data_9JPI
# 
_entry.id   9JPI 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9JPI         pdb_00009jpi 10.2210/pdb9jpi/pdb 
WWPDB D_1300051862 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-12-04 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9JPI 
_pdbx_database_status.recvd_initial_deposition_date   2024-09-26 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              jiahai@sioc.ac.cn 
_pdbx_contact_author.name_first         Jiahai 
_pdbx_contact_author.name_last          Zhou 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-5795-3804 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Zhou, J.' 1 ? 
'Zang, X.' 2 ? 
'Tang, Y.' 3 ? 
'Yan, Y.'  4 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Biodes Res' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2693-1257 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            6 
_citation.language                  ? 
_citation.page_first                0046 
_citation.page_last                 0046 
_citation.title                     'Structural Bases of Dihydroxy Acid Dehydratase Inhibition and Biodesign for Self-Resistance.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.34133/bdr.0046 
_citation.pdbx_database_id_PubMed   39494391 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Zang, X.'       1 ?                   
primary 'Bat-Erdene, U.' 2 ?                   
primary 'Huang, W.'      3 ?                   
primary 'Wu, Z.'         4 ?                   
primary 'Jacobsen, S.E.' 5 ?                   
primary 'Tang, Y.'       6 ?                   
primary 'Zhou, J.'       7 0009-0001-6673-1151 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Dihydroxy-acid dehydratase, chloroplastic' 61655.355 1   4.2.1.9 K559A,K560A ? ? 
2 non-polymer syn 'MAGNESIUM ION'                             24.305    1   ?       ?           ? ? 
3 non-polymer syn 'SULFATE ION'                               96.063    1   ?       ?           ? ? 
4 non-polymer syn 'Aspterric Acid'                            266.333   2   ?       ?           ? ? 
5 non-polymer syn 'FE2/S2 (INORGANIC) CLUSTER'                175.820   1   ?       ?           ? ? 
6 water       nat water                                       18.015    266 ?       ?           ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        AthDHAD,DAD 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GSIISCSAQSVTADPSPPITDTNKLNKYSSRITEPKSQGGSQAILHGVGLSDDDLLKPQIGISSVWYEGNTCNMHLLKLS
EAVKEGVENAGMVGFRFNTIGVSDAISMGTRGMCFSLQSRDLIADSIETVMSAQWYDGNISIPGCDKNMPGTIMAMGRLN
RPGIMVYGGTIKPGHFQDKTYDIVSAFQSYGEFVSGSISDEQRKTVLHHSCPGAGACGGMYTANTMASAIEAMGMSLPYS
SSIPAEDPLKLDECRLAGKYLLELLKMDLKPRDIITPKSLRNAMVSVMALGGSTNAVLHLIAIARSVGLELTLDDFQKVS
DAVPFLADLKPSGKYVMEDIHKIGGTPAVLRYLLELGLMDGDCMTVTGQTLAQNLENVPSLTEGQEIIRPLSNPIKETGH
IQILRGDLAPDGSVAKITGKEGLYFSGPALVFEGEESMLAAISADPMSFKGTVVVIRGEGPKGGPGMPEMLTPTSAIMGA
GLGKECALLTDGRFSGGSHGFVVGHICPEAQEGGPIGLIKNGDIITIDIGAARIDTQVSPEEMNDRRKKWTAPAYKVNRG
VLYKYIKNVQSASDGCVTDE
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GSIISCSAQSVTADPSPPITDTNKLNKYSSRITEPKSQGGSQAILHGVGLSDDDLLKPQIGISSVWYEGNTCNMHLLKLS
EAVKEGVENAGMVGFRFNTIGVSDAISMGTRGMCFSLQSRDLIADSIETVMSAQWYDGNISIPGCDKNMPGTIMAMGRLN
RPGIMVYGGTIKPGHFQDKTYDIVSAFQSYGEFVSGSISDEQRKTVLHHSCPGAGACGGMYTANTMASAIEAMGMSLPYS
SSIPAEDPLKLDECRLAGKYLLELLKMDLKPRDIITPKSLRNAMVSVMALGGSTNAVLHLIAIARSVGLELTLDDFQKVS
DAVPFLADLKPSGKYVMEDIHKIGGTPAVLRYLLELGLMDGDCMTVTGQTLAQNLENVPSLTEGQEIIRPLSNPIKETGH
IQILRGDLAPDGSVAKITGKEGLYFSGPALVFEGEESMLAAISADPMSFKGTVVVIRGEGPKGGPGMPEMLTPTSAIMGA
GLGKECALLTDGRFSGGSHGFVVGHICPEAQEGGPIGLIKNGDIITIDIGAARIDTQVSPEEMNDRRKKWTAPAYKVNRG
VLYKYIKNVQSASDGCVTDE
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'MAGNESIUM ION'              MG  
3 'SULFATE ION'                SO4 
4 'Aspterric Acid'             K0O 
5 'FE2/S2 (INORGANIC) CLUSTER' FES 
6 water                        HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   SER n 
1 3   ILE n 
1 4   ILE n 
1 5   SER n 
1 6   CYS n 
1 7   SER n 
1 8   ALA n 
1 9   GLN n 
1 10  SER n 
1 11  VAL n 
1 12  THR n 
1 13  ALA n 
1 14  ASP n 
1 15  PRO n 
1 16  SER n 
1 17  PRO n 
1 18  PRO n 
1 19  ILE n 
1 20  THR n 
1 21  ASP n 
1 22  THR n 
1 23  ASN n 
1 24  LYS n 
1 25  LEU n 
1 26  ASN n 
1 27  LYS n 
1 28  TYR n 
1 29  SER n 
1 30  SER n 
1 31  ARG n 
1 32  ILE n 
1 33  THR n 
1 34  GLU n 
1 35  PRO n 
1 36  LYS n 
1 37  SER n 
1 38  GLN n 
1 39  GLY n 
1 40  GLY n 
1 41  SER n 
1 42  GLN n 
1 43  ALA n 
1 44  ILE n 
1 45  LEU n 
1 46  HIS n 
1 47  GLY n 
1 48  VAL n 
1 49  GLY n 
1 50  LEU n 
1 51  SER n 
1 52  ASP n 
1 53  ASP n 
1 54  ASP n 
1 55  LEU n 
1 56  LEU n 
1 57  LYS n 
1 58  PRO n 
1 59  GLN n 
1 60  ILE n 
1 61  GLY n 
1 62  ILE n 
1 63  SER n 
1 64  SER n 
1 65  VAL n 
1 66  TRP n 
1 67  TYR n 
1 68  GLU n 
1 69  GLY n 
1 70  ASN n 
1 71  THR n 
1 72  CYS n 
1 73  ASN n 
1 74  MET n 
1 75  HIS n 
1 76  LEU n 
1 77  LEU n 
1 78  LYS n 
1 79  LEU n 
1 80  SER n 
1 81  GLU n 
1 82  ALA n 
1 83  VAL n 
1 84  LYS n 
1 85  GLU n 
1 86  GLY n 
1 87  VAL n 
1 88  GLU n 
1 89  ASN n 
1 90  ALA n 
1 91  GLY n 
1 92  MET n 
1 93  VAL n 
1 94  GLY n 
1 95  PHE n 
1 96  ARG n 
1 97  PHE n 
1 98  ASN n 
1 99  THR n 
1 100 ILE n 
1 101 GLY n 
1 102 VAL n 
1 103 SER n 
1 104 ASP n 
1 105 ALA n 
1 106 ILE n 
1 107 SER n 
1 108 MET n 
1 109 GLY n 
1 110 THR n 
1 111 ARG n 
1 112 GLY n 
1 113 MET n 
1 114 CYS n 
1 115 PHE n 
1 116 SER n 
1 117 LEU n 
1 118 GLN n 
1 119 SER n 
1 120 ARG n 
1 121 ASP n 
1 122 LEU n 
1 123 ILE n 
1 124 ALA n 
1 125 ASP n 
1 126 SER n 
1 127 ILE n 
1 128 GLU n 
1 129 THR n 
1 130 VAL n 
1 131 MET n 
1 132 SER n 
1 133 ALA n 
1 134 GLN n 
1 135 TRP n 
1 136 TYR n 
1 137 ASP n 
1 138 GLY n 
1 139 ASN n 
1 140 ILE n 
1 141 SER n 
1 142 ILE n 
1 143 PRO n 
1 144 GLY n 
1 145 CYS n 
1 146 ASP n 
1 147 LYS n 
1 148 ASN n 
1 149 MET n 
1 150 PRO n 
1 151 GLY n 
1 152 THR n 
1 153 ILE n 
1 154 MET n 
1 155 ALA n 
1 156 MET n 
1 157 GLY n 
1 158 ARG n 
1 159 LEU n 
1 160 ASN n 
1 161 ARG n 
1 162 PRO n 
1 163 GLY n 
1 164 ILE n 
1 165 MET n 
1 166 VAL n 
1 167 TYR n 
1 168 GLY n 
1 169 GLY n 
1 170 THR n 
1 171 ILE n 
1 172 LYS n 
1 173 PRO n 
1 174 GLY n 
1 175 HIS n 
1 176 PHE n 
1 177 GLN n 
1 178 ASP n 
1 179 LYS n 
1 180 THR n 
1 181 TYR n 
1 182 ASP n 
1 183 ILE n 
1 184 VAL n 
1 185 SER n 
1 186 ALA n 
1 187 PHE n 
1 188 GLN n 
1 189 SER n 
1 190 TYR n 
1 191 GLY n 
1 192 GLU n 
1 193 PHE n 
1 194 VAL n 
1 195 SER n 
1 196 GLY n 
1 197 SER n 
1 198 ILE n 
1 199 SER n 
1 200 ASP n 
1 201 GLU n 
1 202 GLN n 
1 203 ARG n 
1 204 LYS n 
1 205 THR n 
1 206 VAL n 
1 207 LEU n 
1 208 HIS n 
1 209 HIS n 
1 210 SER n 
1 211 CYS n 
1 212 PRO n 
1 213 GLY n 
1 214 ALA n 
1 215 GLY n 
1 216 ALA n 
1 217 CYS n 
1 218 GLY n 
1 219 GLY n 
1 220 MET n 
1 221 TYR n 
1 222 THR n 
1 223 ALA n 
1 224 ASN n 
1 225 THR n 
1 226 MET n 
1 227 ALA n 
1 228 SER n 
1 229 ALA n 
1 230 ILE n 
1 231 GLU n 
1 232 ALA n 
1 233 MET n 
1 234 GLY n 
1 235 MET n 
1 236 SER n 
1 237 LEU n 
1 238 PRO n 
1 239 TYR n 
1 240 SER n 
1 241 SER n 
1 242 SER n 
1 243 ILE n 
1 244 PRO n 
1 245 ALA n 
1 246 GLU n 
1 247 ASP n 
1 248 PRO n 
1 249 LEU n 
1 250 LYS n 
1 251 LEU n 
1 252 ASP n 
1 253 GLU n 
1 254 CYS n 
1 255 ARG n 
1 256 LEU n 
1 257 ALA n 
1 258 GLY n 
1 259 LYS n 
1 260 TYR n 
1 261 LEU n 
1 262 LEU n 
1 263 GLU n 
1 264 LEU n 
1 265 LEU n 
1 266 LYS n 
1 267 MET n 
1 268 ASP n 
1 269 LEU n 
1 270 LYS n 
1 271 PRO n 
1 272 ARG n 
1 273 ASP n 
1 274 ILE n 
1 275 ILE n 
1 276 THR n 
1 277 PRO n 
1 278 LYS n 
1 279 SER n 
1 280 LEU n 
1 281 ARG n 
1 282 ASN n 
1 283 ALA n 
1 284 MET n 
1 285 VAL n 
1 286 SER n 
1 287 VAL n 
1 288 MET n 
1 289 ALA n 
1 290 LEU n 
1 291 GLY n 
1 292 GLY n 
1 293 SER n 
1 294 THR n 
1 295 ASN n 
1 296 ALA n 
1 297 VAL n 
1 298 LEU n 
1 299 HIS n 
1 300 LEU n 
1 301 ILE n 
1 302 ALA n 
1 303 ILE n 
1 304 ALA n 
1 305 ARG n 
1 306 SER n 
1 307 VAL n 
1 308 GLY n 
1 309 LEU n 
1 310 GLU n 
1 311 LEU n 
1 312 THR n 
1 313 LEU n 
1 314 ASP n 
1 315 ASP n 
1 316 PHE n 
1 317 GLN n 
1 318 LYS n 
1 319 VAL n 
1 320 SER n 
1 321 ASP n 
1 322 ALA n 
1 323 VAL n 
1 324 PRO n 
1 325 PHE n 
1 326 LEU n 
1 327 ALA n 
1 328 ASP n 
1 329 LEU n 
1 330 LYS n 
1 331 PRO n 
1 332 SER n 
1 333 GLY n 
1 334 LYS n 
1 335 TYR n 
1 336 VAL n 
1 337 MET n 
1 338 GLU n 
1 339 ASP n 
1 340 ILE n 
1 341 HIS n 
1 342 LYS n 
1 343 ILE n 
1 344 GLY n 
1 345 GLY n 
1 346 THR n 
1 347 PRO n 
1 348 ALA n 
1 349 VAL n 
1 350 LEU n 
1 351 ARG n 
1 352 TYR n 
1 353 LEU n 
1 354 LEU n 
1 355 GLU n 
1 356 LEU n 
1 357 GLY n 
1 358 LEU n 
1 359 MET n 
1 360 ASP n 
1 361 GLY n 
1 362 ASP n 
1 363 CYS n 
1 364 MET n 
1 365 THR n 
1 366 VAL n 
1 367 THR n 
1 368 GLY n 
1 369 GLN n 
1 370 THR n 
1 371 LEU n 
1 372 ALA n 
1 373 GLN n 
1 374 ASN n 
1 375 LEU n 
1 376 GLU n 
1 377 ASN n 
1 378 VAL n 
1 379 PRO n 
1 380 SER n 
1 381 LEU n 
1 382 THR n 
1 383 GLU n 
1 384 GLY n 
1 385 GLN n 
1 386 GLU n 
1 387 ILE n 
1 388 ILE n 
1 389 ARG n 
1 390 PRO n 
1 391 LEU n 
1 392 SER n 
1 393 ASN n 
1 394 PRO n 
1 395 ILE n 
1 396 LYS n 
1 397 GLU n 
1 398 THR n 
1 399 GLY n 
1 400 HIS n 
1 401 ILE n 
1 402 GLN n 
1 403 ILE n 
1 404 LEU n 
1 405 ARG n 
1 406 GLY n 
1 407 ASP n 
1 408 LEU n 
1 409 ALA n 
1 410 PRO n 
1 411 ASP n 
1 412 GLY n 
1 413 SER n 
1 414 VAL n 
1 415 ALA n 
1 416 LYS n 
1 417 ILE n 
1 418 THR n 
1 419 GLY n 
1 420 LYS n 
1 421 GLU n 
1 422 GLY n 
1 423 LEU n 
1 424 TYR n 
1 425 PHE n 
1 426 SER n 
1 427 GLY n 
1 428 PRO n 
1 429 ALA n 
1 430 LEU n 
1 431 VAL n 
1 432 PHE n 
1 433 GLU n 
1 434 GLY n 
1 435 GLU n 
1 436 GLU n 
1 437 SER n 
1 438 MET n 
1 439 LEU n 
1 440 ALA n 
1 441 ALA n 
1 442 ILE n 
1 443 SER n 
1 444 ALA n 
1 445 ASP n 
1 446 PRO n 
1 447 MET n 
1 448 SER n 
1 449 PHE n 
1 450 LYS n 
1 451 GLY n 
1 452 THR n 
1 453 VAL n 
1 454 VAL n 
1 455 VAL n 
1 456 ILE n 
1 457 ARG n 
1 458 GLY n 
1 459 GLU n 
1 460 GLY n 
1 461 PRO n 
1 462 LYS n 
1 463 GLY n 
1 464 GLY n 
1 465 PRO n 
1 466 GLY n 
1 467 MET n 
1 468 PRO n 
1 469 GLU n 
1 470 MET n 
1 471 LEU n 
1 472 THR n 
1 473 PRO n 
1 474 THR n 
1 475 SER n 
1 476 ALA n 
1 477 ILE n 
1 478 MET n 
1 479 GLY n 
1 480 ALA n 
1 481 GLY n 
1 482 LEU n 
1 483 GLY n 
1 484 LYS n 
1 485 GLU n 
1 486 CYS n 
1 487 ALA n 
1 488 LEU n 
1 489 LEU n 
1 490 THR n 
1 491 ASP n 
1 492 GLY n 
1 493 ARG n 
1 494 PHE n 
1 495 SER n 
1 496 GLY n 
1 497 GLY n 
1 498 SER n 
1 499 HIS n 
1 500 GLY n 
1 501 PHE n 
1 502 VAL n 
1 503 VAL n 
1 504 GLY n 
1 505 HIS n 
1 506 ILE n 
1 507 CYS n 
1 508 PRO n 
1 509 GLU n 
1 510 ALA n 
1 511 GLN n 
1 512 GLU n 
1 513 GLY n 
1 514 GLY n 
1 515 PRO n 
1 516 ILE n 
1 517 GLY n 
1 518 LEU n 
1 519 ILE n 
1 520 LYS n 
1 521 ASN n 
1 522 GLY n 
1 523 ASP n 
1 524 ILE n 
1 525 ILE n 
1 526 THR n 
1 527 ILE n 
1 528 ASP n 
1 529 ILE n 
1 530 GLY n 
1 531 ALA n 
1 532 ALA n 
1 533 ARG n 
1 534 ILE n 
1 535 ASP n 
1 536 THR n 
1 537 GLN n 
1 538 VAL n 
1 539 SER n 
1 540 PRO n 
1 541 GLU n 
1 542 GLU n 
1 543 MET n 
1 544 ASN n 
1 545 ASP n 
1 546 ARG n 
1 547 ARG n 
1 548 LYS n 
1 549 LYS n 
1 550 TRP n 
1 551 THR n 
1 552 ALA n 
1 553 PRO n 
1 554 ALA n 
1 555 TYR n 
1 556 LYS n 
1 557 VAL n 
1 558 ASN n 
1 559 ARG n 
1 560 GLY n 
1 561 VAL n 
1 562 LEU n 
1 563 TYR n 
1 564 LYS n 
1 565 TYR n 
1 566 ILE n 
1 567 LYS n 
1 568 ASN n 
1 569 VAL n 
1 570 GLN n 
1 571 SER n 
1 572 ALA n 
1 573 SER n 
1 574 ASP n 
1 575 GLY n 
1 576 CYS n 
1 577 VAL n 
1 578 THR n 
1 579 ASP n 
1 580 GLU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   580 
_entity_src_gen.gene_src_common_name               'thale cress' 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'DHAD, At3g23940, F14O13.13' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Arabidopsis thaliana' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     3702 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli K-12' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     83333 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                      ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                     ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                   ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'              ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE                     ? 'C3 H7 N O2 S'   121.158 
FES non-polymer         . 'FE2/S2 (INORGANIC) CLUSTER' ? 'Fe2 S2'         175.820 
GLN 'L-peptide linking' y GLUTAMINE                    ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'              ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                      ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                    ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                        ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE                   ? 'C6 H13 N O2'    131.173 
K0O non-polymer         . 'Aspterric Acid'             
'(1~{S},5~{S},8~{R},9~{R})-8-oxidanyl-4-propan-2-ylidene-10-oxatricyclo[7.2.1.0^{1,5}]dodecane-8-carboxylic acid' 'C15 H22 O4'     
266.333 
LEU 'L-peptide linking' y LEUCINE                      ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                       ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE                   ? 'C5 H11 N O2 S'  149.211 
MG  non-polymer         . 'MAGNESIUM ION'              ? 'Mg 2'           24.305  
PHE 'L-peptide linking' y PHENYLALANINE                ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE                      ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                       ? 'C3 H7 N O3'     105.093 
SO4 non-polymer         . 'SULFATE ION'                ? 'O4 S -2'        96.063  
THR 'L-peptide linking' y THREONINE                    ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                   ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                     ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                       ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   -5  ?   ?   ?   A . n 
A 1 2   SER 2   -4  ?   ?   ?   A . n 
A 1 3   ILE 3   -3  ?   ?   ?   A . n 
A 1 4   ILE 4   -2  ?   ?   ?   A . n 
A 1 5   SER 5   -1  ?   ?   ?   A . n 
A 1 6   CYS 6   0   ?   ?   ?   A . n 
A 1 7   SER 7   1   ?   ?   ?   A . n 
A 1 8   ALA 8   2   ?   ?   ?   A . n 
A 1 9   GLN 9   3   3   GLN GLN A . n 
A 1 10  SER 10  4   4   SER SER A . n 
A 1 11  VAL 11  5   5   VAL VAL A . n 
A 1 12  THR 12  6   6   THR THR A . n 
A 1 13  ALA 13  7   7   ALA ALA A . n 
A 1 14  ASP 14  8   8   ASP ASP A . n 
A 1 15  PRO 15  9   9   PRO PRO A . n 
A 1 16  SER 16  10  10  SER SER A . n 
A 1 17  PRO 17  11  11  PRO PRO A . n 
A 1 18  PRO 18  12  12  PRO PRO A . n 
A 1 19  ILE 19  13  ?   ?   ?   A . n 
A 1 20  THR 20  14  ?   ?   ?   A . n 
A 1 21  ASP 21  15  15  ASP ASP A . n 
A 1 22  THR 22  16  16  THR THR A . n 
A 1 23  ASN 23  17  17  ASN ASN A . n 
A 1 24  LYS 24  18  18  LYS LYS A . n 
A 1 25  LEU 25  19  19  LEU LEU A . n 
A 1 26  ASN 26  20  20  ASN ASN A . n 
A 1 27  LYS 27  21  21  LYS LYS A . n 
A 1 28  TYR 28  22  22  TYR TYR A . n 
A 1 29  SER 29  23  23  SER SER A . n 
A 1 30  SER 30  24  24  SER SER A . n 
A 1 31  ARG 31  25  25  ARG ARG A . n 
A 1 32  ILE 32  26  26  ILE ILE A . n 
A 1 33  THR 33  27  27  THR THR A . n 
A 1 34  GLU 34  28  28  GLU GLU A . n 
A 1 35  PRO 35  29  29  PRO PRO A . n 
A 1 36  LYS 36  30  30  LYS LYS A . n 
A 1 37  SER 37  31  31  SER SER A . n 
A 1 38  GLN 38  32  32  GLN GLN A . n 
A 1 39  GLY 39  33  33  GLY GLY A . n 
A 1 40  GLY 40  34  34  GLY GLY A . n 
A 1 41  SER 41  35  35  SER SER A . n 
A 1 42  GLN 42  36  36  GLN GLN A . n 
A 1 43  ALA 43  37  37  ALA ALA A . n 
A 1 44  ILE 44  38  38  ILE ILE A . n 
A 1 45  LEU 45  39  39  LEU LEU A . n 
A 1 46  HIS 46  40  40  HIS HIS A . n 
A 1 47  GLY 47  41  41  GLY GLY A . n 
A 1 48  VAL 48  42  42  VAL VAL A . n 
A 1 49  GLY 49  43  43  GLY GLY A . n 
A 1 50  LEU 50  44  44  LEU LEU A . n 
A 1 51  SER 51  45  45  SER SER A . n 
A 1 52  ASP 52  46  46  ASP ASP A . n 
A 1 53  ASP 53  47  47  ASP ASP A . n 
A 1 54  ASP 54  48  48  ASP ASP A . n 
A 1 55  LEU 55  49  49  LEU LEU A . n 
A 1 56  LEU 56  50  50  LEU LEU A . n 
A 1 57  LYS 57  51  51  LYS LYS A . n 
A 1 58  PRO 58  52  52  PRO PRO A . n 
A 1 59  GLN 59  53  53  GLN GLN A . n 
A 1 60  ILE 60  54  54  ILE ILE A . n 
A 1 61  GLY 61  55  55  GLY GLY A . n 
A 1 62  ILE 62  56  56  ILE ILE A . n 
A 1 63  SER 63  57  57  SER SER A . n 
A 1 64  SER 64  58  58  SER SER A . n 
A 1 65  VAL 65  59  59  VAL VAL A . n 
A 1 66  TRP 66  60  60  TRP TRP A . n 
A 1 67  TYR 67  61  61  TYR TYR A . n 
A 1 68  GLU 68  62  62  GLU GLU A . n 
A 1 69  GLY 69  63  63  GLY GLY A . n 
A 1 70  ASN 70  64  64  ASN ASN A . n 
A 1 71  THR 71  65  65  THR THR A . n 
A 1 72  CYS 72  66  66  CYS CYS A . n 
A 1 73  ASN 73  67  67  ASN ASN A . n 
A 1 74  MET 74  68  68  MET MET A . n 
A 1 75  HIS 75  69  69  HIS HIS A . n 
A 1 76  LEU 76  70  70  LEU LEU A . n 
A 1 77  LEU 77  71  71  LEU LEU A . n 
A 1 78  LYS 78  72  72  LYS LYS A . n 
A 1 79  LEU 79  73  73  LEU LEU A . n 
A 1 80  SER 80  74  74  SER SER A . n 
A 1 81  GLU 81  75  75  GLU GLU A . n 
A 1 82  ALA 82  76  76  ALA ALA A . n 
A 1 83  VAL 83  77  77  VAL VAL A . n 
A 1 84  LYS 84  78  78  LYS LYS A . n 
A 1 85  GLU 85  79  79  GLU GLU A . n 
A 1 86  GLY 86  80  80  GLY GLY A . n 
A 1 87  VAL 87  81  81  VAL VAL A . n 
A 1 88  GLU 88  82  82  GLU GLU A . n 
A 1 89  ASN 89  83  83  ASN ASN A . n 
A 1 90  ALA 90  84  84  ALA ALA A . n 
A 1 91  GLY 91  85  85  GLY GLY A . n 
A 1 92  MET 92  86  86  MET MET A . n 
A 1 93  VAL 93  87  87  VAL VAL A . n 
A 1 94  GLY 94  88  88  GLY GLY A . n 
A 1 95  PHE 95  89  89  PHE PHE A . n 
A 1 96  ARG 96  90  90  ARG ARG A . n 
A 1 97  PHE 97  91  91  PHE PHE A . n 
A 1 98  ASN 98  92  92  ASN ASN A . n 
A 1 99  THR 99  93  93  THR THR A . n 
A 1 100 ILE 100 94  94  ILE ILE A . n 
A 1 101 GLY 101 95  95  GLY GLY A . n 
A 1 102 VAL 102 96  96  VAL VAL A . n 
A 1 103 SER 103 97  97  SER SER A . n 
A 1 104 ASP 104 98  98  ASP ASP A . n 
A 1 105 ALA 105 99  99  ALA ALA A . n 
A 1 106 ILE 106 100 100 ILE ILE A . n 
A 1 107 SER 107 101 101 SER SER A . n 
A 1 108 MET 108 102 102 MET MET A . n 
A 1 109 GLY 109 103 103 GLY GLY A . n 
A 1 110 THR 110 104 104 THR THR A . n 
A 1 111 ARG 111 105 105 ARG ARG A . n 
A 1 112 GLY 112 106 106 GLY GLY A . n 
A 1 113 MET 113 107 107 MET MET A . n 
A 1 114 CYS 114 108 108 CYS CYS A . n 
A 1 115 PHE 115 109 109 PHE PHE A . n 
A 1 116 SER 116 110 110 SER SER A . n 
A 1 117 LEU 117 111 111 LEU LEU A . n 
A 1 118 GLN 118 112 112 GLN GLN A . n 
A 1 119 SER 119 113 113 SER SER A . n 
A 1 120 ARG 120 114 114 ARG ARG A . n 
A 1 121 ASP 121 115 115 ASP ASP A . n 
A 1 122 LEU 122 116 116 LEU LEU A . n 
A 1 123 ILE 123 117 117 ILE ILE A . n 
A 1 124 ALA 124 118 118 ALA ALA A . n 
A 1 125 ASP 125 119 119 ASP ASP A . n 
A 1 126 SER 126 120 120 SER SER A . n 
A 1 127 ILE 127 121 121 ILE ILE A . n 
A 1 128 GLU 128 122 122 GLU GLU A . n 
A 1 129 THR 129 123 123 THR THR A . n 
A 1 130 VAL 130 124 124 VAL VAL A . n 
A 1 131 MET 131 125 125 MET MET A . n 
A 1 132 SER 132 126 126 SER SER A . n 
A 1 133 ALA 133 127 127 ALA ALA A . n 
A 1 134 GLN 134 128 128 GLN GLN A . n 
A 1 135 TRP 135 129 129 TRP TRP A . n 
A 1 136 TYR 136 130 130 TYR TYR A . n 
A 1 137 ASP 137 131 131 ASP ASP A . n 
A 1 138 GLY 138 132 132 GLY GLY A . n 
A 1 139 ASN 139 133 133 ASN ASN A . n 
A 1 140 ILE 140 134 134 ILE ILE A . n 
A 1 141 SER 141 135 135 SER SER A . n 
A 1 142 ILE 142 136 136 ILE ILE A . n 
A 1 143 PRO 143 137 137 PRO PRO A . n 
A 1 144 GLY 144 138 138 GLY GLY A . n 
A 1 145 CYS 145 139 139 CYS CYS A . n 
A 1 146 ASP 146 140 140 ASP ASP A . n 
A 1 147 LYS 147 141 141 LYS LYS A . n 
A 1 148 ASN 148 142 142 ASN ASN A . n 
A 1 149 MET 149 143 143 MET MET A . n 
A 1 150 PRO 150 144 144 PRO PRO A . n 
A 1 151 GLY 151 145 145 GLY GLY A . n 
A 1 152 THR 152 146 146 THR THR A . n 
A 1 153 ILE 153 147 147 ILE ILE A . n 
A 1 154 MET 154 148 148 MET MET A . n 
A 1 155 ALA 155 149 149 ALA ALA A . n 
A 1 156 MET 156 150 150 MET MET A . n 
A 1 157 GLY 157 151 151 GLY GLY A . n 
A 1 158 ARG 158 152 152 ARG ARG A . n 
A 1 159 LEU 159 153 153 LEU LEU A . n 
A 1 160 ASN 160 154 154 ASN ASN A . n 
A 1 161 ARG 161 155 155 ARG ARG A . n 
A 1 162 PRO 162 156 156 PRO PRO A . n 
A 1 163 GLY 163 157 157 GLY GLY A . n 
A 1 164 ILE 164 158 158 ILE ILE A . n 
A 1 165 MET 165 159 159 MET MET A . n 
A 1 166 VAL 166 160 160 VAL VAL A . n 
A 1 167 TYR 167 161 161 TYR TYR A . n 
A 1 168 GLY 168 162 162 GLY GLY A . n 
A 1 169 GLY 169 163 163 GLY GLY A . n 
A 1 170 THR 170 164 164 THR THR A . n 
A 1 171 ILE 171 165 165 ILE ILE A . n 
A 1 172 LYS 172 166 166 LYS LYS A . n 
A 1 173 PRO 173 167 167 PRO PRO A . n 
A 1 174 GLY 174 168 168 GLY GLY A . n 
A 1 175 HIS 175 169 169 HIS HIS A . n 
A 1 176 PHE 176 170 170 PHE PHE A . n 
A 1 177 GLN 177 171 171 GLN GLN A . n 
A 1 178 ASP 178 172 172 ASP ASP A . n 
A 1 179 LYS 179 173 173 LYS LYS A . n 
A 1 180 THR 180 174 174 THR THR A . n 
A 1 181 TYR 181 175 175 TYR TYR A . n 
A 1 182 ASP 182 176 176 ASP ASP A . n 
A 1 183 ILE 183 177 177 ILE ILE A . n 
A 1 184 VAL 184 178 178 VAL VAL A . n 
A 1 185 SER 185 179 179 SER SER A . n 
A 1 186 ALA 186 180 180 ALA ALA A . n 
A 1 187 PHE 187 181 181 PHE PHE A . n 
A 1 188 GLN 188 182 182 GLN GLN A . n 
A 1 189 SER 189 183 183 SER SER A . n 
A 1 190 TYR 190 184 184 TYR TYR A . n 
A 1 191 GLY 191 185 185 GLY GLY A . n 
A 1 192 GLU 192 186 186 GLU GLU A . n 
A 1 193 PHE 193 187 187 PHE PHE A . n 
A 1 194 VAL 194 188 188 VAL VAL A . n 
A 1 195 SER 195 189 189 SER SER A . n 
A 1 196 GLY 196 190 190 GLY GLY A . n 
A 1 197 SER 197 191 191 SER SER A . n 
A 1 198 ILE 198 192 192 ILE ILE A . n 
A 1 199 SER 199 193 193 SER SER A . n 
A 1 200 ASP 200 194 194 ASP ASP A . n 
A 1 201 GLU 201 195 195 GLU GLU A . n 
A 1 202 GLN 202 196 196 GLN GLN A . n 
A 1 203 ARG 203 197 197 ARG ARG A . n 
A 1 204 LYS 204 198 198 LYS LYS A . n 
A 1 205 THR 205 199 199 THR THR A . n 
A 1 206 VAL 206 200 200 VAL VAL A . n 
A 1 207 LEU 207 201 201 LEU LEU A . n 
A 1 208 HIS 208 202 202 HIS HIS A . n 
A 1 209 HIS 209 203 203 HIS HIS A . n 
A 1 210 SER 210 204 204 SER SER A . n 
A 1 211 CYS 211 205 205 CYS CYS A . n 
A 1 212 PRO 212 206 206 PRO PRO A . n 
A 1 213 GLY 213 207 207 GLY GLY A . n 
A 1 214 ALA 214 208 208 ALA ALA A . n 
A 1 215 GLY 215 209 209 GLY GLY A . n 
A 1 216 ALA 216 210 210 ALA ALA A . n 
A 1 217 CYS 217 211 211 CYS CYS A . n 
A 1 218 GLY 218 212 212 GLY GLY A . n 
A 1 219 GLY 219 213 213 GLY GLY A . n 
A 1 220 MET 220 214 214 MET MET A . n 
A 1 221 TYR 221 215 215 TYR TYR A . n 
A 1 222 THR 222 216 216 THR THR A . n 
A 1 223 ALA 223 217 217 ALA ALA A . n 
A 1 224 ASN 224 218 218 ASN ASN A . n 
A 1 225 THR 225 219 219 THR THR A . n 
A 1 226 MET 226 220 220 MET MET A . n 
A 1 227 ALA 227 221 221 ALA ALA A . n 
A 1 228 SER 228 222 222 SER SER A . n 
A 1 229 ALA 229 223 223 ALA ALA A . n 
A 1 230 ILE 230 224 224 ILE ILE A . n 
A 1 231 GLU 231 225 225 GLU GLU A . n 
A 1 232 ALA 232 226 226 ALA ALA A . n 
A 1 233 MET 233 227 227 MET MET A . n 
A 1 234 GLY 234 228 228 GLY GLY A . n 
A 1 235 MET 235 229 229 MET MET A . n 
A 1 236 SER 236 230 230 SER SER A . n 
A 1 237 LEU 237 231 231 LEU LEU A . n 
A 1 238 PRO 238 232 232 PRO PRO A . n 
A 1 239 TYR 239 233 233 TYR TYR A . n 
A 1 240 SER 240 234 234 SER SER A . n 
A 1 241 SER 241 235 235 SER SER A . n 
A 1 242 SER 242 236 236 SER SER A . n 
A 1 243 ILE 243 237 237 ILE ILE A . n 
A 1 244 PRO 244 238 238 PRO PRO A . n 
A 1 245 ALA 245 239 239 ALA ALA A . n 
A 1 246 GLU 246 240 240 GLU GLU A . n 
A 1 247 ASP 247 241 241 ASP ASP A . n 
A 1 248 PRO 248 242 242 PRO PRO A . n 
A 1 249 LEU 249 243 243 LEU LEU A . n 
A 1 250 LYS 250 244 244 LYS LYS A . n 
A 1 251 LEU 251 245 245 LEU LEU A . n 
A 1 252 ASP 252 246 246 ASP ASP A . n 
A 1 253 GLU 253 247 247 GLU GLU A . n 
A 1 254 CYS 254 248 248 CYS CYS A . n 
A 1 255 ARG 255 249 249 ARG ARG A . n 
A 1 256 LEU 256 250 250 LEU LEU A . n 
A 1 257 ALA 257 251 251 ALA ALA A . n 
A 1 258 GLY 258 252 252 GLY GLY A . n 
A 1 259 LYS 259 253 253 LYS LYS A . n 
A 1 260 TYR 260 254 254 TYR TYR A . n 
A 1 261 LEU 261 255 255 LEU LEU A . n 
A 1 262 LEU 262 256 256 LEU LEU A . n 
A 1 263 GLU 263 257 257 GLU GLU A . n 
A 1 264 LEU 264 258 258 LEU LEU A . n 
A 1 265 LEU 265 259 259 LEU LEU A . n 
A 1 266 LYS 266 260 260 LYS LYS A . n 
A 1 267 MET 267 261 261 MET MET A . n 
A 1 268 ASP 268 262 262 ASP ASP A . n 
A 1 269 LEU 269 263 263 LEU LEU A . n 
A 1 270 LYS 270 264 264 LYS LYS A . n 
A 1 271 PRO 271 265 265 PRO PRO A . n 
A 1 272 ARG 272 266 266 ARG ARG A . n 
A 1 273 ASP 273 267 267 ASP ASP A . n 
A 1 274 ILE 274 268 268 ILE ILE A . n 
A 1 275 ILE 275 269 269 ILE ILE A . n 
A 1 276 THR 276 270 270 THR THR A . n 
A 1 277 PRO 277 271 271 PRO PRO A . n 
A 1 278 LYS 278 272 272 LYS LYS A . n 
A 1 279 SER 279 273 273 SER SER A . n 
A 1 280 LEU 280 274 274 LEU LEU A . n 
A 1 281 ARG 281 275 275 ARG ARG A . n 
A 1 282 ASN 282 276 276 ASN ASN A . n 
A 1 283 ALA 283 277 277 ALA ALA A . n 
A 1 284 MET 284 278 278 MET MET A . n 
A 1 285 VAL 285 279 279 VAL VAL A . n 
A 1 286 SER 286 280 280 SER SER A . n 
A 1 287 VAL 287 281 281 VAL VAL A . n 
A 1 288 MET 288 282 282 MET MET A . n 
A 1 289 ALA 289 283 283 ALA ALA A . n 
A 1 290 LEU 290 284 284 LEU LEU A . n 
A 1 291 GLY 291 285 285 GLY GLY A . n 
A 1 292 GLY 292 286 286 GLY GLY A . n 
A 1 293 SER 293 287 287 SER SER A . n 
A 1 294 THR 294 288 288 THR THR A . n 
A 1 295 ASN 295 289 289 ASN ASN A . n 
A 1 296 ALA 296 290 290 ALA ALA A . n 
A 1 297 VAL 297 291 291 VAL VAL A . n 
A 1 298 LEU 298 292 292 LEU LEU A . n 
A 1 299 HIS 299 293 293 HIS HIS A . n 
A 1 300 LEU 300 294 294 LEU LEU A . n 
A 1 301 ILE 301 295 295 ILE ILE A . n 
A 1 302 ALA 302 296 296 ALA ALA A . n 
A 1 303 ILE 303 297 297 ILE ILE A . n 
A 1 304 ALA 304 298 298 ALA ALA A . n 
A 1 305 ARG 305 299 299 ARG ARG A . n 
A 1 306 SER 306 300 300 SER SER A . n 
A 1 307 VAL 307 301 301 VAL VAL A . n 
A 1 308 GLY 308 302 302 GLY GLY A . n 
A 1 309 LEU 309 303 303 LEU LEU A . n 
A 1 310 GLU 310 304 304 GLU GLU A . n 
A 1 311 LEU 311 305 305 LEU LEU A . n 
A 1 312 THR 312 306 306 THR THR A . n 
A 1 313 LEU 313 307 307 LEU LEU A . n 
A 1 314 ASP 314 308 308 ASP ASP A . n 
A 1 315 ASP 315 309 309 ASP ASP A . n 
A 1 316 PHE 316 310 310 PHE PHE A . n 
A 1 317 GLN 317 311 311 GLN GLN A . n 
A 1 318 LYS 318 312 312 LYS LYS A . n 
A 1 319 VAL 319 313 313 VAL VAL A . n 
A 1 320 SER 320 314 314 SER SER A . n 
A 1 321 ASP 321 315 315 ASP ASP A . n 
A 1 322 ALA 322 316 316 ALA ALA A . n 
A 1 323 VAL 323 317 317 VAL VAL A . n 
A 1 324 PRO 324 318 318 PRO PRO A . n 
A 1 325 PHE 325 319 319 PHE PHE A . n 
A 1 326 LEU 326 320 320 LEU LEU A . n 
A 1 327 ALA 327 321 321 ALA ALA A . n 
A 1 328 ASP 328 322 322 ASP ASP A . n 
A 1 329 LEU 329 323 323 LEU LEU A . n 
A 1 330 LYS 330 324 324 LYS LYS A . n 
A 1 331 PRO 331 325 325 PRO PRO A . n 
A 1 332 SER 332 326 326 SER SER A . n 
A 1 333 GLY 333 327 327 GLY GLY A . n 
A 1 334 LYS 334 328 328 LYS LYS A . n 
A 1 335 TYR 335 329 329 TYR TYR A . n 
A 1 336 VAL 336 330 330 VAL VAL A . n 
A 1 337 MET 337 331 331 MET MET A . n 
A 1 338 GLU 338 332 332 GLU GLU A . n 
A 1 339 ASP 339 333 333 ASP ASP A . n 
A 1 340 ILE 340 334 334 ILE ILE A . n 
A 1 341 HIS 341 335 335 HIS HIS A . n 
A 1 342 LYS 342 336 336 LYS LYS A . n 
A 1 343 ILE 343 337 337 ILE ILE A . n 
A 1 344 GLY 344 338 338 GLY GLY A . n 
A 1 345 GLY 345 339 339 GLY GLY A . n 
A 1 346 THR 346 340 340 THR THR A . n 
A 1 347 PRO 347 341 341 PRO PRO A . n 
A 1 348 ALA 348 342 342 ALA ALA A . n 
A 1 349 VAL 349 343 343 VAL VAL A . n 
A 1 350 LEU 350 344 344 LEU LEU A . n 
A 1 351 ARG 351 345 345 ARG ARG A . n 
A 1 352 TYR 352 346 346 TYR TYR A . n 
A 1 353 LEU 353 347 347 LEU LEU A . n 
A 1 354 LEU 354 348 348 LEU LEU A . n 
A 1 355 GLU 355 349 349 GLU GLU A . n 
A 1 356 LEU 356 350 350 LEU LEU A . n 
A 1 357 GLY 357 351 351 GLY GLY A . n 
A 1 358 LEU 358 352 352 LEU LEU A . n 
A 1 359 MET 359 353 353 MET MET A . n 
A 1 360 ASP 360 354 354 ASP ASP A . n 
A 1 361 GLY 361 355 355 GLY GLY A . n 
A 1 362 ASP 362 356 356 ASP ASP A . n 
A 1 363 CYS 363 357 357 CYS CYS A . n 
A 1 364 MET 364 358 358 MET MET A . n 
A 1 365 THR 365 359 359 THR THR A . n 
A 1 366 VAL 366 360 360 VAL VAL A . n 
A 1 367 THR 367 361 361 THR THR A . n 
A 1 368 GLY 368 362 362 GLY GLY A . n 
A 1 369 GLN 369 363 363 GLN GLN A . n 
A 1 370 THR 370 364 364 THR THR A . n 
A 1 371 LEU 371 365 365 LEU LEU A . n 
A 1 372 ALA 372 366 366 ALA ALA A . n 
A 1 373 GLN 373 367 367 GLN GLN A . n 
A 1 374 ASN 374 368 368 ASN ASN A . n 
A 1 375 LEU 375 369 369 LEU LEU A . n 
A 1 376 GLU 376 370 370 GLU GLU A . n 
A 1 377 ASN 377 371 371 ASN ASN A . n 
A 1 378 VAL 378 372 372 VAL VAL A . n 
A 1 379 PRO 379 373 373 PRO PRO A . n 
A 1 380 SER 380 374 374 SER SER A . n 
A 1 381 LEU 381 375 375 LEU LEU A . n 
A 1 382 THR 382 376 376 THR THR A . n 
A 1 383 GLU 383 377 377 GLU GLU A . n 
A 1 384 GLY 384 378 378 GLY GLY A . n 
A 1 385 GLN 385 379 379 GLN GLN A . n 
A 1 386 GLU 386 380 380 GLU GLU A . n 
A 1 387 ILE 387 381 381 ILE ILE A . n 
A 1 388 ILE 388 382 382 ILE ILE A . n 
A 1 389 ARG 389 383 383 ARG ARG A . n 
A 1 390 PRO 390 384 384 PRO PRO A . n 
A 1 391 LEU 391 385 385 LEU LEU A . n 
A 1 392 SER 392 386 386 SER SER A . n 
A 1 393 ASN 393 387 387 ASN ASN A . n 
A 1 394 PRO 394 388 388 PRO PRO A . n 
A 1 395 ILE 395 389 389 ILE ILE A . n 
A 1 396 LYS 396 390 390 LYS LYS A . n 
A 1 397 GLU 397 391 391 GLU GLU A . n 
A 1 398 THR 398 392 392 THR THR A . n 
A 1 399 GLY 399 393 393 GLY GLY A . n 
A 1 400 HIS 400 394 394 HIS HIS A . n 
A 1 401 ILE 401 395 395 ILE ILE A . n 
A 1 402 GLN 402 396 396 GLN GLN A . n 
A 1 403 ILE 403 397 397 ILE ILE A . n 
A 1 404 LEU 404 398 398 LEU LEU A . n 
A 1 405 ARG 405 399 399 ARG ARG A . n 
A 1 406 GLY 406 400 400 GLY GLY A . n 
A 1 407 ASP 407 401 401 ASP ASP A . n 
A 1 408 LEU 408 402 402 LEU LEU A . n 
A 1 409 ALA 409 403 403 ALA ALA A . n 
A 1 410 PRO 410 404 404 PRO PRO A . n 
A 1 411 ASP 411 405 405 ASP ASP A . n 
A 1 412 GLY 412 406 406 GLY GLY A . n 
A 1 413 SER 413 407 407 SER SER A . n 
A 1 414 VAL 414 408 408 VAL VAL A . n 
A 1 415 ALA 415 409 409 ALA ALA A . n 
A 1 416 LYS 416 410 410 LYS LYS A . n 
A 1 417 ILE 417 411 411 ILE ILE A . n 
A 1 418 THR 418 412 412 THR THR A . n 
A 1 419 GLY 419 413 413 GLY GLY A . n 
A 1 420 LYS 420 414 414 LYS LYS A . n 
A 1 421 GLU 421 415 415 GLU GLU A . n 
A 1 422 GLY 422 416 416 GLY GLY A . n 
A 1 423 LEU 423 417 417 LEU LEU A . n 
A 1 424 TYR 424 418 418 TYR TYR A . n 
A 1 425 PHE 425 419 419 PHE PHE A . n 
A 1 426 SER 426 420 420 SER SER A . n 
A 1 427 GLY 427 421 421 GLY GLY A . n 
A 1 428 PRO 428 422 422 PRO PRO A . n 
A 1 429 ALA 429 423 423 ALA ALA A . n 
A 1 430 LEU 430 424 424 LEU LEU A . n 
A 1 431 VAL 431 425 425 VAL VAL A . n 
A 1 432 PHE 432 426 426 PHE PHE A . n 
A 1 433 GLU 433 427 427 GLU GLU A . n 
A 1 434 GLY 434 428 428 GLY GLY A . n 
A 1 435 GLU 435 429 429 GLU GLU A . n 
A 1 436 GLU 436 430 430 GLU GLU A . n 
A 1 437 SER 437 431 431 SER SER A . n 
A 1 438 MET 438 432 432 MET MET A . n 
A 1 439 LEU 439 433 433 LEU LEU A . n 
A 1 440 ALA 440 434 434 ALA ALA A . n 
A 1 441 ALA 441 435 435 ALA ALA A . n 
A 1 442 ILE 442 436 436 ILE ILE A . n 
A 1 443 SER 443 437 437 SER SER A . n 
A 1 444 ALA 444 438 438 ALA ALA A . n 
A 1 445 ASP 445 439 439 ASP ASP A . n 
A 1 446 PRO 446 440 440 PRO PRO A . n 
A 1 447 MET 447 441 441 MET MET A . n 
A 1 448 SER 448 442 442 SER SER A . n 
A 1 449 PHE 449 443 443 PHE PHE A . n 
A 1 450 LYS 450 444 444 LYS LYS A . n 
A 1 451 GLY 451 445 445 GLY GLY A . n 
A 1 452 THR 452 446 446 THR THR A . n 
A 1 453 VAL 453 447 447 VAL VAL A . n 
A 1 454 VAL 454 448 448 VAL VAL A . n 
A 1 455 VAL 455 449 449 VAL VAL A . n 
A 1 456 ILE 456 450 450 ILE ILE A . n 
A 1 457 ARG 457 451 451 ARG ARG A . n 
A 1 458 GLY 458 452 452 GLY GLY A . n 
A 1 459 GLU 459 453 453 GLU GLU A . n 
A 1 460 GLY 460 454 454 GLY GLY A . n 
A 1 461 PRO 461 455 455 PRO PRO A . n 
A 1 462 LYS 462 456 456 LYS LYS A . n 
A 1 463 GLY 463 457 457 GLY GLY A . n 
A 1 464 GLY 464 458 458 GLY GLY A . n 
A 1 465 PRO 465 459 459 PRO PRO A . n 
A 1 466 GLY 466 460 460 GLY GLY A . n 
A 1 467 MET 467 461 461 MET MET A . n 
A 1 468 PRO 468 462 462 PRO PRO A . n 
A 1 469 GLU 469 463 463 GLU GLU A . n 
A 1 470 MET 470 464 464 MET MET A . n 
A 1 471 LEU 471 465 465 LEU LEU A . n 
A 1 472 THR 472 466 466 THR THR A . n 
A 1 473 PRO 473 467 467 PRO PRO A . n 
A 1 474 THR 474 468 468 THR THR A . n 
A 1 475 SER 475 469 469 SER SER A . n 
A 1 476 ALA 476 470 470 ALA ALA A . n 
A 1 477 ILE 477 471 471 ILE ILE A . n 
A 1 478 MET 478 472 472 MET MET A . n 
A 1 479 GLY 479 473 473 GLY GLY A . n 
A 1 480 ALA 480 474 474 ALA ALA A . n 
A 1 481 GLY 481 475 475 GLY GLY A . n 
A 1 482 LEU 482 476 476 LEU LEU A . n 
A 1 483 GLY 483 477 477 GLY GLY A . n 
A 1 484 LYS 484 478 478 LYS LYS A . n 
A 1 485 GLU 485 479 479 GLU GLU A . n 
A 1 486 CYS 486 480 480 CYS CYS A . n 
A 1 487 ALA 487 481 481 ALA ALA A . n 
A 1 488 LEU 488 482 482 LEU LEU A . n 
A 1 489 LEU 489 483 483 LEU LEU A . n 
A 1 490 THR 490 484 484 THR THR A . n 
A 1 491 ASP 491 485 485 ASP ASP A . n 
A 1 492 GLY 492 486 486 GLY GLY A . n 
A 1 493 ARG 493 487 487 ARG ARG A . n 
A 1 494 PHE 494 488 488 PHE PHE A . n 
A 1 495 SER 495 489 489 SER SER A . n 
A 1 496 GLY 496 490 490 GLY GLY A . n 
A 1 497 GLY 497 491 491 GLY GLY A . n 
A 1 498 SER 498 492 492 SER SER A . n 
A 1 499 HIS 499 493 493 HIS HIS A . n 
A 1 500 GLY 500 494 494 GLY GLY A . n 
A 1 501 PHE 501 495 495 PHE PHE A . n 
A 1 502 VAL 502 496 496 VAL VAL A . n 
A 1 503 VAL 503 497 497 VAL VAL A . n 
A 1 504 GLY 504 498 498 GLY GLY A . n 
A 1 505 HIS 505 499 499 HIS HIS A . n 
A 1 506 ILE 506 500 500 ILE ILE A . n 
A 1 507 CYS 507 501 501 CYS CYS A . n 
A 1 508 PRO 508 502 502 PRO PRO A . n 
A 1 509 GLU 509 503 503 GLU GLU A . n 
A 1 510 ALA 510 504 504 ALA ALA A . n 
A 1 511 GLN 511 505 505 GLN GLN A . n 
A 1 512 GLU 512 506 506 GLU GLU A . n 
A 1 513 GLY 513 507 507 GLY GLY A . n 
A 1 514 GLY 514 508 508 GLY GLY A . n 
A 1 515 PRO 515 509 509 PRO PRO A . n 
A 1 516 ILE 516 510 510 ILE ILE A . n 
A 1 517 GLY 517 511 511 GLY GLY A . n 
A 1 518 LEU 518 512 512 LEU LEU A . n 
A 1 519 ILE 519 513 513 ILE ILE A . n 
A 1 520 LYS 520 514 514 LYS LYS A . n 
A 1 521 ASN 521 515 515 ASN ASN A . n 
A 1 522 GLY 522 516 516 GLY GLY A . n 
A 1 523 ASP 523 517 517 ASP ASP A . n 
A 1 524 ILE 524 518 518 ILE ILE A . n 
A 1 525 ILE 525 519 519 ILE ILE A . n 
A 1 526 THR 526 520 520 THR THR A . n 
A 1 527 ILE 527 521 521 ILE ILE A . n 
A 1 528 ASP 528 522 522 ASP ASP A . n 
A 1 529 ILE 529 523 523 ILE ILE A . n 
A 1 530 GLY 530 524 524 GLY GLY A . n 
A 1 531 ALA 531 525 525 ALA ALA A . n 
A 1 532 ALA 532 526 526 ALA ALA A . n 
A 1 533 ARG 533 527 527 ARG ARG A . n 
A 1 534 ILE 534 528 528 ILE ILE A . n 
A 1 535 ASP 535 529 529 ASP ASP A . n 
A 1 536 THR 536 530 530 THR THR A . n 
A 1 537 GLN 537 531 531 GLN GLN A . n 
A 1 538 VAL 538 532 532 VAL VAL A . n 
A 1 539 SER 539 533 533 SER SER A . n 
A 1 540 PRO 540 534 534 PRO PRO A . n 
A 1 541 GLU 541 535 535 GLU GLU A . n 
A 1 542 GLU 542 536 536 GLU GLU A . n 
A 1 543 MET 543 537 537 MET MET A . n 
A 1 544 ASN 544 538 538 ASN ASN A . n 
A 1 545 ASP 545 539 539 ASP ASP A . n 
A 1 546 ARG 546 540 540 ARG ARG A . n 
A 1 547 ARG 547 541 541 ARG ARG A . n 
A 1 548 LYS 548 542 542 LYS LYS A . n 
A 1 549 LYS 549 543 543 LYS LYS A . n 
A 1 550 TRP 550 544 544 TRP TRP A . n 
A 1 551 THR 551 545 545 THR THR A . n 
A 1 552 ALA 552 546 546 ALA ALA A . n 
A 1 553 PRO 553 547 547 PRO PRO A . n 
A 1 554 ALA 554 548 548 ALA ALA A . n 
A 1 555 TYR 555 549 549 TYR TYR A . n 
A 1 556 LYS 556 550 550 LYS LYS A . n 
A 1 557 VAL 557 551 551 VAL VAL A . n 
A 1 558 ASN 558 552 552 ASN ASN A . n 
A 1 559 ARG 559 553 553 ARG ARG A . n 
A 1 560 GLY 560 554 554 GLY GLY A . n 
A 1 561 VAL 561 555 555 VAL VAL A . n 
A 1 562 LEU 562 556 556 LEU LEU A . n 
A 1 563 TYR 563 557 557 TYR TYR A . n 
A 1 564 LYS 564 558 558 LYS LYS A . n 
A 1 565 TYR 565 559 559 TYR TYR A . n 
A 1 566 ILE 566 560 560 ILE ILE A . n 
A 1 567 LYS 567 561 561 LYS LYS A . n 
A 1 568 ASN 568 562 562 ASN ASN A . n 
A 1 569 VAL 569 563 563 VAL VAL A . n 
A 1 570 GLN 570 564 564 GLN GLN A . n 
A 1 571 SER 571 565 565 SER SER A . n 
A 1 572 ALA 572 566 566 ALA ALA A . n 
A 1 573 SER 573 567 567 SER SER A . n 
A 1 574 ASP 574 568 568 ASP ASP A . n 
A 1 575 GLY 575 569 569 GLY GLY A . n 
A 1 576 CYS 576 570 570 CYS CYS A . n 
A 1 577 VAL 577 571 571 VAL VAL A . n 
A 1 578 THR 578 572 572 THR THR A . n 
A 1 579 ASP 579 573 573 ASP ASP A . n 
A 1 580 GLU 580 574 574 GLU GLU A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        K0O 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   K0O 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 MG  1   601 601 MG  MG  A . 
C 3 SO4 1   602 602 SO4 SO4 A . 
D 4 K0O 1   603 603 K0O K0O A . 
E 4 K0O 1   604 604 K0O K0O A . 
F 5 FES 1   605 605 FES FES A . 
G 6 HOH 1   701 701 HOH HOH A . 
G 6 HOH 2   702 702 HOH HOH A . 
G 6 HOH 3   703 703 HOH HOH A . 
G 6 HOH 4   704 704 HOH HOH A . 
G 6 HOH 5   705 705 HOH HOH A . 
G 6 HOH 6   706 706 HOH HOH A . 
G 6 HOH 7   707 707 HOH HOH A . 
G 6 HOH 8   708 708 HOH HOH A . 
G 6 HOH 9   709 709 HOH HOH A . 
G 6 HOH 10  710 710 HOH HOH A . 
G 6 HOH 11  711 711 HOH HOH A . 
G 6 HOH 12  712 712 HOH HOH A . 
G 6 HOH 13  713 713 HOH HOH A . 
G 6 HOH 14  714 714 HOH HOH A . 
G 6 HOH 15  715 715 HOH HOH A . 
G 6 HOH 16  716 716 HOH HOH A . 
G 6 HOH 17  717 717 HOH HOH A . 
G 6 HOH 18  718 718 HOH HOH A . 
G 6 HOH 19  719 719 HOH HOH A . 
G 6 HOH 20  720 720 HOH HOH A . 
G 6 HOH 21  721 721 HOH HOH A . 
G 6 HOH 22  722 722 HOH HOH A . 
G 6 HOH 23  723 723 HOH HOH A . 
G 6 HOH 24  724 724 HOH HOH A . 
G 6 HOH 25  725 725 HOH HOH A . 
G 6 HOH 26  726 726 HOH HOH A . 
G 6 HOH 27  727 727 HOH HOH A . 
G 6 HOH 28  728 728 HOH HOH A . 
G 6 HOH 29  729 729 HOH HOH A . 
G 6 HOH 30  730 730 HOH HOH A . 
G 6 HOH 31  731 731 HOH HOH A . 
G 6 HOH 32  732 732 HOH HOH A . 
G 6 HOH 33  733 733 HOH HOH A . 
G 6 HOH 34  734 734 HOH HOH A . 
G 6 HOH 35  735 735 HOH HOH A . 
G 6 HOH 36  736 736 HOH HOH A . 
G 6 HOH 37  737 737 HOH HOH A . 
G 6 HOH 38  738 738 HOH HOH A . 
G 6 HOH 39  739 739 HOH HOH A . 
G 6 HOH 40  740 740 HOH HOH A . 
G 6 HOH 41  741 741 HOH HOH A . 
G 6 HOH 42  742 742 HOH HOH A . 
G 6 HOH 43  743 743 HOH HOH A . 
G 6 HOH 44  744 744 HOH HOH A . 
G 6 HOH 45  745 745 HOH HOH A . 
G 6 HOH 46  746 746 HOH HOH A . 
G 6 HOH 47  747 747 HOH HOH A . 
G 6 HOH 48  748 748 HOH HOH A . 
G 6 HOH 49  749 749 HOH HOH A . 
G 6 HOH 50  750 750 HOH HOH A . 
G 6 HOH 51  751 751 HOH HOH A . 
G 6 HOH 52  752 752 HOH HOH A . 
G 6 HOH 53  753 753 HOH HOH A . 
G 6 HOH 54  754 754 HOH HOH A . 
G 6 HOH 55  755 755 HOH HOH A . 
G 6 HOH 56  756 756 HOH HOH A . 
G 6 HOH 57  757 757 HOH HOH A . 
G 6 HOH 58  758 758 HOH HOH A . 
G 6 HOH 59  759 759 HOH HOH A . 
G 6 HOH 60  760 760 HOH HOH A . 
G 6 HOH 61  761 761 HOH HOH A . 
G 6 HOH 62  762 762 HOH HOH A . 
G 6 HOH 63  763 763 HOH HOH A . 
G 6 HOH 64  764 764 HOH HOH A . 
G 6 HOH 65  765 765 HOH HOH A . 
G 6 HOH 66  766 766 HOH HOH A . 
G 6 HOH 67  767 767 HOH HOH A . 
G 6 HOH 68  768 768 HOH HOH A . 
G 6 HOH 69  769 769 HOH HOH A . 
G 6 HOH 70  770 770 HOH HOH A . 
G 6 HOH 71  771 771 HOH HOH A . 
G 6 HOH 72  772 772 HOH HOH A . 
G 6 HOH 73  773 773 HOH HOH A . 
G 6 HOH 74  774 774 HOH HOH A . 
G 6 HOH 75  775 775 HOH HOH A . 
G 6 HOH 76  776 776 HOH HOH A . 
G 6 HOH 77  777 777 HOH HOH A . 
G 6 HOH 78  778 778 HOH HOH A . 
G 6 HOH 79  779 779 HOH HOH A . 
G 6 HOH 80  780 780 HOH HOH A . 
G 6 HOH 81  781 781 HOH HOH A . 
G 6 HOH 82  782 782 HOH HOH A . 
G 6 HOH 83  783 783 HOH HOH A . 
G 6 HOH 84  784 784 HOH HOH A . 
G 6 HOH 85  785 785 HOH HOH A . 
G 6 HOH 86  786 786 HOH HOH A . 
G 6 HOH 87  787 787 HOH HOH A . 
G 6 HOH 88  788 788 HOH HOH A . 
G 6 HOH 89  789 789 HOH HOH A . 
G 6 HOH 90  790 790 HOH HOH A . 
G 6 HOH 91  791 791 HOH HOH A . 
G 6 HOH 92  792 792 HOH HOH A . 
G 6 HOH 93  793 793 HOH HOH A . 
G 6 HOH 94  794 794 HOH HOH A . 
G 6 HOH 95  795 795 HOH HOH A . 
G 6 HOH 96  796 796 HOH HOH A . 
G 6 HOH 97  797 797 HOH HOH A . 
G 6 HOH 98  798 798 HOH HOH A . 
G 6 HOH 99  799 799 HOH HOH A . 
G 6 HOH 100 800 800 HOH HOH A . 
G 6 HOH 101 801 801 HOH HOH A . 
G 6 HOH 102 802 802 HOH HOH A . 
G 6 HOH 103 803 803 HOH HOH A . 
G 6 HOH 104 804 804 HOH HOH A . 
G 6 HOH 105 805 805 HOH HOH A . 
G 6 HOH 106 806 806 HOH HOH A . 
G 6 HOH 107 807 807 HOH HOH A . 
G 6 HOH 108 808 808 HOH HOH A . 
G 6 HOH 109 809 809 HOH HOH A . 
G 6 HOH 110 810 810 HOH HOH A . 
G 6 HOH 111 811 811 HOH HOH A . 
G 6 HOH 112 812 812 HOH HOH A . 
G 6 HOH 113 813 813 HOH HOH A . 
G 6 HOH 114 814 814 HOH HOH A . 
G 6 HOH 115 815 815 HOH HOH A . 
G 6 HOH 116 816 816 HOH HOH A . 
G 6 HOH 117 817 817 HOH HOH A . 
G 6 HOH 118 818 818 HOH HOH A . 
G 6 HOH 119 819 819 HOH HOH A . 
G 6 HOH 120 820 820 HOH HOH A . 
G 6 HOH 121 821 821 HOH HOH A . 
G 6 HOH 122 822 822 HOH HOH A . 
G 6 HOH 123 823 823 HOH HOH A . 
G 6 HOH 124 824 824 HOH HOH A . 
G 6 HOH 125 825 825 HOH HOH A . 
G 6 HOH 126 826 826 HOH HOH A . 
G 6 HOH 127 827 827 HOH HOH A . 
G 6 HOH 128 828 828 HOH HOH A . 
G 6 HOH 129 829 829 HOH HOH A . 
G 6 HOH 130 830 830 HOH HOH A . 
G 6 HOH 131 831 831 HOH HOH A . 
G 6 HOH 132 832 832 HOH HOH A . 
G 6 HOH 133 833 833 HOH HOH A . 
G 6 HOH 134 834 834 HOH HOH A . 
G 6 HOH 135 835 835 HOH HOH A . 
G 6 HOH 136 836 836 HOH HOH A . 
G 6 HOH 137 837 837 HOH HOH A . 
G 6 HOH 138 838 838 HOH HOH A . 
G 6 HOH 139 839 839 HOH HOH A . 
G 6 HOH 140 840 840 HOH HOH A . 
G 6 HOH 141 841 841 HOH HOH A . 
G 6 HOH 142 842 842 HOH HOH A . 
G 6 HOH 143 843 843 HOH HOH A . 
G 6 HOH 144 844 844 HOH HOH A . 
G 6 HOH 145 845 845 HOH HOH A . 
G 6 HOH 146 846 846 HOH HOH A . 
G 6 HOH 147 847 847 HOH HOH A . 
G 6 HOH 148 848 848 HOH HOH A . 
G 6 HOH 149 849 849 HOH HOH A . 
G 6 HOH 150 850 850 HOH HOH A . 
G 6 HOH 151 851 851 HOH HOH A . 
G 6 HOH 152 852 852 HOH HOH A . 
G 6 HOH 153 853 853 HOH HOH A . 
G 6 HOH 154 854 854 HOH HOH A . 
G 6 HOH 155 855 855 HOH HOH A . 
G 6 HOH 156 856 856 HOH HOH A . 
G 6 HOH 157 857 857 HOH HOH A . 
G 6 HOH 158 858 858 HOH HOH A . 
G 6 HOH 159 859 859 HOH HOH A . 
G 6 HOH 160 860 860 HOH HOH A . 
G 6 HOH 161 861 861 HOH HOH A . 
G 6 HOH 162 862 862 HOH HOH A . 
G 6 HOH 163 863 863 HOH HOH A . 
G 6 HOH 164 864 864 HOH HOH A . 
G 6 HOH 165 865 865 HOH HOH A . 
G 6 HOH 166 866 866 HOH HOH A . 
G 6 HOH 167 867 867 HOH HOH A . 
G 6 HOH 168 868 868 HOH HOH A . 
G 6 HOH 169 869 869 HOH HOH A . 
G 6 HOH 170 870 870 HOH HOH A . 
G 6 HOH 171 871 871 HOH HOH A . 
G 6 HOH 172 872 872 HOH HOH A . 
G 6 HOH 173 873 873 HOH HOH A . 
G 6 HOH 174 874 874 HOH HOH A . 
G 6 HOH 175 875 875 HOH HOH A . 
G 6 HOH 176 876 876 HOH HOH A . 
G 6 HOH 177 877 877 HOH HOH A . 
G 6 HOH 178 878 878 HOH HOH A . 
G 6 HOH 179 879 879 HOH HOH A . 
G 6 HOH 180 880 880 HOH HOH A . 
G 6 HOH 181 881 881 HOH HOH A . 
G 6 HOH 182 882 882 HOH HOH A . 
G 6 HOH 183 883 883 HOH HOH A . 
G 6 HOH 184 884 884 HOH HOH A . 
G 6 HOH 185 885 885 HOH HOH A . 
G 6 HOH 186 886 886 HOH HOH A . 
G 6 HOH 187 887 887 HOH HOH A . 
G 6 HOH 188 888 888 HOH HOH A . 
G 6 HOH 189 889 889 HOH HOH A . 
G 6 HOH 190 890 890 HOH HOH A . 
G 6 HOH 191 891 891 HOH HOH A . 
G 6 HOH 192 892 892 HOH HOH A . 
G 6 HOH 193 893 893 HOH HOH A . 
G 6 HOH 194 894 894 HOH HOH A . 
G 6 HOH 195 895 895 HOH HOH A . 
G 6 HOH 196 896 896 HOH HOH A . 
G 6 HOH 197 897 897 HOH HOH A . 
G 6 HOH 198 898 898 HOH HOH A . 
G 6 HOH 199 899 899 HOH HOH A . 
G 6 HOH 200 900 900 HOH HOH A . 
G 6 HOH 201 901 901 HOH HOH A . 
G 6 HOH 202 902 902 HOH HOH A . 
G 6 HOH 203 903 903 HOH HOH A . 
G 6 HOH 204 904 904 HOH HOH A . 
G 6 HOH 205 905 905 HOH HOH A . 
G 6 HOH 206 906 906 HOH HOH A . 
G 6 HOH 207 907 907 HOH HOH A . 
G 6 HOH 208 908 908 HOH HOH A . 
G 6 HOH 209 909 909 HOH HOH A . 
G 6 HOH 210 910 910 HOH HOH A . 
G 6 HOH 211 911 911 HOH HOH A . 
G 6 HOH 212 912 912 HOH HOH A . 
G 6 HOH 213 913 913 HOH HOH A . 
G 6 HOH 214 914 914 HOH HOH A . 
G 6 HOH 215 915 915 HOH HOH A . 
G 6 HOH 216 916 916 HOH HOH A . 
G 6 HOH 217 917 917 HOH HOH A . 
G 6 HOH 218 918 918 HOH HOH A . 
G 6 HOH 219 919 919 HOH HOH A . 
G 6 HOH 220 920 920 HOH HOH A . 
G 6 HOH 221 921 921 HOH HOH A . 
G 6 HOH 222 922 922 HOH HOH A . 
G 6 HOH 223 923 923 HOH HOH A . 
G 6 HOH 224 924 924 HOH HOH A . 
G 6 HOH 225 925 925 HOH HOH A . 
G 6 HOH 226 926 926 HOH HOH A . 
G 6 HOH 227 927 927 HOH HOH A . 
G 6 HOH 228 928 928 HOH HOH A . 
G 6 HOH 229 929 929 HOH HOH A . 
G 6 HOH 230 930 930 HOH HOH A . 
G 6 HOH 231 931 931 HOH HOH A . 
G 6 HOH 232 932 932 HOH HOH A . 
G 6 HOH 233 933 933 HOH HOH A . 
G 6 HOH 234 934 934 HOH HOH A . 
G 6 HOH 235 935 935 HOH HOH A . 
G 6 HOH 236 936 936 HOH HOH A . 
G 6 HOH 237 937 937 HOH HOH A . 
G 6 HOH 238 938 938 HOH HOH A . 
G 6 HOH 239 939 939 HOH HOH A . 
G 6 HOH 240 940 940 HOH HOH A . 
G 6 HOH 241 941 941 HOH HOH A . 
G 6 HOH 242 942 942 HOH HOH A . 
G 6 HOH 243 943 943 HOH HOH A . 
G 6 HOH 244 944 944 HOH HOH A . 
G 6 HOH 245 945 945 HOH HOH A . 
G 6 HOH 246 946 946 HOH HOH A . 
G 6 HOH 247 947 947 HOH HOH A . 
G 6 HOH 248 948 948 HOH HOH A . 
G 6 HOH 249 949 949 HOH HOH A . 
G 6 HOH 250 950 950 HOH HOH A . 
G 6 HOH 251 951 951 HOH HOH A . 
G 6 HOH 252 952 952 HOH HOH A . 
G 6 HOH 253 953 953 HOH HOH A . 
G 6 HOH 254 954 954 HOH HOH A . 
G 6 HOH 255 955 955 HOH HOH A . 
G 6 HOH 256 956 956 HOH HOH A . 
G 6 HOH 257 957 957 HOH HOH A . 
G 6 HOH 258 958 958 HOH HOH A . 
G 6 HOH 259 959 959 HOH HOH A . 
G 6 HOH 260 960 960 HOH HOH A . 
G 6 HOH 261 961 961 HOH HOH A . 
G 6 HOH 262 962 962 HOH HOH A . 
G 6 HOH 263 963 963 HOH HOH A . 
G 6 HOH 264 964 964 HOH HOH A . 
G 6 HOH 265 965 965 HOH HOH A . 
G 6 HOH 266 966 966 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A ASP 15  ? CG  ? A ASP 21  CG  
2  1 Y 1 A ASP 15  ? OD1 ? A ASP 21  OD1 
3  1 Y 1 A ASP 15  ? OD2 ? A ASP 21  OD2 
4  1 Y 1 A GLU 377 ? CG  ? A GLU 383 CG  
5  1 Y 1 A GLU 377 ? CD  ? A GLU 383 CD  
6  1 Y 1 A GLU 377 ? OE1 ? A GLU 383 OE1 
7  1 Y 1 A GLU 377 ? OE2 ? A GLU 383 OE2 
8  1 Y 1 A HIS 493 ? CG  ? A HIS 499 CG  
9  1 Y 1 A HIS 493 ? ND1 ? A HIS 499 ND1 
10 1 Y 1 A HIS 493 ? CD2 ? A HIS 499 CD2 
11 1 Y 1 A HIS 493 ? CE1 ? A HIS 499 CE1 
12 1 Y 1 A HIS 493 ? NE2 ? A HIS 499 NE2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XSCALE ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9JPI 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     135.890 
_cell.length_a_esd                 ? 
_cell.length_b                     135.890 
_cell.length_b_esd                 ? 
_cell.length_c                     66.640 
_cell.length_c_esd                 ? 
_cell.volume                       1230580.378 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9JPI 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                94 
_symmetry.space_group_name_Hall            'P 4n 2n' 
_symmetry.space_group_name_H-M             'P 42 21 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9JPI 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.53 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          51.45 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              5.0 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
;0.1 M sodium acetate pH 5.0,
1.5 M ammonium sulfate
;
_exptl_crystal_grow.pdbx_pH_range   4.5-5.5 
_exptl_crystal_grow.temp            289 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 300K' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2018-03-16 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97852 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL19U1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97852 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL19U1 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          29.15 
_reflns.entry_id                                       9JPI 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.00 
_reflns.d_resolution_low                               47.58 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     42678 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100.0 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                7.2 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          8.6 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.995 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.145 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.00 
_reflns_shell.d_res_low                                     2.05 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             3089 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.725 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.007 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               35.48 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9JPI 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.00 
_refine.ls_d_res_low                             47.58 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     42627 
_refine.ls_number_reflns_R_free                  2101 
_refine.ls_number_reflns_R_work                  40526 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.92 
_refine.ls_percent_reflns_R_free                 4.93 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1833 
_refine.ls_R_factor_R_free                       0.2140 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1817 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      5ZE4 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 21.2243 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1968 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.00 
_refine_hist.d_res_low                        47.58 
_refine_hist.number_atoms_solvent             266 
_refine_hist.number_atoms_total               4541 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        4227 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         48 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0084  ? 4375 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.9478  ? 5934 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0511  ? 674  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0065  ? 768  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 14.4450 ? 1638 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.00 2.05  . . 127 2646 99.93  . . . . 0.2485 . . . . . . . . . . . 0.2915 
'X-RAY DIFFRACTION' 2.05 2.10  . . 138 2658 100.00 . . . . 0.2319 . . . . . . . . . . . 0.2776 
'X-RAY DIFFRACTION' 2.10 2.15  . . 110 2693 99.96  . . . . 0.2153 . . . . . . . . . . . 0.2260 
'X-RAY DIFFRACTION' 2.15 2.22  . . 137 2664 100.00 . . . . 0.2199 . . . . . . . . . . . 0.2441 
'X-RAY DIFFRACTION' 2.22 2.29  . . 126 2687 99.93  . . . . 0.2177 . . . . . . . . . . . 0.2653 
'X-RAY DIFFRACTION' 2.29 2.37  . . 141 2662 100.00 . . . . 0.2103 . . . . . . . . . . . 0.2592 
'X-RAY DIFFRACTION' 2.37 2.47  . . 176 2644 100.00 . . . . 0.1975 . . . . . . . . . . . 0.2461 
'X-RAY DIFFRACTION' 2.47 2.58  . . 148 2661 100.00 . . . . 0.1866 . . . . . . . . . . . 0.2263 
'X-RAY DIFFRACTION' 2.58 2.71  . . 138 2692 100.00 . . . . 0.1894 . . . . . . . . . . . 0.2161 
'X-RAY DIFFRACTION' 2.71 2.88  . . 135 2708 99.89  . . . . 0.1859 . . . . . . . . . . . 0.2201 
'X-RAY DIFFRACTION' 2.88 3.11  . . 133 2691 99.96  . . . . 0.1820 . . . . . . . . . . . 0.2409 
'X-RAY DIFFRACTION' 3.11 3.42  . . 153 2709 100.00 . . . . 0.1745 . . . . . . . . . . . 0.2174 
'X-RAY DIFFRACTION' 3.42 3.91  . . 156 2728 99.93  . . . . 0.1594 . . . . . . . . . . . 0.1879 
'X-RAY DIFFRACTION' 3.91 4.93  . . 146 2757 99.69  . . . . 0.1450 . . . . . . . . . . . 0.1564 
'X-RAY DIFFRACTION' 4.93 47.58 . . 137 2926 99.55  . . . . 0.1843 . . . . . . . . . . . 0.2141 
# 
_struct.entry_id                     9JPI 
_struct.title                        'The complex structure of DHAD with aspterric acid (AA).' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9JPI 
_struct_keywords.text            '[2Fe-2S] cluster, mutant, BCAA biosynthetic pathway, LYASE' 
_struct_keywords.pdbx_keywords   LYASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 4 ? 
F N N 5 ? 
G N N 6 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    ILVD_ARATH 
_struct_ref.pdbx_db_accession          Q9LIR4 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SIISCSAQSVTADPSPPITDTNKLNKYSSRITEPKSQGGSQAILHGVGLSDDDLLKPQIGISSVWYEGNTCNMHLLKLSE
AVKEGVENAGMVGFRFNTIGVSDAISMGTRGMCFSLQSRDLIADSIETVMSAQWYDGNISIPGCDKNMPGTIMAMGRLNR
PGIMVYGGTIKPGHFQDKTYDIVSAFQSYGEFVSGSISDEQRKTVLHHSCPGAGACGGMYTANTMASAIEAMGMSLPYSS
SIPAEDPLKLDECRLAGKYLLELLKMDLKPRDIITPKSLRNAMVSVMALGGSTNAVLHLIAIARSVGLELTLDDFQKVSD
AVPFLADLKPSGKYVMEDIHKIGGTPAVLRYLLELGLMDGDCMTVTGQTLAQNLENVPSLTEGQEIIRPLSNPIKETGHI
QILRGDLAPDGSVAKITGKEGLYFSGPALVFEGEESMLAAISADPMSFKGTVVVIRGEGPKGGPGMPEMLTPTSAIMGAG
LGKECALLTDGRFSGGSHGFVVGHICPEAQEGGPIGLIKNGDIITIDIGKKRIDTQVSPEEMNDRRKKWTAPAYKVNRGV
LYKYIKNVQSASDGCVTDE
;
_struct_ref.pdbx_align_begin           30 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9JPI 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 2 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 580 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q9LIR4 
_struct_ref_seq.db_align_beg                  30 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  608 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       -4 
_struct_ref_seq.pdbx_auth_seq_align_end       574 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9JPI GLY A 1   ? UNP Q9LIR4 ?   ?   'expression tag'      -5  1 
1 9JPI ALA A 531 ? UNP Q9LIR4 LYS 559 'engineered mutation' 525 2 
1 9JPI ALA A 532 ? UNP Q9LIR4 LYS 560 'engineered mutation' 526 3 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 9090  ? 
1 MORE         -101  ? 
1 'SSA (A^2)'  35900 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'equilibrium centrifugation' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z      1.0000000000 0.0000000000  0.0000000000 0.0000000000 0.0000000000  1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000  
2 'crystal symmetry operation' 8_556 -y,-x,-z+1 0.0000000000 -1.0000000000 0.0000000000 0.0000000000 -1.0000000000 0.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 66.6400000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 29  ? GLU A 34  ? SER A 23  GLU A 28  1 ? 6  
HELX_P HELX_P2  AA2 PRO A 35  ? SER A 37  ? PRO A 29  SER A 31  5 ? 3  
HELX_P HELX_P3  AA3 GLN A 38  ? VAL A 48  ? GLN A 32  VAL A 42  1 ? 11 
HELX_P HELX_P4  AA4 ASP A 53  ? LYS A 57  ? ASP A 47  LYS A 51  5 ? 5  
HELX_P HELX_P5  AA5 HIS A 75  ? ALA A 90  ? HIS A 69  ALA A 84  1 ? 16 
HELX_P HELX_P6  AA6 SER A 103 ? MET A 108 ? SER A 97  MET A 102 1 ? 6  
HELX_P HELX_P7  AA7 THR A 110 ? CYS A 114 ? THR A 104 CYS A 108 5 ? 5  
HELX_P HELX_P8  AA8 PHE A 115 ? TRP A 135 ? PHE A 109 TRP A 129 1 ? 21 
HELX_P HELX_P9  AA9 LYS A 147 ? ASN A 160 ? LYS A 141 ASN A 154 1 ? 14 
HELX_P HELX_P10 AB1 ASP A 182 ? SER A 195 ? ASP A 176 SER A 189 1 ? 14 
HELX_P HELX_P11 AB2 SER A 199 ? HIS A 209 ? SER A 193 HIS A 203 1 ? 11 
HELX_P HELX_P12 AB3 TYR A 221 ? MET A 233 ? TYR A 215 MET A 227 1 ? 13 
HELX_P HELX_P13 AB4 ASP A 247 ? ASP A 268 ? ASP A 241 ASP A 262 1 ? 22 
HELX_P HELX_P14 AB5 LYS A 270 ? ILE A 275 ? LYS A 264 ILE A 269 1 ? 6  
HELX_P HELX_P15 AB6 THR A 276 ? GLY A 291 ? THR A 270 GLY A 285 1 ? 16 
HELX_P HELX_P16 AB7 THR A 294 ? VAL A 307 ? THR A 288 VAL A 301 1 ? 14 
HELX_P HELX_P17 AB8 THR A 312 ? VAL A 323 ? THR A 306 VAL A 317 1 ? 12 
HELX_P HELX_P18 AB9 VAL A 336 ? ILE A 343 ? VAL A 330 ILE A 337 1 ? 8  
HELX_P HELX_P19 AC1 GLY A 344 ? LEU A 356 ? GLY A 338 LEU A 350 1 ? 13 
HELX_P HELX_P20 AC2 THR A 370 ? ASN A 377 ? THR A 364 ASN A 371 1 ? 8  
HELX_P HELX_P21 AC3 GLY A 434 ? ASP A 445 ? GLY A 428 ASP A 439 1 ? 12 
HELX_P HELX_P22 AC4 PRO A 446 ? LYS A 450 ? PRO A 440 LYS A 444 5 ? 5  
HELX_P HELX_P23 AC5 LEU A 471 ? ALA A 480 ? LEU A 465 ALA A 474 1 ? 10 
HELX_P HELX_P24 AC6 LEU A 482 ? CYS A 486 ? LEU A 476 CYS A 480 5 ? 5  
HELX_P HELX_P25 AC7 GLU A 509 ? GLY A 513 ? GLU A 503 GLY A 507 5 ? 5  
HELX_P HELX_P26 AC8 GLY A 514 ? ILE A 519 ? GLY A 508 ILE A 513 5 ? 6  
HELX_P HELX_P27 AC9 SER A 539 ? TRP A 550 ? SER A 533 TRP A 544 1 ? 12 
HELX_P HELX_P28 AD1 ARG A 559 ? VAL A 569 ? ARG A 553 VAL A 563 1 ? 11 
HELX_P HELX_P29 AD2 SER A 571 ? GLY A 575 ? SER A 565 GLY A 569 5 ? 5  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1 metalc ? ? A CYS 72  SG  ? ? ? 1_555 F FES . FE2 ? ? A CYS 66  A FES 605 1_555 ? ? ? ? ? ? ? 2.341 ? ? 
metalc2 metalc ? ? A ASP 104 OD2 ? ? ? 1_555 B MG  . MG  ? ? A ASP 98  A MG  601 1_555 ? ? ? ? ? ? ? 2.289 ? ? 
metalc3 metalc ? ? A CYS 145 SG  ? ? ? 1_555 F FES . FE2 ? ? A CYS 139 A FES 605 1_555 ? ? ? ? ? ? ? 2.371 ? ? 
metalc4 metalc ? ? A ASP 146 OD2 ? ? ? 1_555 B MG  . MG  ? ? A ASP 140 A MG  601 1_555 ? ? ? ? ? ? ? 2.704 ? ? 
metalc5 metalc ? ? A CYS 217 SG  ? ? ? 1_555 F FES . FE1 ? ? A CYS 211 A FES 605 1_555 ? ? ? ? ? ? ? 2.372 ? ? 
metalc6 metalc ? ? A GLU 469 OE1 ? ? ? 1_555 B MG  . MG  ? ? A GLU 463 A MG  601 1_555 ? ? ? ? ? ? ? 2.612 ? ? 
metalc7 metalc ? ? B MG  .   MG  ? ? ? 1_555 D K0O . O14 ? ? A MG  601 A K0O 603 1_555 ? ? ? ? ? ? ? 2.208 ? ? 
metalc8 metalc ? ? F FES .   FE1 ? ? ? 1_555 G HOH . O   ? ? A FES 605 A HOH 713 1_555 ? ? ? ? ? ? ? 2.762 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  SG  ? A CYS 72  ? A CYS 66  ? 1_555 FE2 ? F FES . ? A FES 605 ? 1_555 S1  ? F FES .   ? A FES 605 ? 1_555 104.4 ? 
2  SG  ? A CYS 72  ? A CYS 66  ? 1_555 FE2 ? F FES . ? A FES 605 ? 1_555 S2  ? F FES .   ? A FES 605 ? 1_555 108.9 ? 
3  S1  ? F FES .   ? A FES 605 ? 1_555 FE2 ? F FES . ? A FES 605 ? 1_555 S2  ? F FES .   ? A FES 605 ? 1_555 104.1 ? 
4  SG  ? A CYS 72  ? A CYS 66  ? 1_555 FE2 ? F FES . ? A FES 605 ? 1_555 SG  ? A CYS 145 ? A CYS 139 ? 1_555 113.1 ? 
5  S1  ? F FES .   ? A FES 605 ? 1_555 FE2 ? F FES . ? A FES 605 ? 1_555 SG  ? A CYS 145 ? A CYS 139 ? 1_555 114.4 ? 
6  S2  ? F FES .   ? A FES 605 ? 1_555 FE2 ? F FES . ? A FES 605 ? 1_555 SG  ? A CYS 145 ? A CYS 139 ? 1_555 111.3 ? 
7  OD2 ? A ASP 104 ? A ASP 98  ? 1_555 MG  ? B MG  . ? A MG  601 ? 1_555 OD2 ? A ASP 146 ? A ASP 140 ? 1_555 81.9  ? 
8  OD2 ? A ASP 104 ? A ASP 98  ? 1_555 MG  ? B MG  . ? A MG  601 ? 1_555 OE1 ? A GLU 469 ? A GLU 463 ? 1_555 83.0  ? 
9  OD2 ? A ASP 146 ? A ASP 140 ? 1_555 MG  ? B MG  . ? A MG  601 ? 1_555 OE1 ? A GLU 469 ? A GLU 463 ? 1_555 140.2 ? 
10 OD2 ? A ASP 104 ? A ASP 98  ? 1_555 MG  ? B MG  . ? A MG  601 ? 1_555 O14 ? D K0O .   ? A K0O 603 ? 1_555 81.5  ? 
11 OD2 ? A ASP 146 ? A ASP 140 ? 1_555 MG  ? B MG  . ? A MG  601 ? 1_555 O14 ? D K0O .   ? A K0O 603 ? 1_555 72.8  ? 
12 OE1 ? A GLU 469 ? A GLU 463 ? 1_555 MG  ? B MG  . ? A MG  601 ? 1_555 O14 ? D K0O .   ? A K0O 603 ? 1_555 68.6  ? 
13 SG  ? A CYS 217 ? A CYS 211 ? 1_555 FE1 ? F FES . ? A FES 605 ? 1_555 S1  ? F FES .   ? A FES 605 ? 1_555 114.3 ? 
14 SG  ? A CYS 217 ? A CYS 211 ? 1_555 FE1 ? F FES . ? A FES 605 ? 1_555 S2  ? F FES .   ? A FES 605 ? 1_555 120.8 ? 
15 S1  ? F FES .   ? A FES 605 ? 1_555 FE1 ? F FES . ? A FES 605 ? 1_555 S2  ? F FES .   ? A FES 605 ? 1_555 103.8 ? 
16 SG  ? A CYS 217 ? A CYS 211 ? 1_555 FE1 ? F FES . ? A FES 605 ? 1_555 O   ? G HOH .   ? A HOH 713 ? 1_555 91.8  ? 
17 S1  ? F FES .   ? A FES 605 ? 1_555 FE1 ? F FES . ? A FES 605 ? 1_555 O   ? G HOH .   ? A HOH 713 ? 1_555 79.1  ? 
18 S2  ? F FES .   ? A FES 605 ? 1_555 FE1 ? F FES . ? A FES 605 ? 1_555 O   ? G HOH .   ? A HOH 713 ? 1_555 140.2 ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 LYS 330 A . ? LYS 324 A PRO 331 A ? PRO 325 A 1 0.23   
2 GLY 464 A . ? GLY 458 A PRO 465 A ? PRO 459 A 1 -11.67 
3 CYS 507 A . ? CYS 501 A PRO 508 A ? PRO 502 A 1 -1.42  
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 2 ? 
AA3 ? 8 ? 
AA4 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? parallel      
AA1 3 4 ? parallel      
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? parallel      
AA3 4 5 ? parallel      
AA3 5 6 ? parallel      
AA3 6 7 ? anti-parallel 
AA3 7 8 ? anti-parallel 
AA4 1 2 ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 93  ? ASN A 98  ? VAL A 87  ASN A 92  
AA1 2 GLN A 59  ? SER A 64  ? GLN A 53  SER A 58  
AA1 3 GLY A 138 ? ILE A 142 ? GLY A 132 ILE A 136 
AA1 4 GLY A 163 ? MET A 165 ? GLY A 157 MET A 159 
AA2 1 GLY A 174 ? HIS A 175 ? GLY A 168 HIS A 169 
AA2 2 THR A 180 ? TYR A 181 ? THR A 174 TYR A 175 
AA3 1 ILE A 401 ? ILE A 403 ? ILE A 395 ILE A 397 
AA3 2 GLY A 412 ? LYS A 416 ? GLY A 406 LYS A 410 
AA3 3 VAL A 502 ? CYS A 507 ? VAL A 496 CYS A 501 
AA3 4 ALA A 487 ? THR A 490 ? ALA A 481 THR A 484 
AA3 5 VAL A 453 ? ARG A 457 ? VAL A 447 ARG A 451 
AA3 6 TYR A 424 ? GLU A 433 ? TYR A 418 GLU A 427 
AA3 7 ILE A 524 ? ASP A 528 ? ILE A 518 ASP A 522 
AA3 8 ARG A 533 ? THR A 536 ? ARG A 527 THR A 530 
AA4 1 GLU A 469 ? MET A 470 ? GLU A 463 MET A 464 
AA4 2 ARG A 493 ? PHE A 494 ? ARG A 487 PHE A 488 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O VAL A 93  ? O VAL A 87  N ILE A 60  ? N ILE A 54  
AA1 2 3 N GLY A 61  ? N GLY A 55  O GLY A 138 ? O GLY A 132 
AA1 3 4 N SER A 141 ? N SER A 135 O ILE A 164 ? O ILE A 158 
AA2 1 2 N GLY A 174 ? N GLY A 168 O TYR A 181 ? O TYR A 175 
AA3 1 2 N GLN A 402 ? N GLN A 396 O ALA A 415 ? O ALA A 409 
AA3 2 3 N VAL A 414 ? N VAL A 408 O GLY A 504 ? O GLY A 498 
AA3 3 4 O VAL A 503 ? O VAL A 497 N LEU A 488 ? N LEU A 482 
AA3 4 5 O ALA A 487 ? O ALA A 481 N VAL A 454 ? N VAL A 448 
AA3 5 6 O VAL A 455 ? O VAL A 449 N PHE A 432 ? N PHE A 426 
AA3 6 7 N PHE A 425 ? N PHE A 419 O ILE A 527 ? O ILE A 521 
AA3 7 8 N THR A 526 ? N THR A 520 O ASP A 535 ? O ASP A 529 
AA4 1 2 N MET A 470 ? N MET A 464 O ARG A 493 ? O ARG A 487 
# 
_pdbx_entry_details.entry_id                   9JPI 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ALA A 7   ? ? -135.24 -49.36  
2 1 ASN A 17  ? ? 74.45   -25.17  
3 1 ASN A 20  ? ? -108.90 57.26   
4 1 ASP A 140 ? ? -12.41  -84.92  
5 1 MET A 214 ? ? -78.72  48.85   
6 1 TYR A 233 ? ? 79.61   -8.07   
7 1 ARG A 399 ? ? -117.57 -128.52 
8 1 SER A 489 ? ? -100.66 -62.81  
# 
_pdbx_struct_special_symmetry.id              1 
_pdbx_struct_special_symmetry.PDB_model_num   1 
_pdbx_struct_special_symmetry.auth_asym_id    A 
_pdbx_struct_special_symmetry.auth_comp_id    HOH 
_pdbx_struct_special_symmetry.auth_seq_id     735 
_pdbx_struct_special_symmetry.PDB_ins_code    ? 
