? -8.04236  -24.49762 64.68432 1.000 28.08105  ? 36  MSE C CB  1 
HETATM 2473 C  CG  . MSE C 1 40  ? -7.57578  -24.89571 66.07568 1.000 35.82132  ? 36  MSE C CG  1 
HETATM 2474 SE SE  . MSE C 1 40  ? -5.66233  -24.63207 66.34663 1.000 50.01164  ? 36  MSE C SE  1 
HETATM 2475 C  CE  . MSE C 1 40  ? -4.98859  -25.91089 65.04065 1.000 47.09407  ? 36  MSE C CE  1 
ATOM   2476 N  N   . ARG C 1 41  ? -9.50642  -22.63508 62.58340 1.000 27.21897  ? 37  ARG C N   1 
ATOM   2477 C  CA  . ARG C 1 41  ? -9.88495  -22.32886 61.20884 1.000 27.64797  ? 37  ARG C CA  1 
ATOM   2478 C  C   . ARG C 1 41  ? -9.52051  -20.89924 60.83542 1.000 21.72818  ? 37  ARG C C   1 
ATOM   2479 O  O   . ARG C 1 41  ? -9.16553  -20.63327 59.68196 1.000 30.23510  ? 37  ARG C O   1 
ATOM   2480 C  CB  . ARG C 1 41  ? -11.37953 -22.57681 61.00708 1.000 23.00985  ? 37  ARG C CB  1 
ATOM   2481 C  CG  . ARG C 1 41  ? -11.74677 -24.04950 60.96758 1.000 24.95007  ? 37  ARG C CG  1 
ATOM   2482 C  CD  . ARG C 1 41  ? -13.20249 -24.25089 60.59228 1.000 16.34882  ? 37  ARG C CD  1 
ATOM   2483 N  NE  . ARG C 1 41  ? -14.10539 -23.72196 61.60697 1.000 18.96233  ? 37  ARG C NE  1 
ATOM   2484 C  CZ  . ARG C 1 41  ? -14.50266 -24.39536 62.67764 1.000 25.48478  ? 37  ARG C CZ  1 
ATOM   2485 N  NH1 . ARG C 1 41  ? -14.07321 -25.62332 62.92033 1.000 26.47556  ? 37  ARG C NH1 1 
ATOM   2486 N  NH2 . ARG C 1 41  ? -15.35148 -23.82258 63.52656 1.000 24.02346  ? 37  ARG C NH2 1 
ATOM   2487 N  N   . SER C 1 42  ? -9.59295  -19.97104 61.79203 1.000 27.10425  ? 38  SER C N   1 
ATOM   2488 C  CA  . SER C 1 42  ? -9.11947  -18.61411 61.55051 1.000 23.97854  ? 38  SER C CA  1 
ATOM   2489 C  C   . SER C 1 42  ? -7.61169  -18.56470 61.34971 1.000 31.69748  ? 38  SER C C   1 
ATOM   2490 O  O   . SER C 1 42  ? -7.09375  -17.54927 60.87337 1.000 26.05683  ? 38  SER C O   1 
ATOM   2491 C  CB  . SER C 1 42  ? -9.52302  -17.70278 62.70999 1.000 26.69278  ? 38  SER C CB  1 
ATOM   2492 O  OG  . SER C 1 42  ? -8.62206  -17.83725 63.79405 1.000 36.98540  ? 38  SER C OG  1 
ATOM   2493 N  N   . LEU C 1 43  ? -6.90152  -19.63643 61.70453 1.000 26.94134  ? 39  LEU C N   1 
ATOM   2494 C  CA  . LEU C 1 43  ? -5.46146  -19.74009 61.51591 1.000 35.61675  ? 39  LEU C CA  1 
ATOM   2495 C  C   . LEU C 1 43  ? -5.09920  -20.68598 60.37602 1.000 36.91155  ? 39  LEU C C   1 
ATOM   2496 O  O   . LEU C 1 43  ? -4.00122  -21.24883 60.36673 1.000 38.20269  ? 39  LEU C O   1 
ATOM   2497 C  CB  . LEU C 1 43  ? -4.79154  -20.19072 62.81448 1.000 34.40174  ? 39  LEU C CB  1 
ATOM   2498 C  CG  . LEU C 1 43  ? -4.94718  -19.25913 64.01912 1.000 32.72347  ? 39  LEU C CG  1 
ATOM   2499 C  CD1 . LEU C 1 43  ? -3.99219  -19.65599 65.13308 1.000 41.37335  ? 39  LEU C CD1 1 
ATOM   2500 C  CD2 . LEU C 1 43  ? -4.72731  -17.80880 63.61316 1.000 33.18978  ? 39  LEU C CD2 1 
ATOM   2501 N  N   . GLY C 1 44  ? -6.00593  -20.88248 59.42129 1.000 29.96560  ? 40  GLY C N   1 
ATOM   2502 C  CA  . GLY C 1 44  ? -5.71111  -21.70755 58.26737 1.000 26.55191  ? 40  GLY C CA  1 
ATOM   2503 C  C   . GLY C 1 44  ? -5.63508  -23.19447 58.52521 1.000 28.67097  ? 40  GLY C C   1 
ATOM   2504 O  O   . GLY C 1 44  ? -5.25123  -23.94198 57.62125 1.000 29.85104  ? 40  GLY C O   1 
ATOM   2505 N  N   . GLN C 1 45  ? -5.98121  -23.65126 59.72364 1.000 25.15312  ? 41  GLN C N   1 
ATOM   2506 C  CA  . GLN C 1 45  ? -6.00346  -25.07040 60.04334 1.000 38.65573  ? 41  GLN C CA  1 
ATOM   2507 C  C   . GLN C 1 45  ? -7.42521  -25.61008 59.93530 1.000 32.03852  ? 41  GLN C C   1 
ATOM   2508 O  O   . GLN C 1 45  ? -8.40100  -24.85713 59.91555 1.000 28.69250  ? 41  GLN C O   1 
ATOM   2509 C  CB  . GLN C 1 45  ? -5.44766  -25.32031 61.44761 1.000 40.47667  ? 41  GLN C CB  1 
ATOM   2510 C  CG  . GLN C 1 45  ? -4.29246  -24.40692 61.82669 1.000 32.97486  ? 41  GLN C CG  1 
ATOM   2511 C  CD  . GLN C 1 45  ? -3.05828  -24.65088 60.98300 1.000 36.21777  ? 41  GLN C CD  1 
ATOM   2512 O  OE1 . GLN C 1 45  ? -2.54673  -25.76934 60.91861 1.000 34.05145  ? 41  GLN C OE1 1 
ATOM   2513 N  NE2 . GLN C 1 45  ? -2.57284  -23.60195 60.32827 1.000 29.69559  ? 41  GLN C NE2 1 
ATOM   2514 N  N   . ASN C 1 46  ? -7.53424  -26.93441 59.85962 1.000 33.36119  ? 42  ASN C N   1 
ATOM   2515 C  CA  . ASN C 1 46  ? -8.82760  -27.60874 59.73168 1.000 25.55551  ? 42  ASN C CA  1 
ATOM   2516 C  C   . ASN C 1 46  ? -8.82661  -28.88383 60.56362 1.000 30.45386  ? 42  ASN C C   1 
ATOM   2517 O  O   . ASN C 1 46  ? -8.73711  -29.99646 60.03219 1.000 25.97287  ? 42  ASN C O   1 
ATOM   2518 C  CB  . ASN C 1 46  ? -9.13987  -27.90746 58.26415 1.000 33.55391  ? 42  ASN C CB  1 
ATOM   2519 C  CG  . ASN C 1 46  ? -10.61610 -27.80237 57.95299 1.000 45.00636  ? 42  ASN C CG  1 
ATOM   2520 O  OD1 . ASN C 1 46  ? -11.40295 -28.67466 58.31907 1.000 51.44454  ? 42  ASN C OD1 1 
ATOM   2521 N  ND2 . ASN C 1 46  ? -11.00312 -26.72497 57.27991 1.000 51.72023  ? 42  ASN C ND2 1 
ATOM   2522 N  N   . PRO C 1 47  ? -8.93602  -28.75693 61.88268 1.000 29.65166  ? 43  PRO C N   1 
ATOM   2523 C  CA  . PRO C 1 47  ? -9.01153  -29.94859 62.73143 1.000 34.69580  ? 43  PRO C CA  1 
ATOM   2524 C  C   . PRO C 1 47  ? -10.39329 -30.58066 62.69922 1.000 32.19257  ? 43  PRO C C   1 
ATOM   2525 O  O   . PRO C 1 47  ? -11.41152 -29.90852 62.52453 1.000 30.65175  ? 43  PRO C O   1 
ATOM   2526 C  CB  . PRO C 1 47  ? -8.69015  -29.40428 64.12806 1.000 28.20301  ? 43  PRO C CB  1 
ATOM   2527 C  CG  . PRO C 1 47  ? -9.14618  -27.98752 64.07763 1.000 26.73071  ? 43  PRO C CG  1 
ATOM   2528 C  CD  . PRO C 1 47  ? -8.91102  -27.51268 62.67237 1.000 29.58902  ? 43  PRO C CD  1 
ATOM   2529 N  N   . THR C 1 48  ? -10.41442 -31.89901 62.87216 1.000 34.06177  ? 44  THR C N   1 
ATOM   2530 C  CA  . THR C 1 48  ? -11.67067 -32.62580 62.95278 1.000 31.97162  ? 44  THR C CA  1 
ATOM   2531 C  C   . THR C 1 48  ? -12.30645 -32.42834 64.32728 1.000 31.95204  ? 44  THR C C   1 
ATOM   2532 O  O   . THR C 1 48  ? -11.72694 -31.81748 65.22869 1.000 25.69726  ? 44  THR C O   1 
ATOM   2533 C  CB  . THR C 1 48  ? -11.45355 -34.11389 62.67973 1.000 36.50770  ? 44  THR C CB  1 
ATOM   2534 O  OG1 . THR C 1 48  ? -10.91563 -34.74096 63.85031 1.000 27.61556  ? 44  THR C OG1 1 
ATOM   2535 C  CG2 . THR C 1 48  ? -10.48957 -34.30905 61.51869 1.000 28.62353  ? 44  THR C CG2 1 
ATOM   2536 N  N   . GLU C 1 49  ? -13.52087 -32.96060 64.48678 1.000 25.65677  ? 45  GLU C N   1 
ATOM   2537 C  CA  . GLU C 1 49  ? -14.20146 -32.83651 65.77182 1.000 30.95499  ? 45  GLU C CA  1 
ATOM   2538 C  C   . GLU C 1 49  ? -13.50971 -33.67222 66.84184 1.000 29.39880  ? 45  GLU C C   1 
ATOM   2539 O  O   . GLU C 1 49  ? -13.38693 -33.23693 67.99161 1.000 37.35133  ? 45  GLU C O   1 
ATOM   2540 C  CB  . GLU C 1 49  ? -15.67827 -33.22993 65.64697 1.000 28.90757  ? 45  GLU C CB  1 
ATOM   2541 C  CG  . GLU C 1 49  ? -15.96185 -34.69421 65.30544 1.000 35.20408  ? 45  GLU C CG  1 
ATOM   2542 C  CD  . GLU C 1 49  ? -15.50734 -35.08863 63.91605 1.000 31.45758  ? 45  GLU C CD  1 
ATOM   2543 O  OE1 . GLU C 1 49  ? -16.10869 -34.60930 62.93241 1.000 45.54380  ? 45  GLU C OE1 1 
ATOM   2544 O  OE2 . GLU C 1 49  ? -14.54812 -35.88135 63.80681 1.000 31.32136  ? 45  GLU C OE2 1 
ATOM   2545 N  N   . ALA C 1 50  ? -13.03826 -34.86800 66.48263 1.000 30.51528  ? 46  ALA C N   1 
ATOM   2546 C  CA  . ALA C 1 50  ? -12.36339 -35.71136 67.46148 1.000 28.87623  ? 46  ALA C CA  1 
ATOM   2547 C  C   . ALA C 1 50  ? -10.96547 -35.19527 67.77294 1.000 31.76282  ? 46  ALA C C   1 
ATOM   2548 O  O   . ALA C 1 50  ? -10.48224 -35.36329 68.89810 1.000 28.85567  ? 46  ALA C O   1 
ATOM   2549 C  CB  . ALA C 1 50  ? -12.30655 -37.15536 66.96327 1.000 28.99534  ? 46  ALA C CB  1 
ATOM   2550 N  N   . GLU C 1 51  ? -10.30556 -34.56538 66.79740 1.000 24.81551  ? 47  GLU C N   1 
ATOM   2551 C  CA  . GLU C 1 51  ? -9.00436  -33.95876 67.05870 1.000 31.49285  ? 47  GLU C CA  1 
ATOM   2552 C  C   . GLU C 1 51  ? -9.13305  -32.77649 68.00989 1.000 36.89444  ? 47  GLU C C   1 
ATOM   2553 O  O   . GLU C 1 51  ? -8.31735  -32.61665 68.92530 1.000 29.88991  ? 47  GLU C O   1 
ATOM   2554 C  CB  . GLU C 1 51  ? -8.35471  -33.52140 65.74666 1.000 26.62615  ? 47  GLU C CB  1 
ATOM   2555 C  CG  . GLU C 1 51  ? -7.52317  -34.60057 65.07507 1.000 22.83351  ? 47  GLU C CG  1 
ATOM   2556 C  CD  . GLU C 1 51  ? -7.34728  -34.35604 63.59017 1.000 31.74244  ? 47  GLU C CD  1 
ATOM   2557 O  OE1 . GLU C 1 51  ? -7.58032  -33.21266 63.14296 1.000 29.08947  ? 47  GLU C OE1 1 
ATOM   2558 O  OE2 . GLU C 1 51  ? -6.97951  -35.30747 62.86973 1.000 35.73875  ? 47  GLU C OE2 1 
ATOM   2559 N  N   . LEU C 1 52  ? -10.15187 -31.93726 67.80522 1.000 37.02074  ? 48  LEU C N   1 
ATOM   2560 C  CA  . LEU C 1 52  ? -10.41087 -30.83699 68.72803 1.000 33.98527  ? 48  LEU C CA  1 
ATOM   2561 C  C   . LEU C 1 52  ? -10.70975 -31.35393 70.12803 1.000 35.86352  ? 48  LEU C C   1 
ATOM   2562 O  O   . LEU C 1 52  ? -10.26872 -30.76663 71.12248 1.000 34.79269  ? 48  LEU C O   1 
ATOM   2563 C  CB  . LEU C 1 52  ? -11.57100 -29.98927 68.21023 1.000 28.73520  ? 48  LEU C CB  1 
ATOM   2564 C  CG  . LEU C 1 52  ? -11.25436 -29.10041 67.01068 1.000 27.03056  ? 48  LEU C CG  1 
ATOM   2565 C  CD1 . LEU C 1 52  ? -12.53547 -28.54337 66.42729 1.000 32.56523  ? 48  LEU C CD1 1 
ATOM   2566 C  CD2 . LEU C 1 52  ? -10.33533 -27.97309 67.43819 1.000 32.33700  ? 48  LEU C CD2 1 
ATOM   2567 N  N   . GLN C 1 53  ? -11.46142 -32.45331 70.22412 1.000 24.73198  ? 49  GLN C N   1 
ATOM   2568 C  CA  . GLN C 1 53  ? -11.72345 -33.06319 71.52348 1.000 35.90456  ? 49  GLN C CA  1 
ATOM   2569 C  C   . GLN C 1 53  ? -10.43694 -33.57535 72.16029 1.000 36.84301  ? 49  GLN C C   1 
ATOM   2570 O  O   . GLN C 1 53  ? -10.25622 -33.47695 73.38010 1.000 38.39933  ? 49  GLN C O   1 
ATOM   2571 C  CB  . GLN C 1 53  ? -12.73956 -34.19490 71.37020 1.000 37.35918  ? 49  GLN C CB  1 
ATOM   2572 C  CG  . GLN C 1 53  ? -14.14630 -33.72374 71.04065 1.000 35.04427  ? 49  GLN C CG  1 
ATOM   2573 C  CD  . GLN C 1 53  ? -15.13175 -34.86867 70.92735 1.000 40.70000  ? 49  GLN C CD  1 
ATOM   2574 O  OE1 . GLN C 1 53  ? -16.28625 -34.75032 71.33508 1.000 34.58591  ? 49  GLN C OE1 1 
ATOM   2575 N  NE2 . GLN C 1 53  ? -14.68097 -35.98470 70.36589 1.000 33.60323  ? 49  GLN C NE2 1 
ATOM   2576 N  N   . ASP C 1 54  ? -9.52981  -34.12523 71.34863 1.000 30.25968  ? 50  ASP C N   1 
ATOM   2577 C  CA  . ASP C 1 54  ? -8.23474  -34.55347 71.86840 1.000 40.73409  ? 50  ASP C CA  1 
ATOM   2578 C  C   . ASP C 1 54  ? -7.43116  -33.36540 72.38083 1.000 39.66786  ? 50  ASP C C   1 
ATOM   2579 O  O   . ASP C 1 54  ? -6.76315  -33.45379 73.41671 1.000 44.08618  ? 50  ASP C O   1 
ATOM   2580 C  CB  . ASP C 1 54  ? -7.45415  -35.29604 70.78331 1.000 32.43788  ? 50  ASP C CB  1 
ATOM   2581 C  CG  . ASP C 1 54  ? -7.93212  -36.72002 70.59177 1.000 43.44170  ? 50  ASP C CG  1 
ATOM   2582 O  OD1 . ASP C 1 54  ? -8.55051  -37.27041 71.52699 1.000 49.60146  ? 50  ASP C OD1 1 
ATOM   2583 O  OD2 . ASP C 1 54  ? -7.68642  -37.29110 69.50854 1.000 49.09076  ? 50  ASP C OD2 1 
HETATM 2584 N  N   . MSE C 1 55  ? -7.49021  -32.24714 71.67085 1.000 36.29686  ? 51  MSE C N   1 
HETATM 2585 C  CA  . MSE C 1 55  ? -6.75575  -31.04207 72.02840 1.000 35.80167  ? 51  MSE C CA  1 
HETATM 2586 C  C   . MSE C 1 55  ? -7.23182  -30.49542 73.36963 1.000 39.65085  ? 51  MSE C C   1 
HETATM 2587 O  O   . MSE C 1 55  ? -6.42777  -30.08595 74.20930 1.000 41.49124  ? 51  MSE C O   1 
HETATM 2588 C  CB  . MSE C 1 55  ? -6.92648  -29.99780 70.93021 1.000 35.14413  ? 51  MSE C CB  1 
HETATM 2589 C  CG  . MSE C 1 55  ? -6.01559  -30.22446 69.73870 1.000 46.73025  ? 51  MSE C CG  1 
HETATM 2590 SE SE  . MSE C 1 55  ? -6.59313  -29.22315 68.16702 1.000 62.96935  ? 51  MSE C SE  1 
HETATM 2591 C  CE  . MSE C 1 55  ? -5.43216  -27.66953 68.30038 1.000 47.59110  ? 51  MSE C CE  1 
ATOM   2592 N  N   . ILE C 1 56  ? -8.55329  -30.49402 73.55681 1.000 39.21827  ? 52  ILE C N   1 
ATOM   2593 C  CA  . ILE C 1 56  ? -9.12942  -30.05827 74.82375 1.000 42.71605  ? 52  ILE C CA  1 
ATOM   2594 C  C   . ILE C 1 56  ? -8.75405  -31.02665 75.93792 1.000 44.31950  ? 52  ILE C C   1 
ATOM   2595 O  O   . ILE C 1 56  ? -8.38009  -30.61026 77.04055 1.000 43.52843  ? 52  ILE C O   1 
ATOM   2596 C  CB  . ILE C 1 56  ? -10.65771 -29.92059 74.69254 1.000 35.38597  ? 52  ILE C CB  1 
ATOM   2597 C  CG1 . ILE C 1 56  ? -11.02992 -28.92722 73.58354 1.000 33.23672  ? 52  ILE C CG1 1 
ATOM   2598 C  CG2 . ILE C 1 56  ? -11.26793 -29.52219 76.03188 1.000 32.19398  ? 52  ILE C CG2 1 
ATOM   2599 C  CD1 . ILE C 1 56  ? -11.32842 -27.51662 74.05018 1.000 36.60515  ? 52  ILE C CD1 1 
ATOM   2600 N  N   . ASN C 1 57  ? -8.83742  -32.33202 75.66066 1.000 45.66822  ? 53  ASN C N   1 
ATOM   2601 C  CA  . ASN C 1 57  ? -8.58152  -33.34705 76.67936 1.000 51.76686  ? 53  ASN C CA  1 
