data_9JP2
# 
_entry.id   9JP2 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.398 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9JP2         pdb_00009jp2 10.2210/pdb9jp2/pdb 
WWPDB D_1300051876 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-11-27 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9JP2 
_pdbx_database_status.recvd_initial_deposition_date   2024-09-25 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              changyg@ouc.edu.cn 
_pdbx_contact_author.name_first         Yaoguang 
_pdbx_contact_author.name_last          Chang 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-8234-7272 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Chen, G.N.'  1 ? 
'Chang, Y.G.' 2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Complex structure of endo-1.3-fucanase with fucotetraose at 2.02 Angstroms resulution.' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Chen, G.N.'  1 ? 
primary 'Chang, Y.G.' 2 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer  man 'Glycoside-hydrolase family GH114 TIM-barrel domain-containing protein' 46766.727 1   ? ? ? ? 
2 branched syn 
;alpha-L-fucopyranose-(1-3)-2,4-di-O-sulfo-alpha-L-fucopyranose-(1-3)-2-O-sulfo-alpha-L-fucopyranose-(1-3)-2-O-sulfo-alpha-L-fucopyranose
;
922.833   1   ? ? ? ? 
3 water    nat water 18.015    270 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MGSSHHHHHHSSGLVPRGSHMASMTGGQQMGRGSEFLGQHYLNSDGSRFVPKDFYPKFSWDTTPMYYMFGDTTRLLEPEE
VEFIAERTDFLCIEKSHGRTPLGAAELGAKHEAAAFKKIKPDMKVLFYFNSAYAWPFTSYNQAFTRNKIDEHPKLKSFLI
VDPKTAELAHRRNVFFFDVLNPELREWWSTTVAKGVAESGCDGAFIDQMHGFAWLRADKSEDVQKAMGEMMALLKRKMGP
DKILLGNNANQDIAKDAFPVMDASMFEHYNEKLLSKESLLQDWDDMLRIAQAGKMSIFRIGVESDPRASQDQGRRGSRRD
QPVLAKERAEYYLACYLIGAQPYSYFQYGWGWTLSSGSLHEFPELRKALGPPKGAYDRTTPDGWEFTREFEHASVWVNTE
TGNAKITWR
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MGSSHHHHHHSSGLVPRGSHMASMTGGQQMGRGSEFLGQHYLNSDGSRFVPKDFYPKFSWDTTPMYYMFGDTTRLLEPEE
VEFIAERTDFLCIEKSHGRTPLGAAELGAKHEAAAFKKIKPDMKVLFYFNSAYAWPFTSYNQAFTRNKIDEHPKLKSFLI
VDPKTAELAHRRNVFFFDVLNPELREWWSTTVAKGVAESGCDGAFIDQMHGFAWLRADKSEDVQKAMGEMMALLKRKMGP
DKILLGNNANQDIAKDAFPVMDASMFEHYNEKLLSKESLLQDWDDMLRIAQAGKMSIFRIGVESDPRASQDQGRRGSRRD
QPVLAKERAEYYLACYLIGAQPYSYFQYGWGWTLSSGSLHEFPELRKALGPPKGAYDRTTPDGWEFTREFEHASVWVNTE
TGNAKITWR
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   3 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLY n 
1 3   SER n 
1 4   SER n 
1 5   HIS n 
1 6   HIS n 
1 7   HIS n 
1 8   HIS n 
1 9   HIS n 
1 10  HIS n 
1 11  SER n 
1 12  SER n 
1 13  GLY n 
1 14  LEU n 
1 15  VAL n 
1 16  PRO n 
1 17  ARG n 
1 18  GLY n 
1 19  SER n 
1 20  HIS n 
1 21  MET n 
1 22  ALA n 
1 23  SER n 
1 24  MET n 
1 25  THR n 
1 26  GLY n 
1 27  GLY n 
1 28  GLN n 
1 29  GLN n 
1 30  MET n 
1 31  GLY n 
1 32  ARG n 
1 33  GLY n 
1 34  SER n 
1 35  GLU n 
1 36  PHE n 
1 37  LEU n 
1 38  GLY n 
1 39  GLN n 
1 40  HIS n 
1 41  TYR n 
1 42  LEU n 
1 43  ASN n 
1 44  SER n 
1 45  ASP n 
1 46  GLY n 
1 47  SER n 
1 48  ARG n 
1 49  PHE n 
1 50  VAL n 
1 51  PRO n 
1 52  LYS n 
1 53  ASP n 
1 54  PHE n 
1 55  TYR n 
1 56  PRO n 
1 57  LYS n 
1 58  PHE n 
1 59  SER n 
1 60  TRP n 
1 61  ASP n 
1 62  THR n 
1 63  THR n 
1 64  PRO n 
1 65  MET n 
1 66  TYR n 
1 67  TYR n 
1 68  MET n 
1 69  PHE n 
1 70  GLY n 
1 71  ASP n 
1 72  THR n 
1 73  THR n 
1 74  ARG n 
1 75  LEU n 
1 76  LEU n 
1 77  GLU n 
1 78  PRO n 
1 79  GLU n 
1 80  GLU n 
1 81  VAL n 
1 82  GLU n 
1 83  PHE n 
1 84  ILE n 
1 85  ALA n 
1 86  GLU n 
1 87  ARG n 
1 88  THR n 
1 89  ASP n 
1 90  PHE n 
1 91  LEU n 
1 92  CYS n 
1 93  ILE n 
1 94  GLU n 
1 95  LYS n 
1 96  SER n 
1 97  HIS n 
1 98  GLY n 
1 99  ARG n 
1 100 THR n 
1 101 PRO n 
1 102 LEU n 
1 103 GLY n 
1 104 ALA n 
1 105 ALA n 
1 106 GLU n 
1 107 LEU n 
1 108 GLY n 
1 109 ALA n 
1 110 LYS n 
1 111 HIS n 
1 112 GLU n 
1 113 ALA n 
1 114 ALA n 
1 115 ALA n 
1 116 PHE n 
1 117 LYS n 
1 118 LYS n 
1 119 ILE n 
1 120 LYS n 
1 121 PRO n 
1 122 ASP n 
1 123 MET n 
1 124 LYS n 
1 125 VAL n 
1 126 LEU n 
1 127 PHE n 
1 128 TYR n 
1 129 PHE n 
1 130 ASN n 
1 131 SER n 
1 132 ALA n 
1 133 TYR n 
1 134 ALA n 
1 135 TRP n 
1 136 PRO n 
1 137 PHE n 
1 138 THR n 
1 139 SER n 
1 140 TYR n 
1 141 ASN n 
1 142 GLN n 
1 143 ALA n 
1 144 PHE n 
1 145 THR n 
1 146 ARG n 
1 147 ASN n 
1 148 LYS n 
1 149 ILE n 
1 150 ASP n 
1 151 GLU n 
1 152 HIS n 
1 153 PRO n 
1 154 LYS n 
1 155 LEU n 
1 156 LYS n 
1 157 SER n 
1 158 PHE n 
1 159 LEU n 
1 160 ILE n 
1 161 VAL n 
1 162 ASP n 
1 163 PRO n 
1 164 LYS n 
1 165 THR n 
1 166 ALA n 
1 167 GLU n 
1 168 LEU n 
1 169 ALA n 
1 170 HIS n 
1 171 ARG n 
1 172 ARG n 
1 173 ASN n 
1 174 VAL n 
1 175 PHE n 
1 176 PHE n 
1 177 PHE n 
1 178 ASP n 
1 179 VAL n 
1 180 LEU n 
1 181 ASN n 
1 182 PRO n 
1 183 GLU n 
1 184 LEU n 
1 185 ARG n 
1 186 GLU n 
1 187 TRP n 
1 188 TRP n 
1 189 SER n 
1 190 THR n 
1 191 THR n 
1 192 VAL n 
1 193 ALA n 
1 194 LYS n 
1 195 GLY n 
1 196 VAL n 
1 197 ALA n 
1 198 GLU n 
1 199 SER n 
1 200 GLY n 
1 201 CYS n 
1 202 ASP n 
1 203 GLY n 
1 204 ALA n 
1 205 PHE n 
1 206 ILE n 
1 207 ASP n 
1 208 GLN n 
1 209 MET n 
1 210 HIS n 
1 211 GLY n 
1 212 PHE n 
1 213 ALA n 
1 214 TRP n 
1 215 LEU n 
1 216 ARG n 
1 217 ALA n 
1 218 ASP n 
1 219 LYS n 
1 220 SER n 
1 221 GLU n 
1 222 ASP n 
1 223 VAL n 
1 224 GLN n 
1 225 LYS n 
1 226 ALA n 
1 227 MET n 
1 228 GLY n 
1 229 GLU n 
1 230 MET n 
1 231 MET n 
1 232 ALA n 
1 233 LEU n 
1 234 LEU n 
1 235 LYS n 
1 236 ARG n 
1 237 LYS n 
1 238 MET n 
1 239 GLY n 
1 240 PRO n 
1 241 ASP n 
1 242 LYS n 
1 243 ILE n 
1 244 LEU n 
1 245 LEU n 
1 246 GLY n 
1 247 ASN n 
1 248 ASN n 
1 249 ALA n 
1 250 ASN n 
1 251 GLN n 
1 252 ASP n 
1 253 ILE n 
1 254 ALA n 
1 255 LYS n 
1 256 ASP n 
1 257 ALA n 
1 258 PHE n 
1 259 PRO n 
1 260 VAL n 
1 261 MET n 
1 262 ASP n 
1 263 ALA n 
1 264 SER n 
1 265 MET n 
1 266 PHE n 
1 267 GLU n 
1 268 HIS n 
1 269 TYR n 
1 270 ASN n 
1 271 GLU n 
1 272 LYS n 
1 273 LEU n 
1 274 LEU n 
1 275 SER n 
1 276 LYS n 
1 277 GLU n 
1 278 SER n 
1 279 LEU n 
1 280 LEU n 
1 281 GLN n 
1 282 ASP n 
1 283 TRP n 
1 284 ASP n 
1 285 ASP n 
1 286 MET n 
1 287 LEU n 
1 288 ARG n 
1 289 ILE n 
1 290 ALA n 
1 291 GLN n 
1 292 ALA n 
1 293 GLY n 
1 294 LYS n 
1 295 MET n 
1 296 SER n 
1 297 ILE n 
1 298 PHE n 
1 299 ARG n 
1 300 ILE n 
1 301 GLY n 
1 302 VAL n 
1 303 GLU n 
1 304 SER n 
1 305 ASP n 
1 306 PRO n 
1 307 ARG n 
1 308 ALA n 
1 309 SER n 
1 310 GLN n 
1 311 ASP n 
1 312 GLN n 
1 313 GLY n 
1 314 ARG n 
1 315 ARG n 
1 316 GLY n 
1 317 SER n 
1 318 ARG n 
1 319 ARG n 
1 320 ASP n 
1 321 GLN n 
1 322 PRO n 
1 323 VAL n 
1 324 LEU n 
1 325 ALA n 
1 326 LYS n 
1 327 GLU n 
1 328 ARG n 
1 329 ALA n 
1 330 GLU n 
1 331 TYR n 
1 332 TYR n 
1 333 LEU n 
1 334 ALA n 
1 335 CYS n 
1 336 TYR n 
1 337 LEU n 
1 338 ILE n 
1 339 GLY n 
1 340 ALA n 
1 341 GLN n 
1 342 PRO n 
1 343 TYR n 
1 344 SER n 
1 345 TYR n 
1 346 PHE n 
1 347 GLN n 
1 348 TYR n 
1 349 GLY n 
1 350 TRP n 
1 351 GLY n 
1 352 TRP n 
1 353 THR n 
1 354 LEU n 
1 355 SER n 
1 356 SER n 
1 357 GLY n 
1 358 SER n 
1 359 LEU n 
1 360 HIS n 
1 361 GLU n 
1 362 PHE n 
1 363 PRO n 
1 364 GLU n 
1 365 LEU n 
1 366 ARG n 
1 367 LYS n 
1 368 ALA n 
1 369 LEU n 
1 370 GLY n 
1 371 PRO n 
1 372 PRO n 
1 373 LYS n 
1 374 GLY n 
1 375 ALA n 
1 376 TYR n 
1 377 ASP n 
1 378 ARG n 
1 379 THR n 
1 380 THR n 
1 381 PRO n 
1 382 ASP n 
1 383 GLY n 
1 384 TRP n 
1 385 GLU n 
1 386 PHE n 
1 387 THR n 
1 388 ARG n 
1 389 GLU n 
1 390 PHE n 
1 391 GLU n 
1 392 HIS n 
1 393 ALA n 
1 394 SER n 
1 395 VAL n 
1 396 TRP n 
1 397 VAL n 
1 398 ASN n 
1 399 THR n 
1 400 GLU n 
1 401 THR n 
1 402 GLY n 
1 403 ASN n 
1 404 ALA n 
1 405 LYS n 
1 406 ILE n 
1 407 THR n 
1 408 TRP n 
1 409 ARG n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   409 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 Poly41_55130 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Novipirellula artificiosorum' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2528016 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
_pdbx_entity_branch.entity_id   2 
_pdbx_entity_branch.type        oligosaccharide 
# 
_pdbx_entity_branch_descriptor.ordinal           1 
_pdbx_entity_branch_descriptor.entity_id         2 
_pdbx_entity_branch_descriptor.descriptor        
'[][a-L-Fucp2SO3]{[(3+1)][a-L-Fucp2SO3]{[(3+1)][a-L-Fucp2SO34SO3]{[(3+1)][a-L-Fucp]{}}}}' 
_pdbx_entity_branch_descriptor.type              LINUCS 
_pdbx_entity_branch_descriptor.program           PDB-CARE 
_pdbx_entity_branch_descriptor.program_version   ? 
# 
loop_
_pdbx_entity_branch_link.link_id 
_pdbx_entity_branch_link.entity_id 
_pdbx_entity_branch_link.entity_branch_list_num_1 
_pdbx_entity_branch_link.comp_id_1 
_pdbx_entity_branch_link.atom_id_1 
_pdbx_entity_branch_link.leaving_atom_id_1 
_pdbx_entity_branch_link.entity_branch_list_num_2 
_pdbx_entity_branch_link.comp_id_2 
_pdbx_entity_branch_link.atom_id_2 
_pdbx_entity_branch_link.leaving_atom_id_2 
_pdbx_entity_branch_link.value_order 
_pdbx_entity_branch_link.details 
1 2 2 X6Y C1 H1 1 X6Y O3 HO3 sing ? 
2 2 3 X2Y C1 O1 2 X6Y O3 HO3 sing ? 
3 2 4 FUC C1 O1 3 X2Y O3 HO3 sing ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking'           y ALANINE                             ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking'           y ARGININE                            ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking'           y ASPARAGINE                          ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking'           y 'ASPARTIC ACID'                     ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking'           y CYSTEINE                            ? 'C3 H7 N O2 S'   121.158 
FUC 'L-saccharide, alpha linking' . alpha-L-fucopyranose                
'alpha-L-fucose; 6-deoxy-alpha-L-galactopyranose; L-fucose; fucose' 'C6 H12 O5'      164.156 
GLN 'L-peptide linking'           y GLUTAMINE                           ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking'           y 'GLUTAMIC ACID'                     ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'             y GLYCINE                             ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking'           y HISTIDINE                           ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer                   . WATER                               ? 'H2 O'           18.015  
ILE 'L-peptide linking'           y ISOLEUCINE                          ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking'           y LEUCINE                             ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking'           y LYSINE                              ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking'           y METHIONINE                          ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking'           y PHENYLALANINE                       ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking'           y PROLINE                             ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking'           y SERINE                              ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking'           y THREONINE                           ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking'           y TRYPTOPHAN                          ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking'           y TYROSINE                            ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking'           y VALINE                              ? 'C5 H11 N O2'    117.146 
X2Y 'L-saccharide, alpha linking' n 2,4-di-O-sulfo-alpha-L-fucopyranose 6-deoxy-2,4-di-O-sulfo-alpha-L-galactopyranose 
'C6 H12 O11 S2'  324.283 
X6Y 'L-saccharide, alpha linking' n 2-O-sulfo-alpha-L-fucopyranose      6-deoxy-2-O-sulfo-alpha-L-galactopyranose 'C6 H12 O8 S'    
244.220 
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
FUC 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 LFucpa           
FUC 'COMMON NAME'                         GMML     1.0 a-L-fucopyranose 
FUC 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 a-L-Fucp         
FUC 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 Fuc              
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -35 ?   ?   ?   A . n 
A 1 2   GLY 2   -34 ?   ?   ?   A . n 
A 1 3   SER 3   -33 ?   ?   ?   A . n 
A 1 4   SER 4   -32 ?   ?   ?   A . n 
A 1 5   HIS 5   -31 ?   ?   ?   A . n 
A 1 6   HIS 6   -30 ?   ?   ?   A . n 
A 1 7   HIS 7   -29 ?   ?   ?   A . n 
A 1 8   HIS 8   -28 ?   ?   ?   A . n 
A 1 9   HIS 9   -27 ?   ?   ?   A . n 
A 1 10  HIS 10  -26 ?   ?   ?   A . n 
A 1 11  SER 11  -25 ?   ?   ?   A . n 
A 1 12  SER 12  -24 ?   ?   ?   A . n 
A 1 13  GLY 13  -23 ?   ?   ?   A . n 
A 1 14  LEU 14  -22 ?   ?   ?   A . n 
A 1 15  VAL 15  -21 ?   ?   ?   A . n 
A 1 16  PRO 16  -20 ?   ?   ?   A . n 
A 1 17  ARG 17  -19 ?   ?   ?   A . n 
A 1 18  GLY 18  -18 ?   ?   ?   A . n 
A 1 19  SER 19  -17 ?   ?   ?   A . n 
A 1 20  HIS 20  -16 ?   ?   ?   A . n 
A 1 21  MET 21  -15 ?   ?   ?   A . n 
A 1 22  ALA 22  -14 ?   ?   ?   A . n 
A 1 23  SER 23  -13 ?   ?   ?   A . n 
A 1 24  MET 24  -12 ?   ?   ?   A . n 
A 1 25  THR 25  -11 ?   ?   ?   A . n 
A 1 26  GLY 26  -10 ?   ?   ?   A . n 
A 1 27  GLY 27  -9  ?   ?   ?   A . n 
A 1 28  GLN 28  -8  ?   ?   ?   A . n 
A 1 29  GLN 29  -7  ?   ?   ?   A . n 
A 1 30  MET 30  -6  ?   ?   ?   A . n 
A 1 31  GLY 31  -5  ?   ?   ?   A . n 
A 1 32  ARG 32  -4  ?   ?   ?   A . n 
A 1 33  GLY 33  -3  ?   ?   ?   A . n 
A 1 34  SER 34  -2  ?   ?   ?   A . n 
A 1 35  GLU 35  -1  ?   ?   ?   A . n 
A 1 36  PHE 36  0   ?   ?   ?   A . n 
A 1 37  LEU 37  1   ?   ?   ?   A . n 
A 1 38  GLY 38  2   ?   ?   ?   A . n 
A 1 39  GLN 39  3   ?   ?   ?   A . n 
A 1 40  HIS 40  4   4   HIS HIS A . n 
A 1 41  TYR 41  5   5   TYR TYR A . n 
A 1 42  LEU 42  6   6   LEU LEU A . n 
A 1 43  ASN 43  7   7   ASN ASN A . n 
A 1 44  SER 44  8   8   SER SER A . n 
A 1 45  ASP 45  9   9   ASP ASP A . n 
A 1 46  GLY 46  10  10  GLY GLY A . n 
A 1 47  SER 47  11  11  SER SER A . n 
A 1 48  ARG 48  12  12  ARG ARG A . n 
A 1 49  PHE 49  13  13  PHE PHE A . n 
A 1 50  VAL 50  14  14  VAL VAL A . n 
A 1 51  PRO 51  15  15  PRO PRO A . n 
A 1 52  LYS 52  16  16  LYS LYS A . n 
A 1 53  ASP 53  17  17  ASP ASP A . n 
A 1 54  PHE 54  18  18  PHE PHE A . n 
A 1 55  TYR 55  19  19  TYR TYR A . n 
A 1 56  PRO 56  20  20  PRO PRO A . n 
A 1 57  LYS 57  21  21  LYS LYS A . n 
A 1 58  PHE 58  22  22  PHE PHE A . n 
A 1 59  SER 59  23  23  SER SER A . n 
A 1 60  TRP 60  24  24  TRP TRP A . n 
A 1 61  ASP 61  25  25  ASP ASP A . n 
A 1 62  THR 62  26  26  THR THR A . n 
A 1 63  THR 63  27  27  THR THR A . n 
A 1 64  PRO 64  28  28  PRO PRO A . n 
A 1 65  MET 65  29  29  MET MET A . n 
A 1 66  TYR 66  30  30  TYR TYR A . n 
A 1 67  TYR 67  31  31  TYR TYR A . n 
A 1 68  MET 68  32  32  MET MET A . n 
A 1 69  PHE 69  33  33  PHE PHE A . n 
A 1 70  GLY 70  34  34  GLY GLY A . n 
A 1 71  ASP 71  35  35  ASP ASP A . n 
A 1 72  THR 72  36  36  THR THR A . n 
A 1 73  THR 73  37  37  THR THR A . n 
A 1 74  ARG 74  38  38  ARG ARG A . n 
A 1 75  LEU 75  39  39  LEU LEU A . n 
A 1 76  LEU 76  40  40  LEU LEU A . n 
A 1 77  GLU 77  41  41  GLU GLU A . n 
A 1 78  PRO 78  42  42  PRO PRO A . n 
A 1 79  GLU 79  43  43  GLU GLU A . n 
A 1 80  GLU 80  44  44  GLU GLU A . n 
A 1 81  VAL 81  45  45  VAL VAL A . n 
A 1 82  GLU 82  46  46  GLU GLU A . n 
A 1 83  PHE 83  47  47  PHE PHE A . n 
A 1 84  ILE 84  48  48  ILE ILE A . n 
A 1 85  ALA 85  49  49  ALA ALA A . n 
A 1 86  GLU 86  50  50  GLU GLU A . n 
A 1 87  ARG 87  51  51  ARG ARG A . n 
A 1 88  THR 88  52  52  THR THR A . n 
A 1 89  ASP 89  53  53  ASP ASP A . n 
A 1 90  PHE 90  54  54  PHE PHE A . n 
A 1 91  LEU 91  55  55  LEU LEU A . n 
A 1 92  CYS 92  56  56  CYS CYS A . n 
A 1 93  ILE 93  57  57  ILE ILE A . n 
A 1 94  GLU 94  58  58  GLU GLU A . n 
A 1 95  LYS 95  59  59  LYS LYS A . n 
A 1 96  SER 96  60  60  SER SER A . n 
A 1 97  HIS 97  61  61  HIS HIS A . n 
A 1 98  GLY 98  62  62  GLY GLY A . n 
A 1 99  ARG 99  63  63  ARG ARG A . n 
A 1 100 THR 100 64  64  THR THR A . n 
A 1 101 PRO 101 65  65  PRO PRO A . n 
A 1 102 LEU 102 66  66  LEU LEU A . n 
A 1 103 GLY 103 67  67  GLY GLY A . n 
A 1 104 ALA 104 68  68  ALA ALA A . n 
A 1 105 ALA 105 69  69  ALA ALA A . n 
A 1 106 GLU 106 70  70  GLU GLU A . n 
A 1 107 LEU 107 71  71  LEU LEU A . n 
A 1 108 GLY 108 72  72  GLY GLY A . n 
A 1 109 ALA 109 73  73  ALA ALA A . n 
A 1 110 LYS 110 74  74  LYS LYS A . n 
A 1 111 HIS 111 75  75  HIS HIS A . n 
A 1 112 GLU 112 76  76  GLU GLU A . n 
A 1 113 ALA 113 77  77  ALA ALA A . n 
A 1 114 ALA 114 78  78  ALA ALA A . n 
A 1 115 ALA 115 79  79  ALA ALA A . n 
A 1 116 PHE 116 80  80  PHE PHE A . n 
A 1 117 LYS 117 81  81  LYS LYS A . n 
A 1 118 LYS 118 82  82  LYS LYS A . n 
A 1 119 ILE 119 83  83  ILE ILE A . n 
A 1 120 LYS 120 84  84  LYS LYS A . n 
A 1 121 PRO 121 85  85  PRO PRO A . n 
A 1 122 ASP 122 86  86  ASP ASP A . n 
A 1 123 MET 123 87  87  MET MET A . n 
A 1 124 LYS 124 88  88  LYS LYS A . n 
A 1 125 VAL 125 89  89  VAL VAL A . n 
A 1 126 LEU 126 90  90  LEU LEU A . n 
A 1 127 PHE 127 91  91  PHE PHE A . n 
A 1 128 TYR 128 92  92  TYR TYR A . n 
A 1 129 PHE 129 93  93  PHE PHE A . n 
A 1 130 ASN 130 94  94  ASN ASN A . n 
A 1 131 SER 131 95  95  SER SER A . n 
A 1 132 ALA 132 96  96  ALA ALA A . n 
A 1 133 TYR 133 97  97  TYR TYR A . n 
A 1 134 ALA 134 98  98  ALA ALA A . n 
A 1 135 TRP 135 99  99  TRP TRP A . n 
A 1 136 PRO 136 100 100 PRO PRO A . n 
A 1 137 PHE 137 101 101 PHE PHE A . n 
A 1 138 THR 138 102 102 THR THR A . n 
A 1 139 SER 139 103 103 SER SER A . n 
A 1 140 TYR 140 104 104 TYR TYR A . n 
A 1 141 ASN 141 105 105 ASN ASN A . n 
A 1 142 GLN 142 106 106 GLN GLN A . n 
A 1 143 ALA 143 107 107 ALA ALA A . n 
A 1 144 PHE 144 108 108 PHE PHE A . n 
A 1 145 THR 145 109 109 THR THR A . n 
A 1 146 ARG 146 110 110 ARG ARG A . n 
A 1 147 ASN 147 111 111 ASN ASN A . n 
A 1 148 LYS 148 112 112 LYS LYS A . n 
A 1 149 ILE 149 113 113 ILE ILE A . n 
A 1 150 ASP 150 114 114 ASP ASP A . n 
A 1 151 GLU 151 115 115 GLU GLU A . n 
A 1 152 HIS 152 116 116 HIS HIS A . n 
A 1 153 PRO 153 117 117 PRO PRO A . n 
A 1 154 LYS 154 118 118 LYS LYS A . n 
A 1 155 LEU 155 119 119 LEU LEU A . n 
A 1 156 LYS 156 120 120 LYS LYS A . n 
A 1 157 SER 157 121 121 SER SER A . n 
A 1 158 PHE 158 122 122 PHE PHE A . n 
A 1 159 LEU 159 123 123 LEU LEU A . n 
A 1 160 ILE 160 124 124 ILE ILE A . n 
A 1 161 VAL 161 125 125 VAL VAL A . n 
A 1 162 ASP 162 126 126 ASP ASP A . n 
A 1 163 PRO 163 127 127 PRO PRO A . n 
A 1 164 LYS 164 128 128 LYS LYS A . n 
A 1 165 THR 165 129 129 THR THR A . n 
A 1 166 ALA 166 130 130 ALA ALA A . n 
A 1 167 GLU 167 131 131 GLU GLU A . n 
A 1 168 LEU 168 132 132 LEU LEU A . n 
A 1 169 ALA 169 133 133 ALA ALA A . n 
A 1 170 HIS 170 134 134 HIS HIS A . n 
A 1 171 ARG 171 135 135 ARG ARG A . n 
A 1 172 ARG 172 136 136 ARG ARG A . n 
A 1 173 ASN 173 137 137 ASN ASN A . n 
A 1 174 VAL 174 138 138 VAL VAL A . n 
A 1 175 PHE 175 139 139 PHE PHE A . n 
A 1 176 PHE 176 140 140 PHE PHE A . n 
A 1 177 PHE 177 141 141 PHE PHE A . n 
A 1 178 ASP 178 142 142 ASP ASP A . n 
A 1 179 VAL 179 143 143 VAL VAL A . n 
A 1 180 LEU 180 144 144 LEU LEU A . n 
A 1 181 ASN 181 145 145 ASN ASN A . n 
A 1 182 PRO 182 146 146 PRO PRO A . n 
A 1 183 GLU 183 147 147 GLU GLU A . n 
A 1 184 LEU 184 148 148 LEU LEU A . n 
A 1 185 ARG 185 149 149 ARG ARG A . n 
A 1 186 GLU 186 150 150 GLU GLU A . n 
A 1 187 TRP 187 151 151 TRP TRP A . n 
A 1 188 TRP 188 152 152 TRP TRP A . n 
A 1 189 SER 189 153 153 SER SER A . n 
A 1 190 THR 190 154 154 THR THR A . n 
A 1 191 THR 191 155 155 THR THR A . n 
A 1 192 VAL 192 156 156 VAL VAL A . n 
A 1 193 ALA 193 157 157 ALA ALA A . n 
A 1 194 LYS 194 158 158 LYS LYS A . n 
A 1 195 GLY 195 159 159 GLY GLY A . n 
A 1 196 VAL 196 160 160 VAL VAL A . n 
A 1 197 ALA 197 161 161 ALA ALA A . n 
A 1 198 GLU 198 162 162 GLU GLU A . n 
A 1 199 SER 199 163 163 SER SER A . n 
A 1 200 GLY 200 164 164 GLY GLY A . n 
A 1 201 CYS 201 165 165 CYS CYS A . n 
A 1 202 ASP 202 166 166 ASP ASP A . n 
A 1 203 GLY 203 167 167 GLY GLY A . n 
A 1 204 ALA 204 168 168 ALA ALA A . n 
A 1 205 PHE 205 169 169 PHE PHE A . n 
A 1 206 ILE 206 170 170 ILE ILE A . n 
A 1 207 ASP 207 171 171 ASP ASP A . n 
A 1 208 GLN 208 172 172 GLN GLN A . n 
A 1 209 MET 209 173 173 MET MET A . n 
A 1 210 HIS 210 174 174 HIS HIS A . n 
A 1 211 GLY 211 175 175 GLY GLY A . n 
A 1 212 PHE 212 176 176 PHE PHE A . n 
A 1 213 ALA 213 177 177 ALA ALA A . n 
A 1 214 TRP 214 178 178 TRP TRP A . n 
A 1 215 LEU 215 179 179 LEU LEU A . n 
A 1 216 ARG 216 180 180 ARG ARG A . n 
A 1 217 ALA 217 181 181 ALA ALA A . n 
A 1 218 ASP 218 182 182 ASP ASP A . n 
A 1 219 LYS 219 183 183 LYS LYS A . n 
A 1 220 SER 220 184 184 SER SER A . n 
A 1 221 GLU 221 185 185 GLU GLU A . n 
A 1 222 ASP 222 186 186 ASP ASP A . n 
A 1 223 VAL 223 187 187 VAL VAL A . n 
A 1 224 GLN 224 188 188 GLN GLN A . n 
A 1 225 LYS 225 189 189 LYS LYS A . n 
A 1 226 ALA 226 190 190 ALA ALA A . n 
A 1 227 MET 227 191 191 MET MET A . n 
A 1 228 GLY 228 192 192 GLY GLY A . n 
A 1 229 GLU 229 193 193 GLU GLU A . n 
A 1 230 MET 230 194 194 MET MET A . n 
A 1 231 MET 231 195 195 MET MET A . n 
A 1 232 ALA 232 196 196 ALA ALA A . n 
A 1 233 LEU 233 197 197 LEU LEU A . n 
A 1 234 LEU 234 198 198 LEU LEU A . n 
A 1 235 LYS 235 199 199 LYS LYS A . n 
A 1 236 ARG 236 200 200 ARG ARG A . n 
A 1 237 LYS 237 201 201 LYS LYS A . n 
A 1 238 MET 238 202 202 MET MET A . n 
A 1 239 GLY 239 203 203 GLY GLY A . n 
A 1 240 PRO 240 204 204 PRO PRO A . n 
A 1 241 ASP 241 205 205 ASP ASP A . n 
A 1 242 LYS 242 206 206 LYS LYS A . n 
A 1 243 ILE 243 207 207 ILE ILE A . n 
A 1 244 LEU 244 208 208 LEU LEU A . n 
A 1 245 LEU 245 209 209 LEU LEU A . n 
A 1 246 GLY 246 210 210 GLY GLY A . n 
A 1 247 ASN 247 211 211 ASN ASN A . n 
A 1 248 ASN 248 212 212 ASN ASN A . n 
A 1 249 ALA 249 213 213 ALA ALA A . n 
A 1 250 ASN 250 214 214 ASN ASN A . n 
A 1 251 GLN 251 215 215 GLN GLN A . n 
A 1 252 ASP 252 216 216 ASP ASP A . n 
A 1 253 ILE 253 217 217 ILE ILE A . n 
A 1 254 ALA 254 218 218 ALA ALA A . n 
A 1 255 LYS 255 219 219 LYS LYS A . n 
A 1 256 ASP 256 220 220 ASP ASP A . n 
A 1 257 ALA 257 221 221 ALA ALA A . n 
A 1 258 PHE 258 222 222 PHE PHE A . n 
A 1 259 PRO 259 223 223 PRO PRO A . n 
A 1 260 VAL 260 224 224 VAL VAL A . n 
A 1 261 MET 261 225 225 MET MET A . n 
A 1 262 ASP 262 226 226 ASP ASP A . n 
A 1 263 ALA 263 227 227 ALA ALA A . n 
A 1 264 SER 264 228 228 SER SER A . n 
A 1 265 MET 265 229 229 MET MET A . n 
A 1 266 PHE 266 230 230 PHE PHE A . n 
A 1 267 GLU 267 231 231 GLU GLU A . n 
A 1 268 HIS 268 232 232 HIS HIS A . n 
A 1 269 TYR 269 233 233 TYR TYR A . n 
A 1 270 ASN 270 234 234 ASN ASN A . n 
A 1 271 GLU 271 235 235 GLU GLU A . n 
A 1 272 LYS 272 236 236 LYS LYS A . n 
A 1 273 LEU 273 237 237 LEU LEU A . n 
A 1 274 LEU 274 238 238 LEU LEU A . n 
A 1 275 SER 275 239 239 SER SER A . n 
A 1 276 LYS 276 240 240 LYS LYS A . n 
A 1 277 GLU 277 241 241 GLU GLU A . n 
A 1 278 SER 278 242 242 SER SER A . n 
A 1 279 LEU 279 243 243 LEU LEU A . n 
A 1 280 LEU 280 244 244 LEU LEU A . n 
A 1 281 GLN 281 245 245 GLN GLN A . n 
A 1 282 ASP 282 246 246 ASP ASP A . n 
A 1 283 TRP 283 247 247 TRP TRP A . n 
A 1 284 ASP 284 248 248 ASP ASP A . n 
A 1 285 ASP 285 249 249 ASP ASP A . n 
A 1 286 MET 286 250 250 MET MET A . n 
A 1 287 LEU 287 251 251 LEU LEU A . n 
A 1 288 ARG 288 252 252 ARG ARG A . n 
A 1 289 ILE 289 253 253 ILE ILE A . n 
A 1 290 ALA 290 254 254 ALA ALA A . n 
A 1 291 GLN 291 255 255 GLN GLN A . n 
A 1 292 ALA 292 256 256 ALA ALA A . n 
A 1 293 GLY 293 257 257 GLY GLY A . n 
A 1 294 LYS 294 258 258 LYS LYS A . n 
A 1 295 MET 295 259 259 MET MET A . n 
A 1 296 SER 296 260 260 SER SER A . n 
A 1 297 ILE 297 261 261 ILE ILE A . n 
A 1 298 PHE 298 262 262 PHE PHE A . n 
A 1 299 ARG 299 263 263 ARG ARG A . n 
A 1 300 ILE 300 264 264 ILE ILE A . n 
A 1 301 GLY 301 265 265 GLY GLY A . n 
A 1 302 VAL 302 266 266 VAL VAL A . n 
A 1 303 GLU 303 267 267 GLU GLU A . n 
A 1 304 SER 304 268 268 SER SER A . n 
A 1 305 ASP 305 269 269 ASP ASP A . n 
A 1 306 PRO 306 270 ?   ?   ?   A . n 
A 1 307 ARG 307 271 ?   ?   ?   A . n 
A 1 308 ALA 308 272 ?   ?   ?   A . n 
A 1 309 SER 309 273 ?   ?   ?   A . n 
A 1 310 GLN 310 274 ?   ?   ?   A . n 
A 1 311 ASP 311 275 ?   ?   ?   A . n 
A 1 312 GLN 312 276 ?   ?   ?   A . n 
A 1 313 GLY 313 277 ?   ?   ?   A . n 
A 1 314 ARG 314 278 ?   ?   ?   A . n 
A 1 315 ARG 315 279 ?   ?   ?   A . n 
A 1 316 GLY 316 280 ?   ?   ?   A . n 
A 1 317 SER 317 281 ?   ?   ?   A . n 
A 1 318 ARG 318 282 ?   ?   ?   A . n 
A 1 319 ARG 319 283 ?   ?   ?   A . n 
A 1 320 ASP 320 284 ?   ?   ?   A . n 
A 1 321 GLN 321 285 285 GLN GLN A . n 
A 1 322 PRO 322 286 286 PRO PRO A . n 
A 1 323 VAL 323 287 287 VAL VAL A . n 
A 1 324 LEU 324 288 288 LEU LEU A . n 
A 1 325 ALA 325 289 289 ALA ALA A . n 
A 1 326 LYS 326 290 290 LYS LYS A . n 
A 1 327 GLU 327 291 291 GLU GLU A . n 
A 1 328 ARG 328 292 292 ARG ARG A . n 
A 1 329 ALA 329 293 293 ALA ALA A . n 
A 1 330 GLU 330 294 294 GLU GLU A . n 
A 1 331 TYR 331 295 295 TYR TYR A . n 
A 1 332 TYR 332 296 296 TYR TYR A . n 
A 1 333 LEU 333 297 297 LEU LEU A . n 
A 1 334 ALA 334 298 298 ALA ALA A . n 
A 1 335 CYS 335 299 299 CYS CYS A . n 
A 1 336 TYR 336 300 300 TYR TYR A . n 
A 1 337 LEU 337 301 301 LEU LEU A . n 
A 1 338 ILE 338 302 302 ILE ILE A . n 
A 1 339 GLY 339 303 303 GLY GLY A . n 
A 1 340 ALA 340 304 304 ALA ALA A . n 
A 1 341 GLN 341 305 305 GLN GLN A . n 
A 1 342 PRO 342 306 306 PRO PRO A . n 
A 1 343 TYR 343 307 307 TYR TYR A . n 
A 1 344 SER 344 308 308 SER SER A . n 
A 1 345 TYR 345 309 309 TYR TYR A . n 
A 1 346 PHE 346 310 310 PHE PHE A . n 
A 1 347 GLN 347 311 311 GLN GLN A . n 
A 1 348 TYR 348 312 312 TYR TYR A . n 
A 1 349 GLY 349 313 313 GLY GLY A . n 
A 1 350 TRP 350 314 314 TRP TRP A . n 
A 1 351 GLY 351 315 315 GLY GLY A . n 
A 1 352 TRP 352 316 316 TRP TRP A . n 
A 1 353 THR 353 317 317 THR THR A . n 
A 1 354 LEU 354 318 318 LEU LEU A . n 
A 1 355 SER 355 319 319 SER SER A . n 
A 1 356 SER 356 320 320 SER SER A . n 
A 1 357 GLY 357 321 321 GLY GLY A . n 
A 1 358 SER 358 322 322 SER SER A . n 
A 1 359 LEU 359 323 323 LEU LEU A . n 
A 1 360 HIS 360 324 324 HIS HIS A . n 
A 1 361 GLU 361 325 325 GLU GLU A . n 
A 1 362 PHE 362 326 326 PHE PHE A . n 
A 1 363 PRO 363 327 327 PRO PRO A . n 
A 1 364 GLU 364 328 328 GLU GLU A . n 
A 1 365 LEU 365 329 329 LEU LEU A . n 
A 1 366 ARG 366 330 330 ARG ARG A . n 
A 1 367 LYS 367 331 331 LYS LYS A . n 
A 1 368 ALA 368 332 332 ALA ALA A . n 
A 1 369 LEU 369 333 333 LEU LEU A . n 
A 1 370 GLY 370 334 334 GLY GLY A . n 
A 1 371 PRO 371 335 335 PRO PRO A . n 
A 1 372 PRO 372 336 336 PRO PRO A . n 
A 1 373 LYS 373 337 337 LYS LYS A . n 
A 1 374 GLY 374 338 338 GLY GLY A . n 
A 1 375 ALA 375 339 339 ALA ALA A . n 
A 1 376 TYR 376 340 340 TYR TYR A . n 
A 1 377 ASP 377 341 341 ASP ASP A . n 
A 1 378 ARG 378 342 342 ARG ARG A . n 
A 1 379 THR 379 343 343 THR THR A . n 
A 1 380 THR 380 344 344 THR THR A . n 
A 1 381 PRO 381 345 345 PRO PRO A . n 
A 1 382 ASP 382 346 346 ASP ASP A . n 
A 1 383 GLY 383 347 347 GLY GLY A . n 
A 1 384 TRP 384 348 348 TRP TRP A . n 
A 1 385 GLU 385 349 349 GLU GLU A . n 
A 1 386 PHE 386 350 350 PHE PHE A . n 
A 1 387 THR 387 351 351 THR THR A . n 
A 1 388 ARG 388 352 352 ARG ARG A . n 
A 1 389 GLU 389 353 353 GLU GLU A . n 
A 1 390 PHE 390 354 354 PHE PHE A . n 
A 1 391 GLU 391 355 355 GLU GLU A . n 
A 1 392 HIS 392 356 356 HIS HIS A . n 
A 1 393 ALA 393 357 357 ALA ALA A . n 
A 1 394 SER 394 358 358 SER SER A . n 
A 1 395 VAL 395 359 359 VAL VAL A . n 
A 1 396 TRP 396 360 360 TRP TRP A . n 
A 1 397 VAL 397 361 361 VAL VAL A . n 
A 1 398 ASN 398 362 362 ASN ASN A . n 
A 1 399 THR 399 363 363 THR THR A . n 
A 1 400 GLU 400 364 364 GLU GLU A . n 
A 1 401 THR 401 365 365 THR THR A . n 
A 1 402 GLY 402 366 366 GLY GLY A . n 
A 1 403 ASN 403 367 367 ASN ASN A . n 
A 1 404 ALA 404 368 368 ALA ALA A . n 
A 1 405 LYS 405 369 369 LYS LYS A . n 
A 1 406 ILE 406 370 370 ILE ILE A . n 
A 1 407 THR 407 371 371 THR THR A . n 
A 1 408 TRP 408 372 372 TRP TRP A . n 
A 1 409 ARG 409 373 373 ARG ARG A . n 
# 
loop_
_pdbx_branch_scheme.asym_id 
_pdbx_branch_scheme.entity_id 
_pdbx_branch_scheme.mon_id 
_pdbx_branch_scheme.num 
_pdbx_branch_scheme.pdb_asym_id 
_pdbx_branch_scheme.pdb_mon_id 
_pdbx_branch_scheme.pdb_seq_num 
_pdbx_branch_scheme.auth_asym_id 
_pdbx_branch_scheme.auth_mon_id 
_pdbx_branch_scheme.auth_seq_num 
_pdbx_branch_scheme.hetero 
B 2 X6Y 1 B X6Y 1 A LIG 401 n 
B 2 X6Y 2 B X6Y 2 A LIG 401 n 
B 2 X2Y 3 B X2Y 3 A LIG 401 n 
B 2 FUC 4 B FUC 4 A LIG 401 n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 FUC ? ? FUC ? ? 'SUBJECT OF INVESTIGATION' ? 
2 X2Y ? ? X2Y ? ? 'SUBJECT OF INVESTIGATION' ? 
3 X6Y ? ? X6Y ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3 HOH 1   401 34  HOH HOH A . 
C 3 HOH 2   402 244 HOH HOH A . 
C 3 HOH 3   403 86  HOH HOH A . 
C 3 HOH 4   404 195 HOH HOH A . 
C 3 HOH 5   405 49  HOH HOH A . 
C 3 HOH 6   406 247 HOH HOH A . 
C 3 HOH 7   407 45  HOH HOH A . 
C 3 HOH 8   408 48  HOH HOH A . 
C 3 HOH 9   409 29  HOH HOH A . 
C 3 HOH 10  410 231 HOH HOH A . 
C 3 HOH 11  411 18  HOH HOH A . 
C 3 HOH 12  412 32  HOH HOH A . 
C 3 HOH 13  413 182 HOH HOH A . 
C 3 HOH 14  414 23  HOH HOH A . 
C 3 HOH 15  415 128 HOH HOH A . 
C 3 HOH 16  416 51  HOH HOH A . 
C 3 HOH 17  417 140 HOH HOH A . 
C 3 HOH 18  418 219 HOH HOH A . 
C 3 HOH 19  419 76  HOH HOH A . 
C 3 HOH 20  420 46  HOH HOH A . 
C 3 HOH 21  421 119 HOH HOH A . 
C 3 HOH 22  422 6   HOH HOH A . 
C 3 HOH 23  423 73  HOH HOH A . 
C 3 HOH 24  424 268 HOH HOH A . 
C 3 HOH 25  425 210 HOH HOH A . 
C 3 HOH 26  426 243 HOH HOH A . 
C 3 HOH 27  427 55  HOH HOH A . 
C 3 HOH 28  428 83  HOH HOH A . 
C 3 HOH 29  429 39  HOH HOH A . 
C 3 HOH 30  430 115 HOH HOH A . 
C 3 HOH 31  431 14  HOH HOH A . 
C 3 HOH 32  432 12  HOH HOH A . 
C 3 HOH 33  433 133 HOH HOH A . 
C 3 HOH 34  434 33  HOH HOH A . 
C 3 HOH 35  435 75  HOH HOH A . 
C 3 HOH 36  436 251 HOH HOH A . 
C 3 HOH 37  437 129 HOH HOH A . 
C 3 HOH 38  438 249 HOH HOH A . 
C 3 HOH 39  439 136 HOH HOH A . 
C 3 HOH 40  440 113 HOH HOH A . 
C 3 HOH 41  441 7   HOH HOH A . 
C 3 HOH 42  442 148 HOH HOH A . 
C 3 HOH 43  443 22  HOH HOH A . 
C 3 HOH 44  444 63  HOH HOH A . 
C 3 HOH 45  445 155 HOH HOH A . 
C 3 HOH 46  446 212 HOH HOH A . 
C 3 HOH 47  447 37  HOH HOH A . 
C 3 HOH 48  448 131 HOH HOH A . 
C 3 HOH 49  449 90  HOH HOH A . 
C 3 HOH 50  450 74  HOH HOH A . 
C 3 HOH 51  451 144 HOH HOH A . 
C 3 HOH 52  452 60  HOH HOH A . 
C 3 HOH 53  453 174 HOH HOH A . 
C 3 HOH 54  454 124 HOH HOH A . 
C 3 HOH 55  455 112 HOH HOH A . 
C 3 HOH 56  456 147 HOH HOH A . 
C 3 HOH 57  457 201 HOH HOH A . 
C 3 HOH 58  458 92  HOH HOH A . 
C 3 HOH 59  459 26  HOH HOH A . 
C 3 HOH 60  460 80  HOH HOH A . 
C 3 HOH 61  461 66  HOH HOH A . 
C 3 HOH 62  462 118 HOH HOH A . 
C 3 HOH 63  463 5   HOH HOH A . 
C 3 HOH 64  464 99  HOH HOH A . 
C 3 HOH 65  465 8   HOH HOH A . 
C 3 HOH 66  466 16  HOH HOH A . 
C 3 HOH 67  467 97  HOH HOH A . 
C 3 HOH 68  468 138 HOH HOH A . 
C 3 HOH 69  469 11  HOH HOH A . 
C 3 HOH 70  470 21  HOH HOH A . 
C 3 HOH 71  471 10  HOH HOH A . 
C 3 HOH 72  472 19  HOH HOH A . 
C 3 HOH 73  473 72  HOH HOH A . 
C 3 HOH 74  474 117 HOH HOH A . 
C 3 HOH 75  475 59  HOH HOH A . 
C 3 HOH 76  476 172 HOH HOH A . 
C 3 HOH 77  477 114 HOH HOH A . 
C 3 HOH 78  478 160 HOH HOH A . 
C 3 HOH 79  479 2   HOH HOH A . 
C 3 HOH 80  480 24  HOH HOH A . 
C 3 HOH 81  481 207 HOH HOH A . 
C 3 HOH 82  482 41  HOH HOH A . 
C 3 HOH 83  483 150 HOH HOH A . 
C 3 HOH 84  484 102 HOH HOH A . 
C 3 HOH 85  485 157 HOH HOH A . 
C 3 HOH 86  486 61  HOH HOH A . 
C 3 HOH 87  487 20  HOH HOH A . 
C 3 HOH 88  488 87  HOH HOH A . 
C 3 HOH 89  489 78  HOH HOH A . 
C 3 HOH 90  490 35  HOH HOH A . 
C 3 HOH 91  491 238 HOH HOH A . 
C 3 HOH 92  492 84  HOH HOH A . 
C 3 HOH 93  493 237 HOH HOH A . 
C 3 HOH 94  494 159 HOH HOH A . 
C 3 HOH 95  495 191 HOH HOH A . 
C 3 HOH 96  496 3   HOH HOH A . 
C 3 HOH 97  497 53  HOH HOH A . 
C 3 HOH 98  498 146 HOH HOH A . 
C 3 HOH 99  499 47  HOH HOH A . 
C 3 HOH 100 500 1   HOH HOH A . 
C 3 HOH 101 501 43  HOH HOH A . 
C 3 HOH 102 502 65  HOH HOH A . 
C 3 HOH 103 503 232 HOH HOH A . 
C 3 HOH 104 504 38  HOH HOH A . 
C 3 HOH 105 505 141 HOH HOH A . 
C 3 HOH 106 506 217 HOH HOH A . 
C 3 HOH 107 507 25  HOH HOH A . 
C 3 HOH 108 508 221 HOH HOH A . 
C 3 HOH 109 509 4   HOH HOH A . 
C 3 HOH 110 510 54  HOH HOH A . 
C 3 HOH 111 511 197 HOH HOH A . 
C 3 HOH 112 512 15  HOH HOH A . 
C 3 HOH 113 513 79  HOH HOH A . 
C 3 HOH 114 514 13  HOH HOH A . 
C 3 HOH 115 515 208 HOH HOH A . 
C 3 HOH 116 516 95  HOH HOH A . 
C 3 HOH 117 517 126 HOH HOH A . 
C 3 HOH 118 518 110 HOH HOH A . 
C 3 HOH 119 519 69  HOH HOH A . 
C 3 HOH 120 520 176 HOH HOH A . 
C 3 HOH 121 521 162 HOH HOH A . 
C 3 HOH 122 522 260 HOH HOH A . 
C 3 HOH 123 523 204 HOH HOH A . 
C 3 HOH 124 524 209 HOH HOH A . 
C 3 HOH 125 525 151 HOH HOH A . 
C 3 HOH 126 526 106 HOH HOH A . 
C 3 HOH 127 527 96  HOH HOH A . 
C 3 HOH 128 528 200 HOH HOH A . 
C 3 HOH 129 529 81  HOH HOH A . 
C 3 HOH 130 530 130 HOH HOH A . 
C 3 HOH 131 531 67  HOH HOH A . 
C 3 HOH 132 532 94  HOH HOH A . 
C 3 HOH 133 533 71  HOH HOH A . 
C 3 HOH 134 534 31  HOH HOH A . 
C 3 HOH 135 535 165 HOH HOH A . 
C 3 HOH 136 536 199 HOH HOH A . 
C 3 HOH 137 537 161 HOH HOH A . 
C 3 HOH 138 538 82  HOH HOH A . 
C 3 HOH 139 539 44  HOH HOH A . 
C 3 HOH 140 540 100 HOH HOH A . 
C 3 HOH 141 541 30  HOH HOH A . 
C 3 HOH 142 542 246 HOH HOH A . 
C 3 HOH 143 543 241 HOH HOH A . 
C 3 HOH 144 544 186 HOH HOH A . 
C 3 HOH 145 545 188 HOH HOH A . 
C 3 HOH 146 546 70  HOH HOH A . 
C 3 HOH 147 547 56  HOH HOH A . 
C 3 HOH 148 548 202 HOH HOH A . 
C 3 HOH 149 549 235 HOH HOH A . 
C 3 HOH 150 550 127 HOH HOH A . 
C 3 HOH 151 551 108 HOH HOH A . 
C 3 HOH 152 552 64  HOH HOH A . 
C 3 HOH 153 553 152 HOH HOH A . 
C 3 HOH 154 554 107 HOH HOH A . 
C 3 HOH 155 555 27  HOH HOH A . 
C 3 HOH 156 556 125 HOH HOH A . 
C 3 HOH 157 557 103 HOH HOH A . 
C 3 HOH 158 558 143 HOH HOH A . 
C 3 HOH 159 559 177 HOH HOH A . 
C 3 HOH 160 560 111 HOH HOH A . 
C 3 HOH 161 561 224 HOH HOH A . 
C 3 HOH 162 562 28  HOH HOH A . 
C 3 HOH 163 563 262 HOH HOH A . 
C 3 HOH 164 564 170 HOH HOH A . 
C 3 HOH 165 565 276 HOH HOH A . 
C 3 HOH 166 566 187 HOH HOH A . 
C 3 HOH 167 567 194 HOH HOH A . 
C 3 HOH 168 568 135 HOH HOH A . 
C 3 HOH 169 569 132 HOH HOH A . 
C 3 HOH 170 570 273 HOH HOH A . 
C 3 HOH 171 571 36  HOH HOH A . 
C 3 HOH 172 572 98  HOH HOH A . 
C 3 HOH 173 573 250 HOH HOH A . 
C 3 HOH 174 574 9   HOH HOH A . 
C 3 HOH 175 575 42  HOH HOH A . 
C 3 HOH 176 576 85  HOH HOH A . 
C 3 HOH 177 577 211 HOH HOH A . 
C 3 HOH 178 578 164 HOH HOH A . 
C 3 HOH 179 579 17  HOH HOH A . 
C 3 HOH 180 580 58  HOH HOH A . 
C 3 HOH 181 581 121 HOH HOH A . 
C 3 HOH 182 582 180 HOH HOH A . 
C 3 HOH 183 583 137 HOH HOH A . 
C 3 HOH 184 584 169 HOH HOH A . 
C 3 HOH 185 585 245 HOH HOH A . 
C 3 HOH 186 586 52  HOH HOH A . 
C 3 HOH 187 587 154 HOH HOH A . 
C 3 HOH 188 588 259 HOH HOH A . 
C 3 HOH 189 589 139 HOH HOH A . 
C 3 HOH 190 590 89  HOH HOH A . 
C 3 HOH 191 591 62  HOH HOH A . 
C 3 HOH 192 592 227 HOH HOH A . 
C 3 HOH 193 593 50  HOH HOH A . 
C 3 HOH 194 594 120 HOH HOH A . 
C 3 HOH 195 595 116 HOH HOH A . 
C 3 HOH 196 596 57  HOH HOH A . 
C 3 HOH 197 597 163 HOH HOH A . 
C 3 HOH 198 598 123 HOH HOH A . 
C 3 HOH 199 599 205 HOH HOH A . 
C 3 HOH 200 600 184 HOH HOH A . 
C 3 HOH 201 601 122 HOH HOH A . 
C 3 HOH 202 602 40  HOH HOH A . 
C 3 HOH 203 603 145 HOH HOH A . 
C 3 HOH 204 604 101 HOH HOH A . 
C 3 HOH 205 605 271 HOH HOH A . 
C 3 HOH 206 606 88  HOH HOH A . 
C 3 HOH 207 607 248 HOH HOH A . 
C 3 HOH 208 608 225 HOH HOH A . 
C 3 HOH 209 609 189 HOH HOH A . 
C 3 HOH 210 610 263 HOH HOH A . 
C 3 HOH 211 611 134 HOH HOH A . 
C 3 HOH 212 612 234 HOH HOH A . 
C 3 HOH 213 613 256 HOH HOH A . 
C 3 HOH 214 614 215 HOH HOH A . 
C 3 HOH 215 615 213 HOH HOH A . 
C 3 HOH 216 616 166 HOH HOH A . 
C 3 HOH 217 617 216 HOH HOH A . 
C 3 HOH 218 618 192 HOH HOH A . 
C 3 HOH 219 619 261 HOH HOH A . 
C 3 HOH 220 620 214 HOH HOH A . 
C 3 HOH 221 621 236 HOH HOH A . 
C 3 HOH 222 622 183 HOH HOH A . 
C 3 HOH 223 623 203 HOH HOH A . 
C 3 HOH 224 624 240 HOH HOH A . 
C 3 HOH 225 625 255 HOH HOH A . 
C 3 HOH 226 626 270 HOH HOH A . 
C 3 HOH 227 627 272 HOH HOH A . 
C 3 HOH 228 628 253 HOH HOH A . 
C 3 HOH 229 629 109 HOH HOH A . 
C 3 HOH 230 630 257 HOH HOH A . 
C 3 HOH 231 631 77  HOH HOH A . 
C 3 HOH 232 632 175 HOH HOH A . 
C 3 HOH 233 633 185 HOH HOH A . 
C 3 HOH 234 634 222 HOH HOH A . 
C 3 HOH 235 635 105 HOH HOH A . 
C 3 HOH 236 636 104 HOH HOH A . 
C 3 HOH 237 637 68  HOH HOH A . 
C 3 HOH 238 638 233 HOH HOH A . 
C 3 HOH 239 639 269 HOH HOH A . 
C 3 HOH 240 640 171 HOH HOH A . 
C 3 HOH 241 641 168 HOH HOH A . 
C 3 HOH 242 642 275 HOH HOH A . 
C 3 HOH 243 643 220 HOH HOH A . 
C 3 HOH 244 644 254 HOH HOH A . 
C 3 HOH 245 645 193 HOH HOH A . 
C 3 HOH 246 646 206 HOH HOH A . 
C 3 HOH 247 647 252 HOH HOH A . 
C 3 HOH 248 648 93  HOH HOH A . 
C 3 HOH 249 649 274 HOH HOH A . 
C 3 HOH 250 650 181 HOH HOH A . 
C 3 HOH 251 651 277 HOH HOH A . 
C 3 HOH 252 652 198 HOH HOH A . 
C 3 HOH 253 653 265 HOH HOH A . 
C 3 HOH 254 654 228 HOH HOH A . 
C 3 HOH 255 655 226 HOH HOH A . 
C 3 HOH 256 656 156 HOH HOH A . 
C 3 HOH 257 657 142 HOH HOH A . 
C 3 HOH 258 658 196 HOH HOH A . 
C 3 HOH 259 659 230 HOH HOH A . 
C 3 HOH 260 660 242 HOH HOH A . 
C 3 HOH 261 661 178 HOH HOH A . 
C 3 HOH 262 662 173 HOH HOH A . 
C 3 HOH 263 663 223 HOH HOH A . 
C 3 HOH 264 664 179 HOH HOH A . 
C 3 HOH 265 665 264 HOH HOH A . 
C 3 HOH 266 666 239 HOH HOH A . 
C 3 HOH 267 667 229 HOH HOH A . 
C 3 HOH 268 668 153 HOH HOH A . 
C 3 HOH 269 669 278 HOH HOH A . 
C 3 HOH 270 670 258 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A ARG 136 ? NE  ? A ARG 172 NE  
2  1 Y 1 A ARG 136 ? CZ  ? A ARG 172 CZ  
3  1 Y 1 A ARG 136 ? NH1 ? A ARG 172 NH1 
4  1 Y 1 A ARG 136 ? NH2 ? A ARG 172 NH2 
5  1 Y 1 A GLU 185 ? CG  ? A GLU 221 CG  
6  1 Y 1 A GLU 185 ? CD  ? A GLU 221 CD  
7  1 Y 1 A GLU 185 ? OE1 ? A GLU 221 OE1 
8  1 Y 1 A GLU 185 ? OE2 ? A GLU 221 OE2 
9  1 Y 1 A ASP 216 ? CG  ? A ASP 252 CG  
10 1 Y 1 A ASP 216 ? OD1 ? A ASP 252 OD1 
11 1 Y 1 A ASP 216 ? OD2 ? A ASP 252 OD2 
12 1 Y 1 A LYS 290 ? CG  ? A LYS 326 CG  
13 1 Y 1 A LYS 290 ? CD  ? A LYS 326 CD  
14 1 Y 1 A LYS 290 ? CE  ? A LYS 326 CE  
15 1 Y 1 A LYS 290 ? NZ  ? A LYS 326 NZ  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? '(1.20.1_4487: ???)' 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .                    2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .                    3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .                    4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9JP2 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     148.360 
_cell.length_a_esd                 ? 
_cell.length_b                     148.360 
_cell.length_b_esd                 ? 
_cell.length_c                     42.028 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        9 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9JP2 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                146 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'H 3' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9JP2 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             1.90 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          35.38 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.03 M Citric acid, 0.07 M BIS-TRIS propane / pH 7.6, 20% w/v Polyethylene glycol 3,350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            290 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS3 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-06-23 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97923 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL19U1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97923 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL19U1 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9JP2 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.02 
_reflns.d_resolution_low                               42.83 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     20953 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           92.0 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                9.5 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          13.6 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               0.97 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.134 
_reflns.pdbx_Rpim_I_all                                0.043 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       199565 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.998 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.127 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.02 
_reflns_shell.d_res_low                                     2.12 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           20423 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2254 
_reflns_shell.percent_possible_obs                          67.7 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               9.1 
_reflns_shell.pdbx_chi_squared                              0.87 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     2.4 
_reflns_shell.pdbx_Rrim_I_all                               0.986 
_reflns_shell.pdbx_Rpim_I_all                               0.323 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.767 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.930 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9JP2 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.02 
_refine.ls_d_res_low                             42.83 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     20952 
_refine.ls_number_reflns_R_free                  1994 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    91.96 
_refine.ls_percent_reflns_R_free                 9.52 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1740 
_refine.ls_R_factor_R_free                       0.2171 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1695 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.96 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.10 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 23.90 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.23 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.02 
_refine_hist.d_res_low                        42.83 
_refine_hist.number_atoms_solvent             270 
_refine_hist.number_atoms_total               3199 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2872 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         57 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.007 ? 3026 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.938 ? 4109 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 7.650 ? 390  ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.052 ? 427  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.008 ? 518  ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.02 2.04  . . 87  820  100.00 . . . . 0.2615 . . . . . . . . . . . 0.3047 
'X-RAY DIFFRACTION' 2.08 2.12  . . 122 1171 100.00 . . . . 0.2097 . . . . . . . . . . . 0.2753 
'X-RAY DIFFRACTION' 2.12 2.18  . . 157 1459 100.00 . . . . 0.2121 . . . . . . . . . . . 0.2840 
'X-RAY DIFFRACTION' 2.18 2.22  . . 89  827  100.00 . . . . 0.2018 . . . . . . . . . . . 0.2533 
'X-RAY DIFFRACTION' 2.26 2.33  . . 153 1428 100.00 . . . . 0.2051 . . . . . . . . . . . 0.2475 
'X-RAY DIFFRACTION' 2.34 2.43  . . 156 1460 100.00 . . . . 0.1852 . . . . . . . . . . . 0.2532 
'X-RAY DIFFRACTION' 2.43 2.54  . . 153 1458 100.00 . . . . 0.2051 . . . . . . . . . . . 0.2547 
'X-RAY DIFFRACTION' 2.54 2.67  . . 153 1481 100.00 . . . . 0.1942 . . . . . . . . . . . 0.3075 
'X-RAY DIFFRACTION' 2.67 2.84  . . 155 1498 100.00 . . . . 0.1963 . . . . . . . . . . . 0.2302 
'X-RAY DIFFRACTION' 2.84 3.06  . . 147 1453 100.00 . . . . 0.1770 . . . . . . . . . . . 0.2209 
'X-RAY DIFFRACTION' 3.06 3.37  . . 152 1484 100.00 . . . . 0.1778 . . . . . . . . . . . 0.2234 
'X-RAY DIFFRACTION' 3.37 3.85  . . 156 1473 100.00 . . . . 0.1413 . . . . . . . . . . . 0.2122 
'X-RAY DIFFRACTION' 3.86 4.86  . . 157 1481 100.00 . . . . 0.1333 . . . . . . . . . . . 0.1781 
'X-RAY DIFFRACTION' 4.86 42.83 . . 157 1465 100.00 . . . . 0.1518 . . . . . . . . . . . 0.1554 
# 
_struct.entry_id                     9JP2 
_struct.title                        'COMPLEX STRUCTURE OF ENDO-1,3-FUCANASE WITH FUCOTETRAOSE' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9JP2 
_struct_keywords.text            'Endo-1.3-fucanase, GH168, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A0A5C6D8T6_9BACT 
_struct_ref.pdbx_db_accession          A0A5C6D8T6 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;LGQHYLNSDGSRFVPKDFYPKFSWDTTPMYYMFGDTTRLLEPEEVEFIAERTDFLCIEKSHGRTPLGAAELGAKHEAAAF
KKIKPDMKVLFYFNSAYAWPFTSYNQAFTRNKIDEHPKLKSFLIVDPKTAELAHRRNVFFFDVLNPELREWWSTTVAKGV
AESGCDGAFIDQMHGFAWLRADKSEDVQKAMGEMMALLKRKMGPDKILLGNNANQDIAKDAFPVMDASMFEHYNEKLLSK
ESLLQDWDDMLRIAQAGKMSIFRIGVESDPRASQDQGRRGSRRDQPVLAKERAEYYLACYLIGAQPYSYFQYGWGWTLSS
GSLHEFPELRKALGPPKGAYDRTTPDGWEFTREFEHASVWVNTETGNAKITWR
;
_struct_ref.pdbx_align_begin           23 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9JP2 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 37 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 409 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             A0A5C6D8T6 
_struct_ref_seq.db_align_beg                  23 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  395 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       373 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9JP2 MET A 1  ? UNP A0A5C6D8T6 ? ? 'initiating methionine' -35 1  
1 9JP2 GLY A 2  ? UNP A0A5C6D8T6 ? ? 'expression tag'        -34 2  
1 9JP2 SER A 3  ? UNP A0A5C6D8T6 ? ? 'expression tag'        -33 3  
1 9JP2 SER A 4  ? UNP A0A5C6D8T6 ? ? 'expression tag'        -32 4  
1 9JP2 HIS A 5  ? UNP A0A5C6D8T6 ? ? 'expression tag'        -31 5  
1 9JP2 HIS A 6  ? UNP A0A5C6D8T6 ? ? 'expression tag'        -30 6  
1 9JP2 HIS A 7  ? UNP A0A5C6D8T6 ? ? 'expression tag'        -29 7  
1 9JP2 HIS A 8  ? UNP A0A5C6D8T6 ? ? 'expression tag'        -28 8  
1 9JP2 HIS A 9  ? UNP A0A5C6D8T6 ? ? 'expression tag'        -27 9  
1 9JP2 HIS A 10 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -26 10 
1 9JP2 SER A 11 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -25 11 
1 9JP2 SER A 12 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -24 12 
1 9JP2 GLY A 13 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -23 13 
1 9JP2 LEU A 14 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -22 14 
1 9JP2 VAL A 15 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -21 15 
1 9JP2 PRO A 16 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -20 16 
1 9JP2 ARG A 17 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -19 17 
1 9JP2 GLY A 18 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -18 18 
1 9JP2 SER A 19 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -17 19 
1 9JP2 HIS A 20 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -16 20 
1 9JP2 MET A 21 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -15 21 
1 9JP2 ALA A 22 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -14 22 
1 9JP2 SER A 23 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -13 23 
1 9JP2 MET A 24 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -12 24 
1 9JP2 THR A 25 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -11 25 
1 9JP2 GLY A 26 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -10 26 
1 9JP2 GLY A 27 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -9  27 
1 9JP2 GLN A 28 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -8  28 
1 9JP2 GLN A 29 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -7  29 
1 9JP2 MET A 30 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -6  30 
1 9JP2 GLY A 31 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -5  31 
1 9JP2 ARG A 32 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -4  32 
1 9JP2 GLY A 33 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -3  33 
1 9JP2 SER A 34 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -2  34 
1 9JP2 GLU A 35 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -1  35 
1 9JP2 PHE A 36 ? UNP A0A5C6D8T6 ? ? 'expression tag'        0   36 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLU A 77  ? THR A 88  ? GLU A 41  THR A 52  1 ? 12 
HELX_P HELX_P2  AA2 GLY A 98  ? GLY A 103 ? GLY A 62  GLY A 67  1 ? 6  
HELX_P HELX_P3  AA3 ALA A 104 ? LYS A 120 ? ALA A 68  LYS A 84  1 ? 17 
HELX_P HELX_P4  AA4 THR A 138 ? GLN A 142 ? THR A 102 GLN A 106 5 ? 5  
HELX_P HELX_P5  AA5 LYS A 148 ? GLU A 151 ? LYS A 112 GLU A 115 5 ? 4  
HELX_P HELX_P6  AA6 HIS A 152 ? SER A 157 ? HIS A 116 SER A 121 1 ? 6  
HELX_P HELX_P7  AA7 ASN A 181 ? GLY A 200 ? ASN A 145 GLY A 164 1 ? 20 
HELX_P HELX_P8  AA8 PHE A 212 ? ASP A 218 ? PHE A 176 ASP A 182 5 ? 7  
HELX_P HELX_P9  AA9 LYS A 219 ? GLY A 239 ? LYS A 183 GLY A 203 1 ? 21 
HELX_P HELX_P10 AB1 GLN A 251 ? LYS A 255 ? GLN A 215 LYS A 219 5 ? 5  
HELX_P HELX_P11 AB2 ALA A 257 ? MET A 261 ? ALA A 221 MET A 225 5 ? 5  
HELX_P HELX_P12 AB3 GLU A 271 ? LEU A 274 ? GLU A 235 LEU A 238 5 ? 4  
HELX_P HELX_P13 AB4 SER A 275 ? ALA A 292 ? SER A 239 ALA A 256 1 ? 18 
HELX_P HELX_P14 AB5 GLU A 303 ? ASP A 305 ? GLU A 267 ASP A 269 5 ? 3  
HELX_P HELX_P15 AB6 PRO A 322 ? ALA A 340 ? PRO A 286 ALA A 304 1 ? 19 
HELX_P HELX_P16 AB7 THR A 353 ? GLY A 357 ? THR A 317 GLY A 321 5 ? 5  
HELX_P HELX_P17 AB8 PHE A 362 ? LYS A 367 ? PHE A 326 LYS A 331 5 ? 6  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
covale1 covale none ? B X6Y . O3 ? ? ? 1_555 B X6Y . C1 ? ? B X6Y 1 B X6Y 2 1_555 ? ? ? ? ? ? ? 1.376 ? ? 
covale2 covale one  ? B X6Y . O3 ? ? ? 1_555 B X2Y . C1 ? ? B X6Y 2 B X2Y 3 1_555 ? ? ? ? ? ? ? 1.357 ? ? 
covale3 covale both ? B X2Y . O3 ? ? ? 1_555 B FUC . C1 ? ? B X2Y 3 B FUC 4 1_555 ? ? ? ? ? ? ? 1.361 ? ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 8 ? 
AA2 ? 2 ? 