_pdbx_struct_special_symmetry.label_asym_id   G 
_pdbx_struct_special_symmetry.label_comp_id   HOH 
_pdbx_struct_special_symmetry.label_seq_id    . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z               
2 -y+1/2,x+1/2,z+1/2  
3 y+1/2,-x+1/2,z+1/2  
4 x+1/2,-y+1/2,-z+1/2 
5 -x+1/2,y+1/2,-z+1/2 
6 -x,-y,z             
7 y,x,-z              
8 -y,-x,-z            
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      A 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       966 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   6.18 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY -5 ? A GLY 1  
2  1 Y 1 A SER -4 ? A SER 2  
3  1 Y 1 A ILE -3 ? A ILE 3  
4  1 Y 1 A ILE -2 ? A ILE 4  
5  1 Y 1 A SER -1 ? A SER 5  
6  1 Y 1 A CYS 0  ? A CYS 6  
7  1 Y 1 A SER 1  ? A SER 7  
8  1 Y 1 A ALA 2  ? A ALA 8  
9  1 Y 1 A ILE 13 ? A ILE 19 
10 1 Y 1 A THR 14 ? A THR 20 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CYS N    N  N N 74  
CYS CA   C  N R 75  
CYS C    C  N N 76  
CYS O    O  N N 77  
CYS CB   C  N N 78  
CYS SG   S  N N 79  
CYS OXT  O  N N 80  
CYS H    H  N N 81  
CYS H2   H  N N 82  
CYS HA   H  N N 83  
CYS HB2  H  N N 84  
CYS HB3  H  N N 85  
CYS HG   H  N N 86  
CYS HXT  H  N N 87  
FES FE1  FE N N 88  
FES FE2  FE N N 89  
FES S1   S  N N 90  
FES S2   S  N N 91  
GLN N    N  N N 92  
GLN CA   C  N S 93  
GLN C    C  N N 94  
GLN O    O  N N 95  
GLN CB   C  N N 96  
GLN CG   C  N N 97  
GLN CD   C  N N 98  
GLN OE1  O  N N 99  
GLN NE2  N  N N 100 
GLN OXT  O  N N 101 
GLN H    H  N N 102 
GLN H2   H  N N 103 
GLN HA   H  N N 104 
GLN HB2  H  N N 105 
GLN HB3  H  N N 106 
GLN HG2  H  N N 107 
GLN HG3  H  N N 108 
GLN HE21 H  N N 109 
GLN HE22 H  N N 110 
GLN HXT  H  N N 111 
GLU N    N  N N 112 
GLU CA   C  N S 113 
GLU C    C  N N 114 
GLU O    O  N N 115 
GLU CB   C  N N 116 
GLU CG   C  N N 117 
GLU CD   C  N N 118 
GLU OE1  O  N N 119 
GLU OE2  O  N N 120 
GLU OXT  O  N N 121 
GLU H    H  N N 122 
GLU H2   H  N N 123 
GLU HA   H  N N 124 
GLU HB2  H  N N 125 
GLU HB3  H  N N 126 
GLU HG2  H  N N 127 
GLU HG3  H  N N 128 
GLU HE2  H  N N 129 
GLU HXT  H  N N 130 
GLY N    N  N N 131 
GLY CA   C  N N 132 
GLY C    C  N N 133 
GLY O    O  N N 134 
GLY OXT  O  N N 135 
GLY H    H  N N 136 
GLY H2   H  N N 137 
GLY HA2  H  N N 138 
GLY HA3  H  N N 139 
GLY HXT  H  N N 140 
HIS N    N  N N 141 
HIS CA   C  N S 142 
HIS C    C  N N 143 
HIS O    O  N N 144 
HIS CB   C  N N 145 
HIS CG   C  Y N 146 
HIS ND1  N  Y N 147 
HIS CD2  C  Y N 148 
HIS CE1  C  Y N 149 
HIS NE2  N  Y N 150 
HIS OXT  O  N N 151 
HIS H    H  N N 152 
HIS H2   H  N N 153 
HIS HA   H  N N 154 
HIS HB2  H  N N 155 
HIS HB3  H  N N 156 
HIS HD1  H  N N 157 
HIS HD2  H  N N 158 
HIS HE1  H  N N 159 
HIS HE2  H  N N 160 
HIS HXT  H  N N 161 
HOH O    O  N N 162 
HOH H1   H  N N 163 
HOH H2   H  N N 164 
ILE N    N  N N 165 
ILE CA   C  N S 166 
ILE C    C  N N 167 
ILE O    O  N N 168 
ILE CB   C  N S 169 
ILE CG1  C  N N 170 
ILE CG2  C  N N 171 
ILE CD1  C  N N 172 
ILE OXT  O  N N 173 
ILE H    H  N N 174 
ILE H2   H  N N 175 
ILE HA   H  N N 176 
ILE HB   H  N N 177 
ILE HG12 H  N N 178 
ILE HG13 H  N N 179 
ILE HG21 H  N N 180 
ILE HG22 H  N N 181 
ILE HG23 H  N N 182 
ILE HD11 H  N N 183 
ILE HD12 H  N N 184 
ILE HD13 H  N N 185 
ILE HXT  H  N N 186 
K0O C11  C  N N 187 
K0O C12  C  N R 188 
K0O C13  C  N R 189 
K0O C15  C  N N 190 
K0O O16  O  N N 191 
K0O C18  C  N N 192 
K0O C19  C  N N 193 
K0O C01  C  N S 194 
K0O C02  C  N S 195 
K0O C03  C  N N 196 
K0O C04  C  N N 197 
K0O C05  C  N N 198 
K0O C06  C  N N 199 
K0O C07  C  N N 200 
K0O C08  C  N N 201 
K0O C09  C  N N 202 
K0O O10  O  N N 203 
K0O O14  O  N N 204 
K0O O17  O  N N 205 
K0O H1   H  N N 206 
K0O H2   H  N N 207 
K0O H3   H  N N 208 
K0O H4   H  N N 209 
K0O H5   H  N N 210 
K0O H6   H  N N 211 
K0O H7   H  N N 212 
K0O H8   H  N N 213 
K0O H9   H  N N 214 
K0O H10  H  N N 215 
K0O H11  H  N N 216 
K0O H12  H  N N 217 
K0O H15  H  N N 218 
K0O H16  H  N N 219 
K0O H17  H  N N 220 
K0O H18  H  N N 221 
K0O H19  H  N N 222 
K0O H20  H  N N 223 
K0O H21  H  N N 224 
K0O H22  H  N N 225 
K0O H23  H  N N 226 
K0O H24  H  N N 227 
LEU N    N  N N 228 
LEU CA   C  N S 229 
LEU C    C  N N 230 
LEU O    O  N N 231 
LEU CB   C  N N 232 
LEU CG   C  N N 233 
LEU CD1  C  N N 234 
LEU CD2  C  N N 235 
LEU OXT  O  N N 236 
LEU H    H  N N 237 
LEU H2   H  N N 238 
LEU HA   H  N N 239 
LEU HB2  H  N N 240 
LEU HB3  H  N N 241 
LEU HG   H  N N 242 
LEU HD11 H  N N 243 
LEU HD12 H  N N 244 
LEU HD13 H  N N 245 
LEU HD21 H  N N 246 
LEU HD22 H  N N 247 
LEU HD23 H  N N 248 
LEU HXT  H  N N 249 
LYS N    N  N N 250 
LYS CA   C  N S 251 
LYS C    C  N N 252 
LYS O    O  N N 253 
LYS CB   C  N N 254 
LYS CG   C  N N 255 
LYS CD   C  N N 256 
LYS CE   C  N N 257 
LYS NZ   N  N N 258 
LYS OXT  O  N N 259 
LYS H    H  N N 260 
LYS H2   H  N N 261 
LYS HA   H  N N 262 
LYS HB2  H  N N 263 
LYS HB3  H  N N 264 
LYS HG2  H  N N 265 
LYS HG3  H  N N 266 
LYS HD2  H  N N 267 
LYS HD3  H  N N 268 
LYS HE2  H  N N 269 
LYS HE3  H  N N 270 
LYS HZ1  H  N N 271 
LYS HZ2  H  N N 272 
LYS HZ3  H  N N 273 
LYS HXT  H  N N 274 
MET N    N  N N 275 
MET CA   C  N S 276 
MET C    C  N N 277 
MET O    O  N N 278 
MET CB   C  N N 279 
MET CG   C  N N 280 
MET SD   S  N N 281 
MET CE   C  N N 282 
MET OXT  O  N N 283 
MET H    H  N N 284 
MET H2   H  N N 285 
MET HA   H  N N 286 
MET HB2  H  N N 287 
MET HB3  H  N N 288 
MET HG2  H  N N 289 
MET HG3  H  N N 290 
MET HE1  H  N N 291 
MET HE2  H  N N 292 
MET HE3  H  N N 293 
MET HXT  H  N N 294 
MG  MG   MG N N 295 
PHE N    N  N N 296 
PHE CA   C  N S 297 
PHE C    C  N N 298 
PHE O    O  N N 299 
PHE CB   C  N N 300 
PHE CG   C  Y N 301 
PHE CD1  C  Y N 302 
PHE CD2  C  Y N 303 
PHE CE1  C  Y N 304 
PHE CE2  C  Y N 305 
PHE CZ   C  Y N 306 
PHE OXT  O  N N 307 
PHE H    H  N N 308 
PHE H2   H  N N 309 
PHE HA   H  N N 310 
PHE HB2  H  N N 311 
PHE HB3  H  N N 312 
PHE HD1  H  N N 313 
PHE HD2  H  N N 314 
PHE HE1  H  N N 315 
PHE HE2  H  N N 316 
PHE HZ   H  N N 317 
PHE HXT  H  N N 318 
PRO N    N  N N 319 
PRO CA   C  N S 320 
PRO C    C  N N 321 
PRO O    O  N N 322 
PRO CB   C  N N 323 
PRO CG   C  N N 324 
PRO CD   C  N N 325 
PRO OXT  O  N N 326 
PRO H    H  N N 327 
PRO HA   H  N N 328 
PRO HB2  H  N N 329 
PRO HB3  H  N N 330 
PRO HG2  H  N N 331 
PRO HG3  H  N N 332 
PRO HD2  H  N N 333 
PRO HD3  H  N N 334 
PRO HXT  H  N N 335 
SER N    N  N N 336 
SER CA   C  N S 337 
SER C    C  N N 338 
SER O    O  N N 339 
SER CB   C  N N 340 
SER OG   O  N N 341 
SER OXT  O  N N 342 
SER H    H  N N 343 
SER H2   H  N N 344 
SER HA   H  N N 345 
SER HB2  H  N N 346 
SER HB3  H  N N 347 
SER HG   H  N N 348 
SER HXT  H  N N 349 
SO4 S    S  N N 350 
SO4 O1   O  N N 351 
SO4 O2   O  N N 352 
SO4 O3   O  N N 353 
SO4 O4   O  N N 354 
THR N    N  N N 355 
THR CA   C  N S 356 
THR C    C  N N 357 
THR O    O  N N 358 
THR CB   C  N R 359 
THR OG1  O  N N 360 
THR CG2  C  N N 361 
THR OXT  O  N N 362 
THR H    H  N N 363 
THR H2   H  N N 364 
THR HA   H  N N 365 
THR HB   H  N N 366 
THR HG1  H  N N 367 
THR HG21 H  N N 368 
THR HG22 H  N N 369 
THR HG23 H  N N 370 
THR HXT  H  N N 371 
TRP N    N  N N 372 
TRP CA   C  N S 373 
TRP C    C  N N 374 
TRP O    O  N N 375 
TRP CB   C  N N 376 
TRP CG   C  Y N 377 
TRP CD1  C  Y N 378 
TRP CD2  C  Y N 379 
TRP NE1  N  Y N 380 
TRP CE2  C  Y N 381 
TRP CE3  C  Y N 382 
TRP CZ2  C  Y N 383 
TRP CZ3  C  Y N 384 
TRP CH2  C  Y N 385 
TRP OXT  O  N N 386 
TRP H    H  N N 387 
TRP H2   H  N N 388 
TRP HA   H  N N 389 
TRP HB2  H  N N 390 
TRP HB3  H  N N 391 
TRP HD1  H  N N 392 
TRP HE1  H  N N 393 
TRP HE3  H  N N 394 
TRP HZ2  H  N N 395 
TRP HZ3  H  N N 396 
TRP HH2  H  N N 397 
TRP HXT  H  N N 398 
TYR N    N  N N 399 
TYR CA   C  N S 400 
TYR C    C  N N 401 
TYR O    O  N N 402 
TYR CB   C  N N 403 
TYR CG   C  Y N 404 
TYR CD1  C  Y N 405 
TYR CD2  C  Y N 406 
TYR CE1  C  Y N 407 
TYR CE2  C  Y N 408 
TYR CZ   C  Y N 409 
TYR OH   O  N N 410 
TYR OXT  O  N N 411 
TYR H    H  N N 412 
TYR H2   H  N N 413 
TYR HA   H  N N 414 
TYR HB2  H  N N 415 
TYR HB3  H  N N 416 
TYR HD1  H  N N 417 
TYR HD2  H  N N 418 
TYR HE1  H  N N 419 
TYR HE2  H  N N 420 
TYR HH   H  N N 421 
TYR HXT  H  N N 422 
VAL N    N  N N 423 
VAL CA   C  N S 424 
VAL C    C  N N 425 
VAL O    O  N N 426 
VAL CB   C  N N 427 
VAL CG1  C  N N 428 
VAL CG2  C  N N 429 
VAL OXT  O  N N 430 
VAL H    H  N N 431 
VAL H2   H  N N 432 
VAL HA   H  N N 433 
VAL HB   H  N N 434 
VAL HG11 H  N N 435 
VAL HG12 H  N N 436 
VAL HG13 H  N N 437 
VAL HG21 H  N N 438 
VAL HG22 H  N N 439 
VAL HG23 H  N N 440 
VAL HXT  H  N N 441 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
FES FE1 S1   sing N N 83  
FES FE1 S2   sing N N 84  
FES FE2 S1   sing N N 85  
FES FE2 S2   sing N N 86  
GLN N   CA   sing N N 87  
GLN N   H    sing N N 88  
GLN N   H2   sing N N 89  
GLN CA  C    sing N N 90  
GLN CA  CB   sing N N 91  
GLN CA  HA   sing N N 92  
GLN C   O    doub N N 93  
GLN C   OXT  sing N N 94  
GLN CB  CG   sing N N 95  
GLN CB  HB2  sing N N 96  
GLN CB  HB3  sing N N 97  
GLN CG  CD   sing N N 98  
GLN CG  HG2  sing N N 99  
GLN CG  HG3  sing N N 100 
GLN CD  OE1  doub N N 101 
GLN CD  NE2  sing N N 102 
GLN NE2 HE21 sing N N 103 
GLN NE2 HE22 sing N N 104 
GLN OXT HXT  sing N N 105 
GLU N   CA   sing N N 106 
GLU N   H    sing N N 107 
GLU N   H2   sing N N 108 
GLU CA  C    sing N N 109 
GLU CA  CB   sing N N 110 
GLU CA  HA   sing N N 111 
GLU C   O    doub N N 112 
GLU C   OXT  sing N N 113 
GLU CB  CG   sing N N 114 
GLU CB  HB2  sing N N 115 
GLU CB  HB3  sing N N 116 
GLU CG  CD   sing N N 117 
GLU CG  HG2  sing N N 118 
GLU CG  HG3  sing N N 119 
GLU CD  OE1  doub N N 120 
GLU CD  OE2  sing N N 121 
GLU OE2 HE2  sing N N 122 
GLU OXT HXT  sing N N 123 
GLY N   CA   sing N N 124 
GLY N   H    sing N N 125 
GLY N   H2   sing N N 126 
GLY CA  C    sing N N 127 
GLY CA  HA2  sing N N 128 
GLY CA  HA3  sing N N 129 
GLY C   O    doub N N 130 
GLY C   OXT  sing N N 131 
GLY OXT HXT  sing N N 132 
HIS N   CA   sing N N 133 
HIS N   H    sing N N 134 
HIS N   H2   sing N N 135 
HIS CA  C    sing N N 136 
HIS CA  CB   sing N N 137 
HIS CA  HA   sing N N 138 
HIS C   O    doub N N 139 
HIS C   OXT  sing N N 140 
HIS CB  CG   sing N N 141 
HIS CB  HB2  sing N N 142 
HIS CB  HB3  sing N N 143 
HIS CG  ND1  sing Y N 144 
HIS CG  CD2  doub Y N 145 
HIS ND1 CE1  doub Y N 146 
HIS ND1 HD1  sing N N 147 
HIS CD2 NE2  sing Y N 148 
HIS CD2 HD2  sing N N 149 
HIS CE1 NE2  sing Y N 150 
HIS CE1 HE1  sing N N 151 
HIS NE2 HE2  sing N N 152 
HIS OXT HXT  sing N N 153 
HOH O   H1   sing N N 154 
HOH O   H2   sing N N 155 
ILE N   CA   sing N N 156 
ILE N   H    sing N N 157 
ILE N   H2   sing N N 158 
ILE CA  C    sing N N 159 
ILE CA  CB   sing N N 160 
ILE CA  HA   sing N N 161 
ILE C   O    doub N N 162 
ILE C   OXT  sing N N 163 
ILE CB  CG1  sing N N 164 
ILE CB  CG2  sing N N 165 
ILE CB  HB   sing N N 166 
ILE CG1 CD1  sing N N 167 
ILE CG1 HG12 sing N N 168 
ILE CG1 HG13 sing N N 169 
ILE CG2 HG21 sing N N 170 
ILE CG2 HG22 sing N N 171 
ILE CG2 HG23 sing N N 172 
ILE CD1 HD11 sing N N 173 
ILE CD1 HD12 sing N N 174 
ILE CD1 HD13 sing N N 175 
ILE OXT HXT  sing N N 176 
K0O O16 C15  doub N N 177 
K0O C15 O17  sing N N 178 
K0O C15 C13  sing N N 179 
K0O O14 C13  sing N N 180 
K0O O10 C12  sing N N 181 
K0O O10 C09  sing N N 182 
K0O C13 C12  sing N N 183 
K0O C13 C18  sing N N 184 
K0O C12 C11  sing N N 185 
K0O C09 C02  sing N N 186 
K0O C11 C02  sing N N 187 
K0O C18 C19  sing N N 188 
K0O C02 C03  sing N N 189 
K0O C02 C01  sing N N 190 
K0O C19 C01  sing N N 191 
K0O C03 C04  sing N N 192 
K0O C01 C05  sing N N 193 
K0O C04 C05  sing N N 194 
K0O C05 C06  doub N N 195 
K0O C06 C07  sing N N 196 
K0O C06 C08  sing N N 197 
K0O C11 H1   sing N N 198 
K0O C11 H2   sing N N 199 
K0O C12 H3   sing N N 200 
K0O C18 H4   sing N N 201 
K0O C18 H5   sing N N 202 
K0O C19 H6   sing N N 203 
K0O C19 H7   sing N N 204 
K0O C01 H8   sing N N 205 
K0O C03 H9   sing N N 206 
K0O C03 H10  sing N N 207 
K0O C04 H11  sing N N 208 
K0O C04 H12  sing N N 209 
K0O C07 H15  sing N N 210 
K0O C07 H16  sing N N 211 
K0O C07 H17  sing N N 212 
K0O C08 H18  sing N N 213 
K0O C08 H19  sing N N 214 
K0O C08 H20  sing N N 215 
K0O C09 H21  sing N N 216 
K0O C09 H22  sing N N 217 
K0O O14 H23  sing N N 218 
K0O O17 H24  sing N N 219 
LEU N   CA   sing N N 220 
LEU N   H    sing N N 221 
LEU N   H2   sing N N 222 
LEU CA  C    sing N N 223 
LEU CA  CB   sing N N 224 
LEU CA  HA   sing N N 225 
LEU C   O    doub N N 226 
LEU C   OXT  sing N N 227 
LEU CB  CG   sing N N 228 
LEU CB  HB2  sing N N 229 
LEU CB  HB3  sing N N 230 
LEU CG  CD1  sing N N 231 
LEU CG  CD2  sing N N 232 
LEU CG  HG   sing N N 233 
LEU CD1 HD11 sing N N 234 
LEU CD1 HD12 sing N N 235 
LEU CD1 HD13 sing N N 236 
LEU CD2 HD21 sing N N 237 
LEU CD2 HD22 sing N N 238 
LEU CD2 HD23 sing N N 239 
LEU OXT HXT  sing N N 240 
LYS N   CA   sing N N 241 
LYS N   H    sing N N 242 
LYS N   H2   sing N N 243 
LYS CA  C    sing N N 244 
LYS CA  CB   sing N N 245 
LYS CA  HA   sing N N 246 
LYS C   O    doub N N 247 
LYS C   OXT  sing N N 248 
LYS CB  CG   sing N N 249 
LYS CB  HB2  sing N N 250 
LYS CB  HB3  sing N N 251 
LYS CG  CD   sing N N 252 
LYS CG  HG2  sing N N 253 
LYS CG  HG3  sing N N 254 
LYS CD  CE   sing N N 255 
LYS CD  HD2  sing N N 256 
LYS CD  HD3  sing N N 257 
LYS CE  NZ   sing N N 258 
LYS CE  HE2  sing N N 259 
LYS CE  HE3  sing N N 260 
LYS NZ  HZ1  sing N N 261 
LYS NZ  HZ2  sing N N 262 
LYS NZ  HZ3  sing N N 263 
LYS OXT HXT  sing N N 264 
MET N   CA   sing N N 265 
MET N   H    sing N N 266 
MET N   H2   sing N N 267 
MET CA  C    sing N N 268 
MET CA  CB   sing N N 269 
MET CA  HA   sing N N 270 
MET C   O    doub N N 271 
MET C   OXT  sing N N 272 
MET CB  CG   sing N N 273 
MET CB  HB2  sing N N 274 
MET CB  HB3  sing N N 275 
MET CG  SD   sing N N 276 
MET CG  HG2  sing N N 277 
MET CG  HG3  sing N N 278 
MET SD  CE   sing N N 279 
MET CE  HE1  sing N N 280 
MET CE  HE2  sing N N 281 
MET CE  HE3  sing N N 282 
MET OXT HXT  sing N N 283 
PHE N   CA   sing N N 284 
PHE N   H    sing N N 285 
PHE N   H2   sing N N 286 
PHE CA  C    sing N N 287 
PHE CA  CB   sing N N 288 
PHE CA  HA   sing N N 289 
PHE C   O    doub N N 290 
PHE C   OXT  sing N N 291 
PHE CB  CG   sing N N 292 
PHE CB  HB2  sing N N 293 
PHE CB  HB3  sing N N 294 
PHE CG  CD1  doub Y N 295 
PHE CG  CD2  sing Y N 296 
PHE CD1 CE1  sing Y N 297 
PHE CD1 HD1  sing N N 298 
PHE CD2 CE2  doub Y N 299 
PHE CD2 HD2  sing N N 300 
PHE CE1 CZ   doub Y N 301 
PHE CE1 HE1  sing N N 302 
PHE CE2 CZ   sing Y N 303 
PHE CE2 HE2  sing N N 304 
PHE CZ  HZ   sing N N 305 
PHE OXT HXT  sing N N 306 
PRO N   CA   sing N N 307 
PRO N   CD   sing N N 308 
PRO N   H    sing N N 309 
PRO CA  C    sing N N 310 
PRO CA  CB   sing N N 311 
PRO CA  HA   sing N N 312 
PRO C   O    doub N N 313 
PRO C   OXT  sing N N 314 
PRO CB  CG   sing N N 315 
PRO CB  HB2  sing N N 316 
PRO CB  HB3  sing N N 317 
PRO CG  CD   sing N N 318 
PRO CG  HG2  sing N N 319 
PRO CG  HG3  sing N N 320 
PRO CD  HD2  sing N N 321 
PRO CD  HD3  sing N N 322 
PRO OXT HXT  sing N N 323 
SER N   CA   sing N N 324 
SER N   H    sing N N 325 
SER N   H2   sing N N 326 
SER CA  C    sing N N 327 
SER CA  CB   sing N N 328 
SER CA  HA   sing N N 329 
SER C   O    doub N N 330 
SER C   OXT  sing N N 331 
SER CB  OG   sing N N 332 
SER CB  HB2  sing N N 333 
SER CB  HB3  sing N N 334 
SER OG  HG   sing N N 335 
SER OXT HXT  sing N N 336 
SO4 S   O1   doub N N 337 
SO4 S   O2   doub N N 338 
SO4 S   O3   sing N N 339 
SO4 S   O4   sing N N 340 
THR N   CA   sing N N 341 
THR N   H    sing N N 342 
THR N   H2   sing N N 343 
THR CA  C    sing N N 344 
THR CA  CB   sing N N 345 
THR CA  HA   sing N N 346 
THR C   O    doub N N 347 
THR C   OXT  sing N N 348 
THR CB  OG1  sing N N 349 
THR CB  CG2  sing N N 350 
THR CB  HB   sing N N 351 
THR OG1 HG1  sing N N 352 
THR CG2 HG21 sing N N 353 
THR CG2 HG22 sing N N 354 
THR CG2 HG23 sing N N 355 
THR OXT HXT  sing N N 356 
TRP N   CA   sing N N 357 
TRP N   H    sing N N 358 
TRP N   H2   sing N N 359 
TRP CA  C    sing N N 360 
TRP CA  CB   sing N N 361 
TRP CA  HA   sing N N 362 
TRP C   O    doub N N 363 
TRP C   OXT  sing N N 364 
TRP CB  CG   sing N N 365 
TRP CB  HB2  sing N N 366 
TRP CB  HB3  sing N N 367 
TRP CG  CD1  doub Y N 368 
TRP CG  CD2  sing Y N 369 
TRP CD1 NE1  sing Y N 370 
TRP CD1 HD1  sing N N 371 
TRP CD2 CE2  doub Y N 372 
TRP CD2 CE3  sing Y N 373 
TRP NE1 CE2  sing Y N 374 
TRP NE1 HE1  sing N N 375 
TRP CE2 CZ2  sing Y N 376 
TRP CE3 CZ3  doub Y N 377 
TRP CE3 HE3  sing N N 378 
TRP CZ2 CH2  doub Y N 379 
TRP CZ2 HZ2  sing N N 380 
TRP CZ3 CH2  sing Y N 381 
TRP CZ3 HZ3  sing N N 382 
TRP CH2 HH2  sing N N 383 
TRP OXT HXT  sing N N 384 
TYR N   CA   sing N N 385 
TYR N   H    sing N N 386 
TYR N   H2   sing N N 387 
TYR CA  C    sing N N 388 
TYR CA  CB   sing N N 389 
TYR CA  HA   sing N N 390 
TYR C   O    doub N N 391 
TYR C   OXT  sing N N 392 
TYR CB  CG   sing N N 393 
TYR CB  HB2  sing N N 394 
TYR CB  HB3  sing N N 395 
TYR CG  CD1  doub Y N 396 
TYR CG  CD2  sing Y N 397 
TYR CD1 CE1  sing Y N 398 
TYR CD1 HD1  sing N N 399 
TYR CD2 CE2  doub Y N 400 
TYR CD2 HD2  sing N N 401 
TYR CE1 CZ   doub Y N 402 
TYR CE1 HE1  sing N N 403 
TYR CE2 CZ   sing Y N 404 
TYR CE2 HE2  sing N N 405 
TYR CZ  OH   sing N N 406 
TYR OH  HH   sing N N 407 
TYR OXT HXT  sing N N 408 
VAL N   CA   sing N N 409 
VAL N   H    sing N N 410 
VAL N   H2   sing N N 411 
VAL CA  C    sing N N 412 
VAL CA  CB   sing N N 413 
VAL CA  HA   sing N N 414 
VAL C   O    doub N N 415 
VAL C   OXT  sing N N 416 
VAL CB  CG1  sing N N 417 
VAL CB  CG2  sing N N 418 
VAL CB  HB   sing N N 419 
VAL CG1 HG11 sing N N 420 
VAL CG1 HG12 sing N N 421 
VAL CG1 HG13 sing N N 422 
VAL CG2 HG21 sing N N 423 
VAL CG2 HG22 sing N N 424 
VAL CG2 HG23 sing N N 425 
VAL OXT HXT  sing N N 426 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   5ZE4 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 42 21 2' 
_space_group.name_Hall        'P 4n 2n' 
_space_group.IT_number        94 
_space_group.crystal_system   tetragonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    9JPI 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.007359 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.007359 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.015006 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356  2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
FE ? ? 20.90327 4.99816 ? ? 2.55100  38.46870 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
MG ? ? 9.41153  2.53737 ? ? 2.59044  63.03566 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032  2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882  3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732  6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . GLN A 1 9   ? 24.31100 -6.31100  49.12300 1.000 50.47922 ? 3   GLN A N   1 
ATOM   2    C  CA  . GLN A 1 9   ? 25.50500 -6.91900  49.70100 1.000 57.18970 ? 3   GLN A CA  1 
ATOM   3    C  C   . GLN A 1 9   ? 25.16500 -8.18300  50.48600 1.000 55.08100 ? 3   GLN A C   1 
ATOM   4    O  O   . GLN A 1 9   ? 26.02900 -9.04000  50.69100 1.000 58.05023 ? 3   GLN A O   1 
ATOM   5    C  CB  . GLN A 1 9   ? 26.23800 -5.92300  50.60300 1.000 54.05995 ? 3   GLN A CB  1 
ATOM   6    C  CG  . GLN A 1 9   ? 27.55800 -6.43600  51.16800 1.000 56.29033 ? 3   GLN A CG  1 
ATOM   7    C  CD  . GLN A 1 9   ? 28.13700 -5.49000  52.19400 1.000 64.13843 ? 3   GLN A CD  1 
ATOM   8    O  OE1 . GLN A 1 9   ? 27.99500 -5.70400  53.40100 1.000 65.79599 ? 3   GLN A OE1 1 
ATOM   9    N  NE2 . GLN A 1 9   ? 28.80200 -4.43900  51.72400 1.000 65.47872 ? 3   GLN A NE2 1 
ATOM   10   N  N   . SER A 1 10  ? 23.91100 -8.29900  50.92200 1.000 48.79135 ? 4   SER A N   1 
ATOM   11   C  CA  . SER A 1 10  ? 23.44600 -9.51200  51.60000 1.000 56.31526 ? 4   SER A CA  1 
ATOM   12   C  C   . SER A 1 10  ? 23.05800 -10.55000 50.55400 1.000 49.92499 ? 4   SER A C   1 
ATOM   13   O  O   . SER A 1 10  ? 21.94100 -10.53800 50.03300 1.000 53.81379 ? 4   SER A O   1 
ATOM   14   C  CB  . SER A 1 10  ? 22.27000 -9.21700  52.52000 1.000 57.03403 ? 4   SER A CB  1 
ATOM   15   O  OG  . SER A 1 10  ? 22.00900 -10.35300 53.33200 1.000 57.82562 ? 4   SER A OG  1 
ATOM   16   N  N   . VAL A 1 11  ? 23.97700 -11.46100 50.25500 1.000 47.80794 ? 5   VAL A N   1 
ATOM   17   C  CA  . VAL A 1 11  ? 23.76000 -12.49400 49.25200 1.000 42.56766 ? 5   VAL A CA  1 
ATOM   18   C  C   . VAL A 1 11  ? 23.07700 -13.68800 49.91200 1.000 43.57581 ? 5   VAL A C   1 
ATOM   19   O  O   . VAL A 1 11  ? 23.51000 -14.16200 50.96900 1.000 41.47902 ? 5   VAL A O   1 
ATOM   20   C  CB  . VAL A 1 11  ? 25.09100 -12.89600 48.59600 1.000 38.21693 ? 5   VAL A CB  1 
ATOM   21   C  CG1 . VAL A 1 11  ? 24.90700 -14.07200 47.64500 1.000 33.08957 ? 5   VAL A CG1 1 
ATOM   22   C  CG2 . VAL A 1 11  ? 25.67600 -11.71300 47.85200 1.000 40.64876 ? 5   VAL A CG2 1 
ATOM   23   N  N   . THR A 1 12  ? 21.99300 -14.15600 49.30000 1.000 34.48135 ? 6   THR A N   1 
ATOM   24   C  CA  . THR A 1 12  ? 21.31000 -15.38600 49.69800 1.000 32.67279 ? 6   THR A CA  1 
ATOM   25   C  C   . THR A 1 12  ? 21.22700 -16.28200 48.46700 1.000 32.50353 ? 6   THR A C   1 
ATOM   26   O  O   . THR A 1 12  ? 20.45400 -16.00100 47.54400 1.000 27.84066 ? 6   THR A O   1 
ATOM   27   C  CB  . THR A 1 12  ? 19.91600 -15.09000 50.25500 1.000 32.91185 ? 6   THR A CB  1 
ATOM   28   O  OG1 . THR A 1 12  ? 20.01800 -14.13200 51.31500 1.000 38.14516 ? 6   THR A OG1 1 
ATOM   29   C  CG2 . THR A 1 12  ? 19.27000 -16.36300 50.76700 1.000 32.77502 ? 6   THR A CG2 1 
ATOM   30   N  N   . ALA A 1 13  ? 22.05300 -17.32600 48.42200 1.000 29.29562 ? 7   ALA A N   1 
ATOM   31   C  CA  . ALA A 1 13  ? 22.10900 -18.15600 47.22300 1.000 26.87840 ? 7   ALA A CA  1 
ATOM   32   C  C   . ALA A 1 13  ? 22.10800 -19.63100 47.59300 1.000 21.97003 ? 7   ALA A C   1 
ATOM   33   O  O   . ALA A 1 13  ? 21.31800 -20.40800 47.03900 1.000 24.32968 ? 7   ALA A O   1 
ATOM   34   C  CB  . ALA A 1 13  ? 23.35300 -17.82200 46.37700 1.000 21.05352 ? 7   ALA A CB  1 
ATOM   35   N  N   . ASP A 1 14  ? 22.97500 -20.02100 48.52500 1.000 21.60942 ? 8   ASP A N   1 
ATOM   36   C  CA  . ASP A 1 14  ? 23.32500 -21.41100 48.78100 1.000 22.84284 ? 8   ASP A CA  1 
ATOM   37   C  C   . ASP A 1 14  ? 23.15500 -21.76100 50.25000 1.000 26.08047 ? 8   ASP A C   1 
ATOM   38   O  O   . ASP A 1 14  ? 23.11900 -20.87200 51.10500 1.000 24.29306 ? 8   ASP A O   1 
ATOM   39   C  CB  . ASP A 1 14  ? 24.77200 -21.67100 48.34700 1.000 20.63606 ? 8   ASP A CB  1 
ATOM   40   C  CG  . ASP A 1 14  ? 24.99500 -21.23600 46.93800 1.000 23.18566 ? 8   ASP A CG  1 
ATOM   41   O  OD1 . ASP A 1 14  ? 24.09700 -21.53400 46.14300 1.000 23.86941 ? 8   ASP A OD1 1 
ATOM   42   O  OD2 . ASP A 1 14  ? 25.99400 -20.55400 46.64500 1.000 21.36775 ? 8   ASP A OD2 1 
ATOM   43   N  N   . PRO A 1 15  ? 23.08200 -23.05500 50.58100 1.000 22.28820 ? 9   PRO A N   1 
ATOM   44   C  CA  . PRO A 1 15  ? 22.80300 -23.43700 51.97200 1.000 27.78567 ? 9   PRO A CA  1 
ATOM   45   C  C   . PRO A 1 15  ? 23.90000 -22.98700 52.91900 1.000 27.96252 ? 9   PRO A C   1 
ATOM   46   O  O   . PRO A 1 15  ? 25.08100 -22.90100 52.56000 1.000 24.07960 ? 9   PRO A O   1 
ATOM   47   C  CB  . PRO A 1 15  ? 22.71500 -24.96800 51.92000 1.000 22.02083 ? 9   PRO A CB  1 
ATOM   48   C  CG  . PRO A 1 15  ? 22.40900 -25.29200 50.49300 1.000 21.76879 ? 9   PRO A CG  1 
ATOM   49   C  CD  . PRO A 1 15  ? 23.16400 -24.23300 49.70600 1.000 18.66417 ? 9   PRO A CD  1 
ATOM   50   N  N   . SER A 1 16  ? 23.49600 -22.69200 54.14100 1.000 29.76171 ? 10  SER A N   1 
ATOM   51   C  CA  . SER A 1 16  ? 24.46200 -22.39600 55.18000 1.000 31.64244 ? 10  SER A CA  1 
ATOM   52   C  C   . SER A 1 16  ? 24.72400 -23.64900 56.02100 1.000 32.76528 ? 10  SER A C   1 
ATOM   53   O  O   . SER A 1 16  ? 23.93100 -24.59900 56.00100 1.000 32.50085 ? 10  SER A O   1 
ATOM   54   C  CB  . SER A 1 16  ? 23.94300 -21.23800 56.04300 1.000 36.12440 ? 10  SER A CB  1 
ATOM   55   O  OG  . SER A 1 16  ? 22.85800 -21.67100 56.83000 1.000 48.31763 ? 10  SER A OG  1 
ATOM   56   N  N   . PRO A 1 17  ? 25.85400 -23.71400 56.74100 1.000 30.75185 ? 11  PRO A N   1 
ATOM   57   C  CA  . PRO A 1 17  ? 26.21200 -24.96400 57.40900 1.000 30.87645 ? 11  PRO A CA  1 
ATOM   58   C  C   . PRO A 1 17  ? 25.27900 -25.22900 58.57700 1.000 34.36648 ? 11  PRO A C   1 
ATOM   59   O  O   . PRO A 1 17  ? 24.76000 -24.28600 59.19600 1.000 30.76382 ? 11  PRO A O   1 
ATOM   60   C  CB  . PRO A 1 17  ? 27.65500 -24.71200 57.88500 1.000 32.19337 ? 11  PRO A CB  1 
ATOM   61   C  CG  . PRO A 1 17  ? 27.74500 -23.25200 58.06600 1.000 29.47338 ? 11  PRO A CG  1 
ATOM   62   C  CD  . PRO A 1 17  ? 26.84200 -22.64800 57.00300 1.000 28.92265 ? 11  PRO A CD  1 
ATOM   63   N  N   . PRO A 1 18  ? 25.00900 -26.50500 58.89800 1.000 35.43749 ? 12  PRO A N   1 
ATOM   64   C  CA  . PRO A 1 18  ? 24.09300 -26.85800 60.00000 1.000 37.61444 ? 12  PRO A CA  1 
ATOM   65   C  C   . PRO A 1 18  ? 24.65600 -26.47800 61.36400 1.000 37.60531 ? 12  PRO A C   1 
ATOM   66   O  O   . PRO A 1 18  ? 25.88600 -26.51200 61.48200 1.000 43.27156 ? 12  PRO A O   1 
ATOM   67   C  CB  . PRO A 1 18  ? 23.95700 -28.38400 59.88100 1.000 37.68453 ? 12  PRO A CB  1 
ATOM   68   C  CG  . PRO A 1 18  ? 25.21100 -28.82900 59.18100 1.000 36.63933 ? 12  PRO A CG  1 
ATOM   69   C  CD  . PRO A 1 18  ? 25.59500 -27.69300 58.24900 1.000 33.05837 ? 12  PRO A CD  1 
ATOM   70   N  N   . ASP A 1 21  ? 29.47300 -25.60700 63.69800 1.000 65.13722 ? 15  ASP A N   1 
ATOM   71   C  CA  . ASP A 1 21  ? 30.12700 -24.92700 64.81400 1.000 57.23813 ? 15  ASP A CA  1 
ATOM   72   C  C   . ASP A 1 21  ? 31.56700 -24.54400 64.44100 1.000 57.50007 ? 15  ASP A C   1 
ATOM   73   O  O   . ASP A 1 21  ? 32.14100 -25.07600 63.48300 1.000 57.10894 ? 15  ASP A O   1 
ATOM   74   C  CB  . ASP A 1 21  ? 30.10100 -25.80900 66.07000 1.000 58.23344 ? 15  ASP A CB  1 
ATOM   75   N  N   . THR A 1 22  ? 32.13600 -23.60200 65.18700 1.000 56.43245 ? 16  THR A N   1 
ATOM   76   C  CA  . THR A 1 22  ? 33.48300 -23.12600 64.90500 1.000 56.54034 ? 16  THR A CA  1 
ATOM   77   C  C   . THR A 1 22  ? 34.49900 -24.23800 65.16000 1.000 51.03049 ? 16  THR A C   1 
ATOM   78   O  O   . THR A 1 22  ? 34.25900 -25.16400 65.94200 1.000 58.64738 ? 16  THR A O   1 
ATOM   79   C  CB  . THR A 1 22  ? 33.79800 -21.88900 65.76400 1.000 64.63159 ? 16  THR A CB  1 
ATOM   80   O  OG1 . THR A 1 22  ? 32.70800 -20.96200 65.68600 1.000 66.06408 ? 16  THR A OG1 1 
ATOM   81   C  CG2 . THR A 1 22  ? 35.06400 -21.17400 65.29100 1.000 58.10348 ? 16  THR A CG2 1 
ATOM   82   N  N   . ASN A 1 23  ? 35.63100 -24.15200 64.45400 1.000 50.94797 ? 17  ASN A N   1 
ATOM   83   C  CA  . ASN A 1 23  ? 36.75700 -25.08400 64.54900 1.000 56.27502 ? 17  ASN A CA  1 
ATOM   84   C  C   . ASN A 1 23  ? 36.48400 -26.43000 63.87400 1.000 51.91537 ? 17  ASN A C   1 
ATOM   85   O  O   . ASN A 1 23  ? 37.43100 -27.11900 63.47800 1.000 52.79019 ? 17  ASN A O   1 
ATOM   86   C  CB  . ASN A 1 23  ? 37.18500 -25.29900 66.00900 1.000 52.26733 ? 17  ASN A CB  1 
ATOM   87   C  CG  . ASN A 1 23  ? 37.76300 -24.03200 66.64500 1.000 62.41909 ? 17  ASN A CG  1 
ATOM   88   O  OD1 . ASN A 1 23  ? 38.72900 -23.45100 66.13300 1.000 56.09129 ? 17  ASN A OD1 1 
ATOM   89   N  ND2 . ASN A 1 23  ? 37.18500 -23.61000 67.77100 1.000 48.68416 ? 17  ASN A ND2 1 
ATOM   90   N  N   . LYS A 1 24  ? 35.21500 -26.82200 63.75200 1.000 42.36630 ? 18  LYS A N   1 
ATOM   91   C  CA  . LYS A 1 24  ? 34.83900 -27.95500 62.91000 1.000 36.80448 ? 18  LYS A CA  1 
ATOM   92   C  C   . LYS A 1 24  ? 35.40700 -27.77900 61.50200 1.000 33.74742 ? 18  LYS A C   1 
ATOM   93   O  O   . LYS A 1 24  ? 35.25900 -26.71800 60.89600 1.000 34.31781 ? 18  LYS A O   1 
ATOM   94   C  CB  . LYS A 1 24  ? 33.31200 -28.03700 62.85600 1.000 43.48314 ? 18  LYS A CB  1 
ATOM   95   C  CG  . LYS A 1 24  ? 32.69400 -29.40100 63.03100 1.000 42.05655 ? 18  LYS A CG  1 
ATOM   96   C  CD  . LYS A 1 24  ? 31.17500 -29.27000 62.97600 1.000 39.28891 ? 18  LYS A CD  1 
ATOM   97   C  CE  . LYS A 1 24  ? 30.49400 -30.60100 62.72500 1.000 37.53516 ? 18  LYS A CE  1 
ATOM   98   N  NZ  . LYS A 1 24  ? 31.27100 -31.71700 63.33000 1.000 41.89377 ? 18  LYS A NZ  1 
ATOM   99   N  N   . LEU A 1 25  ? 36.06000 -28.81800 60.97700 1.000 29.53176 ? 19  LEU A N   1 
ATOM   100  C  CA  . LEU A 1 25  ? 36.59700 -28.71700 59.62300 1.000 30.60568 ? 19  LEU A CA  1 
ATOM   101  C  C   . LEU A 1 25  ? 35.61200 -29.17400 58.55200 1.000 30.86954 ? 19  LEU A C   1 
ATOM   102  O  O   . LEU A 1 25  ? 35.78100 -28.80500 57.37800 1.000 27.04750 ? 19  LEU A O   1 
ATOM   103  C  CB  . LEU A 1 25  ? 37.89200 -29.51700 59.49900 1.000 25.83419 ? 19  LEU A CB  1 
ATOM   104  C  CG  . LEU A 1 25  ? 38.98200 -29.14300 60.51900 1.000 34.66430 ? 19  LEU A CG  1 
ATOM   105  C  CD1 . LEU A 1 25  ? 40.24800 -29.90800 60.22000 1.000 30.32382 ? 19  LEU A CD1 1 
ATOM   106  C  CD2 . LEU A 1 25  ? 39.25400 -27.63400 60.53600 1.000 26.99026 ? 19  LEU A CD2 1 
ATOM   107  N  N   . ASN A 1 26  ? 34.58900 -29.94700 58.92900 1.000 26.91063 ? 20  ASN A N   1 
ATOM   108  C  CA  . ASN A 1 26  ? 33.57700 -30.43900 57.99600 1.000 26.06909 ? 20  ASN A CA  1 
ATOM   109  C  C   . ASN A 1 26  ? 32.25100 -29.73200 58.23800 1.000 23.92058 ? 20  ASN A C   1 
ATOM   110  O  O   . ASN A 1 26  ? 31.22500 -30.37800 58.47200 1.000 26.62018 ? 20  ASN A O   1 
ATOM   111  C  CB  . ASN A 1 26  ? 33.40600 -31.95800 58.13400 1.000 25.35454 ? 20  ASN A CB  1 
ATOM   112  C  CG  . ASN A 1 26  ? 32.99600 -32.37700 59.54500 1.000 30.72956 ? 20  ASN A CG  1 
ATOM   113  O  OD1 . ASN A 1 26  ? 33.21300 -31.64200 60.50300 1.000 30.69160 ? 20  ASN A OD1 1 
ATOM   114  N  ND2 . ASN A 1 26  ? 32.39400 -33.55800 59.66900 1.000 28.00922 ? 20  ASN A ND2 1 
ATOM   115  N  N   . LYS A 1 27  ? 32.26100 -28.40200 58.15200 1.000 26.45535 ? 21  LYS A N   1 
ATOM   116  C  CA  . LYS A 1 27  ? 31.08800 -27.61600 58.51200 1.000 23.08981 ? 21  LYS A CA  1 
ATOM   117  C  C   . LYS A 1 27  ? 29.88100 -27.96400 57.65400 1.000 25.57989 ? 21  LYS A C   1 
ATOM   118  O  O   . LYS A 1 27  ? 28.74300 -27.94100 58.14300 1.000 25.40979 ? 21  LYS A O   1 
ATOM   119  C  CB  . LYS A 1 27  ? 31.40700 -26.12300 58.40400 1.000 25.47248 ? 21  LYS A CB  1 
ATOM   120  C  CG  . LYS A 1 27  ? 32.33800 -25.60200 59.49100 1.000 27.33401 ? 21  LYS A CG  1 
ATOM   121  C  CD  . LYS A 1 27  ? 32.58200 -24.09100 59.32600 1.000 25.77757 ? 21  LYS A CD  1 
ATOM   122  C  CE  . LYS A 1 27  ? 33.34400 -23.50800 60.51800 1.000 30.58369 ? 21  LYS A CE  1 
ATOM   123  N  NZ  . LYS A 1 27  ? 34.76100 -24.03300 60.61800 1.000 36.03201 ? 21  LYS A NZ  1 
ATOM   124  N  N   . TYR A 1 28  ? 30.09400 -28.27100 56.36800 1.000 21.91538 ? 22  TYR A N   1 
ATOM   125  C  CA  . TYR A 1 28  ? 28.96700 -28.56000 55.48800 1.000 24.06022 ? 22  TYR A CA  1 
ATOM   126  C  C   . TYR A 1 28  ? 28.69300 -30.05100 55.36900 1.000 19.17043 ? 22  TYR A C   1 
ATOM   127  O  O   . TYR A 1 28  ? 27.53300 -30.45600 55.44700 1.000 20.85452 ? 22  TYR A O   1 
ATOM   128  C  CB  . TYR A 1 28  ? 29.18400 -27.94800 54.08600 1.000 21.48865 ? 22  TYR A CB  1 
ATOM   129  C  CG  . TYR A 1 28  ? 29.09100 -26.43800 54.11200 1.000 17.98504 ? 22  TYR A CG  1 
ATOM   130  C  CD1 . TYR A 1 28  ? 30.19700 -25.67000 54.39300 1.000 20.37740 ? 22  TYR A CD1 1 
ATOM   131  C  CD2 . TYR A 1 28  ? 27.87600 -25.78700 53.88900 1.000 23.58021 ? 22  TYR A CD2 1 
ATOM   132  C  CE1 . TYR A 1 28  ? 30.11000 -24.26600 54.43000 1.000 19.87287 ? 22  TYR A CE1 1 
ATOM   133  C  CE2 . TYR A 1 28  ? 27.78200 -24.39200 53.92600 1.000 23.37531 ? 22  TYR A CE2 1 
ATOM   134  C  CZ  . TYR A 1 28  ? 28.90000 -23.64600 54.19800 1.000 22.85005 ? 22  TYR A CZ  1 
ATOM   135  O  OH  . TYR A 1 28  ? 28.82100 -22.25600 54.23400 1.000 24.48400 ? 22  TYR A OH  1 
ATOM   136  N  N   . SER A 1 29  ? 29.73200 -30.87500 55.18700 1.000 19.40616 ? 23  SER A N   1 
ATOM   137  C  CA  . SER A 1 29  ? 29.48200 -32.29000 54.93500 1.000 21.76585 ? 23  SER A CA  1 
ATOM   138  C  C   . SER A 1 29  ? 28.95100 -33.01100 56.16800 1.000 25.65127 ? 23  SER A C   1 
ATOM   139  O  O   . SER A 1 29  ? 28.29700 -34.04600 56.01700 1.000 22.72310 ? 23  SER A O   1 
ATOM   140  C  CB  . SER A 1 29  ? 30.73800 -32.99400 54.38800 1.000 24.10788 ? 23  SER A CB  1 
ATOM   141  O  OG  . SER A 1 29  ? 31.87000 -32.91100 55.21900 1.000 22.25891 ? 23  SER A OG  1 
ATOM   142  N  N   . SER A 1 30  ? 29.20100 -32.48200 57.37600 1.000 24.84939 ? 24  SER A N   1 
ATOM   143  C  CA  . SER A 1 30  ? 28.56400 -33.01900 58.57300 1.000 26.38848 ? 24  SER A CA  1 
ATOM   144  C  C   . SER A 1 30  ? 27.05100 -33.05400 58.44800 1.000 28.39286 ? 24  SER A C   1 
ATOM   145  O  O   . SER A 1 30  ? 26.41000 -33.85400 59.13900 1.000 27.29610 ? 24  SER A O   1 
ATOM   146  C  CB  . SER A 1 30  ? 28.94900 -32.18800 59.80200 1.000 25.66882 ? 24  SER A CB  1 
ATOM   147  O  OG  . SER A 1 30  ? 28.52100 -30.83700 59.65000 1.000 26.63761 ? 24  SER A OG  1 
ATOM   148  N  N   . ARG A 1 31  ? 26.46900 -32.19100 57.60200 1.000 25.15818 ? 25  ARG A N   1 
ATOM   149  C  CA  . ARG A 1 31  ? 25.03100 -32.22700 57.37000 1.000 25.88963 ? 25  ARG A CA  1 
ATOM   150  C  C   . ARG A 1 31  ? 24.58000 -33.60600 56.91500 1.000 23.38622 ? 25  ARG A C   1 
ATOM   151  O  O   . ARG A 1 31  ? 23.47700 -34.04600 57.25600 1.000 25.30503 ? 25  ARG A O   1 
ATOM   152  C  CB  . ARG A 1 31  ? 24.63000 -31.17500 56.32400 1.000 24.18862 ? 25  ARG A CB  1 
ATOM   153  C  CG  . ARG A 1 31  ? 23.15600 -31.21700 55.93100 1.000 23.81714 ? 25  ARG A CG  1 
ATOM   154  C  CD  . ARG A 1 31  ? 22.28800 -30.69400 57.07300 1.000 26.65670 ? 25  ARG A CD  1 
ATOM   155  N  NE  . ARG A 1 31  ? 20.85900 -30.76400 56.78500 1.000 27.01157 ? 25  ARG A NE  1 
ATOM   156  C  CZ  . ARG A 1 31  ? 20.09600 -31.80900 57.06100 1.000 30.27972 ? 25  ARG A CZ  1 
ATOM   157  N  NH1 . ARG A 1 31  ? 20.61100 -32.93100 57.53700 1.000 27.08551 ? 25  ARG A NH1 1 
ATOM   158  N  NH2 . ARG A 1 31  ? 18.78400 -31.72600 56.86500 1.000 34.44583 ? 25  ARG A NH2 1 
ATOM   159  N  N   . ILE A 1 32  ? 25.40400 -34.30700 56.15000 1.000 22.50970 ? 26  ILE A N   1 
ATOM   160  C  CA  . ILE A 1 32  ? 24.99000 -35.59800 55.62300 1.000 26.33405 ? 26  ILE A CA  1 
ATOM   161  C  C   . ILE A 1 32  ? 25.78800 -36.75800 56.20900 1.000 24.95244 ? 26  ILE A C   1 
ATOM   162  O  O   . ILE A 1 32  ? 25.31200 -37.89900 56.14000 1.000 24.07977 ? 26  ILE A O   1 
ATOM   163  C  CB  . ILE A 1 32  ? 25.05200 -35.63200 54.07900 1.000 24.11650 ? 26  ILE A CB  1 
ATOM   164  C  CG1 . ILE A 1 32  ? 26.45500 -35.27200 53.59100 1.000 24.17109 ? 26  ILE A CG1 1 
ATOM   165  C  CG2 . ILE A 1 32  ? 23.97900 -34.69100 53.45700 1.000 23.22392 ? 26  ILE A CG2 1 
ATOM   166  C  CD1 . ILE A 1 32  ? 26.62500 -35.47500 52.08100 1.000 28.83544 ? 26  ILE A CD1 1 
ATOM   167  N  N   . THR A 1 33  ? 26.97200 -36.51400 56.77800 1.000 28.05048 ? 27  THR A N   1 
ATOM   168  C  CA  . THR A 1 33  ? 27.77700 -37.61700 57.29700 1.000 29.03299 ? 27  THR A CA  1 
ATOM   169  C  C   . THR A 1 33  ? 27.47400 -37.94900 58.75400 1.000 29.74520 ? 27  THR A C   1 
ATOM   170  O  O   . THR A 1 33  ? 27.82900 -39.04500 59.20400 1.000 31.00915 ? 27  THR A O   1 
ATOM   171  C  CB  . THR A 1 33  ? 29.29100 -37.33500 57.16200 1.000 24.90438 ? 27  THR A CB  1 
ATOM   172  O  OG1 . THR A 1 33  ? 29.65100 -36.14500 57.87800 1.000 29.17599 ? 27  THR A OG1 1 
ATOM   173  C  CG2 . THR A 1 33  ? 29.71700 -37.21500 55.69500 1.000 23.99904 ? 27  THR A CG2 1 
ATOM   174  N  N   . GLU A 1 34  ? 26.82300 -37.04900 59.49200 1.000 29.14104 ? 28  GLU A N   1 
ATOM   175  C  CA  . GLU A 1 34  ? 26.67100 -37.20900 60.94300 1.000 32.41055 ? 28  GLU A CA  1 
ATOM   176  C  C   . GLU A 1 34  ? 25.26300 -37.58100 61.42100 1.000 35.37056 ? 28  GLU A C   1 
ATOM   177  O  O   . GLU A 1 34  ? 25.14900 -38.40500 62.33800 1.000 36.73820 ? 28  GLU A O   1 
ATOM   178  C  CB  . GLU A 1 34  ? 27.13800 -35.93800 61.65900 1.000 29.34185 ? 28  GLU A CB  1 
ATOM   179  C  CG  . GLU A 1 34  ? 28.66200 -35.85500 61.80300 1.000 35.86946 ? 28  GLU A CG  1 
ATOM   180  C  CD  . GLU A 1 34  ? 29.16100 -34.53500 62.38700 1.000 37.80602 ? 28  GLU A CD  1 
ATOM   181  O  OE1 . GLU A 1 34  ? 28.35300 -33.77800 62.97700 1.000 34.50908 ? 28  GLU A OE1 1 
ATOM   182  O  OE2 . GLU A 1 34  ? 30.37600 -34.25800 62.24400 1.000 36.51939 ? 28  GLU A OE2 1 
ATOM   183  N  N   . PRO A 1 35  ? 24.16900 -37.01500 60.88700 1.000 34.30306 ? 29  PRO A N   1 
ATOM   184  C  CA  . PRO A 1 35  ? 22.84800 -37.37700 61.42800 1.000 37.01799 ? 29  PRO A CA  1 
ATOM   185  C  C   . PRO A 1 35  ? 22.44900 -38.78200 61.02200 1.000 34.29859 ? 29  PRO A C   1 
ATOM   186  O  O   . PRO A 1 35  ? 22.61100 -39.18400 59.86700 1.000 33.14609 ? 29  PRO A O   1 
ATOM   187  C  CB  . PRO A 1 35  ? 21.89300 -36.33800 60.81400 1.000 37.59408 ? 29  PRO A CB  1 
ATOM   188  C  CG  . PRO A 1 35  ? 22.77200 -35.27600 60.23300 1.000 33.70270 ? 29  PRO A CG  1 
ATOM   189  C  CD  . PRO A 1 35  ? 24.04500 -35.96700 59.85800 1.000 29.02491 ? 29  PRO A CD  1 
ATOM   190  N  N   . LYS A 1 36  ? 21.91200 -39.53100 61.99100 1.000 33.25356 ? 30  LYS A N   1 
ATOM   191  C  CA  . LYS A 1 36  ? 21.36000 -40.84600 61.67900 1.000 36.87541 ? 30  LYS A CA  1 
ATOM   192  C  C   . LYS A 1 36  ? 20.22800 -40.74000 60.66700 1.000 34.23488 ? 30  LYS A C   1 
ATOM   193  O  O   . LYS A 1 36  ? 19.98700 -41.67900 59.90000 1.000 36.25274 ? 30  LYS A O   1 
ATOM   194  C  CB  . LYS A 1 36  ? 20.87200 -41.53200 62.95600 1.000 42.98270 ? 30  LYS A CB  1 
ATOM   195  C  CG  . LYS A 1 36  ? 21.98000 -41.97800 63.88200 1.000 45.59165 ? 30  LYS A CG  1 
ATOM   196  C  CD  . LYS A 1 36  ? 21.40700 -42.44000 65.21300 1.000 59.51313 ? 30  LYS A CD  1 
ATOM   197  C  CE  . LYS A 1 36  ? 22.50700 -42.90400 66.15500 1.000 60.64665 ? 30  LYS A CE  1 
ATOM   198  N  NZ  . LYS A 1 36  ? 22.21100 -44.25000 66.70000 1.000 67.43429 ? 30  LYS A NZ  1 
ATOM   199  N  N   . SER A 1 37  ? 19.54400 -39.59600 60.63100 1.000 31.65155 ? 31  SER A N   1 
ATOM   200  C  CA  . SER A 1 37  ? 18.46600 -39.37800 59.68100 1.000 30.49984 ? 31  SER A CA  1 
ATOM   201  C  C   . SER A 1 37  ? 18.96000 -39.24800 58.24000 1.000 31.70424 ? 31  SER A C   1 
ATOM   202  O  O   . SER A 1 37  ? 18.13700 -39.20500 57.32300 1.000 31.57525 ? 31  SER A O   1 
ATOM   203  C  CB  . SER A 1 37  ? 17.68200 -38.13000 60.08300 1.000 32.46747 ? 31  SER A CB  1 
ATOM   204  O  OG  . SER A 1 37  ? 18.53000 -36.99900 60.06800 1.000 34.98483 ? 31  SER A OG  1 
ATOM   205  N  N   . GLN A 1 38  ? 20.27100 -39.16700 58.01800 1.000 29.17455 ? 32  GLN A N   1 
ATOM   206  C  CA  . GLN A 1 38  ? 20.83900 -39.11900 56.67500 1.000 33.75480 ? 32  GLN A CA  1 
ATOM   207  C  C   . GLN A 1 38  ? 21.59000 -40.40900 56.33900 1.000 31.10020 ? 32  GLN A C   1 
ATOM   208  O  O   . GLN A 1 38  ? 22.60100 -40.38500 55.63500 1.000 30.84370 ? 32  GLN A O   1 
ATOM   209  C  CB  . GLN A 1 38  ? 21.74600 -37.89300 56.52600 1.000 27.47990 ? 32  GLN A CB  1 
ATOM   210  C  CG  . GLN A 1 38  ? 21.01000 -36.55700 56.58800 1.000 28.88115 ? 32  GLN A CG  1 
ATOM   211  C  CD  . GLN A 1 38  ? 20.00600 -36.34600 55.45000 1.000 34.04744 ? 32  GLN A CD  1 
ATOM   212  O  OE1 . GLN A 1 38  ? 20.23900 -36.73800 54.29000 1.000 34.80686 ? 32  GLN A OE1 1 
ATOM   213  N  NE2 . GLN A 1 38  ? 18.89200 -35.70000 55.77300 1.000 28.40906 ? 32  GLN A NE2 1 
ATOM   214  N  N   . GLY A 1 39  ? 21.10600 -41.54900 56.85000 1.000 31.61005 ? 33  GLY A N   1 
ATOM   215  C  CA  . GLY A 1 39  ? 21.74900 -42.82000 56.54600 1.000 36.00034 ? 33  GLY A CA  1 
ATOM   216  C  C   . GLY A 1 39  ? 21.77600 -43.14600 55.06100 1.000 36.38335 ? 33  GLY A C   1 
ATOM   217  O  O   . GLY A 1 39  ? 22.72500 -43.77800 54.57200 1.000 31.89678 ? 33  GLY A O   1 
ATOM   218  N  N   . GLY A 1 40  ? 20.75100 -42.71800 54.32200 1.000 29.00899 ? 34  GLY A N   1 
ATOM   219  C  CA  . GLY A 1 40  ? 20.78200 -42.89900 52.87700 1.000 33.31494 ? 34  GLY A CA  1 
ATOM   220  C  C   . GLY A 1 40  ? 21.98700 -42.23100 52.23900 1.000 32.33066 ? 34  GLY A C   1 
ATOM   221  O  O   . GLY A 1 40  ? 22.67900 -42.83200 51.41400 1.000 32.86912 ? 34  GLY A O   1 
ATOM   222  N  N   . SER A 1 41  ? 22.25000 -40.96800 52.61700 1.000 31.93040 ? 35  SER A N   1 
ATOM   223  C  CA  . SER A 1 41  ? 23.44500 -40.26400 52.15100 1.000 27.71263 ? 35  SER A CA  1 
ATOM   224  C  C   . SER A 1 41  ? 24.70900 -41.03900 52.50600 1.000 32.63669 ? 35  SER A C   1 
ATOM   225  O  O   . SER A 1 41  ? 25.59000 -41.25400 51.66000 1.000 31.55731 ? 35  SER A O   1 
ATOM   226  C  CB  . SER A 1 41  ? 23.49400 -38.85900 52.76000 1.000 25.36940 ? 35  SER A CB  1 
ATOM   227  O  OG  . SER A 1 41  ? 22.22600 -38.21900 52.67700 1.000 30.04542 ? 35  SER A OG  1 
ATOM   228  N  N   . GLN A 1 42  ? 24.80400 -41.49700 53.75300 1.000 27.18540 ? 36  GLN A N   1 
ATOM   229  C  CA  . GLN A 1 42  ? 25.99500 -42.23300 54.16000 1.000 33.42174 ? 36  GLN A CA  1 
ATOM   230  C  C   . GLN A 1 42  ? 26.15000 -43.55000 53.39600 1.000 32.57037 ? 36  GLN A C   1 
ATOM   231  O  O   . GLN A 1 42  ? 27.28000 -43.98300 53.14000 1.000 28.00646 ? 36  GLN A O   1 
ATOM   232  C  CB  . GLN A 1 42  ? 25.96300 -42.48200 55.66600 1.000 31.93494 ? 36  GLN A CB  1 
ATOM   233  C  CG  . GLN A 1 42  ? 26.07900 -41.21600 56.48100 1.000 34.15702 ? 36  GLN A CG  1 
ATOM   234  C  CD  . GLN A 1 42  ? 25.21300 -41.27000 57.71900 1.000 34.89630 ? 36  GLN A CD  1 
ATOM   235  O  OE1 . GLN A 1 42  ? 25.00400 -42.34200 58.27100 1.000 39.40180 ? 36  GLN A OE1 1 
ATOM   236  N  NE2 . GLN A 1 42  ? 24.70400 -40.12000 58.15900 1.000 31.59628 ? 36  GLN A NE2 1 
ATOM   237  N  N   . ALA A 1 43  ? 25.04000 -44.19600 53.01500 1.000 28.60296 ? 37  ALA A N   1 
ATOM   238  C  CA  . ALA A 1 43  ? 25.16200 -45.44100 52.26000 1.000 34.30780 ? 37  ALA A CA  1 
ATOM   239  C  C   . ALA A 1 43  ? 25.73300 -45.18800 50.87000 1.000 32.36971 ? 37  ALA A C   1 
ATOM   240  O  O   . ALA A 1 43  ? 26.57300 -45.96400 50.38700 1.000 31.38711 ? 37  ALA A O   1 
ATOM   241  C  CB  . ALA A 1 43  ? 23.80700 -46.14200 52.16500 1.000 35.82148 ? 37  ALA A CB  1 
ATOM   242  N  N   . ILE A 1 44  ? 25.28000 -44.11900 50.20200 1.000 28.95299 ? 38  ILE A N   1 
ATOM   243  C  CA  . ILE A 1 44  ? 25.88700 -43.73400 48.93000 1.000 33.53569 ? 38  ILE A CA  1 
ATOM   244  C  C   . ILE A 1 44  ? 27.38300 -43.49800 49.11000 1.000 28.52762 ? 38  ILE A C   1 
ATOM   245  O  O   . ILE A 1 44  ? 28.20800 -43.96700 48.31000 1.000 24.22276 ? 38  ILE A O   1 
ATOM   246  C  CB  . ILE A 1 44  ? 25.19800 -42.48600 48.34300 1.000 25.68060 ? 38  ILE A CB  1 
ATOM   247  C  CG1 . ILE A 1 44  ? 23.74800 -42.79900 47.98400 1.000 28.36038 ? 38  ILE A CG1 1 
ATOM   248  C  CG2 . ILE A 1 44  ? 25.92400 -42.05600 47.08100 1.000 26.15384 ? 38  ILE A CG2 1 
ATOM   249  C  CD1 . ILE A 1 44  ? 23.59400 -43.74900 46.80600 1.000 32.50406 ? 38  ILE A CD1 1 
ATOM   250  N  N   . LEU A 1 45  ? 27.75000 -42.76600 50.16900 1.000 27.52156 ? 39  LEU A N   1 
ATOM   251  C  CA  . LEU A 1 45  ? 29.15400 -42.40500 50.37700 1.000 30.78050 ? 39  LEU A CA  1 
ATOM   252  C  C   . LEU A 1 45  ? 30.01700 -43.64000 50.63100 1.000 28.90973 ? 39  LEU A C   1 
ATOM   253  O  O   . LEU A 1 45  ? 31.14300 -43.73000 50.12800 1.000 28.12068 ? 39  LEU A O   1 
ATOM   254  C  CB  . LEU A 1 45  ? 29.27700 -41.40400 51.53000 1.000 27.18227 ? 39  LEU A CB  1 
ATOM   255  C  CG  . LEU A 1 45  ? 28.77500 -39.96900 51.23200 1.000 26.40099 ? 39  LEU A CG  1 
ATOM   256  C  CD1 . LEU A 1 45  ? 28.76600 -39.11000 52.48600 1.000 25.04255 ? 39  LEU A CD1 1 
ATOM   257  C  CD2 . LEU A 1 45  ? 29.59000 -39.27800 50.11700 1.000 24.83268 ? 39  LEU A CD2 1 
ATOM   258  N  N   . HIS A 1 46  ? 29.51200 -44.59900 51.41700 1.000 34.92892 ? 40  HIS A N   1 
ATOM   259  C  CA  . HIS A 1 46  ? 30.19900 -45.88700 51.53300 1.000 33.66452 ? 40  HIS A CA  1 
ATOM   260  C  C   . HIS A 1 46  ? 30.33700 -46.54200 50.17000 1.000 32.99366 ? 40  HIS A C   1 
ATOM   261  O  O   . HIS A 1 46  ? 31.40000 -47.07200 49.82800 1.000 34.63548 ? 40  HIS A O   1 
ATOM   262  C  CB  . HIS A 1 46  ? 29.44400 -46.82200 52.48700 1.000 32.01663 ? 40  HIS A CB  1 
ATOM   263  C  CG  . HIS A 1 46  ? 29.56600 -46.43900 53.93100 1.000 36.25433 ? 40  HIS A CG  1 
ATOM   264  N  ND1 . HIS A 1 46  ? 30.78100 -46.17700 54.53100 1.000 41.03326 ? 40  HIS A ND1 1 
ATOM   265  C  CD2 . HIS A 1 46  ? 28.62800 -46.27700 54.89600 1.000 34.99086 ? 40  HIS A CD2 1 
ATOM   266  C  CE1 . HIS A 1 46  ? 30.58700 -45.87500 55.80400 1.000 35.49525 ? 40  HIS A CE1 1 
ATOM   267  N  NE2 . HIS A 1 46  ? 29.28900 -45.92800 56.04900 1.000 40.48701 ? 40  HIS A NE2 1 
ATOM   268  N  N   . GLY A 1 47  ? 29.26400 -46.50000 49.36900 1.000 31.77187 ? 41  GLY A N   1 
ATOM   269  C  CA  . GLY A 1 47  ? 29.29700 -47.11300 48.05600 1.000 31.60442 ? 41  GLY A CA  1 
ATOM   270  C  C   . GLY A 1 47  ? 30.34800 -46.53000 47.13400 1.000 32.42293 ? 41  GLY A C   1 
ATOM   271  O  O   . GLY A 1 47  ? 30.88800 -47.24100 46.28800 1.000 28.02246 ? 41  GLY A O   1 
ATOM   272  N  N   . VAL A 1 48  ? 30.63900 -45.22600 47.25600 1.000 29.42177 ? 42  VAL A N   1 
ATOM   273  C  CA  . VAL A 1 48  ? 31.68600 -44.63100 46.42900 1.000 29.25089 ? 42  VAL A CA  1 
ATOM   274  C  C   . VAL A 1 48  ? 33.05800 -44.78200 47.07100 1.000 35.57921 ? 42  VAL A C   1 
ATOM   275  O  O   . VAL A 1 48  ? 34.05100 -44.29300 46.51500 1.000 33.64461 ? 42  VAL A O   1 
ATOM   276  C  CB  . VAL A 1 48  ? 31.41600 -43.14300 46.09300 1.000 35.03478 ? 42  VAL A CB  1 
ATOM   277  C  CG1 . VAL A 1 48  ? 29.96800 -42.94000 45.58400 1.000 31.82862 ? 42  VAL A CG1 1 
ATOM   278  C  CG2 . VAL A 1 48  ? 31.71400 -42.23600 47.28500 1.000 31.56837 ? 42  VAL A CG2 1 
ATOM   279  N  N   . GLY A 1 49  ? 33.14500 -45.44900 48.22200 1.000 33.13643 ? 43  GLY A N   1 
ATOM   280  C  CA  . GLY A 1 49  ? 34.43200 -45.84800 48.75200 1.000 34.11918 ? 43  GLY A CA  1 
ATOM   281  C  C   . GLY A 1 49  ? 34.81800 -45.26400 50.09600 1.000 34.35832 ? 43  GLY A C   1 
ATOM   282  O  O   . GLY A 1 49  ? 35.94500 -45.47700 50.54100 1.000 33.61498 ? 43  GLY A O   1 
ATOM   283  N  N   . LEU A 1 50  ? 33.92500 -44.53000 50.75800 1.000 27.70202 ? 44  LEU A N   1 
ATOM   284  C  CA  . LEU A 1 50  ? 34.28500 -43.91300 52.02800 1.000 33.00054 ? 44  LEU A CA  1 
ATOM   285  C  C   . LEU A 1 50  ? 34.13700 -44.90700 53.17300 1.000 39.04714 ? 44  LEU A C   1 
ATOM   286  O  O   . LEU A 1 50  ? 33.11700 -45.60400 53.28700 1.000 31.63028 ? 44  LEU A O   1 
ATOM   287  C  CB  . LEU A 1 50  ? 33.43100 -42.67600 52.30700 1.000 30.82202 ? 44  LEU A CB  1 
ATOM   288  C  CG  . LEU A 1 50  ? 33.95000 -41.36300 51.70500 1.000 36.08932 ? 44  LEU A CG  1 
ATOM   289  C  CD1 . LEU A 1 50  ? 33.67000 -41.34700 50.23700 1.000 37.57825 ? 44  LEU A CD1 1 
ATOM   290  C  CD2 . LEU A 1 50  ? 33.31100 -40.16400 52.37900 1.000 32.96328 ? 44  LEU A CD2 1 
ATOM   291  N  N   . SER A 1 51  ? 35.15500 -44.95200 54.02600 1.000 35.30229 ? 45  SER A N   1 
ATOM   292  C  CA  . SER A 1 51  ? 35.09100 -45.70400 55.26700 1.000 38.77509 ? 45  SER A CA  1 
ATOM   293  C  C   . SER A 1 51  ? 34.36000 -44.89600 56.33200 1.000 39.36578 ? 45  SER A C   1 
ATOM   294  O  O   . SER A 1 51  ? 34.06200 -43.70900 56.15600 1.000 32.42172 ? 45  SER A O   1 
ATOM   295  C  CB  . SER A 1 51  ? 36.49500 -46.05100 55.75800 1.000 34.66152 ? 45  SER A CB  1 
ATOM   296  O  OG  . SER A 1 51  ? 37.16300 -44.89000 56.22500 1.000 37.98463 ? 45  SER A OG  1 
ATOM   297  N  N   . ASP A 1 52  ? 34.08500 -45.55100 57.46500 1.000 31.87952 ? 46  ASP A N   1 
ATOM   298  C  CA  . ASP A 1 52  ? 33.52900 -44.82700 58.60200 1.000 37.96125 ? 46  ASP A CA  1 
ATOM   299  C  C   . ASP A 1 52  ? 34.46100 -43.70500 59.03100 1.000 37.29153 ? 46  ASP A C   1 
ATOM   300  O  O   . ASP A 1 52  ? 34.00900 -42.59800 59.36000 1.000 36.75893 ? 46  ASP A O   1 
ATOM   301  C  CB  . ASP A 1 52  ? 33.25800 -45.78900 59.75900 1.000 39.09272 ? 46  ASP A CB  1 
ATOM   302  C  CG  . ASP A 1 52  ? 31.96900 -46.54700 59.57400 1.000 45.13049 ? 46  ASP A CG  1 
ATOM   303  O  OD1 . ASP A 1 52  ? 31.63000 -46.81800 58.40700 1.000 47.66188 ? 46  ASP A OD1 1 
ATOM   304  O  OD2 . ASP A 1 52  ? 31.29600 -46.87300 60.56900 1.000 53.66368 ? 46  ASP A OD2 1 
ATOM   305  N  N   . ASP A 1 53  ? 35.76800 -43.96600 59.02700 1.000 31.57751 ? 47  ASP A N   1 
ATOM   306  C  CA  A ASP A 1 53  ? 36.71100 -42.90700 59.36500 0.450 35.49975 ? 47  ASP A CA  1 
ATOM   307  C  CA  B ASP A 1 53  ? 36.72800 -42.91600 59.35000 0.550 35.50581 ? 47  ASP A CA  1 
ATOM   308  C  C   . ASP A 1 53  ? 36.68800 -41.79500 58.31500 1.000 32.58307 ? 47  ASP A C   1 
ATOM   309  O  O   . ASP A 1 53  ? 36.76500 -40.61200 58.66300 1.000 33.07866 ? 47  ASP A O   1 
ATOM   310  C  CB  A ASP A 1 53  ? 38.11700 -43.48600 59.52800 0.450 35.34153 ? 47  ASP A CB  1 
ATOM   311  C  CB  B ASP A 1 53  ? 38.13200 -43.50900 59.44500 0.550 35.33908 ? 47  ASP A CB  1 
ATOM   312  C  CG  A ASP A 1 53  ? 38.33700 -44.12800 60.89700 0.450 37.22884 ? 47  ASP A CG  1 
ATOM   313  C  CG  B ASP A 1 53  ? 39.12500 -42.54700 60.04800 0.550 34.62104 ? 47  ASP A CG  1 
ATOM   314  O  OD1 A ASP A 1 53  ? 37.41000 -44.10000 61.73800 0.450 34.42004 ? 47  ASP A OD1 1 
ATOM   315  O  OD1 B ASP A 1 53  ? 38.96500 -42.20800 61.23700 0.550 37.37097 ? 47  ASP A OD1 1 
ATOM   316  O  OD2 A ASP A 1 53  ? 39.44500 -44.65800 61.13100 0.450 37.61478 ? 47  ASP A OD2 1 
ATOM   317  O  OD2 B ASP A 1 53  ? 40.06500 -42.13500 59.33800 0.550 37.51436 ? 47  ASP A OD2 1 
ATOM   318  N  N   . ASP A 1 54  ? 36.56300 -42.15100 57.02900 1.000 31.18516 ? 48  ASP A N   1 
ATOM   319  C  CA  . ASP A 1 54  ? 36.48900 -41.13100 55.97600 1.000 35.20770 ? 48  ASP A CA  1 
ATOM   320  C  C   . ASP A 1 54  ? 35.31700 -40.17300 56.18300 1.000 30.12257 ? 48  ASP A C   1 
ATOM   321  O  O   . ASP A 1 54  ? 35.39400 -39.00400 55.78200 1.000 30.57246 ? 48  ASP A O   1 
ATOM   322  C  CB  . ASP A 1 54  ? 36.34400 -41.78000 54.59800 1.000 33.80519 ? 48  ASP A CB  1 
ATOM   323  C  CG  . ASP A 1 54  ? 37.59300 -42.49900 54.13400 1.000 32.55756 ? 48  ASP A CG  1 
ATOM   324  O  OD1 . ASP A 1 54  ? 38.71000 -42.13600 54.55400 1.000 30.43524 ? 48  ASP A OD1 1 
ATOM   325  O  OD2 . ASP A 1 54  ? 37.44100 -43.42200 53.30100 1.000 34.43785 ? 48  ASP A OD2 1 
ATOM   326  N  N   . LEU A 1 55  ? 34.22300 -40.64500 56.79200 1.000 30.27576 ? 49  LEU A N   1 
ATOM   327  C  CA  . LEU A 1 55  ? 33.03500 -39.81400 56.98100 1.000 28.57045 ? 49  LEU A CA  1 
ATOM   328  C  C   . LEU A 1 55  ? 33.27800 -38.66200 57.94500 1.000 30.55863 ? 49  LEU A C   1 
ATOM   329  O  O   . LEU A 1 55  ? 32.51900 -37.68300 57.93600 1.000 28.56970 ? 49  LEU A O   1 
ATOM   330  C  CB  . LEU A 1 55  ? 31.86500 -40.65700 57.49300 1.000 28.45833 ? 49  LEU A CB  1 
ATOM   331  C  CG  . LEU A 1 55  ? 31.22700 -41.69000 56.56000 1.000 31.87974 ? 49  LEU A CG  1 
ATOM   332  C  CD1 . LEU A 1 55  ? 30.09200 -42.41100 57.29000 1.000 31.77636 ? 49  LEU A CD1 1 
ATOM   333  C  CD2 . LEU A 1 55  ? 30.72900 -41.05900 55.23600 1.000 29.07470 ? 49  LEU A CD2 1 
ATOM   334  N  N   . LEU A 1 56  ? 34.32600 -38.74800 58.75800 1.000 26.24761 ? 50  LEU A N   1 
ATOM   335  C  CA  . LEU A 1 56  ? 34.65100 -37.69500 59.70700 1.000 29.37981 ? 50  LEU A CA  1 
ATOM   336  C  C   . LEU A 1 56  ? 35.42400 -36.55100 59.06800 1.000 34.86860 ? 50  LEU A C   1 
ATOM   337  O  O   . LEU A 1 56  ? 35.51300 -35.47400 59.66600 1.000 30.89644 ? 50  LEU A O   1 
ATOM   338  C  CB  . LEU A 1 56  ? 35.47400 -38.27000 60.86900 1.000 38.24761 ? 50  LEU A CB  1 
ATOM   339  C  CG  . LEU A 1 56  ? 34.93400 -39.46000 61.67300 1.000 41.54783 ? 50  LEU A CG  1 
ATOM   340  C  CD1 . LEU A 1 56  ? 36.05500 -40.07400 62.52400 1.000 37.77300 ? 50  LEU A CD1 1 
ATOM   341  C  CD2 . LEU A 1 56  ? 33.74800 -39.04000 62.55000 1.000 38.83993 ? 50  LEU A CD2 1 
ATOM   342  N  N   . LYS A 1 57  ? 35.98700 -36.76700 57.85900 1.000 32.70427 ? 51  LYS A N   1 
ATOM   343  C  CA  . LYS A 1 57  ? 36.90200 -35.85900 57.18900 1.000 28.95562 ? 51  LYS A CA  1 
ATOM   344  C  C   . LYS A 1 57  ? 36.16000 -34.77900 56.41200 1.000 29.52857 ? 51  LYS A C   1 
ATOM   345  O  O   . LYS A 1 57  ? 34.99500 -34.95200 56.01800 1.000 27.34476 ? 51  LYS A O   1 
ATOM   346  C  CB  . LYS A 1 57  ? 37.80000 -36.63800 56.23000 1.000 29.62896 ? 51  LYS A CB  1 
ATOM   347  C  CG  . LYS A 1 57  ? 38.65400 -37.69800 56.89900 1.000 30.93728 ? 51  LYS A CG  1 
ATOM   348  C  CD  . LYS A 1 57  ? 39.46200 -38.47700 55.87400 1.000 30.81161 ? 51  LYS A CD  1 
ATOM   349  C  CE  . LYS A 1 57  ? 40.31500 -39.54800 56.54900 1.000 33.70887 ? 51  LYS A CE  1 
ATOM   350  N  NZ  . LYS A 1 57  ? 41.05000 -40.34800 55.54200 1.000 36.06263 ? 51  LYS A NZ  1 
ATOM   351  N  N   . PRO A 1 58  ? 36.82700 -33.65600 56.14600 1.000 31.92136 ? 52  PRO A N   1 
ATOM   352  C  CA  . PRO A 1 58  ? 36.26700 -32.67800 55.21000 1.000 28.63004 ? 52  PRO A CA  1 
ATOM   353  C  C   . PRO A 1 58  ? 36.22100 -33.25600 53.81200 1.000 27.87084 ? 52  PRO A C   1 
ATOM   354  O  O   . PRO A 1 58  ? 37.04500 -34.09600 53.44400 1.000 26.70496 ? 52  PRO A O   1 
ATOM   355  C  CB  . PRO A 1 58  ? 37.24500 -31.50200 55.28900 1.000 28.58748 ? 52  PRO A CB  1 
ATOM   356  C  CG  . PRO A 1 58  ? 37.97400 -31.70400 56.59200 1.000 27.88853 ? 52  PRO A CG  1 
ATOM   357  C  CD  . PRO A 1 58  ? 38.07800 -33.18100 56.75100 1.000 26.86155 ? 52  PRO A CD  1 
ATOM   358  N  N   . GLN A 1 59  ? 35.24900 -32.78000 53.03200 1.000 23.99944 ? 53  GLN A N   1 
ATOM   359  C  CA  . GLN A 1 59  ? 35.03500 -33.21600 51.65400 1.000 20.45604 ? 53  GLN A CA  1 
ATOM   360  C  C   . GLN A 1 59  ? 35.26300 -32.03500 50.72200 1.000 25.01553 ? 53  GLN A C   1 
ATOM   361  O  O   . GLN A 1 59  ? 34.59600 -31.00300 50.85300 1.000 22.75185 ? 53  GLN A O   1 
ATOM   362  C  CB  . GLN A 1 59  ? 33.61700 -33.75500 51.48200 1.000 25.46576 ? 53  GLN A CB  1 
ATOM   363  C  CG  . GLN A 1 59  ? 33.35200 -35.03200 52.26400 1.000 24.55069 ? 53  GLN A CG  1 
ATOM   364  C  CD  . GLN A 1 59  ? 31.96600 -35.59100 52.01100 1.000 32.45712 ? 53  GLN A CD  1 
ATOM   365  O  OE1 . GLN A 1 59  ? 31.24900 -35.18000 51.06400 1.000 26.02434 ? 53  GLN A OE1 1 
ATOM   366  N  NE2 . GLN A 1 59  ? 31.59100 -36.56900 52.82300 1.000 24.30893 ? 53  GLN A NE2 1 
ATOM   367  N  N   . ILE A 1 60  ? 36.17800 -32.20000 49.77200 1.000 22.12920 ? 54  ILE A N   1 
ATOM   368  C  CA  . ILE A 1 60  ? 36.59700 -31.14000 48.86700 1.000 21.25739 ? 54  ILE A CA  1 
ATOM   369  C  C   . ILE A 1 60  ? 36.02600 -31.45700 47.49500 1.000 19.40029 ? 54  ILE A C   1 
ATOM   370  O  O   . ILE A 1 60  ? 36.31900 -32.51500 46.92700 1.000 21.02816 ? 54  ILE A O   1 
ATOM   371  C  CB  . ILE A 1 60  ? 38.12800 -31.03500 48.79100 1.000 23.74771 ? 54  ILE A CB  1 
ATOM   372  C  CG1 . ILE A 1 60  ? 38.74400 -30.86400 50.19300 1.000 22.43418 ? 54  ILE A CG1 1 
ATOM   373  C  CG2 . ILE A 1 60  ? 38.53600 -29.89700 47.81000 1.000 23.25597 ? 54  ILE A CG2 1 
ATOM   374  C  CD1 . ILE A 1 60  ? 38.06900 -29.78000 51.04100 1.000 17.65880 ? 54  ILE A CD1 1 
ATOM   375  N  N   . GLY A 1 61  ? 35.19100 -30.56500 46.97600 1.000 21.20241 ? 55  GLY A N   1 
ATOM   376  C  CA  . GLY A 1 61  ? 34.78300 -30.66300 45.58700 1.000 18.81613 ? 55  GLY A CA  1 
ATOM   377  C  C   . GLY A 1 61  ? 35.89400 -30.17300 44.68900 1.000 19.95449 ? 55  GLY A C   1 
ATOM   378  O  O   . GLY A 1 61  ? 36.33900 -29.02600 44.81000 1.000 20.32192 ? 55  GLY A O   1 
ATOM   379  N  N   . ILE A 1 62  ? 36.37700 -31.03600 43.80800 1.000 20.97336 ? 56  ILE A N   1 
ATOM   380  C  CA  . ILE A 1 62  ? 37.47200 -30.71700 42.90600 1.000 17.91744 ? 56  ILE A CA  1 
ATOM   381  C  C   . ILE A 1 62  ? 36.84200 -30.57100 41.52500 1.000 20.60309 ? 56  ILE A C   1 
ATOM   382  O  O   . ILE A 1 62  ? 36.51300 -31.57200 40.87400 1.000 20.37124 ? 56  ILE A O   1 
ATOM   383  C  CB  . ILE A 1 62  ? 38.58300 -31.78400 42.93000 1.000 20.98100 ? 56  ILE A CB  1 
ATOM   384  C  CG1 . ILE A 1 62  ? 39.20600 -31.93000 44.34100 1.000 19.10096 ? 56  ILE A CG1 1 
ATOM   385  C  CG2 . ILE A 1 62  ? 39.68700 -31.47800 41.91000 1.000 17.83795 ? 56  ILE A CG2 1 
ATOM   386  C  CD1 . ILE A 1 62  ? 39.74700 -33.34900 44.60700 1.000 20.75048 ? 56  ILE A CD1 1 
ATOM   387  N  N   . SER A 1 63  ? 36.65700 -29.31700 41.07500 1.000 17.81019 ? 57  SER A N   1 
ATOM   388  C  CA  . SER A 1 63  ? 35.94200 -29.01300 39.83200 1.000 18.68772 ? 57  SER A CA  1 
ATOM   389  C  C   . SER A 1 63  ? 36.91300 -28.59300 38.74000 1.000 19.47213 ? 57  SER A C   1 
ATOM   390  O  O   . SER A 1 63  ? 37.39600 -27.45200 38.73700 1.000 18.67573 ? 57  SER A O   1 
ATOM   391  C  CB  . SER A 1 63  ? 34.91100 -27.90600 40.05600 1.000 20.08247 ? 57  SER A CB  1 
ATOM   392  O  OG  . SER A 1 63  ? 35.39300 -26.93600 40.98000 1.000 21.89157 ? 57  SER A OG  1 
ATOM   393  N  N   . SER A 1 64  ? 37.13700 -29.48800 37.77900 1.000 20.92494 ? 58  SER A N   1 
ATOM   394  C  CA  . SER A 1 64  ? 37.93800 -29.22500 36.59500 1.000 19.54538 ? 58  SER A CA  1 
ATOM   395  C  C   . SER A 1 64  ? 37.04600 -28.86200 35.41700 1.000 19.66324 ? 58  SER A C   1 
ATOM   396  O  O   . SER A 1 64  ? 35.85000 -29.15200 35.40200 1.000 16.82166 ? 58  SER A O   1 
ATOM   397  C  CB  . SER A 1 64  ? 38.75900 -30.45700 36.21900 1.000 21.09020 ? 58  SER A CB  1 
ATOM   398  O  OG  . SER A 1 64  ? 37.93100 -31.60900 36.32800 1.000 20.44073 ? 58  SER A OG  1 
ATOM   399  N  N   . VAL A 1 65  ? 37.65900 -28.25800 34.40300 1.000 18.88969 ? 59  VAL A N   1 
ATOM   400  C  CA  . VAL A 1 65  ? 36.96300 -27.94700 33.15900 1.000 20.58234 ? 59  VAL A CA  1 
ATOM   401  C  C   . VAL A 1 65  ? 37.65700 -28.69400 32.02300 1.000 22.26123 ? 59  VAL A C   1 
ATOM   402  O  O   . VAL A 1 65  ? 37.99000 -28.11400 30.98700 1.000 20.50073 ? 59  VAL A O   1 
ATOM   403  C  CB  . VAL A 1 65  ? 36.91600 -26.43000 32.89700 1.000 18.51996 ? 59  VAL A CB  1 
ATOM   404  C  CG1 . VAL A 1 65  ? 35.92700 -26.09300 31.75400 1.000 19.05026 ? 59  VAL A CG1 1 
ATOM   405  C  CG2 . VAL A 1 65  ? 36.53000 -25.67900 34.16900 1.000 18.59534 ? 59  VAL A CG2 1 
ATOM   406  N  N   . TRP A 1 66  ? 37.87700 -29.98900 32.21200 1.000 20.44654 ? 60  TRP A N   1 
ATOM   407  C  CA  . TRP A 1 66  ? 38.49200 -30.79300 31.16500 1.000 23.58309 ? 60  TRP A CA  1 
ATOM   408  C  C   . TRP A 1 66  ? 37.52500 -31.00700 30.01000 1.000 22.33046 ? 60  TRP A C   1 
ATOM   409  O  O   . TRP A 1 66  ? 36.33400 -31.21500 30.22600 1.000 20.37457 ? 60  TRP A O   1 
ATOM   410  C  CB  . TRP A 1 66  ? 38.90500 -32.15100 31.71600 1.000 20.88309 ? 60  TRP A CB  1 
ATOM   411  C  CG  . TRP A 1 66  ? 39.10200 -33.21500 30.66400 1.000 21.78133 ? 60  TRP A CG  1 
ATOM   412  C  CD1 . TRP A 1 66  ? 40.19400 -33.37500 29.83900 1.000 21.45482 ? 60  TRP A CD1 1 
ATOM   413  C  CD2 . TRP A 1 66  ? 38.21600 -34.30700 30.37500 1.000 22.46477 ? 60  TRP A CD2 1 
ATOM   414  N  NE1 . TRP A 1 66  ? 40.02500 -34.50100 29.05000 1.000 25.47640 ? 60  TRP A NE1 1 
ATOM   415  C  CE2 . TRP A 1 66  ? 38.82400 -35.08500 29.35600 1.000 21.50576 ? 60  TRP A CE2 1 
ATOM   416  C  CE3 . TRP A 1 66  ? 36.96600 -34.70500 30.88000 1.000 22.67409 ? 60  TRP A CE3 1 
ATOM   417  C  CZ2 . TRP A 1 66  ? 38.22500 -36.23100 28.82900 1.000 21.98462 ? 60  TRP A CZ2 1 
ATOM   418  C  CZ3 . TRP A 1 66  ? 36.36700 -35.85300 30.35400 1.000 24.38639 ? 60  TRP A CZ3 1 
ATOM   419  C  CH2 . TRP A 1 66  ? 36.99600 -36.59500 29.33300 1.000 27.26981 ? 60  TRP A CH2 1 
ATOM   420  N  N   . TYR A 1 67  ? 38.04400 -30.92100 28.78500 1.000 23.64019 ? 61  TYR A N   1 
ATOM   421  C  CA  . TYR A 1 67  ? 37.41500 -31.54100 27.62000 1.000 19.86081 ? 61  TYR A CA  1 
ATOM   422  C  C   . TYR A 1 67  ? 38.47500 -31.69400 26.54100 1.000 23.84410 ? 61  TYR A C   1 
ATOM   423  O  O   . TYR A 1 67  ? 39.51300 -31.01900 26.55400 1.000 23.84920 ? 61  TYR A O   1 
ATOM   424  C  CB  . TYR A 1 67  ? 36.18400 -30.77200 27.11000 1.000 21.43565 ? 61  TYR A CB  1 
ATOM   425  C  CG  . TYR A 1 67  ? 36.40800 -29.33500 26.70100 1.000 23.15253 ? 61  TYR A CG  1 
ATOM   426  C  CD1 . TYR A 1 67  ? 36.47200 -28.33500 27.66200 1.000 19.20606 ? 61  TYR A CD1 1 
ATOM   427  C  CD2 . TYR A 1 67  ? 36.46400 -28.96500 25.35000 1.000 22.85063 ? 61  TYR A CD2 1 
ATOM   428  C  CE1 . TYR A 1 67  ? 36.66200 -27.01600 27.31700 1.000 23.42289 ? 61  TYR A CE1 1 
ATOM   429  C  CE2 . TYR A 1 67  ? 36.63200 -27.64300 24.98200 1.000 22.89735 ? 61  TYR A CE2 1 
ATOM   430  C  CZ  . TYR A 1 67  ? 36.73300 -26.67100 25.96900 1.000 27.81657 ? 61  TYR A CZ  1 
ATOM   431  O  OH  . TYR A 1 67  ? 36.92100 -25.36000 25.62400 1.000 29.71964 ? 61  TYR A OH  1 
ATOM   432  N  N   . GLU A 1 68  ? 38.21700 -32.62200 25.62700 1.000 21.97125 ? 62  GLU A N   1 
ATOM   433  C  CA  . GLU A 1 68  ? 39.26500 -33.08100 24.72500 1.000 26.94594 ? 62  GLU A CA  1 
ATOM   434  C  C   . GLU A 1 68  ? 39.40600 -32.20700 23.48900 1.000 25.44731 ? 62  GLU A C   1 
ATOM   435  O  O   . GLU A 1 68  ? 40.45300 -32.25300 22.83400 1.000 28.71221 ? 62  GLU A O   1 
ATOM   436  C  CB  . GLU A 1 68  ? 39.01200 -34.53700 24.30900 1.000 24.31184 ? 62  GLU A CB  1 
ATOM   437  C  CG  . GLU A 1 68  ? 39.10000 -35.56200 25.44800 1.000 22.76557 ? 62  GLU A CG  1 
ATOM   438  C  CD  . GLU A 1 68  ? 38.88700 -36.99000 24.94600 1.000 21.90423 ? 62  GLU A CD  1 
ATOM   439  O  OE1 . GLU A 1 68  ? 38.11900 -37.17600 23.99400 1.000 23.85629 ? 62  GLU A OE1 1 
ATOM   440  O  OE2 . GLU A 1 68  ? 39.49600 -37.92500 25.49200 1.000 25.31887 ? 62  GLU A OE2 1 
ATOM   441  N  N   . GLY A 1 69  ? 38.41000 -31.38500 23.18400 1.000 22.09500 ? 63  GLY A N   1 
ATOM   442  C  CA  . GLY A 1 69  ? 38.41600 -30.64900 21.93500 1.000 23.03899 ? 63  GLY A CA  1 
ATOM   443  C  C   . GLY A 1 69  ? 39.08100 -29.29000 21.99100 1.000 27.92177 ? 63  GLY A C   1 
ATOM   444  O  O   . GLY A 1 69  ? 38.86700 -28.46100 21.10300 1.000 30.41884 ? 63  GLY A O   1 
ATOM   445  N  N   . ASN A 1 70  ? 39.89000 -29.03500 23.01400 1.000 25.66660 ? 64  ASN A N   1 
ATOM   446  C  CA  . ASN A 1 70  ? 40.58800 -27.76100 23.09100 1.000 25.08771 ? 64  ASN A CA  1 
ATOM   447  C  C   . ASN A 1 70  ? 41.93200 -27.96800 23.76600 1.000 28.34762 ? 64  ASN A C   1 
ATOM   448  O  O   . ASN A 1 70  ? 42.01100 -28.66700 24.77900 1.000 25.08927 ? 64  ASN A O   1 
ATOM   449  C  CB  . ASN A 1 70  ? 39.76700 -26.71300 23.85600 1.000 30.78227 ? 64  ASN A CB  1 
ATOM   450  C  CG  . ASN A 1 70  ? 40.33300 -25.30000 23.70000 1.000 33.78737 ? 64  ASN A CG  1 
ATOM   451  O  OD1 . ASN A 1 70  ? 41.03200 -25.00300 22.72600 1.000 35.13939 ? 64  ASN A OD1 1 
ATOM   452  N  ND2 . ASN A 1 70  ? 40.01900 -24.42200 24.64400 1.000 28.42383 ? 64  ASN A ND2 1 
ATOM   453  N  N   . THR A 1 71  ? 42.98200 -27.35800 23.20600 1.000 25.99690 ? 65  THR A N   1 
ATOM   454  C  CA  . THR A 1 71  ? 44.31700 -27.48700 23.79400 1.000 30.68328 ? 65  THR A CA  1 
ATOM   455  C  C   . THR A 1 71  ? 44.36900 -26.90500 25.20600 1.000 31.71636 ? 65  THR A C   1 
ATOM   456  O  O   . THR A 1 71  ? 45.06500 -27.44200 26.07500 1.000 29.18824 ? 65  THR A O   1 
ATOM   457  C  CB  . THR A 1 71  ? 45.35900 -26.79900 22.91200 1.000 31.26451 ? 65  THR A CB  1 
ATOM   458  O  OG1 . THR A 1 71  ? 44.84800 -25.52700 22.49400 1.000 28.69574 ? 65  THR A OG1 1 
ATOM   459  C  CG2 . THR A 1 71  ? 45.70200 -27.67000 21.68500 1.000 28.36477 ? 65  THR A CG2 1 
ATOM   460  N  N   . CYS A 1 72  ? 43.64400 -25.80400 25.45400 1.000 28.04732 ? 66  CYS A N   1 
ATOM   461  C  CA  . CYS A 1 72  ? 43.61200 -25.20600 26.79300 1.000 33.71301 ? 66  CYS A CA  1 
ATOM   462  C  C   . CYS A 1 72  ? 43.05500 -26.14800 27.86300 1.000 37.04297 ? 66  CYS A C   1 
ATOM   463  O  O   . CYS A 1 72  ? 43.30400 -25.92000 29.05400 1.000 33.45877 ? 66  CYS A O   1 
ATOM   464  C  CB  . CYS A 1 72  ? 42.76300 -23.92200 26.82400 1.000 31.72852 ? 66  CYS A CB  1 
ATOM   465  S  SG  . CYS A 1 72  ? 42.68400 -22.89800 25.30000 1.000 47.21371 ? 66  CYS A SG  1 
ATOM   466  N  N   . ASN A 1 73  ? 42.27300 -27.16900 27.48100 1.000 25.85691 ? 67  ASN A N   1 
ATOM   467  C  CA  . ASN A 1 73  ? 41.53300 -27.95500 28.45800 1.000 29.39337 ? 67  ASN A CA  1 
ATOM   468  C  C   . ASN A 1 73  ? 41.81700 -29.44700 28.43900 1.000 26.48297 ? 67  ASN A C   1 
ATOM   469  O  O   . ASN A 1 73  ? 41.35800 -30.14900 29.34900 1.000 23.56262 ? 67  ASN A O   1 
ATOM   470  C  CB  . ASN A 1 73  ? 40.02200 -27.73900 28.26600 1.000 25.64397 ? 67  ASN A CB  1 
ATOM   471  C  CG  . ASN A 1 73  ? 39.63900 -26.28000 28.43300 1.000 26.58893 ? 67  ASN A CG  1 
ATOM   472  O  OD1 . ASN A 1 73  ? 39.75900 -25.49300 27.49300 1.000 27.30685 ? 67  ASN A OD1 1 
ATOM   473  N  ND2 . ASN A 1 73  ? 39.18400 -25.91000 29.62600 1.000 24.13550 ? 67  ASN A ND2 1 
ATOM   474  N  N   . MET A 1 74  ? 42.56300 -29.95700 27.46100 1.000 25.67988 ? 68  MET A N   1 
ATOM   475  C  CA  . MET A 1 74  ? 42.65500 -31.40700 27.31900 1.000 27.53296 ? 68  MET A CA  1 
ATOM   476  C  C   . MET A 1 74  ? 43.50900 -32.06000 28.41200 1.000 27.05195 ? 68  MET A C   1 
ATOM   477  O  O   . MET A 1 74  ? 43.38800 -33.26800 28.63900 1.000 27.97097 ? 68  MET A O   1 
ATOM   478  C  CB  . MET A 1 74  ? 43.21500 -31.75500 25.94000 1.000 23.90635 ? 68  MET A CB  1 
ATOM   479  C  CG  . MET A 1 74  ? 44.55000 -31.14000 25.64700 1.000 29.69084 ? 68  MET A CG  1 
ATOM   480  S  SD  . MET A 1 74  ? 45.10200 -31.57500 23.96600 1.000 36.72486 ? 68  MET A SD  1 
ATOM   481  C  CE  . MET A 1 74  ? 46.61100 -30.62600 23.86000 1.000 32.16846 ? 68  MET A CE  1 
ATOM   482  N  N   . HIS A 1 75  ? 44.34000 -31.29500 29.10000 1.000 27.44837 ? 69  HIS A N   1 
ATOM   483  C  CA  . HIS A 1 75  ? 45.22300 -31.82500 30.13300 1.000 30.06536 ? 69  HIS A CA  1 
ATOM   484  C  C   . HIS A 1 75  ? 44.64600 -31.74500 31.53600 1.000 30.15431 ? 69  HIS A C   1 