ATOM   2602 C  C   . ASN C 1 57  ? -7.16643  -33.24717 77.23496 1.000 50.71612  ? 53  ASN C C   1 
ATOM   2603 O  O   . ASN C 1 57  ? -6.95531  -33.41064 78.44226 1.000 46.33898  ? 53  ASN C O   1 
ATOM   2604 C  CB  . ASN C 1 57  ? -8.82242  -34.73995 76.09494 1.000 41.62200  ? 53  ASN C CB  1 
ATOM   2605 C  CG  . ASN C 1 57  ? -8.98845  -35.80310 77.16418 1.000 56.74818  ? 53  ASN C CG  1 
ATOM   2606 O  OD1 . ASN C 1 57  ? -9.00531  -36.99888 76.86984 1.000 68.06612  ? 53  ASN C OD1 1 
ATOM   2607 N  ND2 . ASN C 1 57  ? -9.11437  -35.37191 78.41351 1.000 59.33225  ? 53  ASN C ND2 1 
ATOM   2608 N  N   . GLU C 1 58  ? -6.18473  -32.97966 76.36907 1.000 48.97409  ? 54  GLU C N   1 
ATOM   2609 C  CA  . GLU C 1 58  ? -4.79006  -32.96308 76.80035 1.000 53.19892  ? 54  GLU C CA  1 
ATOM   2610 C  C   . GLU C 1 58  ? -4.53723  -31.91342 77.87384 1.000 49.51423  ? 54  GLU C C   1 
ATOM   2611 O  O   . GLU C 1 58  ? -3.61903  -32.06699 78.68667 1.000 53.25736  ? 54  GLU C O   1 
ATOM   2612 C  CB  . GLU C 1 58  ? -3.87576  -32.71829 75.60013 1.000 46.34219  ? 54  GLU C CB  1 
ATOM   2613 C  CG  . GLU C 1 58  ? -3.55901  -33.96807 74.79575 1.000 56.46509  ? 54  GLU C CG  1 
ATOM   2614 C  CD  . GLU C 1 58  ? -2.69563  -34.95136 75.56127 1.000 65.55062  ? 54  GLU C CD  1 
ATOM   2615 O  OE1 . GLU C 1 58  ? -3.24577  -35.94114 76.08860 1.000 62.81863  ? 54  GLU C OE1 1 
ATOM   2616 O  OE2 . GLU C 1 58  ? -1.46685  -34.73667 75.63415 1.000 67.36912  ? 54  GLU C OE2 1 
ATOM   2617 N  N   . VAL C 1 59  ? -5.33541  -30.84649 77.90012 1.000 49.66945  ? 55  VAL C N   1 
ATOM   2618 C  CA  . VAL C 1 59  ? -5.17481  -29.76944 78.86262 1.000 43.33394  ? 55  VAL C CA  1 
ATOM   2619 C  C   . VAL C 1 59  ? -6.40315  -29.59915 79.74627 1.000 47.83927  ? 55  VAL C C   1 
ATOM   2620 O  O   . VAL C 1 59  ? -6.49272  -28.63033 80.49978 1.000 44.40134  ? 55  VAL C O   1 
ATOM   2621 C  CB  . VAL C 1 59  ? -4.81685  -28.44644 78.15646 1.000 47.66760  ? 55  VAL C CB  1 
ATOM   2622 C  CG1 . VAL C 1 59  ? -3.44046  -28.55312 77.53336 1.000 53.45074  ? 55  VAL C CG1 1 
ATOM   2623 C  CG2 . VAL C 1 59  ? -5.84332  -28.13311 77.09053 1.000 43.97824  ? 55  VAL C CG2 1 
ATOM   2624 N  N   . ASP C 1 60  ? -7.35424  -30.53045 79.67275 1.000 45.01505  ? 56  ASP C N   1 
ATOM   2625 C  CA  . ASP C 1 60  ? -8.53311  -30.51672 80.53796 1.000 46.74347  ? 56  ASP C CA  1 
ATOM   2626 C  C   . ASP C 1 60  ? -8.16509  -31.24460 81.82394 1.000 43.51521  ? 56  ASP C C   1 
ATOM   2627 O  O   . ASP C 1 60  ? -8.27081  -32.46737 81.92463 1.000 45.23708  ? 56  ASP C O   1 
ATOM   2628 C  CB  . ASP C 1 60  ? -9.72312  -31.16179 79.83897 1.000 38.63573  ? 56  ASP C CB  1 
ATOM   2629 C  CG  . ASP C 1 60  ? -11.03241 -30.89137 80.54821 1.000 43.42920  ? 56  ASP C CG  1 
ATOM   2630 O  OD1 . ASP C 1 60  ? -11.05095 -30.03206 81.45360 1.000 37.91863  ? 56  ASP C OD1 1 
ATOM   2631 O  OD2 . ASP C 1 60  ? -12.04387 -31.53349 80.19693 1.000 43.58901  ? 56  ASP C OD2 1 
ATOM   2632 N  N   . ALA C 1 61  ? -7.72533  -30.47747 82.82387 1.000 47.92051  ? 57  ALA C N   1 
ATOM   2633 C  CA  . ALA C 1 61  ? -7.21919  -31.07793 84.05452 1.000 46.49912  ? 57  ALA C CA  1 
ATOM   2634 C  C   . ALA C 1 61  ? -8.32906  -31.77598 84.83210 1.000 50.04792  ? 57  ALA C C   1 
ATOM   2635 O  O   . ALA C 1 61  ? -8.15258  -32.90479 85.30518 1.000 56.84956  ? 57  ALA C O   1 
ATOM   2636 C  CB  . ALA C 1 61  ? -6.54156  -30.01236 84.91712 1.000 50.11186  ? 57  ALA C CB  1 
ATOM   2637 N  N   . ASP C 1 62  ? -9.48006  -31.12212 84.97787 1.000 45.69621  ? 58  ASP C N   1 
ATOM   2638 C  CA  . ASP C 1 62  ? -10.58483 -31.69322 85.73658 1.000 46.11190  ? 58  ASP C CA  1 
ATOM   2639 C  C   . ASP C 1 62  ? -11.46576 -32.62342 84.91177 1.000 49.68655  ? 58  ASP C C   1 
ATOM   2640 O  O   . ASP C 1 62  ? -12.27065 -33.36097 85.49071 1.000 53.83327  ? 58  ASP C O   1 
ATOM   2641 C  CB  . ASP C 1 62  ? -11.43899 -30.57621 86.35072 1.000 41.82424  ? 58  ASP C CB  1 
ATOM   2642 C  CG  . ASP C 1 62  ? -11.91458 -29.56601 85.32338 1.000 39.44660  ? 58  ASP C CG  1 
ATOM   2643 O  OD1 . ASP C 1 62  ? -11.84996 -29.86033 84.11232 1.000 42.43373  ? 58  ASP C OD1 1 
ATOM   2644 O  OD2 . ASP C 1 62  ? -12.35352 -28.46994 85.72976 1.000 39.66752  ? 58  ASP C OD2 1 
ATOM   2645 N  N   . GLY C 1 63  ? -11.33754 -32.60668 83.58737 1.000 47.40338  ? 59  GLY C N   1 
ATOM   2646 C  CA  . GLY C 1 63  ? -12.09873 -33.51333 82.75070 1.000 50.46764  ? 59  GLY C CA  1 
ATOM   2647 C  C   . GLY C 1 63  ? -13.55128 -33.14503 82.55674 1.000 40.40966  ? 59  GLY C C   1 
ATOM   2648 O  O   . GLY C 1 63  ? -14.37968 -34.02993 82.31930 1.000 43.72774  ? 59  GLY C O   1 
ATOM   2649 N  N   . ASN C 1 64  ? -13.88903 -31.86010 82.64351 1.000 41.58750  ? 60  ASN C N   1 
ATOM   2650 C  CA  . ASN C 1 64  ? -15.26953 -31.42244 82.49246 1.000 44.21510  ? 60  ASN C CA  1 
ATOM   2651 C  C   . ASN C 1 64  ? -15.66511 -31.16570 81.04323 1.000 48.06647  ? 60  ASN C C   1 
ATOM   2652 O  O   . ASN C 1 64  ? -16.84764 -30.92822 80.77551 1.000 55.12605  ? 60  ASN C O   1 
ATOM   2653 C  CB  . ASN C 1 64  ? -15.51789 -30.16054 83.32749 1.000 47.95923  ? 60  ASN C CB  1 
ATOM   2654 C  CG  . ASN C 1 64  ? -14.81471 -28.94005 82.76767 1.000 39.34920  ? 60  ASN C CG  1 
ATOM   2655 O  OD1 . ASN C 1 64  ? -13.84374 -29.05461 82.01951 1.000 43.41272  ? 60  ASN C OD1 1 
ATOM   2656 N  ND2 . ASN C 1 64  ? -15.30418 -27.76042 83.12867 1.000 34.27895  ? 60  ASN C ND2 1 
ATOM   2657 N  N   . GLY C 1 65  ? -14.71603 -31.20315 80.10846 1.000 48.33216  ? 61  GLY C N   1 
ATOM   2658 C  CA  . GLY C 1 65  ? -14.99214 -31.03564 78.69737 1.000 42.21162  ? 61  GLY C CA  1 
ATOM   2659 C  C   . GLY C 1 65  ? -14.53464 -29.71499 78.11524 1.000 40.43911  ? 61  GLY C C   1 
ATOM   2660 O  O   . GLY C 1 65  ? -14.34390 -29.62648 76.89496 1.000 38.80321  ? 61  GLY C O   1 
ATOM   2661 N  N   . THR C 1 66  ? -14.36267 -28.68930 78.94101 1.000 29.96562  ? 62  THR C N   1 
ATOM   2662 C  CA  . THR C 1 66  ? -13.92217 -27.37119 78.50207 1.000 36.72358  ? 62  THR C CA  1 
ATOM   2663 C  C   . THR C 1 66  ? -12.63143 -26.99666 79.22628 1.000 27.98672  ? 62  THR C C   1 
ATOM   2664 O  O   . THR C 1 66  ? -12.10447 -27.75793 80.04008 1.000 34.11636  ? 62  THR C O   1 
ATOM   2665 C  CB  . THR C 1 66  ? -15.00917 -26.31857 78.74428 1.000 33.74472  ? 62  THR C CB  1 
ATOM   2666 O  OG1 . THR C 1 66  ? -15.23442 -26.17527 80.15245 1.000 42.62394  ? 62  THR C OG1 1 
ATOM   2667 C  CG2 . THR C 1 66  ? -16.31034 -26.72771 78.06751 1.000 28.71404  ? 62  THR C CG2 1 
ATOM   2668 N  N   . ILE C 1 67  ? -12.12265 -25.80462 78.92441 1.000 30.65130  ? 63  ILE C N   1 
ATOM   2669 C  CA  . ILE C 1 67  ? -10.86184 -25.32483 79.47903 1.000 35.07561  ? 63  ILE C CA  1 
ATOM   2670 C  C   . ILE C 1 67  ? -11.09691 -23.96014 80.10561 1.000 33.13908  ? 63  ILE C C   1 
ATOM   2671 O  O   . ILE C 1 67  ? -11.45511 -23.00526 79.40552 1.000 40.75885  ? 63  ILE C O   1 
ATOM   2672 C  CB  . ILE C 1 67  ? -9.75779  -25.24219 78.41310 1.000 32.20231  ? 63  ILE C CB  1 
ATOM   2673 C  CG1 . ILE C 1 67  ? -9.33073  -26.64468 77.98986 1.000 29.83962  ? 63  ILE C CG1 1 
ATOM   2674 C  CG2 . ILE C 1 67  ? -8.56512  -24.45211 78.93625 1.000 30.16327  ? 63  ILE C CG2 1 
ATOM   2675 C  CD1 . ILE C 1 67  ? -9.00022  -26.74729 76.53530 1.000 35.07342  ? 63  ILE C CD1 1 
ATOM   2676 N  N   . ASP C 1 68  ? -10.89628 -23.86736 81.41495 1.000 29.47779  ? 64  ASP C N   1 
ATOM   2677 C  CA  . ASP C 1 68  ? -10.93481 -22.58683 82.09872 1.000 35.99204  ? 64  ASP C CA  1 
ATOM   2678 C  C   . ASP C 1 68  ? -9.56667  -21.91423 82.02272 1.000 29.14319  ? 64  ASP C C   1 
ATOM   2679 O  O   . ASP C 1 68  ? -8.59180  -22.48256 81.52658 1.000 40.59141  ? 64  ASP C O   1 
ATOM   2680 C  CB  . ASP C 1 68  ? -11.37701 -22.76568 83.55189 1.000 43.71050  ? 64  ASP C CB  1 
ATOM   2681 C  CG  . ASP C 1 68  ? -10.64945 -23.90046 84.25260 1.000 40.79943  ? 64  ASP C CG  1 
ATOM   2682 O  OD1 . ASP C 1 68  ? -9.41498  -24.01341 84.09726 1.000 36.84503  ? 64  ASP C OD1 1 
ATOM   2683 O  OD2 . ASP C 1 68  ? -11.31714 -24.68348 84.95997 1.000 45.14343  ? 64  ASP C OD2 1 
ATOM   2684 N  N   . PHE C 1 69  ? -9.50210  -20.68232 82.52297 1.000 27.63784  ? 65  PHE C N   1 
ATOM   2685 C  CA  . PHE C 1 69  ? -8.23591  -19.95497 82.50142 1.000 35.20194  ? 65  PHE C CA  1 
ATOM   2686 C  C   . PHE C 1 69  ? -7.14222  -20.61412 83.33509 1.000 37.79287  ? 65  PHE C C   1 
ATOM   2687 O  O   . PHE C 1 69  ? -5.97957  -20.59364 82.89094 1.000 37.97162  ? 65  PHE C O   1 
ATOM   2688 C  CB  . PHE C 1 69  ? -8.45546  -18.50333 82.94565 1.000 37.14158  ? 65  PHE C CB  1 
ATOM   2689 C  CG  . PHE C 1 69  ? -7.19335  -17.68891 82.97912 1.000 47.32125  ? 65  PHE C CG  1 
ATOM   2690 C  CD1 . PHE C 1 69  ? -6.61410  -17.32984 84.18454 1.000 44.95150  ? 65  PHE C CD1 1 
ATOM   2691 C  CD2 . PHE C 1 69  ? -6.57690  -17.29553 81.80173 1.000 46.79067  ? 65  PHE C CD2 1 
ATOM   2692 C  CE1 . PHE C 1 69  ? -5.45035  -16.58495 84.21716 1.000 40.57654  ? 65  PHE C CE1 1 
ATOM   2693 C  CE2 . PHE C 1 69  ? -5.41078  -16.55196 81.82788 1.000 47.96309  ? 65  PHE C CE2 1 
ATOM   2694 C  CZ  . PHE C 1 69  ? -4.84819  -16.19545 83.03724 1.000 44.28317  ? 65  PHE C CZ  1 
ATOM   2695 N  N   . PRO C 1 70  ? -7.40815  -21.17866 84.52292 1.000 40.96981  ? 66  PRO C N   1 
ATOM   2696 C  CA  . PRO C 1 70  ? -6.33375  -21.90017 85.22707 1.000 44.11735  ? 66  PRO C CA  1 
ATOM   2697 C  C   . PRO C 1 70  ? -5.70817  -23.00799 84.39888 1.000 40.65131  ? 66  PRO C C   1 
ATOM   2698 O  O   . PRO C 1 70  ? -4.47829  -23.14025 84.37743 1.000 41.52858  ? 66  PRO C O   1 
ATOM   2699 C  CB  . PRO C 1 70  ? -7.05062  -22.44963 86.46526 1.000 38.57785  ? 66  PRO C CB  1 
ATOM   2700 C  CG  . PRO C 1 70  ? -8.07255  -21.41498 86.75411 1.000 35.26906  ? 66  PRO C CG  1 
ATOM   2701 C  CD  . PRO C 1 70  ? -8.58730  -21.00410 85.39481 1.000 38.45312  ? 66  PRO C CD  1 
ATOM   2702 N  N   . GLU C 1 71  ? -6.52426  -23.81291 83.71436 1.000 43.70247  ? 67  GLU C N   1 
ATOM   2703 C  CA  . GLU C 1 71  ? -5.97758  -24.83524 82.82816 1.000 43.55655  ? 67  GLU C CA  1 
ATOM   2704 C  C   . GLU C 1 71  ? -5.26485  -24.20276 81.64023 1.000 38.30925  ? 67  GLU C C   1 
ATOM   2705 O  O   . GLU C 1 71  ? -4.24352  -24.71979 81.17332 1.000 38.30451  ? 67  GLU C O   1 
ATOM   2706 C  CB  . GLU C 1 71  ? -7.09181  -25.76923 82.35652 1.000 37.69933  ? 67  GLU C CB  1 
ATOM   2707 C  CG  . GLU C 1 71  ? -7.57193  -26.74552 83.41827 1.000 32.24147  ? 67  GLU C CG  1 
ATOM   2708 C  CD  . GLU C 1 71  ? -8.94874  -27.30287 83.11555 1.000 43.59172  ? 67  GLU C CD  1 
ATOM   2709 O  OE1 . GLU C 1 71  ? -9.51640  -26.94033 82.06439 1.000 40.38775  ? 67  GLU C OE1 1 
ATOM   2710 O  OE2 . GLU C 1 71  ? -9.46445  -28.09990 83.92778 1.000 37.92400  ? 67  GLU C OE2 1 
ATOM   2711 N  N   . PHE C 1 72  ? -5.79220  -23.08302 81.14148 1.000 39.94690  ? 68  PHE C N   1 
ATOM   2712 C  CA  . PHE C 1 72  ? -5.12935  -22.34909 80.06825 1.000 42.90784  ? 68  PHE C CA  1 
ATOM   2713 C  C   . PHE C 1 72  ? -3.77740  -21.81583 80.52710 1.000 44.29497  ? 68  PHE C C   1 
ATOM   2714 O  O   . PHE C 1 72  ? -2.76807  -21.95867 79.82650 1.000 46.27896  ? 68  PHE C O   1 
ATOM   2715 C  CB  . PHE C 1 72  ? -6.03417  -21.20885 79.59555 1.000 38.81964  ? 68  PHE C CB  1 
ATOM   2716 C  CG  . PHE C 1 72  ? -5.58945  -20.56113 78.31501 1.000 42.68626  ? 68  PHE C CG  1 
ATOM   2717 C  CD1 . PHE C 1 72  ? -4.72492  -19.47902 78.33560 1.000 42.26883  ? 68  PHE C CD1 1 
ATOM   2718 C  CD2 . PHE C 1 72  ? -6.04680  -21.02346 77.09186 1.000 44.91973  ? 68  PHE C CD2 1 
ATOM   2719 C  CE1 . PHE C 1 72  ? -4.31787  -18.87511 77.16082 1.000 44.40113  ? 68  PHE C CE1 1 
ATOM   2720 C  CE2 . PHE C 1 72  ? -5.64303  -20.42355 75.91234 1.000 36.76472  ? 68  PHE C CE2 1 
ATOM   2721 C  CZ  . PHE C 1 72  ? -4.77647  -19.34870 75.94760 1.000 40.33976  ? 68  PHE C CZ  1 
ATOM   2722 N  N   . LEU C 1 73  ? -3.74186  -21.20024 81.71236 1.000 40.91306  ? 69  LEU C N   1 
ATOM   2723 C  CA  . LEU C 1 73  ? -2.49385  -20.65774 82.24045 1.000 43.16380  ? 69  LEU C CA  1 
ATOM   2724 C  C   . LEU C 1 73  ? -1.45086  -21.75153 82.43283 1.000 42.51877  ? 69  LEU C C   1 
ATOM   2725 O  O   . LEU C 1 73  ? -0.25332  -21.52100 82.22724 1.000 46.03699  ? 69  LEU C O   1 
ATOM   2726 C  CB  . LEU C 1 73  ? -2.76202  -19.93281 83.55975 1.000 42.01325  ? 69  LEU C CB  1 
ATOM   2727 C  CG  . LEU C 1 73  ? -1.66742  -19.01422 84.10531 1.000 42.34597  ? 69  LEU C CG  1 
ATOM   2728 C  CD1 . LEU C 1 73  ? -1.51586  -17.78231 83.23104 1.000 41.50089  ? 69  LEU C CD1 1 
ATOM   2729 C  CD2 . LEU C 1 73  ? -1.97546  -18.61814 85.54060 1.000 34.28350  ? 69  LEU C CD2 1 
ATOM   2730 N  N   . THR C 1 74  ? -1.88716  -22.95081 82.82424 1.000 41.75626  ? 70  THR C N   1 
ATOM   2731 C  CA  . THR C 1 74  ? -0.95136  -24.05387 83.02162 1.000 47.46133  ? 70  THR C CA  1 