AA3 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? parallel      
AA1 3 4 ? parallel      
AA1 4 5 ? parallel      
AA1 5 6 ? parallel      
AA1 6 7 ? parallel      
AA1 7 8 ? parallel      
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 TYR A 67  ? PHE A 69  ? TYR A 31  PHE A 33  
AA1 2 PHE A 90  ? ILE A 93  ? PHE A 54  ILE A 57  
AA1 3 LYS A 124 ? ASN A 130 ? LYS A 88  ASN A 94  
AA1 4 GLY A 203 ? ASP A 207 ? GLY A 167 ASP A 171 
AA1 5 ILE A 243 ? ASN A 247 ? ILE A 207 ASN A 211 
AA1 6 ALA A 263 ? PHE A 266 ? ALA A 227 PHE A 230 
AA1 7 MET A 295 ? GLY A 301 ? MET A 259 GLY A 265 
AA1 8 SER A 344 ? GLY A 349 ? SER A 308 GLY A 313 
AA2 1 HIS A 170 ? ARG A 171 ? HIS A 134 ARG A 135 
AA2 2 VAL A 174 ? PHE A 175 ? VAL A 138 PHE A 139 
AA3 1 ASP A 377 ? ARG A 378 ? ASP A 341 ARG A 342 
AA3 2 GLU A 385 ? PHE A 390 ? GLU A 349 PHE A 354 
AA3 3 ALA A 393 ? ASN A 398 ? ALA A 357 ASN A 362 
AA3 4 ASN A 403 ? TRP A 408 ? ASN A 367 TRP A 372 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N TYR A 67  ? N TYR A 31  O CYS A 92  ? O CYS A 56  
AA1 2 3 N LEU A 91  ? N LEU A 55  O LYS A 124 ? O LYS A 88  
AA1 3 4 N PHE A 127 ? N PHE A 91  O GLY A 203 ? O GLY A 167 
AA1 4 5 N ILE A 206 ? N ILE A 170 O LEU A 245 ? O LEU A 209 
AA1 5 6 N GLY A 246 ? N GLY A 210 O ALA A 263 ? O ALA A 227 
AA1 6 7 N PHE A 266 ? N PHE A 230 O ILE A 297 ? O ILE A 261 
AA1 7 8 N PHE A 298 ? N PHE A 262 O TYR A 345 ? O TYR A 309 
AA2 1 2 N ARG A 171 ? N ARG A 135 O VAL A 174 ? O VAL A 138 
AA3 1 2 N ASP A 377 ? N ASP A 341 O THR A 387 ? O THR A 351 
AA3 2 3 N PHE A 390 ? N PHE A 354 O ALA A 393 ? O ALA A 357 
AA3 3 4 N SER A 394 ? N SER A 358 O THR A 407 ? O THR A 371 
# 
_pdbx_entry_details.entry_id                   9JP2 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 O  A HOH 561 ? ? O A HOH 654 ? ? 1.85 
2 1 O  A HOH 614 ? ? O A HOH 626 ? ? 1.92 
3 1 O  A HOH 530 ? ? O A HOH 645 ? ? 2.02 
4 1 O  A HOH 591 ? ? O A HOH 628 ? ? 2.05 
5 1 O  A HOH 425 ? ? O A HOH 597 ? ? 2.06 
6 1 O  A HOH 568 ? ? O A HOH 598 ? ? 2.11 
7 1 OH A TYR 5   ? ? O A HOH 401 ? ? 2.13 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 PRO A 100 ? ? -80.18  31.53  
2 1 ALA A 130 ? ? 51.40   18.70  
3 1 GLN A 172 ? ? 79.72   122.05 
4 1 ARG A 180 ? ? -152.46 61.90  
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 669 ? 6.54 . 
2 1 O ? A HOH 670 ? 6.86 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET -35 ? A MET 1   
2  1 Y 1 A GLY -34 ? A GLY 2   
3  1 Y 1 A SER -33 ? A SER 3   
4  1 Y 1 A SER -32 ? A SER 4   
5  1 Y 1 A HIS -31 ? A HIS 5   
6  1 Y 1 A HIS -30 ? A HIS 6   
7  1 Y 1 A HIS -29 ? A HIS 7   
8  1 Y 1 A HIS -28 ? A HIS 8   
9  1 Y 1 A HIS -27 ? A HIS 9   
10 1 Y 1 A HIS -26 ? A HIS 10  
11 1 Y 1 A SER -25 ? A SER 11  
12 1 Y 1 A SER -24 ? A SER 12  
13 1 Y 1 A GLY -23 ? A GLY 13  
14 1 Y 1 A LEU -22 ? A LEU 14  
15 1 Y 1 A VAL -21 ? A VAL 15  
16 1 Y 1 A PRO -20 ? A PRO 16  
17 1 Y 1 A ARG -19 ? A ARG 17  
18 1 Y 1 A GLY -18 ? A GLY 18  
19 1 Y 1 A SER -17 ? A SER 19  
20 1 Y 1 A HIS -16 ? A HIS 20  
21 1 Y 1 A MET -15 ? A MET 21  
22 1 Y 1 A ALA -14 ? A ALA 22  
23 1 Y 1 A SER -13 ? A SER 23  
24 1 Y 1 A MET -12 ? A MET 24  
25 1 Y 1 A THR -11 ? A THR 25  
26 1 Y 1 A GLY -10 ? A GLY 26  
27 1 Y 1 A GLY -9  ? A GLY 27  
28 1 Y 1 A GLN -8  ? A GLN 28  
29 1 Y 1 A GLN -7  ? A GLN 29  
30 1 Y 1 A MET -6  ? A MET 30  
31 1 Y 1 A GLY -5  ? A GLY 31  
32 1 Y 1 A ARG -4  ? A ARG 32  
33 1 Y 1 A GLY -3  ? A GLY 33  
34 1 Y 1 A SER -2  ? A SER 34  
35 1 Y 1 A GLU -1  ? A GLU 35  
36 1 Y 1 A PHE 0   ? A PHE 36  
37 1 Y 1 A LEU 1   ? A LEU 37  
38 1 Y 1 A GLY 2   ? A GLY 38  
39 1 Y 1 A GLN 3   ? A GLN 39  
40 1 Y 1 A PRO 270 ? A PRO 306 
41 1 Y 1 A ARG 271 ? A ARG 307 
42 1 Y 1 A ALA 272 ? A ALA 308 
43 1 Y 1 A SER 273 ? A SER 309 
44 1 Y 1 A GLN 274 ? A GLN 310 
45 1 Y 1 A ASP 275 ? A ASP 311 
46 1 Y 1 A GLN 276 ? A GLN 312 
47 1 Y 1 A GLY 277 ? A GLY 313 
48 1 Y 1 A ARG 278 ? A ARG 314 
49 1 Y 1 A ARG 279 ? A ARG 315 
50 1 Y 1 A GLY 280 ? A GLY 316 
51 1 Y 1 A SER 281 ? A SER 317 
52 1 Y 1 A ARG 282 ? A ARG 318 
53 1 Y 1 A ARG 283 ? A ARG 319 
54 1 Y 1 A ASP 284 ? A ASP 320 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
FUC C1   C N R 88  
FUC C2   C N S 89  
FUC C3   C N R 90  
FUC C4   C N S 91  
FUC C5   C N S 92  
FUC C6   C N N 93  
FUC O1   O N N 94  
FUC O2   O N N 95  
FUC O3   O N N 96  
FUC O4   O N N 97  
FUC O5   O N N 98  
FUC H1   H N N 99  
FUC H2   H N N 100 
FUC H3   H N N 101 
FUC H4   H N N 102 
FUC H5   H N N 103 
FUC H61  H N N 104 
FUC H62  H N N 105 
FUC H63  H N N 106 
FUC HO1  H N N 107 
FUC HO2  H N N 108 
FUC HO3  H N N 109 
FUC HO4  H N N 110 
GLN N    N N N 111 
GLN CA   C N S 112 
GLN C    C N N 113 
GLN O    O N N 114 
GLN CB   C N N 115 
GLN CG   C N N 116 
GLN CD   C N N 117 
GLN OE1  O N N 118 
GLN NE2  N N N 119 
GLN OXT  O N N 120 
GLN H    H N N 121 
GLN H2   H N N 122 
GLN HA   H N N 123 
GLN HB2  H N N 124 
GLN HB3  H N N 125 
GLN HG2  H N N 126 
GLN HG3  H N N 127 
GLN HE21 H N N 128 
GLN HE22 H N N 129 
GLN HXT  H N N 130 
GLU N    N N N 131 
GLU CA   C N S 132 
GLU C    C N N 133 
GLU O    O N N 134 
GLU CB   C N N 135 
GLU CG   C N N 136 
GLU CD   C N N 137 
GLU OE1  O N N 138 
GLU OE2  O N N 139 
GLU OXT  O N N 140 
GLU H    H N N 141 
GLU H2   H N N 142 
GLU HA   H N N 143 
GLU HB2  H N N 144 
GLU HB3  H N N 145 
GLU HG2  H N N 146 
GLU HG3  H N N 147 
GLU HE2  H N N 148 
GLU HXT  H N N 149 
GLY N    N N N 150 
GLY CA   C N N 151 
GLY C    C N N 152 
GLY O    O N N 153 
GLY OXT  O N N 154 
GLY H    H N N 155 
GLY H2   H N N 156 
GLY HA2  H N N 157 
GLY HA3  H N N 158 
GLY HXT  H N N 159 
HIS N    N N N 160 
HIS CA   C N S 161 
HIS C    C N N 162 
HIS O    O N N 163 
HIS CB   C N N 164 
HIS CG   C Y N 165 
HIS ND1  N Y N 166 
HIS CD2  C Y N 167 
HIS CE1  C Y N 168 
HIS NE2  N Y N 169 
HIS OXT  O N N 170 
HIS H    H N N 171 
HIS H2   H N N 172 
HIS HA   H N N 173 
HIS HB2  H N N 174 
HIS HB3  H N N 175 
HIS HD1  H N N 176 
HIS HD2  H N N 177 
HIS HE1  H N N 178 
HIS HE2  H N N 179 
HIS HXT  H N N 180 
HOH O    O N N 181 
HOH H1   H N N 182 
HOH H2   H N N 183 
ILE N    N N N 184 
ILE CA   C N S 185 
ILE C    C N N 186 
ILE O    O N N 187 
ILE CB   C N S 188 
ILE CG1  C N N 189 
ILE CG2  C N N 190 
ILE CD1  C N N 191 
ILE OXT  O N N 192 
ILE H    H N N 193 
ILE H2   H N N 194 
ILE HA   H N N 195 
ILE HB   H N N 196 
ILE HG12 H N N 197 
ILE HG13 H N N 198 
ILE HG21 H N N 199 
ILE HG22 H N N 200 
ILE HG23 H N N 201 
ILE HD11 H N N 202 
ILE HD12 H N N 203 
ILE HD13 H N N 204 
ILE HXT  H N N 205 
LEU N    N N N 206 
LEU CA   C N S 207 
LEU C    C N N 208 
LEU O    O N N 209 
LEU CB   C N N 210 
LEU CG   C N N 211 
LEU CD1  C N N 212 
LEU CD2  C N N 213 
LEU OXT  O N N 214 
LEU H    H N N 215 
LEU H2   H N N 216 
LEU HA   H N N 217 
LEU HB2  H N N 218 
LEU HB3  H N N 219 
LEU HG   H N N 220 
LEU HD11 H N N 221 
LEU HD12 H N N 222 
LEU HD13 H N N 223 
LEU HD21 H N N 224 
LEU HD22 H N N 225 
LEU HD23 H N N 226 
LEU HXT  H N N 227 
LYS N    N N N 228 
LYS CA   C N S 229 
LYS C    C N N 230 
LYS O    O N N 231 
LYS CB   C N N 232 
LYS CG   C N N 233 
LYS CD   C N N 234 
LYS CE   C N N 235 
LYS NZ   N N N 236 
LYS OXT  O N N 237 
LYS H    H N N 238 
LYS H2   H N N 239 
LYS HA   H N N 240 
LYS HB2  H N N 241 
LYS HB3  H N N 242 
LYS HG2  H N N 243 
LYS HG3  H N N 244 
LYS HD2  H N N 245 
LYS HD3  H N N 246 
LYS HE2  H N N 247 
LYS HE3  H N N 248 
LYS HZ1  H N N 249 
LYS HZ2  H N N 250 
LYS HZ3  H N N 251 
LYS HXT  H N N 252 
MET N    N N N 253 
MET CA   C N S 254 
MET C    C N N 255 
MET O    O N N 256 
MET CB   C N N 257 
MET CG   C N N 258 
MET SD   S N N 259 
MET CE   C N N 260 
MET OXT  O N N 261 
MET H    H N N 262 
MET H2   H N N 263 
MET HA   H N N 264 
MET HB2  H N N 265 
MET HB3  H N N 266 
MET HG2  H N N 267 
MET HG3  H N N 268 
MET HE1  H N N 269 
MET HE2  H N N 270 
MET HE3  H N N 271 
MET HXT  H N N 272 
PHE N    N N N 273 
PHE CA   C N S 274 
PHE C    C N N 275 
PHE O    O N N 276 
PHE CB   C N N 277 
PHE CG   C Y N 278 
PHE CD1  C Y N 279 
PHE CD2  C Y N 280 
PHE CE1  C Y N 281 
PHE CE2  C Y N 282 
PHE CZ   C Y N 283 
PHE OXT  O N N 284 
PHE H    H N N 285 
PHE H2   H N N 286 
PHE HA   H N N 287 
PHE HB2  H N N 288 
PHE HB3  H N N 289 
PHE HD1  H N N 290 
PHE HD2  H N N 291 
PHE HE1  H N N 292 
PHE HE2  H N N 293 
PHE HZ   H N N 294 
PHE HXT  H N N 295 
PRO N    N N N 296 
PRO CA   C N S 297 
PRO C    C N N 298 
PRO O    O N N 299 
PRO CB   C N N 300 
PRO CG   C N N 301 
PRO CD   C N N 302 
PRO OXT  O N N 303 
PRO H    H N N 304 
PRO HA   H N N 305 
PRO HB2  H N N 306 
PRO HB3  H N N 307 
PRO HG2  H N N 308 
PRO HG3  H N N 309 
PRO HD2  H N N 310 
PRO HD3  H N N 311 
PRO HXT  H N N 312 
SER N    N N N 313 
SER CA   C N S 314 
SER C    C N N 315 
SER O    O N N 316 
SER CB   C N N 317 
SER OG   O N N 318 
SER OXT  O N N 319 
SER H    H N N 320 
SER H2   H N N 321 
SER HA   H N N 322 
SER HB2  H N N 323 
SER HB3  H N N 324 
SER HG   H N N 325 
SER HXT  H N N 326 
THR N    N N N 327 
THR CA   C N S 328 
THR C    C N N 329 
THR O    O N N 330 
THR CB   C N R 331 
THR OG1  O N N 332 
THR CG2  C N N 333 
THR OXT  O N N 334 
THR H    H N N 335 
THR H2   H N N 336 
THR HA   H N N 337 
THR HB   H N N 338 
THR HG1  H N N 339 
THR HG21 H N N 340 
THR HG22 H N N 341 
THR HG23 H N N 342 
THR HXT  H N N 343 
TRP N    N N N 344 
TRP CA   C N S 345 
TRP C    C N N 346 
TRP O    O N N 347 
TRP CB   C N N 348 
TRP CG   C Y N 349 
TRP CD1  C Y N 350 
TRP CD2  C Y N 351 
TRP NE1  N Y N 352 
TRP CE2  C Y N 353 
TRP CE3  C Y N 354 
TRP CZ2  C Y N 355 
TRP CZ3  C Y N 356 
TRP CH2  C Y N 357 
TRP OXT  O N N 358 
TRP H    H N N 359 
TRP H2   H N N 360 
TRP HA   H N N 361 
TRP HB2  H N N 362 
TRP HB3  H N N 363 
TRP HD1  H N N 364 
TRP HE1  H N N 365 
TRP HE3  H N N 366 
TRP HZ2  H N N 367 
TRP HZ3  H N N 368 
TRP HH2  H N N 369 
TRP HXT  H N N 370 
TYR N    N N N 371 
TYR CA   C N S 372 
TYR C    C N N 373 
TYR O    O N N 374 
TYR CB   C N N 375 
TYR CG   C Y N 376 
TYR CD1  C Y N 377 
TYR CD2  C Y N 378 
TYR CE1  C Y N 379 
TYR CE2  C Y N 380 
TYR CZ   C Y N 381 
TYR OH   O N N 382 
TYR OXT  O N N 383 
TYR H    H N N 384 
TYR H2   H N N 385 
TYR HA   H N N 386 
TYR HB2  H N N 387 
TYR HB3  H N N 388 
TYR HD1  H N N 389 
TYR HD2  H N N 390 
TYR HE1  H N N 391 
TYR HE2  H N N 392 
TYR HH   H N N 393 
TYR HXT  H N N 394 
VAL N    N N N 395 
VAL CA   C N S 396 
VAL C    C N N 397 
VAL O    O N N 398 
VAL CB   C N N 399 
VAL CG1  C N N 400 
VAL CG2  C N N 401 
VAL OXT  O N N 402 
VAL H    H N N 403 
VAL H2   H N N 404 
VAL HA   H N N 405 
VAL HB   H N N 406 
VAL HG11 H N N 407 
VAL HG12 H N N 408 
VAL HG13 H N N 409 
VAL HG21 H N N 410 
VAL HG22 H N N 411 
VAL HG23 H N N 412 
VAL HXT  H N N 413 
X2Y C5   C N S 414 
X2Y C4   C N S 415 
X2Y C3   C N R 416 
X2Y C2   C N S 417 
X2Y C1   C N R 418 
X2Y O5   O N N 419 
X2Y C6   C N N 420 
X2Y O3   O N N 421 
X2Y S1   S N N 422 
X2Y O6   O N N 423 
X2Y O7   O N N 424 
X2Y O8   O N N 425 
X2Y O2   O N N 426 
X2Y S2   S N N 427 
X2Y O9   O N N 428 
X2Y O10  O N N 429 
X2Y O11  O N N 430 
X2Y O4   O N N 431 
X2Y H5   H N N 432 
X2Y H4   H N N 433 
X2Y H3   H N N 434 
X2Y H2   H N N 435 
X2Y H1   H N N 436 
X2Y H61  H N N 437 
X2Y H63  H N N 438 
X2Y H62  H N N 439 
X2Y HO3  H N N 440 
X2Y O1   O N N 441 
X2Y H9   H N N 442 
X2Y H11  H N N 443 
X2Y HO1  H N N 444 
X6Y C5   C N S 445 
X6Y C6   C N N 446 
X6Y C2   C N S 447 
X6Y C4   C N S 448 
X6Y C3   C N R 449 
X6Y C1   C N R 450 
X6Y O5   O N N 451 
X6Y O4   O N N 452 
X6Y O1   O N N 453 
X6Y O3   O N N 454 
X6Y S1   S N N 455 
X6Y O6   O N N 456 
X6Y O7   O N N 457 
X6Y O8   O N N 458 
X6Y O2   O N N 459 
X6Y H5   H N N 460 
X6Y H61  H N N 461 
X6Y H63  H N N 462 
X6Y H62  H N N 463 
X6Y H2   H N N 464 
X6Y H4   H N N 465 
X6Y H3   H N N 466 
X6Y H1   H N N 467 
X6Y HO4  H N N 468 
X6Y HO1  H N N 469 
X6Y HO3  H N N 470 
X6Y H10  H N N 471 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
FUC C1  C2   sing N N 83  
FUC C1  O1   sing N N 84  
FUC C1  O5   sing N N 85  
FUC C1  H1   sing N N 86  
FUC C2  C3   sing N N 87  
FUC C2  O2   sing N N 88  
FUC C2  H2   sing N N 89  
FUC C3  C4   sing N N 90  
FUC C3  O3   sing N N 91  
FUC C3  H3   sing N N 92  
FUC C4  C5   sing N N 93  
FUC C4  O4   sing N N 94  
FUC C4  H4   sing N N 95  
FUC C5  C6   sing N N 96  
FUC C5  O5   sing N N 97  
FUC C5  H5   sing N N 98  
FUC C6  H61  sing N N 99  
FUC C6  H62  sing N N 100 
FUC C6  H63  sing N N 101 
FUC O1  HO1  sing N N 102 
FUC O2  HO2  sing N N 103 
FUC O3  HO3  sing N N 104 
FUC O4  HO4  sing N N 105 
GLN N   CA   sing N N 106 
GLN N   H    sing N N 107 
GLN N   H2   sing N N 108 
GLN CA  C    sing N N 109 
GLN CA  CB   sing N N 110 
GLN CA  HA   sing N N 111 
GLN C   O    doub N N 112 
GLN C   OXT  sing N N 113 
GLN CB  CG   sing N N 114 
GLN CB  HB2  sing N N 115 
GLN CB  HB3  sing N N 116 
GLN CG  CD   sing N N 117 
GLN CG  HG2  sing N N 118 
GLN CG  HG3  sing N N 119 
GLN CD  OE1  doub N N 120 
GLN CD  NE2  sing N N 121 
GLN NE2 HE21 sing N N 122 
GLN NE2 HE22 sing N N 123 
GLN OXT HXT  sing N N 124 
GLU N   CA   sing N N 125 
GLU N   H    sing N N 126 
GLU N   H2   sing N N 127 
GLU CA  C    sing N N 128 
GLU CA  CB   sing N N 129 
GLU CA  HA   sing N N 130 
GLU C   O    doub N N 131 
GLU C   OXT  sing N N 132 
GLU CB  CG   sing N N 133 
GLU CB  HB2  sing N N 134 
GLU CB  HB3  sing N N 135 
GLU CG  CD   sing N N 136 
GLU CG  HG2  sing N N 137 
GLU CG  HG3  sing N N 138 
GLU CD  OE1  doub N N 139 
GLU CD  OE2  sing N N 140 
GLU OE2 HE2  sing N N 141 
GLU OXT HXT  sing N N 142 
GLY N   CA   sing N N 143 
GLY N   H    sing N N 144 
GLY N   H2   sing N N 145 
GLY CA  C    sing N N 146 
GLY CA  HA2  sing N N 147 
GLY CA  HA3  sing N N 148 
GLY C   O    doub N N 149 
GLY C   OXT  sing N N 150 
GLY OXT HXT  sing N N 151 
HIS N   CA   sing N N 152 
HIS N   H    sing N N 153 
HIS N   H2   sing N N 154 
HIS CA  C    sing N N 155 
HIS CA  CB   sing N N 156 
HIS CA  HA   sing N N 157 
HIS C   O    doub N N 158 
HIS C   OXT  sing N N 159 
HIS CB  CG   sing N N 160 
HIS CB  HB2  sing N N 161 
HIS CB  HB3  sing N N 162 
HIS CG  ND1  sing Y N 163 
HIS CG  CD2  doub Y N 164 
HIS ND1 CE1  doub Y N 165 
HIS ND1 HD1  sing N N 166 
HIS CD2 NE2  sing Y N 167 
HIS CD2 HD2  sing N N 168 
HIS CE1 NE2  sing Y N 169 
HIS CE1 HE1  sing N N 170 
HIS NE2 HE2  sing N N 171 
HIS OXT HXT  sing N N 172 
HOH O   H1   sing N N 173 
HOH O   H2   sing N N 174 
ILE N   CA   sing N N 175 
ILE N   H    sing N N 176 
ILE N   H2   sing N N 177 
ILE CA  C    sing N N 178 
ILE CA  CB   sing N N 179 
ILE CA  HA   sing N N 180 
ILE C   O    doub N N 181 
ILE C   OXT  sing N N 182 
ILE CB  CG1  sing N N 183 
ILE CB  CG2  sing N N 184 
ILE CB  HB   sing N N 185 
ILE CG1 CD1  sing N N 186 
ILE CG1 HG12 sing N N 187 
ILE CG1 HG13 sing N N 188 
ILE CG2 HG21 sing N N 189 
ILE CG2 HG22 sing N N 190 
ILE CG2 HG23 sing N N 191 
ILE CD1 HD11 sing N N 192 
ILE CD1 HD12 sing N N 193 
ILE CD1 HD13 sing N N 194 
ILE OXT HXT  sing N N 195 
LEU N   CA   sing N N 196 
LEU N   H    sing N N 197 
LEU N   H2   sing N N 198 
LEU CA  C    sing N N 199 
LEU CA  CB   sing N N 200 
LEU CA  HA   sing N N 201 
LEU C   O    doub N N 202 
LEU C   OXT  sing N N 203 
LEU CB  CG   sing N N 204 
LEU CB  HB2  sing N N 205 
LEU CB  HB3  sing N N 206 
LEU CG  CD1  sing N N 207 
LEU CG  CD2  sing N N 208 
LEU CG  HG   sing N N 209 
LEU CD1 HD11 sing N N 210 
LEU CD1 HD12 sing N N 211 
LEU CD1 HD13 sing N N 212 
LEU CD2 HD21 sing N N 213 
LEU CD2 HD22 sing N N 214 
LEU CD2 HD23 sing N N 215 
LEU OXT HXT  sing N N 216 
LYS N   CA   sing N N 217 
LYS N   H    sing N N 218 
LYS N   H2   sing N N 219 
LYS CA  C    sing N N 220 
LYS CA  CB   sing N N 221 
LYS CA  HA   sing N N 222 
LYS C   O    doub N N 223 
LYS C   OXT  sing N N 224 
LYS CB  CG   sing N N 225 
LYS CB  HB2  sing N N 226 
LYS CB  HB3  sing N N 227 
LYS CG  CD   sing N N 228 
LYS CG  HG2  sing N N 229 
LYS CG  HG3  sing N N 230 
LYS CD  CE   sing N N 231 
LYS CD  HD2  sing N N 232 
LYS CD  HD3  sing N N 233 
LYS CE  NZ   sing N N 234 
LYS CE  HE2  sing N N 235 
LYS CE  HE3  sing N N 236 
LYS NZ  HZ1  sing N N 237 
LYS NZ  HZ2  sing N N 238 
LYS NZ  HZ3  sing N N 239 
LYS OXT HXT  sing N N 240 
MET N   CA   sing N N 241 
MET N   H    sing N N 242 
MET N   H2   sing N N 243 
MET CA  C    sing N N 244 
MET CA  CB   sing N N 245 
MET CA  HA   sing N N 246 
MET C   O    doub N N 247 
MET C   OXT  sing N N 248 
MET CB  CG   sing N N 249 
MET CB  HB2  sing N N 250 
MET CB  HB3  sing N N 251 
MET CG  SD   sing N N 252 
MET CG  HG2  sing N N 253 
MET CG  HG3  sing N N 254 
MET SD  CE   sing N N 255 
MET CE  HE1  sing N N 256 
MET CE  HE2  sing N N 257 
MET CE  HE3  sing N N 258 
MET OXT HXT  sing N N 259 
PHE N   CA   sing N N 260 
PHE N   H    sing N N 261 
PHE N   H2   sing N N 262 
PHE CA  C    sing N N 263 
PHE CA  CB   sing N N 264 
PHE CA  HA   sing N N 265 
PHE C   O    doub N N 266 
PHE C   OXT  sing N N 267 
PHE CB  CG   sing N N 268 
PHE CB  HB2  sing N N 269 
PHE CB  HB3  sing N N 270 
PHE CG  CD1  doub Y N 271 
PHE CG  CD2  sing Y N 272 
PHE CD1 CE1  sing Y N 273 
PHE CD1 HD1  sing N N 274 
PHE CD2 CE2  doub Y N 275 
PHE CD2 HD2  sing N N 276 
PHE CE1 CZ   doub Y N 277 
PHE CE1 HE1  sing N N 278 
PHE CE2 CZ   sing Y N 279 
PHE CE2 HE2  sing N N 280 
PHE CZ  HZ   sing N N 281 
PHE OXT HXT  sing N N 282 
PRO N   CA   sing N N 283 
PRO N   CD   sing N N 284 
PRO N   H    sing N N 285 
PRO CA  C    sing N N 286 
PRO CA  CB   sing N N 287 
PRO CA  HA   sing N N 288 
PRO C   O    doub N N 289 
PRO C   OXT  sing N N 290 
PRO CB  CG   sing N N 291 
PRO CB  HB2  sing N N 292 
PRO CB  HB3  sing N N 293 
PRO CG  CD   sing N N 294 
PRO CG  HG2  sing N N 295 
PRO CG  HG3  sing N N 296 
PRO CD  HD2  sing N N 297 
PRO CD  HD3  sing N N 298 
PRO OXT HXT  sing N N 299 
SER N   CA   sing N N 300 
SER N   H    sing N N 301 
SER N   H2   sing N N 302 
SER CA  C    sing N N 303 
SER CA  CB   sing N N 304 
SER CA  HA   sing N N 305 
SER C   O    doub N N 306 
SER C   OXT  sing N N 307 
SER CB  OG   sing N N 308 
SER CB  HB2  sing N N 309 
SER CB  HB3  sing N N 310 
SER OG  HG   sing N N 311 
SER OXT HXT  sing N N 312 
THR N   CA   sing N N 313 
THR N   H    sing N N 314 
THR N   H2   sing N N 315 
THR CA  C    sing N N 316 
THR CA  CB   sing N N 317 
THR CA  HA   sing N N 318 
THR C   O    doub N N 319 
THR C   OXT  sing N N 320 
THR CB  OG1  sing N N 321 
THR CB  CG2  sing N N 322 
THR CB  HB   sing N N 323 
THR OG1 HG1  sing N N 324 
THR CG2 HG21 sing N N 325 
THR CG2 HG22 sing N N 326 
THR CG2 HG23 sing N N 327 
THR OXT HXT  sing N N 328 
TRP N   CA   sing N N 329 
TRP N   H    sing N N 330 
TRP N   H2   sing N N 331 
TRP CA  C    sing N N 332 
TRP CA  CB   sing N N 333 
TRP CA  HA   sing N N 334 
TRP C   O    doub N N 335 
TRP C   OXT  sing N N 336 
TRP CB  CG   sing N N 337 
TRP CB  HB2  sing N N 338 
TRP CB  HB3  sing N N 339 
TRP CG  CD1  doub Y N 340 
TRP CG  CD2  sing Y N 341 
TRP CD1 NE1  sing Y N 342 
TRP CD1 HD1  sing N N 343 
TRP CD2 CE2  doub Y N 344 
TRP CD2 CE3  sing Y N 345 
TRP NE1 CE2  sing Y N 346 
TRP NE1 HE1  sing N N 347 
TRP CE2 CZ2  sing Y N 348 
TRP CE3 CZ3  doub Y N 349 
TRP CE3 HE3  sing N N 350 
TRP CZ2 CH2  doub Y N 351 
TRP CZ2 HZ2  sing N N 352 
TRP CZ3 CH2  sing Y N 353 
TRP CZ3 HZ3  sing N N 354 
TRP CH2 HH2  sing N N 355 
TRP OXT HXT  sing N N 356 
TYR N   CA   sing N N 357 
TYR N   H    sing N N 358 
TYR N   H2   sing N N 359 
TYR CA  C    sing N N 360 
TYR CA  CB   sing N N 361 
TYR CA  HA   sing N N 362 
TYR C   O    doub N N 363 
TYR C   OXT  sing N N 364 
TYR CB  CG   sing N N 365 
TYR CB  HB2  sing N N 366 
TYR CB  HB3  sing N N 367 
TYR CG  CD1  doub Y N 368 
TYR CG  CD2  sing Y N 369 
TYR CD1 CE1  sing Y N 370 
TYR CD1 HD1  sing N N 371 
TYR CD2 CE2  doub Y N 372 
TYR CD2 HD2  sing N N 373 
TYR CE1 CZ   doub Y N 374 
TYR CE1 HE1  sing N N 375 
TYR CE2 CZ   sing Y N 376 
TYR CE2 HE2  sing N N 377 
TYR CZ  OH   sing N N 378 
TYR OH  HH   sing N N 379 
TYR OXT HXT  sing N N 380 
VAL N   CA   sing N N 381 
VAL N   H    sing N N 382 
VAL N   H2   sing N N 383 
VAL CA  C    sing N N 384 
VAL CA  CB   sing N N 385 
VAL CA  HA   sing N N 386 
VAL C   O    doub N N 387 
VAL C   OXT  sing N N 388 
VAL CB  CG1  sing N N 389 
VAL CB  CG2  sing N N 390 
VAL CB  HB   sing N N 391 
VAL CG1 HG11 sing N N 392 
VAL CG1 HG12 sing N N 393 
VAL CG1 HG13 sing N N 394 
VAL CG2 HG21 sing N N 395 
VAL CG2 HG22 sing N N 396 
VAL CG2 HG23 sing N N 397 
VAL OXT HXT  sing N N 398 
X2Y O7  S1   doub N N 399 
X2Y O8  S1   doub N N 400 
X2Y O6  S1   sing N N 401 
X2Y S1  O2   sing N N 402 
X2Y O2  C2   sing N N 403 
X2Y C2  C1   sing N N 404 
X2Y C2  C3   sing N N 405 
X2Y C1  O5   sing N N 406 
X2Y O5  C5   sing N N 407 
X2Y O3  C3   sing N N 408 
X2Y C3  C4   sing N N 409 
X2Y O4  C4   sing N N 410 
X2Y O4  S2   sing N N 411 
X2Y C5  C4   sing N N 412 
X2Y C5  C6   sing N N 413 
X2Y O9  S2   doub N N 414 
X2Y O10 S2   doub N N 415 
X2Y S2  O11  sing N N 416 
X2Y C5  H5   sing N N 417 
X2Y C4  H4   sing N N 418 
X2Y C3  H3   sing N N 419 
X2Y C2  H2   sing N N 420 
X2Y C1  H1   sing N N 421 
X2Y C6  H61  sing N N 422 
X2Y C6  H63  sing N N 423 
X2Y C6  H62  sing N N 424 
X2Y O3  HO3  sing N N 425 
X2Y C1  O1   sing N N 426 
X2Y O6  H9   sing N N 427 
X2Y O11 H11  sing N N 428 
X2Y O1  HO1  sing N N 429 
X6Y O8  S1   doub N N 430 
X6Y O2  S1   sing N N 431 
X6Y O2  C2   sing N N 432 
X6Y S1  O6   doub N N 433 
X6Y S1  O7   sing N N 434 
X6Y O1  C1   sing N N 435 
X6Y O3  C3   sing N N 436 
X6Y C2  C3   sing N N 437 
X6Y C2  C1   sing N N 438 
X6Y C3  C4   sing N N 439 
X6Y C1  O5   sing N N 440 
X6Y C4  C5   sing N N 441 
X6Y C4  O4   sing N N 442 
X6Y O5  C5   sing N N 443 
X6Y C5  C6   sing N N 444 
X6Y C5  H5   sing N N 445 
X6Y C6  H61  sing N N 446 
X6Y C6  H63  sing N N 447 
X6Y C6  H62  sing N N 448 
X6Y C2  H2   sing N N 449 
X6Y C4  H4   sing N N 450 
X6Y C3  H3   sing N N 451 
X6Y C1  H1   sing N N 452 
X6Y O4  HO4  sing N N 453 
X6Y O1  HO1  sing N N 454 
X6Y O3  HO3  sing N N 455 
X6Y O7  H10  sing N N 456 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           U22A20542 
_pdbx_audit_support.ordinal                1 
# 
loop_
_pdbx_entity_branch_list.entity_id 
_pdbx_entity_branch_list.comp_id 
_pdbx_entity_branch_list.num 
_pdbx_entity_branch_list.hetero 
2 X6Y 1 n 
2 X6Y 2 n 
2 X2Y 3 n 
2 FUC 4 n 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'in silico model' 
_pdbx_initial_refinement_model.source_name      AlphaFold 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9JP2 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.006740 
_atom_sites.fract_transf_matrix[1][2]   0.003892 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.007783 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.023794 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . HIS A 1 40  ? -4.728  -13.282 12.571  1.00 50.19 ?  4   HIS A N   1 
ATOM   2    C CA  . HIS A 1 40  ? -3.321  -13.484 12.897  1.00 43.54 ?  4   HIS A CA  1 
ATOM   3    C C   . HIS A 1 40  ? -2.797  -14.831 12.399  1.00 35.76 ?  4   HIS A C   1 
ATOM   4    O O   . HIS A 1 40  ? -3.385  -15.878 12.679  1.00 36.59 ?  4   HIS A O   1 
ATOM   5    C CB  . HIS A 1 40  ? -3.112  -13.341 14.406  1.00 50.92 ?  4   HIS A CB  1 
ATOM   6    C CG  . HIS A 1 40  ? -2.649  -11.975 14.817  1.00 60.17 ?  4   HIS A CG  1 
ATOM   7    N ND1 . HIS A 1 40  ? -3.120  -11.334 15.943  1.00 62.92 ?  4   HIS A ND1 1 
ATOM   8    C CD2 . HIS A 1 40  ? -1.754  -11.129 14.250  1.00 56.84 ?  4   HIS A CD2 1 
ATOM   9    C CE1 . HIS A 1 40  ? -2.535  -10.152 16.052  1.00 63.92 ?  4   HIS A CE1 1 
ATOM   10   N NE2 . HIS A 1 40  ? -1.701  -10.004 15.037  1.00 61.56 ?  4   HIS A NE2 1 
ATOM   11   N N   . TYR A 1 41  ? -1.709  -14.793 11.627  1.00 31.84 ?  5   TYR A N   1 
ATOM   12   C CA  . TYR A 1 41  ? -1.089  -16.025 11.172  1.00 31.18 ?  5   TYR A CA  1 
ATOM   13   C C   . TYR A 1 41  ? -0.504  -16.761 12.360  1.00 29.64 ?  5   TYR A C   1 
ATOM   14   O O   . TYR A 1 41  ? -0.031  -16.147 13.322  1.00 27.04 ?  5   TYR A O   1 
ATOM   15   C CB  . TYR A 1 41  ? -0.011  -15.743 10.127  1.00 29.17 ?  5   TYR A CB  1 
ATOM   16   C CG  . TYR A 1 41  ? -0.598  -15.261 8.824   1.00 31.79 ?  5   TYR A CG  1 
ATOM   17   C CD1 . TYR A 1 41  ? -1.088  -16.157 7.884   1.00 27.08 ?  5   TYR A CD1 1 
ATOM   18   C CD2 . TYR A 1 41  ? -0.706  -13.902 8.558   1.00 32.31 ?  5   TYR A CD2 1 
ATOM   19   C CE1 . TYR A 1 41  ? -1.636  -15.707 6.690   1.00 29.71 ?  5   TYR A CE1 1 
ATOM   20   C CE2 . TYR A 1 41  ? -1.254  -13.445 7.379   1.00 33.74 ?  5   TYR A CE2 1 
ATOM   21   C CZ  . TYR A 1 41  ? -1.720  -14.344 6.453   1.00 30.04 ?  5   TYR A CZ  1 
ATOM   22   O OH  . TYR A 1 41  ? -2.274  -13.859 5.292   1.00 34.80 ?  5   TYR A OH  1 
ATOM   23   N N   . LEU A 1 42  ? -0.561  -18.092 12.294  1.00 24.03 ?  6   LEU A N   1 
ATOM   24   C CA  . LEU A 1 42  ? -0.268  -18.952 13.428  1.00 25.46 ?  6   LEU A CA  1 
ATOM   25   C C   . LEU A 1 42  ? 0.911   -19.852 13.094  1.00 26.24 ?  6   LEU A C   1 
ATOM   26   O O   . LEU A 1 42  ? 0.874   -20.593 12.106  1.00 24.72 ?  6   LEU A O   1 
ATOM   27   C CB  . LEU A 1 42  ? -1.494  -19.793 13.801  1.00 31.03 ?  6   LEU A CB  1 
ATOM   28   C CG  . LEU A 1 42  ? -2.608  -19.020 14.512  1.00 35.07 ?  6   LEU A CG  1 
ATOM   29   C CD1 . LEU A 1 42  ? -3.833  -19.909 14.716  1.00 34.64 ?  6   LEU A CD1 1 
ATOM   30   C CD2 . LEU A 1 42  ? -2.089  -18.461 15.841  1.00 32.46 ?  6   LEU A CD2 1 
ATOM   31   N N   . ASN A 1 43  ? 1.950   -19.791 13.914  1.00 23.43 ?  7   ASN A N   1 
ATOM   32   C CA  . ASN A 1 43  ? 3.030   -20.750 13.778  1.00 27.52 ?  7   ASN A CA  1 
ATOM   33   C C   . ASN A 1 43  ? 2.514   -22.136 14.123  1.00 28.50 ?  7   ASN A C   1 
ATOM   34   O O   . ASN A 1 43  ? 1.435   -22.292 14.698  1.00 30.52 ?  7   ASN A O   1 
ATOM   35   C CB  . ASN A 1 43  ? 4.204   -20.376 14.680  1.00 29.12 ?  7   ASN A CB  1 
ATOM   36   C CG  . ASN A 1 43  ? 4.694   -18.969 14.429  1.00 25.46 ?  7   ASN A CG  1 
ATOM   37   O OD1 . ASN A 1 43  ? 4.903   -18.578 13.288  1.00 25.61 ?  7   ASN A OD1 1 
ATOM   38   N ND2 . ASN A 1 43  ? 4.866   -18.200 15.492  1.00 24.04 ?  7   ASN A ND2 1 
ATOM   39   N N   . SER A 1 44  ? 3.291   -23.157 13.761  1.00 30.46 ?  8   SER A N   1 
ATOM   40   C CA  . SER A 1 44  ? 2.795   -24.517 13.941  1.00 28.77 ?  8   SER A CA  1 
ATOM   41   C C   . SER A 1 44  ? 2.700   -24.930 15.406  1.00 34.45 ?  8   SER A C   1 
ATOM   42   O O   . SER A 1 44  ? 2.088   -25.963 15.690  1.00 33.54 ?  8   SER A O   1 
ATOM   43   C CB  . SER A 1 44  ? 3.672   -25.506 13.178  1.00 27.47 ?  8   SER A CB  1 
ATOM   44   O OG  . SER A 1 44  ? 4.922   -25.644 13.815  1.00 26.13 ?  8   SER A OG  1 
ATOM   45   N N   . ASP A 1 45  ? 3.279   -24.168 16.342  1.00 34.50 ?  9   ASP A N   1 
ATOM   46   C CA  . ASP A 1 45  ? 3.058   -24.427 17.760  1.00 30.55 ?  9   ASP A CA  1 
ATOM   47   C C   . ASP A 1 45  ? 1.813   -23.714 18.295  1.00 35.68 ?  9   ASP A C   1 
ATOM   48   O O   . ASP A 1 45  ? 1.564   -23.739 19.505  1.00 35.30 ?  9   ASP A O   1 
ATOM   49   C CB  . ASP A 1 45  ? 4.290   -24.026 18.577  1.00 28.40 ?  9   ASP A CB  1 
ATOM   50   C CG  . ASP A 1 45  ? 4.577   -22.539 18.528  1.00 30.78 ?  9   ASP A CG  1 
ATOM   51   O OD1 . ASP A 1 45  ? 3.915   -21.823 17.757  1.00 33.99 ?  9   ASP A OD1 1 
ATOM   52   O OD2 . ASP A 1 45  ? 5.474   -22.075 19.260  1.00 31.42 ?  9   ASP A OD2 1 
ATOM   53   N N   . GLY A 1 46  ? 1.038   -23.068 17.422  1.00 32.15 ?  10  GLY A N   1 
ATOM   54   C CA  . GLY A 1 46  ? -0.081  -22.256 17.842  1.00 34.07 ?  10  GLY A CA  1 
ATOM   55   C C   . GLY A 1 46  ? 0.249   -20.835 18.249  1.00 33.55 ?  10  GLY A C   1 
ATOM   56   O O   . GLY A 1 46  ? -0.683  -20.035 18.441  1.00 33.63 ?  10  GLY A O   1 
ATOM   57   N N   . SER A 1 47  ? 1.527   -20.489 18.416  1.00 31.37 ?  11  SER A N   1 
ATOM   58   C CA  . SER A 1 47  ? 1.867   -19.104 18.713  1.00 30.60 ?  11  SER A CA  1 
ATOM   59   C C   . SER A 1 47  ? 1.618   -18.244 17.481  1.00 31.86 ?  11  SER A C   1 
ATOM   60   O O   . SER A 1 47  ? 1.630   -18.725 16.344  1.00 30.51 ?  11  SER A O   1 
ATOM   61   C CB  . SER A 1 47  ? 3.322   -18.976 19.164  1.00 33.61 ?  11  SER A CB  1 
ATOM   62   O OG  . SER A 1 47  ? 4.210   -19.062 18.058  1.00 29.15 ?  11  SER A OG  1 
ATOM   63   N N   . ARG A 1 48  ? 1.370   -16.965 17.709  1.00 31.24 ?  12  ARG A N   1 
ATOM   64   C CA  . ARG A 1 48  ? 1.066   -16.066 16.612  1.00 32.18 ?  12  ARG A CA  1 
ATOM   65   C C   . ARG A 1 48  ? 2.352   -15.518 16.018  1.00 29.54 ?  12  ARG A C   1 
ATOM   66   O O   . ARG A 1 48  ? 3.352   -15.323 16.721  1.00 28.12 ?  12  ARG A O   1 
ATOM   67   C CB  . ARG A 1 48  ? 0.156   -14.932 17.083  1.00 38.23 ?  12  ARG A CB  1 
ATOM   68   C CG  . ARG A 1 48  ? 0.739   -14.110 18.208  1.00 47.72 ?  12  ARG A CG  1 
ATOM   69   C CD  . ARG A 1 48  ? 0.080   -12.731 18.265  1.00 53.17 ?  12  ARG A CD  1 
ATOM   70   N NE  . ARG A 1 48  ? -1.373  -12.841 18.304  1.00 59.97 ?  12  ARG A NE  1 
ATOM   71   C CZ  . ARG A 1 48  ? -2.067  -13.366 19.308  1.00 62.94 ?  12  ARG A CZ  1 
ATOM   72   N NH1 . ARG A 1 48  ? -1.474  -13.792 20.415  1.00 58.86 ?  12  ARG A NH1 1 
ATOM   73   N NH2 . ARG A 1 48  ? -3.393  -13.455 19.205  1.00 58.51 ?  12  ARG A NH2 1 
ATOM   74   N N   . PHE A 1 49  ? 2.334   -15.315 14.711  1.00 26.89 ?  13  PHE A N   1 
ATOM   75   C CA  . PHE A 1 49  ? 3.429   -14.661 14.009  1.00 28.18 ?  13  PHE A CA  1 
ATOM   76   C C   . PHE A 1 49  ? 3.036   -13.211 13.766  1.00 27.72 ?  13  PHE A C   1 
ATOM   77   O O   . PHE A 1 49  ? 1.999   -12.941 13.154  1.00 26.16 ?  13  PHE A O   1 
ATOM   78   C CB  . PHE A 1 49  ? 3.736   -15.371 12.691  1.00 24.20 ?  13  PHE A CB  1 
ATOM   79   C CG  . PHE A 1 49  ? 4.985   -14.885 12.025  1.00 26.69 ?  13  PHE A CG  1 
ATOM   80   C CD1 . PHE A 1 49  ? 4.998   -13.685 11.338  1.00 22.94 ?  13  PHE A CD1 1 
ATOM   81   C CD2 . PHE A 1 49  ? 6.157   -15.624 12.100  1.00 23.52 ?  13  PHE A CD2 1 
ATOM   82   C CE1 . PHE A 1 49  ? 6.161   -13.240 10.722  1.00 23.79 ?  13  PHE A CE1 1 
ATOM   83   C CE2 . PHE A 1 49  ? 7.318   -15.177 11.485  1.00 21.16 ?  13  PHE A CE2 1 
ATOM   84   C CZ  . PHE A 1 49  ? 7.308   -13.984 10.798  1.00 19.93 ?  13  PHE A CZ  1 
ATOM   85   N N   . VAL A 1 50  ? 3.843   -12.283 14.268  1.00 27.45 ?  14  VAL A N   1 
ATOM   86   C CA  . VAL A 1 50  ? 3.617   -10.860 14.048  1.00 29.75 ?  14  VAL A CA  1 
ATOM   87   C C   . VAL A 1 50  ? 4.727   -10.370 13.124  1.00 28.30 ?  14  VAL A C   1 
ATOM   88   O O   . VAL A 1 50  ? 5.893   -10.308 13.540  1.00 31.14 ?  14  VAL A O   1 
ATOM   89   C CB  . VAL A 1 50  ? 3.593   -10.067 15.362  1.00 32.25 ?  14  VAL A CB  1 
ATOM   90   C CG1 . VAL A 1 50  ? 3.190   -8.599  15.117  1.00 30.20 ?  14  VAL A CG1 1 
ATOM   91   C CG2 . VAL A 1 50  ? 2.676   -10.742 16.374  1.00 33.60 ?  14  VAL A CG2 1 
ATOM   92   N N   . PRO A 1 51  ? 4.424   -10.054 11.871  1.00 30.05 ?  15  PRO A N   1 
ATOM   93   C CA  . PRO A 1 51  ? 5.459   -9.604  10.937  1.00 26.11 ?  15  PRO A CA  1 
ATOM   94   C C   . PRO A 1 51  ? 5.847   -8.157  11.176  1.00 29.68 ?  15  PRO A C   1 
ATOM   95   O O   . PRO A 1 51  ? 5.061   -7.346  11.669  1.00 29.20 ?  15  PRO A O   1 
ATOM   96   C CB  . PRO A 1 51  ? 4.773   -9.750  9.575   1.00 27.16 ?  15  PRO A CB  1 
ATOM   97   C CG  . PRO A 1 51  ? 3.323   -9.442  9.888   1.00 28.35 ?  15  PRO A CG  1 
ATOM   98   C CD  . PRO A 1 51  ? 3.083   -10.060 11.258  1.00 28.49 ?  15  PRO A CD  1 
ATOM   99   N N   . LYS A 1 52  ? 7.073   -7.828  10.788  1.00 25.64 ?  16  LYS A N   1 
ATOM   100  C CA  . LYS A 1 52  ? 7.422   -6.422  10.754  1.00 26.70 ?  16  LYS A CA  1 
ATOM   101  C C   . LYS A 1 52  ? 6.713   -5.750  9.586   1.00 27.84 ?  16  LYS A C   1 
ATOM   102  O O   . LYS A 1 52  ? 6.320   -6.399  8.608   1.00 26.20 ?  16  LYS A O   1 
ATOM   103  C CB  . LYS A 1 52  ? 8.932   -6.229  10.638  1.00 27.66 ?  16  LYS A CB  1 
ATOM   104  C CG  . LYS A 1 52  ? 9.761   -7.125  11.546  1.00 29.92 ?  16  LYS A CG  1 
ATOM   105  C CD  . LYS A 1 52  ? 10.125  -6.422  12.842  1.00 34.02 ?  16  LYS A CD  1 
ATOM   106  C CE  . LYS A 1 52  ? 11.191  -7.197  13.600  1.00 32.67 ?  16  LYS A CE  1 
ATOM   107  N NZ  . LYS A 1 52  ? 12.559  -6.872  13.098  1.00 32.35 ?  16  LYS A NZ  1 
ATOM   108  N N   . ASP A 1 53  ? 6.569   -4.425  9.704   1.00 26.33 ?  17  ASP A N   1 
ATOM   109  C CA  . ASP A 1 53  ? 5.876   -3.603  8.717   1.00 31.24 ?  17  ASP A CA  1 
ATOM   110  C C   . ASP A 1 53  ? 6.441   -3.755  7.313   1.00 27.82 ?  17  ASP A C   1 
ATOM   111  O O   . ASP A 1 53  ? 5.719   -3.577  6.324   1.00 26.87 ?  17  ASP A O   1 
ATOM   112  C CB  . ASP A 1 53  ? 5.975   -2.129  9.131   1.00 39.32 ?  17  ASP A CB  1 
ATOM   113  C CG  . ASP A 1 53  ? 4.892   -1.722  10.108  1.00 51.41 ?  17  ASP A CG  1 
ATOM   114  O OD1 . ASP A 1 53  ? 4.263   -2.624  10.720  1.00 43.60 ?  17  ASP A OD1 1 
ATOM   115  O OD2 . ASP A 1 53  ? 4.675   -0.493  10.263  1.00 56.53 ?  17  ASP A OD2 1 
ATOM   116  N N   . PHE A 1 54  ? 7.734   -4.029  7.199   1.00 26.77 ?  18  PHE A N   1 
ATOM   117  C CA  . PHE A 1 54  ? 8.424   -4.018  5.915   1.00 30.09 ?  18  PHE A CA  1 
ATOM   118  C C   . PHE A 1 54  ? 8.564   -5.410  5.306   1.00 23.57 ?  18  PHE A C   1 
ATOM   119  O O   . PHE A 1 54  ? 9.218   -5.555  4.268   1.00 26.31 ?  18  PHE A O   1 
ATOM   120  C CB  . PHE A 1 54  ? 9.804   -3.372  6.078   1.00 27.39 ?  18  PHE A CB  1 
ATOM   121  C CG  . PHE A 1 54  ? 10.672  -4.058  7.093   1.00 29.18 ?  18  PHE A CG  1 
ATOM   122  C CD1 . PHE A 1 54  ? 11.488  -5.121  6.722   1.00 28.55 ?  18  PHE A CD1 1 
ATOM   123  C CD2 . PHE A 1 54  ? 10.671  -3.653  8.420   1.00 28.40 ?  18  PHE A CD2 1 
ATOM   124  C CE1 . PHE A 1 54  ? 12.282  -5.767  7.654   1.00 26.51 ?  18  PHE A CE1 1 
ATOM   125  C CE2 . PHE A 1 54  ? 11.466  -4.299  9.364   1.00 28.45 ?  18  PHE A CE2 1 
ATOM   126  C CZ  . PHE A 1 54  ? 12.271  -5.359  8.984   1.00 26.00 ?  18  PHE A CZ  1 
ATOM   127  N N   . TYR A 1 55  ? 7.968   -6.430  5.921   1.00 24.27 ?  19  TYR A N   1 
ATOM   128  C CA  . TYR A 1 55  ? 8.034   -7.774  5.371   1.00 24.73 ?  19  TYR A CA  1 
ATOM   129  C C   . TYR A 1 55  ? 7.194   -7.850  4.103   1.00 23.73 ?  19  TYR A C   1 
ATOM   130  O O   . TYR A 1 55  ? 6.238   -7.091  3.945   1.00 20.26 ?  19  TYR A O   1 
ATOM   131  C CB  . TYR A 1 55  ? 7.504   -8.796  6.367   1.00 26.43 ?  19  TYR A CB  1 
ATOM   132  C CG  . TYR A 1 55  ? 8.490   -9.254  7.415   1.00 24.91 ?  19  TYR A CG  1 
ATOM   133  C CD1 . TYR A 1 55  ? 9.664   -8.547  7.665   1.00 25.90 ?  19  TYR A CD1 1 
ATOM   134  C CD2 . TYR A 1 55  ? 8.241   -10.407 8.155   1.00 21.90 ?  19  TYR A CD2 1 
ATOM   135  C CE1 . TYR A 1 55  ? 10.557  -8.976  8.644   1.00 26.50 ?  19  TYR A CE1 1 
ATOM   136  C CE2 . TYR A 1 55  ? 9.110   -10.834 9.113   1.00 25.52 ?  19  TYR A CE2 1 
ATOM   137  C CZ  . TYR A 1 55  ? 10.265  -10.122 9.356   1.00 22.97 ?  19  TYR A CZ  1 
ATOM   138  O OH  . TYR A 1 55  ? 11.114  -10.574 10.328  1.00 29.30 ?  19  TYR A OH  1 
ATOM   139  N N   . PRO A 1 56  ? 7.524   -8.765  3.193   1.00 22.13 ?  20  PRO A N   1 
ATOM   140  C CA  . PRO A 1 56  ? 6.680   -8.976  2.018   1.00 23.28 ?  20  PRO A CA  1 
ATOM   141  C C   . PRO A 1 56  ? 5.309   -9.474  2.441   1.00 24.64 ?  20  PRO A C   1 
ATOM   142  O O   . PRO A 1 56  ? 5.079   -9.847  3.596   1.00 21.90 ?  20  PRO A O   1 
ATOM   143  C CB  . PRO A 1 56  ? 7.451   -10.034 1.226   1.00 24.89 ?  20  PRO A CB  1 
ATOM   144  C CG  . PRO A 1 56  ? 8.221   -10.761 2.255   1.00 26.21 ?  20  PRO A CG  1 
ATOM   145  C CD  . PRO A 1 56  ? 8.650   -9.710  3.224   1.00 22.16 ?  20  PRO A CD  1 
ATOM   146  N N   . LYS A 1 57  ? 4.372   -9.444  1.501   1.00 24.04 ?  21  LYS A N   1 
ATOM   147  C CA  . LYS A 1 57  ? 3.072   -10.006 1.823   1.00 26.82 ?  21  LYS A CA  1 
ATOM   148  C C   . LYS A 1 57  ? 3.199   -11.516 1.989   1.00 26.20 ?  21  LYS A C   1 
ATOM   149  O O   . LYS A 1 57  ? 4.122   -12.153 1.472   1.00 22.00 ?  21  LYS A O   1 
ATOM   150  C CB  . LYS A 1 57  ? 2.031   -9.665  0.754   1.00 28.60 ?  21  LYS A CB  1 
ATOM   151  C CG  . LYS A 1 57  ? 1.942   -8.191  0.402   1.00 33.62 ?  21  LYS A CG  1 
ATOM   152  C CD  . LYS A 1 57  ? 1.883   -7.315  1.661   1.00 36.44 ?  21  LYS A CD  1 
ATOM   153  C CE  . LYS A 1 57  ? 2.578   -5.952  1.445   1.00 41.40 ?  21  LYS A CE  1 
ATOM   154  N NZ  . LYS A 1 57  ? 4.054   -5.924  1.714   1.00 40.79 ?  21  LYS A NZ  1 
ATOM   155  N N   . PHE A 1 58  ? 2.269   -12.082 2.750   1.00 25.99 ?  22  PHE A N   1 
ATOM   156  C CA  . PHE A 1 58  ? 2.192   -13.522 2.940   1.00 25.43 ?  22  PHE A CA  1 
ATOM   157  C C   . PHE A 1 58  ? 0.735   -13.941 2.909   1.00 26.74 ?  22  PHE A C   1 
ATOM   158  O O   . PHE A 1 58  ? -0.146  -13.176 3.287   1.00 23.12 ?  22  PHE A O   1 
ATOM   159  C CB  . PHE A 1 58  ? 2.798   -13.974 4.264   1.00 24.25 ?  22  PHE A CB  1 
ATOM   160  C CG  . PHE A 1 58  ? 2.666   -15.447 4.510   1.00 25.18 ?  22  PHE A CG  1 
ATOM   161  C CD1 . PHE A 1 58  ? 3.554   -16.338 3.929   1.00 26.39 ?  22  PHE A CD1 1 
ATOM   162  C CD2 . PHE A 1 58  ? 1.649   -15.943 5.304   1.00 23.48 ?  22  PHE A CD2 1 
ATOM   163  C CE1 . PHE A 1 58  ? 3.440   -17.684 4.152   1.00 22.51 ?  22  PHE A CE1 1 
ATOM   164  C CE2 . PHE A 1 58  ? 1.535   -17.307 5.526   1.00 22.95 ?  22  PHE A CE2 1 
ATOM   165  C CZ  . PHE A 1 58  ? 2.421   -18.167 4.945   1.00 24.44 ?  22  PHE A CZ  1 
ATOM   166  N N   . SER A 1 59  ? 0.497   -15.177 2.486   1.00 27.50 ?  23  SER A N   1 
ATOM   167  C CA  . SER A 1 59  ? -0.853  -15.705 2.389   1.00 29.84 ?  23  SER A CA  1 
ATOM   168  C C   . SER A 1 59  ? -0.762  -17.212 2.231   1.00 26.63 ?  23  SER A C   1 
ATOM   169  O O   . SER A 1 59  ? 0.164   -17.717 1.585   1.00 24.69 ?  23  SER A O   1 
ATOM   170  C CB  . SER A 1 59  ? -1.591  -15.079 1.195   1.00 30.10 ?  23  SER A CB  1 
ATOM   171  O OG  . SER A 1 59  ? -2.602  -15.940 0.732   1.00 28.34 ?  23  SER A OG  1 
ATOM   172  N N   . TRP A 1 60  ? -1.712  -17.925 2.827   1.00 25.52 ?  24  TRP A N   1 
ATOM   173  C CA  . TRP A 1 60  ? -1.814  -19.360 2.605   1.00 28.69 ?  24  TRP A CA  1 
ATOM   174  C C   . TRP A 1 60  ? -2.715  -19.717 1.420   1.00 28.13 ?  24  TRP A C   1 
ATOM   175  O O   . TRP A 1 60  ? -2.972  -20.905 1.199   1.00 25.31 ?  24  TRP A O   1 
ATOM   176  C CB  . TRP A 1 60  ? -2.336  -20.059 3.859   1.00 25.19 ?  24  TRP A CB  1 
ATOM   177  C CG  . TRP A 1 60  ? -1.426  -20.062 5.066   1.00 22.27 ?  24  TRP A CG  1 
ATOM   178  C CD1 . TRP A 1 60  ? -1.660  -19.435 6.251   1.00 25.54 ?  24  TRP A CD1 1 
ATOM   179  C CD2 . TRP A 1 60  ? -0.185  -20.770 5.228   1.00 24.71 ?  24  TRP A CD2 1 
ATOM   180  N NE1 . TRP A 1 60  ? -0.638  -19.682 7.136   1.00 26.13 ?  24  TRP A NE1 1 
ATOM   181  C CE2 . TRP A 1 60  ? 0.275   -20.507 6.537   1.00 27.30 ?  24  TRP A CE2 1 
ATOM   182  C CE3 . TRP A 1 60  ? 0.586   -21.587 4.395   1.00 25.73 ?  24  TRP A CE3 1 
ATOM   183  C CZ2 . TRP A 1 60  ? 1.467   -21.034 7.033   1.00 27.55 ?  24  TRP A CZ2 1 
ATOM   184  C CZ3 . TRP A 1 60  ? 1.774   -22.108 4.888   1.00 23.48 ?  24  TRP A CZ3 1 
ATOM   185  C CH2 . TRP A 1 60  ? 2.203   -21.824 6.195   1.00 24.71 ?  24  TRP A CH2 1 
ATOM   186  N N   . ASP A 1 61  ? -3.206  -18.726 0.665   1.00 25.32 ?  25  ASP A N   1 
ATOM   187  C CA  . ASP A 1 61  ? -4.150  -19.015 -0.420  1.00 30.73 ?  25  ASP A CA  1 
ATOM   188  C C   . ASP A 1 61  ? -3.624  -20.106 -1.340  1.00 26.49 ?  25  ASP A C   1 
ATOM   189  O O   . ASP A 1 61  ? -4.334  -21.068 -1.664  1.00 22.87 ?  25  ASP A O   1 
ATOM   190  C CB  . ASP A 1 61  ? -4.443  -17.746 -1.221  1.00 27.26 ?  25  ASP A CB  1 
ATOM   191  C CG  . ASP A 1 61  ? -5.267  -16.762 -0.444  1.00 28.64 ?  25  ASP A CG  1 
ATOM   192  O OD1 . ASP A 1 61  ? -5.777  -17.142 0.638   1.00 29.88 ?  25  ASP A OD1 1 
ATOM   193  O OD2 . ASP A 1 61  ? -5.398  -15.607 -0.908  1.00 36.75 ?  25  ASP A OD2 1 
ATOM   194  N N   . THR A 1 62  ? -2.385  -19.958 -1.781  1.00 26.51 ?  26  THR A N   1 
ATOM   195  C CA  . THR A 1 62  ? -1.660  -20.992 -2.503  1.00 27.54 ?  26  THR A CA  1 
ATOM   196  C C   . THR A 1 62  ? -0.277  -21.073 -1.881  1.00 26.33 ?  26  THR A C   1 
ATOM   197  O O   . THR A 1 62  ? 0.005   -20.396 -0.886  1.00 24.78 ?  26  THR A O   1 
ATOM   198  C CB  . THR A 1 62  ? -1.591  -20.689 -4.006  1.00 29.48 ?  26  THR A CB  1 
ATOM   199  O OG1 . THR A 1 62  ? -0.900  -19.452 -4.214  1.00 28.52 ?  26  THR A OG1 1 
ATOM   200  C CG2 . THR A 1 62  ? -2.991  -20.580 -4.585  1.00 30.32 ?  26  THR A CG2 1 
ATOM   201  N N   . THR A 1 63  ? 0.577   -21.913 -2.445  1.00 24.71 ?  27  THR A N   1 
ATOM   202  C CA  . THR A 1 63  ? 1.900   -22.107 -1.872  1.00 25.29 ?  27  THR A CA  1 
ATOM   203  C C   . THR A 1 63  ? 2.628   -20.763 -1.846  1.00 25.18 ?  27  THR A C   1 
ATOM   204  O O   . THR A 1 63  ? 2.749   -20.125 -2.891  1.00 22.48 ?  27  THR A O   1 
ATOM   205  C CB  . THR A 1 63  ? 2.702   -23.131 -2.667  1.00 24.49 ?  27  THR A CB  1 
ATOM   206  O OG1 . THR A 1 63  ? 2.061   -24.414 -2.608  1.00 30.07 ?  27  THR A OG1 1 
ATOM   207  C CG2 . THR A 1 63  ? 4.099   -23.260 -2.087  1.00 21.83 ?  27  THR A CG2 1 
ATOM   208  N N   . PRO A 1 64  ? 3.072   -20.283 -0.685  1.00 25.04 ?  28  PRO A N   1 
ATOM   209  C CA  . PRO A 1 64  ? 3.833   -19.020 -0.646  1.00 25.10 ?  28  PRO A CA  1 
ATOM   210  C C   . PRO A 1 64  ? 5.149   -19.181 -1.392  1.00 24.59 ?  28  PRO A C   1 
ATOM   211  O O   . PRO A 1 64  ? 5.929   -20.103 -1.119  1.00 23.34 ?  28  PRO A O   1 
ATOM   212  C CB  . PRO A 1 64  ? 4.057   -18.771 0.856   1.00 24.40 ?  28  PRO A CB  1 
ATOM   213  C CG  . PRO A 1 64  ? 3.315   -19.895 1.585   1.00 27.14 ?  28  PRO A CG  1 
ATOM   214  C CD  . PRO A 1 64  ? 3.061   -20.984 0.608   1.00 22.13 ?  28  PRO A CD  1 
ATOM   215  N N   . MET A 1 65  ? 5.394   -18.276 -2.335  1.00 23.04 ?  29  MET A N   1 
ATOM   216  C CA  . MET A 1 65  ? 6.444   -18.452 -3.321  1.00 23.40 ?  29  MET A CA  1 
ATOM   217  C C   . MET A 1 65  ? 7.501   -17.364 -3.156  1.00 24.14 ?  29  MET A C   1 
ATOM   218  O O   . MET A 1 65  ? 7.196   -16.215 -2.806  1.00 24.47 ?  29  MET A O   1 
ATOM   219  C CB  . MET A 1 65  ? 5.854   -18.386 -4.748  1.00 24.50 ?  29  MET A CB  1 
ATOM   220  C CG  . MET A 1 65  ? 5.228   -19.701 -5.248  1.00 25.86 ?  29  MET A CG  1 
ATOM   221  S SD  . MET A 1 65  ? 6.103   -21.231 -4.816  1.00 28.49 ?  29  MET A SD  1 
ATOM   222  C CE  . MET A 1 65  ? 7.414   -21.240 -6.013  1.00 25.52 ?  29  MET A CE  1 
ATOM   223  N N   . TYR A 1 66  ? 8.745   -17.749 -3.425  1.00 24.17 ?  30  TYR A N   1 
ATOM   224  C CA  . TYR A 1 66  ? 9.886   -16.848 -3.517  1.00 23.42 ?  30  TYR A CA  1 
ATOM   225  C C   . TYR A 1 66  ? 10.614  -17.207 -4.800  1.00 22.59 ?  30  TYR A C   1 
ATOM   226  O O   . TYR A 1 66  ? 10.847  -18.387 -5.066  1.00 22.88 ?  30  TYR A O   1 
ATOM   227  C CB  . TYR A 1 66  ? 10.805  -17.013 -2.293  1.00 19.06 ?  30  TYR A CB  1 
ATOM   228  C CG  . TYR A 1 66  ? 12.192  -16.355 -2.347  1.00 22.21 ?  30  TYR A CG  1 
ATOM   229  C CD1 . TYR A 1 66  ? 12.376  -15.029 -1.952  1.00 19.43 ?  30  TYR A CD1 1 
ATOM   230  C CD2 . TYR A 1 66  ? 13.318  -17.073 -2.758  1.00 20.54 ?  30  TYR A CD2 1 
ATOM   231  C CE1 . TYR A 1 66  ? 13.641  -14.435 -1.974  1.00 20.95 ?  30  TYR A CE1 1 
ATOM   232  C CE2 . TYR A 1 66  ? 14.592  -16.482 -2.782  1.00 19.69 ?  30  TYR A CE2 1 
ATOM   233  C CZ  . TYR A 1 66  ? 14.748  -15.172 -2.380  1.00 22.97 ?  30  TYR A CZ  1 
ATOM   234  O OH  . TYR A 1 66  ? 16.020  -14.585 -2.376  1.00 18.93 ?  30  TYR A OH  1 
ATOM   235  N N   . TYR A 1 67  ? 10.965  -16.215 -5.598  1.00 21.24 ?  31  TYR A N   1 
ATOM   236  C CA  . TYR A 1 67  ? 11.657  -16.474 -6.852  1.00 21.78 ?  31  TYR A CA  1 
ATOM   237  C C   . TYR A 1 67  ? 13.060  -15.885 -6.790  1.00 24.26 ?  31  TYR A C   1 
ATOM   238  O O   . TYR A 1 67  ? 13.287  -14.853 -6.157  1.00 22.09 ?  31  TYR A O   1 
