data_9JOS
# 
_entry.id   9JOS 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.398 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9JOS         pdb_00009jos 10.2210/pdb9jos/pdb 
WWPDB D_1300051873 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-11-27 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9JOS 
_pdbx_database_status.recvd_initial_deposition_date   2024-09-25 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              changyg@ouc.edu.cn 
_pdbx_contact_author.name_first         Yaoguang 
_pdbx_contact_author.name_last          Chang 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-8234-7272 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Chen, G.N.'  1 ? 
'Chang, Y.G.' 2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Structure of endo-1.3-fucanase from GH168 family at 1.70 Angstroms resulution.' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Chen, G.N.'  1 ? 
primary 'Chang, Y.G.' 2 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'Glycoside-hydrolase family GH114 TIM-barrel domain-containing protein' 46766.727 1   ? ? ? ? 
2 water   nat water                                                                   18.015    440 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MGSSHHHHHHSSGLVPRGSHMASMTGGQQMGRGSEFLGQHYLNSDGSRFVPKDFYPKFSWDTTPMYYMFGDTTRLLEPEE
VEFIAERTDFLCIEKSHGRTPLGAAELGAKHEAAAFKKIKPDMKVLFYFNSAYAWPFTSYNQAFTRNKIDEHPKLKSFLI
VDPKTAELAHRRNVFFFDVLNPELREWWSTTVAKGVAESGCDGAFIDQMHGFAWLRADKSEDVQKAMGEMMALLKRKMGP
DKILLGNNANQDIAKDAFPVMDASMFEHYNEKLLSKESLLQDWDDMLRIAQAGKMSIFRIGVESDPRASQDQGRRGSRRD
QPVLAKERAEYYLACYLIGAQPYSYFQYGWGWTLSSGSLHEFPELRKALGPPKGAYDRTTPDGWEFTREFEHASVWVNTE
TGNAKITWR
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MGSSHHHHHHSSGLVPRGSHMASMTGGQQMGRGSEFLGQHYLNSDGSRFVPKDFYPKFSWDTTPMYYMFGDTTRLLEPEE
VEFIAERTDFLCIEKSHGRTPLGAAELGAKHEAAAFKKIKPDMKVLFYFNSAYAWPFTSYNQAFTRNKIDEHPKLKSFLI
VDPKTAELAHRRNVFFFDVLNPELREWWSTTVAKGVAESGCDGAFIDQMHGFAWLRADKSEDVQKAMGEMMALLKRKMGP
DKILLGNNANQDIAKDAFPVMDASMFEHYNEKLLSKESLLQDWDDMLRIAQAGKMSIFRIGVESDPRASQDQGRRGSRRD
QPVLAKERAEYYLACYLIGAQPYSYFQYGWGWTLSSGSLHEFPELRKALGPPKGAYDRTTPDGWEFTREFEHASVWVNTE
TGNAKITWR
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLY n 
1 3   SER n 
1 4   SER n 
1 5   HIS n 
1 6   HIS n 
1 7   HIS n 
1 8   HIS n 
1 9   HIS n 
1 10  HIS n 
1 11  SER n 
1 12  SER n 
1 13  GLY n 
1 14  LEU n 
1 15  VAL n 
1 16  PRO n 
1 17  ARG n 
1 18  GLY n 
1 19  SER n 
1 20  HIS n 
1 21  MET n 
1 22  ALA n 
1 23  SER n 
1 24  MET n 
1 25  THR n 
1 26  GLY n 
1 27  GLY n 
1 28  GLN n 
1 29  GLN n 
1 30  MET n 
1 31  GLY n 
1 32  ARG n 
1 33  GLY n 
1 34  SER n 
1 35  GLU n 
1 36  PHE n 
1 37  LEU n 
1 38  GLY n 
1 39  GLN n 
1 40  HIS n 
1 41  TYR n 
1 42  LEU n 
1 43  ASN n 
1 44  SER n 
1 45  ASP n 
1 46  GLY n 
1 47  SER n 
1 48  ARG n 
1 49  PHE n 
1 50  VAL n 
1 51  PRO n 
1 52  LYS n 
1 53  ASP n 
1 54  PHE n 
1 55  TYR n 
1 56  PRO n 
1 57  LYS n 
1 58  PHE n 
1 59  SER n 
1 60  TRP n 
1 61  ASP n 
1 62  THR n 
1 63  THR n 
1 64  PRO n 
1 65  MET n 
1 66  TYR n 
1 67  TYR n 
1 68  MET n 
1 69  PHE n 
1 70  GLY n 
1 71  ASP n 
1 72  THR n 
1 73  THR n 
1 74  ARG n 
1 75  LEU n 
1 76  LEU n 
1 77  GLU n 
1 78  PRO n 
1 79  GLU n 
1 80  GLU n 
1 81  VAL n 
1 82  GLU n 
1 83  PHE n 
1 84  ILE n 
1 85  ALA n 
1 86  GLU n 
1 87  ARG n 
1 88  THR n 
1 89  ASP n 
1 90  PHE n 
1 91  LEU n 
1 92  CYS n 
1 93  ILE n 
1 94  GLU n 
1 95  LYS n 
1 96  SER n 
1 97  HIS n 
1 98  GLY n 
1 99  ARG n 
1 100 THR n 
1 101 PRO n 
1 102 LEU n 
1 103 GLY n 
1 104 ALA n 
1 105 ALA n 
1 106 GLU n 
1 107 LEU n 
1 108 GLY n 
1 109 ALA n 
1 110 LYS n 
1 111 HIS n 
1 112 GLU n 
1 113 ALA n 
1 114 ALA n 
1 115 ALA n 
1 116 PHE n 
1 117 LYS n 
1 118 LYS n 
1 119 ILE n 
1 120 LYS n 
1 121 PRO n 
1 122 ASP n 
1 123 MET n 
1 124 LYS n 
1 125 VAL n 
1 126 LEU n 
1 127 PHE n 
1 128 TYR n 
1 129 PHE n 
1 130 ASN n 
1 131 SER n 
1 132 ALA n 
1 133 TYR n 
1 134 ALA n 
1 135 TRP n 
1 136 PRO n 
1 137 PHE n 
1 138 THR n 
1 139 SER n 
1 140 TYR n 
1 141 ASN n 
1 142 GLN n 
1 143 ALA n 
1 144 PHE n 
1 145 THR n 
1 146 ARG n 
1 147 ASN n 
1 148 LYS n 
1 149 ILE n 
1 150 ASP n 
1 151 GLU n 
1 152 HIS n 
1 153 PRO n 
1 154 LYS n 
1 155 LEU n 
1 156 LYS n 
1 157 SER n 
1 158 PHE n 
1 159 LEU n 
1 160 ILE n 
1 161 VAL n 
1 162 ASP n 
1 163 PRO n 
1 164 LYS n 
1 165 THR n 
1 166 ALA n 
1 167 GLU n 
1 168 LEU n 
1 169 ALA n 
1 170 HIS n 
1 171 ARG n 
1 172 ARG n 
1 173 ASN n 
1 174 VAL n 
1 175 PHE n 
1 176 PHE n 
1 177 PHE n 
1 178 ASP n 
1 179 VAL n 
1 180 LEU n 
1 181 ASN n 
1 182 PRO n 
1 183 GLU n 
1 184 LEU n 
1 185 ARG n 
1 186 GLU n 
1 187 TRP n 
1 188 TRP n 
1 189 SER n 
1 190 THR n 
1 191 THR n 
1 192 VAL n 
1 193 ALA n 
1 194 LYS n 
1 195 GLY n 
1 196 VAL n 
1 197 ALA n 
1 198 GLU n 
1 199 SER n 
1 200 GLY n 
1 201 CYS n 
1 202 ASP n 
1 203 GLY n 
1 204 ALA n 
1 205 PHE n 
1 206 ILE n 
1 207 ASP n 
1 208 GLN n 
1 209 MET n 
1 210 HIS n 
1 211 GLY n 
1 212 PHE n 
1 213 ALA n 
1 214 TRP n 
1 215 LEU n 
1 216 ARG n 
1 217 ALA n 
1 218 ASP n 
1 219 LYS n 
1 220 SER n 
1 221 GLU n 
1 222 ASP n 
1 223 VAL n 
1 224 GLN n 
1 225 LYS n 
1 226 ALA n 
1 227 MET n 
1 228 GLY n 
1 229 GLU n 
1 230 MET n 
1 231 MET n 
1 232 ALA n 
1 233 LEU n 
1 234 LEU n 
1 235 LYS n 
1 236 ARG n 
1 237 LYS n 
1 238 MET n 
1 239 GLY n 
1 240 PRO n 
1 241 ASP n 
1 242 LYS n 
1 243 ILE n 
1 244 LEU n 
1 245 LEU n 
1 246 GLY n 
1 247 ASN n 
1 248 ASN n 
1 249 ALA n 
1 250 ASN n 
1 251 GLN n 
1 252 ASP n 
1 253 ILE n 
1 254 ALA n 
1 255 LYS n 
1 256 ASP n 
1 257 ALA n 
1 258 PHE n 
1 259 PRO n 
1 260 VAL n 
1 261 MET n 
1 262 ASP n 
1 263 ALA n 
1 264 SER n 
1 265 MET n 
1 266 PHE n 
1 267 GLU n 
1 268 HIS n 
1 269 TYR n 
1 270 ASN n 
1 271 GLU n 
1 272 LYS n 
1 273 LEU n 
1 274 LEU n 
1 275 SER n 
1 276 LYS n 
1 277 GLU n 
1 278 SER n 
1 279 LEU n 
1 280 LEU n 
1 281 GLN n 
1 282 ASP n 
1 283 TRP n 
1 284 ASP n 
1 285 ASP n 
1 286 MET n 
1 287 LEU n 
1 288 ARG n 
1 289 ILE n 
1 290 ALA n 
1 291 GLN n 
1 292 ALA n 
1 293 GLY n 
1 294 LYS n 
1 295 MET n 
1 296 SER n 
1 297 ILE n 
1 298 PHE n 
1 299 ARG n 
1 300 ILE n 
1 301 GLY n 
1 302 VAL n 
1 303 GLU n 
1 304 SER n 
1 305 ASP n 
1 306 PRO n 
1 307 ARG n 
1 308 ALA n 
1 309 SER n 
1 310 GLN n 
1 311 ASP n 
1 312 GLN n 
1 313 GLY n 
1 314 ARG n 
1 315 ARG n 
1 316 GLY n 
1 317 SER n 
1 318 ARG n 
1 319 ARG n 
1 320 ASP n 
1 321 GLN n 
1 322 PRO n 
1 323 VAL n 
1 324 LEU n 
1 325 ALA n 
1 326 LYS n 
1 327 GLU n 
1 328 ARG n 
1 329 ALA n 
1 330 GLU n 
1 331 TYR n 
1 332 TYR n 
1 333 LEU n 
1 334 ALA n 
1 335 CYS n 
1 336 TYR n 
1 337 LEU n 
1 338 ILE n 
1 339 GLY n 
1 340 ALA n 
1 341 GLN n 
1 342 PRO n 
1 343 TYR n 
1 344 SER n 
1 345 TYR n 
1 346 PHE n 
1 347 GLN n 
1 348 TYR n 
1 349 GLY n 
1 350 TRP n 
1 351 GLY n 
1 352 TRP n 
1 353 THR n 
1 354 LEU n 
1 355 SER n 
1 356 SER n 
1 357 GLY n 
1 358 SER n 
1 359 LEU n 
1 360 HIS n 
1 361 GLU n 
1 362 PHE n 
1 363 PRO n 
1 364 GLU n 
1 365 LEU n 
1 366 ARG n 
1 367 LYS n 
1 368 ALA n 
1 369 LEU n 
1 370 GLY n 
1 371 PRO n 
1 372 PRO n 
1 373 LYS n 
1 374 GLY n 
1 375 ALA n 
1 376 TYR n 
1 377 ASP n 
1 378 ARG n 
1 379 THR n 
1 380 THR n 
1 381 PRO n 
1 382 ASP n 
1 383 GLY n 
1 384 TRP n 
1 385 GLU n 
1 386 PHE n 
1 387 THR n 
1 388 ARG n 
1 389 GLU n 
1 390 PHE n 
1 391 GLU n 
1 392 HIS n 
1 393 ALA n 
1 394 SER n 
1 395 VAL n 
1 396 TRP n 
1 397 VAL n 
1 398 ASN n 
1 399 THR n 
1 400 GLU n 
1 401 THR n 
1 402 GLY n 
1 403 ASN n 
1 404 ALA n 
1 405 LYS n 
1 406 ILE n 
1 407 THR n 
1 408 TRP n 
1 409 ARG n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   409 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 Poly41_55130 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Novipirellula artificiosorum' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2528016 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -35 ?   ?   ?   A . n 
A 1 2   GLY 2   -34 ?   ?   ?   A . n 
A 1 3   SER 3   -33 ?   ?   ?   A . n 
A 1 4   SER 4   -32 ?   ?   ?   A . n 
A 1 5   HIS 5   -31 ?   ?   ?   A . n 
A 1 6   HIS 6   -30 ?   ?   ?   A . n 
A 1 7   HIS 7   -29 ?   ?   ?   A . n 
A 1 8   HIS 8   -28 ?   ?   ?   A . n 
A 1 9   HIS 9   -27 ?   ?   ?   A . n 
A 1 10  HIS 10  -26 ?   ?   ?   A . n 
A 1 11  SER 11  -25 ?   ?   ?   A . n 
A 1 12  SER 12  -24 ?   ?   ?   A . n 
A 1 13  GLY 13  -23 ?   ?   ?   A . n 
A 1 14  LEU 14  -22 ?   ?   ?   A . n 
A 1 15  VAL 15  -21 ?   ?   ?   A . n 
A 1 16  PRO 16  -20 ?   ?   ?   A . n 
A 1 17  ARG 17  -19 ?   ?   ?   A . n 
A 1 18  GLY 18  -18 ?   ?   ?   A . n 
A 1 19  SER 19  -17 ?   ?   ?   A . n 
A 1 20  HIS 20  -16 ?   ?   ?   A . n 
A 1 21  MET 21  -15 ?   ?   ?   A . n 
A 1 22  ALA 22  -14 ?   ?   ?   A . n 
A 1 23  SER 23  -13 ?   ?   ?   A . n 
A 1 24  MET 24  -12 ?   ?   ?   A . n 
A 1 25  THR 25  -11 ?   ?   ?   A . n 
A 1 26  GLY 26  -10 ?   ?   ?   A . n 
A 1 27  GLY 27  -9  ?   ?   ?   A . n 
A 1 28  GLN 28  -8  ?   ?   ?   A . n 
A 1 29  GLN 29  -7  ?   ?   ?   A . n 
A 1 30  MET 30  -6  ?   ?   ?   A . n 
A 1 31  GLY 31  -5  ?   ?   ?   A . n 
A 1 32  ARG 32  -4  ?   ?   ?   A . n 
A 1 33  GLY 33  -3  ?   ?   ?   A . n 
A 1 34  SER 34  -2  ?   ?   ?   A . n 
A 1 35  GLU 35  -1  ?   ?   ?   A . n 
A 1 36  PHE 36  0   ?   ?   ?   A . n 
A 1 37  LEU 37  1   ?   ?   ?   A . n 
A 1 38  GLY 38  2   2   GLY GLY A . n 
A 1 39  GLN 39  3   3   GLN GLN A . n 
A 1 40  HIS 40  4   4   HIS HIS A . n 
A 1 41  TYR 41  5   5   TYR TYR A . n 
A 1 42  LEU 42  6   6   LEU LEU A . n 
A 1 43  ASN 43  7   7   ASN ASN A . n 
A 1 44  SER 44  8   8   SER SER A . n 
A 1 45  ASP 45  9   9   ASP ASP A . n 
A 1 46  GLY 46  10  10  GLY GLY A . n 
A 1 47  SER 47  11  11  SER SER A . n 
A 1 48  ARG 48  12  12  ARG ARG A . n 
A 1 49  PHE 49  13  13  PHE PHE A . n 
A 1 50  VAL 50  14  14  VAL VAL A . n 
A 1 51  PRO 51  15  15  PRO PRO A . n 
A 1 52  LYS 52  16  16  LYS LYS A . n 
A 1 53  ASP 53  17  17  ASP ASP A . n 
A 1 54  PHE 54  18  18  PHE PHE A . n 
A 1 55  TYR 55  19  19  TYR TYR A . n 
A 1 56  PRO 56  20  20  PRO PRO A . n 
A 1 57  LYS 57  21  21  LYS LYS A . n 
A 1 58  PHE 58  22  22  PHE PHE A . n 
A 1 59  SER 59  23  23  SER SER A . n 
A 1 60  TRP 60  24  24  TRP TRP A . n 
A 1 61  ASP 61  25  25  ASP ASP A . n 
A 1 62  THR 62  26  26  THR THR A . n 
A 1 63  THR 63  27  27  THR THR A . n 
A 1 64  PRO 64  28  28  PRO PRO A . n 
A 1 65  MET 65  29  29  MET MET A . n 
A 1 66  TYR 66  30  30  TYR TYR A . n 
A 1 67  TYR 67  31  31  TYR TYR A . n 
A 1 68  MET 68  32  32  MET MET A . n 
A 1 69  PHE 69  33  33  PHE PHE A . n 
A 1 70  GLY 70  34  34  GLY GLY A . n 
A 1 71  ASP 71  35  35  ASP ASP A . n 
A 1 72  THR 72  36  36  THR THR A . n 
A 1 73  THR 73  37  37  THR THR A . n 
A 1 74  ARG 74  38  38  ARG ARG A . n 
A 1 75  LEU 75  39  39  LEU LEU A . n 
A 1 76  LEU 76  40  40  LEU LEU A . n 
A 1 77  GLU 77  41  41  GLU GLU A . n 
A 1 78  PRO 78  42  42  PRO PRO A . n 
A 1 79  GLU 79  43  43  GLU GLU A . n 
A 1 80  GLU 80  44  44  GLU GLU A . n 
A 1 81  VAL 81  45  45  VAL VAL A . n 
A 1 82  GLU 82  46  46  GLU GLU A . n 
A 1 83  PHE 83  47  47  PHE PHE A . n 
A 1 84  ILE 84  48  48  ILE ILE A . n 
A 1 85  ALA 85  49  49  ALA ALA A . n 
A 1 86  GLU 86  50  50  GLU GLU A . n 
A 1 87  ARG 87  51  51  ARG ARG A . n 
A 1 88  THR 88  52  52  THR THR A . n 
A 1 89  ASP 89  53  53  ASP ASP A . n 
A 1 90  PHE 90  54  54  PHE PHE A . n 
A 1 91  LEU 91  55  55  LEU LEU A . n 
A 1 92  CYS 92  56  56  CYS CYS A . n 
A 1 93  ILE 93  57  57  ILE ILE A . n 
A 1 94  GLU 94  58  58  GLU GLU A . n 
A 1 95  LYS 95  59  59  LYS LYS A . n 
A 1 96  SER 96  60  60  SER SER A . n 
A 1 97  HIS 97  61  61  HIS HIS A . n 
A 1 98  GLY 98  62  62  GLY GLY A . n 
A 1 99  ARG 99  63  63  ARG ARG A . n 
A 1 100 THR 100 64  64  THR THR A . n 
A 1 101 PRO 101 65  65  PRO PRO A . n 
A 1 102 LEU 102 66  66  LEU LEU A . n 
A 1 103 GLY 103 67  67  GLY GLY A . n 
A 1 104 ALA 104 68  68  ALA ALA A . n 
A 1 105 ALA 105 69  69  ALA ALA A . n 
A 1 106 GLU 106 70  70  GLU GLU A . n 
A 1 107 LEU 107 71  71  LEU LEU A . n 
A 1 108 GLY 108 72  72  GLY GLY A . n 
A 1 109 ALA 109 73  73  ALA ALA A . n 
A 1 110 LYS 110 74  74  LYS LYS A . n 
A 1 111 HIS 111 75  75  HIS HIS A . n 
A 1 112 GLU 112 76  76  GLU GLU A . n 
A 1 113 ALA 113 77  77  ALA ALA A . n 
A 1 114 ALA 114 78  78  ALA ALA A . n 
A 1 115 ALA 115 79  79  ALA ALA A . n 
A 1 116 PHE 116 80  80  PHE PHE A . n 
A 1 117 LYS 117 81  81  LYS LYS A . n 
A 1 118 LYS 118 82  82  LYS LYS A . n 
A 1 119 ILE 119 83  83  ILE ILE A . n 
A 1 120 LYS 120 84  84  LYS LYS A . n 
A 1 121 PRO 121 85  85  PRO PRO A . n 
A 1 122 ASP 122 86  86  ASP ASP A . n 
A 1 123 MET 123 87  87  MET MET A . n 
A 1 124 LYS 124 88  88  LYS LYS A . n 
A 1 125 VAL 125 89  89  VAL VAL A . n 
A 1 126 LEU 126 90  90  LEU LEU A . n 
A 1 127 PHE 127 91  91  PHE PHE A . n 
A 1 128 TYR 128 92  92  TYR TYR A . n 
A 1 129 PHE 129 93  93  PHE PHE A . n 
A 1 130 ASN 130 94  94  ASN ASN A . n 
A 1 131 SER 131 95  95  SER SER A . n 
A 1 132 ALA 132 96  96  ALA ALA A . n 
A 1 133 TYR 133 97  97  TYR TYR A . n 
A 1 134 ALA 134 98  98  ALA ALA A . n 
A 1 135 TRP 135 99  99  TRP TRP A . n 
A 1 136 PRO 136 100 100 PRO PRO A . n 
A 1 137 PHE 137 101 101 PHE PHE A . n 
A 1 138 THR 138 102 102 THR THR A . n 
A 1 139 SER 139 103 103 SER SER A . n 
A 1 140 TYR 140 104 104 TYR TYR A . n 
A 1 141 ASN 141 105 105 ASN ASN A . n 
A 1 142 GLN 142 106 106 GLN GLN A . n 
A 1 143 ALA 143 107 107 ALA ALA A . n 
A 1 144 PHE 144 108 108 PHE PHE A . n 
A 1 145 THR 145 109 109 THR THR A . n 
A 1 146 ARG 146 110 110 ARG ARG A . n 
A 1 147 ASN 147 111 111 ASN ASN A . n 
A 1 148 LYS 148 112 112 LYS LYS A . n 
A 1 149 ILE 149 113 113 ILE ILE A . n 
A 1 150 ASP 150 114 114 ASP ASP A . n 
A 1 151 GLU 151 115 115 GLU GLU A . n 
A 1 152 HIS 152 116 116 HIS HIS A . n 
A 1 153 PRO 153 117 117 PRO PRO A . n 
A 1 154 LYS 154 118 118 LYS LYS A . n 
A 1 155 LEU 155 119 119 LEU LEU A . n 
A 1 156 LYS 156 120 120 LYS LYS A . n 
A 1 157 SER 157 121 121 SER SER A . n 
A 1 158 PHE 158 122 122 PHE PHE A . n 
A 1 159 LEU 159 123 123 LEU LEU A . n 
A 1 160 ILE 160 124 124 ILE ILE A . n 
A 1 161 VAL 161 125 125 VAL VAL A . n 
A 1 162 ASP 162 126 126 ASP ASP A . n 
A 1 163 PRO 163 127 127 PRO PRO A . n 
A 1 164 LYS 164 128 128 LYS LYS A . n 
A 1 165 THR 165 129 129 THR THR A . n 
A 1 166 ALA 166 130 130 ALA ALA A . n 
A 1 167 GLU 167 131 131 GLU GLU A . n 
A 1 168 LEU 168 132 132 LEU LEU A . n 
A 1 169 ALA 169 133 133 ALA ALA A . n 
A 1 170 HIS 170 134 134 HIS HIS A . n 
A 1 171 ARG 171 135 135 ARG ARG A . n 
A 1 172 ARG 172 136 136 ARG ARG A . n 
A 1 173 ASN 173 137 137 ASN ASN A . n 
A 1 174 VAL 174 138 138 VAL VAL A . n 
A 1 175 PHE 175 139 139 PHE PHE A . n 
A 1 176 PHE 176 140 140 PHE PHE A . n 
A 1 177 PHE 177 141 141 PHE PHE A . n 
A 1 178 ASP 178 142 142 ASP ASP A . n 
A 1 179 VAL 179 143 143 VAL VAL A . n 
A 1 180 LEU 180 144 144 LEU LEU A . n 
A 1 181 ASN 181 145 145 ASN ASN A . n 
A 1 182 PRO 182 146 146 PRO PRO A . n 
A 1 183 GLU 183 147 147 GLU GLU A . n 
A 1 184 LEU 184 148 148 LEU LEU A . n 
A 1 185 ARG 185 149 149 ARG ARG A . n 
A 1 186 GLU 186 150 150 GLU GLU A . n 
A 1 187 TRP 187 151 151 TRP TRP A . n 
A 1 188 TRP 188 152 152 TRP TRP A . n 
A 1 189 SER 189 153 153 SER SER A . n 
A 1 190 THR 190 154 154 THR THR A . n 
A 1 191 THR 191 155 155 THR THR A . n 
A 1 192 VAL 192 156 156 VAL VAL A . n 
A 1 193 ALA 193 157 157 ALA ALA A . n 
A 1 194 LYS 194 158 158 LYS LYS A . n 
A 1 195 GLY 195 159 159 GLY GLY A . n 
A 1 196 VAL 196 160 160 VAL VAL A . n 
A 1 197 ALA 197 161 161 ALA ALA A . n 
A 1 198 GLU 198 162 162 GLU GLU A . n 
A 1 199 SER 199 163 163 SER SER A . n 
A 1 200 GLY 200 164 164 GLY GLY A . n 
A 1 201 CYS 201 165 165 CYS CYS A . n 
A 1 202 ASP 202 166 166 ASP ASP A . n 
A 1 203 GLY 203 167 167 GLY GLY A . n 
A 1 204 ALA 204 168 168 ALA ALA A . n 
A 1 205 PHE 205 169 169 PHE PHE A . n 
A 1 206 ILE 206 170 170 ILE ILE A . n 
A 1 207 ASP 207 171 171 ASP ASP A . n 
A 1 208 GLN 208 172 172 GLN GLN A . n 
A 1 209 MET 209 173 173 MET MET A . n 
A 1 210 HIS 210 174 174 HIS HIS A . n 
A 1 211 GLY 211 175 175 GLY GLY A . n 
A 1 212 PHE 212 176 176 PHE PHE A . n 
A 1 213 ALA 213 177 177 ALA ALA A . n 
A 1 214 TRP 214 178 178 TRP TRP A . n 
A 1 215 LEU 215 179 179 LEU LEU A . n 
A 1 216 ARG 216 180 180 ARG ARG A . n 
A 1 217 ALA 217 181 181 ALA ALA A . n 
A 1 218 ASP 218 182 182 ASP ASP A . n 
A 1 219 LYS 219 183 183 LYS LYS A . n 
A 1 220 SER 220 184 184 SER SER A . n 
A 1 221 GLU 221 185 185 GLU GLU A . n 
A 1 222 ASP 222 186 186 ASP ASP A . n 
A 1 223 VAL 223 187 187 VAL VAL A . n 
A 1 224 GLN 224 188 188 GLN GLN A . n 
A 1 225 LYS 225 189 189 LYS LYS A . n 
A 1 226 ALA 226 190 190 ALA ALA A . n 
A 1 227 MET 227 191 191 MET MET A . n 
A 1 228 GLY 228 192 192 GLY GLY A . n 
A 1 229 GLU 229 193 193 GLU GLU A . n 
A 1 230 MET 230 194 194 MET MET A . n 
A 1 231 MET 231 195 195 MET MET A . n 
A 1 232 ALA 232 196 196 ALA ALA A . n 
A 1 233 LEU 233 197 197 LEU LEU A . n 
A 1 234 LEU 234 198 198 LEU LEU A . n 
A 1 235 LYS 235 199 199 LYS LYS A . n 
A 1 236 ARG 236 200 200 ARG ARG A . n 
A 1 237 LYS 237 201 201 LYS LYS A . n 
A 1 238 MET 238 202 202 MET MET A . n 
A 1 239 GLY 239 203 203 GLY GLY A . n 
A 1 240 PRO 240 204 204 PRO PRO A . n 
A 1 241 ASP 241 205 205 ASP ASP A . n 
A 1 242 LYS 242 206 206 LYS LYS A . n 
A 1 243 ILE 243 207 207 ILE ILE A . n 
A 1 244 LEU 244 208 208 LEU LEU A . n 
A 1 245 LEU 245 209 209 LEU LEU A . n 
A 1 246 GLY 246 210 210 GLY GLY A . n 
A 1 247 ASN 247 211 211 ASN ASN A . n 
A 1 248 ASN 248 212 212 ASN ASN A . n 
A 1 249 ALA 249 213 213 ALA ALA A . n 
A 1 250 ASN 250 214 214 ASN ASN A . n 
A 1 251 GLN 251 215 215 GLN GLN A . n 
A 1 252 ASP 252 216 216 ASP ASP A . n 
A 1 253 ILE 253 217 217 ILE ILE A . n 
A 1 254 ALA 254 218 218 ALA ALA A . n 
A 1 255 LYS 255 219 219 LYS LYS A . n 
A 1 256 ASP 256 220 220 ASP ASP A . n 
A 1 257 ALA 257 221 221 ALA ALA A . n 
A 1 258 PHE 258 222 222 PHE PHE A . n 
A 1 259 PRO 259 223 223 PRO PRO A . n 
A 1 260 VAL 260 224 224 VAL VAL A . n 
A 1 261 MET 261 225 225 MET MET A . n 
A 1 262 ASP 262 226 226 ASP ASP A . n 
A 1 263 ALA 263 227 227 ALA ALA A . n 
A 1 264 SER 264 228 228 SER SER A . n 
A 1 265 MET 265 229 229 MET MET A . n 
A 1 266 PHE 266 230 230 PHE PHE A . n 
A 1 267 GLU 267 231 231 GLU GLU A . n 
A 1 268 HIS 268 232 232 HIS HIS A . n 
A 1 269 TYR 269 233 233 TYR TYR A . n 
A 1 270 ASN 270 234 234 ASN ASN A . n 
A 1 271 GLU 271 235 235 GLU GLU A . n 
A 1 272 LYS 272 236 236 LYS LYS A . n 
A 1 273 LEU 273 237 237 LEU LEU A . n 
A 1 274 LEU 274 238 238 LEU LEU A . n 
A 1 275 SER 275 239 239 SER SER A . n 
A 1 276 LYS 276 240 240 LYS LYS A . n 
A 1 277 GLU 277 241 241 GLU GLU A . n 
A 1 278 SER 278 242 242 SER SER A . n 
A 1 279 LEU 279 243 243 LEU LEU A . n 
A 1 280 LEU 280 244 244 LEU LEU A . n 
A 1 281 GLN 281 245 245 GLN GLN A . n 
A 1 282 ASP 282 246 246 ASP ASP A . n 
A 1 283 TRP 283 247 247 TRP TRP A . n 
A 1 284 ASP 284 248 248 ASP ASP A . n 
A 1 285 ASP 285 249 249 ASP ASP A . n 
A 1 286 MET 286 250 250 MET MET A . n 
A 1 287 LEU 287 251 251 LEU LEU A . n 
A 1 288 ARG 288 252 252 ARG ARG A . n 
A 1 289 ILE 289 253 253 ILE ILE A . n 
A 1 290 ALA 290 254 254 ALA ALA A . n 
A 1 291 GLN 291 255 255 GLN GLN A . n 
A 1 292 ALA 292 256 256 ALA ALA A . n 
A 1 293 GLY 293 257 257 GLY GLY A . n 
A 1 294 LYS 294 258 258 LYS LYS A . n 
A 1 295 MET 295 259 259 MET MET A . n 
A 1 296 SER 296 260 260 SER SER A . n 
A 1 297 ILE 297 261 261 ILE ILE A . n 
A 1 298 PHE 298 262 262 PHE PHE A . n 
A 1 299 ARG 299 263 263 ARG ARG A . n 
A 1 300 ILE 300 264 264 ILE ILE A . n 
A 1 301 GLY 301 265 265 GLY GLY A . n 
A 1 302 VAL 302 266 266 VAL VAL A . n 
A 1 303 GLU 303 267 267 GLU GLU A . n 
A 1 304 SER 304 268 268 SER SER A . n 
A 1 305 ASP 305 269 269 ASP ASP A . n 
A 1 306 PRO 306 270 270 PRO PRO A . n 
A 1 307 ARG 307 271 271 ARG ARG A . n 
A 1 308 ALA 308 272 ?   ?   ?   A . n 
A 1 309 SER 309 273 ?   ?   ?   A . n 
A 1 310 GLN 310 274 ?   ?   ?   A . n 
A 1 311 ASP 311 275 ?   ?   ?   A . n 
A 1 312 GLN 312 276 ?   ?   ?   A . n 
A 1 313 GLY 313 277 ?   ?   ?   A . n 
A 1 314 ARG 314 278 ?   ?   ?   A . n 
A 1 315 ARG 315 279 ?   ?   ?   A . n 
A 1 316 GLY 316 280 ?   ?   ?   A . n 
A 1 317 SER 317 281 ?   ?   ?   A . n 
A 1 318 ARG 318 282 ?   ?   ?   A . n 
A 1 319 ARG 319 283 ?   ?   ?   A . n 
A 1 320 ASP 320 284 284 ASP ASP A . n 
A 1 321 GLN 321 285 285 GLN GLN A . n 
A 1 322 PRO 322 286 286 PRO PRO A . n 
A 1 323 VAL 323 287 287 VAL VAL A . n 
A 1 324 LEU 324 288 288 LEU LEU A . n 
A 1 325 ALA 325 289 289 ALA ALA A . n 
A 1 326 LYS 326 290 290 LYS LYS A . n 
A 1 327 GLU 327 291 291 GLU GLU A . n 
A 1 328 ARG 328 292 292 ARG ARG A . n 
A 1 329 ALA 329 293 293 ALA ALA A . n 
A 1 330 GLU 330 294 294 GLU GLU A . n 
A 1 331 TYR 331 295 295 TYR TYR A . n 
A 1 332 TYR 332 296 296 TYR TYR A . n 
A 1 333 LEU 333 297 297 LEU LEU A . n 
A 1 334 ALA 334 298 298 ALA ALA A . n 
A 1 335 CYS 335 299 299 CYS CYS A . n 
A 1 336 TYR 336 300 300 TYR TYR A . n 
A 1 337 LEU 337 301 301 LEU LEU A . n 
A 1 338 ILE 338 302 302 ILE ILE A . n 
A 1 339 GLY 339 303 303 GLY GLY A . n 
A 1 340 ALA 340 304 304 ALA ALA A . n 
A 1 341 GLN 341 305 305 GLN GLN A . n 
A 1 342 PRO 342 306 306 PRO PRO A . n 
A 1 343 TYR 343 307 307 TYR TYR A . n 
A 1 344 SER 344 308 308 SER SER A . n 
A 1 345 TYR 345 309 309 TYR TYR A . n 
A 1 346 PHE 346 310 310 PHE PHE A . n 
A 1 347 GLN 347 311 311 GLN GLN A . n 
A 1 348 TYR 348 312 312 TYR TYR A . n 
A 1 349 GLY 349 313 313 GLY GLY A . n 
A 1 350 TRP 350 314 314 TRP TRP A . n 
A 1 351 GLY 351 315 315 GLY GLY A . n 
A 1 352 TRP 352 316 316 TRP TRP A . n 
A 1 353 THR 353 317 317 THR THR A . n 
A 1 354 LEU 354 318 318 LEU LEU A . n 
A 1 355 SER 355 319 319 SER SER A . n 
A 1 356 SER 356 320 320 SER SER A . n 
A 1 357 GLY 357 321 321 GLY GLY A . n 
A 1 358 SER 358 322 322 SER SER A . n 
A 1 359 LEU 359 323 323 LEU LEU A . n 
A 1 360 HIS 360 324 324 HIS HIS A . n 
A 1 361 GLU 361 325 325 GLU GLU A . n 
A 1 362 PHE 362 326 326 PHE PHE A . n 
A 1 363 PRO 363 327 327 PRO PRO A . n 
A 1 364 GLU 364 328 328 GLU GLU A . n 
A 1 365 LEU 365 329 329 LEU LEU A . n 
A 1 366 ARG 366 330 330 ARG ARG A . n 
A 1 367 LYS 367 331 331 LYS LYS A . n 
A 1 368 ALA 368 332 332 ALA ALA A . n 
A 1 369 LEU 369 333 333 LEU LEU A . n 
A 1 370 GLY 370 334 334 GLY GLY A . n 
A 1 371 PRO 371 335 335 PRO PRO A . n 
A 1 372 PRO 372 336 336 PRO PRO A . n 
A 1 373 LYS 373 337 337 LYS LYS A . n 
A 1 374 GLY 374 338 338 GLY GLY A . n 
A 1 375 ALA 375 339 339 ALA ALA A . n 
A 1 376 TYR 376 340 340 TYR TYR A . n 
A 1 377 ASP 377 341 341 ASP ASP A . n 
A 1 378 ARG 378 342 342 ARG ARG A . n 
A 1 379 THR 379 343 343 THR THR A . n 
A 1 380 THR 380 344 344 THR THR A . n 
A 1 381 PRO 381 345 345 PRO PRO A . n 
A 1 382 ASP 382 346 346 ASP ASP A . n 
A 1 383 GLY 383 347 347 GLY GLY A . n 
A 1 384 TRP 384 348 348 TRP TRP A . n 
A 1 385 GLU 385 349 349 GLU GLU A . n 
A 1 386 PHE 386 350 350 PHE PHE A . n 
A 1 387 THR 387 351 351 THR THR A . n 
A 1 388 ARG 388 352 352 ARG ARG A . n 
A 1 389 GLU 389 353 353 GLU GLU A . n 
A 1 390 PHE 390 354 354 PHE PHE A . n 
A 1 391 GLU 391 355 355 GLU GLU A . n 
A 1 392 HIS 392 356 356 HIS HIS A . n 
A 1 393 ALA 393 357 357 ALA ALA A . n 
A 1 394 SER 394 358 358 SER SER A . n 
A 1 395 VAL 395 359 359 VAL VAL A . n 
A 1 396 TRP 396 360 360 TRP TRP A . n 
A 1 397 VAL 397 361 361 VAL VAL A . n 
A 1 398 ASN 398 362 362 ASN ASN A . n 
A 1 399 THR 399 363 363 THR THR A . n 
A 1 400 GLU 400 364 364 GLU GLU A . n 
A 1 401 THR 401 365 365 THR THR A . n 
A 1 402 GLY 402 366 366 GLY GLY A . n 
A 1 403 ASN 403 367 367 ASN ASN A . n 
A 1 404 ALA 404 368 368 ALA ALA A . n 
A 1 405 LYS 405 369 369 LYS LYS A . n 
A 1 406 ILE 406 370 370 ILE ILE A . n 
A 1 407 THR 407 371 371 THR THR A . n 
A 1 408 TRP 408 372 372 TRP TRP A . n 
A 1 409 ARG 409 373 373 ARG ARG A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 HOH 1   401 377 HOH HOH A . 
B 2 HOH 2   402 374 HOH HOH A . 
B 2 HOH 3   403 380 HOH HOH A . 
B 2 HOH 4   404 101 HOH HOH A . 
B 2 HOH 5   405 230 HOH HOH A . 
B 2 HOH 6   406 184 HOH HOH A . 
B 2 HOH 7   407 267 HOH HOH A . 
B 2 HOH 8   408 212 HOH HOH A . 
B 2 HOH 9   409 213 HOH HOH A . 
B 2 HOH 10  410 81  HOH HOH A . 
B 2 HOH 11  411 38  HOH HOH A . 
B 2 HOH 12  412 429 HOH HOH A . 
B 2 HOH 13  413 421 HOH HOH A . 
B 2 HOH 14  414 410 HOH HOH A . 
B 2 HOH 15  415 367 HOH HOH A . 
B 2 HOH 16  416 352 HOH HOH A . 
B 2 HOH 17  417 205 HOH HOH A . 
B 2 HOH 18  418 225 HOH HOH A . 
B 2 HOH 19  419 165 HOH HOH A . 
B 2 HOH 20  420 193 HOH HOH A . 
B 2 HOH 21  421 350 HOH HOH A . 
B 2 HOH 22  422 115 HOH HOH A . 
B 2 HOH 23  423 137 HOH HOH A . 
B 2 HOH 24  424 439 HOH HOH A . 
B 2 HOH 25  425 424 HOH HOH A . 
B 2 HOH 26  426 170 HOH HOH A . 
B 2 HOH 27  427 252 HOH HOH A . 
B 2 HOH 28  428 114 HOH HOH A . 
B 2 HOH 29  429 326 HOH HOH A . 
B 2 HOH 30  430 154 HOH HOH A . 
B 2 HOH 31  431 71  HOH HOH A . 
B 2 HOH 32  432 360 HOH HOH A . 
B 2 HOH 33  433 150 HOH HOH A . 
B 2 HOH 34  434 278 HOH HOH A . 
B 2 HOH 35  435 354 HOH HOH A . 
B 2 HOH 36  436 90  HOH HOH A . 
B 2 HOH 37  437 196 HOH HOH A . 
B 2 HOH 38  438 365 HOH HOH A . 
B 2 HOH 39  439 35  HOH HOH A . 
B 2 HOH 40  440 258 HOH HOH A . 
B 2 HOH 41  441 140 HOH HOH A . 
B 2 HOH 42  442 131 HOH HOH A . 
B 2 HOH 43  443 276 HOH HOH A . 
B 2 HOH 44  444 63  HOH HOH A . 
B 2 HOH 45  445 57  HOH HOH A . 
B 2 HOH 46  446 232 HOH HOH A . 
B 2 HOH 47  447 344 HOH HOH A . 
B 2 HOH 48  448 85  HOH HOH A . 
B 2 HOH 49  449 10  HOH HOH A . 
B 2 HOH 50  450 294 HOH HOH A . 
B 2 HOH 51  451 192 HOH HOH A . 
B 2 HOH 52  452 388 HOH HOH A . 
B 2 HOH 53  453 338 HOH HOH A . 
B 2 HOH 54  454 22  HOH HOH A . 
B 2 HOH 55  455 7   HOH HOH A . 
B 2 HOH 56  456 433 HOH HOH A . 
B 2 HOH 57  457 211 HOH HOH A . 
B 2 HOH 58  458 146 HOH HOH A . 
B 2 HOH 59  459 158 HOH HOH A . 
B 2 HOH 60  460 200 HOH HOH A . 
B 2 HOH 61  461 19  HOH HOH A . 
B 2 HOH 62  462 6   HOH HOH A . 
B 2 HOH 63  463 284 HOH HOH A . 
B 2 HOH 64  464 256 HOH HOH A . 
B 2 HOH 65  465 9   HOH HOH A . 
B 2 HOH 66  466 250 HOH HOH A . 
B 2 HOH 67  467 108 HOH HOH A . 
B 2 HOH 68  468 277 HOH HOH A . 
B 2 HOH 69  469 111 HOH HOH A . 
B 2 HOH 70  470 110 HOH HOH A . 
B 2 HOH 71  471 287 HOH HOH A . 
B 2 HOH 72  472 37  HOH HOH A . 
B 2 HOH 73  473 96  HOH HOH A . 
B 2 HOH 74  474 118 HOH HOH A . 
B 2 HOH 75  475 88  HOH HOH A . 
B 2 HOH 76  476 23  HOH HOH A . 
B 2 HOH 77  477 124 HOH HOH A . 
B 2 HOH 78  478 216 HOH HOH A . 
B 2 HOH 79  479 82  HOH HOH A . 
B 2 HOH 80  480 403 HOH HOH A . 
B 2 HOH 81  481 171 HOH HOH A . 
B 2 HOH 82  482 79  HOH HOH A . 
B 2 HOH 83  483 226 HOH HOH A . 
B 2 HOH 84  484 343 HOH HOH A . 
B 2 HOH 85  485 61  HOH HOH A . 
B 2 HOH 86  486 397 HOH HOH A . 
B 2 HOH 87  487 53  HOH HOH A . 
B 2 HOH 88  488 254 HOH HOH A . 
B 2 HOH 89  489 285 HOH HOH A . 
B 2 HOH 90  490 73  HOH HOH A . 
B 2 HOH 91  491 135 HOH HOH A . 
B 2 HOH 92  492 40  HOH HOH A . 
B 2 HOH 93  493 434 HOH HOH A . 
B 2 HOH 94  494 152 HOH HOH A . 
B 2 HOH 95  495 259 HOH HOH A . 
B 2 HOH 96  496 304 HOH HOH A . 
B 2 HOH 97  497 31  HOH HOH A . 
B 2 HOH 98  498 92  HOH HOH A . 
B 2 HOH 99  499 260 HOH HOH A . 
B 2 HOH 100 500 20  HOH HOH A . 
B 2 HOH 101 501 134 HOH HOH A . 
B 2 HOH 102 502 157 HOH HOH A . 
B 2 HOH 103 503 56  HOH HOH A . 
B 2 HOH 104 504 58  HOH HOH A . 
B 2 HOH 105 505 181 HOH HOH A . 
B 2 HOH 106 506 72  HOH HOH A . 
B 2 HOH 107 507 91  HOH HOH A . 
B 2 HOH 108 508 383 HOH HOH A . 
B 2 HOH 109 509 17  HOH HOH A . 
B 2 HOH 110 510 242 HOH HOH A . 
B 2 HOH 111 511 386 HOH HOH A . 
B 2 HOH 112 512 21  HOH HOH A . 
B 2 HOH 113 513 4   HOH HOH A . 
B 2 HOH 114 514 2   HOH HOH A . 
B 2 HOH 115 515 102 HOH HOH A . 
B 2 HOH 116 516 109 HOH HOH A . 
B 2 HOH 117 517 257 HOH HOH A . 
B 2 HOH 118 518 75  HOH HOH A . 
B 2 HOH 119 519 64  HOH HOH A . 
B 2 HOH 120 520 229 HOH HOH A . 
B 2 HOH 121 521 98  HOH HOH A . 
B 2 HOH 122 522 144 HOH HOH A . 
B 2 HOH 123 523 442 HOH HOH A . 
B 2 HOH 124 524 164 HOH HOH A . 
B 2 HOH 125 525 30  HOH HOH A . 
B 2 HOH 126 526 300 HOH HOH A . 
B 2 HOH 127 527 69  HOH HOH A . 
B 2 HOH 128 528 419 HOH HOH A . 
B 2 HOH 129 529 46  HOH HOH A . 
B 2 HOH 130 530 100 HOH HOH A . 
B 2 HOH 131 531 322 HOH HOH A . 
B 2 HOH 132 532 54  HOH HOH A . 
B 2 HOH 133 533 113 HOH HOH A . 
B 2 HOH 134 534 222 HOH HOH A . 
B 2 HOH 135 535 396 HOH HOH A . 
B 2 HOH 136 536 359 HOH HOH A . 
B 2 HOH 137 537 50  HOH HOH A . 
B 2 HOH 138 538 104 HOH HOH A . 
B 2 HOH 139 539 49  HOH HOH A . 
B 2 HOH 140 540 106 HOH HOH A . 
B 2 HOH 141 541 42  HOH HOH A . 
B 2 HOH 142 542 120 HOH HOH A . 
B 2 HOH 143 543 14  HOH HOH A . 
B 2 HOH 144 544 93  HOH HOH A . 
B 2 HOH 145 545 381 HOH HOH A . 
B 2 HOH 146 546 103 HOH HOH A . 
B 2 HOH 147 547 160 HOH HOH A . 
B 2 HOH 148 548 117 HOH HOH A . 
B 2 HOH 149 549 223 HOH HOH A . 
B 2 HOH 150 550 1   HOH HOH A . 
B 2 HOH 151 551 306 HOH HOH A . 
B 2 HOH 152 552 355 HOH HOH A . 
B 2 HOH 153 553 204 HOH HOH A . 
B 2 HOH 154 554 428 HOH HOH A . 
B 2 HOH 155 555 52  HOH HOH A . 
B 2 HOH 156 556 337 HOH HOH A . 
B 2 HOH 157 557 227 HOH HOH A . 
B 2 HOH 158 558 5   HOH HOH A . 
B 2 HOH 159 559 25  HOH HOH A . 
B 2 HOH 160 560 68  HOH HOH A . 
B 2 HOH 161 561 127 HOH HOH A . 
B 2 HOH 162 562 191 HOH HOH A . 
B 2 HOH 163 563 65  HOH HOH A . 
B 2 HOH 164 564 99  HOH HOH A . 
B 2 HOH 165 565 32  HOH HOH A . 
B 2 HOH 166 566 12  HOH HOH A . 
B 2 HOH 167 567 33  HOH HOH A . 
B 2 HOH 168 568 84  HOH HOH A . 
B 2 HOH 169 569 197 HOH HOH A . 
B 2 HOH 170 570 318 HOH HOH A . 
B 2 HOH 171 571 76  HOH HOH A . 
B 2 HOH 172 572 70  HOH HOH A . 
B 2 HOH 173 573 405 HOH HOH A . 
B 2 HOH 174 574 415 HOH HOH A . 
B 2 HOH 175 575 129 HOH HOH A . 
B 2 HOH 176 576 390 HOH HOH A . 
B 2 HOH 177 577 407 HOH HOH A . 
B 2 HOH 178 578 447 HOH HOH A . 
B 2 HOH 179 579 261 HOH HOH A . 
B 2 HOH 180 580 179 HOH HOH A . 
B 2 HOH 181 581 155 HOH HOH A . 
B 2 HOH 182 582 176 HOH HOH A . 
B 2 HOH 183 583 13  HOH HOH A . 
B 2 HOH 184 584 126 HOH HOH A . 
B 2 HOH 185 585 264 HOH HOH A . 
B 2 HOH 186 586 325 HOH HOH A . 
B 2 HOH 187 587 139 HOH HOH A . 
B 2 HOH 188 588 133 HOH HOH A . 
B 2 HOH 189 589 321 HOH HOH A . 
B 2 HOH 190 590 149 HOH HOH A . 
B 2 HOH 191 591 43  HOH HOH A . 
B 2 HOH 192 592 228 HOH HOH A . 
B 2 HOH 193 593 190 HOH HOH A . 
B 2 HOH 194 594 94  HOH HOH A . 
B 2 HOH 195 595 36  HOH HOH A . 
B 2 HOH 196 596 41  HOH HOH A . 
B 2 HOH 197 597 83  HOH HOH A . 
B 2 HOH 198 598 331 HOH HOH A . 
B 2 HOH 199 599 44  HOH HOH A . 
B 2 HOH 200 600 51  HOH HOH A . 
B 2 HOH 201 601 266 HOH HOH A . 
B 2 HOH 202 602 60  HOH HOH A . 
B 2 HOH 203 603 313 HOH HOH A . 
B 2 HOH 204 604 292 HOH HOH A . 
B 2 HOH 205 605 119 HOH HOH A . 
B 2 HOH 206 606 185 HOH HOH A . 
B 2 HOH 207 607 74  HOH HOH A . 
B 2 HOH 208 608 87  HOH HOH A . 
B 2 HOH 209 609 3   HOH HOH A . 
B 2 HOH 210 610 162 HOH HOH A . 
B 2 HOH 211 611 301 HOH HOH A . 
B 2 HOH 212 612 62  HOH HOH A . 
B 2 HOH 213 613 209 HOH HOH A . 
B 2 HOH 214 614 263 HOH HOH A . 
B 2 HOH 215 615 55  HOH HOH A . 
B 2 HOH 216 616 142 HOH HOH A . 
B 2 HOH 217 617 145 HOH HOH A . 
B 2 HOH 218 618 273 HOH HOH A . 
B 2 HOH 219 619 436 HOH HOH A . 
B 2 HOH 220 620 404 HOH HOH A . 
B 2 HOH 221 621 219 HOH HOH A . 
B 2 HOH 222 622 233 HOH HOH A . 
B 2 HOH 223 623 298 HOH HOH A . 
B 2 HOH 224 624 125 HOH HOH A . 
B 2 HOH 225 625 399 HOH HOH A . 
B 2 HOH 226 626 153 HOH HOH A . 
B 2 HOH 227 627 172 HOH HOH A . 
B 2 HOH 228 628 251 HOH HOH A . 
B 2 HOH 229 629 163 HOH HOH A . 
B 2 HOH 230 630 95  HOH HOH A . 
B 2 HOH 231 631 245 HOH HOH A . 
B 2 HOH 232 632 449 HOH HOH A . 
B 2 HOH 233 633 28  HOH HOH A . 
B 2 HOH 234 634 175 HOH HOH A . 
B 2 HOH 235 635 202 HOH HOH A . 
B 2 HOH 236 636 328 HOH HOH A . 
B 2 HOH 237 637 15  HOH HOH A . 
B 2 HOH 238 638 24  HOH HOH A . 
B 2 HOH 239 639 220 HOH HOH A . 
B 2 HOH 240 640 255 HOH HOH A . 
B 2 HOH 241 641 16  HOH HOH A . 
B 2 HOH 242 642 11  HOH HOH A . 
B 2 HOH 243 643 178 HOH HOH A . 
B 2 HOH 244 644 351 HOH HOH A . 
B 2 HOH 245 645 361 HOH HOH A . 
B 2 HOH 246 646 80  HOH HOH A . 
B 2 HOH 247 647 269 HOH HOH A . 
B 2 HOH 248 648 47  HOH HOH A . 
B 2 HOH 249 649 27  HOH HOH A . 
B 2 HOH 250 650 18  HOH HOH A . 
B 2 HOH 251 651 147 HOH HOH A . 
B 2 HOH 252 652 210 HOH HOH A . 
B 2 HOH 253 653 382 HOH HOH A . 
B 2 HOH 254 654 201 HOH HOH A . 
B 2 HOH 255 655 286 HOH HOH A . 
B 2 HOH 256 656 296 HOH HOH A . 
B 2 HOH 257 657 77  HOH HOH A . 
B 2 HOH 258 658 107 HOH HOH A . 
B 2 HOH 259 659 86  HOH HOH A . 
B 2 HOH 260 660 121 HOH HOH A . 
B 2 HOH 261 661 293 HOH HOH A . 
B 2 HOH 262 662 395 HOH HOH A . 
B 2 HOH 263 663 105 HOH HOH A . 
B 2 HOH 264 664 339 HOH HOH A . 
B 2 HOH 265 665 26  HOH HOH A . 
B 2 HOH 266 666 48  HOH HOH A . 
B 2 HOH 267 667 34  HOH HOH A . 
B 2 HOH 268 668 45  HOH HOH A . 
B 2 HOH 269 669 358 HOH HOH A . 
B 2 HOH 270 670 305 HOH HOH A . 
B 2 HOH 271 671 59  HOH HOH A . 
B 2 HOH 272 672 406 HOH HOH A . 
B 2 HOH 273 673 169 HOH HOH A . 
B 2 HOH 274 674 392 HOH HOH A . 
B 2 HOH 275 675 431 HOH HOH A . 
B 2 HOH 276 676 78  HOH HOH A . 
B 2 HOH 277 677 8   HOH HOH A . 
B 2 HOH 278 678 411 HOH HOH A . 
B 2 HOH 279 679 39  HOH HOH A . 
B 2 HOH 280 680 376 HOH HOH A . 
B 2 HOH 281 681 353 HOH HOH A . 
B 2 HOH 282 682 122 HOH HOH A . 
B 2 HOH 283 683 283 HOH HOH A . 
B 2 HOH 284 684 66  HOH HOH A . 
B 2 HOH 285 685 393 HOH HOH A . 
B 2 HOH 286 686 143 HOH HOH A . 
B 2 HOH 287 687 156 HOH HOH A . 
B 2 HOH 288 688 188 HOH HOH A . 
B 2 HOH 289 689 345 HOH HOH A . 
B 2 HOH 290 690 159 HOH HOH A . 
B 2 HOH 291 691 446 HOH HOH A . 
B 2 HOH 292 692 194 HOH HOH A . 
B 2 HOH 293 693 416 HOH HOH A . 
B 2 HOH 294 694 414 HOH HOH A . 
B 2 HOH 295 695 444 HOH HOH A . 
B 2 HOH 296 696 308 HOH HOH A . 
B 2 HOH 297 697 166 HOH HOH A . 
B 2 HOH 298 698 214 HOH HOH A . 
B 2 HOH 299 699 280 HOH HOH A . 
B 2 HOH 300 700 67  HOH HOH A . 
B 2 HOH 301 701 400 HOH HOH A . 
B 2 HOH 302 702 173 HOH HOH A . 
B 2 HOH 303 703 275 HOH HOH A . 
B 2 HOH 304 704 148 HOH HOH A . 
B 2 HOH 305 705 97  HOH HOH A . 
B 2 HOH 306 706 418 HOH HOH A . 
B 2 HOH 307 707 207 HOH HOH A . 
B 2 HOH 308 708 427 HOH HOH A . 
B 2 HOH 309 709 290 HOH HOH A . 
B 2 HOH 310 710 262 HOH HOH A . 
B 2 HOH 311 711 448 HOH HOH A . 
B 2 HOH 312 712 29  HOH HOH A . 
B 2 HOH 313 713 384 HOH HOH A . 
B 2 HOH 314 714 130 HOH HOH A . 
B 2 HOH 315 715 420 HOH HOH A . 
B 2 HOH 316 716 357 HOH HOH A . 
B 2 HOH 317 717 247 HOH HOH A . 
B 2 HOH 318 718 299 HOH HOH A . 
B 2 HOH 319 719 441 HOH HOH A . 
B 2 HOH 320 720 362 HOH HOH A . 
B 2 HOH 321 721 167 HOH HOH A . 
B 2 HOH 322 722 177 HOH HOH A . 
B 2 HOH 323 723 398 HOH HOH A . 
B 2 HOH 324 724 425 HOH HOH A . 
B 2 HOH 325 725 243 HOH HOH A . 
B 2 HOH 326 726 217 HOH HOH A . 
B 2 HOH 327 727 141 HOH HOH A . 
B 2 HOH 328 728 408 HOH HOH A . 
B 2 HOH 329 729 323 HOH HOH A . 
B 2 HOH 330 730 206 HOH HOH A . 
B 2 HOH 331 731 151 HOH HOH A . 
B 2 HOH 332 732 132 HOH HOH A . 
B 2 HOH 333 733 89  HOH HOH A . 
B 2 HOH 334 734 241 HOH HOH A . 
B 2 HOH 335 735 116 HOH HOH A . 
B 2 HOH 336 736 394 HOH HOH A . 
B 2 HOH 337 737 174 HOH HOH A . 
B 2 HOH 338 738 340 HOH HOH A . 
B 2 HOH 339 739 346 HOH HOH A . 
B 2 HOH 340 740 224 HOH HOH A . 
B 2 HOH 341 741 387 HOH HOH A . 
B 2 HOH 342 742 249 HOH HOH A . 
B 2 HOH 343 743 349 HOH HOH A . 
B 2 HOH 344 744 279 HOH HOH A . 
B 2 HOH 345 745 348 HOH HOH A . 
B 2 HOH 346 746 347 HOH HOH A . 
B 2 HOH 347 747 128 HOH HOH A . 
B 2 HOH 348 748 368 HOH HOH A . 
B 2 HOH 349 749 430 HOH HOH A . 
B 2 HOH 350 750 183 HOH HOH A . 
B 2 HOH 351 751 307 HOH HOH A . 
B 2 HOH 352 752 180 HOH HOH A . 
B 2 HOH 353 753 203 HOH HOH A . 
B 2 HOH 354 754 302 HOH HOH A . 
B 2 HOH 355 755 248 HOH HOH A . 
B 2 HOH 356 756 309 HOH HOH A . 
B 2 HOH 357 757 199 HOH HOH A . 
B 2 HOH 358 758 246 HOH HOH A . 
B 2 HOH 359 759 235 HOH HOH A . 
B 2 HOH 360 760 236 HOH HOH A . 
B 2 HOH 361 761 341 HOH HOH A . 
B 2 HOH 362 762 451 HOH HOH A . 
B 2 HOH 363 763 413 HOH HOH A . 
B 2 HOH 364 764 401 HOH HOH A . 
B 2 HOH 365 765 215 HOH HOH A . 
B 2 HOH 366 766 364 HOH HOH A . 
B 2 HOH 367 767 316 HOH HOH A . 
B 2 HOH 368 768 291 HOH HOH A . 
B 2 HOH 369 769 329 HOH HOH A . 
B 2 HOH 370 770 187 HOH HOH A . 
B 2 HOH 371 771 112 HOH HOH A . 
B 2 HOH 372 772 123 HOH HOH A . 
B 2 HOH 373 773 356 HOH HOH A . 
B 2 HOH 374 774 195 HOH HOH A . 
B 2 HOH 375 775 244 HOH HOH A . 
B 2 HOH 376 776 282 HOH HOH A . 
B 2 HOH 377 777 375 HOH HOH A . 
B 2 HOH 378 778 332 HOH HOH A . 
B 2 HOH 379 779 391 HOH HOH A . 
B 2 HOH 380 780 336 HOH HOH A . 
B 2 HOH 381 781 270 HOH HOH A . 
B 2 HOH 382 782 288 HOH HOH A . 
B 2 HOH 383 783 409 HOH HOH A . 
B 2 HOH 384 784 317 HOH HOH A . 
B 2 HOH 385 785 168 HOH HOH A . 
B 2 HOH 386 786 333 HOH HOH A . 
B 2 HOH 387 787 240 HOH HOH A . 
B 2 HOH 388 788 295 HOH HOH A . 
B 2 HOH 389 789 432 HOH HOH A . 
B 2 HOH 390 790 327 HOH HOH A . 
B 2 HOH 391 791 289 HOH HOH A . 
B 2 HOH 392 792 231 HOH HOH A . 
B 2 HOH 393 793 238 HOH HOH A . 
B 2 HOH 394 794 372 HOH HOH A . 
B 2 HOH 395 795 268 HOH HOH A . 
B 2 HOH 396 796 208 HOH HOH A . 
B 2 HOH 397 797 161 HOH HOH A . 
B 2 HOH 398 798 320 HOH HOH A . 
B 2 HOH 399 799 389 HOH HOH A . 
B 2 HOH 400 800 437 HOH HOH A . 
B 2 HOH 401 801 271 HOH HOH A . 
B 2 HOH 402 802 253 HOH HOH A . 
B 2 HOH 403 803 335 HOH HOH A . 
B 2 HOH 404 804 435 HOH HOH A . 
B 2 HOH 405 805 312 HOH HOH A . 
B 2 HOH 406 806 330 HOH HOH A . 
B 2 HOH 407 807 422 HOH HOH A . 
B 2 HOH 408 808 136 HOH HOH A . 
B 2 HOH 409 809 189 HOH HOH A . 
B 2 HOH 410 810 369 HOH HOH A . 
B 2 HOH 411 811 186 HOH HOH A . 
B 2 HOH 412 812 450 HOH HOH A . 
B 2 HOH 413 813 281 HOH HOH A . 
B 2 HOH 414 814 272 HOH HOH A . 
B 2 HOH 415 815 314 HOH HOH A . 
B 2 HOH 416 816 443 HOH HOH A . 
B 2 HOH 417 817 417 HOH HOH A . 
B 2 HOH 418 818 182 HOH HOH A . 
B 2 HOH 419 819 198 HOH HOH A . 
B 2 HOH 420 820 371 HOH HOH A . 
B 2 HOH 421 821 138 HOH HOH A . 
B 2 HOH 422 822 426 HOH HOH A . 
B 2 HOH 423 823 366 HOH HOH A . 
B 2 HOH 424 824 237 HOH HOH A . 
B 2 HOH 425 825 234 HOH HOH A . 
B 2 HOH 426 826 311 HOH HOH A . 
B 2 HOH 427 827 218 HOH HOH A . 
B 2 HOH 428 828 373 HOH HOH A . 
B 2 HOH 429 829 303 HOH HOH A . 
B 2 HOH 430 830 315 HOH HOH A . 
B 2 HOH 431 831 342 HOH HOH A . 
B 2 HOH 432 832 221 HOH HOH A . 
B 2 HOH 433 833 370 HOH HOH A . 
B 2 HOH 434 834 319 HOH HOH A . 
B 2 HOH 435 835 363 HOH HOH A . 
B 2 HOH 436 836 324 HOH HOH A . 
B 2 HOH 437 837 402 HOH HOH A . 
B 2 HOH 438 838 445 HOH HOH A . 
B 2 HOH 439 839 334 HOH HOH A . 
B 2 HOH 440 840 379 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A ASP 17  ? OD2 ? A ASP 53  OD2 
2  1 Y 1 A LYS 21  ? CD  ? A LYS 57  CD  
3  1 Y 1 A LYS 21  ? CE  ? A LYS 57  CE  
4  1 Y 1 A LYS 21  ? NZ  ? A LYS 57  NZ  
5  1 Y 1 A ARG 63  ? CG  ? A ARG 99  CG  
6  1 Y 1 A ARG 63  ? CD  ? A ARG 99  CD  
7  1 Y 1 A ARG 63  ? NE  ? A ARG 99  NE  
8  1 Y 1 A ARG 63  ? CZ  ? A ARG 99  CZ  
9  1 Y 1 A ARG 63  ? NH1 ? A ARG 99  NH1 
10 1 Y 1 A ARG 63  ? NH2 ? A ARG 99  NH2 
11 1 Y 1 A LYS 82  ? CG  ? A LYS 118 CG  
12 1 Y 1 A LYS 82  ? CD  ? A LYS 118 CD  
13 1 Y 1 A LYS 82  ? CE  ? A LYS 118 CE  
14 1 Y 1 A LYS 82  ? NZ  ? A LYS 118 NZ  
15 1 Y 1 A GLN 106 ? CD  ? A GLN 142 CD  
16 1 Y 1 A GLN 106 ? OE1 ? A GLN 142 OE1 
17 1 Y 1 A GLN 106 ? NE2 ? A GLN 142 NE2 
18 1 Y 1 A GLU 131 ? OE1 ? A GLU 167 OE1 
19 1 Y 1 A GLU 131 ? OE2 ? A GLU 167 OE2 
20 1 Y 1 A ASP 216 ? CB  ? A ASP 252 CB  
21 1 Y 1 A ASP 216 ? CG  ? A ASP 252 CG  
22 1 Y 1 A ASP 216 ? OD1 ? A ASP 252 OD1 
23 1 Y 1 A ASP 216 ? OD2 ? A ASP 252 OD2 
24 1 Y 1 A ILE 217 ? CB  ? A ILE 253 CB  
25 1 Y 1 A ILE 217 ? CG1 ? A ILE 253 CG1 
26 1 Y 1 A ILE 217 ? CG2 ? A ILE 253 CG2 
27 1 Y 1 A ILE 217 ? CD1 ? A ILE 253 CD1 
28 1 Y 1 A GLU 291 ? OE1 ? A GLU 327 OE1 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? '(1.20.1_4487: ???)' 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .                    2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .                    3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .                    4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9JOS 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     148.280 
_cell.length_a_esd                 ? 
_cell.length_b                     148.280 
_cell.length_b_esd                 ? 
_cell.length_c                     42.040 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        9 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9JOS 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                146 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'H 3' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9JOS 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             1.90 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          35.33 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.2 M Lithium sulfate monohydrate, 0.1 M Tris pH 8.5, 25% w/v Polyethylene glycol 3,350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            290 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS3 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-06-23 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97923 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL19U1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97923 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL19U1 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9JOS 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.70 
_reflns.d_resolution_low                               74.14 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     37521 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.0 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                9.1 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          20.4 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               0.95 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.084 
_reflns.pdbx_Rpim_I_all                                0.027 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       343059 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   1.000 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.079 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.70 
_reflns_shell.d_res_low                                     1.74 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2549 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               5.3 
_reflns_shell.pdbx_chi_squared                              0.86 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               1.193 
_reflns_shell.pdbx_Rpim_I_all                               0.505 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.624 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.075 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9JOS 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.70 
_refine.ls_d_res_low                             74.14 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     37516 
_refine.ls_number_reflns_R_free                  1994 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    98.97 
_refine.ls_percent_reflns_R_free                 5.32 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1682 
_refine.ls_R_factor_R_free                       0.2047 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1661 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.98 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.10 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 23.12 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.23 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.70 
_refine_hist.d_res_low                        74.14 
_refine_hist.number_atoms_solvent             440 
_refine_hist.number_atoms_total               3338 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2898 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.010 ? 2985 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.069 ? 4039 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 6.280 ? 391  ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.056 ? 408  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.010 ? 522  ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.70 1.74  . . 132 2343 91.00  . . . . 0.2961 . . . . . . . . . . . 0.3439 
'X-RAY DIFFRACTION' 1.74 1.79  . . 140 2445 97.00  . . . . 0.2748 . . . . . . . . . . . 0.3347 
'X-RAY DIFFRACTION' 1.79 1.84  . . 143 2516 98.00  . . . . 0.2298 . . . . . . . . . . . 0.2470 
'X-RAY DIFFRACTION' 1.84 1.90  . . 145 2560 100.00 . . . . 0.1959 . . . . . . . . . . . 0.2626 
'X-RAY DIFFRACTION' 1.90 1.97  . . 146 2576 100.00 . . . . 0.1999 . . . . . . . . . . . 0.2680 
'X-RAY DIFFRACTION' 1.97 2.05  . . 143 2550 100.00 . . . . 0.1886 . . . . . . . . . . . 0.2183 
'X-RAY DIFFRACTION' 2.05 2.14  . . 141 2576 100.00 . . . . 0.1748 . . . . . . . . . . . 0.2282 
'X-RAY DIFFRACTION' 2.14 2.25  . . 143 2563 100.00 . . . . 0.1575 . . . . . . . . . . . 0.2321 
'X-RAY DIFFRACTION' 2.25 2.40  . . 143 2560 100.00 . . . . 0.1704 . . . . . . . . . . . 0.2196 
'X-RAY DIFFRACTION' 2.40 2.58  . . 140 2566 100.00 . . . . 0.1575 . . . . . . . . . . . 0.1650 
'X-RAY DIFFRACTION' 2.58 2.84  . . 146 2577 100.00 . . . . 0.1747 . . . . . . . . . . . 0.2087 
'X-RAY DIFFRACTION' 2.84 3.25  . . 143 2571 100.00 . . . . 0.1575 . . . . . . . . . . . 0.2211 
'X-RAY DIFFRACTION' 3.25 4.09  . . 146 2562 100.00 . . . . 0.1463 . . . . . . . . . . . 0.1633 
'X-RAY DIFFRACTION' 4.10 74.14 . . 143 2557 100.00 . . . . 0.1408 . . . . . . . . . . . 0.1756 
# 
_struct.entry_id                     9JOS 
_struct.title                        'STRUCTURE OF ENDO-1,3-FUCANASE FROM GH168 FAMILY' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9JOS 
_struct_keywords.text            'Endo-1.3-fucanase, GH168, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A0A5C6D8T6_9BACT 
_struct_ref.pdbx_db_accession          A0A5C6D8T6 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;LGQHYLNSDGSRFVPKDFYPKFSWDTTPMYYMFGDTTRLLEPEEVEFIAERTDFLCIEKSHGRTPLGAAELGAKHEAAAF
KKIKPDMKVLFYFNSAYAWPFTSYNQAFTRNKIDEHPKLKSFLIVDPKTAELAHRRNVFFFDVLNPELREWWSTTVAKGV
AESGCDGAFIDQMHGFAWLRADKSEDVQKAMGEMMALLKRKMGPDKILLGNNANQDIAKDAFPVMDASMFEHYNEKLLSK
ESLLQDWDDMLRIAQAGKMSIFRIGVESDPRASQDQGRRGSRRDQPVLAKERAEYYLACYLIGAQPYSYFQYGWGWTLSS
GSLHEFPELRKALGPPKGAYDRTTPDGWEFTREFEHASVWVNTETGNAKITWR
;
_struct_ref.pdbx_align_begin           23 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9JOS 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 37 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 409 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             A0A5C6D8T6 
_struct_ref_seq.db_align_beg                  23 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  395 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       373 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9JOS MET A 1  ? UNP A0A5C6D8T6 ? ? 'initiating methionine' -35 1  
1 9JOS GLY A 2  ? UNP A0A5C6D8T6 ? ? 'expression tag'        -34 2  
1 9JOS SER A 3  ? UNP A0A5C6D8T6 ? ? 'expression tag'        -33 3  
1 9JOS SER A 4  ? UNP A0A5C6D8T6 ? ? 'expression tag'        -32 4  
1 9JOS HIS A 5  ? UNP A0A5C6D8T6 ? ? 'expression tag'        -31 5  
1 9JOS HIS A 6  ? UNP A0A5C6D8T6 ? ? 'expression tag'        -30 6  
1 9JOS HIS A 7  ? UNP A0A5C6D8T6 ? ? 'expression tag'        -29 7  
1 9JOS HIS A 8  ? UNP A0A5C6D8T6 ? ? 'expression tag'        -28 8  
1 9JOS HIS A 9  ? UNP A0A5C6D8T6 ? ? 'expression tag'        -27 9  
1 9JOS HIS A 10 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -26 10 
1 9JOS SER A 11 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -25 11 
1 9JOS SER A 12 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -24 12 
1 9JOS GLY A 13 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -23 13 
1 9JOS LEU A 14 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -22 14 
1 9JOS VAL A 15 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -21 15 
1 9JOS PRO A 16 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -20 16 
1 9JOS ARG A 17 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -19 17 
1 9JOS GLY A 18 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -18 18 
1 9JOS SER A 19 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -17 19 
1 9JOS HIS A 20 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -16 20 
1 9JOS MET A 21 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -15 21 
1 9JOS ALA A 22 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -14 22 
1 9JOS SER A 23 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -13 23 
1 9JOS MET A 24 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -12 24 
1 9JOS THR A 25 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -11 25 
1 9JOS GLY A 26 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -10 26 
1 9JOS GLY A 27 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -9  27 
1 9JOS GLN A 28 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -8  28 
1 9JOS GLN A 29 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -7  29 
1 9JOS MET A 30 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -6  30 
1 9JOS GLY A 31 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -5  31 
1 9JOS ARG A 32 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -4  32 
1 9JOS GLY A 33 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -3  33 
1 9JOS SER A 34 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -2  34 
1 9JOS GLU A 35 ? UNP A0A5C6D8T6 ? ? 'expression tag'        -1  35 
1 9JOS PHE A 36 ? UNP A0A5C6D8T6 ? ? 'expression tag'        0   36 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLU A 77  ? THR A 88  ? GLU A 41  THR A 52  1 ? 12 
HELX_P HELX_P2  AA2 GLY A 98  ? GLY A 103 ? GLY A 62  GLY A 67  1 ? 6  
HELX_P HELX_P3  AA3 ALA A 104 ? LYS A 120 ? ALA A 68  LYS A 84  1 ? 17 
HELX_P HELX_P4  AA4 THR A 138 ? GLN A 142 ? THR A 102 GLN A 106 5 ? 5  
HELX_P HELX_P5  AA5 LYS A 148 ? GLU A 151 ? LYS A 112 GLU A 115 5 ? 4  
HELX_P HELX_P6  AA6 HIS A 152 ? SER A 157 ? HIS A 116 SER A 121 1 ? 6  
HELX_P HELX_P7  AA7 ASN A 181 ? GLY A 200 ? ASN A 145 GLY A 164 1 ? 20 
HELX_P HELX_P8  AA8 PHE A 212 ? ASP A 218 ? PHE A 176 ASP A 182 5 ? 7  
HELX_P HELX_P9  AA9 LYS A 219 ? GLY A 239 ? LYS A 183 GLY A 203 1 ? 21 
HELX_P HELX_P10 AB1 GLN A 251 ? LYS A 255 ? GLN A 215 LYS A 219 5 ? 5  
HELX_P HELX_P11 AB2 ALA A 257 ? MET A 261 ? ALA A 221 MET A 225 5 ? 5  
HELX_P HELX_P12 AB3 GLU A 271 ? LEU A 274 ? GLU A 235 LEU A 238 5 ? 4  
HELX_P HELX_P13 AB4 SER A 275 ? ALA A 292 ? SER A 239 ALA A 256 1 ? 18 
HELX_P HELX_P14 AB5 GLU A 303 ? ASP A 305 ? GLU A 267 ASP A 269 5 ? 3  
HELX_P HELX_P15 AB6 GLN A 321 ? ALA A 340 ? GLN A 285 ALA A 304 1 ? 20 
HELX_P HELX_P16 AB7 PHE A 362 ? LYS A 367 ? PHE A 326 LYS A 331 5 ? 6  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 8 ? 
AA2 ? 2 ? 
AA3 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? parallel      
AA1 3 4 ? parallel      
AA1 4 5 ? parallel      
AA1 5 6 ? parallel      
AA1 6 7 ? parallel      
AA1 7 8 ? parallel      
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 TYR A 67  ? PHE A 69  ? TYR A 31  PHE A 33  
AA1 2 PHE A 90  ? ILE A 93  ? PHE A 54  ILE A 57  
AA1 3 LYS A 124 ? ASN A 130 ? LYS A 88  ASN A 94  
AA1 4 GLY A 203 ? ASP A 207 ? GLY A 167 ASP A 171 
AA1 5 ILE A 243 ? ASN A 247 ? ILE A 207 ASN A 211 
AA1 6 ALA A 263 ? PHE A 266 ? ALA A 227 PHE A 230 
AA1 7 MET A 295 ? GLY A 301 ? MET A 259 GLY A 265 
AA1 8 SER A 344 ? GLY A 349 ? SER A 308 GLY A 313 
AA2 1 HIS A 170 ? ARG A 171 ? HIS A 134 ARG A 135 
AA2 2 VAL A 174 ? PHE A 175 ? VAL A 138 PHE A 139 
AA3 1 ASP A 377 ? ARG A 378 ? ASP A 341 ARG A 342 
AA3 2 GLU A 385 ? PHE A 390 ? GLU A 349 PHE A 354 
AA3 3 ALA A 393 ? ASN A 398 ? ALA A 357 ASN A 362 
AA3 4 ASN A 403 ? TRP A 408 ? ASN A 367 TRP A 372 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N TYR A 67  ? N TYR A 31  O CYS A 92  ? O CYS A 56  
AA1 2 3 N LEU A 91  ? N LEU A 55  O LYS A 124 ? O LYS A 88  
AA1 3 4 N PHE A 127 ? N PHE A 91  O GLY A 203 ? O GLY A 167 
AA1 4 5 N ILE A 206 ? N ILE A 170 O LEU A 245 ? O LEU A 209 
AA1 5 6 N GLY A 246 ? N GLY A 210 O ALA A 263 ? O ALA A 227 
AA1 6 7 N PHE A 266 ? N PHE A 230 O ILE A 297 ? O ILE A 261 
AA1 7 8 N PHE A 298 ? N PHE A 262 O TYR A 345 ? O TYR A 309 
AA2 1 2 N ARG A 171 ? N ARG A 135 O VAL A 174 ? O VAL A 138 
AA3 1 2 N ASP A 377 ? N ASP A 341 O THR A 387 ? O THR A 351 
AA3 2 3 N PHE A 390 ? N PHE A 354 O ALA A 393 ? O ALA A 357 
AA3 3 4 N SER A 394 ? N SER A 358 O THR A 407 ? O THR A 371 
# 
_pdbx_entry_details.entry_id                   9JOS 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 HH22 A ARG 110 ? ? O   A HOH 403 ? ? 1.43 
2 1 HE2  A HIS 232 ? ? OD2 A ASP 246 ? ? 1.56 
3 1 O    A HOH 486 ? ? O   A HOH 706 ? ? 1.95 
4 1 O    A HOH 435 ? ? O   A HOH 632 ? ? 2.05 
5 1 O    A HOH 708 ? ? O   A HOH 724 ? ? 2.06 
6 1 O    A HOH 434 ? ? O   A HOH 536 ? ? 2.08 
7 1 O    A HOH 471 ? ? O   A HOH 769 ? ? 2.09 
8 1 O    A HOH 443 ? ? O   A HOH 812 ? ? 2.14 
9 1 NZ   A LYS 258 ? ? O   A HOH 401 ? ? 2.17 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    O 
_pdbx_validate_symm_contact.auth_asym_id_1    A 
_pdbx_validate_symm_contact.auth_comp_id_1    HOH 
_pdbx_validate_symm_contact.auth_seq_id_1     783 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    O 
_pdbx_validate_symm_contact.auth_asym_id_2    A 
_pdbx_validate_symm_contact.auth_comp_id_2    HOH 
_pdbx_validate_symm_contact.auth_seq_id_2     831 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   1_554 
_pdbx_validate_symm_contact.dist              2.08 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 PRO A 100 ? ? -88.25 38.64  
2 1 GLN A 172 ? ? 80.74  131.69 
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      A 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       840 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   5.95 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET -35 ? A MET 1   
2  1 Y 1 A GLY -34 ? A GLY 2   
3  1 Y 1 A SER -33 ? A SER 3   
4  1 Y 1 A SER -32 ? A SER 4   
5  1 Y 1 A HIS -31 ? A HIS 5   
6  1 Y 1 A HIS -30 ? A HIS 6   
7  1 Y 1 A HIS -29 ? A HIS 7   
8  1 Y 1 A HIS -28 ? A HIS 8   
9  1 Y 1 A HIS -27 ? A HIS 9   
10 1 Y 1 A HIS -26 ? A HIS 10  
11 1 Y 1 A SER -25 ? A SER 11  
12 1 Y 1 A SER -24 ? A SER 12  
13 1 Y 1 A GLY -23 ? A GLY 13  
14 1 Y 1 A LEU -22 ? A LEU 14  
15 1 Y 1 A VAL -21 ? A VAL 15  
16 1 Y 1 A PRO -20 ? A PRO 16  
17 1 Y 1 A ARG -19 ? A ARG 17  
18 1 Y 1 A GLY -18 ? A GLY 18  
19 1 Y 1 A SER -17 ? A SER 19  
20 1 Y 1 A HIS -16 ? A HIS 20  
21 1 Y 1 A MET -15 ? A MET 21  
22 1 Y 1 A ALA -14 ? A ALA 22  
23 1 Y 1 A SER -13 ? A SER 23  
24 1 Y 1 A MET -12 ? A MET 24  
25 1 Y 1 A THR -11 ? A THR 25  
26 1 Y 1 A GLY -10 ? A GLY 26  
27 1 Y 1 A GLY -9  ? A GLY 27  
28 1 Y 1 A GLN -8  ? A GLN 28  
29 1 Y 1 A GLN -7  ? A GLN 29  
30 1 Y 1 A MET -6  ? A MET 30  
31 1 Y 1 A GLY -5  ? A GLY 31  
32 1 Y 1 A ARG -4  ? A ARG 32  
33 1 Y 1 A GLY -3  ? A GLY 33  
34 1 Y 1 A SER -2  ? A SER 34  
35 1 Y 1 A GLU -1  ? A GLU 35  
36 1 Y 1 A PHE 0   ? A PHE 36  
37 1 Y 1 A LEU 1   ? A LEU 37  
38 1 Y 1 A ALA 272 ? A ALA 308 
39 1 Y 1 A SER 273 ? A SER 309 
40 1 Y 1 A GLN 274 ? A GLN 310 
41 1 Y 1 A ASP 275 ? A ASP 311 
42 1 Y 1 A GLN 276 ? A GLN 312 
43 1 Y 1 A GLY 277 ? A GLY 313 
44 1 Y 1 A ARG 278 ? A ARG 314 
45 1 Y 1 A ARG 279 ? A ARG 315 
46 1 Y 1 A GLY 280 ? A GLY 316 
47 1 Y 1 A SER 281 ? A SER 317 
48 1 Y 1 A ARG 282 ? A ARG 318 
49 1 Y 1 A ARG 283 ? A ARG 319 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           U22A20542 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'in silico model' 
_pdbx_initial_refinement_model.source_name      AlphaFold 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9JOS 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.006744 
_atom_sites.fract_transf_matrix[1][2]   0.003894 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.007787 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.023787 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
H 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N    . GLY A 1 38  ? -8.662  -17.507 12.691  1.00 57.15  ? 2   GLY A N    1 
ATOM   2    C CA   . GLY A 1 38  ? -7.796  -17.172 11.575  1.00 48.55  ? 2   GLY A CA   1 
ATOM   3    C C    . GLY A 1 38  ? -7.629  -15.678 11.401  1.00 54.84  ? 2   GLY A C    1 
ATOM   4    O O    . GLY A 1 38  ? -7.442  -15.201 10.288  1.00 50.13  ? 2   GLY A O    1 
ATOM   5    H HA2  . GLY A 1 38  ? -6.920  -17.562 11.720  1.00 58.25  ? 2   GLY A HA2  1 
ATOM   6    H HA3  . GLY A 1 38  ? -8.172  -17.534 10.758  1.00 58.25  ? 2   GLY A HA3  1 
ATOM   7    N N    . GLN A 1 39  ? -7.712  -14.939 12.513  1.00 56.22  ? 3   GLN A N    1 
ATOM   8    C CA   . GLN A 1 39  ? -7.495  -13.500 12.493  1.00 53.90  ? 3   GLN A CA   1 
ATOM   9    C C    . GLN A 1 39  ? -6.025  -13.137 12.386  1.00 51.28  ? 3   GLN A C    1 
ATOM   10   O O    . GLN A 1 39  ? -5.699  -12.025 11.961  1.00 48.14  ? 3   GLN A O    1 
ATOM   11   C CB   . GLN A 1 39  ? -8.060  -12.864 13.761  1.00 68.98  ? 3   GLN A CB   1 
ATOM   12   C CG   . GLN A 1 39  ? -9.421  -13.393 14.176  1.00 92.43  ? 3   GLN A CG   1 
ATOM   13   C CD   . GLN A 1 39  ? -9.408  -13.989 15.577  1.00 87.77  ? 3   GLN A CD   1 
ATOM   14   O OE1  . GLN A 1 39  ? -8.690  -14.955 15.856  1.00 67.56  ? 3   GLN A OE1  1 
ATOM   15   N NE2  . GLN A 1 39  ? -10.194 -13.406 16.468  1.00 63.50  ? 3   GLN A NE2  1 
ATOM   16   H H    . GLN A 1 39  ? -7.894  -15.254 13.292  1.00 67.45  ? 3   GLN A H    1 
ATOM   17   H HA   . GLN A 1 39  ? -7.964  -13.132 11.728  1.00 64.67  ? 3   GLN A HA   1 
ATOM   18   H HB2  . GLN A 1 39  ? -7.445  -13.031 14.492  1.00 82.76  ? 3   GLN A HB2  1 
ATOM   19   H HB3  . GLN A 1 39  ? -8.149  -11.909 13.614  1.00 82.76  ? 3   GLN A HB3  1 
ATOM   20   H HG2  . GLN A 1 39  ? -10.062 -12.665 14.164  1.00 110.90 ? 3   GLN A HG2  1 
ATOM   21   H HG3  . GLN A 1 39  ? -9.695  -14.086 13.555  1.00 110.90 ? 3   GLN A HG3  1 
ATOM   22   H HE21 . GLN A 1 39  ? -10.674 -12.729 16.241  1.00 76.19  ? 3   GLN A HE21 1 
ATOM   23   H HE22 . GLN A 1 39  ? -10.224 -13.703 17.275  1.00 76.19  ? 3   GLN A HE22 1 
ATOM   24   N N    . HIS A 1 40  ? -5.134  -14.043 12.768  1.00 50.62  ? 4   HIS A N    1 
ATOM   25   C CA   . HIS A 1 40  ? -3.702  -13.777 12.785  1.00 42.21  ? 4   HIS A CA   1 
ATOM   26   C C    . HIS A 1 40  ? -2.987  -15.053 12.353  1.00 28.89  ? 4   HIS A C    1 
ATOM   27   O O    . HIS A 1 40  ? -3.511  -16.156 12.520  1.00 29.61  ? 4   HIS A O    1 
ATOM   28   C CB   . HIS A 1 40  ? -3.315  -13.271 14.177  1.00 45.12  ? 4   HIS A CB   1 
ATOM   29   C CG   . HIS A 1 40  ? -2.127  -12.364 14.178  1.00 57.68  ? 4   HIS A CG   1 
ATOM   30   N ND1  . HIS A 1 40  ? -1.098  -12.478 13.267  1.00 57.60  ? 4   HIS A ND1  1 
ATOM   31   C CD2  . HIS A 1 40  ? -1.816  -11.309 14.968  1.00 53.34  ? 4   HIS A CD2  1 
ATOM   32   C CE1  . HIS A 1 40  ? -0.190  -11.551 13.514  1.00 53.80  ? 4   HIS A CE1  1 
ATOM   33   N NE2  . HIS A 1 40  ? -0.601  -10.827 14.540  1.00 53.79  ? 4   HIS A NE2  1 
ATOM   34   H H    . HIS A 1 40  ? -5.339  -14.837 13.027  1.00 60.73  ? 4   HIS A H    1 
ATOM   35   H HA   . HIS A 1 40  ? -3.415  -13.099 12.153  1.00 50.64  ? 4   HIS A HA   1 
ATOM   36   H HB2  . HIS A 1 40  ? -4.064  -12.779 14.549  1.00 54.13  ? 4   HIS A HB2  1 
ATOM   37   H HB3  . HIS A 1 40  ? -3.107  -14.033 14.739  1.00 54.13  ? 4   HIS A HB3  1 
ATOM   38   H HD2  . HIS A 1 40  ? -2.328  -10.973 15.668  1.00 64.00  ? 4   HIS A HD2  1 
ATOM   39   H HE1  . HIS A 1 40  ? 0.604   -11.427 13.046  1.00 64.55  ? 4   HIS A HE1  1 
ATOM   40   H HE2  . HIS A 1 40  ? -0.179  -10.162 14.884  1.00 64.54  ? 4   HIS A HE2  1 
ATOM   41   N N    . TYR A 1 41  ? -1.830  -14.898 11.701  1.00 23.28  ? 5   TYR A N    1 
ATOM   42   C CA   . TYR A 1 41  ? -1.113  -16.069 11.203  1.00 20.90  ? 5   TYR A CA   1 
ATOM   43   C C    . TYR A 1 41  ? -0.515  -16.822 12.390  1.00 21.40  ? 5   TYR A C    1 
ATOM   44   O O    . TYR A 1 41  ? 0.026   -16.214 13.310  1.00 21.94  ? 5   TYR A O    1 
ATOM   45   C CB   . TYR A 1 41  ? -0.044  -15.666 10.190  1.00 27.76  ? 5   TYR A CB   1 
ATOM   46   C CG   . TYR A 1 41  ? -0.652  -15.253 8.875   1.00 25.13  ? 5   TYR A CG   1 
ATOM   47   C CD1  . TYR A 1 41  ? -1.164  -16.188 8.027   1.00 19.43  ? 5   TYR A CD1  1 
ATOM   48   C CD2  . TYR A 1 41  ? -0.774  -13.917 8.522   1.00 23.16  ? 5   TYR A CD2  1 
ATOM   49   C CE1  . TYR A 1 41  ? -1.753  -15.856 6.854   1.00 26.65  ? 5   TYR A CE1  1 
ATOM   50   C CE2  . TYR A 1 41  ? -1.366  -13.567 7.334   1.00 23.17  ? 5   TYR A CE2  1 
ATOM   51   C CZ   . TYR A 1 41  ? -1.880  -14.538 6.521   1.00 26.30  ? 5   TYR A CZ   1 
ATOM   52   O OH   . TYR A 1 41  ? -2.491  -14.234 5.335   1.00 27.14  ? 5   TYR A OH   1 
ATOM   53   H H    . TYR A 1 41  ? -1.451  -14.143 11.540  1.00 27.92  ? 5   TYR A H    1 
ATOM   54   H HA   . TYR A 1 41  ? -1.719  -16.662 10.734  1.00 25.07  ? 5   TYR A HA   1 
ATOM   55   H HB2  . TYR A 1 41  ? 0.463   -14.916 10.540  1.00 33.30  ? 5   TYR A HB2  1 
ATOM   56   H HB3  . TYR A 1 41  ? 0.546   -16.419 10.030  1.00 33.30  ? 5   TYR A HB3  1 
ATOM   57   H HD1  . TYR A 1 41  ? -1.108  -17.086 8.262   1.00 23.30  ? 5   TYR A HD1  1 
ATOM   58   H HD2  . TYR A 1 41  ? -0.454  -13.256 9.093   1.00 27.78  ? 5   TYR A HD2  1 
ATOM   59   H HE1  . TYR A 1 41  ? -2.068  -16.518 6.282   1.00 31.97  ? 5   TYR A HE1  1 
ATOM   60   H HE2  . TYR A 1 41  ? -1.418  -12.673 7.084   1.00 27.80  ? 5   TYR A HE2  1 
ATOM   61   H HH   . TYR A 1 41  ? -2.457  -13.406 5.199   1.00 32.56  ? 5   TYR A HH   1 
ATOM   62   N N    . LEU A 1 42  ? -0.665  -18.152 12.396  1.00 21.99  ? 6   LEU A N    1 
ATOM   63   C CA   . LEU A 1 42  ? -0.273  -18.970 13.527  1.00 19.43  ? 6   LEU A CA   1 
ATOM   64   C C    . LEU A 1 42  ? 0.913   -19.830 13.130  1.00 17.03  ? 6   LEU A C    1 
ATOM   65   O O    . LEU A 1 42  ? 0.922   -20.406 12.039  1.00 20.71  ? 6   LEU A O    1 
ATOM   66   C CB   . LEU A 1 42  ? -1.424  -19.870 13.986  1.00 21.52  ? 6   LEU A CB   1 
ATOM   67   C CG   . LEU A 1 42  ? -2.616  -19.091 14.500  1.00 30.94  ? 6   LEU A CG   1 
ATOM   68   C CD1  . LEU A 1 42  ? -3.713  -20.074 14.880  1.00 30.62  ? 6   LEU A CD1  1 
ATOM   69   C CD2  . LEU A 1 42  ? -2.173  -18.254 15.678  1.00 31.11  ? 6   LEU A CD2  1 
ATOM   70   H H    . LEU A 1 42  ? -0.996  -18.601 11.742  1.00 26.37  ? 6   LEU A H    1 
ATOM   71   H HA   . LEU A 1 42  ? -0.019  -18.395 14.265  1.00 23.31  ? 6   LEU A HA   1 
ATOM   72   H HB2  . LEU A 1 42  ? -1.719  -20.410 13.236  1.00 25.82  ? 6   LEU A HB2  1 
ATOM   73   H HB3  . LEU A 1 42  ? -1.108  -20.443 14.702  1.00 25.82  ? 6   LEU A HB3  1 
ATOM   74   H HG   . LEU A 1 42  ? -2.977  -18.491 13.828  1.00 37.12  ? 6   LEU A HG   1 
ATOM   75   H HD11 . LEU A 1 42  ? -4.488  -19.579 15.188  1.00 36.74  ? 6   LEU A HD11 1 
ATOM   76   H HD12 . LEU A 1 42  ? -3.946  -20.603 14.101  1.00 36.74  ? 6   LEU A HD12 1 
ATOM   77   H HD13 . LEU A 1 42  ? -3.387  -20.653 15.587  1.00 36.74  ? 6   LEU A HD13 1 
ATOM   78   H HD21 . LEU A 1 42  ? -2.957  -17.932 16.149  1.00 37.32  ? 6   LEU A HD21 1 
ATOM   79   H HD22 . LEU A 1 42  ? -1.633  -18.801 16.269  1.00 37.32  ? 6   LEU A HD22 1 
ATOM   80   H HD23 . LEU A 1 42  ? -1.652  -17.503 15.353  1.00 37.32  ? 6   LEU A HD23 1 
ATOM   81   N N    . ASN A 1 43  ? 1.944   -19.824 13.967  1.00 18.55  ? 7   ASN A N    1 
ATOM   82   C CA   . ASN A 1 43  ? 3.027   -20.780 13.807  1.00 18.51  ? 7   ASN A CA   1 
ATOM   83   C C    . ASN A 1 43  ? 2.522   -22.162 14.174  1.00 20.89  ? 7   ASN A C    1 
ATOM   84   O O    . ASN A 1 43  ? 1.438   -22.321 14.755  1.00 23.23  ? 7   ASN A O    1 
ATOM   85   C CB   . ASN A 1 43  ? 4.202   -20.402 14.682  1.00 17.52  ? 7   ASN A CB   1 
ATOM   86   C CG   . ASN A 1 43  ? 4.732   -19.014 14.370  1.00 18.92  ? 7   ASN A CG   1 
ATOM   87   O OD1  . ASN A 1 43  ? 4.943   -18.658 13.207  1.00 18.78  ? 7   ASN A OD1  1 
ATOM   88   N ND2  . ASN A 1 43  ? 4.911   -18.226 15.394  1.00 19.18  ? 7   ASN A ND2  1 
ATOM   89   H H    . ASN A 1 43  ? 2.038   -19.282 14.628  1.00 22.25  ? 7   ASN A H    1 
ATOM   90   H HA   . ASN A 1 43  ? 3.334   -20.785 12.887  1.00 22.20  ? 7   ASN A HA   1 
ATOM   91   H HB2  . ASN A 1 43  ? 3.925   -20.417 15.611  1.00 21.02  ? 7   ASN A HB2  1 
ATOM   92   H HB3  . ASN A 1 43  ? 4.921   -21.037 14.540  1.00 21.02  ? 7   ASN A HB3  1 
ATOM   93   H HD21 . ASN A 1 43  ? 5.209   -17.428 15.276  1.00 23.00  ? 7   ASN A HD21 1 
ATOM   94   H HD22 . ASN A 1 43  ? 4.731   -18.505 16.188  1.00 23.00  ? 7   ASN A HD22 1 
ATOM   95   N N    . SER A 1 44  ? 3.305   -23.179 13.830  1.00 19.56  ? 8   SER A N    1 
ATOM   96   C CA   . SER A 1 44  ? 2.803   -24.535 14.020  1.00 18.78  ? 8   SER A CA   1 
ATOM   97   C C    . SER A 1 44  ? 2.665   -24.908 15.485  1.00 26.26  ? 8   SER A C    1 
ATOM   98   O O    . SER A 1 44  ? 2.011   -25.914 15.792  1.00 30.95  ? 8   SER A O    1 
ATOM   99   C CB   . SER A 1 44  ? 3.693   -25.559 13.344  1.00 18.05  ? 8   SER A CB   1 
ATOM   100  O OG   . SER A 1 44  ? 4.996   -25.600 13.897  1.00 20.45  ? 8   SER A OG   1 
ATOM   101  H H    . SER A 1 44  ? 4.096   -23.115 13.499  1.00 23.46  ? 8   SER A H    1 
ATOM   102  H HA   . SER A 1 44  ? 1.929   -24.573 13.599  1.00 22.53  ? 8   SER A HA   1 
ATOM   103  H HB2  . SER A 1 44  ? 3.288   -26.434 13.444  1.00 21.65  ? 8   SER A HB2  1 
ATOM   104  H HB3  . SER A 1 44  ? 3.765   -25.332 12.403  1.00 21.65  ? 8   SER A HB3  1 
ATOM   105  H HG   . SER A 1 44  ? 4.951   -25.634 14.735  1.00 24.53  ? 8   SER A HG   1 
ATOM   106  N N    . ASP A 1 45  ? 3.294   -24.165 16.385  1.00 22.48  ? 9   ASP A N    1 
ATOM   107  C CA   . ASP A 1 45  ? 3.118   -24.391 17.815  1.00 25.65  ? 9   ASP A CA   1 
ATOM   108  C C    . ASP A 1 45  ? 1.924   -23.617 18.349  1.00 31.91  ? 9   ASP A C    1 
ATOM   109  O O    . ASP A 1 45  ? 1.729   -23.547 19.571  1.00 30.95  ? 9   ASP A O    1 
ATOM   110  C CB   . ASP A 1 45  ? 4.391   -24.048 18.582  1.00 27.71  ? 9   ASP A CB   1 
ATOM   111  C CG   . ASP A 1 45  ? 4.709   -22.582 18.579  1.00 28.38  ? 9   ASP A CG   1 
ATOM   112  O OD1  . ASP A 1 45  ? 4.009   -21.837 17.884  1.00 27.09  ? 9   ASP A OD1  1 
ATOM   113  O OD2  . ASP A 1 45  ? 5.658   -22.162 19.265  1.00 30.52  ? 9   ASP A OD2  1 
ATOM   114  H H    . ASP A 1 45  ? 3.831   -23.521 16.192  1.00 26.96  ? 9   ASP A H    1 
ATOM   115  H HA   . ASP A 1 45  ? 2.963   -25.334 17.977  1.00 30.78  ? 9   ASP A HA   1 
ATOM   116  H HB2  . ASP A 1 45  ? 4.287   -24.328 19.505  1.00 33.24  ? 9   ASP A HB2  1 
ATOM   117  H HB3  . ASP A 1 45  ? 5.138   -24.516 18.176  1.00 33.24  ? 9   ASP A HB3  1 
ATOM   118  N N    . GLY A 1 46  ? 1.126   -23.047 17.451  1.00 28.89  ? 10  GLY A N    1 
ATOM   119  C CA   . GLY A 1 46  ? -0.036  -22.283 17.810  1.00 28.61  ? 10  GLY A CA   1 
ATOM   120  C C    . GLY A 1 46  ? 0.233   -20.860 18.207  1.00 24.98  ? 10  GLY A C    1 
ATOM   121  O O    . GLY A 1 46  ? -0.729  -20.113 18.395  1.00 30.28  ? 10  GLY A O    1 
ATOM   122  H H    . GLY A 1 46  ? 1.251   -23.096 16.602  1.00 34.66  ? 10  GLY A H    1 
ATOM   123  H HA2  . GLY A 1 46  ? -0.643  -22.268 17.053  1.00 34.32  ? 10  GLY A HA2  1 
ATOM   124  H HA3  . GLY A 1 46  ? -0.475  -22.719 18.558  1.00 34.32  ? 10  GLY A HA3  1 
ATOM   125  N N    . SER A 1 47  ? 1.503   -20.468 18.363  1.00 25.23  ? 11  SER A N    1 
ATOM   126  C CA   . SER A 1 47  ? 1.837   -19.090 18.681  1.00 24.52  ? 11  SER A CA   1 
ATOM   127  C C    . SER A 1 47  ? 1.602   -18.186 17.483  1.00 24.81  ? 11  SER A C    1 
ATOM   128  O O    . SER A 1 47  ? 1.641   -18.606 16.325  1.00 22.68  ? 11  SER A O    1 
ATOM   129  C CB   . SER A 1 47  ? 3.287   -18.967 19.150  1.00 30.67  ? 11  SER A CB   1 
ATOM   130  O OG   . SER A 1 47  ? 4.224   -19.324 18.139  1.00 25.49  ? 11  SER A OG   1 
ATOM   131  H H    . SER A 1 47  ? 2.185   -20.986 18.288  1.00 30.27  ? 11  SER A H    1 
ATOM   132  H HA   . SER A 1 47  ? 1.267   -18.791 19.407  1.00 29.41  ? 11  SER A HA   1 
ATOM   133  H HB2  . SER A 1 47  ? 3.450   -18.047 19.410  1.00 36.79  ? 11  SER A HB2  1 
ATOM   134  H HB3  . SER A 1 47  ? 3.416   -19.555 19.910  1.00 36.79  ? 11  SER A HB3  1 
ATOM   135  H HG   . SER A 1 47  ? 4.098   -20.118 17.898  1.00 30.58  ? 11  SER A HG   1 
ATOM   136  N N    . ARG A 1 48  ? 1.329   -16.936 17.779  1.00 26.56  ? 12  ARG A N    1 
ATOM   137  C CA   . ARG A 1 48  ? 1.031   -15.959 16.753  1.00 27.16  ? 12  ARG A CA   1 
ATOM   138  C C    . ARG A 1 48  ? 2.321   -15.482 16.101  1.00 25.08  ? 12  ARG A C    1 
ATOM   139  O O    . ARG A 1 48  ? 3.341   -15.283 16.764  1.00 25.09  ? 12  ARG A O    1 
ATOM   140  C CB   . ARG A 1 48  ? 0.254   -14.813 17.403  1.00 35.42  ? 12  ARG A CB   1 
ATOM   141  C CG   . ARG A 1 48  ? -0.047  -13.605 16.569  1.00 46.06  ? 12  ARG A CG   1 
ATOM   142  C CD   . ARG A 1 48  ? -0.908  -12.623 17.405  1.00 52.23  ? 12  ARG A CD   1 
ATOM   143  N NE   . ARG A 1 48  ? -0.814  -12.875 18.843  1.00 59.83  ? 12  ARG A NE   1 
ATOM   144  C CZ   . ARG A 1 48  ? -0.210  -12.084 19.725  1.00 68.73  ? 12  ARG A CZ   1 
ATOM   145  N NH1  . ARG A 1 48  ? 0.349   -10.937 19.365  1.00 58.21  ? 12  ARG A NH1  1 
ATOM   146  N NH2  . ARG A 1 48  ? -0.157  -12.458 21.001  1.00 72.32  ? 12  ARG A NH2  1 
ATOM   147  H H    . ARG A 1 48  ? 1.310   -16.620 18.579  1.00 31.86  ? 12  ARG A H    1 
ATOM   148  H HA   . ARG A 1 48  ? 0.486   -16.330 16.041  1.00 32.58  ? 12  ARG A HA   1 
ATOM   149  H HB2  . ARG A 1 48  ? -0.600  -15.167 17.699  1.00 42.49  ? 12  ARG A HB2  1 
ATOM   150  H HB3  . ARG A 1 48  ? 0.767   -14.504 18.166  1.00 42.49  ? 12  ARG A HB3  1 
ATOM   151  H HG2  . ARG A 1 48  ? 0.778   -13.164 16.315  1.00 55.26  ? 12  ARG A HG2  1 
ATOM   152  H HG3  . ARG A 1 48  ? -0.543  -13.864 15.777  1.00 55.26  ? 12  ARG A HG3  1 
ATOM   153  H HD2  . ARG A 1 48  ? -0.605  -11.716 17.239  1.00 62.67  ? 12  ARG A HD2  1 
ATOM   154  H HD3  . ARG A 1 48  ? -1.838  -12.715 17.143  1.00 62.67  ? 12  ARG A HD3  1 
ATOM   155  H HE   . ARG A 1 48  ? -1.180  -13.594 19.142  1.00 71.78  ? 12  ARG A HE   1 
ATOM   156  H HH11 . ARG A 1 48  ? 0.327   -10.687 18.543  1.00 69.85  ? 12  ARG A HH11 1 
ATOM   157  H HH12 . ARG A 1 48  ? 0.734   -10.443 19.955  1.00 69.85  ? 12  ARG A HH12 1 
ATOM   158  H HH21 . ARG A 1 48  ? -0.511  -13.203 21.246  1.00 86.77  ? 12  ARG A HH21 1 
ATOM   159  H HH22 . ARG A 1 48  ? 0.231   -11.955 21.581  1.00 86.77  ? 12  ARG A HH22 1 
ATOM   160  N N    . PHE A 1 49  ? 2.287   -15.339 14.789  1.00 19.11  ? 13  PHE A N    1 
ATOM   161  C CA   . PHE A 1 49  ? 3.390   -14.716 14.071  1.00 20.69  ? 13  PHE A CA   1 
ATOM   162  C C    . PHE A 1 49  ? 3.035   -13.262 13.798  1.00 18.70  ? 13  PHE A C    1 
ATOM   163  O O    . PHE A 1 49  ? 2.028   -12.977 13.142  1.00 21.64  ? 13  PHE A O    1 
ATOM   164  C CB   . PHE A 1 49  ? 3.670   -15.422 12.760  1.00 17.69  ? 13  PHE A CB   1 
ATOM   165  C CG   . PHE A 1 49  ? 4.894   -14.926 12.079  1.00 17.28  ? 13  PHE A CG   1 
ATOM   166  C CD1  . PHE A 1 49  ? 4.861   -13.750 11.373  1.00 16.05  ? 13  PHE A CD1  1 
ATOM   167  C CD2  . PHE A 1 49  ? 6.073   -15.638 12.137  1.00 22.00  ? 13  PHE A CD2  1 
ATOM   168  C CE1  . PHE A 1 49  ? 5.988   -13.281 10.747  1.00 15.73  ? 13  PHE A CE1  1 
ATOM   169  C CE2  . PHE A 1 49  ? 7.199   -15.179 11.505  1.00 19.64  ? 13  PHE A CE2  1 
ATOM   170  C CZ   . PHE A 1 49  ? 7.159   -14.009 10.807  1.00 18.16  ? 13  PHE A CZ   1 
ATOM   171  H H    . PHE A 1 49  ? 1.636   -15.596 14.289  1.00 22.92  ? 13  PHE A H    1 
ATOM   172  H HA   . PHE A 1 49  ? 4.188   -14.759 14.622  1.00 24.81  ? 13  PHE A HA   1 
ATOM   173  H HB2  . PHE A 1 49  ? 3.787   -16.370 12.932  1.00 21.22  ? 13  PHE A HB2  1 
ATOM   174  H HB3  . PHE A 1 49  ? 2.919   -15.284 12.162  1.00 21.22  ? 13  PHE A HB3  1 
ATOM   175  H HD1  . PHE A 1 49  ? 4.068   -13.266 11.319  1.00 19.25  ? 13  PHE A HD1  1 
ATOM   176  H HD2  . PHE A 1 49  ? 6.104   -16.438 12.610  1.00 26.39  ? 13  PHE A HD2  1 
ATOM   177  H HE1  . PHE A 1 49  ? 5.963   -12.476 10.282  1.00 18.87  ? 13  PHE A HE1  1 
ATOM   178  H HE2  . PHE A 1 49  ? 7.990   -15.666 11.553  1.00 23.56  ? 13  PHE A HE2  1 
ATOM   179  H HZ   . PHE A 1 49  ? 7.921   -13.700 10.372  1.00 21.78  ? 13  PHE A HZ   1 
ATOM   180  N N    . VAL A 1 50  ? 3.858   -12.344 14.281  1.00 19.78  ? 14  VAL A N    1 
ATOM   181  C CA   . VAL A 1 50  ? 3.595   -10.925 14.105  1.00 22.87  ? 14  VAL A CA   1 
ATOM   182  C C    . VAL A 1 50  ? 4.670   -10.387 13.164  1.00 16.97  ? 14  VAL A C    1 
ATOM   183  O O    . VAL A 1 50  ? 5.840   -10.285 13.564  1.00 20.80  ? 14  VAL A O    1 
ATOM   184  C CB   . VAL A 1 50  ? 3.589   -10.156 15.429  1.00 24.19  ? 14  VAL A CB   1 
ATOM   185  C CG1  . VAL A 1 50  ? 3.289   -8.675  15.180  1.00 24.28  ? 14  VAL A CG1  1 
ATOM   186  C CG2  . VAL A 1 50  ? 2.583   -10.756 16.381  1.00 29.31  ? 14  VAL A CG2  1 
ATOM   187  H H    . VAL A 1 50  ? 4.579   -12.521 14.717  1.00 23.73  ? 14  VAL A H    1 
ATOM   188  H HA   . VAL A 1 50  ? 2.721   -10.814 13.697  1.00 27.44  ? 14  VAL A HA   1 
ATOM   189  H HB   . VAL A 1 50  ? 4.465   -10.222 15.840  1.00 29.02  ? 14  VAL A HB   1 
ATOM   190  H HG11 . VAL A 1 50  ? 3.138   -8.236  16.031  1.00 29.12  ? 14  VAL A HG11 1 
ATOM   191  H HG12 . VAL A 1 50  ? 4.047   -8.271  14.729  1.00 29.12  ? 14  VAL A HG12 1 
ATOM   192  H HG13 . VAL A 1 50  ? 2.497   -8.602  14.625  1.00 29.12  ? 14  VAL A HG13 1 
ATOM   193  H HG21 . VAL A 1 50  ? 2.572   -10.235 17.198  1.00 35.16  ? 14  VAL A HG21 1 
ATOM   194  H HG22 . VAL A 1 50  ? 1.707   -10.740 15.966  1.00 35.16  ? 14  VAL A HG22 1 
ATOM   195  H HG23 . VAL A 1 50  ? 2.840   -11.671 16.576  1.00 35.16  ? 14  VAL A HG23 1 
ATOM   196  N N    . PRO A 1 51  ? 4.344   -10.115 11.906  1.00 18.12  ? 15  PRO A N    1 
ATOM   197  C CA   . PRO A 1 51  ? 5.363   -9.686  10.955  1.00 20.98  ? 15  PRO A CA   1 
ATOM   198  C C    . PRO A 1 51  ? 5.793   -8.253  11.197  1.00 18.80  ? 15  PRO A C    1 
ATOM   199  O O    . PRO A 1 51  ? 5.036   -7.429  11.707  1.00 21.35  ? 15  PRO A O    1 
ATOM   200  C CB   . PRO A 1 51  ? 4.649   -9.811  9.607   1.00 19.27  ? 15  PRO A CB   1 
ATOM   201  C CG   . PRO A 1 51  ? 3.211   -9.509  9.930   1.00 24.28  ? 15  PRO A CG   1 
ATOM   202  C CD   . PRO A 1 51  ? 3.002   -10.165 11.300  1.00 19.66  ? 15  PRO A CD   1 
ATOM   203  H HA   . PRO A 1 51  ? 6.135   -10.272 10.989  1.00 25.17  ? 15  PRO A HA   1 
ATOM   204  H HB2  . PRO A 1 51  ? 5.010   -9.168  8.976   1.00 23.12  ? 15  PRO A HB2  1 
ATOM   205  H HB3  . PRO A 1 51  ? 4.749   -10.710 9.257   1.00 23.12  ? 15  PRO A HB3  1 
ATOM   206  H HG2  . PRO A 1 51  ? 3.071   -8.550  9.975   1.00 29.12  ? 15  PRO A HG2  1 
ATOM   207  H HG3  . PRO A 1 51  ? 2.627   -9.899  9.261   1.00 29.12  ? 15  PRO A HG3  1 
ATOM   208  H HD2  . PRO A 1 51  ? 2.364   -9.662  11.831  1.00 23.59  ? 15  PRO A HD2  1 
ATOM   209  H HD3  . PRO A 1 51  ? 2.701   -11.082 11.202  1.00 23.59  ? 15  PRO A HD3  1 
ATOM   210  N N    . LYS A 1 52  ? 7.021   -7.949  10.800  1.00 17.22  ? 16  LYS A N    1 
ATOM   211  C CA   . LYS A 1 52  ? 7.369   -6.541  10.754  1.00 21.19  ? 16  LYS A CA   1 
ATOM   212  C C    . LYS A 1 52  ? 6.638   -5.825  9.619   1.00 20.25  ? 16  LYS A C    1 
ATOM   213  O O    . LYS A 1 52  ? 6.256   -6.411  8.600   1.00 19.99  ? 16  LYS A O    1 
ATOM   214  C CB   . LYS A 1 52  ? 8.883   -6.364  10.611  1.00 21.05  ? 16  LYS A CB   1 
ATOM   215  C CG   . LYS A 1 52  ? 9.732   -7.229  11.539  1.00 28.23  ? 16  LYS A CG   1 
ATOM   216  C CD   . LYS A 1 52  ? 9.869   -6.636  12.897  1.00 30.15  ? 16  LYS A CD   1 
ATOM   217  C CE   . LYS A 1 52  ? 10.847  -7.417  13.760  1.00 34.64  ? 16  LYS A CE   1 
ATOM   218  N NZ   . LYS A 1 52  ? 12.272  -7.289  13.302  1.00 42.07  ? 16  LYS A NZ   1 
ATOM   219  H H    . LYS A 1 52  ? 7.633   -8.507  10.566  1.00 20.65  ? 16  LYS A H    1 
ATOM   220  H HA   . LYS A 1 52  ? 7.096   -6.122  11.585  1.00 25.42  ? 16  LYS A HA   1 
ATOM   221  H HB2  . LYS A 1 52  ? 9.132   -6.586  9.700   1.00 25.25  ? 16  LYS A HB2  1 
ATOM   222  H HB3  . LYS A 1 52  ? 9.102   -5.438  10.798  1.00 25.25  ? 16  LYS A HB3  1 
ATOM   223  H HG2  . LYS A 1 52  ? 9.316   -8.101  11.631  1.00 33.86  ? 16  LYS A HG2  1 
ATOM   224  H HG3  . LYS A 1 52  ? 10.620  -7.325  11.161  1.00 33.86  ? 16  LYS A HG3  1 
ATOM   225  H HD2  . LYS A 1 52  ? 10.195  -5.725  12.817  1.00 36.17  ? 16  LYS A HD2  1 