ATOM   485  O  O   . HIS A 1 75  ? 45.31000 -32.18400 32.47900 1.000 28.01877 ? 69  HIS A O   1 
ATOM   486  C  CB  . HIS A 1 75  ? 46.55100 -31.06900 30.10800 1.000 32.15824 ? 69  HIS A CB  1 
ATOM   487  C  CG  . HIS A 1 75  ? 46.41800 -29.60700 30.42500 1.000 36.78076 ? 69  HIS A CG  1 
ATOM   488  N  ND1 . HIS A 1 75  ? 45.48300 -28.79100 29.81500 1.000 38.32039 ? 69  HIS A ND1 1 
ATOM   489  C  CD2 . HIS A 1 75  ? 47.12300 -28.80700 31.26400 1.000 37.98006 ? 69  HIS A CD2 1 
ATOM   490  C  CE1 . HIS A 1 75  ? 45.61000 -27.55800 30.27600 1.000 35.76767 ? 69  HIS A CE1 1 
ATOM   491  N  NE2 . HIS A 1 75  ? 46.60100 -27.54000 31.15200 1.000 37.28598 ? 69  HIS A NE2 1 
ATOM   492  N  N   . LEU A 1 76  ? 43.43300 -31.20600 31.71200 1.000 27.07755 ? 70  LEU A N   1 
ATOM   493  C  CA  . LEU A 1 76  ? 42.99400 -30.84200 33.05600 1.000 27.19735 ? 70  LEU A CA  1 
ATOM   494  C  C   . LEU A 1 76  ? 42.54200 -32.03900 33.88500 1.000 27.23536 ? 70  LEU A C   1 
ATOM   495  O  O   . LEU A 1 76  ? 42.48200 -31.93100 35.11100 1.000 25.43277 ? 70  LEU A O   1 
ATOM   496  C  CB  . LEU A 1 76  ? 41.87500 -29.79400 32.98400 1.000 25.52356 ? 70  LEU A CB  1 
ATOM   497  C  CG  . LEU A 1 76  ? 42.25700 -28.48100 32.30200 1.000 30.01067 ? 70  LEU A CG  1 
ATOM   498  C  CD1 . LEU A 1 76  ? 41.07800 -27.49100 32.28800 1.000 28.06946 ? 70  LEU A CD1 1 
ATOM   499  C  CD2 . LEU A 1 76  ? 43.48000 -27.86800 32.98200 1.000 27.04353 ? 70  LEU A CD2 1 
ATOM   500  N  N   . LEU A 1 77  ? 42.22700 -33.17100 33.25800 1.000 26.53547 ? 71  LEU A N   1 
ATOM   501  C  CA  . LEU A 1 77  ? 41.92700 -34.36600 34.03600 1.000 26.92890 ? 71  LEU A CA  1 
ATOM   502  C  C   . LEU A 1 77  ? 43.18000 -34.88300 34.72200 1.000 28.76438 ? 71  LEU A C   1 
ATOM   503  O  O   . LEU A 1 77  ? 43.14000 -35.27400 35.89600 1.000 25.59205 ? 71  LEU A O   1 
ATOM   504  C  CB  . LEU A 1 77  ? 41.31600 -35.42900 33.12700 1.000 32.74648 ? 71  LEU A CB  1 
ATOM   505  C  CG  . LEU A 1 77  ? 40.20900 -36.30600 33.68600 1.000 38.11103 ? 71  LEU A CG  1 
ATOM   506  C  CD1 . LEU A 1 77  ? 39.17700 -35.50000 34.43500 1.000 32.98680 ? 71  LEU A CD1 1 
ATOM   507  C  CD2 . LEU A 1 77  ? 39.57200 -37.04700 32.53800 1.000 32.38364 ? 71  LEU A CD2 1 
ATOM   508  N  N   . LYS A 1 78  ? 44.31800 -34.86600 34.01700 1.000 28.79135 ? 72  LYS A N   1 
ATOM   509  C  CA  . LYS A 1 78  ? 45.57100 -35.25300 34.66400 1.000 28.56545 ? 72  LYS A CA  1 
ATOM   510  C  C   . LYS A 1 78  ? 45.89000 -34.33900 35.84400 1.000 27.83245 ? 72  LYS A C   1 
ATOM   511  O  O   . LYS A 1 78  ? 46.28800 -34.81400 36.91400 1.000 26.16787 ? 72  LYS A O   1 
ATOM   512  C  CB  . LYS A 1 78  ? 46.71300 -35.26500 33.64500 1.000 32.38271 ? 72  LYS A CB  1 
ATOM   513  C  CG  . LYS A 1 78  ? 48.10900 -35.37100 34.27300 1.000 38.96378 ? 72  LYS A CG  1 
ATOM   514  C  CD  . LYS A 1 78  ? 49.21600 -35.11800 33.23700 1.000 47.15168 ? 72  LYS A CD  1 
ATOM   515  C  CE  . LYS A 1 78  ? 49.04500 -33.75400 32.53700 1.000 49.14187 ? 72  LYS A CE  1 
ATOM   516  N  NZ  . LYS A 1 78  ? 49.89200 -33.60500 31.30700 1.000 53.36239 ? 72  LYS A NZ  1 
ATOM   517  N  N   . LEU A 1 79  ? 45.65300 -33.03900 35.71100 1.000 26.40158 ? 73  LEU A N   1 
ATOM   518  C  CA  . LEU A 1 79  ? 45.86300 -32.12600 36.86700 1.000 21.06447 ? 73  LEU A CA  1 
ATOM   519  C  C   . LEU A 1 79  ? 44.88400 -32.46300 37.99900 1.000 24.93253 ? 73  LEU A C   1 
ATOM   520  O  O   . LEU A 1 79  ? 45.29900 -32.41300 39.14600 1.000 22.55758 ? 73  LEU A O   1 
ATOM   521  C  CB  . LEU A 1 79  ? 45.68400 -30.67100 36.43500 1.000 21.94287 ? 73  LEU A CB  1 
ATOM   522  C  CG  . LEU A 1 79  ? 46.56800 -30.15400 35.30200 1.000 29.57423 ? 73  LEU A CG  1 
ATOM   523  C  CD1 . LEU A 1 79  ? 46.53100 -28.63800 35.26400 1.000 25.92406 ? 73  LEU A CD1 1 
ATOM   524  C  CD2 . LEU A 1 79  ? 48.00200 -30.63600 35.43200 1.000 30.19103 ? 73  LEU A CD2 1 
ATOM   525  N  N   . SER A 1 80  ? 43.63700 -32.79600 37.66800 1.000 22.18522 ? 74  SER A N   1 
ATOM   526  C  CA  . SER A 1 80  ? 42.59600 -33.08000 38.68700 1.000 23.24753 ? 74  SER A CA  1 
ATOM   527  C  C   . SER A 1 80  ? 43.00200 -34.29200 39.53200 1.000 23.92687 ? 74  SER A C   1 
ATOM   528  O  O   . SER A 1 80  ? 42.74500 -34.28000 40.71900 1.000 21.54710 ? 74  SER A O   1 
ATOM   529  C  CB  . SER A 1 80  ? 41.24200 -33.25000 38.04300 1.000 25.36151 ? 74  SER A CB  1 
ATOM   530  O  OG  . SER A 1 80  ? 41.09200 -34.51200 37.42900 1.000 27.42857 ? 74  SER A OG  1 
ATOM   531  N  N   . GLU A 1 81  ? 43.62200 -35.28000 38.89700 1.000 26.73991 ? 75  GLU A N   1 
ATOM   532  C  CA  . GLU A 1 81  ? 44.09600 -36.48400 39.62300 1.000 29.82455 ? 75  GLU A CA  1 
ATOM   533  C  C   . GLU A 1 81  ? 45.15400 -36.05100 40.63800 1.000 25.74615 ? 75  GLU A C   1 
ATOM   534  O  O   . GLU A 1 81  ? 45.10100 -36.52200 41.76600 1.000 28.39348 ? 75  GLU A O   1 
ATOM   535  C  CB  . GLU A 1 81  ? 44.61000 -37.54300 38.64600 1.000 30.52964 ? 75  GLU A CB  1 
ATOM   536  C  CG  . GLU A 1 81  ? 44.97100 -38.86500 39.29800 1.000 33.59171 ? 75  GLU A CG  1 
ATOM   537  C  CD  . GLU A 1 81  ? 43.97500 -39.43300 40.29600 1.000 42.97795 ? 75  GLU A CD  1 
ATOM   538  O  OE1 . GLU A 1 81  ? 42.77400 -39.47800 39.98200 1.000 45.38984 ? 75  GLU A OE1 1 
ATOM   539  O  OE2 . GLU A 1 81  ? 44.40900 -39.84600 41.38200 1.000 47.66735 ? 75  GLU A OE2 1 
ATOM   540  N  N   . ALA A 1 82  ? 46.05100 -35.15700 40.23200 1.000 29.20176 ? 76  ALA A N   1 
ATOM   541  C  CA  . ALA A 1 82  ? 47.06100 -34.68000 41.17100 1.000 27.62570 ? 76  ALA A CA  1 
ATOM   542  C  C   . ALA A 1 82  ? 46.43500 -33.88200 42.31200 1.000 28.71005 ? 76  ALA A C   1 
ATOM   543  O  O   . ALA A 1 82  ? 46.86100 -34.00400 43.46700 1.000 30.32484 ? 76  ALA A O   1 
ATOM   544  C  CB  . ALA A 1 82  ? 48.10000 -33.83900 40.42600 1.000 28.18774 ? 76  ALA A CB  1 
ATOM   545  N  N   . VAL A 1 83  ? 45.43200 -33.03600 42.01700 1.000 25.43617 ? 77  VAL A N   1 
ATOM   546  C  CA  . VAL A 1 83  ? 44.76100 -32.31100 43.09400 1.000 21.72872 ? 77  VAL A CA  1 
ATOM   547  C  C   . VAL A 1 83  ? 44.12400 -33.28300 44.07600 1.000 22.09984 ? 77  VAL A C   1 
ATOM   548  O  O   . VAL A 1 83  ? 44.25400 -33.13400 45.30100 1.000 24.06899 ? 77  VAL A O   1 
ATOM   549  C  CB  . VAL A 1 83  ? 43.71400 -31.32900 42.54000 1.000 25.01293 ? 77  VAL A CB  1 
ATOM   550  C  CG1 . VAL A 1 83  ? 42.86800 -30.82500 43.69300 1.000 21.26743 ? 77  VAL A CG1 1 
ATOM   551  C  CG2 . VAL A 1 83  ? 44.38000 -30.17700 41.85400 1.000 20.86260 ? 77  VAL A CG2 1 
ATOM   552  N  N   . LYS A 1 84  ? 43.42000 -34.29800 43.55900 1.000 19.16394 ? 78  LYS A N   1 
ATOM   553  C  CA  . LYS A 1 84  ? 42.81000 -35.28500 44.44900 1.000 20.96653 ? 78  LYS A CA  1 
ATOM   554  C  C   . LYS A 1 84  ? 43.85400 -35.99100 45.32100 1.000 24.01138 ? 78  LYS A C   1 
ATOM   555  O  O   . LYS A 1 84  ? 43.64100 -36.19400 46.52000 1.000 24.00598 ? 78  LYS A O   1 
ATOM   556  C  CB  . LYS A 1 84  ? 42.02100 -36.31300 43.63800 1.000 24.01808 ? 78  LYS A CB  1 
ATOM   557  C  CG  . LYS A 1 84  ? 41.34800 -37.36600 44.53200 1.000 22.38139 ? 78  LYS A CG  1 
ATOM   558  C  CD  . LYS A 1 84  ? 40.59200 -38.42900 43.68800 1.000 26.80664 ? 78  LYS A CD  1 
ATOM   559  C  CE  . LYS A 1 84  ? 39.69000 -39.33000 44.55300 1.000 23.01493 ? 78  LYS A CE  1 
ATOM   560  N  NZ  . LYS A 1 84  ? 39.12100 -40.33700 43.63500 1.000 33.94430 ? 78  LYS A NZ  1 
ATOM   561  N  N   . GLU A 1 85  ? 44.97900 -36.39800 44.73200 1.000 27.77292 ? 79  GLU A N   1 
ATOM   562  C  CA  . GLU A 1 85  ? 46.00400 -37.07700 45.52100 1.000 28.00251 ? 79  GLU A CA  1 
ATOM   563  C  C   . GLU A 1 85  ? 46.52300 -36.17000 46.64100 1.000 23.69142 ? 79  GLU A C   1 
ATOM   564  O  O   . GLU A 1 85  ? 46.67400 -36.61100 47.78500 1.000 32.31960 ? 79  GLU A O   1 
ATOM   565  C  CB  . GLU A 1 85  ? 47.13500 -37.54400 44.60100 1.000 29.92984 ? 79  GLU A CB  1 
ATOM   566  C  CG  . GLU A 1 85  ? 46.79500 -38.79700 43.76900 1.000 28.07378 ? 79  GLU A CG  1 
ATOM   567  C  CD  . GLU A 1 85  ? 47.75300 -39.01100 42.59100 1.000 34.05696 ? 79  GLU A CD  1 
ATOM   568  O  OE1 . GLU A 1 85  ? 48.85700 -38.41100 42.57000 1.000 37.82147 ? 79  GLU A OE1 1 
ATOM   569  O  OE2 . GLU A 1 85  ? 47.38800 -39.76300 41.66800 1.000 37.68048 ? 79  GLU A OE2 1 
ATOM   570  N  N   . GLY A 1 86  ? 46.74100 -34.88500 46.34600 1.000 25.51033 ? 80  GLY A N   1 
ATOM   571  C  CA  . GLY A 1 86  ? 47.14000 -33.95100 47.39200 1.000 25.67084 ? 80  GLY A CA  1 
ATOM   572  C  C   . GLY A 1 86  ? 46.07900 -33.74500 48.45500 1.000 28.78446 ? 80  GLY A C   1 
ATOM   573  O  O   . GLY A 1 86  ? 46.39400 -33.56700 49.63800 1.000 26.67331 ? 80  GLY A O   1 
ATOM   574  N  N   . VAL A 1 87  ? 44.80700 -33.74300 48.05200 1.000 26.44519 ? 81  VAL A N   1 
ATOM   575  C  CA  . VAL A 1 87  ? 43.72200 -33.60300 49.02400 1.000 23.86304 ? 81  VAL A CA  1 
ATOM   576  C  C   . VAL A 1 87  ? 43.74000 -34.77600 49.98900 1.000 25.39772 ? 81  VAL A C   1 
ATOM   577  O  O   . VAL A 1 87  ? 43.55800 -34.61400 51.20500 1.000 23.56860 ? 81  VAL A O   1 
ATOM   578  C  CB  . VAL A 1 87  ? 42.36400 -33.49500 48.29600 1.000 23.98353 ? 81  VAL A CB  1 
ATOM   579  C  CG1 . VAL A 1 87  ? 41.21900 -33.77200 49.24000 1.000 20.99731 ? 81  VAL A CG1 1 
ATOM   580  C  CG2 . VAL A 1 87  ? 42.22000 -32.11900 47.66000 1.000 21.59301 ? 81  VAL A CG2 1 
ATOM   581  N  N   . GLU A 1 88  ? 43.94200 -35.98200 49.45500 1.000 26.40797 ? 82  GLU A N   1 
ATOM   582  C  CA  . GLU A 1 88  ? 44.00100 -37.16800 50.30600 1.000 32.06602 ? 82  GLU A CA  1 
ATOM   583  C  C   . GLU A 1 88  ? 45.23300 -37.13000 51.20200 1.000 31.65824 ? 82  GLU A C   1 
ATOM   584  O  O   . GLU A 1 88  ? 45.14600 -37.44200 52.39600 1.000 34.67233 ? 82  GLU A O   1 
ATOM   585  C  CB  . GLU A 1 88  ? 43.97800 -38.44000 49.44500 1.000 28.65134 ? 82  GLU A CB  1 
ATOM   586  C  CG  . GLU A 1 88  ? 42.63100 -38.65800 48.77600 1.000 32.78887 ? 82  GLU A CG  1 
ATOM   587  C  CD  . GLU A 1 88  ? 42.65000 -39.70200 47.66400 1.000 39.38524 ? 82  GLU A CD  1 
ATOM   588  O  OE1 . GLU A 1 88  ? 43.74100 -40.04200 47.14200 1.000 40.51955 ? 82  GLU A OE1 1 
ATOM   589  O  OE2 . GLU A 1 88  ? 41.54900 -40.15600 47.29100 1.000 35.98127 ? 82  GLU A OE2 1 
ATOM   590  N  N   . ASN A 1 89  ? 46.38100 -36.72900 50.65200 1.000 31.07731 ? 83  ASN A N   1 
ATOM   591  C  CA  . ASN A 1 89  ? 47.59800 -36.61500 51.45900 1.000 32.77989 ? 83  ASN A CA  1 
ATOM   592  C  C   . ASN A 1 89  ? 47.49100 -35.56300 52.55400 1.000 38.98489 ? 83  ASN A C   1 
ATOM   593  O  O   . ASN A 1 89  ? 48.36100 -35.51900 53.43100 1.000 43.40226 ? 83  ASN A O   1 
ATOM   594  C  CB  . ASN A 1 89  ? 48.80500 -36.27100 50.58900 1.000 34.86670 ? 83  ASN A CB  1 
ATOM   595  C  CG  . ASN A 1 89  ? 49.13800 -37.35200 49.58600 1.000 38.73676 ? 83  ASN A CG  1 
ATOM   596  O  OD1 . ASN A 1 89  ? 48.74000 -38.51100 49.74200 1.000 46.22353 ? 83  ASN A OD1 1 
ATOM   597  N  ND2 . ASN A 1 89  ? 49.88800 -36.98200 48.54300 1.000 38.75613 ? 83  ASN A ND2 1 
ATOM   598  N  N   . ALA A 1 90  ? 46.48000 -34.69800 52.51300 1.000 35.01534 ? 84  ALA A N   1 
ATOM   599  C  CA  . ALA A 1 90  ? 46.25800 -33.70800 53.55700 1.000 31.46406 ? 84  ALA A CA  1 
ATOM   600  C  C   . ALA A 1 90  ? 45.17300 -34.13800 54.52300 1.000 29.39985 ? 84  ALA A C   1 
ATOM   601  O  O   . ALA A 1 90  ? 44.69900 -33.31400 55.31000 1.000 33.62095 ? 84  ALA A O   1 
ATOM   602  C  CB  . ALA A 1 90  ? 45.90800 -32.34100 52.95000 1.000 29.84637 ? 84  ALA A CB  1 
ATOM   603  N  N   . GLY A 1 91  ? 44.76400 -35.40600 54.47600 1.000 27.68467 ? 85  GLY A N   1 
ATOM   604  C  CA  . GLY A 1 91  ? 43.80000 -35.91700 55.42800 1.000 27.09169 ? 85  GLY A CA  1 
ATOM   605  C  C   . GLY A 1 91  ? 42.34900 -35.64300 55.10200 1.000 33.38556 ? 85  GLY A C   1 
ATOM   606  O  O   . GLY A 1 91  ? 41.50300 -35.74600 55.99100 1.000 28.36214 ? 85  GLY A O   1 
ATOM   607  N  N   . MET A 1 92  ? 42.02100 -35.31100 53.85500 1.000 30.86386 ? 86  MET A N   1 
ATOM   608  C  CA  . MET A 1 92  ? 40.65000 -34.99900 53.48500 1.000 26.44159 ? 86  MET A CA  1 
ATOM   609  C  C   . MET A 1 92  ? 40.17700 -35.93200 52.37400 1.000 24.57704 ? 86  MET A C   1 
ATOM   610  O  O   . MET A 1 92  ? 40.94600 -36.70700 51.80500 1.000 26.11192 ? 86  MET A O   1 
ATOM   611  C  CB  . MET A 1 92  ? 40.53000 -33.53600 53.03600 1.000 26.22904 ? 86  MET A CB  1 
ATOM   612  C  CG  . MET A 1 92  ? 41.21900 -32.55400 53.98200 1.000 31.35847 ? 86  MET A CG  1 
ATOM   613  S  SD  . MET A 1 92  ? 40.90000 -30.81600 53.57800 1.000 24.80058 ? 86  MET A SD  1 
ATOM   614  C  CE  . MET A 1 92  ? 42.07500 -30.58800 52.28000 1.000 22.97678 ? 86  MET A CE  1 
ATOM   615  N  N   . VAL A 1 93  ? 38.88500 -35.83100 52.06400 1.000 23.33830 ? 87  VAL A N   1 
ATOM   616  C  CA  . VAL A 1 93  ? 38.25100 -36.61300 51.01000 1.000 23.70010 ? 87  VAL A CA  1 
ATOM   617  C  C   . VAL A 1 93  ? 38.12400 -35.72900 49.76800 1.000 26.66172 ? 87  VAL A C   1 
ATOM   618  O  O   . VAL A 1 93  ? 37.61800 -34.60400 49.85100 1.000 27.69076 ? 87  VAL A O   1 
ATOM   619  C  CB  . VAL A 1 93  ? 36.87800 -37.14400 51.46700 1.000 28.40878 ? 87  VAL A CB  1 
ATOM   620  C  CG1 . VAL A 1 93  ? 36.16000 -37.89200 50.32400 1.000 29.91260 ? 87  VAL A CG1 1 
ATOM   621  C  CG2 . VAL A 1 93  ? 37.03100 -38.06000 52.67000 1.000 30.49058 ? 87  VAL A CG2 1 
ATOM   622  N  N   . GLY A 1 94  ? 38.59500 -36.22900 48.62700 1.000 22.89697 ? 88  GLY A N   1 
ATOM   623  C  CA  . GLY A 1 94  ? 38.51300 -35.50800 47.36500 1.000 25.63117 ? 88  GLY A CA  1 
ATOM   624  C  C   . GLY A 1 94  ? 37.47300 -36.11900 46.43800 1.000 30.48090 ? 88  GLY A C   1 
ATOM   625  O  O   . GLY A 1 94  ? 37.51500 -37.31100 46.14400 1.000 25.23195 ? 88  GLY A O   1 
ATOM   626  N  N   . PHE A 1 95  ? 36.53900 -35.28300 45.97500 1.000 24.98027 ? 89  PHE A N   1 
ATOM   627  C  CA  . PHE A 1 95  ? 35.48900 -35.71100 45.05800 1.000 18.54622 ? 89  PHE A CA  1 
ATOM   628  C  C   . PHE A 1 95  ? 35.60500 -34.89800 43.77300 1.000 20.81636 ? 89  PHE A C   1 
ATOM   629  O  O   . PHE A 1 95  ? 35.27100 -33.70600 43.74600 1.000 19.84824 ? 89  PHE A O   1 
ATOM   630  C  CB  . PHE A 1 95  ? 34.10600 -35.52800 45.67200 1.000 21.83081 ? 89  PHE A CB  1 
ATOM   631  C  CG  . PHE A 1 95  ? 33.71000 -36.60300 46.65300 1.000 25.10540 ? 89  PHE A CG  1 
ATOM   632  C  CD1 . PHE A 1 95  ? 33.77400 -37.94200 46.30700 1.000 28.42335 ? 89  PHE A CD1 1 
ATOM   633  C  CD2 . PHE A 1 95  ? 33.24600 -36.26900 47.90100 1.000 29.18780 ? 89  PHE A CD2 1 
ATOM   634  C  CE1 . PHE A 1 95  ? 33.38000 -38.92300 47.20100 1.000 33.01322 ? 89  PHE A CE1 1 
ATOM   635  C  CE2 . PHE A 1 95  ? 32.85500 -37.24700 48.80600 1.000 30.68470 ? 89  PHE A CE2 1 
ATOM   636  C  CZ  . PHE A 1 95  ? 32.91500 -38.57400 48.44000 1.000 29.15114 ? 89  PHE A CZ  1 
ATOM   637  N  N   . ARG A 1 96  ? 36.04900 -35.53900 42.70300 1.000 19.96707 ? 90  ARG A N   1 
ATOM   638  C  CA  . ARG A 1 96  ? 36.23600 -34.83800 41.44400 1.000 21.63803 ? 90  ARG A CA  1 
ATOM   639  C  C   . ARG A 1 96  ? 34.90100 -34.72000 40.72100 1.000 19.96406 ? 90  ARG A C   1 
ATOM   640  O  O   . ARG A 1 96  ? 34.07400 -35.63300 40.77600 1.000 20.59940 ? 90  ARG A O   1 
ATOM   641  C  CB  . ARG A 1 96  ? 37.25200 -35.56900 40.57200 1.000 22.17377 ? 90  ARG A CB  1 
ATOM   642  C  CG  . ARG A 1 96  ? 38.72000 -35.40800 41.06600 1.000 18.52742 ? 90  ARG A CG  1 
ATOM   643  C  CD  . ARG A 1 96  ? 39.71200 -35.91300 39.99600 1.000 24.60731 ? 90  ARG A CD  1 
ATOM   644  N  NE  . ARG A 1 96  ? 39.55300 -37.34200 39.74300 1.000 25.24854 ? 90  ARG A NE  1 
ATOM   645  C  CZ  . ARG A 1 96  ? 40.04700 -38.00000 38.70200 1.000 24.27198 ? 90  ARG A CZ  1 
ATOM   646  N  NH1 . ARG A 1 96  ? 40.76400 -37.39400 37.77400 1.000 26.53035 ? 90  ARG A NH1 1 
ATOM   647  N  NH2 . ARG A 1 96  ? 39.82900 -39.31000 38.60100 1.000 27.35757 ? 90  ARG A NH2 1 
ATOM   648  N  N   . PHE A 1 97  ? 34.68100 -33.56400 40.09300 1.000 20.27640 ? 91  PHE A N   1 
ATOM   649  C  CA  . PHE A 1 97  ? 33.61200 -33.39000 39.11800 1.000 18.11220 ? 91  PHE A CA  1 
ATOM   650  C  C   . PHE A 1 97  ? 34.10400 -32.40400 38.06800 1.000 21.06214 ? 91  PHE A C   1 
ATOM   651  O  O   . PHE A 1 97  ? 35.15100 -31.77500 38.21800 1.000 19.52754 ? 91  PHE A O   1 
ATOM   652  C  CB  . PHE A 1 97  ? 32.27900 -32.96500 39.76800 1.000 20.03034 ? 91  PHE A CB  1 
ATOM   653  C  CG  . PHE A 1 97  ? 32.28100 -31.59700 40.44600 1.000 17.93306 ? 91  PHE A CG  1 
ATOM   654  C  CD1 . PHE A 1 97  ? 32.79100 -31.44300 41.74100 1.000 19.30521 ? 91  PHE A CD1 1 
ATOM   655  C  CD2 . PHE A 1 97  ? 31.66300 -30.50200 39.83800 1.000 19.82778 ? 91  PHE A CD2 1 
ATOM   656  C  CE1 . PHE A 1 97  ? 32.73900 -30.20700 42.40300 1.000 16.29068 ? 91  PHE A CE1 1 
ATOM   657  C  CE2 . PHE A 1 97  ? 31.61000 -29.22900 40.47200 1.000 17.79083 ? 91  PHE A CE2 1 
ATOM   658  C  CZ  . PHE A 1 97  ? 32.16700 -29.08600 41.77400 1.000 16.46613 ? 91  PHE A CZ  1 
ATOM   659  N  N   . ASN A 1 98  ? 33.34700 -32.29000 36.98500 1.000 18.42119 ? 92  ASN A N   1 
ATOM   660  C  CA  . ASN A 1 98  ? 33.85300 -31.60100 35.81100 1.000 19.92515 ? 92  ASN A CA  1 
ATOM   661  C  C   . ASN A 1 98  ? 32.70700 -30.85800 35.13900 1.000 21.27523 ? 92  ASN A C   1 
ATOM   662  O  O   . ASN A 1 98  ? 31.61900 -31.41500 34.98700 1.000 23.55161 ? 92  ASN A O   1 
ATOM   663  C  CB  . ASN A 1 98  ? 34.49600 -32.63300 34.86800 1.000 20.48836 ? 92  ASN A CB  1 
ATOM   664  C  CG  . ASN A 1 98  ? 35.34300 -32.00400 33.78900 1.000 21.10898 ? 92  ASN A CG  1 
ATOM   665  O  OD1 . ASN A 1 98  ? 36.55100 -31.80200 33.95700 1.000 24.96068 ? 92  ASN A OD1 1 
ATOM   666  N  ND2 . ASN A 1 98  ? 34.71700 -31.71800 32.64600 1.000 17.83720 ? 92  ASN A ND2 1 
ATOM   667  N  N   . THR A 1 99  ? 32.93600 -29.60900 34.74300 1.000 17.54041 ? 93  THR A N   1 
ATOM   668  C  CA  A THR A 1 99  ? 31.91300 -28.87600 34.01600 0.463 18.25314 ? 93  THR A CA  1 
ATOM   669  C  CA  B THR A 1 99  ? 31.96000 -28.79300 34.03100 0.537 18.33720 ? 93  THR A CA  1 
ATOM   670  C  C   . THR A 1 99  ? 32.33400 -28.69700 32.55600 1.000 18.61793 ? 93  THR A C   1 
ATOM   671  O  O   . THR A 1 99  ? 33.35900 -29.21500 32.10800 1.000 18.17538 ? 93  THR A O   1 
ATOM   672  C  CB  A THR A 1 99  ? 31.61900 -27.53500 34.69200 0.463 19.75108 ? 93  THR A CB  1 
ATOM   673  C  CB  B THR A 1 99  ? 31.86500 -27.37800 34.61800 0.537 20.04657 ? 93  THR A CB  1 
ATOM   674  O  OG1 A THR A 1 99  ? 30.41200 -26.99300 34.13900 0.463 21.41354 ? 93  THR A OG1 1 
ATOM   675  O  OG1 B THR A 1 99  ? 32.96400 -26.59000 34.12400 0.537 19.84209 ? 93  THR A OG1 1 
ATOM   676  C  CG2 A THR A 1 99  ? 32.78200 -26.56500 34.48400 0.463 20.41202 ? 93  THR A CG2 1 
ATOM   677  C  CG2 B THR A 1 99  ? 31.89200 -27.39800 36.11300 0.537 18.67804 ? 93  THR A CG2 1 
ATOM   678  N  N   . ILE A 1 100 ? 31.50600 -27.97100 31.80400 1.000 18.60692 ? 94  ILE A N   1 
ATOM   679  C  CA  . ILE A 1 100 ? 31.77800 -27.74500 30.39300 1.000 17.29618 ? 94  ILE A CA  1 
ATOM   680  C  C   . ILE A 1 100 ? 32.61200 -26.48300 30.24100 1.000 17.01107 ? 94  ILE A C   1 
ATOM   681  O  O   . ILE A 1 100 ? 32.73200 -25.68800 31.17700 1.000 19.85554 ? 94  ILE A O   1 
ATOM   682  C  CB  . ILE A 1 100 ? 30.47300 -27.64000 29.57300 1.000 19.19342 ? 94  ILE A CB  1 
ATOM   683  C  CG1 . ILE A 1 100 ? 29.59300 -26.50700 30.11400 1.000 18.11156 ? 94  ILE A CG1 1 
ATOM   684  C  CG2 . ILE A 1 100 ? 29.69100 -28.96600 29.64700 1.000 18.44837 ? 94  ILE A CG2 1 
ATOM   685  C  CD1 . ILE A 1 100 ? 29.66000 -25.23400 29.35200 1.000 21.29992 ? 94  ILE A CD1 1 
ATOM   686  N  N   . GLY A 1 101 ? 33.15400 -26.27500 29.03900 1.000 18.84273 ? 95  GLY A N   1 
ATOM   687  C  CA  . GLY A 1 101 ? 33.79800 -25.03800 28.64200 1.000 18.65322 ? 95  GLY A CA  1 
ATOM   688  C  C   . GLY A 1 101 ? 33.78700 -25.00800 27.12600 1.000 23.82202 ? 95  GLY A C   1 
ATOM   689  O  O   . GLY A 1 101 ? 33.54600 -26.02600 26.47800 1.000 22.90027 ? 95  GLY A O   1 
ATOM   690  N  N   . VAL A 1 102 ? 34.06000 -23.83600 26.55500 1.000 22.71272 ? 96  VAL A N   1 
ATOM   691  C  CA  . VAL A 1 102 ? 34.12500 -23.71300 25.10100 1.000 28.84008 ? 96  VAL A CA  1 
ATOM   692  C  C   . VAL A 1 102 ? 35.40400 -22.97500 24.70400 1.000 23.43550 ? 96  VAL A C   1 
ATOM   693  O  O   . VAL A 1 102 ? 36.00000 -22.23600 25.49100 1.000 23.41059 ? 96  VAL A O   1 
ATOM   694  C  CB  . VAL A 1 102 ? 32.88300 -23.01400 24.49400 1.000 25.37189 ? 96  VAL A CB  1 
ATOM   695  C  CG1 . VAL A 1 102 ? 31.59100 -23.75900 24.86500 1.000 27.70585 ? 96  VAL A CG1 1 
ATOM   696  C  CG2 . VAL A 1 102 ? 32.80200 -21.55700 24.86500 1.000 24.73723 ? 96  VAL A CG2 1 
ATOM   697  N  N   . SER A 1 103 ? 35.82600 -23.20100 23.46000 1.000 23.83044 ? 97  SER A N   1 
ATOM   698  C  CA  . SER A 1 103 ? 37.09500 -22.68900 22.93300 1.000 25.83156 ? 97  SER A CA  1 
ATOM   699  C  C   . SER A 1 103 ? 36.83200 -21.45900 22.07500 1.000 24.63941 ? 97  SER A C   1 
ATOM   700  O  O   . SER A 1 103 ? 36.22500 -21.56600 21.00400 1.000 23.16129 ? 97  SER A O   1 
ATOM   701  C  CB  . SER A 1 103 ? 37.79900 -23.76200 22.10900 1.000 25.94624 ? 97  SER A CB  1 
ATOM   702  O  OG  . SER A 1 103 ? 38.92600 -23.23100 21.42700 1.000 27.25182 ? 97  SER A OG  1 
ATOM   703  N  N   . ASP A 1 104 ? 37.32200 -20.31600 22.53300 1.000 25.49072 ? 98  ASP A N   1 
ATOM   704  C  CA  . ASP A 1 104 ? 37.21600 -19.07700 21.72800 1.000 28.14629 ? 98  ASP A CA  1 
ATOM   705  C  C   . ASP A 1 104 ? 38.05100 -19.22700 20.44900 1.000 31.24316 ? 98  ASP A C   1 
ATOM   706  O  O   . ASP A 1 104 ? 37.59800 -18.76900 19.42500 1.000 29.58984 ? 98  ASP A O   1 
ATOM   707  C  CB  . ASP A 1 104 ? 37.63800 -17.86300 22.55100 1.000 34.59035 ? 98  ASP A CB  1 
ATOM   708  C  CG  . ASP A 1 104 ? 36.66200 -17.49200 23.65400 1.000 45.29192 ? 98  ASP A CG  1 
ATOM   709  O  OD1 . ASP A 1 104 ? 35.97500 -18.39100 24.15200 1.000 50.83653 ? 98  ASP A OD1 1 
ATOM   710  O  OD2 . ASP A 1 104 ? 36.61000 -16.31000 24.01200 1.000 45.77299 ? 98  ASP A OD2 1 
ATOM   711  N  N   . ALA A 1 105 ? 39.21200 -19.88100 20.52700 1.000 27.54188 ? 99  ALA A N   1 
ATOM   712  C  CA  . ALA A 1 105 ? 40.03200 -20.06400 19.33200 1.000 27.97767 ? 99  ALA A CA  1 
ATOM   713  C  C   . ALA A 1 105 ? 39.30000 -20.87700 18.27500 1.000 33.25993 ? 99  ALA A C   1 
ATOM   714  O  O   . ALA A 1 105 ? 39.39600 -20.57900 17.07400 1.000 29.16352 ? 99  ALA A O   1 
ATOM   715  C  CB  . ALA A 1 105 ? 41.36100 -20.73000 19.69000 1.000 27.86780 ? 99  ALA A CB  1 
ATOM   716  N  N   . ILE A 1 106 ? 38.56700 -21.91300 18.68900 1.000 22.69833 ? 100 ILE A N   1 
ATOM   717  C  CA  . ILE A 1 106 ? 37.84300 -22.70000 17.69800 1.000 22.12672 ? 100 ILE A CA  1 
ATOM   718  C  C   . ILE A 1 106 ? 36.63400 -21.94100 17.16600 1.000 24.23294 ? 100 ILE A C   1 
ATOM   719  O  O   . ILE A 1 106 ? 36.37500 -21.94200 15.95600 1.000 24.82226 ? 100 ILE A O   1 
ATOM   720  C  CB  . ILE A 1 106 ? 37.43300 -24.05300 18.30000 1.000 22.35340 ? 100 ILE A CB  1 
ATOM   721  C  CG1 . ILE A 1 106 ? 38.67700 -24.93800 18.44000 1.000 27.38163 ? 100 ILE A CG1 1 
ATOM   722  C  CG2 . ILE A 1 106 ? 36.31700 -24.68100 17.48200 1.000 22.06723 ? 100 ILE A CG2 1 
ATOM   723  C  CD1 . ILE A 1 106 ? 38.38900 -26.35100 18.69600 1.000 29.30064 ? 100 ILE A CD1 1 
ATOM   724  N  N   . SER A 1 107 ? 35.85600 -21.29400 18.05000 1.000 23.85268 ? 101 SER A N   1 
ATOM   725  C  CA  A SER A 1 107 ? 34.58500 -20.74300 17.59300 0.653 24.07508 ? 101 SER A CA  1 
ATOM   726  C  CA  B SER A 1 107 ? 34.57500 -20.71100 17.65500 0.347 24.12694 ? 101 SER A CA  1 
ATOM   727  C  C   . SER A 1 107 ? 34.69800 -19.33600 17.01900 1.000 21.36419 ? 101 SER A C   1 
ATOM   728  O  O   . SER A 1 107 ? 33.75700 -18.89600 16.34900 1.000 23.11210 ? 101 SER A O   1 
ATOM   729  C  CB  A SER A 1 107 ? 33.55000 -20.75800 18.73000 0.653 23.02568 ? 101 SER A CB  1 
ATOM   730  C  CB  B SER A 1 107 ? 33.64300 -20.61000 18.86400 0.347 23.13829 ? 101 SER A CB  1 
ATOM   731  O  OG  A SER A 1 107 ? 33.86900 -19.81000 19.72300 0.653 24.30202 ? 101 SER A OG  1 
ATOM   732  O  OG  B SER A 1 107 ? 32.57200 -21.51900 18.73700 0.347 23.82215 ? 101 SER A OG  1 
ATOM   733  N  N   . MET A 1 108 ? 35.81400 -18.63700 17.23800 1.000 24.62433 ? 102 MET A N   1 
ATOM   734  C  CA  . MET A 1 108 ? 36.00400 -17.29000 16.70100 1.000 28.58673 ? 102 MET A CA  1 
ATOM   735  C  C   . MET A 1 108 ? 35.71500 -17.25500 15.20400 1.000 25.28148 ? 102 MET A C   1 
ATOM   736  O  O   . MET A 1 108 ? 36.16100 -18.12800 14.45600 1.000 25.74816 ? 102 MET A O   1 
ATOM   737  C  CB  . MET A 1 108 ? 37.43900 -16.81500 16.95700 1.000 26.26596 ? 102 MET A CB  1 
ATOM   738  C  CG  . MET A 1 108 ? 37.73600 -15.38600 16.50000 1.000 28.14213 ? 102 MET A CG  1 
ATOM   739  S  SD  . MET A 1 108 ? 36.78100 -14.11500 17.36400 1.000 34.38695 ? 102 MET A SD  1 
ATOM   740  C  CE  . MET A 1 108 ? 37.70400 -14.00200 18.89000 1.000 33.69376 ? 102 MET A CE  1 
ATOM   741  N  N   . GLY A 1 109 ? 34.95600 -16.24800 14.77600 1.000 26.19566 ? 103 GLY A N   1 
ATOM   742  C  CA  . GLY A 1 109 ? 34.55900 -16.12100 13.38700 1.000 25.30717 ? 103 GLY A CA  1 
ATOM   743  C  C   . GLY A 1 109 ? 33.27800 -16.83700 13.01400 1.000 32.12062 ? 103 GLY A C   1 
ATOM   744  O  O   . GLY A 1 109 ? 32.86000 -16.75400 11.84900 1.000 27.11516 ? 103 GLY A O   1 
ATOM   745  N  N   . THR A 1 110 ? 32.63200 -17.53000 13.95700 1.000 24.50802 ? 104 THR A N   1 
ATOM   746  C  CA  . THR A 1 110 ? 31.45200 -18.33300 13.66600 1.000 20.05725 ? 104 THR A CA  1 
ATOM   747  C  C   . THR A 1 110 ? 30.34800 -18.00100 14.66200 1.000 24.90175 ? 104 THR A C   1 
ATOM   748  O  O   . THR A 1 110 ? 30.58800 -17.38400 15.70000 1.000 21.07145 ? 104 THR A O   1 
ATOM   749  C  CB  . THR A 1 110 ? 31.72300 -19.85000 13.75400 1.000 26.17945 ? 104 THR A CB  1 
ATOM   750  O  OG1 . THR A 1 110 ? 31.64900 -20.26800 15.13100 1.000 21.09531 ? 104 THR A OG1 1 
ATOM   751  C  CG2 . THR A 1 110 ? 33.08200 -20.22900 13.17900 1.000 21.05688 ? 104 THR A CG2 1 
ATOM   752  N  N   . ARG A 1 111 ? 29.13500 -18.48200 14.35600 1.000 23.02457 ? 105 ARG A N   1 
ATOM   753  C  CA  . ARG A 1 111 ? 27.99600 -18.29700 15.25300 1.000 27.01127 ? 105 ARG A CA  1 
ATOM   754  C  C   . ARG A 1 111 ? 28.17300 -19.03000 16.58100 1.000 22.95987 ? 105 ARG A C   1 
ATOM   755  O  O   . ARG A 1 111 ? 27.52000 -18.67900 17.57300 1.000 22.58510 ? 105 ARG A O   1 
ATOM   756  C  CB  . ARG A 1 111 ? 26.72300 -18.76700 14.55200 1.000 31.72326 ? 105 ARG A CB  1 
ATOM   757  C  CG  . ARG A 1 111 ? 25.44400 -18.32300 15.23300 1.000 38.85309 ? 105 ARG A CG  1 
ATOM   758  C  CD  . ARG A 1 111 ? 25.15900 -16.84300 14.99500 1.000 40.97516 ? 105 ARG A CD  1 
ATOM   759  N  NE  . ARG A 1 111 ? 25.08800 -16.49600 13.57900 1.000 47.23408 ? 105 ARG A NE  1 
ATOM   760  C  CZ  . ARG A 1 111 ? 24.82200 -15.27500 13.13500 1.000 51.89894 ? 105 ARG A CZ  1 
ATOM   761  N  NH1 . ARG A 1 111 ? 24.57400 -14.27600 13.97100 1.000 47.36755 ? 105 ARG A NH1 1 
ATOM   762  N  NH2 . ARG A 1 111 ? 24.79600 -15.05300 11.82200 1.000 54.39054 ? 105 ARG A NH2 1 
ATOM   763  N  N   . GLY A 1 112 ? 29.05300 -20.03000 16.63500 1.000 21.61868 ? 106 GLY A N   1 
ATOM   764  C  CA  . GLY A 1 112 ? 29.35400 -20.65600 17.90900 1.000 22.72200 ? 106 GLY A CA  1 
ATOM   765  C  C   . GLY A 1 112 ? 29.84100 -19.67900 18.96200 1.000 23.13218 ? 106 GLY A C   1 
ATOM   766  O  O   . GLY A 1 112 ? 29.64900 -19.91300 20.16400 1.000 21.07917 ? 106 GLY A O   1 
ATOM   767  N  N   . MET A 1 113 ? 30.46100 -18.56600 18.53700 1.000 21.94303 ? 107 MET A N   1 
ATOM   768  C  CA  . MET A 1 113 ? 30.98100 -17.57500 19.48200 1.000 20.12357 ? 107 MET A CA  1 
ATOM   769  C  C   . MET A 1 113 ? 29.88000 -16.92200 20.31900 1.000 23.11482 ? 107 MET A C   1 
ATOM   770  O  O   . MET A 1 113 ? 30.15900 -16.40600 21.41600 1.000 20.75658 ? 107 MET A O   1 
ATOM   771  C  CB  . MET A 1 113 ? 31.79600 -16.50600 18.72600 1.000 22.65276 ? 107 MET A CB  1 
ATOM   772  C  CG  . MET A 1 113 ? 32.21200 -15.31200 19.58900 1.000 28.67105 ? 107 MET A CG  1 
ATOM   773  S  SD  . MET A 1 113 ? 33.40500 -15.67000 20.92200 1.000 32.47874 ? 107 MET A SD  1 
ATOM   774  C  CE  . MET A 1 113 ? 34.48300 -16.76200 20.03700 1.000 24.54053 ? 107 MET A CE  1 
ATOM   775  N  N   . CYS A 1 114 ? 28.63400 -16.94400 19.84000 1.000 21.05229 ? 108 CYS A N   1 
ATOM   776  C  CA  . CYS A 1 114 ? 27.51900 -16.43600 20.63200 1.000 19.63402 ? 108 CYS A CA  1 
ATOM   777  C  C   . CYS A 1 114 ? 27.32700 -17.21700 21.92100 1.000 21.61429 ? 108 CYS A C   1 
ATOM   778  O  O   . CYS A 1 114 ? 26.64600 -16.73100 22.83600 1.000 20.22150 ? 108 CYS A O   1 
ATOM   779  C  CB  . CYS A 1 114 ? 26.21800 -16.49200 19.83100 1.000 20.84967 ? 108 CYS A CB  1 
ATOM   780  S  SG  . CYS A 1 114 ? 26.24000 -15.45500 18.34500 1.000 24.23453 ? 108 CYS A SG  1 
ATOM   781  N  N   . PHE A 1 115 ? 27.90600 -18.40700 22.01200 1.000 18.78563 ? 109 PHE A N   1 
ATOM   782  C  CA  . PHE A 1 115 ? 27.77600 -19.25600 23.18300 1.000 18.85168 ? 109 PHE A CA  1 
ATOM   783  C  C   . PHE A 1 115 ? 28.94300 -19.11800 24.15500 1.000 23.73254 ? 109 PHE A C   1 
ATOM   784  O  O   . PHE A 1 115 ? 28.93600 -19.77000 25.21100 1.000 21.00907 ? 109 PHE A O   1 
ATOM   785  C  CB  . PHE A 1 115 ? 27.62600 -20.72100 22.73900 1.000 20.88663 ? 109 PHE A CB  1 
ATOM   786  C  CG  . PHE A 1 115 ? 26.35100 -21.00200 21.99600 1.000 21.47568 ? 109 PHE A CG  1 
ATOM   787  C  CD1 . PHE A 1 115 ? 26.21500 -20.67300 20.64500 1.000 21.82590 ? 109 PHE A CD1 1 
ATOM   788  C  CD2 . PHE A 1 115 ? 25.28500 -21.58500 22.64400 1.000 18.56572 ? 109 PHE A CD2 1 
ATOM   789  C  CE1 . PHE A 1 115 ? 25.01800 -20.93100 19.96800 1.000 22.11958 ? 109 PHE A CE1 1 
ATOM   790  C  CE2 . PHE A 1 115 ? 24.09100 -21.84300 21.96700 1.000 19.08105 ? 109 PHE A CE2 1 
ATOM   791  C  CZ  . PHE A 1 115 ? 23.96900 -21.52600 20.62900 1.000 21.63980 ? 109 PHE A CZ  1 
ATOM   792  N  N   . SER A 1 116 ? 29.92300 -18.25500 23.85900 1.000 20.52082 ? 110 SER A N   1 
ATOM   793  C  CA  . SER A 1 116 ? 31.17100 -18.28100 24.61700 1.000 20.59294 ? 110 SER A CA  1 
ATOM   794  C  C   . SER A 1 116 ? 31.09200 -17.50800 25.93900 1.000 19.86002 ? 110 SER A C   1 
ATOM   795  O  O   . SER A 1 116 ? 31.38500 -18.06400 27.00200 1.000 22.67603 ? 110 SER A O   1 
ATOM   796  C  CB  . SER A 1 116 ? 32.32300 -17.75000 23.76400 1.000 24.76380 ? 110 SER A CB  1 
ATOM   797  O  OG  . SER A 1 116 ? 33.45500 -17.55200 24.59200 1.000 23.63695 ? 110 SER A OG  1 
ATOM   798  N  N   . LEU A 1 117 ? 30.72200 -16.22200 25.90900 1.000 19.00822 ? 111 LEU A N   1 
ATOM   799  C  CA  . LEU A 1 117 ? 30.71200 -15.46300 27.16400 1.000 22.58093 ? 111 LEU A CA  1 
ATOM   800  C  C   . LEU A 1 117 ? 29.79800 -16.11500 28.19800 1.000 22.66712 ? 111 LEU A C   1 
ATOM   801  O  O   . LEU A 1 117 ? 30.18600 -16.28200 29.36100 1.000 18.70014 ? 111 LEU A O   1 
ATOM   802  C  CB  . LEU A 1 117 ? 30.28300 -14.01700 26.92900 1.000 19.94176 ? 111 LEU A CB  1 
ATOM   803  C  CG  . LEU A 1 117 ? 30.23100 -13.15700 28.19800 1.000 22.82524 ? 111 LEU A CG  1 
ATOM   804  C  CD1 . LEU A 1 117 ? 31.61600 -13.10600 28.90800 1.000 23.59433 ? 111 LEU A CD1 1 
ATOM   805  C  CD2 . LEU A 1 117 ? 29.71200 -11.76900 27.88800 1.000 22.83951 ? 111 LEU A CD2 1 
ATOM   806  N  N   . GLN A 1 118 ? 28.58200 -16.51600 27.78300 1.000 16.91610 ? 112 GLN A N   1 
ATOM   807  C  CA  . GLN A 1 118 ? 27.60500 -17.06900 28.72800 1.000 19.16530 ? 112 GLN A CA  1 
ATOM   808  C  C   . GLN A 1 118 ? 28.09500 -18.35500 29.38700 1.000 17.60941 ? 112 GLN A C   1 
ATOM   809  O  O   . GLN A 1 118 ? 27.62900 -18.70000 30.48200 1.000 17.06960 ? 112 GLN A O   1 
ATOM   810  C  CB  . GLN A 1 118 ? 26.25700 -17.31600 28.01700 1.000 18.59828 ? 112 GLN A CB  1 
ATOM   811  C  CG  . GLN A 1 118 ? 26.31600 -18.38200 26.90900 1.000 17.39346 ? 112 GLN A CG  1 
ATOM   812  C  CD  . GLN A 1 118 ? 26.02900 -19.79200 27.41700 1.000 23.61162 ? 112 GLN A CD  1 
ATOM   813  O  OE1 . GLN A 1 118 ? 25.35100 -19.98700 28.43900 1.000 20.00184 ? 112 GLN A OE1 1 
ATOM   814  N  NE2 . GLN A 1 118 ? 26.59400 -20.78100 26.74300 1.000 21.21668 ? 112 GLN A NE2 1 
ATOM   815  N  N   . SER A 1 119 ? 29.03300 -19.07000 28.76000 1.000 17.82512 ? 113 SER A N   1 
ATOM   816  C  CA  . SER A 1 119 ? 29.56200 -20.26700 29.39800 1.000 17.78348 ? 113 SER A CA  1 
ATOM   817  C  C   . SER A 1 119 ? 30.28900 -19.93700 30.69500 1.000 19.92226 ? 113 SER A C   1 
ATOM   818  O  O   . SER A 1 119 ? 30.36000 -20.79300 31.58300 1.000 18.14350 ? 113 SER A O   1 
ATOM   819  C  CB  . SER A 1 119 ? 30.45600 -21.04300 28.41200 1.000 17.52218 ? 113 SER A CB  1 
ATOM   820  O  OG  . SER A 1 119 ? 31.75400 -20.48400 28.31700 1.000 19.77412 ? 113 SER A OG  1 
ATOM   821  N  N   . ARG A 1 120 ? 30.80400 -18.71300 30.85000 1.000 15.62617 ? 114 ARG A N   1 
ATOM   822  C  CA  . ARG A 1 120 ? 31.32100 -18.31400 32.16300 1.000 16.77963 ? 114 ARG A CA  1 
ATOM   823  C  C   . ARG A 1 120 ? 30.23600 -18.43700 33.23100 1.000 18.45087 ? 114 ARG A C   1 
ATOM   824  O  O   . ARG A 1 120 ? 30.47000 -18.97000 34.32200 1.000 16.79849 ? 114 ARG A O   1 
ATOM   825  C  CB  . ARG A 1 120 ? 31.85900 -16.88600 32.10100 1.000 16.93390 ? 114 ARG A CB  1 
ATOM   826  C  CG  . ARG A 1 120 ? 32.13200 -16.20900 33.46900 1.000 21.52579 ? 114 ARG A CG  1 
ATOM   827  C  CD  . ARG A 1 120 ? 32.15900 -14.67100 33.31600 1.000 20.62837 ? 114 ARG A CD  1 
ATOM   828  N  NE  . ARG A 1 120 ? 30.82200 -14.07700 33.38400 1.000 19.20264 ? 114 ARG A NE  1 
ATOM   829  C  CZ  . ARG A 1 120 ? 30.59100 -12.77000 33.36400 1.000 21.85458 ? 114 ARG A CZ  1 
ATOM   830  N  NH1 . ARG A 1 120 ? 31.57800 -11.89500 33.21100 1.000 14.49660 ? 114 ARG A NH1 1 
ATOM   831  N  NH2 . ARG A 1 120 ? 29.34300 -12.32800 33.50900 1.000 21.46435 ? 114 ARG A NH2 1 
ATOM   832  N  N   . ASP A 1 121 ? 29.03200 -17.95300 32.93200 1.000 16.55416 ? 115 ASP A N   1 
ATOM   833  C  CA  . ASP A 1 121 ? 27.97800 -17.96700 33.93900 1.000 17.66126 ? 115 ASP A CA  1 
ATOM   834  C  C   . ASP A 1 121 ? 27.35400 -19.34900 34.10100 1.000 19.32566 ? 115 ASP A C   1 
ATOM   835  O  O   . ASP A 1 121 ? 26.86800 -19.68200 35.19200 1.000 20.24219 ? 115 ASP A O   1 
ATOM   836  C  CB  . ASP A 1 121 ? 26.91600 -16.93600 33.57900 1.000 17.92190 ? 115 ASP A CB  1 
ATOM   837  C  CG  . ASP A 1 121 ? 27.52400 -15.62500 33.12500 1.000 20.50203 ? 115 ASP A CG  1 
ATOM   838  O  OD1 . ASP A 1 121 ? 27.86300 -14.80100 33.99100 1.000 19.31105 ? 115 ASP A OD1 1 
ATOM   839  O  OD2 . ASP A 1 121 ? 27.66000 -15.41700 31.90400 1.000 21.53034 ? 115 ASP A OD2 1 
ATOM   840  N  N   . LEU A 1 122 ? 27.34700 -20.15000 33.02900 1.000 16.98130 ? 116 LEU A N   1 
ATOM   841  C  CA  . LEU A 1 122 ? 26.95400 -21.55100 33.13700 1.000 18.17138 ? 116 LEU A CA  1 
ATOM   842  C  C   . LEU A 1 122 ? 27.91300 -22.33000 34.04400 1.000 18.66958 ? 116 LEU A C   1 
ATOM   843  O  O   . LEU A 1 122 ? 27.48200 -23.16800 34.84700 1.000 13.86926 ? 116 LEU A O   1 
ATOM   844  C  CB  . LEU A 1 122 ? 26.91700 -22.16500 31.73900 1.000 18.73987 ? 116 LEU A CB  1 
ATOM   845  C  CG  . LEU A 1 122 ? 26.03500 -23.38100 31.48000 1.000 31.52304 ? 116 LEU A CG  1 
ATOM   846  C  CD1 . LEU A 1 122 ? 24.68000 -23.07700 32.07000 1.000 39.39300 ? 116 LEU A CD1 1 
ATOM   847  C  CD2 . LEU A 1 122 ? 25.89100 -23.64800 29.97700 1.000 19.13552 ? 116 LEU A CD2 1 
ATOM   848  N  N   . ILE A 1 123 ? 29.21700 -22.05000 33.93600 1.000 18.34262 ? 117 ILE A N   1 
ATOM   849  C  CA  . ILE A 1 123 ? 30.20800 -22.70800 34.78800 1.000 15.74458 ? 117 ILE A CA  1 
ATOM   850  C  C   . ILE A 1 123 ? 29.99400 -22.33600 36.25800 1.000 17.60921 ? 117 ILE A C   1 
ATOM   851  O  O   . ILE A 1 123 ? 30.02000 -23.19900 37.14700 1.000 16.91506 ? 117 ILE A O   1 
ATOM   852  C  CB  . ILE A 1 123 ? 31.63100 -22.35100 34.32100 1.000 17.63080 ? 117 ILE A CB  1 
ATOM   853  C  CG1 . ILE A 1 123 ? 31.97300 -23.12700 33.03800 1.000 17.41162 ? 117 ILE A CG1 1 
ATOM   854  C  CG2 . ILE A 1 123 ? 32.65600 -22.58900 35.46800 1.000 16.95848 ? 117 ILE A CG2 1 
ATOM   855  C  CD1 . ILE A 1 123 ? 33.21900 -22.58400 32.29400 1.000 18.03813 ? 117 ILE A CD1 1 
ATOM   856  N  N   . ALA A 1 124 ? 29.77600 -21.04900 36.53200 1.000 15.54910 ? 118 ALA A N   1 
ATOM   857  C  CA  . ALA A 1 124 ? 29.45500 -20.62900 37.89300 1.000 16.32267 ? 118 ALA A CA  1 
ATOM   858  C  C   . ALA A 1 124 ? 28.23200 -21.37300 38.43200 1.000 17.29425 ? 118 ALA A C   1 
ATOM   859  O  O   . ALA A 1 124 ? 28.29000 -21.96300 39.51600 1.000 17.66824 ? 118 ALA A O   1 
ATOM   860  C  CB  . ALA A 1 124 ? 29.25300 -19.11700 37.94000 1.000 16.74335 ? 118 ALA A CB  1 
ATOM   861  N  N   . ASP A 1 125 ? 27.12800 -21.40400 37.66300 1.000 20.14164 ? 119 ASP A N   1 
ATOM   862  C  CA  . ASP A 1 125 ? 25.92700 -22.13600 38.08900 1.000 17.54960 ? 119 ASP A CA  1 
ATOM   863  C  C   . ASP A 1 125 ? 26.21700 -23.60900 38.34900 1.000 17.76422 ? 119 ASP A C   1 
ATOM   864  O  O   . ASP A 1 125 ? 25.64400 -24.21100 39.26800 1.000 17.66106 ? 119 ASP A O   1 
ATOM   865  C  CB  . ASP A 1 125 ? 24.83600 -22.05700 37.02400 1.000 17.07420 ? 119 ASP A CB  1 
ATOM   866  C  CG  . ASP A 1 125 ? 24.22200 -20.68500 36.88400 1.000 18.36718 ? 119 ASP A CG  1 
ATOM   867  O  OD1 . ASP A 1 125 ? 24.33400 -19.83700 37.81000 1.000 18.65064 ? 119 ASP A OD1 1 
ATOM   868  O  OD2 . ASP A 1 125 ? 23.63700 -20.46200 35.80500 1.000 18.04515 ? 119 ASP A OD2 1 
ATOM   869  N  N   . SER A 1 126 ? 27.07200 -24.20900 37.51200 1.000 16.84087 ? 120 SER A N   1 
ATOM   870  C  CA  A SER A 1 126 ? 27.33600 -25.64800 37.58300 0.523 18.49360 ? 120 SER A CA  1 
ATOM   871  C  CA  B SER A 1 126 ? 27.32400 -25.64300 37.58600 0.477 18.31049 ? 120 SER A CA  1 
ATOM   872  C  C   . SER A 1 126 ? 28.08300 -26.01100 38.85600 1.000 18.29835 ? 120 SER A C   1 
ATOM   873  O  O   . SER A 1 126 ? 27.72200 -26.96700 39.55300 1.000 17.78033 ? 120 SER A O   1 
ATOM   874  C  CB  A SER A 1 126 ? 28.14400 -26.10900 36.35800 0.523 18.68904 ? 120 SER A CB  1 
ATOM   875  C  CB  B SER A 1 126 ? 28.08600 -26.07900 36.32900 0.477 18.61577 ? 120 SER A CB  1 
ATOM   876  O  OG  A SER A 1 126 ? 27.39000 -26.00400 35.16500 0.523 19.65132 ? 120 SER A OG  1 
ATOM   877  O  OG  B SER A 1 126 ? 29.36700 -25.48000 36.30600 0.477 18.92890 ? 120 SER A OG  1 
ATOM   878  N  N   . ILE A 1 127 ? 29.14100 -25.26700 39.17100 1.000 17.55313 ? 121 ILE A N   1 
ATOM   879  C  CA  . ILE A 1 127 ? 29.91700 -25.56900 40.37100 1.000 16.58070 ? 121 ILE A CA  1 
ATOM   880  C  C   . ILE A 1 127 ? 29.11800 -25.23800 41.62500 1.000 17.30746 ? 121 ILE A C   1 
ATOM   881  O  O   . ILE A 1 127 ? 29.15700 -25.97900 42.61900 1.000 18.61410 ? 121 ILE A O   1 
ATOM   882  C  CB  . ILE A 1 127 ? 31.25400 -24.81800 40.32000 1.000 18.73659 ? 121 ILE A CB  1 
ATOM   883  C  CG1 . ILE A 1 127 ? 32.09700 -25.36800 39.15500 1.000 20.15143 ? 121 ILE A CG1 1 
ATOM   884  C  CG2 . ILE A 1 127 ? 31.97400 -24.89400 41.68600 1.000 16.99092 ? 121 ILE A CG2 1 
ATOM   885  C  CD1 . ILE A 1 127 ? 33.35300 -24.52100 38.82600 1.000 19.49418 ? 121 ILE A CD1 1 
ATOM   886  N  N   . GLU A 1 128 ? 28.38600 -24.12100 41.60000 1.000 18.73587 ? 122 GLU A N   1 
ATOM   887  C  CA  . GLU A 1 128 ? 27.49300 -23.77700 42.70100 1.000 17.04101 ? 122 GLU A CA  1 
ATOM   888  C  C   . GLU A 1 128 ? 26.51600 -24.91100 42.96100 1.000 19.38488 ? 122 GLU A C   1 
ATOM   889  O  O   . GLU A 1 128 ? 26.31200 -25.32100 44.11000 1.000 17.23956 ? 122 GLU A O   1 
ATOM   890  C  CB  . GLU A 1 128 ? 26.73900 -22.49500 42.37700 1.000 17.88812 ? 122 GLU A CB  1 
ATOM   891  C  CG  . GLU A 1 128 ? 25.69400 -22.13500 43.43500 1.000 16.04073 ? 122 GLU A CG  1 
ATOM   892  C  CD  . GLU A 1 128 ? 24.83600 -20.92800 43.04000 1.000 21.56182 ? 122 GLU A CD  1 
ATOM   893  O  OE1 . GLU A 1 128 ? 24.88800 -20.50900 41.86700 1.000 19.12640 ? 122 GLU A OE1 1 
ATOM   894  O  OE2 . GLU A 1 128 ? 24.08100 -20.41800 43.89200 1.000 22.51752 ? 122 GLU A OE2 1 
ATOM   895  N  N   . THR A 1 129 ? 25.90700 -25.43000 41.88500 1.000 15.76555 ? 123 THR A N   1 
ATOM   896  C  CA  . THR A 1 129 ? 24.91300 -26.49300 42.00800 1.000 17.46867 ? 123 THR A CA  1 
ATOM   897  C  C   . THR A 1 129 ? 25.49400 -27.71400 42.72000 1.000 20.37782 ? 123 THR A C   1 
ATOM   898  O  O   . THR A 1 129 ? 24.89700 -28.22900 43.67800 1.000 18.72134 ? 123 THR A O   1 
ATOM   899  C  CB  . THR A 1 129 ? 24.38500 -26.87200 40.61800 1.000 17.08368 ? 123 THR A CB  1 
ATOM   900  O  OG1 . THR A 1 129 ? 23.58000 -25.80200 40.10500 1.000 17.88506 ? 123 THR A OG1 1 
ATOM   901  C  CG2 . THR A 1 129 ? 23.56200 -28.15900 40.66600 1.000 17.82584 ? 123 THR A CG2 1 
ATOM   902  N  N   . VAL A 1 130 ? 26.66600 -28.18300 42.27300 1.000 16.74721 ? 124 VAL A N   1 
ATOM   903  C  CA  . VAL A 1 130 ? 27.22800 -29.41400 42.81900 1.000 16.74315 ? 124 VAL A CA  1 
ATOM   904  C  C   . VAL A 1 130 ? 27.68000 -29.22400 44.26600 1.000 18.90821 ? 124 VAL A C   1 
ATOM   905  O  O   . VAL A 1 130 ? 27.38600 -30.06300 45.12400 1.000 18.68413 ? 124 VAL A O   1 
ATOM   906  C  CB  . VAL A 1 130 ? 28.37100 -29.92900 41.92300 1.000 18.26580 ? 124 VAL A CB  1 
ATOM   907  C  CG1 . VAL A 1 130 ? 29.02400 -31.16500 42.56500 1.000 17.72503 ? 124 VAL A CG1 1 
ATOM   908  C  CG2 . VAL A 1 130 ? 27.84300 -30.25400 40.52800 1.000 15.26006 ? 124 VAL A CG2 1 
ATOM   909  N  N   . MET A 1 131 ? 28.42100 -28.14500 44.55500 1.000 17.63535 ? 125 MET A N   1 
ATOM   910  C  CA  . MET A 1 131 ? 28.82300 -27.85500 45.93000 1.000 18.32407 ? 125 MET A CA  1 
ATOM   911  C  C   . MET A 1 131 ? 27.62400 -27.78000 46.86900 1.000 20.58803 ? 125 MET A C   1 
ATOM   912  O  O   . MET A 1 131 ? 27.67100 -28.29000 48.00100 1.000 19.84321 ? 125 MET A O   1 
ATOM   913  C  CB  . MET A 1 131 ? 29.60000 -26.53800 45.96400 1.000 14.97765 ? 125 MET A CB  1 
ATOM   914  C  CG  . MET A 1 131 ? 30.97000 -26.47400 45.27800 1.000 15.88830 ? 125 MET A CG  1 
ATOM   915  S  SD  . MET A 1 131 ? 32.20900 -27.50200 46.05400 1.000 20.02285 ? 125 MET A SD  1 
ATOM   916  C  CE  . MET A 1 131 ? 32.45400 -26.50600 47.58600 1.000 20.22317 ? 125 MET A CE  1 
ATOM   917  N  N   . SER A 1 132 ? 26.53400 -27.15800 46.42400 1.000 17.88328 ? 126 SER A N   1 
ATOM   918  C  CA  . SER A 1 132 ? 25.37000 -27.04600 47.30600 1.000 18.27240 ? 126 SER A CA  1 
ATOM   919  C  C   . SER A 1 132 ? 24.69500 -28.40000 47.51200 1.000 19.36688 ? 126 SER A C   1 
ATOM   920  O  O   . SER A 1 132 ? 24.35400 -28.77100 48.64700 1.000 20.17655 ? 126 SER A O   1 
ATOM   921  C  CB  . SER A 1 132 ? 24.36600 -26.02300 46.75600 1.000 18.73658 ? 126 SER A CB  1 
ATOM   922  O  OG  . SER A 1 132 ? 24.95700 -24.72200 46.75300 1.000 19.19646 ? 126 SER A OG  1 
ATOM   923  N  N   . ALA A 1 133 ? 24.47200 -29.14900 46.42400 1.000 17.63106 ? 127 ALA A N   1 
ATOM   924  C  CA  . ALA A 1 133 ? 23.70800 -30.39300 46.54900 1.000 20.45223 ? 127 ALA A CA  1 
ATOM   925  C  C   . ALA A 1 133 ? 24.47200 -31.46900 47.31400 1.000 19.89495 ? 127 ALA A C   1 
ATOM   926  O  O   . ALA A 1 133 ? 23.85700 -32.28700 48.00200 1.000 22.33386 ? 127 ALA A O   1 
ATOM   927  C  CB  . ALA A 1 133 ? 23.32600 -30.93600 45.16800 1.000 20.19110 ? 127 ALA A CB  1 
ATOM   928  N  N   . GLN A 1 134 ? 25.79200 -31.53200 47.16000 1.000 19.69352 ? 128 GLN A N   1 
ATOM   929  C  CA  . GLN A 1 134 ? 26.58600 -32.59900 47.75100 1.000 20.86205 ? 128 GLN A CA  1 
ATOM   930  C  C   . GLN A 1 134 ? 27.18300 -32.21300 49.10900 1.000 24.44606 ? 128 GLN A C   1 
ATOM   931  O  O   . GLN A 1 134 ? 27.85500 -33.04200 49.72500 1.000 20.29426 ? 128 GLN A O   1 
ATOM   932  C  CB  . GLN A 1 134 ? 27.69900 -33.01100 46.78500 1.000 20.39092 ? 128 GLN A CB  1 
ATOM   933  C  CG  . GLN A 1 134 ? 27.23500 -33.25200 45.33100 1.000 16.18753 ? 128 GLN A CG  1 
ATOM   934  C  CD  . GLN A 1 134 ? 26.30400 -34.44800 45.18800 1.000 23.73835 ? 128 GLN A CD  1 
ATOM   935  O  OE1 . GLN A 1 134 ? 25.14200 -34.30300 44.81000 1.000 22.94874 ? 128 GLN A OE1 1 
ATOM   936  N  NE2 . GLN A 1 134 ? 26.80400 -35.62600 45.50300 1.000 26.63582 ? 128 GLN A NE2 1 
ATOM   937  N  N   . TRP A 1 135 ? 26.98300 -30.96700 49.56400 1.000 18.82766 ? 129 TRP A N   1 
ATOM   938  C  CA  . TRP A 1 135 ? 27.40100 -30.51000 50.89500 1.000 22.06696 ? 129 TRP A CA  1 
ATOM   939  C  C   . TRP A 1 135 ? 28.92100 -30.54700 51.08300 1.000 24.44315 ? 129 TRP A C   1 
ATOM   940  O  O   . TRP A 1 135 ? 29.42700 -30.86800 52.16200 1.000 21.24795 ? 129 TRP A O   1 
ATOM   941  C  CB  . TRP A 1 135 ? 26.68100 -31.31900 51.98100 1.000 19.49092 ? 129 TRP A CB  1 
ATOM   942  C  CG  . TRP A 1 135 ? 25.21100 -30.97100 51.99200 1.000 19.21155 ? 129 TRP A CG  1 
ATOM   943  C  CD1 . TRP A 1 135 ? 24.22100 -31.56200 51.26100 1.000 17.85095 ? 129 TRP A CD1 1 
ATOM   944  C  CD2 . TRP A 1 135 ? 24.59200 -29.88600 52.70300 1.000 18.70036 ? 129 TRP A CD2 1 
ATOM   945  N  NE1 . TRP A 1 135 ? 23.02200 -30.93100 51.49700 1.000 21.85516 ? 129 TRP A NE1 1 
ATOM   946  C  CE2 . TRP A 1 135 ? 23.22200 -29.90300 52.38200 1.000 21.93887 ? 129 TRP A CE2 1 
ATOM   947  C  CE3 . TRP A 1 135 ? 25.06100 -28.92100 53.59900 1.000 20.92360 ? 129 TRP A CE3 1 
ATOM   948  C  CZ2 . TRP A 1 135 ? 22.31500 -28.99200 52.92800 1.000 21.40881 ? 129 TRP A CZ2 1 
ATOM   949  C  CZ3 . TRP A 1 135 ? 24.15400 -28.01000 54.13100 1.000 19.74825 ? 129 TRP A CZ3 1 
ATOM   950  C  CH2 . TRP A 1 135 ? 22.80600 -28.05100 53.79200 1.000 23.70119 ? 129 TRP A CH2 1 
ATOM   951  N  N   . TYR A 1 136 ? 29.66500 -30.19200 50.04000 1.000 17.96888 ? 130 TYR A N   1 
ATOM   952  C  CA  . TYR A 1 136 ? 31.11500 -30.19500 50.15800 1.000 21.61177 ? 130 TYR A CA  1 
ATOM   953  C  C   . TYR A 1 136 ? 31.59000 -28.99200 50.98000 1.000 20.85771 ? 130 TYR A C   1 
ATOM   954  O  O   . TYR A 1 136 ? 31.02000 -27.90400 50.90700 1.000 20.07361 ? 130 TYR A O   1 
ATOM   955  C  CB  . TYR A 1 136 ? 31.77400 -30.17100 48.77200 1.000 21.90443 ? 130 TYR A CB  1 
ATOM   956  C  CG  . TYR A 1 136 ? 31.50300 -31.39600 47.91100 1.000 21.31727 ? 130 TYR A CG  1 
ATOM   957  C  CD1 . TYR A 1 136 ? 31.31900 -32.65900 48.49500 1.000 20.90142 ? 130 TYR A CD1 1 
ATOM   958  C  CD2 . TYR A 1 136 ? 31.44800 -31.29900 46.50400 1.000 21.30720 ? 130 TYR A CD2 1 
ATOM   959  C  CE1 . TYR A 1 136 ? 31.06600 -33.78100 47.72400 1.000 18.58093 ? 130 TYR A CE1 1 
ATOM   960  C  CE2 . TYR A 1 136 ? 31.19600 -32.43700 45.71000 1.000 19.97824 ? 130 TYR A CE2 1 
ATOM   961  C  CZ  . TYR A 1 136 ? 31.01100 -33.67800 46.33200 1.000 24.00336 ? 130 TYR A CZ  1 
ATOM   962  O  OH  . TYR A 1 136 ? 30.75400 -34.82400 45.58100 1.000 20.48810 ? 130 TYR A OH  1 
ATOM   963  N  N   . ASP A 1 137 ? 32.68600 -29.19500 51.72400 1.000 19.37199 ? 131 ASP A N   1 
ATOM   964  C  CA  . ASP A 1 137 ? 33.20500 -28.19700 52.66000 1.000 22.48996 ? 131 ASP A CA  1 
ATOM   965  C  C   . ASP A 1 137 ? 34.08500 -27.14800 51.99500 1.000 21.65895 ? 131 ASP A C   1 
ATOM   966  O  O   . ASP A 1 137 ? 34.19100 -26.02200 52.50300 1.000 20.44845 ? 131 ASP A O   1 
ATOM   967  C  CB  . ASP A 1 137 ? 34.01300 -28.88600 53.76600 1.000 21.56733 ? 131 ASP A CB  1 
ATOM   968  C  CG  . ASP A 1 137 ? 33.19500 -29.91400 54.51700 1.000 21.26235 ? 131 ASP A CG  1 
ATOM   969  O  OD1 . ASP A 1 137 ? 32.16000 -29.53200 55.10700 1.000 24.19162 ? 131 ASP A OD1 1 
ATOM   970  O  OD2 . ASP A 1 137 ? 33.57500 -31.10200 54.48400 1.000 20.40073 ? 131 ASP A OD2 1 
ATOM   971  N  N   . GLY A 1 138 ? 34.74900 -27.50200 50.89900 1.000 20.20198 ? 132 GLY A N   1 
ATOM   972  C  CA  . GLY A 1 138 ? 35.69400 -26.61200 50.25100 1.000 21.84979 ? 132 GLY A CA  1 
ATOM   973  C  C   . GLY A 1 138 ? 35.77700 -26.95800 48.78000 1.000 17.98896 ? 132 GLY A C   1 
ATOM   974  O  O   . GLY A 1 138 ? 35.22500 -27.95900 48.33200 1.000 19.93516 ? 132 GLY A O   1 
ATOM   975  N  N   . ASN A 1 139 ? 36.47400 -26.11700 48.02400 1.000 19.35147 ? 133 ASN A N   1 
ATOM   976  C  CA  . ASN A 1 139 ? 36.54500 -26.29700 46.58100 1.000 23.51973 ? 133 ASN A CA  1 
ATOM   977  C  C   . ASN A 1 139 ? 37.95700 -26.04700 46.07600 1.000 20.80257 ? 133 ASN A C   1 
ATOM   978  O  O   . ASN A 1 139 ? 38.63600 -25.11600 46.52500 1.000 21.58387 ? 133 ASN A O   1 
ATOM   979  C  CB  . ASN A 1 139 ? 35.57000 -25.35100 45.86700 1.000 20.67590 ? 133 ASN A CB  1 
ATOM   980  C  CG  . ASN A 1 139 ? 35.68100 -25.43000 44.35600 1.000 18.06413 ? 133 ASN A CG  1 
ATOM   981  O  OD1 . ASN A 1 139 ? 36.43600 -24.68100 43.73200 1.000 20.75922 ? 133 ASN A OD1 1 
ATOM   982  N  ND2 . ASN A 1 139 ? 34.92500 -26.34500 43.75600 1.000 21.81395 ? 133 ASN A ND2 1 
ATOM   983  N  N   . ILE A 1 140 ? 38.40400 -26.88400 45.14600 1.000 17.94437 ? 134 ILE A N   1 
ATOM   984  C  CA  . ILE A 1 140 ? 39.57600 -26.57100 44.33700 1.000 17.40799 ? 134 ILE A CA  1 
ATOM   985  C  C   . ILE A 1 140 ? 39.14400 -26.65800 42.88200 1.000 18.87124 ? 134 ILE A C   1 
ATOM   986  O  O   . ILE A 1 140 ? 38.67200 -27.71000 42.43800 1.000 20.54613 ? 134 ILE A O   1 
ATOM   987  C  CB  . ILE A 1 140 ? 40.75700 -27.51500 44.61400 1.000 20.59021 ? 134 ILE A CB  1 
ATOM   988  C  CG1 . ILE A 1 140 ? 41.19200 -27.41100 46.07900 1.000 22.01802 ? 134 ILE A CG1 1 
ATOM   989  C  CG2 . ILE A 1 140 ? 41.91700 -27.15500 43.72700 1.000 21.37331 ? 134 ILE A CG2 1 
ATOM   990  C  CD1 . ILE A 1 140 ? 42.13200 -28.54000 46.52400 1.000 21.66112 ? 134 ILE A CD1 1 
ATOM   991  N  N   . SER A 1 141 ? 39.29700 -25.56300 42.14200 1.000 20.58241 ? 135 SER A N   1 
ATOM   992  C  CA  . SER A 1 141 ? 38.86900 -25.51700 40.74900 1.000 23.97685 ? 135 SER A CA  1 
ATOM   993  C  C   . SER A 1 141 ? 40.08500 -25.50100 39.83900 1.000 20.84587 ? 135 SER A C   1 
ATOM   994  O  O   . SER A 1 141 ? 41.09300 -24.84900 40.14300 1.000 19.39769 ? 135 SER A O   1 
ATOM   995  C  CB  . SER A 1 141 ? 37.98500 -24.29400 40.45300 1.000 20.25909 ? 135 SER A CB  1 
ATOM   996  O  OG  . SER A 1 141 ? 36.68600 -24.45400 41.01400 1.000 19.01975 ? 135 SER A OG  1 
ATOM   997  N  N   . ILE A 1 142 ? 39.97000 -26.20700 38.71800 1.000 20.57125 ? 136 ILE A N   1 
ATOM   998  C  CA  . ILE A 1 142 ? 41.04700 -26.26300 37.73800 1.000 19.43079 ? 136 ILE A CA  1 
ATOM   999  C  C   . ILE A 1 142 ? 40.50400 -25.80300 36.39100 1.000 21.35215 ? 136 ILE A C   1 
ATOM   1000 O  O   . ILE A 1 142 ? 40.13900 -26.63000 35.53800 1.000 20.91624 ? 136 ILE A O   1 
ATOM   1001 C  CB  . ILE A 1 142 ? 41.66100 -27.66700 37.65300 1.000 22.64058 ? 136 ILE A CB  1 
ATOM   1002 C  CG1 . ILE A 1 142 ? 41.99600 -28.17000 39.05400 1.000 20.91201 ? 136 ILE A CG1 1 
ATOM   1003 C  CG2 . ILE A 1 142 ? 42.91900 -27.63100 36.81500 1.000 22.80371 ? 136 ILE A CG2 1 
ATOM   1004 C  CD1 . ILE A 1 142 ? 41.48900 -29.54000 39.34700 1.000 30.56932 ? 136 ILE A CD1 1 
ATOM   1005 N  N   . PRO A 1 143 ? 40.41700 -24.50100 36.17100 1.000 19.79337 ? 137 PRO A N   1 
ATOM   1006 C  CA  . PRO A 1 143 ? 40.04400 -23.98900 34.85600 1.000 23.79804 ? 137 PRO A CA  1 
ATOM   1007 C  C   . PRO A 1 143 ? 41.27700 -24.00000 33.95900 1.000 25.48608 ? 137 PRO A C   1 
ATOM   1008 O  O   . PRO A 1 143 ? 42.40400 -24.12200 34.43000 1.000 28.30586 ? 137 PRO A O   1 
ATOM   1009 C  CB  . PRO A 1 143 ? 39.59700 -22.56700 35.17700 1.000 21.46489 ? 137 PRO A CB  1 
ATOM   1010 C  CG  . PRO A 1 143 ? 40.58500 -22.17800 36.28400 1.000 20.40533 ? 137 PRO A CG  1 
ATOM   1011 C  CD  . PRO A 1 143 ? 40.66700 -23.41700 37.13900 1.000 18.21585 ? 137 PRO A CD  1 
ATOM   1012 N  N   . GLY A 1 144 ? 41.06300 -23.86500 32.65600 1.000 28.83074 ? 138 GLY A N   1 
ATOM   1013 C  CA  . GLY A 1 144 ? 42.23800 -23.71900 31.80700 1.000 32.81006 ? 138 GLY A CA  1 
ATOM   1014 C  C   . GLY A 1 144 ? 42.17900 -22.64900 30.72600 1.000 31.60362 ? 138 GLY A C   1 
ATOM   1015 O  O   . GLY A 1 144 ? 43.14500 -22.46400 29.97400 1.000 34.51939 ? 138 GLY A O   1 
ATOM   1016 N  N   . CYS A 1 145 ? 41.04800 -21.95800 30.61100 1.000 35.75654 ? 139 CYS A N   1 
ATOM   1017 C  CA  . CYS A 1 145 ? 40.72800 -21.23600 29.38300 1.000 32.39063 ? 139 CYS A CA  1 
ATOM   1018 C  C   . CYS A 1 145 ? 39.88800 -20.02500 29.74800 1.000 39.54139 ? 139 CYS A C   1 
ATOM   1019 O  O   . CYS A 1 145 ? 39.18300 -20.03700 30.76300 1.000 35.85492 ? 139 CYS A O   1 
ATOM   1020 C  CB  . CYS A 1 145 ? 39.98200 -22.16400 28.39600 1.000 35.88204 ? 139 CYS A CB  1 
ATOM   1021 S  SG  . CYS A 1 145 ? 39.36900 -21.42900 26.81800 1.000 36.36621 ? 139 CYS A SG  1 
ATOM   1022 N  N   . ASP A 1 146 ? 40.02400 -18.96800 28.94900 1.000 37.65770 ? 140 ASP A N   1 
ATOM   1023 C  CA  . ASP A 1 146 ? 39.36000 -17.64700 29.14200 1.000 38.88995 ? 140 ASP A CA  1 
ATOM   1024 C  C   . ASP A 1 146 ? 38.23900 -17.55800 30.16300 1.000 35.54015 ? 140 ASP A C   1 
ATOM   1025 O  O   . ASP A 1 146 ? 38.51100 -17.15900 31.28700 1.000 36.61643 ? 140 ASP A O   1 
ATOM   1026 C  CB  . ASP A 1 146 ? 38.76500 -17.15800 27.81500 1.000 38.84931 ? 140 ASP A CB  1 
ATOM   1027 C  CG  . ASP A 1 146 ? 39.80100 -16.67100 26.82600 1.000 48.69138 ? 140 ASP A CG  1 
ATOM   1028 O  OD1 . ASP A 1 146 ? 40.93800 -16.46700 27.25000 1.000 47.31381 ? 140 ASP A OD1 1 
ATOM   1029 O  OD2 . ASP A 1 146 ? 39.45500 -16.49900 25.64900 1.000 53.48351 ? 140 ASP A OD2 1 
ATOM   1030 N  N   . LYS A 1 147 ? 37.03200 -17.89700 29.74400 1.000 33.03289 ? 141 LYS A N   1 
ATOM   1031 C  CA  . LYS A 1 147 ? 35.88000 -17.65900 30.60200 1.000 35.81748 ? 141 LYS A CA  1 
ATOM   1032 C  C   . LYS A 1 147 ? 35.83700 -18.62600 31.78400 1.000 31.89349 ? 141 LYS A C   1 
ATOM   1033 O  O   . LYS A 1 147 ? 35.17100 -18.33600 32.78400 1.000 30.09587 ? 141 LYS A O   1 
ATOM   1034 C  CB  . LYS A 1 147 ? 34.56500 -17.75600 29.77800 1.000 23.06824 ? 141 LYS A CB  1 
ATOM   1035 C  CG  . LYS A 1 147 ? 34.55500 -17.03200 28.40100 1.000 32.69473 ? 141 LYS A CG  1 
ATOM   1036 C  CD  . LYS A 1 147 ? 34.83100 -15.51300 28.54300 1.000 41.84730 ? 141 LYS A CD  1 
ATOM   1037 C  CE  . LYS A 1 147 ? 35.43800 -14.84700 27.26000 1.000 40.91547 ? 141 LYS A CE  1 
ATOM   1038 N  NZ  . LYS A 1 147 ? 36.20000 -13.55400 27.59500 1.000 37.18616 ? 141 LYS A NZ  1 
ATOM   1039 N  N   . ASN A 1 148 ? 36.51200 -19.77000 31.69100 1.000 30.28767 ? 142 ASN A N   1 
ATOM   1040 C  CA  . ASN A 1 148 ? 36.46000 -20.72900 32.79100 1.000 27.38453 ? 142 ASN A CA  1 
ATOM   1041 C  C   . ASN A 1 148 ? 36.84800 -20.07700 34.10400 1.000 29.61799 ? 142 ASN A C   1 
ATOM   1042 O  O   . ASN A 1 148 ? 36.22500 -20.32200 35.14800 1.000 27.62345 ? 142 ASN A O   1 
ATOM   1043 C  CB  . ASN A 1 148 ? 37.42100 -21.88100 32.58000 1.000 26.94194 ? 142 ASN A CB  1 
ATOM   1044 C  CG  . ASN A 1 148 ? 37.31600 -22.53600 31.25400 1.000 36.09298 ? 142 ASN A CG  1 
ATOM   1045 O  OD1 . ASN A 1 148 ? 36.39800 -22.28300 30.42500 1.000 23.06171 ? 142 ASN A OD1 1 
ATOM   1046 N  ND2 . ASN A 1 148 ? 38.30900 -23.40900 31.01300 1.000 24.56081 ? 142 ASN A ND2 1 
ATOM   1047 N  N   . MET A 1 149 ? 37.94100 -19.30700 34.08100 1.000 25.15715 ? 143 MET A N   1 
ATOM   1048 C  CA  A MET A 1 149 ? 38.50200 -18.77000 35.31800 0.545 24.65813 ? 143 MET A CA  1 
ATOM   1049 C  CA  B MET A 1 149 ? 38.49200 -18.77800 35.32500 0.455 24.62971 ? 143 MET A CA  1 
ATOM   1050 C  C   . MET A 1 149 ? 37.48600 -17.93600 36.09400 1.000 23.80467 ? 143 MET A C   1 
ATOM   1051 O  O   . MET A 1 149 ? 37.14400 -18.30800 37.23200 1.000 22.38874 ? 143 MET A O   1 
ATOM   1052 C  CB  A MET A 1 149 ? 39.78300 -17.98600 35.00100 0.545 22.58292 ? 143 MET A CB  1 
ATOM   1053 C  CB  B MET A 1 149 ? 39.77800 -18.00200 35.04700 0.455 23.17008 ? 143 MET A CB  1 
ATOM   1054 C  CG  A MET A 1 149 ? 41.04900 -18.81400 35.04300 0.545 24.71274 ? 143 MET A CG  1 
ATOM   1055 C  CG  B MET A 1 149 ? 41.00000 -18.83400 35.20200 0.455 24.77016 ? 143 MET A CG  1 
ATOM   1056 S  SD  A MET A 1 149 ? 41.26200 -19.76300 33.53800 0.545 24.19404 ? 143 MET A SD  1 
ATOM   1057 S  SD  B MET A 1 149 ? 42.35700 -17.97900 34.46600 0.455 26.16366 ? 143 MET A SD  1 
ATOM   1058 C  CE  A MET A 1 149 ? 41.61100 -18.43100 32.38400 0.545 26.97390 ? 143 MET A CE  1 
ATOM   1059 C  CE  B MET A 1 149 ? 41.98400 -18.25700 32.72700 0.455 27.23375 ? 143 MET A CE  1 
ATOM   1060 N  N   . PRO A 1 150 ? 36.97600 -16.81200 35.57000 1.000 20.17726 ? 144 PRO A N   1 
ATOM   1061 C  CA  . PRO A 1 150 ? 36.00700 -16.05800 36.38900 1.000 19.48236 ? 144 PRO A CA  1 
ATOM   1062 C  C   . PRO A 1 150 ? 34.77700 -16.87500 36.74500 1.000 18.02761 ? 144 PRO A C   1 
ATOM   1063 O  O   . PRO A 1 150 ? 34.21000 -16.68100 37.82900 1.000 20.34033 ? 144 PRO A O   1 
ATOM   1064 C  CB  . PRO A 1 150 ? 35.65600 -14.84200 35.51500 1.000 17.97186 ? 144 PRO A CB  1 
ATOM   1065 C  CG  . PRO A 1 150 ? 35.99000 -15.25100 34.13700 1.000 24.68501 ? 144 PRO A CG  1 
ATOM   1066 C  CD  . PRO A 1 150 ? 37.15500 -16.18300 34.23800 1.000 22.48545 ? 144 PRO A CD  1 
ATOM   1067 N  N   . GLY A 1 151 ? 34.36400 -17.79800 35.87500 1.000 19.12763 ? 145 GLY A N   1 
ATOM   1068 C  CA  . GLY A 1 151 ? 33.25900 -18.68200 36.21600 1.000 18.59093 ? 145 GLY A CA  1 
ATOM   1069 C  C   . GLY A 1 151 ? 33.49300 -19.44000 37.50700 1.000 19.60074 ? 145 GLY A C   1 
ATOM   1070 O  O   . GLY A 1 151 ? 32.59500 -19.54500 38.35000 1.000 21.32661 ? 145 GLY A O   1 
ATOM   1071 N  N   . THR A 1 152 ? 34.70900 -19.95700 37.70800 1.000 18.13662 ? 146 THR A N   1 
ATOM   1072 C  CA  . THR A 1 152 ? 34.93900 -20.69900 38.95100 1.000 16.72019 ? 146 THR A CA  1 
ATOM   1073 C  C   . THR A 1 152 ? 34.96500 -19.76700 40.16000 1.000 19.44255 ? 146 THR A C   1 
ATOM   1074 O  O   . THR A 1 152 ? 34.48100 -20.14000 41.23800 1.000 17.86972 ? 146 THR A O   1 
ATOM   1075 C  CB  . THR A 1 152 ? 36.22900 -21.52400 38.87400 1.000 16.46354 ? 146 THR A CB  1 
ATOM   1076 O  OG1 . THR A 1 152 ? 37.37200 -20.66200 38.84800 1.000 18.92324 ? 146 THR A OG1 1 
ATOM   1077 C  CG2 . THR A 1 152 ? 36.22500 -22.42400 37.60000 1.000 16.04452 ? 146 THR A CG2 1 
ATOM   1078 N  N   . ILE A 1 153 ? 35.51000 -18.54500 40.01000 1.000 18.64415 ? 147 ILE A N   1 
ATOM   1079 C  CA  . ILE A 1 153 ? 35.58700 -17.63600 41.16000 1.000 18.68002 ? 147 ILE A CA  1 
ATOM   1080 C  C   . ILE A 1 153 ? 34.18900 -17.16400 41.56500 1.000 18.04062 ? 147 ILE A C   1 
ATOM   1081 O  O   . ILE A 1 153 ? 33.87600 -17.05000 42.76100 1.000 18.84709 ? 147 ILE A O   1 
ATOM   1082 C  CB  . ILE A 1 153 ? 36.52000 -16.44100 40.86300 1.000 13.84234 ? 147 ILE A CB  1 
ATOM   1083 C  CG1 . ILE A 1 153 ? 37.93600 -16.91700 40.50300 1.000 16.73177 ? 147 ILE A CG1 1 
ATOM   1084 C  CG2 . ILE A 1 153 ? 36.52500 -15.42300 42.05400 1.000 17.22976 ? 147 ILE A CG2 1 
ATOM   1085 C  CD1 . ILE A 1 153 ? 38.65600 -17.70400 41.61300 1.000 19.32434 ? 147 ILE A CD1 1 
ATOM   1086 N  N   . MET A 1 154 ? 33.32700 -16.88800 40.57800 1.000 17.12067 ? 148 MET A N   1 
ATOM   1087 C  CA  . MET A 1 154 ? 31.95100 -16.48100 40.86600 1.000 17.20254 ? 148 MET A CA  1 
ATOM   1088 C  C   . MET A 1 154 ? 31.22300 -17.53300 41.69100 1.000 18.51828 ? 148 MET A C   1 
ATOM   1089 O  O   . MET A 1 154 ? 30.49400 -17.19900 42.64100 1.000 17.76637 ? 148 MET A O   1 
ATOM   1090 C  CB  . MET A 1 154 ? 31.20200 -16.20400 39.55700 1.000 12.87355 ? 148 MET A CB  1 
ATOM   1091 C  CG  . MET A 1 154 ? 31.82000 -15.04600 38.75600 1.000 16.17894 ? 148 MET A CG  1 
ATOM   1092 S  SD  . MET A 1 154 ? 31.28900 -15.03400 37.02500 1.000 20.72152 ? 148 MET A SD  1 
ATOM   1093 C  CE  . MET A 1 154 ? 29.49900 -15.01800 37.13100 1.000 19.10706 ? 148 MET A CE  1 
ATOM   1094 N  N   . ALA A 1 155 ? 31.40300 -18.81200 41.34200 1.000 17.05352 ? 149 ALA A N   1 
ATOM   1095 C  CA  . ALA A 1 155 ? 30.79900 -19.87500 42.14400 1.000 17.92861 ? 149 ALA A CA  1 
ATOM   1096 C  C   . ALA A 1 155 ? 31.34500 -19.86600 43.56800 1.000 19.40417 ? 149 ALA A C   1 
ATOM   1097 O  O   . ALA A 1 155 ? 30.58500 -20.02300 44.52900 1.000 21.94184 ? 149 ALA A O   1 
ATOM   1098 C  CB  . ALA A 1 155 ? 31.04000 -21.24100 41.49300 1.000 15.22234 ? 149 ALA A CB  1 
ATOM   1099 N  N   . MET A 1 156 ? 32.66600 -19.70500 43.72200 1.000 19.56452 ? 150 MET A N   1 
ATOM   1100 C  CA  . MET A 1 156 ? 33.25400 -19.62700 45.05400 1.000 19.03908 ? 150 MET A CA  1 
ATOM   1101 C  C   . MET A 1 156 ? 32.69800 -18.44700 45.84300 1.000 21.15197 ? 150 MET A C   1 
ATOM   1102 O  O   . MET A 1 156 ? 32.50000 -18.54900 47.06100 1.000 21.20778 ? 150 MET A O   1 
ATOM   1103 C  CB  . MET A 1 156 ? 34.77600 -19.51800 44.94000 1.000 22.75749 ? 150 MET A CB  1 
ATOM   1104 C  CG  . MET A 1 156 ? 35.48700 -20.79200 44.44600 1.000 19.29099 ? 150 MET A CG  1 
ATOM   1105 S  SD  . MET A 1 156 ? 37.27200 -20.47800 44.36400 1.000 21.99767 ? 150 MET A SD  1 
ATOM   1106 C  CE  . MET A 1 156 ? 37.79700 -21.71800 43.14000 1.000 18.99502 ? 150 MET A CE  1 
ATOM   1107 N  N   . GLY A 1 157 ? 32.45100 -17.31600 45.17300 1.000 19.72411 ? 151 GLY A N   1 
ATOM   1108 C  CA  . GLY A 1 157 ? 31.90600 -16.16100 45.87000 1.000 19.64213 ? 151 GLY A CA  1 
ATOM   1109 C  C   . GLY A 1 157 ? 30.47700 -16.36500 46.34800 1.000 18.08739 ? 151 GLY A C   1 
ATOM   1110 O  O   . GLY A 1 157 ? 30.12700 -15.98000 47.46700 1.000 20.70076 ? 151 GLY A O   1 
ATOM   1111 N  N   . ARG A 1 158 ? 29.64300 -16.99400 45.51900 1.000 19.27111 ? 152 ARG A N   1 
ATOM   1112 C  CA  . ARG A 1 158 ? 28.26600 -17.28900 45.90900 1.000 20.67882 ? 152 ARG A CA  1 
ATOM   1113 C  C   . ARG A 1 158 ? 28.21800 -18.24200 47.09900 1.000 19.96480 ? 152 ARG A C   1 
ATOM   1114 O  O   . ARG A 1 158 ? 27.43300 -18.03500 48.03500 1.000 20.81079 ? 152 ARG A O   1 
ATOM   1115 C  CB  . ARG A 1 158 ? 27.50300 -17.89400 44.73100 1.000 20.97637 ? 152 ARG A CB  1 
ATOM   1116 C  CG  . ARG A 1 158 ? 27.36500 -16.97300 43.50000 1.000 19.36950 ? 152 ARG A CG  1 
ATOM   1117 C  CD  . ARG A 1 158 ? 26.84700 -17.77800 42.32400 1.000 19.20985 ? 152 ARG A CD  1 
ATOM   1118 N  NE  . ARG A 1 158 ? 26.72200 -16.98500 41.09800 1.000 21.50407 ? 152 ARG A NE  1 
ATOM   1119 C  CZ  . ARG A 1 158 ? 26.27800 -17.48700 39.95600 1.000 20.59235 ? 152 ARG A CZ  1 
ATOM   1120 N  NH1 . ARG A 1 158 ? 25.90300 -18.75500 39.86700 1.000 18.88905 ? 152 ARG A NH1 1 
ATOM   1121 N  NH2 . ARG A 1 158 ? 26.21000 -16.70500 38.88000 1.000 17.73017 ? 152 ARG A NH2 1 
ATOM   1122 N  N   . LEU A 1 159 ? 29.03800 -19.29800 47.06900 1.000 21.09577 ? 153 LEU A N   1 
ATOM   1123 C  CA  . LEU A 1 159 ? 29.04600 -20.30000 48.13500 1.000 18.52651 ? 153 LEU A CA  1 
ATOM   1124 C  C   . LEU A 1 159 ? 29.71600 -19.77900 49.40000 1.000 20.85241 ? 153 LEU A C   1 
ATOM   1125 O  O   . LEU A 1 159 ? 29.33100 -20.14900 50.52200 1.000 21.80547 ? 153 LEU A O   1 
ATOM   1126 C  CB  . LEU A 1 159 ? 29.79200 -21.54500 47.66000 1.000 16.30615 ? 153 LEU A CB  1 
ATOM   1127 C  CG  . LEU A 1 159 ? 29.12900 -22.34100 46.54400 1.000 15.49107 ? 153 LEU A CG  1 
ATOM   1128 C  CD1 . LEU A 1 159 ? 30.21900 -23.07800 45.77300 1.000 14.21172 ? 153 LEU A CD1 1 
ATOM   1129 C  CD2 . LEU A 1 159 ? 28.13100 -23.30800 47.14100 1.000 17.13813 ? 153 LEU A CD2 1 
ATOM   1130 N  N   . ASN A 1 160 ? 30.75500 -18.96700 49.23500 1.000 19.56186 ? 154 ASN A N   1 
ATOM   1131 C  CA  . ASN A 1 160 ? 31.57200 -18.48000 50.34000 1.000 21.86187 ? 154 ASN A CA  1 
ATOM   1132 C  C   . ASN A 1 160 ? 32.10200 -19.62000 51.20800 1.000 26.20909 ? 154 ASN A C   1 
ATOM   1133 O  O   . ASN A 1 160 ? 32.11500 -19.53600 52.44200 1.000 21.91146 ? 154 ASN A O   1 
ATOM   1134 C  CB  . ASN A 1 160 ? 30.82200 -17.46900 51.20400 1.000 21.13513 ? 154 ASN A CB  1 
ATOM   1135 C  CG  . ASN A 1 160 ? 31.78900 -16.61200 52.01300 1.000 29.40847 ? 154 ASN A CG  1 
ATOM   1136 O  OD1 . ASN A 1 160 ? 32.91900 -16.38000 51.57500 1.000 21.71177 ? 154 ASN A OD1 1 
ATOM   1137 N  ND2 . ASN A 1 160 ? 31.37400 -16.17800 53.19900 1.000 26.84769 ? 154 ASN A ND2 1 
ATOM   1138 N  N   . ARG A 1 161 ? 32.54100 -20.70600 50.54900 1.000 23.35736 ? 155 ARG A N   1 
ATOM   1139 C  CA  . ARG A 1 161 ? 33.25100 -21.78600 51.20900 1.000 20.65532 ? 155 ARG A CA  1 
ATOM   1140 C  C   . ARG A 1 161 ? 34.71200 -21.74300 50.79100 1.000 21.65056 ? 155 ARG A C   1 
ATOM   1141 O  O   . ARG A 1 161 ? 35.01300 -21.34300 49.66100 1.000 21.54740 ? 155 ARG A O   1 
ATOM   1142 C  CB  . ARG A 1 161 ? 32.64400 -23.14900 50.84900 1.000 19.95826 ? 155 ARG A CB  1 
ATOM   1143 C  CG  . ARG A 1 161 ? 31.16400 -23.25900 51.25200 1.000 20.56508 ? 155 ARG A CG  1 
ATOM   1144 C  CD  . ARG A 1 161 ? 30.45400 -24.52500 50.69200 1.000 19.78299 ? 155 ARG A CD  1 
ATOM   1145 N  NE  . ARG A 1 161 ? 29.00000 -24.38300 50.78200 1.000 20.27896 ? 155 ARG A NE  1 
ATOM   1146 C  CZ  . ARG A 1 161 ? 28.12400 -25.35100 50.53100 1.000 21.16755 ? 155 ARG A CZ  1 
ATOM   1147 N  NH1 . ARG A 1 161 ? 28.51700 -26.57900 50.21700 1.000 20.07610 ? 155 ARG A NH1 1 
ATOM   1148 N  NH2 . ARG A 1 161 ? 26.82100 -25.07500 50.58400 1.000 19.24531 ? 155 ARG A NH2 1 
ATOM   1149 N  N   . PRO A 1 162 ? 35.63000 -22.10200 51.67600 1.000 22.27141 ? 156 PRO A N   1 
ATOM   1150 C  CA  . PRO A 1 162 ? 37.05900 -22.01200 51.34300 1.000 24.47784 ? 156 PRO A CA  1 
ATOM   1151 C  C   . PRO A 1 162 ? 37.37100 -22.65000 49.99600 1.000 24.11009 ? 156 PRO A C   1 
ATOM   1152 O  O   . PRO A 1 162 ? 36.90400 -23.74700 49.68000 1.000 22.28856 ? 156 PRO A O   1 
ATOM   1153 C  CB  . PRO A 1 162 ? 37.72600 -22.75800 52.50000 1.000 22.56357 ? 156 PRO A CB  1 
ATOM   1154 C  CG  . PRO A 1 162 ? 36.78700 -22.41700 53.70500 1.000 22.79676 ? 156 PRO A CG  1 
ATOM   1155 C  CD  . PRO A 1 162 ? 35.40100 -22.51600 53.07900 1.000 22.37681 ? 156 PRO A CD  1 
ATOM   1156 N  N   . GLY A 1 163 ? 38.16000 -21.94500 49.19000 1.000 22.61982 ? 157 GLY A N   1 
ATOM   1157 C  CA  . GLY A 1 163 ? 38.40600 -22.38200 47.83200 1.000 22.01345 ? 157 GLY A CA  1 
ATOM   1158 C  C   . GLY A 1 163 ? 39.69700 -21.82500 47.28600 1.000 24.44259 ? 157 GLY A C   1 
ATOM   1159 O  O   . GLY A 1 163 ? 40.14400 -20.74400 47.67800 1.000 24.28018 ? 157 GLY A O   1 
ATOM   1160 N  N   . ILE A 1 164 ? 40.29700 -22.57500 46.36300 1.000 20.02881 ? 158 ILE A N   1 
ATOM   1161 C  CA  . ILE A 1 164 ? 41.52600 -22.19200 45.67700 1.000 22.51796 ? 158 ILE A CA  1 
ATOM   1162 C  C   . ILE A 1 164 ? 41.31500 -22.46600 44.19100 1.000 23.37756 ? 158 ILE A C   1 
ATOM   1163 O  O   . ILE A 1 164 ? 40.79300 -23.52900 43.82800 1.000 18.68456 ? 158 ILE A O   1 
