data_9JOM
# 
_entry.id   9JOM 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.398 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9JOM         pdb_00009jom 10.2210/pdb9jom/pdb 
WWPDB D_1300051839 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-11-27 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9JOM 
_pdbx_database_status.recvd_initial_deposition_date   2024-09-25 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              changyg@ouc.edu.cn 
_pdbx_contact_author.name_first         Yaoguang 
_pdbx_contact_author.name_last          Chang 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-8234-7272 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Chen, G.N.'  1 ? 
'Chang, Y.G.' 2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Structure of endo-1.3-fucanase (Fun168E) at 2.04 Angstroms resulution.' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Chen, G.N.'  1 ? 
primary 'Chang, Y.G.' 2 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'Glycoside-hydrolase family GH114 TIM-barrel domain-containing protein' 45569.551 1   ? ? ? ? 
2 water   nat water                                                                   18.015    391 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MGSSHHHHHHSSGLVPRGSHMASMTGGQQMGRGSQSKTNKDYYPEFSWKTVPVAFHFAKRNGLMTDKELDFVTSHSNFIV
LEKGHGGDIRTEKGIDNEAQRIKDINPKAKVVFYWNAFLDYNLYDAHKEYENHKEWWLKKLDGNYDYKSAKVKRYDLSNP
AFRKWWVSIAKKAVVDGHADGVFMDAFIQVINKGNIELWGQKKYDAIQQGLKDLIAETRAAIGEDHLIVYNGIRSIPNRN
VGNDFPEHTDAVMIEHFANFQSKSKESMLQDILEMEKAGKTGKIVVFKAWPNEHSWIDKNFMAKPLQEKRKIARANITFP
LAAFLAGAQENSYFIYNWGYRMDDGGLEWYPELDKSLGKPLNEMKVHNWELTRNYEHASVWLNLATKEAKINWK
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MGSSHHHHHHSSGLVPRGSHMASMTGGQQMGRGSQSKTNKDYYPEFSWKTVPVAFHFAKRNGLMTDKELDFVTSHSNFIV
LEKGHGGDIRTEKGIDNEAQRIKDINPKAKVVFYWNAFLDYNLYDAHKEYENHKEWWLKKLDGNYDYKSAKVKRYDLSNP
AFRKWWVSIAKKAVVDGHADGVFMDAFIQVINKGNIELWGQKKYDAIQQGLKDLIAETRAAIGEDHLIVYNGIRSIPNRN
VGNDFPEHTDAVMIEHFANFQSKSKESMLQDILEMEKAGKTGKIVVFKAWPNEHSWIDKNFMAKPLQEKRKIARANITFP
LAAFLAGAQENSYFIYNWGYRMDDGGLEWYPELDKSLGKPLNEMKVHNWELTRNYEHASVWLNLATKEAKINWK
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLY n 
1 3   SER n 
1 4   SER n 
1 5   HIS n 
1 6   HIS n 
1 7   HIS n 
1 8   HIS n 
1 9   HIS n 
1 10  HIS n 
1 11  SER n 
1 12  SER n 
1 13  GLY n 
1 14  LEU n 
1 15  VAL n 
1 16  PRO n 
1 17  ARG n 
1 18  GLY n 
1 19  SER n 
1 20  HIS n 
1 21  MET n 
1 22  ALA n 
1 23  SER n 
1 24  MET n 
1 25  THR n 
1 26  GLY n 
1 27  GLY n 
1 28  GLN n 
1 29  GLN n 
1 30  MET n 
1 31  GLY n 
1 32  ARG n 
1 33  GLY n 
1 34  SER n 
1 35  GLN n 
1 36  SER n 
1 37  LYS n 
1 38  THR n 
1 39  ASN n 
1 40  LYS n 
1 41  ASP n 
1 42  TYR n 
1 43  TYR n 
1 44  PRO n 
1 45  GLU n 
1 46  PHE n 
1 47  SER n 
1 48  TRP n 
1 49  LYS n 
1 50  THR n 
1 51  VAL n 
1 52  PRO n 
1 53  VAL n 
1 54  ALA n 
1 55  PHE n 
1 56  HIS n 
1 57  PHE n 
1 58  ALA n 
1 59  LYS n 
1 60  ARG n 
1 61  ASN n 
1 62  GLY n 
1 63  LEU n 
1 64  MET n 
1 65  THR n 
1 66  ASP n 
1 67  LYS n 
1 68  GLU n 
1 69  LEU n 
1 70  ASP n 
1 71  PHE n 
1 72  VAL n 
1 73  THR n 
1 74  SER n 
1 75  HIS n 
1 76  SER n 
1 77  ASN n 
1 78  PHE n 
1 79  ILE n 
1 80  VAL n 
1 81  LEU n 
1 82  GLU n 
1 83  LYS n 
1 84  GLY n 
1 85  HIS n 
1 86  GLY n 
1 87  GLY n 
1 88  ASP n 
1 89  ILE n 
1 90  ARG n 
1 91  THR n 
1 92  GLU n 
1 93  LYS n 
1 94  GLY n 
1 95  ILE n 
1 96  ASP n 
1 97  ASN n 
1 98  GLU n 
1 99  ALA n 
1 100 GLN n 
1 101 ARG n 
1 102 ILE n 
1 103 LYS n 
1 104 ASP n 
1 105 ILE n 
1 106 ASN n 
1 107 PRO n 
1 108 LYS n 
1 109 ALA n 
1 110 LYS n 
1 111 VAL n 
1 112 VAL n 
1 113 PHE n 
1 114 TYR n 
1 115 TRP n 
1 116 ASN n 
1 117 ALA n 
1 118 PHE n 
1 119 LEU n 
1 120 ASP n 
1 121 TYR n 
1 122 ASN n 
1 123 LEU n 
1 124 TYR n 
1 125 ASP n 
1 126 ALA n 
1 127 HIS n 
1 128 LYS n 
1 129 GLU n 
1 130 TYR n 
1 131 GLU n 
1 132 ASN n 
1 133 HIS n 
1 134 LYS n 
1 135 GLU n 
1 136 TRP n 
1 137 TRP n 
1 138 LEU n 
1 139 LYS n 
1 140 LYS n 
1 141 LEU n 
1 142 ASP n 
1 143 GLY n 
1 144 ASN n 
1 145 TYR n 
1 146 ASP n 
1 147 TYR n 
1 148 LYS n 
1 149 SER n 
1 150 ALA n 
1 151 LYS n 
1 152 VAL n 
1 153 LYS n 
1 154 ARG n 
1 155 TYR n 
1 156 ASP n 
1 157 LEU n 
1 158 SER n 
1 159 ASN n 
1 160 PRO n 
1 161 ALA n 
1 162 PHE n 
1 163 ARG n 
1 164 LYS n 
1 165 TRP n 
1 166 TRP n 
1 167 VAL n 
1 168 SER n 
1 169 ILE n 
1 170 ALA n 
1 171 LYS n 
1 172 LYS n 
1 173 ALA n 
1 174 VAL n 
1 175 VAL n 
1 176 ASP n 
1 177 GLY n 
1 178 HIS n 
1 179 ALA n 
1 180 ASP n 
1 181 GLY n 
1 182 VAL n 
1 183 PHE n 
1 184 MET n 
1 185 ASP n 
1 186 ALA n 
1 187 PHE n 
1 188 ILE n 
1 189 GLN n 
1 190 VAL n 
1 191 ILE n 
1 192 ASN n 
1 193 LYS n 
1 194 GLY n 
1 195 ASN n 
1 196 ILE n 
1 197 GLU n 
1 198 LEU n 
1 199 TRP n 
1 200 GLY n 
1 201 GLN n 
1 202 LYS n 
1 203 LYS n 
1 204 TYR n 
1 205 ASP n 
1 206 ALA n 
1 207 ILE n 
1 208 GLN n 
1 209 GLN n 
1 210 GLY n 
1 211 LEU n 
1 212 LYS n 
1 213 ASP n 
1 214 LEU n 
1 215 ILE n 
1 216 ALA n 
1 217 GLU n 
1 218 THR n 
1 219 ARG n 
1 220 ALA n 
1 221 ALA n 
1 222 ILE n 
1 223 GLY n 
1 224 GLU n 
1 225 ASP n 
1 226 HIS n 
1 227 LEU n 
1 228 ILE n 
1 229 VAL n 
1 230 TYR n 
1 231 ASN n 
1 232 GLY n 
1 233 ILE n 
1 234 ARG n 
1 235 SER n 
1 236 ILE n 
1 237 PRO n 
1 238 ASN n 
1 239 ARG n 
1 240 ASN n 
1 241 VAL n 
1 242 GLY n 
1 243 ASN n 
1 244 ASP n 
1 245 PHE n 
1 246 PRO n 
1 247 GLU n 
1 248 HIS n 
1 249 THR n 
1 250 ASP n 
1 251 ALA n 
1 252 VAL n 
1 253 MET n 
1 254 ILE n 
1 255 GLU n 
1 256 HIS n 
1 257 PHE n 
1 258 ALA n 
1 259 ASN n 
1 260 PHE n 
1 261 GLN n 
1 262 SER n 
1 263 LYS n 
1 264 SER n 
1 265 LYS n 
1 266 GLU n 
1 267 SER n 
1 268 MET n 
1 269 LEU n 
1 270 GLN n 
1 271 ASP n 
1 272 ILE n 
1 273 LEU n 
1 274 GLU n 
1 275 MET n 
1 276 GLU n 
1 277 LYS n 
1 278 ALA n 
1 279 GLY n 
1 280 LYS n 
1 281 THR n 
1 282 GLY n 
1 283 LYS n 
1 284 ILE n 
1 285 VAL n 
1 286 VAL n 
1 287 PHE n 
1 288 LYS n 
1 289 ALA n 
1 290 TRP n 
1 291 PRO n 
1 292 ASN n 
1 293 GLU n 
1 294 HIS n 
1 295 SER n 
1 296 TRP n 
1 297 ILE n 
1 298 ASP n 
1 299 LYS n 
1 300 ASN n 
1 301 PHE n 
1 302 MET n 
1 303 ALA n 
1 304 LYS n 
1 305 PRO n 
1 306 LEU n 
1 307 GLN n 
1 308 GLU n 
1 309 LYS n 
1 310 ARG n 
1 311 LYS n 
1 312 ILE n 
1 313 ALA n 
1 314 ARG n 
1 315 ALA n 
1 316 ASN n 
1 317 ILE n 
1 318 THR n 
1 319 PHE n 
1 320 PRO n 
1 321 LEU n 
1 322 ALA n 
1 323 ALA n 
1 324 PHE n 
1 325 LEU n 
1 326 ALA n 
1 327 GLY n 
1 328 ALA n 
1 329 GLN n 
1 330 GLU n 
1 331 ASN n 
1 332 SER n 
1 333 TYR n 
1 334 PHE n 
1 335 ILE n 
1 336 TYR n 
1 337 ASN n 
1 338 TRP n 
1 339 GLY n 
1 340 TYR n 
1 341 ARG n 
1 342 MET n 
1 343 ASP n 
1 344 ASP n 
1 345 GLY n 
1 346 GLY n 
1 347 LEU n 
1 348 GLU n 
1 349 TRP n 
1 350 TYR n 
1 351 PRO n 
1 352 GLU n 
1 353 LEU n 
1 354 ASP n 
1 355 LYS n 
1 356 SER n 
1 357 LEU n 
1 358 GLY n 
1 359 LYS n 
1 360 PRO n 
1 361 LEU n 
1 362 ASN n 
1 363 GLU n 
1 364 MET n 
1 365 LYS n 
1 366 VAL n 
1 367 HIS n 
1 368 ASN n 
1 369 TRP n 
1 370 GLU n 
1 371 LEU n 
1 372 THR n 
1 373 ARG n 
1 374 ASN n 
1 375 TYR n 
1 376 GLU n 
1 377 HIS n 
1 378 ALA n 
1 379 SER n 
1 380 VAL n 
1 381 TRP n 
1 382 LEU n 
1 383 ASN n 
1 384 LEU n 
1 385 ALA n 
1 386 THR n 
1 387 LYS n 
1 388 GLU n 
1 389 ALA n 
1 390 LYS n 
1 391 ILE n 
1 392 ASN n 
1 393 TRP n 
1 394 LYS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   394 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 AXE80_08855 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Wenyingzhuangia fucanilytica' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     1790137 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -33 ?   ?   ?   A . n 
A 1 2   GLY 2   -32 ?   ?   ?   A . n 
A 1 3   SER 3   -31 ?   ?   ?   A . n 
A 1 4   SER 4   -30 ?   ?   ?   A . n 
A 1 5   HIS 5   -29 ?   ?   ?   A . n 
A 1 6   HIS 6   -28 ?   ?   ?   A . n 
A 1 7   HIS 7   -27 ?   ?   ?   A . n 
A 1 8   HIS 8   -26 ?   ?   ?   A . n 
A 1 9   HIS 9   -25 ?   ?   ?   A . n 
A 1 10  HIS 10  -24 ?   ?   ?   A . n 
A 1 11  SER 11  -23 ?   ?   ?   A . n 
A 1 12  SER 12  -22 ?   ?   ?   A . n 
A 1 13  GLY 13  -21 ?   ?   ?   A . n 
A 1 14  LEU 14  -20 ?   ?   ?   A . n 
A 1 15  VAL 15  -19 ?   ?   ?   A . n 
A 1 16  PRO 16  -18 ?   ?   ?   A . n 
A 1 17  ARG 17  -17 ?   ?   ?   A . n 
A 1 18  GLY 18  -16 ?   ?   ?   A . n 
A 1 19  SER 19  -15 ?   ?   ?   A . n 
A 1 20  HIS 20  -14 ?   ?   ?   A . n 
A 1 21  MET 21  -13 ?   ?   ?   A . n 
A 1 22  ALA 22  -12 ?   ?   ?   A . n 
A 1 23  SER 23  -11 ?   ?   ?   A . n 
A 1 24  MET 24  -10 ?   ?   ?   A . n 
A 1 25  THR 25  -9  ?   ?   ?   A . n 
A 1 26  GLY 26  -8  ?   ?   ?   A . n 
A 1 27  GLY 27  -7  ?   ?   ?   A . n 
A 1 28  GLN 28  -6  ?   ?   ?   A . n 
A 1 29  GLN 29  -5  ?   ?   ?   A . n 
A 1 30  MET 30  -4  ?   ?   ?   A . n 
A 1 31  GLY 31  -3  ?   ?   ?   A . n 
A 1 32  ARG 32  -2  ?   ?   ?   A . n 
A 1 33  GLY 33  -1  ?   ?   ?   A . n 
A 1 34  SER 34  0   ?   ?   ?   A . n 
A 1 35  GLN 35  1   ?   ?   ?   A . n 
A 1 36  SER 36  2   ?   ?   ?   A . n 
A 1 37  LYS 37  3   ?   ?   ?   A . n 
A 1 38  THR 38  4   ?   ?   ?   A . n 
A 1 39  ASN 39  5   ?   ?   ?   A . n 
A 1 40  LYS 40  6   ?   ?   ?   A . n 
A 1 41  ASP 41  7   7   ASP ASP A . n 
A 1 42  TYR 42  8   8   TYR TYR A . n 
A 1 43  TYR 43  9   9   TYR TYR A . n 
A 1 44  PRO 44  10  10  PRO PRO A . n 
A 1 45  GLU 45  11  11  GLU GLU A . n 
A 1 46  PHE 46  12  12  PHE PHE A . n 
A 1 47  SER 47  13  13  SER SER A . n 
A 1 48  TRP 48  14  14  TRP TRP A . n 
A 1 49  LYS 49  15  15  LYS LYS A . n 
A 1 50  THR 50  16  16  THR THR A . n 
A 1 51  VAL 51  17  17  VAL VAL A . n 
A 1 52  PRO 52  18  18  PRO PRO A . n 
A 1 53  VAL 53  19  19  VAL VAL A . n 
A 1 54  ALA 54  20  20  ALA ALA A . n 
A 1 55  PHE 55  21  21  PHE PHE A . n 
A 1 56  HIS 56  22  22  HIS HIS A . n 
A 1 57  PHE 57  23  23  PHE PHE A . n 
A 1 58  ALA 58  24  24  ALA ALA A . n 
A 1 59  LYS 59  25  25  LYS LYS A . n 
A 1 60  ARG 60  26  26  ARG ARG A . n 
A 1 61  ASN 61  27  27  ASN ASN A . n 
A 1 62  GLY 62  28  28  GLY GLY A . n 
A 1 63  LEU 63  29  29  LEU LEU A . n 
A 1 64  MET 64  30  30  MET MET A . n 
A 1 65  THR 65  31  31  THR THR A . n 
A 1 66  ASP 66  32  32  ASP ASP A . n 
A 1 67  LYS 67  33  33  LYS LYS A . n 
A 1 68  GLU 68  34  34  GLU GLU A . n 
A 1 69  LEU 69  35  35  LEU LEU A . n 
A 1 70  ASP 70  36  36  ASP ASP A . n 
A 1 71  PHE 71  37  37  PHE PHE A . n 
A 1 72  VAL 72  38  38  VAL VAL A . n 
A 1 73  THR 73  39  39  THR THR A . n 
A 1 74  SER 74  40  40  SER SER A . n 
A 1 75  HIS 75  41  41  HIS HIS A . n 
A 1 76  SER 76  42  42  SER SER A . n 
A 1 77  ASN 77  43  43  ASN ASN A . n 
A 1 78  PHE 78  44  44  PHE PHE A . n 
A 1 79  ILE 79  45  45  ILE ILE A . n 
A 1 80  VAL 80  46  46  VAL VAL A . n 
A 1 81  LEU 81  47  47  LEU LEU A . n 
A 1 82  GLU 82  48  48  GLU GLU A . n 
A 1 83  LYS 83  49  49  LYS LYS A . n 
A 1 84  GLY 84  50  50  GLY GLY A . n 
A 1 85  HIS 85  51  51  HIS HIS A . n 
A 1 86  GLY 86  52  52  GLY GLY A . n 
A 1 87  GLY 87  53  53  GLY GLY A . n 
A 1 88  ASP 88  54  54  ASP ASP A . n 
A 1 89  ILE 89  55  55  ILE ILE A . n 
A 1 90  ARG 90  56  56  ARG ARG A . n 
A 1 91  THR 91  57  57  THR THR A . n 
A 1 92  GLU 92  58  58  GLU GLU A . n 
A 1 93  LYS 93  59  59  LYS LYS A . n 
A 1 94  GLY 94  60  60  GLY GLY A . n 
A 1 95  ILE 95  61  61  ILE ILE A . n 
A 1 96  ASP 96  62  62  ASP ASP A . n 
A 1 97  ASN 97  63  63  ASN ASN A . n 
A 1 98  GLU 98  64  64  GLU GLU A . n 
A 1 99  ALA 99  65  65  ALA ALA A . n 
A 1 100 GLN 100 66  66  GLN GLN A . n 
A 1 101 ARG 101 67  67  ARG ARG A . n 
A 1 102 ILE 102 68  68  ILE ILE A . n 
A 1 103 LYS 103 69  69  LYS LYS A . n 
A 1 104 ASP 104 70  70  ASP ASP A . n 
A 1 105 ILE 105 71  71  ILE ILE A . n 
A 1 106 ASN 106 72  72  ASN ASN A . n 
A 1 107 PRO 107 73  73  PRO PRO A . n 
A 1 108 LYS 108 74  74  LYS LYS A . n 
A 1 109 ALA 109 75  75  ALA ALA A . n 
A 1 110 LYS 110 76  76  LYS LYS A . n 
A 1 111 VAL 111 77  77  VAL VAL A . n 
A 1 112 VAL 112 78  78  VAL VAL A . n 
A 1 113 PHE 113 79  79  PHE PHE A . n 
A 1 114 TYR 114 80  80  TYR TYR A . n 
A 1 115 TRP 115 81  81  TRP TRP A . n 
A 1 116 ASN 116 82  82  ASN ASN A . n 
A 1 117 ALA 117 83  83  ALA ALA A . n 
A 1 118 PHE 118 84  84  PHE PHE A . n 
A 1 119 LEU 119 85  85  LEU LEU A . n 
A 1 120 ASP 120 86  86  ASP ASP A . n 
A 1 121 TYR 121 87  87  TYR TYR A . n 
A 1 122 ASN 122 88  88  ASN ASN A . n 
A 1 123 LEU 123 89  89  LEU LEU A . n 
A 1 124 TYR 124 90  90  TYR TYR A . n 
A 1 125 ASP 125 91  91  ASP ASP A . n 
A 1 126 ALA 126 92  92  ALA ALA A . n 
A 1 127 HIS 127 93  93  HIS HIS A . n 
A 1 128 LYS 128 94  94  LYS LYS A . n 
A 1 129 GLU 129 95  95  GLU GLU A . n 
A 1 130 TYR 130 96  96  TYR TYR A . n 
A 1 131 GLU 131 97  97  GLU GLU A . n 
A 1 132 ASN 132 98  98  ASN ASN A . n 
A 1 133 HIS 133 99  99  HIS HIS A . n 
A 1 134 LYS 134 100 100 LYS LYS A . n 
A 1 135 GLU 135 101 101 GLU GLU A . n 
A 1 136 TRP 136 102 102 TRP TRP A . n 
A 1 137 TRP 137 103 103 TRP TRP A . n 
A 1 138 LEU 138 104 104 LEU LEU A . n 
A 1 139 LYS 139 105 105 LYS LYS A . n 
A 1 140 LYS 140 106 106 LYS LYS A . n 
A 1 141 LEU 141 107 107 LEU LEU A . n 
A 1 142 ASP 142 108 108 ASP ASP A . n 
A 1 143 GLY 143 109 109 GLY GLY A . n 
A 1 144 ASN 144 110 110 ASN ASN A . n 
A 1 145 TYR 145 111 111 TYR TYR A . n 
A 1 146 ASP 146 112 112 ASP ASP A . n 
A 1 147 TYR 147 113 113 TYR TYR A . n 
A 1 148 LYS 148 114 114 LYS LYS A . n 
A 1 149 SER 149 115 115 SER SER A . n 
A 1 150 ALA 150 116 116 ALA ALA A . n 
A 1 151 LYS 151 117 117 LYS LYS A . n 
A 1 152 VAL 152 118 118 VAL VAL A . n 
A 1 153 LYS 153 119 119 LYS LYS A . n 
A 1 154 ARG 154 120 120 ARG ARG A . n 
A 1 155 TYR 155 121 121 TYR TYR A . n 
A 1 156 ASP 156 122 122 ASP ASP A . n 
A 1 157 LEU 157 123 123 LEU LEU A . n 
A 1 158 SER 158 124 124 SER SER A . n 
A 1 159 ASN 159 125 125 ASN ASN A . n 
A 1 160 PRO 160 126 126 PRO PRO A . n 
A 1 161 ALA 161 127 127 ALA ALA A . n 
A 1 162 PHE 162 128 128 PHE PHE A . n 
A 1 163 ARG 163 129 129 ARG ARG A . n 
A 1 164 LYS 164 130 130 LYS LYS A . n 
A 1 165 TRP 165 131 131 TRP TRP A . n 
A 1 166 TRP 166 132 132 TRP TRP A . n 
A 1 167 VAL 167 133 133 VAL VAL A . n 
A 1 168 SER 168 134 134 SER SER A . n 
A 1 169 ILE 169 135 135 ILE ILE A . n 
A 1 170 ALA 170 136 136 ALA ALA A . n 
A 1 171 LYS 171 137 137 LYS LYS A . n 
A 1 172 LYS 172 138 138 LYS LYS A . n 
A 1 173 ALA 173 139 139 ALA ALA A . n 
A 1 174 VAL 174 140 140 VAL VAL A . n 
A 1 175 VAL 175 141 141 VAL VAL A . n 
A 1 176 ASP 176 142 142 ASP ASP A . n 
A 1 177 GLY 177 143 143 GLY GLY A . n 
A 1 178 HIS 178 144 144 HIS HIS A . n 
A 1 179 ALA 179 145 145 ALA ALA A . n 
A 1 180 ASP 180 146 146 ASP ASP A . n 
A 1 181 GLY 181 147 147 GLY GLY A . n 
A 1 182 VAL 182 148 148 VAL VAL A . n 
A 1 183 PHE 183 149 149 PHE PHE A . n 
A 1 184 MET 184 150 150 MET MET A . n 
A 1 185 ASP 185 151 151 ASP ASP A . n 
A 1 186 ALA 186 152 152 ALA ALA A . n 
A 1 187 PHE 187 153 153 PHE PHE A . n 
A 1 188 ILE 188 154 154 ILE ILE A . n 
A 1 189 GLN 189 155 155 GLN GLN A . n 
A 1 190 VAL 190 156 156 VAL VAL A . n 
A 1 191 ILE 191 157 157 ILE ILE A . n 
A 1 192 ASN 192 158 158 ASN ASN A . n 
A 1 193 LYS 193 159 159 LYS LYS A . n 
A 1 194 GLY 194 160 160 GLY GLY A . n 
A 1 195 ASN 195 161 161 ASN ASN A . n 
A 1 196 ILE 196 162 162 ILE ILE A . n 
A 1 197 GLU 197 163 163 GLU GLU A . n 
A 1 198 LEU 198 164 164 LEU LEU A . n 
A 1 199 TRP 199 165 165 TRP TRP A . n 
A 1 200 GLY 200 166 166 GLY GLY A . n 
A 1 201 GLN 201 167 167 GLN GLN A . n 
A 1 202 LYS 202 168 168 LYS LYS A . n 
A 1 203 LYS 203 169 169 LYS LYS A . n 
A 1 204 TYR 204 170 170 TYR TYR A . n 
A 1 205 ASP 205 171 171 ASP ASP A . n 
A 1 206 ALA 206 172 172 ALA ALA A . n 
A 1 207 ILE 207 173 173 ILE ILE A . n 
A 1 208 GLN 208 174 174 GLN GLN A . n 
A 1 209 GLN 209 175 175 GLN GLN A . n 
A 1 210 GLY 210 176 176 GLY GLY A . n 
A 1 211 LEU 211 177 177 LEU LEU A . n 
A 1 212 LYS 212 178 178 LYS LYS A . n 
A 1 213 ASP 213 179 179 ASP ASP A . n 
A 1 214 LEU 214 180 180 LEU LEU A . n 
A 1 215 ILE 215 181 181 ILE ILE A . n 
A 1 216 ALA 216 182 182 ALA ALA A . n 
A 1 217 GLU 217 183 183 GLU GLU A . n 
A 1 218 THR 218 184 184 THR THR A . n 
A 1 219 ARG 219 185 185 ARG ARG A . n 
A 1 220 ALA 220 186 186 ALA ALA A . n 
A 1 221 ALA 221 187 187 ALA ALA A . n 
A 1 222 ILE 222 188 188 ILE ILE A . n 
A 1 223 GLY 223 189 189 GLY GLY A . n 
A 1 224 GLU 224 190 190 GLU GLU A . n 
A 1 225 ASP 225 191 191 ASP ASP A . n 
A 1 226 HIS 226 192 192 HIS HIS A . n 
A 1 227 LEU 227 193 193 LEU LEU A . n 
A 1 228 ILE 228 194 194 ILE ILE A . n 
A 1 229 VAL 229 195 195 VAL VAL A . n 
A 1 230 TYR 230 196 196 TYR TYR A . n 
A 1 231 ASN 231 197 197 ASN ASN A . n 
A 1 232 GLY 232 198 198 GLY GLY A . n 
A 1 233 ILE 233 199 199 ILE ILE A . n 
A 1 234 ARG 234 200 200 ARG ARG A . n 
A 1 235 SER 235 201 201 SER SER A . n 
A 1 236 ILE 236 202 202 ILE ILE A . n 
A 1 237 PRO 237 203 203 PRO PRO A . n 
A 1 238 ASN 238 204 204 ASN ASN A . n 
A 1 239 ARG 239 205 205 ARG ARG A . n 
A 1 240 ASN 240 206 206 ASN ASN A . n 
A 1 241 VAL 241 207 207 VAL VAL A . n 
A 1 242 GLY 242 208 208 GLY GLY A . n 
A 1 243 ASN 243 209 209 ASN ASN A . n 
A 1 244 ASP 244 210 210 ASP ASP A . n 
A 1 245 PHE 245 211 211 PHE PHE A . n 
A 1 246 PRO 246 212 212 PRO PRO A . n 
A 1 247 GLU 247 213 213 GLU GLU A . n 
A 1 248 HIS 248 214 214 HIS HIS A . n 
A 1 249 THR 249 215 215 THR THR A . n 
A 1 250 ASP 250 216 216 ASP ASP A . n 
A 1 251 ALA 251 217 217 ALA ALA A . n 
A 1 252 VAL 252 218 218 VAL VAL A . n 
A 1 253 MET 253 219 219 MET MET A . n 
A 1 254 ILE 254 220 220 ILE ILE A . n 
A 1 255 GLU 255 221 221 GLU GLU A . n 
A 1 256 HIS 256 222 222 HIS HIS A . n 
A 1 257 PHE 257 223 223 PHE PHE A . n 
A 1 258 ALA 258 224 224 ALA ALA A . n 
A 1 259 ASN 259 225 225 ASN ASN A . n 
A 1 260 PHE 260 226 226 PHE PHE A . n 
A 1 261 GLN 261 227 227 GLN GLN A . n 
A 1 262 SER 262 228 228 SER SER A . n 
A 1 263 LYS 263 229 229 LYS LYS A . n 
A 1 264 SER 264 230 230 SER SER A . n 
A 1 265 LYS 265 231 231 LYS LYS A . n 
A 1 266 GLU 266 232 232 GLU GLU A . n 
A 1 267 SER 267 233 233 SER SER A . n 
A 1 268 MET 268 234 234 MET MET A . n 
A 1 269 LEU 269 235 235 LEU LEU A . n 
A 1 270 GLN 270 236 236 GLN GLN A . n 
A 1 271 ASP 271 237 237 ASP ASP A . n 
A 1 272 ILE 272 238 238 ILE ILE A . n 
A 1 273 LEU 273 239 239 LEU LEU A . n 
A 1 274 GLU 274 240 240 GLU GLU A . n 
A 1 275 MET 275 241 241 MET MET A . n 
A 1 276 GLU 276 242 242 GLU GLU A . n 
A 1 277 LYS 277 243 243 LYS LYS A . n 
A 1 278 ALA 278 244 244 ALA ALA A . n 
A 1 279 GLY 279 245 245 GLY GLY A . n 
A 1 280 LYS 280 246 246 LYS LYS A . n 
A 1 281 THR 281 247 247 THR THR A . n 
A 1 282 GLY 282 248 248 GLY GLY A . n 
A 1 283 LYS 283 249 249 LYS LYS A . n 
A 1 284 ILE 284 250 250 ILE ILE A . n 
A 1 285 VAL 285 251 251 VAL VAL A . n 
A 1 286 VAL 286 252 252 VAL VAL A . n 
A 1 287 PHE 287 253 253 PHE PHE A . n 
A 1 288 LYS 288 254 254 LYS LYS A . n 
A 1 289 ALA 289 255 255 ALA ALA A . n 
A 1 290 TRP 290 256 256 TRP TRP A . n 
A 1 291 PRO 291 257 257 PRO PRO A . n 
A 1 292 ASN 292 258 258 ASN ASN A . n 
A 1 293 GLU 293 259 259 GLU GLU A . n 
A 1 294 HIS 294 260 260 HIS HIS A . n 
A 1 295 SER 295 261 261 SER SER A . n 
A 1 296 TRP 296 262 262 TRP TRP A . n 
A 1 297 ILE 297 263 263 ILE ILE A . n 
A 1 298 ASP 298 264 264 ASP ASP A . n 
A 1 299 LYS 299 265 265 LYS LYS A . n 
A 1 300 ASN 300 266 266 ASN ASN A . n 
A 1 301 PHE 301 267 267 PHE PHE A . n 
A 1 302 MET 302 268 268 MET MET A . n 
A 1 303 ALA 303 269 269 ALA ALA A . n 
A 1 304 LYS 304 270 270 LYS LYS A . n 
A 1 305 PRO 305 271 271 PRO PRO A . n 
A 1 306 LEU 306 272 272 LEU LEU A . n 
A 1 307 GLN 307 273 273 GLN GLN A . n 
A 1 308 GLU 308 274 274 GLU GLU A . n 
A 1 309 LYS 309 275 275 LYS LYS A . n 
A 1 310 ARG 310 276 276 ARG ARG A . n 
A 1 311 LYS 311 277 277 LYS LYS A . n 
A 1 312 ILE 312 278 278 ILE ILE A . n 
A 1 313 ALA 313 279 279 ALA ALA A . n 
A 1 314 ARG 314 280 280 ARG ARG A . n 
A 1 315 ALA 315 281 281 ALA ALA A . n 
A 1 316 ASN 316 282 282 ASN ASN A . n 
A 1 317 ILE 317 283 283 ILE ILE A . n 
A 1 318 THR 318 284 284 THR THR A . n 
A 1 319 PHE 319 285 285 PHE PHE A . n 
A 1 320 PRO 320 286 286 PRO PRO A . n 
A 1 321 LEU 321 287 287 LEU LEU A . n 
A 1 322 ALA 322 288 288 ALA ALA A . n 
A 1 323 ALA 323 289 289 ALA ALA A . n 
A 1 324 PHE 324 290 290 PHE PHE A . n 
A 1 325 LEU 325 291 291 LEU LEU A . n 
A 1 326 ALA 326 292 292 ALA ALA A . n 
A 1 327 GLY 327 293 293 GLY GLY A . n 
A 1 328 ALA 328 294 294 ALA ALA A . n 
A 1 329 GLN 329 295 295 GLN GLN A . n 
A 1 330 GLU 330 296 296 GLU GLU A . n 
A 1 331 ASN 331 297 297 ASN ASN A . n 
A 1 332 SER 332 298 298 SER SER A . n 
A 1 333 TYR 333 299 299 TYR TYR A . n 
A 1 334 PHE 334 300 300 PHE PHE A . n 
A 1 335 ILE 335 301 301 ILE ILE A . n 
A 1 336 TYR 336 302 302 TYR TYR A . n 
A 1 337 ASN 337 303 303 ASN ASN A . n 
A 1 338 TRP 338 304 304 TRP TRP A . n 
A 1 339 GLY 339 305 305 GLY GLY A . n 
A 1 340 TYR 340 306 306 TYR TYR A . n 
A 1 341 ARG 341 307 307 ARG ARG A . n 
A 1 342 MET 342 308 308 MET MET A . n 
A 1 343 ASP 343 309 309 ASP ASP A . n 
A 1 344 ASP 344 310 310 ASP ASP A . n 
A 1 345 GLY 345 311 311 GLY GLY A . n 
A 1 346 GLY 346 312 312 GLY GLY A . n 
A 1 347 LEU 347 313 313 LEU LEU A . n 
A 1 348 GLU 348 314 314 GLU GLU A . n 
A 1 349 TRP 349 315 315 TRP TRP A . n 
A 1 350 TYR 350 316 316 TYR TYR A . n 
A 1 351 PRO 351 317 317 PRO PRO A . n 
A 1 352 GLU 352 318 318 GLU GLU A . n 
A 1 353 LEU 353 319 319 LEU LEU A . n 
A 1 354 ASP 354 320 320 ASP ASP A . n 
A 1 355 LYS 355 321 321 LYS LYS A . n 
A 1 356 SER 356 322 322 SER SER A . n 
A 1 357 LEU 357 323 323 LEU LEU A . n 
A 1 358 GLY 358 324 324 GLY GLY A . n 
A 1 359 LYS 359 325 325 LYS LYS A . n 
A 1 360 PRO 360 326 326 PRO PRO A . n 
A 1 361 LEU 361 327 327 LEU LEU A . n 
A 1 362 ASN 362 328 328 ASN ASN A . n 
A 1 363 GLU 363 329 329 GLU GLU A . n 
A 1 364 MET 364 330 330 MET MET A . n 
A 1 365 LYS 365 331 331 LYS LYS A . n 
A 1 366 VAL 366 332 332 VAL VAL A . n 
A 1 367 HIS 367 333 333 HIS HIS A . n 
A 1 368 ASN 368 334 334 ASN ASN A . n 
A 1 369 TRP 369 335 335 TRP TRP A . n 
A 1 370 GLU 370 336 336 GLU GLU A . n 
A 1 371 LEU 371 337 337 LEU LEU A . n 
A 1 372 THR 372 338 338 THR THR A . n 
A 1 373 ARG 373 339 339 ARG ARG A . n 
A 1 374 ASN 374 340 340 ASN ASN A . n 
A 1 375 TYR 375 341 341 TYR TYR A . n 
A 1 376 GLU 376 342 342 GLU GLU A . n 
A 1 377 HIS 377 343 343 HIS HIS A . n 
A 1 378 ALA 378 344 344 ALA ALA A . n 
A 1 379 SER 379 345 345 SER SER A . n 
A 1 380 VAL 380 346 346 VAL VAL A . n 
A 1 381 TRP 381 347 347 TRP TRP A . n 
A 1 382 LEU 382 348 348 LEU LEU A . n 
A 1 383 ASN 383 349 349 ASN ASN A . n 
A 1 384 LEU 384 350 350 LEU LEU A . n 
A 1 385 ALA 385 351 351 ALA ALA A . n 
A 1 386 THR 386 352 352 THR THR A . n 
A 1 387 LYS 387 353 353 LYS LYS A . n 
A 1 388 GLU 388 354 354 GLU GLU A . n 
A 1 389 ALA 389 355 355 ALA ALA A . n 
A 1 390 LYS 390 356 356 LYS LYS A . n 
A 1 391 ILE 391 357 357 ILE ILE A . n 
A 1 392 ASN 392 358 358 ASN ASN A . n 
A 1 393 TRP 393 359 359 TRP TRP A . n 
A 1 394 LYS 394 360 360 LYS LYS A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 HOH 1   401 208 HOH HOH A . 
B 2 HOH 2   402 161 HOH HOH A . 
B 2 HOH 3   403 137 HOH HOH A . 
B 2 HOH 4   404 26  HOH HOH A . 
B 2 HOH 5   405 217 HOH HOH A . 
B 2 HOH 6   406 364 HOH HOH A . 
B 2 HOH 7   407 200 HOH HOH A . 
B 2 HOH 8   408 205 HOH HOH A . 
B 2 HOH 9   409 275 HOH HOH A . 
B 2 HOH 10  410 179 HOH HOH A . 
B 2 HOH 11  411 316 HOH HOH A . 
B 2 HOH 12  412 327 HOH HOH A . 
B 2 HOH 13  413 122 HOH HOH A . 
B 2 HOH 14  414 22  HOH HOH A . 
B 2 HOH 15  415 370 HOH HOH A . 
B 2 HOH 16  416 284 HOH HOH A . 
B 2 HOH 17  417 105 HOH HOH A . 
B 2 HOH 18  418 290 HOH HOH A . 
B 2 HOH 19  419 390 HOH HOH A . 
B 2 HOH 20  420 272 HOH HOH A . 
B 2 HOH 21  421 375 HOH HOH A . 
B 2 HOH 22  422 378 HOH HOH A . 
B 2 HOH 23  423 54  HOH HOH A . 
B 2 HOH 24  424 92  HOH HOH A . 
B 2 HOH 25  425 331 HOH HOH A . 
B 2 HOH 26  426 39  HOH HOH A . 
B 2 HOH 27  427 111 HOH HOH A . 
B 2 HOH 28  428 90  HOH HOH A . 
B 2 HOH 29  429 258 HOH HOH A . 
B 2 HOH 30  430 36  HOH HOH A . 
B 2 HOH 31  431 33  HOH HOH A . 
B 2 HOH 32  432 16  HOH HOH A . 
B 2 HOH 33  433 9   HOH HOH A . 
B 2 HOH 34  434 31  HOH HOH A . 
B 2 HOH 35  435 344 HOH HOH A . 
B 2 HOH 36  436 209 HOH HOH A . 
B 2 HOH 37  437 296 HOH HOH A . 
B 2 HOH 38  438 190 HOH HOH A . 
B 2 HOH 39  439 220 HOH HOH A . 
B 2 HOH 40  440 162 HOH HOH A . 
B 2 HOH 41  441 157 HOH HOH A . 
B 2 HOH 42  442 178 HOH HOH A . 
B 2 HOH 43  443 128 HOH HOH A . 
B 2 HOH 44  444 371 HOH HOH A . 
B 2 HOH 45  445 158 HOH HOH A . 
B 2 HOH 46  446 277 HOH HOH A . 
B 2 HOH 47  447 302 HOH HOH A . 
B 2 HOH 48  448 35  HOH HOH A . 
B 2 HOH 49  449 23  HOH HOH A . 
B 2 HOH 50  450 341 HOH HOH A . 
B 2 HOH 51  451 168 HOH HOH A . 
B 2 HOH 52  452 107 HOH HOH A . 
B 2 HOH 53  453 227 HOH HOH A . 
B 2 HOH 54  454 389 HOH HOH A . 
B 2 HOH 55  455 72  HOH HOH A . 
B 2 HOH 56  456 183 HOH HOH A . 
B 2 HOH 57  457 289 HOH HOH A . 
B 2 HOH 58  458 4   HOH HOH A . 
B 2 HOH 59  459 279 HOH HOH A . 
B 2 HOH 60  460 10  HOH HOH A . 
B 2 HOH 61  461 20  HOH HOH A . 
B 2 HOH 62  462 207 HOH HOH A . 
B 2 HOH 63  463 56  HOH HOH A . 
B 2 HOH 64  464 93  HOH HOH A . 
B 2 HOH 65  465 300 HOH HOH A . 
B 2 HOH 66  466 75  HOH HOH A . 
B 2 HOH 67  467 133 HOH HOH A . 
B 2 HOH 68  468 12  HOH HOH A . 
B 2 HOH 69  469 32  HOH HOH A . 
B 2 HOH 70  470 182 HOH HOH A . 
B 2 HOH 71  471 325 HOH HOH A . 
B 2 HOH 72  472 211 HOH HOH A . 
B 2 HOH 73  473 117 HOH HOH A . 
B 2 HOH 74  474 13  HOH HOH A . 
B 2 HOH 75  475 125 HOH HOH A . 
B 2 HOH 76  476 139 HOH HOH A . 
B 2 HOH 77  477 14  HOH HOH A . 
B 2 HOH 78  478 138 HOH HOH A . 
B 2 HOH 79  479 197 HOH HOH A . 
B 2 HOH 80  480 57  HOH HOH A . 
B 2 HOH 81  481 201 HOH HOH A . 
B 2 HOH 82  482 40  HOH HOH A . 
B 2 HOH 83  483 318 HOH HOH A . 
B 2 HOH 84  484 382 HOH HOH A . 
B 2 HOH 85  485 69  HOH HOH A . 
B 2 HOH 86  486 5   HOH HOH A . 
B 2 HOH 87  487 159 HOH HOH A . 
B 2 HOH 88  488 8   HOH HOH A . 
B 2 HOH 89  489 146 HOH HOH A . 
B 2 HOH 90  490 165 HOH HOH A . 
B 2 HOH 91  491 253 HOH HOH A . 
B 2 HOH 92  492 74  HOH HOH A . 
B 2 HOH 93  493 215 HOH HOH A . 
B 2 HOH 94  494 37  HOH HOH A . 
B 2 HOH 95  495 314 HOH HOH A . 
B 2 HOH 96  496 145 HOH HOH A . 
B 2 HOH 97  497 393 HOH HOH A . 
B 2 HOH 98  498 324 HOH HOH A . 
B 2 HOH 99  499 124 HOH HOH A . 
B 2 HOH 100 500 76  HOH HOH A . 
B 2 HOH 101 501 102 HOH HOH A . 
B 2 HOH 102 502 2   HOH HOH A . 
B 2 HOH 103 503 80  HOH HOH A . 
B 2 HOH 104 504 71  HOH HOH A . 
B 2 HOH 105 505 114 HOH HOH A . 
B 2 HOH 106 506 58  HOH HOH A . 
B 2 HOH 107 507 1   HOH HOH A . 
B 2 HOH 108 508 266 HOH HOH A . 
B 2 HOH 109 509 28  HOH HOH A . 
B 2 HOH 110 510 11  HOH HOH A . 
B 2 HOH 111 511 172 HOH HOH A . 
B 2 HOH 112 512 273 HOH HOH A . 
B 2 HOH 113 513 144 HOH HOH A . 
B 2 HOH 114 514 311 HOH HOH A . 
B 2 HOH 115 515 30  HOH HOH A . 
B 2 HOH 116 516 191 HOH HOH A . 
B 2 HOH 117 517 299 HOH HOH A . 
B 2 HOH 118 518 360 HOH HOH A . 
B 2 HOH 119 519 164 HOH HOH A . 
B 2 HOH 120 520 89  HOH HOH A . 
B 2 HOH 121 521 81  HOH HOH A . 
B 2 HOH 122 522 189 HOH HOH A . 
B 2 HOH 123 523 47  HOH HOH A . 
B 2 HOH 124 524 304 HOH HOH A . 
B 2 HOH 125 525 62  HOH HOH A . 
B 2 HOH 126 526 45  HOH HOH A . 
B 2 HOH 127 527 295 HOH HOH A . 
B 2 HOH 128 528 149 HOH HOH A . 
B 2 HOH 129 529 254 HOH HOH A . 
B 2 HOH 130 530 63  HOH HOH A . 
B 2 HOH 131 531 19  HOH HOH A . 
B 2 HOH 132 532 374 HOH HOH A . 
B 2 HOH 133 533 100 HOH HOH A . 
B 2 HOH 134 534 48  HOH HOH A . 
B 2 HOH 135 535 223 HOH HOH A . 
B 2 HOH 136 536 225 HOH HOH A . 
B 2 HOH 137 537 55  HOH HOH A . 
B 2 HOH 138 538 248 HOH HOH A . 
B 2 HOH 139 539 113 HOH HOH A . 
B 2 HOH 140 540 373 HOH HOH A . 
B 2 HOH 141 541 306 HOH HOH A . 
B 2 HOH 142 542 372 HOH HOH A . 
B 2 HOH 143 543 184 HOH HOH A . 
B 2 HOH 144 544 91  HOH HOH A . 
B 2 HOH 145 545 294 HOH HOH A . 
B 2 HOH 146 546 400 HOH HOH A . 
B 2 HOH 147 547 83  HOH HOH A . 
B 2 HOH 148 548 86  HOH HOH A . 
B 2 HOH 149 549 155 HOH HOH A . 
B 2 HOH 150 550 386 HOH HOH A . 
B 2 HOH 151 551 85  HOH HOH A . 
B 2 HOH 152 552 43  HOH HOH A . 
B 2 HOH 153 553 123 HOH HOH A . 
B 2 HOH 154 554 221 HOH HOH A . 
B 2 HOH 155 555 282 HOH HOH A . 
B 2 HOH 156 556 42  HOH HOH A . 
B 2 HOH 157 557 101 HOH HOH A . 
B 2 HOH 158 558 303 HOH HOH A . 
B 2 HOH 159 559 24  HOH HOH A . 
B 2 HOH 160 560 336 HOH HOH A . 
B 2 HOH 161 561 7   HOH HOH A . 
B 2 HOH 162 562 15  HOH HOH A . 
B 2 HOH 163 563 70  HOH HOH A . 
B 2 HOH 164 564 73  HOH HOH A . 
B 2 HOH 165 565 50  HOH HOH A . 
B 2 HOH 166 566 152 HOH HOH A . 
B 2 HOH 167 567 335 HOH HOH A . 
B 2 HOH 168 568 3   HOH HOH A . 
B 2 HOH 169 569 167 HOH HOH A . 
B 2 HOH 170 570 29  HOH HOH A . 
B 2 HOH 171 571 228 HOH HOH A . 
B 2 HOH 172 572 234 HOH HOH A . 
B 2 HOH 173 573 193 HOH HOH A . 
B 2 HOH 174 574 287 HOH HOH A . 
B 2 HOH 175 575 230 HOH HOH A . 
B 2 HOH 176 576 51  HOH HOH A . 
B 2 HOH 177 577 338 HOH HOH A . 
B 2 HOH 178 578 121 HOH HOH A . 
B 2 HOH 179 579 112 HOH HOH A . 
B 2 HOH 180 580 59  HOH HOH A . 
B 2 HOH 181 581 109 HOH HOH A . 
B 2 HOH 182 582 195 HOH HOH A . 
B 2 HOH 183 583 270 HOH HOH A . 
B 2 HOH 184 584 185 HOH HOH A . 
B 2 HOH 185 585 301 HOH HOH A . 
B 2 HOH 186 586 235 HOH HOH A . 
B 2 HOH 187 587 259 HOH HOH A . 
B 2 HOH 188 588 256 HOH HOH A . 
B 2 HOH 189 589 226 HOH HOH A . 
B 2 HOH 190 590 188 HOH HOH A . 
B 2 HOH 191 591 64  HOH HOH A . 
B 2 HOH 192 592 104 HOH HOH A . 
B 2 HOH 193 593 95  HOH HOH A . 
B 2 HOH 194 594 17  HOH HOH A . 
B 2 HOH 195 595 269 HOH HOH A . 
B 2 HOH 196 596 177 HOH HOH A . 
B 2 HOH 197 597 136 HOH HOH A . 
B 2 HOH 198 598 252 HOH HOH A . 
B 2 HOH 199 599 88  HOH HOH A . 
B 2 HOH 200 600 329 HOH HOH A . 
B 2 HOH 201 601 21  HOH HOH A . 
B 2 HOH 202 602 25  HOH HOH A . 
B 2 HOH 203 603 61  HOH HOH A . 
B 2 HOH 204 604 322 HOH HOH A . 
B 2 HOH 205 605 108 HOH HOH A . 
B 2 HOH 206 606 271 HOH HOH A . 
B 2 HOH 207 607 224 HOH HOH A . 
B 2 HOH 208 608 219 HOH HOH A . 
B 2 HOH 209 609 337 HOH HOH A . 
B 2 HOH 210 610 202 HOH HOH A . 
B 2 HOH 211 611 6   HOH HOH A . 
B 2 HOH 212 612 84  HOH HOH A . 
B 2 HOH 213 613 79  HOH HOH A . 
B 2 HOH 214 614 66  HOH HOH A . 
B 2 HOH 215 615 116 HOH HOH A . 
B 2 HOH 216 616 246 HOH HOH A . 
B 2 HOH 217 617 135 HOH HOH A . 
B 2 HOH 218 618 53  HOH HOH A . 
B 2 HOH 219 619 321 HOH HOH A . 
B 2 HOH 220 620 147 HOH HOH A . 
B 2 HOH 221 621 333 HOH HOH A . 
B 2 HOH 222 622 27  HOH HOH A . 
B 2 HOH 223 623 218 HOH HOH A . 
B 2 HOH 224 624 130 HOH HOH A . 
B 2 HOH 225 625 180 HOH HOH A . 
B 2 HOH 226 626 99  HOH HOH A . 
B 2 HOH 227 627 77  HOH HOH A . 
B 2 HOH 228 628 120 HOH HOH A . 
B 2 HOH 229 629 355 HOH HOH A . 
B 2 HOH 230 630 171 HOH HOH A . 
B 2 HOH 231 631 192 HOH HOH A . 
B 2 HOH 232 632 140 HOH HOH A . 
B 2 HOH 233 633 214 HOH HOH A . 
B 2 HOH 234 634 297 HOH HOH A . 
B 2 HOH 235 635 41  HOH HOH A . 
B 2 HOH 236 636 210 HOH HOH A . 
B 2 HOH 237 637 119 HOH HOH A . 
B 2 HOH 238 638 194 HOH HOH A . 
B 2 HOH 239 639 154 HOH HOH A . 
B 2 HOH 240 640 357 HOH HOH A . 
B 2 HOH 241 641 134 HOH HOH A . 
B 2 HOH 242 642 97  HOH HOH A . 
B 2 HOH 243 643 52  HOH HOH A . 
B 2 HOH 244 644 18  HOH HOH A . 
B 2 HOH 245 645 229 HOH HOH A . 
B 2 HOH 246 646 163 HOH HOH A . 
B 2 HOH 247 647 187 HOH HOH A . 
B 2 HOH 248 648 204 HOH HOH A . 
B 2 HOH 249 649 312 HOH HOH A . 
B 2 HOH 250 650 231 HOH HOH A . 
B 2 HOH 251 651 354 HOH HOH A . 
B 2 HOH 252 652 115 HOH HOH A . 
B 2 HOH 253 653 237 HOH HOH A . 
B 2 HOH 254 654 143 HOH HOH A . 
B 2 HOH 255 655 241 HOH HOH A . 
B 2 HOH 256 656 38  HOH HOH A . 