ATOM   226  H HD3  . LYS A 1 52  ? 9.005   -6.641  13.338  1.00 36.17  ? 16  LYS A HD3  1 
ATOM   227  H HE2  . LYS A 1 52  ? 10.797  -7.086  14.671  1.00 41.56  ? 16  LYS A HE2  1 
ATOM   228  H HE3  . LYS A 1 52  ? 10.609  -8.356  13.735  1.00 41.56  ? 16  LYS A HE3  1 
ATOM   229  H HZ1  . LYS A 1 52  ? 12.809  -7.744  13.847  1.00 50.47  ? 16  LYS A HZ1  1 
ATOM   230  H HZ2  . LYS A 1 52  ? 12.356  -7.613  12.477  1.00 50.47  ? 16  LYS A HZ2  1 
ATOM   231  H HZ3  . LYS A 1 52  ? 12.516  -6.433  13.303  1.00 50.47  ? 16  LYS A HZ3  1 
ATOM   232  N N    . ASP A 1 53  ? 6.493   -4.498  9.780   1.00 19.00  ? 17  ASP A N    1 
ATOM   233  C CA   . ASP A 1 53  ? 5.763   -3.714  8.804   1.00 21.54  ? 17  ASP A CA   1 
ATOM   234  C C    . ASP A 1 53  ? 6.379   -3.787  7.414   1.00 20.73  ? 17  ASP A C    1 
ATOM   235  O O    . ASP A 1 53  ? 5.692   -3.528  6.420   1.00 23.36  ? 17  ASP A O    1 
ATOM   236  C CB   . ASP A 1 53  ? 5.725   -2.242  9.252   1.00 29.99  ? 17  ASP A CB   1 
ATOM   237  C CG   . ASP A 1 53  ? 4.676   -1.962  10.313  1.00 36.49  ? 17  ASP A CG   1 
ATOM   238  O OD1  . ASP A 1 53  ? 4.132   -2.918  10.907  1.00 43.36  ? 17  ASP A OD1  1 
ATOM   239  H H    . ASP A 1 53  ? 6.807   -4.045  10.439  1.00 22.79  ? 17  ASP A H    1 
ATOM   240  H HA   . ASP A 1 53  ? 4.860   -4.066  8.753   1.00 25.84  ? 17  ASP A HA   1 
ATOM   241  H HB2  . ASP A 1 53  ? 6.590   -2.004  9.620   1.00 35.97  ? 17  ASP A HB2  1 
ATOM   242  H HB3  . ASP A 1 53  ? 5.526   -1.685  8.483   1.00 35.97  ? 17  ASP A HB3  1 
ATOM   243  N N    . PHE A 1 54  ? 7.687   -4.055  7.317   1.00 19.37  ? 18  PHE A N    1 
ATOM   244  C CA   . PHE A 1 54  ? 8.386   -4.026  6.041   1.00 17.55  ? 18  PHE A CA   1 
ATOM   245  C C    . PHE A 1 54  ? 8.533   -5.397  5.403   1.00 18.30  ? 18  PHE A C    1 
ATOM   246  O O    . PHE A 1 54  ? 9.167   -5.507  4.348   1.00 18.52  ? 18  PHE A O    1 
ATOM   247  C CB   . PHE A 1 54  ? 9.776   -3.390  6.215   1.00 18.58  ? 18  PHE A CB   1 
ATOM   248  C CG   . PHE A 1 54  ? 10.653  -4.113  7.150   1.00 19.17  ? 18  PHE A CG   1 
ATOM   249  C CD1  . PHE A 1 54  ? 11.484  -5.124  6.697   1.00 19.15  ? 18  PHE A CD1  1 
ATOM   250  C CD2  . PHE A 1 54  ? 10.680  -3.784  8.508   1.00 21.75  ? 18  PHE A CD2  1 
ATOM   251  C CE1  . PHE A 1 54  ? 12.320  -5.778  7.552   1.00 17.19  ? 18  PHE A CE1  1 
ATOM   252  C CE2  . PHE A 1 54  ? 11.501  -4.454  9.384   1.00 24.15  ? 18  PHE A CE2  1 
ATOM   253  C CZ   . PHE A 1 54  ? 12.324  -5.476  8.916   1.00 20.74  ? 18  PHE A CZ   1 
ATOM   254  H H    . PHE A 1 54  ? 8.188   -4.258  7.986   1.00 23.24  ? 18  PHE A H    1 
ATOM   255  H HA   . PHE A 1 54  ? 7.869   -3.475  5.433   1.00 21.05  ? 18  PHE A HA   1 
ATOM   256  H HB2  . PHE A 1 54  ? 10.219  -3.369  5.352   1.00 22.28  ? 18  PHE A HB2  1 
ATOM   257  H HB3  . PHE A 1 54  ? 9.665   -2.487  6.552   1.00 22.28  ? 18  PHE A HB3  1 
ATOM   258  H HD1  . PHE A 1 54  ? 11.471  -5.360  5.797   1.00 22.97  ? 18  PHE A HD1  1 
ATOM   259  H HD2  . PHE A 1 54  ? 10.133  -3.102  8.825   1.00 26.09  ? 18  PHE A HD2  1 
ATOM   260  H HE1  . PHE A 1 54  ? 12.894  -6.432  7.224   1.00 20.62  ? 18  PHE A HE1  1 
ATOM   261  H HE2  . PHE A 1 54  ? 11.508  -4.225  10.285  1.00 28.97  ? 18  PHE A HE2  1 
ATOM   262  H HZ   . PHE A 1 54  ? 12.868  -5.951  9.503   1.00 24.88  ? 18  PHE A HZ   1 
ATOM   263  N N    . TYR A 1 55  ? 7.911   -6.429  5.979   1.00 17.30  ? 19  TYR A N    1 
ATOM   264  C CA   . TYR A 1 55  ? 7.967   -7.745  5.388   1.00 15.69  ? 19  TYR A CA   1 
ATOM   265  C C    . TYR A 1 55  ? 7.137   -7.799  4.115   1.00 20.68  ? 19  TYR A C    1 
ATOM   266  O O    . TYR A 1 55  ? 6.195   -7.021  3.939   1.00 17.12  ? 19  TYR A O    1 
ATOM   267  C CB   . TYR A 1 55  ? 7.450   -8.782  6.367   1.00 19.10  ? 19  TYR A CB   1 
ATOM   268  C CG   . TYR A 1 55  ? 8.428   -9.221  7.428   1.00 20.06  ? 19  TYR A CG   1 
ATOM   269  C CD1  . TYR A 1 55  ? 9.649   -8.559  7.628   1.00 21.16  ? 19  TYR A CD1  1 
ATOM   270  C CD2  . TYR A 1 55  ? 8.116   -10.285 8.253   1.00 17.91  ? 19  TYR A CD2  1 
ATOM   271  C CE1  . TYR A 1 55  ? 10.530  -8.979  8.613   1.00 23.53  ? 19  TYR A CE1  1 
ATOM   272  C CE2  . TYR A 1 55  ? 8.971   -10.714 9.218   1.00 20.27  ? 19  TYR A CE2  1 
ATOM   273  C CZ   . TYR A 1 55  ? 10.191  -10.068 9.395   1.00 17.06  ? 19  TYR A CZ   1 
ATOM   274  O OH   . TYR A 1 55  ? 11.018  -10.487 10.398  1.00 19.04  ? 19  TYR A OH   1 
ATOM   275  H H    . TYR A 1 55  ? 7.456   -6.383  6.707   1.00 20.75  ? 19  TYR A H    1 
ATOM   276  H HA   . TYR A 1 55  ? 8.887   -7.954  5.165   1.00 18.81  ? 19  TYR A HA   1 
ATOM   277  H HB2  . TYR A 1 55  ? 6.677   -8.412  6.822   1.00 22.91  ? 19  TYR A HB2  1 
ATOM   278  H HB3  . TYR A 1 55  ? 7.194   -9.572  5.866   1.00 22.91  ? 19  TYR A HB3  1 
ATOM   279  H HD1  . TYR A 1 55  ? 9.870   -7.831  7.093   1.00 25.38  ? 19  TYR A HD1  1 
ATOM   280  H HD2  . TYR A 1 55  ? 7.301   -10.718 8.146   1.00 21.49  ? 19  TYR A HD2  1 
ATOM   281  H HE1  . TYR A 1 55  ? 11.337  -8.535  8.746   1.00 28.22  ? 19  TYR A HE1  1 
ATOM   282  H HE2  . TYR A 1 55  ? 8.742   -11.437 9.757   1.00 24.32  ? 19  TYR A HE2  1 
ATOM   283  H HH   . TYR A 1 55  ? 10.610  -11.022 10.901  1.00 22.84  ? 19  TYR A HH   1 
ATOM   284  N N    . PRO A 1 56  ? 7.435   -8.739  3.229   1.00 15.67  ? 20  PRO A N    1 
ATOM   285  C CA   . PRO A 1 56  ? 6.593   -8.935  2.050   1.00 17.70  ? 20  PRO A CA   1 
ATOM   286  C C    . PRO A 1 56  ? 5.213   -9.417  2.471   1.00 18.53  ? 20  PRO A C    1 
ATOM   287  O O    . PRO A 1 56  ? 4.966   -9.769  3.626   1.00 18.26  ? 20  PRO A O    1 
ATOM   288  C CB   . PRO A 1 56  ? 7.356   -10.009 1.244   1.00 22.19  ? 20  PRO A CB   1 
ATOM   289  C CG   . PRO A 1 56  ? 8.148   -10.711 2.248   1.00 20.33  ? 20  PRO A CG   1 
ATOM   290  C CD   . PRO A 1 56  ? 8.534   -9.721  3.292   1.00 16.49  ? 20  PRO A CD   1 
ATOM   291  H HA   . PRO A 1 56  ? 6.520   -8.128  1.517   1.00 21.23  ? 20  PRO A HA   1 
ATOM   292  H HB2  . PRO A 1 56  ? 6.728   -10.609 0.811   1.00 26.62  ? 20  PRO A HB2  1 
ATOM   293  H HB3  . PRO A 1 56  ? 7.924   -9.588  0.581   1.00 26.62  ? 20  PRO A HB3  1 
ATOM   294  H HG2  . PRO A 1 56  ? 7.614   -11.421 2.638   1.00 24.39  ? 20  PRO A HG2  1 
ATOM   295  H HG3  . PRO A 1 56  ? 8.939   -11.083 1.828   1.00 24.39  ? 20  PRO A HG3  1 
ATOM   296  H HD2  . PRO A 1 56  ? 8.578   -10.137 4.167   1.00 19.78  ? 20  PRO A HD2  1 
ATOM   297  H HD3  . PRO A 1 56  ? 9.384   -9.305  3.079   1.00 19.78  ? 20  PRO A HD3  1 
ATOM   298  N N    . LYS A 1 57  ? 4.310   -9.406  1.504   1.00 16.01  ? 21  LYS A N    1 
ATOM   299  C CA   . LYS A 1 57  ? 2.981   -9.965  1.711   1.00 15.26  ? 21  LYS A CA   1 
ATOM   300  C C    . LYS A 1 57  ? 3.106   -11.463 1.995   1.00 16.21  ? 21  LYS A C    1 
ATOM   301  O O    . LYS A 1 57  ? 4.071   -12.119 1.596   1.00 19.08  ? 21  LYS A O    1 
ATOM   302  C CB   . LYS A 1 57  ? 2.108   -9.701  0.494   1.00 23.02  ? 21  LYS A CB   1 
ATOM   303  C CG   . LYS A 1 57  ? 1.622   -8.248  0.384   1.00 22.36  ? 21  LYS A CG   1 
ATOM   304  H H    . LYS A 1 57  ? 4.439   -9.082  0.718   1.00 19.20  ? 21  LYS A H    1 
ATOM   305  H HA   . LYS A 1 57  ? 2.542   -9.547  2.468   1.00 18.31  ? 21  LYS A HA   1 
ATOM   306  H HB2  . LYS A 1 57  ? 2.618   -9.905  -0.305  1.00 27.61  ? 21  LYS A HB2  1 
ATOM   307  H HB3  . LYS A 1 57  ? 1.325   -10.272 0.543   1.00 27.61  ? 21  LYS A HB3  1 
ATOM   308  N N    . PHE A 1 58  ? 2.141   -11.982 2.738   1.00 17.64  ? 22  PHE A N    1 
ATOM   309  C CA   . PHE A 1 58  ? 2.054   -13.411 2.988   1.00 16.37  ? 22  PHE A CA   1 
ATOM   310  C C    . PHE A 1 58  ? 0.598   -13.811 3.006   1.00 18.53  ? 22  PHE A C    1 
ATOM   311  O O    . PHE A 1 58  ? -0.248  -13.087 3.533   1.00 20.39  ? 22  PHE A O    1 
ATOM   312  C CB   . PHE A 1 58  ? 2.669   -13.841 4.316   1.00 16.53  ? 22  PHE A CB   1 
ATOM   313  C CG   . PHE A 1 58  ? 2.595   -15.325 4.538   1.00 16.92  ? 22  PHE A CG   1 
ATOM   314  C CD1  . PHE A 1 58  ? 3.504   -16.151 3.946   1.00 14.46  ? 22  PHE A CD1  1 
ATOM   315  C CD2  . PHE A 1 58  ? 1.603   -15.887 5.312   1.00 19.30  ? 22  PHE A CD2  1 
ATOM   316  C CE1  . PHE A 1 58  ? 3.441   -17.488 4.113   1.00 16.29  ? 22  PHE A CE1  1 
ATOM   317  C CE2  . PHE A 1 58  ? 1.571   -17.243 5.481   1.00 14.75  ? 22  PHE A CE2  1 
ATOM   318  C CZ   . PHE A 1 58  ? 2.478   -18.021 4.873   1.00 15.90  ? 22  PHE A CZ   1 
ATOM   319  H H    . PHE A 1 58  ? 1.518   -11.522 3.112   1.00 21.15  ? 22  PHE A H    1 
ATOM   320  H HA   . PHE A 1 58  ? 2.533   -13.864 2.276   1.00 19.64  ? 22  PHE A HA   1 
ATOM   321  H HB2  . PHE A 1 58  ? 3.604   -13.582 4.330   1.00 19.82  ? 22  PHE A HB2  1 
ATOM   322  H HB3  . PHE A 1 58  ? 2.193   -13.405 5.040   1.00 19.82  ? 22  PHE A HB3  1 
ATOM   323  H HD1  . PHE A 1 58  ? 4.178   -15.787 3.419   1.00 17.34  ? 22  PHE A HD1  1 
ATOM   324  H HD2  . PHE A 1 58  ? 0.961   -15.348 5.715   1.00 23.15  ? 22  PHE A HD2  1 
ATOM   325  H HE1  . PHE A 1 58  ? 4.066   -18.038 3.700   1.00 19.54  ? 22  PHE A HE1  1 
ATOM   326  H HE2  . PHE A 1 58  ? 0.919   -17.628 6.021   1.00 17.69  ? 22  PHE A HE2  1 
ATOM   327  H HZ   . PHE A 1 58  ? 2.437   -18.943 4.980   1.00 19.07  ? 22  PHE A HZ   1 
ATOM   328  N N    . SER A 1 59  ? 0.348   -15.004 2.502   1.00 19.25  ? 23  SER A N    1 
ATOM   329  C CA   . SER A 1 59  ? -0.968  -15.600 2.557   1.00 21.63  ? 23  SER A CA   1 
ATOM   330  C C    . SER A 1 59  ? -0.771  -17.092 2.373   1.00 17.57  ? 23  SER A C    1 
ATOM   331  O O    . SER A 1 59  ? 0.211   -17.536 1.757   1.00 19.30  ? 23  SER A O    1 
ATOM   332  C CB   . SER A 1 59  ? -1.843  -14.972 1.474   1.00 27.19  ? 23  SER A CB   1 
ATOM   333  O OG   . SER A 1 59  ? -2.695  -15.871 0.857   1.00 22.29  ? 23  SER A OG   1 
ATOM   334  H H    . SER A 1 59  ? 0.936   -15.498 2.116   1.00 23.09  ? 23  SER A H    1 
ATOM   335  H HA   . SER A 1 59  ? -1.418  -15.471 3.406   1.00 25.94  ? 23  SER A HA   1 
ATOM   336  H HB2  . SER A 1 59  ? -2.380  -14.276 1.883   1.00 32.62  ? 23  SER A HB2  1 
ATOM   337  H HB3  . SER A 1 59  ? -1.262  -14.590 0.797   1.00 32.62  ? 23  SER A HB3  1 
ATOM   338  H HG   . SER A 1 59  ? -3.199  -15.466 0.320   1.00 26.73  ? 23  SER A HG   1 
ATOM   339  N N    . TRP A 1 60  ? -1.690  -17.852 2.922   1.00 16.91  ? 24  TRP A N    1 
ATOM   340  C CA   . TRP A 1 60  ? -1.733  -19.285 2.661   1.00 16.31  ? 24  TRP A CA   1 
ATOM   341  C C    . TRP A 1 60  ? -2.629  -19.644 1.467   1.00 22.03  ? 24  TRP A C    1 
ATOM   342  O O    . TRP A 1 60  ? -2.849  -20.826 1.208   1.00 18.93  ? 24  TRP A O    1 
ATOM   343  C CB   . TRP A 1 60  ? -2.259  -20.001 3.889   1.00 20.18  ? 24  TRP A CB   1 
ATOM   344  C CG   . TRP A 1 60  ? -1.425  -20.009 5.120   1.00 15.83  ? 24  TRP A CG   1 
ATOM   345  C CD1  . TRP A 1 60  ? -1.715  -19.459 6.315   1.00 16.78  ? 24  TRP A CD1  1 
ATOM   346  C CD2  . TRP A 1 60  ? -0.212  -20.713 5.289   1.00 14.10  ? 24  TRP A CD2  1 
ATOM   347  N NE1  . TRP A 1 60  ? -0.756  -19.756 7.224   1.00 19.65  ? 24  TRP A NE1  1 
ATOM   348  C CE2  . TRP A 1 60  ? 0.197   -20.514 6.621   1.00 15.90  ? 24  TRP A CE2  1 
ATOM   349  C CE3  . TRP A 1 60  ? 0.575   -21.472 4.446   1.00 16.10  ? 24  TRP A CE3  1 
ATOM   350  C CZ2  . TRP A 1 60  ? 1.357   -21.059 7.130   1.00 21.22  ? 24  TRP A CZ2  1 
ATOM   351  C CZ3  . TRP A 1 60  ? 1.758   -22.000 4.942   1.00 20.30  ? 24  TRP A CZ3  1 
ATOM   352  C CH2  . TRP A 1 60  ? 2.117   -21.805 6.283   1.00 19.70  ? 24  TRP A CH2  1 
ATOM   353  H H    . TRP A 1 60  ? -2.305  -17.568 3.451   1.00 20.28  ? 24  TRP A H    1 
ATOM   354  H HA   . TRP A 1 60  ? -0.833  -19.596 2.473   1.00 19.56  ? 24  TRP A HA   1 
ATOM   355  H HB2  . TRP A 1 60  ? -3.102  -19.587 4.130   1.00 24.20  ? 24  TRP A HB2  1 
ATOM   356  H HB3  . TRP A 1 60  ? -2.403  -20.930 3.647   1.00 24.20  ? 24  TRP A HB3  1 
ATOM   357  H HD1  . TRP A 1 60  ? -2.471  -18.946 6.492   1.00 20.13  ? 24  TRP A HD1  1 
ATOM   358  H HE1  . TRP A 1 60  ? -0.751  -19.506 8.046   1.00 23.57  ? 24  TRP A HE1  1 
ATOM   359  H HE3  . TRP A 1 60  ? 0.318   -21.625 3.565   1.00 19.31  ? 24  TRP A HE3  1 
ATOM   360  H HZ2  . TRP A 1 60  ? 1.609   -20.921 8.014   1.00 25.45  ? 24  TRP A HZ2  1 
ATOM   361  H HZ3  . TRP A 1 60  ? 2.318   -22.487 4.381   1.00 24.35  ? 24  TRP A HZ3  1 
ATOM   362  H HH2  . TRP A 1 60  ? 2.897   -22.198 6.604   1.00 23.63  ? 24  TRP A HH2  1 
ATOM   363  N N    . ASP A 1 61  ? -3.179  -18.656 0.757   1.00 21.18  ? 25  ASP A N    1 
ATOM   364  C CA   . ASP A 1 61  ? -4.165  -18.959 -0.285  1.00 24.15  ? 25  ASP A CA   1 
ATOM   365  C C    . ASP A 1 61  ? -3.664  -20.012 -1.257  1.00 20.06  ? 25  ASP A C    1 
ATOM   366  O O    . ASP A 1 61  ? -4.382  -20.959 -1.606  1.00 18.63  ? 25  ASP A O    1 
ATOM   367  C CB   . ASP A 1 61  ? -4.531  -17.697 -1.057  1.00 23.88  ? 25  ASP A CB   1 
ATOM   368  C CG   . ASP A 1 61  ? -5.369  -16.750 -0.246  1.00 25.38  ? 25  ASP A CG   1 
ATOM   369  O OD1  . ASP A 1 61  ? -5.873  -17.136 0.842   1.00 24.31  ? 25  ASP A OD1  1 
ATOM   370  O OD2  . ASP A 1 61  ? -5.487  -15.586 -0.693  1.00 27.92  ? 25  ASP A OD2  1 
ATOM   371  H H    . ASP A 1 61  ? -3.004  -17.820 0.855   1.00 25.40  ? 25  ASP A H    1 
ATOM   372  H HA   . ASP A 1 61  ? -4.958  -19.300 0.159   1.00 28.96  ? 25  ASP A HA   1 
ATOM   373  H HB2  . ASP A 1 61  ? -3.717  -17.235 -1.313  1.00 28.65  ? 25  ASP A HB2  1 
ATOM   374  H HB3  . ASP A 1 61  ? -5.035  -17.944 -1.848  1.00 28.65  ? 25  ASP A HB3  1 
ATOM   375  N N    . THR A 1 62  ? -2.441  -19.854 -1.727  1.00 20.46  ? 26  THR A N    1 
ATOM   376  C CA   . THR A 1 62  ? -1.731  -20.843 -2.510  1.00 21.38  ? 26  THR A CA   1 
ATOM   377  C C    . THR A 1 62  ? -0.335  -20.934 -1.919  1.00 20.66  ? 26  THR A C    1 
ATOM   378  O O    . THR A 1 62  ? -0.017  -20.232 -0.954  1.00 17.86  ? 26  THR A O    1 
ATOM   379  C CB   . THR A 1 62  ? -1.690  -20.452 -3.992  1.00 25.56  ? 26  THR A CB   1 
ATOM   380  O OG1  . THR A 1 62  ? -1.051  -19.163 -4.110  1.00 23.78  ? 26  THR A OG1  1 
ATOM   381  C CG2  . THR A 1 62  ? -3.114  -20.380 -4.532  1.00 25.00  ? 26  THR A CG2  1 
ATOM   382  H H    . THR A 1 62  ? -1.976  -19.142 -1.596  1.00 24.54  ? 26  THR A H    1 
ATOM   383  H HA   . THR A 1 62  ? -2.166  -21.709 -2.459  1.00 25.64  ? 26  THR A HA   1 
ATOM   384  H HB   . THR A 1 62  ? -1.195  -21.103 -4.513  1.00 30.66  ? 26  THR A HB   1 
ATOM   385  H HG1  . THR A 1 62  ? -1.217  -18.828 -4.862  1.00 28.53  ? 26  THR A HG1  1 
ATOM   386  H HG21 . THR A 1 62  ? -3.098  -20.210 -5.487  1.00 29.99  ? 26  THR A HG21 1 
ATOM   387  H HG22 . THR A 1 62  ? -3.573  -21.219 -4.370  1.00 29.99  ? 26  THR A HG22 1 
ATOM   388  H HG23 . THR A 1 62  ? -3.600  -19.665 -4.093  1.00 29.99  ? 26  THR A HG23 1 
ATOM   389  N N    . THR A 1 63  ? 0.492   -21.816 -2.459  1.00 20.13  ? 27  THR A N    1 
ATOM   390  C CA   . THR A 1 63  ? 1.794   -22.011 -1.861  1.00 18.74  ? 27  THR A CA   1 
ATOM   391  C C    . THR A 1 63  ? 2.542   -20.683 -1.836  1.00 21.62  ? 27  THR A C    1 
ATOM   392  O O    . THR A 1 63  ? 2.679   -20.054 -2.874  1.00 16.08  ? 27  THR A O    1 
ATOM   393  C CB   . THR A 1 63  ? 2.592   -23.029 -2.640  1.00 20.57  ? 27  THR A CB   1 
ATOM   394  O OG1  . THR A 1 63  ? 1.967   -24.313 -2.497  1.00 22.01  ? 27  THR A OG1  1 
ATOM   395  C CG2  . THR A 1 63  ? 4.000   -23.114 -2.130  1.00 19.47  ? 27  THR A CG2  1 
ATOM   396  H H    . THR A 1 63  ? 0.325   -22.299 -3.151  1.00 24.15  ? 27  THR A H    1 
ATOM   397  H HA   . THR A 1 63  ? 1.687   -22.339 -0.954  1.00 22.47  ? 27  THR A HA   1 
ATOM   398  H HB   . THR A 1 63  ? 2.626   -22.769 -3.574  1.00 24.67  ? 27  THR A HB   1 
ATOM   399  H HG1  . THR A 1 63  ? 1.299   -24.366 -3.003  1.00 26.40  ? 27  THR A HG1  1 
ATOM   400  H HG21 . THR A 1 63  ? 4.460   -23.857 -2.551  1.00 23.35  ? 27  THR A HG21 1 
ATOM   401  H HG22 . THR A 1 63  ? 4.476   -22.293 -2.332  1.00 23.35  ? 27  THR A HG22 1 
ATOM   402  H HG23 . THR A 1 63  ? 3.997   -23.248 -1.169  1.00 23.35  ? 27  THR A HG23 1 
ATOM   403  N N    . PRO A 1 64  ? 3.037   -20.239 -0.691  1.00 16.81  ? 28  PRO A N    1 
ATOM   404  C CA   . PRO A 1 64  ? 3.748   -18.949 -0.661  1.00 16.27  ? 28  PRO A CA   1 
ATOM   405  C C    . PRO A 1 64  ? 5.077   -19.102 -1.366  1.00 17.93  ? 28  PRO A C    1 
ATOM   406  O O    . PRO A 1 64  ? 5.825   -20.040 -1.099  1.00 15.29  ? 28  PRO A O    1 
ATOM   407  C CB   . PRO A 1 64  ? 3.920   -18.666 0.838   1.00 16.82  ? 28  PRO A CB   1 
ATOM   408  C CG   . PRO A 1 64  ? 2.989   -19.630 1.543   1.00 24.41  ? 28  PRO A CG   1 
ATOM   409  C CD   . PRO A 1 64  ? 2.900   -20.816 0.659   1.00 19.07  ? 28  PRO A CD   1 
ATOM   410  H HA   . PRO A 1 64  ? 3.227   -18.234 -1.058  1.00 19.51  ? 28  PRO A HA   1 
ATOM   411  H HB2  . PRO A 1 64  ? 4.841   -18.823 1.098   1.00 20.17  ? 28  PRO A HB2  1 
ATOM   412  H HB3  . PRO A 1 64  ? 3.673   -17.747 1.028   1.00 20.17  ? 28  PRO A HB3  1 
ATOM   413  H HG2  . PRO A 1 64  ? 3.360   -19.872 2.407   1.00 29.28  ? 28  PRO A HG2  1 
ATOM   414  H HG3  . PRO A 1 64  ? 2.118   -19.220 1.659   1.00 29.28  ? 28  PRO A HG3  1 
ATOM   415  H HD2  . PRO A 1 64  ? 3.619   -21.440 0.843   1.00 22.87  ? 28  PRO A HD2  1 
ATOM   416  H HD3  . PRO A 1 64  ? 2.043   -21.259 0.760   1.00 22.87  ? 28  PRO A HD3  1 
ATOM   417  N N    . MET A 1 65  ? 5.361   -18.193 -2.291  1.00 15.99  ? 29  MET A N    1 
ATOM   418  C CA   . MET A 1 65  ? 6.445   -18.390 -3.227  1.00 15.88  ? 29  MET A CA   1 
ATOM   419  C C    . MET A 1 65  ? 7.458   -17.281 -3.109  1.00 15.44  ? 29  MET A C    1 
ATOM   420  O O    . MET A 1 65  ? 7.116   -16.118 -2.855  1.00 20.08  ? 29  MET A O    1 
ATOM   421  C CB   . MET A 1 65  ? 5.972   -18.424 -4.695  1.00 16.40  ? 29  MET A CB   1 
ATOM   422  C CG   . MET A 1 65  ? 5.190   -19.693 -5.088  1.00 17.67  ? 29  MET A CG   1 
ATOM   423  S SD   . MET A 1 65  ? 6.027   -21.225 -4.822  1.00 19.55  ? 29  MET A SD   1 
ATOM   424  C CE   . MET A 1 65  ? 7.499   -21.050 -5.866  1.00 22.16  ? 29  MET A CE   1 
ATOM   425  H H    . MET A 1 65  ? 4.934   -17.453 -2.393  1.00 19.18  ? 29  MET A H    1 
ATOM   426  H HA   . MET A 1 65  ? 6.848   -19.245 -3.008  1.00 19.05  ? 29  MET A HA   1 
ATOM   427  H HB2  . MET A 1 65  ? 5.391   -17.662 -4.850  1.00 19.67  ? 29  MET A HB2  1 
ATOM   428  H HB3  . MET A 1 65  ? 6.751   -18.370 -5.271  1.00 19.67  ? 29  MET A HB3  1 
ATOM   429  H HG2  . MET A 1 65  ? 4.372   -19.719 -4.568  1.00 21.20  ? 29  MET A HG2  1 
ATOM   430  H HG3  . MET A 1 65  ? 4.980   -19.641 -6.033  1.00 21.20  ? 29  MET A HG3  1 
ATOM   431  H HE1  . MET A 1 65  ? 8.043   -21.848 -5.781  1.00 26.58  ? 29  MET A HE1  1 
ATOM   432  H HE2  . MET A 1 65  ? 7.221   -20.936 -6.788  1.00 26.58  ? 29  MET A HE2  1 
ATOM   433  H HE3  . MET A 1 65  ? 8.003   -20.274 -5.574  1.00 26.58  ? 29  MET A HE3  1 
ATOM   434  N N    . TYR A 1 66  ? 8.698   -17.669 -3.308  1.00 16.39  ? 30  TYR A N    1 
ATOM   435  C CA   . TYR A 1 66  ? 9.835   -16.777 -3.501  1.00 18.03  ? 30  TYR A CA   1 
ATOM   436  C C    . TYR A 1 66  ? 10.499  -17.148 -4.817  1.00 19.64  ? 30  TYR A C    1 
ATOM   437  O O    . TYR A 1 66  ? 10.632  -18.328 -5.139  1.00 18.72  ? 30  TYR A O    1 
ATOM   438  C CB   . TYR A 1 66  ? 10.799  -16.939 -2.319  1.00 17.62  ? 30  TYR A CB   1 
ATOM   439  C CG   . TYR A 1 66  ? 12.158  -16.261 -2.374  1.00 17.93  ? 30  TYR A CG   1 
ATOM   440  C CD1  . TYR A 1 66  ? 12.324  -14.948 -1.975  1.00 15.82  ? 30  TYR A CD1  1 
ATOM   441  C CD2  . TYR A 1 66  ? 13.283  -16.967 -2.750  1.00 17.11  ? 30  TYR A CD2  1 
ATOM   442  C CE1  . TYR A 1 66  ? 13.570  -14.337 -2.011  1.00 13.59  ? 30  TYR A CE1  1 
ATOM   443  C CE2  . TYR A 1 66  ? 14.524  -16.380 -2.766  1.00 14.53  ? 30  TYR A CE2  1 
ATOM   444  C CZ   . TYR A 1 66  ? 14.673  -15.070 -2.390  1.00 15.45  ? 30  TYR A CZ   1 
ATOM   445  O OH   . TYR A 1 66  ? 15.939  -14.465 -2.361  1.00 16.10  ? 30  TYR A OH   1 
ATOM   446  H H    . TYR A 1 66  ? 8.928   -18.497 -3.339  1.00 19.65  ? 30  TYR A H    1 
ATOM   447  H HA   . TYR A 1 66  ? 9.576   -15.844 -3.554  1.00 21.62  ? 30  TYR A HA   1 
ATOM   448  H HB2  . TYR A 1 66  ? 10.353  -16.592 -1.530  1.00 21.14  ? 30  TYR A HB2  1 
ATOM   449  H HB3  . TYR A 1 66  ? 10.971  -17.888 -2.212  1.00 21.14  ? 30  TYR A HB3  1 
ATOM   450  H HD1  . TYR A 1 66  ? 11.587  -14.465 -1.677  1.00 18.97  ? 30  TYR A HD1  1 
ATOM   451  H HD2  . TYR A 1 66  ? 13.198  -17.859 -2.999  1.00 20.52  ? 30  TYR A HD2  1 
ATOM   452  H HE1  . TYR A 1 66  ? 13.659  -13.440 -1.782  1.00 16.30  ? 30  TYR A HE1  1 
ATOM   453  H HE2  . TYR A 1 66  ? 15.267  -16.872 -3.032  1.00 17.42  ? 30  TYR A HE2  1 
ATOM   454  H HH   . TYR A 1 66  ? 16.524  -15.012 -2.613  1.00 19.31  ? 30  TYR A HH   1 
ATOM   455  N N    . TYR A 1 67  ? 10.970  -16.156 -5.555  1.00 15.73  ? 31  TYR A N    1 
ATOM   456  C CA   . TYR A 1 67  ? 11.623  -16.412 -6.828  1.00 15.65  ? 31  TYR A CA   1 
ATOM   457  C C    . TYR A 1 67  ? 13.004  -15.784 -6.780  1.00 18.23  ? 31  TYR A C    1 
ATOM   458  O O    . TYR A 1 67  ? 13.176  -14.751 -6.162  1.00 17.33  ? 31  TYR A O    1 
ATOM   459  C CB   . TYR A 1 67  ? 10.864  -15.816 -7.991  1.00 15.15  ? 31  TYR A CB   1 
ATOM   460  C CG   . TYR A 1 67  ? 9.712   -16.662 -8.418  1.00 19.71  ? 31  TYR A CG   1 
ATOM   461  C CD1  . TYR A 1 67  ? 8.646   -16.873 -7.575  1.00 17.90  ? 31  TYR A CD1  1 
ATOM   462  C CD2  . TYR A 1 67  ? 9.690   -17.239 -9.686  1.00 25.87  ? 31  TYR A CD2  1 
ATOM   463  C CE1  . TYR A 1 67  ? 7.577   -17.667 -7.973  1.00 19.44  ? 31  TYR A CE1  1 
ATOM   464  C CE2  . TYR A 1 67  ? 8.625   -18.008 -10.101 1.00 21.41  ? 31  TYR A CE2  1 
ATOM   465  C CZ   . TYR A 1 67  ? 7.574   -18.211 -9.250  1.00 21.18  ? 31  TYR A CZ   1 
ATOM   466  O OH   . TYR A 1 67  ? 6.512   -19.009 -9.662  1.00 22.05  ? 31  TYR A OH   1 
ATOM   467  H H    . TYR A 1 67  ? 10.922  -15.324 -5.340  1.00 18.87  ? 31  TYR A H    1 
ATOM   468  H HA   . TYR A 1 67  ? 11.685  -17.369 -6.974  1.00 18.77  ? 31  TYR A HA   1 
ATOM   469  H HB2  . TYR A 1 67  ? 10.520  -14.946 -7.733  1.00 18.17  ? 31  TYR A HB2  1 
ATOM   470  H HB3  . TYR A 1 67  ? 11.466  -15.723 -8.747  1.00 18.17  ? 31  TYR A HB3  1 
ATOM   471  H HD1  . TYR A 1 67  ? 8.640   -16.482 -6.731  1.00 21.47  ? 31  TYR A HD1  1 
ATOM   472  H HD2  . TYR A 1 67  ? 10.407  -17.103 -10.262 1.00 31.03  ? 31  TYR A HD2  1 
ATOM   473  H HE1  . TYR A 1 67  ? 6.871   -17.831 -7.390  1.00 23.32  ? 31  TYR A HE1  1 
ATOM   474  H HE2  . TYR A 1 67  ? 8.621   -18.385 -10.951 1.00 25.68  ? 31  TYR A HE2  1 
ATOM   475  H HH   . TYR A 1 67  ? 6.611   -19.226 -10.468 1.00 26.45  ? 31  TYR A HH   1 
ATOM   476  N N    . MET A 1 68  ? 13.957  -16.386 -7.459  1.00 14.07  ? 32  MET A N    1 
ATOM   477  C CA   . MET A 1 68  ? 15.294  -15.809 -7.529  1.00 15.99  ? 32  MET A CA   1 
ATOM   478  C C    . MET A 1 68  ? 15.928  -16.259 -8.827  1.00 18.89  ? 32  MET A C    1 
ATOM   479  O O    . MET A 1 68  ? 15.910  -17.446 -9.167  1.00 19.83  ? 32  MET A O    1 
ATOM   480  C CB   . MET A 1 68  ? 16.071  -16.185 -6.270  1.00 17.50  ? 32  MET A CB   1 
ATOM   481  C CG   . MET A 1 68  ? 17.532  -16.027 -6.233  1.00 14.65  ? 32  MET A CG   1 
ATOM   482  S SD   . MET A 1 68  ? 18.014  -16.003 -4.469  1.00 14.94  ? 32  MET A SD   1 
ATOM   483  C CE   . MET A 1 68  ? 19.645  -15.333 -4.812  1.00 19.76  ? 32  MET A CE   1 
ATOM   484  H H    . MET A 1 68  ? 13.862  -17.126 -7.887  1.00 16.87  ? 32  MET A H    1 
ATOM   485  H HA   . MET A 1 68  ? 15.286  -14.840 -7.558  1.00 19.18  ? 32  MET A HA   1 
ATOM   486  H HB2  . MET A 1 68  ? 15.723  -15.642 -5.545  1.00 20.99  ? 32  MET A HB2  1 
ATOM   487  H HB3  . MET A 1 68  ? 15.898  -17.123 -6.094  1.00 20.99  ? 32  MET A HB3  1 
ATOM   488  H HG2  . MET A 1 68  ? 17.965  -16.772 -6.678  1.00 17.57  ? 32  MET A HG2  1 
ATOM   489  H HG3  . MET A 1 68  ? 17.793  -15.192 -6.652  1.00 17.57  ? 32  MET A HG3  1 
ATOM   490  H HE1  . MET A 1 68  ? 20.119  -15.212 -3.974  1.00 23.70  ? 32  MET A HE1  1 
ATOM   491  H HE2  . MET A 1 68  ? 20.129  -15.954 -5.379  1.00 23.70  ? 32  MET A HE2  1 
ATOM   492  H HE3  . MET A 1 68  ? 19.547  -14.480 -5.263  1.00 23.70  ? 32  MET A HE3  1 
ATOM   493  N N    . PHE A 1 69  ? 16.436  -15.290 -9.579  1.00 16.16  ? 33  PHE A N    1 
ATOM   494  C CA   . PHE A 1 69  ? 16.808  -15.563 -10.960 1.00 17.00  ? 33  PHE A CA   1 
ATOM   495  C C    . PHE A 1 69  ? 17.697  -14.440 -11.447 1.00 20.08  ? 33  PHE A C    1 
ATOM   496  O O    . PHE A 1 69  ? 17.641  -13.315 -10.950 1.00 17.84  ? 33  PHE A O    1 
ATOM   497  C CB   . PHE A 1 69  ? 15.574  -15.677 -11.847 1.00 20.51  ? 33  PHE A CB   1 
ATOM   498  C CG   . PHE A 1 69  ? 14.638  -14.558 -11.648 1.00 21.99  ? 33  PHE A CG   1 
ATOM   499  C CD1  . PHE A 1 69  ? 14.808  -13.375 -12.330 1.00 17.19  ? 33  PHE A CD1  1 
ATOM   500  C CD2  . PHE A 1 69  ? 13.640  -14.645 -10.709 1.00 17.80  ? 33  PHE A CD2  1 
ATOM   501  C CE1  . PHE A 1 69  ? 13.977  -12.312 -12.117 1.00 19.44  ? 33  PHE A CE1  1 
ATOM   502  C CE2  . PHE A 1 69  ? 12.802  -13.576 -10.478 1.00 20.62  ? 33  PHE A CE2  1 
ATOM   503  C CZ   . PHE A 1 69  ? 12.974  -12.396 -11.192 1.00 21.20  ? 33  PHE A CZ   1 
ATOM   504  H H    . PHE A 1 69  ? 16.572  -14.482 -9.318  1.00 19.38  ? 33  PHE A H    1 
ATOM   505  H HA   . PHE A 1 69  ? 17.304  -16.395 -11.005 1.00 20.39  ? 33  PHE A HA   1 
ATOM   506  H HB2  . PHE A 1 69  ? 15.850  -15.679 -12.777 1.00 24.60  ? 33  PHE A HB2  1 
ATOM   507  H HB3  . PHE A 1 69  ? 15.107  -16.502 -11.638 1.00 24.60  ? 33  PHE A HB3  1 
ATOM   508  H HD1  . PHE A 1 69  ? 15.499  -13.298 -12.948 1.00 20.62  ? 33  PHE A HD1  1 
ATOM   509  H HD2  . PHE A 1 69  ? 13.530  -15.431 -10.225 1.00 21.35  ? 33  PHE A HD2  1 
ATOM   510  H HE1  . PHE A 1 69  ? 14.094  -11.527 -12.602 1.00 23.31  ? 33  PHE A HE1  1 
ATOM   511  H HE2  . PHE A 1 69  ? 12.123  -13.644 -9.846  1.00 24.73  ? 33  PHE A HE2  1 
ATOM   512  H HZ   . PHE A 1 69  ? 12.412  -11.671 -11.042 1.00 25.43  ? 33  PHE A HZ   1 
ATOM   513  N N    . GLY A 1 70  ? 18.497  -14.757 -12.446 1.00 20.16  ? 34  GLY A N    1 
ATOM   514  C CA   . GLY A 1 70  ? 19.173  -13.710 -13.190 1.00 21.96  ? 34  GLY A CA   1 
ATOM   515  C C    . GLY A 1 70  ? 19.642  -14.318 -14.488 1.00 21.21  ? 34  GLY A C    1 
ATOM   516  O O    . GLY A 1 70  ? 19.655  -15.536 -14.664 1.00 19.88  ? 34  GLY A O    1 
ATOM   517  H H    . GLY A 1 70  ? 18.664  -15.558 -12.710 1.00 24.18  ? 34  GLY A H    1 
ATOM   518  H HA2  . GLY A 1 70  ? 18.567  -12.975 -13.373 1.00 26.35  ? 34  GLY A HA2  1 
ATOM   519  H HA3  . GLY A 1 70  ? 19.935  -13.374 -12.692 1.00 26.35  ? 34  GLY A HA3  1 
ATOM   520  N N    . ASP A 1 71  ? 20.029  -13.434 -15.393 1.00 21.14  ? 35  ASP A N    1 
ATOM   521  C CA   . ASP A 1 71  ? 20.550  -13.810 -16.700 1.00 22.05  ? 35  ASP A CA   1 
ATOM   522  C C    . ASP A 1 71  ? 21.628  -12.796 -17.048 1.00 20.55  ? 35  ASP A C    1 
ATOM   523  O O    . ASP A 1 71  ? 21.340  -11.612 -17.176 1.00 20.80  ? 35  ASP A O    1 
ATOM   524  C CB   . ASP A 1 71  ? 19.456  -13.805 -17.747 1.00 18.96  ? 35  ASP A CB   1 
ATOM   525  C CG   . ASP A 1 71  ? 19.864  -14.541 -18.987 1.00 27.73  ? 35  ASP A CG   1 
ATOM   526  O OD1  . ASP A 1 71  ? 20.991  -14.274 -19.467 1.00 24.87  ? 35  ASP A OD1  1 
ATOM   527  O OD2  . ASP A 1 71  ? 19.082  -15.394 -19.451 1.00 26.51  ? 35  ASP A OD2  1 
ATOM   528  H H    . ASP A 1 71  ? 19.999  -12.583 -15.271 1.00 25.36  ? 35  ASP A H    1 
ATOM   529  H HA   . ASP A 1 71  ? 20.936  -14.699 -16.667 1.00 26.46  ? 35  ASP A HA   1 
ATOM   530  H HB2  . ASP A 1 71  ? 18.666  -14.234 -17.384 1.00 22.74  ? 35  ASP A HB2  1 
ATOM   531  H HB3  . ASP A 1 71  ? 19.253  -12.888 -17.991 1.00 22.74  ? 35  ASP A HB3  1 
ATOM   532  N N    . THR A 1 72  ? 22.870  -13.252 -17.134 1.00 21.38  ? 36  THR A N    1 
ATOM   533  C CA   . THR A 1 72  ? 23.944  -12.349 -17.479 1.00 20.94  ? 36  THR A CA   1 
ATOM   534  C C    . THR A 1 72  ? 23.699  -11.686 -18.819 1.00 21.34  ? 36  THR A C    1 
ATOM   535  O O    . THR A 1 72  ? 24.124  -10.547 -19.037 1.00 22.49  ? 36  THR A O    1 
ATOM   536  C CB   . THR A 1 72  ? 25.275  -13.093 -17.543 1.00 24.63  ? 36  THR A CB   1 
ATOM   537  O OG1  . THR A 1 72  ? 25.412  -13.914 -16.382 1.00 27.82  ? 36  THR A OG1  1 
ATOM   538  C CG2  . THR A 1 72  ? 26.389  -12.082 -17.607 1.00 25.90  ? 36  THR A CG2  1 
ATOM   539  H H    . THR A 1 72  ? 23.109  -14.067 -16.999 1.00 25.64  ? 36  THR A H    1 
ATOM   540  H HA   . THR A 1 72  ? 23.997  -11.671 -16.787 1.00 25.12  ? 36  THR A HA   1 
ATOM   541  H HB   . THR A 1 72  ? 25.323  -13.662 -18.326 1.00 29.55  ? 36  THR A HB   1 
ATOM   542  H HG1  . THR A 1 72  ? 24.852  -14.539 -16.405 1.00 33.37  ? 36  THR A HG1  1 
ATOM   543  H HG21 . THR A 1 72  ? 27.245  -12.524 -17.496 1.00 31.07  ? 36  THR A HG21 1 
ATOM   544  H HG22 . THR A 1 72  ? 26.377  -11.630 -18.465 1.00 31.07  ? 36  THR A HG22 1 
ATOM   545  H HG23 . THR A 1 72  ? 26.281  -11.424 -16.903 1.00 31.07  ? 36  THR A HG23 1 
ATOM   546  N N    . THR A 1 73  ? 23.018  -12.375 -19.714 1.00 22.19  ? 37  THR A N    1 
ATOM   547  C CA   . THR A 1 73  ? 22.956  -11.974 -21.112 1.00 22.25  ? 37  THR A CA   1 
ATOM   548  C C    . THR A 1 73  ? 21.793  -11.053 -21.453 1.00 28.19  ? 37  THR A C    1 
ATOM   549  O O    . THR A 1 73  ? 21.742  -10.533 -22.572 1.00 28.98  ? 37  THR A O    1 
ATOM   550  C CB   . THR A 1 73  ? 22.835  -13.208 -22.002 1.00 24.79  ? 37  THR A CB   1 
ATOM   551  O OG1  . THR A 1 73  ? 21.500  -13.729 -21.881 1.00 26.27  ? 37  THR A OG1  1 
ATOM   552  C CG2  . THR A 1 73  ? 23.810  -14.254 -21.613 1.00 29.24  ? 37  THR A CG2  1 
ATOM   553  H H    . THR A 1 73  ? 22.575  -13.090 -19.537 1.00 26.62  ? 37  THR A H    1 
ATOM   554  H HA   . THR A 1 73  ? 23.781  -11.503 -21.310 1.00 26.68  ? 37  THR A HA   1 
ATOM   555  H HB   . THR A 1 73  ? 23.022  -12.966 -22.923 1.00 29.73  ? 37  THR A HB   1 
ATOM   556  H HG1  . THR A 1 73  ? 21.353  -13.962 -21.088 1.00 31.51  ? 37  THR A HG1  1 
ATOM   557  H HG21 . THR A 1 73  ? 23.836  -14.951 -22.287 1.00 35.08  ? 37  THR A HG21 1 
ATOM   558  H HG22 . THR A 1 73  ? 24.695  -13.866 -21.527 1.00 35.08  ? 37  THR A HG22 1 
ATOM   559  H HG23 . THR A 1 73  ? 23.554  -14.647 -20.764 1.00 35.08  ? 37  THR A HG23 1 
ATOM   560  N N    . ARG A 1 74  ? 20.846  -10.845 -20.553 1.00 25.03  ? 38  ARG A N    1 
ATOM   561  C CA   . ARG A 1 74  ? 19.667  -10.107 -20.963 1.00 26.38  ? 38  ARG A CA   1 
ATOM   562  C C    . ARG A 1 74  ? 18.818  -9.749  -19.758 1.00 28.34  ? 38  ARG A C    1 
ATOM   563  O O    . ARG A 1 74  ? 18.837  -10.422 -18.732 1.00 23.91  ? 38  ARG A O    1 
ATOM   564  C CB   . ARG A 1 74  ? 18.824  -10.921 -21.963 1.00 27.05  ? 38  ARG A CB   1 
ATOM   565  C CG   . ARG A 1 74  ? 18.269  -12.258 -21.407 1.00 28.42  ? 38  ARG A CG   1 
ATOM   566  C CD   . ARG A 1 74  ? 17.273  -12.822 -22.372 1.00 28.26  ? 38  ARG A CD   1 
ATOM   567  N NE   . ARG A 1 74  ? 16.513  -13.951 -21.851 1.00 30.76  ? 38  ARG A NE   1 
ATOM   568  C CZ   . ARG A 1 74  ? 15.269  -13.874 -21.395 1.00 28.93  ? 38  ARG A CZ   1 
ATOM   569  N NH1  . ARG A 1 74  ? 14.652  -12.713 -21.250 1.00 24.91  ? 38  ARG A NH1  1 
ATOM   570  N NH2  . ARG A 1 74  ? 14.627  -14.993 -21.069 1.00 34.49  ? 38  ARG A NH2  1 
ATOM   571  H H    . ARG A 1 74  ? 20.863  -11.111 -19.735 1.00 30.02  ? 38  ARG A H    1 
ATOM   572  H HA   . ARG A 1 74  ? 19.959  -9.277  -21.371 1.00 31.64  ? 38  ARG A HA   1 
ATOM   573  H HB2  . ARG A 1 74  ? 18.066  -10.382 -22.237 1.00 32.44  ? 38  ARG A HB2  1 
ATOM   574  H HB3  . ARG A 1 74  ? 19.376  -11.132 -22.732 1.00 32.44  ? 38  ARG A HB3  1 
ATOM   575  H HG2  . ARG A 1 74  ? 18.992  -12.894 -21.295 1.00 34.09  ? 38  ARG A HG2  1 
ATOM   576  H HG3  . ARG A 1 74  ? 17.828  -12.104 -20.556 1.00 34.09  ? 38  ARG A HG3  1 
ATOM   577  H HD2  . ARG A 1 74  ? 16.640  -12.126 -22.609 1.00 33.90  ? 38  ARG A HD2  1 
ATOM   578  H HD3  . ARG A 1 74  ? 17.744  -13.125 -23.164 1.00 33.90  ? 38  ARG A HD3  1 
ATOM   579  H HE   . ARG A 1 74  ? 16.898  -14.720 -21.838 1.00 36.90  ? 38  ARG A HE   1 
ATOM   580  H HH11 . ARG A 1 74  ? 15.057  -11.982 -21.453 1.00 29.89  ? 38  ARG A HH11 1 
ATOM   581  H HH12 . ARG A 1 74  ? 13.845  -12.688 -20.953 1.00 29.89  ? 38  ARG A HH12 1 
ATOM   582  H HH21 . ARG A 1 74  ? 15.019  -15.754 -21.154 1.00 41.38  ? 38  ARG A HH21 1 
ATOM   583  H HH22 . ARG A 1 74  ? 13.821  -14.956 -20.772 1.00 41.38  ? 38  ARG A HH22 1 
ATOM   584  N N    . LEU A 1 75  ? 18.041  -8.693  -19.927 1.00 24.38  ? 39  LEU A N    1 
ATOM   585  C CA   . LEU A 1 75  ? 16.980  -8.369  -19.005 1.00 22.44  ? 39  LEU A CA   1 
ATOM   586  C C    . LEU A 1 75  ? 15.733  -9.200  -19.293 1.00 24.70  ? 39  LEU A C    1 
ATOM   587  O O    . LEU A 1 75  ? 15.555  -9.769  -20.374 1.00 23.21  ? 39  LEU A O    1 
ATOM   588  C CB   . LEU A 1 75  ? 16.627  -6.895  -19.110 1.00 21.48  ? 39  LEU A CB   1 
ATOM   589  C CG   . LEU A 1 75  ? 17.842  -5.983  -18.972 1.00 25.45  ? 39  LEU A CG   1 
ATOM   590  C CD1  . LEU A 1 75  ? 17.469  -4.556  -19.250 1.00 24.24  ? 39  LEU A CD1  1 
ATOM   591  C CD2  . LEU A 1 75  ? 18.412  -6.141  -17.571 1.00 25.87  ? 39  LEU A CD2  1 
ATOM   592  H H    . LEU A 1 75  ? 18.112  -8.140  -20.582 1.00 29.25  ? 39  LEU A H    1 
ATOM   593  H HA   . LEU A 1 75  ? 17.285  -8.565  -18.105 1.00 26.91  ? 39  LEU A HA   1 
ATOM   594  H HB2  . LEU A 1 75  ? 16.223  -6.729  -19.976 1.00 25.76  ? 39  LEU A HB2  1 
ATOM   595  H HB3  . LEU A 1 75  ? 16.000  -6.671  -18.404 1.00 25.76  ? 39  LEU A HB3  1 
ATOM   596  H HG   . LEU A 1 75  ? 18.522  -6.226  -19.619 1.00 30.53  ? 39  LEU A HG   1 
ATOM   597  H HD11 . LEU A 1 75  ? 18.121  -3.972  -18.833 1.00 29.08  ? 39  LEU A HD11 1 
ATOM   598  H HD12 . LEU A 1 75  ? 17.463  -4.413  -20.210 1.00 29.08  ? 39  LEU A HD12 1 
ATOM   599  H HD13 . LEU A 1 75  ? 16.588  -4.383  -18.884 1.00 29.08  ? 39  LEU A HD13 1 
ATOM   600  H HD21 . LEU A 1 75  ? 19.088  -5.462  -17.427 1.00 31.03  ? 39  LEU A HD21 1 
ATOM   601  H HD22 . LEU A 1 75  ? 17.695  -6.038  -16.925 1.00 31.03  ? 39  LEU A HD22 1 
ATOM   602  H HD23 . LEU A 1 75  ? 18.806  -7.024  -17.489 1.00 31.03  ? 39  LEU A HD23 1 
ATOM   603  N N    . LEU A 1 76  ? 14.822  -9.201  -18.324 1.00 25.44  ? 40  LEU A N    1 
ATOM   604  C CA   . LEU A 1 76  ? 13.530  -9.849  -18.511 1.00 23.74  ? 40  LEU A CA   1 
ATOM   605  C C    . LEU A 1 76  ? 12.714  -9.116  -19.573 1.00 21.72  ? 40  LEU A C    1 
ATOM   606  O O    . LEU A 1 76  ? 12.735  -7.879  -19.649 1.00 20.71  ? 40  LEU A O    1 
ATOM   607  C CB   . LEU A 1 76  ? 12.761  -9.854  -17.199 1.00 20.48  ? 40  LEU A CB   1 
ATOM   608  C CG   . LEU A 1 76  ? 12.983  -11.122 -16.360 1.00 23.57  ? 40  LEU A CG   1 
ATOM   609  C CD1  . LEU A 1 76  ? 14.408  -11.260 -15.924 1.00 26.84  ? 40  LEU A CD1  1 
ATOM   610  C CD2  . LEU A 1 76  ? 12.074  -11.132 -15.176 1.00 19.22  ? 40  LEU A CD2  1 
ATOM   611  H H    . LEU A 1 76  ? 14.928  -8.836  -17.552 1.00 30.51  ? 40  LEU A H    1 
ATOM   612  H HA   . LEU A 1 76  ? 13.665  -10.764 -18.801 1.00 28.48  ? 40  LEU A HA   1 
ATOM   613  H HB2  . LEU A 1 76  ? 13.045  -9.093  -16.669 1.00 24.56  ? 40  LEU A HB2  1 
ATOM   614  H HB3  . LEU A 1 76  ? 11.813  -9.789  -17.393 1.00 24.56  ? 40  LEU A HB3  1 
ATOM   615  H HG   . LEU A 1 76  ? 12.777  -11.888 -16.917 1.00 28.27  ? 40  LEU A HG   1 
ATOM   616  H HD11 . LEU A 1 76  ? 14.488  -12.038 -15.350 1.00 32.20  ? 40  LEU A HD11 1 
ATOM   617  H HD12 . LEU A 1 76  ? 14.969  -11.367 -16.708 1.00 32.20  ? 40  LEU A HD12 1 
ATOM   618  H HD13 . LEU A 1 76  ? 14.668  -10.462 -15.437 1.00 32.20  ? 40  LEU A HD13 1 
ATOM   619  H HD21 . LEU A 1 76  ? 12.239  -11.935 -14.658 1.00 23.06  ? 40  LEU A HD21 1 
ATOM   620  H HD22 . LEU A 1 76  ? 12.253  -10.347 -14.634 1.00 23.06  ? 40  LEU A HD22 1 
ATOM   621  H HD23 . LEU A 1 76  ? 11.155  -11.119 -15.483 1.00 23.06  ? 40  LEU A HD23 1 
ATOM   622  N N    . GLU A 1 77  ? 11.971  -9.883  -20.377 1.00 22.71  ? 41  GLU A N    1 
ATOM   623  C CA   . GLU A 1 77  ? 10.940  -9.283  -21.221 1.00 24.87  ? 41  GLU A CA   1 
ATOM   624  C C    . GLU A 1 77  ? 9.738   -8.869  -20.363 1.00 22.66  ? 41  GLU A C    1 
ATOM   625  O O    . GLU A 1 77  ? 9.443   -9.501  -19.348 1.00 23.11  ? 41  GLU A O    1 
ATOM   626  C CB   . GLU A 1 77  ? 10.471  -10.267 -22.295 1.00 26.13  ? 41  GLU A CB   1 
ATOM   627  C CG   . GLU A 1 77  ? 11.535  -10.721 -23.263 1.00 24.14  ? 41  GLU A CG   1 
ATOM   628  C CD   . GLU A 1 77  ? 12.090  -9.579  -24.094 1.00 31.31  ? 41  GLU A CD   1 
ATOM   629  O OE1  . GLU A 1 77  ? 11.380  -8.553  -24.260 1.00 30.38  ? 41  GLU A OE1  1 
ATOM   630  O OE2  . GLU A 1 77  ? 13.246  -9.713  -24.574 1.00 30.92  ? 41  GLU A OE2  1 
ATOM   631  H H    . GLU A 1 77  ? 12.044  -10.737 -20.449 1.00 27.24  ? 41  GLU A H    1 
ATOM   632  H HA   . GLU A 1 77  ? 11.304  -8.501  -21.663 1.00 29.84  ? 41  GLU A HA   1 
ATOM   633  H HB2  . GLU A 1 77  ? 10.125  -11.059 -21.854 1.00 31.35  ? 41  GLU A HB2  1 
ATOM   634  H HB3  . GLU A 1 77  ? 9.770   -9.843  -22.813 1.00 31.35  ? 41  GLU A HB3  1 
ATOM   635  H HG2  . GLU A 1 77  ? 12.269  -11.115 -22.766 1.00 28.95  ? 41  GLU A HG2  1 
ATOM   636  H HG3  . GLU A 1 77  ? 11.154  -11.376 -23.868 1.00 28.95  ? 41  GLU A HG3  1 
ATOM   637  N N    . PRO A 1 78  ? 9.020   -7.820  -20.746 1.00 24.39  ? 42  PRO A N    1 
ATOM   638  C CA   . PRO A 1 78  ? 7.824   -7.456  -19.970 1.00 26.36  ? 42  PRO A CA   1 
ATOM   639  C C    . PRO A 1 78  ? 6.919   -8.631  -19.679 1.00 24.35  ? 42  PRO A C    1 
ATOM   640  O O    . PRO A 1 78  ? 6.360   -8.715  -18.582 1.00 26.70  ? 42  PRO A O    1 
ATOM   641  C CB   . PRO A 1 78  ? 7.137   -6.426  -20.870 1.00 28.73  ? 42  PRO A CB   1 
ATOM   642  C CG   . PRO A 1 78  ? 8.241   -5.778  -21.554 1.00 28.44  ? 42  PRO A CG   1 
ATOM   643  C CD   . PRO A 1 78  ? 9.285   -6.823  -21.801 1.00 31.29  ? 42  PRO A CD   1 
ATOM   644  H HA   . PRO A 1 78  ? 8.088   -7.037  -19.136 1.00 31.62  ? 42  PRO A HA   1 
ATOM   645  H HB2  . PRO A 1 78  ? 6.546   -6.871  -21.498 1.00 34.47  ? 42  PRO A HB2  1 
ATOM   646  H HB3  . PRO A 1 78  ? 6.635   -5.793  -20.333 1.00 34.47  ? 42  PRO A HB3  1 
ATOM   647  H HG2  . PRO A 1 78  ? 7.927   -5.408  -22.394 1.00 34.12  ? 42  PRO A HG2  1 
ATOM   648  H HG3  . PRO A 1 78  ? 8.596   -5.071  -20.993 1.00 34.12  ? 42  PRO A HG3  1 
ATOM   649  H HD2  . PRO A 1 78  ? 9.179   -7.215  -22.681 1.00 37.54  ? 42  PRO A HD2  1 
ATOM   650  H HD3  . PRO A 1 78  ? 10.175  -6.450  -21.708 1.00 37.54  ? 42  PRO A HD3  1 
ATOM   651  N N    . GLU A 1 79  ? 6.792   -9.563  -20.626 1.00 24.10  ? 43  GLU A N    1 
ATOM   652  C CA   . GLU A 1 79  ? 5.902   -10.698 -20.425 1.00 25.29  ? 43  GLU A CA   1 
ATOM   653  C C    . GLU A 1 79  ? 6.428   -11.610 -19.340 1.00 24.78  ? 43  GLU A C    1 
ATOM   654  O O    . GLU A 1 79  ? 5.653   -12.272 -18.641 1.00 23.73  ? 43  GLU A O    1 
ATOM   655  C CB   . GLU A 1 79  ? 5.736   -11.476 -21.724 1.00 32.63  ? 43  GLU A CB   1 
ATOM   656  C CG   . GLU A 1 79  ? 4.990   -10.705 -22.804 1.00 34.80  ? 43  GLU A CG   1 
ATOM   657  C CD   . GLU A 1 79  ? 5.798   -9.564  -23.395 1.00 32.33  ? 43  GLU A CD   1 
ATOM   658  O OE1  . GLU A 1 79  ? 7.060   -9.581  -23.323 1.00 25.81  ? 43  GLU A OE1  1 
ATOM   659  O OE2  . GLU A 1 79  ? 5.163   -8.634  -23.938 1.00 37.52  ? 43  GLU A OE2  1 
ATOM   660  H H    . GLU A 1 79  ? 7.205   -9.558  -21.381 1.00 28.91  ? 43  GLU A H    1 
ATOM   661  H HA   . GLU A 1 79  ? 5.028   -10.371 -20.161 1.00 30.34  ? 43  GLU A HA   1 
ATOM   662  H HB2  . GLU A 1 79  ? 6.615   -11.696 -22.070 1.00 39.15  ? 43  GLU A HB2  1 
ATOM   663  H HB3  . GLU A 1 79  ? 5.239   -12.288 -21.541 1.00 39.15  ? 43  GLU A HB3  1 
ATOM   664  H HG2  . GLU A 1 79  ? 4.763   -11.314 -23.524 1.00 41.74  ? 43  GLU A HG2  1 
ATOM   665  H HG3  . GLU A 1 79  ? 4.182   -10.330 -22.420 1.00 41.74  ? 43  GLU A HG3  1 
ATOM   666  N N    . GLU A 1 80  ? 7.747   -11.659 -19.200 1.00 20.90  ? 44  GLU A N    1 
ATOM   667  C CA   . GLU A 1 80  ? 8.347   -12.482 -18.172 1.00 19.86  ? 44  GLU A CA   1 
ATOM   668  C C    . GLU A 1 80  ? 8.212   -11.821 -16.812 1.00 20.92  ? 44  GLU A C    1 
ATOM   669  O O    . GLU A 1 80  ? 8.039   -12.510 -15.807 1.00 21.07  ? 44  GLU A O    1 
ATOM   670  C CB   . GLU A 1 80  ? 9.812   -12.717 -18.530 1.00 22.29  ? 44  GLU A CB   1 
ATOM   671  C CG   . GLU A 1 80  ? 10.018  -13.490 -19.822 1.00 24.12  ? 44  GLU A CG   1 
ATOM   672  C CD   . GLU A 1 80  ? 11.465  -13.585 -20.230 1.00 23.00  ? 44  GLU A CD   1 
ATOM   673  O OE1  . GLU A 1 80  ? 12.169  -12.591 -20.043 1.00 25.08  ? 44  GLU A OE1  1 
ATOM   674  O OE2  . GLU A 1 80  ? 11.874  -14.656 -20.749 1.00 25.76  ? 44  GLU A OE2  1 
ATOM   675  H H    . GLU A 1 80  ? 8.310   -11.227 -19.685 1.00 25.07  ? 44  GLU A H    1 
ATOM   676  H HA   . GLU A 1 80  ? 7.907   -13.345 -18.124 1.00 23.82  ? 44  GLU A HA   1 
ATOM   677  H HB2  . GLU A 1 80  ? 10.250  -11.857 -18.627 1.00 26.74  ? 44  GLU A HB2  1 
ATOM   678  H HB3  . GLU A 1 80  ? 10.229  -13.223 -17.815 1.00 26.74  ? 44  GLU A HB3  1 
ATOM   679  H HG2  . GLU A 1 80  ? 9.681   -14.392 -19.707 1.00 28.93  ? 44  GLU A HG2  1 
ATOM   680  H HG3  . GLU A 1 80  ? 9.536   -13.043 -20.535 1.00 28.93  ? 44  GLU A HG3  1 
ATOM   681  N N    . VAL A 1 81  ? 8.337   -10.491 -16.760 1.00 19.93  ? 45  VAL A N    1 
ATOM   682  C CA   . VAL A 1 81  ? 8.066   -9.772  -15.525 1.00 20.78  ? 45  VAL A CA   1 
ATOM   683  C C    . VAL A 1 81  ? 6.632   -10.020 -15.100 1.00 23.65  ? 45  VAL A C    1 
ATOM   684  O O    . VAL A 1 81  ? 6.343   -10.265 -13.924 1.00 20.77  ? 45  VAL A O    1 
ATOM   685  C CB   . VAL A 1 81  ? 8.346   -8.266  -15.710 1.00 20.78  ? 45  VAL A CB   1 
ATOM   686  C CG1  . VAL A 1 81  ? 7.986   -7.477  -14.478 1.00 21.89  ? 45  VAL A CG1  1 
ATOM   687  C CG2  . VAL A 1 81  ? 9.803   -8.050  -16.114 1.00 20.72  ? 45  VAL A CG2  1 
ATOM   688  H H    . VAL A 1 81  ? 8.575   -9.993  -17.419 1.00 23.91  ? 45  VAL A H    1 
ATOM   689  H HA   . VAL A 1 81  ? 8.658   -10.101 -14.829 1.00 24.93  ? 45  VAL A HA   1 
ATOM   690  H HB   . VAL A 1 81  ? 7.781   -7.931  -16.423 1.00 24.92  ? 45  VAL A HB   1 
ATOM   691  H HG11 . VAL A 1 81  ? 8.225   -6.547  -14.618 1.00 26.25  ? 45  VAL A HG11 1 
ATOM   692  H HG12 . VAL A 1 81  ? 7.032   -7.553  -14.321 1.00 26.25  ? 45  VAL A HG12 1 
ATOM   693  H HG13 . VAL A 1 81  ? 8.475   -7.834  -13.720 1.00 26.25  ? 45  VAL A HG13 1 
ATOM   694  H HG21 . VAL A 1 81  ? 9.980   -7.097  -16.159 1.00 24.86  ? 45  VAL A HG21 1 
ATOM   695  H HG22 . VAL A 1 81  ? 10.380  -8.463  -15.453 1.00 24.86  ? 45  VAL A HG22 1 
ATOM   696  H HG23 . VAL A 1 81  ? 9.953   -8.455  -16.983 1.00 24.86  ? 45  VAL A HG23 1 
ATOM   697  N N    . GLU A 1 82  ? 5.707   -9.959  -16.059 1.00 20.71  ? 46  GLU A N    1 
ATOM   698  C CA   . GLU A 1 82  ? 4.307   -10.205 -15.748 1.00 26.50  ? 46  GLU A CA   1 
ATOM   699  C C    . GLU A 1 82  ? 4.094   -11.609 -15.188 1.00 23.37  ? 46  GLU A C    1 
ATOM   700  O O    . GLU A 1 82  ? 3.371   -11.785 -14.199 1.00 22.54  ? 46  GLU A O    1 
ATOM   701  C CB   . GLU A 1 82  ? 3.479   -9.999  -17.017 1.00 31.94  ? 46  GLU A CB   1 
ATOM   702  C CG   . GLU A 1 82  ? 2.239   -9.187  -16.860 1.00 48.69  ? 46  GLU A CG   1 
ATOM   703  C CD   . GLU A 1 82  ? 1.535   -9.028  -18.194 1.00 55.80  ? 46  GLU A CD   1 
ATOM   704  O OE1  . GLU A 1 82  ? 0.827   -9.973  -18.618 1.00 47.18  ? 46  GLU A OE1  1 
ATOM   705  O OE2  . GLU A 1 82  ? 1.725   -7.969  -18.829 1.00 61.92  ? 46  GLU A OE2  1 
ATOM   706  H H    . GLU A 1 82  ? 5.864   -9.779  -16.886 1.00 24.84  ? 46  GLU A H    1 
ATOM   707  H HA   . GLU A 1 82  ? 4.011   -9.577  -15.070 1.00 31.79  ? 46  GLU A HA   1 
ATOM   708  H HB2  . GLU A 1 82  ? 4.035   -9.550  -17.673 1.00 38.32  ? 46  GLU A HB2  1 
ATOM   709  H HB3  . GLU A 1 82  ? 3.211   -10.870 -17.349 1.00 38.32  ? 46  GLU A HB3  1 
ATOM   710  H HG2  . GLU A 1 82  ? 1.636   -9.631  -16.244 1.00 58.41  ? 46  GLU A HG2  1 
ATOM   711  H HG3  . GLU A 1 82  ? 2.468   -8.306  -16.525 1.00 58.41  ? 46  GLU A HG3  1 
ATOM   712  N N    . PHE A 1 83  ? 4.723   -12.615 -15.801 1.00 22.81  ? 47  PHE A N    1 
ATOM   713  C CA   . PHE A 1 83  ? 4.544   -13.997 -15.367 1.00 23.06  ? 47  PHE A CA   1 
ATOM   714  C C    . PHE A 1 83  ? 4.998   -14.181 -13.922 1.00 21.49  ? 47  PHE A C    1 
ATOM   715  O O    . PHE A 1 83  ? 4.308   -14.794 -13.095 1.00 21.21  ? 47  PHE A O    1 
ATOM   716  C CB   . PHE A 1 83  ? 5.327   -14.922 -16.305 1.00 20.57  ? 47  PHE A CB   1 
ATOM   717  C CG   . PHE A 1 83  ? 5.171   -16.382 -16.006 1.00 24.04  ? 47  PHE A CG   1 
ATOM   718  C CD1  . PHE A 1 83  ? 6.042   -17.011 -15.146 1.00 27.90  ? 47  PHE A CD1  1 
ATOM   719  C CD2  . PHE A 1 83  ? 4.166   -17.138 -16.609 1.00 26.41  ? 47  PHE A CD2  1 
ATOM   720  C CE1  . PHE A 1 83  ? 5.922   -18.352 -14.864 1.00 27.42  ? 47  PHE A CE1  1 
ATOM   721  C CE2  . PHE A 1 83  ? 4.036   -18.482 -16.329 1.00 26.32  ? 47  PHE A CE2  1 
ATOM   722  C CZ   . PHE A 1 83  ? 4.921   -19.098 -15.458 1.00 26.02  ? 47  PHE A CZ   1 
ATOM   723  H H    . PHE A 1 83  ? 5.257   -12.523 -16.468 1.00 27.36  ? 47  PHE A H    1 
ATOM   724  H HA   . PHE A 1 83  ? 3.604   -14.232 -15.414 1.00 27.66  ? 47  PHE A HA   1 
ATOM   725  H HB2  . PHE A 1 83  ? 5.020   -14.775 -17.213 1.00 24.68  ? 47  PHE A HB2  1 
ATOM   726  H HB3  . PHE A 1 83  ? 6.270   -14.708 -16.235 1.00 24.68  ? 47  PHE A HB3  1 
ATOM   727  H HD1  . PHE A 1 83  ? 6.725   -16.521 -14.748 1.00 33.47  ? 47  PHE A HD1  1 
ATOM   728  H HD2  . PHE A 1 83  ? 3.579   -16.732 -17.205 1.00 31.69  ? 47  PHE A HD2  1 
ATOM   729  H HE1  . PHE A 1 83  ? 6.514   -18.758 -14.273 1.00 32.90  ? 47  PHE A HE1  1 
ATOM   730  H HE2  . PHE A 1 83  ? 3.355   -18.975 -16.725 1.00 31.57  ? 47  PHE A HE2  1 
ATOM   731  H HZ   . PHE A 1 83  ? 4.841   -20.006 -15.275 1.00 31.22  ? 47  PHE A HZ   1 
ATOM   732  N N    . ILE A 1 84  ? 6.172   -13.654 -13.603 1.00 19.22  ? 48  ILE A N    1 
ATOM   733  C CA   . ILE A 1 84  ? 6.710   -13.849 -12.266 1.00 18.89  ? 48  ILE A CA   1 
ATOM   734  C C    . ILE A 1 84  ? 5.924   -13.035 -11.260 1.00 19.88  ? 48  ILE A C    1 
ATOM   735  O O    . ILE A 1 84  ? 5.616   -13.519 -10.162 1.00 20.13  ? 48  ILE A O    1 
ATOM   736  C CB   . ILE A 1 84  ? 8.211   -13.520 -12.268 1.00 19.43  ? 48  ILE A CB   1 
ATOM   737  C CG1  . ILE A 1 84  ? 8.917   -14.549 -13.155 1.00 19.66  ? 48  ILE A CG1  1 
ATOM   738  C CG2  . ILE A 1 84  ? 8.776   -13.556 -10.866 1.00 17.14  ? 48  ILE A CG2  1 
ATOM   739  C CD1  . ILE A 1 84  ? 10.400  -14.239 -13.462 1.00 23.35  ? 48  ILE A CD1  1 
ATOM   740  H H    . ILE A 1 84  ? 6.668   -13.189 -14.131 1.00 23.05  ? 48  ILE A H    1 
ATOM   741  H HA   . ILE A 1 84  ? 6.615   -14.779 -12.005 1.00 22.65  ? 48  ILE A HA   1 
ATOM   742  H HB   . ILE A 1 84  ? 8.348   -12.624 -12.613 1.00 23.30  ? 48  ILE A HB   1 
ATOM   743  H HG12 . ILE A 1 84  ? 8.886   -15.411 -12.711 1.00 23.58  ? 48  ILE A HG12 1 
ATOM   744  H HG13 . ILE A 1 84  ? 8.448   -14.596 -14.004 1.00 23.58  ? 48  ILE A HG13 1 
ATOM   745  H HG21 . ILE A 1 84  ? 9.741   -13.467 -10.912 1.00 20.56  ? 48  ILE A HG21 1 
ATOM   746  H HG22 . ILE A 1 84  ? 8.400   -12.822 -10.355 1.00 20.56  ? 48  ILE A HG22 1 
ATOM   747  H HG23 . ILE A 1 84  ? 8.542   -14.402 -10.453 1.00 20.56  ? 48  ILE A HG23 1 
ATOM   748  H HD11 . ILE A 1 84  ? 10.729  -14.880 -14.111 1.00 28.01  ? 48  ILE A HD11 1 
ATOM   749  H HD12 . ILE A 1 84  ? 10.467  -13.340 -13.821 1.00 28.01  ? 48  ILE A HD12 1 
ATOM   750  H HD13 . ILE A 1 84  ? 10.913  -14.306 -12.641 1.00 28.01  ? 48  ILE A HD13 1 
ATOM   751  N N    . ALA A 1 85  ? 5.574   -11.807 -11.622 1.00 18.99  ? 49  ALA A N    1 
ATOM   752  C CA   . ALA A 1 85  ? 4.843   -10.919 -10.732 1.00 16.49  ? 49  ALA A CA   1 
ATOM   753  C C    . ALA A 1 85  ? 3.522   -11.550 -10.336 1.00 22.94  ? 49  ALA A C    1 
ATOM   754  O O    . ALA A 1 85  ? 3.067   -11.395 -9.200  1.00 20.96  ? 49  ALA A O    1 
ATOM   755  C CB   . ALA A 1 85  ? 4.594   -9.581  -11.417 1.00 21.97  ? 49  ALA A CB   1 
ATOM   756  H H    . ALA A 1 85  ? 5.749   -11.460 -12.389 1.00 22.78  ? 49  ALA A H    1 
ATOM   757  H HA   . ALA A 1 85  ? 5.373   -10.756 -9.936  1.00 19.77  ? 49  ALA A HA   1 
ATOM   758  H HB1  . ALA A 1 85  ? 4.127   -8.994  -10.802 1.00 26.36  ? 49  ALA A HB1  1 
ATOM   759  H HB2  . ALA A 1 85  ? 5.446   -9.189  -11.665 1.00 26.36  ? 49  ALA A HB2  1 
ATOM   760  H HB3  . ALA A 1 85  ? 4.053   -9.727  -12.209 1.00 26.36  ? 49  ALA A HB3  1 
ATOM   761  N N    . GLU A 1 86  ? 2.906   -12.284 -11.262 1.00 20.57  ? 50  GLU A N    1 
ATOM   762  C CA   . GLU A 1 86  ? 1.644   -12.959 -10.960 1.00 25.07  ? 50  GLU A CA   1 
ATOM   763  C C    . GLU A 1 86  ? 1.797   -13.975 -9.846  1.00 25.50  ? 50  GLU A C    1 
ATOM   764  O O    . GLU A 1 86  ? 0.829   -14.274 -9.144  1.00 22.89  ? 50  GLU A O    1 
ATOM   765  C CB   . GLU A 1 86  ? 1.097   -13.706 -12.183 1.00 29.47  ? 50  GLU A CB   1 
ATOM   766  C CG   . GLU A 1 86  ? -0.108  -13.083 -12.859 1.00 52.08  ? 50  GLU A CG   1 
ATOM   767  C CD   . GLU A 1 86  ? -0.164  -13.417 -14.351 1.00 54.23  ? 50  GLU A CD   1 
ATOM   768  O OE1  . GLU A 1 86  ? 0.188   -14.565 -14.724 1.00 47.52  ? 50  GLU A OE1  1 
ATOM   769  O OE2  . GLU A 1 86  ? -0.557  -12.531 -15.146 1.00 45.36  ? 50  GLU A OE2  1 
ATOM   770  H H    . GLU A 1 86  ? 3.194   -12.407 -12.063 1.00 24.68  ? 50  GLU A H    1 
ATOM   771  H HA   . GLU A 1 86  ? 1.017   -12.265 -10.701 1.00 30.08  ? 50  GLU A HA   1 
ATOM   772  H HB2  . GLU A 1 86  ? 1.803   -13.758 -12.847 1.00 35.36  ? 50  GLU A HB2  1 
ATOM   773  H HB3  . GLU A 1 86  ? 0.839   -14.598 -11.903 1.00 35.36  ? 50  GLU A HB3  1 
ATOM   774  H HG2  . GLU A 1 86  ? -0.917  -13.419 -12.443 1.00 62.48  ? 50  GLU A HG2  1 
ATOM   775  H HG3  . GLU A 1 86  ? -0.063  -12.118 -12.766 1.00 62.48  ? 50  GLU A HG3  1 
ATOM   776  N N    . ARG A 1 87  ? 2.989   -14.558 -9.708  1.00 19.04  ? 51  ARG A N    1 
ATOM   777  C CA   . ARG A 1 87  ? 3.205   -15.742 -8.897  1.00 25.19  ? 51  ARG A CA   1 
ATOM   778  C C    . ARG A 1 87  ? 3.942   -15.483 -7.594  1.00 24.74  ? 51  ARG A C    1 
ATOM   779  O O    . ARG A 1 87  ? 4.086   -16.413 -6.788  1.00 19.10  ? 51  ARG A O    1 
ATOM   780  C CB   . ARG A 1 87  ? 3.955   -16.766 -9.737  1.00 23.65  ? 51  ARG A CB   1 
ATOM   781  C CG   . ARG A 1 87  ? 3.050   -17.276 -10.874 1.00 22.84  ? 51  ARG A CG   1 
ATOM   782  C CD   . ARG A 1 87  ? 3.782   -18.066 -11.906 1.00 24.86  ? 51  ARG A CD   1 
ATOM   783  N NE   . ARG A 1 87  ? 2.834   -18.667 -12.840 1.00 26.71  ? 51  ARG A NE   1 
ATOM   784  C CZ   . ARG A 1 87  ? 2.166   -17.994 -13.767 1.00 30.03  ? 51  ARG A CZ   1 
ATOM   785  N NH1  . ARG A 1 87  ? 2.292   -16.678 -13.898 1.00 29.66  ? 51  ARG A NH1  1 
ATOM   786  N NH2  . ARG A 1 87  ? 1.345   -18.654 -14.582 1.00 33.45  ? 51  ARG A NH2  1 
ATOM   787  H H    . ARG A 1 87  ? 3.706   -14.273 -10.089 1.00 22.84  ? 51  ARG A H    1 
ATOM   788  H HA   . ARG A 1 87  ? 2.345   -16.110 -8.639  1.00 30.21  ? 51  ARG A HA   1 
ATOM   789  H HB2  . ARG A 1 87  ? 4.744   -16.356 -10.125 1.00 28.37  ? 51  ARG A HB2  1 
ATOM   790  H HB3  . ARG A 1 87  ? 4.213   -17.519 -9.181  1.00 28.37  ? 51  ARG A HB3  1 
ATOM   791  H HG2  . ARG A 1 87  ? 2.363   -17.846 -10.496 1.00 27.40  ? 51  ARG A HG2  1 
ATOM   792  H HG3  . ARG A 1 87  ? 2.644   -16.514 -11.316 1.00 27.40  ? 51  ARG A HG3  1 
ATOM   793  H HD2  . ARG A 1 87  ? 4.379   -17.484 -12.401 1.00 29.83  ? 51  ARG A HD2  1 
ATOM   794  H HD3  . ARG A 1 87  ? 4.288   -18.774 -11.478 1.00 29.83  ? 51  ARG A HD3  1 
ATOM   795  H HE   . ARG A 1 87  ? 2.699   -19.515 -12.784 1.00 32.04  ? 51  ARG A HE   1 
ATOM   796  H HH11 . ARG A 1 87  ? 2.817   -16.242 -13.374 1.00 35.58  ? 51  ARG A HH11 1 
ATOM   797  H HH12 . ARG A 1 87  ? 1.849   -16.262 -14.507 1.00 35.58  ? 51  ARG A HH12 1 
ATOM   798  H HH21 . ARG A 1 87  ? 1.253   -19.506 -14.503 1.00 40.12  ? 51  ARG A HH21 1 
ATOM   799  H HH22 . ARG A 1 87  ? 0.906   -18.229 -15.187 1.00 40.12  ? 51  ARG A HH22 1 
ATOM   800  N N    . THR A 1 88  ? 4.399   -14.255 -7.347  1.00 22.77  ? 52  THR A N    1 
ATOM   801  C CA   . THR A 1 88  ? 5.161   -14.003 -6.133  1.00 19.92  ? 52  THR A CA   1 
ATOM   802  C C    . THR A 1 88  ? 5.057   -12.549 -5.731  1.00 17.03  ? 52  THR A C    1 
ATOM   803  O O    . THR A 1 88  ? 4.799   -11.670 -6.546  1.00 19.18  ? 52  THR A O    1 
ATOM   804  C CB   . THR A 1 88  ? 6.651   -14.380 -6.295  1.00 18.91  ? 52  THR A CB   1 
ATOM   805  O OG1  . THR A 1 88  ? 7.305   -14.264 -5.025  1.00 17.97  ? 52  THR A OG1  1 
ATOM   806  C CG2  . THR A 1 88  ? 7.358   -13.482 -7.294  1.00 19.21  ? 52  THR A CG2  1 
ATOM   807  H H    . THR A 1 88  ? 4.281   -13.572 -7.855  1.00 27.31  ? 52  THR A H    1 
ATOM   808  H HA   . THR A 1 88  ? 4.769   -14.540 -5.427  1.00 23.89  ? 52  THR A HA   1 
ATOM   809  H HB   . THR A 1 88  ? 6.706   -15.289 -6.626  1.00 22.68  ? 52  THR A HB   1 
ATOM   810  H HG1  . THR A 1 88  ? 7.067   -14.893 -4.521  1.00 21.55  ? 52  THR A HG1  1 
ATOM   811  H HG21 . THR A 1 88  ? 8.257   -13.809 -7.455  1.00 23.04  ? 52  THR A HG21 1 
ATOM   812  H HG22 . THR A 1 88  ? 6.872   -13.472 -8.133  1.00 23.04  ? 52  THR A HG22 1 
ATOM   813  H HG23 . THR A 1 88  ? 7.409   -12.577 -6.949  1.00 23.04  ? 52  THR A HG23 1 
ATOM   814  N N    . ASP A 1 89  ? 5.260   -12.326 -4.438  1.00 17.07  ? 53  ASP A N    1 
ATOM   815  C CA   . ASP A 1 89  ? 5.397   -11.010 -3.850  1.00 19.89  ? 53  ASP A CA   1 
ATOM   816  C C    . ASP A 1 89  ? 6.812   -10.756 -3.343  1.00 18.98  ? 53  ASP A C    1 
ATOM   817  O O    . ASP A 1 89  ? 7.048   -9.740  -2.690  1.00 17.32  ? 53  ASP A O    1 
ATOM   818  C CB   . ASP A 1 89  ? 4.429   -10.871 -2.687  1.00 21.06  ? 53  ASP A CB   1 
ATOM   819  C CG   . ASP A 1 89  ? 2.995   -11.041 -3.128  1.00 27.41  ? 53  ASP A CG   1 
ATOM   820  O OD1  . ASP A 1 89  ? 2.562   -10.239 -3.994  1.00 27.08  ? 53  ASP A OD1  1 
ATOM   821  O OD2  . ASP A 1 89  ? 2.335   -11.976 -2.636  1.00 23.54  ? 53  ASP A OD2  1 
ATOM   822  H H    . ASP A 1 89  ? 5.325   -12.956 -3.856  1.00 20.47  ? 53  ASP A H    1 
ATOM   823  H HA   . ASP A 1 89  ? 5.183   -10.344 -4.522  1.00 23.86  ? 53  ASP A HA   1 
ATOM   824  H HB2  . ASP A 1 89  ? 4.626   -11.551 -2.024  1.00 25.26  ? 53  ASP A HB2  1 
ATOM   825  H HB3  . ASP A 1 89  ? 4.524   -9.988  -2.296  1.00 25.26  ? 53  ASP A HB3  1 
ATOM   826  N N    . PHE A 1 90  ? 7.734   -11.672 -3.593  1.00 16.44  ? 54  PHE A N    1 
ATOM   827  C CA   . PHE A 1 90  ? 9.024   -11.680 -2.900  1.00 16.13  ? 54  PHE A CA   1 
ATOM   828  C C    . PHE A 1 90  ? 10.027  -12.343 -3.834  1.00 16.02  ? 54  PHE A C    1 
ATOM   829  O O    . PHE A 1 90  ? 9.928   -13.538 -4.127  1.00 18.21  ? 54  PHE A O    1 
ATOM   830  C CB   . PHE A 1 90  ? 8.865   -12.446 -1.580  1.00 18.98  ? 54  PHE A CB   1 
ATOM   831  C CG   . PHE A 1 90  ? 10.010  -12.343 -0.619  1.00 16.26  ? 54  PHE A CG   1 
ATOM   832  C CD1  . PHE A 1 90  ? 10.959  -11.323 -0.703  1.00 17.15  ? 54  PHE A CD1  1 
ATOM   833  C CD2  . PHE A 1 90  ? 10.065  -13.214 0.468   1.00 13.33  ? 54  PHE A CD2  1 
ATOM   834  C CE1  . PHE A 1 90  ? 11.955  -11.216 0.250   1.00 17.67  ? 54  PHE A CE1  1 
ATOM   835  C CE2  . PHE A 1 90  ? 11.043  -13.114 1.415   1.00 17.10  ? 54  PHE A CE2  1 
ATOM   836  C CZ   . PHE A 1 90  ? 12.014  -12.118 1.299   1.00 16.90  ? 54  PHE A CZ   1 
ATOM   837  H H    . PHE A 1 90  ? 7.641   -12.309 -4.164  1.00 19.72  ? 54  PHE A H    1 
ATOM   838  H HA   . PHE A 1 90  ? 9.345   -10.784 -2.713  1.00 19.34  ? 54  PHE A HA   1 
ATOM   839  H HB2  . PHE A 1 90  ? 8.078   -12.106 -1.126  1.00 22.77  ? 54  PHE A HB2  1 
ATOM   840  H HB3  . PHE A 1 90  ? 8.748   -13.386 -1.788  1.00 22.77  ? 54  PHE A HB3  1 
ATOM   841  H HD1  . PHE A 1 90  ? 10.920  -10.712 -1.403  1.00 20.57  ? 54  PHE A HD1  1 
ATOM   842  H HD2  . PHE A 1 90  ? 9.419   -13.878 0.551   1.00 15.99  ? 54  PHE A HD2  1 
ATOM   843  H HE1  . PHE A 1 90  ? 12.588  -10.537 0.185   1.00 21.19  ? 54  PHE A HE1  1 
ATOM   844  H HE2  . PHE A 1 90  ? 11.063  -13.706 2.131   1.00 20.51  ? 54  PHE A HE2  1 
ATOM   845  H HZ   . PHE A 1 90  ? 12.699  -12.060 1.925   1.00 20.27  ? 54  PHE A HZ   1 
ATOM   846  N N    . LEU A 1 91  ? 10.999  -11.576 -4.322  1.00 14.61  ? 55  LEU A N    1 
ATOM   847  C CA   . LEU A 1 91  ? 12.002  -12.192 -5.165  1.00 14.15  ? 55  LEU A CA   1 
ATOM   848  C C    . LEU A 1 91  ? 13.353  -11.518 -4.997  1.00 15.18  ? 55  LEU A C    1 
ATOM   849  O O    . LEU A 1 91  ? 13.482  -10.447 -4.409  1.00 13.39  ? 55  LEU A O    1 
ATOM   850  C CB   . LEU A 1 91  ? 11.560  -12.147 -6.633  1.00 15.55  ? 55  LEU A CB   1 
ATOM   851  C CG   . LEU A 1 91  ? 11.294  -10.772 -7.274  1.00 19.35  ? 55  LEU A CG   1 
ATOM   852  C CD1  . LEU A 1 91  ? 12.606  -10.151 -7.767  1.00 17.52  ? 55  LEU A CD1  1 
ATOM   853  C CD2  . LEU A 1 91  ? 10.291  -10.880 -8.379  1.00 20.18  ? 55  LEU A CD2  1 
ATOM   854  H H    . LEU A 1 91  ? 11.090  -10.732 -4.182  1.00 17.53  ? 55  LEU A H    1 
ATOM   855  H HA   . LEU A 1 91  ? 12.118  -13.111 -4.877  1.00 16.97  ? 55  LEU A HA   1 
ATOM   856  H HB2  . LEU A 1 91  ? 12.254  -12.571 -7.162  1.00 18.64  ? 55  LEU A HB2  1 
ATOM   857  H HB3  . LEU A 1 91  ? 10.734  -12.651 -6.706  1.00 18.64  ? 55  LEU A HB3  1 
ATOM   858  H HG   . LEU A 1 91  ? 10.919  -10.177 -6.606  1.00 23.21  ? 55  LEU A HG   1 
ATOM   859  H HD11 . LEU A 1 91  ? 12.402  -9.424  -8.376  1.00 21.02  ? 55  LEU A HD11 1 
ATOM   860  H HD12 . LEU A 1 91  ? 13.102  -9.814  -7.005  1.00 21.02  ? 55  LEU A HD12 1 
ATOM   861  H HD13 . LEU A 1 91  ? 13.124  -10.831 -8.226  1.00 21.02  ? 55  LEU A HD13 1 
ATOM   862  H HD21 . LEU A 1 91  ? 10.146  -10.000 -8.761  1.00 24.21  ? 55  LEU A HD21 1 
ATOM   863  H HD22 . LEU A 1 91  ? 10.632  -11.483 -9.058  1.00 24.21  ? 55  LEU A HD22 1 
ATOM   864  H HD23 . LEU A 1 91  ? 9.459   -11.224 -8.018  1.00 24.21  ? 55  LEU A HD23 1 
ATOM   865  N N    . CYS A 1 92  ? 14.357  -12.170 -5.573  1.00 14.79  ? 56  CYS A N    1 
ATOM   866  C CA   . CYS A 1 92  ? 15.722  -11.658 -5.564  1.00 14.41  ? 56  CYS A CA   1 
ATOM   867  C C    . CYS A 1 92  ? 16.305  -11.742 -6.959  1.00 15.29  ? 56  CYS A C    1 
ATOM   868  O O    . CYS A 1 92  ? 16.193  -12.770 -7.621  1.00 16.20  ? 56  CYS A O    1 
ATOM   869  C CB   . CYS A 1 92  ? 16.558  -12.425 -4.595  1.00 14.05  ? 56  CYS A CB   1 
ATOM   870  S SG   . CYS A 1 92  ? 18.300  -11.945 -4.583  1.00 17.61  ? 56  CYS A SG   1 
ATOM   871  H H    . CYS A 1 92  ? 14.271  -12.922 -5.980  1.00 17.73  ? 56  CYS A H    1 
ATOM   872  H HA   . CYS A 1 92  ? 15.732  -10.724 -5.304  1.00 17.29  ? 56  CYS A HA   1 
ATOM   873  H HB2  . CYS A 1 92  ? 16.207  -12.283 -3.702  1.00 16.85  ? 56  CYS A HB2  1 
ATOM   874  H HB3  . CYS A 1 92  ? 16.513  -13.366 -4.824  1.00 16.85  ? 56  CYS A HB3  1 
ATOM   875  H HG   . CYS A 1 92  ? 18.381  -10.774 -4.332  1.00 21.13  ? 56  CYS A HG   1 
ATOM   876  N N    . ILE A 1 93  ? 16.972  -10.670 -7.382  1.00 14.68  ? 57  ILE A N    1 
ATOM   877  C CA   . ILE A 1 93  ? 17.723  -10.658 -8.639  1.00 13.14  ? 57  ILE A CA   1 
ATOM   878  C C    . ILE A 1 93  ? 19.147  -11.158 -8.391  1.00 16.51  ? 57  ILE A C    1 
ATOM   879  O O    . ILE A 1 93  ? 19.826  -10.696 -7.472  1.00 14.48  ? 57  ILE A O    1 
ATOM   880  C CB   . ILE A 1 93  ? 17.759  -9.247  -9.242  1.00 12.40  ? 57  ILE A CB   1 
ATOM   881  C CG1  . ILE A 1 93  ? 16.329  -8.720  -9.432  1.00 14.49  ? 57  ILE A CG1  1 
ATOM   882  C CG2  . ILE A 1 93  ? 18.545  -9.238  -10.528 1.00 15.09  ? 57  ILE A CG2  1 
ATOM   883  C CD1  . ILE A 1 93  ? 15.479  -9.592  -10.335 1.00 18.96  ? 57  ILE A CD1  1 
ATOM   884  H H    . ILE A 1 93  ? 17.007  -9.926  -6.952  1.00 17.60  ? 57  ILE A H    1 
ATOM   885  H HA   . ILE A 1 93  ? 17.288  -11.262 -9.261  1.00 15.76  ? 57  ILE A HA   1 
ATOM   886  H HB   . ILE A 1 93  ? 18.213  -8.650  -8.627  1.00 14.87  ? 57  ILE A HB   1 
ATOM   887  H HG12 . ILE A 1 93  ? 15.894  -8.675  -8.566  1.00 17.38  ? 57  ILE A HG12 1 
ATOM   888  H HG13 . ILE A 1 93  ? 16.372  -7.835  -9.828  1.00 17.38  ? 57  ILE A HG13 1 
ATOM   889  H HG21 . ILE A 1 93  ? 18.440  -8.374  -10.957 1.00 18.10  ? 57  ILE A HG21 1 
ATOM   890  H HG22 . ILE A 1 93  ? 19.481  -9.396  -10.327 1.00 18.10  ? 57  ILE A HG22 1 
ATOM   891  H HG23 . ILE A 1 93  ? 18.209  -9.938  -11.109 1.00 18.10  ? 57  ILE A HG23 1 
ATOM   892  H HD11 . ILE A 1 93  ? 14.619  -9.164  -10.469 1.00 22.74  ? 57  ILE A HD11 1 
ATOM   893  H HD12 . ILE A 1 93  ? 15.931  -9.700  -11.187 1.00 22.74  ? 57  ILE A HD12 1 
ATOM   894  H HD13 . ILE A 1 93  ? 15.357  -10.457 -9.914  1.00 22.74  ? 57  ILE A HD13 1 
ATOM   895  N N    . GLU A 1 94  ? 19.615  -12.058 -9.244  1.00 17.10  ? 58  GLU A N    1 
ATOM   896  C CA   . GLU A 1 94  ? 20.860  -12.767 -9.003  1.00 14.03  ? 58  GLU A CA   1 
ATOM   897  C C    . GLU A 1 94  ? 22.088  -11.937 -9.382  1.00 16.65  ? 58  GLU A C    1 
ATOM   898  O O    . GLU A 1 94  ? 22.006  -10.798 -9.865  1.00 20.02  ? 58  GLU A O    1 
ATOM   899  C CB   . GLU A 1 94  ? 20.838  -14.120 -9.724  1.00 15.44  ? 58  GLU A CB   1 
ATOM   900  C CG   . GLU A 1 94  ? 20.536  -15.296 -8.791  1.00 23.47  ? 58  GLU A CG   1 
ATOM   901  C CD   . GLU A 1 94  ? 21.755  -15.770 -8.011  1.00 19.54  ? 58  GLU A CD   1 
ATOM   902  O OE1  . GLU A 1 94  ? 22.826  -15.108 -8.055  1.00 19.07  ? 58  GLU A OE1  1 
ATOM   903  O OE2  . GLU A 1 94  ? 21.631  -16.790 -7.307  1.00 25.58  ? 58  GLU A OE2  1 
ATOM   904  H H    . GLU A 1 94  ? 19.225  -12.278 -9.978  1.00 20.51  ? 58  GLU A H    1 
ATOM   905  H HA   . GLU A 1 94  ? 20.930  -12.923 -8.048  1.00 16.83  ? 58  GLU A HA   1 
ATOM   906  H HB2  . GLU A 1 94  ? 20.153  -14.099 -10.410 1.00 18.52  ? 58  GLU A HB2  1 
ATOM   907  H HB3  . GLU A 1 94  ? 21.707  -14.275 -10.128 1.00 18.52  ? 58  GLU A HB3  1 
ATOM   908  H HG2  . GLU A 1 94  ? 19.859  -15.024 -8.151  1.00 28.16  ? 58  GLU A HG2  1 
ATOM   909  H HG3  . GLU A 1 94  ? 20.211  -16.042 -9.320  1.00 28.16  ? 58  GLU A HG3  1 
ATOM   910  N N    . LYS A 1 95  ? 23.245  -12.553 -9.132  1.00 14.75  ? 59  LYS A N    1 
ATOM   911  C CA   . LYS A 1 95  ? 24.538  -11.891 -8.999  1.00 13.31  ? 59  LYS A CA   1 
ATOM   912  C C    . LYS A 1 95  ? 25.057  -11.273 -10.276 1.00 17.86  ? 59  LYS A C    1 
ATOM   913  O O    . LYS A 1 95  ? 25.954  -10.433 -10.215 1.00 17.99  ? 59  LYS A O    1 
ATOM   914  C CB   . LYS A 1 95  ? 25.580  -12.903 -8.552  1.00 17.22  ? 59  LYS A CB   1 
ATOM   915  C CG   . LYS A 1 95  ? 25.747  -14.055 -9.536  1.00 20.95  ? 59  LYS A CG   1 
ATOM   916  C CD   . LYS A 1 95  ? 26.831  -15.011 -9.081  1.00 21.73  ? 59  LYS A CD   1 
ATOM   917  C CE   . LYS A 1 95  ? 26.533  -15.732 -7.775  1.00 23.78  ? 59  LYS A CE   1 
ATOM   918  N NZ   . LYS A 1 95  ? 25.238  -16.501 -7.707  1.00 26.65  ? 59  LYS A NZ   1 
ATOM   919  H H    . LYS A 1 95  ? 23.311  -13.404 -9.030  1.00 17.69  ? 59  LYS A H    1 
ATOM   920  H HA   . LYS A 1 95  ? 24.421  -11.186 -8.342  1.00 15.96  ? 59  LYS A HA   1 
ATOM   921  H HB2  . LYS A 1 95  ? 26.436  -12.456 -8.465  1.00 20.66  ? 59  LYS A HB2  1 
ATOM   922  H HB3  . LYS A 1 95  ? 25.311  -13.275 -7.697  1.00 20.66  ? 59  LYS A HB3  1 
ATOM   923  H HG2  . LYS A 1 95  ? 24.914  -14.546 -9.602  1.00 25.12  ? 59  LYS A HG2  1 
ATOM   924  H HG3  . LYS A 1 95  ? 25.995  -13.703 -10.405 1.00 25.12  ? 59  LYS A HG3  1 
ATOM   925  H HD2  . LYS A 1 95  ? 26.954  -15.687 -9.766  1.00 26.07  ? 59  LYS A HD2  1 
ATOM   926  H HD3  . LYS A 1 95  ? 27.653  -14.511 -8.958  1.00 26.07  ? 59  LYS A HD3  1 
ATOM   927  H HE2  . LYS A 1 95  ? 27.248  -16.367 -7.611  1.00 28.53  ? 59  LYS A HE2  1 
ATOM   928  H HE3  . LYS A 1 95  ? 26.507  -15.072 -7.065  1.00 28.53  ? 59  LYS A HE3  1 
ATOM   929  H HZ1  . LYS A 1 95  ? 25.150  -16.880 -6.907  1.00 31.97  ? 59  LYS A HZ1  1 
ATOM   930  H HZ2  . LYS A 1 95  ? 24.551  -15.952 -7.844  1.00 31.97  ? 59  LYS A HZ2  1 
ATOM   931  H HZ3  . LYS A 1 95  ? 25.228  -17.136 -8.330  1.00 31.97  ? 59  LYS A HZ3  1 
ATOM   932  N N    . SER A 1 96  ? 24.588  -11.719 -11.429 1.00 17.74  ? 60  SER A N    1 
ATOM   933  C CA   . SER A 1 96  ? 25.155  -11.226 -12.678 1.00 15.11  ? 60  SER A CA   1 
ATOM   934  C C    . SER A 1 96  ? 24.108  -10.632 -13.580 1.00 17.13  ? 60  SER A C    1 
ATOM   935  O O    . SER A 1 96  ? 24.375  -10.393 -14.774 1.00 20.09  ? 60  SER A O    1 
ATOM   936  C CB   . SER A 1 96  ? 25.923  -12.364 -13.377 1.00 20.49  ? 60  SER A CB   1 
ATOM   937  O OG   . SER A 1 96  ? 25.055  -13.371 -13.867 1.00 19.87  ? 60  SER A OG   1 
ATOM   938  H H    . SER A 1 96  ? 23.955  -12.295 -11.515 1.00 21.28  ? 60  SER A H    1 
ATOM   939  H HA   . SER A 1 96  ? 25.793  -10.519 -12.494 1.00 18.12  ? 60  SER A HA   1 
ATOM   940  H HB2  . SER A 1 96  ? 26.418  -11.991 -14.124 1.00 24.57  ? 60  SER A HB2  1 
ATOM   941  H HB3  . SER A 1 96  ? 26.535  -12.763 -12.739 1.00 24.57  ? 60  SER A HB3  1 
ATOM   942  H HG   . SER A 1 96  ? 25.492  -14.069 -14.037 1.00 23.83  ? 60  SER A HG   1 
ATOM   943  N N    . HIS A 1 97  ? 22.915  -10.377 -13.058 1.00 20.86  ? 61  HIS A N    1 
ATOM   944  C CA   . HIS A 1 97  ? 21.811  -10.112 -13.950 1.00 21.52  ? 61  HIS A CA   1 
ATOM   945  C C    . HIS A 1 97  ? 22.059  -8.868  -14.796 1.00 19.06  ? 61  HIS A C    1 
ATOM   946  O O    . HIS A 1 97  ? 22.378  -7.792  -14.279 1.00 19.12  ? 61  HIS A O    1 
ATOM   947  C CB   . HIS A 1 97  ? 20.523  -9.930  -13.187 1.00 17.67  ? 61  HIS A CB   1 
ATOM   948  C CG   . HIS A 1 97  ? 19.340  -9.783  -14.084 1.00 21.30  ? 61  HIS A CG   1 
ATOM   949  N ND1  . HIS A 1 97  ? 18.967  -10.766 -14.970 1.00 19.92  ? 61  HIS A ND1  1 
ATOM   950  C CD2  . HIS A 1 97  ? 18.472  -8.758  -14.268 1.00 18.08  ? 61  HIS A CD2  1 
ATOM   951  C CE1  . HIS A 1 97  ? 17.892  -10.378 -15.632 1.00 18.84  ? 61  HIS A CE1  1 
ATOM   952  N NE2  . HIS A 1 97  ? 17.572  -9.160  -15.227 1.00 17.90  ? 61  HIS A NE2  1 
ATOM   953  H H    . HIS A 1 97  ? 22.731  -10.353 -12.219 1.00 25.03  ? 61  HIS A H    1 
ATOM   954  H HA   . HIS A 1 97  ? 21.724  -10.881 -14.535 1.00 25.81  ? 61  HIS A HA   1 
ATOM   955  H HB2  . HIS A 1 97  ? 20.378  -10.704 -12.622 1.00 21.20  ? 61  HIS A HB2  1 
ATOM   956  H HB3  . HIS A 1 97  ? 20.589  -9.129  -12.643 1.00 21.20  ? 61  HIS A HB3  1 
ATOM   957  H HD2  . HIS A 1 97  ? 18.484  -7.938  -13.830 1.00 21.69  ? 61  HIS A HD2  1 
ATOM   958  H HE1  . HIS A 1 97  ? 17.438  -10.875 -16.273 1.00 22.60  ? 61  HIS A HE1  1 
ATOM   959  H HE2  . HIS A 1 97  ? 16.909  -8.696  -15.516 1.00 21.47  ? 61  HIS A HE2  1 
ATOM   960  N N    . GLY A 1 98  ? 21.861  -9.022  -16.108 1.00 24.20  ? 62  GLY A N    1 
ATOM   961  C CA   . GLY A 1 98  ? 21.955  -7.901  -17.012 1.00 22.74  ? 62  GLY A CA   1 
ATOM   962  C C    . GLY A 1 98  ? 23.345  -7.358  -17.179 1.00 21.42  ? 62  GLY A C    1 
ATOM   963  O O    . GLY A 1 98  ? 23.500  -6.282  -17.762 1.00 22.50  ? 62  GLY A O    1 
ATOM   964  H H    . GLY A 1 98  ? 21.673  -9.770  -16.489 1.00 29.03  ? 62  GLY A H    1 
ATOM   965  H HA2  . GLY A 1 98  ? 21.634  -8.176  -17.885 1.00 27.28  ? 62  GLY A HA2  1 
ATOM   966  H HA3  . GLY A 1 98  ? 21.392  -7.184  -16.680 1.00 27.28  ? 62  GLY A HA3  1 
ATOM   967  N N    . ARG A 1 99  ? 24.355  -8.088  -16.712 1.00 21.08  ? 63  ARG A N    1 
ATOM   968  C CA   . ARG A 1 99  ? 25.715  -7.571  -16.765 1.00 23.09  ? 63  ARG A CA   1 
ATOM   969  C C    . ARG A 1 99  ? 26.135  -7.285  -18.201 1.00 26.56  ? 63  ARG A C    1 
ATOM   970  O O    . ARG A 1 99  ? 26.747  -6.242  -18.488 1.00 26.11  ? 63  ARG A O    1 
ATOM   971  C CB   . ARG A 1 99  ? 26.676  -8.559  -16.117 1.00 24.06  ? 63  ARG A CB   1 
ATOM   972  H H    . ARG A 1 99  ? 24.280  -8.872  -16.367 1.00 25.28  ? 63  ARG A H    1 
ATOM   973  H HA   . ARG A 1 99  ? 25.754  -6.741  -16.264 1.00 27.69  ? 63  ARG A HA   1 
ATOM   974  N N    . THR A 1 100 ? 25.820  -8.192  -19.123 1.00 24.46  ? 64  THR A N    1 
ATOM   975  C CA   . THR A 1 100 ? 26.254  -7.952  -20.499 1.00 24.40  ? 64  THR A CA   1 
ATOM   976  C C    . THR A 1 100 ? 25.522  -6.765  -21.108 1.00 25.64  ? 64  THR A C    1 
ATOM   977  O O    . THR A 1 100 ? 26.197  -5.824  -21.563 1.00 30.79  ? 64  THR A O    1 
ATOM   978  C CB   . THR A 1 100 ? 26.115  -9.223  -21.335 1.00 29.63  ? 64  THR A CB   1 
ATOM   979  O OG1  . THR A 1 100 ? 26.911  -10.261 -20.749 1.00 27.85  ? 64  THR A OG1  1 
ATOM   980  C CG2  . THR A 1 100 ? 26.626  -8.977  -22.774 1.00 35.03  ? 64  THR A CG2  1 
ATOM   981  H H    . THR A 1 100 ? 25.379  -8.918  -18.988 1.00 29.34  ? 64  THR A H    1 
ATOM   982  H HA   . THR A 1 100 ? 27.200  -7.738  -20.484 1.00 29.27  ? 64  THR A HA   1 
ATOM   983  H HB   . THR A 1 100 ? 25.183  -9.489  -21.369 1.00 35.55  ? 64  THR A HB   1 
ATOM   984  H HG1  . THR A 1 100 ? 27.716  -10.024 -20.718 1.00 33.41  ? 64  THR A HG1  1 
ATOM   985  H HG21 . THR A 1 100 ? 26.579  -9.799  -23.288 1.00 42.03  ? 64  THR A HG21 1 
ATOM   986  H HG22 . THR A 1 100 ? 26.082  -8.302  -23.209 1.00 42.03  ? 64  THR A HG22 1 
ATOM   987  H HG23 . THR A 1 100 ? 27.547  -8.673  -22.751 1.00 42.03  ? 64  THR A HG23 1 
ATOM   988  N N    . PRO A 1 101 ? 24.185  -6.711  -21.128 1.00 25.49  ? 65  PRO A N    1 
ATOM   989  C CA   . PRO A 1 101 ? 23.512  -5.571  -21.774 1.00 27.38  ? 65  PRO A CA   1 
ATOM   990  C C    . PRO A 1 101 ? 23.695  -4.237  -21.067 1.00 33.01  ? 65  PRO A C    1 
ATOM   991  O O    . PRO A 1 101 ? 23.718  -3.195  -21.733 1.00 29.85  ? 65  PRO A O    1 
ATOM   992  C CB   . PRO A 1 101 ? 22.030  -5.985  -21.764 1.00 30.18  ? 65  PRO A CB   1 
ATOM   993  C CG   . PRO A 1 101 ? 21.931  -7.030  -20.702 1.00 25.62  ? 65  PRO A CG   1 
ATOM   994  C CD   . PRO A 1 101 ? 23.227  -7.780  -20.791 1.00 26.33  ? 65  PRO A CD   1 
ATOM   995  H HA   . PRO A 1 101 ? 23.840  -5.493  -22.683 1.00 32.85  ? 65  PRO A HA   1 
ATOM   996  H HB2  . PRO A 1 101 ? 21.474  -5.220  -21.551 1.00 36.20  ? 65  PRO A HB2  1 
ATOM   997  H HB3  . PRO A 1 101 ? 21.782  -6.345  -22.630 1.00 36.20  ? 65  PRO A HB3  1 
ATOM   998  H HG2  . PRO A 1 101 ? 21.829  -6.612  -19.833 1.00 30.73  ? 65  PRO A HG2  1 
ATOM   999  H HG3  . PRO A 1 101 ? 21.177  -7.614  -20.880 1.00 30.73  ? 65  PRO A HG3  1 
ATOM   1000 H HD2  . PRO A 1 101 ? 23.449  -8.194  -19.943 1.00 31.58  ? 65  PRO A HD2  1 
ATOM   1001 H HD3  . PRO A 1 101 ? 23.194  -8.452  -21.490 1.00 31.58  ? 65  PRO A HD3  1 
ATOM   1002 N N    . LEU A 1 102 ? 23.786  -4.218  -19.739 1.00 24.66  ? 66  LEU A N    1 
ATOM   1003 C CA   . LEU A 1 102 ? 23.863  -2.959  -19.007 1.00 27.54  ? 66  LEU A CA   1 
ATOM   1004 C C    . LEU A 1 102 ? 25.256  -2.675  -18.469 1.00 23.99  ? 66  LEU A C    1 
ATOM   1005 O O    . LEU A 1 102 ? 25.524  -1.541  -18.062 1.00 28.35  ? 66  LEU A O    1 
ATOM   1006 C CB   . LEU A 1 102 ? 22.868  -2.953  -17.840 1.00 24.80  ? 66  LEU A CB   1 
ATOM   1007 C CG   . LEU A 1 102 ? 21.376  -3.050  -18.184 1.00 28.06  ? 66  LEU A CG   1 
ATOM   1008 C CD1  . LEU A 1 102 ? 20.539  -2.838  -16.930 1.00 24.40  ? 66  LEU A CD1  1 
ATOM   1009 C CD2  . LEU A 1 102 ? 20.937  -2.051  -19.258 1.00 27.52  ? 66  LEU A CD2  1 
ATOM   1010 H H    . LEU A 1 102 ? 23.806  -4.919  -19.243 1.00 29.58  ? 66  LEU A H    1 
ATOM   1011 H HA   . LEU A 1 102 ? 23.613  -2.237  -19.605 1.00 33.04  ? 66  LEU A HA   1 
ATOM   1012 H HB2  . LEU A 1 102 ? 23.075  -3.710  -17.270 1.00 29.75  ? 66  LEU A HB2  1 
ATOM   1013 H HB3  . LEU A 1 102 ? 22.991  -2.125  -17.349 1.00 29.75  ? 66  LEU A HB3  1 
ATOM   1014 H HG   . LEU A 1 102 ? 21.224  -3.937  -18.546 1.00 33.66  ? 66  LEU A HG   1 
ATOM   1015 H HD11 . LEU A 1 102 ? 19.600  -2.902  -17.163 1.00 29.27  ? 66  LEU A HD11 1 
ATOM   1016 H HD12 . LEU A 1 102 ? 20.766  -3.522  -16.280 1.00 29.27  ? 66  LEU A HD12 1 
ATOM   1017 H HD13 . LEU A 1 102 ? 20.731  -1.960  -16.566 1.00 29.27  ? 66  LEU A HD13 1 
ATOM   1018 H HD21 . LEU A 1 102 ? 19.977  -2.119  -19.379 1.00 33.01  ? 66  LEU A HD21 1 
ATOM   1019 H HD22 . LEU A 1 102 ? 21.172  -1.155  -18.970 1.00 33.01  ? 66  LEU A HD22 1 
ATOM   1020 H HD23 . LEU A 1 102 ? 21.391  -2.261  -20.089 1.00 33.01  ? 66  LEU A HD23 1 
ATOM   1021 N N    . GLY A 1 103 ? 26.144  -3.663  -18.468 1.00 25.35  ? 67  GLY A N    1 
ATOM   1022 C CA   . GLY A 1 103 ? 27.518  -3.474  -18.066 1.00 24.15  ? 67  GLY A CA   1 
ATOM   1023 C C    . GLY A 1 103 ? 27.822  -3.761  -16.610 1.00 26.14  ? 67  GLY A C    1 
ATOM   1024 O O    . GLY A 1 103 ? 29.002  -3.861  -16.249 1.00 28.94  ? 67  GLY A O    1 
ATOM   1025 H H    . GLY A 1 103 ? 25.964  -4.470  -18.703 1.00 30.41  ? 67  GLY A H    1 
ATOM   1026 H HA2  . GLY A 1 103 ? 28.078  -4.057  -18.602 1.00 28.97  ? 67  GLY A HA2  1 
ATOM   1027 H HA3  . GLY A 1 103 ? 27.766  -2.552  -18.240 1.00 28.97  ? 67  GLY A HA3  1 
ATOM   1028 N N    . ALA A 1 104 ? 26.809  -3.880  -15.756 1.00 21.08  ? 68  ALA A N    1 
ATOM   1029 C CA   . ALA A 1 104 ? 27.050  -4.045  -14.322 1.00 20.13  ? 68  ALA A CA   1 
ATOM   1030 C C    . ALA A 1 104 ? 25.803  -4.672  -13.714 1.00 21.45  ? 68  ALA A C    1 
ATOM   1031 O O    . ALA A 1 104 ? 24.687  -4.236  -14.008 1.00 19.55  ? 68  ALA A O    1 
ATOM   1032 C CB   . ALA A 1 104 ? 27.374  -2.706  -13.639 1.00 26.41  ? 68  ALA A CB   1 
ATOM   1033 H H    . ALA A 1 104 ? 25.978  -3.870  -15.979 1.00 25.29  ? 68  ALA A H    1 
ATOM   1034 H HA   . ALA A 1 104 ? 27.808  -4.633  -14.180 1.00 24.14  ? 68  ALA A HA   1 
ATOM   1035 H HB1  . ALA A 1 104 ? 27.502  -2.859  -12.689 1.00 31.68  ? 68  ALA A HB1  1 
ATOM   1036 H HB2  . ALA A 1 104 ? 28.185  -2.342  -14.027 1.00 31.68  ? 68  ALA A HB2  1 
ATOM   1037 H HB3  . ALA A 1 104 ? 26.636  -2.093  -13.779 1.00 31.68  ? 68  ALA A HB3  1 
ATOM   1038 N N    . ALA A 1 105 ? 25.989  -5.679  -12.859 1.00 21.76  ? 69  ALA A N    1 
ATOM   1039 C CA   . ALA A 1 105 ? 24.835  -6.448  -12.383 1.00 21.14  ? 69  ALA A CA   1 
ATOM   1040 C C    . ALA A 1 105 ? 23.923  -5.644  -11.475 1.00 16.36  ? 69  ALA A C    1 
ATOM   1041 O O    . ALA A 1 105 ? 22.738  -5.978  -11.337 1.00 19.84  ? 69  ALA A O    1 
ATOM   1042 C CB   . ALA A 1 105 ? 25.286  -7.693  -11.627 1.00 22.40  ? 69  ALA A CB   1 
ATOM   1043 H H    . ALA A 1 105 ? 26.750  -5.931  -12.548 1.00 26.10  ? 69  ALA A H    1 
ATOM   1044 H HA   . ALA A 1 105 ? 24.333  -6.723  -13.166 1.00 25.36  ? 69  ALA A HA   1 
ATOM   1045 H HB1  . ALA A 1 105 ? 24.504  -8.195  -11.350 1.00 26.87  ? 69  ALA A HB1  1 
ATOM   1046 H HB2  . ALA A 1 105 ? 25.837  -8.236  -12.213 1.00 26.87  ? 69  ALA A HB2  1 
ATOM   1047 H HB3  . ALA A 1 105 ? 25.799  -7.422  -10.850 1.00 26.87  ? 69  ALA A HB3  1 
ATOM   1048 N N    . GLU A 1 106 ? 24.421  -4.592  -10.855 1.00 21.23  ? 70  GLU A N    1 
ATOM   1049 C CA   . GLU A 1 106 ? 23.505  -3.840  -10.008 1.00 19.95  ? 70  GLU A CA   1 
ATOM   1050 C C    . GLU A 1 106 ? 22.537  -3.023  -10.840 1.00 20.04  ? 70  GLU A C    1 
ATOM   1051 O O    . GLU A 1 106 ? 21.454  -2.687  -10.364 1.00 17.98  ? 70  GLU A O    1 
ATOM   1052 C CB   . GLU A 1 106 ? 24.284  -2.975  -9.024  1.00 23.17  ? 70  GLU A CB   1 
ATOM   1053 C CG   . GLU A 1 106 ? 24.777  -1.667  -9.594  1.00 20.87  ? 70  GLU A CG   1 
ATOM   1054 C CD   . GLU A 1 106 ? 26.127  -1.806  -10.258 1.00 21.41  ? 70  GLU A CD   1 
ATOM   1055 O OE1  . GLU A 1 106 ? 26.627  -2.952  -10.393 1.00 19.88  ? 70  GLU A OE1  1 
ATOM   1056 O OE2  . GLU A 1 106 ? 26.672  -0.756  -10.664 1.00 21.71  ? 70  GLU A OE2  1 
ATOM   1057 H H    . GLU A 1 106 ? 25.231  -4.307  -10.901 1.00 25.46  ? 70  GLU A H    1 
ATOM   1058 H HA   . GLU A 1 106 ? 22.977  -4.448  -9.467  1.00 23.93  ? 70  GLU A HA   1 
ATOM   1059 H HB2  . GLU A 1 106 ? 23.708  -2.768  -8.271  1.00 27.79  ? 70  GLU A HB2  1 
ATOM   1060 H HB3  . GLU A 1 106 ? 25.059  -3.473  -8.721  1.00 27.79  ? 70  GLU A HB3  1 
ATOM   1061 H HG2  . GLU A 1 106 ? 24.145  -1.351  -10.258 1.00 25.04  ? 70  GLU A HG2  1 
ATOM   1062 H HG3  . GLU A 1 106 ? 24.858  -1.018  -8.877  1.00 25.04  ? 70  GLU A HG3  1 
ATOM   1063 N N    . LEU A 1 107 ? 22.887  -2.718  -12.084 1.00 18.90  ? 71  LEU A N    1 