ATOM   2732 C  C   . THR C 1 74  ? -0.32008  -24.48469 81.70237 1.000 49.81968  ? 70  THR C C   1 
ATOM   2733 O  O   . THR C 1 74  ? 0.90764   -24.59183 81.59589 1.000 47.96788  ? 70  THR C O   1 
ATOM   2734 C  CB  . THR C 1 74  ? -1.66001  -25.23406 83.68625 1.000 43.94835  ? 70  THR C CB  1 
ATOM   2735 O  OG1 . THR C 1 74  ? -2.28937  -24.79622 84.89753 1.000 44.01915  ? 70  THR C OG1 1 
ATOM   2736 C  CG2 . THR C 1 74  ? -0.66135  -26.33749 84.00710 1.000 39.13738  ? 70  THR C CG2 1 
HETATM 2737 N  N   . MSE C 1 75  ? -1.14347  -24.74313 80.68998 1.000 44.96699  ? 71  MSE C N   1 
HETATM 2738 C  CA  . MSE C 1 75  ? -0.65140  -25.12260 79.36703 1.000 58.94008  ? 71  MSE C CA  1 
HETATM 2739 C  C   . MSE C 1 75  ? 0.23343   -24.05266 78.73049 1.000 49.91842  ? 71  MSE C C   1 
HETATM 2740 O  O   . MSE C 1 75  ? 1.24913   -24.36435 78.10316 1.000 46.58734  ? 71  MSE C O   1 
HETATM 2741 C  CB  . MSE C 1 75  ? -1.83707  -25.45987 78.45387 1.000 45.08010  ? 71  MSE C CB  1 
HETATM 2742 C  CG  . MSE C 1 75  ? -1.61710  -25.20212 76.96849 1.000 50.95316  ? 71  MSE C CG  1 
HETATM 2743 SE SE  . MSE C 1 75  ? -3.29515  -25.32834 75.97448 1.000 101.25485 ? 71  MSE C SE  1 
HETATM 2744 C  CE  . MSE C 1 75  ? -3.67591  -23.43793 75.70649 1.000 60.11055  ? 71  MSE C CE  1 
HETATM 2745 N  N   . MSE C 1 76  ? -0.14230  -22.79235 78.90983 1.000 49.28027  ? 72  MSE C N   1 
HETATM 2746 C  CA  . MSE C 1 76  ? 0.60464   -21.68538 78.32102 1.000 59.42554  ? 72  MSE C CA  1 
HETATM 2747 C  C   . MSE C 1 76  ? 1.86837   -21.32790 79.10658 1.000 57.34820  ? 72  MSE C C   1 
HETATM 2748 O  O   . MSE C 1 76  ? 2.59782   -20.39869 78.75235 1.000 56.30287  ? 72  MSE C O   1 
HETATM 2749 C  CB  . MSE C 1 76  ? -0.32340  -20.48364 78.16209 1.000 52.73775  ? 72  MSE C CB  1 
HETATM 2750 C  CG  . MSE C 1 76  ? -1.33211  -20.71604 77.05936 1.000 61.97903  ? 72  MSE C CG  1 
HETATM 2751 SE SE  . MSE C 1 76  ? -0.48937  -20.22047 75.37787 1.000 94.39706  ? 72  MSE C SE  1 
HETATM 2752 C  CE  . MSE C 1 76  ? -0.15305  -22.00966 74.68859 1.000 82.60175  ? 72  MSE C CE  1 
ATOM   2753 N  N   . ALA C 1 77  ? 2.13018   -22.10129 80.16084 1.000 54.72488  ? 73  ALA C N   1 
ATOM   2754 C  CA  . ALA C 1 77  ? 3.42720   -22.12145 80.82976 1.000 62.36499  ? 73  ALA C CA  1 
ATOM   2755 C  C   . ALA C 1 77  ? 4.27490   -23.29543 80.34807 1.000 56.90923  ? 73  ALA C C   1 
ATOM   2756 O  O   . ALA C 1 77  ? 5.33597   -23.09841 79.74739 1.000 56.71146  ? 73  ALA C O   1 
ATOM   2757 C  CB  . ALA C 1 77  ? 3.23334   -22.18102 82.35234 1.000 60.78345  ? 73  ALA C CB  1 
ATOM   2758 N  N   . ARG C 1 78  ? 3.81374   -24.51965 80.59544 1.000 54.39432  ? 74  ARG C N   1 
ATOM   2759 C  CA  . ARG C 1 78  ? 4.48256   -25.72240 80.10395 1.000 49.67473  ? 74  ARG C CA  1 
ATOM   2760 C  C   . ARG C 1 78  ? 3.54465   -26.92651 80.12918 1.000 63.14979  ? 74  ARG C C   1 
ATOM   2761 O  O   . ARG C 1 78  ? 3.29045   -27.55173 79.09780 1.000 58.65484  ? 74  ARG C O   1 
ATOM   2762 C  CB  . ARG C 1 78  ? 5.73376   -26.02001 80.92884 1.000 73.30705  ? 74  ARG C CB  1 
ATOM   2763 N  N   . SER C 1 85  ? 8.44212   -31.18319 68.21700 1.000 64.70853  ? 81  SER C N   1 
ATOM   2764 C  CA  . SER C 1 85  ? 7.70152   -30.91967 66.98899 1.000 61.25007  ? 81  SER C CA  1 
ATOM   2765 C  C   . SER C 1 85  ? 7.97303   -29.51648 66.45701 1.000 51.71772  ? 81  SER C C   1 
ATOM   2766 O  O   . SER C 1 85  ? 7.20972   -28.58430 66.71774 1.000 49.41881  ? 81  SER C O   1 
ATOM   2767 C  CB  . SER C 1 85  ? 6.19988   -31.10825 67.21653 1.000 39.75473  ? 81  SER C CB  1 
ATOM   2768 O  OG  . SER C 1 85  ? 5.47565   -30.91790 66.01288 1.000 55.09095  ? 81  SER C OG  1 
ATOM   2769 N  N   . GLU C 1 86  ? 9.07115   -29.37274 65.71040 1.000 48.77556  ? 82  GLU C N   1 
ATOM   2770 C  CA  . GLU C 1 86  ? 9.35369   -28.11371 65.03227 1.000 51.33114  ? 82  GLU C CA  1 
ATOM   2771 C  C   . GLU C 1 86  ? 8.36224   -27.83858 63.91105 1.000 47.23684  ? 82  GLU C C   1 
ATOM   2772 O  O   . GLU C 1 86  ? 8.20178   -26.68012 63.51091 1.000 41.44429  ? 82  GLU C O   1 
ATOM   2773 C  CB  . GLU C 1 86  ? 10.77552  -28.12452 64.46916 1.000 47.92172  ? 82  GLU C CB  1 
ATOM   2774 C  CG  . GLU C 1 86  ? 11.03615  -29.26838 63.50385 1.000 53.49793  ? 82  GLU C CG  1 
ATOM   2775 C  CD  . GLU C 1 86  ? 12.50988  -29.49627 63.24625 1.000 50.26309  ? 82  GLU C CD  1 
ATOM   2776 O  OE1 . GLU C 1 86  ? 13.14574  -28.62945 62.60973 1.000 51.63623  ? 82  GLU C OE1 1 
ATOM   2777 O  OE2 . GLU C 1 86  ? 13.03235  -30.54489 63.67912 1.000 56.23229  ? 82  GLU C OE2 1 
ATOM   2778 N  N   . GLU C 1 87  ? 7.69887   -28.87995 63.40023 1.000 35.28296  ? 83  GLU C N   1 
ATOM   2779 C  CA  . GLU C 1 87  ? 6.71897   -28.69670 62.33494 1.000 40.54842  ? 83  GLU C CA  1 
ATOM   2780 C  C   . GLU C 1 87  ? 5.57609   -27.78864 62.77378 1.000 45.92591  ? 83  GLU C C   1 
ATOM   2781 O  O   . GLU C 1 87  ? 5.05577   -27.00761 61.96961 1.000 41.04496  ? 83  GLU C O   1 
ATOM   2782 C  CB  . GLU C 1 87  ? 6.18125   -30.05412 61.87932 1.000 44.56049  ? 83  GLU C CB  1 
ATOM   2783 C  CG  . GLU C 1 87  ? 5.20898   -29.99317 60.70660 1.000 35.38381  ? 83  GLU C CG  1 
ATOM   2784 C  CD  . GLU C 1 87  ? 5.67062   -29.06472 59.59722 1.000 40.39564  ? 83  GLU C CD  1 
ATOM   2785 O  OE1 . GLU C 1 87  ? 6.85649   -29.13347 59.20814 1.000 40.26260  ? 83  GLU C OE1 1 
ATOM   2786 O  OE2 . GLU C 1 87  ? 4.84214   -28.26835 59.10668 1.000 43.80384  ? 83  GLU C OE2 1 
ATOM   2787 N  N   . GLU C 1 88  ? 5.16356   -27.87507 64.04133 1.000 42.22659  ? 84  GLU C N   1 
ATOM   2788 C  CA  . GLU C 1 88  ? 4.08994   -27.00093 64.50613 1.000 41.72115  ? 84  GLU C CA  1 
ATOM   2789 C  C   . GLU C 1 88  ? 4.53761   -25.54607 64.54218 1.000 33.49486  ? 84  GLU C C   1 
ATOM   2790 O  O   . GLU C 1 88  ? 3.76954   -24.64975 64.17802 1.000 34.91391  ? 84  GLU C O   1 
ATOM   2791 C  CB  . GLU C 1 88  ? 3.58495   -27.43680 65.88391 1.000 45.11480  ? 84  GLU C CB  1 
ATOM   2792 C  CG  . GLU C 1 88  ? 2.55137   -26.48337 66.50798 1.000 52.95899  ? 84  GLU C CG  1 
ATOM   2793 C  CD  . GLU C 1 88  ? 1.41528   -26.07766 65.57126 1.000 63.37461  ? 84  GLU C CD  1 
ATOM   2794 O  OE1 . GLU C 1 88  ? 1.11206   -26.80934 64.61080 1.000 62.45786  ? 84  GLU C OE1 1 
ATOM   2795 O  OE2 . GLU C 1 88  ? 0.85700   -24.97653 65.76515 1.000 64.94412  ? 84  GLU C OE2 1 
ATOM   2796 N  N   . ILE C 1 89  ? 5.77390   -25.28933 64.97289 1.000 41.62364  ? 85  ILE C N   1 
ATOM   2797 C  CA  . ILE C 1 89  ? 6.29578   -23.92686 64.92892 1.000 40.39176  ? 85  ILE C CA  1 
ATOM   2798 C  C   . ILE C 1 89  ? 6.43933   -23.46454 63.48458 1.000 33.73939  ? 85  ILE C C   1 
ATOM   2799 O  O   . ILE C 1 89  ? 6.13590   -22.31150 63.15526 1.000 35.28865  ? 85  ILE C O   1 
ATOM   2800 C  CB  . ILE C 1 89  ? 7.62770   -23.83419 65.69719 1.000 35.02298  ? 85  ILE C CB  1 
ATOM   2801 C  CG1 . ILE C 1 89  ? 7.40686   -24.14846 67.17876 1.000 37.03296  ? 85  ILE C CG1 1 
ATOM   2802 C  CG2 . ILE C 1 89  ? 8.23584   -22.44507 65.55485 1.000 25.06972  ? 85  ILE C CG2 1 
ATOM   2803 C  CD1 . ILE C 1 89  ? 8.21496   -25.32302 67.67798 1.000 41.01322  ? 85  ILE C CD1 1 
ATOM   2804 N  N   . ARG C 1 90  ? 6.88867   -24.35959 62.59949 1.000 34.98117  ? 86  ARG C N   1 
ATOM   2805 C  CA  . ARG C 1 90  ? 6.93367   -24.04797 61.17328 1.000 37.47122  ? 86  ARG C CA  1 
ATOM   2806 C  C   . ARG C 1 90  ? 5.54488   -23.71550 60.64541 1.000 32.93538  ? 86  ARG C C   1 
ATOM   2807 O  O   . ARG C 1 90  ? 5.36123   -22.73400 59.91617 1.000 34.54744  ? 86  ARG C O   1 
ATOM   2808 C  CB  . ARG C 1 90  ? 7.52185   -25.22538 60.39274 1.000 42.99065  ? 86  ARG C CB  1 
ATOM   2809 C  CG  . ARG C 1 90  ? 8.90085   -24.97978 59.80956 1.000 40.10791  ? 86  ARG C CG  1 
ATOM   2810 C  CD  . ARG C 1 90  ? 9.96031   -25.20739 60.86416 1.000 47.60230  ? 86  ARG C CD  1 
ATOM   2811 N  NE  . ARG C 1 90  ? 11.30739  -24.92770 60.38235 1.000 47.80588  ? 86  ARG C NE  1 
ATOM   2812 C  CZ  . ARG C 1 90  ? 12.40216  -25.52078 60.83879 1.000 49.69601  ? 86  ARG C CZ  1 
ATOM   2813 N  NH1 . ARG C 1 90  ? 12.34726  -26.42581 61.80253 1.000 47.26212  ? 86  ARG C NH1 1 
ATOM   2814 N  NH2 . ARG C 1 90  ? 13.58235  -25.19154 60.32121 1.000 37.51345  ? 86  ARG C NH2 1 
ATOM   2815 N  N   . GLU C 1 91  ? 4.55328   -24.53535 61.00129 1.000 35.75916  ? 87  GLU C N   1 
ATOM   2816 C  CA  . GLU C 1 91  ? 3.18817   -24.30321 60.54184 1.000 44.57236  ? 87  GLU C CA  1 
ATOM   2817 C  C   . GLU C 1 91  ? 2.65329   -22.97736 61.06686 1.000 30.87604  ? 87  GLU C C   1 
ATOM   2818 O  O   . GLU C 1 91  ? 2.08717   -22.17950 60.31100 1.000 32.18163  ? 87  GLU C O   1 
ATOM   2819 C  CB  . GLU C 1 91  ? 2.28838   -25.46087 60.97643 1.000 34.01856  ? 87  GLU C CB  1 
ATOM   2820 C  CG  . GLU C 1 91  ? 0.85000   -25.33999 60.50247 1.000 41.76432  ? 87  GLU C CG  1 
ATOM   2821 C  CD  . GLU C 1 91  ? 0.74854   -25.05951 59.01598 1.000 40.59305  ? 87  GLU C CD  1 
ATOM   2822 O  OE1 . GLU C 1 91  ? 1.37616   -25.79520 58.22463 1.000 49.19575  ? 87  GLU C OE1 1 
ATOM   2823 O  OE2 . GLU C 1 91  ? 0.04259   -24.10119 58.63787 1.000 40.36797  ? 87  GLU C OE2 1 
ATOM   2824 N  N   . ALA C 1 92  ? 2.82993   -22.72298 62.36627 1.000 33.88318  ? 88  ALA C N   1 
ATOM   2825 C  CA  . ALA C 1 92  ? 2.38669   -21.45572 62.93609 1.000 36.29464  ? 88  ALA C CA  1 
ATOM   2826 C  C   . ALA C 1 92  ? 3.15346   -20.28006 62.34708 1.000 30.32456  ? 88  ALA C C   1 
ATOM   2827 O  O   . ALA C 1 92  ? 2.60075   -19.18213 62.21818 1.000 28.02224  ? 88  ALA C O   1 
ATOM   2828 C  CB  . ALA C 1 92  ? 2.53443   -21.48078 64.45743 1.000 36.37239  ? 88  ALA C CB  1 
ATOM   2829 N  N   . PHE C 1 93  ? 4.42056   -20.48785 61.98031 1.000 28.47185  ? 89  PHE C N   1 
ATOM   2830 C  CA  . PHE C 1 93  ? 5.18485   -19.42080 61.34268 1.000 30.59713  ? 89  PHE C CA  1 
ATOM   2831 C  C   . PHE C 1 93  ? 4.63057   -19.09729 59.96121 1.000 28.44150  ? 89  PHE C C   1 
ATOM   2832 O  O   . PHE C 1 93  ? 4.53857   -17.92364 59.58331 1.000 23.51892  ? 89  PHE C O   1 
ATOM   2833 C  CB  . PHE C 1 93  ? 6.66036   -19.80992 61.25142 1.000 23.59536  ? 89  PHE C CB  1 
ATOM   2834 C  CG  . PHE C 1 93  ? 7.53634   -18.72995 60.68650 1.000 23.29199  ? 89  PHE C CG  1 
ATOM   2835 C  CD1 . PHE C 1 93  ? 7.98626   -17.69340 61.48722 1.000 20.71961  ? 89  PHE C CD1 1 
ATOM   2836 C  CD2 . PHE C 1 93  ? 7.90502   -18.74809 59.35197 1.000 25.44236  ? 89  PHE C CD2 1 
ATOM   2837 C  CE1 . PHE C 1 93  ? 8.79185   -16.69784 60.96773 1.000 22.51115  ? 89  PHE C CE1 1 
ATOM   2838 C  CE2 . PHE C 1 93  ? 8.70856   -17.75482 58.82666 1.000 33.25797  ? 89  PHE C CE2 1 
ATOM   2839 C  CZ  . PHE C 1 93  ? 9.15264   -16.72868 59.63642 1.000 20.23048  ? 89  PHE C CZ  1 
ATOM   2840 N  N   . ARG C 1 94  ? 4.25681   -20.12663 59.19438 1.000 32.16902  ? 90  ARG C N   1 
ATOM   2841 C  CA  . ARG C 1 94  ? 3.67716   -19.90330 57.87376 1.000 35.42224  ? 90  ARG C CA  1 
ATOM   2842 C  C   . ARG C 1 94  ? 2.35753   -19.15342 57.96873 1.000 25.53187  ? 90  ARG C C   1 
ATOM   2843 O  O   . ARG C 1 94  ? 1.97127   -18.45299 57.02584 1.000 33.33051  ? 90  ARG C O   1 
ATOM   2844 C  CB  . ARG C 1 94  ? 3.46788   -21.23892 57.15800 1.000 42.22161  ? 90  ARG C CB  1 
ATOM   2845 C  CG  . ARG C 1 94  ? 4.74359   -21.88116 56.64426 1.000 34.50834  ? 90  ARG C CG  1 
ATOM   2846 C  CD  . ARG C 1 94  ? 4.44673   -23.14234 55.84487 1.000 43.75605  ? 90  ARG C CD  1 
ATOM   2847 N  NE  . ARG C 1 94  ? 4.12633   -24.27093 56.71286 1.000 49.48261  ? 90  ARG C NE  1 
ATOM   2848 C  CZ  . ARG C 1 94  ? 4.98824   -25.21450 57.07079 1.000 42.15486  ? 90  ARG C CZ  1 
ATOM   2849 N  NH1 . ARG C 1 94  ? 6.25244   -25.17863 56.68748 1.000 37.11299  ? 90  ARG C NH1 1 
ATOM   2850 N  NH2 . ARG C 1 94  ? 4.57383   -26.21600 57.84112 1.000 40.46845  ? 90  ARG C NH2 1 
ATOM   2851 N  N   . VAL C 1 95  ? 1.65420   -19.29310 59.09497 1.000 29.27949  ? 91  VAL C N   1 
ATOM   2852 C  CA  . VAL C 1 95  ? 0.38893   -18.59437 59.28406 1.000 29.55789  ? 91  VAL C CA  1 
ATOM   2853 C  C   . VAL C 1 95  ? 0.61817   -17.09083 59.35586 1.000 29.69894  ? 91  VAL C C   1 
ATOM   2854 O  O   . VAL C 1 95  ? -0.19476  -16.30420 58.85444 1.000 28.95648  ? 91  VAL C O   1 
ATOM   2855 C  CB  . VAL C 1 95  ? -0.31593  -19.13350 60.54377 1.000 35.90556  ? 91  VAL C CB  1 
ATOM   2856 C  CG1 . VAL C 1 95  ? -1.30123  -18.11166 61.10925 1.000 38.40972  ? 91  VAL C CG1 1 
ATOM   2857 C  CG2 . VAL C 1 95  ? -0.99463  -20.46350 60.24457 1.000 38.68639  ? 91  VAL C CG2 1 
ATOM   2858 N  N   . PHE C 1 96  ? 1.73076   -16.66423 59.95468 1.000 31.76606  ? 92  PHE C N   1 
ATOM   2859 C  CA  . PHE C 1 96  ? 2.05232   -15.24263 59.98498 1.000 30.17545  ? 92  PHE C CA  1 
ATOM   2860 C  C   . PHE C 1 96  ? 2.76164   -14.80626 58.70880 1.000 23.54004  ? 92  PHE C C   1 