B 2 HOH 257 657 49  HOH HOH A . 
B 2 HOH 258 658 264 HOH HOH A . 
B 2 HOH 259 659 391 HOH HOH A . 
B 2 HOH 260 660 132 HOH HOH A . 
B 2 HOH 261 661 385 HOH HOH A . 
B 2 HOH 262 662 236 HOH HOH A . 
B 2 HOH 263 663 286 HOH HOH A . 
B 2 HOH 264 664 320 HOH HOH A . 
B 2 HOH 265 665 348 HOH HOH A . 
B 2 HOH 266 666 326 HOH HOH A . 
B 2 HOH 267 667 196 HOH HOH A . 
B 2 HOH 268 668 198 HOH HOH A . 
B 2 HOH 269 669 169 HOH HOH A . 
B 2 HOH 270 670 340 HOH HOH A . 
B 2 HOH 271 671 216 HOH HOH A . 
B 2 HOH 272 672 363 HOH HOH A . 
B 2 HOH 273 673 118 HOH HOH A . 
B 2 HOH 274 674 313 HOH HOH A . 
B 2 HOH 275 675 44  HOH HOH A . 
B 2 HOH 276 676 309 HOH HOH A . 
B 2 HOH 277 677 131 HOH HOH A . 
B 2 HOH 278 678 46  HOH HOH A . 
B 2 HOH 279 679 366 HOH HOH A . 
B 2 HOH 280 680 150 HOH HOH A . 
B 2 HOH 281 681 249 HOH HOH A . 
B 2 HOH 282 682 181 HOH HOH A . 
B 2 HOH 283 683 353 HOH HOH A . 
B 2 HOH 284 684 233 HOH HOH A . 
B 2 HOH 285 685 399 HOH HOH A . 
B 2 HOH 286 686 308 HOH HOH A . 
B 2 HOH 287 687 176 HOH HOH A . 
B 2 HOH 288 688 356 HOH HOH A . 
B 2 HOH 289 689 174 HOH HOH A . 
B 2 HOH 290 690 276 HOH HOH A . 
B 2 HOH 291 691 307 HOH HOH A . 
B 2 HOH 292 692 153 HOH HOH A . 
B 2 HOH 293 693 261 HOH HOH A . 
B 2 HOH 294 694 186 HOH HOH A . 
B 2 HOH 295 695 232 HOH HOH A . 
B 2 HOH 296 696 369 HOH HOH A . 
B 2 HOH 297 697 332 HOH HOH A . 
B 2 HOH 298 698 238 HOH HOH A . 
B 2 HOH 299 699 343 HOH HOH A . 
B 2 HOH 300 700 213 HOH HOH A . 
B 2 HOH 301 701 166 HOH HOH A . 
B 2 HOH 302 702 339 HOH HOH A . 
B 2 HOH 303 703 240 HOH HOH A . 
B 2 HOH 304 704 239 HOH HOH A . 
B 2 HOH 305 705 175 HOH HOH A . 
B 2 HOH 306 706 285 HOH HOH A . 
B 2 HOH 307 707 250 HOH HOH A . 
B 2 HOH 308 708 156 HOH HOH A . 
B 2 HOH 309 709 106 HOH HOH A . 
B 2 HOH 310 710 392 HOH HOH A . 
B 2 HOH 311 711 98  HOH HOH A . 
B 2 HOH 312 712 206 HOH HOH A . 
B 2 HOH 313 713 402 HOH HOH A . 
B 2 HOH 314 714 351 HOH HOH A . 
B 2 HOH 315 715 199 HOH HOH A . 
B 2 HOH 316 716 361 HOH HOH A . 
B 2 HOH 317 717 268 HOH HOH A . 
B 2 HOH 318 718 403 HOH HOH A . 
B 2 HOH 319 719 222 HOH HOH A . 
B 2 HOH 320 720 126 HOH HOH A . 
B 2 HOH 321 721 245 HOH HOH A . 
B 2 HOH 322 722 151 HOH HOH A . 
B 2 HOH 323 723 352 HOH HOH A . 
B 2 HOH 324 724 170 HOH HOH A . 
B 2 HOH 325 725 293 HOH HOH A . 
B 2 HOH 326 726 291 HOH HOH A . 
B 2 HOH 327 727 349 HOH HOH A . 
B 2 HOH 328 728 358 HOH HOH A . 
B 2 HOH 329 729 298 HOH HOH A . 
B 2 HOH 330 730 383 HOH HOH A . 
B 2 HOH 331 731 67  HOH HOH A . 
B 2 HOH 332 732 377 HOH HOH A . 
B 2 HOH 333 733 262 HOH HOH A . 
B 2 HOH 334 734 315 HOH HOH A . 
B 2 HOH 335 735 396 HOH HOH A . 
B 2 HOH 336 736 319 HOH HOH A . 
B 2 HOH 337 737 68  HOH HOH A . 
B 2 HOH 338 738 160 HOH HOH A . 
B 2 HOH 339 739 384 HOH HOH A . 
B 2 HOH 340 740 342 HOH HOH A . 
B 2 HOH 341 741 103 HOH HOH A . 
B 2 HOH 342 742 362 HOH HOH A . 
B 2 HOH 343 743 255 HOH HOH A . 
B 2 HOH 344 744 323 HOH HOH A . 
B 2 HOH 345 745 381 HOH HOH A . 
B 2 HOH 346 746 368 HOH HOH A . 
B 2 HOH 347 747 379 HOH HOH A . 
B 2 HOH 348 748 283 HOH HOH A . 
B 2 HOH 349 749 278 HOH HOH A . 
B 2 HOH 350 750 347 HOH HOH A . 
B 2 HOH 351 751 398 HOH HOH A . 
B 2 HOH 352 752 141 HOH HOH A . 
B 2 HOH 353 753 281 HOH HOH A . 
B 2 HOH 354 754 265 HOH HOH A . 
B 2 HOH 355 755 330 HOH HOH A . 
B 2 HOH 356 756 82  HOH HOH A . 
B 2 HOH 357 757 328 HOH HOH A . 
B 2 HOH 358 758 317 HOH HOH A . 
B 2 HOH 359 759 387 HOH HOH A . 
B 2 HOH 360 760 203 HOH HOH A . 
B 2 HOH 361 761 267 HOH HOH A . 
B 2 HOH 362 762 346 HOH HOH A . 
B 2 HOH 363 763 274 HOH HOH A . 
B 2 HOH 364 764 292 HOH HOH A . 
B 2 HOH 365 765 173 HOH HOH A . 
B 2 HOH 366 766 87  HOH HOH A . 
B 2 HOH 367 767 257 HOH HOH A . 
B 2 HOH 368 768 243 HOH HOH A . 
B 2 HOH 369 769 260 HOH HOH A . 
B 2 HOH 370 770 365 HOH HOH A . 
B 2 HOH 371 771 96  HOH HOH A . 
B 2 HOH 372 772 367 HOH HOH A . 
B 2 HOH 373 773 334 HOH HOH A . 
B 2 HOH 374 774 397 HOH HOH A . 
B 2 HOH 375 775 247 HOH HOH A . 
B 2 HOH 376 776 94  HOH HOH A . 
B 2 HOH 377 777 305 HOH HOH A . 
B 2 HOH 378 778 127 HOH HOH A . 
B 2 HOH 379 779 244 HOH HOH A . 
B 2 HOH 380 780 129 HOH HOH A . 
B 2 HOH 381 781 345 HOH HOH A . 
B 2 HOH 382 782 263 HOH HOH A . 
B 2 HOH 383 783 251 HOH HOH A . 
B 2 HOH 384 784 65  HOH HOH A . 
B 2 HOH 385 785 395 HOH HOH A . 
B 2 HOH 386 786 142 HOH HOH A . 
B 2 HOH 387 787 78  HOH HOH A . 
B 2 HOH 388 788 110 HOH HOH A . 
B 2 HOH 389 789 148 HOH HOH A . 
B 2 HOH 390 790 310 HOH HOH A . 
B 2 HOH 391 791 350 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A LYS 15  ? CG  ? A LYS 49  CG  
2  1 Y 1 A LYS 15  ? CD  ? A LYS 49  CD  
3  1 Y 1 A LYS 15  ? CE  ? A LYS 49  CE  
4  1 Y 1 A LYS 15  ? NZ  ? A LYS 49  NZ  
5  1 Y 1 A ASP 36  ? OD1 ? A ASP 70  OD1 
6  1 Y 1 A ARG 56  ? CZ  ? A ARG 90  CZ  
7  1 Y 1 A ARG 56  ? NH1 ? A ARG 90  NH1 
8  1 Y 1 A ARG 56  ? NH2 ? A ARG 90  NH2 
9  1 Y 1 A LYS 59  ? CG  ? A LYS 93  CG  
10 1 Y 1 A LYS 59  ? CD  ? A LYS 93  CD  
11 1 Y 1 A LYS 59  ? CE  ? A LYS 93  CE  
12 1 Y 1 A LYS 59  ? NZ  ? A LYS 93  NZ  
13 1 Y 1 A LYS 94  ? CG  ? A LYS 128 CG  
14 1 Y 1 A LYS 94  ? CD  ? A LYS 128 CD  
15 1 Y 1 A LYS 94  ? CE  ? A LYS 128 CE  
16 1 Y 1 A LYS 94  ? NZ  ? A LYS 128 NZ  
17 1 Y 1 A ILE 157 ? CD1 ? A ILE 191 CD1 
18 1 Y 1 A ARG 205 ? CG  ? A ARG 239 CG  
19 1 Y 1 A ARG 205 ? CD  ? A ARG 239 CD  
20 1 Y 1 A ARG 205 ? NE  ? A ARG 239 NE  
21 1 Y 1 A ARG 205 ? CZ  ? A ARG 239 CZ  
22 1 Y 1 A ARG 205 ? NH1 ? A ARG 239 NH1 
23 1 Y 1 A ARG 205 ? NH2 ? A ARG 239 NH2 
24 1 Y 1 A GLN 273 ? CG  ? A GLN 307 CG  
25 1 Y 1 A GLN 273 ? CD  ? A GLN 307 CD  
26 1 Y 1 A GLN 273 ? OE1 ? A GLN 307 OE1 
27 1 Y 1 A GLN 273 ? NE2 ? A GLN 307 NE2 
28 1 Y 1 A ARG 307 ? CD  ? A ARG 341 CD  
29 1 Y 1 A ARG 307 ? NE  ? A ARG 341 NE  
30 1 Y 1 A ARG 307 ? CZ  ? A ARG 341 CZ  
31 1 Y 1 A ARG 307 ? NH1 ? A ARG 341 NH1 
32 1 Y 1 A ARG 307 ? NH2 ? A ARG 341 NH2 
33 1 Y 1 A ASP 309 ? OD1 ? A ASP 343 OD1 
34 1 Y 1 A ASP 309 ? OD2 ? A ASP 343 OD2 
35 1 Y 1 A LYS 353 ? CE  ? A LYS 387 CE  
36 1 Y 1 A LYS 353 ? NZ  ? A LYS 387 NZ  
37 1 Y 1 A LYS 360 ? CE  ? A LYS 394 CE  
38 1 Y 1 A LYS 360 ? NZ  ? A LYS 394 NZ  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? '(1.20.1_4487: ???)' 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .                    2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .                    3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .                    4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9JOM 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     83.135 
_cell.length_a_esd                 ? 
_cell.length_b                     83.135 
_cell.length_b_esd                 ? 
_cell.length_c                     100.430 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        6 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9JOM 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                154 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 32 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9JOM 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.20 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          44.05 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M HEPES pH 7.5, 20% w/v Polyethylene glycol 10,000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            290 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS3 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-06-23 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97923 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL19U1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97923 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL19U1 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9JOM 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.04 
_reflns.d_resolution_low                               72.00 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     26154 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.9 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                7.6 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          7.4 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               1.00 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.246 
_reflns.pdbx_Rpim_I_all                                0.084 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       199432 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.989 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.230 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.04 
_reflns_shell.d_res_low                                     2.15 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           17782 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             3769 
_reflns_shell.percent_possible_obs                          100.0 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               4.7 
_reflns_shell.pdbx_chi_squared                              1.01 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     2.3 
_reflns_shell.pdbx_Rrim_I_all                               0.842 
_reflns_shell.pdbx_Rpim_I_all                               0.385 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.730 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.745 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9JOM 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.04 
_refine.ls_d_res_low                             72.00 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     26118 
_refine.ls_number_reflns_R_free                  2014 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.90 
_refine.ls_percent_reflns_R_free                 7.71 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1813 
_refine.ls_R_factor_R_free                       0.2339 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1769 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.10 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 23.38 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.23 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.04 
_refine_hist.d_res_low                        72.00 
_refine_hist.number_atoms_solvent             391 
_refine_hist.number_atoms_total               3278 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2887 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.002 ? 2986 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.536 ? 4043 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 5.462 ? 382  ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.041 ? 410  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.003 ? 518  ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.04 2.09  . . 142 1689 100.00 . . . . 0.2390 . . . . . . . . . . . 0.3202 
'X-RAY DIFFRACTION' 2.09 2.15  . . 142 1683 100.00 . . . . 0.2197 . . . . . . . . . . . 0.2346 
'X-RAY DIFFRACTION' 2.15 2.21  . . 140 1716 100.00 . . . . 0.2126 . . . . . . . . . . . 0.2615 
'X-RAY DIFFRACTION' 2.21 2.28  . . 145 1703 100.00 . . . . 0.2052 . . . . . . . . . . . 0.3012 
'X-RAY DIFFRACTION' 2.28 2.36  . . 142 1695 100.00 . . . . 0.2102 . . . . . . . . . . . 0.2652 
'X-RAY DIFFRACTION' 2.36 2.46  . . 140 1698 100.00 . . . . 0.1993 . . . . . . . . . . . 0.2639 
'X-RAY DIFFRACTION' 2.46 2.57  . . 142 1696 100.00 . . . . 0.2085 . . . . . . . . . . . 0.2671 
'X-RAY DIFFRACTION' 2.57 2.70  . . 143 1723 100.00 . . . . 0.1901 . . . . . . . . . . . 0.2486 
'X-RAY DIFFRACTION' 2.70 2.87  . . 146 1726 100.00 . . . . 0.1874 . . . . . . . . . . . 0.2295 
'X-RAY DIFFRACTION' 2.87 3.09  . . 141 1722 100.00 . . . . 0.1769 . . . . . . . . . . . 0.2406 
'X-RAY DIFFRACTION' 3.09 3.41  . . 146 1709 100.00 . . . . 0.1712 . . . . . . . . . . . 0.2221 
'X-RAY DIFFRACTION' 3.41 3.90  . . 148 1748 100.00 . . . . 0.1449 . . . . . . . . . . . 0.2396 
'X-RAY DIFFRACTION' 3.90 4.90  . . 144 1754 100.00 . . . . 0.1311 . . . . . . . . . . . 0.1729 
'X-RAY DIFFRACTION' 4.92 72.00 . . 153 1842 100.00 . . . . 0.1742 . . . . . . . . . . . 0.2072 
# 
_struct.entry_id                     9JOM 
_struct.title                        'STRUCTURE OF ENDO-1,3-FUCANASE FUN168E FROM GH168 FAMILY' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9JOM 
_struct_keywords.text            'Endo-1.3-fucanase, GH168, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A0A1B1Y6K9_9FLAO 
_struct_ref.pdbx_db_accession          A0A1B1Y6K9 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;QSKTNKDYYPEFSWKTVPVAFHFAKRNGLMTDKELDFVTSHSNFIVLEKGHGGDIRTEKGIDNEAQRIKDINPKAKVVFY
WNAFLDYNLYDAHKEYENHKEWWLKKLDGNYDYKSAKVKRYDLSNPAFRKWWVSIAKKAVVDGHADGVFMDAFIQVINKG
NIELWGQKKYDAIQQGLKDLIAETRAAIGEDHLIVYNGIRSIPNRNVGNDFPEHTDAVMIEHFANFQSKSKESMLQDILE
MEKAGKTGKIVVFKAWPNEHSWIDKNFMAKPLQEKRKIARANITFPLAAFLAGAQENSYFIYNWGYRMDDGGLEWYPELD
KSLGKPLNEMKVHNWELTRNYEHASVWLNLATKEAKINWK
;
_struct_ref.pdbx_align_begin           30 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9JOM 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 35 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 394 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             A0A1B1Y6K9 
_struct_ref_seq.db_align_beg                  30 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  389 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       360 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9JOM MET A 1  ? UNP A0A1B1Y6K9 ? ? 'initiating methionine' -33 1  
1 9JOM GLY A 2  ? UNP A0A1B1Y6K9 ? ? 'expression tag'        -32 2  
1 9JOM SER A 3  ? UNP A0A1B1Y6K9 ? ? 'expression tag'        -31 3  
1 9JOM SER A 4  ? UNP A0A1B1Y6K9 ? ? 'expression tag'        -30 4  
1 9JOM HIS A 5  ? UNP A0A1B1Y6K9 ? ? 'expression tag'        -29 5  
1 9JOM HIS A 6  ? UNP A0A1B1Y6K9 ? ? 'expression tag'        -28 6  
1 9JOM HIS A 7  ? UNP A0A1B1Y6K9 ? ? 'expression tag'        -27 7  
1 9JOM HIS A 8  ? UNP A0A1B1Y6K9 ? ? 'expression tag'        -26 8  
1 9JOM HIS A 9  ? UNP A0A1B1Y6K9 ? ? 'expression tag'        -25 9  
1 9JOM HIS A 10 ? UNP A0A1B1Y6K9 ? ? 'expression tag'        -24 10 
1 9JOM SER A 11 ? UNP A0A1B1Y6K9 ? ? 'expression tag'        -23 11 
1 9JOM SER A 12 ? UNP A0A1B1Y6K9 ? ? 'expression tag'        -22 12 
1 9JOM GLY A 13 ? UNP A0A1B1Y6K9 ? ? 'expression tag'        -21 13 
1 9JOM LEU A 14 ? UNP A0A1B1Y6K9 ? ? 'expression tag'        -20 14 
1 9JOM VAL A 15 ? UNP A0A1B1Y6K9 ? ? 'expression tag'        -19 15 
1 9JOM PRO A 16 ? UNP A0A1B1Y6K9 ? ? 'expression tag'        -18 16 
1 9JOM ARG A 17 ? UNP A0A1B1Y6K9 ? ? 'expression tag'        -17 17 
1 9JOM GLY A 18 ? UNP A0A1B1Y6K9 ? ? 'expression tag'        -16 18 
1 9JOM SER A 19 ? UNP A0A1B1Y6K9 ? ? 'expression tag'        -15 19 
1 9JOM HIS A 20 ? UNP A0A1B1Y6K9 ? ? 'expression tag'        -14 20 
1 9JOM MET A 21 ? UNP A0A1B1Y6K9 ? ? 'expression tag'        -13 21 
1 9JOM ALA A 22 ? UNP A0A1B1Y6K9 ? ? 'expression tag'        -12 22 
1 9JOM SER A 23 ? UNP A0A1B1Y6K9 ? ? 'expression tag'        -11 23 
1 9JOM MET A 24 ? UNP A0A1B1Y6K9 ? ? 'expression tag'        -10 24 
1 9JOM THR A 25 ? UNP A0A1B1Y6K9 ? ? 'expression tag'        -9  25 
1 9JOM GLY A 26 ? UNP A0A1B1Y6K9 ? ? 'expression tag'        -8  26 
1 9JOM GLY A 27 ? UNP A0A1B1Y6K9 ? ? 'expression tag'        -7  27 
1 9JOM GLN A 28 ? UNP A0A1B1Y6K9 ? ? 'expression tag'        -6  28 
1 9JOM GLN A 29 ? UNP A0A1B1Y6K9 ? ? 'expression tag'        -5  29 
1 9JOM MET A 30 ? UNP A0A1B1Y6K9 ? ? 'expression tag'        -4  30 
1 9JOM GLY A 31 ? UNP A0A1B1Y6K9 ? ? 'expression tag'        -3  31 
1 9JOM ARG A 32 ? UNP A0A1B1Y6K9 ? ? 'expression tag'        -2  32 
1 9JOM GLY A 33 ? UNP A0A1B1Y6K9 ? ? 'expression tag'        -1  33 
1 9JOM SER A 34 ? UNP A0A1B1Y6K9 ? ? 'expression tag'        0   34 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 THR A 65  ? SER A 76  ? THR A 31  SER A 42  1 ? 12 
HELX_P HELX_P2  AA2 GLY A 86  ? ASP A 88  ? GLY A 52  ASP A 54  5 ? 3  
HELX_P HELX_P3  AA3 ILE A 89  ? ASN A 106 ? ILE A 55  ASN A 72  1 ? 18 
HELX_P HELX_P4  AA4 TYR A 124 ? ASN A 132 ? TYR A 90  ASN A 98  1 ? 9  
HELX_P HELX_P5  AA5 HIS A 133 ? TRP A 137 ? HIS A 99  TRP A 103 5 ? 5  
HELX_P HELX_P6  AA6 ASN A 159 ? VAL A 175 ? ASN A 125 VAL A 141 1 ? 17 
HELX_P HELX_P7  AA7 ALA A 186 ? ASN A 192 ? ALA A 152 ASN A 158 1 ? 7  
HELX_P HELX_P8  AA8 LYS A 193 ? GLY A 200 ? LYS A 159 GLY A 166 1 ? 8  
HELX_P HELX_P9  AA9 GLY A 200 ? GLY A 223 ? GLY A 166 GLY A 189 1 ? 24 
HELX_P HELX_P10 AB1 SER A 264 ? THR A 281 ? SER A 230 THR A 247 1 ? 18 
HELX_P HELX_P11 AB2 ASP A 298 ? ALA A 303 ? ASP A 264 ALA A 269 1 ? 6  
HELX_P HELX_P12 AB3 PRO A 305 ? ASN A 316 ? PRO A 271 ASN A 282 1 ? 12 
HELX_P HELX_P13 AB4 ILE A 317 ? ALA A 328 ? ILE A 283 ALA A 294 1 ? 12 
HELX_P HELX_P14 AB5 TYR A 350 ? LYS A 355 ? TYR A 316 LYS A 321 5 ? 6  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 8 ? 
AA2 ? 3 ? 
AA3 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? parallel      
AA1 3 4 ? parallel      
AA1 4 5 ? parallel      
AA1 5 6 ? parallel      
AA1 6 7 ? parallel      
AA1 7 8 ? parallel      
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE A 55  ? PHE A 57  ? PHE A 21  PHE A 23  
AA1 2 PHE A 78  ? LEU A 81  ? PHE A 44  LEU A 47  
AA1 3 LYS A 110 ? ASN A 116 ? LYS A 76  ASN A 82  
AA1 4 GLY A 181 ? ASP A 185 ? GLY A 147 ASP A 151 
AA1 5 LEU A 227 ? ILE A 233 ? LEU A 193 ILE A 199 
AA1 6 ALA A 251 ? ILE A 254 ? ALA A 217 ILE A 220 
AA1 7 ILE A 284 ? ALA A 289 ? ILE A 250 ALA A 255 
AA1 8 SER A 332 ? TYR A 336 ? SER A 298 TYR A 302 
AA2 1 LEU A 119 ? ASP A 120 ? LEU A 85  ASP A 86  
AA2 2 VAL A 152 ? ARG A 154 ? VAL A 118 ARG A 120 
AA2 3 TYR A 147 ? SER A 149 ? TYR A 113 SER A 115 
AA3 1 LYS A 365 ? HIS A 367 ? LYS A 331 HIS A 333 
AA3 2 GLU A 370 ? TYR A 375 ? GLU A 336 TYR A 341 
AA3 3 ALA A 378 ? ASN A 383 ? ALA A 344 ASN A 349 
AA3 4 GLU A 388 ? TRP A 393 ? GLU A 354 TRP A 359 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N PHE A 55  ? N PHE A 21  O VAL A 80  ? O VAL A 46  
AA1 2 3 N ILE A 79  ? N ILE A 45  O LYS A 110 ? O LYS A 76  
AA1 3 4 N PHE A 113 ? N PHE A 79  O GLY A 181 ? O GLY A 147 
AA1 4 5 N MET A 184 ? N MET A 150 O VAL A 229 ? O VAL A 195 
AA1 5 6 N TYR A 230 ? N TYR A 196 O ALA A 251 ? O ALA A 217 
AA1 6 7 N ILE A 254 ? N ILE A 220 O VAL A 286 ? O VAL A 252 
AA1 7 8 N PHE A 287 ? N PHE A 253 O TYR A 333 ? O TYR A 299 
AA2 1 2 N ASP A 120 ? N ASP A 86  O LYS A 153 ? O LYS A 119 
AA2 2 3 O VAL A 152 ? O VAL A 118 N LYS A 148 ? N LYS A 114 
AA3 1 2 N HIS A 367 ? N HIS A 333 O GLU A 370 ? O GLU A 336 
AA3 2 3 N TYR A 375 ? N TYR A 341 O ALA A 378 ? O ALA A 344 
AA3 3 4 N TRP A 381 ? N TRP A 347 O LYS A 390 ? O LYS A 356 
# 
_pdbx_entry_details.entry_id                   9JOM 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 O A HOH 626 ? ? O A HOH 729 ? ? 2.07 
2 1 O A HOH 750 ? ? O A HOH 758 ? ? 2.11 
3 1 O A HOH 450 ? ? O A HOH 471 ? ? 2.13 
4 1 O A HOH 529 ? ? O A HOH 603 ? ? 2.16 
5 1 O A HOH 722 ? ? O A HOH 777 ? ? 2.16 
6 1 O A HOH 564 ? ? O A HOH 640 ? ? 2.19 
# 
loop_
_pdbx_validate_symm_contact.id 
_pdbx_validate_symm_contact.PDB_model_num 
_pdbx_validate_symm_contact.auth_atom_id_1 
_pdbx_validate_symm_contact.auth_asym_id_1 
_pdbx_validate_symm_contact.auth_comp_id_1 
_pdbx_validate_symm_contact.auth_seq_id_1 
_pdbx_validate_symm_contact.PDB_ins_code_1 
_pdbx_validate_symm_contact.label_alt_id_1 
_pdbx_validate_symm_contact.site_symmetry_1 
_pdbx_validate_symm_contact.auth_atom_id_2 
_pdbx_validate_symm_contact.auth_asym_id_2 
_pdbx_validate_symm_contact.auth_comp_id_2 
_pdbx_validate_symm_contact.auth_seq_id_2 
_pdbx_validate_symm_contact.PDB_ins_code_2 
_pdbx_validate_symm_contact.label_alt_id_2 
_pdbx_validate_symm_contact.site_symmetry_2 
_pdbx_validate_symm_contact.dist 
1 1 O A HOH 421 ? ? 1_555 O A HOH 710 ? ? 4_465 2.09 
2 1 O A HOH 670 ? ? 1_555 O A HOH 740 ? ? 4_565 2.13 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ARG A 56  ? ? 74.44   168.53  
2 1 ALA A 152 ? ? 85.64   15.59   
3 1 ARG A 205 ? ? -143.57 36.79   
4 1 PHE A 226 ? ? 58.71   -125.87 
5 1 ASN A 303 ? ? -171.70 -174.74 
6 1 ASP A 310 ? ? -79.34  47.93   
7 1 LEU A 323 ? ? -107.76 -62.40  
8 1 ASN A 334 ? ? 58.63   -121.11 
# 
_pdbx_struct_special_symmetry.id              1 
_pdbx_struct_special_symmetry.PDB_model_num   1 
_pdbx_struct_special_symmetry.auth_asym_id    A 
_pdbx_struct_special_symmetry.auth_comp_id    HOH 
_pdbx_struct_special_symmetry.auth_seq_id     542 
_pdbx_struct_special_symmetry.PDB_ins_code    ? 
_pdbx_struct_special_symmetry.label_asym_id   B 
_pdbx_struct_special_symmetry.label_comp_id   HOH 
_pdbx_struct_special_symmetry.label_seq_id    . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET -33 ? A MET 1  
2  1 Y 1 A GLY -32 ? A GLY 2  
3  1 Y 1 A SER -31 ? A SER 3  
4  1 Y 1 A SER -30 ? A SER 4  
5  1 Y 1 A HIS -29 ? A HIS 5  
6  1 Y 1 A HIS -28 ? A HIS 6  
7  1 Y 1 A HIS -27 ? A HIS 7  
8  1 Y 1 A HIS -26 ? A HIS 8  
9  1 Y 1 A HIS -25 ? A HIS 9  
10 1 Y 1 A HIS -24 ? A HIS 10 
11 1 Y 1 A SER -23 ? A SER 11 
12 1 Y 1 A SER -22 ? A SER 12 
13 1 Y 1 A GLY -21 ? A GLY 13 
14 1 Y 1 A LEU -20 ? A LEU 14 
15 1 Y 1 A VAL -19 ? A VAL 15 
16 1 Y 1 A PRO -18 ? A PRO 16 
17 1 Y 1 A ARG -17 ? A ARG 17 
18 1 Y 1 A GLY -16 ? A GLY 18 
19 1 Y 1 A SER -15 ? A SER 19 
20 1 Y 1 A HIS -14 ? A HIS 20 
21 1 Y 1 A MET -13 ? A MET 21 
22 1 Y 1 A ALA -12 ? A ALA 22 
23 1 Y 1 A SER -11 ? A SER 23 
24 1 Y 1 A MET -10 ? A MET 24 
25 1 Y 1 A THR -9  ? A THR 25 
26 1 Y 1 A GLY -8  ? A GLY 26 
27 1 Y 1 A GLY -7  ? A GLY 27 
28 1 Y 1 A GLN -6  ? A GLN 28 
29 1 Y 1 A GLN -5  ? A GLN 29 
30 1 Y 1 A MET -4  ? A MET 30 
31 1 Y 1 A GLY -3  ? A GLY 31 
32 1 Y 1 A ARG -2  ? A ARG 32 
33 1 Y 1 A GLY -1  ? A GLY 33 
34 1 Y 1 A SER 0   ? A SER 34 
35 1 Y 1 A GLN 1   ? A GLN 35 
36 1 Y 1 A SER 2   ? A SER 36 
37 1 Y 1 A LYS 3   ? A LYS 37 
38 1 Y 1 A THR 4   ? A THR 38 
39 1 Y 1 A ASN 5   ? A ASN 39 
40 1 Y 1 A LYS 6   ? A LYS 40 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
GLN N    N N N 74  
GLN CA   C N S 75  
GLN C    C N N 76  
GLN O    O N N 77  
GLN CB   C N N 78  
GLN CG   C N N 79  
GLN CD   C N N 80  
GLN OE1  O N N 81  
GLN NE2  N N N 82  
GLN OXT  O N N 83  
GLN H    H N N 84  
GLN H2   H N N 85  
GLN HA   H N N 86  
GLN HB2  H N N 87  
GLN HB3  H N N 88  
GLN HG2  H N N 89  
GLN HG3  H N N 90  
GLN HE21 H N N 91  
GLN HE22 H N N 92  
GLN HXT  H N N 93  
GLU N    N N N 94  
GLU CA   C N S 95  
GLU C    C N N 96  
GLU O    O N N 97  
GLU CB   C N N 98  
GLU CG   C N N 99  
GLU CD   C N N 100 
GLU OE1  O N N 101 
GLU OE2  O N N 102 
GLU OXT  O N N 103 
GLU H    H N N 104 
GLU H2   H N N 105 
GLU HA   H N N 106 
GLU HB2  H N N 107 
GLU HB3  H N N 108 
GLU HG2  H N N 109 
GLU HG3  H N N 110 
GLU HE2  H N N 111 
GLU HXT  H N N 112 
GLY N    N N N 113 
GLY CA   C N N 114 
GLY C    C N N 115 
GLY O    O N N 116 
GLY OXT  O N N 117 
GLY H    H N N 118 
GLY H2   H N N 119 
GLY HA2  H N N 120 
GLY HA3  H N N 121 
GLY HXT  H N N 122 
HIS N    N N N 123 
HIS CA   C N S 124 
HIS C    C N N 125 
HIS O    O N N 126 
HIS CB   C N N 127 
HIS CG   C Y N 128 
HIS ND1  N Y N 129 
HIS CD2  C Y N 130 
HIS CE1  C Y N 131 
HIS NE2  N Y N 132 
HIS OXT  O N N 133 
HIS H    H N N 134 
HIS H2   H N N 135 
HIS HA   H N N 136 
HIS HB2  H N N 137 
HIS HB3  H N N 138 
HIS HD1  H N N 139 
HIS HD2  H N N 140 
HIS HE1  H N N 141 
HIS HE2  H N N 142 
HIS HXT  H N N 143 
HOH O    O N N 144 
HOH H1   H N N 145 
HOH H2   H N N 146 
ILE N    N N N 147 
ILE CA   C N S 148 
ILE C    C N N 149 
ILE O    O N N 150 
ILE CB   C N S 151 
ILE CG1  C N N 152 
ILE CG2  C N N 153 
ILE CD1  C N N 154 
ILE OXT  O N N 155 
ILE H    H N N 156 
ILE H2   H N N 157 
ILE HA   H N N 158 
ILE HB   H N N 159 
ILE HG12 H N N 160 
ILE HG13 H N N 161 
ILE HG21 H N N 162 
ILE HG22 H N N 163 
ILE HG23 H N N 164 
ILE HD11 H N N 165 
ILE HD12 H N N 166 
ILE HD13 H N N 167 
ILE HXT  H N N 168 
LEU N    N N N 169 
LEU CA   C N S 170 
LEU C    C N N 171 
LEU O    O N N 172 
LEU CB   C N N 173 
LEU CG   C N N 174 
LEU CD1  C N N 175 
LEU CD2  C N N 176 
LEU OXT  O N N 177 
LEU H    H N N 178 
LEU H2   H N N 179 
LEU HA   H N N 180 
LEU HB2  H N N 181 
LEU HB3  H N N 182 
LEU HG   H N N 183 
LEU HD11 H N N 184 
LEU HD12 H N N 185 
LEU HD13 H N N 186 
LEU HD21 H N N 187 
LEU HD22 H N N 188 
LEU HD23 H N N 189 
LEU HXT  H N N 190 
LYS N    N N N 191 
LYS CA   C N S 192 
LYS C    C N N 193 
LYS O    O N N 194 
LYS CB   C N N 195 
LYS CG   C N N 196 
LYS CD   C N N 197 
LYS CE   C N N 198 
LYS NZ   N N N 199 
LYS OXT  O N N 200 
LYS H    H N N 201 
LYS H2   H N N 202 
LYS HA   H N N 203 
LYS HB2  H N N 204 
LYS HB3  H N N 205 
LYS HG2  H N N 206 
LYS HG3  H N N 207 
LYS HD2  H N N 208 
LYS HD3  H N N 209 
LYS HE2  H N N 210 
LYS HE3  H N N 211 
LYS HZ1  H N N 212 
LYS HZ2  H N N 213 
LYS HZ3  H N N 214 
LYS HXT  H N N 215 
MET N    N N N 216 
MET CA   C N S 217 
MET C    C N N 218 
MET O    O N N 219 
MET CB   C N N 220 
MET CG   C N N 221 
MET SD   S N N 222 
MET CE   C N N 223 
MET OXT  O N N 224 
MET H    H N N 225 
MET H2   H N N 226 
MET HA   H N N 227 
MET HB2  H N N 228 
MET HB3  H N N 229 
MET HG2  H N N 230 
MET HG3  H N N 231 
MET HE1  H N N 232 
MET HE2  H N N 233 
MET HE3  H N N 234 
MET HXT  H N N 235 
PHE N    N N N 236 
PHE CA   C N S 237 
PHE C    C N N 238 
PHE O    O N N 239 
PHE CB   C N N 240 
PHE CG   C Y N 241 
PHE CD1  C Y N 242 
PHE CD2  C Y N 243 
PHE CE1  C Y N 244 
PHE CE2  C Y N 245 
PHE CZ   C Y N 246 
PHE OXT  O N N 247 
PHE H    H N N 248 
PHE H2   H N N 249 
PHE HA   H N N 250 
PHE HB2  H N N 251 
PHE HB3  H N N 252 
PHE HD1  H N N 253 
PHE HD2  H N N 254 
PHE HE1  H N N 255 
PHE HE2  H N N 256 
PHE HZ   H N N 257 
PHE HXT  H N N 258 
PRO N    N N N 259 
PRO CA   C N S 260 
PRO C    C N N 261 
PRO O    O N N 262 
PRO CB   C N N 263 
PRO CG   C N N 264 
PRO CD   C N N 265 
PRO OXT  O N N 266 
PRO H    H N N 267 
PRO HA   H N N 268 
PRO HB2  H N N 269 
PRO HB3  H N N 270 
PRO HG2  H N N 271 
PRO HG3  H N N 272 
PRO HD2  H N N 273 
PRO HD3  H N N 274 
PRO HXT  H N N 275 
SER N    N N N 276 
SER CA   C N S 277 
SER C    C N N 278 
SER O    O N N 279 
SER CB   C N N 280 
SER OG   O N N 281 
SER OXT  O N N 282 
SER H    H N N 283 
SER H2   H N N 284 
SER HA   H N N 285 
SER HB2  H N N 286 
SER HB3  H N N 287 
SER HG   H N N 288 
SER HXT  H N N 289 
THR N    N N N 290 
THR CA   C N S 291 
THR C    C N N 292 
THR O    O N N 293 
THR CB   C N R 294 
THR OG1  O N N 295 
THR CG2  C N N 296 
THR OXT  O N N 297 
THR H    H N N 298 
THR H2   H N N 299 
THR HA   H N N 300 
THR HB   H N N 301 
THR HG1  H N N 302 
THR HG21 H N N 303 
THR HG22 H N N 304 
THR HG23 H N N 305 
THR HXT  H N N 306 
TRP N    N N N 307 
TRP CA   C N S 308 
TRP C    C N N 309 
TRP O    O N N 310 
TRP CB   C N N 311 
TRP CG   C Y N 312 
TRP CD1  C Y N 313 
TRP CD2  C Y N 314 
TRP NE1  N Y N 315 
TRP CE2  C Y N 316 
TRP CE3  C Y N 317 
TRP CZ2  C Y N 318 
TRP CZ3  C Y N 319 
TRP CH2  C Y N 320 
TRP OXT  O N N 321 
TRP H    H N N 322 
TRP H2   H N N 323 
TRP HA   H N N 324 
TRP HB2  H N N 325 
TRP HB3  H N N 326 
TRP HD1  H N N 327 
TRP HE1  H N N 328 
TRP HE3  H N N 329 
TRP HZ2  H N N 330 
TRP HZ3  H N N 331 
TRP HH2  H N N 332 
TRP HXT  H N N 333 
TYR N    N N N 334 
TYR CA   C N S 335 
TYR C    C N N 336 
TYR O    O N N 337 
TYR CB   C N N 338 
TYR CG   C Y N 339 
TYR CD1  C Y N 340 
TYR CD2  C Y N 341 
TYR CE1  C Y N 342 
TYR CE2  C Y N 343 
TYR CZ   C Y N 344 
TYR OH   O N N 345 
TYR OXT  O N N 346 
TYR H    H N N 347 
TYR H2   H N N 348 
TYR HA   H N N 349 
TYR HB2  H N N 350 
TYR HB3  H N N 351 
TYR HD1  H N N 352 
TYR HD2  H N N 353 
TYR HE1  H N N 354 
TYR HE2  H N N 355 
TYR HH   H N N 356 
TYR HXT  H N N 357 
VAL N    N N N 358 
VAL CA   C N S 359 
VAL C    C N N 360 
VAL O    O N N 361 
VAL CB   C N N 362 
VAL CG1  C N N 363 
VAL CG2  C N N 364 
VAL OXT  O N N 365 
VAL H    H N N 366 
VAL H2   H N N 367 
VAL HA   H N N 368 
VAL HB   H N N 369 
VAL HG11 H N N 370 
VAL HG12 H N N 371 
VAL HG13 H N N 372 
VAL HG21 H N N 373 
VAL HG22 H N N 374 
VAL HG23 H N N 375 
VAL HXT  H N N 376 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
GLN N   CA   sing N N 70  
GLN N   H    sing N N 71  
GLN N   H2   sing N N 72  
GLN CA  C    sing N N 73  
GLN CA  CB   sing N N 74  
GLN CA  HA   sing N N 75  
GLN C   O    doub N N 76  
GLN C   OXT  sing N N 77  
GLN CB  CG   sing N N 78  
GLN CB  HB2  sing N N 79  
GLN CB  HB3  sing N N 80  
GLN CG  CD   sing N N 81  
GLN CG  HG2  sing N N 82  
GLN CG  HG3  sing N N 83  
GLN CD  OE1  doub N N 84  
GLN CD  NE2  sing N N 85  
GLN NE2 HE21 sing N N 86  
GLN NE2 HE22 sing N N 87  
GLN OXT HXT  sing N N 88  
GLU N   CA   sing N N 89  
GLU N   H    sing N N 90  
GLU N   H2   sing N N 91  
GLU CA  C    sing N N 92  
GLU CA  CB   sing N N 93  
GLU CA  HA   sing N N 94  
GLU C   O    doub N N 95  
GLU C   OXT  sing N N 96  
GLU CB  CG   sing N N 97  
GLU CB  HB2  sing N N 98  
GLU CB  HB3  sing N N 99  
GLU CG  CD   sing N N 100 
GLU CG  HG2  sing N N 101 
GLU CG  HG3  sing N N 102 
GLU CD  OE1  doub N N 103 
GLU CD  OE2  sing N N 104 
GLU OE2 HE2  sing N N 105 
GLU OXT HXT  sing N N 106 
GLY N   CA   sing N N 107 
GLY N   H    sing N N 108 
GLY N   H2   sing N N 109 
GLY CA  C    sing N N 110 
GLY CA  HA2  sing N N 111 
GLY CA  HA3  sing N N 112 
GLY C   O    doub N N 113 
GLY C   OXT  sing N N 114 
GLY OXT HXT  sing N N 115 
HIS N   CA   sing N N 116 
HIS N   H    sing N N 117 
HIS N   H2   sing N N 118 
HIS CA  C    sing N N 119 
HIS CA  CB   sing N N 120 
HIS CA  HA   sing N N 121 
HIS C   O    doub N N 122 
HIS C   OXT  sing N N 123 
HIS CB  CG   sing N N 124 
HIS CB  HB2  sing N N 125 
HIS CB  HB3  sing N N 126 
HIS CG  ND1  sing Y N 127 
HIS CG  CD2  doub Y N 128 
HIS ND1 CE1  doub Y N 129 
HIS ND1 HD1  sing N N 130 
HIS CD2 NE2  sing Y N 131 
HIS CD2 HD2  sing N N 132 
HIS CE1 NE2  sing Y N 133 
HIS CE1 HE1  sing N N 134 
HIS NE2 HE2  sing N N 135 
HIS OXT HXT  sing N N 136 
HOH O   H1   sing N N 137 
HOH O   H2   sing N N 138 
ILE N   CA   sing N N 139 
ILE N   H    sing N N 140 
ILE N   H2   sing N N 141 
ILE CA  C    sing N N 142 
ILE CA  CB   sing N N 143 
ILE CA  HA   sing N N 144 
ILE C   O    doub N N 145 
ILE C   OXT  sing N N 146 
ILE CB  CG1  sing N N 147 
ILE CB  CG2  sing N N 148 
ILE CB  HB   sing N N 149 
ILE CG1 CD1  sing N N 150 
ILE CG1 HG12 sing N N 151 
ILE CG1 HG13 sing N N 152 
ILE CG2 HG21 sing N N 153 
ILE CG2 HG22 sing N N 154 
ILE CG2 HG23 sing N N 155 
ILE CD1 HD11 sing N N 156 
ILE CD1 HD12 sing N N 157 
ILE CD1 HD13 sing N N 158 
ILE OXT HXT  sing N N 159 
LEU N   CA   sing N N 160 
LEU N   H    sing N N 161 
LEU N   H2   sing N N 162 
LEU CA  C    sing N N 163 
LEU CA  CB   sing N N 164 
LEU CA  HA   sing N N 165 
LEU C   O    doub N N 166 
LEU C   OXT  sing N N 167 
LEU CB  CG   sing N N 168 
LEU CB  HB2  sing N N 169 
LEU CB  HB3  sing N N 170 
LEU CG  CD1  sing N N 171 
LEU CG  CD2  sing N N 172 
LEU CG  HG   sing N N 173 
LEU CD1 HD11 sing N N 174 
LEU CD1 HD12 sing N N 175 
LEU CD1 HD13 sing N N 176 
LEU CD2 HD21 sing N N 177 
LEU CD2 HD22 sing N N 178 
LEU CD2 HD23 sing N N 179 
LEU OXT HXT  sing N N 180 
LYS N   CA   sing N N 181 
LYS N   H    sing N N 182 
LYS N   H2   sing N N 183 
LYS CA  C    sing N N 184 
LYS CA  CB   sing N N 185 
LYS CA  HA   sing N N 186 
LYS C   O    doub N N 187 
LYS C   OXT  sing N N 188 
LYS CB  CG   sing N N 189 
LYS CB  HB2  sing N N 190 
LYS CB  HB3  sing N N 191 
LYS CG  CD   sing N N 192 
LYS CG  HG2  sing N N 193 
LYS CG  HG3  sing N N 194 
LYS CD  CE   sing N N 195 
LYS CD  HD2  sing N N 196 
LYS CD  HD3  sing N N 197 
LYS CE  NZ   sing N N 198 
LYS CE  HE2  sing N N 199 
LYS CE  HE3  sing N N 200 
LYS NZ  HZ1  sing N N 201 
LYS NZ  HZ2  sing N N 202 
LYS NZ  HZ3  sing N N 203 
LYS OXT HXT  sing N N 204 
MET N   CA   sing N N 205 
MET N   H    sing N N 206 
MET N   H2   sing N N 207 
MET CA  C    sing N N 208 
MET CA  CB   sing N N 209 
MET CA  HA   sing N N 210 
MET C   O    doub N N 211 
MET C   OXT  sing N N 212 
MET CB  CG   sing N N 213 
MET CB  HB2  sing N N 214 
MET CB  HB3  sing N N 215 
MET CG  SD   sing N N 216 
MET CG  HG2  sing N N 217 
MET CG  HG3  sing N N 218 
MET SD  CE   sing N N 219 
MET CE  HE1  sing N N 220 
MET CE  HE2  sing N N 221 
MET CE  HE3  sing N N 222 
MET OXT HXT  sing N N 223 
PHE N   CA   sing N N 224 
PHE N   H    sing N N 225 
PHE N   H2   sing N N 226 
PHE CA  C    sing N N 227 
PHE CA  CB   sing N N 228 
PHE CA  HA   sing N N 229 
PHE C   O    doub N N 230 
PHE C   OXT  sing N N 231 
PHE CB  CG   sing N N 232 
PHE CB  HB2  sing N N 233 
PHE CB  HB3  sing N N 234 
PHE CG  CD1  doub Y N 235 
PHE CG  CD2  sing Y N 236 
PHE CD1 CE1  sing Y N 237 
PHE CD1 HD1  sing N N 238 
PHE CD2 CE2  doub Y N 239 
PHE CD2 HD2  sing N N 240 
PHE CE1 CZ   doub Y N 241 
PHE CE1 HE1  sing N N 242 
PHE CE2 CZ   sing Y N 243 
PHE CE2 HE2  sing N N 244 
PHE CZ  HZ   sing N N 245 
PHE OXT HXT  sing N N 246 
PRO N   CA   sing N N 247 
PRO N   CD   sing N N 248 
PRO N   H    sing N N 249 
PRO CA  C    sing N N 250 