ATOM   1064 C CA   . LEU A 1 107 ? 21.936  -2.060  -12.964 1.00 21.28  ? 71  LEU A CA   1 
ATOM   1065 C C    . LEU A 1 107 ? 20.885  -3.045  -13.457 1.00 19.85  ? 71  LEU A C    1 
ATOM   1066 O O    . LEU A 1 107 ? 19.744  -2.659  -13.718 1.00 21.97  ? 71  LEU A O    1 
ATOM   1067 C CB   . LEU A 1 107 ? 22.681  -1.434  -14.146 1.00 17.86  ? 71  LEU A CB   1 
ATOM   1068 C CG   . LEU A 1 107 ? 23.768  -0.445  -13.741 1.00 22.37  ? 71  LEU A CG   1 
ATOM   1069 C CD1  . LEU A 1 107 ? 24.447  0.117   -14.999 1.00 26.12  ? 71  LEU A CD1  1 
ATOM   1070 C CD2  . LEU A 1 107 ? 23.215  0.673   -12.882 1.00 26.77  ? 71  LEU A CD2  1 
ATOM   1071 H H    . LEU A 1 107 ? 23.655  -2.878  -12.435 1.00 22.67  ? 71  LEU A H    1 
ATOM   1072 H HA   . LEU A 1 107 ? 21.483  -1.345  -12.490 1.00 25.52  ? 71  LEU A HA   1 
ATOM   1073 H HB2  . LEU A 1 107 ? 23.101  -2.142  -14.658 1.00 21.42  ? 71  LEU A HB2  1 
ATOM   1074 H HB3  . LEU A 1 107 ? 22.041  -0.959  -14.699 1.00 21.42  ? 71  LEU A HB3  1 
ATOM   1075 H HG   . LEU A 1 107 ? 24.432  -0.907  -13.206 1.00 26.84  ? 71  LEU A HG   1 
ATOM   1076 H HD11 . LEU A 1 107 ? 25.154  0.725   -14.731 1.00 31.33  ? 71  LEU A HD11 1 
ATOM   1077 H HD12 . LEU A 1 107 ? 24.819  -0.618  -15.511 1.00 31.33  ? 71  LEU A HD12 1 
ATOM   1078 H HD13 . LEU A 1 107 ? 23.787  0.589   -15.529 1.00 31.33  ? 71  LEU A HD13 1 
ATOM   1079 H HD21 . LEU A 1 107 ? 23.863  1.393   -12.843 1.00 32.11  ? 71  LEU A HD21 1 
ATOM   1080 H HD22 . LEU A 1 107 ? 22.388  0.994   -13.275 1.00 32.11  ? 71  LEU A HD22 1 
ATOM   1081 H HD23 . LEU A 1 107 ? 23.046  0.332   -11.990 1.00 32.11  ? 71  LEU A HD23 1 
ATOM   1082 N N    . GLY A 1 108 ? 21.266  -4.311  -13.629 1.00 18.28  ? 72  GLY A N    1 
ATOM   1083 C CA   . GLY A 1 108 ? 20.268  -5.331  -13.879 1.00 20.50  ? 72  GLY A CA   1 
ATOM   1084 C C    . GLY A 1 108 ? 19.257  -5.408  -12.759 1.00 19.38  ? 72  GLY A C    1 
ATOM   1085 O O    . GLY A 1 108 ? 18.049  -5.504  -12.992 1.00 20.41  ? 72  GLY A O    1 
ATOM   1086 H H    . GLY A 1 108 ? 22.078  -4.593  -13.605 1.00 21.92  ? 72  GLY A H    1 
ATOM   1087 H HA2  . GLY A 1 108 ? 19.800  -5.129  -14.705 1.00 24.59  ? 72  GLY A HA2  1 
ATOM   1088 H HA3  . GLY A 1 108 ? 20.702  -6.194  -13.965 1.00 24.59  ? 72  GLY A HA3  1 
ATOM   1089 N N    . ALA A 1 109 ? 19.740  -5.392  -11.519 1.00 19.33  ? 73  ALA A N    1 
ATOM   1090 C CA   . ALA A 1 109 ? 18.823  -5.392  -10.387 1.00 19.43  ? 73  ALA A CA   1 
ATOM   1091 C C    . ALA A 1 109 ? 17.975  -4.128  -10.355 1.00 17.67  ? 73  ALA A C    1 
ATOM   1092 O O    . ALA A 1 109 ? 16.756  -4.173  -10.123 1.00 17.44  ? 73  ALA A O    1 
ATOM   1093 C CB   . ALA A 1 109 ? 19.612  -5.532  -9.088  1.00 18.65  ? 73  ALA A CB   1 
ATOM   1094 H H    . ALA A 1 109 ? 20.575  -5.380  -11.312 1.00 23.19  ? 73  ALA A H    1 
ATOM   1095 H HA   . ALA A 1 109 ? 18.224  -6.151  -10.469 1.00 23.30  ? 73  ALA A HA   1 
ATOM   1096 H HB1  . ALA A 1 109 ? 19.014  -5.387  -8.338  1.00 22.37  ? 73  ALA A HB1  1 
ATOM   1097 H HB2  . ALA A 1 109 ? 19.990  -6.424  -9.043  1.00 22.37  ? 73  ALA A HB2  1 
ATOM   1098 H HB3  . ALA A 1 109 ? 20.321  -4.871  -9.078  1.00 22.37  ? 73  ALA A HB3  1 
ATOM   1099 N N    . LYS A 1 110 ? 18.587  -2.987  -10.617 1.00 18.12  ? 74  LYS A N    1 
ATOM   1100 C CA   . LYS A 1 110 ? 17.807  -1.751  -10.614 1.00 18.21  ? 74  LYS A CA   1 
ATOM   1101 C C    . LYS A 1 110 ? 16.719  -1.799  -11.677 1.00 18.36  ? 74  LYS A C    1 
ATOM   1102 O O    . LYS A 1 110 ? 15.586  -1.359  -11.446 1.00 18.72  ? 74  LYS A O    1 
ATOM   1103 C CB   . LYS A 1 110 ? 18.755  -0.573  -10.848 1.00 15.89  ? 74  LYS A CB   1 
ATOM   1104 C CG   . LYS A 1 110 ? 18.131  0.807   -10.804 1.00 20.16  ? 74  LYS A CG   1 
ATOM   1105 C CD   . LYS A 1 110 ? 19.056  1.816   -11.386 1.00 30.09  ? 74  LYS A CD   1 
ATOM   1106 C CE   . LYS A 1 110 ? 18.820  3.185   -10.789 1.00 42.08  ? 74  LYS A CE   1 
ATOM   1107 N NZ   . LYS A 1 110 ? 19.831  4.160   -11.296 1.00 49.06  ? 74  LYS A NZ   1 
ATOM   1108 H H    . LYS A 1 110 ? 19.423  -2.898  -10.794 1.00 21.73  ? 74  LYS A H    1 
ATOM   1109 H HA   . LYS A 1 110 ? 17.373  -1.629  -9.755  1.00 21.84  ? 74  LYS A HA   1 
ATOM   1110 H HB2  . LYS A 1 110 ? 19.442  -0.598  -10.164 1.00 19.06  ? 74  LYS A HB2  1 
ATOM   1111 H HB3  . LYS A 1 110 ? 19.156  -0.678  -11.725 1.00 19.06  ? 74  LYS A HB3  1 
ATOM   1112 H HG2  . LYS A 1 110 ? 17.308  0.808   -11.318 1.00 24.18  ? 74  LYS A HG2  1 
ATOM   1113 H HG3  . LYS A 1 110 ? 17.947  1.051   -9.883  1.00 24.18  ? 74  LYS A HG3  1 
ATOM   1114 H HD2  . LYS A 1 110 ? 19.972  1.556   -11.204 1.00 36.10  ? 74  LYS A HD2  1 
ATOM   1115 H HD3  . LYS A 1 110 ? 18.911  1.871   -12.344 1.00 36.10  ? 74  LYS A HD3  1 
ATOM   1116 H HE2  . LYS A 1 110 ? 17.936  3.499   -11.037 1.00 50.48  ? 74  LYS A HE2  1 
ATOM   1117 H HE3  . LYS A 1 110 ? 18.896  3.135   -9.823  1.00 50.48  ? 74  LYS A HE3  1 
ATOM   1118 H HZ1  . LYS A 1 110 ? 19.700  4.957   -10.921 1.00 58.86  ? 74  LYS A HZ1  1 
ATOM   1119 H HZ2  . LYS A 1 110 ? 20.651  3.879   -11.098 1.00 58.86  ? 74  LYS A HZ2  1 
ATOM   1120 H HZ3  . LYS A 1 110 ? 19.759  4.242   -12.180 1.00 58.86  ? 74  LYS A HZ3  1 
ATOM   1121 N N    . HIS A 1 111 ? 17.054  -2.303  -12.860 1.00 19.07  ? 75  HIS A N    1 
ATOM   1122 C CA   . HIS A 1 111 ? 16.072  -2.372  -13.934 1.00 19.71  ? 75  HIS A CA   1 
ATOM   1123 C C    . HIS A 1 111 ? 14.898  -3.275  -13.563 1.00 18.06  ? 75  HIS A C    1 
ATOM   1124 O O    . HIS A 1 111 ? 13.735  -2.888  -13.712 1.00 17.79  ? 75  HIS A O    1 
ATOM   1125 C CB   . HIS A 1 111 ? 16.727  -2.879  -15.214 1.00 23.38  ? 75  HIS A CB   1 
ATOM   1126 C CG   . HIS A 1 111 ? 15.748  -3.122  -16.324 1.00 24.44  ? 75  HIS A CG   1 
ATOM   1127 N ND1  . HIS A 1 111 ? 15.424  -2.156  -17.260 1.00 24.64  ? 75  HIS A ND1  1 
ATOM   1128 C CD2  . HIS A 1 111 ? 15.017  -4.215  -16.646 1.00 26.01  ? 75  HIS A CD2  1 
ATOM   1129 C CE1  . HIS A 1 111 ? 14.520  -2.641  -18.092 1.00 27.69  ? 75  HIS A CE1  1 
ATOM   1130 N NE2  . HIS A 1 111 ? 14.261  -3.888  -17.748 1.00 24.59  ? 75  HIS A NE2  1 
ATOM   1131 H H    . HIS A 1 111 ? 17.833  -2.607  -13.064 1.00 22.88  ? 75  HIS A H    1 
ATOM   1132 H HA   . HIS A 1 111 ? 15.733  -1.476  -14.089 1.00 23.64  ? 75  HIS A HA   1 
ATOM   1133 H HB2  . HIS A 1 111 ? 17.368  -2.219  -15.522 1.00 28.04  ? 75  HIS A HB2  1 
ATOM   1134 H HB3  . HIS A 1 111 ? 17.178  -3.717  -15.026 1.00 28.04  ? 75  HIS A HB3  1 
ATOM   1135 H HD1  . HIS A 1 111 ? 15.758  -1.364  -17.294 1.00 29.56  ? 75  HIS A HD1  1 
ATOM   1136 H HD2  . HIS A 1 111 ? 15.024  -5.034  -16.205 1.00 31.21  ? 75  HIS A HD2  1 
ATOM   1137 H HE1  . HIS A 1 111 ? 14.133  -2.181  -18.801 1.00 33.21  ? 75  HIS A HE1  1 
ATOM   1138 N N    . GLU A 1 112 ? 15.177  -4.495  -13.095 1.00 21.14  ? 76  GLU A N    1 
ATOM   1139 C CA   . GLU A 1 112 ? 14.067  -5.404  -12.796 1.00 17.25  ? 76  GLU A CA   1 
ATOM   1140 C C    . GLU A 1 112 ? 13.268  -4.945  -11.584 1.00 18.15  ? 76  GLU A C    1 
ATOM   1141 O O    . GLU A 1 112 ? 12.031  -5.030  -11.586 1.00 17.71  ? 76  GLU A O    1 
ATOM   1142 C CB   . GLU A 1 112 ? 14.558  -6.843  -12.626 1.00 17.25  ? 76  GLU A CB   1 
ATOM   1143 C CG   . GLU A 1 112 ? 15.422  -7.356  -13.727 1.00 21.28  ? 76  GLU A CG   1 
ATOM   1144 C CD   . GLU A 1 112 ? 14.721  -7.443  -15.059 1.00 21.07  ? 76  GLU A CD   1 
ATOM   1145 O OE1  . GLU A 1 112 ? 13.524  -7.114  -15.138 1.00 21.57  ? 76  GLU A OE1  1 
ATOM   1146 O OE2  . GLU A 1 112 ? 15.372  -7.867  -16.021 1.00 19.94  ? 76  GLU A OE2  1 
ATOM   1147 H H    . GLU A 1 112 ? 15.965  -4.807  -12.948 1.00 25.35  ? 76  GLU A H    1 
ATOM   1148 H HA   . GLU A 1 112 ? 13.467  -5.400  -13.559 1.00 20.69  ? 76  GLU A HA   1 
ATOM   1149 H HB2  . GLU A 1 112 ? 15.073  -6.895  -11.806 1.00 20.69  ? 76  GLU A HB2  1 
ATOM   1150 H HB3  . GLU A 1 112 ? 13.785  -7.425  -12.570 1.00 20.69  ? 76  GLU A HB3  1 
ATOM   1151 H HG2  . GLU A 1 112 ? 16.182  -6.762  -13.831 1.00 25.53  ? 76  GLU A HG2  1 
ATOM   1152 H HG3  . GLU A 1 112 ? 15.728  -8.247  -13.495 1.00 25.53  ? 76  GLU A HG3  1 
ATOM   1153 N N    . ALA A 1 113 ? 13.924  -4.399  -10.561 1.00 20.37  ? 77  ALA A N    1 
ATOM   1154 C CA   . ALA A 1 113 ? 13.173  -3.892  -9.416  1.00 21.48  ? 77  ALA A CA   1 
ATOM   1155 C C    . ALA A 1 113 ? 12.105  -2.896  -9.860  1.00 22.81  ? 77  ALA A C    1 
ATOM   1156 O O    . ALA A 1 113 ? 10.936  -2.971  -9.441  1.00 21.48  ? 77  ALA A O    1 
ATOM   1157 C CB   . ALA A 1 113 ? 14.142  -3.254  -8.410  1.00 20.25  ? 77  ALA A CB   1 
ATOM   1158 H H    . ALA A 1 113 ? 14.778  -4.313  -10.507 1.00 24.44  ? 77  ALA A H    1 
ATOM   1159 H HA   . ALA A 1 113 ? 12.723  -4.627  -8.970  1.00 25.77  ? 77  ALA A HA   1 
ATOM   1160 H HB1  . ALA A 1 113 ? 13.635  -2.901  -7.663  1.00 24.29  ? 77  ALA A HB1  1 
ATOM   1161 H HB2  . ALA A 1 113 ? 14.764  -3.930  -8.097  1.00 24.29  ? 77  ALA A HB2  1 
ATOM   1162 H HB3  . ALA A 1 113 ? 14.627  -2.537  -8.849  1.00 24.29  ? 77  ALA A HB3  1 
ATOM   1163 N N    . ALA A 1 114 ? 12.480  -1.983  -10.750 1.00 22.34  ? 78  ALA A N    1 
ATOM   1164 C CA   . ALA A 1 114 ? 11.534  -0.985  -11.238 1.00 26.42  ? 78  ALA A CA   1 
ATOM   1165 C C    . ALA A 1 114 ? 10.461  -1.628  -12.101 1.00 23.80  ? 78  ALA A C    1 
ATOM   1166 O O    . ALA A 1 114 ? 9.266   -1.305  -11.961 1.00 22.90  ? 78  ALA A O    1 
ATOM   1167 C CB   . ALA A 1 114 ? 12.278  0.099   -12.009 1.00 25.91  ? 78  ALA A CB   1 
ATOM   1168 H H    . ALA A 1 114 ? 13.270  -1.919  -11.085 1.00 26.80  ? 78  ALA A H    1 
ATOM   1169 H HA   . ALA A 1 114 ? 11.095  -0.565  -10.482 1.00 31.69  ? 78  ALA A HA   1 
ATOM   1170 H HB1  . ALA A 1 114 ? 11.633  0.719   -12.385 1.00 31.08  ? 78  ALA A HB1  1 
ATOM   1171 H HB2  . ALA A 1 114 ? 12.871  0.568   -11.401 1.00 31.08  ? 78  ALA A HB2  1 
ATOM   1172 H HB3  . ALA A 1 114 ? 12.792  -0.315  -12.720 1.00 31.08  ? 78  ALA A HB3  1 
ATOM   1173 N N    . ALA A 1 115 ? 10.862  -2.569  -12.965 1.00 21.97  ? 79  ALA A N    1 
ATOM   1174 C CA   . ALA A 1 115 ? 9.900   -3.275  -13.810 1.00 26.32  ? 79  ALA A CA   1 
ATOM   1175 C C    . ALA A 1 115 ? 8.862   -3.993  -12.956 1.00 26.23  ? 79  ALA A C    1 
ATOM   1176 O O    . ALA A 1 115 ? 7.655   -3.892  -13.208 1.00 22.55  ? 79  ALA A O    1 
ATOM   1177 C CB   . ALA A 1 115 ? 10.626  -4.263  -14.738 1.00 25.14  ? 79  ALA A CB   1 
ATOM   1178 H H    . ALA A 1 115 ? 11.678  -2.814  -13.079 1.00 26.35  ? 79  ALA A H    1 
ATOM   1179 H HA   . ALA A 1 115 ? 9.441   -2.630  -14.371 1.00 31.57  ? 79  ALA A HA   1 
ATOM   1180 H HB1  . ALA A 1 115 ? 9.971   -4.716  -15.292 1.00 30.16  ? 79  ALA A HB1  1 
ATOM   1181 H HB2  . ALA A 1 115 ? 11.248  -3.771  -15.298 1.00 30.16  ? 79  ALA A HB2  1 
ATOM   1182 H HB3  . ALA A 1 115 ? 11.106  -4.909  -14.198 1.00 30.16  ? 79  ALA A HB3  1 
ATOM   1183 N N    . PHE A 1 116 ? 9.310   -4.709  -11.923 1.00 20.15  ? 80  PHE A N    1 
ATOM   1184 C CA   . PHE A 1 116 ? 8.357   -5.431  -11.081 1.00 22.68  ? 80  PHE A CA   1 
ATOM   1185 C C    . PHE A 1 116 ? 7.484   -4.488  -10.277 1.00 20.85  ? 80  PHE A C    1 
ATOM   1186 O O    . PHE A 1 116 ? 6.290   -4.738  -10.090 1.00 25.89  ? 80  PHE A O    1 
ATOM   1187 C CB   . PHE A 1 116 ? 9.096   -6.367  -10.146 1.00 21.08  ? 80  PHE A CB   1 
ATOM   1188 C CG   . PHE A 1 116 ? 9.445   -7.652  -10.775 1.00 20.88  ? 80  PHE A CG   1 
ATOM   1189 C CD1  . PHE A 1 116 ? 8.483   -8.619  -10.969 1.00 19.26  ? 80  PHE A CD1  1 
ATOM   1190 C CD2  . PHE A 1 116 ? 10.736  -7.891  -11.210 1.00 24.34  ? 80  PHE A CD2  1 
ATOM   1191 C CE1  . PHE A 1 116 ? 8.813   -9.839  -11.553 1.00 17.31  ? 80  PHE A CE1  1 
ATOM   1192 C CE2  . PHE A 1 116 ? 11.069  -9.077  -11.805 1.00 19.81  ? 80  PHE A CE2  1 
ATOM   1193 C CZ   . PHE A 1 116 ? 10.107  -10.060 -11.980 1.00 19.45  ? 80  PHE A CZ   1 
ATOM   1194 H H    . PHE A 1 116 ? 10.135  -4.790  -11.694 1.00 24.17  ? 80  PHE A H    1 
ATOM   1195 H HA   . PHE A 1 116 ? 7.782   -5.955  -11.660 1.00 27.21  ? 80  PHE A HA   1 
ATOM   1196 H HB2  . PHE A 1 116 ? 9.919   -5.941  -9.860  1.00 25.28  ? 80  PHE A HB2  1 
ATOM   1197 H HB3  . PHE A 1 116 ? 8.534   -6.553  -9.378  1.00 25.28  ? 80  PHE A HB3  1 
ATOM   1198 H HD1  . PHE A 1 116 ? 7.605   -8.456  -10.707 1.00 23.10  ? 80  PHE A HD1  1 
ATOM   1199 H HD2  . PHE A 1 116 ? 11.387  -7.237  -11.097 1.00 29.20  ? 80  PHE A HD2  1 
ATOM   1200 H HE1  . PHE A 1 116 ? 8.166   -10.499 -11.656 1.00 20.76  ? 80  PHE A HE1  1 
ATOM   1201 H HE2  . PHE A 1 116 ? 11.941  -9.224  -12.092 1.00 23.76  ? 80  PHE A HE2  1 
ATOM   1202 H HZ   . PHE A 1 116 ? 10.333  -10.867 -12.384 1.00 23.33  ? 80  PHE A HZ   1 
ATOM   1203 N N    . LYS A 1 117 ? 8.070   -3.431  -9.746  1.00 23.03  ? 81  LYS A N    1 
ATOM   1204 C CA   . LYS A 1 117 ? 7.276   -2.509  -8.957  1.00 24.08  ? 81  LYS A CA   1 
ATOM   1205 C C    . LYS A 1 117 ? 6.296   -1.702  -9.801  1.00 26.56  ? 81  LYS A C    1 
ATOM   1206 O O    . LYS A 1 117 ? 5.315   -1.202  -9.248  1.00 27.64  ? 81  LYS A O    1 
ATOM   1207 C CB   . LYS A 1 117 ? 8.183   -1.567  -8.183  1.00 28.87  ? 81  LYS A CB   1 
ATOM   1208 C CG   . LYS A 1 117 ? 8.868   -2.242  -7.020  1.00 25.27  ? 81  LYS A CG   1 
ATOM   1209 C CD   . LYS A 1 117 ? 10.059  -1.413  -6.526  1.00 25.76  ? 81  LYS A CD   1 
ATOM   1210 C CE   . LYS A 1 117 ? 10.793  -2.130  -5.438  1.00 26.96  ? 81  LYS A CE   1 
ATOM   1211 N NZ   . LYS A 1 117 ? 9.931   -2.317  -4.241  1.00 28.44  ? 81  LYS A NZ   1 
ATOM   1212 H H    . LYS A 1 117 ? 8.903   -3.229  -9.826  1.00 27.63  ? 81  LYS A H    1 
ATOM   1213 H HA   . LYS A 1 117 ? 6.760   -3.025  -8.318  1.00 28.88  ? 81  LYS A HA   1 
ATOM   1214 H HB2  . LYS A 1 117 ? 8.868   -1.228  -8.780  1.00 34.63  ? 81  LYS A HB2  1 
ATOM   1215 H HB3  . LYS A 1 117 ? 7.653   -0.834  -7.835  1.00 34.63  ? 81  LYS A HB3  1 
ATOM   1216 H HG2  . LYS A 1 117 ? 8.240   -2.342  -6.288  1.00 30.31  ? 81  LYS A HG2  1 
ATOM   1217 H HG3  . LYS A 1 117 ? 9.195   -3.112  -7.298  1.00 30.31  ? 81  LYS A HG3  1 
ATOM   1218 H HD2  . LYS A 1 117 ? 10.673  -1.258  -7.261  1.00 30.90  ? 81  LYS A HD2  1 
ATOM   1219 H HD3  . LYS A 1 117 ? 9.741   -0.566  -6.176  1.00 30.90  ? 81  LYS A HD3  1 
ATOM   1220 H HE2  . LYS A 1 117 ? 11.068  -3.004  -5.757  1.00 32.34  ? 81  LYS A HE2  1 
ATOM   1221 H HE3  . LYS A 1 117 ? 11.570  -1.612  -5.177  1.00 32.34  ? 81  LYS A HE3  1 
ATOM   1222 H HZ1  . LYS A 1 117 ? 10.313  -2.890  -3.677  1.00 34.11  ? 81  LYS A HZ1  1 
ATOM   1223 H HZ2  . LYS A 1 117 ? 9.812   -1.539  -3.826  1.00 34.11  ? 81  LYS A HZ2  1 
ATOM   1224 H HZ3  . LYS A 1 117 ? 9.137   -2.638  -4.485  1.00 34.11  ? 81  LYS A HZ3  1 
ATOM   1225 N N    . LYS A 1 118 ? 6.544   -1.541  -11.101 1.00 24.12  ? 82  LYS A N    1 
ATOM   1226 C CA   . LYS A 1 118 ? 5.520   -0.956  -11.974 1.00 27.88  ? 82  LYS A CA   1 
ATOM   1227 C C    . LYS A 1 118 ? 4.228   -1.764  -11.909 1.00 32.61  ? 82  LYS A C    1 
ATOM   1228 O O    . LYS A 1 118 ? 3.130   -1.203  -11.841 1.00 32.66  ? 82  LYS A O    1 
ATOM   1229 C CB   . LYS A 1 118 ? 6.019   -0.889  -13.412 1.00 27.33  ? 82  LYS A CB   1 
ATOM   1230 H H    . LYS A 1 118 ? 7.278   -1.755  -11.496 1.00 28.93  ? 82  LYS A H    1 
ATOM   1231 H HA   . LYS A 1 118 ? 5.339   -0.051  -11.676 1.00 33.45  ? 82  LYS A HA   1 
ATOM   1232 N N    . ILE A 1 119 ? 4.346   -3.084  -11.939 1.00 25.79  ? 83  ILE A N    1 
ATOM   1233 C CA   . ILE A 1 119 ? 3.186   -3.968  -11.817 1.00 33.00  ? 83  ILE A CA   1 
ATOM   1234 C C    . ILE A 1 119 ? 2.679   -4.038  -10.377 1.00 34.27  ? 83  ILE A C    1 
ATOM   1235 O O    . ILE A 1 119 ? 1.513   -3.734  -10.102 1.00 34.03  ? 83  ILE A O    1 
ATOM   1236 C CB   . ILE A 1 119 ? 3.540   -5.372  -12.332 1.00 34.30  ? 83  ILE A CB   1 
ATOM   1237 C CG1  . ILE A 1 119 ? 4.021   -5.279  -13.768 1.00 34.70  ? 83  ILE A CG1  1 
ATOM   1238 C CG2  . ILE A 1 119 ? 2.334   -6.321  -12.183 1.00 32.96  ? 83  ILE A CG2  1 
ATOM   1239 C CD1  . ILE A 1 119 ? 4.379   -6.631  -14.346 1.00 40.81  ? 83  ILE A CD1  1 
ATOM   1240 H H    . ILE A 1 119 ? 5.092   -3.503  -12.031 1.00 30.94  ? 83  ILE A H    1 
ATOM   1241 H HA   . ILE A 1 119 ? 2.474   -3.597  -12.361 1.00 39.59  ? 83  ILE A HA   1 
ATOM   1242 H HB   . ILE A 1 119 ? 4.260   -5.741  -11.798 1.00 41.15  ? 83  ILE A HB   1 
ATOM   1243 H HG12 . ILE A 1 119 ? 3.317   -4.895  -14.314 1.00 41.63  ? 83  ILE A HG12 1 
ATOM   1244 H HG13 . ILE A 1 119 ? 4.811   -4.718  -13.802 1.00 41.63  ? 83  ILE A HG13 1 
ATOM   1245 H HG21 . ILE A 1 119 ? 2.579   -7.198  -12.516 1.00 39.54  ? 83  ILE A HG21 1 
ATOM   1246 H HG22 . ILE A 1 119 ? 2.092   -6.379  -11.245 1.00 39.54  ? 83  ILE A HG22 1 
ATOM   1247 H HG23 . ILE A 1 119 ? 1.590   -5.969  -12.695 1.00 39.54  ? 83  ILE A HG23 1 
ATOM   1248 H HD11 . ILE A 1 119 ? 4.936   -6.501  -15.129 1.00 48.96  ? 83  ILE A HD11 1 
ATOM   1249 H HD12 . ILE A 1 119 ? 4.862   -7.142  -13.678 1.00 48.96  ? 83  ILE A HD12 1 
ATOM   1250 H HD13 . ILE A 1 119 ? 3.564   -7.095  -14.592 1.00 48.96  ? 83  ILE A HD13 1 
ATOM   1251 N N    . LYS A 1 120 ? 3.506   -4.541  -9.451  1.00 28.75  ? 84  LYS A N    1 
ATOM   1252 C CA   . LYS A 1 120 ? 3.105   -4.646  -8.047  1.00 30.07  ? 84  LYS A CA   1 
ATOM   1253 C C    . LYS A 1 120 ? 3.951   -3.686  -7.248  1.00 34.26  ? 84  LYS A C    1 
ATOM   1254 O O    . LYS A 1 120 ? 5.090   -4.020  -6.877  1.00 26.76  ? 84  LYS A O    1 
ATOM   1255 C CB   . LYS A 1 120 ? 3.260   -6.063  -7.476  1.00 34.20  ? 84  LYS A CB   1 
ATOM   1256 C CG   . LYS A 1 120 ? 2.699   -7.164  -8.321  1.00 36.37  ? 84  LYS A CG   1 
ATOM   1257 C CD   . LYS A 1 120 ? 3.075   -8.545  -7.771  1.00 33.32  ? 84  LYS A CD   1 
ATOM   1258 C CE   . LYS A 1 120 ? 1.937   -9.181  -7.046  1.00 35.71  ? 84  LYS A CE   1 
ATOM   1259 N NZ   . LYS A 1 120 ? 2.148   -10.632 -6.787  1.00 26.47  ? 84  LYS A NZ   1 
ATOM   1260 H H    . LYS A 1 120 ? 4.301   -4.827  -9.614  1.00 34.49  ? 84  LYS A H    1 
ATOM   1261 H HA   . LYS A 1 120 ? 2.164   -4.420  -7.985  1.00 36.08  ? 84  LYS A HA   1 
ATOM   1262 H HB2  . LYS A 1 120 ? 4.206   -6.243  -7.358  1.00 41.02  ? 84  LYS A HB2  1 
ATOM   1263 H HB3  . LYS A 1 120 ? 2.807   -6.098  -6.619  1.00 41.02  ? 84  LYS A HB3  1 
ATOM   1264 H HG2  . LYS A 1 120 ? 1.732   -7.095  -8.336  1.00 43.64  ? 84  LYS A HG2  1 
ATOM   1265 H HG3  . LYS A 1 120 ? 3.051   -7.088  -9.222  1.00 43.64  ? 84  LYS A HG3  1 
ATOM   1266 H HD2  . LYS A 1 120 ? 3.329   -9.124  -8.507  1.00 39.97  ? 84  LYS A HD2  1 
ATOM   1267 H HD3  . LYS A 1 120 ? 3.816   -8.452  -7.152  1.00 39.97  ? 84  LYS A HD3  1 
ATOM   1268 H HE2  . LYS A 1 120 ? 1.822   -8.739  -6.190  1.00 42.84  ? 84  LYS A HE2  1 
ATOM   1269 H HE3  . LYS A 1 120 ? 1.132   -9.087  -7.579  1.00 42.84  ? 84  LYS A HE3  1 
ATOM   1270 H HZ1  . LYS A 1 120 ? 1.476   -10.956 -6.302  1.00 31.75  ? 84  LYS A HZ1  1 
ATOM   1271 H HZ2  . LYS A 1 120 ? 2.189   -11.076 -7.557  1.00 31.75  ? 84  LYS A HZ2  1 
ATOM   1272 H HZ3  . LYS A 1 120 ? 2.910   -10.754 -6.342  1.00 31.75  ? 84  LYS A HZ3  1 
ATOM   1273 N N    . PRO A 1 121 ? 3.455   -2.492  -6.943  1.00 27.40  ? 85  PRO A N    1 
ATOM   1274 C CA   . PRO A 1 121 ? 4.285   -1.536  -6.207  1.00 34.70  ? 85  PRO A CA   1 
ATOM   1275 C C    . PRO A 1 121 ? 4.762   -2.071  -4.870  1.00 32.78  ? 85  PRO A C    1 
ATOM   1276 O O    . PRO A 1 121 ? 5.774   -1.595  -4.357  1.00 34.23  ? 85  PRO A O    1 
ATOM   1277 C CB   . PRO A 1 121 ? 3.357   -0.322  -6.041  1.00 38.65  ? 85  PRO A CB   1 
ATOM   1278 C CG   . PRO A 1 121 ? 2.341   -0.474  -7.131  1.00 37.13  ? 85  PRO A CG   1 
ATOM   1279 C CD   . PRO A 1 121 ? 2.126   -1.943  -7.272  1.00 32.23  ? 85  PRO A CD   1 
ATOM   1280 H HA   . PRO A 1 121 ? 5.053   -1.272  -6.737  1.00 41.63  ? 85  PRO A HA   1 
ATOM   1281 H HB2  . PRO A 1 121 ? 2.937   -0.342  -5.167  1.00 46.37  ? 85  PRO A HB2  1 
ATOM   1282 H HB3  . PRO A 1 121 ? 3.863   0.499   -6.148  1.00 46.37  ? 85  PRO A HB3  1 
ATOM   1283 H HG2  . PRO A 1 121 ? 1.518   -0.027  -6.878  1.00 44.55  ? 85  PRO A HG2  1 
ATOM   1284 H HG3  . PRO A 1 121 ? 2.684   -0.096  -7.956  1.00 44.55  ? 85  PRO A HG3  1 
ATOM   1285 H HD2  . PRO A 1 121 ? 1.454   -2.258  -6.647  1.00 38.67  ? 85  PRO A HD2  1 
ATOM   1286 H HD3  . PRO A 1 121 ? 1.868   -2.172  -8.178  1.00 38.67  ? 85  PRO A HD3  1 
ATOM   1287 N N    . ASP A 1 122 ? 4.093   -3.064  -4.312  1.00 35.71  ? 86  ASP A N    1 
ATOM   1288 C CA   . ASP A 1 122 ? 4.435   -3.592  -2.999  1.00 46.79  ? 86  ASP A CA   1 
ATOM   1289 C C    . ASP A 1 122 ? 5.341   -4.816  -3.074  1.00 33.82  ? 86  ASP A C    1 
ATOM   1290 O O    . ASP A 1 122 ? 5.729   -5.340  -2.025  1.00 37.20  ? 86  ASP A O    1 
ATOM   1291 C CB   . ASP A 1 122 ? 3.153   -3.940  -2.231  1.00 58.07  ? 86  ASP A CB   1 
ATOM   1292 C CG   . ASP A 1 122 ? 2.243   -2.736  -2.041  1.00 63.18  ? 86  ASP A CG   1 
ATOM   1293 O OD1  . ASP A 1 122 ? 2.490   -1.934  -1.112  1.00 52.95  ? 86  ASP A OD1  1 
ATOM   1294 O OD2  . ASP A 1 122 ? 1.281   -2.594  -2.829  1.00 63.63  ? 86  ASP A OD2  1 
ATOM   1295 H H    . ASP A 1 122 ? 3.423   -3.459  -4.679  1.00 42.84  ? 86  ASP A H    1 
ATOM   1296 H HA   . ASP A 1 122 ? 4.907   -2.909  -2.498  1.00 56.13  ? 86  ASP A HA   1 
ATOM   1297 H HB2  . ASP A 1 122 ? 2.660   -4.615  -2.724  1.00 69.68  ? 86  ASP A HB2  1 
ATOM   1298 H HB3  . ASP A 1 122 ? 3.391   -4.279  -1.353  1.00 69.68  ? 86  ASP A HB3  1 
ATOM   1299 N N    . MET A 1 123 ? 5.647   -5.301  -4.280  1.00 29.34  ? 87  MET A N    1 
ATOM   1300 C CA   . MET A 1 123 ? 6.562   -6.431  -4.436  1.00 28.60  ? 87  MET A CA   1 
ATOM   1301 C C    . MET A 1 123 ? 7.848   -6.130  -3.675  1.00 26.95  ? 87  MET A C    1 
ATOM   1302 O O    . MET A 1 123 ? 8.320   -4.989  -3.656  1.00 22.20  ? 87  MET A O    1 
ATOM   1303 C CB   . MET A 1 123 ? 6.871   -6.669  -5.919  1.00 22.75  ? 87  MET A CB   1 
ATOM   1304 C CG   . MET A 1 123 ? 8.036   -7.633  -6.206  1.00 27.49  ? 87  MET A CG   1 
ATOM   1305 S SD   . MET A 1 123 ? 7.330   -9.306  -6.331  1.00 30.93  ? 87  MET A SD   1 
ATOM   1306 C CE   . MET A 1 123 ? 6.643   -9.261  -7.958  1.00 30.04  ? 87  MET A CE   1 
ATOM   1307 H H    . MET A 1 123 ? 5.339   -4.993  -5.022  1.00 35.20  ? 87  MET A H    1 
ATOM   1308 H HA   . MET A 1 123 ? 6.151   -7.241  -4.095  1.00 34.31  ? 87  MET A HA   1 
ATOM   1309 H HB2  . MET A 1 123 ? 6.079   -7.040  -6.339  1.00 27.29  ? 87  MET A HB2  1 
ATOM   1310 H HB3  . MET A 1 123 ? 7.095   -5.817  -6.324  1.00 27.29  ? 87  MET A HB3  1 
ATOM   1311 H HG2  . MET A 1 123 ? 8.468   -7.401  -7.043  1.00 32.98  ? 87  MET A HG2  1 
ATOM   1312 H HG3  . MET A 1 123 ? 8.681   -7.608  -5.482  1.00 32.98  ? 87  MET A HG3  1 
ATOM   1313 H HE1  . MET A 1 123 ? 6.222   -10.114 -8.147  1.00 36.04  ? 87  MET A HE1  1 
ATOM   1314 H HE2  . MET A 1 123 ? 5.984   -8.550  -8.003  1.00 36.04  ? 87  MET A HE2  1 
ATOM   1315 H HE3  . MET A 1 123 ? 7.353   -9.094  -8.597  1.00 36.04  ? 87  MET A HE3  1 
ATOM   1316 N N    . LYS A 1 124 ? 8.422   -7.144  -3.038  1.00 19.63  ? 88  LYS A N    1 
ATOM   1317 C CA   . LYS A 1 124 ? 9.714   -6.973  -2.405  1.00 16.29  ? 88  LYS A CA   1 
ATOM   1318 C C    . LYS A 1 124 ? 10.771  -7.590  -3.302  1.00 15.51  ? 88  LYS A C    1 
ATOM   1319 O O    . LYS A 1 124 ? 10.687  -8.765  -3.646  1.00 17.46  ? 88  LYS A O    1 
ATOM   1320 C CB   . LYS A 1 124 ? 9.801   -7.599  -1.022  1.00 20.53  ? 88  LYS A CB   1 
ATOM   1321 C CG   . LYS A 1 124 ? 8.826   -7.032  -0.004  1.00 18.06  ? 88  LYS A CG   1 
ATOM   1322 C CD   . LYS A 1 124 ? 9.033   -5.551  0.215   1.00 21.37  ? 88  LYS A CD   1 
ATOM   1323 C CE   . LYS A 1 124 ? 8.122   -4.965  1.309   1.00 24.15  ? 88  LYS A CE   1 
ATOM   1324 N NZ   . LYS A 1 124 ? 8.670   -3.679  1.840   1.00 27.58  ? 88  LYS A NZ   1 
ATOM   1325 H H    . LYS A 1 124 ? 8.083   -7.931  -2.963  1.00 23.55  ? 88  LYS A H    1 
ATOM   1326 H HA   . LYS A 1 124 ? 9.870   -6.023  -2.289  1.00 19.54  ? 88  LYS A HA   1 
ATOM   1327 H HB2  . LYS A 1 124 ? 9.620   -8.549  -1.102  1.00 24.63  ? 88  LYS A HB2  1 
ATOM   1328 H HB3  . LYS A 1 124 ? 10.697  -7.461  -0.677  1.00 24.63  ? 88  LYS A HB3  1 
ATOM   1329 H HG2  . LYS A 1 124 ? 7.920   -7.168  -0.321  1.00 21.67  ? 88  LYS A HG2  1 
ATOM   1330 H HG3  . LYS A 1 124 ? 8.952   -7.484  0.845   1.00 21.67  ? 88  LYS A HG3  1 
ATOM   1331 H HD2  . LYS A 1 124 ? 9.953   -5.398  0.481   1.00 25.63  ? 88  LYS A HD2  1 
ATOM   1332 H HD3  . LYS A 1 124 ? 8.844   -5.081  -0.612  1.00 25.63  ? 88  LYS A HD3  1 
ATOM   1333 H HE2  . LYS A 1 124 ? 7.242   -4.793  0.938   1.00 28.97  ? 88  LYS A HE2  1 
ATOM   1334 H HE3  . LYS A 1 124 ? 8.055   -5.595  2.044   1.00 28.97  ? 88  LYS A HE3  1 
ATOM   1335 H HZ1  . LYS A 1 124 ? 8.127   -3.351  2.464   1.00 33.08  ? 88  LYS A HZ1  1 
ATOM   1336 H HZ2  . LYS A 1 124 ? 9.473   -3.815  2.198   1.00 33.08  ? 88  LYS A HZ2  1 
ATOM   1337 H HZ3  . LYS A 1 124 ? 8.744   -3.085  1.181   1.00 33.08  ? 88  LYS A HZ3  1 
ATOM   1338 N N    . VAL A 1 125 ? 11.786  -6.796  -3.637  1.00 16.47  ? 89  VAL A N    1 
ATOM   1339 C CA   . VAL A 1 125 ? 12.853  -7.204  -4.533  1.00 16.72  ? 89  VAL A CA   1 
ATOM   1340 C C    . VAL A 1 125 ? 14.184  -7.024  -3.811  1.00 15.08  ? 89  VAL A C    1 
ATOM   1341 O O    . VAL A 1 125 ? 14.534  -5.911  -3.424  1.00 17.91  ? 89  VAL A O    1 
ATOM   1342 C CB   . VAL A 1 125 ? 12.847  -6.411  -5.844  1.00 16.54  ? 89  VAL A CB   1 
ATOM   1343 C CG1  . VAL A 1 125 ? 14.020  -6.857  -6.717  1.00 20.85  ? 89  VAL A CG1  1 
ATOM   1344 C CG2  . VAL A 1 125 ? 11.526  -6.608  -6.559  1.00 18.91  ? 89  VAL A CG2  1 
ATOM   1345 H H    . VAL A 1 125 ? 11.877  -5.992  -3.346  1.00 19.76  ? 89  VAL A H    1 
ATOM   1346 H HA   . VAL A 1 125 ? 12.738  -8.144  -4.739  1.00 20.06  ? 89  VAL A HA   1 
ATOM   1347 H HB   . VAL A 1 125 ? 12.949  -5.463  -5.662  1.00 19.83  ? 89  VAL A HB   1 
ATOM   1348 H HG11 . VAL A 1 125 ? 13.839  -6.613  -7.638  1.00 25.01  ? 89  VAL A HG11 1 
ATOM   1349 H HG12 . VAL A 1 125 ? 14.828  -6.416  -6.411  1.00 25.01  ? 89  VAL A HG12 1 
ATOM   1350 H HG13 . VAL A 1 125 ? 14.120  -7.819  -6.643  1.00 25.01  ? 89  VAL A HG13 1 
ATOM   1351 H HG21 . VAL A 1 125 ? 11.536  -6.102  -7.386  1.00 22.68  ? 89  VAL A HG21 1 
ATOM   1352 H HG22 . VAL A 1 125 ? 11.408  -7.552  -6.750  1.00 22.68  ? 89  VAL A HG22 1 
ATOM   1353 H HG23 . VAL A 1 125 ? 10.808  -6.295  -5.987  1.00 22.68  ? 89  VAL A HG23 1 
ATOM   1354 N N    . LEU A 1 126 ? 14.932  -8.117  -3.651  1.00 15.61  ? 90  LEU A N    1 
ATOM   1355 C CA   . LEU A 1 126 ? 16.223  -8.078  -2.970  1.00 15.09  ? 90  LEU A CA   1 
ATOM   1356 C C    . LEU A 1 126 ? 17.389  -7.970  -3.943  1.00 15.93  ? 90  LEU A C    1 
ATOM   1357 O O    . LEU A 1 126 ? 17.373  -8.538  -5.044  1.00 16.55  ? 90  LEU A O    1 
ATOM   1358 C CB   . LEU A 1 126 ? 16.456  -9.334  -2.108  1.00 16.56  ? 90  LEU A CB   1 
ATOM   1359 C CG   . LEU A 1 126 ? 15.370  -9.669  -1.071  1.00 17.47  ? 90  LEU A CG   1 
ATOM   1360 C CD1  . LEU A 1 126 ? 15.752  -10.905 -0.325  1.00 17.72  ? 90  LEU A CD1  1 
ATOM   1361 C CD2  . LEU A 1 126 ? 15.124  -8.474  -0.140  1.00 19.32  ? 90  LEU A CD2  1 
ATOM   1362 H H    . LEU A 1 126 ? 14.709  -8.898  -3.932  1.00 18.72  ? 90  LEU A H    1 
ATOM   1363 H HA   . LEU A 1 126 ? 16.211  -7.287  -2.409  1.00 18.10  ? 90  LEU A HA   1 
ATOM   1364 H HB2  . LEU A 1 126 ? 16.526  -10.097 -2.703  1.00 19.86  ? 90  LEU A HB2  1 
ATOM   1365 H HB3  . LEU A 1 126 ? 17.287  -9.214  -1.622  1.00 19.86  ? 90  LEU A HB3  1 
ATOM   1366 H HG   . LEU A 1 126 ? 14.526  -9.847  -1.515  1.00 20.95  ? 90  LEU A HG   1 
ATOM   1367 H HD11 . LEU A 1 126 ? 15.072  -11.096 0.340   1.00 21.26  ? 90  LEU A HD11 1 
ATOM   1368 H HD12 . LEU A 1 126 ? 15.819  -11.643 -0.950  1.00 21.26  ? 90  LEU A HD12 1 
ATOM   1369 H HD13 . LEU A 1 126 ? 16.608  -10.760 0.109   1.00 21.26  ? 90  LEU A HD13 1 
ATOM   1370 H HD21 . LEU A 1 126 ? 14.462  -8.723  0.525   1.00 23.17  ? 90  LEU A HD21 1 
ATOM   1371 H HD22 . LEU A 1 126 ? 15.957  -8.237  0.296   1.00 23.17  ? 90  LEU A HD22 1 
ATOM   1372 H HD23 . LEU A 1 126 ? 14.800  -7.726  -0.665  1.00 23.17  ? 90  LEU A HD23 1 
ATOM   1373 N N    . PHE A 1 127 ? 18.380  -7.215  -3.524  1.00 14.27  ? 91  PHE A N    1 
ATOM   1374 C CA   . PHE A 1 127 ? 19.676  -7.122  -4.173  1.00 12.54  ? 91  PHE A CA   1 
ATOM   1375 C C    . PHE A 1 127 ? 20.584  -8.216  -3.631  1.00 15.49  ? 91  PHE A C    1 
ATOM   1376 O O    . PHE A 1 127 ? 20.671  -8.429  -2.412  1.00 13.23  ? 91  PHE A O    1 
ATOM   1377 C CB   . PHE A 1 127 ? 20.236  -5.726  -3.913  1.00 12.81  ? 91  PHE A CB   1 
ATOM   1378 C CG   . PHE A 1 127 ? 21.676  -5.520  -4.319  1.00 11.21  ? 91  PHE A CG   1 
ATOM   1379 C CD1  . PHE A 1 127 ? 22.035  -5.390  -5.648  1.00 12.51  ? 91  PHE A CD1  1 
ATOM   1380 C CD2  . PHE A 1 127 ? 22.646  -5.421  -3.365  1.00 15.23  ? 91  PHE A CD2  1 
ATOM   1381 C CE1  . PHE A 1 127 ? 23.363  -5.168  -6.000  1.00 15.93  ? 91  PHE A CE1  1 
ATOM   1382 C CE2  . PHE A 1 127 ? 23.966  -5.217  -3.711  1.00 16.26  ? 91  PHE A CE2  1 
ATOM   1383 C CZ   . PHE A 1 127 ? 24.307  -5.094  -5.033  1.00 19.86  ? 91  PHE A CZ   1 
ATOM   1384 H H    . PHE A 1 127 ? 18.328  -6.716  -2.825  1.00 17.11  ? 91  PHE A H    1 
ATOM   1385 H HA   . PHE A 1 127 ? 19.617  -7.256  -5.132  1.00 15.03  ? 91  PHE A HA   1 
ATOM   1386 H HB2  . PHE A 1 127 ? 19.702  -5.085  -4.409  1.00 15.36  ? 91  PHE A HB2  1 
ATOM   1387 H HB3  . PHE A 1 127 ? 20.174  -5.544  -2.962  1.00 15.36  ? 91  PHE A HB3  1 
ATOM   1388 H HD1  . PHE A 1 127 ? 21.385  -5.450  -6.310  1.00 15.01  ? 91  PHE A HD1  1 
ATOM   1389 H HD2  . PHE A 1 127 ? 22.414  -5.493  -2.467  1.00 18.27  ? 91  PHE A HD2  1 
ATOM   1390 H HE1  . PHE A 1 127 ? 23.601  -5.073  -6.894  1.00 19.11  ? 91  PHE A HE1  1 
ATOM   1391 H HE2  . PHE A 1 127 ? 24.620  -5.164  -3.052  1.00 19.51  ? 91  PHE A HE2  1 
ATOM   1392 H HZ   . PHE A 1 127 ? 25.196  -4.957  -5.267  1.00 23.82  ? 91  PHE A HZ   1 
ATOM   1393 N N    . TYR A 1 128 ? 21.261  -8.895  -4.534  1.00 11.97  ? 92  TYR A N    1 
ATOM   1394 C CA   . TYR A 1 128 ? 22.146  -9.990  -4.168  1.00 13.06  ? 92  TYR A CA   1 
ATOM   1395 C C    . TYR A 1 128 ? 23.546  -9.475  -3.901  1.00 14.00  ? 92  TYR A C    1 
ATOM   1396 O O    . TYR A 1 128 ? 24.092  -8.708  -4.698  1.00 17.50  ? 92  TYR A O    1 
ATOM   1397 C CB   . TYR A 1 128 ? 22.207  -11.003 -5.297  1.00 14.48  ? 92  TYR A CB   1 
ATOM   1398 C CG   . TYR A 1 128 ? 23.195  -12.123 -5.090  1.00 14.52  ? 92  TYR A CG   1 
ATOM   1399 C CD1  . TYR A 1 128 ? 24.542  -11.922 -5.284  1.00 13.47  ? 92  TYR A CD1  1 
ATOM   1400 C CD2  . TYR A 1 128 ? 22.779  -13.383 -4.731  1.00 14.52  ? 92  TYR A CD2  1 
ATOM   1401 C CE1  . TYR A 1 128 ? 25.436  -12.947 -5.126  1.00 13.38  ? 92  TYR A CE1  1 
ATOM   1402 C CE2  . TYR A 1 128 ? 23.686  -14.415 -4.569  1.00 17.14  ? 92  TYR A CE2  1 
ATOM   1403 C CZ   . TYR A 1 128 ? 25.017  -14.156 -4.747  1.00 15.35  ? 92  TYR A CZ   1 
ATOM   1404 O OH   . TYR A 1 128 ? 25.980  -15.120 -4.625  1.00 18.87  ? 92  TYR A OH   1 
ATOM   1405 H H    . TYR A 1 128 ? 21.228  -8.741  -5.379  1.00 14.36  ? 92  TYR A H    1 
ATOM   1406 H HA   . TYR A 1 128 ? 21.808  -10.411 -3.362  1.00 15.67  ? 92  TYR A HA   1 
ATOM   1407 H HB2  . TYR A 1 128 ? 21.330  -11.404 -5.400  1.00 17.37  ? 92  TYR A HB2  1 
ATOM   1408 H HB3  . TYR A 1 128 ? 22.458  -10.541 -6.112  1.00 17.37  ? 92  TYR A HB3  1 
ATOM   1409 H HD1  . TYR A 1 128 ? 24.849  -11.079 -5.526  1.00 16.15  ? 92  TYR A HD1  1 
ATOM   1410 H HD2  . TYR A 1 128 ? 21.873  -13.544 -4.594  1.00 17.42  ? 92  TYR A HD2  1 
ATOM   1411 H HE1  . TYR A 1 128 ? 26.341  -12.800 -5.284  1.00 16.05  ? 92  TYR A HE1  1 
ATOM   1412 H HE2  . TYR A 1 128 ? 23.396  -15.269 -4.344  1.00 20.56  ? 92  TYR A HE2  1 
ATOM   1413 H HH   . TYR A 1 128 ? 25.640  -15.830 -4.331  1.00 22.63  ? 92  TYR A HH   1 
ATOM   1414 N N    . PHE A 1 129 ? 24.152  -9.937  -2.822  1.00 13.29  ? 93  PHE A N    1 
ATOM   1415 C CA   . PHE A 1 129 ? 25.596  -9.739  -2.719  1.00 13.95  ? 93  PHE A CA   1 
ATOM   1416 C C    . PHE A 1 129 ? 26.228  -10.882 -1.943  1.00 16.26  ? 93  PHE A C    1 
ATOM   1417 O O    . PHE A 1 129 ? 25.731  -11.306 -0.904  1.00 17.46  ? 93  PHE A O    1 
ATOM   1418 C CB   . PHE A 1 129 ? 25.920  -8.388  -2.102  1.00 15.01  ? 93  PHE A CB   1 
ATOM   1419 C CG   . PHE A 1 129 ? 27.193  -7.772  -2.640  1.00 13.39  ? 93  PHE A CG   1 
ATOM   1420 C CD1  . PHE A 1 129 ? 27.257  -7.292  -3.928  1.00 15.87  ? 93  PHE A CD1  1 
ATOM   1421 C CD2  . PHE A 1 129 ? 28.331  -7.740  -1.863  1.00 19.20  ? 93  PHE A CD2  1 
ATOM   1422 C CE1  . PHE A 1 129 ? 28.448  -6.711  -4.412  1.00 17.48  ? 93  PHE A CE1  1 
ATOM   1423 C CE2  . PHE A 1 129 ? 29.496  -7.208  -2.355  1.00 19.20  ? 93  PHE A CE2  1 
ATOM   1424 C CZ   . PHE A 1 129 ? 29.534  -6.699  -3.643  1.00 17.19  ? 93  PHE A CZ   1 
ATOM   1425 H H    . PHE A 1 129 ? 23.774  -10.346 -2.167  1.00 15.93  ? 93  PHE A H    1 
ATOM   1426 H HA   . PHE A 1 129 ? 25.993  -9.764  -3.604  1.00 16.73  ? 93  PHE A HA   1 
ATOM   1427 H HB2  . PHE A 1 129 ? 25.191  -7.776  -2.289  1.00 18.00  ? 93  PHE A HB2  1 
ATOM   1428 H HB3  . PHE A 1 129 ? 26.024  -8.498  -1.144  1.00 18.00  ? 93  PHE A HB3  1 
ATOM   1429 H HD1  . PHE A 1 129 ? 26.513  -7.351  -4.482  1.00 19.03  ? 93  PHE A HD1  1 
ATOM   1430 H HD2  . PHE A 1 129 ? 28.310  -8.081  -0.998  1.00 23.03  ? 93  PHE A HD2  1 
ATOM   1431 H HE1  . PHE A 1 129 ? 28.474  -6.338  -5.264  1.00 20.96  ? 93  PHE A HE1  1 
ATOM   1432 H HE2  . PHE A 1 129 ? 30.260  -7.189  -1.825  1.00 23.03  ? 93  PHE A HE2  1 
ATOM   1433 H HZ   . PHE A 1 129 ? 30.327  -6.345  -3.975  1.00 20.62  ? 93  PHE A HZ   1 
ATOM   1434 N N    . ASN A 1 130 ? 27.350  -11.380 -2.452  1.00 15.98  ? 94  ASN A N    1 
ATOM   1435 C CA   . ASN A 1 130 ? 28.048  -12.472 -1.819  1.00 17.26  ? 94  ASN A CA   1 
ATOM   1436 C C    . ASN A 1 130 ? 29.023  -11.961 -0.767  1.00 19.34  ? 94  ASN A C    1 
ATOM   1437 O O    . ASN A 1 130 ? 29.728  -11.014 -1.007  1.00 15.79  ? 94  ASN A O    1 
ATOM   1438 C CB   . ASN A 1 130 ? 28.794  -13.243 -2.883  1.00 17.37  ? 94  ASN A CB   1 
ATOM   1439 C CG   . ASN A 1 130 ? 29.119  -14.660 -2.468  1.00 17.95  ? 94  ASN A CG   1 
ATOM   1440 O OD1  . ASN A 1 130 ? 29.939  -14.888 -1.601  1.00 19.75  ? 94  ASN A OD1  1 
ATOM   1441 N ND2  . ASN A 1 130 ? 28.485  -15.619 -3.116  1.00 21.73  ? 94  ASN A ND2  1 
ATOM   1442 H H    . ASN A 1 130 ? 27.738  -11.104 -3.170  1.00 19.17  ? 94  ASN A H    1 
ATOM   1443 H HA   . ASN A 1 130 ? 27.413  -13.084 -1.391  1.00 20.71  ? 94  ASN A HA   1 
ATOM   1444 H HB2  . ASN A 1 130 ? 28.245  -13.288 -3.683  1.00 20.83  ? 94  ASN A HB2  1 
ATOM   1445 H HB3  . ASN A 1 130 ? 29.629  -12.791 -3.075  1.00 20.83  ? 94  ASN A HB3  1 
ATOM   1446 H HD21 . ASN A 1 130 ? 28.967  -16.424 -3.397  1.00 26.07  ? 94  ASN A HD21 1 
ATOM   1447 H HD22 . ASN A 1 130 ? 27.533  -15.520 -3.323  1.00 26.07  ? 94  ASN A HD22 1 
ATOM   1448 N N    . SER A 1 131 ? 29.025  -12.608 0.394   1.00 17.92  ? 95  SER A N    1 
ATOM   1449 C CA   . SER A 1 131 ? 29.863  -12.184 1.487   1.00 14.93  ? 95  SER A CA   1 
ATOM   1450 C C    . SER A 1 131 ? 31.238  -12.743 1.405   1.00 19.07  ? 95  SER A C    1 
ATOM   1451 O O    . SER A 1 131 ? 32.092  -12.320 2.141   1.00 18.22  ? 95  SER A O    1 
ATOM   1452 C CB   . SER A 1 131 ? 29.290  -12.738 2.793   1.00 15.99  ? 95  SER A CB   1 
ATOM   1453 O OG   . SER A 1 131 ? 29.406  -14.129 2.830   1.00 18.07  ? 95  SER A OG   1 
ATOM   1454 H H    . SER A 1 131 ? 28.544  -13.300 0.567   1.00 21.49  ? 95  SER A H    1 
ATOM   1455 H HA   . SER A 1 131 ? 29.906  -11.209 1.536   1.00 17.90  ? 95  SER A HA   1 
ATOM   1456 H HB2  . SER A 1 131 ? 29.775  -12.354 3.540   1.00 19.18  ? 95  SER A HB2  1 
ATOM   1457 H HB3  . SER A 1 131 ? 28.351  -12.495 2.845   1.00 19.18  ? 95  SER A HB3  1 
ATOM   1458 H HG   . SER A 1 131 ? 28.960  -14.432 3.448   1.00 21.67  ? 95  SER A HG   1 
ATOM   1459 N N    . ALA A 1 132 ? 31.433  -13.695 0.511   1.00 15.41  ? 96  ALA A N    1 
ATOM   1460 C CA   . ALA A 1 132 ? 32.701  -14.405 0.429   1.00 16.21  ? 96  ALA A CA   1 
ATOM   1461 C C    . ALA A 1 132 ? 33.437  -14.249 -0.869  1.00 17.65  ? 96  ALA A C    1 
ATOM   1462 O O    . ALA A 1 132 ? 34.593  -13.935 -0.889  1.00 18.62  ? 96  ALA A O    1 
ATOM   1463 C CB   . ALA A 1 132 ? 32.403  -15.863 0.628   1.00 19.86  ? 96  ALA A CB   1 
ATOM   1464 H H    . ALA A 1 132 ? 30.847  -13.955 -0.062  1.00 18.48  ? 96  ALA A H    1 
ATOM   1465 H HA   . ALA A 1 132 ? 33.303  -14.120 1.147   1.00 19.44  ? 96  ALA A HA   1 
ATOM   1466 H HB1  . ALA A 1 132 ? 32.633  -16.341 -0.174  1.00 23.83  ? 96  ALA A HB1  1 
ATOM   1467 H HB2  . ALA A 1 132 ? 31.465  -15.962 0.811   1.00 23.83  ? 96  ALA A HB2  1 
ATOM   1468 H HB3  . ALA A 1 132 ? 32.919  -16.197 1.366   1.00 23.83  ? 96  ALA A HB3  1 
ATOM   1469 N N    . TYR A 1 133 ? 32.732  -14.508 -1.959  1.00 18.54  ? 97  TYR A N    1 
ATOM   1470 C CA   . TYR A 1 133 ? 33.341  -14.410 -3.265  1.00 20.59  ? 97  TYR A CA   1 
ATOM   1471 C C    . TYR A 1 133 ? 33.174  -13.025 -3.862  1.00 17.31  ? 97  TYR A C    1 
ATOM   1472 O O    . TYR A 1 133 ? 32.082  -12.538 -3.969  1.00 19.71  ? 97  TYR A O    1 
ATOM   1473 C CB   . TYR A 1 133 ? 32.764  -15.463 -4.187  1.00 18.45  ? 97  TYR A CB   1 
ATOM   1474 C CG   . TYR A 1 133 ? 32.965  -16.822 -3.629  1.00 17.92  ? 97  TYR A CG   1 
ATOM   1475 C CD1  . TYR A 1 133 ? 34.233  -17.351 -3.490  1.00 23.74  ? 97  TYR A CD1  1 
ATOM   1476 C CD2  . TYR A 1 133 ? 31.896  -17.557 -3.186  1.00 22.98  ? 97  TYR A CD2  1 
ATOM   1477 C CE1  . TYR A 1 133 ? 34.425  -18.595 -2.946  1.00 24.35  ? 97  TYR A CE1  1 
ATOM   1478 C CE2  . TYR A 1 133 ? 32.074  -18.807 -2.657  1.00 19.80  ? 97  TYR A CE2  1 
ATOM   1479 C CZ   . TYR A 1 133 ? 33.335  -19.316 -2.523  1.00 30.19  ? 97  TYR A CZ   1 
ATOM   1480 O OH   . TYR A 1 133 ? 33.488  -20.555 -1.969  1.00 30.70  ? 97  TYR A OH   1 
ATOM   1481 H H    . TYR A 1 133 ? 31.904  -14.746 -1.983  1.00 22.23  ? 97  TYR A H    1 
ATOM   1482 H HA   . TYR A 1 133 ? 34.301  -14.589 -3.194  1.00 24.70  ? 97  TYR A HA   1 
ATOM   1483 H HB2  . TYR A 1 133 ? 31.811  -15.310 -4.288  1.00 22.13  ? 97  TYR A HB2  1 
ATOM   1484 H HB3  . TYR A 1 133 ? 33.210  -15.413 -5.047  1.00 22.13  ? 97  TYR A HB3  1 
ATOM   1485 H HD1  . TYR A 1 133 ? 34.968  -16.854 -3.770  1.00 28.48  ? 97  TYR A HD1  1 
ATOM   1486 H HD2  . TYR A 1 133 ? 31.038  -17.209 -3.271  1.00 27.57  ? 97  TYR A HD2  1 
ATOM   1487 H HE1  . TYR A 1 133 ? 35.283  -18.943 -2.859  1.00 29.20  ? 97  TYR A HE1  1 
ATOM   1488 H HH   . TYR A 1 133 ? 33.719  -20.474 -1.185  1.00 36.83  ? 97  TYR A HH   1 
ATOM   1489 N N    . ALA A 1 134 ? 34.290  -12.413 -4.245  1.00 17.98  ? 98  ALA A N    1 
ATOM   1490 C CA   . ALA A 1 134 ? 34.262  -11.070 -4.797  1.00 14.18  ? 98  ALA A CA   1 
ATOM   1491 C C    . ALA A 1 134 ? 33.944  -11.122 -6.292  1.00 20.50  ? 98  ALA A C    1 
ATOM   1492 O O    . ALA A 1 134 ? 34.726  -10.699 -7.142  1.00 21.53  ? 98  ALA A O    1 
ATOM   1493 C CB   . ALA A 1 134 ? 35.602  -10.383 -4.543  1.00 16.21  ? 98  ALA A CB   1 
ATOM   1494 H H    . ALA A 1 134 ? 35.080  -12.748 -4.185  1.00 21.57  ? 98  ALA A H    1 
ATOM   1495 H HA   . ALA A 1 134 ? 33.565  -10.558 -4.357  1.00 17.00  ? 98  ALA A HA   1 
ATOM   1496 H HB1  . ALA A 1 134 ? 35.612  -9.531  -5.005  1.00 19.44  ? 98  ALA A HB1  1 
ATOM   1497 H HB2  . ALA A 1 134 ? 35.709  -10.244 -3.589  1.00 19.44  ? 98  ALA A HB2  1 
ATOM   1498 H HB3  . ALA A 1 134 ? 36.315  -10.950 -4.877  1.00 19.44  ? 98  ALA A HB3  1 
ATOM   1499 N N    . TRP A 1 135 ? 32.775  -11.666 -6.600  1.00 18.41  ? 99  TRP A N    1 
ATOM   1500 C CA   . TRP A 1 135 ? 32.323  -11.730 -7.977  1.00 18.14  ? 99  TRP A CA   1 
ATOM   1501 C C    . TRP A 1 135 ? 32.406  -10.341 -8.596  1.00 20.02  ? 99  TRP A C    1 
ATOM   1502 O O    . TRP A 1 135 ? 31.792  -9.396  -8.069  1.00 19.84  ? 99  TRP A O    1 
ATOM   1503 C CB   . TRP A 1 135 ? 30.876  -12.214 -8.066  1.00 19.70  ? 99  TRP A CB   1 
ATOM   1504 C CG   . TRP A 1 135 ? 30.619  -13.596 -7.536  1.00 19.32  ? 99  TRP A CG   1 
ATOM   1505 C CD1  . TRP A 1 135 ? 29.852  -13.930 -6.455  1.00 20.43  ? 99  TRP A CD1  1 
ATOM   1506 C CD2  . TRP A 1 135 ? 31.109  -14.823 -8.073  1.00 23.98  ? 99  TRP A CD2  1 
ATOM   1507 N NE1  . TRP A 1 135 ? 29.841  -15.296 -6.281  1.00 25.89  ? 99  TRP A NE1  1 
ATOM   1508 C CE2  . TRP A 1 135 ? 30.603  -15.870 -7.260  1.00 23.56  ? 99  TRP A CE2  1 
ATOM   1509 C CE3  . TRP A 1 135 ? 31.926  -15.144 -9.159  1.00 29.60  ? 99  TRP A CE3  1 
ATOM   1510 C CZ2  . TRP A 1 135 ? 30.889  -17.213 -7.502  1.00 27.84  ? 99  TRP A CZ2  1 
ATOM   1511 C CZ3  . TRP A 1 135 ? 32.210  -16.490 -9.401  1.00 35.04  ? 99  TRP A CZ3  1 
ATOM   1512 C CH2  . TRP A 1 135 ? 31.692  -17.501 -8.577  1.00 30.77  ? 99  TRP A CH2  1 
ATOM   1513 H H    . TRP A 1 135 ? 32.226  -12.005 -6.030  1.00 22.08  ? 99  TRP A H    1 
ATOM   1514 H HA   . TRP A 1 135 ? 32.886  -12.354 -8.461  1.00 21.75  ? 99  TRP A HA   1 
ATOM   1515 H HB2  . TRP A 1 135 ? 30.318  -11.603 -7.559  1.00 23.62  ? 99  TRP A HB2  1 
ATOM   1516 H HB3  . TRP A 1 135 ? 30.610  -12.209 -8.999  1.00 23.62  ? 99  TRP A HB3  1 
ATOM   1517 H HD1  . TRP A 1 135 ? 29.402  -13.322 -5.915  1.00 24.51  ? 99  TRP A HD1  1 
ATOM   1518 H HE1  . TRP A 1 135 ? 29.423  -15.718 -5.659  1.00 31.05  ? 99  TRP A HE1  1 
ATOM   1519 H HE3  . TRP A 1 135 ? 32.273  -14.478 -9.708  1.00 35.51  ? 99  TRP A HE3  1 
ATOM   1520 H HZ2  . TRP A 1 135 ? 30.549  -17.886 -6.957  1.00 33.39  ? 99  TRP A HZ2  1 
ATOM   1521 H HZ3  . TRP A 1 135 ? 32.752  -16.720 -10.120 1.00 42.04  ? 99  TRP A HZ3  1 
ATOM   1522 H HH2  . TRP A 1 135 ? 31.898  -18.389 -8.764  1.00 36.92  ? 99  TRP A HH2  1 
ATOM   1523 N N    . PRO A 1 136 ? 33.089  -10.186 -9.755  1.00 21.11  ? 100 PRO A N    1 
ATOM   1524 C CA   . PRO A 1 136 ? 33.318  -8.848  -10.306 1.00 26.68  ? 100 PRO A CA   1 
ATOM   1525 C C    . PRO A 1 136 ? 32.188  -8.396  -11.208 1.00 29.21  ? 100 PRO A C    1 
ATOM   1526 O O    . PRO A 1 136 ? 32.439  -7.752  -12.225 1.00 28.01  ? 100 PRO A O    1 
ATOM   1527 C CB   . PRO A 1 136 ? 34.628  -9.023  -11.091 1.00 25.09  ? 100 PRO A CB   1 
ATOM   1528 C CG   . PRO A 1 136 ? 34.577  -10.476 -11.550 1.00 25.26  ? 100 PRO A CG   1 
ATOM   1529 C CD   . PRO A 1 136 ? 33.848  -11.228 -10.481 1.00 28.75  ? 100 PRO A CD   1 
ATOM   1530 H HA   . PRO A 1 136 ? 33.444  -8.199  -9.596  1.00 32.00  ? 100 PRO A HA   1 
ATOM   1531 H HB2  . PRO A 1 136 ? 34.651  -8.415  -11.846 1.00 30.09  ? 100 PRO A HB2  1 
ATOM   1532 H HB3  . PRO A 1 136 ? 35.390  -8.863  -10.513 1.00 30.09  ? 100 PRO A HB3  1 
ATOM   1533 H HG2  . PRO A 1 136 ? 34.101  -10.534 -12.394 1.00 30.30  ? 100 PRO A HG2  1 
ATOM   1534 H HG3  . PRO A 1 136 ? 35.479  -10.817 -11.654 1.00 30.30  ? 100 PRO A HG3  1 
ATOM   1535 H HD2  . PRO A 1 136 ? 33.245  -11.880 -10.872 1.00 34.49  ? 100 PRO A HD2  1 
ATOM   1536 H HD3  . PRO A 1 136 ? 34.474  -11.670 -9.887  1.00 34.49  ? 100 PRO A HD3  1 
ATOM   1537 N N    . PHE A 1 137 ? 30.941  -8.707  -10.854 1.00 22.13  ? 101 PHE A N    1 
ATOM   1538 C CA   . PHE A 1 137 ? 29.836  -8.485  -11.778 1.00 19.39  ? 101 PHE A CA   1 
ATOM   1539 C C    . PHE A 1 137 ? 29.156  -7.150  -11.594 1.00 20.75  ? 101 PHE A C    1 
ATOM   1540 O O    . PHE A 1 137 ? 28.515  -6.678  -12.532 1.00 22.99  ? 101 PHE A O    1 
ATOM   1541 C CB   . PHE A 1 137 ? 28.793  -9.578  -11.638 1.00 23.31  ? 101 PHE A CB   1 
ATOM   1542 C CG   . PHE A 1 137 ? 29.339  -10.936 -11.874 1.00 18.86  ? 101 PHE A CG   1 
ATOM   1543 C CD1  . PHE A 1 137 ? 30.419  -11.131 -12.732 1.00 31.77  ? 101 PHE A CD1  1 
ATOM   1544 C CD2  . PHE A 1 137 ? 28.794  -12.022 -11.241 1.00 20.17  ? 101 PHE A CD2  1 
ATOM   1545 C CE1  . PHE A 1 137 ? 30.934  -12.404 -12.944 1.00 33.34  ? 101 PHE A CE1  1 
ATOM   1546 C CE2  . PHE A 1 137 ? 29.299  -13.294 -11.455 1.00 24.96  ? 101 PHE A CE2  1 
ATOM   1547 C CZ   . PHE A 1 137 ? 30.361  -13.486 -12.306 1.00 30.80  ? 101 PHE A CZ   1 
ATOM   1548 H H    . PHE A 1 137 ? 30.715  -9.042  -10.095 1.00 26.54  ? 101 PHE A H    1 
ATOM   1549 H HA   . PHE A 1 137 ? 30.194  -8.520  -12.679 1.00 23.26  ? 101 PHE A HA   1 
ATOM   1550 H HB2  . PHE A 1 137 ? 28.430  -9.553  -10.739 1.00 27.97  ? 101 PHE A HB2  1 
ATOM   1551 H HB3  . PHE A 1 137 ? 28.087  -9.423  -12.285 1.00 27.97  ? 101 PHE A HB3  1 
ATOM   1552 H HD1  . PHE A 1 137 ? 30.799  -10.402 -13.168 1.00 38.12  ? 101 PHE A HD1  1 
ATOM   1553 H HD2  . PHE A 1 137 ? 28.077  -11.904 -10.661 1.00 24.20  ? 101 PHE A HD2  1 
ATOM   1554 H HE1  . PHE A 1 137 ? 31.660  -12.527 -13.511 1.00 40.00  ? 101 PHE A HE1  1 
ATOM   1555 H HE2  . PHE A 1 137 ? 28.916  -14.023 -11.021 1.00 29.95  ? 101 PHE A HE2  1 
ATOM   1556 H HZ   . PHE A 1 137 ? 30.693  -14.342 -12.451 1.00 36.95  ? 101 PHE A HZ   1 
ATOM   1557 N N    . THR A 1 138 ? 29.259  -6.567  -10.407 1.00 21.80  ? 102 THR A N    1 
ATOM   1558 C CA   . THR A 1 138 ? 28.777  -5.229  -10.114 1.00 16.57  ? 102 THR A CA   1 
ATOM   1559 C C    . THR A 1 138 ? 29.914  -4.227  -10.293 1.00 19.47  ? 102 THR A C    1 
ATOM   1560 O O    . THR A 1 138 ? 31.095  -4.571  -10.202 1.00 20.19  ? 102 THR A O    1 
ATOM   1561 C CB   . THR A 1 138 ? 28.260  -5.135  -8.680  1.00 17.80  ? 102 THR A CB   1 
ATOM   1562 O OG1  . THR A 1 138 ? 29.254  -5.608  -7.800  1.00 18.76  ? 102 THR A OG1  1 
ATOM   1563 C CG2  . THR A 1 138 ? 26.980  -5.972  -8.480  1.00 19.82  ? 102 THR A CG2  1 
ATOM   1564 H H    . THR A 1 138 ? 29.621  -6.945  -9.725  1.00 26.14  ? 102 THR A H    1 
ATOM   1565 H HA   . THR A 1 138 ? 28.048  -5.013  -10.716 1.00 19.88  ? 102 THR A HA   1 
ATOM   1566 H HB   . THR A 1 138 ? 28.044  -4.210  -8.484  1.00 21.35  ? 102 THR A HB   1 
ATOM   1567 H HG1  . THR A 1 138 ? 29.036  -5.444  -7.005  1.00 22.51  ? 102 THR A HG1  1 
ATOM   1568 H HG21 . THR A 1 138 ? 26.653  -5.868  -7.572  1.00 23.77  ? 102 THR A HG21 1 
ATOM   1569 H HG22 . THR A 1 138 ? 26.292  -5.678  -9.097  1.00 23.77  ? 102 THR A HG22 1 
ATOM   1570 H HG23 . THR A 1 138 ? 27.168  -6.910  -8.641  1.00 23.77  ? 102 THR A HG23 1 
ATOM   1571 N N    . SER A 1 139 ? 29.547  -2.977  -10.546 1.00 20.14  ? 103 SER A N    1 
ATOM   1572 C CA   . SER A 1 139 ? 30.568  -1.937  -10.541 1.00 22.29  ? 103 SER A CA   1 
ATOM   1573 C C    . SER A 1 139 ? 31.325  -1.932  -9.230  1.00 20.60  ? 103 SER A C    1 
ATOM   1574 O O    . SER A 1 139 ? 32.523  -1.626  -9.198  1.00 19.41  ? 103 SER A O    1 
ATOM   1575 C CB   . SER A 1 139 ? 29.935  -0.567  -10.801 1.00 22.80  ? 103 SER A CB   1 
ATOM   1576 O OG   . SER A 1 139 ? 29.104  -0.162  -9.720  1.00 25.47  ? 103 SER A OG   1 
ATOM   1577 H H    . SER A 1 139 ? 28.746  -2.714  -10.716 1.00 24.16  ? 103 SER A H    1 
ATOM   1578 H HA   . SER A 1 139 ? 31.197  -2.107  -11.260 1.00 26.74  ? 103 SER A HA   1 
ATOM   1579 H HB2  . SER A 1 139 ? 30.642  0.088   -10.914 1.00 27.35  ? 103 SER A HB2  1 
ATOM   1580 H HB3  . SER A 1 139 ? 29.398  -0.618  -11.607 1.00 27.35  ? 103 SER A HB3  1 
ATOM   1581 H HG   . SER A 1 139 ? 28.392  -0.607  -9.722  1.00 30.55  ? 103 SER A HG   1 
ATOM   1582 N N    . TYR A 1 140 ? 30.641  -2.253  -8.125  1.00 16.83  ? 104 TYR A N    1 
ATOM   1583 C CA   . TYR A 1 140 ? 31.273  -2.175  -6.819  1.00 20.46  ? 104 TYR A CA   1 
ATOM   1584 C C    . TYR A 1 140 ? 32.491  -3.079  -6.738  1.00 24.11  ? 104 TYR A C    1 
ATOM   1585 O O    . TYR A 1 140 ? 33.463  -2.747  -6.052  1.00 19.88  ? 104 TYR A O    1 
ATOM   1586 C CB   . TYR A 1 140 ? 30.279  -2.581  -5.727  1.00 21.92  ? 104 TYR A CB   1 
ATOM   1587 C CG   . TYR A 1 140 ? 28.942  -1.938  -5.909  1.00 20.05  ? 104 TYR A CG   1 
ATOM   1588 C CD1  . TYR A 1 140 ? 28.842  -0.579  -6.029  1.00 18.38  ? 104 TYR A CD1  1 
ATOM   1589 C CD2  . TYR A 1 140 ? 27.775  -2.698  -5.983  1.00 18.00  ? 104 TYR A CD2  1 
ATOM   1590 C CE1  . TYR A 1 140 ? 27.625  0.032   -6.209  1.00 18.51  ? 104 TYR A CE1  1 
ATOM   1591 C CE2  . TYR A 1 140 ? 26.561  -2.090  -6.160  1.00 16.69  ? 104 TYR A CE2  1 
ATOM   1592 C CZ   . TYR A 1 140 ? 26.496  -0.738  -6.275  1.00 18.96  ? 104 TYR A CZ   1 
ATOM   1593 O OH   . TYR A 1 140 ? 25.312  -0.117  -6.473  1.00 18.11  ? 104 TYR A OH   1 
ATOM   1594 H H    . TYR A 1 140 ? 29.822  -2.515  -8.111  1.00 20.18  ? 104 TYR A H    1 
ATOM   1595 H HA   . TYR A 1 140 ? 31.549  -1.257  -6.666  1.00 24.54  ? 104 TYR A HA   1 
ATOM   1596 H HB2  . TYR A 1 140 ? 30.158  -3.543  -5.751  1.00 26.29  ? 104 TYR A HB2  1 
ATOM   1597 H HB3  . TYR A 1 140 ? 30.629  -2.312  -4.863  1.00 26.29  ? 104 TYR A HB3  1 
ATOM   1598 H HD1  . TYR A 1 140 ? 29.612  -0.060  -5.987  1.00 22.04  ? 104 TYR A HD1  1 
ATOM   1599 H HD2  . TYR A 1 140 ? 27.821  -3.624  -5.912  1.00 21.59  ? 104 TYR A HD2  1 
ATOM   1600 H HE1  . TYR A 1 140 ? 27.569  0.957   -6.285  1.00 22.20  ? 104 TYR A HE1  1 
ATOM   1601 H HE2  . TYR A 1 140 ? 25.784  -2.600  -6.200  1.00 20.02  ? 104 TYR A HE2  1 
ATOM   1602 H HH   . TYR A 1 140 ? 25.412  0.715   -6.426  1.00 21.72  ? 104 TYR A HH   1 
ATOM   1603 N N    . ASN A 1 141 ? 32.439  -4.224  -7.419  1.00 18.47  ? 105 ASN A N    1 
ATOM   1604 C CA   . ASN A 1 141 ? 33.474  -5.244  -7.363  1.00 16.89  ? 105 ASN A CA   1 
ATOM   1605 C C    . ASN A 1 141 ? 34.366  -5.260  -8.614  1.00 21.74  ? 105 ASN A C    1 
ATOM   1606 O O    . ASN A 1 141 ? 35.113  -6.222  -8.832  1.00 20.25  ? 105 ASN A O    1 
ATOM   1607 C CB   . ASN A 1 141 ? 32.842  -6.631  -7.162  1.00 18.03  ? 105 ASN A CB   1 
ATOM   1608 C CG   . ASN A 1 141 ? 32.455  -6.911  -5.706  1.00 18.93  ? 105 ASN A CG   1 
ATOM   1609 O OD1  . ASN A 1 141 ? 32.567  -6.049  -4.841  1.00 18.21  ? 105 ASN A OD1  1 
ATOM   1610 N ND2  . ASN A 1 141 ? 31.988  -8.152  -5.443  1.00 17.95  ? 105 ASN A ND2  1 
ATOM   1611 H H    . ASN A 1 141 ? 31.788  -4.436  -7.939  1.00 22.15  ? 105 ASN A H    1 
ATOM   1612 H HA   . ASN A 1 141 ? 34.040  -5.050  -6.599  1.00 20.26  ? 105 ASN A HA   1 
ATOM   1613 H HB2  . ASN A 1 141 ? 32.038  -6.691  -7.701  1.00 21.63  ? 105 ASN A HB2  1 
ATOM   1614 H HB3  . ASN A 1 141 ? 33.478  -7.309  -7.438  1.00 21.63  ? 105 ASN A HB3  1 
ATOM   1615 H HD21 . ASN A 1 141 ? 31.756  -8.363  -4.642  1.00 21.53  ? 105 ASN A HD21 1 
ATOM   1616 H HD22 . ASN A 1 141 ? 31.922  -8.730  -6.076  1.00 21.53  ? 105 ASN A HD22 1 
ATOM   1617 N N    . GLN A 1 142 ? 34.337  -4.195  -9.407  1.00 20.76  ? 106 GLN A N    1 
ATOM   1618 C CA   . GLN A 1 142 ? 34.985  -4.230  -10.712 1.00 23.46  ? 106 GLN A CA   1 
ATOM   1619 C C    . GLN A 1 142 ? 36.493  -4.361  -10.579 1.00 28.40  ? 106 GLN A C    1 
ATOM   1620 O O    . GLN A 1 142 ? 37.129  -4.925  -11.475 1.00 27.32  ? 106 GLN A O    1 
ATOM   1621 C CB   . GLN A 1 142 ? 34.611  -2.987  -11.519 1.00 21.89  ? 106 GLN A CB   1 
ATOM   1622 C CG   . GLN A 1 142 ? 35.236  -1.708  -11.048 1.00 27.45  ? 106 GLN A CG   1 
ATOM   1623 H H    . GLN A 1 142 ? 33.953  -3.450  -9.217  1.00 24.90  ? 106 GLN A H    1 
ATOM   1624 H HA   . GLN A 1 142 ? 34.666  -4.997  -11.214 1.00 28.14  ? 106 GLN A HA   1 
ATOM   1625 H HB2  . GLN A 1 142 ? 34.888  -3.123  -12.438 1.00 26.26  ? 106 GLN A HB2  1 
ATOM   1626 H HB3  . GLN A 1 142 ? 33.648  -2.872  -11.476 1.00 26.26  ? 106 GLN A HB3  1 
ATOM   1627 N N    . ALA A 1 143 ? 37.063  -3.927  -9.456  1.00 25.97  ? 107 ALA A N    1 
ATOM   1628 C CA   . ALA A 1 143 ? 38.507  -3.997  -9.282  1.00 26.14  ? 107 ALA A CA   1 
ATOM   1629 C C    . ALA A 1 143 ? 38.999  -5.391  -8.931  1.00 24.02  ? 107 ALA A C    1 
ATOM   1630 O O    . ALA A 1 143 ? 40.209  -5.644  -8.985  1.00 24.43  ? 107 ALA A O    1 
ATOM   1631 C CB   . ALA A 1 143 ? 38.956  -3.032  -8.203  1.00 25.70  ? 107 ALA A CB   1 
ATOM   1632 H H    . ALA A 1 143 ? 36.638  -3.591  -8.788  1.00 31.15  ? 107 ALA A H    1 
ATOM   1633 H HA   . ALA A 1 143 ? 38.923  -3.732  -10.118 1.00 31.36  ? 107 ALA A HA   1 
ATOM   1634 H HB1  . ALA A 1 143 ? 39.919  -3.093  -8.105  1.00 30.83  ? 107 ALA A HB1  1 
ATOM   1635 H HB2  . ALA A 1 143 ? 38.707  -2.131  -8.461  1.00 30.83  ? 107 ALA A HB2  1 
ATOM   1636 H HB3  . ALA A 1 143 ? 38.523  -3.269  -7.367  1.00 30.83  ? 107 ALA A HB3  1 
ATOM   1637 N N    . PHE A 1 144 ? 38.105  -6.309  -8.585  1.00 26.05  ? 108 PHE A N    1 
ATOM   1638 C CA   . PHE A 1 144 ? 38.522  -7.620  -8.102  1.00 24.72  ? 108 PHE A CA   1 
ATOM   1639 C C    . PHE A 1 144 ? 38.762  -8.557  -9.283  1.00 28.96  ? 108 PHE A C    1 
ATOM   1640 O O    . PHE A 1 144 ? 38.109  -9.586  -9.452  1.00 20.01  ? 108 PHE A O    1 
ATOM   1641 C CB   . PHE A 1 144 ? 37.485  -8.180  -7.127  1.00 23.65  ? 108 PHE A CB   1 
ATOM   1642 C CG   . PHE A 1 144 ? 37.365  -7.381  -5.869  1.00 16.20  ? 108 PHE A CG   1 
ATOM   1643 C CD1  . PHE A 1 144 ? 38.413  -7.306  -4.986  1.00 21.39  ? 108 PHE A CD1  1 
ATOM   1644 C CD2  . PHE A 1 144 ? 36.220  -6.647  -5.594  1.00 20.62  ? 108 PHE A CD2  1 
ATOM   1645 C CE1  . PHE A 1 144 ? 38.332  -6.544  -3.837  1.00 21.86  ? 108 PHE A CE1  1 
ATOM   1646 C CE2  . PHE A 1 144 ? 36.131  -5.887  -4.444  1.00 20.67  ? 108 PHE A CE2  1 
ATOM   1647 C CZ   . PHE A 1 144 ? 37.174  -5.832  -3.566  1.00 21.38  ? 108 PHE A CZ   1 
ATOM   1648 H H    . PHE A 1 144 ? 37.253  -6.197  -8.621  1.00 31.24  ? 108 PHE A H    1 
ATOM   1649 H HA   . PHE A 1 144 ? 39.357  -7.531  -7.616  1.00 29.65  ? 108 PHE A HA   1 
ATOM   1650 H HB2  . PHE A 1 144 ? 36.617  -8.184  -7.561  1.00 28.36  ? 108 PHE A HB2  1 
ATOM   1651 H HB3  . PHE A 1 144 ? 37.738  -9.084  -6.884  1.00 28.36  ? 108 PHE A HB3  1 
ATOM   1652 H HD1  . PHE A 1 144 ? 39.194  -7.779  -5.164  1.00 25.66  ? 108 PHE A HD1  1 
ATOM   1653 H HD2  . PHE A 1 144 ? 35.506  -6.667  -6.189  1.00 24.73  ? 108 PHE A HD2  1 
ATOM   1654 H HE1  . PHE A 1 144 ? 39.051  -6.508  -3.248  1.00 26.22  ? 108 PHE A HE1  1 
ATOM   1655 H HE2  . PHE A 1 144 ? 35.354  -5.408  -4.266  1.00 24.79  ? 108 PHE A HE2  1 
ATOM   1656 H HZ   . PHE A 1 144 ? 37.108  -5.321  -2.792  1.00 25.64  ? 108 PHE A HZ   1 
ATOM   1657 N N    . THR A 1 145 ? 39.740  -8.164  -10.110 1.00 24.96  ? 109 THR A N    1 
ATOM   1658 C CA   . THR A 1 145 ? 40.179  -8.955  -11.243 1.00 27.45  ? 109 THR A CA   1 
ATOM   1659 C C    . THR A 1 145 ? 41.693  -9.077  -11.191 1.00 35.63  ? 109 THR A C    1 
ATOM   1660 O O    . THR A 1 145 ? 42.393  -8.226  -10.631 1.00 30.12  ? 109 THR A O    1 
ATOM   1661 C CB   . THR A 1 145 ? 39.783  -8.367  -12.593 1.00 29.06  ? 109 THR A CB   1 
ATOM   1662 O OG1  . THR A 1 145 ? 40.428  -7.107  -12.792 1.00 33.82  ? 109 THR A OG1  1 
ATOM   1663 C CG2  . THR A 1 145 ? 38.293  -8.162  -12.661 1.00 31.23  ? 109 THR A CG2  1 
ATOM   1664 H H    . THR A 1 145 ? 40.169  -7.423  -10.025 1.00 29.94  ? 109 THR A H    1 
ATOM   1665 H HA   . THR A 1 145 ? 39.766  -9.831  -11.181 1.00 32.93  ? 109 THR A HA   1 
ATOM   1666 H HB   . THR A 1 145 ? 40.052  -8.981  -13.293 1.00 34.86  ? 109 THR A HB   1 
ATOM   1667 H HG1  . THR A 1 145 ? 40.223  -6.795  -13.544 1.00 40.58  ? 109 THR A HG1  1 
ATOM   1668 H HG21 . THR A 1 145 ? 38.039  -7.871  -13.551 1.00 37.47  ? 109 THR A HG21 1 
ATOM   1669 H HG22 . THR A 1 145 ? 37.835  -8.992  -12.458 1.00 37.47  ? 109 THR A HG22 1 
ATOM   1670 H HG23 . THR A 1 145 ? 38.021  -7.487  -12.019 1.00 37.47  ? 109 THR A HG23 1 
ATOM   1671 N N    . ARG A 1 146 ? 42.176  -10.150 -11.794 1.00 34.79  ? 110 ARG A N    1 
ATOM   1672 C CA   . ARG A 1 146 ? 43.609  -10.392 -11.869 1.00 42.41  ? 110 ARG A CA   1 
ATOM   1673 C C    . ARG A 1 146 ? 44.347  -9.160  -12.371 1.00 42.84  ? 110 ARG A C    1 
ATOM   1674 O O    . ARG A 1 146 ? 45.408  -8.805  -11.839 1.00 43.66  ? 110 ARG A O    1 
ATOM   1675 C CB   . ARG A 1 146 ? 43.830  -11.613 -12.765 1.00 42.88  ? 110 ARG A CB   1 
ATOM   1676 C CG   . ARG A 1 146 ? 45.208  -12.220 -12.726 1.00 51.26  ? 110 ARG A CG   1 
ATOM   1677 C CD   . ARG A 1 146 ? 45.190  -13.554 -11.996 1.00 57.96  ? 110 ARG A CD   1 
ATOM   1678 N NE   . ARG A 1 146 ? 45.631  -13.365 -10.620 1.00 57.43  ? 110 ARG A NE   1 
ATOM   1679 C CZ   . ARG A 1 146 ? 45.390  -14.195 -9.616  1.00 51.55  ? 110 ARG A CZ   1 
ATOM   1680 N NH1  . ARG A 1 146 ? 44.680  -15.304 -9.782  1.00 39.32  ? 110 ARG A NH1  1 
ATOM   1681 N NH2  . ARG A 1 146 ? 45.877  -13.908 -8.412  1.00 55.47  ? 110 ARG A NH2  1 
ATOM   1682 H H    . ARG A 1 146 ? 41.696  -10.758 -12.169 1.00 41.74  ? 110 ARG A H    1 
ATOM   1683 H HA   . ARG A 1 146 ? 43.979  -10.588 -10.994 1.00 50.88  ? 110 ARG A HA   1 
ATOM   1684 H HB2  . ARG A 1 146 ? 43.205  -12.304 -12.495 1.00 51.44  ? 110 ARG A HB2  1 
ATOM   1685 H HB3  . ARG A 1 146 ? 43.659  -11.350 -13.683 1.00 51.44  ? 110 ARG A HB3  1 
ATOM   1686 H HG2  . ARG A 1 146 ? 45.522  -12.370 -13.631 1.00 61.50  ? 110 ARG A HG2  1 
ATOM   1687 H HG3  . ARG A 1 146 ? 45.813  -11.622 -12.260 1.00 61.50  ? 110 ARG A HG3  1 
ATOM   1688 H HD2  . ARG A 1 146 ? 44.288  -13.912 -11.989 1.00 69.55  ? 110 ARG A HD2  1 
ATOM   1689 H HD3  . ARG A 1 146 ? 45.791  -14.176 -12.434 1.00 69.55  ? 110 ARG A HD3  1 
ATOM   1690 H HE   . ARG A 1 146 ? 46.085  -12.656 -10.445 1.00 68.90  ? 110 ARG A HE   1 
ATOM   1691 H HH11 . ARG A 1 146 ? 44.363  -15.500 -10.557 1.00 47.17  ? 110 ARG A HH11 1 
ATOM   1692 H HH12 . ARG A 1 146 ? 44.537  -15.827 -9.114  1.00 47.17  ? 110 ARG A HH12 1 
ATOM   1693 H HH21 . ARG A 1 146 ? 46.340  -13.193 -8.295  1.00 66.56  ? 110 ARG A HH21 1 
ATOM   1694 H HH22 . ARG A 1 146 ? 45.729  -14.437 -7.750  1.00 66.56  ? 110 ARG A HH22 1 
ATOM   1695 N N    . ASN A 1 147 ? 43.764  -8.445  -13.340 1.00 37.09  ? 111 ASN A N    1 
ATOM   1696 C CA   . ASN A 1 147 ? 44.453  -7.347  -14.005 1.00 41.04  ? 111 ASN A CA   1 
ATOM   1697 C C    . ASN A 1 147 ? 44.236  -5.983  -13.365 1.00 46.06  ? 111 ASN A C    1 
ATOM   1698 O O    . ASN A 1 147 ? 44.938  -5.032  -13.736 1.00 44.52  ? 111 ASN A O    1 
ATOM   1699 C CB   . ASN A 1 147 ? 44.015  -7.256  -15.472 1.00 41.99  ? 111 ASN A CB   1 
ATOM   1700 C CG   . ASN A 1 147 ? 44.709  -8.279  -16.354 1.00 48.41  ? 111 ASN A CG   1 
ATOM   1701 O OD1  . ASN A 1 147 ? 44.329  -9.450  -16.394 1.00 55.16  ? 111 ASN A OD1  1 
ATOM   1702 N ND2  . ASN A 1 147 ? 45.744  -7.840  -17.058 1.00 54.24  ? 111 ASN A ND2  1 
ATOM   1703 H H    . ASN A 1 147 ? 42.966  -8.581  -13.628 1.00 44.50  ? 111 ASN A H    1 
ATOM   1704 H HA   . ASN A 1 147 ? 45.402  -7.543  -13.965 1.00 49.24  ? 111 ASN A HA   1 
ATOM   1705 H HB2  . ASN A 1 147 ? 43.059  -7.411  -15.527 1.00 50.37  ? 111 ASN A HB2  1 
ATOM   1706 H HB3  . ASN A 1 147 ? 44.228  -6.373  -15.812 1.00 50.37  ? 111 ASN A HB3  1 
ATOM   1707 H HD21 . ASN A 1 147 ? 45.986  -7.017  -16.998 1.00 65.07  ? 111 ASN A HD21 1 
ATOM   1708 H HD22 . ASN A 1 147 ? 46.172  -8.379  -17.574 1.00 65.07  ? 111 ASN A HD22 1 
ATOM   1709 N N    . LYS A 1 148 ? 43.273  -5.835  -12.446 1.00 31.74  ? 112 LYS A N    1 
ATOM   1710 C CA   . LYS A 1 148 ? 43.054  -4.541  -11.823 1.00 33.46  ? 112 LYS A CA   1 
ATOM   1711 C C    . LYS A 1 148 ? 43.381  -4.487  -10.341 1.00 30.14  ? 112 LYS A C    1 
ATOM   1712 O O    . LYS A 1 148 ? 43.582  -3.388  -9.817  1.00 35.28  ? 112 LYS A O    1 
ATOM   1713 C CB   . LYS A 1 148 ? 41.594  -4.105  -11.986 1.00 34.01  ? 112 LYS A CB   1 
ATOM   1714 C CG   . LYS A 1 148 ? 41.160  -3.841  -13.412 1.00 38.32  ? 112 LYS A CG   1 
ATOM   1715 C CD   . LYS A 1 148 ? 39.644  -3.864  -13.502 1.00 35.84  ? 112 LYS A CD   1 
ATOM   1716 C CE   . LYS A 1 148 ? 39.158  -3.618  -14.913 1.00 53.51  ? 112 LYS A CE   1 
ATOM   1717 N NZ   . LYS A 1 148 ? 37.825  -4.259  -15.111 1.00 58.84  ? 112 LYS A NZ   1 
ATOM   1718 H H    . LYS A 1 148 ? 42.748  -6.462  -12.177 1.00 38.08  ? 112 LYS A H    1 
ATOM   1719 H HA   . LYS A 1 148 ? 43.625  -3.904  -12.280 1.00 40.15  ? 112 LYS A HA   1 
ATOM   1720 H HB2  . LYS A 1 148 ? 41.023  -4.805  -11.633 1.00 40.80  ? 112 LYS A HB2  1 
ATOM   1721 H HB3  . LYS A 1 148 ? 41.461  -3.285  -11.485 1.00 40.80  ? 112 LYS A HB3  1 
ATOM   1722 H HG2  . LYS A 1 148 ? 41.477  -2.969  -13.695 1.00 45.98  ? 112 LYS A HG2  1 
ATOM   1723 H HG3  . LYS A 1 148 ? 41.518  -4.529  -13.996 1.00 45.98  ? 112 LYS A HG3  1 
ATOM   1724 H HD2  . LYS A 1 148 ? 39.319  -4.733  -13.218 1.00 43.00  ? 112 LYS A HD2  1 
ATOM   1725 H HD3  . LYS A 1 148 ? 39.279  -3.170  -12.931 1.00 43.00  ? 112 LYS A HD3  1 
ATOM   1726 H HE2  . LYS A 1 148 ? 39.070  -2.664  -15.067 1.00 64.20  ? 112 LYS A HE2  1 
ATOM   1727 H HE3  . LYS A 1 148 ? 39.785  -4.000  -15.546 1.00 64.20  ? 112 LYS A HE3  1 
ATOM   1728 H HZ1  . LYS A 1 148 ? 37.531  -4.101  -15.936 1.00 70.60  ? 112 LYS A HZ1  1 
ATOM   1729 H HZ2  . LYS A 1 148 ? 37.890  -5.139  -14.991 1.00 70.60  ? 112 LYS A HZ2  1 
ATOM   1730 H HZ3  . LYS A 1 148 ? 37.239  -3.930  -14.528 1.00 70.60  ? 112 LYS A HZ3  1 
ATOM   1731 N N    . ILE A 1 149 ? 43.434  -5.621  -9.650  1.00 26.82  ? 113 ILE A N    1 
ATOM   1732 C CA   . ILE A 1 149 ? 43.385  -5.567  -8.190  1.00 30.60  ? 113 ILE A CA   1 
ATOM   1733 C C    . ILE A 1 149 ? 44.622  -4.876  -7.630  1.00 35.15  ? 113 ILE A C    1 
ATOM   1734 O O    . ILE A 1 149 ? 44.535  -4.111  -6.665  1.00 28.29  ? 113 ILE A O    1 
ATOM   1735 C CB   . ILE A 1 149 ? 43.195  -6.973  -7.600  1.00 28.42  ? 113 ILE A CB   1 
ATOM   1736 C CG1  . ILE A 1 149 ? 42.991  -6.886  -6.090  1.00 30.22  ? 113 ILE A CG1  1 
ATOM   1737 C CG2  . ILE A 1 149 ? 44.357  -7.899  -7.967  1.00 34.76  ? 113 ILE A CG2  1 
ATOM   1738 C CD1  . ILE A 1 149 ? 41.820  -6.053  -5.724  1.00 26.54  ? 113 ILE A CD1  1 
ATOM   1739 H H    . ILE A 1 149 ? 43.496  -6.409  -9.988  1.00 32.18  ? 113 ILE A H    1 
ATOM   1740 H HA   . ILE A 1 149 ? 42.614  -5.037  -7.935  1.00 36.71  ? 113 ILE A HA   1 
ATOM   1741 H HB   . ILE A 1 149 ? 42.397  -7.361  -7.991  1.00 34.09  ? 113 ILE A HB   1 
ATOM   1742 H HG12 . ILE A 1 149 ? 42.849  -7.778  -5.737  1.00 36.25  ? 113 ILE A HG12 1 
ATOM   1743 H HG13 . ILE A 1 149 ? 43.780  -6.491  -5.686  1.00 36.25  ? 113 ILE A HG13 1 
ATOM   1744 H HG21 . ILE A 1 149 ? 44.153  -8.797  -7.661  1.00 41.70  ? 113 ILE A HG21 1 
ATOM   1745 H HG22 . ILE A 1 149 ? 44.471  -7.896  -8.930  1.00 41.70  ? 113 ILE A HG22 1 
ATOM   1746 H HG23 . ILE A 1 149 ? 45.165  -7.578  -7.536  1.00 41.70  ? 113 ILE A HG23 1 
ATOM   1747 H HD11 . ILE A 1 149 ? 41.517  -6.306  -4.838  1.00 31.84  ? 113 ILE A HD11 1 
ATOM   1748 H HD12 . ILE A 1 149 ? 42.082  -5.119  -5.730  1.00 31.84  ? 113 ILE A HD12 1 
ATOM   1749 H HD13 . ILE A 1 149 ? 41.112  -6.202  -6.371  1.00 31.84  ? 113 ILE A HD13 1 
ATOM   1750 N N    . ASP A 1 150 ? 45.791  -5.129  -8.220  1.00 39.18  ? 114 ASP A N    1 
ATOM   1751 C CA   . ASP A 1 150 ? 47.005  -4.516  -7.699  1.00 36.56  ? 114 ASP A CA   1 
ATOM   1752 C C    . ASP A 1 150 ? 46.925  -3.001  -7.748  1.00 31.69  ? 114 ASP A C    1 
ATOM   1753 O O    . ASP A 1 150 ? 47.541  -2.323  -6.917  1.00 38.16  ? 114 ASP A O    1 
ATOM   1754 C CB   . ASP A 1 150 ? 48.215  -5.008  -8.488  1.00 39.31  ? 114 ASP A CB   1 
ATOM   1755 C CG   . ASP A 1 150 ? 48.674  -6.385  -8.058  1.00 42.78  ? 114 ASP A CG   1 
ATOM   1756 O OD1  . ASP A 1 150 ? 47.955  -7.071  -7.303  1.00 39.11  ? 114 ASP A OD1  1 
ATOM   1757 O OD2  . ASP A 1 150 ? 49.759  -6.806  -8.514  1.00 51.46  ? 114 ASP A OD2  1 
ATOM   1758 H H    . ASP A 1 150 ? 45.903  -5.639  -8.903  1.00 47.00  ? 114 ASP A H    1 
ATOM   1759 H HA   . ASP A 1 150 ? 47.121  -4.782  -6.774  1.00 43.87  ? 114 ASP A HA   1 
ATOM   1760 H HB2  . ASP A 1 150 ? 47.984  -5.049  -9.429  1.00 47.16  ? 114 ASP A HB2  1 
ATOM   1761 H HB3  . ASP A 1 150 ? 48.952  -4.391  -8.355  1.00 47.16  ? 114 ASP A HB3  1 
ATOM   1762 N N    . GLU A 1 151 ? 46.190  -2.452  -8.715  1.00 31.65  ? 115 GLU A N    1 
ATOM   1763 C CA   . GLU A 1 151 ? 45.968  -1.013  -8.817  1.00 35.09  ? 115 GLU A CA   1 
ATOM   1764 C C    . GLU A 1 151 ? 45.036  -0.472  -7.746  1.00 36.17  ? 115 GLU A C    1 
ATOM   1765 O O    . GLU A 1 151 ? 44.831  0.747   -7.688  1.00 33.88  ? 115 GLU A O    1 
ATOM   1766 C CB   . GLU A 1 151 ? 45.401  -0.663  -10.195 1.00 43.25  ? 115 GLU A CB   1 
ATOM   1767 C CG   . GLU A 1 151 ? 46.113  -1.366  -11.334 1.00 46.46  ? 115 GLU A CG   1 
ATOM   1768 C CD   . GLU A 1 151 ? 47.607  -1.081  -11.314 1.00 57.99  ? 115 GLU A CD   1 
ATOM   1769 O OE1  . GLU A 1 151 ? 47.996  0.113   -11.241 1.00 48.73  ? 115 GLU A OE1  1 
ATOM   1770 O OE2  . GLU A 1 151 ? 48.389  -2.059  -11.329 1.00 65.33  ? 115 GLU A OE2  1 
ATOM   1771 H H    . GLU A 1 151 ? 45.801  -2.902  -9.336  1.00 37.97  ? 115 GLU A H    1 
ATOM   1772 H HA   . GLU A 1 151 ? 46.827  -0.573  -8.718  1.00 42.10  ? 115 GLU A HA   1 
ATOM   1773 H HB2  . GLU A 1 151 ? 44.466  -0.920  -10.224 1.00 51.89  ? 115 GLU A HB2  1 
ATOM   1774 H HB3  . GLU A 1 151 ? 45.487  0.293   -10.336 1.00 51.89  ? 115 GLU A HB3  1 
ATOM   1775 H HG2  . GLU A 1 151 ? 45.983  -2.324  -11.251 1.00 55.74  ? 115 GLU A HG2  1 
ATOM   1776 H HG3  . GLU A 1 151 ? 45.753  -1.055  -12.179 1.00 55.74  ? 115 GLU A HG3  1 
ATOM   1777 N N    . HIS A 1 152 ? 44.457  -1.336  -6.914  1.00 29.79  ? 116 HIS A N    1 
ATOM   1778 C CA   . HIS A 1 152 ? 43.567  -0.930  -5.827  1.00 29.26  ? 116 HIS A CA   1 
ATOM   1779 C C    . HIS A 1 152 ? 44.063  -1.550  -4.535  1.00 29.59  ? 116 HIS A C    1 
ATOM   1780 O O    . HIS A 1 152 ? 43.490  -2.528  -4.036  1.00 26.75  ? 116 HIS A O    1 
ATOM   1781 C CB   . HIS A 1 152 ? 42.136  -1.361  -6.147  1.00 27.46  ? 116 HIS A CB   1 
ATOM   1782 C CG   . HIS A 1 152 ? 41.614  -0.768  -7.409  1.00 22.15  ? 116 HIS A CG   1 
ATOM   1783 N ND1  . HIS A 1 152 ? 41.846  -1.330  -8.646  1.00 33.37  ? 116 HIS A ND1  1 
ATOM   1784 C CD2  . HIS A 1 152 ? 40.862  0.334   -7.630  1.00 26.83  ? 116 HIS A CD2  1 
ATOM   1785 C CE1  . HIS A 1 152 ? 41.260  -0.597  -9.574  1.00 28.56  ? 116 HIS A CE1  1 
ATOM   1786 N NE2  . HIS A 1 152 ? 40.653  0.418   -8.983  1.00 28.90  ? 116 HIS A NE2  1 
ATOM   1787 H H    . HIS A 1 152 ? 44.569  -2.187  -6.960  1.00 35.73  ? 116 HIS A H    1 
ATOM   1788 H HA   . HIS A 1 152 ? 43.583  0.034   -5.716  1.00 35.10  ? 116 HIS A HA   1 
ATOM   1789 H HB2  . HIS A 1 152 ? 42.112  -2.326  -6.238  1.00 32.94  ? 116 HIS A HB2  1 
ATOM   1790 H HB3  . HIS A 1 152 ? 41.555  -1.081  -5.422  1.00 32.94  ? 116 HIS A HB3  1 
ATOM   1791 H HD1  . HIS A 1 152 ? 42.302  -2.045  -8.791  1.00 40.03  ? 116 HIS A HD1  1 
ATOM   1792 H HD2  . HIS A 1 152 ? 40.546  0.925   -6.985  1.00 32.19  ? 116 HIS A HD2  1 
ATOM   1793 H HE1  . HIS A 1 152 ? 41.271  -0.765  -10.488 1.00 34.26  ? 116 HIS A HE1  1 
ATOM   1794 N N    . PRO A 1 153 ? 45.165  -1.030  -3.982  1.00 30.07  ? 117 PRO A N    1 
ATOM   1795 C CA   . PRO A 1 153 ? 45.795  -1.716  -2.844  1.00 28.50  ? 117 PRO A CA   1 
ATOM   1796 C C    . PRO A 1 153 ? 44.909  -1.810  -1.615  1.00 28.15  ? 117 PRO A C    1 
ATOM   1797 O O    . PRO A 1 153 ? 44.962  -2.834  -0.923  1.00 23.29  ? 117 PRO A O    1 
ATOM   1798 C CB   . PRO A 1 153 ? 47.059  -0.879  -2.577  1.00 29.52  ? 117 PRO A CB   1 
ATOM   1799 C CG   . PRO A 1 153 ? 46.826  0.414   -3.273  1.00 31.63  ? 117 PRO A CG   1 
ATOM   1800 C CD   . PRO A 1 153 ? 45.972  0.115   -4.450  1.00 31.49  ? 117 PRO A CD   1 
ATOM   1801 H HA   . PRO A 1 153 ? 46.056  -2.611  -3.112  1.00 34.19  ? 117 PRO A HA   1 
ATOM   1802 H HB2  . PRO A 1 153 ? 47.169  -0.743  -1.622  1.00 35.41  ? 117 PRO A HB2  1 
ATOM   1803 H HB3  . PRO A 1 153 ? 47.837  -1.332  -2.938  1.00 35.41  ? 117 PRO A HB3  1 
ATOM   1804 H HG2  . PRO A 1 153 ? 46.376  1.029   -2.673  1.00 37.94  ? 117 PRO A HG2  1 
ATOM   1805 H HG3  . PRO A 1 153 ? 47.676  0.788   -3.555  1.00 37.94  ? 117 PRO A HG3  1 
ATOM   1806 H HD2  . PRO A 1 153 ? 45.407  0.872   -4.671  1.00 37.78  ? 117 PRO A HD2  1 
ATOM   1807 H HD3  . PRO A 1 153 ? 46.512  -0.131  -5.218  1.00 37.78  ? 117 PRO A HD3  1 
ATOM   1808 N N    . LYS A 1 154 ? 44.074  -0.802  -1.336  1.00 29.09  ? 118 LYS A N    1 
ATOM   1809 C CA   . LYS A 1 154 ? 43.181  -0.907  -0.186  1.00 29.61  ? 118 LYS A CA   1 
ATOM   1810 C C    . LYS A 1 154 ? 42.188  -2.058  -0.372  1.00 21.73  ? 118 LYS A C    1 
ATOM   1811 O O    . LYS A 1 154 ? 41.980  -2.867  0.541   1.00 23.55  ? 118 LYS A O    1 
ATOM   1812 C CB   . LYS A 1 154 ? 42.437  0.408   0.037   1.00 30.22  ? 118 LYS A CB   1 
ATOM   1813 C CG   . LYS A 1 154 ? 41.613  0.485   1.321   1.00 31.24  ? 118 LYS A CG   1 
ATOM   1814 C CD   . LYS A 1 154 ? 42.297  -0.095  2.554   1.00 37.98  ? 118 LYS A CD   1 
ATOM   1815 C CE   . LYS A 1 154 ? 43.147  0.965   3.272   1.00 45.25  ? 118 LYS A CE   1 
ATOM   1816 N NZ   . LYS A 1 154 ? 43.342  0.684   4.726   1.00 42.64  ? 118 LYS A NZ   1 
ATOM   1817 H H    . LYS A 1 154 ? 44.009  -0.071  -1.784  1.00 34.89  ? 118 LYS A H    1 
ATOM   1818 H HA   . LYS A 1 154 ? 43.715  -1.084  0.604   1.00 35.52  ? 118 LYS A HA   1 
ATOM   1819 H HB2  . LYS A 1 154 ? 43.089  1.126   0.068   1.00 36.25  ? 118 LYS A HB2  1 
ATOM   1820 H HB3  . LYS A 1 154 ? 41.828  0.545   -0.705  1.00 36.25  ? 118 LYS A HB3  1 
ATOM   1821 H HG2  . LYS A 1 154 ? 41.419  1.417   1.508   1.00 37.48  ? 118 LYS A HG2  1 
ATOM   1822 H HG3  . LYS A 1 154 ? 40.787  -0.006  1.188   1.00 37.48  ? 118 LYS A HG3  1 
ATOM   1823 H HD2  . LYS A 1 154 ? 41.623  -0.418  3.174   1.00 45.57  ? 118 LYS A HD2  1 
ATOM   1824 H HD3  . LYS A 1 154 ? 42.878  -0.824  2.287   1.00 45.57  ? 118 LYS A HD3  1 
ATOM   1825 H HE2  . LYS A 1 154 ? 44.022  0.999   2.856   1.00 54.29  ? 118 LYS A HE2  1 
ATOM   1826 H HE3  . LYS A 1 154 ? 42.708  1.826   3.193   1.00 54.29  ? 118 LYS A HE3  1 
ATOM   1827 H HZ1  . LYS A 1 154 ? 43.817  1.337   5.100   1.00 51.16  ? 118 LYS A HZ1  1 
ATOM   1828 H HZ2  . LYS A 1 154 ? 42.554  0.630   5.134   1.00 51.16  ? 118 LYS A HZ2  1 
ATOM   1829 H HZ3  . LYS A 1 154 ? 43.776  -0.086  4.831   1.00 51.16  ? 118 LYS A HZ3  1 
ATOM   1830 N N    . LEU A 1 155 ? 41.569  -2.137  -1.551  1.00 23.73  ? 119 LEU A N    1 
ATOM   1831 C CA   . LEU A 1 155 ? 40.638  -3.236  -1.815  1.00 20.40  ? 119 LEU A CA   1 
ATOM   1832 C C    . LEU A 1 155 ? 41.373  -4.561  -1.772  1.00 24.11  ? 119 LEU A C    1 
ATOM   1833 O O    . LEU A 1 155 ? 40.897  -5.533  -1.192  1.00 20.87  ? 119 LEU A O    1 
ATOM   1834 C CB   . LEU A 1 155 ? 39.969  -3.022  -3.165  1.00 21.34  ? 119 LEU A CB   1 
ATOM   1835 C CG   . LEU A 1 155 ? 39.006  -1.828  -3.244  1.00 25.66  ? 119 LEU A CG   1 
ATOM   1836 C CD1  . LEU A 1 155 ? 38.273  -1.779  -4.590  1.00 30.77  ? 119 LEU A CD1  1 
ATOM   1837 C CD2  . LEU A 1 155 ? 38.027  -1.896  -2.091  1.00 24.52  ? 119 LEU A CD2  1 
ATOM   1838 H H    . LEU A 1 155 ? 41.668  -1.582  -2.200  1.00 28.46  ? 119 LEU A H    1 
ATOM   1839 H HA   . LEU A 1 155 ? 39.940  -3.253  -1.141  1.00 24.47  ? 119 LEU A HA   1 
ATOM   1840 H HB2  . LEU A 1 155 ? 40.662  -2.879  -3.828  1.00 25.60  ? 119 LEU A HB2  1 
ATOM   1841 H HB3  . LEU A 1 155 ? 39.461  -3.818  -3.383  1.00 25.60  ? 119 LEU A HB3  1 
ATOM   1842 H HG   . LEU A 1 155 ? 39.513  -1.003  -3.177  1.00 30.78  ? 119 LEU A HG   1 
ATOM   1843 H HD11 . LEU A 1 155 ? 37.644  -1.040  -4.580  1.00 36.91  ? 119 LEU A HD11 1 
ATOM   1844 H HD12 . LEU A 1 155 ? 38.922  -1.651  -5.299  1.00 36.91  ? 119 LEU A HD12 1 
ATOM   1845 H HD13 . LEU A 1 155 ? 37.799  -2.615  -4.721  1.00 36.91  ? 119 LEU A HD13 1 
ATOM   1846 H HD21 . LEU A 1 155 ? 37.238  -1.379  -2.316  1.00 29.42  ? 119 LEU A HD21 1 
ATOM   1847 H HD22 . LEU A 1 155 ? 37.783  -2.823  -1.939  1.00 29.42  ? 119 LEU A HD22 1 
ATOM   1848 H HD23 . LEU A 1 155 ? 38.447  -1.530  -1.297  1.00 29.42  ? 119 LEU A HD23 1 
ATOM   1849 N N    . LYS A 1 156 ? 42.577  -4.602  -2.335  1.00 23.27  ? 120 LYS A N    1 
ATOM   1850 C CA   . LYS A 1 156 ? 43.359  -5.833  -2.281  1.00 21.94  ? 120 LYS A CA   1 
ATOM   1851 C C    . LYS A 1 156 ? 43.611  -6.297  -0.854  1.00 21.43  ? 120 LYS A C    1 
ATOM   1852 O O    . LYS A 1 156 ? 43.655  -7.506  -0.580  1.00 21.17  ? 120 LYS A O    1 
ATOM   1853 C CB   . LYS A 1 156 ? 44.683  -5.602  -3.006  1.00 28.98  ? 120 LYS A CB   1 
ATOM   1854 C CG   . LYS A 1 156 ? 45.532  -6.845  -3.098  1.00 30.92  ? 120 LYS A CG   1 
ATOM   1855 C CD   . LYS A 1 156 ? 46.617  -6.654  -4.147  1.00 31.53  ? 120 LYS A CD   1 
ATOM   1856 C CE   . LYS A 1 156 ? 47.625  -7.782  -4.099  1.00 45.86  ? 120 LYS A CE   1 
ATOM   1857 N NZ   . LYS A 1 156 ? 48.895  -7.439  -4.815  1.00 46.23  ? 120 LYS A NZ   1 
ATOM   1858 H H    . LYS A 1 156 ? 42.956  -3.948  -2.745  1.00 27.92  ? 120 LYS A H    1 
ATOM   1859 H HA   . LYS A 1 156 ? 42.864  -6.540  -2.724  1.00 26.32  ? 120 LYS A HA   1 
ATOM   1860 H HB2  . LYS A 1 156 ? 44.498  -5.298  -3.908  1.00 34.76  ? 120 LYS A HB2  1 
ATOM   1861 H HB3  . LYS A 1 156 ? 45.190  -4.928  -2.526  1.00 34.76  ? 120 LYS A HB3  1 
ATOM   1862 H HG2  . LYS A 1 156 ? 45.954  -7.018  -2.242  1.00 37.09  ? 120 LYS A HG2  1 
ATOM   1863 H HG3  . LYS A 1 156 ? 44.981  -7.601  -3.354  1.00 37.09  ? 120 LYS A HG3  1 
ATOM   1864 H HD2  . LYS A 1 156 ? 46.214  -6.640  -5.030  1.00 37.82  ? 120 LYS A HD2  1 
ATOM   1865 H HD3  . LYS A 1 156 ? 47.083  -5.819  -3.982  1.00 37.82  ? 120 LYS A HD3  1 
ATOM   1866 H HE2  . LYS A 1 156 ? 47.842  -7.976  -3.174  1.00 55.02  ? 120 LYS A HE2  1 
ATOM   1867 H HE3  . LYS A 1 156 ? 47.243  -8.568  -4.521  1.00 55.02  ? 120 LYS A HE3  1 
ATOM   1868 H HZ1  . LYS A 1 156 ? 49.465  -8.121  -4.768  1.00 55.46  ? 120 LYS A HZ1  1 
ATOM   1869 H HZ2  . LYS A 1 156 ? 48.725  -7.263  -5.670  1.00 55.46  ? 120 LYS A HZ2  1 
ATOM   1870 H HZ3  . LYS A 1 156 ? 49.271  -6.723  -4.442  1.00 55.46  ? 120 LYS A HZ3  1 
ATOM   1871 N N    . SER A 1 157 ? 43.809  -5.362  0.067   1.00 19.96  ? 121 SER A N    1 
ATOM   1872 C CA   . SER A 1 157 ? 44.113  -5.711  1.444   1.00 23.51  ? 121 SER A CA   1 
ATOM   1873 C C    . SER A 1 157 ? 42.921  -6.344  2.152   1.00 22.04  ? 121 SER A C    1 
ATOM   1874 O O    . SER A 1 157 ? 43.080  -6.866  3.250   1.00 22.90  ? 121 SER A O    1 
ATOM   1875 C CB   . SER A 1 157 ? 44.583  -4.476  2.219   1.00 26.35  ? 121 SER A CB   1 
ATOM   1876 O OG   . SER A 1 157 ? 43.527  -3.580  2.544   1.00 25.73  ? 121 SER A OG   1 
ATOM   1877 H H    . SER A 1 157 ? 43.772  -4.516  -0.081  1.00 23.94  ? 121 SER A H    1 
ATOM   1878 H HA   . SER A 1 157 ? 44.843  -6.350  1.449   1.00 28.20  ? 121 SER A HA   1 
ATOM   1879 H HB2  . SER A 1 157 ? 44.997  -4.772  3.044   1.00 31.61  ? 121 SER A HB2  1 
ATOM   1880 H HB3  . SER A 1 157 ? 45.230  -4.001  1.674   1.00 31.61  ? 121 SER A HB3  1 
ATOM   1881 H HG   . SER A 1 157 ? 43.188  -3.269  1.841   1.00 30.86  ? 121 SER A HG   1 
ATOM   1882 N N    . PHE A 1 158 ? 41.733  -6.258  1.567   1.00 23.37  ? 122 PHE A N    1 
ATOM   1883 C CA   . PHE A 1 158 ? 40.546  -6.871  2.132   1.00 20.28  ? 122 PHE A CA   1 
ATOM   1884 C C    . PHE A 1 158 ? 40.439  -8.356  1.846   1.00 23.06  ? 122 PHE A C    1 
ATOM   1885 O O    . PHE A 1 158 ? 39.454  -8.972  2.255   1.00 19.62  ? 122 PHE A O    1 
ATOM   1886 C CB   . PHE A 1 158 ? 39.296  -6.217  1.550   1.00 17.78  ? 122 PHE A CB   1 
ATOM   1887 C CG   . PHE A 1 158 ? 39.144  -4.755  1.893   1.00 21.50  ? 122 PHE A CG   1 
ATOM   1888 C CD1  . PHE A 1 158 ? 39.814  -4.176  2.937   1.00 22.15  ? 122 PHE A CD1  1 
ATOM   1889 C CD2  . PHE A 1 158 ? 38.277  -3.990  1.153   1.00 20.40  ? 122 PHE A CD2  1 
ATOM   1890 C CE1  . PHE A 1 158 ? 39.626  -2.822  3.216   1.00 24.67  ? 122 PHE A CE1  1 
ATOM   1891 C CE2  . PHE A 1 158 ? 38.096  -2.676  1.415   1.00 22.12  ? 122 PHE A CE2  1 
ATOM   1892 C CZ   . PHE A 1 158 ? 38.783  -2.094  2.461   1.00 22.85  ? 122 PHE A CZ   1 
ATOM   1893 H H    . PHE A 1 158 ? 41.588  -5.841  0.829   1.00 28.03  ? 122 PHE A H    1 
ATOM   1894 H HA   . PHE A 1 158 ? 40.580  -6.733  3.091   1.00 24.33  ? 122 PHE A HA   1 
ATOM   1895 H HB2  . PHE A 1 158 ? 39.330  -6.290  0.583   1.00 21.33  ? 122 PHE A HB2  1 
ATOM   1896 H HB3  . PHE A 1 158 ? 38.516  -6.682  1.891   1.00 21.33  ? 122 PHE A HB3  1 
ATOM   1897 H HD1  . PHE A 1 158 ? 40.392  -4.684  3.459   1.00 26.58  ? 122 PHE A HD1  1 
ATOM   1898 H HD2  . PHE A 1 158 ? 37.803  -4.383  0.456   1.00 24.47  ? 122 PHE A HD2  1 
ATOM   1899 H HE1  . PHE A 1 158 ? 40.082  -2.424  3.922   1.00 29.59  ? 122 PHE A HE1  1 
ATOM   1900 H HE2  . PHE A 1 158 ? 37.515  -2.169  0.895   1.00 26.54  ? 122 PHE A HE2  1 
ATOM   1901 H HZ   . PHE A 1 158 ? 38.661  -1.190  2.646   1.00 27.41  ? 122 PHE A HZ   1 