ATOM   1164 C  CB  . ILE A 1 164 ? 42.74000 -22.98100 46.21900 1.000 20.04165 ? 158 ILE A CB  1 
ATOM   1165 C  CG1 . ILE A 1 164 ? 42.92000 -22.75100 47.73600 1.000 19.31429 ? 158 ILE A CG1 1 
ATOM   1166 C  CG2 . ILE A 1 164 ? 44.02100 -22.63100 45.48600 1.000 18.11374 ? 158 ILE A CG2 1 
ATOM   1167 C  CD1 . ILE A 1 164 ? 44.03600 -23.61900 48.35100 1.000 21.94601 ? 158 ILE A CD1 1 
ATOM   1168 N  N   . MET A 1 165 ? 41.68000 -21.50500 43.34200 1.000 18.67972 ? 159 MET A N   1 
ATOM   1169 C  CA  . MET A 1 165 ? 41.72700 -21.70400 41.88700 1.000 19.11618 ? 159 MET A CA  1 
ATOM   1170 C  C   . MET A 1 165 ? 43.13700 -22.11200 41.47800 1.000 20.34966 ? 159 MET A C   1 
ATOM   1171 O  O   . MET A 1 165 ? 44.08100 -21.35200 41.70100 1.000 21.37983 ? 159 MET A O   1 
ATOM   1172 C  CB  . MET A 1 165 ? 41.35500 -20.43000 41.11200 1.000 18.79897 ? 159 MET A CB  1 
ATOM   1173 C  CG  . MET A 1 165 ? 40.65800 -20.66600 39.75600 1.000 18.48072 ? 159 MET A CG  1 
ATOM   1174 S  SD  . MET A 1 165 ? 40.69600 -19.25500 38.61900 1.000 19.98087 ? 159 MET A SD  1 
ATOM   1175 C  CE  . MET A 1 165 ? 42.46800 -18.89000 38.49500 1.000 22.91006 ? 159 MET A CE  1 
ATOM   1176 N  N   . VAL A 1 166 ? 43.26500 -23.26700 40.82600 1.000 21.81948 ? 160 VAL A N   1 
ATOM   1177 C  CA  . VAL A 1 166 ? 44.50800 -23.69100 40.19000 1.000 22.35475 ? 160 VAL A CA  1 
ATOM   1178 C  C   . VAL A 1 166 ? 44.39300 -23.42000 38.68800 1.000 21.11281 ? 160 VAL A C   1 
ATOM   1179 O  O   . VAL A 1 166 ? 43.67800 -24.12500 37.96900 1.000 22.38524 ? 160 VAL A O   1 
ATOM   1180 C  CB  . VAL A 1 166 ? 44.79700 -25.17100 40.45800 1.000 21.39740 ? 160 VAL A CB  1 
ATOM   1181 C  CG1 . VAL A 1 166 ? 46.07500 -25.59100 39.73200 1.000 24.49922 ? 160 VAL A CG1 1 
ATOM   1182 C  CG2 . VAL A 1 166 ? 44.86200 -25.44200 41.97100 1.000 22.08338 ? 160 VAL A CG2 1 
ATOM   1183 N  N   . TYR A 1 167 ? 45.11600 -22.42000 38.20300 1.000 22.39024 ? 161 TYR A N   1 
ATOM   1184 C  CA  . TYR A 1 167 ? 45.14500 -22.15200 36.77200 1.000 25.85721 ? 161 TYR A CA  1 
ATOM   1185 C  C   . TYR A 1 167 ? 45.75400 -23.32800 36.02200 1.000 26.45712 ? 161 TYR A C   1 
ATOM   1186 O  O   . TYR A 1 167 ? 46.77800 -23.88100 36.42700 1.000 26.76923 ? 161 TYR A O   1 
ATOM   1187 C  CB  . TYR A 1 167 ? 45.95100 -20.88700 36.50200 1.000 24.78984 ? 161 TYR A CB  1 
ATOM   1188 C  CG  . TYR A 1 167 ? 46.04900 -20.48400 35.04300 1.000 29.43214 ? 161 TYR A CG  1 
ATOM   1189 C  CD1 . TYR A 1 167 ? 44.91100 -20.46700 34.21500 1.000 27.37009 ? 161 TYR A CD1 1 
ATOM   1190 C  CD2 . TYR A 1 167 ? 47.26400 -20.07200 34.50200 1.000 26.45541 ? 161 TYR A CD2 1 
ATOM   1191 C  CE1 . TYR A 1 167 ? 44.99600 -20.06000 32.88200 1.000 27.10378 ? 161 TYR A CE1 1 
ATOM   1192 C  CE2 . TYR A 1 167 ? 47.36300 -19.66500 33.17200 1.000 27.64450 ? 161 TYR A CE2 1 
ATOM   1193 C  CZ  . TYR A 1 167 ? 46.22500 -19.65600 32.37200 1.000 34.53956 ? 161 TYR A CZ  1 
ATOM   1194 O  OH  . TYR A 1 167 ? 46.32000 -19.24500 31.06300 1.000 33.85333 ? 161 TYR A OH  1 
ATOM   1195 N  N   . GLY A 1 168 ? 45.12200 -23.71000 34.90900 1.000 24.88971 ? 162 GLY A N   1 
ATOM   1196 C  CA  . GLY A 1 168 ? 45.64800 -24.81000 34.12000 1.000 27.63113 ? 162 GLY A CA  1 
ATOM   1197 C  C   . GLY A 1 168 ? 47.01700 -24.51900 33.52200 1.000 30.94184 ? 162 GLY A C   1 
ATOM   1198 O  O   . GLY A 1 168 ? 47.77700 -25.44300 33.21600 1.000 33.76750 ? 162 GLY A O   1 
ATOM   1199 N  N   . GLY A 1 169 ? 47.34900 -23.24900 33.34500 1.000 28.08303 ? 163 GLY A N   1 
ATOM   1200 C  CA  . GLY A 1 169 ? 48.64100 -22.87000 32.81700 1.000 32.50058 ? 163 GLY A CA  1 
ATOM   1201 C  C   . GLY A 1 169 ? 48.61100 -22.60700 31.31600 1.000 31.33138 ? 163 GLY A C   1 
ATOM   1202 O  O   . GLY A 1 169 ? 47.73500 -23.07700 30.57900 1.000 28.45795 ? 163 GLY A O   1 
ATOM   1203 N  N   . THR A 1 170 ? 49.61000 -21.85600 30.85800 1.000 29.66663 ? 164 THR A N   1 
ATOM   1204 C  CA  . THR A 1 170 ? 49.67600 -21.38800 29.47900 1.000 35.49468 ? 164 THR A CA  1 
ATOM   1205 C  C   . THR A 1 170 ? 50.38500 -22.39700 28.57400 1.000 35.17176 ? 164 THR A C   1 
ATOM   1206 O  O   . THR A 1 170 ? 51.28400 -23.12100 29.00800 1.000 36.30196 ? 164 THR A O   1 
ATOM   1207 C  CB  . THR A 1 170 ? 50.39200 -20.03600 29.42500 1.000 35.89082 ? 164 THR A CB  1 
ATOM   1208 O  OG1 . THR A 1 170 ? 50.33900 -19.52400 28.09600 1.000 52.35697 ? 164 THR A OG1 1 
ATOM   1209 C  CG2 . THR A 1 170 ? 51.87600 -20.18100 29.84300 1.000 37.37876 ? 164 THR A CG2 1 
ATOM   1210 N  N   . ILE A 1 171 ? 49.95600 -22.43900 27.30300 1.000 33.11783 ? 165 ILE A N   1 
ATOM   1211 C  CA  . ILE A 1 171 ? 50.54400 -23.32000 26.28700 1.000 37.60713 ? 165 ILE A CA  1 
ATOM   1212 C  C   . ILE A 1 171 ? 51.96900 -22.87600 25.93800 1.000 42.59394 ? 165 ILE A C   1 
ATOM   1213 O  O   . ILE A 1 171 ? 52.29800 -21.68300 25.95400 1.000 39.55737 ? 165 ILE A O   1 
ATOM   1214 C  CB  . ILE A 1 171 ? 49.65400 -23.32600 25.02400 1.000 44.88069 ? 165 ILE A CB  1 
ATOM   1215 C  CG1 . ILE A 1 171 ? 49.97800 -24.51100 24.09800 1.000 47.07329 ? 165 ILE A CG1 1 
ATOM   1216 C  CG2 . ILE A 1 171 ? 49.79000 -21.99900 24.23000 1.000 46.89423 ? 165 ILE A CG2 1 
ATOM   1217 C  CD1 . ILE A 1 171 ? 49.23100 -24.46900 22.72800 1.000 44.90368 ? 165 ILE A CD1 1 
ATOM   1218 N  N   . LYS A 1 172 ? 52.82800 -23.84900 25.57900 1.000 44.42329 ? 166 LYS A N   1 
ATOM   1219 C  CA  . LYS A 1 172 ? 54.16000 -23.45400 25.14200 1.000 51.88486 ? 166 LYS A CA  1 
ATOM   1220 C  C   . LYS A 1 172 ? 54.11100 -22.92100 23.70500 1.000 60.41594 ? 166 LYS A C   1 
ATOM   1221 O  O   . LYS A 1 172 ? 53.27900 -23.35500 22.89900 1.000 53.79942 ? 166 LYS A O   1 
ATOM   1222 C  CB  . LYS A 1 172 ? 55.13700 -24.63100 25.22300 1.000 56.13798 ? 166 LYS A CB  1 
ATOM   1223 C  CG  . LYS A 1 172 ? 55.18200 -25.49800 23.96600 1.000 60.53063 ? 166 LYS A CG  1 
ATOM   1224 C  CD  . LYS A 1 172 ? 55.65200 -26.91800 24.23900 1.000 62.89966 ? 166 LYS A CD  1 
ATOM   1225 C  CE  . LYS A 1 172 ? 54.52100 -27.78000 24.76800 1.000 62.56341 ? 166 LYS A CE  1 
ATOM   1226 N  NZ  . LYS A 1 172 ? 53.48000 -28.13800 23.75800 1.000 57.86441 ? 166 LYS A NZ  1 
ATOM   1227 N  N   . PRO A 1 173 ? 54.97100 -21.95600 23.36500 1.000 64.64837 ? 167 PRO A N   1 
ATOM   1228 C  CA  . PRO A 1 173 ? 55.03200 -21.49300 21.97000 1.000 62.21169 ? 167 PRO A CA  1 
ATOM   1229 C  C   . PRO A 1 173 ? 55.44700 -22.61900 21.03100 1.000 62.61783 ? 167 PRO A C   1 
ATOM   1230 O  O   . PRO A 1 173 ? 56.28300 -23.46100 21.36600 1.000 60.70102 ? 167 PRO A O   1 
ATOM   1231 C  CB  . PRO A 1 173 ? 56.07800 -20.36900 21.99500 1.000 65.93431 ? 167 PRO A CB  1 
ATOM   1232 C  CG  . PRO A 1 173 ? 56.55300 -20.24000 23.39600 1.000 65.79536 ? 167 PRO A CG  1 
ATOM   1233 C  CD  . PRO A 1 173 ? 55.76800 -21.13000 24.29300 1.000 62.44601 ? 167 PRO A CD  1 
ATOM   1234 N  N   . GLY A 1 174 ? 54.83300 -22.64200 19.85000 1.000 65.99134 ? 168 GLY A N   1 
ATOM   1235 C  CA  . GLY A 1 174 ? 55.25700 -23.57300 18.81500 1.000 65.85596 ? 168 GLY A CA  1 
ATOM   1236 C  C   . GLY A 1 174 ? 56.51800 -23.07500 18.12000 1.000 70.20534 ? 168 GLY A C   1 
ATOM   1237 O  O   . GLY A 1 174 ? 56.71500 -21.87500 17.92600 1.000 66.38090 ? 168 GLY A O   1 
ATOM   1238 N  N   . HIS A 1 175 ? 57.38200 -24.01900 17.74900 1.000 69.67700 ? 169 HIS A N   1 
ATOM   1239 C  CA  . HIS A 1 175 ? 58.64200 -23.69600 17.08500 1.000 74.16840 ? 169 HIS A CA  1 
ATOM   1240 C  C   . HIS A 1 175 ? 58.84100 -24.63400 15.90200 1.000 75.04268 ? 169 HIS A C   1 
ATOM   1241 O  O   . HIS A 1 175 ? 58.67400 -25.85100 16.03500 1.000 70.22557 ? 169 HIS A O   1 
ATOM   1242 C  CB  . HIS A 1 175 ? 59.83400 -23.80300 18.05100 1.000 72.94675 ? 169 HIS A CB  1 
ATOM   1243 C  CG  . HIS A 1 175 ? 59.76200 -22.86300 19.22100 1.000 83.06347 ? 169 HIS A CG  1 
ATOM   1244 N  ND1 . HIS A 1 175 ? 59.65000 -21.49500 19.07800 1.000 82.23772 ? 169 HIS A ND1 1 
ATOM   1245 C  CD2 . HIS A 1 175 ? 59.79800 -23.09700 20.55600 1.000 78.97459 ? 169 HIS A CD2 1 
ATOM   1246 C  CE1 . HIS A 1 175 ? 59.61200 -20.92900 20.27200 1.000 77.46499 ? 169 HIS A CE1 1 
ATOM   1247 N  NE2 . HIS A 1 175 ? 59.70000 -21.87900 21.18600 1.000 70.16902 ? 169 HIS A NE2 1 
ATOM   1248 N  N   . PHE A 1 176 ? 59.19600 -24.06500 14.75100 1.000 71.68740 ? 170 PHE A N   1 
ATOM   1249 C  CA  . PHE A 1 176 ? 59.48600 -24.85800 13.55800 1.000 70.96383 ? 170 PHE A CA  1 
ATOM   1250 C  C   . PHE A 1 176 ? 60.49600 -24.11600 12.69700 1.000 69.75289 ? 170 PHE A C   1 
ATOM   1251 O  O   . PHE A 1 176 ? 60.23800 -22.98000 12.28100 1.000 65.25805 ? 170 PHE A O   1 
ATOM   1252 C  CB  . PHE A 1 176 ? 58.21700 -25.14400 12.75300 1.000 73.05212 ? 170 PHE A CB  1 
ATOM   1253 C  CG  . PHE A 1 176 ? 58.43000 -26.09600 11.60300 1.000 75.44102 ? 170 PHE A CG  1 
ATOM   1254 C  CD1 . PHE A 1 176 ? 58.86500 -27.39400 11.83100 1.000 72.05363 ? 170 PHE A CD1 1 
ATOM   1255 C  CD2 . PHE A 1 176 ? 58.21600 -25.68400 10.29300 1.000 71.19016 ? 170 PHE A CD2 1 
ATOM   1256 C  CE1 . PHE A 1 176 ? 59.06400 -28.26900 10.77700 1.000 64.17967 ? 170 PHE A CE1 1 
ATOM   1257 C  CE2 . PHE A 1 176 ? 58.42000 -26.55300 9.23600  1.000 69.86740 ? 170 PHE A CE2 1 
ATOM   1258 C  CZ  . PHE A 1 176 ? 58.84300 -27.84700 9.48100  1.000 65.70919 ? 170 PHE A CZ  1 
ATOM   1259 N  N   . GLN A 1 177 ? 61.63500 -24.75900 12.43500 1.000 69.00768 ? 171 GLN A N   1 
ATOM   1260 C  CA  . GLN A 1 177 ? 62.63800 -24.25400 11.49800 1.000 63.70727 ? 171 GLN A CA  1 
ATOM   1261 C  C   . GLN A 1 177 ? 63.03100 -22.81300 11.82400 1.000 65.19849 ? 171 GLN A C   1 
ATOM   1262 O  O   . GLN A 1 177 ? 62.94900 -21.91200 10.98300 1.000 61.57431 ? 171 GLN A O   1 
ATOM   1263 C  CB  . GLN A 1 177 ? 62.13800 -24.38000 10.05900 1.000 59.56966 ? 171 GLN A CB  1 
ATOM   1264 C  CG  . GLN A 1 177 ? 62.07900 -25.81700 9.57100  1.000 57.93849 ? 171 GLN A CG  1 
ATOM   1265 C  CD  . GLN A 1 177 ? 63.45100 -26.47000 9.54600  1.000 56.50255 ? 171 GLN A CD  1 
ATOM   1266 O  OE1 . GLN A 1 177 ? 63.65700 -27.53700 10.12300 1.000 55.24039 ? 171 GLN A OE1 1 
ATOM   1267 N  NE2 . GLN A 1 177 ? 64.40300 -25.81700 8.88700  1.000 50.02857 ? 171 GLN A NE2 1 
ATOM   1268 N  N   . ASP A 1 178 ? 63.45200 -22.60500 13.07800 1.000 64.46689 ? 172 ASP A N   1 
ATOM   1269 C  CA  . ASP A 1 178 ? 63.93700 -21.30800 13.56400 1.000 70.46431 ? 172 ASP A CA  1 
ATOM   1270 C  C   . ASP A 1 178 ? 62.88100 -20.21100 13.40400 1.000 73.80124 ? 172 ASP A C   1 
ATOM   1271 O  O   . ASP A 1 178 ? 63.18600 -19.07100 13.03900 1.000 72.05482 ? 172 ASP A O   1 
ATOM   1272 C  CB  . ASP A 1 178 ? 65.24800 -20.90900 12.87400 1.000 69.10144 ? 172 ASP A CB  1 
ATOM   1273 C  CG  . ASP A 1 178 ? 66.46300 -21.65500 13.43000 1.000 65.82648 ? 172 ASP A CG  1 
ATOM   1274 O  OD1 . ASP A 1 178 ? 66.37000 -22.88700 13.65900 1.000 60.35443 ? 172 ASP A OD1 1 
ATOM   1275 O  OD2 . ASP A 1 178 ? 67.51000 -21.00000 13.63800 1.000 56.63165 ? 172 ASP A OD2 1 
ATOM   1276 N  N   . LYS A 1 179 ? 61.62500 -20.55700 13.68100 1.000 72.89789 ? 173 LYS A N   1 
ATOM   1277 C  CA  . LYS A 1 179 ? 60.53300 -19.59600 13.63400 1.000 75.57517 ? 173 LYS A CA  1 
ATOM   1278 C  C   . LYS A 1 179 ? 59.54000 -19.93600 14.73900 1.000 75.14783 ? 173 LYS A C   1 
ATOM   1279 O  O   . LYS A 1 179 ? 59.23800 -21.11100 14.97300 1.000 67.64763 ? 173 LYS A O   1 
ATOM   1280 C  CB  . LYS A 1 179 ? 59.84800 -19.59500 12.25400 1.000 75.55060 ? 173 LYS A CB  1 
ATOM   1281 C  CG  . LYS A 1 179 ? 59.47600 -18.20700 11.72500 1.000 75.42681 ? 173 LYS A CG  1 
ATOM   1282 C  CD  . LYS A 1 179 ? 58.73100 -18.29600 10.39500 1.000 75.63777 ? 173 LYS A CD  1 
ATOM   1283 C  CE  . LYS A 1 179 ? 58.71300 -16.96700 9.64000  1.000 78.81581 ? 173 LYS A CE  1 
ATOM   1284 N  NZ  . LYS A 1 179 ? 58.55800 -17.14800 8.16300  1.000 65.93792 ? 173 LYS A NZ  1 
ATOM   1285 N  N   . THR A 1 180 ? 59.05000 -18.90300 15.42300 1.000 76.98198 ? 174 THR A N   1 
ATOM   1286 C  CA  . THR A 1 180 ? 58.11400 -19.04900 16.53400 1.000 77.66435 ? 174 THR A CA  1 
ATOM   1287 C  C   . THR A 1 180 ? 56.68700 -18.79300 16.05700 1.000 76.49133 ? 174 THR A C   1 
ATOM   1288 O  O   . THR A 1 180 ? 56.40700 -17.75400 15.44700 1.000 76.49117 ? 174 THR A O   1 
ATOM   1289 C  CB  . THR A 1 180 ? 58.46800 -18.09000 17.67600 1.000 73.52388 ? 174 THR A CB  1 
ATOM   1290 O  OG1 . THR A 1 180 ? 59.72700 -18.47000 18.24800 1.000 71.96107 ? 174 THR A OG1 1 
ATOM   1291 C  CG2 . THR A 1 180 ? 57.39100 -18.10600 18.75900 1.000 69.83174 ? 174 THR A CG2 1 
ATOM   1292 N  N   . TYR A 1 181 ? 55.78900 -19.74200 16.34400 1.000 73.38455 ? 175 TYR A N   1 
ATOM   1293 C  CA  . TYR A 1 181 ? 54.38300 -19.66900 15.96400 1.000 72.05087 ? 175 TYR A CA  1 
ATOM   1294 C  C   . TYR A 1 181 ? 53.50200 -19.85600 17.19700 1.000 66.34444 ? 175 TYR A C   1 
ATOM   1295 O  O   . TYR A 1 181 ? 53.83300 -20.64500 18.08900 1.000 62.38090 ? 175 TYR A O   1 
ATOM   1296 C  CB  . TYR A 1 181 ? 54.02600 -20.75200 14.92300 1.000 72.11658 ? 175 TYR A CB  1 
ATOM   1297 C  CG  . TYR A 1 181 ? 54.80300 -20.72600 13.61200 1.000 76.23137 ? 175 TYR A CG  1 
ATOM   1298 C  CD1 . TYR A 1 181 ? 54.68000 -19.66300 12.71300 1.000 73.21141 ? 175 TYR A CD1 1 
ATOM   1299 C  CD2 . TYR A 1 181 ? 55.64100 -21.78700 13.26300 1.000 73.38076 ? 175 TYR A CD2 1 
ATOM   1300 C  CE1 . TYR A 1 181 ? 55.38500 -19.65600 11.50800 1.000 73.73005 ? 175 TYR A CE1 1 
ATOM   1301 C  CE2 . TYR A 1 181 ? 56.34500 -21.78700 12.06700 1.000 73.70355 ? 175 TYR A CE2 1 
ATOM   1302 C  CZ  . TYR A 1 181 ? 56.21500 -20.72200 11.19400 1.000 72.74133 ? 175 TYR A CZ  1 
ATOM   1303 O  OH  . TYR A 1 181 ? 56.91500 -20.73500 10.00800 1.000 72.46217 ? 175 TYR A OH  1 
ATOM   1304 N  N   . ASP A 1 182 ? 52.38000 -19.13200 17.24800 1.000 64.76238 ? 176 ASP A N   1 
ATOM   1305 C  CA  . ASP A 1 182 ? 51.34800 -19.35400 18.26800 1.000 60.74250 ? 176 ASP A CA  1 
ATOM   1306 C  C   . ASP A 1 182 ? 49.97600 -19.25600 17.59200 1.000 57.92716 ? 176 ASP A C   1 
ATOM   1307 O  O   . ASP A 1 182 ? 49.87600 -19.15500 16.36400 1.000 48.43976 ? 176 ASP A O   1 
ATOM   1308 C  CB  . ASP A 1 182 ? 51.50800 -18.38700 19.45700 1.000 62.43571 ? 176 ASP A CB  1 
ATOM   1309 C  CG  . ASP A 1 182 ? 51.53600 -16.91400 19.04800 1.000 65.08761 ? 176 ASP A CG  1 
ATOM   1310 O  OD1 . ASP A 1 182 ? 51.34700 -16.59800 17.85100 1.000 68.21740 ? 176 ASP A OD1 1 
ATOM   1311 O  OD2 . ASP A 1 182 ? 51.76300 -16.06400 19.94000 1.000 62.99174 ? 176 ASP A OD2 1 
ATOM   1312 N  N   . ILE A 1 183 ? 48.90600 -19.30000 18.40200 1.000 55.39790 ? 177 ILE A N   1 
ATOM   1313 C  CA  . ILE A 1 183 ? 47.54400 -19.21400 17.86300 1.000 53.03900 ? 177 ILE A CA  1 
ATOM   1314 C  C   . ILE A 1 183 ? 47.33400 -17.90100 17.11400 1.000 51.09372 ? 177 ILE A C   1 
ATOM   1315 O  O   . ILE A 1 183 ? 46.52900 -17.83500 16.17700 1.000 49.01728 ? 177 ILE A O   1 
ATOM   1316 C  CB  . ILE A 1 183 ? 46.49200 -19.40400 18.98500 1.000 51.15230 ? 177 ILE A CB  1 
ATOM   1317 C  CG1 . ILE A 1 183 ? 45.06300 -19.52800 18.40700 1.000 43.99996 ? 177 ILE A CG1 1 
ATOM   1318 C  CG2 . ILE A 1 183 ? 46.56400 -18.27100 20.01900 1.000 48.28707 ? 177 ILE A CG2 1 
ATOM   1319 C  CD1 . ILE A 1 183 ? 44.88100 -20.58600 17.28300 1.000 38.05086 ? 177 ILE A CD1 1 
ATOM   1320 N  N   . VAL A 1 184 ? 48.05400 -16.84300 17.49900 1.000 52.22704 ? 178 VAL A N   1 
ATOM   1321 C  CA  . VAL A 1 184 ? 48.00700 -15.59600 16.73600 1.000 57.20086 ? 178 VAL A CA  1 
ATOM   1322 C  C   . VAL A 1 184 ? 48.53200 -15.81600 15.31800 1.000 53.82294 ? 178 VAL A C   1 
ATOM   1323 O  O   . VAL A 1 184 ? 47.94500 -15.32900 14.34100 1.000 52.55483 ? 178 VAL A O   1 
ATOM   1324 C  CB  . VAL A 1 184 ? 48.78500 -14.48800 17.47500 1.000 61.14744 ? 178 VAL A CB  1 
ATOM   1325 C  CG1 . VAL A 1 184 ? 48.86700 -13.22500 16.62400 1.000 52.67287 ? 178 VAL A CG1 1 
ATOM   1326 C  CG2 . VAL A 1 184 ? 48.13700 -14.19000 18.82900 1.000 58.54668 ? 178 VAL A CG2 1 
ATOM   1327 N  N   . SER A 1 185 ? 49.63400 -16.56700 15.18000 1.000 49.95596 ? 179 SER A N   1 
ATOM   1328 C  CA  . SER A 1 185 ? 50.15400 -16.91800 13.85800 1.000 52.55418 ? 179 SER A CA  1 
ATOM   1329 C  C   . SER A 1 185 ? 49.08900 -17.60700 13.01400 1.000 54.71919 ? 179 SER A C   1 
ATOM   1330 O  O   . SER A 1 185 ? 48.87500 -17.25100 11.84800 1.000 50.69308 ? 179 SER A O   1 
ATOM   1331 C  CB  . SER A 1 185 ? 51.38300 -17.82200 13.99200 1.000 57.05445 ? 179 SER A CB  1 
ATOM   1332 O  OG  . SER A 1 185 ? 52.33900 -17.27800 14.88300 1.000 61.55204 ? 179 SER A OG  1 
ATOM   1333 N  N   . ALA A 1 186 ? 48.41400 -18.60400 13.59600 1.000 48.89380 ? 180 ALA A N   1 
ATOM   1334 C  CA  . ALA A 1 186 ? 47.37500 -19.33800 12.87900 1.000 50.49462 ? 180 ALA A CA  1 
ATOM   1335 C  C   . ALA A 1 186 ? 46.25200 -18.41500 12.41000 1.000 46.86177 ? 180 ALA A C   1 
ATOM   1336 O  O   . ALA A 1 186 ? 45.79900 -18.50900 11.26200 1.000 43.43589 ? 180 ALA A O   1 
ATOM   1337 C  CB  . ALA A 1 186 ? 46.82300 -20.44900 13.77100 1.000 37.34652 ? 180 ALA A CB  1 
ATOM   1338 N  N   . PHE A 1 187 ? 45.78300 -17.52200 13.28200 1.000 43.89676 ? 181 PHE A N   1 
ATOM   1339 C  CA  . PHE A 1 187 ? 44.71900 -16.60700 12.88000 1.000 48.78189 ? 181 PHE A CA  1 
ATOM   1340 C  C   . PHE A 1 187 ? 45.18400 -15.66700 11.77300 1.000 52.94639 ? 181 PHE A C   1 
ATOM   1341 O  O   . PHE A 1 187 ? 44.45600 -15.43700 10.79800 1.000 50.02570 ? 181 PHE A O   1 
ATOM   1342 C  CB  . PHE A 1 187 ? 44.23000 -15.81100 14.09000 1.000 50.40289 ? 181 PHE A CB  1 
ATOM   1343 C  CG  . PHE A 1 187 ? 43.14500 -16.50200 14.85600 1.000 51.19421 ? 181 PHE A CG  1 
ATOM   1344 C  CD1 . PHE A 1 187 ? 43.45000 -17.45300 15.81200 1.000 48.00897 ? 181 PHE A CD1 1 
ATOM   1345 C  CD2 . PHE A 1 187 ? 41.81700 -16.21800 14.60600 1.000 55.78905 ? 181 PHE A CD2 1 
ATOM   1346 C  CE1 . PHE A 1 187 ? 42.45300 -18.09000 16.51800 1.000 43.60294 ? 181 PHE A CE1 1 
ATOM   1347 C  CE2 . PHE A 1 187 ? 40.81300 -16.85600 15.30900 1.000 49.53641 ? 181 PHE A CE2 1 
ATOM   1348 C  CZ  . PHE A 1 187 ? 41.13700 -17.79000 16.26700 1.000 44.59768 ? 181 PHE A CZ  1 
ATOM   1349 N  N   . GLN A 1 188 ? 46.40200 -15.12900 11.90100 1.000 54.15041 ? 182 GLN A N   1 
ATOM   1350 C  CA  . GLN A 1 188 ? 46.95000 -14.20800 10.90900 1.000 56.60731 ? 182 GLN A CA  1 
ATOM   1351 C  C   . GLN A 1 188 ? 47.18300 -14.86100 9.55800  1.000 56.24595 ? 182 GLN A C   1 
ATOM   1352 O  O   . GLN A 1 188 ? 47.29000 -14.14700 8.55300  1.000 55.43499 ? 182 GLN A O   1 
ATOM   1353 C  CB  . GLN A 1 188 ? 48.28200 -13.63800 11.39700 1.000 56.96221 ? 182 GLN A CB  1 
ATOM   1354 C  CG  . GLN A 1 188 ? 48.19000 -12.75100 12.61100 1.000 62.06070 ? 182 GLN A CG  1 
ATOM   1355 C  CD  . GLN A 1 188 ? 49.54600 -12.19600 12.99100 1.000 64.81697 ? 182 GLN A CD  1 
ATOM   1356 O  OE1 . GLN A 1 188 ? 49.65300 -11.28400 13.80600 1.000 61.46105 ? 182 GLN A OE1 1 
ATOM   1357 N  NE2 . GLN A 1 188 ? 50.59400 -12.75000 12.39500 1.000 66.62528 ? 182 GLN A NE2 1 
ATOM   1358 N  N   . SER A 1 189 ? 47.27800 -16.19300 9.51800  1.000 49.46156 ? 183 SER A N   1 
ATOM   1359 C  CA  . SER A 1 189 ? 47.78600 -16.87400 8.33200  1.000 55.45470 ? 183 SER A CA  1 
ATOM   1360 C  C   . SER A 1 189 ? 46.90100 -16.63100 7.10700  1.000 59.74943 ? 183 SER A C   1 
ATOM   1361 O  O   . SER A 1 189 ? 47.41100 -16.47400 5.99000  1.000 62.50179 ? 183 SER A O   1 
ATOM   1362 C  CB  . SER A 1 189 ? 47.93800 -18.36900 8.62700  1.000 56.21224 ? 183 SER A CB  1 
ATOM   1363 O  OG  . SER A 1 189 ? 46.68300 -19.02600 8.65600  1.000 56.33103 ? 183 SER A OG  1 
ATOM   1364 N  N   . TYR A 1 190 ? 45.57500 -16.57900 7.29500  1.000 54.26956 ? 184 TYR A N   1 
ATOM   1365 C  CA  . TYR A 1 190 ? 44.67500 -16.41700 6.15100  1.000 54.52352 ? 184 TYR A CA  1 
ATOM   1366 C  C   . TYR A 1 190 ? 44.83500 -15.04600 5.49700  1.000 60.21205 ? 184 TYR A C   1 
ATOM   1367 O  O   . TYR A 1 190 ? 44.88100 -14.94300 4.26400  1.000 57.42708 ? 184 TYR A O   1 
ATOM   1368 C  CB  . TYR A 1 190 ? 43.22300 -16.63900 6.57900  1.000 49.26007 ? 184 TYR A CB  1 
ATOM   1369 C  CG  . TYR A 1 190 ? 42.24500 -16.59100 5.42300  1.000 51.79557 ? 184 TYR A CG  1 
ATOM   1370 C  CD1 . TYR A 1 190 ? 42.35100 -17.47700 4.35500  1.000 49.69185 ? 184 TYR A CD1 1 
ATOM   1371 C  CD2 . TYR A 1 190 ? 41.22200 -15.64900 5.39400  1.000 57.38556 ? 184 TYR A CD2 1 
ATOM   1372 C  CE1 . TYR A 1 190 ? 41.46200 -17.42800 3.29500  1.000 53.20671 ? 184 TYR A CE1 1 
ATOM   1373 C  CE2 . TYR A 1 190 ? 40.32100 -15.59600 4.33100  1.000 55.93819 ? 184 TYR A CE2 1 
ATOM   1374 C  CZ  . TYR A 1 190 ? 40.44700 -16.48800 3.28900  1.000 52.45986 ? 184 TYR A CZ  1 
ATOM   1375 O  OH  . TYR A 1 190 ? 39.55300 -16.42900 2.23700  1.000 62.45982 ? 184 TYR A OH  1 
ATOM   1376 N  N   . GLY A 1 191 ? 44.91000 -13.98200 6.30400  1.000 59.32962 ? 185 GLY A N   1 
ATOM   1377 C  CA  . GLY A 1 191 ? 45.13000 -12.65700 5.74700  1.000 62.99420 ? 185 GLY A CA  1 
ATOM   1378 C  C   . GLY A 1 191 ? 46.43400 -12.55500 4.97700  1.000 68.41707 ? 185 GLY A C   1 
ATOM   1379 O  O   . GLY A 1 191 ? 46.49500 -11.91600 3.92200  1.000 67.15092 ? 185 GLY A O   1 
ATOM   1380 N  N   . GLU A 1 192 ? 47.49200 -13.19400 5.49000  1.000 63.37809 ? 186 GLU A N   1 
ATOM   1381 C  CA  . GLU A 1 192 ? 48.77100 -13.22800 4.78600  1.000 69.91089 ? 186 GLU A CA  1 
ATOM   1382 C  C   . GLU A 1 192 ? 48.71000 -14.06500 3.51300  1.000 69.17590 ? 186 GLU A C   1 
ATOM   1383 O  O   . GLU A 1 192 ? 49.54900 -13.88100 2.62400  1.000 70.62391 ? 186 GLU A O   1 
ATOM   1384 C  CB  . GLU A 1 192 ? 49.86300 -13.76200 5.71400  1.000 61.61060 ? 186 GLU A CB  1 
ATOM   1385 C  CG  . GLU A 1 192 ? 50.17900 -12.83100 6.86900  1.000 64.89449 ? 186 GLU A CG  1 
ATOM   1386 C  CD  . GLU A 1 192 ? 50.79500 -13.56000 8.04300  1.000 70.25935 ? 186 GLU A CD  1 
ATOM   1387 O  OE1 . GLU A 1 192 ? 50.96900 -14.79100 7.93800  1.000 72.01815 ? 186 GLU A OE1 1 
ATOM   1388 O  OE2 . GLU A 1 192 ? 51.09500 -12.91100 9.07100  1.000 65.46172 ? 186 GLU A OE2 1 
ATOM   1389 N  N   . PHE A 1 193 ? 47.74500 -14.98000 3.40900  1.000 68.36923 ? 187 PHE A N   1 
ATOM   1390 C  CA  . PHE A 1 193 ? 47.55200 -15.73800 2.17800  1.000 70.01738 ? 187 PHE A CA  1 
ATOM   1391 C  C   . PHE A 1 193 ? 46.80100 -14.91400 1.13800  1.000 69.52377 ? 187 PHE A C   1 
ATOM   1392 O  O   . PHE A 1 193 ? 47.18400 -14.88700 -0.03800 1.000 66.81736 ? 187 PHE A O   1 
ATOM   1393 C  CB  . PHE A 1 193 ? 46.80600 -17.04100 2.47700  1.000 64.87453 ? 187 PHE A CB  1 
ATOM   1394 C  CG  . PHE A 1 193 ? 46.38200 -17.79700 1.25000  1.000 69.19814 ? 187 PHE A CG  1 
ATOM   1395 C  CD1 . PHE A 1 193 ? 47.32500 -18.29500 0.36100  1.000 68.35875 ? 187 PHE A CD1 1 
ATOM   1396 C  CD2 . PHE A 1 193 ? 45.03600 -18.00400 0.98000  1.000 67.45437 ? 187 PHE A CD2 1 
ATOM   1397 C  CE1 . PHE A 1 193 ? 46.93300 -18.99100 -0.77000 1.000 66.20240 ? 187 PHE A CE1 1 
ATOM   1398 C  CE2 . PHE A 1 193 ? 44.63900 -18.69900 -0.14800 1.000 65.47544 ? 187 PHE A CE2 1 
ATOM   1399 C  CZ  . PHE A 1 193 ? 45.58800 -19.19100 -1.02400 1.000 66.70029 ? 187 PHE A CZ  1 
ATOM   1400 N  N   . VAL A 1 194 ? 45.73100 -14.23000 1.55700  1.000 67.48996 ? 188 VAL A N   1 
ATOM   1401 C  CA  . VAL A 1 194 ? 44.95300 -13.41800 0.62600  1.000 71.71791 ? 188 VAL A CA  1 
ATOM   1402 C  C   . VAL A 1 194 ? 45.76000 -12.20900 0.16300  1.000 73.65801 ? 188 VAL A C   1 
ATOM   1403 O  O   . VAL A 1 194 ? 45.68700 -11.81100 -1.00700 1.000 71.10074 ? 188 VAL A O   1 
ATOM   1404 C  CB  . VAL A 1 194 ? 43.61900 -13.00000 1.26900  1.000 67.12422 ? 188 VAL A CB  1 
ATOM   1405 C  CG1 . VAL A 1 194 ? 42.77900 -12.19900 0.28400  1.000 71.04975 ? 188 VAL A CG1 1 
ATOM   1406 C  CG2 . VAL A 1 194 ? 42.85700 -14.22600 1.75600  1.000 65.29829 ? 188 VAL A CG2 1 
ATOM   1407 N  N   . SER A 1 195 ? 46.54700 -11.61000 1.06800  1.000 70.68008 ? 189 SER A N   1 
ATOM   1408 C  CA  . SER A 1 195 ? 47.38800 -10.47100 0.70700  1.000 71.12445 ? 189 SER A CA  1 
ATOM   1409 C  C   . SER A 1 195 ? 48.52100 -10.85800 -0.23800 1.000 74.83496 ? 189 SER A C   1 
ATOM   1410 O  O   . SER A 1 195 ? 49.05500 -9.98800  -0.93700 1.000 76.85061 ? 189 SER A O   1 
ATOM   1411 C  CB  . SER A 1 195 ? 47.97100 -9.81600  1.96500  1.000 69.21428 ? 189 SER A CB  1 
ATOM   1412 O  OG  . SER A 1 195 ? 49.11900 -10.50700 2.43500  1.000 66.87278 ? 189 SER A OG  1 
ATOM   1413 N  N   . GLY A 1 196 ? 48.89500 -12.13700 -0.28100 1.000 71.04977 ? 190 GLY A N   1 
ATOM   1414 C  CA  . GLY A 1 196 ? 50.00300 -12.58900 -1.09400 1.000 74.10924 ? 190 GLY A CA  1 
ATOM   1415 C  C   . GLY A 1 196 ? 51.33400 -12.67500 -0.37600 1.000 78.10071 ? 190 GLY A C   1 
ATOM   1416 O  O   . GLY A 1 196 ? 52.32000 -13.10600 -0.99200 1.000 75.65406 ? 190 GLY A O   1 
ATOM   1417 N  N   . SER A 1 197 ? 51.39100 -12.28400 0.90500  1.000 73.96512 ? 191 SER A N   1 
ATOM   1418 C  CA  . SER A 1 197 ? 52.64700 -12.30900 1.65400  1.000 74.51093 ? 191 SER A CA  1 
ATOM   1419 C  C   . SER A 1 197 ? 53.22000 -13.72000 1.74000  1.000 76.39622 ? 191 SER A C   1 
ATOM   1420 O  O   . SER A 1 197 ? 54.43100 -13.92000 1.59400  1.000 72.61916 ? 191 SER A O   1 
ATOM   1421 C  CB  . SER A 1 197 ? 52.42800 -11.74500 3.06100  1.000 72.83224 ? 191 SER A CB  1 
ATOM   1422 O  OG  . SER A 1 197 ? 51.90800 -10.43000 3.01500  1.000 75.06901 ? 191 SER A OG  1 
ATOM   1423 N  N   . ILE A 1 198 ? 52.36600 -14.71000 1.99300  1.000 74.41302 ? 192 ILE A N   1 
ATOM   1424 C  CA  . ILE A 1 198 ? 52.78500 -16.09800 2.10300  1.000 72.78830 ? 192 ILE A CA  1 
ATOM   1425 C  C   . ILE A 1 198 ? 51.95300 -16.93800 1.14200  1.000 73.32634 ? 192 ILE A C   1 
ATOM   1426 O  O   . ILE A 1 198 ? 50.86800 -16.54300 0.70500  1.000 73.33140 ? 192 ILE A O   1 
ATOM   1427 C  CB  . ILE A 1 198 ? 52.65900 -16.63500 3.55000  1.000 72.11342 ? 192 ILE A CB  1 
ATOM   1428 C  CG1 . ILE A 1 198 ? 51.18200 -16.78400 3.94400  1.000 74.31662 ? 192 ILE A CG1 1 
ATOM   1429 C  CG2 . ILE A 1 198 ? 53.40800 -15.73700 4.52600  1.000 64.92646 ? 192 ILE A CG2 1 
ATOM   1430 C  CD1 . ILE A 1 198 ? 50.95700 -17.39100 5.32600  1.000 71.84316 ? 192 ILE A CD1 1 
ATOM   1431 N  N   . SER A 1 199 ? 52.48400 -18.11000 0.81000  1.000 72.13332 ? 193 SER A N   1 
ATOM   1432 C  CA  . SER A 1 199 ? 51.80000 -19.04400 -0.06900 1.000 72.78978 ? 193 SER A CA  1 
ATOM   1433 C  C   . SER A 1 199 ? 50.82300 -19.90400 0.72300  1.000 72.26617 ? 193 SER A C   1 
ATOM   1434 O  O   . SER A 1 199 ? 50.76300 -19.85600 1.95400  1.000 68.08074 ? 193 SER A O   1 
ATOM   1435 C  CB  . SER A 1 199 ? 52.80900 -19.93400 -0.79200 1.000 70.38981 ? 193 SER A CB  1 
ATOM   1436 O  OG  . SER A 1 199 ? 53.47400 -20.78700 0.12400  1.000 69.83859 ? 193 SER A OG  1 
ATOM   1437 N  N   . ASP A 1 200 ? 50.05100 -20.71200 -0.00600 1.000 71.65627 ? 194 ASP A N   1 
ATOM   1438 C  CA  . ASP A 1 200 ? 49.21600 -21.70800 0.65500  1.000 72.24774 ? 194 ASP A CA  1 
ATOM   1439 C  C   . ASP A 1 200 ? 50.05800 -22.72700 1.41500  1.000 73.69317 ? 194 ASP A C   1 
ATOM   1440 O  O   . ASP A 1 200 ? 49.64000 -23.21600 2.47300  1.000 69.89299 ? 194 ASP A O   1 
ATOM   1441 C  CB  . ASP A 1 200 ? 48.32500 -22.40900 -0.36900 1.000 73.06499 ? 194 ASP A CB  1 
ATOM   1442 C  CG  . ASP A 1 200 ? 47.12600 -23.06700 0.27100  1.000 68.45970 ? 194 ASP A CG  1 
ATOM   1443 O  OD1 . ASP A 1 200 ? 46.38600 -22.36400 0.99400  1.000 64.86917 ? 194 ASP A OD1 1 
ATOM   1444 O  OD2 . ASP A 1 200 ? 46.92300 -24.28000 0.05100  1.000 71.23234 ? 194 ASP A OD2 1 
ATOM   1445 N  N   . GLU A 1 201 ? 51.24800 -23.04600 0.89700  1.000 71.68075 ? 195 GLU A N   1 
ATOM   1446 C  CA  . GLU A 1 201 ? 52.11800 -24.02300 1.54700  1.000 71.35911 ? 195 GLU A CA  1 
ATOM   1447 C  C   . GLU A 1 201 ? 52.67100 -23.48200 2.86200  1.000 69.62778 ? 195 GLU A C   1 
ATOM   1448 O  O   . GLU A 1 201 ? 52.71600 -24.20200 3.86800  1.000 61.98842 ? 195 GLU A O   1 
ATOM   1449 C  CB  . GLU A 1 201 ? 53.25600 -24.41200 0.59900  1.000 76.98168 ? 195 GLU A CB  1 
ATOM   1450 C  CG  . GLU A 1 201 ? 52.85100 -25.35300 -0.54300 1.000 84.55792 ? 195 GLU A CG  1 
ATOM   1451 C  CD  . GLU A 1 201 ? 51.78700 -24.76600 -1.47300 1.000 84.08333 ? 195 GLU A CD  1 
ATOM   1452 O  OE1 . GLU A 1 201 ? 51.96500 -23.62700 -1.97800 1.000 72.68713 ? 195 GLU A OE1 1 
ATOM   1453 O  OE2 . GLU A 1 201 ? 50.76800 -25.45900 -1.69900 1.000 84.54167 ? 195 GLU A OE2 1 
ATOM   1454 N  N   . GLN A 1 202 ? 53.09600 -22.21300 2.86900  1.000 71.25376 ? 196 GLN A N   1 
ATOM   1455 C  CA  . GLN A 1 202 ? 53.54000 -21.57600 4.10700  1.000 70.86396 ? 196 GLN A CA  1 
ATOM   1456 C  C   . GLN A 1 202 ? 52.38500 -21.40300 5.08700  1.000 69.30962 ? 196 GLN A C   1 
ATOM   1457 O  O   . GLN A 1 202 ? 52.57600 -21.51800 6.30500  1.000 64.11369 ? 196 GLN A O   1 
ATOM   1458 C  CB  . GLN A 1 202 ? 54.17500 -20.22000 3.80400  1.000 68.70028 ? 196 GLN A CB  1 
ATOM   1459 C  CG  . GLN A 1 202 ? 55.63100 -20.29000 3.38900  1.000 76.00453 ? 196 GLN A CG  1 
ATOM   1460 C  CD  . GLN A 1 202 ? 56.14400 -18.95400 2.89200  1.000 75.94884 ? 196 GLN A CD  1 
ATOM   1461 O  OE1 . GLN A 1 202 ? 55.64800 -18.42100 1.90000  1.000 72.91647 ? 196 GLN A OE1 1 
ATOM   1462 N  NE2 . GLN A 1 202 ? 57.14400 -18.40700 3.57700  1.000 75.14202 ? 196 GLN A NE2 1 
ATOM   1463 N  N   . ARG A 1 203 ? 51.18700 -21.10300 4.56900  1.000 67.60721 ? 197 ARG A N   1 
ATOM   1464 C  CA  . ARG A 1 203 ? 49.99600 -21.00100 5.41000  1.000 65.27236 ? 197 ARG A CA  1 
ATOM   1465 C  C   . ARG A 1 203 ? 49.73600 -22.30500 6.15600  1.000 63.62055 ? 197 ARG A C   1 
ATOM   1466 O  O   . ARG A 1 203 ? 49.50200 -22.30400 7.37200  1.000 59.26424 ? 197 ARG A O   1 
ATOM   1467 C  CB  . ARG A 1 203 ? 48.78500 -20.61900 4.55300  1.000 60.78550 ? 197 ARG A CB  1 
ATOM   1468 C  CG  . ARG A 1 203 ? 47.56800 -20.15400 5.34100  1.000 59.81921 ? 197 ARG A CG  1 
ATOM   1469 C  CD  . ARG A 1 203 ? 46.31900 -20.12100 4.46400  1.000 57.00781 ? 197 ARG A CD  1 
ATOM   1470 N  NE  . ARG A 1 203 ? 46.10300 -21.37600 3.75000  1.000 60.03842 ? 197 ARG A NE  1 
ATOM   1471 C  CZ  . ARG A 1 203 ? 45.37800 -22.39200 4.20400  1.000 60.94137 ? 197 ARG A CZ  1 
ATOM   1472 N  NH1 . ARG A 1 203 ? 44.77500 -22.34500 5.38500  1.000 51.45299 ? 197 ARG A NH1 1 
ATOM   1473 N  NH2 . ARG A 1 203 ? 45.25200 -23.48500 3.45300  1.000 62.25356 ? 197 ARG A NH2 1 
ATOM   1474 N  N   . LYS A 1 204 ? 49.78600 -23.43300 5.44300  1.000 60.35770 ? 198 LYS A N   1 
ATOM   1475 C  CA  . LYS A 1 204 ? 49.52000 -24.72100 6.07700  1.000 64.12054 ? 198 LYS A CA  1 
ATOM   1476 C  C   . LYS A 1 204 ? 50.59100 -25.08600 7.10100  1.000 64.30731 ? 198 LYS A C   1 
ATOM   1477 O  O   . LYS A 1 204 ? 50.28200 -25.73900 8.10500  1.000 59.18082 ? 198 LYS A O   1 
ATOM   1478 C  CB  . LYS A 1 204 ? 49.39600 -25.81100 5.01100  1.000 64.23450 ? 198 LYS A CB  1 
ATOM   1479 C  CG  . LYS A 1 204 ? 47.98300 -25.94900 4.43200  1.000 67.94284 ? 198 LYS A CG  1 
ATOM   1480 C  CD  . LYS A 1 204 ? 48.00900 -26.25000 2.94100  1.000 67.60156 ? 198 LYS A CD  1 
ATOM   1481 C  CE  . LYS A 1 204 ? 47.58200 -27.68500 2.66300  1.000 59.24001 ? 198 LYS A CE  1 
ATOM   1482 N  NZ  . LYS A 1 204 ? 48.09700 -28.16200 1.34100  1.000 69.27947 ? 198 LYS A NZ  1 
ATOM   1483 N  N   . THR A 1 205 ? 51.84500 -24.67300 6.87300  1.000 63.21086 ? 199 THR A N   1 
ATOM   1484 C  CA  . THR A 1 205 ? 52.91000 -24.95100 7.83600  1.000 64.84439 ? 199 THR A CA  1 
ATOM   1485 C  C   . THR A 1 205 ? 52.63600 -24.26900 9.17100  1.000 61.55886 ? 199 THR A C   1 
ATOM   1486 O  O   . THR A 1 205 ? 52.86100 -24.85400 10.23800 1.000 59.85488 ? 199 THR A O   1 
ATOM   1487 C  CB  . THR A 1 205 ? 54.26000 -24.49100 7.28200  1.000 59.71305 ? 199 THR A CB  1 
ATOM   1488 O  OG1 . THR A 1 205 ? 54.36500 -24.85500 5.90300  1.000 61.24197 ? 199 THR A OG1 1 
ATOM   1489 C  CG2 . THR A 1 205 ? 55.39700 -25.13100 8.05700  1.000 57.46229 ? 199 THR A CG2 1 
ATOM   1490 N  N   . VAL A 1 206 ? 52.17100 -23.02100 9.12700  1.000 58.96136 ? 200 VAL A N   1 
ATOM   1491 C  CA  . VAL A 1 206 ? 51.83400 -22.29800 10.34700 1.000 61.18601 ? 200 VAL A CA  1 
ATOM   1492 C  C   . VAL A 1 206 ? 50.74200 -23.03100 11.12000 1.000 61.08086 ? 200 VAL A C   1 
ATOM   1493 O  O   . VAL A 1 206 ? 50.79100 -23.13100 12.35300 1.000 60.77942 ? 200 VAL A O   1 
ATOM   1494 C  CB  . VAL A 1 206 ? 51.41700 -20.86000 9.99600  1.000 62.02770 ? 200 VAL A CB  1 
ATOM   1495 C  CG1 . VAL A 1 206 ? 50.88600 -20.13400 11.22900 1.000 56.10957 ? 200 VAL A CG1 1 
ATOM   1496 C  CG2 . VAL A 1 206 ? 52.58900 -20.11600 9.36600  1.000 62.30781 ? 200 VAL A CG2 1 
ATOM   1497 N  N   . LEU A 1 207 ? 49.75000 -23.57100 10.40700 1.000 56.44758 ? 201 LEU A N   1 
ATOM   1498 C  CA  . LEU A 1 207 ? 48.62700 -24.23800 11.06300 1.000 56.95616 ? 201 LEU A CA  1 
ATOM   1499 C  C   . LEU A 1 207 ? 49.05300 -25.51900 11.77800 1.000 56.16025 ? 201 LEU A C   1 
ATOM   1500 O  O   . LEU A 1 207 ? 48.45600 -25.88200 12.80000 1.000 49.46493 ? 201 LEU A O   1 
ATOM   1501 C  CB  . LEU A 1 207 ? 47.52900 -24.54000 10.03900 1.000 51.38629 ? 201 LEU A CB  1 
ATOM   1502 C  CG  . LEU A 1 207 ? 46.79600 -23.34400 9.41600  1.000 53.34813 ? 201 LEU A CG  1 
ATOM   1503 C  CD1 . LEU A 1 207 ? 45.45700 -23.79400 8.82600  1.000 47.68747 ? 201 LEU A CD1 1 
ATOM   1504 C  CD2 . LEU A 1 207 ? 46.59200 -22.22600 10.43500 1.000 47.93082 ? 201 LEU A CD2 1 
ATOM   1505 N  N   . HIS A 1 208 ? 50.07600 -26.21200 11.27100 1.000 54.12281 ? 202 HIS A N   1 
ATOM   1506 C  CA  . HIS A 1 208 ? 50.50700 -27.47900 11.85500 1.000 60.31401 ? 202 HIS A CA  1 
ATOM   1507 C  C   . HIS A 1 208 ? 51.48500 -27.31900 13.01400 1.000 64.28373 ? 202 HIS A C   1 
ATOM   1508 O  O   . HIS A 1 208 ? 51.75000 -28.30200 13.71600 1.000 58.03359 ? 202 HIS A O   1 
ATOM   1509 C  CB  . HIS A 1 208 ? 51.15000 -28.36400 10.78500 1.000 58.93985 ? 202 HIS A CB  1 
ATOM   1510 C  CG  . HIS A 1 208 ? 50.16200 -29.05500 9.89600  1.000 59.64041 ? 202 HIS A CG  1 
ATOM   1511 N  ND1 . HIS A 1 208 ? 49.40800 -28.38300 8.95700  1.000 64.00602 ? 202 HIS A ND1 1 
ATOM   1512 C  CD2 . HIS A 1 208 ? 49.81800 -30.36100 9.78900  1.000 58.00270 ? 202 HIS A CD2 1 
ATOM   1513 C  CE1 . HIS A 1 208 ? 48.64000 -29.24400 8.31300  1.000 56.64298 ? 202 HIS A CE1 1 
ATOM   1514 N  NE2 . HIS A 1 208 ? 48.87000 -30.45100 8.79800  1.000 52.93843 ? 202 HIS A NE2 1 
ATOM   1515 N  N   . HIS A 1 209 ? 52.02400 -26.11100 13.23800 1.000 61.63312 ? 203 HIS A N   1 
ATOM   1516 C  CA  . HIS A 1 209 ? 53.04700 -25.88400 14.25500 1.000 60.13144 ? 203 HIS A CA  1 
ATOM   1517 C  C   . HIS A 1 209 ? 52.69800 -24.71500 15.17100 1.000 62.28596 ? 203 HIS A C   1 
ATOM   1518 O  O   . HIS A 1 209 ? 53.58200 -24.18900 15.86200 1.000 63.63080 ? 203 HIS A O   1 
ATOM   1519 C  CB  . HIS A 1 209 ? 54.41400 -25.64000 13.60300 1.000 64.32467 ? 203 HIS A CB  1 
ATOM   1520 C  CG  . HIS A 1 209 ? 54.91600 -26.79800 12.79800 1.000 69.63382 ? 203 HIS A CG  1 
ATOM   1521 N  ND1 . HIS A 1 209 ? 54.80900 -26.85100 11.42400 1.000 70.82528 ? 203 HIS A ND1 1 
ATOM   1522 C  CD2 . HIS A 1 209 ? 55.53100 -27.94500 13.17200 1.000 67.67065 ? 203 HIS A CD2 1 
ATOM   1523 C  CE1 . HIS A 1 209 ? 55.33100 -27.98400 10.98700 1.000 70.51371 ? 203 HIS A CE1 1 
ATOM   1524 N  NE2 . HIS A 1 209 ? 55.77600 -28.66500 12.02800 1.000 68.27446 ? 203 HIS A NE2 1 
ATOM   1525 N  N   . SER A 1 210 ? 51.43100 -24.29500 15.19200 1.000 57.72215 ? 204 SER A N   1 
ATOM   1526 C  CA  . SER A 1 210 ? 51.02000 -23.15100 15.99900 1.000 57.23144 ? 204 SER A CA  1 
ATOM   1527 C  C   . SER A 1 210 ? 50.70100 -23.52900 17.44400 1.000 57.18861 ? 204 SER A C   1 
ATOM   1528 O  O   . SER A 1 210 ? 50.99200 -22.75100 18.36200 1.000 56.09588 ? 204 SER A O   1 
ATOM   1529 C  CB  . SER A 1 210 ? 49.80300 -22.47300 15.36100 1.000 56.67683 ? 204 SER A CB  1 
ATOM   1530 O  OG  . SER A 1 210 ? 50.18800 -21.50800 14.39200 1.000 57.78002 ? 204 SER A OG  1 
ATOM   1531 N  N   . CYS A 1 211 ? 50.12300 -24.70700 17.66900 1.000 50.07173 ? 205 CYS A N   1 
ATOM   1532 C  CA  . CYS A 1 211 ? 49.66500 -25.12800 18.99200 1.000 51.60415 ? 205 CYS A CA  1 
ATOM   1533 C  C   . CYS A 1 211 ? 50.23600 -26.51000 19.28500 1.000 52.67321 ? 205 CYS A C   1 
ATOM   1534 O  O   . CYS A 1 211 ? 49.61400 -27.53000 18.96000 1.000 45.71890 ? 205 CYS A O   1 
ATOM   1535 C  CB  . CYS A 1 211 ? 48.13700 -25.11800 19.05900 1.000 44.77393 ? 205 CYS A CB  1 
ATOM   1536 S  SG  . CYS A 1 211 ? 47.40400 -23.53900 18.50600 1.000 50.36738 ? 205 CYS A SG  1 
ATOM   1537 N  N   . PRO A 1 212 ? 51.41900 -26.58600 19.90800 1.000 58.40135 ? 206 PRO A N   1 
ATOM   1538 C  CA  . PRO A 1 212 ? 52.10300 -27.88300 20.05500 1.000 55.12832 ? 206 PRO A CA  1 
ATOM   1539 C  C   . PRO A 1 212 ? 51.60600 -28.75700 21.20000 1.000 59.13349 ? 206 PRO A C   1 
ATOM   1540 O  O   . PRO A 1 212 ? 51.95800 -29.94700 21.23800 1.000 62.25167 ? 206 PRO A O   1 
ATOM   1541 C  CB  . PRO A 1 212 ? 53.56400 -27.47100 20.28100 1.000 56.92235 ? 206 PRO A CB  1 
ATOM   1542 C  CG  . PRO A 1 212 ? 53.44800 -26.18400 21.02800 1.000 57.68681 ? 206 PRO A CG  1 
ATOM   1543 C  CD  . PRO A 1 212 ? 52.22800 -25.47700 20.45000 1.000 59.73197 ? 206 PRO A CD  1 
ATOM   1544 N  N   . GLY A 1 213 ? 50.81800 -28.22800 22.12500 1.000 55.22155 ? 207 GLY A N   1 
ATOM   1545 C  CA  . GLY A 1 213 ? 50.38800 -29.02300 23.25600 1.000 49.39251 ? 207 GLY A CA  1 
ATOM   1546 C  C   . GLY A 1 213 ? 49.28200 -28.34200 24.02700 1.000 47.16046 ? 207 GLY A C   1 
ATOM   1547 O  O   . GLY A 1 213 ? 48.56800 -27.49100 23.49300 1.000 46.02763 ? 207 GLY A O   1 
ATOM   1548 N  N   . ALA A 1 214 ? 49.15500 -28.72800 25.29600 1.000 43.62769 ? 208 ALA A N   1 
ATOM   1549 C  CA  . ALA A 1 214 ? 48.07700 -28.26300 26.16000 1.000 45.51209 ? 208 ALA A CA  1 
ATOM   1550 C  C   . ALA A 1 214 ? 48.41700 -26.91400 26.78200 1.000 41.24533 ? 208 ALA A C   1 
ATOM   1551 O  O   . ALA A 1 214 ? 49.58400 -26.59800 27.02700 1.000 46.20606 ? 208 ALA A O   1 
ATOM   1552 C  CB  . ALA A 1 214 ? 47.78800 -29.28600 27.26000 1.000 39.50058 ? 208 ALA A CB  1 
ATOM   1553 N  N   . GLY A 1 215 ? 47.39000 -26.11400 27.02300 1.000 44.02512 ? 209 GLY A N   1 
ATOM   1554 C  CA  . GLY A 1 215 ? 47.54800 -24.84200 27.70400 1.000 37.63726 ? 209 GLY A CA  1 
ATOM   1555 C  C   . GLY A 1 215 ? 46.75300 -23.70600 27.07600 1.000 43.63146 ? 209 GLY A C   1 
ATOM   1556 O  O   . GLY A 1 215 ? 46.36000 -23.73700 25.90700 1.000 42.64310 ? 209 GLY A O   1 
ATOM   1557 N  N   . ALA A 1 216 ? 46.51500 -22.67400 27.88000 1.000 32.61672 ? 210 ALA A N   1 
ATOM   1558 C  CA  . ALA A 1 216 ? 45.82300 -21.48200 27.42900 1.000 42.84133 ? 210 ALA A CA  1 
ATOM   1559 C  C   . ALA A 1 216 ? 46.71500 -20.63700 26.50400 1.000 43.20651 ? 210 ALA A C   1 
ATOM   1560 O  O   . ALA A 1 216 ? 47.92800 -20.83400 26.40400 1.000 40.67591 ? 210 ALA A O   1 
ATOM   1561 C  CB  . ALA A 1 216 ? 45.37800 -20.66700 28.63700 1.000 36.39305 ? 210 ALA A CB  1 
ATOM   1562 N  N   . CYS A 1 217 ? 46.08600 -19.67700 25.82400 1.000 44.02882 ? 211 CYS A N   1 
ATOM   1563 C  CA  . CYS A 1 217 ? 46.80300 -18.78500 24.91400 1.000 49.45623 ? 211 CYS A CA  1 
ATOM   1564 C  C   . CYS A 1 217 ? 47.89900 -18.00900 25.64400 1.000 49.84900 ? 211 CYS A C   1 
ATOM   1565 O  O   . CYS A 1 217 ? 47.72000 -17.57600 26.78700 1.000 47.08424 ? 211 CYS A O   1 
ATOM   1566 C  CB  . CYS A 1 217 ? 45.81200 -17.82100 24.25100 1.000 47.87415 ? 211 CYS A CB  1 
ATOM   1567 S  SG  . CYS A 1 217 ? 44.56000 -18.66400 23.22600 1.000 53.91181 ? 211 CYS A SG  1 
ATOM   1568 N  N   . GLY A 1 218 ? 49.03500 -17.80900 24.96000 1.000 49.43523 ? 212 GLY A N   1 
ATOM   1569 C  CA  . GLY A 1 218 ? 50.24300 -17.34800 25.63500 1.000 48.89410 ? 212 GLY A CA  1 
ATOM   1570 C  C   . GLY A 1 218 ? 50.32300 -15.86000 25.91400 1.000 49.39835 ? 212 GLY A C   1 
ATOM   1571 O  O   . GLY A 1 218 ? 50.95800 -15.44500 26.89200 1.000 51.26476 ? 212 GLY A O   1 
ATOM   1572 N  N   . GLY A 1 219 ? 49.70200 -15.03500 25.07900 1.000 48.26927 ? 213 GLY A N   1 
ATOM   1573 C  CA  . GLY A 1 219 ? 49.74600 -13.60000 25.27200 1.000 50.86247 ? 213 GLY A CA  1 
ATOM   1574 C  C   . GLY A 1 219 ? 48.86600 -13.12300 26.41800 1.000 47.29347 ? 213 GLY A C   1 
ATOM   1575 O  O   . GLY A 1 219 ? 48.21800 -13.89800 27.12100 1.000 42.75167 ? 213 GLY A O   1 
ATOM   1576 N  N   . MET A 1 220 ? 48.84600 -11.79900 26.59700 1.000 50.94682 ? 214 MET A N   1 
ATOM   1577 C  CA  . MET A 1 220 ? 47.98700 -11.17200 27.59700 1.000 45.25213 ? 214 MET A CA  1 
ATOM   1578 C  C   . MET A 1 220 ? 46.54400 -11.06400 27.12200 1.000 46.84995 ? 214 MET A C   1 
ATOM   1579 O  O   . MET A 1 220 ? 45.92500 -9.99500  27.21400 1.000 42.69665 ? 214 MET A O   1 
ATOM   1580 C  CB  . MET A 1 220 ? 48.51800 -9.78400  27.99500 1.000 45.39666 ? 214 MET A CB  1 
ATOM   1581 C  CG  . MET A 1 220 ? 48.06000 -9.33500  29.39700 1.000 50.42061 ? 214 MET A CG  1 
ATOM   1582 S  SD  . MET A 1 220 ? 48.49000 -10.36600 30.84100 1.000 58.64706 ? 214 MET A SD  1 
ATOM   1583 C  CE  . MET A 1 220 ? 49.93100 -11.20900 30.22300 1.000 42.07201 ? 214 MET A CE  1 
ATOM   1584 N  N   . TYR A 1 221 ? 46.00700 -12.17100 26.61300 1.000 43.41997 ? 215 TYR A N   1 
ATOM   1585 C  CA  . TYR A 1 221 ? 44.59800 -12.25600 26.27600 1.000 44.36945 ? 215 TYR A CA  1 
ATOM   1586 C  C   . TYR A 1 221 ? 43.83200 -12.56300 27.56000 1.000 41.26558 ? 215 TYR A C   1 
ATOM   1587 O  O   . TYR A 1 221 ? 44.38900 -12.50600 28.66100 1.000 37.60631 ? 215 TYR A O   1 
ATOM   1588 C  CB  . TYR A 1 221 ? 44.39000 -13.28900 25.17500 1.000 39.47060 ? 215 TYR A CB  1 
ATOM   1589 C  CG  . TYR A 1 221 ? 44.98200 -12.84200 23.85700 1.000 49.52325 ? 215 TYR A CG  1 
ATOM   1590 C  CD1 . TYR A 1 221 ? 44.29900 -11.95000 23.03300 1.000 51.17723 ? 215 TYR A CD1 1 
ATOM   1591 C  CD2 . TYR A 1 221 ? 46.23600 -13.29600 23.44300 1.000 51.54816 ? 215 TYR A CD2 1 
ATOM   1592 C  CE1 . TYR A 1 221 ? 44.83900 -11.52900 21.82300 1.000 55.08528 ? 215 TYR A CE1 1 
ATOM   1593 C  CE2 . TYR A 1 221 ? 46.78700 -12.88500 22.23700 1.000 51.28464 ? 215 TYR A CE2 1 
ATOM   1594 C  CZ  . TYR A 1 221 ? 46.08600 -12.00300 21.43000 1.000 59.44013 ? 215 TYR A CZ  1 
ATOM   1595 O  OH  . TYR A 1 221 ? 46.63300 -11.59300 20.23100 1.000 59.85278 ? 215 TYR A OH  1 
ATOM   1596 N  N   . THR A 1 222 ? 42.54400 -12.89900 27.43100 1.000 39.37575 ? 216 THR A N   1 
ATOM   1597 C  CA  . THR A 1 222 ? 41.69200 -13.02300 28.61100 1.000 36.93267 ? 216 THR A CA  1 
ATOM   1598 C  C   . THR A 1 222 ? 42.23600 -14.04300 29.60300 1.000 33.40235 ? 216 THR A C   1 
ATOM   1599 O  O   . THR A 1 222 ? 42.26800 -13.78000 30.81100 1.000 34.27048 ? 216 THR A O   1 
ATOM   1600 C  CB  . THR A 1 222 ? 40.26500 -13.37800 28.20000 1.000 37.63614 ? 216 THR A CB  1 
ATOM   1601 O  OG1 . THR A 1 222 ? 39.78600 -12.37300 27.30600 1.000 32.11349 ? 216 THR A OG1 1 
ATOM   1602 C  CG2 . THR A 1 222 ? 39.35400 -13.45400 29.41900 1.000 36.64245 ? 216 THR A CG2 1 
ATOM   1603 N  N   . ALA A 1 223 ? 42.70200 -15.19800 29.12400 1.000 32.90179 ? 217 ALA A N   1 
ATOM   1604 C  CA  . ALA A 1 223 ? 43.14900 -16.23100 30.05800 1.000 37.96725 ? 217 ALA A CA  1 
ATOM   1605 C  C   . ALA A 1 223 ? 44.27400 -15.71600 30.96300 1.000 36.75206 ? 217 ALA A C   1 
ATOM   1606 O  O   . ALA A 1 223 ? 44.15100 -15.73400 32.19200 1.000 32.17106 ? 217 ALA A O   1 
ATOM   1607 C  CB  . ALA A 1 223 ? 43.57900 -17.49300 29.30900 1.000 29.00902 ? 217 ALA A CB  1 
ATOM   1608 N  N   . ASN A 1 224 ? 45.37100 -15.22500 30.37400 1.000 39.09721 ? 218 ASN A N   1 
ATOM   1609 C  CA  . ASN A 1 224 ? 46.50400 -14.80000 31.20300 1.000 39.66267 ? 218 ASN A CA  1 
ATOM   1610 C  C   . ASN A 1 224 ? 46.18700 -13.54000 31.98600 1.000 35.03213 ? 218 ASN A C   1 
ATOM   1611 O  O   . ASN A 1 224 ? 46.64800 -13.38400 33.12700 1.000 33.03894 ? 218 ASN A O   1 
ATOM   1612 C  CB  . ASN A 1 224 ? 47.75200 -14.58700 30.35700 1.000 36.44057 ? 218 ASN A CB  1 
ATOM   1613 C  CG  . ASN A 1 224 ? 48.40600 -15.88400 30.00500 1.000 42.47632 ? 218 ASN A CG  1 
ATOM   1614 O  OD1 . ASN A 1 224 ? 48.29900 -16.85600 30.75600 1.000 40.68690 ? 218 ASN A OD1 1 
ATOM   1615 N  ND2 . ASN A 1 224 ? 49.06600 -15.93000 28.85300 1.000 42.85125 ? 218 ASN A ND2 1 
ATOM   1616 N  N   . THR A 1 225 ? 45.42700 -12.62000 31.38400 1.000 34.06001 ? 219 THR A N   1 
ATOM   1617 C  CA  . THR A 1 225 ? 44.91600 -11.47600 32.13000 1.000 32.27431 ? 219 THR A CA  1 
ATOM   1618 C  C   . THR A 1 225 ? 44.17300 -11.94600 33.36500 1.000 32.79316 ? 219 THR A C   1 
ATOM   1619 O  O   . THR A 1 225 ? 44.47400 -11.52000 34.48900 1.000 27.21838 ? 219 THR A O   1 
ATOM   1620 C  CB  . THR A 1 225 ? 43.98000 -10.62900 31.25300 1.000 37.57116 ? 219 THR A CB  1 
ATOM   1621 O  OG1 . THR A 1 225 ? 44.68200 -10.15100 30.09600 1.000 34.69258 ? 219 THR A OG1 1 
ATOM   1622 C  CG2 . THR A 1 225 ? 43.40900 -9.44000  32.04400 1.000 34.58215 ? 219 THR A CG2 1 
ATOM   1623 N  N   . MET A 1 226 ? 43.19900 -12.84500 33.17900 1.000 27.77435 ? 220 MET A N   1 
ATOM   1624 C  CA  . MET A 1 226 ? 42.38700 -13.25000 34.32300 1.000 26.39200 ? 220 MET A CA  1 
ATOM   1625 C  C   . MET A 1 226 ? 43.18000 -14.09500 35.30900 1.000 22.55582 ? 220 MET A C   1 
ATOM   1626 O  O   . MET A 1 226 ? 43.01900 -13.93300 36.52200 1.000 23.19612 ? 220 MET A O   1 
ATOM   1627 C  CB  . MET A 1 226 ? 41.12600 -13.98300 33.87000 1.000 24.04288 ? 220 MET A CB  1 
ATOM   1628 C  CG  . MET A 1 226 ? 40.15400 -13.05300 33.14800 1.000 26.54510 ? 220 MET A CG  1 
ATOM   1629 S  SD  . MET A 1 226 ? 39.69000 -11.60200 34.12400 1.000 28.85560 ? 220 MET A SD  1 
ATOM   1630 C  CE  . MET A 1 226 ? 39.21500 -12.31700 35.70600 1.000 25.04977 ? 220 MET A CE  1 
ATOM   1631 N  N   . ALA A 1 227 ? 44.02700 -15.01000 34.81700 1.000 23.61872 ? 221 ALA A N   1 
ATOM   1632 C  CA  . ALA A 1 227 ? 44.83100 -15.81300 35.72900 1.000 26.22307 ? 221 ALA A CA  1 
ATOM   1633 C  C   . ALA A 1 227 ? 45.70600 -14.92000 36.60100 1.000 25.77263 ? 221 ALA A C   1 
ATOM   1634 O  O   . ALA A 1 227 ? 45.73900 -15.06700 37.83500 1.000 21.83431 ? 221 ALA A O   1 
ATOM   1635 C  CB  . ALA A 1 227 ? 45.68200 -16.81800 34.95600 1.000 19.11329 ? 221 ALA A CB  1 
ATOM   1636 N  N   . SER A 1 228 ? 46.41600 -13.98000 35.97500 1.000 20.73729 ? 222 SER A N   1 
ATOM   1637 C  CA  . SER A 1 228 ? 47.23300 -13.04500 36.74700 1.000 25.35660 ? 222 SER A CA  1 
ATOM   1638 C  C   . SER A 1 228 ? 46.38100 -12.23400 37.70100 1.000 25.26550 ? 222 SER A C   1 
ATOM   1639 O  O   . SER A 1 228 ? 46.74600 -12.04700 38.87300 1.000 25.23868 ? 222 SER A O   1 
ATOM   1640 C  CB  . SER A 1 228 ? 47.99300 -12.11500 35.80400 1.000 26.82028 ? 222 SER A CB  1 
ATOM   1641 O  OG  . SER A 1 228 ? 49.00600 -12.86100 35.15100 1.000 38.92454 ? 222 SER A OG  1 
ATOM   1642 N  N   . ALA A 1 229 ? 45.24200 -11.73700 37.21200 1.000 22.76762 ? 223 ALA A N   1 
ATOM   1643 C  CA  . ALA A 1 229 ? 44.37300 -10.91800 38.05000 1.000 25.09832 ? 223 ALA A CA  1 
ATOM   1644 C  C   . ALA A 1 229 ? 43.85900 -11.71000 39.24600 1.000 20.55834 ? 223 ALA A C   1 
ATOM   1645 O  O   . ALA A 1 229 ? 43.75400 -11.17000 40.35400 1.000 22.24924 ? 223 ALA A O   1 
ATOM   1646 C  CB  . ALA A 1 229 ? 43.21300 -10.35400 37.21600 1.000 23.21754 ? 223 ALA A CB  1 
ATOM   1647 N  N   . ILE A 1 230 ? 43.56800 -12.99700 39.05500 1.000 19.51302 ? 224 ILE A N   1 
ATOM   1648 C  CA  . ILE A 1 230 ? 43.01000 -13.81000 40.13700 1.000 18.82149 ? 224 ILE A CA  1 
ATOM   1649 C  C   . ILE A 1 230 ? 44.09000 -14.16300 41.16000 1.000 21.86613 ? 224 ILE A C   1 
ATOM   1650 O  O   . ILE A 1 230 ? 43.83100 -14.16500 42.37200 1.000 24.17521 ? 224 ILE A O   1 
ATOM   1651 C  CB  . ILE A 1 230 ? 42.31100 -15.05600 39.55300 1.000 18.93563 ? 224 ILE A CB  1 
ATOM   1652 C  CG1 . ILE A 1 230 ? 41.00200 -14.64000 38.87800 1.000 21.73388 ? 224 ILE A CG1 1 
ATOM   1653 C  CG2 . ILE A 1 230 ? 41.94700 -16.09800 40.64200 1.000 18.61891 ? 224 ILE A CG2 1 
ATOM   1654 C  CD1 . ILE A 1 230 ? 40.47000 -15.63000 37.81700 1.000 22.65039 ? 224 ILE A CD1 1 
ATOM   1655 N  N   . GLU A 1 231 ? 45.31200 -14.43700 40.69900 1.000 23.31826 ? 225 GLU A N   1 
ATOM   1656 C  CA  . GLU A 1 231 ? 46.45500 -14.51500 41.61100 1.000 26.80000 ? 225 GLU A CA  1 
ATOM   1657 C  C   . GLU A 1 231 ? 46.62100 -13.22100 42.39600 1.000 24.75986 ? 225 GLU A C   1 
ATOM   1658 O  O   . GLU A 1 231 ? 46.71600 -13.23600 43.63400 1.000 23.65269 ? 225 GLU A O   1 
ATOM   1659 C  CB  . GLU A 1 231 ? 47.74600 -14.82100 40.84700 1.000 21.43084 ? 225 GLU A CB  1 
ATOM   1660 C  CG  . GLU A 1 231 ? 48.86900 -15.32000 41.78800 1.000 24.26830 ? 225 GLU A CG  1 
ATOM   1661 C  CD  . GLU A 1 231 ? 50.15000 -15.70500 41.06300 1.000 26.20307 ? 225 GLU A CD  1 
ATOM   1662 O  OE1 . GLU A 1 231 ? 50.06900 -16.31900 39.97600 1.000 23.52066 ? 225 GLU A OE1 1 
ATOM   1663 O  OE2 . GLU A 1 231 ? 51.25300 -15.45200 41.61100 1.000 28.43814 ? 225 GLU A OE2 1 
ATOM   1664 N  N   . ALA A 1 232 ? 46.65700 -12.08500 41.68600 1.000 23.28244 ? 226 ALA A N   1 
ATOM   1665 C  CA  . ALA A 1 232 ? 46.79300 -10.79000 42.34600 1.000 21.81950 ? 226 ALA A CA  1 
ATOM   1666 C  C   . ALA A 1 232 ? 45.69100 -10.55900 43.36700 1.000 24.36543 ? 226 ALA A C   1 
ATOM   1667 O  O   . ALA A 1 232 ? 45.91600 -9.89700  44.38900 1.000 23.18278 ? 226 ALA A O   1 
ATOM   1668 C  CB  . ALA A 1 232 ? 46.79200 -9.66700  41.30300 1.000 24.58511 ? 226 ALA A CB  1 
ATOM   1669 N  N   . MET A 1 233 ? 44.49700 -11.10500 43.11500 1.000 23.09079 ? 227 MET A N   1 
ATOM   1670 C  CA  . MET A 1 233 ? 43.36900 -10.97400 44.02700 1.000 23.65232 ? 227 MET A CA  1 
ATOM   1671 C  C   . MET A 1 233 ? 43.49600 -11.90900 45.22200 1.000 24.60245 ? 227 MET A C   1 
ATOM   1672 O  O   . MET A 1 233 ? 42.68900 -11.82600 46.15200 1.000 24.73726 ? 227 MET A O   1 
ATOM   1673 C  CB  . MET A 1 233 ? 42.07900 -11.24500 43.24500 1.000 24.30580 ? 227 MET A CB  1 
ATOM   1674 C  CG  . MET A 1 233 ? 40.76500 -11.01500 43.93900 1.000 24.61337 ? 227 MET A CG  1 
ATOM   1675 S  SD  . MET A 1 233 ? 39.45900 -11.76100 42.92500 1.000 25.63566 ? 227 MET A SD  1 
ATOM   1676 C  CE  . MET A 1 233 ? 39.63300 -10.86600 41.37300 1.000 23.28915 ? 227 MET A CE  1 
ATOM   1677 N  N   . GLY A 1 234 ? 44.50300 -12.77700 45.22200 1.000 22.69795 ? 228 GLY A N   1 
ATOM   1678 C  CA  . GLY A 1 234 ? 44.74300 -13.68300 46.32400 1.000 21.91033 ? 228 GLY A CA  1 
ATOM   1679 C  C   . GLY A 1 234 ? 44.02400 -15.00800 46.25700 1.000 25.99123 ? 228 GLY A C   1 
ATOM   1680 O  O   . GLY A 1 234 ? 44.04700 -15.75200 47.25200 1.000 22.81445 ? 228 GLY A O   1 
ATOM   1681 N  N   . MET A 1 235 ? 43.38700 -15.33900 45.12500 1.000 21.11076 ? 229 MET A N   1 
ATOM   1682 C  CA  . MET A 1 235 ? 42.55700 -16.54100 45.04800 1.000 21.43459 ? 229 MET A CA  1 
ATOM   1683 C  C   . MET A 1 235 ? 43.23300 -17.69700 44.32500 1.000 23.15206 ? 229 MET A C   1 
ATOM   1684 O  O   . MET A 1 235 ? 42.61600 -18.76200 44.16400 1.000 21.41410 ? 229 MET A O   1 
ATOM   1685 C  CB  . MET A 1 235 ? 41.21300 -16.22300 44.38900 1.000 23.38683 ? 229 MET A CB  1 
ATOM   1686 C  CG  . MET A 1 235 ? 40.35800 -15.39500 45.32300 1.000 21.04280 ? 229 MET A CG  1 
ATOM   1687 S  SD  . MET A 1 235 ? 39.74600 -16.31800 46.74700 1.000 25.41657 ? 229 MET A SD  1 
ATOM   1688 C  CE  . MET A 1 235 ? 39.06500 -17.81000 46.01300 1.000 24.05011 ? 229 MET A CE  1 
ATOM   1689 N  N   . SER A 1 236 ? 44.47900 -17.51600 43.90000 1.000 21.76999 ? 230 SER A N   1 
ATOM   1690 C  CA  . SER A 1 236 ? 45.35500 -18.59000 43.45000 1.000 22.79738 ? 230 SER A CA  1 
ATOM   1691 C  C   . SER A 1 236 ? 46.65600 -18.55300 44.24500 1.000 24.65064 ? 230 SER A C   1 
ATOM   1692 O  O   . SER A 1 236 ? 47.06200 -17.50600 44.75000 1.000 25.00577 ? 230 SER A O   1 
ATOM   1693 C  CB  . SER A 1 236 ? 45.69200 -18.47500 41.96300 1.000 20.59603 ? 230 SER A CB  1 
ATOM   1694 O  OG  . SER A 1 236 ? 44.55700 -18.66700 41.16000 1.000 26.98224 ? 230 SER A OG  1 
ATOM   1695 N  N   . LEU A 1 237 ? 47.30700 -19.70800 44.33200 1.000 24.65428 ? 231 LEU A N   1 
ATOM   1696 C  CA  . LEU A 1 237 ? 48.61900 -19.78900 44.96100 1.000 26.21997 ? 231 LEU A CA  1 
ATOM   1697 C  C   . LEU A 1 237 ? 49.65400 -18.99900 44.15600 1.000 28.75475 ? 231 LEU A C   1 
ATOM   1698 O  O   . LEU A 1 237 ? 49.53900 -18.86500 42.93200 1.000 26.27877 ? 231 LEU A O   1 
ATOM   1699 C  CB  . LEU A 1 237 ? 49.05000 -21.25200 45.07200 1.000 26.21840 ? 231 LEU A CB  1 
ATOM   1700 C  CG  . LEU A 1 237 ? 48.14300 -22.05700 46.01000 1.000 23.61376 ? 231 LEU A CG  1 
ATOM   1701 C  CD1 . LEU A 1 237 ? 48.41500 -23.53500 45.88500 1.000 23.30129 ? 231 LEU A CD1 1 
ATOM   1702 C  CD2 . LEU A 1 237 ? 48.31800 -21.59700 47.45700 1.000 27.30965 ? 231 LEU A CD2 1 
ATOM   1703 N  N   . PRO A 1 238 ? 50.68800 -18.47700 44.81500 1.000 28.20828 ? 232 PRO A N   1 
ATOM   1704 C  CA  . PRO A 1 238 ? 51.74500 -17.77200 44.07500 1.000 28.92282 ? 232 PRO A CA  1 
ATOM   1705 C  C   . PRO A 1 238 ? 52.30200 -18.65600 42.96700 1.000 22.97819 ? 232 PRO A C   1 
ATOM   1706 O  O   . PRO A 1 238 ? 52.47200 -19.86400 43.14200 1.000 26.23658 ? 232 PRO A O   1 
ATOM   1707 C  CB  . PRO A 1 238 ? 52.79300 -17.47900 45.16000 1.000 30.84173 ? 232 PRO A CB  1 
ATOM   1708 C  CG  . PRO A 1 238 ? 51.96200 -17.38000 46.42900 1.000 32.77635 ? 232 PRO A CG  1 
ATOM   1709 C  CD  . PRO A 1 238 ? 50.96400 -18.51400 46.26800 1.000 26.78197 ? 232 PRO A CD  1 
ATOM   1710 N  N   . TYR A 1 239 ? 52.53200 -18.05500 41.80000 1.000 22.08645 ? 233 TYR A N   1 
ATOM   1711 C  CA  . TYR A 1 239 ? 53.04900 -18.64900 40.56800 1.000 26.15497 ? 233 TYR A CA  1 
ATOM   1712 C  C   . TYR A 1 239 ? 51.99200 -19.40900 39.76700 1.000 25.24604 ? 233 TYR A C   1 
ATOM   1713 O  O   . TYR A 1 239 ? 52.29400 -19.83800 38.65100 1.000 26.00979 ? 233 TYR A O   1 
ATOM   1714 C  CB  . TYR A 1 239 ? 54.24900 -19.59200 40.78900 1.000 27.79366 ? 233 TYR A CB  1 
ATOM   1715 C  CG  . TYR A 1 239 ? 55.42200 -18.90400 41.44200 1.000 31.50250 ? 233 TYR A CG  1 
ATOM   1716 C  CD1 . TYR A 1 239 ? 56.32100 -18.15100 40.69700 1.000 32.10078 ? 233 TYR A CD1 1 
ATOM   1717 C  CD2 . TYR A 1 239 ? 55.61700 -18.99700 42.80800 1.000 30.55943 ? 233 TYR A CD2 1 
ATOM   1718 C  CE1 . TYR A 1 239 ? 57.38800 -17.51000 41.30200 1.000 34.66043 ? 233 TYR A CE1 1 
ATOM   1719 C  CE2 . TYR A 1 239 ? 56.68400 -18.36400 43.42300 1.000 34.39692 ? 233 TYR A CE2 1 
ATOM   1720 C  CZ  . TYR A 1 239 ? 57.56200 -17.62300 42.66800 1.000 36.24104 ? 233 TYR A CZ  1 
ATOM   1721 O  OH  . TYR A 1 239 ? 58.62300 -16.98800 43.28900 1.000 40.26547 ? 233 TYR A OH  1 
ATOM   1722 N  N   . SER A 1 240 ? 50.78200 -19.61600 40.29100 1.000 24.51399 ? 234 SER A N   1 
ATOM   1723 C  CA  . SER A 1 240 ? 49.76500 -20.33800 39.52700 1.000 27.08881 ? 234 SER A CA  1 
ATOM   1724 C  C   . SER A 1 240 ? 49.61800 -19.76100 38.12400 1.000 21.56392 ? 234 SER A C   1 
ATOM   1725 O  O   . SER A 1 240 ? 49.61200 -20.49400 37.12900 1.000 24.80019 ? 234 SER A O   1 
ATOM   1726 C  CB  . SER A 1 240 ? 48.42100 -20.29200 40.26600 1.000 23.27936 ? 234 SER A CB  1 
ATOM   1727 O  OG  . SER A 1 240 ? 47.55200 -21.26400 39.72400 1.000 24.65972 ? 234 SER A OG  1 
ATOM   1728 N  N   . SER A 1 241 ? 49.54400 -18.43600 38.02200 1.000 22.82927 ? 235 SER A N   1 
ATOM   1729 C  CA  . SER A 1 241 ? 49.28300 -17.84000 36.72000 1.000 25.79473 ? 235 SER A CA  1 
ATOM   1730 C  C   . SER A 1 241 ? 50.46700 -17.94400 35.76300 1.000 28.74859 ? 235 SER A C   1 
ATOM   1731 O  O   . SER A 1 241 ? 50.25500 -17.91300 34.54800 1.000 25.61032 ? 235 SER A O   1 
ATOM   1732 C  CB  . SER A 1 241 ? 48.82900 -16.38300 36.88200 1.000 23.25267 ? 235 SER A CB  1 
ATOM   1733 O  OG  . SER A 1 241 ? 49.79900 -15.57200 37.53100 1.000 26.59921 ? 235 SER A OG  1 
ATOM   1734 N  N   . SER A 1 242 ? 51.70400 -18.10900 36.24500 1.000 27.00820 ? 236 SER A N   1 
ATOM   1735 C  CA  . SER A 1 242 ? 52.82700 -18.03500 35.31600 1.000 28.22886 ? 236 SER A CA  1 
ATOM   1736 C  C   . SER A 1 242 ? 53.52600 -19.36200 35.06100 1.000 32.50331 ? 236 SER A C   1 
ATOM   1737 O  O   . SER A 1 242 ? 54.37300 -19.42100 34.17000 1.000 33.54660 ? 236 SER A O   1 
ATOM   1738 C  CB  . SER A 1 242 ? 53.86700 -16.99100 35.77800 1.000 32.60900 ? 236 SER A CB  1 
ATOM   1739 O  OG  . SER A 1 242 ? 54.07400 -16.99500 37.17800 1.000 30.56854 ? 236 SER A OG  1 
ATOM   1740 N  N   . ILE A 1 243 ? 53.19000 -20.42300 35.78300 1.000 30.56204 ? 237 ILE A N   1 
ATOM   1741 C  CA  . ILE A 1 243 ? 53.75400 -21.74700 35.47800 1.000 29.62058 ? 237 ILE A CA  1 
ATOM   1742 C  C   . ILE A 1 243 ? 53.08300 -22.29600 34.22300 1.000 34.16884 ? 237 ILE A C   1 
ATOM   1743 O  O   . ILE A 1 243 ? 51.84200 -22.36700 34.18000 1.000 31.22171 ? 237 ILE A O   1 
ATOM   1744 C  CB  . ILE A 1 243 ? 53.54900 -22.69800 36.66000 1.000 26.33046 ? 237 ILE A CB  1 
ATOM   1745 C  CG1 . ILE A 1 243 ? 54.31300 -22.21800 37.88700 1.000 28.78782 ? 237 ILE A CG1 1 
ATOM   1746 C  CG2 . ILE A 1 243 ? 53.92600 -24.12300 36.28500 1.000 29.81878 ? 237 ILE A CG2 1 
ATOM   1747 C  CD1 . ILE A 1 243 ? 53.93600 -22.96800 39.14700 1.000 27.27874 ? 237 ILE A CD1 1 
ATOM   1748 N  N   . PRO A 1 244 ? 53.83600 -22.70300 33.19400 1.000 32.93064 ? 238 PRO A N   1 
ATOM   1749 C  CA  . PRO A 1 244 ? 53.20500 -23.26100 31.98700 1.000 30.61651 ? 238 PRO A CA  1 
ATOM   1750 C  C   . PRO A 1 244 ? 52.45400 -24.55600 32.26600 1.000 34.50815 ? 238 PRO A C   1 
ATOM   1751 O  O   . PRO A 1 244 ? 52.76100 -25.30000 33.20300 1.000 27.92315 ? 238 PRO A O   1 
ATOM   1752 C  CB  . PRO A 1 244 ? 54.39800 -23.50400 31.04500 1.000 30.87398 ? 238 PRO A CB  1 
ATOM   1753 C  CG  . PRO A 1 244 ? 55.42500 -22.51000 31.51300 1.000 40.22213 ? 238 PRO A CG  1 
ATOM   1754 C  CD  . PRO A 1 244 ? 55.29100 -22.54600 33.01000 1.000 33.56576 ? 238 PRO A CD  1 
ATOM   1755 N  N   . ALA A 1 245 ? 51.47700 -24.83900 31.39000 1.000 29.32724 ? 239 ALA A N   1 
ATOM   1756 C  CA  . ALA A 1 245 ? 50.56800 -25.96800 31.59700 1.000 31.17059 ? 239 ALA A CA  1 
ATOM   1757 C  C   . ALA A 1 245 ? 51.30100 -27.30600 31.67000 1.000 36.71314 ? 239 ALA A C   1 
ATOM   1758 O  O   . ALA A 1 245 ? 50.91300 -28.19800 32.44100 1.000 29.40630 ? 239 ALA A O   1 
ATOM   1759 C  CB  . ALA A 1 245 ? 49.51900 -26.01200 30.47800 1.000 33.20920 ? 239 ALA A CB  1 
ATOM   1760 N  N   . GLU A 1 246 ? 52.33000 -27.49500 30.85500 1.000 32.38217 ? 240 GLU A N   1 
ATOM   1761 C  CA  . GLU A 1 246 ? 52.97100 -28.80100 30.87300 1.000 42.91441 ? 240 GLU A CA  1 
ATOM   1762 C  C   . GLU A 1 246 ? 54.14400 -28.87100 31.84400 1.000 37.97127 ? 240 GLU A C   1 
ATOM   1763 O  O   . GLU A 1 246 ? 54.79900 -29.91200 31.92300 1.000 43.09732 ? 240 GLU A O   1 
ATOM   1764 C  CB  . GLU A 1 246 ? 53.41100 -29.19300 29.45900 1.000 41.55049 ? 240 GLU A CB  1 
ATOM   1765 C  CG  . GLU A 1 246 ? 52.29100 -29.00800 28.42500 1.000 48.76081 ? 240 GLU A CG  1 
ATOM   1766 C  CD  . GLU A 1 246 ? 52.52300 -29.79100 27.14100 1.000 59.74277 ? 240 GLU A CD  1 
ATOM   1767 O  OE1 . GLU A 1 246 ? 53.68600 -29.86800 26.68300 1.000 59.21085 ? 240 GLU A OE1 1 
ATOM   1768 O  OE2 . GLU A 1 246 ? 51.52700 -30.29800 26.56900 1.000 59.90870 ? 240 GLU A OE2 1 
ATOM   1769 N  N   . ASP A 1 247 ? 54.39700 -27.80100 32.59300 1.000 39.78978 ? 241 ASP A N   1 
ATOM   1770 C  CA  . ASP A 1 247 ? 55.54600 -27.73700 33.48400 1.000 35.06462 ? 241 ASP A CA  1 
ATOM   1771 C  C   . ASP A 1 247 ? 55.33500 -28.66100 34.67900 1.000 34.16673 ? 241 ASP A C   1 
ATOM   1772 O  O   . ASP A 1 247 ? 54.24500 -28.68200 35.26000 1.000 32.54541 ? 241 ASP A O   1 
ATOM   1773 C  CB  . ASP A 1 247 ? 55.75400 -26.30100 33.95500 1.000 33.21123 ? 241 ASP A CB  1 
ATOM   1774 C  CG  . ASP A 1 247 ? 57.12700 -26.07000 34.55500 1.000 38.87913 ? 241 ASP A CG  1 
ATOM   1775 O  OD1 . ASP A 1 247 ? 57.40100 -26.61800 35.64300 1.000 33.71939 ? 241 ASP A OD1 1 
ATOM   1776 O  OD2 . ASP A 1 247 ? 57.92600 -25.31500 33.96000 1.000 41.01851 ? 241 ASP A OD2 1 
ATOM   1777 N  N   . PRO A 1 248 ? 56.34600 -29.44800 35.06000 1.000 35.22823 ? 242 PRO A N   1 
ATOM   1778 C  CA  . PRO A 1 248 ? 56.17500 -30.33800 36.22000 1.000 32.60090 ? 242 PRO A CA  1 
ATOM   1779 C  C   . PRO A 1 248 ? 55.83300 -29.60700 37.50500 1.000 25.17295 ? 242 PRO A C   1 
ATOM   1780 O  O   . PRO A 1 248 ? 55.23700 -30.21500 38.39900 1.000 29.97553 ? 242 PRO A O   1 
ATOM   1781 C  CB  . PRO A 1 248 ? 57.53100 -31.06300 36.30300 1.000 29.18837 ? 242 PRO A CB  1 
ATOM   1782 C  CG  . PRO A 1 248 ? 58.46700 -30.19900 35.51200 1.000 32.19471 ? 242 PRO A CG  1 
ATOM   1783 C  CD  . PRO A 1 248 ? 57.63900 -29.67900 34.39500 1.000 33.80293 ? 242 PRO A CD  1 
ATOM   1784 N  N   . LEU A 1 249 ? 56.14000 -28.31200 37.60300 1.000 26.67060 ? 243 LEU A N   1 
ATOM   1785 C  CA  . LEU A 1 249 ? 55.77700 -27.55000 38.79100 1.000 25.54423 ? 243 LEU A CA  1 
ATOM   1786 C  C   . LEU A 1 249 ? 54.27000 -27.33700 38.88600 1.000 28.15356 ? 243 LEU A C   1 
ATOM   1787 O  O   . LEU A 1 249 ? 53.74000 -27.17500 39.99100 1.000 23.75849 ? 243 LEU A O   1 
ATOM   1788 C  CB  . LEU A 1 249 ? 56.49300 -26.19900 38.79600 1.000 30.68589 ? 243 LEU A CB  1 
ATOM   1789 C  CG  . LEU A 1 249 ? 57.93200 -26.16800 39.33200 1.000 35.09965 ? 243 LEU A CG  1 
ATOM   1790 C  CD1 . LEU A 1 249 ? 58.05600 -26.92000 40.63700 1.000 31.84522 ? 243 LEU A CD1 1 
ATOM   1791 C  CD2 . LEU A 1 249 ? 58.81200 -26.79500 38.33800 1.000 36.16543 ? 243 LEU A CD2 1 
ATOM   1792 N  N   . LYS A 1 250 ? 53.56900 -27.31700 37.74700 1.000 31.64011 ? 244 LYS A N   1 
ATOM   1793 C  CA  . LYS A 1 250 ? 52.10600 -27.22900 37.78400 1.000 29.07924 ? 244 LYS A CA  1 
ATOM   1794 C  C   . LYS A 1 250 ? 51.50400 -28.43200 38.50000 1.000 26.79119 ? 244 LYS A C   1 
ATOM   1795 O  O   . LYS A 1 250 ? 50.59400 -28.28600 39.32700 1.000 25.50443 ? 244 LYS A O   1 
ATOM   1796 C  CB  . LYS A 1 250 ? 51.54700 -27.10900 36.36400 1.000 28.09679 ? 244 LYS A CB  1 
ATOM   1797 C  CG  . LYS A 1 250 ? 49.99500 -27.01400 36.27600 1.000 26.90829 ? 244 LYS A CG  1 
ATOM   1798 C  CD  . LYS A 1 250 ? 49.41000 -25.89300 37.16200 1.000 22.65647 ? 244 LYS A CD  1 
ATOM   1799 C  CE  . LYS A 1 250 ? 49.87700 -24.50900 36.68100 1.000 24.43250 ? 244 LYS A CE  1 
ATOM   1800 N  NZ  . LYS A 1 250 ? 49.28200 -23.39300 37.48500 1.000 22.89673 ? 244 LYS A NZ  1 
ATOM   1801 N  N   . LEU A 1 251 ? 52.01200 -29.63300 38.21100 1.000 27.12741 ? 245 LEU A N   1 
ATOM   1802 C  CA  . LEU A 1 251 ? 51.55300 -30.81500 38.93800 1.000 29.00219 ? 245 LEU A CA  1 
ATOM   1803 C  C   . LEU A 1 251 ? 51.87100 -30.70900 40.42600 1.000 28.92811 ? 245 LEU A C   1 
ATOM   1804 O  O   . LEU A 1 251 ? 51.04000 -31.07000 41.27000 1.000 29.17939 ? 245 LEU A O   1 
ATOM   1805 C  CB  . LEU A 1 251 ? 52.17400 -32.07500 38.34100 1.000 25.74278 ? 245 LEU A CB  1 
ATOM   1806 C  CG  . LEU A 1 251 ? 51.49500 -32.55500 37.05700 1.000 37.87395 ? 245 LEU A CG  1 
ATOM   1807 C  CD1 . LEU A 1 251 ? 52.32600 -33.64300 36.37800 1.000 35.49310 ? 245 LEU A CD1 1 
ATOM   1808 C  CD2 . LEU A 1 251 ? 50.09600 -33.06300 37.35100 1.000 29.34075 ? 245 LEU A CD2 1 
ATOM   1809 N  N   . ASP A 1 252 ? 53.06100 -30.18900 40.77000 1.000 28.93257 ? 246 ASP A N   1 
ATOM   1810 C  CA  . ASP A 1 252 ? 53.40300 -29.97400 42.18000 1.000 25.47454 ? 246 ASP A CA  1 
ATOM   1811 C  C   . ASP A 1 252 ? 52.45700 -28.97200 42.83500 1.000 29.36006 ? 246 ASP A C   1 
ATOM   1812 O  O   . ASP A 1 252 ? 52.03500 -29.16400 43.98200 1.000 25.87514 ? 246 ASP A O   1 
ATOM   1813 C  CB  . ASP A 1 252 ? 54.84500 -29.46600 42.31600 1.000 26.50113 ? 246 ASP A CB  1 
ATOM   1814 C  CG  . ASP A 1 252 ? 55.90600 -30.54900 42.01900 1.000 27.79279 ? 246 ASP A CG  1 
ATOM   1815 O  OD1 . ASP A 1 252 ? 55.55800 -31.70500 41.71900 1.000 23.51303 ? 246 ASP A OD1 1 
ATOM   1816 O  OD2 . ASP A 1 252 ? 57.10400 -30.22200 42.08600 1.000 32.71122 ? 246 ASP A OD2 1 
ATOM   1817 N  N   . GLU A 1 253 ? 52.14300 -27.87000 42.14000 1.000 26.55800 ? 247 GLU A N   1 
ATOM   1818 C  CA  . GLU A 1 253 ? 51.13700 -26.95100 42.66600 1.000 26.49317 ? 247 GLU A CA  1 
ATOM   1819 C  C   . GLU A 1 253 ? 49.83100 -27.68900 42.95100 1.000 24.61750 ? 247 GLU A C   1 
ATOM   1820 O  O   . GLU A 1 253 ? 49.22100 -27.49900 44.01400 1.000 26.24138 ? 247 GLU A O   1 
ATOM   1821 C  CB  . GLU A 1 253 ? 50.90800 -25.79100 41.68900 1.000 26.08936 ? 247 GLU A CB  1 
ATOM   1822 C  CG  . GLU A 1 253 ? 49.93200 -24.72600 42.21600 1.000 23.90987 ? 247 GLU A CG  1 
ATOM   1823 C  CD  . GLU A 1 253 ? 49.35700 -23.83900 41.12000 1.000 25.19948 ? 247 GLU A CD  1 
ATOM   1824 O  OE1 . GLU A 1 253 ? 50.02900 -23.65400 40.08600 1.000 22.23056 ? 247 GLU A OE1 1 
ATOM   1825 O  OE2 . GLU A 1 253 ? 48.25900 -23.27600 41.31700 1.000 24.51689 ? 247 GLU A OE2 1 
ATOM   1826 N  N   . CYS A 1 254 ? 49.40500 -28.56000 42.02300 1.000 25.30941 ? 248 CYS A N   1 
ATOM   1827 C  CA  . CYS A 1 254 ? 48.15400 -29.29900 42.19900 1.000 24.99539 ? 248 CYS A CA  1 
ATOM   1828 C  C   . CYS A 1 254 ? 48.18400 -30.14700 43.45900 1.000 25.97999 ? 248 CYS A C   1 
ATOM   1829 O  O   . CYS A 1 254 ? 47.19100 -30.22000 44.19400 1.000 26.11680 ? 248 CYS A O   1 
ATOM   1830 C  CB  . CYS A 1 254 ? 47.88700 -30.20000 40.98700 1.000 27.04465 ? 248 CYS A CB  1 
ATOM   1831 S  SG  . CYS A 1 254 ? 47.44100 -29.30700 39.44100 1.000 25.83083 ? 248 CYS A SG  1 
ATOM   1832 N  N   . ARG A 1 255 ? 49.31200 -30.82500 43.70700 1.000 28.81568 ? 249 ARG A N   1 
ATOM   1833 C  CA  . ARG A 1 255 ? 49.43200 -31.70100 44.86800 1.000 25.34634 ? 249 ARG A CA  1 
ATOM   1834 C  C   . ARG A 1 255 ? 49.52300 -30.91000 46.16500 1.000 28.70543 ? 249 ARG A C   1 
ATOM   1835 O  O   . ARG A 1 255 ? 49.18000 -31.43500 47.23100 1.000 33.74493 ? 249 ARG A O   1 
ATOM   1836 C  CB  . ARG A 1 255 ? 50.65200 -32.60600 44.68500 1.000 29.37096 ? 249 ARG A CB  1 
ATOM   1837 C  CG  . ARG A 1 255 ? 50.43800 -33.62100 43.58900 1.000 32.63663 ? 249 ARG A CG  1 
ATOM   1838 C  CD  . ARG A 1 255 ? 51.39400 -34.80600 43.63500 1.000 37.13877 ? 249 ARG A CD  1 
ATOM   1839 N  NE  . ARG A 1 255 ? 51.07600 -35.73900 42.55800 1.000 35.71601 ? 249 ARG A NE  1 
ATOM   1840 C  CZ  . ARG A 1 255 ? 51.68400 -35.75500 41.38100 1.000 36.32738 ? 249 ARG A CZ  1 
ATOM   1841 N  NH1 . ARG A 1 255 ? 52.69700 -34.93900 41.11300 1.000 33.61951 ? 249 ARG A NH1 1 
ATOM   1842 N  NH2 . ARG A 1 255 ? 51.26300 -36.60900 40.44600 1.000 38.14207 ? 249 ARG A NH2 1 
ATOM   1843 N  N   . LEU A 1 256 ? 49.92400 -29.64600 46.09200 1.000 25.75776 ? 250 LEU A N   1 