PRO CA  CB   sing N N 251 
PRO CA  HA   sing N N 252 
PRO C   O    doub N N 253 
PRO C   OXT  sing N N 254 
PRO CB  CG   sing N N 255 
PRO CB  HB2  sing N N 256 
PRO CB  HB3  sing N N 257 
PRO CG  CD   sing N N 258 
PRO CG  HG2  sing N N 259 
PRO CG  HG3  sing N N 260 
PRO CD  HD2  sing N N 261 
PRO CD  HD3  sing N N 262 
PRO OXT HXT  sing N N 263 
SER N   CA   sing N N 264 
SER N   H    sing N N 265 
SER N   H2   sing N N 266 
SER CA  C    sing N N 267 
SER CA  CB   sing N N 268 
SER CA  HA   sing N N 269 
SER C   O    doub N N 270 
SER C   OXT  sing N N 271 
SER CB  OG   sing N N 272 
SER CB  HB2  sing N N 273 
SER CB  HB3  sing N N 274 
SER OG  HG   sing N N 275 
SER OXT HXT  sing N N 276 
THR N   CA   sing N N 277 
THR N   H    sing N N 278 
THR N   H2   sing N N 279 
THR CA  C    sing N N 280 
THR CA  CB   sing N N 281 
THR CA  HA   sing N N 282 
THR C   O    doub N N 283 
THR C   OXT  sing N N 284 
THR CB  OG1  sing N N 285 
THR CB  CG2  sing N N 286 
THR CB  HB   sing N N 287 
THR OG1 HG1  sing N N 288 
THR CG2 HG21 sing N N 289 
THR CG2 HG22 sing N N 290 
THR CG2 HG23 sing N N 291 
THR OXT HXT  sing N N 292 
TRP N   CA   sing N N 293 
TRP N   H    sing N N 294 
TRP N   H2   sing N N 295 
TRP CA  C    sing N N 296 
TRP CA  CB   sing N N 297 
TRP CA  HA   sing N N 298 
TRP C   O    doub N N 299 
TRP C   OXT  sing N N 300 
TRP CB  CG   sing N N 301 
TRP CB  HB2  sing N N 302 
TRP CB  HB3  sing N N 303 
TRP CG  CD1  doub Y N 304 
TRP CG  CD2  sing Y N 305 
TRP CD1 NE1  sing Y N 306 
TRP CD1 HD1  sing N N 307 
TRP CD2 CE2  doub Y N 308 
TRP CD2 CE3  sing Y N 309 
TRP NE1 CE2  sing Y N 310 
TRP NE1 HE1  sing N N 311 
TRP CE2 CZ2  sing Y N 312 
TRP CE3 CZ3  doub Y N 313 
TRP CE3 HE3  sing N N 314 
TRP CZ2 CH2  doub Y N 315 
TRP CZ2 HZ2  sing N N 316 
TRP CZ3 CH2  sing Y N 317 
TRP CZ3 HZ3  sing N N 318 
TRP CH2 HH2  sing N N 319 
TRP OXT HXT  sing N N 320 
TYR N   CA   sing N N 321 
TYR N   H    sing N N 322 
TYR N   H2   sing N N 323 
TYR CA  C    sing N N 324 
TYR CA  CB   sing N N 325 
TYR CA  HA   sing N N 326 
TYR C   O    doub N N 327 
TYR C   OXT  sing N N 328 
TYR CB  CG   sing N N 329 
TYR CB  HB2  sing N N 330 
TYR CB  HB3  sing N N 331 
TYR CG  CD1  doub Y N 332 
TYR CG  CD2  sing Y N 333 
TYR CD1 CE1  sing Y N 334 
TYR CD1 HD1  sing N N 335 
TYR CD2 CE2  doub Y N 336 
TYR CD2 HD2  sing N N 337 
TYR CE1 CZ   doub Y N 338 
TYR CE1 HE1  sing N N 339 
TYR CE2 CZ   sing Y N 340 
TYR CE2 HE2  sing N N 341 
TYR CZ  OH   sing N N 342 
TYR OH  HH   sing N N 343 
TYR OXT HXT  sing N N 344 
VAL N   CA   sing N N 345 
VAL N   H    sing N N 346 
VAL N   H2   sing N N 347 
VAL CA  C    sing N N 348 
VAL CA  CB   sing N N 349 
VAL CA  HA   sing N N 350 
VAL C   O    doub N N 351 
VAL C   OXT  sing N N 352 
VAL CB  CG1  sing N N 353 
VAL CB  CG2  sing N N 354 
VAL CB  HB   sing N N 355 
VAL CG1 HG11 sing N N 356 
VAL CG1 HG12 sing N N 357 
VAL CG1 HG13 sing N N 358 
VAL CG2 HG21 sing N N 359 
VAL CG2 HG22 sing N N 360 
VAL CG2 HG23 sing N N 361 
VAL OXT HXT  sing N N 362 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           U22A20542 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'in silico model' 
_pdbx_initial_refinement_model.source_name      AlphaFold 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9JOM 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.012029 
_atom_sites.fract_transf_matrix[1][2]   0.006945 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.013889 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009957 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
H 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N    . ASP A 1 41  ? -51.009 35.418 -10.658 1.00 39.43 ? 7   ASP A N    1 
ATOM   2    C CA   . ASP A 1 41  ? -49.796 36.215 -10.506 1.00 40.83 ? 7   ASP A CA   1 
ATOM   3    C C    . ASP A 1 41  ? -48.727 35.447 -9.731  1.00 29.70 ? 7   ASP A C    1 
ATOM   4    O O    . ASP A 1 41  ? -49.028 34.695 -8.804  1.00 35.52 ? 7   ASP A O    1 
ATOM   5    C CB   . ASP A 1 41  ? -50.112 37.539 -9.805  1.00 41.12 ? 7   ASP A CB   1 
ATOM   6    C CG   . ASP A 1 41  ? -49.971 38.740 -10.726 1.00 47.96 ? 7   ASP A CG   1 
ATOM   7    O OD1  . ASP A 1 41  ? -50.002 38.562 -11.962 1.00 48.22 ? 7   ASP A OD1  1 
ATOM   8    O OD2  . ASP A 1 41  ? -49.827 39.868 -10.208 1.00 52.22 ? 7   ASP A OD2  1 
ATOM   9    H HA   . ASP A 1 41  ? -49.438 36.418 -11.385 1.00 49.03 ? 7   ASP A HA   1 
ATOM   10   H HB2  . ASP A 1 41  ? -51.027 37.515 -9.482  1.00 49.37 ? 7   ASP A HB2  1 
ATOM   11   H HB3  . ASP A 1 41  ? -49.501 37.657 -9.062  1.00 49.37 ? 7   ASP A HB3  1 
ATOM   12   N N    . TYR A 1 42  ? -47.471 35.657 -10.126 1.00 27.98 ? 8   TYR A N    1 
ATOM   13   C CA   . TYR A 1 42  ? -46.348 34.910 -9.567  1.00 22.47 ? 8   TYR A CA   1 
ATOM   14   C C    . TYR A 1 42  ? -45.944 35.453 -8.199  1.00 23.67 ? 8   TYR A C    1 
ATOM   15   O O    . TYR A 1 42  ? -46.055 34.759 -7.182  1.00 20.41 ? 8   TYR A O    1 
ATOM   16   C CB   . TYR A 1 42  ? -45.172 34.971 -10.548 1.00 28.52 ? 8   TYR A CB   1 
ATOM   17   C CG   . TYR A 1 42  ? -44.021 34.037 -10.251 1.00 21.73 ? 8   TYR A CG   1 
ATOM   18   C CD1  . TYR A 1 42  ? -44.209 32.664 -10.187 1.00 22.00 ? 8   TYR A CD1  1 
ATOM   19   C CD2  . TYR A 1 42  ? -42.736 34.530 -10.065 1.00 23.59 ? 8   TYR A CD2  1 
ATOM   20   C CE1  . TYR A 1 42  ? -43.153 31.811 -9.928  1.00 23.50 ? 8   TYR A CE1  1 
ATOM   21   C CE2  . TYR A 1 42  ? -41.674 33.685 -9.805  1.00 19.16 ? 8   TYR A CE2  1 
ATOM   22   C CZ   . TYR A 1 42  ? -41.888 32.327 -9.740  1.00 20.31 ? 8   TYR A CZ   1 
ATOM   23   O OH   . TYR A 1 42  ? -40.834 31.480 -9.483  1.00 23.48 ? 8   TYR A OH   1 
ATOM   24   H H    . TYR A 1 42  ? -47.241 36.232 -10.722 1.00 33.60 ? 8   TYR A H    1 
ATOM   25   H HA   . TYR A 1 42  ? -46.603 33.982 -9.445  1.00 26.99 ? 8   TYR A HA   1 
ATOM   26   H HB2  . TYR A 1 42  ? -45.503 34.748 -11.433 1.00 34.25 ? 8   TYR A HB2  1 
ATOM   27   H HB3  . TYR A 1 42  ? -44.819 35.874 -10.544 1.00 34.25 ? 8   TYR A HB3  1 
ATOM   28   H HD1  . TYR A 1 42  ? -45.059 32.312 -10.321 1.00 26.43 ? 8   TYR A HD1  1 
ATOM   29   H HD2  . TYR A 1 42  ? -42.587 35.447 -10.116 1.00 28.34 ? 8   TYR A HD2  1 
ATOM   30   H HE1  . TYR A 1 42  ? -43.295 30.893 -9.881  1.00 28.23 ? 8   TYR A HE1  1 
ATOM   31   H HE2  . TYR A 1 42  ? -40.821 34.031 -9.674  1.00 23.02 ? 8   TYR A HE2  1 
ATOM   32   H HH   . TYR A 1 42  ? -40.108 31.895 -9.554  1.00 28.20 ? 8   TYR A HH   1 
ATOM   33   N N    . TYR A 1 43  ? -45.466 36.692 -8.163  1.00 20.11 ? 9   TYR A N    1 
ATOM   34   C CA   . TYR A 1 43  ? -45.073 37.339 -6.925  1.00 19.52 ? 9   TYR A CA   1 
ATOM   35   C C    . TYR A 1 43  ? -46.297 37.846 -6.172  1.00 23.16 ? 9   TYR A C    1 
ATOM   36   O O    . TYR A 1 43  ? -47.357 38.062 -6.764  1.00 20.45 ? 9   TYR A O    1 
ATOM   37   C CB   . TYR A 1 43  ? -44.146 38.515 -7.219  1.00 22.33 ? 9   TYR A CB   1 
ATOM   38   C CG   . TYR A 1 43  ? -42.686 38.164 -7.413  1.00 18.71 ? 9   TYR A CG   1 
ATOM   39   C CD1  . TYR A 1 43  ? -42.276 36.851 -7.607  1.00 21.55 ? 9   TYR A CD1  1 
ATOM   40   C CD2  . TYR A 1 43  ? -41.716 39.158 -7.410  1.00 19.75 ? 9   TYR A CD2  1 
ATOM   41   C CE1  . TYR A 1 43  ? -40.942 36.539 -7.784  1.00 15.97 ? 9   TYR A CE1  1 
ATOM   42   C CE2  . TYR A 1 43  ? -40.383 38.856 -7.588  1.00 19.47 ? 9   TYR A CE2  1 
ATOM   43   C CZ   . TYR A 1 43  ? -40.000 37.545 -7.772  1.00 18.37 ? 9   TYR A CZ   1 
ATOM   44   O OH   . TYR A 1 43  ? -38.670 37.242 -7.950  1.00 19.07 ? 9   TYR A OH   1 
ATOM   45   H H    . TYR A 1 43  ? -45.359 37.187 -8.858  1.00 24.16 ? 9   TYR A H    1 
ATOM   46   H HA   . TYR A 1 43  ? -44.602 36.701 -6.366  1.00 23.45 ? 9   TYR A HA   1 
ATOM   47   H HB2  . TYR A 1 43  ? -44.450 38.946 -8.034  1.00 26.83 ? 9   TYR A HB2  1 
ATOM   48   H HB3  . TYR A 1 43  ? -44.197 39.137 -6.477  1.00 26.83 ? 9   TYR A HB3  1 
ATOM   49   H HD1  . TYR A 1 43  ? -42.910 36.171 -7.618  1.00 25.89 ? 9   TYR A HD1  1 
ATOM   50   H HD2  . TYR A 1 43  ? -41.970 40.043 -7.285  1.00 23.73 ? 9   TYR A HD2  1 
ATOM   51   H HE1  . TYR A 1 43  ? -40.681 35.656 -7.909  1.00 19.19 ? 9   TYR A HE1  1 
ATOM   52   H HE2  . TYR A 1 43  ? -39.745 39.532 -7.583  1.00 23.39 ? 9   TYR A HE2  1 
ATOM   53   H HH   . TYR A 1 43  ? -38.207 37.941 -7.898  1.00 22.91 ? 9   TYR A HH   1 
ATOM   54   N N    . PRO A 1 44  ? -46.175 38.062 -4.863  1.00 21.25 ? 10  PRO A N    1 
ATOM   55   C CA   . PRO A 1 44  ? -47.240 38.772 -4.148  1.00 23.11 ? 10  PRO A CA   1 
ATOM   56   C C    . PRO A 1 44  ? -47.342 40.202 -4.652  1.00 21.89 ? 10  PRO A C    1 
ATOM   57   O O    . PRO A 1 44  ? -46.334 40.844 -4.957  1.00 20.95 ? 10  PRO A O    1 
ATOM   58   C CB   . PRO A 1 44  ? -46.804 38.719 -2.678  1.00 23.32 ? 10  PRO A CB   1 
ATOM   59   C CG   . PRO A 1 44  ? -45.485 38.041 -2.632  1.00 21.54 ? 10  PRO A CG   1 
ATOM   60   C CD   . PRO A 1 44  ? -45.002 37.783 -4.017  1.00 20.35 ? 10  PRO A CD   1 
ATOM   61   H HA   . PRO A 1 44  ? -48.090 38.315 -4.239  1.00 27.76 ? 10  PRO A HA   1 
ATOM   62   H HB2  . PRO A 1 44  ? -46.732 39.623 -2.332  1.00 28.01 ? 10  PRO A HB2  1 
ATOM   63   H HB3  . PRO A 1 44  ? -47.459 38.220 -2.167  1.00 28.01 ? 10  PRO A HB3  1 
ATOM   64   H HG2  . PRO A 1 44  ? -44.856 38.614 -2.166  1.00 25.87 ? 10  PRO A HG2  1 
ATOM   65   H HG3  . PRO A 1 44  ? -45.584 37.201 -2.157  1.00 25.87 ? 10  PRO A HG3  1 
ATOM   66   H HD2  . PRO A 1 44  ? -44.270 38.379 -4.241  1.00 24.45 ? 10  PRO A HD2  1 
ATOM   67   H HD3  . PRO A 1 44  ? -44.721 36.860 -4.116  1.00 24.45 ? 10  PRO A HD3  1 
ATOM   68   N N    . GLU A 1 45  ? -48.573 40.694 -4.752  1.00 20.25 ? 11  GLU A N    1 
ATOM   69   C CA   . GLU A 1 45  ? -48.796 42.057 -5.215  1.00 21.71 ? 11  GLU A CA   1 
ATOM   70   C C    . GLU A 1 45  ? -48.041 43.038 -4.327  1.00 19.61 ? 11  GLU A C    1 
ATOM   71   O O    . GLU A 1 45  ? -48.290 43.114 -3.119  1.00 17.58 ? 11  GLU A O    1 
ATOM   72   C CB   . GLU A 1 45  ? -50.291 42.367 -5.217  1.00 28.87 ? 11  GLU A CB   1 
ATOM   73   C CG   . GLU A 1 45  ? -50.669 43.589 -6.033  1.00 33.65 ? 11  GLU A CG   1 
ATOM   74   C CD   . GLU A 1 45  ? -52.169 43.767 -6.145  1.00 37.79 ? 11  GLU A CD   1 
ATOM   75   O OE1  . GLU A 1 45  ? -52.778 43.133 -7.031  1.00 41.60 ? 11  GLU A OE1  1 
ATOM   76   O OE2  . GLU A 1 45  ? -52.740 44.537 -5.344  1.00 41.26 ? 11  GLU A OE2  1 
ATOM   77   H H    . GLU A 1 45  ? -49.290 40.261 -4.560  1.00 24.32 ? 11  GLU A H    1 
ATOM   78   H HA   . GLU A 1 45  ? -48.469 42.151 -6.123  1.00 26.08 ? 11  GLU A HA   1 
ATOM   79   H HB2  . GLU A 1 45  ? -50.766 41.606 -5.588  1.00 34.68 ? 11  GLU A HB2  1 
ATOM   80   H HB3  . GLU A 1 45  ? -50.578 42.522 -4.303  1.00 34.68 ? 11  GLU A HB3  1 
ATOM   81   H HG2  . GLU A 1 45  ? -50.302 44.380 -5.607  1.00 40.40 ? 11  GLU A HG2  1 
ATOM   82   H HG3  . GLU A 1 45  ? -50.308 43.496 -6.928  1.00 40.40 ? 11  GLU A HG3  1 
ATOM   83   N N    . PHE A 1 46  ? -47.114 43.779 -4.929  1.00 15.62 ? 12  PHE A N    1 
ATOM   84   C CA   . PHE A 1 46  ? -46.234 44.697 -4.220  1.00 23.40 ? 12  PHE A CA   1 
ATOM   85   C C    . PHE A 1 46  ? -46.694 46.137 -4.413  1.00 20.37 ? 12  PHE A C    1 
ATOM   86   O O    . PHE A 1 46  ? -47.234 46.501 -5.461  1.00 21.33 ? 12  PHE A O    1 
ATOM   87   C CB   . PHE A 1 46  ? -44.792 44.541 -4.714  1.00 18.09 ? 12  PHE A CB   1 
ATOM   88   C CG   . PHE A 1 46  ? -43.814 45.470 -4.050  1.00 21.11 ? 12  PHE A CG   1 
ATOM   89   C CD1  . PHE A 1 46  ? -43.202 45.118 -2.859  1.00 19.73 ? 12  PHE A CD1  1 
ATOM   90   C CD2  . PHE A 1 46  ? -43.498 46.692 -4.624  1.00 22.00 ? 12  PHE A CD2  1 
ATOM   91   C CE1  . PHE A 1 46  ? -42.298 45.969 -2.248  1.00 18.68 ? 12  PHE A CE1  1 
ATOM   92   C CE2  . PHE A 1 46  ? -42.595 47.546 -4.017  1.00 19.37 ? 12  PHE A CE2  1 
ATOM   93   C CZ   . PHE A 1 46  ? -41.996 47.183 -2.827  1.00 19.80 ? 12  PHE A CZ   1 
ATOM   94   H H    . PHE A 1 46  ? -46.973 43.766 -5.777  1.00 18.77 ? 12  PHE A H    1 
ATOM   95   H HA   . PHE A 1 46  ? -46.258 44.501 -3.271  1.00 28.10 ? 12  PHE A HA   1 
ATOM   96   H HB2  . PHE A 1 46  ? -44.500 43.632 -4.541  1.00 21.73 ? 12  PHE A HB2  1 
ATOM   97   H HB3  . PHE A 1 46  ? -44.769 44.720 -5.667  1.00 21.73 ? 12  PHE A HB3  1 
ATOM   98   H HD1  . PHE A 1 46  ? -43.401 44.299 -2.465  1.00 23.70 ? 12  PHE A HD1  1 
ATOM   99   H HD2  . PHE A 1 46  ? -43.898 46.940 -5.426  1.00 26.43 ? 12  PHE A HD2  1 
ATOM   100  H HE1  . PHE A 1 46  ? -41.895 45.723 -1.447  1.00 22.45 ? 12  PHE A HE1  1 
ATOM   101  H HE2  . PHE A 1 46  ? -42.392 48.364 -4.409  1.00 23.27 ? 12  PHE A HE2  1 
ATOM   102  H HZ   . PHE A 1 46  ? -41.388 47.756 -2.418  1.00 23.78 ? 12  PHE A HZ   1 
ATOM   103  N N    . SER A 1 47  ? -46.468 46.960 -3.390  1.00 19.94 ? 13  SER A N    1 
ATOM   104  C CA   . SER A 1 47  ? -46.843 48.366 -3.443  1.00 22.60 ? 13  SER A CA   1 
ATOM   105  C C    . SER A 1 47  ? -45.931 49.176 -2.531  1.00 20.30 ? 13  SER A C    1 
ATOM   106  O O    . SER A 1 47  ? -45.595 48.736 -1.429  1.00 19.66 ? 13  SER A O    1 
ATOM   107  C CB   . SER A 1 47  ? -48.306 48.566 -3.029  1.00 26.68 ? 13  SER A CB   1 
ATOM   108  O OG   . SER A 1 47  ? -48.575 49.932 -2.765  1.00 22.63 ? 13  SER A OG   1 
ATOM   109  H H    . SER A 1 47  ? -46.098 46.723 -2.651  1.00 23.95 ? 13  SER A H    1 
ATOM   110  H HA   . SER A 1 47  ? -46.724 48.691 -4.349  1.00 27.15 ? 13  SER A HA   1 
ATOM   111  H HB2  . SER A 1 47  ? -48.881 48.265 -3.749  1.00 32.04 ? 13  SER A HB2  1 
ATOM   112  H HB3  . SER A 1 47  ? -48.480 48.050 -2.226  1.00 32.04 ? 13  SER A HB3  1 
ATOM   113  H HG   . SER A 1 47  ? -48.442 50.389 -3.457  1.00 27.19 ? 13  SER A HG   1 
ATOM   114  N N    . TRP A 1 48  ? -45.542 50.363 -2.999  1.00 21.10 ? 14  TRP A N    1 
ATOM   115  C CA   . TRP A 1 48  ? -44.784 51.316 -2.198  1.00 21.12 ? 14  TRP A CA   1 
ATOM   116  C C    . TRP A 1 48  ? -45.676 52.247 -1.383  1.00 24.28 ? 14  TRP A C    1 
ATOM   117  O O    . TRP A 1 48  ? -45.152 53.120 -0.682  1.00 20.69 ? 14  TRP A O    1 
ATOM   118  C CB   . TRP A 1 48  ? -43.882 52.176 -3.092  1.00 19.67 ? 14  TRP A CB   1 
ATOM   119  C CG   . TRP A 1 48  ? -42.715 51.475 -3.725  1.00 20.37 ? 14  TRP A CG   1 
ATOM   120  C CD1  . TRP A 1 48  ? -42.552 51.200 -5.052  1.00 18.47 ? 14  TRP A CD1  1 
ATOM   121  C CD2  . TRP A 1 48  ? -41.534 50.992 -3.069  1.00 20.13 ? 14  TRP A CD2  1 
ATOM   122  N NE1  . TRP A 1 48  ? -41.352 50.568 -5.261  1.00 21.33 ? 14  TRP A NE1  1 
ATOM   123  C CE2  . TRP A 1 48  ? -40.708 50.427 -4.061  1.00 20.77 ? 14  TRP A CE2  1 
ATOM   124  C CE3  . TRP A 1 48  ? -41.099 50.976 -1.740  1.00 16.25 ? 14  TRP A CE3  1 
ATOM   125  C CZ2  . TRP A 1 48  ? -39.473 49.853 -3.766  1.00 19.19 ? 14  TRP A CZ2  1 
ATOM   126  C CZ3  . TRP A 1 48  ? -39.871 50.404 -1.450  1.00 18.78 ? 14  TRP A CZ3  1 
ATOM   127  C CH2  . TRP A 1 48  ? -39.073 49.851 -2.459  1.00 16.94 ? 14  TRP A CH2  1 
ATOM   128  H H    . TRP A 1 48  ? -45.710 50.642 -3.795  1.00 25.35 ? 14  TRP A H    1 
ATOM   129  H HA   . TRP A 1 48  ? -44.222 50.809 -1.591  1.00 25.37 ? 14  TRP A HA   1 
ATOM   130  H HB2  . TRP A 1 48  ? -44.423 52.537 -3.811  1.00 23.63 ? 14  TRP A HB2  1 
ATOM   131  H HB3  . TRP A 1 48  ? -43.522 52.898 -2.553  1.00 23.63 ? 14  TRP A HB3  1 
ATOM   132  H HD1  . TRP A 1 48  ? -43.166 51.410 -5.718  1.00 22.19 ? 14  TRP A HD1  1 
ATOM   133  H HE1  . TRP A 1 48  ? -41.053 50.303 -6.023  1.00 25.63 ? 14  TRP A HE1  1 
ATOM   134  H HE3  . TRP A 1 48  ? -41.623 51.342 -1.064  1.00 19.52 ? 14  TRP A HE3  1 
ATOM   135  H HZ2  . TRP A 1 48  ? -38.940 49.485 -4.434  1.00 23.05 ? 14  TRP A HZ2  1 
ATOM   136  H HZ3  . TRP A 1 48  ? -39.572 50.387 -0.570  1.00 22.56 ? 14  TRP A HZ3  1 
ATOM   137  H HH2  . TRP A 1 48  ? -38.253 49.475 -2.234  1.00 20.35 ? 14  TRP A HH2  1 
ATOM   138  N N    . LYS A 1 49  ? -47.001 52.095 -1.468  1.00 22.32 ? 15  LYS A N    1 
ATOM   139  C CA   . LYS A 1 49  ? -47.910 53.047 -0.830  1.00 21.26 ? 15  LYS A CA   1 
ATOM   140  C C    . LYS A 1 49  ? -47.549 53.258 0.635   1.00 21.41 ? 15  LYS A C    1 
ATOM   141  O O    . LYS A 1 49  ? -47.516 54.394 1.125   1.00 19.03 ? 15  LYS A O    1 
ATOM   142  C CB   . LYS A 1 49  ? -49.353 52.557 -0.964  1.00 21.15 ? 15  LYS A CB   1 
ATOM   143  H H    . LYS A 1 49  ? -47.395 51.455 -1.885  1.00 26.81 ? 15  LYS A H    1 
ATOM   144  H HA   . LYS A 1 49  ? -47.836 53.901 -1.283  1.00 25.54 ? 15  LYS A HA   1 
ATOM   145  N N    . THR A 1 50  ? -47.296 52.169 1.353   1.00 19.26 ? 16  THR A N    1 
ATOM   146  C CA   . THR A 1 50  ? -46.736 52.196 2.695   1.00 17.20 ? 16  THR A CA   1 
ATOM   147  C C    . THR A 1 50  ? -45.511 51.292 2.708   1.00 18.21 ? 16  THR A C    1 
ATOM   148  O O    . THR A 1 50  ? -45.168 50.662 1.703   1.00 17.92 ? 16  THR A O    1 
ATOM   149  C CB   . THR A 1 50  ? -47.758 51.744 3.746   1.00 19.59 ? 16  THR A CB   1 
ATOM   150  O OG1  . THR A 1 50  ? -48.178 50.403 3.464   1.00 20.04 ? 16  THR A OG1  1 
ATOM   151  C CG2  . THR A 1 50  ? -48.973 52.665 3.753   1.00 23.81 ? 16  THR A CG2  1 
ATOM   152  H H    . THR A 1 50  ? -47.448 51.371 1.070   1.00 23.14 ? 16  THR A H    1 
ATOM   153  H HA   . THR A 1 50  ? -46.470 53.102 2.916   1.00 20.66 ? 16  THR A HA   1 
ATOM   154  H HB   . THR A 1 50  ? -47.349 51.777 4.625   1.00 23.54 ? 16  THR A HB   1 
ATOM   155  H HG1  . THR A 1 50  ? -47.551 49.867 3.622   1.00 24.07 ? 16  THR A HG1  1 
ATOM   156  H HG21 . THR A 1 50  ? -49.621 52.354 4.404   1.00 28.60 ? 16  THR A HG21 1 
ATOM   157  H HG22 . THR A 1 50  ? -48.703 53.568 3.984   1.00 28.60 ? 16  THR A HG22 1 
ATOM   158  H HG23 . THR A 1 50  ? -49.387 52.674 2.876   1.00 28.60 ? 16  THR A HG23 1 
ATOM   159  N N    . VAL A 1 51  ? -44.844 51.223 3.853   1.00 18.23 ? 17  VAL A N    1 
ATOM   160  C CA   . VAL A 1 51  ? -43.675 50.358 3.980   1.00 18.81 ? 17  VAL A CA   1 
ATOM   161  C C    . VAL A 1 51  ? -44.113 48.939 3.641   1.00 17.55 ? 17  VAL A C    1 
ATOM   162  O O    . VAL A 1 51  ? -45.023 48.407 4.292   1.00 18.74 ? 17  VAL A O    1 
ATOM   163  C CB   . VAL A 1 51  ? -43.063 50.429 5.385   1.00 15.71 ? 17  VAL A CB   1 
ATOM   164  C CG1  . VAL A 1 51  ? -42.013 49.334 5.551   1.00 16.54 ? 17  VAL A CG1  1 
ATOM   165  C CG2  . VAL A 1 51  ? -42.462 51.803 5.628   1.00 20.88 ? 17  VAL A CG2  1 
ATOM   166  H H    . VAL A 1 51  ? -45.045 51.662 4.564   1.00 21.90 ? 17  VAL A H    1 
ATOM   167  H HA   . VAL A 1 51  ? -42.993 50.642 3.352   1.00 22.60 ? 17  VAL A HA   1 
ATOM   168  H HB   . VAL A 1 51  ? -43.755 50.286 6.049   1.00 18.88 ? 17  VAL A HB   1 
ATOM   169  H HG11 . VAL A 1 51  ? -41.446 49.553 6.307   1.00 19.87 ? 17  VAL A HG11 1 
ATOM   170  H HG12 . VAL A 1 51  ? -42.461 48.488 5.707   1.00 19.87 ? 17  VAL A HG12 1 
ATOM   171  H HG13 . VAL A 1 51  ? -41.481 49.282 4.742   1.00 19.87 ? 17  VAL A HG13 1 
ATOM   172  H HG21 . VAL A 1 51  ? -42.056 51.819 6.509   1.00 25.09 ? 17  VAL A HG21 1 
ATOM   173  H HG22 . VAL A 1 51  ? -41.790 51.979 4.951   1.00 25.09 ? 17  VAL A HG22 1 
ATOM   174  H HG23 . VAL A 1 51  ? -43.165 52.469 5.577   1.00 25.09 ? 17  VAL A HG23 1 
ATOM   175  N N    . PRO A 1 52  ? -43.527 48.294 2.631   1.00 16.69 ? 18  PRO A N    1 
ATOM   176  C CA   . PRO A 1 52  ? -43.908 46.906 2.338   1.00 18.20 ? 18  PRO A CA   1 
ATOM   177  C C    . PRO A 1 52  ? -43.482 45.988 3.474   1.00 19.50 ? 18  PRO A C    1 
ATOM   178  O O    . PRO A 1 52  ? -42.320 45.988 3.886   1.00 20.52 ? 18  PRO A O    1 
ATOM   179  C CB   . PRO A 1 52  ? -43.162 46.591 1.036   1.00 17.38 ? 18  PRO A CB   1 
ATOM   180  C CG   . PRO A 1 52  ? -42.060 47.586 0.956   1.00 18.59 ? 18  PRO A CG   1 
ATOM   181  C CD   . PRO A 1 52  ? -42.504 48.805 1.700   1.00 22.52 ? 18  PRO A CD   1 
ATOM   182  H HA   . PRO A 1 52  ? -44.863 46.828 2.187   1.00 21.87 ? 18  PRO A HA   1 
ATOM   183  H HB2  . PRO A 1 52  ? -42.810 45.688 1.070   1.00 20.89 ? 18  PRO A HB2  1 
ATOM   184  H HB3  . PRO A 1 52  ? -43.766 46.683 0.282   1.00 20.89 ? 18  PRO A HB3  1 
ATOM   185  H HG2  . PRO A 1 52  ? -41.262 47.215 1.363   1.00 22.34 ? 18  PRO A HG2  1 
ATOM   186  H HG3  . PRO A 1 52  ? -41.889 47.802 0.026   1.00 22.34 ? 18  PRO A HG3  1 
ATOM   187  H HD2  . PRO A 1 52  ? -41.764 49.200 2.187   1.00 27.05 ? 18  PRO A HD2  1 
ATOM   188  H HD3  . PRO A 1 52  ? -42.888 49.458 1.093   1.00 27.05 ? 18  PRO A HD3  1 
ATOM   189  N N    . VAL A 1 53  ? -44.436 45.215 3.989   1.00 17.50 ? 19  VAL A N    1 
ATOM   190  C CA   . VAL A 1 53  ? -44.186 44.326 5.115   1.00 20.81 ? 19  VAL A CA   1 
ATOM   191  C C    . VAL A 1 53  ? -44.609 42.911 4.752   1.00 18.71 ? 19  VAL A C    1 
ATOM   192  O O    . VAL A 1 53  ? -45.476 42.694 3.899   1.00 19.44 ? 19  VAL A O    1 
ATOM   193  C CB   . VAL A 1 53  ? -44.912 44.789 6.402   1.00 19.76 ? 19  VAL A CB   1 
ATOM   194  C CG1  . VAL A 1 53  ? -44.715 46.280 6.621   1.00 20.59 ? 19  VAL A CG1  1 
ATOM   195  C CG2  . VAL A 1 53  ? -46.398 44.440 6.350   1.00 28.32 ? 19  VAL A CG2  1 
ATOM   196  H H    . VAL A 1 53  ? -45.244 45.189 3.698   1.00 21.03 ? 19  VAL A H    1 
ATOM   197  H HA   . VAL A 1 53  ? -43.231 44.319 5.289   1.00 25.00 ? 19  VAL A HA   1 
ATOM   198  H HB   . VAL A 1 53  ? -44.526 44.319 7.158   1.00 23.74 ? 19  VAL A HB   1 
ATOM   199  H HG11 . VAL A 1 53  ? -45.131 46.534 7.460   1.00 24.73 ? 19  VAL A HG11 1 
ATOM   200  H HG12 . VAL A 1 53  ? -43.765 46.472 6.652   1.00 24.73 ? 19  VAL A HG12 1 
ATOM   201  H HG13 . VAL A 1 53  ? -45.127 46.764 5.888   1.00 24.73 ? 19  VAL A HG13 1 
ATOM   202  H HG21 . VAL A 1 53  ? -46.836 44.806 7.134   1.00 34.01 ? 19  VAL A HG21 1 
ATOM   203  H HG22 . VAL A 1 53  ? -46.784 44.823 5.547   1.00 34.01 ? 19  VAL A HG22 1 
ATOM   204  H HG23 . VAL A 1 53  ? -46.496 43.475 6.336   1.00 34.01 ? 19  VAL A HG23 1 
ATOM   205  N N    . ALA A 1 54  ? -43.982 41.946 5.415   1.00 20.96 ? 20  ALA A N    1 
ATOM   206  C CA   . ALA A 1 54  ? -44.316 40.537 5.298   1.00 17.41 ? 20  ALA A CA   1 
ATOM   207  C C    . ALA A 1 54  ? -44.462 39.962 6.700   1.00 18.12 ? 20  ALA A C    1 
ATOM   208  O O    . ALA A 1 54  ? -44.159 40.620 7.698   1.00 14.67 ? 20  ALA A O    1 
ATOM   209  C CB   . ALA A 1 54  ? -43.248 39.772 4.507   1.00 18.97 ? 20  ALA A CB   1 
ATOM   210  H H    . ALA A 1 54  ? -43.333 42.091 5.961   1.00 25.18 ? 20  ALA A H    1 
ATOM   211  H HA   . ALA A 1 54  ? -45.159 40.434 4.829   1.00 20.92 ? 20  ALA A HA   1 
ATOM   212  H HB1  . ALA A 1 54  ? -43.527 38.848 4.412   1.00 22.79 ? 20  ALA A HB1  1 
ATOM   213  H HB2  . ALA A 1 54  ? -43.151 40.179 3.632   1.00 22.79 ? 20  ALA A HB2  1 
ATOM   214  H HB3  . ALA A 1 54  ? -42.407 39.816 4.988   1.00 22.79 ? 20  ALA A HB3  1 
ATOM   215  N N    . PHE A 1 55  ? -44.936 38.721 6.773   1.00 14.17 ? 21  PHE A N    1 
ATOM   216  C CA   . PHE A 1 55  ? -45.062 38.017 8.040   1.00 17.83 ? 21  PHE A CA   1 
ATOM   217  C C    . PHE A 1 55  ? -44.329 36.687 7.965   1.00 15.75 ? 21  PHE A C    1 
ATOM   218  O O    . PHE A 1 55  ? -44.286 36.036 6.918   1.00 14.34 ? 21  PHE A O    1 
ATOM   219  C CB   . PHE A 1 55  ? -46.531 37.786 8.418   1.00 18.46 ? 21  PHE A CB   1 
ATOM   220  C CG   . PHE A 1 55  ? -47.266 39.045 8.768   1.00 20.09 ? 21  PHE A CG   1 
ATOM   221  C CD1  . PHE A 1 55  ? -47.866 39.807 7.783   1.00 14.93 ? 21  PHE A CD1  1 
ATOM   222  C CD2  . PHE A 1 55  ? -47.345 39.473 10.084  1.00 18.14 ? 21  PHE A CD2  1 
ATOM   223  C CE1  . PHE A 1 55  ? -48.542 40.969 8.103   1.00 15.97 ? 21  PHE A CE1  1 
ATOM   224  C CE2  . PHE A 1 55  ? -48.017 40.634 10.409  1.00 21.02 ? 21  PHE A CE2  1 
ATOM   225  C CZ   . PHE A 1 55  ? -48.615 41.384 9.416   1.00 21.77 ? 21  PHE A CZ   1 
ATOM   226  H H    . PHE A 1 55  ? -45.194 38.263 6.093   1.00 17.03 ? 21  PHE A H    1 
ATOM   227  H HA   . PHE A 1 55  ? -44.653 38.546 8.742   1.00 21.42 ? 21  PHE A HA   1 
ATOM   228  H HB2  . PHE A 1 55  ? -46.986 37.376 7.666   1.00 22.18 ? 21  PHE A HB2  1 
ATOM   229  H HB3  . PHE A 1 55  ? -46.567 37.197 9.188   1.00 22.18 ? 21  PHE A HB3  1 
ATOM   230  H HD1  . PHE A 1 55  ? -47.815 39.534 6.896   1.00 17.94 ? 21  PHE A HD1  1 
ATOM   231  H HD2  . PHE A 1 55  ? -46.940 38.973 10.755  1.00 21.79 ? 21  PHE A HD2  1 
ATOM   232  H HE1  . PHE A 1 55  ? -48.946 41.472 7.433   1.00 19.20 ? 21  PHE A HE1  1 
ATOM   233  H HE2  . PHE A 1 55  ? -48.066 40.911 11.295  1.00 25.25 ? 21  PHE A HE2  1 
ATOM   234  H HZ   . PHE A 1 55  ? -49.068 42.167 9.633   1.00 26.15 ? 21  PHE A HZ   1 
ATOM   235  N N    . HIS A 1 56  ? -43.752 36.294 9.099   1.00 16.83 ? 22  HIS A N    1 
ATOM   236  C CA   . HIS A 1 56  ? -42.992 35.050 9.197   1.00 15.38 ? 22  HIS A CA   1 
ATOM   237  C C    . HIS A 1 56  ? -43.149 34.556 10.631  1.00 19.54 ? 22  HIS A C    1 
ATOM   238  O O    . HIS A 1 56  ? -42.437 35.021 11.526  1.00 14.93 ? 22  HIS A O    1 
ATOM   239  C CB   . HIS A 1 56  ? -41.530 35.275 8.837   1.00 20.69 ? 22  HIS A CB   1 
ATOM   240  C CG   . HIS A 1 56  ? -40.683 34.045 8.933   1.00 18.41 ? 22  HIS A CG   1 
ATOM   241  N ND1  . HIS A 1 56  ? -39.336 34.049 8.648   1.00 33.45 ? 22  HIS A ND1  1 
ATOM   242  C CD2  . HIS A 1 56  ? -40.991 32.771 9.270   1.00 23.82 ? 22  HIS A CD2  1 
ATOM   243  C CE1  . HIS A 1 56  ? -38.848 32.833 8.811   1.00 32.73 ? 22  HIS A CE1  1 
ATOM   244  N NE2  . HIS A 1 56  ? -39.832 32.038 9.188   1.00 28.41 ? 22  HIS A NE2  1 
ATOM   245  H H    . HIS A 1 56  ? -43.786 36.737 9.835   1.00 20.23 ? 22  HIS A H    1 
ATOM   246  H HA   . HIS A 1 56  ? -43.356 34.387 8.591   1.00 18.48 ? 22  HIS A HA   1 
ATOM   247  H HB2  . HIS A 1 56  ? -41.480 35.597 7.924   1.00 24.86 ? 22  HIS A HB2  1 
ATOM   248  H HB3  . HIS A 1 56  ? -41.159 35.937 9.442   1.00 24.86 ? 22  HIS A HB3  1 
ATOM   249  H HD2  . HIS A 1 56  ? -41.830 32.452 9.511   1.00 28.61 ? 22  HIS A HD2  1 
ATOM   250  H HE1  . HIS A 1 56  ? -37.962 32.580 8.682   1.00 39.30 ? 22  HIS A HE1  1 
ATOM   251  H HE2  . HIS A 1 56  ? -39.759 31.198 9.356   1.00 34.12 ? 22  HIS A HE2  1 
ATOM   252  N N    . PHE A 1 57  ? -44.074 33.624 10.848  1.00 19.61 ? 23  PHE A N    1 
ATOM   253  C CA   . PHE A 1 57  ? -44.363 33.191 12.207  1.00 15.53 ? 23  PHE A CA   1 
ATOM   254  C C    . PHE A 1 57  ? -45.060 31.840 12.195  1.00 16.60 ? 23  PHE A C    1 
ATOM   255  O O    . PHE A 1 57  ? -45.515 31.352 11.157  1.00 15.21 ? 23  PHE A O    1 
ATOM   256  C CB   . PHE A 1 57  ? -45.220 34.229 12.943  1.00 16.80 ? 23  PHE A CB   1 
ATOM   257  C CG   . PHE A 1 57  ? -46.593 34.415 12.354  1.00 18.45 ? 23  PHE A CG   1 
ATOM   258  C CD1  . PHE A 1 57  ? -47.573 33.442 12.504  1.00 18.47 ? 23  PHE A CD1  1 
ATOM   259  C CD2  . PHE A 1 57  ? -46.907 35.568 11.655  1.00 20.39 ? 23  PHE A CD2  1 
ATOM   260  C CE1  . PHE A 1 57  ? -48.830 33.613 11.961  1.00 18.00 ? 23  PHE A CE1  1 
ATOM   261  C CE2  . PHE A 1 57  ? -48.167 35.746 11.113  1.00 19.80 ? 23  PHE A CE2  1 
ATOM   262  C CZ   . PHE A 1 57  ? -49.130 34.766 11.269  1.00 16.33 ? 23  PHE A CZ   1 
ATOM   263  H H    . PHE A 1 57  ? -44.538 33.237 10.235  1.00 23.56 ? 23  PHE A H    1 
ATOM   264  H HA   . PHE A 1 57  ? -43.519 33.077 12.671  1.00 18.67 ? 23  PHE A HA   1 
ATOM   265  H HB2  . PHE A 1 57  ? -45.329 33.945 13.864  1.00 20.19 ? 23  PHE A HB2  1 
ATOM   266  H HB3  . PHE A 1 57  ? -44.767 35.086 12.912  1.00 20.19 ? 23  PHE A HB3  1 
ATOM   267  H HD1  . PHE A 1 57  ? -47.379 32.665 12.976  1.00 22.20 ? 23  PHE A HD1  1 
ATOM   268  H HD2  . PHE A 1 57  ? -46.263 36.230 11.548  1.00 24.49 ? 23  PHE A HD2  1 
ATOM   269  H HE1  . PHE A 1 57  ? -49.475 32.950 12.062  1.00 21.62 ? 23  PHE A HE1  1 
ATOM   270  H HE2  . PHE A 1 57  ? -48.367 36.524 10.644  1.00 23.79 ? 23  PHE A HE2  1 
ATOM   271  H HZ   . PHE A 1 57  ? -49.978 34.885 10.908  1.00 19.63 ? 23  PHE A HZ   1 
ATOM   272  N N    . ALA A 1 58  ? -45.146 31.248 13.385  1.00 17.39 ? 24  ALA A N    1 
ATOM   273  C CA   . ALA A 1 58  ? -45.972 30.080 13.642  1.00 16.35 ? 24  ALA A CA   1 
ATOM   274  C C    . ALA A 1 58  ? -46.747 30.312 14.930  1.00 19.03 ? 24  ALA A C    1 
ATOM   275  O O    . ALA A 1 58  ? -46.160 30.681 15.954  1.00 20.30 ? 24  ALA A O    1 
ATOM   276  C CB   . ALA A 1 58  ? -45.132 28.801 13.752  1.00 22.15 ? 24  ALA A CB   1 
ATOM   277  H H    . ALA A 1 58  ? -44.718 31.518 14.081  1.00 20.90 ? 24  ALA A H    1 
ATOM   278  H HA   . ALA A 1 58  ? -46.600 29.958 12.912  1.00 19.65 ? 24  ALA A HA   1 
ATOM   279  H HB1  . ALA A 1 58  ? -45.699 28.077 14.059  1.00 26.60 ? 24  ALA A HB1  1 
ATOM   280  H HB2  . ALA A 1 58  ? -44.766 28.588 12.879  1.00 26.60 ? 24  ALA A HB2  1 
ATOM   281  H HB3  . ALA A 1 58  ? -44.413 28.950 14.385  1.00 26.60 ? 24  ALA A HB3  1 
ATOM   282  N N    . LYS A 1 59  ? -48.063 30.134 14.862  1.00 19.02 ? 25  LYS A N    1 
ATOM   283  C CA   . LYS A 1 59  ? -48.910 30.036 16.048  1.00 22.77 ? 25  LYS A CA   1 
ATOM   284  C C    . LYS A 1 59  ? -48.815 28.602 16.550  1.00 21.52 ? 25  LYS A C    1 
ATOM   285  O O    . LYS A 1 59  ? -49.394 27.683 15.966  1.00 22.96 ? 25  LYS A O    1 
ATOM   286  C CB   . LYS A 1 59  ? -50.345 30.425 15.717  1.00 21.58 ? 25  LYS A CB   1 
ATOM   287  C CG   . LYS A 1 59  ? -51.189 30.749 16.932  1.00 25.39 ? 25  LYS A CG   1 
ATOM   288  C CD   . LYS A 1 59  ? -52.643 30.979 16.553  1.00 28.25 ? 25  LYS A CD   1 
ATOM   289  C CE   . LYS A 1 59  ? -53.505 31.222 17.780  1.00 26.37 ? 25  LYS A CE   1 
ATOM   290  N NZ   . LYS A 1 59  ? -54.886 31.638 17.411  1.00 25.18 ? 25  LYS A NZ   1 
ATOM   291  H H    . LYS A 1 59  ? -48.499 30.065 14.124  1.00 22.85 ? 25  LYS A H    1 
ATOM   292  H HA   . LYS A 1 59  ? -48.594 30.637 16.740  1.00 27.35 ? 25  LYS A HA   1 
ATOM   293  H HB2  . LYS A 1 59  ? -50.332 31.210 15.148  1.00 25.92 ? 25  LYS A HB2  1 
ATOM   294  H HB3  . LYS A 1 59  ? -50.768 29.686 15.252  1.00 25.92 ? 25  LYS A HB3  1 
ATOM   295  H HG2  . LYS A 1 59  ? -51.150 30.009 17.558  1.00 30.50 ? 25  LYS A HG2  1 
ATOM   296  H HG3  . LYS A 1 59  ? -50.852 31.556 17.351  1.00 30.50 ? 25  LYS A HG3  1 
ATOM   297  H HD2  . LYS A 1 59  ? -52.706 31.758 15.977  1.00 33.92 ? 25  LYS A HD2  1 
ATOM   298  H HD3  . LYS A 1 59  ? -52.982 30.197 16.091  1.00 33.92 ? 25  LYS A HD3  1 
ATOM   299  H HE2  . LYS A 1 59  ? -53.563 30.403 18.297  1.00 31.67 ? 25  LYS A HE2  1 
ATOM   300  H HE3  . LYS A 1 59  ? -53.109 31.926 18.316  1.00 31.67 ? 25  LYS A HE3  1 
ATOM   301  H HZ1  . LYS A 1 59  ? -55.351 31.835 18.144  1.00 30.25 ? 25  LYS A HZ1  1 
ATOM   302  H HZ2  . LYS A 1 59  ? -54.857 32.356 16.885  1.00 30.25 ? 25  LYS A HZ2  1 
ATOM   303  H HZ3  . LYS A 1 59  ? -55.297 30.979 16.977  1.00 30.25 ? 25  LYS A HZ3  1 
ATOM   304  N N    . ARG A 1 60  ? -48.074 28.404 17.640  1.00 23.37 ? 26  ARG A N    1 
ATOM   305  C CA   . ARG A 1 60  ? -47.734 27.058 18.084  1.00 21.53 ? 26  ARG A CA   1 
ATOM   306  C C    . ARG A 1 60  ? -48.884 26.342 18.781  1.00 25.97 ? 26  ARG A C    1 
ATOM   307  O O    . ARG A 1 60  ? -48.849 25.111 18.883  1.00 27.02 ? 26  ARG A O    1 
ATOM   308  C CB   . ARG A 1 60  ? -46.525 27.109 19.022  1.00 25.37 ? 26  ARG A CB   1 
ATOM   309  C CG   . ARG A 1 60  ? -45.227 27.588 18.366  1.00 31.87 ? 26  ARG A CG   1 
ATOM   310  C CD   . ARG A 1 60  ? -44.898 26.796 17.104  1.00 33.98 ? 26  ARG A CD   1 
ATOM   311  N NE   . ARG A 1 60  ? -43.575 27.110 16.574  1.00 33.12 ? 26  ARG A NE   1 
ATOM   312  C CZ   . ARG A 1 60  ? -42.448 26.525 16.958  1.00 38.20 ? 26  ARG A CZ   1 
ATOM   313  N NH1  . ARG A 1 60  ? -42.436 25.591 17.897  1.00 37.85 ? 26  ARG A NH1  1 
ATOM   314  N NH2  . ARG A 1 60  ? -41.303 26.884 16.384  1.00 37.68 ? 26  ARG A NH2  1 
ATOM   315  H H    . ARG A 1 60  ? -47.757 29.031 18.136  1.00 28.08 ? 26  ARG A H    1 
ATOM   316  H HA   . ARG A 1 60  ? -47.497 26.534 17.303  1.00 25.87 ? 26  ARG A HA   1 
ATOM   317  H HB2  . ARG A 1 60  ? -46.726 27.717 19.751  1.00 30.47 ? 26  ARG A HB2  1 
ATOM   318  H HB3  . ARG A 1 60  ? -46.366 26.217 19.368  1.00 30.47 ? 26  ARG A HB3  1 
ATOM   319  H HG2  . ARG A 1 60  ? -45.319 28.523 18.121  1.00 38.27 ? 26  ARG A HG2  1 
ATOM   320  H HG3  . ARG A 1 60  ? -44.494 27.480 18.992  1.00 38.27 ? 26  ARG A HG3  1 
ATOM   321  H HD2  . ARG A 1 60  ? -44.922 25.848 17.310  1.00 40.81 ? 26  ARG A HD2  1 
ATOM   322  H HD3  . ARG A 1 60  ? -45.553 27.004 16.420  1.00 40.81 ? 26  ARG A HD3  1 
ATOM   323  H HE   . ARG A 1 60  ? -43.522 27.719 15.969  1.00 39.77 ? 26  ARG A HE   1 
ATOM   324  H HH11 . ARG A 1 60  ? -43.171 25.351 18.274  1.00 45.45 ? 26  ARG A HH11 1 
ATOM   325  H HH12 . ARG A 1 60  ? -41.694 25.225 18.130  1.00 45.45 ? 26  ARG A HH12 1 
ATOM   326  H HH21 . ARG A 1 60  ? -41.300 27.489 15.773  1.00 45.24 ? 26  ARG A HH21 1 
ATOM   327  H HH22 . ARG A 1 60  ? -40.566 26.512 16.625  1.00 45.24 ? 26  ARG A HH22 1 
ATOM   328  N N    . ASN A 1 61  ? -49.897 27.064 19.259  1.00 22.74 ? 27  ASN A N    1 