ATOM   1902 N N    . LEU A 1 159 ? 41.376  -8.931  1.099   1.00 21.42  ? 123 LEU A N    1 
ATOM   1903 C CA   . LEU A 1 159 ? 41.195  -10.257 0.548   1.00 20.55  ? 123 LEU A CA   1 
ATOM   1904 C C    . LEU A 1 159 ? 42.085  -11.252 1.263   1.00 22.94  ? 123 LEU A C    1 
ATOM   1905 O O    . LEU A 1 159 ? 43.154  -10.911 1.759   1.00 26.23  ? 123 LEU A O    1 
ATOM   1906 C CB   . LEU A 1 159 ? 41.494  -10.276 -0.949  1.00 22.64  ? 123 LEU A CB   1 
ATOM   1907 C CG   . LEU A 1 159 ? 40.757  -9.239  -1.772  1.00 26.38  ? 123 LEU A CG   1 
ATOM   1908 C CD1  . LEU A 1 159 ? 41.284  -9.195  -3.160  1.00 23.57  ? 123 LEU A CD1  1 
ATOM   1909 C CD2  . LEU A 1 159 ? 39.301  -9.611  -1.782  1.00 21.07  ? 123 LEU A CD2  1 
ATOM   1910 H H    . LEU A 1 159 ? 42.128  -8.565  0.899   1.00 25.70  ? 123 LEU A H    1 
ATOM   1911 H HA   . LEU A 1 159 ? 40.274  -10.534 0.676   1.00 24.65  ? 123 LEU A HA   1 
ATOM   1912 H HB2  . LEU A 1 159 ? 42.444  -10.123 -1.072  1.00 27.15  ? 123 LEU A HB2  1 
ATOM   1913 H HB3  . LEU A 1 159 ? 41.252  -11.149 -1.297  1.00 27.15  ? 123 LEU A HB3  1 
ATOM   1914 H HG   . LEU A 1 159 ? 40.877  -8.356  -1.390  1.00 31.65  ? 123 LEU A HG   1 
ATOM   1915 H HD11 . LEU A 1 159 ? 40.695  -8.650  -3.704  1.00 28.27  ? 123 LEU A HD11 1 
ATOM   1916 H HD12 . LEU A 1 159 ? 42.174  -8.810  -3.147  1.00 28.27  ? 123 LEU A HD12 1 
ATOM   1917 H HD13 . LEU A 1 159 ? 41.320  -10.098 -3.513  1.00 28.27  ? 123 LEU A HD13 1 
ATOM   1918 H HD21 . LEU A 1 159 ? 38.831  -9.030  -2.402  1.00 25.27  ? 123 LEU A HD21 1 
ATOM   1919 H HD22 . LEU A 1 159 ? 39.213  -10.535 -2.064  1.00 25.27  ? 123 LEU A HD22 1 
ATOM   1920 H HD23 . LEU A 1 159 ? 38.940  -9.502  -0.889  1.00 25.27  ? 123 LEU A HD23 1 
ATOM   1921 N N    . ILE A 1 160 ? 41.594  -12.485 1.339   1.00 21.65  ? 124 ILE A N    1 
ATOM   1922 C CA   . ILE A 1 160 ? 42.373  -13.561 1.920   1.00 21.40  ? 124 ILE A CA   1 
ATOM   1923 C C    . ILE A 1 160 ? 43.571  -13.847 1.028   1.00 22.09  ? 124 ILE A C    1 
ATOM   1924 O O    . ILE A 1 160 ? 43.467  -13.884 -0.208  1.00 23.67  ? 124 ILE A O    1 
ATOM   1925 C CB   . ILE A 1 160 ? 41.487  -14.804 2.108   1.00 26.00  ? 124 ILE A CB   1 
ATOM   1926 C CG1  . ILE A 1 160 ? 40.351  -14.486 3.081   1.00 22.38  ? 124 ILE A CG1  1 
ATOM   1927 C CG2  . ILE A 1 160 ? 42.292  -15.974 2.630   1.00 27.83  ? 124 ILE A CG2  1 
ATOM   1928 C CD1  . ILE A 1 160 ? 39.387  -15.612 3.284   1.00 20.86  ? 124 ILE A CD1  1 
ATOM   1929 H H    . ILE A 1 160 ? 40.814  -12.721 1.061   1.00 25.97  ? 124 ILE A H    1 
ATOM   1930 H HA   . ILE A 1 160 ? 42.705  -13.297 2.793   1.00 25.67  ? 124 ILE A HA   1 
ATOM   1931 H HB   . ILE A 1 160 ? 41.121  -15.045 1.243   1.00 31.19  ? 124 ILE A HB   1 
ATOM   1932 H HG12 . ILE A 1 160 ? 40.735  -14.267 3.945   1.00 26.84  ? 124 ILE A HG12 1 
ATOM   1933 H HG13 . ILE A 1 160 ? 39.852  -13.729 2.738   1.00 26.84  ? 124 ILE A HG13 1 
ATOM   1934 H HG21 . ILE A 1 160 ? 41.702  -16.734 2.751   1.00 33.38  ? 124 ILE A HG21 1 
ATOM   1935 H HG22 . ILE A 1 160 ? 42.986  -16.191 1.989   1.00 33.38  ? 124 ILE A HG22 1 
ATOM   1936 H HG23 . ILE A 1 160 ? 42.692  -15.728 3.479   1.00 33.38  ? 124 ILE A HG23 1 
ATOM   1937 H HD11 . ILE A 1 160 ? 38.582  -15.267 3.702   1.00 25.02  ? 124 ILE A HD11 1 
ATOM   1938 H HD12 . ILE A 1 160 ? 39.172  -16.003 2.423   1.00 25.02  ? 124 ILE A HD12 1 
ATOM   1939 H HD13 . ILE A 1 160 ? 39.797  -16.279 3.857   1.00 25.02  ? 124 ILE A HD13 1 
ATOM   1940 N N    . VAL A 1 161 ? 44.721  -14.040 1.661   1.00 24.87  ? 125 VAL A N    1 
ATOM   1941 C CA   . VAL A 1 161 ? 45.929  -14.490 0.991   1.00 24.95  ? 125 VAL A CA   1 
ATOM   1942 C C    . VAL A 1 161 ? 46.105  -15.974 1.252   1.00 28.22  ? 125 VAL A C    1 
ATOM   1943 O O    . VAL A 1 161 ? 45.996  -16.435 2.397   1.00 24.97  ? 125 VAL A O    1 
ATOM   1944 C CB   . VAL A 1 161 ? 47.158  -13.706 1.468   1.00 30.46  ? 125 VAL A CB   1 
ATOM   1945 C CG1  . VAL A 1 161 ? 48.317  -13.910 0.488   1.00 41.99  ? 125 VAL A CG1  1 
ATOM   1946 C CG2  . VAL A 1 161 ? 46.844  -12.234 1.542   1.00 29.63  ? 125 VAL A CG2  1 
ATOM   1947 H H    . VAL A 1 161 ? 44.827  -13.912 2.504   1.00 29.83  ? 125 VAL A H    1 
ATOM   1948 H HA   . VAL A 1 161 ? 45.829  -14.354 0.036   1.00 29.93  ? 125 VAL A HA   1 
ATOM   1949 H HB   . VAL A 1 161 ? 47.410  -14.027 2.349   1.00 36.55  ? 125 VAL A HB   1 
ATOM   1950 H HG11 . VAL A 1 161 ? 49.087  -13.410 0.801   1.00 50.38  ? 125 VAL A HG11 1 
ATOM   1951 H HG12 . VAL A 1 161 ? 48.531  -14.855 0.444   1.00 50.38  ? 125 VAL A HG12 1 
ATOM   1952 H HG13 . VAL A 1 161 ? 48.049  -13.590 -0.388  1.00 50.38  ? 125 VAL A HG13 1 
ATOM   1953 H HG21 . VAL A 1 161 ? 47.635  -11.756 1.837   1.00 35.54  ? 125 VAL A HG21 1 
ATOM   1954 H HG22 . VAL A 1 161 ? 46.578  -11.923 0.662   1.00 35.54  ? 125 VAL A HG22 1 
ATOM   1955 H HG23 . VAL A 1 161 ? 46.120  -12.097 2.173   1.00 35.54  ? 125 VAL A HG23 1 
ATOM   1956 N N    . ASP A 1 162 ? 46.402  -16.708 0.192   1.00 30.48  ? 126 ASP A N    1 
ATOM   1957 C CA   . ASP A 1 162 ? 46.718  -18.121 0.286   1.00 29.71  ? 126 ASP A CA   1 
ATOM   1958 C C    . ASP A 1 162 ? 48.102  -18.252 0.901   1.00 29.59  ? 126 ASP A C    1 
ATOM   1959 O O    . ASP A 1 162 ? 49.077  -17.812 0.284   1.00 29.96  ? 126 ASP A O    1 
ATOM   1960 C CB   . ASP A 1 162 ? 46.674  -18.756 -1.091  1.00 31.47  ? 126 ASP A CB   1 
ATOM   1961 C CG   . ASP A 1 162 ? 46.927  -20.254 -1.047  1.00 33.92  ? 126 ASP A CG   1 
ATOM   1962 O OD1  . ASP A 1 162 ? 47.237  -20.787 0.039   1.00 28.53  ? 126 ASP A OD1  1 
ATOM   1963 O OD2  . ASP A 1 162 ? 46.773  -20.891 -2.103  1.00 28.76  ? 126 ASP A OD2  1 
ATOM   1964 H H    . ASP A 1 162 ? 46.428  -16.404 -0.612  1.00 36.56  ? 126 ASP A H    1 
ATOM   1965 H HA   . ASP A 1 162 ? 46.071  -18.586 0.840   1.00 35.65  ? 126 ASP A HA   1 
ATOM   1966 H HB2  . ASP A 1 162 ? 45.798  -18.609 -1.480  1.00 37.76  ? 126 ASP A HB2  1 
ATOM   1967 H HB3  . ASP A 1 162 ? 47.357  -18.351 -1.649  1.00 37.76  ? 126 ASP A HB3  1 
ATOM   1968 N N    . PRO A 1 163 ? 48.243  -18.771 2.118   1.00 32.18  ? 127 PRO A N    1 
ATOM   1969 C CA   . PRO A 1 163 ? 49.599  -18.892 2.685   1.00 35.04  ? 127 PRO A CA   1 
ATOM   1970 C C    . PRO A 1 163 ? 50.514  -19.773 1.841   1.00 36.77  ? 127 PRO A C    1 
ATOM   1971 O O    . PRO A 1 163 ? 51.746  -19.646 1.927   1.00 32.43  ? 127 PRO A O    1 
ATOM   1972 C CB   . PRO A 1 163 ? 49.350  -19.491 4.076   1.00 36.72  ? 127 PRO A CB   1 
ATOM   1973 C CG   . PRO A 1 163 ? 48.025  -20.177 3.966   1.00 37.78  ? 127 PRO A CG   1 
ATOM   1974 C CD   . PRO A 1 163 ? 47.219  -19.319 3.018   1.00 34.88  ? 127 PRO A CD   1 
ATOM   1975 H HA   . PRO A 1 163 ? 50.003  -18.017 2.795   1.00 42.04  ? 127 PRO A HA   1 
ATOM   1976 H HB2  . PRO A 1 163 ? 50.052  -20.124 4.293   1.00 44.06  ? 127 PRO A HB2  1 
ATOM   1977 H HB3  . PRO A 1 163 ? 49.323  -18.784 4.740   1.00 44.06  ? 127 PRO A HB3  1 
ATOM   1978 H HG2  . PRO A 1 163 ? 48.143  -21.071 3.609   1.00 45.32  ? 127 PRO A HG2  1 
ATOM   1979 H HG3  . PRO A 1 163 ? 47.602  -20.221 4.838   1.00 45.32  ? 127 PRO A HG3  1 
ATOM   1980 H HD2  . PRO A 1 163 ? 46.576  -19.854 2.527   1.00 41.84  ? 127 PRO A HD2  1 
ATOM   1981 H HD3  . PRO A 1 163 ? 46.762  -18.609 3.497   1.00 41.84  ? 127 PRO A HD3  1 
ATOM   1982 N N    . LYS A 1 164 ? 49.954  -20.655 1.016   1.00 37.06  ? 128 LYS A N    1 
ATOM   1983 C CA   . LYS A 1 164 ? 50.796  -21.533 0.217   1.00 38.09  ? 128 LYS A CA   1 
ATOM   1984 C C    . LYS A 1 164 ? 51.483  -20.783 -0.909  1.00 39.21  ? 128 LYS A C    1 
ATOM   1985 O O    . LYS A 1 164 ? 52.520  -21.244 -1.402  1.00 31.07  ? 128 LYS A O    1 
ATOM   1986 C CB   . LYS A 1 164 ? 49.975  -22.687 -0.349  1.00 31.58  ? 128 LYS A CB   1 
ATOM   1987 C CG   . LYS A 1 164 ? 49.409  -23.577 0.704   1.00 25.72  ? 128 LYS A CG   1 
ATOM   1988 C CD   . LYS A 1 164 ? 48.242  -24.366 0.171   1.00 25.37  ? 128 LYS A CD   1 
ATOM   1989 C CE   . LYS A 1 164 ? 47.918  -25.511 1.058   1.00 28.25  ? 128 LYS A CE   1 
ATOM   1990 N NZ   . LYS A 1 164 ? 46.627  -26.159 0.705   1.00 27.89  ? 128 LYS A NZ   1 
ATOM   1991 H H    . LYS A 1 164 ? 49.108  -20.761 0.904   1.00 44.46  ? 128 LYS A H    1 
ATOM   1992 H HA   . LYS A 1 164 ? 51.481  -21.916 0.788   1.00 45.69  ? 128 LYS A HA   1 
ATOM   1993 H HB2  . LYS A 1 164 ? 49.236  -22.325 -0.862  1.00 37.88  ? 128 LYS A HB2  1 
ATOM   1994 H HB3  . LYS A 1 164 ? 50.543  -23.226 -0.921  1.00 37.88  ? 128 LYS A HB3  1 
ATOM   1995 H HG2  . LYS A 1 164 ? 50.090  -24.200 1.002   1.00 30.86  ? 128 LYS A HG2  1 
ATOM   1996 H HG3  . LYS A 1 164 ? 49.101  -23.040 1.451   1.00 30.86  ? 128 LYS A HG3  1 
ATOM   1997 H HD2  . LYS A 1 164 ? 47.462  -23.791 0.115   1.00 30.43  ? 128 LYS A HD2  1 
ATOM   1998 H HD3  . LYS A 1 164 ? 48.461  -24.712 -0.708  1.00 30.43  ? 128 LYS A HD3  1 
ATOM   1999 H HE2  . LYS A 1 164 ? 48.619  -26.177 0.984   1.00 33.89  ? 128 LYS A HE2  1 
ATOM   2000 H HE3  . LYS A 1 164 ? 47.856  -25.195 1.973   1.00 33.89  ? 128 LYS A HE3  1 
ATOM   2001 H HZ1  . LYS A 1 164 ? 46.446  -26.812 1.283   1.00 33.46  ? 128 LYS A HZ1  1 
ATOM   2002 H HZ2  . LYS A 1 164 ? 45.969  -25.561 0.730   1.00 33.46  ? 128 LYS A HZ2  1 
ATOM   2003 H HZ3  . LYS A 1 164 ? 46.673  -26.504 -0.114  1.00 33.46  ? 128 LYS A HZ3  1 
ATOM   2004 N N    . THR A 1 165 ? 50.945  -19.632 -1.311  1.00 30.34  ? 129 THR A N    1 
ATOM   2005 C CA   . THR A 1 165 ? 51.517  -18.854 -2.392  1.00 34.65  ? 129 THR A CA   1 
ATOM   2006 C C    . THR A 1 165 ? 51.954  -17.457 -1.986  1.00 40.29  ? 129 THR A C    1 
ATOM   2007 O O    . THR A 1 165 ? 52.724  -16.835 -2.733  1.00 35.97  ? 129 THR A O    1 
ATOM   2008 C CB   . THR A 1 165 ? 50.515  -18.711 -3.548  1.00 37.00  ? 129 THR A CB   1 
ATOM   2009 O OG1  . THR A 1 165 ? 49.428  -17.860 -3.143  1.00 32.38  ? 129 THR A OG1  1 
ATOM   2010 C CG2  . THR A 1 165 ? 49.985  -20.069 -3.968  1.00 36.95  ? 129 THR A CG2  1 
ATOM   2011 H H    . THR A 1 165 ? 50.240  -19.282 -0.965  1.00 36.40  ? 129 THR A H    1 
ATOM   2012 H HA   . THR A 1 165 ? 52.295  -19.330 -2.722  1.00 41.57  ? 129 THR A HA   1 
ATOM   2013 H HB   . THR A 1 165 ? 50.956  -18.314 -4.315  1.00 44.39  ? 129 THR A HB   1 
ATOM   2014 H HG1  . THR A 1 165 ? 48.979  -17.629 -3.814  1.00 38.85  ? 129 THR A HG1  1 
ATOM   2015 H HG21 . THR A 1 165 ? 49.752  -20.058 -4.910  1.00 44.33  ? 129 THR A HG21 1 
ATOM   2016 H HG22 . THR A 1 165 ? 50.660  -20.749 -3.819  1.00 44.33  ? 129 THR A HG22 1 
ATOM   2017 H HG23 . THR A 1 165 ? 49.194  -20.291 -3.451  1.00 44.33  ? 129 THR A HG23 1 
ATOM   2018 N N    . ALA A 1 166 ? 51.492  -16.953 -0.838  1.00 37.67  ? 130 ALA A N    1 
ATOM   2019 C CA   . ALA A 1 166 ? 51.607  -15.536 -0.485  1.00 45.48  ? 130 ALA A CA   1 
ATOM   2020 C C    . ALA A 1 166 ? 50.997  -14.644 -1.563  1.00 44.64  ? 130 ALA A C    1 
ATOM   2021 O O    . ALA A 1 166 ? 51.357  -13.468 -1.694  1.00 36.61  ? 130 ALA A O    1 
ATOM   2022 C CB   . ALA A 1 166 ? 53.063  -15.129 -0.225  1.00 52.61  ? 130 ALA A CB   1 
ATOM   2023 H H    . ALA A 1 166 ? 51.100  -17.423 -0.234  1.00 45.20  ? 130 ALA A H    1 
ATOM   2024 H HA   . ALA A 1 166 ? 51.115  -15.391 0.338   1.00 54.56  ? 130 ALA A HA   1 
ATOM   2025 H HB1  . ALA A 1 166 ? 53.090  -14.194 0.030   1.00 63.12  ? 130 ALA A HB1  1 
ATOM   2026 H HB2  . ALA A 1 166 ? 53.421  -15.678 0.490   1.00 63.12  ? 130 ALA A HB2  1 
ATOM   2027 H HB3  . ALA A 1 166 ? 53.579  -15.266 -1.036  1.00 63.12  ? 130 ALA A HB3  1 
ATOM   2028 N N    . GLU A 1 167 ? 50.088  -15.194 -2.360  1.00 34.28  ? 131 GLU A N    1 
ATOM   2029 C CA   . GLU A 1 167 ? 49.314  -14.417 -3.310  1.00 38.13  ? 131 GLU A CA   1 
ATOM   2030 C C    . GLU A 1 167 ? 47.843  -14.599 -2.953  1.00 28.96  ? 131 GLU A C    1 
ATOM   2031 O O    . GLU A 1 167 ? 47.486  -15.418 -2.101  1.00 27.63  ? 131 GLU A O    1 
ATOM   2032 C CB   . GLU A 1 167 ? 49.582  -14.834 -4.763  1.00 46.23  ? 131 GLU A CB   1 
ATOM   2033 C CG   . GLU A 1 167 ? 51.054  -14.912 -5.154  1.00 50.52  ? 131 GLU A CG   1 
ATOM   2034 C CD   . GLU A 1 167 ? 51.255  -15.342 -6.602  1.00 49.13  ? 131 GLU A CD   1 
ATOM   2035 H H    . GLU A 1 167 ? 49.902  -16.033 -2.367  1.00 41.12  ? 131 GLU A H    1 
ATOM   2036 H HA   . GLU A 1 167 ? 49.555  -13.479 -3.251  1.00 45.75  ? 131 GLU A HA   1 
ATOM   2037 H HB2  . GLU A 1 167 ? 49.197  -15.713 -4.905  1.00 55.47  ? 131 GLU A HB2  1 
ATOM   2038 H HB3  . GLU A 1 167 ? 49.159  -14.188 -5.350  1.00 55.47  ? 131 GLU A HB3  1 
ATOM   2039 H HG2  . GLU A 1 167 ? 51.458  -14.038 -5.042  1.00 60.62  ? 131 GLU A HG2  1 
ATOM   2040 H HG3  . GLU A 1 167 ? 51.499  -15.559 -4.585  1.00 60.62  ? 131 GLU A HG3  1 
ATOM   2041 N N    . LEU A 1 168 ? 47.003  -13.815 -3.605  1.00 30.35  ? 132 LEU A N    1 
ATOM   2042 C CA   . LEU A 1 168 ? 45.585  -13.820 -3.269  1.00 30.23  ? 132 LEU A CA   1 
ATOM   2043 C C    . LEU A 1 168 ? 45.000  -15.206 -3.461  1.00 28.62  ? 132 LEU A C    1 
ATOM   2044 O O    . LEU A 1 168 ? 45.206  -15.829 -4.507  1.00 28.94  ? 132 LEU A O    1 
ATOM   2045 C CB   . LEU A 1 168 ? 44.836  -12.833 -4.145  1.00 27.39  ? 132 LEU A CB   1 
ATOM   2046 C CG   . LEU A 1 168 ? 45.256  -11.375 -3.980  1.00 28.02  ? 132 LEU A CG   1 
ATOM   2047 C CD1  . LEU A 1 168 ? 44.470  -10.519 -4.927  1.00 31.20  ? 132 LEU A CD1  1 
ATOM   2048 C CD2  . LEU A 1 168 ? 45.092  -10.932 -2.559  1.00 28.47  ? 132 LEU A CD2  1 
ATOM   2049 H H    . LEU A 1 168 ? 47.222  -13.275 -4.238  1.00 36.40  ? 132 LEU A H    1 
ATOM   2050 H HA   . LEU A 1 168 ? 45.481  -13.559 -2.341  1.00 36.27  ? 132 LEU A HA   1 
ATOM   2051 H HB2  . LEU A 1 168 ? 44.981  -13.075 -5.073  1.00 32.86  ? 132 LEU A HB2  1 
ATOM   2052 H HB3  . LEU A 1 168 ? 43.891  -12.890 -3.932  1.00 32.86  ? 132 LEU A HB3  1 
ATOM   2053 H HG   . LEU A 1 168 ? 46.197  -11.275 -4.195  1.00 33.61  ? 132 LEU A HG   1 
ATOM   2054 H HD11 . LEU A 1 168 ? 44.729  -9.593  -4.804  1.00 37.43  ? 132 LEU A HD11 1 
ATOM   2055 H HD12 . LEU A 1 168 ? 44.658  -10.798 -5.836  1.00 37.43  ? 132 LEU A HD12 1 
ATOM   2056 H HD13 . LEU A 1 168 ? 43.524  -10.625 -4.737  1.00 37.43  ? 132 LEU A HD13 1 
ATOM   2057 H HD21 . LEU A 1 168 ? 45.164  -9.965  -2.520  1.00 34.15  ? 132 LEU A HD21 1 
ATOM   2058 H HD22 . LEU A 1 168 ? 44.221  -11.213 -2.239  1.00 34.15  ? 132 LEU A HD22 1 
ATOM   2059 H HD23 . LEU A 1 168 ? 45.789  -11.337 -2.020  1.00 34.15  ? 132 LEU A HD23 1 
ATOM   2060 N N    . ALA A 1 169 ? 44.256  -15.681 -2.465  1.00 27.81  ? 133 ALA A N    1 
ATOM   2061 C CA   . ALA A 1 169 ? 43.453  -16.884 -2.656  1.00 27.07  ? 133 ALA A CA   1 
ATOM   2062 C C    . ALA A 1 169 ? 42.383  -16.610 -3.711  1.00 30.17  ? 133 ALA A C    1 
ATOM   2063 O O    . ALA A 1 169 ? 41.936  -15.473 -3.898  1.00 24.76  ? 133 ALA A O    1 
ATOM   2064 C CB   . ALA A 1 169 ? 42.816  -17.328 -1.340  1.00 26.97  ? 133 ALA A CB   1 
ATOM   2065 H H    . ALA A 1 169 ? 44.200  -15.332 -1.681  1.00 33.36  ? 133 ALA A H    1 
ATOM   2066 H HA   . ALA A 1 169 ? 44.012  -17.616 -2.959  1.00 32.47  ? 133 ALA A HA   1 
ATOM   2067 H HB1  . ALA A 1 169 ? 42.284  -18.124 -1.499  1.00 32.35  ? 133 ALA A HB1  1 
ATOM   2068 H HB2  . ALA A 1 169 ? 43.518  -17.522 -0.700  1.00 32.35  ? 133 ALA A HB2  1 
ATOM   2069 H HB3  . ALA A 1 169 ? 42.251  -16.614 -1.006  1.00 32.35  ? 133 ALA A HB3  1 
ATOM   2070 N N    . HIS A 1 170 ? 42.001  -17.646 -4.448  1.00 24.88  ? 134 HIS A N    1 
ATOM   2071 C CA   . HIS A 1 170 ? 41.054  -17.407 -5.516  1.00 28.39  ? 134 HIS A CA   1 
ATOM   2072 C C    . HIS A 1 170 ? 40.426  -18.706 -5.967  1.00 30.99  ? 134 HIS A C    1 
ATOM   2073 O O    . HIS A 1 170 ? 40.940  -19.798 -5.735  1.00 28.46  ? 134 HIS A O    1 
ATOM   2074 C CB   . HIS A 1 170 ? 41.689  -16.696 -6.724  1.00 31.09  ? 134 HIS A CB   1 
ATOM   2075 C CG   . HIS A 1 170 ? 42.705  -17.511 -7.472  1.00 36.73  ? 134 HIS A CG   1 
ATOM   2076 N ND1  . HIS A 1 170 ? 42.426  -18.139 -8.666  1.00 31.91  ? 134 HIS A ND1  1 
ATOM   2077 C CD2  . HIS A 1 170 ? 44.017  -17.740 -7.230  1.00 36.96  ? 134 HIS A CD2  1 
ATOM   2078 C CE1  . HIS A 1 170 ? 43.508  -18.752 -9.109  1.00 41.18  ? 134 HIS A CE1  1 
ATOM   2079 N NE2  . HIS A 1 170 ? 44.488  -18.530 -8.254  1.00 42.54  ? 134 HIS A NE2  1 
ATOM   2080 H H    . HIS A 1 170 ? 42.266  -18.459 -4.350  1.00 29.84  ? 134 HIS A H    1 
ATOM   2081 H HA   . HIS A 1 170 ? 40.356  -16.841 -5.153  1.00 34.06  ? 134 HIS A HA   1 
ATOM   2082 H HB2  . HIS A 1 170 ? 40.985  -16.462 -7.349  1.00 37.29  ? 134 HIS A HB2  1 
ATOM   2083 H HB3  . HIS A 1 170 ? 42.134  -15.893 -6.410  1.00 37.29  ? 134 HIS A HB3  1 
ATOM   2084 H HD2  . HIS A 1 170 ? 44.508  -17.422 -6.507  1.00 44.34  ? 134 HIS A HD2  1 
ATOM   2085 H HE1  . HIS A 1 170 ? 43.568  -19.254 -9.890  1.00 49.41  ? 134 HIS A HE1  1 
ATOM   2086 H HE2  . HIS A 1 170 ? 45.290  -18.830 -8.325  1.00 51.04  ? 134 HIS A HE2  1 
ATOM   2087 N N    . ARG A 1 171 ? 39.305  -18.544 -6.653  1.00 27.25  ? 135 ARG A N    1 
ATOM   2088 C CA   . ARG A 1 171 ? 38.608  -19.665 -7.241  1.00 30.58  ? 135 ARG A CA   1 
ATOM   2089 C C    . ARG A 1 171 ? 38.426  -19.209 -8.680  1.00 28.73  ? 135 ARG A C    1 
ATOM   2090 O O    . ARG A 1 171 ? 37.613  -18.362 -8.944  1.00 28.22  ? 135 ARG A O    1 
ATOM   2091 C CB   . ARG A 1 171 ? 37.288  -19.886 -6.517  1.00 27.88  ? 135 ARG A CB   1 
ATOM   2092 C CG   . ARG A 1 171 ? 36.216  -20.652 -7.239  1.00 37.22  ? 135 ARG A CG   1 
ATOM   2093 C CD   . ARG A 1 171 ? 34.910  -20.310 -6.571  1.00 32.92  ? 135 ARG A CD   1 
ATOM   2094 N NE   . ARG A 1 171 ? 33.863  -21.259 -6.878  1.00 37.82  ? 135 ARG A NE   1 
ATOM   2095 C CZ   . ARG A 1 171 ? 32.611  -21.144 -6.455  1.00 46.03  ? 135 ARG A CZ   1 
ATOM   2096 N NH1  . ARG A 1 171 ? 32.232  -20.114 -5.705  1.00 32.98  ? 135 ARG A NH1  1 
ATOM   2097 N NH2  . ARG A 1 171 ? 31.727  -22.066 -6.797  1.00 50.90  ? 135 ARG A NH2  1 
ATOM   2098 H H    . ARG A 1 171 ? 38.911  -17.790 -6.805  1.00 32.69  ? 135 ARG A H    1 
ATOM   2099 H HA   . ARG A 1 171 ? 39.143  -20.482 -7.222  1.00 36.69  ? 135 ARG A HA   1 
ATOM   2100 H HB2  . ARG A 1 171 ? 37.473  -20.352 -5.688  1.00 33.45  ? 135 ARG A HB2  1 
ATOM   2101 H HB3  . ARG A 1 171 ? 36.918  -19.013 -6.312  1.00 33.45  ? 135 ARG A HB3  1 
ATOM   2102 H HG2  . ARG A 1 171 ? 36.167  -20.389 -8.170  1.00 44.66  ? 135 ARG A HG2  1 
ATOM   2103 H HG3  . ARG A 1 171 ? 36.372  -21.603 -7.154  1.00 44.66  ? 135 ARG A HG3  1 
ATOM   2104 H HD2  . ARG A 1 171 ? 35.038  -20.297 -5.610  1.00 39.50  ? 135 ARG A HD2  1 
ATOM   2105 H HD3  . ARG A 1 171 ? 34.621  -19.437 -6.878  1.00 39.50  ? 135 ARG A HD3  1 
ATOM   2106 H HE   . ARG A 1 171 ? 34.036  -21.884 -7.598  1.00 45.38  ? 135 ARG A HE   1 
ATOM   2107 H HH11 . ARG A 1 171 ? 32.791  -19.503 -5.473  1.00 39.57  ? 135 ARG A HH11 1 
ATOM   2108 H HH12 . ARG A 1 171 ? 31.416  -20.058 -5.443  1.00 39.57  ? 135 ARG A HH12 1 
ATOM   2109 H HH21 . ARG A 1 171 ? 31.968  -22.733 -7.283  1.00 61.07  ? 135 ARG A HH21 1 
ATOM   2110 H HH22 . ARG A 1 171 ? 30.913  -21.999 -6.528  1.00 61.07  ? 135 ARG A HH22 1 
ATOM   2111 N N    . ARG A 1 172 ? 39.229  -19.739 -9.597  1.00 30.46  ? 136 ARG A N    1 
ATOM   2112 C CA   . ARG A 1 172 ? 39.161  -19.266 -10.975 1.00 39.17  ? 136 ARG A CA   1 
ATOM   2113 C C    . ARG A 1 172 ? 39.337  -17.752 -11.041 1.00 35.47  ? 136 ARG A C    1 
ATOM   2114 O O    . ARG A 1 172 ? 38.622  -17.054 -11.761 1.00 33.77  ? 136 ARG A O    1 
ATOM   2115 C CB   . ARG A 1 172 ? 37.837  -19.665 -11.621 1.00 43.56  ? 136 ARG A CB   1 
ATOM   2116 C CG   . ARG A 1 172 ? 37.417  -21.111 -11.382 1.00 40.84  ? 136 ARG A CG   1 
ATOM   2117 C CD   . ARG A 1 172 ? 36.656  -21.642 -12.582 1.00 40.96  ? 136 ARG A CD   1 
ATOM   2118 N NE   . ARG A 1 172 ? 37.374  -21.407 -13.828 1.00 48.29  ? 136 ARG A NE   1 
ATOM   2119 C CZ   . ARG A 1 172 ? 36.929  -21.762 -15.023 1.00 54.01  ? 136 ARG A CZ   1 
ATOM   2120 N NH1  . ARG A 1 172 ? 35.778  -22.409 -15.166 1.00 48.91  ? 136 ARG A NH1  1 
ATOM   2121 N NH2  . ARG A 1 172 ? 37.646  -21.453 -16.100 1.00 49.44  ? 136 ARG A NH2  1 
ATOM   2122 H H    . ARG A 1 172 ? 39.814  -20.352 -9.450  1.00 36.54  ? 136 ARG A H    1 
ATOM   2123 H HA   . ARG A 1 172 ? 39.885  -19.676 -11.474 1.00 46.99  ? 136 ARG A HA   1 
ATOM   2124 H HB2  . ARG A 1 172 ? 37.137  -19.095 -11.265 1.00 52.26  ? 136 ARG A HB2  1 
ATOM   2125 H HB3  . ARG A 1 172 ? 37.912  -19.537 -12.580 1.00 52.26  ? 136 ARG A HB3  1 
ATOM   2126 H HG2  . ARG A 1 172 ? 38.205  -21.661 -11.247 1.00 49.00  ? 136 ARG A HG2  1 
ATOM   2127 H HG3  . ARG A 1 172 ? 36.841  -21.159 -10.603 1.00 49.00  ? 136 ARG A HG3  1 
ATOM   2128 H HD2  . ARG A 1 172 ? 36.527  -22.598 -12.482 1.00 49.14  ? 136 ARG A HD2  1 
ATOM   2129 H HD3  . ARG A 1 172 ? 35.797  -21.195 -12.639 1.00 49.14  ? 136 ARG A HD3  1 
ATOM   2130 H HE   . ARG A 1 172 ? 38.137  -21.011 -13.784 1.00 57.94  ? 136 ARG A HE   1 
ATOM   2131 H HH11 . ARG A 1 172 ? 35.306  -22.605 -14.475 1.00 58.68  ? 136 ARG A HH11 1 
ATOM   2132 H HH12 . ARG A 1 172 ? 35.505  -22.632 -15.951 1.00 58.68  ? 136 ARG A HH12 1 
ATOM   2133 H HH21 . ARG A 1 172 ? 38.389  -21.027 -16.014 1.00 59.31  ? 136 ARG A HH21 1 
ATOM   2134 H HH22 . ARG A 1 172 ? 37.368  -21.678 -16.882 1.00 59.31  ? 136 ARG A HH22 1 
ATOM   2135 N N    . ASN A 1 173 ? 40.269  -17.239 -10.246 1.00 30.82  ? 137 ASN A N    1 
ATOM   2136 C CA   . ASN A 1 173 ? 40.647  -15.832 -10.246 1.00 31.92  ? 137 ASN A CA   1 
ATOM   2137 C C    . ASN A 1 173 ? 39.578  -14.934 -9.643  1.00 26.71  ? 137 ASN A C    1 
ATOM   2138 O O    . ASN A 1 173 ? 39.616  -13.713 -9.840  1.00 28.36  ? 137 ASN A O    1 
ATOM   2139 C CB   . ASN A 1 173 ? 40.969  -15.346 -11.657 1.00 37.17  ? 137 ASN A CB   1 
ATOM   2140 C CG   . ASN A 1 173 ? 42.011  -16.197 -12.327 1.00 47.14  ? 137 ASN A CG   1 
ATOM   2141 O OD1  . ASN A 1 173 ? 43.104  -16.402 -11.787 1.00 42.54  ? 137 ASN A OD1  1 
ATOM   2142 N ND2  . ASN A 1 173 ? 41.675  -16.724 -13.497 1.00 53.06  ? 137 ASN A ND2  1 
ATOM   2143 H H    . ASN A 1 173 ? 40.712  -17.705 -9.676  1.00 36.98  ? 137 ASN A H    1 
ATOM   2144 H HA   . ASN A 1 173 ? 41.444  -15.744 -9.700  1.00 38.29  ? 137 ASN A HA   1 
ATOM   2145 H HB2  . ASN A 1 173 ? 40.163  -15.375 -12.196 1.00 44.59  ? 137 ASN A HB2  1 
ATOM   2146 H HB3  . ASN A 1 173 ? 41.305  -14.437 -11.612 1.00 44.59  ? 137 ASN A HB3  1 
ATOM   2147 H HD21 . ASN A 1 173 ? 40.897  -16.571 -13.830 1.00 63.66  ? 137 ASN A HD21 1 
ATOM   2148 H HD22 . ASN A 1 173 ? 42.234  -17.220 -13.923 1.00 63.66  ? 137 ASN A HD22 1 
ATOM   2149 N N    . VAL A 1 174 ? 38.617  -15.512 -8.933  1.00 27.37  ? 138 VAL A N    1 
ATOM   2150 C CA   . VAL A 1 174 ? 37.660  -14.749 -8.140  1.00 26.37  ? 138 VAL A CA   1 
ATOM   2151 C C    . VAL A 1 174 ? 38.163  -14.753 -6.705  1.00 22.24  ? 138 VAL A C    1 
ATOM   2152 O O    . VAL A 1 174 ? 38.412  -15.816 -6.134  1.00 24.64  ? 138 VAL A O    1 
ATOM   2153 C CB   . VAL A 1 174 ? 36.245  -15.340 -8.237  1.00 28.19  ? 138 VAL A CB   1 
ATOM   2154 C CG1  . VAL A 1 174 ? 35.309  -14.658 -7.237  1.00 23.35  ? 138 VAL A CG1  1 
ATOM   2155 C CG2  . VAL A 1 174 ? 35.727  -15.192 -9.644  1.00 30.97  ? 138 VAL A CG2  1 
ATOM   2156 H H    . VAL A 1 174 ? 38.496  -16.363 -8.895  1.00 32.83  ? 138 VAL A H    1 
ATOM   2157 H HA   . VAL A 1 174 ? 37.622  -13.833 -8.459  1.00 31.63  ? 138 VAL A HA   1 
ATOM   2158 H HB   . VAL A 1 174 ? 36.274  -16.285 -8.017  1.00 33.82  ? 138 VAL A HB   1 
ATOM   2159 H HG11 . VAL A 1 174 ? 34.391  -14.812 -7.507  1.00 28.01  ? 138 VAL A HG11 1 
ATOM   2160 H HG12 . VAL A 1 174 ? 35.462  -15.032 -6.355  1.00 28.01  ? 138 VAL A HG12 1 
ATOM   2161 H HG13 . VAL A 1 174 ? 35.496  -13.706 -7.229  1.00 28.01  ? 138 VAL A HG13 1 
ATOM   2162 H HG21 . VAL A 1 174 ? 34.857  -15.616 -9.707  1.00 37.15  ? 138 VAL A HG21 1 
ATOM   2163 H HG22 . VAL A 1 174 ? 35.651  -14.249 -9.855  1.00 37.15  ? 138 VAL A HG22 1 
ATOM   2164 H HG23 . VAL A 1 174 ? 36.347  -15.619 -10.256 1.00 37.15  ? 138 VAL A HG23 1 
ATOM   2165 N N    . PHE A 1 175 ? 38.386  -13.570 -6.145  1.00 21.88  ? 139 PHE A N    1 
ATOM   2166 C CA   . PHE A 1 175 ? 39.041  -13.457 -4.856  1.00 18.62  ? 139 PHE A CA   1 
ATOM   2167 C C    . PHE A 1 175 ? 38.052  -13.601 -3.708  1.00 19.39  ? 139 PHE A C    1 
ATOM   2168 O O    . PHE A 1 175 ? 36.828  -13.683 -3.900  1.00 18.38  ? 139 PHE A O    1 
ATOM   2169 C CB   . PHE A 1 175 ? 39.794  -12.129 -4.797  1.00 23.31  ? 139 PHE A CB   1 
ATOM   2170 C CG   . PHE A 1 175 ? 40.725  -11.918 -5.968  1.00 23.17  ? 139 PHE A CG   1 
ATOM   2171 C CD1  . PHE A 1 175 ? 41.698  -12.869 -6.258  1.00 31.57  ? 139 PHE A CD1  1 
ATOM   2172 C CD2  . PHE A 1 175 ? 40.596  -10.820 -6.801  1.00 28.05  ? 139 PHE A CD2  1 
ATOM   2173 C CE1  . PHE A 1 175 ? 42.544  -12.705 -7.318  1.00 28.44  ? 139 PHE A CE1  1 
ATOM   2174 C CE2  . PHE A 1 175 ? 41.453  -10.638 -7.890  1.00 29.68  ? 139 PHE A CE2  1 
ATOM   2175 C CZ   . PHE A 1 175 ? 42.430  -11.598 -8.144  1.00 33.63  ? 139 PHE A CZ   1 
ATOM   2176 H H    . PHE A 1 175 ? 38.164  -12.816 -6.497  1.00 26.25  ? 139 PHE A H    1 
ATOM   2177 H HA   . PHE A 1 175 ? 39.679  -14.179 -4.748  1.00 22.33  ? 139 PHE A HA   1 
ATOM   2178 H HB2  . PHE A 1 175 ? 39.150  -11.403 -4.793  1.00 27.96  ? 139 PHE A HB2  1 
ATOM   2179 H HB3  . PHE A 1 175 ? 40.325  -12.105 -3.985  1.00 27.96  ? 139 PHE A HB3  1 
ATOM   2180 H HD1  . PHE A 1 175 ? 41.774  -13.626 -5.723  1.00 37.87  ? 139 PHE A HD1  1 
ATOM   2181 H HD2  . PHE A 1 175 ? 39.929  -10.195 -6.634  1.00 33.65  ? 139 PHE A HD2  1 
ATOM   2182 H HE1  . PHE A 1 175 ? 43.201  -13.341 -7.486  1.00 34.12  ? 139 PHE A HE1  1 
ATOM   2183 H HE2  . PHE A 1 175 ? 41.373  -9.889  -8.436  1.00 35.61  ? 139 PHE A HE2  1 
ATOM   2184 H HZ   . PHE A 1 175 ? 43.006  -11.497 -8.867  1.00 40.35  ? 139 PHE A HZ   1 
ATOM   2185 N N    . PHE A 1 176 ? 38.606  -13.700 -2.505  1.00 17.57  ? 140 PHE A N    1 
ATOM   2186 C CA   . PHE A 1 176 ? 37.868  -14.073 -1.310  1.00 20.10  ? 140 PHE A CA   1 
ATOM   2187 C C    . PHE A 1 176 ? 37.930  -12.920 -0.332  1.00 22.30  ? 140 PHE A C    1 
ATOM   2188 O O    . PHE A 1 176 ? 39.016  -12.597 0.156   1.00 17.85  ? 140 PHE A O    1 
ATOM   2189 C CB   . PHE A 1 176 ? 38.463  -15.302 -0.593  1.00 22.39  ? 140 PHE A CB   1 
ATOM   2190 C CG   . PHE A 1 176 ? 38.519  -16.572 -1.416  1.00 23.84  ? 140 PHE A CG   1 
ATOM   2191 C CD1  . PHE A 1 176 ? 37.857  -16.704 -2.623  1.00 26.86  ? 140 PHE A CD1  1 
ATOM   2192 C CD2  . PHE A 1 176 ? 39.250  -17.652 -0.936  1.00 23.16  ? 140 PHE A CD2  1 
ATOM   2193 C CE1  . PHE A 1 176 ? 37.944  -17.894 -3.341  1.00 26.17  ? 140 PHE A CE1  1 
ATOM   2194 C CE2  . PHE A 1 176 ? 39.324  -18.841 -1.624  1.00 26.15  ? 140 PHE A CE2  1 
ATOM   2195 C CZ   . PHE A 1 176 ? 38.685  -18.962 -2.840  1.00 24.91  ? 140 PHE A CZ   1 
ATOM   2196 H H    . PHE A 1 176 ? 39.439  -13.550 -2.353  1.00 21.07  ? 140 PHE A H    1 
ATOM   2197 H HA   . PHE A 1 176 ? 36.958  -14.267 -1.583  1.00 24.11  ? 140 PHE A HA   1 
ATOM   2198 H HB2  . PHE A 1 176 ? 39.371  -15.090 -0.327  1.00 26.85  ? 140 PHE A HB2  1 
ATOM   2199 H HB3  . PHE A 1 176 ? 37.923  -15.489 0.191   1.00 26.85  ? 140 PHE A HB3  1 
ATOM   2200 H HD1  . PHE A 1 176 ? 37.352  -15.996 -2.955  1.00 32.22  ? 140 PHE A HD1  1 
ATOM   2201 H HD2  . PHE A 1 176 ? 39.702  -17.568 -0.127  1.00 27.78  ? 140 PHE A HD2  1 
ATOM   2202 H HE1  . PHE A 1 176 ? 37.506  -17.976 -4.157  1.00 31.39  ? 140 PHE A HE1  1 
ATOM   2203 H HE2  . PHE A 1 176 ? 39.801  -19.558 -1.272  1.00 31.37  ? 140 PHE A HE2  1 
ATOM   2204 H HZ   . PHE A 1 176 ? 38.749  -19.753 -3.324  1.00 29.89  ? 140 PHE A HZ   1 
ATOM   2205 N N    . PHE A 1 177 ? 36.773  -12.338 -0.002  1.00 19.39  ? 141 PHE A N    1 
ATOM   2206 C CA   . PHE A 1 177 ? 36.720  -11.357 1.071   1.00 18.35  ? 141 PHE A CA   1 
ATOM   2207 C C    . PHE A 1 177 ? 37.143  -12.009 2.384   1.00 18.53  ? 141 PHE A C    1 
ATOM   2208 O O    . PHE A 1 177 ? 36.847  -13.180 2.646   1.00 19.54  ? 141 PHE A O    1 
ATOM   2209 C CB   . PHE A 1 177 ? 35.304  -10.783 1.206   1.00 15.95  ? 141 PHE A CB   1 
ATOM   2210 C CG   . PHE A 1 177 ? 34.833  -9.998  -0.002  1.00 17.66  ? 141 PHE A CG   1 
ATOM   2211 C CD1  . PHE A 1 177 ? 35.575  -8.939  -0.510  1.00 19.14  ? 141 PHE A CD1  1 
ATOM   2212 C CD2  . PHE A 1 177 ? 33.593  -10.266 -0.563  1.00 15.94  ? 141 PHE A CD2  1 
ATOM   2213 C CE1  . PHE A 1 177 ? 35.126  -8.209  -1.594  1.00 18.84  ? 141 PHE A CE1  1 
ATOM   2214 C CE2  . PHE A 1 177 ? 33.148  -9.560  -1.657  1.00 17.44  ? 141 PHE A CE2  1 
ATOM   2215 C CZ   . PHE A 1 177 ? 33.884  -8.487  -2.150  1.00 18.52  ? 141 PHE A CZ   1 
ATOM   2216 H H    . PHE A 1 177 ? 36.018  -12.495 -0.382  1.00 23.26  ? 141 PHE A H    1 
ATOM   2217 H HA   . PHE A 1 177 ? 37.322  -10.623 0.872   1.00 22.01  ? 141 PHE A HA   1 
ATOM   2218 H HB2  . PHE A 1 177 ? 34.684  -11.517 1.340   1.00 19.13  ? 141 PHE A HB2  1 
ATOM   2219 H HB3  . PHE A 1 177 ? 35.283  -10.186 1.971   1.00 19.13  ? 141 PHE A HB3  1 
ATOM   2220 H HD1  . PHE A 1 177 ? 36.387  -8.718  -0.114  1.00 22.96  ? 141 PHE A HD1  1 
ATOM   2221 H HD2  . PHE A 1 177 ? 33.057  -10.930 -0.195  1.00 19.12  ? 141 PHE A HD2  1 
ATOM   2222 H HE1  . PHE A 1 177 ? 35.656  -7.533  -1.951  1.00 22.60  ? 141 PHE A HE1  1 
ATOM   2223 H HE2  . PHE A 1 177 ? 32.350  -9.802  -2.070  1.00 20.92  ? 141 PHE A HE2  1 
ATOM   2224 H HZ   . PHE A 1 177 ? 33.549  -7.963  -2.841  1.00 22.22  ? 141 PHE A HZ   1 
ATOM   2225 N N    . ASP A 1 178 ? 37.837  -11.238 3.213   1.00 17.72  ? 142 ASP A N    1 
ATOM   2226 C CA   . ASP A 1 178 ? 38.255  -11.649 4.549   1.00 16.57  ? 142 ASP A CA   1 
ATOM   2227 C C    . ASP A 1 178 ? 37.426  -10.961 5.622   1.00 21.99  ? 142 ASP A C    1 
ATOM   2228 O O    . ASP A 1 178 ? 37.683  -9.808  5.990   1.00 19.55  ? 142 ASP A O    1 
ATOM   2229 C CB   . ASP A 1 178 ? 39.751  -11.358 4.763   1.00 19.19  ? 142 ASP A CB   1 
ATOM   2230 C CG   . ASP A 1 178 ? 40.233  -11.797 6.114   1.00 25.38  ? 142 ASP A CG   1 
ATOM   2231 O OD1  . ASP A 1 178 ? 39.486  -12.483 6.805   1.00 19.74  ? 142 ASP A OD1  1 
ATOM   2232 O OD2  . ASP A 1 178 ? 41.393  -11.483 6.477   1.00 23.88  ? 142 ASP A OD2  1 
ATOM   2233 H H    . ASP A 1 178 ? 38.088  -10.439 3.016   1.00 21.25  ? 142 ASP A H    1 
ATOM   2234 H HA   . ASP A 1 178 ? 38.079  -12.600 4.620   1.00 19.88  ? 142 ASP A HA   1 
ATOM   2235 H HB2  . ASP A 1 178 ? 40.265  -11.832 4.091   1.00 23.02  ? 142 ASP A HB2  1 
ATOM   2236 H HB3  . ASP A 1 178 ? 39.902  -10.403 4.685   1.00 23.02  ? 142 ASP A HB3  1 
ATOM   2237 N N    . VAL A 1 179 ? 36.433  -11.690 6.136   1.00 18.89  ? 143 VAL A N    1 
ATOM   2238 C CA   . VAL A 1 179 ? 35.549  -11.139 7.155   1.00 16.76  ? 143 VAL A CA   1 
ATOM   2239 C C    . VAL A 1 179 ? 36.270  -10.861 8.461   1.00 22.70  ? 143 VAL A C    1 
ATOM   2240 O O    . VAL A 1 179 ? 35.776  -10.084 9.279   1.00 21.15  ? 143 VAL A O    1 
ATOM   2241 C CB   . VAL A 1 179 ? 34.355  -12.099 7.359   1.00 16.88  ? 143 VAL A CB   1 
ATOM   2242 C CG1  . VAL A 1 179 ? 34.753  -13.338 8.172   1.00 22.61  ? 143 VAL A CG1  1 
ATOM   2243 C CG2  . VAL A 1 179 ? 33.166  -11.369 7.993   1.00 24.00  ? 143 VAL A CG2  1 
ATOM   2244 H H    . VAL A 1 179 ? 36.254  -12.501 5.912   1.00 22.65  ? 143 VAL A H    1 
ATOM   2245 H HA   . VAL A 1 179 ? 35.212  -10.283 6.848   1.00 20.10  ? 143 VAL A HA   1 
ATOM   2246 H HB   . VAL A 1 179 ? 34.075  -12.415 6.486   1.00 20.25  ? 143 VAL A HB   1 
ATOM   2247 H HG11 . VAL A 1 179 ? 34.055  -14.006 8.090   1.00 27.12  ? 143 VAL A HG11 1 
ATOM   2248 H HG12 . VAL A 1 179 ? 35.588  -13.688 7.826   1.00 27.12  ? 143 VAL A HG12 1 
ATOM   2249 H HG13 . VAL A 1 179 ? 34.860  -13.084 9.102   1.00 27.12  ? 143 VAL A HG13 1 
ATOM   2250 H HG21 . VAL A 1 179 ? 32.394  -11.957 7.984   1.00 28.79  ? 143 VAL A HG21 1 
ATOM   2251 H HG22 . VAL A 1 179 ? 33.392  -11.132 8.906   1.00 28.79  ? 143 VAL A HG22 1 
ATOM   2252 H HG23 . VAL A 1 179 ? 32.978  -10.568 7.480   1.00 28.79  ? 143 VAL A HG23 1 
ATOM   2253 N N    . LEU A 1 180 ? 37.443  -11.454 8.680   1.00 20.41  ? 144 LEU A N    1 
ATOM   2254 C CA   . LEU A 1 180 ? 38.178  -11.132 9.893   1.00 21.88  ? 144 LEU A CA   1 
ATOM   2255 C C    . LEU A 1 180 ? 38.815  -9.754  9.816   1.00 24.18  ? 144 LEU A C    1 
ATOM   2256 O O    . LEU A 1 180 ? 39.276  -9.243  10.840  1.00 26.86  ? 144 LEU A O    1 
ATOM   2257 C CB   . LEU A 1 180 ? 39.251  -12.185 10.144  1.00 22.77  ? 144 LEU A CB   1 
ATOM   2258 C CG   . LEU A 1 180 ? 38.720  -13.577 10.501  1.00 22.49  ? 144 LEU A CG   1 
ATOM   2259 C CD1  . LEU A 1 180 ? 39.882  -14.485 10.853  1.00 27.49  ? 144 LEU A CD1  1 
ATOM   2260 C CD2  . LEU A 1 180 ? 37.737  -13.505 11.599  1.00 25.65  ? 144 LEU A CD2  1 
ATOM   2261 H H    . LEU A 1 180 ? 37.819  -12.025 8.158   1.00 24.48  ? 144 LEU A H    1 
ATOM   2262 H HA   . LEU A 1 180 ? 37.573  -11.145 10.651  1.00 26.25  ? 144 LEU A HA   1 
ATOM   2263 H HB2  . LEU A 1 180 ? 39.786  -12.275 9.339   1.00 27.32  ? 144 LEU A HB2  1 
ATOM   2264 H HB3  . LEU A 1 180 ? 39.807  -11.887 10.880  1.00 27.32  ? 144 LEU A HB3  1 
ATOM   2265 H HG   . LEU A 1 180 ? 38.255  -13.955 9.739   1.00 26.98  ? 144 LEU A HG   1 
ATOM   2266 H HD11 . LEU A 1 180 ? 39.539  -15.361 11.087  1.00 32.97  ? 144 LEU A HD11 1 
ATOM   2267 H HD12 . LEU A 1 180 ? 40.471  -14.555 10.085  1.00 32.97  ? 144 LEU A HD12 1 
ATOM   2268 H HD13 . LEU A 1 180 ? 40.363  -14.106 11.605  1.00 32.97  ? 144 LEU A HD13 1 
ATOM   2269 H HD21 . LEU A 1 180 ? 37.659  -14.379 12.010  1.00 30.76  ? 144 LEU A HD21 1 
ATOM   2270 H HD22 . LEU A 1 180 ? 38.042  -12.857 12.253  1.00 30.76  ? 144 LEU A HD22 1 
ATOM   2271 H HD23 . LEU A 1 180 ? 36.880  -13.231 11.238  1.00 30.76  ? 144 LEU A HD23 1 
ATOM   2272 N N    . ASN A 1 181 ? 38.831  -9.147  8.635   1.00 21.26  ? 145 ASN A N    1 
ATOM   2273 C CA   . ASN A 1 181 ? 39.446  -7.843  8.436   1.00 20.85  ? 145 ASN A CA   1 
ATOM   2274 C C    . ASN A 1 181 ? 38.390  -6.790  8.733   1.00 22.64  ? 145 ASN A C    1 
ATOM   2275 O O    . ASN A 1 181 ? 37.410  -6.682  7.972   1.00 18.86  ? 145 ASN A O    1 
ATOM   2276 C CB   . ASN A 1 181 ? 39.951  -7.718  7.003   1.00 18.31  ? 145 ASN A CB   1 
ATOM   2277 C CG   . ASN A 1 181 ? 40.670  -6.413  6.740   1.00 21.75  ? 145 ASN A CG   1 
ATOM   2278 O OD1  . ASN A 1 181 ? 40.359  -5.389  7.338   1.00 22.43  ? 145 ASN A OD1  1 
ATOM   2279 N ND2  . ASN A 1 181 ? 41.615  -6.441  5.812   1.00 24.52  ? 145 ASN A ND2  1 
ATOM   2280 H H    . ASN A 1 181 ? 38.486  -9.477  7.920   1.00 25.50  ? 145 ASN A H    1 
ATOM   2281 H HA   . ASN A 1 181 ? 40.198  -7.715  9.036   1.00 25.01  ? 145 ASN A HA   1 
ATOM   2282 H HB2  . ASN A 1 181 ? 40.571  -8.443  6.823   1.00 21.96  ? 145 ASN A HB2  1 
ATOM   2283 H HB3  . ASN A 1 181 ? 39.195  -7.770  6.397   1.00 21.96  ? 145 ASN A HB3  1 
ATOM   2284 H HD21 . ASN A 1 181 ? 42.054  -5.725  5.624   1.00 29.41  ? 145 ASN A HD21 1 
ATOM   2285 H HD22 . ASN A 1 181 ? 41.789  -7.174  5.397   1.00 29.41  ? 145 ASN A HD22 1 
ATOM   2286 N N    . PRO A 1 182 ? 38.514  -6.023  9.825   1.00 22.95  ? 146 PRO A N    1 
ATOM   2287 C CA   . PRO A 1 182 ? 37.462  -5.041  10.137  1.00 24.20  ? 146 PRO A CA   1 
ATOM   2288 C C    . PRO A 1 182 ? 37.248  -4.008  9.055   1.00 22.50  ? 146 PRO A C    1 
ATOM   2289 O O    . PRO A 1 182 ? 36.119  -3.505  8.937   1.00 20.69  ? 146 PRO A O    1 
ATOM   2290 C CB   . PRO A 1 182 ? 37.938  -4.391  11.447  1.00 24.24  ? 146 PRO A CB   1 
ATOM   2291 C CG   . PRO A 1 182 ? 39.348  -4.850  11.640  1.00 31.83  ? 146 PRO A CG   1 
ATOM   2292 C CD   . PRO A 1 182 ? 39.531  -6.115  10.896  1.00 22.17  ? 146 PRO A CD   1 
ATOM   2293 H HA   . PRO A 1 182 ? 36.629  -5.511  10.301  1.00 29.03  ? 146 PRO A HA   1 
ATOM   2294 H HB2  . PRO A 1 182 ? 37.899  -3.425  11.366  1.00 29.08  ? 146 PRO A HB2  1 
ATOM   2295 H HB3  . PRO A 1 182 ? 37.377  -4.685  12.181  1.00 29.08  ? 146 PRO A HB3  1 
ATOM   2296 H HG2  . PRO A 1 182 ? 39.952  -4.172  11.299  1.00 38.18  ? 146 PRO A HG2  1 
ATOM   2297 H HG3  . PRO A 1 182 ? 39.509  -4.993  12.585  1.00 38.18  ? 146 PRO A HG3  1 
ATOM   2298 H HD2  . PRO A 1 182 ? 40.424  -6.171  10.521  1.00 26.60  ? 146 PRO A HD2  1 
ATOM   2299 H HD3  . PRO A 1 182 ? 39.362  -6.880  11.468  1.00 26.60  ? 146 PRO A HD3  1 
ATOM   2300 N N    . GLU A 1 183 ? 38.287  -3.647  8.281   1.00 20.44  ? 147 GLU A N    1 
ATOM   2301 C CA   . GLU A 1 183 ? 38.107  -2.675  7.198   1.00 21.36  ? 147 GLU A CA   1 
ATOM   2302 C C    . GLU A 1 183 ? 37.279  -3.271  6.064   1.00 22.70  ? 147 GLU A C    1 
ATOM   2303 O O    . GLU A 1 183 ? 36.520  -2.557  5.398   1.00 19.14  ? 147 GLU A O    1 
ATOM   2304 C CB   . GLU A 1 183 ? 39.474  -2.188  6.672   1.00 24.56  ? 147 GLU A CB   1 
ATOM   2305 C CG   . GLU A 1 183 ? 40.332  -1.609  7.782   1.00 26.63  ? 147 GLU A CG   1 
ATOM   2306 C CD   . GLU A 1 183 ? 41.544  -0.871  7.274   1.00 32.69  ? 147 GLU A CD   1 
ATOM   2307 O OE1  . GLU A 1 183 ? 41.922  -1.100  6.113   1.00 29.49  ? 147 GLU A OE1  1 
ATOM   2308 O OE2  . GLU A 1 183 ? 42.096  -0.039  8.027   1.00 45.31  ? 147 GLU A OE2  1 
ATOM   2309 H H    . GLU A 1 183 ? 39.089  -3.947  8.363   1.00 24.52  ? 147 GLU A H    1 
ATOM   2310 H HA   . GLU A 1 183 ? 37.641  -1.898  7.546   1.00 25.62  ? 147 GLU A HA   1 
ATOM   2311 H HB2  . GLU A 1 183 ? 39.949  -2.937  6.279   1.00 29.46  ? 147 GLU A HB2  1 
ATOM   2312 H HB3  . GLU A 1 183 ? 39.332  -1.498  6.005   1.00 29.46  ? 147 GLU A HB3  1 
ATOM   2313 H HG2  . GLU A 1 183 ? 39.798  -0.986  8.299   1.00 31.94  ? 147 GLU A HG2  1 
ATOM   2314 H HG3  . GLU A 1 183 ? 40.640  -2.332  8.351   1.00 31.94  ? 147 GLU A HG3  1 
ATOM   2315 N N    . LEU A 1 184 ? 37.401  -4.584  5.858   1.00 18.68  ? 148 LEU A N    1 
ATOM   2316 C CA   . LEU A 1 184 ? 36.552  -5.268  4.900   1.00 18.17  ? 148 LEU A CA   1 
ATOM   2317 C C    . LEU A 1 184 ? 35.119  -5.265  5.388   1.00 15.98  ? 148 LEU A C    1 
ATOM   2318 O O    . LEU A 1 184 ? 34.198  -4.991  4.618   1.00 15.83  ? 148 LEU A O    1 
ATOM   2319 C CB   . LEU A 1 184 ? 37.028  -6.702  4.689   1.00 16.07  ? 148 LEU A CB   1 
ATOM   2320 C CG   . LEU A 1 184 ? 36.267  -7.602  3.714   1.00 17.09  ? 148 LEU A CG   1 
ATOM   2321 C CD1  . LEU A 1 184 ? 35.107  -8.296  4.429   1.00 19.81  ? 148 LEU A CD1  1 
ATOM   2322 C CD2  . LEU A 1 184 ? 35.781  -6.874  2.511   1.00 15.16  ? 148 LEU A CD2  1 
ATOM   2323 H H    . LEU A 1 184 ? 37.966  -5.093  6.260   1.00 22.40  ? 148 LEU A H    1 
ATOM   2324 H HA   . LEU A 1 184 ? 36.605  -4.812  4.046   1.00 21.79  ? 148 LEU A HA   1 
ATOM   2325 H HB2  . LEU A 1 184 ? 37.942  -6.660  4.366   1.00 19.27  ? 148 LEU A HB2  1 
ATOM   2326 H HB3  . LEU A 1 184 ? 37.001  -7.148  5.550   1.00 19.27  ? 148 LEU A HB3  1 
ATOM   2327 H HG   . LEU A 1 184 ? 36.889  -8.273  3.391   1.00 20.50  ? 148 LEU A HG   1 
ATOM   2328 H HD11 . LEU A 1 184 ? 34.772  -9.010  3.866   1.00 23.76  ? 148 LEU A HD11 1 
ATOM   2329 H HD12 . LEU A 1 184 ? 35.426  -8.659  5.270   1.00 23.76  ? 148 LEU A HD12 1 
ATOM   2330 H HD13 . LEU A 1 184 ? 34.405  -7.647  4.594   1.00 23.76  ? 148 LEU A HD13 1 
ATOM   2331 H HD21 . LEU A 1 184 ? 35.427  -7.516  1.876   1.00 18.18  ? 148 LEU A HD21 1 
ATOM   2332 H HD22 . LEU A 1 184 ? 35.084  -6.254  2.777   1.00 18.18  ? 148 LEU A HD22 1 
ATOM   2333 H HD23 . LEU A 1 184 ? 36.521  -6.390  2.115   1.00 18.18  ? 148 LEU A HD23 1 
ATOM   2334 N N    . ARG A 1 185 ? 34.921  -5.541  6.678   1.00 17.32  ? 149 ARG A N    1 
ATOM   2335 C CA   . ARG A 1 185 ? 33.557  -5.586  7.201   1.00 17.79  ? 149 ARG A CA   1 
ATOM   2336 C C    . ARG A 1 185 ? 32.877  -4.257  6.974   1.00 15.10  ? 149 ARG A C    1 
ATOM   2337 O O    . ARG A 1 185 ? 31.715  -4.206  6.558   1.00 16.64  ? 149 ARG A O    1 
ATOM   2338 C CB   . ARG A 1 185 ? 33.567  -5.960  8.683   1.00 16.69  ? 149 ARG A CB   1 
ATOM   2339 C CG   . ARG A 1 185 ? 34.018  -7.380  8.922   1.00 18.54  ? 149 ARG A CG   1 
ATOM   2340 C CD   . ARG A 1 185 ? 33.603  -7.933  10.279  1.00 19.52  ? 149 ARG A CD   1 
ATOM   2341 N NE   . ARG A 1 185 ? 34.147  -7.170  11.395  1.00 23.07  ? 149 ARG A NE   1 
ATOM   2342 C CZ   . ARG A 1 185 ? 35.332  -7.370  11.955  1.00 21.85  ? 149 ARG A CZ   1 
ATOM   2343 N NH1  . ARG A 1 185 ? 36.166  -8.303  11.515  1.00 19.98  ? 149 ARG A NH1  1 
ATOM   2344 N NH2  . ARG A 1 185 ? 35.683  -6.632  12.999  1.00 24.63  ? 149 ARG A NH2  1 
ATOM   2345 H H    . ARG A 1 185 ? 35.539  -5.701  7.254   1.00 20.77  ? 149 ARG A H    1 
ATOM   2346 H HA   . ARG A 1 185 ? 33.051  -6.275  6.742   1.00 21.34  ? 149 ARG A HA   1 
ATOM   2347 H HB2  . ARG A 1 185 ? 34.174  -5.368  9.154   1.00 20.01  ? 149 ARG A HB2  1 
ATOM   2348 H HB3  . ARG A 1 185 ? 32.669  -5.865  9.038   1.00 20.01  ? 149 ARG A HB3  1 
ATOM   2349 H HG2  . ARG A 1 185 ? 33.632  -7.951  8.239   1.00 22.24  ? 149 ARG A HG2  1 
ATOM   2350 H HG3  . ARG A 1 185 ? 34.986  -7.413  8.873   1.00 22.24  ? 149 ARG A HG3  1 
ATOM   2351 H HD2  . ARG A 1 185 ? 32.636  -7.911  10.345  1.00 23.42  ? 149 ARG A HD2  1 
ATOM   2352 H HD3  . ARG A 1 185 ? 33.921  -8.846  10.358  1.00 23.42  ? 149 ARG A HD3  1 
ATOM   2353 H HE   . ARG A 1 185 ? 33.660  -6.539  11.717  1.00 27.67  ? 149 ARG A HE   1 
ATOM   2354 H HH11 . ARG A 1 185 ? 35.943  -8.798  10.848  1.00 23.96  ? 149 ARG A HH11 1 
ATOM   2355 H HH12 . ARG A 1 185 ? 36.929  -8.412  11.896  1.00 23.96  ? 149 ARG A HH12 1 
ATOM   2356 H HH21 . ARG A 1 185 ? 35.145  -6.034  13.303  1.00 29.54  ? 149 ARG A HH21 1 
ATOM   2357 H HH22 . ARG A 1 185 ? 36.449  -6.751  13.372  1.00 29.54  ? 149 ARG A HH22 1 
ATOM   2358 N N    . GLU A 1 186 ? 33.630  -3.165  7.155   1.00 16.25  ? 150 GLU A N    1 
ATOM   2359 C CA   . GLU A 1 186 ? 33.084  -1.833  6.975   1.00 15.80  ? 150 GLU A CA   1 
ATOM   2360 C C    . GLU A 1 186 ? 32.830  -1.544  5.498   1.00 17.68  ? 150 GLU A C    1 
ATOM   2361 O O    . GLU A 1 186 ? 31.751  -1.056  5.118   1.00 19.42  ? 150 GLU A O    1 
ATOM   2362 C CB   . GLU A 1 186 ? 34.069  -0.815  7.578   1.00 19.47  ? 150 GLU A CB   1 
ATOM   2363 C CG   . GLU A 1 186 ? 33.751  0.608   7.260   1.00 25.29  ? 150 GLU A CG   1 
ATOM   2364 C CD   . GLU A 1 186 ? 32.448  1.076   7.906   1.00 31.11  ? 150 GLU A CD   1 
ATOM   2365 O OE1  . GLU A 1 186 ? 31.947  0.384   8.836   1.00 22.23  ? 150 GLU A OE1  1 
ATOM   2366 O OE2  . GLU A 1 186 ? 31.954  2.151   7.469   1.00 33.33  ? 150 GLU A OE2  1 
ATOM   2367 H H    . GLU A 1 186 ? 34.460  -3.177  7.382   1.00 19.48  ? 150 GLU A H    1 
ATOM   2368 H HA   . GLU A 1 186 ? 32.234  -1.755  7.435   1.00 18.95  ? 150 GLU A HA   1 
ATOM   2369 H HB2  . GLU A 1 186 ? 34.060  -0.910  8.544   1.00 23.36  ? 150 GLU A HB2  1 
ATOM   2370 H HB3  . GLU A 1 186 ? 34.957  -1.002  7.235   1.00 23.36  ? 150 GLU A HB3  1 
ATOM   2371 H HG2  . GLU A 1 186 ? 34.469  1.173   7.586   1.00 30.33  ? 150 GLU A HG2  1 
ATOM   2372 H HG3  . GLU A 1 186 ? 33.663  0.705   6.299   1.00 30.33  ? 150 GLU A HG3  1 
ATOM   2373 N N    . TRP A 1 187 ? 33.819  -1.832  4.648   1.00 14.47  ? 151 TRP A N    1 
ATOM   2374 C CA   . TRP A 1 187 ? 33.678  -1.573  3.219   1.00 14.24  ? 151 TRP A CA   1 
ATOM   2375 C C    . TRP A 1 187 ? 32.523  -2.364  2.632   1.00 16.21  ? 151 TRP A C    1 
ATOM   2376 O O    . TRP A 1 187 ? 31.703  -1.846  1.865   1.00 15.69  ? 151 TRP A O    1 
ATOM   2377 C CB   . TRP A 1 187 ? 34.964  -1.931  2.468   1.00 18.07  ? 151 TRP A CB   1 
ATOM   2378 C CG   . TRP A 1 187 ? 34.822  -1.742  1.028   1.00 14.45  ? 151 TRP A CG   1 
ATOM   2379 C CD1  . TRP A 1 187 ? 35.026  -0.585  0.349   1.00 20.56  ? 151 TRP A CD1  1 
ATOM   2380 C CD2  . TRP A 1 187 ? 34.462  -2.714  0.064   1.00 15.25  ? 151 TRP A CD2  1 
ATOM   2381 N NE1  . TRP A 1 187 ? 34.790  -0.771  -0.990  1.00 21.92  ? 151 TRP A NE1  1 
ATOM   2382 C CE2  . TRP A 1 187 ? 34.455  -2.082  -1.187  1.00 17.24  ? 151 TRP A CE2  1 
ATOM   2383 C CE3  . TRP A 1 187 ? 34.134  -4.077  0.132   1.00 18.58  ? 151 TRP A CE3  1 
ATOM   2384 C CZ2  . TRP A 1 187 ? 34.125  -2.746  -2.349  1.00 16.64  ? 151 TRP A CZ2  1 
ATOM   2385 C CZ3  . TRP A 1 187 ? 33.825  -4.731  -1.037  1.00 16.80  ? 151 TRP A CZ3  1 
ATOM   2386 C CH2  . TRP A 1 187 ? 33.802  -4.074  -2.244  1.00 16.61  ? 151 TRP A CH2  1 
ATOM   2387 H H    . TRP A 1 187 ? 34.574  -2.175  4.874   1.00 17.36  ? 151 TRP A H    1 
ATOM   2388 H HA   . TRP A 1 187 ? 33.510  -0.624  3.107   1.00 17.07  ? 151 TRP A HA   1 
ATOM   2389 H HB2  . TRP A 1 187 ? 35.685  -1.363  2.781   1.00 21.68  ? 151 TRP A HB2  1 
ATOM   2390 H HB3  . TRP A 1 187 ? 35.181  -2.862  2.633   1.00 21.68  ? 151 TRP A HB3  1 
ATOM   2391 H HD1  . TRP A 1 187 ? 35.288  0.219   0.736   1.00 24.67  ? 151 TRP A HD1  1 
ATOM   2392 H HE1  . TRP A 1 187 ? 34.844  -0.167  -1.600  1.00 26.29  ? 151 TRP A HE1  1 
ATOM   2393 H HE3  . TRP A 1 187 ? 34.126  -4.526  0.947   1.00 22.28  ? 151 TRP A HE3  1 
ATOM   2394 H HZ2  . TRP A 1 187 ? 34.121  -2.310  -3.171  1.00 19.95  ? 151 TRP A HZ2  1 
ATOM   2395 H HZ3  . TRP A 1 187 ? 33.626  -5.639  -1.011  1.00 20.15  ? 151 TRP A HZ3  1 
ATOM   2396 H HH2  . TRP A 1 187 ? 33.561  -4.543  -3.010  1.00 19.92  ? 151 TRP A HH2  1 
ATOM   2397 N N    . TRP A 1 188 ? 32.507  -3.649  2.921   1.00 16.79  ? 152 TRP A N    1 
ATOM   2398 C CA   . TRP A 1 188 ? 31.539  -4.546  2.314   1.00 13.56  ? 152 TRP A CA   1 
ATOM   2399 C C    . TRP A 1 188 ? 30.119  -4.182  2.724   1.00 14.20  ? 152 TRP A C    1 
ATOM   2400 O O    . TRP A 1 188 ? 29.219  -4.094  1.882   1.00 15.61  ? 152 TRP A O    1 
ATOM   2401 C CB   . TRP A 1 188 ? 31.894  -5.959  2.744   1.00 18.57  ? 152 TRP A CB   1 
ATOM   2402 C CG   . TRP A 1 188 ? 31.054  -7.031  2.142   1.00 14.19  ? 152 TRP A CG   1 
ATOM   2403 C CD1  . TRP A 1 188 ? 31.360  -7.814  1.071   1.00 16.34  ? 152 TRP A CD1  1 
ATOM   2404 C CD2  . TRP A 1 188 ? 29.759  -7.465  2.599   1.00 15.14  ? 152 TRP A CD2  1 
ATOM   2405 N NE1  . TRP A 1 188 ? 30.313  -8.701  0.816   1.00 15.32  ? 152 TRP A NE1  1 
ATOM   2406 C CE2  . TRP A 1 188 ? 29.347  -8.522  1.767   1.00 15.30  ? 152 TRP A CE2  1 
ATOM   2407 C CE3  . TRP A 1 188 ? 28.949  -7.090  3.652   1.00 14.49  ? 152 TRP A CE3  1 
ATOM   2408 C CZ2  . TRP A 1 188 ? 28.125  -9.166  1.939   1.00 16.48  ? 152 TRP A CZ2  1 
ATOM   2409 C CZ3  . TRP A 1 188 ? 27.725  -7.717  3.807   1.00 15.81  ? 152 TRP A CZ3  1 
ATOM   2410 C CH2  . TRP A 1 188 ? 27.338  -8.743  2.971   1.00 15.06  ? 152 TRP A CH2  1 
ATOM   2411 H H    . TRP A 1 188 ? 33.047  -4.033  3.468   1.00 20.14  ? 152 TRP A H    1 
ATOM   2412 H HA   . TRP A 1 188 ? 31.575  -4.485  1.347   1.00 16.27  ? 152 TRP A HA   1 
ATOM   2413 H HB2  . TRP A 1 188 ? 32.814  -6.135  2.492   1.00 22.28  ? 152 TRP A HB2  1 
ATOM   2414 H HB3  . TRP A 1 188 ? 31.796  -6.020  3.707   1.00 22.28  ? 152 TRP A HB3  1 
ATOM   2415 H HD1  . TRP A 1 188 ? 32.150  -7.766  0.582   1.00 19.59  ? 152 TRP A HD1  1 
ATOM   2416 H HE1  . TRP A 1 188 ? 30.280  -9.266  0.168   1.00 18.37  ? 152 TRP A HE1  1 
ATOM   2417 H HE3  . TRP A 1 188 ? 29.220  -6.428  4.246   1.00 17.38  ? 152 TRP A HE3  1 
ATOM   2418 H HZ2  . TRP A 1 188 ? 27.856  -9.856  1.376   1.00 19.76  ? 152 TRP A HZ2  1 
ATOM   2419 H HZ3  . TRP A 1 188 ? 27.154  -7.443  4.488   1.00 18.96  ? 152 TRP A HZ3  1 
ATOM   2420 H HH2  . TRP A 1 188 ? 26.517  -9.158  3.113   1.00 18.06  ? 152 TRP A HH2  1 
ATOM   2421 N N    . SER A 1 189 ? 29.914  -3.924  4.016   1.00 15.99  ? 153 SER A N    1 
ATOM   2422 C CA   . SER A 1 189 ? 28.581  -3.575  4.488   1.00 14.02  ? 153 SER A CA   1 
ATOM   2423 C C    . SER A 1 189 ? 28.128  -2.244  3.898   1.00 16.06  ? 153 SER A C    1 
ATOM   2424 O O    . SER A 1 189 ? 26.981  -2.105  3.475   1.00 15.66  ? 153 SER A O    1 
ATOM   2425 C CB   . SER A 1 189 ? 28.567  -3.574  6.024   1.00 15.93  ? 153 SER A CB   1 
ATOM   2426 O OG   . SER A 1 189 ? 29.501  -2.656  6.566   1.00 18.01  ? 153 SER A OG   1 
ATOM   2427 H H    . SER A 1 189 ? 30.519  -3.944  4.627   1.00 19.17  ? 153 SER A H    1 
ATOM   2428 H HA   . SER A 1 189 ? 27.937  -4.241  4.200   1.00 16.82  ? 153 SER A HA   1 
ATOM   2429 H HB2  . SER A 1 189 ? 27.678  -3.327  6.326   1.00 19.10  ? 153 SER A HB2  1 
ATOM   2430 H HB3  . SER A 1 189 ? 28.789  -4.464  6.337   1.00 19.10  ? 153 SER A HB3  1 
ATOM   2431 H HG   . SER A 1 189 ? 30.277  -2.849  6.308   1.00 21.60  ? 153 SER A HG   1 
ATOM   2432 N N    . THR A 1 190 ? 29.029  -1.272  3.779   1.00 13.83  ? 154 THR A N    1 
ATOM   2433 C CA   . THR A 1 190 ? 28.654  -0.041  3.104   1.00 15.67  ? 154 THR A CA   1 
ATOM   2434 C C    . THR A 1 190 ? 28.364  -0.285  1.628   1.00 15.89  ? 154 THR A C    1 
ATOM   2435 O O    . THR A 1 190 ? 27.436  0.282   1.073   1.00 15.60  ? 154 THR A O    1 
ATOM   2436 C CB   . THR A 1 190 ? 29.789  0.983   3.267   1.00 17.77  ? 154 THR A CB   1 
ATOM   2437 O OG1  . THR A 1 190 ? 29.892  1.339   4.642   1.00 18.34  ? 154 THR A OG1  1 
ATOM   2438 C CG2  . THR A 1 190 ? 29.567  2.153   2.430   1.00 20.78  ? 154 THR A CG2  1 
ATOM   2439 H H    . THR A 1 190 ? 29.838  -1.301  4.071   1.00 16.59  ? 154 THR A H    1 
ATOM   2440 H HA   . THR A 1 190 ? 27.848  0.316   3.507   1.00 18.79  ? 154 THR A HA   1 
ATOM   2441 H HB   . THR A 1 190 ? 30.633  0.601   2.978   1.00 21.31  ? 154 THR A HB   1 
ATOM   2442 H HG1  . THR A 1 190 ? 30.520  1.885   4.752   1.00 22.00  ? 154 THR A HG1  1 
ATOM   2443 H HG21 . THR A 1 190 ? 30.166  2.869   2.695   1.00 24.92  ? 154 THR A HG21 1 
ATOM   2444 H HG22 . THR A 1 190 ? 29.732  1.932   1.500   1.00 24.92  ? 154 THR A HG22 1 
ATOM   2445 H HG23 . THR A 1 190 ? 28.651  2.458   2.523   1.00 24.92  ? 154 THR A HG23 1 
ATOM   2446 N N    . THR A 1 191 ? 29.121  -1.155  0.994   1.00 13.77  ? 155 THR A N    1 
ATOM   2447 C CA   . THR A 1 191 ? 28.935  -1.405  -0.431  1.00 14.43  ? 155 THR A CA   1 
ATOM   2448 C C    . THR A 1 191 ? 27.581  -2.052  -0.685  1.00 11.90  ? 155 THR A C    1 
ATOM   2449 O O    . THR A 1 191 ? 26.877  -1.697  -1.627  1.00 16.02  ? 155 THR A O    1 
ATOM   2450 C CB   . THR A 1 191 ? 30.062  -2.304  -0.932  1.00 18.95  ? 155 THR A CB   1 
ATOM   2451 O OG1  . THR A 1 191 ? 31.265  -1.532  -0.990  1.00 18.05  ? 155 THR A OG1  1 
ATOM   2452 C CG2  . THR A 1 191 ? 29.762  -2.873  -2.315  1.00 18.84  ? 155 THR A CG2  1 
ATOM   2453 H H    . THR A 1 191 ? 29.750  -1.616  1.357   1.00 16.52  ? 155 THR A H    1 
ATOM   2454 H HA   . THR A 1 191 ? 28.967  -0.568  -0.919  1.00 17.30  ? 155 THR A HA   1 
ATOM   2455 H HB   . THR A 1 191 ? 30.166  -3.056  -0.329  1.00 22.73  ? 155 THR A HB   1 
ATOM   2456 H HG1  . THR A 1 191 ? 31.924  -2.036  -1.118  1.00 21.65  ? 155 THR A HG1  1 
ATOM   2457 H HG21 . THR A 1 191 ? 30.531  -3.364  -2.646  1.00 22.60  ? 155 THR A HG21 1 
ATOM   2458 H HG22 . THR A 1 191 ? 29.001  -3.473  -2.269  1.00 22.60  ? 155 THR A HG22 1 
ATOM   2459 H HG23 . THR A 1 191 ? 29.559  -2.153  -2.933  1.00 22.60  ? 155 THR A HG23 1 
ATOM   2460 N N    . VAL A 1 192 ? 27.241  -3.043  0.114   1.00 15.07  ? 156 VAL A N    1 
ATOM   2461 C CA   . VAL A 1 192 ? 25.950  -3.696  -0.068  1.00 14.45  ? 156 VAL A CA   1 
ATOM   2462 C C    . VAL A 1 192 ? 24.844  -2.691  0.158   1.00 13.98  ? 156 VAL A C    1 
ATOM   2463 O O    . VAL A 1 192 ? 23.876  -2.643  -0.599  1.00 17.11  ? 156 VAL A O    1 
ATOM   2464 C CB   . VAL A 1 192 ? 25.790  -4.900  0.863   1.00 17.36  ? 156 VAL A CB   1 
ATOM   2465 C CG1  . VAL A 1 192 ? 24.396  -5.525  0.665   1.00 16.49  ? 156 VAL A CG1  1 
ATOM   2466 C CG2  . VAL A 1 192 ? 26.878  -5.940  0.586   1.00 18.60  ? 156 VAL A CG2  1 
ATOM   2467 H H    . VAL A 1 192 ? 27.723  -3.354  0.755   1.00 18.08  ? 156 VAL A H    1 
ATOM   2468 H HA   . VAL A 1 192 ? 25.905  -4.027  -0.979  1.00 17.33  ? 156 VAL A HA   1 
ATOM   2469 H HB   . VAL A 1 192 ? 25.880  -4.607  1.783   1.00 20.82  ? 156 VAL A HB   1 
ATOM   2470 H HG11 . VAL A 1 192 ? 24.341  -6.343  1.183   1.00 19.78  ? 156 VAL A HG11 1 
ATOM   2471 H HG12 . VAL A 1 192 ? 23.722  -4.896  0.967   1.00 19.78  ? 156 VAL A HG12 1 
ATOM   2472 H HG13 . VAL A 1 192 ? 24.268  -5.720  -0.276  1.00 19.78  ? 156 VAL A HG13 1 
ATOM   2473 H HG21 . VAL A 1 192 ? 26.834  -6.630  1.266   1.00 22.31  ? 156 VAL A HG21 1 
ATOM   2474 H HG22 . VAL A 1 192 ? 26.728  -6.328  -0.290  1.00 22.31  ? 156 VAL A HG22 1 
ATOM   2475 H HG23 . VAL A 1 192 ? 27.744  -5.505  0.612   1.00 22.31  ? 156 VAL A HG23 1 
ATOM   2476 N N    . ALA A 1 193 ? 24.918  -1.934  1.255   1.00 14.04  ? 157 ALA A N    1 
ATOM   2477 C CA   . ALA A 1 193 ? 23.910  -0.889  1.464   1.00 14.96  ? 157 ALA A CA   1 
ATOM   2478 C C    . ALA A 1 193 ? 23.849  0.080   0.272   1.00 20.54  ? 157 ALA A C    1 
ATOM   2479 O O    . ALA A 1 193 ? 22.760  0.501   -0.151  1.00 17.62  ? 157 ALA A O    1 
ATOM   2480 C CB   . ALA A 1 193 ? 24.184  -0.167  2.778   1.00 16.16  ? 157 ALA A CB   1 
ATOM   2481 H H    . ALA A 1 193 ? 25.517  -2.000  1.869   1.00 16.83  ? 157 ALA A H    1 
ATOM   2482 H HA   . ALA A 1 193 ? 23.032  -1.296  1.536   1.00 17.95  ? 157 ALA A HA   1 
ATOM   2483 H HB1  . ALA A 1 193 ? 23.472  0.471   2.942   1.00 19.38  ? 157 ALA A HB1  1 
ATOM   2484 H HB2  . ALA A 1 193 ? 24.215  -0.819  3.496   1.00 19.38  ? 157 ALA A HB2  1 
ATOM   2485 H HB3  . ALA A 1 193 ? 25.034  0.295   2.713   1.00 19.38  ? 157 ALA A HB3  1 
ATOM   2486 N N    . LYS A 1 194 ? 25.001  0.456   -0.290  1.00 16.09  ? 158 LYS A N    1 
ATOM   2487 C CA   . LYS A 1 194 ? 24.998  1.278   -1.487  1.00 17.16  ? 158 LYS A CA   1 
ATOM   2488 C C    . LYS A 1 194 ? 24.319  0.570   -2.647  1.00 20.36  ? 158 LYS A C    1 
ATOM   2489 O O    . LYS A 1 194 ? 23.568  1.186   -3.406  1.00 20.82  ? 158 LYS A O    1 
ATOM   2490 C CB   . LYS A 1 194 ? 26.426  1.689   -1.870  1.00 16.33  ? 158 LYS A CB   1 
ATOM   2491 C CG   . LYS A 1 194 ? 26.466  2.504   -3.148  1.00 18.22  ? 158 LYS A CG   1 
ATOM   2492 C CD   . LYS A 1 194 ? 27.858  3.065   -3.417  1.00 22.94  ? 158 LYS A CD   1 
ATOM   2493 C CE   . LYS A 1 194 ? 27.867  3.993   -4.624  1.00 34.90  ? 158 LYS A CE   1 
ATOM   2494 N NZ   . LYS A 1 194 ? 29.240  4.444   -4.997  1.00 37.43  ? 158 LYS A NZ   1 
ATOM   2495 H H    . LYS A 1 194 ? 25.783  0.249   0.002   1.00 19.30  ? 158 LYS A H    1 
ATOM   2496 H HA   . LYS A 1 194 ? 24.500  2.088   -1.294  1.00 20.59  ? 158 LYS A HA   1 
ATOM   2497 H HB2  . LYS A 1 194 ? 26.804  2.227   -1.157  1.00 19.59  ? 158 LYS A HB2  1 
ATOM   2498 H HB3  . LYS A 1 194 ? 26.961  0.891   -2.004  1.00 19.59  ? 158 LYS A HB3  1 
ATOM   2499 H HG2  . LYS A 1 194 ? 26.216  1.939   -3.896  1.00 21.85  ? 158 LYS A HG2  1 
ATOM   2500 H HG3  . LYS A 1 194 ? 25.847  3.247   -3.073  1.00 21.85  ? 158 LYS A HG3  1 
ATOM   2501 H HD2  . LYS A 1 194 ? 28.156  3.570   -2.644  1.00 27.51  ? 158 LYS A HD2  1 
ATOM   2502 H HD3  . LYS A 1 194 ? 28.471  2.333   -3.591  1.00 27.51  ? 158 LYS A HD3  1 
ATOM   2503 H HE2  . LYS A 1 194 ? 27.489  3.525   -5.385  1.00 41.87  ? 158 LYS A HE2  1 
ATOM   2504 H HE3  . LYS A 1 194 ? 27.338  4.780   -4.422  1.00 41.87  ? 158 LYS A HE3  1 
ATOM   2505 H HZ1  . LYS A 1 194 ? 29.224  5.302   -5.236  1.00 44.90  ? 158 LYS A HZ1  1 
ATOM   2506 H HZ2  . LYS A 1 194 ? 29.791  4.347   -4.305  1.00 44.90  ? 158 LYS A HZ2  1 
ATOM   2507 H HZ3  . LYS A 1 194 ? 29.545  3.960   -5.679  1.00 44.90  ? 158 LYS A HZ3  1 
ATOM   2508 N N    . GLY A 1 195 ? 24.492  -0.742  -2.754  1.00 18.00  ? 159 GLY A N    1 
ATOM   2509 C CA   . GLY A 1 195 ? 23.845  -1.453  -3.845  1.00 16.98  ? 159 GLY A CA   1 
ATOM   2510 C C    . GLY A 1 195 ? 22.337  -1.523  -3.655  1.00 16.29  ? 159 GLY A C    1 
ATOM   2511 O O    . GLY A 1 195 ? 21.574  -1.456  -4.615  1.00 13.89  ? 159 GLY A O    1 
ATOM   2512 H H    . GLY A 1 195 ? 24.963  -1.229  -2.224  1.00 21.60  ? 159 GLY A H    1 
ATOM   2513 H HA2  . GLY A 1 195 ? 24.030  -0.998  -4.682  1.00 20.37  ? 159 GLY A HA2  1 
ATOM   2514 H HA3  . GLY A 1 195 ? 24.193  -2.357  -3.894  1.00 20.37  ? 159 GLY A HA3  1 
ATOM   2515 N N    . VAL A 1 196 ? 21.894  -1.681  -2.407  1.00 13.38  ? 160 VAL A N    1 
ATOM   2516 C CA   . VAL A 1 196 ? 20.456  -1.677  -2.143  1.00 14.74  ? 160 VAL A CA   1 
ATOM   2517 C C    . VAL A 1 196 ? 19.885  -0.303  -2.482  1.00 16.30  ? 160 VAL A C    1 
ATOM   2518 O O    . VAL A 1 196 ? 18.831  -0.193  -3.113  1.00 18.05  ? 160 VAL A O    1 
ATOM   2519 C CB   . VAL A 1 196 ? 20.189  -2.094  -0.679  1.00 12.97  ? 160 VAL A CB   1 
ATOM   2520 C CG1  . VAL A 1 196 ? 18.726  -1.793  -0.283  1.00 21.35  ? 160 VAL A CG1  1 
ATOM   2521 C CG2  . VAL A 1 196 ? 20.526  -3.574  -0.429  1.00 14.16  ? 160 VAL A CG2  1 
ATOM   2522 H H    . VAL A 1 196 ? 22.392  -1.790  -1.715  1.00 16.04  ? 160 VAL A H    1 
ATOM   2523 H HA   . VAL A 1 196 ? 20.013  -2.329  -2.709  1.00 17.68  ? 160 VAL A HA   1 
ATOM   2524 H HB   . VAL A 1 196 ? 20.776  -1.568  -0.114  1.00 15.56  ? 160 VAL A HB   1 
ATOM   2525 H HG11 . VAL A 1 196 ? 18.539  -2.209  0.574   1.00 25.61  ? 160 VAL A HG11 1 
ATOM   2526 H HG12 . VAL A 1 196 ? 18.607  -0.833  -0.217  1.00 25.61  ? 160 VAL A HG12 1 
ATOM   2527 H HG13 . VAL A 1 196 ? 18.134  -2.154  -0.962  1.00 25.61  ? 160 VAL A HG13 1 
ATOM   2528 H HG21 . VAL A 1 196 ? 20.509  -3.745  0.526   1.00 16.98  ? 160 VAL A HG21 1 
ATOM   2529 H HG22 . VAL A 1 196 ? 19.867  -4.128  -0.876  1.00 16.98  ? 160 VAL A HG22 1 
ATOM   2530 H HG23 . VAL A 1 196 ? 21.410  -3.761  -0.782  1.00 16.98  ? 160 VAL A HG23 1 
ATOM   2531 N N    . ALA A 1 197 ? 20.596  0.769   -2.104  1.00 19.03  ? 161 ALA A N    1 
ATOM   2532 C CA   . ALA A 1 197 ? 20.095  2.119   -2.368  1.00 19.26  ? 161 ALA A CA   1 
ATOM   2533 C C    . ALA A 1 197 ? 20.086  2.429   -3.855  1.00 23.09  ? 161 ALA A C    1 
ATOM   2534 O O    . ALA A 1 197 ? 19.104  2.969   -4.381  1.00 27.79  ? 161 ALA A O    1 
ATOM   2535 C CB   . ALA A 1 197 ? 20.957  3.148   -1.630  1.00 22.74  ? 161 ALA A CB   1 
ATOM   2536 H H    . ALA A 1 197 ? 21.356  0.740   -1.702  1.00 22.82  ? 161 ALA A H    1 
ATOM   2537 H HA   . ALA A 1 197 ? 19.185  2.178   -2.037  1.00 23.10  ? 161 ALA A HA   1 
ATOM   2538 H HB1  . ALA A 1 197 ? 20.608  4.036   -1.805  1.00 27.27  ? 161 ALA A HB1  1 
ATOM   2539 H HB2  . ALA A 1 197 ? 20.925  2.962   -0.678  1.00 27.27  ? 161 ALA A HB2  1 
ATOM   2540 H HB3  . ALA A 1 197 ? 21.870  3.082   -1.949  1.00 27.27  ? 161 ALA A HB3  1 
ATOM   2541 N N    . GLU A 1 198 ? 21.157  2.081   -4.557  1.00 20.94  ? 162 GLU A N    1 
ATOM   2542 C CA   . GLU A 1 198 ? 21.255  2.433   -5.970  1.00 25.60  ? 162 GLU A CA   1 
ATOM   2543 C C    . GLU A 1 198 ? 20.283  1.630   -6.813  1.00 25.46  ? 162 GLU A C    1 
ATOM   2544 O O    . GLU A 1 198 ? 19.816  2.113   -7.847  1.00 23.84  ? 162 GLU A O    1 
ATOM   2545 C CB   . GLU A 1 198 ? 22.688  2.220   -6.474  1.00 23.36  ? 162 GLU A CB   1 
ATOM   2546 C CG   . GLU A 1 198 ? 23.631  3.309   -6.057  1.00 19.13  ? 162 GLU A CG   1 
ATOM   2547 C CD   . GLU A 1 198 ? 24.900  3.316   -6.842  1.00 28.27  ? 162 GLU A CD   1 
ATOM   2548 O OE1  . GLU A 1 198 ? 25.398  2.228   -7.153  1.00 22.68  ? 162 GLU A OE1  1 
ATOM   2549 O OE2  . GLU A 1 198 ? 25.395  4.423   -7.153  1.00 35.99  ? 162 GLU A OE2  1 
ATOM   2550 H H    . GLU A 1 198 ? 21.832  1.648   -4.246  1.00 25.12  ? 162 GLU A H    1 
ATOM   2551 H HA   . GLU A 1 198 ? 21.040  3.374   -6.069  1.00 30.71  ? 162 GLU A HA   1 
ATOM   2552 H HB2  . GLU A 1 198 ? 23.024  1.382   -6.119  1.00 28.02  ? 162 GLU A HB2  1 
ATOM   2553 H HB3  . GLU A 1 198 ? 22.678  2.189   -7.444  1.00 28.02  ? 162 GLU A HB3  1 
ATOM   2554 H HG2  . GLU A 1 198 ? 23.197  4.167   -6.184  1.00 22.95  ? 162 GLU A HG2  1 
ATOM   2555 H HG3  . GLU A 1 198 ? 23.859  3.188   -5.122  1.00 22.95  ? 162 GLU A HG3  1 
ATOM   2556 N N    . SER A 1 199 ? 19.975  0.406   -6.401  1.00 18.79  ? 163 SER A N    1 
ATOM   2557 C CA   . SER A 1 199 ? 19.118  -0.450  -7.187  1.00 17.01  ? 163 SER A CA   1 
ATOM   2558 C C    . SER A 1 199 ? 17.648  -0.224  -6.885  1.00 20.65  ? 163 SER A C    1 
ATOM   2559 O O    . SER A 1 199 ? 16.804  -0.709  -7.636  1.00 24.68  ? 163 SER A O    1 
ATOM   2560 C CB   . SER A 1 199 ? 19.456  -1.917  -6.942  1.00 18.09  ? 163 SER A CB   1 
ATOM   2561 O OG   . SER A 1 199 ? 19.305  -2.224  -5.571  1.00 18.96  ? 163 SER A OG   1 
ATOM   2562 H H    . SER A 1 199 ? 20.254  0.054   -5.667  1.00 22.54  ? 163 SER A H    1 
ATOM   2563 H HA   . SER A 1 199 ? 19.273  -0.269  -8.127  1.00 20.40  ? 163 SER A HA   1 
ATOM   2564 H HB2  . SER A 1 199 ? 18.855  -2.474  -7.461  1.00 21.70  ? 163 SER A HB2  1 
ATOM   2565 H HB3  . SER A 1 199 ? 20.374  -2.082  -7.207  1.00 21.70  ? 163 SER A HB3  1 
ATOM   2566 H HG   . SER A 1 199 ? 19.787  -1.715  -5.108  1.00 22.74  ? 163 SER A HG   1 
ATOM   2567 N N    . GLY A 1 200 ? 17.322  0.483   -5.810  1.00 18.41  ? 164 GLY A N    1 
ATOM   2568 C CA   . GLY A 1 200 ? 15.937  0.585   -5.382  1.00 19.71  ? 164 GLY A CA   1 
ATOM   2569 C C    . GLY A 1 200 ? 15.351  -0.700  -4.869  1.00 21.25  ? 164 GLY A C    1 
ATOM   2570 O O    . GLY A 1 200 ? 14.127  -0.836  -4.816  1.00 19.92  ? 164 GLY A O    1 
ATOM   2571 H H    . GLY A 1 200 ? 17.881  0.911   -5.316  1.00 22.08  ? 164 GLY A H    1 
ATOM   2572 H HA2  . GLY A 1 200 ? 15.877  1.244   -4.672  1.00 23.64  ? 164 GLY A HA2  1 
ATOM   2573 H HA3  . GLY A 1 200 ? 15.399  0.879   -6.133  1.00 23.64  ? 164 GLY A HA3  1 
ATOM   2574 N N    . CYS A 1 201 ? 16.186  -1.626  -4.432  1.00 17.81  ? 165 CYS A N    1 
ATOM   2575 C CA   . CYS A 1 201 ? 15.711  -2.877  -3.867  1.00 15.01  ? 165 CYS A CA   1 
ATOM   2576 C C    . CYS A 1 201 ? 15.308  -2.679  -2.403  1.00 17.68  ? 165 CYS A C    1 
ATOM   2577 O O    . CYS A 1 201 ? 15.621  -1.667  -1.768  1.00 19.12  ? 165 CYS A O    1 
ATOM   2578 C CB   . CYS A 1 201 ? 16.780  -3.978  -3.988  1.00 11.96  ? 165 CYS A CB   1 
ATOM   2579 S SG   . CYS A 1 201 ? 16.957  -4.549  -5.644  1.00 16.15  ? 165 CYS A SG   1 
ATOM   2580 H H    . CYS A 1 201 ? 17.042  -1.554  -4.450  1.00 21.37  ? 165 CYS A H    1 
ATOM   2581 H HA   . CYS A 1 201 ? 14.931  -3.177  -4.359  1.00 18.00  ? 165 CYS A HA   1 
ATOM   2582 H HB2  . CYS A 1 201 ? 17.635  -3.626  -3.696  1.00 14.34  ? 165 CYS A HB2  1 
ATOM   2583 H HB3  . CYS A 1 201 ? 16.524  -4.732  -3.433  1.00 14.34  ? 165 CYS A HB3  1 
ATOM   2584 H HG   . CYS A 1 201 ? 17.758  -5.443  -5.666  1.00 19.37  ? 165 CYS A HG   1 
ATOM   2585 N N    . ASP A 1 202 ? 14.518  -3.644  -1.905  1.00 16.66  ? 166 ASP A N    1 
ATOM   2586 C CA   . ASP A 1 202 ? 13.923  -3.620  -0.582  1.00 15.15  ? 166 ASP A CA   1 
ATOM   2587 C C    . ASP A 1 202 ? 14.774  -4.309  0.453   1.00 16.45  ? 166 ASP A C    1 
ATOM   2588 O O    . ASP A 1 202 ? 14.322  -4.520  1.587   1.00 14.86  ? 166 ASP A O    1 
ATOM   2589 C CB   . ASP A 1 202 ? 12.525  -4.253  -0.665  1.00 14.80  ? 166 ASP A CB   1 
ATOM   2590 C CG   . ASP A 1 202 ? 11.681  -3.555  -1.685  1.00 21.20  ? 166 ASP A CG   1 
ATOM   2591 O OD1  . ASP A 1 202 ? 11.323  -2.397  -1.381  1.00 20.64  ? 166 ASP A OD1  1 
ATOM   2592 O OD2  . ASP A 1 202 ? 11.458  -4.093  -2.792  1.00 19.29  ? 166 ASP A OD2  1 
ATOM   2593 H H    . ASP A 1 202 ? 14.308  -4.352  -2.345  1.00 19.98  ? 166 ASP A H    1 
ATOM   2594 H HA   . ASP A 1 202 ? 13.822  -2.704  -0.280  1.00 18.17  ? 166 ASP A HA   1 
ATOM   2595 H HB2  . ASP A 1 202 ? 12.607  -5.185  -0.920  1.00 17.75  ? 166 ASP A HB2  1 
ATOM   2596 H HB3  . ASP A 1 202 ? 12.087  -4.181  0.197   1.00 17.75  ? 166 ASP A HB3  1 
ATOM   2597 N N    . GLY A 1 203 ? 16.022  -4.576  0.126   1.00 16.63  ? 167 GLY A N    1 
ATOM   2598 C CA   . GLY A 1 203 ? 16.922  -5.228  1.024   1.00 15.70  ? 167 GLY A CA   1 
ATOM   2599 C C    . GLY A 1 203 ? 17.895  -6.067  0.232   1.00 14.63  ? 167 GLY A C    1 
ATOM   2600 O O    . GLY A 1 203 ? 18.034  -5.915  -0.984  1.00 14.51  ? 167 GLY A O    1 
ATOM   2601 H H    . GLY A 1 203 ? 16.373  -4.380  -0.634  1.00 19.94  ? 167 GLY A H    1 
ATOM   2602 H HA2  . GLY A 1 203 ? 17.415  -4.569  1.539   1.00 18.82  ? 167 GLY A HA2  1 
ATOM   2603 H HA3  . GLY A 1 203 ? 16.430  -5.800  1.633   1.00 18.82  ? 167 GLY A HA3  1 
ATOM   2604 N N    . ALA A 1 204 ? 18.535  -6.976  0.945   1.00 14.58  ? 168 ALA A N    1 
ATOM   2605 C CA   . ALA A 1 204 ? 19.644  -7.720  0.397   1.00 14.85  ? 168 ALA A CA   1 
ATOM   2606 C C    . ALA A 1 204 ? 19.537  -9.195  0.712   1.00 14.57  ? 168 ALA A C    1 
ATOM   2607 O O    . ALA A 1 204 ? 19.177  -9.569  1.827   1.00 13.31  ? 168 ALA A O    1 
ATOM   2608 C CB   . ALA A 1 204 ? 20.972  -7.207  0.972   1.00 16.21  ? 168 ALA A CB   1 
ATOM   2609 H H    . ALA A 1 204 ? 18.340  -7.179  1.757   1.00 17.49  ? 168 ALA A H    1 
ATOM   2610 H HA   . ALA A 1 204 ? 19.624  -7.619  -0.568  1.00 17.80  ? 168 ALA A HA   1 
ATOM   2611 H HB1  . ALA A 1 204 ? 21.705  -7.634  0.502   1.00 19.44  ? 168 ALA A HB1  1 
ATOM   2612 H HB2  . ALA A 1 204 ? 21.018  -6.246  0.853   1.00 19.44  ? 168 ALA A HB2  1 
ATOM   2613 H HB3  . ALA A 1 204 ? 21.012  -7.425  1.916   1.00 19.44  ? 168 ALA A HB3  1 
ATOM   2614 N N    . PHE A 1 205 ? 19.930  -9.996  -0.265  1.00 11.76  ? 169 PHE A N    1 
ATOM   2615 C CA   . PHE A 1 205 ? 20.200  -11.423 -0.095  1.00 13.98  ? 169 PHE A CA   1 
ATOM   2616 C C    . PHE A 1 205 ? 21.712  -11.561 0.030   1.00 14.82  ? 169 PHE A C    1 
ATOM   2617 O O    . PHE A 1 205 ? 22.426  -11.302 -0.939  1.00 14.18  ? 169 PHE A O    1 
ATOM   2618 C CB   . PHE A 1 205 ? 19.679  -12.196 -1.298  1.00 13.26  ? 169 PHE A CB   1 
ATOM   2619 C CG   . PHE A 1 205 ? 19.934  -13.677 -1.252  1.00 10.95  ? 169 PHE A CG   1 
ATOM   2620 C CD1  . PHE A 1 205 ? 21.212  -14.198 -1.481  1.00 15.62  ? 169 PHE A CD1  1 
ATOM   2621 C CD2  . PHE A 1 205 ? 18.880  -14.563 -1.045  1.00 17.30  ? 169 PHE A CD2  1 
ATOM   2622 C CE1  . PHE A 1 205 ? 21.424  -15.536 -1.471  1.00 17.42  ? 169 PHE A CE1  1 
ATOM   2623 C CE2  . PHE A 1 205 ? 19.116  -15.914 -1.039  1.00 15.70  ? 169 PHE A CE2  1 
ATOM   2624 C CZ   . PHE A 1 205 ? 20.390  -16.388 -1.233  1.00 14.48  ? 169 PHE A CZ   1 
ATOM   2625 H H    . PHE A 1 205 ? 20.055  -9.729  -1.073  1.00 14.11  ? 169 PHE A H    1 
ATOM   2626 H HA   . PHE A 1 205 ? 19.770  -11.772 0.702   1.00 16.76  ? 169 PHE A HA   1 
ATOM   2627 H HB2  . PHE A 1 205 ? 18.720  -12.066 -1.356  1.00 15.90  ? 169 PHE A HB2  1 
ATOM   2628 H HB3  . PHE A 1 205 ? 20.110  -11.851 -2.096  1.00 15.90  ? 169 PHE A HB3  1 
ATOM   2629 H HD1  . PHE A 1 205 ? 21.923  -13.620 -1.641  1.00 18.73  ? 169 PHE A HD1  1 
ATOM   2630 H HD2  . PHE A 1 205 ? 18.018  -14.239 -0.912  1.00 20.75  ? 169 PHE A HD2  1 
ATOM   2631 H HE1  . PHE A 1 205 ? 22.276  -15.873 -1.628  1.00 20.89  ? 169 PHE A HE1  1 
ATOM   2632 H HE2  . PHE A 1 205 ? 18.414  -16.509 -0.904  1.00 18.82  ? 169 PHE A HE2  1 
ATOM   2633 H HZ   . PHE A 1 205 ? 20.549  -17.304 -1.201  1.00 17.37  ? 169 PHE A HZ   1 
ATOM   2634 N N    . ILE A 1 206 ? 22.157  -11.981 1.211   1.00 12.42  ? 170 ILE A N    1 
ATOM   2635 C CA   . ILE A 1 206 ? 23.576  -12.203 1.446   1.00 14.70  ? 170 ILE A CA   1 
ATOM   2636 C C    . ILE A 1 206 ? 23.898  -13.670 1.332   1.00 16.78  ? 170 ILE A C    1 
ATOM   2637 O O    . ILE A 1 206 ? 23.404  -14.469 2.093   1.00 16.05  ? 170 ILE A O    1 
ATOM   2638 C CB   . ILE A 1 206 ? 24.043  -11.709 2.800   1.00 15.86  ? 170 ILE A CB   1 
ATOM   2639 C CG1  . ILE A 1 206 ? 23.682  -10.229 2.960   1.00 15.78  ? 170 ILE A CG1  1 
ATOM   2640 C CG2  . ILE A 1 206 ? 25.538  -11.914 2.954   1.00 16.13  ? 170 ILE A CG2  1 
ATOM   2641 C CD1  . ILE A 1 206 ? 24.069  -9.369  1.782   1.00 19.22  ? 170 ILE A CD1  1 
ATOM   2642 H H    . ILE A 1 206 ? 21.669  -12.144 1.903   1.00 14.89  ? 170 ILE A H    1 
ATOM   2643 H HA   . ILE A 1 206 ? 24.093  -11.735 0.768   1.00 17.63  ? 170 ILE A HA   1 
ATOM   2644 H HB   . ILE A 1 206 ? 23.586  -12.216 3.488   1.00 19.02  ? 170 ILE A HB   1 
ATOM   2645 H HG12 . ILE A 1 206 ? 22.723  -10.153 3.079   1.00 18.93  ? 170 ILE A HG12 1 
ATOM   2646 H HG13 . ILE A 1 206 ? 24.139  -9.880  3.740   1.00 18.93  ? 170 ILE A HG13 1 
ATOM   2647 H HG21 . ILE A 1 206 ? 25.874  -11.288 3.600   1.00 19.34  ? 170 ILE A HG21 1 
ATOM   2648 H HG22 . ILE A 1 206 ? 25.707  -12.814 3.249   1.00 19.34  ? 170 ILE A HG22 1 
ATOM   2649 H HG23 . ILE A 1 206 ? 25.958  -11.763 2.103   1.00 19.34  ? 170 ILE A HG23 1 
ATOM   2650 H HD11 . ILE A 1 206 ? 24.165  -8.460  2.079   1.00 23.05  ? 170 ILE A HD11 1 
ATOM   2651 H HD12 . ILE A 1 206 ? 24.903  -9.687  1.427   1.00 23.05  ? 170 ILE A HD12 1 
ATOM   2652 H HD13 . ILE A 1 206 ? 23.383  -9.426  1.113   1.00 23.05  ? 170 ILE A HD13 1 
ATOM   2653 N N    . ASP A 1 207 ? 24.745  -13.983 0.366   1.00 17.27  ? 171 ASP A N    1 
ATOM   2654 C CA   . ASP A 1 207 ? 25.106  -15.345 0.114   1.00 15.94  ? 171 ASP A CA   1 
ATOM   2655 C C    . ASP A 1 207 ? 26.388  -15.727 0.834   1.00 17.65  ? 171 ASP A C    1 
ATOM   2656 O O    . ASP A 1 207 ? 27.301  -14.941 0.912   1.00 18.12  ? 171 ASP A O    1 
ATOM   2657 C CB   . ASP A 1 207 ? 25.288  -15.536 -1.380  1.00 18.93  ? 171 ASP A CB   1 
ATOM   2658 C CG   . ASP A 1 207 ? 25.188  -16.986 -1.805  1.00 22.30  ? 171 ASP A CG   1 
ATOM   2659 O OD1  . ASP A 1 207 ? 25.111  -17.867 -0.945  1.00 19.43  ? 171 ASP A OD1  1 
ATOM   2660 O OD2  . ASP A 1 207 ? 25.198  -17.243 -3.013  1.00 20.61  ? 171 ASP A OD2  1 
ATOM   2661 H H    . ASP A 1 207 ? 25.137  -13.427 -0.165  1.00 20.71  ? 171 ASP A H    1 
ATOM   2662 H HA   . ASP A 1 207 ? 24.386  -15.939 0.414   1.00 19.12  ? 171 ASP A HA   1 
ATOM   2663 H HB2  . ASP A 1 207 ? 24.600  -15.036 -1.848  1.00 22.70  ? 171 ASP A HB2  1 
ATOM   2664 H HB3  . ASP A 1 207 ? 26.166  -15.206 -1.629  1.00 22.70  ? 171 ASP A HB3  1 
ATOM   2665 N N    . GLN A 1 208 ? 26.402  -16.937 1.372   1.00 30.00  ? 172 GLN A N    1 
ATOM   2666 C CA   . GLN A 1 208 ? 27.574  -17.417 2.080   1.00 30.00  ? 172 GLN A CA   1 
ATOM   2667 C C    . GLN A 1 208 ? 27.633  -16.890 3.491   1.00 30.00  ? 172 GLN A C    1 
ATOM   2668 O O    . GLN A 1 208 ? 27.420  -15.707 3.723   1.00 30.00  ? 172 GLN A O    1 
ATOM   2669 C CB   . GLN A 1 208 ? 28.858  -17.039 1.341   1.00 30.00  ? 172 GLN A CB   1 
ATOM   2670 C CG   . GLN A 1 208 ? 28.819  -17.379 -0.131  1.00 30.00  ? 172 GLN A CG   1 
ATOM   2671 C CD   . GLN A 1 208 ? 29.797  -18.472 -0.452  1.00 30.00  ? 172 GLN A CD   1 
ATOM   2672 O OE1  . GLN A 1 208 ? 29.419  -19.605 -0.745  1.00 30.00  ? 172 GLN A OE1  1 
ATOM   2673 N NE2  . GLN A 1 208 ? 31.067  -18.150 -0.356  1.00 30.00  ? 172 GLN A NE2  1 
ATOM   2674 N N    . MET A 1 209 ? 27.870  -17.775 4.430   1.00 25.05  ? 173 MET A N    1 
ATOM   2675 C CA   . MET A 1 209 ? 28.016  -17.387 5.823   1.00 23.93  ? 173 MET A CA   1 
ATOM   2676 C C    . MET A 1 209 ? 29.294  -17.906 6.422   1.00 25.03  ? 173 MET A C    1 
ATOM   2677 O O    . MET A 1 209 ? 29.568  -17.635 7.559   1.00 26.85  ? 173 MET A O    1 
ATOM   2678 C CB   . MET A 1 209 ? 26.858  -18.011 6.600   1.00 26.17  ? 173 MET A CB   1 
ATOM   2679 C CG   . MET A 1 209 ? 25.490  -17.528 6.171   1.00 27.56  ? 173 MET A CG   1 
ATOM   2680 S SD   . MET A 1 209 ? 25.183  -15.900 6.859   1.00 28.00  ? 173 MET A SD   1 
ATOM   2681 C CE   . MET A 1 209 ? 24.612  -14.955 5.448   1.00 21.87  ? 173 MET A CE   1 
ATOM   2682 H H    . MET A 1 209 ? 27.916  -18.626 4.308   1.00 30.05  ? 173 MET A H    1 
ATOM   2683 H HA   . MET A 1 209 ? 27.976  -16.416 5.929   1.00 28.70  ? 173 MET A HA   1 
ATOM   2684 H HB2  . MET A 1 209 ? 26.884  -18.970 6.463   1.00 31.39  ? 173 MET A HB2  1 
ATOM   2685 H HB3  . MET A 1 209 ? 26.959  -17.807 7.542   1.00 31.39  ? 173 MET A HB3  1 
ATOM   2686 H HG2  . MET A 1 209 ? 25.451  -17.464 5.205   1.00 33.06  ? 173 MET A HG2  1 
ATOM   2687 H HG3  . MET A 1 209 ? 24.810  -18.137 6.502   1.00 33.06  ? 173 MET A HG3  1 
ATOM   2688 H HE1  . MET A 1 209 ? 24.482  -14.041 5.709   1.00 26.23  ? 173 MET A HE1  1 
ATOM   2689 H HE2  . MET A 1 209 ? 25.270  -15.003 4.752   1.00 26.23  ? 173 MET A HE2  1 
ATOM   2690 H HE3  . MET A 1 209 ? 23.783  -15.329 5.134   1.00 26.23  ? 173 MET A HE3  1 
ATOM   2691 N N    . HIS A 1 210 ? 30.065  -18.662 5.662   1.00 23.56  ? 174 HIS A N    1 
ATOM   2692 C CA   . HIS A 1 210 ? 31.216  -19.354 6.212   1.00 22.52  ? 174 HIS A CA   1 
ATOM   2693 C C    . HIS A 1 210 ? 32.495  -18.587 6.443   1.00 26.88  ? 174 HIS A C    1 
ATOM   2694 O O    . HIS A 1 210 ? 33.361  -19.036 7.158   1.00 23.12  ? 174 HIS A O    1 
ATOM   2695 C CB   . HIS A 1 210 ? 31.540  -20.544 5.309   1.00 25.92  ? 174 HIS A CB   1 
ATOM   2696 C CG   . HIS A 1 210 ? 31.629  -20.226 3.855   1.00 19.74  ? 174 HIS A CG   1 
ATOM   2697 N ND1  . HIS A 1 210 ? 32.637  -19.467 3.314   1.00 19.78  ? 174 HIS A ND1  1 
ATOM   2698 C CD2  . HIS A 1 210 ? 30.855  -20.612 2.821   1.00 18.51  ? 174 HIS A CD2  1 
ATOM   2699 C CE1  . HIS A 1 210 ? 32.473  -19.382 2.010   1.00 22.74  ? 174 HIS A CE1  1 
ATOM   2700 N NE2  . HIS A 1 210 ? 31.397  -20.070 1.687   1.00 18.68  ? 174 HIS A NE2  1 
ATOM   2701 H H    . HIS A 1 210 ? 29.929  -18.773 4.825   1.00 28.26  ? 174 HIS A H    1 
ATOM   2702 H HA   . HIS A 1 210 ? 30.954  -19.727 7.078   1.00 27.02  ? 174 HIS A HA   1 
ATOM   2703 H HB2  . HIS A 1 210 ? 32.404  -20.894 5.576   1.00 31.10  ? 174 HIS A HB2  1 
ATOM   2704 H HB3  . HIS A 1 210 ? 30.858  -21.223 5.419   1.00 31.10  ? 174 HIS A HB3  1 
ATOM   2705 H HD2  . HIS A 1 210 ? 30.099  -21.149 2.869   1.00 22.20  ? 174 HIS A HD2  1 
ATOM   2706 H HE1  . HIS A 1 210 ? 33.018  -18.913 1.419   1.00 27.28  ? 174 HIS A HE1  1 
ATOM   2707 H HE2  . HIS A 1 210 ? 31.090  -20.180 0.907   1.00 22.40  ? 174 HIS A HE2  1 
ATOM   2708 N N    . GLY A 1 211 ? 32.602  -17.432 5.845   1.00 22.98  ? 175 GLY A N    1 
ATOM   2709 C CA   . GLY A 1 211 ? 33.852  -16.694 5.934   1.00 21.28  ? 175 GLY A CA   1 
ATOM   2710 C C    . GLY A 1 211 ? 35.101  -17.535 5.731   1.00 22.16  ? 175 GLY A C    1 
ATOM   2711 O O    . GLY A 1 211 ? 36.156  -17.269 6.320   1.00 23.27  ? 175 GLY A O    1 
ATOM   2712 H H    . GLY A 1 211 ? 31.984  -17.043 5.391   1.00 27.56  ? 175 GLY A H    1 
ATOM   2713 H HA2  . GLY A 1 211 ? 33.851  -15.997 5.258   1.00 25.53  ? 175 GLY A HA2  1 
ATOM   2714 H HA3  . GLY A 1 211 ? 33.910  -16.283 6.810   1.00 25.53  ? 175 GLY A HA3  1 
ATOM   2715 N N    . PHE A 1 212 ? 35.023  -18.514 4.857   1.00 24.57  ? 176 PHE A N    1 
ATOM   2716 C CA   . PHE A 1 212 ? 36.136  -19.408 4.613   1.00 23.28  ? 176 PHE A CA   1 
ATOM   2717 C C    . PHE A 1 212 ? 36.755  -19.910 5.906   1.00 26.12  ? 176 PHE A C    1 
ATOM   2718 O O    . PHE A 1 212 ? 37.957  -19.948 6.024   1.00 29.18  ? 176 PHE A O    1 
ATOM   2719 C CB   . PHE A 1 212 ? 37.170  -18.720 3.736   1.00 20.98  ? 176 PHE A CB   1 
ATOM   2720 C CG   . PHE A 1 212 ? 36.621  -18.194 2.449   1.00 18.54  ? 176 PHE A CG   1 
ATOM   2721 C CD1  . PHE A 1 212 ? 36.572  -18.987 1.328   1.00 25.13  ? 176 PHE A CD1  1 
ATOM   2722 C CD2  . PHE A 1 212 ? 36.163  -16.898 2.363   1.00 20.13  ? 176 PHE A CD2  1 
ATOM   2723 C CE1  . PHE A 1 212 ? 36.065  -18.503 0.140   1.00 23.48  ? 176 PHE A CE1  1 
ATOM   2724 C CE2  . PHE A 1 212 ? 35.655  -16.408 1.182   1.00 19.67  ? 176 PHE A CE2  1 
ATOM   2725 C CZ   . PHE A 1 212 ? 35.606  -17.209 0.068   1.00 25.39  ? 176 PHE A CZ   1 
ATOM   2726 H H    . PHE A 1 212 ? 34.361  -18.666 4.371   1.00 29.48  ? 176 PHE A H    1 
ATOM   2727 H HA   . PHE A 1 212 ? 35.809  -20.192 4.122   1.00 27.92  ? 176 PHE A HA   1 
ATOM   2728 H HB2  . PHE A 1 212 ? 37.552  -17.974 4.224   1.00 25.17  ? 176 PHE A HB2  1 
ATOM   2729 H HB3  . PHE A 1 212 ? 37.864  -19.361 3.516   1.00 25.17  ? 176 PHE A HB3  1 
ATOM   2730 H HD1  . PHE A 1 212 ? 36.880  -19.863 1.377   1.00 30.14  ? 176 PHE A HD1  1 
ATOM   2731 H HD2  . PHE A 1 212 ? 36.193  -16.353 3.117   1.00 24.15  ? 176 PHE A HD2  1 
ATOM   2732 H HE1  . PHE A 1 212 ? 36.036  -19.048 -0.613  1.00 28.16  ? 176 PHE A HE1  1 
ATOM   2733 H HE2  . PHE A 1 212 ? 35.348  -15.531 1.136   1.00 23.60  ? 176 PHE A HE2  1 
ATOM   2734 H HZ   . PHE A 1 212 ? 35.267  -16.875 -0.732  1.00 30.46  ? 176 PHE A HZ   1 
ATOM   2735 N N    . ALA A 1 213 ? 35.941  -20.323 6.863   1.00 23.58  ? 177 ALA A N    1 
ATOM   2736 C CA   . ALA A 1 213 ? 36.499  -20.730 8.160   1.00 29.88  ? 177 ALA A CA   1 
ATOM   2737 C C    . ALA A 1 213 ? 37.497  -21.889 8.022   1.00 37.28  ? 177 ALA A C    1 
ATOM   2738 O O    . ALA A 1 213 ? 38.483  -21.947 8.773   1.00 35.14  ? 177 ALA A O    1 
ATOM   2739 C CB   . ALA A 1 213 ? 35.381  -21.096 9.132   1.00 25.73  ? 177 ALA A CB   1 