ATOM   1844 C  CA  . LEU A 1 256 ? 49.99900 -28.82100 47.28300 1.000 29.13016 ? 250 LEU A CA  1 
ATOM   1845 C  C   . LEU A 1 256 ? 48.70000 -28.08700 47.59500 1.000 27.17134 ? 250 LEU A C   1 
ATOM   1846 O  O   . LEU A 1 256 ? 48.55400 -27.59300 48.71200 1.000 25.12218 ? 250 LEU A O   1 
ATOM   1847 C  CB  . LEU A 1 256 ? 51.13000 -27.79200 47.13800 1.000 29.36825 ? 250 LEU A CB  1 
ATOM   1848 C  CG  . LEU A 1 256 ? 52.55000 -28.39200 47.23700 1.000 36.23586 ? 250 LEU A CG  1 
ATOM   1849 C  CD1 . LEU A 1 256 ? 53.60300 -27.30700 47.20400 1.000 32.81130 ? 250 LEU A CD1 1 
ATOM   1850 C  CD2 . LEU A 1 256 ? 52.71400 -29.27800 48.47900 1.000 33.01019 ? 250 LEU A CD2 1 
ATOM   1851 N  N   . ALA A 1 257 ? 47.76800 -27.97600 46.64300 1.000 25.19873 ? 251 ALA A N   1 
ATOM   1852 C  CA  . ALA A 1 257 ? 46.57100 -27.19100 46.92600 1.000 27.14089 ? 251 ALA A CA  1 
ATOM   1853 C  C   . ALA A 1 257 ? 45.80600 -27.75900 48.12200 1.000 21.48702 ? 251 ALA A C   1 
ATOM   1854 O  O   . ALA A 1 257 ? 45.20800 -27.00300 48.89200 1.000 22.82024 ? 251 ALA A O   1 
ATOM   1855 C  CB  . ALA A 1 257 ? 45.66900 -27.12600 45.69100 1.000 27.70030 ? 251 ALA A CB  1 
ATOM   1856 N  N   . GLY A 1 258 ? 45.82700 -29.07800 48.29700 1.000 22.18171 ? 252 GLY A N   1 
ATOM   1857 C  CA  . GLY A 1 258 ? 45.09600 -29.67800 49.39700 1.000 23.68104 ? 252 GLY A CA  1 
ATOM   1858 C  C   . GLY A 1 258 ? 45.64300 -29.27000 50.75000 1.000 24.14091 ? 252 GLY A C   1 
ATOM   1859 O  O   . GLY A 1 258 ? 44.87200 -28.99100 51.67500 1.000 24.54207 ? 252 GLY A O   1 
ATOM   1860 N  N   . LYS A 1 259 ? 46.98000 -29.21200 50.87700 1.000 29.11898 ? 253 LYS A N   1 
ATOM   1861 C  CA  . LYS A 1 259 ? 47.60100 -28.73100 52.11200 1.000 26.77501 ? 253 LYS A CA  1 
ATOM   1862 C  C   . LYS A 1 259 ? 47.15600 -27.31100 52.41300 1.000 27.45218 ? 253 LYS A C   1 
ATOM   1863 O  O   . LYS A 1 259 ? 46.77500 -26.98600 53.54200 1.000 26.52650 ? 253 LYS A O   1 
ATOM   1864 C  CB  . LYS A 1 259 ? 49.13200 -28.77100 52.00100 1.000 31.56484 ? 253 LYS A CB  1 
ATOM   1865 C  CG  . LYS A 1 259 ? 49.74200 -30.15900 51.89300 1.000 30.98915 ? 253 LYS A CG  1 
ATOM   1866 C  CD  . LYS A 1 259 ? 49.89300 -30.77800 53.27800 1.000 34.12408 ? 253 LYS A CD  1 
ATOM   1867 C  CE  . LYS A 1 259 ? 50.51000 -32.17100 53.22800 1.000 33.61697 ? 253 LYS A CE  1 
ATOM   1868 N  NZ  . LYS A 1 259 ? 50.60700 -32.71200 54.60800 1.000 32.22246 ? 253 LYS A NZ  1 
ATOM   1869 N  N   . TYR A 1 260 ? 47.21700 -26.44100 51.40800 1.000 25.23861 ? 254 TYR A N   1 
ATOM   1870 C  CA  . TYR A 1 260 ? 46.80400 -25.06000 51.60800 1.000 23.45208 ? 254 TYR A CA  1 
ATOM   1871 C  C   . TYR A 1 260 ? 45.31800 -24.96800 51.91300 1.000 24.10957 ? 254 TYR A C   1 
ATOM   1872 O  O   . TYR A 1 260 ? 44.89400 -24.13500 52.72400 1.000 26.85615 ? 254 TYR A O   1 
ATOM   1873 C  CB  . TYR A 1 260 ? 47.15900 -24.23800 50.37100 1.000 24.41594 ? 254 TYR A CB  1 
ATOM   1874 C  CG  . TYR A 1 260 ? 48.62300 -23.84300 50.31900 1.000 25.11088 ? 254 TYR A CG  1 
ATOM   1875 C  CD1 . TYR A 1 260 ? 49.10100 -22.78000 51.07600 1.000 32.80016 ? 254 TYR A CD1 1 
ATOM   1876 C  CD2 . TYR A 1 260 ? 49.51300 -24.51800 49.49900 1.000 27.24307 ? 254 TYR A CD2 1 
ATOM   1877 C  CE1 . TYR A 1 260 ? 50.43600 -22.40100 51.02300 1.000 34.32553 ? 254 TYR A CE1 1 
ATOM   1878 C  CE2 . TYR A 1 260 ? 50.85100 -24.14800 49.43800 1.000 27.49653 ? 254 TYR A CE2 1 
ATOM   1879 C  CZ  . TYR A 1 260 ? 51.30200 -23.09200 50.20900 1.000 33.60840 ? 254 TYR A CZ  1 
ATOM   1880 O  OH  . TYR A 1 260 ? 52.63100 -22.72300 50.15500 1.000 44.51212 ? 254 TYR A OH  1 
ATOM   1881 N  N   . LEU A 1 261 ? 44.50900 -25.81600 51.28200 1.000 23.23614 ? 255 LEU A N   1 
ATOM   1882 C  CA  . LEU A 1 261 ? 43.07400 -25.77600 51.56600 1.000 24.83500 ? 255 LEU A CA  1 
ATOM   1883 C  C   . LEU A 1 261 ? 42.76800 -26.24600 52.98200 1.000 24.68563 ? 255 LEU A C   1 
ATOM   1884 O  O   . LEU A 1 261 ? 41.87300 -25.70500 53.64000 1.000 19.82267 ? 255 LEU A O   1 
ATOM   1885 C  CB  . LEU A 1 261 ? 42.30100 -26.62300 50.55900 1.000 23.23605 ? 255 LEU A CB  1 
ATOM   1886 C  CG  . LEU A 1 261 ? 40.78300 -26.41400 50.63700 1.000 23.27500 ? 255 LEU A CG  1 
ATOM   1887 C  CD1 . LEU A 1 261 ? 40.38600 -24.93700 50.51400 1.000 21.94014 ? 255 LEU A CD1 1 
ATOM   1888 C  CD2 . LEU A 1 261 ? 40.15100 -27.23800 49.53900 1.000 22.88499 ? 255 LEU A CD2 1 
ATOM   1889 N  N   . LEU A 1 262 ? 43.46800 -27.27800 53.45600 1.000 24.62278 ? 256 LEU A N   1 
ATOM   1890 C  CA  . LEU A 1 262 ? 43.30500 -27.68400 54.85100 1.000 26.74792 ? 256 LEU A CA  1 
ATOM   1891 C  C   . LEU A 1 262 ? 43.48800 -26.49100 55.78700 1.000 26.29851 ? 256 LEU A C   1 
ATOM   1892 O  O   . LEU A 1 262 ? 42.66300 -26.24200 56.67800 1.000 26.57308 ? 256 LEU A O   1 
ATOM   1893 C  CB  . LEU A 1 262 ? 44.30600 -28.79700 55.19800 1.000 27.59354 ? 256 LEU A CB  1 
ATOM   1894 C  CG  . LEU A 1 262 ? 44.29400 -29.29300 56.65600 1.000 31.08653 ? 256 LEU A CG  1 
ATOM   1895 C  CD1 . LEU A 1 262 ? 42.95300 -29.92000 56.99900 1.000 28.79967 ? 256 LEU A CD1 1 
ATOM   1896 C  CD2 . LEU A 1 262 ? 45.42100 -30.30500 56.88300 1.000 30.24772 ? 256 LEU A CD2 1 
ATOM   1897 N  N   . GLU A 1 263 ? 44.56800 -25.73500 55.58300 1.000 26.61601 ? 257 GLU A N   1 
ATOM   1898 C  CA  . GLU A 1 263 ? 44.82600 -24.56400 56.41600 1.000 26.31049 ? 257 GLU A CA  1 
ATOM   1899 C  C   . GLU A 1 263 ? 43.69800 -23.53900 56.29900 1.000 26.91638 ? 257 GLU A C   1 
ATOM   1900 O  O   . GLU A 1 263 ? 43.30100 -22.92900 57.30100 1.000 25.21586 ? 257 GLU A O   1 
ATOM   1901 C  CB  . GLU A 1 263 ? 46.18800 -23.97000 56.03800 1.000 27.68510 ? 257 GLU A CB  1 
ATOM   1902 C  CG  . GLU A 1 263 ? 46.71900 -22.81200 56.89100 1.000 31.51133 ? 257 GLU A CG  1 
ATOM   1903 C  CD  . GLU A 1 263 ? 46.86500 -23.12300 58.39400 1.000 36.73926 ? 257 GLU A CD  1 
ATOM   1904 O  OE1 . GLU A 1 263 ? 46.84700 -24.31300 58.79900 1.000 31.51689 ? 257 GLU A OE1 1 
ATOM   1905 O  OE2 . GLU A 1 263 ? 47.00600 -22.14600 59.16800 1.000 39.71273 ? 257 GLU A OE2 1 
ATOM   1906 N  N   . LEU A 1 264 ? 43.15800 -23.33100 55.08900 1.000 24.93766 ? 258 LEU A N   1 
ATOM   1907 C  CA  . LEU A 1 264 ? 42.03700 -22.39600 54.95200 1.000 23.90562 ? 258 LEU A CA  1 
ATOM   1908 C  C   . LEU A 1 264 ? 40.82500 -22.87200 55.74200 1.000 23.89844 ? 258 LEU A C   1 
ATOM   1909 O  O   . LEU A 1 264 ? 40.08700 -22.06200 56.31400 1.000 26.92187 ? 258 LEU A O   1 
ATOM   1910 C  CB  . LEU A 1 264 ? 41.66300 -22.20900 53.47400 1.000 23.88847 ? 258 LEU A CB  1 
ATOM   1911 C  CG  . LEU A 1 264 ? 42.67500 -21.52000 52.55500 1.000 25.23650 ? 258 LEU A CG  1 
ATOM   1912 C  CD1 . LEU A 1 264 ? 42.08800 -21.29800 51.12900 1.000 25.37424 ? 258 LEU A CD1 1 
ATOM   1913 C  CD2 . LEU A 1 264 ? 43.11600 -20.20300 53.17900 1.000 21.59495 ? 258 LEU A CD2 1 
ATOM   1914 N  N   . LEU A 1 265 ? 40.58300 -24.18300 55.76100 1.000 23.62266 ? 259 LEU A N   1 
ATOM   1915 C  CA  . LEU A 1 265 ? 39.46000 -24.70600 56.53900 1.000 24.24362 ? 259 LEU A CA  1 
ATOM   1916 C  C   . LEU A 1 265 ? 39.67700 -24.51100 58.03200 1.000 25.35578 ? 259 LEU A C   1 
ATOM   1917 O  O   . LEU A 1 265 ? 38.72100 -24.23300 58.76400 1.000 26.28826 ? 259 LEU A O   1 
ATOM   1918 C  CB  . LEU A 1 265 ? 39.24800 -26.18700 56.24100 1.000 23.21280 ? 259 LEU A CB  1 
ATOM   1919 C  CG  . LEU A 1 265 ? 38.77400 -26.48500 54.81300 1.000 24.19931 ? 259 LEU A CG  1 
ATOM   1920 C  CD1 . LEU A 1 265 ? 38.88500 -27.95700 54.52400 1.000 25.01606 ? 259 LEU A CD1 1 
ATOM   1921 C  CD2 . LEU A 1 265 ? 37.33800 -26.04800 54.66000 1.000 20.95005 ? 259 LEU A CD2 1 
ATOM   1922 N  N   . LYS A 1 266 ? 40.92200 -24.68600 58.50200 1.000 25.14757 ? 260 LYS A N   1 
ATOM   1923 C  CA  . LYS A 1 266 ? 41.23800 -24.45600 59.91400 1.000 28.14512 ? 260 LYS A CA  1 
ATOM   1924 C  C   . LYS A 1 266 ? 41.07700 -22.99200 60.28100 1.000 29.03691 ? 260 LYS A C   1 
ATOM   1925 O  O   . LYS A 1 266 ? 40.64900 -22.67500 61.39200 1.000 30.10617 ? 260 LYS A O   1 
ATOM   1926 C  CB  . LYS A 1 266 ? 42.67000 -24.90800 60.22200 1.000 29.70705 ? 260 LYS A CB  1 
ATOM   1927 C  CG  . LYS A 1 266 ? 42.89100 -26.40300 60.22200 1.000 27.38042 ? 260 LYS A CG  1 
ATOM   1928 C  CD  . LYS A 1 266 ? 44.38100 -26.71400 60.32100 1.000 30.22707 ? 260 LYS A CD  1 
ATOM   1929 C  CE  . LYS A 1 266 ? 44.60800 -28.20600 60.44800 1.000 30.16493 ? 260 LYS A CE  1 
ATOM   1930 N  NZ  . LYS A 1 266 ? 46.00500 -28.56900 60.15900 1.000 32.95520 ? 260 LYS A NZ  1 
ATOM   1931 N  N   . MET A 1 267 ? 41.44400 -22.08100 59.37300 1.000 29.32354 ? 261 MET A N   1 
ATOM   1932 C  CA  . MET A 1 267 ? 41.25400 -20.65500 59.62800 1.000 28.92593 ? 261 MET A CA  1 
ATOM   1933 C  C   . MET A 1 267 ? 39.84300 -20.18400 59.31900 1.000 29.97404 ? 261 MET A C   1 
ATOM   1934 O  O   . MET A 1 267 ? 39.48800 -19.06500 59.70100 1.000 28.47263 ? 261 MET A O   1 
ATOM   1935 C  CB  . MET A 1 267 ? 42.22600 -19.81200 58.79300 1.000 28.94419 ? 261 MET A CB  1 
ATOM   1936 C  CG  . MET A 1 267 ? 43.69900 -20.05800 59.04600 1.000 31.85746 ? 261 MET A CG  1 
ATOM   1937 S  SD  . MET A 1 267 ? 44.68800 -19.30200 57.73900 1.000 34.05085 ? 261 MET A SD  1 
ATOM   1938 C  CE  . MET A 1 267 ? 44.31700 -17.59200 58.01600 1.000 28.41063 ? 261 MET A CE  1 
ATOM   1939 N  N   . ASP A 1 268 ? 39.04600 -21.00800 58.64000 1.000 25.97139 ? 262 ASP A N   1 
ATOM   1940 C  CA  . ASP A 1 268 ? 37.79800 -20.58800 58.01500 1.000 22.67134 ? 262 ASP A CA  1 
ATOM   1941 C  C   . ASP A 1 268 ? 37.98400 -19.28100 57.24400 1.000 23.85705 ? 262 ASP A C   1 
ATOM   1942 O  O   . ASP A 1 268 ? 37.18600 -18.34500 57.34800 1.000 28.67549 ? 262 ASP A O   1 
ATOM   1943 C  CB  . ASP A 1 268 ? 36.66300 -20.47600 59.03100 1.000 30.53988 ? 262 ASP A CB  1 
ATOM   1944 C  CG  . ASP A 1 268 ? 35.29900 -20.66200 58.38000 1.000 34.87747 ? 262 ASP A CG  1 
ATOM   1945 O  OD1 . ASP A 1 268 ? 35.17900 -21.57600 57.50700 1.000 30.99521 ? 262 ASP A OD1 1 
ATOM   1946 O  OD2 . ASP A 1 268 ? 34.36300 -19.89200 58.71400 1.000 30.94899 ? 262 ASP A OD2 1 
ATOM   1947 N  N   . LEU A 1 269 ? 39.06700 -19.22400 56.46500 1.000 22.14534 ? 263 LEU A N   1 
ATOM   1948 C  CA  . LEU A 1 269 ? 39.32600 -18.10600 55.56700 1.000 22.76973 ? 263 LEU A CA  1 
ATOM   1949 C  C   . LEU A 1 269 ? 38.58200 -18.36900 54.25900 1.000 25.39728 ? 263 LEU A C   1 
ATOM   1950 O  O   . LEU A 1 269 ? 38.96100 -19.25700 53.48700 1.000 22.98100 ? 263 LEU A O   1 
ATOM   1951 C  CB  . LEU A 1 269 ? 40.82700 -17.93200 55.33800 1.000 23.75098 ? 263 LEU A CB  1 
ATOM   1952 C  CG  . LEU A 1 269 ? 41.30700 -16.66300 54.60200 1.000 25.82999 ? 263 LEU A CG  1 
ATOM   1953 C  CD1 . LEU A 1 269 ? 40.96000 -15.36500 55.36200 1.000 26.68163 ? 263 LEU A CD1 1 
ATOM   1954 C  CD2 . LEU A 1 269 ? 42.79300 -16.72100 54.26500 1.000 26.42961 ? 263 LEU A CD2 1 
ATOM   1955 N  N   . LYS A 1 270 ? 37.53400 -17.60700 54.01400 1.000 24.84499 ? 264 LYS A N   1 
ATOM   1956 C  CA  . LYS A 1 270 ? 36.56800 -17.83100 52.95100 1.000 23.70817 ? 264 LYS A CA  1 
ATOM   1957 C  C   . LYS A 1 270 ? 36.77500 -16.83800 51.80500 1.000 23.93847 ? 264 LYS A C   1 
ATOM   1958 O  O   . LYS A 1 270 ? 37.52400 -15.86300 51.93900 1.000 23.86733 ? 264 LYS A O   1 
ATOM   1959 C  CB  . LYS A 1 270 ? 35.15100 -17.72000 53.53100 1.000 21.23958 ? 264 LYS A CB  1 
ATOM   1960 C  CG  . LYS A 1 270 ? 34.92300 -18.76600 54.63800 1.000 26.07323 ? 264 LYS A CG  1 
ATOM   1961 C  CD  . LYS A 1 270 ? 33.58300 -18.58800 55.36700 1.000 22.82769 ? 264 LYS A CD  1 
ATOM   1962 C  CE  . LYS A 1 270 ? 33.55500 -17.24800 56.08500 1.000 34.95430 ? 264 LYS A CE  1 
ATOM   1963 N  NZ  . LYS A 1 270 ? 34.65700 -17.16500 57.10300 1.000 29.04844 ? 264 LYS A NZ  1 
ATOM   1964 N  N   . PRO A 1 271 ? 36.17400 -17.09600 50.63200 1.000 24.64317 ? 265 PRO A N   1 
ATOM   1965 C  CA  . PRO A 1 271 ? 36.34600 -16.16100 49.50100 1.000 22.48454 ? 265 PRO A CA  1 
ATOM   1966 C  C   . PRO A 1 271 ? 35.93800 -14.72700 49.81300 1.000 22.63003 ? 265 PRO A C   1 
ATOM   1967 O  O   . PRO A 1 271 ? 36.57400 -13.79100 49.31500 1.000 24.49722 ? 265 PRO A O   1 
ATOM   1968 C  CB  . PRO A 1 271 ? 35.45600 -16.78000 48.42000 1.000 24.41069 ? 265 PRO A CB  1 
ATOM   1969 C  CG  . PRO A 1 271 ? 35.56900 -18.29100 48.70800 1.000 22.31386 ? 265 PRO A CG  1 
ATOM   1970 C  CD  . PRO A 1 271 ? 35.52300 -18.35800 50.21100 1.000 24.20591 ? 265 PRO A CD  1 
ATOM   1971 N  N   . ARG A 1 272 ? 34.89300 -14.51700 50.61100 1.000 21.71786 ? 266 ARG A N   1 
ATOM   1972 C  CA  . ARG A 1 272 ? 34.51100 -13.15100 50.93900 1.000 24.00118 ? 266 ARG A CA  1 
ATOM   1973 C  C   . ARG A 1 272 ? 35.42000 -12.52000 51.98800 1.000 28.69099 ? 266 ARG A C   1 
ATOM   1974 O  O   . ARG A 1 272 ? 35.29700 -11.31400 52.23300 1.000 28.12896 ? 266 ARG A O   1 
ATOM   1975 C  CB  . ARG A 1 272 ? 33.06200 -13.11600 51.40700 1.000 24.41766 ? 266 ARG A CB  1 
ATOM   1976 C  CG  . ARG A 1 272 ? 32.08800 -13.46900 50.29700 1.000 26.34286 ? 266 ARG A CG  1 
ATOM   1977 C  CD  . ARG A 1 272 ? 30.63200 -13.33800 50.75100 1.000 28.98606 ? 266 ARG A CD  1 
ATOM   1978 N  NE  . ARG A 1 272 ? 29.74700 -14.11600 49.88700 1.000 28.08211 ? 266 ARG A NE  1 
ATOM   1979 C  CZ  . ARG A 1 272 ? 28.51300 -14.48100 50.21100 1.000 34.55395 ? 266 ARG A CZ  1 
ATOM   1980 N  NH1 . ARG A 1 272 ? 27.98000 -14.15600 51.38000 1.000 30.26994 ? 266 ARG A NH1 1 
ATOM   1981 N  NH2 . ARG A 1 272 ? 27.80000 -15.20400 49.34500 1.000 27.95672 ? 266 ARG A NH2 1 
ATOM   1982 N  N   . ASP A 1 273 ? 36.28700 -13.31300 52.63900 1.000 25.16082 ? 267 ASP A N   1 
ATOM   1983 C  CA  . ASP A 1 273 ? 37.38500 -12.77400 53.43700 1.000 30.10654 ? 267 ASP A CA  1 
ATOM   1984 C  C   . ASP A 1 273 ? 38.57300 -12.37200 52.57100 1.000 31.54691 ? 267 ASP A C   1 
ATOM   1985 O  O   . ASP A 1 273 ? 39.37700 -11.52900 52.98400 1.000 30.94649 ? 267 ASP A O   1 
ATOM   1986 C  CB  . ASP A 1 273 ? 37.87500 -13.80600 54.46500 1.000 23.90564 ? 267 ASP A CB  1 
ATOM   1987 C  CG  . ASP A 1 273 ? 36.76000 -14.33700 55.35500 1.000 29.18334 ? 267 ASP A CG  1 
ATOM   1988 O  OD1 . ASP A 1 273 ? 35.85000 -13.56700 55.72900 1.000 30.85776 ? 267 ASP A OD1 1 
ATOM   1989 O  OD2 . ASP A 1 273 ? 36.80500 -15.54600 55.68100 1.000 27.55564 ? 267 ASP A OD2 1 
ATOM   1990 N  N   . ILE A 1 274 ? 38.70700 -12.97200 51.39200 1.000 28.87655 ? 268 ILE A N   1 
ATOM   1991 C  CA  . ILE A 1 274 ? 39.85500 -12.75000 50.52300 1.000 23.43852 ? 268 ILE A CA  1 
ATOM   1992 C  C   . ILE A 1 274 ? 39.54100 -11.76400 49.40200 1.000 30.82705 ? 268 ILE A C   1 
ATOM   1993 O  O   . ILE A 1 274 ? 40.38500 -10.93000 49.05200 1.000 29.92709 ? 268 ILE A O   1 
ATOM   1994 C  CB  . ILE A 1 274 ? 40.35100 -14.09800 49.95900 1.000 26.72576 ? 268 ILE A CB  1 
ATOM   1995 C  CG1 . ILE A 1 274 ? 40.97900 -14.94200 51.08500 1.000 27.53846 ? 268 ILE A CG1 1 
ATOM   1996 C  CG2 . ILE A 1 274 ? 41.34900 -13.88100 48.82200 1.000 21.95720 ? 268 ILE A CG2 1 
ATOM   1997 C  CD1 . ILE A 1 274 ? 41.18000 -16.42200 50.73300 1.000 22.07316 ? 268 ILE A CD1 1 
ATOM   1998 N  N   . ILE A 1 275 ? 38.34600 -11.85600 48.81900 1.000 21.77731 ? 269 ILE A N   1 
ATOM   1999 C  CA  . ILE A 1 275 ? 37.92400 -10.95800 47.74300 1.000 24.84251 ? 269 ILE A CA  1 
ATOM   2000 C  C   . ILE A 1 275 ? 37.23200 -9.77300  48.39300 1.000 26.29031 ? 269 ILE A C   1 
ATOM   2001 O  O   . ILE A 1 275 ? 36.10100 -9.89700  48.88100 1.000 24.09345 ? 269 ILE A O   1 
ATOM   2002 C  CB  . ILE A 1 275 ? 36.98700 -11.65300 46.74400 1.000 22.91773 ? 269 ILE A CB  1 
ATOM   2003 C  CG1 . ILE A 1 275 ? 37.64400 -12.89000 46.14400 1.000 20.23473 ? 269 ILE A CG1 1 
ATOM   2004 C  CG2 . ILE A 1 275 ? 36.54500 -10.71000 45.63200 1.000 19.99529 ? 269 ILE A CG2 1 
ATOM   2005 C  CD1 . ILE A 1 275 ? 36.64700 -13.78600 45.39600 1.000 23.30791 ? 269 ILE A CD1 1 
ATOM   2006 N  N   . THR A 1 276 ? 37.92500 -8.62600  48.41200 1.000 24.21136 ? 270 THR A N   1 
ATOM   2007 C  CA  . THR A 1 276 ? 37.48700 -7.42300  49.10600 1.000 27.33829 ? 270 THR A CA  1 
ATOM   2008 C  C   . THR A 1 276 ? 37.68500 -6.23000  48.17500 1.000 25.36351 ? 270 THR A C   1 
ATOM   2009 O  O   . THR A 1 276 ? 38.31900 -6.37600  47.12100 1.000 23.82923 ? 270 THR A O   1 
ATOM   2010 C  CB  . THR A 1 276 ? 38.28300 -7.23600  50.39700 1.000 26.03429 ? 270 THR A CB  1 
ATOM   2011 O  OG1 . THR A 1 276 ? 39.67200 -7.05600  50.07700 1.000 23.07168 ? 270 THR A OG1 1 
ATOM   2012 C  CG2 . THR A 1 276 ? 38.13800 -8.45100  51.30600 1.000 23.36273 ? 270 THR A CG2 1 
ATOM   2013 N  N   . PRO A 1 277 ? 37.18900 -5.03500  48.52100 1.000 24.98748 ? 271 PRO A N   1 
ATOM   2014 C  CA  . PRO A 1 277 ? 37.48200 -3.86800  47.66600 1.000 25.07468 ? 271 PRO A CA  1 
ATOM   2015 C  C   . PRO A 1 277 ? 38.96000 -3.72400  47.34200 1.000 29.27480 ? 271 PRO A C   1 
ATOM   2016 O  O   . PRO A 1 277 ? 39.34600 -3.40400  46.21400 1.000 27.67262 ? 271 PRO A O   1 
ATOM   2017 C  CB  . PRO A 1 277 ? 36.95700 -2.70100  48.50800 1.000 27.94860 ? 271 PRO A CB  1 
ATOM   2018 C  CG  . PRO A 1 277 ? 35.78500 -3.29100  49.24400 1.000 24.96350 ? 271 PRO A CG  1 
ATOM   2019 C  CD  . PRO A 1 277 ? 36.23700 -4.69200  49.60000 1.000 23.60936 ? 271 PRO A CD  1 
ATOM   2020 N  N   . LYS A 1 278 ? 39.80500 -4.05700  48.29700 1.000 30.75652 ? 272 LYS A N   1 
ATOM   2021 C  CA  . LYS A 1 278 ? 41.21700 -3.76800  48.14600 1.000 27.11245 ? 272 LYS A CA  1 
ATOM   2022 C  C   . LYS A 1 278 ? 41.93100 -4.85400  47.33200 1.000 28.65807 ? 272 LYS A C   1 
ATOM   2023 O  O   . LYS A 1 278 ? 42.79600 -4.55100  46.50300 1.000 27.71009 ? 272 LYS A O   1 
ATOM   2024 C  CB  . LYS A 1 278 ? 41.72300 -3.58800  49.55800 1.000 33.41523 ? 272 LYS A CB  1 
ATOM   2025 C  CG  . LYS A 1 278 ? 41.67300 -2.13300  49.87800 1.000 38.49430 ? 272 LYS A CG  1 
ATOM   2026 C  CD  . LYS A 1 278 ? 42.14600 -1.89800  51.29500 1.000 52.18581 ? 272 LYS A CD  1 
ATOM   2027 C  CE  . LYS A 1 278 ? 43.56800 -2.14300  51.41900 1.000 54.65445 ? 272 LYS A CE  1 
ATOM   2028 N  NZ  . LYS A 1 278 ? 44.38700 -0.97200  50.88800 1.000 63.84053 ? 272 LYS A NZ  1 
ATOM   2029 N  N   . SER A 1 279 ? 41.52500 -6.12100  47.49200 1.000 27.94633 ? 273 SER A N   1 
ATOM   2030 C  CA  . SER A 1 279 ? 42.07600 -7.17400  46.63800 1.000 28.52351 ? 273 SER A CA  1 
ATOM   2031 C  C   . SER A 1 279 ? 41.52000 -7.09200  45.22200 1.000 26.53220 ? 273 SER A C   1 
ATOM   2032 O  O   . SER A 1 279 ? 42.23000 -7.43200  44.26400 1.000 26.70210 ? 273 SER A O   1 
ATOM   2033 C  CB  . SER A 1 279 ? 41.81800 -8.55900  47.24700 1.000 24.99800 ? 273 SER A CB  1 
ATOM   2034 O  OG  . SER A 1 279 ? 40.44200 -8.89800  47.22300 1.000 25.16524 ? 273 SER A OG  1 
ATOM   2035 N  N   . LEU A 1 280 ? 40.27600 -6.61600  45.06800 1.000 23.12123 ? 274 LEU A N   1 
ATOM   2036 C  CA  . LEU A 1 280 ? 39.76300 -6.31600  43.73200 1.000 27.02260 ? 274 LEU A CA  1 
ATOM   2037 C  C   . LEU A 1 280 ? 40.58600 -5.21800  43.07400 1.000 28.69312 ? 274 LEU A C   1 
ATOM   2038 O  O   . LEU A 1 280 ? 40.87800 -5.28200  41.87400 1.000 25.16862 ? 274 LEU A O   1 
ATOM   2039 C  CB  . LEU A 1 280 ? 38.28300 -5.91000  43.80000 1.000 27.77953 ? 274 LEU A CB  1 
ATOM   2040 C  CG  . LEU A 1 280 ? 37.22300 -6.98200  44.11600 1.000 22.91678 ? 274 LEU A CG  1 
ATOM   2041 C  CD1 . LEU A 1 280 ? 35.89400 -6.33500  44.53400 1.000 22.49134 ? 274 LEU A CD1 1 
ATOM   2042 C  CD2 . LEU A 1 280 ? 37.00300 -7.93500  42.94000 1.000 22.48178 ? 274 LEU A CD2 1 
ATOM   2043 N  N   . ARG A 1 281 ? 40.98700 -4.20300  43.84700 1.000 28.43018 ? 275 ARG A N   1 
ATOM   2044 C  CA  . ARG A 1 281 ? 41.86200 -3.18400  43.28500 1.000 29.18794 ? 275 ARG A CA  1 
ATOM   2045 C  C   . ARG A 1 281 ? 43.22400 -3.77200  42.92200 1.000 30.33720 ? 275 ARG A C   1 
ATOM   2046 O  O   . ARG A 1 281 ? 43.77200 -3.46800  41.85700 1.000 29.72597 ? 275 ARG A O   1 
ATOM   2047 C  CB  . ARG A 1 281 ? 42.01700 -2.01000  44.25700 1.000 29.95538 ? 275 ARG A CB  1 
ATOM   2048 C  CG  . ARG A 1 281 ? 42.81900 -0.85900  43.64400 1.000 35.81055 ? 275 ARG A CG  1 
ATOM   2049 C  CD  . ARG A 1 281 ? 42.93600 0.36300   44.56300 1.000 37.89912 ? 275 ARG A CD  1 
ATOM   2050 N  NE  . ARG A 1 281 ? 43.49800 1.50600   43.84600 1.000 51.39474 ? 275 ARG A NE  1 
ATOM   2051 C  CZ  . ARG A 1 281 ? 44.76500 1.62300   43.45200 1.000 56.60722 ? 275 ARG A CZ  1 
ATOM   2052 N  NH1 . ARG A 1 281 ? 45.67100 0.70300   43.74600 1.000 48.18825 ? 275 ARG A NH1 1 
ATOM   2053 N  NH2 . ARG A 1 281 ? 45.13400 2.69700   42.74900 1.000 49.96839 ? 275 ARG A NH2 1 
ATOM   2054 N  N   . ASN A 1 282 ? 43.77900 -4.62800  43.79400 1.000 27.82226 ? 276 ASN A N   1 
ATOM   2055 C  CA  . ASN A 1 282 ? 45.01900 -5.32900  43.47100 1.000 27.74099 ? 276 ASN A CA  1 
ATOM   2056 C  C   . ASN A 1 282 ? 44.90500 -6.05900  42.13800 1.000 29.81813 ? 276 ASN A C   1 
ATOM   2057 O  O   . ASN A 1 282 ? 45.82700 -6.01600  41.30600 1.000 25.95076 ? 276 ASN A O   1 
ATOM   2058 C  CB  . ASN A 1 282 ? 45.36900 -6.32600  44.58000 1.000 27.63338 ? 276 ASN A CB  1 
ATOM   2059 C  CG  . ASN A 1 282 ? 45.94200 -5.65600  45.82400 1.000 32.10828 ? 276 ASN A CG  1 
ATOM   2060 O  OD1 . ASN A 1 282 ? 46.33400 -4.48600  45.79700 1.000 27.22329 ? 276 ASN A OD1 1 
ATOM   2061 N  ND2 . ASN A 1 282 ? 45.99400 -6.40500  46.92100 1.000 28.52860 ? 276 ASN A ND2 1 
ATOM   2062 N  N   . ALA A 1 283 ? 43.77800 -6.74700  41.92100 1.000 25.50986 ? 277 ALA A N   1 
ATOM   2063 C  CA  . ALA A 1 283 ? 43.57400 -7.43200  40.64900 1.000 28.80138 ? 277 ALA A CA  1 
ATOM   2064 C  C   . ALA A 1 283 ? 43.57700 -6.44000  39.49100 1.000 26.02906 ? 277 ALA A C   1 
ATOM   2065 O  O   . ALA A 1 283 ? 44.19000 -6.69000  38.44600 1.000 27.18550 ? 277 ALA A O   1 
ATOM   2066 C  CB  . ALA A 1 283 ? 42.26100 -8.22000  40.68600 1.000 22.59870 ? 277 ALA A CB  1 
ATOM   2067 N  N   . MET A 1 284 ? 42.88000 -5.31100  39.65900 1.000 26.30530 ? 278 MET A N   1 
ATOM   2068 C  CA  . MET A 1 284 ? 42.81700 -4.30600  38.60000 1.000 26.92083 ? 278 MET A CA  1 
ATOM   2069 C  C   . MET A 1 284 ? 44.18100 -3.68100  38.33500 1.000 30.08222 ? 278 MET A C   1 
ATOM   2070 O  O   . MET A 1 284 ? 44.51200 -3.36400  37.18400 1.000 27.96306 ? 278 MET A O   1 
ATOM   2071 C  CB  . MET A 1 284 ? 41.80200 -3.23300  38.97600 1.000 25.31435 ? 278 MET A CB  1 
ATOM   2072 C  CG  . MET A 1 284 ? 40.38600 -3.74600  38.98300 1.000 29.09190 ? 278 MET A CG  1 
ATOM   2073 S  SD  . MET A 1 284 ? 39.28200 -2.75000  39.98400 1.000 39.72998 ? 278 MET A SD  1 
ATOM   2074 C  CE  . MET A 1 284 ? 38.67800 -1.65300  38.74400 1.000 25.21883 ? 278 MET A CE  1 
ATOM   2075 N  N   . VAL A 1 285 ? 44.97200 -3.46600  39.39200 1.000 29.04211 ? 279 VAL A N   1 
ATOM   2076 C  CA  . VAL A 1 285 ? 46.32100 -2.94100  39.20800 1.000 31.25667 ? 279 VAL A CA  1 
ATOM   2077 C  C   . VAL A 1 285 ? 47.12300 -3.86500  38.31200 1.000 29.28700 ? 279 VAL A C   1 
ATOM   2078 O  O   . VAL A 1 285 ? 47.82600 -3.41500  37.39300 1.000 31.55516 ? 279 VAL A O   1 
ATOM   2079 C  CB  . VAL A 1 285 ? 47.00800 -2.73300  40.57400 1.000 32.29708 ? 279 VAL A CB  1 
ATOM   2080 C  CG1 . VAL A 1 285 ? 48.49500 -2.50400  40.39700 1.000 29.19421 ? 279 VAL A CG1 1 
ATOM   2081 C  CG2 . VAL A 1 285 ? 46.36800 -1.56500  41.30300 1.000 29.39108 ? 279 VAL A CG2 1 
ATOM   2082 N  N   . SER A 1 286 ? 47.01600 -5.17200  38.55300 1.000 29.72746 ? 280 SER A N   1 
ATOM   2083 C  CA  . SER A 1 286 ? 47.72400 -6.15300  37.73300 1.000 31.77187 ? 280 SER A CA  1 
ATOM   2084 C  C   . SER A 1 286 ? 47.28000 -6.09000  36.27400 1.000 31.61468 ? 280 SER A C   1 
ATOM   2085 O  O   . SER A 1 286 ? 48.10500 -6.21300  35.36100 1.000 32.47946 ? 280 SER A O   1 
ATOM   2086 C  CB  . SER A 1 286 ? 47.51400 -7.55200  38.32900 1.000 30.44502 ? 280 SER A CB  1 
ATOM   2087 O  OG  . SER A 1 286 ? 46.25600 -8.09900  37.95100 1.000 34.80348 ? 280 SER A OG  1 
ATOM   2088 N  N   . VAL A 1 287 ? 45.97900 -5.89200  36.03300 1.000 31.72657 ? 281 VAL A N   1 
ATOM   2089 C  CA  . VAL A 1 287 ? 45.48800 -5.75300  34.66400 1.000 28.80493 ? 281 VAL A CA  1 
ATOM   2090 C  C   . VAL A 1 287 ? 46.11000 -4.53400  33.99000 1.000 29.52597 ? 281 VAL A C   1 
ATOM   2091 O  O   . VAL A 1 287 ? 46.62100 -4.62000  32.86500 1.000 28.42640 ? 281 VAL A O   1 
ATOM   2092 C  CB  . VAL A 1 287 ? 43.95000 -5.67600  34.65100 1.000 30.04212 ? 281 VAL A CB  1 
ATOM   2093 C  CG1 . VAL A 1 287 ? 43.45400 -5.38700  33.22600 1.000 23.82047 ? 281 VAL A CG1 1 
ATOM   2094 C  CG2 . VAL A 1 287 ? 43.33000 -6.98900  35.22600 1.000 22.77047 ? 281 VAL A CG2 1 
ATOM   2095 N  N   . MET A 1 288 ? 46.02000 -3.37000  34.64700 1.000 28.98134 ? 282 MET A N   1 
ATOM   2096 C  CA  . MET A 1 288 ? 46.58700 -2.13900  34.09800 1.000 32.77672 ? 282 MET A CA  1 
ATOM   2097 C  C   . MET A 1 288 ? 48.07100 -2.31000  33.80100 1.000 30.16351 ? 282 MET A C   1 
ATOM   2098 O  O   . MET A 1 288 ? 48.53600 -2.00800  32.69700 1.000 33.41341 ? 282 MET A O   1 
ATOM   2099 C  CB  . MET A 1 288 ? 46.37900 -0.98500  35.08400 1.000 29.97894 ? 282 MET A CB  1 
ATOM   2100 C  CG  . MET A 1 288 ? 44.94800 -0.50400  35.25200 1.000 33.68910 ? 282 MET A CG  1 
ATOM   2101 S  SD  . MET A 1 288 ? 43.87300 -0.80700  33.83400 1.000 33.49341 ? 282 MET A SD  1 
ATOM   2102 C  CE  . MET A 1 288 ? 42.24300 -0.66900  34.59000 1.000 34.44080 ? 282 MET A CE  1 
ATOM   2103 N  N   . ALA A 1 289 ? 48.83000 -2.81200  34.78100 1.000 33.36489 ? 283 ALA A N   1 
ATOM   2104 C  CA  . ALA A 1 289 ? 50.27900 -2.88600  34.63300 1.000 35.55562 ? 283 ALA A CA  1 
ATOM   2105 C  C   . ALA A 1 289 ? 50.70400 -3.87300  33.55000 1.000 37.29589 ? 283 ALA A C   1 
ATOM   2106 O  O   . ALA A 1 289 ? 51.71100 -3.64300  32.87100 1.000 38.93844 ? 283 ALA A O   1 
ATOM   2107 C  CB  . ALA A 1 289 ? 50.92000 -3.24900  35.97300 1.000 30.35450 ? 283 ALA A CB  1 
ATOM   2108 N  N   . LEU A 1 290 ? 49.96300 -4.96600  33.36200 1.000 32.64110 ? 284 LEU A N   1 
ATOM   2109 C  CA  . LEU A 1 290 ? 50.33800 -5.96400  32.36600 1.000 34.14106 ? 284 LEU A CA  1 
ATOM   2110 C  C   . LEU A 1 290 ? 49.71300 -5.71600  30.99600 1.000 35.26441 ? 284 LEU A C   1 
ATOM   2111 O  O   . LEU A 1 290 ? 49.95700 -6.50500  30.07900 1.000 33.67511 ? 284 LEU A O   1 
ATOM   2112 C  CB  . LEU A 1 290 ? 49.95800 -7.37400  32.85300 1.000 38.05017 ? 284 LEU A CB  1 
ATOM   2113 C  CG  . LEU A 1 290 ? 50.74800 -7.89800  34.05700 1.000 36.52894 ? 284 LEU A CG  1 
ATOM   2114 C  CD1 . LEU A 1 290 ? 50.01600 -9.04800  34.74700 1.000 33.60798 ? 284 LEU A CD1 1 
ATOM   2115 C  CD2 . LEU A 1 290 ? 52.14300 -8.33600  33.64600 1.000 36.98622 ? 284 LEU A CD2 1 
ATOM   2116 N  N   . GLY A 1 291 ? 48.93400 -4.64900  30.82900 1.000 33.38966 ? 285 GLY A N   1 
ATOM   2117 C  CA  . GLY A 1 291 ? 48.19400 -4.44000  29.59200 1.000 35.31519 ? 285 GLY A CA  1 
ATOM   2118 C  C   . GLY A 1 291 ? 47.12800 -5.49000  29.34300 1.000 40.90770 ? 285 GLY A C   1 
ATOM   2119 O  O   . GLY A 1 291 ? 46.99200 -5.98500  28.21800 1.000 37.66332 ? 285 GLY A O   1 
ATOM   2120 N  N   . GLY A 1 292 ? 46.37800 -5.86100  30.38200 1.000 38.44845 ? 286 GLY A N   1 
ATOM   2121 C  CA  . GLY A 1 292 ? 45.44700 -6.96300  30.27500 1.000 35.09215 ? 286 GLY A CA  1 
ATOM   2122 C  C   . GLY A 1 292 ? 44.20900 -6.62400  29.46500 1.000 39.23548 ? 286 GLY A C   1 
ATOM   2123 O  O   . GLY A 1 292 ? 43.91400 -5.46700  29.16500 1.000 27.60696 ? 286 GLY A O   1 
ATOM   2124 N  N   . SER A 1 293 ? 43.45500 -7.68300  29.16400 1.000 36.44994 ? 287 SER A N   1 
ATOM   2125 C  CA  . SER A 1 293 ? 42.31200 -7.62700  28.26100 1.000 33.03838 ? 287 SER A CA  1 
ATOM   2126 C  C   . SER A 1 293 ? 41.18500 -6.74000  28.78100 1.000 33.93684 ? 287 SER A C   1 
ATOM   2127 O  O   . SER A 1 293 ? 40.88000 -6.72700  29.98000 1.000 31.62301 ? 287 SER A O   1 
ATOM   2128 C  CB  . SER A 1 293 ? 41.76700 -9.04800  28.04300 1.000 31.51009 ? 287 SER A CB  1 
ATOM   2129 O  OG  . SER A 1 293 ? 40.64000 -9.02600  27.17800 1.000 32.71075 ? 287 SER A OG  1 
ATOM   2130 N  N   . THR A 1 294 ? 40.51300 -6.04900  27.84600 1.000 26.03602 ? 288 THR A N   1 
ATOM   2131 C  CA  . THR A 1 294 ? 39.25300 -5.38100  28.15700 1.000 27.28430 ? 288 THR A CA  1 
ATOM   2132 C  C   . THR A 1 294 ? 38.17600 -6.35700  28.64600 1.000 24.43106 ? 288 THR A C   1 
ATOM   2133 O  O   . THR A 1 294 ? 37.23300 -5.93900  29.32900 1.000 23.05460 ? 288 THR A O   1 
ATOM   2134 C  CB  . THR A 1 294 ? 38.72200 -4.63400  26.92600 1.000 26.15367 ? 288 THR A CB  1 
ATOM   2135 O  OG1 . THR A 1 294 ? 38.58100 -5.54800  25.83400 1.000 26.91820 ? 288 THR A OG1 1 
ATOM   2136 C  CG2 . THR A 1 294 ? 39.67000 -3.53200  26.51100 1.000 30.61232 ? 288 THR A CG2 1 
ATOM   2137 N  N   . ASN A 1 295 ? 38.26600 -7.64300  28.30600 1.000 21.90540 ? 289 ASN A N   1 
ATOM   2138 C  CA  . ASN A 1 295 ? 37.30200 -8.58000  28.88800 1.000 26.76972 ? 289 ASN A CA  1 
ATOM   2139 C  C   . ASN A 1 295 ? 37.40200 -8.64400  30.41100 1.000 26.97102 ? 289 ASN A C   1 
ATOM   2140 O  O   . ASN A 1 295 ? 36.42200 -9.01200  31.06700 1.000 23.87616 ? 289 ASN A O   1 
ATOM   2141 C  CB  . ASN A 1 295 ? 37.48100 -9.97600  28.28500 1.000 24.33353 ? 289 ASN A CB  1 
ATOM   2142 C  CG  . ASN A 1 295 ? 37.08200 -10.02000 26.83300 1.000 30.06073 ? 289 ASN A CG  1 
ATOM   2143 O  OD1 . ASN A 1 295 ? 36.03300 -9.49300  26.44200 1.000 30.22610 ? 289 ASN A OD1 1 
ATOM   2144 N  ND2 . ASN A 1 295 ? 37.93000 -10.60900 26.01500 1.000 28.26811 ? 289 ASN A ND2 1 
ATOM   2145 N  N   . ALA A 1 296 ? 38.54800 -8.25600  30.98900 1.000 25.52640 ? 290 ALA A N   1 
ATOM   2146 C  CA  . ALA A 1 296 ? 38.69200 -8.27200  32.44400 1.000 25.32923 ? 290 ALA A CA  1 
ATOM   2147 C  C   . ALA A 1 296 ? 37.74300 -7.29100  33.11500 1.000 25.61061 ? 290 ALA A C   1 
ATOM   2148 O  O   . ALA A 1 296 ? 37.37900 -7.48100  34.27900 1.000 27.78727 ? 290 ALA A O   1 
ATOM   2149 C  CB  . ALA A 1 296 ? 40.13600 -7.95700  32.84700 1.000 29.40230 ? 290 ALA A CB  1 
ATOM   2150 N  N   . VAL A 1 297 ? 37.33500 -6.23400  32.41300 1.000 22.72064 ? 291 VAL A N   1 
ATOM   2151 C  CA  . VAL A 1 297 ? 36.29100 -5.37100  32.94900 1.000 24.14111 ? 291 VAL A CA  1 
ATOM   2152 C  C   . VAL A 1 297 ? 35.03200 -6.18400  33.23200 1.000 22.74909 ? 291 VAL A C   1 
ATOM   2153 O  O   . VAL A 1 297 ? 34.45900 -6.10200  34.32500 1.000 20.69601 ? 291 VAL A O   1 
ATOM   2154 C  CB  . VAL A 1 297 ? 36.00100 -4.19900  31.99400 1.000 24.96465 ? 291 VAL A CB  1 
ATOM   2155 C  CG1 . VAL A 1 297 ? 34.79100 -3.44200  32.47800 1.000 26.46265 ? 291 VAL A CG1 1 
ATOM   2156 C  CG2 . VAL A 1 297 ? 37.23100 -3.26600  31.86800 1.000 27.71337 ? 291 VAL A CG2 1 
ATOM   2157 N  N   . LEU A 1 298 ? 34.58800 -6.99400  32.25300 1.000 21.36633 ? 292 LEU A N   1 
ATOM   2158 C  CA  . LEU A 1 298 ? 33.37900 -7.79400  32.46400 1.000 24.69523 ? 292 LEU A CA  1 
ATOM   2159 C  C   . LEU A 1 298 ? 33.57800 -8.78700  33.60300 1.000 20.84571 ? 292 LEU A C   1 
ATOM   2160 O  O   . LEU A 1 298 ? 32.71800 -8.93100  34.47800 1.000 21.43205 ? 292 LEU A O   1 
ATOM   2161 C  CB  . LEU A 1 298 ? 32.98600 -8.53900  31.18200 1.000 24.38676 ? 292 LEU A CB  1 
ATOM   2162 C  CG  . LEU A 1 298 ? 32.68700 -7.75500  29.89400 1.000 24.74720 ? 292 LEU A CG  1 
ATOM   2163 C  CD1 . LEU A 1 298 ? 32.42000 -8.67700  28.70400 1.000 23.25553 ? 292 LEU A CD1 1 
ATOM   2164 C  CD2 . LEU A 1 298 ? 31.51900 -6.79400  30.12700 1.000 23.30971 ? 292 LEU A CD2 1 
ATOM   2165 N  N   . HIS A 1 299 ? 34.71600 -9.46500  33.61700 1.000 20.36807 ? 293 HIS A N   1 
ATOM   2166 C  CA  . HIS A 1 299 ? 34.86900 -10.58700 34.53500 1.000 22.31543 ? 293 HIS A CA  1 
ATOM   2167 C  C   . HIS A 1 299 ? 35.12600 -10.11500 35.96600 1.000 21.47221 ? 293 HIS A C   1 
ATOM   2168 O  O   . HIS A 1 299 ? 34.63200 -10.72100 36.92700 1.000 19.05530 ? 293 HIS A O   1 
ATOM   2169 C  CB  . HIS A 1 299 ? 35.98600 -11.48800 34.02100 1.000 21.56958 ? 293 HIS A CB  1 
ATOM   2170 C  CG  . HIS A 1 299 ? 35.71900 -12.01800 32.64600 1.000 24.67585 ? 293 HIS A CG  1 
ATOM   2171 N  ND1 . HIS A 1 299 ? 34.45000 -12.33600 32.21500 1.000 19.04301 ? 293 HIS A ND1 1 
ATOM   2172 C  CD2 . HIS A 1 299 ? 36.54200 -12.26500 31.60200 1.000 23.45871 ? 293 HIS A CD2 1 
ATOM   2173 C  CE1 . HIS A 1 299 ? 34.50200 -12.77000 30.97000 1.000 22.23819 ? 293 HIS A CE1 1 
ATOM   2174 N  NE2 . HIS A 1 299 ? 35.76100 -12.74800 30.57700 1.000 18.71452 ? 293 HIS A NE2 1 
ATOM   2175 N  N   . LEU A 1 300 ? 35.88100 -9.02800  36.13800 1.000 20.53804 ? 294 LEU A N   1 
ATOM   2176 C  CA  . LEU A 1 300 ? 36.10900 -8.55000  37.49900 1.000 20.90576 ? 294 LEU A CA  1 
ATOM   2177 C  C   . LEU A 1 300 ? 34.84600 -7.93400  38.08000 1.000 22.43208 ? 294 LEU A C   1 
ATOM   2178 O  O   . LEU A 1 300 ? 34.58900 -8.07200  39.28300 1.000 20.06982 ? 294 LEU A O   1 
ATOM   2179 C  CB  . LEU A 1 300 ? 37.27400 -7.56400  37.52400 1.000 20.32468 ? 294 LEU A CB  1 
ATOM   2180 C  CG  . LEU A 1 300 ? 38.60900 -8.26000  37.25400 1.000 24.89586 ? 294 LEU A CG  1 
ATOM   2181 C  CD1 . LEU A 1 300 ? 39.72500 -7.23800  37.01600 1.000 24.04141 ? 294 LEU A CD1 1 
ATOM   2182 C  CD2 . LEU A 1 300 ? 38.95300 -9.15000  38.43500 1.000 21.59046 ? 294 LEU A CD2 1 
ATOM   2183 N  N   . ILE A 1 301 ? 34.02500 -7.28100  37.25300 1.000 20.41465 ? 295 ILE A N   1 
ATOM   2184 C  CA  . ILE A 1 301 ? 32.74900 -6.79700  37.77500 1.000 22.43675 ? 295 ILE A CA  1 
ATOM   2185 C  C   . ILE A 1 301 ? 31.91300 -7.97100  38.25300 1.000 22.72557 ? 295 ILE A C   1 
ATOM   2186 O  O   . ILE A 1 301 ? 31.39500 -7.95900  39.37500 1.000 21.64662 ? 295 ILE A O   1 
ATOM   2187 C  CB  . ILE A 1 301 ? 31.99300 -5.95400  36.73500 1.000 24.02204 ? 295 ILE A CB  1 
ATOM   2188 C  CG1 . ILE A 1 301 ? 32.68600 -4.60100  36.54300 1.000 23.20396 ? 295 ILE A CG1 1 
ATOM   2189 C  CG2 . ILE A 1 301 ? 30.52000 -5.75600  37.17100 1.000 22.81386 ? 295 ILE A CG2 1 
ATOM   2190 C  CD1 . ILE A 1 301 ? 32.06300 -3.76700  35.41100 1.000 26.76925 ? 295 ILE A CD1 1 
ATOM   2191 N  N   . ALA A 1 302 ? 31.80300 -9.02300  37.42200 1.000 21.43139 ? 296 ALA A N   1 
ATOM   2192 C  CA  . ALA A 1 302 ? 31.02500 -10.20100 37.81500 1.000 21.92772 ? 296 ALA A CA  1 
ATOM   2193 C  C   . ALA A 1 302 ? 31.57200 -10.83600 39.08700 1.000 19.32857 ? 296 ALA A C   1 
ATOM   2194 O  O   . ALA A 1 302 ? 30.80200 -11.24700 39.96700 1.000 21.74892 ? 296 ALA A O   1 
ATOM   2195 C  CB  . ALA A 1 302 ? 31.00000 -11.24100 36.68700 1.000 15.92662 ? 296 ALA A CB  1 
ATOM   2196 N  N   . ILE A 1 303 ? 32.89900 -10.90700 39.22000 1.000 18.16605 ? 297 ILE A N   1 
ATOM   2197 C  CA  . ILE A 1 303 ? 33.47000 -11.48000 40.44400 1.000 21.00340 ? 297 ILE A CA  1 
ATOM   2198 C  C   . ILE A 1 303 ? 33.10900 -10.62900 41.66200 1.000 21.02037 ? 297 ILE A C   1 
ATOM   2199 O  O   . ILE A 1 303 ? 32.71600 -11.15700 42.71600 1.000 17.85726 ? 297 ILE A O   1 
ATOM   2200 C  CB  . ILE A 1 303 ? 34.99300 -11.65400 40.30600 1.000 19.09845 ? 297 ILE A CB  1 
ATOM   2201 C  CG1 . ILE A 1 303 ? 35.29200 -12.85200 39.39500 1.000 17.86843 ? 297 ILE A CG1 1 
ATOM   2202 C  CG2 . ILE A 1 303 ? 35.62200 -11.82500 41.70900 1.000 16.98665 ? 297 ILE A CG2 1 
ATOM   2203 C  CD1 . ILE A 1 303 ? 36.73500 -12.92500 38.87400 1.000 20.01494 ? 297 ILE A CD1 1 
ATOM   2204 N  N   . ALA A 1 304 ? 33.21800 -9.30100  41.53700 1.000 21.03026 ? 298 ALA A N   1 
ATOM   2205 C  CA  . ALA A 1 304 ? 32.89300 -8.42800  42.66300 1.000 18.64125 ? 298 ALA A CA  1 
ATOM   2206 C  C   . ALA A 1 304 ? 31.42900 -8.58000  43.06700 1.000 23.68968 ? 298 ALA A C   1 
ATOM   2207 O  O   . ALA A 1 304 ? 31.10900 -8.66400  44.26400 1.000 22.49762 ? 298 ALA A O   1 
ATOM   2208 C  CB  . ALA A 1 304 ? 33.21300 -6.97800  42.31000 1.000 22.15137 ? 298 ALA A CB  1 
ATOM   2209 N  N   . ARG A 1 305 ? 30.52800 -8.65600  42.07700 1.000 20.93361 ? 299 ARG A N   1 
ATOM   2210 C  CA  . ARG A 1 305 ? 29.11300 -8.86200  42.36600 1.000 20.00374 ? 299 ARG A CA  1 
ATOM   2211 C  C   . ARG A 1 305 ? 28.88200 -10.18500 43.09400 1.000 24.91317 ? 299 ARG A C   1 
ATOM   2212 O  O   . ARG A 1 305 ? 28.04700 -10.26900 44.00100 1.000 24.10557 ? 299 ARG A O   1 
ATOM   2213 C  CB  . ARG A 1 305 ? 28.30600 -8.83400  41.06600 1.000 24.08256 ? 299 ARG A CB  1 
ATOM   2214 C  CG  . ARG A 1 305 ? 28.32700 -7.49400  40.33200 1.000 20.47641 ? 299 ARG A CG  1 
ATOM   2215 C  CD  . ARG A 1 305 ? 27.78800 -6.37800  41.22800 1.000 24.05685 ? 299 ARG A CD  1 
ATOM   2216 N  NE  . ARG A 1 305 ? 26.35600 -6.49500  41.49700 1.000 29.78233 ? 299 ARG A NE  1 
ATOM   2217 C  CZ  . ARG A 1 305 ? 25.65300 -5.63000  42.22700 1.000 40.22591 ? 299 ARG A CZ  1 
ATOM   2218 N  NH1 . ARG A 1 305 ? 26.22200 -4.58100  42.80200 1.000 36.59407 ? 299 ARG A NH1 1 
ATOM   2219 N  NH2 . ARG A 1 305 ? 24.34100 -5.80600  42.36500 1.000 34.83780 ? 299 ARG A NH2 1 
ATOM   2220 N  N   . SER A 1 306 ? 29.61700 -11.22700 42.71200 1.000 22.68567 ? 300 SER A N   1 
ATOM   2221 C  CA  . SER A 1 306 ? 29.39400 -12.54700 43.29500 1.000 21.74277 ? 300 SER A CA  1 
ATOM   2222 C  C   . SER A 1 306 ? 29.63000 -12.56700 44.80900 1.000 23.54546 ? 300 SER A C   1 
ATOM   2223 O  O   . SER A 1 306 ? 29.05300 -13.40900 45.50800 1.000 23.66423 ? 300 SER A O   1 
ATOM   2224 C  CB  . SER A 1 306 ? 30.28700 -13.56800 42.58100 1.000 17.62103 ? 300 SER A CB  1 
ATOM   2225 O  OG  . SER A 1 306 ? 31.60400 -13.58700 43.12300 1.000 20.34265 ? 300 SER A OG  1 
ATOM   2226 N  N   . VAL A 1 307 ? 30.45000 -11.65900 45.34600 1.000 21.52530 ? 301 VAL A N   1 
ATOM   2227 C  CA  . VAL A 1 307 ? 30.67300 -11.60300 46.79700 1.000 21.40964 ? 301 VAL A CA  1 
ATOM   2228 C  C   . VAL A 1 307 ? 29.89800 -10.46300 47.44700 1.000 22.62948 ? 301 VAL A C   1 
ATOM   2229 O  O   . VAL A 1 307 ? 30.15500 -10.11900 48.60500 1.000 29.98204 ? 301 VAL A O   1 
ATOM   2230 C  CB  . VAL A 1 307 ? 32.16700 -11.52300 47.15300 1.000 26.68392 ? 301 VAL A CB  1 
ATOM   2231 C  CG1 . VAL A 1 307 ? 32.86600 -12.81000 46.75200 1.000 23.21275 ? 301 VAL A CG1 1 
ATOM   2232 C  CG2 . VAL A 1 307 ? 32.86500 -10.30200 46.47700 1.000 22.09457 ? 301 VAL A CG2 1 
ATOM   2233 N  N   . GLY A 1 308 ? 28.94200 -9.88400  46.73800 1.000 24.50120 ? 302 GLY A N   1 
ATOM   2234 C  CA  . GLY A 1 308 ? 28.14400 -8.83500  47.32800 1.000 28.86546 ? 302 GLY A CA  1 
ATOM   2235 C  C   . GLY A 1 308 ? 28.79800 -7.47900  47.34700 1.000 30.88249 ? 302 GLY A C   1 
ATOM   2236 O  O   . GLY A 1 308 ? 28.37600 -6.62400  48.12300 1.000 31.39661 ? 302 GLY A O   1 
ATOM   2237 N  N   . LEU A 1 309 ? 29.79700 -7.24900  46.50400 1.000 28.48028 ? 303 LEU A N   1 
ATOM   2238 C  CA  . LEU A 1 309 ? 30.51500 -5.98300  46.41000 1.000 29.00808 ? 303 LEU A CA  1 
ATOM   2239 C  C   . LEU A 1 309 ? 30.11400 -5.23100  45.14500 1.000 31.89939 ? 303 LEU A C   1 
ATOM   2240 O  O   . LEU A 1 309 ? 29.41600 -5.74900  44.26400 1.000 29.87456 ? 303 LEU A O   1 
ATOM   2241 C  CB  . LEU A 1 309 ? 32.02900 -6.22100  46.42400 1.000 24.91679 ? 303 LEU A CB  1 
ATOM   2242 C  CG  . LEU A 1 309 ? 32.53700 -6.77300  47.76100 1.000 26.77529 ? 303 LEU A CG  1 
ATOM   2243 C  CD1 . LEU A 1 309 ? 34.02300 -7.12900  47.68800 1.000 23.82027 ? 303 LEU A CD1 1 
ATOM   2244 C  CD2 . LEU A 1 309 ? 32.24400 -5.77500  48.90100 1.000 25.33472 ? 303 LEU A CD2 1 
ATOM   2245 N  N   . GLU A 1 310 ? 30.56800 -3.98500  45.06500 1.000 31.13602 ? 304 GLU A N   1 
ATOM   2246 C  CA  . GLU A 1 310 ? 30.30500 -3.12300  43.92200 1.000 32.27813 ? 304 GLU A CA  1 
ATOM   2247 C  C   . GLU A 1 310 ? 31.61700 -2.82500  43.20900 1.000 29.19773 ? 304 GLU A C   1 
ATOM   2248 O  O   . GLU A 1 310 ? 32.67800 -2.77400  43.82800 1.000 28.42160 ? 304 GLU A O   1 
ATOM   2249 C  CB  . GLU A 1 310 ? 29.63800 -1.81100  44.35500 1.000 30.49963 ? 304 GLU A CB  1 
ATOM   2250 C  CG  . GLU A 1 310 ? 28.32700 -1.98900  45.11500 1.000 41.40578 ? 304 GLU A CG  1 
ATOM   2251 C  CD  . GLU A 1 310 ? 27.69300 -0.65500  45.50200 1.000 53.28001 ? 304 GLU A CD  1 
ATOM   2252 O  OE1 . GLU A 1 310 ? 28.44100 0.33600   45.65800 1.000 52.34276 ? 304 GLU A OE1 1 
ATOM   2253 O  OE2 . GLU A 1 310 ? 26.45200 -0.59100  45.64200 1.000 55.98489 ? 304 GLU A OE2 1 
ATOM   2254 N  N   . LEU A 1 311 ? 31.53200 -2.66100  41.89700 1.000 31.47466 ? 305 LEU A N   1 
ATOM   2255 C  CA  . LEU A 1 311 ? 32.67800 -2.34800  41.04900 1.000 27.69513 ? 305 LEU A CA  1 
ATOM   2256 C  C   . LEU A 1 311 ? 32.10800 -1.74600  39.77900 1.000 27.46173 ? 305 LEU A C   1 
ATOM   2257 O  O   . LEU A 1 311 ? 31.32700 -2.40300  39.08100 1.000 26.97593 ? 305 LEU A O   1 
ATOM   2258 C  CB  . LEU A 1 311 ? 33.50900 -3.59000  40.73100 1.000 25.93955 ? 305 LEU A CB  1 
ATOM   2259 C  CG  . LEU A 1 311 ? 34.94300 -3.40100  40.21200 1.000 29.42681 ? 305 LEU A CG  1 
ATOM   2260 C  CD1 . LEU A 1 311 ? 35.82600 -2.60100  41.20600 1.000 23.97386 ? 305 LEU A CD1 1 
ATOM   2261 C  CD2 . LEU A 1 311 ? 35.59500 -4.75700  39.88300 1.000 23.60875 ? 305 LEU A CD2 1 
ATOM   2262 N  N   . THR A 1 312 ? 32.46500 -0.50400  39.49500 1.000 30.64830 ? 306 THR A N   1 
ATOM   2263 C  CA  . THR A 1 312 ? 31.88800 0.22500   38.37800 1.000 29.62151 ? 306 THR A CA  1 
ATOM   2264 C  C   . THR A 1 312 ? 32.94000 0.44800   37.29900 1.000 26.98322 ? 306 THR A C   1 
ATOM   2265 O  O   . THR A 1 312 ? 34.13900 0.20500   37.49100 1.000 27.41038 ? 306 THR A O   1 
ATOM   2266 C  CB  . THR A 1 312 ? 31.30600 1.56600   38.85700 1.000 31.34179 ? 306 THR A CB  1 
ATOM   2267 O  OG1 . THR A 1 312 ? 32.36500 2.38400   39.36200 1.000 29.87061 ? 306 THR A OG1 1 
ATOM   2268 C  CG2 . THR A 1 312 ? 30.27300 1.33700   39.97500 1.000 31.72327 ? 306 THR A CG2 1 
ATOM   2269 N  N   . LEU A 1 313 ? 32.46700 0.90900   36.14300 1.000 26.38368 ? 307 LEU A N   1 
ATOM   2270 C  CA  . LEU A 1 313 ? 33.39200 1.32800   35.09400 1.000 28.32713 ? 307 LEU A CA  1 
ATOM   2271 C  C   . LEU A 1 313 ? 34.32200 2.42900   35.59100 1.000 28.18084 ? 307 LEU A C   1 
ATOM   2272 O  O   . LEU A 1 313 ? 35.51200 2.42900   35.26200 1.000 24.69223 ? 307 LEU A O   1 
ATOM   2273 C  CB  . LEU A 1 313 ? 32.62000 1.81500   33.87100 1.000 27.70608 ? 307 LEU A CB  1 
ATOM   2274 C  CG  . LEU A 1 313 ? 31.76500 0.79500   33.12000 1.000 31.18556 ? 307 LEU A CG  1 
ATOM   2275 C  CD1 . LEU A 1 313 ? 31.22600 1.40500   31.82400 1.000 26.12196 ? 307 LEU A CD1 1 
ATOM   2276 C  CD2 . LEU A 1 313 ? 32.56200 -0.49700  32.86900 1.000 24.47780 ? 307 LEU A CD2 1 
ATOM   2277 N  N   . ASP A 1 314 ? 33.79300 3.37900   36.38600 1.000 32.44942 ? 308 ASP A N   1 
ATOM   2278 C  CA  . ASP A 1 314 ? 34.62600 4.47000   36.90900 1.000 31.91819 ? 308 ASP A CA  1 
ATOM   2279 C  C   . ASP A 1 314 ? 35.75300 3.94300   37.78500 1.000 28.97919 ? 308 ASP A C   1 
ATOM   2280 O  O   . ASP A 1 314 ? 36.85500 4.50700   37.79100 1.000 31.35231 ? 308 ASP A O   1 
ATOM   2281 C  CB  . ASP A 1 314 ? 33.78700 5.47100   37.71000 1.000 37.97752 ? 308 ASP A CB  1 
ATOM   2282 C  CG  . ASP A 1 314 ? 32.83900 6.28400   36.84100 1.000 46.29572 ? 308 ASP A CG  1 
ATOM   2283 O  OD1 . ASP A 1 314 ? 33.06200 6.37100   35.60700 1.000 48.94635 ? 308 ASP A OD1 1 
ATOM   2284 O  OD2 . ASP A 1 314 ? 31.86500 6.84100   37.39700 1.000 50.30466 ? 308 ASP A OD2 1 
ATOM   2285 N  N   . ASP A 1 315 ? 35.49200 2.87200   38.54700 1.000 29.36424 ? 309 ASP A N   1 
ATOM   2286 C  CA  . ASP A 1 315 ? 36.55400 2.24600   39.32900 1.000 29.31588 ? 309 ASP A CA  1 
ATOM   2287 C  C   . ASP A 1 315 ? 37.71000 1.83000   38.43500 1.000 27.24999 ? 309 ASP A C   1 
ATOM   2288 O  O   . ASP A 1 315 ? 38.88200 2.01400   38.79100 1.000 32.75194 ? 309 ASP A O   1 
ATOM   2289 C  CB  . ASP A 1 315 ? 36.01200 1.02900   40.08500 1.000 28.29268 ? 309 ASP A CB  1 
ATOM   2290 C  CG  . ASP A 1 315 ? 35.06300 1.40100   41.19900 1.000 32.97891 ? 309 ASP A CG  1 
ATOM   2291 O  OD1 . ASP A 1 315 ? 35.29900 2.42000   41.88000 1.000 33.46226 ? 309 ASP A OD1 1 
ATOM   2292 O  OD2 . ASP A 1 315 ? 34.06200 0.67500   41.39200 1.000 29.68985 ? 309 ASP A OD2 1 
ATOM   2293 N  N   . PHE A 1 316 ? 37.40100 1.24900   37.27400 1.000 27.29330 ? 310 PHE A N   1 
ATOM   2294 C  CA  . PHE A 1 316 ? 38.45100 0.87200   36.33000 1.000 25.68296 ? 310 PHE A CA  1 
ATOM   2295 C  C   . PHE A 1 316 ? 39.18300 2.09800   35.79600 1.000 28.21252 ? 310 PHE A C   1 
ATOM   2296 O  O   . PHE A 1 316 ? 40.41100 2.08300   35.66300 1.000 29.41159 ? 310 PHE A O   1 
ATOM   2297 C  CB  . PHE A 1 316 ? 37.86300 0.06400   35.17000 1.000 26.69497 ? 310 PHE A CB  1 
ATOM   2298 C  CG  . PHE A 1 316 ? 37.58300 -1.36400  35.52200 1.000 28.46508 ? 310 PHE A CG  1 
ATOM   2299 C  CD1 . PHE A 1 316 ? 36.39300 -1.70700  36.13300 1.000 27.50673 ? 310 PHE A CD1 1 
ATOM   2300 C  CD2 . PHE A 1 316 ? 38.52400 -2.35700  35.27200 1.000 28.71139 ? 310 PHE A CD2 1 
ATOM   2301 C  CE1 . PHE A 1 316 ? 36.13000 -3.02600  36.47600 1.000 29.27275 ? 310 PHE A CE1 1 
ATOM   2302 C  CE2 . PHE A 1 316 ? 38.26800 -3.67000  35.61000 1.000 26.65374 ? 310 PHE A CE2 1 
ATOM   2303 C  CZ  . PHE A 1 316 ? 37.06600 -4.00200  36.20500 1.000 24.81076 ? 310 PHE A CZ  1 
ATOM   2304 N  N   . GLN A 1 317 ? 38.45100 3.16500   35.47100 1.000 27.22765 ? 311 GLN A N   1 
ATOM   2305 C  CA  . GLN A 1 317 ? 39.11600 4.36600   34.97100 1.000 29.85298 ? 311 GLN A CA  1 
ATOM   2306 C  C   . GLN A 1 317 ? 40.06100 4.95300   36.01800 1.000 32.36052 ? 311 GLN A C   1 
ATOM   2307 O  O   . GLN A 1 317 ? 41.15900 5.41500   35.68300 1.000 32.38825 ? 311 GLN A O   1 
ATOM   2308 C  CB  . GLN A 1 317 ? 38.08200 5.40600   34.52800 1.000 31.27109 ? 311 GLN A CB  1 
ATOM   2309 C  CG  . GLN A 1 317 ? 38.68100 6.59800   33.77000 1.000 34.66208 ? 311 GLN A CG  1 
ATOM   2310 C  CD  . GLN A 1 317 ? 39.34300 6.17700   32.47600 1.000 31.45609 ? 311 GLN A CD  1 
ATOM   2311 O  OE1 . GLN A 1 317 ? 38.69000 5.63500   31.59600 1.000 31.89602 ? 311 GLN A OE1 1 
ATOM   2312 N  NE2 . GLN A 1 317 ? 40.64500 6.42000   32.35700 1.000 29.33056 ? 311 GLN A NE2 1 
ATOM   2313 N  N   . LYS A 1 318 ? 39.65700 4.94700   37.29200 1.000 32.53895 ? 312 LYS A N   1 
ATOM   2314 C  CA  . LYS A 1 318 ? 40.52200 5.50300   38.33300 1.000 31.51604 ? 312 LYS A CA  1 
ATOM   2315 C  C   . LYS A 1 318 ? 41.79000 4.68200   38.50400 1.000 33.85583 ? 312 LYS A C   1 
ATOM   2316 O  O   . LYS A 1 318 ? 42.88800 5.24000   38.62200 1.000 34.08664 ? 312 LYS A O   1 
ATOM   2317 C  CB  . LYS A 1 318 ? 39.78200 5.59800   39.66300 1.000 38.57896 ? 312 LYS A CB  1 
ATOM   2318 C  CG  . LYS A 1 318 ? 38.71100 6.66700   39.69500 1.000 40.70473 ? 312 LYS A CG  1 
ATOM   2319 C  CD  . LYS A 1 318 ? 37.73300 6.42700   40.84500 1.000 39.07882 ? 312 LYS A CD  1 
ATOM   2320 C  CE  . LYS A 1 318 ? 36.62500 7.47300   40.83700 1.000 49.29404 ? 312 LYS A CE  1 
ATOM   2321 N  NZ  . LYS A 1 318 ? 36.22800 7.87200   42.22200 1.000 56.87108 ? 312 LYS A NZ  1 
ATOM   2322 N  N   . VAL A 1 319 ? 41.66900 3.35500   38.51800 1.000 29.69588 ? 313 VAL A N   1 
ATOM   2323 C  CA  . VAL A 1 319 ? 42.87000 2.53500   38.59800 1.000 32.35487 ? 313 VAL A CA  1 
ATOM   2324 C  C   . VAL A 1 319 ? 43.71300 2.71800   37.35000 1.000 34.54810 ? 313 VAL A C   1 
ATOM   2325 O  O   . VAL A 1 319 ? 44.94400 2.80500   37.42700 1.000 34.23914 ? 313 VAL A O   1 
ATOM   2326 C  CB  . VAL A 1 319 ? 42.51600 1.05700   38.82200 1.000 31.15115 ? 313 VAL A CB  1 
ATOM   2327 C  CG1 . VAL A 1 319 ? 43.78600 0.24500   38.96100 1.000 25.90551 ? 313 VAL A CG1 1 
ATOM   2328 C  CG2 . VAL A 1 319 ? 41.62400 0.91500   40.05200 1.000 29.79271 ? 313 VAL A CG2 1 
ATOM   2329 N  N   . SER A 1 320 ? 43.06800 2.76700   36.17500 1.000 32.14822 ? 314 SER A N   1 
ATOM   2330 C  CA  . SER A 1 320 ? 43.81700 2.98100   34.93800 1.000 33.69343 ? 314 SER A CA  1 
ATOM   2331 C  C   . SER A 1 320 ? 44.63900 4.26700   35.01100 1.000 35.04551 ? 314 SER A C   1 
ATOM   2332 O  O   . SER A 1 320 ? 45.83500 4.27800   34.69100 1.000 33.95364 ? 314 SER A O   1 
ATOM   2333 C  CB  . SER A 1 320 ? 42.86900 3.02900   33.74500 1.000 30.85508 ? 314 SER A CB  1 
ATOM   2334 O  OG  . SER A 1 320 ? 43.61500 3.13100   32.54700 1.000 30.80629 ? 314 SER A OG  1 
ATOM   2335 N  N   . ASP A 1 321 ? 44.00200 5.36200   35.43800 1.000 34.42391 ? 315 ASP A N   1 
ATOM   2336 C  CA  . ASP A 1 321 ? 44.70400 6.62900   35.61700 1.000 38.03293 ? 315 ASP A CA  1 
ATOM   2337 C  C   . ASP A 1 321 ? 45.85900 6.50100   36.60000 1.000 40.11579 ? 315 ASP A C   1 
ATOM   2338 O  O   . ASP A 1 321 ? 46.88500 7.17300   36.44100 1.000 45.66354 ? 315 ASP A O   1 
ATOM   2339 C  CB  . ASP A 1 321 ? 43.73700 7.70200   36.11000 1.000 30.11942 ? 315 ASP A CB  1 
ATOM   2340 C  CG  . ASP A 1 321 ? 42.71100 8.09600   35.06000 1.000 37.69615 ? 315 ASP A CG  1 
ATOM   2341 O  OD1 . ASP A 1 321 ? 42.90200 7.78200   33.86600 1.000 32.28856 ? 315 ASP A OD1 1 
ATOM   2342 O  OD2 . ASP A 1 321 ? 41.70600 8.73400   35.43700 1.000 36.85478 ? 315 ASP A OD2 1 
ATOM   2343 N  N   . ALA A 1 322 ? 45.72100 5.63900   37.61000 1.000 40.08685 ? 316 ALA A N   1 
ATOM   2344 C  CA  . ALA A 1 322 ? 46.69300 5.56700   38.69300 1.000 38.57000 ? 316 ALA A CA  1 
ATOM   2345 C  C   . ALA A 1 322 ? 47.85500 4.62500   38.41200 1.000 43.59618 ? 316 ALA A C   1 
ATOM   2346 O  O   . ALA A 1 322 ? 48.85500 4.67800   39.13300 1.000 40.76382 ? 316 ALA A O   1 
ATOM   2347 C  CB  . ALA A 1 322 ? 46.00300 5.12600   39.98700 1.000 38.27379 ? 316 ALA A CB  1 
ATOM   2348 N  N   . VAL A 1 323 ? 47.74200 3.74400   37.41400 1.000 41.31692 ? 317 VAL A N   1 
ATOM   2349 C  CA  . VAL A 1 323 ? 48.68900 2.65600   37.21600 1.000 39.51180 ? 317 VAL A CA  1 
ATOM   2350 C  C   . VAL A 1 323 ? 49.21900 2.69000   35.79000 1.000 42.85296 ? 317 VAL A C   1 
ATOM   2351 O  O   . VAL A 1 323 ? 48.43600 2.59700   34.83800 1.000 40.51586 ? 317 VAL A O   1 
ATOM   2352 C  CB  . VAL A 1 323 ? 48.07200 1.27600   37.50500 1.000 36.30173 ? 317 VAL A CB  1 
ATOM   2353 C  CG1 . VAL A 1 323 ? 49.12700 0.17600   37.29800 1.000 33.48431 ? 317 VAL A CG1 1 
ATOM   2354 C  CG2 . VAL A 1 323 ? 47.47300 1.23600   38.90800 1.000 37.40831 ? 317 VAL A CG2 1 
ATOM   2355 N  N   . PRO A 1 324 ? 50.53100 2.77200   35.58900 1.000 47.28406 ? 318 PRO A N   1 
ATOM   2356 C  CA  . PRO A 1 324 ? 51.08500 2.76700   34.23300 1.000 44.52607 ? 318 PRO A CA  1 
ATOM   2357 C  C   . PRO A 1 324 ? 51.16800 1.36600   33.64300 1.000 44.62662 ? 318 PRO A C   1 
ATOM   2358 O  O   . PRO A 1 324 ? 51.24100 0.35600   34.35000 1.000 45.29601 ? 318 PRO A O   1 
ATOM   2359 C  CB  . PRO A 1 324 ? 52.48600 3.35300   34.42900 1.000 47.05113 ? 318 PRO A CB  1 
ATOM   2360 C  CG  . PRO A 1 324 ? 52.84900 2.93400   35.81700 1.000 52.88277 ? 318 PRO A CG  1 
ATOM   2361 C  CD  . PRO A 1 324 ? 51.56300 3.03000   36.60900 1.000 50.07041 ? 318 PRO A CD  1 
ATOM   2362 N  N   . PHE A 1 325 ? 51.16400 1.33200   32.31100 1.000 43.63712 ? 319 PHE A N   1 
ATOM   2363 C  CA  . PHE A 1 325 ? 51.39400 0.11100   31.54600 1.000 41.20247 ? 319 PHE A CA  1 
ATOM   2364 C  C   . PHE A 1 325 ? 52.89800 -0.12400  31.44900 1.000 45.01550 ? 319 PHE A C   1 
ATOM   2365 O  O   . PHE A 1 325 ? 53.62000 0.69200   30.87300 1.000 45.35137 ? 319 PHE A O   1 
ATOM   2366 C  CB  . PHE A 1 325 ? 50.75000 0.23900   30.16200 1.000 43.14009 ? 319 PHE A CB  1 
ATOM   2367 C  CG  . PHE A 1 325 ? 51.05500 -0.90300  29.21800 1.000 47.11706 ? 319 PHE A CG  1 
ATOM   2368 C  CD1 . PHE A 1 325 ? 51.08400 -2.21500  29.66700 1.000 42.72166 ? 319 PHE A CD1 1 
ATOM   2369 C  CD2 . PHE A 1 325 ? 51.27900 -0.66200  27.86300 1.000 52.11955 ? 319 PHE A CD2 1 
ATOM   2370 C  CE1 . PHE A 1 325 ? 51.35400 -3.26600  28.78700 1.000 45.52143 ? 319 PHE A CE1 1 
ATOM   2371 C  CE2 . PHE A 1 325 ? 51.55400 -1.70800  26.97900 1.000 46.69852 ? 319 PHE A CE2 1 
ATOM   2372 C  CZ  . PHE A 1 325 ? 51.58900 -3.01000  27.44200 1.000 45.95724 ? 319 PHE A CZ  1 
ATOM   2373 N  N   . LEU A 1 326 ? 53.37000 -1.23700  32.01700 1.000 45.52091 ? 320 LEU A N   1 
ATOM   2374 C  CA  . LEU A 1 326 ? 54.79600 -1.48100  32.18000 1.000 46.16463 ? 320 LEU A CA  1 
ATOM   2375 C  C   . LEU A 1 326 ? 55.33100 -2.70800  31.46000 1.000 54.69101 ? 320 LEU A C   1 
ATOM   2376 O  O   . LEU A 1 326 ? 56.54700 -2.78500  31.25200 1.000 55.98976 ? 320 LEU A O   1 
ATOM   2377 C  CB  . LEU A 1 326 ? 55.14600 -1.62800  33.67000 1.000 51.23155 ? 320 LEU A CB  1 
ATOM   2378 C  CG  . LEU A 1 326 ? 54.69700 -0.50200  34.60400 1.000 55.50137 ? 320 LEU A CG  1 
ATOM   2379 C  CD1 . LEU A 1 326 ? 55.14600 -0.77100  36.04500 1.000 52.14920 ? 320 LEU A CD1 1 
ATOM   2380 C  CD2 . LEU A 1 326 ? 55.24100 0.82900   34.11100 1.000 54.92602 ? 320 LEU A CD2 1 
ATOM   2381 N  N   . ALA A 1 327 ? 54.48200 -3.66900  31.09200 1.000 53.32101 ? 321 ALA A N   1 
ATOM   2382 C  CA  . ALA A 1 327 ? 54.93400 -4.98100  30.63900 1.000 53.25453 ? 321 ALA A CA  1 
ATOM   2383 C  C   . ALA A 1 327 ? 54.96800 -5.04900  29.11900 1.000 50.89063 ? 321 ALA A C   1 
ATOM   2384 O  O   . ALA A 1 327 ? 53.98400 -4.71200  28.45000 1.000 47.39176 ? 321 ALA A O   1 
ATOM   2385 C  CB  . ALA A 1 327 ? 54.04100 -6.09600  31.18900 1.000 46.78490 ? 321 ALA A CB  1 
ATOM   2386 N  N   . ASP A 1 328 ? 56.10100 -5.50400  28.58400 1.000 56.23210 ? 322 ASP A N   1 
ATOM   2387 C  CA  . ASP A 1 328 ? 56.30100 -5.65700  27.14100 1.000 54.58133 ? 322 ASP A CA  1 
ATOM   2388 C  C   . ASP A 1 328 ? 55.79200 -7.03000  26.69500 1.000 57.70799 ? 322 ASP A C   1 
ATOM   2389 O  O   . ASP A 1 328 ? 56.55300 -7.94100  26.35400 1.000 55.28822 ? 322 ASP A O   1 
ATOM   2390 C  CB  . ASP A 1 328 ? 57.77200 -5.46200  26.79400 1.000 59.19321 ? 322 ASP A CB  1 
ATOM   2391 C  CG  . ASP A 1 328 ? 57.98000 -5.03300  25.35800 1.000 63.57190 ? 322 ASP A CG  1 
ATOM   2392 O  OD1 . ASP A 1 328 ? 56.96600 -4.84600  24.64700 1.000 58.47902 ? 322 ASP A OD1 1 
ATOM   2393 O  OD2 . ASP A 1 328 ? 59.15200 -4.89400  24.94200 1.000 68.21993 ? 322 ASP A OD2 1 
ATOM   2394 N  N   . LEU A 1 329 ? 54.46500 -7.16500  26.69600 1.000 50.09990 ? 323 LEU A N   1 
ATOM   2395 C  CA  . LEU A 1 329 ? 53.80900 -8.44800  26.47600 1.000 54.61971 ? 323 LEU A CA  1 
ATOM   2396 C  C   . LEU A 1 329 ? 52.81200 -8.35600  25.33000 1.000 50.30792 ? 323 LEU A C   1 
ATOM   2397 O  O   . LEU A 1 329 ? 52.09800 -7.35600  25.18900 1.000 47.24671 ? 323 LEU A O   1 
ATOM   2398 C  CB  . LEU A 1 329 ? 53.08700 -8.92200  27.74700 1.000 54.07875 ? 323 LEU A CB  1 
ATOM   2399 C  CG  . LEU A 1 329 ? 53.99000 -9.30500  28.92100 1.000 50.65037 ? 323 LEU A CG  1 
ATOM   2400 C  CD1 . LEU A 1 329 ? 53.17900 -9.50100  30.19200 1.000 46.76280 ? 323 LEU A CD1 1 
ATOM   2401 C  CD2 . LEU A 1 329 ? 54.81700 -10.54300 28.59200 1.000 50.99524 ? 323 LEU A CD2 1 
ATOM   2402 N  N   . LYS A 1 330 ? 52.77100 -9.41400  24.52000 1.000 50.14060 ? 324 LYS A N   1 
ATOM   2403 C  CA  . LYS A 1 330 ? 51.77300 -9.59400  23.47500 1.000 50.12601 ? 324 LYS A CA  1 
ATOM   2404 C  C   . LYS A 1 330 ? 50.37900 -9.49400  24.09000 1.000 50.69478 ? 324 LYS A C   1 
ATOM   2405 O  O   . LYS A 1 330 ? 50.18400 -9.90000  25.24300 1.000 52.90470 ? 324 LYS A O   1 
ATOM   2406 C  CB  . LYS A 1 330 ? 51.96900 -10.94400 22.77800 1.000 50.33261 ? 324 LYS A CB  1 
ATOM   2407 C  CG  . LYS A 1 330 ? 52.84800 -10.88200 21.53600 1.000 58.93666 ? 324 LYS A CG  1 
ATOM   2408 C  CD  . LYS A 1 330 ? 53.43800 -12.25300 21.21000 1.000 68.96577 ? 324 LYS A CD  1 
ATOM   2409 C  CE  . LYS A 1 330 ? 53.36500 -12.57700 19.71500 1.000 76.03162 ? 324 LYS A CE  1 
ATOM   2410 N  NZ  . LYS A 1 330 ? 51.96600 -12.76700 19.22300 1.000 70.19101 ? 324 LYS A NZ  1 
ATOM   2411 N  N   . PRO A 1 331 ? 49.34500 -8.97900  23.37000 1.000 51.29327 ? 325 PRO A N   1 
ATOM   2412 C  CA  . PRO A 1 331 ? 49.48800 -8.49800  21.98200 1.000 50.92378 ? 325 PRO A CA  1 
ATOM   2413 C  C   . PRO A 1 331 ? 50.11800 -7.10900  21.77400 1.000 49.44851 ? 325 PRO A C   1 
ATOM   2414 O  O   . PRO A 1 331 ? 50.64800 -6.88100  20.71800 1.000 50.90987 ? 325 PRO A O   1 
ATOM   2415 C  CB  . PRO A 1 331 ? 48.03200 -8.48400  21.48700 1.000 51.36699 ? 325 PRO A CB  1 
ATOM   2416 C  CG  . PRO A 1 331 ? 47.22000 -8.14000  22.69700 1.000 51.71989 ? 325 PRO A CG  1 
ATOM   2417 C  CD  . PRO A 1 331 ? 47.92200 -8.89700  23.79600 1.000 46.31490 ? 325 PRO A CD  1 
ATOM   2418 N  N   . SER A 1 332 ? 50.05300 -6.23900  22.77900 1.000 47.82495 ? 326 SER A N   1 
ATOM   2419 C  CA  . SER A 1 332 ? 50.62900 -4.87400  22.67600 1.000 50.70941 ? 326 SER A CA  1 
ATOM   2420 C  C   . SER A 1 332 ? 52.14200 -4.93300  22.46100 1.000 52.63576 ? 326 SER A C   1 
ATOM   2421 O  O   . SER A 1 332 ? 52.64300 -4.12100  21.67700 1.000 54.17895 ? 326 SER A O   1 
ATOM   2422 C  CB  . SER A 1 332 ? 50.29700 -4.07100  23.89100 1.000 50.35122 ? 326 SER A CB  1 
ATOM   2423 O  OG  . SER A 1 332 ? 48.93200 -3.70900  23.86800 1.000 56.79609 ? 326 SER A OG  1 
ATOM   2424 N  N   . GLY A 1 333 ? 52.82600 -5.86000  23.12700 1.000 56.05433 ? 327 GLY A N   1 
ATOM   2425 C  CA  . GLY A 1 333 ? 54.29600 -5.95800  23.04900 1.000 56.87386 ? 327 GLY A CA  1 
ATOM   2426 C  C   . GLY A 1 333 ? 54.81800 -7.21300  22.38300 1.000 51.34326 ? 327 GLY A C   1 
ATOM   2427 O  O   . GLY A 1 333 ? 54.12000 -7.75400  21.52200 1.000 48.37032 ? 327 GLY A O   1 
ATOM   2428 N  N   . LYS A 1 334 ? 56.01300 -7.65500  22.78400 1.000 58.57559 ? 328 LYS A N   1 
ATOM   2429 C  CA  . LYS A 1 334 ? 56.67600 -8.78200  22.07600 1.000 58.01192 ? 328 LYS A CA  1 
ATOM   2430 C  C   . LYS A 1 334 ? 56.79700 -10.06800 22.90000 1.000 52.60615 ? 328 LYS A C   1 
ATOM   2431 O  O   . LYS A 1 334 ? 56.93100 -11.12200 22.27600 1.000 58.46317 ? 328 LYS A O   1 
ATOM   2432 C  CB  . LYS A 1 334 ? 58.08100 -8.34900  21.64700 1.000 63.51649 ? 328 LYS A CB  1 
ATOM   2433 C  CG  . LYS A 1 334 ? 58.85300 -7.51000  22.65300 1.000 65.15453 ? 328 LYS A CG  1 
ATOM   2434 C  CD  . LYS A 1 334 ? 60.28700 -7.26100  22.24000 1.000 71.13495 ? 328 LYS A CD  1 
ATOM   2435 C  CE  . LYS A 1 334 ? 60.45400 -5.99700  21.42600 1.000 70.30436 ? 328 LYS A CE  1 
ATOM   2436 N  NZ  . LYS A 1 334 ? 59.97000 -4.80300  22.15800 1.000 66.58839 ? 328 LYS A NZ  1 
ATOM   2437 N  N   . TYR A 1 335 ? 56.74900 -10.00400 24.22900 1.000 54.47047 ? 329 TYR A N   1 
ATOM   2438 C  CA  . TYR A 1 335 ? 57.01200 -11.22900 25.03500 1.000 54.82652 ? 329 TYR A CA  1 
ATOM   2439 C  C   . TYR A 1 335 ? 55.72100 -11.97600 25.40900 1.000 57.01976 ? 329 TYR A C   1 
ATOM   2440 O  O   . TYR A 1 335 ? 54.62200 -11.45600 25.17300 1.000 51.18209 ? 329 TYR A O   1 
ATOM   2441 C  CB  . TYR A 1 335 ? 57.84400 -10.88300 26.27300 1.000 57.36858 ? 329 TYR A CB  1 
ATOM   2442 C  CG  . TYR A 1 335 ? 59.21300 -10.31400 26.00000 1.000 60.79446 ? 329 TYR A CG  1 
ATOM   2443 C  CD1 . TYR A 1 335 ? 60.29400 -11.14200 25.75600 1.000 57.79919 ? 329 TYR A CD1 1 
ATOM   2444 C  CD2 . TYR A 1 335 ? 59.43600 -8.94800  26.00700 1.000 58.61982 ? 329 TYR A CD2 1 
ATOM   2445 C  CE1 . TYR A 1 335 ? 61.55700 -10.62600 25.51800 1.000 66.17257 ? 329 TYR A CE1 1 
ATOM   2446 C  CE2 . TYR A 1 335 ? 60.69000 -8.41300  25.77300 1.000 61.61568 ? 329 TYR A CE2 1 
ATOM   2447 C  CZ  . TYR A 1 335 ? 61.75600 -9.25700  25.52600 1.000 68.78468 ? 329 TYR A CZ  1 
ATOM   2448 O  OH  . TYR A 1 335 ? 62.99500 -8.74000  25.29100 1.000 72.37416 ? 329 TYR A OH  1 
ATOM   2449 N  N   . VAL A 1 336 ? 55.86500 -13.17500 25.97800 1.000 51.69229 ? 330 VAL A N   1 
ATOM   2450 C  CA  . VAL A 1 336 ? 54.68900 -14.01400 26.35800 1.000 54.01109 ? 330 VAL A CA  1 
ATOM   2451 C  C   . VAL A 1 336 ? 54.77300 -14.36400 27.85000 1.000 50.40913 ? 330 VAL A C   1 
ATOM   2452 O  O   . VAL A 1 336 ? 55.74500 -13.95700 28.50200 1.000 47.78815 ? 330 VAL A O   1 
ATOM   2453 C  CB  . VAL A 1 336 ? 54.57900 -15.28400 25.48900 1.000 50.77594 ? 330 VAL A CB  1 
ATOM   2454 C  CG1 . VAL A 1 336 ? 54.18000 -14.96900 24.05700 1.000 52.36367 ? 330 VAL A CG1 1 
ATOM   2455 C  CG2 . VAL A 1 336 ? 55.83200 -16.14000 25.53200 1.000 50.68872 ? 330 VAL A CG2 1 
ATOM   2456 N  N   . MET A 1 337 ? 53.77300 -15.08100 28.36400 1.000 46.68270 ? 331 MET A N   1 
ATOM   2457 C  CA  . MET A 1 337 ? 53.75500 -15.43400 29.78500 1.000 49.66598 ? 331 MET A CA  1 
ATOM   2458 C  C   . MET A 1 337 ? 54.95300 -16.28700 30.19900 1.000 46.43746 ? 331 MET A C   1 
ATOM   2459 O  O   . MET A 1 337 ? 55.40600 -16.19600 31.34700 1.000 42.76371 ? 331 MET A O   1 
ATOM   2460 C  CB  . MET A 1 337 ? 52.44900 -16.15900 30.14400 1.000 41.32140 ? 331 MET A CB  1 
ATOM   2461 C  CG  . MET A 1 337 ? 52.22100 -16.32300 31.65400 1.000 41.80690 ? 331 MET A CG  1 
ATOM   2462 S  SD  . MET A 1 337 ? 52.44100 -14.82900 32.66100 1.000 51.28036 ? 331 MET A SD  1 
ATOM   2463 C  CE  . MET A 1 337 ? 51.45900 -13.69200 31.71700 1.000 48.76436 ? 331 MET A CE  1 
ATOM   2464 N  N   . GLU A 1 338 ? 55.46800 -17.13100 29.30100 1.000 49.43563 ? 332 GLU A N   1 
ATOM   2465 C  CA  . GLU A 1 338 ? 56.63700 -17.93100 29.65500 1.000 51.13435 ? 332 GLU A CA  1 
ATOM   2466 C  C   . GLU A 1 338 ? 57.85600 -17.05700 29.94400 1.000 49.79812 ? 332 GLU A C   1 
ATOM   2467 O  O   . GLU A 1 338 ? 58.70600 -17.42500 30.76600 1.000 50.44368 ? 332 GLU A O   1 
ATOM   2468 C  CB  . GLU A 1 338 ? 56.95100 -18.93200 28.54600 1.000 54.38500 ? 332 GLU A CB  1 
ATOM   2469 C  CG  . GLU A 1 338 ? 57.57000 -20.21800 29.06700 1.000 59.43092 ? 332 GLU A CG  1 
ATOM   2470 C  CD  . GLU A 1 338 ? 57.46700 -21.36500 28.07600 1.000 70.97270 ? 332 GLU A CD  1 
ATOM   2471 O  OE1 . GLU A 1 338 ? 56.34300 -21.88600 27.85200 1.000 67.74555 ? 332 GLU A OE1 1 
ATOM   2472 O  OE2 . GLU A 1 338 ? 58.52200 -21.73900 27.51800 1.000 70.48955 ? 332 GLU A OE2 1 
ATOM   2473 N  N   . ASP A 1 339 ? 57.95500 -15.89500 29.29700 1.000 46.78638 ? 333 ASP A N   1 
ATOM   2474 C  CA  . ASP A 1 339 ? 59.09700 -15.01800 29.54100 1.000 50.88893 ? 333 ASP A CA  1 
ATOM   2475 C  C   . ASP A 1 339 ? 58.99100 -14.31100 30.89100 1.000 51.26139 ? 333 ASP A C   1 
ATOM   2476 O  O   . ASP A 1 339 ? 60.01700 -14.04300 31.53100 1.000 54.45074 ? 333 ASP A O   1 
ATOM   2477 C  CB  . ASP A 1 339 ? 59.22000 -14.01300 28.39700 1.000 50.65270 ? 333 ASP A CB  1 
ATOM   2478 C  CG  . ASP A 1 339 ? 59.17400 -14.68500 27.03300 1.000 50.06120 ? 333 ASP A CG  1 
ATOM   2479 O  OD1 . ASP A 1 339 ? 59.83900 -15.73400 26.85500 1.000 49.27537 ? 333 ASP A OD1 1 
ATOM   2480 O  OD2 . ASP A 1 339 ? 58.45300 -14.17700 26.15100 1.000 48.33171 ? 333 ASP A OD2 1 
ATOM   2481 N  N   . ILE A 1 340 ? 57.77000 -13.98400 31.32700 1.000 46.01836 ? 334 ILE A N   1 
ATOM   2482 C  CA  . ILE A 1 340 ? 57.55100 -13.57800 32.71500 1.000 45.88411 ? 334 ILE A CA  1 
ATOM   2483 C  C   . ILE A 1 340 ? 57.97000 -14.70300 33.64900 1.000 43.61882 ? 334 ILE A C   1 
ATOM   2484 O  O   . ILE A 1 340 ? 58.65200 -14.48600 34.66100 1.000 49.18577 ? 334 ILE A O   1 
ATOM   2485 C  CB  . ILE A 1 340 ? 56.07200 -13.19700 32.93800 1.000 49.25329 ? 334 ILE A CB  1 
ATOM   2486 C  CG1 . ILE A 1 340 ? 55.67800 -11.98100 32.10500 1.000 47.13074 ? 334 ILE A CG1 1 
ATOM   2487 C  CG2 . ILE A 1 340 ? 55.79700 -12.91100 34.41000 1.000 42.41849 ? 334 ILE A CG2 1 
ATOM   2488 C  CD1 . ILE A 1 340 ? 56.58100 -10.79600 32.32300 1.000 51.05768 ? 334 ILE A CD1 1 
ATOM   2489 N  N   . HIS A 1 341 ? 57.55100 -15.92800 33.31900 1.000 43.45299 ? 335 HIS A N   1 
ATOM   2490 C  CA  . HIS A 1 341 ? 57.87400 -17.09300 34.13500 1.000 43.69934 ? 335 HIS A CA  1 
ATOM   2491 C  C   . HIS A 1 341 ? 59.38100 -17.25100 34.30000 1.000 46.72207 ? 335 HIS A C   1 
ATOM   2492 O  O   . HIS A 1 341 ? 59.86100 -17.62700 35.37600 1.000 43.64582 ? 335 HIS A O   1 
ATOM   2493 C  CB  . HIS A 1 341 ? 57.25800 -18.34200 33.49700 1.000 44.61470 ? 335 HIS A CB  1 
ATOM   2494 C  CG  . HIS A 1 341 ? 57.83800 -19.63400 33.98600 1.000 44.22302 ? 335 HIS A CG  1 
ATOM   2495 N  ND1 . HIS A 1 341 ? 57.58600 -20.13300 35.24500 1.000 41.85872 ? 335 HIS A ND1 1 
ATOM   2496 C  CD2 . HIS A 1 341 ? 58.63800 -20.54100 33.37600 1.000 47.76656 ? 335 HIS A CD2 1 
ATOM   2497 C  CE1 . HIS A 1 341 ? 58.21700 -21.28400 35.39600 1.000 40.68468 ? 335 HIS A CE1 1 
ATOM   2498 N  NE2 . HIS A 1 341 ? 58.86100 -21.55500 34.27500 1.000 45.76080 ? 335 HIS A NE2 1 
ATOM   2499 N  N   . LYS A 1 342 ? 60.14500 -16.95600 33.24500 1.000 47.12766 ? 336 LYS A N   1 
ATOM   2500 C  CA  . LYS A 1 342 ? 61.59200 -17.12400 33.30100 1.000 51.17559 ? 336 LYS A CA  1 
ATOM   2501 C  C   . LYS A 1 342 ? 62.30200 -15.98800 34.02500 1.000 52.31583 ? 336 LYS A C   1 
ATOM   2502 O  O   . LYS A 1 342 ? 63.49900 -16.11200 34.31200 1.000 57.02697 ? 336 LYS A O   1 
ATOM   2503 C  CB  . LYS A 1 342 ? 62.15400 -17.26800 31.88700 1.000 49.75865 ? 336 LYS A CB  1 
ATOM   2504 C  CG  . LYS A 1 342 ? 61.90000 -18.63500 31.26100 1.000 51.64835 ? 336 LYS A CG  1 
ATOM   2505 C  CD  . LYS A 1 342 ? 61.92500 -18.54900 29.74000 1.000 63.40575 ? 336 LYS A CD  1 
ATOM   2506 C  CE  . LYS A 1 342 ? 62.50000 -19.81100 29.11000 1.000 58.84729 ? 336 LYS A CE  1 
ATOM   2507 N  NZ  . LYS A 1 342 ? 61.56200 -20.43900 28.13400 1.000 66.54679 ? 336 LYS A NZ  1 
ATOM   2508 N  N   . ILE A 1 343 ? 61.61500 -14.89300 34.33200 1.000 50.85112 ? 337 ILE A N   1 
ATOM   2509 C  CA  . ILE A 1 343 ? 62.24600 -13.79000 35.03800 1.000 49.61514 ? 337 ILE A CA  1 
ATOM   2510 C  C   . ILE A 1 343 ? 61.69300 -13.64900 36.45400 1.000 51.16258 ? 337 ILE A C   1 
ATOM   2511 O  O   . ILE A 1 343 ? 61.87800 -12.61300 37.09300 1.000 53.20702 ? 337 ILE A O   1 
ATOM   2512 C  CB  . ILE A 1 343 ? 62.13100 -12.48000 34.24300 1.000 54.70047 ? 337 ILE A CB  1 
ATOM   2513 C  CG1 . ILE A 1 343 ? 60.67700 -12.01800 34.13300 1.000 50.41026 ? 337 ILE A CG1 1 
ATOM   2514 C  CG2 . ILE A 1 343 ? 62.73300 -12.65900 32.85600 1.000 53.12067 ? 337 ILE A CG2 1 
ATOM   2515 C  CD1 . ILE A 1 343 ? 60.56100 -10.56100 33.76800 1.000 46.59127 ? 337 ILE A CD1 1 
ATOM   2516 N  N   . GLY A 1 344 ? 61.03900 -14.68800 36.96600 1.000 42.22994 ? 338 GLY A N   1 
ATOM   2517 C  CA  . GLY A 1 344 ? 60.49400 -14.65700 38.31300 1.000 43.24837 ? 338 GLY A CA  1 
ATOM   2518 C  C   . GLY A 1 344 ? 58.98400 -14.80400 38.41500 1.000 44.82323 ? 338 GLY A C   1 
ATOM   2519 O  O   . GLY A 1 344 ? 58.46600 -14.84100 39.54200 1.000 38.26360 ? 338 GLY A O   1 
ATOM   2520 N  N   . GLY A 1 345 ? 58.24400 -14.88100 37.30400 1.000 40.74968 ? 339 GLY A N   1 
ATOM   2521 C  CA  . GLY A 1 345 ? 56.82200 -15.18000 37.35500 1.000 33.19486 ? 339 GLY A CA  1 
ATOM   2522 C  C   . GLY A 1 345 ? 55.95900 -14.02100 37.83400 1.000 39.32269 ? 339 GLY A C   1 