ATOM   239  C CB  . TYR A 1 67  ? 10.873  -15.884 -8.037  1.00 21.37 ?  31  TYR A CB  1 
ATOM   240  C CG  . TYR A 1 67  ? 9.719   -16.762 -8.493  1.00 24.82 ?  31  TYR A CG  1 
ATOM   241  C CD1 . TYR A 1 67  ? 8.640   -17.032 -7.650  1.00 22.67 ?  31  TYR A CD1 1 
ATOM   242  C CD2 . TYR A 1 67  ? 9.710   -17.322 -9.765  1.00 27.09 ?  31  TYR A CD2 1 
ATOM   243  C CE1 . TYR A 1 67  ? 7.579   -17.853 -8.070  1.00 26.84 ?  31  TYR A CE1 1 
ATOM   244  C CE2 . TYR A 1 67  ? 8.655   -18.130 -10.197 1.00 27.72 ?  31  TYR A CE2 1 
ATOM   245  C CZ  . TYR A 1 67  ? 7.596   -18.396 -9.347  1.00 29.47 ?  31  TYR A CZ  1 
ATOM   246  O OH  . TYR A 1 67  ? 6.558   -19.205 -9.783  1.00 30.69 ?  31  TYR A OH  1 
ATOM   247  N N   . MET A 1 68  ? 14.031  -16.538 -7.407  1.00 21.53 ?  32  MET A N   1 
ATOM   248  C CA  . MET A 1 68  ? 15.395  -15.956 -7.494  1.00 23.60 ?  32  MET A CA  1 
ATOM   249  C C   . MET A 1 68  ? 15.960  -16.310 -8.863  1.00 25.96 ?  32  MET A C   1 
ATOM   250  O O   . MET A 1 68  ? 15.939  -17.487 -9.224  1.00 26.55 ?  32  MET A O   1 
ATOM   251  C CB  . MET A 1 68  ? 16.322  -16.478 -6.406  1.00 22.46 ?  32  MET A CB  1 
ATOM   252  C CG  . MET A 1 68  ? 17.529  -15.629 -6.153  1.00 24.67 ?  32  MET A CG  1 
ATOM   253  S SD  . MET A 1 68  ? 18.168  -16.065 -4.534  1.00 24.64 ?  32  MET A SD  1 
ATOM   254  C CE  . MET A 1 68  ? 19.835  -15.424 -4.663  1.00 23.26 ?  32  MET A CE  1 
ATOM   255  N N   . PHE A 1 69  ? 16.481  -15.321 -9.559  1.00 24.73 ?  33  PHE A N   1 
ATOM   256  C CA  . PHE A 1 69  ? 16.870  -15.574 -10.934 1.00 23.32 ?  33  PHE A CA  1 
ATOM   257  C C   . PHE A 1 69  ? 17.789  -14.459 -11.408 1.00 26.43 ?  33  PHE A C   1 
ATOM   258  O O   . PHE A 1 69  ? 17.865  -13.377 -10.814 1.00 22.64 ?  33  PHE A O   1 
ATOM   259  C CB  . PHE A 1 69  ? 15.631  -15.673 -11.824 1.00 25.46 ?  33  PHE A CB  1 
ATOM   260  C CG  . PHE A 1 69  ? 14.708  -14.507 -11.652 1.00 26.86 ?  33  PHE A CG  1 
ATOM   261  C CD1 . PHE A 1 69  ? 14.892  -13.356 -12.392 1.00 26.06 ?  33  PHE A CD1 1 
ATOM   262  C CD2 . PHE A 1 69  ? 13.699  -14.536 -10.699 1.00 29.29 ?  33  PHE A CD2 1 
ATOM   263  C CE1 . PHE A 1 69  ? 14.068  -12.263 -12.216 1.00 24.85 ?  33  PHE A CE1 1 
ATOM   264  C CE2 . PHE A 1 69  ? 12.858  -13.432 -10.509 1.00 25.52 ?  33  PHE A CE2 1 
ATOM   265  C CZ  . PHE A 1 69  ? 13.041  -12.299 -11.272 1.00 25.03 ?  33  PHE A CZ  1 
ATOM   266  N N   . GLY A 1 70  ? 18.484  -14.741 -12.492 1.00 25.34 ?  34  GLY A N   1 
ATOM   267  C CA  . GLY A 1 70  ? 19.262  -13.725 -13.157 1.00 24.64 ?  34  GLY A CA  1 
ATOM   268  C C   . GLY A 1 70  ? 19.764  -14.287 -14.459 1.00 26.99 ?  34  GLY A C   1 
ATOM   269  O O   . GLY A 1 70  ? 19.799  -15.504 -14.655 1.00 31.33 ?  34  GLY A O   1 
ATOM   270  N N   . ASP A 1 71  ? 20.136  -13.383 -15.357 1.00 28.97 ?  35  ASP A N   1 
ATOM   271  C CA  . ASP A 1 71  ? 20.654  -13.766 -16.666 1.00 26.73 ?  35  ASP A CA  1 
ATOM   272  C C   . ASP A 1 71  ? 21.738  -12.769 -17.036 1.00 25.76 ?  35  ASP A C   1 
ATOM   273  O O   . ASP A 1 71  ? 21.471  -11.570 -17.179 1.00 26.12 ?  35  ASP A O   1 
ATOM   274  C CB  . ASP A 1 71  ? 19.536  -13.790 -17.715 1.00 28.51 ?  35  ASP A CB  1 
ATOM   275  C CG  . ASP A 1 71  ? 19.902  -14.599 -18.944 1.00 34.95 ?  35  ASP A CG  1 
ATOM   276  O OD1 . ASP A 1 71  ? 21.080  -14.528 -19.381 1.00 35.85 ?  35  ASP A OD1 1 
ATOM   277  O OD2 . ASP A 1 71  ? 19.014  -15.301 -19.481 1.00 37.34 ?  35  ASP A OD2 1 
ATOM   278  N N   . THR A 1 72  ? 22.970  -13.257 -17.152 1.00 26.72 ?  36  THR A N   1 
ATOM   279  C CA  . THR A 1 72  ? 24.066  -12.367 -17.500 1.00 26.46 ?  36  THR A CA  1 
ATOM   280  C C   . THR A 1 72  ? 23.833  -11.701 -18.845 1.00 26.87 ?  36  THR A C   1 
ATOM   281  O O   . THR A 1 72  ? 24.270  -10.565 -19.058 1.00 33.18 ?  36  THR A O   1 
ATOM   282  C CB  . THR A 1 72  ? 25.372  -13.155 -17.498 1.00 30.96 ?  36  THR A CB  1 
ATOM   283  O OG1 . THR A 1 72  ? 25.419  -13.943 -16.302 1.00 32.00 ?  36  THR A OG1 1 
ATOM   284  C CG2 . THR A 1 72  ? 26.581  -12.208 -17.544 1.00 30.09 ?  36  THR A CG2 1 
ATOM   285  N N   . THR A 1 73  ? 23.079  -12.356 -19.726 1.00 24.11 ?  37  THR A N   1 
ATOM   286  C CA  . THR A 1 73  ? 22.999  -12.010 -21.136 1.00 25.02 ?  37  THR A CA  1 
ATOM   287  C C   . THR A 1 73  ? 21.868  -11.060 -21.487 1.00 32.35 ?  37  THR A C   1 
ATOM   288  O O   . THR A 1 73  ? 21.877  -10.500 -22.584 1.00 34.04 ?  37  THR A O   1 
ATOM   289  C CB  . THR A 1 73  ? 22.807  -13.274 -21.971 1.00 28.26 ?  37  THR A CB  1 
ATOM   290  O OG1 . THR A 1 73  ? 21.444  -13.716 -21.832 1.00 32.11 ?  37  THR A OG1 1 
ATOM   291  C CG2 . THR A 1 73  ? 23.744  -14.376 -21.499 1.00 33.84 ?  37  THR A CG2 1 
ATOM   292  N N   . ARG A 1 74  ? 20.867  -10.901 -20.630 1.00 31.16 ?  38  ARG A N   1 
ATOM   293  C CA  . ARG A 1 74  ? 19.711  -10.119 -21.027 1.00 30.86 ?  38  ARG A CA  1 
ATOM   294  C C   . ARG A 1 74  ? 18.914  -9.741  -19.791 1.00 29.52 ?  38  ARG A C   1 
ATOM   295  O O   . ARG A 1 74  ? 19.075  -10.320 -18.715 1.00 27.42 ?  38  ARG A O   1 
ATOM   296  C CB  . ARG A 1 74  ? 18.825  -10.881 -22.032 1.00 29.25 ?  38  ARG A CB  1 
ATOM   297  C CG  . ARG A 1 74  ? 18.211  -12.192 -21.499 1.00 30.92 ?  38  ARG A CG  1 
ATOM   298  C CD  . ARG A 1 74  ? 17.339  -12.882 -22.556 1.00 33.53 ?  38  ARG A CD  1 
ATOM   299  N NE  . ARG A 1 74  ? 16.548  -13.999 -22.042 1.00 31.74 ?  38  ARG A NE  1 
ATOM   300  C CZ  . ARG A 1 74  ? 15.373  -13.880 -21.428 1.00 34.25 ?  38  ARG A CZ  1 
ATOM   301  N NH1 . ARG A 1 74  ? 14.842  -12.692 -21.159 1.00 25.18 ?  38  ARG A NH1 1 
ATOM   302  N NH2 . ARG A 1 74  ? 14.713  -14.981 -21.068 1.00 31.25 ?  38  ARG A NH2 1 
ATOM   303  N N   . LEU A 1 75  ? 18.072  -8.741  -19.959 1.00 25.57 ?  39  LEU A N   1 
ATOM   304  C CA  . LEU A 1 75  ? 17.075  -8.401  -18.961 1.00 28.85 ?  39  LEU A CA  1 
ATOM   305  C C   . LEU A 1 75  ? 15.801  -9.179  -19.265 1.00 27.54 ?  39  LEU A C   1 
ATOM   306  O O   . LEU A 1 75  ? 15.669  -9.810  -20.318 1.00 25.03 ?  39  LEU A O   1 
ATOM   307  C CB  . LEU A 1 75  ? 16.823  -6.889  -18.950 1.00 28.66 ?  39  LEU A CB  1 
ATOM   308  C CG  . LEU A 1 75  ? 18.101  -6.059  -18.791 1.00 29.06 ?  39  LEU A CG  1 
ATOM   309  C CD1 . LEU A 1 75  ? 17.910  -4.642  -19.286 1.00 28.34 ?  39  LEU A CD1 1 
ATOM   310  C CD2 . LEU A 1 75  ? 18.542  -6.071  -17.335 1.00 26.90 ?  39  LEU A CD2 1 
ATOM   311  N N   . LEU A 1 76  ? 14.864  -9.148  -18.325 1.00 27.86 ?  40  LEU A N   1 
ATOM   312  C CA  . LEU A 1 76  ? 13.596  -9.837  -18.527 1.00 26.44 ?  40  LEU A CA  1 
ATOM   313  C C   . LEU A 1 76  ? 12.744  -9.094  -19.545 1.00 27.20 ?  40  LEU A C   1 
ATOM   314  O O   . LEU A 1 76  ? 12.702  -7.861  -19.551 1.00 28.24 ?  40  LEU A O   1 
ATOM   315  C CB  . LEU A 1 76  ? 12.835  -9.944  -17.207 1.00 26.33 ?  40  LEU A CB  1 
ATOM   316  C CG  . LEU A 1 76  ? 13.032  -11.212 -16.377 1.00 27.43 ?  40  LEU A CG  1 
ATOM   317  C CD1 . LEU A 1 76  ? 14.486  -11.382 -15.983 1.00 26.81 ?  40  LEU A CD1 1 
ATOM   318  C CD2 . LEU A 1 76  ? 12.146  -11.153 -15.146 1.00 24.89 ?  40  LEU A CD2 1 
ATOM   319  N N   . GLU A 1 77  ? 12.058  -9.848  -20.403 1.00 25.03 ?  41  GLU A N   1 
ATOM   320  C CA  . GLU A 1 77  ? 11.008  -9.273  -21.233 1.00 29.13 ?  41  GLU A CA  1 
ATOM   321  C C   . GLU A 1 77  ? 9.828   -8.856  -20.346 1.00 26.97 ?  41  GLU A C   1 
ATOM   322  O O   . GLU A 1 77  ? 9.634   -9.414  -19.267 1.00 30.12 ?  41  GLU A O   1 
ATOM   323  C CB  . GLU A 1 77  ? 10.532  -10.288 -22.275 1.00 28.86 ?  41  GLU A CB  1 
ATOM   324  C CG  . GLU A 1 77  ? 11.594  -10.748 -23.271 1.00 28.27 ?  41  GLU A CG  1 
ATOM   325  C CD  . GLU A 1 77  ? 12.167  -9.597  -24.068 1.00 32.91 ?  41  GLU A CD  1 
ATOM   326  O OE1 . GLU A 1 77  ? 11.421  -8.631  -24.329 1.00 34.25 ?  41  GLU A OE1 1 
ATOM   327  O OE2 . GLU A 1 77  ? 13.359  -9.655  -24.433 1.00 37.15 ?  41  GLU A OE2 1 
ATOM   328  N N   . PRO A 1 78  ? 9.030   -7.868  -20.767 1.00 30.47 ?  42  PRO A N   1 
ATOM   329  C CA  . PRO A 1 78  ? 7.829   -7.527  -19.979 1.00 28.91 ?  42  PRO A CA  1 
ATOM   330  C C   . PRO A 1 78  ? 6.937   -8.722  -19.700 1.00 28.59 ?  42  PRO A C   1 
ATOM   331  O O   . PRO A 1 78  ? 6.428   -8.872  -18.583 1.00 28.84 ?  42  PRO A O   1 
ATOM   332  C CB  . PRO A 1 78  ? 7.128   -6.481  -20.857 1.00 29.48 ?  42  PRO A CB  1 
ATOM   333  C CG  . PRO A 1 78  ? 8.236   -5.828  -21.575 1.00 27.40 ?  42  PRO A CG  1 
ATOM   334  C CD  . PRO A 1 78  ? 9.238   -6.917  -21.873 1.00 30.14 ?  42  PRO A CD  1 
ATOM   335  N N   . GLU A 1 79  ? 6.766   -9.599  -20.686 1.00 29.32 ?  43  GLU A N   1 
ATOM   336  C CA  . GLU A 1 79  ? 5.961   -10.797 -20.487 1.00 33.56 ?  43  GLU A CA  1 
ATOM   337  C C   . GLU A 1 79  ? 6.505   -11.623 -19.341 1.00 30.08 ?  43  GLU A C   1 
ATOM   338  O O   . GLU A 1 79  ? 5.741   -12.194 -18.559 1.00 29.54 ?  43  GLU A O   1 
ATOM   339  C CB  . GLU A 1 79  ? 5.933   -11.652 -21.757 1.00 36.48 ?  43  GLU A CB  1 
ATOM   340  C CG  . GLU A 1 79  ? 5.245   -11.036 -22.969 1.00 40.10 ?  43  GLU A CG  1 
ATOM   341  C CD  . GLU A 1 79  ? 5.763   -9.657  -23.318 1.00 38.70 ?  43  GLU A CD  1 
ATOM   342  O OE1 . GLU A 1 79  ? 4.925   -8.743  -23.505 1.00 44.10 ?  43  GLU A OE1 1 
ATOM   343  O OE2 . GLU A 1 79  ? 7.004   -9.482  -23.383 1.00 36.98 ?  43  GLU A OE2 1 
ATOM   344  N N   . GLU A 1 80  ? 7.830   -11.702 -19.231 1.00 29.25 ?  44  GLU A N   1 
ATOM   345  C CA  . GLU A 1 80  ? 8.438   -12.508 -18.182 1.00 26.71 ?  44  GLU A CA  1 
ATOM   346  C C   . GLU A 1 80  ? 8.252   -11.857 -16.818 1.00 27.94 ?  44  GLU A C   1 
ATOM   347  O O   . GLU A 1 80  ? 8.048   -12.549 -15.816 1.00 30.02 ?  44  GLU A O   1 
ATOM   348  C CB  . GLU A 1 80  ? 9.921   -12.726 -18.503 1.00 24.57 ?  44  GLU A CB  1 
ATOM   349  C CG  . GLU A 1 80  ? 10.148  -13.674 -19.682 1.00 28.27 ?  44  GLU A CG  1 
ATOM   350  C CD  . GLU A 1 80  ? 11.577  -13.640 -20.211 1.00 26.25 ?  44  GLU A CD  1 
ATOM   351  O OE1 . GLU A 1 80  ? 12.200  -12.564 -20.143 1.00 27.48 ?  44  GLU A OE1 1 
ATOM   352  O OE2 . GLU A 1 80  ? 12.067  -14.685 -20.701 1.00 29.55 ?  44  GLU A OE2 1 
ATOM   353  N N   . VAL A 1 81  ? 8.332   -10.526 -16.765 1.00 27.50 ?  45  VAL A N   1 
ATOM   354  C CA  . VAL A 1 81  ? 8.048   -9.793  -15.533 1.00 26.96 ?  45  VAL A CA  1 
ATOM   355  C C   . VAL A 1 81  ? 6.614   -10.044 -15.082 1.00 26.16 ?  45  VAL A C   1 
ATOM   356  O O   . VAL A 1 81  ? 6.355   -10.308 -13.903 1.00 23.69 ?  45  VAL A O   1 
ATOM   357  C CB  . VAL A 1 81  ? 8.330   -8.292  -15.753 1.00 26.68 ?  45  VAL A CB  1 
ATOM   358  C CG1 . VAL A 1 81  ? 8.109   -7.489  -14.475 1.00 25.09 ?  45  VAL A CG1 1 
ATOM   359  C CG2 . VAL A 1 81  ? 9.738   -8.107  -16.300 1.00 24.17 ?  45  VAL A CG2 1 
ATOM   360  N N   . GLU A 1 82  ? 5.663   -9.996  -16.013 1.00 26.09 ?  46  GLU A N   1 
ATOM   361  C CA  . GLU A 1 82  ? 4.275   -10.279 -15.652 1.00 31.72 ?  46  GLU A CA  1 
ATOM   362  C C   . GLU A 1 82  ? 4.102   -11.713 -15.174 1.00 27.75 ?  46  GLU A C   1 
ATOM   363  O O   . GLU A 1 82  ? 3.380   -11.972 -14.200 1.00 27.32 ?  46  GLU A O   1 
ATOM   364  C CB  . GLU A 1 82  ? 3.356   -10.008 -16.841 1.00 35.12 ?  46  GLU A CB  1 
ATOM   365  C CG  . GLU A 1 82  ? 3.554   -8.663  -17.484 1.00 37.34 ?  46  GLU A CG  1 
ATOM   366  C CD  . GLU A 1 82  ? 2.255   -8.079  -18.001 1.00 50.11 ?  46  GLU A CD  1 
ATOM   367  O OE1 . GLU A 1 82  ? 1.498   -8.831  -18.663 1.00 55.36 ?  46  GLU A OE1 1 
ATOM   368  O OE2 . GLU A 1 82  ? 1.997   -6.877  -17.754 1.00 48.56 ?  46  GLU A OE2 1 
ATOM   369  N N   . PHE A 1 83  ? 4.748   -12.665 -15.844 1.00 27.62 ?  47  PHE A N   1 
ATOM   370  C CA  . PHE A 1 83  ? 4.614   -14.059 -15.428 1.00 26.57 ?  47  PHE A CA  1 
ATOM   371  C C   . PHE A 1 83  ? 5.090   -14.236 -13.990 1.00 28.41 ?  47  PHE A C   1 
ATOM   372  O O   . PHE A 1 83  ? 4.408   -14.857 -13.160 1.00 28.01 ?  47  PHE A O   1 
ATOM   373  C CB  . PHE A 1 83  ? 5.398   -14.963 -16.385 1.00 28.03 ?  47  PHE A CB  1 
ATOM   374  C CG  . PHE A 1 83  ? 5.302   -16.436 -16.067 1.00 29.40 ?  47  PHE A CG  1 
ATOM   375  C CD1 . PHE A 1 83  ? 6.160   -17.024 -15.146 1.00 29.95 ?  47  PHE A CD1 1 
ATOM   376  C CD2 . PHE A 1 83  ? 4.366   -17.241 -16.710 1.00 32.18 ?  47  PHE A CD2 1 
ATOM   377  C CE1 . PHE A 1 83  ? 6.077   -18.392 -14.856 1.00 32.40 ?  47  PHE A CE1 1 
ATOM   378  C CE2 . PHE A 1 83  ? 4.286   -18.602 -16.427 1.00 30.91 ?  47  PHE A CE2 1 
ATOM   379  C CZ  . PHE A 1 83  ? 5.144   -19.174 -15.500 1.00 29.68 ?  47  PHE A CZ  1 
ATOM   380  N N   . ILE A 1 84  ? 6.256   -13.681 -13.667 1.00 27.16 ?  48  ILE A N   1 
ATOM   381  C CA  . ILE A 1 84  ? 6.787   -13.867 -12.324 1.00 26.96 ?  48  ILE A CA  1 
ATOM   382  C C   . ILE A 1 84  ? 6.010   -13.026 -11.323 1.00 20.92 ?  48  ILE A C   1 
ATOM   383  O O   . ILE A 1 84  ? 5.741   -13.468 -10.202 1.00 24.67 ?  48  ILE A O   1 
ATOM   384  C CB  . ILE A 1 84  ? 8.294   -13.566 -12.310 1.00 25.78 ?  48  ILE A CB  1 
ATOM   385  C CG1 . ILE A 1 84  ? 9.018   -14.666 -13.093 1.00 26.02 ?  48  ILE A CG1 1 
ATOM   386  C CG2 . ILE A 1 84  ? 8.827   -13.488 -10.876 1.00 21.81 ?  48  ILE A CG2 1 
ATOM   387  C CD1 . ILE A 1 84  ? 10.469  -14.378 -13.403 1.00 27.25 ?  48  ILE A CD1 1 
ATOM   388  N N   . ALA A 1 85  ? 5.608   -11.817 -11.712 1.00 22.72 ?  49  ALA A N   1 
ATOM   389  C CA  . ALA A 1 85  ? 4.882   -10.957 -10.789 1.00 25.86 ?  49  ALA A CA  1 
ATOM   390  C C   . ALA A 1 85  ? 3.569   -11.595 -10.367 1.00 28.35 ?  49  ALA A C   1 
ATOM   391  O O   . ALA A 1 85  ? 3.129   -11.425 -9.221  1.00 25.50 ?  49  ALA A O   1 
ATOM   392  C CB  . ALA A 1 85  ? 4.627   -9.588  -11.423 1.00 27.89 ?  49  ALA A CB  1 
ATOM   393  N N   . GLU A 1 86  ? 2.949   -12.361 -11.262 1.00 27.11 ?  50  GLU A N   1 
ATOM   394  C CA  . GLU A 1 86  ? 1.666   -12.977 -10.932 1.00 30.28 ?  50  GLU A CA  1 
ATOM   395  C C   . GLU A 1 86  ? 1.816   -14.066 -9.880  1.00 27.69 ?  50  GLU A C   1 
ATOM   396  O O   . GLU A 1 86  ? 0.859   -14.356 -9.153  1.00 25.68 ?  50  GLU A O   1 
ATOM   397  C CB  . GLU A 1 86  ? 1.032   -13.554 -12.190 1.00 27.91 ?  50  GLU A CB  1 
ATOM   398  C CG  . GLU A 1 86  ? -0.369  -14.119 -11.996 1.00 34.48 ?  50  GLU A CG  1 
ATOM   399  C CD  . GLU A 1 86  ? -0.792  -14.961 -13.183 1.00 37.04 ?  50  GLU A CD  1 
ATOM   400  O OE1 . GLU A 1 86  ? -0.556  -14.514 -14.326 1.00 43.07 ?  50  GLU A OE1 1 
ATOM   401  O OE2 . GLU A 1 86  ? -1.334  -16.073 -12.973 1.00 40.96 ?  50  GLU A OE2 1 
ATOM   402  N N   . ARG A 1 87  ? 3.001   -14.673 -9.777  1.00 26.55 ?  51  ARG A N   1 
ATOM   403  C CA  . ARG A 1 87  ? 3.203   -15.838 -8.927  1.00 25.61 ?  51  ARG A CA  1 
ATOM   404  C C   . ARG A 1 87  ? 3.956   -15.555 -7.629  1.00 27.77 ?  51  ARG A C   1 
ATOM   405  O O   . ARG A 1 87  ? 4.107   -16.467 -6.811  1.00 28.34 ?  51  ARG A O   1 
ATOM   406  C CB  . ARG A 1 87  ? 3.932   -16.922 -9.719  1.00 28.36 ?  51  ARG A CB  1 
ATOM   407  C CG  . ARG A 1 87  ? 3.042   -17.522 -10.790 1.00 30.81 ?  51  ARG A CG  1 
ATOM   408  C CD  . ARG A 1 87  ? 3.842   -18.139 -11.910 1.00 28.62 ?  51  ARG A CD  1 
ATOM   409  N NE  . ARG A 1 87  ? 2.955   -18.683 -12.932 1.00 34.71 ?  51  ARG A NE  1 
ATOM   410  C CZ  . ARG A 1 87  ? 2.324   -17.942 -13.834 1.00 35.81 ?  51  ARG A CZ  1 
ATOM   411  N NH1 . ARG A 1 87  ? 2.484   -16.631 -13.880 1.00 27.78 ?  51  ARG A NH1 1 
ATOM   412  N NH2 . ARG A 1 87  ? 1.506   -18.532 -14.704 1.00 36.53 ?  51  ARG A NH2 1 
ATOM   413  N N   . THR A 1 88  ? 4.437   -14.338 -7.403  1.00 27.12 ?  52  THR A N   1 
ATOM   414  C CA  . THR A 1 88  ? 5.222   -14.129 -6.195  1.00 25.46 ?  52  THR A CA  1 
ATOM   415  C C   . THR A 1 88  ? 5.084   -12.694 -5.726  1.00 23.61 ?  52  THR A C   1 
ATOM   416  O O   . THR A 1 88  ? 4.759   -11.784 -6.498  1.00 24.83 ?  52  THR A O   1 
ATOM   417  C CB  . THR A 1 88  ? 6.709   -14.486 -6.399  1.00 22.23 ?  52  THR A CB  1 
ATOM   418  O OG1 . THR A 1 88  ? 7.373   -14.506 -5.130  1.00 23.87 ?  52  THR A OG1 1 
ATOM   419  C CG2 . THR A 1 88  ? 7.418   -13.490 -7.319  1.00 18.45 ?  52  THR A CG2 1 
ATOM   420  N N   . ASP A 1 89  ? 5.334   -12.514 -4.434  1.00 23.73 ?  53  ASP A N   1 
ATOM   421  C CA  . ASP A 1 89  ? 5.451   -11.201 -3.814  1.00 27.57 ?  53  ASP A CA  1 
ATOM   422  C C   . ASP A 1 89  ? 6.868   -10.904 -3.337  1.00 25.12 ?  53  ASP A C   1 
ATOM   423  O O   . ASP A 1 89  ? 7.123   -9.815  -2.812  1.00 24.32 ?  53  ASP A O   1 
ATOM   424  C CB  . ASP A 1 89  ? 4.466   -11.095 -2.650  1.00 25.82 ?  53  ASP A CB  1 
ATOM   425  C CG  . ASP A 1 89  ? 3.035   -11.154 -3.123  1.00 29.09 ?  53  ASP A CG  1 
ATOM   426  O OD1 . ASP A 1 89  ? 2.663   -10.282 -3.947  1.00 28.86 ?  53  ASP A OD1 1 
ATOM   427  O OD2 . ASP A 1 89  ? 2.312   -12.082 -2.703  1.00 24.09 ?  53  ASP A OD2 1 
ATOM   428  N N   . PHE A 1 90  ? 7.802   -11.813 -3.573  1.00 22.72 ?  54  PHE A N   1 
ATOM   429  C CA  . PHE A 1 90  ? 9.094   -11.798 -2.900  1.00 21.19 ?  54  PHE A CA  1 
ATOM   430  C C   . PHE A 1 90  ? 10.083  -12.458 -3.845  1.00 24.59 ?  54  PHE A C   1 
ATOM   431  O O   . PHE A 1 90  ? 9.907   -13.633 -4.191  1.00 21.29 ?  54  PHE A O   1 
ATOM   432  C CB  . PHE A 1 90  ? 8.972   -12.555 -1.575  1.00 20.70 ?  54  PHE A CB  1 
ATOM   433  C CG  . PHE A 1 90  ? 10.115  -12.354 -0.616  1.00 23.08 ?  54  PHE A CG  1 
ATOM   434  C CD1 . PHE A 1 90  ? 10.997  -11.288 -0.743  1.00 20.65 ?  54  PHE A CD1 1 
ATOM   435  C CD2 . PHE A 1 90  ? 10.279  -13.236 0.446   1.00 20.61 ?  54  PHE A CD2 1 
ATOM   436  C CE1 . PHE A 1 90  ? 12.021  -11.113 0.161   1.00 21.13 ?  54  PHE A CE1 1 
ATOM   437  C CE2 . PHE A 1 90  ? 11.282  -13.075 1.351   1.00 18.95 ?  54  PHE A CE2 1 
ATOM   438  C CZ  . PHE A 1 90  ? 12.182  -12.021 1.211   1.00 22.48 ?  54  PHE A CZ  1 
ATOM   439  N N   . LEU A 1 91  ? 11.082  -11.703 -4.313  1.00 22.49 ?  55  LEU A N   1 
ATOM   440  C CA  . LEU A 1 91  ? 12.063  -12.273 -5.227  1.00 22.13 ?  55  LEU A CA  1 
ATOM   441  C C   . LEU A 1 91  ? 13.417  -11.599 -5.039  1.00 22.07 ?  55  LEU A C   1 
ATOM   442  O O   . LEU A 1 91  ? 13.535  -10.535 -4.428  1.00 19.60 ?  55  LEU A O   1 
ATOM   443  C CB  . LEU A 1 91  ? 11.600  -12.173 -6.691  1.00 21.40 ?  55  LEU A CB  1 
ATOM   444  C CG  . LEU A 1 91  ? 11.444  -10.782 -7.322  1.00 20.03 ?  55  LEU A CG  1 
ATOM   445  C CD1 . LEU A 1 91  ? 12.775  -10.205 -7.867  1.00 22.10 ?  55  LEU A CD1 1 
ATOM   446  C CD2 . LEU A 1 91  ? 10.382  -10.859 -8.413  1.00 21.26 ?  55  LEU A CD2 1 
ATOM   447  N N   . CYS A 1 92  ? 14.449  -12.235 -5.592  1.00 21.83 ?  56  CYS A N   1 
ATOM   448  C CA  . CYS A 1 92  ? 15.801  -11.706 -5.536  1.00 20.68 ?  56  CYS A CA  1 
ATOM   449  C C   . CYS A 1 92  ? 16.420  -11.780 -6.926  1.00 21.12 ?  56  CYS A C   1 
ATOM   450  O O   . CYS A 1 92  ? 16.323  -12.815 -7.588  1.00 22.18 ?  56  CYS A O   1 
ATOM   451  C CB  . CYS A 1 92  ? 16.638  -12.489 -4.530  1.00 20.11 ?  56  CYS A CB  1 
ATOM   452  S SG  . CYS A 1 92  ? 18.388  -12.084 -4.596  1.00 23.79 ?  56  CYS A SG  1 
ATOM   453  N N   . ILE A 1 93  ? 17.061  -10.689 -7.360  1.00 24.12 ?  57  ILE A N   1 
ATOM   454  C CA  . ILE A 1 93  ? 17.764  -10.637 -8.643  1.00 21.28 ?  57  ILE A CA  1 
ATOM   455  C C   . ILE A 1 93  ? 19.187  -11.139 -8.430  1.00 22.49 ?  57  ILE A C   1 
ATOM   456  O O   . ILE A 1 93  ? 19.894  -10.635 -7.547  1.00 21.12 ?  57  ILE A O   1 
ATOM   457  C CB  . ILE A 1 93  ? 17.786  -9.203  -9.212  1.00 18.53 ?  57  ILE A CB  1 
ATOM   458  C CG1 . ILE A 1 93  ? 16.385  -8.667  -9.530  1.00 20.25 ?  57  ILE A CG1 1 
ATOM   459  C CG2 . ILE A 1 93  ? 18.641  -9.158  -10.451 1.00 19.82 ?  57  ILE A CG2 1 
ATOM   460  C CD1 . ILE A 1 93  ? 15.565  -9.603  -10.410 1.00 25.96 ?  57  ILE A CD1 1 
ATOM   461  N N   . GLU A 1 94  ? 19.617  -12.061 -9.297  1.00 20.57 ?  58  GLU A N   1 
ATOM   462  C CA  . GLU A 1 94  ? 20.911  -12.781 -9.131  1.00 22.59 ?  58  GLU A CA  1 
ATOM   463  C C   . GLU A 1 94  ? 22.194  -11.978 -9.384  1.00 21.80 ?  58  GLU A C   1 
ATOM   464  O O   . GLU A 1 94  ? 22.120  -10.887 -9.949  1.00 22.80 ?  58  GLU A O   1 
ATOM   465  C CB  . GLU A 1 94  ? 20.891  -14.103 -9.905  1.00 23.78 ?  58  GLU A CB  1 
ATOM   466  C CG  . GLU A 1 94  ? 20.669  -15.314 -9.013  1.00 23.33 ?  58  GLU A CG  1 
ATOM   467  C CD  . GLU A 1 94  ? 21.857  -15.765 -8.176  1.00 26.29 ?  58  GLU A CD  1 
ATOM   468  O OE1 . GLU A 1 94  ? 22.915  -15.126 -8.255  1.00 26.45 ?  58  GLU A OE1 1 
ATOM   469  O OE2 . GLU A 1 94  ? 21.718  -16.760 -7.448  1.00 24.19 ?  58  GLU A OE2 1 
ATOM   470  N N   . LYS A 1 95  ? 23.323  -12.581 -9.026  1.00 24.31 ?  59  LYS A N   1 
ATOM   471  C CA  . LYS A 1 95  ? 24.648  -11.915 -8.991  1.00 24.32 ?  59  LYS A CA  1 
ATOM   472  C C   . LYS A 1 95  ? 25.136  -11.298 -10.299 1.00 26.51 ?  59  LYS A C   1 
ATOM   473  O O   . LYS A 1 95  ? 25.983  -10.423 -10.218 1.00 22.11 ?  59  LYS A O   1 
ATOM   474  C CB  . LYS A 1 95  ? 25.666  -12.968 -8.547  1.00 22.76 ?  59  LYS A CB  1 
ATOM   475  C CG  . LYS A 1 95  ? 25.900  -14.109 -9.528  1.00 26.17 ?  59  LYS A CG  1 
ATOM   476  C CD  . LYS A 1 95  ? 26.979  -15.065 -9.081  1.00 28.85 ?  59  LYS A CD  1 
ATOM   477  C CE  . LYS A 1 95  ? 26.706  -15.675 -7.724  1.00 29.25 ?  59  LYS A CE  1 
ATOM   478  N NZ  . LYS A 1 95  ? 25.442  -16.444 -7.715  1.00 32.77 ?  59  LYS A NZ  1 
ATOM   479  N N   . SER A 1 96  ? 24.640  -11.755 -11.433 1.00 23.78 ?  60  SER A N   1 
ATOM   480  C CA  . SER A 1 96  ? 25.219  -11.263 -12.676 1.00 24.08 ?  60  SER A CA  1 
ATOM   481  C C   . SER A 1 96  ? 24.188  -10.636 -13.599 1.00 25.94 ?  60  SER A C   1 
ATOM   482  O O   . SER A 1 96  ? 24.496  -10.389 -14.768 1.00 27.45 ?  60  SER A O   1 
ATOM   483  C CB  . SER A 1 96  ? 25.938  -12.401 -13.408 1.00 26.65 ?  60  SER A CB  1 
ATOM   484  O OG  . SER A 1 96  ? 25.009  -13.389 -13.851 1.00 28.81 ?  60  SER A OG  1 
ATOM   485  N N   . HIS A 1 97  ? 22.982  -10.358 -13.104 1.00 25.43 ?  61  HIS A N   1 
ATOM   486  C CA  . HIS A 1 97  ? 21.860  -10.107 -13.995 1.00 26.81 ?  61  HIS A CA  1 
ATOM   487  C C   . HIS A 1 97  ? 22.083  -8.857  -14.828 1.00 27.61 ?  61  HIS A C   1 
ATOM   488  O O   . HIS A 1 97  ? 22.457  -7.802  -14.301 1.00 24.40 ?  61  HIS A O   1 
ATOM   489  C CB  . HIS A 1 97  ? 20.564  -9.971  -13.206 1.00 23.92 ?  61  HIS A CB  1 
ATOM   490  C CG  . HIS A 1 97  ? 19.361  -9.799  -14.076 1.00 27.03 ?  61  HIS A CG  1 
ATOM   491  N ND1 . HIS A 1 97  ? 18.939  -10.770 -14.961 1.00 25.26 ?  61  HIS A ND1 1 
ATOM   492  C CD2 . HIS A 1 97  ? 18.508  -8.757  -14.226 1.00 26.11 ?  61  HIS A CD2 1 
ATOM   493  C CE1 . HIS A 1 97  ? 17.867  -10.342 -15.605 1.00 25.36 ?  61  HIS A CE1 1 
ATOM   494  N NE2 . HIS A 1 97  ? 17.585  -9.124  -15.178 1.00 22.55 ?  61  HIS A NE2 1 
ATOM   495  N N   . GLY A 1 98  ? 21.828  -8.986  -16.135 1.00 29.02 ?  62  GLY A N   1 
ATOM   496  C CA  . GLY A 1 98  ? 21.933  -7.871  -17.058 1.00 25.80 ?  62  GLY A CA  1 
ATOM   497  C C   . GLY A 1 98  ? 23.312  -7.277  -17.147 1.00 27.52 ?  62  GLY A C   1 
ATOM   498  O O   . GLY A 1 98  ? 23.466  -6.146  -17.611 1.00 29.30 ?  62  GLY A O   1 
ATOM   499  N N   . ARG A 1 99  ? 24.326  -8.013  -16.702 1.00 27.45 ?  63  ARG A N   1 
ATOM   500  C CA  . ARG A 1 99  ? 25.685  -7.498  -16.749 1.00 29.09 ?  63  ARG A CA  1 
ATOM   501  C C   . ARG A 1 99  ? 26.116  -7.197  -18.178 1.00 33.35 ?  63  ARG A C   1 
ATOM   502  O O   . ARG A 1 99  ? 26.719  -6.151  -18.445 1.00 29.21 ?  63  ARG A O   1 
ATOM   503  C CB  . ARG A 1 99  ? 26.645  -8.495  -16.118 1.00 29.42 ?  63  ARG A CB  1 
ATOM   504  C CG  . ARG A 1 99  ? 28.089  -8.089  -16.305 1.00 32.06 ?  63  ARG A CG  1 
ATOM   505  C CD  . ARG A 1 99  ? 28.986  -8.958  -15.449 1.00 37.51 ?  63  ARG A CD  1 
ATOM   506  N NE  . ARG A 1 99  ? 30.406  -8.623  -15.535 1.00 42.54 ?  63  ARG A NE  1 
ATOM   507  C CZ  . ARG A 1 99  ? 30.935  -7.415  -15.360 1.00 45.87 ?  63  ARG A CZ  1 
ATOM   508  N NH1 . ARG A 1 99  ? 30.187  -6.352  -15.088 1.00 38.58 ?  63  ARG A NH1 1 
ATOM   509  N NH2 . ARG A 1 99  ? 32.257  -7.274  -15.437 1.00 45.88 ?  63  ARG A NH2 1 
ATOM   510  N N   . THR A 1 100 ? 25.828  -8.103  -19.117 1.00 29.60 ?  64  THR A N   1 
ATOM   511  C CA  . THR A 1 100 ? 26.250  -7.837  -20.492 1.00 30.89 ?  64  THR A CA  1 
ATOM   512  C C   . THR A 1 100 ? 25.481  -6.666  -21.098 1.00 34.70 ?  64  THR A C   1 
ATOM   513  O O   . THR A 1 100 ? 26.129  -5.691  -21.520 1.00 37.50 ?  64  THR A O   1 
ATOM   514  C CB  . THR A 1 100 ? 26.165  -9.119  -21.329 1.00 33.74 ?  64  THR A CB  1 
ATOM   515  O OG1 . THR A 1 100 ? 26.908  -10.152 -20.674 1.00 32.27 ?  64  THR A OG1 1 
ATOM   516  C CG2 . THR A 1 100 ? 26.764  -8.903  -22.726 1.00 33.84 ?  64  THR A CG2 1 
ATOM   517  N N   . PRO A 1 101 ? 24.138  -6.650  -21.132 1.00 29.22 ?  65  PRO A N   1 
ATOM   518  C CA  . PRO A 1 101 ? 23.464  -5.503  -21.765 1.00 35.22 ?  65  PRO A CA  1 
ATOM   519  C C   . PRO A 1 101 ? 23.697  -4.184  -21.052 1.00 34.14 ?  65  PRO A C   1 
ATOM   520  O O   . PRO A 1 101 ? 23.664  -3.140  -21.709 1.00 33.85 ?  65  PRO A O   1 
ATOM   521  C CB  . PRO A 1 101 ? 21.980  -5.900  -21.734 1.00 31.55 ?  65  PRO A CB  1 
ATOM   522  C CG  . PRO A 1 101 ? 21.875  -6.879  -20.635 1.00 27.30 ?  65  PRO A CG  1 
ATOM   523  C CD  . PRO A 1 101 ? 23.154  -7.655  -20.694 1.00 28.06 ?  65  PRO A CD  1 
ATOM   524  N N   . LEU A 1 102 ? 23.936  -4.184  -19.737 1.00 33.16 ?  66  LEU A N   1 
ATOM   525  C CA  . LEU A 1 102 ? 24.003  -2.939  -18.983 1.00 30.95 ?  66  LEU A CA  1 
ATOM   526  C C   . LEU A 1 102 ? 25.370  -2.653  -18.385 1.00 31.21 ?  66  LEU A C   1 
ATOM   527  O O   . LEU A 1 102 ? 25.571  -1.558  -17.858 1.00 34.05 ?  66  LEU A O   1 
ATOM   528  C CB  . LEU A 1 102 ? 22.950  -2.928  -17.862 1.00 28.55 ?  66  LEU A CB  1 
ATOM   529  C CG  . LEU A 1 102 ? 21.491  -2.953  -18.333 1.00 28.14 ?  66  LEU A CG  1 
ATOM   530  C CD1 . LEU A 1 102 ? 20.517  -2.925  -17.157 1.00 30.77 ?  66  LEU A CD1 1 
ATOM   531  C CD2 . LEU A 1 102 ? 21.202  -1.810  -19.289 1.00 30.40 ?  66  LEU A CD2 1 
ATOM   532  N N   . GLY A 1 103 ? 26.312  -3.588  -18.447 1.00 31.91 ?  67  GLY A N   1 
ATOM   533  C CA  . GLY A 1 103 ? 27.648  -3.348  -17.973 1.00 31.59 ?  67  GLY A CA  1 
ATOM   534  C C   . GLY A 1 103 ? 27.881  -3.664  -16.508 1.00 33.39 ?  67  GLY A C   1 
ATOM   535  O O   . GLY A 1 103 ? 29.026  -3.949  -16.125 1.00 31.29 ?  67  GLY A O   1 
ATOM   536  N N   . ALA A 1 104 ? 26.839  -3.615  -15.674 1.00 23.95 ?  68  ALA A N   1 
ATOM   537  C CA  . ALA A 1 104 ? 27.026  -3.846  -14.243 1.00 29.18 ?  68  ALA A CA  1 
ATOM   538  C C   . ALA A 1 104 ? 25.819  -4.562  -13.657 1.00 27.97 ?  68  ALA A C   1 
ATOM   539  O O   . ALA A 1 104 ? 24.678  -4.152  -13.894 1.00 29.10 ?  68  ALA A O   1 
ATOM   540  C CB  . ALA A 1 104 ? 27.260  -2.533  -13.494 1.00 27.40 ?  68  ALA A CB  1 
ATOM   541  N N   . ALA A 1 105 ? 26.085  -5.594  -12.851 1.00 24.50 ?  69  ALA A N   1 
ATOM   542  C CA  . ALA A 1 105 ? 25.007  -6.420  -12.313 1.00 25.17 ?  69  ALA A CA  1 
ATOM   543  C C   . ALA A 1 105 ? 24.085  -5.634  -11.396 1.00 25.89 ?  69  ALA A C   1 
ATOM   544  O O   . ALA A 1 105 ? 22.926  -6.018  -11.203 1.00 28.43 ?  69  ALA A O   1 
ATOM   545  C CB  . ALA A 1 105 ? 25.576  -7.624  -11.562 1.00 23.77 ?  69  ALA A CB  1 
ATOM   546  N N   . GLU A 1 106 ? 24.555  -4.550  -10.798 1.00 25.56 ?  70  GLU A N   1 
ATOM   547  C CA  . GLU A 1 106 ? 23.593  -3.835  -9.977  1.00 25.66 ?  70  GLU A CA  1 
ATOM   548  C C   . GLU A 1 106 ? 22.615  -3.030  -10.822 1.00 25.55 ?  70  GLU A C   1 
ATOM   549  O O   . GLU A 1 106 ? 21.541  -2.677  -10.324 1.00 23.32 ?  70  GLU A O   1 
ATOM   550  C CB  . GLU A 1 106 ? 24.294  -2.929  -8.974  1.00 24.75 ?  70  GLU A CB  1 
ATOM   551  C CG  . GLU A 1 106 ? 24.775  -1.652  -9.569  1.00 25.75 ?  70  GLU A CG  1 
ATOM   552  C CD  . GLU A 1 106 ? 26.134  -1.815  -10.202 1.00 27.27 ?  70  GLU A CD  1 
ATOM   553  O OE1 . GLU A 1 106 ? 26.575  -2.971  -10.344 1.00 23.36 ?  70  GLU A OE1 1 
ATOM   554  O OE2 . GLU A 1 106 ? 26.746  -0.787  -10.556 1.00 25.37 ?  70  GLU A OE2 1 
ATOM   555  N N   . LEU A 1 107 ? 22.938  -2.759  -12.091 1.00 23.30 ?  71  LEU A N   1 
ATOM   556  C CA  . LEU A 1 107 ? 21.961  -2.080  -12.937 1.00 27.41 ?  71  LEU A CA  1 
ATOM   557  C C   . LEU A 1 107 ? 20.932  -3.069  -13.451 1.00 28.93 ?  71  LEU A C   1 
ATOM   558  O O   . LEU A 1 107 ? 19.796  -2.685  -13.767 1.00 21.76 ?  71  LEU A O   1 
ATOM   559  C CB  . LEU A 1 107 ? 22.659  -1.356  -14.097 1.00 21.08 ?  71  LEU A CB  1 
ATOM   560  C CG  . LEU A 1 107 ? 23.768  -0.416  -13.621 1.00 20.39 ?  71  LEU A CG  1 
ATOM   561  C CD1 . LEU A 1 107 ? 24.570  0.117   -14.787 1.00 33.07 ?  71  LEU A CD1 1 
ATOM   562  C CD2 . LEU A 1 107 ? 23.224  0.741   -12.763 1.00 23.18 ?  71  LEU A CD2 1 
ATOM   563  N N   . GLY A 1 108 ? 21.320  -4.344  -13.535 1.00 25.08 ?  72  GLY A N   1 
ATOM   564  C CA  . GLY A 1 108 ? 20.339  -5.383  -13.794 1.00 25.42 ?  72  GLY A CA  1 
ATOM   565  C C   . GLY A 1 108 ? 19.320  -5.469  -12.681 1.00 22.31 ?  72  GLY A C   1 
ATOM   566  O O   . GLY A 1 108 ? 18.113  -5.497  -12.930 1.00 24.05 ?  72  GLY A O   1 
ATOM   567  N N   . ALA A 1 109 ? 19.797  -5.482  -11.431 1.00 22.34 ?  73  ALA A N   1 
ATOM   568  C CA  . ALA A 1 109 ? 18.884  -5.419  -10.292 1.00 23.92 ?  73  ALA A CA  1 
ATOM   569  C C   . ALA A 1 109 ? 18.032  -4.157  -10.338 1.00 22.20 ?  73  ALA A C   1 
ATOM   570  O O   . ALA A 1 109 ? 16.815  -4.211  -10.115 1.00 21.83 ?  73  ALA A O   1 
ATOM   571  C CB  . ALA A 1 109 ? 19.665  -5.473  -8.974  1.00 19.24 ?  73  ALA A CB  1 
ATOM   572  N N   . LYS A 1 110 ? 18.654  -3.012  -10.638 1.00 22.52 ?  74  LYS A N   1 
ATOM   573  C CA  . LYS A 1 110 ? 17.910  -1.759  -10.651 1.00 25.64 ?  74  LYS A CA  1 
ATOM   574  C C   . LYS A 1 110 ? 16.774  -1.813  -11.662 1.00 21.81 ?  74  LYS A C   1 
ATOM   575  O O   . LYS A 1 110 ? 15.641  -1.418  -11.359 1.00 24.00 ?  74  LYS A O   1 
ATOM   576  C CB  . LYS A 1 110 ? 18.859  -0.593  -10.958 1.00 22.46 ?  74  LYS A CB  1 
ATOM   577  C CG  . LYS A 1 110 ? 18.222  0.802   -10.852 1.00 24.34 ?  74  LYS A CG  1 
ATOM   578  C CD  . LYS A 1 110 ? 19.216  1.911   -11.268 1.00 29.81 ?  74  LYS A CD  1 
ATOM   579  C CE  . LYS A 1 110 ? 18.823  3.278   -10.700 1.00 35.69 ?  74  LYS A CE  1 
ATOM   580  N NZ  . LYS A 1 110 ? 17.736  3.935   -11.483 1.00 36.48 ?  74  LYS A NZ  1 
ATOM   581  N N   . HIS A 1 111 ? 17.062  -2.316  -12.866 1.00 23.49 ?  75  HIS A N   1 
ATOM   582  C CA  . HIS A 1 111 ? 16.071  -2.368  -13.938 1.00 22.76 ?  75  HIS A CA  1 
ATOM   583  C C   . HIS A 1 111 ? 14.901  -3.267  -13.571 1.00 23.08 ?  75  HIS A C   1 
ATOM   584  O O   . HIS A 1 111 ? 13.734  -2.904  -13.771 1.00 24.41 ?  75  HIS A O   1 
ATOM   585  C CB  . HIS A 1 111 ? 16.741  -2.868  -15.217 1.00 25.99 ?  75  HIS A CB  1 
ATOM   586  C CG  . HIS A 1 111 ? 15.790  -3.159  -16.343 1.00 29.27 ?  75  HIS A CG  1 
ATOM   587  N ND1 . HIS A 1 111 ? 15.596  -2.291  -17.396 1.00 27.33 ?  75  HIS A ND1 1 
ATOM   588  C CD2 . HIS A 1 111 ? 15.014  -4.239  -16.600 1.00 25.98 ?  75  HIS A CD2 1 
ATOM   589  C CE1 . HIS A 1 111 ? 14.724  -2.813  -18.241 1.00 29.13 ?  75  HIS A CE1 1 
ATOM   590  N NE2 . HIS A 1 111 ? 14.352  -3.993  -17.780 1.00 26.60 ?  75  HIS A NE2 1 
ATOM   591  N N   . GLU A 1 112 ? 15.185  -4.463  -13.057 1.00 24.61 ?  76  GLU A N   1 
ATOM   592  C CA  . GLU A 1 112 ? 14.089  -5.389  -12.784 1.00 21.97 ?  76  GLU A CA  1 
ATOM   593  C C   . GLU A 1 112 ? 13.300  -4.984  -11.555 1.00 22.38 ?  76  GLU A C   1 
ATOM   594  O O   . GLU A 1 112 ? 12.084  -5.214  -11.500 1.00 22.10 ?  76  GLU A O   1 
ATOM   595  C CB  . GLU A 1 112 ? 14.601  -6.824  -12.603 1.00 22.85 ?  76  GLU A CB  1 
ATOM   596  C CG  . GLU A 1 112 ? 15.502  -7.313  -13.700 1.00 22.74 ?  76  GLU A CG  1 
ATOM   597  C CD  . GLU A 1 112 ? 14.794  -7.479  -15.027 1.00 25.45 ?  76  GLU A CD  1 
ATOM   598  O OE1 . GLU A 1 112 ? 13.579  -7.194  -15.105 1.00 25.98 ?  76  GLU A OE1 1 
ATOM   599  O OE2 . GLU A 1 112 ? 15.457  -7.894  -16.003 1.00 25.50 ?  76  GLU A OE2 1 
ATOM   600  N N   . ALA A 1 113 ? 13.961  -4.417  -10.549 1.00 21.99 ?  77  ALA A N   1 
ATOM   601  C CA  . ALA A 1 113 ? 13.220  -3.943  -9.386  1.00 22.41 ?  77  ALA A CA  1 
ATOM   602  C C   . ALA A 1 113 ? 12.159  -2.932  -9.805  1.00 27.70 ?  77  ALA A C   1 
ATOM   603  O O   . ALA A 1 113 ? 11.017  -2.964  -9.315  1.00 21.65 ?  77  ALA A O   1 
ATOM   604  C CB  . ALA A 1 113 ? 14.182  -3.333  -8.361  1.00 22.55 ?  77  ALA A CB  1 
ATOM   605  N N   . ALA A 1 114 ? 12.508  -2.049  -10.740 1.00 25.38 ?  78  ALA A N   1 
ATOM   606  C CA  . ALA A 1 114 ? 11.560  -1.026  -11.168 1.00 29.74 ?  78  ALA A CA  1 
ATOM   607  C C   . ALA A 1 114 ? 10.478  -1.624  -12.050 1.00 25.07 ?  78  ALA A C   1 
ATOM   608  O O   . ALA A 1 114 ? 9.312   -1.235  -11.948 1.00 28.82 ?  78  ALA A O   1 
ATOM   609  C CB  . ALA A 1 114 ? 12.286  0.103   -11.896 1.00 24.91 ?  78  ALA A CB  1 
ATOM   610  N N   . ALA A 1 115 ? 10.846  -2.580  -12.913 1.00 26.09 ?  79  ALA A N   1 
ATOM   611  C CA  . ALA A 1 115 ? 9.850   -3.246  -13.749 1.00 31.56 ?  79  ALA A CA  1 
ATOM   612  C C   . ALA A 1 115 ? 8.826   -3.992  -12.902 1.00 28.01 ?  79  ALA A C   1 
ATOM   613  O O   . ALA A 1 115 ? 7.619   -3.907  -13.151 1.00 28.55 ?  79  ALA A O   1 
ATOM   614  C CB  . ALA A 1 115 ? 10.533  -4.209  -14.728 1.00 27.73 ?  79  ALA A CB  1 
ATOM   615  N N   . PHE A 1 116 ? 9.286   -4.725  -11.894 1.00 26.65 ?  80  PHE A N   1 
ATOM   616  C CA  . PHE A 1 116 ? 8.355   -5.481  -11.065 1.00 28.90 ?  80  PHE A CA  1 
ATOM   617  C C   . PHE A 1 116 ? 7.462   -4.552  -10.257 1.00 30.73 ?  80  PHE A C   1 
ATOM   618  O O   . PHE A 1 116 ? 6.265   -4.809  -10.101 1.00 29.94 ?  80  PHE A O   1 
ATOM   619  C CB  . PHE A 1 116 ? 9.127   -6.427  -10.149 1.00 24.67 ?  80  PHE A CB  1 
ATOM   620  C CG  . PHE A 1 116 ? 9.500   -7.714  -10.818 1.00 28.60 ?  80  PHE A CG  1 
ATOM   621  C CD1 . PHE A 1 116 ? 8.553   -8.716  -10.982 1.00 25.62 ?  80  PHE A CD1 1 
ATOM   622  C CD2 . PHE A 1 116 ? 10.787  -7.923  -11.302 1.00 25.68 ?  80  PHE A CD2 1 
ATOM   623  C CE1 . PHE A 1 116 ? 8.876   -9.909  -11.618 1.00 26.01 ?  80  PHE A CE1 1 
ATOM   624  C CE2 . PHE A 1 116 ? 11.115  -9.109  -11.930 1.00 25.76 ?  80  PHE A CE2 1 
ATOM   625  C CZ  . PHE A 1 116 ? 10.154  -10.110 -12.078 1.00 21.97 ?  80  PHE A CZ  1 
ATOM   626  N N   . LYS A 1 117 ? 8.021   -3.463  -9.747  1.00 26.97 ?  81  LYS A N   1 
ATOM   627  C CA  . LYS A 1 117 ? 7.236   -2.582  -8.902  1.00 31.31 ?  81  LYS A CA  1 
ATOM   628  C C   . LYS A 1 117 ? 6.244   -1.743  -9.700  1.00 34.12 ?  81  LYS A C   1 
ATOM   629  O O   . LYS A 1 117 ? 5.218   -1.328  -9.152  1.00 35.93 ?  81  LYS A O   1 
ATOM   630  C CB  . LYS A 1 117 ? 8.172   -1.700  -8.087  1.00 32.62 ?  81  LYS A CB  1 
ATOM   631  C CG  . LYS A 1 117 ? 8.873   -2.500  -7.007  1.00 34.30 ?  81  LYS A CG  1 
ATOM   632  C CD  . LYS A 1 117 ? 9.230   -1.642  -5.820  1.00 38.91 ?  81  LYS A CD  1 
ATOM   633  C CE  . LYS A 1 117 ? 10.632  -1.954  -5.347  1.00 33.58 ?  81  LYS A CE  1 
ATOM   634  N NZ  . LYS A 1 117 ? 10.676  -1.857  -3.871  1.00 41.12 ?  81  LYS A NZ  1 
ATOM   635  N N   . LYS A 1 118 ? 6.525   -1.473  -10.977 1.00 30.42 ?  82  LYS A N   1 
ATOM   636  C CA  . LYS A 1 118 ? 5.495   -0.888  -11.830 1.00 34.98 ?  82  LYS A CA  1 
ATOM   637  C C   . LYS A 1 118 ? 4.255   -1.777  -11.857 1.00 36.99 ?  82  LYS A C   1 
ATOM   638  O O   . LYS A 1 118 ? 3.130   -1.305  -11.659 1.00 34.78 ?  82  LYS A O   1 
ATOM   639  C CB  . LYS A 1 118 ? 6.037   -0.656  -13.239 1.00 34.20 ?  82  LYS A CB  1 
ATOM   640  C CG  . LYS A 1 118 ? 4.955   -0.281  -14.254 1.00 48.47 ?  82  LYS A CG  1 
ATOM   641  C CD  . LYS A 1 118 ? 5.491   0.628   -15.361 1.00 50.26 ?  82  LYS A CD  1 
ATOM   642  C CE  . LYS A 1 118 ? 4.395   1.016   -16.364 1.00 51.80 ?  82  LYS A CE  1 
ATOM   643  N NZ  . LYS A 1 118 ? 4.414   0.157   -17.587 1.00 51.75 ?  82  LYS A NZ  1 
ATOM   644  N N   . ILE A 1 119 ? 4.446   -3.081  -12.070 1.00 36.36 ?  83  ILE A N   1 
ATOM   645  C CA  . ILE A 1 119 ? 3.321   -4.017  -12.043 1.00 33.35 ?  83  ILE A CA  1 
ATOM   646  C C   . ILE A 1 119 ? 2.760   -4.139  -10.633 1.00 37.28 ?  83  ILE A C   1 
ATOM   647  O O   . ILE A 1 119 ? 1.568   -3.904  -10.387 1.00 33.90 ?  83  ILE A O   1 
ATOM   648  C CB  . ILE A 1 119 ? 3.757   -5.396  -12.551 1.00 34.70 ?  83  ILE A CB  1 
ATOM   649  C CG1 . ILE A 1 119 ? 3.941   -5.390  -14.043 1.00 35.63 ?  83  ILE A CG1 1 
ATOM   650  C CG2 . ILE A 1 119 ? 2.715   -6.440  -12.180 1.00 39.78 ?  83  ILE A CG2 1 
ATOM   651  C CD1 . ILE A 1 119 ? 4.270   -6.747  -14.525 1.00 36.39 ?  83  ILE A CD1 1 
ATOM   652  N N   . LYS A 1 120 ? 3.619   -4.542  -9.693  1.00 36.17 ?  84  LYS A N   1 
ATOM   653  C CA  . LYS A 1 120 ? 3.254   -4.895  -8.323  1.00 34.05 ?  84  LYS A CA  1 
ATOM   654  C C   . LYS A 1 120 ? 3.971   -3.942  -7.380  1.00 36.98 ?  84  LYS A C   1 
ATOM   655  O O   . LYS A 1 120 ? 5.116   -4.202  -6.977  1.00 36.22 ?  84  LYS A O   1 
ATOM   656  C CB  . LYS A 1 120 ? 3.641   -6.341  -8.018  1.00 33.79 ?  84  LYS A CB  1 
ATOM   657  C CG  . LYS A 1 120 ? 2.491   -7.291  -7.841  1.00 33.97 ?  84  LYS A CG  1 
ATOM   658  C CD  . LYS A 1 120 ? 2.997   -8.678  -7.482  1.00 27.62 ?  84  LYS A CD  1 
ATOM   659  C CE  . LYS A 1 120 ? 1.867   -9.560  -7.027  1.00 29.12 ?  84  LYS A CE  1 
ATOM   660  N NZ  . LYS A 1 120 ? 2.345   -10.892 -6.559  1.00 27.36 ?  84  LYS A NZ  1 
ATOM   661  N N   . PRO A 1 121 ? 3.347   -2.830  -7.003  1.00 36.83 ?  85  PRO A N   1 
ATOM   662  C CA  . PRO A 1 121 ? 4.060   -1.855  -6.164  1.00 37.45 ?  85  PRO A CA  1 
ATOM   663  C C   . PRO A 1 121 ? 4.503   -2.416  -4.823  1.00 36.53 ?  85  PRO A C   1 
ATOM   664  O O   . PRO A 1 121 ? 5.521   -1.970  -4.286  1.00 38.53 ?  85  PRO A O   1 
ATOM   665  C CB  . PRO A 1 121 ? 3.038   -0.720  -5.999  1.00 39.85 ?  85  PRO A CB  1 
ATOM   666  C CG  . PRO A 1 121 ? 2.091   -0.885  -7.172  1.00 38.97 ?  85  PRO A CG  1 
ATOM   667  C CD  . PRO A 1 121 ? 2.024   -2.351  -7.439  1.00 37.67 ?  85  PRO A CD  1 
ATOM   668  N N   . ASP A 1 122 ? 3.776   -3.387  -4.272  1.00 41.59 ?  86  ASP A N   1 
ATOM   669  C CA  . ASP A 1 122 ? 4.067   -3.949  -2.957  1.00 43.67 ?  86  ASP A CA  1 
ATOM   670  C C   . ASP A 1 122 ? 5.125   -5.046  -2.996  1.00 38.59 ?  86  ASP A C   1 
ATOM   671  O O   . ASP A 1 122 ? 5.516   -5.561  -1.940  1.00 35.93 ?  86  ASP A O   1 
ATOM   672  C CB  . ASP A 1 122 ? 2.778   -4.501  -2.342  1.00 42.62 ?  86  ASP A CB  1 
ATOM   673  C CG  . ASP A 1 122 ? 1.940   -3.421  -1.677  1.00 53.94 ?  86  ASP A CG  1 
ATOM   674  O OD1 . ASP A 1 122 ? 2.476   -2.309  -1.441  1.00 52.52 ?  86  ASP A OD1 1 
ATOM   675  O OD2 . ASP A 1 122 ? 0.742   -3.690  -1.406  1.00 58.14 ?  86  ASP A OD2 1 
ATOM   676  N N   . MET A 1 123 ? 5.576   -5.414  -4.184  1.00 32.56 ?  87  MET A N   1 
ATOM   677  C CA  . MET A 1 123 ? 6.538   -6.494  -4.347  1.00 32.77 ?  87  MET A CA  1 
ATOM   678  C C   . MET A 1 123 ? 7.877   -6.214  -3.663  1.00 29.58 ?  87  MET A C   1 
ATOM   679  O O   . MET A 1 123 ? 8.398   -5.101  -3.715  1.00 26.65 ?  87  MET A O   1 
ATOM   680  C CB  . MET A 1 123 ? 6.716   -6.714  -5.836  1.00 30.18 ?  87  MET A CB  1 
ATOM   681  C CG  . MET A 1 123 ? 7.996   -7.321  -6.241  1.00 37.92 ?  87  MET A CG  1 
ATOM   682  S SD  . MET A 1 123 ? 7.500   -8.345  -7.608  1.00 55.76 ?  87  MET A SD  1 
ATOM   683  C CE  . MET A 1 123 ? 6.919   -9.686  -6.644  1.00 23.88 ?  87  MET A CE  1 
ATOM   684  N N   . LYS A 1 124 ? 8.460   -7.238  -3.032  1.00 27.97 ?  88  LYS A N   1 
ATOM   685  C CA  . LYS A 1 124 ? 9.777   -7.090  -2.411  1.00 24.68 ?  88  LYS A CA  1 
ATOM   686  C C   . LYS A 1 124 ? 10.851  -7.684  -3.312  1.00 27.04 ?  88  LYS A C   1 
ATOM   687  O O   . LYS A 1 124 ? 10.793  -8.869  -3.674  1.00 22.30 ?  88  LYS A O   1 
ATOM   688  C CB  . LYS A 1 124 ? 9.820   -7.720  -1.023  1.00 28.27 ?  88  LYS A CB  1 
ATOM   689  C CG  . LYS A 1 124 ? 8.840   -7.082  -0.044  1.00 25.38 ?  88  LYS A CG  1 
ATOM   690  C CD  . LYS A 1 124 ? 9.161   -5.630  0.240   1.00 29.93 ?  88  LYS A CD  1 
ATOM   691  C CE  . LYS A 1 124 ? 8.127   -5.028  1.194   1.00 25.92 ?  88  LYS A CE  1 
ATOM   692  N NZ  . LYS A 1 124 ? 8.667   -3.804  1.861   1.00 29.24 ?  88  LYS A NZ  1 
ATOM   693  N N   . VAL A 1 125 ? 11.829  -6.854  -3.674  1.00 22.47 ?  89  VAL A N   1 
ATOM   694  C CA  . VAL A 1 125 ? 12.932  -7.257  -4.539  1.00 23.33 ?  89  VAL A CA  1 
ATOM   695  C C   . VAL A 1 125 ? 14.234  -7.057  -3.783  1.00 23.41 ?  89  VAL A C   1 
ATOM   696  O O   . VAL A 1 125 ? 14.548  -5.938  -3.354  1.00 20.51 ?  89  VAL A O   1 
ATOM   697  C CB  . VAL A 1 125 ? 12.938  -6.475  -5.858  1.00 24.26 ?  89  VAL A CB  1 
ATOM   698  C CG1 . VAL A 1 125 ? 14.070  -6.969  -6.753  1.00 22.79 ?  89  VAL A CG1 1 
ATOM   699  C CG2 . VAL A 1 125 ? 11.590  -6.623  -6.555  1.00 21.10 ?  89  VAL A CG2 1 
ATOM   700  N N   . LEU A 1 126 ? 14.988  -8.142  -3.609  1.00 19.84 ?  90  LEU A N   1 
ATOM   701  C CA  . LEU A 1 126 ? 16.267  -8.077  -2.912  1.00 21.48 ?  90  LEU A CA  1 
ATOM   702  C C   . LEU A 1 126 ? 17.422  -7.902  -3.890  1.00 21.08 ?  90  LEU A C   1 
ATOM   703  O O   . LEU A 1 126 ? 17.453  -8.513  -4.963  1.00 22.76 ?  90  LEU A O   1 
ATOM   704  C CB  . LEU A 1 126 ? 16.501  -9.341  -2.084  1.00 19.99 ?  90  LEU A CB  1 
ATOM   705  C CG  . LEU A 1 126 ? 15.348  -9.826  -1.187  1.00 23.08 ?  90  LEU A CG  1 
ATOM   706  C CD1 . LEU A 1 126 ? 15.763  -11.096 -0.487  1.00 22.53 ?  90  LEU A CD1 1 
ATOM   707  C CD2 . LEU A 1 126 ? 14.908  -8.750  -0.175  1.00 20.13 ?  90  LEU A CD2 1 
ATOM   708  N N   . PHE A 1 127 ? 18.384  -7.075  -3.498  1.00 17.23 ?  91  PHE A N   1 
ATOM   709  C CA  . PHE A 1 127 ? 19.667  -7.008  -4.182  1.00 18.44 ?  91  PHE A CA  1 
ATOM   710  C C   . PHE A 1 127 ? 20.574  -8.130  -3.676  1.00 17.96 ?  91  PHE A C   1 
ATOM   711  O O   . PHE A 1 127 ? 20.607  -8.418  -2.478  1.00 17.30 ?  91  PHE A O   1 
ATOM   712  C CB  . PHE A 1 127 ? 20.285  -5.635  -3.926  1.00 19.69 ?  91  PHE A CB  1 
ATOM   713  C CG  . PHE A 1 127 ? 21.706  -5.493  -4.367  1.00 18.46 ?  91  PHE A CG  1 
ATOM   714  C CD1 . PHE A 1 127 ? 22.034  -5.487  -5.700  1.00 19.60 ?  91  PHE A CD1 1 
ATOM   715  C CD2 . PHE A 1 127 ? 22.707  -5.319  -3.432  1.00 21.61 ?  91  PHE A CD2 1 
ATOM   716  C CE1 . PHE A 1 127 ? 23.337  -5.332  -6.095  1.00 20.72 ?  91  PHE A CE1 1 
ATOM   717  C CE2 . PHE A 1 127 ? 24.012  -5.178  -3.817  1.00 20.40 ?  91  PHE A CE2 1 
ATOM   718  C CZ  . PHE A 1 127 ? 24.331  -5.169  -5.147  1.00 21.59 ?  91  PHE A CZ  1 
ATOM   719  N N   . TYR A 1 128 ? 21.284  -8.765  -4.592  1.00 18.31 ?  92  TYR A N   1 
ATOM   720  C CA  . TYR A 1 128 ? 22.175  -9.881  -4.206  1.00 19.82 ?  92  TYR A CA  1 
ATOM   721  C C   . TYR A 1 128 ? 23.611  -9.430  -3.964  1.00 19.05 ?  92  TYR A C   1 
ATOM   722  O O   . TYR A 1 128 ? 24.133  -8.609  -4.718  1.00 18.67 ?  92  TYR A O   1 
ATOM   723  C CB  . TYR A 1 128 ? 22.224  -10.952 -5.293  1.00 24.17 ?  92  TYR A CB  1 
ATOM   724  C CG  . TYR A 1 128 ? 23.242  -12.050 -5.101  1.00 25.05 ?  92  TYR A CG  1 
ATOM   725  C CD1 . TYR A 1 128 ? 24.590  -11.833 -5.330  1.00 18.45 ?  92  TYR A CD1 1 
ATOM   726  C CD2 . TYR A 1 128 ? 22.853  -13.324 -4.719  1.00 22.21 ?  92  TYR A CD2 1 
ATOM   727  C CE1 . TYR A 1 128 ? 25.526  -12.835 -5.152  1.00 23.83 ?  92  TYR A CE1 1 
ATOM   728  C CE2 . TYR A 1 128 ? 23.776  -14.342 -4.547  1.00 25.08 ?  92  TYR A CE2 1 
ATOM   729  C CZ  . TYR A 1 128 ? 25.118  -14.097 -4.769  1.00 24.18 ?  92  TYR A CZ  1 
ATOM   730  O OH  . TYR A 1 128 ? 26.055  -15.081 -4.605  1.00 30.43 ?  92  TYR A OH  1 
ATOM   731  N N   . PHE A 1 129 ? 24.201  -9.908  -2.881  1.00 21.70 ?  93  PHE A N   1 