ATOM   2740 H H    . ALA A 1 213 ? 35.083  -20.358 6.804   1.00 28.28  ? 177 ALA A H    1 
ATOM   2741 H HA   . ALA A 1 213 ? 36.979  -19.974 8.534   1.00 35.84  ? 177 ALA A HA   1 
ATOM   2742 H HB1  . ALA A 1 213 ? 35.774  -21.381 9.972   1.00 30.86  ? 177 ALA A HB1  1 
ATOM   2743 H HB2  . ALA A 1 213 ? 34.821  -20.317 9.277   1.00 30.86  ? 177 ALA A HB2  1 
ATOM   2744 H HB3  . ALA A 1 213 ? 34.855  -21.816 8.751   1.00 30.86  ? 177 ALA A HB3  1 
ATOM   2745 N N    . TRP A 1 214 ? 37.288  -22.792 7.048   1.00 34.78  ? 178 TRP A N    1 
ATOM   2746 C CA   . TRP A 1 214 ? 38.190  -23.936 6.871   1.00 35.49  ? 178 TRP A CA   1 
ATOM   2747 C C    . TRP A 1 214 ? 39.591  -23.508 6.440   1.00 35.84  ? 178 TRP A C    1 
ATOM   2748 O O    . TRP A 1 214 ? 40.539  -24.301 6.545   1.00 35.57  ? 178 TRP A O    1 
ATOM   2749 C CB   . TRP A 1 214 ? 37.600  -24.933 5.855   1.00 36.49  ? 178 TRP A CB   1 
ATOM   2750 C CG   . TRP A 1 214 ? 37.225  -24.327 4.551   1.00 32.65  ? 178 TRP A CG   1 
ATOM   2751 C CD1  . TRP A 1 214 ? 38.004  -24.207 3.445   1.00 40.49  ? 178 TRP A CD1  1 
ATOM   2752 C CD2  . TRP A 1 214 ? 35.957  -23.748 4.215   1.00 37.72  ? 178 TRP A CD2  1 
ATOM   2753 N NE1  . TRP A 1 214 ? 37.306  -23.582 2.438   1.00 36.43  ? 178 TRP A NE1  1 
ATOM   2754 C CE2  . TRP A 1 214 ? 36.050  -23.282 2.891   1.00 35.26  ? 178 TRP A CE2  1 
ATOM   2755 C CE3  . TRP A 1 214 ? 34.753  -23.582 4.907   1.00 41.50  ? 178 TRP A CE3  1 
ATOM   2756 C CZ2  . TRP A 1 214 ? 34.997  -22.651 2.249   1.00 26.43  ? 178 TRP A CZ2  1 
ATOM   2757 C CZ3  . TRP A 1 214 ? 33.697  -22.967 4.261   1.00 38.82  ? 178 TRP A CZ3  1 
ATOM   2758 C CH2  . TRP A 1 214 ? 33.822  -22.526 2.937   1.00 32.47  ? 178 TRP A CH2  1 
ATOM   2759 H H    . TRP A 1 214 ? 36.638  -22.763 6.485   1.00 41.72  ? 178 TRP A H    1 
ATOM   2760 H HA   . TRP A 1 214 ? 38.272  -24.399 7.719   1.00 42.58  ? 178 TRP A HA   1 
ATOM   2761 H HB2  . TRP A 1 214 ? 38.258  -25.623 5.679   1.00 43.78  ? 178 TRP A HB2  1 
ATOM   2762 H HB3  . TRP A 1 214 ? 36.800  -25.327 6.237   1.00 43.78  ? 178 TRP A HB3  1 
ATOM   2763 H HD1  . TRP A 1 214 ? 38.883  -24.505 3.379   1.00 48.58  ? 178 TRP A HD1  1 
ATOM   2764 H HE1  . TRP A 1 214 ? 37.610  -23.409 1.652   1.00 43.71  ? 178 TRP A HE1  1 
ATOM   2765 H HE3  . TRP A 1 214 ? 34.665  -23.880 5.784   1.00 49.79  ? 178 TRP A HE3  1 
ATOM   2766 H HZ2  . TRP A 1 214 ? 35.086  -22.325 1.382   1.00 31.71  ? 178 TRP A HZ2  1 
ATOM   2767 H HZ3  . TRP A 1 214 ? 32.893  -22.844 4.711   1.00 46.57  ? 178 TRP A HZ3  1 
ATOM   2768 H HH2  . TRP A 1 214 ? 33.088  -22.138 2.516   1.00 38.95  ? 178 TRP A HH2  1 
ATOM   2769 N N    . LEU A 1 215 ? 39.743  -22.278 5.954   1.00 30.27  ? 179 LEU A N    1 
ATOM   2770 C CA   . LEU A 1 215 ? 41.051  -21.735 5.609   1.00 37.76  ? 179 LEU A CA   1 
ATOM   2771 C C    . LEU A 1 215 ? 41.774  -21.144 6.809   1.00 29.96  ? 179 LEU A C    1 
ATOM   2772 O O    . LEU A 1 215 ? 42.968  -20.846 6.717   1.00 37.31  ? 179 LEU A O    1 
ATOM   2773 C CB   . LEU A 1 215 ? 40.886  -20.680 4.508   1.00 36.71  ? 179 LEU A CB   1 
ATOM   2774 C CG   . LEU A 1 215 ? 40.428  -21.262 3.164   1.00 31.42  ? 179 LEU A CG   1 
ATOM   2775 C CD1  . LEU A 1 215 ? 40.375  -20.182 2.094   1.00 31.50  ? 179 LEU A CD1  1 
ATOM   2776 C CD2  . LEU A 1 215 ? 41.307  -22.419 2.699   1.00 39.20  ? 179 LEU A CD2  1 
ATOM   2777 H H    . LEU A 1 215 ? 39.094  -21.731 5.814   1.00 36.32  ? 179 LEU A H    1 
ATOM   2778 H HA   . LEU A 1 215 ? 41.614  -22.442 5.257   1.00 45.30  ? 179 LEU A HA   1 
ATOM   2779 H HB2  . LEU A 1 215 ? 40.223  -20.033 4.793   1.00 44.04  ? 179 LEU A HB2  1 
ATOM   2780 H HB3  . LEU A 1 215 ? 41.740  -20.242 4.366   1.00 44.04  ? 179 LEU A HB3  1 
ATOM   2781 H HG   . LEU A 1 215 ? 39.535  -21.616 3.295   1.00 37.69  ? 179 LEU A HG   1 
ATOM   2782 H HD11 . LEU A 1 215 ? 40.005  -20.561 1.282   1.00 37.79  ? 179 LEU A HD11 1 
ATOM   2783 H HD12 . LEU A 1 215 ? 39.813  -19.455 2.406   1.00 37.79  ? 179 LEU A HD12 1 
ATOM   2784 H HD13 . LEU A 1 215 ? 41.274  -19.857 1.928   1.00 37.79  ? 179 LEU A HD13 1 
ATOM   2785 H HD21 . LEU A 1 215 ? 41.155  -22.571 1.754   1.00 47.03  ? 179 LEU A HD21 1 
ATOM   2786 H HD22 . LEU A 1 215 ? 42.237  -22.190 2.852   1.00 47.03  ? 179 LEU A HD22 1 
ATOM   2787 H HD23 . LEU A 1 215 ? 41.075  -23.214 3.204   1.00 47.03  ? 179 LEU A HD23 1 
ATOM   2788 N N    . ARG A 1 216 ? 41.098  -20.989 7.931   1.00 33.14  ? 180 ARG A N    1 
ATOM   2789 C CA   . ARG A 1 216 ? 41.684  -20.446 9.141   1.00 40.25  ? 180 ARG A CA   1 
ATOM   2790 C C    . ARG A 1 216 ? 40.947  -21.099 10.306  1.00 35.87  ? 180 ARG A C    1 
ATOM   2791 O O    . ARG A 1 216 ? 40.306  -20.450 11.123  1.00 33.28  ? 180 ARG A O    1 
ATOM   2792 C CB   . ARG A 1 216 ? 41.568  -18.925 9.171   1.00 33.77  ? 180 ARG A CB   1 
ATOM   2793 C CG   . ARG A 1 216 ? 40.174  -18.435 8.820   1.00 33.29  ? 180 ARG A CG   1 
ATOM   2794 C CD   . ARG A 1 216 ? 40.092  -18.049 7.360   1.00 27.09  ? 180 ARG A CD   1 
ATOM   2795 N NE   . ARG A 1 216 ? 38.963  -17.150 7.116   1.00 27.90  ? 180 ARG A NE   1 
ATOM   2796 C CZ   . ARG A 1 216 ? 39.049  -15.828 7.107   1.00 28.78  ? 180 ARG A CZ   1 
ATOM   2797 N NH1  . ARG A 1 216 ? 40.195  -15.206 7.355   1.00 24.25  ? 180 ARG A NH1  1 
ATOM   2798 N NH2  . ARG A 1 216 ? 37.959  -15.108 6.844   1.00 27.47  ? 180 ARG A NH2  1 
ATOM   2799 H H    . ARG A 1 216 ? 40.269  -21.199 8.020   1.00 39.75  ? 180 ARG A H    1 
ATOM   2800 H HA   . ARG A 1 216 ? 42.629  -20.658 9.184   1.00 48.29  ? 180 ARG A HA   1 
ATOM   2801 H HB2  . ARG A 1 216 ? 41.781  -18.609 10.063  1.00 40.52  ? 180 ARG A HB2  1 
ATOM   2802 H HB3  . ARG A 1 216 ? 42.190  -18.548 8.529   1.00 40.52  ? 180 ARG A HB3  1 
ATOM   2803 H HG2  . ARG A 1 216 ? 39.531  -19.142 8.987   1.00 39.94  ? 180 ARG A HG2  1 
ATOM   2804 H HG3  . ARG A 1 216 ? 39.959  -17.657 9.357   1.00 39.94  ? 180 ARG A HG3  1 
ATOM   2805 H HD2  . ARG A 1 216 ? 40.908  -17.594 7.100   1.00 32.50  ? 180 ARG A HD2  1 
ATOM   2806 H HD3  . ARG A 1 216 ? 39.970  -18.846 6.821   1.00 32.50  ? 180 ARG A HD3  1 
ATOM   2807 H HE   . ARG A 1 216 ? 38.192  -17.502 6.969   1.00 33.47  ? 180 ARG A HE   1 
ATOM   2808 H HH11 . ARG A 1 216 ? 40.904  -15.663 7.526   1.00 29.09  ? 180 ARG A HH11 1 
ATOM   2809 H HH12 . ARG A 1 216 ? 40.230  -14.347 7.344   1.00 29.09  ? 180 ARG A HH12 1 
ATOM   2810 H HH21 . ARG A 1 216 ? 37.212  -15.503 6.682   1.00 32.95  ? 180 ARG A HH21 1 
ATOM   2811 H HH22 . ARG A 1 216 ? 38.002  -14.249 6.835   1.00 32.95  ? 180 ARG A HH22 1 
ATOM   2812 N N    . ALA A 1 217 ? 41.039  -22.427 10.379  1.00 39.37  ? 181 ALA A N    1 
ATOM   2813 C CA   . ALA A 1 217 ? 40.091  -23.175 11.197  1.00 34.79  ? 181 ALA A CA   1 
ATOM   2814 C C    . ALA A 1 217 ? 40.272  -22.881 12.675  1.00 40.70  ? 181 ALA A C    1 
ATOM   2815 O O    . ALA A 1 217 ? 39.301  -22.938 13.440  1.00 38.29  ? 181 ALA A O    1 
ATOM   2816 C CB   . ALA A 1 217 ? 40.235  -24.674 10.923  1.00 40.01  ? 181 ALA A CB   1 
ATOM   2817 H H    . ALA A 1 217 ? 41.627  -22.906 9.974   1.00 47.24  ? 181 ALA A H    1 
ATOM   2818 H HA   . ALA A 1 217 ? 39.190  -22.914 10.953  1.00 41.74  ? 181 ALA A HA   1 
ATOM   2819 H HB1  . ALA A 1 217 ? 39.607  -25.159 11.481  1.00 48.01  ? 181 ALA A HB1  1 
ATOM   2820 H HB2  . ALA A 1 217 ? 40.045  -24.844 9.987   1.00 48.01  ? 181 ALA A HB2  1 
ATOM   2821 H HB3  . ALA A 1 217 ? 41.142  -24.948 11.131  1.00 48.01  ? 181 ALA A HB3  1 
ATOM   2822 N N    . ASP A 1 218 ? 41.489  -22.532 13.090  1.00 39.50  ? 182 ASP A N    1 
ATOM   2823 C CA   . ASP A 1 218 ? 41.725  -22.153 14.474  1.00 46.35  ? 182 ASP A CA   1 
ATOM   2824 C C    . ASP A 1 218 ? 41.016  -20.858 14.844  1.00 45.37  ? 182 ASP A C    1 
ATOM   2825 O O    . ASP A 1 218 ? 40.888  -20.558 16.034  1.00 47.81  ? 182 ASP A O    1 
ATOM   2826 C CB   . ASP A 1 218 ? 43.224  -22.016 14.717  1.00 46.12  ? 182 ASP A CB   1 
ATOM   2827 C CG   . ASP A 1 218 ? 43.846  -20.943 13.859  1.00 51.96  ? 182 ASP A CG   1 
ATOM   2828 O OD1  . ASP A 1 218 ? 43.785  -21.078 12.614  1.00 53.80  ? 182 ASP A OD1  1 
ATOM   2829 O OD2  . ASP A 1 218 ? 44.389  -19.966 14.426  1.00 54.12  ? 182 ASP A OD2  1 
ATOM   2830 H H    . ASP A 1 218 ? 42.188  -22.507 12.589  1.00 47.38  ? 182 ASP A H    1 
ATOM   2831 H HA   . ASP A 1 218 ? 41.393  -22.850 15.061  1.00 55.61  ? 182 ASP A HA   1 
ATOM   2832 H HB2  . ASP A 1 218 ? 43.376  -21.785 15.646  1.00 55.34  ? 182 ASP A HB2  1 
ATOM   2833 H HB3  . ASP A 1 218 ? 43.658  -22.858 14.509  1.00 55.34  ? 182 ASP A HB3  1 
ATOM   2834 N N    . LYS A 1 219 ? 40.547  -20.097 13.855  1.00 43.35  ? 183 LYS A N    1 
ATOM   2835 C CA   . LYS A 1 219 ? 39.825  -18.855 14.087  1.00 39.66  ? 183 LYS A CA   1 
ATOM   2836 C C    . LYS A 1 219 ? 38.346  -18.986 13.765  1.00 40.58  ? 183 LYS A C    1 
ATOM   2837 O O    . LYS A 1 219 ? 37.669  -17.970 13.584  1.00 36.54  ? 183 LYS A O    1 
ATOM   2838 C CB   . LYS A 1 219 ? 40.425  -17.718 13.258  1.00 43.93  ? 183 LYS A CB   1 
ATOM   2839 C CG   . LYS A 1 219 ? 41.935  -17.573 13.368  1.00 45.96  ? 183 LYS A CG   1 
ATOM   2840 C CD   . LYS A 1 219 ? 42.504  -16.701 12.254  1.00 55.33  ? 183 LYS A CD   1 
ATOM   2841 C CE   . LYS A 1 219 ? 43.500  -15.671 12.802  1.00 60.29  ? 183 LYS A CE   1 
ATOM   2842 N NZ   . LYS A 1 219 ? 42.852  -14.365 13.149  1.00 60.28  ? 183 LYS A NZ   1 
ATOM   2843 H H    . LYS A 1 219 ? 40.639  -20.287 13.021  1.00 52.01  ? 183 LYS A H    1 
ATOM   2844 H HA   . LYS A 1 219 ? 39.917  -18.629 15.026  1.00 47.58  ? 183 LYS A HA   1 
ATOM   2845 H HB2  . LYS A 1 219 ? 40.215  -17.874 12.324  1.00 52.71  ? 183 LYS A HB2  1 
ATOM   2846 H HB3  . LYS A 1 219 ? 40.030  -16.882 13.552  1.00 52.71  ? 183 LYS A HB3  1 
ATOM   2847 H HG2  . LYS A 1 219 ? 42.156  -17.161 14.218  1.00 55.14  ? 183 LYS A HG2  1 
ATOM   2848 H HG3  . LYS A 1 219 ? 42.346  -18.449 13.308  1.00 55.14  ? 183 LYS A HG3  1 
ATOM   2849 H HD2  . LYS A 1 219 ? 42.968  -17.262 11.612  1.00 66.39  ? 183 LYS A HD2  1 
ATOM   2850 H HD3  . LYS A 1 219 ? 41.781  -16.225 11.817  1.00 66.39  ? 183 LYS A HD3  1 
ATOM   2851 H HE2  . LYS A 1 219 ? 43.910  -16.025 13.607  1.00 72.34  ? 183 LYS A HE2  1 
ATOM   2852 H HE3  . LYS A 1 219 ? 44.179  -15.499 12.131  1.00 72.34  ? 183 LYS A HE3  1 
ATOM   2853 H HZ1  . LYS A 1 219 ? 43.457  -13.804 13.483  1.00 72.32  ? 183 LYS A HZ1  1 
ATOM   2854 H HZ2  . LYS A 1 219 ? 42.491  -14.002 12.421  1.00 72.32  ? 183 LYS A HZ2  1 
ATOM   2855 H HZ3  . LYS A 1 219 ? 42.212  -14.494 13.754  1.00 72.32  ? 183 LYS A HZ3  1 
ATOM   2856 N N    . SER A 1 220 ? 37.829  -20.217 13.699  1.00 40.57  ? 184 SER A N    1 
ATOM   2857 C CA   . SER A 1 220 ? 36.453  -20.419 13.257  1.00 39.42  ? 184 SER A CA   1 
ATOM   2858 C C    . SER A 1 220 ? 35.472  -19.621 14.102  1.00 35.81  ? 184 SER A C    1 
ATOM   2859 O O    . SER A 1 220 ? 34.536  -19.013 13.573  1.00 37.91  ? 184 SER A O    1 
ATOM   2860 C CB   . SER A 1 220 ? 36.096  -21.908 13.296  1.00 41.68  ? 184 SER A CB   1 
ATOM   2861 O OG   . SER A 1 220 ? 36.458  -22.484 14.538  1.00 53.47  ? 184 SER A OG   1 
ATOM   2862 H H    . SER A 1 220 ? 38.249  -20.940 13.902  1.00 48.68  ? 184 SER A H    1 
ATOM   2863 H HA   . SER A 1 220 ? 36.379  -20.113 12.339  1.00 47.29  ? 184 SER A HA   1 
ATOM   2864 H HB2  . SER A 1 220 ? 35.140  -22.006 13.170  1.00 50.00  ? 184 SER A HB2  1 
ATOM   2865 H HB3  . SER A 1 220 ? 36.573  -22.365 12.586  1.00 50.00  ? 184 SER A HB3  1 
ATOM   2866 H HG   . SER A 1 220 ? 36.253  -23.299 14.547  1.00 64.15  ? 184 SER A HG   1 
ATOM   2867 N N    . GLU A 1 221 ? 35.654  -19.608 15.418  1.00 37.19  ? 185 GLU A N    1 
ATOM   2868 C CA   . GLU A 1 221 ? 34.708  -18.872 16.248  1.00 39.44  ? 185 GLU A CA   1 
ATOM   2869 C C    . GLU A 1 221 ? 34.806  -17.379 15.981  1.00 32.78  ? 185 GLU A C    1 
ATOM   2870 O O    . GLU A 1 221 ? 33.788  -16.680 15.966  1.00 32.61  ? 185 GLU A O    1 
ATOM   2871 C CB   . GLU A 1 221 ? 34.934  -19.167 17.734  1.00 49.32  ? 185 GLU A CB   1 
ATOM   2872 C CG   . GLU A 1 221 ? 35.232  -20.634 18.056  1.00 59.53  ? 185 GLU A CG   1 
ATOM   2873 C CD   . GLU A 1 221 ? 34.121  -21.307 18.844  1.00 70.32  ? 185 GLU A CD   1 
ATOM   2874 O OE1  . GLU A 1 221 ? 33.007  -20.736 18.921  1.00 70.95  ? 185 GLU A OE1  1 
ATOM   2875 O OE2  . GLU A 1 221 ? 34.363  -22.412 19.381  1.00 67.73  ? 185 GLU A OE2  1 
ATOM   2876 H H    . GLU A 1 221 ? 36.292  -20.002 15.839  1.00 44.62  ? 185 GLU A H    1 
ATOM   2877 H HA   . GLU A 1 221 ? 33.811  -19.170 16.030  1.00 47.31  ? 185 GLU A HA   1 
ATOM   2878 H HB2  . GLU A 1 221 ? 35.689  -18.641 18.041  1.00 59.18  ? 185 GLU A HB2  1 
ATOM   2879 H HB3  . GLU A 1 221 ? 34.134  -18.917 18.223  1.00 59.18  ? 185 GLU A HB3  1 
ATOM   2880 H HG2  . GLU A 1 221 ? 35.348  -21.122 17.226  1.00 71.42  ? 185 GLU A HG2  1 
ATOM   2881 H HG3  . GLU A 1 221 ? 36.044  -20.682 18.585  1.00 71.42  ? 185 GLU A HG3  1 
ATOM   2882 N N    . ASP A 1 222 ? 36.024  -16.869 15.776  1.00 32.64  ? 186 ASP A N    1 
ATOM   2883 C CA   . ASP A 1 222 ? 36.174  -15.467 15.409  1.00 31.59  ? 186 ASP A CA   1 
ATOM   2884 C C    . ASP A 1 222 ? 35.486  -15.177 14.075  1.00 25.42  ? 186 ASP A C    1 
ATOM   2885 O O    . ASP A 1 222 ? 34.882  -14.117 13.903  1.00 22.35  ? 186 ASP A O    1 
ATOM   2886 C CB   . ASP A 1 222 ? 37.654  -15.084 15.305  1.00 34.68  ? 186 ASP A CB   1 
ATOM   2887 C CG   . ASP A 1 222 ? 38.413  -15.183 16.626  1.00 39.59  ? 186 ASP A CG   1 
ATOM   2888 O OD1  . ASP A 1 222 ? 37.843  -14.935 17.712  1.00 38.56  ? 186 ASP A OD1  1 
ATOM   2889 O OD2  . ASP A 1 222 ? 39.624  -15.458 16.553  1.00 42.89  ? 186 ASP A OD2  1 
ATOM   2890 H H    . ASP A 1 222 ? 36.761  -17.307 15.842  1.00 39.16  ? 186 ASP A H    1 
ATOM   2891 H HA   . ASP A 1 222 ? 35.768  -14.930 16.108  1.00 37.90  ? 186 ASP A HA   1 
ATOM   2892 H HB2  . ASP A 1 222 ? 38.086  -15.678 14.671  1.00 41.61  ? 186 ASP A HB2  1 
ATOM   2893 H HB3  . ASP A 1 222 ? 37.718  -14.166 14.996  1.00 41.61  ? 186 ASP A HB3  1 
ATOM   2894 N N    . VAL A 1 223 ? 35.608  -16.093 13.109  1.00 28.30  ? 187 VAL A N    1 
ATOM   2895 C CA   . VAL A 1 223 ? 34.947  -15.915 11.811  1.00 29.68  ? 187 VAL A CA   1 
ATOM   2896 C C    . VAL A 1 223 ? 33.437  -15.816 12.011  1.00 25.73  ? 187 VAL A C    1 
ATOM   2897 O O    . VAL A 1 223 ? 32.786  -14.870 11.547  1.00 24.34  ? 187 VAL A O    1 
ATOM   2898 C CB   . VAL A 1 223 ? 35.345  -17.055 10.851  1.00 25.61  ? 187 VAL A CB   1 
ATOM   2899 C CG1  . VAL A 1 223 ? 34.593  -16.994 9.546   1.00 27.94  ? 187 VAL A CG1  1 
ATOM   2900 C CG2  . VAL A 1 223 ? 36.854  -17.000 10.534  1.00 29.42  ? 187 VAL A CG2  1 
ATOM   2901 H H    . VAL A 1 223 ? 36.063  -16.820 13.178  1.00 33.95  ? 187 VAL A H    1 
ATOM   2902 H HA   . VAL A 1 223 ? 35.244  -15.085 11.407  1.00 35.61  ? 187 VAL A HA   1 
ATOM   2903 H HB   . VAL A 1 223 ? 35.122  -17.884 11.302  1.00 30.72  ? 187 VAL A HB   1 
ATOM   2904 H HG11 . VAL A 1 223 ? 34.981  -17.634 8.928   1.00 33.51  ? 187 VAL A HG11 1 
ATOM   2905 H HG12 . VAL A 1 223 ? 33.662  -17.213 9.707   1.00 33.51  ? 187 VAL A HG12 1 
ATOM   2906 H HG13 . VAL A 1 223 ? 34.664  -16.098 9.182   1.00 33.51  ? 187 VAL A HG13 1 
ATOM   2907 H HG21 . VAL A 1 223 ? 37.093  -17.774 10.001  1.00 35.29  ? 187 VAL A HG21 1 
ATOM   2908 H HG22 . VAL A 1 223 ? 37.043  -16.187 10.040  1.00 35.29  ? 187 VAL A HG22 1 
ATOM   2909 H HG23 . VAL A 1 223 ? 37.352  -17.005 11.366  1.00 35.29  ? 187 VAL A HG23 1 
ATOM   2910 N N    . GLN A 1 224 ? 32.860  -16.745 12.774  1.00 25.74  ? 188 GLN A N    1 
ATOM   2911 C CA   . GLN A 1 224 ? 31.426  -16.658 13.039  1.00 29.71  ? 188 GLN A CA   1 
ATOM   2912 C C    . GLN A 1 224 ? 31.062  -15.337 13.704  1.00 28.00  ? 188 GLN A C    1 
ATOM   2913 O O    . GLN A 1 224 ? 30.051  -14.722 13.362  1.00 24.27  ? 188 GLN A O    1 
ATOM   2914 C CB   . GLN A 1 224 ? 30.957  -17.831 13.901  1.00 33.78  ? 188 GLN A CB   1 
ATOM   2915 C CG   . GLN A 1 224 ? 31.549  -19.153 13.506  1.00 34.97  ? 188 GLN A CG   1 
ATOM   2916 C CD   . GLN A 1 224 ? 30.925  -20.352 14.222  1.00 46.05  ? 188 GLN A CD   1 
ATOM   2917 O OE1  . GLN A 1 224 ? 30.165  -20.216 15.190  1.00 50.69  ? 188 GLN A OE1  1 
ATOM   2918 N NE2  . GLN A 1 224 ? 31.261  -21.537 13.742  1.00 35.36  ? 188 GLN A NE2  1 
ATOM   2919 H H    . GLN A 1 224 ? 33.263  -17.413 13.137  1.00 30.88  ? 188 GLN A H    1 
ATOM   2920 H HA   . GLN A 1 224 ? 30.961  -16.712 12.189  1.00 35.64  ? 188 GLN A HA   1 
ATOM   2921 H HB2  . GLN A 1 224 ? 31.206  -17.659 14.822  1.00 40.53  ? 188 GLN A HB2  1 
ATOM   2922 H HB3  . GLN A 1 224 ? 29.993  -17.906 13.826  1.00 40.53  ? 188 GLN A HB3  1 
ATOM   2923 H HG2  . GLN A 1 224 ? 31.421  -19.279 12.553  1.00 41.95  ? 188 GLN A HG2  1 
ATOM   2924 H HG3  . GLN A 1 224 ? 32.496  -19.144 13.716  1.00 41.95  ? 188 GLN A HG3  1 
ATOM   2925 H HE21 . GLN A 1 224 ? 31.796  -21.594 13.071  1.00 42.42  ? 188 GLN A HE21 1 
ATOM   2926 H HE22 . GLN A 1 224 ? 30.944  -22.252 14.100  1.00 42.42  ? 188 GLN A HE22 1 
ATOM   2927 N N    . LYS A 1 225 ? 31.866  -14.890 14.675  1.00 25.85  ? 189 LYS A N    1 
ATOM   2928 C CA   . LYS A 1 225 ? 31.595  -13.616 15.326  1.00 26.41  ? 189 LYS A CA   1 
ATOM   2929 C C    . LYS A 1 225 ? 31.731  -12.449 14.355  1.00 21.53  ? 189 LYS A C    1 
ATOM   2930 O O    . LYS A 1 225 ? 30.918  -11.521 14.373  1.00 23.72  ? 189 LYS A O    1 
ATOM   2931 C CB   . LYS A 1 225 ? 32.546  -13.428 16.514  1.00 31.38  ? 189 LYS A CB   1 
ATOM   2932 C CG   . LYS A 1 225 ? 32.525  -12.039 17.092  1.00 40.78  ? 189 LYS A CG   1 
ATOM   2933 C CD   . LYS A 1 225 ? 33.380  -11.929 18.350  1.00 47.43  ? 189 LYS A CD   1 
ATOM   2934 C CE   . LYS A 1 225 ? 33.304  -10.517 18.919  1.00 58.53  ? 189 LYS A CE   1 
ATOM   2935 N NZ   . LYS A 1 225 ? 32.400  -10.434 20.116  1.00 72.62  ? 189 LYS A NZ   1 
ATOM   2936 H H    . LYS A 1 225 ? 32.563  -15.301 14.967  1.00 31.01  ? 189 LYS A H    1 
ATOM   2937 H HA   . LYS A 1 225 ? 30.683  -13.625 15.656  1.00 31.68  ? 189 LYS A HA   1 
ATOM   2938 H HB2  . LYS A 1 225 ? 32.292  -14.046 17.218  1.00 37.65  ? 189 LYS A HB2  1 
ATOM   2939 H HB3  . LYS A 1 225 ? 33.452  -13.614 16.221  1.00 37.65  ? 189 LYS A HB3  1 
ATOM   2940 H HG2  . LYS A 1 225 ? 32.872  -11.415 16.435  1.00 48.93  ? 189 LYS A HG2  1 
ATOM   2941 H HG3  . LYS A 1 225 ? 31.613  -11.804 17.324  1.00 48.93  ? 189 LYS A HG3  1 
ATOM   2942 H HD2  . LYS A 1 225 ? 33.054  -12.551 19.020  1.00 56.90  ? 189 LYS A HD2  1 
ATOM   2943 H HD3  . LYS A 1 225 ? 34.304  -12.127 18.135  1.00 56.90  ? 189 LYS A HD3  1 
ATOM   2944 H HE2  . LYS A 1 225 ? 34.192  -10.236 19.191  1.00 70.23  ? 189 LYS A HE2  1 
ATOM   2945 H HE3  . LYS A 1 225 ? 32.961  -9.918  18.239  1.00 70.23  ? 189 LYS A HE3  1 
ATOM   2946 H HZ1  . LYS A 1 225 ? 32.375  -9.599  20.422  1.00 87.13  ? 189 LYS A HZ1  1 
ATOM   2947 H HZ2  . LYS A 1 225 ? 31.575  -10.684 19.892  1.00 87.13  ? 189 LYS A HZ2  1 
ATOM   2948 H HZ3  . LYS A 1 225 ? 32.698  -10.970 20.761  1.00 87.13  ? 189 LYS A HZ3  1 
ATOM   2949 N N    . ALA A 1 226 ? 32.791  -12.451 13.545  1.00 26.33  ? 190 ALA A N    1 
ATOM   2950 C CA   . ALA A 1 226 ? 32.979  -11.394 12.565  1.00 23.46  ? 190 ALA A CA   1 
ATOM   2951 C C    . ALA A 1 226 ? 31.825  -11.348 11.567  1.00 22.64  ? 190 ALA A C    1 
ATOM   2952 O O    . ALA A 1 226 ? 31.378  -10.267 11.182  1.00 21.30  ? 190 ALA A O    1 
ATOM   2953 C CB   . ALA A 1 226 ? 34.301  -11.592 11.826  1.00 23.36  ? 190 ALA A CB   1 
ATOM   2954 H H    . ALA A 1 226 ? 33.409  -13.049 13.546  1.00 31.59  ? 190 ALA A H    1 
ATOM   2955 H HA   . ALA A 1 226 ? 33.013  -10.544 13.032  1.00 28.14  ? 190 ALA A HA   1 
ATOM   2956 H HB1  . ALA A 1 226 ? 34.413  -10.876 11.181  1.00 28.02  ? 190 ALA A HB1  1 
ATOM   2957 H HB2  . ALA A 1 226 ? 35.027  -11.574 12.469  1.00 28.02  ? 190 ALA A HB2  1 
ATOM   2958 H HB3  . ALA A 1 226 ? 34.283  -12.448 11.371  1.00 28.02  ? 190 ALA A HB3  1 
ATOM   2959 N N    . MET A 1 227 ? 31.330  -12.486 11.142  1.00 22.46  ? 191 MET A N    1 
ATOM   2960 C CA   . MET A 1 227 ? 30.235  -12.498 10.200  1.00 21.47  ? 191 MET A CA   1 
ATOM   2961 C C    . MET A 1 227 ? 29.032  -11.816 10.804  1.00 18.14  ? 191 MET A C    1 
ATOM   2962 O O    . MET A 1 227 ? 28.353  -11.067 10.156  1.00 22.44  ? 191 MET A O    1 
ATOM   2963 C CB   . MET A 1 227 ? 29.859  -13.913 9.813   1.00 22.92  ? 191 MET A CB   1 
ATOM   2964 C CG   . MET A 1 227 ? 28.835  -14.000 8.706   1.00 24.98  ? 191 MET A CG   1 
ATOM   2965 S SD   . MET A 1 227 ? 29.434  -13.399 7.118   1.00 25.55  ? 191 MET A SD   1 
ATOM   2966 C CE   . MET A 1 227 ? 27.885  -13.377 6.229   1.00 29.79  ? 191 MET A CE   1 
ATOM   2967 H H    . MET A 1 227 ? 31.598  -13.271 11.378  1.00 26.94  ? 191 MET A H    1 
ATOM   2968 H HA   . MET A 1 227 ? 30.505  -12.018 9.391   1.00 25.75  ? 191 MET A HA   1 
ATOM   2969 H HB2  . MET A 1 227 ? 30.659  -14.374 9.519   1.00 27.49  ? 191 MET A HB2  1 
ATOM   2970 H HB3  . MET A 1 227 ? 29.493  -14.354 10.595  1.00 27.49  ? 191 MET A HB3  1 
ATOM   2971 H HG2  . MET A 1 227 ? 28.580  -14.929 8.590   1.00 29.97  ? 191 MET A HG2  1 
ATOM   2972 H HG3  . MET A 1 227 ? 28.057  -13.474 8.948   1.00 29.97  ? 191 MET A HG3  1 
ATOM   2973 H HE1  . MET A 1 227 ? 28.000  -12.889 5.408   1.00 35.73  ? 191 MET A HE1  1 
ATOM   2974 H HE2  . MET A 1 227 ? 27.619  -14.279 6.038   1.00 35.73  ? 191 MET A HE2  1 
ATOM   2975 H HE3  . MET A 1 227 ? 27.220  -12.949 6.775   1.00 35.73  ? 191 MET A HE3  1 
ATOM   2976 N N    . GLY A 1 228 ? 28.794  -12.067 12.080  1.00 20.62  ? 192 GLY A N    1 
ATOM   2977 C CA   . GLY A 1 228 ? 27.681  -11.401 12.720  1.00 24.53  ? 192 GLY A CA   1 
ATOM   2978 C C    . GLY A 1 228 ? 27.891  -9.911  12.793  1.00 23.91  ? 192 GLY A C    1 
ATOM   2979 O O    . GLY A 1 228 ? 26.967  -9.132  12.597  1.00 20.45  ? 192 GLY A O    1 
ATOM   2980 H H    . GLY A 1 228 ? 29.246  -12.595 12.586  1.00 24.73  ? 192 GLY A H    1 
ATOM   2981 H HA2  . GLY A 1 228 ? 26.868  -11.574 12.220  1.00 29.43  ? 192 GLY A HA2  1 
ATOM   2982 H HA3  . GLY A 1 228 ? 27.575  -11.743 13.622  1.00 29.43  ? 192 GLY A HA3  1 
ATOM   2983 N N    . GLU A 1 229 ? 29.120  -9.489  13.088  1.00 23.19  ? 193 GLU A N    1 
ATOM   2984 C CA   . GLU A 1 229 ? 29.411  -8.073  13.093  1.00 17.18  ? 193 GLU A CA   1 
ATOM   2985 C C    . GLU A 1 229 ? 29.149  -7.470  11.724  1.00 18.07  ? 193 GLU A C    1 
ATOM   2986 O O    . GLU A 1 229 ? 28.544  -6.401  11.613  1.00 20.85  ? 193 GLU A O    1 
ATOM   2987 C CB   . GLU A 1 229 ? 30.866  -7.857  13.532  1.00 19.74  ? 193 GLU A CB   1 
ATOM   2988 C CG   . GLU A 1 229 ? 30.982  -7.906  15.068  1.00 27.90  ? 193 GLU A CG   1 
ATOM   2989 C CD   . GLU A 1 229 ? 32.404  -8.118  15.562  1.00 36.71  ? 193 GLU A CD   1 
ATOM   2990 O OE1  . GLU A 1 229 ? 33.323  -8.241  14.729  1.00 35.39  ? 193 GLU A OE1  1 
ATOM   2991 O OE2  . GLU A 1 229 ? 32.590  -8.188  16.786  1.00 37.45  ? 193 GLU A OE2  1 
ATOM   2992 H H    . GLU A 1 229 ? 29.785  -9.998  13.285  1.00 27.82  ? 193 GLU A H    1 
ATOM   2993 H HA   . GLU A 1 229 ? 28.839  -7.617  13.730  1.00 20.60  ? 193 GLU A HA   1 
ATOM   2994 H HB2  . GLU A 1 229 ? 31.424  -8.555  13.157  1.00 23.68  ? 193 GLU A HB2  1 
ATOM   2995 H HB3  . GLU A 1 229 ? 31.171  -6.988  13.226  1.00 23.68  ? 193 GLU A HB3  1 
ATOM   2996 H HG2  . GLU A 1 229 ? 30.664  -7.066  15.434  1.00 33.46  ? 193 GLU A HG2  1 
ATOM   2997 H HG3  . GLU A 1 229 ? 30.440  -8.639  15.400  1.00 33.46  ? 193 GLU A HG3  1 
ATOM   2998 N N    . MET A 1 230 ? 29.592  -8.137  10.671  1.00 17.82  ? 194 MET A N    1 
ATOM   2999 C CA   . MET A 1 230 ? 29.413  -7.564  9.342   1.00 16.52  ? 194 MET A CA   1 
ATOM   3000 C C    . MET A 1 230 ? 27.927  -7.424  9.006   1.00 17.23  ? 194 MET A C    1 
ATOM   3001 O O    . MET A 1 230 ? 27.501  -6.429  8.409   1.00 20.59  ? 194 MET A O    1 
ATOM   3002 C CB   . MET A 1 230 ? 30.082  -8.415  8.292   1.00 17.91  ? 194 MET A CB   1 
ATOM   3003 C CG   . MET A 1 230 ? 30.056  -7.837  6.876   1.00 21.19  ? 194 MET A CG   1 
ATOM   3004 S SD   . MET A 1 230 ? 31.436  -8.388  5.836   1.00 18.43  ? 194 MET A SD   1 
ATOM   3005 C CE   . MET A 1 230 ? 30.602  -9.885  5.182   1.00 17.26  ? 194 MET A CE   1 
ATOM   3006 H H    . MET A 1 230 ? 29.987  -8.901  10.694  1.00 21.37  ? 194 MET A H    1 
ATOM   3007 H HA   . MET A 1 230 ? 29.841  -6.694  9.336   1.00 19.81  ? 194 MET A HA   1 
ATOM   3008 H HB2  . MET A 1 230 ? 31.013  -8.533  8.540   1.00 21.48  ? 194 MET A HB2  1 
ATOM   3009 H HB3  . MET A 1 230 ? 29.635  -9.275  8.263   1.00 21.48  ? 194 MET A HB3  1 
ATOM   3010 H HG2  . MET A 1 230 ? 29.232  -8.111  6.443   1.00 25.41  ? 194 MET A HG2  1 
ATOM   3011 H HG3  . MET A 1 230 ? 30.096  -6.870  6.932   1.00 25.41  ? 194 MET A HG3  1 
ATOM   3012 H HE1  . MET A 1 230 ? 31.146  -10.266 4.474   1.00 20.70  ? 194 MET A HE1  1 
ATOM   3013 H HE2  . MET A 1 230 ? 30.497  -10.528 5.901   1.00 20.70  ? 194 MET A HE2  1 
ATOM   3014 H HE3  . MET A 1 230 ? 29.733  -9.635  4.832   1.00 20.70  ? 194 MET A HE3  1 
ATOM   3015 N N    . MET A 1 231 ? 27.141  -8.441  9.331   1.00 21.71  ? 195 MET A N    1 
ATOM   3016 C CA   . MET A 1 231 ? 25.709  -8.346  9.050   1.00 21.46  ? 195 MET A CA   1 
ATOM   3017 C C    . MET A 1 231 ? 25.070  -7.235  9.865   1.00 21.55  ? 195 MET A C    1 
ATOM   3018 O O    . MET A 1 231 ? 24.224  -6.499  9.356   1.00 21.43  ? 195 MET A O    1 
ATOM   3019 C CB   . MET A 1 231 ? 25.025  -9.666  9.340   1.00 15.49  ? 195 MET A CB   1 
ATOM   3020 C CG   . MET A 1 231 ? 25.270  -10.788 8.395   1.00 20.26  ? 195 MET A CG   1 
ATOM   3021 S SD   . MET A 1 231 ? 25.300  -10.466 6.667   1.00 20.29  ? 195 MET A SD   1 
ATOM   3022 C CE   . MET A 1 231 ? 27.139  -9.963  6.480   1.00 21.28  ? 195 MET A CE   1 
ATOM   3023 H H    . MET A 1 231 ? 27.399  -9.173  9.703   1.00 26.04  ? 195 MET A H    1 
ATOM   3024 H HA   . MET A 1 231 ? 25.596  -8.156  8.105   1.00 25.74  ? 195 MET A HA   1 
ATOM   3025 H HB2  . MET A 1 231 ? 25.318  -9.967  10.214  1.00 18.58  ? 195 MET A HB2  1 
ATOM   3026 H HB3  . MET A 1 231 ? 24.068  -9.509  9.346   1.00 18.58  ? 195 MET A HB3  1 
ATOM   3027 H HG2  . MET A 1 231 ? 26.134  -11.170 8.616   1.00 24.30  ? 195 MET A HG2  1 
ATOM   3028 H HG3  . MET A 1 231 ? 24.570  -11.445 8.537   1.00 24.30  ? 195 MET A HG3  1 
ATOM   3029 H HE1  . MET A 1 231 ? 27.331  -9.811  5.541   1.00 25.52  ? 195 MET A HE1  1 
ATOM   3030 H HE2  . MET A 1 231 ? 27.298  -9.152  6.986   1.00 25.52  ? 195 MET A HE2  1 
ATOM   3031 H HE3  . MET A 1 231 ? 27.698  -10.680 6.819   1.00 25.52  ? 195 MET A HE3  1 
ATOM   3032 N N    . ALA A 1 232 ? 25.453  -7.090  11.138  1.00 22.32  ? 196 ALA A N    1 
ATOM   3033 C CA   . ALA A 1 232 ? 24.861  -6.022  11.944  1.00 20.42  ? 196 ALA A CA   1 
ATOM   3034 C C    . ALA A 1 232 ? 25.209  -4.662  11.372  1.00 21.47  ? 196 ALA A C    1 
ATOM   3035 O O    . ALA A 1 232 ? 24.387  -3.746  11.390  1.00 19.50  ? 196 ALA A O    1 
ATOM   3036 C CB   . ALA A 1 232 ? 25.320  -6.130  13.410  1.00 23.32  ? 196 ALA A CB   1 
ATOM   3037 H H    . ALA A 1 232 ? 26.032  -7.579  11.544  1.00 26.77  ? 196 ALA A H    1 
ATOM   3038 H HA   . ALA A 1 232 ? 23.896  -6.122  11.935  1.00 24.49  ? 196 ALA A HA   1 
ATOM   3039 H HB1  . ALA A 1 232 ? 24.881  -5.439  13.930  1.00 27.97  ? 196 ALA A HB1  1 
ATOM   3040 H HB2  . ALA A 1 232 ? 25.080  -7.005  13.752  1.00 27.97  ? 196 ALA A HB2  1 
ATOM   3041 H HB3  . ALA A 1 232 ? 26.282  -6.012  13.449  1.00 27.97  ? 196 ALA A HB3  1 
ATOM   3042 N N    . LEU A 1 233 ? 26.433  -4.506  10.854  1.00 21.24  ? 197 LEU A N    1 
ATOM   3043 C CA   . LEU A 1 233 ? 26.765  -3.252  10.191  1.00 18.38  ? 197 LEU A CA   1 
ATOM   3044 C C    . LEU A 1 233 ? 25.836  -3.002  9.008   1.00 20.13  ? 197 LEU A C    1 
ATOM   3045 O O    . LEU A 1 233 ? 25.335  -1.891  8.806   1.00 19.59  ? 197 LEU A O    1 
ATOM   3046 C CB   . LEU A 1 233 ? 28.207  -3.289  9.685   1.00 21.03  ? 197 LEU A CB   1 
ATOM   3047 C CG   . LEU A 1 233 ? 29.296  -3.220  10.750  1.00 23.73  ? 197 LEU A CG   1 
ATOM   3048 C CD1  . LEU A 1 233 ? 30.661  -3.430  10.117  1.00 24.81  ? 197 LEU A CD1  1 
ATOM   3049 C CD2  . LEU A 1 233 ? 29.229  -1.861  11.417  1.00 24.96  ? 197 LEU A CD2  1 
ATOM   3050 H H    . LEU A 1 233 ? 27.063  -5.091  10.875  1.00 25.48  ? 197 LEU A H    1 
ATOM   3051 H HA   . LEU A 1 233 ? 26.671  -2.533  10.836  1.00 22.04  ? 197 LEU A HA   1 
ATOM   3052 H HB2  . LEU A 1 233 ? 28.335  -4.118  9.198   1.00 25.22  ? 197 LEU A HB2  1 
ATOM   3053 H HB3  . LEU A 1 233 ? 28.339  -2.532  9.092   1.00 25.22  ? 197 LEU A HB3  1 
ATOM   3054 H HG   . LEU A 1 233 ? 29.166  -3.915  11.415  1.00 28.46  ? 197 LEU A HG   1 
ATOM   3055 H HD11 . LEU A 1 233 ? 31.344  -3.333  10.800  1.00 29.76  ? 197 LEU A HD11 1 
ATOM   3056 H HD12 . LEU A 1 233 ? 30.699  -4.321  9.735   1.00 29.76  ? 197 LEU A HD12 1 
ATOM   3057 H HD13 . LEU A 1 233 ? 30.792  -2.766  9.422   1.00 29.76  ? 197 LEU A HD13 1 
ATOM   3058 H HD21 . LEU A 1 233 ? 29.997  -1.758  12.001  1.00 29.94  ? 197 LEU A HD21 1 
ATOM   3059 H HD22 . LEU A 1 233 ? 29.238  -1.173  10.734  1.00 29.94  ? 197 LEU A HD22 1 
ATOM   3060 H HD23 . LEU A 1 233 ? 28.411  -1.803  11.934  1.00 29.94  ? 197 LEU A HD23 1 
ATOM   3061 N N    . LEU A 1 234 ? 25.643  -4.030  8.183   1.00 19.38  ? 198 LEU A N    1 
ATOM   3062 C CA   . LEU A 1 234 ? 24.818  -3.881  6.990   1.00 15.44  ? 198 LEU A CA   1 
ATOM   3063 C C    . LEU A 1 234 ? 23.382  -3.538  7.369   1.00 19.36  ? 198 LEU A C    1 
ATOM   3064 O O    . LEU A 1 234 ? 22.780  -2.592  6.835   1.00 19.57  ? 198 LEU A O    1 
ATOM   3065 C CB   . LEU A 1 234 ? 24.844  -5.180  6.199   1.00 18.70  ? 198 LEU A CB   1 
ATOM   3066 C CG   . LEU A 1 234 ? 23.906  -5.235  4.981   1.00 14.82  ? 198 LEU A CG   1 
ATOM   3067 C CD1  . LEU A 1 234 ? 24.150  -4.051  4.056   1.00 17.61  ? 198 LEU A CD1  1 
ATOM   3068 C CD2  . LEU A 1 234 ? 24.063  -6.546  4.298   1.00 16.22  ? 198 LEU A CD2  1 
ATOM   3069 H H    . LEU A 1 234 ? 25.976  -4.816  8.290   1.00 23.25  ? 198 LEU A H    1 
ATOM   3070 H HA   . LEU A 1 234 ? 25.174  -3.165  6.441   1.00 18.52  ? 198 LEU A HA   1 
ATOM   3071 H HB2  . LEU A 1 234 ? 25.747  -5.319  5.874   1.00 22.43  ? 198 LEU A HB2  1 
ATOM   3072 H HB3  . LEU A 1 234 ? 24.590  -5.903  6.793   1.00 22.43  ? 198 LEU A HB3  1 
ATOM   3073 H HG   . LEU A 1 234 ? 22.980  -5.165  5.262   1.00 17.77  ? 198 LEU A HG   1 
ATOM   3074 H HD11 . LEU A 1 234 ? 23.645  -4.179  3.238   1.00 21.12  ? 198 LEU A HD11 1 
ATOM   3075 H HD12 . LEU A 1 234 ? 23.860  -3.238  4.500   1.00 21.12  ? 198 LEU A HD12 1 
ATOM   3076 H HD13 . LEU A 1 234 ? 25.098  -3.997  3.854   1.00 21.12  ? 198 LEU A HD13 1 
ATOM   3077 H HD21 . LEU A 1 234 ? 23.446  -6.588  3.550   1.00 19.45  ? 198 LEU A HD21 1 
ATOM   3078 H HD22 . LEU A 1 234 ? 24.975  -6.629  3.979   1.00 19.45  ? 198 LEU A HD22 1 
ATOM   3079 H HD23 . LEU A 1 234 ? 23.867  -7.257  4.928   1.00 19.45  ? 198 LEU A HD23 1 
ATOM   3080 N N    . LYS A 1 235 ? 22.815  -4.326  8.280   1.00 22.90  ? 199 LYS A N    1 
ATOM   3081 C CA   . LYS A 1 235 ? 21.452  -4.054  8.715   1.00 25.21  ? 199 LYS A CA   1 
ATOM   3082 C C    . LYS A 1 235 ? 21.304  -2.601  9.125   1.00 21.29  ? 199 LYS A C    1 
ATOM   3083 O O    . LYS A 1 235 ? 20.308  -1.946  8.793   1.00 25.11  ? 199 LYS A O    1 
ATOM   3084 C CB   . LYS A 1 235 ? 21.082  -4.989  9.848   1.00 25.20  ? 199 LYS A CB   1 
ATOM   3085 C CG   . LYS A 1 235 ? 19.663  -4.812  10.328  1.00 29.61  ? 199 LYS A CG   1 
ATOM   3086 C CD   . LYS A 1 235 ? 18.697  -5.325  9.286   1.00 25.45  ? 199 LYS A CD   1 
ATOM   3087 C CE   . LYS A 1 235 ? 17.262  -5.256  9.796   1.00 28.97  ? 199 LYS A CE   1 
ATOM   3088 N NZ   . LYS A 1 235 ? 16.322  -5.125  8.673   1.00 23.89  ? 199 LYS A NZ   1 
ATOM   3089 H H    . LYS A 1 235 ? 23.188  -5.007  8.650   1.00 27.47  ? 199 LYS A H    1 
ATOM   3090 H HA   . LYS A 1 235 ? 20.833  -4.221  7.986   1.00 30.24  ? 199 LYS A HA   1 
ATOM   3091 H HB2  . LYS A 1 235 ? 21.182  -5.905  9.545   1.00 30.24  ? 199 LYS A HB2  1 
ATOM   3092 H HB3  . LYS A 1 235 ? 21.673  -4.822  10.599  1.00 30.24  ? 199 LYS A HB3  1 
ATOM   3093 H HG2  . LYS A 1 235 ? 19.530  -5.313  11.148  1.00 35.53  ? 199 LYS A HG2  1 
ATOM   3094 H HG3  . LYS A 1 235 ? 19.484  -3.871  10.481  1.00 35.53  ? 199 LYS A HG3  1 
ATOM   3095 H HD2  . LYS A 1 235 ? 18.765  -4.782  8.485   1.00 30.53  ? 199 LYS A HD2  1 
ATOM   3096 H HD3  . LYS A 1 235 ? 18.905  -6.250  9.078   1.00 30.53  ? 199 LYS A HD3  1 
ATOM   3097 H HE2  . LYS A 1 235 ? 17.051  -6.068  10.284  1.00 34.75  ? 199 LYS A HE2  1 
ATOM   3098 H HE3  . LYS A 1 235 ? 17.160  -4.485  10.376  1.00 34.75  ? 199 LYS A HE3  1 
ATOM   3099 H HZ1  . LYS A 1 235 ? 15.492  -5.031  8.980   1.00 28.65  ? 199 LYS A HZ1  1 
ATOM   3100 H HZ2  . LYS A 1 235 ? 16.531  -4.413  8.182   1.00 28.65  ? 199 LYS A HZ2  1 
ATOM   3101 H HZ3  . LYS A 1 235 ? 16.359  -5.851  8.159   1.00 28.65  ? 199 LYS A HZ3  1 
ATOM   3102 N N    . ARG A 1 236 ? 22.300  -2.052  9.824   1.00 23.29  ? 200 ARG A N    1 
ATOM   3103 C CA   . ARG A 1 236 ? 22.201  -0.663  10.251  1.00 27.01  ? 200 ARG A CA   1 
ATOM   3104 C C    . ARG A 1 236 ? 22.335  0.287   9.070   1.00 26.64  ? 200 ARG A C    1 
ATOM   3105 O O    . ARG A 1 236 ? 21.580  1.255   8.944   1.00 27.22  ? 200 ARG A O    1 
ATOM   3106 C CB   . ARG A 1 236 ? 23.263  -0.344  11.313  1.00 33.91  ? 200 ARG A CB   1 
ATOM   3107 C CG   . ARG A 1 236 ? 23.351  1.153   11.654  1.00 37.33  ? 200 ARG A CG   1 
ATOM   3108 C CD   . ARG A 1 236 ? 24.347  1.446   12.768  1.00 55.19  ? 200 ARG A CD   1 
ATOM   3109 N NE   . ARG A 1 236 ? 25.721  1.140   12.388  1.00 54.11  ? 200 ARG A NE   1 
ATOM   3110 C CZ   . ARG A 1 236 ? 26.435  1.826   11.502  1.00 45.78  ? 200 ARG A CZ   1 
ATOM   3111 N NH1  . ARG A 1 236 ? 25.928  2.867   10.861  1.00 41.12  ? 200 ARG A NH1  1 
ATOM   3112 N NH2  . ARG A 1 236 ? 27.686  1.448   11.243  1.00 34.60  ? 200 ARG A NH2  1 
ATOM   3113 H H    . ARG A 1 236 ? 23.023  -2.455  10.057  1.00 27.94  ? 200 ARG A H    1 
ATOM   3114 H HA   . ARG A 1 236 ? 21.328  -0.533  10.654  1.00 32.41  ? 200 ARG A HA   1 
ATOM   3115 H HB2  . ARG A 1 236 ? 23.046  -0.824  12.128  1.00 40.68  ? 200 ARG A HB2  1 
ATOM   3116 H HB3  . ARG A 1 236 ? 24.131  -0.626  10.983  1.00 40.68  ? 200 ARG A HB3  1 
ATOM   3117 H HG2  . ARG A 1 236 ? 23.632  1.641   10.865  1.00 44.79  ? 200 ARG A HG2  1 
ATOM   3118 H HG3  . ARG A 1 236 ? 22.478  1.463   11.943  1.00 44.79  ? 200 ARG A HG3  1 
ATOM   3119 H HD2  . ARG A 1 236 ? 24.300  2.388   12.994  1.00 66.21  ? 200 ARG A HD2  1 
ATOM   3120 H HD3  . ARG A 1 236 ? 24.123  0.908   13.543  1.00 66.21  ? 200 ARG A HD3  1 
ATOM   3121 H HE   . ARG A 1 236 ? 26.098  0.465   12.765  1.00 64.92  ? 200 ARG A HE   1 
ATOM   3122 H HH11 . ARG A 1 236 ? 25.119  3.114   11.013  1.00 49.33  ? 200 ARG A HH11 1 
ATOM   3123 H HH12 . ARG A 1 236 ? 26.409  3.297   10.291  1.00 49.33  ? 200 ARG A HH12 1 
ATOM   3124 H HH21 . ARG A 1 236 ? 28.023  0.768   11.648  1.00 41.50  ? 200 ARG A HH21 1 
ATOM   3125 H HH22 . ARG A 1 236 ? 28.158  1.885   10.671  1.00 41.50  ? 200 ARG A HH22 1 
ATOM   3126 N N    . LYS A 1 237 ? 23.306  0.038   8.201   1.00 21.84  ? 201 LYS A N    1 
ATOM   3127 C CA   . LYS A 1 237 ? 23.612  0.946   7.113   1.00 19.39  ? 201 LYS A CA   1 
ATOM   3128 C C    . LYS A 1 237 ? 22.511  1.002   6.071   1.00 20.81  ? 201 LYS A C    1 
ATOM   3129 O O    . LYS A 1 237 ? 22.413  2.002   5.362   1.00 23.95  ? 201 LYS A O    1 
ATOM   3130 C CB   . LYS A 1 237 ? 24.930  0.518   6.463   1.00 20.84  ? 201 LYS A CB   1 
ATOM   3131 C CG   . LYS A 1 237 ? 26.121  0.767   7.332   1.00 23.92  ? 201 LYS A CG   1 
ATOM   3132 C CD   . LYS A 1 237 ? 27.337  0.039   6.810   1.00 17.87  ? 201 LYS A CD   1 
ATOM   3133 C CE   . LYS A 1 237 ? 28.601  0.563   7.445   1.00 24.18  ? 201 LYS A CE   1 
ATOM   3134 N NZ   . LYS A 1 237 ? 29.753  -0.266  7.020   1.00 26.96  ? 201 LYS A NZ   1 
ATOM   3135 H H    . LYS A 1 237 ? 23.807  -0.660  8.222   1.00 26.19  ? 201 LYS A H    1 
ATOM   3136 H HA   . LYS A 1 237 ? 23.716  1.844   7.466   1.00 23.25  ? 201 LYS A HA   1 
ATOM   3137 H HB2  . LYS A 1 237 ? 24.893  -0.432  6.274   1.00 24.99  ? 201 LYS A HB2  1 
ATOM   3138 H HB3  . LYS A 1 237 ? 25.052  1.016   5.640   1.00 24.99  ? 201 LYS A HB3  1 
ATOM   3139 H HG2  . LYS A 1 237 ? 26.315  1.718   7.347   1.00 28.69  ? 201 LYS A HG2  1 
ATOM   3140 H HG3  . LYS A 1 237 ? 25.937  0.452   8.230   1.00 28.69  ? 201 LYS A HG3  1 
ATOM   3141 H HD2  . LYS A 1 237 ? 27.260  -0.906  7.015   1.00 21.43  ? 201 LYS A HD2  1 
ATOM   3142 H HD3  . LYS A 1 237 ? 27.401  0.166   5.850   1.00 21.43  ? 201 LYS A HD3  1 
ATOM   3143 H HE2  . LYS A 1 237 ? 28.755  1.479   7.165   1.00 29.00  ? 201 LYS A HE2  1 
ATOM   3144 H HE3  . LYS A 1 237 ? 28.525  0.520   8.411   1.00 29.00  ? 201 LYS A HE3  1 
ATOM   3145 H HZ1  . LYS A 1 237 ? 30.274  -0.444  7.720   1.00 32.34  ? 201 LYS A HZ1  1 
ATOM   3146 H HZ2  . LYS A 1 237 ? 29.465  -1.032  6.672   1.00 32.34  ? 201 LYS A HZ2  1 
ATOM   3147 H HZ3  . LYS A 1 237 ? 30.231  0.168   6.407   1.00 32.34  ? 201 LYS A HZ3  1 
ATOM   3148 N N    . MET A 1 238 ? 21.695  -0.055  5.956   1.00 19.46  ? 202 MET A N    1 
ATOM   3149 C CA   . MET A 1 238 ? 20.597  -0.039  4.995   1.00 18.34  ? 202 MET A CA   1 
ATOM   3150 C C    . MET A 1 238 ? 19.468  0.873   5.438   1.00 21.18  ? 202 MET A C    1 
ATOM   3151 O O    . MET A 1 238 ? 18.677  1.327   4.596   1.00 22.22  ? 202 MET A O    1 
ATOM   3152 C CB   . MET A 1 238 ? 20.041  -1.434  4.800   1.00 20.62  ? 202 MET A CB   1 
ATOM   3153 C CG   . MET A 1 238 ? 20.796  -2.252  3.786   1.00 19.13  ? 202 MET A CG   1 
ATOM   3154 S SD   . MET A 1 238 ? 20.015  -3.780  3.377   1.00 18.35  ? 202 MET A SD   1 
ATOM   3155 C CE   . MET A 1 238 ? 19.484  -4.465  4.931   1.00 19.94  ? 202 MET A CE   1 
ATOM   3156 H H    . MET A 1 238 ? 21.759  -0.779  6.417   1.00 23.34  ? 202 MET A H    1 
ATOM   3157 H HA   . MET A 1 238 ? 20.951  0.268   4.145   1.00 22.00  ? 202 MET A HA   1 
ATOM   3158 H HB2  . MET A 1 238 ? 20.078  -1.905  5.647   1.00 24.74  ? 202 MET A HB2  1 
ATOM   3159 H HB3  . MET A 1 238 ? 19.122  -1.364  4.499   1.00 24.74  ? 202 MET A HB3  1 
ATOM   3160 H HG2  . MET A 1 238 ? 20.880  -1.735  2.970   1.00 22.94  ? 202 MET A HG2  1 
ATOM   3161 H HG3  . MET A 1 238 ? 21.675  -2.456  4.142   1.00 22.94  ? 202 MET A HG3  1 
ATOM   3162 H HE1  . MET A 1 238 ? 19.034  -5.309  4.767   1.00 23.92  ? 202 MET A HE1  1 
ATOM   3163 H HE2  . MET A 1 238 ? 20.260  -4.608  5.495   1.00 23.92  ? 202 MET A HE2  1 
ATOM   3164 H HE3  . MET A 1 238 ? 18.874  -3.844  5.358   1.00 23.92  ? 202 MET A HE3  1 
ATOM   3165 N N    . GLY A 1 239 ? 19.404  1.175   6.727   1.00 23.86  ? 203 GLY A N    1 
ATOM   3166 C CA   . GLY A 1 239 ? 18.372  2.038   7.243   1.00 21.91  ? 203 GLY A CA   1 
ATOM   3167 C C    . GLY A 1 239 ? 17.105  1.255   7.434   1.00 22.37  ? 203 GLY A C    1 
ATOM   3168 O O    . GLY A 1 239 ? 17.048  0.032   7.297   1.00 21.10  ? 203 GLY A O    1 
ATOM   3169 H H    . GLY A 1 239 ? 19.954  0.887   7.322   1.00 28.63  ? 203 GLY A H    1 
ATOM   3170 H HA2  . GLY A 1 239 ? 18.646  2.411   8.096   1.00 26.28  ? 203 GLY A HA2  1 
ATOM   3171 H HA3  . GLY A 1 239 ? 18.205  2.764   6.621   1.00 26.28  ? 203 GLY A HA3  1 
ATOM   3172 N N    . PRO A 1 240 ? 16.051  1.952   7.799   1.00 19.28  ? 204 PRO A N    1 
ATOM   3173 C CA   . PRO A 1 240 ? 14.807  1.262   8.138   1.00 21.73  ? 204 PRO A CA   1 
ATOM   3174 C C    . PRO A 1 240 ? 14.186  0.548   6.959   1.00 21.80  ? 204 PRO A C    1 
ATOM   3175 O O    . PRO A 1 240 ? 14.340  0.918   5.793   1.00 19.90  ? 204 PRO A O    1 
ATOM   3176 C CB   . PRO A 1 240 ? 13.896  2.407   8.606   1.00 24.01  ? 204 PRO A CB   1 
ATOM   3177 C CG   . PRO A 1 240 ? 14.846  3.463   9.064   1.00 24.07  ? 204 PRO A CG   1 
ATOM   3178 C CD   . PRO A 1 240 ? 16.006  3.386   8.114   1.00 21.17  ? 204 PRO A CD   1 
ATOM   3179 H HA   . PRO A 1 240 ? 14.965  0.624   8.851   1.00 26.06  ? 204 PRO A HA   1 
ATOM   3180 H HB2  . PRO A 1 240 ? 13.350  2.722   7.869   1.00 28.81  ? 204 PRO A HB2  1 
ATOM   3181 H HB3  . PRO A 1 240 ? 13.329  2.106   9.334   1.00 28.81  ? 204 PRO A HB3  1 
ATOM   3182 H HG2  . PRO A 1 240 ? 14.419  4.332   9.019   1.00 28.88  ? 204 PRO A HG2  1 
ATOM   3183 H HG3  . PRO A 1 240 ? 15.131  3.279   9.973   1.00 28.88  ? 204 PRO A HG3  1 
ATOM   3184 H HD2  . PRO A 1 240 ? 15.840  3.914   7.317   1.00 25.39  ? 204 PRO A HD2  1 
ATOM   3185 H HD3  . PRO A 1 240 ? 16.827  3.677   8.540   1.00 25.39  ? 204 PRO A HD3  1 
ATOM   3186 N N    . ASP A 1 241 ? 13.392  -0.471  7.301   1.00 24.74  ? 205 ASP A N    1 
ATOM   3187 C CA   . ASP A 1 241 ? 12.438  -1.047  6.380   1.00 19.64  ? 205 ASP A CA   1 
ATOM   3188 C C    . ASP A 1 241 ? 13.094  -1.809  5.248   1.00 17.88  ? 205 ASP A C    1 
ATOM   3189 O O    . ASP A 1 241 ? 12.490  -1.989  4.188   1.00 21.55  ? 205 ASP A O    1 
ATOM   3190 C CB   . ASP A 1 241 ? 11.507  0.020   5.813   1.00 26.43  ? 205 ASP A CB   1 
ATOM   3191 C CG   . ASP A 1 241 ? 10.740  0.722   6.903   1.00 31.62  ? 205 ASP A CG   1 
ATOM   3192 O OD1  . ASP A 1 241 ? 10.422  0.041   7.897   1.00 29.25  ? 205 ASP A OD1  1 
ATOM   3193 O OD2  . ASP A 1 241 ? 10.490  1.944   6.789   1.00 31.10  ? 205 ASP A OD2  1 
ATOM   3194 H H    . ASP A 1 241 ? 13.396  -0.844  8.076   1.00 29.68  ? 205 ASP A H    1 
ATOM   3195 H HA   . ASP A 1 241 ? 11.907  -1.688  6.878   1.00 23.56  ? 205 ASP A HA   1 
ATOM   3196 H HB2  . ASP A 1 241 ? 12.031  0.681   5.334   1.00 31.71  ? 205 ASP A HB2  1 
ATOM   3197 H HB3  . ASP A 1 241 ? 10.869  -0.397  5.212   1.00 31.71  ? 205 ASP A HB3  1 
ATOM   3198 N N    . LYS A 1 242 ? 14.294  -2.335  5.498   1.00 19.91  ? 206 LYS A N    1 
ATOM   3199 C CA   . LYS A 1 242 ? 15.027  -3.100  4.497   1.00 20.55  ? 206 LYS A CA   1 
ATOM   3200 C C    . LYS A 1 242 ? 15.201  -4.516  5.011   1.00 18.05  ? 206 LYS A C    1 
ATOM   3201 O O    . LYS A 1 242 ? 15.510  -4.717  6.189   1.00 18.01  ? 206 LYS A O    1 
ATOM   3202 C CB   . LYS A 1 242 ? 16.384  -2.471  4.197   1.00 19.36  ? 206 LYS A CB   1 
ATOM   3203 C CG   . LYS A 1 242 ? 16.266  -1.141  3.462   1.00 21.44  ? 206 LYS A CG   1 
ATOM   3204 C CD   . LYS A 1 242 ? 15.542  -1.280  2.146   1.00 22.00  ? 206 LYS A CD   1 
ATOM   3205 C CE   . LYS A 1 242 ? 15.742  -0.075  1.212   1.00 30.38  ? 206 LYS A CE   1 
ATOM   3206 N NZ   . LYS A 1 242 ? 15.657  1.214   1.922   1.00 37.10  ? 206 LYS A NZ   1 
ATOM   3207 H H    . LYS A 1 242 ? 14.706  -2.259  6.250   1.00 23.88  ? 206 LYS A H    1 
ATOM   3208 H HA   . LYS A 1 242 ? 14.532  -3.126  3.664   1.00 24.65  ? 206 LYS A HA   1 
ATOM   3209 H HB2  . LYS A 1 242 ? 16.850  -2.313  5.032   1.00 23.22  ? 206 LYS A HB2  1 
ATOM   3210 H HB3  . LYS A 1 242 ? 16.897  -3.078  3.640   1.00 23.22  ? 206 LYS A HB3  1 
ATOM   3211 H HG2  . LYS A 1 242 ? 15.772  -0.515  4.014   1.00 25.71  ? 206 LYS A HG2  1 
ATOM   3212 H HG3  . LYS A 1 242 ? 17.155  -0.797  3.283   1.00 25.71  ? 206 LYS A HG3  1 
ATOM   3213 H HD2  . LYS A 1 242 ? 15.871  -2.069  1.687   1.00 26.39  ? 206 LYS A HD2  1 
ATOM   3214 H HD3  . LYS A 1 242 ? 14.591  -1.368  2.317   1.00 26.39  ? 206 LYS A HD3  1 
ATOM   3215 H HE2  . LYS A 1 242 ? 16.619  -0.134  0.803   1.00 36.45  ? 206 LYS A HE2  1 
ATOM   3216 H HE3  . LYS A 1 242 ? 15.055  -0.087  0.528   1.00 36.45  ? 206 LYS A HE3  1 
ATOM   3217 H HZ1  . LYS A 1 242 ? 15.613  1.882   1.336   1.00 44.51  ? 206 LYS A HZ1  1 
ATOM   3218 H HZ2  . LYS A 1 242 ? 14.929  1.231   2.435   1.00 44.51  ? 206 LYS A HZ2  1 
ATOM   3219 H HZ3  . LYS A 1 242 ? 16.375  1.326   2.436   1.00 44.51  ? 206 LYS A HZ3  1 
ATOM   3220 N N    . ILE A 1 243 ? 14.971  -5.476  4.125   1.00 15.86  ? 207 ILE A N    1 
ATOM   3221 C CA   . ILE A 1 243 ? 15.031  -6.894  4.448   1.00 12.40  ? 207 ILE A CA   1 
ATOM   3222 C C    . ILE A 1 243 ? 16.453  -7.404  4.305   1.00 15.09  ? 207 ILE A C    1 
ATOM   3223 O O    . ILE A 1 243 ? 17.083  -7.220  3.261   1.00 15.22  ? 207 ILE A O    1 
ATOM   3224 C CB   . ILE A 1 243 ? 14.087  -7.701  3.547   1.00 15.21  ? 207 ILE A CB   1 
ATOM   3225 C CG1  . ILE A 1 243 ? 12.634  -7.366  3.800   1.00 18.17  ? 207 ILE A CG1  1 
ATOM   3226 C CG2  . ILE A 1 243 ? 14.326  -9.223  3.726   1.00 14.58  ? 207 ILE A CG2  1 
ATOM   3227 C CD1  . ILE A 1 243 ? 11.795  -7.693  2.605   1.00 17.89  ? 207 ILE A CD1  1 
ATOM   3228 H H    . ILE A 1 243 ? 14.771  -5.326  3.302   1.00 19.02  ? 207 ILE A H    1 
ATOM   3229 H HA   . ILE A 1 243 ? 14.765  -7.003  5.374   1.00 14.87  ? 207 ILE A HA   1 
ATOM   3230 H HB   . ILE A 1 243 ? 14.291  -7.452  2.632   1.00 18.24  ? 207 ILE A HB   1 
ATOM   3231 H HG12 . ILE A 1 243 ? 12.310  -7.882  4.554   1.00 21.79  ? 207 ILE A HG12 1 
ATOM   3232 H HG13 . ILE A 1 243 ? 12.549  -6.418  3.985   1.00 21.79  ? 207 ILE A HG13 1 
ATOM   3233 H HG21 . ILE A 1 243 ? 13.541  -9.704  3.420   1.00 17.49  ? 207 ILE A HG21 1 
ATOM   3234 H HG22 . ILE A 1 243 ? 15.099  -9.485  3.203   1.00 17.49  ? 207 ILE A HG22 1 
ATOM   3235 H HG23 . ILE A 1 243 ? 14.482  -9.410  4.665   1.00 17.49  ? 207 ILE A HG23 1 
ATOM   3236 H HD11 . ILE A 1 243 ? 10.889  -7.384  2.761   1.00 21.46  ? 207 ILE A HD11 1 
ATOM   3237 H HD12 . ILE A 1 243 ? 12.167  -7.249  1.827   1.00 21.46  ? 207 ILE A HD12 1 
ATOM   3238 H HD13 . ILE A 1 243 ? 11.798  -8.654  2.471   1.00 21.46  ? 207 ILE A HD13 1 
ATOM   3239 N N    . LEU A 1 244 ? 16.903  -8.140  5.301   1.00 13.32  ? 208 LEU A N    1 
ATOM   3240 C CA   . LEU A 1 244 ? 18.180  -8.846  5.263   1.00 11.79  ? 208 LEU A CA   1 
ATOM   3241 C C    . LEU A 1 244 ? 17.909  -10.344 5.282   1.00 13.18  ? 208 LEU A C    1 
ATOM   3242 O O    . LEU A 1 244 ? 17.490  -10.886 6.298   1.00 14.63  ? 208 LEU A O    1 
ATOM   3243 C CB   . LEU A 1 244 ? 19.056  -8.453  6.452   1.00 14.77  ? 208 LEU A CB   1 
ATOM   3244 C CG   . LEU A 1 244 ? 20.492  -8.929  6.450   1.00 19.28  ? 208 LEU A CG   1 
ATOM   3245 C CD1  . LEU A 1 244 ? 21.118  -8.720  5.067   1.00 23.91  ? 208 LEU A CD1  1 
ATOM   3246 C CD2  . LEU A 1 244 ? 21.268  -8.155  7.542   1.00 22.44  ? 208 LEU A CD2  1 
ATOM   3247 H H    . LEU A 1 244 ? 16.476  -8.254  6.039   1.00 15.98  ? 208 LEU A H    1 
ATOM   3248 H HA   . LEU A 1 244 ? 18.641  -8.620  4.440   1.00 14.14  ? 208 LEU A HA   1 
ATOM   3249 H HB2  . LEU A 1 244 ? 19.082  -7.484  6.493   1.00 17.72  ? 208 LEU A HB2  1 
ATOM   3250 H HB3  . LEU A 1 244 ? 18.643  -8.809  7.254   1.00 17.72  ? 208 LEU A HB3  1 
ATOM   3251 H HG   . LEU A 1 244 ? 20.539  -9.878  6.645   1.00 23.12  ? 208 LEU A HG   1 
ATOM   3252 H HD11 . LEU A 1 244 ? 22.084  -8.751  5.150   1.00 28.68  ? 208 LEU A HD11 1 
ATOM   3253 H HD12 . LEU A 1 244 ? 20.815  -9.424  4.473   1.00 28.68  ? 208 LEU A HD12 1 
ATOM   3254 H HD13 . LEU A 1 244 ? 20.843  -7.856  4.723   1.00 28.68  ? 208 LEU A HD13 1 
ATOM   3255 H HD21 . LEU A 1 244 ? 22.202  -8.415  7.509   1.00 26.92  ? 208 LEU A HD21 1 
ATOM   3256 H HD22 . LEU A 1 244 ? 21.184  -7.204  7.375   1.00 26.92  ? 208 LEU A HD22 1 
ATOM   3257 H HD23 . LEU A 1 244 ? 20.895  -8.374  8.410   1.00 26.92  ? 208 LEU A HD23 1 
ATOM   3258 N N    . LEU A 1 245 ? 18.181  -10.997 4.170   1.00 13.92  ? 209 LEU A N    1 
ATOM   3259 C CA   . LEU A 1 245 ? 18.055  -12.435 4.023   1.00 15.03  ? 209 LEU A CA   1 
ATOM   3260 C C    . LEU A 1 245 ? 19.455  -13.038 3.945   1.00 18.97  ? 209 LEU A C    1 
ATOM   3261 O O    . LEU A 1 245 ? 20.222  -12.679 3.041   1.00 16.56  ? 209 LEU A O    1 
ATOM   3262 C CB   . LEU A 1 245 ? 17.264  -12.750 2.772   1.00 11.46  ? 209 LEU A CB   1 
ATOM   3263 C CG   . LEU A 1 245 ? 17.083  -14.210 2.337   1.00 20.58  ? 209 LEU A CG   1 
ATOM   3264 C CD1  . LEU A 1 245 ? 16.943  -15.161 3.429   1.00 28.69  ? 209 LEU A CD1  1 
ATOM   3265 C CD2  . LEU A 1 245 ? 15.855  -14.293 1.415   1.00 21.38  ? 209 LEU A CD2  1 
ATOM   3266 H H    . LEU A 1 245 ? 18.453  -10.611 3.451   1.00 16.70  ? 209 LEU A H    1 
ATOM   3267 H HA   . LEU A 1 245 ? 17.603  -12.820 4.790   1.00 18.03  ? 209 LEU A HA   1 
ATOM   3268 H HB2  . LEU A 1 245 ? 16.371  -12.392 2.898   1.00 13.74  ? 209 LEU A HB2  1 
ATOM   3269 H HB3  . LEU A 1 245 ? 17.701  -12.299 2.033   1.00 13.74  ? 209 LEU A HB3  1 
ATOM   3270 H HG   . LEU A 1 245 ? 17.895  -14.475 1.878   1.00 24.68  ? 209 LEU A HG   1 
ATOM   3271 H HD11 . LEU A 1 245 ? 16.984  -16.062 3.070   1.00 34.42  ? 209 LEU A HD11 1 
ATOM   3272 H HD12 . LEU A 1 245 ? 17.665  -15.024 4.062   1.00 34.42  ? 209 LEU A HD12 1 
ATOM   3273 H HD13 . LEU A 1 245 ? 16.088  -15.018 3.865   1.00 34.42  ? 209 LEU A HD13 1 
ATOM   3274 H HD21 . LEU A 1 245 ? 15.697  -15.221 1.183   1.00 25.65  ? 209 LEU A HD21 1 
ATOM   3275 H HD22 . LEU A 1 245 ? 15.085  -13.932 1.882   1.00 25.65  ? 209 LEU A HD22 1 
ATOM   3276 H HD23 . LEU A 1 245 ? 16.028  -13.776 0.612   1.00 25.65  ? 209 LEU A HD23 1 
ATOM   3277 N N    . GLY A 1 246 ? 19.768  -13.939 4.856   1.00 13.63  ? 210 GLY A N    1 
ATOM   3278 C CA   . GLY A 1 246 ? 21.040  -14.637 4.844   1.00 17.74  ? 210 GLY A CA   1 
ATOM   3279 C C    . GLY A 1 246 ? 20.861  -16.050 4.314   1.00 18.42  ? 210 GLY A C    1 
ATOM   3280 O O    . GLY A 1 246 ? 19.980  -16.780 4.764   1.00 15.48  ? 210 GLY A O    1 
ATOM   3281 H H    . GLY A 1 246 ? 19.252  -14.168 5.504   1.00 16.35  ? 210 GLY A H    1 
ATOM   3282 H HA2  . GLY A 1 246 ? 21.670  -14.166 4.276   1.00 21.27  ? 210 GLY A HA2  1 
ATOM   3283 H HA3  . GLY A 1 246 ? 21.400  -14.683 5.744   1.00 21.27  ? 210 GLY A HA3  1 
ATOM   3284 N N    . ASN A 1 247 ? 21.724  -16.425 3.384   1.00 15.91  ? 211 ASN A N    1 
ATOM   3285 C CA   . ASN A 1 247 ? 21.612  -17.747 2.817   1.00 19.86  ? 211 ASN A CA   1 
ATOM   3286 C C    . ASN A 1 247 ? 22.153  -18.772 3.763   1.00 20.53  ? 211 ASN A C    1 
ATOM   3287 O O    . ASN A 1 247 ? 23.230  -18.610 4.282   1.00 21.26  ? 211 ASN A O    1 
ATOM   3288 C CB   . ASN A 1 247 ? 22.322  -17.869 1.485   1.00 19.44  ? 211 ASN A CB   1 
ATOM   3289 C CG   . ASN A 1 247 ? 21.947  -19.125 0.725   1.00 26.85  ? 211 ASN A CG   1 
ATOM   3290 O OD1  . ASN A 1 247 ? 20.959  -19.785 1.016   1.00 21.43  ? 211 ASN A OD1  1 
ATOM   3291 N ND2  . ASN A 1 247 ? 22.744  -19.446 -0.271  1.00 25.46  ? 211 ASN A ND2  1 
ATOM   3292 H H    . ASN A 1 247 ? 22.372  -15.955 3.061   1.00 19.08  ? 211 ASN A H    1 
ATOM   3293 H HA   . ASN A 1 247 ? 20.664  -17.944 2.667   1.00 23.82  ? 211 ASN A HA   1 
ATOM   3294 H HB2  . ASN A 1 247 ? 22.086  -17.106 0.935   1.00 23.32  ? 211 ASN A HB2  1 
ATOM   3295 H HB3  . ASN A 1 247 ? 23.278  -17.878 1.634   1.00 23.32  ? 211 ASN A HB3  1 
ATOM   3296 H HD21 . ASN A 1 247 ? 22.707  -20.346 -0.652  1.00 30.54  ? 211 ASN A HD21 1 
ATOM   3297 H HD22 . ASN A 1 247 ? 23.375  -18.783 -0.621  1.00 30.54  ? 211 ASN A HD22 1 
ATOM   3298 N N    . ASN A 1 248 ? 21.368  -19.822 3.978   1.00 21.29  ? 212 ASN A N    1 
ATOM   3299 C CA   . ASN A 1 248 ? 21.756  -20.921 4.843   1.00 25.31  ? 212 ASN A CA   1 
ATOM   3300 C C    . ASN A 1 248 ? 22.064  -20.415 6.242   1.00 23.56  ? 212 ASN A C    1 
ATOM   3301 O O    . ASN A 1 248 ? 22.971  -20.916 6.922   1.00 23.30  ? 212 ASN A O    1 
ATOM   3302 C CB   . ASN A 1 248 ? 22.932  -21.679 4.230   1.00 21.73  ? 212 ASN A CB   1 
ATOM   3303 C CG   . ASN A 1 248 ? 22.570  -22.278 2.898   1.00 25.18  ? 212 ASN A CG   1 
ATOM   3304 O OD1  . ASN A 1 248 ? 21.606  -23.048 2.783   1.00 23.97  ? 212 ASN A OD1  1 
ATOM   3305 N ND2  . ASN A 1 248 ? 23.307  -21.921 1.880   1.00 23.17  ? 212 ASN A ND2  1 
ATOM   3306 H H    . ASN A 1 248 ? 20.590  -19.926 3.626   1.00 25.53  ? 212 ASN A H    1 
ATOM   3307 H HA   . ASN A 1 248 ? 21.022  -21.549 4.933   1.00 30.36  ? 212 ASN A HA   1 
ATOM   3308 H HB2  . ASN A 1 248 ? 23.674  -21.068 4.099   1.00 26.06  ? 212 ASN A HB2  1 
ATOM   3309 H HB3  . ASN A 1 248 ? 23.195  -22.398 4.826   1.00 26.06  ? 212 ASN A HB3  1 
ATOM   3310 H HD21 . ASN A 1 248 ? 23.141  -22.236 1.097   1.00 27.79  ? 212 ASN A HD21 1 
ATOM   3311 H HD22 . ASN A 1 248 ? 23.959  -21.372 1.992   1.00 27.79  ? 212 ASN A HD22 1 
ATOM   3312 N N    . ALA A 1 249 ? 21.294  -19.415 6.684   1.00 19.39  ? 213 ALA A N    1 
ATOM   3313 C CA   . ALA A 1 249 ? 21.593  -18.815 7.988   1.00 22.65  ? 213 ALA A CA   1 
ATOM   3314 C C    . ALA A 1 249 ? 20.977  -19.611 9.142   1.00 23.85  ? 213 ALA A C    1 
ATOM   3315 O O    . ALA A 1 249 ? 21.081  -19.195 10.299  1.00 26.08  ? 213 ALA A O    1 
ATOM   3316 C CB   . ALA A 1 249 ? 21.149  -17.348 8.030   1.00 24.22  ? 213 ALA A CB   1 
ATOM   3317 H H    . ALA A 1 249 ? 20.621  -19.082 6.265   1.00 23.26  ? 213 ALA A H    1 
ATOM   3318 H HA   . ALA A 1 249 ? 22.555  -18.805 8.116   1.00 27.17  ? 213 ALA A HA   1 
ATOM   3319 H HB1  . ALA A 1 249 ? 21.279  -17.004 8.927   1.00 29.05  ? 213 ALA A HB1  1 
ATOM   3320 H HB2  . ALA A 1 249 ? 21.682  -16.838 7.400   1.00 29.05  ? 213 ALA A HB2  1 
ATOM   3321 H HB3  . ALA A 1 249 ? 20.211  -17.295 7.788   1.00 29.05  ? 213 ALA A HB3  1 
ATOM   3322 N N    . ASN A 1 250 ? 20.389  -20.779 8.851   1.00 24.81  ? 214 ASN A N    1 
ATOM   3323 C CA   . ASN A 1 250 ? 19.997  -21.722 9.883   1.00 26.92  ? 214 ASN A CA   1 
ATOM   3324 C C    . ASN A 1 250 ? 21.184  -22.472 10.458  1.00 29.61  ? 214 ASN A C    1 
ATOM   3325 O O    . ASN A 1 250 ? 21.060  -23.058 11.538  1.00 27.12  ? 214 ASN A O    1 
ATOM   3326 C CB   . ASN A 1 250 ? 19.030  -22.761 9.308   1.00 20.78  ? 214 ASN A CB   1 
ATOM   3327 C CG   . ASN A 1 250 ? 19.611  -23.482 8.095   1.00 24.16  ? 214 ASN A CG   1 
ATOM   3328 O OD1  . ASN A 1 250 ? 19.731  -22.912 7.020   1.00 21.75  ? 214 ASN A OD1  1 
ATOM   3329 N ND2  . ASN A 1 250 ? 19.959  -24.750 8.265   1.00 27.11  ? 214 ASN A ND2  1 
ATOM   3330 H H    . ASN A 1 250 ? 20.208  -21.044 8.053   1.00 29.76  ? 214 ASN A H    1 
ATOM   3331 H HA   . ASN A 1 250 ? 19.552  -21.228 10.590  1.00 32.29  ? 214 ASN A HA   1 
ATOM   3332 H HB2  . ASN A 1 250 ? 18.833  -23.423 9.988   1.00 24.93  ? 214 ASN A HB2  1 
ATOM   3333 H HB3  . ASN A 1 250 ? 18.213  -22.316 9.032   1.00 24.93  ? 214 ASN A HB3  1 
ATOM   3334 H HD21 . ASN A 1 250 ? 20.291  -25.196 7.608   1.00 32.52  ? 214 ASN A HD21 1 
ATOM   3335 H HD22 . ASN A 1 250 ? 19.854  -25.126 9.031   1.00 32.52  ? 214 ASN A HD22 1 
ATOM   3336 N N    . GLN A 1 251 ? 22.306  -22.497 9.741   1.00 28.02  ? 215 GLN A N    1 
ATOM   3337 C CA   . GLN A 1 251 ? 23.433  -23.325 10.140  1.00 30.76  ? 215 GLN A CA   1 
ATOM   3338 C C    . GLN A 1 251 ? 24.105  -22.751 11.377  1.00 26.08  ? 215 GLN A C    1 
ATOM   3339 O O    . GLN A 1 251 ? 24.117  -21.540 11.607  1.00 27.66  ? 215 GLN A O    1 
ATOM   3340 C CB   . GLN A 1 251 ? 24.410  -23.456 8.975   1.00 33.23  ? 215 GLN A CB   1 
ATOM   3341 C CG   . GLN A 1 251 ? 23.743  -24.149 7.771   1.00 30.73  ? 215 GLN A CG   1 
ATOM   3342 C CD   . GLN A 1 251 ? 24.714  -24.476 6.665   1.00 39.84  ? 215 GLN A CD   1 
ATOM   3343 O OE1  . GLN A 1 251 ? 25.788  -23.873 6.560   1.00 34.38  ? 215 GLN A OE1  1 
ATOM   3344 N NE2  . GLN A 1 251 ? 24.355  -25.459 5.838   1.00 36.99  ? 215 GLN A NE2  1 
ATOM   3345 H H    . GLN A 1 251 ? 22.437  -22.045 9.021   1.00 33.62  ? 215 GLN A H    1 
ATOM   3346 H HA   . GLN A 1 251 ? 23.137  -24.219 10.373  1.00 36.91  ? 215 GLN A HA   1 
ATOM   3347 H HB2  . GLN A 1 251 ? 24.702  -22.573 8.699   1.00 39.87  ? 215 GLN A HB2  1 
ATOM   3348 H HB3  . GLN A 1 251 ? 25.173  -23.987 9.252   1.00 39.87  ? 215 GLN A HB3  1 
ATOM   3349 H HG2  . GLN A 1 251 ? 23.339  -24.979 8.069   1.00 36.87  ? 215 GLN A HG2  1 
ATOM   3350 H HG3  . GLN A 1 251 ? 23.063  -23.561 7.406   1.00 36.87  ? 215 GLN A HG3  1 
ATOM   3351 H HE21 . GLN A 1 251 ? 23.605  -25.865 5.953   1.00 44.37  ? 215 GLN A HE21 1 
ATOM   3352 H HE22 . GLN A 1 251 ? 24.872  -25.687 5.190   1.00 44.37  ? 215 GLN A HE22 1 
ATOM   3353 N N    . ASP A 1 252 ? 24.663  -23.640 12.190  1.00 32.35  ? 216 ASP A N    1 
ATOM   3354 C CA   . ASP A 1 252 ? 25.334  -23.184 13.401  1.00 32.55  ? 216 ASP A CA   1 
ATOM   3355 C C    . ASP A 1 252 ? 26.387  -22.130 13.076  1.00 30.36  ? 216 ASP A C    1 
ATOM   3356 O O    . ASP A 1 252 ? 26.584  -21.182 13.845  1.00 34.12  ? 216 ASP A O    1 
ATOM   3357 H H    . ASP A 1 252 ? 24.669  -24.491 12.067  1.00 38.81  ? 216 ASP A H    1 
ATOM   3358 N N    . ILE A 1 253 ? 27.062  -22.269 11.928  1.00 29.95  ? 217 ILE A N    1 
ATOM   3359 C CA   . ILE A 1 253 ? 28.141  -21.344 11.570  1.00 28.70  ? 217 ILE A CA   1 
ATOM   3360 C C    . ILE A 1 253 ? 27.629  -19.914 11.432  1.00 30.21  ? 217 ILE A C    1 
ATOM   3361 O O    . ILE A 1 253 ? 28.421  -18.964 11.467  1.00 28.18  ? 217 ILE A O    1 
ATOM   3362 H H    . ILE A 1 253 ? 26.916  -22.885 11.346  1.00 35.93  ? 217 ILE A H    1 
ATOM   3363 N N    . ALA A 1 254 ? 26.317  -19.732 11.290  1.00 27.16  ? 218 ALA A N    1 
ATOM   3364 C CA   . ALA A 1 254 ? 25.725  -18.404 11.126  1.00 30.62  ? 218 ALA A CA   1 
ATOM   3365 C C    . ALA A 1 254 ? 25.062  -17.867 12.393  1.00 30.31  ? 218 ALA A C    1 
ATOM   3366 O O    . ALA A 1 254 ? 24.396  -16.828 12.335  1.00 28.35  ? 218 ALA A O    1 
ATOM   3367 C CB   . ALA A 1 254 ? 24.696  -18.431 9.991   1.00 34.57  ? 218 ALA A CB   1 
ATOM   3368 H H    . ALA A 1 254 ? 25.741  -20.371 11.286  1.00 32.58  ? 218 ALA A H    1 
ATOM   3369 H HA   . ALA A 1 254 ? 26.438  -17.791 10.892  1.00 36.74  ? 218 ALA A HA   1 
ATOM   3370 H HB1  . ALA A 1 254 ? 24.315  -17.545 9.889   1.00 41.47  ? 218 ALA A HB1  1 
ATOM   3371 H HB2  . ALA A 1 254 ? 25.139  -18.698 9.170   1.00 41.47  ? 218 ALA A HB2  1 
ATOM   3372 H HB3  . ALA A 1 254 ? 23.998  -19.067 10.213  1.00 41.47  ? 218 ALA A HB3  1 
ATOM   3373 N N    . LYS A 1 255 ? 25.224  -18.545 13.534  1.00 32.08  ? 219 LYS A N    1 
ATOM   3374 C CA   . LYS A 1 255 ? 24.485  -18.170 14.738  1.00 33.10  ? 219 LYS A CA   1 
ATOM   3375 C C    . LYS A 1 255 ? 24.716  -16.716 15.133  1.00 31.75  ? 219 LYS A C    1 
ATOM   3376 O O    . LYS A 1 255 ? 23.811  -16.067 15.669  1.00 27.48  ? 219 LYS A O    1 
ATOM   3377 C CB   . LYS A 1 255 ? 24.866  -19.104 15.893  1.00 34.39  ? 219 LYS A CB   1 
ATOM   3378 C CG   . LYS A 1 255 ? 26.365  -19.221 16.131  1.00 45.36  ? 219 LYS A CG   1 
ATOM   3379 C CD   . LYS A 1 255 ? 26.729  -19.175 17.610  1.00 58.82  ? 219 LYS A CD   1 
ATOM   3380 C CE   . LYS A 1 255 ? 28.125  -19.760 17.849  1.00 57.64  ? 219 LYS A CE   1 
ATOM   3381 N NZ   . LYS A 1 255 ? 29.239  -18.873 17.344  1.00 55.95  ? 219 LYS A NZ   1 
ATOM   3382 H H    . LYS A 1 255 ? 25.750  -19.218 13.634  1.00 38.48  ? 219 LYS A H    1 
ATOM   3383 H HA   . LYS A 1 255 ? 23.537  -18.273 14.559  1.00 39.71  ? 219 LYS A HA   1 
ATOM   3384 H HB2  . LYS A 1 255 ? 24.463  -18.769 16.709  1.00 41.26  ? 219 LYS A HB2  1 
ATOM   3385 H HB3  . LYS A 1 255 ? 24.529  -19.993 15.697  1.00 41.26  ? 219 LYS A HB3  1 
ATOM   3386 H HG2  . LYS A 1 255 ? 26.679  -20.065 15.771  1.00 54.42  ? 219 LYS A HG2  1 
ATOM   3387 H HG3  . LYS A 1 255 ? 26.815  -18.484 15.689  1.00 54.42  ? 219 LYS A HG3  1 
ATOM   3388 H HD2  . LYS A 1 255 ? 26.726  -18.254 17.916  1.00 70.58  ? 219 LYS A HD2  1 
ATOM   3389 H HD3  . LYS A 1 255 ? 26.087  -19.695 18.118  1.00 70.58  ? 219 LYS A HD3  1 
ATOM   3390 H HE2  . LYS A 1 255 ? 28.254  -19.886 18.802  1.00 69.16  ? 219 LYS A HE2  1 
ATOM   3391 H HE3  . LYS A 1 255 ? 28.192  -20.612 17.390  1.00 69.16  ? 219 LYS A HE3  1 
ATOM   3392 H HZ1  . LYS A 1 255 ? 29.162  -18.759 16.465  1.00 67.13  ? 219 LYS A HZ1  1 
ATOM   3393 H HZ2  . LYS A 1 255 ? 29.199  -18.078 17.743  1.00 67.13  ? 219 LYS A HZ2  1 
ATOM   3394 H HZ3  . LYS A 1 255 ? 30.028  -19.245 17.519  1.00 67.13  ? 219 LYS A HZ3  1 
ATOM   3395 N N    . ASP A 1 256 ? 25.906  -16.173 14.888  1.00 27.58  ? 220 ASP A N    1 
ATOM   3396 C CA   . ASP A 1 256 ? 26.115  -14.783 15.274  1.00 25.36  ? 220 ASP A CA   1 
ATOM   3397 C C    . ASP A 1 256 ? 25.487  -13.811 14.289  1.00 29.40  ? 220 ASP A C    1 
ATOM   3398 O O    . ASP A 1 256 ? 25.218  -12.660 14.658  1.00 27.53  ? 220 ASP A O    1 
ATOM   3399 C CB   . ASP A 1 256 ? 27.618  -14.494 15.415  1.00 29.16  ? 220 ASP A CB   1 
ATOM   3400 C CG   . ASP A 1 256 ? 28.289  -15.401 16.430  1.00 37.94  ? 220 ASP A CG   1 
ATOM   3401 O OD1  . ASP A 1 256 ? 27.872  -15.349 17.600  1.00 37.67  ? 220 ASP A OD1  1 
ATOM   3402 O OD2  . ASP A 1 256 ? 29.202  -16.182 16.051  1.00 39.25  ? 220 ASP A OD2  1 
ATOM   3403 H H    . ASP A 1 256 ? 26.574  -16.569 14.518  1.00 33.09  ? 220 ASP A H    1 
ATOM   3404 H HA   . ASP A 1 256 ? 25.708  -14.631 16.141  1.00 30.42  ? 220 ASP A HA   1 
ATOM   3405 H HB2  . ASP A 1 256 ? 28.049  -14.632 14.557  1.00 34.98  ? 220 ASP A HB2  1 
ATOM   3406 H HB3  . ASP A 1 256 ? 27.739  -13.576 15.704  1.00 34.98  ? 220 ASP A HB3  1 
ATOM   3407 N N    . ALA A 1 257 ? 25.264  -14.252 13.050  1.00 26.06  ? 221 ALA A N    1 
ATOM   3408 C CA   . ALA A 1 257 ? 24.611  -13.438 12.034  1.00 26.75  ? 221 ALA A CA   1 
ATOM   3409 C C    . ALA A 1 257 ? 23.094  -13.497 12.145  1.00 28.02  ? 221 ALA A C    1 
ATOM   3410 O O    . ALA A 1 257 ? 22.411  -12.509 11.883  1.00 29.44  ? 221 ALA A O    1 
ATOM   3411 C CB   . ALA A 1 257 ? 25.031  -13.931 10.648  1.00 25.69  ? 221 ALA A CB   1 
ATOM   3412 H H    . ALA A 1 257 ? 25.486  -15.034 12.769  1.00 31.26  ? 221 ALA A H    1 
ATOM   3413 H HA   . ALA A 1 257 ? 24.888  -12.516 12.151  1.00 32.09  ? 221 ALA A HA   1 
ATOM   3414 H HB1  . ALA A 1 257 ? 24.615  -13.370 9.974   1.00 30.82  ? 221 ALA A HB1  1 
ATOM   3415 H HB2  . ALA A 1 257 ? 25.997  -13.877 10.573  1.00 30.82  ? 221 ALA A HB2  1 
ATOM   3416 H HB3  . ALA A 1 257 ? 24.741  -14.850 10.538  1.00 30.82  ? 221 ALA A HB3  1 
ATOM   3417 N N    . PHE A 1 258 ? 22.573  -14.658 12.515  1.00 24.61  ? 222 PHE A N    1 
ATOM   3418 C CA   . PHE A 1 258 ? 21.136  -14.908 12.484  1.00 31.90  ? 222 PHE A CA   1 
ATOM   3419 C C    . PHE A 1 258 ? 20.322  -13.843 13.187  1.00 30.64  ? 222 PHE A C    1 
ATOM   3420 O O    . PHE A 1 258 ? 19.280  -13.443 12.639  1.00 28.84  ? 222 PHE A O    1 
ATOM   3421 C CB   . PHE A 1 258 ? 20.912  -16.293 13.106  1.00 36.37  ? 222 PHE A CB   1 
ATOM   3422 C CG   . PHE A 1 258 ? 19.479  -16.713 13.180  1.00 41.85  ? 222 PHE A CG   1 
ATOM   3423 C CD1  . PHE A 1 258 ? 18.884  -17.363 12.118  1.00 40.66  ? 222 PHE A CD1  1 
ATOM   3424 C CD2  . PHE A 1 258 ? 18.738  -16.480 14.328  1.00 41.93  ? 222 PHE A CD2  1 
ATOM   3425 C CE1  . PHE A 1 258 ? 17.573  -17.772 12.191  1.00 38.57  ? 222 PHE A CE1  1 
ATOM   3426 C CE2  . PHE A 1 258 ? 17.422  -16.879 14.407  1.00 44.82  ? 222 PHE A CE2  1 
ATOM   3427 C CZ   . PHE A 1 258 ? 16.839  -17.523 13.333  1.00 39.54  ? 222 PHE A CZ   1 
ATOM   3428 H H    . PHE A 1 258 ? 23.034  -15.329 12.792  1.00 29.52  ? 222 PHE A H    1 
ATOM   3429 H HA   . PHE A 1 258 ? 20.823  -14.912 11.566  1.00 38.27  ? 222 PHE A HA   1 
ATOM   3430 H HB2  . PHE A 1 258 ? 21.383  -16.951 12.572  1.00 43.63  ? 222 PHE A HB2  1 
ATOM   3431 H HB3  . PHE A 1 258 ? 21.263  -16.286 14.010  1.00 43.63  ? 222 PHE A HB3  1 
ATOM   3432 H HD1  . PHE A 1 258 ? 19.375  -17.526 11.345  1.00 48.79  ? 222 PHE A HD1  1 
ATOM   3433 H HD2  . PHE A 1 258 ? 19.134  -16.051 15.053  1.00 50.30  ? 222 PHE A HD2  1 
ATOM   3434 H HE1  . PHE A 1 258 ? 17.181  -18.215 11.473  1.00 46.27  ? 222 PHE A HE1  1 
ATOM   3435 H HE2  . PHE A 1 258 ? 16.929  -16.714 15.178  1.00 53.77  ? 222 PHE A HE2  1 
ATOM   3436 H HZ   . PHE A 1 258 ? 15.950  -17.791 13.380  1.00 47.44  ? 222 PHE A HZ   1 
ATOM   3437 N N    . PRO A 1 259 ? 20.699  -13.369 14.377  1.00 24.08  ? 223 PRO A N    1 
ATOM   3438 C CA   . PRO A 1 259 ? 19.838  -12.414 15.087  1.00 31.52  ? 223 PRO A CA   1 
ATOM   3439 C C    . PRO A 1 259 ? 19.489  -11.186 14.275  1.00 23.71  ? 223 PRO A C    1 
ATOM   3440 O O    . PRO A 1 259 ? 18.367  -10.691 14.368  1.00 22.72  ? 223 PRO A O    1 
ATOM   3441 C CB   . PRO A 1 259 ? 20.686  -12.041 16.324  1.00 31.00  ? 223 PRO A CB   1 
ATOM   3442 C CG   . PRO A 1 259 ? 21.573  -13.158 16.504  1.00 32.53  ? 223 PRO A CG   1 
ATOM   3443 C CD   . PRO A 1 259 ? 21.890  -13.718 15.168  1.00 29.43  ? 223 PRO A CD   1 
ATOM   3444 H HA   . PRO A 1 259 ? 19.023  -12.859 15.366  1.00 37.82  ? 223 PRO A HA   1 
ATOM   3445 H HB2  . PRO A 1 259 ? 21.182  -11.226 16.152  1.00 37.19  ? 223 PRO A HB2  1 
ATOM   3446 H HB3  . PRO A 1 259 ? 20.112  -11.924 17.097  1.00 37.19  ? 223 PRO A HB3  1 
ATOM   3447 H HG2  . PRO A 1 259 ? 22.384  -12.852 16.939  1.00 39.02  ? 223 PRO A HG2  1 
ATOM   3448 H HG3  . PRO A 1 259 ? 21.134  -13.827 17.052  1.00 39.02  ? 223 PRO A HG3  1 
ATOM   3449 H HD2  . PRO A 1 259 ? 22.686  -13.305 14.798  1.00 35.30  ? 223 PRO A HD2  1 
ATOM   3450 H HD3  . PRO A 1 259 ? 22.007  -14.680 15.214  1.00 35.30  ? 223 PRO A HD3  1 
ATOM   3451 N N    . VAL A 1 260 ? 20.431  -10.627 13.502  1.00 17.87  ? 224 VAL A N    1 
ATOM   3452 C CA   . VAL A 1 260 ? 20.104  -9.390  12.811  1.00 22.88  ? 224 VAL A CA   1 
ATOM   3453 C C    . VAL A 1 260 ? 19.438  -9.653  11.474  1.00 24.47  ? 224 VAL A C    1 
ATOM   3454 O O    . VAL A 1 260 ? 18.945  -8.708  10.852  1.00 21.81  ? 224 VAL A O    1 
ATOM   3455 C CB   . VAL A 1 260 ? 21.342  -8.492  12.614  1.00 25.52  ? 224 VAL A CB   1 
ATOM   3456 C CG1  . VAL A 1 260 ? 21.986  -8.243  13.969  1.00 29.60  ? 224 VAL A CG1  1 
ATOM   3457 C CG2  . VAL A 1 260 ? 22.297  -9.124  11.664  1.00 26.51  ? 224 VAL A CG2  1 
ATOM   3458 H H    . VAL A 1 260 ? 21.223  -10.935 13.373  1.00 21.44  ? 224 VAL A H    1 
ATOM   3459 H HA   . VAL A 1 260 ? 19.485  -8.892  13.367  1.00 27.45  ? 224 VAL A HA   1 
ATOM   3460 H HB   . VAL A 1 260 ? 21.084  -7.640  12.230  1.00 30.61  ? 224 VAL A HB   1 
ATOM   3461 H HG11 . VAL A 1 260 ? 22.697  -7.591  13.865  1.00 35.52  ? 224 VAL A HG11 1 
ATOM   3462 H HG12 . VAL A 1 260 ? 21.314  -7.904  14.580  1.00 35.52  ? 224 VAL A HG12 1 
ATOM   3463 H HG13 . VAL A 1 260 ? 22.349  -9.077  14.304  1.00 35.52  ? 224 VAL A HG13 1 
ATOM   3464 H HG21 . VAL A 1 260 ? 23.155  -8.677  11.733  1.00 31.80  ? 224 VAL A HG21 1 
ATOM   3465 H HG22 . VAL A 1 260 ? 22.394  -10.062 11.891  1.00 31.80  ? 224 VAL A HG22 1 
ATOM   3466 H HG23 . VAL A 1 260 ? 21.950  -9.036  10.762  1.00 31.80  ? 224 VAL A HG23 1 
ATOM   3467 N N    . MET A 1 261 ? 19.366  -10.910 11.044  1.00 21.24  ? 225 MET A N    1 
ATOM   3468 C CA   . MET A 1 261 ? 18.715  -11.254 9.792   1.00 22.27  ? 225 MET A CA   1 
ATOM   3469 C C    . MET A 1 261 ? 17.210  -11.159 9.945   1.00 18.63  ? 225 MET A C    1 
ATOM   3470 O O    . MET A 1 261 ? 16.659  -11.530 10.984  1.00 22.11  ? 225 MET A O    1 
ATOM   3471 C CB   . MET A 1 261 ? 18.988  -12.703 9.387   1.00 22.18  ? 225 MET A CB   1 
ATOM   3472 C CG   . MET A 1 261 ? 20.418  -13.154 9.244   1.00 35.15  ? 225 MET A CG   1 
ATOM   3473 S SD   . MET A 1 261 ? 21.184  -12.590 7.763   1.00 53.40  ? 225 MET A SD   1 
ATOM   3474 C CE   . MET A 1 261 ? 21.826  -11.043 8.382   1.00 27.49  ? 225 MET A CE   1 
ATOM   3475 H H    . MET A 1 261 ? 19.690  -11.586 11.465  1.00 25.48  ? 225 MET A H    1 
ATOM   3476 H HA   . MET A 1 261 ? 19.064  -10.652 9.115   1.00 26.71  ? 225 MET A HA   1 
ATOM   3477 H HB2  . MET A 1 261 ? 18.585  -13.276 10.059  1.00 26.61  ? 225 MET A HB2  1 
ATOM   3478 H HB3  . MET A 1 261 ? 18.566  -12.852 8.527   1.00 26.61  ? 225 MET A HB3  1 
ATOM   3479 H HG2  . MET A 1 261 ? 20.931  -12.812 9.993   1.00 42.17  ? 225 MET A HG2  1 
ATOM   3480 H HG3  . MET A 1 261 ? 20.443  -14.124 9.241   1.00 42.17  ? 225 MET A HG3  1 
ATOM   3481 H HE1  . MET A 1 261 ? 22.320  -10.600 7.675   1.00 32.97  ? 225 MET A HE1  1 
ATOM   3482 H HE2  . MET A 1 261 ? 21.085  -10.485 8.667   1.00 32.97  ? 225 MET A HE2  1 
ATOM   3483 H HE3  . MET A 1 261 ? 22.413  -11.223 9.133   1.00 32.97  ? 225 MET A HE3  1 
ATOM   3484 N N    . ASP A 1 262 ? 16.538  -10.782 8.867   1.00 16.16  ? 226 ASP A N    1 
ATOM   3485 C CA   . ASP A 1 262 ? 15.084  -10.911 8.832   1.00 13.99  ? 226 ASP A CA   1 
ATOM   3486 C C    . ASP A 1 262 ? 14.631  -12.230 8.262   1.00 16.57  ? 226 ASP A C    1 
ATOM   3487 O O    . ASP A 1 262 ? 13.461  -12.609 8.432   1.00 17.99  ? 226 ASP A O    1 
ATOM   3488 C CB   . ASP A 1 262 ? 14.485  -9.775  8.004   1.00 16.24  ? 226 ASP A CB   1 
ATOM   3489 C CG   . ASP A 1 262 ? 14.913  -8.448  8.523   1.00 18.33  ? 226 ASP A CG   1 
ATOM   3490 O OD1  . ASP A 1 262 ? 14.578  -8.171  9.702   1.00 18.44  ? 226 ASP A OD1  1 
ATOM   3491 O OD2  . ASP A 1 262 ? 15.662  -7.733  7.811   1.00 16.47  ? 226 ASP A OD2  1 
ATOM   3492 H H    . ASP A 1 262 ? 16.891  -10.455 8.155   1.00 19.38  ? 226 ASP A H    1 
ATOM   3493 H HA   . ASP A 1 262 ? 14.738  -10.840 9.736   1.00 16.78  ? 226 ASP A HA   1 
ATOM   3494 H HB2  . ASP A 1 262 ? 14.783  -9.855  7.085   1.00 19.48  ? 226 ASP A HB2  1 
ATOM   3495 H HB3  . ASP A 1 262 ? 13.517  -9.822  8.045   1.00 19.48  ? 226 ASP A HB3  1 
ATOM   3496 N N    . ALA A 1 263 ? 15.506  -12.919 7.552   1.00 19.33  ? 227 ALA A N    1 
ATOM   3497 C CA   . ALA A 1 263 ? 15.082  -14.070 6.800   1.00 13.07  ? 227 ALA A CA   1 
ATOM   3498 C C    . ALA A 1 263 ? 16.277  -14.969 6.645   1.00 17.99  ? 227 ALA A C    1 
ATOM   3499 O O    . ALA A 1 263 ? 17.409  -14.512 6.679   1.00 14.64  ? 227 ALA A O    1 
ATOM   3500 C CB   . ALA A 1 263 ? 14.563  -13.670 5.445   1.00 15.57  ? 227 ALA A CB   1 
ATOM   3501 H H    . ALA A 1 263 ? 16.345  -12.737 7.494   1.00 23.19  ? 227 ALA A H    1 
ATOM   3502 H HA   . ALA A 1 263 ? 14.377  -14.542 7.270   1.00 15.68  ? 227 ALA A HA   1 
ATOM   3503 H HB1  . ALA A 1 263 ? 14.286  -14.467 4.965   1.00 18.67  ? 227 ALA A HB1  1 
ATOM   3504 H HB2  . ALA A 1 263 ? 13.807  -13.074 5.559   1.00 18.67  ? 227 ALA A HB2  1 
ATOM   3505 H HB3  . ALA A 1 263 ? 15.270  -13.219 4.957   1.00 18.67  ? 227 ALA A HB3  1 
ATOM   3506 N N    . SER A 1 264 ? 16.012  -16.240 6.429   1.00 15.35  ? 228 SER A N    1 
ATOM   3507 C CA   . SER A 1 264 ? 17.086  -17.194 6.167   1.00 14.36  ? 228 SER A CA   1 
ATOM   3508 C C    . SER A 1 264 ? 16.615  -18.174 5.095   1.00 17.93  ? 228 SER A C    1 
ATOM   3509 O O    . SER A 1 264 ? 15.446  -18.554 5.078   1.00 18.97  ? 228 SER A O    1 
ATOM   3510 C CB   . SER A 1 264 ? 17.462  -17.932 7.428   1.00 19.29  ? 228 SER A CB   1 
ATOM   3511 O OG   . SER A 1 264 ? 18.471  -18.897 7.130   1.00 23.68  ? 228 SER A OG   1 
ATOM   3512 H H    . SER A 1 264 ? 15.223  -16.580 6.427   1.00 18.40  ? 228 SER A H    1 
ATOM   3513 H HA   . SER A 1 264 ? 17.875  -16.740 5.832   1.00 17.22  ? 228 SER A HA   1 
ATOM   3514 H HB2  . SER A 1 264 ? 17.803  -17.300 8.080   1.00 23.14  ? 228 SER A HB2  1 
ATOM   3515 H HB3  . SER A 1 264 ? 16.679  -18.383 7.781   1.00 23.14  ? 228 SER A HB3  1 
ATOM   3516 H HG   . SER A 1 264 ? 18.763  -19.235 7.841   1.00 28.41  ? 228 SER A HG   1 
ATOM   3517 N N    . MET A 1 265 ? 17.535  -18.644 4.245   1.00 17.58  ? 229 MET A N    1 
ATOM   3518 C CA   . MET A 1 265 ? 17.189  -19.554 3.166   1.00 14.93  ? 229 MET A CA   1 
ATOM   3519 C C    . MET A 1 265 ? 17.797  -20.922 3.429   1.00 19.57  ? 229 MET A C    1 
ATOM   3520 O O    . MET A 1 265 ? 18.978  -21.036 3.759   1.00 21.77  ? 229 MET A O    1 
ATOM   3521 C CB   . MET A 1 265 ? 17.617  -19.038 1.777   1.00 17.40  ? 229 MET A CB   1 
ATOM   3522 C CG   . MET A 1 265 ? 17.797  -20.120 0.735   1.00 19.73  ? 229 MET A CG   1 
ATOM   3523 S SD   . MET A 1 265 ? 18.273  -19.606 -0.930  1.00 20.19  ? 229 MET A SD   1 
ATOM   3524 C CE   . MET A 1 265 ? 16.831  -18.917 -1.650  1.00 24.36  ? 229 MET A CE   1 
ATOM   3525 H H    . MET A 1 265 ? 18.371  -18.445 4.280   1.00 21.09  ? 229 MET A H    1 
ATOM   3526 H HA   . MET A 1 265 ? 16.222  -19.627 3.149   1.00 17.90  ? 229 MET A HA   1 
ATOM   3527 H HB2  . MET A 1 265 ? 16.938  -18.427 1.451   1.00 20.87  ? 229 MET A HB2  1 
ATOM   3528 H HB3  . MET A 1 265 ? 18.465  -18.575 1.868   1.00 20.87  ? 229 MET A HB3  1 
ATOM   3529 H HG2  . MET A 1 265 ? 18.488  -20.724 1.049   1.00 23.67  ? 229 MET A HG2  1 
ATOM   3530 H HG3  . MET A 1 265 ? 16.955  -20.595 0.651   1.00 23.67  ? 229 MET A HG3  1 
ATOM   3531 H HE1  . MET A 1 265 ? 17.040  -18.615 -2.548  1.00 29.22  ? 229 MET A HE1  1 
ATOM   3532 H HE2  . MET A 1 265 ? 16.138  -19.595 -1.682  1.00 29.22  ? 229 MET A HE2  1 
ATOM   3533 H HE3  . MET A 1 265 ? 16.536  -18.167 -1.110  1.00 29.22  ? 229 MET A HE3  1 
ATOM   3534 N N    . PHE A 1 266 ? 16.983  -21.946 3.261   1.00 18.62  ? 230 PHE A N    1 
ATOM   3535 C CA   . PHE A 1 266 ? 17.429  -23.331 3.202   1.00 18.39  ? 230 PHE A CA   1 
ATOM   3536 C C    . PHE A 1 266 ? 17.718  -23.633 1.738   1.00 17.65  ? 230 PHE A C    1 
ATOM   3537 O O    . PHE A 1 266 ? 16.803  -23.912 0.966   1.00 16.49  ? 230 PHE A O    1 
ATOM   3538 C CB   . PHE A 1 266 ? 16.332  -24.260 3.732   1.00 17.50  ? 230 PHE A CB   1 
ATOM   3539 C CG   . PHE A 1 266 ? 15.949  -23.994 5.144   1.00 16.34  ? 230 PHE A CG   1 
ATOM   3540 C CD1  . PHE A 1 266 ? 14.949  -23.061 5.446   1.00 19.20  ? 230 PHE A CD1  1 
ATOM   3541 C CD2  . PHE A 1 266 ? 16.530  -24.681 6.170   1.00 16.94  ? 230 PHE A CD2  1 
ATOM   3542 C CE1  . PHE A 1 266 ? 14.611  -22.813 6.801   1.00 22.09  ? 230 PHE A CE1  1 
ATOM   3543 C CE2  . PHE A 1 266 ? 16.196  -24.456 7.491   1.00 16.32  ? 230 PHE A CE2  1 
ATOM   3544 C CZ   . PHE A 1 266 ? 15.243  -23.526 7.816   1.00 23.19  ? 230 PHE A CZ   1 
ATOM   3545 H H    . PHE A 1 266 ? 16.131  -21.865 3.175   1.00 22.33  ? 230 PHE A H    1 
ATOM   3546 H HA   . PHE A 1 266 ? 18.232  -23.453 3.732   1.00 22.06  ? 230 PHE A HA   1 
ATOM   3547 H HB2  . PHE A 1 266 ? 15.539  -24.149 3.185   1.00 20.99  ? 230 PHE A HB2  1 
ATOM   3548 H HB3  . PHE A 1 266 ? 16.647  -25.176 3.679   1.00 20.99  ? 230 PHE A HB3  1 
ATOM   3549 H HD1  . PHE A 1 266 ? 14.510  -22.607 4.764   1.00 23.02  ? 230 PHE A HD1  1 
ATOM   3550 H HD2  . PHE A 1 266 ? 17.173  -25.323 5.972   1.00 20.32  ? 230 PHE A HD2  1 
ATOM   3551 H HE1  . PHE A 1 266 ? 13.967  -22.174 7.011   1.00 26.50  ? 230 PHE A HE1  1 
ATOM   3552 H HE2  . PHE A 1 266 ? 16.620  -24.938 8.164   1.00 19.57  ? 230 PHE A HE2  1 
ATOM   3553 H HZ   . PHE A 1 266 ? 15.021  -23.373 8.706   1.00 27.82  ? 230 PHE A HZ   1 
ATOM   3554 N N    . GLU A 1 267 ? 18.996  -23.648 1.353   1.00 20.83  ? 231 GLU A N    1 
ATOM   3555 C CA   . GLU A 1 267 ? 19.349  -23.732 -0.060  1.00 20.85  ? 231 GLU A CA   1 
ATOM   3556 C C    . GLU A 1 267 ? 19.301  -25.141 -0.649  1.00 24.56  ? 231 GLU A C    1 
ATOM   3557 O O    . GLU A 1 267 ? 19.254  -25.283 -1.889  1.00 20.49  ? 231 GLU A O    1 
ATOM   3558 C CB   . GLU A 1 267 ? 20.765  -23.175 -0.266  1.00 20.82  ? 231 GLU A CB   1 
ATOM   3559 C CG   . GLU A 1 267 ? 21.069  -22.920 -1.730  1.00 21.75  ? 231 GLU A CG   1 
ATOM   3560 C CD   . GLU A 1 267 ? 22.527  -22.636 -1.979  1.00 27.27  ? 231 GLU A CD   1 
ATOM   3561 O OE1  . GLU A 1 267 ? 23.226  -22.313 -1.000  1.00 22.64  ? 231 GLU A OE1  1 
ATOM   3562 O OE2  . GLU A 1 267 ? 22.958  -22.724 -3.154  1.00 29.62  ? 231 GLU A OE2  1 
ATOM   3563 H H    . GLU A 1 267 ? 19.669  -23.611 1.887   1.00 24.98  ? 231 GLU A H    1 
ATOM   3564 H HA   . GLU A 1 267 ? 18.704  -23.196 -0.548  1.00 25.01  ? 231 GLU A HA   1 
ATOM   3565 H HB2  . GLU A 1 267 ? 20.850  -22.335 0.212   1.00 24.98  ? 231 GLU A HB2  1 
ATOM   3566 H HB3  . GLU A 1 267 ? 21.411  -23.815 0.071   1.00 24.98  ? 231 GLU A HB3  1 
ATOM   3567 H HG2  . GLU A 1 267 ? 20.824  -23.704 -2.245  1.00 26.09  ? 231 GLU A HG2  1 
ATOM   3568 H HG3  . GLU A 1 267 ? 20.558  -22.152 -2.030  1.00 26.09  ? 231 GLU A HG3  1 
ATOM   3569 N N    . HIS A 1 268 ? 19.353  -26.170 0.187   1.00 20.21  ? 232 HIS A N    1 
ATOM   3570 C CA   . HIS A 1 268 ? 19.330  -27.551 -0.277  1.00 17.94  ? 232 HIS A CA   1 
ATOM   3571 C C    . HIS A 1 268 ? 20.250  -27.745 -1.473  1.00 30.36  ? 232 HIS A C    1 
ATOM   3572 O O    . HIS A 1 268 ? 19.862  -28.289 -2.509  1.00 25.01  ? 232 HIS A O    1 
ATOM   3573 C CB   . HIS A 1 268 ? 17.896  -27.996 -0.592  1.00 18.99  ? 232 HIS A CB   1 
ATOM   3574 C CG   . HIS A 1 268 ? 16.994  -27.930 0.602   1.00 18.55  ? 232 HIS A CG   1 
ATOM   3575 N ND1  . HIS A 1 268 ? 16.056  -26.928 0.775   1.00 18.43  ? 232 HIS A ND1  1 
ATOM   3576 C CD2  . HIS A 1 268 ? 16.914  -28.714 1.700   1.00 23.88  ? 232 HIS A CD2  1 