ATOM   329  C CA   . ASN A 1 61  ? -50.969 26.448 20.031  1.00 30.63 ? 27  ASN A CA   1 
ATOM   330  C C    . ASN A 1 61  ? -52.222 26.160 19.211  1.00 27.82 ? 27  ASN A C    1 
ATOM   331  O O    . ASN A 1 61  ? -53.134 25.503 19.722  1.00 26.65 ? 27  ASN A O    1 
ATOM   332  C CB   . ASN A 1 61  ? -51.339 27.332 21.232  1.00 33.73 ? 27  ASN A CB   1 
ATOM   333  C CG   . ASN A 1 61  ? -51.670 28.757 20.833  1.00 38.24 ? 27  ASN A CG   1 
ATOM   334  O OD1  . ASN A 1 61  ? -51.470 29.157 19.689  1.00 40.37 ? 27  ASN A OD1  1 
ATOM   335  N ND2  . ASN A 1 61  ? -52.171 29.536 21.784  1.00 42.32 ? 27  ASN A ND2  1 
ATOM   336  H H    . ASN A 1 61  ? -49.983 27.912 19.148  1.00 27.31 ? 27  ASN A H    1 
ATOM   337  H HA   . ASN A 1 61  ? -50.646 25.600 20.374  1.00 36.78 ? 27  ASN A HA   1 
ATOM   338  H HB2  . ASN A 1 61  ? -52.116 26.956 21.674  1.00 40.51 ? 27  ASN A HB2  1 
ATOM   339  H HB3  . ASN A 1 61  ? -50.589 27.360 21.846  1.00 40.51 ? 27  ASN A HB3  1 
ATOM   340  H HD21 . ASN A 1 61  ? -52.291 29.224 22.577  1.00 50.81 ? 27  ASN A HD21 1 
ATOM   341  H HD22 . ASN A 1 61  ? -52.375 30.353 21.609  1.00 50.81 ? 27  ASN A HD22 1 
ATOM   342  N N    . GLY A 1 62  ? -52.290 26.616 17.967  1.00 25.57 ? 28  GLY A N    1 
ATOM   343  C CA   . GLY A 1 62  ? -53.446 26.338 17.141  1.00 25.45 ? 28  GLY A CA   1 
ATOM   344  C C    . GLY A 1 62  ? -53.453 27.216 15.907  1.00 22.50 ? 28  GLY A C    1 
ATOM   345  O O    . GLY A 1 62  ? -52.467 27.887 15.589  1.00 19.71 ? 28  GLY A O    1 
ATOM   346  H H    . GLY A 1 62  ? -51.681 27.087 17.582  1.00 30.71 ? 28  GLY A H    1 
ATOM   347  H HA2  . GLY A 1 62  ? -53.433 25.409 16.862  1.00 30.56 ? 28  GLY A HA2  1 
ATOM   348  H HA3  . GLY A 1 62  ? -54.257 26.504 17.646  1.00 30.56 ? 28  GLY A HA3  1 
ATOM   349  N N    . LEU A 1 63  ? -54.590 27.195 15.217  1.00 22.52 ? 29  LEU A N    1 
ATOM   350  C CA   . LEU A 1 63  ? -54.762 28.002 14.021  1.00 22.65 ? 29  LEU A CA   1 
ATOM   351  C C    . LEU A 1 63  ? -55.194 29.418 14.389  1.00 23.55 ? 29  LEU A C    1 
ATOM   352  O O    . LEU A 1 63  ? -55.638 29.693 15.506  1.00 22.52 ? 29  LEU A O    1 
ATOM   353  C CB   . LEU A 1 63  ? -55.785 27.361 13.084  1.00 23.94 ? 29  LEU A CB   1 
ATOM   354  C CG   . LEU A 1 63  ? -55.379 25.995 12.527  1.00 27.20 ? 29  LEU A CG   1 
ATOM   355  C CD1  . LEU A 1 63  ? -56.574 25.282 11.918  1.00 28.29 ? 29  LEU A CD1  1 
ATOM   356  C CD2  . LEU A 1 63  ? -54.264 26.143 11.504  1.00 21.13 ? 29  LEU A CD2  1 
ATOM   357  H H    . LEU A 1 63  ? -55.276 26.721 15.424  1.00 27.06 ? 29  LEU A H    1 
ATOM   358  H HA   . LEU A 1 63  ? -53.918 28.059 13.545  1.00 27.20 ? 29  LEU A HA   1 
ATOM   359  H HB2  . LEU A 1 63  ? -56.616 27.244 13.571  1.00 28.75 ? 29  LEU A HB2  1 
ATOM   360  H HB3  . LEU A 1 63  ? -55.925 27.955 12.330  1.00 28.75 ? 29  LEU A HB3  1 
ATOM   361  H HG   . LEU A 1 63  ? -55.047 25.448 13.256  1.00 32.67 ? 29  LEU A HG   1 
ATOM   362  H HD11 . LEU A 1 63  ? -56.309 24.385 11.660  1.00 33.97 ? 29  LEU A HD11 1 
ATOM   363  H HD12 . LEU A 1 63  ? -57.286 25.240 12.576  1.00 33.97 ? 29  LEU A HD12 1 
ATOM   364  H HD13 . LEU A 1 63  ? -56.873 25.776 11.139  1.00 33.97 ? 29  LEU A HD13 1 
ATOM   365  H HD21 . LEU A 1 63  ? -54.072 25.274 11.118  1.00 25.38 ? 29  LEU A HD21 1 
ATOM   366  H HD22 . LEU A 1 63  ? -54.552 26.756 10.810  1.00 25.38 ? 29  LEU A HD22 1 
ATOM   367  H HD23 . LEU A 1 63  ? -53.474 26.491 11.945  1.00 25.38 ? 29  LEU A HD23 1 
ATOM   368  N N    . MET A 1 64  ? -55.059 30.322 13.424  1.00 20.94 ? 30  MET A N    1 
ATOM   369  C CA   . MET A 1 64  ? -55.317 31.731 13.678  1.00 21.73 ? 30  MET A CA   1 
ATOM   370  C C    . MET A 1 64  ? -56.808 32.001 13.834  1.00 23.15 ? 30  MET A C    1 
ATOM   371  O O    . MET A 1 64  ? -57.654 31.320 13.248  1.00 19.23 ? 30  MET A O    1 
ATOM   372  C CB   . MET A 1 64  ? -54.760 32.585 12.541  1.00 20.50 ? 30  MET A CB   1 
ATOM   373  C CG   . MET A 1 64  ? -53.245 32.628 12.490  1.00 28.65 ? 30  MET A CG   1 
ATOM   374  S SD   . MET A 1 64  ? -52.653 33.358 10.958  1.00 33.14 ? 30  MET A SD   1 
ATOM   375  C CE   . MET A 1 64  ? -52.885 35.087 11.334  1.00 18.66 ? 30  MET A CE   1 
ATOM   376  H H    . MET A 1 64  ? -54.821 30.145 12.617  1.00 25.15 ? 30  MET A H    1 
ATOM   377  H HA   . MET A 1 64  ? -54.867 31.984 14.500  1.00 26.10 ? 30  MET A HA   1 
ATOM   378  H HB2  . MET A 1 64  ? -55.074 32.222 11.698  1.00 24.63 ? 30  MET A HB2  1 
ATOM   379  H HB3  . MET A 1 64  ? -55.078 33.494 12.650  1.00 24.63 ? 30  MET A HB3  1 
ATOM   380  H HG2  . MET A 1 64  ? -52.915 33.162 13.229  1.00 34.41 ? 30  MET A HG2  1 
ATOM   381  H HG3  . MET A 1 64  ? -52.897 31.725 12.552  1.00 34.41 ? 30  MET A HG3  1 
ATOM   382  H HE1  . MET A 1 64  ? -52.733 35.608 10.530  1.00 22.42 ? 30  MET A HE1  1 
ATOM   383  H HE2  . MET A 1 64  ? -53.792 35.222 11.650  1.00 22.42 ? 30  MET A HE2  1 
ATOM   384  H HE3  . MET A 1 64  ? -52.253 35.348 12.022  1.00 22.42 ? 30  MET A HE3  1 
ATOM   385  N N    . THR A 1 65  ? -57.123 33.015 14.635  1.00 21.74 ? 31  THR A N    1 
ATOM   386  C CA   . THR A 1 65  ? -58.489 33.485 14.777  1.00 24.18 ? 31  THR A CA   1 
ATOM   387  C C    . THR A 1 65  ? -58.862 34.386 13.603  1.00 26.92 ? 31  THR A C    1 
ATOM   388  O O    . THR A 1 65  ? -58.002 34.893 12.877  1.00 22.39 ? 31  THR A O    1 
ATOM   389  C CB   . THR A 1 65  ? -58.660 34.250 16.089  1.00 23.80 ? 31  THR A CB   1 
ATOM   390  O OG1  . THR A 1 65  ? -57.856 35.436 16.059  1.00 26.56 ? 31  THR A OG1  1 
ATOM   391  C CG2  . THR A 1 65  ? -58.241 33.391 17.270  1.00 23.70 ? 31  THR A CG2  1 
ATOM   392  H H    . THR A 1 65  ? -56.554 33.450 15.111  1.00 26.12 ? 31  THR A H    1 
ATOM   393  H HA   . THR A 1 65  ? -59.092 32.725 14.788  1.00 29.04 ? 31  THR A HA   1 
ATOM   394  H HB   . THR A 1 65  ? -59.593 34.491 16.202  1.00 28.59 ? 31  THR A HB   1 
ATOM   395  H HG1  . THR A 1 65  ? -57.798 35.763 16.831  1.00 31.89 ? 31  THR A HG1  1 
ATOM   396  H HG21 . THR A 1 65  ? -58.445 33.847 18.101  1.00 28.46 ? 31  THR A HG21 1 
ATOM   397  H HG22 . THR A 1 65  ? -58.715 32.545 17.250  1.00 28.46 ? 31  THR A HG22 1 
ATOM   398  H HG23 . THR A 1 65  ? -57.287 33.218 17.231  1.00 28.46 ? 31  THR A HG23 1 
ATOM   399  N N    . ASP A 1 66  ? -60.173 34.576 13.417  1.00 25.18 ? 32  ASP A N    1 
ATOM   400  C CA   . ASP A 1 66  ? -60.644 35.507 12.396  1.00 26.98 ? 32  ASP A CA   1 
ATOM   401  C C    . ASP A 1 66  ? -59.982 36.867 12.562  1.00 23.41 ? 32  ASP A C    1 
ATOM   402  O O    . ASP A 1 66  ? -59.589 37.506 11.579  1.00 23.51 ? 32  ASP A O    1 
ATOM   403  C CB   . ASP A 1 66  ? -62.166 35.650 12.471  1.00 26.54 ? 32  ASP A CB   1 
ATOM   404  C CG   . ASP A 1 66  ? -62.894 34.370 12.113  1.00 30.08 ? 32  ASP A CG   1 
ATOM   405  O OD1  . ASP A 1 66  ? -62.271 33.474 11.508  1.00 33.17 ? 32  ASP A OD1  1 
ATOM   406  O OD2  . ASP A 1 66  ? -64.096 34.261 12.434  1.00 39.90 ? 32  ASP A OD2  1 
ATOM   407  H H    . ASP A 1 66  ? -60.796 34.185 13.862  1.00 30.24 ? 32  ASP A H    1 
ATOM   408  H HA   . ASP A 1 66  ? -60.419 35.154 11.521  1.00 32.40 ? 32  ASP A HA   1 
ATOM   409  H HB2  . ASP A 1 66  ? -62.416 35.894 13.376  1.00 31.87 ? 32  ASP A HB2  1 
ATOM   410  H HB3  . ASP A 1 66  ? -62.449 36.340 11.851  1.00 31.87 ? 32  ASP A HB3  1 
ATOM   411  N N    . LYS A 1 67  ? -59.847 37.319 13.808  1.00 21.38 ? 33  LYS A N    1 
ATOM   412  C CA   . LYS A 1 67  ? -59.231 38.612 14.080  1.00 29.24 ? 33  LYS A CA   1 
ATOM   413  C C    . LYS A 1 67  ? -57.758 38.612 13.697  1.00 29.37 ? 33  LYS A C    1 
ATOM   414  O O    . LYS A 1 67  ? -57.273 39.562 13.070  1.00 24.73 ? 33  LYS A O    1 
ATOM   415  C CB   . LYS A 1 67  ? -59.414 38.948 15.559  1.00 34.98 ? 33  LYS A CB   1 
ATOM   416  C CG   . LYS A 1 67  ? -58.746 40.232 16.027  1.00 40.90 ? 33  LYS A CG   1 
ATOM   417  C CD   . LYS A 1 67  ? -59.374 40.799 17.315  1.00 49.43 ? 33  LYS A CD   1 
ATOM   418  C CE   . LYS A 1 67  ? -59.796 39.735 18.341  1.00 51.44 ? 33  LYS A CE   1 
ATOM   419  N NZ   . LYS A 1 67  ? -61.006 40.157 19.101  1.00 54.97 ? 33  LYS A NZ   1 
ATOM   420  H H    . LYS A 1 67  ? -60.103 36.896 14.512  1.00 25.68 ? 33  LYS A H    1 
ATOM   421  H HA   . LYS A 1 67  ? -59.668 39.299 13.554  1.00 35.11 ? 33  LYS A HA   1 
ATOM   422  H HB2  . LYS A 1 67  ? -60.363 39.035 15.737  1.00 42.00 ? 33  LYS A HB2  1 
ATOM   423  H HB3  . LYS A 1 67  ? -59.043 38.222 16.085  1.00 42.00 ? 33  LYS A HB3  1 
ATOM   424  H HG2  . LYS A 1 67  ? -57.809 40.055 16.204  1.00 49.11 ? 33  LYS A HG2  1 
ATOM   425  H HG3  . LYS A 1 67  ? -58.831 40.904 15.332  1.00 49.11 ? 33  LYS A HG3  1 
ATOM   426  H HD2  . LYS A 1 67  ? -58.727 41.379 17.746  1.00 59.34 ? 33  LYS A HD2  1 
ATOM   427  H HD3  . LYS A 1 67  ? -60.166 41.305 17.076  1.00 59.34 ? 33  LYS A HD3  1 
ATOM   428  H HE2  . LYS A 1 67  ? -60.000 38.907 17.879  1.00 61.75 ? 33  LYS A HE2  1 
ATOM   429  H HE3  . LYS A 1 67  ? -59.074 39.593 18.972  1.00 61.75 ? 33  LYS A HE3  1 
ATOM   430  H HZ1  . LYS A 1 67  ? -61.234 39.525 19.685  1.00 65.99 ? 33  LYS A HZ1  1 
ATOM   431  H HZ2  . LYS A 1 67  ? -60.840 40.912 19.542  1.00 65.99 ? 33  LYS A HZ2  1 
ATOM   432  H HZ3  . LYS A 1 67  ? -61.685 40.292 18.542  1.00 65.99 ? 33  LYS A HZ3  1 
ATOM   433  N N    . GLU A 1 68  ? -57.030 37.554 14.059  1.00 28.27 ? 34  GLU A N    1 
ATOM   434  C CA   . GLU A 1 68  ? -55.621 37.473 13.690  1.00 22.89 ? 34  GLU A CA   1 
ATOM   435  C C    . GLU A 1 68  ? -55.458 37.415 12.177  1.00 22.47 ? 34  GLU A C    1 
ATOM   436  O O    . GLU A 1 68  ? -54.545 38.034 11.619  1.00 29.24 ? 34  GLU A O    1 
ATOM   437  C CB   . GLU A 1 68  ? -54.981 36.257 14.359  1.00 24.42 ? 34  GLU A CB   1 
ATOM   438  C CG   . GLU A 1 68  ? -54.896 36.381 15.877  1.00 21.62 ? 34  GLU A CG   1 
ATOM   439  C CD   . GLU A 1 68  ? -54.718 35.048 16.576  1.00 23.02 ? 34  GLU A CD   1 
ATOM   440  O OE1  . GLU A 1 68  ? -54.881 33.998 15.922  1.00 20.76 ? 34  GLU A OE1  1 
ATOM   441  O OE2  . GLU A 1 68  ? -54.410 35.052 17.787  1.00 22.54 ? 34  GLU A OE2  1 
ATOM   442  H H    . GLU A 1 68  ? -57.324 36.883 14.510  1.00 33.95 ? 34  GLU A H    1 
ATOM   443  H HA   . GLU A 1 68  ? -55.159 38.264 14.008  1.00 27.49 ? 34  GLU A HA   1 
ATOM   444  H HB2  . GLU A 1 68  ? -55.509 35.470 14.153  1.00 29.34 ? 34  GLU A HB2  1 
ATOM   445  H HB3  . GLU A 1 68  ? -54.079 36.150 14.017  1.00 29.34 ? 34  GLU A HB3  1 
ATOM   446  H HG2  . GLU A 1 68  ? -54.138 36.941 16.105  1.00 25.97 ? 34  GLU A HG2  1 
ATOM   447  H HG3  . GLU A 1 68  ? -55.716 36.783 16.206  1.00 25.97 ? 34  GLU A HG3  1 
ATOM   448  N N    . LEU A 1 69  ? -56.343 36.686 11.493  1.00 16.77 ? 35  LEU A N    1 
ATOM   449  C CA   . LEU A 1 69  ? -56.297 36.645 10.035  1.00 20.96 ? 35  LEU A CA   1 
ATOM   450  C C    . LEU A 1 69  ? -56.597 38.011 9.432   1.00 24.21 ? 35  LEU A C    1 
ATOM   451  O O    . LEU A 1 69  ? -55.961 38.416 8.452   1.00 22.77 ? 35  LEU A O    1 
ATOM   452  C CB   . LEU A 1 69  ? -57.283 35.605 9.509   1.00 21.77 ? 35  LEU A CB   1 
ATOM   453  C CG   . LEU A 1 69  ? -56.869 34.147 9.708   1.00 24.88 ? 35  LEU A CG   1 
ATOM   454  C CD1  . LEU A 1 69  ? -58.069 33.224 9.544   1.00 26.50 ? 35  LEU A CD1  1 
ATOM   455  C CD2  . LEU A 1 69  ? -55.761 33.775 8.734   1.00 26.54 ? 35  LEU A CD2  1 
ATOM   456  H H    . LEU A 1 69  ? -56.970 36.214 11.845  1.00 20.15 ? 35  LEU A H    1 
ATOM   457  H HA   . LEU A 1 69  ? -55.404 36.383 9.761   1.00 25.17 ? 35  LEU A HA   1 
ATOM   458  H HB2  . LEU A 1 69  ? -58.130 35.730 9.965   1.00 26.15 ? 35  LEU A HB2  1 
ATOM   459  H HB3  . LEU A 1 69  ? -57.395 35.746 8.556   1.00 26.15 ? 35  LEU A HB3  1 
ATOM   460  H HG   . LEU A 1 69  ? -56.527 34.030 10.608  1.00 29.89 ? 35  LEU A HG   1 
ATOM   461  H HD11 . LEU A 1 69  ? -57.792 32.312 9.721   1.00 31.83 ? 35  LEU A HD11 1 
ATOM   462  H HD12 . LEU A 1 69  ? -58.758 33.488 10.173  1.00 31.83 ? 35  LEU A HD12 1 
ATOM   463  H HD13 . LEU A 1 69  ? -58.403 33.299 8.637   1.00 31.83 ? 35  LEU A HD13 1 
ATOM   464  H HD21 . LEU A 1 69  ? -55.562 32.831 8.828   1.00 31.88 ? 35  LEU A HD21 1 
ATOM   465  H HD22 . LEU A 1 69  ? -56.060 33.962 7.830   1.00 31.88 ? 35  LEU A HD22 1 
ATOM   466  H HD23 . LEU A 1 69  ? -54.972 34.301 8.938   1.00 31.88 ? 35  LEU A HD23 1 
ATOM   467  N N    . ASP A 1 70  ? -57.566 38.735 9.997   1.00 26.46 ? 36  ASP A N    1 
ATOM   468  C CA   . ASP A 1 70  ? -57.885 40.063 9.486   1.00 28.31 ? 36  ASP A CA   1 
ATOM   469  C C    . ASP A 1 70  ? -56.676 40.985 9.582   1.00 23.24 ? 36  ASP A C    1 
ATOM   470  O O    . ASP A 1 70  ? -56.330 41.679 8.621   1.00 28.77 ? 36  ASP A O    1 
ATOM   471  C CB   . ASP A 1 70  ? -59.074 40.648 10.250  1.00 25.89 ? 36  ASP A CB   1 
ATOM   472  C CG   . ASP A 1 70  ? -59.440 42.043 9.780   1.00 29.67 ? 36  ASP A CG   1 
ATOM   473  O OD2  . ASP A 1 70  ? -59.090 43.017 10.482  1.00 35.91 ? 36  ASP A OD2  1 
ATOM   474  H H    . ASP A 1 70  ? -58.045 38.482 10.666  1.00 31.78 ? 36  ASP A H    1 
ATOM   475  H HA   . ASP A 1 70  ? -58.138 39.991 8.552   1.00 34.00 ? 36  ASP A HA   1 
ATOM   476  H HB2  . ASP A 1 70  ? -59.846 40.075 10.122  1.00 31.10 ? 36  ASP A HB2  1 
ATOM   477  H HB3  . ASP A 1 70  ? -58.851 40.698 11.193  1.00 31.10 ? 36  ASP A HB3  1 
ATOM   478  N N    . PHE A 1 71  ? -56.012 40.994 10.740  1.00 21.19 ? 37  PHE A N    1 
ATOM   479  C CA   . PHE A 1 71  ? -54.833 41.835 10.919  1.00 25.05 ? 37  PHE A CA   1 
ATOM   480  C C    . PHE A 1 71  ? -53.759 41.499 9.893   1.00 27.37 ? 37  PHE A C    1 
ATOM   481  O O    . PHE A 1 71  ? -53.195 42.392 9.249   1.00 25.28 ? 37  PHE A O    1 
ATOM   482  C CB   . PHE A 1 71  ? -54.287 41.665 12.337  1.00 25.23 ? 37  PHE A CB   1 
ATOM   483  C CG   . PHE A 1 71  ? -53.015 42.422 12.592  1.00 26.72 ? 37  PHE A CG   1 
ATOM   484  C CD1  . PHE A 1 71  ? -51.784 41.847 12.325  1.00 25.37 ? 37  PHE A CD1  1 
ATOM   485  C CD2  . PHE A 1 71  ? -53.050 43.708 13.103  1.00 25.44 ? 37  PHE A CD2  1 
ATOM   486  C CE1  . PHE A 1 71  ? -50.612 42.541 12.558  1.00 24.87 ? 37  PHE A CE1  1 
ATOM   487  C CE2  . PHE A 1 71  ? -51.881 44.407 13.339  1.00 30.20 ? 37  PHE A CE2  1 
ATOM   488  C CZ   . PHE A 1 71  ? -50.661 43.821 13.067  1.00 27.02 ? 37  PHE A CZ   1 
ATOM   489  H H    . PHE A 1 71  ? -56.224 40.527 11.430  1.00 25.46 ? 37  PHE A H    1 
ATOM   490  H HA   . PHE A 1 71  ? -55.090 42.762 10.797  1.00 30.08 ? 37  PHE A HA   1 
ATOM   491  H HB2  . PHE A 1 71  ? -54.952 41.982 12.967  1.00 30.31 ? 37  PHE A HB2  1 
ATOM   492  H HB3  . PHE A 1 71  ? -54.106 40.724 12.490  1.00 30.31 ? 37  PHE A HB3  1 
ATOM   493  H HD1  . PHE A 1 71  ? -51.745 40.982 11.984  1.00 30.48 ? 37  PHE A HD1  1 
ATOM   494  H HD2  . PHE A 1 71  ? -53.869 44.107 13.291  1.00 30.56 ? 37  PHE A HD2  1 
ATOM   495  H HE1  . PHE A 1 71  ? -49.792 42.145 12.371  1.00 29.87 ? 37  PHE A HE1  1 
ATOM   496  H HE2  . PHE A 1 71  ? -51.916 45.271 13.681  1.00 36.27 ? 37  PHE A HE2  1 
ATOM   497  H HZ   . PHE A 1 71  ? -49.873 44.290 13.226  1.00 32.45 ? 37  PHE A HZ   1 
ATOM   498  N N    . VAL A 1 72  ? -53.454 40.212 9.733   1.00 23.26 ? 38  VAL A N    1 
ATOM   499  C CA   . VAL A 1 72  ? -52.351 39.815 8.866   1.00 25.17 ? 38  VAL A CA   1 
ATOM   500  C C    . VAL A 1 72  ? -52.690 40.099 7.408   1.00 24.29 ? 38  VAL A C    1 
ATOM   501  O O    . VAL A 1 72  ? -51.906 40.719 6.682   1.00 21.52 ? 38  VAL A O    1 
ATOM   502  C CB   . VAL A 1 72  ? -52.002 38.333 9.095   1.00 24.36 ? 38  VAL A CB   1 
ATOM   503  C CG1  . VAL A 1 72  ? -50.953 37.868 8.100   1.00 27.06 ? 38  VAL A CG1  1 
ATOM   504  C CG2  . VAL A 1 72  ? -51.509 38.130 10.519  1.00 19.80 ? 38  VAL A CG2  1 
ATOM   505  H H    . VAL A 1 72  ? -53.866 39.559 10.112  1.00 27.94 ? 38  VAL A H    1 
ATOM   506  H HA   . VAL A 1 72  ? -51.570 40.344 9.093   1.00 30.23 ? 38  VAL A HA   1 
ATOM   507  H HB   . VAL A 1 72  ? -52.799 37.797 8.962   1.00 29.26 ? 38  VAL A HB   1 
ATOM   508  H HG11 . VAL A 1 72  ? -50.572 37.032 8.411   1.00 32.50 ? 38  VAL A HG11 1 
ATOM   509  H HG12 . VAL A 1 72  ? -51.374 37.738 7.235   1.00 32.50 ? 38  VAL A HG12 1 
ATOM   510  H HG13 . VAL A 1 72  ? -50.260 38.543 8.032   1.00 32.50 ? 38  VAL A HG13 1 
ATOM   511  H HG21 . VAL A 1 72  ? -51.207 37.214 10.621  1.00 23.79 ? 38  VAL A HG21 1 
ATOM   512  H HG22 . VAL A 1 72  ? -50.775 38.741 10.689  1.00 23.79 ? 38  VAL A HG22 1 
ATOM   513  H HG23 . VAL A 1 72  ? -52.237 38.310 11.134  1.00 23.79 ? 38  VAL A HG23 1 
ATOM   514  N N    . THR A 1 73  ? -53.869 39.660 6.959   1.00 22.25 ? 39  THR A N    1 
ATOM   515  C CA   . THR A 1 73  ? -54.248 39.878 5.568   1.00 23.76 ? 39  THR A CA   1 
ATOM   516  C C    . THR A 1 73  ? -54.482 41.354 5.266   1.00 26.05 ? 39  THR A C    1 
ATOM   517  O O    . THR A 1 73  ? -54.328 41.778 4.115   1.00 28.75 ? 39  THR A O    1 
ATOM   518  C CB   . THR A 1 73  ? -55.499 39.067 5.226   1.00 27.46 ? 39  THR A CB   1 
ATOM   519  O OG1  . THR A 1 73  ? -56.573 39.436 6.101   1.00 26.04 ? 39  THR A OG1  1 
ATOM   520  C CG2  . THR A 1 73  ? -55.221 37.580 5.364   1.00 26.73 ? 39  THR A CG2  1 
ATOM   521  H H    . THR A 1 73  ? -54.454 39.243 7.432   1.00 26.73 ? 39  THR A H    1 
ATOM   522  H HA   . THR A 1 73  ? -53.524 39.567 5.002   1.00 28.54 ? 39  THR A HA   1 
ATOM   523  H HB   . THR A 1 73  ? -55.759 39.247 4.309   1.00 32.98 ? 39  THR A HB   1 
ATOM   524  H HG1  . THR A 1 73  ? -56.424 39.147 6.875   1.00 31.27 ? 39  THR A HG1  1 
ATOM   525  H HG21 . THR A 1 73  ? -55.979 37.069 5.040   1.00 32.10 ? 39  THR A HG21 1 
ATOM   526  H HG22 . THR A 1 73  ? -54.436 37.339 4.847   1.00 32.10 ? 39  THR A HG22 1 
ATOM   527  H HG23 . THR A 1 73  ? -55.065 37.356 6.295   1.00 32.10 ? 39  THR A HG23 1 
ATOM   528  N N    . SER A 1 74  ? -54.851 42.149 6.271   1.00 24.76 ? 40  SER A N    1 
ATOM   529  C CA   . SER A 1 74  ? -55.038 43.579 6.057   1.00 24.63 ? 40  SER A CA   1 
ATOM   530  C C    . SER A 1 74  ? -53.722 44.335 5.945   1.00 20.32 ? 40  SER A C    1 
ATOM   531  O O    . SER A 1 74  ? -53.728 45.487 5.499   1.00 27.55 ? 40  SER A O    1 
ATOM   532  C CB   . SER A 1 74  ? -55.869 44.185 7.192   1.00 27.82 ? 40  SER A CB   1 
ATOM   533  O OG   . SER A 1 74  ? -55.098 44.332 8.373   1.00 25.02 ? 40  SER A OG   1 
ATOM   534  H H    . SER A 1 74  ? -54.997 41.885 7.076   1.00 29.74 ? 40  SER A H    1 
ATOM   535  H HA   . SER A 1 74  ? -55.530 43.700 5.230   1.00 29.58 ? 40  SER A HA   1 
ATOM   536  H HB2  . SER A 1 74  ? -56.189 45.058 6.915   1.00 33.41 ? 40  SER A HB2  1 
ATOM   537  H HB3  . SER A 1 74  ? -56.621 43.601 7.378   1.00 33.41 ? 40  SER A HB3  1 
ATOM   538  H HG   . SER A 1 74  ? -54.852 43.578 8.651   1.00 30.05 ? 40  SER A HG   1 
ATOM   539  N N    . HIS A 1 75  ? -52.601 43.720 6.326   1.00 25.38 ? 41  HIS A N    1 
ATOM   540  C CA   . HIS A 1 75  ? -51.319 44.407 6.356   1.00 21.92 ? 41  HIS A CA   1 
ATOM   541  C C    . HIS A 1 75  ? -50.291 43.867 5.370   1.00 24.17 ? 41  HIS A C    1 
ATOM   542  O O    . HIS A 1 75  ? -49.288 44.546 5.127   1.00 23.22 ? 41  HIS A O    1 
ATOM   543  C CB   . HIS A 1 75  ? -50.722 44.345 7.771   1.00 23.48 ? 41  HIS A CB   1 
ATOM   544  C CG   . HIS A 1 75  ? -51.354 45.301 8.733   1.00 26.57 ? 41  HIS A CG   1 
ATOM   545  N ND1  . HIS A 1 75  ? -51.536 46.635 8.442   1.00 29.67 ? 41  HIS A ND1  1 
ATOM   546  C CD2  . HIS A 1 75  ? -51.849 45.116 9.979   1.00 30.11 ? 41  HIS A CD2  1 
ATOM   547  C CE1  . HIS A 1 75  ? -52.116 47.232 9.468   1.00 29.60 ? 41  HIS A CE1  1 
ATOM   548  N NE2  . HIS A 1 75  ? -52.316 46.333 10.415  1.00 26.67 ? 41  HIS A NE2  1 
ATOM   549  H H    . HIS A 1 75  ? -52.562 42.898 6.573   1.00 30.48 ? 41  HIS A H    1 
ATOM   550  H HA   . HIS A 1 75  ? -51.477 45.336 6.126   1.00 26.33 ? 41  HIS A HA   1 
ATOM   551  H HB2  . HIS A 1 75  ? -50.841 43.449 8.121   1.00 28.20 ? 41  HIS A HB2  1 
ATOM   552  H HB3  . HIS A 1 75  ? -49.777 44.558 7.720   1.00 28.20 ? 41  HIS A HB3  1 
ATOM   553  H HD1  . HIS A 1 75  ? -51.309 47.020 7.707   1.00 35.63 ? 41  HIS A HD1  1 
ATOM   554  H HD2  . HIS A 1 75  ? -51.869 44.315 10.452  1.00 36.16 ? 41  HIS A HD2  1 
ATOM   555  H HE1  . HIS A 1 75  ? -52.344 48.132 9.517   1.00 35.55 ? 41  HIS A HE1  1 
ATOM   556  N N    . SER A 1 76  ? -50.499 42.683 4.797   1.00 21.92 ? 42  SER A N    1 
ATOM   557  C CA   . SER A 1 76  ? -49.493 42.106 3.915   1.00 20.30 ? 42  SER A CA   1 
ATOM   558  C C    . SER A 1 76  ? -50.131 41.060 3.015   1.00 19.68 ? 42  SER A C    1 
ATOM   559  O O    . SER A 1 76  ? -51.135 40.440 3.374   1.00 20.35 ? 42  SER A O    1 
ATOM   560  C CB   . SER A 1 76  ? -48.346 41.478 4.715   1.00 22.15 ? 42  SER A CB   1 
ATOM   561  O OG   . SER A 1 76  ? -47.391 40.880 3.857   1.00 22.10 ? 42  SER A OG   1 
ATOM   562  H H    . SER A 1 76  ? -51.204 42.202 4.904   1.00 26.33 ? 42  SER A H    1 
ATOM   563  H HA   . SER A 1 76  ? -49.139 42.808 3.347   1.00 24.39 ? 42  SER A HA   1 
ATOM   564  H HB2  . SER A 1 76  ? -47.911 42.170 5.237   1.00 26.61 ? 42  SER A HB2  1 
ATOM   565  H HB3  . SER A 1 76  ? -48.709 40.798 5.304   1.00 26.61 ? 42  SER A HB3  1 
ATOM   566  H HG   . SER A 1 76  ? -47.062 41.459 3.345   1.00 26.54 ? 42  SER A HG   1 
ATOM   567  N N    . ASN A 1 77  ? -49.525 40.872 1.842   1.00 16.74 ? 43  ASN A N    1 
ATOM   568  C CA   . ASN A 1 77  ? -49.904 39.830 0.899   1.00 20.90 ? 43  ASN A CA   1 
ATOM   569  C C    . ASN A 1 77  ? -48.933 38.657 0.914   1.00 21.79 ? 43  ASN A C    1 
ATOM   570  O O    . ASN A 1 77  ? -49.047 37.760 0.072   1.00 20.02 ? 43  ASN A O    1 
ATOM   571  C CB   . ASN A 1 77  ? -49.976 40.401 -0.519  1.00 23.93 ? 43  ASN A CB   1 
ATOM   572  C CG   . ASN A 1 77  ? -51.111 41.383 -0.699  1.00 24.90 ? 43  ASN A CG   1 
ATOM   573  O OD1  . ASN A 1 77  ? -52.203 41.196 -0.162  1.00 29.65 ? 43  ASN A OD1  1 
ATOM   574  N ND2  . ASN A 1 77  ? -50.859 42.441 -1.462  1.00 24.83 ? 43  ASN A ND2  1 
ATOM   575  H H    . ASN A 1 77  ? -48.870 41.354 1.565   1.00 20.12 ? 43  ASN A H    1 
ATOM   576  H HA   . ASN A 1 77  ? -50.785 39.505 1.143   1.00 25.10 ? 43  ASN A HA   1 
ATOM   577  H HB2  . ASN A 1 77  ? -49.146 40.863 -0.716  1.00 28.75 ? 43  ASN A HB2  1 
ATOM   578  H HB3  . ASN A 1 77  ? -50.108 39.673 -1.146  1.00 28.75 ? 43  ASN A HB3  1 
ATOM   579  H HD21 . ASN A 1 77  ? -51.471 43.030 -1.597  1.00 29.82 ? 43  ASN A HD21 1 
ATOM   580  H HD22 . ASN A 1 77  ? -50.084 42.537 -1.822  1.00 29.82 ? 43  ASN A HD22 1 
ATOM   581  N N    . PHE A 1 78  ? -47.981 38.646 1.844   1.00 15.50 ? 44  PHE A N    1 
ATOM   582  C CA   . PHE A 1 78  ? -46.852 37.720 1.801   1.00 17.01 ? 44  PHE A CA   1 
ATOM   583  C C    . PHE A 1 78  ? -46.617 37.180 3.204   1.00 18.16 ? 44  PHE A C    1 
ATOM   584  O O    . PHE A 1 78  ? -46.141 37.909 4.080   1.00 13.84 ? 44  PHE A O    1 
ATOM   585  C CB   . PHE A 1 78  ? -45.604 38.423 1.267   1.00 17.02 ? 44  PHE A CB   1 
ATOM   586  C CG   . PHE A 1 78  ? -44.441 37.504 1.013   1.00 17.50 ? 44  PHE A CG   1 
ATOM   587  C CD1  . PHE A 1 78  ? -44.637 36.176 0.677   1.00 18.56 ? 44  PHE A CD1  1 
ATOM   588  C CD2  . PHE A 1 78  ? -43.146 37.980 1.106   1.00 17.94 ? 44  PHE A CD2  1 
ATOM   589  C CE1  . PHE A 1 78  ? -43.564 35.343 0.441   1.00 21.09 ? 44  PHE A CE1  1 
ATOM   590  C CE2  . PHE A 1 78  ? -42.070 37.150 0.871   1.00 15.15 ? 44  PHE A CE2  1 
ATOM   591  C CZ   . PHE A 1 78  ? -42.279 35.831 0.539   1.00 14.78 ? 44  PHE A CZ   1 
ATOM   592  H H    . PHE A 1 78  ? -47.967 39.175 2.522   1.00 18.63 ? 44  PHE A H    1 
ATOM   593  H HA   . PHE A 1 78  ? -47.064 36.970 1.224   1.00 20.43 ? 44  PHE A HA   1 
ATOM   594  H HB2  . PHE A 1 78  ? -45.827 38.855 0.427   1.00 20.45 ? 44  PHE A HB2  1 
ATOM   595  H HB3  . PHE A 1 78  ? -45.320 39.086 1.916   1.00 20.45 ? 44  PHE A HB3  1 
ATOM   596  H HD1  . PHE A 1 78  ? -45.502 35.842 0.609   1.00 22.30 ? 44  PHE A HD1  1 
ATOM   597  H HD2  . PHE A 1 78  ? -42.999 38.871 1.329   1.00 21.56 ? 44  PHE A HD2  1 
ATOM   598  H HE1  . PHE A 1 78  ? -43.707 34.452 0.216   1.00 25.33 ? 44  PHE A HE1  1 
ATOM   599  H HE2  . PHE A 1 78  ? -41.204 37.482 0.937   1.00 18.21 ? 44  PHE A HE2  1 
ATOM   600  H HZ   . PHE A 1 78  ? -41.554 35.270 0.382   1.00 17.76 ? 44  PHE A HZ   1 
ATOM   601  N N    . ILE A 1 79  ? -46.938 35.905 3.413   1.00 16.30 ? 45  ILE A N    1 
ATOM   602  C CA   . ILE A 1 79  ? -46.867 35.281 4.728   1.00 16.05 ? 45  ILE A CA   1 
ATOM   603  C C    . ILE A 1 79  ? -46.086 33.982 4.617   1.00 16.54 ? 45  ILE A C    1 
ATOM   604  O O    . ILE A 1 79  ? -46.416 33.119 3.795   1.00 15.75 ? 45  ILE A O    1 
ATOM   605  C CB   . ILE A 1 79  ? -48.268 35.010 5.308   1.00 13.90 ? 45  ILE A CB   1 
ATOM   606  C CG1  . ILE A 1 79  ? -49.054 36.317 5.420   1.00 19.41 ? 45  ILE A CG1  1 
ATOM   607  C CG2  . ILE A 1 79  ? -48.156 34.326 6.666   1.00 19.78 ? 45  ILE A CG2  1 
ATOM   608  C CD1  . ILE A 1 79  ? -50.248 36.384 4.499   1.00 20.40 ? 45  ILE A CD1  1 
ATOM   609  H H    . ILE A 1 79  ? -47.204 35.371 2.794   1.00 19.59 ? 45  ILE A H    1 
ATOM   610  H HA   . ILE A 1 79  ? -46.388 35.872 5.329   1.00 19.28 ? 45  ILE A HA   1 
ATOM   611  H HB   . ILE A 1 79  ? -48.744 34.417 4.706   1.00 16.70 ? 45  ILE A HB   1 
ATOM   612  H HG12 . ILE A 1 79  ? -49.376 36.411 6.331   1.00 23.32 ? 45  ILE A HG12 1 
ATOM   613  H HG13 . ILE A 1 79  ? -48.466 37.056 5.199   1.00 23.32 ? 45  ILE A HG13 1 
ATOM   614  H HG21 . ILE A 1 79  ? -49.034 34.300 7.080   1.00 23.76 ? 45  ILE A HG21 1 
ATOM   615  H HG22 . ILE A 1 79  ? -47.824 33.424 6.539   1.00 23.76 ? 45  ILE A HG22 1 
ATOM   616  H HG23 . ILE A 1 79  ? -47.543 34.829 7.224   1.00 23.76 ? 45  ILE A HG23 1 
ATOM   617  H HD11 . ILE A 1 79  ? -50.620 37.279 4.528   1.00 24.51 ? 45  ILE A HD11 1 
ATOM   618  H HD12 . ILE A 1 79  ? -49.962 36.174 3.597   1.00 24.51 ? 45  ILE A HD12 1 
ATOM   619  H HD13 . ILE A 1 79  ? -50.911 35.740 4.795   1.00 24.51 ? 45  ILE A HD13 1 
ATOM   620  N N    . VAL A 1 80  ? -45.060 33.843 5.447   1.00 16.13 ? 46  VAL A N    1 
ATOM   621  C CA   . VAL A 1 80  ? -44.334 32.591 5.612   1.00 15.29 ? 46  VAL A CA   1 
ATOM   622  C C    . VAL A 1 80  ? -44.774 31.983 6.936   1.00 18.59 ? 46  VAL A C    1 
ATOM   623  O O    . VAL A 1 80  ? -44.601 32.596 7.996   1.00 17.13 ? 46  VAL A O    1 
ATOM   624  C CB   . VAL A 1 80  ? -42.814 32.813 5.582   1.00 18.85 ? 46  VAL A CB   1 
ATOM   625  C CG1  . VAL A 1 80  ? -42.081 31.484 5.667   1.00 18.69 ? 46  VAL A CG1  1 
ATOM   626  C CG2  . VAL A 1 80  ? -42.409 33.574 4.326   1.00 19.80 ? 46  VAL A CG2  1 
ATOM   627  H H    . VAL A 1 80  ? -44.757 34.479 5.940   1.00 19.39 ? 46  VAL A H    1 
ATOM   628  H HA   . VAL A 1 80  ? -44.563 31.981 4.893   1.00 18.37 ? 46  VAL A HA   1 
ATOM   629  H HB   . VAL A 1 80  ? -42.560 33.348 6.350   1.00 22.64 ? 46  VAL A HB   1 
ATOM   630  H HG11 . VAL A 1 80  ? -41.146 31.624 5.449   1.00 22.45 ? 46  VAL A HG11 1 
ATOM   631  H HG12 . VAL A 1 80  ? -42.161 31.136 6.570   1.00 22.45 ? 46  VAL A HG12 1 
ATOM   632  H HG13 . VAL A 1 80  ? -42.478 30.863 5.037   1.00 22.45 ? 46  VAL A HG13 1 
ATOM   633  H HG21 . VAL A 1 80  ? -41.447 33.699 4.330   1.00 23.78 ? 46  VAL A HG21 1 
ATOM   634  H HG22 . VAL A 1 80  ? -42.673 33.060 3.547   1.00 23.78 ? 46  VAL A HG22 1 
ATOM   635  H HG23 . VAL A 1 80  ? -42.855 34.435 4.321   1.00 23.78 ? 46  VAL A HG23 1 
ATOM   636  N N    . LEU A 1 81  ? -45.361 30.792 6.884   1.00 15.59 ? 47  LEU A N    1 
ATOM   637  C CA   . LEU A 1 81  ? -45.777 30.088 8.089   1.00 16.56 ? 47  LEU A CA   1 
ATOM   638  C C    . LEU A 1 81  ? -44.684 29.111 8.497   1.00 17.47 ? 47  LEU A C    1 
ATOM   639  O O    . LEU A 1 81  ? -44.195 28.336 7.668   1.00 18.70 ? 47  LEU A O    1 
ATOM   640  C CB   . LEU A 1 81  ? -47.104 29.362 7.872   1.00 11.80 ? 47  LEU A CB   1 
ATOM   641  C CG   . LEU A 1 81  ? -48.292 30.307 7.669   1.00 19.87 ? 47  LEU A CG   1 
ATOM   642  C CD1  . LEU A 1 81  ? -49.532 29.542 7.234   1.00 14.48 ? 47  LEU A CD1  1 
ATOM   643  C CD2  . LEU A 1 81  ? -48.564 31.111 8.936   1.00 17.68 ? 47  LEU A CD2  1 
ATOM   644  H H    . LEU A 1 81  ? -45.530 30.369 6.155   1.00 18.73 ? 47  LEU A H    1 
ATOM   645  H HA   . LEU A 1 81  ? -45.907 30.721 8.812   1.00 19.89 ? 47  LEU A HA   1 
ATOM   646  H HB2  . LEU A 1 81  ? -47.029 28.804 7.083   1.00 14.19 ? 47  LEU A HB2  1 
ATOM   647  H HB3  . LEU A 1 81  ? -47.290 28.813 8.650   1.00 14.19 ? 47  LEU A HB3  1 
ATOM   648  H HG   . LEU A 1 81  ? -48.073 30.933 6.960   1.00 23.88 ? 47  LEU A HG   1 
ATOM   649  H HD11 . LEU A 1 81  ? -50.291 30.147 7.230   1.00 17.41 ? 47  LEU A HD11 1 
ATOM   650  H HD12 . LEU A 1 81  ? -49.387 29.187 6.343   1.00 17.41 ? 47  LEU A HD12 1 
ATOM   651  H HD13 . LEU A 1 81  ? -49.690 28.817 7.858   1.00 17.41 ? 47  LEU A HD13 1 
ATOM   652  H HD21 . LEU A 1 81  ? -49.422 31.556 8.850   1.00 21.24 ? 47  LEU A HD21 1 
ATOM   653  H HD22 . LEU A 1 81  ? -48.579 30.508 9.695   1.00 21.24 ? 47  LEU A HD22 1 
ATOM   654  H HD23 . LEU A 1 81  ? -47.861 31.769 9.050   1.00 21.24 ? 47  LEU A HD23 1 
ATOM   655  N N    . GLU A 1 82  ? -44.311 29.153 9.772   1.00 19.43 ? 48  GLU A N    1 
ATOM   656  C CA   . GLU A 1 82  ? -43.149 28.442 10.276  1.00 17.14 ? 48  GLU A CA   1 
ATOM   657  C C    . GLU A 1 82  ? -43.514 27.039 10.746  1.00 17.27 ? 48  GLU A C    1 
ATOM   658  O O    . GLU A 1 82  ? -44.683 26.691 10.922  1.00 17.28 ? 48  GLU A O    1 
ATOM   659  C CB   . GLU A 1 82  ? -42.513 29.215 11.432  1.00 18.00 ? 48  GLU A CB   1 
ATOM   660  C CG   . GLU A 1 82  ? -41.363 30.101 11.013  1.00 26.75 ? 48  GLU A CG   1 
ATOM   661  C CD   . GLU A 1 82  ? -40.013 29.415 11.115  1.00 20.02 ? 48  GLU A CD   1 
ATOM   662  O OE1  . GLU A 1 82  ? -39.031 29.952 10.562  1.00 28.96 ? 48  GLU A OE1  1 
ATOM   663  O OE2  . GLU A 1 82  ? -39.930 28.345 11.749  1.00 23.37 ? 48  GLU A OE2  1 
ATOM   664  H H    . GLU A 1 82  ? -44.726 29.600 10.377  1.00 23.35 ? 48  GLU A H    1 
ATOM   665  H HA   . GLU A 1 82  ? -42.507 28.362 9.553   1.00 20.59 ? 48  GLU A HA   1 
ATOM   666  H HB2  . GLU A 1 82  ? -43.189 29.780 11.837  1.00 21.63 ? 48  GLU A HB2  1 
ATOM   667  H HB3  . GLU A 1 82  ? -42.177 28.581 12.083  1.00 21.63 ? 48  GLU A HB3  1 
ATOM   668  H HG2  . GLU A 1 82  ? -41.492 30.369 10.090  1.00 32.13 ? 48  GLU A HG2  1 
ATOM   669  H HG3  . GLU A 1 82  ? -41.344 30.883 11.586  1.00 32.13 ? 48  GLU A HG3  1 
ATOM   670  N N    . LYS A 1 83  ? -42.476 26.231 10.951  1.00 17.43 ? 49  LYS A N    1 
ATOM   671  C CA   . LYS A 1 83  ? -42.639 24.938 11.600  1.00 19.98 ? 49  LYS A CA   1 
ATOM   672  C C    . LYS A 1 83  ? -43.459 25.091 12.874  1.00 16.14 ? 49  LYS A C    1 
ATOM   673  O O    . LYS A 1 83  ? -43.263 26.029 13.651  1.00 16.25 ? 49  LYS A O    1 
ATOM   674  C CB   . LYS A 1 83  ? -41.267 24.341 11.926  1.00 16.97 ? 49  LYS A CB   1 
ATOM   675  C CG   . LYS A 1 83  ? -40.394 25.248 12.791  1.00 15.63 ? 49  LYS A CG   1 
ATOM   676  C CD   . LYS A 1 83  ? -38.997 24.678 12.998  1.00 22.38 ? 49  LYS A CD   1 
ATOM   677  C CE   . LYS A 1 83  ? -38.053 25.719 13.590  1.00 23.95 ? 49  LYS A CE   1 
ATOM   678  N NZ   . LYS A 1 83  ? -37.627 26.736 12.584  1.00 22.08 ? 49  LYS A NZ   1 
ATOM   679  H H    . LYS A 1 83  ? -41.666 26.410 10.723  1.00 20.94 ? 49  LYS A H    1 
ATOM   680  H HA   . LYS A 1 83  ? -43.102 24.329 11.005  1.00 24.00 ? 49  LYS A HA   1 
ATOM   681  H HB2  . LYS A 1 83  ? -41.395 23.507 12.405  1.00 20.39 ? 49  LYS A HB2  1 
ATOM   682  H HB3  . LYS A 1 83  ? -40.793 24.177 11.095  1.00 20.39 ? 49  LYS A HB3  1 
ATOM   683  H HG2  . LYS A 1 83  ? -40.306 26.112 12.358  1.00 18.78 ? 49  LYS A HG2  1 
ATOM   684  H HG3  . LYS A 1 83  ? -40.809 25.354 13.661  1.00 18.78 ? 49  LYS A HG3  1 
ATOM   685  H HD2  . LYS A 1 83  ? -39.044 23.926 13.610  1.00 26.89 ? 49  LYS A HD2  1 
ATOM   686  H HD3  . LYS A 1 83  ? -38.637 24.389 12.145  1.00 26.89 ? 49  LYS A HD3  1 
ATOM   687  H HE2  . LYS A 1 83  ? -38.503 26.181 14.314  1.00 28.76 ? 49  LYS A HE2  1 
ATOM   688  H HE3  . LYS A 1 83  ? -37.258 25.274 13.924  1.00 28.76 ? 49  LYS A HE3  1 
ATOM   689  H HZ1  . LYS A 1 83  ? -37.021 27.281 12.940  1.00 26.52 ? 49  LYS A HZ1  1 
ATOM   690  H HZ2  . LYS A 1 83  ? -37.271 26.332 11.875  1.00 26.52 ? 49  LYS A HZ2  1 
ATOM   691  H HZ3  . LYS A 1 83  ? -38.329 27.216 12.320  1.00 26.52 ? 49  LYS A HZ3  1 
ATOM   692  N N    . GLY A 1 84  ? -44.393 24.166 13.078  1.00 17.30 ? 50  GLY A N    1 
ATOM   693  C CA   . GLY A 1 84  ? -45.210 24.155 14.269  1.00 23.65 ? 50  GLY A CA   1 
ATOM   694  C C    . GLY A 1 84  ? -46.497 24.945 14.182  1.00 20.75 ? 50  GLY A C    1 
ATOM   695  O O    . GLY A 1 84  ? -47.270 24.941 15.149  1.00 18.37 ? 50  GLY A O    1 
ATOM   696  H H    . GLY A 1 84  ? -44.568 23.528 12.528  1.00 20.79 ? 50  GLY A H    1 
ATOM   697  H HA2  . GLY A 1 84  ? -45.444 23.236 14.474  1.00 28.40 ? 50  GLY A HA2  1 