ATOM   2523 O  O   . GLY A 1 345 ? 56.41400 -12.89400 38.04100 1.000 35.79194 ? 339 GLY A O   1 
ATOM   2524 N  N   . THR A 1 346 ? 54.66600 -14.32200 38.00500 1.000 33.05314 ? 340 THR A N   1 
ATOM   2525 C  CA  . THR A 1 346 ? 53.73100 -13.30200 38.47000 1.000 30.29892 ? 340 THR A CA  1 
ATOM   2526 C  C   . THR A 1 346 ? 54.08000 -12.75000 39.85000 1.000 30.26378 ? 340 THR A C   1 
ATOM   2527 O  O   . THR A 1 346 ? 53.96700 -11.52500 40.03500 1.000 27.93956 ? 340 THR A O   1 
ATOM   2528 C  CB  . THR A 1 346 ? 52.29800 -13.86000 38.43800 1.000 30.98323 ? 340 THR A CB  1 
ATOM   2529 O  OG1 . THR A 1 346 ? 51.97400 -14.20500 37.08500 1.000 28.67130 ? 340 THR A OG1 1 
ATOM   2530 C  CG2 . THR A 1 346 ? 51.29000 -12.81500 38.94000 1.000 24.83708 ? 340 THR A CG2 1 
ATOM   2531 N  N   . PRO A 1 347 ? 54.50600 -13.55200 40.83600 1.000 27.52041 ? 341 PRO A N   1 
ATOM   2532 C  CA  . PRO A 1 347 ? 54.91000 -12.94100 42.11900 1.000 34.67462 ? 341 PRO A CA  1 
ATOM   2533 C  C   . PRO A 1 347 ? 56.00900 -11.88600 41.97300 1.000 32.42059 ? 341 PRO A C   1 
ATOM   2534 O  O   . PRO A 1 347 ? 55.94900 -10.84100 42.63700 1.000 35.05444 ? 341 PRO A O   1 
ATOM   2535 C  CB  . PRO A 1 347 ? 55.36100 -14.15300 42.94900 1.000 29.59622 ? 341 PRO A CB  1 
ATOM   2536 C  CG  . PRO A 1 347 ? 54.52300 -15.31400 42.38800 1.000 27.30915 ? 341 PRO A CG  1 
ATOM   2537 C  CD  . PRO A 1 347 ? 54.52700 -15.03100 40.90300 1.000 27.45766 ? 341 PRO A CD  1 
ATOM   2538 N  N   . ALA A 1 348 ? 56.99000 -12.10500 41.09300 1.000 31.73785 ? 342 ALA A N   1 
ATOM   2539 C  CA  . ALA A 1 348 ? 58.02900 -11.09400 40.90100 1.000 33.13874 ? 342 ALA A CA  1 
ATOM   2540 C  C   . ALA A 1 348 ? 57.44200 -9.78400  40.37700 1.000 38.86459 ? 342 ALA A C   1 
ATOM   2541 O  O   . ALA A 1 348 ? 57.83600 -8.69700  40.82000 1.000 38.46525 ? 342 ALA A O   1 
ATOM   2542 C  CB  . ALA A 1 348 ? 59.11000 -11.61800 39.95700 1.000 38.60250 ? 342 ALA A CB  1 
ATOM   2543 N  N   . VAL A 1 349 ? 56.49800 -9.86500  39.43300 1.000 34.20541 ? 343 VAL A N   1 
ATOM   2544 C  CA  . VAL A 1 349 ? 55.83400 -8.65600  38.94800 1.000 35.68281 ? 343 VAL A CA  1 
ATOM   2545 C  C   . VAL A 1 349 ? 55.08900 -7.96700  40.07800 1.000 31.60361 ? 343 VAL A C   1 
ATOM   2546 O  O   . VAL A 1 349 ? 55.17400 -6.74600  40.24800 1.000 34.42288 ? 343 VAL A O   1 
ATOM   2547 C  CB  . VAL A 1 349 ? 54.88300 -8.99600  37.79000 1.000 35.21436 ? 343 VAL A CB  1 
ATOM   2548 C  CG1 . VAL A 1 349 ? 54.19600 -7.74800  37.31200 1.000 30.67749 ? 343 VAL A CG1 1 
ATOM   2549 C  CG2 . VAL A 1 349 ? 55.64600 -9.66700  36.67100 1.000 38.95296 ? 343 VAL A CG2 1 
ATOM   2550 N  N   . LEU A 1 350 ? 54.31600 -8.73700  40.85000 1.000 29.16558 ? 344 LEU A N   1 
ATOM   2551 C  CA  . LEU A 1 350 ? 53.52400 -8.14200  41.91900 1.000 29.39914 ? 344 LEU A CA  1 
ATOM   2552 C  C   . LEU A 1 350 ? 54.41300 -7.57900  43.02700 1.000 32.88025 ? 344 LEU A C   1 
ATOM   2553 O  O   . LEU A 1 350 ? 54.04200 -6.59500  43.67200 1.000 28.23877 ? 344 LEU A O   1 
ATOM   2554 C  CB  . LEU A 1 350 ? 52.55500 -9.17700  42.50300 1.000 30.40318 ? 344 LEU A CB  1 
ATOM   2555 C  CG  . LEU A 1 350 ? 51.59300 -9.83300  41.50100 1.000 29.32225 ? 344 LEU A CG  1 
ATOM   2556 C  CD1 . LEU A 1 350 ? 50.61100 -10.72600 42.22600 1.000 28.03999 ? 344 LEU A CD1 1 
ATOM   2557 C  CD2 . LEU A 1 350 ? 50.85800 -8.77500  40.69100 1.000 22.27140 ? 344 LEU A CD2 1 
ATOM   2558 N  N   . ARG A 1 351 ? 55.56200 -8.21500  43.28500 1.000 34.91341 ? 345 ARG A N   1 
ATOM   2559 C  CA  . ARG A 1 351 ? 56.50900 -7.67500  44.25900 1.000 37.02239 ? 345 ARG A CA  1 
ATOM   2560 C  C   . ARG A 1 351 ? 56.96900 -6.28300  43.86000 1.000 33.97711 ? 345 ARG A C   1 
ATOM   2561 O  O   . ARG A 1 351 ? 57.03300 -5.37600  44.69800 1.000 39.60831 ? 345 ARG A O   1 
ATOM   2562 C  CB  . ARG A 1 351 ? 57.71500 -8.59500  44.38900 1.000 41.51076 ? 345 ARG A CB  1 
ATOM   2563 C  CG  . ARG A 1 351 ? 58.76100 -8.07000  45.36300 1.000 48.11452 ? 345 ARG A CG  1 
ATOM   2564 C  CD  . ARG A 1 351 ? 59.80600 -9.12400  45.66900 1.000 54.36709 ? 345 ARG A CD  1 
ATOM   2565 N  NE  . ARG A 1 351 ? 60.99000 -8.52700  46.27400 1.000 62.51768 ? 345 ARG A NE  1 
ATOM   2566 C  CZ  . ARG A 1 351 ? 61.68000 -9.07800  47.26100 1.000 61.45819 ? 345 ARG A CZ  1 
ATOM   2567 N  NH1 . ARG A 1 351 ? 61.34400 -10.25600 47.76400 1.000 53.79555 ? 345 ARG A NH1 1 
ATOM   2568 N  NH2 . ARG A 1 351 ? 62.73000 -8.43000  47.75700 1.000 61.83743 ? 345 ARG A NH2 1 
ATOM   2569 N  N   . TYR A 1 352 ? 57.28800 -6.09900  42.57500 1.000 32.77240 ? 346 TYR A N   1 
ATOM   2570 C  CA  . TYR A 1 352 ? 57.67900 -4.78400  42.07200 1.000 38.91614 ? 346 TYR A CA  1 
ATOM   2571 C  C   . TYR A 1 352 ? 56.54400 -3.77400  42.22100 1.000 41.23554 ? 346 TYR A C   1 
ATOM   2572 O  O   . TYR A 1 352 ? 56.75000 -2.66500  42.73100 1.000 37.05045 ? 346 TYR A O   1 
ATOM   2573 C  CB  . TYR A 1 352 ? 58.12600 -4.90600  40.61400 1.000 39.00358 ? 346 TYR A CB  1 
ATOM   2574 C  CG  . TYR A 1 352 ? 58.59900 -3.60900  39.99900 1.000 43.01161 ? 346 TYR A CG  1 
ATOM   2575 C  CD1 . TYR A 1 352 ? 59.50600 -2.78400  40.66200 1.000 44.74467 ? 346 TYR A CD1 1 
ATOM   2576 C  CD2 . TYR A 1 352 ? 58.12800 -3.20400  38.75800 1.000 44.25883 ? 346 TYR A CD2 1 
ATOM   2577 C  CE1 . TYR A 1 352 ? 59.93000 -1.59100  40.09600 1.000 45.76736 ? 346 TYR A CE1 1 
ATOM   2578 C  CE2 . TYR A 1 352 ? 58.54300 -2.02100  38.18300 1.000 51.04296 ? 346 TYR A CE2 1 
ATOM   2579 C  CZ  . TYR A 1 352 ? 59.44000 -1.21500  38.85300 1.000 53.43329 ? 346 TYR A CZ  1 
ATOM   2580 O  OH  . TYR A 1 352 ? 59.83400 -0.03700  38.26100 1.000 57.66166 ? 346 TYR A OH  1 
ATOM   2581 N  N   . LEU A 1 353 ? 55.32500 -4.14700  41.80800 1.000 36.19600 ? 347 LEU A N   1 
ATOM   2582 C  CA  . LEU A 1 353 ? 54.19300 -3.23200  41.95100 1.000 33.62772 ? 347 LEU A CA  1 
ATOM   2583 C  C   . LEU A 1 353 ? 53.91700 -2.89900  43.41300 1.000 33.35746 ? 347 LEU A C   1 
ATOM   2584 O  O   . LEU A 1 353 ? 53.57500 -1.75900  43.74100 1.000 35.93583 ? 347 LEU A O   1 
ATOM   2585 C  CB  . LEU A 1 353 ? 52.94000 -3.82700  41.29600 1.000 38.27121 ? 347 LEU A CB  1 
ATOM   2586 C  CG  . LEU A 1 353 ? 53.02200 -4.14400  39.79800 1.000 35.98080 ? 347 LEU A CG  1 
ATOM   2587 C  CD1 . LEU A 1 353 ? 51.68200 -4.64500  39.27300 1.000 28.92849 ? 347 LEU A CD1 1 
ATOM   2588 C  CD2 . LEU A 1 353 ? 53.49900 -2.93600  38.97100 1.000 35.33981 ? 347 LEU A CD2 1 
ATOM   2589 N  N   . LEU A 1 354 ? 54.03800 -3.88400  44.30800 1.000 33.31373 ? 348 LEU A N   1 
ATOM   2590 C  CA  . LEU A 1 354 ? 53.86900 -3.61400  45.73500 1.000 36.22544 ? 348 LEU A CA  1 
ATOM   2591 C  C   . LEU A 1 354 ? 54.95100 -2.66900  46.24500 1.000 35.53758 ? 348 LEU A C   1 
ATOM   2592 O  O   . LEU A 1 354 ? 54.66400 -1.73300  47.00400 1.000 38.41404 ? 348 LEU A O   1 
ATOM   2593 C  CB  . LEU A 1 354 ? 53.88100 -4.92500  46.53200 1.000 33.62836 ? 348 LEU A CB  1 
ATOM   2594 C  CG  . LEU A 1 354 ? 53.83100 -4.84400  48.06600 1.000 34.92817 ? 348 LEU A CG  1 
ATOM   2595 C  CD1 . LEU A 1 354 ? 52.49700 -4.32300  48.58500 1.000 33.04357 ? 348 LEU A CD1 1 
ATOM   2596 C  CD2 . LEU A 1 354 ? 54.12400 -6.20700  48.66400 1.000 39.44862 ? 348 LEU A CD2 1 
ATOM   2597 N  N   . GLU A 1 355 ? 56.19700 -2.88400  45.81800 1.000 37.02635 ? 349 GLU A N   1 
ATOM   2598 C  CA  . GLU A 1 355 ? 57.27900 -1.98400  46.21500 1.000 42.61371 ? 349 GLU A CA  1 
ATOM   2599 C  C   . GLU A 1 355 ? 57.00800 -0.55900  45.75400 1.000 42.16634 ? 349 GLU A C   1 
ATOM   2600 O  O   . GLU A 1 355 ? 57.28500 0.39800   46.48600 1.000 43.77298 ? 349 GLU A O   1 
ATOM   2601 C  CB  . GLU A 1 355 ? 58.61000 -2.49000  45.66800 1.000 42.49108 ? 349 GLU A CB  1 
ATOM   2602 C  CG  . GLU A 1 355 ? 59.19300 -3.59300  46.53300 1.000 49.82635 ? 349 GLU A CG  1 
ATOM   2603 C  CD  . GLU A 1 355 ? 60.31100 -4.36400  45.86400 1.000 51.96807 ? 349 GLU A CD  1 
ATOM   2604 O  OE1 . GLU A 1 355 ? 60.72700 -3.99800  44.74100 1.000 53.50318 ? 349 GLU A OE1 1 
ATOM   2605 O  OE2 . GLU A 1 355 ? 60.77300 -5.34900  46.47200 1.000 56.58689 ? 349 GLU A OE2 1 
ATOM   2606 N  N   . LEU A 1 356 ? 56.43000 -0.40100  44.56000 1.000 38.69102 ? 350 LEU A N   1 
ATOM   2607 C  CA  . LEU A 1 356 ? 56.03400 0.90900   44.05800 1.000 36.43715 ? 350 LEU A CA  1 
ATOM   2608 C  C   . LEU A 1 356 ? 54.84800 1.50700   44.80500 1.000 36.89523 ? 350 LEU A C   1 
ATOM   2609 O  O   . LEU A 1 356 ? 54.43800 2.62900   44.47600 1.000 41.73439 ? 350 LEU A O   1 
ATOM   2610 C  CB  . LEU A 1 356 ? 55.69700 0.81900   42.56700 1.000 38.96983 ? 350 LEU A CB  1 
ATOM   2611 C  CG  . LEU A 1 356 ? 56.78000 0.30200   41.61800 1.000 42.26750 ? 350 LEU A CG  1 
ATOM   2612 C  CD1 . LEU A 1 356 ? 56.36600 0.49900   40.16500 1.000 40.37661 ? 350 LEU A CD1 1 
ATOM   2613 C  CD2 . LEU A 1 356 ? 58.10900 0.98300   41.90300 1.000 46.25753 ? 350 LEU A CD2 1 
ATOM   2614 N  N   . GLY A 1 357 ? 54.28300 0.80600   45.78600 1.000 39.26037 ? 351 GLY A N   1 
ATOM   2615 C  CA  . GLY A 1 357 ? 53.10800 1.31300   46.47900 1.000 35.21328 ? 351 GLY A CA  1 
ATOM   2616 C  C   . GLY A 1 357 ? 51.83300 1.28000   45.66700 1.000 37.09521 ? 351 GLY A C   1 
ATOM   2617 O  O   . GLY A 1 357 ? 50.86900 1.97600   46.00200 1.000 40.33049 ? 351 GLY A O   1 
ATOM   2618 N  N   . LEU A 1 358 ? 51.80100 0.49300   44.59300 1.000 36.45903 ? 352 LEU A N   1 
ATOM   2619 C  CA  . LEU A 1 358 ? 50.60900 0.37300   43.76100 1.000 37.89753 ? 352 LEU A CA  1 
ATOM   2620 C  C   . LEU A 1 358 ? 49.62200 -0.66300  44.28200 1.000 40.40412 ? 352 LEU A C   1 
ATOM   2621 O  O   . LEU A 1 358 ? 48.47600 -0.69700  43.82200 1.000 40.98215 ? 352 LEU A O   1 
ATOM   2622 C  CB  . LEU A 1 358 ? 51.02500 0.01800   42.33400 1.000 36.35338 ? 352 LEU A CB  1 
ATOM   2623 C  CG  . LEU A 1 358 ? 51.92800 1.08900   41.71300 1.000 37.66272 ? 352 LEU A CG  1 
ATOM   2624 C  CD1 . LEU A 1 358 ? 52.45300 0.64500   40.35800 1.000 36.30440 ? 352 LEU A CD1 1 
ATOM   2625 C  CD2 . LEU A 1 358 ? 51.17100 2.39800   41.60300 1.000 35.63862 ? 352 LEU A CD2 1 
ATOM   2626 N  N   . MET A 1 359 ? 50.02900 -1.49000  45.23400 1.000 40.46993 ? 353 MET A N   1 
ATOM   2627 C  CA  . MET A 1 359 ? 49.23600 -2.62300  45.66300 1.000 33.12068 ? 353 MET A CA  1 
ATOM   2628 C  C   . MET A 1 359 ? 49.11600 -2.60700  47.17500 1.000 42.80456 ? 353 MET A C   1 
ATOM   2629 O  O   . MET A 1 359 ? 50.00400 -2.10100  47.87400 1.000 43.35561 ? 353 MET A O   1 
ATOM   2630 C  CB  . MET A 1 359 ? 49.87600 -3.90800  45.18800 1.000 36.60581 ? 353 MET A CB  1 
ATOM   2631 C  CG  . MET A 1 359 ? 49.50900 -4.21500  43.75100 1.000 38.16358 ? 353 MET A CG  1 
ATOM   2632 S  SD  . MET A 1 359 ? 50.20500 -5.76600  43.25000 1.000 42.49142 ? 353 MET A SD  1 
ATOM   2633 C  CE  . MET A 1 359 ? 48.77300 -6.83300  43.42200 1.000 33.51286 ? 353 MET A CE  1 
ATOM   2634 N  N   . ASP A 1 360 ? 48.02300 -3.16700  47.70300 1.000 36.56667 ? 354 ASP A N   1 
ATOM   2635 C  CA  . ASP A 1 360 ? 47.92600 -3.28800  49.14900 1.000 39.29166 ? 354 ASP A CA  1 
ATOM   2636 C  C   . ASP A 1 360 ? 48.37400 -4.66600  49.58600 1.000 38.92721 ? 354 ASP A C   1 
ATOM   2637 O  O   . ASP A 1 360 ? 47.75700 -5.67900  49.23700 1.000 36.21456 ? 354 ASP A O   1 
ATOM   2638 C  CB  . ASP A 1 360 ? 46.54700 -2.97100  49.70100 1.000 35.74901 ? 354 ASP A CB  1 
ATOM   2639 C  CG  . ASP A 1 360 ? 46.44500 -3.30300  51.18500 1.000 49.34940 ? 354 ASP A CG  1 
ATOM   2640 O  OD1 . ASP A 1 360 ? 46.69200 -4.43800  51.63700 1.000 53.87575 ? 354 ASP A OD1 1 
ATOM   2641 O  OD2 . ASP A 1 360 ? 46.37700 -2.32500  51.94500 1.000 61.22312 ? 354 ASP A OD2 1 
ATOM   2642 N  N   . GLY A 1 361 ? 49.42400 -4.68200  50.39700 1.000 38.30603 ? 355 GLY A N   1 
ATOM   2643 C  CA  . GLY A 1 361 ? 49.99200 -5.91000  50.88400 1.000 32.60768 ? 355 GLY A CA  1 
ATOM   2644 C  C   . GLY A 1 361 ? 49.24900 -6.57600  52.01500 1.000 31.22171 ? 355 GLY A C   1 
ATOM   2645 O  O   . GLY A 1 361 ? 49.55300 -7.73400  52.29100 1.000 35.27896 ? 355 GLY A O   1 
ATOM   2646 N  N   . ASP A 1 362 ? 48.29600 -5.90200  52.67500 1.000 32.39292 ? 356 ASP A N   1 
ATOM   2647 C  CA  . ASP A 1 362 ? 47.62000 -6.47700  53.83900 1.000 37.70676 ? 356 ASP A CA  1 
ATOM   2648 C  C   . ASP A 1 362 ? 46.47300 -7.43200  53.48400 1.000 36.13048 ? 356 ASP A C   1 
ATOM   2649 O  O   . ASP A 1 362 ? 45.85000 -7.97400  54.39900 1.000 33.20638 ? 356 ASP A O   1 
ATOM   2650 C  CB  . ASP A 1 362 ? 47.04800 -5.37900  54.75800 1.000 41.89322 ? 356 ASP A CB  1 
ATOM   2651 C  CG  . ASP A 1 362 ? 48.10000 -4.41100  55.27700 1.000 52.45688 ? 356 ASP A CG  1 
ATOM   2652 O  OD1 . ASP A 1 362 ? 49.29500 -4.77200  55.33800 1.000 50.92321 ? 356 ASP A OD1 1 
ATOM   2653 O  OD2 . ASP A 1 362 ? 47.71100 -3.28300  55.65500 1.000 58.89616 ? 356 ASP A OD2 1 
ATOM   2654 N  N   . CYS A 1 363 ? 46.16100 -7.62900  52.20200 1.000 30.32070 ? 357 CYS A N   1 
ATOM   2655 C  CA  . CYS A 1 363 ? 45.06800 -8.51000  51.80100 1.000 32.09474 ? 357 CYS A CA  1 
ATOM   2656 C  C   . CYS A 1 363 ? 45.41700 -9.96900  52.07500 1.000 23.96483 ? 357 CYS A C   1 
ATOM   2657 O  O   . CYS A 1 363 ? 46.47000 -10.44700 51.65800 1.000 29.75466 ? 357 CYS A O   1 
ATOM   2658 C  CB  . CYS A 1 363 ? 44.77900 -8.32200  50.31100 1.000 32.88366 ? 357 CYS A CB  1 
ATOM   2659 S  SG  . CYS A 1 363 ? 44.30500 -6.65800  49.88000 1.000 32.96629 ? 357 CYS A SG  1 
ATOM   2660 N  N   . MET A 1 364 ? 44.53300 -10.67300 52.77400 1.000 26.14292 ? 358 MET A N   1 
ATOM   2661 C  CA  . MET A 1 364 ? 44.67700 -12.11300 52.96300 1.000 26.50200 ? 358 MET A CA  1 
ATOM   2662 C  C   . MET A 1 364 ? 44.52700 -12.86200 51.63900 1.000 27.73820 ? 358 MET A C   1 
ATOM   2663 O  O   . MET A 1 364 ? 43.78900 -12.43300 50.75100 1.000 26.60464 ? 358 MET A O   1 
ATOM   2664 C  CB  . MET A 1 364 ? 43.63200 -12.61200 53.96300 1.000 28.20555 ? 358 MET A CB  1 
ATOM   2665 C  CG  . MET A 1 364 ? 43.76200 -11.95100 55.32300 1.000 31.16580 ? 358 MET A CG  1 
ATOM   2666 S  SD  . MET A 1 364 ? 45.38700 -12.40100 56.01300 1.000 36.29769 ? 358 MET A SD  1 
ATOM   2667 C  CE  . MET A 1 364 ? 45.33200 -14.18600 56.03900 1.000 35.35755 ? 358 MET A CE  1 
ATOM   2668 N  N   . THR A 1 365 ? 45.22600 -14.00100 51.52800 1.000 28.15772 ? 359 THR A N   1 
ATOM   2669 C  CA  . THR A 1 365 ? 45.24800 -14.84700 50.33700 1.000 27.25191 ? 359 THR A CA  1 
ATOM   2670 C  C   . THR A 1 365 ? 45.07800 -16.31700 50.71100 1.000 27.74585 ? 359 THR A C   1 
ATOM   2671 O  O   . THR A 1 365 ? 45.12600 -16.70400 51.88900 1.000 30.10651 ? 359 THR A O   1 
ATOM   2672 C  CB  . THR A 1 365 ? 46.56100 -14.72100 49.54300 1.000 25.14240 ? 359 THR A CB  1 
ATOM   2673 O  OG1 . THR A 1 365 ? 47.56600 -15.55900 50.14400 1.000 27.18837 ? 359 THR A OG1 1 
ATOM   2674 C  CG2 . THR A 1 365 ? 47.05300 -13.26700 49.47000 1.000 31.24871 ? 359 THR A CG2 1 
ATOM   2675 N  N   . VAL A 1 366 ? 44.95200 -17.15400 49.67600 1.000 22.86617 ? 360 VAL A N   1 
ATOM   2676 C  CA  . VAL A 1 366 ? 44.74100 -18.58900 49.87400 1.000 24.73802 ? 360 VAL A CA  1 
ATOM   2677 C  C   . VAL A 1 366 ? 45.95600 -19.31100 50.44900 1.000 25.34307 ? 360 VAL A C   1 
ATOM   2678 O  O   . VAL A 1 366 ? 45.86300 -20.50300 50.76300 1.000 25.16404 ? 360 VAL A O   1 
ATOM   2679 C  CB  . VAL A 1 366 ? 44.31100 -19.26800 48.55400 1.000 23.37596 ? 360 VAL A CB  1 
ATOM   2680 C  CG1 . VAL A 1 366 ? 42.89800 -18.81300 48.16800 1.000 20.25463 ? 360 VAL A CG1 1 
ATOM   2681 C  CG2 . VAL A 1 366 ? 45.30800 -18.99300 47.41100 1.000 20.62456 ? 360 VAL A CG2 1 
ATOM   2682 N  N   . THR A 1 367 ? 47.10200 -18.63700 50.59600 1.000 24.57958 ? 361 THR A N   1 
ATOM   2683 C  CA  . THR A 1 367 ? 48.19600 -19.25300 51.34300 1.000 24.71954 ? 361 THR A CA  1 
ATOM   2684 C  C   . THR A 1 367 ? 47.95200 -19.21500 52.84000 1.000 28.94374 ? 361 THR A C   1 
ATOM   2685 O  O   . THR A 1 367 ? 48.70600 -19.83800 53.58900 1.000 32.50130 ? 361 THR A O   1 
ATOM   2686 C  CB  . THR A 1 367 ? 49.53000 -18.54900 51.08300 1.000 25.74638 ? 361 THR A CB  1 
ATOM   2687 O  OG1 . THR A 1 367 ? 49.49600 -17.26300 51.70400 1.000 26.27983 ? 361 THR A OG1 1 
ATOM   2688 C  CG2 . THR A 1 367 ? 49.76900 -18.36600 49.60700 1.000 31.10715 ? 361 THR A CG2 1 
ATOM   2689 N  N   . GLY A 1 368 ? 46.92300 -18.50500 53.28600 1.000 31.65011 ? 362 GLY A N   1 
ATOM   2690 C  CA  . GLY A 1 368 ? 46.72200 -18.24700 54.69200 1.000 31.42140 ? 362 GLY A CA  1 
ATOM   2691 C  C   . GLY A 1 368 ? 47.47200 -17.04200 55.20200 1.000 34.48419 ? 362 GLY A C   1 
ATOM   2692 O  O   . GLY A 1 368 ? 47.30700 -16.68000 56.36600 1.000 35.28624 ? 362 GLY A O   1 
ATOM   2693 N  N   . GLN A 1 369 ? 48.27800 -16.40900 54.36600 1.000 31.88590 ? 363 GLN A N   1 
ATOM   2694 C  CA  . GLN A 1 369 ? 49.04900 -15.22900 54.72000 1.000 38.03348 ? 363 GLN A CA  1 
ATOM   2695 C  C   . GLN A 1 369 ? 48.63300 -14.07400 53.82200 1.000 39.04225 ? 363 GLN A C   1 
ATOM   2696 O  O   . GLN A 1 369 ? 47.84400 -14.23600 52.88100 1.000 32.78754 ? 363 GLN A O   1 
ATOM   2697 C  CB  . GLN A 1 369 ? 50.54500 -15.50700 54.58300 1.000 36.66132 ? 363 GLN A CB  1 
ATOM   2698 C  CG  . GLN A 1 369 ? 51.04800 -16.57800 55.51700 1.000 44.84167 ? 363 GLN A CG  1 
ATOM   2699 C  CD  . GLN A 1 369 ? 52.50500 -16.87200 55.26700 1.000 53.97809 ? 363 GLN A CD  1 
ATOM   2700 O  OE1 . GLN A 1 369 ? 53.33200 -15.96200 55.26700 1.000 49.03092 ? 363 GLN A OE1 1 
ATOM   2701 N  NE2 . GLN A 1 369 ? 52.83100 -18.14500 55.03500 1.000 59.57671 ? 363 GLN A NE2 1 
ATOM   2702 N  N   . THR A 1 370 ? 49.19000 -12.90200 54.10000 1.000 34.54384 ? 364 THR A N   1 
ATOM   2703 C  CA  . THR A 1 370 ? 48.87800 -11.74400 53.28400 1.000 32.89745 ? 364 THR A CA  1 
ATOM   2704 C  C   . THR A 1 370 ? 49.68200 -11.76600 51.98900 1.000 25.41385 ? 364 THR A C   1 
ATOM   2705 O  O   . THR A 1 370 ? 50.67900 -12.48500 51.84800 1.000 30.93684 ? 364 THR A O   1 
ATOM   2706 C  CB  . THR A 1 370 ? 49.17800 -10.44700 54.03800 1.000 37.66736 ? 364 THR A CB  1 
ATOM   2707 O  OG1 . THR A 1 370 ? 50.59000 -10.37000 54.26100 1.000 33.22707 ? 364 THR A OG1 1 
ATOM   2708 C  CG2 . THR A 1 370 ? 48.42600 -10.40000 55.37400 1.000 32.13598 ? 364 THR A CG2 1 
ATOM   2709 N  N   . LEU A 1 371 ? 49.24100 -10.94000 51.04200 1.000 29.43006 ? 365 LEU A N   1 
ATOM   2710 C  CA  . LEU A 1 371 ? 49.99200 -10.74400 49.80600 1.000 27.76075 ? 365 LEU A CA  1 
ATOM   2711 C  C   . LEU A 1 371 ? 51.43600 -10.31900 50.09600 1.000 30.40086 ? 365 LEU A C   1 
ATOM   2712 O  O   . LEU A 1 371 ? 52.38700 -10.87700 49.53600 1.000 34.49719 ? 365 LEU A O   1 
ATOM   2713 C  CB  . LEU A 1 371 ? 49.27600 -9.70400  48.93400 1.000 30.57932 ? 365 LEU A CB  1 
ATOM   2714 C  CG  . LEU A 1 371 ? 50.01600 -9.25700  47.66900 1.000 28.59297 ? 365 LEU A CG  1 
ATOM   2715 C  CD1 . LEU A 1 371 ? 50.08100 -10.38800 46.66600 1.000 31.46885 ? 365 LEU A CD1 1 
ATOM   2716 C  CD2 . LEU A 1 371 ? 49.34700 -8.03200  47.05600 1.000 35.72703 ? 365 LEU A CD2 1 
ATOM   2717 N  N   . ALA A 1 372 ? 51.61200 -9.34000  50.98900 1.000 32.50845 ? 366 ALA A N   1 
ATOM   2718 C  CA  . ALA A 1 372 ? 52.95900 -8.89900  51.35900 1.000 35.06187 ? 366 ALA A CA  1 
ATOM   2719 C  C   . ALA A 1 372 ? 53.79400 -10.04700 51.91500 1.000 33.32375 ? 366 ALA A C   1 
ATOM   2720 O  O   . ALA A 1 372 ? 54.97400 -10.19500 51.56700 1.000 38.17073 ? 366 ALA A O   1 
ATOM   2721 C  CB  . ALA A 1 372 ? 52.87100 -7.76200  52.37600 1.000 40.06179 ? 366 ALA A CB  1 
ATOM   2722 N  N   . GLN A 1 373 ? 53.19800 -10.87700 52.77600 1.000 35.35407 ? 367 GLN A N   1 
ATOM   2723 C  CA  . GLN A 1 373 ? 53.92000 -12.01600 53.33200 1.000 35.36042 ? 367 GLN A CA  1 
ATOM   2724 C  C   . GLN A 1 373 ? 54.32200 -13.00600 52.24200 1.000 40.08188 ? 367 GLN A C   1 
ATOM   2725 O  O   . GLN A 1 373 ? 55.44900 -13.52100 52.25200 1.000 36.05328 ? 367 GLN A O   1 
ATOM   2726 C  CB  . GLN A 1 373 ? 53.07700 -12.69500 54.41900 1.000 42.49772 ? 367 GLN A CB  1 
ATOM   2727 C  CG  . GLN A 1 373 ? 53.05100 -11.90200 55.73500 1.000 37.64841 ? 367 GLN A CG  1 
ATOM   2728 C  CD  . GLN A 1 373 ? 52.01000 -12.37200 56.76100 1.000 48.07465 ? 367 GLN A CD  1 
ATOM   2729 O  OE1 . GLN A 1 373 ? 50.90900 -12.80400 56.42000 1.000 38.54638 ? 367 GLN A OE1 1 
ATOM   2730 N  NE2 . GLN A 1 373 ? 52.36200 -12.26100 58.03800 1.000 55.80398 ? 367 GLN A NE2 1 
ATOM   2731 N  N   . ASN A 1 374 ? 53.42500 -13.27000 51.27900 1.000 33.09583 ? 368 ASN A N   1 
ATOM   2732 C  CA  . ASN A 1 374 ? 53.77600 -14.14900 50.16400 1.000 32.85422 ? 368 ASN A CA  1 
ATOM   2733 C  C   . ASN A 1 374 ? 54.97400 -13.61000 49.39200 1.000 35.48731 ? 368 ASN A C   1 
ATOM   2734 O  O   . ASN A 1 374 ? 55.87500 -14.36700 49.01100 1.000 41.13453 ? 368 ASN A O   1 
ATOM   2735 C  CB  . ASN A 1 374 ? 52.60100 -14.31800 49.18600 1.000 32.32136 ? 368 ASN A CB  1 
ATOM   2736 C  CG  . ASN A 1 374 ? 51.37400 -14.97400 49.80100 1.000 34.81797 ? 368 ASN A CG  1 
ATOM   2737 O  OD1 . ASN A 1 374 ? 50.27700 -14.85700 49.25000 1.000 33.93340 ? 368 ASN A OD1 1 
ATOM   2738 N  ND2 . ASN A 1 374 ? 51.54200 -15.67100 50.91700 1.000 27.06023 ? 368 ASN A ND2 1 
ATOM   2739 N  N   . LEU A 1 375 ? 54.97700 -12.30800 49.12200 1.000 32.57500 ? 369 LEU A N   1 
ATOM   2740 C  CA  . LEU A 1 375 ? 55.94400 -11.67800 48.23700 1.000 37.86579 ? 369 LEU A CA  1 
ATOM   2741 C  C   . LEU A 1 375 ? 57.25600 -11.33300 48.93400 1.000 44.18166 ? 369 LEU A C   1 
ATOM   2742 O  O   . LEU A 1 375 ? 58.24200 -11.03700 48.24700 1.000 42.97393 ? 369 LEU A O   1 
ATOM   2743 C  CB  . LEU A 1 375 ? 55.31800 -10.41600 47.63700 1.000 38.34310 ? 369 LEU A CB  1 
ATOM   2744 C  CG  . LEU A 1 375 ? 54.11200 -10.67400 46.72500 1.000 38.66493 ? 369 LEU A CG  1 
ATOM   2745 C  CD1 . LEU A 1 375 ? 53.51400 -9.37200  46.20700 1.000 30.26274 ? 369 LEU A CD1 1 
ATOM   2746 C  CD2 . LEU A 1 375 ? 54.50300 -11.59800 45.56800 1.000 31.42825 ? 369 LEU A CD2 1 
ATOM   2747 N  N   . GLU A 1 376 ? 57.28200 -11.36400 50.27200 1.000 48.47270 ? 370 GLU A N   1 
ATOM   2748 C  CA  . GLU A 1 376 ? 58.50700 -11.07300 51.01000 1.000 53.32753 ? 370 GLU A CA  1 
ATOM   2749 C  C   . GLU A 1 376 ? 59.63800 -11.99500 50.57700 1.000 55.03616 ? 370 GLU A C   1 
ATOM   2750 O  O   . GLU A 1 376 ? 60.76500 -11.54300 50.35000 1.000 58.23167 ? 370 GLU A O   1 
ATOM   2751 C  CB  . GLU A 1 376 ? 58.25900 -11.20800 52.51700 1.000 53.85505 ? 370 GLU A CB  1 
ATOM   2752 C  CG  . GLU A 1 376 ? 57.89700 -9.90100  53.23000 1.000 61.60288 ? 370 GLU A CG  1 
ATOM   2753 C  CD  . GLU A 1 376 ? 57.15500 -10.13600 54.54700 1.000 63.20872 ? 370 GLU A CD  1 
ATOM   2754 O  OE1 . GLU A 1 376 ? 57.59100 -11.02400 55.31500 1.000 64.90091 ? 370 GLU A OE1 1 
ATOM   2755 O  OE2 . GLU A 1 376 ? 56.14700 -9.43500  54.82100 1.000 56.07406 ? 370 GLU A OE2 1 
ATOM   2756 N  N   . ASN A 1 377 ? 59.34800 -13.28600 50.42500 1.000 59.71247 ? 371 ASN A N   1 
ATOM   2757 C  CA  . ASN A 1 377 ? 60.37400 -14.29000 50.17900 1.000 63.46692 ? 371 ASN A CA  1 
ATOM   2758 C  C   . ASN A 1 377 ? 60.63300 -14.55800 48.70200 1.000 63.54306 ? 371 ASN A C   1 
ATOM   2759 O  O   . ASN A 1 377 ? 61.54800 -15.32600 48.38500 1.000 64.60488 ? 371 ASN A O   1 
ATOM   2760 C  CB  . ASN A 1 377 ? 59.99000 -15.61600 50.84800 1.000 66.14731 ? 371 ASN A CB  1 
ATOM   2761 C  CG  . ASN A 1 377 ? 59.31500 -15.42300 52.19400 1.000 67.58766 ? 371 ASN A CG  1 
ATOM   2762 O  OD1 . ASN A 1 377 ? 59.87900 -14.81600 53.10500 1.000 71.34769 ? 371 ASN A OD1 1 
ATOM   2763 N  ND2 . ASN A 1 377 ? 58.10600 -15.95600 52.33000 1.000 67.45965 ? 371 ASN A ND2 1 
ATOM   2764 N  N   . VAL A 1 378 ? 59.85700 -13.97700 47.79300 1.000 58.93962 ? 372 VAL A N   1 
ATOM   2765 C  CA  . VAL A 1 378 ? 59.98100 -14.37400 46.39200 1.000 55.55440 ? 372 VAL A CA  1 
ATOM   2766 C  C   . VAL A 1 378 ? 61.19000 -13.68300 45.77900 1.000 53.97442 ? 372 VAL A C   1 
ATOM   2767 O  O   . VAL A 1 378 ? 61.46100 -12.50900 46.07400 1.000 52.05530 ? 372 VAL A O   1 
ATOM   2768 C  CB  . VAL A 1 378 ? 58.70000 -14.08500 45.58400 1.000 51.72104 ? 372 VAL A CB  1 
ATOM   2769 C  CG1 . VAL A 1 378 ? 57.52100 -14.84400 46.16900 1.000 46.19570 ? 372 VAL A CG1 1 
ATOM   2770 C  CG2 . VAL A 1 378 ? 58.41100 -12.58200 45.49100 1.000 44.04154 ? 372 VAL A CG2 1 
ATOM   2771 N  N   . PRO A 1 379 ? 61.95300 -14.38900 44.95000 1.000 51.80629 ? 373 PRO A N   1 
ATOM   2772 C  CA  . PRO A 1 379 ? 63.00600 -13.73300 44.17200 1.000 52.13196 ? 373 PRO A CA  1 
ATOM   2773 C  C   . PRO A 1 379 ? 62.43200 -12.59100 43.35000 1.000 56.42656 ? 373 PRO A C   1 
ATOM   2774 O  O   . PRO A 1 379 ? 61.37700 -12.72500 42.72600 1.000 54.19133 ? 373 PRO A O   1 
ATOM   2775 C  CB  . PRO A 1 379 ? 63.52900 -14.85800 43.27500 1.000 51.94039 ? 373 PRO A CB  1 
ATOM   2776 C  CG  . PRO A 1 379 ? 63.21500 -16.11400 44.03600 1.000 54.16016 ? 373 PRO A CG  1 
ATOM   2777 C  CD  . PRO A 1 379 ? 61.91100 -15.84300 44.72300 1.000 51.47778 ? 373 PRO A CD  1 
ATOM   2778 N  N   . SER A 1 380 ? 63.13300 -11.45900 43.36200 1.000 44.82653 ? 374 SER A N   1 
ATOM   2779 C  CA  . SER A 1 380 ? 62.71700 -10.29900 42.59000 1.000 50.29895 ? 374 SER A CA  1 
ATOM   2780 C  C   . SER A 1 380 ? 62.88900 -10.56000 41.09100 1.000 52.93997 ? 374 SER A C   1 
ATOM   2781 O  O   . SER A 1 380 ? 63.39400 -11.60200 40.65600 1.000 52.66392 ? 374 SER A O   1 
ATOM   2782 C  CB  . SER A 1 380 ? 63.51000 -9.06400  43.01900 1.000 51.67302 ? 374 SER A CB  1 
ATOM   2783 O  OG  . SER A 1 380 ? 63.20500 -8.70800  44.35800 1.000 55.12278 ? 374 SER A OG  1 
ATOM   2784 N  N   . LEU A 1 381 ? 62.45900 -9.59000  40.28800 1.000 51.73857 ? 375 LEU A N   1 
ATOM   2785 C  CA  . LEU A 1 381 ? 62.59100 -9.71000  38.84200 1.000 48.97480 ? 375 LEU A CA  1 
ATOM   2786 C  C   . LEU A 1 381 ? 64.06500 -9.84600  38.46400 1.000 54.65783 ? 375 LEU A C   1 
ATOM   2787 O  O   . LEU A 1 381 ? 64.93500 -9.20500  39.06100 1.000 53.04150 ? 375 LEU A O   1 
ATOM   2788 C  CB  . LEU A 1 381 ? 61.97600 -8.48800  38.16200 1.000 51.13993 ? 375 LEU A CB  1 
ATOM   2789 C  CG  . LEU A 1 381 ? 60.44400 -8.43500  38.07900 1.000 54.13113 ? 375 LEU A CG  1 
ATOM   2790 C  CD1 . LEU A 1 381 ? 59.97700 -6.98400  38.02000 1.000 45.90958 ? 375 LEU A CD1 1 
ATOM   2791 C  CD2 . LEU A 1 381 ? 59.88900 -9.23400  36.90100 1.000 45.29853 ? 375 LEU A CD2 1 
ATOM   2792 N  N   . THR A 1 382 ? 64.33900 -10.69900 37.47500 1.000 57.90840 ? 376 THR A N   1 
ATOM   2793 C  CA  . THR A 1 382 ? 65.71000 -11.00100 37.06300 1.000 59.53885 ? 376 THR A CA  1 
ATOM   2794 C  C   . THR A 1 382 ? 66.46900 -9.73000  36.69000 1.000 58.64165 ? 376 THR A C   1 
ATOM   2795 O  O   . THR A 1 382 ? 66.00400 -8.94100  35.86300 1.000 54.72480 ? 376 THR A O   1 
ATOM   2796 C  CB  . THR A 1 382 ? 65.69000 -11.95900 35.86900 1.000 60.04185 ? 376 THR A CB  1 
ATOM   2797 O  OG1 . THR A 1 382 ? 65.50000 -13.30300 36.33000 1.000 60.60954 ? 376 THR A OG1 1 
ATOM   2798 C  CG2 . THR A 1 382 ? 66.99700 -11.86200 35.06500 1.000 56.84585 ? 376 THR A CG2 1 
ATOM   2799 N  N   . GLU A 1 383 ? 67.64500 -9.53900  37.29800 1.000 63.77769 ? 377 GLU A N   1 
ATOM   2800 C  CA  . GLU A 1 383 ? 68.46800 -8.36600  37.00800 1.000 59.09292 ? 377 GLU A CA  1 
ATOM   2801 C  C   . GLU A 1 383 ? 68.73300 -8.23900  35.51000 1.000 56.20361 ? 377 GLU A C   1 
ATOM   2802 O  O   . GLU A 1 383 ? 69.14200 -9.20300  34.85100 1.000 55.12378 ? 377 GLU A O   1 
ATOM   2803 C  CB  . GLU A 1 383 ? 69.79000 -8.44500  37.77500 1.000 49.69750 ? 377 GLU A CB  1 
ATOM   2804 N  N   . GLY A 1 384 ? 68.47300 -7.04800  34.97600 1.000 49.35865 ? 378 GLY A N   1 
ATOM   2805 C  CA  . GLY A 1 384 ? 68.65400 -6.77400  33.56500 1.000 53.06915 ? 378 GLY A CA  1 
ATOM   2806 C  C   . GLY A 1 384 ? 67.47400 -7.09800  32.67400 1.000 59.21883 ? 378 GLY A C   1 
ATOM   2807 O  O   . GLY A 1 384 ? 67.59900 -6.98600  31.44600 1.000 56.66126 ? 378 GLY A O   1 
ATOM   2808 N  N   . GLN A 1 385 ? 66.33700 -7.49700  33.24400 1.000 58.90858 ? 379 GLN A N   1 
ATOM   2809 C  CA  . GLN A 1 385 ? 65.17400 -7.85800  32.44400 1.000 57.30621 ? 379 GLN A CA  1 
ATOM   2810 C  C   . GLN A 1 385 ? 64.59000 -6.62700  31.75200 1.000 55.07725 ? 379 GLN A C   1 
ATOM   2811 O  O   . GLN A 1 385 ? 64.59600 -5.52300  32.30400 1.000 54.12428 ? 379 GLN A O   1 
ATOM   2812 C  CB  . GLN A 1 385 ? 64.11100 -8.51900  33.32500 1.000 55.24843 ? 379 GLN A CB  1 
ATOM   2813 C  CG  . GLN A 1 385 ? 63.62400 -7.63600  34.47200 1.000 56.75629 ? 379 GLN A CG  1 
ATOM   2814 C  CD  . GLN A 1 385 ? 62.43200 -6.79000  34.07000 1.000 54.73569 ? 379 GLN A CD  1 
ATOM   2815 O  OE1 . GLN A 1 385 ? 61.75700 -7.08400  33.08100 1.000 49.89454 ? 379 GLN A OE1 1 
ATOM   2816 N  NE2 . GLN A 1 385 ? 62.17800 -5.72700  34.82100 1.000 55.59713 ? 379 GLN A NE2 1 
ATOM   2817 N  N   . GLU A 1 386 ? 64.07500 -6.82400  30.53700 1.000 58.82632 ? 380 GLU A N   1 
ATOM   2818 C  CA  . GLU A 1 386 ? 63.51500 -5.73500  29.74400 1.000 61.15438 ? 380 GLU A CA  1 
ATOM   2819 C  C   . GLU A 1 386 ? 62.01300 -5.87600  29.53100 1.000 64.27079 ? 380 GLU A C   1 
ATOM   2820 O  O   . GLU A 1 386 ? 61.42500 -5.08500  28.78400 1.000 65.03650 ? 380 GLU A O   1 
ATOM   2821 C  CB  . GLU A 1 386 ? 64.22900 -5.63800  28.39200 1.000 64.73475 ? 380 GLU A CB  1 
ATOM   2822 C  CG  . GLU A 1 386 ? 65.73600 -5.85700  28.47400 1.000 69.00765 ? 380 GLU A CG  1 
ATOM   2823 C  CD  . GLU A 1 386 ? 66.47300 -5.38500  27.23200 1.000 74.78225 ? 380 GLU A CD  1 
ATOM   2824 O  OE1 . GLU A 1 386 ? 65.99000 -5.64900  26.10700 1.000 76.78594 ? 380 GLU A OE1 1 
ATOM   2825 O  OE2 . GLU A 1 386 ? 67.54000 -4.75100  27.38600 1.000 67.94432 ? 380 GLU A OE2 1 
ATOM   2826 N  N   . ILE A 1 387 ? 61.37600 -6.86100  30.16500 1.000 59.79849 ? 381 ILE A N   1 
ATOM   2827 C  CA  . ILE A 1 387 ? 59.93800 -7.03300  29.99100 1.000 60.48051 ? 381 ILE A CA  1 
ATOM   2828 C  C   . ILE A 1 387 ? 59.16500 -6.02500  30.83300 1.000 55.07586 ? 381 ILE A C   1 
ATOM   2829 O  O   . ILE A 1 387 ? 58.28200 -5.31800  30.33000 1.000 56.55492 ? 381 ILE A O   1 
ATOM   2830 C  CB  . ILE A 1 387 ? 59.52200 -8.47700  30.31800 1.000 57.06683 ? 381 ILE A CB  1 
ATOM   2831 C  CG1 . ILE A 1 387 ? 60.38400 -9.46800  29.53400 1.000 56.24718 ? 381 ILE A CG1 1 
ATOM   2832 C  CG2 . ILE A 1 387 ? 58.05600 -8.67200  29.99100 1.000 56.04993 ? 381 ILE A CG2 1 
ATOM   2833 C  CD1 . ILE A 1 387 ? 60.36600 -10.87900 30.09500 1.000 56.52911 ? 381 ILE A CD1 1 
ATOM   2834 N  N   . ILE A 1 388 ? 59.48000 -5.93700  32.12200 1.000 51.82724 ? 382 ILE A N   1 
ATOM   2835 C  CA  . ILE A 1 388 ? 58.77900 -5.03500  33.03000 1.000 57.25089 ? 382 ILE A CA  1 
ATOM   2836 C  C   . ILE A 1 388 ? 59.56600 -3.72800  33.10400 1.000 58.72136 ? 382 ILE A C   1 
ATOM   2837 O  O   . ILE A 1 388 ? 60.64700 -3.66700  33.70000 1.000 51.39091 ? 382 ILE A O   1 
ATOM   2838 C  CB  . ILE A 1 388 ? 58.59000 -5.65900  34.41900 1.000 52.94821 ? 382 ILE A CB  1 
ATOM   2839 C  CG1 . ILE A 1 388 ? 57.96400 -7.05600  34.31100 1.000 52.18346 ? 382 ILE A CG1 1 
ATOM   2840 C  CG2 . ILE A 1 388 ? 57.71500 -4.75000  35.28700 1.000 49.29672 ? 382 ILE A CG2 1 
ATOM   2841 C  CD1 . ILE A 1 388 ? 56.61900 -7.09000  33.58400 1.000 52.45080 ? 382 ILE A CD1 1 
ATOM   2842 N  N   . ARG A 1 389 ? 59.01700 -2.67900  32.49800 1.000 56.11914 ? 383 ARG A N   1 
ATOM   2843 C  CA  . ARG A 1 389 ? 59.68100 -1.39100  32.45300 1.000 61.12395 ? 383 ARG A CA  1 
ATOM   2844 C  C   . ARG A 1 389 ? 59.73500 -0.75900  33.84200 1.000 62.65984 ? 383 ARG A C   1 
ATOM   2845 O  O   . ARG A 1 389 ? 58.90500 -1.05800  34.70500 1.000 62.60630 ? 383 ARG A O   1 
ATOM   2846 C  CB  . ARG A 1 389 ? 58.95100 -0.45900  31.48900 1.000 60.78445 ? 383 ARG A CB  1 
ATOM   2847 C  CG  . ARG A 1 389 ? 59.12600 -0.82500  30.02900 1.000 62.25363 ? 383 ARG A CG  1 
ATOM   2848 C  CD  . ARG A 1 389 ? 60.33900 -0.13700  29.42400 1.000 62.44178 ? 383 ARG A CD  1 
ATOM   2849 N  NE  . ARG A 1 389 ? 60.26200 -0.15200  27.96900 1.000 66.04852 ? 383 ARG A NE  1 
ATOM   2850 C  CZ  . ARG A 1 389 ? 59.66900 0.78200   27.23900 1.000 59.29349 ? 383 ARG A CZ  1 
ATOM   2851 N  NH1 . ARG A 1 389 ? 59.13700 1.86000   27.79400 1.000 60.25490 ? 383 ARG A NH1 1 
ATOM   2852 N  NH2 . ARG A 1 389 ? 59.60900 0.63000   25.91900 1.000 60.28411 ? 383 ARG A NH2 1 
ATOM   2853 N  N   . PRO A 1 390 ? 60.70800 0.12100   34.08400 1.000 64.47708 ? 384 PRO A N   1 
ATOM   2854 C  CA  . PRO A 1 390 ? 60.68700 0.91400   35.31700 1.000 61.07891 ? 384 PRO A CA  1 
ATOM   2855 C  C   . PRO A 1 390 ? 59.51800 1.89100   35.31300 1.000 62.45899 ? 384 PRO A C   1 
ATOM   2856 O  O   . PRO A 1 390 ? 58.94700 2.21900   34.27000 1.000 63.48059 ? 384 PRO A O   1 
ATOM   2857 C  CB  . PRO A 1 390 ? 62.02900 1.65300   35.29400 1.000 62.32356 ? 384 PRO A CB  1 
ATOM   2858 C  CG  . PRO A 1 390 ? 62.41200 1.69600   33.84200 1.000 63.16308 ? 384 PRO A CG  1 
ATOM   2859 C  CD  . PRO A 1 390 ? 61.88900 0.41800   33.25100 1.000 61.60714 ? 384 PRO A CD  1 
ATOM   2860 N  N   . LEU A 1 391 ? 59.15800 2.35200   36.51400 1.000 66.88022 ? 385 LEU A N   1 
ATOM   2861 C  CA  . LEU A 1 391 ? 58.12600 3.37900   36.63200 1.000 64.64832 ? 385 LEU A CA  1 
ATOM   2862 C  C   . LEU A 1 391 ? 58.56100 4.68100   35.96800 1.000 69.06150 ? 385 LEU A C   1 
ATOM   2863 O  O   . LEU A 1 391 ? 57.71500 5.47300   35.53200 1.000 68.69533 ? 385 LEU A O   1 
ATOM   2864 C  CB  . LEU A 1 391 ? 57.78600 3.60700   38.10600 1.000 59.70921 ? 385 LEU A CB  1 
ATOM   2865 C  CG  . LEU A 1 391 ? 56.62800 4.55000   38.43700 1.000 68.38180 ? 385 LEU A CG  1 
ATOM   2866 C  CD1 . LEU A 1 391 ? 55.32100 3.77100   38.54500 1.000 67.12260 ? 385 LEU A CD1 1 
ATOM   2867 C  CD2 . LEU A 1 391 ? 56.90700 5.32300   39.72400 1.000 63.43757 ? 385 LEU A CD2 1 
ATOM   2868 N  N   . SER A 1 392 ? 59.87500 4.91100   35.87100 1.000 69.73362 ? 386 SER A N   1 
ATOM   2869 C  CA  . SER A 1 392 ? 60.39800 6.10100   35.20900 1.000 70.66354 ? 386 SER A CA  1 
ATOM   2870 C  C   . SER A 1 392 ? 60.26400 6.03200   33.68900 1.000 68.35820 ? 386 SER A C   1 
ATOM   2871 O  O   . SER A 1 392 ? 60.24900 7.07900   33.03100 1.000 70.02516 ? 386 SER A O   1 
ATOM   2872 C  CB  . SER A 1 392 ? 61.86900 6.31400   35.59700 1.000 66.69320 ? 386 SER A CB  1 
ATOM   2873 O  OG  . SER A 1 392 ? 62.72800 5.43300   34.88600 1.000 68.68524 ? 386 SER A OG  1 
ATOM   2874 N  N   . ASN A 1 393 ? 60.16700 4.83400   33.11500 1.000 67.33782 ? 387 ASN A N   1 
ATOM   2875 C  CA  . ASN A 1 393 ? 60.07100 4.65300   31.66700 1.000 62.40168 ? 387 ASN A CA  1 
ATOM   2876 C  C   . ASN A 1 393 ? 58.96000 3.65800   31.33900 1.000 58.07125 ? 387 ASN A C   1 
ATOM   2877 O  O   . ASN A 1 393 ? 59.22300 2.55800   30.84100 1.000 57.32975 ? 387 ASN A O   1 
ATOM   2878 C  CB  . ASN A 1 393 ? 61.41300 4.19200   31.09300 1.000 55.84260 ? 387 ASN A CB  1 
ATOM   2879 C  CG  . ASN A 1 393 ? 61.44500 4.24000   29.57600 1.000 61.33880 ? 387 ASN A CG  1 
ATOM   2880 O  OD1 . ASN A 1 393 ? 60.93300 5.18100   28.96200 1.000 58.44524 ? 387 ASN A OD1 1 
ATOM   2881 N  ND2 . ASN A 1 393 ? 62.05000 3.22400   28.96300 1.000 53.78310 ? 387 ASN A ND2 1 
ATOM   2882 N  N   . PRO A 1 394 ? 57.70300 4.02200   31.58500 1.000 58.81412 ? 388 PRO A N   1 
ATOM   2883 C  CA  . PRO A 1 394 ? 56.59600 3.11800   31.25600 1.000 58.79675 ? 388 PRO A CA  1 
ATOM   2884 C  C   . PRO A 1 394 ? 56.29200 3.12200   29.76400 1.000 59.25581 ? 388 PRO A C   1 
ATOM   2885 O  O   . PRO A 1 394 ? 56.62200 4.06300   29.03800 1.000 58.97292 ? 388 PRO A O   1 
ATOM   2886 C  CB  . PRO A 1 394 ? 55.42100 3.69500   32.05300 1.000 55.40112 ? 388 PRO A CB  1 
ATOM   2887 C  CG  . PRO A 1 394 ? 55.71300 5.15700   32.13100 1.000 60.15397 ? 388 PRO A CG  1 
ATOM   2888 C  CD  . PRO A 1 394 ? 57.22200 5.31100   32.11500 1.000 59.23823 ? 388 PRO A CD  1 
ATOM   2889 N  N   . ILE A 1 395 ? 55.64900 2.03600   29.31400 1.000 54.85112 ? 389 ILE A N   1 
ATOM   2890 C  CA  . ILE A 1 395 ? 55.14800 1.98400   27.94100 1.000 53.60702 ? 389 ILE A CA  1 
ATOM   2891 C  C   . ILE A 1 395 ? 54.02400 2.99600   27.74000 1.000 50.00945 ? 389 ILE A C   1 
ATOM   2892 O  O   . ILE A 1 395 ? 53.89700 3.59800   26.66700 1.000 46.65127 ? 389 ILE A O   1 
ATOM   2893 C  CB  . ILE A 1 395 ? 54.70100 0.55500   27.58200 1.000 50.89618 ? 389 ILE A CB  1 
ATOM   2894 C  CG1 . ILE A 1 395 ? 55.81400 -0.45200  27.90200 1.000 54.45243 ? 389 ILE A CG1 1 
ATOM   2895 C  CG2 . ILE A 1 395 ? 54.26700 0.48200   26.12400 1.000 48.20502 ? 389 ILE A CG2 1 
ATOM   2896 C  CD1 . ILE A 1 395 ? 55.54800 -1.86600  27.39300 1.000 48.55777 ? 389 ILE A CD1 1 
ATOM   2897 N  N   . LYS A 1 396 ? 53.19600 3.20500   28.76300 1.000 50.34651 ? 390 LYS A N   1 
ATOM   2898 C  CA  . LYS A 1 396 ? 52.20000 4.26700   28.75300 1.000 50.91883 ? 390 LYS A CA  1 
ATOM   2899 C  C   . LYS A 1 396 ? 52.06500 4.82400   30.16400 1.000 53.50706 ? 390 LYS A C   1 
ATOM   2900 O  O   . LYS A 1 396 ? 52.13100 4.07300   31.14300 1.000 48.76304 ? 390 LYS A O   1 
ATOM   2901 C  CB  . LYS A 1 396 ? 50.84500 3.76600   28.23100 1.000 46.57464 ? 390 LYS A CB  1 
ATOM   2902 C  CG  . LYS A 1 396 ? 49.87100 4.86300   27.82300 1.000 51.44573 ? 390 LYS A CG  1 
ATOM   2903 C  CD  . LYS A 1 396 ? 48.46800 4.29000   27.59900 1.000 50.85462 ? 390 LYS A CD  1 
ATOM   2904 C  CE  . LYS A 1 396 ? 47.46200 5.38800   27.29400 1.000 49.44206 ? 390 LYS A CE  1 
ATOM   2905 N  NZ  . LYS A 1 396 ? 46.48100 5.58900   28.40000 1.000 52.79664 ? 390 LYS A NZ  1 
ATOM   2906 N  N   . GLU A 1 397 ? 51.87900 6.14700   30.25800 1.000 52.49832 ? 391 GLU A N   1 
ATOM   2907 C  CA  . GLU A 1 397 ? 51.85400 6.81000   31.56200 1.000 55.55941 ? 391 GLU A CA  1 
ATOM   2908 C  C   . GLU A 1 397 ? 50.68700 6.33500   32.42000 1.000 55.62874 ? 391 GLU A C   1 
ATOM   2909 O  O   . GLU A 1 397 ? 50.79300 6.30100   33.65200 1.000 52.95399 ? 391 GLU A O   1 
ATOM   2910 C  CB  . GLU A 1 397 ? 51.78600 8.32700   31.38400 1.000 53.85373 ? 391 GLU A CB  1 
ATOM   2911 C  CG  . GLU A 1 397 ? 52.75400 9.09700   32.26300 1.000 62.46045 ? 391 GLU A CG  1 
ATOM   2912 C  CD  . GLU A 1 397 ? 54.18600 8.98500   31.77800 1.000 71.74500 ? 391 GLU A CD  1 
ATOM   2913 O  OE1 . GLU A 1 397 ? 54.45500 9.37400   30.62000 1.000 72.87030 ? 391 GLU A OE1 1 
ATOM   2914 O  OE2 . GLU A 1 397 ? 55.04300 8.50500   32.55300 1.000 74.45384 ? 391 GLU A OE2 1 
ATOM   2915 N  N   . THR A 1 398 ? 49.56800 5.99500   31.79500 1.000 53.07021 ? 392 THR A N   1 
ATOM   2916 C  CA  . THR A 1 398 ? 48.40900 5.41500   32.45400 1.000 48.19211 ? 392 THR A CA  1 
ATOM   2917 C  C   . THR A 1 398 ? 48.08400 4.08200   31.78600 1.000 47.21465 ? 392 THR A C   1 
ATOM   2918 O  O   . THR A 1 398 ? 48.78900 3.62400   30.88100 1.000 51.00769 ? 392 THR A O   1 
ATOM   2919 C  CB  . THR A 1 398 ? 47.20400 6.36400   32.39400 1.000 40.90826 ? 392 THR A CB  1 
ATOM   2920 O  OG1 . THR A 1 398 ? 46.74200 6.46500   31.03800 1.000 48.66511 ? 392 THR A OG1 1 
ATOM   2921 C  CG2 . THR A 1 398 ? 47.58100 7.75400   32.90100 1.000 47.23354 ? 392 THR A CG2 1 
ATOM   2922 N  N   . GLY A 1 399 ? 46.99700 3.45900   32.23400 1.000 41.74083 ? 393 GLY A N   1 
ATOM   2923 C  CA  . GLY A 1 399 ? 46.62600 2.16400   31.70200 1.000 43.30176 ? 393 GLY A CA  1 
ATOM   2924 C  C   . GLY A 1 399 ? 46.03400 2.22300   30.29700 1.000 44.05878 ? 393 GLY A C   1 
ATOM   2925 O  O   . GLY A 1 399 ? 45.58700 3.26000   29.79900 1.000 37.59256 ? 393 GLY A O   1 
ATOM   2926 N  N   . HIS A 1 400 ? 46.03300 1.05400   29.65600 1.000 39.96582 ? 394 HIS A N   1 
ATOM   2927 C  CA  . HIS A 1 400 ? 45.44200 0.91300   28.33200 1.000 40.91184 ? 394 HIS A CA  1 
ATOM   2928 C  C   . HIS A 1 400 ? 43.93400 1.04500   28.36400 1.000 36.01943 ? 394 HIS A C   1 
ATOM   2929 O  O   . HIS A 1 400 ? 43.33800 1.49700   27.38500 1.000 35.37941 ? 394 HIS A O   1 
ATOM   2930 C  CB  . HIS A 1 400 ? 45.79400 -0.44600  27.74700 1.000 43.44322 ? 394 HIS A CB  1 
ATOM   2931 C  CG  . HIS A 1 400 ? 47.02200 -0.43500  26.90300 1.000 49.42897 ? 394 HIS A CG  1 
ATOM   2932 N  ND1 . HIS A 1 400 ? 47.43000 -1.53100  26.17400 1.000 47.79635 ? 394 HIS A ND1 1 
ATOM   2933 C  CD2 . HIS A 1 400 ? 47.92900 0.54100   26.66200 1.000 47.91737 ? 394 HIS A CD2 1 
ATOM   2934 C  CE1 . HIS A 1 400 ? 48.54000 -1.23300  25.52400 1.000 51.30751 ? 394 HIS A CE1 1 
ATOM   2935 N  NE2 . HIS A 1 400 ? 48.86600 0.01700   25.80500 1.000 53.70347 ? 394 HIS A NE2 1 
ATOM   2936 N  N   . ILE A 1 401 ? 43.30000 0.60300   29.45000 1.000 34.45351 ? 395 ILE A N   1 
ATOM   2937 C  CA  . ILE A 1 401 ? 41.84800 0.52700   29.49000 1.000 33.89237 ? 395 ILE A CA  1 
ATOM   2938 C  C   . ILE A 1 401 ? 41.26800 1.91900   29.68000 1.000 31.74300 ? 395 ILE A C   1 
ATOM   2939 O  O   . ILE A 1 401 ? 41.70300 2.67900   30.55200 1.000 31.77896 ? 395 ILE A O   1 
ATOM   2940 C  CB  . ILE A 1 401 ? 41.39700 -0.43600  30.59200 1.000 34.00936 ? 395 ILE A CB  1 
ATOM   2941 C  CG1 . ILE A 1 401 ? 41.68500 -1.88000  30.14400 1.000 35.27750 ? 395 ILE A CG1 1 
ATOM   2942 C  CG2 . ILE A 1 401 ? 39.91100 -0.22100  30.91600 1.000 31.99102 ? 395 ILE A CG2 1 
ATOM   2943 C  CD1 . ILE A 1 401 ? 41.37100 -2.92500  31.19700 1.000 37.87053 ? 395 ILE A CD1 1 
ATOM   2944 N  N   . GLN A 1 402 ? 40.26700 2.25400   28.87200 1.000 31.62276 ? 396 GLN A N   1 
ATOM   2945 C  CA  . GLN A 1 402 ? 39.69500 3.59000   28.86300 1.000 33.50356 ? 396 GLN A CA  1 
ATOM   2946 C  C   . GLN A 1 402 ? 38.18200 3.45800   28.80300 1.000 29.74613 ? 396 GLN A C   1 
ATOM   2947 O  O   . GLN A 1 402 ? 37.66000 2.67200   28.00500 1.000 24.70751 ? 396 GLN A O   1 
ATOM   2948 C  CB  . GLN A 1 402 ? 40.23800 4.36800   27.65600 1.000 31.58188 ? 396 GLN A CB  1 
ATOM   2949 C  CG  . GLN A 1 402 ? 39.78800 5.79400   27.50600 1.000 40.98525 ? 396 GLN A CG  1 
ATOM   2950 C  CD  . GLN A 1 402 ? 40.22100 6.62500   28.68600 1.000 39.29907 ? 396 GLN A CD  1 
ATOM   2951 O  OE1 . GLN A 1 402 ? 41.37900 6.56900   29.10300 1.000 39.92331 ? 396 GLN A OE1 1 
ATOM   2952 N  NE2 . GLN A 1 402 ? 39.31800 7.45500   29.18400 1.000 31.89202 ? 396 GLN A NE2 1 
ATOM   2953 N  N   . ILE A 1 403 ? 37.48500 4.21200   29.64400 1.000 24.44253 ? 397 ILE A N   1 
ATOM   2954 C  CA  . ILE A 1 403 ? 36.03100 4.19200   29.71400 1.000 27.25216 ? 397 ILE A CA  1 
ATOM   2955 C  C   . ILE A 1 403 ? 35.49900 5.40100   28.96100 1.000 31.96700 ? 397 ILE A C   1 
ATOM   2956 O  O   . ILE A 1 403 ? 35.79700 6.54300   29.32600 1.000 31.13286 ? 397 ILE A O   1 
ATOM   2957 C  CB  . ILE A 1 403 ? 35.53400 4.20600   31.16700 1.000 24.66675 ? 397 ILE A CB  1 
ATOM   2958 C  CG1 . ILE A 1 403 ? 36.12200 3.02600   31.95900 1.000 27.67984 ? 397 ILE A CG1 1 
ATOM   2959 C  CG2 . ILE A 1 403 ? 34.01300 4.25500   31.20500 1.000 29.65132 ? 397 ILE A CG2 1 
ATOM   2960 C  CD1 . ILE A 1 403 ? 35.92300 1.65300   31.28500 1.000 24.28230 ? 397 ILE A CD1 1 
ATOM   2961 N  N   . LEU A 1 404 ? 34.68900 5.18200   27.93500 1.000 27.18994 ? 398 LEU A N   1 
ATOM   2962 C  CA  . LEU A 1 404 ? 34.14100 6.29000   27.16800 1.000 26.82596 ? 398 LEU A CA  1 
ATOM   2963 C  C   . LEU A 1 404 ? 32.63700 6.37600   27.36300 1.000 29.29621 ? 398 LEU A C   1 
ATOM   2964 O  O   . LEU A 1 404 ? 31.93600 5.35700   27.33700 1.000 28.17606 ? 398 LEU A O   1 
ATOM   2965 C  CB  . LEU A 1 404 ? 34.46200 6.14000   25.67600 1.000 21.21490 ? 398 LEU A CB  1 
ATOM   2966 C  CG  . LEU A 1 404 ? 35.93000 5.84200   25.42900 1.000 29.30679 ? 398 LEU A CG  1 
ATOM   2967 C  CD1 . LEU A 1 404 ? 36.18000 5.49600   23.94400 1.000 33.50744 ? 398 LEU A CD1 1 
ATOM   2968 C  CD2 . LEU A 1 404 ? 36.75400 7.03700   25.89200 1.000 29.77455 ? 398 LEU A CD2 1 
ATOM   2969 N  N   . ARG A 1 405 ? 32.14500 7.60000   27.53800 1.000 27.29952 ? 399 ARG A N   1 
ATOM   2970 C  CA  . ARG A 1 405 ? 30.71200 7.83300   27.55700 1.000 25.58567 ? 399 ARG A CA  1 
ATOM   2971 C  C   . ARG A 1 405 ? 30.35500 8.74900   26.39500 1.000 30.72385 ? 399 ARG A C   1 
ATOM   2972 O  O   . ARG A 1 405 ? 30.75000 8.47500   25.25800 1.000 30.15641 ? 399 ARG A O   1 
ATOM   2973 C  CB  . ARG A 1 405 ? 30.28400 8.40500   28.91100 1.000 30.12762 ? 399 ARG A CB  1 
ATOM   2974 C  CG  . ARG A 1 405 ? 30.39200 7.36900   30.03700 1.000 31.17814 ? 399 ARG A CG  1 
ATOM   2975 C  CD  . ARG A 1 405 ? 29.79200 7.87700   31.35200 1.000 36.60603 ? 399 ARG A CD  1 
ATOM   2976 N  NE  . ARG A 1 405 ? 29.54100 6.78400   32.28600 1.000 42.73114 ? 399 ARG A NE  1 
ATOM   2977 C  CZ  . ARG A 1 405 ? 30.47300 6.25700   33.06500 1.000 39.63110 ? 399 ARG A CZ  1 
ATOM   2978 N  NH1 . ARG A 1 405 ? 31.71200 6.72300   33.06500 1.000 38.42238 ? 399 ARG A NH1 1 
ATOM   2979 N  NH2 . ARG A 1 405 ? 30.15200 5.25200   33.87600 1.000 40.62763 ? 399 ARG A NH2 1 
ATOM   2980 N  N   . GLY A 1 406 ? 29.62900 9.83800   26.65300 1.000 35.46009 ? 400 GLY A N   1 
ATOM   2981 C  CA  . GLY A 1 406 ? 29.20800 10.72100  25.58400 1.000 29.39720 ? 400 GLY A CA  1 
ATOM   2982 C  C   . GLY A 1 406 ? 27.83700 10.36200  25.05200 1.000 32.67559 ? 400 GLY A C   1 
ATOM   2983 O  O   . GLY A 1 406 ? 27.12300 9.51100   25.59600 1.000 30.16848 ? 400 GLY A O   1 
ATOM   2984 N  N   . ASP A 1 407 ? 27.46400 11.05200  23.96000 1.000 29.71084 ? 401 ASP A N   1 
ATOM   2985 C  CA  . ASP A 1 407 ? 26.11700 10.94000  23.39400 1.000 29.81973 ? 401 ASP A CA  1 
ATOM   2986 C  C   . ASP A 1 407 ? 25.75600 9.50100   23.04900 1.000 28.53129 ? 401 ASP A C   1 
ATOM   2987 O  O   . ASP A 1 407 ? 24.60100 9.09100   23.21400 1.000 29.03208 ? 401 ASP A O   1 
ATOM   2988 C  CB  . ASP A 1 407 ? 25.98000 11.76200  22.10800 1.000 26.62615 ? 401 ASP A CB  1 
ATOM   2989 C  CG  . ASP A 1 407 ? 26.25500 13.25400  22.30000 1.000 35.67669 ? 401 ASP A CG  1 
ATOM   2990 O  OD1 . ASP A 1 407 ? 26.07300 13.78500  23.42200 1.000 30.52047 ? 401 ASP A OD1 1 
ATOM   2991 O  OD2 . ASP A 1 407 ? 26.61100 13.88800  21.28700 1.000 34.79086 ? 401 ASP A OD2 1 
ATOM   2992 N  N   . LEU A 1 408 ? 26.69800 8.75800   22.47000 1.000 24.16309 ? 402 LEU A N   1 
ATOM   2993 C  CA  . LEU A 1 408 ? 26.38100 7.46700   21.87300 1.000 27.93304 ? 402 LEU A CA  1 
ATOM   2994 C  C   . LEU A 1 408 ? 26.65700 6.29600   22.80000 1.000 28.08996 ? 402 LEU A C   1 
ATOM   2995 O  O   . LEU A 1 408 ? 26.27100 5.16000   22.47600 1.000 29.64281 ? 402 LEU A O   1 
ATOM   2996 C  CB  . LEU A 1 408 ? 27.16300 7.27300   20.56600 1.000 23.66523 ? 402 LEU A CB  1 
ATOM   2997 C  CG  . LEU A 1 408 ? 26.85900 8.32700   19.51000 1.000 27.00968 ? 402 LEU A CG  1 
ATOM   2998 C  CD1 . LEU A 1 408 ? 27.69100 8.04600   18.25000 1.000 26.15893 ? 402 LEU A CD1 1 
ATOM   2999 C  CD2 . LEU A 1 408 ? 25.35600 8.36500   19.19800 1.000 23.16085 ? 402 LEU A CD2 1 
ATOM   3000 N  N   . ALA A 1 409 ? 27.30900 6.53700   23.93500 1.000 23.86814 ? 403 ALA A N   1 
ATOM   3001 C  CA  . ALA A 1 409 ? 27.54900 5.49900   24.93500 1.000 29.08921 ? 403 ALA A CA  1 
ATOM   3002 C  C   . ALA A 1 409 ? 27.26900 6.08900   26.31100 1.000 27.27542 ? 403 ALA A C   1 
ATOM   3003 O  O   . ALA A 1 409 ? 28.14800 6.14900   27.17900 1.000 27.66942 ? 403 ALA A O   1 
ATOM   3004 C  CB  . ALA A 1 409 ? 28.97300 4.94900   24.82500 1.000 27.86865 ? 403 ALA A CB  1 
ATOM   3005 N  N   . PRO A 1 410 ? 26.03400 6.53300   26.54200 1.000 25.44650 ? 404 PRO A N   1 
ATOM   3006 C  CA  . PRO A 1 410 ? 25.73900 7.22500   27.80300 1.000 31.16398 ? 404 PRO A CA  1 
ATOM   3007 C  C   . PRO A 1 410 ? 25.98800 6.36600   29.03400 1.000 31.16357 ? 404 PRO A C   1 
ATOM   3008 O  O   . PRO A 1 410 ? 26.40500 6.90000   30.07500 1.000 25.49845 ? 404 PRO A O   1 
ATOM   3009 C  CB  . PRO A 1 410 ? 24.25800 7.60900   27.65000 1.000 31.35654 ? 404 PRO A CB  1 
ATOM   3010 C  CG  . PRO A 1 410 ? 23.71500 6.68900   26.61200 1.000 27.55968 ? 404 PRO A CG  1 
ATOM   3011 C  CD  . PRO A 1 410 ? 24.84200 6.40100   25.68400 1.000 27.13500 ? 404 PRO A CD  1 
ATOM   3012 N  N   . ASP A 1 411 ? 25.78500 5.04900   28.94600 1.000 26.57416 ? 405 ASP A N   1 
ATOM   3013 C  CA  . ASP A 1 411 ? 26.00300 4.16900   30.09200 1.000 28.58889 ? 405 ASP A CA  1 
ATOM   3014 C  C   . ASP A 1 411 ? 27.38100 3.52800   30.08400 1.000 29.63360 ? 405 ASP A C   1 
ATOM   3015 O  O   . ASP A 1 411 ? 27.64700 2.64500   30.90900 1.000 27.16969 ? 405 ASP A O   1 
ATOM   3016 C  CB  . ASP A 1 411 ? 24.92100 3.08700   30.15700 1.000 30.46247 ? 405 ASP A CB  1 
ATOM   3017 C  CG  . ASP A 1 411 ? 23.56600 3.65200   30.53000 1.000 33.66071 ? 405 ASP A CG  1 
ATOM   3018 O  OD1 . ASP A 1 411 ? 23.51900 4.77900   31.05900 1.000 32.21780 ? 405 ASP A OD1 1 
ATOM   3019 O  OD2 . ASP A 1 411 ? 22.55100 2.98100   30.26900 1.000 33.19617 ? 405 ASP A OD2 1 
ATOM   3020 N  N   . GLY A 1 412 ? 28.25400 3.94600   29.18300 1.000 25.07605 ? 406 GLY A N   1 
ATOM   3021 C  CA  . GLY A 1 412 ? 29.64000 3.54000   29.22300 1.000 28.71654 ? 406 GLY A CA  1 
ATOM   3022 C  C   . GLY A 1 412 ? 30.00200 2.65700   28.04400 1.000 23.66044 ? 406 GLY A C   1 
ATOM   3023 O  O   . GLY A 1 412 ? 29.15200 2.13900   27.32100 1.000 24.37625 ? 406 GLY A O   1 
ATOM   3024 N  N   . SER A 1 413 ? 31.30800 2.49000   27.88700 1.000 23.81544 ? 407 SER A N   1 
ATOM   3025 C  CA  . SER A 1 413 ? 31.93000 1.71000   26.83100 1.000 24.37301 ? 407 SER A CA  1 
ATOM   3026 C  C   . SER A 1 413 ? 33.38700 1.52200   27.22900 1.000 23.29404 ? 407 SER A C   1 
ATOM   3027 O  O   . SER A 1 413 ? 33.89600 2.22300   28.10100 1.000 24.00934 ? 407 SER A O   1 
ATOM   3028 C  CB  . SER A 1 413 ? 31.80300 2.40500   25.46500 1.000 26.01267 ? 407 SER A CB  1 
ATOM   3029 O  OG  . SER A 1 413 ? 32.63800 3.55800   25.41200 1.000 27.81038 ? 407 SER A OG  1 
ATOM   3030 N  N   . VAL A 1 414 ? 34.06000 0.57900   26.58400 1.000 22.45612 ? 408 VAL A N   1 
ATOM   3031 C  CA  . VAL A 1 414 ? 35.41300 0.20400   26.98100 1.000 25.05837 ? 408 VAL A CA  1 
ATOM   3032 C  C   . VAL A 1 414 ? 36.29500 0.14400   25.74800 1.000 24.94013 ? 408 VAL A C   1 
ATOM   3033 O  O   . VAL A 1 414 ? 35.93200 -0.49800  24.75700 1.000 25.67116 ? 408 VAL A O   1 
ATOM   3034 C  CB  . VAL A 1 414 ? 35.45500 -1.15500  27.70700 1.000 22.63672 ? 408 VAL A CB  1 
ATOM   3035 C  CG1 . VAL A 1 414 ? 36.89500 -1.49700  28.05900 1.000 23.65378 ? 408 VAL A CG1 1 
ATOM   3036 C  CG2 . VAL A 1 414 ? 34.55500 -1.11800  28.96900 1.000 22.76447 ? 408 VAL A CG2 1 
ATOM   3037 N  N   . ALA A 1 415 ? 37.47600 0.75700   25.83200 1.000 27.86817 ? 409 ALA A N   1 
ATOM   3038 C  CA  . ALA A 1 415 ? 38.43100 0.73800   24.73900 1.000 25.23104 ? 409 ALA A CA  1 
ATOM   3039 C  C   . ALA A 1 415 ? 39.82300 0.47700   25.28300 1.000 27.13780 ? 409 ALA A C   1 
ATOM   3040 O  O   . ALA A 1 415 ? 40.15400 0.85900   26.40700 1.000 30.66228 ? 409 ALA A O   1 
ATOM   3041 C  CB  . ALA A 1 415 ? 38.43600 2.06100   23.94600 1.000 28.71748 ? 409 ALA A CB  1 
ATOM   3042 N  N   . LYS A 1 416 ? 40.62900 -0.18300  24.46700 1.000 26.27605 ? 410 LYS A N   1 
ATOM   3043 C  CA  . LYS A 1 416 ? 42.05500 -0.34000  24.71300 1.000 33.70462 ? 410 LYS A CA  1 
ATOM   3044 C  C   . LYS A 1 416 ? 42.77700 0.74700   23.92200 1.000 36.19676 ? 410 LYS A C   1 
ATOM   3045 O  O   . LYS A 1 416 ? 42.76100 0.73300   22.68700 1.000 37.05697 ? 410 LYS A O   1 
ATOM   3046 C  CB  . LYS A 1 416 ? 42.51500 -1.73900  24.30600 1.000 30.71486 ? 410 LYS A CB  1 
ATOM   3047 C  CG  . LYS A 1 416 ? 44.03000 -1.96600  24.39500 1.000 32.36716 ? 410 LYS A CG  1 
ATOM   3048 C  CD  . LYS A 1 416 ? 44.44400 -3.25700  23.66700 1.000 41.25925 ? 410 LYS A CD  1 
ATOM   3049 C  CE  . LYS A 1 416 ? 45.71900 -3.86200  24.26500 1.000 53.48800 ? 410 LYS A CE  1 
ATOM   3050 N  NZ  . LYS A 1 416 ? 45.69900 -3.95700  25.76900 1.000 49.74770 ? 410 LYS A NZ  1 
ATOM   3051 N  N   . ILE A 1 417 ? 43.38800 1.69400   24.63200 1.000 34.32334 ? 411 ILE A N   1 
ATOM   3052 C  CA  . ILE A 1 417 ? 44.03200 2.86500   24.03800 1.000 38.38223 ? 411 ILE A CA  1 
ATOM   3053 C  C   . ILE A 1 417 ? 45.53000 2.76900   24.30900 1.000 45.75970 ? 411 ILE A C   1 
ATOM   3054 O  O   . ILE A 1 417 ? 45.95000 2.74700   25.47300 1.000 45.84966 ? 411 ILE A O   1 
ATOM   3055 C  CB  . ILE A 1 417 ? 43.45800 4.17200   24.61300 1.000 40.14503 ? 411 ILE A CB  1 
ATOM   3056 C  CG1 . ILE A 1 417 ? 42.01000 4.37800   24.16000 1.000 39.75411 ? 411 ILE A CG1 1 
ATOM   3057 C  CG2 . ILE A 1 417 ? 44.31000 5.36100   24.21300 1.000 40.97991 ? 411 ILE A CG2 1 
ATOM   3058 C  CD1 . ILE A 1 417 ? 41.83700 4.35000   22.65500 1.000 42.87483 ? 411 ILE A CD1 1 
ATOM   3059 N  N   . THR A 1 418 ? 46.33900 2.72100   23.24200 1.000 41.72818 ? 412 THR A N   1 
ATOM   3060 C  CA  . THR A 1 418 ? 47.78800 2.64900   23.43500 1.000 46.32304 ? 412 THR A CA  1 
ATOM   3061 C  C   . THR A 1 418 ? 48.41200 4.01900   23.67200 1.000 51.17870 ? 412 THR A C   1 
ATOM   3062 O  O   . THR A 1 418 ? 49.46000 4.11100   24.31800 1.000 47.54906 ? 412 THR A O   1 
ATOM   3063 C  CB  . THR A 1 418 ? 48.47200 2.01800   22.22600 1.000 47.55501 ? 412 THR A CB  1 
ATOM   3064 O  OG1 . THR A 1 418 ? 48.24000 2.83900   21.07800 1.000 48.32164 ? 412 THR A OG1 1 
ATOM   3065 C  CG2 . THR A 1 418 ? 47.92400 0.61800   21.96700 1.000 43.86857 ? 412 THR A CG2 1 
ATOM   3066 N  N   . GLY A 1 419 ? 47.78200 5.08300   23.17700 1.000 50.96989 ? 413 GLY A N   1 
ATOM   3067 C  CA  . GLY A 1 419 ? 48.39700 6.39100   23.12300 1.000 58.15427 ? 413 GLY A CA  1 
ATOM   3068 C  C   . GLY A 1 419 ? 48.99200 6.73800   21.77700 1.000 55.66777 ? 413 GLY A C   1 
ATOM   3069 O  O   . GLY A 1 419 ? 49.53200 7.83800   21.61700 1.000 64.22678 ? 413 GLY A O   1 
ATOM   3070 N  N   . LYS A 1 420 ? 48.90900 5.83200   20.80700 1.000 54.85665 ? 414 LYS A N   1 
ATOM   3071 C  CA  . LYS A 1 420 ? 49.46800 6.04800   19.48100 1.000 59.91888 ? 414 LYS A CA  1 
ATOM   3072 C  C   . LYS A 1 420 ? 48.43700 6.51600   18.46900 1.000 53.93672 ? 414 LYS A C   1 
ATOM   3073 O  O   . LYS A 1 420 ? 48.81900 7.03000   17.41300 1.000 56.71426 ? 414 LYS A O   1 
ATOM   3074 C  CB  . LYS A 1 420 ? 50.11500 4.75500   18.95900 1.000 56.03252 ? 414 LYS A CB  1 
ATOM   3075 C  CG  . LYS A 1 420 ? 51.20100 4.17300   19.86200 1.000 58.78893 ? 414 LYS A CG  1 
ATOM   3076 C  CD  . LYS A 1 420 ? 52.40300 5.10000   19.95600 1.000 70.44128 ? 414 LYS A CD  1 
ATOM   3077 C  CE  . LYS A 1 420 ? 53.65200 4.47000   19.33900 1.000 72.33255 ? 414 LYS A CE  1 
ATOM   3078 N  NZ  . LYS A 1 420 ? 54.90300 5.21700   19.66200 1.000 67.94572 ? 414 LYS A NZ  1 
ATOM   3079 N  N   . GLU A 1 421 ? 47.14900 6.34200   18.75600 1.000 50.03633 ? 415 GLU A N   1 
ATOM   3080 C  CA  . GLU A 1 421 ? 46.11400 6.64700   17.78000 1.000 49.02726 ? 415 GLU A CA  1 
ATOM   3081 C  C   . GLU A 1 421 ? 45.75500 8.12800   17.74100 1.000 49.74025 ? 415 GLU A C   1 
ATOM   3082 O  O   . GLU A 1 421 ? 44.98800 8.53700   16.86000 1.000 50.09715 ? 415 GLU A O   1 
ATOM   3083 C  CB  . GLU A 1 421 ? 44.85800 5.80600   18.05400 1.000 46.69352 ? 415 GLU A CB  1 
ATOM   3084 C  CG  . GLU A 1 421 ? 44.39800 5.75400   19.51000 1.000 54.12603 ? 415 GLU A CG  1 
ATOM   3085 C  CD  . GLU A 1 421 ? 45.19100 4.77600   20.39200 1.000 49.22885 ? 415 GLU A CD  1 
ATOM   3086 O  OE1 . GLU A 1 421 ? 45.23900 3.56200   20.08800 1.000 50.10381 ? 415 GLU A OE1 1 
ATOM   3087 O  OE2 . GLU A 1 421 ? 45.77800 5.24300   21.38700 1.000 50.24859 ? 415 GLU A OE2 1 
ATOM   3088 N  N   . GLY A 1 422 ? 46.30400 8.93500   18.64400 1.000 43.91676 ? 416 GLY A N   1 
ATOM   3089 C  CA  . GLY A 1 422 ? 45.91600 10.32300  18.75700 1.000 41.35733 ? 416 GLY A CA  1 
ATOM   3090 C  C   . GLY A 1 422 ? 44.86300 10.51300  19.82500 1.000 41.34554 ? 416 GLY A C   1 
ATOM   3091 O  O   . GLY A 1 422 ? 44.48300 9.58300   20.53600 1.000 39.98044 ? 416 GLY A O   1 
ATOM   3092 N  N   . LEU A 1 423 ? 44.36800 11.74800  19.93100 1.000 36.45595 ? 417 LEU A N   1 
ATOM   3093 C  CA  . LEU A 1 423 ? 43.35000 12.05100  20.92800 1.000 31.53363 ? 417 LEU A CA  1 
ATOM   3094 C  C   . LEU A 1 423 ? 41.94000 12.12200  20.36200 1.000 31.43712 ? 417 LEU A C   1 
ATOM   3095 O  O   . LEU A 1 423 ? 40.97900 12.05500  21.14500 1.000 29.82264 ? 417 LEU A O   1 
ATOM   3096 C  CB  . LEU A 1 423 ? 43.64600 13.38200  21.63300 1.000 41.55342 ? 417 LEU A CB  1 
ATOM   3097 C  CG  . LEU A 1 423 ? 44.64600 13.35000  22.78700 1.000 42.69996 ? 417 LEU A CG  1 
ATOM   3098 C  CD1 . LEU A 1 423 ? 44.22000 12.26600  23.81900 1.000 36.64815 ? 417 LEU A CD1 1 
ATOM   3099 C  CD2 . LEU A 1 423 ? 46.08000 13.14900  22.26800 1.000 34.54514 ? 417 LEU A CD2 1 
ATOM   3100 N  N   . TYR A 1 424 ? 41.79300 12.24000  19.03800 1.000 28.20123 ? 418 TYR A N   1 
ATOM   3101 C  CA  . TYR A 1 424 ? 40.49700 12.49100  18.41600 1.000 31.36549 ? 418 TYR A CA  1 
ATOM   3102 C  C   . TYR A 1 424 ? 40.33500 11.69600  17.13000 1.000 27.94257 ? 418 TYR A C   1 
ATOM   3103 O  O   . TYR A 1 424 ? 41.30100 11.43100  16.40900 1.000 31.49496 ? 418 TYR A O   1 
ATOM   3104 C  CB  . TYR A 1 424 ? 40.28400 13.97900  18.05900 1.000 28.07645 ? 418 TYR A CB  1 
ATOM   3105 C  CG  . TYR A 1 424 ? 40.76200 14.95800  19.10800 1.000 31.05686 ? 418 TYR A CG  1 
ATOM   3106 C  CD1 . TYR A 1 424 ? 40.03400 15.16500  20.26500 1.000 28.67620 ? 418 TYR A CD1 1 
ATOM   3107 C  CD2 . TYR A 1 424 ? 41.92700 15.68800  18.92600 1.000 33.52933 ? 418 TYR A CD2 1 
ATOM   3108 C  CE1 . TYR A 1 424 ? 40.45100 16.06200  21.21800 1.000 32.64539 ? 418 TYR A CE1 1 
ATOM   3109 C  CE2 . TYR A 1 424 ? 42.36600 16.58800  19.89200 1.000 31.62576 ? 418 TYR A CE2 1 
ATOM   3110 C  CZ  . TYR A 1 424 ? 41.62400 16.76500  21.03100 1.000 33.07088 ? 418 TYR A CZ  1 
ATOM   3111 O  OH  . TYR A 1 424 ? 42.03000 17.66000  21.98400 1.000 37.66768 ? 418 TYR A OH  1 
ATOM   3112 N  N   . PHE A 1 425 ? 39.08800 11.35000  16.83800 1.000 24.93645 ? 419 PHE A N   1 
ATOM   3113 C  CA  . PHE A 1 425 ? 38.68200 10.88300  15.51800 1.000 30.12668 ? 419 PHE A CA  1 
ATOM   3114 C  C   . PHE A 1 425 ? 37.29100 11.42900  15.24200 1.000 30.69479 ? 419 PHE A C   1 
ATOM   3115 O  O   . PHE A 1 425 ? 36.41800 11.38200  16.11400 1.000 29.66712 ? 419 PHE A O   1 
ATOM   3116 C  CB  . PHE A 1 425 ? 38.67500 9.34500   15.40200 1.000 29.72667 ? 419 PHE A CB  1 
ATOM   3117 C  CG  . PHE A 1 425 ? 38.57900 8.85800   13.97300 1.000 30.77103 ? 419 PHE A CG  1 
ATOM   3118 C  CD1 . PHE A 1 425 ? 37.35100 8.78800   13.32700 1.000 26.90200 ? 419 PHE A CD1 1 
ATOM   3119 C  CD2 . PHE A 1 425 ? 39.72000 8.53000   13.26400 1.000 32.35192 ? 419 PHE A CD2 1 
ATOM   3120 C  CE1 . PHE A 1 425 ? 37.26300 8.37500   11.99900 1.000 31.64886 ? 419 PHE A CE1 1 
ATOM   3121 C  CE2 . PHE A 1 425 ? 39.64400 8.12100   11.94000 1.000 38.22474 ? 419 PHE A CE2 1 
ATOM   3122 C  CZ  . PHE A 1 425 ? 38.41000 8.04300   11.30300 1.000 33.49988 ? 419 PHE A CZ  1 
ATOM   3123 N  N   . SER A 1 426 ? 37.08900 11.97600  14.04800 1.000 30.62372 ? 420 SER A N   1 
ATOM   3124 C  CA  . SER A 1 426 ? 35.76800 12.42200  13.63400 1.000 27.57747 ? 420 SER A CA  1 
ATOM   3125 C  C   . SER A 1 426 ? 35.52000 11.88600  12.23400 1.000 35.49685 ? 420 SER A C   1 
ATOM   3126 O  O   . SER A 1 426 ? 36.41100 11.94600  11.38100 1.000 36.88695 ? 420 SER A O   1 
ATOM   3127 C  CB  . SER A 1 426 ? 35.64100 13.94700  13.67200 1.000 33.36224 ? 420 SER A CB  1 
ATOM   3128 O  OG  . SER A 1 426 ? 34.34100 14.35200  13.29000 1.000 37.93125 ? 420 SER A OG  1 
ATOM   3129 N  N   . GLY A 1 427 ? 34.33100 11.32900  12.00400 1.000 30.25874 ? 421 GLY A N   1 
ATOM   3130 C  CA  . GLY A 1 427 ? 34.02200 10.76600  10.71400 1.000 30.56011 ? 421 GLY A CA  1 
ATOM   3131 C  C   . GLY A 1 427 ? 32.55800 10.42600  10.56300 1.000 32.71487 ? 421 GLY A C   1 
ATOM   3132 O  O   . GLY A 1 427 ? 31.82400 10.28800  11.54700 1.000 31.42846 ? 421 GLY A O   1 
ATOM   3133 N  N   . PRO A 1 428 ? 32.09500 10.32100  9.31700  1.000 31.84069 ? 422 PRO A N   1 
ATOM   3134 C  CA  . PRO A 1 428 ? 30.69500 9.95100   9.08700  1.000 32.47315 ? 422 PRO A CA  1 
ATOM   3135 C  C   . PRO A 1 428 ? 30.47900 8.47900   9.42000  1.000 30.07309 ? 422 PRO A C   1 
ATOM   3136 O  O   . PRO A 1 428 ? 31.33300 7.62900   9.15200  1.000 31.61326 ? 422 PRO A O   1 
ATOM   3137 C  CB  . PRO A 1 428 ? 30.49100 10.22400  7.59000  1.000 29.61384 ? 422 PRO A CB  1 
ATOM   3138 C  CG  . PRO A 1 428 ? 31.87100 10.10800  6.99500  1.000 30.70491 ? 422 PRO A CG  1 
ATOM   3139 C  CD  . PRO A 1 428 ? 32.82200 10.59100  8.06300  1.000 28.86765 ? 422 PRO A CD  1 
ATOM   3140 N  N   . ALA A 1 429 ? 29.32800 8.19000   10.01300 1.000 30.37116 ? 423 ALA A N   1 
ATOM   3141 C  CA  . ALA A 1 429 ? 29.03600 6.82900   10.44100 1.000 30.49993 ? 423 ALA A CA  1 
ATOM   3142 C  C   . ALA A 1 429 ? 28.74300 5.93400   9.24800  1.000 29.94657 ? 423 ALA A C   1 
ATOM   3143 O  O   . ALA A 1 429 ? 28.08600 6.34200   8.28400  1.000 31.73916 ? 423 ALA A O   1 
ATOM   3144 C  CB  . ALA A 1 429 ? 27.85100 6.82000   11.40200 1.000 27.62516 ? 423 ALA A CB  1 
ATOM   3145 N  N   . LEU A 1 430 ? 29.25000 4.70700   9.31700  1.000 28.60621 ? 424 LEU A N   1 
ATOM   3146 C  CA  . LEU A 1 430 ? 28.94800 3.63500   8.36900  1.000 28.67796 ? 424 LEU A CA  1 
ATOM   3147 C  C   . LEU A 1 430 ? 28.37800 2.48800   9.20500  1.000 33.29897 ? 424 LEU A C   1 
ATOM   3148 O  O   . LEU A 1 430 ? 29.13500 1.78700   9.88700  1.000 32.43988 ? 424 LEU A O   1 
ATOM   3149 C  CB  . LEU A 1 430 ? 30.20500 3.21700   7.60900  1.000 27.21485 ? 424 LEU A CB  1 
ATOM   3150 C  CG  . LEU A 1 430 ? 30.02400 2.47500   6.28600  1.000 31.16868 ? 424 LEU A CG  1 
ATOM   3151 C  CD1 . LEU A 1 430 ? 29.09800 3.24100   5.32000  1.000 33.72960 ? 424 LEU A CD1 1 
ATOM   3152 C  CD2 . LEU A 1 430 ? 31.36700 2.18900   5.66200  1.000 36.78063 ? 424 LEU A CD2 1 
ATOM   3153 N  N   . VAL A 1 431 ? 27.05200 2.30000   9.17400  1.000 27.93505 ? 425 VAL A N   1 
ATOM   3154 C  CA  . VAL A 1 431 ? 26.34500 1.48400   10.16500 1.000 32.32308 ? 425 VAL A CA  1 
ATOM   3155 C  C   . VAL A 1 431 ? 26.00200 0.11000   9.59500  1.000 39.18078 ? 425 VAL A C   1 
ATOM   3156 O  O   . VAL A 1 431 ? 25.48300 -0.00500  8.47500  1.000 33.17377 ? 425 VAL A O   1 
ATOM   3157 C  CB  . VAL A 1 431 ? 25.07600 2.18900   10.66300 1.000 32.99093 ? 425 VAL A CB  1 
ATOM   3158 C  CG1 . VAL A 1 431 ? 24.46200 1.39600   11.81100 1.000 36.35883 ? 425 VAL A CG1 1 
ATOM   3159 C  CG2 . VAL A 1 431 ? 25.39400 3.61800   11.12000 1.000 30.33450 ? 425 VAL A CG2 1 
ATOM   3160 N  N   . PHE A 1 432 ? 26.25700 -0.93200  10.38800 1.000 32.85196 ? 426 PHE A N   1 
ATOM   3161 C  CA  . PHE A 1 432 ? 25.95600 -2.30200  10.01200 1.000 30.82992 ? 426 PHE A CA  1 
ATOM   3162 C  C   . PHE A 1 432 ? 25.17800 -2.98700  11.12300 1.000 32.99897 ? 426 PHE A C   1 
ATOM   3163 O  O   . PHE A 1 432 ? 25.50600 -2.83700  12.30600 1.000 27.27340 ? 426 PHE A O   1 
ATOM   3164 C  CB  . PHE A 1 432 ? 27.23900 -3.05300  9.70200  1.000 32.19960 ? 426 PHE A CB  1 
ATOM   3165 C  CG  . PHE A 1 432 ? 27.98800 -2.46100  8.54600  1.000 38.06571 ? 426 PHE A CG  1 
ATOM   3166 C  CD1 . PHE A 1 432 ? 27.55200 -2.67000  7.24500  1.000 35.86238 ? 426 PHE A CD1 1 
ATOM   3167 C  CD2 . PHE A 1 432 ? 29.06500 -1.60500  8.76300  1.000 35.99278 ? 426 PHE A CD2 1 
ATOM   3168 C  CE1 . PHE A 1 432 ? 28.21900 -2.08600  6.17400  1.000 38.32141 ? 426 PHE A CE1 1 
ATOM   3169 C  CE2 . PHE A 1 432 ? 29.74300 -1.02600  7.69400  1.000 33.93727 ? 426 PHE A CE2 1 
ATOM   3170 C  CZ  . PHE A 1 432 ? 29.31100 -1.26300  6.39700  1.000 33.86432 ? 426 PHE A CZ  1 
ATOM   3171 N  N   . GLU A 1 433 ? 24.13000 -3.71600  10.73000 1.000 35.53656 ? 427 GLU A N   1 
ATOM   3172 C  CA  . GLU A 1 433 ? 23.32100 -4.51000  11.65800 1.000 38.17424 ? 427 GLU A CA  1 
ATOM   3173 C  C   . GLU A 1 433 ? 23.88300 -5.92700  11.65500 1.000 39.86697 ? 427 GLU A C   1 
ATOM   3174 O  O   . GLU A 1 433 ? 23.35600 -6.83900  11.01200 1.000 50.84071 ? 427 GLU A O   1 
ATOM   3175 C  CB  . GLU A 1 433 ? 21.84600 -4.49700  11.25600 1.000 36.14547 ? 427 GLU A CB  1 
ATOM   3176 C  CG  . GLU A 1 433 ? 21.34400 -3.19700  10.66000 1.000 36.27680 ? 427 GLU A CG  1 
ATOM   3177 C  CD  . GLU A 1 433 ? 21.02700 -2.14900  11.70600 1.000 36.92716 ? 427 GLU A CD  1 
ATOM   3178 O  OE1 . GLU A 1 433 ? 21.20600 -2.42400  12.91100 1.000 35.63032 ? 427 GLU A OE1 1 
ATOM   3179 O  OE2 . GLU A 1 433 ? 20.59800 -1.04100  11.32600 1.000 38.62814 ? 427 GLU A OE2 1 
ATOM   3180 N  N   . GLY A 1 434 ? 24.99200 -6.10400  12.35700 1.000 33.65712 ? 428 GLY A N   1 
ATOM   3181 C  CA  . GLY A 1 434 ? 25.65100 -7.38800  12.43900 1.000 33.07971 ? 428 GLY A CA  1 
ATOM   3182 C  C   . GLY A 1 434 ? 26.99700 -7.38800  11.72800 1.000 38.08067 ? 428 GLY A C   1 
ATOM   3183 O  O   . GLY A 1 434 ? 27.27400 -6.57800  10.84200 1.000 36.45306 ? 428 GLY A O   1 
ATOM   3184 N  N   . GLU A 1 435 ? 27.83400 -8.35000  12.11900 1.000 30.96220 ? 429 GLU A N   1 
ATOM   3185 C  CA  . GLU A 1 435 ? 29.17800 -8.46000  11.56200 1.000 30.95974 ? 429 GLU A CA  1 
ATOM   3186 C  C   . GLU A 1 435 ? 29.17100 -8.88600  10.10200 1.000 44.63979 ? 429 GLU A C   1 
ATOM   3187 O  O   . GLU A 1 435 ? 30.08800 -8.52200  9.34500  1.000 35.95800 ? 429 GLU A O   1 
ATOM   3188 C  CB  . GLU A 1 435 ? 29.98600 -9.46500  12.36500 1.000 33.33825 ? 429 GLU A CB  1 
ATOM   3189 C  CG  . GLU A 1 435 ? 31.47300 -9.43200  12.16100 1.000 33.23076 ? 429 GLU A CG  1 
ATOM   3190 C  CD  . GLU A 1 435 ? 32.09100 -10.71100 12.64800 1.000 38.43108 ? 429 GLU A CD  1 
ATOM   3191 O  OE1 . GLU A 1 435 ? 31.33800 -11.48000 13.26600 1.000 46.49512 ? 429 GLU A OE1 1 
ATOM   3192 O  OE2 . GLU A 1 435 ? 33.31100 -10.93600 12.47900 1.000 41.60203 ? 429 GLU A OE2 1 
ATOM   3193 N  N   . GLU A 1 436 ? 28.18300 -9.69300  9.70400  1.000 39.41990 ? 430 GLU A N   1 
ATOM   3194 C  CA  . GLU A 1 436 ? 28.15800 -10.22000 8.34700  1.000 41.42594 ? 430 GLU A CA  1 
ATOM   3195 C  C   . GLU A 1 436 ? 28.05000 -9.09800  7.32100  1.000 37.33511 ? 430 GLU A C   1 
ATOM   3196 O  O   . GLU A 1 436 ? 28.84000 -9.04600  6.37600  1.000 35.75294 ? 430 GLU A O   1 
ATOM   3197 C  CB  . GLU A 1 436 ? 27.00900 -11.21700 8.18600  1.000 39.25215 ? 430 GLU A CB  1 
ATOM   3198 C  CG  . GLU A 1 436 ? 27.47000 -12.65900 8.09200  1.000 57.06894 ? 430 GLU A CG  1 
ATOM   3199 C  CD  . GLU A 1 436 ? 26.56700 -13.50900 7.20600  1.000 69.07354 ? 430 GLU A CD  1 
ATOM   3200 O  OE1 . GLU A 1 436 ? 25.33000 -13.47600 7.40000  1.000 71.69175 ? 430 GLU A OE1 1 
ATOM   3201 O  OE2 . GLU A 1 436 ? 27.09900 -14.21500 6.31900  1.000 66.83905 ? 430 GLU A OE2 1 
ATOM   3202 N  N   . SER A 1 437 ? 27.07900 -8.18800  7.49100  1.000 36.50814 ? 431 SER A N   1 