ATOM   2861 O  O   . PHE C 1 96  ? 2.47949   -13.72678 58.17761 1.000 28.54509  ? 92  PHE C O   1 
ATOM   2862 C  CB  . PHE C 1 96  ? 2.91081   -14.92358 61.20986 1.000 26.33326  ? 92  PHE C CB  1 
ATOM   2863 C  CG  . PHE C 1 96  ? 2.20603   -15.13820 62.51883 1.000 28.67457  ? 92  PHE C CG  1 
ATOM   2864 C  CD1 . PHE C 1 96  ? 1.30102   -14.20549 62.99747 1.000 32.19856  ? 92  PHE C CD1 1 
ATOM   2865 C  CD2 . PHE C 1 96  ? 2.44997   -16.27461 63.27050 1.000 29.04561  ? 92  PHE C CD2 1 
ATOM   2866 C  CE1 . PHE C 1 96  ? 0.65346   -14.40340 64.20354 1.000 38.95903  ? 92  PHE C CE1 1 
ATOM   2867 C  CE2 . PHE C 1 96  ? 1.80528   -16.47778 64.47477 1.000 35.92093  ? 92  PHE C CE2 1 
ATOM   2868 C  CZ  . PHE C 1 96  ? 0.90619   -15.54138 64.94107 1.000 39.96147  ? 92  PHE C CZ  1 
ATOM   2869 N  N   . ASP C 1 97  ? 3.67876   -15.63191 58.20447 1.000 28.85812  ? 93  ASP C N   1 
ATOM   2870 C  CA  . ASP C 1 97  ? 4.44477   -15.31628 56.99736 1.000 26.99831  ? 93  ASP C CA  1 
ATOM   2871 C  C   . ASP C 1 97  ? 3.64375   -15.72850 55.76090 1.000 27.40916  ? 93  ASP C C   1 
ATOM   2872 O  O   . ASP C 1 97  ? 3.93956   -16.70881 55.07599 1.000 31.18776  ? 93  ASP C O   1 
ATOM   2873 C  CB  . ASP C 1 97  ? 5.80456   -16.00205 57.04387 1.000 29.85106  ? 93  ASP C CB  1 
ATOM   2874 C  CG  . ASP C 1 97  ? 6.70810   -15.58726 55.90114 1.000 26.23956  ? 93  ASP C CG  1 
ATOM   2875 O  OD1 . ASP C 1 97  ? 6.51489   -14.47886 55.36059 1.000 27.57344  ? 93  ASP C OD1 1 
ATOM   2876 O  OD2 . ASP C 1 97  ? 7.60875   -16.37459 55.54137 1.000 27.82166  ? 93  ASP C OD2 1 
ATOM   2877 N  N   . LYS C 1 98  ? 2.60822   -14.93497 55.47579 1.000 27.31845  ? 94  LYS C N   1 
ATOM   2878 C  CA  . LYS C 1 98  ? 1.68269   -15.28937 54.40334 1.000 31.50422  ? 94  LYS C CA  1 
ATOM   2879 C  C   . LYS C 1 98  ? 2.31043   -15.09552 53.02713 1.000 29.97064  ? 94  LYS C C   1 
ATOM   2880 O  O   . LYS C 1 98  ? 2.04595   -15.87790 52.10660 1.000 33.46720  ? 94  LYS C O   1 
ATOM   2881 C  CB  . LYS C 1 98  ? 0.39220   -14.48045 54.53493 1.000 29.43613  ? 94  LYS C CB  1 
ATOM   2882 C  CG  . LYS C 1 98  ? -0.44989  -14.88796 55.73311 1.000 28.38747  ? 94  LYS C CG  1 
ATOM   2883 C  CD  . LYS C 1 98  ? -1.67280  -15.68107 55.29607 1.000 36.08129  ? 94  LYS C CD  1 
ATOM   2884 C  CE  . LYS C 1 98  ? -2.10215  -16.67888 56.36366 1.000 37.93906  ? 94  LYS C CE  1 
ATOM   2885 N  NZ  . LYS C 1 98  ? -2.92834  -16.05919 57.43996 1.000 36.27347  ? 94  LYS C NZ  1 
ATOM   2886 N  N   . ASP C 1 99  ? 3.13843   -14.06500 52.85787 1.000 29.32659  ? 95  ASP C N   1 
ATOM   2887 C  CA  . ASP C 1 99  ? 3.84755   -13.90687 51.59384 1.000 25.09130  ? 95  ASP C CA  1 
ATOM   2888 C  C   . ASP C 1 99  ? 5.06902   -14.81328 51.48762 1.000 24.95029  ? 95  ASP C C   1 
ATOM   2889 O  O   . ASP C 1 99  ? 5.71109   -14.84091 50.43182 1.000 20.82620  ? 95  ASP C O   1 
ATOM   2890 C  CB  . ASP C 1 99  ? 4.23765   -12.43796 51.37541 1.000 30.39184  ? 95  ASP C CB  1 
ATOM   2891 C  CG  . ASP C 1 99  ? 5.32686   -11.95604 52.32196 1.000 34.71189  ? 95  ASP C CG  1 
ATOM   2892 O  OD1 . ASP C 1 99  ? 5.72042   -12.69889 53.24671 1.000 32.20964  ? 95  ASP C OD1 1 
ATOM   2893 O  OD2 . ASP C 1 99  ? 5.79229   -10.81340 52.13236 1.000 31.46590  ? 95  ASP C OD2 1 
ATOM   2894 N  N   . GLY C 1 100 ? 5.40022   -15.54656 52.55029 1.000 22.36772  ? 96  GLY C N   1 
ATOM   2895 C  CA  . GLY C 1 100 ? 6.42803   -16.56791 52.50238 1.000 26.61310  ? 96  GLY C CA  1 
ATOM   2896 C  C   . GLY C 1 100 ? 7.85024   -16.07579 52.37238 1.000 29.37082  ? 96  GLY C C   1 
ATOM   2897 O  O   . GLY C 1 100 ? 8.74556   -16.88783 52.12270 1.000 20.91275  ? 96  GLY C O   1 
ATOM   2898 N  N   . ASN C 1 101 ? 8.09847   -14.77906 52.54422 1.000 28.30540  ? 97  ASN C N   1 
ATOM   2899 C  CA  . ASN C 1 101 ? 9.44380   -14.24725 52.36459 1.000 26.92925  ? 97  ASN C CA  1 
ATOM   2900 C  C   . ASN C 1 101 ? 10.36766  -14.53739 53.54208 1.000 27.31816  ? 97  ASN C C   1 
ATOM   2901 O  O   . ASN C 1 101 ? 11.53447  -14.13248 53.50328 1.000 28.65089  ? 97  ASN C O   1 
ATOM   2902 C  CB  . ASN C 1 101 ? 9.38206   -12.73832 52.10343 1.000 22.59688  ? 97  ASN C CB  1 
ATOM   2903 C  CG  . ASN C 1 101 ? 9.20533   -11.92863 53.37305 1.000 27.01053  ? 97  ASN C CG  1 
ATOM   2904 O  OD1 . ASN C 1 101 ? 8.47902   -12.32755 54.28401 1.000 29.75275  ? 97  ASN C OD1 1 
ATOM   2905 N  ND2 . ASN C 1 101 ? 9.86836   -10.77966 53.43723 1.000 30.74569  ? 97  ASN C ND2 1 
ATOM   2906 N  N   . GLY C 1 102 ? 9.88682   -15.22420 54.57564 1.000 21.78540  ? 98  GLY C N   1 
ATOM   2907 C  CA  . GLY C 1 102 ? 10.71311  -15.57744 55.71180 1.000 19.69584  ? 98  GLY C CA  1 
ATOM   2908 C  C   . GLY C 1 102 ? 10.76956  -14.55606 56.82455 1.000 29.15831  ? 98  GLY C C   1 
ATOM   2909 O  O   . GLY C 1 102 ? 11.55689  -14.73252 57.76199 1.000 31.02162  ? 98  GLY C O   1 
ATOM   2910 N  N   . TYR C 1 103 ? 9.96550   -13.49727 56.75686 1.000 26.39763  ? 99  TYR C N   1 
ATOM   2911 C  CA  . TYR C 1 103 ? 9.96987   -12.45068 57.76967 1.000 26.89943  ? 99  TYR C CA  1 
ATOM   2912 C  C   . TYR C 1 103 ? 8.53739   -12.05126 58.08087 1.000 29.25851  ? 99  TYR C C   1 
ATOM   2913 O  O   . TYR C 1 103 ? 7.75504   -11.77943 57.16630 1.000 23.58540  ? 99  TYR C O   1 
ATOM   2914 C  CB  . TYR C 1 103 ? 10.76789  -11.22743 57.30111 1.000 25.05123  ? 99  TYR C CB  1 
ATOM   2915 C  CG  . TYR C 1 103 ? 12.24216  -11.49348 57.09726 1.000 23.21696  ? 99  TYR C CG  1 
ATOM   2916 C  CD1 . TYR C 1 103 ? 12.72917  -11.90394 55.86308 1.000 22.11210  ? 99  TYR C CD1 1 
ATOM   2917 C  CD2 . TYR C 1 103 ? 13.14737  -11.32894 58.13701 1.000 22.74254  ? 99  TYR C CD2 1 
ATOM   2918 C  CE1 . TYR C 1 103 ? 14.07442  -12.14994 55.67183 1.000 22.96587  ? 99  TYR C CE1 1 
ATOM   2919 C  CE2 . TYR C 1 103 ? 14.49709  -11.57073 57.95467 1.000 31.80863  ? 99  TYR C CE2 1 
ATOM   2920 C  CZ  . TYR C 1 103 ? 14.95429  -11.97998 56.71975 1.000 23.17002  ? 99  TYR C CZ  1 
ATOM   2921 O  OH  . TYR C 1 103 ? 16.29439  -12.22237 56.52947 1.000 25.27099  ? 99  TYR C OH  1 
ATOM   2922 N  N   . ILE C 1 104 ? 8.19821   -12.01886 59.36437 1.000 27.03630  ? 100 ILE C N   1 
ATOM   2923 C  CA  . ILE C 1 104 ? 6.88399   -11.57026 59.80721 1.000 19.23563  ? 100 ILE C CA  1 
ATOM   2924 C  C   . ILE C 1 104 ? 6.94258   -10.06434 60.01987 1.000 28.94795  ? 100 ILE C C   1 
ATOM   2925 O  O   . ILE C 1 104 ? 7.71228   -9.57504  60.85372 1.000 21.46263  ? 100 ILE C O   1 
ATOM   2926 C  CB  . ILE C 1 104 ? 6.44696   -12.29033 61.09105 1.000 31.98077  ? 100 ILE C CB  1 
ATOM   2927 C  CG1 . ILE C 1 104 ? 6.47943   -13.80675 60.89694 1.000 26.31385  ? 100 ILE C CG1 1 
ATOM   2928 C  CG2 . ILE C 1 104 ? 5.05818   -11.83278 61.51025 1.000 24.95216  ? 100 ILE C CG2 1 
ATOM   2929 C  CD1 . ILE C 1 104 ? 6.31711   -14.57925 62.18753 1.000 24.73017  ? 100 ILE C CD1 1 
ATOM   2930 N  N   . SER C 1 105 ? 6.13698   -9.33161  59.26178 1.000 22.23732  ? 101 SER C N   1 
ATOM   2931 C  CA  . SER C 1 105 ? 6.04677   -7.88822  59.39236 1.000 25.50766  ? 101 SER C CA  1 
ATOM   2932 C  C   . SER C 1 105 ? 4.91234   -7.51185  60.34152 1.000 28.15791  ? 101 SER C C   1 
ATOM   2933 O  O   . SER C 1 105 ? 4.06290   -8.33244  60.69789 1.000 26.23951  ? 101 SER C O   1 
ATOM   2934 C  CB  . SER C 1 105 ? 5.83349   -7.24126  58.02420 1.000 32.18225  ? 101 SER C CB  1 
ATOM   2935 O  OG  . SER C 1 105 ? 4.60424   -7.65800  57.45409 1.000 24.12744  ? 101 SER C OG  1 
ATOM   2936 N  N   . ALA C 1 106 ? 4.91083   -6.24352  60.75801 1.000 18.44813  ? 102 ALA C N   1 
ATOM   2937 C  CA  . ALA C 1 106 ? 3.82401   -5.75024  61.59656 1.000 20.30039  ? 102 ALA C CA  1 
ATOM   2938 C  C   . ALA C 1 106 ? 2.48267   -5.88148  60.88721 1.000 21.58423  ? 102 ALA C C   1 
ATOM   2939 O  O   . ALA C 1 106 ? 1.46948   -6.20750  61.51572 1.000 22.61357  ? 102 ALA C O   1 
ATOM   2940 C  CB  . ALA C 1 106 ? 4.08286   -4.29838  61.99597 1.000 26.35528  ? 102 ALA C CB  1 
ATOM   2941 N  N   . ALA C 1 107 ? 2.45965   -5.64204  59.57344 1.000 25.31223  ? 103 ALA C N   1 
ATOM   2942 C  CA  . ALA C 1 107 ? 1.21765   -5.77188  58.81953 1.000 29.55807  ? 103 ALA C CA  1 
ATOM   2943 C  C   . ALA C 1 107 ? 0.73671   -7.21722  58.79187 1.000 30.27360  ? 103 ALA C C   1 
ATOM   2944 O  O   . ALA C 1 107 ? -0.46768  -7.47901  58.88881 1.000 24.73227  ? 103 ALA C O   1 
ATOM   2945 C  CB  . ALA C 1 107 ? 1.40732   -5.23861  57.39945 1.000 36.03265  ? 103 ALA C CB  1 
ATOM   2946 N  N   . GLU C 1 108 ? 1.66281   -8.17143  58.66300 1.000 25.12100  ? 104 GLU C N   1 
ATOM   2947 C  CA  . GLU C 1 108 ? 1.26860   -9.57663  58.65359 1.000 24.42163  ? 104 GLU C CA  1 
ATOM   2948 C  C   . GLU C 1 108 ? 0.77976   -10.02155 60.02559 1.000 29.59487  ? 104 GLU C C   1 
ATOM   2949 O  O   . GLU C 1 108 ? -0.21621  -10.74794 60.12917 1.000 27.93295  ? 104 GLU C O   1 
ATOM   2950 C  CB  . GLU C 1 108 ? 2.43126   -10.44916 58.18525 1.000 19.68229  ? 104 GLU C CB  1 
ATOM   2951 C  CG  . GLU C 1 108 ? 2.55844   -10.54297 56.67290 1.000 21.49891  ? 104 GLU C CG  1 
ATOM   2952 C  CD  . GLU C 1 108 ? 3.76241   -11.35440 56.23977 1.000 26.04664  ? 104 GLU C CD  1 
ATOM   2953 O  OE1 . GLU C 1 108 ? 4.82634   -11.23176 56.88367 1.000 28.88889  ? 104 GLU C OE1 1 
ATOM   2954 O  OE2 . GLU C 1 108 ? 3.64491   -12.11607 55.25677 1.000 30.07632  ? 104 GLU C OE2 1 
ATOM   2955 N  N   . LEU C 1 109 ? 1.46716   -9.59824  61.09005 1.000 28.02470  ? 105 LEU C N   1 
ATOM   2956 C  CA  . LEU C 1 109 ? 0.98796   -9.89092  62.43660 1.000 23.48385  ? 105 LEU C CA  1 
ATOM   2957 C  C   . LEU C 1 109 ? -0.36933  -9.24771  62.68216 1.000 29.23004  ? 105 LEU C C   1 
ATOM   2958 O  O   . LEU C 1 109 ? -1.25003  -9.85317  63.30505 1.000 25.24032  ? 105 LEU C O   1 
ATOM   2959 C  CB  . LEU C 1 109 ? 2.00266   -9.41287  63.47657 1.000 27.17148  ? 105 LEU C CB  1 
ATOM   2960 C  CG  . LEU C 1 109 ? 1.58369   -9.49919  64.94926 1.000 30.85298  ? 105 LEU C CG  1 
ATOM   2961 C  CD1 . LEU C 1 109 ? 1.04859   -10.88443 65.30216 1.000 30.93918  ? 105 LEU C CD1 1 
ATOM   2962 C  CD2 . LEU C 1 109 ? 2.74000   -9.11899  65.86175 1.000 34.26065  ? 105 LEU C CD2 1 
ATOM   2963 N  N   . ARG C 1 110 ? -0.56049  -8.02087  62.19550 1.000 24.45385  ? 106 ARG C N   1 
ATOM   2964 C  CA  . ARG C 1 110 ? -1.83789  -7.35118  62.40391 1.000 29.22503  ? 106 ARG C CA  1 
ATOM   2965 C  C   . ARG C 1 110 ? -2.95634  -8.03544  61.62845 1.000 23.17323  ? 106 ARG C C   1 
ATOM   2966 O  O   . ARG C 1 110 ? -4.10169  -8.07844  62.09242 1.000 30.12005  ? 106 ARG C O   1 
ATOM   2967 C  CB  . ARG C 1 110 ? -1.73754  -5.88005  62.01397 1.000 30.51167  ? 106 ARG C CB  1 
ATOM   2968 C  CG  . ARG C 1 110 ? -2.88066  -5.07150  62.57582 1.000 36.94551  ? 106 ARG C CG  1 
ATOM   2969 C  CD  . ARG C 1 110 ? -3.07676  -3.74788  61.85623 1.000 50.10521  ? 106 ARG C CD  1 
ATOM   2970 N  NE  . ARG C 1 110 ? -4.19418  -2.99117  62.41163 1.000 56.97595  ? 106 ARG C NE  1 
ATOM   2971 C  CZ  . ARG C 1 110 ? -4.34517  -2.66361  63.68921 1.000 61.92389  ? 106 ARG C CZ  1 
ATOM   2972 N  NH1 . ARG C 1 110 ? -3.39975  -2.89514  64.58590 1.000 58.26614  ? 106 ARG C NH1 1 
ATOM   2973 N  NH2 . ARG C 1 110 ? -5.47174  -2.07323  64.07618 1.000 67.79957  ? 106 ARG C NH2 1 
ATOM   2974 N  N   . HIS C 1 111 ? -2.64540  -8.57086  60.44527 1.000 23.04955  ? 107 HIS C N   1 
ATOM   2975 C  CA  . HIS C 1 111 ? -3.63899  -9.32331  59.68582 1.000 31.18916  ? 107 HIS C CA  1 
ATOM   2976 C  C   . HIS C 1 111 ? -4.14449  -10.51567 60.48597 1.000 31.70158  ? 107 HIS C C   1 
ATOM   2977 O  O   . HIS C 1 111 ? -5.35385  -10.76027 60.56467 1.000 31.12816  ? 107 HIS C O   1 
ATOM   2978 C  CB  . HIS C 1 111 ? -3.04460  -9.79002  58.35566 1.000 25.90360  ? 107 HIS C CB  1 
ATOM   2979 C  CG  . HIS C 1 111 ? -2.79594  -8.68221  57.38103 1.000 36.97640  ? 107 HIS C CG  1 
ATOM   2980 N  ND1 . HIS C 1 111 ? -2.99261  -7.35509  57.69633 1.000 36.65917  ? 107 HIS C ND1 1 
ATOM   2981 C  CD2 . HIS C 1 111 ? -2.36144  -8.70384  56.09887 1.000 33.66027  ? 107 HIS C CD2 1 
ATOM   2982 C  CE1 . HIS C 1 111 ? -2.69218  -6.60686  56.64995 1.000 38.88098  ? 107 HIS C CE1 1 
ATOM   2983 N  NE2 . HIS C 1 111 ? -2.30654  -7.40077  55.66741 1.000 39.27285  ? 107 HIS C NE2 1 
ATOM   2984 N  N   . VAL C 1 112 ? -3.22503  -11.26353 61.09900 1.000 25.93149  ? 108 VAL C N   1 
ATOM   2985 C  CA  . VAL C 1 112 ? -3.60305  -12.47438 61.82010 1.000 29.87662  ? 108 VAL C CA  1 
ATOM   2986 C  C   . VAL C 1 112 ? -4.41405  -12.13283 63.06401 1.000 30.48077  ? 108 VAL C C   1 
ATOM   2987 O  O   . VAL C 1 112 ? -5.38463  -12.82434 63.39582 1.000 37.25082  ? 108 VAL C O   1 
ATOM   2988 C  CB  . VAL C 1 112 ? -2.34909  -13.29669 62.16699 1.000 30.86325  ? 108 VAL C CB  1 
ATOM   2989 C  CG1 . VAL C 1 112 ? -2.73095  -14.54943 62.93807 1.000 31.27664  ? 108 VAL C CG1 1 
ATOM   2990 C  CG2 . VAL C 1 112 ? -1.58647  -13.65380 60.90081 1.000 33.52328  ? 108 VAL C CG2 1 