ATOM   698  H HA3  . GLY A 1 84  ? -44.691 24.520 15.002  1.00 28.40 ? 50  GLY A HA3  1 
ATOM   699  N N    . HIS A 1 85  ? -46.760 25.622 13.066  1.00 18.38 ? 51  HIS A N    1 
ATOM   700  C CA   . HIS A 1 85  ? -47.994 26.387 12.956  1.00 17.58 ? 51  HIS A CA   1 
ATOM   701  C C    . HIS A 1 85  ? -49.201 25.460 12.984  1.00 16.36 ? 51  HIS A C    1 
ATOM   702  O O    . HIS A 1 85  ? -49.191 24.378 12.390  1.00 22.36 ? 51  HIS A O    1 
ATOM   703  C CB   . HIS A 1 85  ? -48.019 27.211 11.670  1.00 13.63 ? 51  HIS A CB   1 
ATOM   704  C CG   . HIS A 1 85  ? -49.206 28.119 11.578  1.00 19.39 ? 51  HIS A CG   1 
ATOM   705  N ND1  . HIS A 1 85  ? -49.289 29.303 12.275  1.00 17.72 ? 51  HIS A ND1  1 
ATOM   706  C CD2  . HIS A 1 85  ? -50.379 27.992 10.913  1.00 18.89 ? 51  HIS A CD2  1 
ATOM   707  C CE1  . HIS A 1 85  ? -50.450 29.881 12.026  1.00 18.25 ? 51  HIS A CE1  1 
ATOM   708  N NE2  . HIS A 1 85  ? -51.131 29.105 11.202  1.00 16.10 ? 51  HIS A NE2  1 
ATOM   709  H H    . HIS A 1 85  ? -46.250 25.654 12.375  1.00 22.08 ? 51  HIS A H    1 
ATOM   710  H HA   . HIS A 1 85  ? -48.044 26.998 13.707  1.00 21.12 ? 51  HIS A HA   1 
ATOM   711  H HB2  . HIS A 1 85  ? -47.220 27.760 11.632  1.00 16.39 ? 51  HIS A HB2  1 
ATOM   712  H HB3  . HIS A 1 85  ? -48.044 26.609 10.910  1.00 16.39 ? 51  HIS A HB3  1 
ATOM   713  H HD2  . HIS A 1 85  ? -50.629 27.284 10.364  1.00 22.69 ? 51  HIS A HD2  1 
ATOM   714  H HE1  . HIS A 1 85  ? -50.739 30.695 12.371  1.00 21.93 ? 51  HIS A HE1  1 
ATOM   715  H HE2  . HIS A 1 85  ? -51.918 29.270 10.896  1.00 19.35 ? 51  HIS A HE2  1 
ATOM   716  N N    . GLY A 1 86  ? -50.252 25.896 13.678  1.00 18.45 ? 52  GLY A N    1 
ATOM   717  C CA   . GLY A 1 86  ? -51.510 25.182 13.716  1.00 22.85 ? 52  GLY A CA   1 
ATOM   718  C C    . GLY A 1 86  ? -51.702 24.275 14.913  1.00 25.60 ? 52  GLY A C    1 
ATOM   719  O O    . GLY A 1 86  ? -52.790 23.708 15.068  1.00 23.11 ? 52  GLY A O    1 
ATOM   720  H H    . GLY A 1 86  ? -50.253 26.619 14.143  1.00 22.17 ? 52  GLY A H    1 
ATOM   721  H HA2  . GLY A 1 86  ? -52.233 25.829 13.719  1.00 27.44 ? 52  GLY A HA2  1 
ATOM   722  H HA3  . GLY A 1 86  ? -51.580 24.635 12.918  1.00 27.44 ? 52  GLY A HA3  1 
ATOM   723  N N    . GLY A 1 87  ? -50.688 24.114 15.756  1.00 23.81 ? 53  GLY A N    1 
ATOM   724  C CA   . GLY A 1 87  ? -50.843 23.316 16.955  1.00 26.22 ? 53  GLY A CA   1 
ATOM   725  C C    . GLY A 1 87  ? -50.650 21.830 16.735  1.00 24.90 ? 53  GLY A C    1 
ATOM   726  O O    . GLY A 1 87  ? -49.833 21.418 15.906  1.00 22.18 ? 53  GLY A O    1 
ATOM   727  H H    . GLY A 1 87  ? -49.907 24.458 15.654  1.00 28.60 ? 53  GLY A H    1 
ATOM   728  H HA2  . GLY A 1 87  ? -50.193 23.608 17.614  1.00 31.49 ? 53  GLY A HA2  1 
ATOM   729  H HA3  . GLY A 1 87  ? -51.735 23.452 17.311  1.00 31.49 ? 53  GLY A HA3  1 
ATOM   730  N N    . ASP A 1 88  ? -51.413 21.013 17.462  1.00 22.10 ? 54  ASP A N    1 
ATOM   731  C CA   . ASP A 1 88  ? -51.156 19.579 17.533  1.00 25.77 ? 54  ASP A CA   1 
ATOM   732  C C    . ASP A 1 88  ? -51.607 18.817 16.292  1.00 22.90 ? 54  ASP A C    1 
ATOM   733  O O    . ASP A 1 88  ? -51.369 17.607 16.216  1.00 24.80 ? 54  ASP A O    1 
ATOM   734  C CB   . ASP A 1 88  ? -51.820 18.988 18.784  1.00 30.21 ? 54  ASP A CB   1 
ATOM   735  C CG   . ASP A 1 88  ? -53.332 19.134 18.779  1.00 31.00 ? 54  ASP A CG   1 
ATOM   736  O OD1  . ASP A 1 88  ? -53.901 19.559 17.752  1.00 24.68 ? 54  ASP A OD1  1 
ATOM   737  O OD2  . ASP A 1 88  ? -53.954 18.821 19.816  1.00 31.35 ? 54  ASP A OD2  1 
ATOM   738  H H    . ASP A 1 88  ? -52.090 21.269 17.927  1.00 26.55 ? 54  ASP A H    1 
ATOM   739  H HA   . ASP A 1 88  ? -50.198 19.446 17.613  1.00 30.96 ? 54  ASP A HA   1 
ATOM   740  H HB2  . ASP A 1 88  ? -51.611 18.043 18.834  1.00 36.28 ? 54  ASP A HB2  1 
ATOM   741  H HB3  . ASP A 1 88  ? -51.478 19.446 19.568  1.00 36.28 ? 54  ASP A HB3  1 
ATOM   742  N N    . ILE A 1 89  ? -52.248 19.476 15.323  1.00 26.98 ? 55  ILE A N    1 
ATOM   743  C CA   . ILE A 1 89  ? -52.471 18.842 14.028  1.00 24.72 ? 55  ILE A CA   1 
ATOM   744  C C    . ILE A 1 89  ? -51.194 18.768 13.205  1.00 20.92 ? 55  ILE A C    1 
ATOM   745  O O    . ILE A 1 89  ? -51.191 18.142 12.140  1.00 22.07 ? 55  ILE A O    1 
ATOM   746  C CB   . ILE A 1 89  ? -53.561 19.577 13.220  1.00 23.66 ? 55  ILE A CB   1 
ATOM   747  C CG1  . ILE A 1 89  ? -53.148 21.025 12.940  1.00 24.10 ? 55  ILE A CG1  1 
ATOM   748  C CG2  . ILE A 1 89  ? -54.890 19.526 13.960  1.00 25.69 ? 55  ILE A CG2  1 
ATOM   749  C CD1  . ILE A 1 89  ? -54.256 21.868 12.342  1.00 22.18 ? 55  ILE A CD1  1 
ATOM   750  H H    . ILE A 1 89  ? -52.557 20.275 15.392  1.00 32.41 ? 55  ILE A H    1 
ATOM   751  H HA   . ILE A 1 89  ? -52.789 17.940 14.192  1.00 29.69 ? 55  ILE A HA   1 
ATOM   752  H HB   . ILE A 1 89  ? -53.664 19.127 12.367  1.00 28.42 ? 55  ILE A HB   1 
ATOM   753  H HG12 . ILE A 1 89  ? -52.877 21.440 13.775  1.00 28.95 ? 55  ILE A HG12 1 
ATOM   754  H HG13 . ILE A 1 89  ? -52.406 21.023 12.315  1.00 28.95 ? 55  ILE A HG13 1 
ATOM   755  H HG21 . ILE A 1 89  ? -55.604 19.746 13.342  1.00 30.86 ? 55  ILE A HG21 1 
ATOM   756  H HG22 . ILE A 1 89  ? -55.021 18.632 14.312  1.00 30.86 ? 55  ILE A HG22 1 
ATOM   757  H HG23 . ILE A 1 89  ? -54.871 20.168 14.687  1.00 30.86 ? 55  ILE A HG23 1 
ATOM   758  H HD11 . ILE A 1 89  ? -53.874 22.686 11.987  1.00 26.64 ? 55  ILE A HD11 1 
ATOM   759  H HD12 . ILE A 1 89  ? -54.685 21.367 11.631  1.00 26.64 ? 55  ILE A HD12 1 
ATOM   760  H HD13 . ILE A 1 89  ? -54.902 22.078 13.035  1.00 26.64 ? 55  ILE A HD13 1 
ATOM   761  N N    . ARG A 1 90  ? -50.117 19.399 13.681  1.00 19.07 ? 56  ARG A N    1 
ATOM   762  C CA   . ARG A 1 90  ? -48.798 19.377 13.054  1.00 16.66 ? 56  ARG A CA   1 
ATOM   763  C C    . ARG A 1 90  ? -48.763 20.257 11.809  1.00 16.88 ? 56  ARG A C    1 
ATOM   764  O O    . ARG A 1 90  ? -49.805 20.702 11.318  1.00 21.02 ? 56  ARG A O    1 
ATOM   765  C CB   . ARG A 1 90  ? -48.374 17.940 12.737  1.00 23.63 ? 56  ARG A CB   1 
ATOM   766  C CG   . ARG A 1 90  ? -48.157 17.104 13.995  1.00 26.98 ? 56  ARG A CG   1 
ATOM   767  C CD   . ARG A 1 90  ? -47.485 15.775 13.698  1.00 27.93 ? 56  ARG A CD   1 
ATOM   768  N NE   . ARG A 1 90  ? -47.241 15.006 14.913  1.00 37.55 ? 56  ARG A NE   1 
ATOM   769  H H    . ARG A 1 90  ? -50.126 19.869 14.401  1.00 22.91 ? 56  ARG A H    1 
ATOM   770  H HA   . ARG A 1 90  ? -48.148 19.738 13.676  1.00 20.02 ? 56  ARG A HA   1 
ATOM   771  H HB2  . ARG A 1 90  ? -49.067 17.515 12.208  1.00 28.39 ? 56  ARG A HB2  1 
ATOM   772  H HB3  . ARG A 1 90  ? -47.541 17.958 12.240  1.00 28.39 ? 56  ARG A HB3  1 
ATOM   773  H HG2  . ARG A 1 90  ? -47.592 17.596 14.610  1.00 32.41 ? 56  ARG A HG2  1 
ATOM   774  H HG3  . ARG A 1 90  ? -49.016 16.921 14.407  1.00 32.41 ? 56  ARG A HG3  1 
ATOM   775  H HD2  . ARG A 1 90  ? -48.057 15.251 13.116  1.00 33.54 ? 56  ARG A HD2  1 
ATOM   776  H HD3  . ARG A 1 90  ? -46.632 15.939 13.266  1.00 33.54 ? 56  ARG A HD3  1 
ATOM   777  N N    . THR A 1 91  ? -47.558 20.503 11.290  1.00 17.48 ? 57  THR A N    1 
ATOM   778  C CA   . THR A 1 91  ? -47.335 21.665 10.434  1.00 14.68 ? 57  THR A CA   1 
ATOM   779  C C    . THR A 1 91  ? -48.034 21.531 9.085   1.00 19.24 ? 57  THR A C    1 
ATOM   780  O O    . THR A 1 91  ? -48.585 22.511 8.571   1.00 16.34 ? 57  THR A O    1 
ATOM   781  C CB   . THR A 1 91  ? -45.834 21.881 10.236  1.00 16.80 ? 57  THR A CB   1 
ATOM   782  O OG1  . THR A 1 91  ? -45.201 22.044 11.511  1.00 19.96 ? 57  THR A OG1  1 
ATOM   783  C CG2  . THR A 1 91  ? -45.572 23.117 9.385   1.00 18.93 ? 57  THR A CG2  1 
ATOM   784  H H    . THR A 1 91  ? -46.860 20.017 11.418  1.00 21.00 ? 57  THR A H    1 
ATOM   785  H HA   . THR A 1 91  ? -47.707 22.445 10.876  1.00 17.64 ? 57  THR A HA   1 
ATOM   786  H HB   . THR A 1 91  ? -45.458 21.112 9.781   1.00 20.19 ? 57  THR A HB   1 
ATOM   787  H HG1  . THR A 1 91  ? -45.308 21.353 11.976  1.00 23.97 ? 57  THR A HG1  1 
ATOM   788  H HG21 . THR A 1 91  ? -44.633 23.358 9.431   1.00 22.75 ? 57  THR A HG21 1 
ATOM   789  H HG22 . THR A 1 91  ? -45.806 22.939 8.461   1.00 22.75 ? 57  THR A HG22 1 
ATOM   790  H HG23 . THR A 1 91  ? -46.104 23.861 9.708   1.00 22.75 ? 57  THR A HG23 1 
ATOM   791  N N    . GLU A 1 92  ? -48.010 20.339 8.486   1.00 16.86 ? 58  GLU A N    1 
ATOM   792  C CA   . GLU A 1 92  ? -48.577 20.184 7.148   1.00 18.35 ? 58  GLU A CA   1 
ATOM   793  C C    . GLU A 1 92  ? -50.051 20.571 7.130   1.00 21.15 ? 58  GLU A C    1 
ATOM   794  O O    . GLU A 1 92  ? -50.476 21.407 6.324   1.00 21.45 ? 58  GLU A O    1 
ATOM   795  C CB   . GLU A 1 92  ? -48.390 18.750 6.658   1.00 18.19 ? 58  GLU A CB   1 
ATOM   796  C CG   . GLU A 1 92  ? -46.936 18.350 6.475   1.00 21.74 ? 58  GLU A CG   1 
ATOM   797  C CD   . GLU A 1 92  ? -46.424 17.474 7.599   1.00 21.97 ? 58  GLU A CD   1 
ATOM   798  O OE1  . GLU A 1 92  ? -46.830 17.689 8.763   1.00 21.81 ? 58  GLU A OE1  1 
ATOM   799  O OE2  . GLU A 1 92  ? -45.610 16.573 7.316   1.00 17.38 ? 58  GLU A OE2  1 
ATOM   800  H H    . GLU A 1 92  ? -47.679 19.621 8.824   1.00 20.26 ? 58  GLU A H    1 
ATOM   801  H HA   . GLU A 1 92  ? -48.102 20.772 6.540   1.00 22.05 ? 58  GLU A HA   1 
ATOM   802  H HB2  . GLU A 1 92  ? -48.784 18.145 7.306   1.00 21.85 ? 58  GLU A HB2  1 
ATOM   803  H HB3  . GLU A 1 92  ? -48.834 18.653 5.801   1.00 21.85 ? 58  GLU A HB3  1 
ATOM   804  H HG2  . GLU A 1 92  ? -46.846 17.856 5.646   1.00 26.12 ? 58  GLU A HG2  1 
ATOM   805  H HG3  . GLU A 1 92  ? -46.390 19.151 6.446   1.00 26.12 ? 58  GLU A HG3  1 
ATOM   806  N N    . LYS A 1 93  ? -50.849 19.972 8.016   1.00 14.79 ? 59  LYS A N    1 
ATOM   807  C CA   . LYS A 1 93  ? -52.264 20.321 8.080   1.00 16.35 ? 59  LYS A CA   1 
ATOM   808  C C    . LYS A 1 93  ? -52.453 21.747 8.578   1.00 17.95 ? 59  LYS A C    1 
ATOM   809  O O    . LYS A 1 93  ? -53.365 22.453 8.132   1.00 19.38 ? 59  LYS A O    1 
ATOM   810  C CB   . LYS A 1 93  ? -53.006 19.334 8.981   1.00 20.92 ? 59  LYS A CB   1 
ATOM   811  H H    . LYS A 1 93  ? -50.600 19.372 8.579   1.00 17.77 ? 59  LYS A H    1 
ATOM   812  H HA   . LYS A 1 93  ? -52.645 20.258 7.190   1.00 19.64 ? 59  LYS A HA   1 
ATOM   813  N N    . GLY A 1 94  ? -51.597 22.191 9.500   1.00 15.31 ? 60  GLY A N    1 
ATOM   814  C CA   . GLY A 1 94  ? -51.717 23.548 10.007  1.00 18.22 ? 60  GLY A CA   1 
ATOM   815  C C    . GLY A 1 94  ? -51.536 24.589 8.921   1.00 18.90 ? 60  GLY A C    1 
ATOM   816  O O    . GLY A 1 94  ? -52.346 25.509 8.780   1.00 17.77 ? 60  GLY A O    1 
ATOM   817  H H    . GLY A 1 94  ? -50.953 21.733 9.839   1.00 18.40 ? 60  GLY A H    1 
ATOM   818  H HA2  . GLY A 1 94  ? -52.596 23.667 10.401  1.00 21.90 ? 60  GLY A HA2  1 
ATOM   819  H HA3  . GLY A 1 94  ? -51.043 23.696 10.689  1.00 21.90 ? 60  GLY A HA3  1 
ATOM   820  N N    . ILE A 1 95  ? -50.472 24.451 8.129   1.00 17.10 ? 61  ILE A N    1 
ATOM   821  C CA   . ILE A 1 95  ? -50.201 25.427 7.079   1.00 18.28 ? 61  ILE A CA   1 
ATOM   822  C C    . ILE A 1 95  ? -51.219 25.297 5.953   1.00 16.52 ? 61  ILE A C    1 
ATOM   823  O O    . ILE A 1 95  ? -51.654 26.300 5.375   1.00 17.09 ? 61  ILE A O    1 
ATOM   824  C CB   . ILE A 1 95  ? -48.756 25.267 6.573   1.00 16.72 ? 61  ILE A CB   1 
ATOM   825  C CG1  . ILE A 1 95  ? -47.780 25.806 7.624   1.00 15.48 ? 61  ILE A CG1  1 
ATOM   826  C CG2  . ILE A 1 95  ? -48.564 25.987 5.240   1.00 18.56 ? 61  ILE A CG2  1 
ATOM   827  C CD1  . ILE A 1 95  ? -46.318 25.582 7.299   1.00 20.13 ? 61  ILE A CD1  1 
ATOM   828  H H    . ILE A 1 95  ? -49.901 23.810 8.178   1.00 20.55 ? 61  ILE A H    1 
ATOM   829  H HA   . ILE A 1 95  ? -50.290 26.319 7.451   1.00 21.96 ? 61  ILE A HA   1 
ATOM   830  H HB   . ILE A 1 95  ? -48.579 24.324 6.431   1.00 20.09 ? 61  ILE A HB   1 
ATOM   831  H HG12 . ILE A 1 95  ? -47.917 26.762 7.711   1.00 18.60 ? 61  ILE A HG12 1 
ATOM   832  H HG13 . ILE A 1 95  ? -47.962 25.366 8.469   1.00 18.60 ? 61  ILE A HG13 1 
ATOM   833  H HG21 . ILE A 1 95  ? -47.619 26.001 5.022   1.00 22.30 ? 61  ILE A HG21 1 
ATOM   834  H HG22 . ILE A 1 95  ? -49.056 25.513 4.551   1.00 22.30 ? 61  ILE A HG22 1 
ATOM   835  H HG23 . ILE A 1 95  ? -48.899 26.894 5.320   1.00 22.30 ? 61  ILE A HG23 1 
ATOM   836  H HD11 . ILE A 1 95  ? -45.795 25.680 8.110   1.00 24.18 ? 61  ILE A HD11 1 
ATOM   837  H HD12 . ILE A 1 95  ? -46.208 24.687 6.940   1.00 24.18 ? 61  ILE A HD12 1 
ATOM   838  H HD13 . ILE A 1 95  ? -46.037 26.238 6.642   1.00 24.18 ? 61  ILE A HD13 1 
ATOM   839  N N    . ASP A 1 96  ? -51.623 24.067 5.627   1.00 19.96 ? 62  ASP A N    1 
ATOM   840  C CA   . ASP A 1 96  ? -52.618 23.872 4.577   1.00 18.23 ? 62  ASP A CA   1 
ATOM   841  C C    . ASP A 1 96  ? -53.945 24.519 4.957   1.00 21.23 ? 62  ASP A C    1 
ATOM   842  O O    . ASP A 1 96  ? -54.564 25.219 4.148   1.00 19.61 ? 62  ASP A O    1 
ATOM   843  C CB   . ASP A 1 96  ? -52.809 22.379 4.303   1.00 15.96 ? 62  ASP A CB   1 
ATOM   844  C CG   . ASP A 1 96  ? -53.315 22.105 2.900   1.00 23.78 ? 62  ASP A CG   1 
ATOM   845  O OD1  . ASP A 1 96  ? -52.672 22.568 1.933   1.00 21.78 ? 62  ASP A OD1  1 
ATOM   846  O OD2  . ASP A 1 96  ? -54.356 21.429 2.763   1.00 28.87 ? 62  ASP A OD2  1 
ATOM   847  H H    . ASP A 1 96  ? -51.340 23.342 5.993   1.00 23.98 ? 62  ASP A H    1 
ATOM   848  H HA   . ASP A 1 96  ? -52.298 24.288 3.762   1.00 21.90 ? 62  ASP A HA   1 
ATOM   849  H HB2  . ASP A 1 96  ? -51.959 21.926 4.411   1.00 19.18 ? 62  ASP A HB2  1 
ATOM   850  H HB3  . ASP A 1 96  ? -53.457 22.023 4.931   1.00 19.18 ? 62  ASP A HB3  1 
ATOM   851  N N    . ASN A 1 97  ? -54.399 24.294 6.191   1.00 23.76 ? 63  ASN A N    1 
ATOM   852  C CA   . ASN A 1 97  ? -55.659 24.883 6.629   1.00 21.13 ? 63  ASN A CA   1 
ATOM   853  C C    . ASN A 1 97  ? -55.556 26.399 6.728   1.00 19.54 ? 63  ASN A C    1 
ATOM   854  O O    . ASN A 1 97  ? -56.496 27.116 6.366   1.00 19.72 ? 63  ASN A O    1 
ATOM   855  C CB   . ASN A 1 97  ? -56.077 24.284 7.971   1.00 19.59 ? 63  ASN A CB   1 
ATOM   856  C CG   . ASN A 1 97  ? -56.439 22.815 7.866   1.00 26.80 ? 63  ASN A CG   1 
ATOM   857  O OD1  . ASN A 1 97  ? -56.758 22.318 6.786   1.00 35.38 ? 63  ASN A OD1  1 
ATOM   858  N ND2  . ASN A 1 97  ? -56.392 22.112 8.990   1.00 29.99 ? 63  ASN A ND2  1 
ATOM   859  H H    . ASN A 1 97  ? -54.002 23.812 6.783   1.00 28.54 ? 63  ASN A H    1 
ATOM   860  H HA   . ASN A 1 97  ? -56.346 24.671 5.978   1.00 25.38 ? 63  ASN A HA   1 
ATOM   861  H HB2  . ASN A 1 97  ? -55.341 24.369 8.598   1.00 23.53 ? 63  ASN A HB2  1 
ATOM   862  H HB3  . ASN A 1 97  ? -56.853 24.762 8.304   1.00 23.53 ? 63  ASN A HB3  1 
ATOM   863  H HD21 . ASN A 1 97  ? -56.589 21.275 8.983   1.00 36.02 ? 63  ASN A HD21 1 
ATOM   864  H HD22 . ASN A 1 97  ? -56.165 22.494 9.727   1.00 36.02 ? 63  ASN A HD22 1 
ATOM   865  N N    . GLU A 1 98  ? -54.422 26.910 7.214   1.00 18.61 ? 64  GLU A N    1 
ATOM   866  C CA   . GLU A 1 98  ? -54.272 28.355 7.336   1.00 22.52 ? 64  GLU A CA   1 
ATOM   867  C C    . GLU A 1 98  ? -54.153 29.024 5.975   1.00 18.78 ? 64  GLU A C    1 
ATOM   868  O O    . GLU A 1 98  ? -54.633 30.149 5.796   1.00 21.12 ? 64  GLU A O    1 
ATOM   869  C CB   . GLU A 1 98  ? -53.054 28.693 8.191   1.00 17.02 ? 64  GLU A CB   1 
ATOM   870  C CG   . GLU A 1 98  ? -53.123 30.081 8.794   1.00 16.42 ? 64  GLU A CG   1 
ATOM   871  C CD   . GLU A 1 98  ? -54.095 30.148 9.953   1.00 20.25 ? 64  GLU A CD   1 
ATOM   872  O OE1  . GLU A 1 98  ? -53.722 29.714 11.064  1.00 18.19 ? 64  GLU A OE1  1 
ATOM   873  O OE2  . GLU A 1 98  ? -55.234 30.619 9.750   1.00 24.66 ? 64  GLU A OE2  1 
ATOM   874  H H    . GLU A 1 98  ? -53.743 26.450 7.473   1.00 22.36 ? 64  GLU A H    1 
ATOM   875  H HA   . GLU A 1 98  ? -55.058 28.707 7.782   1.00 27.05 ? 64  GLU A HA   1 
ATOM   876  H HB2  . GLU A 1 98  ? -52.992 28.053 8.918   1.00 20.45 ? 64  GLU A HB2  1 
ATOM   877  H HB3  . GLU A 1 98  ? -52.258 28.646 7.638   1.00 20.45 ? 64  GLU A HB3  1 
ATOM   878  H HG2  . GLU A 1 98  ? -52.245 30.331 9.121   1.00 19.73 ? 64  GLU A HG2  1 
ATOM   879  H HG3  . GLU A 1 98  ? -53.416 30.709 8.116   1.00 19.73 ? 64  GLU A HG3  1 
ATOM   880  N N    . ALA A 1 99  ? -53.517 28.360 5.009   1.00 17.39 ? 65  ALA A N    1 
ATOM   881  C CA   . ALA A 1 99  ? -53.448 28.910 3.660   1.00 22.38 ? 65  ALA A CA   1 
ATOM   882  C C    . ALA A 1 99  ? -54.846 29.149 3.102   1.00 23.40 ? 65  ALA A C    1 
ATOM   883  O O    . ALA A 1 99  ? -55.144 30.232 2.586   1.00 23.03 ? 65  ALA A O    1 
ATOM   884  C CB   . ALA A 1 99  ? -52.653 27.971 2.754   1.00 19.01 ? 65  ALA A CB   1 
ATOM   885  H H    . ALA A 1 99  ? -53.123 27.602 5.109   1.00 20.90 ? 65  ALA A H    1 
ATOM   886  H HA   . ALA A 1 99  ? -52.984 29.762 3.687   1.00 26.88 ? 65  ALA A HA   1 
ATOM   887  H HB1  . ALA A 1 99  ? -52.613 28.351 1.862   1.00 22.84 ? 65  ALA A HB1  1 
ATOM   888  H HB2  . ALA A 1 99  ? -51.757 27.871 3.111   1.00 22.84 ? 65  ALA A HB2  1 
ATOM   889  H HB3  . ALA A 1 99  ? -53.096 27.108 2.726   1.00 22.84 ? 65  ALA A HB3  1 
ATOM   890  N N    . GLN A 1 100 ? -55.720 28.142 3.198   1.00 24.20 ? 66  GLN A N    1 
ATOM   891  C CA   . GLN A 1 100 ? -57.114 28.319 2.801   1.00 23.84 ? 66  GLN A CA   1 
ATOM   892  C C    . GLN A 1 100 ? -57.727 29.531 3.485   1.00 24.31 ? 66  GLN A C    1 
ATOM   893  O O    . GLN A 1 100 ? -58.313 30.404 2.833   1.00 23.49 ? 66  GLN A O    1 
ATOM   894  C CB   . GLN A 1 100 ? -57.928 27.072 3.152   1.00 27.00 ? 66  GLN A CB   1 
ATOM   895  C CG   . GLN A 1 100 ? -57.498 25.812 2.451   1.00 33.47 ? 66  GLN A CG   1 
ATOM   896  C CD   . GLN A 1 100 ? -58.357 24.624 2.833   1.00 35.84 ? 66  GLN A CD   1 
ATOM   897  O OE1  . GLN A 1 100 ? -59.569 24.628 2.617   1.00 35.54 ? 66  GLN A OE1  1 
ATOM   898  N NE2  . GLN A 1 100 ? -57.736 23.602 3.411   1.00 37.03 ? 66  GLN A NE2  1 
ATOM   899  H H    . GLN A 1 100 ? -55.530 27.355 3.488   1.00 29.07 ? 66  GLN A H    1 
ATOM   900  H HA   . GLN A 1 100 ? -57.141 28.448 1.840   1.00 28.63 ? 66  GLN A HA   1 
ATOM   901  H HB2  . GLN A 1 100 ? -57.852 26.915 4.106   1.00 32.43 ? 66  GLN A HB2  1 
ATOM   902  H HB3  . GLN A 1 100 ? -58.854 27.234 2.915   1.00 32.43 ? 66  GLN A HB3  1 
ATOM   903  H HG2  . GLN A 1 100 ? -57.569 25.941 1.492   1.00 40.19 ? 66  GLN A HG2  1 
ATOM   904  H HG3  . GLN A 1 100 ? -56.580 25.611 2.692   1.00 40.19 ? 66  GLN A HG3  1 
ATOM   905  H HE21 . GLN A 1 100 ? -56.888 23.638 3.550   1.00 44.46 ? 66  GLN A HE21 1 
ATOM   906  H HE22 . GLN A 1 100 ? -58.181 22.905 3.646   1.00 44.46 ? 66  GLN A HE22 1 
ATOM   907  N N    . ARG A 1 101 ? -57.616 29.584 4.814   1.00 23.05 ? 67  ARG A N    1 
ATOM   908  C CA   . ARG A 1 101 ? -58.255 30.650 5.575   1.00 21.23 ? 67  ARG A CA   1 
ATOM   909  C C    . ARG A 1 101 ? -57.706 32.013 5.179   1.00 26.19 ? 67  ARG A C    1 
ATOM   910  O O    . ARG A 1 101 ? -58.461 32.987 5.071   1.00 26.13 ? 67  ARG A O    1 
ATOM   911  C CB   . ARG A 1 101 ? -58.057 30.402 7.069   1.00 22.35 ? 67  ARG A CB   1 
ATOM   912  C CG   . ARG A 1 101 ? -58.757 29.153 7.585   1.00 24.29 ? 67  ARG A CG   1 
ATOM   913  C CD   . ARG A 1 101 ? -60.067 29.500 8.268   1.00 29.38 ? 67  ARG A CD   1 
ATOM   914  N NE   . ARG A 1 101 ? -59.845 30.183 9.536   1.00 29.57 ? 67  ARG A NE   1 
ATOM   915  C CZ   . ARG A 1 101 ? -60.708 31.011 10.109  1.00 35.00 ? 67  ARG A CZ   1 
ATOM   916  N NH1  . ARG A 1 101 ? -61.879 31.284 9.554   1.00 37.09 ? 67  ARG A NH1  1 
ATOM   917  N NH2  . ARG A 1 101 ? -60.389 31.581 11.268  1.00 28.61 ? 67  ARG A NH2  1 
ATOM   918  H H    . ARG A 1 101 ? -57.179 29.019 5.292   1.00 27.68 ? 67  ARG A H    1 
ATOM   919  H HA   . ARG A 1 101 ? -59.207 30.647 5.390   1.00 25.50 ? 67  ARG A HA   1 
ATOM   920  H HB2  . ARG A 1 101 ? -57.108 30.303 7.246   1.00 26.84 ? 67  ARG A HB2  1 
ATOM   921  H HB3  . ARG A 1 101 ? -58.408 31.161 7.560   1.00 26.84 ? 67  ARG A HB3  1 
ATOM   922  H HG2  . ARG A 1 101 ? -58.947 28.560 6.841   1.00 29.17 ? 67  ARG A HG2  1 
ATOM   923  H HG3  . ARG A 1 101 ? -58.185 28.705 8.228   1.00 29.17 ? 67  ARG A HG3  1 
ATOM   924  H HD2  . ARG A 1 101 ? -60.584 30.085 7.692   1.00 35.29 ? 67  ARG A HD2  1 
ATOM   925  H HD3  . ARG A 1 101 ? -60.563 28.685 8.443   1.00 35.29 ? 67  ARG A HD3  1 
ATOM   926  H HE   . ARG A 1 101 ? -59.100 30.039 9.942   1.00 35.51 ? 67  ARG A HE   1 
ATOM   927  H HH11 . ARG A 1 101 ? -62.094 30.921 8.805   1.00 44.53 ? 67  ARG A HH11 1 
ATOM   928  H HH12 . ARG A 1 101 ? -62.424 31.824 9.943   1.00 44.53 ? 67  ARG A HH12 1 
ATOM   929  H HH21 . ARG A 1 101 ? -59.630 31.411 11.636  1.00 34.36 ? 67  ARG A HH21 1 
ATOM   930  H HH22 . ARG A 1 101 ? -60.940 32.119 11.649  1.00 34.36 ? 67  ARG A HH22 1 
ATOM   931  N N    . ILE A 1 102 ? -56.394 32.102 4.957   1.00 21.81 ? 68  ILE A N    1 
ATOM   932  C CA   . ILE A 1 102 ? -55.793 33.373 4.560   1.00 22.21 ? 68  ILE A CA   1 
ATOM   933  C C    . ILE A 1 102 ? -56.354 33.824 3.218   1.00 19.00 ? 68  ILE A C    1 
ATOM   934  O O    . ILE A 1 102 ? -56.811 34.962 3.065   1.00 23.54 ? 68  ILE A O    1 
ATOM   935  C CB   . ILE A 1 102 ? -54.259 33.250 4.514   1.00 23.26 ? 68  ILE A CB   1 
ATOM   936  C CG1  . ILE A 1 102 ? -53.686 33.191 5.931   1.00 18.59 ? 68  ILE A CG1  1 
ATOM   937  C CG2  . ILE A 1 102 ? -53.653 34.419 3.747   1.00 17.05 ? 68  ILE A CG2  1 
ATOM   938  C CD1  . ILE A 1 102 ? -52.259 32.684 5.992   1.00 16.15 ? 68  ILE A CD1  1 
ATOM   939  H H    . ILE A 1 102 ? -55.837 31.450 5.028   1.00 26.20 ? 68  ILE A H    1 
ATOM   940  H HA   . ILE A 1 102 ? -56.021 34.043 5.223   1.00 26.68 ? 68  ILE A HA   1 
ATOM   941  H HB   . ILE A 1 102 ? -54.033 32.427 4.053   1.00 27.93 ? 68  ILE A HB   1 
ATOM   942  H HG12 . ILE A 1 102 ? -53.699 34.084 6.310   1.00 22.33 ? 68  ILE A HG12 1 
ATOM   943  H HG13 . ILE A 1 102 ? -54.235 32.596 6.465   1.00 22.33 ? 68  ILE A HG13 1 
ATOM   944  H HG21 . ILE A 1 102 ? -52.705 34.469 3.945   1.00 20.49 ? 68  ILE A HG21 1 
ATOM   945  H HG22 . ILE A 1 102 ? -53.785 34.276 2.797   1.00 20.49 ? 68  ILE A HG22 1 
ATOM   946  H HG23 . ILE A 1 102 ? -54.093 35.239 4.022   1.00 20.49 ? 68  ILE A HG23 1 
ATOM   947  H HD11 . ILE A 1 102 ? -51.994 32.597 6.921   1.00 19.41 ? 68  ILE A HD11 1 
ATOM   948  H HD12 . ILE A 1 102 ? -52.212 31.820 5.553   1.00 19.41 ? 68  ILE A HD12 1 
ATOM   949  H HD13 . ILE A 1 102 ? -51.679 33.316 5.540   1.00 19.41 ? 68  ILE A HD13 1 
ATOM   950  N N    . LYS A 1 103 ? -56.336 32.933 2.228   1.00 20.79 ? 69  LYS A N    1 
ATOM   951  C CA   . LYS A 1 103 ? -56.751 33.304 0.883   1.00 23.73 ? 69  LYS A CA   1 
ATOM   952  C C    . LYS A 1 103 ? -58.264 33.376 0.737   1.00 27.21 ? 69  LYS A C    1 
ATOM   953  O O    . LYS A 1 103 ? -58.749 33.958 -0.239  1.00 27.15 ? 69  LYS A O    1 
ATOM   954  C CB   . LYS A 1 103 ? -56.155 32.320 -0.124  1.00 26.91 ? 69  LYS A CB   1 
ATOM   955  C CG   . LYS A 1 103 ? -54.647 32.476 -0.257  1.00 24.56 ? 69  LYS A CG   1 
ATOM   956  C CD   . LYS A 1 103 ? -54.071 31.633 -1.377  1.00 28.48 ? 69  LYS A CD   1 
ATOM   957  C CE   . LYS A 1 103 ? -53.164 30.543 -0.832  1.00 21.78 ? 69  LYS A CE   1 
ATOM   958  N NZ   . LYS A 1 103 ? -53.031 29.407 -1.779  1.00 27.26 ? 69  LYS A NZ   1 
ATOM   959  H H    . LYS A 1 103 ? -56.089 32.113 2.311   1.00 24.97 ? 69  LYS A H    1 
ATOM   960  H HA   . LYS A 1 103 ? -56.406 34.185 0.669   1.00 28.51 ? 69  LYS A HA   1 
ATOM   961  H HB2  . LYS A 1 103 ? -56.341 31.414 0.168   1.00 32.32 ? 69  LYS A HB2  1 
ATOM   962  H HB3  . LYS A 1 103 ? -56.553 32.476 -0.995  1.00 32.32 ? 69  LYS A HB3  1 
ATOM   963  H HG2  . LYS A 1 103 ? -54.439 33.405 -0.444  1.00 29.50 ? 69  LYS A HG2  1 
ATOM   964  H HG3  . LYS A 1 103 ? -54.225 32.201 0.572   1.00 29.50 ? 69  LYS A HG3  1 
ATOM   965  H HD2  . LYS A 1 103 ? -54.793 31.213 -1.869  1.00 34.20 ? 69  LYS A HD2  1 
ATOM   966  H HD3  . LYS A 1 103 ? -53.549 32.197 -1.969  1.00 34.20 ? 69  LYS A HD3  1 
ATOM   967  H HE2  . LYS A 1 103 ? -52.280 30.911 -0.674  1.00 26.17 ? 69  LYS A HE2  1 
ATOM   968  H HE3  . LYS A 1 103 ? -53.535 30.204 -0.002  1.00 26.17 ? 69  LYS A HE3  1 
ATOM   969  H HZ1  . LYS A 1 103 ? -52.388 28.855 -1.505  1.00 32.73 ? 69  LYS A HZ1  1 
ATOM   970  H HZ2  . LYS A 1 103 ? -53.797 28.957 -1.825  1.00 32.73 ? 69  LYS A HZ2  1 
ATOM   971  H HZ3  . LYS A 1 103 ? -52.825 29.709 -2.590  1.00 32.73 ? 69  LYS A HZ3  1 
ATOM   972  N N    . ASP A 1 104 ? -59.016 32.803 1.680   1.00 29.87 ? 70  ASP A N    1 
ATOM   973  C CA   . ASP A 1 104 ? -60.450 33.064 1.735   1.00 31.08 ? 70  ASP A CA   1 
ATOM   974  C C    . ASP A 1 104 ? -60.717 34.543 1.981   1.00 32.44 ? 70  ASP A C    1 
ATOM   975  O O    . ASP A 1 104 ? -61.686 35.106 1.458   1.00 30.97 ? 70  ASP A O    1 
ATOM   976  C CB   . ASP A 1 104 ? -61.095 32.218 2.835   1.00 37.40 ? 70  ASP A CB   1 
ATOM   977  C CG   . ASP A 1 104 ? -61.498 30.837 2.353   1.00 41.37 ? 70  ASP A CG   1 
ATOM   978  O OD1  . ASP A 1 104 ? -61.164 30.481 1.203   1.00 39.24 ? 70  ASP A OD1  1 
ATOM   979  O OD2  . ASP A 1 104 ? -62.146 30.104 3.131   1.00 49.87 ? 70  ASP A OD2  1 
ATOM   980  H H    . ASP A 1 104 ? -58.724 32.270 2.288   1.00 35.87 ? 70  ASP A H    1 
ATOM   981  H HA   . ASP A 1 104 ? -60.852 32.813 0.889   1.00 37.32 ? 70  ASP A HA   1 
ATOM   982  H HB2  . ASP A 1 104 ? -60.462 32.109 3.562   1.00 44.91 ? 70  ASP A HB2  1 
ATOM   983  H HB3  . ASP A 1 104 ? -61.892 32.669 3.153   1.00 44.91 ? 70  ASP A HB3  1 
ATOM   984  N N    . ILE A 1 105 ? -59.861 35.187 2.777   1.00 28.16 ? 71  ILE A N    1 
ATOM   985  C CA   . ILE A 1 105 ? -59.999 36.611 3.060   1.00 29.18 ? 71  ILE A CA   1 
ATOM   986  C C    . ILE A 1 105 ? -59.342 37.443 1.970   1.00 29.78 ? 71  ILE A C    1 
ATOM   987  O O    . ILE A 1 105 ? -59.855 38.498 1.583   1.00 26.19 ? 71  ILE A O    1 
ATOM   988  C CB   . ILE A 1 105 ? -59.388 36.931 4.436   1.00 27.15 ? 71  ILE A CB   1 
ATOM   989  C CG1  . ILE A 1 105 ? -60.268 36.395 5.562   1.00 32.58 ? 71  ILE A CG1  1 
ATOM   990  C CG2  . ILE A 1 105 ? -59.172 38.434 4.585   1.00 41.97 ? 71  ILE A CG2  1 
ATOM   991  C CD1  . ILE A 1 105 ? -59.574 36.393 6.903   1.00 30.13 ? 71  ILE A CD1  1 
ATOM   992  H H    . ILE A 1 105 ? -59.188 34.818 3.166   1.00 33.82 ? 71  ILE A H    1 
ATOM   993  H HA   . ILE A 1 105 ? -60.944 36.829 3.080   1.00 35.05 ? 71  ILE A HA   1 
ATOM   994  H HB   . ILE A 1 105 ? -58.527 36.488 4.495   1.00 32.60 ? 71  ILE A HB   1 
ATOM   995  H HG12 . ILE A 1 105 ? -61.060 36.951 5.635   1.00 39.12 ? 71  ILE A HG12 1 
ATOM   996  H HG13 . ILE A 1 105 ? -60.523 35.482 5.355   1.00 39.12 ? 71  ILE A HG13 1 
ATOM   997  H HG21 . ILE A 1 105 ? -59.068 38.646 5.526   1.00 50.39 ? 71  ILE A HG21 1 
ATOM   998  H HG22 . ILE A 1 105 ? -58.372 38.687 4.098   1.00 50.39 ? 71  ILE A HG22 1 
ATOM   999  H HG23 . ILE A 1 105 ? -59.942 38.901 4.224   1.00 50.39 ? 71  ILE A HG23 1 
ATOM   1000 H HD11 . ILE A 1 105 ? -60.027 35.771 7.493   1.00 36.19 ? 71  ILE A HD11 1 
ATOM   1001 H HD12 . ILE A 1 105 ? -58.651 36.121 6.781   1.00 36.19 ? 71  ILE A HD12 1 
ATOM   1002 H HD13 . ILE A 1 105 ? -59.607 37.288 7.277   1.00 36.19 ? 71  ILE A HD13 1 
ATOM   1003 N N    . ASN A 1 106 ? -58.192 36.991 1.473   1.00 27.61 ? 72  ASN A N    1 
ATOM   1004 C CA   . ASN A 1 106 ? -57.360 37.778 0.566   1.00 24.43 ? 72  ASN A CA   1 
ATOM   1005 C C    . ASN A 1 106 ? -56.835 36.844 -0.513  1.00 26.96 ? 72  ASN A C    1 
ATOM   1006 O O    . ASN A 1 106 ? -55.738 36.284 -0.389  1.00 24.15 ? 72  ASN A O    1 
ATOM   1007 C CB   . ASN A 1 106 ? -56.215 38.455 1.322   1.00 27.09 ? 72  ASN A CB   1 
ATOM   1008 C CG   . ASN A 1 106 ? -55.282 39.227 0.411   1.00 29.27 ? 72  ASN A CG   1 
ATOM   1009 O OD1  . ASN A 1 106 ? -55.547 39.392 -0.780  1.00 28.49 ? 72  ASN A OD1  1 
ATOM   1010 N ND2  . ASN A 1 106 ? -54.179 39.710 0.973   1.00 30.63 ? 72  ASN A ND2  1 
ATOM   1011 H H    . ASN A 1 106 ? -57.866 36.216 1.650   1.00 33.16 ? 72  ASN A H    1 
ATOM   1012 H HA   . ASN A 1 106 ? -57.889 38.472 0.142   1.00 29.34 ? 72  ASN A HA   1 
ATOM   1013 H HB2  . ASN A 1 106 ? -56.587 39.076 1.967   1.00 32.54 ? 72  ASN A HB2  1 
ATOM   1014 H HB3  . ASN A 1 106 ? -55.694 37.776 1.778   1.00 32.54 ? 72  ASN A HB3  1 
ATOM   1015 H HD21 . ASN A 1 106 ? -53.615 40.156 0.501   1.00 36.78 ? 72  ASN A HD21 1 
ATOM   1016 H HD22 . ASN A 1 106 ? -54.028 39.576 1.809   1.00 36.78 ? 72  ASN A HD22 1 
ATOM   1017 N N    . PRO A 1 107 ? -57.592 36.656 -1.598  1.00 27.83 ? 73  PRO A N    1 
ATOM   1018 C CA   . PRO A 1 107 ? -57.177 35.680 -2.621  1.00 29.06 ? 73  PRO A CA   1 
ATOM   1019 C C    . PRO A 1 107 ? -55.859 36.025 -3.291  1.00 27.80 ? 73  PRO A C    1 
ATOM   1020 O O    . PRO A 1 107 ? -55.319 35.181 -4.017  1.00 30.28 ? 73  PRO A O    1 
ATOM   1021 C CB   . PRO A 1 107 ? -58.333 35.695 -3.634  1.00 28.05 ? 73  PRO A CB   1 
ATOM   1022 C CG   . PRO A 1 107 ? -59.384 36.607 -3.078  1.00 33.87 ? 73  PRO A CG   1 
ATOM   1023 C CD   . PRO A 1 107 ? -58.763 37.444 -2.018  1.00 28.13 ? 73  PRO A CD   1 
ATOM   1024 H HA   . PRO A 1 107 ? -57.116 34.797 -2.225  1.00 34.90 ? 73  PRO A HA   1 
ATOM   1025 H HB2  . PRO A 1 107 ? -58.011 36.026 -4.487  1.00 33.69 ? 73  PRO A HB2  1 
ATOM   1026 H HB3  . PRO A 1 107 ? -58.683 34.796 -3.738  1.00 33.69 ? 73  PRO A HB3  1 
ATOM   1027 H HG2  . PRO A 1 107 ? -59.726 37.169 -3.791  1.00 40.67 ? 73  PRO A HG2  1 
ATOM   1028 H HG3  . PRO A 1 107 ? -60.102 36.072 -2.704  1.00 40.67 ? 73  PRO A HG3  1 
ATOM   1029 H HD2  . PRO A 1 107 ? -58.490 38.304 -2.375  1.00 33.78 ? 73  PRO A HD2  1 
ATOM   1030 H HD3  . PRO A 1 107 ? -59.376 37.572 -1.277  1.00 33.78 ? 73  PRO A HD3  1 
ATOM   1031 N N    . LYS A 1 108 ? -55.331 37.228 -3.076  1.00 30.46 ? 74  LYS A N    1 
ATOM   1032 C CA   . LYS A 1 108 ? -54.055 37.633 -3.646  1.00 35.79 ? 74  LYS A CA   1 
ATOM   1033 C C    . LYS A 1 108 ? -52.869 37.287 -2.756  1.00 28.36 ? 74  LYS A C    1 
ATOM   1034 O O    . LYS A 1 108 ? -51.724 37.419 -3.199  1.00 28.71 ? 74  LYS A O    1 
ATOM   1035 C CB   . LYS A 1 108 ? -54.059 39.143 -3.913  1.00 36.22 ? 74  LYS A CB   1 
ATOM   1036 C CG   . LYS A 1 108 ? -54.966 39.568 -5.058  1.00 41.71 ? 74  LYS A CG   1 
ATOM   1037 C CD   . LYS A 1 108 ? -54.931 41.076 -5.273  1.00 46.96 ? 74  LYS A CD   1 
ATOM   1038 C CE   . LYS A 1 108 ? -55.487 41.833 -4.074  1.00 51.53 ? 74  LYS A CE   1 
ATOM   1039 N NZ   . LYS A 1 108 ? -56.571 42.778 -4.460  1.00 56.46 ? 74  LYS A NZ   1 
ATOM   1040 H H    . LYS A 1 108 ? -55.702 37.837 -2.595  1.00 36.57 ? 74  LYS A H    1 
ATOM   1041 H HA   . LYS A 1 108 ? -53.934 37.176 -4.493  1.00 42.98 ? 74  LYS A HA   1 
ATOM   1042 H HB2  . LYS A 1 108 ? -54.362 39.599 -3.112  1.00 43.49 ? 74  LYS A HB2  1 
ATOM   1043 H HB3  . LYS A 1 108 ? -53.156 39.421 -4.132  1.00 43.49 ? 74  LYS A HB3  1 
ATOM   1044 H HG2  . LYS A 1 108 ? -54.673 39.137 -5.876  1.00 50.08 ? 74  LYS A HG2  1 
ATOM   1045 H HG3  . LYS A 1 108 ? -55.879 39.310 -4.857  1.00 50.08 ? 74  LYS A HG3  1 
ATOM   1046 H HD2  . LYS A 1 108 ? -54.013 41.358 -5.411  1.00 56.38 ? 74  LYS A HD2  1 
ATOM   1047 H HD3  . LYS A 1 108 ? -55.467 41.301 -6.049  1.00 56.38 ? 74  LYS A HD3  1 
ATOM   1048 H HE2  . LYS A 1 108 ? -55.852 41.198 -3.438  1.00 61.87 ? 74  LYS A HE2  1 
ATOM   1049 H HE3  . LYS A 1 108 ? -54.774 42.343 -3.661  1.00 61.87 ? 74  LYS A HE3  1 
ATOM   1050 H HZ1  . LYS A 1 108 ? -56.803 43.278 -3.761  1.00 67.78 ? 74  LYS A HZ1  1 
ATOM   1051 H HZ2  . LYS A 1 108 ? -56.291 43.311 -5.116  1.00 67.78 ? 74  LYS A HZ2  1 
ATOM   1052 H HZ3  . LYS A 1 108 ? -57.284 42.326 -4.740  1.00 67.78 ? 74  LYS A HZ3  1 
ATOM   1053 N N    . ALA A 1 109 ? -53.110 36.855 -1.521  1.00 25.47 ? 75  ALA A N    1 
ATOM   1054 C CA   . ALA A 1 109 ? -52.018 36.564 -0.606  1.00 25.32 ? 75  ALA A CA   1 
ATOM   1055 C C    . ALA A 1 109 ? -51.209 35.368 -1.092  1.00 21.63 ? 75  ALA A C    1 
ATOM   1056 O O    . ALA A 1 109 ? -51.728 34.454 -1.739  1.00 22.54 ? 75  ALA A O    1 
ATOM   1057 C CB   . ALA A 1 109 ? -52.554 36.291 0.799   1.00 24.58 ? 75  ALA A CB   1 
ATOM   1058 H H    . ALA A 1 109 ? -53.894 36.723 -1.193  1.00 30.60 ? 75  ALA A H    1 
ATOM   1059 H HA   . ALA A 1 109 ? -51.428 37.332 -0.562  1.00 30.41 ? 75  ALA A HA   1 
ATOM   1060 H HB1  . ALA A 1 109 ? -51.811 36.079 1.385   1.00 29.53 ? 75  ALA A HB1  1 
ATOM   1061 H HB2  . ALA A 1 109 ? -53.014 37.082 1.121   1.00 29.53 ? 75  ALA A HB2  1 
ATOM   1062 H HB3  . ALA A 1 109 ? -53.171 35.543 0.762   1.00 29.53 ? 75  ALA A HB3  1 
ATOM   1063 N N    . LYS A 1 110 ? -49.917 35.389 -0.779  1.00 21.42 ? 76  LYS A N    1 
ATOM   1064 C CA   . LYS A 1 110 ? -49.017 34.273 -1.040  1.00 19.31 ? 76  LYS A CA   1 
ATOM   1065 C C    . LYS A 1 110 ? -48.596 33.683 0.299   1.00 19.39 ? 76  LYS A C    1 
ATOM   1066 O O    . LYS A 1 110 ? -47.974 34.371 1.116   1.00 20.16 ? 76  LYS A O    1 