ATOM   3203 C  CA  . SER A 1 437 ? 26.92800 -7.11100  6.51200  1.000 37.53376 ? 431 SER A CA  1 
ATOM   3204 C  C   . SER A 1 437 ? 28.14500 -6.18800  6.49100  1.000 43.33635 ? 431 SER A C   1 
ATOM   3205 O  O   . SER A 1 437 ? 28.50100 -5.67200  5.42600  1.000 40.15487 ? 431 SER A O   1 
ATOM   3206 C  CB  . SER A 1 437 ? 25.65400 -6.30400  6.76000  1.000 35.53493 ? 431 SER A CB  1 
ATOM   3207 O  OG  . SER A 1 437 ? 25.55100 -5.85900  8.09000  1.000 45.80312 ? 431 SER A OG  1 
ATOM   3208 N  N   . MET A 1 438 ? 28.81800 -5.99300  7.63400  1.000 39.67416 ? 432 MET A N   1 
ATOM   3209 C  CA  . MET A 1 438 ? 30.02500 -5.16800  7.63900  1.000 38.01612 ? 432 MET A CA  1 
ATOM   3210 C  C   . MET A 1 438 ? 31.11900 -5.79600  6.79000  1.000 39.63893 ? 432 MET A C   1 
ATOM   3211 O  O   . MET A 1 438 ? 31.78300 -5.11000  6.00400  1.000 35.46308 ? 432 MET A O   1 
ATOM   3212 C  CB  . MET A 1 438 ? 30.52800 -4.93700  9.07200  1.000 33.92172 ? 432 MET A CB  1 
ATOM   3213 C  CG  . MET A 1 438 ? 31.82100 -4.11900  9.12000  1.000 27.06885 ? 432 MET A CG  1 
ATOM   3214 S  SD  . MET A 1 438 ? 33.32400 -5.09800  9.02800  1.000 31.62504 ? 432 MET A SD  1 
ATOM   3215 C  CE  . MET A 1 438 ? 34.60300 -3.87800  9.37000  1.000 34.47822 ? 432 MET A CE  1 
ATOM   3216 N  N   . LEU A 1 439 ? 31.33000 -7.10500  6.94300  1.000 35.92330 ? 433 LEU A N   1 
ATOM   3217 C  CA  . LEU A 1 439 ? 32.42500 -7.75800  6.22500  1.000 38.61084 ? 433 LEU A CA  1 
ATOM   3218 C  C   . LEU A 1 439 ? 32.15900 -7.82800  4.72700  1.000 36.61476 ? 433 LEU A C   1 
ATOM   3219 O  O   . LEU A 1 439 ? 33.10300 -7.78800  3.93000  1.000 40.05286 ? 433 LEU A O   1 
ATOM   3220 C  CB  . LEU A 1 439 ? 32.65400 -9.17000  6.75800  1.000 35.24276 ? 433 LEU A CB  1 
ATOM   3221 C  CG  . LEU A 1 439 ? 33.00800 -9.24600  8.23300  1.000 37.00336 ? 433 LEU A CG  1 
ATOM   3222 C  CD1 . LEU A 1 439 ? 32.71500 -10.64100 8.75500  1.000 40.13433 ? 433 LEU A CD1 1 
ATOM   3223 C  CD2 . LEU A 1 439 ? 34.45200 -8.84400  8.42700  1.000 37.55725 ? 433 LEU A CD2 1 
ATOM   3224 N  N   . ALA A 1 440 ? 30.89500 -7.97500  4.33700  1.000 35.29875 ? 434 ALA A N   1 
ATOM   3225 C  CA  . ALA A 1 440 ? 30.55500 -7.98100  2.92000  1.000 41.99203 ? 434 ALA A CA  1 
ATOM   3226 C  C   . ALA A 1 440 ? 30.77900 -6.60800  2.30700  1.000 48.80893 ? 434 ALA A C   1 
ATOM   3227 O  O   . ALA A 1 440 ? 31.27600 -6.50000  1.18000  1.000 46.78970 ? 434 ALA A O   1 
ATOM   3228 C  CB  . ALA A 1 440 ? 29.10100 -8.41300  2.73000  1.000 39.29481 ? 434 ALA A CB  1 
ATOM   3229 N  N   . ALA A 1 441 ? 30.42000 -5.54600  3.03700  1.000 41.74126 ? 435 ALA A N   1 
ATOM   3230 C  CA  . ALA A 1 441 ? 30.56300 -4.20200  2.49100  1.000 42.34512 ? 435 ALA A CA  1 
ATOM   3231 C  C   . ALA A 1 441 ? 32.02900 -3.82700  2.33000  1.000 41.52349 ? 435 ALA A C   1 
ATOM   3232 O  O   . ALA A 1 441 ? 32.40700 -3.20700  1.33100  1.000 47.16610 ? 435 ALA A O   1 
ATOM   3233 C  CB  . ALA A 1 441 ? 29.82700 -3.19800  3.37400  1.000 35.20131 ? 435 ALA A CB  1 
ATOM   3234 N  N   . ILE A 1 442 ? 32.88200 -4.23300  3.27500  1.000 38.27303 ? 436 ILE A N   1 
ATOM   3235 C  CA  . ILE A 1 442 ? 34.29800 -3.91300  3.16200  1.000 38.49692 ? 436 ILE A CA  1 
ATOM   3236 C  C   . ILE A 1 442 ? 34.97600 -4.80000  2.12900  1.000 45.75510 ? 436 ILE A C   1 
ATOM   3237 O  O   . ILE A 1 442 ? 36.05900 -4.45800  1.62500  1.000 44.33110 ? 436 ILE A O   1 
ATOM   3238 C  CB  . ILE A 1 442 ? 34.98100 -3.99900  4.54400  1.000 40.50093 ? 436 ILE A CB  1 
ATOM   3239 C  CG1 . ILE A 1 442 ? 36.32500 -3.26600  4.52800  1.000 42.38371 ? 436 ILE A CG1 1 
ATOM   3240 C  CG2 . ILE A 1 442 ? 35.16200 -5.45200  4.98300  1.000 41.05966 ? 436 ILE A CG2 1 
ATOM   3241 C  CD1 . ILE A 1 442 ? 37.02800 -3.22100  5.87600  1.000 35.59265 ? 436 ILE A CD1 1 
ATOM   3242 N  N   . SER A 1 443 ? 34.36400 -5.93500  1.78800  1.000 45.25011 ? 437 SER A N   1 
ATOM   3243 C  CA  . SER A 1 443 ? 34.89500 -6.75100  0.70000  1.000 51.42149 ? 437 SER A CA  1 
ATOM   3244 C  C   . SER A 1 443 ? 34.60600 -6.10300  -0.64800 1.000 45.30509 ? 437 SER A C   1 
ATOM   3245 O  O   . SER A 1 443 ? 35.51800 -5.87100  -1.45200 1.000 52.24898 ? 437 SER A O   1 
ATOM   3246 C  CB  . SER A 1 443 ? 34.30100 -8.16300  0.76100  1.000 52.41947 ? 437 SER A CB  1 
ATOM   3247 O  OG  . SER A 1 443 ? 35.03000 -9.05500  -0.07300 1.000 60.16220 ? 437 SER A OG  1 
ATOM   3248 N  N   . ALA A 1 444 ? 33.33700 -5.79200  -0.90100 1.000 45.10315 ? 438 ALA A N   1 
ATOM   3249 C  CA  . ALA A 1 444 ? 32.94700 -5.22200  -2.18200 1.000 43.56725 ? 438 ALA A CA  1 
ATOM   3250 C  C   . ALA A 1 444 ? 33.53800 -3.83000  -2.38500 1.000 45.78290 ? 438 ALA A C   1 
ATOM   3251 O  O   . ALA A 1 444 ? 33.99100 -3.50100  -3.48500 1.000 51.38182 ? 438 ALA A O   1 
ATOM   3252 C  CB  . ALA A 1 444 ? 31.42200 -5.18000  -2.28200 1.000 41.82294 ? 438 ALA A CB  1 
ATOM   3253 N  N   . ASP A 1 445 ? 33.56600 -3.00400  -1.33900 1.000 45.33669 ? 439 ASP A N   1 
ATOM   3254 C  CA  . ASP A 1 445 ? 33.86500 -1.57500  -1.47100 1.000 42.42422 ? 439 ASP A CA  1 
ATOM   3255 C  C   . ASP A 1 445 ? 34.72800 -1.08800  -0.31000 1.000 42.65782 ? 439 ASP A C   1 
ATOM   3256 O  O   . ASP A 1 445 ? 34.27700 -0.29700  0.52700  1.000 41.11195 ? 439 ASP A O   1 
ATOM   3257 C  CB  . ASP A 1 445 ? 32.56000 -0.77700  -1.54300 1.000 42.88327 ? 439 ASP A CB  1 
ATOM   3258 C  CG  . ASP A 1 445 ? 32.74200 0.58500   -2.18300 1.000 46.92404 ? 439 ASP A CG  1 
ATOM   3259 O  OD1 . ASP A 1 445 ? 33.89900 0.91900   -2.51100 1.000 41.58935 ? 439 ASP A OD1 1 
ATOM   3260 O  OD2 . ASP A 1 445 ? 31.73500 1.31500   -2.34500 1.000 44.45643 ? 439 ASP A OD2 1 
ATOM   3261 N  N   . PRO A 1 446 ? 35.99400 -1.52100  -0.24500 1.000 38.68648 ? 440 PRO A N   1 
ATOM   3262 C  CA  . PRO A 1 446 ? 36.83400 -1.11200  0.89700  1.000 40.65614 ? 440 PRO A CA  1 
ATOM   3263 C  C   . PRO A 1 446 ? 37.01500 0.39100   1.01600  1.000 44.72478 ? 440 PRO A C   1 
ATOM   3264 O  O   . PRO A 1 446 ? 37.02800 0.92100   2.13300  1.000 42.06412 ? 440 PRO A O   1 
ATOM   3265 C  CB  . PRO A 1 446 ? 38.16900 -1.82800  0.63800  1.000 39.96946 ? 440 PRO A CB  1 
ATOM   3266 C  CG  . PRO A 1 446 ? 38.12300 -2.26000  -0.78500 1.000 41.73737 ? 440 PRO A CG  1 
ATOM   3267 C  CD  . PRO A 1 446 ? 36.68700 -2.46900  -1.13100 1.000 40.30726 ? 440 PRO A CD  1 
ATOM   3268 N  N   . MET A 1 447 ? 37.12600 1.10400   -0.10400 1.000 44.10583 ? 441 MET A N   1 
ATOM   3269 C  CA  . MET A 1 447 ? 37.40800 2.52900   -0.01300 1.000 43.29947 ? 441 MET A CA  1 
ATOM   3270 C  C   . MET A 1 447 ? 36.23600 3.32100   0.54100  1.000 40.32994 ? 441 MET A C   1 
ATOM   3271 O  O   . MET A 1 447 ? 36.45200 4.41100   1.08500  1.000 38.94082 ? 441 MET A O   1 
ATOM   3272 C  CB  . MET A 1 447 ? 37.83200 3.07500   -1.38000 1.000 47.86091 ? 441 MET A CB  1 
ATOM   3273 C  CG  . MET A 1 447 ? 39.05600 2.37300   -1.93600 1.000 46.92550 ? 441 MET A CG  1 
ATOM   3274 S  SD  . MET A 1 447 ? 40.49800 2.68600   -0.89300 1.000 65.52613 ? 441 MET A SD  1 
ATOM   3275 C  CE  . MET A 1 447 ? 40.92600 1.01700   -0.39300 1.000 50.60176 ? 441 MET A CE  1 
ATOM   3276 N  N   . SER A 1 448 ? 35.01100 2.80000   0.44100  1.000 35.73886 ? 442 SER A N   1 
ATOM   3277 C  CA  . SER A 1 448 ? 33.87900 3.45000   1.09600  1.000 39.57515 ? 442 SER A CA  1 
ATOM   3278 C  C   . SER A 1 448 ? 34.05100 3.55500   2.61500  1.000 36.80180 ? 442 SER A C   1 
ATOM   3279 O  O   . SER A 1 448 ? 33.30200 4.29900   3.25800  1.000 33.70656 ? 442 SER A O   1 
ATOM   3280 C  CB  . SER A 1 448 ? 32.58400 2.70100   0.74400  1.000 44.06604 ? 442 SER A CB  1 
ATOM   3281 O  OG  . SER A 1 448 ? 32.51600 1.42200   1.37500  1.000 42.28915 ? 442 SER A OG  1 
ATOM   3282 N  N   . PHE A 1 449 ? 35.02000 2.84300   3.19500  1.000 34.70765 ? 443 PHE A N   1 
ATOM   3283 C  CA  . PHE A 1 449 ? 35.24900 2.85100   4.63900  1.000 33.56232 ? 443 PHE A CA  1 
ATOM   3284 C  C   . PHE A 1 449 ? 36.22900 3.92800   5.07100  1.000 36.73337 ? 443 PHE A C   1 
ATOM   3285 O  O   . PHE A 1 449 ? 36.24700 4.30700   6.25400  1.000 34.32671 ? 443 PHE A O   1 
ATOM   3286 C  CB  . PHE A 1 449 ? 35.77900 1.48000   5.09100  1.000 36.10430 ? 443 PHE A CB  1 
ATOM   3287 C  CG  . PHE A 1 449 ? 34.70000 0.45300   5.27500  1.000 36.81145 ? 443 PHE A CG  1 
ATOM   3288 C  CD1 . PHE A 1 449 ? 33.93500 0.03000   4.19600  1.000 37.05284 ? 443 PHE A CD1 1 
ATOM   3289 C  CD2 . PHE A 1 449 ? 34.44200 -0.08400  6.52600  1.000 35.16044 ? 443 PHE A CD2 1 
ATOM   3290 C  CE1 . PHE A 1 449 ? 32.92800 -0.90900  4.36100  1.000 37.37272 ? 443 PHE A CE1 1 
ATOM   3291 C  CE2 . PHE A 1 449 ? 33.43300 -1.02300  6.70100  1.000 34.36200 ? 443 PHE A CE2 1 
ATOM   3292 C  CZ  . PHE A 1 449 ? 32.67700 -1.43400  5.62100  1.000 36.19217 ? 443 PHE A CZ  1 
ATOM   3293 N  N   . LYS A 1 450 ? 37.02800 4.42800   4.13400  1.000 36.32430 ? 444 LYS A N   1 
ATOM   3294 C  CA  . LYS A 1 450 ? 38.09300 5.37200   4.43800  1.000 38.32877 ? 444 LYS A CA  1 
ATOM   3295 C  C   . LYS A 1 450 ? 37.51400 6.62900   5.08800  1.000 33.40425 ? 444 LYS A C   1 
ATOM   3296 O  O   . LYS A 1 450 ? 36.62200 7.27800   4.52900  1.000 31.14309 ? 444 LYS A O   1 
ATOM   3297 C  CB  . LYS A 1 450 ? 38.84100 5.70100   3.14500  1.000 32.74527 ? 444 LYS A CB  1 
ATOM   3298 C  CG  . LYS A 1 450 ? 40.14100 6.44500   3.32500  1.000 42.93697 ? 444 LYS A CG  1 
ATOM   3299 C  CD  . LYS A 1 450 ? 40.84900 6.70200   1.98800  1.000 39.89216 ? 444 LYS A CD  1 
ATOM   3300 C  CE  . LYS A 1 450 ? 42.30200 7.08800   2.22600  1.000 47.16560 ? 444 LYS A CE  1 
ATOM   3301 N  NZ  . LYS A 1 450 ? 42.90100 7.84800   1.08400  1.000 52.05968 ? 444 LYS A NZ  1 
ATOM   3302 N  N   . GLY A 1 451 ? 38.00400 6.95300   6.28600  1.000 33.02879 ? 445 GLY A N   1 
ATOM   3303 C  CA  . GLY A 1 451 ? 37.53900 8.10700   7.03000  1.000 32.48681 ? 445 GLY A CA  1 
ATOM   3304 C  C   . GLY A 1 451 ? 36.27600 7.91800   7.85100  1.000 33.81376 ? 445 GLY A C   1 
ATOM   3305 O  O   . GLY A 1 451 ? 35.86700 8.86000   8.54300  1.000 30.41375 ? 445 GLY A O   1 
ATOM   3306 N  N   . THR A 1 452 ? 35.63300 6.75300   7.79900  1.000 27.93129 ? 446 THR A N   1 
ATOM   3307 C  CA  . THR A 1 452 ? 34.34600 6.61700   8.46600  1.000 28.28239 ? 446 THR A CA  1 
ATOM   3308 C  C   . THR A 1 452 ? 34.52700 6.15800   9.91400  1.000 25.11599 ? 446 THR A C   1 
ATOM   3309 O  O   . THR A 1 452 ? 35.60600 5.73900   10.33900 1.000 27.27038 ? 446 THR A O   1 
ATOM   3310 C  CB  . THR A 1 452 ? 33.43700 5.64100   7.71400  1.000 29.50488 ? 446 THR A CB  1 
ATOM   3311 O  OG1 . THR A 1 452 ? 34.00400 4.32400   7.76100  1.000 29.41862 ? 446 THR A OG1 1 
ATOM   3312 C  CG2 . THR A 1 452 ? 33.26700 6.08000   6.26100  1.000 26.30491 ? 446 THR A CG2 1 
ATOM   3313 N  N   . VAL A 1 453 ? 33.44900 6.27200   10.67800 1.000 28.51416 ? 447 VAL A N   1 
ATOM   3314 C  CA  . VAL A 1 453 ? 33.32100 5.61500   11.97600 1.000 32.39250 ? 447 VAL A CA  1 
ATOM   3315 C  C   . VAL A 1 453 ? 32.41600 4.41700   11.72800 1.000 24.00717 ? 447 VAL A C   1 
ATOM   3316 O  O   . VAL A 1 453 ? 31.20400 4.56400   11.52700 1.000 28.78906 ? 447 VAL A O   1 
ATOM   3317 C  CB  . VAL A 1 453 ? 32.76400 6.55200   13.05200 1.000 31.27371 ? 447 VAL A CB  1 
ATOM   3318 C  CG1 . VAL A 1 453 ? 32.58600 5.80800   14.38900 1.000 25.62525 ? 447 VAL A CG1 1 
ATOM   3319 C  CG2 . VAL A 1 453 ? 33.69100 7.74900   13.24200 1.000 27.06353 ? 447 VAL A CG2 1 
ATOM   3320 N  N   . VAL A 1 454 ? 33.02100 3.24100   11.65700 1.000 29.31840 ? 448 VAL A N   1 
ATOM   3321 C  CA  . VAL A 1 454 ? 32.28800 1.99900   11.41000 1.000 25.01064 ? 448 VAL A CA  1 
ATOM   3322 C  C   . VAL A 1 454 ? 31.56700 1.56800   12.67700 1.000 30.46904 ? 448 VAL A C   1 
ATOM   3323 O  O   . VAL A 1 454 ? 32.18400 1.42700   13.74100 1.000 30.00927 ? 448 VAL A O   1 
ATOM   3324 C  CB  . VAL A 1 454 ? 33.23700 0.89400   10.92200 1.000 25.17663 ? 448 VAL A CB  1 
ATOM   3325 C  CG1 . VAL A 1 454 ? 32.45900 -0.40900  10.68700 1.000 27.53413 ? 448 VAL A CG1 1 
ATOM   3326 C  CG2 . VAL A 1 454 ? 33.94300 1.33600   9.64900  1.000 28.11171 ? 448 VAL A CG2 1 
ATOM   3327 N  N   . VAL A 1 455 ? 30.26300 1.33200   12.55800 1.000 29.88386 ? 449 VAL A N   1 
ATOM   3328 C  CA  . VAL A 1 455 ? 29.42200 0.90800   13.67000 1.000 30.50779 ? 449 VAL A CA  1 
ATOM   3329 C  C   . VAL A 1 455 ? 28.88600 -0.48300  13.35900 1.000 30.60253 ? 449 VAL A C   1 
ATOM   3330 O  O   . VAL A 1 455 ? 28.14800 -0.66600  12.38200 1.000 29.31974 ? 449 VAL A O   1 
ATOM   3331 C  CB  . VAL A 1 455 ? 28.26100 1.87600   13.91300 1.000 31.27701 ? 449 VAL A CB  1 
ATOM   3332 C  CG1 . VAL A 1 455 ? 27.38500 1.33500   15.03800 1.000 32.16603 ? 449 VAL A CG1 1 
ATOM   3333 C  CG2 . VAL A 1 455 ? 28.77000 3.26300   14.24700 1.000 26.79987 ? 449 VAL A CG2 1 
ATOM   3334 N  N   . ILE A 1 456 ? 29.24900 -1.46100  14.18500 1.000 23.61865 ? 450 ILE A N   1 
ATOM   3335 C  CA  . ILE A 1 456 ? 28.66600 -2.79600  14.10100 1.000 25.35205 ? 450 ILE A CA  1 
ATOM   3336 C  C   . ILE A 1 456 ? 27.78800 -2.95800  15.33200 1.000 27.30796 ? 450 ILE A C   1 
ATOM   3337 O  O   . ILE A 1 456 ? 28.29800 -3.10400  16.45100 1.000 26.07917 ? 450 ILE A O   1 
ATOM   3338 C  CB  . ILE A 1 456 ? 29.73900 -3.89000  14.01300 1.000 28.04187 ? 450 ILE A CB  1 
ATOM   3339 C  CG1 . ILE A 1 456 ? 30.62300 -3.67200  12.78100 1.000 25.87262 ? 450 ILE A CG1 1 
ATOM   3340 C  CG2 . ILE A 1 456 ? 29.10600 -5.30200  14.01000 1.000 28.42370 ? 450 ILE A CG2 1 
ATOM   3341 C  CD1 . ILE A 1 456 ? 31.82100 -4.61400  12.72300 1.000 26.12398 ? 450 ILE A CD1 1 
ATOM   3342 N  N   . ARG A 1 457 ? 26.47300 -2.88100  15.14700 1.000 24.01791 ? 451 ARG A N   1 
ATOM   3343 C  CA  . ARG A 1 457 ? 25.54000 -2.93700  16.25800 1.000 23.73961 ? 451 ARG A CA  1 
ATOM   3344 C  C   . ARG A 1 457 ? 24.73100 -4.22800  16.19800 1.000 25.43667 ? 451 ARG A C   1 
ATOM   3345 O  O   . ARG A 1 457 ? 24.85100 -5.03300  15.26700 1.000 27.86198 ? 451 ARG A O   1 
ATOM   3346 C  CB  . ARG A 1 457 ? 24.61200 -1.72200  16.27200 1.000 23.06181 ? 451 ARG A CB  1 
ATOM   3347 C  CG  . ARG A 1 457 ? 23.82800 -1.50200  15.00600 1.000 28.05565 ? 451 ARG A CG  1 
ATOM   3348 C  CD  . ARG A 1 457 ? 22.97600 -0.25700  15.17400 1.000 30.45521 ? 451 ARG A CD  1 
ATOM   3349 N  NE  . ARG A 1 457 ? 22.12600 -0.05300  14.01400 1.000 32.22275 ? 451 ARG A NE  1 
ATOM   3350 C  CZ  . ARG A 1 457 ? 21.67000 1.12400   13.61700 1.000 34.15884 ? 451 ARG A CZ  1 
ATOM   3351 N  NH1 . ARG A 1 457 ? 21.95500 2.23700   14.28200 1.000 25.68944 ? 451 ARG A NH1 1 
ATOM   3352 N  NH2 . ARG A 1 457 ? 20.92800 1.18700   12.51600 1.000 30.12360 ? 451 ARG A NH2 1 
ATOM   3353 N  N   . GLY A 1 458 ? 23.89700 -4.41500  17.21300 1.000 25.54679 ? 452 GLY A N   1 
ATOM   3354 C  CA  . GLY A 1 458 ? 23.19400 -5.67300  17.36000 1.000 26.28568 ? 452 GLY A CA  1 
ATOM   3355 C  C   . GLY A 1 458 ? 24.06500 -6.82600  17.77800 1.000 22.95710 ? 452 GLY A C   1 
ATOM   3356 O  O   . GLY A 1 458 ? 23.68600 -7.97900  17.56400 1.000 26.78466 ? 452 GLY A O   1 
ATOM   3357 N  N   . GLU A 1 459 ? 25.22500 -6.56400  18.38200 1.000 24.16241 ? 453 GLU A N   1 
ATOM   3358 C  CA  . GLU A 1 459 ? 26.09800 -7.63900  18.84200 1.000 21.63677 ? 453 GLU A CA  1 
ATOM   3359 C  C   . GLU A 1 459 ? 26.22600 -7.67200  20.36200 1.000 22.90246 ? 453 GLU A C   1 
ATOM   3360 O  O   . GLU A 1 459 ? 27.16200 -8.27700  20.89000 1.000 23.44399 ? 453 GLU A O   1 
ATOM   3361 C  CB  . GLU A 1 459 ? 27.47500 -7.52200  18.18700 1.000 24.04571 ? 453 GLU A CB  1 
ATOM   3362 C  CG  . GLU A 1 459 ? 27.43900 -7.62100  16.65800 1.000 27.15384 ? 453 GLU A CG  1 
ATOM   3363 C  CD  . GLU A 1 459 ? 27.06500 -9.00600  16.12200 1.000 32.11637 ? 453 GLU A CD  1 
ATOM   3364 O  OE1 . GLU A 1 459 ? 26.82000 -9.95800  16.90800 1.000 26.20674 ? 453 GLU A OE1 1 
ATOM   3365 O  OE2 . GLU A 1 459 ? 26.99600 -9.13800  14.88500 1.000 28.70693 ? 453 GLU A OE2 1 
ATOM   3366 N  N   . GLY A 1 460 ? 25.31900 -7.02400  21.08100 1.000 21.50100 ? 454 GLY A N   1 
ATOM   3367 C  CA  . GLY A 1 460 ? 25.42300 -6.96300  22.52300 1.000 23.82960 ? 454 GLY A CA  1 
ATOM   3368 C  C   . GLY A 1 460 ? 24.99700 -8.26400  23.19000 1.000 21.23264 ? 454 GLY A C   1 
ATOM   3369 O  O   . GLY A 1 460 ? 24.73500 -9.27800  22.52600 1.000 19.95032 ? 454 GLY A O   1 
ATOM   3370 N  N   . PRO A 1 461 ? 24.90500 -8.24200  24.52500 1.000 22.17246 ? 455 PRO A N   1 
ATOM   3371 C  CA  . PRO A 1 461 ? 24.46800 -9.44600  25.25800 1.000 22.01695 ? 455 PRO A CA  1 
ATOM   3372 C  C   . PRO A 1 461 ? 23.13400 -9.98700  24.78900 1.000 22.54576 ? 455 PRO A C   1 
ATOM   3373 O  O   . PRO A 1 461 ? 22.98400 -11.20300 24.63400 1.000 21.81594 ? 455 PRO A O   1 
ATOM   3374 C  CB  . PRO A 1 461 ? 24.39800 -8.95500  26.70800 1.000 21.47573 ? 455 PRO A CB  1 
ATOM   3375 C  CG  . PRO A 1 461 ? 25.35600 -7.80600  26.75300 1.000 22.36702 ? 455 PRO A CG  1 
ATOM   3376 C  CD  . PRO A 1 461 ? 25.19300 -7.12100  25.43200 1.000 20.69500 ? 455 PRO A CD  1 
ATOM   3377 N  N   . LYS A 1 462 ? 22.15200 -9.12100  24.54600 1.000 25.08701 ? 456 LYS A N   1 
ATOM   3378 C  CA  . LYS A 1 462 ? 20.86200 -9.60800  24.06700 1.000 21.52659 ? 456 LYS A CA  1 
ATOM   3379 C  C   . LYS A 1 462 ? 20.72400 -9.57900  22.54800 1.000 25.01229 ? 456 LYS A C   1 
ATOM   3380 O  O   . LYS A 1 462 ? 20.07000 -10.46300 21.97700 1.000 24.85065 ? 456 LYS A O   1 
ATOM   3381 C  CB  . LYS A 1 462 ? 19.73100 -8.79500  24.70000 1.000 20.66212 ? 456 LYS A CB  1 
ATOM   3382 C  CG  . LYS A 1 462 ? 19.68400 -8.93000  26.21500 1.000 24.31137 ? 456 LYS A CG  1 
ATOM   3383 C  CD  . LYS A 1 462 ? 18.75400 -7.92600  26.88200 1.000 27.83184 ? 456 LYS A CD  1 
ATOM   3384 C  CE  . LYS A 1 462 ? 17.31600 -8.37900  26.76400 1.000 34.28607 ? 456 LYS A CE  1 
ATOM   3385 N  NZ  . LYS A 1 462 ? 16.30100 -7.28900  26.86400 1.000 36.39274 ? 456 LYS A NZ  1 
ATOM   3386 N  N   . GLY A 1 463 ? 21.33800 -8.60200  21.87300 1.000 21.16991 ? 457 GLY A N   1 
ATOM   3387 C  CA  . GLY A 1 463 ? 21.17900 -8.50500  20.43200 1.000 23.54568 ? 457 GLY A CA  1 
ATOM   3388 C  C   . GLY A 1 463 ? 21.97000 -9.51600  19.63000 1.000 26.26341 ? 457 GLY A C   1 
ATOM   3389 O  O   . GLY A 1 463 ? 21.52100 -9.93800  18.55900 1.000 24.23335 ? 457 GLY A O   1 
ATOM   3390 N  N   . GLY A 1 464 ? 23.16300 -9.89000  20.09400 1.000 19.37621 ? 458 GLY A N   1 
ATOM   3391 C  CA  . GLY A 1 464 ? 24.00900 -10.80300 19.34900 1.000 21.52247 ? 458 GLY A CA  1 
ATOM   3392 C  C   . GLY A 1 464 ? 23.31800 -12.09900 18.91900 1.000 23.93591 ? 458 GLY A C   1 
ATOM   3393 O  O   . GLY A 1 464 ? 23.37800 -12.48500 17.75100 1.000 26.08608 ? 458 GLY A O   1 
ATOM   3394 N  N   . PRO A 1 465 ? 22.69400 -12.83500 19.86500 1.000 24.73268 ? 459 PRO A N   1 
ATOM   3395 C  CA  . PRO A 1 465 ? 22.80300 -12.65300 21.32100 1.000 21.37173 ? 459 PRO A CA  1 
ATOM   3396 C  C   . PRO A 1 465 ? 24.15900 -13.15300 21.78800 1.000 21.23080 ? 459 PRO A C   1 
ATOM   3397 O  O   . PRO A 1 465 ? 24.90300 -13.68500 20.96800 1.000 21.61859 ? 459 PRO A O   1 
ATOM   3398 C  CB  . PRO A 1 465 ? 21.66500 -13.52100 21.87300 1.000 23.79599 ? 459 PRO A CB  1 
ATOM   3399 C  CG  . PRO A 1 465 ? 21.50300 -14.60000 20.84100 1.000 20.44655 ? 459 PRO A CG  1 
ATOM   3400 C  CD  . PRO A 1 465 ? 21.81200 -13.97400 19.51600 1.000 20.78373 ? 459 PRO A CD  1 
ATOM   3401 N  N   . GLY A 1 466 ? 24.47800 -13.00500 23.07000 1.000 21.97889 ? 460 GLY A N   1 
ATOM   3402 C  CA  . GLY A 1 466 ? 25.68600 -13.60600 23.60100 1.000 23.57046 ? 460 GLY A CA  1 
ATOM   3403 C  C   . GLY A 1 466 ? 26.89600 -12.70200 23.64100 1.000 24.22810 ? 460 GLY A C   1 
ATOM   3404 O  O   . GLY A 1 466 ? 27.96100 -13.13500 24.11100 1.000 21.93516 ? 460 GLY A O   1 
ATOM   3405 N  N   . MET A 1 467 ? 26.76400 -11.46300 23.17300 1.000 22.19155 ? 461 MET A N   1 
ATOM   3406 C  CA  . MET A 1 467 ? 27.86500 -10.50800 23.10300 1.000 23.45803 ? 461 MET A CA  1 
ATOM   3407 C  C   . MET A 1 467 ? 29.11600 -11.16500 22.50500 1.000 25.02139 ? 461 MET A C   1 
ATOM   3408 O  O   . MET A 1 467 ? 30.14800 -11.27200 23.16800 1.000 22.11941 ? 461 MET A O   1 
ATOM   3409 C  CB  . MET A 1 467 ? 28.16700 -9.91700  24.47400 1.000 22.04327 ? 461 MET A CB  1 
ATOM   3410 C  CG  . MET A 1 467 ? 28.90800 -8.56700  24.39200 1.000 21.04361 ? 461 MET A CG  1 
ATOM   3411 S  SD  . MET A 1 467 ? 29.50200 -7.99900  25.98400 1.000 23.41033 ? 461 MET A SD  1 
ATOM   3412 C  CE  . MET A 1 467 ? 30.07600 -6.33100  25.54700 1.000 23.89960 ? 461 MET A CE  1 
ATOM   3413 N  N   . PRO A 1 468 ? 29.04600 -11.63000 21.25900 1.000 22.07503 ? 462 PRO A N   1 
ATOM   3414 C  CA  . PRO A 1 468 ? 30.18600 -12.33900 20.68300 1.000 23.53458 ? 462 PRO A CA  1 
ATOM   3415 C  C   . PRO A 1 468 ? 31.39100 -11.42200 20.51600 1.000 28.02683 ? 462 PRO A C   1 
ATOM   3416 O  O   . PRO A 1 468 ? 31.25800 -10.20300 20.34400 1.000 24.94336 ? 462 PRO A O   1 
ATOM   3417 C  CB  . PRO A 1 468 ? 29.65100 -12.81500 19.32700 1.000 24.65552 ? 462 PRO A CB  1 
ATOM   3418 C  CG  . PRO A 1 468 ? 28.56900 -11.83900 18.99200 1.000 24.91895 ? 462 PRO A CG  1 
ATOM   3419 C  CD  . PRO A 1 468 ? 27.93800 -11.49200 20.30200 1.000 25.36725 ? 462 PRO A CD  1 
ATOM   3420 N  N   . GLU A 1 469 ? 32.57900 -12.02300 20.63300 1.000 21.80498 ? 463 GLU A N   1 
ATOM   3421 C  CA  . GLU A 1 469 ? 33.82500 -11.36500 20.24100 1.000 28.46217 ? 463 GLU A CA  1 
ATOM   3422 C  C   . GLU A 1 469 ? 34.03100 -11.46800 18.73600 1.000 26.65699 ? 463 GLU A C   1 
ATOM   3423 O  O   . GLU A 1 469 ? 33.85600 -12.53600 18.14500 1.000 29.12056 ? 463 GLU A O   1 
ATOM   3424 C  CB  . GLU A 1 469 ? 35.02200 -12.02300 20.90500 1.000 28.90438 ? 463 GLU A CB  1 
ATOM   3425 C  CG  . GLU A 1 469 ? 35.48100 -11.43100 22.17300 1.000 37.20534 ? 463 GLU A CG  1 
ATOM   3426 C  CD  . GLU A 1 469 ? 36.79400 -12.04500 22.58800 1.000 43.44987 ? 463 GLU A CD  1 
ATOM   3427 O  OE1 . GLU A 1 469 ? 36.78500 -13.22700 22.97700 1.000 43.54644 ? 463 GLU A OE1 1 
ATOM   3428 O  OE2 . GLU A 1 469 ? 37.82700 -11.35900 22.48800 1.000 48.58778 ? 463 GLU A OE2 1 
ATOM   3429 N  N   . MET A 1 470 ? 34.44500 -10.36800 18.11900 1.000 31.60308 ? 464 MET A N   1 
ATOM   3430 C  CA  . MET A 1 470 ? 34.61200 -10.30500 16.67100 1.000 28.84411 ? 464 MET A CA  1 
ATOM   3431 C  C   . MET A 1 470 ? 36.03900 -9.88800  16.34700 1.000 36.12827 ? 464 MET A C   1 
ATOM   3432 O  O   . MET A 1 470 ? 36.48600 -8.80500  16.75700 1.000 31.80206 ? 464 MET A O   1 
ATOM   3433 C  CB  . MET A 1 470 ? 33.61900 -9.31600  16.06400 1.000 31.70857 ? 464 MET A CB  1 
ATOM   3434 C  CG  . MET A 1 470 ? 32.18200 -9.67500  16.29500 1.000 27.43521 ? 464 MET A CG  1 
ATOM   3435 S  SD  . MET A 1 470 ? 31.15200 -8.26400  15.87600 1.000 29.67247 ? 464 MET A SD  1 
ATOM   3436 C  CE  . MET A 1 470 ? 31.60200 -7.15100  17.20800 1.000 32.39586 ? 464 MET A CE  1 
ATOM   3437 N  N   . LEU A 1 471 ? 36.73800 -10.73500 15.59400 1.000 32.88280 ? 465 LEU A N   1 
ATOM   3438 C  CA  . LEU A 1 471 ? 38.09900 -10.48200 15.13900 1.000 35.30057 ? 465 LEU A CA  1 
ATOM   3439 C  C   . LEU A 1 471 ? 38.17500 -10.09200 13.66600 1.000 38.06919 ? 465 LEU A C   1 
ATOM   3440 O  O   . LEU A 1 471 ? 38.99000 -9.24200  13.29200 1.000 37.55638 ? 465 LEU A O   1 
ATOM   3441 C  CB  . LEU A 1 471 ? 38.95800 -11.72700 15.37800 1.000 38.95102 ? 465 LEU A CB  1 
ATOM   3442 C  CG  . LEU A 1 471 ? 40.34500 -11.71500 14.75100 1.000 42.27466 ? 465 LEU A CG  1 
ATOM   3443 C  CD1 . LEU A 1 471 ? 41.26500 -10.75200 15.48800 1.000 42.31851 ? 465 LEU A CD1 1 
ATOM   3444 C  CD2 . LEU A 1 471 ? 40.89800 -13.10400 14.79800 1.000 45.96657 ? 465 LEU A CD2 1 
ATOM   3445 N  N   . THR A 1 472 ? 37.33200 -10.68300 12.82600 1.000 33.72886 ? 466 THR A N   1 
ATOM   3446 C  CA  . THR A 1 472 ? 37.40500 -10.41200 11.39100 1.000 42.97127 ? 466 THR A CA  1 
ATOM   3447 C  C   . THR A 1 472 ? 37.24200 -8.93500  11.02600 1.000 42.81637 ? 466 THR A C   1 
ATOM   3448 O  O   . THR A 1 472 ? 37.87500 -8.50600  10.04500 1.000 40.19453 ? 466 THR A O   1 
ATOM   3449 C  CB  . THR A 1 472 ? 36.35900 -11.25900 10.66000 1.000 37.55123 ? 466 THR A CB  1 
ATOM   3450 O  OG1 . THR A 1 472 ? 36.34700 -12.57000 11.22900 1.000 43.95256 ? 466 THR A OG1 1 
ATOM   3451 C  CG2 . THR A 1 472 ? 36.71100 -11.37300 9.17600  1.000 38.55533 ? 466 THR A CG2 1 
ATOM   3452 N  N   . PRO A 1 473 ? 36.42700 -8.12300  11.71700 1.000 43.28015 ? 467 PRO A N   1 
ATOM   3453 C  CA  . PRO A 1 473 ? 36.35600 -6.70100  11.33400 1.000 36.09661 ? 467 PRO A CA  1 
ATOM   3454 C  C   . PRO A 1 473 ? 37.67500 -5.95600  11.47200 1.000 39.90664 ? 467 PRO A C   1 
ATOM   3455 O  O   . PRO A 1 473 ? 38.03000 -5.19300  10.56400 1.000 41.31749 ? 467 PRO A O   1 
ATOM   3456 C  CB  . PRO A 1 473 ? 35.27400 -6.15200  12.27000 1.000 39.78428 ? 467 PRO A CB  1 
ATOM   3457 C  CG  . PRO A 1 473 ? 34.38300 -7.34600  12.49300 1.000 35.79502 ? 467 PRO A CG  1 
ATOM   3458 C  CD  . PRO A 1 473 ? 35.33000 -8.47700  12.64400 1.000 30.03832 ? 467 PRO A CD  1 
ATOM   3459 N  N   . THR A 1 474 ? 38.42700 -6.16300  12.55400 1.000 38.19998 ? 468 THR A N   1 
ATOM   3460 C  CA  . THR A 1 474 ? 39.68600 -5.44000  12.70600 1.000 37.33837 ? 468 THR A CA  1 
ATOM   3461 C  C   . THR A 1 474 ? 40.75200 -5.95900  11.74300 1.000 48.79410 ? 468 THR A C   1 
ATOM   3462 O  O   . THR A 1 474 ? 41.58400 -5.18000  11.25900 1.000 41.06009 ? 468 THR A O   1 
ATOM   3463 C  CB  . THR A 1 474 ? 40.20900 -5.52100  14.14400 1.000 39.99580 ? 468 THR A CB  1 
ATOM   3464 O  OG1 . THR A 1 474 ? 40.47800 -6.88300  14.49000 1.000 40.48261 ? 468 THR A OG1 1 
ATOM   3465 C  CG2 . THR A 1 474 ? 39.20900 -4.94600  15.12800 1.000 39.90960 ? 468 THR A CG2 1 
ATOM   3466 N  N   . SER A 1 475 ? 40.77800 -7.27000  11.47200 1.000 42.00859 ? 469 SER A N   1 
ATOM   3467 C  CA  . SER A 1 475 ? 41.81900 -7.75400  10.57200 1.000 43.36030 ? 469 SER A CA  1 
ATOM   3468 C  C   . SER A 1 475 ? 41.48800 -7.42300  9.12000  1.000 40.20017 ? 469 SER A C   1 
ATOM   3469 O  O   . SER A 1 475 ? 42.40200 -7.20200  8.32000  1.000 47.80744 ? 469 SER A O   1 
ATOM   3470 C  CB  . SER A 1 475 ? 42.06300 -9.25600  10.77700 1.000 39.80079 ? 469 SER A CB  1 
ATOM   3471 O  OG  . SER A 1 475 ? 40.91100 -10.02900 10.51100 1.000 48.35196 ? 469 SER A OG  1 
ATOM   3472 N  N   . ALA A 1 476 ? 40.20000 -7.33800  8.78100  1.000 36.34093 ? 470 ALA A N   1 
ATOM   3473 C  CA  . ALA A 1 476 ? 39.79800 -6.85100  7.46800  1.000 39.04706 ? 470 ALA A CA  1 
ATOM   3474 C  C   . ALA A 1 476 ? 40.17800 -5.38600  7.28500  1.000 47.74533 ? 470 ALA A C   1 
ATOM   3475 O  O   . ALA A 1 476 ? 40.66500 -4.98800  6.22200  1.000 42.46194 ? 470 ALA A O   1 
ATOM   3476 C  CB  . ALA A 1 476 ? 38.29200 -7.03200  7.27600  1.000 38.36934 ? 470 ALA A CB  1 
ATOM   3477 N  N   . ILE A 1 477 ? 39.93300 -4.55900  8.30600  1.000 41.99359 ? 471 ILE A N   1 
ATOM   3478 C  CA  . ILE A 1 477 ? 40.32100 -3.15400  8.23200  1.000 47.08360 ? 471 ILE A CA  1 
ATOM   3479 C  C   . ILE A 1 477 ? 41.83400 -3.02200  8.07900  1.000 48.91551 ? 471 ILE A C   1 
ATOM   3480 O  O   . ILE A 1 477 ? 42.31900 -2.20100  7.28900  1.000 46.85627 ? 471 ILE A O   1 
ATOM   3481 C  CB  . ILE A 1 477 ? 39.79300 -2.39100  9.46300  1.000 38.62498 ? 471 ILE A CB  1 
ATOM   3482 C  CG1 . ILE A 1 477 ? 38.26900 -2.30700  9.38700  1.000 42.23773 ? 471 ILE A CG1 1 
ATOM   3483 C  CG2 . ILE A 1 477 ? 40.40500 -1.00400  9.55200  1.000 41.12236 ? 471 ILE A CG2 1 
ATOM   3484 C  CD1 . ILE A 1 477 ? 37.65400 -1.43800  10.44500 1.000 46.34508 ? 471 ILE A CD1 1 
ATOM   3485 N  N   . MET A 1 478 ? 42.60000 -3.84100  8.81000  1.000 46.85541 ? 472 MET A N   1 
ATOM   3486 C  CA  . MET A 1 478 ? 44.06000 -3.77500  8.72500  1.000 50.79360 ? 472 MET A CA  1 
ATOM   3487 C  C   . MET A 1 478 ? 44.55700 -4.13800  7.33000  1.000 49.53087 ? 472 MET A C   1 
ATOM   3488 O  O   . MET A 1 478 ? 45.45200 -3.47800  6.78700  1.000 51.60361 ? 472 MET A O   1 
ATOM   3489 C  CB  . MET A 1 478 ? 44.69800 -4.70500  9.76200  1.000 50.60892 ? 472 MET A CB  1 
ATOM   3490 C  CG  . MET A 1 478 ? 44.82800 -4.15900  11.18700 1.000 60.45240 ? 472 MET A CG  1 
ATOM   3491 S  SD  . MET A 1 478 ? 44.87600 -2.36100  11.39000 1.000 74.65235 ? 472 MET A SD  1 
ATOM   3492 C  CE  . MET A 1 478 ? 46.54500 -1.97400  10.85900 1.000 55.63541 ? 472 MET A CE  1 
ATOM   3493 N  N   . GLY A 1 479 ? 43.99200 -5.19400  6.73700  1.000 47.28312 ? 473 GLY A N   1 
ATOM   3494 C  CA  . GLY A 1 479 ? 44.44700 -5.66600  5.44500  1.000 49.81672 ? 473 GLY A CA  1 
ATOM   3495 C  C   . GLY A 1 479 ? 44.01100 -4.82000  4.27300  1.000 52.37281 ? 473 GLY A C   1 
ATOM   3496 O  O   . GLY A 1 479 ? 44.59900 -4.93500  3.19400  1.000 49.74521 ? 473 GLY A O   1 
ATOM   3497 N  N   . ALA A 1 480 ? 42.98700 -3.98600  4.44500  1.000 48.72918 ? 474 ALA A N   1 
ATOM   3498 C  CA  . ALA A 1 480 ? 42.61500 -3.02500  3.41700  1.000 49.93035 ? 474 ALA A CA  1 
ATOM   3499 C  C   . ALA A 1 480 ? 43.39800 -1.71800  3.53300  1.000 46.88475 ? 474 ALA A C   1 
ATOM   3500 O  O   . ALA A 1 480 ? 43.08600 -0.76000  2.81900  1.000 48.27854 ? 474 ALA A O   1 
ATOM   3501 C  CB  . ALA A 1 480 ? 41.10600 -2.74700  3.46300  1.000 39.24793 ? 474 ALA A CB  1 
ATOM   3502 N  N   . GLY A 1 481 ? 44.40000 -1.66100  4.40800  1.000 46.93454 ? 475 GLY A N   1 
ATOM   3503 C  CA  . GLY A 1 481 ? 45.16600 -0.44500  4.60000  1.000 47.33594 ? 475 GLY A CA  1 
ATOM   3504 C  C   . GLY A 1 481 ? 44.44400 0.66700   5.33200  1.000 47.79703 ? 475 GLY A C   1 
ATOM   3505 O  O   . GLY A 1 481 ? 44.89900 1.81100   5.29200  1.000 49.92273 ? 475 GLY A O   1 
ATOM   3506 N  N   . LEU A 1 482 ? 43.34000 0.36500   6.01800  1.000 43.43385 ? 476 LEU A N   1 
ATOM   3507 C  CA  . LEU A 1 482 ? 42.48400 1.37800   6.61900  1.000 39.50781 ? 476 LEU A CA  1 
ATOM   3508 C  C   . LEU A 1 482 ? 42.67700 1.53700   8.12200  1.000 43.15267 ? 476 LEU A C   1 
ATOM   3509 O  O   . LEU A 1 482 ? 41.87200 2.22300   8.75900  1.000 36.32173 ? 476 LEU A O   1 
ATOM   3510 C  CB  . LEU A 1 482 ? 41.02300 1.06300   6.32300  1.000 37.25230 ? 476 LEU A CB  1 
ATOM   3511 C  CG  . LEU A 1 482 ? 40.68200 1.08800   4.84100  1.000 43.27773 ? 476 LEU A CG  1 
ATOM   3512 C  CD1 . LEU A 1 482 ? 39.24700 0.65400   4.61700  1.000 40.83393 ? 476 LEU A CD1 1 
ATOM   3513 C  CD2 . LEU A 1 482 ? 40.93300 2.47900   4.29900  1.000 41.59348 ? 476 LEU A CD2 1 
ATOM   3514 N  N   . GLY A 1 483 ? 43.73700 0.95300   8.69000  1.000 36.68071 ? 477 GLY A N   1 
ATOM   3515 C  CA  . GLY A 1 483 ? 43.95900 0.91800   10.12400 1.000 44.75709 ? 477 GLY A CA  1 
ATOM   3516 C  C   . GLY A 1 483 ? 43.77200 2.21600   10.88500 1.000 46.58719 ? 477 GLY A C   1 
ATOM   3517 O  O   . GLY A 1 483 ? 42.89800 2.30800   11.75100 1.000 52.16254 ? 477 GLY A O   1 
ATOM   3518 N  N   . LYS A 1 484 ? 44.58800 3.22200   10.60000 1.000 41.82281 ? 478 LYS A N   1 
ATOM   3519 C  CA  . LYS A 1 484 ? 44.44300 4.50700   11.26800 1.000 45.98337 ? 478 LYS A CA  1 
ATOM   3520 C  C   . LYS A 1 484 ? 43.44000 5.42100   10.56800 1.000 41.00706 ? 478 LYS A C   1 
ATOM   3521 O  O   . LYS A 1 484 ? 43.29500 6.57700   10.97000 1.000 46.56877 ? 478 LYS A O   1 
ATOM   3522 C  CB  . LYS A 1 484 ? 45.79600 5.21500   11.37300 1.000 50.73897 ? 478 LYS A CB  1 
ATOM   3523 C  CG  . LYS A 1 484 ? 46.78500 4.60200   12.35700 1.000 54.58821 ? 478 LYS A CG  1 
ATOM   3524 C  CD  . LYS A 1 484 ? 47.63300 3.52600   11.69600 1.000 61.74054 ? 478 LYS A CD  1 
ATOM   3525 C  CE  . LYS A 1 484 ? 48.98500 3.37500   12.40000 1.000 69.79847 ? 478 LYS A CE  1 
ATOM   3526 N  NZ  . LYS A 1 484 ? 49.57600 2.00100   12.25600 1.000 68.58263 ? 478 LYS A NZ  1 
ATOM   3527 N  N   . GLU A 1 485 ? 42.73800 4.92300   9.54700  1.000 34.72869 ? 479 GLU A N   1 
ATOM   3528 C  CA  . GLU A 1 485 ? 41.90000 5.73900   8.68200  1.000 33.07234 ? 479 GLU A CA  1 
ATOM   3529 C  C   . GLU A 1 485 ? 40.41200 5.60000   8.97700  1.000 36.98917 ? 479 GLU A C   1 
ATOM   3530 O  O   . GLU A 1 485 ? 39.59000 6.22600   8.29600  1.000 29.44631 ? 479 GLU A O   1 
ATOM   3531 C  CB  . GLU A 1 485 ? 42.18700 5.38700   7.21800  1.000 33.15964 ? 479 GLU A CB  1 
ATOM   3532 C  CG  . GLU A 1 485 ? 43.59200 5.80700   6.79000  1.000 34.99815 ? 479 GLU A CG  1 
ATOM   3533 C  CD  . GLU A 1 485 ? 43.90800 5.48000   5.32500  1.000 43.20393 ? 479 GLU A CD  1 
ATOM   3534 O  OE1 . GLU A 1 485 ? 43.01900 5.00200   4.59100  1.000 42.66043 ? 479 GLU A OE1 1 
ATOM   3535 O  OE2 . GLU A 1 485 ? 45.05900 5.70000   4.90800  1.000 54.64557 ? 479 GLU A OE2 1 
ATOM   3536 N  N   . CYS A 1 486 ? 40.03900 4.79700   9.96700  1.000 31.98067 ? 480 CYS A N   1 
ATOM   3537 C  CA  . CYS A 1 486 ? 38.64200 4.71700   10.36000 1.000 32.75669 ? 480 CYS A CA  1 
ATOM   3538 C  C   . CYS A 1 486 ? 38.60700 4.25600   11.80700 1.000 30.71452 ? 480 CYS A C   1 
ATOM   3539 O  O   . CYS A 1 486 ? 39.60700 3.78000   12.34000 1.000 31.70180 ? 480 CYS A O   1 
ATOM   3540 C  CB  . CYS A 1 486 ? 37.83500 3.78400   9.44000  1.000 32.88892 ? 480 CYS A CB  1 
ATOM   3541 S  SG  . CYS A 1 486 ? 38.25600 2.03200   9.57800  1.000 40.84239 ? 480 CYS A SG  1 
ATOM   3542 N  N   . ALA A 1 487 ? 37.46600 4.46800   12.45100 1.000 31.78535 ? 481 ALA A N   1 
ATOM   3543 C  CA  . ALA A 1 487 ? 37.24200 4.00200   13.81100 1.000 29.81097 ? 481 ALA A CA  1 
ATOM   3544 C  C   . ALA A 1 487 ? 36.20700 2.88200   13.79200 1.000 32.10481 ? 481 ALA A C   1 
ATOM   3545 O  O   . ALA A 1 487 ? 35.40600 2.76800   12.85800 1.000 30.92870 ? 481 ALA A O   1 
ATOM   3546 C  CB  . ALA A 1 487 ? 36.76700 5.14700   14.71000 1.000 25.44604 ? 481 ALA A CB  1 
ATOM   3547 N  N   . LEU A 1 488 ? 36.22200 2.06300   14.84500 1.000 29.58553 ? 482 LEU A N   1 
ATOM   3548 C  CA  . LEU A 1 488 ? 35.34300 0.89800   14.95900 1.000 29.89258 ? 482 LEU A CA  1 
ATOM   3549 C  C   . LEU A 1 488 ? 34.60300 0.95400   16.29000 1.000 27.15104 ? 482 LEU A C   1 
ATOM   3550 O  O   . LEU A 1 488 ? 35.24300 1.04000   17.34300 1.000 25.29269 ? 482 LEU A O   1 
ATOM   3551 C  CB  . LEU A 1 488 ? 36.16000 -0.39300  14.87300 1.000 30.36754 ? 482 LEU A CB  1 
ATOM   3552 C  CG  . LEU A 1 488 ? 36.03000 -1.33700  13.68700 1.000 40.43348 ? 482 LEU A CG  1 
ATOM   3553 C  CD1 . LEU A 1 488 ? 36.80300 -2.61300  14.00900 1.000 35.77024 ? 482 LEU A CD1 1 
ATOM   3554 C  CD2 . LEU A 1 488 ? 34.57100 -1.64000  13.35600 1.000 34.03633 ? 482 LEU A CD2 1 
ATOM   3555 N  N   . LEU A 1 489 ? 33.26400 0.89900   16.24800 1.000 25.95401 ? 483 LEU A N   1 
ATOM   3556 C  CA  . LEU A 1 489 ? 32.42100 0.93400   17.44600 1.000 24.99418 ? 483 LEU A CA  1 
ATOM   3557 C  C   . LEU A 1 489 ? 31.46900 -0.25500  17.46200 1.000 28.29524 ? 483 LEU A C   1 
ATOM   3558 O  O   . LEU A 1 489 ? 30.89200 -0.59300  16.42500 1.000 25.70994 ? 483 LEU A O   1 
ATOM   3559 C  CB  . LEU A 1 489 ? 31.56900 2.20400   17.51100 1.000 24.95793 ? 483 LEU A CB  1 
ATOM   3560 C  CG  . LEU A 1 489 ? 32.25200 3.56900   17.40900 1.000 23.98406 ? 483 LEU A CG  1 
ATOM   3561 C  CD1 . LEU A 1 489 ? 31.21300 4.64800   17.56400 1.000 26.56779 ? 483 LEU A CD1 1 
ATOM   3562 C  CD2 . LEU A 1 489 ? 33.35000 3.67900   18.46800 1.000 23.39181 ? 483 LEU A CD2 1 
ATOM   3563 N  N   . THR A 1 490 ? 31.25100 -0.85200  18.64100 1.000 23.23843 ? 484 THR A N   1 
ATOM   3564 C  CA  . THR A 1 490 ? 30.26900 -1.92900  18.72300 1.000 25.24263 ? 484 THR A CA  1 
ATOM   3565 C  C   . THR A 1 490 ? 29.65800 -2.01400  20.11400 1.000 22.54920 ? 484 THR A C   1 
ATOM   3566 O  O   . THR A 1 490 ? 30.25900 -1.60800  21.11500 1.000 24.87985 ? 484 THR A O   1 
ATOM   3567 C  CB  . THR A 1 490 ? 30.87600 -3.29000  18.35300 1.000 26.47044 ? 484 THR A CB  1 
ATOM   3568 O  OG1 . THR A 1 490 ? 29.82500 -4.26700  18.28400 1.000 24.59084 ? 484 THR A OG1 1 
ATOM   3569 C  CG2 . THR A 1 490 ? 31.89700 -3.74900  19.39900 1.000 23.62906 ? 484 THR A CG2 1 
ATOM   3570 N  N   . ASP A 1 491 ? 28.44800 -2.56800  20.16800 1.000 24.22140 ? 485 ASP A N   1 
ATOM   3571 C  CA  . ASP A 1 491 ? 27.86800 -2.96500  21.44400 1.000 23.18222 ? 485 ASP A CA  1 
ATOM   3572 C  C   . ASP A 1 491 ? 28.26700 -4.38600  21.83400 1.000 24.70718 ? 485 ASP A C   1 
ATOM   3573 O  O   . ASP A 1 491 ? 27.90800 -4.84400  22.92800 1.000 24.44912 ? 485 ASP A O   1 
ATOM   3574 C  CB  . ASP A 1 491 ? 26.33200 -2.81800  21.42400 1.000 25.47970 ? 485 ASP A CB  1 
ATOM   3575 C  CG  . ASP A 1 491 ? 25.66800 -3.45000  20.19800 1.000 22.31455 ? 485 ASP A CG  1 
ATOM   3576 O  OD1 . ASP A 1 491 ? 26.34800 -4.12300  19.39700 1.000 23.49270 ? 485 ASP A OD1 1 
ATOM   3577 O  OD2 . ASP A 1 491 ? 24.43600 -3.25800  20.04200 1.000 23.27532 ? 485 ASP A OD2 1 
ATOM   3578 N  N   . GLY A 1 492 ? 29.01100 -5.07300  20.97700 1.000 24.13603 ? 486 GLY A N   1 
ATOM   3579 C  CA  . GLY A 1 492 ? 29.63200 -6.35400  21.27700 1.000 21.42335 ? 486 GLY A CA  1 
ATOM   3580 C  C   . GLY A 1 492 ? 31.05900 -6.16900  21.74800 1.000 22.27938 ? 486 GLY A C   1 
ATOM   3581 O  O   . GLY A 1 492 ? 31.37300 -5.22400  22.48400 1.000 22.06169 ? 486 GLY A O   1 
ATOM   3582 N  N   . ARG A 1 493 ? 31.94400 -7.05200  21.29200 1.000 22.32424 ? 487 ARG A N   1 
ATOM   3583 C  CA  . ARG A 1 493 ? 33.34500 -6.99600  21.69000 1.000 21.94893 ? 487 ARG A CA  1 
ATOM   3584 C  C   . ARG A 1 493 ? 34.23200 -7.22800  20.47600 1.000 27.13332 ? 487 ARG A C   1 
ATOM   3585 O  O   . ARG A 1 493 ? 33.90400 -8.03500  19.59900 1.000 29.07733 ? 487 ARG A O   1 
ATOM   3586 C  CB  . ARG A 1 493 ? 33.67800 -8.04500  22.77400 1.000 21.15072 ? 487 ARG A CB  1 
ATOM   3587 C  CG  . ARG A 1 493 ? 32.78500 -7.98100  24.03600 1.000 24.02415 ? 487 ARG A CG  1 
ATOM   3588 C  CD  . ARG A 1 493 ? 33.10600 -9.11100  25.04100 1.000 22.18244 ? 487 ARG A CD  1 
ATOM   3589 N  NE  . ARG A 1 493 ? 32.56100 -10.40400 24.62000 1.000 23.38500 ? 487 ARG A NE  1 
ATOM   3590 C  CZ  . ARG A 1 493 ? 33.14000 -11.57800 24.85000 1.000 27.48744 ? 487 ARG A CZ  1 
ATOM   3591 N  NH1 . ARG A 1 493 ? 34.27900 -11.67200 25.52600 1.000 26.20256 ? 487 ARG A NH1 1 
ATOM   3592 N  NH2 . ARG A 1 493 ? 32.56400 -12.68700 24.39000 1.000 27.71636 ? 487 ARG A NH2 1 
ATOM   3593 N  N   . PHE A 1 494 ? 35.37200 -6.54200  20.44500 1.000 27.83956 ? 488 PHE A N   1 
ATOM   3594 C  CA  . PHE A 1 494 ? 36.39500 -6.75200  19.43000 1.000 30.73895 ? 488 PHE A CA  1 
ATOM   3595 C  C   . PHE A 1 494 ? 37.59900 -7.43000  20.05900 1.000 31.61378 ? 488 PHE A C   1 
ATOM   3596 O  O   . PHE A 1 494 ? 37.92600 -7.18700  21.22500 1.000 34.43364 ? 488 PHE A O   1 
ATOM   3597 C  CB  . PHE A 1 494 ? 36.81300 -5.42400  18.78800 1.000 27.88577 ? 488 PHE A CB  1 
ATOM   3598 C  CG  . PHE A 1 494 ? 35.78400 -4.86400  17.86500 1.000 28.37203 ? 488 PHE A CG  1 
ATOM   3599 C  CD1 . PHE A 1 494 ? 35.29100 -5.62500  16.81200 1.000 29.28006 ? 488 PHE A CD1 1 
ATOM   3600 C  CD2 . PHE A 1 494 ? 35.28500 -3.58600  18.05400 1.000 25.38980 ? 488 PHE A CD2 1 
ATOM   3601 C  CE1 . PHE A 1 494 ? 34.34200 -5.11600  15.96000 1.000 29.98621 ? 488 PHE A CE1 1 
ATOM   3602 C  CE2 . PHE A 1 494 ? 34.33400 -3.06100  17.18600 1.000 27.59941 ? 488 PHE A CE2 1 
ATOM   3603 C  CZ  . PHE A 1 494 ? 33.85300 -3.82200  16.15200 1.000 28.75977 ? 488 PHE A CZ  1 
ATOM   3604 N  N   . SER A 1 495 ? 38.26500 -8.28500  19.28400 1.000 37.07228 ? 489 SER A N   1 
ATOM   3605 C  CA  . SER A 1 495 ? 39.36000 -9.09400  19.81500 1.000 43.66039 ? 489 SER A CA  1 
ATOM   3606 C  C   . SER A 1 495 ? 40.73900 -8.53800  19.47000 1.000 51.33818 ? 489 SER A C   1 
ATOM   3607 O  O   . SER A 1 495 ? 41.50900 -8.18500  20.37100 1.000 54.26365 ? 489 SER A O   1 
ATOM   3608 C  CB  . SER A 1 495 ? 39.22100 -10.53300 19.31700 1.000 41.63328 ? 489 SER A CB  1 
ATOM   3609 O  OG  . SER A 1 495 ? 38.20200 -11.17500 20.05800 1.000 51.88685 ? 489 SER A OG  1 
ATOM   3610 N  N   . GLY A 1 496 ? 41.07100 -8.47400  18.17900 1.000 47.26177 ? 490 GLY A N   1 
ATOM   3611 C  CA  . GLY A 1 496 ? 42.37500 -8.00000  17.77300 1.000 52.90679 ? 490 GLY A CA  1 
ATOM   3612 C  C   . GLY A 1 496 ? 42.49400 -6.49100  17.84100 1.000 59.10961 ? 490 GLY A C   1 
ATOM   3613 O  O   . GLY A 1 496 ? 41.51300 -5.75200  17.93100 1.000 59.56401 ? 490 GLY A O   1 
ATOM   3614 N  N   . GLY A 1 497 ? 43.73900 -6.02200  17.80700 1.000 66.60965 ? 491 GLY A N   1 
ATOM   3615 C  CA  . GLY A 1 497 ? 44.01500 -4.60300  17.89600 1.000 60.93428 ? 491 GLY A CA  1 
ATOM   3616 C  C   . GLY A 1 497 ? 44.08700 -3.97200  16.52100 1.000 64.11798 ? 491 GLY A C   1 
ATOM   3617 O  O   . GLY A 1 497 ? 44.75100 -4.49200  15.62000 1.000 62.77045 ? 491 GLY A O   1 
ATOM   3618 N  N   . SER A 1 498 ? 43.35700 -2.87600  16.35000 1.000 66.97579 ? 492 SER A N   1 
ATOM   3619 C  CA  . SER A 1 498 ? 43.63400 -1.95800  15.26200 1.000 63.16574 ? 492 SER A CA  1 
ATOM   3620 C  C   . SER A 1 498 ? 44.78700 -1.04900  15.67100 1.000 62.63048 ? 492 SER A C   1 
ATOM   3621 O  O   . SER A 1 498 ? 45.25500 -1.06200  16.81400 1.000 65.49356 ? 492 SER A O   1 
ATOM   3622 C  CB  . SER A 1 498 ? 42.38400 -1.14000  14.91800 1.000 52.46162 ? 492 SER A CB  1 
ATOM   3623 O  OG  . SER A 1 498 ? 42.57500 -0.25600  13.82700 1.000 52.65792 ? 492 SER A OG  1 
ATOM   3624 N  N   . HIS A 1 499 ? 45.26900 -0.27100  14.71800 1.000 55.31320 ? 493 HIS A N   1 
ATOM   3625 C  CA  . HIS A 1 499 ? 46.16600 0.81600   15.04300 1.000 55.06975 ? 493 HIS A CA  1 
ATOM   3626 C  C   . HIS A 1 499 ? 45.41200 2.12900   15.20500 1.000 55.76355 ? 493 HIS A C   1 
ATOM   3627 O  O   . HIS A 1 499 ? 46.03900 3.19100   15.28900 1.000 53.65834 ? 493 HIS A O   1 
ATOM   3628 C  CB  . HIS A 1 499 ? 47.25100 0.91700   13.97700 1.000 60.02387 ? 493 HIS A CB  1 
ATOM   3629 N  N   . GLY A 1 500 ? 44.07700 2.06200   15.25700 1.000 50.22482 ? 494 GLY A N   1 
ATOM   3630 C  CA  . GLY A 1 500 ? 43.21100 3.20400   15.47400 1.000 46.69307 ? 494 GLY A CA  1 
ATOM   3631 C  C   . GLY A 1 500 ? 42.24800 2.99600   16.62800 1.000 43.17419 ? 494 GLY A C   1 
ATOM   3632 O  O   . GLY A 1 500 ? 42.49700 2.17500   17.51500 1.000 46.41625 ? 494 GLY A O   1 
ATOM   3633 N  N   . PHE A 1 501 ? 41.14600 3.73900   16.63600 1.000 35.11178 ? 495 PHE A N   1 
ATOM   3634 C  CA  . PHE A 1 501 ? 40.20500 3.68400   17.74500 1.000 34.47199 ? 495 PHE A CA  1 
ATOM   3635 C  C   . PHE A 1 501 ? 39.25400 2.50600   17.58300 1.000 35.21101 ? 495 PHE A C   1 
ATOM   3636 O  O   . PHE A 1 501 ? 38.59200 2.36000   16.55200 1.000 27.83543 ? 495 PHE A O   1 
ATOM   3637 C  CB  . PHE A 1 501 ? 39.41400 4.98100   17.83500 1.000 36.20240 ? 495 PHE A CB  1 
ATOM   3638 C  CG  . PHE A 1 501 ? 40.26700 6.20500   18.08400 1.000 39.69180 ? 495 PHE A CG  1 
ATOM   3639 C  CD1 . PHE A 1 501 ? 40.54400 6.62000   19.37500 1.000 43.62555 ? 495 PHE A CD1 1 
ATOM   3640 C  CD2 . PHE A 1 501 ? 40.79600 6.92600   17.02900 1.000 38.08641 ? 495 PHE A CD2 1 
ATOM   3641 C  CE1 . PHE A 1 501 ? 41.32100 7.74800   19.60500 1.000 40.86605 ? 495 PHE A CE1 1 
ATOM   3642 C  CE2 . PHE A 1 501 ? 41.57700 8.04500   17.25300 1.000 42.80617 ? 495 PHE A CE2 1 
ATOM   3643 C  CZ  . PHE A 1 501 ? 41.83600 8.45800   18.54400 1.000 41.17279 ? 495 PHE A CZ  1 
ATOM   3644 N  N   . VAL A 1 502 ? 39.18100 1.66800   18.60900 1.000 27.00822 ? 496 VAL A N   1 
ATOM   3645 C  CA  . VAL A 1 502 ? 38.32100 0.49500   18.58800 1.000 27.64510 ? 496 VAL A CA  1 
ATOM   3646 C  C   . VAL A 1 502 ? 37.62200 0.45100   19.94100 1.000 28.87469 ? 496 VAL A C   1 
ATOM   3647 O  O   . VAL A 1 502 ? 38.29100 0.37600   20.97200 1.000 26.04665 ? 496 VAL A O   1 
ATOM   3648 C  CB  . VAL A 1 502 ? 39.12000 -0.79100  18.33800 1.000 29.75714 ? 496 VAL A CB  1 
ATOM   3649 C  CG1 . VAL A 1 502 ? 38.23700 -2.03100  18.51200 1.000 31.27677 ? 496 VAL A CG1 1 
ATOM   3650 C  CG2 . VAL A 1 502 ? 39.74600 -0.75600  16.95900 1.000 31.41681 ? 496 VAL A CG2 1 
ATOM   3651 N  N   . VAL A 1 503 ? 36.29600 0.57400   19.94900 1.000 25.06552 ? 497 VAL A N   1 
ATOM   3652 C  CA  . VAL A 1 503 ? 35.51700 0.64500   21.18400 1.000 26.71925 ? 497 VAL A CA  1 
ATOM   3653 C  C   . VAL A 1 503 ? 34.47900 -0.47400  21.18200 1.000 26.40290 ? 497 VAL A C   1 
ATOM   3654 O  O   . VAL A 1 503 ? 33.78400 -0.67600  20.17800 1.000 25.12298 ? 497 VAL A O   1 
ATOM   3655 C  CB  . VAL A 1 503 ? 34.83000 2.01300   21.35400 1.000 27.58984 ? 497 VAL A CB  1 
ATOM   3656 C  CG1 . VAL A 1 503 ? 34.18900 2.12700   22.74500 1.000 28.44055 ? 497 VAL A CG1 1 
ATOM   3657 C  CG2 . VAL A 1 503 ? 35.82800 3.16800   21.12100 1.000 25.21196 ? 497 VAL A CG2 1 
ATOM   3658 N  N   . GLY A 1 504 ? 34.37100 -1.19000  22.30800 1.000 25.17926 ? 498 GLY A N   1 
ATOM   3659 C  CA  . GLY A 1 504 ? 33.36000 -2.20900  22.50500 1.000 22.09419 ? 498 GLY A CA  1 
ATOM   3660 C  C   . GLY A 1 504 ? 32.51400 -1.91400  23.73500 1.000 27.67932 ? 498 GLY A C   1 
ATOM   3661 O  O   . GLY A 1 504 ? 32.67600 -0.88500  24.39600 1.000 24.51508 ? 498 GLY A O   1 
ATOM   3662 N  N   . HIS A 1 505 ? 31.59000 -2.84000  24.02700 1.000 23.91379 ? 499 HIS A N   1 
ATOM   3663 C  CA  . HIS A 1 505 ? 30.76600 -2.76900  25.24800 1.000 19.67216 ? 499 HIS A CA  1 
ATOM   3664 C  C   . HIS A 1 505 ? 29.90200 -1.51700  25.28800 1.000 23.84480 ? 499 HIS A C   1 
ATOM   3665 O  O   . HIS A 1 505 ? 29.58200 -1.02700  26.37400 1.000 23.72027 ? 499 HIS A O   1 
ATOM   3666 C  CB  . HIS A 1 505 ? 31.58500 -2.77800  26.54700 1.000 22.24206 ? 499 HIS A CB  1 
ATOM   3667 C  CG  . HIS A 1 505 ? 32.65400 -3.82600  26.62900 1.000 21.88889 ? 499 HIS A CG  1 
ATOM   3668 N  ND1 . HIS A 1 505 ? 33.20700 -4.21400  27.83600 1.000 19.79788 ? 499 HIS A ND1 1 
ATOM   3669 C  CD2 . HIS A 1 505 ? 33.29700 -4.54100  25.67200 1.000 23.42019 ? 499 HIS A CD2 1 
ATOM   3670 C  CE1 . HIS A 1 505 ? 34.14300 -5.12100  27.61500 1.000 17.54982 ? 499 HIS A CE1 1 
ATOM   3671 N  NE2 . HIS A 1 505 ? 34.20900 -5.34800  26.31400 1.000 21.00026 ? 499 HIS A NE2 1 
ATOM   3672 N  N   . ILE A 1 506 ? 29.51200 -0.96800  24.13700 1.000 25.95258 ? 500 ILE A N   1 
ATOM   3673 C  CA  . ILE A 1 506 ? 28.77200 0.29000   24.15800 1.000 24.03871 ? 500 ILE A CA  1 
ATOM   3674 C  C   . ILE A 1 506 ? 27.38100 0.05900   24.74100 1.000 25.75121 ? 500 ILE A C   1 
ATOM   3675 O  O   . ILE A 1 506 ? 26.65500 -0.85400  24.32500 1.000 22.48993 ? 500 ILE A O   1 
ATOM   3676 C  CB  . ILE A 1 506 ? 28.72200 0.91100   22.75400 1.000 22.19989 ? 500 ILE A CB  1 
ATOM   3677 C  CG1 . ILE A 1 506 ? 30.11000 1.48500   22.40800 1.000 23.78400 ? 500 ILE A CG1 1 
ATOM   3678 C  CG2 . ILE A 1 506 ? 27.62400 1.96400   22.68500 1.000 20.38747 ? 500 ILE A CG2 1 
ATOM   3679 C  CD1 . ILE A 1 506 ? 30.26200 2.00100   20.96900 1.000 18.16982 ? 500 ILE A CD1 1 
ATOM   3680 N  N   . CYS A 1 507 ? 27.02300 0.86900   25.74500 1.000 22.28069 ? 501 CYS A N   1 
ATOM   3681 C  CA  . CYS A 1 507 ? 25.81000 0.72300   26.53300 1.000 26.24468 ? 501 CYS A CA  1 
ATOM   3682 C  C   . CYS A 1 507 ? 25.03100 2.03000   26.60200 1.000 28.93010 ? 501 CYS A C   1 
ATOM   3683 O  O   . CYS A 1 507 ? 25.62500 3.10000   26.80900 1.000 27.84796 ? 501 CYS A O   1 
ATOM   3684 C  CB  . CYS A 1 507 ? 26.14000 0.25400   27.95600 1.000 25.13609 ? 501 CYS A CB  1 
ATOM   3685 S  SG  . CYS A 1 507 ? 26.48200 -1.49700  28.01100 1.000 25.97860 ? 501 CYS A SG  1 
ATOM   3686 N  N   . PRO A 1 508 ? 23.69000 1.96900   26.49100 1.000 26.91560 ? 502 PRO A N   1 
ATOM   3687 C  CA  . PRO A 1 508 ? 22.95900 0.70400   26.27700 1.000 26.57808 ? 502 PRO A CA  1 
ATOM   3688 C  C   . PRO A 1 508 ? 23.16300 0.10800   24.89000 1.000 28.31555 ? 502 PRO A C   1 
ATOM   3689 O  O   . PRO A 1 508 ? 23.44100 0.83600   23.92200 1.000 29.57660 ? 502 PRO A O   1 
ATOM   3690 C  CB  . PRO A 1 508 ? 21.48100 1.09800   26.47600 1.000 27.42496 ? 502 PRO A CB  1 
ATOM   3691 C  CG  . PRO A 1 508 ? 21.52300 2.38700   27.24000 1.000 27.74916 ? 502 PRO A CG  1 
ATOM   3692 C  CD  . PRO A 1 508 ? 22.77600 3.09000   26.76700 1.000 27.05351 ? 502 PRO A CD  1 
ATOM   3693 N  N   . GLU A 1 509 ? 23.05800 -1.21200  24.79100 1.000 21.39967 ? 503 GLU A N   1 
ATOM   3694 C  CA  . GLU A 1 509 ? 23.20900 -1.85300  23.49100 1.000 18.97729 ? 503 GLU A CA  1 
ATOM   3695 C  C   . GLU A 1 509 ? 22.04400 -1.48000  22.57100 1.000 22.78190 ? 503 GLU A C   1 
ATOM   3696 O  O   . GLU A 1 509 ? 21.00400 -0.97800  23.01100 1.000 24.81908 ? 503 GLU A O   1 
ATOM   3697 C  CB  . GLU A 1 509 ? 23.31900 -3.37300  23.65900 1.000 20.83564 ? 503 GLU A CB  1 
ATOM   3698 C  CG  . GLU A 1 509 ? 22.01700 -4.05800  24.12000 1.000 21.72266 ? 503 GLU A CG  1 
ATOM   3699 C  CD  . GLU A 1 509 ? 22.14100 -5.57300  24.07600 1.000 23.52377 ? 503 GLU A CD  1 
ATOM   3700 O  OE1 . GLU A 1 509 ? 22.35200 -6.12200  22.97300 1.000 19.93930 ? 503 GLU A OE1 1 
ATOM   3701 O  OE2 . GLU A 1 509 ? 22.02700 -6.21100  25.14800 1.000 23.35381 ? 503 GLU A OE2 1 
ATOM   3702 N  N   . ALA A 1 510 ? 22.24300 -1.72900  21.27100 1.000 23.56485 ? 504 ALA A N   1 
ATOM   3703 C  CA  . ALA A 1 510 ? 21.23200 -1.40200  20.26600 1.000 26.40620 ? 504 ALA A CA  1 
ATOM   3704 C  C   . ALA A 1 510 ? 19.90600 -2.12400  20.52600 1.000 32.87873 ? 504 ALA A C   1 
ATOM   3705 O  O   . ALA A 1 510 ? 18.82200 -1.53100  20.37600 1.000 28.64864 ? 504 ALA A O   1 
ATOM   3706 C  CB  . ALA A 1 510 ? 21.77400 -1.74000  18.87700 1.000 25.26371 ? 504 ALA A CB  1 
ATOM   3707 N  N   . GLN A 1 511 ? 19.97200 -3.40500  20.91900 1.000 32.46702 ? 505 GLN A N   1 
ATOM   3708 C  CA  . GLN A 1 511 ? 18.76400 -4.17800  21.21200 1.000 28.79755 ? 505 GLN A CA  1 
ATOM   3709 C  C   . GLN A 1 511 ? 17.94200 -3.53900  22.31200 1.000 28.55749 ? 505 GLN A C   1 
ATOM   3710 O  O   . GLN A 1 511 ? 16.71400 -3.67300  22.33200 1.000 32.59995 ? 505 GLN A O   1 
ATOM   3711 C  CB  . GLN A 1 511 ? 19.13200 -5.61100  21.61900 1.000 31.79643 ? 505 GLN A CB  1 
ATOM   3712 C  CG  . GLN A 1 511 ? 17.93000 -6.51400  21.91900 1.000 26.79485 ? 505 GLN A CG  1 
ATOM   3713 C  CD  . GLN A 1 511 ? 17.10600 -6.83800  20.68300 1.000 27.86050 ? 505 GLN A CD  1 
ATOM   3714 O  OE1 . GLN A 1 511 ? 17.64700 -7.10800  19.60000 1.000 28.56598 ? 505 GLN A OE1 1 
ATOM   3715 N  NE2 . GLN A 1 511 ? 15.78600 -6.84300  20.84600 1.000 30.28947 ? 505 GLN A NE2 1 
ATOM   3716 N  N   . GLU A 1 512 ? 18.59000 -2.85400  23.23700 1.000 26.46703 ? 506 GLU A N   1 
ATOM   3717 C  CA  . GLU A 1 512 ? 17.88900 -2.17500  24.31300 1.000 29.99245 ? 506 GLU A CA  1 
ATOM   3718 C  C   . GLU A 1 512 ? 17.51000 -0.74100  23.94900 1.000 28.41531 ? 506 GLU A C   1 
ATOM   3719 O  O   . GLU A 1 512 ? 17.07900 0.00700   24.82100 1.000 33.79394 ? 506 GLU A O   1 
ATOM   3720 C  CB  . GLU A 1 512 ? 18.74900 -2.18500  25.58000 1.000 30.00957 ? 506 GLU A CB  1 
ATOM   3721 C  CG  . GLU A 1 512 ? 18.96000 -3.57500  26.17600 1.000 33.52400 ? 506 GLU A CG  1 
ATOM   3722 C  CD  . GLU A 1 512 ? 17.67300 -4.19800  26.66800 1.000 35.28390 ? 506 GLU A CD  1 
ATOM   3723 O  OE1 . GLU A 1 512 ? 17.31900 -3.95100  27.83700 1.000 47.06652 ? 506 GLU A OE1 1 
ATOM   3724 O  OE2 . GLU A 1 512 ? 17.01600 -4.93100  25.88800 1.000 40.25996 ? 506 GLU A OE2 1 
ATOM   3725 N  N   . GLY A 1 513 ? 17.68900 -0.33600  22.69500 1.000 33.86569 ? 507 GLY A N   1 
ATOM   3726 C  CA  . GLY A 1 513 ? 17.32300 1.01700   22.32300 1.000 33.34042 ? 507 GLY A CA  1 
ATOM   3727 C  C   . GLY A 1 513 ? 18.26300 2.10500   22.78500 1.000 36.85077 ? 507 GLY A C   1 
ATOM   3728 O  O   . GLY A 1 513 ? 17.84400 3.26300   22.87700 1.000 32.05461 ? 507 GLY A O   1 
ATOM   3729 N  N   . GLY A 1 514 ? 19.51800 1.77100   23.09300 1.000 29.70602 ? 508 GLY A N   1 
ATOM   3730 C  CA  . GLY A 1 514 ? 20.54000 2.76800   23.32100 1.000 28.97623 ? 508 GLY A CA  1 
ATOM   3731 C  C   . GLY A 1 514 ? 20.79000 3.60900   22.07300 1.000 28.97707 ? 508 GLY A C   1 
ATOM   3732 O  O   . GLY A 1 514 ? 20.47000 3.19700   20.95100 1.000 27.17655 ? 508 GLY A O   1 
ATOM   3733 N  N   . PRO A 1 515 ? 21.37500 4.80500   22.24600 1.000 28.37979 ? 509 PRO A N   1 
ATOM   3734 C  CA  . PRO A 1 515 ? 21.62900 5.68100   21.08700 1.000 25.09743 ? 509 PRO A CA  1 
ATOM   3735 C  C   . PRO A 1 515 ? 22.34800 5.00000   19.93500 1.000 26.67910 ? 509 PRO A C   1 
ATOM   3736 O  O   . PRO A 1 515 ? 22.12300 5.38100   18.77900 1.000 26.63865 ? 509 PRO A O   1 
ATOM   3737 C  CB  . PRO A 1 515 ? 22.49200 6.79800   21.69000 1.000 27.91020 ? 509 PRO A CB  1 
ATOM   3738 C  CG  . PRO A 1 515 ? 22.02800 6.87500   23.10300 1.000 34.95745 ? 509 PRO A CG  1 
ATOM   3739 C  CD  . PRO A 1 515 ? 21.79900 5.43500   23.50600 1.000 23.76674 ? 509 PRO A CD  1 
ATOM   3740 N  N   . ILE A 1 516 ? 23.17600 3.98400   20.20300 1.000 25.94885 ? 510 ILE A N   1 
ATOM   3741 C  CA  . ILE A 1 516 ? 23.88200 3.29200   19.12500 1.000 24.03535 ? 510 ILE A CA  1 
ATOM   3742 C  C   . ILE A 1 516 ? 22.90800 2.68500   18.12500 1.000 26.19379 ? 510 ILE A C   1 
ATOM   3743 O  O   . ILE A 1 516 ? 23.21900 2.59700   16.93300 1.000 26.41990 ? 510 ILE A O   1 
ATOM   3744 C  CB  . ILE A 1 516 ? 24.84700 2.22000   19.67700 1.000 24.95166 ? 510 ILE A CB  1 
ATOM   3745 C  CG1 . ILE A 1 516 ? 25.72400 1.68600   18.54300 1.000 22.49918 ? 510 ILE A CG1 1 
ATOM   3746 C  CG2 . ILE A 1 516 ? 24.07600 1.04900   20.33600 1.000 25.79718 ? 510 ILE A CG2 1 
ATOM   3747 C  CD1 . ILE A 1 516 ? 26.77500 0.65900   18.98600 1.000 24.27017 ? 510 ILE A CD1 1 
ATOM   3748 N  N   . GLY A 1 517 ? 21.72100 2.25800   18.57600 1.000 25.85507 ? 511 GLY A N   1 
ATOM   3749 C  CA  . GLY A 1 517 ? 20.74800 1.72400   17.63700 1.000 27.75317 ? 511 GLY A CA  1 
ATOM   3750 C  C   . GLY A 1 517 ? 19.98300 2.76500   16.84100 1.000 32.61202 ? 511 GLY A C   1 
ATOM   3751 O  O   . GLY A 1 517 ? 19.19300 2.39800   15.96700 1.000 35.90323 ? 511 GLY A O   1 
ATOM   3752 N  N   . LEU A 1 518 ? 20.21400 4.05500   17.12100 1.000 33.37120 ? 512 LEU A N   1 
ATOM   3753 C  CA  . LEU A 1 518 ? 19.58600 5.18200   16.42900 1.000 33.33991 ? 512 LEU A CA  1 
ATOM   3754 C  C   . LEU A 1 518 ? 20.51400 5.88400   15.45400 1.000 35.27074 ? 512 LEU A C   1 
ATOM   3755 O  O   . LEU A 1 518 ? 20.06900 6.80300   14.76000 1.000 38.45050 ? 512 LEU A O   1 
ATOM   3756 C  CB  . LEU A 1 518 ? 19.09900 6.22600   17.44000 1.000 30.73416 ? 512 LEU A CB  1 
ATOM   3757 C  CG  . LEU A 1 518 ? 18.28000 5.74900   18.63400 1.000 35.21213 ? 512 LEU A CG  1 
ATOM   3758 C  CD1 . LEU A 1 518 ? 18.07300 6.90500   19.57800 1.000 33.00810 ? 512 LEU A CD1 1 
ATOM   3759 C  CD2 . LEU A 1 518 ? 16.95800 5.22800   18.14300 1.000 37.38808 ? 512 LEU A CD2 1 
ATOM   3760 N  N   . ILE A 1 519 ? 21.79400 5.50700   15.42000 1.000 28.66500 ? 513 ILE A N   1 
ATOM   3761 C  CA  . ILE A 1 519 ? 22.73400 6.09200   14.47400 1.000 34.34343 ? 513 ILE A CA  1 
ATOM   3762 C  C   . ILE A 1 519 ? 22.31400 5.77300   13.04600 1.000 33.05250 ? 513 ILE A C   1 
ATOM   3763 O  O   . ILE A 1 519 ? 21.91300 4.64700   12.73400 1.000 27.76379 ? 513 ILE A O   1 
ATOM   3764 C  CB  . ILE A 1 519 ? 24.15400 5.56900   14.75400 1.000 29.32003 ? 513 ILE A CB  1 
ATOM   3765 C  CG1 . ILE A 1 519 ? 24.57400 5.89200   16.18000 1.000 24.92983 ? 513 ILE A CG1 1 
ATOM   3766 C  CG2 . ILE A 1 519 ? 25.16000 6.14400   13.77200 1.000 29.83965 ? 513 ILE A CG2 1 
ATOM   3767 C  CD1 . ILE A 1 519 ? 25.90400 5.28900   16.56100 1.000 25.52037 ? 513 ILE A CD1 1 
ATOM   3768 N  N   . LYS A 1 520 ? 22.45300 6.76200   12.15600 1.000 32.05053 ? 514 LYS A N   1 
ATOM   3769 C  CA  . LYS A 1 520 ? 22.22800 6.57300   10.72700 1.000 32.96961 ? 514 LYS A CA  1 
ATOM   3770 C  C   . LYS A 1 520 ? 23.51000 6.84300   9.94500  1.000 30.49338 ? 514 LYS A C   1 
ATOM   3771 O  O   . LYS A 1 520 ? 24.36700 7.62600   10.37500 1.000 33.23172 ? 514 LYS A O   1 
ATOM   3772 C  CB  . LYS A 1 520 ? 21.10600 7.49700   10.21400 1.000 39.06330 ? 514 LYS A CB  1 
ATOM   3773 C  CG  . LYS A 1 520 ? 19.70300 7.12200   10.68300 1.000 38.72215 ? 514 LYS A CG  1 
ATOM   3774 C  CD  . LYS A 1 520 ? 18.66900 8.18200   10.26100 1.000 42.38121 ? 514 LYS A CD  1 
ATOM   3775 C  CE  . LYS A 1 520 ? 17.26600 7.59500   10.14400 1.000 52.32613 ? 514 LYS A CE  1 
ATOM   3776 N  NZ  . LYS A 1 520 ? 17.05400 6.80500   8.88000  1.000 68.89230 ? 514 LYS A NZ  1 
ATOM   3777 N  N   . ASN A 1 521 ? 23.65000 6.17100   8.80200  1.000 31.71855 ? 515 ASN A N   1 
ATOM   3778 C  CA  . ASN A 1 521 ? 24.75200 6.46300   7.89500  1.000 34.61326 ? 515 ASN A CA  1 
ATOM   3779 C  C   . ASN A 1 521 ? 24.83400 7.96600   7.64300  1.000 36.43629 ? 515 ASN A C   1 
ATOM   3780 O  O   . ASN A 1 521 ? 23.81800 8.62700   7.40400  1.000 30.51321 ? 515 ASN A O   1 
ATOM   3781 C  CB  . ASN A 1 521 ? 24.56800 5.71000   6.57300  1.000 37.57888 ? 515 ASN A CB  1 
ATOM   3782 C  CG  . ASN A 1 521 ? 24.98400 4.25400   6.66200  1.000 38.53478 ? 515 ASN A CG  1 
ATOM   3783 O  OD1 . ASN A 1 521 ? 25.42400 3.78600   7.70900  1.000 36.52310 ? 515 ASN A OD1 1 
ATOM   3784 N  ND2 . ASN A 1 521 ? 24.84700 3.53000   5.56100  1.000 35.16565 ? 515 ASN A ND2 1 
ATOM   3785 N  N   . GLY A 1 522 ? 26.04400 8.50500   7.74900  1.000 35.14999 ? 516 GLY A N   1 
ATOM   3786 C  CA  . GLY A 1 522 ? 26.29400 9.91000   7.54400  1.000 33.03807 ? 516 GLY A CA  1 
ATOM   3787 C  C   . GLY A 1 522 ? 26.37600 10.74000  8.80700  1.000 32.94692 ? 516 GLY A C   1 
ATOM   3788 O  O   . GLY A 1 522 ? 26.97700 11.81700  8.76900  1.000 32.74684 ? 516 GLY A O   1 
ATOM   3789 N  N   . ASP A 1 523 ? 25.77000 10.29700  9.91200  1.000 27.20348 ? 517 ASP A N   1 
ATOM   3790 C  CA  . ASP A 1 523 ? 25.92700 11.01200  11.17200 1.000 25.94778 ? 517 ASP A CA  1 
ATOM   3791 C  C   . ASP A 1 523 ? 27.41000 11.23700  11.42900 1.000 29.39336 ? 517 ASP A C   1 
ATOM   3792 O  O   . ASP A 1 523 ? 28.22100 10.32200  11.26100 1.000 33.71511 ? 517 ASP A O   1 
ATOM   3793 C  CB  . ASP A 1 523 ? 25.33100 10.21300  12.33600 1.000 34.67463 ? 517 ASP A CB  1 
ATOM   3794 C  CG  . ASP A 1 523 ? 23.81800 10.02600  12.24600 1.000 38.11701 ? 517 ASP A CG  1 
ATOM   3795 O  OD1 . ASP A 1 523 ? 23.17300 10.54100  11.30000 1.000 35.27428 ? 517 ASP A OD1 1 
ATOM   3796 O  OD2 . ASP A 1 523 ? 23.27100 9.38000   13.17300 1.000 32.18897 ? 517 ASP A OD2 1 
ATOM   3797 N  N   . ILE A 1 524 ? 27.78000 12.45600  11.80200 1.000 33.54908 ? 518 ILE A N   1 
ATOM   3798 C  CA  . ILE A 1 524 ? 29.18300 12.70700  12.13000 1.000 32.58752 ? 518 ILE A CA  1 
ATOM   3799 C  C   . ILE A 1 524 ? 29.42300 12.28800  13.57300 1.000 28.76851 ? 518 ILE A C   1 
ATOM   3800 O  O   . ILE A 1 524 ? 28.81700 12.83400  14.50200 1.000 29.12947 ? 518 ILE A O   1 
ATOM   3801 C  CB  . ILE A 1 524 ? 29.57600 14.17400  11.90500 1.000 32.58486 ? 518 ILE A CB  1 
ATOM   3802 C  CG1 . ILE A 1 524 ? 29.31300 14.57900  10.44800 1.000 30.89888 ? 518 ILE A CG1 1 
ATOM   3803 C  CG2 . ILE A 1 524 ? 31.03300 14.42100  12.34900 1.000 30.57927 ? 518 ILE A CG2 1 
ATOM   3804 C  CD1 . ILE A 1 524 ? 30.10000 13.79700  9.44900  1.000 29.29851 ? 518 ILE A CD1 1 
ATOM   3805 N  N   . ILE A 1 525 ? 30.32600 11.33100  13.76500 1.000 27.60915 ? 519 ILE A N   1 
ATOM   3806 C  CA  . ILE A 1 525 ? 30.64800 10.82700  15.09200 1.000 29.25840 ? 519 ILE A CA  1 
ATOM   3807 C  C   . ILE A 1 525 ? 32.03400 11.31000  15.46500 1.000 24.56168 ? 519 ILE A C   1 
ATOM   3808 O  O   . ILE A 1 525 ? 32.95500 11.29300  14.63900 1.000 28.79536 ? 519 ILE A O   1 
ATOM   3809 C  CB  . ILE A 1 525 ? 30.56300 9.28900   15.15500 1.000 31.13307 ? 519 ILE A CB  1 
ATOM   3810 C  CG1 . ILE A 1 525 ? 29.13500 8.83800   14.84100 1.000 30.12950 ? 519 ILE A CG1 1 
ATOM   3811 C  CG2 . ILE A 1 525 ? 30.99800 8.79400   16.53800 1.000 28.10154 ? 519 ILE A CG2 1 
ATOM   3812 C  CD1 . ILE A 1 525 ? 28.96000 7.29400   14.87300 1.000 36.42933 ? 519 ILE A CD1 1 
ATOM   3813 N  N   . THR A 1 526 ? 32.18700 11.75000  16.70600 1.000 26.52101 ? 520 THR A N   1 
ATOM   3814 C  CA  . THR A 1 526 ? 33.46500 12.27700  17.15300 1.000 28.36588 ? 520 THR A CA  1 
ATOM   3815 C  C   . THR A 1 526 ? 33.86000 11.57400  18.43600 1.000 26.12733 ? 520 THR A C   1 
ATOM   3816 O  O   . THR A 1 526 ? 33.15100 11.66700  19.44400 1.000 31.17224 ? 520 THR A O   1 
ATOM   3817 C  CB  . THR A 1 526 ? 33.41400 13.80000  17.34600 1.000 33.62968 ? 520 THR A CB  1 
ATOM   3818 O  OG1 . THR A 1 526 ? 33.05400 14.41800  16.10200 1.000 32.63281 ? 520 THR A OG1 1 
ATOM   3819 C  CG2 . THR A 1 526 ? 34.77700 14.32300  17.78000 1.000 31.18252 ? 520 THR A CG2 1 
ATOM   3820 N  N   . ILE A 1 527 ? 34.99600 10.89600  18.39000 1.000 26.06132 ? 521 ILE A N   1 
ATOM   3821 C  CA  . ILE A 1 527 ? 35.60100 10.25200  19.54900 1.000 29.17395 ? 521 ILE A CA  1 
ATOM   3822 C  C   . ILE A 1 527 ? 36.65500 11.19700  20.09300 1.000 28.82852 ? 521 ILE A C   1 
ATOM   3823 O  O   . ILE A 1 527 ? 37.58300 11.57200  19.36700 1.000 29.76688 ? 521 ILE A O   1 
ATOM   3824 C  CB  . ILE A 1 527 ? 36.23700 8.90500   19.17600 1.000 27.12852 ? 521 ILE A CB  1 
ATOM   3825 C  CG1 . ILE A 1 527 ? 35.19500 7.95000   18.60100 1.000 26.57979 ? 521 ILE A CG1 1 
ATOM   3826 C  CG2 . ILE A 1 527 ? 36.95100 8.29600   20.37800 1.000 30.87584 ? 521 ILE A CG2 1 
ATOM   3827 C  CD1 . ILE A 1 527 ? 35.78600 6.95900   17.63600 1.000 25.54397 ? 521 ILE A CD1 1 
ATOM   3828 N  N   . ASP A 1 528 ? 36.52000 11.55400  21.36700 1.000 23.34472 ? 522 ASP A N   1 
ATOM   3829 C  CA  . ASP A 1 528 ? 37.43200 12.44300  22.07900 1.000 32.74532 ? 522 ASP A CA  1 
ATOM   3830 C  C   . ASP A 1 528 ? 37.94700 11.73300  23.33300 1.000 28.33621 ? 522 ASP A C   1 
ATOM   3831 O  O   . ASP A 1 528 ? 37.22400 11.61700  24.32800 1.000 27.69609 ? 522 ASP A O   1 
ATOM   3832 C  CB  . ASP A 1 528 ? 36.71000 13.74300  22.43000 1.000 27.21273 ? 522 ASP A CB  1 
ATOM   3833 C  CG  . ASP A 1 528 ? 37.61800 14.76800  23.07800 1.000 33.21464 ? 522 ASP A CG  1 
ATOM   3834 O  OD1 . ASP A 1 528 ? 38.64200 14.38500  23.70300 1.000 29.29954 ? 522 ASP A OD1 1 
ATOM   3835 O  OD2 . ASP A 1 528 ? 37.28500 15.97000  22.98200 1.000 32.41657 ? 522 ASP A OD2 1 
ATOM   3836 N  N   . ILE A 1 529 ? 39.21600 11.31000  23.29900 1.000 29.56450 ? 523 ILE A N   1 
ATOM   3837 C  CA  . ILE A 1 529 ? 39.76900 10.50000  24.38100 1.000 31.01949 ? 523 ILE A CA  1 
ATOM   3838 C  C   . ILE A 1 529 ? 39.95400 11.33600  25.63400 1.000 33.81934 ? 523 ILE A C   1 
ATOM   3839 O  O   . ILE A 1 529 ? 39.70800 10.86100  26.75000 1.000 33.84902 ? 523 ILE A O   1 
ATOM   3840 C  CB  . ILE A 1 529 ? 41.09200 9.84200   23.94400 1.000 33.10915 ? 523 ILE A CB  1 
ATOM   3841 C  CG1 . ILE A 1 529 ? 40.87400 8.96100   22.71700 1.000 34.99171 ? 523 ILE A CG1 1 
ATOM   3842 C  CG2 . ILE A 1 529 ? 41.66400 9.00200   25.06900 1.000 35.06312 ? 523 ILE A CG2 1 
ATOM   3843 C  CD1 . ILE A 1 529 ? 39.83100 7.87200   22.90100 1.000 30.87572 ? 523 ILE A CD1 1 
ATOM   3844 N  N   . GLY A 1 530 ? 40.37400 12.59600  25.47300 1.000 36.12537 ? 524 GLY A N   1 
ATOM   3845 C  CA  . GLY A 1 530 ? 40.57700 13.45600  26.62900 1.000 29.53066 ? 524 GLY A CA  1 
ATOM   3846 C  C   . GLY A 1 530 ? 39.28500 13.78000  27.34800 1.000 31.44149 ? 524 GLY A C   1 
ATOM   3847 O  O   . GLY A 1 530 ? 39.22900 13.76400  28.58100 1.000 37.52260 ? 524 GLY A O   1 
ATOM   3848 N  N   . ALA A 1 531 ? 38.22800 14.08500  26.59500 1.000 29.29451 ? 525 ALA A N   1 
ATOM   3849 C  CA  . ALA A 1 531 ? 36.91400 14.24200  27.20600 1.000 29.98638 ? 525 ALA A CA  1 
ATOM   3850 C  C   . ALA A 1 531 ? 36.25700 12.90400  27.53200 1.000 27.79869 ? 525 ALA A C   1 
ATOM   3851 O  O   . ALA A 1 531 ? 35.27100 12.88500  28.28000 1.000 27.65441 ? 525 ALA A O   1 
ATOM   3852 C  CB  . ALA A 1 531 ? 35.98700 15.05300  26.29800 1.000 29.46830 ? 525 ALA A CB  1 
ATOM   3853 N  N   . ALA A 1 532 ? 36.78700 11.80000  27.00600 1.000 29.54084 ? 526 ALA A N   1 
ATOM   3854 C  CA  . ALA A 1 532 ? 36.23700 10.45900  27.22500 1.000 30.34909 ? 526 ALA A CA  1 
ATOM   3855 C  C   . ALA A 1 532 ? 34.77800 10.39200  26.77000 1.000 26.65334 ? 526 ALA A C   1 
ATOM   3856 O  O   . ALA A 1 532 ? 33.87200 10.03900  27.53000 1.000 30.05758 ? 526 ALA A O   1 
ATOM   3857 C  CB  . ALA A 1 532 ? 36.38900 10.03700  28.69000 1.000 32.70929 ? 526 ALA A CB  1 
ATOM   3858 N  N   . ARG A 1 533 ? 34.56700 10.72700  25.49200 1.000 25.77354 ? 527 ARG A N   1 
ATOM   3859 C  CA  . ARG A 1 533 ? 33.22900 10.85900  24.93400 1.000 26.87577 ? 527 ARG A CA  1 
ATOM   3860 C  C   . ARG A 1 533 ? 33.17800 10.34800  23.50100 1.000 27.52662 ? 527 ARG A C   1 
ATOM   3861 O  O   . ARG A 1 533 ? 34.08700 10.60200  22.70400 1.000 26.69728 ? 527 ARG A O   1 
ATOM   3862 C  CB  . ARG A 1 533 ? 32.76500 12.32500  24.96500 1.000 31.64241 ? 527 ARG A CB  1 
ATOM   3863 C  CG  . ARG A 1 533 ? 32.42700 12.84600  26.35800 1.000 30.08342 ? 527 ARG A CG  1 
ATOM   3864 C  CD  . ARG A 1 533 ? 31.94600 14.30200  26.29500 1.000 32.21289 ? 527 ARG A CD  1 
ATOM   3865 N  NE  . ARG A 1 533 ? 30.66200 14.40500  25.61000 1.000 30.00562 ? 527 ARG A NE  1 
ATOM   3866 C  CZ  . ARG A 1 533 ? 29.48900 14.45500  26.22200 1.000 32.65590 ? 527 ARG A CZ  1 
ATOM   3867 N  NH1 . ARG A 1 533 ? 29.40000 14.49100  27.54000 1.000 31.60572 ? 527 ARG A NH1 1 
ATOM   3868 N  NH2 . ARG A 1 533 ? 28.37700 14.46200  25.49300 1.000 31.42290 ? 527 ARG A NH2 1 
ATOM   3869 N  N   . ILE A 1 534 ? 32.10600 9.63300   23.18200 1.000 28.00177 ? 528 ILE A N   1 
ATOM   3870 C  CA  . ILE A 1 534 ? 31.75100 9.28400   21.81400 1.000 28.29225 ? 528 ILE A CA  1 
ATOM   3871 C  C   . ILE A 1 534 ? 30.47100 10.04400  21.50100 1.000 30.55303 ? 528 ILE A C   1 
ATOM   3872 O  O   . ILE A 1 534 ? 29.38700 9.68200   21.97700 1.000 29.22044 ? 528 ILE A O   1 
ATOM   3873 C  CB  . ILE A 1 534 ? 31.56700 7.77400   21.63000 1.000 26.75285 ? 528 ILE A CB  1 
ATOM   3874 C  CG1 . ILE A 1 534 ? 32.76700 7.00400   22.20800 1.000 24.54739 ? 528 ILE A CG1 1 
ATOM   3875 C  CG2 . ILE A 1 534 ? 31.36100 7.44200   20.16700 1.000 23.61264 ? 528 ILE A CG2 1 
ATOM   3876 C  CD1 . ILE A 1 534 ? 32.53000 5.48500   22.30300 1.000 26.67947 ? 528 ILE A CD1 1 
ATOM   3877 N  N   . ASP A 1 535 ? 30.59100 11.10300  20.70500 1.000 30.74109 ? 529 ASP A N   1 
ATOM   3878 C  CA  . ASP A 1 535 ? 29.51100 12.05200  20.50200 1.000 30.41723 ? 529 ASP A CA  1 
ATOM   3879 C  C   . ASP A 1 535 ? 29.00400 11.99500  19.06900 1.000 30.66647 ? 529 ASP A C   1 
ATOM   3880 O  O   . ASP A 1 535 ? 29.69900 11.54400  18.15300 1.000 28.71144 ? 529 ASP A O   1 
ATOM   3881 C  CB  . ASP A 1 535 ? 29.97700 13.47500  20.83100 1.000 30.98317 ? 529 ASP A CB  1 
ATOM   3882 C  CG  . ASP A 1 535 ? 30.13000 13.71000  22.31900 1.000 33.54650 ? 529 ASP A CG  1 