HETATM 2991 N  N   . MSE C 1 113 ? -4.03467  -11.07124 63.76941 1.000 26.90846  ? 109 MSE C N   1 
HETATM 2992 C  CA  . MSE C 1 113 ? -4.75247  -10.64754 64.96754 1.000 33.61618  ? 109 MSE C CA  1 
HETATM 2993 C  C   . MSE C 1 113 ? -6.18384  -10.24671 64.61193 1.000 32.00143  ? 109 MSE C C   1 
HETATM 2994 O  O   . MSE C 1 113 ? -7.12207  -10.53777 65.35359 1.000 35.07889  ? 109 MSE C O   1 
HETATM 2995 C  CB  . MSE C 1 113 ? -4.03780  -9.47631  65.64783 1.000 35.80239  ? 109 MSE C CB  1 
HETATM 2996 C  CG  . MSE C 1 113 ? -2.75939  -9.83250  66.40570 1.000 45.40938  ? 109 MSE C CG  1 
HETATM 2997 SE SE  . MSE C 1 113 ? -2.77615  -11.52842 67.36974 1.000 49.13511  ? 109 MSE C SE  1 
HETATM 2998 C  CE  . MSE C 1 113 ? -4.01626  -11.06745 68.80240 1.000 42.83236  ? 109 MSE C CE  1 
ATOM   2999 N  N   . THR C 1 114 ? -6.34042  -9.57588  63.46646 1.000 30.24834  ? 110 THR C N   1 
ATOM   3000 C  CA  . THR C 1 114 ? -7.66909  -9.15326  63.03037 1.000 35.53343  ? 110 THR C CA  1 
ATOM   3001 C  C   . THR C 1 114 ? -8.54610  -10.35323 62.69626 1.000 32.54114  ? 110 THR C C   1 
ATOM   3002 O  O   . THR C 1 114 ? -9.75195  -10.34829 62.97147 1.000 40.62517  ? 110 THR C O   1 
ATOM   3003 C  CB  . THR C 1 114 ? -7.55714  -8.21880  61.82394 1.000 30.87226  ? 110 THR C CB  1 
ATOM   3004 O  OG1 . THR C 1 114 ? -6.73114  -7.09670  62.16058 1.000 27.04985  ? 110 THR C OG1 1 
ATOM   3005 C  CG2 . THR C 1 114 ? -8.93340  -7.71888  61.39870 1.000 30.82767  ? 110 THR C CG2 1 
ATOM   3006 N  N   . ASN C 1 115 ? -7.95788  -11.39559 62.10674 1.000 30.84961  ? 111 ASN C N   1 
ATOM   3007 C  CA  . ASN C 1 115 ? -8.71579  -12.60913 61.83332 1.000 39.45768  ? 111 ASN C CA  1 
ATOM   3008 C  C   . ASN C 1 115 ? -9.09979  -13.34102 63.11229 1.000 43.28224  ? 111 ASN C C   1 
ATOM   3009 O  O   . ASN C 1 115 ? -10.04330 -14.13933 63.09721 1.000 36.67897  ? 111 ASN C O   1 
ATOM   3010 C  CB  . ASN C 1 115 ? -7.91951  -13.53401 60.91374 1.000 33.48005  ? 111 ASN C CB  1 
ATOM   3011 C  CG  . ASN C 1 115 ? -8.80834  -14.31874 59.97257 1.000 34.39348  ? 111 ASN C CG  1 
ATOM   3012 O  OD1 . ASN C 1 115 ? -9.81630  -13.80792 59.48281 1.000 32.56576  ? 111 ASN C OD1 1 
ATOM   3013 N  ND2 . ASN C 1 115 ? -8.44104  -15.56756 59.71450 1.000 30.56720  ? 111 ASN C ND2 1 
ATOM   3014 N  N   . LEU C 1 116 ? -8.39305  -13.08925 64.21197 1.000 35.26769  ? 112 LEU C N   1 
ATOM   3015 C  CA  . LEU C 1 116 ? -8.77812  -13.59717 65.52045 1.000 37.47971  ? 112 LEU C CA  1 
ATOM   3016 C  C   . LEU C 1 116 ? -9.74662  -12.67129 66.24461 1.000 40.74948  ? 112 LEU C C   1 
ATOM   3017 O  O   . LEU C 1 116 ? -10.10346 -12.94717 67.39468 1.000 41.50748  ? 112 LEU C O   1 
ATOM   3018 C  CB  . LEU C 1 116 ? -7.53429  -13.82545 66.38623 1.000 30.91453  ? 112 LEU C CB  1 
ATOM   3019 C  CG  . LEU C 1 116 ? -6.61369  -14.96659 65.94991 1.000 36.59187  ? 112 LEU C CG  1 
ATOM   3020 C  CD1 . LEU C 1 116 ? -5.19745  -14.73232 66.45010 1.000 37.09170  ? 112 LEU C CD1 1 
ATOM   3021 C  CD2 . LEU C 1 116 ? -7.14696  -16.30517 66.44200 1.000 20.38414  ? 112 LEU C CD2 1 
ATOM   3022 N  N   . GLY C 1 117 ? -10.17427 -11.58503 65.60378 1.000 38.08272  ? 113 GLY C N   1 
ATOM   3023 C  CA  . GLY C 1 117 ? -11.13822 -10.68333 66.20083 1.000 34.86289  ? 113 GLY C CA  1 
ATOM   3024 C  C   . GLY C 1 117 ? -10.58069 -9.72440  67.22557 1.000 42.58893  ? 113 GLY C C   1 
ATOM   3025 O  O   . GLY C 1 117 ? -11.34942 -9.16817  68.01556 1.000 48.11236  ? 113 GLY C O   1 
ATOM   3026 N  N   . GLU C 1 118 ? -9.26889  -9.50235  67.23556 1.000 44.66946  ? 114 GLU C N   1 
ATOM   3027 C  CA  . GLU C 1 118 ? -8.63969  -8.65291  68.23675 1.000 44.56952  ? 114 GLU C CA  1 
ATOM   3028 C  C   . GLU C 1 118 ? -8.58530  -7.20449  67.76806 1.000 46.84483  ? 114 GLU C C   1 
ATOM   3029 O  O   . GLU C 1 118 ? -8.31538  -6.92408  66.59656 1.000 45.06120  ? 114 GLU C O   1 
ATOM   3030 C  CB  . GLU C 1 118 ? -7.22893  -9.14953  68.55618 1.000 41.88036  ? 114 GLU C CB  1 
ATOM   3031 C  CG  . GLU C 1 118 ? -6.96970  -9.34430  70.04128 1.000 49.91338  ? 114 GLU C CG  1 
ATOM   3032 C  CD  . GLU C 1 118 ? -7.88242  -10.38597 70.65820 1.000 50.80480  ? 114 GLU C CD  1 
ATOM   3033 O  OE1 . GLU C 1 118 ? -8.16087  -11.40435 69.99027 1.000 40.08389  ? 114 GLU C OE1 1 
ATOM   3034 O  OE2 . GLU C 1 118 ? -8.32133  -10.18763 71.81066 1.000 54.45341  ? 114 GLU C OE2 1 
ATOM   3035 N  N   . LYS C 1 119 ? -8.84300  -6.28723  68.69918 1.000 53.61156  ? 115 LYS C N   1 
ATOM   3036 C  CA  . LYS C 1 119 ? -8.80360  -4.84846  68.44348 1.000 58.61881  ? 115 LYS C CA  1 
ATOM   3037 C  C   . LYS C 1 119 ? -7.45484  -4.32909  68.92682 1.000 62.73875  ? 115 LYS C C   1 
ATOM   3038 O  O   . LYS C 1 119 ? -7.27685  -4.04619  70.11407 1.000 69.02869  ? 115 LYS C O   1 
ATOM   3039 C  CB  . LYS C 1 119 ? -9.95423  -4.13959  69.15029 1.000 60.47254  ? 115 LYS C CB  1 
ATOM   3040 C  CG  . LYS C 1 119 ? -11.01282 -3.56931  68.22656 1.000 59.43320  ? 115 LYS C CG  1 
ATOM   3041 C  CD  . LYS C 1 119 ? -11.88125 -4.67106  67.64585 1.000 65.25059  ? 115 LYS C CD  1 
ATOM   3042 C  CE  . LYS C 1 119 ? -13.10503 -4.09552  66.95658 1.000 59.11498  ? 115 LYS C CE  1 
ATOM   3043 N  NZ  . LYS C 1 119 ? -13.78545 -3.07915  67.80621 1.000 52.78058  ? 115 LYS C NZ  1 
ATOM   3044 N  N   . LEU C 1 120 ? -6.50467  -4.20150  68.00594 1.000 54.62171  ? 116 LEU C N   1 
ATOM   3045 C  CA  . LEU C 1 120 ? -5.15114  -3.78123  68.33385 1.000 64.37965  ? 116 LEU C CA  1 
ATOM   3046 C  C   . LEU C 1 120 ? -4.81995  -2.48299  67.61390 1.000 64.50514  ? 116 LEU C C   1 
ATOM   3047 O  O   . LEU C 1 120 ? -5.23860  -2.27061  66.47206 1.000 65.81291  ? 116 LEU C O   1 
ATOM   3048 C  CB  . LEU C 1 120 ? -4.13229  -4.86012  67.95255 1.000 61.86164  ? 116 LEU C CB  1 
ATOM   3049 C  CG  . LEU C 1 120 ? -4.04185  -6.05513  68.90275 1.000 55.89386  ? 116 LEU C CG  1 
ATOM   3050 C  CD1 . LEU C 1 120 ? -2.82472  -6.90615  68.58001 1.000 49.09550  ? 116 LEU C CD1 1 
ATOM   3051 C  CD2 . LEU C 1 120 ? -4.00590  -5.58518  70.34845 1.000 48.25563  ? 116 LEU C CD2 1 
ATOM   3052 N  N   . THR C 1 121 ? -4.07916  -1.61204  68.29137 1.000 63.28134  ? 117 THR C N   1 
ATOM   3053 C  CA  . THR C 1 121 ? -3.54949  -0.42383  67.64626 1.000 59.82545  ? 117 THR C CA  1 
ATOM   3054 C  C   . THR C 1 121 ? -2.26285  -0.76646  66.90394 1.000 53.55819  ? 117 THR C C   1 
ATOM   3055 O  O   . THR C 1 121 ? -1.65536  -1.81969  67.11504 1.000 57.18162  ? 117 THR C O   1 
ATOM   3056 C  CB  . THR C 1 121 ? -3.28551  0.68303   68.66881 1.000 56.35441  ? 117 THR C CB  1 
ATOM   3057 O  OG1 . THR C 1 121 ? -1.97460  0.52037   69.22552 1.000 57.64550  ? 117 THR C OG1 1 
ATOM   3058 C  CG2 . THR C 1 121 ? -4.31956  0.64117   69.78530 1.000 54.61968  ? 117 THR C CG2 1 
ATOM   3059 N  N   . ASP C 1 122 ? -1.85323  0.13916   66.01378 1.000 56.90315  ? 118 ASP C N   1 
ATOM   3060 C  CA  . ASP C 1 122 ? -0.59780  -0.06273  65.29907 1.000 58.51568  ? 118 ASP C CA  1 
ATOM   3061 C  C   . ASP C 1 122 ? 0.57831   -0.11496  66.26579 1.000 55.43852  ? 118 ASP C C   1 
ATOM   3062 O  O   . ASP C 1 122 ? 1.51568   -0.89785  66.07310 1.000 55.73377  ? 118 ASP C O   1 
ATOM   3063 C  CB  . ASP C 1 122 ? -0.39909  1.03924   64.25844 1.000 61.65880  ? 118 ASP C CB  1 
ATOM   3064 C  CG  . ASP C 1 122 ? -1.39102  0.94457   63.11481 1.000 72.83416  ? 118 ASP C CG  1 
ATOM   3065 O  OD1 . ASP C 1 122 ? -1.10324  0.22371   62.13626 1.000 69.40314  ? 118 ASP C OD1 1 
ATOM   3066 O  OD2 . ASP C 1 122 ? -2.45677  1.59138   63.19319 1.000 68.01762  ? 118 ASP C OD2 1 
ATOM   3067 N  N   . GLU C 1 123 ? 0.53535   0.69645   67.32576 1.000 53.58322  ? 119 GLU C N   1 
ATOM   3068 C  CA  . GLU C 1 123 ? 1.61127   0.68537   68.31098 1.000 49.10629  ? 119 GLU C CA  1 
ATOM   3069 C  C   . GLU C 1 123 ? 1.60354   -0.59129  69.14326 1.000 50.66709  ? 119 GLU C C   1 
ATOM   3070 O  O   . GLU C 1 123 ? 2.67062   -1.07492  69.53951 1.000 52.81807  ? 119 GLU C O   1 
ATOM   3071 C  CB  . GLU C 1 123 ? 1.50582   1.91352   69.21443 1.000 55.59561  ? 119 GLU C CB  1 
ATOM   3072 C  CG  . GLU C 1 123 ? 1.40052   3.22792   68.45623 1.000 61.13869  ? 119 GLU C CG  1 
ATOM   3073 C  CD  . GLU C 1 123 ? -0.02256  3.74714   68.37943 1.000 62.84385  ? 119 GLU C CD  1 
ATOM   3074 O  OE1 . GLU C 1 123 ? -0.87264  3.07365   67.75878 1.000 56.29817  ? 119 GLU C OE1 1 
ATOM   3075 O  OE2 . GLU C 1 123 ? -0.29110  4.83047   68.93951 1.000 72.78389  ? 119 GLU C OE2 1 
ATOM   3076 N  N   . GLU C 1 124 ? 0.42090   -1.14768  69.42329 1.000 45.69559  ? 120 GLU C N   1 
ATOM   3077 C  CA  . GLU C 1 124 ? 0.36095   -2.42022  70.13487 1.000 45.52133  ? 120 GLU C CA  1 
ATOM   3078 C  C   . GLU C 1 124 ? 0.94750   -3.55188  69.30267 1.000 43.14065  ? 120 GLU C C   1 
ATOM   3079 O  O   . GLU C 1 124 ? 1.50501   -4.50494  69.85921 1.000 41.48604  ? 120 GLU C O   1 
ATOM   3080 C  CB  . GLU C 1 124 ? -1.08061  -2.74781  70.52374 1.000 54.67127  ? 120 GLU C CB  1 
ATOM   3081 C  CG  . GLU C 1 124 ? -1.61346  -1.94419  71.69706 1.000 51.02373  ? 120 GLU C CG  1 
ATOM   3082 C  CD  . GLU C 1 124 ? -3.06808  -2.25097  72.00034 1.000 57.48818  ? 120 GLU C CD  1 
ATOM   3083 O  OE1 . GLU C 1 124 ? -3.87901  -2.30932  71.05190 1.000 60.62934  ? 120 GLU C OE1 1 
ATOM   3084 O  OE2 . GLU C 1 124 ? -3.40180  -2.43235  73.19012 1.000 61.36412  ? 120 GLU C OE2 1 
ATOM   3085 N  N   . VAL C 1 125 ? 0.83133   -3.46717  67.97600 1.000 42.77319  ? 121 VAL C N   1 
ATOM   3086 C  CA  . VAL C 1 125 ? 1.42717   -4.48307  67.11541 1.000 44.89125  ? 121 VAL C CA  1 
ATOM   3087 C  C   . VAL C 1 125 ? 2.94017   -4.30777  67.05541 1.000 48.03823  ? 121 VAL C C   1 
ATOM   3088 O  O   . VAL C 1 125 ? 3.69250   -5.28887  67.09112 1.000 40.88392  ? 121 VAL C O   1 
ATOM   3089 C  CB  . VAL C 1 125 ? 0.78894   -4.43806  65.71476 1.000 46.89926  ? 121 VAL C CB  1 
ATOM   3090 C  CG1 . VAL C 1 125 ? 1.52542   -5.36780  64.76024 1.000 43.78236  ? 121 VAL C CG1 1 
ATOM   3091 C  CG2 . VAL C 1 125 ? -0.68492  -4.80599  65.79487 1.000 42.23783  ? 121 VAL C CG2 1 
ATOM   3092 N  N   . ASP C 1 126 ? 3.41175   -3.05881  66.97115 1.000 44.21409  ? 122 ASP C N   1 
ATOM   3093 C  CA  . ASP C 1 126 ? 4.85035   -2.80891  66.99762 1.000 42.27771  ? 122 ASP C CA  1 
ATOM   3094 C  C   . ASP C 1 126 ? 5.47269   -3.31084  68.29445 1.000 37.52550  ? 122 ASP C C   1 
ATOM   3095 O  O   . ASP C 1 126 ? 6.59867   -3.82246  68.29435 1.000 41.60791  ? 122 ASP C O   1 
ATOM   3096 C  CB  . ASP C 1 126 ? 5.13770   -1.31755  66.81524 1.000 44.56451  ? 122 ASP C CB  1 
ATOM   3097 C  CG  . ASP C 1 126 ? 4.82559   -0.82630  65.41536 1.000 57.29385  ? 122 ASP C CG  1 
ATOM   3098 O  OD1 . ASP C 1 126 ? 5.45244   -1.32412  64.45743 1.000 51.79571  ? 122 ASP C OD1 1 
ATOM   3099 O  OD2 . ASP C 1 126 ? 3.97648   0.07860   65.27380 1.000 56.38248  ? 122 ASP C OD2 1 
ATOM   3100 N  N   . GLU C 1 127 ? 4.75305   -3.17246  69.41120 1.000 40.34787  ? 123 GLU C N   1 
ATOM   3101 C  CA  . GLU C 1 127 ? 5.26335   -3.66039  70.68809 1.000 39.29898  ? 123 GLU C CA  1 
ATOM   3102 C  C   . GLU C 1 127 ? 5.43031   -5.17391  70.67117 1.000 41.18993  ? 123 GLU C C   1 
ATOM   3103 O  O   . GLU C 1 127 ? 6.41003   -5.70411  71.20804 1.000 42.23625  ? 123 GLU C O   1 
ATOM   3104 C  CB  . GLU C 1 127 ? 4.32991   -3.23318  71.82033 1.000 42.14566  ? 123 GLU C CB  1 
ATOM   3105 C  CG  . GLU C 1 127 ? 4.86583   -3.51488  73.21443 1.000 46.54732  ? 123 GLU C CG  1 
ATOM   3106 C  CD  . GLU C 1 127 ? 3.93251   -3.02408  74.30374 1.000 57.16618  ? 123 GLU C CD  1 
ATOM   3107 O  OE1 . GLU C 1 127 ? 3.10019   -2.13712  74.01853 1.000 67.03039  ? 123 GLU C OE1 1 
ATOM   3108 O  OE2 . GLU C 1 127 ? 4.02970   -3.52473  75.44430 1.000 57.81938  ? 123 GLU C OE2 1 
HETATM 3109 N  N   . MSE C 1 128 ? 4.48683   -5.88353  70.06031 1.000 34.94773  ? 124 MSE C N   1 
HETATM 3110 C  CA  . MSE C 1 128 ? 4.57796   -7.33190  69.92920 1.000 40.11065  ? 124 MSE C CA  1 
HETATM 3111 C  C   . MSE C 1 128 ? 5.76539   -7.71130  69.05190 1.000 30.51708  ? 124 MSE C C   1 
HETATM 3112 O  O   . MSE C 1 128 ? 6.47094   -8.68093  69.32875 1.000 23.12160  ? 124 MSE C O   1 
HETATM 3113 C  CB  . MSE C 1 128 ? 3.28501   -7.90349  69.34390 1.000 29.91041  ? 124 MSE C CB  1 
HETATM 3114 C  CG  . MSE C 1 128 ? 2.07236   -7.77286  70.25112 1.000 47.38456  ? 124 MSE C CG  1 
HETATM 3115 SE SE  . MSE C 1 128 ? 0.46516   -8.54812  69.45592 1.000 55.84301  ? 124 MSE C SE  1 
HETATM 3116 C  CE  . MSE C 1 128 ? 0.56506   -10.32694 70.25086 1.000 50.19621  ? 124 MSE C CE  1 
ATOM   3117 N  N   . ILE C 1 129 ? 5.97731   -6.93337  67.98809 1.000 30.28413  ? 125 ILE C N   1 
ATOM   3118 C  CA  . ILE C 1 129 ? 7.10615   -7.18264  67.09509 1.000 34.31253  ? 125 ILE C CA  1 
ATOM   3119 C  C   . ILE C 1 129 ? 8.42126   -6.95993  67.83194 1.000 26.40830  ? 125 ILE C C   1 