ATOM   1067 C CB   . LYS A 1 110 ? -47.798 34.721 -1.845  1.00 17.84 ? 76  LYS A CB   1 
ATOM   1068 C CG   . LYS A 1 110 ? -48.125 35.225 -3.248  1.00 19.22 ? 76  LYS A CG   1 
ATOM   1069 C CD   . LYS A 1 110 ? -48.863 34.174 -4.069  1.00 22.15 ? 76  LYS A CD   1 
ATOM   1070 C CE   . LYS A 1 110 ? -48.882 34.523 -5.550  1.00 26.00 ? 76  LYS A CE   1 
ATOM   1071 N NZ   . LYS A 1 110 ? -50.214 35.025 -5.987  1.00 32.90 ? 76  LYS A NZ   1 
ATOM   1072 H H    . LYS A 1 110 ? -49.529 36.059 -0.405  1.00 25.73 ? 76  LYS A H    1 
ATOM   1073 H HA   . LYS A 1 110 ? -49.476 33.591 -1.554  1.00 23.20 ? 76  LYS A HA   1 
ATOM   1074 H HB2  . LYS A 1 110 ? -47.359 35.443 -1.368  1.00 21.44 ? 76  LYS A HB2  1 
ATOM   1075 H HB3  . LYS A 1 110 ? -47.193 33.968 -1.937  1.00 21.44 ? 76  LYS A HB3  1 
ATOM   1076 H HG2  . LYS A 1 110 ? -48.689 36.011 -3.183  1.00 23.09 ? 76  LYS A HG2  1 
ATOM   1077 H HG3  . LYS A 1 110 ? -47.301 35.446 -3.709  1.00 23.09 ? 76  LYS A HG3  1 
ATOM   1078 H HD2  . LYS A 1 110 ? -48.421 33.317 -3.965  1.00 26.61 ? 76  LYS A HD2  1 
ATOM   1079 H HD3  . LYS A 1 110 ? -49.781 34.113 -3.760  1.00 26.61 ? 76  LYS A HD3  1 
ATOM   1080 H HE2  . LYS A 1 110 ? -48.226 35.216 -5.724  1.00 31.22 ? 76  LYS A HE2  1 
ATOM   1081 H HE3  . LYS A 1 110 ? -48.673 33.730 -6.068  1.00 31.22 ? 76  LYS A HE3  1 
ATOM   1082 H HZ1  . LYS A 1 110 ? -50.170 35.314 -6.828  1.00 39.50 ? 76  LYS A HZ1  1 
ATOM   1083 H HZ2  . LYS A 1 110 ? -50.817 34.372 -5.938  1.00 39.50 ? 76  LYS A HZ2  1 
ATOM   1084 H HZ3  . LYS A 1 110 ? -50.473 35.697 -5.464  1.00 39.50 ? 76  LYS A HZ3  1 
ATOM   1085 N N    . VAL A 1 111 ? -48.945 32.420 0.523   1.00 17.05 ? 77  VAL A N    1 
ATOM   1086 C CA   . VAL A 1 111 ? -48.677 31.728 1.779   1.00 15.22 ? 77  VAL A CA   1 
ATOM   1087 C C    . VAL A 1 111 ? -47.638 30.653 1.500   1.00 17.76 ? 77  VAL A C    1 
ATOM   1088 O O    . VAL A 1 111 ? -47.840 29.790 0.636   1.00 17.87 ? 77  VAL A O    1 
ATOM   1089 C CB   . VAL A 1 111 ? -49.959 31.128 2.376   1.00 15.95 ? 77  VAL A CB   1 
ATOM   1090 C CG1  . VAL A 1 111 ? -49.671 30.485 3.726   1.00 13.24 ? 77  VAL A CG1  1 
ATOM   1091 C CG2  . VAL A 1 111 ? -51.030 32.205 2.506   1.00 18.23 ? 77  VAL A CG2  1 
ATOM   1092 H H    . VAL A 1 111 ? -49.351 31.930 -0.055  1.00 20.48 ? 77  VAL A H    1 
ATOM   1093 H HA   . VAL A 1 111 ? -48.307 32.351 2.423   1.00 18.29 ? 77  VAL A HA   1 
ATOM   1094 H HB   . VAL A 1 111 ? -50.291 30.436 1.782   1.00 19.17 ? 77  VAL A HB   1 
ATOM   1095 H HG11 . VAL A 1 111 ? -50.495 30.117 4.082   1.00 15.92 ? 77  VAL A HG11 1 
ATOM   1096 H HG12 . VAL A 1 111 ? -49.017 29.779 3.607   1.00 15.92 ? 77  VAL A HG12 1 
ATOM   1097 H HG13 . VAL A 1 111 ? -49.323 31.160 4.329   1.00 15.92 ? 77  VAL A HG13 1 
ATOM   1098 H HG21 . VAL A 1 111 ? -51.806 31.826 2.948   1.00 21.90 ? 77  VAL A HG21 1 
ATOM   1099 H HG22 . VAL A 1 111 ? -50.676 32.940 3.031   1.00 21.90 ? 77  VAL A HG22 1 
ATOM   1100 H HG23 . VAL A 1 111 ? -51.273 32.517 1.621   1.00 21.90 ? 77  VAL A HG23 1 
ATOM   1101 N N    . VAL A 1 112 ? -46.531 30.699 2.237   1.00 14.46 ? 78  VAL A N    1 
ATOM   1102 C CA   . VAL A 1 112 ? -45.364 29.869 1.969   1.00 14.32 ? 78  VAL A CA   1 
ATOM   1103 C C    . VAL A 1 112 ? -45.229 28.821 3.064   1.00 15.67 ? 78  VAL A C    1 
ATOM   1104 O O    . VAL A 1 112 ? -45.416 29.112 4.252   1.00 16.32 ? 78  VAL A O    1 
ATOM   1105 C CB   . VAL A 1 112 ? -44.088 30.728 1.862   1.00 12.52 ? 78  VAL A CB   1 
ATOM   1106 C CG1  . VAL A 1 112 ? -42.854 29.847 1.776   1.00 15.84 ? 78  VAL A CG1  1 
ATOM   1107 C CG2  . VAL A 1 112 ? -44.181 31.652 0.651   1.00 17.81 ? 78  VAL A CG2  1 
ATOM   1108 H H    . VAL A 1 112 ? -46.432 31.218 2.915   1.00 17.38 ? 78  VAL A H    1 
ATOM   1109 H HA   . VAL A 1 112 ? -45.492 29.401 1.130   1.00 17.22 ? 78  VAL A HA   1 
ATOM   1110 H HB   . VAL A 1 112 ? -44.006 31.276 2.659   1.00 15.05 ? 78  VAL A HB   1 
ATOM   1111 H HG11 . VAL A 1 112 ? -42.105 30.382 1.470   1.00 19.03 ? 78  VAL A HG11 1 
ATOM   1112 H HG12 . VAL A 1 112 ? -42.663 29.484 2.655   1.00 19.03 ? 78  VAL A HG12 1 
ATOM   1113 H HG13 . VAL A 1 112 ? -43.023 29.126 1.150   1.00 19.03 ? 78  VAL A HG13 1 
ATOM   1114 H HG21 . VAL A 1 112 ? -43.366 32.174 0.589   1.00 21.40 ? 78  VAL A HG21 1 
ATOM   1115 H HG22 . VAL A 1 112 ? -44.290 31.114 -0.149  1.00 21.40 ? 78  VAL A HG22 1 
ATOM   1116 H HG23 . VAL A 1 112 ? -44.944 32.240 0.760   1.00 21.40 ? 78  VAL A HG23 1 
ATOM   1117 N N    . PHE A 1 113 ? -44.886 27.604 2.654   1.00 15.08 ? 79  PHE A N    1 
ATOM   1118 C CA   . PHE A 1 113 ? -44.793 26.446 3.534   1.00 13.39 ? 79  PHE A CA   1 
ATOM   1119 C C    . PHE A 1 113 ? -43.343 26.281 3.976   1.00 16.01 ? 79  PHE A C    1 
ATOM   1120 O O    . PHE A 1 113 ? -42.458 26.066 3.143   1.00 14.70 ? 79  PHE A O    1 
ATOM   1121 C CB   . PHE A 1 113 ? -45.307 25.206 2.798   1.00 19.67 ? 79  PHE A CB   1 
ATOM   1122 C CG   . PHE A 1 113 ? -44.969 23.896 3.457   1.00 11.84 ? 79  PHE A CG   1 
ATOM   1123 C CD1  . PHE A 1 113 ? -45.748 23.399 4.486   1.00 14.80 ? 79  PHE A CD1  1 
ATOM   1124 C CD2  . PHE A 1 113 ? -43.901 23.138 3.011   1.00 14.83 ? 79  PHE A CD2  1 
ATOM   1125 C CE1  . PHE A 1 113 ? -45.452 22.185 5.076   1.00 17.99 ? 79  PHE A CE1  1 
ATOM   1126 C CE2  . PHE A 1 113 ? -43.601 21.923 3.597   1.00 16.25 ? 79  PHE A CE2  1 
ATOM   1127 C CZ   . PHE A 1 113 ? -44.378 21.446 4.630   1.00 15.05 ? 79  PHE A CZ   1 
ATOM   1128 H H    . PHE A 1 113 ? -44.695 27.417 1.836   1.00 18.12 ? 79  PHE A H    1 
ATOM   1129 H HA   . PHE A 1 113 ? -45.327 26.573 4.334   1.00 16.10 ? 79  PHE A HA   1 
ATOM   1130 H HB2  . PHE A 1 113 ? -46.274 25.261 2.739   1.00 23.63 ? 79  PHE A HB2  1 
ATOM   1131 H HB3  . PHE A 1 113 ? -44.921 25.193 1.908   1.00 23.63 ? 79  PHE A HB3  1 
ATOM   1132 H HD1  . PHE A 1 113 ? -46.481 23.888 4.784   1.00 17.79 ? 79  PHE A HD1  1 
ATOM   1133 H HD2  . PHE A 1 113 ? -43.378 23.451 2.308   1.00 17.82 ? 79  PHE A HD2  1 
ATOM   1134 H HE1  . PHE A 1 113 ? -45.977 21.866 5.775   1.00 21.62 ? 79  PHE A HE1  1 
ATOM   1135 H HE2  . PHE A 1 113 ? -42.875 21.427 3.294   1.00 19.53 ? 79  PHE A HE2  1 
ATOM   1136 H HZ   . PHE A 1 113 ? -44.178 20.628 5.025   1.00 18.09 ? 79  PHE A HZ   1 
ATOM   1137 N N    . TYR A 1 114 ? -43.101 26.407 5.281   1.00 15.59 ? 80  TYR A N    1 
ATOM   1138 C CA   . TYR A 1 114 ? -41.754 26.250 5.819   1.00 16.38 ? 80  TYR A CA   1 
ATOM   1139 C C    . TYR A 1 114 ? -41.346 24.781 5.790   1.00 13.92 ? 80  TYR A C    1 
ATOM   1140 O O    . TYR A 1 114 ? -42.107 23.905 6.214   1.00 12.46 ? 80  TYR A O    1 
ATOM   1141 C CB   . TYR A 1 114 ? -41.690 26.794 7.249   1.00 19.74 ? 80  TYR A CB   1 
ATOM   1142 C CG   . TYR A 1 114 ? -40.329 26.690 7.915   1.00 12.01 ? 80  TYR A CG   1 
ATOM   1143 C CD1  . TYR A 1 114 ? -39.889 25.493 8.468   1.00 16.20 ? 80  TYR A CD1  1 
ATOM   1144 C CD2  . TYR A 1 114 ? -39.493 27.795 8.004   1.00 16.84 ? 80  TYR A CD2  1 
ATOM   1145 C CE1  . TYR A 1 114 ? -38.653 25.397 9.081   1.00 14.96 ? 80  TYR A CE1  1 
ATOM   1146 C CE2  . TYR A 1 114 ? -38.255 27.710 8.615   1.00 18.85 ? 80  TYR A CE2  1 
ATOM   1147 C CZ   . TYR A 1 114 ? -37.839 26.510 9.152   1.00 16.44 ? 80  TYR A CZ   1 
ATOM   1148 O OH   . TYR A 1 114 ? -36.608 26.423 9.761   1.00 16.42 ? 80  TYR A OH   1 
ATOM   1149 H H    . TYR A 1 114 ? -43.699 26.583 5.873   1.00 18.74 ? 80  TYR A H    1 
ATOM   1150 H HA   . TYR A 1 114 ? -41.127 26.752 5.276   1.00 19.69 ? 80  TYR A HA   1 
ATOM   1151 H HB2  . TYR A 1 114 ? -41.934 27.733 7.231   1.00 23.71 ? 80  TYR A HB2  1 
ATOM   1152 H HB3  . TYR A 1 114 ? -42.320 26.298 7.795   1.00 23.71 ? 80  TYR A HB3  1 
ATOM   1153 H HD1  . TYR A 1 114 ? -40.436 24.742 8.426   1.00 19.46 ? 80  TYR A HD1  1 
ATOM   1154 H HD2  . TYR A 1 114 ? -39.771 28.608 7.646   1.00 20.24 ? 80  TYR A HD2  1 
ATOM   1155 H HE1  . TYR A 1 114 ? -38.371 24.588 9.443   1.00 17.97 ? 80  TYR A HE1  1 
ATOM   1156 H HE2  . TYR A 1 114 ? -37.705 28.459 8.663   1.00 22.64 ? 80  TYR A HE2  1 
ATOM   1157 H HH   . TYR A 1 114 ? -36.196 27.150 9.680   1.00 19.73 ? 80  TYR A HH   1 
ATOM   1158 N N    . TRP A 1 115 ? -40.138 24.514 5.290   1.00 14.03 ? 81  TRP A N    1 
ATOM   1159 C CA   . TRP A 1 115 ? -39.634 23.144 5.191   1.00 12.52 ? 81  TRP A CA   1 
ATOM   1160 C C    . TRP A 1 115 ? -38.111 23.210 5.280   1.00 13.09 ? 81  TRP A C    1 
ATOM   1161 O O    . TRP A 1 115 ? -37.439 23.537 4.298   1.00 14.55 ? 81  TRP A O    1 
ATOM   1162 C CB   . TRP A 1 115 ? -40.107 22.487 3.901   1.00 14.27 ? 81  TRP A CB   1 
ATOM   1163 C CG   . TRP A 1 115 ? -39.904 20.991 3.813   1.00 16.88 ? 81  TRP A CG   1 
ATOM   1164 C CD1  . TRP A 1 115 ? -39.531 20.291 2.705   1.00 15.25 ? 81  TRP A CD1  1 
ATOM   1165 C CD2  . TRP A 1 115 ? -40.075 20.018 4.859   1.00 15.53 ? 81  TRP A CD2  1 
ATOM   1166 N NE1  . TRP A 1 115 ? -39.443 18.952 2.992   1.00 15.37 ? 81  TRP A NE1  1 
ATOM   1167 C CE2  . TRP A 1 115 ? -39.776 18.756 4.306   1.00 15.60 ? 81  TRP A CE2  1 
ATOM   1168 C CE3  . TRP A 1 115 ? -40.449 20.090 6.205   1.00 15.19 ? 81  TRP A CE3  1 
ATOM   1169 C CZ2  . TRP A 1 115 ? -39.836 17.580 5.051   1.00 13.81 ? 81  TRP A CZ2  1 
ATOM   1170 C CZ3  . TRP A 1 115 ? -40.507 18.922 6.942   1.00 15.48 ? 81  TRP A CZ3  1 
ATOM   1171 C CH2  . TRP A 1 115 ? -40.203 17.684 6.363   1.00 16.36 ? 81  TRP A CH2  1 
ATOM   1172 H H    . TRP A 1 115 ? -39.590 25.110 5.001   1.00 16.86 ? 81  TRP A H    1 
ATOM   1173 H HA   . TRP A 1 115 ? -39.957 22.617 5.939   1.00 15.05 ? 81  TRP A HA   1 
ATOM   1174 H HB2  . TRP A 1 115 ? -41.058 22.654 3.805   1.00 17.15 ? 81  TRP A HB2  1 
ATOM   1175 H HB3  . TRP A 1 115 ? -39.624 22.887 3.161   1.00 17.15 ? 81  TRP A HB3  1 
ATOM   1176 H HD1  . TRP A 1 115 ? -39.359 20.667 1.872   1.00 18.32 ? 81  TRP A HD1  1 
ATOM   1177 H HE1  . TRP A 1 115 ? -39.216 18.336 2.437   1.00 18.48 ? 81  TRP A HE1  1 
ATOM   1178 H HE3  . TRP A 1 115 ? -40.654 20.908 6.597   1.00 18.26 ? 81  TRP A HE3  1 
ATOM   1179 H HZ2  . TRP A 1 115 ? -39.635 16.756 4.669   1.00 16.60 ? 81  TRP A HZ2  1 
ATOM   1180 H HZ3  . TRP A 1 115 ? -40.753 18.959 7.838   1.00 18.60 ? 81  TRP A HZ3  1 
ATOM   1181 H HH2  . TRP A 1 115 ? -40.252 16.914 6.883   1.00 19.65 ? 81  TRP A HH2  1 
ATOM   1182 N N    . ASN A 1 116 ? -37.581 22.904 6.462   1.00 13.14 ? 82  ASN A N    1 
ATOM   1183 C CA   . ASN A 1 116 ? -36.147 23.011 6.694   1.00 13.88 ? 82  ASN A CA   1 
ATOM   1184 C C    . ASN A 1 116 ? -35.376 22.043 5.804   1.00 13.15 ? 82  ASN A C    1 
ATOM   1185 O O    . ASN A 1 116 ? -35.673 20.845 5.762   1.00 15.70 ? 82  ASN A O    1 
ATOM   1186 C CB   . ASN A 1 116 ? -35.840 22.734 8.164   1.00 12.14 ? 82  ASN A CB   1 
ATOM   1187 C CG   . ASN A 1 116 ? -34.505 23.300 8.593   1.00 16.46 ? 82  ASN A CG   1 
ATOM   1188 O OD1  . ASN A 1 116 ? -33.452 22.788 8.216   1.00 15.31 ? 82  ASN A OD1  1 
ATOM   1189 N ND2  . ASN A 1 116 ? -34.541 24.365 9.385   1.00 15.18 ? 82  ASN A ND2  1 
ATOM   1190 H H    . ASN A 1 116 ? -38.031 22.632 7.143   1.00 15.79 ? 82  ASN A H    1 
ATOM   1191 H HA   . ASN A 1 116 ? -35.855 23.911 6.480   1.00 16.68 ? 82  ASN A HA   1 
ATOM   1192 H HB2  . ASN A 1 116 ? -36.529 23.139 8.714   1.00 14.59 ? 82  ASN A HB2  1 
ATOM   1193 H HB3  . ASN A 1 116 ? -35.821 21.775 8.309   1.00 14.59 ? 82  ASN A HB3  1 
ATOM   1194 H HD21 . ASN A 1 116 ? -33.808 24.724 9.657   1.00 18.25 ? 82  ASN A HD21 1 
ATOM   1195 H HD22 . ASN A 1 116 ? -35.297 24.696 9.627   1.00 18.25 ? 82  ASN A HD22 1 
ATOM   1196 N N    . ALA A 1 117 ? -34.372 22.567 5.102   1.00 16.10 ? 83  ALA A N    1 
ATOM   1197 C CA   . ALA A 1 117 ? -33.578 21.776 4.171   1.00 20.41 ? 83  ALA A CA   1 
ATOM   1198 C C    . ALA A 1 117 ? -32.492 20.956 4.852   1.00 14.25 ? 83  ALA A C    1 
ATOM   1199 O O    . ALA A 1 117 ? -31.778 20.217 4.166   1.00 16.68 ? 83  ALA A O    1 
ATOM   1200 C CB   . ALA A 1 117 ? -32.929 22.692 3.128   1.00 14.48 ? 83  ALA A CB   1 
ATOM   1201 H H    . ALA A 1 117 ? -34.130 23.390 5.150   1.00 19.35 ? 83  ALA A H    1 
ATOM   1202 H HA   . ALA A 1 117 ? -34.173 21.162 3.713   1.00 24.52 ? 83  ALA A HA   1 
ATOM   1203 H HB1  . ALA A 1 117 ? -32.468 22.146 2.472   1.00 17.41 ? 83  ALA A HB1  1 
ATOM   1204 H HB2  . ALA A 1 117 ? -33.620 23.216 2.695   1.00 17.41 ? 83  ALA A HB2  1 
ATOM   1205 H HB3  . ALA A 1 117 ? -32.298 23.279 3.572   1.00 17.41 ? 83  ALA A HB3  1 
ATOM   1206 N N    . PHE A 1 118 ? -32.355 21.052 6.174   1.00 13.96 ? 84  PHE A N    1 
ATOM   1207 C CA   . PHE A 1 118 ? -31.219 20.450 6.866   1.00 12.64 ? 84  PHE A CA   1 
ATOM   1208 C C    . PHE A 1 118 ? -31.569 19.793 8.192   1.00 17.23 ? 84  PHE A C    1 
ATOM   1209 O O    . PHE A 1 118 ? -30.818 18.914 8.628   1.00 14.07 ? 84  PHE A O    1 
ATOM   1210 C CB   . PHE A 1 118 ? -30.141 21.518 7.109   1.00 15.40 ? 84  PHE A CB   1 
ATOM   1211 C CG   . PHE A 1 118 ? -28.783 20.971 7.486   1.00 18.60 ? 84  PHE A CG   1 
ATOM   1212 C CD1  . PHE A 1 118 ? -28.317 19.771 6.974   1.00 14.91 ? 84  PHE A CD1  1 
ATOM   1213 C CD2  . PHE A 1 118 ? -27.961 21.687 8.342   1.00 18.72 ? 84  PHE A CD2  1 
ATOM   1214 C CE1  . PHE A 1 118 ? -27.066 19.291 7.320   1.00 20.49 ? 84  PHE A CE1  1 
ATOM   1215 C CE2  . PHE A 1 118 ? -26.711 21.212 8.691   1.00 20.88 ? 84  PHE A CE2  1 
ATOM   1216 C CZ   . PHE A 1 118 ? -26.262 20.013 8.180   1.00 21.57 ? 84  PHE A CZ   1 
ATOM   1217 H H    . PHE A 1 118 ? -32.906 21.462 6.691   1.00 16.78 ? 84  PHE A H    1 
ATOM   1218 H HA   . PHE A 1 118 ? -30.838 19.757 6.304   1.00 15.19 ? 84  PHE A HA   1 
ATOM   1219 H HB2  . PHE A 1 118 ? -30.032 22.036 6.296   1.00 18.50 ? 84  PHE A HB2  1 
ATOM   1220 H HB3  . PHE A 1 118 ? -30.435 22.094 7.832   1.00 18.50 ? 84  PHE A HB3  1 
ATOM   1221 H HD1  . PHE A 1 118 ? -28.851 19.282 6.390   1.00 17.91 ? 84  PHE A HD1  1 
ATOM   1222 H HD2  . PHE A 1 118 ? -28.256 22.498 8.687   1.00 22.49 ? 84  PHE A HD2  1 
ATOM   1223 H HE1  . PHE A 1 118 ? -26.766 18.481 6.974   1.00 24.62 ? 84  PHE A HE1  1 
ATOM   1224 H HE2  . PHE A 1 118 ? -26.172 21.702 9.271   1.00 25.08 ? 84  PHE A HE2  1 
ATOM   1225 H HZ   . PHE A 1 118 ? -25.421 19.692 8.413   1.00 25.92 ? 84  PHE A HZ   1 
ATOM   1226 N N    . LEU A 1 119 ? -32.672 20.154 8.844   1.00 19.40 ? 85  LEU A N    1 
ATOM   1227 C CA   . LEU A 1 119 ? -32.962 19.723 10.204  1.00 15.55 ? 85  LEU A CA   1 
ATOM   1228 C C    . LEU A 1 119 ? -34.307 19.013 10.267  1.00 19.28 ? 85  LEU A C    1 
ATOM   1229 O O    . LEU A 1 119 ? -35.292 19.468 9.673   1.00 13.73 ? 85  LEU A O    1 
ATOM   1230 C CB   . LEU A 1 119 ? -32.954 20.919 11.159  1.00 13.32 ? 85  LEU A CB   1 
ATOM   1231 C CG   . LEU A 1 119 ? -31.706 21.801 11.077  1.00 16.36 ? 85  LEU A CG   1 
ATOM   1232 C CD1  . LEU A 1 119 ? -31.846 23.019 11.977  1.00 20.32 ? 85  LEU A CD1  1 
ATOM   1233 C CD2  . LEU A 1 119 ? -30.454 21.006 11.434  1.00 18.45 ? 85  LEU A CD2  1 
ATOM   1234 H H    . LEU A 1 119 ? -33.280 20.662 8.509   1.00 23.31 ? 85  LEU A H    1 
ATOM   1235 H HA   . LEU A 1 119 ? -32.288 19.087 10.490  1.00 18.69 ? 85  LEU A HA   1 
ATOM   1236 H HB2  . LEU A 1 119 ? -33.720 21.479 10.956  1.00 16.01 ? 85  LEU A HB2  1 
ATOM   1237 H HB3  . LEU A 1 119 ? -33.017 20.587 12.068  1.00 16.01 ? 85  LEU A HB3  1 
ATOM   1238 H HG   . LEU A 1 119 ? -31.607 22.115 10.164  1.00 19.66 ? 85  LEU A HG   1 
ATOM   1239 H HD11 . LEU A 1 119 ? -31.016 23.521 11.961  1.00 24.41 ? 85  LEU A HD11 1 
ATOM   1240 H HD12 . LEU A 1 119 ? -32.573 23.572 11.650  1.00 24.41 ? 85  LEU A HD12 1 
ATOM   1241 H HD13 . LEU A 1 119 ? -32.036 22.724 12.881  1.00 24.41 ? 85  LEU A HD13 1 
ATOM   1242 H HD21 . LEU A 1 119 ? -29.683 21.591 11.380  1.00 22.17 ? 85  LEU A HD21 1 
ATOM   1243 H HD22 . LEU A 1 119 ? -30.546 20.662 12.336  1.00 22.17 ? 85  LEU A HD22 1 
ATOM   1244 H HD23 . LEU A 1 119 ? -30.357 20.272 10.808  1.00 22.17 ? 85  LEU A HD23 1 
ATOM   1245 N N    . ASP A 1 120 ? -34.340 17.905 11.007  1.00 16.32 ? 86  ASP A N    1 
ATOM   1246 C CA   . ASP A 1 120 ? -35.521 17.052 11.137  1.00 18.38 ? 86  ASP A CA   1 
ATOM   1247 C C    . ASP A 1 120 ? -36.212 17.377 12.459  1.00 22.93 ? 86  ASP A C    1 
ATOM   1248 O O    . ASP A 1 120 ? -35.792 16.915 13.523  1.00 21.23 ? 86  ASP A O    1 
ATOM   1249 C CB   . ASP A 1 120 ? -35.118 15.583 11.058  1.00 22.52 ? 86  ASP A CB   1 
ATOM   1250 C CG   . ASP A 1 120 ? -36.176 14.653 11.611  1.00 23.44 ? 86  ASP A CG   1 
ATOM   1251 O OD1  . ASP A 1 120 ? -37.342 14.747 11.175  1.00 21.27 ? 86  ASP A OD1  1 
ATOM   1252 O OD2  . ASP A 1 120 ? -35.836 13.818 12.476  1.00 23.48 ? 86  ASP A OD2  1 
ATOM   1253 H H    . ASP A 1 120 ? -33.667 17.617 11.459  1.00 19.62 ? 86  ASP A H    1 
ATOM   1254 H HA   . ASP A 1 120 ? -36.144 17.248 10.419  1.00 22.08 ? 86  ASP A HA   1 
ATOM   1255 H HB2  . ASP A 1 120 ? -34.967 15.346 10.130  1.00 27.05 ? 86  ASP A HB2  1 
ATOM   1256 H HB3  . ASP A 1 120 ? -34.305 15.450 11.570  1.00 27.05 ? 86  ASP A HB3  1 
ATOM   1257 N N    . TYR A 1 121 ? -37.281 18.167 12.386  1.00 17.48 ? 87  TYR A N    1 
ATOM   1258 C CA   . TYR A 1 121 ? -38.023 18.608 13.559  1.00 18.55 ? 87  TYR A CA   1 
ATOM   1259 C C    . TYR A 1 121 ? -39.248 17.729 13.774  1.00 19.96 ? 87  TYR A C    1 
ATOM   1260 O O    . TYR A 1 121 ? -39.925 17.344 12.816  1.00 22.51 ? 87  TYR A O    1 
ATOM   1261 C CB   . TYR A 1 121 ? -38.465 20.064 13.405  1.00 19.77 ? 87  TYR A CB   1 
ATOM   1262 C CG   . TYR A 1 121 ? -37.373 21.086 13.633  1.00 19.40 ? 87  TYR A CG   1 
ATOM   1263 C CD1  . TYR A 1 121 ? -36.947 21.401 14.915  1.00 18.33 ? 87  TYR A CD1  1 
ATOM   1264 C CD2  . TYR A 1 121 ? -36.778 21.745 12.565  1.00 19.51 ? 87  TYR A CD2  1 
ATOM   1265 C CE1  . TYR A 1 121 ? -35.954 22.336 15.129  1.00 25.52 ? 87  TYR A CE1  1 
ATOM   1266 C CE2  . TYR A 1 121 ? -35.785 22.683 12.769  1.00 23.40 ? 87  TYR A CE2  1 
ATOM   1267 C CZ   . TYR A 1 121 ? -35.377 22.974 14.054  1.00 23.60 ? 87  TYR A CZ   1 
ATOM   1268 O OH   . TYR A 1 121 ? -34.389 23.908 14.266  1.00 26.21 ? 87  TYR A OH   1 
ATOM   1269 H H    . TYR A 1 121 ? -37.602 18.468 11.647  1.00 21.00 ? 87  TYR A H    1 
ATOM   1270 H HA   . TYR A 1 121 ? -37.452 18.535 14.340  1.00 22.29 ? 87  TYR A HA   1 
ATOM   1271 H HB2  . TYR A 1 121 ? -38.800 20.191 12.503  1.00 23.76 ? 87  TYR A HB2  1 
ATOM   1272 H HB3  . TYR A 1 121 ? -39.169 20.242 14.048  1.00 23.76 ? 87  TYR A HB3  1 
ATOM   1273 H HD1  . TYR A 1 121 ? -37.338 20.975 15.643  1.00 22.02 ? 87  TYR A HD1  1 
ATOM   1274 H HD2  . TYR A 1 121 ? -37.053 21.551 11.698  1.00 23.44 ? 87  TYR A HD2  1 
ATOM   1275 H HE1  . TYR A 1 121 ? -35.676 22.533 15.994  1.00 30.65 ? 87  TYR A HE1  1 
ATOM   1276 H HE2  . TYR A 1 121 ? -35.394 23.116 12.044  1.00 28.11 ? 87  TYR A HE2  1 
ATOM   1277 H HH   . TYR A 1 121 ? -34.243 23.990 15.089  1.00 31.47 ? 87  TYR A HH   1 
ATOM   1278 N N    . ASN A 1 122 ? -39.537 17.421 15.041  1.00 19.50 ? 88  ASN A N    1 
ATOM   1279 C CA   . ASN A 1 122 ? -40.737 16.666 15.402  1.00 26.10 ? 88  ASN A CA   1 
ATOM   1280 C C    . ASN A 1 122 ? -41.944 17.604 15.488  1.00 23.54 ? 88  ASN A C    1 
ATOM   1281 O O    . ASN A 1 122 ? -42.571 17.785 16.532  1.00 30.73 ? 88  ASN A O    1 
ATOM   1282 C CB   . ASN A 1 122 ? -40.528 15.920 16.713  1.00 26.57 ? 88  ASN A CB   1 
ATOM   1283 C CG   . ASN A 1 122 ? -41.696 15.011 17.056  1.00 32.88 ? 88  ASN A CG   1 
ATOM   1284 O OD1  . ASN A 1 122 ? -42.487 14.643 16.186  1.00 31.56 ? 88  ASN A OD1  1 
ATOM   1285 N ND2  . ASN A 1 122 ? -41.812 14.648 18.328  1.00 36.76 ? 88  ASN A ND2  1 
ATOM   1286 H H    . ASN A 1 122 ? -39.049 17.641 15.714  1.00 23.43 ? 88  ASN A H    1 
ATOM   1287 H HA   . ASN A 1 122 ? -40.906 16.007 14.710  1.00 31.35 ? 88  ASN A HA   1 
ATOM   1288 H HB2  . ASN A 1 122 ? -39.731 15.372 16.643  1.00 31.92 ? 88  ASN A HB2  1 
ATOM   1289 H HB3  . ASN A 1 122 ? -40.426 16.563 17.432  1.00 31.92 ? 88  ASN A HB3  1 
ATOM   1290 H HD21 . ASN A 1 122 ? -42.457 14.134 18.571  1.00 44.14 ? 88  ASN A HD21 1 
ATOM   1291 H HD22 . ASN A 1 122 ? -41.242 14.926 18.908  1.00 44.14 ? 88  ASN A HD22 1 
ATOM   1292 N N    . LEU A 1 123 ? -42.254 18.215 14.345  1.00 19.88 ? 89  LEU A N    1 
ATOM   1293 C CA   . LEU A 1 123 ? -43.386 19.122 14.217  1.00 22.53 ? 89  LEU A CA   1 
ATOM   1294 C C    . LEU A 1 123 ? -44.195 18.831 12.960  1.00 19.33 ? 89  LEU A C    1 
ATOM   1295 O O    . LEU A 1 123 ? -45.130 19.579 12.648  1.00 18.39 ? 89  LEU A O    1 
ATOM   1296 C CB   . LEU A 1 123 ? -42.907 20.579 14.200  1.00 19.54 ? 89  LEU A CB   1 
ATOM   1297 C CG   . LEU A 1 123 ? -42.156 21.043 15.449  1.00 21.50 ? 89  LEU A CG   1 
ATOM   1298 C CD1  . LEU A 1 123 ? -41.537 22.414 15.226  1.00 22.89 ? 89  LEU A CD1  1 
ATOM   1299 C CD2  . LEU A 1 123 ? -43.081 21.061 16.655  1.00 24.01 ? 89  LEU A CD2  1 
ATOM   1300 H H    . LEU A 1 123 ? -41.812 18.116 13.614  1.00 23.88 ? 89  LEU A H    1 
ATOM   1301 H HA   . LEU A 1 123 ? -43.970 19.016 14.984  1.00 27.06 ? 89  LEU A HA   1 
ATOM   1302 H HB2  . LEU A 1 123 ? -42.310 20.693 13.444  1.00 23.48 ? 89  LEU A HB2  1 
ATOM   1303 H HB3  . LEU A 1 123 ? -43.683 21.153 14.100  1.00 23.48 ? 89  LEU A HB3  1 
ATOM   1304 H HG   . LEU A 1 123 ? -41.437 20.418 15.633  1.00 25.83 ? 89  LEU A HG   1 
ATOM   1305 H HD11 . LEU A 1 123 ? -41.068 22.684 16.031  1.00 27.50 ? 89  LEU A HD11 1 
ATOM   1306 H HD12 . LEU A 1 123 ? -40.916 22.363 14.483  1.00 27.50 ? 89  LEU A HD12 1 
ATOM   1307 H HD13 . LEU A 1 123 ? -42.242 23.049 15.025  1.00 27.50 ? 89  LEU A HD13 1 
ATOM   1308 H HD21 . LEU A 1 123 ? -42.618 21.470 17.402  1.00 28.83 ? 89  LEU A HD21 1 
ATOM   1309 H HD22 . LEU A 1 123 ? -43.875 21.574 16.436  1.00 28.83 ? 89  LEU A HD22 1 
ATOM   1310 H HD23 . LEU A 1 123 ? -43.328 20.149 16.877  1.00 28.83 ? 89  LEU A HD23 1 
ATOM   1311 N N    . TYR A 1 124 ? -43.857 17.767 12.238  1.00 17.62 ? 90  TYR A N    1 
ATOM   1312 C CA   . TYR A 1 124 ? -44.491 17.414 10.980  1.00 20.84 ? 90  TYR A CA   1 
ATOM   1313 C C    . TYR A 1 124 ? -44.919 15.956 11.027  1.00 21.04 ? 90  TYR A C    1 
ATOM   1314 O O    . TYR A 1 124 ? -44.285 15.131 11.692  1.00 17.77 ? 90  TYR A O    1 
ATOM   1315 C CB   . TYR A 1 124 ? -43.532 17.609 9.795   1.00 18.48 ? 90  TYR A CB   1 
ATOM   1316 C CG   . TYR A 1 124 ? -43.094 19.035 9.541   1.00 15.41 ? 90  TYR A CG   1 
ATOM   1317 C CD1  . TYR A 1 124 ? -42.229 19.684 10.411  1.00 16.17 ? 90  TYR A CD1  1 
ATOM   1318 C CD2  . TYR A 1 124 ? -43.520 19.718 8.411   1.00 14.22 ? 90  TYR A CD2  1 
ATOM   1319 C CE1  . TYR A 1 124 ? -41.819 20.983 10.173  1.00 14.07 ? 90  TYR A CE1  1 
ATOM   1320 C CE2  . TYR A 1 124 ? -43.115 21.014 8.164   1.00 14.06 ? 90  TYR A CE2  1 
ATOM   1321 C CZ   . TYR A 1 124 ? -42.264 21.643 9.045   1.00 13.34 ? 90  TYR A CZ   1 
ATOM   1322 O OH   . TYR A 1 124 ? -41.859 22.936 8.796   1.00 14.83 ? 90  TYR A OH   1 
ATOM   1323 H H    . TYR A 1 124 ? -43.239 17.215 12.468  1.00 21.18 ? 90  TYR A H    1 
ATOM   1324 H HA   . TYR A 1 124 ? -45.273 17.972 10.846  1.00 25.04 ? 90  TYR A HA   1 
ATOM   1325 H HB2  . TYR A 1 124 ? -42.732 17.086 9.960   1.00 22.20 ? 90  TYR A HB2  1 
ATOM   1326 H HB3  . TYR A 1 124 ? -43.974 17.295 8.991   1.00 22.20 ? 90  TYR A HB3  1 
ATOM   1327 H HD1  . TYR A 1 124 ? -41.920 19.238 11.166  1.00 19.43 ? 90  TYR A HD1  1 
ATOM   1328 H HD2  . TYR A 1 124 ? -44.088 19.294 7.809   1.00 17.09 ? 90  TYR A HD2  1 
ATOM   1329 H HE1  . TYR A 1 124 ? -41.247 21.410 10.769  1.00 16.91 ? 90  TYR A HE1  1 
ATOM   1330 H HE2  . TYR A 1 124 ? -43.415 21.460 7.406   1.00 16.90 ? 90  TYR A HE2  1 
ATOM   1331 H HH   . TYR A 1 124 ? -42.121 23.178 8.036   1.00 17.82 ? 90  TYR A HH   1 
ATOM   1332 N N    . ASP A 1 125 ? -46.000 15.639 10.312  1.00 23.69 ? 91  ASP A N    1 
ATOM   1333 C CA   . ASP A 1 125 ? -46.278 14.238 10.023  1.00 19.05 ? 91  ASP A CA   1 
ATOM   1334 C C    . ASP A 1 125 ? -45.092 13.593 9.321   1.00 21.80 ? 91  ASP A C    1 
ATOM   1335 O O    . ASP A 1 125 ? -44.830 12.400 9.506   1.00 19.90 ? 91  ASP A O    1 
ATOM   1336 C CB   . ASP A 1 125 ? -47.532 14.107 9.158   1.00 21.30 ? 91  ASP A CB   1 
ATOM   1337 C CG   . ASP A 1 125 ? -48.775 14.632 9.845   1.00 21.31 ? 91  ASP A CG   1 
ATOM   1338 O OD1  . ASP A 1 125 ? -48.953 14.353 11.049  1.00 25.85 ? 91  ASP A OD1  1 
ATOM   1339 O OD2  . ASP A 1 125 ? -49.573 15.323 9.178   1.00 26.15 ? 91  ASP A OD2  1 
ATOM   1340 H H    . ASP A 1 125 ? -46.569 16.200 9.995   1.00 28.46 ? 91  ASP A H    1 
ATOM   1341 H HA   . ASP A 1 125 ? -46.447 13.770 10.855  1.00 22.89 ? 91  ASP A HA   1 
ATOM   1342 H HB2  . ASP A 1 125 ? -47.405 14.613 8.340   1.00 25.59 ? 91  ASP A HB2  1 
ATOM   1343 H HB3  . ASP A 1 125 ? -47.676 13.171 8.950   1.00 25.59 ? 91  ASP A HB3  1 
ATOM   1344 N N    . ALA A 1 126 ? -44.357 14.376 8.526   1.00 18.82 ? 92  ALA A N    1 
ATOM   1345 C CA   . ALA A 1 126 ? -43.209 13.847 7.800   1.00 20.91 ? 92  ALA A CA   1 
ATOM   1346 C C    . ALA A 1 126 ? -42.145 13.303 8.742   1.00 22.13 ? 92  ALA A C    1 
ATOM   1347 O O    . ALA A 1 126 ? -41.390 12.399 8.367   1.00 22.19 ? 92  ALA A O    1 
ATOM   1348 C CB   . ALA A 1 126 ? -42.614 14.937 6.908   1.00 17.84 ? 92  ALA A CB   1 
ATOM   1349 H H    . ALA A 1 126 ? -44.504 15.213 8.392   1.00 22.62 ? 92  ALA A H    1 
ATOM   1350 H HA   . ALA A 1 126 ? -43.507 13.117 7.236   1.00 25.12 ? 92  ALA A HA   1 
ATOM   1351 H HB1  . ALA A 1 126 ? -41.842 14.577 6.443   1.00 21.43 ? 92  ALA A HB1  1 
ATOM   1352 H HB2  . ALA A 1 126 ? -43.284 15.221 6.267   1.00 21.43 ? 92  ALA A HB2  1 
ATOM   1353 H HB3  . ALA A 1 126 ? -42.347 15.687 7.461   1.00 21.43 ? 92  ALA A HB3  1 
ATOM   1354 N N    . HIS A 1 127 ? -42.060 13.841 9.962   1.00 17.63 ? 93  HIS A N    1 
ATOM   1355 C CA   . HIS A 1 127 ? -41.051 13.362 10.900  1.00 23.19 ? 93  HIS A CA   1 
ATOM   1356 C C    . HIS A 1 127 ? -41.191 11.865 11.137  1.00 22.30 ? 93  HIS A C    1 
ATOM   1357 O O    . HIS A 1 127 ? -40.193 11.135 11.149  1.00 23.34 ? 93  HIS A O    1 
ATOM   1358 C CB   . HIS A 1 127 ? -41.151 14.118 12.223  1.00 22.02 ? 93  HIS A CB   1 
ATOM   1359 C CG   . HIS A 1 127 ? -40.250 13.580 13.290  1.00 24.99 ? 93  HIS A CG   1 
ATOM   1360 N ND1  . HIS A 1 127 ? -38.877 13.680 13.222  1.00 24.82 ? 93  HIS A ND1  1 
ATOM   1361 C CD2  . HIS A 1 127 ? -40.522 12.929 14.445  1.00 27.81 ? 93  HIS A CD2  1 
ATOM   1362 C CE1  . HIS A 1 127 ? -38.343 13.119 14.292  1.00 28.19 ? 93  HIS A CE1  1 
ATOM   1363 N NE2  . HIS A 1 127 ? -39.320 12.656 15.051  1.00 26.91 ? 93  HIS A NE2  1 
ATOM   1364 H H    . HIS A 1 127 ? -42.564 14.469 10.262  1.00 21.19 ? 93  HIS A H    1 
ATOM   1365 H HA   . HIS A 1 127 ? -40.173 13.534 10.523  1.00 27.86 ? 93  HIS A HA   1 
ATOM   1366 H HB2  . HIS A 1 127 ? -40.912 15.046 12.072  1.00 26.45 ? 93  HIS A HB2  1 
ATOM   1367 H HB3  . HIS A 1 127 ? -42.063 14.059 12.547  1.00 26.45 ? 93  HIS A HB3  1 
ATOM   1368 H HD1  . HIS A 1 127 ? -38.436 14.050 12.582  1.00 29.81 ? 93  HIS A HD1  1 
ATOM   1369 H HD2  . HIS A 1 127 ? -41.366 12.707 14.769  1.00 33.40 ? 93  HIS A HD2  1 
ATOM   1370 H HE1  . HIS A 1 127 ? -37.434 13.061 14.480  1.00 33.85 ? 93  HIS A HE1  1 
ATOM   1371 N N    . LYS A 1 128 ? -42.424 11.389 11.324  1.00 25.99 ? 94  LYS A N    1 
ATOM   1372 C CA   . LYS A 1 128 ? -42.633 9.962  11.534  1.00 25.18 ? 94  LYS A CA   1 
ATOM   1373 C C    . LYS A 1 128 ? -42.088 9.158  10.366  1.00 27.21 ? 94  LYS A C    1 
ATOM   1374 O O    . LYS A 1 128 ? -41.490 8.092  10.558  1.00 25.71 ? 94  LYS A O    1 
ATOM   1375 C CB   . LYS A 1 128 ? -44.119 9.671  11.738  1.00 18.95 ? 94  LYS A CB   1 
ATOM   1376 H H    . LYS A 1 128 ? -43.141 11.864 11.332  1.00 31.22 ? 94  LYS A H    1 
ATOM   1377 H HA   . LYS A 1 128 ? -42.164 9.689  12.339  1.00 30.25 ? 94  LYS A HA   1 
ATOM   1378 N N    . GLU A 1 129 ? -42.267 9.656  9.144   1.00 23.47 ? 95  GLU A N    1 
ATOM   1379 C CA   . GLU A 1 129 ? -41.707 8.952  8.001   1.00 28.07 ? 95  GLU A CA   1 
ATOM   1380 C C    . GLU A 1 129 ? -40.182 8.957  8.069   1.00 28.93 ? 95  GLU A C    1 
ATOM   1381 O O    . GLU A 1 129 ? -39.550 7.903  7.944   1.00 27.34 ? 95  GLU A O    1 
ATOM   1382 C CB   . GLU A 1 129 ? -42.233 9.569  6.701   1.00 28.12 ? 95  GLU A CB   1 
ATOM   1383 C CG   . GLU A 1 129 ? -42.124 8.667  5.474   1.00 34.76 ? 95  GLU A CG   1 
ATOM   1384 C CD   . GLU A 1 129 ? -43.022 9.124  4.331   1.00 41.13 ? 95  GLU A CD   1 
ATOM   1385 O OE1  . GLU A 1 129 ? -43.295 10.341 4.231   1.00 35.73 ? 95  GLU A OE1  1 
ATOM   1386 O OE2  . GLU A 1 129 ? -43.459 8.265  3.536   1.00 48.53 ? 95  GLU A OE2  1 
ATOM   1387 H H    . GLU A 1 129 ? -42.695 10.378 8.958   1.00 28.19 ? 95  GLU A H    1 
ATOM   1388 H HA   . GLU A 1 129 ? -41.994 8.026  8.007   1.00 33.72 ? 95  GLU A HA   1 
ATOM   1389 H HB2  . GLU A 1 129 ? -43.171 9.786  6.821   1.00 33.77 ? 95  GLU A HB2  1 
ATOM   1390 H HB3  . GLU A 1 129 ? -41.727 10.376 6.516   1.00 33.77 ? 95  GLU A HB3  1 
ATOM   1391 H HG2  . GLU A 1 129 ? -41.207 8.673  5.157   1.00 41.74 ? 95  GLU A HG2  1 
ATOM   1392 H HG3  . GLU A 1 129 ? -42.384 7.765  5.719   1.00 41.74 ? 95  GLU A HG3  1 
ATOM   1393 N N    . TYR A 1 130 ? -39.575 10.117 8.345   1.00 26.25 ? 96  TYR A N    1 
ATOM   1394 C CA   . TYR A 1 130 ? -38.116 10.181 8.392   1.00 23.41 ? 96  TYR A CA   1 
ATOM   1395 C C    . TYR A 1 130 ? -37.555 9.232  9.447   1.00 27.73 ? 96  TYR A C    1 
ATOM   1396 O O    . TYR A 1 130 ? -36.562 8.537  9.200   1.00 26.79 ? 96  TYR A O    1 
ATOM   1397 C CB   . TYR A 1 130 ? -37.646 11.611 8.662   1.00 22.24 ? 96  TYR A CB   1 
ATOM   1398 C CG   . TYR A 1 130 ? -36.149 11.772 8.523   1.00 20.82 ? 96  TYR A CG   1 
ATOM   1399 C CD1  . TYR A 1 130 ? -35.545 11.759 7.274   1.00 19.55 ? 96  TYR A CD1  1 
ATOM   1400 C CD2  . TYR A 1 130 ? -35.338 11.920 9.641   1.00 22.34 ? 96  TYR A CD2  1 
ATOM   1401 C CE1  . TYR A 1 130 ? -34.177 11.896 7.139   1.00 17.54 ? 96  TYR A CE1  1 
ATOM   1402 C CE2  . TYR A 1 130 ? -33.968 12.058 9.515   1.00 19.44 ? 96  TYR A CE2  1 
ATOM   1403 C CZ   . TYR A 1 130 ? -33.394 12.045 8.261   1.00 19.16 ? 96  TYR A CZ   1 
ATOM   1404 O OH   . TYR A 1 130 ? -32.032 12.180 8.123   1.00 22.68 ? 96  TYR A OH   1 
ATOM   1405 H H    . TYR A 1 130 ? -39.976 10.861 8.504   1.00 31.52 ? 96  TYR A H    1 
ATOM   1406 H HA   . TYR A 1 130 ? -37.772 9.913  7.525   1.00 28.12 ? 96  TYR A HA   1 
ATOM   1407 H HB2  . TYR A 1 130 ? -38.072 12.209 8.027   1.00 26.71 ? 96  TYR A HB2  1 
ATOM   1408 H HB3  . TYR A 1 130 ? -37.892 11.859 9.567   1.00 26.71 ? 96  TYR A HB3  1 
ATOM   1409 H HD1  . TYR A 1 130 ? -36.071 11.656 6.514   1.00 23.48 ? 96  TYR A HD1  1 
ATOM   1410 H HD2  . TYR A 1 130 ? -35.723 11.926 10.487  1.00 26.84 ? 96  TYR A HD2  1 
ATOM   1411 H HE1  . TYR A 1 130 ? -33.788 11.889 6.295   1.00 21.08 ? 96  TYR A HE1  1 
ATOM   1412 H HE2  . TYR A 1 130 ? -33.436 12.160 10.271  1.00 23.35 ? 96  TYR A HE2  1 
ATOM   1413 H HH   . TYR A 1 130 ? -31.657 12.087 8.869   1.00 27.24 ? 96  TYR A HH   1 
ATOM   1414 N N    . GLU A 1 131 ? -38.178 9.190  10.629  1.00 27.63 ? 97  GLU A N    1 
ATOM   1415 C CA   . GLU A 1 131 ? -37.736 8.269  11.672  1.00 30.94 ? 97  GLU A CA   1 
ATOM   1416 C C    . GLU A 1 131 ? -37.735 6.825  11.185  1.00 29.48 ? 97  GLU A C    1 
ATOM   1417 O O    . GLU A 1 131 ? -36.957 6.003  11.682  1.00 28.15 ? 97  GLU A O    1 
ATOM   1418 C CB   . GLU A 1 131 ? -38.638 8.404  12.899  1.00 29.23 ? 97  GLU A CB   1 
ATOM   1419 C CG   . GLU A 1 131 ? -38.318 9.595  13.782  1.00 40.23 ? 97  GLU A CG   1 
ATOM   1420 C CD   . GLU A 1 131 ? -37.016 9.430  14.537  1.00 43.30 ? 97  GLU A CD   1 
ATOM   1421 O OE1  . GLU A 1 131 ? -36.770 8.324  15.064  1.00 46.38 ? 97  GLU A OE1  1 
ATOM   1422 O OE2  . GLU A 1 131 ? -36.239 10.406 14.603  1.00 37.11 ? 97  GLU A OE2  1 
ATOM   1423 H H    . GLU A 1 131 ? -38.851 9.679  10.847  1.00 33.19 ? 97  GLU A H    1 
ATOM   1424 H HA   . GLU A 1 131 ? -36.830 8.501  11.928  1.00 37.15 ? 97  GLU A HA   1 
ATOM   1425 H HB2  . GLU A 1 131 ? -39.556 8.498  12.600  1.00 35.10 ? 97  GLU A HB2  1 
ATOM   1426 H HB3  . GLU A 1 131 ? -38.545 7.604  13.441  1.00 35.10 ? 97  GLU A HB3  1 
ATOM   1427 H HG2  . GLU A 1 131 ? -38.246 10.389 13.228  1.00 48.30 ? 97  GLU A HG2  1 
ATOM   1428 H HG3  . GLU A 1 131 ? -39.030 9.708  14.431  1.00 48.30 ? 97  GLU A HG3  1 
ATOM   1429 N N    . ASN A 1 132 ? -38.593 6.499  10.221  1.00 30.30 ? 98  ASN A N    1 
ATOM   1430 C CA   . ASN A 1 132 ? -38.737 5.143  9.713   1.00 28.13 ? 98  ASN A CA   1 
ATOM   1431 C C    . ASN A 1 132 ? -37.749 4.813  8.599   1.00 30.26 ? 98  ASN A C    1 
ATOM   1432 O O    . ASN A 1 132 ? -37.885 3.764  7.960   1.00 30.62 ? 98  ASN A O    1 
ATOM   1433 C CB   . ASN A 1 132 ? -40.165 4.931  9.201   1.00 30.19 ? 98  ASN A CB   1 
ATOM   1434 C CG   . ASN A 1 132 ? -41.094 4.388  10.268  1.00 41.38 ? 98  ASN A CG   1 