ATOM   3883 O  OD1 . ASP A 1 535 ? 29.33100 13.14800  23.09500 1.000 34.58668 ? 529 ASP A OD1 1 
ATOM   3884 O  OD2 . ASP A 1 535 ? 31.04800 14.46400  22.71200 1.000 35.24726 ? 529 ASP A OD2 1 
ATOM   3885 N  N   . THR A 1 536 ? 27.77500 12.47700  18.88400 1.000 30.94038 ? 530 THR A N   1 
ATOM   3886 C  CA  . THR A 1 536 ? 27.18200 12.61600  17.56100 1.000 34.76753 ? 530 THR A CA  1 
ATOM   3887 C  C   . THR A 1 536 ? 26.88000 14.08300  17.28400 1.000 36.54345 ? 530 THR A C   1 
ATOM   3888 O  O   . THR A 1 536 ? 26.47900 14.82300  18.18900 1.000 31.93747 ? 530 THR A O   1 
ATOM   3889 C  CB  . THR A 1 536 ? 25.88900 11.78200  17.41300 1.000 31.07390 ? 530 THR A CB  1 
ATOM   3890 O  OG1 . THR A 1 536 ? 25.35600 11.95700  16.09400 1.000 31.43945 ? 530 THR A OG1 1 
ATOM   3891 C  CG2 . THR A 1 536 ? 24.83600 12.17700  18.43800 1.000 29.89622 ? 530 THR A CG2 1 
ATOM   3892 N  N   . GLN A 1 537 ? 27.10400 14.49600  16.02800 1.000 33.47364 ? 531 GLN A N   1 
ATOM   3893 C  CA  . GLN A 1 537 ? 26.67700 15.81700  15.57100 1.000 37.34566 ? 531 GLN A CA  1 
ATOM   3894 C  C   . GLN A 1 537 ? 25.16000 15.95500  15.51600 1.000 43.09891 ? 531 GLN A C   1 
ATOM   3895 O  O   . GLN A 1 537 ? 24.65100 17.08400  15.55500 1.000 37.13581 ? 531 GLN A O   1 
ATOM   3896 C  CB  . GLN A 1 537 ? 27.25400 16.11200  14.18800 1.000 36.92534 ? 531 GLN A CB  1 
ATOM   3897 C  CG  . GLN A 1 537 ? 27.81900 17.51100  14.02500 1.000 44.33874 ? 531 GLN A CG  1 
ATOM   3898 C  CD  . GLN A 1 537 ? 28.56900 17.68300  12.70900 1.000 40.52956 ? 531 GLN A CD  1 
ATOM   3899 O  OE1 . GLN A 1 537 ? 29.79100 17.55600  12.65700 1.000 36.39441 ? 531 GLN A OE1 1 
ATOM   3900 N  NE2 . GLN A 1 537 ? 27.83300 17.97100  11.64100 1.000 43.01972 ? 531 GLN A NE2 1 
ATOM   3901 N  N   . VAL A 1 538 ? 24.43400 14.83800  15.39600 1.000 33.95737 ? 532 VAL A N   1 
ATOM   3902 C  CA  . VAL A 1 538 ? 22.97900 14.88100  15.43100 1.000 32.97760 ? 532 VAL A CA  1 
ATOM   3903 C  C   . VAL A 1 538 ? 22.53100 15.51700  16.74100 1.000 36.64938 ? 532 VAL A C   1 
ATOM   3904 O  O   . VAL A 1 538 ? 23.12400 15.27900  17.80100 1.000 38.41560 ? 532 VAL A O   1 
ATOM   3905 C  CB  . VAL A 1 538 ? 22.41600 13.45700  15.26500 1.000 33.81488 ? 532 VAL A CB  1 
ATOM   3906 C  CG1 . VAL A 1 538 ? 20.89300 13.45600  15.33800 1.000 36.19249 ? 532 VAL A CG1 1 
ATOM   3907 C  CG2 . VAL A 1 538 ? 22.88800 12.85300  13.96600 1.000 29.18176 ? 532 VAL A CG2 1 
ATOM   3908 N  N   . SER A 1 539 ? 21.49600 16.35400  16.67200 1.000 36.93311 ? 533 SER A N   1 
ATOM   3909 C  CA  . SER A 1 539 ? 21.03400 17.04600  17.86600 1.000 35.48789 ? 533 SER A CA  1 
ATOM   3910 C  C   . SER A 1 539 ? 20.38200 16.06200  18.83800 1.000 40.74242 ? 533 SER A C   1 
ATOM   3911 O  O   . SER A 1 539 ? 19.84300 15.03500  18.42300 1.000 36.06845 ? 533 SER A O   1 
ATOM   3912 C  CB  . SER A 1 539 ? 20.02900 18.13600  17.50400 1.000 44.07479 ? 533 SER A CB  1 
ATOM   3913 O  OG  . SER A 1 539 ? 18.76900 17.58400  17.16900 1.000 46.55185 ? 533 SER A OG  1 
ATOM   3914 N  N   . PRO A 1 540 ? 20.41000 16.36100  20.14000 1.000 42.77115 ? 534 PRO A N   1 
ATOM   3915 C  CA  . PRO A 1 540 ? 19.68100 15.51200  21.09400 1.000 46.27205 ? 534 PRO A CA  1 
ATOM   3916 C  C   . PRO A 1 540 ? 18.19700 15.43600  20.79700 1.000 50.15843 ? 534 PRO A C   1 
ATOM   3917 O  O   . PRO A 1 540 ? 17.56700 14.40900  21.07600 1.000 47.04658 ? 534 PRO A O   1 
ATOM   3918 C  CB  . PRO A 1 540 ? 19.96100 16.19900  22.43900 1.000 45.80633 ? 534 PRO A CB  1 
ATOM   3919 C  CG  . PRO A 1 540 ? 21.30100 16.84900  22.23200 1.000 41.84602 ? 534 PRO A CG  1 
ATOM   3920 C  CD  . PRO A 1 540 ? 21.18800 17.40100  20.83200 1.000 38.01110 ? 534 PRO A CD  1 
ATOM   3921 N  N   . GLU A 1 541 ? 17.62500 16.48700  20.20400 1.000 50.32670 ? 535 GLU A N   1 
ATOM   3922 C  CA  . GLU A 1 541 ? 16.20400 16.47300  19.87700 1.000 47.78866 ? 535 GLU A CA  1 
ATOM   3923 C  C   . GLU A 1 541 ? 15.91600 15.55100  18.69900 1.000 49.08833 ? 535 GLU A C   1 
ATOM   3924 O  O   . GLU A 1 541 ? 14.91700 14.82100  18.71200 1.000 50.34669 ? 535 GLU A O   1 
ATOM   3925 C  CB  . GLU A 1 541 ? 15.71800 17.89600  19.58500 1.000 49.15435 ? 535 GLU A CB  1 
ATOM   3926 C  CG  . GLU A 1 541 ? 15.72300 18.81800  20.80800 1.000 52.16333 ? 535 GLU A CG  1 
ATOM   3927 C  CD  . GLU A 1 541 ? 17.11900 19.35300  21.14000 1.000 60.10246 ? 535 GLU A CD  1 
ATOM   3928 O  OE1 . GLU A 1 541 ? 17.98600 19.38100  20.23200 1.000 55.72551 ? 535 GLU A OE1 1 
ATOM   3929 O  OE2 . GLU A 1 541 ? 17.35500 19.73600  22.31100 1.000 63.72800 ? 535 GLU A OE2 1 
ATOM   3930 N  N   . GLU A 1 542 ? 16.76600 15.57000  17.66600 1.000 42.33240 ? 536 GLU A N   1 
ATOM   3931 C  CA  . GLU A 1 542 ? 16.55800 14.65000  16.54900 1.000 43.63003 ? 536 GLU A CA  1 
ATOM   3932 C  C   . GLU A 1 542 ? 16.82000 13.20700  16.97000 1.000 46.17054 ? 536 GLU A C   1 
ATOM   3933 O  O   . GLU A 1 542 ? 16.15100 12.28300  16.49000 1.000 44.55317 ? 536 GLU A O   1 
ATOM   3934 C  CB  . GLU A 1 542 ? 17.44700 15.01200  15.36200 1.000 38.10686 ? 536 GLU A CB  1 
ATOM   3935 C  CG  . GLU A 1 542 ? 17.43800 13.94200  14.26200 1.000 43.17300 ? 536 GLU A CG  1 
ATOM   3936 C  CD  . GLU A 1 542 ? 18.11700 14.39900  12.98300 1.000 53.52785 ? 536 GLU A CD  1 
ATOM   3937 O  OE1 . GLU A 1 542 ? 18.44900 15.60400  12.89900 1.000 58.93694 ? 536 GLU A OE1 1 
ATOM   3938 O  OE2 . GLU A 1 542 ? 18.33900 13.55600  12.07200 1.000 46.68986 ? 536 GLU A OE2 1 
ATOM   3939 N  N   . MET A 1 543 ? 17.80400 12.99100  17.84500 1.000 41.87509 ? 537 MET A N   1 
ATOM   3940 C  CA  . MET A 1 543 ? 18.02700 11.65500  18.38300 1.000 48.69523 ? 537 MET A CA  1 
ATOM   3941 C  C   . MET A 1 543 ? 16.77800 11.15400  19.10700 1.000 49.43467 ? 537 MET A C   1 
ATOM   3942 O  O   . MET A 1 543 ? 16.33800 10.01900  18.89000 1.000 43.93325 ? 537 MET A O   1 
ATOM   3943 C  CB  . MET A 1 543 ? 19.24000 11.65900  19.31600 1.000 36.90562 ? 537 MET A CB  1 
ATOM   3944 C  CG  . MET A 1 543 ? 20.63200 11.61600  18.64100 1.000 31.64249 ? 537 MET A CG  1 
ATOM   3945 S  SD  . MET A 1 543 ? 20.87000 10.38400  17.36500 1.000 33.27524 ? 537 MET A SD  1 
ATOM   3946 C  CE  . MET A 1 543 ? 21.76100 9.11100   18.25300 1.000 35.32757 ? 537 MET A CE  1 
ATOM   3947 N  N   . ASN A 1 544 ? 16.18300 12.00500  19.95600 1.000 47.76869 ? 538 ASN A N   1 
ATOM   3948 C  CA  . ASN A 1 544 ? 14.95300 11.63900  20.65700 1.000 50.72233 ? 538 ASN A CA  1 
ATOM   3949 C  C   . ASN A 1 544 ? 13.81400 11.35600  19.68500 1.000 52.17397 ? 538 ASN A C   1 
ATOM   3950 O  O   . ASN A 1 544 ? 12.97100 10.48800  19.94000 1.000 52.57164 ? 538 ASN A O   1 
ATOM   3951 C  CB  . ASN A 1 544 ? 14.54600 12.73900  21.63500 1.000 51.25537 ? 538 ASN A CB  1 
ATOM   3952 C  CG  . ASN A 1 544 ? 13.59500 12.23700  22.71600 1.000 59.46736 ? 538 ASN A CG  1 
ATOM   3953 O  OD1 . ASN A 1 544 ? 13.67600 11.08400  23.15200 1.000 61.13796 ? 538 ASN A OD1 1 
ATOM   3954 N  ND2 . ASN A 1 544 ? 12.66800 13.09400  23.12900 1.000 58.17362 ? 538 ASN A ND2 1 
ATOM   3955 N  N   . ASP A 1 545 ? 13.76000 12.09100  18.57400 1.000 49.52846 ? 539 ASP A N   1 
ATOM   3956 C  CA  . ASP A 1 545 ? 12.76900 11.79200  17.54800 1.000 50.62454 ? 539 ASP A CA  1 
ATOM   3957 C  C   . ASP A 1 545 ? 12.98000 10.39200  16.99700 1.000 48.06118 ? 539 ASP A C   1 
ATOM   3958 O  O   . ASP A 1 545 ? 12.02600 9.62000   16.84800 1.000 45.26872 ? 539 ASP A O   1 
ATOM   3959 C  CB  . ASP A 1 545 ? 12.84000 12.82100  16.41800 1.000 49.39692 ? 539 ASP A CB  1 
ATOM   3960 C  CG  . ASP A 1 545 ? 12.29500 14.17200  16.82500 1.000 57.00475 ? 539 ASP A CG  1 
ATOM   3961 O  OD1 . ASP A 1 545 ? 11.39700 14.21600  17.69500 1.000 58.34607 ? 539 ASP A OD1 1 
ATOM   3962 O  OD2 . ASP A 1 545 ? 12.78900 15.19200  16.29200 1.000 57.92543 ? 539 ASP A OD2 1 
ATOM   3963 N  N   . ARG A 1 546 ? 14.22800 10.05400  16.66400 1.000 44.09915 ? 540 ARG A N   1 
ATOM   3964 C  CA  . ARG A 1 546 ? 14.52300 8.70300   16.20000 1.000 46.43692 ? 540 ARG A CA  1 
ATOM   3965 C  C   . ARG A 1 546 ? 14.11800 7.66400   17.23700 1.000 40.47557 ? 540 ARG A C   1 
ATOM   3966 O  O   . ARG A 1 546 ? 13.59700 6.60000   16.88500 1.000 45.59314 ? 540 ARG A O   1 
ATOM   3967 C  CB  . ARG A 1 546 ? 16.01000 8.57100   15.87200 1.000 40.76018 ? 540 ARG A CB  1 
ATOM   3968 C  CG  . ARG A 1 546 ? 16.44600 9.29600   14.61000 1.000 43.29149 ? 540 ARG A CG  1 
ATOM   3969 C  CD  . ARG A 1 546 ? 17.95600 9.38300   14.54200 1.000 42.31144 ? 540 ARG A CD  1 
ATOM   3970 N  NE  . ARG A 1 546 ? 18.44500 10.19500  13.43300 1.000 35.50384 ? 540 ARG A NE  1 
ATOM   3971 C  CZ  . ARG A 1 546 ? 19.71100 10.21200  13.03300 1.000 42.08327 ? 540 ARG A CZ  1 
ATOM   3972 N  NH1 . ARG A 1 546 ? 20.62100 9.42300   13.58200 1.000 33.70543 ? 540 ARG A NH1 1 
ATOM   3973 N  NH2 . ARG A 1 546 ? 20.07600 11.04100  12.06100 1.000 42.10947 ? 540 ARG A NH2 1 
ATOM   3974 N  N   . ARG A 1 547 ? 14.35400 7.95800   18.52000 1.000 42.40063 ? 541 ARG A N   1 
ATOM   3975 C  CA  . ARG A 1 547 ? 14.03400 7.01600   19.59100 1.000 47.12508 ? 541 ARG A CA  1 
ATOM   3976 C  C   . ARG A 1 547 ? 12.53400 6.76700   19.68300 1.000 49.38006 ? 541 ARG A C   1 
ATOM   3977 O  O   . ARG A 1 547 ? 12.09500 5.62300   19.85800 1.000 45.66471 ? 541 ARG A O   1 
ATOM   3978 C  CB  . ARG A 1 547 ? 14.57000 7.54500   20.92300 1.000 45.52014 ? 541 ARG A CB  1 
ATOM   3979 C  CG  . ARG A 1 547 ? 14.42300 6.59100   22.12300 1.000 52.14756 ? 541 ARG A CG  1 
ATOM   3980 C  CD  . ARG A 1 547 ? 14.74200 5.12600   21.75900 1.000 53.10663 ? 541 ARG A CD  1 
ATOM   3981 N  NE  . ARG A 1 547 ? 14.56900 4.22800   22.90100 1.000 55.45599 ? 541 ARG A NE  1 
ATOM   3982 C  CZ  . ARG A 1 547 ? 13.49900 3.46600   23.10000 1.000 57.83524 ? 541 ARG A CZ  1 
ATOM   3983 N  NH1 . ARG A 1 547 ? 12.48100 3.46400   22.24700 1.000 54.09653 ? 541 ARG A NH1 1 
ATOM   3984 N  NH2 . ARG A 1 547 ? 13.44000 2.69700   24.18800 1.000 54.34545 ? 541 ARG A NH2 1 
ATOM   3985 N  N   . LYS A 1 548 ? 11.72900 7.82900   19.56800 1.000 47.11437 ? 542 LYS A N   1 
ATOM   3986 C  CA  . LYS A 1 548 ? 10.27800 7.67900   19.64000 1.000 47.03834 ? 542 LYS A CA  1 
ATOM   3987 C  C   . LYS A 1 548 ? 9.75000  6.79200   18.52400 1.000 43.15152 ? 542 LYS A C   1 
ATOM   3988 O  O   . LYS A 1 548 ? 8.71900  6.13100   18.69000 1.000 51.96697 ? 542 LYS A O   1 
ATOM   3989 C  CB  . LYS A 1 548 ? 9.60400  9.05000   19.57500 1.000 45.37920 ? 542 LYS A CB  1 
ATOM   3990 C  CG  . LYS A 1 548 ? 9.87700  9.92900   20.78800 1.000 50.98751 ? 542 LYS A CG  1 
ATOM   3991 C  CD  . LYS A 1 548 ? 8.96600  11.15000  20.79500 1.000 55.93190 ? 542 LYS A CD  1 
ATOM   3992 C  CE  . LYS A 1 548 ? 9.68500  12.41500  20.35800 1.000 60.32486 ? 542 LYS A CE  1 
ATOM   3993 N  NZ  . LYS A 1 548 ? 9.19200  13.60900  21.12900 1.000 63.35143 ? 542 LYS A NZ  1 
ATOM   3994 N  N   . LYS A 1 549 ? 10.43100 6.77400   17.38400 1.000 39.11424 ? 543 LYS A N   1 
ATOM   3995 C  CA  . LYS A 1 549 ? 10.05500 5.93700   16.25800 1.000 38.51103 ? 543 LYS A CA  1 
ATOM   3996 C  C   . LYS A 1 549 ? 10.68200 4.54700   16.30500 1.000 41.91068 ? 543 LYS A C   1 
ATOM   3997 O  O   . LYS A 1 549 ? 10.31500 3.69600   15.49500 1.000 40.93677 ? 543 LYS A O   1 
ATOM   3998 C  CB  . LYS A 1 549 ? 10.45300 6.62400   14.94800 1.000 40.88790 ? 543 LYS A CB  1 
ATOM   3999 C  CG  . LYS A 1 549 ? 9.49200  7.73800   14.52500 1.000 51.69702 ? 543 LYS A CG  1 
ATOM   4000 C  CD  . LYS A 1 549 ? 10.21900 9.05600   14.28600 1.000 56.75932 ? 543 LYS A CD  1 
ATOM   4001 C  CE  . LYS A 1 549 ? 9.26200  10.25800  14.36000 1.000 55.14612 ? 543 LYS A CE  1 
ATOM   4002 N  NZ  . LYS A 1 549 ? 9.79900  11.35300  15.23000 1.000 56.47942 ? 543 LYS A NZ  1 
ATOM   4003 N  N   . TRP A 1 550 ? 11.61500 4.29500   17.21500 1.000 41.11572 ? 544 TRP A N   1 
ATOM   4004 C  CA  . TRP A 1 550 ? 12.38200 3.05300   17.18100 1.000 43.39849 ? 544 TRP A CA  1 
ATOM   4005 C  C   . TRP A 1 550 ? 11.60200 1.91600   17.82500 1.000 39.36768 ? 544 TRP A C   1 
ATOM   4006 O  O   . TRP A 1 550 ? 10.98000 2.09100   18.87800 1.000 38.77103 ? 544 TRP A O   1 
ATOM   4007 C  CB  . TRP A 1 550 ? 13.72000 3.23400   17.90200 1.000 42.29279 ? 544 TRP A CB  1 
ATOM   4008 C  CG  . TRP A 1 550 ? 14.50200 1.94700   18.17500 1.000 42.23904 ? 544 TRP A CG  1 
ATOM   4009 C  CD1 . TRP A 1 550 ? 15.44700 1.37700   17.37400 1.000 41.44983 ? 544 TRP A CD1 1 
ATOM   4010 C  CD2 . TRP A 1 550 ? 14.42000 1.11900   19.34400 1.000 39.39187 ? 544 TRP A CD2 1 
ATOM   4011 N  NE1 . TRP A 1 550 ? 15.94900 0.24300   17.96100 1.000 39.48378 ? 544 TRP A NE1 1 
ATOM   4012 C  CE2 . TRP A 1 550 ? 15.33700 0.06000   19.17100 1.000 35.84692 ? 544 TRP A CE2 1 
ATOM   4013 C  CE3 . TRP A 1 550 ? 13.65800 1.16900   20.52000 1.000 38.00528 ? 544 TRP A CE3 1 
ATOM   4014 C  CZ2 . TRP A 1 550 ? 15.50800 -0.94800  20.12500 1.000 33.42588 ? 544 TRP A CZ2 1 
ATOM   4015 C  CZ3 . TRP A 1 550 ? 13.83800 0.17400   21.47600 1.000 43.12534 ? 544 TRP A CZ3 1 
ATOM   4016 C  CH2 . TRP A 1 550 ? 14.75500 -0.87400  21.26800 1.000 37.38898 ? 544 TRP A CH2 1 
ATOM   4017 N  N   . THR A 1 551 ? 11.65300 0.74300   17.19400 1.000 43.64932 ? 545 THR A N   1 
ATOM   4018 C  CA  . THR A 1 551 ? 11.06100 -0.46800  17.74400 1.000 46.03315 ? 545 THR A CA  1 
ATOM   4019 C  C   . THR A 1 551 ? 12.13200 -1.55100  17.88000 1.000 42.06425 ? 545 THR A C   1 
ATOM   4020 O  O   . THR A 1 551 ? 12.93500 -1.76600  16.96200 1.000 37.92311 ? 545 THR A O   1 
ATOM   4021 C  CB  . THR A 1 551 ? 9.88100  -0.93800  16.87900 1.000 41.58668 ? 545 THR A CB  1 
ATOM   4022 O  OG1 . THR A 1 551 ? 9.24300  -2.05600  17.50800 1.000 55.78264 ? 545 THR A OG1 1 
ATOM   4023 C  CG2 . THR A 1 551 ? 10.33500 -1.33300  15.48700 1.000 49.68904 ? 545 THR A CG2 1 
ATOM   4024 N  N   . ALA A 1 552 ? 12.16100 -2.20600  19.03900 1.000 40.57130 ? 546 ALA A N   1 
ATOM   4025 C  CA  . ALA A 1 552 ? 13.16900 -3.23100  19.30000 1.000 37.60287 ? 546 ALA A CA  1 
ATOM   4026 C  C   . ALA A 1 552 ? 13.05100 -4.36000  18.28200 1.000 35.74598 ? 546 ALA A C   1 
ATOM   4027 O  O   . ALA A 1 552 ? 11.93700 -4.81700  18.00300 1.000 40.27017 ? 546 ALA A O   1 
ATOM   4028 C  CB  . ALA A 1 552 ? 13.01500 -3.78500  20.71700 1.000 34.95861 ? 546 ALA A CB  1 
ATOM   4029 N  N   . PRO A 1 553 ? 14.15900 -4.82900  17.70400 1.000 36.80741 ? 547 PRO A N   1 
ATOM   4030 C  CA  . PRO A 1 553 ? 14.08700 -5.98900  16.80900 1.000 35.19455 ? 547 PRO A CA  1 
ATOM   4031 C  C   . PRO A 1 553 ? 13.67000 -7.23600  17.57700 1.000 33.01438 ? 547 PRO A C   1 
ATOM   4032 O  O   . PRO A 1 553 ? 13.84000 -7.33300  18.79400 1.000 32.32264 ? 547 PRO A O   1 
ATOM   4033 C  CB  . PRO A 1 553 ? 15.51700 -6.12900  16.27600 1.000 34.01822 ? 547 PRO A CB  1 
ATOM   4034 C  CG  . PRO A 1 553 ? 16.18500 -4.82500  16.61000 1.000 36.20630 ? 547 PRO A CG  1 
ATOM   4035 C  CD  . PRO A 1 553 ? 15.53600 -4.34000  17.85600 1.000 33.51873 ? 547 PRO A CD  1 
ATOM   4036 N  N   . ALA A 1 554 ? 13.10100 -8.19200  16.84300 1.000 30.52464 ? 548 ALA A N   1 
ATOM   4037 C  CA  . ALA A 1 554 ? 12.80300 -9.50500  17.40400 1.000 35.83421 ? 548 ALA A CA  1 
ATOM   4038 C  C   . ALA A 1 554 ? 14.08300 -10.19100 17.86200 1.000 29.05029 ? 548 ALA A C   1 
ATOM   4039 O  O   . ALA A 1 554 ? 15.13000 -10.07800 17.21800 1.000 29.89150 ? 548 ALA A O   1 
ATOM   4040 C  CB  . ALA A 1 554 ? 12.10300 -10.38600 16.36300 1.000 31.75644 ? 548 ALA A CB  1 
ATOM   4041 N  N   . TYR A 1 555 ? 13.99300 -10.90800 18.98200 1.000 33.36991 ? 549 TYR A N   1 
ATOM   4042 C  CA  . TYR A 1 555 ? 15.12100 -11.71600 19.42800 1.000 27.93300 ? 549 TYR A CA  1 
ATOM   4043 C  C   . TYR A 1 555 ? 15.44500 -12.75500 18.37100 1.000 27.08284 ? 549 TYR A C   1 
ATOM   4044 O  O   . TYR A 1 555 ? 14.55100 -13.30500 17.72400 1.000 29.10257 ? 549 TYR A O   1 
ATOM   4045 C  CB  . TYR A 1 555 ? 14.80700 -12.38500 20.77100 1.000 24.29125 ? 549 TYR A CB  1 
ATOM   4046 C  CG  . TYR A 1 555 ? 14.70900 -11.40500 21.92400 1.000 22.96211 ? 549 TYR A CG  1 
ATOM   4047 C  CD1 . TYR A 1 555 ? 15.67500 -10.41500 22.10900 1.000 26.07751 ? 549 TYR A CD1 1 
ATOM   4048 C  CD2 . TYR A 1 555 ? 13.64900 -11.46000 22.81400 1.000 30.27025 ? 549 TYR A CD2 1 
ATOM   4049 C  CE1 . TYR A 1 555 ? 15.57800 -9.50900  23.15800 1.000 26.24041 ? 549 TYR A CE1 1 
ATOM   4050 C  CE2 . TYR A 1 555 ? 13.54500 -10.56900 23.87000 1.000 29.64642 ? 549 TYR A CE2 1 
ATOM   4051 C  CZ  . TYR A 1 555 ? 14.51000 -9.59600  24.03500 1.000 29.48674 ? 549 TYR A CZ  1 
ATOM   4052 O  OH  . TYR A 1 555 ? 14.39300 -8.71200  25.08400 1.000 36.00406 ? 549 TYR A OH  1 
ATOM   4053 N  N   . LYS A 1 556 ? 16.73600 -13.02600 18.19900 1.000 26.33133 ? 550 LYS A N   1 
ATOM   4054 C  CA  . LYS A 1 556 ? 17.17800 -13.96700 17.18100 1.000 30.91779 ? 550 LYS A CA  1 
ATOM   4055 C  C   . LYS A 1 556 ? 16.91500 -15.42500 17.55400 1.000 32.43611 ? 550 LYS A C   1 
ATOM   4056 O  O   . LYS A 1 556 ? 16.95500 -16.29000 16.67400 1.000 28.38026 ? 550 LYS A O   1 
ATOM   4057 C  CB  . LYS A 1 556 ? 18.66800 -13.76500 16.91200 1.000 30.47852 ? 550 LYS A CB  1 
ATOM   4058 C  CG  . LYS A 1 556 ? 19.02200 -12.35900 16.40800 1.000 33.75798 ? 550 LYS A CG  1 
ATOM   4059 C  CD  . LYS A 1 556 ? 20.43400 -12.32300 15.85800 1.000 33.13674 ? 550 LYS A CD  1 
ATOM   4060 C  CE  . LYS A 1 556 ? 20.88500 -10.91000 15.56700 1.000 38.68319 ? 550 LYS A CE  1 
ATOM   4061 N  NZ  . LYS A 1 556 ? 22.37800 -10.84900 15.60700 1.000 42.89030 ? 550 LYS A NZ  1 
ATOM   4062 N  N   . VAL A 1 557 ? 16.67000 -15.73100 18.82900 1.000 24.70847 ? 551 VAL A N   1 
ATOM   4063 C  CA  . VAL A 1 557 ? 16.37100 -17.09800 19.23800 1.000 23.32019 ? 551 VAL A CA  1 
ATOM   4064 C  C   . VAL A 1 557 ? 15.12400 -17.05500 20.10200 1.000 24.94841 ? 551 VAL A C   1 
ATOM   4065 O  O   . VAL A 1 557 ? 14.75900 -16.01600 20.65400 1.000 25.76311 ? 551 VAL A O   1 
ATOM   4066 C  CB  . VAL A 1 557 ? 17.52900 -17.77900 19.99800 1.000 25.72024 ? 551 VAL A CB  1 
ATOM   4067 C  CG1 . VAL A 1 557 ? 18.70600 -18.01900 19.06100 1.000 25.02466 ? 551 VAL A CG1 1 
ATOM   4068 C  CG2 . VAL A 1 557 ? 17.95700 -16.94900 21.22700 1.000 23.47666 ? 551 VAL A CG2 1 
ATOM   4069 N  N   . ASN A 1 558 ? 14.45100 -18.19500 20.19400 1.000 25.49674 ? 552 ASN A N   1 
ATOM   4070 C  CA  . ASN A 1 558 ? 13.26800 -18.28200 21.03000 1.000 29.26684 ? 552 ASN A CA  1 
ATOM   4071 C  C   . ASN A 1 558 ? 13.31300 -19.46200 21.98500 1.000 29.41517 ? 552 ASN A C   1 
ATOM   4072 O  O   . ASN A 1 558 ? 12.35400 -19.65700 22.74000 1.000 25.00974 ? 552 ASN A O   1 
ATOM   4073 C  CB  . ASN A 1 558 ? 11.99500 -18.34800 20.16100 1.000 28.31617 ? 552 ASN A CB  1 
ATOM   4074 C  CG  . ASN A 1 558 ? 11.87200 -19.65000 19.37100 1.000 30.08151 ? 552 ASN A CG  1 
ATOM   4075 O  OD1 . ASN A 1 558 ? 12.81200 -20.43300 19.26200 1.000 30.22968 ? 552 ASN A OD1 1 
ATOM   4076 N  ND2 . ASN A 1 558 ? 10.70000 -19.86800 18.79000 1.000 39.09236 ? 552 ASN A ND2 1 
ATOM   4077 N  N   . ARG A 1 559 ? 14.40600 -20.23300 21.99500 1.000 22.09359 ? 553 ARG A N   1 
ATOM   4078 C  CA  . ARG A 1 559 ? 14.53400 -21.40600 22.85200 1.000 22.37369 ? 553 ARG A CA  1 
ATOM   4079 C  C   . ARG A 1 559 ? 16.00100 -21.59000 23.22400 1.000 25.41217 ? 553 ARG A C   1 
ATOM   4080 O  O   . ARG A 1 559 ? 16.89200 -20.97100 22.64000 1.000 22.94402 ? 553 ARG A O   1 
ATOM   4081 C  CB  . ARG A 1 559 ? 14.01500 -22.66400 22.14700 1.000 23.59573 ? 553 ARG A CB  1 
ATOM   4082 C  CG  . ARG A 1 559 ? 12.51400 -22.71900 21.95500 1.000 22.16115 ? 553 ARG A CG  1 
ATOM   4083 C  CD  . ARG A 1 559 ? 11.83900 -22.98600 23.26700 1.000 24.10357 ? 553 ARG A CD  1 
ATOM   4084 N  NE  . ARG A 1 559 ? 10.40000 -22.78700 23.18100 1.000 29.05255 ? 553 ARG A NE  1 
ATOM   4085 C  CZ  . ARG A 1 559 ? 9.53500  -23.72800 22.83000 1.000 36.83529 ? 553 ARG A CZ  1 
ATOM   4086 N  NH1 . ARG A 1 559 ? 9.92800  -24.96300 22.54900 1.000 36.23117 ? 553 ARG A NH1 1 
ATOM   4087 N  NH2 . ARG A 1 559 ? 8.24000  -23.42200 22.76000 1.000 41.73206 ? 553 ARG A NH2 1 
ATOM   4088 N  N   . GLY A 1 560 ? 16.24700 -22.46900 24.19200 1.000 21.40902 ? 554 GLY A N   1 
ATOM   4089 C  CA  . GLY A 1 560 ? 17.60000 -22.88800 24.49100 1.000 20.75680 ? 554 GLY A CA  1 
ATOM   4090 C  C   . GLY A 1 560 ? 18.36800 -21.95900 25.40900 1.000 18.48878 ? 554 GLY A C   1 
ATOM   4091 O  O   . GLY A 1 560 ? 17.86300 -20.95600 25.93500 1.000 19.90699 ? 554 GLY A O   1 
ATOM   4092 N  N   . VAL A 1 561 ? 19.64300 -22.31500 25.59100 1.000 19.88805 ? 555 VAL A N   1 
ATOM   4093 C  CA  . VAL A 1 561 ? 20.49200 -21.62600 26.56100 1.000 18.18063 ? 555 VAL A CA  1 
ATOM   4094 C  C   . VAL A 1 561 ? 20.61900 -20.14400 26.22900 1.000 19.17574 ? 555 VAL A C   1 
ATOM   4095 O  O   . VAL A 1 561 ? 20.69500 -19.30800 27.13200 1.000 17.94440 ? 555 VAL A O   1 
ATOM   4096 C  CB  . VAL A 1 561 ? 21.87900 -22.31300 26.64700 1.000 18.78685 ? 555 VAL A CB  1 
ATOM   4097 C  CG1 . VAL A 1 561 ? 22.64600 -22.19400 25.32000 1.000 15.40067 ? 555 VAL A CG1 1 
ATOM   4098 C  CG2 . VAL A 1 561 ? 22.70100 -21.72300 27.80900 1.000 19.02313 ? 555 VAL A CG2 1 
ATOM   4099 N  N   . LEU A 1 562 ? 20.62900 -19.78400 24.93900 1.000 16.62434 ? 556 LEU A N   1 
ATOM   4100 C  CA  . LEU A 1 562 ? 20.81200 -18.37900 24.59300 1.000 18.36284 ? 556 LEU A CA  1 
ATOM   4101 C  C   . LEU A 1 562 ? 19.52700 -17.57800 24.75200 1.000 22.58074 ? 556 LEU A C   1 
ATOM   4102 O  O   . LEU A 1 562 ? 19.58600 -16.36200 24.96600 1.000 21.57687 ? 556 LEU A O   1 
ATOM   4103 C  CB  . LEU A 1 562 ? 21.33200 -18.25500 23.15600 1.000 22.01793 ? 556 LEU A CB  1 
ATOM   4104 C  CG  . LEU A 1 562 ? 22.80600 -18.62000 22.95800 1.000 21.94189 ? 556 LEU A CG  1 
ATOM   4105 C  CD1 . LEU A 1 562 ? 23.24500 -18.22500 21.55100 1.000 24.68548 ? 556 LEU A CD1 1 
ATOM   4106 C  CD2 . LEU A 1 562 ? 23.67500 -17.93700 24.01100 1.000 22.29141 ? 556 LEU A CD2 1 
ATOM   4107 N  N   . TYR A 1 563 ? 18.35300 -18.21700 24.65300 1.000 20.66690 ? 557 TYR A N   1 
ATOM   4108 C  CA  . TYR A 1 563 ? 17.14800 -17.46300 24.98000 1.000 18.61581 ? 557 TYR A CA  1 
ATOM   4109 C  C   . TYR A 1 563 ? 17.09300 -17.17900 26.47200 1.000 20.87525 ? 557 TYR A C   1 
ATOM   4110 O  O   . TYR A 1 563 ? 16.69400 -16.08600 26.89500 1.000 18.63248 ? 557 TYR A O   1 
ATOM   4111 C  CB  . TYR A 1 563 ? 15.88100 -18.19500 24.51600 1.000 20.71416 ? 557 TYR A CB  1 
ATOM   4112 C  CG  . TYR A 1 563 ? 14.66900 -17.32500 24.73600 1.000 25.10067 ? 557 TYR A CG  1 
ATOM   4113 C  CD1 . TYR A 1 563 ? 14.58200 -16.06500 24.13200 1.000 25.15663 ? 557 TYR A CD1 1 
ATOM   4114 C  CD2 . TYR A 1 563 ? 13.65200 -17.71000 25.60600 1.000 25.29338 ? 557 TYR A CD2 1 
ATOM   4115 C  CE1 . TYR A 1 563 ? 13.48200 -15.23200 24.34700 1.000 26.80158 ? 557 TYR A CE1 1 
ATOM   4116 C  CE2 . TYR A 1 563 ? 12.54000 -16.88700 25.83200 1.000 25.54646 ? 557 TYR A CE2 1 
ATOM   4117 C  CZ  . TYR A 1 563 ? 12.46600 -15.64600 25.19200 1.000 32.07131 ? 557 TYR A CZ  1 
ATOM   4118 O  OH  . TYR A 1 563 ? 11.38900 -14.80900 25.41000 1.000 34.01343 ? 557 TYR A OH  1 
ATOM   4119 N  N   . LYS A 1 564 ? 17.52700 -18.13900 27.28800 1.000 17.19256 ? 558 LYS A N   1 
ATOM   4120 C  CA  . LYS A 1 564 ? 17.63600 -17.88700 28.71700 1.000 16.28985 ? 558 LYS A CA  1 
ATOM   4121 C  C   . LYS A 1 564 ? 18.63700 -16.77400 28.99800 1.000 20.46461 ? 558 LYS A C   1 
ATOM   4122 O  O   . LYS A 1 564 ? 18.40700 -15.92500 29.86600 1.000 20.30099 ? 558 LYS A O   1 
ATOM   4123 C  CB  . LYS A 1 564 ? 18.05300 -19.16000 29.45300 1.000 18.08501 ? 558 LYS A CB  1 
ATOM   4124 C  CG  . LYS A 1 564 ? 17.07900 -20.31600 29.29300 1.000 17.73584 ? 558 LYS A CG  1 
ATOM   4125 C  CD  . LYS A 1 564 ? 17.58900 -21.58400 29.99600 1.000 17.90567 ? 558 LYS A CD  1 
ATOM   4126 C  CE  . LYS A 1 564 ? 17.73700 -21.41000 31.50000 1.000 19.76944 ? 558 LYS A CE  1 
ATOM   4127 N  NZ  . LYS A 1 564 ? 18.12600 -22.73100 32.08800 1.000 19.07313 ? 558 LYS A NZ  1 
ATOM   4128 N  N   . TYR A 1 565 ? 19.77200 -16.77600 28.29100 1.000 17.90433 ? 559 TYR A N   1 
ATOM   4129 C  CA  . TYR A 1 565 ? 20.71500 -15.67400 28.46700 1.000 22.09030 ? 559 TYR A CA  1 
ATOM   4130 C  C   . TYR A 1 565 ? 20.04700 -14.32800 28.19100 1.000 19.06366 ? 559 TYR A C   1 
ATOM   4131 O  O   . TYR A 1 565 ? 20.20200 -13.37400 28.96100 1.000 21.69946 ? 559 TYR A O   1 
ATOM   4132 C  CB  . TYR A 1 565 ? 21.90200 -15.86200 27.54200 1.000 16.17756 ? 559 TYR A CB  1 
ATOM   4133 C  CG  . TYR A 1 565 ? 23.08600 -14.96100 27.84000 1.000 21.46089 ? 559 TYR A CG  1 
ATOM   4134 C  CD1 . TYR A 1 565 ? 23.83400 -15.12700 29.00200 1.000 17.79640 ? 559 TYR A CD1 1 
ATOM   4135 C  CD2 . TYR A 1 565 ? 23.48700 -13.97700 26.92900 1.000 23.23827 ? 559 TYR A CD2 1 
ATOM   4136 C  CE1 . TYR A 1 565 ? 24.94700 -14.34400 29.26300 1.000 19.53655 ? 559 TYR A CE1 1 
ATOM   4137 C  CE2 . TYR A 1 565 ? 24.60200 -13.17400 27.18300 1.000 20.93782 ? 559 TYR A CE2 1 
ATOM   4138 C  CZ  . TYR A 1 565 ? 25.32700 -13.36400 28.35100 1.000 19.98960 ? 559 TYR A CZ  1 
ATOM   4139 O  OH  . TYR A 1 565 ? 26.42500 -12.58300 28.60800 1.000 22.44351 ? 559 TYR A OH  1 
ATOM   4140 N  N   . ILE A 1 566 ? 19.31500 -14.23300 27.07600 1.000 20.90903 ? 560 ILE A N   1 
ATOM   4141 C  CA  . ILE A 1 566 ? 18.60700 -13.00000 26.73900 1.000 20.14681 ? 560 ILE A CA  1 
ATOM   4142 C  C   . ILE A 1 566 ? 17.67000 -12.59500 27.87100 1.000 22.57173 ? 560 ILE A C   1 
ATOM   4143 O  O   . ILE A 1 566 ? 17.56800 -11.41200 28.22900 1.000 24.96700 ? 560 ILE A O   1 
ATOM   4144 C  CB  . ILE A 1 566 ? 17.83300 -13.17700 25.42000 1.000 22.75034 ? 560 ILE A CB  1 
ATOM   4145 C  CG1 . ILE A 1 566 ? 18.77300 -13.14100 24.21700 1.000 21.75884 ? 560 ILE A CG1 1 
ATOM   4146 C  CG2 . ILE A 1 566 ? 16.72900 -12.09600 25.27800 1.000 23.31981 ? 560 ILE A CG2 1 
ATOM   4147 C  CD1 . ILE A 1 566 ? 18.07300 -13.59000 22.86800 1.000 21.24106 ? 560 ILE A CD1 1 
ATOM   4148 N  N   . LYS A 1 567 ? 16.97500 -13.56700 28.45800 1.000 18.23675 ? 561 LYS A N   1 
ATOM   4149 C  CA  . LYS A 1 567 ? 16.04000 -13.24300 29.52900 1.000 19.15328 ? 561 LYS A CA  1 
ATOM   4150 C  C   . LYS A 1 567 ? 16.76000 -12.78600 30.79800 1.000 23.23331 ? 561 LYS A C   1 
ATOM   4151 O  O   . LYS A 1 567 ? 16.18700 -12.02100 31.58000 1.000 23.17545 ? 561 LYS A O   1 
ATOM   4152 C  CB  . LYS A 1 567 ? 15.15500 -14.45400 29.81400 1.000 22.08748 ? 561 LYS A CB  1 
ATOM   4153 C  CG  . LYS A 1 567 ? 14.14600 -14.74900 28.68900 1.000 21.15176 ? 561 LYS A CG  1 
ATOM   4154 C  CD  . LYS A 1 567 ? 13.12600 -15.79400 29.12200 1.000 26.02348 ? 561 LYS A CD  1 
ATOM   4155 C  CE  . LYS A 1 567 ? 13.81200 -17.09500 29.56500 1.000 26.14291 ? 561 LYS A CE  1 
ATOM   4156 N  NZ  . LYS A 1 567 ? 12.85100 -18.08000 30.14800 1.000 28.91519 ? 561 LYS A NZ  1 
ATOM   4157 N  N   . ASN A 1 568 ? 18.01400 -13.22100 31.01900 1.000 19.27950 ? 562 ASN A N   1 
ATOM   4158 C  CA  . ASN A 1 568 ? 18.67100 -13.02800 32.31700 1.000 20.03885 ? 562 ASN A CA  1 
ATOM   4159 C  C   . ASN A 1 568 ? 19.79100 -11.98700 32.35900 1.000 22.56978 ? 562 ASN A C   1 
ATOM   4160 O  O   . ASN A 1 568 ? 20.12800 -11.51800 33.45600 1.000 23.94026 ? 562 ASN A O   1 
ATOM   4161 C  CB  . ASN A 1 568 ? 19.29300 -14.34800 32.80900 1.000 21.58268 ? 562 ASN A CB  1 
ATOM   4162 C  CG  . ASN A 1 568 ? 18.26000 -15.39800 33.13300 1.000 24.60708 ? 562 ASN A CG  1 
ATOM   4163 O  OD1 . ASN A 1 568 ? 17.09300 -15.08900 33.40900 1.000 26.17233 ? 562 ASN A OD1 1 
ATOM   4164 N  ND2 . ASN A 1 568 ? 18.68500 -16.65600 33.11600 1.000 17.27418 ? 562 ASN A ND2 1 
ATOM   4165 N  N   . VAL A 1 569 ? 20.40600 -11.64400 31.23400 1.000 20.61822 ? 563 VAL A N   1 
ATOM   4166 C  CA  . VAL A 1 569 ? 21.70600 -10.96400 31.28200 1.000 18.92273 ? 563 VAL A CA  1 
ATOM   4167 C  C   . VAL A 1 569 ? 21.53300 -9.46500  31.50400 1.000 22.94210 ? 563 VAL A C   1 
ATOM   4168 O  O   . VAL A 1 569 ? 20.65400 -8.81400  30.92200 1.000 20.52692 ? 563 VAL A O   1 
ATOM   4169 C  CB  . VAL A 1 569 ? 22.51800 -11.25300 30.00200 1.000 18.54765 ? 563 VAL A CB  1 
ATOM   4170 C  CG1 . VAL A 1 569 ? 21.87100 -10.63400 28.74700 1.000 21.49464 ? 563 VAL A CG1 1 
ATOM   4171 C  CG2 . VAL A 1 569 ? 23.96700 -10.78700 30.16100 1.000 22.33110 ? 563 VAL A CG2 1 
ATOM   4172 N  N   . GLN A 1 570 ? 22.38800 -8.91000  32.35500 1.000 21.30944 ? 564 GLN A N   1 
ATOM   4173 C  CA  . GLN A 1 570 ? 22.47100 -7.48100  32.55300 1.000 20.75724 ? 564 GLN A CA  1 
ATOM   4174 C  C   . GLN A 1 570 ? 23.43300 -6.87800  31.53000 1.000 24.79559 ? 564 GLN A C   1 
ATOM   4175 O  O   . GLN A 1 570 ? 24.05200 -7.58300  30.72600 1.000 19.88625 ? 564 GLN A O   1 
ATOM   4176 C  CB  . GLN A 1 570 ? 22.92800 -7.17300  33.97100 1.000 19.46204 ? 564 GLN A CB  1 
ATOM   4177 C  CG  . GLN A 1 570 ? 22.05800 -7.77900  35.05100 1.000 24.80822 ? 564 GLN A CG  1 
ATOM   4178 C  CD  . GLN A 1 570 ? 20.65000 -7.24900  35.04700 1.000 29.64763 ? 564 GLN A CD  1 
ATOM   4179 O  OE1 . GLN A 1 570 ? 20.40800 -6.11000  34.64100 1.000 34.34595 ? 564 GLN A OE1 1 
ATOM   4180 N  NE2 . GLN A 1 570 ? 19.70300 -8.06400  35.51000 1.000 30.91980 ? 564 GLN A NE2 1 
ATOM   4181 N  N   . SER A 1 571 ? 23.57800 -5.55600  31.57500 1.000 19.83141 ? 565 SER A N   1 
ATOM   4182 C  CA  . SER A 1 571 ? 24.35400 -4.87800  30.55400 1.000 25.13582 ? 565 SER A CA  1 
ATOM   4183 C  C   . SER A 1 571 ? 25.84500 -5.15500  30.73000 1.000 23.09169 ? 565 SER A C   1 
ATOM   4184 O  O   . SER A 1 571 ? 26.31400 -5.63000  31.77600 1.000 22.12847 ? 565 SER A O   1 
ATOM   4185 C  CB  . SER A 1 571 ? 24.11600 -3.37700  30.60600 1.000 20.66478 ? 565 SER A CB  1 
ATOM   4186 O  OG  . SER A 1 571 ? 24.73500 -2.89000  31.75800 1.000 22.67586 ? 565 SER A OG  1 
ATOM   4187 N  N   . ALA A 1 572 ? 26.59200 -4.83000  29.67000 1.000 21.72816 ? 566 ALA A N   1 
ATOM   4188 C  CA  . ALA A 1 572 ? 28.04400 -4.94900  29.70500 1.000 19.09571 ? 566 ALA A CA  1 
ATOM   4189 C  C   . ALA A 1 572 ? 28.64900 -4.05700  30.79200 1.000 22.39931 ? 566 ALA A C   1 
ATOM   4190 O  O   . ALA A 1 572 ? 29.58700 -4.45200  31.49200 1.000 21.25690 ? 566 ALA A O   1 
ATOM   4191 C  CB  . ALA A 1 572 ? 28.60200 -4.60100  28.32500 1.000 19.54497 ? 566 ALA A CB  1 
ATOM   4192 N  N   . SER A 1 573 ? 28.10400 -2.86000  30.97600 1.000 19.55637 ? 567 SER A N   1 
ATOM   4193 C  CA  . SER A 1 573 ? 28.58700 -2.02800  32.07000 1.000 22.45523 ? 567 SER A CA  1 
ATOM   4194 C  C   . SER A 1 573 ? 28.33500 -2.67600  33.42500 1.000 24.36586 ? 567 SER A C   1 
ATOM   4195 O  O   . SER A 1 573 ? 29.05100 -2.37800  34.38800 1.000 22.67023 ? 567 SER A O   1 
ATOM   4196 C  CB  . SER A 1 573 ? 27.92300 -0.65000  31.99900 1.000 23.98119 ? 567 SER A CB  1 
ATOM   4197 O  OG  . SER A 1 573 ? 28.27800 0.00200   30.78500 1.000 26.28336 ? 567 SER A OG  1 
ATOM   4198 N  N   . ASP A 1 574 ? 27.33900 -3.55800  33.52000 1.000 22.88921 ? 568 ASP A N   1 
ATOM   4199 C  CA  . ASP A 1 574 ? 27.07200 -4.32600  34.73000 1.000 23.52445 ? 568 ASP A CA  1 
ATOM   4200 C  C   . ASP A 1 574 ? 27.76200 -5.69100  34.71000 1.000 27.41103 ? 568 ASP A C   1 
ATOM   4201 O  O   . ASP A 1 574 ? 27.36800 -6.59400  35.46400 1.000 24.20695 ? 568 ASP A O   1 
ATOM   4202 C  CB  . ASP A 1 574 ? 25.55600 -4.49200  34.92700 1.000 20.06232 ? 568 ASP A CB  1 
ATOM   4203 C  CG  . ASP A 1 574 ? 24.85900 -3.16900  35.30100 1.000 27.31081 ? 568 ASP A CG  1 
ATOM   4204 O  OD1 . ASP A 1 574 ? 25.55000 -2.24500  35.76400 1.000 31.05920 ? 568 ASP A OD1 1 
ATOM   4205 O  OD2 . ASP A 1 574 ? 23.62300 -3.05400  35.14600 1.000 28.38203 ? 568 ASP A OD2 1 
ATOM   4206 N  N   . GLY A 1 575 ? 28.77900 -5.86200  33.86700 1.000 25.86053 ? 569 GLY A N   1 
ATOM   4207 C  CA  . GLY A 1 575 ? 29.51200 -7.11800  33.81000 1.000 20.05455 ? 569 GLY A CA  1 
ATOM   4208 C  C   . GLY A 1 575 ? 28.75700 -8.28800  33.21100 1.000 22.40504 ? 569 GLY A C   1 
ATOM   4209 O  O   . GLY A 1 575 ? 29.22100 -9.42100  33.33000 1.000 19.96449 ? 569 GLY A O   1 
ATOM   4210 N  N   . CYS A 1 576 ? 27.61600 -8.05200  32.56100 1.000 18.45825 ? 570 CYS A N   1 
ATOM   4211 C  CA  . CYS A 1 576 ? 26.79100 -9.12700  31.98800 1.000 22.16636 ? 570 CYS A CA  1 
ATOM   4212 C  C   . CYS A 1 576 ? 26.49700 -10.23900 32.99800 1.000 20.54811 ? 570 CYS A C   1 
ATOM   4213 O  O   . CYS A 1 576 ? 26.44800 -11.42100 32.64800 1.000 21.81527 ? 570 CYS A O   1 
ATOM   4214 C  CB  . CYS A 1 576 ? 27.43300 -9.71000  30.72400 1.000 20.57996 ? 570 CYS A CB  1 
ATOM   4215 S  SG  . CYS A 1 576 ? 27.59000 -8.51900  29.38600 1.000 20.69953 ? 570 CYS A SG  1 
ATOM   4216 N  N   . VAL A 1 577 ? 26.28400 -9.86000  34.26600 1.000 22.25685 ? 571 VAL A N   1 
ATOM   4217 C  CA  . VAL A 1 577 ? 25.82900 -10.84400 35.24100 1.000 21.80466 ? 571 VAL A CA  1 
ATOM   4218 C  C   . VAL A 1 577 ? 24.41900 -11.29000 34.87700 1.000 20.74399 ? 571 VAL A C   1 
ATOM   4219 O  O   . VAL A 1 577 ? 23.64700 -10.56000 34.23100 1.000 22.12680 ? 571 VAL A O   1 
ATOM   4220 C  CB  . VAL A 1 577 ? 25.87300 -10.30500 36.68700 1.000 22.24998 ? 571 VAL A CB  1 
ATOM   4221 C  CG1 . VAL A 1 577 ? 27.30200 -10.03100 37.12700 1.000 21.00609 ? 571 VAL A CG1 1 
ATOM   4222 C  CG2 . VAL A 1 577 ? 25.02100 -9.05000  36.83300 1.000 17.88437 ? 571 VAL A CG2 1 
ATOM   4223 N  N   . THR A 1 578 ? 24.06800 -12.50500 35.30200 1.000 19.32153 ? 572 THR A N   1 
ATOM   4224 C  CA  . THR A 1 578 ? 22.81500 -13.12300 34.90000 1.000 20.49894 ? 572 THR A CA  1 
ATOM   4225 C  C   . THR A 1 578 ? 21.91300 -13.50200 36.06900 1.000 20.88224 ? 572 THR A C   1 
ATOM   4226 O  O   . THR A 1 578 ? 20.78000 -13.94000 35.83300 1.000 21.62840 ? 572 THR A O   1 
ATOM   4227 C  CB  . THR A 1 578 ? 23.08100 -14.38700 34.06800 1.000 19.15225 ? 572 THR A CB  1 
ATOM   4228 O  OG1 . THR A 1 578 ? 23.72700 -15.35800 34.89800 1.000 20.91742 ? 572 THR A OG1 1 
ATOM   4229 C  CG2 . THR A 1 578 ? 24.00000 -14.09100 32.86600 1.000 20.65434 ? 572 THR A CG2 1 
ATOM   4230 N  N   . ASP A 1 579 ? 22.37400 -13.36500 37.30600 1.000 20.25046 ? 573 ASP A N   1 
ATOM   4231 C  CA  . ASP A 1 579 ? 21.64700 -13.86300 38.46800 1.000 21.40611 ? 573 ASP A CA  1 
ATOM   4232 C  C   . ASP A 1 579 ? 21.12000 -12.74200 39.35500 1.000 24.26557 ? 573 ASP A C   1 
ATOM   4233 O  O   . ASP A 1 579 ? 21.03200 -12.90300 40.58400 1.000 23.60512 ? 573 ASP A O   1 
ATOM   4234 C  CB  . ASP A 1 579 ? 22.54800 -14.77900 39.28500 1.000 17.84142 ? 573 ASP A CB  1 
ATOM   4235 C  CG  . ASP A 1 579 ? 23.70300 -14.02900 39.91900 1.000 22.48086 ? 573 ASP A CG  1 
ATOM   4236 O  OD1 . ASP A 1 579 ? 24.15600 -13.01500 39.31800 1.000 19.50409 ? 573 ASP A OD1 1 
ATOM   4237 O  OD2 . ASP A 1 579 ? 24.15800 -14.44000 41.00700 1.000 20.84407 ? 573 ASP A OD2 1 
ATOM   4238 N  N   . GLU A 1 580 ? 20.79200 -11.59500 38.76500 1.000 20.50402 ? 574 GLU A N   1 
ATOM   4239 C  CA  . GLU A 1 580 ? 20.29300 -10.48900 39.57300 1.000 23.54670 ? 574 GLU A CA  1 
ATOM   4240 C  C   . GLU A 1 580 ? 18.86400 -10.10500 39.18100 1.000 28.85132 ? 574 GLU A C   1 
ATOM   4241 O  O   . GLU A 1 580 ? 18.23400 -9.29400  39.85200 1.000 31.51278 ? 574 GLU A O   1 
ATOM   4242 C  CB  . GLU A 1 580 ? 21.25900 -9.29500  39.47800 1.000 23.97771 ? 574 GLU A CB  1 
ATOM   4243 C  CG  . GLU A 1 580 ? 22.64600 -9.64900  40.05800 1.000 24.32253 ? 574 GLU A CG  1 
ATOM   4244 C  CD  . GLU A 1 580 ? 23.56700 -8.44900  40.31900 1.000 30.36609 ? 574 GLU A CD  1 
ATOM   4245 O  OE1 . GLU A 1 580 ? 23.12500 -7.27600  40.29100 1.000 29.31237 ? 574 GLU A OE1 1 
ATOM   4246 O  OE2 . GLU A 1 580 ? 24.75900 -8.69100  40.55100 1.000 24.60487 ? 574 GLU A OE2 1 
ATOM   4247 O  OXT . GLU A 1 580 ? 18.28700 -10.62800 38.22100 1.000 28.33672 ? 574 GLU A OXT 1 
HETATM 4248 MG MG  . MG  B 2 .   ? 37.67100 -14.56100 25.04000 1.000 55.89348 ? 601 MG  A MG  1 
HETATM 4249 S  S   . SO4 C 3 .   ? 28.04900 -18.74100 10.73500 1.000 51.84547 ? 602 SO4 A S   1 
HETATM 4250 O  O1  . SO4 C 3 .   ? 28.67400 -18.64100 9.44300  1.000 55.94625 ? 602 SO4 A O1  1 
HETATM 4251 O  O2  . SO4 C 3 .   ? 26.83000 -19.50600 10.63300 1.000 47.87035 ? 602 SO4 A O2  1 
HETATM 4252 O  O3  . SO4 C 3 .   ? 28.94600 -19.41100 11.65000 1.000 33.66049 ? 602 SO4 A O3  1 
HETATM 4253 O  O4  . SO4 C 3 .   ? 27.74600 -17.42100 11.21600 1.000 51.67374 ? 602 SO4 A O4  1 
HETATM 4254 C  C11 . K0O D 4 .   ? 41.09600 -16.16600 21.33000 0.890 45.12306 ? 603 K0O A C11 1 
HETATM 4255 C  C12 . K0O D 4 .   ? 41.16400 -15.55900 22.75500 0.890 52.82996 ? 603 K0O A C12 1 
HETATM 4256 C  C13 . K0O D 4 .   ? 40.24600 -14.31000 22.87800 0.890 50.70578 ? 603 K0O A C13 1 
HETATM 4257 C  C15 . K0O D 4 .   ? 40.73900 -13.28400 24.04300 0.890 50.27846 ? 603 K0O A C15 1 
HETATM 4258 O  O16 . K0O D 4 .   ? 40.82700 -12.08500 23.80600 0.890 43.91567 ? 603 K0O A O16 1 
HETATM 4259 C  C18 . K0O D 4 .   ? 40.12800 -13.58800 21.50200 0.890 50.58583 ? 603 K0O A C18 1 
HETATM 4260 C  C19 . K0O D 4 .   ? 41.31100 -13.33400 20.49100 0.890 51.64797 ? 603 K0O A C19 1 
HETATM 4261 C  C01 . K0O D 4 .   ? 42.04300 -14.44300 19.69300 0.890 53.60744 ? 603 K0O A C01 1 
HETATM 4262 C  C02 . K0O D 4 .   ? 42.35600 -15.63200 20.65400 0.890 52.97413 ? 603 K0O A C02 1 
HETATM 4263 C  C03 . K0O D 4 .   ? 43.13900 -16.56900 19.76700 0.890 52.89643 ? 603 K0O A C03 1 
HETATM 4264 C  C04 . K0O D 4 .   ? 44.06600 -15.60200 18.98900 0.890 54.15535 ? 603 K0O A C04 1 
HETATM 4265 C  C05 . K0O D 4 .   ? 43.38800 -14.23300 18.94700 0.890 56.43899 ? 603 K0O A C05 1 
HETATM 4266 C  C06 . K0O D 4 .   ? 43.71900 -13.28700 18.02300 0.890 58.87289 ? 603 K0O A C06 1 
HETATM 4267 C  C07 . K0O D 4 .   ? 43.58100 -11.81600 18.30700 0.890 57.35481 ? 603 K0O A C07 1 
HETATM 4268 C  C08 . K0O D 4 .   ? 44.74700 -13.54100 16.96000 0.890 56.43041 ? 603 K0O A C08 1 
HETATM 4269 C  C09 . K0O D 4 .   ? 43.25000 -15.22800 21.82200 0.890 54.46483 ? 603 K0O A C09 1 
HETATM 4270 O  O10 . K0O D 4 .   ? 42.48400 -15.18900 23.01900 0.890 51.85095 ? 603 K0O A O10 1 
HETATM 4271 O  O14 . K0O D 4 .   ? 39.01400 -14.78300 23.30200 0.890 39.63787 ? 603 K0O A O14 1 
HETATM 4272 O  O17 . K0O D 4 .   ? 41.01200 -13.82500 25.14900 0.890 51.45429 ? 603 K0O A O17 1 
HETATM 4273 C  C11 . K0O E 4 .   ? 19.06600 -17.80800 13.22200 1.000 47.52016 ? 604 K0O A C11 1 
HETATM 4274 C  C12 . K0O E 4 .   ? 19.69000 -18.29400 11.88900 1.000 50.13685 ? 604 K0O A C12 1 
HETATM 4275 C  C13 . K0O E 4 .   ? 19.86200 -19.84800 11.84700 1.000 51.75139 ? 604 K0O A C13 1 
HETATM 4276 C  C15 . K0O E 4 .   ? 20.96600 -20.20200 10.75400 1.000 52.32238 ? 604 K0O A C15 1 
HETATM 4277 O  O16 . K0O E 4 .   ? 20.66500 -19.91500 9.55000  1.000 56.43091 ? 604 K0O A O16 1 
HETATM 4278 C  C18 . K0O E 4 .   ? 20.26400 -20.45100 13.25900 1.000 44.26186 ? 604 K0O A C18 1 
HETATM 4279 C  C19 . K0O E 4 .   ? 21.15400 -19.70100 14.37500 1.000 41.51252 ? 604 K0O A C19 1 
HETATM 4280 C  C01 . K0O E 4 .   ? 20.67200 -18.44100 15.14000 1.000 44.88881 ? 604 K0O A C01 1 
HETATM 4281 C  C02 . K0O E 4 .   ? 20.27000 -17.34700 14.06800 1.000 43.96354 ? 604 K0O A C02 1 
HETATM 4282 C  C03 . K0O E 4 .   ? 20.11600 -16.07500 14.88400 1.000 34.51601 ? 604 K0O A C03 1 
HETATM 4283 C  C04 . K0O E 4 .   ? 21.17300 -16.20800 16.03100 1.000 39.19130 ? 604 K0O A C04 1 
HETATM 4284 C  C05 . K0O E 4 .   ? 21.52100 -17.69100 16.19700 1.000 34.19055 ? 604 K0O A C05 1 
HETATM 4285 C  C06 . K0O E 4 .   ? 22.28500 -18.17300 17.21400 1.000 40.19659 ? 604 K0O A C06 1 
HETATM 4286 C  C07 . K0O E 4 .   ? 22.45000 -19.66200 17.51500 1.000 31.22781 ? 604 K0O A C07 1 
HETATM 4287 C  C08 . K0O E 4 .   ? 23.16400 -17.25800 18.03700 1.000 34.94267 ? 604 K0O A C08 1 
HETATM 4288 C  C09 . K0O E 4 .   ? 21.37800 -17.12400 12.98600 1.000 43.15691 ? 604 K0O A C09 1 
HETATM 4289 O  O10 . K0O E 4 .   ? 20.96500 -17.71900 11.74600 1.000 45.99618 ? 604 K0O A O10 1 
HETATM 4290 O  O14 . K0O E 4 .   ? 18.67000 -20.40300 11.36700 1.000 54.86429 ? 604 K0O A O14 1 
HETATM 4291 O  O17 . K0O E 4 .   ? 22.01300 -20.72200 11.14900 1.000 53.39631 ? 604 K0O A O17 1 
HETATM 4292 FE FE1 . FES F 5 .   ? 42.50000 -18.86600 24.38400 0.698 45.50850 ? 605 FES A FE1 1 
HETATM 4293 FE FE2 . FES F 5 .   ? 41.34400 -20.99900 25.57800 0.698 32.02489 ? 605 FES A FE2 1 
HETATM 4294 S  S1  . FES F 5 .   ? 42.70000 -19.49400 26.50200 0.698 46.92792 ? 605 FES A S1  1 
HETATM 4295 S  S2  . FES F 5 .   ? 40.88000 -20.16000 23.60000 0.698 30.31858 ? 605 FES A S2  1 
HETATM 4296 O  O   . HOH G 6 .   ? 39.39000 -7.90800  16.86900 1.000 43.87179 ? 701 HOH A O   1 
HETATM 4297 O  O   . HOH G 6 .   ? 36.10600 0.48200   -2.74900 1.000 40.12746 ? 702 HOH A O   1 
HETATM 4298 O  O   . HOH G 6 .   ? 32.00400 -35.81900 62.03800 1.000 41.18687 ? 703 HOH A O   1 
HETATM 4299 O  O   . HOH G 6 .   ? 54.65600 -7.91000  55.85100 1.000 46.61369 ? 704 HOH A O   1 
HETATM 4300 O  O   . HOH G 6 .   ? 16.69000 11.86100  11.80000 1.000 49.30825 ? 705 HOH A O   1 
HETATM 4301 O  O   . HOH G 6 .   ? 34.85200 6.71200   33.96400 1.000 39.17783 ? 706 HOH A O   1 
HETATM 4302 O  O   . HOH G 6 .   ? 59.76900 -14.96500 41.62400 1.000 39.32066 ? 707 HOH A O   1 
HETATM 4303 O  O   . HOH G 6 .   ? 49.13600 -13.63400 57.91300 1.000 48.25041 ? 708 HOH A O   1 
HETATM 4304 O  O   . HOH G 6 .   ? 31.86100 4.31700   40.82600 1.000 37.56206 ? 709 HOH A O   1 
HETATM 4305 O  O   . HOH G 6 .   ? 26.21700 -14.38700 35.83500 1.000 19.23246 ? 710 HOH A O   1 
HETATM 4306 O  O   . HOH G 6 .   ? 41.12300 -42.70100 57.13600 1.000 49.58201 ? 711 HOH A O   1 
HETATM 4307 O  O   . HOH G 6 .   ? 15.722   -9.411    39.890   1.000 36.80432 ? 712 HOH A O   1 
HETATM 4308 O  O   . HOH G 6 .   ? 42.85400 -16.42200 25.62100 1.000 38.25192 ? 713 HOH A O   1 
HETATM 4309 O  O   . HOH G 6 .   ? 39.53500 -38.94200 48.21000 1.000 30.32019 ? 714 HOH A O   1 
HETATM 4310 O  O   . HOH G 6 .   ? 27.70300 -13.02800 30.74500 1.000 20.45359 ? 715 HOH A O   1 
HETATM 4311 O  O   . HOH G 6 .   ? 24.05400 -19.80100 12.34000 1.000 45.35273 ? 716 HOH A O   1 
HETATM 4312 O  O   . HOH G 6 .   ? 22.30500 -5.16200  27.44800 1.000 28.48933 ? 717 HOH A O   1 
HETATM 4313 O  O   . HOH G 6 .   ? 38.57300 -19.32600 15.01800 1.000 31.76460 ? 718 HOH A O   1 
HETATM 4314 O  O   . HOH G 6 .   ? 40.45800 1.17100   13.75100 1.000 44.44052 ? 719 HOH A O   1 
HETATM 4315 O  O   . HOH G 6 .   ? 46.03800 -31.18100 46.26500 1.000 24.06109 ? 720 HOH A O   1 
HETATM 4316 O  O   . HOH G 6 .   ? 43.13000 7.47900   39.83700 1.000 39.88944 ? 721 HOH A O   1 
HETATM 4317 O  O   . HOH G 6 .   ? 40.75700 5.21500   14.12700 1.000 38.61172 ? 722 HOH A O   1 
HETATM 4318 O  O   . HOH G 6 .   ? 21.90800 -3.89100  33.42300 1.000 24.62643 ? 723 HOH A O   1 
HETATM 4319 O  O   . HOH G 6 .   ? 50.64600 1.78200   25.21700 1.000 49.58947 ? 724 HOH A O   1 
HETATM 4320 O  O   . HOH G 6 .   ? 25.76800 -11.06200 40.59100 1.000 23.86717 ? 725 HOH A O   1 
HETATM 4321 O  O   . HOH G 6 .   ? 34.72900 -12.46200 13.99700 1.000 29.26276 ? 726 HOH A O   1 
HETATM 4322 O  O   . HOH G 6 .   ? 23.83800 9.79900   15.65300 1.000 31.68143 ? 727 HOH A O   1 
HETATM 4323 O  O   . HOH G 6 .   ? 34.37000 -9.27600  50.70900 1.000 28.54075 ? 728 HOH A O   1 
HETATM 4324 O  O   . HOH G 6 .   ? 33.31100 -21.52600 47.71000 1.000 26.25615 ? 729 HOH A O   1 
HETATM 4325 O  O   . HOH G 6 .   ? 49.83200 -18.31600 22.53900 1.000 51.42167 ? 730 HOH A O   1 
HETATM 4326 O  O   . HOH G 6 .   ? 34.23400 14.88300  29.58500 1.000 40.39057 ? 731 HOH A O   1 
HETATM 4327 O  O   . HOH G 6 .   ? 33.46500 -14.14500 16.13300 1.000 25.30004 ? 732 HOH A O   1 
HETATM 4328 O  O   . HOH G 6 .   ? 24.23000 -5.42600  38.82400 1.000 31.01051 ? 733 HOH A O   1 
HETATM 4329 O  O   . HOH G 6 .   ? 20.67100 -4.39800  14.53000 1.000 42.60573 ? 734 HOH A O   1 
HETATM 4330 O  O   . HOH G 6 .   ? 28.31900 -28.31900 33.32000 0.50  27.73970 ? 735 HOH A O   1 
HETATM 4331 O  O   . HOH G 6 .   ? 58.73500 2.99100   25.22800 1.000 59.38946 ? 736 HOH A O   1 
HETATM 4332 O  O   . HOH G 6 .   ? 45.50000 7.70800   22.20800 1.000 49.61615 ? 737 HOH A O   1 
HETATM 4333 O  O   . HOH G 6 .   ? 26.63700 -14.12100 41.77700 1.000 24.33092 ? 738 HOH A O   1 
HETATM 4334 O  O   . HOH G 6 .   ? 22.52500 -5.07400  20.58000 1.000 24.24783 ? 739 HOH A O   1 
HETATM 4335 O  O   . HOH G 6 .   ? 13.82800 5.41400   14.55400 1.000 45.78450 ? 740 HOH A O   1 
HETATM 4336 O  O   . HOH G 6 .   ? 17.70800 -9.26900  18.10900 1.000 30.66627 ? 741 HOH A O   1 
HETATM 4337 O  O   . HOH G 6 .   ? 45.39800 -24.19800 31.02000 1.000 32.46238 ? 742 HOH A O   1 
HETATM 4338 O  O   . HOH G 6 .   ? 51.66100 -14.04300 43.79300 1.000 31.23916 ? 743 HOH A O   1 
HETATM 4339 O  O   . HOH G 6 .   ? 35.89400 -24.02900 58.24400 1.000 26.96172 ? 744 HOH A O   1 
HETATM 4340 O  O   . HOH G 6 .   ? 45.41900 -22.99900 23.56400 1.000 35.44845 ? 745 HOH A O   1 
HETATM 4341 O  O   . HOH G 6 .   ? 29.30900 -36.49700 47.00700 1.000 25.43423 ? 746 HOH A O   1 
HETATM 4342 O  O   . HOH G 6 .   ? 21.56200 -21.69400 34.74600 1.000 34.27549 ? 747 HOH A O   1 
HETATM 4343 O  O   . HOH G 6 .   ? 42.26400 -34.17300 22.90500 1.000 36.74345 ? 748 HOH A O   1 
HETATM 4344 O  O   . HOH G 6 .   ? 36.27400 -6.77200  25.43900 1.000 24.46416 ? 749 HOH A O   1 
HETATM 4345 O  O   . HOH G 6 .   ? 20.17400 17.22500  14.07400 1.000 44.49758 ? 750 HOH A O   1 
HETATM 4346 O  O   . HOH G 6 .   ? 52.03100 -26.53200 26.03100 1.000 39.49591 ? 751 HOH A O   1 
HETATM 4347 O  O   . HOH G 6 .   ? 45.47800 -2.01200  45.43500 1.000 39.54839 ? 752 HOH A O   1 
HETATM 4348 O  O   . HOH G 6 .   ? 25.30300 -27.46100 50.73700 1.000 22.86924 ? 753 HOH A O   1 
HETATM 4349 O  O   . HOH G 6 .   ? 30.25300 -8.15100  -0.61900 1.000 46.99958 ? 754 HOH A O   1 
HETATM 4350 O  O   . HOH G 6 .   ? 20.48300 -10.58600 35.91000 1.000 22.80027 ? 755 HOH A O   1 
HETATM 4351 O  O   . HOH G 6 .   ? 42.95600 -24.21000 5.89800  1.000 45.04323 ? 756 HOH A O   1 
HETATM 4352 O  O   . HOH G 6 .   ? 23.03800 0.37600   30.04100 1.000 30.43614 ? 757 HOH A O   1 
HETATM 4353 O  O   . HOH G 6 .   ? 24.06800 15.26000  20.28800 1.000 36.45312 ? 758 HOH A O   1 
HETATM 4354 O  O   . HOH G 6 .   ? 37.85000 -14.40500 12.43700 1.000 46.23258 ? 759 HOH A O   1 
HETATM 4355 O  O   . HOH G 6 .   ? 31.08600 -20.88100 54.54500 1.000 23.83547 ? 760 HOH A O   1 
HETATM 4356 O  O   . HOH G 6 .   ? 22.95200 10.01400  25.10700 1.000 38.28498 ? 761 HOH A O   1 
HETATM 4357 O  O   . HOH G 6 .   ? 25.23300 -17.68600 36.48500 1.000 17.97963 ? 762 HOH A O   1 
HETATM 4358 O  O   . HOH G 6 .   ? 34.73700 -26.33700 57.19800 1.000 24.56865 ? 763 HOH A O   1 
HETATM 4359 O  O   . HOH G 6 .   ? 46.94100 -26.92700 58.18700 1.000 34.00963 ? 764 HOH A O   1 
HETATM 4360 O  O   . HOH G 6 .   ? 31.92100 -20.90800 58.23600 1.000 40.58714 ? 765 HOH A O   1 
HETATM 4361 O  O   . HOH G 6 .   ? 33.71900 -30.80400 29.76000 1.000 17.42013 ? 766 HOH A O   1 
HETATM 4362 O  O   . HOH G 6 .   ? 31.95000 -34.98200 57.08200 1.000 26.84403 ? 767 HOH A O   1 
HETATM 4363 O  O   . HOH G 6 .   ? 36.78700 -33.10200 59.82300 1.000 34.74967 ? 768 HOH A O   1 
HETATM 4364 O  O   . HOH G 6 .   ? 37.61600 -2.09100  44.61400 1.000 34.45335 ? 769 HOH A O   1 
HETATM 4365 O  O   . HOH G 6 .   ? 31.65200 -9.39800  50.73300 1.000 29.25641 ? 770 HOH A O   1 
HETATM 4366 O  O   . HOH G 6 .   ? 25.50400 -12.86200 16.13000 1.000 45.15804 ? 771 HOH A O   1 
HETATM 4367 O  O   . HOH G 6 .   ? 46.52400 -22.11100 43.03100 1.000 21.11507 ? 772 HOH A O   1 
HETATM 4368 O  O   . HOH G 6 .   ? 50.12200 -6.36500  27.38300 1.000 47.41619 ? 773 HOH A O   1 
HETATM 4369 O  O   . HOH G 6 .   ? 43.57400 -34.56400 31.01100 1.000 27.54816 ? 774 HOH A O   1 
HETATM 4370 O  O   . HOH G 6 .   ? 26.54900 -13.92800 38.42700 1.000 18.34822 ? 775 HOH A O   1 
HETATM 4371 O  O   . HOH G 6 .   ? 47.22900 -1.38100  30.39900 1.000 39.46705 ? 776 HOH A O   1 
HETATM 4372 O  O   . HOH G 6 .   ? 25.16300 -18.37500 49.48900 1.000 25.21758 ? 777 HOH A O   1 
HETATM 4373 O  O   . HOH G 6 .   ? 14.66300 -6.08900  23.21200 1.000 39.59162 ? 778 HOH A O   1 
HETATM 4374 O  O   . HOH G 6 .   ? 50.83800 -20.01200 32.90900 1.000 31.11458 ? 779 HOH A O   1 
HETATM 4375 O  O   . HOH G 6 .   ? 24.76900 -8.70000  9.60500  1.000 37.55243 ? 780 HOH A O   1 
HETATM 4376 O  O   . HOH G 6 .   ? 39.33900 -1.81500  22.21600 1.000 36.86801 ? 781 HOH A O   1 
HETATM 4377 O  O   . HOH G 6 .   ? 22.65400 -18.15200 50.95500 1.000 27.54255 ? 782 HOH A O   1 
HETATM 4378 O  O   . HOH G 6 .   ? 28.50100 -27.28300 60.78300 1.000 33.16585 ? 783 HOH A O   1 
HETATM 4379 O  O   . HOH G 6 .   ? 44.41400 4.30200   2.34400  1.000 48.93104 ? 784 HOH A O   1 
HETATM 4380 O  O   . HOH G 6 .   ? 47.90400 -36.98200 37.34300 1.000 37.85545 ? 785 HOH A O   1 
HETATM 4381 O  O   . HOH G 6 .   ? 48.78600 -26.10600 15.50900 1.000 44.97612 ? 786 HOH A O   1 
HETATM 4382 O  O   . HOH G 6 .   ? 45.45700 -9.17400  46.99000 1.000 27.29049 ? 787 HOH A O   1 
HETATM 4383 O  O   . HOH G 6 .   ? 27.81100 16.33100  20.97500 1.000 33.98914 ? 788 HOH A O   1 
HETATM 4384 O  O   . HOH G 6 .   ? 44.02100 -10.93000 48.37400 1.000 27.46231 ? 789 HOH A O   1 
HETATM 4385 O  O   . HOH G 6 .   ? 48.22800 -27.71900 55.74900 1.000 32.47585 ? 790 HOH A O   1 
HETATM 4386 O  O   . HOH G 6 .   ? 34.140   -15.960   9.547    1.000 44.23311 ? 791 HOH A O   1 
HETATM 4387 O  O   . HOH G 6 .   ? 18.05800 -9.45800  30.26400 1.000 30.54079 ? 792 HOH A O   1 
HETATM 4388 O  O   . HOH G 6 .   ? 18.37300 -34.61600 58.25400 1.000 39.50903 ? 793 HOH A O   1 
HETATM 4389 O  O   . HOH G 6 .   ? 27.51000 -15.83100 25.29700 1.000 19.17179 ? 794 HOH A O   1 
HETATM 4390 O  O   . HOH G 6 .   ? 12.19700 -14.99100 20.66900 1.000 31.33395 ? 795 HOH A O   1 
HETATM 4391 O  O   . HOH G 6 .   ? 16.40300 -15.31700 14.15100 1.000 45.11457 ? 796 HOH A O   1 
HETATM 4392 O  O   . HOH G 6 .   ? 33.79200 16.79600  14.45600 1.000 40.32094 ? 797 HOH A O   1 
HETATM 4393 O  O   . HOH G 6 .   ? 47.76400 -14.96000 45.56400 1.000 32.25066 ? 798 HOH A O   1 
HETATM 4394 O  O   . HOH G 6 .   ? 31.74700 -42.28500 60.91800 1.000 33.77480 ? 799 HOH A O   1 
HETATM 4395 O  O   . HOH G 6 .   ? 45.44400 -7.45500  26.23300 1.000 39.86206 ? 800 HOH A O   1 
HETATM 4396 O  O   . HOH G 6 .   ? 46.12100 -31.32800 60.33100 1.000 41.63601 ? 801 HOH A O   1 
HETATM 4397 O  O   . HOH G 6 .   ? 58.82700 -14.26900 23.41000 1.000 53.20605 ? 802 HOH A O   1 
HETATM 4398 O  O   . HOH G 6 .   ? 41.69000 -9.30900  50.88000 1.000 31.81299 ? 803 HOH A O   1 
HETATM 4399 O  O   . HOH G 6 .   ? 38.05100 -32.77700 38.83700 1.000 20.83171 ? 804 HOH A O   1 
HETATM 4400 O  O   . HOH G 6 .   ? 26.80800 -3.50300  25.12100 1.000 23.43130 ? 805 HOH A O   1 
HETATM 4401 O  O   . HOH G 6 .   ? 34.54400 -14.45100 58.01000 1.000 40.07396 ? 806 HOH A O   1 
HETATM 4402 O  O   . HOH G 6 .   ? 19.78800 -20.97100 22.57700 1.000 24.82650 ? 807 HOH A O   1 
HETATM 4403 O  O   . HOH G 6 .   ? 37.26700 -23.53900 27.68900 1.000 24.96365 ? 808 HOH A O   1 
HETATM 4404 O  O   . HOH G 6 .   ? 27.21500 2.62600   33.65000 1.000 41.55135 ? 809 HOH A O   1 
HETATM 4405 O  O   . HOH G 6 .   ? 28.68900 7.04400   5.66400  1.000 41.06619 ? 810 HOH A O   1 
HETATM 4406 O  O   . HOH G 6 .   ? 37.51500 -23.69400 61.20900 1.000 34.80985 ? 811 HOH A O   1 
HETATM 4407 O  O   . HOH G 6 .   ? 32.99300 10.88000  30.03100 1.000 36.55949 ? 812 HOH A O   1 
HETATM 4408 O  O   . HOH G 6 .   ? 10.50000 -1.52100  21.16200 1.000 48.58585 ? 813 HOH A O   1 
HETATM 4409 O  O   . HOH G 6 .   ? 33.51800 -37.03900 54.77300 1.000 28.89205 ? 814 HOH A O   1 
HETATM 4410 O  O   . HOH G 6 .   ? 61.86300 -1.68900  43.68300 1.000 51.41475 ? 815 HOH A O   1 
HETATM 4411 O  O   . HOH G 6 .   ? 34.49600 -19.35200 61.44600 1.000 51.87771 ? 816 HOH A O   1 
HETATM 4412 O  O   . HOH G 6 .   ? 45.51900 -8.15800  57.16300 1.000 42.29177 ? 817 HOH A O   1 
HETATM 4413 O  O   . HOH G 6 .   ? 25.44100 -20.03700 52.40700 1.000 44.62685 ? 818 HOH A O   1 
HETATM 4414 O  O   . HOH G 6 .   ? 26.52500 9.63000   30.64900 1.000 41.85852 ? 819 HOH A O   1 
HETATM 4415 O  O   . HOH G 6 .   ? 48.19600 -32.80600 56.01500 1.000 38.21232 ? 820 HOH A O   1 
HETATM 4416 O  O   . HOH G 6 .   ? 26.74100 -5.37700  3.27600  1.000 47.35717 ? 821 HOH A O   1 
HETATM 4417 O  O   . HOH G 6 .   ? 25.64700 0.61100   5.75000  1.000 37.48637 ? 822 HOH A O   1 
HETATM 4418 O  O   . HOH G 6 .   ? 60.53400 -8.14900  41.73200 1.000 40.57299 ? 823 HOH A O   1 
HETATM 4419 O  O   . HOH G 6 .   ? 49.01200 -38.09700 39.68000 1.000 41.57091 ? 824 HOH A O   1 
HETATM 4420 O  O   . HOH G 6 .   ? 27.40100 -22.09600 51.11800 1.000 25.14795 ? 825 HOH A O   1 
HETATM 4421 O  O   . HOH G 6 .   ? 24.13400 3.42200   23.01000 1.000 22.67495 ? 826 HOH A O   1 
HETATM 4422 O  O   . HOH G 6 .   ? 46.65900 -21.83200 53.10300 1.000 36.32199 ? 827 HOH A O   1 
HETATM 4423 O  O   . HOH G 6 .   ? 26.634   -22.037   9.435    1.000 38.12843 ? 828 HOH A O   1 
HETATM 4424 O  O   . HOH G 6 .   ? 36.86300 -46.54800 59.16500 1.000 35.98753 ? 829 HOH A O   1 
HETATM 4425 O  O   . HOH G 6 .   ? 35.68900 7.88500   31.79200 1.000 34.77762 ? 830 HOH A O   1 
HETATM 4426 O  O   . HOH G 6 .   ? 30.41100 -14.58600 23.54400 1.000 20.38981 ? 831 HOH A O   1 
HETATM 4427 O  O   . HOH G 6 .   ? 23.79000 -0.30400  32.34200 1.000 30.88657 ? 832 HOH A O   1 
HETATM 4428 O  O   . HOH G 6 .   ? 30.29200 14.64100  16.59700 1.000 37.99547 ? 833 HOH A O   1 
HETATM 4429 O  O   . HOH G 6 .   ? 41.72700 -39.11500 35.76500 1.000 39.21469 ? 834 HOH A O   1 
HETATM 4430 O  O   . HOH G 6 .   ? 33.32100 14.07700  21.09600 1.000 42.98771 ? 835 HOH A O   1 
HETATM 4431 O  O   . HOH G 6 .   ? 43.60400 -40.90700 44.46400 1.000 44.05758 ? 836 HOH A O   1 
HETATM 4432 O  O   . HOH G 6 .   ? 20.92500 -6.35200  29.57000 1.000 28.35486 ? 837 HOH A O   1 
HETATM 4433 O  O   . HOH G 6 .   ? 30.33300 -1.09400  29.09400 1.000 23.56668 ? 838 HOH A O   1 
HETATM 4434 O  O   . HOH G 6 .   ? 37.92600 18.66200  23.54000 1.000 36.16658 ? 839 HOH A O   1 
HETATM 4435 O  O   . HOH G 6 .   ? 44.488   -19.954   7.140    1.000 43.66978 ? 840 HOH A O   1 
HETATM 4436 O  O   . HOH G 6 .   ? 28.95300 -35.65300 49.47900 1.000 22.84915 ? 841 HOH A O   1 
HETATM 4437 O  O   . HOH G 6 .   ? 24.66400 -21.50200 59.69400 1.000 41.81686 ? 842 HOH A O   1 
HETATM 4438 O  O   . HOH G 6 .   ? 56.19700 -18.86000 37.38900 1.000 40.01960 ? 843 HOH A O   1 
HETATM 4439 O  O   . HOH G 6 .   ? 31.74600 -3.08700  29.99300 1.000 21.42474 ? 844 HOH A O   1 
HETATM 4440 O  O   . HOH G 6 .   ? 21.20500 8.04900   6.44700  1.000 43.52911 ? 845 HOH A O   1 
HETATM 4441 O  O   . HOH G 6 .   ? 23.63800 -3.77500  7.78800  1.000 38.86473 ? 846 HOH A O   1 
HETATM 4442 O  O   . HOH G 6 .   ? 42.04900 -35.43400 27.28000 1.000 39.78449 ? 847 HOH A O   1 
HETATM 4443 O  O   . HOH G 6 .   ? 41.53900 1.84300   20.36000 1.000 41.44745 ? 848 HOH A O   1 
HETATM 4444 O  O   . HOH G 6 .   ? 33.50200 -25.01300 55.08200 1.000 21.36554 ? 849 HOH A O   1 
HETATM 4445 O  O   . HOH G 6 .   ? 26.86600 -6.82900  44.95800 1.000 32.43028 ? 850 HOH A O   1 
HETATM 4446 O  O   . HOH G 6 .   ? 48.23300 -6.05800  25.33700 1.000 44.90190 ? 851 HOH A O   1 
HETATM 4447 O  O   . HOH G 6 .   ? 31.827   -35.408   42.995   1.000 21.98938 ? 852 HOH A O   1 
HETATM 4448 O  O   . HOH G 6 .   ? 10.11400 -18.06200 23.54500 1.000 40.53757 ? 853 HOH A O   1 
HETATM 4449 O  O   . HOH G 6 .   ? 19.79100 -5.86500  18.16100 1.000 29.92112 ? 854 HOH A O   1 
HETATM 4450 O  O   . HOH G 6 .   ? 27.04000 14.25000  29.14800 1.000 47.83580 ? 855 HOH A O   1 
HETATM 4451 O  O   . HOH G 6 .   ? 18.58900 -11.42900 19.69300 1.000 26.31606 ? 856 HOH A O   1 
HETATM 4452 O  O   . HOH G 6 .   ? 36.39000 -31.45900 62.04900 1.000 31.91267 ? 857 HOH A O   1 
HETATM 4453 O  O   . HOH G 6 .   ? 34.46300 -35.05900 62.30400 1.000 35.86632 ? 858 HOH A O   1 
HETATM 4454 O  O   . HOH G 6 .   ? 34.43500 -21.50900 28.30500 1.000 20.51422 ? 859 HOH A O   1 
HETATM 4455 O  O   . HOH G 6 .   ? 34.40900 9.08000   4.88900  1.000 41.27094 ? 860 HOH A O   1 
HETATM 4456 O  O   . HOH G 6 .   ? 33.00100 -28.74100 27.56500 1.000 28.76668 ? 861 HOH A O   1 
HETATM 4457 O  O   . HOH G 6 .   ? 45.10900 -3.22000  30.50700 1.000 38.46560 ? 862 HOH A O   1 
HETATM 4458 O  O   . HOH G 6 .   ? 43.31800 -7.24100  14.18500 1.000 48.40845 ? 863 HOH A O   1 
HETATM 4459 O  O   . HOH G 6 .   ? 45.76400 -17.94400 38.64400 1.000 20.90452 ? 864 HOH A O   1 
HETATM 4460 O  O   . HOH G 6 .   ? 25.33300 -4.41900  27.10800 1.000 19.73974 ? 865 HOH A O   1 
HETATM 4461 O  O   . HOH G 6 .   ? 45.67600 -15.41700 27.51200 1.000 33.32104 ? 866 HOH A O   1 
HETATM 4462 O  O   . HOH G 6 .   ? 22.53300 10.44800  21.72000 1.000 36.93923 ? 867 HOH A O   1 
HETATM 4463 O  O   . HOH G 6 .   ? 34.15700 -32.50400 63.09600 1.000 38.77987 ? 868 HOH A O   1 
HETATM 4464 O  O   . HOH G 6 .   ? 22.47800 -2.57900  27.27400 1.000 25.27564 ? 869 HOH A O   1 
HETATM 4465 O  O   . HOH G 6 .   ? 25.50100 -16.27700 50.93400 1.000 36.74415 ? 870 HOH A O   1 
HETATM 4466 O  O   . HOH G 6 .   ? 29.47200 0.17800   35.70600 1.000 37.07209 ? 871 HOH A O   1 
HETATM 4467 O  O   . HOH G 6 .   ? 39.21400 11.54000  12.04600 1.000 34.28460 ? 872 HOH A O   1 
HETATM 4468 O  O   . HOH G 6 .   ? 39.99100 -45.57900 56.30200 1.000 45.61868 ? 873 HOH A O   1 
HETATM 4469 O  O   . HOH G 6 .   ? 30.76200 3.91700   36.39100 1.000 27.59283 ? 874 HOH A O   1 
HETATM 4470 O  O   . HOH G 6 .   ? 28.05900 -12.24100 39.87300 1.000 19.37145 ? 875 HOH A O   1 
HETATM 4471 O  O   . HOH G 6 .   ? 50.21700 -14.02700 46.45200 1.000 34.41362 ? 876 HOH A O   1 
HETATM 4472 O  O   . HOH G 6 .   ? 12.06700 8.84800   24.12000 1.000 59.70651 ? 877 HOH A O   1 
HETATM 4473 O  O   . HOH G 6 .   ? 20.65300 -5.72300  40.22300 1.000 37.33379 ? 878 HOH A O   1 
HETATM 4474 O  O   . HOH G 6 .   ? 21.60700 4.12800   8.29100  1.000 42.36548 ? 879 HOH A O   1 
HETATM 4475 O  O   . HOH G 6 .   ? 41.51700 -12.84200 11.08500 1.000 45.08141 ? 880 HOH A O   1 
HETATM 4476 O  O   . HOH G 6 .   ? 38.95100 -19.39500 50.43700 1.000 24.09956 ? 881 HOH A O   1 
HETATM 4477 O  O   . HOH G 6 .   ? 46.25000 -9.14200  35.19300 1.000 33.58538 ? 882 HOH A O   1 
HETATM 4478 O  O   . HOH G 6 .   ? 36.04400 -5.25100  23.01000 1.000 27.99800 ? 883 HOH A O   1 
HETATM 4479 O  O   . HOH G 6 .   ? 28.36600 11.18800  28.95600 1.000 33.83785 ? 884 HOH A O   1 
HETATM 4480 O  O   . HOH G 6 .   ? 18.19200 -1.10700  16.59100 1.000 43.20556 ? 885 HOH A O   1 
HETATM 4481 O  O   . HOH G 6 .   ? 27.82000 12.97900  6.18100  1.000 40.69997 ? 886 HOH A O   1 
HETATM 4482 O  O   . HOH G 6 .   ? 33.06200 -22.51200 55.66000 1.000 27.97635 ? 887 HOH A O   1 
HETATM 4483 O  O   . HOH G 6 .   ? 33.11000 -14.08500 54.72700 1.000 37.02176 ? 888 HOH A O   1 
HETATM 4484 O  O   . HOH G 6 .   ? 43.62300 -18.40100 9.25300  1.000 38.63266 ? 889 HOH A O   1 
HETATM 4485 O  O   . HOH G 6 .   ? 41.14600 -33.68100 58.10000 1.000 40.28462 ? 890 HOH A O   1 
HETATM 4486 O  O   . HOH G 6 .   ? 11.88100 -8.70300  26.68500 1.000 51.25785 ? 891 HOH A O   1 
HETATM 4487 O  O   . HOH G 6 .   ? 42.50300 -38.59300 53.50600 1.000 37.53313 ? 892 HOH A O   1 
HETATM 4488 O  O   . HOH G 6 .   ? 24.19100 -18.95400 30.98300 1.000 31.03918 ? 893 HOH A O   1 
HETATM 4489 O  O   . HOH G 6 .   ? 11.30300 -11.20500 20.24100 1.000 36.90778 ? 894 HOH A O   1 
HETATM 4490 O  O   . HOH G 6 .   ? 37.66500 13.13900  31.05100 1.000 44.30964 ? 895 HOH A O   1 
HETATM 4491 O  O   . HOH G 6 .   ? 31.60700 -2.61900  47.51800 1.000 39.26919 ? 896 HOH A O   1 
HETATM 4492 O  O   . HOH G 6 .   ? 15.96900 -19.16500 11.75700 1.000 48.38265 ? 897 HOH A O   1 
HETATM 4493 O  O   . HOH G 6 .   ? 25.93900 17.63300  19.10200 1.000 44.40841 ? 898 HOH A O   1 
HETATM 4494 O  O   . HOH G 6 .   ? 28.55800 -16.81700 54.03200 1.000 40.07675 ? 899 HOH A O   1 
HETATM 4495 O  O   . HOH G 6 .   ? 33.32500 8.81100   31.62500 1.000 37.68434 ? 900 HOH A O   1 
HETATM 4496 O  O   . HOH G 6 .   ? 10.95600 -16.89700 32.16500 1.000 31.56701 ? 901 HOH A O   1 
HETATM 4497 O  O   . HOH G 6 .   ? 11.68200 -13.76500 18.52600 1.000 46.02409 ? 902 HOH A O   1 
HETATM 4498 O  O   . HOH G 6 .   ? 29.70900 0.58300   2.09200  1.000 47.24041 ? 903 HOH A O   1 
HETATM 4499 O  O   . HOH G 6 .   ? 41.90300 -6.14900  25.16400 1.000 37.48075 ? 904 HOH A O   1 
HETATM 4500 O  O   . HOH G 6 .   ? 40.22600 16.60400  25.00800 1.000 42.35269 ? 905 HOH A O   1 
HETATM 4501 O  O   . HOH G 6 .   ? 14.463   -12.812   33.946   1.000 42.18053 ? 906 HOH A O   1 
HETATM 4502 O  O   . HOH G 6 .   ? 52.81000 -25.71900 28.44200 1.000 39.35710 ? 907 HOH A O   1 
HETATM 4503 O  O   . HOH G 6 .   ? 25.56300 14.51900  11.56400 1.000 32.63788 ? 908 HOH A O   1 
HETATM 4504 O  O   . HOH G 6 .   ? 50.24800 -28.95300 16.35100 1.000 48.18213 ? 909 HOH A O   1 
HETATM 4505 O  O   . HOH G 6 .   ? 24.71400 -32.13500 60.99700 1.000 36.87914 ? 910 HOH A O   1 
HETATM 4506 O  O   . HOH G 6 .   ? 68.58900 -4.26700  30.47800 1.000 52.79828 ? 911 HOH A O   1 
HETATM 4507 O  O   . HOH G 6 .   ? 26.16000 -13.57200 44.54200 1.000 32.56602 ? 912 HOH A O   1 
HETATM 4508 O  O   . HOH G 6 .   ? 41.73900 -9.62700  53.44800 1.000 37.58396 ? 913 HOH A O   1 
HETATM 4509 O  O   . HOH G 6 .   ? 9.56300  0.87500   21.30800 1.000 51.54383 ? 914 HOH A O   1 
HETATM 4510 O  O   . HOH G 6 .   ? 19.70700 2.42300   31.29600 1.000 52.42855 ? 915 HOH A O   1 
HETATM 4511 O  O   . HOH G 6 .   ? 18.73900 -35.59000 62.80800 1.000 54.60629 ? 916 HOH A O   1 
HETATM 4512 O  O   . HOH G 6 .   ? 61.43100 -20.16500 36.17200 1.000 54.44987 ? 917 HOH A O   1 
HETATM 4513 O  O   . HOH G 6 .   ? 55.70100 -2.13400  23.81000 1.000 57.72707 ? 918 HOH A O   1 
HETATM 4514 O  O   . HOH G 6 .   ? 30.73400 -37.74900 60.49300 1.000 35.97088 ? 919 HOH A O   1 
HETATM 4515 O  O   . HOH G 6 .   ? 33.32000 -13.89200 10.69100 1.000 40.31992 ? 920 HOH A O   1 
HETATM 4516 O  O   . HOH G 6 .   ? 18.67500 -4.62000  30.57500 1.000 47.50064 ? 921 HOH A O   1 
HETATM 4517 O  O   . HOH G 6 .   ? 62.39500 -27.53000 13.67200 1.000 60.89985 ? 922 HOH A O   1 
HETATM 4518 O  O   . HOH G 6 .   ? 37.14900 -3.06700  23.41900 1.000 33.32261 ? 923 HOH A O   1 
HETATM 4519 O  O   . HOH G 6 .   ? 46.91300 -40.09400 47.72600 1.000 44.53300 ? 924 HOH A O   1 
HETATM 4520 O  O   . HOH G 6 .   ? 28.45500 -2.73500  41.18000 1.000 30.35543 ? 925 HOH A O   1 
HETATM 4521 O  O   . HOH G 6 .   ? 49.04800 -20.35000 21.38600 1.000 45.90789 ? 926 HOH A O   1 
HETATM 4522 O  O   . HOH G 6 .   ? 53.48200 -18.52700 27.25700 1.000 48.90605 ? 927 HOH A O   1 
HETATM 4523 O  O   . HOH G 6 .   ? 44.86300 18.90700  21.22900 1.000 42.50223 ? 928 HOH A O   1 
HETATM 4524 O  O   . HOH G 6 .   ? 13.34000 -9.84300  27.90600 1.000 45.67848 ? 929 HOH A O   1 
HETATM 4525 O  O   . HOH G 6 .   ? 34.73300 12.62200  31.46400 1.000 47.83480 ? 930 HOH A O   1 
HETATM 4526 O  O   . HOH G 6 .   ? 41.43500 -41.24500 36.47900 1.000 44.79795 ? 931 HOH A O   1 
HETATM 4527 O  O   . HOH G 6 .   ? 51.658   -35.531   53.244   1.000 46.95462 ? 932 HOH A O   1 
HETATM 4528 O  O   . HOH G 6 .   ? 44.629   9.606     10.954   1.000 59.26400 ? 933 HOH A O   1 
HETATM 4529 O  O   . HOH G 6 .   ? 43.07800 6.91500   14.31600 1.000 50.06695 ? 934 HOH A O   1 
HETATM 4530 O  O   . HOH G 6 .   ? 29.25500 2.50100   35.64300 1.000 37.47000 ? 935 HOH A O   1 
HETATM 4531 O  O   . HOH G 6 .   ? 17.34700 -9.16500  32.99300 1.000 37.99229 ? 936 HOH A O   1 
HETATM 4532 O  O   . HOH G 6 .   ? 7.01700  -20.31000 22.00500 1.000 47.64655 ? 937 HOH A O   1 
HETATM 4533 O  O   . HOH G 6 .   ? 29.53400 16.30900  18.67700 1.000 44.34429 ? 938 HOH A O   1 
HETATM 4534 O  O   . HOH G 6 .   ? 30.21200 -40.45700 61.23900 1.000 39.04452 ? 939 HOH A O   1 
HETATM 4535 O  O   . HOH G 6 .   ? 25.02000 0.83500   34.24100 1.000 38.73798 ? 940 HOH A O   1 
HETATM 4536 O  O   . HOH G 6 .   ? 22.51700 1.79600   7.65700  1.000 41.62797 ? 941 HOH A O   1 
HETATM 4537 O  O   . HOH G 6 .   ? 10.21800 -15.87200 22.25700 1.000 43.60381 ? 942 HOH A O   1 
HETATM 4538 O  O   . HOH G 6 .   ? 27.97800 9.97500   32.90300 1.000 47.54888 ? 943 HOH A O   1 
HETATM 4539 O  O   . HOH G 6 .   ? 32.66900 10.06800  34.02400 1.000 47.08729 ? 944 HOH A O   1 
HETATM 4540 O  O   . HOH G 6 .   ? 19.77400 -37.49200 64.22700 1.000 38.15147 ? 945 HOH A O   1 
HETATM 4541 O  O   . HOH G 6 .   ? 21.01400 2.54400   33.68100 1.000 50.16897 ? 946 HOH A O   1 
HETATM 4542 O  O   . HOH G 6 .   ? 55.25100 -24.94800 42.64900 1.000 46.87952 ? 947 HOH A O   1 
HETATM 4543 O  O   . HOH G 6 .   ? 22.61800 13.18000  21.78000 1.000 37.15738 ? 948 HOH A O   1 
HETATM 4544 O  O   . HOH G 6 .   ? 33.10600 -43.02400 63.10600 1.000 45.34636 ? 949 HOH A O   1 
HETATM 4545 O  O   . HOH G 6 .   ? 30.52700 11.99200  30.29900 1.000 37.30848 ? 950 HOH A O   1 
HETATM 4546 O  O   . HOH G 6 .   ? 43.57800 -37.36200 30.99400 1.000 44.95146 ? 951 HOH A O   1 
HETATM 4547 O  O   . HOH G 6 .   ? 29.96300 -19.18900 56.53700 1.000 44.56472 ? 952 HOH A O   1 
HETATM 4548 O  O   . HOH G 6 .   ? 19.51200 -3.39900  16.78100 1.000 35.25216 ? 953 HOH A O   1 
HETATM 4549 O  O   . HOH G 6 .   ? 65.474   3.189     32.782   1.000 58.82251 ? 954 HOH A O   1 
HETATM 4550 O  O   . HOH G 6 .   ? 46.43600 -21.24800 21.93100 1.000 43.42269 ? 955 HOH A O   1 
HETATM 4551 O  O   . HOH G 6 .   ? 27.08200 0.44300   3.44600  1.000 45.68474 ? 956 HOH A O   1 
HETATM 4552 O  O   . HOH G 6 .   ? 46.49300 -39.14600 36.17000 1.000 47.45133 ? 957 HOH A O   1 
HETATM 4553 O  O   . HOH G 6 .   ? 20.30500 -2.51600  31.64200 1.000 40.12917 ? 958 HOH A O   1 
HETATM 4554 O  O   . HOH G 6 .   ? 34.70700 -6.84100  51.85400 1.000 32.41169 ? 959 HOH A O   1 
HETATM 4555 O  O   . HOH G 6 .   ? 33.27100 -4.47900  52.28300 1.000 41.86761 ? 960 HOH A O   1 
HETATM 4556 O  O   . HOH G 6 .   ? 39.74500 -33.98200 60.07200 1.000 39.27812 ? 961 HOH A O   1 
HETATM 4557 O  O   . HOH G 6 .   ? 21.03100 -1.18900  29.21900 1.000 27.34366 ? 962 HOH A O   1 
HETATM 4558 O  O   . HOH G 6 .   ? 20.66300 8.67100   25.66200 1.000 44.75929 ? 963 HOH A O   1 
HETATM 4559 O  O   . HOH G 6 .   ? 24.24900 11.11500  29.79700 1.000 45.54811 ? 964 HOH A O   1 
HETATM 4560 O  O   . HOH G 6 .   ? 42.694   11.427    11.714   1.000 47.60024 ? 965 HOH A O   1 
HETATM 4561 O  O   . HOH G 6 .   ? 40.53900 -33.09300 62.35100 1.000 43.06883 ? 966 HOH A O   1 
# 