ATOM   732  C CA  . PHE A 1 129 ? 25.642  -9.717  -2.713  1.00 22.40 ?  93  PHE A CA  1 
ATOM   733  C C   . PHE A 1 129 ? 26.274  -10.862 -1.937  1.00 23.34 ?  93  PHE A C   1 
ATOM   734  O O   . PHE A 1 129 ? 25.801  -11.224 -0.853  1.00 23.21 ?  93  PHE A O   1 
ATOM   735  C CB  . PHE A 1 129 ? 25.958  -8.389  -2.028  1.00 20.17 ?  93  PHE A CB  1 
ATOM   736  C CG  . PHE A 1 129 ? 27.223  -7.774  -2.521  1.00 24.91 ?  93  PHE A CG  1 
ATOM   737  C CD1 . PHE A 1 129 ? 27.318  -7.332  -3.826  1.00 24.91 ?  93  PHE A CD1 1 
ATOM   738  C CD2 . PHE A 1 129 ? 28.337  -7.691  -1.705  1.00 23.28 ?  93  PHE A CD2 1 
ATOM   739  C CE1 . PHE A 1 129 ? 28.488  -6.769  -4.295  1.00 27.15 ?  93  PHE A CE1 1 
ATOM   740  C CE2 . PHE A 1 129 ? 29.506  -7.135  -2.170  1.00 25.78 ?  93  PHE A CE2 1 
ATOM   741  C CZ  . PHE A 1 129 ? 29.584  -6.674  -3.471  1.00 23.75 ?  93  PHE A CZ  1 
ATOM   742  N N   . ASN A 1 130 ? 27.390  -11.335 -2.482  1.00 22.64 ?  94  ASN A N   1 
ATOM   743  C CA  . ASN A 1 130 ? 28.149  -12.423 -1.829  1.00 23.27 ?  94  ASN A CA  1 
ATOM   744  C C   . ASN A 1 130 ? 29.054  -11.841 -0.746  1.00 21.88 ?  94  ASN A C   1 
ATOM   745  O O   . ASN A 1 130 ? 29.756  -10.881 -1.021  1.00 19.52 ?  94  ASN A O   1 
ATOM   746  C CB  . ASN A 1 130 ? 28.946  -13.249 -2.842  1.00 21.27 ?  94  ASN A CB  1 
ATOM   747  C CG  . ASN A 1 130 ? 29.263  -14.649 -2.361  1.00 24.32 ?  94  ASN A CG  1 
ATOM   748  O OD1 . ASN A 1 130 ? 30.066  -14.833 -1.453  1.00 21.07 ?  94  ASN A OD1 1 
ATOM   749  N ND2 . ASN A 1 130 ? 28.641  -15.642 -2.971  1.00 23.82 ?  94  ASN A ND2 1 
ATOM   750  N N   . SER A 1 131 ? 29.013  -12.434 0.434   1.00 20.03 ?  95  SER A N   1 
ATOM   751  C CA  . SER A 1 131 ? 29.879  -12.025 1.522   1.00 20.39 ?  95  SER A CA  1 
ATOM   752  C C   . SER A 1 131 ? 31.265  -12.642 1.446   1.00 23.61 ?  95  SER A C   1 
ATOM   753  O O   . SER A 1 131 ? 32.124  -12.279 2.246   1.00 20.27 ?  95  SER A O   1 
ATOM   754  C CB  . SER A 1 131 ? 29.260  -12.429 2.859   1.00 25.17 ?  95  SER A CB  1 
ATOM   755  O OG  . SER A 1 131 ? 29.456  -13.825 3.057   1.00 25.09 ?  95  SER A OG  1 
ATOM   756  N N   . ALA A 1 132 ? 31.494  -13.587 0.548   1.00 18.81 ?  96  ALA A N   1 
ATOM   757  C CA  . ALA A 1 132 ? 32.725  -14.359 0.565   1.00 20.14 ?  96  ALA A CA  1 
ATOM   758  C C   . ALA A 1 132 ? 33.512  -14.222 -0.724  1.00 22.51 ?  96  ALA A C   1 
ATOM   759  O O   . ALA A 1 132 ? 34.720  -13.940 -0.690  1.00 23.25 ?  96  ALA A O   1 
ATOM   760  C CB  . ALA A 1 132 ? 32.399  -15.836 0.832   1.00 23.21 ?  96  ALA A CB  1 
ATOM   761  N N   . TYR A 1 133 ? 32.836  -14.408 -1.841  1.00 21.41 ?  97  TYR A N   1 
ATOM   762  C CA  . TYR A 1 133 ? 33.488  -14.331 -3.166  1.00 25.62 ?  97  TYR A CA  1 
ATOM   763  C C   . TYR A 1 133 ? 33.281  -12.929 -3.733  1.00 23.39 ?  97  TYR A C   1 
ATOM   764  O O   . TYR A 1 133 ? 32.163  -12.415 -3.703  1.00 22.20 ?  97  TYR A O   1 
ATOM   765  C CB  . TYR A 1 133 ? 32.985  -15.453 -4.074  1.00 26.80 ?  97  TYR A CB  1 
ATOM   766  C CG  . TYR A 1 133 ? 33.077  -16.825 -3.466  1.00 26.32 ?  97  TYR A CG  1 
ATOM   767  C CD1 . TYR A 1 133 ? 34.290  -17.485 -3.390  1.00 30.81 ?  97  TYR A CD1 1 
ATOM   768  C CD2 . TYR A 1 133 ? 31.960  -17.453 -2.948  1.00 30.33 ?  97  TYR A CD2 1 
ATOM   769  C CE1 . TYR A 1 133 ? 34.392  -18.743 -2.823  1.00 33.55 ?  97  TYR A CE1 1 
ATOM   770  C CE2 . TYR A 1 133 ? 32.044  -18.711 -2.378  1.00 30.79 ?  97  TYR A CE2 1 
ATOM   771  C CZ  . TYR A 1 133 ? 33.264  -19.357 -2.313  1.00 34.90 ?  97  TYR A CZ  1 
ATOM   772  O OH  . TYR A 1 133 ? 33.361  -20.603 -1.750  1.00 36.10 ?  97  TYR A OH  1 
ATOM   773  N N   . ALA A 1 134 ? 34.365  -12.343 -4.208  1.00 21.60 ?  98  ALA A N   1 
ATOM   774  C CA  . ALA A 1 134 ? 34.322  -10.989 -4.744  1.00 24.01 ?  98  ALA A CA  1 
ATOM   775  C C   . ALA A 1 134 ? 33.990  -11.025 -6.235  1.00 24.91 ?  98  ALA A C   1 
ATOM   776  O O   . ALA A 1 134 ? 34.747  -10.543 -7.082  1.00 24.39 ?  98  ALA A O   1 
ATOM   777  C CB  . ALA A 1 134 ? 35.647  -10.283 -4.479  1.00 20.12 ?  98  ALA A CB  1 
ATOM   778  N N   . TRP A 1 135 ? 32.817  -11.599 -6.522  1.00 23.01 ?  99  TRP A N   1 
ATOM   779  C CA  . TRP A 1 135 ? 32.317  -11.709 -7.913  1.00 25.40 ?  99  TRP A CA  1 
ATOM   780  C C   . TRP A 1 135 ? 32.450  -10.346 -8.573  1.00 28.95 ?  99  TRP A C   1 
ATOM   781  O O   . TRP A 1 135 ? 31.877  -9.389  -8.063  1.00 26.58 ?  99  TRP A O   1 
ATOM   782  C CB  . TRP A 1 135 ? 30.862  -12.197 -7.971  1.00 24.22 ?  99  TRP A CB  1 
ATOM   783  C CG  . TRP A 1 135 ? 30.591  -13.544 -7.380  1.00 24.48 ?  99  TRP A CG  1 
ATOM   784  C CD1 . TRP A 1 135 ? 29.822  -13.821 -6.288  1.00 23.82 ?  99  TRP A CD1 1 
ATOM   785  C CD2 . TRP A 1 135 ? 31.056  -14.811 -7.873  1.00 27.95 ?  99  TRP A CD2 1 
ATOM   786  N NE1 . TRP A 1 135 ? 29.785  -15.169 -6.062  1.00 28.30 ?  99  TRP A NE1 1 
ATOM   787  C CE2 . TRP A 1 135 ? 30.533  -15.802 -7.018  1.00 30.36 ?  99  TRP A CE2 1 
ATOM   788  C CE3 . TRP A 1 135 ? 31.862  -15.204 -8.946  1.00 31.98 ?  99  TRP A CE3 1 
ATOM   789  C CZ2 . TRP A 1 135 ? 30.794  -17.156 -7.206  1.00 32.25 ?  99  TRP A CZ2 1 
ATOM   790  C CZ3 . TRP A 1 135 ? 32.118  -16.543 -9.131  1.00 36.65 ?  99  TRP A CZ3 1 
ATOM   791  C CH2 . TRP A 1 135 ? 31.592  -17.505 -8.270  1.00 35.21 ?  99  TRP A CH2 1 
ATOM   792  N N   . PRO A 1 136 ? 33.187  -10.255 -9.694  1.00 30.33 ?  100 PRO A N   1 
ATOM   793  C CA  . PRO A 1 136 ? 33.426  -8.956  -10.333 1.00 30.36 ?  100 PRO A CA  1 
ATOM   794  C C   . PRO A 1 136 ? 32.258  -8.482  -11.186 1.00 33.37 ?  100 PRO A C   1 
ATOM   795  O O   . PRO A 1 136 ? 32.488  -7.824  -12.205 1.00 33.99 ?  100 PRO A O   1 
ATOM   796  C CB  . PRO A 1 136 ? 34.660  -9.236  -11.202 1.00 28.51 ?  100 PRO A CB  1 
ATOM   797  C CG  . PRO A 1 136 ? 34.477  -10.686 -11.605 1.00 28.98 ?  100 PRO A CG  1 
ATOM   798  C CD  . PRO A 1 136 ? 33.908  -11.352 -10.372 1.00 28.51 ?  100 PRO A CD  1 
ATOM   799  N N   . PHE A 1 137 ? 31.024  -8.830  -10.821 1.00 29.76 ?  101 PHE A N   1 
ATOM   800  C CA  . PHE A 1 137 ? 29.863  -8.559  -11.721 1.00 28.38 ?  101 PHE A CA  1 
ATOM   801  C C   . PHE A 1 137 ? 29.268  -7.168  -11.514 1.00 28.64 ?  101 PHE A C   1 
ATOM   802  O O   . PHE A 1 137 ? 28.725  -6.625  -12.475 1.00 27.43 ?  101 PHE A O   1 
ATOM   803  C CB  . PHE A 1 137 ? 28.816  -9.666  -11.579 1.00 28.43 ?  101 PHE A CB  1 
ATOM   804  C CG  . PHE A 1 137 ? 29.356  -11.059 -11.776 1.00 28.71 ?  101 PHE A CG  1 
ATOM   805  C CD1 . PHE A 1 137 ? 30.406  -11.297 -12.647 1.00 36.37 ?  101 PHE A CD1 1 
ATOM   806  C CD2 . PHE A 1 137 ? 28.825  -12.130 -11.080 1.00 32.04 ?  101 PHE A CD2 1 
ATOM   807  C CE1 . PHE A 1 137 ? 30.908  -12.577 -12.820 1.00 36.46 ?  101 PHE A CE1 1 
ATOM   808  C CE2 . PHE A 1 137 ? 29.329  -13.408 -11.252 1.00 27.80 ?  101 PHE A CE2 1 
ATOM   809  C CZ  . PHE A 1 137 ? 30.368  -13.629 -12.123 1.00 30.64 ?  101 PHE A CZ  1 
ATOM   810  N N   . THR A 1 138 ? 29.318  -6.661  -10.293 1.00 22.59 ?  102 THR A N   1 
ATOM   811  C CA  . THR A 1 138 ? 28.870  -5.301  -10.056 1.00 28.16 ?  102 THR A CA  1 
ATOM   812  C C   . THR A 1 138 ? 30.013  -4.324  -10.286 1.00 25.55 ?  102 THR A C   1 
ATOM   813  O O   . THR A 1 138 ? 31.183  -4.697  -10.280 1.00 26.65 ?  102 THR A O   1 
ATOM   814  C CB  . THR A 1 138 ? 28.355  -5.145  -8.628  1.00 26.00 ?  102 THR A CB  1 
ATOM   815  O OG1 . THR A 1 138 ? 29.393  -5.508  -7.707  1.00 21.30 ?  102 THR A OG1 1 
ATOM   816  C CG2 . THR A 1 138 ? 27.145  -6.034  -8.413  1.00 22.34 ?  102 THR A CG2 1 
ATOM   817  N N   . SER A 1 139 ? 29.656  -3.047  -10.468 1.00 24.83 ?  103 SER A N   1 
ATOM   818  C CA  . SER A 1 139 ? 30.670  -1.995  -10.493 1.00 27.04 ?  103 SER A CA  1 
ATOM   819  C C   . SER A 1 139 ? 31.441  -1.927  -9.178  1.00 29.33 ?  103 SER A C   1 
ATOM   820  O O   . SER A 1 139 ? 32.641  -1.614  -9.171  1.00 28.06 ?  103 SER A O   1 
ATOM   821  C CB  . SER A 1 139 ? 30.016  -0.643  -10.799 1.00 25.71 ?  103 SER A CB  1 
ATOM   822  O OG  . SER A 1 139 ? 29.097  -0.272  -9.770  1.00 24.15 ?  103 SER A OG  1 
ATOM   823  N N   . TYR A 1 140 ? 30.771  -2.213  -8.058  1.00 25.72 ?  104 TYR A N   1 
ATOM   824  C CA  . TYR A 1 140 ? 31.430  -2.144  -6.758  1.00 25.01 ?  104 TYR A CA  1 
ATOM   825  C C   . TYR A 1 140 ? 32.617  -3.083  -6.692  1.00 27.77 ?  104 TYR A C   1 
ATOM   826  O O   . TYR A 1 140 ? 33.616  -2.778  -6.037  1.00 22.52 ?  104 TYR A O   1 
ATOM   827  C CB  . TYR A 1 140 ? 30.442  -2.490  -5.648  1.00 27.45 ?  104 TYR A CB  1 
ATOM   828  C CG  . TYR A 1 140 ? 29.085  -1.882  -5.869  1.00 24.80 ?  104 TYR A CG  1 
ATOM   829  C CD1 . TYR A 1 140 ? 28.942  -0.496  -5.961  1.00 26.35 ?  104 TYR A CD1 1 
ATOM   830  C CD2 . TYR A 1 140 ? 27.942  -2.681  -5.973  1.00 24.79 ?  104 TYR A CD2 1 
ATOM   831  C CE1 . TYR A 1 140 ? 27.706  0.088   -6.161  1.00 24.35 ?  104 TYR A CE1 1 
ATOM   832  C CE2 . TYR A 1 140 ? 26.679  -2.096  -6.166  1.00 24.06 ?  104 TYR A CE2 1 
ATOM   833  C CZ  . TYR A 1 140 ? 26.583  -0.716  -6.272  1.00 25.39 ?  104 TYR A CZ  1 
ATOM   834  O OH  . TYR A 1 140 ? 25.376  -0.117  -6.484  1.00 24.52 ?  104 TYR A OH  1 
ATOM   835  N N   . ASN A 1 141 ? 32.526  -4.220  -7.372  1.00 29.17 ?  105 ASN A N   1 
ATOM   836  C CA  . ASN A 1 141 ? 33.558  -5.240  -7.362  1.00 26.39 ?  105 ASN A CA  1 
ATOM   837  C C   . ASN A 1 141 ? 34.395  -5.236  -8.639  1.00 27.16 ?  105 ASN A C   1 
ATOM   838  O O   . ASN A 1 141 ? 35.118  -6.200  -8.898  1.00 25.59 ?  105 ASN A O   1 
ATOM   839  C CB  . ASN A 1 141 ? 32.910  -6.610  -7.162  1.00 22.73 ?  105 ASN A CB  1 
ATOM   840  C CG  . ASN A 1 141 ? 32.471  -6.861  -5.716  1.00 23.58 ?  105 ASN A CG  1 
ATOM   841  O OD1 . ASN A 1 141 ? 32.568  -5.985  -4.853  1.00 20.70 ?  105 ASN A OD1 1 
ATOM   842  N ND2 . ASN A 1 141 ? 31.996  -8.076  -5.453  1.00 21.16 ?  105 ASN A ND2 1 
ATOM   843  N N   . GLN A 1 142 ? 34.317  -4.178  -9.445  1.00 31.34 ?  106 GLN A N   1 
ATOM   844  C CA  . GLN A 1 142 ? 34.966  -4.217  -10.751 1.00 32.75 ?  106 GLN A CA  1 
ATOM   845  C C   . GLN A 1 142 ? 36.485  -4.311  -10.652 1.00 34.57 ?  106 GLN A C   1 
ATOM   846  O O   . GLN A 1 142 ? 37.126  -4.747  -11.614 1.00 37.36 ?  106 GLN A O   1 
ATOM   847  C CB  . GLN A 1 142 ? 34.557  -2.996  -11.576 1.00 32.85 ?  106 GLN A CB  1 
ATOM   848  C CG  . GLN A 1 142 ? 35.557  -1.866  -11.566 1.00 39.28 ?  106 GLN A CG  1 
ATOM   849  C CD  . GLN A 1 142 ? 35.217  -0.786  -12.583 1.00 54.39 ?  106 GLN A CD  1 
ATOM   850  O OE1 . GLN A 1 142 ? 35.661  -0.839  -13.733 1.00 58.89 ?  106 GLN A OE1 1 
ATOM   851  N NE2 . GLN A 1 142 ? 34.422  0.197   -12.164 1.00 51.37 ?  106 GLN A NE2 1 
ATOM   852  N N   . ALA A 1 143 ? 37.073  -3.951  -9.509  1.00 33.01 ?  107 ALA A N   1 
ATOM   853  C CA  . ALA A 1 143 ? 38.519  -4.004  -9.353  1.00 33.90 ?  107 ALA A CA  1 
ATOM   854  C C   . ALA A 1 143 ? 39.029  -5.376  -8.934  1.00 33.49 ?  107 ALA A C   1 
ATOM   855  O O   . ALA A 1 143 ? 40.239  -5.615  -9.009  1.00 35.08 ?  107 ALA A O   1 
ATOM   856  C CB  . ALA A 1 143 ? 38.983  -2.971  -8.332  1.00 29.83 ?  107 ALA A CB  1 
ATOM   857  N N   . PHE A 1 144 ? 38.148  -6.274  -8.489  1.00 30.66 ?  108 PHE A N   1 
ATOM   858  C CA  . PHE A 1 144 ? 38.557  -7.597  -8.028  1.00 29.09 ?  108 PHE A CA  1 
ATOM   859  C C   . PHE A 1 144 ? 38.700  -8.549  -9.218  1.00 31.76 ?  108 PHE A C   1 
ATOM   860  O O   . PHE A 1 144 ? 37.991  -9.544  -9.357  1.00 28.74 ?  108 PHE A O   1 
ATOM   861  C CB  . PHE A 1 144 ? 37.568  -8.135  -7.001  1.00 26.59 ?  108 PHE A CB  1 
ATOM   862  C CG  . PHE A 1 144 ? 37.461  -7.295  -5.763  1.00 26.96 ?  108 PHE A CG  1 
ATOM   863  C CD1 . PHE A 1 144 ? 38.529  -7.190  -4.879  1.00 25.62 ?  108 PHE A CD1 1 
ATOM   864  C CD2 . PHE A 1 144 ? 36.301  -6.581  -5.491  1.00 23.91 ?  108 PHE A CD2 1 
ATOM   865  C CE1 . PHE A 1 144 ? 38.439  -6.404  -3.736  1.00 22.23 ?  108 PHE A CE1 1 
ATOM   866  C CE2 . PHE A 1 144 ? 36.201  -5.807  -4.350  1.00 23.41 ?  108 PHE A CE2 1 
ATOM   867  C CZ  . PHE A 1 144 ? 37.278  -5.715  -3.471  1.00 23.06 ?  108 PHE A CZ  1 
ATOM   868  N N   . THR A 1 145 ? 39.634  -8.206  -10.101 1.00 33.37 ?  109 THR A N   1 
ATOM   869  C CA  . THR A 1 145 ? 40.082  -9.101  -11.156 1.00 34.88 ?  109 THR A CA  1 
ATOM   870  C C   . THR A 1 145 ? 41.598  -9.194  -11.096 1.00 37.58 ?  109 THR A C   1 
ATOM   871  O O   . THR A 1 145 ? 42.277  -8.318  -10.551 1.00 38.10 ?  109 THR A O   1 
ATOM   872  C CB  . THR A 1 145 ? 39.634  -8.646  -12.559 1.00 35.55 ?  109 THR A CB  1 
ATOM   873  O OG1 . THR A 1 145 ? 40.408  -7.517  -12.971 1.00 43.26 ?  109 THR A OG1 1 
ATOM   874  C CG2 . THR A 1 145 ? 38.158  -8.262  -12.569 1.00 28.96 ?  109 THR A CG2 1 
ATOM   875  N N   . ARG A 1 146 ? 42.122  -10.274 -11.679 1.00 40.69 ?  110 ARG A N   1 
ATOM   876  C CA  . ARG A 1 146 ? 43.559  -10.531 -11.627 1.00 47.48 ?  110 ARG A CA  1 
ATOM   877  C C   . ARG A 1 146 ? 44.382  -9.354  -12.152 1.00 47.22 ?  110 ARG A C   1 
ATOM   878  O O   . ARG A 1 146 ? 45.437  -9.028  -11.596 1.00 49.56 ?  110 ARG A O   1 
ATOM   879  C CB  . ARG A 1 146 ? 43.875  -11.801 -12.413 1.00 42.97 ?  110 ARG A CB  1 
ATOM   880  C CG  . ARG A 1 146 ? 45.343  -12.026 -12.626 1.00 50.57 ?  110 ARG A CG  1 
ATOM   881  C CD  . ARG A 1 146 ? 45.956  -12.700 -11.426 1.00 51.05 ?  110 ARG A CD  1 
ATOM   882  N NE  . ARG A 1 146 ? 45.147  -13.825 -10.983 1.00 43.96 ?  110 ARG A NE  1 
ATOM   883  C CZ  . ARG A 1 146 ? 45.202  -14.346 -9.765  1.00 46.40 ?  110 ARG A CZ  1 
ATOM   884  N NH1 . ARG A 1 146 ? 45.995  -13.837 -8.832  1.00 46.13 ?  110 ARG A NH1 1 
ATOM   885  N NH2 . ARG A 1 146 ? 44.452  -15.409 -9.478  1.00 40.12 ?  110 ARG A NH2 1 
ATOM   886  N N   . ASN A 1 147 ? 43.907  -8.688  -13.204 1.00 46.16 ?  111 ASN A N   1 
ATOM   887  C CA  . ASN A 1 147 ? 44.686  -7.666  -13.893 1.00 47.90 ?  111 ASN A CA  1 
ATOM   888  C C   . ASN A 1 147 ? 44.367  -6.246  -13.441 1.00 49.00 ?  111 ASN A C   1 
ATOM   889  O O   . ASN A 1 147 ? 44.863  -5.293  -14.053 1.00 49.33 ?  111 ASN A O   1 
ATOM   890  C CB  . ASN A 1 147 ? 44.479  -7.767  -15.406 1.00 51.79 ?  111 ASN A CB  1 
ATOM   891  C CG  . ASN A 1 147 ? 43.044  -8.086  -15.777 1.00 58.77 ?  111 ASN A CG  1 
ATOM   892  O OD1 . ASN A 1 147 ? 42.447  -9.050  -15.268 1.00 58.74 ?  111 ASN A OD1 1 
ATOM   893  N ND2 . ASN A 1 147 ? 42.470  -7.269  -16.664 1.00 56.62 ?  111 ASN A ND2 1 
ATOM   894  N N   . LYS A 1 148 ? 43.538  -6.069  -12.410 1.00 48.00 ?  112 LYS A N   1 
ATOM   895  C CA  . LYS A 1 148 ? 43.289  -4.736  -11.868 1.00 41.41 ?  112 LYS A CA  1 
ATOM   896  C C   . LYS A 1 148 ? 43.493  -4.617  -10.369 1.00 39.86 ?  112 LYS A C   1 
ATOM   897  O O   . LYS A 1 148 ? 43.635  -3.486  -9.886  1.00 38.34 ?  112 LYS A O   1 
ATOM   898  C CB  . LYS A 1 148 ? 41.867  -4.261  -12.202 1.00 38.63 ?  112 LYS A CB  1 
ATOM   899  C CG  . LYS A 1 148 ? 41.599  -4.080  -13.678 1.00 45.00 ?  112 LYS A CG  1 
ATOM   900  C CD  . LYS A 1 148 ? 40.223  -3.481  -13.934 1.00 45.79 ?  112 LYS A CD  1 
ATOM   901  C CE  . LYS A 1 148 ? 39.174  -4.582  -14.074 1.00 49.07 ?  112 LYS A CE  1 
ATOM   902  N NZ  . LYS A 1 148 ? 39.695  -5.811  -14.766 1.00 47.65 ?  112 LYS A NZ  1 
ATOM   903  N N   . ILE A 1 149 ? 43.537  -5.723  -9.618  1.00 34.62 ?  113 ILE A N   1 
ATOM   904  C CA  . ILE A 1 149 ? 43.472  -5.615  -8.162  1.00 36.85 ?  113 ILE A CA  1 
ATOM   905  C C   . ILE A 1 149 ? 44.710  -4.920  -7.608  1.00 39.27 ?  113 ILE A C   1 
ATOM   906  O O   . ILE A 1 149 ? 44.618  -4.141  -6.648  1.00 35.89 ?  113 ILE A O   1 
ATOM   907  C CB  . ILE A 1 149 ? 43.257  -6.997  -7.517  1.00 35.47 ?  113 ILE A CB  1 
ATOM   908  C CG1 . ILE A 1 149 ? 43.150  -6.857  -5.999  1.00 32.44 ?  113 ILE A CG1 1 
ATOM   909  C CG2 . ILE A 1 149 ? 44.378  -7.982  -7.905  1.00 37.36 ?  113 ILE A CG2 1 
ATOM   910  C CD1 . ILE A 1 149 ? 42.057  -5.915  -5.544  1.00 34.83 ?  113 ILE A CD1 1 
ATOM   911  N N   . ASP A 1 150 ? 45.885  -5.173  -8.206  1.00 40.76 ?  114 ASP A N   1 
ATOM   912  C CA  . ASP A 1 150 ? 47.113  -4.555  -7.707  1.00 42.49 ?  114 ASP A CA  1 
ATOM   913  C C   . ASP A 1 150 ? 47.031  -3.037  -7.755  1.00 37.87 ?  114 ASP A C   1 
ATOM   914  O O   . ASP A 1 150 ? 47.627  -2.359  -6.913  1.00 43.60 ?  114 ASP A O   1 
ATOM   915  C CB  . ASP A 1 150 ? 48.324  -5.036  -8.506  1.00 39.61 ?  114 ASP A CB  1 
ATOM   916  C CG  . ASP A 1 150 ? 48.698  -6.466  -8.192  1.00 43.77 ?  114 ASP A CG  1 
ATOM   917  O OD1 . ASP A 1 150 ? 48.069  -7.080  -7.310  1.00 46.82 ?  114 ASP A OD1 1 
ATOM   918  O OD2 . ASP A 1 150 ? 49.628  -6.983  -8.832  1.00 43.60 ?  114 ASP A OD2 1 
ATOM   919  N N   . GLU A 1 151 ? 46.290  -2.490  -8.721  1.00 39.79 ?  115 GLU A N   1 
ATOM   920  C CA  . GLU A 1 151 ? 46.063  -1.057  -8.856  1.00 38.60 ?  115 GLU A CA  1 
ATOM   921  C C   . GLU A 1 151 ? 45.123  -0.502  -7.792  1.00 39.23 ?  115 GLU A C   1 
ATOM   922  O O   . GLU A 1 151 ? 44.917  0.716   -7.748  1.00 41.45 ?  115 GLU A O   1 
ATOM   923  C CB  . GLU A 1 151 ? 45.502  -0.752  -10.249 1.00 44.37 ?  115 GLU A CB  1 
ATOM   924  C CG  . GLU A 1 151 ? 46.535  -0.818  -11.367 1.00 50.08 ?  115 GLU A CG  1 
ATOM   925  C CD  . GLU A 1 151 ? 47.761  0.040   -11.085 1.00 57.34 ?  115 GLU A CD  1 
ATOM   926  O OE1 . GLU A 1 151 ? 47.671  1.280   -11.242 1.00 59.82 ?  115 GLU A OE1 1 
ATOM   927  O OE2 . GLU A 1 151 ? 48.814  -0.522  -10.696 1.00 60.40 ?  115 GLU A OE2 1 
ATOM   928  N N   . HIS A 1 152 ? 44.542  -1.351  -6.947  1.00 39.16 ?  116 HIS A N   1 
ATOM   929  C CA  . HIS A 1 152 ? 43.677  -0.927  -5.844  1.00 35.44 ?  116 HIS A CA  1 
ATOM   930  C C   . HIS A 1 152 ? 44.177  -1.560  -4.552  1.00 35.35 ?  116 HIS A C   1 
ATOM   931  O O   . HIS A 1 152 ? 43.571  -2.511  -4.037  1.00 39.60 ?  116 HIS A O   1 
ATOM   932  C CB  . HIS A 1 152 ? 42.224  -1.322  -6.104  1.00 34.38 ?  116 HIS A CB  1 
ATOM   933  C CG  . HIS A 1 152 ? 41.654  -0.770  -7.374  1.00 30.74 ?  116 HIS A CG  1 
ATOM   934  N ND1 . HIS A 1 152 ? 41.904  -1.327  -8.608  1.00 30.99 ?  116 HIS A ND1 1 
ATOM   935  C CD2 . HIS A 1 152 ? 40.792  0.251   -7.590  1.00 32.91 ?  116 HIS A CD2 1 
ATOM   936  C CE1 . HIS A 1 152 ? 41.243  -0.655  -9.534  1.00 35.83 ?  116 HIS A CE1 1 
ATOM   937  N NE2 . HIS A 1 152 ? 40.559  0.308   -8.942  1.00 36.44 ?  116 HIS A NE2 1 
ATOM   938  N N   . PRO A 1 153 ? 45.294  -1.062  -4.005  1.00 38.59 ?  117 PRO A N   1 
ATOM   939  C CA  . PRO A 1 153 ? 45.886  -1.721  -2.823  1.00 34.44 ?  117 PRO A CA  1 
ATOM   940  C C   . PRO A 1 153 ? 44.960  -1.796  -1.617  1.00 31.96 ?  117 PRO A C   1 
ATOM   941  O O   . PRO A 1 153 ? 44.984  -2.804  -0.898  1.00 28.14 ?  117 PRO A O   1 
ATOM   942  C CB  . PRO A 1 153 ? 47.135  -0.870  -2.526  1.00 33.47 ?  117 PRO A CB  1 
ATOM   943  C CG  . PRO A 1 153 ? 47.017  0.355   -3.393  1.00 33.47 ?  117 PRO A CG  1 
ATOM   944  C CD  . PRO A 1 153 ? 46.164  -0.005  -4.552  1.00 38.26 ?  117 PRO A CD  1 
ATOM   945  N N   . LYS A 1 154 ? 44.149  -0.765  -1.360  1.00 29.06 ?  118 LYS A N   1 
ATOM   946  C CA  . LYS A 1 154 ? 43.259  -0.833  -0.204  1.00 33.48 ?  118 LYS A CA  1 
ATOM   947  C C   . LYS A 1 154 ? 42.286  -1.999  -0.344  1.00 30.63 ?  118 LYS A C   1 
ATOM   948  O O   . LYS A 1 154 ? 42.092  -2.773  0.599   1.00 30.31 ?  118 LYS A O   1 
ATOM   949  C CB  . LYS A 1 154 ? 42.510  0.489   -0.023  1.00 34.20 ?  118 LYS A CB  1 
ATOM   950  C CG  . LYS A 1 154 ? 41.641  0.550   1.231   1.00 28.58 ?  118 LYS A CG  1 
ATOM   951  C CD  . LYS A 1 154 ? 42.336  -0.074  2.437   1.00 32.59 ?  118 LYS A CD  1 
ATOM   952  C CE  . LYS A 1 154 ? 42.676  0.965   3.487   1.00 36.52 ?  118 LYS A CE  1 
ATOM   953  N NZ  . LYS A 1 154 ? 43.501  0.403   4.617   1.00 40.41 ?  118 LYS A NZ  1 
ATOM   954  N N   . LEU A 1 155 ? 41.714  -2.173  -1.533  1.00 29.10 ?  119 LEU A N   1 
ATOM   955  C CA  . LEU A 1 155 ? 40.788  -3.278  -1.752  1.00 27.79 ?  119 LEU A CA  1 
ATOM   956  C C   . LEU A 1 155 ? 41.508  -4.616  -1.722  1.00 30.36 ?  119 LEU A C   1 
ATOM   957  O O   . LEU A 1 155 ? 40.954  -5.616  -1.242  1.00 26.60 ?  119 LEU A O   1 
ATOM   958  C CB  . LEU A 1 155 ? 40.054  -3.089  -3.075  1.00 27.59 ?  119 LEU A CB  1 
ATOM   959  C CG  . LEU A 1 155 ? 39.188  -1.827  -3.088  1.00 30.58 ?  119 LEU A CG  1 
ATOM   960  C CD1 . LEU A 1 155 ? 38.560  -1.603  -4.458  1.00 30.13 ?  119 LEU A CD1 1 
ATOM   961  C CD2 . LEU A 1 155 ? 38.123  -1.934  -2.009  1.00 23.81 ?  119 LEU A CD2 1 
ATOM   962  N N   . LYS A 1 156 ? 42.743  -4.657  -2.227  1.00 29.13 ?  120 LYS A N   1 
ATOM   963  C CA  . LYS A 1 156 ? 43.515  -5.895  -2.178  1.00 29.84 ?  120 LYS A CA  1 
ATOM   964  C C   . LYS A 1 156 ? 43.755  -6.349  -0.746  1.00 29.02 ?  120 LYS A C   1 
ATOM   965  O O   . LYS A 1 156 ? 43.779  -7.553  -0.474  1.00 30.78 ?  120 LYS A O   1 
ATOM   966  C CB  . LYS A 1 156 ? 44.839  -5.709  -2.920  1.00 34.94 ?  120 LYS A CB  1 
ATOM   967  C CG  . LYS A 1 156 ? 45.663  -6.987  -3.090  1.00 33.09 ?  120 LYS A CG  1 
ATOM   968  C CD  . LYS A 1 156 ? 47.023  -6.660  -3.676  1.00 38.71 ?  120 LYS A CD  1 
ATOM   969  C CE  . LYS A 1 156 ? 47.701  -7.913  -4.192  1.00 45.79 ?  120 LYS A CE  1 
ATOM   970  N NZ  . LYS A 1 156 ? 48.943  -7.617  -4.952  1.00 43.66 ?  120 LYS A NZ  1 
ATOM   971  N N   . SER A 1 157 ? 43.924  -5.406  0.182   1.00 28.93 ?  121 SER A N   1 
ATOM   972  C CA  . SER A 1 157 ? 44.171  -5.745  1.579   1.00 29.82 ?  121 SER A CA  1 
ATOM   973  C C   . SER A 1 157 ? 42.950  -6.345  2.267   1.00 26.72 ?  121 SER A C   1 
ATOM   974  O O   . SER A 1 157 ? 43.072  -6.853  3.387   1.00 29.70 ?  121 SER A O   1 
ATOM   975  C CB  . SER A 1 157 ? 44.627  -4.491  2.334   1.00 31.49 ?  121 SER A CB  1 
ATOM   976  O OG  . SER A 1 157 ? 43.548  -3.584  2.471   1.00 31.48 ?  121 SER A OG  1 
ATOM   977  N N   . PHE A 1 158 ? 41.779  -6.270  1.640   1.00 28.38 ?  122 PHE A N   1 
ATOM   978  C CA  . PHE A 1 158 ? 40.541  -6.826  2.172   1.00 25.06 ?  122 PHE A CA  1 
ATOM   979  C C   . PHE A 1 158 ? 40.425  -8.328  1.923   1.00 25.45 ?  122 PHE A C   1 
ATOM   980  O O   . PHE A 1 158 ? 39.463  -8.947  2.388   1.00 22.73 ?  122 PHE A O   1 
ATOM   981  C CB  . PHE A 1 158 ? 39.334  -6.122  1.520   1.00 26.62 ?  122 PHE A CB  1 
ATOM   982  C CG  . PHE A 1 158 ? 39.199  -4.641  1.853   1.00 25.89 ?  122 PHE A CG  1 
ATOM   983  C CD1 . PHE A 1 158 ? 39.994  -4.034  2.801   1.00 24.27 ?  122 PHE A CD1 1 
ATOM   984  C CD2 . PHE A 1 158 ? 38.249  -3.871  1.204   1.00 25.95 ?  122 PHE A CD2 1 
ATOM   985  C CE1 . PHE A 1 158 ? 39.842  -2.678  3.094   1.00 29.11 ?  122 PHE A CE1 1 
ATOM   986  C CE2 . PHE A 1 158 ? 38.094  -2.527  1.492   1.00 24.90 ?  122 PHE A CE2 1 
ATOM   987  C CZ  . PHE A 1 158 ? 38.888  -1.931  2.440   1.00 24.68 ?  122 PHE A CZ  1 
ATOM   988  N N   . LEU A 1 159 ? 41.374  -8.913  1.190   1.00 25.82 ?  123 LEU A N   1 
ATOM   989  C CA  . LEU A 1 159 ? 41.244  -10.239 0.610   1.00 26.75 ?  123 LEU A CA  1 
ATOM   990  C C   . LEU A 1 159 ? 42.149  -11.234 1.314   1.00 25.63 ?  123 LEU A C   1 
ATOM   991  O O   . LEU A 1 159 ? 43.245  -10.894 1.755   1.00 29.85 ?  123 LEU A O   1 
ATOM   992  C CB  . LEU A 1 159 ? 41.584  -10.225 -0.882  1.00 25.40 ?  123 LEU A CB  1 
ATOM   993  C CG  . LEU A 1 159 ? 40.819  -9.207  -1.702  1.00 27.09 ?  123 LEU A CG  1 
ATOM   994  C CD1 . LEU A 1 159 ? 41.421  -9.056  -3.083  1.00 23.32 ?  123 LEU A CD1 1 
ATOM   995  C CD2 . LEU A 1 159 ? 39.376  -9.650  -1.786  1.00 22.02 ?  123 LEU A CD2 1 
ATOM   996  N N   . ILE A 1 160 ? 41.661  -12.470 1.408   1.00 24.54 ?  124 ILE A N   1 
ATOM   997  C CA  . ILE A 1 160 ? 42.404  -13.554 2.040   1.00 30.44 ?  124 ILE A CA  1 
ATOM   998  C C   . ILE A 1 160 ? 43.610  -13.909 1.181   1.00 32.52 ?  124 ILE A C   1 
ATOM   999  O O   . ILE A 1 160 ? 43.498  -14.096 -0.042  1.00 31.32 ?  124 ILE A O   1 
ATOM   1000 C CB  . ILE A 1 160 ? 41.494  -14.776 2.246   1.00 30.35 ?  124 ILE A CB  1 
ATOM   1001 C CG1 . ILE A 1 160 ? 40.245  -14.389 3.040   1.00 25.76 ?  124 ILE A CG1 1 
ATOM   1002 C CG2 . ILE A 1 160 ? 42.255  -15.932 2.911   1.00 28.29 ?  124 ILE A CG2 1 
ATOM   1003 C CD1 . ILE A 1 160 ? 39.440  -15.570 3.552   1.00 28.06 ?  124 ILE A CD1 1 
ATOM   1004 N N   . VAL A 1 161 ? 44.763  -14.011 1.811   1.00 30.03 ?  125 VAL A N   1 
ATOM   1005 C CA  . VAL A 1 161 ? 45.968  -14.445 1.123   1.00 31.74 ?  125 VAL A CA  1 
ATOM   1006 C C   . VAL A 1 161 ? 46.154  -15.935 1.372   1.00 36.03 ?  125 VAL A C   1 
ATOM   1007 O O   . VAL A 1 161 ? 45.968  -16.428 2.494   1.00 37.71 ?  125 VAL A O   1 
ATOM   1008 C CB  . VAL A 1 161 ? 47.193  -13.628 1.573   1.00 34.22 ?  125 VAL A CB  1 
ATOM   1009 C CG1 . VAL A 1 161 ? 47.070  -12.208 1.057   1.00 35.29 ?  125 VAL A CG1 1 
ATOM   1010 C CG2 . VAL A 1 161 ? 47.304  -13.621 3.082   1.00 41.09 ?  125 VAL A CG2 1 
ATOM   1011 N N   . ASP A 1 162 ? 46.472  -16.655 0.315   1.00 38.44 ?  126 ASP A N   1 
ATOM   1012 C CA  . ASP A 1 162 ? 46.759  -18.078 0.381   1.00 38.80 ?  126 ASP A CA  1 
ATOM   1013 C C   . ASP A 1 162 ? 48.129  -18.289 1.011   1.00 38.92 ?  126 ASP A C   1 
ATOM   1014 O O   . ASP A 1 162 ? 49.137  -17.947 0.381   1.00 42.58 ?  126 ASP A O   1 
ATOM   1015 C CB  . ASP A 1 162 ? 46.712  -18.664 -1.032  1.00 39.35 ?  126 ASP A CB  1 
ATOM   1016 C CG  . ASP A 1 162 ? 46.923  -20.168 -1.059  1.00 40.46 ?  126 ASP A CG  1 
ATOM   1017 O OD1 . ASP A 1 162 ? 47.162  -20.761 0.018   1.00 36.00 ?  126 ASP A OD1 1 
ATOM   1018 O OD2 . ASP A 1 162 ? 46.846  -20.749 -2.165  1.00 37.40 ?  126 ASP A OD2 1 
ATOM   1019 N N   . PRO A 1 163 ? 48.224  -18.848 2.220   1.00 40.23 ?  127 PRO A N   1 
ATOM   1020 C CA  . PRO A 1 163 ? 49.545  -18.976 2.869   1.00 42.32 ?  127 PRO A CA  1 
ATOM   1021 C C   . PRO A 1 163 ? 50.546  -19.811 2.080   1.00 47.27 ?  127 PRO A C   1 
ATOM   1022 O O   . PRO A 1 163 ? 51.752  -19.530 2.115   1.00 42.29 ?  127 PRO A O   1 
ATOM   1023 C CB  . PRO A 1 163 ? 49.208  -19.635 4.216   1.00 44.11 ?  127 PRO A CB  1 
ATOM   1024 C CG  . PRO A 1 163 ? 47.900  -20.358 3.968   1.00 40.81 ?  127 PRO A CG  1 
ATOM   1025 C CD  . PRO A 1 163 ? 47.148  -19.444 3.027   1.00 38.70 ?  127 PRO A CD  1 
ATOM   1026 N N   . LYS A 1 164 ? 50.097  -20.837 1.367   1.00 45.05 ?  128 LYS A N   1 
ATOM   1027 C CA  . LYS A 1 164 ? 51.057  -21.624 0.611   1.00 41.69 ?  128 LYS A CA  1 
ATOM   1028 C C   . LYS A 1 164 ? 51.518  -20.926 -0.661  1.00 44.01 ?  128 LYS A C   1 
ATOM   1029 O O   . LYS A 1 164 ? 52.304  -21.510 -1.406  1.00 39.31 ?  128 LYS A O   1 
ATOM   1030 C CB  . LYS A 1 164 ? 50.485  -23.012 0.293   1.00 43.59 ?  128 LYS A CB  1 
ATOM   1031 C CG  . LYS A 1 164 ? 48.983  -23.091 0.324   1.00 39.91 ?  128 LYS A CG  1 
ATOM   1032 C CD  . LYS A 1 164 ? 48.451  -24.447 -0.052  1.00 35.75 ?  128 LYS A CD  1 
ATOM   1033 C CE  . LYS A 1 164 ? 48.021  -25.231 1.175   1.00 37.15 ?  128 LYS A CE  1 
ATOM   1034 N NZ  . LYS A 1 164 ? 46.912  -26.173 0.856   1.00 34.15 ?  128 LYS A NZ  1 
ATOM   1035 N N   . THR A 1 165 ? 51.082  -19.690 -0.920  1.00 42.48 ?  129 THR A N   1 
ATOM   1036 C CA  . THR A 1 165 ? 51.599  -18.938 -2.054  1.00 42.94 ?  129 THR A CA  1 
ATOM   1037 C C   . THR A 1 165 ? 52.010  -17.504 -1.733  1.00 45.08 ?  129 THR A C   1 
ATOM   1038 O O   . THR A 1 165 ? 52.666  -16.878 -2.574  1.00 42.56 ?  129 THR A O   1 
ATOM   1039 C CB  . THR A 1 165 ? 50.564  -18.894 -3.189  1.00 43.44 ?  129 THR A CB  1 
ATOM   1040 O OG1 . THR A 1 165 ? 49.342  -18.333 -2.688  1.00 47.69 ?  129 THR A OG1 1 
ATOM   1041 C CG2 . THR A 1 165 ? 50.298  -20.286 -3.731  1.00 40.42 ?  129 THR A CG2 1 
ATOM   1042 N N   . ALA A 1 166 ? 51.649  -16.967 -0.558  1.00 43.48 ?  130 ALA A N   1 
ATOM   1043 C CA  . ALA A 1 166 ? 51.711  -15.528 -0.253  1.00 45.96 ?  130 ALA A CA  1 
ATOM   1044 C C   . ALA A 1 166 ? 51.008  -14.698 -1.331  1.00 43.95 ?  130 ALA A C   1 
ATOM   1045 O O   . ALA A 1 166 ? 51.224  -13.487 -1.452  1.00 43.99 ?  130 ALA A O   1 
ATOM   1046 C CB  . ALA A 1 166 ? 53.155  -15.049 -0.050  1.00 42.51 ?  130 ALA A CB  1 
ATOM   1047 N N   . GLU A 1 167 ? 50.163  -15.368 -2.100  1.00 41.92 ?  131 GLU A N   1 
ATOM   1048 C CA  . GLU A 1 167 ? 49.385  -14.844 -3.205  1.00 43.44 ?  131 GLU A CA  1 
ATOM   1049 C C   . GLU A 1 167 ? 47.923  -14.783 -2.779  1.00 39.99 ?  131 GLU A C   1 
ATOM   1050 O O   . GLU A 1 167 ? 47.502  -15.474 -1.841  1.00 38.24 ?  131 GLU A O   1 
ATOM   1051 C CB  . GLU A 1 167 ? 49.546  -15.767 -4.421  1.00 50.34 ?  131 GLU A CB  1 
ATOM   1052 C CG  . GLU A 1 167 ? 49.347  -15.196 -5.812  1.00 52.32 ?  131 GLU A CG  1 
ATOM   1053 C CD  . GLU A 1 167 ? 49.419  -16.314 -6.856  1.00 60.96 ?  131 GLU A CD  1 
ATOM   1054 O OE1 . GLU A 1 167 ? 50.367  -17.132 -6.764  1.00 60.53 ?  131 GLU A OE1 1 
ATOM   1055 O OE2 . GLU A 1 167 ? 48.531  -16.394 -7.747  1.00 59.59 ?  131 GLU A OE2 1 
ATOM   1056 N N   . LEU A 1 168 ? 47.147  -13.958 -3.481  1.00 34.61 ?  132 LEU A N   1 
ATOM   1057 C CA  . LEU A 1 168 ? 45.715  -13.885 -3.217  1.00 36.86 ?  132 LEU A CA  1 
ATOM   1058 C C   . LEU A 1 168 ? 45.074  -15.250 -3.410  1.00 33.00 ?  132 LEU A C   1 
ATOM   1059 O O   . LEU A 1 168 ? 45.215  -15.866 -4.471  1.00 36.04 ?  132 LEU A O   1 
ATOM   1060 C CB  . LEU A 1 168 ? 45.059  -12.877 -4.149  1.00 34.76 ?  132 LEU A CB  1 
ATOM   1061 C CG  . LEU A 1 168 ? 45.468  -11.437 -3.931  1.00 30.48 ?  132 LEU A CG  1 
ATOM   1062 C CD1 . LEU A 1 168 ? 44.708  -10.575 -4.912  1.00 30.76 ?  132 LEU A CD1 1 
ATOM   1063 C CD2 . LEU A 1 168 ? 45.161  -11.064 -2.505  1.00 31.39 ?  132 LEU A CD2 1 
ATOM   1064 N N   . ALA A 1 169 ? 44.383  -15.734 -2.386  1.00 31.37 ?  133 ALA A N   1 
ATOM   1065 C CA  . ALA A 1 169 ? 43.559  -16.916 -2.583  1.00 33.63 ?  133 ALA A CA  1 
ATOM   1066 C C   . ALA A 1 169 ? 42.488  -16.612 -3.627  1.00 36.79 ?  133 ALA A C   1 
ATOM   1067 O O   . ALA A 1 169 ? 42.105  -15.455 -3.840  1.00 31.69 ?  133 ALA A O   1 
ATOM   1068 C CB  . ALA A 1 169 ? 42.913  -17.350 -1.267  1.00 34.79 ?  133 ALA A CB  1 
ATOM   1069 N N   . HIS A 1 170 ? 42.010  -17.653 -4.300  1.00 33.51 ?  134 HIS A N   1 
ATOM   1070 C CA  . HIS A 1 170 ? 41.015  -17.417 -5.333  1.00 36.17 ?  134 HIS A CA  1 
ATOM   1071 C C   . HIS A 1 170 ? 40.376  -18.734 -5.737  1.00 37.08 ?  134 HIS A C   1 
ATOM   1072 O O   . HIS A 1 170 ? 40.921  -19.820 -5.504  1.00 34.03 ?  134 HIS A O   1 
ATOM   1073 C CB  . HIS A 1 170 ? 41.616  -16.726 -6.564  1.00 36.18 ?  134 HIS A CB  1 
ATOM   1074 C CG  . HIS A 1 170 ? 42.647  -17.546 -7.277  1.00 38.66 ?  134 HIS A CG  1 
ATOM   1075 N ND1 . HIS A 1 170 ? 42.365  -18.271 -8.413  1.00 37.41 ?  134 HIS A ND1 1 
ATOM   1076 C CD2 . HIS A 1 170 ? 43.962  -17.739 -7.024  1.00 39.21 ?  134 HIS A CD2 1 
ATOM   1077 C CE1 . HIS A 1 170 ? 43.461  -18.878 -8.829  1.00 42.36 ?  134 HIS A CE1 1 
ATOM   1078 N NE2 . HIS A 1 170 ? 44.443  -18.577 -8.000  1.00 44.60 ?  134 HIS A NE2 1 
ATOM   1079 N N   . ARG A 1 171 ? 39.232  -18.571 -6.405  1.00 38.21 ?  135 ARG A N   1 
ATOM   1080 C CA  . ARG A 1 171 ? 38.511  -19.708 -7.016  1.00 37.18 ?  135 ARG A CA  1 
ATOM   1081 C C   . ARG A 1 171 ? 38.281  -19.246 -8.452  1.00 35.38 ?  135 ARG A C   1 
ATOM   1082 O O   . ARG A 1 171 ? 37.472  -18.351 -8.642  1.00 37.13 ?  135 ARG A O   1 
ATOM   1083 C CB  . ARG A 1 171 ? 37.193  -19.979 -6.304  1.00 33.28 ?  135 ARG A CB  1 
ATOM   1084 C CG  . ARG A 1 171 ? 36.256  -20.899 -7.068  1.00 40.89 ?  135 ARG A CG  1 
ATOM   1085 C CD  . ARG A 1 171 ? 34.832  -20.388 -7.035  1.00 38.63 ?  135 ARG A CD  1 
ATOM   1086 N NE  . ARG A 1 171 ? 33.974  -21.251 -6.244  1.00 48.15 ?  135 ARG A NE  1 
ATOM   1087 C CZ  . ARG A 1 171 ? 32.877  -20.848 -5.617  1.00 49.64 ?  135 ARG A CZ  1 
ATOM   1088 N NH1 . ARG A 1 171 ? 32.447  -19.609 -5.763  1.00 47.97 ?  135 ARG A NH1 1 
ATOM   1089 N NH2 . ARG A 1 171 ? 32.214  -21.686 -4.842  1.00 54.31 ?  135 ARG A NH2 1 
ATOM   1090 N N   . ARG A 1 172 ? 39.047  -19.753 -9.390  1.00 36.32 ?  136 ARG A N   1 
ATOM   1091 C CA  . ARG A 1 172 ? 38.965  -19.312 -10.771 1.00 39.07 ?  136 ARG A CA  1 
ATOM   1092 C C   . ARG A 1 172 ? 39.220  -17.830 -10.835 1.00 37.92 ?  136 ARG A C   1 
ATOM   1093 O O   . ARG A 1 172 ? 38.510  -17.111 -11.509 1.00 36.63 ?  136 ARG A O   1 
ATOM   1094 C CB  . ARG A 1 172 ? 37.639  -19.718 -11.399 1.00 42.69 ?  136 ARG A CB  1 
ATOM   1095 C CG  . ARG A 1 172 ? 37.481  -21.213 -11.587 1.00 40.78 ?  136 ARG A CG  1 
ATOM   1096 C CD  . ARG A 1 172 ? 36.019  -21.615 -11.620 1.00 46.68 ?  136 ARG A CD  1 
ATOM   1097 N N   . ASN A 1 173 ? 40.227  -17.387 -10.094 1.00 37.85 ?  137 ASN A N   1 
ATOM   1098 C CA  . ASN A 1 173 ? 40.630  -15.976 -10.088 1.00 34.63 ?  137 ASN A CA  1 
ATOM   1099 C C   . ASN A 1 173 ? 39.544  -15.039 -9.551  1.00 33.37 ?  137 ASN A C   1 
ATOM   1100 O O   . ASN A 1 173 ? 39.545  -13.843 -9.856  1.00 30.23 ?  137 ASN A O   1 
ATOM   1101 C CB  . ASN A 1 173 ? 41.067  -15.534 -11.485 1.00 36.68 ?  137 ASN A CB  1 
ATOM   1102 C CG  . ASN A 1 173 ? 42.059  -16.495 -12.102 1.00 44.28 ?  137 ASN A CG  1 
ATOM   1103 O OD1 . ASN A 1 173 ? 43.193  -16.622 -11.630 1.00 44.59 ?  137 ASN A OD1 1 
ATOM   1104 N ND2 . ASN A 1 173 ? 41.627  -17.208 -13.138 1.00 45.49 ?  137 ASN A ND2 1 
ATOM   1105 N N   . VAL A 1 174 ? 38.612  -15.553 -8.757  1.00 32.01 ?  138 VAL A N   1 
ATOM   1106 C CA  . VAL A 1 174 ? 37.667  -14.726 -8.011  1.00 34.54 ?  138 VAL A CA  1 
ATOM   1107 C C   . VAL A 1 174 ? 38.132  -14.716 -6.562  1.00 29.25 ?  138 VAL A C   1 
ATOM   1108 O O   . VAL A 1 174 ? 38.255  -15.775 -5.938  1.00 30.05 ?  138 VAL A O   1 
ATOM   1109 C CB  . VAL A 1 174 ? 36.229  -15.251 -8.139  1.00 30.20 ?  138 VAL A CB  1 
ATOM   1110 C CG1 . VAL A 1 174 ? 35.296  -14.486 -7.208  1.00 27.64 ?  138 VAL A CG1 1 
ATOM   1111 C CG2 . VAL A 1 174 ? 35.769  -15.127 -9.576  1.00 31.08 ?  138 VAL A CG2 1 
ATOM   1112 N N   . PHE A 1 175 ? 38.404  -13.529 -6.027  1.00 25.36 ?  139 PHE A N   1 
ATOM   1113 C CA  . PHE A 1 175 ? 39.105  -13.436 -4.756  1.00 25.54 ?  139 PHE A CA  1 
ATOM   1114 C C   . PHE A 1 175 ? 38.128  -13.561 -3.596  1.00 25.32 ?  139 PHE A C   1 
ATOM   1115 O O   . PHE A 1 175 ? 36.902  -13.595 -3.768  1.00 26.43 ?  139 PHE A O   1 
ATOM   1116 C CB  . PHE A 1 175 ? 39.904  -12.136 -4.683  1.00 29.17 ?  139 PHE A CB  1 
ATOM   1117 C CG  . PHE A 1 175 ? 40.817  -11.949 -5.848  1.00 30.26 ?  139 PHE A CG  1 
ATOM   1118 C CD1 . PHE A 1 175 ? 41.857  -12.843 -6.065  1.00 33.99 ?  139 PHE A CD1 1 
ATOM   1119 C CD2 . PHE A 1 175 ? 40.620  -10.923 -6.749  1.00 30.17 ?  139 PHE A CD2 1 
ATOM   1120 C CE1 . PHE A 1 175 ? 42.695  -12.698 -7.141  1.00 36.38 ?  139 PHE A CE1 1 
ATOM   1121 C CE2 . PHE A 1 175 ? 41.460  -10.771 -7.841  1.00 33.30 ?  139 PHE A CE2 1 
ATOM   1122 C CZ  . PHE A 1 175 ? 42.494  -11.662 -8.038  1.00 36.31 ?  139 PHE A CZ  1 
ATOM   1123 N N   . PHE A 1 176 ? 38.688  -13.682 -2.401  1.00 21.47 ?  140 PHE A N   1 
ATOM   1124 C CA  . PHE A 1 176 ? 37.920  -14.019 -1.214  1.00 24.13 ?  140 PHE A CA  1 
ATOM   1125 C C   . PHE A 1 176 ? 37.934  -12.822 -0.284  1.00 26.41 ?  140 PHE A C   1 
ATOM   1126 O O   . PHE A 1 176 ? 39.008  -12.331 0.065   1.00 23.38 ?  140 PHE A O   1 
ATOM   1127 C CB  . PHE A 1 176 ? 38.513  -15.235 -0.478  1.00 25.63 ?  140 PHE A CB  1 
ATOM   1128 C CG  . PHE A 1 176 ? 38.540  -16.514 -1.282  1.00 27.15 ?  140 PHE A CG  1 
ATOM   1129 C CD1 . PHE A 1 176 ? 37.838  -16.643 -2.469  1.00 26.93 ?  140 PHE A CD1 1 
ATOM   1130 C CD2 . PHE A 1 176 ? 39.284  -17.600 -0.831  1.00 27.38 ?  140 PHE A CD2 1 
ATOM   1131 C CE1 . PHE A 1 176 ? 37.885  -17.829 -3.191  1.00 32.05 ?  140 PHE A CE1 1 
ATOM   1132 C CE2 . PHE A 1 176 ? 39.326  -18.781 -1.540  1.00 31.54 ?  140 PHE A CE2 1 
ATOM   1133 C CZ  . PHE A 1 176 ? 38.628  -18.899 -2.724  1.00 31.18 ?  140 PHE A CZ  1 
ATOM   1134 N N   . PHE A 1 177 ? 36.757  -12.368 0.139   1.00 24.82 ?  141 PHE A N   1 
ATOM   1135 C CA  . PHE A 1 177 ? 36.736  -11.354 1.178   1.00 20.71 ?  141 PHE A CA  1 
ATOM   1136 C C   . PHE A 1 177 ? 37.195  -11.969 2.497   1.00 21.51 ?  141 PHE A C   1 
ATOM   1137 O O   . PHE A 1 177 ? 36.949  -13.147 2.777   1.00 23.92 ?  141 PHE A O   1 
ATOM   1138 C CB  . PHE A 1 177 ? 35.339  -10.754 1.317   1.00 23.48 ?  141 PHE A CB  1 
ATOM   1139 C CG  . PHE A 1 177 ? 34.889  -9.947  0.109   1.00 24.90 ?  141 PHE A CG  1 
ATOM   1140 C CD1 . PHE A 1 177 ? 35.644  -8.862  -0.358  1.00 20.55 ?  141 PHE A CD1 1 
ATOM   1141 C CD2 . PHE A 1 177 ? 33.701  -10.261 -0.537  1.00 20.92 ?  141 PHE A CD2 1 
ATOM   1142 C CE1 . PHE A 1 177 ? 35.211  -8.116  -1.456  1.00 21.61 ?  141 PHE A CE1 1 
ATOM   1143 C CE2 . PHE A 1 177 ? 33.262  -9.521  -1.634  1.00 20.45 ?  141 PHE A CE2 1 
ATOM   1144 C CZ  . PHE A 1 177 ? 34.019  -8.441  -2.091  1.00 20.83 ?  141 PHE A CZ  1 
ATOM   1145 N N   . ASP A 1 178 ? 37.877  -11.166 3.312   1.00 23.14 ?  142 ASP A N   1 
ATOM   1146 C CA  . ASP A 1 178 ? 38.332  -11.595 4.640   1.00 24.12 ?  142 ASP A CA  1 
ATOM   1147 C C   . ASP A 1 178 ? 37.459  -10.915 5.688   1.00 24.73 ?  142 ASP A C   1 
ATOM   1148 O O   . ASP A 1 178 ? 37.684  -9.754  6.049   1.00 20.64 ?  142 ASP A O   1 
ATOM   1149 C CB  . ASP A 1 178 ? 39.816  -11.273 4.843   1.00 27.30 ?  142 ASP A CB  1 
ATOM   1150 C CG  . ASP A 1 178 ? 40.337  -11.714 6.205   1.00 24.98 ?  142 ASP A CG  1 
ATOM   1151 O OD1 . ASP A 1 178 ? 39.657  -12.494 6.914   1.00 24.99 ?  142 ASP A OD1 1 
ATOM   1152 O OD2 . ASP A 1 178 ? 41.446  -11.282 6.561   1.00 30.05 ?  142 ASP A OD2 1 
ATOM   1153 N N   . VAL A 1 179 ? 36.461  -11.651 6.188   1.00 25.09 ?  143 VAL A N   1 
ATOM   1154 C CA  . VAL A 1 179 ? 35.540  -11.090 7.174   1.00 24.66 ?  143 VAL A CA  1 
ATOM   1155 C C   . VAL A 1 179 ? 36.247  -10.729 8.468   1.00 25.76 ?  143 VAL A C   1 
ATOM   1156 O O   . VAL A 1 179 ? 35.703  -9.970  9.277   1.00 23.19 ?  143 VAL A O   1 
ATOM   1157 C CB  . VAL A 1 179 ? 34.379  -12.084 7.429   1.00 25.67 ?  143 VAL A CB  1 
ATOM   1158 C CG1 . VAL A 1 179 ? 34.839  -13.270 8.291   1.00 23.84 ?  143 VAL A CG1 1 
ATOM   1159 C CG2 . VAL A 1 179 ? 33.137  -11.370 8.040   1.00 23.37 ?  143 VAL A CG2 1 
ATOM   1160 N N   . LEU A 1 180 ? 37.445  -11.276 8.698   1.00 24.54 ?  144 LEU A N   1 
ATOM   1161 C CA  . LEU A 1 180 ? 38.201  -10.967 9.903   1.00 23.78 ?  144 LEU A CA  1 
ATOM   1162 C C   . LEU A 1 180 ? 38.802  -9.573  9.851   1.00 29.47 ?  144 LEU A C   1 
ATOM   1163 O O   . LEU A 1 180 ? 39.091  -8.990  10.904  1.00 27.67 ?  144 LEU A O   1 
ATOM   1164 C CB  . LEU A 1 180 ? 39.306  -12.000 10.104  1.00 23.84 ?  144 LEU A CB  1 
ATOM   1165 C CG  . LEU A 1 180 ? 38.805  -13.399 10.489  1.00 26.94 ?  144 LEU A CG  1 
ATOM   1166 C CD1 . LEU A 1 180 ? 39.973  -14.330 10.782  1.00 29.96 ?  144 LEU A CD1 1 
ATOM   1167 C CD2 . LEU A 1 180 ? 37.866  -13.324 11.679  1.00 25.39 ?  144 LEU A CD2 1 
ATOM   1168 N N   . ASN A 1 181 ? 38.973  -9.028  8.656   1.00 25.61 ?  145 ASN A N   1 
ATOM   1169 C CA  . ASN A 1 181 ? 39.541  -7.708  8.464   1.00 28.28 ?  145 ASN A CA  1 
ATOM   1170 C C   . ASN A 1 181 ? 38.482  -6.650  8.751   1.00 26.78 ?  145 ASN A C   1 
ATOM   1171 O O   . ASN A 1 181 ? 37.576  -6.454  7.931   1.00 24.74 ?  145 ASN A O   1 
ATOM   1172 C CB  . ASN A 1 181 ? 40.078  -7.581  7.034   1.00 29.11 ?  145 ASN A CB  1 
ATOM   1173 C CG  . ASN A 1 181 ? 40.809  -6.281  6.799   1.00 28.60 ?  145 ASN A CG  1 
ATOM   1174 O OD1 . ASN A 1 181 ? 40.395  -5.242  7.299   1.00 27.25 ?  145 ASN A OD1 1 
ATOM   1175 N ND2 . ASN A 1 181 ? 41.898  -6.324  6.011   1.00 27.11 ?  145 ASN A ND2 1 
ATOM   1176 N N   . PRO A 1 182 ? 38.582  -5.927  9.878   1.00 29.67 ?  146 PRO A N   1 
ATOM   1177 C CA  . PRO A 1 182 ? 37.560  -4.914  10.193  1.00 25.92 ?  146 PRO A CA  1 
ATOM   1178 C C   . PRO A 1 182 ? 37.323  -3.900  9.093   1.00 26.11 ?  146 PRO A C   1 
ATOM   1179 O O   . PRO A 1 182 ? 36.178  -3.488  8.919   1.00 23.79 ?  146 PRO A O   1 
ATOM   1180 C CB  . PRO A 1 182 ? 38.095  -4.237  11.470  1.00 29.42 ?  146 PRO A CB  1 
ATOM   1181 C CG  . PRO A 1 182 ? 39.484  -4.737  11.654  1.00 30.47 ?  146 PRO A CG  1 
ATOM   1182 C CD  . PRO A 1 182 ? 39.596  -6.043  10.941  1.00 25.34 ?  146 PRO A CD  1 
ATOM   1183 N N   . GLU A 1 183 ? 38.345  -3.485  8.333   1.00 26.42 ?  147 GLU A N   1 
ATOM   1184 C CA  . GLU A 1 183 ? 38.103  -2.529  7.248   1.00 29.17 ?  147 GLU A CA  1 
ATOM   1185 C C   . GLU A 1 183 ? 37.274  -3.154  6.130   1.00 26.67 ?  147 GLU A C   1 
ATOM   1186 O O   . GLU A 1 183 ? 36.451  -2.472  5.500   1.00 23.38 ?  147 GLU A O   1 
ATOM   1187 C CB  . GLU A 1 183 ? 39.427  -1.995  6.691   1.00 23.78 ?  147 GLU A CB  1 
ATOM   1188 C CG  . GLU A 1 183 ? 40.463  -1.678  7.759   1.00 30.24 ?  147 GLU A CG  1 
ATOM   1189 C CD  . GLU A 1 183 ? 41.596  -0.829  7.223   1.00 33.28 ?  147 GLU A CD  1 
ATOM   1190 O OE1 . GLU A 1 183 ? 42.032  -1.079  6.077   1.00 33.15 ?  147 GLU A OE1 1 
ATOM   1191 O OE2 . GLU A 1 183 ? 42.026  0.104   7.935   1.00 43.11 ?  147 GLU A OE2 1 
ATOM   1192 N N   . LEU A 1 184 ? 37.484  -4.441  5.855   1.00 23.82 ?  148 LEU A N   1 
ATOM   1193 C CA  . LEU A 1 184 ? 36.616  -5.122  4.903   1.00 23.70 ?  148 LEU A CA  1 
ATOM   1194 C C   . LEU A 1 184 ? 35.168  -5.109  5.383   1.00 24.35 ?  148 LEU A C   1 
ATOM   1195 O O   . LEU A 1 184 ? 34.246  -4.853  4.596   1.00 21.73 ?  148 LEU A O   1 
ATOM   1196 C CB  . LEU A 1 184 ? 37.110  -6.557  4.678   1.00 23.66 ?  148 LEU A CB  1 
ATOM   1197 C CG  . LEU A 1 184 ? 36.260  -7.495  3.809   1.00 22.32 ?  148 LEU A CG  1 
ATOM   1198 C CD1 . LEU A 1 184 ? 35.141  -8.179  4.615   1.00 22.12 ?  148 LEU A CD1 1 
ATOM   1199 C CD2 . LEU A 1 184 ? 35.705  -6.768  2.583   1.00 20.39 ?  148 LEU A CD2 1 
ATOM   1200 N N   . ARG A 1 185 ? 34.946  -5.388  6.671   1.00 21.29 ?  149 ARG A N   1 
ATOM   1201 C CA  . ARG A 1 185 ? 33.583  -5.393  7.193   1.00 23.22 ?  149 ARG A CA  1 
ATOM   1202 C C   . ARG A 1 185 ? 32.927  -4.029  7.010   1.00 27.01 ?  149 ARG A C   1 
ATOM   1203 O O   . ARG A 1 185 ? 31.741  -3.935  6.654   1.00 23.58 ?  149 ARG A O   1 
ATOM   1204 C CB  . ARG A 1 185 ? 33.587  -5.801  8.669   1.00 20.41 ?  149 ARG A CB  1 
ATOM   1205 C CG  . ARG A 1 185 ? 33.997  -7.246  8.909   1.00 22.55 ?  149 ARG A CG  1 
ATOM   1206 C CD  . ARG A 1 185 ? 33.612  -7.748  10.307  1.00 25.81 ?  149 ARG A CD  1 
ATOM   1207 N NE  . ARG A 1 185 ? 34.175  -6.935  11.384  1.00 26.05 ?  149 ARG A NE  1 
ATOM   1208 C CZ  . ARG A 1 185 ? 35.331  -7.178  11.995  1.00 28.95 ?  149 ARG A CZ  1 
ATOM   1209 N NH1 . ARG A 1 185 ? 36.109  -8.193  11.642  1.00 23.14 ?  149 ARG A NH1 1 
ATOM   1210 N NH2 . ARG A 1 185 ? 35.726  -6.372  12.974  1.00 26.27 ?  149 ARG A NH2 1 
ATOM   1211 N N   . GLU A 1 186 ? 33.688  -2.958  7.244   1.00 22.80 ?  150 GLU A N   1 
ATOM   1212 C CA  . GLU A 1 186 ? 33.154  -1.619  7.048   1.00 23.59 ?  150 GLU A CA  1 
ATOM   1213 C C   . GLU A 1 186 ? 32.871  -1.372  5.576   1.00 26.28 ?  150 GLU A C   1 
ATOM   1214 O O   . GLU A 1 186 ? 31.812  -0.844  5.213   1.00 25.53 ?  150 GLU A O   1 
ATOM   1215 C CB  . GLU A 1 186 ? 34.146  -0.583  7.586   1.00 29.97 ?  150 GLU A CB  1 
ATOM   1216 C CG  . GLU A 1 186 ? 33.786  0.899   7.349   1.00 31.77 ?  150 GLU A CG  1 
ATOM   1217 C CD  . GLU A 1 186 ? 32.454  1.340   7.966   1.00 37.16 ?  150 GLU A CD  1 
ATOM   1218 O OE1 . GLU A 1 186 ? 31.907  2.390   7.529   1.00 35.83 ?  150 GLU A OE1 1 
ATOM   1219 O OE2 . GLU A 1 186 ? 31.946  0.624   8.878   1.00 30.49 ?  150 GLU A OE2 1 
ATOM   1220 N N   . TRP A 1 187 ? 33.822  -1.727  4.711   1.00 21.63 ?  151 TRP A N   1 
ATOM   1221 C CA  . TRP A 1 187 ? 33.672  -1.414  3.294   1.00 22.48 ?  151 TRP A CA  1 
ATOM   1222 C C   . TRP A 1 187 ? 32.584  -2.277  2.658   1.00 21.16 ?  151 TRP A C   1 
ATOM   1223 O O   . TRP A 1 187 ? 31.735  -1.777  1.913   1.00 22.85 ?  151 TRP A O   1 
ATOM   1224 C CB  . TRP A 1 187 ? 35.017  -1.593  2.572   1.00 22.52 ?  151 TRP A CB  1 
ATOM   1225 C CG  . TRP A 1 187 ? 34.891  -1.466  1.092   1.00 18.71 ?  151 TRP A CG  1 