ATOM   1435 O OD1  . ASN A 1 132 ? -40.687 3.606  11.127  1.00 47.93 ? 98  ASN A OD1  1 
ATOM   1436 N ND2  . ASN A 1 132 ? -42.356 4.802  10.215  1.00 45.92 ? 98  ASN A ND2  1 
ATOM   1437 H H    . ASN A 1 132 ? -39.115 7.064  9.836   1.00 36.39 ? 98  ASN A H    1 
ATOM   1438 H HA   . ASN A 1 132 ? -38.575 4.526  10.444  1.00 33.79 ? 98  ASN A HA   1 
ATOM   1439 H HB2  . ASN A 1 132 ? -40.521 5.780  8.897   1.00 36.25 ? 98  ASN A HB2  1 
ATOM   1440 H HB3  . ASN A 1 132 ? -40.147 4.296  8.468   1.00 36.25 ? 98  ASN A HB3  1 
ATOM   1441 H HD21 . ASN A 1 132 ? -42.604 5.347  9.599   1.00 55.13 ? 98  ASN A HD21 1 
ATOM   1442 H HD22 . ASN A 1 132 ? -42.924 4.523  10.798  1.00 55.13 ? 98  ASN A HD22 1 
ATOM   1443 N N    . HIS A 1 133 ? -36.759 5.672  8.353   1.00 29.84 ? 99  HIS A N    1 
ATOM   1444 C CA   . HIS A 1 133 ? -35.841 5.499  7.233   1.00 31.85 ? 99  HIS A CA   1 
ATOM   1445 C C    . HIS A 1 133 ? -34.405 5.772  7.688   1.00 27.41 ? 99  HIS A C    1 
ATOM   1446 O O    . HIS A 1 133 ? -33.735 6.689  7.222   1.00 24.36 ? 99  HIS A O    1 
ATOM   1447 C CB   . HIS A 1 133 ? -36.242 6.402  6.066   1.00 28.79 ? 99  HIS A CB   1 
ATOM   1448 C CG   . HIS A 1 133 ? -37.503 5.976  5.381   1.00 31.91 ? 99  HIS A CG   1 
ATOM   1449 N ND1  . HIS A 1 133 ? -37.530 4.990  4.420   1.00 38.71 ? 99  HIS A ND1  1 
ATOM   1450 C CD2  . HIS A 1 133 ? -38.780 6.404  5.516   1.00 34.81 ? 99  HIS A CD2  1 
ATOM   1451 C CE1  . HIS A 1 133 ? -38.770 4.826  3.994   1.00 40.56 ? 99  HIS A CE1  1 
ATOM   1452 N NE2  . HIS A 1 133 ? -39.548 5.672  4.644   1.00 41.45 ? 99  HIS A NE2  1 
ATOM   1453 H H    . HIS A 1 133 ? -36.599 6.371  8.829   1.00 35.83 ? 99  HIS A H    1 
ATOM   1454 H HA   . HIS A 1 133 ? -35.882 4.576  6.938   1.00 38.25 ? 99  HIS A HA   1 
ATOM   1455 H HB2  . HIS A 1 133 ? -36.376 7.303  6.401   1.00 34.58 ? 99  HIS A HB2  1 
ATOM   1456 H HB3  . HIS A 1 133 ? -35.530 6.396  5.408   1.00 34.58 ? 99  HIS A HB3  1 
ATOM   1457 H HD1  . HIS A 1 133 ? -36.847 4.550  4.140   1.00 46.48 ? 99  HIS A HD1  1 
ATOM   1458 H HD2  . HIS A 1 133 ? -39.081 7.068  6.093   1.00 41.80 ? 99  HIS A HD2  1 
ATOM   1459 H HE1  . HIS A 1 133 ? -39.047 4.219  3.347   1.00 48.70 ? 99  HIS A HE1  1 
ATOM   1460 N N    . LYS A 1 134 ? -33.925 4.946  8.624   1.00 28.64 ? 100 LYS A N    1 
ATOM   1461 C CA   . LYS A 1 134 ? -32.536 5.042  9.065   1.00 32.65 ? 100 LYS A CA   1 
ATOM   1462 C C    . LYS A 1 134 ? -31.573 5.057  7.886   1.00 30.94 ? 100 LYS A C    1 
ATOM   1463 O O    . LYS A 1 134 ? -30.525 5.711  7.938   1.00 32.43 ? 100 LYS A O    1 
ATOM   1464 C CB   . LYS A 1 134 ? -32.185 3.867  9.983   1.00 39.64 ? 100 LYS A CB   1 
ATOM   1465 C CG   . LYS A 1 134 ? -32.917 3.839  11.321  1.00 46.45 ? 100 LYS A CG   1 
ATOM   1466 C CD   . LYS A 1 134 ? -31.991 3.619  12.535  1.00 48.36 ? 100 LYS A CD   1 
ATOM   1467 C CE   . LYS A 1 134 ? -30.833 2.645  12.276  1.00 59.94 ? 100 LYS A CE   1 
ATOM   1468 N NZ   . LYS A 1 134 ? -30.008 2.413  13.496  1.00 52.67 ? 100 LYS A NZ   1 
ATOM   1469 H H    . LYS A 1 134 ? -34.379 4.329  9.013   1.00 34.39 ? 100 LYS A H    1 
ATOM   1470 H HA   . LYS A 1 134 ? -32.433 5.865  9.567   1.00 39.21 ? 100 LYS A HA   1 
ATOM   1471 H HB2  . LYS A 1 134 ? -32.400 3.043  9.519   1.00 47.59 ? 100 LYS A HB2  1 
ATOM   1472 H HB3  . LYS A 1 134 ? -31.235 3.902  10.174  1.00 47.59 ? 100 LYS A HB3  1 
ATOM   1473 H HG2  . LYS A 1 134 ? -33.371 4.687  11.446  1.00 55.77 ? 100 LYS A HG2  1 
ATOM   1474 H HG3  . LYS A 1 134 ? -33.564 3.116  11.308  1.00 55.77 ? 100 LYS A HG3  1 
ATOM   1475 H HD2  . LYS A 1 134 ? -31.606 4.472  12.791  1.00 58.06 ? 100 LYS A HD2  1 
ATOM   1476 H HD3  . LYS A 1 134 ? -32.518 3.261  13.267  1.00 58.06 ? 100 LYS A HD3  1 
ATOM   1477 H HE2  . LYS A 1 134 ? -31.193 1.792  11.988  1.00 71.96 ? 100 LYS A HE2  1 
ATOM   1478 H HE3  . LYS A 1 134 ? -30.257 3.012  11.587  1.00 71.96 ? 100 LYS A HE3  1 
ATOM   1479 H HZ1  . LYS A 1 134 ? -29.319 1.885  13.302  1.00 63.23 ? 100 LYS A HZ1  1 
ATOM   1480 H HZ2  . LYS A 1 134 ? -29.699 3.188  13.807  1.00 63.23 ? 100 LYS A HZ2  1 
ATOM   1481 H HZ3  . LYS A 1 134 ? -30.500 2.025  14.127  1.00 63.23 ? 100 LYS A HZ3  1 
ATOM   1482 N N    . GLU A 1 135 ? -31.909 4.335  6.815   1.00 27.12 ? 101 GLU A N    1 
ATOM   1483 C CA   . GLU A 1 135 ? -31.000 4.204  5.683   1.00 31.14 ? 101 GLU A CA   1 
ATOM   1484 C C    . GLU A 1 135 ? -30.576 5.553  5.113   1.00 32.86 ? 101 GLU A C    1 
ATOM   1485 O O    . GLU A 1 135 ? -29.571 5.619  4.396   1.00 33.34 ? 101 GLU A O    1 
ATOM   1486 C CB   . GLU A 1 135 ? -31.657 3.347  4.597   1.00 28.29 ? 101 GLU A CB   1 
ATOM   1487 C CG   . GLU A 1 135 ? -32.897 3.968  3.960   1.00 25.60 ? 101 GLU A CG   1 
ATOM   1488 C CD   . GLU A 1 135 ? -34.189 3.481  4.586   1.00 27.24 ? 101 GLU A CD   1 
ATOM   1489 O OE1  . GLU A 1 135 ? -34.196 3.197  5.803   1.00 27.50 ? 101 GLU A OE1  1 
ATOM   1490 O OE2  . GLU A 1 135 ? -35.202 3.389  3.861   1.00 32.12 ? 101 GLU A OE2  1 
ATOM   1491 H H    . GLU A 1 135 ? -32.653 3.915  6.722   1.00 32.57 ? 101 GLU A H    1 
ATOM   1492 H HA   . GLU A 1 135 ? -30.193 3.753  5.978   1.00 37.40 ? 101 GLU A HA   1 
ATOM   1493 H HB2  . GLU A 1 135 ? -31.010 3.196  3.890   1.00 33.97 ? 101 GLU A HB2  1 
ATOM   1494 H HB3  . GLU A 1 135 ? -31.923 2.501  4.990   1.00 33.97 ? 101 GLU A HB3  1 
ATOM   1495 H HG2  . GLU A 1 135 ? -32.857 4.932  4.067   1.00 30.75 ? 101 GLU A HG2  1 
ATOM   1496 H HG3  . GLU A 1 135 ? -32.916 3.739  3.018   1.00 30.75 ? 101 GLU A HG3  1 
ATOM   1497 N N    . TRP A 1 136 ? -31.311 6.626  5.413   1.00 31.78 ? 102 TRP A N    1 
ATOM   1498 C CA   . TRP A 1 136 ? -30.960 7.957  4.938   1.00 29.77 ? 102 TRP A CA   1 
ATOM   1499 C C    . TRP A 1 136 ? -30.146 8.763  5.940   1.00 27.69 ? 102 TRP A C    1 
ATOM   1500 O O    . TRP A 1 136 ? -29.480 9.725  5.540   1.00 27.92 ? 102 TRP A O    1 
ATOM   1501 C CB   . TRP A 1 136 ? -32.220 8.768  4.620   1.00 22.87 ? 102 TRP A CB   1 
ATOM   1502 C CG   . TRP A 1 136 ? -33.144 8.163  3.618   1.00 24.45 ? 102 TRP A CG   1 
ATOM   1503 C CD1  . TRP A 1 136 ? -32.831 7.272  2.634   1.00 29.13 ? 102 TRP A CD1  1 
ATOM   1504 C CD2  . TRP A 1 136 ? -34.546 8.420  3.497   1.00 21.84 ? 102 TRP A CD2  1 
ATOM   1505 N NE1  . TRP A 1 136 ? -33.958 6.955  1.909   1.00 27.93 ? 102 TRP A NE1  1 
ATOM   1506 C CE2  . TRP A 1 136 ? -35.023 7.649  2.420   1.00 22.66 ? 102 TRP A CE2  1 
ATOM   1507 C CE3  . TRP A 1 136 ? -35.446 9.230  4.199   1.00 24.72 ? 102 TRP A CE3  1 
ATOM   1508 C CZ2  . TRP A 1 136 ? -36.360 7.661  2.029   1.00 26.11 ? 102 TRP A CZ2  1 
ATOM   1509 C CZ3  . TRP A 1 136 ? -36.771 9.240  3.810   1.00 23.59 ? 102 TRP A CZ3  1 
ATOM   1510 C CH2  . TRP A 1 136 ? -37.216 8.461  2.735   1.00 26.59 ? 102 TRP A CH2  1 
ATOM   1511 H H    . TRP A 1 136 ? -32.023 6.604  5.895   1.00 38.16 ? 102 TRP A H    1 
ATOM   1512 H HA   . TRP A 1 136 ? -30.444 7.852  4.124   1.00 35.75 ? 102 TRP A HA   1 
ATOM   1513 H HB2  . TRP A 1 136 ? -32.723 8.883  5.442   1.00 27.48 ? 102 TRP A HB2  1 
ATOM   1514 H HB3  . TRP A 1 136 ? -31.947 9.632  4.275   1.00 27.48 ? 102 TRP A HB3  1 
ATOM   1515 H HD1  . TRP A 1 136 ? -31.981 6.929  2.475   1.00 34.98 ? 102 TRP A HD1  1 
ATOM   1516 H HE1  . TRP A 1 136 ? -33.988 6.411  1.243   1.00 33.55 ? 102 TRP A HE1  1 
ATOM   1517 H HE3  . TRP A 1 136 ? -35.157 9.751  4.913   1.00 29.69 ? 102 TRP A HE3  1 
ATOM   1518 H HZ2  . TRP A 1 136 ? -36.659 7.146  1.315   1.00 31.36 ? 102 TRP A HZ2  1 
ATOM   1519 H HZ3  . TRP A 1 136 ? -37.378 9.774  4.270   1.00 28.34 ? 102 TRP A HZ3  1 
ATOM   1520 H HH2  . TRP A 1 136 ? -38.114 8.489  2.495   1.00 31.93 ? 102 TRP A HH2  1 
ATOM   1521 N N    . TRP A 1 137 ? -30.192 8.406  7.221   1.00 22.98 ? 103 TRP A N    1 
ATOM   1522 C CA   . TRP A 1 137 ? -29.699 9.299  8.260   1.00 21.82 ? 103 TRP A CA   1 
ATOM   1523 C C    . TRP A 1 137 ? -28.235 9.654  8.035   1.00 28.64 ? 103 TRP A C    1 
ATOM   1524 O O    . TRP A 1 137 ? -27.422 8.814  7.641   1.00 25.32 ? 103 TRP A O    1 
ATOM   1525 C CB   . TRP A 1 137 ? -29.875 8.663  9.638   1.00 22.84 ? 103 TRP A CB   1 
ATOM   1526 C CG   . TRP A 1 137 ? -31.309 8.494  10.043  1.00 28.44 ? 103 TRP A CG   1 
ATOM   1527 C CD1  . TRP A 1 137 ? -32.414 8.774  9.291   1.00 25.09 ? 103 TRP A CD1  1 
ATOM   1528 C CD2  . TRP A 1 137 ? -31.793 8.011  11.302  1.00 29.79 ? 103 TRP A CD2  1 
ATOM   1529 N NE1  . TRP A 1 137 ? -33.554 8.490  10.002  1.00 25.49 ? 103 TRP A NE1  1 
ATOM   1530 C CE2  . TRP A 1 137 ? -33.200 8.020  11.240  1.00 26.77 ? 103 TRP A CE2  1 
ATOM   1531 C CE3  . TRP A 1 137 ? -31.172 7.570  12.474  1.00 29.62 ? 103 TRP A CE3  1 
ATOM   1532 C CZ2  . TRP A 1 137 ? -33.997 7.606  12.306  1.00 30.62 ? 103 TRP A CZ2  1 
ATOM   1533 C CZ3  . TRP A 1 137 ? -31.965 7.159  13.531  1.00 29.19 ? 103 TRP A CZ3  1 
ATOM   1534 C CH2  . TRP A 1 137 ? -33.361 7.180  13.440  1.00 28.44 ? 103 TRP A CH2  1 
ATOM   1535 H H    . TRP A 1 137 ? -30.502 7.658  7.512   1.00 27.61 ? 103 TRP A H    1 
ATOM   1536 H HA   . TRP A 1 137 ? -30.213 10.121 8.234   1.00 26.21 ? 103 TRP A HA   1 
ATOM   1537 H HB2  . TRP A 1 137 ? -29.464 7.784  9.631   1.00 27.43 ? 103 TRP A HB2  1 
ATOM   1538 H HB3  . TRP A 1 137 ? -29.444 9.225  10.300  1.00 27.43 ? 103 TRP A HB3  1 
ATOM   1539 H HD1  . TRP A 1 137 ? -32.397 9.108  8.424   1.00 30.14 ? 103 TRP A HD1  1 
ATOM   1540 H HE1  . TRP A 1 137 ? -34.359 8.590  9.717   1.00 30.61 ? 103 TRP A HE1  1 
ATOM   1541 H HE3  . TRP A 1 137 ? -30.245 7.553  12.542  1.00 35.57 ? 103 TRP A HE3  1 
ATOM   1542 H HZ2  . TRP A 1 137 ? -34.925 7.619  12.248  1.00 36.77 ? 103 TRP A HZ2  1 
ATOM   1543 H HZ3  . TRP A 1 137 ? -31.562 6.863  14.315  1.00 35.06 ? 103 TRP A HZ3  1 
ATOM   1544 H HH2  . TRP A 1 137 ? -33.869 6.899  14.167  1.00 34.16 ? 103 TRP A HH2  1 
ATOM   1545 N N    . LEU A 1 138 ? -27.907 10.917 8.293   1.00 25.29 ? 104 LEU A N    1 
ATOM   1546 C CA   . LEU A 1 138 ? -26.541 11.391 8.131   1.00 21.44 ? 104 LEU A CA   1 
ATOM   1547 C C    . LEU A 1 138 ? -25.649 10.810 9.220   1.00 25.58 ? 104 LEU A C    1 
ATOM   1548 O O    . LEU A 1 138 ? -25.978 10.872 10.408  1.00 22.08 ? 104 LEU A O    1 
ATOM   1549 C CB   . LEU A 1 138 ? -26.510 12.916 8.178   1.00 19.61 ? 104 LEU A CB   1 
ATOM   1550 C CG   . LEU A 1 138 ? -25.137 13.578 8.057   1.00 21.45 ? 104 LEU A CG   1 
ATOM   1551 C CD1  . LEU A 1 138 ? -24.460 13.193 6.750   1.00 23.18 ? 104 LEU A CD1  1 
ATOM   1552 C CD2  . LEU A 1 138 ? -25.277 15.086 8.168   1.00 19.73 ? 104 LEU A CD2  1 
ATOM   1553 H H    . LEU A 1 138 ? -28.458 11.518 8.564   1.00 30.38 ? 104 LEU A H    1 
ATOM   1554 H HA   . LEU A 1 138 ? -26.198 11.102 7.271   1.00 25.75 ? 104 LEU A HA   1 
ATOM   1555 H HB2  . LEU A 1 138 ? -27.052 13.250 7.446   1.00 23.56 ? 104 LEU A HB2  1 
ATOM   1556 H HB3  . LEU A 1 138 ? -26.888 13.198 9.025   1.00 23.56 ? 104 LEU A HB3  1 
ATOM   1557 H HG   . LEU A 1 138 ? -24.569 13.268 8.780   1.00 25.77 ? 104 LEU A HG   1 
ATOM   1558 H HD11 . LEU A 1 138 ? -23.648 13.715 6.649   1.00 27.84 ? 104 LEU A HD11 1 
ATOM   1559 H HD12 . LEU A 1 138 ? -24.245 12.248 6.772   1.00 27.84 ? 104 LEU A HD12 1 
ATOM   1560 H HD13 . LEU A 1 138 ? -25.065 13.378 6.014   1.00 27.84 ? 104 LEU A HD13 1 
ATOM   1561 H HD21 . LEU A 1 138 ? -24.393 15.485 8.178   1.00 23.70 ? 104 LEU A HD21 1 
ATOM   1562 H HD22 . LEU A 1 138 ? -25.779 15.414 7.406   1.00 23.70 ? 104 LEU A HD22 1 
ATOM   1563 H HD23 . LEU A 1 138 ? -25.746 15.300 8.990   1.00 23.70 ? 104 LEU A HD23 1 
ATOM   1564 N N    . LYS A 1 139 ? -24.518 10.245 8.811   1.00 23.59 ? 105 LYS A N    1 
ATOM   1565 C CA   . LYS A 1 139 ? -23.529 9.702  9.729   1.00 28.90 ? 105 LYS A CA   1 
ATOM   1566 C C    . LYS A 1 139 ? -22.286 10.580 9.707   1.00 26.61 ? 105 LYS A C    1 
ATOM   1567 O O    . LYS A 1 139 ? -21.899 11.098 8.655   1.00 26.94 ? 105 LYS A O    1 
ATOM   1568 C CB   . LYS A 1 139 ? -23.161 8.262  9.358   1.00 30.87 ? 105 LYS A CB   1 
ATOM   1569 C CG   . LYS A 1 139 ? -24.138 7.216  9.891   1.00 32.68 ? 105 LYS A CG   1 
ATOM   1570 C CD   . LYS A 1 139 ? -24.339 6.046  8.926   1.00 41.65 ? 105 LYS A CD   1 
ATOM   1571 C CE   . LYS A 1 139 ? -25.011 6.464  7.618   1.00 46.07 ? 105 LYS A CE   1 
ATOM   1572 N NZ   . LYS A 1 139 ? -26.476 6.182  7.609   1.00 39.08 ? 105 LYS A NZ   1 
ATOM   1573 H H    . LYS A 1 139 ? -24.297 10.163 7.984   1.00 28.34 ? 105 LYS A H    1 
ATOM   1574 H HA   . LYS A 1 139 ? -23.887 9.695  10.631  1.00 34.71 ? 105 LYS A HA   1 
ATOM   1575 H HB2  . LYS A 1 139 ? -23.144 8.185  8.391   1.00 37.07 ? 105 LYS A HB2  1 
ATOM   1576 H HB3  . LYS A 1 139 ? -22.285 8.061  9.722   1.00 37.07 ? 105 LYS A HB3  1 
ATOM   1577 H HG2  . LYS A 1 139 ? -23.795 6.859  10.726  1.00 39.24 ? 105 LYS A HG2  1 
ATOM   1578 H HG3  . LYS A 1 139 ? -25.000 7.634  10.038  1.00 39.24 ? 105 LYS A HG3  1 
ATOM   1579 H HD2  . LYS A 1 139 ? -23.475 5.662  8.709   1.00 50.00 ? 105 LYS A HD2  1 
ATOM   1580 H HD3  . LYS A 1 139 ? -24.901 5.379  9.351   1.00 50.00 ? 105 LYS A HD3  1 
ATOM   1581 H HE2  . LYS A 1 139 ? -24.888 7.417  7.489   1.00 55.31 ? 105 LYS A HE2  1 
ATOM   1582 H HE3  . LYS A 1 139 ? -24.607 5.975  6.884   1.00 55.31 ? 105 LYS A HE3  1 
ATOM   1583 H HZ1  . LYS A 1 139 ? -26.827 6.418  6.826   1.00 46.92 ? 105 LYS A HZ1  1 
ATOM   1584 H HZ2  . LYS A 1 139 ? -26.620 5.313  7.740   1.00 46.92 ? 105 LYS A HZ2  1 
ATOM   1585 H HZ3  . LYS A 1 139 ? -26.879 6.641  8.256   1.00 46.92 ? 105 LYS A HZ3  1 
ATOM   1586 N N    . LYS A 1 140 ? -21.674 10.755 10.873  1.00 24.69 ? 106 LYS A N    1 
ATOM   1587 C CA   . LYS A 1 140 ? -20.442 11.516 10.989  1.00 24.02 ? 106 LYS A CA   1 
ATOM   1588 C C    . LYS A 1 140 ? -19.236 10.615 10.726  1.00 30.37 ? 106 LYS A C    1 
ATOM   1589 O O    . LYS A 1 140 ? -19.355 9.395  10.593  1.00 27.43 ? 106 LYS A O    1 
ATOM   1590 C CB   . LYS A 1 140 ? -20.341 12.158 12.374  1.00 26.99 ? 106 LYS A CB   1 
ATOM   1591 C CG   . LYS A 1 140 ? -21.379 13.246 12.626  1.00 30.88 ? 106 LYS A CG   1 
ATOM   1592 C CD   . LYS A 1 140 ? -21.217 13.899 13.995  1.00 21.02 ? 106 LYS A CD   1 
ATOM   1593 C CE   . LYS A 1 140 ? -21.366 12.902 15.135  1.00 26.70 ? 106 LYS A CE   1 
ATOM   1594 N NZ   . LYS A 1 140 ? -21.223 13.560 16.464  1.00 34.71 ? 106 LYS A NZ   1 
ATOM   1595 H H    . LYS A 1 140 ? -21.958 10.437 11.620  1.00 29.65 ? 106 LYS A H    1 
ATOM   1596 H HA   . LYS A 1 140 ? -20.440 12.227 10.329  1.00 28.85 ? 106 LYS A HA   1 
ATOM   1597 H HB2  . LYS A 1 140 ? -20.466 11.469 13.046  1.00 32.41 ? 106 LYS A HB2  1 
ATOM   1598 H HB3  . LYS A 1 140 ? -19.463 12.559 12.469  1.00 32.41 ? 106 LYS A HB3  1 
ATOM   1599 H HG2  . LYS A 1 140 ? -21.285 13.937 11.951  1.00 37.08 ? 106 LYS A HG2  1 
ATOM   1600 H HG3  . LYS A 1 140 ? -22.266 12.856 12.581  1.00 37.08 ? 106 LYS A HG3  1 
ATOM   1601 H HD2  . LYS A 1 140 ? -20.334 14.295 14.056  1.00 25.25 ? 106 LYS A HD2  1 
ATOM   1602 H HD3  . LYS A 1 140 ? -21.896 14.583 14.104  1.00 25.25 ? 106 LYS A HD3  1 
ATOM   1603 H HE2  . LYS A 1 140 ? -22.245 12.493 15.091  1.00 32.07 ? 106 LYS A HE2  1 
ATOM   1604 H HE3  . LYS A 1 140 ? -20.680 12.221 15.057  1.00 32.07 ? 106 LYS A HE3  1 
ATOM   1605 H HZ1  . LYS A 1 140 ? -20.397 13.879 16.558  1.00 41.67 ? 106 LYS A HZ1  1 
ATOM   1606 H HZ2  . LYS A 1 140 ? -21.802 14.231 16.535  1.00 41.67 ? 106 LYS A HZ2  1 
ATOM   1607 H HZ3  . LYS A 1 140 ? -21.380 12.972 17.113  1.00 41.67 ? 106 LYS A HZ3  1 
ATOM   1608 N N    . LEU A 1 141 ? -18.057 11.240 10.644  1.00 34.90 ? 107 LEU A N    1 
ATOM   1609 C CA   . LEU A 1 141 ? -16.827 10.484 10.426  1.00 30.84 ? 107 LEU A CA   1 
ATOM   1610 C C    . LEU A 1 141 ? -16.712 9.325  11.407  1.00 33.36 ? 107 LEU A C    1 
ATOM   1611 O O    . LEU A 1 141 ? -16.349 8.207  11.024  1.00 34.09 ? 107 LEU A O    1 
ATOM   1612 C CB   . LEU A 1 141 ? -15.615 11.407 10.560  1.00 30.27 ? 107 LEU A CB   1 
ATOM   1613 C CG   . LEU A 1 141 ? -15.158 12.194 9.329   1.00 27.87 ? 107 LEU A CG   1 
ATOM   1614 C CD1  . LEU A 1 141 ? -14.011 13.119 9.708   1.00 29.42 ? 107 LEU A CD1  1 
ATOM   1615 C CD2  . LEU A 1 141 ? -14.739 11.273 8.191   1.00 31.83 ? 107 LEU A CD2  1 
ATOM   1616 H H    . LEU A 1 141 ? -17.946 12.090 10.710  1.00 41.90 ? 107 LEU A H    1 
ATOM   1617 H HA   . LEU A 1 141 ? -16.838 10.124 9.525   1.00 37.04 ? 107 LEU A HA   1 
ATOM   1618 H HB2  . LEU A 1 141 ? -15.819 12.062 11.246  1.00 36.35 ? 107 LEU A HB2  1 
ATOM   1619 H HB3  . LEU A 1 141 ? -14.861 10.863 10.835  1.00 36.35 ? 107 LEU A HB3  1 
ATOM   1620 H HG   . LEU A 1 141 ? -15.904 12.723 9.007   1.00 33.48 ? 107 LEU A HG   1 
ATOM   1621 H HD11 . LEU A 1 141 ? -13.790 13.677 8.946   1.00 35.34 ? 107 LEU A HD11 1 
ATOM   1622 H HD12 . LEU A 1 141 ? -14.286 13.673 10.455  1.00 35.34 ? 107 LEU A HD12 1 
ATOM   1623 H HD13 . LEU A 1 141 ? -13.243 12.583 9.960   1.00 35.34 ? 107 LEU A HD13 1 
ATOM   1624 H HD21 . LEU A 1 141 ? -14.363 11.808 7.475   1.00 38.23 ? 107 LEU A HD21 1 
ATOM   1625 H HD22 . LEU A 1 141 ? -14.076 10.646 8.519   1.00 38.23 ? 107 LEU A HD22 1 
ATOM   1626 H HD23 . LEU A 1 141 ? -15.519 10.793 7.871   1.00 38.23 ? 107 LEU A HD23 1 
ATOM   1627 N N    . ASP A 1 142 ? -17.028 9.572  12.675  1.00 34.67 ? 108 ASP A N    1 
ATOM   1628 C CA   . ASP A 1 142 ? -16.918 8.575  13.731  1.00 32.07 ? 108 ASP A CA   1 
ATOM   1629 C C    . ASP A 1 142 ? -18.028 7.519  13.699  1.00 33.86 ? 108 ASP A C    1 
ATOM   1630 O O    . ASP A 1 142 ? -18.132 6.748  14.658  1.00 33.87 ? 108 ASP A O    1 
ATOM   1631 C CB   . ASP A 1 142 ? -16.904 9.278  15.092  1.00 32.30 ? 108 ASP A CB   1 
ATOM   1632 C CG   . ASP A 1 142 ? -18.230 9.938  15.426  1.00 36.78 ? 108 ASP A CG   1 
ATOM   1633 O OD1  . ASP A 1 142 ? -19.156 9.891  14.589  1.00 35.84 ? 108 ASP A OD1  1 
ATOM   1634 O OD2  . ASP A 1 142 ? -18.346 10.508 16.532  1.00 34.83 ? 108 ASP A OD2  1 
ATOM   1635 H H    . ASP A 1 142 ? -17.317 10.332 12.955  1.00 41.63 ? 108 ASP A H    1 
ATOM   1636 H HA   . ASP A 1 142 ? -16.079 8.101  13.620  1.00 38.51 ? 108 ASP A HA   1 
ATOM   1637 H HB2  . ASP A 1 142 ? -16.711 8.626  15.784  1.00 38.79 ? 108 ASP A HB2  1 
ATOM   1638 H HB3  . ASP A 1 142 ? -16.220 9.966  15.086  1.00 38.79 ? 108 ASP A HB3  1 
ATOM   1639 N N    . GLY A 1 143 ? -18.854 7.449  12.653  1.00 31.60 ? 109 GLY A N    1 
ATOM   1640 C CA   . GLY A 1 143 ? -19.866 6.418  12.546  1.00 31.52 ? 109 GLY A CA   1 
ATOM   1641 C C    . GLY A 1 143 ? -21.160 6.694  13.281  1.00 31.26 ? 109 GLY A C    1 
ATOM   1642 O O    . GLY A 1 143 ? -22.146 5.983  13.049  1.00 34.07 ? 109 GLY A O    1 
ATOM   1643 H H    . GLY A 1 143 ? -18.842 7.997  11.990  1.00 37.95 ? 109 GLY A H    1 
ATOM   1644 H HA2  . GLY A 1 143 ? -20.083 6.295  11.609  1.00 37.85 ? 109 GLY A HA2  1 
ATOM   1645 H HA3  . GLY A 1 143 ? -19.501 5.591  12.897  1.00 37.85 ? 109 GLY A HA3  1 
ATOM   1646 N N    . ASN A 1 144 ? -21.197 7.691  14.158  1.00 32.42 ? 110 ASN A N    1 
ATOM   1647 C CA   . ASN A 1 144 ? -22.411 8.024  14.887  1.00 33.87 ? 110 ASN A CA   1 
ATOM   1648 C C    . ASN A 1 144 ? -23.292 8.954  14.060  1.00 30.82 ? 110 ASN A C    1 
ATOM   1649 O O    . ASN A 1 144 ? -22.809 9.727  13.228  1.00 22.65 ? 110 ASN A O    1 
ATOM   1650 C CB   . ASN A 1 144 ? -22.074 8.679  16.227  1.00 38.34 ? 110 ASN A CB   1 
ATOM   1651 C CG   . ASN A 1 144 ? -21.591 7.679  17.257  1.00 38.65 ? 110 ASN A CG   1 
ATOM   1652 O OD1  . ASN A 1 144 ? -22.130 6.578  17.369  1.00 41.21 ? 110 ASN A OD1  1 
ATOM   1653 N ND2  . ASN A 1 144 ? -20.570 8.056  18.016  1.00 42.11 ? 110 ASN A ND2  1 
ATOM   1654 H H    . ASN A 1 144 ? -20.526 8.193  14.348  1.00 38.93 ? 110 ASN A H    1 
ATOM   1655 H HA   . ASN A 1 144 ? -22.911 7.213  15.066  1.00 40.68 ? 110 ASN A HA   1 
ATOM   1656 H HB2  . ASN A 1 144 ? -21.372 9.335  16.092  1.00 46.04 ? 110 ASN A HB2  1 
ATOM   1657 H HB3  . ASN A 1 144 ? -22.868 9.112  16.577  1.00 46.04 ? 110 ASN A HB3  1 
ATOM   1658 H HD21 . ASN A 1 144 ? -20.259 7.523  18.615  1.00 50.55 ? 110 ASN A HD21 1 
ATOM   1659 H HD22 . ASN A 1 144 ? -20.218 8.834  17.908  1.00 50.55 ? 110 ASN A HD22 1 
ATOM   1660 N N    . TYR A 1 145 ? -24.597 8.868  14.298  1.00 29.41 ? 111 TYR A N    1 
ATOM   1661 C CA   . TYR A 1 145 ? -25.546 9.683  13.554  1.00 27.00 ? 111 TYR A CA   1 
ATOM   1662 C C    . TYR A 1 145 ? -25.375 11.154 13.905  1.00 23.17 ? 111 TYR A C    1 
ATOM   1663 O O    . TYR A 1 145 ? -25.161 11.515 15.066  1.00 23.78 ? 111 TYR A O    1 
ATOM   1664 C CB   . TYR A 1 145 ? -26.975 9.228  13.847  1.00 27.31 ? 111 TYR A CB   1 
ATOM   1665 C CG   . TYR A 1 145 ? -27.315 7.888  13.238  1.00 26.55 ? 111 TYR A CG   1 
ATOM   1666 C CD1  . TYR A 1 145 ? -27.047 7.626  11.902  1.00 29.84 ? 111 TYR A CD1  1 
ATOM   1667 C CD2  . TYR A 1 145 ? -27.892 6.881  13.999  1.00 28.96 ? 111 TYR A CD2  1 
ATOM   1668 C CE1  . TYR A 1 145 ? -27.348 6.406  11.338  1.00 32.94 ? 111 TYR A CE1  1 
ATOM   1669 C CE2  . TYR A 1 145 ? -28.199 5.655  13.442  1.00 32.38 ? 111 TYR A CE2  1 
ATOM   1670 C CZ   . TYR A 1 145 ? -27.922 5.424  12.110  1.00 33.60 ? 111 TYR A CZ   1 
ATOM   1671 O OH   . TYR A 1 145 ? -28.219 4.207  11.541  1.00 43.56 ? 111 TYR A OH   1 
ATOM   1672 H H    . TYR A 1 145 ? -24.955 8.349  14.883  1.00 35.32 ? 111 TYR A H    1 
ATOM   1673 H HA   . TYR A 1 145 ? -25.387 9.579  12.603  1.00 32.43 ? 111 TYR A HA   1 
ATOM   1674 H HB2  . TYR A 1 145 ? -27.091 9.157  14.807  1.00 32.80 ? 111 TYR A HB2  1 
ATOM   1675 H HB3  . TYR A 1 145 ? -27.592 9.884  13.487  1.00 32.80 ? 111 TYR A HB3  1 
ATOM   1676 H HD1  . TYR A 1 145 ? -26.656 8.287  11.377  1.00 35.83 ? 111 TYR A HD1  1 
ATOM   1677 H HD2  . TYR A 1 145 ? -28.076 7.035  14.898  1.00 34.78 ? 111 TYR A HD2  1 
ATOM   1678 H HE1  . TYR A 1 145 ? -27.164 6.248  10.441  1.00 39.56 ? 111 TYR A HE1  1 
ATOM   1679 H HE2  . TYR A 1 145 ? -28.589 4.989  13.961  1.00 38.88 ? 111 TYR A HE2  1 
ATOM   1680 H HH   . TYR A 1 145 ? -28.342 3.632  12.141  1.00 52.30 ? 111 TYR A HH   1 
ATOM   1681 N N    . ASP A 1 146 ? -25.469 12.006 12.888  1.00 21.47 ? 112 ASP A N    1 
ATOM   1682 C CA   . ASP A 1 146 ? -25.268 13.438 13.065  1.00 20.37 ? 112 ASP A CA   1 
ATOM   1683 C C    . ASP A 1 146 ? -26.527 14.068 13.648  1.00 25.48 ? 112 ASP A C    1 
ATOM   1684 O O    . ASP A 1 146 ? -27.584 14.069 13.006  1.00 22.85 ? 112 ASP A O    1 
ATOM   1685 C CB   . ASP A 1 146 ? -24.911 14.091 11.733  1.00 22.73 ? 112 ASP A CB   1 
ATOM   1686 C CG   . ASP A 1 146 ? -24.377 15.497 11.902  1.00 23.16 ? 112 ASP A CG   1 
ATOM   1687 O OD1  . ASP A 1 146 ? -24.790 16.175 12.865  1.00 29.52 ? 112 ASP A OD1  1 
ATOM   1688 O OD2  . ASP A 1 146 ? -23.552 15.926 11.069  1.00 22.95 ? 112 ASP A OD2  1 
ATOM   1689 H H    . ASP A 1 146 ? -25.649 11.776 12.080  1.00 25.79 ? 112 ASP A H    1 
ATOM   1690 H HA   . ASP A 1 146 ? -24.537 13.583 13.685  1.00 24.47 ? 112 ASP A HA   1 
ATOM   1691 H HB2  . ASP A 1 146 ? -24.229 13.561 11.292  1.00 27.31 ? 112 ASP A HB2  1 
ATOM   1692 H HB3  . ASP A 1 146 ? -25.706 14.136 11.178  1.00 27.31 ? 112 ASP A HB3  1 
ATOM   1693 N N    . TYR A 1 147 ? -26.411 14.605 14.859  1.00 22.10 ? 113 TYR A N    1 
ATOM   1694 C CA   . TYR A 1 147 ? -27.489 15.324 15.523  1.00 25.69 ? 113 TYR A CA   1 
ATOM   1695 C C    . TYR A 1 147 ? -27.071 16.774 15.717  1.00 23.00 ? 113 TYR A C    1 
ATOM   1696 O O    . TYR A 1 147 ? -25.952 17.045 16.166  1.00 24.50 ? 113 TYR A O    1 
ATOM   1697 C CB   . TYR A 1 147 ? -27.818 14.708 16.887  1.00 22.78 ? 113 TYR A CB   1 
ATOM   1698 C CG   . TYR A 1 147 ? -28.624 13.430 16.843  1.00 22.75 ? 113 TYR A CG   1 
ATOM   1699 C CD1  . TYR A 1 147 ? -28.001 12.199 16.695  1.00 30.27 ? 113 TYR A CD1  1 
ATOM   1700 C CD2  . TYR A 1 147 ? -30.005 13.454 16.974  1.00 26.60 ? 113 TYR A CD2  1 
ATOM   1701 C CE1  . TYR A 1 147 ? -28.733 11.027 16.665  1.00 29.20 ? 113 TYR A CE1  1 
ATOM   1702 C CE2  . TYR A 1 147 ? -30.746 12.286 16.946  1.00 29.68 ? 113 TYR A CE2  1 
ATOM   1703 C CZ   . TYR A 1 147 ? -30.104 11.076 16.791  1.00 29.08 ? 113 TYR A CZ   1 
ATOM   1704 O OH   . TYR A 1 147 ? -30.835 9.912  16.762  1.00 35.55 ? 113 TYR A OH   1 
ATOM   1705 H H    . TYR A 1 147 ? -25.693 14.562 15.331  1.00 26.55 ? 113 TYR A H    1 
ATOM   1706 H HA   . TYR A 1 147 ? -28.282 15.290 14.966  1.00 30.85 ? 113 TYR A HA   1 
ATOM   1707 H HB2  . TYR A 1 147 ? -26.984 14.508 17.342  1.00 27.36 ? 113 TYR A HB2  1 
ATOM   1708 H HB3  . TYR A 1 147 ? -28.328 15.354 17.400  1.00 27.36 ? 113 TYR A HB3  1 
ATOM   1709 H HD1  . TYR A 1 147 ? -27.075 12.162 16.615  1.00 36.35 ? 113 TYR A HD1  1 
ATOM   1710 H HD2  . TYR A 1 147 ? -30.440 14.268 17.082  1.00 31.95 ? 113 TYR A HD2  1 
ATOM   1711 H HE1  . TYR A 1 147 ? -28.302 10.210 16.560  1.00 35.07 ? 113 TYR A HE1  1 
ATOM   1712 H HE2  . TYR A 1 147 ? -31.671 12.317 17.031  1.00 35.64 ? 113 TYR A HE2  1 
ATOM   1713 H HH   . TYR A 1 147 ? -31.650 10.082 16.870  1.00 42.68 ? 113 TYR A HH   1 
ATOM   1714 N N    . LYS A 1 148 ? -27.963 17.705 15.376  1.00 16.87 ? 114 LYS A N    1 
ATOM   1715 C CA   . LYS A 1 148 ? -27.792 19.072 15.852  1.00 25.50 ? 114 LYS A CA   1 
ATOM   1716 C C    . LYS A 1 148 ? -28.076 19.142 17.345  1.00 23.74 ? 114 LYS A C    1 
ATOM   1717 O O    . LYS A 1 148 ? -27.307 19.731 18.114  1.00 21.87 ? 114 LYS A O    1 
ATOM   1718 C CB   . LYS A 1 148 ? -28.708 20.024 15.082  1.00 21.05 ? 114 LYS A CB   1 
ATOM   1719 C CG   . LYS A 1 148 ? -28.664 21.463 15.583  1.00 24.59 ? 114 LYS A CG   1 
ATOM   1720 C CD   . LYS A 1 148 ? -29.668 22.340 14.859  1.00 25.07 ? 114 LYS A CD   1 
ATOM   1721 C CE   . LYS A 1 148 ? -29.740 23.724 15.483  1.00 29.21 ? 114 LYS A CE   1 
ATOM   1722 N NZ   . LYS A 1 148 ? -28.873 24.694 14.764  1.00 32.18 ? 114 LYS A NZ   1 
ATOM   1723 H H    . LYS A 1 148 ? -28.656 17.572 14.883  1.00 20.28 ? 114 LYS A H    1 
ATOM   1724 H HA   . LYS A 1 148 ? -26.879 19.357 15.691  1.00 30.62 ? 114 LYS A HA   1 
ATOM   1725 H HB2  . LYS A 1 148 ? -28.440 20.027 14.149  1.00 25.29 ? 114 LYS A HB2  1 
ATOM   1726 H HB3  . LYS A 1 148 ? -29.622 19.710 15.163  1.00 25.29 ? 114 LYS A HB3  1 
ATOM   1727 H HG2  . LYS A 1 148 ? -28.873 21.479 16.530  1.00 29.53 ? 114 LYS A HG2  1 
ATOM   1728 H HG3  . LYS A 1 148 ? -27.778 21.828 15.432  1.00 29.53 ? 114 LYS A HG3  1 
ATOM   1729 H HD2  . LYS A 1 148 ? -29.403 22.435 13.931  1.00 30.12 ? 114 LYS A HD2  1 
ATOM   1730 H HD3  . LYS A 1 148 ? -30.548 21.934 14.913  1.00 30.12 ? 114 LYS A HD3  1 
ATOM   1731 H HE2  . LYS A 1 148 ? -30.654 24.046 15.444  1.00 35.08 ? 114 LYS A HE2  1 
ATOM   1732 H HE3  . LYS A 1 148 ? -29.444 23.676 16.405  1.00 35.08 ? 114 LYS A HE3  1 
ATOM   1733 H HZ1  . LYS A 1 148 ? -28.912 25.489 15.161  1.00 38.65 ? 114 LYS A HZ1  1 
ATOM   1734 H HZ2  . LYS A 1 148 ? -28.030 24.410 14.769  1.00 38.65 ? 114 LYS A HZ2  1 
ATOM   1735 H HZ3  . LYS A 1 148 ? -29.145 24.779 13.921  1.00 38.65 ? 114 LYS A HZ3  1 
ATOM   1736 N N    . SER A 1 149 ? -29.180 18.532 17.770  1.00 20.26 ? 115 SER A N    1 
ATOM   1737 C CA   . SER A 1 149 ? -29.536 18.390 19.171  1.00 23.01 ? 115 SER A CA   1 
ATOM   1738 C C    . SER A 1 149 ? -30.172 17.017 19.349  1.00 23.69 ? 115 SER A C    1 
ATOM   1739 O O    . SER A 1 149 ? -30.380 16.278 18.381  1.00 25.61 ? 115 SER A O    1 
ATOM   1740 C CB   . SER A 1 149 ? -30.469 19.519 19.623  1.00 24.78 ? 115 SER A CB   1 
ATOM   1741 O OG   . SER A 1 149 ? -31.800 19.289 19.195  1.00 34.11 ? 115 SER A OG   1 
ATOM   1742 H H    . SER A 1 149 ? -29.759 18.179 17.241  1.00 24.34 ? 115 SER A H    1 
ATOM   1743 H HA   . SER A 1 149 ? -28.738 18.434 19.722  1.00 27.64 ? 115 SER A HA   1 
ATOM   1744 H HB2  . SER A 1 149 ? -30.455 19.569 20.592  1.00 29.77 ? 115 SER A HB2  1 
ATOM   1745 H HB3  . SER A 1 149 ? -30.157 20.355 19.244  1.00 29.77 ? 115 SER A HB3  1 
ATOM   1746 H HG   . SER A 1 149 ? -32.308 19.883 19.503  1.00 40.96 ? 115 SER A HG   1 
ATOM   1747 N N    . ALA A 1 150 ? -30.485 16.673 20.599  1.00 22.20 ? 116 ALA A N    1 
ATOM   1748 C CA   . ALA A 1 150 ? -30.970 15.328 20.894  1.00 24.32 ? 116 ALA A CA   1 
ATOM   1749 C C    . ALA A 1 150 ? -32.193 14.964 20.061  1.00 25.71 ? 116 ALA A C    1 
ATOM   1750 O O    . ALA A 1 150 ? -32.349 13.803 19.667  1.00 21.59 ? 116 ALA A O    1 
ATOM   1751 C CB   . ALA A 1 150 ? -31.289 15.204 22.385  1.00 27.19 ? 116 ALA A CB   1 
ATOM   1752 H H    . ALA A 1 150 ? -30.426 17.191 21.283  1.00 26.67 ? 116 ALA A H    1 
ATOM   1753 H HA   . ALA A 1 150 ? -30.268 14.694 20.678  1.00 29.21 ? 116 ALA A HA   1 
ATOM   1754 H HB1  . ALA A 1 150 ? -31.617 14.309 22.564  1.00 32.66 ? 116 ALA A HB1  1 
ATOM   1755 H HB2  . ALA A 1 150 ? -30.481 15.370 22.895  1.00 32.66 ? 116 ALA A HB2  1 
ATOM   1756 H HB3  . ALA A 1 150 ? -31.967 15.857 22.617  1.00 32.66 ? 116 ALA A HB3  1 
ATOM   1757 N N    . LYS A 1 151 ? -33.063 15.933 19.777  1.00 23.88 ? 117 LYS A N    1 
ATOM   1758 C CA   . LYS A 1 151 ? -34.313 15.676 19.074  1.00 28.25 ? 117 LYS A CA   1 
ATOM   1759 C C    . LYS A 1 151 ? -34.314 16.170 17.634  1.00 30.11 ? 117 LYS A C    1 
ATOM   1760 O O    . LYS A 1 151 ? -35.351 16.079 16.967  1.00 25.75 ? 117 LYS A O    1 
ATOM   1761 C CB   . LYS A 1 151 ? -35.480 16.326 19.830  1.00 31.90 ? 117 LYS A CB   1 
ATOM   1762 C CG   . LYS A 1 151 ? -36.244 15.383 20.759  1.00 33.16 ? 117 LYS A CG   1 
ATOM   1763 C CD   . LYS A 1 151 ? -36.082 15.779 22.217  1.00 33.25 ? 117 LYS A CD   1 
ATOM   1764 C CE   . LYS A 1 151 ? -37.213 15.235 23.078  1.00 29.63 ? 117 LYS A CE   1 
ATOM   1765 N NZ   . LYS A 1 151 ? -37.235 13.746 23.119  1.00 24.67 ? 117 LYS A NZ   1 
ATOM   1766 H H    . LYS A 1 151 ? -32.947 16.759 19.985  1.00 28.68 ? 117 LYS A H    1 
ATOM   1767 H HA   . LYS A 1 151 ? -34.455 14.716 19.054  1.00 33.93 ? 117 LYS A HA   1 
ATOM   1768 H HB2  . LYS A 1 151 ? -35.131 17.050 20.373  1.00 38.31 ? 117 LYS A HB2  1 
ATOM   1769 H HB3  . LYS A 1 151 ? -36.113 16.672 19.182  1.00 38.31 ? 117 LYS A HB3  1 
ATOM   1770 H HG2  . LYS A 1 151 ? -37.188 15.411 20.538  1.00 39.82 ? 117 LYS A HG2  1 
ATOM   1771 H HG3  . LYS A 1 151 ? -35.904 14.481 20.649  1.00 39.82 ? 117 LYS A HG3  1 
ATOM   1772 H HD2  . LYS A 1 151 ? -35.245 15.424 22.555  1.00 39.93 ? 117 LYS A HD2  1 
ATOM   1773 H HD3  . LYS A 1 151 ? -36.085 16.747 22.288  1.00 39.93 ? 117 LYS A HD3  1 
ATOM   1774 H HE2  . LYS A 1 151 ? -37.105 15.559 23.986  1.00 35.58 ? 117 LYS A HE2  1 
ATOM   1775 H HE3  . LYS A 1 151 ? -38.061 15.538 22.717  1.00 35.58 ? 117 LYS A HE3  1 
ATOM   1776 H HZ1  . LYS A 1 151 ? -37.903 13.466 23.636  1.00 29.63 ? 117 LYS A HZ1  1 
ATOM   1777 H HZ2  . LYS A 1 151 ? -37.348 13.421 22.298  1.00 29.63 ? 117 LYS A HZ2  1 
ATOM   1778 H HZ3  . LYS A 1 151 ? -36.467 13.440 23.448  1.00 29.63 ? 117 LYS A HZ3  1 
ATOM   1779 N N    . VAL A 1 152 ? -33.192 16.684 17.131  1.00 23.61 ? 118 VAL A N    1 
ATOM   1780 C CA   . VAL A 1 152 ? -33.126 17.292 15.804  1.00 22.38 ? 118 VAL A CA   1 
ATOM   1781 C C    . VAL A 1 152 ? -31.936 16.697 15.059  1.00 23.07 ? 118 VAL A C    1 
ATOM   1782 O O    . VAL A 1 152 ? -30.803 17.172 15.201  1.00 19.92 ? 118 VAL A O    1 
ATOM   1783 C CB   . VAL A 1 152 ? -33.017 18.818 15.873  1.00 25.47 ? 118 VAL A CB   1 
ATOM   1784 C CG1  . VAL A 1 152 ? -33.103 19.418 14.482  1.00 22.56 ? 118 VAL A CG1  1 
ATOM   1785 C CG2  . VAL A 1 152 ? -34.104 19.387 16.773  1.00 21.13 ? 118 VAL A CG2  1 
ATOM   1786 H H    . VAL A 1 152 ? -32.441 16.691 17.550  1.00 28.36 ? 118 VAL A H    1 
ATOM   1787 H HA   . VAL A 1 152 ? -33.927 17.045 15.314  1.00 26.89 ? 118 VAL A HA   1 
ATOM   1788 H HB   . VAL A 1 152 ? -32.157 19.057 16.252  1.00 30.59 ? 118 VAL A HB   1 
ATOM   1789 H HG11 . VAL A 1 152 ? -33.158 20.383 14.557  1.00 27.10 ? 118 VAL A HG11 1 
ATOM   1790 H HG12 . VAL A 1 152 ? -32.311 19.169 13.982  1.00 27.10 ? 118 VAL A HG12 1 
ATOM   1791 H HG13 . VAL A 1 152 ? -33.895 19.075 14.039  1.00 27.10 ? 118 VAL A HG13 1 
ATOM   1792 H HG21 . VAL A 1 152 ? -34.137 20.350 16.658  1.00 25.38 ? 118 VAL A HG21 1 
ATOM   1793 H HG22 . VAL A 1 152 ? -34.956 18.995 16.526  1.00 25.38 ? 118 VAL A HG22 1 
ATOM   1794 H HG23 . VAL A 1 152 ? -33.895 19.171 17.695  1.00 25.38 ? 118 VAL A HG23 1 
ATOM   1795 N N    . LYS A 1 153 ? -32.187 15.669 14.255  1.00 21.73 ? 119 LYS A N    1 
ATOM   1796 C CA   . LYS A 1 153 ? -31.159 15.147 13.368  1.00 25.75 ? 119 LYS A CA   1 
ATOM   1797 C C    . LYS A 1 153 ? -30.907 16.118 12.217  1.00 21.26 ? 119 LYS A C    1 
ATOM   1798 O O    . LYS A 1 153 ? -31.731 16.983 11.903  1.00 20.13 ? 119 LYS A O    1 
ATOM   1799 C CB   . LYS A 1 153 ? -31.567 13.786 12.804  1.00 23.78 ? 119 LYS A CB   1 
ATOM   1800 C CG   . LYS A 1 153 ? -31.452 12.632 13.783  1.00 25.95 ? 119 LYS A CG   1 
ATOM   1801 C CD   . LYS A 1 153 ? -31.884 11.324 13.136  1.00 23.00 ? 119 LYS A CD   1 
ATOM   1802 C CE   . LYS A 1 153 ? -33.374 11.081 13.303  1.00 32.98 ? 119 LYS A CE   1 
ATOM   1803 N NZ   . LYS A 1 153 ? -33.715 10.628 14.681  1.00 36.84 ? 119 LYS A NZ   1 