ATOM   3577 C CE1  . HIS A 1 268 ? 15.443  -27.101 1.929   1.00 23.65  ? 232 HIS A CE1  1 
ATOM   3578 N NE2  . HIS A 1 268 ? 15.943  -28.178 2.510   1.00 18.91  ? 232 HIS A NE2  1 
ATOM   3579 H H    . HIS A 1 268 ? 19.404  -26.093 1.042   1.00 24.24  ? 232 HIS A H    1 
ATOM   3580 H HA   . HIS A 1 268 ? 19.667  -28.117 0.434   1.00 21.51  ? 232 HIS A HA   1 
ATOM   3581 H HB2  . HIS A 1 268 ? 17.528  -27.418 -1.279  1.00 22.78  ? 232 HIS A HB2  1 
ATOM   3582 H HB3  . HIS A 1 268 ? 17.911  -28.914 -0.906  1.00 22.78  ? 232 HIS A HB3  1 
ATOM   3583 H HD1  . HIS A 1 268 ? 15.898  -26.293 0.217   1.00 22.10  ? 232 HIS A HD1  1 
ATOM   3584 H HD2  . HIS A 1 268 ? 17.421  -29.474 1.875   1.00 28.64  ? 232 HIS A HD2  1 
ATOM   3585 H HE1  . HIS A 1 268 ? 14.773  -26.558 2.275   1.00 28.37  ? 232 HIS A HE1  1 
ATOM   3586 H HE2  . HIS A 1 268 ? 15.699  -28.493 3.272   1.00 22.69  ? 232 HIS A HE2  1 
ATOM   3587 N N    . TYR A 1 269 ? 21.512  -27.316 -1.302  1.00 27.96  ? 233 TYR A N    1 
ATOM   3588 C CA   . TYR A 1 269 ? 22.434  -27.277 -2.430  1.00 33.29  ? 233 TYR A CA   1 
ATOM   3589 C C    . TYR A 1 269 ? 23.095  -28.612 -2.737  1.00 32.37  ? 233 TYR A C    1 
ATOM   3590 O O    . TYR A 1 269 ? 23.845  -28.684 -3.704  1.00 34.60  ? 233 TYR A O    1 
ATOM   3591 C CB   . TYR A 1 269 ? 23.540  -26.243 -2.218  1.00 27.50  ? 233 TYR A CB   1 
ATOM   3592 C CG   . TYR A 1 269 ? 24.226  -26.255 -0.866  1.00 32.58  ? 233 TYR A CG   1 
ATOM   3593 C CD1  . TYR A 1 269 ? 25.306  -27.113 -0.597  1.00 39.14  ? 233 TYR A CD1  1 
ATOM   3594 C CD2  . TYR A 1 269 ? 23.825  -25.379 0.132   1.00 38.22  ? 233 TYR A CD2  1 
ATOM   3595 C CE1  . TYR A 1 269 ? 25.943  -27.094 0.655   1.00 35.73  ? 233 TYR A CE1  1 
ATOM   3596 C CE2  . TYR A 1 269 ? 24.437  -25.355 1.370   1.00 37.79  ? 233 TYR A CE2  1 
ATOM   3597 C CZ   . TYR A 1 269 ? 25.488  -26.200 1.635   1.00 49.15  ? 233 TYR A CZ   1 
ATOM   3598 O OH   . TYR A 1 269 ? 26.056  -26.130 2.895   1.00 50.54  ? 233 TYR A OH   1 
ATOM   3599 H H    . TYR A 1 269 ? 21.843  -27.050 -0.554  1.00 33.54  ? 233 TYR A H    1 
ATOM   3600 H HA   . TYR A 1 269 ? 21.906  -27.007 -3.197  1.00 39.94  ? 233 TYR A HA   1 
ATOM   3601 H HB2  . TYR A 1 269 ? 24.226  -26.394 -2.886  1.00 32.99  ? 233 TYR A HB2  1 
ATOM   3602 H HB3  . TYR A 1 269 ? 23.154  -25.360 -2.332  1.00 32.99  ? 233 TYR A HB3  1 
ATOM   3603 H HD1  . TYR A 1 269 ? 25.603  -27.699 -1.255  1.00 46.95  ? 233 TYR A HD1  1 
ATOM   3604 H HD2  . TYR A 1 269 ? 23.124  -24.792 -0.037  1.00 45.85  ? 233 TYR A HD2  1 
ATOM   3605 H HE1  . TYR A 1 269 ? 26.655  -27.665 0.831   1.00 42.87  ? 233 TYR A HE1  1 
ATOM   3606 H HE2  . TYR A 1 269 ? 24.137  -24.766 2.024   1.00 45.34  ? 233 TYR A HE2  1 
ATOM   3607 H HH   . TYR A 1 269 ? 25.666  -25.545 3.354   1.00 60.63  ? 233 TYR A HH   1 
ATOM   3608 N N    . ASN A 1 270 ? 22.844  -29.670 -1.976  1.00 30.07  ? 234 ASN A N    1 
ATOM   3609 C CA   . ASN A 1 270 ? 23.353  -30.977 -2.359  1.00 34.74  ? 234 ASN A CA   1 
ATOM   3610 C C    . ASN A 1 270 ? 22.438  -32.060 -1.797  1.00 36.60  ? 234 ASN A C    1 
ATOM   3611 O O    . ASN A 1 270 ? 21.415  -31.778 -1.163  1.00 37.37  ? 234 ASN A O    1 
ATOM   3612 C CB   . ASN A 1 270 ? 24.812  -31.160 -1.910  1.00 35.44  ? 234 ASN A CB   1 
ATOM   3613 C CG   . ASN A 1 270 ? 24.969  -31.189 -0.408  1.00 33.86  ? 234 ASN A CG   1 
ATOM   3614 O OD1  . ASN A 1 270 ? 24.055  -31.560 0.327   1.00 34.57  ? 234 ASN A OD1  1 
ATOM   3615 N ND2  . ASN A 1 270 ? 26.153  -30.818 0.059   1.00 41.24  ? 234 ASN A ND2  1 
ATOM   3616 H H    . ASN A 1 270 ? 22.389  -29.655 -1.246  1.00 36.08  ? 234 ASN A H    1 
ATOM   3617 H HA   . ASN A 1 270 ? 23.326  -31.048 -3.326  1.00 41.68  ? 234 ASN A HA   1 
ATOM   3618 H HB2  . ASN A 1 270 ? 25.148  -31.999 -2.261  1.00 42.51  ? 234 ASN A HB2  1 
ATOM   3619 H HB3  . ASN A 1 270 ? 25.342  -30.422 -2.251  1.00 42.51  ? 234 ASN A HB3  1 
ATOM   3620 H HD21 . ASN A 1 270 ? 26.299  -30.815 0.906   1.00 49.48  ? 234 ASN A HD21 1 
ATOM   3621 H HD22 . ASN A 1 270 ? 26.775  -30.580 -0.486  1.00 49.48  ? 234 ASN A HD22 1 
ATOM   3622 N N    . GLU A 1 271 ? 22.815  -33.315 -2.055  1.00 35.77  ? 235 GLU A N    1 
ATOM   3623 C CA   . GLU A 1 271 ? 21.977  -34.445 -1.667  1.00 38.40  ? 235 GLU A CA   1 
ATOM   3624 C C    . GLU A 1 271 ? 21.889  -34.593 -0.157  1.00 33.11  ? 235 GLU A C    1 
ATOM   3625 O O    . GLU A 1 271 ? 20.834  -34.956 0.372   1.00 34.89  ? 235 GLU A O    1 
ATOM   3626 C CB   . GLU A 1 271 ? 22.516  -35.757 -2.250  1.00 50.37  ? 235 GLU A CB   1 
ATOM   3627 C CG   . GLU A 1 271 ? 22.743  -35.766 -3.750  1.00 65.98  ? 235 GLU A CG   1 
ATOM   3628 C CD   . GLU A 1 271 ? 22.258  -37.055 -4.413  1.00 65.49  ? 235 GLU A CD   1 
ATOM   3629 O OE1  . GLU A 1 271 ? 21.929  -38.021 -3.691  1.00 59.40  ? 235 GLU A OE1  1 
ATOM   3630 O OE2  . GLU A 1 271 ? 22.203  -37.098 -5.661  1.00 67.77  ? 235 GLU A OE2  1 
ATOM   3631 H H    . GLU A 1 271 ? 23.546  -33.536 -2.451  1.00 42.91  ? 235 GLU A H    1 
ATOM   3632 H HA   . GLU A 1 271 ? 21.092  -34.277 -2.028  1.00 46.07  ? 235 GLU A HA   1 
ATOM   3633 H HB2  . GLU A 1 271 ? 23.368  -35.950 -1.829  1.00 60.43  ? 235 GLU A HB2  1 
ATOM   3634 H HB3  . GLU A 1 271 ? 21.880  -36.463 -2.051  1.00 60.43  ? 235 GLU A HB3  1 
ATOM   3635 H HG2  . GLU A 1 271 ? 22.260  -35.025 -4.148  1.00 79.17  ? 235 GLU A HG2  1 
ATOM   3636 H HG3  . GLU A 1 271 ? 23.693  -35.677 -3.927  1.00 79.17  ? 235 GLU A HG3  1 
ATOM   3637 N N    . LYS A 1 272 ? 23.001  -34.387 0.548   1.00 30.17  ? 236 LYS A N    1 
ATOM   3638 C CA   . LYS A 1 272 ? 22.980  -34.548 1.999   1.00 36.20  ? 236 LYS A CA   1 
ATOM   3639 C C    . LYS A 1 272 ? 21.938  -33.637 2.634   1.00 29.99  ? 236 LYS A C    1 
ATOM   3640 O O    . LYS A 1 272 ? 21.323  -33.991 3.643   1.00 28.30  ? 236 LYS A O    1 
ATOM   3641 C CB   . LYS A 1 272 ? 24.362  -34.258 2.575   1.00 32.66  ? 236 LYS A CB   1 
ATOM   3642 C CG   . LYS A 1 272 ? 24.407  -33.979 4.086   1.00 39.52  ? 236 LYS A CG   1 
ATOM   3643 C CD   . LYS A 1 272 ? 24.346  -35.251 4.914   1.00 45.17  ? 236 LYS A CD   1 
ATOM   3644 C CE   . LYS A 1 272 ? 24.356  -34.968 6.416   1.00 51.52  ? 236 LYS A CE   1 
ATOM   3645 N NZ   . LYS A 1 272 ? 23.852  -33.607 6.789   1.00 64.24  ? 236 LYS A NZ   1 
ATOM   3646 H H    . LYS A 1 272 ? 23.762  -34.160 0.218   1.00 36.19  ? 236 LYS A H    1 
ATOM   3647 H HA   . LYS A 1 272 ? 22.751  -35.466 2.212   1.00 43.43  ? 236 LYS A HA   1 
ATOM   3648 H HB2  . LYS A 1 272 ? 24.929  -35.027 2.406   1.00 39.18  ? 236 LYS A HB2  1 
ATOM   3649 H HB3  . LYS A 1 272 ? 24.721  -33.476 2.126   1.00 39.18  ? 236 LYS A HB3  1 
ATOM   3650 H HG2  . LYS A 1 272 ? 25.235  -33.521 4.300   1.00 47.41  ? 236 LYS A HG2  1 
ATOM   3651 H HG3  . LYS A 1 272 ? 23.649  -33.425 4.329   1.00 47.41  ? 236 LYS A HG3  1 
ATOM   3652 H HD2  . LYS A 1 272 ? 23.528  -35.729 4.703   1.00 54.20  ? 236 LYS A HD2  1 
ATOM   3653 H HD3  . LYS A 1 272 ? 25.116  -35.803 4.706   1.00 54.20  ? 236 LYS A HD3  1 
ATOM   3654 H HE2  . LYS A 1 272 ? 23.792  -35.621 6.859   1.00 61.81  ? 236 LYS A HE2  1 
ATOM   3655 H HE3  . LYS A 1 272 ? 25.267  -35.042 6.740   1.00 61.81  ? 236 LYS A HE3  1 
ATOM   3656 H HZ1  . LYS A 1 272 ? 23.782  -33.540 7.674   1.00 77.08  ? 236 LYS A HZ1  1 
ATOM   3657 H HZ2  . LYS A 1 272 ? 24.414  -32.983 6.495   1.00 77.08  ? 236 LYS A HZ2  1 
ATOM   3658 H HZ3  . LYS A 1 272 ? 23.051  -33.468 6.425   1.00 77.08  ? 236 LYS A HZ3  1 
ATOM   3659 N N    . LEU A 1 273 ? 21.752  -32.448 2.084   1.00 28.28  ? 237 LEU A N    1 
ATOM   3660 C CA   . LEU A 1 273 ? 20.816  -31.533 2.704   1.00 22.19  ? 237 LEU A CA   1 
ATOM   3661 C C    . LEU A 1 273 ? 19.376  -31.893 2.408   1.00 23.07  ? 237 LEU A C    1 
ATOM   3662 O O    . LEU A 1 273 ? 18.485  -31.216 2.920   1.00 22.32  ? 237 LEU A O    1 
ATOM   3663 C CB   . LEU A 1 273 ? 21.074  -30.101 2.245   1.00 24.46  ? 237 LEU A CB   1 
ATOM   3664 C CG   . LEU A 1 273 ? 22.403  -29.528 2.700   1.00 29.96  ? 237 LEU A CG   1 
ATOM   3665 C CD1  . LEU A 1 273 ? 22.654  -28.214 2.007   1.00 32.46  ? 237 LEU A CD1  1 
ATOM   3666 C CD2  . LEU A 1 273 ? 22.377  -29.343 4.186   1.00 31.64  ? 237 LEU A CD2  1 
ATOM   3667 H H    . LEU A 1 273 ? 22.144  -32.160 1.375   1.00 33.93  ? 237 LEU A H    1 
ATOM   3668 H HA   . LEU A 1 273 ? 20.954  -31.562 3.664   1.00 26.62  ? 237 LEU A HA   1 
ATOM   3669 H HB2  . LEU A 1 273 ? 21.061  -30.081 1.275   1.00 29.34  ? 237 LEU A HB2  1 
ATOM   3670 H HB3  . LEU A 1 273 ? 20.372  -29.532 2.598   1.00 29.34  ? 237 LEU A HB3  1 
ATOM   3671 H HG   . LEU A 1 273 ? 23.127  -30.132 2.474   1.00 35.94  ? 237 LEU A HG   1 
ATOM   3672 H HD11 . LEU A 1 273 ? 23.453  -27.809 2.378   1.00 38.94  ? 237 LEU A HD11 1 
ATOM   3673 H HD12 . LEU A 1 273 ? 22.774  -28.375 1.058   1.00 38.94  ? 237 LEU A HD12 1 
ATOM   3674 H HD13 . LEU A 1 273 ? 21.891  -27.631 2.150   1.00 38.94  ? 237 LEU A HD13 1 
ATOM   3675 H HD21 . LEU A 1 273 ? 23.139  -28.804 4.451   1.00 37.96  ? 237 LEU A HD21 1 
ATOM   3676 H HD22 . LEU A 1 273 ? 21.553  -28.896 4.435   1.00 37.96  ? 237 LEU A HD22 1 
ATOM   3677 H HD23 . LEU A 1 273 ? 22.423  -30.213 4.613   1.00 37.96  ? 237 LEU A HD23 1 
ATOM   3678 N N    . LEU A 1 274 ? 19.139  -32.900 1.571   1.00 25.73  ? 238 LEU A N    1 
ATOM   3679 C CA   . LEU A 1 274 ? 17.793  -33.389 1.297   1.00 28.11  ? 238 LEU A CA   1 
ATOM   3680 C C    . LEU A 1 274 ? 17.526  -34.750 1.929   1.00 28.45  ? 238 LEU A C    1 
ATOM   3681 O O    . LEU A 1 274 ? 16.484  -35.351 1.658   1.00 27.72  ? 238 LEU A O    1 
ATOM   3682 C CB   . LEU A 1 274 ? 17.534  -33.452 -0.210  1.00 25.73  ? 238 LEU A CB   1 
ATOM   3683 C CG   . LEU A 1 274 ? 17.642  -32.175 -1.046  1.00 31.09  ? 238 LEU A CG   1 
ATOM   3684 C CD1  . LEU A 1 274 ? 17.856  -32.470 -2.526  1.00 34.35  ? 238 LEU A CD1  1 
ATOM   3685 C CD2  . LEU A 1 274 ? 16.364  -31.370 -0.838  1.00 37.23  ? 238 LEU A CD2  1 
ATOM   3686 H H    . LEU A 1 274 ? 19.753  -33.323 1.143   1.00 30.86  ? 238 LEU A H    1 
ATOM   3687 H HA   . LEU A 1 274 ? 17.163  -32.756 1.675   1.00 33.72  ? 238 LEU A HA   1 
ATOM   3688 H HB2  . LEU A 1 274 ? 18.172  -34.079 -0.586  1.00 30.87  ? 238 LEU A HB2  1 
ATOM   3689 H HB3  . LEU A 1 274 ? 16.631  -33.784 -0.334  1.00 30.87  ? 238 LEU A HB3  1 
ATOM   3690 H HG   . LEU A 1 274 ? 18.415  -31.663 -0.763  1.00 37.30  ? 238 LEU A HG   1 
ATOM   3691 H HD11 . LEU A 1 274 ? 17.938  -31.631 -3.006  1.00 41.21  ? 238 LEU A HD11 1 
ATOM   3692 H HD12 . LEU A 1 274 ? 18.667  -32.992 -2.630  1.00 41.21  ? 238 LEU A HD12 1 
ATOM   3693 H HD13 . LEU A 1 274 ? 17.095  -32.970 -2.861  1.00 41.21  ? 238 LEU A HD13 1 
ATOM   3694 H HD21 . LEU A 1 274 ? 16.416  -30.555 -1.360  1.00 44.66  ? 238 LEU A HD21 1 
ATOM   3695 H HD22 . LEU A 1 274 ? 15.606  -31.901 -1.127  1.00 44.66  ? 238 LEU A HD22 1 
ATOM   3696 H HD23 . LEU A 1 274 ? 16.277  -31.155 0.104   1.00 44.66  ? 238 LEU A HD23 1 
ATOM   3697 N N    . SER A 1 275 ? 18.415  -35.224 2.785   1.00 28.56  ? 239 SER A N    1 
ATOM   3698 C CA   . SER A 1 275 ? 18.188  -36.452 3.516   1.00 27.62  ? 239 SER A CA   1 
ATOM   3699 C C    . SER A 1 275 ? 17.012  -36.314 4.476   1.00 29.20  ? 239 SER A C    1 
ATOM   3700 O O    . SER A 1 275 ? 16.594  -35.214 4.835   1.00 24.26  ? 239 SER A O    1 
ATOM   3701 C CB   . SER A 1 275 ? 19.426  -36.813 4.310   1.00 30.09  ? 239 SER A CB   1 
ATOM   3702 O OG   . SER A 1 275 ? 19.627  -35.872 5.349   1.00 27.63  ? 239 SER A OG   1 
ATOM   3703 H H    . SER A 1 275 ? 19.167  -34.848 2.962   1.00 34.26  ? 239 SER A H    1 
ATOM   3704 H HA   . SER A 1 275 ? 17.986  -37.161 2.886   1.00 33.13  ? 239 SER A HA   1 
ATOM   3705 H HB2  . SER A 1 275 ? 19.312  -37.695 4.696   1.00 36.10  ? 239 SER A HB2  1 
ATOM   3706 H HB3  . SER A 1 275 ? 20.196  -36.806 3.720   1.00 36.10  ? 239 SER A HB3  1 
ATOM   3707 H HG   . SER A 1 275 ? 20.103  -36.209 5.953   1.00 33.15  ? 239 SER A HG   1 
ATOM   3708 N N    . LYS A 1 276 ? 16.493  -37.461 4.919   1.00 28.26  ? 240 LYS A N    1 
ATOM   3709 C CA   . LYS A 1 276 ? 15.386  -37.435 5.870   1.00 26.23  ? 240 LYS A CA   1 
ATOM   3710 C C    . LYS A 1 276 ? 15.794  -36.748 7.164   1.00 29.11  ? 240 LYS A C    1 
ATOM   3711 O O    . LYS A 1 276 ? 15.003  -36.006 7.765   1.00 25.56  ? 240 LYS A O    1 
ATOM   3712 C CB   . LYS A 1 276 ? 14.882  -38.859 6.155   1.00 31.52  ? 240 LYS A CB   1 
ATOM   3713 C CG   . LYS A 1 276 ? 15.954  -39.783 6.654   1.00 26.30  ? 240 LYS A CG   1 
ATOM   3714 C CD   . LYS A 1 276 ? 15.496  -41.252 6.661   1.00 33.81  ? 240 LYS A CD   1 
ATOM   3715 C CE   . LYS A 1 276 ? 16.351  -42.108 7.615   1.00 38.42  ? 240 LYS A CE   1 
ATOM   3716 N NZ   . LYS A 1 276 ? 17.765  -42.301 7.141   1.00 35.08  ? 240 LYS A NZ   1 
ATOM   3717 H H    . LYS A 1 276 ? 16.758  -38.247 4.691   1.00 33.90  ? 240 LYS A H    1 
ATOM   3718 H HA   . LYS A 1 276 ? 14.654  -36.937 5.474   1.00 31.46  ? 240 LYS A HA   1 
ATOM   3719 H HB2  . LYS A 1 276 ? 14.188  -38.816 6.832   1.00 37.81  ? 240 LYS A HB2  1 
ATOM   3720 H HB3  . LYS A 1 276 ? 14.524  -39.235 5.336   1.00 37.81  ? 240 LYS A HB3  1 
ATOM   3721 H HG2  . LYS A 1 276 ? 16.731  -39.711 6.078   1.00 31.55  ? 240 LYS A HG2  1 
ATOM   3722 H HG3  . LYS A 1 276 ? 16.190  -39.536 7.562   1.00 31.55  ? 240 LYS A HG3  1 
ATOM   3723 H HD2  . LYS A 1 276 ? 14.573  -41.299 6.954   1.00 40.56  ? 240 LYS A HD2  1 
ATOM   3724 H HD3  . LYS A 1 276 ? 15.579  -41.617 5.766   1.00 40.56  ? 240 LYS A HD3  1 
ATOM   3725 H HE2  . LYS A 1 276 ? 16.384  -41.674 8.481   1.00 46.09  ? 240 LYS A HE2  1 
ATOM   3726 H HE3  . LYS A 1 276 ? 15.944  -42.985 7.699   1.00 46.09  ? 240 LYS A HE3  1 
ATOM   3727 H HZ1  . LYS A 1 276 ? 18.205  -42.832 7.704   1.00 42.09  ? 240 LYS A HZ1  1 
ATOM   3728 H HZ2  . LYS A 1 276 ? 17.768  -42.671 6.332   1.00 42.09  ? 240 LYS A HZ2  1 
ATOM   3729 H HZ3  . LYS A 1 276 ? 18.182  -41.515 7.101   1.00 42.09  ? 240 LYS A HZ3  1 
ATOM   3730 N N    . GLU A 1 277 ? 17.044  -36.940 7.589   1.00 28.73  ? 241 GLU A N    1 
ATOM   3731 C CA   . GLU A 1 277 ? 17.506  -36.269 8.794   1.00 21.88  ? 241 GLU A CA   1 
ATOM   3732 C C    . GLU A 1 277 ? 17.590  -34.759 8.582   1.00 25.94  ? 241 GLU A C    1 
ATOM   3733 O O    . GLU A 1 277 ? 17.227  -33.980 9.469   1.00 26.03  ? 241 GLU A O    1 
ATOM   3734 C CB   . GLU A 1 277 ? 18.861  -36.821 9.224   1.00 29.83  ? 241 GLU A CB   1 
ATOM   3735 C CG   . GLU A 1 277 ? 18.799  -38.276 9.626   1.00 29.44  ? 241 GLU A CG   1 
ATOM   3736 C CD   . GLU A 1 277 ? 18.977  -39.212 8.465   1.00 30.55  ? 241 GLU A CD   1 
ATOM   3737 O OE1  . GLU A 1 277 ? 19.196  -38.739 7.337   1.00 25.64  ? 241 GLU A OE1  1 
ATOM   3738 O OE2  . GLU A 1 277 ? 18.866  -40.442 8.678   1.00 34.93  ? 241 GLU A OE2  1 
ATOM   3739 H H    . GLU A 1 277 ? 17.627  -37.441 7.204   1.00 34.47  ? 241 GLU A H    1 
ATOM   3740 H HA   . GLU A 1 277 ? 16.874  -36.445 9.509   1.00 26.24  ? 241 GLU A HA   1 
ATOM   3741 H HB2  . GLU A 1 277 ? 19.484  -36.740 8.485   1.00 35.79  ? 241 GLU A HB2  1 
ATOM   3742 H HB3  . GLU A 1 277 ? 19.181  -36.312 9.986   1.00 35.79  ? 241 GLU A HB3  1 
ATOM   3743 H HG2  . GLU A 1 277 ? 19.505  -38.457 10.267  1.00 35.32  ? 241 GLU A HG2  1 
ATOM   3744 H HG3  . GLU A 1 277 ? 17.934  -38.457 10.026  1.00 35.32  ? 241 GLU A HG3  1 
ATOM   3745 N N    . SER A 1 278 ? 18.070  -34.338 7.408   1.00 23.12  ? 242 SER A N    1 
ATOM   3746 C CA   . SER A 1 278 ? 18.226  -32.909 7.140   1.00 27.83  ? 242 SER A CA   1 
ATOM   3747 C C    . SER A 1 278 ? 16.883  -32.223 7.007   1.00 26.03  ? 242 SER A C    1 
ATOM   3748 O O    . SER A 1 278 ? 16.746  -31.055 7.380   1.00 24.06  ? 242 SER A O    1 
ATOM   3749 C CB   . SER A 1 278 ? 19.025  -32.691 5.861   1.00 26.47  ? 242 SER A CB   1 
ATOM   3750 O OG   . SER A 1 278 ? 20.385  -32.971 6.108   1.00 27.01  ? 242 SER A OG   1 
ATOM   3751 H H    . SER A 1 278 ? 18.309  -34.852 6.762   1.00 27.74  ? 242 SER A H    1 
ATOM   3752 H HA   . SER A 1 278 ? 18.710  -32.516 7.882   1.00 33.38  ? 242 SER A HA   1 
ATOM   3753 H HB2  . SER A 1 278 ? 18.694  -33.286 5.169   1.00 31.75  ? 242 SER A HB2  1 
ATOM   3754 H HB3  . SER A 1 278 ? 18.933  -31.769 5.576   1.00 31.75  ? 242 SER A HB3  1 
ATOM   3755 H HG   . SER A 1 278 ? 20.797  -33.058 5.381   1.00 32.40  ? 242 SER A HG   1 
ATOM   3756 N N    . LEU A 1 279 ? 15.915  -32.911 6.399   1.00 25.62  ? 243 LEU A N    1 
ATOM   3757 C CA   . LEU A 1 279 ? 14.573  -32.353 6.243   1.00 21.70  ? 243 LEU A CA   1 
ATOM   3758 C C    . LEU A 1 279 ? 13.894  -32.183 7.597   1.00 22.34  ? 243 LEU A C    1 
ATOM   3759 O O    . LEU A 1 279 ? 13.196  -31.184 7.829   1.00 22.42  ? 243 LEU A O    1 
ATOM   3760 C CB   . LEU A 1 279 ? 13.757  -33.236 5.305   1.00 27.11  ? 243 LEU A CB   1 
ATOM   3761 C CG   . LEU A 1 279 ? 14.201  -33.142 3.840   1.00 26.24  ? 243 LEU A CG   1 
ATOM   3762 C CD1  . LEU A 1 279 ? 13.535  -34.184 2.992   1.00 25.64  ? 243 LEU A CD1  1 
ATOM   3763 C CD2  . LEU A 1 279 ? 13.911  -31.747 3.266   1.00 24.48  ? 243 LEU A CD2  1 
ATOM   3764 H H    . LEU A 1 279 ? 16.009  -33.700 6.069   1.00 30.73  ? 243 LEU A H    1 
ATOM   3765 H HA   . LEU A 1 279 ? 14.627  -31.474 5.837   1.00 26.03  ? 243 LEU A HA   1 
ATOM   3766 H HB2  . LEU A 1 279 ? 13.850  -34.160 5.585   1.00 32.52  ? 243 LEU A HB2  1 
ATOM   3767 H HB3  . LEU A 1 279 ? 12.827  -32.967 5.352   1.00 32.52  ? 243 LEU A HB3  1 
ATOM   3768 H HG   . LEU A 1 279 ? 15.158  -33.299 3.813   1.00 31.47  ? 243 LEU A HG   1 
ATOM   3769 H HD11 . LEU A 1 279 ? 13.842  -34.090 2.077   1.00 30.76  ? 243 LEU A HD11 1 
ATOM   3770 H HD12 . LEU A 1 279 ? 13.770  -35.063 3.330   1.00 30.76  ? 243 LEU A HD12 1 
ATOM   3771 H HD13 . LEU A 1 279 ? 12.574  -34.059 3.034   1.00 30.76  ? 243 LEU A HD13 1 
ATOM   3772 H HD21 . LEU A 1 279 ? 13.982  -31.782 2.299   1.00 29.37  ? 243 LEU A HD21 1 
ATOM   3773 H HD22 . LEU A 1 279 ? 13.015  -31.480 3.523   1.00 29.37  ? 243 LEU A HD22 1 
ATOM   3774 H HD23 . LEU A 1 279 ? 14.558  -31.118 3.622   1.00 29.37  ? 243 LEU A HD23 1 
ATOM   3775 N N    . LEU A 1 280 ? 14.072  -33.140 8.505   1.00 22.00  ? 244 LEU A N    1 
ATOM   3776 C CA   . LEU A 1 280 ? 13.525  -32.970 9.849   1.00 20.10  ? 244 LEU A CA   1 
ATOM   3777 C C    . LEU A 1 280 ? 14.181  -31.792 10.547  1.00 24.37  ? 244 LEU A C    1 
ATOM   3778 O O    . LEU A 1 280 ? 13.511  -30.976 11.187  1.00 23.65  ? 244 LEU A O    1 
ATOM   3779 C CB   . LEU A 1 280 ? 13.708  -34.265 10.650  1.00 23.28  ? 244 LEU A CB   1 
ATOM   3780 C CG   . LEU A 1 280 ? 13.306  -34.240 12.127  1.00 23.45  ? 244 LEU A CG   1 
ATOM   3781 C CD1  . LEU A 1 280 ? 11.830  -33.847 12.326  1.00 26.36  ? 244 LEU A CD1  1 
ATOM   3782 C CD2  . LEU A 1 280 ? 13.579  -35.599 12.760  1.00 29.81  ? 244 LEU A CD2  1 
ATOM   3783 H H    . LEU A 1 280 ? 14.494  -33.878 8.372   1.00 26.38  ? 244 LEU A H    1 
ATOM   3784 H HA   . LEU A 1 280 ? 12.573  -32.792 9.794   1.00 24.11  ? 244 LEU A HA   1 
ATOM   3785 H HB2  . LEU A 1 280 ? 13.174  -34.955 10.226  1.00 27.93  ? 244 LEU A HB2  1 
ATOM   3786 H HB3  . LEU A 1 280 ? 14.647  -34.505 10.618  1.00 27.93  ? 244 LEU A HB3  1 
ATOM   3787 H HG   . LEU A 1 280 ? 13.839  -33.563 12.573  1.00 28.13  ? 244 LEU A HG   1 
ATOM   3788 H HD11 . LEU A 1 280 ? 11.603  -33.934 13.265  1.00 31.62  ? 244 LEU A HD11 1 
ATOM   3789 H HD12 . LEU A 1 280 ? 11.706  -32.928 12.040  1.00 31.62  ? 244 LEU A HD12 1 
ATOM   3790 H HD13 . LEU A 1 280 ? 11.272  -34.436 11.795  1.00 31.62  ? 244 LEU A HD13 1 
ATOM   3791 H HD21 . LEU A 1 280 ? 13.305  -35.574 13.691  1.00 35.76  ? 244 LEU A HD21 1 
ATOM   3792 H HD22 . LEU A 1 280 ? 13.074  -36.276 12.284  1.00 35.76  ? 244 LEU A HD22 1 
ATOM   3793 H HD23 . LEU A 1 280 ? 14.528  -35.790 12.700  1.00 35.76  ? 244 LEU A HD23 1 
ATOM   3794 N N    . GLN A 1 281 ? 15.503  -31.664 10.411  1.00 23.98  ? 245 GLN A N    1 
ATOM   3795 C CA   . GLN A 1 281 ? 16.176  -30.482 10.910  1.00 24.89  ? 245 GLN A CA   1 
ATOM   3796 C C    . GLN A 1 281 ? 15.618  -29.210 10.274  1.00 20.82  ? 245 GLN A C    1 
ATOM   3797 O O    . GLN A 1 281 ? 15.431  -28.204 10.966  1.00 20.63  ? 245 GLN A O    1 
ATOM   3798 C CB   . GLN A 1 281 ? 17.676  -30.595 10.650  1.00 24.95  ? 245 GLN A CB   1 
ATOM   3799 C CG   . GLN A 1 281 ? 18.497  -29.539 11.346  1.00 27.04  ? 245 GLN A CG   1 
ATOM   3800 C CD   . GLN A 1 281 ? 18.320  -29.574 12.850  1.00 32.89  ? 245 GLN A CD   1 
ATOM   3801 O OE1  . GLN A 1 281 ? 18.418  -30.631 13.471  1.00 40.49  ? 245 GLN A OE1  1 
ATOM   3802 N NE2  . GLN A 1 281 ? 18.038  -28.428 13.440  1.00 30.78  ? 245 GLN A NE2  1 
ATOM   3803 H H    . GLN A 1 281 ? 16.019  -32.242 10.038  1.00 28.77  ? 245 GLN A H    1 
ATOM   3804 H HA   . GLN A 1 281 ? 16.032  -30.424 11.867  1.00 29.86  ? 245 GLN A HA   1 
ATOM   3805 H HB2  . GLN A 1 281 ? 17.982  -31.461 10.962  1.00 29.93  ? 245 GLN A HB2  1 
ATOM   3806 H HB3  . GLN A 1 281 ? 17.834  -30.511 9.696   1.00 29.93  ? 245 GLN A HB3  1 
ATOM   3807 H HG2  . GLN A 1 281 ? 19.436  -29.685 11.149  1.00 32.44  ? 245 GLN A HG2  1 
ATOM   3808 H HG3  . GLN A 1 281 ? 18.224  -28.664 11.030  1.00 32.44  ? 245 GLN A HG3  1 
ATOM   3809 H HE21 . GLN A 1 281 ? 17.964  -27.710 12.973  1.00 36.92  ? 245 GLN A HE21 1 
ATOM   3810 H HE22 . GLN A 1 281 ? 17.928  -28.399 14.293  1.00 36.92  ? 245 GLN A HE22 1 
ATOM   3811 N N    . ASP A 1 282 ? 15.419  -29.217 8.946   1.00 19.24  ? 246 ASP A N    1 
ATOM   3812 C CA   . ASP A 1 282 ? 14.762  -28.079 8.287   1.00 19.91  ? 246 ASP A CA   1 
ATOM   3813 C C    . ASP A 1 282 ? 13.485  -27.705 9.015   1.00 21.68  ? 246 ASP A C    1 
ATOM   3814 O O    . ASP A 1 282 ? 13.244  -26.537 9.354   1.00 19.52  ? 246 ASP A O    1 
ATOM   3815 C CB   . ASP A 1 282 ? 14.388  -28.385 6.838   1.00 20.58  ? 246 ASP A CB   1 
ATOM   3816 C CG   . ASP A 1 282 ? 15.574  -28.465 5.890   1.00 23.23  ? 246 ASP A CG   1 
ATOM   3817 O OD1  . ASP A 1 282 ? 16.694  -28.096 6.234   1.00 21.51  ? 246 ASP A OD1  1 
ATOM   3818 O OD2  . ASP A 1 282 ? 15.350  -28.877 4.738   1.00 23.89  ? 246 ASP A OD2  1 
ATOM   3819 H H    . ASP A 1 282 ? 15.650  -29.854 8.416   1.00 23.08  ? 246 ASP A H    1 
ATOM   3820 H HA   . ASP A 1 282 ? 15.402  -27.350 8.294   1.00 23.88  ? 246 ASP A HA   1 
ATOM   3821 H HB2  . ASP A 1 282 ? 13.932  -29.241 6.810   1.00 24.69  ? 246 ASP A HB2  1 
ATOM   3822 H HB3  . ASP A 1 282 ? 13.800  -27.685 6.515   1.00 24.69  ? 246 ASP A HB3  1 
ATOM   3823 N N    . TRP A 1 283 ? 12.635  -28.697 9.250   1.00 18.43  ? 247 TRP A N    1 
ATOM   3824 C CA   . TRP A 1 283 ? 11.337  -28.387 9.834   1.00 19.50  ? 247 TRP A CA   1 
ATOM   3825 C C    . TRP A 1 283 ? 11.521  -27.848 11.238  1.00 17.04  ? 247 TRP A C    1 
ATOM   3826 O O    . TRP A 1 283 ? 10.892  -26.858 11.613  1.00 17.18  ? 247 TRP A O    1 
ATOM   3827 C CB   . TRP A 1 283 ? 10.441  -29.622 9.823   1.00 17.89  ? 247 TRP A CB   1 
ATOM   3828 C CG   . TRP A 1 283 ? 10.225  -30.190 8.477   1.00 18.29  ? 247 TRP A CG   1 
ATOM   3829 C CD1  . TRP A 1 283 ? 10.223  -29.523 7.292   1.00 20.68  ? 247 TRP A CD1  1 
ATOM   3830 C CD2  . TRP A 1 283 ? 10.012  -31.573 8.157   1.00 19.37  ? 247 TRP A CD2  1 
ATOM   3831 N NE1  . TRP A 1 283 ? 10.016  -30.389 6.259   1.00 20.31  ? 247 TRP A NE1  1 
ATOM   3832 C CE2  . TRP A 1 283 ? 9.902   -31.662 6.763   1.00 18.07  ? 247 TRP A CE2  1 
ATOM   3833 C CE3  . TRP A 1 283 ? 9.931   -32.738 8.915   1.00 20.66  ? 247 TRP A CE3  1 
ATOM   3834 C CZ2  . TRP A 1 283 ? 9.692   -32.852 6.111   1.00 20.38  ? 247 TRP A CZ2  1 
ATOM   3835 C CZ3  . TRP A 1 283 ? 9.719   -33.930 8.262   1.00 18.31  ? 247 TRP A CZ3  1 
ATOM   3836 C CH2  . TRP A 1 283 ? 9.598   -33.981 6.873   1.00 18.12  ? 247 TRP A CH2  1 
ATOM   3837 H H    . TRP A 1 283 ? 12.780  -29.529 9.087   1.00 22.10  ? 247 TRP A H    1 
ATOM   3838 H HA   . TRP A 1 283 ? 10.887  -27.713 9.302   1.00 23.39  ? 247 TRP A HA   1 
ATOM   3839 H HB2  . TRP A 1 283 ? 10.851  -30.309 10.372  1.00 21.46  ? 247 TRP A HB2  1 
ATOM   3840 H HB3  . TRP A 1 283 ? 9.574   -29.382 10.185  1.00 21.46  ? 247 TRP A HB3  1 
ATOM   3841 H HD1  . TRP A 1 283 ? 10.345  -28.606 7.200   1.00 24.80  ? 247 TRP A HD1  1 
ATOM   3842 H HE1  . TRP A 1 283 ? 9.966   -30.173 5.427   1.00 24.36  ? 247 TRP A HE1  1 
ATOM   3843 H HE3  . TRP A 1 283 ? 10.018  -32.711 9.841   1.00 24.78  ? 247 TRP A HE3  1 
ATOM   3844 H HZ2  . TRP A 1 283 ? 9.617   -32.887 5.184   1.00 24.44  ? 247 TRP A HZ2  1 
ATOM   3845 H HZ3  . TRP A 1 283 ? 9.656   -34.716 8.755   1.00 21.96  ? 247 TRP A HZ3  1 
ATOM   3846 H HH2  . TRP A 1 283 ? 9.450   -34.800 6.457   1.00 21.74  ? 247 TRP A HH2  1 
ATOM   3847 N N    . ASP A 1 284 ? 12.457  -28.422 12.001  1.00 16.22  ? 248 ASP A N    1 
ATOM   3848 C CA   . ASP A 1 284 ? 12.748  -27.852 13.310  1.00 18.42  ? 248 ASP A CA   1 
ATOM   3849 C C    . ASP A 1 284 ? 13.198  -26.405 13.174  1.00 17.47  ? 248 ASP A C    1 
ATOM   3850 O O    . ASP A 1 284 ? 12.741  -25.517 13.904  1.00 19.54  ? 248 ASP A O    1 
ATOM   3851 C CB   . ASP A 1 284 ? 13.870  -28.626 14.006  1.00 22.71  ? 248 ASP A CB   1 
ATOM   3852 C CG   . ASP A 1 284 ? 13.459  -30.010 14.460  1.00 32.44  ? 248 ASP A CG   1 
ATOM   3853 O OD1  . ASP A 1 284 ? 12.236  -30.301 14.502  1.00 25.31  ? 248 ASP A OD1  1 
ATOM   3854 O OD2  . ASP A 1 284 ? 14.394  -30.791 14.804  1.00 32.43  ? 248 ASP A OD2  1 
ATOM   3855 H H    . ASP A 1 284 ? 12.918  -29.116 11.788  1.00 19.45  ? 248 ASP A H    1 
ATOM   3856 H HA   . ASP A 1 284 ? 11.939  -27.913 13.842  1.00 22.10  ? 248 ASP A HA   1 
ATOM   3857 H HB2  . ASP A 1 284 ? 14.612  -28.724 13.390  1.00 27.25  ? 248 ASP A HB2  1 
ATOM   3858 H HB3  . ASP A 1 284 ? 14.153  -28.129 14.790  1.00 27.25  ? 248 ASP A HB3  1 
ATOM   3859 N N    . ASP A 1 285 ? 14.129  -26.167 12.253  1.00 20.45  ? 249 ASP A N    1 
ATOM   3860 C CA   . ASP A 1 285 ? 14.686  -24.826 12.085  1.00 20.70  ? 249 ASP A CA   1 
ATOM   3861 C C    . ASP A 1 285 ? 13.603  -23.847 11.646  1.00 16.80  ? 249 ASP A C    1 
ATOM   3862 O O    . ASP A 1 285 ? 13.600  -22.672 12.051  1.00 19.40  ? 249 ASP A O    1 
ATOM   3863 C CB   . ASP A 1 285 ? 15.813  -24.806 11.049  1.00 21.57  ? 249 ASP A CB   1 
ATOM   3864 C CG   . ASP A 1 285 ? 17.063  -25.571 11.476  1.00 27.15  ? 249 ASP A CG   1 
ATOM   3865 O OD1  . ASP A 1 285 ? 17.258  -25.847 12.683  1.00 24.08  ? 249 ASP A OD1  1 
ATOM   3866 O OD2  . ASP A 1 285 ? 17.847  -25.891 10.554  1.00 24.87  ? 249 ASP A OD2  1 
ATOM   3867 H H    . ASP A 1 285 ? 14.453  -26.757 11.717  1.00 24.53  ? 249 ASP A H    1 
ATOM   3868 H HA   . ASP A 1 285 ? 15.058  -24.556 12.940  1.00 24.83  ? 249 ASP A HA   1 
ATOM   3869 H HB2  . ASP A 1 285 ? 15.488  -25.207 10.228  1.00 25.88  ? 249 ASP A HB2  1 
ATOM   3870 H HB3  . ASP A 1 285 ? 16.072  -23.885 10.889  1.00 25.88  ? 249 ASP A HB3  1 
ATOM   3871 N N    . MET A 1 286 ? 12.708  -24.298 10.769  1.00 18.11  ? 250 MET A N    1 
ATOM   3872 C CA   . MET A 1 286 ? 11.673  -23.404 10.247  1.00 15.91  ? 250 MET A CA   1 
ATOM   3873 C C    . MET A 1 286 ? 10.762  -22.918 11.379  1.00 18.03  ? 250 MET A C    1 
ATOM   3874 O O    . MET A 1 286 ? 10.350  -21.746 11.419  1.00 15.99  ? 250 MET A O    1 
ATOM   3875 C CB   . MET A 1 286 ? 10.888  -24.135 9.163   1.00 15.83  ? 250 MET A CB   1 
ATOM   3876 C CG   . MET A 1 286 ? 11.598  -24.262 7.799   1.00 18.48  ? 250 MET A CG   1 
ATOM   3877 S SD   . MET A 1 286 ? 10.873  -25.537 6.751   1.00 20.62  ? 250 MET A SD   1 
ATOM   3878 C CE   . MET A 1 286 ? 9.597   -24.445 6.165   1.00 18.81  ? 250 MET A CE   1 
ATOM   3879 H H    . MET A 1 286 ? 12.677  -25.101 10.464  1.00 21.72  ? 250 MET A H    1 
ATOM   3880 H HA   . MET A 1 286 ? 12.081  -22.626 9.836   1.00 19.08  ? 250 MET A HA   1 
ATOM   3881 H HB2  . MET A 1 286 ? 10.700  -25.034 9.475   1.00 18.98  ? 250 MET A HB2  1 
ATOM   3882 H HB3  . MET A 1 286 ? 10.058  -23.656 9.012   1.00 18.98  ? 250 MET A HB3  1 
ATOM   3883 H HG2  . MET A 1 286 ? 11.534  -23.415 7.329   1.00 22.16  ? 250 MET A HG2  1 
ATOM   3884 H HG3  . MET A 1 286 ? 12.530  -24.489 7.948   1.00 22.16  ? 250 MET A HG3  1 
ATOM   3885 H HE1  . MET A 1 286 ? 9.022   -24.930 5.553   1.00 22.56  ? 250 MET A HE1  1 
ATOM   3886 H HE2  . MET A 1 286 ? 9.080   -24.128 6.922   1.00 22.56  ? 250 MET A HE2  1 
ATOM   3887 H HE3  . MET A 1 286 ? 10.009  -23.694 5.708   1.00 22.56  ? 250 MET A HE3  1 
ATOM   3888 N N    . LEU A 1 287 ? 10.429  -23.809 12.309  1.00 18.40  ? 251 LEU A N    1 
ATOM   3889 C CA   . LEU A 1 287 ? 9.685   -23.402 13.492  1.00 17.66  ? 251 LEU A CA   1 
ATOM   3890 C C    . LEU A 1 287 ? 10.505  -22.423 14.318  1.00 21.24  ? 251 LEU A C    1 
ATOM   3891 O O    . LEU A 1 287 ? 10.040  -21.340 14.659  1.00 18.05  ? 251 LEU A O    1 
ATOM   3892 C CB   . LEU A 1 287 ? 9.275   -24.643 14.301  1.00 18.51  ? 251 LEU A CB   1 
ATOM   3893 C CG   . LEU A 1 287 ? 8.608   -24.377 15.642  1.00 24.98  ? 251 LEU A CG   1 
ATOM   3894 C CD1  . LEU A 1 287 ? 7.327   -23.553 15.434  1.00 18.66  ? 251 LEU A CD1  1 
ATOM   3895 C CD2  . LEU A 1 287 ? 8.290   -25.672 16.360  1.00 20.83  ? 251 LEU A CD2  1 
ATOM   3896 H H    . LEU A 1 287 ? 10.620  -24.647 12.279  1.00 22.07  ? 251 LEU A H    1 
ATOM   3897 H HA   . LEU A 1 287 ? 8.866   -22.951 13.231  1.00 21.18  ? 251 LEU A HA   1 
ATOM   3898 H HB2  . LEU A 1 287 ? 8.651   -25.159 13.768  1.00 22.20  ? 251 LEU A HB2  1 
ATOM   3899 H HB3  . LEU A 1 287 ? 10.073  -25.166 14.477  1.00 22.20  ? 251 LEU A HB3  1 
ATOM   3900 H HG   . LEU A 1 287 ? 9.218   -23.873 16.202  1.00 29.97  ? 251 LEU A HG   1 
ATOM   3901 H HD11 . LEU A 1 287 ? 6.768   -23.635 16.223  1.00 22.38  ? 251 LEU A HD11 1 
ATOM   3902 H HD12 . LEU A 1 287 ? 7.568   -22.624 15.295  1.00 22.38  ? 251 LEU A HD12 1 
ATOM   3903 H HD13 . LEU A 1 287 ? 6.855   -23.893 14.658  1.00 22.38  ? 251 LEU A HD13 1 
ATOM   3904 H HD21 . LEU A 1 287 ? 7.986   -25.469 17.259  1.00 24.98  ? 251 LEU A HD21 1 
ATOM   3905 H HD22 . LEU A 1 287 ? 7.594   -26.141 15.874  1.00 24.98  ? 251 LEU A HD22 1 
ATOM   3906 H HD23 . LEU A 1 287 ? 9.092   -26.218 16.397  1.00 24.98  ? 251 LEU A HD23 1 
ATOM   3907 N N    . ARG A 1 288 ? 11.769  -22.746 14.591  1.00 23.11  ? 252 ARG A N    1 
ATOM   3908 C CA   . ARG A 1 288 ? 12.567  -21.811 15.372  1.00 21.57  ? 252 ARG A CA   1 
ATOM   3909 C C    . ARG A 1 288 ? 12.617  -20.447 14.688  1.00 18.30  ? 252 ARG A C    1 
ATOM   3910 O O    . ARG A 1 288 ? 12.492  -19.411 15.343  1.00 22.16  ? 252 ARG A O    1 
ATOM   3911 C CB   . ARG A 1 288 ? 13.968  -22.404 15.594  1.00 22.06  ? 252 ARG A CB   1 
ATOM   3912 C CG   . ARG A 1 288 ? 14.946  -21.497 16.311  1.00 33.48  ? 252 ARG A CG   1 
ATOM   3913 C CD   . ARG A 1 288 ? 16.276  -22.245 16.664  1.00 34.96  ? 252 ARG A CD   1 
ATOM   3914 N NE   . ARG A 1 288 ? 16.977  -22.754 15.489  1.00 38.20  ? 252 ARG A NE   1 
ATOM   3915 C CZ   . ARG A 1 288 ? 17.890  -22.092 14.787  1.00 45.23  ? 252 ARG A CZ   1 
ATOM   3916 N NH1  . ARG A 1 288 ? 18.248  -20.856 15.100  1.00 44.76  ? 252 ARG A NH1  1 
ATOM   3917 N NH2  . ARG A 1 288 ? 18.469  -22.694 13.748  1.00 43.60  ? 252 ARG A NH2  1 
ATOM   3918 H H    . ARG A 1 288 ? 12.168  -23.468 14.346  1.00 27.72  ? 252 ARG A H    1 
ATOM   3919 H HA   . ARG A 1 288 ? 12.171  -21.675 16.246  1.00 25.88  ? 252 ARG A HA   1 
ATOM   3920 H HB2  . ARG A 1 288 ? 13.878  -23.211 16.125  1.00 26.46  ? 252 ARG A HB2  1 
ATOM   3921 H HB3  . ARG A 1 288 ? 14.351  -22.617 14.729  1.00 26.46  ? 252 ARG A HB3  1 
ATOM   3922 H HG2  . ARG A 1 288 ? 15.163  -20.744 15.739  1.00 40.16  ? 252 ARG A HG2  1 
ATOM   3923 H HG3  . ARG A 1 288 ? 14.546  -21.182 17.136  1.00 40.16  ? 252 ARG A HG3  1 
ATOM   3924 H HD2  . ARG A 1 288 ? 16.870  -21.632 17.124  1.00 41.95  ? 252 ARG A HD2  1 
ATOM   3925 H HD3  . ARG A 1 288 ? 16.070  -23.000 17.238  1.00 41.95  ? 252 ARG A HD3  1 
ATOM   3926 H HE   . ARG A 1 288 ? 16.783  -23.550 15.229  1.00 45.83  ? 252 ARG A HE   1 
ATOM   3927 H HH11 . ARG A 1 288 ? 17.887  -20.461 15.773  1.00 53.70  ? 252 ARG A HH11 1 
ATOM   3928 H HH12 . ARG A 1 288 ? 18.842  -20.448 14.630  1.00 53.70  ? 252 ARG A HH12 1 
ATOM   3929 H HH21 . ARG A 1 288 ? 18.250  -23.499 13.541  1.00 52.31  ? 252 ARG A HH21 1 
ATOM   3930 H HH22 . ARG A 1 288 ? 19.061  -22.277 13.285  1.00 52.31  ? 252 ARG A HH22 1 
ATOM   3931 N N    . ILE A 1 289 ? 12.793  -20.422 13.362  1.00 18.51  ? 253 ILE A N    1 
ATOM   3932 C CA   . ILE A 1 289 ? 12.883  -19.143 12.661  1.00 18.43  ? 253 ILE A CA   1 
ATOM   3933 C C    . ILE A 1 289 ? 11.580  -18.380 12.828  1.00 19.50  ? 253 ILE A C    1 
ATOM   3934 O O    . ILE A 1 289 ? 11.563  -17.182 13.143  1.00 17.58  ? 253 ILE A O    1 
ATOM   3935 C CB   . ILE A 1 289 ? 13.230  -19.412 11.181  1.00 18.56  ? 253 ILE A CB   1 
ATOM   3936 C CG1  . ILE A 1 289 ? 14.711  -19.818 11.067  1.00 21.67  ? 253 ILE A CG1  1 
ATOM   3937 C CG2  . ILE A 1 289 ? 12.926  -18.229 10.260  1.00 19.25  ? 253 ILE A CG2  1 
ATOM   3938 C CD1  . ILE A 1 289 ? 15.051  -20.377 9.677   1.00 21.47  ? 253 ILE A CD1  1 
ATOM   3939 H H    . ILE A 1 289 ? 12.861  -21.116 12.859  1.00 22.20  ? 253 ILE A H    1 
ATOM   3940 H HA   . ILE A 1 289 ? 13.589  -18.595 13.040  1.00 22.10  ? 253 ILE A HA   1 
ATOM   3941 H HB   . ILE A 1 289 ? 12.659  -20.138 10.884  1.00 22.26  ? 253 ILE A HB   1 
ATOM   3942 H HG12 . ILE A 1 289 ? 15.268  -19.040 11.226  1.00 25.99  ? 253 ILE A HG12 1 
ATOM   3943 H HG13 . ILE A 1 289 ? 14.905  -20.504 11.725  1.00 25.99  ? 253 ILE A HG13 1 
ATOM   3944 H HG21 . ILE A 1 289 ? 13.114  -18.486 9.344   1.00 23.09  ? 253 ILE A HG21 1 
ATOM   3945 H HG22 . ILE A 1 289 ? 11.990  -17.991 10.352  1.00 23.09  ? 253 ILE A HG22 1 
ATOM   3946 H HG23 . ILE A 1 289 ? 13.485  -17.479 10.515  1.00 23.09  ? 253 ILE A HG23 1 
ATOM   3947 H HD11 . ILE A 1 289 ? 15.932  -20.784 9.707   1.00 25.76  ? 253 ILE A HD11 1 
ATOM   3948 H HD12 . ILE A 1 289 ? 14.388  -21.042 9.433   1.00 25.76  ? 253 ILE A HD12 1 
ATOM   3949 H HD13 . ILE A 1 289 ? 15.044  -19.651 9.034   1.00 25.76  ? 253 ILE A HD13 1 
ATOM   3950 N N    . ALA A 1 290 ? 10.460  -19.085 12.686  1.00 17.67  ? 254 ALA A N    1 
ATOM   3951 C CA   . ALA A 1 290 ? 9.172   -18.416 12.767  1.00 16.72  ? 254 ALA A CA   1 
ATOM   3952 C C    . ALA A 1 290 ? 8.916   -17.923 14.179  1.00 14.71  ? 254 ALA A C    1 
ATOM   3953 O O    . ALA A 1 290 ? 8.346   -16.851 14.367  1.00 17.56  ? 254 ALA A O    1 
ATOM   3954 C CB   . ALA A 1 290 ? 8.062   -19.369 12.311  1.00 20.13  ? 254 ALA A CB   1 
ATOM   3955 H H    . ALA A 1 290 ? 10.421  -19.933 12.546  1.00 21.20  ? 254 ALA A H    1 
ATOM   3956 H HA   . ALA A 1 290 ? 9.166   -17.650 12.172  1.00 20.05  ? 254 ALA A HA   1 
ATOM   3957 H HB1  . ALA A 1 290 ? 7.202   -18.943 12.452  1.00 24.15  ? 254 ALA A HB1  1 
ATOM   3958 H HB2  . ALA A 1 290 ? 8.182   -19.567 11.369  1.00 24.15  ? 254 ALA A HB2  1 
ATOM   3959 H HB3  . ALA A 1 290 ? 8.115   -20.187 12.830  1.00 24.15  ? 254 ALA A HB3  1 
ATOM   3960 N N    . GLN A 1 291 ? 9.311   -18.699 15.176  1.00 18.58  ? 255 GLN A N    1 
ATOM   3961 C CA   . GLN A 1 291 ? 9.155   -18.265 16.561  1.00 19.28  ? 255 GLN A CA   1 
ATOM   3962 C C    . GLN A 1 291 ? 9.985   -17.025 16.832  1.00 21.82  ? 255 GLN A C    1 
ATOM   3963 O O    . GLN A 1 291 ? 9.652   -16.245 17.722  1.00 24.44  ? 255 GLN A O    1 
ATOM   3964 C CB   . GLN A 1 291 ? 9.566   -19.384 17.518  1.00 21.61  ? 255 GLN A CB   1 
ATOM   3965 C CG   . GLN A 1 291 ? 8.682   -20.611 17.459  1.00 19.15  ? 255 GLN A CG   1 
ATOM   3966 C CD   . GLN A 1 291 ? 9.243   -21.824 18.221  1.00 24.06  ? 255 GLN A CD   1 
ATOM   3967 O OE1  . GLN A 1 291 ? 10.444  -22.062 18.254  1.00 26.34  ? 255 GLN A OE1  1 
ATOM   3968 N NE2  . GLN A 1 291 ? 8.350   -22.601 18.811  1.00 28.81  ? 255 GLN A NE2  1 
ATOM   3969 H H    . GLN A 1 291 ? 9.671   -19.474 15.083  1.00 22.29  ? 255 GLN A H    1 
ATOM   3970 H HA   . GLN A 1 291 ? 8.221   -18.061 16.724  1.00 23.13  ? 255 GLN A HA   1 
ATOM   3971 H HB2  . GLN A 1 291 ? 10.469  -19.661 17.300  1.00 25.92  ? 255 GLN A HB2  1 
ATOM   3972 H HB3  . GLN A 1 291 ? 9.534   -19.042 18.425  1.00 25.92  ? 255 GLN A HB3  1 
ATOM   3973 H HG2  . GLN A 1 291 ? 7.820   -20.393 17.847  1.00 22.97  ? 255 GLN A HG2  1 
ATOM   3974 H HG3  . GLN A 1 291 ? 8.573   -20.872 16.531  1.00 22.97  ? 255 GLN A HG3  1 
ATOM   3975 H HE21 . GLN A 1 291 ? 7.513   -22.414 18.755  1.00 34.56  ? 255 GLN A HE21 1 
ATOM   3976 H HE22 . GLN A 1 291 ? 8.607   -23.294 19.252  1.00 34.56  ? 255 GLN A HE22 1 
ATOM   3977 N N    . ALA A 1 292 ? 11.068  -16.841 16.090  1.00 17.52  ? 256 ALA A N    1 
ATOM   3978 C CA   . ALA A 1 292 ? 11.858  -15.619 16.224  1.00 24.13  ? 256 ALA A CA   1 
ATOM   3979 C C    . ALA A 1 292 ? 11.259  -14.444 15.465  1.00 24.36  ? 256 ALA A C    1 
ATOM   3980 O O    . ALA A 1 292 ? 11.836  -13.345 15.489  1.00 21.73  ? 256 ALA A O    1 
ATOM   3981 C CB   . ALA A 1 292 ? 13.294  -15.877 15.753  1.00 20.37  ? 256 ALA A CB   1 
ATOM   3982 H H    . ALA A 1 292 ? 11.365  -17.401 15.509  1.00 21.01  ? 256 ALA A H    1 
ATOM   3983 H HA   . ALA A 1 292 ? 11.897  -15.367 17.160  1.00 28.95  ? 256 ALA A HA   1 
ATOM   3984 H HB1  . ALA A 1 292 ? 13.814  -15.067 15.866  1.00 24.43  ? 256 ALA A HB1  1 
ATOM   3985 H HB2  . ALA A 1 292 ? 13.676  -16.593 16.284  1.00 24.43  ? 256 ALA A HB2  1 
ATOM   3986 H HB3  . ALA A 1 292 ? 13.278  -16.132 14.817  1.00 24.43  ? 256 ALA A HB3  1 
ATOM   3987 N N    . GLY A 1 293 ? 10.104  -14.623 14.819  1.00 20.43  ? 257 GLY A N    1 
ATOM   3988 C CA   . GLY A 1 293 ? 9.512   -13.560 14.030  1.00 19.24  ? 257 GLY A CA   1 
ATOM   3989 C C    . GLY A 1 293 ? 10.174  -13.355 12.684  1.00 16.22  ? 257 GLY A C    1 
ATOM   3990 O O    . GLY A 1 293 ? 9.952   -12.318 12.041  1.00 17.30  ? 257 GLY A O    1 
ATOM   3991 H H    . GLY A 1 293 ? 9.650   -15.354 14.826  1.00 24.51  ? 257 GLY A H    1 
ATOM   3992 H HA2  . GLY A 1 293 ? 8.577   -13.766 13.876  1.00 23.08  ? 257 GLY A HA2  1 
ATOM   3993 H HA3  . GLY A 1 293 ? 9.575   -12.729 14.526  1.00 23.08  ? 257 GLY A HA3  1 
ATOM   3994 N N    . LYS A 1 294 ? 11.036  -14.274 12.286  1.00 17.84  ? 258 LYS A N    1 
ATOM   3995 C CA   . LYS A 1 294 ? 11.785  -14.172 11.048  1.00 17.29  ? 258 LYS A CA   1 
ATOM   3996 C C    . LYS A 1 294 ? 11.154  -15.031 9.979   1.00 18.76  ? 258 LYS A C    1 
ATOM   3997 O O    . LYS A 1 294 ? 10.295  -15.885 10.254  1.00 15.85  ? 258 LYS A O    1 
ATOM   3998 C CB   . LYS A 1 294 ? 13.225  -14.602 11.278  1.00 18.50  ? 258 LYS A CB   1 
ATOM   3999 C CG   . LYS A 1 294 ? 13.928  -13.741 12.288  1.00 24.86  ? 258 LYS A CG   1 
ATOM   4000 C CD   . LYS A 1 294 ? 15.323  -14.273 12.526  1.00 23.53  ? 258 LYS A CD   1 
ATOM   4001 C CE   . LYS A 1 294 ? 16.018  -13.547 13.674  1.00 24.77  ? 258 LYS A CE   1 
ATOM   4002 N NZ   . LYS A 1 294 ? 16.011  -12.067 13.557  1.00 25.31  ? 258 LYS A NZ   1 
ATOM   4003 H H    . LYS A 1 294 ? 11.209  -14.989 12.730  1.00 21.39  ? 258 LYS A H    1 
ATOM   4004 H HA   . LYS A 1 294 ? 11.778  -13.251 10.743  1.00 20.73  ? 258 LYS A HA   1 
ATOM   4005 H HB2  . LYS A 1 294 ? 13.235  -15.516 11.603  1.00 22.19  ? 258 LYS A HB2  1 
ATOM   4006 H HB3  . LYS A 1 294 ? 13.711  -14.543 10.441  1.00 22.19  ? 258 LYS A HB3  1 
ATOM   4007 H HG2  . LYS A 1 294 ? 13.993  -12.832 11.956  1.00 29.82  ? 258 LYS A HG2  1 
ATOM   4008 H HG3  . LYS A 1 294 ? 13.441  -13.754 13.127  1.00 29.82  ? 258 LYS A HG3  1 
ATOM   4009 H HD2  . LYS A 1 294 ? 15.273  -15.216 12.750  1.00 28.23  ? 258 LYS A HD2  1 
ATOM   4010 H HD3  . LYS A 1 294 ? 15.854  -14.151 11.724  1.00 28.23  ? 258 LYS A HD3  1 
ATOM   4011 H HE2  . LYS A 1 294 ? 15.569  -13.777 14.503  1.00 29.71  ? 258 LYS A HE2  1 
ATOM   4012 H HE3  . LYS A 1 294 ? 16.944  -13.834 13.707  1.00 29.71  ? 258 LYS A HE3  1 
ATOM   4013 H HZ1  . LYS A 1 294 ? 16.826  -11.745 13.713  1.00 30.36  ? 258 LYS A HZ1  1 
ATOM   4014 H HZ2  . LYS A 1 294 ? 15.758  -11.827 12.738  1.00 30.36  ? 258 LYS A HZ2  1 
ATOM   4015 H HZ3  . LYS A 1 294 ? 15.445  -11.717 14.148  1.00 30.36  ? 258 LYS A HZ3  1 
ATOM   4016 N N    . MET A 1 295 ? 11.595  -14.792 8.745   1.00 17.68  ? 259 MET A N    1 
ATOM   4017 C CA   . MET A 1 295 ? 11.105  -15.555 7.611   1.00 20.83  ? 259 MET A CA   1 
ATOM   4018 C C    . MET A 1 295 ? 12.113  -16.580 7.123   1.00 19.16  ? 259 MET A C    1 
ATOM   4019 O O    . MET A 1 295 ? 13.319  -16.480 7.362   1.00 17.46  ? 259 MET A O    1 
ATOM   4020 C CB   . MET A 1 295 ? 10.642  -14.667 6.448   1.00 21.43  ? 259 MET A CB   1 
ATOM   4021 C CG   . MET A 1 295 ? 10.112  -13.228 6.781   1.00 18.78  ? 259 MET A CG   1 
ATOM   4022 S SD   . MET A 1 295 ? 9.845   -12.270 5.315   1.00 20.34  ? 259 MET A SD   1 
ATOM   4023 C CE   . MET A 1 295 ? 11.336  -11.165 5.388   1.00 16.50  ? 259 MET A CE   1 
ATOM   4024 H H    . MET A 1 295 ? 12.177  -14.192 8.545   1.00 21.21  ? 259 MET A H    1 
ATOM   4025 H HA   . MET A 1 295 ? 10.322  -16.035 7.925   1.00 24.99  ? 259 MET A HA   1 
ATOM   4026 H HB2  . MET A 1 295 ? 11.395  -14.552 5.847   1.00 25.71  ? 259 MET A HB2  1 
ATOM   4027 H HB3  . MET A 1 295 ? 9.922   -15.129 5.992   1.00 25.71  ? 259 MET A HB3  1 
ATOM   4028 H HG2  . MET A 1 295 ? 9.268   -13.300 7.255   1.00 22.53  ? 259 MET A HG2  1 
ATOM   4029 H HG3  . MET A 1 295 ? 10.763  -12.767 7.332   1.00 22.53  ? 259 MET A HG3  1 
ATOM   4030 H HE1  . MET A 1 295 ? 11.372  -10.629 4.581   1.00 19.79  ? 259 MET A HE1  1 
ATOM   4031 H HE2  . MET A 1 295 ? 11.264  -10.588 6.165   1.00 19.79  ? 259 MET A HE2  1 
ATOM   4032 H HE3  . MET A 1 295 ? 12.133  -11.714 5.457   1.00 19.79  ? 259 MET A HE3  1 
ATOM   4033 N N    . SER A 1 296 ? 11.584  -17.627 6.497   1.00 19.14  ? 260 SER A N    1 
ATOM   4034 C CA   . SER A 1 296 ? 12.407  -18.669 5.918   1.00 15.78  ? 260 SER A CA   1 
ATOM   4035 C C    . SER A 1 296 ? 12.063  -18.799 4.436   1.00 15.36  ? 260 SER A C    1 
ATOM   4036 O O    . SER A 1 296 ? 10.920  -18.606 4.013   1.00 17.48  ? 260 SER A O    1 
ATOM   4037 C CB   . SER A 1 296 ? 12.230  -20.008 6.669   1.00 18.50  ? 260 SER A CB   1 
ATOM   4038 O OG   . SER A 1 296 ? 10.988  -20.530 6.407   1.00 26.43  ? 260 SER A OG   1 
ATOM   4039 H H    . SER A 1 296 ? 10.739  -17.751 6.396   1.00 22.96  ? 260 SER A H    1 
ATOM   4040 H HA   . SER A 1 296 ? 13.348  -18.443 5.983   1.00 18.92  ? 260 SER A HA   1 
ATOM   4041 H HB2  . SER A 1 296 ? 12.909  -20.633 6.371   1.00 22.19  ? 260 SER A HB2  1 
ATOM   4042 H HB3  . SER A 1 296 ? 12.317  -19.853 7.622   1.00 22.19  ? 260 SER A HB3  1 
ATOM   4043 H HG   . SER A 1 296 ? 10.392  -20.005 6.680   1.00 31.70  ? 260 SER A HG   1 
ATOM   4044 N N    . ILE A 1 297 ? 13.073  -19.128 3.643   1.00 16.45  ? 261 ILE A N    1 
ATOM   4045 C CA   . ILE A 1 297 ? 12.871  -19.518 2.259   1.00 16.21  ? 261 ILE A CA   1 
ATOM   4046 C C    . ILE A 1 297 ? 13.302  -20.975 2.160   1.00 14.31  ? 261 ILE A C    1 
ATOM   4047 O O    . ILE A 1 297 ? 14.428  -21.301 2.496   1.00 16.58  ? 261 ILE A O    1 
ATOM   4048 C CB   . ILE A 1 297 ? 13.657  -18.638 1.295   1.00 19.71  ? 261 ILE A CB   1 
ATOM   4049 C CG1  . ILE A 1 297 ? 13.077  -17.202 1.262   1.00 19.96  ? 261 ILE A CG1  1 
ATOM   4050 C CG2  . ILE A 1 297 ? 13.492  -19.164 -0.093  1.00 19.46  ? 261 ILE A CG2  1 
ATOM   4051 C CD1  . ILE A 1 297 ? 13.168  -16.420 2.524   1.00 31.26  ? 261 ILE A CD1  1 
ATOM   4052 H H    . ILE A 1 297 ? 13.897  -19.131 3.889   1.00 19.73  ? 261 ILE A H    1 
ATOM   4053 H HA   . ILE A 1 297 ? 11.934  -19.440 2.020   1.00 19.44  ? 261 ILE A HA   1 
ATOM   4054 H HB   . ILE A 1 297 ? 14.581  -18.636 1.591   1.00 23.64  ? 261 ILE A HB   1 
ATOM   4055 H HG12 . ILE A 1 297 ? 13.552  -16.701 0.581   1.00 23.95  ? 261 ILE A HG12 1 
ATOM   4056 H HG13 . ILE A 1 297 ? 12.136  -17.263 1.032   1.00 23.95  ? 261 ILE A HG13 1 
ATOM   4057 H HG21 . ILE A 1 297 ? 13.950  -18.573 -0.711  1.00 23.34  ? 261 ILE A HG21 1 
ATOM   4058 H HG22 . ILE A 1 297 ? 13.874  -20.054 -0.141  1.00 23.34  ? 261 ILE A HG22 1 
ATOM   4059 H HG23 . ILE A 1 297 ? 12.546  -19.197 -0.307  1.00 23.34  ? 261 ILE A HG23 1 
ATOM   4060 H HD11 . ILE A 1 297 ? 12.859  -15.515 2.358   1.00 37.50  ? 261 ILE A HD11 1 
ATOM   4061 H HD12 . ILE A 1 297 ? 12.612  -16.841 3.198   1.00 37.50  ? 261 ILE A HD12 1 
ATOM   4062 H HD13 . ILE A 1 297 ? 14.092  -16.405 2.820   1.00 37.50  ? 261 ILE A HD13 1 
ATOM   4063 N N    . PHE A 1 298 ? 12.393  -21.847 1.764   1.00 16.52  ? 262 PHE A N    1 
ATOM   4064 C CA   . PHE A 1 298 ? 12.705  -23.270 1.599   1.00 17.21  ? 262 PHE A CA   1 
ATOM   4065 C C    . PHE A 1 298 ? 12.941  -23.498 0.108   1.00 16.44  ? 262 PHE A C    1 
ATOM   4066 O O    . PHE A 1 298 ? 11.992  -23.617 -0.666  1.00 18.36  ? 262 PHE A O    1 
ATOM   4067 C CB   . PHE A 1 298 ? 11.552  -24.101 2.139   1.00 17.27  ? 262 PHE A CB   1 
ATOM   4068 C CG   . PHE A 1 298 ? 11.818  -25.587 2.192   1.00 15.97  ? 262 PHE A CG   1 
ATOM   4069 C CD1  . PHE A 1 298 ? 11.690  -26.346 1.061   1.00 17.32  ? 262 PHE A CD1  1 
ATOM   4070 C CD2  . PHE A 1 298 ? 12.124  -26.197 3.389   1.00 18.40  ? 262 PHE A CD2  1 
ATOM   4071 C CE1  . PHE A 1 298 ? 11.892  -27.756 1.126   1.00 17.42  ? 262 PHE A CE1  1 
ATOM   4072 C CE2  . PHE A 1 298 ? 12.320  -27.580 3.452   1.00 18.86  ? 262 PHE A CE2  1 
ATOM   4073 C CZ   . PHE A 1 298 ? 12.223  -28.321 2.330   1.00 16.38  ? 262 PHE A CZ   1 
ATOM   4074 H H    . PHE A 1 298 ? 11.578  -21.644 1.580   1.00 19.82  ? 262 PHE A H    1 
ATOM   4075 H HA   . PHE A 1 298 ? 13.512  -23.517 2.077   1.00 20.64  ? 262 PHE A HA   1 
ATOM   4076 H HB2  . PHE A 1 298 ? 11.356  -23.807 3.043   1.00 20.71  ? 262 PHE A HB2  1 
ATOM   4077 H HB3  . PHE A 1 298 ? 10.779  -23.963 1.570   1.00 20.71  ? 262 PHE A HB3  1 
ATOM   4078 H HD1  . PHE A 1 298 ? 11.472  -25.943 0.251   1.00 20.77  ? 262 PHE A HD1  1 
ATOM   4079 H HD2  . PHE A 1 298 ? 12.202  -25.685 4.162   1.00 22.07  ? 262 PHE A HD2  1 
ATOM   4080 H HE1  . PHE A 1 298 ? 11.800  -28.283 0.365   1.00 20.90  ? 262 PHE A HE1  1 
ATOM   4081 H HE2  . PHE A 1 298 ? 12.516  -27.988 4.264   1.00 22.62  ? 262 PHE A HE2  1 
ATOM   4082 H HZ   . PHE A 1 298 ? 12.384  -29.236 2.373   1.00 19.64  ? 262 PHE A HZ   1 
ATOM   4083 N N    . ARG A 1 299 ? 14.198  -23.534 -0.294  1.00 15.68  ? 263 ARG A N    1 
ATOM   4084 C CA   . ARG A 1 299 ? 14.537  -23.532 -1.711  1.00 18.71  ? 263 ARG A CA   1 
ATOM   4085 C C    . ARG A 1 299 ? 14.979  -24.913 -2.165  1.00 18.93  ? 263 ARG A C    1 
ATOM   4086 O O    . ARG A 1 299 ? 15.757  -25.589 -1.487  1.00 21.10  ? 263 ARG A O    1 
ATOM   4087 C CB   . ARG A 1 299 ? 15.646  -22.525 -2.027  1.00 22.06  ? 263 ARG A CB   1 
ATOM   4088 C CG   . ARG A 1 299 ? 16.016  -22.546 -3.501  1.00 21.37  ? 263 ARG A CG   1 
ATOM   4089 C CD   . ARG A 1 299 ? 17.272  -23.408 -3.688  1.00 22.04  ? 263 ARG A CD   1 
ATOM   4090 N NE   . ARG A 1 299 ? 17.528  -23.594 -5.106  1.00 23.33  ? 263 ARG A NE   1 
ATOM   4091 C CZ   . ARG A 1 299 ? 18.527  -24.307 -5.615  1.00 28.29  ? 263 ARG A CZ   1 
ATOM   4092 N NH1  . ARG A 1 299 ? 19.378  -24.964 -4.839  1.00 21.89  ? 263 ARG A NH1  1 
ATOM   4093 N NH2  . ARG A 1 299 ? 18.670  -24.359 -6.941  1.00 25.48  ? 263 ARG A NH2  1 
ATOM   4094 H H    . ARG A 1 299 ? 14.877  -23.559 0.234   1.00 18.81  ? 263 ARG A H    1 
ATOM   4095 H HA   . ARG A 1 299 ? 13.742  -23.287 -2.209  1.00 22.44  ? 263 ARG A HA   1 
ATOM   4096 H HB2  . ARG A 1 299 ? 15.342  -21.632 -1.801  1.00 26.46  ? 263 ARG A HB2  1 
ATOM   4097 H HB3  . ARG A 1 299 ? 16.437  -22.746 -1.511  1.00 26.46  ? 263 ARG A HB3  1 
ATOM   4098 H HG2  . ARG A 1 299 ? 15.291  -22.929 -4.019  1.00 25.63  ? 263 ARG A HG2  1 
ATOM   4099 H HG3  . ARG A 1 299 ? 16.204  -21.645 -3.809  1.00 25.63  ? 263 ARG A HG3  1 
ATOM   4100 H HD2  . ARG A 1 299 ? 18.037  -22.966 -3.288  1.00 26.44  ? 263 ARG A HD2  1 
ATOM   4101 H HD3  . ARG A 1 299 ? 17.138  -24.277 -3.278  1.00 26.44  ? 263 ARG A HD3  1 
ATOM   4102 H HE   . ARG A 1 299 ? 16.991  -23.213 -5.659  1.00 27.98  ? 263 ARG A HE   1 
ATOM   4103 H HH11 . ARG A 1 299 ? 19.290  -24.934 -3.984  1.00 26.25  ? 263 ARG A HH11 1 
ATOM   4104 H HH12 . ARG A 1 299 ? 20.017  -25.419 -5.191  1.00 26.25  ? 263 ARG A HH12 1 
ATOM   4105 H HH21 . ARG A 1 299 ? 18.121  -23.935 -7.450  1.00 30.57  ? 263 ARG A HH21 1 
ATOM   4106 H HH22 . ARG A 1 299 ? 19.311  -24.816 -7.287  1.00 30.57  ? 263 ARG A HH22 1 
ATOM   4107 N N    . ILE A 1 300 ? 14.464  -25.309 -3.320  1.00 25.41  ? 264 ILE A N    1 
ATOM   4108 C CA   . ILE A 1 300 ? 14.764  -26.592 -3.917  1.00 22.08  ? 264 ILE A CA   1 
ATOM   4109 C C    . ILE A 1 300 ? 15.271  -26.375 -5.328  1.00 27.13  ? 264 ILE A C    1 
ATOM   4110 O O    . ILE A 1 300 ? 14.607  -25.724 -6.141  1.00 23.16  ? 264 ILE A O    1 
ATOM   4111 C CB   . ILE A 1 300 ? 13.533  -27.516 -3.934  1.00 21.23  ? 264 ILE A CB   1 
ATOM   4112 C CG1  . ILE A 1 300 ? 13.163  -27.915 -2.512  1.00 23.13  ? 264 ILE A CG1  1 
ATOM   4113 C CG2  . ILE A 1 300 ? 13.832  -28.692 -4.865  1.00 24.64  ? 264 ILE A CG2  1 
ATOM   4114 C CD1  . ILE A 1 300 ? 14.197  -28.774 -1.852  1.00 22.40  ? 264 ILE A CD1  1 
ATOM   4115 H H    . ILE A 1 300 ? 13.922  -24.833 -3.788  1.00 30.49  ? 264 ILE A H    1 
ATOM   4116 H HA   . ILE A 1 300 ? 15.469  -27.016 -3.403  1.00 26.48  ? 264 ILE A HA   1 
ATOM   4117 H HB   . ILE A 1 300 ? 12.750  -27.064 -4.285  1.00 25.47  ? 264 ILE A HB   1 
ATOM   4118 H HG12 . ILE A 1 300 ? 13.058  -27.112 -1.978  1.00 27.74  ? 264 ILE A HG12 1 
ATOM   4119 H HG13 . ILE A 1 300 ? 12.330  -28.412 -2.532  1.00 27.74  ? 264 ILE A HG13 1 
ATOM   4120 H HG21 . ILE A 1 300 ? 13.267  -29.441 -4.620  1.00 29.55  ? 264 ILE A HG21 1 
ATOM   4121 H HG22 . ILE A 1 300 ? 13.650  -28.425 -5.780  1.00 29.55  ? 264 ILE A HG22 1 
ATOM   4122 H HG23 . ILE A 1 300 ? 14.766  -28.939 -4.772  1.00 29.55  ? 264 ILE A HG23 1 
ATOM   4123 H HD11 . ILE A 1 300 ? 13.894  -29.003 -0.959  1.00 26.86  ? 264 ILE A HD11 1 
ATOM   4124 H HD12 . ILE A 1 300 ? 14.318  -29.581 -2.377  1.00 26.86  ? 264 ILE A HD12 1 
ATOM   4125 H HD13 . ILE A 1 300 ? 15.031  -28.283 -1.803  1.00 26.86  ? 264 ILE A HD13 1 
ATOM   4126 N N    . GLY A 1 301 ? 16.443  -26.922 -5.609  1.00 26.08  ? 265 GLY A N    1 
ATOM   4127 C CA   . GLY A 1 301 ? 16.923  -27.057 -6.963  1.00 30.60  ? 265 GLY A CA   1 
ATOM   4128 C C    . GLY A 1 301 ? 16.995  -28.538 -7.272  1.00 36.98  ? 265 GLY A C    1 
ATOM   4129 O O    . GLY A 1 301 ? 17.751  -29.272 -6.623  1.00 33.26  ? 265 GLY A O    1 
ATOM   4130 H H    . GLY A 1 301 ? 16.987  -27.228 -5.018  1.00 31.29  ? 265 GLY A H    1 
ATOM   4131 H HA2  . GLY A 1 301 ? 16.317  -26.623 -7.584  1.00 36.71  ? 265 GLY A HA2  1 
ATOM   4132 H HA3  . GLY A 1 301 ? 17.804  -26.661 -7.053  1.00 36.71  ? 265 GLY A HA3  1 
ATOM   4133 N N    . VAL A 1 302 ? 16.203  -29.000 -8.239  1.00 34.13  ? 266 VAL A N    1 
ATOM   4134 C CA   . VAL A 1 302 ? 16.151  -30.429 -8.521  1.00 43.54  ? 266 VAL A CA   1 
ATOM   4135 C C    . VAL A 1 302 ? 17.442  -30.874 -9.197  1.00 44.95  ? 266 VAL A C    1 
ATOM   4136 O O    . VAL A 1 302 ? 17.613  -32.065 -9.479  1.00 43.26  ? 266 VAL A O    1 
ATOM   4137 C CB   . VAL A 1 302 ? 14.923  -30.816 -9.364  1.00 42.61  ? 266 VAL A CB   1 
ATOM   4138 C CG1  . VAL A 1 302 ? 13.689  -30.139 -8.818  1.00 46.48  ? 266 VAL A CG1  1 
ATOM   4139 C CG2  . VAL A 1 302 ? 15.118  -30.476 -10.835 1.00 52.20  ? 266 VAL A CG2  1 
ATOM   4140 H H    . VAL A 1 302 ? 15.696  -28.513 -8.735  1.00 40.95  ? 266 VAL A H    1 
ATOM   4141 H HA   . VAL A 1 302 ? 16.081  -30.892 -7.671  1.00 52.24  ? 266 VAL A HA   1 
ATOM   4142 H HB   . VAL A 1 302 ? 14.805  -31.777 -9.309  1.00 51.12  ? 266 VAL A HB   1 
ATOM   4143 H HG11 . VAL A 1 302 ? 12.923  -30.399 -9.353  1.00 55.76  ? 266 VAL A HG11 1 
ATOM   4144 H HG12 . VAL A 1 302 ? 13.559  -30.414 -7.898  1.00 55.76  ? 266 VAL A HG12 1 
ATOM   4145 H HG13 . VAL A 1 302 ? 13.811  -29.177 -8.862  1.00 55.76  ? 266 VAL A HG13 1 
ATOM   4146 H HG21 . VAL A 1 302 ? 14.319  -30.723 -11.325 1.00 62.63  ? 266 VAL A HG21 1 
ATOM   4147 H HG22 . VAL A 1 302 ? 15.277  -29.522 -10.920 1.00 62.63  ? 266 VAL A HG22 1 
ATOM   4148 H HG23 . VAL A 1 302 ? 15.881  -30.969 -11.175 1.00 62.63  ? 266 VAL A HG23 1 
ATOM   4149 N N    . GLU A 1 303 ? 18.367  -29.936 -9.444  1.00 36.22  ? 267 GLU A N    1 
ATOM   4150 C CA   . GLU A 1 303 ? 19.709  -30.347 -9.851  1.00 43.86  ? 267 GLU A CA   1 
ATOM   4151 C C    . GLU A 1 303 ? 20.361  -31.220 -8.788  1.00 44.46  ? 267 GLU A C    1 
ATOM   4152 O O    . GLU A 1 303 ? 21.295  -31.963 -9.100  1.00 42.32  ? 267 GLU A O    1 
ATOM   4153 C CB   . GLU A 1 303 ? 20.615  -29.139 -10.139 1.00 38.03  ? 267 GLU A CB   1 
ATOM   4154 C CG   . GLU A 1 303 ? 21.024  -28.317 -8.923  1.00 45.49  ? 267 GLU A CG   1 
ATOM   4155 C CD   . GLU A 1 303 ? 20.090  -27.167 -8.664  1.00 42.57  ? 267 GLU A CD   1 
ATOM   4156 O OE1  . GLU A 1 303 ? 18.893  -27.326 -8.963  1.00 31.47  ? 267 GLU A OE1  1 
ATOM   4157 O OE2  . GLU A 1 303 ? 20.553  -26.121 -8.154  1.00 33.21  ? 267 GLU A OE2  1 
ATOM   4158 H H    . GLU A 1 303 ? 18.244  -29.087 -9.385  1.00 43.46  ? 267 GLU A H    1 
ATOM   4159 H HA   . GLU A 1 303 ? 19.630  -30.844 -10.680 1.00 52.62  ? 267 GLU A HA   1 
ATOM   4160 H HB2  . GLU A 1 303 ? 21.430  -29.462 -10.556 1.00 45.63  ? 267 GLU A HB2  1 
ATOM   4161 H HB3  . GLU A 1 303 ? 20.147  -28.544 -10.745 1.00 45.63  ? 267 GLU A HB3  1 
ATOM   4162 H HG2  . GLU A 1 303 ? 21.022  -28.889 -8.139  1.00 54.57  ? 267 GLU A HG2  1 
ATOM   4163 H HG3  . GLU A 1 303 ? 21.913  -27.956 -9.069  1.00 54.57  ? 267 GLU A HG3  1 
ATOM   4164 N N    . SER A 1 304 ? 19.906  -31.124 -7.536  1.00 43.39  ? 268 SER A N    1 
ATOM   4165 C CA   . SER A 1 304 ? 20.415  -31.937 -6.438  1.00 48.28  ? 268 SER A CA   1 
ATOM   4166 C C    . SER A 1 304 ? 19.548  -33.165 -6.166  1.00 51.18  ? 268 SER A C    1 
ATOM   4167 O O    . SER A 1 304 ? 19.769  -33.867 -5.173  1.00 48.27  ? 268 SER A O    1 
ATOM   4168 C CB   . SER A 1 304 ? 20.528  -31.085 -5.169  1.00 46.89  ? 268 SER A CB   1 
ATOM   4169 O OG   . SER A 1 304 ? 21.670  -30.243 -5.221  1.00 48.23  ? 268 SER A OG   1 
ATOM   4170 H H    . SER A 1 304 ? 19.285  -30.579 -7.295  1.00 52.06  ? 268 SER A H    1 
ATOM   4171 H HA   . SER A 1 304 ? 21.303  -32.251 -6.669  1.00 57.93  ? 268 SER A HA   1 
ATOM   4172 H HB2  . SER A 1 304 ? 19.733  -30.534 -5.088  1.00 56.25  ? 268 SER A HB2  1 
ATOM   4173 H HB3  . SER A 1 304 ? 20.603  -31.672 -4.401  1.00 56.25  ? 268 SER A HB3  1 
ATOM   4174 H HG   . SER A 1 304 ? 21.766  -29.844 -4.488  1.00 57.87  ? 268 SER A HG   1 
ATOM   4175 N N    . ASP A 1 305 ? 18.564  -33.431 -7.019  1.00 45.21  ? 269 ASP A N    1 
ATOM   4176 C CA   . ASP A 1 305 ? 17.724  -34.608 -6.857  1.00 56.23  ? 269 ASP A CA   1 
ATOM   4177 C C    . ASP A 1 305 ? 18.516  -35.864 -7.226  1.00 60.44  ? 269 ASP A C    1 
ATOM   4178 O O    . ASP A 1 305 ? 19.394  -35.816 -8.092  1.00 62.19  ? 269 ASP A O    1 
ATOM   4179 C CB   . ASP A 1 305 ? 16.477  -34.483 -7.737  1.00 57.61  ? 269 ASP A CB   1 
ATOM   4180 C CG   . ASP A 1 305 ? 15.475  -35.608 -7.514  1.00 56.22  ? 269 ASP A CG   1 
ATOM   4181 O OD1  . ASP A 1 305 ? 15.634  -36.674 -8.140  1.00 53.61  ? 269 ASP A OD1  1 
ATOM   4182 O OD2  . ASP A 1 305 ? 14.513  -35.419 -6.738  1.00 48.40  ? 269 ASP A OD2  1 
ATOM   4183 H H    . ASP A 1 305 ? 18.363  -32.945 -7.700  1.00 54.24  ? 269 ASP A H    1 
ATOM   4184 H HA   . ASP A 1 305 ? 17.433  -34.695 -5.936  1.00 67.46  ? 269 ASP A HA   1 
ATOM   4185 H HB2  . ASP A 1 305 ? 16.033  -33.644 -7.537  1.00 69.12  ? 269 ASP A HB2  1 
ATOM   4186 H HB3  . ASP A 1 305 ? 16.746  -34.503 -8.669  1.00 69.12  ? 269 ASP A HB3  1 
ATOM   4187 N N    . PRO A 1 306 ? 18.246  -36.999 -6.565  1.00 64.42  ? 270 PRO A N    1 
ATOM   4188 C CA   . PRO A 1 306 ? 18.939  -38.247 -6.957  1.00 62.16  ? 270 PRO A CA   1 
ATOM   4189 C C    . PRO A 1 306 ? 18.833  -38.573 -8.444  1.00 63.73  ? 270 PRO A C    1 
ATOM   4190 O O    . PRO A 1 306 ? 19.851  -38.872 -9.084  1.00 66.01  ? 270 PRO A O    1 
ATOM   4191 C CB   . PRO A 1 306 ? 18.261  -39.325 -6.088  1.00 56.13  ? 270 PRO A CB   1 
ATOM   4192 C CG   . PRO A 1 306 ? 17.285  -38.611 -5.185  1.00 59.94  ? 270 PRO A CG   1 
ATOM   4193 C CD   . PRO A 1 306 ? 17.529  -37.140 -5.286  1.00 63.68  ? 270 PRO A CD   1 
ATOM   4194 H HA   . PRO A 1 306 ? 19.874  -38.172 -6.708  1.00 74.58  ? 270 PRO A HA   1 
ATOM   4195 H HB2  . PRO A 1 306 ? 17.797  -39.955 -6.661  1.00 67.35  ? 270 PRO A HB2  1 
ATOM   4196 H HB3  . PRO A 1 306 ? 18.934  -39.787 -5.564  1.00 67.35  ? 270 PRO A HB3  1 
ATOM   4197 H HG2  . PRO A 1 306 ? 16.381  -38.819 -5.470  1.00 71.92  ? 270 PRO A HG2  1 
ATOM   4198 H HG3  . PRO A 1 306 ? 17.422  -38.909 -4.273  1.00 71.92  ? 270 PRO A HG3  1 
ATOM   4199 H HD2  . PRO A 1 306 ? 16.690  -36.652 -5.306  1.00 76.40  ? 270 PRO A HD2  1 
ATOM   4200 H HD3  . PRO A 1 306 ? 18.076  -36.830 -4.548  1.00 76.40  ? 270 PRO A HD3  1 
ATOM   4201 N N    . ARG A 1 307 ? 17.627  -38.523 -9.011  1.00 63.01  ? 271 ARG A N    1 
ATOM   4202 C CA   . ARG A 1 307 ? 17.401  -38.879 -10.416 1.00 60.60  ? 271 ARG A CA   1 
ATOM   4203 C C    . ARG A 1 307 ? 18.317  -38.095 -11.365 1.00 62.95  ? 271 ARG A C    1 
ATOM   4204 O O    . ARG A 1 307 ? 18.226  -36.871 -11.487 1.00 58.95  ? 271 ARG A O    1 
ATOM   4205 C CB   . ARG A 1 307 ? 15.924  -38.645 -10.796 1.00 62.05  ? 271 ARG A CB   1 
ATOM   4206 C CG   . ARG A 1 307 ? 14.924  -39.661 -10.185 1.00 71.27  ? 271 ARG A CG   1 
ATOM   4207 C CD   . ARG A 1 307 ? 13.635  -38.989 -9.658  1.00 73.33  ? 271 ARG A CD   1 
ATOM   4208 N NE   . ARG A 1 307 ? 12.909  -39.783 -8.663  1.00 70.44  ? 271 ARG A NE   1 
ATOM   4209 C CZ   . ARG A 1 307 ? 13.320  -40.006 -7.420  1.00 63.48  ? 271 ARG A CZ   1 
ATOM   4210 N NH1  . ARG A 1 307 ? 14.485  -39.552 -6.983  1.00 61.67  ? 271 ARG A NH1  1 
ATOM   4211 N NH2  . ARG A 1 307 ? 12.544  -40.704 -6.593  1.00 64.59  ? 271 ARG A NH2  1 
ATOM   4212 H H    . ARG A 1 307 ? 16.912  -38.284 -8.598  1.00 75.60  ? 271 ARG A H    1 
ATOM   4213 H HA   . ARG A 1 307 ? 17.606  -39.820 -10.529 1.00 72.72  ? 271 ARG A HA   1 
ATOM   4214 H HB2  . ARG A 1 307 ? 15.665  -37.762 -10.491 1.00 74.44  ? 271 ARG A HB2  1 
ATOM   4215 H HB3  . ARG A 1 307 ? 15.843  -38.700 -11.761 1.00 74.44  ? 271 ARG A HB3  1 
ATOM   4216 H HG2  . ARG A 1 307 ? 14.670  -40.304 -10.866 1.00 85.51  ? 271 ARG A HG2  1 
ATOM   4217 H HG3  . ARG A 1 307 ? 15.350  -40.117 -9.442  1.00 85.51  ? 271 ARG A HG3  1 
ATOM   4218 H HD2  . ARG A 1 307 ? 13.871  -38.144 -9.244  1.00 87.99  ? 271 ARG A HD2  1 
ATOM   4219 H HD3  . ARG A 1 307 ? 13.036  -38.836 -10.405 1.00 87.99  ? 271 ARG A HD3  1 
ATOM   4220 H HE   . ARG A 1 307 ? 12.159  -40.131 -8.903  1.00 84.51  ? 271 ARG A HE   1 
ATOM   4221 H HH11 . ARG A 1 307 ? 14.995  -39.101 -7.508  1.00 73.99  ? 271 ARG A HH11 1 
ATOM   4222 H HH12 . ARG A 1 307 ? 14.731  -39.708 -6.174  1.00 73.99  ? 271 ARG A HH12 1 
ATOM   4223 H HH21 . ARG A 1 307 ? 11.786  -41.005 -6.866  1.00 77.50  ? 271 ARG A HH21 1 
ATOM   4224 H HH22 . ARG A 1 307 ? 12.800  -40.854 -5.786  1.00 77.50  ? 271 ARG A HH22 1 
ATOM   4225 N N    . ASP A 1 320 ? 16.599  -34.297 -18.547 1.00 59.29  ? 284 ASP A N    1 
ATOM   4226 C CA   . ASP A 1 320 ? 16.000  -33.023 -18.940 1.00 60.67  ? 284 ASP A CA   1 
ATOM   4227 C C    . ASP A 1 320 ? 15.262  -32.429 -17.737 1.00 56.31  ? 284 ASP A C    1 
ATOM   4228 O O    . ASP A 1 320 ? 14.291  -33.011 -17.243 1.00 47.36  ? 284 ASP A O    1 
ATOM   4229 C CB   . ASP A 1 320 ? 15.063  -33.215 -20.127 1.00 55.24  ? 284 ASP A CB   1 
ATOM   4230 C CG   . ASP A 1 320 ? 14.837  -31.935 -20.899 1.00 64.46  ? 284 ASP A CG   1 
ATOM   4231 O OD1  . ASP A 1 320 ? 15.800  -31.444 -21.540 1.00 63.71  ? 284 ASP A OD1  1 
ATOM   4232 O OD2  . ASP A 1 320 ? 13.693  -31.429 -20.869 1.00 58.84  ? 284 ASP A OD2  1 
ATOM   4233 H HA   . ASP A 1 320 ? 16.682  -32.396 -19.226 1.00 72.79  ? 284 ASP A HA   1 
ATOM   4234 H HB2  . ASP A 1 320 ? 15.448  -33.868 -20.732 1.00 66.28  ? 284 ASP A HB2  1 
ATOM   4235 H HB3  . ASP A 1 320 ? 14.204  -33.528 -19.805 1.00 66.28  ? 284 ASP A HB3  1 
ATOM   4236 N N    . GLN A 1 321 ? 15.726  -31.259 -17.284 1.00 54.94  ? 285 GLN A N    1 
ATOM   4237 C CA   . GLN A 1 321 ? 15.381  -30.739 -15.965 1.00 51.21  ? 285 GLN A CA   1 
ATOM   4238 C C    . GLN A 1 321 ? 13.931  -30.284 -15.832 1.00 45.56  ? 285 GLN A C    1 
ATOM   4239 O O    . GLN A 1 321 ? 13.323  -30.524 -14.781 1.00 41.47  ? 285 GLN A O    1 
ATOM   4240 C CB   . GLN A 1 321 ? 16.311  -29.573 -15.598 1.00 52.24  ? 285 GLN A CB   1 
ATOM   4241 C CG   . GLN A 1 321 ? 17.794  -29.887 -15.748 1.00 62.32  ? 285 GLN A CG   1 
ATOM   4242 C CD   . GLN A 1 321 ? 18.321  -30.778 -14.634 1.00 73.48  ? 285 GLN A CD   1 
ATOM   4243 O OE1  . GLN A 1 321 ? 18.036  -30.559 -13.451 1.00 62.40  ? 285 GLN A OE1  1 
ATOM   4244 N NE2  . GLN A 1 321 ? 19.091  -31.797 -15.010 1.00 76.62  ? 285 GLN A NE2  1 
ATOM   4245 H H    . GLN A 1 321 ? 16.249  -30.743 -17.731 1.00 65.91  ? 285 GLN A H    1 
ATOM   4246 H HA   . GLN A 1 321 ? 15.487  -31.477 -15.345 1.00 61.44  ? 285 GLN A HA   1 
ATOM   4247 H HB2  . GLN A 1 321 ? 16.110  -28.821 -16.176 1.00 62.68  ? 285 GLN A HB2  1 
ATOM   4248 H HB3  . GLN A 1 321 ? 16.155  -29.331 -14.671 1.00 62.68  ? 285 GLN A HB3  1 
ATOM   4249 H HG2  . GLN A 1 321 ? 17.937  -30.345 -16.592 1.00 74.78  ? 285 GLN A HG2  1 
ATOM   4250 H HG3  . GLN A 1 321 ? 18.297  -29.058 -15.732 1.00 74.78  ? 285 GLN A HG3  1 
ATOM   4251 H HE21 . GLN A 1 321 ? 19.265  -31.920 -15.843 1.00 91.93  ? 285 GLN A HE21 1 
ATOM   4252 H HE22 . GLN A 1 321 ? 19.415  -32.332 -14.419 1.00 91.93  ? 285 GLN A HE22 1 
ATOM   4253 N N    . PRO A 1 322 ? 13.342  -29.618 -16.836 1.00 45.04  ? 286 PRO A N    1 
ATOM   4254 C CA   . PRO A 1 322 ? 11.935  -29.203 -16.682 1.00 45.99  ? 286 PRO A CA   1 
ATOM   4255 C C    . PRO A 1 322 ? 11.003  -30.377 -16.449 1.00 44.21  ? 286 PRO A C    1 
ATOM   4256 O O    . PRO A 1 322 ? 10.111  -30.306 -15.596 1.00 33.92  ? 286 PRO A O    1 
ATOM   4257 C CB   . PRO A 1 322 ? 11.632  -28.481 -18.007 1.00 47.38  ? 286 PRO A CB   1 
ATOM   4258 C CG   . PRO A 1 322 ? 12.961  -28.040 -18.508 1.00 50.55  ? 286 PRO A CG   1 
ATOM   4259 C CD   . PRO A 1 322 ? 13.901  -29.152 -18.120 1.00 51.51  ? 286 PRO A CD   1 
ATOM   4260 H HA   . PRO A 1 322 ? 11.852  -28.569 -15.952 1.00 55.18  ? 286 PRO A HA   1 
ATOM   4261 H HB2  . PRO A 1 322 ? 11.211  -29.094 -18.630 1.00 56.84  ? 286 PRO A HB2  1 
ATOM   4262 H HB3  . PRO A 1 322 ? 11.051  -27.721 -17.845 1.00 56.84  ? 286 PRO A HB3  1 
ATOM   4263 H HG2  . PRO A 1 322 ? 12.932  -27.929 -19.471 1.00 60.65  ? 286 PRO A HG2  1 
ATOM   4264 H HG3  . PRO A 1 322 ? 13.215  -27.205 -18.085 1.00 60.65  ? 286 PRO A HG3  1 
ATOM   4265 H HD2  . PRO A 1 322 ? 13.891  -29.862 -18.781 1.00 61.81  ? 286 PRO A HD2  1 
ATOM   4266 H HD3  . PRO A 1 322 ? 14.804  -28.818 -18.004 1.00 61.81  ? 286 PRO A HD3  1 
ATOM   4267 N N    . VAL A 1 323 ? 11.187  -31.461 -17.201 1.00 41.58  ? 287 VAL A N    1 
ATOM   4268 C CA   . VAL A 1 323 ? 10.358  -32.649 -17.015 1.00 43.41  ? 287 VAL A CA   1 
ATOM   4269 C C    . VAL A 1 323 ? 10.534  -33.200 -15.605 1.00 38.05  ? 287 VAL A C    1 
ATOM   4270 O O    . VAL A 1 323 ? 9.557   -33.448 -14.890 1.00 37.96  ? 287 VAL A O    1 
ATOM   4271 C CB   . VAL A 1 323 ? 10.697  -33.700 -18.088 1.00 44.36  ? 287 VAL A CB   1 
ATOM   4272 C CG1  . VAL A 1 323 ? 10.005  -35.029 -17.798 1.00 37.76  ? 287 VAL A CG1  1 
ATOM   4273 C CG2  . VAL A 1 323 ? 10.304  -33.169 -19.455 1.00 41.86  ? 287 VAL A CG2  1 
ATOM   4274 H H    . VAL A 1 323 ? 11.778  -31.534 -17.821 1.00 49.89  ? 287 VAL A H    1 
ATOM   4275 H HA   . VAL A 1 323 ? 9.426   -32.402 -17.118 1.00 52.09  ? 287 VAL A HA   1 
ATOM   4276 H HB   . VAL A 1 323 ? 11.652  -33.869 -18.080 1.00 53.22  ? 287 VAL A HB   1 
ATOM   4277 H HG11 . VAL A 1 323 ? 10.071  -35.597 -18.581 1.00 45.30  ? 287 VAL A HG11 1 
ATOM   4278 H HG12 . VAL A 1 323 ? 10.442  -35.454 -17.043 1.00 45.30  ? 287 VAL A HG12 1 
ATOM   4279 H HG13 . VAL A 1 323 ? 9.073   -34.861 -17.589 1.00 45.30  ? 287 VAL A HG13 1 
ATOM   4280 H HG21 . VAL A 1 323 ? 10.482  -33.851 -20.122 1.00 50.22  ? 287 VAL A HG21 1 
ATOM   4281 H HG22 . VAL A 1 323 ? 9.358   -32.951 -19.450 1.00 50.22  ? 287 VAL A HG22 1 
ATOM   4282 H HG23 . VAL A 1 323 ? 10.825  -32.374 -19.647 1.00 50.22  ? 287 VAL A HG23 1 
ATOM   4283 N N    . LEU A 1 324 ? 11.786  -33.390 -15.182 1.00 39.45  ? 288 LEU A N    1 
ATOM   4284 C CA   . LEU A 1 324 ? 12.064  -33.867 -13.831 1.00 39.73  ? 288 LEU A CA   1 
ATOM   4285 C C    . LEU A 1 324 ? 11.477  -32.930 -12.784 1.00 40.27  ? 288 LEU A C    1 
ATOM   4286 O O    . LEU A 1 324 ? 10.783  -33.362 -11.850 1.00 32.01  ? 288 LEU A O    1 
ATOM   4287 C CB   . LEU A 1 324 ? 13.571  -33.989 -13.630 1.00 36.79  ? 288 LEU A CB   1 
ATOM   4288 C CG   . LEU A 1 324 ? 14.031  -34.413 -12.232 1.00 39.91  ? 288 LEU A CG   1 
ATOM   4289 C CD1  . LEU A 1 324 ? 13.313  -35.672 -11.770 1.00 48.55  ? 288 LEU A CD1  1 
ATOM   4290 C CD2  . LEU A 1 324 ? 15.536  -34.605 -12.213 1.00 45.18  ? 288 LEU A CD2  1 
ATOM   4291 H H    . LEU A 1 324 ? 12.488  -33.250 -15.657 1.00 47.33  ? 288 LEU A H    1 
ATOM   4292 H HA   . LEU A 1 324 ? 11.659  -34.742 -13.721 1.00 47.66  ? 288 LEU A HA   1 
ATOM   4293 H HB2  . LEU A 1 324 ? 13.908  -34.650 -14.256 1.00 44.14  ? 288 LEU A HB2  1 
ATOM   4294 H HB3  . LEU A 1 324 ? 13.972  -33.125 -13.814 1.00 44.14  ? 288 LEU A HB3  1 
ATOM   4295 H HG   . LEU A 1 324 ? 13.804  -33.712 -11.601 1.00 47.88  ? 288 LEU A HG   1 
ATOM   4296 H HD11 . LEU A 1 324 ? 13.647  -35.923 -10.894 1.00 58.25  ? 288 LEU A HD11 1 
ATOM   4297 H HD12 . LEU A 1 324 ? 12.361  -35.494 -11.723 1.00 58.25  ? 288 LEU A HD12 1 
ATOM   4298 H HD13 . LEU A 1 324 ? 13.485  -36.385 -12.405 1.00 58.25  ? 288 LEU A HD13 1 
ATOM   4299 H HD21 . LEU A 1 324 ? 15.811  -34.857 -11.318 1.00 54.21  ? 288 LEU A HD21 1 
ATOM   4300 H HD22 . LEU A 1 324 ? 15.772  -35.306 -12.841 1.00 54.21  ? 288 LEU A HD22 1 
ATOM   4301 H HD23 . LEU A 1 324 ? 15.963  -33.773 -12.469 1.00 54.21  ? 288 LEU A HD23 1 
ATOM   4302 N N    . ALA A 1 325 ? 11.760  -31.635 -12.920 1.00 35.10  ? 289 ALA A N    1 
ATOM   4303 C CA   . ALA A 1 325 ? 11.263  -30.671 -11.948 1.00 35.36  ? 289 ALA A CA   1 
ATOM   4304 C C    . ALA A 1 325 ? 9.752   -30.770 -11.814 1.00 35.10  ? 289 ALA A C    1 
ATOM   4305 O O    . ALA A 1 325 ? 9.221   -30.825 -10.699 1.00 31.03  ? 289 ALA A O    1 
ATOM   4306 C CB   . ALA A 1 325 ? 11.689  -29.256 -12.345 1.00 39.30  ? 289 ALA A CB   1 
ATOM   4307 H H    . ALA A 1 325 ? 12.229  -31.297 -13.556 1.00 42.11  ? 289 ALA A H    1 
ATOM   4308 H HA   . ALA A 1 325 ? 11.655  -30.862 -11.081 1.00 42.42  ? 289 ALA A HA   1 
ATOM   4309 H HB1  . ALA A 1 325 ? 11.355  -28.629 -11.686 1.00 47.15  ? 289 ALA A HB1  1 
ATOM   4310 H HB2  . ALA A 1 325 ? 12.658  -29.216 -12.378 1.00 47.15  ? 289 ALA A HB2  1 
ATOM   4311 H HB3  . ALA A 1 325 ? 11.320  -29.048 -13.217 1.00 47.15  ? 289 ALA A HB3  1 
ATOM   4312 N N    . LYS A 1 326 ? 9.039   -30.822 -12.942 1.00 35.20  ? 290 LYS A N    1 
ATOM   4313 C CA   . LYS A 1 326 ? 7.581   -30.901 -12.878 1.00 36.81  ? 290 LYS A CA   1 
ATOM   4314 C C    . LYS A 1 326 ? 7.121   -32.196 -12.215 1.00 33.55  ? 290 LYS A C    1 
ATOM   4315 O O    . LYS A 1 326 ? 6.127   -32.203 -11.481 1.00 31.02  ? 290 LYS A O    1 
ATOM   4316 C CB   . LYS A 1 326 ? 6.992   -30.777 -14.279 1.00 40.08  ? 290 LYS A CB   1 
ATOM   4317 C CG   . LYS A 1 326 ? 7.143   -29.390 -14.894 1.00 42.33  ? 290 LYS A CG   1 
ATOM   4318 C CD   . LYS A 1 326 ? 6.240   -29.255 -16.111 1.00 48.32  ? 290 LYS A CD   1 
ATOM   4319 C CE   . LYS A 1 326 ? 6.591   -28.032 -16.926 1.00 50.84  ? 290 LYS A CE   1 
ATOM   4320 N NZ   . LYS A 1 326 ? 7.421   -27.096 -16.149 1.00 49.34  ? 290 LYS A NZ   1 
ATOM   4321 H H    . LYS A 1 326 ? 9.368   -30.814 -13.737 1.00 42.23  ? 290 LYS A H    1 
ATOM   4322 H HA   . LYS A 1 326 ? 7.253   -30.161 -12.344 1.00 44.16  ? 290 LYS A HA   1 
ATOM   4323 H HB2  . LYS A 1 326 ? 7.440   -31.409 -14.863 1.00 48.09  ? 290 LYS A HB2  1 
ATOM   4324 H HB3  . LYS A 1 326 ? 6.044   -30.980 -14.237 1.00 48.09  ? 290 LYS A HB3  1 
ATOM   4325 H HG2  . LYS A 1 326 ? 6.891   -28.716 -14.244 1.00 50.78  ? 290 LYS A HG2  1 
ATOM   4326 H HG3  . LYS A 1 326 ? 8.062   -29.255 -15.173 1.00 50.78  ? 290 LYS A HG3  1 
ATOM   4327 H HD2  . LYS A 1 326 ? 6.342   -30.038 -16.676 1.00 57.98  ? 290 LYS A HD2  1 
ATOM   4328 H HD3  . LYS A 1 326 ? 5.318   -29.174 -15.820 1.00 57.98  ? 290 LYS A HD3  1 
ATOM   4329 H HE2  . LYS A 1 326 ? 7.089   -28.302 -17.714 1.00 60.99  ? 290 LYS A HE2  1 
ATOM   4330 H HE3  . LYS A 1 326 ? 5.777   -27.574 -17.189 1.00 60.99  ? 290 LYS A HE3  1 
ATOM   4331 H HZ1  . LYS A 1 326 ? 7.502   -26.326 -16.587 1.00 59.19  ? 290 LYS A HZ1  1 
ATOM   4332 H HZ2  . LYS A 1 326 ? 7.045   -26.940 -15.358 1.00 59.19  ? 290 LYS A HZ2  1 
ATOM   4333 H HZ3  . LYS A 1 326 ? 8.231   -27.442 -16.021 1.00 59.19  ? 290 LYS A HZ3  1 
ATOM   4334 N N    . GLU A 1 327 ? 7.842   -33.298 -12.448 1.00 30.01  ? 291 GLU A N    1 
ATOM   4335 C CA   . GLU A 1 327 ? 7.451   -34.574 -11.854 1.00 34.90  ? 291 GLU A CA   1 
ATOM   4336 C C    . GLU A 1 327 ? 7.712   -34.597 -10.353 1.00 33.48  ? 291 GLU A C    1 
ATOM   4337 O O    . GLU A 1 327 ? 6.962   -35.225 -9.600  1.00 34.63  ? 291 GLU A O    1 
ATOM   4338 C CB   . GLU A 1 327 ? 8.190   -35.726 -12.543 1.00 36.89  ? 291 GLU A CB   1 
ATOM   4339 C CG   . GLU A 1 327 ? 7.671   -36.037 -13.959 1.00 42.27  ? 291 GLU A CG   1 
ATOM   4340 C CD   . GLU A 1 327 ? 8.602   -36.926 -14.795 1.00 46.46  ? 291 GLU A CD   1 
ATOM   4341 O OE2  . GLU A 1 327 ? 9.567   -37.500 -14.249 1.00 47.14  ? 291 GLU A OE2  1 
ATOM   4342 H H    . GLU A 1 327 ? 8.549   -33.331 -12.937 1.00 36.00  ? 291 GLU A H    1 
ATOM   4343 H HA   . GLU A 1 327 ? 6.499   -34.698 -11.993 1.00 41.87  ? 291 GLU A HA   1 
ATOM   4344 H HB2  . GLU A 1 327 ? 9.129   -35.494 -12.616 1.00 44.26  ? 291 GLU A HB2  1 
ATOM   4345 H HB3  . GLU A 1 327 ? 8.086   -36.528 -12.007 1.00 44.26  ? 291 GLU A HB3  1 
ATOM   4346 H HG2  . GLU A 1 327 ? 6.819   -36.494 -13.883 1.00 50.71  ? 291 GLU A HG2  1 
ATOM   4347 H HG3  . GLU A 1 327 ? 7.557   -35.201 -14.438 1.00 50.71  ? 291 GLU A HG3  1 
ATOM   4348 N N    . ARG A 1 328 ? 8.787   -33.953 -9.905  1.00 31.87  ? 292 ARG A N    1 
ATOM   4349 C CA   . ARG A 1 328 ? 9.161   -33.956 -8.496  1.00 33.56  ? 292 ARG A CA   1 
ATOM   4350 C C    . ARG A 1 328 ? 8.514   -32.823 -7.714  1.00 28.67  ? 292 ARG A C    1 
ATOM   4351 O O    . ARG A 1 328 ? 8.674   -32.765 -6.493  1.00 28.56  ? 292 ARG A O    1 
ATOM   4352 C CB   . ARG A 1 328 ? 10.682  -33.860 -8.337  1.00 34.57  ? 292 ARG A CB   1 
ATOM   4353 C CG   . ARG A 1 328 ? 11.459  -35.031 -8.929  1.00 41.56  ? 292 ARG A CG   1 
ATOM   4354 C CD   . ARG A 1 328 ? 11.177  -36.309 -8.184  1.00 44.49  ? 292 ARG A CD   1 
ATOM   4355 N NE   . ARG A 1 328 ? 11.926  -36.378 -6.937  1.00 38.93  ? 292 ARG A NE   1 
ATOM   4356 C CZ   . ARG A 1 328 ? 11.580  -37.127 -5.901  1.00 43.51  ? 292 ARG A CZ   1 
ATOM   4357 N NH1  . ARG A 1 328 ? 10.468  -37.848 -5.909  1.00 44.27  ? 292 ARG A NH1  1 
ATOM   4358 N NH2  . ARG A 1 328 ? 12.361  -37.148 -4.827  1.00 43.20  ? 292 ARG A NH2  1 
ATOM   4359 H H    . ARG A 1 328 ? 9.321   -33.501 -10.405 1.00 38.23  ? 292 ARG A H    1 
ATOM   4360 H HA   . ARG A 1 328 ? 8.874   -34.800 -8.114  1.00 40.27  ? 292 ARG A HA   1 
ATOM   4361 H HB2  . ARG A 1 328 ? 10.988  -33.053 -8.780  1.00 41.47  ? 292 ARG A HB2  1 
ATOM   4362 H HB3  . ARG A 1 328 ? 10.890  -33.819 -7.391  1.00 41.47  ? 292 ARG A HB3  1 
ATOM   4363 H HG2  . ARG A 1 328 ? 11.199  -35.154 -9.855  1.00 49.87  ? 292 ARG A HG2  1 
ATOM   4364 H HG3  . ARG A 1 328 ? 12.410  -34.847 -8.872  1.00 49.87  ? 292 ARG A HG3  1 
ATOM   4365 H HD2  . ARG A 1 328 ? 10.231  -36.356 -7.974  1.00 53.38  ? 292 ARG A HD2  1 
ATOM   4366 H HD3  . ARG A 1 328 ? 11.433  -37.065 -8.735  1.00 53.38  ? 292 ARG A HD3  1 
ATOM   4367 H HE   . ARG A 1 328 ? 12.639  -35.902 -6.869  1.00 46.71  ? 292 ARG A HE   1 
ATOM   4368 H HH11 . ARG A 1 328 ? 9.953   -37.836 -6.597  1.00 53.12  ? 292 ARG A HH11 1 
ATOM   4369 H HH12 . ARG A 1 328 ? 10.262  -38.328 -5.226  1.00 53.12  ? 292 ARG A HH12 1 
ATOM   4370 H HH21 . ARG A 1 328 ? 13.081  -36.678 -4.810  1.00 51.83  ? 292 ARG A HH21 1 
ATOM   4371 H HH22 . ARG A 1 328 ? 12.147  -37.630 -4.148  1.00 51.83  ? 292 ARG A HH22 1 
ATOM   4372 N N    . ALA A 1 329 ? 7.750   -31.956 -8.380  1.00 28.85  ? 293 ALA A N    1 
ATOM   4373 C CA   . ALA A 1 329 ? 7.170   -30.813 -7.686  1.00 29.68  ? 293 ALA A CA   1 
ATOM   4374 C C    . ALA A 1 329 ? 6.320   -31.258 -6.506  1.00 31.20  ? 293 ALA A C    1 
ATOM   4375 O O    . ALA A 1 329 ? 6.387   -30.666 -5.423  1.00 27.34  ? 293 ALA A O    1 
ATOM   4376 C CB   . ALA A 1 329 ? 6.351   -29.980 -8.660  1.00 28.56  ? 293 ALA A CB   1 
ATOM   4377 H H    . ALA A 1 329 ? 7.557   -32.007 -9.216  1.00 34.61  ? 293 ALA A H    1 
ATOM   4378 H HA   . ALA A 1 329 ? 7.885   -30.255 -7.342  1.00 35.60  ? 293 ALA A HA   1 
ATOM   4379 H HB1  . ALA A 1 329 ? 5.974   -29.221 -8.188  1.00 34.27  ? 293 ALA A HB1  1 
ATOM   4380 H HB2  . ALA A 1 329 ? 6.928   -29.671 -9.375  1.00 34.27  ? 293 ALA A HB2  1 
ATOM   4381 H HB3  . ALA A 1 329 ? 5.639   -30.530 -9.025  1.00 34.27  ? 293 ALA A HB3  1 
ATOM   4382 N N    . GLU A 1 330 ? 5.509   -32.302 -6.687  1.00 30.25  ? 294 GLU A N    1 
ATOM   4383 C CA   . GLU A 1 330 ? 4.652   -32.736 -5.591  1.00 29.67  ? 294 GLU A CA   1 
ATOM   4384 C C    . GLU A 1 330 ? 5.474   -33.171 -4.383  1.00 28.34  ? 294 GLU A C    1 
ATOM   4385 O O    . GLU A 1 330 ? 5.128   -32.863 -3.238  1.00 25.72  ? 294 GLU A O    1 
ATOM   4386 C CB   . GLU A 1 330 ? 3.740   -33.866 -6.065  1.00 32.80  ? 294 GLU A CB   1 
ATOM   4387 C CG   . GLU A 1 330 ? 2.864   -34.393 -4.960  1.00 29.85  ? 294 GLU A CG   1 
ATOM   4388 C CD   . GLU A 1 330 ? 1.855   -35.396 -5.452  1.00 33.13  ? 294 GLU A CD   1 
ATOM   4389 O OE1  . GLU A 1 330 ? 2.255   -36.320 -6.197  1.00 33.73  ? 294 GLU A OE1  1 
ATOM   4390 O OE2  . GLU A 1 330 ? 0.671   -35.239 -5.102  1.00 32.42  ? 294 GLU A OE2  1 
ATOM   4391 H H    . GLU A 1 330 ? 5.441   -32.760 -7.412  1.00 36.29  ? 294 GLU A H    1 
ATOM   4392 H HA   . GLU A 1 330 ? 4.091   -31.994 -5.315  1.00 35.60  ? 294 GLU A HA   1 
ATOM   4393 H HB2  . GLU A 1 330 ? 3.166   -33.535 -6.774  1.00 39.35  ? 294 GLU A HB2  1 
ATOM   4394 H HB3  . GLU A 1 330 ? 4.285   -34.598 -6.394  1.00 39.35  ? 294 GLU A HB3  1 
ATOM   4395 H HG2  . GLU A 1 330 ? 3.420   -34.827 -4.295  1.00 35.81  ? 294 GLU A HG2  1 
ATOM   4396 H HG3  . GLU A 1 330 ? 2.382   -33.653 -4.558  1.00 35.81  ? 294 GLU A HG3  1 
ATOM   4397 N N    . TYR A 1 331 ? 6.587   -33.866 -4.608  1.00 25.64  ? 295 TYR A N    1 
ATOM   4398 C CA   . TYR A 1 331 ? 7.374   -34.332 -3.478  1.00 24.57  ? 295 TYR A CA   1 
ATOM   4399 C C    . TYR A 1 331 ? 8.035   -33.177 -2.738  1.00 28.38  ? 295 TYR A C    1 
ATOM   4400 O O    . TYR A 1 331 ? 8.061   -33.148 -1.498  1.00 23.22  ? 295 TYR A O    1 
ATOM   4401 C CB   . TYR A 1 331 ? 8.450   -35.307 -3.936  1.00 26.76  ? 295 TYR A CB   1 
ATOM   4402 C CG   . TYR A 1 331 ? 9.412   -35.651 -2.828  1.00 25.47  ? 295 TYR A CG   1 
ATOM   4403 C CD1  . TYR A 1 331 ? 9.058   -36.549 -1.814  1.00 24.90  ? 295 TYR A CD1  1 
ATOM   4404 C CD2  . TYR A 1 331 ? 10.673  -35.075 -2.773  1.00 26.26  ? 295 TYR A CD2  1 
ATOM   4405 C CE1  . TYR A 1 331 ? 9.931   -36.846 -0.789  1.00 23.16  ? 295 TYR A CE1  1 
ATOM   4406 C CE2  . TYR A 1 331 ? 11.554  -35.376 -1.759  1.00 29.14  ? 295 TYR A CE2  1 
ATOM   4407 C CZ   . TYR A 1 331 ? 11.187  -36.255 -0.769  1.00 29.97  ? 295 TYR A CZ   1 
ATOM   4408 O OH   . TYR A 1 331 ? 12.082  -36.529 0.244   1.00 25.64  ? 295 TYR A OH   1 
ATOM   4409 H H    . TYR A 1 331 ? 6.897   -34.074 -5.383  1.00 30.76  ? 295 TYR A H    1 
ATOM   4410 H HA   . TYR A 1 331 ? 6.768   -34.791 -2.874  1.00 29.47  ? 295 TYR A HA   1 
ATOM   4411 H HB2  . TYR A 1 331 ? 8.030   -36.127 -4.238  1.00 32.10  ? 295 TYR A HB2  1 
ATOM   4412 H HB3  . TYR A 1 331 ? 8.955   -34.907 -4.661  1.00 32.10  ? 295 TYR A HB3  1 
ATOM   4413 H HD1  . TYR A 1 331 ? 8.220   -36.952 -1.832  1.00 29.88  ? 295 TYR A HD1  1 
ATOM   4414 H HD2  . TYR A 1 331 ? 10.928  -34.473 -3.434  1.00 31.50  ? 295 TYR A HD2  1 