ATOM   3120 O  O   . ILE C 1 129 ? 9.35349   -7.76750  67.73558 1.000 26.29493  ? 125 ILE C O   1 
ATOM   3121 C  CB  . ILE C 1 129 ? 7.00599   -6.29573  65.84032 1.000 29.28531  ? 125 ILE C CB  1 
ATOM   3122 C  CG1 . ILE C 1 129 ? 5.73071   -6.61373  65.05297 1.000 23.35457  ? 125 ILE C CG1 1 
ATOM   3123 C  CG2 . ILE C 1 129 ? 8.24260   -6.46569  64.96637 1.000 27.59440  ? 125 ILE C CG2 1 
ATOM   3124 C  CD1 . ILE C 1 129 ? 5.85049   -7.81384  64.13793 1.000 27.98067  ? 125 ILE C CD1 1 
ATOM   3125 N  N   . ARG C 1 130 ? 8.51058   -5.86092  68.58741 1.000 31.26862  ? 126 ARG C N   1 
ATOM   3126 C  CA  . ARG C 1 130 ? 9.74049   -5.55114  69.31024 1.000 41.18291  ? 126 ARG C CA  1 
ATOM   3127 C  C   . ARG C 1 130 ? 10.08188  -6.62768  70.33147 1.000 33.43198  ? 126 ARG C C   1 
ATOM   3128 O  O   . ARG C 1 130 ? 11.26335  -6.90044  70.57277 1.000 32.69323  ? 126 ARG C O   1 
ATOM   3129 C  CB  . ARG C 1 130 ? 9.61750   -4.19064  69.99784 1.000 45.83952  ? 126 ARG C CB  1 
ATOM   3130 C  CG  . ARG C 1 130 ? 9.72007   -3.00560  69.05496 1.000 42.29439  ? 126 ARG C CG  1 
ATOM   3131 C  CD  . ARG C 1 130 ? 9.66755   -1.68936  69.81369 1.000 51.57022  ? 126 ARG C CD  1 
ATOM   3132 N  NE  . ARG C 1 130 ? 8.46277   -0.92958  69.50282 1.000 60.52601  ? 126 ARG C NE  1 
ATOM   3133 C  CZ  . ARG C 1 130 ? 7.44521   -0.76163  70.33633 1.000 56.01135  ? 126 ARG C CZ  1 
ATOM   3134 N  NH1 . ARG C 1 130 ? 7.45816   -1.27462  71.55586 1.000 57.23006  ? 126 ARG C NH1 1 
ATOM   3135 N  NH2 . ARG C 1 130 ? 6.38918   -0.05862  69.93716 1.000 55.87925  ? 126 ARG C NH2 1 
ATOM   3136 N  N   . GLU C 1 131 ? 9.06808   -7.25193  70.93553 1.000 31.32904  ? 127 GLU C N   1 
ATOM   3137 C  CA  . GLU C 1 131 ? 9.32629   -8.30663  71.91035 1.000 35.38569  ? 127 GLU C CA  1 
ATOM   3138 C  C   . GLU C 1 131 ? 9.93365   -9.53869  71.25058 1.000 29.56085  ? 127 GLU C C   1 
ATOM   3139 O  O   . GLU C 1 131 ? 10.78624  -10.20882 71.84322 1.000 34.14551  ? 127 GLU C O   1 
ATOM   3140 C  CB  . GLU C 1 131 ? 8.03548   -8.67178  72.64270 1.000 43.60241  ? 127 GLU C CB  1 
ATOM   3141 N  N   . ALA C 1 132 ? 9.50901   -9.85916  70.02848 1.000 28.57220  ? 128 ALA C N   1 
ATOM   3142 C  CA  . ALA C 1 132 ? 10.04894  -11.03475 69.35619 1.000 30.95942  ? 128 ALA C CA  1 
ATOM   3143 C  C   . ALA C 1 132 ? 11.33127  -10.72079 68.59878 1.000 27.40679  ? 128 ALA C C   1 
ATOM   3144 O  O   . ALA C 1 132 ? 12.16724  -11.61116 68.40661 1.000 25.15267  ? 128 ALA C O   1 
ATOM   3145 C  CB  . ALA C 1 132 ? 9.00806   -11.62373 68.40365 1.000 30.65834  ? 128 ALA C CB  1 
ATOM   3146 N  N   . ASP C 1 133 ? 11.50762  -9.47168  68.17916 1.000 29.48281  ? 129 ASP C N   1 
ATOM   3147 C  CA  . ASP C 1 133 ? 12.66730  -9.09538  67.38343 1.000 24.97331  ? 129 ASP C CA  1 
ATOM   3148 C  C   . ASP C 1 133 ? 13.94071  -9.17365  68.21755 1.000 25.62565  ? 129 ASP C C   1 
ATOM   3149 O  O   . ASP C 1 133 ? 13.98818  -8.67957  69.34807 1.000 27.90473  ? 129 ASP C O   1 
ATOM   3150 C  CB  . ASP C 1 133 ? 12.47924  -7.68515  66.82883 1.000 27.17962  ? 129 ASP C CB  1 
ATOM   3151 C  CG  . ASP C 1 133 ? 13.44810  -7.36344  65.71469 1.000 23.98089  ? 129 ASP C CG  1 
ATOM   3152 O  OD1 . ASP C 1 133 ? 14.18485  -8.27333  65.28285 1.000 24.51361  ? 129 ASP C OD1 1 
ATOM   3153 O  OD2 . ASP C 1 133 ? 13.46262  -6.20048  65.26281 1.000 25.01896  ? 129 ASP C OD2 1 
ATOM   3154 N  N   . ILE C 1 134 ? 14.97283  -9.79760  67.65695 1.000 19.81829  ? 130 ILE C N   1 
ATOM   3155 C  CA  . ILE C 1 134 ? 16.27029  -9.93015  68.30721 1.000 27.65649  ? 130 ILE C CA  1 
ATOM   3156 C  C   . ILE C 1 134 ? 17.33043  -9.08632  67.60825 1.000 28.01110  ? 130 ILE C C   1 
ATOM   3157 O  O   . ILE C 1 134 ? 18.04407  -8.31459  68.24996 1.000 22.13852  ? 130 ILE C O   1 
ATOM   3158 C  CB  . ILE C 1 134 ? 16.70495  -11.41099 68.38173 1.000 29.97055  ? 130 ILE C CB  1 
ATOM   3159 C  CG1 . ILE C 1 134 ? 15.76483  -12.19686 69.29436 1.000 36.60134  ? 130 ILE C CG1 1 
ATOM   3160 C  CG2 . ILE C 1 134 ? 18.13603  -11.51856 68.88430 1.000 31.84964  ? 130 ILE C CG2 1 
ATOM   3161 C  CD1 . ILE C 1 134 ? 16.00928  -13.68683 69.27565 1.000 31.53677  ? 130 ILE C CD1 1 
ATOM   3162 N  N   . ASP C 1 135 ? 17.44678  -9.22086  66.28567 1.000 26.25663  ? 131 ASP C N   1 
ATOM   3163 C  CA  . ASP C 1 135 ? 18.47388  -8.48910  65.55551 1.000 22.36942  ? 131 ASP C CA  1 
ATOM   3164 C  C   . ASP C 1 135 ? 18.13188  -7.01635  65.36784 1.000 22.63784  ? 131 ASP C C   1 
ATOM   3165 O  O   . ASP C 1 135 ? 19.03406  -6.21605  65.09823 1.000 27.34232  ? 131 ASP C O   1 
ATOM   3166 C  CB  . ASP C 1 135 ? 18.72739  -9.14491  64.19500 1.000 25.65940  ? 131 ASP C CB  1 
ATOM   3167 C  CG  . ASP C 1 135 ? 17.44596  -9.44628  63.43848 1.000 16.84505  ? 131 ASP C CG  1 
ATOM   3168 O  OD1 . ASP C 1 135 ? 16.49758  -8.63762  63.51305 1.000 15.63815  ? 131 ASP C OD1 1 
ATOM   3169 O  OD2 . ASP C 1 135 ? 17.39030  -10.49365 62.76292 1.000 25.46827  ? 131 ASP C OD2 1 
ATOM   3170 N  N   . GLY C 1 136 ? 16.86262  -6.64211  65.49764 1.000 23.35133  ? 132 GLY C N   1 
ATOM   3171 C  CA  . GLY C 1 136 ? 16.47680  -5.24770  65.42347 1.000 24.64000  ? 132 GLY C CA  1 
ATOM   3172 C  C   . GLY C 1 136 ? 16.08933  -4.74198  64.05410 1.000 27.22735  ? 132 GLY C C   1 
ATOM   3173 O  O   . GLY C 1 136 ? 16.09120  -3.52440  63.83920 1.000 24.75187  ? 132 GLY C O   1 
ATOM   3174 N  N   . ASP C 1 137 ? 15.75366  -5.62679  63.12030 1.000 16.08424  ? 133 ASP C N   1 
ATOM   3175 C  CA  . ASP C 1 137 ? 15.37553  -5.21294  61.77566 1.000 21.26780  ? 133 ASP C CA  1 
ATOM   3176 C  C   . ASP C 1 137 ? 13.90112  -4.84411  61.65375 1.000 22.88736  ? 133 ASP C C   1 
ATOM   3177 O  O   . ASP C 1 137 ? 13.44179  -4.54640  60.54594 1.000 21.99148  ? 133 ASP C O   1 
ATOM   3178 C  CB  . ASP C 1 137 ? 15.72192  -6.31501  60.76685 1.000 22.80482  ? 133 ASP C CB  1 
ATOM   3179 C  CG  . ASP C 1 137 ? 14.90525  -7.57883  60.96982 1.000 17.58633  ? 133 ASP C CG  1 
ATOM   3180 O  OD1 . ASP C 1 137 ? 14.25445  -7.71392  62.02649 1.000 19.43960  ? 133 ASP C OD1 1 
ATOM   3181 O  OD2 . ASP C 1 137 ? 14.91615  -8.44132  60.06656 1.000 20.94727  ? 133 ASP C OD2 1 
ATOM   3182 N  N   . GLY C 1 138 ? 13.15330  -4.85172  62.75554 1.000 27.24316  ? 134 GLY C N   1 
ATOM   3183 C  CA  . GLY C 1 138 ? 11.73877  -4.54788  62.72075 1.000 20.55676  ? 134 GLY C CA  1 
ATOM   3184 C  C   . GLY C 1 138 ? 10.84806  -5.68679  62.27696 1.000 27.85837  ? 134 GLY C C   1 
ATOM   3185 O  O   . GLY C 1 138 ? 9.63376   -5.48482  62.14385 1.000 20.69348  ? 134 GLY C O   1 
ATOM   3186 N  N   . GLN C 1 139 ? 11.40598  -6.87213  62.04274 1.000 20.25770  ? 135 GLN C N   1 
ATOM   3187 C  CA  . GLN C 1 139 ? 10.65447  -8.03207  61.59174 1.000 22.69144  ? 135 GLN C CA  1 
ATOM   3188 C  C   . GLN C 1 139 ? 11.05061  -9.24162  62.42730 1.000 30.45229  ? 135 GLN C C   1 
ATOM   3189 O  O   . GLN C 1 139 ? 12.00046  -9.19940  63.21372 1.000 21.42588  ? 135 GLN C O   1 
ATOM   3190 C  CB  . GLN C 1 139 ? 10.89490  -8.30577  60.10176 1.000 21.25458  ? 135 GLN C CB  1 
ATOM   3191 C  CG  . GLN C 1 139 ? 10.48244  -7.16358  59.19196 1.000 28.75316  ? 135 GLN C CG  1 
ATOM   3192 C  CD  . GLN C 1 139 ? 10.37474  -7.58435  57.74287 1.000 32.06883  ? 135 GLN C CD  1 
ATOM   3193 O  OE1 . GLN C 1 139 ? 11.37839  -7.88777  57.09946 1.000 20.35960  ? 135 GLN C OE1 1 
ATOM   3194 N  NE2 . GLN C 1 139 ? 9.15370   -7.60274  57.21901 1.000 25.87125  ? 135 GLN C NE2 1 
ATOM   3195 N  N   . VAL C 1 140 ? 10.31079  -10.33208 62.24578 1.000 19.79579  ? 136 VAL C N   1 
ATOM   3196 C  CA  . VAL C 1 140 ? 10.50944  -11.56306 63.00359 1.000 19.86818  ? 136 VAL C CA  1 
ATOM   3197 C  C   . VAL C 1 140 ? 10.78303  -12.68440 62.01077 1.000 20.27575  ? 136 VAL C C   1 
ATOM   3198 O  O   . VAL C 1 140 ? 9.89070   -13.07724 61.24777 1.000 27.75377  ? 136 VAL C O   1 
ATOM   3199 C  CB  . VAL C 1 140 ? 9.29923   -11.89587 63.88799 1.000 20.29153  ? 136 VAL C CB  1 
ATOM   3200 C  CG1 . VAL C 1 140 ? 9.57494   -13.13570 64.72730 1.000 20.15113  ? 136 VAL C CG1 1 
ATOM   3201 C  CG2 . VAL C 1 140 ? 8.94127   -10.70962 64.77336 1.000 23.02081  ? 136 VAL C CG2 1 
ATOM   3202 N  N   . ASN C 1 141 ? 12.01053  -13.20222 62.01724 1.000 23.48036  ? 137 ASN C N   1 
ATOM   3203 C  CA  . ASN C 1 141 ? 12.35065  -14.35813 61.20447 1.000 22.67248  ? 137 ASN C CA  1 
ATOM   3204 C  C   . ASN C 1 141 ? 12.00460  -15.63843 61.96463 1.000 22.86641  ? 137 ASN C C   1 
ATOM   3205 O  O   . ASN C 1 141 ? 11.46889  -15.60331 63.07544 1.000 18.00868  ? 137 ASN C O   1 
ATOM   3206 C  CB  . ASN C 1 141 ? 13.82351  -14.31027 60.78695 1.000 21.98277  ? 137 ASN C CB  1 
ATOM   3207 C  CG  . ASN C 1 141 ? 14.78843  -14.37368 61.96909 1.000 33.62312  ? 137 ASN C CG  1 
ATOM   3208 O  OD1 . ASN C 1 141 ? 14.42191  -14.75173 63.08122 1.000 29.13227  ? 137 ASN C OD1 1 
ATOM   3209 N  ND2 . ASN C 1 141 ? 16.03974  -14.00328 61.71998 1.000 29.48163  ? 137 ASN C ND2 1 
ATOM   3210 N  N   . TYR C 1 142 ? 12.32436  -16.78984 61.36869 1.000 24.64472  ? 138 TYR C N   1 
ATOM   3211 C  CA  . TYR C 1 142 ? 11.93593  -18.05560 61.98416 1.000 30.68890  ? 138 TYR C CA  1 
ATOM   3212 C  C   . TYR C 1 142 ? 12.66418  -18.28189 63.30426 1.000 20.90796  ? 138 TYR C C   1 
ATOM   3213 O  O   . TYR C 1 142 ? 12.04709  -18.67450 64.30080 1.000 29.04153  ? 138 TYR C O   1 
ATOM   3214 C  CB  . TYR C 1 142 ? 12.18951  -19.22614 61.03506 1.000 19.56227  ? 138 TYR C CB  1 
ATOM   3215 C  CG  . TYR C 1 142 ? 11.86461  -20.54760 61.69013 1.000 29.90678  ? 138 TYR C CG  1 
ATOM   3216 C  CD1 . TYR C 1 142 ? 10.56876  -20.83707 62.09610 1.000 28.33530  ? 138 TYR C CD1 1 
ATOM   3217 C  CD2 . TYR C 1 142 ? 12.85449  -21.48765 61.93875 1.000 27.66332  ? 138 TYR C CD2 1 
ATOM   3218 C  CE1 . TYR C 1 142 ? 10.26307  -22.03199 62.71149 1.000 36.36417  ? 138 TYR C CE1 1 
ATOM   3219 C  CE2 . TYR C 1 142 ? 12.55804  -22.68809 62.55406 1.000 30.42311  ? 138 TYR C CE2 1 
ATOM   3220 C  CZ  . TYR C 1 142 ? 11.26003  -22.95410 62.93897 1.000 38.07521  ? 138 TYR C CZ  1 
ATOM   3221 O  OH  . TYR C 1 142 ? 10.95818  -24.14579 63.55730 1.000 50.13621  ? 138 TYR C OH  1 
ATOM   3222 N  N   . GLU C 1 143 ? 13.97947  -18.04481 63.32962 1.000 29.86779  ? 139 GLU C N   1 
ATOM   3223 C  CA  . GLU C 1 143 ? 14.75223  -18.28478 64.54651 1.000 33.48723  ? 139 GLU C CA  1 
ATOM   3224 C  C   . GLU C 1 143 ? 14.20203  -17.48458 65.72102 1.000 33.83584  ? 139 GLU C C   1 
ATOM   3225 O  O   . GLU C 1 143 ? 14.06764  -18.01220 66.83123 1.000 41.21590  ? 139 GLU C O   1 
ATOM   3226 C  CB  . GLU C 1 143 ? 16.22568  -17.95122 64.31048 1.000 33.46241  ? 139 GLU C CB  1 
ATOM   3227 C  CG  . GLU C 1 143 ? 17.05720  -17.85345 65.58462 1.000 32.80652  ? 139 GLU C CG  1 
ATOM   3228 C  CD  . GLU C 1 143 ? 17.26931  -19.19792 66.25473 1.000 43.66288  ? 139 GLU C CD  1 
ATOM   3229 O  OE1 . GLU C 1 143 ? 17.61580  -20.16980 65.55170 1.000 38.16463  ? 139 GLU C OE1 1 
ATOM   3230 O  OE2 . GLU C 1 143 ? 17.09070  -19.28362 67.48790 1.000 40.09118  ? 139 GLU C OE2 1 
ATOM   3231 N  N   . GLU C 1 144 ? 13.86939  -16.21116 65.49440 1.000 25.54108  ? 140 GLU C N   1 
ATOM   3232 C  CA  . GLU C 1 144 ? 13.25432  -15.41108 66.54904 1.000 30.78548  ? 140 GLU C CA  1 
ATOM   3233 C  C   . GLU C 1 144 ? 11.86970  -15.93855 66.90565 1.000 29.92493  ? 140 GLU C C   1 
ATOM   3234 O  O   . GLU C 1 144 ? 11.45437  -15.86901 68.06851 1.000 28.29516  ? 140 GLU C O   1 
ATOM   3235 C  CB  . GLU C 1 144 ? 13.17785  -13.94487 66.12092 1.000 27.92340  ? 140 GLU C CB  1 
ATOM   3236 C  CG  . GLU C 1 144 ? 14.53039  -13.29146 65.87790 1.000 30.64238  ? 140 GLU C CG  1 
ATOM   3237 C  CD  . GLU C 1 144 ? 14.42350  -12.00370 65.08217 1.000 29.40054  ? 140 GLU C CD  1 
ATOM   3238 O  OE1 . GLU C 1 144 ? 13.54093  -11.92108 64.20264 1.000 26.89674  ? 140 GLU C OE1 1 
ATOM   3239 O  OE2 . GLU C 1 144 ? 15.22482  -11.07703 65.32961 1.000 19.15985  ? 140 GLU C OE2 1 
ATOM   3240 N  N   . PHE C 1 145 ? 11.14178  -16.46919 65.91868 1.000 30.60325  ? 141 PHE C N   1 
ATOM   3241 C  CA  . PHE C 1 145 ? 9.81720   -17.02125 66.18760 1.000 31.31379  ? 141 PHE C CA  1 
ATOM   3242 C  C   . PHE C 1 145 ? 9.90631   -18.25707 67.07332 1.000 30.68836  ? 141 PHE C C   1 
ATOM   3243 O  O   . PHE C 1 145 ? 9.05280   -18.46971 67.94286 1.000 32.99808  ? 141 PHE C O   1 
ATOM   3244 C  CB  . PHE C 1 145 ? 9.11192   -17.35186 64.87197 1.000 22.33400  ? 141 PHE C CB  1 
ATOM   3245 C  CG  . PHE C 1 145 ? 7.65337   -17.68157 65.02664 1.000 24.54071  ? 141 PHE C CG  1 
ATOM   3246 C  CD1 . PHE C 1 145 ? 6.71926   -16.67789 65.22794 1.000 28.10439  ? 141 PHE C CD1 1 
ATOM   3247 C  CD2 . PHE C 1 145 ? 7.21416   -18.99392 64.95567 1.000 31.59012  ? 141 PHE C CD2 1 
ATOM   3248 C  CE1 . PHE C 1 145 ? 5.37488   -16.97782 65.36460 1.000 34.89635  ? 141 PHE C CE1 1 
ATOM   3249 C  CE2 . PHE C 1 145 ? 5.87116   -19.30037 65.09107 1.000 32.73824  ? 141 PHE C CE2 1 