ATOM   1226 C CD1 . TRP A 1 187 ? 35.094  -0.347  0.359   1.00 23.34 ?  151 TRP A CD1 1 
ATOM   1227 C CD2 . TRP A 1 187 ? 34.525  -2.497  0.162   1.00 19.54 ?  151 TRP A CD2 1 
ATOM   1228 N NE1 . TRP A 1 187 ? 34.856  -0.601  -0.973  1.00 22.64 ?  151 TRP A NE1 1 
ATOM   1229 C CE2 . TRP A 1 187 ? 34.508  -1.918  -1.117  1.00 22.44 ?  151 TRP A CE2 1 
ATOM   1230 C CE3 . TRP A 1 187 ? 34.205  -3.852  0.291   1.00 21.40 ?  151 TRP A CE3 1 
ATOM   1231 C CZ2 . TRP A 1 187 ? 34.185  -2.642  -2.262  1.00 21.23 ?  151 TRP A CZ2 1 
ATOM   1232 C CZ3 . TRP A 1 187 ? 33.870  -4.573  -0.850  1.00 21.38 ?  151 TRP A CZ3 1 
ATOM   1233 C CH2 . TRP A 1 187 ? 33.865  -3.963  -2.107  1.00 23.10 ?  151 TRP A CH2 1 
ATOM   1234 N N   . TRP A 1 188 ? 32.615  -3.583  2.922   1.00 20.66 ?  152 TRP A N   1 
ATOM   1235 C CA  . TRP A 1 188 ? 31.633  -4.502  2.350   1.00 22.74 ?  152 TRP A CA  1 
ATOM   1236 C C   . TRP A 1 188 ? 30.213  -4.094  2.724   1.00 21.91 ?  152 TRP A C   1 
ATOM   1237 O O   . TRP A 1 188 ? 29.332  -3.990  1.860   1.00 21.42 ?  152 TRP A O   1 
ATOM   1238 C CB  . TRP A 1 188 ? 31.934  -5.928  2.828   1.00 20.68 ?  152 TRP A CB  1 
ATOM   1239 C CG  . TRP A 1 188 ? 31.084  -6.985  2.195   1.00 19.01 ?  152 TRP A CG  1 
ATOM   1240 C CD1 . TRP A 1 188 ? 31.389  -7.735  1.099   1.00 18.31 ?  152 TRP A CD1 1 
ATOM   1241 C CD2 . TRP A 1 188 ? 29.791  -7.418  2.635   1.00 21.73 ?  152 TRP A CD2 1 
ATOM   1242 N NE1 . TRP A 1 188 ? 30.356  -8.602  0.819   1.00 21.29 ?  152 TRP A NE1 1 
ATOM   1243 C CE2 . TRP A 1 188 ? 29.368  -8.432  1.753   1.00 20.96 ?  152 TRP A CE2 1 
ATOM   1244 C CE3 . TRP A 1 188 ? 28.944  -7.039  3.685   1.00 23.41 ?  152 TRP A CE3 1 
ATOM   1245 C CZ2 . TRP A 1 188 ? 28.134  -9.066  1.886   1.00 23.45 ?  152 TRP A CZ2 1 
ATOM   1246 C CZ3 . TRP A 1 188 ? 27.718  -7.665  3.814   1.00 22.77 ?  152 TRP A CZ3 1 
ATOM   1247 C CH2 . TRP A 1 188 ? 27.324  -8.670  2.925   1.00 26.18 ?  152 TRP A CH2 1 
ATOM   1248 N N   . SER A 1 189 ? 29.980  -3.849  4.016   1.00 22.13 ?  153 SER A N   1 
ATOM   1249 C CA  . SER A 1 189 ? 28.644  -3.502  4.492   1.00 25.20 ?  153 SER A CA  1 
ATOM   1250 C C   . SER A 1 189 ? 28.159  -2.184  3.896   1.00 23.62 ?  153 SER A C   1 
ATOM   1251 O O   . SER A 1 189 ? 27.001  -2.080  3.470   1.00 24.33 ?  153 SER A O   1 
ATOM   1252 C CB  . SER A 1 189 ? 28.642  -3.440  6.021   1.00 23.67 ?  153 SER A CB  1 
ATOM   1253 O OG  . SER A 1 189 ? 29.581  -2.484  6.467   1.00 23.32 ?  153 SER A OG  1 
ATOM   1254 N N   . THR A 1 190 ? 29.019  -1.160  3.865   1.00 21.41 ?  154 THR A N   1 
ATOM   1255 C CA  . THR A 1 190 ? 28.661  0.082   3.175   1.00 23.74 ?  154 THR A CA  1 
ATOM   1256 C C   . THR A 1 190 ? 28.362  -0.179  1.701   1.00 24.60 ?  154 THR A C   1 
ATOM   1257 O O   . THR A 1 190 ? 27.423  0.394   1.133   1.00 23.14 ?  154 THR A O   1 
ATOM   1258 C CB  . THR A 1 190 ? 29.787  1.113   3.302   1.00 27.44 ?  154 THR A CB  1 
ATOM   1259 O OG1 . THR A 1 190 ? 29.951  1.506   4.675   1.00 25.16 ?  154 THR A OG1 1 
ATOM   1260 C CG2 . THR A 1 190 ? 29.498  2.342   2.423   1.00 23.84 ?  154 THR A CG2 1 
ATOM   1261 N N   . THR A 1 191 ? 29.152  -1.047  1.067   1.00 23.51 ?  155 THR A N   1 
ATOM   1262 C CA  . THR A 1 191 ? 28.978  -1.325  -0.355  1.00 23.41 ?  155 THR A CA  1 
ATOM   1263 C C   . THR A 1 191 ? 27.634  -1.998  -0.642  1.00 21.95 ?  155 THR A C   1 
ATOM   1264 O O   . THR A 1 191 ? 26.925  -1.601  -1.568  1.00 20.02 ?  155 THR A O   1 
ATOM   1265 C CB  . THR A 1 191 ? 30.129  -2.194  -0.845  1.00 25.85 ?  155 THR A CB  1 
ATOM   1266 O OG1 . THR A 1 191 ? 31.296  -1.381  -0.996  1.00 21.80 ?  155 THR A OG1 1 
ATOM   1267 C CG2 . THR A 1 191 ? 29.777  -2.894  -2.166  1.00 24.58 ?  155 THR A CG2 1 
ATOM   1268 N N   . VAL A 1 192 ? 27.273  -3.029  0.125   1.00 22.55 ?  156 VAL A N   1 
ATOM   1269 C CA  . VAL A 1 192 ? 25.969  -3.663  -0.071  1.00 21.09 ?  156 VAL A CA  1 
ATOM   1270 C C   . VAL A 1 192 ? 24.862  -2.638  0.113   1.00 22.20 ?  156 VAL A C   1 
ATOM   1271 O O   . VAL A 1 192 ? 23.969  -2.507  -0.728  1.00 21.59 ?  156 VAL A O   1 
ATOM   1272 C CB  . VAL A 1 192 ? 25.777  -4.853  0.885   1.00 21.86 ?  156 VAL A CB  1 
ATOM   1273 C CG1 . VAL A 1 192 ? 24.401  -5.491  0.632   1.00 22.66 ?  156 VAL A CG1 1 
ATOM   1274 C CG2 . VAL A 1 192 ? 26.868  -5.889  0.720   1.00 22.26 ?  156 VAL A CG2 1 
ATOM   1275 N N   . ALA A 1 193 ? 24.911  -1.891  1.220   1.00 20.92 ?  157 ALA A N   1 
ATOM   1276 C CA  . ALA A 1 193 ? 23.949  -0.824  1.449   1.00 22.20 ?  157 ALA A CA  1 
ATOM   1277 C C   . ALA A 1 193 ? 23.910  0.147   0.278   1.00 25.10 ?  157 ALA A C   1 
ATOM   1278 O O   . ALA A 1 193 ? 22.833  0.606   -0.122  1.00 23.84 ?  157 ALA A O   1 
ATOM   1279 C CB  . ALA A 1 193 ? 24.292  -0.076  2.742   1.00 22.38 ?  157 ALA A CB  1 
ATOM   1280 N N   . LYS A 1 194 ? 25.075  0.472   -0.289  1.00 23.72 ?  158 LYS A N   1 
ATOM   1281 C CA  . LYS A 1 194 ? 25.079  1.294   -1.493  1.00 24.73 ?  158 LYS A CA  1 
ATOM   1282 C C   . LYS A 1 194 ? 24.391  0.577   -2.643  1.00 22.33 ?  158 LYS A C   1 
ATOM   1283 O O   . LYS A 1 194 ? 23.604  1.181   -3.377  1.00 22.68 ?  158 LYS A O   1 
ATOM   1284 C CB  . LYS A 1 194 ? 26.498  1.677   -1.890  1.00 24.71 ?  158 LYS A CB  1 
ATOM   1285 C CG  . LYS A 1 194 ? 26.520  2.549   -3.133  1.00 25.13 ?  158 LYS A CG  1 
ATOM   1286 C CD  . LYS A 1 194 ? 27.934  2.876   -3.555  1.00 31.41 ?  158 LYS A CD  1 
ATOM   1287 C CE  . LYS A 1 194 ? 27.938  4.049   -4.518  1.00 35.12 ?  158 LYS A CE  1 
ATOM   1288 N NZ  . LYS A 1 194 ? 29.312  4.553   -4.777  1.00 35.24 ?  158 LYS A NZ  1 
ATOM   1289 N N   . GLY A 1 195 ? 24.646  -0.720  -2.802  1.00 20.63 ?  159 GLY A N   1 
ATOM   1290 C CA  . GLY A 1 195 ? 23.983  -1.449  -3.873  1.00 20.05 ?  159 GLY A CA  1 
ATOM   1291 C C   . GLY A 1 195 ? 22.476  -1.498  -3.686  1.00 22.80 ?  159 GLY A C   1 
ATOM   1292 O O   . GLY A 1 195 ? 21.712  -1.397  -4.652  1.00 19.40 ?  159 GLY A O   1 
ATOM   1293 N N   . VAL A 1 196 ? 22.024  -1.650  -2.440  1.00 22.49 ?  160 VAL A N   1 
ATOM   1294 C CA  . VAL A 1 196 ? 20.587  -1.698  -2.194  1.00 22.17 ?  160 VAL A CA  1 
ATOM   1295 C C   . VAL A 1 196 ? 19.954  -0.351  -2.525  1.00 22.93 ?  160 VAL A C   1 
ATOM   1296 O O   . VAL A 1 196 ? 18.868  -0.288  -3.115  1.00 22.59 ?  160 VAL A O   1 
ATOM   1297 C CB  . VAL A 1 196 ? 20.311  -2.114  -0.736  1.00 18.38 ?  160 VAL A CB  1 
ATOM   1298 C CG1 . VAL A 1 196 ? 18.851  -1.835  -0.367  1.00 23.38 ?  160 VAL A CG1 1 
ATOM   1299 C CG2 . VAL A 1 196 ? 20.634  -3.577  -0.517  1.00 17.18 ?  160 VAL A CG2 1 
ATOM   1300 N N   . ALA A 1 197 ? 20.621  0.748   -2.143  1.00 22.80 ?  161 ALA A N   1 
ATOM   1301 C CA  . ALA A 1 197 ? 20.083  2.089   -2.384  1.00 24.92 ?  161 ALA A CA  1 
ATOM   1302 C C   . ALA A 1 197 ? 20.104  2.450   -3.860  1.00 24.44 ?  161 ALA A C   1 
ATOM   1303 O O   . ALA A 1 197 ? 19.147  3.035   -4.370  1.00 25.45 ?  161 ALA A O   1 
ATOM   1304 C CB  . ALA A 1 197 ? 20.879  3.129   -1.591  1.00 25.78 ?  161 ALA A CB  1 
ATOM   1305 N N   . GLU A 1 198 ? 21.190  2.121   -4.559  1.00 24.54 ?  162 GLU A N   1 
ATOM   1306 C CA  . GLU A 1 198 ? 21.297  2.452   -5.977  1.00 24.82 ?  162 GLU A CA  1 
ATOM   1307 C C   . GLU A 1 198 ? 20.328  1.644   -6.821  1.00 26.40 ?  162 GLU A C   1 
ATOM   1308 O O   . GLU A 1 198 ? 19.908  2.097   -7.893  1.00 23.89 ?  162 GLU A O   1 
ATOM   1309 C CB  . GLU A 1 198 ? 22.719  2.202   -6.458  1.00 26.61 ?  162 GLU A CB  1 
ATOM   1310 C CG  . GLU A 1 198 ? 23.702  3.181   -5.921  1.00 29.41 ?  162 GLU A CG  1 
ATOM   1311 C CD  . GLU A 1 198 ? 24.920  3.267   -6.792  1.00 31.26 ?  162 GLU A CD  1 
ATOM   1312 O OE1 . GLU A 1 198 ? 25.380  2.208   -7.268  1.00 27.44 ?  162 GLU A OE1 1 
ATOM   1313 O OE2 . GLU A 1 198 ? 25.408  4.393   -7.001  1.00 35.92 ?  162 GLU A OE2 1 
ATOM   1314 N N   . SER A 1 199 ? 19.974  0.448   -6.373  1.00 23.38 ?  163 SER A N   1 
ATOM   1315 C CA  . SER A 1 199 ? 19.093  -0.418  -7.145  1.00 20.76 ?  163 SER A CA  1 
ATOM   1316 C C   . SER A 1 199 ? 17.617  -0.193  -6.848  1.00 24.63 ?  163 SER A C   1 
ATOM   1317 O O   . SER A 1 199 ? 16.770  -0.682  -7.603  1.00 24.41 ?  163 SER A O   1 
ATOM   1318 C CB  . SER A 1 199 ? 19.445  -1.876  -6.863  1.00 22.85 ?  163 SER A CB  1 
ATOM   1319 O OG  . SER A 1 199 ? 19.272  -2.133  -5.479  1.00 25.44 ?  163 SER A OG  1 
ATOM   1320 N N   . GLY A 1 200 ? 17.284  0.537   -5.785  1.00 24.46 ?  164 GLY A N   1 
ATOM   1321 C CA  . GLY A 1 200 ? 15.900  0.609   -5.352  1.00 22.28 ?  164 GLY A CA  1 
ATOM   1322 C C   . GLY A 1 200 ? 15.348  -0.726  -4.906  1.00 22.09 ?  164 GLY A C   1 
ATOM   1323 O O   . GLY A 1 200 ? 14.140  -0.942  -4.971  1.00 24.90 ?  164 GLY A O   1 
ATOM   1324 N N   . CYS A 1 201 ? 16.205  -1.630  -4.449  1.00 19.78 ?  165 CYS A N   1 
ATOM   1325 C CA  . CYS A 1 201 ? 15.756  -2.898  -3.900  1.00 21.52 ?  165 CYS A CA  1 
ATOM   1326 C C   . CYS A 1 201 ? 15.345  -2.729  -2.442  1.00 24.36 ?  165 CYS A C   1 
ATOM   1327 O O   . CYS A 1 201 ? 15.768  -1.794  -1.757  1.00 21.23 ?  165 CYS A O   1 
ATOM   1328 C CB  . CYS A 1 201 ? 16.853  -3.960  -4.011  1.00 19.87 ?  165 CYS A CB  1 
ATOM   1329 S SG  . CYS A 1 201 ? 17.045  -4.574  -5.671  1.00 21.23 ?  165 CYS A SG  1 
ATOM   1330 N N   . ASP A 1 202 ? 14.523  -3.673  -1.959  1.00 21.04 ?  166 ASP A N   1 
ATOM   1331 C CA  . ASP A 1 202 ? 13.957  -3.605  -0.616  1.00 19.90 ?  166 ASP A CA  1 
ATOM   1332 C C   . ASP A 1 202 ? 14.834  -4.276  0.428   1.00 19.97 ?  166 ASP A C   1 
ATOM   1333 O O   . ASP A 1 202 ? 14.401  -4.472  1.569   1.00 19.75 ?  166 ASP A O   1 
ATOM   1334 C CB  . ASP A 1 202 ? 12.557  -4.217  -0.630  1.00 20.51 ?  166 ASP A CB  1 
ATOM   1335 C CG  . ASP A 1 202 ? 11.700  -3.610  -1.724  1.00 27.21 ?  166 ASP A CG  1 
ATOM   1336 O OD1 . ASP A 1 202 ? 11.259  -2.474  -1.534  1.00 27.83 ?  166 ASP A OD1 1 
ATOM   1337 O OD2 . ASP A 1 202 ? 11.505  -4.234  -2.794  1.00 25.44 ?  166 ASP A OD2 1 
ATOM   1338 N N   . GLY A 1 203 ? 16.053  -4.602  0.074   1.00 20.24 ?  167 GLY A N   1 
ATOM   1339 C CA  . GLY A 1 203 ? 16.956  -5.253  0.986   1.00 21.33 ?  167 GLY A CA  1 
ATOM   1340 C C   . GLY A 1 203 ? 17.943  -6.076  0.195   1.00 19.61 ?  167 GLY A C   1 
ATOM   1341 O O   . GLY A 1 203 ? 18.058  -5.927  -1.022  1.00 19.61 ?  167 GLY A O   1 
ATOM   1342 N N   . ALA A 1 204 ? 18.635  -6.944  0.908   1.00 19.55 ?  168 ALA A N   1 
ATOM   1343 C CA  . ALA A 1 204 ? 19.758  -7.681  0.360   1.00 22.61 ?  168 ALA A CA  1 
ATOM   1344 C C   . ALA A 1 204 ? 19.628  -9.166  0.674   1.00 19.28 ?  168 ALA A C   1 
ATOM   1345 O O   . ALA A 1 204 ? 19.261  -9.552  1.789   1.00 17.87 ?  168 ALA A O   1 
ATOM   1346 C CB  . ALA A 1 204 ? 21.088  -7.141  0.915   1.00 17.91 ?  168 ALA A CB  1 
ATOM   1347 N N   . PHE A 1 205 ? 20.004  -9.952  -0.330  1.00 16.18 ?  169 PHE A N   1 
ATOM   1348 C CA  . PHE A 1 205 ? 20.200  -11.391 -0.121  1.00 20.69 ?  169 PHE A CA  1 
ATOM   1349 C C   . PHE A 1 205 ? 21.720  -11.528 0.033   1.00 21.17 ?  169 PHE A C   1 
ATOM   1350 O O   . PHE A 1 205 ? 22.452  -11.299 -0.932  1.00 21.01 ?  169 PHE A O   1 
ATOM   1351 C CB  . PHE A 1 205 ? 19.657  -12.217 -1.286  1.00 21.76 ?  169 PHE A CB  1 
ATOM   1352 C CG  . PHE A 1 205 ? 20.006  -13.683 -1.279  1.00 20.44 ?  169 PHE A CG  1 
ATOM   1353 C CD1 . PHE A 1 205 ? 21.292  -14.115 -1.554  1.00 20.17 ?  169 PHE A CD1 1 
ATOM   1354 C CD2 . PHE A 1 205 ? 19.036  -14.637 -1.027  1.00 24.21 ?  169 PHE A CD2 1 
ATOM   1355 C CE1 . PHE A 1 205 ? 21.603  -15.464 -1.554  1.00 21.37 ?  169 PHE A CE1 1 
ATOM   1356 C CE2 . PHE A 1 205 ? 19.347  -15.986 -1.034  1.00 24.59 ?  169 PHE A CE2 1 
ATOM   1357 C CZ  . PHE A 1 205 ? 20.630  -16.397 -1.295  1.00 23.77 ?  169 PHE A CZ  1 
ATOM   1358 N N   . ILE A 1 206 ? 22.168  -11.875 1.227   1.00 19.07 ?  170 ILE A N   1 
ATOM   1359 C CA  . ILE A 1 206 ? 23.594  -12.059 1.489   1.00 22.60 ?  170 ILE A CA  1 
ATOM   1360 C C   . ILE A 1 206 ? 23.927  -13.537 1.362   1.00 23.35 ?  170 ILE A C   1 
ATOM   1361 O O   . ILE A 1 206 ? 23.434  -14.366 2.141   1.00 21.27 ?  170 ILE A O   1 
ATOM   1362 C CB  . ILE A 1 206 ? 23.998  -11.537 2.875   1.00 22.24 ?  170 ILE A CB  1 
ATOM   1363 C CG1 . ILE A 1 206 ? 23.774  -10.017 2.981   1.00 21.98 ?  170 ILE A CG1 1 
ATOM   1364 C CG2 . ILE A 1 206 ? 25.437  -11.928 3.167   1.00 20.24 ?  170 ILE A CG2 1 
ATOM   1365 C CD1 . ILE A 1 206 ? 23.987  -9.251  1.666   1.00 21.07 ?  170 ILE A CD1 1 
ATOM   1366 N N   . ASP A 1 207 ? 24.801  -13.836 0.409   1.00 21.61 ?  171 ASP A N   1 
ATOM   1367 C CA  . ASP A 1 207 ? 25.202  -15.238 0.159   1.00 23.40 ?  171 ASP A CA  1 
ATOM   1368 C C   . ASP A 1 207 ? 26.494  -15.590 0.898   1.00 25.48 ?  171 ASP A C   1 
ATOM   1369 O O   . ASP A 1 207 ? 27.394  -14.749 0.932   1.00 22.46 ?  171 ASP A O   1 
ATOM   1370 C CB  . ASP A 1 207 ? 25.334  -15.507 -1.337  1.00 24.80 ?  171 ASP A CB  1 
ATOM   1371 C CG  . ASP A 1 207 ? 25.390  -16.971 -1.725  1.00 32.00 ?  171 ASP A CG  1 
ATOM   1372 O OD1 . ASP A 1 207 ? 25.205  -17.826 -0.842  1.00 29.32 ?  171 ASP A OD1 1 
ATOM   1373 O OD2 . ASP A 1 207 ? 25.612  -17.233 -2.915  1.00 32.28 ?  171 ASP A OD2 1 
ATOM   1374 N N   . GLN A 1 208 ? 26.554  -16.786 1.455   1.00 25.39 ?  172 GLN A N   1 
ATOM   1375 C CA  . GLN A 1 208 ? 27.728  -17.298 2.159   1.00 29.46 ?  172 GLN A CA  1 
ATOM   1376 C C   . GLN A 1 208 ? 27.861  -16.776 3.579   1.00 26.59 ?  172 GLN A C   1 
ATOM   1377 O O   . GLN A 1 208 ? 27.895  -15.603 3.829   1.00 30.37 ?  172 GLN A O   1 
ATOM   1378 C CB  . GLN A 1 208 ? 29.015  -17.121 1.342   1.00 26.86 ?  172 GLN A CB  1 
ATOM   1379 C CG  . GLN A 1 208 ? 28.910  -17.625 -0.087  1.00 26.08 ?  172 GLN A CG  1 
ATOM   1380 C CD  . GLN A 1 208 ? 28.661  -19.116 -0.173  1.00 32.95 ?  172 GLN A CD  1 
ATOM   1381 O OE1 . GLN A 1 208 ? 29.576  -19.914 -0.039  1.00 32.65 ?  172 GLN A OE1 1 
ATOM   1382 N NE2 . GLN A 1 208 ? 27.420  -19.492 -0.410  1.00 32.72 ?  172 GLN A NE2 1 
ATOM   1383 N N   . MET A 1 209 ? 27.896  -17.703 4.508   1.00 30.90 ?  173 MET A N   1 
ATOM   1384 C CA  . MET A 1 209 ? 28.056  -17.322 5.899   1.00 32.37 ?  173 MET A CA  1 
ATOM   1385 C C   . MET A 1 209 ? 29.353  -17.823 6.495   1.00 32.63 ?  173 MET A C   1 
ATOM   1386 O O   . MET A 1 209 ? 29.645  -17.520 7.657   1.00 33.42 ?  173 MET A O   1 
ATOM   1387 C CB  . MET A 1 209 ? 26.887  -17.859 6.732   1.00 29.56 ?  173 MET A CB  1 
ATOM   1388 C CG  . MET A 1 209 ? 25.531  -17.434 6.209   1.00 32.34 ?  173 MET A CG  1 
ATOM   1389 S SD  . MET A 1 209 ? 25.134  -15.806 6.864   1.00 41.03 ?  173 MET A SD  1 
ATOM   1390 C CE  . MET A 1 209 ? 24.793  -14.805 5.390   1.00 27.21 ?  173 MET A CE  1 
ATOM   1391 N N   . HIS A 1 210 ? 30.134  -18.577 5.733   1.00 31.58 ?  174 HIS A N   1 
ATOM   1392 C CA  . HIS A 1 210 ? 31.203  -19.376 6.302   1.00 28.56 ?  174 HIS A CA  1 
ATOM   1393 C C   . HIS A 1 210 ? 32.472  -18.580 6.537   1.00 29.67 ?  174 HIS A C   1 
ATOM   1394 O O   . HIS A 1 210 ? 33.334  -19.036 7.299   1.00 31.55 ?  174 HIS A O   1 
ATOM   1395 C CB  . HIS A 1 210 ? 31.493  -20.556 5.376   1.00 29.37 ?  174 HIS A CB  1 
ATOM   1396 C CG  . HIS A 1 210 ? 31.659  -20.162 3.943   1.00 31.07 ?  174 HIS A CG  1 
ATOM   1397 N ND1 . HIS A 1 210 ? 32.714  -19.390 3.506   1.00 27.09 ?  174 HIS A ND1 1 
ATOM   1398 C CD2 . HIS A 1 210 ? 30.907  -20.428 2.845   1.00 27.59 ?  174 HIS A CD2 1 
ATOM   1399 C CE1 . HIS A 1 210 ? 32.615  -19.206 2.200   1.00 29.73 ?  174 HIS A CE1 1 
ATOM   1400 N NE2 . HIS A 1 210 ? 31.527  -19.825 1.774   1.00 31.81 ?  174 HIS A NE2 1 
ATOM   1401 N N   . GLY A 1 211 ? 32.604  -17.415 5.905   1.00 30.01 ?  175 GLY A N   1 
ATOM   1402 C CA  . GLY A 1 211 ? 33.827  -16.637 5.988   1.00 30.22 ?  175 GLY A CA  1 
ATOM   1403 C C   . GLY A 1 211 ? 35.093  -17.463 5.825   1.00 28.40 ?  175 GLY A C   1 
ATOM   1404 O O   . GLY A 1 211 ? 36.114  -17.163 6.448   1.00 29.88 ?  175 GLY A O   1 
ATOM   1405 N N   . PHE A 1 212 ? 35.035  -18.511 5.001   1.00 30.60 ?  176 PHE A N   1 
ATOM   1406 C CA  . PHE A 1 212 ? 36.182  -19.394 4.762   1.00 28.75 ?  176 PHE A CA  1 
ATOM   1407 C C   . PHE A 1 212 ? 36.819  -19.855 6.071   1.00 32.86 ?  176 PHE A C   1 
ATOM   1408 O O   . PHE A 1 212 ? 38.043  -19.853 6.220   1.00 29.79 ?  176 PHE A O   1 
ATOM   1409 C CB  . PHE A 1 212 ? 37.223  -18.707 3.877   1.00 25.92 ?  176 PHE A CB  1 
ATOM   1410 C CG  . PHE A 1 212 ? 36.655  -18.118 2.624   1.00 29.11 ?  176 PHE A CG  1 
ATOM   1411 C CD1 . PHE A 1 212 ? 36.435  -18.914 1.507   1.00 28.17 ?  176 PHE A CD1 1 
ATOM   1412 C CD2 . PHE A 1 212 ? 36.342  -16.759 2.559   1.00 27.25 ?  176 PHE A CD2 1 
ATOM   1413 C CE1 . PHE A 1 212 ? 35.930  -18.370 0.339   1.00 26.51 ?  176 PHE A CE1 1 
ATOM   1414 C CE2 . PHE A 1 212 ? 35.830  -16.206 1.395   1.00 26.60 ?  176 PHE A CE2 1 
ATOM   1415 C CZ  . PHE A 1 212 ? 35.618  -17.019 0.281   1.00 29.35 ?  176 PHE A CZ  1 
ATOM   1416 N N   . ALA A 1 213 ? 35.978  -20.233 7.042   1.00 33.01 ?  177 ALA A N   1 
ATOM   1417 C CA  . ALA A 1 213 ? 36.501  -20.644 8.344   1.00 33.16 ?  177 ALA A CA  1 
ATOM   1418 C C   . ALA A 1 213 ? 37.494  -21.796 8.215   1.00 37.34 ?  177 ALA A C   1 
ATOM   1419 O O   . ALA A 1 213 ? 38.473  -21.864 8.977   1.00 36.01 ?  177 ALA A O   1 
ATOM   1420 C CB  . ALA A 1 213 ? 35.353  -21.025 9.273   1.00 29.19 ?  177 ALA A CB  1 
ATOM   1421 N N   . TRP A 1 214 ? 37.289  -22.680 7.232   1.00 36.60 ?  178 TRP A N   1 
ATOM   1422 C CA  . TRP A 1 214 ? 38.186  -23.813 7.041   1.00 38.23 ?  178 TRP A CA  1 
ATOM   1423 C C   . TRP A 1 214 ? 39.569  -23.396 6.549   1.00 38.20 ?  178 TRP A C   1 
ATOM   1424 O O   . TRP A 1 214 ? 40.506  -24.205 6.615   1.00 33.10 ?  178 TRP A O   1 
ATOM   1425 C CB  . TRP A 1 214 ? 37.564  -24.808 6.068   1.00 32.14 ?  178 TRP A CB  1 
ATOM   1426 C CG  . TRP A 1 214 ? 37.274  -24.231 4.731   1.00 34.76 ?  178 TRP A CG  1 
ATOM   1427 C CD1 . TRP A 1 214 ? 38.114  -24.191 3.653   1.00 37.73 ?  178 TRP A CD1 1 
ATOM   1428 C CD2 . TRP A 1 214 ? 36.049  -23.627 4.309   1.00 34.56 ?  178 TRP A CD2 1 
ATOM   1429 N NE1 . TRP A 1 214 ? 37.483  -23.594 2.585   1.00 37.68 ?  178 TRP A NE1 1 
ATOM   1430 C CE2 . TRP A 1 214 ? 36.216  -23.238 2.963   1.00 34.18 ?  178 TRP A CE2 1 
ATOM   1431 C CE3 . TRP A 1 214 ? 34.821  -23.385 4.937   1.00 32.67 ?  178 TRP A CE3 1 
ATOM   1432 C CZ2 . TRP A 1 214 ? 35.208  -22.619 2.235   1.00 30.17 ?  178 TRP A CZ2 1 
ATOM   1433 C CZ3 . TRP A 1 214 ? 33.824  -22.769 4.214   1.00 33.13 ?  178 TRP A CZ3 1 
ATOM   1434 C CH2 . TRP A 1 214 ? 34.021  -22.394 2.875   1.00 32.62 ?  178 TRP A CH2 1 
ATOM   1435 N N   . LEU A 1 215 ? 39.725  -22.167 6.059   1.00 33.43 ?  179 LEU A N   1 
ATOM   1436 C CA  . LEU A 1 215 ? 41.050  -21.656 5.733   1.00 33.50 ?  179 LEU A CA  1 
ATOM   1437 C C   . LEU A 1 215 ? 41.761  -21.041 6.933   1.00 33.98 ?  179 LEU A C   1 
ATOM   1438 O O   . LEU A 1 215 ? 42.913  -20.622 6.811   1.00 35.90 ?  179 LEU A O   1 
ATOM   1439 C CB  . LEU A 1 215 ? 40.967  -20.608 4.619   1.00 37.74 ?  179 LEU A CB  1 
ATOM   1440 C CG  . LEU A 1 215 ? 40.455  -21.036 3.245   1.00 38.10 ?  179 LEU A CG  1 
ATOM   1441 C CD1 . LEU A 1 215 ? 40.496  -19.842 2.309   1.00 32.83 ?  179 LEU A CD1 1 
ATOM   1442 C CD2 . LEU A 1 215 ? 41.251  -22.206 2.680   1.00 38.67 ?  179 LEU A CD2 1 
ATOM   1443 N N   . ARG A 1 216 ? 41.101  -20.943 8.073   1.00 35.71 ?  180 ARG A N   1 
ATOM   1444 C CA  . ARG A 1 216 ? 41.710  -20.402 9.274   1.00 39.73 ?  180 ARG A CA  1 
ATOM   1445 C C   . ARG A 1 216 ? 40.976  -21.065 10.432  1.00 39.67 ?  180 ARG A C   1 
ATOM   1446 O O   . ARG A 1 216 ? 40.305  -20.416 11.239  1.00 39.19 ?  180 ARG A O   1 
ATOM   1447 C CB  . ARG A 1 216 ? 41.627  -18.876 9.319   1.00 35.40 ?  180 ARG A CB  1 
ATOM   1448 C CG  . ARG A 1 216 ? 40.259  -18.300 8.961   1.00 32.64 ?  180 ARG A CG  1 
ATOM   1449 C CD  . ARG A 1 216 ? 40.215  -17.888 7.492   1.00 31.01 ?  180 ARG A CD  1 
ATOM   1450 N NE  . ARG A 1 216 ? 39.088  -17.010 7.216   1.00 27.96 ?  180 ARG A NE  1 
ATOM   1451 C CZ  . ARG A 1 216 ? 39.130  -15.690 7.298   1.00 28.06 ?  180 ARG A CZ  1 
ATOM   1452 N NH1 . ARG A 1 216 ? 40.246  -15.051 7.610   1.00 25.85 ?  180 ARG A NH1 1 
ATOM   1453 N NH2 . ARG A 1 216 ? 38.027  -14.991 7.049   1.00 27.63 ?  180 ARG A NH2 1 
ATOM   1454 N N   . ALA A 1 217 ? 41.095  -22.395 10.485  1.00 35.19 ?  181 ALA A N   1 
ATOM   1455 C CA  . ALA A 1 217 ? 40.226  -23.187 11.350  1.00 38.40 ?  181 ALA A CA  1 
ATOM   1456 C C   . ALA A 1 217 ? 40.404  -22.806 12.810  1.00 41.10 ?  181 ALA A C   1 
ATOM   1457 O O   . ALA A 1 217 ? 39.448  -22.889 13.597  1.00 39.48 ?  181 ALA A O   1 
ATOM   1458 C CB  . ALA A 1 217 ? 40.497  -24.678 11.145  1.00 36.96 ?  181 ALA A CB  1 
ATOM   1459 N N   . ASP A 1 218 ? 41.613  -22.367 13.174  1.00 37.13 ?  182 ASP A N   1 
ATOM   1460 C CA  . ASP A 1 218 ? 41.887  -21.923 14.533  1.00 40.00 ?  182 ASP A CA  1 
ATOM   1461 C C   . ASP A 1 218 ? 41.095  -20.675 14.886  1.00 42.47 ?  182 ASP A C   1 
ATOM   1462 O O   . ASP A 1 218 ? 40.828  -20.422 16.066  1.00 48.47 ?  182 ASP A O   1 
ATOM   1463 C CB  . ASP A 1 218 ? 43.381  -21.653 14.694  1.00 41.75 ?  182 ASP A CB  1 
ATOM   1464 C CG  . ASP A 1 218 ? 43.880  -20.570 13.759  1.00 49.85 ?  182 ASP A CG  1 
ATOM   1465 O OD1 . ASP A 1 218 ? 43.551  -20.626 12.549  1.00 51.16 ?  182 ASP A OD1 1 
ATOM   1466 O OD2 . ASP A 1 218 ? 44.604  -19.661 14.230  1.00 50.88 ?  182 ASP A OD2 1 
ATOM   1467 N N   . LYS A 1 219 ? 40.716  -19.884 13.886  1.00 39.89 ?  183 LYS A N   1 
ATOM   1468 C CA  . LYS A 1 219 ? 39.978  -18.652 14.100  1.00 38.96 ?  183 LYS A CA  1 
ATOM   1469 C C   . LYS A 1 219 ? 38.487  -18.804 13.828  1.00 39.48 ?  183 LYS A C   1 
ATOM   1470 O O   . LYS A 1 219 ? 37.782  -17.793 13.758  1.00 41.07 ?  183 LYS A O   1 
ATOM   1471 C CB  . LYS A 1 219 ? 40.557  -17.542 13.224  1.00 41.58 ?  183 LYS A CB  1 
ATOM   1472 C CG  . LYS A 1 219 ? 41.970  -17.105 13.603  1.00 44.56 ?  183 LYS A CG  1 
ATOM   1473 C CD  . LYS A 1 219 ? 42.499  -16.047 12.643  1.00 47.71 ?  183 LYS A CD  1 
ATOM   1474 C CE  . LYS A 1 219 ? 44.017  -16.064 12.542  1.00 51.34 ?  183 LYS A CE  1 
ATOM   1475 N NZ  . LYS A 1 219 ? 44.559  -17.442 12.315  1.00 55.76 ?  183 LYS A NZ  1 
ATOM   1476 N N   . SER A 1 220 ? 37.987  -20.040 13.703  1.00 37.47 ?  184 SER A N   1 
ATOM   1477 C CA  . SER A 1 220 ? 36.615  -20.256 13.239  1.00 38.44 ?  184 SER A CA  1 
ATOM   1478 C C   . SER A 1 220 ? 35.604  -19.489 14.089  1.00 34.49 ?  184 SER A C   1 
ATOM   1479 O O   . SER A 1 220 ? 34.755  -18.761 13.561  1.00 33.24 ?  184 SER A O   1 
ATOM   1480 C CB  . SER A 1 220 ? 36.290  -21.755 13.232  1.00 37.98 ?  184 SER A CB  1 
ATOM   1481 O OG  . SER A 1 220 ? 36.943  -22.425 14.290  1.00 44.25 ?  184 SER A OG  1 
ATOM   1482 N N   . GLU A 1 221 ? 35.691  -19.626 15.415  1.00 34.91 ?  185 GLU A N   1 
ATOM   1483 C CA  . GLU A 1 221 ? 34.799  -18.876 16.295  1.00 37.90 ?  185 GLU A CA  1 
ATOM   1484 C C   . GLU A 1 221 ? 34.865  -17.370 16.019  1.00 37.53 ?  185 GLU A C   1 
ATOM   1485 O O   . GLU A 1 221 ? 33.829  -16.698 15.972  1.00 39.90 ?  185 GLU A O   1 
ATOM   1486 C CB  . GLU A 1 221 ? 35.148  -19.179 17.755  1.00 41.65 ?  185 GLU A CB  1 
ATOM   1487 N N   . ASP A 1 222 ? 36.073  -16.819 15.838  1.00 36.68 ?  186 ASP A N   1 
ATOM   1488 C CA  . ASP A 1 222 ? 36.205  -15.397 15.509  1.00 34.62 ?  186 ASP A CA  1 
ATOM   1489 C C   . ASP A 1 222 ? 35.519  -15.069 14.183  1.00 32.89 ?  186 ASP A C   1 
ATOM   1490 O O   . ASP A 1 222 ? 34.923  -13.996 14.023  1.00 33.20 ?  186 ASP A O   1 
ATOM   1491 C CB  . ASP A 1 222 ? 37.682  -15.011 15.413  1.00 37.90 ?  186 ASP A CB  1 
ATOM   1492 C CG  . ASP A 1 222 ? 38.390  -15.014 16.751  1.00 43.70 ?  186 ASP A CG  1 
ATOM   1493 O OD1 . ASP A 1 222 ? 37.808  -14.547 17.750  1.00 47.08 ?  186 ASP A OD1 1 
ATOM   1494 O OD2 . ASP A 1 222 ? 39.540  -15.490 16.792  1.00 44.02 ?  186 ASP A OD2 1 
ATOM   1495 N N   . VAL A 1 223 ? 35.644  -15.963 13.202  1.00 31.53 ?  187 VAL A N   1 
ATOM   1496 C CA  . VAL A 1 223 ? 34.998  -15.757 11.907  1.00 34.68 ?  187 VAL A CA  1 
ATOM   1497 C C   . VAL A 1 223 ? 33.487  -15.672 12.087  1.00 34.09 ?  187 VAL A C   1 
ATOM   1498 O O   . VAL A 1 223 ? 32.826  -14.761 11.572  1.00 30.68 ?  187 VAL A O   1 
ATOM   1499 C CB  . VAL A 1 223 ? 35.404  -16.882 10.933  1.00 35.89 ?  187 VAL A CB  1 
ATOM   1500 C CG1 . VAL A 1 223 ? 34.669  -16.749 9.602   1.00 32.63 ?  187 VAL A CG1 1 
ATOM   1501 C CG2 . VAL A 1 223 ? 36.930  -16.873 10.724  1.00 28.58 ?  187 VAL A CG2 1 
ATOM   1502 N N   . GLN A 1 224 ? 32.926  -16.608 12.857  1.00 33.75 ?  188 GLN A N   1 
ATOM   1503 C CA  . GLN A 1 224 ? 31.500  -16.592 13.144  1.00 31.95 ?  188 GLN A CA  1 
ATOM   1504 C C   . GLN A 1 224 ? 31.074  -15.273 13.775  1.00 31.63 ?  188 GLN A C   1 
ATOM   1505 O O   . GLN A 1 224 ? 30.064  -14.686 13.368  1.00 34.73 ?  188 GLN A O   1 
ATOM   1506 C CB  . GLN A 1 224 ? 31.152  -17.793 14.029  1.00 32.10 ?  188 GLN A CB  1 
ATOM   1507 C CG  . GLN A 1 224 ? 31.399  -19.131 13.295  1.00 34.73 ?  188 GLN A CG  1 
ATOM   1508 C CD  . GLN A 1 224 ? 31.028  -20.374 14.098  1.00 38.43 ?  188 GLN A CD  1 
ATOM   1509 O OE1 . GLN A 1 224 ? 30.327  -20.292 15.109  1.00 44.78 ?  188 GLN A OE1 1 
ATOM   1510 N NE2 . GLN A 1 224 ? 31.488  -21.536 13.637  1.00 34.67 ?  188 GLN A NE2 1 
ATOM   1511 N N   . LYS A 1 225 ? 31.845  -14.775 14.750  1.00 31.09 ?  189 LYS A N   1 
ATOM   1512 C CA  . LYS A 1 225 ? 31.529  -13.495 15.387  1.00 29.64 ?  189 LYS A CA  1 
ATOM   1513 C C   . LYS A 1 225 ? 31.713  -12.323 14.422  1.00 32.99 ?  189 LYS A C   1 
ATOM   1514 O O   . LYS A 1 225 ? 30.941  -11.352 14.450  1.00 30.87 ?  189 LYS A O   1 
ATOM   1515 C CB  . LYS A 1 225 ? 32.409  -13.301 16.632  1.00 35.66 ?  189 LYS A CB  1 
ATOM   1516 C CG  . LYS A 1 225 ? 32.664  -11.827 17.023  1.00 39.29 ?  189 LYS A CG  1 
ATOM   1517 C CD  . LYS A 1 225 ? 34.134  -11.568 17.446  1.00 46.81 ?  189 LYS A CD  1 
ATOM   1518 C CE  . LYS A 1 225 ? 35.139  -11.538 16.261  1.00 43.45 ?  189 LYS A CE  1 
ATOM   1519 N NZ  . LYS A 1 225 ? 35.242  -10.187 15.590  1.00 44.34 ?  189 LYS A NZ  1 
ATOM   1520 N N   . ALA A 1 226 ? 32.746  -12.385 13.580  1.00 28.02 ?  190 ALA A N   1 
ATOM   1521 C CA  . ALA A 1 226 ? 32.953  -11.330 12.600  1.00 30.05 ?  190 ALA A CA  1 
ATOM   1522 C C   . ALA A 1 226 ? 31.808  -11.283 11.594  1.00 25.72 ?  190 ALA A C   1 
ATOM   1523 O O   . ALA A 1 226 ? 31.358  -10.198 11.213  1.00 25.15 ?  190 ALA A O   1 
ATOM   1524 C CB  . ALA A 1 226 ? 34.299  -11.525 11.891  1.00 27.40 ?  190 ALA A CB  1 
ATOM   1525 N N   . MET A 1 227 ? 31.340  -12.446 11.129  1.00 28.38 ?  191 MET A N   1 
ATOM   1526 C CA  . MET A 1 227 ? 30.169  -12.468 10.251  1.00 30.30 ?  191 MET A CA  1 
ATOM   1527 C C   . MET A 1 227 ? 29.016  -11.694 10.880  1.00 28.38 ?  191 MET A C   1 
ATOM   1528 O O   . MET A 1 227 ? 28.383  -10.852 10.234  1.00 24.74 ?  191 MET A O   1 
ATOM   1529 C CB  . MET A 1 227 ? 29.738  -13.912 9.963   1.00 28.84 ?  191 MET A CB  1 
ATOM   1530 C CG  . MET A 1 227 ? 29.913  -14.409 8.521   1.00 36.71 ?  191 MET A CG  1 
ATOM   1531 S SD  . MET A 1 227 ? 29.497  -13.259 7.183   1.00 29.98 ?  191 MET A SD  1 
ATOM   1532 C CE  . MET A 1 227 ? 27.763  -13.579 6.923   1.00 32.90 ?  191 MET A CE  1 
ATOM   1533 N N   . GLY A 1 228 ? 28.749  -11.949 12.165  1.00 28.74 ?  192 GLY A N   1 
ATOM   1534 C CA  . GLY A 1 228 ? 27.648  -11.266 12.821  1.00 25.88 ?  192 GLY A CA  1 
ATOM   1535 C C   . GLY A 1 228 ? 27.829  -9.765  12.820  1.00 27.22 ?  192 GLY A C   1 
ATOM   1536 O O   . GLY A 1 228 ? 26.878  -9.012  12.583  1.00 27.68 ?  192 GLY A O   1 
ATOM   1537 N N   . GLU A 1 229 ? 29.065  -9.311  13.059  1.00 28.66 ?  193 GLU A N   1 
ATOM   1538 C CA  . GLU A 1 229 ? 29.343  -7.884  13.091  1.00 27.34 ?  193 GLU A CA  1 
ATOM   1539 C C   . GLU A 1 229 ? 29.128  -7.257  11.723  1.00 24.10 ?  193 GLU A C   1 
ATOM   1540 O O   . GLU A 1 229 ? 28.569  -6.159  11.617  1.00 26.13 ?  193 GLU A O   1 
ATOM   1541 C CB  . GLU A 1 229 ? 30.780  -7.641  13.581  1.00 30.78 ?  193 GLU A CB  1 
ATOM   1542 C CG  . GLU A 1 229 ? 30.980  -8.000  15.051  1.00 35.23 ?  193 GLU A CG  1 
ATOM   1543 C CD  . GLU A 1 229 ? 32.433  -7.931  15.519  1.00 42.99 ?  193 GLU A CD  1 
ATOM   1544 O OE1 . GLU A 1 229 ? 33.351  -8.237  14.722  1.00 43.53 ?  193 GLU A OE1 1 
ATOM   1545 O OE2 . GLU A 1 229 ? 32.655  -7.601  16.703  1.00 46.12 ?  193 GLU A OE2 1 
ATOM   1546 N N   . MET A 1 230 ? 29.564  -7.941  10.667  1.00 24.32 ?  194 MET A N   1 
ATOM   1547 C CA  . MET A 1 230 ? 29.411  -7.378  9.333   1.00 22.69 ?  194 MET A CA  1 
ATOM   1548 C C   . MET A 1 230 ? 27.935  -7.269  8.966   1.00 26.13 ?  194 MET A C   1 
ATOM   1549 O O   . MET A 1 230 ? 27.503  -6.272  8.372   1.00 22.38 ?  194 MET A O   1 
ATOM   1550 C CB  . MET A 1 230 ? 30.163  -8.230  8.316   1.00 23.90 ?  194 MET A CB  1 
ATOM   1551 C CG  . MET A 1 230 ? 30.184  -7.622  6.936   1.00 21.43 ?  194 MET A CG  1 
ATOM   1552 S SD  . MET A 1 230 ? 31.477  -8.284  5.913   1.00 23.36 ?  194 MET A SD  1 
ATOM   1553 C CE  . MET A 1 230 ? 30.813  -9.918  5.560   1.00 23.85 ?  194 MET A CE  1 
ATOM   1554 N N   . MET A 1 231 ? 27.142  -8.274  9.344   1.00 26.59 ?  195 MET A N   1 
ATOM   1555 C CA  . MET A 1 231 ? 25.703  -8.207  9.111   1.00 27.32 ?  195 MET A CA  1 
ATOM   1556 C C   . MET A 1 231 ? 25.065  -7.112  9.950   1.00 24.94 ?  195 MET A C   1 
ATOM   1557 O O   . MET A 1 231 ? 24.189  -6.385  9.468   1.00 31.65 ?  195 MET A O   1 
ATOM   1558 C CB  . MET A 1 231 ? 25.068  -9.554  9.417   1.00 24.71 ?  195 MET A CB  1 
ATOM   1559 C CG  . MET A 1 231 ? 25.565  -10.673 8.532   1.00 24.06 ?  195 MET A CG  1 
ATOM   1560 S SD  . MET A 1 231 ? 25.326  -10.306 6.785   1.00 29.84 ?  195 MET A SD  1 
ATOM   1561 C CE  . MET A 1 231 ? 27.044  -9.973  6.281   1.00 23.03 ?  195 MET A CE  1 
ATOM   1562 N N   . ALA A 1 232 ? 25.500  -6.962  11.204  1.00 27.04 ?  196 ALA A N   1 
ATOM   1563 C CA  . ALA A 1 232 ? 24.933  -5.909  12.042  1.00 29.00 ?  196 ALA A CA  1 
ATOM   1564 C C   . ALA A 1 232 ? 25.229  -4.536  11.460  1.00 29.55 ?  196 ALA A C   1 
ATOM   1565 O O   . ALA A 1 232 ? 24.389  -3.630  11.528  1.00 30.56 ?  196 ALA A O   1 
ATOM   1566 C CB  . ALA A 1 232 ? 25.474  -6.012  13.468  1.00 33.22 ?  196 ALA A CB  1 
ATOM   1567 N N   . LEU A 1 233 ? 26.434  -4.355  10.906  1.00 26.31 ?  197 LEU A N   1 
ATOM   1568 C CA  . LEU A 1 233 ? 26.757  -3.110  10.202  1.00 26.51 ?  197 LEU A CA  1 
ATOM   1569 C C   . LEU A 1 233 ? 25.822  -2.890  9.020   1.00 26.17 ?  197 LEU A C   1 
ATOM   1570 O O   . LEU A 1 233 ? 25.195  -1.832  8.894   1.00 25.27 ?  197 LEU A O   1 
ATOM   1571 C CB  . LEU A 1 233 ? 28.206  -3.134  9.717   1.00 22.98 ?  197 LEU A CB  1 
ATOM   1572 C CG  . LEU A 1 233 ? 29.321  -3.060  10.768  1.00 30.32 ?  197 LEU A CG  1 
ATOM   1573 C CD1 . LEU A 1 233 ? 30.698  -3.382  10.161  1.00 22.07 ?  197 LEU A CD1 1 
ATOM   1574 C CD2 . LEU A 1 233 ? 29.337  -1.689  11.440  1.00 23.29 ?  197 LEU A CD2 1 
ATOM   1575 N N   . LEU A 1 234 ? 25.729  -3.882  8.131   1.00 28.24 ?  198 LEU A N   1 
ATOM   1576 C CA  . LEU A 1 234 ? 24.886  -3.746  6.945   1.00 26.93 ?  198 LEU A CA  1 
ATOM   1577 C C   . LEU A 1 234 ? 23.441  -3.435  7.330   1.00 27.85 ?  198 LEU A C   1 
ATOM   1578 O O   . LEU A 1 234 ? 22.803  -2.548  6.747   1.00 24.16 ?  198 LEU A O   1 
ATOM   1579 C CB  . LEU A 1 234 ? 24.955  -5.026  6.111   1.00 26.66 ?  198 LEU A CB  1 
ATOM   1580 C CG  . LEU A 1 234 ? 23.941  -5.056  4.954   1.00 26.62 ?  198 LEU A CG  1 
ATOM   1581 C CD1 . LEU A 1 234 ? 24.241  -3.914  3.975   1.00 23.86 ?  198 LEU A CD1 1 
ATOM   1582 C CD2 . LEU A 1 234 ? 23.915  -6.413  4.255   1.00 21.21 ?  198 LEU A CD2 1 
ATOM   1583 N N   . LYS A 1 235 ? 22.916  -4.158  8.322   1.00 28.52 ?  199 LYS A N   1 
ATOM   1584 C CA  . LYS A 1 235 ? 21.541  -3.959  8.757   1.00 29.44 ?  199 LYS A CA  1 
ATOM   1585 C C   . LYS A 1 235 ? 21.311  -2.515  9.182   1.00 31.59 ?  199 LYS A C   1 
ATOM   1586 O O   . LYS A 1 235 ? 20.308  -1.901  8.800   1.00 33.98 ?  199 LYS A O   1 
ATOM   1587 C CB  . LYS A 1 235 ? 21.212  -4.951  9.884   1.00 29.95 ?  199 LYS A CB  1 
ATOM   1588 C CG  . LYS A 1 235 ? 19.732  -5.007  10.317  1.00 33.01 ?  199 LYS A CG  1 
ATOM   1589 C CD  . LYS A 1 235 ? 18.800  -5.396  9.167   1.00 29.56 ?  199 LYS A CD  1 
ATOM   1590 C CE  . LYS A 1 235 ? 17.378  -5.615  9.661   1.00 31.97 ?  199 LYS A CE  1 
ATOM   1591 N NZ  . LYS A 1 235 ? 16.334  -5.306  8.624   1.00 26.31 ?  199 LYS A NZ  1 
ATOM   1592 N N   . ARG A 1 236 ? 22.255  -1.938  9.934   1.00 32.83 ?  200 ARG A N   1 
ATOM   1593 C CA  . ARG A 1 236 ? 22.154  -0.527  10.308  1.00 30.99 ?  200 ARG A CA  1 
ATOM   1594 C C   . ARG A 1 236 ? 22.359  0.393   9.105   1.00 31.05 ?  200 ARG A C   1 
ATOM   1595 O O   . ARG A 1 236 ? 21.630  1.374   8.923   1.00 29.62 ?  200 ARG A O   1 
ATOM   1596 C CB  . ARG A 1 236 ? 23.181  -0.188  11.391  1.00 34.95 ?  200 ARG A CB  1 
ATOM   1597 C CG  . ARG A 1 236 ? 23.412  1.319   11.510  1.00 36.17 ?  200 ARG A CG  1 
ATOM   1598 C CD  . ARG A 1 236 ? 24.339  1.685   12.646  1.00 41.89 ?  200 ARG A CD  1 
ATOM   1599 N NE  . ARG A 1 236 ? 25.718  1.283   12.388  1.00 45.23 ?  200 ARG A NE  1 
ATOM   1600 C CZ  . ARG A 1 236 ? 26.566  1.921   11.588  1.00 40.92 ?  200 ARG A CZ  1 
ATOM   1601 N NH1 . ARG A 1 236 ? 26.200  3.001   10.908  1.00 35.91 ?  200 ARG A NH1 1 
ATOM   1602 N NH2 . ARG A 1 236 ? 27.812  1.462   11.466  1.00 33.93 ?  200 ARG A NH2 1 
ATOM   1603 N N   . LYS A 1 237 ? 23.377  0.126   8.291   1.00 28.74 ?  201 LYS A N   1 
ATOM   1604 C CA  . LYS A 1 237 ? 23.666  1.048   7.202   1.00 26.30 ?  201 LYS A CA  1 
ATOM   1605 C C   . LYS A 1 237 ? 22.545  1.083   6.170   1.00 26.72 ?  201 LYS A C   1 
ATOM   1606 O O   . LYS A 1 237 ? 22.392  2.081   5.463   1.00 31.41 ?  201 LYS A O   1 
ATOM   1607 C CB  . LYS A 1 237 ? 24.987  0.669   6.547   1.00 27.71 ?  201 LYS A CB  1 
ATOM   1608 C CG  . LYS A 1 237 ? 26.177  0.986   7.432   1.00 27.96 ?  201 LYS A CG  1 
ATOM   1609 C CD  . LYS A 1 237 ? 27.358  0.097   7.089   1.00 27.44 ?  201 LYS A CD  1 
ATOM   1610 C CE  . LYS A 1 237 ? 28.611  0.544   7.832   1.00 27.84 ?  201 LYS A CE  1 
ATOM   1611 N NZ  . LYS A 1 237 ? 29.275  1.598   7.066   1.00 34.08 ?  201 LYS A NZ  1 
ATOM   1612 N N   . MET A 1 238 ? 21.758  0.010   6.062   1.00 25.11 ?  202 MET A N   1 
ATOM   1613 C CA  . MET A 1 238 ? 20.697  -0.028  5.061   1.00 27.61 ?  202 MET A CA  1 
ATOM   1614 C C   . MET A 1 238 ? 19.559  0.924   5.396   1.00 31.56 ?  202 MET A C   1 
ATOM   1615 O O   . MET A 1 238 ? 18.852  1.386   4.487   1.00 29.84 ?  202 MET A O   1 
ATOM   1616 C CB  . MET A 1 238 ? 20.180  -1.461  4.915   1.00 25.61 ?  202 MET A CB  1 
ATOM   1617 C CG  . MET A 1 238 ? 20.785  -2.197  3.735   1.00 23.26 ?  202 MET A CG  1 
ATOM   1618 S SD  . MET A 1 238 ? 20.057  -3.812  3.385   1.00 25.51 ?  202 MET A SD  1 
ATOM   1619 C CE  . MET A 1 238 ? 19.622  -4.487  5.000   1.00 19.80 ?  202 MET A CE  1 
ATOM   1620 N N   . GLY A 1 239 ? 19.385  1.259   6.666   1.00 31.00 ?  203 GLY A N   1 
ATOM   1621 C CA  . GLY A 1 239 ? 18.276  2.092   7.061   1.00 27.82 ?  203 GLY A CA  1 
ATOM   1622 C C   . GLY A 1 239 ? 17.070  1.246   7.400   1.00 27.20 ?  203 GLY A C   1 
ATOM   1623 O O   . GLY A 1 239 ? 17.115  0.012   7.355   1.00 26.70 ?  203 GLY A O   1 
ATOM   1624 N N   . PRO A 1 240 ? 15.950  1.906   7.711   1.00 33.21 ?  204 PRO A N   1 
ATOM   1625 C CA  . PRO A 1 240 ? 14.931  1.279   8.571   1.00 34.55 ?  204 PRO A CA  1 
ATOM   1626 C C   . PRO A 1 240 ? 13.942  0.306   7.935   1.00 36.53 ?  204 PRO A C   1 
ATOM   1627 O O   . PRO A 1 240 ? 13.226  -0.372  8.693   1.00 46.60 ?  204 PRO A O   1 
ATOM   1628 C CB  . PRO A 1 240 ? 14.171  2.482   9.161   1.00 37.87 ?  204 PRO A CB  1 
ATOM   1629 C CG  . PRO A 1 240 ? 14.845  3.692   8.697   1.00 36.76 ?  204 PRO A CG  1 
ATOM   1630 C CD  . PRO A 1 240 ? 15.907  3.375   7.727   1.00 30.34 ?  204 PRO A CD  1 
ATOM   1631 N N   . ASP A 1 241 ? 13.805  0.195   6.627   1.00 31.72 ?  205 ASP A N   1 
ATOM   1632 C CA  . ASP A 1 241 ? 12.731  -0.711  6.213   1.00 27.49 ?  205 ASP A CA  1 
ATOM   1633 C C   . ASP A 1 241 ? 13.225  -1.737  5.212   1.00 28.57 ?  205 ASP A C   1 
ATOM   1634 O O   . ASP A 1 241 ? 12.527  -2.062  4.241   1.00 27.28 ?  205 ASP A O   1 
ATOM   1635 C CB  . ASP A 1 241 ? 11.545  0.063   5.647   1.00 30.92 ?  205 ASP A CB  1 
ATOM   1636 C CG  . ASP A 1 241 ? 10.729  0.749   6.737   1.00 38.19 ?  205 ASP A CG  1 
ATOM   1637 O OD1 . ASP A 1 241 ? 10.227  0.054   7.660   1.00 35.33 ?  205 ASP A OD1 1 
ATOM   1638 O OD2 . ASP A 1 241 ? 10.594  1.989   6.668   1.00 40.59 ?  205 ASP A OD2 1 
ATOM   1639 N N   . LYS A 1 242 ? 14.409  -2.298  5.475   1.00 26.82 ?  206 LYS A N   1 
ATOM   1640 C CA  . LYS A 1 242 ? 15.157  -3.106  4.521   1.00 23.29 ?  206 LYS A CA  1 
ATOM   1641 C C   . LYS A 1 242 ? 15.281  -4.537  5.020   1.00 21.89 ?  206 LYS A C   1 
ATOM   1642 O O   . LYS A 1 242 ? 15.622  -4.770  6.185   1.00 20.97 ?  206 LYS A O   1 
ATOM   1643 C CB  . LYS A 1 242 ? 16.533  -2.493  4.280   1.00 23.73 ?  206 LYS A CB  1 
ATOM   1644 C CG  . LYS A 1 242 ? 16.437  -1.106  3.709   1.00 22.97 ?  206 LYS A CG  1 
ATOM   1645 C CD  . LYS A 1 242 ? 15.907  -1.160  2.281   1.00 25.84 ?  206 LYS A CD  1 
ATOM   1646 C CE  . LYS A 1 242 ? 15.497  0.240   1.811   1.00 28.25 ?  206 LYS A CE  1 
ATOM   1647 N NZ  . LYS A 1 242 ? 15.292  0.384   0.342   1.00 35.16 ?  206 LYS A NZ  1 
ATOM   1648 N N   . ILE A 1 243 ? 15.010  -5.490  4.135   1.00 20.75 ?  207 ILE A N   1 
ATOM   1649 C CA  . ILE A 1 243 ? 15.033  -6.904  4.484   1.00 20.87 ?  207 ILE A CA  1 
ATOM   1650 C C   . ILE A 1 243 ? 16.458  -7.418  4.361   1.00 18.46 ?  207 ILE A C   1 
ATOM   1651 O O   . ILE A 1 243 ? 17.133  -7.203  3.350   1.00 17.21 ?  207 ILE A O   1 
ATOM   1652 C CB  . ILE A 1 243 ? 14.081  -7.708  3.583   1.00 24.63 ?  207 ILE A CB  1 
ATOM   1653 C CG1 . ILE A 1 243 ? 12.632  -7.270  3.784   1.00 18.94 ?  207 ILE A CG1 1 
ATOM   1654 C CG2 . ILE A 1 243 ? 14.265  -9.222  3.769   1.00 18.44 ?  207 ILE A CG2 1 
ATOM   1655 C CD1 . ILE A 1 243 ? 11.731  -7.729  2.648   1.00 22.49 ?  207 ILE A CD1 1 
ATOM   1656 N N   . LEU A 1 244 ? 16.902  -8.117  5.370   1.00 19.92 ?  208 LEU A N   1 
ATOM   1657 C CA  . LEU A 1 244 ? 18.174  -8.814  5.327   1.00 23.87 ?  208 LEU A CA  1 
ATOM   1658 C C   . LEU A 1 244 ? 17.909  -10.320 5.297   1.00 22.25 ?  208 LEU A C   1 
ATOM   1659 O O   . LEU A 1 244 ? 17.437  -10.896 6.281   1.00 21.66 ?  208 LEU A O   1 
ATOM   1660 C CB  . LEU A 1 244 ? 19.018  -8.401  6.524   1.00 23.00 ?  208 LEU A CB  1 
ATOM   1661 C CG  . LEU A 1 244 ? 20.510  -8.691  6.483   1.00 27.65 ?  208 LEU A CG  1 
ATOM   1662 C CD1 . LEU A 1 244 ? 21.073  -8.588  5.055   1.00 26.90 ?  208 LEU A CD1 1 
ATOM   1663 C CD2 . LEU A 1 244 ? 21.231  -7.727  7.450   1.00 25.32 ?  208 LEU A CD2 1 
ATOM   1664 N N   . LEU A 1 245 ? 18.206  -10.948 4.163   1.00 20.20 ?  209 LEU A N   1 
ATOM   1665 C CA  . LEU A 1 245 ? 18.106  -12.388 3.988   1.00 21.62 ?  209 LEU A CA  1 
ATOM   1666 C C   . LEU A 1 245 ? 19.513  -12.973 3.932   1.00 24.94 ?  209 LEU A C   1 
ATOM   1667 O O   . LEU A 1 245 ? 20.319  -12.575 3.081   1.00 24.69 ?  209 LEU A O   1 
ATOM   1668 C CB  . LEU A 1 245 ? 17.335  -12.727 2.707   1.00 22.48 ?  209 LEU A CB  1 
ATOM   1669 C CG  . LEU A 1 245 ? 16.703  -14.119 2.578   1.00 25.88 ?  209 LEU A CG  1 
ATOM   1670 C CD1 . LEU A 1 245 ? 15.774  -14.155 1.378   1.00 28.35 ?  209 LEU A CD1 1 
ATOM   1671 C CD2 . LEU A 1 245 ? 17.735  -15.235 2.470   1.00 24.94 ?  209 LEU A CD2 1 
ATOM   1672 N N   . GLY A 1 246 ? 19.796  -13.935 4.806   1.00 22.72 ?  210 GLY A N   1 
ATOM   1673 C CA  . GLY A 1 246 ? 21.080  -14.628 4.814   1.00 24.71 ?  210 GLY A CA  1 
ATOM   1674 C C   . GLY A 1 246 ? 20.943  -16.040 4.277   1.00 25.70 ?  210 GLY A C   1 
ATOM   1675 O O   . GLY A 1 246 ? 20.079  -16.798 4.716   1.00 23.83 ?  210 GLY A O   1 
ATOM   1676 N N   . ASN A 1 247 ? 21.808  -16.377 3.333   1.00 20.49 ?  211 ASN A N   1 
ATOM   1677 C CA  . ASN A 1 247 ? 21.748  -17.726 2.727   1.00 25.27 ?  211 ASN A CA  1 
ATOM   1678 C C   . ASN A 1 247 ? 22.249  -18.774 3.712   1.00 26.49 ?  211 ASN A C   1 
ATOM   1679 O O   . ASN A 1 247 ? 23.282  -18.555 4.342   1.00 25.16 ?  211 ASN A O   1 
ATOM   1680 C CB  . ASN A 1 247 ? 22.500  -17.863 1.406   1.00 27.43 ?  211 ASN A CB  1 
ATOM   1681 C CG  . ASN A 1 247 ? 22.134  -19.115 0.636   1.00 28.57 ?  211 ASN A CG  1 
ATOM   1682 O OD1 . ASN A 1 247 ? 21.136  -19.764 0.932   1.00 28.00 ?  211 ASN A OD1 1 
ATOM   1683 N ND2 . ASN A 1 247 ? 22.935  -19.462 -0.356  1.00 23.94 ?  211 ASN A ND2 1 
ATOM   1684 N N   . ASN A 1 248 ? 21.468  -19.839 3.853   1.00 29.47 ?  212 ASN A N   1 
ATOM   1685 C CA  . ASN A 1 248 ? 21.861  -20.956 4.712   1.00 27.30 ?  212 ASN A CA  1 
ATOM   1686 C C   . ASN A 1 248 ? 22.108  -20.502 6.140   1.00 27.19 ?  212 ASN A C   1 
ATOM   1687 O O   . ASN A 1 248 ? 22.983  -21.026 6.834   1.00 30.12 ?  212 ASN A O   1 
ATOM   1688 C CB  . ASN A 1 248 ? 23.075  -21.670 4.134   1.00 30.30 ?  212 ASN A CB  1 
ATOM   1689 C CG  . ASN A 1 248 ? 22.743  -22.360 2.845   1.00 31.85 ?  212 ASN A CG  1 
ATOM   1690 O OD1 . ASN A 1 248 ? 21.756  -23.087 2.782   1.00 30.04 ?  212 ASN A OD1 1 
ATOM   1691 N ND2 . ASN A 1 248 ? 23.536  -22.135 1.809   1.00 31.18 ?  212 ASN A ND2 1 
ATOM   1692 N N   . ALA A 1 249 ? 21.334  -19.514 6.584   1.00 24.99 ?  213 ALA A N   1 
ATOM   1693 C CA  . ALA A 1 249 ? 21.572  -18.901 7.887   1.00 30.98 ?  213 ALA A CA  1 
ATOM   1694 C C   . ALA A 1 249 ? 20.949  -19.674 9.039   1.00 35.01 ?  213 ALA A C   1 
ATOM   1695 O O   . ALA A 1 249 ? 21.049  -19.226 10.191  1.00 31.26 ?  213 ALA A O   1 
ATOM   1696 C CB  . ALA A 1 249 ? 21.061  -17.473 7.911   1.00 29.97 ?  213 ALA A CB  1 
ATOM   1697 N N   . ASN A 1 250 ? 20.337  -20.824 8.758   1.00 31.59 ?  214 ASN A N   1 
ATOM   1698 C CA  . ASN A 1 250 ? 19.964  -21.759 9.805   1.00 26.78 ?  214 ASN A CA  1 
ATOM   1699 C C   . ASN A 1 250 ? 21.180  -22.440 10.403  1.00 33.90 ?  214 ASN A C   1 
ATOM   1700 O O   . ASN A 1 250 ? 21.092  -22.984 11.512  1.00 33.23 ?  214 ASN A O   1 
ATOM   1701 C CB  . ASN A 1 250 ? 19.043  -22.819 9.223   1.00 27.93 ?  214 ASN A CB  1 
ATOM   1702 C CG  . ASN A 1 250 ? 19.680  -23.514 8.038   1.00 28.97 ?  214 ASN A CG  1 
ATOM   1703 O OD1 . ASN A 1 250 ? 19.804  -22.931 6.959   1.00 28.60 ?  214 ASN A OD1 1 
ATOM   1704 N ND2 . ASN A 1 250 ? 20.136  -24.742 8.245   1.00 30.40 ?  214 ASN A ND2 1 
ATOM   1705 N N   . GLN A 1 251 ? 22.305  -22.444 9.687   1.00 28.25 ?  215 GLN A N   1 
ATOM   1706 C CA  . GLN A 1 251 ? 23.428  -23.249 10.132  1.00 31.79 ?  215 GLN A CA  1 
ATOM   1707 C C   . GLN A 1 251 ? 24.062  -22.625 11.369  1.00 30.26 ?  215 GLN A C   1 
ATOM   1708 O O   . GLN A 1 251 ? 24.005  -21.410 11.587  1.00 33.41 ?  215 GLN A O   1 
ATOM   1709 C CB  . GLN A 1 251 ? 24.450  -23.422 9.006   1.00 30.29 ?  215 GLN A CB  1 
ATOM   1710 C CG  . GLN A 1 251 ? 23.824  -23.928 7.702   1.00 30.43 ?  215 GLN A CG  1 
ATOM   1711 C CD  . GLN A 1 251 ? 24.856  -24.451 6.718   1.00 37.10 ?  215 GLN A CD  1 
ATOM   1712 O OE1 . GLN A 1 251 ? 26.027  -24.036 6.729   1.00 29.20 ?  215 GLN A OE1 1 
ATOM   1713 N NE2 . GLN A 1 251 ? 24.434  -25.387 5.874   1.00 32.45 ?  215 GLN A NE2 1 
ATOM   1714 N N   . ASP A 1 252 ? 24.638  -23.488 12.205  1.00 34.22 ?  216 ASP A N   1 
ATOM   1715 C CA  . ASP A 1 252 ? 25.280  -23.024 13.427  1.00 32.77 ?  216 ASP A CA  1 
ATOM   1716 C C   . ASP A 1 252 ? 26.368  -22.006 13.127  1.00 35.22 ?  216 ASP A C   1 
ATOM   1717 O O   . ASP A 1 252 ? 26.631  -21.129 13.954  1.00 35.53 ?  216 ASP A O   1 
ATOM   1718 C CB  . ASP A 1 252 ? 25.866  -24.211 14.204  1.00 36.02 ?  216 ASP A CB  1 