ATOM   4415 H HE1  . TYR A 1 331 ? 9.680   -37.437 -0.116  1.00 27.78  ? 295 TYR A HE1  1 
ATOM   4416 H HE2  . TYR A 1 331 ? 12.397  -34.985 -1.744  1.00 34.96  ? 295 TYR A HE2  1 
ATOM   4417 H HH   . TYR A 1 331 ? 11.735  -37.053 0.801   1.00 30.76  ? 295 TYR A HH   1 
ATOM   4418 N N    . TYR A 1 332 ? 8.640   -32.258 -3.477  1.00 25.73  ? 296 TYR A N    1 
ATOM   4419 C CA   . TYR A 1 332 ? 9.400   -31.199 -2.816  1.00 25.01  ? 296 TYR A CA   1 
ATOM   4420 C C    . TYR A 1 332 ? 8.477   -30.170 -2.197  1.00 20.99  ? 296 TYR A C    1 
ATOM   4421 O O    . TYR A 1 332 ? 8.777   -29.649 -1.115  1.00 23.97  ? 296 TYR A O    1 
ATOM   4422 C CB   . TYR A 1 332 ? 10.371  -30.555 -3.796  1.00 24.61  ? 296 TYR A CB   1 
ATOM   4423 C CG   . TYR A 1 332 ? 11.580  -31.428 -4.038  1.00 25.04  ? 296 TYR A CG   1 
ATOM   4424 C CD1  . TYR A 1 332 ? 12.397  -31.812 -2.989  1.00 28.73  ? 296 TYR A CD1  1 
ATOM   4425 C CD2  . TYR A 1 332 ? 11.881  -31.887 -5.307  1.00 27.99  ? 296 TYR A CD2  1 
ATOM   4426 C CE1  . TYR A 1 332 ? 13.501  -32.623 -3.193  1.00 23.48  ? 296 TYR A CE1  1 
ATOM   4427 C CE2  . TYR A 1 332 ? 12.972  -32.699 -5.526  1.00 31.49  ? 296 TYR A CE2  1 
ATOM   4428 C CZ   . TYR A 1 332 ? 13.777  -33.058 -4.466  1.00 28.41  ? 296 TYR A CZ   1 
ATOM   4429 O OH   . TYR A 1 332 ? 14.859  -33.857 -4.679  1.00 32.92  ? 296 TYR A OH   1 
ATOM   4430 H H    . TYR A 1 332 ? 8.628   -32.223 -4.337  1.00 30.86  ? 296 TYR A H    1 
ATOM   4431 H HA   . TYR A 1 332 ? 9.932   -31.586 -2.102  1.00 30.00  ? 296 TYR A HA   1 
ATOM   4432 H HB2  . TYR A 1 332 ? 9.923   -30.413 -4.644  1.00 29.53  ? 296 TYR A HB2  1 
ATOM   4433 H HB3  . TYR A 1 332 ? 10.675  -29.707 -3.435  1.00 29.53  ? 296 TYR A HB3  1 
ATOM   4434 H HD1  . TYR A 1 332 ? 12.201  -31.518 -2.129  1.00 34.47  ? 296 TYR A HD1  1 
ATOM   4435 H HD2  . TYR A 1 332 ? 11.339  -31.643 -6.022  1.00 33.58  ? 296 TYR A HD2  1 
ATOM   4436 H HE1  . TYR A 1 332 ? 14.046  -32.869 -2.480  1.00 28.16  ? 296 TYR A HE1  1 
ATOM   4437 H HE2  . TYR A 1 332 ? 13.164  -33.004 -6.383  1.00 37.78  ? 296 TYR A HE2  1 
ATOM   4438 H HH   . TYR A 1 332 ? 14.972  -33.974 -5.503  1.00 39.49  ? 296 TYR A HH   1 
ATOM   4439 N N    . LEU A 1 333 ? 7.344   -29.891 -2.846  1.00 22.67  ? 297 LEU A N    1 
ATOM   4440 C CA   . LEU A 1 333 ? 6.323   -29.070 -2.215  1.00 22.66  ? 297 LEU A CA   1 
ATOM   4441 C C    . LEU A 1 333 ? 5.875   -29.711 -0.909  1.00 28.36  ? 297 LEU A C    1 
ATOM   4442 O O    . LEU A 1 333 ? 5.757   -29.048 0.122   1.00 19.85  ? 297 LEU A O    1 
ATOM   4443 C CB   . LEU A 1 333 ? 5.134   -28.865 -3.155  1.00 20.45  ? 297 LEU A CB   1 
ATOM   4444 C CG   . LEU A 1 333 ? 4.019   -27.990 -2.591  1.00 23.88  ? 297 LEU A CG   1 
ATOM   4445 C CD1  . LEU A 1 333 ? 4.613   -26.632 -2.225  1.00 24.40  ? 297 LEU A CD1  1 
ATOM   4446 C CD2  . LEU A 1 333 ? 2.874   -27.874 -3.561  1.00 20.39  ? 297 LEU A CD2  1 
ATOM   4447 H H    . LEU A 1 333 ? 7.150   -30.162 -3.639  1.00 27.19  ? 297 LEU A H    1 
ATOM   4448 H HA   . LEU A 1 333 ? 6.693   -28.193 -2.027  1.00 27.18  ? 297 LEU A HA   1 
ATOM   4449 H HB2  . LEU A 1 333 ? 5.454   -28.444 -3.968  1.00 24.53  ? 297 LEU A HB2  1 
ATOM   4450 H HB3  . LEU A 1 333 ? 4.751   -29.733 -3.359  1.00 24.53  ? 297 LEU A HB3  1 
ATOM   4451 H HG   . LEU A 1 333 ? 3.641   -28.388 -1.791  1.00 28.65  ? 297 LEU A HG   1 
ATOM   4452 H HD11 . LEU A 1 333 ? 3.891   -26.003 -2.071  1.00 29.27  ? 297 LEU A HD11 1 
ATOM   4453 H HD12 . LEU A 1 333 ? 5.146   -26.727 -1.421  1.00 29.27  ? 297 LEU A HD12 1 
ATOM   4454 H HD13 . LEU A 1 333 ? 5.169   -26.324 -2.957  1.00 29.27  ? 297 LEU A HD13 1 
ATOM   4455 H HD21 . LEU A 1 333 ? 2.190   -27.304 -3.176  1.00 24.46  ? 297 LEU A HD21 1 
ATOM   4456 H HD22 . LEU A 1 333 ? 3.200   -27.486 -4.389  1.00 24.46  ? 297 LEU A HD22 1 
ATOM   4457 H HD23 . LEU A 1 333 ? 2.512   -28.758 -3.730  1.00 24.46  ? 297 LEU A HD23 1 
ATOM   4458 N N    . ALA A 1 334 ? 5.625   -31.018 -0.933  1.00 24.23  ? 298 ALA A N    1 
ATOM   4459 C CA   . ALA A 1 334 ? 5.227   -31.690 0.290   1.00 24.73  ? 298 ALA A CA   1 
ATOM   4460 C C    . ALA A 1 334 ? 6.263   -31.493 1.380   1.00 21.49  ? 298 ALA A C    1 
ATOM   4461 O O    . ALA A 1 334 ? 5.907   -31.278 2.541   1.00 18.97  ? 298 ALA A O    1 
ATOM   4462 C CB   . ALA A 1 334 ? 5.015   -33.180 0.019   1.00 21.74  ? 298 ALA A CB   1 
ATOM   4463 H H    . ALA A 1 334 ? 5.678   -31.522 -1.628  1.00 29.06  ? 298 ALA A H    1 
ATOM   4464 H HA   . ALA A 1 334 ? 4.387   -31.315 0.598   1.00 29.67  ? 298 ALA A HA   1 
ATOM   4465 H HB1  . ALA A 1 334 ? 4.703   -33.608 0.832   1.00 26.08  ? 298 ALA A HB1  1 
ATOM   4466 H HB2  . ALA A 1 334 ? 4.354   -33.282 -0.684  1.00 26.08  ? 298 ALA A HB2  1 
ATOM   4467 H HB3  . ALA A 1 334 ? 5.857   -33.573 -0.260  1.00 26.08  ? 298 ALA A HB3  1 
ATOM   4468 N N    . CYS A 1 335 ? 7.549   -31.619 1.041   1.00 20.61  ? 299 CYS A N    1 
ATOM   4469 C CA   . CYS A 1 335 ? 8.580   -31.426 2.038   1.00 20.42  ? 299 CYS A CA   1 
ATOM   4470 C C    . CYS A 1 335 ? 8.486   -30.043 2.645   1.00 18.71  ? 299 CYS A C    1 
ATOM   4471 O O    . CYS A 1 335 ? 8.650   -29.870 3.851   1.00 20.48  ? 299 CYS A O    1 
ATOM   4472 C CB   . CYS A 1 335 ? 9.954   -31.599 1.432   1.00 20.49  ? 299 CYS A CB   1 
ATOM   4473 S SG   . CYS A 1 335 ? 10.244  -33.377 1.092   1.00 22.53  ? 299 CYS A SG   1 
ATOM   4474 H H    . CYS A 1 335 ? 7.836   -31.813 0.254   1.00 24.72  ? 299 CYS A H    1 
ATOM   4475 H HA   . CYS A 1 335 ? 8.461   -32.098 2.728   1.00 24.49  ? 299 CYS A HA   1 
ATOM   4476 H HB2  . CYS A 1 335 ? 10.011  -31.105 0.599   1.00 24.57  ? 299 CYS A HB2  1 
ATOM   4477 H HB3  . CYS A 1 335 ? 10.630  -31.282 2.051   1.00 24.57  ? 299 CYS A HB3  1 
ATOM   4478 H HG   . CYS A 1 335 ? 11.363  -33.520 0.682   1.00 27.03  ? 299 CYS A HG   1 
ATOM   4479 N N    . TYR A 1 336 ? 8.218   -29.046 1.821   1.00 20.78  ? 300 TYR A N    1 
ATOM   4480 C CA   . TYR A 1 336 ? 8.076   -27.702 2.361   1.00 22.01  ? 300 TYR A CA   1 
ATOM   4481 C C    . TYR A 1 336 ? 6.833   -27.583 3.248   1.00 20.91  ? 300 TYR A C    1 
ATOM   4482 O O    . TYR A 1 336 ? 6.901   -27.075 4.375   1.00 17.24  ? 300 TYR A O    1 
ATOM   4483 C CB   . TYR A 1 336 ? 8.020   -26.691 1.217   1.00 19.99  ? 300 TYR A CB   1 
ATOM   4484 C CG   . TYR A 1 336 ? 7.393   -25.391 1.631   1.00 18.23  ? 300 TYR A CG   1 
ATOM   4485 C CD1  . TYR A 1 336 ? 8.053   -24.531 2.499   1.00 21.60  ? 300 TYR A CD1  1 
ATOM   4486 C CD2  . TYR A 1 336 ? 6.145   -25.043 1.184   1.00 19.52  ? 300 TYR A CD2  1 
ATOM   4487 C CE1  . TYR A 1 336 ? 7.473   -23.335 2.897   1.00 18.60  ? 300 TYR A CE1  1 
ATOM   4488 C CE2  . TYR A 1 336 ? 5.537   -23.843 1.582   1.00 22.45  ? 300 TYR A CE2  1 
ATOM   4489 C CZ   . TYR A 1 336 ? 6.207   -23.009 2.450   1.00 18.50  ? 300 TYR A CZ   1 
ATOM   4490 O OH   . TYR A 1 336 ? 5.596   -21.831 2.840   1.00 20.43  ? 300 TYR A OH   1 
ATOM   4491 H H    . TYR A 1 336 ? 8.116   -29.116 0.970   1.00 24.92  ? 300 TYR A H    1 
ATOM   4492 H HA   . TYR A 1 336 ? 8.851   -27.503 2.909   1.00 26.40  ? 300 TYR A HA   1 
ATOM   4493 H HB2  . TYR A 1 336 ? 8.923   -26.507 0.912   1.00 23.98  ? 300 TYR A HB2  1 
ATOM   4494 H HB3  . TYR A 1 336 ? 7.494   -27.062 0.491   1.00 23.98  ? 300 TYR A HB3  1 
ATOM   4495 H HD1  . TYR A 1 336 ? 8.896   -24.760 2.819   1.00 25.90  ? 300 TYR A HD1  1 
ATOM   4496 H HD2  . TYR A 1 336 ? 5.693   -25.613 0.605   1.00 23.41  ? 300 TYR A HD2  1 
ATOM   4497 H HE1  . TYR A 1 336 ? 7.933   -22.756 3.460   1.00 22.30  ? 300 TYR A HE1  1 
ATOM   4498 H HE2  . TYR A 1 336 ? 4.694   -23.613 1.265   1.00 26.93  ? 300 TYR A HE2  1 
ATOM   4499 H HH   . TYR A 1 336 ? 6.146   -21.342 3.243   1.00 24.50  ? 300 TYR A HH   1 
ATOM   4500 N N    . LEU A 1 337 ? 5.692   -28.067 2.757   1.00 16.69  ? 301 LEU A N    1 
ATOM   4501 C CA   . LEU A 1 337 ? 4.429   -27.890 3.465   1.00 17.21  ? 301 LEU A CA   1 
ATOM   4502 C C    . LEU A 1 337 ? 4.452   -28.547 4.831   1.00 19.89  ? 301 LEU A C    1 
ATOM   4503 O O    . LEU A 1 337 ? 3.827   -28.054 5.761   1.00 18.26  ? 301 LEU A O    1 
ATOM   4504 C CB   . LEU A 1 337 ? 3.287   -28.459 2.639   1.00 19.02  ? 301 LEU A CB   1 
ATOM   4505 C CG   . LEU A 1 337 ? 2.994   -27.696 1.338   1.00 18.06  ? 301 LEU A CG   1 
ATOM   4506 C CD1  . LEU A 1 337 ? 1.955   -28.439 0.548   1.00 20.91  ? 301 LEU A CD1  1 
ATOM   4507 C CD2  . LEU A 1 337 ? 2.526   -26.297 1.703   1.00 18.67  ? 301 LEU A CD2  1 
ATOM   4508 H H    . LEU A 1 337 ? 5.623   -28.500 2.017   1.00 20.01  ? 301 LEU A H    1 
ATOM   4509 H HA   . LEU A 1 337 ? 4.276   -26.940 3.589   1.00 20.64  ? 301 LEU A HA   1 
ATOM   4510 H HB2  . LEU A 1 337 ? 3.506   -29.373 2.399   1.00 22.81  ? 301 LEU A HB2  1 
ATOM   4511 H HB3  . LEU A 1 337 ? 2.480   -28.441 3.176   1.00 22.81  ? 301 LEU A HB3  1 
ATOM   4512 H HG   . LEU A 1 337 ? 3.784   -27.622 0.781   1.00 21.67  ? 301 LEU A HG   1 
ATOM   4513 H HD11 . LEU A 1 337 ? 1.753   -27.938 -0.258  1.00 25.09  ? 301 LEU A HD11 1 
ATOM   4514 H HD12 . LEU A 1 337 ? 2.301   -29.314 0.315   1.00 25.09  ? 301 LEU A HD12 1 
ATOM   4515 H HD13 . LEU A 1 337 ? 1.155   -28.533 1.089   1.00 25.09  ? 301 LEU A HD13 1 
ATOM   4516 H HD21 . LEU A 1 337 ? 2.135   -25.880 0.919   1.00 22.40  ? 301 LEU A HD21 1 
ATOM   4517 H HD22 . LEU A 1 337 ? 1.863   -26.360 2.409   1.00 22.40  ? 301 LEU A HD22 1 
ATOM   4518 H HD23 . LEU A 1 337 ? 3.287   -25.779 2.008   1.00 22.40  ? 301 LEU A HD23 1 
ATOM   4519 N N    . ILE A 1 338 ? 5.164   -29.669 4.982   1.00 17.02  ? 302 ILE A N    1 
ATOM   4520 C CA   . ILE A 1 338 ? 5.210   -30.293 6.301   1.00 18.25  ? 302 ILE A CA   1 
ATOM   4521 C C    . ILE A 1 338 ? 5.712   -29.309 7.336   1.00 16.91  ? 302 ILE A C    1 
ATOM   4522 O O    . ILE A 1 338 ? 5.260   -29.295 8.485   1.00 16.32  ? 302 ILE A O    1 
ATOM   4523 C CB   . ILE A 1 338 ? 6.100   -31.553 6.272   1.00 14.62  ? 302 ILE A CB   1 
ATOM   4524 C CG1  . ILE A 1 338 ? 5.413   -32.648 5.474   1.00 22.73  ? 302 ILE A CG1  1 
ATOM   4525 C CG2  . ILE A 1 338 ? 6.463   -31.933 7.658   1.00 17.15  ? 302 ILE A CG2  1 
ATOM   4526 C CD1  . ILE A 1 338 ? 4.138   -33.161 6.100   1.00 21.17  ? 302 ILE A CD1  1 
ATOM   4527 H H    . ILE A 1 338 ? 5.609   -30.068 4.364   1.00 20.41  ? 302 ILE A H    1 
ATOM   4528 H HA   . ILE A 1 338 ? 4.308   -30.559 6.537   1.00 21.89  ? 302 ILE A HA   1 
ATOM   4529 H HB   . ILE A 1 338 ? 6.937   -31.380 5.814   1.00 17.54  ? 302 ILE A HB   1 
ATOM   4530 H HG12 . ILE A 1 338 ? 5.190   -32.299 4.597   1.00 27.26  ? 302 ILE A HG12 1 
ATOM   4531 H HG13 . ILE A 1 338 ? 6.022   -33.398 5.388   1.00 27.26  ? 302 ILE A HG13 1 
ATOM   4532 H HG21 . ILE A 1 338 ? 6.819   -32.835 7.655   1.00 20.57  ? 302 ILE A HG21 1 
ATOM   4533 H HG22 . ILE A 1 338 ? 7.132   -31.314 7.989   1.00 20.57  ? 302 ILE A HG22 1 
ATOM   4534 H HG23 . ILE A 1 338 ? 5.670   -31.891 8.214   1.00 20.57  ? 302 ILE A HG23 1 
ATOM   4535 H HD11 . ILE A 1 338 ? 3.792   -33.890 5.561   1.00 25.39  ? 302 ILE A HD11 1 
ATOM   4536 H HD12 . ILE A 1 338 ? 4.331   -33.476 6.997   1.00 25.39  ? 302 ILE A HD12 1 
ATOM   4537 H HD13 . ILE A 1 338 ? 3.490   -32.440 6.135   1.00 25.39  ? 302 ILE A HD13 1 
ATOM   4538 N N    . GLY A 1 339 ? 6.675   -28.480 6.945   1.00 20.25  ? 303 GLY A N    1 
ATOM   4539 C CA   . GLY A 1 339 ? 7.352   -27.630 7.879   1.00 18.23  ? 303 GLY A CA   1 
ATOM   4540 C C    . GLY A 1 339 ? 6.985   -26.175 7.752   1.00 16.15  ? 303 GLY A C    1 
ATOM   4541 O O    . GLY A 1 339 ? 7.437   -25.370 8.555   1.00 16.35  ? 303 GLY A O    1 
ATOM   4542 H H    . GLY A 1 339 ? 6.948   -28.399 6.133   1.00 24.28  ? 303 GLY A H    1 
ATOM   4543 H HA2  . GLY A 1 339 ? 7.137   -27.916 8.780   1.00 21.87  ? 303 GLY A HA2  1 
ATOM   4544 H HA3  . GLY A 1 339 ? 8.309   -27.711 7.743   1.00 21.87  ? 303 GLY A HA3  1 
ATOM   4545 N N    . ALA A 1 340 ? 6.113   -25.851 6.801   1.00 18.31  ? 304 ALA A N    1 
ATOM   4546 C CA   . ALA A 1 340 ? 5.798   -24.457 6.496   1.00 16.06  ? 304 ALA A CA   1 
ATOM   4547 C C    . ALA A 1 340 ? 5.270   -23.677 7.695   1.00 16.76  ? 304 ALA A C    1 
ATOM   4548 O O    . ALA A 1 340 ? 4.497   -24.176 8.520   1.00 17.89  ? 304 ALA A O    1 
ATOM   4549 C CB   . ALA A 1 340 ? 4.785   -24.388 5.370   1.00 19.70  ? 304 ALA A CB   1 
ATOM   4550 H H    . ALA A 1 340 ? 5.688   -26.420 6.316   1.00 21.96  ? 304 ALA A H    1 
ATOM   4551 H HA   . ALA A 1 340 ? 6.626   -24.029 6.226   1.00 19.27  ? 304 ALA A HA   1 
ATOM   4552 H HB1  . ALA A 1 340 ? 4.527   -23.463 5.233   1.00 23.63  ? 304 ALA A HB1  1 
ATOM   4553 H HB2  . ALA A 1 340 ? 5.187   -24.742 4.561   1.00 23.63  ? 304 ALA A HB2  1 
ATOM   4554 H HB3  . ALA A 1 340 ? 4.008   -24.915 5.612   1.00 23.63  ? 304 ALA A HB3  1 
ATOM   4555 N N    . GLN A 1 341 ? 5.678   -22.421 7.769   1.00 17.00  ? 305 GLN A N    1 
ATOM   4556 C CA   . GLN A 1 341 ? 5.294   -21.492 8.813   1.00 19.70  ? 305 GLN A CA   1 
ATOM   4557 C C    . GLN A 1 341 ? 4.814   -20.201 8.167   1.00 18.82  ? 305 GLN A C    1 
ATOM   4558 O O    . GLN A 1 341 ? 5.098   -19.933 6.988   1.00 14.61  ? 305 GLN A O    1 
ATOM   4559 C CB   . GLN A 1 341 ? 6.466   -21.158 9.751   1.00 16.40  ? 305 GLN A CB   1 
ATOM   4560 C CG   . GLN A 1 341 ? 7.084   -22.370 10.408  1.00 17.53  ? 305 GLN A CG   1 
ATOM   4561 C CD   . GLN A 1 341 ? 6.184   -22.968 11.453  1.00 19.37  ? 305 GLN A CD   1 
ATOM   4562 O OE1  . GLN A 1 341 ? 5.130   -22.410 11.813  1.00 16.47  ? 305 GLN A OE1  1 
ATOM   4563 N NE2  . GLN A 1 341 ? 6.577   -24.130 11.943  1.00 18.44  ? 305 GLN A NE2  1 
ATOM   4564 H H    . GLN A 1 341 ? 6.208   -22.066 7.192   1.00 20.38  ? 305 GLN A H    1 
ATOM   4565 H HA   . GLN A 1 341 ? 4.583   -21.888 9.340   1.00 23.63  ? 305 GLN A HA   1 
ATOM   4566 H HB2  . GLN A 1 341 ? 7.159   -20.714 9.237   1.00 19.67  ? 305 GLN A HB2  1 
ATOM   4567 H HB3  . GLN A 1 341 ? 6.145   -20.571 10.453  1.00 19.67  ? 305 GLN A HB3  1 
ATOM   4568 H HG2  . GLN A 1 341 ? 7.255   -23.046 9.734   1.00 21.02  ? 305 GLN A HG2  1 
ATOM   4569 H HG3  . GLN A 1 341 ? 7.914   -22.112 10.837  1.00 21.02  ? 305 GLN A HG3  1 
ATOM   4570 H HE21 . GLN A 1 341 ? 7.304   -24.492 11.661  1.00 22.12  ? 305 GLN A HE21 1 
ATOM   4571 H HE22 . GLN A 1 341 ? 6.106   -24.525 12.545  1.00 22.12  ? 305 GLN A HE22 1 
ATOM   4572 N N    . PRO A 1 342 ? 4.121   -19.362 8.920   1.00 16.14  ? 306 PRO A N    1 
ATOM   4573 C CA   . PRO A 1 342 ? 3.834   -18.022 8.416   1.00 17.25  ? 306 PRO A CA   1 
ATOM   4574 C C    . PRO A 1 342 ? 5.134   -17.381 7.953   1.00 17.66  ? 306 PRO A C    1 
ATOM   4575 O O    . PRO A 1 342 ? 6.174   -17.544 8.577   1.00 18.84  ? 306 PRO A O    1 
ATOM   4576 C CB   . PRO A 1 342 ? 3.245   -17.302 9.626   1.00 19.48  ? 306 PRO A CB   1 
ATOM   4577 C CG   . PRO A 1 342 ? 2.714   -18.354 10.443  1.00 19.83  ? 306 PRO A CG   1 
ATOM   4578 C CD   . PRO A 1 342 ? 3.650   -19.505 10.306  1.00 17.66  ? 306 PRO A CD   1 
ATOM   4579 H HA   . PRO A 1 342 ? 3.174   -18.029 7.705   1.00 20.69  ? 306 PRO A HA   1 
ATOM   4580 H HB2  . PRO A 1 342 ? 3.941   -16.814 10.093  1.00 23.36  ? 306 PRO A HB2  1 
ATOM   4581 H HB3  . PRO A 1 342 ? 2.545   -16.693 9.342   1.00 23.36  ? 306 PRO A HB3  1 
ATOM   4582 H HG2  . PRO A 1 342 ? 2.669   -18.058 11.366  1.00 23.78  ? 306 PRO A HG2  1 
ATOM   4583 H HG3  . PRO A 1 342 ? 1.828   -18.595 10.129  1.00 23.78  ? 306 PRO A HG3  1 
ATOM   4584 H HD2  . PRO A 1 342 ? 4.386   -19.433 10.934  1.00 21.19  ? 306 PRO A HD2  1 
ATOM   4585 H HD3  . PRO A 1 342 ? 3.187   -20.348 10.432  1.00 21.19  ? 306 PRO A HD3  1 
ATOM   4586 N N    . TYR A 1 343 ? 5.063   -16.696 6.807   1.00 16.66  ? 307 TYR A N    1 
ATOM   4587 C CA   . TYR A 1 343 ? 6.184   -15.935 6.300   1.00 18.68  ? 307 TYR A CA   1 
ATOM   4588 C C    . TYR A 1 343 ? 7.357   -16.848 6.014   1.00 17.17  ? 307 TYR A C    1 
ATOM   4589 O O    . TYR A 1 343 ? 8.518   -16.449 6.110   1.00 18.58  ? 307 TYR A O    1 
ATOM   4590 C CB   . TYR A 1 343 ? 6.540   -14.809 7.262   1.00 17.62  ? 307 TYR A CB   1 
ATOM   4591 C CG   . TYR A 1 343 ? 5.519   -13.739 7.194   1.00 19.05  ? 307 TYR A CG   1 
ATOM   4592 C CD1  . TYR A 1 343 ? 4.355   -13.832 7.948   1.00 15.87  ? 307 TYR A CD1  1 
ATOM   4593 C CD2  . TYR A 1 343 ? 5.646   -12.690 6.310   1.00 18.19  ? 307 TYR A CD2  1 
ATOM   4594 C CE1  . TYR A 1 343 ? 3.376   -12.861 7.866   1.00 15.03  ? 307 TYR A CE1  1 
ATOM   4595 C CE2  . TYR A 1 343 ? 4.666   -11.714 6.207   1.00 16.79  ? 307 TYR A CE2  1 
ATOM   4596 C CZ   . TYR A 1 343 ? 3.530   -11.808 6.992   1.00 17.96  ? 307 TYR A CZ   1 
ATOM   4597 O OH   . TYR A 1 343 ? 2.542   -10.845 6.904   1.00 23.27  ? 307 TYR A OH   1 
ATOM   4598 H H    . TYR A 1 343 ? 4.364   -16.663 6.307   1.00 19.98  ? 307 TYR A H    1 
ATOM   4599 H HA   . TYR A 1 343 ? 5.953   -15.514 5.457   1.00 22.41  ? 307 TYR A HA   1 
ATOM   4600 H HB2  . TYR A 1 343 ? 6.570   -15.153 8.169   1.00 21.14  ? 307 TYR A HB2  1 
ATOM   4601 H HB3  . TYR A 1 343 ? 7.401   -14.434 7.021   1.00 21.14  ? 307 TYR A HB3  1 
ATOM   4602 H HD1  . TYR A 1 343 ? 4.233   -14.558 8.516   1.00 19.03  ? 307 TYR A HD1  1 
ATOM   4603 H HD2  . TYR A 1 343 ? 6.402   -12.635 5.773   1.00 21.82  ? 307 TYR A HD2  1 
ATOM   4604 H HE1  . TYR A 1 343 ? 2.615   -12.918 8.399   1.00 18.03  ? 307 TYR A HE1  1 
ATOM   4605 H HE2  . TYR A 1 343 ? 4.772   -11.003 5.617   1.00 20.14  ? 307 TYR A HE2  1 
ATOM   4606 H HH   . TYR A 1 343 ? 1.939   -11.000 7.468   1.00 27.91  ? 307 TYR A HH   1 
ATOM   4607 N N    . SER A 1 344 ? 7.046   -18.080 5.639   1.00 17.26  ? 308 SER A N    1 
ATOM   4608 C CA   . SER A 1 344 ? 7.999   -18.953 4.976   1.00 16.01  ? 308 SER A CA   1 
ATOM   4609 C C    . SER A 1 344 ? 7.555   -19.092 3.525   1.00 16.23  ? 308 SER A C    1 
ATOM   4610 O O    . SER A 1 344 ? 6.370   -19.011 3.205   1.00 19.60  ? 308 SER A O    1 
ATOM   4611 C CB   . SER A 1 344 ? 8.089   -20.291 5.658   1.00 18.36  ? 308 SER A CB   1 
ATOM   4612 O OG   . SER A 1 344 ? 6.908   -21.009 5.465   1.00 18.37  ? 308 SER A OG   1 
ATOM   4613 H H    . SER A 1 344 ? 6.273   -18.438 5.760   1.00 20.70  ? 308 SER A H    1 
ATOM   4614 H HA   . SER A 1 344 ? 8.896   -18.585 5.000   1.00 19.20  ? 308 SER A HA   1 
ATOM   4615 H HB2  . SER A 1 344 ? 8.830   -20.791 5.282   1.00 22.02  ? 308 SER A HB2  1 
ATOM   4616 H HB3  . SER A 1 344 ? 8.227   -20.156 6.608   1.00 22.02  ? 308 SER A HB3  1 
ATOM   4617 H HG   . SER A 1 344 ? 6.249   -20.550 5.711   1.00 22.03  ? 308 SER A HG   1 
ATOM   4618 N N    . TYR A 1 345 ? 8.511   -19.247 2.649   1.00 15.36  ? 309 TYR A N    1 
ATOM   4619 C CA   . TYR A 1 345 ? 8.249   -19.197 1.218   1.00 14.68  ? 309 TYR A CA   1 
ATOM   4620 C C    . TYR A 1 345 ? 9.011   -20.333 0.564   1.00 15.49  ? 309 TYR A C    1 
ATOM   4621 O O    . TYR A 1 345 ? 10.113  -20.668 0.986   1.00 16.24  ? 309 TYR A O    1 
ATOM   4622 C CB   . TYR A 1 345 ? 8.698   -17.881 0.611   1.00 15.47  ? 309 TYR A CB   1 
ATOM   4623 C CG   . TYR A 1 345 ? 8.004   -16.667 1.216   1.00 15.50  ? 309 TYR A CG   1 
ATOM   4624 C CD1  . TYR A 1 345 ? 8.468   -16.079 2.398   1.00 19.46  ? 309 TYR A CD1  1 
ATOM   4625 C CD2  . TYR A 1 345 ? 6.864   -16.139 0.636   1.00 18.06  ? 309 TYR A CD2  1 
ATOM   4626 C CE1  . TYR A 1 345 ? 7.840   -14.978 2.938   1.00 18.74  ? 309 TYR A CE1  1 
ATOM   4627 C CE2  . TYR A 1 345 ? 6.236   -15.060 1.175   1.00 17.36  ? 309 TYR A CE2  1 
ATOM   4628 C CZ   . TYR A 1 345 ? 6.733   -14.479 2.326   1.00 16.13  ? 309 TYR A CZ   1 
ATOM   4629 O OH   . TYR A 1 345 ? 6.115   -13.400 2.900   1.00 18.45  ? 309 TYR A OH   1 
ATOM   4630 H H    . TYR A 1 345 ? 9.335   -19.386 2.851   1.00 18.42  ? 309 TYR A H    1 
ATOM   4631 H HA   . TYR A 1 345 ? 7.300   -19.301 1.050   1.00 17.61  ? 309 TYR A HA   1 
ATOM   4632 H HB2  . TYR A 1 345 ? 9.652   -17.779 0.754   1.00 18.55  ? 309 TYR A HB2  1 
ATOM   4633 H HB3  . TYR A 1 345 ? 8.504   -17.891 -0.339  1.00 18.55  ? 309 TYR A HB3  1 
ATOM   4634 H HD1  . TYR A 1 345 ? 9.212   -16.437 2.827   1.00 23.34  ? 309 TYR A HD1  1 
ATOM   4635 H HD2  . TYR A 1 345 ? 6.521   -16.529 -0.135  1.00 21.67  ? 309 TYR A HD2  1 
ATOM   4636 H HE1  . TYR A 1 345 ? 8.169   -14.581 3.711   1.00 22.48  ? 309 TYR A HE1  1 
ATOM   4637 H HE2  . TYR A 1 345 ? 5.474   -14.713 0.770   1.00 20.82  ? 309 TYR A HE2  1 
ATOM   4638 H HH   . TYR A 1 345 ? 5.517   -13.106 2.388   1.00 22.13  ? 309 TYR A HH   1 
ATOM   4639 N N    . PHE A 1 346 ? 8.410   -20.891 -0.484  1.00 18.54  ? 310 PHE A N    1 
ATOM   4640 C CA   . PHE A 1 346 ? 8.979   -21.972 -1.281  1.00 21.16  ? 310 PHE A CA   1 
ATOM   4641 C C    . PHE A 1 346 ? 9.642   -21.365 -2.512  1.00 19.01  ? 310 PHE A C    1 
ATOM   4642 O O    . PHE A 1 346 ? 9.087   -20.483 -3.141  1.00 16.48  ? 310 PHE A O    1 
ATOM   4643 C CB   . PHE A 1 346 ? 7.861   -22.924 -1.687  1.00 21.18  ? 310 PHE A CB   1 
ATOM   4644 C CG   . PHE A 1 346 ? 8.324   -24.229 -2.268  1.00 22.20  ? 310 PHE A CG   1 
ATOM   4645 C CD1  . PHE A 1 346 ? 9.236   -25.021 -1.625  1.00 22.91  ? 310 PHE A CD1  1 
ATOM   4646 C CD2  . PHE A 1 346 ? 7.811   -24.653 -3.482  1.00 20.12  ? 310 PHE A CD2  1 
ATOM   4647 C CE1  . PHE A 1 346 ? 9.603   -26.222 -2.173  1.00 22.25  ? 310 PHE A CE1  1 
ATOM   4648 C CE2  . PHE A 1 346 ? 8.168   -25.846 -4.017  1.00 23.54  ? 310 PHE A CE2  1 
ATOM   4649 C CZ   . PHE A 1 346 ? 9.082   -26.617 -3.378  1.00 19.87  ? 310 PHE A CZ   1 
ATOM   4650 H H    . PHE A 1 346 ? 7.635   -20.647 -0.765  1.00 22.24  ? 310 PHE A H    1 
ATOM   4651 H HA   . PHE A 1 346 ? 9.649   -22.472 -0.791  1.00 25.38  ? 310 PHE A HA   1 
ATOM   4652 H HB2  . PHE A 1 346 ? 7.330   -23.128 -0.901  1.00 25.40  ? 310 PHE A HB2  1 
ATOM   4653 H HB3  . PHE A 1 346 ? 7.311   -22.486 -2.355  1.00 25.40  ? 310 PHE A HB3  1 
ATOM   4654 H HD1  . PHE A 1 346 ? 9.606   -24.745 -0.818  1.00 27.49  ? 310 PHE A HD1  1 
ATOM   4655 H HD2  . PHE A 1 346 ? 7.211   -24.109 -3.939  1.00 24.13  ? 310 PHE A HD2  1 
ATOM   4656 H HE1  . PHE A 1 346 ? 10.208  -26.771 -1.727  1.00 26.68  ? 310 PHE A HE1  1 
ATOM   4657 H HE2  . PHE A 1 346 ? 7.789   -26.133 -4.816  1.00 28.24  ? 310 PHE A HE2  1 
ATOM   4658 H HZ   . PHE A 1 346 ? 9.356   -27.420 -3.759  1.00 23.84  ? 310 PHE A HZ   1 
ATOM   4659 N N    . GLN A 1 347 ? 10.810  -21.857 -2.863  1.00 20.73  ? 311 GLN A N    1 
ATOM   4660 C CA   . GLN A 1 347 ? 11.409  -21.540 -4.152  1.00 17.78  ? 311 GLN A CA   1 
ATOM   4661 C C    . GLN A 1 347 ? 11.677  -22.847 -4.884  1.00 20.85  ? 311 GLN A C    1 
ATOM   4662 O O    . GLN A 1 347 ? 12.142  -23.809 -4.278  1.00 21.46  ? 311 GLN A O    1 
ATOM   4663 C CB   . GLN A 1 347 ? 12.695  -20.755 -3.986  1.00 18.55  ? 311 GLN A CB   1 
ATOM   4664 C CG   . GLN A 1 347 ? 13.264  -20.274 -5.320  1.00 19.32  ? 311 GLN A CG   1 
ATOM   4665 C CD   . GLN A 1 347 ? 14.724  -19.872 -5.202  1.00 19.05  ? 311 GLN A CD   1 
ATOM   4666 O OE1  . GLN A 1 347 ? 15.143  -19.323 -4.184  1.00 21.49  ? 311 GLN A OE1  1 
ATOM   4667 N NE2  . GLN A 1 347 ? 15.518  -20.168 -6.240  1.00 21.11  ? 311 GLN A NE2  1 
ATOM   4668 H H    . GLN A 1 347 ? 11.283  -22.380 -2.371  1.00 24.86  ? 311 GLN A H    1 
ATOM   4669 H HA   . GLN A 1 347 ? 10.806  -20.997 -4.683  1.00 21.32  ? 311 GLN A HA   1 
ATOM   4670 H HB2  . GLN A 1 347 ? 12.522  -19.977 -3.433  1.00 22.25  ? 311 GLN A HB2  1 
ATOM   4671 H HB3  . GLN A 1 347 ? 13.359  -21.322 -3.562  1.00 22.25  ? 311 GLN A HB3  1 
ATOM   4672 H HG2  . GLN A 1 347 ? 13.198  -20.988 -5.972  1.00 23.17  ? 311 GLN A HG2  1 
ATOM   4673 H HG3  . GLN A 1 347 ? 12.761  -19.501 -5.621  1.00 23.17  ? 311 GLN A HG3  1 
ATOM   4674 H HE21 . GLN A 1 347 ? 15.194  -20.567 -6.930  1.00 25.32  ? 311 GLN A HE21 1 
ATOM   4675 H HE22 . GLN A 1 347 ? 16.352  -19.960 -6.217  1.00 25.32  ? 311 GLN A HE22 1 
ATOM   4676 N N    . TYR A 1 348 ? 11.364  -22.882 -6.178  1.00 21.95  ? 312 TYR A N    1 
ATOM   4677 C CA   . TYR A 1 348 ? 11.434  -24.130 -6.914  1.00 23.46  ? 312 TYR A CA   1 
ATOM   4678 C C    . TYR A 1 348 ? 11.987  -23.925 -8.314  1.00 26.96  ? 312 TYR A C    1 
ATOM   4679 O O    . TYR A 1 348 ? 11.623  -22.973 -9.008  1.00 22.66  ? 312 TYR A O    1 
ATOM   4680 C CB   . TYR A 1 348 ? 10.062  -24.781 -7.031  1.00 24.42  ? 312 TYR A CB   1 
ATOM   4681 C CG   . TYR A 1 348 ? 10.140  -26.242 -7.429  1.00 25.31  ? 312 TYR A CG   1 
ATOM   4682 C CD1  . TYR A 1 348 ? 10.765  -27.166 -6.607  1.00 24.00  ? 312 TYR A CD1  1 
ATOM   4683 C CD2  . TYR A 1 348 ? 9.605   -26.691 -8.631  1.00 32.79  ? 312 TYR A CD2  1 
ATOM   4684 C CE1  . TYR A 1 348 ? 10.836  -28.505 -6.951  1.00 25.48  ? 312 TYR A CE1  1 
ATOM   4685 C CE2  . TYR A 1 348 ? 9.677   -28.050 -8.987  1.00 29.23  ? 312 TYR A CE2  1 
ATOM   4686 C CZ   . TYR A 1 348 ? 10.297  -28.934 -8.146  1.00 32.13  ? 312 TYR A CZ   1 
ATOM   4687 O OH   . TYR A 1 348 ? 10.377  -30.271 -8.482  1.00 29.30  ? 312 TYR A OH   1 
ATOM   4688 H H    . TYR A 1 348 ? 11.112  -22.202 -6.641  1.00 26.34  ? 312 TYR A H    1 
ATOM   4689 H HA   . TYR A 1 348 ? 12.043  -24.716 -6.438  1.00 28.15  ? 312 TYR A HA   1 
ATOM   4690 H HB2  . TYR A 1 348 ? 9.611   -24.727 -6.174  1.00 29.30  ? 312 TYR A HB2  1 
ATOM   4691 H HB3  . TYR A 1 348 ? 9.546   -24.313 -7.707  1.00 29.30  ? 312 TYR A HB3  1 
ATOM   4692 H HD1  . TYR A 1 348 ? 11.144  -26.880 -5.807  1.00 28.79  ? 312 TYR A HD1  1 
ATOM   4693 H HD2  . TYR A 1 348 ? 9.196   -26.086 -9.207  1.00 39.34  ? 312 TYR A HD2  1 
ATOM   4694 H HE1  . TYR A 1 348 ? 11.245  -29.113 -6.379  1.00 30.57  ? 312 TYR A HE1  1 
ATOM   4695 H HE2  . TYR A 1 348 ? 9.307   -28.345 -9.787  1.00 35.07  ? 312 TYR A HE2  1 
ATOM   4696 H HH   . TYR A 1 348 ? 9.869   -30.435 -9.130  1.00 35.15  ? 312 TYR A HH   1 
ATOM   4697 N N    . GLY A 1 349 ? 12.844  -24.858 -8.718  1.00 23.96  ? 313 GLY A N    1 
ATOM   4698 C CA   . GLY A 1 349 ? 13.420  -24.879 -10.053 1.00 28.25  ? 313 GLY A CA   1 
ATOM   4699 C C    . GLY A 1 349 ? 14.594  -25.841 -10.069 1.00 28.34  ? 313 GLY A C    1 
ATOM   4700 O O    . GLY A 1 349 ? 14.665  -26.772 -9.256  1.00 27.32  ? 313 GLY A O    1 
ATOM   4701 H H    . GLY A 1 349 ? 13.115  -25.507 -8.223  1.00 28.74  ? 313 GLY A H    1 
ATOM   4702 H HA2  . GLY A 1 349 ? 12.757  -25.171 -10.698 1.00 33.89  ? 313 GLY A HA2  1 
ATOM   4703 H HA3  . GLY A 1 349 ? 13.729  -23.992 -10.297 1.00 33.89  ? 313 GLY A HA3  1 
ATOM   4704 N N    . TRP A 1 350 ? 15.534  -25.586 -10.974 1.00 30.13  ? 314 TRP A N    1 
ATOM   4705 C CA   . TRP A 1 350 ? 16.726  -26.427 -11.062 1.00 28.61  ? 314 TRP A CA   1 
ATOM   4706 C C    . TRP A 1 350 ? 17.989  -25.581 -11.141 1.00 33.13  ? 314 TRP A C    1 
ATOM   4707 O O    . TRP A 1 350 ? 18.977  -25.988 -11.756 1.00 27.05  ? 314 TRP A O    1 
ATOM   4708 C CB   . TRP A 1 350 ? 16.644  -27.376 -12.260 1.00 36.07  ? 314 TRP A CB   1 
ATOM   4709 C CG   . TRP A 1 350 ? 16.261  -26.725 -13.542 1.00 33.90  ? 314 TRP A CG   1 
ATOM   4710 C CD1  . TRP A 1 350 ? 17.102  -26.256 -14.502 1.00 36.80  ? 314 TRP A CD1  1 
ATOM   4711 C CD2  . TRP A 1 350 ? 14.934  -26.476 -14.010 1.00 33.79  ? 314 TRP A CD2  1 
ATOM   4712 N NE1  . TRP A 1 350 ? 16.382  -25.724 -15.544 1.00 30.87  ? 314 TRP A NE1  1 
ATOM   4713 C CE2  . TRP A 1 350 ? 15.047  -25.843 -15.265 1.00 30.52  ? 314 TRP A CE2  1 
ATOM   4714 C CE3  . TRP A 1 350 ? 13.656  -26.723 -13.488 1.00 31.25  ? 314 TRP A CE3  1 
ATOM   4715 C CZ2  . TRP A 1 350 ? 13.935  -25.459 -16.007 1.00 35.25  ? 314 TRP A CZ2  1 
ATOM   4716 C CZ3  . TRP A 1 350 ? 12.557  -26.333 -14.221 1.00 36.79  ? 314 TRP A CZ3  1 
ATOM   4717 C CH2  . TRP A 1 350 ? 12.701  -25.715 -15.472 1.00 35.65  ? 314 TRP A CH2  1 
ATOM   4718 H H    . TRP A 1 350 ? 15.504  -24.940 -11.541 1.00 36.15  ? 314 TRP A H    1 
ATOM   4719 H HA   . TRP A 1 350 ? 16.779  -26.967 -10.258 1.00 34.32  ? 314 TRP A HA   1 
ATOM   4720 H HB2  . TRP A 1 350 ? 17.514  -27.785 -12.389 1.00 43.27  ? 314 TRP A HB2  1 
ATOM   4721 H HB3  . TRP A 1 350 ? 15.981  -28.058 -12.069 1.00 43.27  ? 314 TRP A HB3  1 
ATOM   4722 H HD1  . TRP A 1 350 ? 18.030  -26.291 -14.459 1.00 44.15  ? 314 TRP A HD1  1 
ATOM   4723 H HE1  . TRP A 1 350 ? 16.715  -25.374 -16.255 1.00 37.03  ? 314 TRP A HE1  1 
ATOM   4724 H HE3  . TRP A 1 350 ? 13.553  -27.142 -12.664 1.00 37.49  ? 314 TRP A HE3  1 
ATOM   4725 H HZ2  . TRP A 1 350 ? 14.026  -25.044 -16.834 1.00 42.29  ? 314 TRP A HZ2  1 
ATOM   4726 H HZ3  . TRP A 1 350 ? 11.705  -26.483 -13.880 1.00 44.14  ? 314 TRP A HZ3  1 
ATOM   4727 H HH2  . TRP A 1 350 ? 11.940  -25.473 -15.949 1.00 42.77  ? 314 TRP A HH2  1 
ATOM   4728 N N    . GLY A 1 351 ? 17.967  -24.403 -10.527 1.00 26.65  ? 315 GLY A N    1 
ATOM   4729 C CA   . GLY A 1 351 ? 19.134  -23.550 -10.525 1.00 30.45  ? 315 GLY A CA   1 
ATOM   4730 C C    . GLY A 1 351 ? 18.738  -22.097 -10.318 1.00 29.89  ? 315 GLY A C    1 
ATOM   4731 O O    . GLY A 1 351 ? 17.697  -21.793 -9.732  1.00 25.46  ? 315 GLY A O    1 
ATOM   4732 H H    . GLY A 1 351 ? 17.289  -24.081 -10.107 1.00 31.97  ? 315 GLY A H    1 
ATOM   4733 H HA2  . GLY A 1 351 ? 19.733  -23.816 -9.810  1.00 36.53  ? 315 GLY A HA2  1 
ATOM   4734 H HA3  . GLY A 1 351 ? 19.599  -23.630 -11.372 1.00 36.53  ? 315 GLY A HA3  1 
ATOM   4735 N N    . TRP A 1 352 ? 19.620  -21.223 -10.791 1.00 26.32  ? 316 TRP A N    1 
ATOM   4736 C CA   . TRP A 1 352 ? 19.603  -19.819 -10.414 1.00 23.80  ? 316 TRP A CA   1 
ATOM   4737 C C    . TRP A 1 352 ? 19.495  -18.875 -11.598 1.00 24.55  ? 316 TRP A C    1 
ATOM   4738 O O    . TRP A 1 352 ? 19.527  -17.649 -11.399 1.00 24.20  ? 316 TRP A O    1 
ATOM   4739 C CB   . TRP A 1 352 ? 20.867  -19.514 -9.611  1.00 26.59  ? 316 TRP A CB   1 
ATOM   4740 C CG   . TRP A 1 352 ? 20.950  -20.375 -8.427  1.00 27.04  ? 316 TRP A CG   1 
ATOM   4741 C CD1  . TRP A 1 352 ? 21.701  -21.512 -8.277  1.00 27.59  ? 316 TRP A CD1  1 
ATOM   4742 C CD2  . TRP A 1 352 ? 20.194  -20.232 -7.219  1.00 22.53  ? 316 TRP A CD2  1 
ATOM   4743 N NE1  . TRP A 1 352 ? 21.490  -22.048 -7.038  1.00 26.81  ? 316 TRP A NE1  1 
ATOM   4744 C CE2  . TRP A 1 352 ? 20.565  -21.284 -6.371  1.00 22.63  ? 316 TRP A CE2  1 
ATOM   4745 C CE3  . TRP A 1 352 ? 19.265  -19.294 -6.765  1.00 25.14  ? 316 TRP A CE3  1 
ATOM   4746 C CZ2  . TRP A 1 352 ? 20.053  -21.424 -5.092  1.00 26.81  ? 316 TRP A CZ2  1 
ATOM   4747 C CZ3  . TRP A 1 352 ? 18.752  -19.440 -5.484  1.00 26.83  ? 316 TRP A CZ3  1 
ATOM   4748 C CH2  . TRP A 1 352 ? 19.136  -20.501 -4.673  1.00 25.77  ? 316 TRP A CH2  1 
ATOM   4749 H H    . TRP A 1 352 ? 20.249  -21.425 -11.343 1.00 31.57  ? 316 TRP A H    1 
ATOM   4750 H HA   . TRP A 1 352 ? 18.831  -19.643 -9.854  1.00 28.55  ? 316 TRP A HA   1 
ATOM   4751 H HB2  . TRP A 1 352 ? 21.648  -19.674 -10.164 1.00 31.89  ? 316 TRP A HB2  1 
ATOM   4752 H HB3  . TRP A 1 352 ? 20.850  -18.589 -9.320  1.00 31.89  ? 316 TRP A HB3  1 
ATOM   4753 H HD1  . TRP A 1 352 ? 22.269  -21.866 -8.922  1.00 33.10  ? 316 TRP A HD1  1 
ATOM   4754 H HE1  . TRP A 1 352 ? 21.875  -22.751 -6.726  1.00 32.16  ? 316 TRP A HE1  1 
ATOM   4755 H HE3  . TRP A 1 352 ? 18.995  -18.589 -7.309  1.00 30.16  ? 316 TRP A HE3  1 
ATOM   4756 H HZ2  . TRP A 1 352 ? 20.323  -22.121 -4.538  1.00 32.17  ? 316 TRP A HZ2  1 
ATOM   4757 H HZ3  . TRP A 1 352 ? 18.141  -18.817 -5.163  1.00 32.18  ? 316 TRP A HZ3  1 
ATOM   4758 H HH2  . TRP A 1 352 ? 18.761  -20.584 -3.826  1.00 30.92  ? 316 TRP A HH2  1 
ATOM   4759 N N    . THR A 1 353 ? 19.419  -19.393 -12.818 1.00 23.76  ? 317 THR A N    1 
ATOM   4760 C CA   . THR A 1 353 ? 19.296  -18.545 -13.986 1.00 24.16  ? 317 THR A CA   1 
ATOM   4761 C C    . THR A 1 353 ? 17.820  -18.284 -14.243 1.00 25.94  ? 317 THR A C    1 
ATOM   4762 O O    . THR A 1 353 ? 16.942  -18.989 -13.734 1.00 23.35  ? 317 THR A O    1 
ATOM   4763 C CB   . THR A 1 353 ? 19.926  -19.196 -15.212 1.00 31.40  ? 317 THR A CB   1 
ATOM   4764 O OG1  . THR A 1 353 ? 19.020  -20.177 -15.730 1.00 34.30  ? 317 THR A OG1  1 
ATOM   4765 C CG2  . THR A 1 353 ? 21.246  -19.872 -14.843 1.00 43.67  ? 317 THR A CG2  1 
ATOM   4766 H H    . THR A 1 353 ? 19.438  -20.235 -12.991 1.00 28.50  ? 317 THR A H    1 
ATOM   4767 H HA   . THR A 1 353 ? 19.759  -17.705 -13.837 1.00 28.98  ? 317 THR A HA   1 
ATOM   4768 H HB   . THR A 1 353 ? 20.109  -18.523 -15.886 1.00 37.67  ? 317 THR A HB   1 
ATOM   4769 H HG1  . THR A 1 353 ? 19.445  -20.767 -16.150 1.00 41.15  ? 317 THR A HG1  1 
ATOM   4770 H HG21 . THR A 1 353 ? 21.591  -20.364 -15.605 1.00 52.39  ? 317 THR A HG21 1 
ATOM   4771 H HG22 . THR A 1 353 ? 21.899  -19.205 -14.578 1.00 52.39  ? 317 THR A HG22 1 
ATOM   4772 H HG23 . THR A 1 353 ? 21.110  -20.488 -14.107 1.00 52.39  ? 317 THR A HG23 1 
ATOM   4773 N N    . LEU A 1 354 ? 17.551  -17.268 -15.059 1.00 26.01  ? 318 LEU A N    1 
ATOM   4774 C CA   . LEU A 1 354 ? 16.168  -17.017 -15.460 1.00 32.19  ? 318 LEU A CA   1 
ATOM   4775 C C    . LEU A 1 354 ? 15.546  -18.267 -16.069 1.00 28.37  ? 318 LEU A C    1 
ATOM   4776 O O    . LEU A 1 354 ? 14.344  -18.532 -15.888 1.00 25.56  ? 318 LEU A O    1 
ATOM   4777 C CB   . LEU A 1 354 ? 16.121  -15.852 -16.445 1.00 26.44  ? 318 LEU A CB   1 
ATOM   4778 C CG   . LEU A 1 354 ? 14.765  -15.403 -16.968 1.00 35.67  ? 318 LEU A CG   1 
ATOM   4779 C CD1  . LEU A 1 354 ? 13.800  -15.143 -15.817 1.00 27.13  ? 318 LEU A CD1  1 
ATOM   4780 C CD2  . LEU A 1 354 ? 14.946  -14.148 -17.835 1.00 32.21  ? 318 LEU A CD2  1 
ATOM   4781 H H    . LEU A 1 354 ? 18.132  -16.725 -15.386 1.00 31.20  ? 318 LEU A H    1 
ATOM   4782 H HA   . LEU A 1 354 ? 15.641  -16.766 -14.685 1.00 38.62  ? 318 LEU A HA   1 
ATOM   4783 H HB2  . LEU A 1 354 ? 16.518  -15.082 -16.008 1.00 31.72  ? 318 LEU A HB2  1 
ATOM   4784 H HB3  . LEU A 1 354 ? 16.648  -16.102 -17.220 1.00 31.72  ? 318 LEU A HB3  1 
ATOM   4785 H HG   . LEU A 1 354 ? 14.373  -16.103 -17.513 1.00 42.79  ? 318 LEU A HG   1 
ATOM   4786 H HD11 . LEU A 1 354 ? 12.979  -14.767 -16.171 1.00 32.54  ? 318 LEU A HD11 1 
ATOM   4787 H HD12 . LEU A 1 354 ? 13.612  -15.982 -15.366 1.00 32.54  ? 318 LEU A HD12 1 
ATOM   4788 H HD13 . LEU A 1 354 ? 14.209  -14.519 -15.197 1.00 32.54  ? 318 LEU A HD13 1 
ATOM   4789 H HD21 . LEU A 1 354 ? 14.072  -13.811 -18.089 1.00 38.64  ? 318 LEU A HD21 1 
ATOM   4790 H HD22 . LEU A 1 354 ? 15.424  -13.477 -17.324 1.00 38.64  ? 318 LEU A HD22 1 
ATOM   4791 H HD23 . LEU A 1 354 ? 15.452  -14.383 -18.629 1.00 38.64  ? 318 LEU A HD23 1 
ATOM   4792 N N    . SER A 1 355 ? 16.343  -19.065 -16.767 1.00 27.77  ? 319 SER A N    1 
ATOM   4793 C CA   . SER A 1 355 ? 15.831  -20.230 -17.465 1.00 30.54  ? 319 SER A CA   1 
ATOM   4794 C C    . SER A 1 355 ? 15.750  -21.472 -16.580 1.00 33.81  ? 319 SER A C    1 
ATOM   4795 O O    . SER A 1 355 ? 15.408  -22.547 -17.082 1.00 32.16  ? 319 SER A O    1 
ATOM   4796 C CB   . SER A 1 355 ? 16.690  -20.498 -18.710 1.00 40.08  ? 319 SER A CB   1 
ATOM   4797 O OG   . SER A 1 355 ? 18.006  -20.898 -18.349 1.00 45.89  ? 319 SER A OG   1 
ATOM   4798 H H    . SER A 1 355 ? 17.191  -18.949 -16.851 1.00 33.31  ? 319 SER A H    1 
ATOM   4799 H HA   . SER A 1 355 ? 14.927  -20.047 -17.765 1.00 36.64  ? 319 SER A HA   1 
ATOM   4800 H HB2  . SER A 1 355 ? 16.278  -21.206 -19.230 1.00 48.09  ? 319 SER A HB2  1 
ATOM   4801 H HB3  . SER A 1 355 ? 16.742  -19.686 -19.237 1.00 48.09  ? 319 SER A HB3  1 
ATOM   4802 H HG   . SER A 1 355 ? 18.471  -21.012 -19.040 1.00 55.06  ? 319 SER A HG   1 
ATOM   4803 N N    . SER A 1 356 ? 15.976  -21.333 -15.264 1.00 29.57  ? 320 SER A N    1 
ATOM   4804 C CA   . SER A 1 356 ? 16.078  -22.455 -14.337 1.00 30.68  ? 320 SER A CA   1 
ATOM   4805 C C    . SER A 1 356 ? 14.784  -22.723 -13.569 1.00 26.23  ? 320 SER A C    1 
ATOM   4806 O O    . SER A 1 356 ? 14.830  -23.242 -12.449 1.00 25.47  ? 320 SER A O    1 
ATOM   4807 C CB   . SER A 1 356 ? 17.207  -22.216 -13.336 1.00 27.63  ? 320 SER A CB   1 
ATOM   4808 O OG   . SER A 1 356 ? 18.461  -22.126 -13.966 1.00 28.54  ? 320 SER A OG   1 
ATOM   4809 H H    . SER A 1 356 ? 16.076  -20.570 -14.879 1.00 35.47  ? 320 SER A H    1 
ATOM   4810 H HA   . SER A 1 356 ? 16.280  -23.244 -14.864 1.00 36.81  ? 320 SER A HA   1 
ATOM   4811 H HB2  . SER A 1 356 ? 17.034  -21.385 -12.866 1.00 33.14  ? 320 SER A HB2  1 
ATOM   4812 H HB3  . SER A 1 356 ? 17.227  -22.955 -12.708 1.00 33.14  ? 320 SER A HB3  1 
ATOM   4813 H HG   . SER A 1 356 ? 18.616  -22.827 -14.402 1.00 34.23  ? 320 SER A HG   1 
ATOM   4814 N N    . GLY A 1 357 ? 13.639  -22.361 -14.129 1.00 26.88  ? 321 GLY A N    1 
ATOM   4815 C CA   . GLY A 1 357 ? 12.376  -22.738 -13.522 1.00 22.95  ? 321 GLY A CA   1 
ATOM   4816 C C    . GLY A 1 357 ? 11.433  -21.582 -13.273 1.00 25.22  ? 321 GLY A C    1 
ATOM   4817 O O    . GLY A 1 357 ? 10.217  -21.783 -13.248 1.00 23.13  ? 321 GLY A O    1 
ATOM   4818 H H    . GLY A 1 357 ? 13.569  -21.902 -14.853 1.00 32.24  ? 321 GLY A H    1 
ATOM   4819 H HA2  . GLY A 1 357 ? 11.925  -23.369 -14.104 1.00 27.53  ? 321 GLY A HA2  1 
ATOM   4820 H HA3  . GLY A 1 357 ? 12.553  -23.166 -12.670 1.00 27.53  ? 321 GLY A HA3  1 
ATOM   4821 N N    . SER A 1 358 ? 11.965  -20.369 -13.115 1.00 24.33  ? 322 SER A N    1 
ATOM   4822 C CA   . SER A 1 358 ? 11.109  -19.247 -12.739 1.00 28.58  ? 322 SER A CA   1 
ATOM   4823 C C    . SER A 1 358 ? 9.994   -19.012 -13.742 1.00 29.35  ? 322 SER A C    1 
ATOM   4824 O O    . SER A 1 358 ? 8.932   -18.506 -13.373 1.00 26.02  ? 322 SER A O    1 
ATOM   4825 C CB   . SER A 1 358 ? 11.941  -17.969 -12.589 1.00 26.09  ? 322 SER A CB   1 
ATOM   4826 O OG   . SER A 1 358 ? 12.748  -18.040 -11.423 1.00 24.12  ? 322 SER A OG   1 
ATOM   4827 H H    . SER A 1 358 ? 12.797  -20.174 -13.217 1.00 29.18  ? 322 SER A H    1 
ATOM   4828 H HA   . SER A 1 358 ? 10.706  -19.457 -11.882 1.00 34.29  ? 322 SER A HA   1 
ATOM   4829 H HB2  . SER A 1 358 ? 12.514  -17.869 -13.366 1.00 31.30  ? 322 SER A HB2  1 
ATOM   4830 H HB3  . SER A 1 358 ? 11.345  -17.208 -12.517 1.00 31.30  ? 322 SER A HB3  1 
ATOM   4831 H HG   . SER A 1 358 ? 13.312  -18.658 -11.501 1.00 28.93  ? 322 SER A HG   1 
ATOM   4832 N N    . LEU A 1 359 ? 10.209  -19.362 -15.008 1.00 24.95  ? 323 LEU A N    1 
ATOM   4833 C CA   . LEU A 1 359 ? 9.258   -19.073 -16.065 1.00 27.38  ? 323 LEU A CA   1 
ATOM   4834 C C    . LEU A 1 359 ? 8.443   -20.292 -16.463 1.00 31.44  ? 323 LEU A C    1 
ATOM   4835 O O    . LEU A 1 359 ? 7.747   -20.250 -17.477 1.00 27.68  ? 323 LEU A O    1 
ATOM   4836 C CB   . LEU A 1 359 ? 9.983   -18.510 -17.291 1.00 32.01  ? 323 LEU A CB   1 
ATOM   4837 C CG   . LEU A 1 359 ? 10.593  -17.129 -17.090 1.00 25.38  ? 323 LEU A CG   1 
ATOM   4838 C CD1  . LEU A 1 359 ? 11.346  -16.632 -18.356 1.00 31.29  ? 323 LEU A CD1  1 
ATOM   4839 C CD2  . LEU A 1 359 ? 9.526   -16.127 -16.689 1.00 25.11  ? 323 LEU A CD2  1 
ATOM   4840 H H    . LEU A 1 359 ? 10.913  -19.775 -15.279 1.00 29.93  ? 323 LEU A H    1 
ATOM   4841 H HA   . LEU A 1 359 ? 8.644   -18.394 -15.746 1.00 32.84  ? 323 LEU A HA   1 
ATOM   4842 H HB2  . LEU A 1 359 ? 10.703  -19.116 -17.529 1.00 38.40  ? 323 LEU A HB2  1 
ATOM   4843 H HB3  . LEU A 1 359 ? 9.349   -18.446 -18.022 1.00 38.40  ? 323 LEU A HB3  1 
ATOM   4844 H HG   . LEU A 1 359 ? 11.245  -17.195 -16.375 1.00 30.44  ? 323 LEU A HG   1 
ATOM   4845 H HD11 . LEU A 1 359 ? 11.719  -15.755 -18.178 1.00 37.54  ? 323 LEU A HD11 1 
ATOM   4846 H HD12 . LEU A 1 359 ? 12.057  -17.257 -18.566 1.00 37.54  ? 323 LEU A HD12 1 
ATOM   4847 H HD13 . LEU A 1 359 ? 10.721  -16.581 -19.096 1.00 37.54  ? 323 LEU A HD13 1 
ATOM   4848 H HD21 . LEU A 1 359 ? 9.863   -15.230 -16.836 1.00 30.12  ? 323 LEU A HD21 1 
ATOM   4849 H HD22 . LEU A 1 359 ? 8.735   -16.275 -17.231 1.00 30.12  ? 323 LEU A HD22 1 
ATOM   4850 H HD23 . LEU A 1 359 ? 9.312   -16.251 -15.751 1.00 30.12  ? 323 LEU A HD23 1 
ATOM   4851 N N    . HIS A 1 360 ? 8.514   -21.363 -15.688 1.00 29.92  ? 324 HIS A N    1 
ATOM   4852 C CA   . HIS A 1 360 ? 7.728   -22.560 -15.916 1.00 31.36  ? 324 HIS A CA   1 
ATOM   4853 C C    . HIS A 1 360 ? 6.555   -22.575 -14.955 1.00 31.63  ? 324 HIS A C    1 
ATOM   4854 O O    . HIS A 1 360 ? 6.616   -22.001 -13.867 1.00 31.46  ? 324 HIS A O    1 
ATOM   4855 C CB   . HIS A 1 360 ? 8.578   -23.815 -15.721 1.00 34.01  ? 324 HIS A CB   1 
ATOM   4856 C CG   . HIS A 1 360 ? 9.580   -24.024 -16.806 1.00 36.88  ? 324 HIS A CG   1 
ATOM   4857 N ND1  . HIS A 1 360 ? 9.433   -24.992 -17.776 1.00 38.96  ? 324 HIS A ND1  1 
ATOM   4858 C CD2  . HIS A 1 360 ? 10.737  -23.377 -17.087 1.00 34.95  ? 324 HIS A CD2  1 
ATOM   4859 C CE1  . HIS A 1 360 ? 10.459  -24.934 -18.606 1.00 42.54  ? 324 HIS A CE1  1 
ATOM   4860 N NE2  . HIS A 1 360 ? 11.263  -23.962 -18.211 1.00 42.36  ? 324 HIS A NE2  1 
ATOM   4861 H H    . HIS A 1 360 ? 9.027   -21.420 -15.000 1.00 35.90  ? 324 HIS A H    1 
ATOM   4862 H HA   . HIS A 1 360 ? 7.391   -22.572 -16.826 1.00 37.62  ? 324 HIS A HA   1 
ATOM   4863 H HB2  . HIS A 1 360 ? 9.058   -23.740 -14.882 1.00 40.80  ? 324 HIS A HB2  1 
ATOM   4864 H HB3  . HIS A 1 360 ? 7.994   -24.589 -15.702 1.00 40.80  ? 324 HIS A HB3  1 
ATOM   4865 H HD1  . HIS A 1 360 ? 8.777   -25.545 -17.832 1.00 46.74  ? 324 HIS A HD1  1 
ATOM   4866 H HD2  . HIS A 1 360 ? 11.105  -22.669 -16.608 1.00 41.93  ? 324 HIS A HD2  1 
ATOM   4867 H HE1  . HIS A 1 360 ? 10.593  -25.484 -19.343 1.00 51.03  ? 324 HIS A HE1  1 
ATOM   4868 N N    . GLU A 1 361 ? 5.483   -23.236 -15.365 1.00 37.06  ? 325 GLU A N    1 
ATOM   4869 C CA   . GLU A 1 361 ? 4.319   -23.408 -14.508 1.00 38.27  ? 325 GLU A CA   1 
ATOM   4870 C C    . GLU A 1 361 ? 4.432   -24.777 -13.862 1.00 36.75  ? 325 GLU A C    1 
ATOM   4871 O O    . GLU A 1 361 ? 4.514   -25.792 -14.561 1.00 32.33  ? 325 GLU A O    1 
ATOM   4872 C CB   . GLU A 1 361 ? 3.007   -23.277 -15.278 1.00 42.73  ? 325 GLU A CB   1 
ATOM   4873 C CG   . GLU A 1 361 ? 1.764   -23.265 -14.384 1.00 41.28  ? 325 GLU A CG   1 
ATOM   4874 C CD   . GLU A 1 361 ? 1.507   -21.918 -13.711 1.00 45.74  ? 325 GLU A CD   1 
ATOM   4875 O OE1  . GLU A 1 361 ? 2.402   -21.437 -12.981 1.00 39.83  ? 325 GLU A OE1  1 
ATOM   4876 O OE2  . GLU A 1 361 ? 0.407   -21.341 -13.897 1.00 45.71  ? 325 GLU A OE2  1 
ATOM   4877 H H    . GLU A 1 361 ? 5.405   -23.597 -16.141 1.00 44.46  ? 325 GLU A H    1 
ATOM   4878 H HA   . GLU A 1 361 ? 4.310   -22.718 -13.826 1.00 45.92  ? 325 GLU A HA   1 
ATOM   4879 H HB2  . GLU A 1 361 ? 3.021   -22.445 -15.777 1.00 51.27  ? 325 GLU A HB2  1 
ATOM   4880 H HB3  . GLU A 1 361 ? 2.927   -24.028 -15.887 1.00 51.27  ? 325 GLU A HB3  1 
ATOM   4881 H HG2  . GLU A 1 361 ? 0.988   -23.479 -14.925 1.00 49.53  ? 325 GLU A HG2  1 
ATOM   4882 H HG3  . GLU A 1 361 ? 1.875   -23.929 -13.685 1.00 49.53  ? 325 GLU A HG3  1 
ATOM   4883 N N    . PHE A 1 362 ? 4.489   -24.793 -12.536 1.00 34.14  ? 326 PHE A N    1 
ATOM   4884 C CA   . PHE A 1 362 ? 4.358   -26.021 -11.763 1.00 32.83  ? 326 PHE A CA   1 
ATOM   4885 C C    . PHE A 1 362 ? 2.967   -25.948 -11.158 1.00 30.23  ? 326 PHE A C    1 
ATOM   4886 O O    . PHE A 1 362 ? 2.733   -25.154 -10.237 1.00 28.50  ? 326 PHE A O    1 
ATOM   4887 C CB   . PHE A 1 362 ? 5.443   -26.126 -10.690 1.00 32.97  ? 326 PHE A CB   1 
ATOM   4888 C CG   . PHE A 1 362 ? 6.831   -25.901 -11.230 1.00 31.84  ? 326 PHE A CG   1 
ATOM   4889 C CD1  . PHE A 1 362 ? 7.553   -26.955 -11.759 1.00 32.20  ? 326 PHE A CD1  1 
ATOM   4890 C CD2  . PHE A 1 362 ? 7.400   -24.639 -11.240 1.00 27.90  ? 326 PHE A CD2  1 
ATOM   4891 C CE1  . PHE A 1 362 ? 8.821   -26.758 -12.271 1.00 35.30  ? 326 PHE A CE1  1 
ATOM   4892 C CE2  . PHE A 1 362 ? 8.665   -24.435 -11.752 1.00 30.56  ? 326 PHE A CE2  1 
ATOM   4893 C CZ   . PHE A 1 362 ? 9.378   -25.498 -12.277 1.00 30.24  ? 326 PHE A CZ   1 
ATOM   4894 H H    . PHE A 1 362 ? 4.606   -24.091 -12.052 1.00 40.96  ? 326 PHE A H    1 
ATOM   4895 H HA   . PHE A 1 362 ? 4.461   -26.814 -12.312 1.00 39.38  ? 326 PHE A HA   1 
ATOM   4896 H HB2  . PHE A 1 362 ? 5.276   -25.458 -10.007 1.00 39.55  ? 326 PHE A HB2  1 
ATOM   4897 H HB3  . PHE A 1 362 ? 5.414   -27.014 -10.299 1.00 39.55  ? 326 PHE A HB3  1 
ATOM   4898 H HD1  . PHE A 1 362 ? 7.181   -27.807 -11.771 1.00 38.63  ? 326 PHE A HD1  1 
ATOM   4899 H HD2  . PHE A 1 362 ? 6.923   -23.918 -10.897 1.00 33.47  ? 326 PHE A HD2  1 
ATOM   4900 H HE1  . PHE A 1 362 ? 9.300   -27.478 -12.613 1.00 42.35  ? 326 PHE A HE1  1 
ATOM   4901 H HE2  . PHE A 1 362 ? 9.039   -23.583 -11.745 1.00 36.66  ? 326 PHE A HE2  1 
ATOM   4902 H HZ   . PHE A 1 362 ? 10.228  -25.363 -12.630 1.00 36.28  ? 326 PHE A HZ   1 
ATOM   4903 N N    . PRO A 1 363 ? 1.985   -26.686 -11.684 1.00 32.92  ? 327 PRO A N    1 
ATOM   4904 C CA   . PRO A 1 363 ? 0.597   -26.387 -11.309 1.00 31.20  ? 327 PRO A CA   1 
ATOM   4905 C C    . PRO A 1 363 ? 0.321   -26.580 -9.838  1.00 23.55  ? 327 PRO A C    1 
ATOM   4906 O O    . PRO A 1 363 ? -0.593  -25.947 -9.300  1.00 25.04  ? 327 PRO A O    1 
ATOM   4907 C CB   . PRO A 1 363 ? -0.222  -27.362 -12.170 1.00 35.44  ? 327 PRO A CB   1 
ATOM   4908 C CG   . PRO A 1 363 ? 0.692   -28.497 -12.434 1.00 37.44  ? 327 PRO A CG   1 
ATOM   4909 C CD   . PRO A 1 363 ? 2.085   -27.885 -12.535 1.00 36.11  ? 327 PRO A CD   1 
ATOM   4910 H HA   . PRO A 1 363 ? 0.376   -25.477 -11.563 1.00 37.43  ? 327 PRO A HA   1 
ATOM   4911 H HB2  . PRO A 1 363 ? -1.007  -27.655 -11.681 1.00 42.52  ? 327 PRO A HB2  1 
ATOM   4912 H HB3  . PRO A 1 363 ? -0.489  -26.930 -12.996 1.00 42.52  ? 327 PRO A HB3  1 
ATOM   4913 H HG2  . PRO A 1 363 ? 0.647   -29.132 -11.703 1.00 44.91  ? 327 PRO A HG2  1 
ATOM   4914 H HG3  . PRO A 1 363 ? 0.445   -28.930 -13.266 1.00 44.91  ? 327 PRO A HG3  1 
ATOM   4915 H HD2  . PRO A 1 363 ? 2.757   -28.496 -12.194 1.00 43.32  ? 327 PRO A HD2  1 
ATOM   4916 H HD3  . PRO A 1 363 ? 2.292   -27.643 -13.451 1.00 43.32  ? 327 PRO A HD3  1 
ATOM   4917 N N    . GLU A 1 364 ? 1.082   -27.450 -9.180  1.00 21.87  ? 328 GLU A N    1 
ATOM   4918 C CA   . GLU A 1 364 ? 0.896   -27.658 -7.749  1.00 23.30  ? 328 GLU A CA   1 
ATOM   4919 C C    . GLU A 1 364 ? 0.989   -26.340 -6.997  1.00 25.10  ? 328 GLU A C    1 
ATOM   4920 O O    . GLU A 1 364 ? 0.288   -26.132 -6.000  1.00 22.73  ? 328 GLU A O    1 
ATOM   4921 C CB   . GLU A 1 364 ? 1.952   -28.630 -7.228  1.00 26.72  ? 328 GLU A CB   1 
ATOM   4922 C CG   . GLU A 1 364 ? 1.775   -30.049 -7.678  1.00 28.51  ? 328 GLU A CG   1 
ATOM   4923 C CD   . GLU A 1 364 ? 2.339   -30.330 -9.058  1.00 32.11  ? 328 GLU A CD   1 
ATOM   4924 O OE1  . GLU A 1 364 ? 2.844   -29.401 -9.734  1.00 27.49  ? 328 GLU A OE1  1 
ATOM   4925 O OE2  . GLU A 1 364 ? 2.262   -31.501 -9.482  1.00 29.39  ? 328 GLU A OE2  1 
ATOM   4926 H H    . GLU A 1 364 ? 1.705   -27.926 -9.534  1.00 26.24  ? 328 GLU A H    1 
ATOM   4927 H HA   . GLU A 1 364 ? 0.019   -28.043 -7.594  1.00 27.95  ? 328 GLU A HA   1 
ATOM   4928 H HB2  . GLU A 1 364 ? 2.823   -28.332 -7.536  1.00 32.05  ? 328 GLU A HB2  1 
ATOM   4929 H HB3  . GLU A 1 364 ? 1.923   -28.625 -6.258  1.00 32.05  ? 328 GLU A HB3  1 
ATOM   4930 H HG2  . GLU A 1 364 ? 2.226   -30.634 -7.050  1.00 34.20  ? 328 GLU A HG2  1 
ATOM   4931 H HG3  . GLU A 1 364 ? 0.827   -30.253 -7.700  1.00 34.20  ? 328 GLU A HG3  1 
ATOM   4932 N N    . LEU A 1 365 ? 1.891   -25.461 -7.435  1.00 25.59  ? 329 LEU A N    1 
ATOM   4933 C CA   . LEU A 1 365 ? 2.152   -24.213 -6.727  1.00 21.95  ? 329 LEU A CA   1 
ATOM   4934 C C    . LEU A 1 365 ? 1.018   -23.216 -6.835  1.00 25.39  ? 329 LEU A C    1 
ATOM   4935 O O    . LEU A 1 365 ? 0.978   -22.264 -6.051  1.00 26.51  ? 329 LEU A O    1 
ATOM   4936 C CB   . LEU A 1 365 ? 3.442   -23.598 -7.261  1.00 27.05  ? 329 LEU A CB   1 
ATOM   4937 C CG   . LEU A 1 365 ? 4.633   -24.544 -7.241  1.00 25.10  ? 329 LEU A CG   1 
ATOM   4938 C CD1  . LEU A 1 365 ? 5.857   -23.852 -7.786  1.00 26.87  ? 329 LEU A CD1  1 
ATOM   4939 C CD2  . LEU A 1 365 ? 4.924   -25.090 -5.856  1.00 25.79  ? 329 LEU A CD2  1 
ATOM   4940 H H    . LEU A 1 365 ? 2.367   -25.566 -8.143  1.00 30.70  ? 329 LEU A H    1 
ATOM   4941 H HA   . LEU A 1 365 ? 2.268   -24.403 -5.783  1.00 26.33  ? 329 LEU A HA   1 
ATOM   4942 H HB2  . LEU A 1 365 ? 3.298   -23.324 -8.180  1.00 32.45  ? 329 LEU A HB2  1 
ATOM   4943 H HB3  . LEU A 1 365 ? 3.668   -22.828 -6.716  1.00 32.45  ? 329 LEU A HB3  1 
ATOM   4944 H HG   . LEU A 1 365 ? 4.410   -25.303 -7.802  1.00 30.11  ? 329 LEU A HG   1 
ATOM   4945 H HD11 . LEU A 1 365 ? 6.580   -24.496 -7.854  1.00 32.23  ? 329 LEU A HD11 1 
ATOM   4946 H HD12 . LEU A 1 365 ? 5.652   -23.492 -8.663  1.00 32.23  ? 329 LEU A HD12 1 
ATOM   4947 H HD13 . LEU A 1 365 ? 6.109   -23.135 -7.184  1.00 32.23  ? 329 LEU A HD13 1 
ATOM   4948 H HD21 . LEU A 1 365 ? 5.774   -25.556 -5.873  1.00 30.94  ? 329 LEU A HD21 1 
ATOM   4949 H HD22 . LEU A 1 365 ? 4.964   -24.352 -5.227  1.00 30.94  ? 329 LEU A HD22 1 
ATOM   4950 H HD23 . LEU A 1 365 ? 4.215   -25.702 -5.602  1.00 30.94  ? 329 LEU A HD23 1 
ATOM   4951 N N    . ARG A 1 366 ? 0.086   -23.423 -7.756  1.00 26.76  ? 330 ARG A N    1 
ATOM   4952 C CA   . ARG A 1 366 ? -1.034  -22.523 -7.960  1.00 25.21  ? 330 ARG A CA   1 
ATOM   4953 C C    . ARG A 1 366 ? -2.340  -23.051 -7.381  1.00 28.66  ? 330 ARG A C    1 
ATOM   4954 O O    . ARG A 1 366 ? -3.354  -22.339 -7.411  1.00 29.10  ? 330 ARG A O    1 
ATOM   4955 C CB   . ARG A 1 366 ? -1.194  -22.268 -9.457  1.00 29.47  ? 330 ARG A CB   1 
ATOM   4956 C CG   . ARG A 1 366 ? 0.103   -21.875 -10.155 1.00 33.56  ? 330 ARG A CG   1 
ATOM   4957 C CD   . ARG A 1 366 ? 0.574   -20.512 -9.666  1.00 35.08  ? 330 ARG A CD   1 
ATOM   4958 N NE   . ARG A 1 366 ? -0.262  -19.426 -10.165 1.00 37.07  ? 330 ARG A NE   1 
ATOM   4959 C CZ   . ARG A 1 366 ? -0.458  -18.268 -9.544  1.00 43.35  ? 330 ARG A CZ   1 
ATOM   4960 N NH1  . ARG A 1 366 ? 0.075   -18.015 -8.351  1.00 34.61  ? 330 ARG A NH1  1 
ATOM   4961 N NH2  . ARG A 1 366 ? -1.193  -17.331 -10.141 1.00 41.09  ? 330 ARG A NH2  1 
ATOM   4962 H H    . ARG A 1 366 ? 0.083   -24.098 -8.289  1.00 32.10  ? 330 ARG A H    1 
ATOM   4963 H HA   . ARG A 1 366 ? -0.853  -21.678 -7.518  1.00 30.24  ? 330 ARG A HA   1 
ATOM   4964 H HB2  . ARG A 1 366 ? -1.523  -23.078 -9.878  1.00 35.36  ? 330 ARG A HB2  1 
ATOM   4965 H HB3  . ARG A 1 366 ? -1.829  -21.546 -9.585  1.00 35.36  ? 330 ARG A HB3  1 
ATOM   4966 H HG2  . ARG A 1 366 ? 0.791   -22.530 -9.957  1.00 40.27  ? 330 ARG A HG2  1 
ATOM   4967 H HG3  . ARG A 1 366 ? -0.044  -21.827 -11.113 1.00 40.27  ? 330 ARG A HG3  1 
ATOM   4968 H HD2  . ARG A 1 366 ? 0.545   -20.494 -8.697  1.00 42.09  ? 330 ARG A HD2  1 
ATOM   4969 H HD3  . ARG A 1 366 ? 1.482   -20.360 -9.973  1.00 42.09  ? 330 ARG A HD3  1 
ATOM   4970 H HE   . ARG A 1 366 ? -0.658  -19.544 -10.920 1.00 44.48  ? 330 ARG A HE   1 
ATOM   4971 H HH11 . ARG A 1 366 ? 0.561   -18.609 -7.962  1.00 41.52  ? 330 ARG A HH11 1 
ATOM   4972 H HH12 . ARG A 1 366 ? -0.066  -17.258 -7.968  1.00 41.52  ? 330 ARG A HH12 1 
ATOM   4973 H HH21 . ARG A 1 366 ? -1.533  -17.480 -10.917 1.00 49.29  ? 330 ARG A HH21 1 
ATOM   4974 H HH22 . ARG A 1 366 ? -1.329  -16.577 -9.750  1.00 49.29  ? 330 ARG A HH22 1 
ATOM   4975 N N    . LYS A 1 367 ? -2.341  -24.261 -6.838  1.00 25.92  ? 331 LYS A N    1 
ATOM   4976 C CA   . LYS A 1 367 ? -3.558  -24.821 -6.282  1.00 29.01  ? 331 LYS A CA   1 
ATOM   4977 C C    . LYS A 1 367 ? -3.846  -24.254 -4.905  1.00 26.12  ? 331 LYS A C    1 
ATOM   4978 O O    . LYS A 1 367 ? -2.942  -23.923 -4.130  1.00 25.38  ? 331 LYS A O    1 
ATOM   4979 C CB   . LYS A 1 367 ? -3.462  -26.342 -6.222  1.00 26.24  ? 331 LYS A CB   1 
ATOM   4980 C CG   . LYS A 1 367 ? -3.592  -26.968 -7.590  1.00 30.74  ? 331 LYS A CG   1 
ATOM   4981 C CD   . LYS A 1 367 ? -3.423  -28.475 -7.562  1.00 34.77  ? 331 LYS A CD   1 
ATOM   4982 C CE   . LYS A 1 367 ? -3.575  -29.056 -8.965  1.00 39.59  ? 331 LYS A CE   1 
ATOM   4983 N NZ   . LYS A 1 367 ? -4.329  -30.335 -8.903  1.00 48.10  ? 331 LYS A NZ   1 
ATOM   4984 H H    . LYS A 1 367 ? -1.653  -24.774 -6.781  1.00 31.09  ? 331 LYS A H    1 
ATOM   4985 H HA   . LYS A 1 367 ? -4.308  -24.588 -6.853  1.00 34.81  ? 331 LYS A HA   1 
ATOM   4986 H HB2  . LYS A 1 367 ? -2.601  -26.592 -5.853  1.00 31.47  ? 331 LYS A HB2  1 
ATOM   4987 H HB3  . LYS A 1 367 ? -4.175  -26.685 -5.661  1.00 31.47  ? 331 LYS A HB3  1 
ATOM   4988 H HG2  . LYS A 1 367 ? -4.472  -26.771 -7.946  1.00 36.88  ? 331 LYS A HG2  1 
ATOM   4989 H HG3  . LYS A 1 367 ? -2.908  -26.601 -8.172  1.00 36.88  ? 331 LYS A HG3  1 
ATOM   4990 H HD2  . LYS A 1 367 ? -2.540  -28.697 -7.230  1.00 41.71  ? 331 LYS A HD2  1 
ATOM   4991 H HD3  . LYS A 1 367 ? -4.101  -28.868 -6.990  1.00 41.71  ? 331 LYS A HD3  1 
ATOM   4992 H HE2  . LYS A 1 367 ? -4.063  -28.433 -9.526  1.00 47.50  ? 331 LYS A HE2  1 
ATOM   4993 H HE3  . LYS A 1 367 ? -2.699  -29.229 -9.345  1.00 47.50  ? 331 LYS A HE3  1 
ATOM   4994 H HZ1  . LYS A 1 367 ? -4.313  -30.737 -9.697  1.00 57.71  ? 331 LYS A HZ1  1 
ATOM   4995 H HZ2  . LYS A 1 367 ? -3.962  -30.876 -8.299  1.00 57.71  ? 331 LYS A HZ2  1 
ATOM   4996 H HZ3  . LYS A 1 367 ? -5.175  -30.179 -8.675  1.00 57.71  ? 331 LYS A HZ3  1 
ATOM   4997 N N    . ALA A 1 368 ? -5.129  -24.143 -4.604  1.00 19.97  ? 332 ALA A N    1 
ATOM   4998 C CA   . ALA A 1 368 ? -5.533  -23.643 -3.308  1.00 22.81  ? 332 ALA A CA   1 
ATOM   4999 C C    . ALA A 1 368 ? -4.954  -24.508 -2.197  1.00 26.23  ? 332 ALA A C    1 
ATOM   5000 O O    . ALA A 1 368 ? -5.042  -25.738 -2.230  1.00 22.66  ? 332 ALA A O    1 
ATOM   5001 C CB   . ALA A 1 368 ? -7.052  -23.594 -3.200  1.00 27.47  ? 332 ALA A CB   1 
ATOM   5002 H H    . ALA A 1 368 ? -5.778  -24.348 -5.129  1.00 23.95  ? 332 ALA A H    1 
ATOM   5003 H HA   . ALA A 1 368 ? -5.196  -22.739 -3.201  1.00 27.37  ? 332 ALA A HA   1 
ATOM   5004 H HB1  . ALA A 1 368 ? -7.296  -23.312 -2.305  1.00 32.95  ? 332 ALA A HB1  1 
ATOM   5005 H HB2  . ALA A 1 368 ? -7.394  -22.961 -3.851  1.00 32.95  ? 332 ALA A HB2  1 
ATOM   5006 H HB3  . ALA A 1 368 ? -7.410  -24.477 -3.378  1.00 32.95  ? 332 ALA A HB3  1 
ATOM   5007 N N    . LEU A 1 369 ? -4.406  -23.843 -1.185  1.00 24.30  ? 333 LEU A N    1 
ATOM   5008 C CA   . LEU A 1 369 ? -3.765  -24.511 -0.064  1.00 20.51  ? 333 LEU A CA   1 
ATOM   5009 C C    . LEU A 1 369 ? -4.498  -24.209 1.230   1.00 19.82  ? 333 LEU A C    1 
ATOM   5010 O O    . LEU A 1 369 ? -5.048  -25.111 1.875   1.00 21.67  ? 333 LEU A O    1 
ATOM   5011 C CB   . LEU A 1 369 ? -2.310  -24.027 0.008   1.00 20.20  ? 333 LEU A CB   1 
ATOM   5012 C CG   . LEU A 1 369 ? -1.478  -24.454 1.211   1.00 19.35  ? 333 LEU A CG   1 
ATOM   5013 C CD1  . LEU A 1 369 ? -1.272  -25.931 1.171   1.00 17.94  ? 333 LEU A CD1  1 
ATOM   5014 C CD2  . LEU A 1 369 ? -0.125  -23.730 1.190   1.00 18.81  ? 333 LEU A CD2  1 
ATOM   5015 H H    . LEU A 1 369 ? -4.394  -22.985 -1.126  1.00 29.15  ? 333 LEU A H    1 
ATOM   5016 H HA   . LEU A 1 369 ? -3.772  -25.473 -0.189  1.00 24.60  ? 333 LEU A HA   1 
ATOM   5017 H HB2  . LEU A 1 369 ? -1.850  -24.356 -0.781  1.00 24.23  ? 333 LEU A HB2  1 
ATOM   5018 H HB3  . LEU A 1 369 ? -2.320  -23.057 0.005   1.00 24.23  ? 333 LEU A HB3  1 
ATOM   5019 H HG   . LEU A 1 369 ? -1.939  -24.223 2.033   1.00 23.20  ? 333 LEU A HG   1 
ATOM   5020 H HD11 . LEU A 1 369 ? -0.759  -26.199 1.950   1.00 21.52  ? 333 LEU A HD11 1 
ATOM   5021 H HD12 . LEU A 1 369 ? -2.136  -26.371 1.177   1.00 21.52  ? 333 LEU A HD12 1 
ATOM   5022 H HD13 . LEU A 1 369 ? -0.789  -26.160 0.362   1.00 21.52  ? 333 LEU A HD13 1 
ATOM   5023 H HD21 . LEU A 1 369 ? 0.399   -24.019 1.954   1.00 22.57  ? 333 LEU A HD21 1 
ATOM   5024 H HD22 . LEU A 1 369 ? 0.339   -23.952 0.368   1.00 22.57  ? 333 LEU A HD22 1 
ATOM   5025 H HD23 . LEU A 1 369 ? -0.278  -22.773 1.236   1.00 22.57  ? 333 LEU A HD23 1 
ATOM   5026 N N    . GLY A 1 370 ? -4.584  -22.933 1.585   1.00 18.17  ? 334 GLY A N    1 
ATOM   5027 C CA   . GLY A 1 370 ? -5.255  -22.493 2.770   1.00 16.39  ? 334 GLY A CA   1 
ATOM   5028 C C    . GLY A 1 370 ? -4.428  -22.705 4.012   1.00 18.79  ? 334 GLY A C    1 
ATOM   5029 O O    . GLY A 1 370 ? -3.394  -23.377 3.991   1.00 18.46  ? 334 GLY A O    1 
ATOM   5030 H H    . GLY A 1 370 ? -4.245  -22.287 1.130   1.00 21.79  ? 334 GLY A H    1 
ATOM   5031 H HA2  . GLY A 1 370 ? -5.454  -21.547 2.694   1.00 19.66  ? 334 GLY A HA2  1 
ATOM   5032 H HA3  . GLY A 1 370 ? -6.086  -22.984 2.869   1.00 19.66  ? 334 GLY A HA3  1 
ATOM   5033 N N    . PRO A 1 371 ? -4.894  -22.158 5.123   1.00 18.22  ? 335 PRO A N    1 
ATOM   5034 C CA   . PRO A 1 371 ? -4.107  -22.211 6.355   1.00 20.18  ? 335 PRO A CA   1 
ATOM   5035 C C    . PRO A 1 371 ? -3.928  -23.643 6.824   1.00 21.15  ? 335 PRO A C    1 
ATOM   5036 O O    . PRO A 1 371 ? -4.816  -24.497 6.635   1.00 17.81  ? 335 PRO A O    1 
ATOM   5037 C CB   . PRO A 1 371 ? -4.943  -21.403 7.353   1.00 23.18  ? 335 PRO A CB   1 
ATOM   5038 C CG   . PRO A 1 371 ? -5.833  -20.559 6.541   1.00 25.61  ? 335 PRO A CG   1 
ATOM   5039 C CD   . PRO A 1 371 ? -6.077  -21.279 5.254   1.00 20.59  ? 335 PRO A CD   1 
ATOM   5040 H HA   . PRO A 1 371 ? -3.242  -21.792 6.225   1.00 24.20  ? 335 PRO A HA   1 
ATOM   5041 H HB2  . PRO A 1 371 ? -5.457  -22.005 7.913   1.00 27.81  ? 335 PRO A HB2  1 
ATOM   5042 H HB3  . PRO A 1 371 ? -4.358  -20.857 7.902   1.00 27.81  ? 335 PRO A HB3  1 
ATOM   5043 H HG2  . PRO A 1 371 ? -6.667  -20.422 7.016   1.00 30.72  ? 335 PRO A HG2  1 
ATOM   5044 H HG3  . PRO A 1 371 ? -5.402  -19.705 6.375   1.00 30.72  ? 335 PRO A HG3  1 
ATOM   5045 H HD2  . PRO A 1 371 ? -6.893  -21.802 5.301   1.00 24.70  ? 335 PRO A HD2  1 
ATOM   5046 H HD3  . PRO A 1 371 ? -6.127  -20.654 4.513   1.00 24.70  ? 335 PRO A HD3  1 
ATOM   5047 N N    . PRO A 1 372 ? -2.798  -23.948 7.450   1.00 21.32  ? 336 PRO A N    1 
ATOM   5048 C CA   . PRO A 1 372 ? -2.648  -25.267 8.075   1.00 20.02  ? 336 PRO A CA   1 
ATOM   5049 C C    . PRO A 1 372 ? -3.647  -25.428 9.215   1.00 20.96  ? 336 PRO A C    1 
ATOM   5050 O O    . PRO A 1 372 ? -3.954  -24.482 9.947   1.00 23.96  ? 336 PRO A O    1 
ATOM   5051 C CB   . PRO A 1 372 ? -1.200  -25.285 8.584   1.00 19.82  ? 336 PRO A CB   1 
ATOM   5052 C CG   . PRO A 1 372 ? -0.797  -23.854 8.661   1.00 19.77  ? 336 PRO A CG   1 
ATOM   5053 C CD   . PRO A 1 372 ? -1.621  -23.089 7.652   1.00 20.01  ? 336 PRO A CD   1 
ATOM   5054 H HA   . PRO A 1 372 ? -2.758  -25.975 7.422   1.00 24.01  ? 336 PRO A HA   1 
ATOM   5055 H HB2  . PRO A 1 372 ? -1.163  -25.703 9.459   1.00 23.77  ? 336 PRO A HB2  1 
ATOM   5056 H HB3  . PRO A 1 372 ? -0.637  -25.770 7.961   1.00 23.77  ? 336 PRO A HB3  1 
ATOM   5057 H HG2  . PRO A 1 372 ? -0.968  -23.522 9.556   1.00 23.71  ? 336 PRO A HG2  1 
ATOM   5058 H HG3  . PRO A 1 372 ? 0.147   -23.777 8.453   1.00 23.71  ? 336 PRO A HG3  1 
ATOM   5059 H HD2  . PRO A 1 372 ? -1.881  -22.224 8.005   1.00 24.00  ? 336 PRO A HD2  1 
ATOM   5060 H HD3  . PRO A 1 372 ? -1.131  -22.975 6.823   1.00 24.00  ? 336 PRO A HD3  1 
ATOM   5061 N N    . LYS A 1 373 ? -4.168  -26.642 9.345   1.00 19.31  ? 337 LYS A N    1 
ATOM   5062 C CA   . LYS A 1 373 ? -5.082  -26.944 10.435  1.00 20.22  ? 337 LYS A CA   1 
ATOM   5063 C C    . LYS A 1 373 ? -4.337  -27.302 11.693  1.00 20.83  ? 337 LYS A C    1 
ATOM   5064 O O    . LYS A 1 373 ? -4.916  -27.266 12.788  1.00 23.03  ? 337 LYS A O    1 
ATOM   5065 C CB   . LYS A 1 373 ? -6.018  -28.084 10.026  1.00 23.75  ? 337 LYS A CB   1 
ATOM   5066 C CG   . LYS A 1 373 ? -6.811  -27.799 8.753   1.00 25.01  ? 337 LYS A CG   1 
ATOM   5067 C CD   . LYS A 1 373 ? -8.028  -28.764 8.614   1.00 33.08  ? 337 LYS A CD   1 
ATOM   5068 C CE   . LYS A 1 373 ? -8.626  -28.805 7.195   1.00 37.04  ? 337 LYS A CE   1 
ATOM   5069 N NZ   . LYS A 1 373 ? -9.549  -29.999 7.025   1.00 43.09  ? 337 LYS A NZ   1 
ATOM   5070 H H    . LYS A 1 373 ? -4.009  -27.303 8.819   1.00 23.17  ? 337 LYS A H    1 
ATOM   5071 H HA   . LYS A 1 373 ? -5.638  -26.172 10.624  1.00 24.26  ? 337 LYS A HA   1 
ATOM   5072 H HB2  . LYS A 1 373 ? -5.490  -28.883 9.874   1.00 28.49  ? 337 LYS A HB2  1 
ATOM   5073 H HB3  . LYS A 1 373 ? -6.654  -28.239 10.743  1.00 28.49  ? 337 LYS A HB3  1 
ATOM   5074 H HG2  . LYS A 1 373 ? -7.145  -26.888 8.779   1.00 30.00  ? 337 LYS A HG2  1 
ATOM   5075 H HG3  . LYS A 1 373 ? -6.236  -27.919 7.981   1.00 30.00  ? 337 LYS A HG3  1 
ATOM   5076 H HD2  . LYS A 1 373 ? -7.742  -29.662 8.841   1.00 39.69  ? 337 LYS A HD2  1 
ATOM   5077 H HD3  . LYS A 1 373 ? -8.728  -28.475 9.220   1.00 39.69  ? 337 LYS A HD3  1 
ATOM   5078 H HE2  . LYS A 1 373 ? -9.137  -27.997 7.036   1.00 44.43  ? 337 LYS A HE2  1 
ATOM   5079 H HE3  . LYS A 1 373 ? -7.909  -28.877 6.545   1.00 44.43  ? 337 LYS A HE3  1 
ATOM   5080 H HZ1  . LYS A 1 373 ? -9.941  -29.969 6.226   1.00 51.70  ? 337 LYS A HZ1  1 
ATOM   5081 H HZ2  . LYS A 1 373 ? -9.085  -30.755 7.091   1.00 51.70  ? 337 LYS A HZ2  1 
ATOM   5082 H HZ3  . LYS A 1 373 ? -10.177 -29.990 7.655   1.00 51.70  ? 337 LYS A HZ3  1 
ATOM   5083 N N    . GLY A 1 374 ? -3.058  -27.636 11.561  1.00 22.02  ? 338 GLY A N    1 
ATOM   5084 C CA   . GLY A 1 374 ? -2.199  -27.816 12.705  1.00 23.53  ? 338 GLY A CA   1 
ATOM   5085 C C    . GLY A 1 374 ? -0.827  -28.208 12.214  1.00 23.08  ? 338 GLY A C    1 
ATOM   5086 O O    . GLY A 1 374 ? -0.560  -28.271 11.007  1.00 18.80  ? 338 GLY A O    1 
ATOM   5087 H H    . GLY A 1 374 ? -2.666  -27.764 10.807  1.00 26.41  ? 338 GLY A H    1 
ATOM   5088 H HA2  . GLY A 1 374 ? -2.135  -26.991 13.211  1.00 28.23  ? 338 GLY A HA2  1 
ATOM   5089 H HA3  . GLY A 1 374 ? -2.547  -28.514 13.281  1.00 28.23  ? 338 GLY A HA3  1 
ATOM   5090 N N    . ALA A 1 375 ? 0.038   -28.447 13.174  1.00 20.04  ? 339 ALA A N    1 
ATOM   5091 C CA   . ALA A 1 375 ? 1.365   -28.965 12.899  1.00 15.54  ? 339 ALA A CA   1 
ATOM   5092 C C    . ALA A 1 375 ? 1.290   -30.324 12.203  1.00 22.01  ? 339 ALA A C    1 
ATOM   5093 O O    . ALA A 1 375 ? 0.267   -31.020 12.214  1.00 20.70  ? 339 ALA A O    1 
ATOM   5094 C CB   . ALA A 1 375 ? 2.148   -29.064 14.204  1.00 23.32  ? 339 ALA A CB   1 
ATOM   5095 H H    . ALA A 1 375 ? -0.117  -28.317 14.010  1.00 24.04  ? 339 ALA A H    1 
ATOM   5096 H HA   . ALA A 1 375 ? 1.839   -28.368 12.300  1.00 18.64  ? 339 ALA A HA   1 
ATOM   5097 H HB1  . ALA A 1 375 ? 3.038   -29.399 14.014  1.00 27.97  ? 339 ALA A HB1  1 
ATOM   5098 H HB2  . ALA A 1 375 ? 2.204   -28.184 14.606  1.00 27.97  ? 339 ALA A HB2  1 
ATOM   5099 H HB3  . ALA A 1 375 ? 1.687   -29.672 14.804  1.00 27.97  ? 339 ALA A HB3  1 
ATOM   5100 N N    . TYR A 1 376 ? 2.399   -30.696 11.566  1.00 19.47  ? 340 TYR A N    1 
ATOM   5101 C CA   . TYR A 1 376 ? 2.496   -32.021 10.979  1.00 20.53  ? 340 TYR A CA   1 
ATOM   5102 C C    . TYR A 1 376 ? 2.407   -33.085 12.057  1.00 22.38  ? 340 TYR A C    1 
ATOM   5103 O O    . TYR A 1 376 ? 2.688   -32.854 13.230  1.00 20.35  ? 340 TYR A O    1 
ATOM   5104 C CB   . TYR A 1 376 ? 3.796   -32.188 10.184  1.00 19.66  ? 340 TYR A CB   1 
ATOM   5105 C CG   . TYR A 1 376 ? 5.075   -32.318 10.976  1.00 16.32  ? 340 TYR A CG   1 
ATOM   5106 C CD1  . TYR A 1 376 ? 5.421   -33.505 11.600  1.00 23.37  ? 340 TYR A CD1  1 
ATOM   5107 C CD2  . TYR A 1 376 ? 5.996   -31.275 11.011  1.00 18.67  ? 340 TYR A CD2  1 
ATOM   5108 C CE1  . TYR A 1 376 ? 6.600   -33.634 12.302  1.00 24.73  ? 340 TYR A CE1  1 
ATOM   5109 C CE2  . TYR A 1 376 ? 7.170   -31.387 11.710  1.00 22.36  ? 340 TYR A CE2  1 
ATOM   5110 C CZ   . TYR A 1 376 ? 7.477   -32.572 12.352  1.00 27.36  ? 340 TYR A CZ   1 
ATOM   5111 O OH   . TYR A 1 376 ? 8.679   -32.685 13.046  1.00 21.91  ? 340 TYR A OH   1 
ATOM   5112 H H    . TYR A 1 376 ? 3.097   -30.204 11.464  1.00 23.36  ? 340 TYR A H    1 
ATOM   5113 H HA   . TYR A 1 376 ? 1.759   -32.143 10.360  1.00 24.62  ? 340 TYR A HA   1 
ATOM   5114 H HB2  . TYR A 1 376 ? 3.715   -32.990 9.645   1.00 23.58  ? 340 TYR A HB2  1 
ATOM   5115 H HB3  . TYR A 1 376 ? 3.897   -31.412 9.611   1.00 23.58  ? 340 TYR A HB3  1 
ATOM   5116 H HD1  . TYR A 1 376 ? 4.844   -34.233 11.545  1.00 28.04  ? 340 TYR A HD1  1 
ATOM   5117 H HD2  . TYR A 1 376 ? 5.812   -30.488 10.551  1.00 22.39  ? 340 TYR A HD2  1 
ATOM   5118 H HE1  . TYR A 1 376 ? 6.802   -34.431 12.738  1.00 29.67  ? 340 TYR A HE1  1 
ATOM   5119 H HE2  . TYR A 1 376 ? 7.757   -30.667 11.753  1.00 26.83  ? 340 TYR A HE2  1 
ATOM   5120 H HH   . TYR A 1 376 ? 9.107   -31.964 12.999  1.00 26.28  ? 340 TYR A HH   1 
ATOM   5121 N N    . ASP A 1 377 ? 2.039   -34.282 11.625  1.00 20.21  ? 341 ASP A N    1 
ATOM   5122 C CA   . ASP A 1 377 ? 2.046   -35.455 12.482  1.00 23.55  ? 341 ASP A CA   1 
ATOM   5123 C C    . ASP A 1 377 ? 3.102   -36.391 11.910  1.00 23.90  ? 341 ASP A C    1 
ATOM   5124 O O    . ASP A 1 377 ? 3.117   -36.640 10.690  1.00 22.42  ? 341 ASP A O    1 
ATOM   5125 C CB   . ASP A 1 377 ? 0.670   -36.118 12.521  1.00 22.44  ? 341 ASP A CB   1 
ATOM   5126 C CG   . ASP A 1 377 ? -0.339  -35.369 13.375  1.00 26.97  ? 341 ASP A CG   1 
ATOM   5127 O OD1  . ASP A 1 377 ? -0.015  -34.831 14.466  1.00 29.05  ? 341 ASP A OD1  1 
ATOM   5128 O OD2  . ASP A 1 377 ? -1.517  -35.380 12.977  1.00 33.94  ? 341 ASP A OD2  1 
ATOM   5129 H H    . ASP A 1 377 ? 1.776   -34.443 10.823  1.00 24.24  ? 341 ASP A H    1 
ATOM   5130 H HA   . ASP A 1 377 ? 2.267   -35.233 13.400  1.00 28.25  ? 341 ASP A HA   1 
ATOM   5131 H HB2  . ASP A 1 377 ? 0.319   -36.163 11.618  1.00 26.92  ? 341 ASP A HB2  1 
ATOM   5132 H HB3  . ASP A 1 377 ? 0.763   -37.011 12.887  1.00 26.92  ? 341 ASP A HB3  1 
ATOM   5133 N N    . ARG A 1 378 ? 4.042   -36.807 12.762  1.00 32.08  ? 342 ARG A N    1 
ATOM   5134 C CA   . ARG A 1 378 ? 4.991   -37.872 12.427  1.00 33.35  ? 342 ARG A CA   1 
ATOM   5135 C C    . ARG A 1 378 ? 4.284   -39.189 12.692  1.00 26.41  ? 342 ARG A C    1 
ATOM   5136 O O    . ARG A 1 378 ? 4.117   -39.566 13.859  1.00 34.16  ? 342 ARG A O    1 
ATOM   5137 C CB   . ARG A 1 378 ? 6.248   -37.773 13.272  1.00 31.30  ? 342 ARG A CB   1 
ATOM   5138 C CG   . ARG A 1 378 ? 7.331   -38.757 12.898  1.00 36.23  ? 342 ARG A CG   1 
ATOM   5139 C CD   . ARG A 1 378 ? 8.602   -38.503 13.716  1.00 27.29  ? 342 ARG A CD   1 
ATOM   5140 N NE   . ARG A 1 378 ? 9.738   -39.217 13.149  1.00 33.86  ? 342 ARG A NE   1 
ATOM   5141 C CZ   . ARG A 1 378 ? 11.004  -39.012 13.506  1.00 41.79  ? 342 ARG A CZ   1 
ATOM   5142 N NH1  . ARG A 1 378 ? 11.320  -38.177 14.480  1.00 37.75  ? 342 ARG A NH1  1 
ATOM   5143 N NH2  . ARG A 1 378 ? 11.977  -39.651 12.862  1.00 35.57  ? 342 ARG A NH2  1 
ATOM   5144 H H    . ARG A 1 378 ? 4.152   -36.484 13.551  1.00 38.48  ? 342 ARG A H    1 
ATOM   5145 H HA   . ARG A 1 378 ? 5.254   -37.802 11.496  1.00 40.01  ? 342 ARG A HA   1 
ATOM   5146 H HB2  . ARG A 1 378 ? 6.616   -36.881 13.174  1.00 37.55  ? 342 ARG A HB2  1 
ATOM   5147 H HB3  . ARG A 1 378 ? 6.011   -37.935 14.198  1.00 37.55  ? 342 ARG A HB3  1 
ATOM   5148 H HG2  . ARG A 1 378 ? 7.025   -39.660 13.078  1.00 43.47  ? 342 ARG A HG2  1 
ATOM   5149 H HG3  . ARG A 1 378 ? 7.546   -38.661 11.957  1.00 43.47  ? 342 ARG A HG3  1 
ATOM   5150 H HD2  . ARG A 1 378 ? 8.804   -37.554 13.713  1.00 32.74  ? 342 ARG A HD2  1 
ATOM   5151 H HD3  . ARG A 1 378 ? 8.468   -38.810 14.626  1.00 32.74  ? 342 ARG A HD3  1 
ATOM   5152 H HE   . ARG A 1 378 ? 9.581   -39.810 12.546  1.00 40.62  ? 342 ARG A HE   1 
ATOM   5153 H HH11 . ARG A 1 378 ? 10.701  -37.751 14.899  1.00 45.29  ? 342 ARG A HH11 1 
ATOM   5154 H HH12 . ARG A 1 378 ? 12.144  -38.059 14.695  1.00 45.29  ? 342 ARG A HH12 1 
ATOM   5155 H HH21 . ARG A 1 378 ? 11.785  -40.191 12.221  1.00 42.68  ? 342 ARG A HH21 1 
ATOM   5156 H HH22 . ARG A 1 378 ? 12.797  -39.524 13.087  1.00 42.68  ? 342 ARG A HH22 1 
ATOM   5157 N N    . THR A 1 379 ? 3.874   -39.879 11.621  1.00 37.02  ? 343 THR A N    1 
ATOM   5158 C CA   . THR A 1 379 ? 2.904   -40.959 11.766  1.00 31.36  ? 343 THR A CA   1 
ATOM   5159 C C    . THR A 1 379 ? 3.403   -42.054 12.714  1.00 37.85  ? 343 THR A C    1 
ATOM   5160 O O    . THR A 1 379 ? 2.591   -42.684 13.397  1.00 43.02  ? 343 THR A O    1 
ATOM   5161 C CB   . THR A 1 379 ? 2.525   -41.568 10.408  1.00 38.62  ? 343 THR A CB   1 
ATOM   5162 O OG1  . THR A 1 379 ? 3.502   -42.532 9.996   1.00 48.80  ? 343 THR A OG1  1 
ATOM   5163 C CG2  . THR A 1 379 ? 2.400   -40.530 9.332   1.00 35.30  ? 343 THR A CG2  1 
ATOM   5164 H H    . THR A 1 379 ? 4.140   -39.742 10.815  1.00 44.41  ? 343 THR A H    1 
ATOM   5165 H HA   . THR A 1 379 ? 2.096   -40.573 12.141  1.00 37.62  ? 343 THR A HA   1 
ATOM   5166 H HB   . THR A 1 379 ? 1.661   -41.996 10.517  1.00 46.34  ? 343 THR A HB   1 
ATOM   5167 H HG1  . THR A 1 379 ? 3.286   -42.859 9.253   1.00 58.54  ? 343 THR A HG1  1 
ATOM   5168 H HG21 . THR A 1 379 ? 2.135   -40.948 8.498   1.00 42.35  ? 343 THR A HG21 1 
ATOM   5169 H HG22 . THR A 1 379 ? 1.732   -39.873 9.581   1.00 42.35  ? 343 THR A HG22 1 
ATOM   5170 H HG23 . THR A 1 379 ? 3.250   -40.082 9.203   1.00 42.35  ? 343 THR A HG23 1 
ATOM   5171 N N    . THR A 1 380 ? 4.716   -42.297 12.786  1.00 31.66  ? 344 THR A N    1 
ATOM   5172 C CA   . THR A 1 380 ? 5.255   -43.124 13.853  1.00 32.38  ? 344 THR A CA   1 
ATOM   5173 C C    . THR A 1 380 ? 6.490   -42.474 14.459  1.00 43.76  ? 344 THR A C    1 
ATOM   5174 O O    . THR A 1 380 ? 7.236   -41.777 13.756  1.00 40.65  ? 344 THR A O    1 
ATOM   5175 C CB   . THR A 1 380 ? 5.614   -44.535 13.348  1.00 40.75  ? 344 THR A CB   1 
ATOM   5176 O OG1  . THR A 1 380 ? 6.911   -44.527 12.728  1.00 41.27  ? 344 THR A OG1  1 
ATOM   5177 C CG2  . THR A 1 380 ? 4.609   -45.003 12.307  1.00 42.67  ? 344 THR A CG2  1 
ATOM   5178 H H    . THR A 1 380 ? 5.300   -41.994 12.233  1.00 37.98  ? 344 THR A H    1 
ATOM   5179 H HA   . THR A 1 380 ? 4.587   -43.212 14.550  1.00 38.84  ? 344 THR A HA   1 
ATOM   5180 H HB   . THR A 1 380 ? 5.608   -45.142 14.105  1.00 48.89  ? 344 THR A HB   1 
ATOM   5181 H HG1  . THR A 1 380 ? 7.053   -45.264 12.350  1.00 49.51  ? 344 THR A HG1  1 
ATOM   5182 H HG21 . THR A 1 380 ? 4.724   -45.951 12.137  1.00 51.20  ? 344 THR A HG21 1 
ATOM   5183 H HG22 . THR A 1 380 ? 3.706   -44.847 12.624  1.00 51.20  ? 344 THR A HG22 1 
ATOM   5184 H HG23 . THR A 1 380 ? 4.740   -44.516 11.478  1.00 51.20  ? 344 THR A HG23 1 
ATOM   5185 N N    . PRO A 1 381 ? 6.752   -42.714 15.757  1.00 41.18  ? 345 PRO A N    1 
ATOM   5186 C CA   . PRO A 1 381 ? 7.724   -41.876 16.473  1.00 38.17  ? 345 PRO A CA   1 
ATOM   5187 C C    . PRO A 1 381 ? 9.119   -41.908 15.889  1.00 46.51  ? 345 PRO A C    1 
ATOM   5188 O O    . PRO A 1 381 ? 9.839   -40.902 15.979  1.00 40.73  ? 345 PRO A O    1 
ATOM   5189 C CB   . PRO A 1 381 ? 7.697   -42.462 17.893  1.00 39.65  ? 345 PRO A CB   1 
ATOM   5190 C CG   . PRO A 1 381 ? 6.328   -42.967 18.043  1.00 35.51  ? 345 PRO A CG   1 
ATOM   5191 C CD   . PRO A 1 381 ? 6.072   -43.634 16.691  1.00 43.59  ? 345 PRO A CD   1 
ATOM   5192 H HA   . PRO A 1 381 ? 7.413   -40.958 16.487  1.00 45.79  ? 345 PRO A HA   1 
ATOM   5193 H HB2  . PRO A 1 381 ? 8.346   -43.179 17.972  1.00 47.57  ? 345 PRO A HB2  1 
ATOM   5194 H HB3  . PRO A 1 381 ? 7.888   -41.769 18.544  1.00 47.57  ? 345 PRO A HB3  1 
ATOM   5195 H HG2  . PRO A 1 381 ? 6.278   -43.607 18.770  1.00 42.60  ? 345 PRO A HG2  1 
ATOM   5196 H HG3  . PRO A 1 381 ? 5.711   -42.236 18.201  1.00 42.60  ? 345 PRO A HG3  1 
ATOM   5197 H HD2  . PRO A 1 381 ? 6.467   -44.520 16.658  1.00 52.30  ? 345 PRO A HD2  1 
ATOM   5198 H HD3  . PRO A 1 381 ? 5.123   -43.687 16.501  1.00 52.30  ? 345 PRO A HD3  1 
ATOM   5199 N N    . ASP A 1 382 ? 9.527   -43.035 15.306  1.00 42.67  ? 346 ASP A N    1 
ATOM   5200 C CA   . ASP A 1 382 ? 10.848  -43.177 14.714  1.00 45.05  ? 346 ASP A CA   1 
ATOM   5201 C C    . ASP A 1 382 ? 10.779  -43.426 13.216  1.00 42.01  ? 346 ASP A C    1 
ATOM   5202 O O    . ASP A 1 382 ? 11.803  -43.749 12.604  1.00 44.44  ? 346 ASP A O    1 
ATOM   5203 C CB   . ASP A 1 382 ? 11.615  -44.319 15.387  1.00 44.53  ? 346 ASP A CB   1 
ATOM   5204 C CG   . ASP A 1 382 ? 10.833  -45.626 15.398  1.00 46.67  ? 346 ASP A CG   1 
ATOM   5205 O OD1  . ASP A 1 382 ? 9.644   -45.633 15.028  1.00 40.85  ? 346 ASP A OD1  1 
ATOM   5206 O OD2  . ASP A 1 382 ? 11.428  -46.662 15.752  1.00 50.20  ? 346 ASP A OD2  1 
ATOM   5207 H H    . ASP A 1 382 ? 9.044   -43.744 15.242  1.00 51.19  ? 346 ASP A H    1 
ATOM   5208 H HA   . ASP A 1 382 ? 11.342  -42.356 14.863  1.00 54.05  ? 346 ASP A HA   1 
ATOM   5209 H HB2  . ASP A 1 382 ? 12.444  -44.469 14.906  1.00 53.42  ? 346 ASP A HB2  1 
ATOM   5210 H HB3  . ASP A 1 382 ? 11.804  -44.074 16.306  1.00 53.42  ? 346 ASP A HB3  1 
ATOM   5211 N N    . GLY A 1 383 ? 9.598   -43.310 12.612  1.00 35.29  ? 347 GLY A N    1 
ATOM   5212 C CA   . GLY A 1 383 ? 9.454   -43.495 11.185  1.00 37.23  ? 347 GLY A CA   1 
ATOM   5213 C C    . GLY A 1 383 ? 9.679   -42.189 10.454  1.00 28.25  ? 347 GLY A C    1 
ATOM   5214 O O    . GLY A 1 383 ? 9.902   -41.144 11.057  1.00 36.83  ? 347 GLY A O    1 
ATOM   5215 H H    . GLY A 1 383 ? 8.863   -43.124 13.017  1.00 42.34  ? 347 GLY A H    1 
ATOM   5216 H HA2  . GLY A 1 383 ? 10.102  -44.146 10.871  1.00 44.67  ? 347 GLY A HA2  1 
ATOM   5217 H HA3  . GLY A 1 383 ? 8.561   -43.817 10.985  1.00 44.67  ? 347 GLY A HA3  1 
ATOM   5218 N N    . TRP A 1 384 ? 9.603   -42.254 9.127   1.00 26.29  ? 348 TRP A N    1 
ATOM   5219 C CA   . TRP A 1 384 ? 9.904   -41.093 8.291   1.00 29.93  ? 348 TRP A CA   1 
ATOM   5220 C C    . TRP A 1 384 ? 8.723   -40.739 7.407   1.00 29.33  ? 348 TRP A C    1 
ATOM   5221 O O    . TRP A 1 384 ? 8.876   -40.156 6.332   1.00 24.02  ? 348 TRP A O    1 
ATOM   5222 C CB   . TRP A 1 384 ? 11.177  -41.338 7.477   1.00 30.29  ? 348 TRP A CB   1 
ATOM   5223 C CG   . TRP A 1 384 ? 12.308  -41.538 8.411   1.00 26.32  ? 348 TRP A CG   1 
ATOM   5224 C CD1  . TRP A 1 384 ? 12.848  -42.734 8.811   1.00 34.89  ? 348 TRP A CD1  1 
ATOM   5225 C CD2  . TRP A 1 384 ? 13.031  -40.521 9.118   1.00 29.14  ? 348 TRP A CD2  1 
ATOM   5226 N NE1  . TRP A 1 384 ? 13.863  -42.517 9.722   1.00 32.12  ? 348 TRP A NE1  1 
ATOM   5227 C CE2  . TRP A 1 384 ? 13.998  -41.168 9.918   1.00 29.58  ? 348 TRP A CE2  1 
ATOM   5228 C CE3  . TRP A 1 384 ? 12.964  -39.122 9.145   1.00 27.41  ? 348 TRP A CE3  1 
ATOM   5229 C CZ2  . TRP A 1 384 ? 14.875  -40.475 10.729  1.00 32.61  ? 348 TRP A CZ2  1 
ATOM   5230 C CZ3  . TRP A 1 384 ? 13.839  -38.443 9.952   1.00 27.98  ? 348 TRP A CZ3  1 
ATOM   5231 C CH2  . TRP A 1 384 ? 14.789  -39.110 10.726  1.00 34.70  ? 348 TRP A CH2  1 
ATOM   5232 H H    . TRP A 1 384 ? 9.380   -42.960 8.688   1.00 31.54  ? 348 TRP A H    1 
ATOM   5233 H HA   . TRP A 1 384 ? 10.072  -40.321 8.854   1.00 35.91  ? 348 TRP A HA   1 
ATOM   5234 H HB2  . TRP A 1 384 ? 11.073  -42.132 6.931   1.00 36.33  ? 348 TRP A HB2  1 
ATOM   5235 H HB3  . TRP A 1 384 ? 11.364  -40.570 6.915   1.00 36.33  ? 348 TRP A HB3  1 
ATOM   5236 H HD1  . TRP A 1 384 ? 12.571  -43.570 8.512   1.00 41.86  ? 348 TRP A HD1  1 
ATOM   5237 H HE1  . TRP A 1 384 ? 14.334  -43.128 10.102  1.00 38.54  ? 348 TRP A HE1  1 
ATOM   5238 H HE3  . TRP A 1 384 ? 12.341  -38.666 8.628   1.00 32.88  ? 348 TRP A HE3  1 
ATOM   5239 H HZ2  . TRP A 1 384 ? 15.499  -40.919 11.257  1.00 39.12  ? 348 TRP A HZ2  1 
ATOM   5240 H HZ3  . TRP A 1 384 ? 13.799  -37.514 9.984   1.00 33.56  ? 348 TRP A HZ3  1 
ATOM   5241 H HH2  . TRP A 1 384 ? 15.376  -38.616 11.252  1.00 41.63  ? 348 TRP A HH2  1 
ATOM   5242 N N    . GLU A 1 385 ? 7.527   -41.079 7.870   1.00 24.32  ? 349 GLU A N    1 
ATOM   5243 C CA   . GLU A 1 385 ? 6.305   -40.640 7.232   1.00 21.91  ? 349 GLU A CA   1 
ATOM   5244 C C    . GLU A 1 385 ? 5.771   -39.466 8.029   1.00 22.88  ? 349 GLU A C    1 
ATOM   5245 O O    . GLU A 1 385 ? 5.766   -39.490 9.265   1.00 28.31  ? 349 GLU A O    1 
ATOM   5246 C CB   . GLU A 1 385 ? 5.275   -41.759 7.174   1.00 26.82  ? 349 GLU A CB   1 
ATOM   5247 C CG   . GLU A 1 385 ? 5.385   -42.576 5.920   1.00 30.26  ? 349 GLU A CG   1 
ATOM   5248 C CD   . GLU A 1 385 ? 4.401   -43.715 5.913   1.00 30.68  ? 349 GLU A CD   1 
ATOM   5249 O OE1  . GLU A 1 385 ? 3.189   -43.437 5.979   1.00 31.17  ? 349 GLU A OE1  1 
ATOM   5250 O OE2  . GLU A 1 385 ? 4.846   -44.870 5.825   1.00 36.00  ? 349 GLU A OE2  1 
ATOM   5251 H H    . GLU A 1 385 ? 7.402   -41.572 8.564   1.00 29.18  ? 349 GLU A H    1 
ATOM   5252 H HA   . GLU A 1 385 ? 6.478   -40.365 6.318   1.00 26.28  ? 349 GLU A HA   1 