ATOM   3250 C  CZ  . PHE C 1 145 ? 4.95106   -18.29095 65.29623 1.000 29.73748  ? 141 PHE C CZ  1 
ATOM   3251 N  N   . VAL C 1 146 ? 10.93353  -19.08416 66.86574 1.000 26.90629  ? 142 VAL C N   1 
ATOM   3252 C  CA  . VAL C 1 146 ? 11.12904  -20.26423 67.70639 1.000 36.43553  ? 142 VAL C CA  1 
ATOM   3253 C  C   . VAL C 1 146 ? 11.29276  -19.85145 69.16263 1.000 27.42398  ? 142 VAL C C   1 
ATOM   3254 O  O   . VAL C 1 146 ? 10.50204  -20.23886 70.03021 1.000 31.38977  ? 142 VAL C O   1 
ATOM   3255 C  CB  . VAL C 1 146 ? 12.33962  -21.08044 67.22130 1.000 38.77584  ? 142 VAL C CB  1 
ATOM   3256 C  CG1 . VAL C 1 146 ? 12.50721  -22.33338 68.06365 1.000 36.79442  ? 142 VAL C CG1 1 
ATOM   3257 C  CG2 . VAL C 1 146 ? 12.17787  -21.44441 65.76986 1.000 32.17130  ? 142 VAL C CG2 1 
ATOM   3258 N  N   . GLN C 1 147 ? 12.31944  -19.04166 69.44230 1.000 35.29760  ? 143 GLN C N   1 
ATOM   3259 C  CA  . GLN C 1 147 ? 12.62576  -18.64685 70.81470 1.000 40.96792  ? 143 GLN C CA  1 
ATOM   3260 C  C   . GLN C 1 147 ? 11.41508  -18.03197 71.50691 1.000 43.51364  ? 143 GLN C C   1 
ATOM   3261 O  O   . GLN C 1 147 ? 11.21379  -18.22453 72.71147 1.000 44.33884  ? 143 GLN C O   1 
ATOM   3262 C  CB  . GLN C 1 147 ? 13.80425  -17.67177 70.81847 1.000 36.59908  ? 143 GLN C CB  1 
ATOM   3263 C  CG  . GLN C 1 147 ? 15.10181  -18.27914 70.30224 1.000 42.84366  ? 143 GLN C CG  1 
ATOM   3264 C  CD  . GLN C 1 147 ? 16.27554  -17.32250 70.38717 1.000 40.87819  ? 143 GLN C CD  1 
ATOM   3265 O  OE1 . GLN C 1 147 ? 16.47420  -16.65443 71.40083 1.000 31.23269  ? 143 GLN C OE1 1 
ATOM   3266 N  NE2 . GLN C 1 147 ? 17.05969  -17.25119 69.31739 1.000 30.58874  ? 143 GLN C NE2 1 
HETATM 3267 N  N   . MSE C 1 148 ? 10.59426  -17.29877 70.76176 1.000 39.50273  ? 144 MSE C N   1 
HETATM 3268 C  CA  . MSE C 1 148 ? 9.34804   -16.76138 71.29700 1.000 40.44365  ? 144 MSE C CA  1 
HETATM 3269 C  C   . MSE C 1 148 ? 8.35267   -17.88643 71.57571 1.000 47.23190  ? 144 MSE C C   1 
HETATM 3270 O  O   . MSE C 1 148 ? 7.67314   -17.88823 72.60261 1.000 49.27832  ? 144 MSE C O   1 
HETATM 3271 C  CB  . MSE C 1 148 ? 8.74714   -15.74152 70.32615 1.000 32.10473  ? 144 MSE C CB  1 
HETATM 3272 C  CG  . MSE C 1 148 ? 7.23466   -15.62481 70.39251 1.000 48.88016  ? 144 MSE C CG  1 
HETATM 3273 SE SE  . MSE C 1 148 ? 6.57531   -13.85764 69.90468 1.000 113.09161 ? 144 MSE C SE  1 
HETATM 3274 C  CE  . MSE C 1 148 ? 7.30378   -12.84015 71.40113 1.000 57.28978  ? 144 MSE C CE  1 
HETATM 3275 N  N   . MSE C 1 149 ? 8.28368   -18.84623 70.65800 1.000 44.71641  ? 145 MSE C N   1 
HETATM 3276 C  CA  . MSE C 1 149 ? 7.33898   -19.95433 70.76262 1.000 44.93153  ? 145 MSE C CA  1 
HETATM 3277 C  C   . MSE C 1 149 ? 7.66366   -20.90387 71.91285 1.000 51.24270  ? 145 MSE C C   1 
HETATM 3278 O  O   . MSE C 1 149 ? 6.79542   -21.23027 72.72076 1.000 53.41183  ? 145 MSE C O   1 
HETATM 3279 C  CB  . MSE C 1 149 ? 7.29980   -20.74139 69.45030 1.000 39.09473  ? 145 MSE C CB  1 
HETATM 3280 C  CG  . MSE C 1 149 ? 6.24145   -20.27764 68.46203 1.000 47.03385  ? 145 MSE C CG  1 
HETATM 3281 SE SE  . MSE C 1 149 ? 4.55934   -19.76259 69.30364 1.000 75.98577  ? 145 MSE C SE  1 
HETATM 3282 C  CE  . MSE C 1 149 ? 4.76327   -17.82748 69.27417 1.000 58.34588  ? 145 MSE C CE  1 
ATOM   3283 N  N   . THR C 1 150 ? 8.91375   -21.34711 71.98048 1.000 49.76187  ? 146 THR C N   1 
ATOM   3284 C  CA  . THR C 1 150 ? 9.32423   -22.35046 72.94562 1.000 51.02418  ? 146 THR C CA  1 
ATOM   3285 C  C   . THR C 1 150 ? 10.09885  -21.69735 74.08907 1.000 62.93196  ? 146 THR C C   1 
ATOM   3286 O  O   . THR C 1 150 ? 10.13733  -20.47138 74.22914 1.000 62.95017  ? 146 THR C O   1 
ATOM   3287 C  CB  . THR C 1 150 ? 10.15256  -23.43557 72.25308 1.000 57.57979  ? 146 THR C CB  1 
ATOM   3288 O  OG1 . THR C 1 150 ? 10.63208  -24.37068 73.22807 1.000 64.85292  ? 146 THR C OG1 1 
ATOM   3289 C  CG2 . THR C 1 150 ? 11.33934  -22.82107 71.53401 1.000 54.03471  ? 146 THR C CG2 1 
ATOM   3290 N  N   . ALA C 1 151 ? 10.72441  -22.52776 74.92365 1.000 59.19234  ? 147 ALA C N   1 
ATOM   3291 C  CA  . ALA C 1 151 ? 11.54441  -22.04084 76.02426 1.000 64.47824  ? 147 ALA C CA  1 
ATOM   3292 C  C   . ALA C 1 151 ? 12.90337  -21.52914 75.56641 1.000 64.05559  ? 147 ALA C C   1 
ATOM   3293 O  O   . ALA C 1 151 ? 13.64091  -20.96470 76.38193 1.000 52.19579  ? 147 ALA C O   1 
ATOM   3294 C  CB  . ALA C 1 151 ? 11.73310  -23.14593 77.06591 1.000 65.24779  ? 147 ALA C CB  1 
ATOM   3295 N  N   . LYS C 1 152 ? 13.24685  -21.71116 74.29443 1.000 67.10966  ? 148 LYS C N   1 
ATOM   3296 C  CA  . LYS C 1 152 ? 14.51586  -21.24290 73.74915 1.000 58.54423  ? 148 LYS C CA  1 
ATOM   3297 C  C   . LYS C 1 152 ? 14.62323  -19.72300 73.82400 1.000 48.67134  ? 148 LYS C C   1 
ATOM   3298 O  O   . LYS C 1 152 ? 13.62294  -19.02728 74.00022 1.000 51.05532  ? 148 LYS C O   1 
ATOM   3299 C  CB  . LYS C 1 152 ? 14.67271  -21.71024 72.29992 1.000 56.95175  ? 148 LYS C CB  1 
ATOM   3300 C  CG  . LYS C 1 152 ? 16.07574  -21.56882 71.73167 1.000 55.08685  ? 148 LYS C CG  1 
ATOM   3301 C  CD  . LYS C 1 152 ? 16.13486  -22.03312 70.27975 1.000 48.88443  ? 148 LYS C CD  1 
ATOM   3302 C  CE  . LYS C 1 152 ? 16.15336  -23.55397 70.16638 1.000 56.01353  ? 148 LYS C CE  1 
ATOM   3303 N  NZ  . LYS C 1 152 ? 14.79920  -24.17136 70.25292 1.000 56.31701  ? 148 LYS C NZ  1 
HETATM 3304 CA CA  . CA  D 2 .   ? -26.18013 4.95642   18.58258 1.000 42.22162  ? 201 CA  A CA  1 
HETATM 3305 CA CA  . CA  E 2 .   ? -31.50039 -3.24257  24.95873 1.000 39.06706  ? 202 CA  A CA  1 
HETATM 3306 CA CA  . CA  F 2 .   ? -7.80477  -11.11343 -2.19537 1.000 24.09397  ? 203 CA  A CA  1 
HETATM 3307 CA CA  . CA  G 2 .   ? -1.92730  -16.57433 6.02363  1.000 18.21004  ? 204 CA  A CA  1 
HETATM 3308 C  C1  . KN9 H 3 .   ? -13.03430 -9.59981  16.31067 1.000 63.56457  ? 205 KN9 A C1  1 
HETATM 3309 C  C10 . KN9 H 3 .   ? -8.86072  -9.30393  11.27529 1.000 36.68717  ? 205 KN9 A C10 1 
HETATM 3310 C  C11 . KN9 H 3 .   ? -14.14553 -9.71475  14.12534 1.000 69.34580  ? 205 KN9 A C11 1 
HETATM 3311 C  C12 . KN9 H 3 .   ? -15.60026 -10.04408 14.41178 1.000 74.48263  ? 205 KN9 A C12 1 
HETATM 3312 C  C13 . KN9 H 3 .   ? -15.88790 -11.20402 15.10516 1.000 72.32408  ? 205 KN9 A C13 1 
HETATM 3313 C  C14 . KN9 H 3 .   ? -17.19425 -11.57119 15.38193 1.000 64.01448  ? 205 KN9 A C14 1 
HETATM 3314 C  C15 . KN9 H 3 .   ? -18.23860 -10.78250 14.94832 1.000 71.11473  ? 205 KN9 A C15 1 
HETATM 3315 C  C16 . KN9 H 3 .   ? -17.97078 -9.62445  14.24723 1.000 75.05226  ? 205 KN9 A C16 1 
HETATM 3316 C  C17 . KN9 H 3 .   ? -16.65818 -9.24725  13.95925 1.000 74.34176  ? 205 KN9 A C17 1 
HETATM 3317 C  C18 . KN9 H 3 .   ? -15.98303 -6.85468  13.94651 1.000 79.09945  ? 205 KN9 A C18 1 
HETATM 3318 C  C19 . KN9 H 3 .   ? -17.96018 -9.02314  11.10231 1.000 77.79566  ? 205 KN9 A C19 1 
HETATM 3319 C  C2  . KN9 H 3 .   ? -12.29757 -8.16680  14.54515 1.000 65.27728  ? 205 KN9 A C2  1 
HETATM 3320 C  C20 . KN9 H 3 .   ? -17.67846 -10.30820 10.68064 1.000 75.51832  ? 205 KN9 A C20 1 
HETATM 3321 C  C21 . KN9 H 3 .   ? -18.70533 -11.14745 10.29202 1.000 72.05276  ? 205 KN9 A C21 1 
HETATM 3322 C  C22 . KN9 H 3 .   ? -20.01871 -10.69804 10.32587 1.000 80.90572  ? 205 KN9 A C22 1 
HETATM 3323 C  C23 . KN9 H 3 .   ? -20.29678 -9.40699  10.75068 1.000 77.15530  ? 205 KN9 A C23 1 
HETATM 3324 C  C24 . KN9 H 3 .   ? -19.26671 -8.57158  11.13784 1.000 66.18473  ? 205 KN9 A C24 1 
HETATM 3325 C  C26 . KN9 H 3 .   ? -21.47128 -11.43335 8.58731  1.000 65.46473  ? 205 KN9 A C26 1 
HETATM 3326 C  C27 . KN9 H 3 .   ? -17.15703 -6.14764  14.62085 1.000 69.65839  ? 205 KN9 A C27 1 
HETATM 3327 C  C3  . KN9 H 3 .   ? -11.86226 -8.75413  13.21917 1.000 61.05416  ? 205 KN9 A C3  1 
HETATM 3328 C  C4  . KN9 H 3 .   ? -10.70487 -8.37896  12.68117 1.000 53.87577  ? 205 KN9 A C4  1 
HETATM 3329 C  C5  . KN9 H 3 .   ? -10.19021 -8.88390  11.38083 1.000 43.57373  ? 205 KN9 A C5  1 
HETATM 3330 C  C6  . KN9 H 3 .   ? -11.00307 -8.91829  10.24542 1.000 34.86337  ? 205 KN9 A C6  1 
HETATM 3331 C  C7  . KN9 H 3 .   ? -10.49736 -9.37826  9.04340  1.000 31.47843  ? 205 KN9 A C7  1 
HETATM 3332 C  C8  . KN9 H 3 .   ? -9.18096  -9.80024  8.95385  1.000 41.88248  ? 205 KN9 A C8  1 
HETATM 3333 C  C9  . KN9 H 3 .   ? -8.36395  -9.76302  10.07083 1.000 30.57473  ? 205 KN9 A C9  1 
HETATM 3334 N  N1  . KN9 H 3 .   ? -13.46357 -8.85708  15.12291 1.000 73.73316  ? 205 KN9 A N1  1 
HETATM 3335 N  N2  . KN9 H 3 .   ? -16.43222 -8.05964  13.24234 1.000 82.60544  ? 205 KN9 A N2  1 
HETATM 3336 O  O1  . KN9 H 3 .   ? -17.60163 -6.92015  15.73685 1.000 64.71685  ? 205 KN9 A O1  1 
HETATM 3337 O  O2  . KN9 H 3 .   ? -17.13199 -6.63321  11.37294 1.000 71.72875  ? 205 KN9 A O2  1 
HETATM 3338 O  O25 . KN9 H 3 .   ? -21.03090 -11.52217 9.94503  1.000 74.92402  ? 205 KN9 A O25 1 
HETATM 3339 O  O3  . KN9 H 3 .   ? -15.46902 -8.45588  10.99633 1.000 71.81220  ? 205 KN9 A O3  1 
HETATM 3340 S  S   . KN9 H 3 .   ? -16.65326 -7.95201  11.60091 1.000 89.11442  ? 205 KN9 A S   1 
HETATM 3341 CL CL  . KN9 H 3 .   ? -8.56302  -10.37418 7.43748  1.000 51.05248  ? 205 KN9 A CL  1 
HETATM 3342 CA CA  . CA  I 2 .   ? -25.15267 5.42152   38.84616 1.000 46.87917  ? 201 CA  B CA  1 
HETATM 3343 CA CA  . CA  J 2 .   ? -15.53895 6.15346   32.19923 1.000 52.39630  ? 202 CA  B CA  1 
HETATM 3344 CA CA  . CA  K 2 .   ? -20.42116 -18.54132 59.68953 1.000 22.14471  ? 203 CA  B CA  1 
HETATM 3345 CA CA  . CA  L 2 .   ? -18.57650 -26.24093 51.39435 1.000 23.43065  ? 204 CA  B CA  1 
HETATM 3346 C  C1  . KN9 M 3 .   ? -19.09832 -13.53944 41.85736 1.000 77.19488  ? 205 KN9 B C1  1 
HETATM 3347 C  C10 . KN9 M 3 .   ? -20.64728 -14.77401 46.98703 1.000 53.82033  ? 205 KN9 B C10 1 
HETATM 3348 C  C11 . KN9 M 3 .   ? -19.51769 -11.91010 43.62138 1.000 80.83009  ? 205 KN9 B C11 1 
HETATM 3349 C  C12 . KN9 M 3 .   ? -19.00528 -10.53727 43.25506 1.000 85.18790  ? 205 KN9 B C12 1 
HETATM 3350 C  C13 . KN9 M 3 .   ? -17.87008 -10.41556 42.47303 1.000 79.23905  ? 205 KN9 B C13 1 
HETATM 3351 C  C14 . KN9 M 3 .   ? -17.37983 -9.17009  42.12889 1.000 78.68868  ? 205 KN9 B C14 1 
HETATM 3352 C  C15 . KN9 M 3 .   ? -18.01961 -8.03087  42.57581 1.000 83.40625  ? 205 KN9 B C15 1 
HETATM 3353 C  C16 . KN9 M 3 .   ? -19.15006 -8.13901  43.36337 1.000 87.09326  ? 205 KN9 B C16 1 
HETATM 3354 C  C17 . KN9 M 3 .   ? -19.65434 -9.38773  43.71121 1.000 90.76012  ? 205 KN9 B C17 1 
HETATM 3355 C  C18 . KN9 M 3 .   ? -22.14854 -9.29281  43.96514 1.000 81.29248  ? 205 KN9 B C18 1 
HETATM 3356 C  C19 . KN9 M 3 .   ? -19.05135 -9.05936  46.59540 1.000 77.99339  ? 205 KN9 B C19 1 
HETATM 3357 C  C2  . KN9 M 3 .   ? -21.26226 -13.42511 42.90305 1.000 76.00717  ? 205 KN9 B C2  1 
HETATM 3358 C  C20 . KN9 M 3 .   ? -17.99766 -9.93404  46.77811 1.000 78.17485  ? 205 KN9 B C20 1 
HETATM 3359 C  C21 . KN9 M 3 .   ? -16.75012 -9.44746  47.12007 1.000 80.53482  ? 205 KN9 B C21 1 
HETATM 3360 C  C22 . KN9 M 3 .   ? -16.55694 -8.08176  47.27556 1.000 75.22355  ? 205 KN9 B C22 1 
HETATM 3361 C  C23 . KN9 M 3 .   ? -17.61578 -7.20688  47.08810 1.000 72.41490  ? 205 KN9 B C23 1 
HETATM 3362 C  C24 . KN9 M 3 .   ? -18.86102 -7.69801  46.74845 1.000 81.33992  ? 205 KN9 B C24 1 
HETATM 3363 C  C26 . KN9 M 3 .   ? -15.23454 -6.86669  48.83347 1.000 61.27473  ? 205 KN9 B C26 1 
HETATM 3364 C  C27 . KN9 M 3 .   ? -22.23359 -9.79434  42.52437 1.000 76.51908  ? 205 KN9 B C27 1 
HETATM 3365 C  C3  . KN9 M 3 .   ? -21.09642 -13.92191 44.31907 1.000 66.67325  ? 205 KN9 B C3  1 
HETATM 3366 C  C4  . KN9 M 3 .   ? -21.20801 -15.21179 44.59928 1.000 60.88361  ? 205 KN9 B C4  1 
HETATM 3367 C  C5  . KN9 M 3 .   ? -21.04381 -15.67338 45.99510 1.000 58.49961  ? 205 KN9 B C5  1 
HETATM 3368 C  C6  . KN9 M 3 .   ? -21.28939 -17.00639 46.32511 1.000 46.82941  ? 205 KN9 B C6  1 
HETATM 3369 C  C7  . KN9 M 3 .   ? -21.13598 -17.42959 47.62931 1.000 43.38473  ? 205 KN9 B C7  1 
HETATM 3370 C  C8  . KN9 M 3 .   ? -20.74105 -16.53248 48.60760 1.000 45.14138  ? 205 KN9 B C8  1 
HETATM 3371 C  C9  . KN9 M 3 .   ? -20.49719 -15.20846 48.28695 1.000 43.71473  ? 205 KN9 B C9  1 
HETATM 3372 N  N1  . KN9 M 3 .   ? -20.08659 -12.64700 42.48178 1.000 82.73432  ? 205 KN9 B N1  1 
HETATM 3373 N  N2  . KN9 M 3 .   ? -20.79965 -9.45044  44.52065 1.000 92.72058  ? 205 KN9 B N2  1 
HETATM 3374 O  O1  . KN9 M 3 .   ? -23.14181 -10.89611 42.47186 1.000 73.63801  ? 205 KN9 B O1  1 
HETATM 3375 O  O2  . KN9 M 3 .   ? -20.62817 -11.07124 46.39222 1.000 84.05611  ? 205 KN9 B O2  1 
HETATM 3376 O  O25 . KN9 M 3 .   ? -15.33080 -7.60258  47.61132 1.000 68.54653  ? 205 KN9 B O25 1 
HETATM 3377 O  O3  . KN9 M 3 .   ? -21.58722 -8.79870  46.76611 1.000 83.33266  ? 205 KN9 B O3  1 
HETATM 3378 S  S   . KN9 M 3 .   ? -20.64406 -9.67028  46.15683 1.000 92.66072  ? 205 KN9 B S   1 