ATOM   1719 N N   . ILE A 1 253 ? 27.007  -22.090 11.953  1.00 33.10 ?  217 ILE A N   1 
ATOM   1720 C CA  . ILE A 1 253 ? 28.103  -21.169 11.663  1.00 35.26 ?  217 ILE A CA  1 
ATOM   1721 C C   . ILE A 1 253 ? 27.613  -19.743 11.474  1.00 33.94 ?  217 ILE A C   1 
ATOM   1722 O O   . ILE A 1 253 ? 28.421  -18.803 11.496  1.00 33.29 ?  217 ILE A O   1 
ATOM   1723 C CB  . ILE A 1 253 ? 28.896  -21.626 10.423  1.00 38.73 ?  217 ILE A CB  1 
ATOM   1724 C CG1 . ILE A 1 253 ? 27.962  -21.766 9.210   1.00 35.23 ?  217 ILE A CG1 1 
ATOM   1725 C CG2 . ILE A 1 253 ? 29.642  -22.937 10.722  1.00 33.93 ?  217 ILE A CG2 1 
ATOM   1726 C CD1 . ILE A 1 253 ? 28.659  -21.560 7.874   1.00 36.17 ?  217 ILE A CD1 1 
ATOM   1727 N N   . ALA A 1 254 ? 26.305  -19.560 11.311  1.00 33.62 ?  218 ALA A N   1 
ATOM   1728 C CA  . ALA A 1 254 ? 25.706  -18.242 11.155  1.00 33.61 ?  218 ALA A CA  1 
ATOM   1729 C C   . ALA A 1 254 ? 25.010  -17.760 12.422  1.00 32.11 ?  218 ALA A C   1 
ATOM   1730 O O   . ALA A 1 254 ? 24.264  -16.778 12.362  1.00 34.30 ?  218 ALA A O   1 
ATOM   1731 C CB  . ALA A 1 254 ? 24.712  -18.247 9.989   1.00 34.49 ?  218 ALA A CB  1 
ATOM   1732 N N   . LYS A 1 255 ? 25.239  -18.416 13.568  1.00 33.23 ?  219 LYS A N   1 
ATOM   1733 C CA  . LYS A 1 255 ? 24.480  -18.081 14.774  1.00 37.13 ?  219 LYS A CA  1 
ATOM   1734 C C   . LYS A 1 255 ? 24.708  -16.631 15.205  1.00 34.89 ?  219 LYS A C   1 
ATOM   1735 O O   . LYS A 1 255 ? 23.774  -15.958 15.654  1.00 31.73 ?  219 LYS A O   1 
ATOM   1736 C CB  . LYS A 1 255 ? 24.799  -19.071 15.901  1.00 38.62 ?  219 LYS A CB  1 
ATOM   1737 C CG  . LYS A 1 255 ? 26.178  -18.981 16.546  1.00 42.61 ?  219 LYS A CG  1 
ATOM   1738 C CD  . LYS A 1 255 ? 26.696  -20.393 16.857  1.00 47.78 ?  219 LYS A CD  1 
ATOM   1739 C CE  . LYS A 1 255 ? 27.732  -20.411 17.977  1.00 52.45 ?  219 LYS A CE  1 
ATOM   1740 N NZ  . LYS A 1 255 ? 27.157  -20.128 19.324  1.00 54.54 ?  219 LYS A NZ  1 
ATOM   1741 N N   . ASP A 1 256 ? 25.923  -16.110 15.025  1.00 37.49 ?  220 ASP A N   1 
ATOM   1742 C CA  . ASP A 1 256 ? 26.131  -14.688 15.308  1.00 34.40 ?  220 ASP A CA  1 
ATOM   1743 C C   . ASP A 1 256 ? 25.492  -13.801 14.240  1.00 34.27 ?  220 ASP A C   1 
ATOM   1744 O O   . ASP A 1 256 ? 25.074  -12.673 14.541  1.00 32.95 ?  220 ASP A O   1 
ATOM   1745 C CB  . ASP A 1 256 ? 27.620  -14.384 15.436  1.00 33.55 ?  220 ASP A CB  1 
ATOM   1746 C CG  . ASP A 1 256 ? 28.289  -15.212 16.502  1.00 42.20 ?  220 ASP A CG  1 
ATOM   1747 O OD1 . ASP A 1 256 ? 27.804  -15.167 17.657  1.00 44.27 ?  220 ASP A OD1 1 
ATOM   1748 O OD2 . ASP A 1 256 ? 29.281  -15.915 16.188  1.00 39.79 ?  220 ASP A OD2 1 
ATOM   1749 N N   . ALA A 1 257 ? 25.413  -14.287 12.992  1.00 33.23 ?  221 ALA A N   1 
ATOM   1750 C CA  . ALA A 1 257 ? 24.741  -13.532 11.930  1.00 31.05 ?  221 ALA A CA  1 
ATOM   1751 C C   . ALA A 1 257 ? 23.227  -13.565 12.098  1.00 35.70 ?  221 ALA A C   1 
ATOM   1752 O O   . ALA A 1 257 ? 22.551  -12.547 11.899  1.00 35.28 ?  221 ALA A O   1 
ATOM   1753 C CB  . ALA A 1 257 ? 25.132  -14.092 10.561  1.00 29.87 ?  221 ALA A CB  1 
ATOM   1754 N N   . PHE A 1 258 ? 22.689  -14.719 12.495  1.00 31.24 ?  222 PHE A N   1 
ATOM   1755 C CA  . PHE A 1 258 ? 21.245  -14.949 12.537  1.00 34.49 ?  222 PHE A CA  1 
ATOM   1756 C C   . PHE A 1 258 ? 20.431  -13.836 13.206  1.00 34.25 ?  222 PHE A C   1 
ATOM   1757 O O   . PHE A 1 258 ? 19.416  -13.421 12.624  1.00 33.24 ?  222 PHE A O   1 
ATOM   1758 C CB  . PHE A 1 258 ? 21.009  -16.308 13.214  1.00 36.56 ?  222 PHE A CB  1 
ATOM   1759 C CG  . PHE A 1 258 ? 19.566  -16.737 13.238  1.00 40.06 ?  222 PHE A CG  1 
ATOM   1760 C CD1 . PHE A 1 258 ? 18.948  -17.216 12.092  1.00 38.11 ?  222 PHE A CD1 1 
ATOM   1761 C CD2 . PHE A 1 258 ? 18.828  -16.658 14.412  1.00 39.75 ?  222 PHE A CD2 1 
ATOM   1762 C CE1 . PHE A 1 258 ? 17.616  -17.611 12.116  1.00 34.17 ?  222 PHE A CE1 1 
ATOM   1763 C CE2 . PHE A 1 258 ? 17.499  -17.050 14.441  1.00 38.00 ?  222 PHE A CE2 1 
ATOM   1764 C CZ  . PHE A 1 258 ? 16.894  -17.528 13.290  1.00 36.23 ?  222 PHE A CZ  1 
ATOM   1765 N N   . PRO A 1 259 ? 20.785  -13.322 14.396  1.00 31.49 ?  223 PRO A N   1 
ATOM   1766 C CA  . PRO A 1 259 ? 19.873  -12.382 15.081  1.00 35.78 ?  223 PRO A CA  1 
ATOM   1767 C C   . PRO A 1 259 ? 19.511  -11.133 14.297  1.00 29.69 ?  223 PRO A C   1 
ATOM   1768 O O   . PRO A 1 259 ? 18.378  -10.649 14.422  1.00 27.83 ?  223 PRO A O   1 
ATOM   1769 C CB  . PRO A 1 259 ? 20.646  -12.025 16.358  1.00 31.79 ?  223 PRO A CB  1 
ATOM   1770 C CG  . PRO A 1 259 ? 21.475  -13.196 16.603  1.00 32.30 ?  223 PRO A CG  1 
ATOM   1771 C CD  . PRO A 1 259 ? 21.929  -13.657 15.262  1.00 33.22 ?  223 PRO A CD  1 
ATOM   1772 N N   . VAL A 1 260 ? 20.431  -10.574 13.509  1.00 27.13 ?  224 VAL A N   1 
ATOM   1773 C CA  . VAL A 1 260 ? 20.100  -9.338  12.795  1.00 31.37 ?  224 VAL A CA  1 
ATOM   1774 C C   . VAL A 1 260 ? 19.381  -9.607  11.484  1.00 26.72 ?  224 VAL A C   1 
ATOM   1775 O O   . VAL A 1 260 ? 18.881  -8.670  10.853  1.00 26.96 ?  224 VAL A O   1 
ATOM   1776 C CB  . VAL A 1 260 ? 21.365  -8.504  12.531  1.00 27.06 ?  224 VAL A CB  1 
ATOM   1777 C CG1 . VAL A 1 260 ? 22.150  -8.330  13.826  1.00 27.94 ?  224 VAL A CG1 1 
ATOM   1778 C CG2 . VAL A 1 260 ? 22.226  -9.170  11.492  1.00 27.37 ?  224 VAL A CG2 1 
ATOM   1779 N N   . MET A 1 261 ? 19.301  -10.866 11.073  1.00 27.27 ?  225 MET A N   1 
ATOM   1780 C CA  . MET A 1 261 ? 18.672  -11.247 9.811   1.00 30.21 ?  225 MET A CA  1 
ATOM   1781 C C   . MET A 1 261 ? 17.156  -11.171 9.928   1.00 25.17 ?  225 MET A C   1 
ATOM   1782 O O   . MET A 1 261 ? 16.584  -11.532 10.959  1.00 29.50 ?  225 MET A O   1 
ATOM   1783 C CB  . MET A 1 261 ? 19.043  -12.673 9.473   1.00 29.21 ?  225 MET A CB  1 
ATOM   1784 C CG  . MET A 1 261 ? 20.497  -12.948 9.658   1.00 39.52 ?  225 MET A CG  1 
ATOM   1785 S SD  . MET A 1 261 ? 21.507  -12.730 8.213   1.00 51.04 ?  225 MET A SD  1 
ATOM   1786 C CE  . MET A 1 261 ? 21.979  -11.030 8.276   1.00 33.91 ?  225 MET A CE  1 
ATOM   1787 N N   . ASP A 1 262 ? 16.503  -10.742 8.855   1.00 24.27 ?  226 ASP A N   1 
ATOM   1788 C CA  . ASP A 1 262 ? 15.054  -10.859 8.766   1.00 27.46 ?  226 ASP A CA  1 
ATOM   1789 C C   . ASP A 1 262 ? 14.611  -12.189 8.192   1.00 23.14 ?  226 ASP A C   1 
ATOM   1790 O O   . ASP A 1 262 ? 13.451  -12.569 8.374   1.00 24.45 ?  226 ASP A O   1 
ATOM   1791 C CB  . ASP A 1 262 ? 14.496  -9.724  7.911   1.00 21.83 ?  226 ASP A CB  1 
ATOM   1792 C CG  . ASP A 1 262 ? 14.921  -8.389  8.430   1.00 25.97 ?  226 ASP A CG  1 
ATOM   1793 O OD1 . ASP A 1 262 ? 14.505  -8.063  9.554   1.00 27.71 ?  226 ASP A OD1 1 
ATOM   1794 O OD2 . ASP A 1 262 ? 15.705  -7.689  7.750   1.00 26.72 ?  226 ASP A OD2 1 
ATOM   1795 N N   . ALA A 1 263 ? 15.507  -12.904 7.519   1.00 24.80 ?  227 ALA A N   1 
ATOM   1796 C CA  . ALA A 1 263 ? 15.127  -14.092 6.771   1.00 21.30 ?  227 ALA A CA  1 
ATOM   1797 C C   . ALA A 1 263 ? 16.349  -14.978 6.623   1.00 25.05 ?  227 ALA A C   1 
ATOM   1798 O O   . ALA A 1 263 ? 17.488  -14.502 6.673   1.00 21.57 ?  227 ALA A O   1 
ATOM   1799 C CB  . ALA A 1 263 ? 14.561  -13.720 5.399   1.00 19.25 ?  227 ALA A CB  1 
ATOM   1800 N N   . SER A 1 264 ? 16.098  -16.280 6.437   1.00 25.71 ?  228 SER A N   1 
ATOM   1801 C CA  . SER A 1 264 ? 17.164  -17.235 6.164   1.00 23.65 ?  228 SER A CA  1 
ATOM   1802 C C   . SER A 1 264 ? 16.693  -18.229 5.110   1.00 27.69 ?  228 SER A C   1 
ATOM   1803 O O   . SER A 1 264 ? 15.515  -18.588 5.067   1.00 24.59 ?  228 SER A O   1 
ATOM   1804 C CB  . SER A 1 264 ? 17.593  -17.965 7.438   1.00 27.60 ?  228 SER A CB  1 
ATOM   1805 O OG  . SER A 1 264 ? 18.487  -19.011 7.109   1.00 26.45 ?  228 SER A OG  1 
ATOM   1806 N N   . MET A 1 265 ? 17.613  -18.684 4.261   1.00 23.61 ?  229 MET A N   1 
ATOM   1807 C CA  . MET A 1 265 ? 17.259  -19.609 3.192   1.00 23.74 ?  229 MET A CA  1 
ATOM   1808 C C   . MET A 1 265 ? 17.876  -20.976 3.441   1.00 25.73 ?  229 MET A C   1 
ATOM   1809 O O   . MET A 1 265 ? 19.043  -21.087 3.813   1.00 27.85 ?  229 MET A O   1 
ATOM   1810 C CB  . MET A 1 265 ? 17.704  -19.089 1.812   1.00 26.88 ?  229 MET A CB  1 
ATOM   1811 C CG  . MET A 1 265 ? 17.857  -20.174 0.732   1.00 24.85 ?  229 MET A CG  1 
ATOM   1812 S SD  . MET A 1 265 ? 18.489  -19.540 -0.850  1.00 28.60 ?  229 MET A SD  1 
ATOM   1813 C CE  . MET A 1 265 ? 17.042  -18.827 -1.602  1.00 28.39 ?  229 MET A CE  1 
ATOM   1814 N N   . PHE A 1 266 ? 17.082  -22.012 3.219   1.00 25.61 ?  230 PHE A N   1 
ATOM   1815 C CA  . PHE A 1 266 ? 17.551  -23.393 3.233   1.00 26.10 ?  230 PHE A CA  1 
ATOM   1816 C C   . PHE A 1 266 ? 17.860  -23.740 1.793   1.00 27.36 ?  230 PHE A C   1 
ATOM   1817 O O   . PHE A 1 266 ? 16.947  -23.970 0.994   1.00 29.42 ?  230 PHE A O   1 
ATOM   1818 C CB  . PHE A 1 266 ? 16.485  -24.316 3.803   1.00 23.46 ?  230 PHE A CB  1 
ATOM   1819 C CG  . PHE A 1 266 ? 16.091  -23.974 5.202   1.00 26.63 ?  230 PHE A CG  1 
ATOM   1820 C CD1 . PHE A 1 266 ? 15.125  -23.009 5.449   1.00 28.63 ?  230 PHE A CD1 1 
ATOM   1821 C CD2 . PHE A 1 266 ? 16.690  -24.616 6.276   1.00 26.22 ?  230 PHE A CD2 1 
ATOM   1822 C CE1 . PHE A 1 266 ? 14.768  -22.685 6.755   1.00 29.48 ?  230 PHE A CE1 1 
ATOM   1823 C CE2 . PHE A 1 266 ? 16.334  -24.307 7.581   1.00 24.00 ?  230 PHE A CE2 1 
ATOM   1824 C CZ  . PHE A 1 266 ? 15.373  -23.343 7.823   1.00 29.44 ?  230 PHE A CZ  1 
ATOM   1825 N N   . GLU A 1 267 ? 19.141  -23.714 1.426   1.00 30.84 ?  231 GLU A N   1 
ATOM   1826 C CA  . GLU A 1 267 ? 19.519  -23.818 -0.013  1.00 31.04 ?  231 GLU A CA  1 
ATOM   1827 C C   . GLU A 1 267 ? 19.425  -25.235 -0.591  1.00 30.11 ?  231 GLU A C   1 
ATOM   1828 O O   . GLU A 1 267 ? 19.306  -25.348 -1.815  1.00 28.85 ?  231 GLU A O   1 
ATOM   1829 C CB  . GLU A 1 267 ? 20.917  -23.251 -0.224  1.00 29.61 ?  231 GLU A CB  1 
ATOM   1830 C CG  . GLU A 1 267 ? 21.218  -22.904 -1.666  1.00 30.00 ?  231 GLU A CG  1 
ATOM   1831 C CD  . GLU A 1 267 ? 22.692  -22.665 -1.928  1.00 31.61 ?  231 GLU A CD  1 
ATOM   1832 O OE1 . GLU A 1 267 ? 23.421  -22.407 -0.961  1.00 29.12 ?  231 GLU A OE1 1 
ATOM   1833 O OE2 . GLU A 1 267 ? 23.097  -22.740 -3.095  1.00 32.62 ?  231 GLU A OE2 1 
ATOM   1834 N N   . HIS A 1 268 ? 19.490  -26.253 0.257   1.00 27.48 ?  232 HIS A N   1 
ATOM   1835 C CA  . HIS A 1 268 ? 19.450  -27.634 -0.227  1.00 28.21 ?  232 HIS A CA  1 
ATOM   1836 C C   . HIS A 1 268 ? 20.355  -27.829 -1.444  1.00 34.25 ?  232 HIS A C   1 
ATOM   1837 O O   . HIS A 1 268 ? 19.938  -28.339 -2.486  1.00 30.90 ?  232 HIS A O   1 
ATOM   1838 C CB  . HIS A 1 268 ? 18.014  -28.047 -0.540  1.00 25.63 ?  232 HIS A CB  1 
ATOM   1839 C CG  . HIS A 1 268 ? 17.116  -28.006 0.657   1.00 27.09 ?  232 HIS A CG  1 
ATOM   1840 N ND1 . HIS A 1 268 ? 16.191  -27.005 0.859   1.00 25.14 ?  232 HIS A ND1 1 
ATOM   1841 C CD2 . HIS A 1 268 ? 17.048  -28.811 1.746   1.00 25.94 ?  232 HIS A CD2 1 
ATOM   1842 C CE1 . HIS A 1 268 ? 15.567  -27.214 2.006   1.00 28.70 ?  232 HIS A CE1 1 
ATOM   1843 N NE2 . HIS A 1 268 ? 16.071  -28.301 2.565   1.00 26.41 ?  232 HIS A NE2 1 
ATOM   1844 N N   . TYR A 1 269 ? 21.615  -27.408 -1.303  1.00 34.31 ?  233 TYR A N   1 
ATOM   1845 C CA  . TYR A 1 269 ? 22.531  -27.355 -2.444  1.00 35.76 ?  233 TYR A CA  1 
ATOM   1846 C C   . TYR A 1 269 ? 23.152  -28.696 -2.810  1.00 38.70 ?  233 TYR A C   1 
ATOM   1847 O O   . TYR A 1 269 ? 23.904  -28.756 -3.788  1.00 43.90 ?  233 TYR A O   1 
ATOM   1848 C CB  . TYR A 1 269 ? 23.656  -26.345 -2.197  1.00 32.75 ?  233 TYR A CB  1 
ATOM   1849 C CG  . TYR A 1 269 ? 24.335  -26.410 -0.841  1.00 33.96 ?  233 TYR A CG  1 
ATOM   1850 C CD1 . TYR A 1 269 ? 25.443  -27.232 -0.613  1.00 33.65 ?  233 TYR A CD1 1 
ATOM   1851 C CD2 . TYR A 1 269 ? 23.901  -25.602 0.194   1.00 32.25 ?  233 TYR A CD2 1 
ATOM   1852 C CE1 . TYR A 1 269 ? 26.072  -27.254 0.639   1.00 31.53 ?  233 TYR A CE1 1 
ATOM   1853 C CE2 . TYR A 1 269 ? 24.508  -25.618 1.430   1.00 35.60 ?  233 TYR A CE2 1 
ATOM   1854 C CZ  . TYR A 1 269 ? 25.587  -26.440 1.658   1.00 36.98 ?  233 TYR A CZ  1 
ATOM   1855 O OH  . TYR A 1 269 ? 26.149  -26.418 2.926   1.00 41.77 ?  233 TYR A OH  1 
ATOM   1856 N N   . ASN A 1 270 ? 22.889  -29.758 -2.057  1.00 36.63 ?  234 ASN A N   1 
ATOM   1857 C CA  . ASN A 1 270 ? 23.397  -31.077 -2.398  1.00 38.95 ?  234 ASN A CA  1 
ATOM   1858 C C   . ASN A 1 270 ? 22.445  -32.098 -1.797  1.00 41.59 ?  234 ASN A C   1 
ATOM   1859 O O   . ASN A 1 270 ? 21.448  -31.736 -1.168  1.00 40.23 ?  234 ASN A O   1 
ATOM   1860 C CB  . ASN A 1 270 ? 24.849  -31.257 -1.922  1.00 38.58 ?  234 ASN A CB  1 
ATOM   1861 C CG  . ASN A 1 270 ? 24.977  -31.347 -0.399  1.00 41.70 ?  234 ASN A CG  1 
ATOM   1862 O OD1 . ASN A 1 270 ? 24.040  -31.730 0.305   1.00 38.36 ?  234 ASN A OD1 1 
ATOM   1863 N ND2 . ASN A 1 270 ? 26.151  -30.991 0.114   1.00 39.60 ?  234 ASN A ND2 1 
ATOM   1864 N N   . GLU A 1 271 ? 22.777  -33.385 -1.946  1.00 42.66 ?  235 GLU A N   1 
ATOM   1865 C CA  . GLU A 1 271 ? 21.849  -34.435 -1.534  1.00 42.52 ?  235 GLU A CA  1 
ATOM   1866 C C   . GLU A 1 271 ? 21.936  -34.792 -0.056  1.00 38.50 ?  235 GLU A C   1 
ATOM   1867 O O   . GLU A 1 271 ? 20.983  -35.370 0.480   1.00 37.33 ?  235 GLU A O   1 
ATOM   1868 C CB  . GLU A 1 271 ? 22.047  -35.707 -2.377  1.00 49.01 ?  235 GLU A CB  1 
ATOM   1869 C CG  . GLU A 1 271 ? 23.396  -36.402 -2.239  1.00 49.84 ?  235 GLU A CG  1 
ATOM   1870 C CD  . GLU A 1 271 ? 23.726  -37.277 -3.455  1.00 63.93 ?  235 GLU A CD  1 
ATOM   1871 O OE1 . GLU A 1 271 ? 24.923  -37.355 -3.842  1.00 63.94 ?  235 GLU A OE1 1 
ATOM   1872 O OE2 . GLU A 1 271 ? 22.783  -37.890 -4.021  1.00 55.98 ?  235 GLU A OE2 1 
ATOM   1873 N N   . LYS A 1 272 ? 23.038  -34.474 0.627   1.00 36.36 ?  236 LYS A N   1 
ATOM   1874 C CA  . LYS A 1 272 ? 23.044  -34.662 2.075   1.00 39.76 ?  236 LYS A CA  1 
ATOM   1875 C C   . LYS A 1 272 ? 22.033  -33.737 2.750   1.00 34.89 ?  236 LYS A C   1 
ATOM   1876 O O   . LYS A 1 272 ? 21.439  -34.102 3.771   1.00 35.05 ?  236 LYS A O   1 
ATOM   1877 C CB  . LYS A 1 272 ? 24.453  -34.443 2.636   1.00 36.25 ?  236 LYS A CB  1 
ATOM   1878 C CG  . LYS A 1 272 ? 24.510  -34.072 4.115   1.00 34.83 ?  236 LYS A CG  1 
ATOM   1879 C CD  . LYS A 1 272 ? 24.417  -35.294 5.023   1.00 41.57 ?  236 LYS A CD  1 
ATOM   1880 C CE  . LYS A 1 272 ? 24.390  -34.871 6.488   1.00 44.77 ?  236 LYS A CE  1 
ATOM   1881 N NZ  . LYS A 1 272 ? 25.749  -34.797 7.107   1.00 48.71 ?  236 LYS A NZ  1 
ATOM   1882 N N   . LEU A 1 273 ? 21.807  -32.550 2.183   1.00 33.62 ?  237 LEU A N   1 
ATOM   1883 C CA  . LEU A 1 273 ? 20.846  -31.602 2.735   1.00 33.07 ?  237 LEU A CA  1 
ATOM   1884 C C   . LEU A 1 273 ? 19.403  -31.971 2.430   1.00 30.27 ?  237 LEU A C   1 
ATOM   1885 O O   . LEU A 1 273 ? 18.490  -31.290 2.919   1.00 31.20 ?  237 LEU A O   1 
ATOM   1886 C CB  . LEU A 1 273 ? 21.114  -30.194 2.199   1.00 31.35 ?  237 LEU A CB  1 
ATOM   1887 C CG  . LEU A 1 273 ? 22.374  -29.492 2.669   1.00 32.72 ?  237 LEU A CG  1 
ATOM   1888 C CD1 . LEU A 1 273 ? 22.457  -28.186 1.940   1.00 34.45 ?  237 LEU A CD1 1 
ATOM   1889 C CD2 . LEU A 1 273 ? 22.344  -29.277 4.170   1.00 34.82 ?  237 LEU A CD2 1 
ATOM   1890 N N   . LEU A 1 274 ? 19.182  -32.984 1.597   1.00 32.05 ?  238 LEU A N   1 
ATOM   1891 C CA  . LEU A 1 274 ? 17.855  -33.503 1.295   1.00 30.64 ?  238 LEU A CA  1 
ATOM   1892 C C   . LEU A 1 274 ? 17.622  -34.874 1.913   1.00 32.39 ?  238 LEU A C   1 
ATOM   1893 O O   . LEU A 1 274 ? 16.620  -35.522 1.603   1.00 33.33 ?  238 LEU A O   1 
ATOM   1894 C CB  . LEU A 1 274 ? 17.639  -33.563 -0.218  1.00 30.81 ?  238 LEU A CB  1 
ATOM   1895 C CG  . LEU A 1 274 ? 17.528  -32.211 -0.917  1.00 31.77 ?  238 LEU A CG  1 
ATOM   1896 C CD1 . LEU A 1 274 ? 17.807  -32.332 -2.404  1.00 32.97 ?  238 LEU A CD1 1 
ATOM   1897 C CD2 . LEU A 1 274 ? 16.140  -31.607 -0.673  1.00 36.28 ?  238 LEU A CD2 1 
ATOM   1898 N N   . SER A 1 275 ? 18.517  -35.321 2.785   1.00 33.45 ?  239 SER A N   1 
ATOM   1899 C CA  . SER A 1 275 ? 18.330  -36.558 3.517   1.00 32.46 ?  239 SER A CA  1 
ATOM   1900 C C   . SER A 1 275 ? 17.126  -36.448 4.447   1.00 37.17 ?  239 SER A C   1 
ATOM   1901 O O   . SER A 1 275 ? 16.616  -35.361 4.718   1.00 31.30 ?  239 SER A O   1 
ATOM   1902 C CB  . SER A 1 275 ? 19.573  -36.871 4.336   1.00 34.86 ?  239 SER A CB  1 
ATOM   1903 O OG  . SER A 1 275 ? 19.734  -35.884 5.339   1.00 34.04 ?  239 SER A OG  1 
ATOM   1904 N N   . LYS A 1 276 ? 16.687  -37.600 4.966   1.00 36.62 ?  240 LYS A N   1 
ATOM   1905 C CA  . LYS A 1 276 ? 15.567  -37.589 5.904   1.00 38.01 ?  240 LYS A CA  1 
ATOM   1906 C C   . LYS A 1 276 ? 15.934  -36.852 7.190   1.00 35.46 ?  240 LYS A C   1 
ATOM   1907 O O   . LYS A 1 276 ? 15.109  -36.125 7.761   1.00 33.57 ?  240 LYS A O   1 
ATOM   1908 C CB  . LYS A 1 276 ? 15.093  -39.026 6.188   1.00 39.57 ?  240 LYS A CB  1 
ATOM   1909 C CG  . LYS A 1 276 ? 15.940  -39.856 7.155   1.00 38.15 ?  240 LYS A CG  1 
ATOM   1910 C CD  . LYS A 1 276 ? 15.702  -41.354 6.921   1.00 43.90 ?  240 LYS A CD  1 
ATOM   1911 C CE  . LYS A 1 276 ? 16.701  -42.239 7.678   1.00 40.92 ?  240 LYS A CE  1 
ATOM   1912 N NZ  . LYS A 1 276 ? 18.004  -42.354 6.943   1.00 39.64 ?  240 LYS A NZ  1 
ATOM   1913 N N   . GLU A 1 277 ? 17.180  -36.997 7.639   1.00 36.73 ?  241 GLU A N   1 
ATOM   1914 C CA  . GLU A 1 277 ? 17.639  -36.282 8.824   1.00 35.64 ?  241 GLU A CA  1 
ATOM   1915 C C   . GLU A 1 277 ? 17.683  -34.770 8.587   1.00 38.88 ?  241 GLU A C   1 
ATOM   1916 O O   . GLU A 1 277 ? 17.243  -33.990 9.443   1.00 33.94 ?  241 GLU A O   1 
ATOM   1917 C CB  . GLU A 1 277 ? 19.014  -36.809 9.239   1.00 37.66 ?  241 GLU A CB  1 
ATOM   1918 C CG  . GLU A 1 277 ? 19.040  -38.306 9.581   1.00 38.24 ?  241 GLU A CG  1 
ATOM   1919 C CD  . GLU A 1 277 ? 19.120  -39.211 8.350   1.00 41.70 ?  241 GLU A CD  1 
ATOM   1920 O OE1 . GLU A 1 277 ? 19.259  -38.688 7.222   1.00 37.29 ?  241 GLU A OE1 1 
ATOM   1921 O OE2 . GLU A 1 277 ? 19.033  -40.451 8.508   1.00 42.40 ?  241 GLU A OE2 1 
ATOM   1922 N N   . SER A 1 278 ? 18.209  -34.337 7.432   1.00 34.45 ?  242 SER A N   1 
ATOM   1923 C CA  . SER A 1 278 ? 18.306  -32.905 7.144   1.00 34.55 ?  242 SER A CA  1 
ATOM   1924 C C   . SER A 1 278 ? 16.930  -32.281 6.986   1.00 32.33 ?  242 SER A C   1 
ATOM   1925 O O   . SER A 1 278 ? 16.700  -31.150 7.436   1.00 29.81 ?  242 SER A O   1 
ATOM   1926 C CB  . SER A 1 278 ? 19.124  -32.660 5.875   1.00 30.95 ?  242 SER A CB  1 
ATOM   1927 O OG  . SER A 1 278 ? 20.379  -33.309 5.931   1.00 34.13 ?  242 SER A OG  1 
ATOM   1928 N N   . LEU A 1 279 ? 16.007  -32.992 6.327   1.00 31.95 ?  243 LEU A N   1 
ATOM   1929 C CA  . LEU A 1 279 ? 14.660  -32.459 6.145   1.00 29.70 ?  243 LEU A CA  1 
ATOM   1930 C C   . LEU A 1 279 ? 13.961  -32.257 7.485   1.00 30.73 ?  243 LEU A C   1 
ATOM   1931 O O   . LEU A 1 279 ? 13.258  -31.254 7.687   1.00 29.62 ?  243 LEU A O   1 
ATOM   1932 C CB  . LEU A 1 279 ? 13.857  -33.385 5.240   1.00 29.45 ?  243 LEU A CB  1 
ATOM   1933 C CG  . LEU A 1 279 ? 14.272  -33.256 3.776   1.00 31.57 ?  243 LEU A CG  1 
ATOM   1934 C CD1 . LEU A 1 279 ? 13.527  -34.253 2.944   1.00 33.54 ?  243 LEU A CD1 1 
ATOM   1935 C CD2 . LEU A 1 279 ? 14.014  -31.836 3.278   1.00 31.34 ?  243 LEU A CD2 1 
ATOM   1936 N N   . LEU A 1 280 ? 14.136  -33.201 8.410   1.00 28.67 ?  244 LEU A N   1 
ATOM   1937 C CA  . LEU A 1 280 ? 13.540  -33.046 9.731   1.00 27.09 ?  244 LEU A CA  1 
ATOM   1938 C C   . LEU A 1 280 ? 14.182  -31.888 10.473  1.00 30.27 ?  244 LEU A C   1 
ATOM   1939 O O   . LEU A 1 280 ? 13.504  -31.156 11.205  1.00 26.67 ?  244 LEU A O   1 
ATOM   1940 C CB  . LEU A 1 280 ? 13.671  -34.347 10.525  1.00 29.90 ?  244 LEU A CB  1 
ATOM   1941 C CG  . LEU A 1 280 ? 13.391  -34.295 12.027  1.00 31.07 ?  244 LEU A CG  1 
ATOM   1942 C CD1 . LEU A 1 280 ? 11.933  -33.956 12.267  1.00 30.90 ?  244 LEU A CD1 1 
ATOM   1943 C CD2 . LEU A 1 280 ? 13.768  -35.609 12.728  1.00 30.43 ?  244 LEU A CD2 1 
ATOM   1944 N N   . GLN A 1 281 ? 15.496  -31.715 10.294  1.00 32.14 ?  245 GLN A N   1 
ATOM   1945 C CA  . GLN A 1 281 ? 16.186  -30.558 10.852  1.00 28.13 ?  245 GLN A CA  1 
ATOM   1946 C C   . GLN A 1 281 ? 15.710  -29.259 10.202  1.00 27.30 ?  245 GLN A C   1 
ATOM   1947 O O   . GLN A 1 281 ? 15.545  -28.246 10.888  1.00 22.44 ?  245 GLN A O   1 
ATOM   1948 C CB  . GLN A 1 281 ? 17.701  -30.718 10.685  1.00 30.51 ?  245 GLN A CB  1 
ATOM   1949 C CG  . GLN A 1 281 ? 18.525  -29.600 11.334  1.00 30.66 ?  245 GLN A CG  1 
ATOM   1950 C CD  . GLN A 1 281 ? 18.400  -29.595 12.844  1.00 38.03 ?  245 GLN A CD  1 
ATOM   1951 O OE1 . GLN A 1 281 ? 18.267  -30.646 13.458  1.00 43.77 ?  245 GLN A OE1 1 
ATOM   1952 N NE2 . GLN A 1 281 ? 18.418  -28.410 13.448  1.00 34.46 ?  245 GLN A NE2 1 
ATOM   1953 N N   . ASP A 1 282 ? 15.525  -29.253 8.878   1.00 26.73 ?  246 ASP A N   1 
ATOM   1954 C CA  . ASP A 1 282 ? 14.876  -28.105 8.242   1.00 25.92 ?  246 ASP A CA  1 
ATOM   1955 C C   . ASP A 1 282 ? 13.615  -27.718 9.008   1.00 28.05 ?  246 ASP A C   1 
ATOM   1956 O O   . ASP A 1 282 ? 13.435  -26.557 9.407   1.00 24.63 ?  246 ASP A O   1 
ATOM   1957 C CB  . ASP A 1 282 ? 14.508  -28.419 6.787   1.00 28.11 ?  246 ASP A CB  1 
ATOM   1958 C CG  . ASP A 1 282 ? 15.711  -28.469 5.846   1.00 25.96 ?  246 ASP A CG  1 
ATOM   1959 O OD1 . ASP A 1 282 ? 16.801  -28.013 6.210   1.00 22.48 ?  246 ASP A OD1 1 
ATOM   1960 O OD2 . ASP A 1 282 ? 15.548  -28.967 4.706   1.00 28.14 ?  246 ASP A OD2 1 
ATOM   1961 N N   . TRP A 1 283 ? 12.749  -28.702 9.258   1.00 23.77 ?  247 TRP A N   1 
ATOM   1962 C CA  . TRP A 1 283 ? 11.443  -28.406 9.829   1.00 25.99 ?  247 TRP A CA  1 
ATOM   1963 C C   . TRP A 1 283 ? 11.581  -27.854 11.235  1.00 23.48 ?  247 TRP A C   1 
ATOM   1964 O O   . TRP A 1 283 ? 10.887  -26.901 11.601  1.00 24.63 ?  247 TRP A O   1 
ATOM   1965 C CB  . TRP A 1 283 ? 10.558  -29.661 9.806   1.00 23.80 ?  247 TRP A CB  1 
ATOM   1966 C CG  . TRP A 1 283 ? 10.353  -30.220 8.424   1.00 25.76 ?  247 TRP A CG  1 
ATOM   1967 C CD1 . TRP A 1 283 ? 10.367  -29.525 7.246   1.00 26.57 ?  247 TRP A CD1 1 
ATOM   1968 C CD2 . TRP A 1 283 ? 10.095  -31.583 8.079   1.00 26.06 ?  247 TRP A CD2 1 
ATOM   1969 N NE1 . TRP A 1 283 ? 10.137  -30.374 6.190   1.00 21.28 ?  247 TRP A NE1 1 
ATOM   1970 C CE2 . TRP A 1 283 ? 9.977   -31.645 6.676   1.00 27.05 ?  247 TRP A CE2 1 
ATOM   1971 C CE3 . TRP A 1 283 ? 9.977   -32.764 8.818   1.00 30.11 ?  247 TRP A CE3 1 
ATOM   1972 C CZ2 . TRP A 1 283 ? 9.727   -32.835 6.002   1.00 26.44 ?  247 TRP A CZ2 1 
ATOM   1973 C CZ3 . TRP A 1 283 ? 9.742   -33.950 8.143   1.00 26.10 ?  247 TRP A CZ3 1 
ATOM   1974 C CH2 . TRP A 1 283 ? 9.616   -33.974 6.752   1.00 28.95 ?  247 TRP A CH2 1 
ATOM   1975 N N   . ASP A 1 284 ? 12.496  -28.412 12.033  1.00 26.43 ?  248 ASP A N   1 
ATOM   1976 C CA  . ASP A 1 284 ? 12.749  -27.809 13.341  1.00 26.95 ?  248 ASP A CA  1 
ATOM   1977 C C   . ASP A 1 284 ? 13.283  -26.393 13.189  1.00 28.84 ?  248 ASP A C   1 
ATOM   1978 O O   . ASP A 1 284 ? 12.846  -25.480 13.902  1.00 28.77 ?  248 ASP A O   1 
ATOM   1979 C CB  . ASP A 1 284 ? 13.740  -28.638 14.152  1.00 27.77 ?  248 ASP A CB  1 
ATOM   1980 C CG  . ASP A 1 284 ? 13.244  -30.045 14.437  1.00 35.06 ?  248 ASP A CG  1 
ATOM   1981 O OD1 . ASP A 1 284 ? 12.008  -30.310 14.348  1.00 27.66 ?  248 ASP A OD1 1 
ATOM   1982 O OD2 . ASP A 1 284 ? 14.113  -30.877 14.790  1.00 35.23 ?  248 ASP A OD2 1 
ATOM   1983 N N   . ASP A 1 285 ? 14.240  -26.193 12.269  1.00 27.18 ?  249 ASP A N   1 
ATOM   1984 C CA  . ASP A 1 285 ? 14.778  -24.850 12.036  1.00 28.65 ?  249 ASP A CA  1 
ATOM   1985 C C   . ASP A 1 285 ? 13.680  -23.881 11.619  1.00 22.59 ?  249 ASP A C   1 
ATOM   1986 O O   . ASP A 1 285 ? 13.644  -22.735 12.079  1.00 25.52 ?  249 ASP A O   1 
ATOM   1987 C CB  . ASP A 1 285 ? 15.861  -24.874 10.953  1.00 27.48 ?  249 ASP A CB  1 
ATOM   1988 C CG  . ASP A 1 285 ? 17.139  -25.567 11.396  1.00 30.71 ?  249 ASP A CG  1 
ATOM   1989 O OD1 . ASP A 1 285 ? 17.346  -25.748 12.616  1.00 31.97 ?  249 ASP A OD1 1 
ATOM   1990 O OD2 . ASP A 1 285 ? 17.952  -25.918 10.506  1.00 32.31 ?  249 ASP A OD2 1 
ATOM   1991 N N   . MET A 1 286 ? 12.780  -24.319 10.737  1.00 26.81 ?  250 MET A N   1 
ATOM   1992 C CA  . MET A 1 286 ? 11.733  -23.432 10.235  1.00 22.42 ?  250 MET A CA  1 
ATOM   1993 C C   . MET A 1 286 ? 10.817  -22.944 11.357  1.00 26.43 ?  250 MET A C   1 
ATOM   1994 O O   . MET A 1 286 ? 10.431  -21.766 11.391  1.00 25.78 ?  250 MET A O   1 
ATOM   1995 C CB  . MET A 1 286 ? 10.946  -24.159 9.160   1.00 21.94 ?  250 MET A CB  1 
ATOM   1996 C CG  . MET A 1 286 ? 11.693  -24.250 7.851   1.00 22.50 ?  250 MET A CG  1 
ATOM   1997 S SD  . MET A 1 286 ? 10.927  -25.434 6.748   1.00 27.80 ?  250 MET A SD  1 
ATOM   1998 C CE  . MET A 1 286 ? 9.635   -24.415 6.024   1.00 25.40 ?  250 MET A CE  1 
ATOM   1999 N N   . LEU A 1 287 ? 10.464  -23.836 12.290  1.00 26.43 ?  251 LEU A N   1 
ATOM   2000 C CA  . LEU A 1 287 ? 9.688   -23.434 13.457  1.00 23.02 ?  251 LEU A CA  1 
ATOM   2001 C C   . LEU A 1 287 ? 10.461  -22.440 14.307  1.00 25.56 ?  251 LEU A C   1 
ATOM   2002 O O   . LEU A 1 287 ? 9.911   -21.427 14.752  1.00 25.16 ?  251 LEU A O   1 
ATOM   2003 C CB  . LEU A 1 287 ? 9.315   -24.660 14.293  1.00 25.19 ?  251 LEU A CB  1 
ATOM   2004 C CG  . LEU A 1 287 ? 8.633   -24.353 15.630  1.00 24.19 ?  251 LEU A CG  1 
ATOM   2005 C CD1 . LEU A 1 287 ? 7.359   -23.566 15.406  1.00 23.85 ?  251 LEU A CD1 1 
ATOM   2006 C CD2 . LEU A 1 287 ? 8.330   -25.620 16.377  1.00 22.81 ?  251 LEU A CD2 1 
ATOM   2007 N N   . ARG A 1 288 ? 11.742  -22.729 14.570  1.00 26.31 ?  252 ARG A N   1 
ATOM   2008 C CA  . ARG A 1 288 ? 12.539  -21.820 15.386  1.00 29.13 ?  252 ARG A CA  1 
ATOM   2009 C C   . ARG A 1 288 ? 12.644  -20.451 14.723  1.00 27.47 ?  252 ARG A C   1 
ATOM   2010 O O   . ARG A 1 288 ? 12.500  -19.418 15.383  1.00 27.14 ?  252 ARG A O   1 
ATOM   2011 C CB  . ARG A 1 288 ? 13.927  -22.422 15.646  1.00 30.99 ?  252 ARG A CB  1 
ATOM   2012 C CG  . ARG A 1 288 ? 14.952  -21.421 16.147  1.00 29.91 ?  252 ARG A CG  1 
ATOM   2013 C CD  . ARG A 1 288 ? 16.234  -22.110 16.670  1.00 32.78 ?  252 ARG A CD  1 
ATOM   2014 N NE  . ARG A 1 288 ? 16.914  -22.865 15.624  1.00 33.43 ?  252 ARG A NE  1 
ATOM   2015 C CZ  . ARG A 1 288 ? 17.806  -22.356 14.784  1.00 35.90 ?  252 ARG A CZ  1 
ATOM   2016 N NH1 . ARG A 1 288 ? 18.187  -21.089 14.859  1.00 37.23 ?  252 ARG A NH1 1 
ATOM   2017 N NH2 . ARG A 1 288 ? 18.336  -23.141 13.850  1.00 41.01 ?  252 ARG A NH2 1 
ATOM   2018 N N   . ILE A 1 289 ? 12.856  -20.422 13.407  1.00 26.49 ?  253 ILE A N   1 
ATOM   2019 C CA  . ILE A 1 289 ? 12.934  -19.144 12.703  1.00 27.51 ?  253 ILE A CA  1 
ATOM   2020 C C   . ILE A 1 289 ? 11.628  -18.371 12.855  1.00 27.04 ?  253 ILE A C   1 
ATOM   2021 O O   . ILE A 1 289 ? 11.632  -17.165 13.147  1.00 22.87 ?  253 ILE A O   1 
ATOM   2022 C CB  . ILE A 1 289 ? 13.288  -19.382 11.222  1.00 24.33 ?  253 ILE A CB  1 
ATOM   2023 C CG1 . ILE A 1 289 ? 14.743  -19.826 11.088  1.00 23.96 ?  253 ILE A CG1 1 
ATOM   2024 C CG2 . ILE A 1 289 ? 12.983  -18.141 10.375  1.00 23.78 ?  253 ILE A CG2 1 
ATOM   2025 C CD1 . ILE A 1 289 ? 15.099  -20.238 9.663   1.00 25.13 ?  253 ILE A CD1 1 
ATOM   2026 N N   . ALA A 1 290 ? 10.488  -19.066 12.703  1.00 23.57 ?  254 ALA A N   1 
ATOM   2027 C CA  . ALA A 1 290 ? 9.192   -18.394 12.783  1.00 25.77 ?  254 ALA A CA  1 
ATOM   2028 C C   . ALA A 1 290 ? 8.911   -17.896 14.191  1.00 23.57 ?  254 ALA A C   1 
ATOM   2029 O O   . ALA A 1 290 ? 8.304   -16.835 14.374  1.00 24.64 ?  254 ALA A O   1 
ATOM   2030 C CB  . ALA A 1 290 ? 8.072   -19.333 12.317  1.00 20.29 ?  254 ALA A CB  1 
ATOM   2031 N N   . GLN A 1 291 ? 9.320   -18.660 15.202  1.00 25.27 ?  255 GLN A N   1 
ATOM   2032 C CA  . GLN A 1 291 ? 9.140   -18.202 16.571  1.00 24.87 ?  255 GLN A CA  1 
ATOM   2033 C C   . GLN A 1 291 ? 9.983   -16.971 16.850  1.00 28.19 ?  255 GLN A C   1 
ATOM   2034 O O   . GLN A 1 291 ? 9.656   -16.189 17.745  1.00 29.79 ?  255 GLN A O   1 
ATOM   2035 C CB  . GLN A 1 291 ? 9.476   -19.326 17.544  1.00 23.29 ?  255 GLN A CB  1 
ATOM   2036 C CG  . GLN A 1 291 ? 8.541   -20.541 17.457  1.00 28.26 ?  255 GLN A CG  1 
ATOM   2037 C CD  . GLN A 1 291 ? 9.073   -21.736 18.219  1.00 28.29 ?  255 GLN A CD  1 
ATOM   2038 O OE1 . GLN A 1 291 ? 10.262  -22.044 18.160  1.00 26.85 ?  255 GLN A OE1 1 
ATOM   2039 N NE2 . GLN A 1 291 ? 8.195   -22.414 18.946  1.00 27.14 ?  255 GLN A NE2 1 
ATOM   2040 N N   . ALA A 1 292 ? 11.073  -16.779 16.107  1.00 27.47 ?  256 ALA A N   1 
ATOM   2041 C CA  . ALA A 1 292 ? 11.826  -15.537 16.235  1.00 26.81 ?  256 ALA A CA  1 
ATOM   2042 C C   . ALA A 1 292 ? 11.198  -14.397 15.441  1.00 29.68 ?  256 ALA A C   1 
ATOM   2043 O O   . ALA A 1 292 ? 11.776  -13.306 15.389  1.00 29.95 ?  256 ALA A O   1 
ATOM   2044 C CB  . ALA A 1 292 ? 13.278  -15.750 15.797  1.00 22.80 ?  256 ALA A CB  1 
ATOM   2045 N N   . GLY A 1 293 ? 10.028  -14.621 14.834  1.00 26.48 ?  257 GLY A N   1 
ATOM   2046 C CA  . GLY A 1 293 ? 9.422   -13.617 13.981  1.00 22.22 ?  257 GLY A CA  1 
ATOM   2047 C C   . GLY A 1 293 ? 10.160  -13.381 12.686  1.00 27.06 ?  257 GLY A C   1 
ATOM   2048 O O   . GLY A 1 293 ? 9.987   -12.326 12.068  1.00 28.76 ?  257 GLY A O   1 
ATOM   2049 N N   . LYS A 1 294 ? 10.984  -14.332 12.259  1.00 22.52 ?  258 LYS A N   1 
ATOM   2050 C CA  . LYS A 1 294 ? 11.765  -14.216 11.040  1.00 23.29 ?  258 LYS A CA  1 
ATOM   2051 C C   . LYS A 1 294 ? 11.140  -15.044 9.924   1.00 26.05 ?  258 LYS A C   1 
ATOM   2052 O O   . LYS A 1 294 ? 10.229  -15.860 10.134  1.00 21.50 ?  258 LYS A O   1 
ATOM   2053 C CB  . LYS A 1 294 ? 13.202  -14.682 11.268  1.00 27.33 ?  258 LYS A CB  1 
ATOM   2054 C CG  . LYS A 1 294 ? 14.038  -13.842 12.207  1.00 27.11 ?  258 LYS A CG  1 
ATOM   2055 C CD  . LYS A 1 294 ? 15.392  -14.509 12.371  1.00 28.98 ?  258 LYS A CD  1 
ATOM   2056 C CE  . LYS A 1 294 ? 16.165  -13.906 13.517  1.00 32.78 ?  258 LYS A CE  1 
ATOM   2057 N NZ  . LYS A 1 294 ? 15.955  -12.431 13.557  1.00 25.75 ?  258 LYS A NZ  1 
ATOM   2058 N N   . MET A 1 295 ? 11.673  -14.839 8.727   1.00 23.82 ?  259 MET A N   1 
ATOM   2059 C CA  . MET A 1 295 ? 11.188  -15.458 7.513   1.00 22.41 ?  259 MET A CA  1 
ATOM   2060 C C   . MET A 1 295 ? 12.151  -16.564 7.116   1.00 24.95 ?  259 MET A C   1 
ATOM   2061 O O   . MET A 1 295 ? 13.350  -16.504 7.394   1.00 23.09 ?  259 MET A O   1 
ATOM   2062 C CB  . MET A 1 295 ? 11.095  -14.430 6.394   1.00 25.17 ?  259 MET A CB  1 
ATOM   2063 C CG  . MET A 1 295 ? 10.222  -13.206 6.725   1.00 20.23 ?  259 MET A CG  1 
ATOM   2064 S SD  . MET A 1 295 ? 9.836   -12.295 5.229   1.00 25.63 ?  259 MET A SD  1 
ATOM   2065 C CE  . MET A 1 295 ? 11.253  -11.165 5.173   1.00 18.01 ?  259 MET A CE  1 
ATOM   2066 N N   . SER A 1 296 ? 11.639  -17.578 6.448   1.00 22.43 ?  260 SER A N   1 
ATOM   2067 C CA  . SER A 1 296 ? 12.537  -18.577 5.898   1.00 25.22 ?  260 SER A CA  1 
ATOM   2068 C C   . SER A 1 296 ? 12.162  -18.842 4.449   1.00 24.00 ?  260 SER A C   1 
ATOM   2069 O O   . SER A 1 296 ? 11.004  -18.698 4.048   1.00 22.33 ?  260 SER A O   1 
ATOM   2070 C CB  . SER A 1 296 ? 12.519  -19.864 6.731   1.00 24.14 ?  260 SER A CB  1 
ATOM   2071 O OG  . SER A 1 296 ? 11.279  -20.509 6.609   1.00 26.85 ?  260 SER A OG  1 
ATOM   2072 N N   . ILE A 1 297 ? 13.170  -19.177 3.657   1.00 21.96 ?  261 ILE A N   1 
ATOM   2073 C CA  . ILE A 1 297 ? 12.987  -19.570 2.269   1.00 22.11 ?  261 ILE A CA  1 
ATOM   2074 C C   . ILE A 1 297 ? 13.439  -21.020 2.166   1.00 23.08 ?  261 ILE A C   1 
ATOM   2075 O O   . ILE A 1 297 ? 14.602  -21.336 2.436   1.00 24.88 ?  261 ILE A O   1 
ATOM   2076 C CB  . ILE A 1 297 ? 13.772  -18.679 1.291   1.00 26.13 ?  261 ILE A CB  1 
ATOM   2077 C CG1 . ILE A 1 297 ? 13.108  -17.302 1.137   1.00 25.91 ?  261 ILE A CG1 1 
ATOM   2078 C CG2 . ILE A 1 297 ? 13.765  -19.320 -0.085  1.00 23.46 ?  261 ILE A CG2 1 
ATOM   2079 C CD1 . ILE A 1 297 ? 13.249  -16.387 2.306   1.00 27.82 ?  261 ILE A CD1 1 
ATOM   2080 N N   . PHE A 1 298 ? 12.518  -21.898 1.817   1.00 23.74 ?  262 PHE A N   1 
ATOM   2081 C CA  . PHE A 1 298 ? 12.807  -23.320 1.641   1.00 26.05 ?  262 PHE A CA  1 
ATOM   2082 C C   . PHE A 1 298 ? 13.029  -23.517 0.142   1.00 24.56 ?  262 PHE A C   1 
ATOM   2083 O O   . PHE A 1 298 ? 12.073  -23.545 -0.635  1.00 26.46 ?  262 PHE A O   1 
ATOM   2084 C CB  . PHE A 1 298 ? 11.648  -24.149 2.190   1.00 26.60 ?  262 PHE A CB  1 
ATOM   2085 C CG  . PHE A 1 298 ? 11.912  -25.633 2.245   1.00 23.56 ?  262 PHE A CG  1 
ATOM   2086 C CD1 . PHE A 1 298 ? 11.737  -26.419 1.119   1.00 22.23 ?  262 PHE A CD1 1 
ATOM   2087 C CD2 . PHE A 1 298 ? 12.293  -26.238 3.432   1.00 26.24 ?  262 PHE A CD2 1 
ATOM   2088 C CE1 . PHE A 1 298 ? 11.968  -27.803 1.160   1.00 27.70 ?  262 PHE A CE1 1 
ATOM   2089 C CE2 . PHE A 1 298 ? 12.517  -27.615 3.491   1.00 28.12 ?  262 PHE A CE2 1 
ATOM   2090 C CZ  . PHE A 1 298 ? 12.354  -28.394 2.351   1.00 26.93 ?  262 PHE A CZ  1 
ATOM   2091 N N   . ARG A 1 299 ? 14.289  -23.571 -0.282  1.00 26.65 ?  263 ARG A N   1 
ATOM   2092 C CA  . ARG A 1 299 ? 14.602  -23.587 -1.707  1.00 27.25 ?  263 ARG A CA  1 
ATOM   2093 C C   . ARG A 1 299 ? 14.996  -24.986 -2.141  1.00 27.06 ?  263 ARG A C   1 
ATOM   2094 O O   . ARG A 1 299 ? 15.799  -25.644 -1.476  1.00 26.77 ?  263 ARG A O   1 
ATOM   2095 C CB  . ARG A 1 299 ? 15.739  -22.624 -2.060  1.00 30.22 ?  263 ARG A CB  1 
ATOM   2096 C CG  . ARG A 1 299 ? 16.173  -22.736 -3.543  1.00 29.72 ?  263 ARG A CG  1 
ATOM   2097 C CD  . ARG A 1 299 ? 17.367  -23.698 -3.736  1.00 28.99 ?  263 ARG A CD  1 
ATOM   2098 N NE  . ARG A 1 299 ? 17.670  -23.904 -5.149  1.00 32.24 ?  263 ARG A NE  1 
ATOM   2099 C CZ  . ARG A 1 299 ? 18.727  -24.564 -5.616  1.00 35.51 ?  263 ARG A CZ  1 
ATOM   2100 N NH1 . ARG A 1 299 ? 19.564  -25.206 -4.810  1.00 29.31 ?  263 ARG A NH1 1 
ATOM   2101 N NH2 . ARG A 1 299 ? 18.955  -24.572 -6.928  1.00 34.48 ?  263 ARG A NH2 1 
ATOM   2102 N N   . ILE A 1 300 ? 14.457  -25.414 -3.282  1.00 28.15 ?  264 ILE A N   1 
ATOM   2103 C CA  . ILE A 1 300 ? 14.749  -26.721 -3.858  1.00 28.68 ?  264 ILE A CA  1 
ATOM   2104 C C   . ILE A 1 300 ? 15.329  -26.512 -5.245  1.00 33.90 ?  264 ILE A C   1 
ATOM   2105 O O   . ILE A 1 300 ? 14.726  -25.829 -6.083  1.00 30.43 ?  264 ILE A O   1 
ATOM   2106 C CB  . ILE A 1 300 ? 13.499  -27.619 -3.928  1.00 28.23 ?  264 ILE A CB  1 
ATOM   2107 C CG1 . ILE A 1 300 ? 13.116  -28.141 -2.538  1.00 24.93 ?  264 ILE A CG1 1 
ATOM   2108 C CG2 . ILE A 1 300 ? 13.735  -28.773 -4.890  1.00 31.00 ?  264 ILE A CG2 1 
ATOM   2109 C CD1 . ILE A 1 300 ? 14.285  -28.391 -1.630  1.00 29.40 ?  264 ILE A CD1 1 
ATOM   2110 N N   . GLY A 1 301 ? 16.504  -27.079 -5.477  1.00 33.09 ?  265 GLY A N   1 
ATOM   2111 C CA  . GLY A 1 301 ? 17.004  -27.184 -6.825  1.00 35.66 ?  265 GLY A CA  1 
ATOM   2112 C C   . GLY A 1 301 ? 17.073  -28.645 -7.203  1.00 40.91 ?  265 GLY A C   1 
ATOM   2113 O O   . GLY A 1 301 ? 17.833  -29.402 -6.590  1.00 40.03 ?  265 GLY A O   1 
ATOM   2114 N N   . VAL A 1 302 ? 16.296  -29.061 -8.207  1.00 38.75 ?  266 VAL A N   1 
ATOM   2115 C CA  . VAL A 1 302 ? 16.195  -30.482 -8.516  1.00 43.02 ?  266 VAL A CA  1 
ATOM   2116 C C   . VAL A 1 302 ? 17.466  -30.977 -9.198  1.00 47.05 ?  266 VAL A C   1 
ATOM   2117 O O   . VAL A 1 302 ? 17.605  -32.176 -9.472  1.00 49.49 ?  266 VAL A O   1 
ATOM   2118 C CB  . VAL A 1 302 ? 14.950  -30.786 -9.365  1.00 39.86 ?  266 VAL A CB  1 
ATOM   2119 C CG1 . VAL A 1 302 ? 13.707  -30.458 -8.580  1.00 42.11 ?  266 VAL A CG1 1 
ATOM   2120 C CG2 . VAL A 1 302 ? 14.985  -30.008 -10.666 1.00 47.21 ?  266 VAL A CG2 1 
ATOM   2121 N N   . GLU A 1 303 ? 18.413  -30.068 -9.456  1.00 42.78 ?  267 GLU A N   1 
ATOM   2122 C CA  . GLU A 1 303 ? 19.738  -30.500 -9.883  1.00 46.96 ?  267 GLU A CA  1 
ATOM   2123 C C   . GLU A 1 303 ? 20.438  -31.314 -8.802  1.00 49.92 ?  267 GLU A C   1 
ATOM   2124 O O   . GLU A 1 303 ? 21.409  -32.018 -9.103  1.00 48.44 ?  267 GLU A O   1 
ATOM   2125 C CB  . GLU A 1 303 ? 20.595  -29.291 -10.279 1.00 42.32 ?  267 GLU A CB  1 
ATOM   2126 C CG  . GLU A 1 303 ? 21.113  -28.465 -9.111  1.00 40.10 ?  267 GLU A CG  1 
ATOM   2127 C CD  . GLU A 1 303 ? 20.109  -27.433 -8.645  1.00 40.65 ?  267 GLU A CD  1 
ATOM   2128 O OE1 . GLU A 1 303 ? 18.956  -27.512 -9.110  1.00 41.46 ?  267 GLU A OE1 1 
ATOM   2129 O OE2 . GLU A 1 303 ? 20.475  -26.543 -7.834  1.00 40.84 ?  267 GLU A OE2 1 
ATOM   2130 N N   . SER A 1 304 ? 19.957  -31.238 -7.557  1.00 50.18 ?  268 SER A N   1 
ATOM   2131 C CA  . SER A 1 304 ? 20.504  -31.991 -6.436  1.00 47.20 ?  268 SER A CA  1 
ATOM   2132 C C   . SER A 1 304 ? 19.697  -33.247 -6.112  1.00 46.46 ?  268 SER A C   1 
ATOM   2133 O O   . SER A 1 304 ? 19.919  -33.856 -5.061  1.00 44.21 ?  268 SER A O   1 
ATOM   2134 C CB  . SER A 1 304 ? 20.598  -31.094 -5.200  1.00 47.29 ?  268 SER A CB  1 
ATOM   2135 O OG  . SER A 1 304 ? 21.767  -30.283 -5.247  1.00 46.53 ?  268 SER A OG  1 
ATOM   2136 N N   . ASP A 1 305 ? 18.774  -33.649 -6.984  1.00 45.91 ?  269 ASP A N   1 
ATOM   2137 C CA  . ASP A 1 305 ? 18.030  -34.902 -6.811  1.00 47.18 ?  269 ASP A CA  1 
ATOM   2138 C C   . ASP A 1 305 ? 18.909  -36.120 -7.099  1.00 47.24 ?  269 ASP A C   1 
ATOM   2139 O O   . ASP A 1 305 ? 18.694  -37.200 -6.540  1.00 49.59 ?  269 ASP A O   1 
ATOM   2140 C CB  . ASP A 1 305 ? 16.794  -34.929 -7.723  1.00 49.20 ?  269 ASP A CB  1 
ATOM   2141 C CG  . ASP A 1 305 ? 15.742  -35.932 -7.265  1.00 49.76 ?  269 ASP A CG  1 
ATOM   2142 O OD1 . ASP A 1 305 ? 16.068  -37.137 -7.121  1.00 53.47 ?  269 ASP A OD1 1 
ATOM   2143 O OD2 . ASP A 1 305 ? 14.584  -35.511 -7.058  1.00 42.92 ?  269 ASP A OD2 1 
ATOM   2144 N N   . GLN A 1 321 ? 15.151  -32.177 -17.349 1.00 42.20 ?  285 GLN A N   1 
ATOM   2145 C CA  . GLN A 1 321 ? 15.265  -31.310 -16.173 1.00 47.11 ?  285 GLN A CA  1 
ATOM   2146 C C   . GLN A 1 321 ? 13.968  -30.517 -15.908 1.00 44.47 ?  285 GLN A C   1 
ATOM   2147 O O   . GLN A 1 321 ? 13.484  -30.528 -14.779 1.00 42.63 ?  285 GLN A O   1 
ATOM   2148 C CB  . GLN A 1 321 ? 16.465  -30.356 -16.301 1.00 47.88 ?  285 GLN A CB  1 
ATOM   2149 C CG  . GLN A 1 321 ? 17.837  -30.984 -15.961 1.00 52.83 ?  285 GLN A CG  1 
ATOM   2150 C CD  . GLN A 1 321 ? 18.032  -31.321 -14.476 1.00 56.11 ?  285 GLN A CD  1 
ATOM   2151 O OE1 . GLN A 1 321 ? 18.599  -30.526 -13.715 1.00 56.27 ?  285 GLN A OE1 1 
ATOM   2152 N NE2 . GLN A 1 321 ? 17.598  -32.516 -14.071 1.00 54.83 ?  285 GLN A NE2 1 
ATOM   2153 N N   . PRO A 1 322 ? 13.387  -29.842 -16.916 1.00 45.34 ?  286 PRO A N   1 
ATOM   2154 C CA  . PRO A 1 322 ? 12.021  -29.334 -16.706 1.00 46.90 ?  286 PRO A CA  1 
ATOM   2155 C C   . PRO A 1 322 ? 11.028  -30.462 -16.536 1.00 44.59 ?  286 PRO A C   1 
ATOM   2156 O O   . PRO A 1 322 ? 10.048  -30.315 -15.794 1.00 45.66 ?  286 PRO A O   1 
ATOM   2157 C CB  . PRO A 1 322 ? 11.728  -28.502 -17.967 1.00 42.25 ?  286 PRO A CB  1 
ATOM   2158 C CG  . PRO A 1 322 ? 13.024  -28.402 -18.707 1.00 43.15 ?  286 PRO A CG  1 
ATOM   2159 C CD  . PRO A 1 322 ? 13.850  -29.570 -18.290 1.00 45.28 ?  286 PRO A CD  1 
ATOM   2160 N N   . VAL A 1 323 ? 11.270  -31.589 -17.201 1.00 41.83 ?  287 VAL A N   1 
ATOM   2161 C CA  . VAL A 1 323 ? 10.439  -32.772 -17.012 1.00 39.32 ?  287 VAL A CA  1 
ATOM   2162 C C   . VAL A 1 323 ? 10.617  -33.325 -15.604 1.00 43.64 ?  287 VAL A C   1 
ATOM   2163 O O   . VAL A 1 323 ? 9.639   -33.602 -14.899 1.00 47.85 ?  287 VAL A O   1 
ATOM   2164 C CB  . VAL A 1 323 ? 10.776  -33.828 -18.078 1.00 44.71 ?  287 VAL A CB  1 
ATOM   2165 C CG1 . VAL A 1 323 ? 9.805   -34.987 -18.000 1.00 41.32 ?  287 VAL A CG1 1 
ATOM   2166 C CG2 . VAL A 1 323 ? 10.771  -33.188 -19.462 1.00 43.38 ?  287 VAL A CG2 1 
ATOM   2167 N N   . LEU A 1 324 ? 11.870  -33.488 -15.173 1.00 44.68 ?  288 LEU A N   1 
ATOM   2168 C CA  . LEU A 1 324 ? 12.129  -34.015 -13.838 1.00 45.85 ?  288 LEU A CA  1 
ATOM   2169 C C   . LEU A 1 324 ? 11.562  -33.089 -12.763 1.00 45.73 ?  288 LEU A C   1 
ATOM   2170 O O   . LEU A 1 324 ? 10.986  -33.554 -11.768 1.00 40.27 ?  288 LEU A O   1 
ATOM   2171 C CB  . LEU A 1 324 ? 13.634  -34.227 -13.657 1.00 43.62 ?  288 LEU A CB  1 
ATOM   2172 C CG  . LEU A 1 324 ? 14.133  -34.615 -12.265 1.00 46.56 ?  288 LEU A CG  1 
ATOM   2173 C CD1 . LEU A 1 324 ? 15.099  -35.782 -12.346 1.00 53.53 ?  288 LEU A CD1 1 
ATOM   2174 C CD2 . LEU A 1 324 ? 14.817  -33.446 -11.627 1.00 48.88 ?  288 LEU A CD2 1 
ATOM   2175 N N   . ALA A 1 325 ? 11.683  -31.772 -12.964 1.00 40.42 ?  289 ALA A N   1 
ATOM   2176 C CA  . ALA A 1 325 ? 11.202  -30.830 -11.960 1.00 39.13 ?  289 ALA A CA  1 
ATOM   2177 C C   . ALA A 1 325 ? 9.688   -30.906 -11.820 1.00 40.68 ?  289 ALA A C   1 
ATOM   2178 O O   . ALA A 1 325 ? 9.163   -31.015 -10.704 1.00 38.51 ?  289 ALA A O   1 
ATOM   2179 C CB  . ALA A 1 325 ? 11.647  -29.408 -12.305 1.00 38.42 ?  289 ALA A CB  1 
ATOM   2180 N N   . LYS A 1 326 ? 8.966   -30.857 -12.943 1.00 39.56 ?  290 LYS A N   1 
ATOM   2181 C CA  . LYS A 1 326 ? 7.512   -30.965 -12.870 1.00 44.33 ?  290 LYS A CA  1 
ATOM   2182 C C   . LYS A 1 326 ? 7.086   -32.313 -12.296 1.00 44.98 ?  290 LYS A C   1 
ATOM   2183 O O   . LYS A 1 326 ? 6.055   -32.406 -11.613 1.00 42.20 ?  290 LYS A O   1 
ATOM   2184 C CB  . LYS A 1 326 ? 6.901   -30.743 -14.254 1.00 45.10 ?  290 LYS A CB  1 
ATOM   2185 N N   . GLU A 1 327 ? 7.883   -33.358 -12.544 1.00 42.54 ?  291 GLU A N   1 
ATOM   2186 C CA  . GLU A 1 327 ? 7.613   -34.675 -11.972 1.00 45.63 ?  291 GLU A CA  1 
ATOM   2187 C C   . GLU A 1 327 ? 7.781   -34.654 -10.458 1.00 43.43 ?  291 GLU A C   1 
ATOM   2188 O O   . GLU A 1 327 ? 6.913   -35.131 -9.717  1.00 41.94 ?  291 GLU A O   1 
ATOM   2189 C CB  . GLU A 1 327 ? 8.559   -35.708 -12.593 1.00 48.05 ?  291 GLU A CB  1 
ATOM   2190 C CG  . GLU A 1 327 ? 7.899   -36.783 -13.447 1.00 53.17 ?  291 GLU A CG  1 
ATOM   2191 C CD  . GLU A 1 327 ? 8.926   -37.655 -14.177 1.00 58.85 ?  291 GLU A CD  1 
ATOM   2192 O OE1 . GLU A 1 327 ? 8.931   -37.660 -15.428 1.00 53.13 ?  291 GLU A OE1 1 
ATOM   2193 O OE2 . GLU A 1 327 ? 9.730   -38.336 -13.496 1.00 62.71 ?  291 GLU A OE2 1 
ATOM   2194 N N   . ARG A 1 328 ? 8.902   -34.108 -9.985  1.00 40.68 ?  292 ARG A N   1 
ATOM   2195 C CA  . ARG A 1 328 ? 9.248   -34.105 -8.571  1.00 42.58 ?  292 ARG A CA  1 
ATOM   2196 C C   . ARG A 1 328 ? 8.573   -32.992 -7.780  1.00 40.16 ?  292 ARG A C   1 
ATOM   2197 O O   . ARG A 1 328 ? 8.764   -32.933 -6.561  1.00 37.98 ?  292 ARG A O   1 
ATOM   2198 C CB  . ARG A 1 328 ? 10.768  -33.991 -8.406  1.00 42.07 ?  292 ARG A CB  1 
ATOM   2199 C CG  . ARG A 1 328 ? 11.523  -35.221 -8.860  1.00 41.09 ?  292 ARG A CG  1 
ATOM   2200 C CD  . ARG A 1 328 ? 11.073  -36.423 -8.072  1.00 39.59 ?  292 ARG A CD  1 
ATOM   2201 N NE  . ARG A 1 328 ? 11.909  -36.604 -6.893  1.00 40.66 ?  292 ARG A NE  1 
ATOM   2202 C CZ  . ARG A 1 328 ? 11.548  -37.294 -5.821  1.00 44.25 ?  292 ARG A CZ  1 
ATOM   2203 N NH1 . ARG A 1 328 ? 10.353  -37.855 -5.733  1.00 46.07 ?  292 ARG A NH1 1 
ATOM   2204 N NH2 . ARG A 1 328 ? 12.414  -37.440 -4.819  1.00 45.13 ?  292 ARG A NH2 1 
ATOM   2205 N N   . ALA A 1 329 ? 7.780   -32.128 -8.425  1.00 40.32 ?  293 ALA A N   1 
ATOM   2206 C CA  . ALA A 1 329 ? 7.249   -30.962 -7.722  1.00 38.28 ?  293 ALA A CA  1 
ATOM   2207 C C   . ALA A 1 329 ? 6.310   -31.359 -6.587  1.00 43.36 ?  293 ALA A C   1 
ATOM   2208 O O   . ALA A 1 329 ? 6.260   -30.672 -5.559  1.00 33.11 ?  293 ALA A O   1 
ATOM   2209 C CB  . ALA A 1 329 ? 6.535   -30.032 -8.697  1.00 38.84 ?  293 ALA A CB  1 
ATOM   2210 N N   . GLU A 1 330 ? 5.563   -32.461 -6.745  1.00 38.49 ?  294 GLU A N   1 
ATOM   2211 C CA  . GLU A 1 330 ? 4.702   -32.909 -5.655  1.00 38.38 ?  294 GLU A CA  1 
ATOM   2212 C C   . GLU A 1 330 ? 5.514   -33.361 -4.450  1.00 37.10 ?  294 GLU A C   1 