ATOM   5253 H HB2  . GLU A 1 385 ? 5.407   -42.350 7.931   1.00 32.17  ? 349 GLU A HB2  1 
ATOM   5254 H HB3  . GLU A 1 385 ? 4.386   -41.372 7.205   1.00 32.17  ? 349 GLU A HB3  1 
ATOM   5255 H HG2  . GLU A 1 385 ? 5.203   -42.012 5.152   1.00 36.30  ? 349 GLU A HG2  1 
ATOM   5256 H HG3  . GLU A 1 385 ? 6.279   -42.946 5.856   1.00 36.30  ? 349 GLU A HG3  1 
ATOM   5257 N N    . PHE A 1 386 ? 5.383   -38.429 7.317   1.00 23.30  ? 350 PHE A N    1 
ATOM   5258 C CA   . PHE A 1 386 ? 4.858   -37.224 7.918   1.00 24.47  ? 350 PHE A CA   1 
ATOM   5259 C C    . PHE A 1 386 ? 3.626   -36.793 7.142   1.00 21.73  ? 350 PHE A C    1 
ATOM   5260 O O    . PHE A 1 386 ? 3.585   -36.880 5.909   1.00 21.80  ? 350 PHE A O    1 
ATOM   5261 C CB   . PHE A 1 386 ? 5.917   -36.130 7.911   1.00 22.58  ? 350 PHE A CB   1 
ATOM   5262 C CG   . PHE A 1 386 ? 7.175   -36.515 8.585   1.00 21.55  ? 350 PHE A CG   1 
ATOM   5263 C CD1  . PHE A 1 386 ? 8.149   -37.192 7.899   1.00 22.48  ? 350 PHE A CD1  1 
ATOM   5264 C CD2  . PHE A 1 386 ? 7.378   -36.244 9.938   1.00 21.20  ? 350 PHE A CD2  1 
ATOM   5265 C CE1  . PHE A 1 386 ? 9.312   -37.560 8.525   1.00 18.43  ? 350 PHE A CE1  1 
ATOM   5266 C CE2  . PHE A 1 386 ? 8.574   -36.612 10.564  1.00 21.64  ? 350 PHE A CE2  1 
ATOM   5267 C CZ   . PHE A 1 386 ? 9.515   -37.282 9.861   1.00 19.16  ? 350 PHE A CZ   1 
ATOM   5268 H H    . PHE A 1 386 ? 5.415   -38.398 6.458   1.00 27.95  ? 350 PHE A H    1 
ATOM   5269 H HA   . PHE A 1 386 ? 4.588   -37.380 8.837   1.00 29.35  ? 350 PHE A HA   1 
ATOM   5270 H HB2  . PHE A 1 386 ? 6.130   -35.907 6.991   1.00 27.09  ? 350 PHE A HB2  1 
ATOM   5271 H HB3  . PHE A 1 386 ? 5.563   -35.350 8.367   1.00 27.09  ? 350 PHE A HB3  1 
ATOM   5272 H HD1  . PHE A 1 386 ? 8.020   -37.404 7.002   1.00 26.96  ? 350 PHE A HD1  1 
ATOM   5273 H HD2  . PHE A 1 386 ? 6.714   -35.816 10.427  1.00 25.43  ? 350 PHE A HD2  1 
ATOM   5274 H HE1  . PHE A 1 386 ? 9.973   -38.002 8.043   1.00 22.11  ? 350 PHE A HE1  1 
ATOM   5275 H HE2  . PHE A 1 386 ? 8.721   -36.397 11.456  1.00 25.96  ? 350 PHE A HE2  1 
ATOM   5276 H HZ   . PHE A 1 386 ? 10.300  -37.556 10.278  1.00 22.98  ? 350 PHE A HZ   1 
ATOM   5277 N N    . THR A 1 387 ? 2.637   -36.309 7.863   1.00 21.59  ? 351 THR A N    1 
ATOM   5278 C CA   . THR A 1 387 ? 1.428   -35.793 7.252   1.00 18.34  ? 351 THR A CA   1 
ATOM   5279 C C    . THR A 1 387 ? 1.114   -34.430 7.830   1.00 21.67  ? 351 THR A C    1 
ATOM   5280 O O    . THR A 1 387 ? 1.504   -34.102 8.956   1.00 20.82  ? 351 THR A O    1 
ATOM   5281 C CB   . THR A 1 387 ? 0.212   -36.715 7.475   1.00 23.16  ? 351 THR A CB   1 
ATOM   5282 O OG1  . THR A 1 387 ? -0.058  -36.839 8.878   1.00 24.48  ? 351 THR A OG1  1 
ATOM   5283 C CG2  . THR A 1 387 ? 0.492   -38.053 6.894   1.00 23.60  ? 351 THR A CG2  1 
ATOM   5284 H H    . THR A 1 387 ? 2.641   -36.267 8.722   1.00 25.90  ? 351 THR A H    1 
ATOM   5285 H HA   . THR A 1 387 ? 1.577   -35.714 6.297   1.00 22.00  ? 351 THR A HA   1 
ATOM   5286 H HB   . THR A 1 387 ? -0.572  -36.344 7.043   1.00 27.78  ? 351 THR A HB   1 
ATOM   5287 H HG1  . THR A 1 387 ? -0.252  -36.087 9.200   1.00 29.37  ? 351 THR A HG1  1 
ATOM   5288 H HG21 . THR A 1 387 ? -0.243  -38.657 7.083   1.00 28.31  ? 351 THR A HG21 1 
ATOM   5289 H HG22 . THR A 1 387 ? 0.601   -37.980 5.933   1.00 28.31  ? 351 THR A HG22 1 
ATOM   5290 H HG23 . THR A 1 387 ? 1.305   -38.417 7.277   1.00 28.31  ? 351 THR A HG23 1 
ATOM   5291 N N    . ARG A 1 388 ? 0.400   -33.636 7.038   1.00 20.54  ? 352 ARG A N    1 
ATOM   5292 C CA   . ARG A 1 388 ? -0.113  -32.375 7.548   1.00 18.52  ? 352 ARG A CA   1 
ATOM   5293 C C    . ARG A 1 388 ? -1.352  -31.960 6.770   1.00 16.39  ? 352 ARG A C    1 
ATOM   5294 O O    . ARG A 1 388 ? -1.467  -32.196 5.562   1.00 19.63  ? 352 ARG A O    1 
ATOM   5295 C CB   . ARG A 1 388 ? 0.968   -31.311 7.483   1.00 16.00  ? 352 ARG A CB   1 
ATOM   5296 C CG   . ARG A 1 388 ? 0.581   -30.055 8.201   1.00 18.07  ? 352 ARG A CG   1 
ATOM   5297 C CD   . ARG A 1 388 ? 1.717   -29.034 8.135   1.00 16.37  ? 352 ARG A CD   1 
ATOM   5298 N NE   . ARG A 1 388 ? 1.444   -27.908 9.000   1.00 16.83  ? 352 ARG A NE   1 
ATOM   5299 C CZ   . ARG A 1 388 ? 2.173   -26.805 9.029   1.00 17.62  ? 352 ARG A CZ   1 
ATOM   5300 N NH1  . ARG A 1 388 ? 3.205   -26.647 8.215   1.00 17.74  ? 352 ARG A NH1  1 
ATOM   5301 N NH2  . ARG A 1 388 ? 1.894   -25.868 9.922   1.00 19.66  ? 352 ARG A NH2  1 
ATOM   5302 H H    . ARG A 1 388 ? 0.205   -33.804 6.217   1.00 24.64  ? 352 ARG A H    1 
ATOM   5303 H HA   . ARG A 1 388 ? -0.398  -32.476 8.469   1.00 22.21  ? 352 ARG A HA   1 
ATOM   5304 H HB2  . ARG A 1 388 ? 1.776   -31.656 7.893   1.00 19.19  ? 352 ARG A HB2  1 
ATOM   5305 H HB3  . ARG A 1 388 ? 1.136   -31.088 6.554   1.00 19.19  ? 352 ARG A HB3  1 
ATOM   5306 H HG2  . ARG A 1 388 ? -0.205  -29.670 7.783   1.00 21.67  ? 352 ARG A HG2  1 
ATOM   5307 H HG3  . ARG A 1 388 ? 0.398   -30.255 9.132   1.00 21.67  ? 352 ARG A HG3  1 
ATOM   5308 H HD2  . ARG A 1 388 ? 2.545   -29.451 8.423   1.00 19.63  ? 352 ARG A HD2  1 
ATOM   5309 H HD3  . ARG A 1 388 ? 1.809   -28.710 7.225   1.00 19.63  ? 352 ARG A HD3  1 
ATOM   5310 H HE   . ARG A 1 388 ? 0.766   -27.958 9.527   1.00 20.19  ? 352 ARG A HE   1 
ATOM   5311 H HH11 . ARG A 1 388 ? 3.410   -27.268 7.656   1.00 21.28  ? 352 ARG A HH11 1 
ATOM   5312 H HH12 . ARG A 1 388 ? 3.670   -25.925 8.246   1.00 21.28  ? 352 ARG A HH12 1 
ATOM   5313 H HH21 . ARG A 1 388 ? 1.244   -25.980 10.474  1.00 23.58  ? 352 ARG A HH21 1 
ATOM   5314 H HH22 . ARG A 1 388 ? 2.361   -25.147 9.949   1.00 23.58  ? 352 ARG A HH22 1 
ATOM   5315 N N    . GLU A 1 389 ? -2.275  -31.336 7.479   1.00 20.76  ? 353 GLU A N    1 
ATOM   5316 C CA   . GLU A 1 389 ? -3.535  -30.901 6.903   1.00 19.75  ? 353 GLU A CA   1 
ATOM   5317 C C    . GLU A 1 389 ? -3.583  -29.385 6.774   1.00 16.92  ? 353 GLU A C    1 
ATOM   5318 O O    . GLU A 1 389 ? -3.357  -28.674 7.751   1.00 17.97  ? 353 GLU A O    1 
ATOM   5319 C CB   . GLU A 1 389 ? -4.702  -31.388 7.755   1.00 21.01  ? 353 GLU A CB   1 
ATOM   5320 C CG   . GLU A 1 389 ? -4.635  -32.898 7.978   1.00 19.79  ? 353 GLU A CG   1 
ATOM   5321 C CD   . GLU A 1 389 ? -4.931  -33.705 6.726   1.00 30.84  ? 353 GLU A CD   1 
ATOM   5322 O OE1  . GLU A 1 389 ? -5.596  -33.175 5.818   1.00 26.98  ? 353 GLU A OE1  1 
ATOM   5323 O OE2  . GLU A 1 389 ? -4.495  -34.879 6.658   1.00 33.18  ? 353 GLU A OE2  1 
ATOM   5324 H H    . GLU A 1 389 ? -2.193  -31.148 8.315   1.00 24.90  ? 353 GLU A H    1 
ATOM   5325 H HA   . GLU A 1 389 ? -3.611  -31.266 6.007   1.00 23.69  ? 353 GLU A HA   1 
ATOM   5326 H HB2  . GLU A 1 389 ? -4.673  -30.949 8.619   1.00 25.20  ? 353 GLU A HB2  1 
ATOM   5327 H HB3  . GLU A 1 389 ? -5.536  -31.182 7.305   1.00 25.20  ? 353 GLU A HB3  1 
ATOM   5328 H HG2  . GLU A 1 389 ? -3.742  -33.132 8.278   1.00 23.74  ? 353 GLU A HG2  1 
ATOM   5329 H HG3  . GLU A 1 389 ? -5.287  -33.145 8.652   1.00 23.74  ? 353 GLU A HG3  1 
ATOM   5330 N N    . PHE A 1 390 ? -3.947  -28.926 5.586   1.00 15.50  ? 354 PHE A N    1 
ATOM   5331 C CA   . PHE A 1 390 ? -4.296  -27.544 5.292   1.00 17.93  ? 354 PHE A CA   1 
ATOM   5332 C C    . PHE A 1 390 ? -5.766  -27.463 4.920   1.00 19.80  ? 354 PHE A C    1 
ATOM   5333 O O    . PHE A 1 390 ? -6.431  -28.470 4.656   1.00 19.17  ? 354 PHE A O    1 
ATOM   5334 C CB   . PHE A 1 390 ? -3.436  -27.038 4.155   1.00 20.15  ? 354 PHE A CB   1 
ATOM   5335 C CG   . PHE A 1 390 ? -1.983  -26.988 4.493   1.00 19.43  ? 354 PHE A CG   1 
ATOM   5336 C CD1  . PHE A 1 390 ? -1.228  -28.124 4.575   1.00 17.73  ? 354 PHE A CD1  1 
ATOM   5337 C CD2  . PHE A 1 390 ? -1.391  -25.776 4.766   1.00 18.82  ? 354 PHE A CD2  1 
ATOM   5338 C CE1  . PHE A 1 390 ? 0.098   -28.061 4.887   1.00 18.87  ? 354 PHE A CE1  1 
ATOM   5339 C CE2  . PHE A 1 390 ? -0.072  -25.707 5.068   1.00 16.86  ? 354 PHE A CE2  1 
ATOM   5340 C CZ   . PHE A 1 390 ? 0.686   -26.876 5.120   1.00 16.28  ? 354 PHE A CZ   1 
ATOM   5341 H H    . PHE A 1 390 ? -4.003  -29.428 4.890   1.00 18.59  ? 354 PHE A H    1 
ATOM   5342 H HA   . PHE A 1 390 ? -4.147  -26.983 6.069   1.00 21.51  ? 354 PHE A HA   1 
ATOM   5343 H HB2  . PHE A 1 390 ? -3.544  -27.629 3.393   1.00 24.17  ? 354 PHE A HB2  1 
ATOM   5344 H HB3  . PHE A 1 390 ? -3.719  -26.141 3.921   1.00 24.17  ? 354 PHE A HB3  1 
ATOM   5345 H HD1  . PHE A 1 390 ? -1.623  -28.951 4.415   1.00 21.27  ? 354 PHE A HD1  1 
ATOM   5346 H HD2  . PHE A 1 390 ? -1.901  -24.998 4.744   1.00 22.58  ? 354 PHE A HD2  1 
ATOM   5347 H HE1  . PHE A 1 390 ? 0.598   -28.844 4.939   1.00 22.63  ? 354 PHE A HE1  1 
ATOM   5348 H HE2  . PHE A 1 390 ? 0.326   -24.884 5.239   1.00 20.22  ? 354 PHE A HE2  1 
ATOM   5349 H HZ   . PHE A 1 390 ? 1.595   -26.835 5.314   1.00 19.52  ? 354 PHE A HZ   1 
ATOM   5350 N N    . GLU A 1 391 ? -6.287  -26.251 4.874   1.00 19.37  ? 355 GLU A N    1 
ATOM   5351 C CA   . GLU A 1 391 ? -7.721  -26.145 4.653   1.00 21.36  ? 355 GLU A CA   1 
ATOM   5352 C C    . GLU A 1 391 ? -8.137  -26.797 3.340   1.00 25.90  ? 355 GLU A C    1 
ATOM   5353 O O    . GLU A 1 391 ? -9.229  -27.388 3.255   1.00 22.77  ? 355 GLU A O    1 
ATOM   5354 C CB   . GLU A 1 391 ? -8.148  -24.684 4.686   1.00 24.96  ? 355 GLU A CB   1 
ATOM   5355 C CG   . GLU A 1 391 ? -9.641  -24.539 4.777   1.00 32.32  ? 355 GLU A CG   1 
ATOM   5356 C CD   . GLU A 1 391 ? -10.257 -25.359 5.898   1.00 29.44  ? 355 GLU A CD   1 
ATOM   5357 O OE1  . GLU A 1 391 ? -9.742  -25.276 7.045   1.00 23.12  ? 355 GLU A OE1  1 
ATOM   5358 O OE2  . GLU A 1 391 ? -11.275 -26.051 5.612   1.00 35.92  ? 355 GLU A OE2  1 
ATOM   5359 H H    . GLU A 1 391 ? -5.858  -25.510 4.962   1.00 23.24  ? 355 GLU A H    1 
ATOM   5360 H HA   . GLU A 1 391 ? -8.183  -26.606 5.371   1.00 25.62  ? 355 GLU A HA   1 
ATOM   5361 H HB2  . GLU A 1 391 ? -7.753  -24.254 5.461   1.00 29.94  ? 355 GLU A HB2  1 
ATOM   5362 H HB3  . GLU A 1 391 ? -7.849  -24.246 3.875   1.00 29.94  ? 355 GLU A HB3  1 
ATOM   5363 H HG2  . GLU A 1 391 ? -9.857  -23.607 4.937   1.00 38.77  ? 355 GLU A HG2  1 
ATOM   5364 H HG3  . GLU A 1 391 ? -10.036 -24.833 3.942   1.00 38.77  ? 355 GLU A HG3  1 
ATOM   5365 N N    . HIS A 1 392 ? -7.291  -26.736 2.315   1.00 18.94  ? 356 HIS A N    1 
ATOM   5366 C CA   . HIS A 1 392 ? -7.653  -27.229 0.991   1.00 24.54  ? 356 HIS A CA   1 
ATOM   5367 C C    . HIS A 1 392 ? -6.745  -28.338 0.499   1.00 20.69  ? 356 HIS A C    1 
ATOM   5368 O O    . HIS A 1 392 ? -6.761  -28.646 -0.694  1.00 23.57  ? 356 HIS A O    1 
ATOM   5369 C CB   . HIS A 1 392 ? -7.669  -26.067 0.002   1.00 20.32  ? 356 HIS A CB   1 
ATOM   5370 C CG   . HIS A 1 392 ? -8.446  -24.919 0.519   1.00 20.97  ? 356 HIS A CG   1 
ATOM   5371 N ND1  . HIS A 1 392 ? -9.764  -25.055 0.900   1.00 17.99  ? 356 HIS A ND1  1 
ATOM   5372 C CD2  . HIS A 1 392 ? -8.100  -23.636 0.780   1.00 19.16  ? 356 HIS A CD2  1 
ATOM   5373 C CE1  . HIS A 1 392 ? -10.194 -23.899 1.374   1.00 21.54  ? 356 HIS A CE1  1 
ATOM   5374 N NE2  . HIS A 1 392 ? -9.209  -23.025 1.304   1.00 21.50  ? 356 HIS A NE2  1 
ATOM   5375 H H    . HIS A 1 392 ? -6.496  -26.412 2.363   1.00 22.72  ? 356 HIS A H    1 
ATOM   5376 H HA   . HIS A 1 392 ? -8.543  -27.610 1.040   1.00 29.43  ? 356 HIS A HA   1 
ATOM   5377 H HB2  . HIS A 1 392 ? -6.760  -25.772 -0.160  1.00 24.37  ? 356 HIS A HB2  1 
ATOM   5378 H HB3  . HIS A 1 392 ? -8.076  -26.360 -0.829  1.00 24.37  ? 356 HIS A HB3  1 
ATOM   5379 H HD2  . HIS A 1 392 ? -7.269  -23.244 0.632   1.00 22.98  ? 356 HIS A HD2  1 
ATOM   5380 H HE1  . HIS A 1 392 ? -11.048 -23.731 1.702   1.00 25.83  ? 356 HIS A HE1  1 
ATOM   5381 H HE2  . HIS A 1 392 ? -9.256  -22.201 1.549   1.00 25.78  ? 356 HIS A HE2  1 
ATOM   5382 N N    . ALA A 1 393 ? -5.964  -28.955 1.387   1.00 19.46  ? 357 ALA A N    1 
ATOM   5383 C CA   . ALA A 1 393 ? -5.030  -29.984 0.935   1.00 21.41  ? 357 ALA A CA   1 
ATOM   5384 C C    . ALA A 1 393 ? -4.581  -30.848 2.100   1.00 24.60  ? 357 ALA A C    1 
ATOM   5385 O O    . ALA A 1 393 ? -4.484  -30.396 3.237   1.00 22.11  ? 357 ALA A O    1 
ATOM   5386 C CB   . ALA A 1 393 ? -3.783  -29.391 0.268   1.00 21.50  ? 357 ALA A CB   1 
ATOM   5387 H H    . ALA A 1 393 ? -5.957  -28.799 2.232   1.00 23.34  ? 357 ALA A H    1 
ATOM   5388 H HA   . ALA A 1 393 ? -5.509  -30.539 0.300   1.00 25.68  ? 357 ALA A HA   1 
ATOM   5389 H HB1  . ALA A 1 393 ? -3.188  -30.113 0.012   1.00 25.79  ? 357 ALA A HB1  1 
ATOM   5390 H HB2  . ALA A 1 393 ? -4.053  -28.891 -0.517  1.00 25.79  ? 357 ALA A HB2  1 
ATOM   5391 H HB3  . ALA A 1 393 ? -3.338  -28.803 0.898   1.00 25.79  ? 357 ALA A HB3  1 
ATOM   5392 N N    . SER A 1 394 ? -4.286  -32.094 1.786   1.00 24.21  ? 358 SER A N    1 
ATOM   5393 C CA   . SER A 1 394 ? -3.778  -33.048 2.749   1.00 20.58  ? 358 SER A CA   1 
ATOM   5394 C C    . SER A 1 394 ? -2.434  -33.500 2.222   1.00 20.43  ? 358 SER A C    1 
ATOM   5395 O O    . SER A 1 394 ? -2.317  -33.856 1.044   1.00 26.27  ? 358 SER A O    1 
ATOM   5396 C CB   . SER A 1 394 ? -4.738  -34.232 2.931   1.00 26.32  ? 358 SER A CB   1 
ATOM   5397 O OG   . SER A 1 394 ? -4.186  -35.147 3.860   1.00 30.94  ? 358 SER A OG   1 
ATOM   5398 H H    . SER A 1 394 ? -4.374  -32.421 0.996   1.00 29.05  ? 358 SER A H    1 
ATOM   5399 H HA   . SER A 1 394 ? -3.672  -32.651 3.628   1.00 24.69  ? 358 SER A HA   1 
ATOM   5400 H HB2  . SER A 1 394 ? -5.589  -33.908 3.265   1.00 31.58  ? 358 SER A HB2  1 
ATOM   5401 H HB3  . SER A 1 394 ? -4.865  -34.677 2.078   1.00 31.58  ? 358 SER A HB3  1 
ATOM   5402 H HG   . SER A 1 394 ? -4.746  -35.747 4.040   1.00 37.12  ? 358 SER A HG   1 
ATOM   5403 N N    . VAL A 1 395 ? -1.415  -33.428 3.064   1.00 23.53  ? 359 VAL A N    1 
ATOM   5404 C CA   . VAL A 1 395 ? -0.046  -33.695 2.651   1.00 18.83  ? 359 VAL A CA   1 
ATOM   5405 C C    . VAL A 1 395 ? 0.427   -34.989 3.274   1.00 20.25  ? 359 VAL A C    1 
ATOM   5406 O O    . VAL A 1 395 ? 0.296   -35.184 4.481   1.00 21.01  ? 359 VAL A O    1 
ATOM   5407 C CB   . VAL A 1 395 ? 0.904   -32.564 3.076   1.00 20.14  ? 359 VAL A CB   1 
ATOM   5408 C CG1  . VAL A 1 395 ? 2.295   -32.852 2.600   1.00 23.09  ? 359 VAL A CG1  1 
ATOM   5409 C CG2  . VAL A 1 395 ? 0.387   -31.227 2.570   1.00 22.04  ? 359 VAL A CG2  1 
ATOM   5410 H H    . VAL A 1 395 ? -1.493  -33.221 3.895   1.00 28.22  ? 359 VAL A H    1 
ATOM   5411 H HA   . VAL A 1 395 ? -0.043  -33.788 1.685   1.00 22.58  ? 359 VAL A HA   1 
ATOM   5412 H HB   . VAL A 1 395 ? 0.939   -32.509 4.044   1.00 24.16  ? 359 VAL A HB   1 
ATOM   5413 H HG11 . VAL A 1 395 ? 2.827   -32.043 2.671   1.00 27.70  ? 359 VAL A HG11 1 
ATOM   5414 H HG12 . VAL A 1 395 ? 2.680   -33.550 3.152   1.00 27.70  ? 359 VAL A HG12 1 
ATOM   5415 H HG13 . VAL A 1 395 ? 2.259   -33.143 1.675   1.00 27.70  ? 359 VAL A HG13 1 
ATOM   5416 H HG21 . VAL A 1 395 ? 1.022   -30.533 2.807   1.00 26.44  ? 359 VAL A HG21 1 
ATOM   5417 H HG22 . VAL A 1 395 ? 0.288   -31.270 1.606   1.00 26.44  ? 359 VAL A HG22 1 
ATOM   5418 H HG23 . VAL A 1 395 ? -0.472  -31.043 2.983   1.00 26.44  ? 359 VAL A HG23 1 
ATOM   5419 N N    . TRP A 1 396 ? 1.050   -35.824 2.473   1.00 20.52  ? 360 TRP A N    1 
ATOM   5420 C CA   . TRP A 1 396 ? 1.705   -37.019 2.963   1.00 21.86  ? 360 TRP A CA   1 
ATOM   5421 C C    . TRP A 1 396 ? 3.064   -37.108 2.313   1.00 20.62  ? 360 TRP A C    1 
ATOM   5422 O O    . TRP A 1 396 ? 3.182   -36.958 1.097   1.00 23.09  ? 360 TRP A O    1 
ATOM   5423 C CB   . TRP A 1 396 ? 0.913   -38.302 2.643   1.00 23.50  ? 360 TRP A CB   1 
ATOM   5424 C CG   . TRP A 1 396 ? 1.688   -39.554 3.009   1.00 26.80  ? 360 TRP A CG   1 
ATOM   5425 C CD1  . TRP A 1 396 ? 1.731   -40.171 4.225   1.00 31.56  ? 360 TRP A CD1  1 
ATOM   5426 C CD2  . TRP A 1 396 ? 2.545   -40.315 2.148   1.00 28.55  ? 360 TRP A CD2  1 
ATOM   5427 N NE1  . TRP A 1 396 ? 2.560   -41.279 4.172   1.00 29.80  ? 360 TRP A NE1  1 
ATOM   5428 C CE2  . TRP A 1 396 ? 3.068   -41.382 2.906   1.00 30.75  ? 360 TRP A CE2  1 
ATOM   5429 C CE3  . TRP A 1 396 ? 2.911   -40.200 0.807   1.00 27.62  ? 360 TRP A CE3  1 
ATOM   5430 C CZ2  . TRP A 1 396 ? 3.947   -42.326 2.364   1.00 27.80  ? 360 TRP A CZ2  1 
ATOM   5431 C CZ3  . TRP A 1 396 ? 3.773   -41.140 0.267   1.00 26.48  ? 360 TRP A CZ3  1 
ATOM   5432 C CH2  . TRP A 1 396 ? 4.282   -42.187 1.043   1.00 31.98  ? 360 TRP A CH2  1 
ATOM   5433 H H    . TRP A 1 396 ? 1.110   -35.720 1.621   1.00 24.61  ? 360 TRP A H    1 
ATOM   5434 H HA   . TRP A 1 396 ? 1.793   -36.963 3.928   1.00 26.23  ? 360 TRP A HA   1 
ATOM   5435 H HB2  . TRP A 1 396 ? 0.085   -38.300 3.148   1.00 28.19  ? 360 TRP A HB2  1 
ATOM   5436 H HB3  . TRP A 1 396 ? 0.722   -38.330 1.693   1.00 28.19  ? 360 TRP A HB3  1 
ATOM   5437 H HD1  . TRP A 1 396 ? 1.269   -39.888 4.981   1.00 37.86  ? 360 TRP A HD1  1 
ATOM   5438 H HE1  . TRP A 1 396 ? 2.727   -41.812 4.825   1.00 35.75  ? 360 TRP A HE1  1 
ATOM   5439 H HE3  . TRP A 1 396 ? 2.583   -39.504 0.285   1.00 33.13  ? 360 TRP A HE3  1 
ATOM   5440 H HZ2  . TRP A 1 396 ? 4.290   -43.020 2.879   1.00 33.35  ? 360 TRP A HZ2  1 
ATOM   5441 H HZ3  . TRP A 1 396 ? 4.018   -41.074 -0.628  1.00 31.77  ? 360 TRP A HZ3  1 
ATOM   5442 H HH2  . TRP A 1 396 ? 4.860   -42.802 0.654   1.00 38.36  ? 360 TRP A HH2  1 
ATOM   5443 N N    . VAL A 1 397 ? 4.075   -37.422 3.101   1.00 22.04  ? 361 VAL A N    1 
ATOM   5444 C CA   . VAL A 1 397 ? 5.398   -37.607 2.529   1.00 26.47  ? 361 VAL A CA   1 
ATOM   5445 C C    . VAL A 1 397 ? 6.145   -38.630 3.353   1.00 23.06  ? 361 VAL A C    1 
ATOM   5446 O O    . VAL A 1 397 ? 6.035   -38.667 4.585   1.00 24.50  ? 361 VAL A O    1 
ATOM   5447 C CB   . VAL A 1 397 ? 6.180   -36.273 2.444   1.00 25.20  ? 361 VAL A CB   1 
ATOM   5448 C CG1  . VAL A 1 397 ? 6.445   -35.717 3.827   1.00 26.83  ? 361 VAL A CG1  1 
ATOM   5449 C CG2  . VAL A 1 397 ? 7.482   -36.476 1.717   1.00 26.01  ? 361 VAL A CG2  1 
ATOM   5450 H H    . VAL A 1 397 ? 4.023   -37.533 3.953   1.00 26.43  ? 361 VAL A H    1 
ATOM   5451 H HA   . VAL A 1 397 ? 5.301   -37.957 1.629   1.00 31.76  ? 361 VAL A HA   1 
ATOM   5452 H HB   . VAL A 1 397 ? 5.642   -35.632 1.954   1.00 30.23  ? 361 VAL A HB   1 
ATOM   5453 H HG11 . VAL A 1 397 ? 6.821   -34.827 3.742   1.00 32.19  ? 361 VAL A HG11 1 
ATOM   5454 H HG12 . VAL A 1 397 ? 5.608   -35.677 4.317   1.00 32.19  ? 361 VAL A HG12 1 
ATOM   5455 H HG13 . VAL A 1 397 ? 7.070   -36.298 4.287   1.00 32.19  ? 361 VAL A HG13 1 
ATOM   5456 H HG21 . VAL A 1 397 ? 7.845   -35.611 1.472   1.00 31.20  ? 361 VAL A HG21 1 
ATOM   5457 H HG22 . VAL A 1 397 ? 8.101   -36.941 2.302   1.00 31.20  ? 361 VAL A HG22 1 
ATOM   5458 H HG23 . VAL A 1 397 ? 7.320   -37.005 0.920   1.00 31.20  ? 361 VAL A HG23 1 
ATOM   5459 N N    . ASN A 1 398 ? 6.924   -39.451 2.653   1.00 23.13  ? 362 ASN A N    1 
ATOM   5460 C CA   . ASN A 1 398 ? 7.897   -40.337 3.272   1.00 24.66  ? 362 ASN A CA   1 
ATOM   5461 C C    . ASN A 1 398 ? 9.274   -39.895 2.808   1.00 21.77  ? 362 ASN A C    1 
ATOM   5462 O O    . ASN A 1 398 ? 9.612   -40.053 1.630   1.00 24.28  ? 362 ASN A O    1 
ATOM   5463 C CB   . ASN A 1 398 ? 7.672   -41.793 2.905   1.00 27.73  ? 362 ASN A CB   1 
ATOM   5464 C CG   . ASN A 1 398 ? 8.640   -42.715 3.621   1.00 29.16  ? 362 ASN A CG   1 
ATOM   5465 O OD1  . ASN A 1 398 ? 9.804   -42.374 3.845   1.00 26.76  ? 362 ASN A OD1  1 
ATOM   5466 N ND2  . ASN A 1 398 ? 8.154   -43.892 4.006   1.00 33.89  ? 362 ASN A ND2  1 
ATOM   5467 H H    . ASN A 1 398 ? 6.903   -39.512 1.795   1.00 27.74  ? 362 ASN A H    1 
ATOM   5468 H HA   . ASN A 1 398 ? 7.822   -40.255 4.236   1.00 29.58  ? 362 ASN A HA   1 
ATOM   5469 H HB2  . ASN A 1 398 ? 6.770   -42.049 3.154   1.00 33.27  ? 362 ASN A HB2  1 
ATOM   5470 H HB3  . ASN A 1 398 ? 7.797   -41.905 1.950   1.00 33.27  ? 362 ASN A HB3  1 
ATOM   5471 H HD21 . ASN A 1 398 ? 8.661   -44.453 4.416   1.00 40.66  ? 362 ASN A HD21 1 
ATOM   5472 H HD22 . ASN A 1 398 ? 7.333   -44.092 3.845   1.00 40.66  ? 362 ASN A HD22 1 
ATOM   5473 N N    . THR A 1 399 ? 10.026  -39.292 3.713   1.00 25.37  ? 363 THR A N    1 
ATOM   5474 C CA   . THR A 1 399 ? 11.302  -38.703 3.356   1.00 24.87  ? 363 THR A CA   1 
ATOM   5475 C C    . THR A 1 399 ? 12.419  -39.728 3.374   1.00 30.87  ? 363 THR A C    1 
ATOM   5476 O O    . THR A 1 399 ? 13.540  -39.402 2.981   1.00 28.54  ? 363 THR A O    1 
ATOM   5477 C CB   . THR A 1 399 ? 11.655  -37.570 4.307   1.00 21.75  ? 363 THR A CB   1 
ATOM   5478 O OG1  . THR A 1 399 ? 11.619  -38.035 5.660   1.00 24.53  ? 363 THR A OG1  1 
ATOM   5479 C CG2  . THR A 1 399 ? 10.685  -36.412 4.126   1.00 23.78  ? 363 THR A CG2  1 
ATOM   5480 H H    . THR A 1 399 ? 9.818   -39.211 4.544   1.00 30.43  ? 363 THR A H    1 
ATOM   5481 H HA   . THR A 1 399 ? 11.232  -38.324 2.465   1.00 29.83  ? 363 THR A HA   1 
ATOM   5482 H HB   . THR A 1 399 ? 12.550  -37.250 4.115   1.00 26.09  ? 363 THR A HB   1 
ATOM   5483 H HG1  . THR A 1 399 ? 11.856  -37.421 6.181   1.00 29.42  ? 363 THR A HG1  1 
ATOM   5484 H HG21 . THR A 1 399 ? 10.904  -35.697 4.744   1.00 28.52  ? 363 THR A HG21 1 
ATOM   5485 H HG22 . THR A 1 399 ? 10.739  -36.072 3.219   1.00 28.52  ? 363 THR A HG22 1 
ATOM   5486 H HG23 . THR A 1 399 ? 9.778   -36.709 4.297   1.00 28.52  ? 363 THR A HG23 1 
ATOM   5487 N N    . GLU A 1 400 ? 12.139  -40.930 3.878   1.00 29.07  ? 364 GLU A N    1 
ATOM   5488 C CA   . GLU A 1 400 ? 13.078  -42.033 3.723   1.00 33.93  ? 364 GLU A CA   1 
ATOM   5489 C C    . GLU A 1 400 ? 13.059  -42.557 2.295   1.00 31.73  ? 364 GLU A C    1 
ATOM   5490 O O    . GLU A 1 400 ? 14.113  -42.747 1.680   1.00 35.48  ? 364 GLU A O    1 
ATOM   5491 C CB   . GLU A 1 400 ? 12.736  -43.147 4.701   1.00 37.07  ? 364 GLU A CB   1 
ATOM   5492 C CG   . GLU A 1 400 ? 13.793  -44.223 4.806   1.00 39.68  ? 364 GLU A CG   1 
ATOM   5493 C CD   . GLU A 1 400 ? 13.501  -45.151 5.961   1.00 42.87  ? 364 GLU A CD   1 
ATOM   5494 O OE1  . GLU A 1 400 ? 12.319  -45.526 6.122   1.00 45.66  ? 364 GLU A OE1  1 
ATOM   5495 O OE2  . GLU A 1 400 ? 14.433  -45.447 6.732   1.00 43.42  ? 364 GLU A OE2  1 
ATOM   5496 H H    . GLU A 1 400 ? 11.421  -41.128 4.308   1.00 34.88  ? 364 GLU A H    1 
ATOM   5497 H HA   . GLU A 1 400 ? 13.973  -41.719 3.925   1.00 40.71  ? 364 GLU A HA   1 
ATOM   5498 H HB2  . GLU A 1 400 ? 12.620  -42.761 5.583   1.00 44.47  ? 364 GLU A HB2  1 
ATOM   5499 H HB3  . GLU A 1 400 ? 11.912  -43.570 4.413   1.00 44.47  ? 364 GLU A HB3  1 
ATOM   5500 H HG2  . GLU A 1 400 ? 13.807  -44.745 3.988   1.00 47.61  ? 364 GLU A HG2  1 
ATOM   5501 H HG3  . GLU A 1 400 ? 14.659  -43.812 4.953   1.00 47.61  ? 364 GLU A HG3  1 
ATOM   5502 N N    . THR A 1 401 ? 11.868  -42.777 1.744   1.00 31.49  ? 365 THR A N    1 
ATOM   5503 C CA   . THR A 1 401 ? 11.724  -43.328 0.403   1.00 29.20  ? 365 THR A CA   1 
ATOM   5504 C C    . THR A 1 401 ? 11.637  -42.277 -0.698  1.00 33.92  ? 365 THR A C    1 
ATOM   5505 O O    . THR A 1 401 ? 11.813  -42.621 -1.872  1.00 34.83  ? 365 THR A O    1 
ATOM   5506 C CB   . THR A 1 401 ? 10.482  -44.234 0.331   1.00 34.66  ? 365 THR A CB   1 
ATOM   5507 O OG1  . THR A 1 401 ? 9.281   -43.455 0.439   1.00 34.88  ? 365 THR A OG1  1 
ATOM   5508 C CG2  . THR A 1 401 ? 10.504  -45.287 1.459   1.00 35.17  ? 365 THR A CG2  1 
ATOM   5509 H H    . THR A 1 401 ? 11.119  -42.612 2.133   1.00 37.77  ? 365 THR A H    1 
ATOM   5510 H HA   . THR A 1 401 ? 12.508  -43.869 0.220   1.00 35.03  ? 365 THR A HA   1 
ATOM   5511 H HB   . THR A 1 401 ? 10.485  -44.693 -0.524  1.00 41.58  ? 365 THR A HB   1 
ATOM   5512 H HG1  . THR A 1 401 ? 9.131   -43.056 -0.284  1.00 41.85  ? 365 THR A HG1  1 
ATOM   5513 H HG21 . THR A 1 401 ? 9.765   -45.906 1.349   1.00 42.19  ? 365 THR A HG21 1 
ATOM   5514 H HG22 . THR A 1 401 ? 11.337  -45.784 1.433   1.00 42.19  ? 365 THR A HG22 1 
ATOM   5515 H HG23 . THR A 1 401 ? 10.423  -44.851 2.322   1.00 42.19  ? 365 THR A HG23 1 
ATOM   5516 N N    . GLY A 1 402 ? 11.374  -41.012 -0.370  1.00 34.19  ? 366 GLY A N    1 
ATOM   5517 C CA   . GLY A 1 402 ? 11.266  -40.001 -1.404  1.00 29.41  ? 366 GLY A CA   1 
ATOM   5518 C C    . GLY A 1 402 ? 9.964   -39.985 -2.164  1.00 32.93  ? 366 GLY A C    1 
ATOM   5519 O O    . GLY A 1 402 ? 9.939   -39.614 -3.345  1.00 34.97  ? 366 GLY A O    1 
ATOM   5520 H H    . GLY A 1 402 ? 11.256  -40.724 0.432   1.00 41.01  ? 366 GLY A H    1 
ATOM   5521 H HA2  . GLY A 1 402 ? 11.377  -39.128 -0.994  1.00 35.29  ? 366 GLY A HA2  1 
ATOM   5522 H HA3  . GLY A 1 402 ? 11.978  -40.141 -2.047  1.00 35.29  ? 366 GLY A HA3  1 
ATOM   5523 N N    . ASN A 1 403 ? 8.876   -40.392 -1.531  1.00 32.42  ? 367 ASN A N    1 
ATOM   5524 C CA   . ASN A 1 403 ? 7.568   -40.394 -2.157  1.00 28.97  ? 367 ASN A CA   1 
ATOM   5525 C C    . ASN A 1 403 ? 6.669   -39.435 -1.399  1.00 21.41  ? 367 ASN A C    1 
ATOM   5526 O O    . ASN A 1 403 ? 6.827   -39.237 -0.189  1.00 25.18  ? 367 ASN A O    1 
ATOM   5527 C CB   . ASN A 1 403 ? 6.966   -41.805 -2.175  1.00 37.84  ? 367 ASN A CB   1 
ATOM   5528 C CG   . ASN A 1 403 ? 7.924   -42.825 -2.748  1.00 38.96  ? 367 ASN A CG   1 
ATOM   5529 O OD1  . ASN A 1 403 ? 8.633   -43.516 -2.019  1.00 43.96  ? 367 ASN A OD1  1 
ATOM   5530 N ND2  . ASN A 1 403 ? 7.991   -42.880 -4.060  1.00 41.04  ? 367 ASN A ND2  1 
ATOM   5531 H H    . ASN A 1 403 ? 8.872   -40.678 -0.720  1.00 38.90  ? 367 ASN A H    1 
ATOM   5532 H HA   . ASN A 1 403 ? 7.626   -40.095 -3.078  1.00 34.75  ? 367 ASN A HA   1 
ATOM   5533 H HB2  . ASN A 1 403 ? 6.749   -42.070 -1.267  1.00 45.40  ? 367 ASN A HB2  1 
ATOM   5534 H HB3  . ASN A 1 403 ? 6.164   -41.802 -2.720  1.00 45.40  ? 367 ASN A HB3  1 
ATOM   5535 H HD21 . ASN A 1 403 ? 8.520   -43.442 -4.441  1.00 49.24  ? 367 ASN A HD21 1 
ATOM   5536 H HD22 . ASN A 1 403 ? 7.507   -42.354 -4.538  1.00 49.24  ? 367 ASN A HD22 1 
ATOM   5537 N N    . ALA A 1 404 ? 5.707   -38.872 -2.112  1.00 28.28  ? 368 ALA A N    1 
ATOM   5538 C CA   . ALA A 1 404 ? 4.745   -38.001 -1.479  1.00 28.73  ? 368 ALA A CA   1 
ATOM   5539 C C    . ALA A 1 404 ? 3.464   -37.984 -2.287  1.00 33.42  ? 368 ALA A C    1 
ATOM   5540 O O    . ALA A 1 404 ? 3.414   -38.397 -3.453  1.00 31.65  ? 368 ALA A O    1 
ATOM   5541 C CB   . ALA A 1 404 ? 5.313   -36.573 -1.319  1.00 23.29  ? 368 ALA A CB   1 
ATOM   5542 H H    . ALA A 1 404 ? 5.595   -38.979 -2.958  1.00 33.93  ? 368 ALA A H    1 
ATOM   5543 H HA   . ALA A 1 404 ? 4.527   -38.348 -0.600  1.00 34.47  ? 368 ALA A HA   1 
ATOM   5544 H HB1  . ALA A 1 404 ? 4.727   -36.064 -0.737  1.00 27.93  ? 368 ALA A HB1  1 
ATOM   5545 H HB2  . ALA A 1 404 ? 6.200   -36.627 -0.931  1.00 27.93  ? 368 ALA A HB2  1 
ATOM   5546 H HB3  . ALA A 1 404 ? 5.359   -36.152 -2.192  1.00 27.93  ? 368 ALA A HB3  1 
ATOM   5547 N N    . LYS A 1 405 ? 2.424   -37.494 -1.635  1.00 26.07  ? 369 LYS A N    1 
ATOM   5548 C CA   . LYS A 1 405 ? 1.121   -37.309 -2.238  1.00 31.14  ? 369 LYS A CA   1 
ATOM   5549 C C    . LYS A 1 405 ? 0.475   -36.151 -1.502  1.00 26.14  ? 369 LYS A C    1 
ATOM   5550 O O    . LYS A 1 405 ? 0.350   -36.183 -0.270  1.00 22.79  ? 369 LYS A O    1 
ATOM   5551 C CB   . LYS A 1 405 ? 0.266   -38.573 -2.137  1.00 28.97  ? 369 LYS A CB   1 
ATOM   5552 C CG   . LYS A 1 405 ? -1.134  -38.431 -2.719  1.00 39.54  ? 369 LYS A CG   1 
ATOM   5553 C CD   . LYS A 1 405 ? -1.098  -38.501 -4.241  1.00 44.35  ? 369 LYS A CD   1 
ATOM   5554 C CE   . LYS A 1 405 ? -2.498  -38.526 -4.853  1.00 55.45  ? 369 LYS A CE   1 
ATOM   5555 N NZ   . LYS A 1 405 ? -3.550  -38.152 -3.876  1.00 56.30  ? 369 LYS A NZ   1 
ATOM   5556 H H    . LYS A 1 405 ? 2.450   -37.252 -0.810  1.00 31.27  ? 369 LYS A H    1 
ATOM   5557 H HA   . LYS A 1 405 ? 1.205   -37.098 -3.181  1.00 37.36  ? 369 LYS A HA   1 
ATOM   5558 H HB2  . LYS A 1 405 ? 0.712   -39.288 -2.617  1.00 34.76  ? 369 LYS A HB2  1 
ATOM   5559 H HB3  . LYS A 1 405 ? 0.172   -38.809 -1.201  1.00 34.76  ? 369 LYS A HB3  1 
ATOM   5560 H HG2  . LYS A 1 405 ? -1.696  -39.150 -2.391  1.00 47.44  ? 369 LYS A HG2  1 
ATOM   5561 H HG3  . LYS A 1 405 ? -1.507  -37.574 -2.460  1.00 47.44  ? 369 LYS A HG3  1 
ATOM   5562 H HD2  . LYS A 1 405 ? -0.633  -37.723 -4.585  1.00 53.21  ? 369 LYS A HD2  1 
ATOM   5563 H HD3  . LYS A 1 405 ? -0.637  -39.311 -4.512  1.00 53.21  ? 369 LYS A HD3  1 
ATOM   5564 H HE2  . LYS A 1 405 ? -2.534  -37.896 -5.590  1.00 66.53  ? 369 LYS A HE2  1 
ATOM   5565 H HE3  . LYS A 1 405 ? -2.689  -39.422 -5.173  1.00 66.53  ? 369 LYS A HE3  1 
ATOM   5566 H HZ1  . LYS A 1 405 ? -4.344  -38.131 -4.277  1.00 67.56  ? 369 LYS A HZ1  1 
ATOM   5567 H HZ2  . LYS A 1 405 ? -3.576  -38.746 -3.214  1.00 67.56  ? 369 LYS A HZ2  1 
ATOM   5568 H HZ3  . LYS A 1 405 ? -3.377  -37.348 -3.536  1.00 67.56  ? 369 LYS A HZ3  1 
ATOM   5569 N N    . ILE A 1 406 ? 0.124   -35.119 -2.255  1.00 25.89  ? 370 ILE A N    1 
ATOM   5570 C CA   . ILE A 1 406 ? -0.723  -34.042 -1.778  1.00 21.97  ? 370 ILE A CA   1 
ATOM   5571 C C    . ILE A 1 406 ? -2.090  -34.244 -2.397  1.00 24.53  ? 370 ILE A C    1 
ATOM   5572 O O    . ILE A 1 406 ? -2.217  -34.319 -3.627  1.00 30.04  ? 370 ILE A O    1 
ATOM   5573 C CB   . ILE A 1 406 ? -0.159  -32.663 -2.140  1.00 23.71  ? 370 ILE A CB   1 
ATOM   5574 C CG1  . ILE A 1 406 ? 1.263   -32.537 -1.654  1.00 22.19  ? 370 ILE A CG1  1 
ATOM   5575 C CG2  . ILE A 1 406 ? -1.061  -31.576 -1.564  1.00 29.99  ? 370 ILE A CG2  1 
ATOM   5576 C CD1  . ILE A 1 406 ? 2.004   -31.305 -2.229  1.00 25.96  ? 370 ILE A CD1  1 
ATOM   5577 H H    . ILE A 1 406 ? 0.373   -35.019 -3.071  1.00 31.06  ? 370 ILE A H    1 
ATOM   5578 H HA   . ILE A 1 406 ? -0.798  -34.092 -0.813  1.00 26.36  ? 370 ILE A HA   1 
ATOM   5579 H HB   . ILE A 1 406 ? -0.142  -32.560 -3.105  1.00 28.45  ? 370 ILE A HB   1 
ATOM   5580 H HG12 . ILE A 1 406 ? 1.258   -32.457 -0.688  1.00 26.62  ? 370 ILE A HG12 1 
ATOM   5581 H HG13 . ILE A 1 406 ? 1.756   -33.330 -1.919  1.00 26.62  ? 370 ILE A HG13 1 
ATOM   5582 H HG21 . ILE A 1 406 ? -0.643  -30.712 -1.704  1.00 35.97  ? 370 ILE A HG21 1 
ATOM   5583 H HG22 . ILE A 1 406 ? -1.919  -31.606 -2.014  1.00 35.97  ? 370 ILE A HG22 1 
ATOM   5584 H HG23 . ILE A 1 406 ? -1.179  -31.736 -0.614  1.00 35.97  ? 370 ILE A HG23 1 
ATOM   5585 H HD11 . ILE A 1 406 ? 2.954   -31.398 -2.057  1.00 31.14  ? 370 ILE A HD11 1 
ATOM   5586 H HD12 . ILE A 1 406 ? 1.844   -31.257 -3.184  1.00 31.14  ? 370 ILE A HD12 1 
ATOM   5587 H HD13 . ILE A 1 406 ? 1.667   -30.504 -1.797  1.00 31.14  ? 370 ILE A HD13 1 
ATOM   5588 N N    . THR A 1 407 ? -3.100  -34.358 -1.564  1.00 29.11  ? 371 THR A N    1 
ATOM   5589 C CA   . THR A 1 407 ? -4.473  -34.482 -2.034  1.00 25.72  ? 371 THR A CA   1 
ATOM   5590 C C    . THR A 1 407 ? -5.127  -33.103 -1.951  1.00 24.25  ? 371 THR A C    1 
ATOM   5591 O O    . THR A 1 407 ? -5.435  -32.610 -0.860  1.00 26.32  ? 371 THR A O    1 
ATOM   5592 C CB   . THR A 1 407 ? -5.241  -35.534 -1.235  1.00 29.01  ? 371 THR A CB   1 
ATOM   5593 O OG1  . THR A 1 407 ? -4.520  -36.768 -1.295  1.00 30.21  ? 371 THR A OG1  1 
ATOM   5594 C CG2  . THR A 1 407 ? -6.610  -35.741 -1.814  1.00 32.46  ? 371 THR A CG2  1 
ATOM   5595 H H    . THR A 1 407 ? -3.021  -34.366 -0.708  1.00 34.92  ? 371 THR A H    1 
ATOM   5596 H HA   . THR A 1 407 ? -4.479  -34.767 -2.961  1.00 30.85  ? 371 THR A HA   1 
ATOM   5597 H HB   . THR A 1 407 ? -5.341  -35.245 -0.315  1.00 34.80  ? 371 THR A HB   1 
ATOM   5598 H HG1  . THR A 1 407 ? -4.903  -37.348 -0.823  1.00 36.24  ? 371 THR A HG1  1 
ATOM   5599 H HG21 . THR A 1 407 ? -7.080  -36.429 -1.316  1.00 38.95  ? 371 THR A HG21 1 
ATOM   5600 H HG22 . THR A 1 407 ? -7.118  -34.916 -1.767  1.00 38.95  ? 371 THR A HG22 1 
ATOM   5601 H HG23 . THR A 1 407 ? -6.540  -36.016 -2.741  1.00 38.95  ? 371 THR A HG23 1 
ATOM   5602 N N    . TRP A 1 408 ? -5.301  -32.484 -3.110  1.00 26.89  ? 372 TRP A N    1 
ATOM   5603 C CA   . TRP A 1 408 ? -5.934  -31.173 -3.205  1.00 31.19  ? 372 TRP A CA   1 
ATOM   5604 C C    . TRP A 1 408 ? -7.442  -31.324 -3.116  1.00 33.05  ? 372 TRP A C    1 
ATOM   5605 O O    . TRP A 1 408 ? -8.054  -31.998 -3.951  1.00 41.56  ? 372 TRP A O    1 
ATOM   5606 C CB   . TRP A 1 408 ? -5.526  -30.506 -4.508  1.00 32.92  ? 372 TRP A CB   1 
ATOM   5607 C CG   . TRP A 1 408 ? -4.055  -30.440 -4.653  1.00 29.09  ? 372 TRP A CG   1 
ATOM   5608 C CD1  . TRP A 1 408 ? -3.254  -31.305 -5.325  1.00 31.68  ? 372 TRP A CD1  1 
ATOM   5609 C CD2  . TRP A 1 408 ? -3.191  -29.458 -4.073  1.00 28.20  ? 372 TRP A CD2  1 
ATOM   5610 N NE1  . TRP A 1 408 ? -1.943  -30.916 -5.221  1.00 29.59  ? 372 TRP A NE1  1 
ATOM   5611 C CE2  . TRP A 1 408 ? -1.879  -29.786 -4.448  1.00 28.27  ? 372 TRP A CE2  1 
ATOM   5612 C CE3  . TRP A 1 408 ? -3.404  -28.343 -3.265  1.00 26.69  ? 372 TRP A CE3  1 
ATOM   5613 C CZ2  . TRP A 1 408 ? -0.777  -29.021 -4.055  1.00 31.37  ? 372 TRP A CZ2  1 
ATOM   5614 C CZ3  . TRP A 1 408 ? -2.315  -27.584 -2.884  1.00 23.29  ? 372 TRP A CZ3  1 
ATOM   5615 C CH2  . TRP A 1 408 ? -1.023  -27.929 -3.271  1.00 24.37  ? 372 TRP A CH2  1 
ATOM   5616 H H    . TRP A 1 408 ? -5.058  -32.805 -3.870  1.00 32.26  ? 372 TRP A H    1 
ATOM   5617 H HA   . TRP A 1 408 ? -5.649  -30.613 -2.466  1.00 37.41  ? 372 TRP A HA   1 
ATOM   5618 H HB2  . TRP A 1 408 ? -5.883  -31.014 -5.253  1.00 39.50  ? 372 TRP A HB2  1 
ATOM   5619 H HB3  . TRP A 1 408 ? -5.874  -29.601 -4.526  1.00 39.50  ? 372 TRP A HB3  1 
ATOM   5620 H HD1  . TRP A 1 408 ? -3.551  -32.055 -5.790  1.00 38.00  ? 372 TRP A HD1  1 
ATOM   5621 H HE1  . TRP A 1 408 ? -1.272  -31.315 -5.582  1.00 35.50  ? 372 TRP A HE1  1 
ATOM   5622 H HE3  . TRP A 1 408 ? -4.262  -28.115 -2.988  1.00 32.01  ? 372 TRP A HE3  1 
ATOM   5623 H HZ2  . TRP A 1 408 ? 0.087   -29.246 -4.316  1.00 37.63  ? 372 TRP A HZ2  1 
ATOM   5624 H HZ3  . TRP A 1 408 ? -2.448  -26.828 -2.360  1.00 27.94  ? 372 TRP A HZ3  1 
ATOM   5625 H HH2  . TRP A 1 408 ? -0.310  -27.403 -2.988  1.00 29.24  ? 372 TRP A HH2  1 
ATOM   5626 N N    . ARG A 1 409 ? -8.023  -30.750 -2.078  1.00 31.82  ? 373 ARG A N    1 
ATOM   5627 C CA   . ARG A 1 409 ? -9.465  -30.718 -1.897  1.00 35.38  ? 373 ARG A CA   1 
ATOM   5628 C C    . ARG A 1 409 ? -10.025 -29.439 -2.518  1.00 38.76  ? 373 ARG A C    1 
ATOM   5629 O O    . ARG A 1 409 ? -9.381  -28.376 -2.522  1.00 33.23  ? 373 ARG A O    1 
ATOM   5630 C CB   . ARG A 1 409 ? -9.828  -30.778 -0.415  1.00 36.74  ? 373 ARG A CB   1 
ATOM   5631 C CG   . ARG A 1 409 ? -9.526  -32.132 0.267   1.00 60.99  ? 373 ARG A CG   1 
ATOM   5632 C CD   . ARG A 1 409 ? -8.427  -32.005 1.347   1.00 52.84  ? 373 ARG A CD   1 
ATOM   5633 N NE   . ARG A 1 409 ? -8.847  -31.094 2.410   1.00 56.90  ? 373 ARG A NE   1 
ATOM   5634 C CZ   . ARG A 1 409 ? -9.912  -31.271 3.189   1.00 73.22  ? 373 ARG A CZ   1 
ATOM   5635 N NH1  . ARG A 1 409 ? -10.585 -32.414 3.196   1.00 78.88  ? 373 ARG A NH1  1 
ATOM   5636 N NH2  . ARG A 1 409 ? -10.316 -30.272 3.975   1.00 54.39  ? 373 ARG A NH2  1 
ATOM   5637 O OXT  . ARG A 1 409 ? -11.145 -29.445 -3.016  1.00 38.87  ? 373 ARG A OXT  1 
ATOM   5638 H H    . ARG A 1 409 ? -7.593  -30.360 -1.444  1.00 38.17  ? 373 ARG A H    1 
ATOM   5639 H HA   . ARG A 1 409 ? -9.869  -31.488 -2.327  1.00 42.45  ? 373 ARG A HA   1 
ATOM   5640 H HB2  . ARG A 1 409 ? -9.323  -30.095 0.054   1.00 44.08  ? 373 ARG A HB2  1 
ATOM   5641 H HB3  . ARG A 1 409 ? -10.779 -30.609 -0.322  1.00 44.08  ? 373 ARG A HB3  1 
ATOM   5642 H HG2  . ARG A 1 409 ? -10.333 -32.462 0.693   1.00 73.17  ? 373 ARG A HG2  1 
ATOM   5643 H HG3  . ARG A 1 409 ? -9.222  -32.765 -0.402  1.00 73.17  ? 373 ARG A HG3  1 
ATOM   5644 H HD2  . ARG A 1 409 ? -8.254  -32.876 1.738   1.00 63.40  ? 373 ARG A HD2  1 
ATOM   5645 H HD3  . ARG A 1 409 ? -7.616  -31.655 0.945   1.00 63.40  ? 373 ARG A HD3  1 
ATOM   5646 H HE   . ARG A 1 409 ? -8.371  -30.391 2.543   1.00 68.27  ? 373 ARG A HE   1 
ATOM   5647 H HH11 . ARG A 1 409 ? -10.336 -33.062 2.689   1.00 94.64  ? 373 ARG A HH11 1 
ATOM   5648 H HH12 . ARG A 1 409 ? -11.270 -32.506 3.708   1.00 94.64  ? 373 ARG A HH12 1 
ATOM   5649 H HH21 . ARG A 1 409 ? -9.890  -29.525 3.974   1.00 65.26  ? 373 ARG A HH21 1 
ATOM   5650 H HH22 . ARG A 1 409 ? -11.003 -30.375 4.482   1.00 65.26  ? 373 ARG A HH22 1 
HETATM 5651 O O    . HOH B 2 .   ? 14.321  -10.701 13.632  1.00 30.53  ? 401 HOH A O    1 
HETATM 5652 O O    . HOH B 2 .   ? 17.619  -35.839 -19.748 1.00 53.54  ? 402 HOH A O    1 
HETATM 5653 O O    . HOH B 2 .   ? 46.249  -15.363 -6.794  1.00 37.38  ? 403 HOH A O    1 
HETATM 5654 O O    . HOH B 2 .   ? 36.478  -5.553  -13.905 1.00 37.77  ? 404 HOH A O    1 
HETATM 5655 O O    . HOH B 2 .   ? 3.263   -7.549  -23.434 1.00 38.69  ? 405 HOH A O    1 
HETATM 5656 O O    . HOH B 2 .   ? 12.153  -21.050 19.479  1.00 35.15  ? 406 HOH A O    1 
HETATM 5657 O O    . HOH B 2 .   ? 29.328  5.830   -6.885  1.00 40.68  ? 407 HOH A O    1 
HETATM 5658 O O    . HOH B 2 .   ? 18.469  -41.486 10.748  1.00 37.34  ? 408 HOH A O    1 
HETATM 5659 O O    . HOH B 2 .   ? 14.417  3.146   2.484   1.00 31.12  ? 409 HOH A O    1 
HETATM 5660 O O    . HOH B 2 .   ? 25.143  6.768   -6.822  1.00 27.14  ? 410 HOH A O    1 
HETATM 5661 O O    . HOH B 2 .   ? 32.889  -0.479  10.860  1.00 27.06  ? 411 HOH A O    1 
HETATM 5662 O O    . HOH B 2 .   ? 27.032  -24.028 4.514   1.00 47.82  ? 412 HOH A O    1 
HETATM 5663 O O    . HOH B 2 .   ? -5.671  -21.682 -7.352  1.00 39.54  ? 413 HOH A O    1 
HETATM 5664 O O    . HOH B 2 .   ? 51.377  -11.326 -0.581  1.00 55.13  ? 414 HOH A O    1 
HETATM 5665 O O    . HOH B 2 .   ? 46.145  -16.097 4.798   1.00 45.04  ? 415 HOH A O    1 
HETATM 5666 O O    . HOH B 2 .   ? 17.852  -19.483 17.066  1.00 44.50  ? 416 HOH A O    1 
HETATM 5667 O O    . HOH B 2 .   ? -10.580 -26.131 9.161   1.00 35.04  ? 417 HOH A O    1 
HETATM 5668 O O    . HOH B 2 .   ? 47.734  -9.484  -7.064  1.00 40.99  ? 418 HOH A O    1 
HETATM 5669 O O    . HOH B 2 .   ? 16.486  -25.439 14.977  1.00 32.72  ? 419 HOH A O    1 
HETATM 5670 O O    . HOH B 2 .   ? 26.889  -12.495 -21.773 1.00 39.09  ? 420 HOH A O    1 
HETATM 5671 O O    . HOH B 2 .   ? 22.653  -24.900 -8.537  1.00 42.02  ? 421 HOH A O    1 
HETATM 5672 O O    . HOH B 2 .   ? -7.232  -14.440 -2.009  1.00 27.62  ? 422 HOH A O    1 
HETATM 5673 O O    . HOH B 2 .   ? 17.779  -28.710 -3.770  1.00 25.39  ? 423 HOH A O    1 
HETATM 5674 O O    . HOH B 2 .   ? 21.731  3.596   9.723   1.00 38.28  ? 424 HOH A O    1 
HETATM 5675 O O    . HOH B 2 .   ? 25.545  -21.418 6.374   1.00 32.78  ? 425 HOH A O    1 
HETATM 5676 O O    . HOH B 2 .   ? 27.469  3.873   -8.402  1.00 36.66  ? 426 HOH A O    1 
HETATM 5677 O O    . HOH B 2 .   ? 20.242  -26.451 10.916  1.00 33.23  ? 427 HOH A O    1 
HETATM 5678 O O    . HOH B 2 .   ? 17.664  -21.207 6.681   1.00 24.18  ? 428 HOH A O    1 
HETATM 5679 O O    . HOH B 2 .   ? 5.210   -6.139  -24.088 1.00 42.10  ? 429 HOH A O    1 
HETATM 5680 O O    . HOH B 2 .   ? -6.951  -31.214 5.049   1.00 30.40  ? 430 HOH A O    1 
HETATM 5681 O O    . HOH B 2 .   ? 0.449   -17.571 -0.736  1.00 24.47  ? 431 HOH A O    1 
HETATM 5682 O O    . HOH B 2 .   ? 19.217  -36.819 -0.109  1.00 39.73  ? 432 HOH A O    1 
HETATM 5683 O O    . HOH B 2 .   ? 29.093  -10.150 -19.499 1.00 39.59  ? 433 HOH A O    1 
HETATM 5684 O O    . HOH B 2 .   ? 16.699  -7.926  11.711  1.00 31.38  ? 434 HOH A O    1 
HETATM 5685 O O    . HOH B 2 .   ? -2.276  -17.009 -4.625  1.00 37.93  ? 435 HOH A O    1 
HETATM 5686 O O    . HOH B 2 .   ? 14.065  -23.469 -19.019 1.00 36.70  ? 436 HOH A O    1 
HETATM 5687 O O    . HOH B 2 .   ? 3.336   -13.129 -19.209 1.00 39.68  ? 437 HOH A O    1 
HETATM 5688 O O    . HOH B 2 .   ? 20.732  -26.049 -13.585 1.00 47.52  ? 438 HOH A O    1 
HETATM 5689 O O    . HOH B 2 .   ? 5.218   -14.461 -2.550  1.00 21.65  ? 439 HOH A O    1 
HETATM 5690 O O    . HOH B 2 .   ? 16.609  3.371   -4.115  1.00 35.62  ? 440 HOH A O    1 
HETATM 5691 O O    . HOH B 2 .   ? 4.321   -13.888 18.649  1.00 36.16  ? 441 HOH A O    1 
HETATM 5692 O O    . HOH B 2 .   ? 29.611  2.123   -8.722  1.00 30.31  ? 442 HOH A O    1 
HETATM 5693 O O    . HOH B 2 .   ? -3.613  -14.232 -1.759  1.00 40.10  ? 443 HOH A O    1 
HETATM 5694 O O    . HOH B 2 .   ? 46.271  -23.323 -2.678  1.00 24.76  ? 444 HOH A O    1 
HETATM 5695 O O    . HOH B 2 .   ? 9.917   -30.459 13.248  1.00 26.55  ? 445 HOH A O    1 
HETATM 5696 O O    . HOH B 2 .   ? 21.783  -8.905  -24.541 1.00 37.22  ? 446 HOH A O    1 
HETATM 5697 O O    . HOH B 2 .   ? 15.487  -2.739  8.265   1.00 34.86  ? 447 HOH A O    1 
HETATM 5698 O O    . HOH B 2 .   ? 11.657  -10.881 14.809  1.00 30.14  ? 448 HOH A O    1 
HETATM 5699 O O    . HOH B 2 .   ? 1.346   -19.896 -5.136  1.00 21.50  ? 449 HOH A O    1 
HETATM 5700 O O    . HOH B 2 .   ? 12.818  -45.965 11.804  1.00 43.39  ? 450 HOH A O    1 
HETATM 5701 O O    . HOH B 2 .   ? 8.258   -37.619 -7.197  1.00 39.30  ? 451 HOH A O    1 
HETATM 5702 O O    . HOH B 2 .   ? 3.134   -26.977 -16.381 1.00 48.15  ? 452 HOH A O    1 
HETATM 5703 O O    . HOH B 2 .   ? 41.202  -21.970 -4.378  1.00 38.32  ? 453 HOH A O    1 
HETATM 5704 O O    . HOH B 2 .   ? 37.173  -11.398 -7.536  1.00 20.51  ? 454 HOH A O    1 
HETATM 5705 O O    . HOH B 2 .   ? 14.699  -19.509 -12.242 1.00 22.72  ? 455 HOH A O    1 
HETATM 5706 O O    . HOH B 2 .   ? 52.921  -17.560 2.882   1.00 42.92  ? 456 HOH A O    1 
HETATM 5707 O O    . HOH B 2 .   ? 45.722  -19.919 -4.252  1.00 30.75  ? 457 HOH A O    1 
HETATM 5708 O O    . HOH B 2 .   ? 0.268   -32.883 -6.080  1.00 34.09  ? 458 HOH A O    1 
HETATM 5709 O O    . HOH B 2 .   ? 13.995  -8.056  -26.409 1.00 35.80  ? 459 HOH A O    1 
HETATM 5710 O O    . HOH B 2 .   ? 16.923  -29.685 15.411  1.00 43.20  ? 460 HOH A O    1 
HETATM 5711 O O    . HOH B 2 .   ? -2.450  -11.685 4.854   1.00 26.15  ? 461 HOH A O    1 
HETATM 5712 O O    . HOH B 2 .   ? 15.760  -20.082 -9.989  1.00 18.11  ? 462 HOH A O    1 
HETATM 5713 O O    . HOH B 2 .   ? 42.005  -10.477 8.792   1.00 39.31  ? 463 HOH A O    1 
HETATM 5714 O O    . HOH B 2 .   ? 8.818   -34.302 15.077  1.00 31.91  ? 464 HOH A O    1 
HETATM 5715 O O    . HOH B 2 .   ? 41.483  -13.573 -2.178  1.00 20.75  ? 465 HOH A O    1 
HETATM 5716 O O    . HOH B 2 .   ? 1.758   -32.065 -11.973 1.00 37.58  ? 466 HOH A O    1 
HETATM 5717 O O    . HOH B 2 .   ? 11.867  -24.236 18.438  1.00 31.29  ? 467 HOH A O    1 
HETATM 5718 O O    . HOH B 2 .   ? 23.957  -10.078 -23.865 1.00 40.28  ? 468 HOH A O    1 
HETATM 5719 O O    . HOH B 2 .   ? 37.083  -0.017  5.257   1.00 21.83  ? 469 HOH A O    1 
HETATM 5720 O O    . HOH B 2 .   ? 18.201  -27.594 8.302   1.00 26.53  ? 470 HOH A O    1 
HETATM 5721 O O    . HOH B 2 .   ? 20.101  -23.951 -14.856 1.00 41.23  ? 471 HOH A O    1 
HETATM 5722 O O    . HOH B 2 .   ? -8.148  -16.414 1.901   1.00 27.14  ? 472 HOH A O    1 
HETATM 5723 O O    . HOH B 2 .   ? 45.479  -22.481 0.966   1.00 28.90  ? 473 HOH A O    1 
HETATM 5724 O O    . HOH B 2 .   ? -2.220  -36.654 4.708   1.00 29.18  ? 474 HOH A O    1 
HETATM 5725 O O    . HOH B 2 .   ? 10.507  -16.593 -21.863 1.00 29.95  ? 475 HOH A O    1 
HETATM 5726 O O    . HOH B 2 .   ? 20.713  -8.240  -7.255  1.00 16.88  ? 476 HOH A O    1 
HETATM 5727 O O    . HOH B 2 .   ? 6.403   -41.577 10.912  1.00 33.02  ? 477 HOH A O    1 
HETATM 5728 O O    . HOH B 2 .   ? 4.652   -37.384 -6.229  1.00 35.04  ? 478 HOH A O    1 
HETATM 5729 O O    . HOH B 2 .   ? 30.552  -18.348 10.061  1.00 27.20  ? 479 HOH A O    1 
HETATM 5730 O O    . HOH B 2 .   ? -6.756  -30.322 -7.891  1.00 45.51  ? 480 HOH A O    1 
HETATM 5731 O O    . HOH B 2 .   ? 19.013  -16.870 -21.627 1.00 33.25  ? 481 HOH A O    1 
HETATM 5732 O O    . HOH B 2 .   ? -3.138  -22.133 10.812  1.00 29.01  ? 482 HOH A O    1 
HETATM 5733 O O    . HOH B 2 .   ? 12.448  0.997   -5.686  1.00 34.33  ? 483 HOH A O    1 
HETATM 5734 O O    . HOH B 2 .   ? 10.057  -36.241 15.746  1.00 39.78  ? 484 HOH A O    1 
HETATM 5735 O O    . HOH B 2 .   ? 15.363  -9.374  -22.974 1.00 33.22  ? 485 HOH A O    1 
HETATM 5736 O O    . HOH B 2 .   ? 14.603  -39.963 -4.381  1.00 50.09  ? 486 HOH A O    1 
HETATM 5737 O O    . HOH B 2 .   ? 13.103  -9.227  11.619  1.00 23.09  ? 487 HOH A O    1 
HETATM 5738 O O    . HOH B 2 .   ? 6.846   -8.338  15.038  1.00 33.33  ? 488 HOH A O    1 
HETATM 5739 O O    . HOH B 2 .   ? 8.351   -46.742 12.665  1.00 44.03  ? 489 HOH A O    1 
HETATM 5740 O O    . HOH B 2 .   ? 13.772  -12.303 16.959  1.00 26.09  ? 490 HOH A O    1 
HETATM 5741 O O    . HOH B 2 .   ? 0.652   -33.375 -8.536  1.00 33.05  ? 491 HOH A O    1 
HETATM 5742 O O    . HOH B 2 .   ? 8.384   -10.329 12.839  1.00 23.82  ? 492 HOH A O    1 
HETATM 5743 O O    . HOH B 2 .   ? 8.894   -1.996  -0.411  1.00 42.54  ? 493 HOH A O    1 
HETATM 5744 O O    . HOH B 2 .   ? 31.534  0.163   -3.005  1.00 28.48  ? 494 HOH A O    1 
HETATM 5745 O O    . HOH B 2 .   ? 27.296  -12.793 17.981  1.00 40.14  ? 495 HOH A O    1 
HETATM 5746 O O    . HOH B 2 .   ? -0.085  -10.192 -4.135  1.00 39.46  ? 496 HOH A O    1 
HETATM 5747 O O    . HOH B 2 .   ? 12.680  -20.552 -16.316 1.00 24.88  ? 497 HOH A O    1 
HETATM 5748 O O    . HOH B 2 .   ? 25.870  -22.349 -0.789  1.00 28.72  ? 498 HOH A O    1 
HETATM 5749 O O    . HOH B 2 .   ? 35.600  -9.476  15.306  1.00 38.59  ? 499 HOH A O    1 
HETATM 5750 O O    . HOH B 2 .   ? 8.305   -26.186 10.927  1.00 17.35  ? 500 HOH A O    1 
HETATM 5751 O O    . HOH B 2 .   ? 12.211  -26.106 16.438  1.00 27.43  ? 501 HOH A O    1 
HETATM 5752 O O    . HOH B 2 .   ? -1.170  -19.620 9.843   1.00 33.30  ? 502 HOH A O    1 
HETATM 5753 O O    . HOH B 2 .   ? 42.862  -3.834  5.105   1.00 26.22  ? 503 HOH A O    1 
HETATM 5754 O O    . HOH B 2 .   ? 4.768   -29.932 -11.753 1.00 31.95  ? 504 HOH A O    1 
HETATM 5755 O O    . HOH B 2 .   ? 20.422  -19.435 15.677  1.00 49.46  ? 505 HOH A O    1 
HETATM 5756 O O    . HOH B 2 .   ? 14.519  -35.549 -0.180  1.00 29.95  ? 506 HOH A O    1 
HETATM 5757 O O    . HOH B 2 .   ? 6.483   -15.602 15.808  1.00 25.77  ? 507 HOH A O    1 
HETATM 5758 O O    . HOH B 2 .   ? 0.291   -12.670 10.997  1.00 33.74  ? 508 HOH A O    1 
HETATM 5759 O O    . HOH B 2 .   ? -5.840  -19.026 2.727   1.00 19.92  ? 509 HOH A O    1 
HETATM 5760 O O    . HOH B 2 .   ? 6.884   -3.556  -15.744 1.00 34.76  ? 510 HOH A O    1 
HETATM 5761 O O    . HOH B 2 .   ? -0.737  -36.701 -6.844  1.00 46.41  ? 511 HOH A O    1 
HETATM 5762 O O    . HOH B 2 .   ? 29.338  -8.345  -7.883  1.00 18.04  ? 512 HOH A O    1 
HETATM 5763 O O    . HOH B 2 .   ? -0.306  -24.390 -3.909  1.00 21.81  ? 513 HOH A O    1 
HETATM 5764 O O    . HOH B 2 .   ? 22.670  -8.251  -9.370  1.00 16.84  ? 514 HOH A O    1 
HETATM 5765 O O    . HOH B 2 .   ? 28.823  -5.383  -21.261 1.00 35.87  ? 515 HOH A O    1 
HETATM 5766 O O    . HOH B 2 .   ? 13.559  -18.908 17.751  1.00 31.07  ? 516 HOH A O    1 
HETATM 5767 O O    . HOH B 2 .   ? 21.726  -36.896 6.668   1.00 34.82  ? 517 HOH A O    1 
HETATM 5768 O O    . HOH B 2 .   ? 33.535  -0.267  -5.030  1.00 25.58  ? 518 HOH A O    1 
HETATM 5769 O O    . HOH B 2 .   ? 28.620  -18.588 -3.100  1.00 27.61  ? 519 HOH A O    1 
HETATM 5770 O O    . HOH B 2 .   ? -0.036  -10.785 6.145   1.00 35.02  ? 520 HOH A O    1 
HETATM 5771 O O    . HOH B 2 .   ? 47.356  -4.038  -0.706  1.00 29.08  ? 521 HOH A O    1 
HETATM 5772 O O    . HOH B 2 .   ? -7.390  -35.042 5.093   1.00 31.33  ? 522 HOH A O    1 
HETATM 5773 O O    . HOH B 2 .   ? 12.118  -5.971  -24.080 1.00 43.41  ? 523 HOH A O    1 
HETATM 5774 O O    . HOH B 2 .   ? 30.163  2.016   10.350  1.00 34.90  ? 524 HOH A O    1 
HETATM 5775 O O    . HOH B 2 .   ? 12.336  -36.037 7.376   1.00 22.48  ? 525 HOH A O    1 
HETATM 5776 O O    . HOH B 2 .   ? 11.569  -0.166  2.426   1.00 34.41  ? 526 HOH A O    1 
HETATM 5777 O O    . HOH B 2 .   ? 6.592   -35.582 -6.952  1.00 28.29  ? 527 HOH A O    1 
HETATM 5778 O O    . HOH B 2 .   ? 18.946  6.662   -10.806 1.00 44.20  ? 528 HOH A O    1 
HETATM 5779 O O    . HOH B 2 .   ? 20.456  -24.529 4.724   1.00 24.29  ? 529 HOH A O    1 
HETATM 5780 O O    . HOH B 2 .   ? 37.872  -11.948 -10.904 1.00 28.88  ? 530 HOH A O    1 
HETATM 5781 O O    . HOH B 2 .   ? -2.563  -35.204 -6.155  1.00 42.04  ? 531 HOH A O    1 
HETATM 5782 O O    . HOH B 2 .   ? 12.664  -1.138  -15.469 1.00 25.65  ? 532 HOH A O    1 
HETATM 5783 O O    . HOH B 2 .   ? 5.986   -39.443 -4.739  1.00 37.07  ? 533 HOH A O    1 
HETATM 5784 O O    . HOH B 2 .   ? -5.258  -39.351 -1.606  1.00 44.28  ? 534 HOH A O    1 
HETATM 5785 O O    . HOH B 2 .   ? 30.933  -15.447 4.636   1.00 26.63  ? 535 HOH A O    1 
HETATM 5786 O O    . HOH B 2 .   ? 15.123  -6.577  11.823  1.00 33.44  ? 536 HOH A O    1 
HETATM 5787 O O    . HOH B 2 .   ? 14.963  0.265   -9.369  1.00 20.72  ? 537 HOH A O    1 
HETATM 5788 O O    . HOH B 2 .   ? 3.923   -6.618  7.238   1.00 29.99  ? 538 HOH A O    1 
HETATM 5789 O O    . HOH B 2 .   ? 33.103  -4.924  12.495  1.00 26.15  ? 539 HOH A O    1 
HETATM 5790 O O    . HOH B 2 .   ? 17.389  -34.563 12.114  1.00 28.43  ? 540 HOH A O    1 
HETATM 5791 O O    . HOH B 2 .   ? 33.101  -13.754 4.215   1.00 21.13  ? 541 HOH A O    1 
HETATM 5792 O O    . HOH B 2 .   ? 45.224  -9.338  0.969   1.00 29.42  ? 542 HOH A O    1 
HETATM 5793 O O    . HOH B 2 .   ? 24.684  -8.287  -7.317  1.00 18.19  ? 543 HOH A O    1 
HETATM 5794 O O    . HOH B 2 .   ? 21.770  -17.007 17.199  1.00 26.63  ? 544 HOH A O    1 
HETATM 5795 O O    . HOH B 2 .   ? 14.533  -33.172 16.110  1.00 40.59  ? 545 HOH A O    1 
HETATM 5796 O O    . HOH B 2 .   ? -2.185  -35.150 9.050   1.00 30.01  ? 546 HOH A O    1 
HETATM 5797 O O    . HOH B 2 .   ? 44.928  -20.779 4.830   1.00 41.59  ? 547 HOH A O    1 
HETATM 5798 O O    . HOH B 2 .   ? 17.969  -2.532  7.531   1.00 26.50  ? 548 HOH A O    1 
HETATM 5799 O O    . HOH B 2 .   ? 5.731   -6.255  -17.601 1.00 35.10  ? 549 HOH A O    1 
HETATM 5800 O O    . HOH B 2 .   ? 8.769   -17.961 9.286   1.00 15.97  ? 550 HOH A O    1 
HETATM 5801 O O    . HOH B 2 .   ? 45.005  -1.410  3.274   1.00 40.70  ? 551 HOH A O    1 
HETATM 5802 O O    . HOH B 2 .   ? 11.838  -32.623 15.872  1.00 39.58  ? 552 HOH A O    1 
HETATM 5803 O O    . HOH B 2 .   ? 40.386  -11.933 -12.816 1.00 38.31  ? 553 HOH A O    1 
HETATM 5804 O O    . HOH B 2 .   ? 24.907  -9.952  14.598  1.00 39.96  ? 554 HOH A O    1 
HETATM 5805 O O    . HOH B 2 .   ? 3.430   -13.601 -0.740  1.00 20.10  ? 555 HOH A O    1 
HETATM 5806 O O    . HOH B 2 .   ? -11.558 -29.851 8.868   1.00 40.93  ? 556 HOH A O    1 
HETATM 5807 O O    . HOH B 2 .   ? 6.866   -3.578  12.326  1.00 34.21  ? 557 HOH A O    1 
HETATM 5808 O O    . HOH B 2 .   ? 12.460  -6.217  -17.490 1.00 19.88  ? 558 HOH A O    1 
HETATM 5809 O O    . HOH B 2 .   ? 16.119  2.434   4.374   1.00 20.54  ? 559 HOH A O    1 
HETATM 5810 O O    . HOH B 2 .   ? 4.241   -20.303 -8.849  1.00 25.70  ? 560 HOH A O    1 
HETATM 5811 O O    . HOH B 2 .   ? 47.105  -17.791 -4.700  1.00 32.03  ? 561 HOH A O    1 
HETATM 5812 O O    . HOH B 2 .   ? 9.071   -7.676  -25.442 1.00 37.33  ? 562 HOH A O    1 
HETATM 5813 O O    . HOH B 2 .   ? 42.521  -9.309  5.246   1.00 30.79  ? 563 HOH A O    1 
HETATM 5814 O O    . HOH B 2 .   ? 27.856  -16.488 12.511  1.00 30.86  ? 564 HOH A O    1 
HETATM 5815 O O    . HOH B 2 .   ? 35.732  -14.215 4.935   1.00 18.44  ? 565 HOH A O    1 
HETATM 5816 O O    . HOH B 2 .   ? 10.024  -20.383 8.977   1.00 17.35  ? 566 HOH A O    1 
HETATM 5817 O O    . HOH B 2 .   ? 35.930  -2.466  -7.232  1.00 25.26  ? 567 HOH A O    1 
HETATM 5818 O O    . HOH B 2 .   ? -2.138  -37.020 0.547   1.00 32.89  ? 568 HOH A O    1 
HETATM 5819 O O    . HOH B 2 .   ? 5.001   -40.630 16.236  1.00 42.44  ? 569 HOH A O    1 
HETATM 5820 O O    . HOH B 2 .   ? 33.829  0.757   -8.764  1.00 36.20  ? 570 HOH A O    1 
HETATM 5821 O O    . HOH B 2 .   ? 11.232  -4.054  2.772   1.00 26.49  ? 571 HOH A O    1 
HETATM 5822 O O    . HOH B 2 .   ? 6.390   -27.586 12.594  1.00 24.57  ? 572 HOH A O    1 
HETATM 5823 O O    . HOH B 2 .   ? -7.554  -26.473 12.859  1.00 42.07  ? 573 HOH A O    1 
HETATM 5824 O O    . HOH B 2 .   ? 38.056  -9.883  13.227  1.00 41.00  ? 574 HOH A O    1 
HETATM 5825 O O    . HOH B 2 .   ? 7.433   -20.945 -11.455 1.00 27.15  ? 575 HOH A O    1 
HETATM 5826 O O    . HOH B 2 .   ? -3.433  -37.370 7.177   1.00 39.60  ? 576 HOH A O    1 
HETATM 5827 O O    . HOH B 2 .   ? 21.203  -25.046 13.445  1.00 43.86  ? 577 HOH A O    1 
HETATM 5828 O O    . HOH B 2 .   ? 49.226  -3.308  -4.967  1.00 44.89  ? 578 HOH A O    1 
HETATM 5829 O O    . HOH B 2 .   ? 32.470  3.306   5.015   1.00 36.03  ? 579 HOH A O    1 
HETATM 5830 O O    . HOH B 2 .   ? 22.047  -17.886 -4.807  1.00 27.26  ? 580 HOH A O    1 
HETATM 5831 O O    . HOH B 2 .   ? 6.954   -44.942 0.578   1.00 37.15  ? 581 HOH A O    1 
HETATM 5832 O O    . HOH B 2 .   ? 9.332   -21.473 -9.393  1.00 30.65  ? 582 HOH A O    1 
HETATM 5833 O O    . HOH B 2 .   ? 21.987  2.907   2.783   1.00 24.16  ? 583 HOH A O    1 
HETATM 5834 O O    . HOH B 2 .   ? 25.865  1.825   -10.068 1.00 33.17  ? 584 HOH A O    1 
HETATM 5835 O O    . HOH B 2 .   ? 13.440  -6.020  -21.577 1.00 35.11  ? 585 HOH A O    1 
HETATM 5836 O O    . HOH B 2 .   ? 33.916  -23.095 15.454  1.00 49.82  ? 586 HOH A O    1 
HETATM 5837 O O    . HOH B 2 .   ? 1.412   -9.998  -13.396 1.00 29.84  ? 587 HOH A O    1 
HETATM 5838 O O    . HOH B 2 .   ? 5.324   -8.334  -1.028  1.00 27.76  ? 588 HOH A O    1 
HETATM 5839 O O    . HOH B 2 .   ? 22.463  -24.338 -5.359  1.00 36.98  ? 589 HOH A O    1 
HETATM 5840 O O    . HOH B 2 .   ? 8.958   1.293   -11.028 1.00 31.13  ? 590 HOH A O    1 
HETATM 5841 O O    . HOH B 2 .   ? 15.746  -23.772 -7.757  1.00 22.69  ? 591 HOH A O    1 
HETATM 5842 O O    . HOH B 2 .   ? 0.081   -34.977 17.239  1.00 41.81  ? 592 HOH A O    1 
HETATM 5843 O O    . HOH B 2 .   ? 42.293  -3.986  8.766   1.00 32.85  ? 593 HOH A O    1 
HETATM 5844 O O    . HOH B 2 .   ? 19.199  -0.079  -14.612 1.00 23.86  ? 594 HOH A O    1 
HETATM 5845 O O    . HOH B 2 .   ? 3.317   -8.429  5.426   1.00 21.79  ? 595 HOH A O    1 
HETATM 5846 O O    . HOH B 2 .   ? 20.681  0.681   1.693   1.00 23.93  ? 596 HOH A O    1 
HETATM 5847 O O    . HOH B 2 .   ? 25.764  -15.822 -12.746 1.00 32.46  ? 597 HOH A O    1 
HETATM 5848 O O    . HOH B 2 .   ? 25.181  -12.266 17.422  1.00 36.16  ? 598 HOH A O    1 
HETATM 5849 O O    . HOH B 2 .   ? 18.715  -28.832 4.450   1.00 22.75  ? 599 HOH A O    1 
HETATM 5850 O O    . HOH B 2 .   ? -7.020  -27.259 -3.519  1.00 24.14  ? 600 HOH A O    1 
HETATM 5851 O O    . HOH B 2 .   ? 50.558  -6.224  -2.924  1.00 40.30  ? 601 HOH A O    1 
HETATM 5852 O O    . HOH B 2 .   ? 25.158  -19.365 2.402   1.00 23.36  ? 602 HOH A O    1 
HETATM 5853 O O    . HOH B 2 .   ? 5.560   -24.159 -18.006 1.00 41.56  ? 603 HOH A O    1 
HETATM 5854 O O    . HOH B 2 .   ? 2.366   -6.659  12.091  1.00 36.26  ? 604 HOH A O    1 
HETATM 5855 O O    . HOH B 2 .   ? 28.992  -10.938 16.328  1.00 27.59  ? 605 HOH A O    1 
HETATM 5856 O O    . HOH B 2 .   ? 45.219  -7.694  4.866   1.00 42.49  ? 606 HOH A O    1 
HETATM 5857 O O    . HOH B 2 .   ? 2.611   -18.740 -7.332  1.00 24.38  ? 607 HOH A O    1 
HETATM 5858 O O    . HOH B 2 .   ? 18.275  -7.420  -22.422 1.00 33.01  ? 608 HOH A O    1 
HETATM 5859 O O    . HOH B 2 .   ? 30.506  -10.210 -3.827  1.00 17.74  ? 609 HOH A O    1 
HETATM 5860 O O    . HOH B 2 .   ? 27.333  0.756   -12.955 1.00 35.80  ? 610 HOH A O    1 
HETATM 5861 O O    . HOH B 2 .   ? -0.670  -25.883 14.906  1.00 35.33  ? 611 HOH A O    1 
HETATM 5862 O O    . HOH B 2 .   ? 21.869  -16.222 -12.082 1.00 23.60  ? 612 HOH A O    1 
HETATM 5863 O O    . HOH B 2 .   ? -2.728  -25.301 -11.036 1.00 37.85  ? 613 HOH A O    1 
HETATM 5864 O O    . HOH B 2 .   ? 46.135  -6.141  -10.838 1.00 40.86  ? 614 HOH A O    1 
HETATM 5865 O O    . HOH B 2 .   ? 4.439   -33.288 -9.228  1.00 26.32  ? 615 HOH A O    1 
HETATM 5866 O O    . HOH B 2 .   ? 8.811   -13.703 18.650  1.00 28.29  ? 616 HOH A O    1 
HETATM 5867 O O    . HOH B 2 .   ? 42.947  -15.788 7.706   1.00 35.47  ? 617 HOH A O    1 
HETATM 5868 O O    . HOH B 2 .   ? 1.514   -39.028 14.852  1.00 37.67  ? 618 HOH A O    1 
HETATM 5869 O O    . HOH B 2 .   ? 20.113  -15.332 -23.771 1.00 29.93  ? 619 HOH A O    1 
HETATM 5870 O O    . HOH B 2 .   ? 44.334  -3.119  -15.749 1.00 45.15  ? 620 HOH A O    1 
HETATM 5871 O O    . HOH B 2 .   ? 22.408  4.051   -12.500 1.00 45.38  ? 621 HOH A O    1 
HETATM 5872 O O    . HOH B 2 .   ? 36.024  -11.944 15.347  1.00 30.95  ? 622 HOH A O    1 
HETATM 5873 O O    . HOH B 2 .   ? 40.708  -13.163 14.592  1.00 48.96  ? 623 HOH A O    1 
HETATM 5874 O O    . HOH B 2 .   ? 4.339   -22.121 -11.005 1.00 31.66  ? 624 HOH A O    1 
HETATM 5875 O O    . HOH B 2 .   ? 8.260   -1.426  3.538   1.00 41.50  ? 625 HOH A O    1 
HETATM 5876 O O    . HOH B 2 .   ? 16.326  -8.723  14.668  1.00 33.82  ? 626 HOH A O    1 
HETATM 5877 O O    . HOH B 2 .   ? 15.519  -35.727 -2.628  1.00 35.22  ? 627 HOH A O    1 
HETATM 5878 O O    . HOH B 2 .   ? 14.261  -38.142 -2.945  1.00 44.12  ? 628 HOH A O    1 
HETATM 5879 O O    . HOH B 2 .   ? 28.740  -4.853  14.002  1.00 29.70  ? 629 HOH A O    1 
HETATM 5880 O O    . HOH B 2 .   ? 0.057   -10.167 3.470   1.00 29.90  ? 630 HOH A O    1 
HETATM 5881 O O    . HOH B 2 .   ? 43.355  -13.571 6.509   1.00 32.80  ? 631 HOH A O    1 
HETATM 5882 O O    . HOH B 2 .   ? -1.219  -16.550 -2.930  1.00 42.71  ? 632 HOH A O    1 
HETATM 5883 O O    . HOH B 2 .   ? 10.613  -20.161 -7.351  1.00 19.66  ? 633 HOH A O    1 
HETATM 5884 O O    . HOH B 2 .   ? 16.258  -32.731 13.772  1.00 34.13  ? 634 HOH A O    1 
HETATM 5885 O O    . HOH B 2 .   ? 2.649   -12.576 19.952  1.00 42.66  ? 635 HOH A O    1 
HETATM 5886 O O    . HOH B 2 .   ? -1.685  -17.966 20.071  1.00 43.81  ? 636 HOH A O    1 
HETATM 5887 O O    . HOH B 2 .   ? 14.159  -21.719 -8.434  1.00 20.62  ? 637 HOH A O    1 
HETATM 5888 O O    . HOH B 2 .   ? 22.496  -13.632 -12.550 1.00 19.59  ? 638 HOH A O    1 
HETATM 5889 O O    . HOH B 2 .   ? 34.601  -2.898  11.320  1.00 32.20  ? 639 HOH A O    1 
HETATM 5890 O O    . HOH B 2 .   ? 6.771   -17.997 -19.004 1.00 39.98  ? 640 HOH A O    1 
HETATM 5891 O O    . HOH B 2 .   ? 27.036  -9.497  -7.696  1.00 18.10  ? 641 HOH A O    1 
HETATM 5892 O O    . HOH B 2 .   ? -2.020  -31.355 10.466  1.00 20.40  ? 642 HOH A O    1 
HETATM 5893 O O    . HOH B 2 .   ? 4.245   -36.306 15.613  1.00 34.64  ? 643 HOH A O    1 
HETATM 5894 O O    . HOH B 2 .   ? 38.038  -18.547 17.025  1.00 47.33  ? 644 HOH A O    1 
HETATM 5895 O O    . HOH B 2 .   ? 13.751  -35.823 -16.750 1.00 49.06  ? 645 HOH A O    1 
HETATM 5896 O O    . HOH B 2 .   ? 6.158   -12.979 15.939  1.00 23.96  ? 646 HOH A O    1 
HETATM 5897 O O    . HOH B 2 .   ? -0.283  -12.163 -7.484  1.00 38.40  ? 647 HOH A O    1 
HETATM 5898 O O    . HOH B 2 .   ? 27.102  -24.954 10.812  1.00 28.72  ? 648 HOH A O    1 
HETATM 5899 O O    . HOH B 2 .   ? 4.118   -28.414 11.018  1.00 19.79  ? 649 HOH A O    1 
HETATM 5900 O O    . HOH B 2 .   ? 12.806  -18.887 -8.640  1.00 15.41  ? 650 HOH A O    1 
HETATM 5901 O O    . HOH B 2 .   ? 24.776  -26.395 11.258  1.00 33.01  ? 651 HOH A O    1 
HETATM 5902 O O    . HOH B 2 .   ? 2.022   -15.542 0.180   1.00 26.15  ? 652 HOH A O    1 
HETATM 5903 O O    . HOH B 2 .   ? 10.889  -28.677 16.515  1.00 46.45  ? 653 HOH A O    1 
HETATM 5904 O O    . HOH B 2 .   ? -0.826  -28.394 15.962  1.00 34.71  ? 654 HOH A O    1 
HETATM 5905 O O    . HOH B 2 .   ? 34.909  -18.836 -9.943  1.00 41.55  ? 655 HOH A O    1 
HETATM 5906 O O    . HOH B 2 .   ? 19.604  -40.605 5.123   1.00 39.26  ? 656 HOH A O    1 
HETATM 5907 O O    . HOH B 2 .   ? -11.073 -27.376 -0.308  1.00 23.26  ? 657 HOH A O    1 
HETATM 5908 O O    . HOH B 2 .   ? 22.115  -22.168 -11.995 1.00 30.93  ? 658 HOH A O    1 
HETATM 5909 O O    . HOH B 2 .   ? 12.897  -1.163  10.103  1.00 30.35  ? 659 HOH A O    1 
HETATM 5910 O O    . HOH B 2 .   ? 21.583  -26.322 6.229   1.00 34.93  ? 660 HOH A O    1 
HETATM 5911 O O    . HOH B 2 .   ? 6.977   -33.529 -16.277 1.00 40.01  ? 661 HOH A O    1 
HETATM 5912 O O    . HOH B 2 .   ? 26.144  -28.446 4.699   1.00 43.69  ? 662 HOH A O    1 
HETATM 5913 O O    . HOH B 2 .   ? 4.786   -31.538 14.813  1.00 29.95  ? 663 HOH A O    1 
HETATM 5914 O O    . HOH B 2 .   ? 9.407   -44.986 8.059   1.00 41.39  ? 664 HOH A O    1 
HETATM 5915 O O    . HOH B 2 .   ? 8.116   -11.669 -25.105 1.00 22.00  ? 665 HOH A O    1 
HETATM 5916 O O    . HOH B 2 .   ? 44.794  -13.434 4.544   1.00 30.02  ? 666 HOH A O    1 
HETATM 5917 O O    . HOH B 2 .   ? 19.085  -26.374 3.115   1.00 25.80  ? 667 HOH A O    1 
HETATM 5918 O O    . HOH B 2 .   ? -4.249  -17.382 4.312   1.00 20.67  ? 668 HOH A O    1 
HETATM 5919 O O    . HOH B 2 .   ? 16.815  -42.186 2.724   1.00 40.21  ? 669 HOH A O    1 
HETATM 5920 O O    . HOH B 2 .   ? 25.839  -34.518 -0.250  1.00 41.23  ? 670 HOH A O    1 
HETATM 5921 O O    . HOH B 2 .   ? 4.795   -27.371 16.249  1.00 26.15  ? 671 HOH A O    1 
HETATM 5922 O O    . HOH B 2 .   ? 22.727  -4.090  13.808  1.00 35.78  ? 672 HOH A O    1 
HETATM 5923 O O    . HOH B 2 .   ? 32.047  -20.419 9.414   1.00 35.62  ? 673 HOH A O    1 
HETATM 5924 O O    . HOH B 2 .   ? 10.304  3.065   9.517   1.00 42.98  ? 674 HOH A O    1 
HETATM 5925 O O    . HOH B 2 .   ? 15.449  -41.422 -0.599  1.00 45.33  ? 675 HOH A O    1 
HETATM 5926 O O    . HOH B 2 .   ? 3.269   -16.527 -3.551  1.00 27.32  ? 676 HOH A O    1 
HETATM 5927 O O    . HOH B 2 .   ? 28.212  -10.841 -5.234  1.00 15.64  ? 677 HOH A O    1 
HETATM 5928 O O    . HOH B 2 .   ? 34.001  -21.388 -9.841  1.00 41.68  ? 678 HOH A O    1 
HETATM 5929 O O    . HOH B 2 .   ? 2.338   -23.045 10.780  1.00 18.57  ? 679 HOH A O    1 
HETATM 5930 O O    . HOH B 2 .   ? 29.486  -22.559 -1.199  1.00 40.36  ? 680 HOH A O    1 
HETATM 5931 O O    . HOH B 2 .   ? 14.489  -43.091 13.741  1.00 39.94  ? 681 HOH A O    1 
HETATM 5932 O O    . HOH B 2 .   ? 16.652  -12.318 16.472  1.00 29.46  ? 682 HOH A O    1 
HETATM 5933 O O    . HOH B 2 .   ? -2.988  -37.593 2.610   1.00 39.36  ? 683 HOH A O    1 
HETATM 5934 O O    . HOH B 2 .   ? -0.053  -25.266 12.127  1.00 23.94  ? 684 HOH A O    1 
HETATM 5935 O O    . HOH B 2 .   ? -0.997  -5.319  -9.645  1.00 42.61  ? 685 HOH A O    1 
HETATM 5936 O O    . HOH B 2 .   ? -2.866  -38.066 12.955  1.00 28.98  ? 686 HOH A O    1 
HETATM 5937 O O    . HOH B 2 .   ? 23.131  -16.219 -16.721 1.00 33.66  ? 687 HOH A O    1 
HETATM 5938 O O    . HOH B 2 .   ? 6.061   -3.823  3.337   1.00 35.16  ? 688 HOH A O    1 
HETATM 5939 O O    . HOH B 2 .   ? 25.757  -18.683 -5.681  1.00 38.29  ? 689 HOH A O    1 
HETATM 5940 O O    . HOH B 2 .   ? 33.321  -21.576 11.527  1.00 32.99  ? 690 HOH A O    1 
HETATM 5941 O O    . HOH B 2 .   ? 40.096  -26.927 7.986   1.00 48.06  ? 691 HOH A O    1 
HETATM 5942 O O    . HOH B 2 .   ? 17.577  -39.903 3.490   1.00 31.59  ? 692 HOH A O    1 
HETATM 5943 O O    . HOH B 2 .   ? 38.204  -7.848  14.174  1.00 38.26  ? 693 HOH A O    1 
HETATM 5944 O O    . HOH B 2 .   ? 6.530   -17.399 18.586  1.00 36.46  ? 694 HOH A O    1 
HETATM 5945 O O    . HOH B 2 .   ? -3.700  -19.465 -8.336  1.00 43.76  ? 695 HOH A O    1 
HETATM 5946 O O    . HOH B 2 .   ? 0.126   -15.490 -6.444  1.00 42.78  ? 696 HOH A O    1 
HETATM 5947 O O    . HOH B 2 .   ? 43.332  -20.259 -3.630  1.00 30.00  ? 697 HOH A O    1 
HETATM 5948 O O    . HOH B 2 .   ? 23.847  -19.866 -3.764  1.00 39.75  ? 698 HOH A O    1 
HETATM 5949 O O    . HOH B 2 .   ? 26.149  -16.827 19.633  1.00 44.48  ? 699 HOH A O    1 
HETATM 5950 O O    . HOH B 2 .   ? 28.238  -17.788 -5.555  1.00 29.28  ? 700 HOH A O    1 
HETATM 5951 O O    . HOH B 2 .   ? 21.737  -2.841  -24.040 1.00 40.47  ? 701 HOH A O    1 
HETATM 5952 O O    . HOH B 2 .   ? 32.156  0.934   0.665   1.00 27.37  ? 702 HOH A O    1 
HETATM 5953 O O    . HOH B 2 .   ? 1.062   -16.026 20.694  1.00 42.37  ? 703 HOH A O    1 
HETATM 5954 O O    . HOH B 2 .   ? 35.101  1.124   -3.380  1.00 33.36  ? 704 HOH A O    1 
HETATM 5955 O O    . HOH B 2 .   ? 17.422  -9.734  17.127  1.00 31.89  ? 705 HOH A O    1 
HETATM 5956 O O    . HOH B 2 .   ? 14.339  -41.229 -2.924  1.00 48.89  ? 706 HOH A O    1 
HETATM 5957 O O    . HOH B 2 .   ? 1.763   -36.705 16.132  1.00 39.90  ? 707 HOH A O    1 
HETATM 5958 O O    . HOH B 2 .   ? 41.463  -9.705  -15.301 1.00 36.56  ? 708 HOH A O    1 
HETATM 5959 O O    . HOH B 2 .   ? -5.193  -34.305 -5.620  1.00 37.80  ? 709 HOH A O    1 
HETATM 5960 O O    . HOH B 2 .   ? 14.679  -3.061  10.328  1.00 37.50  ? 710 HOH A O    1 
HETATM 5961 O O    . HOH B 2 .   ? -1.408  -30.795 -9.914  1.00 43.62  ? 711 HOH A O    1 
HETATM 5962 O O    . HOH B 2 .   ? 27.154  -20.793 3.956   1.00 20.78  ? 712 HOH A O    1 
HETATM 5963 O O    . HOH B 2 .   ? -1.511  -23.491 14.874  1.00 37.77  ? 713 HOH A O    1 
HETATM 5964 O O    . HOH B 2 .   ? 34.847  -5.058  15.628  1.00 37.71  ? 714 HOH A O    1 
HETATM 5965 O O    . HOH B 2 .   ? 43.184  -23.893 8.282   1.00 40.32  ? 715 HOH A O    1 
HETATM 5966 O O    . HOH B 2 .   ? 14.491  -38.573 14.506  1.00 44.09  ? 716 HOH A O    1 
HETATM 5967 O O    . HOH B 2 .   ? -1.045  -22.918 12.252  1.00 35.62  ? 717 HOH A O    1 
HETATM 5968 O O    . HOH B 2 .   ? 5.976   -5.727  14.297  1.00 33.34  ? 718 HOH A O    1 
HETATM 5969 O O    . HOH B 2 .   ? 50.066  -10.372 -4.055  1.00 42.61  ? 719 HOH A O    1 
HETATM 5970 O O    . HOH B 2 .   ? 2.873   -28.577 17.447  1.00 44.30  ? 720 HOH A O    1 
HETATM 5971 O O    . HOH B 2 .   ? -13.348 -27.892 -1.171  1.00 33.38  ? 721 HOH A O    1 
HETATM 5972 O O    . HOH B 2 .   ? 44.146  -20.160 0.917   1.00 29.17  ? 722 HOH A O    1 
HETATM 5973 O O    . HOH B 2 .   ? 7.297   -0.699  6.033   1.00 34.72  ? 723 HOH A O    1 
HETATM 5974 O O    . HOH B 2 .   ? 40.513  -8.001  -15.961 1.00 40.84  ? 724 HOH A O    1 
HETATM 5975 O O    . HOH B 2 .   ? 5.742   -45.452 2.371   1.00 46.11  ? 725 HOH A O    1 
HETATM 5976 O O    . HOH B 2 .   ? 40.649  -21.052 -14.126 1.00 45.85  ? 726 HOH A O    1 
HETATM 5977 O O    . HOH B 2 .   ? 27.368  -9.202  15.884  1.00 33.20  ? 727 HOH A O    1 
HETATM 5978 O O    . HOH B 2 .   ? 7.949   -25.509 20.408  1.00 42.41  ? 728 HOH A O    1 
HETATM 5979 O O    . HOH B 2 .   ? 15.990  -16.628 -23.791 1.00 43.54  ? 729 HOH A O    1 
HETATM 5980 O O    . HOH B 2 .   ? 6.594   -15.331 -19.633 1.00 40.44  ? 730 HOH A O    1 
HETATM 5981 O O    . HOH B 2 .   ? 3.632   -35.562 -9.929  1.00 37.54  ? 731 HOH A O    1 
HETATM 5982 O O    . HOH B 2 .   ? 43.938  -18.886 3.455   1.00 31.97  ? 732 HOH A O    1 
HETATM 5983 O O    . HOH B 2 .   ? 12.396  0.498   -8.445  1.00 29.18  ? 733 HOH A O    1 
HETATM 5984 O O    . HOH B 2 .   ? 9.604   -9.956  -26.787 1.00 39.72  ? 734 HOH A O    1 
HETATM 5985 O O    . HOH B 2 .   ? 17.668  -14.933 -24.911 1.00 32.93  ? 735 HOH A O    1 
HETATM 5986 O O    . HOH B 2 .   ? 10.329  -38.351 -17.496 1.00 53.85  ? 736 HOH A O    1 
HETATM 5987 O O    . HOH B 2 .   ? 48.343  -11.830 -6.092  1.00 39.80  ? 737 HOH A O    1 
HETATM 5988 O O    . HOH B 2 .   ? 24.036  -17.281 -10.858 1.00 36.30  ? 738 HOH A O    1 
HETATM 5989 O O    . HOH B 2 .   ? 48.939  -11.013 -2.085  1.00 45.36  ? 739 HOH A O    1 
HETATM 5990 O O    . HOH B 2 .   ? 45.989  -8.808  3.071   1.00 44.94  ? 740 HOH A O    1 
HETATM 5991 O O    . HOH B 2 .   ? -6.653  -32.515 -7.369  1.00 47.82  ? 741 HOH A O    1 
HETATM 5992 O O    . HOH B 2 .   ? 4.646   -33.387 -14.473 1.00 39.34  ? 742 HOH A O    1 
HETATM 5993 O O    . HOH B 2 .   ? 26.737  -20.434 -3.142  1.00 40.53  ? 743 HOH A O    1 
HETATM 5994 O O    . HOH B 2 .   ? 27.593  -33.910 1.040   1.00 41.76  ? 744 HOH A O    1 
HETATM 5995 O O    . HOH B 2 .   ? 34.283  -4.206  -14.798 1.00 43.90  ? 745 HOH A O    1 
HETATM 5996 O O    . HOH B 2 .   ? 37.486  -0.447  10.157  1.00 30.83  ? 746 HOH A O    1 
HETATM 5997 O O    . HOH B 2 .   ? 20.226  -28.612 6.542   1.00 28.21  ? 747 HOH A O    1 
HETATM 5998 O O    . HOH B 2 .   ? 22.699  2.140   -10.013 1.00 38.95  ? 748 HOH A O    1 
HETATM 5999 O O    . HOH B 2 .   ? 41.645  -23.357 18.183  1.00 56.63  ? 749 HOH A O    1 
HETATM 6000 O O    . HOH B 2 .   ? 3.396   -31.226 -13.629 1.00 37.44  ? 750 HOH A O    1 
HETATM 6001 O O    . HOH B 2 .   ? 42.825  -7.690  8.982   1.00 36.74  ? 751 HOH A O    1 
HETATM 6002 O O    . HOH B 2 .   ? 12.547  -20.659 -18.951 1.00 33.25  ? 752 HOH A O    1 
HETATM 6003 O O    . HOH B 2 .   ? 10.162  -20.802 -20.133 1.00 42.30  ? 753 HOH A O    1 
HETATM 6004 O O    . HOH B 2 .   ? 12.249  2.267   2.608   1.00 32.27  ? 754 HOH A O    1 
HETATM 6005 O O    . HOH B 2 .   ? 27.677  7.603   -5.894  1.00 31.78  ? 755 HOH A O    1 
HETATM 6006 O O    . HOH B 2 .   ? -0.229  -7.892  -4.311  1.00 42.59  ? 756 HOH A O    1 
HETATM 6007 O O    . HOH B 2 .   ? 0.433   -9.488  -10.910 1.00 34.86  ? 757 HOH A O    1 
HETATM 6008 O O    . HOH B 2 .   ? 19.475  -8.296  16.930  1.00 34.44  ? 758 HOH A O    1 
HETATM 6009 O O    . HOH B 2 .   ? 14.115  0.872   -15.610 1.00 39.31  ? 759 HOH A O    1 
HETATM 6010 O O    . HOH B 2 .   ? 14.315  -18.568 -20.175 1.00 38.43  ? 760 HOH A O    1 
HETATM 6011 O O    . HOH B 2 .   ? 24.623  -23.905 -7.696  1.00 39.71  ? 761 HOH A O    1 
HETATM 6012 O O    . HOH B 2 .   ? 17.022  1.110   -14.301 1.00 32.67  ? 762 HOH A O    1 
HETATM 6013 O O    . HOH B 2 .   ? -1.882  -33.087 -8.441  1.00 46.18  ? 763 HOH A O    1 
HETATM 6014 O O    . HOH B 2 .   ? 23.602  -16.749 -14.400 1.00 43.67  ? 764 HOH A O    1 
HETATM 6015 O O    . HOH B 2 .   ? 6.151   -0.893  13.304  1.00 41.26  ? 765 HOH A O    1 
HETATM 6016 O O    . HOH B 2 .   ? 27.213  -15.106 21.280  1.00 42.55  ? 766 HOH A O    1 
HETATM 6017 O O    . HOH B 2 .   ? 11.990  -3.905  -20.747 1.00 37.23  ? 767 HOH A O    1 
HETATM 6018 O O    . HOH B 2 .   ? 6.757   -14.758 19.626  1.00 43.52  ? 768 HOH A O    1 
HETATM 6019 O O    . HOH B 2 .   ? 22.074  -23.284 -14.676 1.00 43.12  ? 769 HOH A O    1 
HETATM 6020 O O    . HOH B 2 .   ? 33.210  2.123   2.812   1.00 31.44  ? 770 HOH A O    1 
HETATM 6021 O O    . HOH B 2 .   ? -7.764  -35.759 2.497   1.00 32.33  ? 771 HOH A O    1 
HETATM 6022 O O    . HOH B 2 .   ? 11.074  -1.662  -17.574 1.00 31.74  ? 772 HOH A O    1 
HETATM 6023 O O    . HOH B 2 .   ? 39.718  -0.697  11.092  1.00 38.33  ? 773 HOH A O    1 
HETATM 6024 O O    . HOH B 2 .   ? 6.346   -29.201 14.806  1.00 31.75  ? 774 HOH A O    1 
HETATM 6025 O O    . HOH B 2 .   ? 10.412  -4.951  -18.310 1.00 29.83  ? 775 HOH A O    1 
HETATM 6026 O O    . HOH B 2 .   ? 15.135  -26.335 16.973  1.00 36.64  ? 776 HOH A O    1 
HETATM 6027 O O    . HOH B 2 .   ? 31.956  -2.383  -13.951 1.00 44.22  ? 777 HOH A O    1 
HETATM 6028 O O    . HOH B 2 .   ? 8.592   -29.617 16.066  1.00 38.81  ? 778 HOH A O    1 
HETATM 6029 O O    . HOH B 2 .   ? 47.661  -6.123  0.973   1.00 48.81  ? 779 HOH A O    1 
HETATM 6030 O O    . HOH B 2 .   ? 22.833  -27.033 9.951   1.00 44.76  ? 780 HOH A O    1 
HETATM 6031 O O    . HOH B 2 .   ? 9.013   -18.626 -20.954 1.00 35.14  ? 781 HOH A O    1 
HETATM 6032 O O    . HOH B 2 .   ? 15.793  -19.177 17.852  1.00 44.27  ? 782 HOH A O    1 
HETATM 6033 O O    . HOH B 2 .   ? 0.845   -16.459 -18.250 1.00 44.74  ? 783 HOH A O    1 
HETATM 6034 O O    . HOH B 2 .   ? 49.275  -3.955  -2.772  1.00 40.62  ? 784 HOH A O    1 
HETATM 6035 O O    . HOH B 2 .   ? 0.561   -15.430 -4.083  1.00 44.57  ? 785 HOH A O    1 
HETATM 6036 O O    . HOH B 2 .   ? 34.592  -17.640 -11.923 1.00 43.66  ? 786 HOH A O    1 
HETATM 6037 O O    . HOH B 2 .   ? -1.106  -12.383 -5.035  1.00 42.42  ? 787 HOH A O    1 
HETATM 6038 O O    . HOH B 2 .   ? 48.262  -17.237 -7.318  1.00 41.99  ? 788 HOH A O    1 
HETATM 6039 O O    . HOH B 2 .   ? 50.865  -15.625 3.260   1.00 45.08  ? 789 HOH A O    1 
HETATM 6040 O O    . HOH B 2 .   ? 15.731  -6.457  -22.810 1.00 44.41  ? 790 HOH A O    1 
HETATM 6041 O O    . HOH B 2 .   ? 47.464  -9.174  -0.393  1.00 38.78  ? 791 HOH A O    1 
HETATM 6042 O O    . HOH B 2 .   ? 12.490  -34.971 16.870  1.00 43.75  ? 792 HOH A O    1 
HETATM 6043 O O    . HOH B 2 .   ? 4.551   -38.927 -8.522  1.00 43.27  ? 793 HOH A O    1 
HETATM 6044 O O    . HOH B 2 .   ? 38.912  -11.701 14.861  1.00 42.99  ? 794 HOH A O    1 
HETATM 6045 O O    . HOH B 2 .   ? -2.906  -34.880 17.490  1.00 43.03  ? 795 HOH A O    1 
HETATM 6046 O O    . HOH B 2 .   ? -5.842  -21.061 11.444  1.00 47.52  ? 796 HOH A O    1 
HETATM 6047 O O    . HOH B 2 .   ? 35.696  1.761   3.554   1.00 35.20  ? 797 HOH A O    1 
HETATM 6048 O O    . HOH B 2 .   ? 10.074  1.824   -4.934  1.00 37.65  ? 798 HOH A O    1 
HETATM 6049 O O    . HOH B 2 .   ? -3.074  -7.529  13.703  1.00 48.68  ? 799 HOH A O    1 
HETATM 6050 O O    . HOH B 2 .   ? 10.004  -29.506 -21.644 1.00 54.11  ? 800 HOH A O    1 
HETATM 6051 O O    . HOH B 2 .   ? 10.310  1.717   -9.187  1.00 35.87  ? 801 HOH A O    1 
HETATM 6052 O O    . HOH B 2 .   ? -0.901  -39.544 12.473  1.00 30.58  ? 802 HOH A O    1 
HETATM 6053 O O    . HOH B 2 .   ? 2.028   -5.959  8.822   1.00 39.65  ? 803 HOH A O    1 
HETATM 6054 O O    . HOH B 2 .   ? 33.515  -24.091 11.208  1.00 40.91  ? 804 HOH A O    1 
HETATM 6055 O O    . HOH B 2 .   ? 23.238  -17.659 -22.284 1.00 41.00  ? 805 HOH A O    1 
HETATM 6056 O O    . HOH B 2 .   ? 37.588  1.953   -6.343  1.00 41.31  ? 806 HOH A O    1 
HETATM 6057 O O    . HOH B 2 .   ? 10.402  -46.786 9.836   1.00 45.54  ? 807 HOH A O    1 
HETATM 6058 O O    . HOH B 2 .   ? 0.971   -7.718  4.281   1.00 34.20  ? 808 HOH A O    1 
HETATM 6059 O O    . HOH B 2 .   ? 3.877   -16.023 -20.109 1.00 42.49  ? 809 HOH A O    1 
HETATM 6060 O O    . HOH B 2 .   ? 14.833  2.912   -10.661 1.00 42.68  ? 810 HOH A O    1 
HETATM 6061 O O    . HOH B 2 .   ? 36.456  0.111   -7.669  1.00 30.50  ? 811 HOH A O    1 
HETATM 6062 O O    . HOH B 2 .   ? -2.145  -14.338 -3.316  1.00 51.80  ? 812 HOH A O    1 
HETATM 6063 O O    . HOH B 2 .   ? 47.488  -6.320  3.476   1.00 50.81  ? 813 HOH A O    1 
HETATM 6064 O O    . HOH B 2 .   ? 2.772   -29.720 -15.860 1.00 42.51  ? 814 HOH A O    1 
HETATM 6065 O O    . HOH B 2 .   ? 28.253  -16.417 -13.011 1.00 42.48  ? 815 HOH A O    1 
HETATM 6066 O O    . HOH B 2 .   ? 24.620  -8.271  16.345  1.00 40.59  ? 816 HOH A O    1 
HETATM 6067 O O    . HOH B 2 .   ? 10.422  -26.415 20.053  1.00 45.93  ? 817 HOH A O    1 
HETATM 6068 O O    . HOH B 2 .   ? 27.787  -6.229  -25.803 1.00 35.44  ? 818 HOH A O    1 
HETATM 6069 O O    . HOH B 2 .   ? 16.920  -37.120 12.770  1.00 41.03  ? 819 HOH A O    1 
HETATM 6070 O O    . HOH B 2 .   ? 17.393  -39.825 12.963  1.00 50.59  ? 820 HOH A O    1 
HETATM 6071 O O    . HOH B 2 .   ? 31.264  -3.945  14.352  1.00 31.84  ? 821 HOH A O    1 
HETATM 6072 O O    . HOH B 2 .   ? 2.997   -19.789 22.657  1.00 39.45  ? 822 HOH A O    1 
HETATM 6073 O O    . HOH B 2 .   ? 23.964  -20.107 -11.883 1.00 43.10  ? 823 HOH A O    1 
HETATM 6074 O O    . HOH B 2 .   ? 8.177   -5.466  -25.569 1.00 40.71  ? 824 HOH A O    1 
HETATM 6075 O O    . HOH B 2 .   ? 4.372   -27.065 21.125  1.00 46.87  ? 825 HOH A O    1 
HETATM 6076 O O    . HOH B 2 .   ? 12.212  -0.025  -19.906 1.00 41.56  ? 826 HOH A O    1 
HETATM 6077 O O    . HOH B 2 .   ? 8.745   -1.064  -16.857 1.00 38.41  ? 827 HOH A O    1 
HETATM 6078 O O    . HOH B 2 .   ? -3.929  -16.731 18.972  1.00 50.79  ? 828 HOH A O    1 
HETATM 6079 O O    . HOH B 2 .   ? 14.618  -22.838 20.258  1.00 42.47  ? 829 HOH A O    1 
HETATM 6080 O O    . HOH B 2 .   ? 11.485  -35.364 -22.355 1.00 43.58  ? 830 HOH A O    1 
HETATM 6081 O O    . HOH B 2 .   ? 1.838   -17.719 22.473  1.00 39.91  ? 831 HOH A O    1 
HETATM 6082 O O    . HOH B 2 .   ? 6.184   -27.326 18.802  1.00 39.62  ? 832 HOH A O    1 
HETATM 6083 O O    . HOH B 2 .   ? 21.053  1.237   -16.578 1.00 40.13  ? 833 HOH A O    1 
HETATM 6084 O O    . HOH B 2 .   ? 29.157  -17.478 -11.004 1.00 40.49  ? 834 HOH A O    1 
HETATM 6085 O O    . HOH B 2 .   ? 33.876  -14.681 -12.460 1.00 40.67  ? 835 HOH A O    1 
HETATM 6086 O O    . HOH B 2 .   ? -5.651  -10.726 19.893  1.00 47.00  ? 836 HOH A O    1 
HETATM 6087 O O    . HOH B 2 .   ? 31.037  -10.857 -16.431 1.00 43.57  ? 837 HOH A O    1 
HETATM 6088 O O    . HOH B 2 .   ? 8.635   -31.499 -23.172 1.00 55.62  ? 838 HOH A O    1 
HETATM 6089 O O    . HOH B 2 .   ? 31.859  -1.718  14.238  1.00 43.21  ? 839 HOH A O    1 
HETATM 6090 O O    . HOH B 2 .   ? -2.670  -28.209 -15.057 1.00 45.91  ? 840 HOH A O    1 
# 