HETATM 3379 CL CL  . KN9 M 3 .   ? -20.55165 -17.07345 50.24343 1.000 54.45185  ? 205 KN9 B CL  1 
HETATM 3380 CA CA  . CA  N 2 .   ? -16.70807 -19.96042 75.80865 1.000 38.32824  ? 201 CA  C CA  1 
HETATM 3381 CA CA  . CA  O 2 .   ? -11.81947 -28.13640 82.53118 1.000 36.68636  ? 202 CA  C CA  1 
HETATM 3382 CA CA  . CA  P 2 .   ? 6.37489   -12.08247 55.35195 1.000 26.50073  ? 203 CA  C CA  1 
HETATM 3383 CA CA  . CA  Q 2 .   ? 14.35522  -9.64412  63.44197 1.000 24.78829  ? 204 CA  C CA  1 
HETATM 3384 C  C1  . KN9 R 3 .   ? -0.17684  -25.34709 68.69499 1.000 90.33289  ? 205 KN9 C C1  1 
HETATM 3385 C  C10 . KN9 R 3 .   ? -5.55335  -26.61771 72.98106 1.000 64.85473  ? 205 KN9 C C10 1 
HETATM 3386 C  C11 . KN9 R 3 .   ? -1.10177  -24.53956 70.78292 1.000 100.35625 ? 205 KN9 C C11 1 
HETATM 3387 C  C12 . KN9 R 3 .   ? -0.05114  -23.49985 71.05610 1.000 94.64552  ? 205 KN9 C C12 1 
HETATM 3388 C  C13 . KN9 R 3 .   ? 1.18297   -23.93302 71.50417 1.000 101.66816 ? 205 KN9 C C13 1 
HETATM 3389 C  C14 . KN9 R 3 .   ? 2.18594   -23.02683 71.77481 1.000 101.79701 ? 205 KN9 C C14 1 
HETATM 3390 C  C15 . KN9 R 3 .   ? 1.94875   -21.67764 71.60440 1.000 97.33998  ? 205 KN9 C C15 1 
HETATM 3391 C  C16 . KN9 R 3 .   ? 0.71651   -21.23407 71.16486 1.000 100.79149 ? 205 KN9 C C16 1 
HETATM 3392 C  C17 . KN9 R 3 .   ? -0.30177  -22.13597 70.88596 1.000 99.78838  ? 205 KN9 C C17 1 
HETATM 3393 C  C18 . KN9 R 3 .   ? -2.68350  -21.53628 71.35817 1.000 91.84724  ? 205 KN9 C C18 1 
HETATM 3394 C  C19 . KN9 R 3 .   ? -0.59793  -19.89685 68.50363 1.000 97.63528  ? 205 KN9 C C19 1 
HETATM 3395 C  C2  . KN9 R 3 .   ? -2.51185  -25.62649 69.16201 1.000 83.94469  ? 205 KN9 C C2  1 
HETATM 3396 C  C20 . KN9 R 3 .   ? -0.88149  -18.59283 68.86328 1.000 94.39476  ? 205 KN9 C C20 1 
HETATM 3397 C  C21 . KN9 R 3 .   ? 0.02191   -17.58555 68.58458 1.000 87.42094  ? 205 KN9 C C21 1 
HETATM 3398 C  C22 . KN9 R 3 .   ? 1.21640   -17.88358 67.94223 1.000 88.14322  ? 205 KN9 C C22 1 
HETATM 3399 C  C23 . KN9 R 3 .   ? 1.49736   -19.19382 67.58175 1.000 88.77819  ? 205 KN9 C C23 1 
HETATM 3400 C  C24 . KN9 R 3 .   ? 0.59020   -20.19770 67.86308 1.000 93.23862  ? 205 KN9 C C24 1 
HETATM 3401 C  C26 . KN9 R 3 .   ? 1.96514   -15.65420 68.35973 1.000 82.41457  ? 205 KN9 C C26 1 
HETATM 3402 C  C27 . KN9 R 3 .   ? -2.52064  -20.38004 72.34822 1.000 88.96416  ? 205 KN9 C C27 1 
HETATM 3403 C  C3  . KN9 R 3 .   ? -3.51000  -25.34370 70.25268 1.000 79.25491  ? 205 KN9 C C3  1 
HETATM 3404 C  C4  . KN9 R 3 .   ? -3.94433  -26.26936 71.09428 1.000 71.79254  ? 205 KN9 C C4  1 
HETATM 3405 C  C5  . KN9 R 3 .   ? -4.90418  -25.76621 72.08898 1.000 67.53664  ? 205 KN9 C C5  1 
HETATM 3406 C  C6  . KN9 R 3 .   ? -5.14286  -24.39402 72.11380 1.000 64.03116  ? 205 KN9 C C6  1 
HETATM 3407 C  C7  . KN9 R 3 .   ? -6.02874  -23.86976 73.02224 1.000 62.23473  ? 205 KN9 C C7  1 
HETATM 3408 C  C8  . KN9 R 3 .   ? -6.67428  -24.71215 73.90646 1.000 63.49473  ? 205 KN9 C C8  1 
HETATM 3409 C  C9  . KN9 R 3 .   ? -6.44032  -26.07867 73.88837 1.000 62.47473  ? 205 KN9 C C9  1 
HETATM 3410 N  N1  . KN9 R 3 .   ? -1.34456  -24.75102 69.35057 1.000 95.38961  ? 205 KN9 C N1  1 
HETATM 3411 N  N2  . KN9 R 3 .   ? -1.54208  -21.64898 70.44017 1.000 104.00042 ? 205 KN9 C N2  1 
HETATM 3412 O  O1  . KN9 R 3 .   ? -1.66986  -19.37137 71.80529 1.000 90.99896  ? 205 KN9 C O1  1 
HETATM 3413 O  O2  . KN9 R 3 .   ? -3.03429  -20.56349 68.81668 1.000 95.77473  ? 205 KN9 C O2  1 
HETATM 3414 O  O25 . KN9 R 3 .   ? 2.10978   -16.89622 67.66361 1.000 81.39030  ? 205 KN9 C O25 1 
HETATM 3415 O  O3  . KN9 R 3 .   ? -1.39670  -22.28671 68.04688 1.000 99.23170  ? 205 KN9 C O3  1 
HETATM 3416 S  S   . KN9 R 3 .   ? -1.75373  -21.17884 68.86262 1.000 104.89643 ? 205 KN9 C S   1 
HETATM 3417 CL CL  . KN9 R 3 .   ? -7.78517  -24.02330 75.04071 1.000 64.44558  ? 205 KN9 C CL  1 
HETATM 3418 O  O   . HOH S 4 .   ? -21.36337 -19.13239 -0.26046 1.000 34.04351  ? 301 HOH A O   1 
HETATM 3419 O  O   . HOH S 4 .   ? -37.80107 -9.05912  6.26045  1.000 38.84782  ? 302 HOH A O   1 
HETATM 3420 O  O   . HOH S 4 .   ? -2.01005  -15.64897 14.09361 1.000 40.58469  ? 303 HOH A O   1 
HETATM 3421 O  O   . HOH S 4 .   ? -9.64595  -19.26984 17.50285 1.000 45.93794  ? 304 HOH A O   1 
HETATM 3422 O  O   . HOH S 4 .   ? -30.59611 -2.78270  4.20609  1.000 15.84167  ? 305 HOH A O   1 
HETATM 3423 O  O   . HOH S 4 .   ? -5.06936  -7.04303  -2.47380 1.000 25.77202  ? 306 HOH A O   1 
HETATM 3424 O  O   . HOH S 4 .   ? 2.09602   -12.35205 8.92202  1.000 30.16738  ? 307 HOH A O   1 
HETATM 3425 O  O   . HOH S 4 .   ? -7.41027  5.51548   8.36065  1.000 43.27001  ? 308 HOH A O   1 
HETATM 3426 O  O   . HOH S 4 .   ? -40.23118 -6.75101  6.32778  1.000 53.26354  ? 309 HOH A O   1 
HETATM 3427 O  O   . HOH S 4 .   ? -6.01919  -9.74877  -2.96231 1.000 26.77582  ? 310 HOH A O   1 
HETATM 3428 O  O   . HOH S 4 .   ? -6.69589  -16.49831 12.42859 1.000 27.23346  ? 311 HOH A O   1 
HETATM 3429 O  O   . HOH S 4 .   ? -2.63267  -17.69887 4.02849  1.000 19.19266  ? 312 HOH A O   1 
HETATM 3430 O  O   . HOH S 4 .   ? -2.136    -20.067   -3.031   1.000 17.92160  ? 313 HOH A O   1 
HETATM 3431 O  O   . HOH S 4 .   ? -13.37366 -16.32007 -6.28624 1.000 20.39312  ? 314 HOH A O   1 
HETATM 3432 O  O   . HOH S 4 .   ? -3.75236  -10.93878 -2.69766 1.000 27.86394  ? 315 HOH A O   1 
HETATM 3433 O  O   . HOH S 4 .   ? -24.20595 2.11929   4.59153  1.000 26.63162  ? 316 HOH A O   1 
HETATM 3434 O  O   . HOH S 4 .   ? -33.14020 0.46527   17.52825 1.000 32.85109  ? 317 HOH A O   1 
HETATM 3435 O  O   . HOH S 4 .   ? -20.85626 -12.01141 -1.25135 1.000 40.03650  ? 318 HOH A O   1 
HETATM 3436 O  O   . HOH S 4 .   ? -16.78022 4.09111   12.04072 1.000 38.44160  ? 319 HOH A O   1 
HETATM 3437 O  O   . HOH S 4 .   ? -8.72729  -19.36382 0.97934  1.000 21.89913  ? 320 HOH A O   1 
HETATM 3438 O  O   . HOH S 4 .   ? -0.05121  -19.14188 1.72722  1.000 24.05052  ? 321 HOH A O   1 
HETATM 3439 O  O   . HOH S 4 .   ? 5.16683   -14.11227 8.80293  1.000 36.93678  ? 322 HOH A O   1 
HETATM 3440 O  O   . HOH S 4 .   ? -20.74510 1.52748   8.10985  1.000 34.31050  ? 323 HOH A O   1 
HETATM 3441 O  O   . HOH S 4 .   ? -39.25131 -9.00275  12.53781 1.000 32.17205  ? 324 HOH A O   1 
HETATM 3442 O  O   . HOH S 4 .   ? -18.86229 -27.12333 13.31216 1.000 58.92795  ? 325 HOH A O   1 
HETATM 3443 O  O   . HOH S 4 .   ? -28.64000 -9.77799  26.30801 1.000 38.47544  ? 326 HOH A O   1 
HETATM 3444 O  O   . HOH S 4 .   ? -36.71481 -2.69518  4.46746  1.000 31.03242  ? 327 HOH A O   1 
HETATM 3445 O  O   . HOH S 4 .   ? -22.16547 -22.08805 2.80946  1.000 44.52718  ? 328 HOH A O   1 
HETATM 3446 O  O   . HOH S 4 .   ? -7.93897  -21.92012 3.65135  1.000 23.47798  ? 329 HOH A O   1 
HETATM 3447 O  O   . HOH S 4 .   ? -20.385   0.806     -0.487   1.000 26.84609  ? 330 HOH A O   1 
HETATM 3448 O  O   . HOH S 4 .   ? -23.331   0.502     0.102    1.000 16.52133  ? 331 HOH A O   1 
HETATM 3449 O  O   . HOH S 4 .   ? -1.69267  -5.14652  0.31872  1.000 26.88594  ? 332 HOH A O   1 
HETATM 3450 O  O   . HOH S 4 .   ? -13.57064 -16.53493 -2.04511 1.000 24.46790  ? 333 HOH A O   1 
HETATM 3451 O  O   . HOH S 4 .   ? -7.777    -11.794   -8.870   1.000 34.55718  ? 334 HOH A O   1 
HETATM 3452 O  O   . HOH S 4 .   ? -22.798   1.906     2.264    1.000 18.97119  ? 335 HOH A O   1 
HETATM 3453 O  O   . HOH S 4 .   ? -3.42410  -9.17249  -4.40495 1.000 31.16622  ? 336 HOH A O   1 
HETATM 3454 O  O   . HOH S 4 .   ? -7.22415  -21.27385 1.01673  1.000 28.60571  ? 337 HOH A O   1 
HETATM 3455 O  O   . HOH S 4 .   ? -18.70403 6.48914   4.57503  1.000 30.87221  ? 338 HOH A O   1 
HETATM 3456 O  O   . HOH S 4 .   ? -18.42382 7.30021   7.55036  1.000 43.49181  ? 339 HOH A O   1 
HETATM 3457 O  O   . HOH T 4 .   ? -19.24948 -25.85765 43.27488 1.000 37.42172  ? 301 HOH B O   1 
HETATM 3458 O  O   . HOH T 4 .   ? -13.41611 -19.68076 62.12892 1.000 23.40720  ? 302 HOH B O   1 
HETATM 3459 O  O   . HOH T 4 .   ? -23.99154 8.71415   41.94219 1.000 25.73847  ? 303 HOH B O   1 
HETATM 3460 O  O   . HOH T 4 .   ? -16.15490 -12.40174 60.85985 1.000 37.45425  ? 304 HOH B O   1 
HETATM 3461 O  O   . HOH T 4 .   ? -6.70504  -11.12048 58.08042 1.000 32.64391  ? 305 HOH B O   1 
HETATM 3462 O  O   . HOH T 4 .   ? -22.23539 -21.68333 60.01134 1.000 26.07311  ? 306 HOH B O   1 
HETATM 3463 O  O   . HOH T 4 .   ? -14.15621 -25.33260 39.55091 1.000 45.96307  ? 307 HOH B O   1 
HETATM 3464 O  O   . HOH T 4 .   ? -15.35912 -27.74292 60.56948 1.000 21.48994  ? 308 HOH B O   1 
HETATM 3465 O  O   . HOH T 4 .   ? -16.09866 5.56795   53.22555 1.000 26.14794  ? 309 HOH B O   1 
HETATM 3466 O  O   . HOH T 4 .   ? -17.02342 -26.30839 53.30560 1.000 20.87265  ? 310 HOH B O   1 
HETATM 3467 O  O   . HOH T 4 .   ? -19.58262 6.52718   31.43503 1.000 50.42974  ? 311 HOH B O   1 
HETATM 3468 O  O   . HOH T 4 .   ? -32.17527 -16.20647 52.49273 1.000 50.00211  ? 312 HOH B O   1 
HETATM 3469 O  O   . HOH T 4 .   ? -20.20103 -27.36284 57.36130 1.000 22.27069  ? 313 HOH B O   1 
HETATM 3470 O  O   . HOH T 4 .   ? -12.97392 -16.24413 63.69059 1.000 19.39199  ? 314 HOH B O   1 
HETATM 3471 O  O   . HOH T 4 .   ? -12.72601 -21.75272 56.47471 1.000 21.52030  ? 315 HOH B O   1 
HETATM 3472 O  O   . HOH T 4 .   ? -24.62099 -26.82381 48.42852 1.000 27.83557  ? 316 HOH B O   1 
HETATM 3473 O  O   . HOH T 4 .   ? -10.77897 -1.71282  54.52389 1.000 42.30050  ? 317 HOH B O   1 
HETATM 3474 O  O   . HOH T 4 .   ? -28.21990 -20.59834 56.81366 1.000 24.70408  ? 318 HOH B O   1 
HETATM 3475 O  O   . HOH T 4 .   ? -16.93351 -29.11167 55.84646 1.000 26.22570  ? 319 HOH B O   1 
HETATM 3476 O  O   . HOH T 4 .   ? -26.92403 6.91742   43.29511 1.000 35.58373  ? 320 HOH B O   1 
HETATM 3477 O  O   . HOH T 4 .   ? -10.78853 -23.82170 53.67523 1.000 21.73161  ? 321 HOH B O   1 
HETATM 3478 O  O   . HOH T 4 .   ? -22.22268 0.86617   57.43263 1.000 14.85492  ? 322 HOH B O   1 
HETATM 3479 O  O   . HOH T 4 .   ? -10.85012 9.84121   39.11936 1.000 44.53716  ? 323 HOH B O   1 
HETATM 3480 O  O   . HOH T 4 .   ? -20.43555 -0.80681  58.39523 1.000 38.85297  ? 324 HOH B O   1 
HETATM 3481 O  O   . HOH T 4 .   ? -26.03270 -23.36665 57.76631 1.000 39.19026  ? 325 HOH B O   1 
HETATM 3482 O  O   . HOH T 4 .   ? -24.11632 1.16766   55.22237 1.000 28.87245  ? 326 HOH B O   1 
HETATM 3483 O  O   . HOH T 4 .   ? -22.20431 9.13907   30.94561 1.000 53.25524  ? 327 HOH B O   1 
HETATM 3484 O  O   . HOH U 4 .   ? -12.69115 -26.30995 83.80656 1.000 39.56173  ? 301 HOH C O   1 
HETATM 3485 O  O   . HOH U 4 .   ? -18.82244 -22.73243 72.63186 1.000 23.21513  ? 302 HOH C O   1 
HETATM 3486 O  O   . HOH U 4 .   ? 1.75856   -26.94519 77.31000 1.000 51.52373  ? 303 HOH C O   1 
HETATM 3487 O  O   . HOH U 4 .   ? 15.66463  -2.10125  65.81957 1.000 32.12535  ? 304 HOH C O   1 
HETATM 3488 O  O   . HOH U 4 .   ? 9.20056   -18.50338 75.53294 1.000 58.14724  ? 305 HOH C O   1 
HETATM 3489 O  O   . HOH U 4 .   ? -17.95325 -27.24698 71.73872 1.000 38.02097  ? 306 HOH C O   1 
HETATM 3490 O  O   . HOH U 4 .   ? 8.508     -8.522    54.897   1.000 20.92595  ? 307 HOH C O   1 
HETATM 3491 O  O   . HOH U 4 .   ? 14.90491  -10.68405 61.36904 1.000 19.55159  ? 308 HOH C O   1 
HETATM 3492 O  O   . HOH U 4 .   ? 11.196    -17.479   52.802   1.000 29.65445  ? 309 HOH C O   1 
HETATM 3493 O  O   . HOH U 4 .   ? -11.98993 -34.16437 75.24156 1.000 45.24086  ? 310 HOH C O   1 
HETATM 3494 O  O   . HOH U 4 .   ? 4.46452   -8.21101  54.87573 1.000 24.38441  ? 311 HOH C O   1 
HETATM 3495 O  O   . HOH U 4 .   ? -12.24862 -14.61176 61.69117 1.000 37.29047  ? 312 HOH C O   1 
HETATM 3496 O  O   . HOH U 4 .   ? -18.43257 -21.50199 75.30804 1.000 34.73333  ? 313 HOH C O   1 
HETATM 3497 O  O   . HOH U 4 .   ? 6.34823   -9.75750  54.57177 1.000 23.16671  ? 314 HOH C O   1 
HETATM 3498 O  O   . HOH U 4 .   ? 17.430    -11.451   54.185   1.000 21.60509  ? 315 HOH C O   1 
HETATM 3499 O  O   . HOH U 4 .   ? 13.125    -16.904   58.405   1.000 25.68540  ? 316 HOH C O   1 
HETATM 3500 O  O   . HOH U 4 .   ? 7.44432   -4.79789  60.55036 1.000 33.46010  ? 317 HOH C O   1 
HETATM 3501 O  O   . HOH U 4 .   ? -12.15732 -27.32256 61.57864 1.000 27.65379  ? 318 HOH C O   1 
HETATM 3502 O  O   . HOH U 4 .   ? -15.93186 -28.39692 74.80374 1.000 33.07136  ? 319 HOH C O   1 
HETATM 3503 O  O   . HOH U 4 .   ? 17.586    -9.222    58.915   1.000 28.20159  ? 320 HOH C O   1 
HETATM 3504 O  O   . HOH U 4 .   ? 15.83582  -17.36427 60.99275 1.000 28.15568  ? 321 HOH C O   1 
HETATM 3505 O  O   . HOH U 4 .   ? 8.42262   -4.90178  73.40827 1.000 45.38163  ? 322 HOH C O   1 
HETATM 3506 O  O   . HOH U 4 .   ? -11.31484 -19.87170 57.46287 1.000 23.83868  ? 323 HOH C O   1 
HETATM 3507 O  O   . HOH U 4 .   ? -12.15153 -18.47552 59.41920 1.000 27.04075  ? 324 HOH C O   1 
HETATM 3508 O  O   . HOH U 4 .   ? -18.64261 -28.73086 74.95550 1.000 36.98883  ? 325 HOH C O   1 
# 