ATOM   2213 O O   . GLU A 1 330 ? 5.083   -33.162 -3.309  1.00 37.17 ?  294 GLU A O   1 
ATOM   2214 C CB  . GLU A 1 330 ? 3.786   -34.045 -6.103  1.00 37.26 ?  294 GLU A CB  1 
ATOM   2215 C CG  . GLU A 1 330 ? 2.925   -34.589 -4.971  1.00 36.84 ?  294 GLU A CG  1 
ATOM   2216 C CD  . GLU A 1 330 ? 1.864   -35.532 -5.466  1.00 37.33 ?  294 GLU A CD  1 
ATOM   2217 O OE1 . GLU A 1 330 ? 2.213   -36.414 -6.268  1.00 43.55 ?  294 GLU A OE1 1 
ATOM   2218 O OE2 . GLU A 1 330 ? 0.687   -35.392 -5.066  1.00 40.13 ?  294 GLU A OE2 1 
ATOM   2219 N N   . TYR A 1 331 ? 6.692   -33.947 -4.671  1.00 32.31 ?  295 TYR A N   1 
ATOM   2220 C CA  . TYR A 1 331 ? 7.459   -34.441 -3.535  1.00 32.13 ?  295 TYR A CA  1 
ATOM   2221 C C   . TYR A 1 331 ? 8.125   -33.310 -2.771  1.00 32.89 ?  295 TYR A C   1 
ATOM   2222 O O   . TYR A 1 331 ? 8.129   -33.315 -1.533  1.00 33.13 ?  295 TYR A O   1 
ATOM   2223 C CB  . TYR A 1 331 ? 8.525   -35.441 -3.982  1.00 33.67 ?  295 TYR A CB  1 
ATOM   2224 C CG  . TYR A 1 331 ? 9.504   -35.779 -2.873  1.00 32.81 ?  295 TYR A CG  1 
ATOM   2225 C CD1 . TYR A 1 331 ? 9.170   -36.697 -1.883  1.00 35.68 ?  295 TYR A CD1 1 
ATOM   2226 C CD2 . TYR A 1 331 ? 10.756  -35.165 -2.800  1.00 34.00 ?  295 TYR A CD2 1 
ATOM   2227 C CE1 . TYR A 1 331 ? 10.050  -37.005 -0.855  1.00 32.61 ?  295 TYR A CE1 1 
ATOM   2228 C CE2 . TYR A 1 331 ? 11.653  -35.471 -1.767  1.00 33.32 ?  295 TYR A CE2 1 
ATOM   2229 C CZ  . TYR A 1 331 ? 11.290  -36.394 -0.800  1.00 34.37 ?  295 TYR A CZ  1 
ATOM   2230 O OH  . TYR A 1 331 ? 12.157  -36.712 0.232   1.00 33.25 ?  295 TYR A OH  1 
ATOM   2231 N N   . TYR A 1 332 ? 8.729   -32.359 -3.488  1.00 33.46 ?  296 TYR A N   1 
ATOM   2232 C CA  . TYR A 1 332 ? 9.488   -31.304 -2.823  1.00 32.09 ?  296 TYR A CA  1 
ATOM   2233 C C   . TYR A 1 332 ? 8.586   -30.226 -2.248  1.00 28.17 ?  296 TYR A C   1 
ATOM   2234 O O   . TYR A 1 332 ? 8.945   -29.605 -1.245  1.00 34.28 ?  296 TYR A O   1 
ATOM   2235 C CB  . TYR A 1 332 ? 10.497  -30.685 -3.789  1.00 32.06 ?  296 TYR A CB  1 
ATOM   2236 C CG  . TYR A 1 332 ? 11.688  -31.569 -4.039  1.00 30.69 ?  296 TYR A CG  1 
ATOM   2237 C CD1 . TYR A 1 332 ? 12.453  -32.038 -2.986  1.00 31.50 ?  296 TYR A CD1 1 
ATOM   2238 C CD2 . TYR A 1 332 ? 12.036  -31.951 -5.330  1.00 32.99 ?  296 TYR A CD2 1 
ATOM   2239 C CE1 . TYR A 1 332 ? 13.541  -32.856 -3.198  1.00 32.17 ?  296 TYR A CE1 1 
ATOM   2240 C CE2 . TYR A 1 332 ? 13.123  -32.771 -5.559  1.00 36.47 ?  296 TYR A CE2 1 
ATOM   2241 C CZ  . TYR A 1 332 ? 13.872  -33.223 -4.488  1.00 36.00 ?  296 TYR A CZ  1 
ATOM   2242 O OH  . TYR A 1 332 ? 14.958  -34.034 -4.700  1.00 39.51 ?  296 TYR A OH  1 
ATOM   2243 N N   . LEU A 1 333 ? 7.436   -29.970 -2.877  1.00 30.46 ?  297 LEU A N   1 
ATOM   2244 C CA  . LEU A 1 333 ? 6.425   -29.132 -2.246  1.00 29.28 ?  297 LEU A CA  1 
ATOM   2245 C C   . LEU A 1 333 ? 5.999   -29.726 -0.911  1.00 30.56 ?  297 LEU A C   1 
ATOM   2246 O O   . LEU A 1 333 ? 5.968   -29.030 0.109   1.00 27.22 ?  297 LEU A O   1 
ATOM   2247 C CB  . LEU A 1 333 ? 5.211   -28.965 -3.169  1.00 30.69 ?  297 LEU A CB  1 
ATOM   2248 C CG  . LEU A 1 333 ? 4.074   -28.100 -2.604  1.00 27.59 ?  297 LEU A CG  1 
ATOM   2249 C CD1 . LEU A 1 333 ? 4.632   -26.742 -2.184  1.00 25.35 ?  297 LEU A CD1 1 
ATOM   2250 C CD2 . LEU A 1 333 ? 2.894   -27.943 -3.580  1.00 25.70 ?  297 LEU A CD2 1 
ATOM   2251 N N   . ALA A 1 334 ? 5.659   -31.021 -0.902  1.00 28.91 ?  298 ALA A N   1 
ATOM   2252 C CA  . ALA A 1 334 ? 5.241   -31.674 0.336   1.00 27.33 ?  298 ALA A CA  1 
ATOM   2253 C C   . ALA A 1 334 ? 6.324   -31.578 1.401   1.00 26.17 ?  298 ALA A C   1 
ATOM   2254 O O   . ALA A 1 334 ? 6.026   -31.406 2.589   1.00 24.18 ?  298 ALA A O   1 
ATOM   2255 C CB  . ALA A 1 334 ? 4.894   -33.138 0.066   1.00 24.81 ?  298 ALA A CB  1 
ATOM   2256 N N   . CYS A 1 335 ? 7.588   -31.704 1.000   1.00 26.16 ?  299 CYS A N   1 
ATOM   2257 C CA  . CYS A 1 335 ? 8.671   -31.533 1.959   1.00 25.84 ?  299 CYS A CA  1 
ATOM   2258 C C   . CYS A 1 335 ? 8.630   -30.154 2.590   1.00 27.43 ?  299 CYS A C   1 
ATOM   2259 O O   . CYS A 1 335 ? 8.907   -30.004 3.786   1.00 28.43 ?  299 CYS A O   1 
ATOM   2260 C CB  . CYS A 1 335 ? 10.013  -31.770 1.285   1.00 34.89 ?  299 CYS A CB  1 
ATOM   2261 S SG  . CYS A 1 335 ? 10.365  -33.512 1.064   1.00 29.38 ?  299 CYS A SG  1 
ATOM   2262 N N   . TYR A 1 336 ? 8.289   -29.133 1.803   1.00 26.36 ?  300 TYR A N   1 
ATOM   2263 C CA  . TYR A 1 336 ? 8.157   -27.795 2.365   1.00 29.30 ?  300 TYR A CA  1 
ATOM   2264 C C   . TYR A 1 336 ? 6.907   -27.697 3.230   1.00 26.30 ?  300 TYR A C   1 
ATOM   2265 O O   . TYR A 1 336 ? 6.960   -27.177 4.351   1.00 24.25 ?  300 TYR A O   1 
ATOM   2266 C CB  . TYR A 1 336 ? 8.121   -26.743 1.246   1.00 28.37 ?  300 TYR A CB  1 
ATOM   2267 C CG  . TYR A 1 336 ? 7.493   -25.422 1.665   1.00 25.14 ?  300 TYR A CG  1 
ATOM   2268 C CD1 . TYR A 1 336 ? 8.122   -24.590 2.580   1.00 25.71 ?  300 TYR A CD1 1 
ATOM   2269 C CD2 . TYR A 1 336 ? 6.264   -25.035 1.168   1.00 26.06 ?  300 TYR A CD2 1 
ATOM   2270 C CE1 . TYR A 1 336 ? 7.544   -23.393 2.979   1.00 26.27 ?  300 TYR A CE1 1 
ATOM   2271 C CE2 . TYR A 1 336 ? 5.665   -23.853 1.568   1.00 26.24 ?  300 TYR A CE2 1 
ATOM   2272 C CZ  . TYR A 1 336 ? 6.313   -23.030 2.470   1.00 28.27 ?  300 TYR A CZ  1 
ATOM   2273 O OH  . TYR A 1 336 ? 5.728   -21.846 2.860   1.00 24.07 ?  300 TYR A OH  1 
ATOM   2274 N N   . LEU A 1 337 ? 5.783   -28.223 2.739   1.00 22.67 ?  301 LEU A N   1 
ATOM   2275 C CA  . LEU A 1 337 ? 4.515   -27.998 3.425   1.00 25.13 ?  301 LEU A CA  1 
ATOM   2276 C C   . LEU A 1 337 ? 4.488   -28.657 4.792   1.00 24.18 ?  301 LEU A C   1 
ATOM   2277 O O   . LEU A 1 337 ? 3.781   -28.185 5.684   1.00 24.03 ?  301 LEU A O   1 
ATOM   2278 C CB  . LEU A 1 337 ? 3.355   -28.491 2.566   1.00 26.77 ?  301 LEU A CB  1 
ATOM   2279 C CG  . LEU A 1 337 ? 3.063   -27.723 1.268   1.00 28.20 ?  301 LEU A CG  1 
ATOM   2280 C CD1 . LEU A 1 337 ? 2.004   -28.465 0.480   1.00 25.38 ?  301 LEU A CD1 1 
ATOM   2281 C CD2 . LEU A 1 337 ? 2.609   -26.292 1.574   1.00 21.50 ?  301 LEU A CD2 1 
ATOM   2282 N N   . ILE A 1 338 ? 5.263   -29.725 4.991   1.00 25.19 ?  302 ILE A N   1 
ATOM   2283 C CA  . ILE A 1 338 ? 5.326   -30.347 6.313   1.00 24.07 ?  302 ILE A CA  1 
ATOM   2284 C C   . ILE A 1 338 ? 5.826   -29.347 7.349   1.00 22.31 ?  302 ILE A C   1 
ATOM   2285 O O   . ILE A 1 338 ? 5.325   -29.295 8.477   1.00 22.40 ?  302 ILE A O   1 
ATOM   2286 C CB  . ILE A 1 338 ? 6.214   -31.610 6.265   1.00 24.68 ?  302 ILE A CB  1 
ATOM   2287 C CG1 . ILE A 1 338 ? 5.513   -32.744 5.510   1.00 26.86 ?  302 ILE A CG1 1 
ATOM   2288 C CG2 . ILE A 1 338 ? 6.602   -32.055 7.656   1.00 23.82 ?  302 ILE A CG2 1 
ATOM   2289 C CD1 . ILE A 1 338 ? 4.247   -33.301 6.219   1.00 22.84 ?  302 ILE A CD1 1 
ATOM   2290 N N   . GLY A 1 339 ? 6.794   -28.515 6.978   1.00 25.97 ?  303 GLY A N   1 
ATOM   2291 C CA  . GLY A 1 339 ? 7.413   -27.616 7.938   1.00 26.53 ?  303 GLY A CA  1 
ATOM   2292 C C   . GLY A 1 339 ? 7.033   -26.154 7.797   1.00 22.96 ?  303 GLY A C   1 
ATOM   2293 O O   . GLY A 1 339 ? 7.488   -25.321 8.583   1.00 22.47 ?  303 GLY A O   1 
ATOM   2294 N N   . ALA A 1 340 ? 6.179   -25.852 6.819   1.00 23.80 ?  304 ALA A N   1 
ATOM   2295 C CA  . ALA A 1 340 ? 5.809   -24.478 6.479   1.00 23.52 ?  304 ALA A CA  1 
ATOM   2296 C C   . ALA A 1 340 ? 5.282   -23.690 7.679   1.00 22.05 ?  304 ALA A C   1 
ATOM   2297 O O   . ALA A 1 340 ? 4.537   -24.204 8.520   1.00 20.99 ?  304 ALA A O   1 
ATOM   2298 C CB  . ALA A 1 340 ? 4.754   -24.492 5.372   1.00 23.12 ?  304 ALA A CB  1 
ATOM   2299 N N   . GLN A 1 341 ? 5.661   -22.424 7.739   1.00 23.60 ?  305 GLN A N   1 
ATOM   2300 C CA  . GLN A 1 341 ? 5.341   -21.517 8.827   1.00 21.53 ?  305 GLN A CA  1 
ATOM   2301 C C   . GLN A 1 341 ? 4.860   -20.219 8.209   1.00 23.66 ?  305 GLN A C   1 
ATOM   2302 O O   . GLN A 1 341 ? 5.083   -19.981 7.021   1.00 22.89 ?  305 GLN A O   1 
ATOM   2303 C CB  . GLN A 1 341 ? 6.565   -21.253 9.721   1.00 22.36 ?  305 GLN A CB  1 
ATOM   2304 C CG  . GLN A 1 341 ? 7.178   -22.487 10.399  1.00 20.39 ?  305 GLN A CG  1 
ATOM   2305 C CD  . GLN A 1 341 ? 6.286   -23.078 11.504  1.00 27.33 ?  305 GLN A CD  1 
ATOM   2306 O OE1 . GLN A 1 341 ? 5.244   -22.512 11.861  1.00 24.65 ?  305 GLN A OE1 1 
ATOM   2307 N NE2 . GLN A 1 341 ? 6.703   -24.221 12.049  1.00 21.70 ?  305 GLN A NE2 1 
ATOM   2308 N N   . PRO A 1 342 ? 4.169   -19.371 8.973   1.00 19.20 ?  306 PRO A N   1 
ATOM   2309 C CA  . PRO A 1 342 ? 3.871   -18.033 8.474   1.00 21.51 ?  306 PRO A CA  1 
ATOM   2310 C C   . PRO A 1 342 ? 5.138   -17.386 7.949   1.00 22.66 ?  306 PRO A C   1 
ATOM   2311 O O   . PRO A 1 342 ? 6.222   -17.581 8.491   1.00 19.86 ?  306 PRO A O   1 
ATOM   2312 C CB  . PRO A 1 342 ? 3.334   -17.306 9.708   1.00 24.68 ?  306 PRO A CB  1 
ATOM   2313 C CG  . PRO A 1 342 ? 2.788   -18.375 10.580  1.00 26.83 ?  306 PRO A CG  1 
ATOM   2314 C CD  . PRO A 1 342 ? 3.463   -19.668 10.230  1.00 23.26 ?  306 PRO A CD  1 
ATOM   2315 N N   . TYR A 1 343 ? 4.999   -16.657 6.851   1.00 24.86 ?  307 TYR A N   1 
ATOM   2316 C CA  . TYR A 1 343 ? 6.098   -15.887 6.281   1.00 23.84 ?  307 TYR A CA  1 
ATOM   2317 C C   . TYR A 1 343 ? 7.300   -16.770 5.965   1.00 26.40 ?  307 TYR A C   1 
ATOM   2318 O O   . TYR A 1 343 ? 8.448   -16.326 6.015   1.00 22.98 ?  307 TYR A O   1 
ATOM   2319 C CB  . TYR A 1 343 ? 6.474   -14.716 7.195   1.00 23.44 ?  307 TYR A CB  1 
ATOM   2320 C CG  . TYR A 1 343 ? 5.402   -13.661 7.162   1.00 20.74 ?  307 TYR A CG  1 
ATOM   2321 C CD1 . TYR A 1 343 ? 4.305   -13.737 8.001   1.00 24.38 ?  307 TYR A CD1 1 
ATOM   2322 C CD2 . TYR A 1 343 ? 5.435   -12.643 6.227   1.00 25.83 ?  307 TYR A CD2 1 
ATOM   2323 C CE1 . TYR A 1 343 ? 3.291   -12.785 7.956   1.00 24.32 ?  307 TYR A CE1 1 
ATOM   2324 C CE2 . TYR A 1 343 ? 4.428   -11.694 6.166   1.00 27.60 ?  307 TYR A CE2 1 
ATOM   2325 C CZ  . TYR A 1 343 ? 3.360   -11.776 7.036   1.00 26.58 ?  307 TYR A CZ  1 
ATOM   2326 O OH  . TYR A 1 343 ? 2.359   -10.842 6.980   1.00 30.44 ?  307 TYR A OH  1 
ATOM   2327 N N   . SER A 1 344 ? 7.043   -18.034 5.651   1.00 22.64 ?  308 SER A N   1 
ATOM   2328 C CA  . SER A 1 344 ? 8.024   -18.868 4.977   1.00 24.90 ?  308 SER A CA  1 
ATOM   2329 C C   . SER A 1 344 ? 7.576   -19.047 3.531   1.00 25.13 ?  308 SER A C   1 
ATOM   2330 O O   . SER A 1 344 ? 6.384   -18.986 3.222   1.00 21.78 ?  308 SER A O   1 
ATOM   2331 C CB  . SER A 1 344 ? 8.189   -20.224 5.657   1.00 20.60 ?  308 SER A CB  1 
ATOM   2332 O OG  . SER A 1 344 ? 7.077   -21.054 5.373   1.00 24.51 ?  308 SER A OG  1 
ATOM   2333 N N   . TYR A 1 345 ? 8.545   -19.244 2.648   1.00 26.25 ?  309 TYR A N   1 
ATOM   2334 C CA  . TYR A 1 345 ? 8.298   -19.222 1.215   1.00 24.91 ?  309 TYR A CA  1 
ATOM   2335 C C   . TYR A 1 345 ? 9.026   -20.388 0.560   1.00 28.15 ?  309 TYR A C   1 
ATOM   2336 O O   . TYR A 1 345 ? 10.114  -20.781 0.992   1.00 23.77 ?  309 TYR A O   1 
ATOM   2337 C CB  . TYR A 1 345 ? 8.762   -17.899 0.587   1.00 22.44 ?  309 TYR A CB  1 
ATOM   2338 C CG  . TYR A 1 345 ? 8.066   -16.704 1.186   1.00 22.51 ?  309 TYR A CG  1 
ATOM   2339 C CD1 . TYR A 1 345 ? 8.517   -16.137 2.367   1.00 23.14 ?  309 TYR A CD1 1 
ATOM   2340 C CD2 . TYR A 1 345 ? 6.932   -16.169 0.587   1.00 21.31 ?  309 TYR A CD2 1 
ATOM   2341 C CE1 . TYR A 1 345 ? 7.865   -15.053 2.937   1.00 22.50 ?  309 TYR A CE1 1 
ATOM   2342 C CE2 . TYR A 1 345 ? 6.272   -15.095 1.143   1.00 21.37 ?  309 TYR A CE2 1 
ATOM   2343 C CZ  . TYR A 1 345 ? 6.745   -14.538 2.311   1.00 22.81 ?  309 TYR A CZ  1 
ATOM   2344 O OH  . TYR A 1 345 ? 6.085   -13.467 2.857   1.00 23.64 ?  309 TYR A OH  1 
ATOM   2345 N N   . PHE A 1 346 ? 8.404   -20.937 -0.484  1.00 27.01 ?  310 PHE A N   1 
ATOM   2346 C CA  . PHE A 1 346 ? 8.963   -22.024 -1.275  1.00 25.81 ?  310 PHE A CA  1 
ATOM   2347 C C   . PHE A 1 346 ? 9.645   -21.442 -2.507  1.00 25.60 ?  310 PHE A C   1 
ATOM   2348 O O   . PHE A 1 346 ? 9.105   -20.545 -3.160  1.00 21.33 ?  310 PHE A O   1 
ATOM   2349 C CB  . PHE A 1 346 ? 7.854   -23.002 -1.693  1.00 26.97 ?  310 PHE A CB  1 
ATOM   2350 C CG  . PHE A 1 346 ? 8.353   -24.322 -2.266  1.00 30.18 ?  310 PHE A CG  1 
ATOM   2351 C CD1 . PHE A 1 346 ? 9.226   -25.130 -1.552  1.00 27.63 ?  310 PHE A CD1 1 
ATOM   2352 C CD2 . PHE A 1 346 ? 7.930   -24.753 -3.513  1.00 28.08 ?  310 PHE A CD2 1 
ATOM   2353 C CE1 . PHE A 1 346 ? 9.666   -26.343 -2.070  1.00 26.65 ?  310 PHE A CE1 1 
ATOM   2354 C CE2 . PHE A 1 346 ? 8.377   -25.966 -4.035  1.00 26.14 ?  310 PHE A CE2 1 
ATOM   2355 C CZ  . PHE A 1 346 ? 9.242   -26.754 -3.315  1.00 24.58 ?  310 PHE A CZ  1 
ATOM   2356 N N   . GLN A 1 347 ? 10.835  -21.944 -2.819  1.00 26.32 ?  311 GLN A N   1 
ATOM   2357 C CA  . GLN A 1 347 ? 11.486  -21.653 -4.092  1.00 28.93 ?  311 GLN A CA  1 
ATOM   2358 C C   . GLN A 1 347 ? 11.720  -22.966 -4.824  1.00 29.33 ?  311 GLN A C   1 
ATOM   2359 O O   . GLN A 1 347 ? 12.186  -23.937 -4.217  1.00 28.01 ?  311 GLN A O   1 
ATOM   2360 C CB  . GLN A 1 347 ? 12.811  -20.911 -3.905  1.00 24.50 ?  311 GLN A CB  1 
ATOM   2361 C CG  . GLN A 1 347 ? 13.395  -20.435 -5.246  1.00 28.30 ?  311 GLN A CG  1 
ATOM   2362 C CD  . GLN A 1 347 ? 14.848  -19.962 -5.155  1.00 27.29 ?  311 GLN A CD  1 
ATOM   2363 O OE1 . GLN A 1 347 ? 15.299  -19.470 -4.115  1.00 23.09 ?  311 GLN A OE1 1 
ATOM   2364 N NE2 . GLN A 1 347 ? 15.583  -20.099 -6.264  1.00 29.33 ?  311 GLN A NE2 1 
ATOM   2365 N N   . TYR A 1 348 ? 11.399  -22.999 -6.123  1.00 28.09 ?  312 TYR A N   1 
ATOM   2366 C CA  . TYR A 1 348 ? 11.474  -24.245 -6.878  1.00 30.17 ?  312 TYR A CA  1 
ATOM   2367 C C   . TYR A 1 348 ? 12.013  -24.031 -8.284  1.00 30.69 ?  312 TYR A C   1 
ATOM   2368 O O   . TYR A 1 348 ? 11.640  -23.080 -8.974  1.00 28.37 ?  312 TYR A O   1 
ATOM   2369 C CB  . TYR A 1 348 ? 10.106  -24.923 -6.981  1.00 26.83 ?  312 TYR A CB  1 
ATOM   2370 C CG  . TYR A 1 348 ? 10.186  -26.380 -7.372  1.00 33.03 ?  312 TYR A CG  1 
ATOM   2371 C CD1 . TYR A 1 348 ? 10.853  -27.300 -6.567  1.00 31.62 ?  312 TYR A CD1 1 
ATOM   2372 C CD2 . TYR A 1 348 ? 9.600   -26.840 -8.545  1.00 36.40 ?  312 TYR A CD2 1 
ATOM   2373 C CE1 . TYR A 1 348 ? 10.939  -28.644 -6.920  1.00 32.83 ?  312 TYR A CE1 1 
ATOM   2374 C CE2 . TYR A 1 348 ? 9.679   -28.191 -8.908  1.00 37.41 ?  312 TYR A CE2 1 
ATOM   2375 C CZ  . TYR A 1 348 ? 10.352  -29.082 -8.086  1.00 38.05 ?  312 TYR A CZ  1 
ATOM   2376 O OH  . TYR A 1 348 ? 10.435  -30.417 -8.417  1.00 40.43 ?  312 TYR A OH  1 
ATOM   2377 N N   . GLY A 1 349 ? 12.861  -24.959 -8.707  1.00 31.92 ?  313 GLY A N   1 
ATOM   2378 C CA  . GLY A 1 349 ? 13.399  -24.965 -10.060 1.00 31.05 ?  313 GLY A CA  1 
ATOM   2379 C C   . GLY A 1 349 ? 14.508  -25.990 -10.155 1.00 38.43 ?  313 GLY A C   1 
ATOM   2380 O O   . GLY A 1 349 ? 14.519  -26.988 -9.417  1.00 36.91 ?  313 GLY A O   1 
ATOM   2381 N N   . TRP A 1 350 ? 15.457  -25.724 -11.060 1.00 36.67 ?  314 TRP A N   1 
ATOM   2382 C CA  . TRP A 1 350 ? 16.657  -26.546 -11.168 1.00 38.71 ?  314 TRP A CA  1 
ATOM   2383 C C   . TRP A 1 350 ? 17.923  -25.698 -11.214 1.00 42.13 ?  314 TRP A C   1 
ATOM   2384 O O   . TRP A 1 350 ? 18.964  -26.177 -11.679 1.00 37.69 ?  314 TRP A O   1 
ATOM   2385 C CB  . TRP A 1 350 ? 16.602  -27.462 -12.394 1.00 42.68 ?  314 TRP A CB  1 
ATOM   2386 C CG  . TRP A 1 350 ? 16.200  -26.776 -13.653 1.00 37.67 ?  314 TRP A CG  1 
ATOM   2387 C CD1 . TRP A 1 350 ? 17.026  -26.235 -14.590 1.00 40.21 ?  314 TRP A CD1 1 
ATOM   2388 C CD2 . TRP A 1 350 ? 14.865  -26.559 -14.119 1.00 39.54 ?  314 TRP A CD2 1 
ATOM   2389 N NE1 . TRP A 1 350 ? 16.287  -25.687 -15.614 1.00 35.39 ?  314 TRP A NE1 1 
ATOM   2390 C CE2 . TRP A 1 350 ? 14.958  -25.877 -15.351 1.00 36.60 ?  314 TRP A CE2 1 
ATOM   2391 C CE3 . TRP A 1 350 ? 13.598  -26.864 -13.608 1.00 36.45 ?  314 TRP A CE3 1 
ATOM   2392 C CZ2 . TRP A 1 350 ? 13.832  -25.502 -16.086 1.00 36.36 ?  314 TRP A CZ2 1 
ATOM   2393 C CZ3 . TRP A 1 350 ? 12.485  -26.497 -14.338 1.00 41.78 ?  314 TRP A CZ3 1 
ATOM   2394 C CH2 . TRP A 1 350 ? 12.608  -25.818 -15.565 1.00 40.53 ?  314 TRP A CH2 1 
ATOM   2395 N N   . GLY A 1 351 ? 17.860  -24.459 -10.736 1.00 37.18 ?  315 GLY A N   1 
ATOM   2396 C CA  . GLY A 1 351 ? 19.049  -23.632 -10.674 1.00 38.25 ?  315 GLY A CA  1 
ATOM   2397 C C   . GLY A 1 351 ? 18.687  -22.192 -10.353 1.00 40.31 ?  315 GLY A C   1 
ATOM   2398 O O   . GLY A 1 351 ? 17.611  -21.910 -9.807  1.00 32.76 ?  315 GLY A O   1 
ATOM   2399 N N   . TRP A 1 352 ? 19.610  -21.283 -10.697 1.00 34.57 ?  316 TRP A N   1 
ATOM   2400 C CA  . TRP A 1 352 ? 19.477  -19.850 -10.332 1.00 33.70 ?  316 TRP A CA  1 
ATOM   2401 C C   . TRP A 1 352 ? 19.495  -18.943 -11.571 1.00 32.03 ?  316 TRP A C   1 
ATOM   2402 O O   . TRP A 1 352 ? 19.590  -17.724 -11.405 1.00 29.39 ?  316 TRP A O   1 
ATOM   2403 C CB  . TRP A 1 352 ? 20.610  -19.496 -9.367  1.00 35.70 ?  316 TRP A CB  1 
ATOM   2404 C CG  . TRP A 1 352 ? 20.715  -20.407 -8.186  1.00 35.18 ?  316 TRP A CG  1 
ATOM   2405 C CD1 . TRP A 1 352 ? 21.499  -21.516 -8.063  1.00 39.83 ?  316 TRP A CD1 1 
ATOM   2406 C CD2 . TRP A 1 352 ? 19.999  -20.284 -6.947  1.00 32.27 ?  316 TRP A CD2 1 
ATOM   2407 N NE1 . TRP A 1 352 ? 21.323  -22.088 -6.834  1.00 34.49 ?  316 TRP A NE1 1 
ATOM   2408 C CE2 . TRP A 1 352 ? 20.407  -21.357 -6.129  1.00 31.31 ?  316 TRP A CE2 1 
ATOM   2409 C CE3 . TRP A 1 352 ? 19.061  -19.375 -6.452  1.00 32.42 ?  316 TRP A CE3 1 
ATOM   2410 C CZ2 . TRP A 1 352 ? 19.909  -21.538 -4.843  1.00 32.13 ?  316 TRP A CZ2 1 
ATOM   2411 C CZ3 . TRP A 1 352 ? 18.563  -19.561 -5.183  1.00 34.74 ?  316 TRP A CZ3 1 
ATOM   2412 C CH2 . TRP A 1 352 ? 18.984  -20.627 -4.391  1.00 30.64 ?  316 TRP A CH2 1 
ATOM   2413 N N   . THR A 1 353 ? 19.404  -19.519 -12.764 1.00 30.93 ?  317 THR A N   1 
ATOM   2414 C CA  . THR A 1 353 ? 19.301  -18.689 -13.984 1.00 32.97 ?  317 THR A CA  1 
ATOM   2415 C C   . THR A 1 353 ? 17.829  -18.367 -14.241 1.00 32.83 ?  317 THR A C   1 
ATOM   2416 O O   . THR A 1 353 ? 16.969  -19.033 -13.674 1.00 31.95 ?  317 THR A O   1 
ATOM   2417 C CB  . THR A 1 353 ? 19.920  -19.379 -15.211 1.00 32.65 ?  317 THR A CB  1 
ATOM   2418 O OG1 . THR A 1 353 ? 19.017  -20.365 -15.708 1.00 33.28 ?  317 THR A OG1 1 
ATOM   2419 C CG2 . THR A 1 353 ? 21.265  -20.005 -14.916 1.00 32.35 ?  317 THR A CG2 1 
ATOM   2420 N N   . LEU A 1 354 ? 17.571  -17.398 -15.107 1.00 35.96 ?  318 LEU A N   1 
ATOM   2421 C CA  . LEU A 1 354 ? 16.194  -17.124 -15.502 1.00 36.47 ?  318 LEU A CA  1 
ATOM   2422 C C   . LEU A 1 354 ? 15.561  -18.356 -16.130 1.00 34.62 ?  318 LEU A C   1 
ATOM   2423 O O   . LEU A 1 354 ? 14.372  -18.633 -15.923 1.00 34.11 ?  318 LEU A O   1 
ATOM   2424 C CB  . LEU A 1 354 ? 16.161  -15.939 -16.466 1.00 31.60 ?  318 LEU A CB  1 
ATOM   2425 C CG  . LEU A 1 354 ? 14.799  -15.544 -17.011 1.00 35.50 ?  318 LEU A CG  1 
ATOM   2426 C CD1 . LEU A 1 354 ? 13.807  -15.354 -15.876 1.00 25.90 ?  318 LEU A CD1 1 
ATOM   2427 C CD2 . LEU A 1 354 ? 14.973  -14.266 -17.824 1.00 33.79 ?  318 LEU A CD2 1 
ATOM   2428 N N   . SER A 1 355 ? 16.355  -19.128 -16.867 1.00 36.79 ?  319 SER A N   1 
ATOM   2429 C CA  . SER A 1 355 ? 15.892  -20.328 -17.547 1.00 35.92 ?  319 SER A CA  1 
ATOM   2430 C C   . SER A 1 355 ? 15.782  -21.532 -16.613 1.00 34.51 ?  319 SER A C   1 
ATOM   2431 O O   . SER A 1 355 ? 15.497  -22.637 -17.088 1.00 30.04 ?  319 SER A O   1 
ATOM   2432 C CB  . SER A 1 355 ? 16.826  -20.646 -18.724 1.00 37.58 ?  319 SER A CB  1 
ATOM   2433 O OG  . SER A 1 355 ? 18.069  -21.177 -18.268 1.00 40.07 ?  319 SER A OG  1 
ATOM   2434 N N   . SER A 1 356 ? 15.975  -21.339 -15.303 1.00 32.63 ?  320 SER A N   1 
ATOM   2435 C CA  . SER A 1 356 ? 16.077  -22.440 -14.352 1.00 34.46 ?  320 SER A CA  1 
ATOM   2436 C C   . SER A 1 356 ? 14.765  -22.729 -13.622 1.00 33.73 ?  320 SER A C   1 
ATOM   2437 O O   . SER A 1 356 ? 14.785  -23.340 -12.549 1.00 33.24 ?  320 SER A O   1 
ATOM   2438 C CB  . SER A 1 356 ? 17.184  -22.165 -13.329 1.00 33.52 ?  320 SER A CB  1 
ATOM   2439 O OG  . SER A 1 356 ? 18.466  -22.037 -13.926 1.00 33.34 ?  320 SER A OG  1 
ATOM   2440 N N   . GLY A 1 357 ? 13.630  -22.312 -14.168 1.00 36.19 ?  321 GLY A N   1 
ATOM   2441 C CA  . GLY A 1 357 ? 12.371  -22.680 -13.554 1.00 32.33 ?  321 GLY A CA  1 
ATOM   2442 C C   . GLY A 1 357 ? 11.413  -21.536 -13.285 1.00 34.40 ?  321 GLY A C   1 
ATOM   2443 O O   . GLY A 1 357 ? 10.194  -21.746 -13.266 1.00 31.77 ?  321 GLY A O   1 
ATOM   2444 N N   . SER A 1 358 ? 11.945  -20.321 -13.083 1.00 30.14 ?  322 SER A N   1 
ATOM   2445 C CA  . SER A 1 358 ? 11.086  -19.198 -12.726 1.00 31.52 ?  322 SER A CA  1 
ATOM   2446 C C   . SER A 1 358 ? 10.013  -18.964 -13.778 1.00 31.78 ?  322 SER A C   1 
ATOM   2447 O O   . SER A 1 358 ? 8.922   -18.490 -13.450 1.00 32.26 ?  322 SER A O   1 
ATOM   2448 C CB  . SER A 1 358 ? 11.921  -17.929 -12.509 1.00 30.96 ?  322 SER A CB  1 
ATOM   2449 O OG  . SER A 1 358 ? 12.892  -18.140 -11.489 1.00 25.71 ?  322 SER A OG  1 
ATOM   2450 N N   . LEU A 1 359 ? 10.288  -19.320 -15.035 1.00 33.37 ?  323 LEU A N   1 
ATOM   2451 C CA  . LEU A 1 359 ? 9.357   -19.101 -16.133 1.00 35.57 ?  323 LEU A CA  1 
ATOM   2452 C C   . LEU A 1 359 ? 8.565   -20.355 -16.520 1.00 37.23 ?  323 LEU A C   1 
ATOM   2453 O O   . LEU A 1 359 ? 7.941   -20.372 -17.591 1.00 41.13 ?  323 LEU A O   1 
ATOM   2454 C CB  . LEU A 1 359 ? 10.112  -18.551 -17.349 1.00 30.91 ?  323 LEU A CB  1 
ATOM   2455 C CG  . LEU A 1 359 ? 10.728  -17.194 -17.066 1.00 28.46 ?  323 LEU A CG  1 
ATOM   2456 C CD1 . LEU A 1 359 ? 11.468  -16.672 -18.295 1.00 35.15 ?  323 LEU A CD1 1 
ATOM   2457 C CD2 . LEU A 1 359 ? 9.632   -16.242 -16.642 1.00 29.26 ?  323 LEU A CD2 1 
ATOM   2458 N N   . HIS A 1 360 ? 8.568   -21.393 -15.684 1.00 36.85 ?  324 HIS A N   1 
ATOM   2459 C CA  . HIS A 1 360 ? 7.760   -22.583 -15.914 1.00 37.11 ?  324 HIS A CA  1 
ATOM   2460 C C   . HIS A 1 360 ? 6.536   -22.596 -15.002 1.00 39.09 ?  324 HIS A C   1 
ATOM   2461 O O   . HIS A 1 360 ? 6.516   -21.996 -13.921 1.00 34.66 ?  324 HIS A O   1 
ATOM   2462 C CB  . HIS A 1 360 ? 8.570   -23.866 -15.687 1.00 37.43 ?  324 HIS A CB  1 
ATOM   2463 C CG  . HIS A 1 360 ? 9.532   -24.183 -16.788 1.00 36.75 ?  324 HIS A CG  1 
ATOM   2464 N ND1 . HIS A 1 360 ? 9.493   -25.366 -17.499 1.00 43.61 ?  324 HIS A ND1 1 
ATOM   2465 C CD2 . HIS A 1 360 ? 10.569  -23.475 -17.292 1.00 38.09 ?  324 HIS A CD2 1 
ATOM   2466 C CE1 . HIS A 1 360 ? 10.460  -25.366 -18.400 1.00 44.61 ?  324 HIS A CE1 1 
ATOM   2467 N NE2 . HIS A 1 360 ? 11.132  -24.233 -18.292 1.00 47.49 ?  324 HIS A NE2 1 
ATOM   2468 N N   . GLU A 1 361 ? 5.506   -23.301 -15.448 1.00 39.91 ?  325 GLU A N   1 
ATOM   2469 C CA  . GLU A 1 361 ? 4.328   -23.544 -14.629 1.00 41.45 ?  325 GLU A CA  1 
ATOM   2470 C C   . GLU A 1 361 ? 4.474   -24.922 -13.996 1.00 40.81 ?  325 GLU A C   1 
ATOM   2471 O O   . GLU A 1 361 ? 4.503   -25.937 -14.698 1.00 42.40 ?  325 GLU A O   1 
ATOM   2472 C CB  . GLU A 1 361 ? 3.037   -23.439 -15.440 1.00 42.43 ?  325 GLU A CB  1 
ATOM   2473 C CG  . GLU A 1 361 ? 1.769   -23.381 -14.582 1.00 39.87 ?  325 GLU A CG  1 
ATOM   2474 C CD  . GLU A 1 361 ? 1.587   -22.047 -13.835 1.00 44.06 ?  325 GLU A CD  1 
ATOM   2475 O OE1 . GLU A 1 361 ? 2.492   -21.647 -13.066 1.00 37.42 ?  325 GLU A OE1 1 
ATOM   2476 O OE2 . GLU A 1 361 ? 0.525   -21.402 -14.000 1.00 46.73 ?  325 GLU A OE2 1 
ATOM   2477 N N   . PHE A 1 362 ? 4.612   -24.946 -12.674 1.00 39.30 ?  326 PHE A N   1 
ATOM   2478 C CA  . PHE A 1 362 ? 4.448   -26.172 -11.913 1.00 38.63 ?  326 PHE A CA  1 
ATOM   2479 C C   . PHE A 1 362 ? 3.065   -26.113 -11.290 1.00 37.34 ?  326 PHE A C   1 
ATOM   2480 O O   . PHE A 1 362 ? 2.844   -25.307 -10.368 1.00 33.54 ?  326 PHE A O   1 
ATOM   2481 C CB  . PHE A 1 362 ? 5.531   -26.306 -10.843 1.00 36.68 ?  326 PHE A CB  1 
ATOM   2482 C CG  . PHE A 1 362 ? 6.916   -26.058 -11.363 1.00 35.71 ?  326 PHE A CG  1 
ATOM   2483 C CD1 . PHE A 1 362 ? 7.662   -27.097 -11.899 1.00 39.69 ?  326 PHE A CD1 1 
ATOM   2484 C CD2 . PHE A 1 362 ? 7.474   -24.780 -11.331 1.00 37.07 ?  326 PHE A CD2 1 
ATOM   2485 C CE1 . PHE A 1 362 ? 8.947   -26.873 -12.394 1.00 42.36 ?  326 PHE A CE1 1 
ATOM   2486 C CE2 . PHE A 1 362 ? 8.755   -24.544 -11.824 1.00 37.42 ?  326 PHE A CE2 1 
ATOM   2487 C CZ  . PHE A 1 362 ? 9.496   -25.595 -12.358 1.00 35.67 ?  326 PHE A CZ  1 
ATOM   2488 N N   . PRO A 1 363 ? 2.098   -26.895 -11.781 1.00 38.41 ?  327 PRO A N   1 
ATOM   2489 C CA  . PRO A 1 363 ? 0.693   -26.629 -11.424 1.00 35.82 ?  327 PRO A CA  1 
ATOM   2490 C C   . PRO A 1 363 ? 0.413   -26.728 -9.940  1.00 36.40 ?  327 PRO A C   1 
ATOM   2491 O O   . PRO A 1 363 ? -0.473  -26.021 -9.438  1.00 35.85 ?  327 PRO A O   1 
ATOM   2492 C CB  . PRO A 1 363 ? -0.083  -27.697 -12.212 1.00 38.81 ?  327 PRO A CB  1 
ATOM   2493 C CG  . PRO A 1 363 ? 0.925   -28.761 -12.542 1.00 39.33 ?  327 PRO A CG  1 
ATOM   2494 C CD  . PRO A 1 363 ? 2.235   -28.038 -12.704 1.00 42.04 ?  327 PRO A CD  1 
ATOM   2495 N N   . GLU A 1 364 ? 1.138   -27.587 -9.223  1.00 31.03 ?  328 GLU A N   1 
ATOM   2496 C CA  . GLU A 1 364 ? 0.870   -27.767 -7.801  1.00 35.25 ?  328 GLU A CA  1 
ATOM   2497 C C   . GLU A 1 364 ? 1.041   -26.456 -7.039  1.00 33.07 ?  328 GLU A C   1 
ATOM   2498 O O   . GLU A 1 364 ? 0.262   -26.152 -6.133  1.00 32.16 ?  328 GLU A O   1 
ATOM   2499 C CB  . GLU A 1 364 ? 1.787   -28.856 -7.234  1.00 31.11 ?  328 GLU A CB  1 
ATOM   2500 C CG  . GLU A 1 364 ? 1.536   -30.251 -7.807  1.00 38.05 ?  328 GLU A CG  1 
ATOM   2501 C CD  . GLU A 1 364 ? 2.374   -30.571 -9.054  1.00 40.12 ?  328 GLU A CD  1 
ATOM   2502 O OE1 . GLU A 1 364 ? 2.799   -29.627 -9.764  1.00 38.83 ?  328 GLU A OE1 1 
ATOM   2503 O OE2 . GLU A 1 364 ? 2.610   -31.776 -9.321  1.00 39.77 ?  328 GLU A OE2 1 
ATOM   2504 N N   . LEU A 1 365 ? 2.035   -25.648 -7.416  1.00 32.14 ?  329 LEU A N   1 
ATOM   2505 C CA  . LEU A 1 365 ? 2.276   -24.384 -6.724  1.00 32.93 ?  329 LEU A CA  1 
ATOM   2506 C C   . LEU A 1 365 ? 1.099   -23.423 -6.823  1.00 32.60 ?  329 LEU A C   1 
ATOM   2507 O O   . LEU A 1 365 ? 0.961   -22.538 -5.974  1.00 32.36 ?  329 LEU A O   1 
ATOM   2508 C CB  . LEU A 1 365 ? 3.537   -23.720 -7.282  1.00 32.95 ?  329 LEU A CB  1 
ATOM   2509 C CG  . LEU A 1 365 ? 4.750   -24.643 -7.370  1.00 29.13 ?  329 LEU A CG  1 
ATOM   2510 C CD1 . LEU A 1 365 ? 6.017   -23.907 -7.804  1.00 29.35 ?  329 LEU A CD1 1 
ATOM   2511 C CD2 . LEU A 1 365 ? 4.972   -25.334 -6.040  1.00 29.26 ?  329 LEU A CD2 1 
ATOM   2512 N N   . ARG A 1 366 ? 0.246   -23.558 -7.811  1.00 32.88 ?  330 ARG A N   1 
ATOM   2513 C CA  . ARG A 1 366 ? -0.854  -22.632 -7.993  1.00 32.32 ?  330 ARG A CA  1 
ATOM   2514 C C   . ARG A 1 366 ? -2.194  -23.137 -7.476  1.00 33.58 ?  330 ARG A C   1 
ATOM   2515 O O   . ARG A 1 366 ? -3.204  -22.486 -7.611  1.00 38.22 ?  330 ARG A O   1 
ATOM   2516 C CB  . ARG A 1 366 ? -0.976  -22.340 -9.452  1.00 35.66 ?  330 ARG A CB  1 
ATOM   2517 C CG  . ARG A 1 366 ? 0.352   -22.031 -10.114 1.00 38.26 ?  330 ARG A CG  1 
ATOM   2518 C CD  . ARG A 1 366 ? 0.764   -20.610 -9.802  1.00 39.94 ?  330 ARG A CD  1 
ATOM   2519 N NE  . ARG A 1 366 ? 0.016   -19.648 -10.598 1.00 43.98 ?  330 ARG A NE  1 
ATOM   2520 C CZ  . ARG A 1 366 ? -0.467  -18.505 -10.127 1.00 45.22 ?  330 ARG A CZ  1 
ATOM   2521 N NH1 . ARG A 1 366 ? -0.285  -18.177 -8.855  1.00 34.43 ?  330 ARG A NH1 1 
ATOM   2522 N NH2 . ARG A 1 366 ? -1.131  -17.689 -10.930 1.00 41.97 ?  330 ARG A NH2 1 
ATOM   2523 N N   . LYS A 1 367 ? -2.190  -24.297 -6.874  1.00 33.65 ?  331 LYS A N   1 
ATOM   2524 C CA  . LYS A 1 367 ? -3.409  -24.886 -6.341  1.00 31.44 ?  331 LYS A CA  1 
ATOM   2525 C C   . LYS A 1 367 ? -3.748  -24.311 -4.975  1.00 32.67 ?  331 LYS A C   1 
ATOM   2526 O O   . LYS A 1 367 ? -2.861  -23.975 -4.184  1.00 32.89 ?  331 LYS A O   1 
ATOM   2527 C CB  . LYS A 1 367 ? -3.260  -26.398 -6.222  1.00 36.45 ?  331 LYS A CB  1 
ATOM   2528 C CG  . LYS A 1 367 ? -3.228  -27.104 -7.550  1.00 37.90 ?  331 LYS A CG  1 
ATOM   2529 C CD  . LYS A 1 367 ? -3.846  -28.485 -7.446  1.00 40.48 ?  331 LYS A CD  1 
ATOM   2530 C CE  . LYS A 1 367 ? -2.944  -29.501 -8.085  1.00 40.84 ?  331 LYS A CE  1 
ATOM   2531 N NZ  . LYS A 1 367 ? -3.258  -29.710 -9.525  1.00 44.10 ?  331 LYS A NZ  1 
ATOM   2532 N N   . ALA A 1 368 ? -5.048  -24.229 -4.694  1.00 28.89 ?  332 ALA A N   1 
ATOM   2533 C CA  . ALA A 1 368 ? -5.504  -23.745 -3.399  1.00 27.81 ?  332 ALA A CA  1 
ATOM   2534 C C   . ALA A 1 368 ? -4.900  -24.579 -2.277  1.00 29.96 ?  332 ALA A C   1 
ATOM   2535 O O   . ALA A 1 368 ? -4.905  -25.814 -2.327  1.00 30.34 ?  332 ALA A O   1 
ATOM   2536 C CB  . ALA A 1 368 ? -7.024  -23.785 -3.323  1.00 24.44 ?  332 ALA A CB  1 
ATOM   2537 N N   . LEU A 1 369 ? -4.377  -23.898 -1.261  1.00 27.95 ?  333 LEU A N   1 
ATOM   2538 C CA  . LEU A 1 369 ? -3.735  -24.561 -0.131  1.00 27.05 ?  333 LEU A CA  1 
ATOM   2539 C C   . LEU A 1 369 ? -4.470  -24.273 1.166   1.00 27.50 ?  333 LEU A C   1 
ATOM   2540 O O   . LEU A 1 369 ? -4.984  -25.201 1.811   1.00 25.22 ?  333 LEU A O   1 
ATOM   2541 C CB  . LEU A 1 369 ? -2.270  -24.119 -0.023  1.00 25.56 ?  333 LEU A CB  1 
ATOM   2542 C CG  . LEU A 1 369 ? -1.493  -24.656 1.184   1.00 23.82 ?  333 LEU A CG  1 
ATOM   2543 C CD1 . LEU A 1 369 ? -1.242  -26.136 1.043   1.00 25.40 ?  333 LEU A CD1 1 
ATOM   2544 C CD2 . LEU A 1 369 ? -0.174  -23.924 1.322   1.00 25.96 ?  333 LEU A CD2 1 
ATOM   2545 N N   . GLY A 1 370 ? -4.551  -23.005 1.551   1.00 24.29 ?  334 GLY A N   1 
ATOM   2546 C CA  . GLY A 1 370 ? -5.253  -22.611 2.741   1.00 24.86 ?  334 GLY A CA  1 
ATOM   2547 C C   . GLY A 1 370 ? -4.400  -22.762 3.980   1.00 25.80 ?  334 GLY A C   1 
ATOM   2548 O O   . GLY A 1 370 ? -3.311  -23.355 3.951   1.00 27.19 ?  334 GLY A O   1 
ATOM   2549 N N   . PRO A 1 371 ? -4.880  -22.204 5.097   1.00 23.67 ?  335 PRO A N   1 
ATOM   2550 C CA  . PRO A 1 371 ? -4.086  -22.234 6.325   1.00 24.22 ?  335 PRO A CA  1 
ATOM   2551 C C   . PRO A 1 371 ? -3.912  -23.651 6.836   1.00 24.98 ?  335 PRO A C   1 
ATOM   2552 O O   . PRO A 1 371 ? -4.773  -24.520 6.615   1.00 22.42 ?  335 PRO A O   1 
ATOM   2553 C CB  . PRO A 1 371 ? -4.911  -21.378 7.307   1.00 27.88 ?  335 PRO A CB  1 
ATOM   2554 C CG  . PRO A 1 371 ? -6.131  -20.888 6.567   1.00 28.47 ?  335 PRO A CG  1 
ATOM   2555 C CD  . PRO A 1 371 ? -5.950  -21.191 5.118   1.00 28.98 ?  335 PRO A CD  1 
ATOM   2556 N N   . PRO A 1 372 ? -2.795  -23.939 7.511   1.00 26.37 ?  336 PRO A N   1 
ATOM   2557 C CA  . PRO A 1 372 ? -2.628  -25.271 8.101   1.00 26.63 ?  336 PRO A CA  1 
ATOM   2558 C C   . PRO A 1 372 ? -3.666  -25.470 9.185   1.00 27.82 ?  336 PRO A C   1 
ATOM   2559 O O   . PRO A 1 372 ? -4.024  -24.532 9.904   1.00 27.44 ?  336 PRO A O   1 
ATOM   2560 C CB  . PRO A 1 372 ? -1.210  -25.250 8.689   1.00 25.52 ?  336 PRO A CB  1 
ATOM   2561 C CG  . PRO A 1 372 ? -0.663  -23.839 8.431   1.00 25.52 ?  336 PRO A CG  1 
ATOM   2562 C CD  . PRO A 1 372 ? -1.784  -22.971 7.976   1.00 25.49 ?  336 PRO A CD  1 
ATOM   2563 N N   . LYS A 1 373 ? -4.168  -26.699 9.281   1.00 23.72 ?  337 LYS A N   1 
ATOM   2564 C CA  . LYS A 1 373 ? -5.088  -27.032 10.364  1.00 26.65 ?  337 LYS A CA  1 
ATOM   2565 C C   . LYS A 1 373 ? -4.347  -27.396 11.638  1.00 29.91 ?  337 LYS A C   1 
ATOM   2566 O O   . LYS A 1 373 ? -4.945  -27.401 12.718  1.00 30.59 ?  337 LYS A O   1 
ATOM   2567 C CB  . LYS A 1 373 ? -5.998  -28.181 9.932   1.00 24.62 ?  337 LYS A CB  1 
ATOM   2568 C CG  . LYS A 1 373 ? -7.086  -27.754 8.974   1.00 26.81 ?  337 LYS A CG  1 
ATOM   2569 C CD  . LYS A 1 373 ? -7.673  -28.944 8.203   1.00 31.76 ?  337 LYS A CD  1 
ATOM   2570 C CE  . LYS A 1 373 ? -9.146  -28.750 7.879   1.00 37.64 ?  337 LYS A CE  1 
ATOM   2571 N NZ  . LYS A 1 373 ? -9.665  -29.822 6.961   1.00 38.84 ?  337 LYS A NZ  1 
ATOM   2572 N N   . GLY A 1 374 ? -3.063  -27.715 11.526  1.00 28.70 ?  338 GLY A N   1 
ATOM   2573 C CA  . GLY A 1 374 ? -2.217  -27.904 12.685  1.00 26.16 ?  338 GLY A CA  1 
ATOM   2574 C C   . GLY A 1 374 ? -0.818  -28.218 12.213  1.00 27.72 ?  338 GLY A C   1 
ATOM   2575 O O   . GLY A 1 374 ? -0.535  -28.248 11.008  1.00 25.52 ?  338 GLY A O   1 
ATOM   2576 N N   . ALA A 1 375 ? 0.058   -28.449 13.185  1.00 23.33 ?  339 ALA A N   1 
ATOM   2577 C CA  . ALA A 1 375 ? 1.401   -28.924 12.905  1.00 24.12 ?  339 ALA A CA  1 
ATOM   2578 C C   . ALA A 1 375 ? 1.348   -30.286 12.229  1.00 28.74 ?  339 ALA A C   1 
ATOM   2579 O O   . ALA A 1 375 ? 0.315   -30.964 12.201  1.00 29.29 ?  339 ALA A O   1 
ATOM   2580 C CB  . ALA A 1 375 ? 2.215   -29.023 14.193  1.00 27.64 ?  339 ALA A CB  1 
ATOM   2581 N N   . TYR A 1 376 ? 2.488   -30.695 11.682  1.00 26.17 ?  340 TYR A N   1 
ATOM   2582 C CA  . TYR A 1 376 ? 2.540   -32.007 11.067  1.00 27.10 ?  340 TYR A CA  1 
ATOM   2583 C C   . TYR A 1 376 ? 2.497   -33.097 12.136  1.00 27.16 ?  340 TYR A C   1 
ATOM   2584 O O   . TYR A 1 376 ? 2.759   -32.867 13.321  1.00 28.60 ?  340 TYR A O   1 
ATOM   2585 C CB  . TYR A 1 376 ? 3.792   -32.155 10.194  1.00 26.04 ?  340 TYR A CB  1 
ATOM   2586 C CG  . TYR A 1 376 ? 5.111   -32.268 10.951  1.00 29.09 ?  340 TYR A CG  1 
ATOM   2587 C CD1 . TYR A 1 376 ? 5.523   -33.486 11.511  1.00 29.00 ?  340 TYR A CD1 1 
ATOM   2588 C CD2 . TYR A 1 376 ? 5.965   -31.169 11.067  1.00 27.06 ?  340 TYR A CD2 1 
ATOM   2589 C CE1 . TYR A 1 376 ? 6.718   -33.593 12.186  1.00 27.35 ?  340 TYR A CE1 1 
ATOM   2590 C CE2 . TYR A 1 376 ? 7.172   -31.273 11.741  1.00 28.95 ?  340 TYR A CE2 1 
ATOM   2591 C CZ  . TYR A 1 376 ? 7.543   -32.488 12.293  1.00 34.34 ?  340 TYR A CZ  1 
ATOM   2592 O OH  . TYR A 1 376 ? 8.748   -32.598 12.960  1.00 33.21 ?  340 TYR A OH  1 
ATOM   2593 N N   . ASP A 1 377 ? 2.178   -34.301 11.689  1.00 28.00 ?  341 ASP A N   1 
ATOM   2594 C CA  . ASP A 1 377 ? 2.181   -35.487 12.527  1.00 30.89 ?  341 ASP A CA  1 
ATOM   2595 C C   . ASP A 1 377 ? 3.227   -36.447 11.990  1.00 29.91 ?  341 ASP A C   1 
ATOM   2596 O O   . ASP A 1 377 ? 3.210   -36.787 10.799  1.00 28.10 ?  341 ASP A O   1 
ATOM   2597 C CB  . ASP A 1 377 ? 0.808   -36.177 12.540  1.00 34.29 ?  341 ASP A CB  1 
ATOM   2598 C CG  . ASP A 1 377 ? -0.242  -35.407 13.324  1.00 34.04 ?  341 ASP A CG  1 
ATOM   2599 O OD1 . ASP A 1 377 ? 0.089   -34.740 14.328  1.00 32.71 ?  341 ASP A OD1 1 
ATOM   2600 O OD2 . ASP A 1 377 ? -1.429  -35.494 12.938  1.00 39.10 ?  341 ASP A OD2 1 
ATOM   2601 N N   . ARG A 1 378 ? 4.140   -36.869 12.860  1.00 35.93 ?  342 ARG A N   1 
ATOM   2602 C CA  . ARG A 1 378 ? 5.042   -37.973 12.544  1.00 36.61 ?  342 ARG A CA  1 
ATOM   2603 C C   . ARG A 1 378 ? 4.270   -39.267 12.758  1.00 33.67 ?  342 ARG A C   1 
ATOM   2604 O O   . ARG A 1 378 ? 3.979   -39.632 13.900  1.00 35.03 ?  342 ARG A O   1 
ATOM   2605 C CB  . ARG A 1 378 ? 6.295   -37.925 13.418  1.00 34.31 ?  342 ARG A CB  1 
ATOM   2606 C CG  . ARG A 1 378 ? 7.430   -38.804 12.926  1.00 33.54 ?  342 ARG A CG  1 
ATOM   2607 C CD  . ARG A 1 378 ? 8.704   -38.599 13.757  1.00 33.04 ?  342 ARG A CD  1 
ATOM   2608 N NE  . ARG A 1 378 ? 9.857   -39.304 13.195  1.00 36.75 ?  342 ARG A NE  1 
ATOM   2609 C CZ  . ARG A 1 378 ? 11.123  -39.074 13.531  1.00 40.36 ?  342 ARG A CZ  1 
ATOM   2610 N NH1 . ARG A 1 378 ? 11.444  -38.179 14.451  1.00 34.05 ?  342 ARG A NH1 1 
ATOM   2611 N NH2 . ARG A 1 378 ? 12.091  -39.763 12.932  1.00 37.94 ?  342 ARG A NH2 1 
ATOM   2612 N N   . THR A 1 379 ? 3.938   -39.955 11.658  1.00 36.26 ?  343 THR A N   1 
ATOM   2613 C CA  . THR A 1 379 ? 3.035   -41.106 11.716  1.00 36.17 ?  343 THR A CA  1 
ATOM   2614 C C   . THR A 1 379 ? 3.473   -42.141 12.749  1.00 38.82 ?  343 THR A C   1 
ATOM   2615 O O   . THR A 1 379 ? 2.631   -42.773 13.391  1.00 40.97 ?  343 THR A O   1 
ATOM   2616 C CB  . THR A 1 379 ? 2.923   -41.770 10.345  1.00 39.49 ?  343 THR A CB  1 
ATOM   2617 O OG1 . THR A 1 379 ? 2.628   -40.783 9.348   1.00 37.54 ?  343 THR A OG1 1 
ATOM   2618 C CG2 . THR A 1 379 ? 1.806   -42.813 10.365  1.00 38.86 ?  343 THR A CG2 1 
ATOM   2619 N N   . THR A 1 380 ? 4.776   -42.350 12.908  1.00 36.28 ?  344 THR A N   1 
ATOM   2620 C CA  . THR A 1 380 ? 5.312   -43.192 13.971  1.00 38.90 ?  344 THR A CA  1 
ATOM   2621 C C   . THR A 1 380 ? 6.529   -42.498 14.556  1.00 40.46 ?  344 THR A C   1 
ATOM   2622 O O   . THR A 1 380 ? 7.291   -41.861 13.817  1.00 41.33 ?  344 THR A O   1 
ATOM   2623 C CB  . THR A 1 380 ? 5.717   -44.593 13.480  1.00 40.17 ?  344 THR A CB  1 
ATOM   2624 O OG1 . THR A 1 380 ? 6.986   -44.508 12.817  1.00 42.21 ?  344 THR A OG1 1 
ATOM   2625 C CG2 . THR A 1 380 ? 4.669   -45.179 12.529  1.00 40.52 ?  344 THR A CG2 1 
ATOM   2626 N N   . PRO A 1 381 ? 6.755   -42.625 15.869  1.00 38.19 ?  345 PRO A N   1 
ATOM   2627 C CA  . PRO A 1 381 ? 7.703   -41.720 16.542  1.00 38.05 ?  345 PRO A CA  1 
ATOM   2628 C C   . PRO A 1 381 ? 9.136   -41.826 16.040  1.00 39.60 ?  345 PRO A C   1 
ATOM   2629 O O   . PRO A 1 381 ? 9.917   -40.890 16.245  1.00 36.57 ?  345 PRO A O   1 
ATOM   2630 C CB  . PRO A 1 381 ? 7.593   -42.132 18.018  1.00 36.84 ?  345 PRO A CB  1 
ATOM   2631 C CG  . PRO A 1 381 ? 6.269   -42.845 18.121  1.00 37.32 ?  345 PRO A CG  1 
ATOM   2632 C CD  . PRO A 1 381 ? 6.136   -43.569 16.815  1.00 40.21 ?  345 PRO A CD  1 
ATOM   2633 N N   . ASP A 1 382 ? 9.502   -42.927 15.389  1.00 37.80 ?  346 ASP A N   1 
ATOM   2634 C CA  . ASP A 1 382 ? 10.831  -43.102 14.841  1.00 38.19 ?  346 ASP A CA  1 
ATOM   2635 C C   . ASP A 1 382 ? 10.805  -43.342 13.343  1.00 39.38 ?  346 ASP A C   1 
ATOM   2636 O O   . ASP A 1 382 ? 11.861  -43.598 12.750  1.00 40.47 ?  346 ASP A O   1 
ATOM   2637 C CB  . ASP A 1 382 ? 11.543  -44.265 15.541  1.00 40.62 ?  346 ASP A CB  1 
ATOM   2638 C CG  . ASP A 1 382 ? 10.834  -45.604 15.322  1.00 43.44 ?  346 ASP A CG  1 
ATOM   2639 O OD1 . ASP A 1 382 ? 9.641   -45.607 14.934  1.00 36.85 ?  346 ASP A OD1 1 
ATOM   2640 O OD2 . ASP A 1 382 ? 11.479  -46.656 15.543  1.00 46.17 ?  346 ASP A OD2 1 
ATOM   2641 N N   . GLY A 1 383 ? 9.633   -43.284 12.718  1.00 34.29 ?  347 GLY A N   1 
ATOM   2642 C CA  . GLY A 1 383 ? 9.539   -43.465 11.289  1.00 35.34 ?  347 GLY A CA  1 
ATOM   2643 C C   . GLY A 1 383 ? 9.819   -42.174 10.558  1.00 37.94 ?  347 GLY A C   1 
ATOM   2644 O O   . GLY A 1 383 ? 10.093  -41.128 11.146  1.00 38.65 ?  347 GLY A O   1 
ATOM   2645 N N   . TRP A 1 384 ? 9.759   -42.251 9.236   1.00 35.97 ?  348 TRP A N   1 
ATOM   2646 C CA  . TRP A 1 384 ? 10.084  -41.109 8.394   1.00 35.07 ?  348 TRP A CA  1 
ATOM   2647 C C   . TRP A 1 384 ? 8.915   -40.772 7.480   1.00 32.00 ?  348 TRP A C   1 
ATOM   2648 O O   . TRP A 1 384 ? 9.095   -40.261 6.376   1.00 30.88 ?  348 TRP A O   1 
ATOM   2649 C CB  . TRP A 1 384 ? 11.372  -41.372 7.616   1.00 31.37 ?  348 TRP A CB  1 
ATOM   2650 C CG  . TRP A 1 384 ? 12.511  -41.521 8.561   1.00 34.37 ?  348 TRP A CG  1 
ATOM   2651 C CD1 . TRP A 1 384 ? 13.072  -42.687 8.993   1.00 38.07 ?  348 TRP A CD1 1 
ATOM   2652 C CD2 . TRP A 1 384 ? 13.207  -40.467 9.238   1.00 38.54 ?  348 TRP A CD2 1 
ATOM   2653 N NE1 . TRP A 1 384 ? 14.094  -42.427 9.881   1.00 39.82 ?  348 TRP A NE1 1 
ATOM   2654 C CE2 . TRP A 1 384 ? 14.195  -41.070 10.051  1.00 40.54 ?  348 TRP A CE2 1 
ATOM   2655 C CE3 . TRP A 1 384 ? 13.101  -39.068 9.230   1.00 39.41 ?  348 TRP A CE3 1 
ATOM   2656 C CZ2 . TRP A 1 384 ? 15.064  -40.326 10.848  1.00 42.10 ?  348 TRP A CZ2 1 
ATOM   2657 C CZ3 . TRP A 1 384 ? 13.969  -38.329 10.026  1.00 35.82 ?  348 TRP A CZ3 1 
ATOM   2658 C CH2 . TRP A 1 384 ? 14.937  -38.959 10.819  1.00 41.41 ?  348 TRP A CH2 1 
ATOM   2659 N N   . GLU A 1 385 ? 7.709   -41.083 7.940   1.00 33.83 ?  349 GLU A N   1 
ATOM   2660 C CA  . GLU A 1 385 ? 6.480   -40.646 7.295   1.00 30.71 ?  349 GLU A CA  1 
ATOM   2661 C C   . GLU A 1 385 ? 5.936   -39.446 8.049   1.00 28.91 ?  349 GLU A C   1 
ATOM   2662 O O   . GLU A 1 385 ? 5.969   -39.407 9.285   1.00 29.71 ?  349 GLU A O   1 
ATOM   2663 C CB  . GLU A 1 385 ? 5.430   -41.756 7.262   1.00 32.17 ?  349 GLU A CB  1 
ATOM   2664 C CG  . GLU A 1 385 ? 5.667   -42.811 6.192   1.00 39.46 ?  349 GLU A CG  1 
ATOM   2665 C CD  . GLU A 1 385 ? 4.526   -43.829 6.111   1.00 41.08 ?  349 GLU A CD  1 
ATOM   2666 O OE1 . GLU A 1 385 ? 3.353   -43.407 6.097   1.00 42.51 ?  349 GLU A OE1 1 
ATOM   2667 O OE2 . GLU A 1 385 ? 4.805   -45.042 6.063   1.00 40.69 ?  349 GLU A OE2 1 
ATOM   2668 N N   . PHE A 1 386 ? 5.441   -38.464 7.300   1.00 27.98 ?  350 PHE A N   1 
ATOM   2669 C CA  . PHE A 1 386 ? 4.952   -37.230 7.883   1.00 25.64 ?  350 PHE A CA  1 
ATOM   2670 C C   . PHE A 1 386 ? 3.726   -36.778 7.118   1.00 28.93 ?  350 PHE A C   1 
ATOM   2671 O O   . PHE A 1 386 ? 3.684   -36.867 5.886   1.00 30.81 ?  350 PHE A O   1 
ATOM   2672 C CB  . PHE A 1 386 ? 6.039   -36.156 7.851   1.00 25.05 ?  350 PHE A CB  1 
ATOM   2673 C CG  . PHE A 1 386 ? 7.262   -36.552 8.570   1.00 25.18 ?  350 PHE A CG  1 
ATOM   2674 C CD1 . PHE A 1 386 ? 7.395   -36.283 9.922   1.00 26.33 ?  350 PHE A CD1 1 
ATOM   2675 C CD2 . PHE A 1 386 ? 8.270   -37.243 7.916   1.00 25.45 ?  350 PHE A CD2 1 
ATOM   2676 C CE1 . PHE A 1 386 ? 8.533   -36.674 10.602  1.00 28.60 ?  350 PHE A CE1 1 
ATOM   2677 C CE2 . PHE A 1 386 ? 9.405   -37.630 8.591   1.00 29.43 ?  350 PHE A CE2 1 
ATOM   2678 C CZ  . PHE A 1 386 ? 9.537   -37.355 9.934   1.00 28.03 ?  350 PHE A CZ  1 
ATOM   2679 N N   . THR A 1 387 ? 2.728   -36.305 7.854   1.00 27.78 ?  351 THR A N   1 
ATOM   2680 C CA  . THR A 1 387 ? 1.497   -35.817 7.261   1.00 28.43 ?  351 THR A CA  1 
ATOM   2681 C C   . THR A 1 387 ? 1.146   -34.462 7.848   1.00 25.63 ?  351 THR A C   1 
ATOM   2682 O O   . THR A 1 387 ? 1.446   -34.158 9.008   1.00 24.22 ?  351 THR A O   1 
ATOM   2683 C CB  . THR A 1 387 ? 0.329   -36.797 7.482   1.00 28.49 ?  351 THR A CB  1 
ATOM   2684 O OG1 . THR A 1 387 ? 0.033   -36.886 8.882   1.00 24.63 ?  351 THR A OG1 1 
ATOM   2685 C CG2 . THR A 1 387 ? 0.718   -38.165 6.979   1.00 29.84 ?  351 THR A CG2 1 
ATOM   2686 N N   . ARG A 1 388 ? 0.476   -33.654 7.042   1.00 27.42 ?  352 ARG A N   1 
ATOM   2687 C CA  . ARG A 1 388 ? -0.019  -32.389 7.555   1.00 26.63 ?  352 ARG A CA  1 
ATOM   2688 C C   . ARG A 1 388 ? -1.290  -32.027 6.815   1.00 24.68 ?  352 ARG A C   1 
ATOM   2689 O O   . ARG A 1 388 ? -1.396  -32.220 5.599   1.00 26.11 ?  352 ARG A O   1 
ATOM   2690 C CB  . ARG A 1 388 ? 1.007   -31.262 7.415   1.00 19.33 ?  352 ARG A CB  1 
ATOM   2691 C CG  . ARG A 1 388 ? 0.635   -30.037 8.208   1.00 23.67 ?  352 ARG A CG  1 
ATOM   2692 C CD  . ARG A 1 388 ? 1.736   -29.004 8.160   1.00 23.10 ?  352 ARG A CD  1 
ATOM   2693 N NE  . ARG A 1 388 ? 1.472   -27.882 9.053   1.00 19.63 ?  352 ARG A NE  1 
ATOM   2694 C CZ  . ARG A 1 388 ? 2.214   -26.788 9.083   1.00 24.94 ?  352 ARG A CZ  1 
ATOM   2695 N NH1 . ARG A 1 388 ? 3.282   -26.655 8.299   1.00 21.83 ?  352 ARG A NH1 1 
ATOM   2696 N NH2 . ARG A 1 388 ? 1.876   -25.802 9.909   1.00 23.08 ?  352 ARG A NH2 1 
ATOM   2697 N N   . GLU A 1 389 ? -2.242  -31.491 7.568   1.00 27.13 ?  353 GLU A N   1 
ATOM   2698 C CA  . GLU A 1 389 ? -3.535  -31.087 7.047   1.00 26.39 ?  353 GLU A CA  1 
ATOM   2699 C C   . GLU A 1 389 ? -3.565  -29.577 6.852   1.00 26.83 ?  353 GLU A C   1 
ATOM   2700 O O   . GLU A 1 389 ? -3.278  -28.819 7.784   1.00 24.06 ?  353 GLU A O   1 
ATOM   2701 C CB  . GLU A 1 389 ? -4.652  -31.522 7.997   1.00 29.89 ?  353 GLU A CB  1 
ATOM   2702 C CG  . GLU A 1 389 ? -5.000  -32.970 7.820   1.00 33.65 ?  353 GLU A CG  1 
ATOM   2703 C CD  . GLU A 1 389 ? -5.435  -33.256 6.408   1.00 38.77 ?  353 GLU A CD  1 
ATOM   2704 O OE1 . GLU A 1 389 ? -6.267  -32.482 5.862   1.00 41.08 ?  353 GLU A OE1 1 
ATOM   2705 O OE2 . GLU A 1 389 ? -4.937  -34.247 5.844   1.00 38.01 ?  353 GLU A OE2 1 
ATOM   2706 N N   . PHE A 1 390 ? -3.894  -29.152 5.640   1.00 24.04 ?  354 PHE A N   1 
ATOM   2707 C CA  . PHE A 1 390 ? -4.211  -27.763 5.356   1.00 24.33 ?  354 PHE A CA  1 
ATOM   2708 C C   . PHE A 1 390 ? -5.695  -27.647 5.022   1.00 29.25 ?  354 PHE A C   1 
ATOM   2709 O O   . PHE A 1 390 ? -6.406  -28.639 4.851   1.00 30.46 ?  354 PHE A O   1 
ATOM   2710 C CB  . PHE A 1 390 ? -3.341  -27.223 4.215   1.00 24.96 ?  354 PHE A CB  1 
ATOM   2711 C CG  . PHE A 1 390 ? -1.863  -27.155 4.544   1.00 25.99 ?  354 PHE A CG  1 
ATOM   2712 C CD1 . PHE A 1 390 ? -1.074  -28.294 4.512   1.00 19.54 ?  354 PHE A CD1 1 
ATOM   2713 C CD2 . PHE A 1 390 ? -1.260  -25.946 4.865   1.00 26.75 ?  354 PHE A CD2 1 
ATOM   2714 C CE1 . PHE A 1 390 ? 0.269   -28.236 4.804   1.00 24.39 ?  354 PHE A CE1 1 
ATOM   2715 C CE2 . PHE A 1 390 ? 0.104   -25.884 5.161   1.00 24.52 ?  354 PHE A CE2 1 
ATOM   2716 C CZ  . PHE A 1 390 ? 0.863   -27.032 5.131   1.00 23.17 ?  354 PHE A CZ  1 
ATOM   2717 N N   . GLU A 1 391 ? -6.170  -26.409 4.934   1.00 30.06 ?  355 GLU A N   1 
ATOM   2718 C CA  . GLU A 1 391 ? -7.586  -26.187 4.664   1.00 27.32 ?  355 GLU A CA  1 
ATOM   2719 C C   . GLU A 1 391 ? -8.031  -26.856 3.368   1.00 31.36 ?  355 GLU A C   1 
ATOM   2720 O O   . GLU A 1 391 ? -9.143  -27.392 3.294   1.00 27.49 ?  355 GLU A O   1 
ATOM   2721 C CB  . GLU A 1 391 ? -7.873  -24.686 4.637   1.00 28.93 ?  355 GLU A CB  1 
ATOM   2722 C CG  . GLU A 1 391 ? -9.256  -24.299 5.125   1.00 34.96 ?  355 GLU A CG  1 
ATOM   2723 C CD  . GLU A 1 391 ? -9.826  -25.229 6.202   1.00 33.17 ?  355 GLU A CD  1 
ATOM   2724 O OE1 . GLU A 1 391 ? -9.326  -25.223 7.351   1.00 31.78 ?  355 GLU A OE1 1 
ATOM   2725 O OE2 . GLU A 1 391 ? -10.802 -25.947 5.876   1.00 35.06 ?  355 GLU A OE2 1 
ATOM   2726 N N   . HIS A 1 392 ? -7.180  -26.856 2.340   1.00 29.42 ?  356 HIS A N   1 
ATOM   2727 C CA  . HIS A 1 392 ? -7.583  -27.349 1.025   1.00 32.63 ?  356 HIS A CA  1 
ATOM   2728 C C   . HIS A 1 392 ? -6.674  -28.450 0.508   1.00 30.92 ?  356 HIS A C   1 
ATOM   2729 O O   . HIS A 1 392 ? -6.675  -28.727 -0.697  1.00 30.61 ?  356 HIS A O   1 
ATOM   2730 C CB  . HIS A 1 392 ? -7.635  -26.203 0.008   1.00 29.75 ?  356 HIS A CB  1 
ATOM   2731 C CG  . HIS A 1 392 ? -8.348  -24.999 0.521   1.00 29.77 ?  356 HIS A CG  1 
ATOM   2732 N ND1 . HIS A 1 392 ? -9.663  -25.041 0.933   1.00 29.55 ?  356 HIS A ND1 1 
ATOM   2733 C CD2 . HIS A 1 392 ? -7.926  -23.732 0.734   1.00 28.90 ?  356 HIS A CD2 1 
ATOM   2734 C CE1 . HIS A 1 392 ? -10.025 -23.848 1.368   1.00 25.83 ?  356 HIS A CE1 1 
ATOM   2735 N NE2 . HIS A 1 392 ? -8.989  -23.035 1.260   1.00 29.40 ?  356 HIS A NE2 1 
ATOM   2736 N N   . ALA A 1 393 ? -5.890  -29.075 1.380   1.00 30.18 ?  357 ALA A N   1 
ATOM   2737 C CA  . ALA A 1 393 ? -4.948  -30.075 0.906   1.00 31.93 ?  357 ALA A CA  1 
ATOM   2738 C C   . ALA A 1 393 ? -4.521  -30.954 2.066   1.00 30.82 ?  357 ALA A C   1 
ATOM   2739 O O   . ALA A 1 393 ? -4.436  -30.505 3.212   1.00 28.98 ?  357 ALA A O   1 
ATOM   2740 C CB  . ALA A 1 393 ? -3.719  -29.440 0.247   1.00 30.34 ?  357 ALA A CB  1 
ATOM   2741 N N   . SER A 1 394 ? -4.248  -32.211 1.739   1.00 30.67 ?  358 SER A N   1 
ATOM   2742 C CA  . SER A 1 394 ? -3.731  -33.193 2.678   1.00 30.06 ?  358 SER A CA  1 
ATOM   2743 C C   . SER A 1 394 ? -2.368  -33.628 2.180   1.00 32.42 ?  358 SER A C   1 
ATOM   2744 O O   . SER A 1 394 ? -2.254  -34.152 1.067   1.00 33.88 ?  358 SER A O   1 
ATOM   2745 C CB  . SER A 1 394 ? -4.667  -34.391 2.792   1.00 34.76 ?  358 SER A CB  1 
ATOM   2746 O OG  . SER A 1 394 ? -4.238  -35.228 3.853   1.00 38.18 ?  358 SER A OG  1 
ATOM   2747 N N   . VAL A 1 395 ? -1.340  -33.406 2.996   1.00 30.74 ?  359 VAL A N   1 
ATOM   2748 C CA  . VAL A 1 395 ? 0.041   -33.692 2.627   1.00 28.59 ?  359 VAL A CA  1 
ATOM   2749 C C   . VAL A 1 395 ? 0.470   -34.995 3.275   1.00 27.73 ?  359 VAL A C   1 
ATOM   2750 O O   . VAL A 1 395 ? 0.260   -35.195 4.477   1.00 27.58 ?  359 VAL A O   1 
ATOM   2751 C CB  . VAL A 1 395 ? 0.967   -32.545 3.063   1.00 30.25 ?  359 VAL A CB  1 
ATOM   2752 C CG1 . VAL A 1 395 ? 2.405   -32.869 2.702   1.00 26.74 ?  359 VAL A CG1 1 
ATOM   2753 C CG2 . VAL A 1 395 ? 0.490   -31.239 2.446   1.00 25.90 ?  359 VAL A CG2 1 
ATOM   2754 N N   . TRP A 1 396 ? 1.104   -35.863 2.499   1.00 31.99 ?  360 TRP A N   1 
ATOM   2755 C CA  . TRP A 1 396 ? 1.758   -37.052 3.026   1.00 32.13 ?  360 TRP A CA  1 
ATOM   2756 C C   . TRP A 1 396 ? 3.116   -37.180 2.371   1.00 26.11 ?  360 TRP A C   1 
ATOM   2757 O O   . TRP A 1 396 ? 3.231   -37.024 1.158   1.00 32.61 ?  360 TRP A O   1 
ATOM   2758 C CB  . TRP A 1 396 ? 0.940   -38.345 2.758   1.00 32.99 ?  360 TRP A CB  1 
ATOM   2759 C CG  . TRP A 1 396 ? 1.726   -39.604 3.028   1.00 35.48 ?  360 TRP A CG  1 
ATOM   2760 C CD1 . TRP A 1 396 ? 1.827   -40.275 4.220   1.00 37.60 ?  360 TRP A CD1 1 
ATOM   2761 C CD2 . TRP A 1 396 ? 2.541   -40.330 2.096   1.00 34.77 ?  360 TRP A CD2 1 
ATOM   2762 N NE1 . TRP A 1 396 ? 2.655   -41.370 4.082   1.00 35.18 ?  360 TRP A NE1 1 
ATOM   2763 C CE2 . TRP A 1 396 ? 3.100   -41.427 2.789   1.00 33.62 ?  360 TRP A CE2 1 
ATOM   2764 C CE3 . TRP A 1 396 ? 2.851   -40.159 0.745   1.00 36.75 ?  360 TRP A CE3 1 
ATOM   2765 C CZ2 . TRP A 1 396 ? 3.940   -42.344 2.175   1.00 37.33 ?  360 TRP A CZ2 1 
ATOM   2766 C CZ3 . TRP A 1 396 ? 3.687   -41.081 0.134   1.00 35.47 ?  360 TRP A CZ3 1 
ATOM   2767 C CH2 . TRP A 1 396 ? 4.222   -42.152 0.849   1.00 37.92 ?  360 TRP A CH2 1 
ATOM   2768 N N   . VAL A 1 397 ? 4.141   -37.499 3.156   1.00 30.41 ?  361 VAL A N   1 
ATOM   2769 C CA  . VAL A 1 397 ? 5.475   -37.671 2.591   1.00 30.65 ?  361 VAL A CA  1 
ATOM   2770 C C   . VAL A 1 397 ? 6.251   -38.681 3.429   1.00 32.59 ?  361 VAL A C   1 
ATOM   2771 O O   . VAL A 1 397 ? 6.153   -38.697 4.661   1.00 29.79 ?  361 VAL A O   1 
ATOM   2772 C CB  . VAL A 1 397 ? 6.214   -36.313 2.487   1.00 29.52 ?  361 VAL A CB  1 
ATOM   2773 C CG1 . VAL A 1 397 ? 6.523   -35.744 3.868   1.00 28.00 ?  361 VAL A CG1 1 
ATOM   2774 C CG2 . VAL A 1 397 ? 7.476   -36.453 1.666   1.00 31.47 ?  361 VAL A CG2 1 
ATOM   2775 N N   . ASN A 1 398 ? 7.012   -39.541 2.745   1.00 31.40 ?  362 ASN A N   1 
ATOM   2776 C CA  . ASN A 1 398 ? 8.005   -40.422 3.359   1.00 34.13 ?  362 ASN A CA  1 
ATOM   2777 C C   . ASN A 1 398 ? 9.373   -39.903 2.933   1.00 32.39 ?  362 ASN A C   1 
ATOM   2778 O O   . ASN A 1 398 ? 9.732   -40.006 1.758   1.00 32.30 ?  362 ASN A O   1 
ATOM   2779 C CB  . ASN A 1 398 ? 7.808   -41.879 2.915   1.00 33.50 ?  362 ASN A CB  1 
ATOM   2780 C CG  . ASN A 1 398 ? 8.755   -42.860 3.628   1.00 36.51 ?  362 ASN A CG  1 
ATOM   2781 O OD1 . ASN A 1 398 ? 9.928   -42.570 3.865   1.00 34.34 ?  362 ASN A OD1 1 
ATOM   2782 N ND2 . ASN A 1 398 ? 8.230   -44.023 3.984   1.00 37.79 ?  362 ASN A ND2 1 
ATOM   2783 N N   . THR A 1 399 ? 10.133  -39.339 3.872   1.00 32.26 ?  363 THR A N   1 
ATOM   2784 C CA  . THR A 1 399 ? 11.433  -38.787 3.510   1.00 34.73 ?  363 THR A CA  1 
ATOM   2785 C C   . THR A 1 399 ? 12.550  -39.825 3.544   1.00 39.80 ?  363 THR A C   1 
ATOM   2786 O O   . THR A 1 399 ? 13.700  -39.474 3.257   1.00 38.18 ?  363 THR A O   1 
ATOM   2787 C CB  . THR A 1 399 ? 11.808  -37.593 4.403   1.00 30.68 ?  363 THR A CB  1 
ATOM   2788 O OG1 . THR A 1 399 ? 11.780  -37.971 5.787   1.00 33.97 ?  363 THR A OG1 1 
ATOM   2789 C CG2 . THR A 1 399 ? 10.854  -36.415 4.155   1.00 28.92 ?  363 THR A CG2 1 
ATOM   2790 N N   . GLU A 1 400 ? 12.246  -41.083 3.891   1.00 36.42 ?  364 GLU A N   1 
ATOM   2791 C CA  . GLU A 1 400 ? 13.213  -42.164 3.713   1.00 37.53 ?  364 GLU A CA  1 
ATOM   2792 C C   . GLU A 1 400 ? 13.207  -42.657 2.278   1.00 39.73 ?  364 GLU A C   1 
ATOM   2793 O O   . GLU A 1 400 ? 14.261  -42.775 1.641   1.00 42.12 ?  364 GLU A O   1 
ATOM   2794 C CB  . GLU A 1 400 ? 12.905  -43.335 4.640   1.00 38.90 ?  364 GLU A CB  1 
ATOM   2795 C CG  . GLU A 1 400 ? 14.130  -44.142 5.025   1.00 42.14 ?  364 GLU A CG  1 
ATOM   2796 C CD  . GLU A 1 400 ? 13.912  -44.949 6.287   1.00 45.35 ?  364 GLU A CD  1 
ATOM   2797 O OE1 . GLU A 1 400 ? 14.758  -45.805 6.618   1.00 47.98 ?  364 GLU A OE1 1 
ATOM   2798 O OE2 . GLU A 1 400 ? 12.864  -44.749 6.936   1.00 52.72 ?  364 GLU A OE2 1 
ATOM   2799 N N   . THR A 1 401 ? 12.026  -42.954 1.759   1.00 36.89 ?  365 THR A N   1 
ATOM   2800 C CA  . THR A 1 401 ? 11.890  -43.479 0.414   1.00 38.06 ?  365 THR A CA  1 
ATOM   2801 C C   . THR A 1 401 ? 11.781  -42.388 -0.639  1.00 41.37 ?  365 THR A C   1 
ATOM   2802 O O   . THR A 1 401 ? 11.947  -42.682 -1.829  1.00 42.52 ?  365 THR A O   1 
ATOM   2803 C CB  . THR A 1 401 ? 10.671  -44.410 0.349   1.00 37.14 ?  365 THR A CB  1 
ATOM   2804 O OG1 . THR A 1 401 ? 9.469   -43.637 0.262   1.00 40.36 ?  365 THR A OG1 1 
ATOM   2805 C CG2 . THR A 1 401 ? 10.611  -45.264 1.603   1.00 38.18 ?  365 THR A CG2 1 
ATOM   2806 N N   . GLY A 1 402 ? 11.521  -41.146 -0.237  1.00 36.99 ?  366 GLY A N   1 
ATOM   2807 C CA  . GLY A 1 402 ? 11.399  -40.066 -1.202  1.00 34.31 ?  366 GLY A CA  1 
ATOM   2808 C C   . GLY A 1 402 ? 10.129  -40.096 -2.021  1.00 37.95 ?  366 GLY A C   1 
ATOM   2809 O O   . GLY A 1 402 ? 10.172  -39.856 -3.236  1.00 41.54 ?  366 GLY A O   1 
ATOM   2810 N N   . ASN A 1 403 ? 8.993   -40.378 -1.387  1.00 36.39 ?  367 ASN A N   1 
ATOM   2811 C CA  . ASN A 1 403 ? 7.703   -40.412 -2.060  1.00 38.65 ?  367 ASN A CA  1 
ATOM   2812 C C   . ASN A 1 403 ? 6.729   -39.519 -1.312  1.00 34.75 ?  367 ASN A C   1 
ATOM   2813 O O   . ASN A 1 403 ? 6.812   -39.371 -0.088  1.00 34.64 ?  367 ASN A O   1 
ATOM   2814 C CB  . ASN A 1 403 ? 7.144   -41.844 -2.147  1.00 39.13 ?  367 ASN A CB  1 
ATOM   2815 C CG  . ASN A 1 403 ? 8.165   -42.837 -2.683  1.00 42.76 ?  367 ASN A CG  1 
ATOM   2816 O OD1 . ASN A 1 403 ? 8.581   -43.753 -1.979  1.00 41.92 ?  367 ASN A OD1 1 
ATOM   2817 N ND2 . ASN A 1 403 ? 8.569   -42.657 -3.935  1.00 46.04 ?  367 ASN A ND2 1 
ATOM   2818 N N   . ALA A 1 404 ? 5.807   -38.920 -2.056  1.00 29.97 ?  368 ALA A N   1 
ATOM   2819 C CA  . ALA A 1 404 ? 4.872   -38.003 -1.435  1.00 33.00 ?  368 ALA A CA  1 
ATOM   2820 C C   . ALA A 1 404 ? 3.559   -38.013 -2.200  1.00 35.44 ?  368 ALA A C   1 
ATOM   2821 O O   . ALA A 1 404 ? 3.500   -38.350 -3.385  1.00 41.05 ?  368 ALA A O   1 
ATOM   2822 C CB  . ALA A 1 404 ? 5.441   -36.579 -1.365  1.00 32.40 ?  368 ALA A CB  1 
ATOM   2823 N N   . LYS A 1 405 ? 2.505   -37.621 -1.499  1.00 32.47 ?  369 LYS A N   1 
ATOM   2824 C CA  . LYS A 1 405 ? 1.199   -37.428 -2.101  1.00 38.12 ?  369 LYS A CA  1 
ATOM   2825 C C   . LYS A 1 405 ? 0.574   -36.205 -1.457  1.00 36.65 ?  369 LYS A C   1 
ATOM   2826 O O   . LYS A 1 405 ? 0.390   -36.171 -0.237  1.00 33.01 ?  369 LYS A O   1 
ATOM   2827 C CB  . LYS A 1 405 ? 0.303   -38.658 -1.906  1.00 34.99 ?  369 LYS A CB  1 
ATOM   2828 C CG  . LYS A 1 405 ? -0.736  -38.889 -3.010  1.00 41.36 ?  369 LYS A CG  1 
ATOM   2829 C CD  . LYS A 1 405 ? -0.178  -38.567 -4.400  1.00 48.82 ?  369 LYS A CD  1 
ATOM   2830 C CE  . LYS A 1 405 ? 0.767   -39.663 -4.924  1.00 48.01 ?  369 LYS A CE  1 
ATOM   2831 N NZ  . LYS A 1 405 ? 1.546   -39.220 -6.138  1.00 47.12 ?  369 LYS A NZ  1 
ATOM   2832 N N   . ILE A 1 406 ? 0.262   -35.206 -2.268  1.00 34.83 ?  370 ILE A N   1 
ATOM   2833 C CA  . ILE A 1 406 ? -0.576  -34.094 -1.850  1.00 35.60 ?  370 ILE A CA  1 
ATOM   2834 C C   . ILE A 1 406 ? -1.952  -34.311 -2.455  1.00 34.29 ?  370 ILE A C   1 
ATOM   2835 O O   . ILE A 1 406 ? -2.104  -34.314 -3.683  1.00 38.94 ?  370 ILE A O   1 
ATOM   2836 C CB  . ILE A 1 406 ? 0.007   -32.741 -2.282  1.00 33.59 ?  370 ILE A CB  1 
ATOM   2837 C CG1 . ILE A 1 406 ? 1.406   -32.548 -1.702  1.00 29.64 ?  370 ILE A CG1 1 
ATOM   2838 C CG2 . ILE A 1 406 ? -0.920  -31.634 -1.838  1.00 32.22 ?  370 ILE A CG2 1 
ATOM   2839 C CD1 . ILE A 1 406 ? 2.200   -31.409 -2.350  1.00 31.52 ?  370 ILE A CD1 1 
ATOM   2840 N N   . THR A 1 407 ? -2.952  -34.495 -1.601  1.00 32.64 ?  371 THR A N   1 
ATOM   2841 C CA  . THR A 1 407 ? -4.336  -34.683 -2.024  1.00 35.66 ?  371 THR A CA  1 
ATOM   2842 C C   . THR A 1 407 ? -5.022  -33.326 -1.964  1.00 34.58 ?  371 THR A C   1 
ATOM   2843 O O   . THR A 1 407 ? -5.377  -32.848 -0.885  1.00 35.60 ?  371 THR A O   1 
ATOM   2844 C CB  . THR A 1 407 ? -5.054  -35.697 -1.137  1.00 35.46 ?  371 THR A CB  1 
ATOM   2845 O OG1 . THR A 1 407 ? -4.432  -36.976 -1.279  1.00 39.51 ?  371 THR A OG1 1 
ATOM   2846 C CG2 . THR A 1 407 ? -6.539  -35.797 -1.516  1.00 33.97 ?  371 THR A CG2 1 
ATOM   2847 N N   . TRP A 1 408 ? -5.224  -32.714 -3.126  1.00 33.17 ?  372 TRP A N   1 
ATOM   2848 C CA  . TRP A 1 408 ? -5.834  -31.394 -3.186  1.00 33.54 ?  372 TRP A CA  1 
ATOM   2849 C C   . TRP A 1 408 ? -7.340  -31.517 -3.095  1.00 36.90 ?  372 TRP A C   1 
ATOM   2850 O O   . TRP A 1 408 ? -7.950  -32.281 -3.848  1.00 42.11 ?  372 TRP A O   1 
ATOM   2851 C CB  . TRP A 1 408 ? -5.439  -30.694 -4.479  1.00 38.04 ?  372 TRP A CB  1 
ATOM   2852 C CG  . TRP A 1 408 ? -3.972  -30.516 -4.580  1.00 38.35 ?  372 TRP A CG  1 
ATOM   2853 C CD1 . TRP A 1 408 ? -3.098  -31.306 -5.261  1.00 35.21 ?  372 TRP A CD1 1 
ATOM   2854 C CD2 . TRP A 1 408 ? -3.193  -29.489 -3.958  1.00 37.19 ?  372 TRP A CD2 1 
ATOM   2855 N NE1 . TRP A 1 408 ? -1.819  -30.830 -5.109  1.00 36.43 ?  372 TRP A NE1 1 
ATOM   2856 C CE2 . TRP A 1 408 ? -1.853  -29.710 -4.315  1.00 37.64 ?  372 TRP A CE2 1 
ATOM   2857 C CE3 . TRP A 1 408 ? -3.501  -28.402 -3.140  1.00 37.01 ?  372 TRP A CE3 1 
ATOM   2858 C CZ2 . TRP A 1 408 ? -0.820  -28.883 -3.879  1.00 35.92 ?  372 TRP A CZ2 1 
ATOM   2859 C CZ3 . TRP A 1 408 ? -2.476  -27.584 -2.712  1.00 33.37 ?  372 TRP A CZ3 1 
ATOM   2860 C CH2 . TRP A 1 408 ? -1.155  -27.829 -3.078  1.00 33.46 ?  372 TRP A CH2 1 
ATOM   2861 N N   . ARG A 1 409 ? -7.937  -30.774 -2.173  1.00 30.78 ?  373 ARG A N   1 
ATOM   2862 C CA  . ARG A 1 409 ? -9.370  -30.875 -1.952  1.00 36.20 ?  373 ARG A CA  1 
ATOM   2863 C C   . ARG A 1 409 ? -10.087 -29.594 -2.403  1.00 39.25 ?  373 ARG A C   1 
ATOM   2864 O O   . ARG A 1 409 ? -9.494  -28.518 -2.549  1.00 36.15 ?  373 ARG A O   1 
ATOM   2865 C CB  . ARG A 1 409 ? -9.660  -31.180 -0.473  1.00 37.81 ?  373 ARG A CB  1 
ATOM   2866 C CG  . ARG A 1 409 ? -10.127 -29.989 0.338   1.00 38.92 ?  373 ARG A CG  1 
ATOM   2867 C CD  . ARG A 1 409 ? -10.325 -30.274 1.842   1.00 39.88 ?  373 ARG A CD  1 
ATOM   2868 N NE  . ARG A 1 409 ? -9.074  -30.366 2.593   1.00 48.75 ?  373 ARG A NE  1 
ATOM   2869 C CZ  . ARG A 1 409 ? -8.390  -31.485 2.824   1.00 44.57 ?  373 ARG A CZ  1 
ATOM   2870 N NH1 . ARG A 1 409 ? -8.827  -32.666 2.408   1.00 42.91 ?  373 ARG A NH1 1 
ATOM   2871 N NH2 . ARG A 1 409 ? -7.251  -31.421 3.525   1.00 40.18 ?  373 ARG A NH2 1 
ATOM   2872 O OXT . ARG A 1 409 ? -11.295 -29.600 -2.648  1.00 40.92 ?  373 ARG A OXT 1 
HETATM 2873 C C5  . X6Y B 2 .   ? 23.119  -19.629 -4.606  1.00 40.75 ?  1   X6Y B C5  1 
HETATM 2874 C C6  . X6Y B 2 .   ? 22.107  -18.567 -4.381  1.00 33.21 ?  1   X6Y B C6  1 
HETATM 2875 C C2  . X6Y B 2 .   ? 25.925  -19.655 -5.125  1.00 47.77 ?  1   X6Y B C2  1 
HETATM 2876 C C4  . X6Y B 2 .   ? 23.721  -19.439 -6.002  1.00 42.36 ?  1   X6Y B C4  1 
HETATM 2877 C C3  . X6Y B 2 .   ? 24.978  -20.178 -6.148  1.00 46.31 ?  1   X6Y B C3  1 
HETATM 2878 C C1  . X6Y B 2 .   ? 25.418  -20.140 -3.771  1.00 44.82 ?  1   X6Y B C1  1 
HETATM 2879 O O5  . X6Y B 2 .   ? 24.108  -19.559 -3.479  1.00 35.62 ?  1   X6Y B O5  1 
HETATM 2880 O O4  . X6Y B 2 .   ? 23.981  -18.037 -6.200  1.00 40.06 ?  1   X6Y B O4  1 
HETATM 2881 O O1  . X6Y B 2 .   ? 25.299  -21.504 -3.796  1.00 44.21 ?  1   X6Y B O1  1 
HETATM 2882 O O3  . X6Y B 2 .   ? 25.531  -20.005 -7.484  1.00 47.21 ?  1   X6Y B O3  1 
HETATM 2883 S S1  . X6Y B 2 .   ? 28.445  -19.039 -4.862  1.00 69.62 ?  1   X6Y B S1  1 
HETATM 2884 O O6  . X6Y B 2 .   ? 29.799  -19.616 -5.153  1.00 49.23 ?  1   X6Y B O6  1 
HETATM 2885 O O7  . X6Y B 2 .   ? 28.252  -17.689 -5.493  1.00 42.09 -1 1   X6Y B O7  1 
HETATM 2886 O O8  . X6Y B 2 .   ? 28.485  -18.926 -3.358  1.00 62.86 ?  1   X6Y B O8  1 
HETATM 2887 O O2  . X6Y B 2 .   ? 27.267  -20.090 -5.366  1.00 60.69 ?  1   X6Y B O2  1 
HETATM 2888 C C5  . X6Y B 2 .   ? 25.902  -22.843 -8.154  1.00 55.37 ?  2   X6Y B C5  1 
HETATM 2889 C C6  . X6Y B 2 .   ? 25.561  -24.282 -8.047  1.00 49.70 ?  2   X6Y B C6  1 
HETATM 2890 C C2  . X6Y B 2 .   ? 25.360  -20.539 -9.784  1.00 56.68 ?  2   X6Y B C2  1 
HETATM 2891 C C4  . X6Y B 2 .   ? 26.685  -22.600 -9.452  1.00 57.25 ?  2   X6Y B C4  1 
HETATM 2892 C C3  . X6Y B 2 .   ? 26.706  -21.177 -9.853  1.00 60.22 ?  2   X6Y B C3  1 
HETATM 2893 C C1  . X6Y B 2 .   ? 24.744  -20.668 -8.397  1.00 52.37 ?  2   X6Y B C1  1 
HETATM 2894 O O5  . X6Y B 2 .   ? 24.617  -22.080 -8.047  1.00 52.15 ?  2   X6Y B O5  1 
HETATM 2895 O O4  . X6Y B 2 .   ? 26.105  -23.386 -10.511 1.00 57.21 ?  2   X6Y B O4  1 
HETATM 2896 O O3  . X6Y B 2 .   ? 27.163  -21.069 -11.231 1.00 62.19 ?  2   X6Y B O3  1 
HETATM 2897 S S1  . X6Y B 2 .   ? 24.578  -18.697 -11.370 1.00 54.74 ?  2   X6Y B S1  1 
HETATM 2898 O O6  . X6Y B 2 .   ? 25.291  -18.968 -12.662 1.00 57.96 ?  2   X6Y B O6  1 
HETATM 2899 O O7  . X6Y B 2 .   ? 24.231  -17.249 -11.216 1.00 46.49 -1 2   X6Y B O7  1 
HETATM 2900 O O8  . X6Y B 2 .   ? 23.358  -19.559 -11.518 1.00 50.21 ?  2   X6Y B O8  1 
HETATM 2901 O O2  . X6Y B 2 .   ? 25.493  -19.160 -10.095 1.00 56.72 ?  2   X6Y B O2  1 
HETATM 2902 C C5  . X2Y B 2 .   ? 28.606  -18.571 -11.569 1.00 61.39 ?  3   X2Y B C5  1 
HETATM 2903 C C4  . X2Y B 2 .   ? 29.203  -18.804 -12.945 1.00 67.58 ?  3   X2Y B C4  1 
HETATM 2904 C C3  . X2Y B 2 .   ? 28.606  -19.997 -13.556 1.00 67.55 ?  3   X2Y B C3  1 
HETATM 2905 C C2  . X2Y B 2 .   ? 28.948  -21.169 -12.735 1.00 71.26 ?  3   X2Y B C2  1 
HETATM 2906 C C1  . X2Y B 2 .   ? 28.517  -20.995 -11.277 1.00 64.61 ?  3   X2Y B C1  1 
HETATM 2907 O O5  . X2Y B 2 .   ? 28.940  -19.691 -10.695 1.00 61.68 ?  3   X2Y B O5  1 
HETATM 2908 C C6  . X2Y B 2 .   ? 29.169  -17.306 -11.015 1.00 51.85 ?  3   X2Y B C6  1 
HETATM 2909 O O3  . X2Y B 2 .   ? 29.210  -20.090 -14.869 1.00 70.11 ?  3   X2Y B O3  1 
HETATM 2910 S S1  . X2Y B 2 .   ? 29.196  -23.727 -13.050 1.00 78.38 ?  3   X2Y B S1  1 
HETATM 2911 O O6  . X2Y B 2 .   ? 30.631  -23.471 -13.414 1.00 78.58 ?  3   X2Y B O6  1 
HETATM 2912 O O7  . X2Y B 2 .   ? 29.086  -24.230 -11.640 1.00 74.95 -1 3   X2Y B O7  1 
HETATM 2913 O O8  . X2Y B 2 .   ? 28.786  -24.778 -14.037 1.00 72.34 ?  3   X2Y B O8  1 
HETATM 2914 O O2  . X2Y B 2 .   ? 28.309  -22.352 -13.247 1.00 76.13 ?  3   X2Y B O2  1 
HETATM 2915 S S2  . X2Y B 2 .   ? 31.652  -18.240 -13.705 1.00 72.86 ?  3   X2Y B S2  1 
HETATM 2916 O O9  . X2Y B 2 .   ? 31.242  -18.183 -15.147 1.00 73.68 ?  3   X2Y B O9  1 
HETATM 2917 O O10 . X2Y B 2 .   ? 33.011  -18.866 -13.563 1.00 74.76 -1 3   X2Y B O10 1 
HETATM 2918 O O11 . X2Y B 2 .   ? 31.686  -16.778 -13.380 1.00 60.64 ?  3   X2Y B O11 1 
HETATM 2919 O O4  . X2Y B 2 .   ? 30.587  -19.073 -12.773 1.00 64.03 ?  3   X2Y B O4  1 
HETATM 2920 C C1  . FUC B 2 .   ? 28.386  -20.673 -15.782 1.00 72.29 ?  4   FUC B C1  1 
HETATM 2921 C C2  . FUC B 2 .   ? 28.379  -19.802 -17.033 1.00 74.29 ?  4   FUC B C2  1 
HETATM 2922 C C3  . FUC B 2 .   ? 29.743  -19.619 -17.591 1.00 74.45 ?  4   FUC B C3  1 
HETATM 2923 C C4  . FUC B 2 .   ? 30.524  -20.872 -17.684 1.00 75.53 ?  4   FUC B C4  1 
HETATM 2924 C C5  . FUC B 2 .   ? 30.375  -21.768 -16.450 1.00 76.01 ?  4   FUC B C5  1 
HETATM 2925 C C6  . FUC B 2 .   ? 30.999  -23.088 -16.713 1.00 74.19 ?  4   FUC B C6  1 
HETATM 2926 O O2  . FUC B 2 .   ? 27.873  -18.512 -16.697 1.00 72.75 ?  4   FUC B O2  1 
HETATM 2927 O O3  . FUC B 2 .   ? 29.590  -19.059 -18.934 1.00 75.47 ?  4   FUC B O3  1 
HETATM 2928 O O4  . FUC B 2 .   ? 30.086  -21.592 -18.857 1.00 73.64 ?  4   FUC B O4  1 
HETATM 2929 O O5  . FUC B 2 .   ? 28.946  -21.973 -16.085 1.00 75.98 ?  4   FUC B O5  1 
HETATM 2930 O O   . HOH C 3 .   ? -2.504  -11.780 4.911   1.00 31.51 ?  401 HOH A O   1 
HETATM 2931 O O   . HOH C 3 .   ? 32.120  -10.039 -15.493 1.00 41.57 ?  402 HOH A O   1 
HETATM 2932 O O   . HOH C 3 .   ? 25.377  6.696   -6.890  1.00 32.69 ?  403 HOH A O   1 
HETATM 2933 O O   . HOH C 3 .   ? -2.399  -36.428 4.635   1.00 35.02 ?  404 HOH A O   1 
HETATM 2934 O O   . HOH C 3 .   ? 46.176  -15.268 -6.986  1.00 41.45 ?  405 HOH A O   1 
HETATM 2935 O O   . HOH C 3 .   ? -2.925  -35.000 -5.773  1.00 41.57 ?  406 HOH A O   1 
HETATM 2936 O O   . HOH C 3 .   ? 32.975  -0.284  10.787  1.00 34.42 ?  407 HOH A O   1 
HETATM 2937 O O   . HOH C 3 .   ? 0.571   -17.647 -0.737  1.00 25.72 ?  408 HOH A O   1 
HETATM 2938 O O   . HOH C 3 .   ? 4.937   -30.313 -11.729 1.00 39.20 ?  409 HOH A O   1 
HETATM 2939 O O   . HOH C 3 .   ? -1.354  -31.097 -9.873  1.00 46.31 ?  410 HOH A O   1 
HETATM 2940 O O   . HOH C 3 .   ? 14.676  -19.543 -12.256 1.00 29.26 ?  411 HOH A O   1 
HETATM 2941 O O   . HOH C 3 .   ? 1.274   -19.964 -5.140  1.00 24.70 ?  412 HOH A O   1 
HETATM 2942 O O   . HOH C 3 .   ? 2.931   -7.372  -23.529 1.00 44.91 ?  413 HOH A O   1 
HETATM 2943 O O   . HOH C 3 .   ? 9.861   -30.377 13.224  1.00 30.00 ?  414 HOH A O   1 
HETATM 2944 O O   . HOH C 3 .   ? 8.985   -34.236 14.740  1.00 28.48 ?  415 HOH A O   1 
HETATM 2945 O O   . HOH C 3 .   ? 15.351  -9.560  -23.032 1.00 32.52 ?  416 HOH A O   1 
HETATM 2946 O O   . HOH C 3 .   ? 20.284  -26.516 11.037  1.00 35.22 ?  417 HOH A O   1 
HETATM 2947 O O   . HOH C 3 .   ? 8.348   -37.531 -7.142  1.00 43.79 ?  418 HOH A O   1 
HETATM 2948 O O   . HOH C 3 .   ? 17.262  -34.235 11.905  1.00 35.66 ?  419 HOH A O   1 
HETATM 2949 O O   . HOH C 3 .   ? 38.116  -12.002 -10.692 1.00 31.16 ?  420 HOH A O   1 
HETATM 2950 O O   . HOH C 3 .   ? 9.393   -7.723  -25.433 1.00 38.18 ?  421 HOH A O   1 
HETATM 2951 O O   . HOH C 3 .   ? 12.438  -36.176 7.378   1.00 26.59 ?  422 HOH A O   1 
HETATM 2952 O O   . HOH C 3 .   ? 4.638   -36.972 -6.194  1.00 40.36 ?  423 HOH A O   1 
HETATM 2953 O O   . HOH C 3 .   ? 19.144  -39.034 -8.171  1.00 44.85 ?  424 HOH A O   1 
HETATM 2954 O O   . HOH C 3 .   ? 45.914  -19.908 -4.322  1.00 39.70 ?  425 HOH A O   1 
HETATM 2955 O O   . HOH C 3 .   ? 9.170   -0.088  9.925   1.00 39.10 ?  426 HOH A O   1 
HETATM 2956 O O   . HOH C 3 .   ? 8.290   -10.202 12.795  1.00 28.24 ?  427 HOH A O   1 
HETATM 2957 O O   . HOH C 3 .   ? 10.972  -3.970  2.863   1.00 29.04 ?  428 HOH A O   1 
HETATM 2958 O O   . HOH C 3 .   ? -3.170  -22.353 10.840  1.00 26.60 ?  429 HOH A O   1 
HETATM 2959 O O   . HOH C 3 .   ? 17.806  -21.336 6.398   1.00 35.49 ?  430 HOH A O   1 
HETATM 2960 O O   . HOH C 3 .   ? 20.730  -8.258  -7.300  1.00 18.88 ?  431 HOH A O   1 
HETATM 2961 O O   . HOH C 3 .   ? 15.806  -20.147 -10.028 1.00 23.73 ?  432 HOH A O   1 
HETATM 2962 O O   . HOH C 3 .   ? 12.645  -45.824 11.826  1.00 35.25 ?  433 HOH A O   1 
HETATM 2963 O O   . HOH C 3 .   ? 30.559  -18.256 10.241  1.00 24.54 ?  434 HOH A O   1 
HETATM 2964 O O   . HOH C 3 .   ? 12.724  -1.172  -15.329 1.00 30.85 ?  435 HOH A O   1 
HETATM 2965 O O   . HOH C 3 .   ? 23.999  -9.908  -23.859 1.00 37.33 ?  436 HOH A O   1 
HETATM 2966 O O   . HOH C 3 .   ? -7.074  -35.421 5.089   1.00 43.30 ?  437 HOH A O   1 
HETATM 2967 O O   . HOH C 3 .   ? -4.360  -10.979 11.510  1.00 48.84 ?  438 HOH A O   1 
HETATM 2968 O O   . HOH C 3 .   ? 16.371  -25.303 15.018  1.00 31.69 ?  439 HOH A O   1 
HETATM 2969 O O   . HOH C 3 .   ? 33.459  -21.454 11.986  1.00 36.78 ?  440 HOH A O   1 
HETATM 2970 O O   . HOH C 3 .   ? 41.586  -13.654 -2.069  1.00 24.75 ?  441 HOH A O   1 
HETATM 2971 O O   . HOH C 3 .   ? 31.484  0.460   -2.802  1.00 29.44 ?  442 HOH A O   1 
HETATM 2972 O O   . HOH C 3 .   ? 19.148  -26.371 2.819   1.00 24.17 ?  443 HOH A O   1 
HETATM 2973 O O   . HOH C 3 .   ? 18.292  -27.798 8.323   1.00 30.96 ?  444 HOH A O   1 
HETATM 2974 O O   . HOH C 3 .   ? 15.386  -33.363 -19.647 1.00 43.61 ?  445 HOH A O   1 
HETATM 2975 O O   . HOH C 3 .   ? 36.252  -5.183  -14.021 1.00 39.54 ?  446 HOH A O   1 
HETATM 2976 O O   . HOH C 3 .   ? 14.956  0.148   -9.402  1.00 23.82 ?  447 HOH A O   1 
HETATM 2977 O O   . HOH C 3 .   ? 9.535   -21.644 -9.487  1.00 30.18 ?  448 HOH A O   1 
HETATM 2978 O O   . HOH C 3 .   ? 8.927   -2.221  -0.397  1.00 35.82 ?  449 HOH A O   1 
HETATM 2979 O O   . HOH C 3 .   ? 4.507   -31.670 14.840  1.00 29.89 ?  450 HOH A O   1 
HETATM 2980 O O   . HOH C 3 .   ? 14.656  -33.261 15.697  1.00 34.36 ?  451 HOH A O   1 
HETATM 2981 O O   . HOH C 3 .   ? 18.286  -7.574  -22.282 1.00 31.67 ?  452 HOH A O   1 
HETATM 2982 O O   . HOH C 3 .   ? 11.127  -38.417 -11.294 1.00 50.64 ?  453 HOH A O   1 
HETATM 2983 O O   . HOH C 3 .   ? 10.426  -16.628 20.199  1.00 31.66 ?  454 HOH A O   1 
HETATM 2984 O O   . HOH C 3 .   ? 30.107  2.099   10.389  1.00 36.08 ?  455 HOH A O   1 
HETATM 2985 O O   . HOH C 3 .   ? 4.156   -14.021 18.845  1.00 37.84 ?  456 HOH A O   1 
HETATM 2986 O O   . HOH C 3 .   ? 6.950   -8.393  14.983  1.00 42.11 ?  457 HOH A O   1 
HETATM 2987 O O   . HOH C 3 .   ? 37.096  0.069   5.417   1.00 26.59 ?  458 HOH A O   1 
HETATM 2988 O O   . HOH C 3 .   ? 29.503  -8.289  -7.848  1.00 23.96 ?  459 HOH A O   1 
HETATM 2989 O O   . HOH C 3 .   ? -3.956  -17.433 4.105   1.00 29.46 ?  460 HOH A O   1 
HETATM 2990 O O   . HOH C 3 .   ? 17.817  -28.990 -3.899  1.00 36.69 ?  461 HOH A O   1 
HETATM 2991 O O   . HOH C 3 .   ? 14.664  -35.567 -0.157  1.00 33.82 ?  462 HOH A O   1 
HETATM 2992 O O   . HOH C 3 .   ? 30.660  -10.262 -3.481  1.00 20.82 ?  463 HOH A O   1 
HETATM 2993 O O   . HOH C 3 .   ? 12.529  0.904   -5.953  1.00 31.15 ?  464 HOH A O   1 
HETATM 2994 O O   . HOH C 3 .   ? -0.234  -24.510 -3.909  1.00 25.05 ?  465 HOH A O   1 
HETATM 2995 O O   . HOH C 3 .   ? 42.548  -9.102  5.555   1.00 29.83 ?  466 HOH A O   1 
HETATM 2996 O O   . HOH C 3 .   ? 6.682   0.374   -4.670  1.00 39.49 ?  467 HOH A O   1 
HETATM 2997 O O   . HOH C 3 .   ? 47.446  -3.646  -0.423  1.00 37.32 ?  468 HOH A O   1 
HETATM 2998 O O   . HOH C 3 .   ? 24.646  -8.116  -7.268  1.00 17.67 ?  469 HOH A O   1 
HETATM 2999 O O   . HOH C 3 .   ? 8.398   -26.245 10.963  1.00 25.00 ?  470 HOH A O   1 
HETATM 3000 O O   . HOH C 3 .   ? 22.670  -13.494 -12.595 1.00 24.09 ?  471 HOH A O   1 
HETATM 3001 O O   . HOH C 3 .   ? 33.189  -13.574 4.311   1.00 22.70 ?  472 HOH A O   1 
HETATM 3002 O O   . HOH C 3 .   ? 7.383   -21.204 -11.534 1.00 33.38 ?  473 HOH A O   1 
HETATM 3003 O O   . HOH C 3 .   ? 18.625  -28.702 4.392   1.00 31.39 ?  474 HOH A O   1 
HETATM 3004 O O   . HOH C 3 .   ? 12.669  -20.869 -16.196 1.00 32.36 ?  475 HOH A O   1 
HETATM 3005 O O   . HOH C 3 .   ? 45.213  -9.183  1.188   1.00 44.45 ?  476 HOH A O   1 
HETATM 3006 O O   . HOH C 3 .   ? 4.627   -40.237 16.419  1.00 37.99 ?  477 HOH A O   1 
HETATM 3007 O O   . HOH C 3 .   ? 20.410  -23.730 -14.626 1.00 37.42 ?  478 HOH A O   1 
HETATM 3008 O O   . HOH C 3 .   ? 12.618  -6.229  -17.403 1.00 23.00 ?  479 HOH A O   1 
HETATM 3009 O O   . HOH C 3 .   ? 36.040  -2.690  -7.160  1.00 25.23 ?  480 HOH A O   1 
HETATM 3010 O O   . HOH C 3 .   ? 12.174  -20.917 19.659  1.00 40.11 ?  481 HOH A O   1 
HETATM 3011 O O   . HOH C 3 .   ? 10.214  -20.430 9.069   1.00 23.02 ?  482 HOH A O   1 
HETATM 3012 O O   . HOH C 3 .   ? 20.652  -24.745 4.578   1.00 28.30 ?  483 HOH A O   1 
HETATM 3013 O O   . HOH C 3 .   ? 15.693  -35.740 -2.763  1.00 38.62 ?  484 HOH A O   1 
HETATM 3014 O O   . HOH C 3 .   ? 5.477   -8.452  -1.188  1.00 38.95 ?  485 HOH A O   1 
HETATM 3015 O O   . HOH C 3 .   ? -3.067  -34.767 14.939  1.00 34.20 ?  486 HOH A O   1 
HETATM 3016 O O   . HOH C 3 .   ? 35.864  -14.024 5.076   1.00 24.95 ?  487 HOH A O   1 
HETATM 3017 O O   . HOH C 3 .   ? 6.667   -41.497 11.195  1.00 36.63 ?  488 HOH A O   1 
HETATM 3018 O O   . HOH C 3 .   ? 3.609   -13.629 -0.725  1.00 28.98 ?  489 HOH A O   1 
HETATM 3019 O O   . HOH C 3 .   ? 5.126   -14.494 -2.615  1.00 27.29 ?  490 HOH A O   1 
HETATM 3020 O O   . HOH C 3 .   ? -4.347  -15.957 18.851  1.00 53.63 ?  491 HOH A O   1 
HETATM 3021 O O   . HOH C 3 .   ? 26.092  -22.341 -0.561  1.00 31.76 ?  492 HOH A O   1 
HETATM 3022 O O   . HOH C 3 .   ? -2.158  -25.116 -11.354 1.00 40.64 ?  493 HOH A O   1 
HETATM 3023 O O   . HOH C 3 .   ? 29.429  2.189   -8.687  1.00 33.19 ?  494 HOH A O   1 
HETATM 3024 O O   . HOH C 3 .   ? 14.002  -8.201  -26.628 1.00 36.45 ?  495 HOH A O   1 
HETATM 3025 O O   . HOH C 3 .   ? 8.781   -18.057 9.249   1.00 18.09 ?  496 HOH A O   1 
HETATM 3026 O O   . HOH C 3 .   ? 21.685  -16.961 17.062  1.00 34.15 ?  497 HOH A O   1 
HETATM 3027 O O   . HOH C 3 .   ? 26.806  -16.568 19.754  1.00 44.92 ?  498 HOH A O   1 
HETATM 3028 O O   . HOH C 3 .   ? 14.091  -23.477 -19.253 1.00 38.09 ?  499 HOH A O   1 
HETATM 3029 O O   . HOH C 3 .   ? 22.710  -8.291  -9.406  1.00 15.66 ?  500 HOH A O   1 
HETATM 3030 O O   . HOH C 3 .   ? 42.770  -3.814  5.419   1.00 27.49 ?  501 HOH A O   1 
HETATM 3031 O O   . HOH C 3 .   ? 27.920  -16.473 12.822  1.00 29.50 ?  502 HOH A O   1 
HETATM 3032 O O   . HOH C 3 .   ? 0.126   -12.830 11.154  1.00 36.21 ?  503 HOH A O   1 
HETATM 3033 O O   . HOH C 3 .   ? 4.812   -33.401 -9.397  1.00 37.15 ?  504 HOH A O   1 
HETATM 3034 O O   . HOH C 3 .   ? 1.479   -39.079 14.848  1.00 37.67 ?  505 HOH A O   1 
HETATM 3035 O O   . HOH C 3 .   ? 16.394  -32.597 13.902  1.00 38.14 ?  506 HOH A O   1 
HETATM 3036 O O   . HOH C 3 .   ? 20.784  0.817   1.686   1.00 22.25 ?  507 HOH A O   1 
HETATM 3037 O O   . HOH C 3 .   ? 17.954  -2.674  7.619   1.00 43.58 ?  508 HOH A O   1 
HETATM 3038 O O   . HOH C 3 .   ? 37.310  -11.444 -7.478  1.00 26.93 ?  509 HOH A O   1 
HETATM 3039 O O   . HOH C 3 .   ? 25.833  1.779   -9.945  1.00 29.05 ?  510 HOH A O   1 
HETATM 3040 O O   . HOH C 3 .   ? 14.294  -38.378 -3.046  1.00 40.21 ?  511 HOH A O   1 
HETATM 3041 O O   . HOH C 3 .   ? 15.641  -23.798 -7.696  1.00 27.64 ?  512 HOH A O   1 
HETATM 3042 O O   . HOH C 3 .   ? -0.011  -25.287 11.848  1.00 28.60 ?  513 HOH A O   1 
HETATM 3043 O O   . HOH C 3 .   ? -5.789  -19.146 2.538   1.00 26.02 ?  514 HOH A O   1 
HETATM 3044 O O   . HOH C 3 .   ? 33.036  -4.608  12.341  1.00 28.66 ?  515 HOH A O   1 
HETATM 3045 O O   . HOH C 3 .   ? -2.823  -33.724 11.339  1.00 37.08 ?  516 HOH A O   1 
HETATM 3046 O O   . HOH C 3 .   ? 21.779  -36.974 6.844   1.00 42.22 ?  517 HOH A O   1 
HETATM 3047 O O   . HOH C 3 .   ? 6.270   -15.727 15.882  1.00 29.91 ?  518 HOH A O   1 
HETATM 3048 O O   . HOH C 3 .   ? 13.901  -12.337 -24.886 1.00 32.25 ?  519 HOH A O   1 
HETATM 3049 O O   . HOH C 3 .   ? 17.131  -29.516 15.730  1.00 37.53 ?  520 HOH A O   1 
HETATM 3050 O O   . HOH C 3 .   ? 0.344   -33.203 -8.564  1.00 40.50 ?  521 HOH A O   1 
HETATM 3051 O O   . HOH C 3 .   ? 28.959  -10.865 16.354  1.00 37.75 ?  522 HOH A O   1 
HETATM 3052 O O   . HOH C 3 .   ? 2.569   -6.288  12.355  1.00 37.25 ?  523 HOH A O   1 
HETATM 3053 O O   . HOH C 3 .   ? 30.975  -15.402 4.855   1.00 26.29 ?  524 HOH A O   1 
HETATM 3054 O O   . HOH C 3 .   ? 13.307  -9.235  11.798  1.00 25.60 ?  525 HOH A O   1 
HETATM 3055 O O   . HOH C 3 .   ? 32.059  -20.533 9.297   1.00 33.11 ?  526 HOH A O   1 
HETATM 3056 O O   . HOH C 3 .   ? 22.121  -22.078 -11.660 1.00 38.74 ?  527 HOH A O   1 
HETATM 3057 O O   . HOH C 3 .   ? 24.313  0.725   -18.906 1.00 40.99 ?  528 HOH A O   1 
HETATM 3058 O O   . HOH C 3 .   ? 20.197  -15.462 -23.668 1.00 31.72 ?  529 HOH A O   1 
HETATM 3059 O O   . HOH C 3 .   ? 6.895   -3.267  -15.806 1.00 39.96 ?  530 HOH A O   1 
HETATM 3060 O O   . HOH C 3 .   ? 6.482   -27.671 12.607  1.00 28.44 ?  531 HOH A O   1 
HETATM 3061 O O   . HOH C 3 .   ? 33.684  -0.146  -4.993  1.00 29.20 ?  532 HOH A O   1 
HETATM 3062 O O   . HOH C 3 .   ? 2.823   -18.928 -7.381  1.00 30.66 ?  533 HOH A O   1 
HETATM 3063 O O   . HOH C 3 .   ? -1.939  -31.594 10.388  1.00 24.68 ?  534 HOH A O   1 
HETATM 3064 O O   . HOH C 3 .   ? 34.108  0.818   -9.114  1.00 36.30 ?  535 HOH A O   1 
HETATM 3065 O O   . HOH C 3 .   ? -3.167  -14.279 -2.065  1.00 36.43 ?  536 HOH A O   1 
HETATM 3066 O O   . HOH C 3 .   ? 2.015   -15.491 0.102   1.00 30.10 ?  537 HOH A O   1 
HETATM 3067 O O   . HOH C 3 .   ? 21.482  -26.332 6.307   1.00 31.12 ?  538 HOH A O   1 
HETATM 3068 O O   . HOH C 3 .   ? 12.889  -18.887 -8.537  1.00 26.16 ?  539 HOH A O   1 
HETATM 3069 O O   . HOH C 3 .   ? -2.154  -35.064 9.075   1.00 33.32 ?  540 HOH A O   1 
HETATM 3070 O O   . HOH C 3 .   ? 28.265  -10.923 -5.175  1.00 22.37 ?  541 HOH A O   1 
HETATM 3071 O O   . HOH C 3 .   ? 47.618  -9.907  -7.234  1.00 48.61 ?  542 HOH A O   1 
HETATM 3072 O O   . HOH C 3 .   ? 10.470  -45.418 5.513   1.00 43.22 ?  543 HOH A O   1 
HETATM 3073 O O   . HOH C 3 .   ? 18.668  -17.938 -18.071 1.00 39.02 ?  544 HOH A O   1 
HETATM 3074 O O   . HOH C 3 .   ? 43.054  -15.429 8.089   1.00 38.23 ?  545 HOH A O   1 
HETATM 3075 O O   . HOH C 3 .   ? 17.621  -39.815 3.375   1.00 37.87 ?  546 HOH A O   1 
HETATM 3076 O O   . HOH C 3 .   ? 22.017  2.980   2.743   1.00 24.63 ?  547 HOH A O   1 
HETATM 3077 O O   . HOH C 3 .   ? 13.702  -18.604 17.881  1.00 36.50 ?  548 HOH A O   1 
HETATM 3078 O O   . HOH C 3 .   ? -2.089  -37.397 0.599   1.00 38.42 ?  549 HOH A O   1 
HETATM 3079 O O   . HOH C 3 .   ? 12.004  -5.799  -24.382 1.00 34.44 ?  550 HOH A O   1 
HETATM 3080 O O   . HOH C 3 .   ? 16.459  -12.370 16.404  1.00 29.37 ?  551 HOH A O   1 
HETATM 3081 O O   . HOH C 3 .   ? 4.602   -27.314 16.160  1.00 29.67 ?  552 HOH A O   1 
HETATM 3082 O O   . HOH C 3 .   ? 6.115   -13.082 15.875  1.00 33.40 ?  553 HOH A O   1 
HETATM 3083 O O   . HOH C 3 .   ? 0.281   -32.651 -5.923  1.00 38.45 ?  554 HOH A O   1 
HETATM 3084 O O   . HOH C 3 .   ? 4.261   -28.318 10.988  1.00 25.68 ?  555 HOH A O   1 
HETATM 3085 O O   . HOH C 3 .   ? 25.258  -19.426 2.408   1.00 31.12 ?  556 HOH A O   1 
HETATM 3086 O O   . HOH C 3 .   ? 6.110   -39.405 -4.900  1.00 40.20 ?  557 HOH A O   1 
HETATM 3087 O O   . HOH C 3 .   ? 1.323   -10.038 -13.523 1.00 32.01 ?  558 HOH A O   1 
HETATM 3088 O O   . HOH C 3 .   ? 19.272  0.079   -14.527 1.00 30.61 ?  559 HOH A O   1 
HETATM 3089 O O   . HOH C 3 .   ? 32.203  0.835   0.705   1.00 31.03 ?  560 HOH A O   1 
HETATM 3090 O O   . HOH C 3 .   ? 3.711   -6.623  7.321   1.00 28.61 ?  561 HOH A O   1 
HETATM 3091 O O   . HOH C 3 .   ? 22.013  -16.297 -12.186 1.00 26.11 ?  562 HOH A O   1 
HETATM 3092 O O   . HOH C 3 .   ? 25.321  -11.715 17.287  1.00 39.09 ?  563 HOH A O   1 
HETATM 3093 O O   . HOH C 3 .   ? 41.533  -21.305 -7.944  1.00 34.59 ?  564 HOH A O   1 
HETATM 3094 O O   . HOH C 3 .   ? 15.070  -5.951  11.531  1.00 43.18 ?  565 HOH A O   1 
HETATM 3095 O O   . HOH C 3 .   ? -4.353  -14.057 2.176   1.00 40.61 ?  566 HOH A O   1 
HETATM 3096 O O   . HOH C 3 .   ? 10.316  2.584   9.545   1.00 43.36 ?  567 HOH A O   1 
HETATM 3097 O O   . HOH C 3 .   ? 12.133  -26.077 16.705  1.00 32.06 ?  568 HOH A O   1 
HETATM 3098 O O   . HOH C 3 .   ? 5.931   -3.780  3.383   1.00 33.25 ?  569 HOH A O   1 
HETATM 3099 O O   . HOH C 3 .   ? 50.551  -6.525  -2.721  1.00 41.66 ?  570 HOH A O   1 
HETATM 3100 O O   . HOH C 3 .   ? 10.618  -20.246 -7.358  1.00 23.81 ?  571 HOH A O   1 
HETATM 3101 O O   . HOH C 3 .   ? 28.727  -4.782  14.234  1.00 33.64 ?  572 HOH A O   1 
HETATM 3102 O O   . HOH C 3 .   ? 3.393   -8.293  5.490   1.00 34.23 ?  573 HOH A O   1 
HETATM 3103 O O   . HOH C 3 .   ? 14.305  -21.824 -8.567  1.00 29.33 ?  574 HOH A O   1 
HETATM 3104 O O   . HOH C 3 .   ? 2.418   -23.012 10.795  1.00 27.28 ?  575 HOH A O   1 
HETATM 3105 O O   . HOH C 3 .   ? -7.000  -27.431 -3.759  1.00 35.86 ?  576 HOH A O   1 
HETATM 3106 O O   . HOH C 3 .   ? -13.316 -28.158 -1.001  1.00 35.93 ?  577 HOH A O   1 
HETATM 3107 O O   . HOH C 3 .   ? 9.445   0.861   -3.778  1.00 37.73 ?  578 HOH A O   1 
HETATM 3108 O O   . HOH C 3 .   ? 27.216  -9.731  -7.586  1.00 18.88 ?  579 HOH A O   1 
HETATM 3109 O O   . HOH C 3 .   ? 3.123   -16.677 -3.452  1.00 27.20 ?  580 HOH A O   1 
HETATM 3110 O O   . HOH C 3 .   ? 24.619  -26.338 11.279  1.00 41.48 ?  581 HOH A O   1 
HETATM 3111 O O   . HOH C 3 .   ? 7.715   -1.381  3.351   1.00 38.60 ?  582 HOH A O   1 
HETATM 3112 O O   . HOH C 3 .   ? 4.081   -36.234 15.791  1.00 36.75 ?  583 HOH A O   1 
HETATM 3113 O O   . HOH C 3 .   ? -11.161 -27.350 -0.279  1.00 34.77 ?  584 HOH A O   1 
HETATM 3114 O O   . HOH C 3 .   ? 19.681  -40.744 5.030   1.00 40.79 ?  585 HOH A O   1 
HETATM 3115 O O   . HOH C 3 .   ? 29.079  -5.486  -20.948 1.00 38.23 ?  586 HOH A O   1 
HETATM 3116 O O   . HOH C 3 .   ? 6.982   -17.934 -19.078 1.00 32.77 ?  587 HOH A O   1 
HETATM 3117 O O   . HOH C 3 .   ? 46.359  -5.990  -11.068 1.00 42.91 ?  588 HOH A O   1 
HETATM 3118 O O   . HOH C 3 .   ? 8.934   -13.368 18.527  1.00 28.29 ?  589 HOH A O   1 
HETATM 3119 O O   . HOH C 3 .   ? 0.337   -10.103 3.954   1.00 30.19 ?  590 HOH A O   1 
HETATM 3120 O O   . HOH C 3 .   ? 27.079  -20.602 4.212   1.00 32.92 ?  591 HOH A O   1 
HETATM 3121 O O   . HOH C 3 .   ? 26.710  -15.759 -13.016 1.00 40.75 ?  592 HOH A O   1 
HETATM 3122 O O   . HOH C 3 .   ? 16.042  2.479   4.135   1.00 30.23 ?  593 HOH A O   1 
HETATM 3123 O O   . HOH C 3 .   ? 17.124  -9.971  17.105  1.00 31.35 ?  594 HOH A O   1 
HETATM 3124 O O   . HOH C 3 .   ? 16.444  -8.311  14.640  1.00 35.63 ?  595 HOH A O   1 
HETATM 3125 O O   . HOH C 3 .   ? 27.228  -24.946 10.916  1.00 33.61 ?  596 HOH A O   1 
HETATM 3126 O O   . HOH C 3 .   ? 47.082  -18.264 -4.743  1.00 40.59 ?  597 HOH A O   1 
HETATM 3127 O O   . HOH C 3 .   ? 11.723  -24.727 18.271  1.00 32.70 ?  598 HOH A O   1 
HETATM 3128 O O   . HOH C 3 .   ? 43.327  -20.283 -3.445  1.00 34.46 ?  599 HOH A O   1 
HETATM 3129 O O   . HOH C 3 .   ? 14.519  -38.640 14.431  1.00 39.42 ?  600 HOH A O   1 
HETATM 3130 O O   . HOH C 3 .   ? 17.617  -15.190 -24.658 1.00 35.39 ?  601 HOH A O   1 
HETATM 3131 O O   . HOH C 3 .   ? 8.197   -11.808 -25.004 1.00 29.26 ?  602 HOH A O   1 
HETATM 3132 O O   . HOH C 3 .   ? 34.657  -2.537  11.421  1.00 33.39 ?  603 HOH A O   1 
HETATM 3133 O O   . HOH C 3 .   ? 3.896   -35.667 -10.055 1.00 38.91 ?  604 HOH A O   1 
HETATM 3134 O O   . HOH C 3 .   ? 2.601   -9.936  -21.866 1.00 53.80 ?  605 HOH A O   1 
HETATM 3135 O O   . HOH C 3 .   ? 5.996   -5.957  -17.651 1.00 36.75 ?  606 HOH A O   1 
HETATM 3136 O O   . HOH C 3 .   ? 54.964  -20.065 -2.034  1.00 43.18 ?  607 HOH A O   1 
HETATM 3137 O O   . HOH C 3 .   ? 1.742   -36.552 16.231  1.00 43.80 ?  608 HOH A O   1 
HETATM 3138 O O   . HOH C 3 .   ? -2.910  -38.241 12.743  1.00 38.98 ?  609 HOH A O   1 
HETATM 3139 O O   . HOH C 3 .   ? 19.050  6.729   -10.925 1.00 38.47 ?  610 HOH A O   1 
HETATM 3140 O O   . HOH C 3 .   ? 50.080  -10.348 -3.887  1.00 43.92 ?  611 HOH A O   1 
HETATM 3141 O O   . HOH C 3 .   ? 6.233   -44.907 -0.231  1.00 48.95 ?  612 HOH A O   1 
HETATM 3142 O O   . HOH C 3 .   ? 9.346   -45.252 8.303   1.00 44.12 ?  613 HOH A O   1 
HETATM 3143 O O   . HOH C 3 .   ? 26.169  -34.431 0.032   1.00 39.15 ?  614 HOH A O   1 
HETATM 3144 O O   . HOH C 3 .   ? 44.019  -18.769 3.479   1.00 37.42 ?  615 HOH A O   1 
HETATM 3145 O O   . HOH C 3 .   ? 17.131  -42.736 3.118   1.00 45.39 ?  616 HOH A O   1 
HETATM 3146 O O   . HOH C 3 .   ? 2.098   -45.759 4.222   1.00 48.74 ?  617 HOH A O   1 
HETATM 3147 O O   . HOH C 3 .   ? 44.080  -20.192 1.084   1.00 37.70 ?  618 HOH A O   1 
HETATM 3148 O O   . HOH C 3 .   ? 27.350  -9.092  15.907  1.00 35.74 ?  619 HOH A O   1 
HETATM 3149 O O   . HOH C 3 .   ? 25.367  -5.215  -24.755 1.00 44.93 ?  620 HOH A O   1 
HETATM 3150 O O   . HOH C 3 .   ? -0.016  -10.241 9.284   1.00 48.03 ?  621 HOH A O   1 
HETATM 3151 O O   . HOH C 3 .   ? 10.166  -20.904 -20.059 1.00 38.68 ?  622 HOH A O   1 
HETATM 3152 O O   . HOH C 3 .   ? 5.906   -5.743  14.585  1.00 34.97 ?  623 HOH A O   1 
HETATM 3153 O O   . HOH C 3 .   ? 48.435  -11.517 -5.534  1.00 43.62 ?  624 HOH A O   1 
HETATM 3154 O O   . HOH C 3 .   ? 45.017  -10.374 4.678   1.00 62.51 ?  625 HOH A O   1 
HETATM 3155 O O   . HOH C 3 .   ? 27.868  -33.927 0.768   1.00 37.75 ?  626 HOH A O   1 
HETATM 3156 O O   . HOH C 3 .   ? 24.635  -17.793 20.212  1.00 43.20 ?  627 HOH A O   1 
HETATM 3157 O O   . HOH C 3 .   ? 26.981  -21.968 2.692   1.00 52.69 ?  628 HOH A O   1 
HETATM 3158 O O   . HOH C 3 .   ? 0.843   -9.203  -10.911 1.00 34.60 ?  629 HOH A O   1 
HETATM 3159 O O   . HOH C 3 .   ? -2.532  -17.307 20.011  1.00 43.90 ?  630 HOH A O   1 
HETATM 3160 O O   . HOH C 3 .   ? -7.575  -36.281 2.787   1.00 34.22 ?  631 HOH A O   1 
HETATM 3161 O O   . HOH C 3 .   ? 16.993  1.103   -14.194 1.00 29.67 ?  632 HOH A O   1 
HETATM 3162 O O   . HOH C 3 .   ? 12.636  -20.967 -19.032 1.00 40.45 ?  633 HOH A O   1 
HETATM 3163 O O   . HOH C 3 .   ? -0.257  -34.910 18.017  1.00 48.33 ?  634 HOH A O   1 
HETATM 3164 O O   . HOH C 3 .   ? 33.183  2.179   2.939   1.00 36.76 ?  635 HOH A O   1 
HETATM 3165 O O   . HOH C 3 .   ? 20.505  -28.683 6.650   1.00 33.19 ?  636 HOH A O   1 
HETATM 3166 O O   . HOH C 3 .   ? 12.198  0.720   -8.160  1.00 32.35 ?  637 HOH A O   1 
HETATM 3167 O O   . HOH C 3 .   ? 11.170  -1.809  -17.719 1.00 38.81 ?  638 HOH A O   1 
HETATM 3168 O O   . HOH C 3 .   ? 13.008  -35.476 16.812  1.00 35.39 ?  639 HOH A O   1 
HETATM 3169 O O   . HOH C 3 .   ? 10.464  -4.837  -18.296 1.00 35.10 ?  640 HOH A O   1 
HETATM 3170 O O   . HOH C 3 .   ? -2.808  -34.724 17.189  1.00 39.04 ?  641 HOH A O   1 
HETATM 3171 O O   . HOH C 3 .   ? 9.993   1.715   -9.217  1.00 44.45 ?  642 HOH A O   1 
HETATM 3172 O O   . HOH C 3 .   ? 6.575   -29.239 14.801  1.00 36.00 ?  643 HOH A O   1 
HETATM 3173 O O   . HOH C 3 .   ? 6.034   -33.639 15.828  1.00 36.26 ?  644 HOH A O   1 
HETATM 3174 O O   . HOH C 3 .   ? 7.635   -4.543  -17.186 1.00 45.35 ?  645 HOH A O   1 
HETATM 3175 O O   . HOH C 3 .   ? 36.503  0.362   -8.435  1.00 38.74 ?  646 HOH A O   1 
HETATM 3176 O O   . HOH C 3 .   ? 35.664  1.821   3.796   1.00 35.59 ?  647 HOH A O   1 
HETATM 3177 O O   . HOH C 3 .   ? 8.268   -1.144  -16.601 1.00 37.64 ?  648 HOH A O   1 
HETATM 3178 O O   . HOH C 3 .   ? 47.902  -5.688  1.560   1.00 44.35 ?  649 HOH A O   1 
HETATM 3179 O O   . HOH C 3 .   ? -0.380  -39.821 12.955  1.00 39.54 ?  650 HOH A O   1 
HETATM 3180 O O   . HOH C 3 .   ? 5.251   -38.903 -8.541  1.00 55.50 ?  651 HOH A O   1 
HETATM 3181 O O   . HOH C 3 .   ? 17.511  -1.099  -21.056 1.00 45.79 ?  652 HOH A O   1 
HETATM 3182 O O   . HOH C 3 .   ? 21.691  -31.438 -16.561 1.00 48.35 ?  653 HOH A O   1 
HETATM 3183 O O   . HOH C 3 .   ? 2.046   -6.383  8.102   1.00 40.20 ?  654 HOH A O   1 
HETATM 3184 O O   . HOH C 3 .   ? 20.346  -35.832 -13.763 1.00 56.98 ?  655 HOH A O   1 
HETATM 3185 O O   . HOH C 3 .   ? 2.685   -12.356 20.273  1.00 38.84 ?  656 HOH A O   1 
HETATM 3186 O O   . HOH C 3 .   ? 31.280  -3.874  14.386  1.00 35.34 ?  657 HOH A O   1 
HETATM 3187 O O   . HOH C 3 .   ? 27.768  -6.489  16.347  1.00 44.65 ?  658 HOH A O   1 
HETATM 3188 O O   . HOH C 3 .   ? 25.532  -2.850  -25.831 1.00 52.33 ?  659 HOH A O   1 
HETATM 3189 O O   . HOH C 3 .   ? 10.305  -2.235  11.629  1.00 38.96 ?  660 HOH A O   1 
HETATM 3190 O O   . HOH C 3 .   ? 35.679  -1.874  13.665  1.00 42.27 ?  661 HOH A O   1 
HETATM 3191 O O   . HOH C 3 .   ? 13.950  1.497   -15.162 1.00 36.83 ?  662 HOH A O   1 
HETATM 3192 O O   . HOH C 3 .   ? 22.533  -34.491 -12.847 1.00 45.35 ?  663 HOH A O   1 
HETATM 3193 O O   . HOH C 3 .   ? 15.096  -22.912 -21.869 1.00 37.09 ?  664 HOH A O   1 
HETATM 3194 O O   . HOH C 3 .   ? 20.622  -28.958 -17.796 1.00 51.21 ?  665 HOH A O   1 
HETATM 3195 O O   . HOH C 3 .   ? 3.483   -30.258 17.493  1.00 39.91 ?  666 HOH A O   1 
HETATM 3196 O O   . HOH C 3 .   ? 33.794  -14.889 -12.939 1.00 45.17 ?  667 HOH A O   1 
HETATM 3197 O O   . HOH C 3 .   ? 19.035  0.824   -20.816 1.00 43.30 ?  668 HOH A O   1 
HETATM 3198 O O   . HOH C 3 .   ? 24.061  -32.735 -16.563 1.00 52.13 ?  669 HOH A O   1 
HETATM 3199 O O   . HOH C 3 .   ? 22.052  -26.980 -19.095 1.00 41.55 ?  670 HOH A O   1 
# 