ATOM   1804 H H    . LYS A 1 153 ? -32.941 15.259 14.204  1.00 26.10 ? 119 LYS A H    1 
ATOM   1805 H HA   . LYS A 1 153 ? -30.336 15.034 13.870  1.00 30.92 ? 119 LYS A HA   1 
ATOM   1806 H HB2  . LYS A 1 153 ? -32.492 13.836 12.518  1.00 28.56 ? 119 LYS A HB2  1 
ATOM   1807 H HB3  . LYS A 1 153 ? -30.996 13.583 12.046  1.00 28.56 ? 119 LYS A HB3  1 
ATOM   1808 H HG2  . LYS A 1 153 ? -30.531 12.543 14.071  1.00 31.17 ? 119 LYS A HG2  1 
ATOM   1809 H HG3  . LYS A 1 153 ? -32.024 12.800 14.548  1.00 31.17 ? 119 LYS A HG3  1 
ATOM   1810 H HD2  . LYS A 1 153 ? -31.685 11.354 12.187  1.00 27.63 ? 119 LYS A HD2  1 
ATOM   1811 H HD3  . LYS A 1 153 ? -31.408 10.588 13.551  1.00 27.63 ? 119 LYS A HD3  1 
ATOM   1812 H HE2  . LYS A 1 153 ? -33.853 11.907 13.129  1.00 39.60 ? 119 LYS A HE2  1 
ATOM   1813 H HE3  . LYS A 1 153 ? -33.658 10.395 12.680  1.00 39.60 ? 119 LYS A HE3  1 
ATOM   1814 H HZ1  . LYS A 1 153 ? -34.585 10.448 14.736  1.00 44.24 ? 119 LYS A HZ1  1 
ATOM   1815 H HZ2  . LYS A 1 153 ? -33.255 9.893  14.882  1.00 44.24 ? 119 LYS A HZ2  1 
ATOM   1816 H HZ3  . LYS A 1 153 ? -33.514 11.265 15.270  1.00 44.24 ? 119 LYS A HZ3  1 
ATOM   1817 N N    . ARG A 1 154 ? -29.750 15.964 11.581  1.00 18.07 ? 120 ARG A N    1 
ATOM   1818 C CA   . ARG A 1 154 ? -29.400 16.724 10.391  1.00 19.83 ? 120 ARG A CA   1 
ATOM   1819 C C    . ARG A 1 154 ? -29.433 15.811 9.172   1.00 18.89 ? 120 ARG A C    1 
ATOM   1820 O O    . ARG A 1 154 ? -29.011 14.652 9.239   1.00 20.05 ? 120 ARG A O    1 
ATOM   1821 C CB   . ARG A 1 154 ? -28.017 17.362 10.520  1.00 19.00 ? 120 ARG A CB   1 
ATOM   1822 C CG   . ARG A 1 154 ? -27.874 18.336 11.683  1.00 19.98 ? 120 ARG A CG   1 
ATOM   1823 C CD   . ARG A 1 154 ? -26.421 18.461 12.101  1.00 24.90 ? 120 ARG A CD   1 
ATOM   1824 N NE   . ARG A 1 154 ? -25.827 19.717 11.663  1.00 28.82 ? 120 ARG A NE   1 
ATOM   1825 C CZ   . ARG A 1 154 ? -24.555 19.868 11.317  1.00 21.98 ? 120 ARG A CZ   1 
ATOM   1826 N NH1  . ARG A 1 154 ? -23.705 18.853 11.336  1.00 24.47 ? 120 ARG A NH1  1 
ATOM   1827 N NH2  . ARG A 1 154 ? -24.126 21.067 10.940  1.00 23.45 ? 120 ARG A NH2  1 
ATOM   1828 H H    . ARG A 1 154 ? -29.138 15.412 11.828  1.00 21.71 ? 120 ARG A H    1 
ATOM   1829 H HA   . ARG A 1 154 ? -30.047 17.435 10.264  1.00 23.83 ? 120 ARG A HA   1 
ATOM   1830 H HB2  . ARG A 1 154 ? -27.363 16.657 10.646  1.00 22.82 ? 120 ARG A HB2  1 
ATOM   1831 H HB3  . ARG A 1 154 ? -27.825 17.850 9.704   1.00 22.82 ? 120 ARG A HB3  1 
ATOM   1832 H HG2  . ARG A 1 154 ? -28.195 19.211 11.415  1.00 24.00 ? 120 ARG A HG2  1 
ATOM   1833 H HG3  . ARG A 1 154 ? -28.386 18.013 12.442  1.00 24.00 ? 120 ARG A HG3  1 
ATOM   1834 H HD2  . ARG A 1 154 ? -26.364 18.422 13.068  1.00 29.91 ? 120 ARG A HD2  1 
ATOM   1835 H HD3  . ARG A 1 154 ? -25.914 17.734 11.708  1.00 29.91 ? 120 ARG A HD3  1 
ATOM   1836 H HE   . ARG A 1 154 ? -26.336 20.409 11.625  1.00 34.61 ? 120 ARG A HE   1 
ATOM   1837 H HH11 . ARG A 1 154 ? -23.972 18.072 11.576  1.00 29.39 ? 120 ARG A HH11 1 
ATOM   1838 H HH12 . ARG A 1 154 ? -22.885 18.975 11.108  1.00 29.39 ? 120 ARG A HH12 1 
ATOM   1839 H HH21 . ARG A 1 154 ? -24.670 21.732 10.921  1.00 28.17 ? 120 ARG A HH21 1 
ATOM   1840 H HH22 . ARG A 1 154 ? -23.303 21.177 10.713  1.00 28.17 ? 120 ARG A HH22 1 
ATOM   1841 N N    . TYR A 1 155 ? -29.923 16.347 8.058   1.00 17.43 ? 121 TYR A N    1 
ATOM   1842 C CA   . TYR A 1 155 ? -30.135 15.558 6.855   1.00 20.72 ? 121 TYR A CA   1 
ATOM   1843 C C    . TYR A 1 155 ? -28.830 15.322 6.102   1.00 20.44 ? 121 TYR A C    1 
ATOM   1844 O O    . TYR A 1 155 ? -27.919 16.155 6.109   1.00 21.91 ? 121 TYR A O    1 
ATOM   1845 C CB   . TYR A 1 155 ? -31.113 16.262 5.914   1.00 17.41 ? 121 TYR A CB   1 
ATOM   1846 C CG   . TYR A 1 155 ? -32.528 16.420 6.427   1.00 18.34 ? 121 TYR A CG   1 
ATOM   1847 C CD1  . TYR A 1 155 ? -33.196 15.369 7.042   1.00 16.22 ? 121 TYR A CD1  1 
ATOM   1848 C CD2  . TYR A 1 155 ? -33.208 17.620 6.260   1.00 15.82 ? 121 TYR A CD2  1 
ATOM   1849 C CE1  . TYR A 1 155 ? -34.498 15.517 7.490   1.00 18.15 ? 121 TYR A CE1  1 
ATOM   1850 C CE2  . TYR A 1 155 ? -34.505 17.777 6.704   1.00 15.51 ? 121 TYR A CE2  1 
ATOM   1851 C CZ   . TYR A 1 155 ? -35.146 16.723 7.318   1.00 18.49 ? 121 TYR A CZ   1 
ATOM   1852 O OH   . TYR A 1 155 ? -36.440 16.883 7.760   1.00 21.05 ? 121 TYR A OH   1 
ATOM   1853 H H    . TYR A 1 155 ? -30.143 17.175 7.975   1.00 20.94 ? 121 TYR A H    1 
ATOM   1854 H HA   . TYR A 1 155 ? -30.501 14.699 7.117   1.00 24.89 ? 121 TYR A HA   1 
ATOM   1855 H HB2  . TYR A 1 155 ? -30.773 17.152 5.733   1.00 20.92 ? 121 TYR A HB2  1 
ATOM   1856 H HB3  . TYR A 1 155 ? -31.162 15.752 5.091   1.00 20.92 ? 121 TYR A HB3  1 
ATOM   1857 H HD1  . TYR A 1 155 ? -32.763 14.554 7.154   1.00 19.49 ? 121 TYR A HD1  1 
ATOM   1858 H HD2  . TYR A 1 155 ? -32.781 18.332 5.840   1.00 19.01 ? 121 TYR A HD2  1 
ATOM   1859 H HE1  . TYR A 1 155 ? -34.932 14.807 7.905   1.00 21.80 ? 121 TYR A HE1  1 
ATOM   1860 H HE2  . TYR A 1 155 ? -34.944 18.589 6.589   1.00 18.64 ? 121 TYR A HE2  1 
ATOM   1861 H HH   . TYR A 1 155 ? -36.740 17.625 7.507   1.00 25.29 ? 121 TYR A HH   1 
ATOM   1862 N N    . ASP A 1 156 ? -28.761 14.175 5.423   1.00 17.98 ? 122 ASP A N    1 
ATOM   1863 C CA   . ASP A 1 156 ? -27.681 13.890 4.478   1.00 21.03 ? 122 ASP A CA   1 
ATOM   1864 C C    . ASP A 1 156 ? -28.145 14.344 3.100   1.00 15.64 ? 122 ASP A C    1 
ATOM   1865 O O    . ASP A 1 156 ? -28.777 13.597 2.351   1.00 15.45 ? 122 ASP A O    1 
ATOM   1866 C CB   . ASP A 1 156 ? -27.319 12.411 4.486   1.00 20.45 ? 122 ASP A CB   1 
ATOM   1867 C CG   . ASP A 1 156 ? -26.141 12.096 3.579   1.00 20.31 ? 122 ASP A CG   1 
ATOM   1868 O OD1  . ASP A 1 156 ? -25.624 13.027 2.924   1.00 18.79 ? 122 ASP A OD1  1 
ATOM   1869 O OD2  . ASP A 1 156 ? -25.734 10.916 3.519   1.00 21.74 ? 122 ASP A OD2  1 
ATOM   1870 H H    . ASP A 1 156 ? -29.336 13.539 5.494   1.00 21.61 ? 122 ASP A H    1 
ATOM   1871 H HA   . ASP A 1 156 ? -26.892 14.394 4.732   1.00 25.26 ? 122 ASP A HA   1 
ATOM   1872 H HB2  . ASP A 1 156 ? -27.082 12.147 5.389   1.00 24.56 ? 122 ASP A HB2  1 
ATOM   1873 H HB3  . ASP A 1 156 ? -28.081 11.896 4.179   1.00 24.56 ? 122 ASP A HB3  1 
ATOM   1874 N N    . LEU A 1 157 ? -27.819 15.591 2.757   1.00 20.05 ? 123 LEU A N    1 
ATOM   1875 C CA   . LEU A 1 157 ? -28.241 16.151 1.481   1.00 18.72 ? 123 LEU A CA   1 
ATOM   1876 C C    . LEU A 1 157 ? -27.536 15.516 0.289   1.00 16.75 ? 123 LEU A C    1 
ATOM   1877 O O    . LEU A 1 157 ? -27.988 15.706 -0.846  1.00 13.89 ? 123 LEU A O    1 
ATOM   1878 C CB   . LEU A 1 157 ? -28.009 17.662 1.479   1.00 17.73 ? 123 LEU A CB   1 
ATOM   1879 C CG   . LEU A 1 157 ? -28.966 18.457 2.372   1.00 16.47 ? 123 LEU A CG   1 
ATOM   1880 C CD1  . LEU A 1 157 ? -28.448 19.869 2.594   1.00 27.54 ? 123 LEU A CD1  1 
ATOM   1881 C CD2  . LEU A 1 157 ? -30.360 18.497 1.767   1.00 20.53 ? 123 LEU A CD2  1 
ATOM   1882 H H    . LEU A 1 157 ? -27.356 16.127 3.245   1.00 24.09 ? 123 LEU A H    1 
ATOM   1883 H HA   . LEU A 1 157 ? -29.192 15.993 1.371   1.00 22.49 ? 123 LEU A HA   1 
ATOM   1884 H HB2  . LEU A 1 157 ? -27.106 17.834 1.791   1.00 21.30 ? 123 LEU A HB2  1 
ATOM   1885 H HB3  . LEU A 1 157 ? -28.115 17.989 0.572   1.00 21.30 ? 123 LEU A HB3  1 
ATOM   1886 H HG   . LEU A 1 157 ? -29.023 18.016 3.234   1.00 19.79 ? 123 LEU A HG   1 
ATOM   1887 H HD11 . LEU A 1 157 ? -29.059 20.340 3.181   1.00 33.08 ? 123 LEU A HD11 1 
ATOM   1888 H HD12 . LEU A 1 157 ? -27.568 19.822 3.000   1.00 33.08 ? 123 LEU A HD12 1 
ATOM   1889 H HD13 . LEU A 1 157 ? -28.394 20.323 1.739   1.00 33.08 ? 123 LEU A HD13 1 
ATOM   1890 H HD21 . LEU A 1 157 ? -30.995 18.750 2.454   1.00 24.67 ? 123 LEU A HD21 1 
ATOM   1891 H HD22 . LEU A 1 157 ? -30.373 19.148 1.048   1.00 24.67 ? 123 LEU A HD22 1 
ATOM   1892 H HD23 . LEU A 1 157 ? -30.579 17.617 1.421   1.00 24.67 ? 123 LEU A HD23 1 
ATOM   1893 N N    . SER A 1 158 ? -26.454 14.771 0.509   1.00 15.69 ? 124 SER A N    1 
ATOM   1894 C CA   . SER A 1 158 ? -25.780 14.049 -0.561  1.00 17.67 ? 124 SER A CA   1 
ATOM   1895 C C    . SER A 1 158 ? -26.385 12.671 -0.807  1.00 17.56 ? 124 SER A C    1 
ATOM   1896 O O    . SER A 1 158 ? -25.822 11.889 -1.580  1.00 16.41 ? 124 SER A O    1 
ATOM   1897 C CB   . SER A 1 158 ? -24.287 13.909 -0.251  1.00 16.08 ? 124 SER A CB   1 
ATOM   1898 O OG   . SER A 1 158 ? -24.072 13.075 0.875   1.00 18.59 ? 124 SER A OG   1 
ATOM   1899 H H    . SER A 1 158 ? -26.089 14.669 1.281   1.00 18.85 ? 124 SER A H    1 
ATOM   1900 H HA   . SER A 1 158 ? -25.865 14.564 -1.379  1.00 21.23 ? 124 SER A HA   1 
ATOM   1901 H HB2  . SER A 1 158 ? -23.841 13.521 -1.020  1.00 19.33 ? 124 SER A HB2  1 
ATOM   1902 H HB3  . SER A 1 158 ? -23.921 14.788 -0.065  1.00 19.33 ? 124 SER A HB3  1 
ATOM   1903 H HG   . SER A 1 158 ? -24.458 13.396 1.548   1.00 22.33 ? 124 SER A HG   1 
ATOM   1904 N N    . ASN A 1 159 ? -27.512 12.356 -0.165  1.00 16.56 ? 125 ASN A N    1 
ATOM   1905 C CA   . ASN A 1 159 ? -28.207 11.095 -0.375  1.00 15.32 ? 125 ASN A CA   1 
ATOM   1906 C C    . ASN A 1 159 ? -29.426 11.353 -1.253  1.00 19.09 ? 125 ASN A C    1 
ATOM   1907 O O    . ASN A 1 159 ? -30.438 11.875 -0.760  1.00 16.65 ? 125 ASN A O    1 
ATOM   1908 C CB   . ASN A 1 159 ? -28.625 10.482 0.965   1.00 16.89 ? 125 ASN A CB   1 
ATOM   1909 C CG   . ASN A 1 159 ? -29.229 9.098  0.813   1.00 19.23 ? 125 ASN A CG   1 
ATOM   1910 O OD1  . ASN A 1 159 ? -30.012 8.844  -0.102  1.00 20.16 ? 125 ASN A OD1  1 
ATOM   1911 N ND2  . ASN A 1 159 ? -28.866 8.194  1.715   1.00 20.82 ? 125 ASN A ND2  1 
ATOM   1912 H H    . ASN A 1 159 ? -27.898 12.870 0.407   1.00 19.89 ? 125 ASN A H    1 
ATOM   1913 H HA   . ASN A 1 159 ? -27.621 10.469 -0.828  1.00 18.41 ? 125 ASN A HA   1 
ATOM   1914 H HB2  . ASN A 1 159 ? -27.844 10.408 1.536   1.00 20.30 ? 125 ASN A HB2  1 
ATOM   1915 H HB3  . ASN A 1 159 ? -29.287 11.055 1.383   1.00 20.30 ? 125 ASN A HB3  1 
ATOM   1916 H HD21 . ASN A 1 159 ? -29.181 7.394  1.673   1.00 25.01 ? 125 ASN A HD21 1 
ATOM   1917 H HD22 . ASN A 1 159 ? -28.317 8.408  2.341   1.00 25.01 ? 125 ASN A HD22 1 
ATOM   1918 N N    . PRO A 1 160 ? -29.392 11.013 -2.547  1.00 16.09 ? 126 PRO A N    1 
ATOM   1919 C CA   . PRO A 1 160 ? -30.522 11.371 -3.421  1.00 17.15 ? 126 PRO A CA   1 
ATOM   1920 C C    . PRO A 1 160 ? -31.835 10.721 -3.026  1.00 20.13 ? 126 PRO A C    1 
ATOM   1921 O O    . PRO A 1 160 ? -32.899 11.277 -3.323  1.00 18.57 ? 126 PRO A O    1 
ATOM   1922 C CB   . PRO A 1 160 ? -30.056 10.900 -4.807  1.00 17.88 ? 126 PRO A CB   1 
ATOM   1923 C CG   . PRO A 1 160 ? -28.570 10.801 -4.701  1.00 19.73 ? 126 PRO A CG   1 
ATOM   1924 C CD   . PRO A 1 160 ? -28.318 10.346 -3.301  1.00 17.74 ? 126 PRO A CD   1 
ATOM   1925 H HA   . PRO A 1 160 ? -30.635 12.334 -3.426  1.00 20.61 ? 126 PRO A HA   1 
ATOM   1926 H HB2  . PRO A 1 160 ? -30.448 10.036 -5.011  1.00 21.49 ? 126 PRO A HB2  1 
ATOM   1927 H HB3  . PRO A 1 160 ? -30.314 11.548 -5.481  1.00 21.49 ? 126 PRO A HB3  1 
ATOM   1928 H HG2  . PRO A 1 160 ? -28.234 10.156 -5.342  1.00 23.70 ? 126 PRO A HG2  1 
ATOM   1929 H HG3  . PRO A 1 160 ? -28.168 11.669 -4.862  1.00 23.70 ? 126 PRO A HG3  1 
ATOM   1930 H HD2  . PRO A 1 160 ? -28.390 9.382  -3.231  1.00 21.32 ? 126 PRO A HD2  1 
ATOM   1931 H HD3  . PRO A 1 160 ? -27.445 10.637 -2.993  1.00 21.32 ? 126 PRO A HD3  1 
ATOM   1932 N N    . ALA A 1 161 ? -31.800 9.552  -2.382  1.00 18.83 ? 127 ALA A N    1 
ATOM   1933 C CA   . ALA A 1 161 ? -33.043 8.932  -1.936  1.00 20.22 ? 127 ALA A CA   1 
ATOM   1934 C C    . ALA A 1 161 ? -33.729 9.792  -0.882  1.00 18.95 ? 127 ALA A C    1 
ATOM   1935 O O    . ALA A 1 161 ? -34.949 9.988  -0.928  1.00 18.16 ? 127 ALA A O    1 
ATOM   1936 C CB   . ALA A 1 161 ? -32.772 7.529  -1.397  1.00 21.11 ? 127 ALA A CB   1 
ATOM   1937 H H    . ALA A 1 161 ? -31.087 9.109  -2.197  1.00 22.62 ? 127 ALA A H    1 
ATOM   1938 H HA   . ALA A 1 161 ? -33.642 8.845  -2.694  1.00 24.29 ? 127 ALA A HA   1 
ATOM   1939 H HB1  . ALA A 1 161 ? -33.597 7.161  -1.044  1.00 25.36 ? 127 ALA A HB1  1 
ATOM   1940 H HB2  . ALA A 1 161 ? -32.444 6.971  -2.119  1.00 25.36 ? 127 ALA A HB2  1 
ATOM   1941 H HB3  . ALA A 1 161 ? -32.107 7.583  -0.693  1.00 25.36 ? 127 ALA A HB3  1 
ATOM   1942 N N    . PHE A 1 162 ? -32.962 10.318 0.074   1.00 19.25 ? 128 PHE A N    1 
ATOM   1943 C CA   . PHE A 1 162 ? -33.529 11.276 1.016   1.00 20.74 ? 128 PHE A CA   1 
ATOM   1944 C C    . PHE A 1 162 ? -34.094 12.487 0.285   1.00 14.58 ? 128 PHE A C    1 
ATOM   1945 O O    . PHE A 1 162 ? -35.229 12.907 0.535   1.00 17.85 ? 128 PHE A O    1 
ATOM   1946 C CB   . PHE A 1 162 ? -32.479 11.739 2.022   1.00 17.80 ? 128 PHE A CB   1 
ATOM   1947 C CG   . PHE A 1 162 ? -32.746 13.115 2.548   1.00 15.84 ? 128 PHE A CG   1 
ATOM   1948 C CD1  . PHE A 1 162 ? -33.738 13.323 3.489   1.00 19.29 ? 128 PHE A CD1  1 
ATOM   1949 C CD2  . PHE A 1 162 ? -32.047 14.206 2.066   1.00 16.81 ? 128 PHE A CD2  1 
ATOM   1950 C CE1  . PHE A 1 162 ? -34.005 14.588 3.959   1.00 18.18 ? 128 PHE A CE1  1 
ATOM   1951 C CE2  . PHE A 1 162 ? -32.313 15.475 2.533   1.00 23.42 ? 128 PHE A CE2  1 
ATOM   1952 C CZ   . PHE A 1 162 ? -33.298 15.665 3.476   1.00 18.91 ? 128 PHE A CZ   1 
ATOM   1953 H H    . PHE A 1 162 ? -32.129 10.140 0.195   1.00 23.13 ? 128 PHE A H    1 
ATOM   1954 H HA   . PHE A 1 162 ? -34.241 10.830 1.502   1.00 24.92 ? 128 PHE A HA   1 
ATOM   1955 H HB2  . PHE A 1 162 ? -32.470 11.126 2.774   1.00 21.39 ? 128 PHE A HB2  1 
ATOM   1956 H HB3  . PHE A 1 162 ? -31.610 11.746 1.591   1.00 21.39 ? 128 PHE A HB3  1 
ATOM   1957 H HD1  . PHE A 1 162 ? -34.229 12.601 3.808   1.00 23.18 ? 128 PHE A HD1  1 
ATOM   1958 H HD2  . PHE A 1 162 ? -31.390 14.082 1.419   1.00 20.20 ? 128 PHE A HD2  1 
ATOM   1959 H HE1  . PHE A 1 162 ? -34.664 14.715 4.604   1.00 21.84 ? 128 PHE A HE1  1 
ATOM   1960 H HE2  . PHE A 1 162 ? -31.829 16.201 2.211   1.00 28.13 ? 128 PHE A HE2  1 
ATOM   1961 H HZ   . PHE A 1 162 ? -33.485 16.522 3.786   1.00 22.72 ? 128 PHE A HZ   1 
ATOM   1962 N N    . ARG A 1 163 ? -33.299 13.075 -0.614  1.00 15.59 ? 129 ARG A N    1 
ATOM   1963 C CA   . ARG A 1 163 ? -33.727 14.290 -1.299  1.00 18.83 ? 129 ARG A CA   1 
ATOM   1964 C C    . ARG A 1 163 ? -35.066 14.087 -1.995  1.00 18.62 ? 129 ARG A C    1 
ATOM   1965 O O    . ARG A 1 163 ? -35.946 14.953 -1.927  1.00 15.88 ? 129 ARG A O    1 
ATOM   1966 C CB   . ARG A 1 163 ? -32.661 14.731 -2.302  1.00 15.77 ? 129 ARG A CB   1 
ATOM   1967 C CG   . ARG A 1 163 ? -31.412 15.322 -1.659  1.00 15.85 ? 129 ARG A CG   1 
ATOM   1968 C CD   . ARG A 1 163 ? -30.717 16.312 -2.581  1.00 18.55 ? 129 ARG A CD   1 
ATOM   1969 N NE   . ARG A 1 163 ? -30.522 15.783 -3.926  1.00 18.20 ? 129 ARG A NE   1 
ATOM   1970 C CZ   . ARG A 1 163 ? -29.442 15.126 -4.332  1.00 18.14 ? 129 ARG A CZ   1 
ATOM   1971 N NH1  . ARG A 1 163 ? -28.440 14.861 -3.508  1.00 15.87 ? 129 ARG A NH1  1 
ATOM   1972 N NH2  . ARG A 1 163 ? -29.365 14.726 -5.597  1.00 18.06 ? 129 ARG A NH2  1 
ATOM   1973 H H    . ARG A 1 163 ? -32.519 12.793 -0.840  1.00 18.73 ? 129 ARG A H    1 
ATOM   1974 H HA   . ARG A 1 163 ? -33.833 14.998 -0.644  1.00 22.62 ? 129 ARG A HA   1 
ATOM   1975 H HB2  . ARG A 1 163 ? -32.388 13.961 -2.824  1.00 18.96 ? 129 ARG A HB2  1 
ATOM   1976 H HB3  . ARG A 1 163 ? -33.042 15.408 -2.883  1.00 18.96 ? 129 ARG A HB3  1 
ATOM   1977 H HG2  . ARG A 1 163 ? -31.660 15.787 -0.845  1.00 19.04 ? 129 ARG A HG2  1 
ATOM   1978 H HG3  . ARG A 1 163 ? -30.788 14.607 -1.456  1.00 19.04 ? 129 ARG A HG3  1 
ATOM   1979 H HD2  . ARG A 1 163 ? -31.257 17.115 -2.649  1.00 22.29 ? 129 ARG A HD2  1 
ATOM   1980 H HD3  . ARG A 1 163 ? -29.845 16.529 -2.214  1.00 22.29 ? 129 ARG A HD3  1 
ATOM   1981 H HE   . ARG A 1 163 ? -31.152 15.905 -4.498  1.00 21.86 ? 129 ARG A HE   1 
ATOM   1982 H HH11 . ARG A 1 163 ? -28.480 15.117 -2.687  1.00 19.07 ? 129 ARG A HH11 1 
ATOM   1983 H HH12 . ARG A 1 163 ? -27.751 14.434 -3.793  1.00 19.07 ? 129 ARG A HH12 1 
ATOM   1984 H HH21 . ARG A 1 163 ? -30.009 14.893 -6.142  1.00 21.70 ? 129 ARG A HH21 1 
ATOM   1985 H HH22 . ARG A 1 163 ? -28.670 14.299 -5.872  1.00 21.70 ? 129 ARG A HH22 1 
ATOM   1986 N N    . LYS A 1 164 ? -35.244 12.944 -2.663  1.00 15.53 ? 130 LYS A N    1 
ATOM   1987 C CA   . LYS A 1 164 ? -36.517 12.666 -3.320  1.00 16.22 ? 130 LYS A CA   1 
ATOM   1988 C C    . LYS A 1 164 ? -37.667 12.697 -2.321  1.00 16.71 ? 130 LYS A C    1 
ATOM   1989 O O    . LYS A 1 164 ? -38.743 13.230 -2.617  1.00 16.42 ? 130 LYS A O    1 
ATOM   1990 C CB   . LYS A 1 164 ? -36.460 11.311 -4.025  1.00 21.56 ? 130 LYS A CB   1 
ATOM   1991 C CG   . LYS A 1 164 ? -37.712 10.984 -4.829  1.00 23.82 ? 130 LYS A CG   1 
ATOM   1992 C CD   . LYS A 1 164 ? -37.735 9.530  -5.274  1.00 30.73 ? 130 LYS A CD   1 
ATOM   1993 C CE   . LYS A 1 164 ? -39.002 9.216  -6.052  1.00 39.00 ? 130 LYS A CE   1 
ATOM   1994 N NZ   . LYS A 1 164 ? -39.100 10.022 -7.301  1.00 42.97 ? 130 LYS A NZ   1 
ATOM   1995 H H    . LYS A 1 164 ? -34.652 12.326 -2.748  1.00 18.67 ? 130 LYS A H    1 
ATOM   1996 H HA   . LYS A 1 164 ? -36.678 13.348 -3.990  1.00 19.49 ? 130 LYS A HA   1 
ATOM   1997 H HB2  . LYS A 1 164 ? -35.707 11.309 -4.636  1.00 25.90 ? 130 LYS A HB2  1 
ATOM   1998 H HB3  . LYS A 1 164 ? -36.347 10.616 -3.357  1.00 25.90 ? 130 LYS A HB3  1 
ATOM   1999 H HG2  . LYS A 1 164 ? -38.495 11.146 -4.281  1.00 28.61 ? 130 LYS A HG2  1 
ATOM   2000 H HG3  . LYS A 1 164 ? -37.739 11.544 -5.621  1.00 28.61 ? 130 LYS A HG3  1 
ATOM   2001 H HD2  . LYS A 1 164 ? -36.972 9.356  -5.847  1.00 36.90 ? 130 LYS A HD2  1 
ATOM   2002 H HD3  . LYS A 1 164 ? -37.703 8.954  -4.494  1.00 36.90 ? 130 LYS A HD3  1 
ATOM   2003 H HE2  . LYS A 1 164 ? -39.003 8.277  -6.296  1.00 46.82 ? 130 LYS A HE2  1 
ATOM   2004 H HE3  . LYS A 1 164 ? -39.774 9.416  -5.500  1.00 46.82 ? 130 LYS A HE3  1 
ATOM   2005 H HZ1  . LYS A 1 164 ? -39.828 9.788  -7.758  1.00 51.59 ? 130 LYS A HZ1  1 
ATOM   2006 H HZ2  . LYS A 1 164 ? -39.150 10.888 -7.101  1.00 51.59 ? 130 LYS A HZ2  1 
ATOM   2007 H HZ3  . LYS A 1 164 ? -38.383 9.883  -7.810  1.00 51.59 ? 130 LYS A HZ3  1 
ATOM   2008 N N    . TRP A 1 165 ? -37.463 12.119 -1.137  1.00 16.49 ? 131 TRP A N    1 
ATOM   2009 C CA   . TRP A 1 165 ? -38.496 12.166 -0.109  1.00 18.03 ? 131 TRP A CA   1 
ATOM   2010 C C    . TRP A 1 165 ? -38.706 13.589 0.390   1.00 16.32 ? 131 TRP A C    1 
ATOM   2011 O O    . TRP A 1 165 ? -39.848 14.028 0.573   1.00 15.87 ? 131 TRP A O    1 
ATOM   2012 C CB   . TRP A 1 165 ? -38.122 11.251 1.054   1.00 14.75 ? 131 TRP A CB   1 
ATOM   2013 C CG   . TRP A 1 165 ? -39.015 11.430 2.229   1.00 17.20 ? 131 TRP A CG   1 
ATOM   2014 C CD1  . TRP A 1 165 ? -40.220 10.828 2.441   1.00 21.42 ? 131 TRP A CD1  1 
ATOM   2015 C CD2  . TRP A 1 165 ? -38.788 12.284 3.357   1.00 18.87 ? 131 TRP A CD2  1 
ATOM   2016 N NE1  . TRP A 1 165 ? -40.755 11.249 3.634   1.00 21.39 ? 131 TRP A NE1  1 
ATOM   2017 C CE2  . TRP A 1 165 ? -39.895 12.143 4.216   1.00 19.44 ? 131 TRP A CE2  1 
ATOM   2018 C CE3  . TRP A 1 165 ? -37.756 13.152 3.724   1.00 16.51 ? 131 TRP A CE3  1 
ATOM   2019 C CZ2  . TRP A 1 165 ? -39.999 12.836 5.420   1.00 21.92 ? 131 TRP A CZ2  1 
ATOM   2020 C CZ3  . TRP A 1 165 ? -37.860 13.838 4.921   1.00 19.33 ? 131 TRP A CZ3  1 
ATOM   2021 C CH2  . TRP A 1 165 ? -38.973 13.678 5.753   1.00 18.17 ? 131 TRP A CH2  1 
ATOM   2022 H H    . TRP A 1 165 ? -36.747 11.700 -0.909  1.00 19.81 ? 131 TRP A H    1 
ATOM   2023 H HA   . TRP A 1 165 ? -39.329 11.848 -0.491  1.00 21.66 ? 131 TRP A HA   1 
ATOM   2024 H HB2  . TRP A 1 165 ? -38.187 10.328 0.764   1.00 17.73 ? 131 TRP A HB2  1 
ATOM   2025 H HB3  . TRP A 1 165 ? -37.214 11.448 1.332   1.00 17.73 ? 131 TRP A HB3  1 
ATOM   2026 H HD1  . TRP A 1 165 ? -40.621 10.221 1.862   1.00 25.74 ? 131 TRP A HD1  1 
ATOM   2027 H HE1  . TRP A 1 165 ? -41.507 10.992 3.963   1.00 25.70 ? 131 TRP A HE1  1 
ATOM   2028 H HE3  . TRP A 1 165 ? -37.014 13.265 3.175   1.00 19.84 ? 131 TRP A HE3  1 
ATOM   2029 H HZ2  . TRP A 1 165 ? -40.737 12.730 5.976   1.00 26.33 ? 131 TRP A HZ2  1 
ATOM   2030 H HZ3  . TRP A 1 165 ? -37.179 14.417 5.177   1.00 23.23 ? 131 TRP A HZ3  1 
ATOM   2031 H HH2  . TRP A 1 165 ? -39.017 14.154 6.550   1.00 21.83 ? 131 TRP A HH2  1 
ATOM   2032 N N    . TRP A 1 166 ? -37.614 14.318 0.626   1.00 12.89 ? 132 TRP A N    1 
ATOM   2033 C CA   . TRP A 1 166 ? -37.727 15.695 1.092   1.00 15.93 ? 132 TRP A CA   1 
ATOM   2034 C C    . TRP A 1 166 ? -38.535 16.538 0.117   1.00 18.79 ? 132 TRP A C    1 
ATOM   2035 O O    . TRP A 1 166 ? -39.390 17.332 0.527   1.00 15.42 ? 132 TRP A O    1 
ATOM   2036 C CB   . TRP A 1 166 ? -36.332 16.288 1.288   1.00 16.56 ? 132 TRP A CB   1 
ATOM   2037 C CG   . TRP A 1 166 ? -36.319 17.597 2.015   1.00 15.51 ? 132 TRP A CG   1 
ATOM   2038 C CD1  . TRP A 1 166 ? -36.098 17.792 3.346   1.00 15.70 ? 132 TRP A CD1  1 
ATOM   2039 C CD2  . TRP A 1 166 ? -36.524 18.897 1.447   1.00 14.37 ? 132 TRP A CD2  1 
ATOM   2040 N NE1  . TRP A 1 166 ? -36.155 19.132 3.643   1.00 14.85 ? 132 TRP A NE1  1 
ATOM   2041 C CE2  . TRP A 1 166 ? -36.412 19.832 2.494   1.00 14.80 ? 132 TRP A CE2  1 
ATOM   2042 C CE3  . TRP A 1 166 ? -36.791 19.360 0.154   1.00 16.70 ? 132 TRP A CE3  1 
ATOM   2043 C CZ2  . TRP A 1 166 ? -36.565 21.204 2.291   1.00 14.19 ? 132 TRP A CZ2  1 
ATOM   2044 C CZ3  . TRP A 1 166 ? -36.940 20.721 -0.046  1.00 17.05 ? 132 TRP A CZ3  1 
ATOM   2045 C CH2  . TRP A 1 166 ? -36.828 21.627 1.017   1.00 16.10 ? 132 TRP A CH2  1 
ATOM   2046 H H    . TRP A 1 166 ? -36.806 14.041 0.524   1.00 15.49 ? 132 TRP A H    1 
ATOM   2047 H HA   . TRP A 1 166 ? -38.184 15.704 1.948   1.00 19.15 ? 132 TRP A HA   1 
ATOM   2048 H HB2  . TRP A 1 166 ? -35.798 15.662 1.801   1.00 19.90 ? 132 TRP A HB2  1 
ATOM   2049 H HB3  . TRP A 1 166 ? -35.931 16.431 0.417   1.00 19.90 ? 132 TRP A HB3  1 
ATOM   2050 H HD1  . TRP A 1 166 ? -35.933 17.117 3.963   1.00 18.87 ? 132 TRP A HD1  1 
ATOM   2051 H HE1  . TRP A 1 166 ? -36.046 19.476 4.424   1.00 17.84 ? 132 TRP A HE1  1 
ATOM   2052 H HE3  . TRP A 1 166 ? -36.867 18.765 -0.557  1.00 20.06 ? 132 TRP A HE3  1 
ATOM   2053 H HZ2  . TRP A 1 166 ? -36.491 21.808 2.994   1.00 17.05 ? 132 TRP A HZ2  1 
ATOM   2054 H HZ3  . TRP A 1 166 ? -37.117 21.040 -0.902  1.00 20.49 ? 132 TRP A HZ3  1 
ATOM   2055 H HH2  . TRP A 1 166 ? -36.935 22.536 0.853   1.00 19.35 ? 132 TRP A HH2  1 
ATOM   2056 N N    . VAL A 1 167 ? -38.281 16.375 -1.182  1.00 20.61 ? 133 VAL A N    1 
ATOM   2057 C CA   . VAL A 1 167 ? -38.996 17.161 -2.181  1.00 16.20 ? 133 VAL A CA   1 
ATOM   2058 C C    . VAL A 1 167 ? -40.470 16.779 -2.204  1.00 15.16 ? 133 VAL A C    1 
ATOM   2059 O O    . VAL A 1 167 ? -41.346 17.641 -2.354  1.00 15.16 ? 133 VAL A O    1 
ATOM   2060 C CB   . VAL A 1 167 ? -38.339 16.985 -3.562  1.00 14.38 ? 133 VAL A CB   1 
ATOM   2061 C CG1  . VAL A 1 167 ? -39.133 17.717 -4.627  1.00 17.40 ? 133 VAL A CG1  1 
ATOM   2062 C CG2  . VAL A 1 167 ? -36.899 17.483 -3.535  1.00 16.77 ? 133 VAL A CG2  1 
ATOM   2063 H H    . VAL A 1 167 ? -37.706 15.822 -1.506  1.00 24.76 ? 133 VAL A H    1 
ATOM   2064 H HA   . VAL A 1 167 ? -38.937 18.099 -1.938  1.00 19.46 ? 133 VAL A HA   1 
ATOM   2065 H HB   . VAL A 1 167 ? -38.330 16.041 -3.785  1.00 17.28 ? 133 VAL A HB   1 
ATOM   2066 H HG11 . VAL A 1 167 ? -38.597 17.779 -5.434  1.00 20.90 ? 133 VAL A HG11 1 
ATOM   2067 H HG12 . VAL A 1 167 ? -39.948 17.224 -4.809  1.00 20.90 ? 133 VAL A HG12 1 
ATOM   2068 H HG13 . VAL A 1 167 ? -39.349 18.606 -4.305  1.00 20.90 ? 133 VAL A HG13 1 
ATOM   2069 H HG21 . VAL A 1 167 ? -36.465 17.242 -4.369  1.00 20.15 ? 133 VAL A HG21 1 
ATOM   2070 H HG22 . VAL A 1 167 ? -36.900 18.448 -3.430  1.00 20.15 ? 133 VAL A HG22 1 
ATOM   2071 H HG23 . VAL A 1 167 ? -36.435 17.070 -2.790  1.00 20.15 ? 133 VAL A HG23 1 
ATOM   2072 N N    . SER A 1 168 ? -40.771 15.487 -2.048  1.00 14.73 ? 134 SER A N    1 
ATOM   2073 C CA   . SER A 1 168 ? -42.162 15.043 -2.067  1.00 18.17 ? 134 SER A CA   1 
ATOM   2074 C C    . SER A 1 168 ? -42.983 15.750 -0.995  1.00 14.70 ? 134 SER A C    1 
ATOM   2075 O O    . SER A 1 168 ? -44.159 16.066 -1.211  1.00 15.12 ? 134 SER A O    1 
ATOM   2076 C CB   . SER A 1 168 ? -42.231 13.526 -1.884  1.00 19.69 ? 134 SER A CB   1 
ATOM   2077 O OG   . SER A 1 168 ? -42.021 13.160 -0.532  1.00 21.91 ? 134 SER A OG   1 
ATOM   2078 H H    . SER A 1 168 ? -40.196 14.858 -1.931  1.00 17.70 ? 134 SER A H    1 
ATOM   2079 H HA   . SER A 1 168 ? -42.546 15.260 -2.931  1.00 21.83 ? 134 SER A HA   1 
ATOM   2080 H HB2  . SER A 1 168 ? -43.108 13.216 -2.160  1.00 23.66 ? 134 SER A HB2  1 
ATOM   2081 H HB3  . SER A 1 168 ? -41.546 13.112 -2.431  1.00 23.66 ? 134 SER A HB3  1 
ATOM   2082 H HG   . SER A 1 168 ? -41.260 13.411 -0.281  1.00 26.32 ? 134 SER A HG   1 
ATOM   2083 N N    . ILE A 1 169 ? -42.383 16.006 0.169   1.00 16.58 ? 135 ILE A N    1 
ATOM   2084 C CA   . ILE A 1 169 ? -43.094 16.717 1.229   1.00 15.87 ? 135 ILE A CA   1 
ATOM   2085 C C    . ILE A 1 169 ? -43.435 18.130 0.774   1.00 18.81 ? 135 ILE A C    1 
ATOM   2086 O O    . ILE A 1 169 ? -44.579 18.584 0.899   1.00 19.03 ? 135 ILE A O    1 
ATOM   2087 C CB   . ILE A 1 169 ? -42.261 16.728 2.524   1.00 16.00 ? 135 ILE A CB   1 
ATOM   2088 C CG1  . ILE A 1 169 ? -41.974 15.298 2.997   1.00 13.62 ? 135 ILE A CG1  1 
ATOM   2089 C CG2  . ILE A 1 169 ? -42.976 17.523 3.611   1.00 13.88 ? 135 ILE A CG2  1 
ATOM   2090 C CD1  . ILE A 1 169 ? -43.210 14.435 3.179   1.00 16.69 ? 135 ILE A CD1  1 
ATOM   2091 H H    . ILE A 1 169 ? -41.577 15.781 0.367   1.00 19.92 ? 135 ILE A H    1 
ATOM   2092 H HA   . ILE A 1 169 ? -43.924 16.250 1.411   1.00 19.08 ? 135 ILE A HA   1 
ATOM   2093 H HB   . ILE A 1 169 ? -41.412 17.158 2.334   1.00 19.23 ? 135 ILE A HB   1 
ATOM   2094 H HG12 . ILE A 1 169 ? -41.408 14.863 2.341   1.00 16.37 ? 135 ILE A HG12 1 
ATOM   2095 H HG13 . ILE A 1 169 ? -41.519 15.341 3.853   1.00 16.37 ? 135 ILE A HG13 1 
ATOM   2096 H HG21 . ILE A 1 169 ? -42.583 17.305 4.471   1.00 16.68 ? 135 ILE A HG21 1 
ATOM   2097 H HG22 . ILE A 1 169 ? -42.871 18.470 3.430   1.00 16.68 ? 135 ILE A HG22 1 
ATOM   2098 H HG23 . ILE A 1 169 ? -43.917 17.287 3.608   1.00 16.68 ? 135 ILE A HG23 1 
ATOM   2099 H HD11 . ILE A 1 169 ? -42.965 13.630 3.661   1.00 20.05 ? 135 ILE A HD11 1 
ATOM   2100 H HD12 . ILE A 1 169 ? -43.872 14.934 3.684   1.00 20.05 ? 135 ILE A HD12 1 
ATOM   2101 H HD13 . ILE A 1 169 ? -43.566 14.204 2.307   1.00 20.05 ? 135 ILE A HD13 1 
ATOM   2102 N N    . ALA A 1 170 ? -42.445 18.849 0.241   1.00 16.14 ? 136 ALA A N    1 
ATOM   2103 C CA   . ALA A 1 170 ? -42.705 20.192 -0.266  1.00 15.15 ? 136 ALA A CA   1 
ATOM   2104 C C    . ALA A 1 170 ? -43.667 20.154 -1.449  1.00 18.53 ? 136 ALA A C    1 
ATOM   2105 O O    . ALA A 1 170 ? -44.534 21.026 -1.585  1.00 14.41 ? 136 ALA A O    1 
ATOM   2106 C CB   . ALA A 1 170 ? -41.392 20.864 -0.663  1.00 18.46 ? 136 ALA A CB   1 
ATOM   2107 H H    . ALA A 1 170 ? -41.630 18.587 0.163   1.00 19.39 ? 136 ALA A H    1 
ATOM   2108 H HA   . ALA A 1 170 ? -43.114 20.721 0.436   1.00 18.21 ? 136 ALA A HA   1 
ATOM   2109 H HB1  . ALA A 1 170 ? -41.581 21.756 -0.994  1.00 22.18 ? 136 ALA A HB1  1 
ATOM   2110 H HB2  . ALA A 1 170 ? -40.816 20.915 0.116   1.00 22.18 ? 136 ALA A HB2  1 
ATOM   2111 H HB3  . ALA A 1 170 ? -40.964 20.337 -1.356  1.00 22.18 ? 136 ALA A HB3  1 
ATOM   2112 N N    . LYS A 1 171 ? -43.534 19.146 -2.312  1.00 18.90 ? 137 LYS A N    1 
ATOM   2113 C CA   . LYS A 1 171 ? -44.414 19.045 -3.471  1.00 18.77 ? 137 LYS A CA   1 
ATOM   2114 C C    . LYS A 1 171 ? -45.864 18.851 -3.046  1.00 19.10 ? 137 LYS A C    1 
ATOM   2115 O O    . LYS A 1 171 ? -46.774 19.468 -3.614  1.00 18.27 ? 137 LYS A O    1 
ATOM   2116 C CB   . LYS A 1 171 ? -43.963 17.894 -4.369  1.00 20.01 ? 137 LYS A CB   1 
ATOM   2117 C CG   . LYS A 1 171 ? -44.561 17.925 -5.763  1.00 22.15 ? 137 LYS A CG   1 
ATOM   2118 C CD   . LYS A 1 171 ? -45.626 16.863 -5.932  1.00 25.93 ? 137 LYS A CD   1 
ATOM   2119 C CE   . LYS A 1 171 ? -46.195 16.876 -7.340  1.00 28.37 ? 137 LYS A CE   1 
ATOM   2120 N NZ   . LYS A 1 171 ? -47.415 16.030 -7.447  1.00 39.32 ? 137 LYS A NZ   1 
ATOM   2121 H H    . LYS A 1 171 ? -42.950 18.518 -2.250  1.00 22.70 ? 137 LYS A H    1 
ATOM   2122 H HA   . LYS A 1 171 ? -44.357 19.869 -3.981  1.00 22.55 ? 137 LYS A HA   1 
ATOM   2123 H HB2  . LYS A 1 171 ? -42.998 17.931 -4.461  1.00 24.04 ? 137 LYS A HB2  1 
ATOM   2124 H HB3  . LYS A 1 171 ? -44.225 17.056 -3.955  1.00 24.04 ? 137 LYS A HB3  1 
ATOM   2125 H HG2  . LYS A 1 171 ? -44.966 18.792 -5.920  1.00 26.61 ? 137 LYS A HG2  1 
ATOM   2126 H HG3  . LYS A 1 171 ? -43.862 17.762 -6.416  1.00 26.61 ? 137 LYS A HG3  1 
ATOM   2127 H HD2  . LYS A 1 171 ? -45.240 15.989 -5.766  1.00 31.14 ? 137 LYS A HD2  1 
ATOM   2128 H HD3  . LYS A 1 171 ? -46.349 17.030 -5.308  1.00 31.14 ? 137 LYS A HD3  1 
ATOM   2129 H HE2  . LYS A 1 171 ? -46.434 17.785 -7.581  1.00 34.07 ? 137 LYS A HE2  1 
ATOM   2130 H HE3  . LYS A 1 171 ? -45.531 16.532 -7.958  1.00 34.07 ? 137 LYS A HE3  1 
ATOM   2131 H HZ1  . LYS A 1 171 ? -47.742 16.069 -8.273  1.00 47.21 ? 137 LYS A HZ1  1 
ATOM   2132 H HZ2  . LYS A 1 171 ? -47.216 15.184 -7.255  1.00 47.21 ? 137 LYS A HZ2  1 
ATOM   2133 H HZ3  . LYS A 1 171 ? -48.036 16.317 -6.877  1.00 47.21 ? 137 LYS A HZ3  1 
ATOM   2134 N N    . LYS A 1 172 ? -46.101 17.993 -2.052  1.00 15.44 ? 138 LYS A N    1 
ATOM   2135 C CA   . LYS A 1 172 ? -47.464 17.761 -1.588  1.00 18.03 ? 138 LYS A CA   1 
ATOM   2136 C C    . LYS A 1 172 ? -48.067 19.029 -0.996  1.00 20.62 ? 138 LYS A C    1 
ATOM   2137 O O    . LYS A 1 172 ? -49.247 19.326 -1.213  1.00 19.77 ? 138 LYS A O    1 
ATOM   2138 C CB   . LYS A 1 172 ? -47.480 16.632 -0.558  1.00 18.88 ? 138 LYS A CB   1 
ATOM   2139 C CG   . LYS A 1 172 ? -48.845 16.369 0.060   1.00 27.60 ? 138 LYS A CG   1 
ATOM   2140 C CD   . LYS A 1 172 ? -48.868 15.046 0.810   1.00 48.82 ? 138 LYS A CD   1 
ATOM   2141 C CE   . LYS A 1 172 ? -49.567 15.176 2.155   1.00 46.44 ? 138 LYS A CE   1 
ATOM   2142 N NZ   . LYS A 1 172 ? -51.001 15.551 2.007   1.00 48.80 ? 138 LYS A NZ   1 
ATOM   2143 H H    . LYS A 1 172 ? -45.498 17.541 -1.637  1.00 18.56 ? 138 LYS A H    1 
ATOM   2144 H HA   . LYS A 1 172 ? -48.011 17.491 -2.342  1.00 21.66 ? 138 LYS A HA   1 
ATOM   2145 H HB2  . LYS A 1 172 ? -47.191 15.813 -0.992  1.00 22.69 ? 138 LYS A HB2  1 
ATOM   2146 H HB3  . LYS A 1 172 ? -46.870 16.859 0.161   1.00 22.69 ? 138 LYS A HB3  1 
ATOM   2147 H HG2  . LYS A 1 172 ? -49.057 17.079 0.686   1.00 33.15 ? 138 LYS A HG2  1 
ATOM   2148 H HG3  . LYS A 1 172 ? -49.515 16.334 -0.641  1.00 33.15 ? 138 LYS A HG3  1 
ATOM   2149 H HD2  . LYS A 1 172 ? -49.344 14.386 0.282   1.00 58.61 ? 138 LYS A HD2  1 
ATOM   2150 H HD3  . LYS A 1 172 ? -47.957 14.751 0.968   1.00 58.61 ? 138 LYS A HD3  1 
ATOM   2151 H HE2  . LYS A 1 172 ? -49.523 14.326 2.620   1.00 55.75 ? 138 LYS A HE2  1 
ATOM   2152 H HE3  . LYS A 1 172 ? -49.127 15.864 2.678   1.00 55.75 ? 138 LYS A HE3  1 
ATOM   2153 H HZ1  . LYS A 1 172 ? -51.382 15.616 2.808   1.00 58.59 ? 138 LYS A HZ1  1 
ATOM   2154 H HZ2  . LYS A 1 172 ? -51.069 16.334 1.590   1.00 58.59 ? 138 LYS A HZ2  1 
ATOM   2155 H HZ3  . LYS A 1 172 ? -51.430 14.932 1.532   1.00 58.59 ? 138 LYS A HZ3  1 
ATOM   2156 N N    . ALA A 1 173 ? -47.270 19.792 -0.246  1.00 18.19 ? 139 ALA A N    1 
ATOM   2157 C CA   . ALA A 1 173 ? -47.782 21.003 0.384   1.00 18.24 ? 139 ALA A CA   1 
ATOM   2158 C C    . ALA A 1 173 ? -48.113 22.082 -0.638  1.00 17.96 ? 139 ALA A C    1 
ATOM   2159 O O    . ALA A 1 173 ? -49.050 22.862 -0.433  1.00 20.07 ? 139 ALA A O    1 
ATOM   2160 C CB   . ALA A 1 173 ? -46.763 21.541 1.389   1.00 17.27 ? 139 ALA A CB   1 
ATOM   2161 H H    . ALA A 1 173 ? -46.440 19.632 -0.089  1.00 21.85 ? 139 ALA A H    1 
ATOM   2162 H HA   . ALA A 1 173 ? -48.597 20.779 0.860   1.00 21.92 ? 139 ALA A HA   1 
ATOM   2163 H HB1  . ALA A 1 173 ? -47.141 22.311 1.842   1.00 20.75 ? 139 ALA A HB1  1 
ATOM   2164 H HB2  . ALA A 1 173 ? -46.558 20.846 2.034   1.00 20.75 ? 139 ALA A HB2  1 
ATOM   2165 H HB3  . ALA A 1 173 ? -45.957 21.799 0.914   1.00 20.75 ? 139 ALA A HB3  1 
ATOM   2166 N N    . VAL A 1 174 ? -47.370 22.139 -1.737  1.00 15.99 ? 140 VAL A N    1 
ATOM   2167 C CA   . VAL A 1 174 ? -47.427 23.264 -2.664  1.00 14.93 ? 140 VAL A CA   1 
ATOM   2168 C C    . VAL A 1 174 ? -48.213 22.919 -3.921  1.00 18.39 ? 140 VAL A C    1 
ATOM   2169 O O    . VAL A 1 174 ? -49.077 23.685 -4.347  1.00 22.02 ? 140 VAL A O    1 
ATOM   2170 C CB   . VAL A 1 174 ? -45.995 23.736 -3.003  1.00 14.07 ? 140 VAL A CB   1 
ATOM   2171 C CG1  . VAL A 1 174 ? -46.012 24.773 -4.115  1.00 17.59 ? 140 VAL A CG1  1 
ATOM   2172 C CG2  . VAL A 1 174 ? -45.318 24.293 -1.759  1.00 13.37 ? 140 VAL A CG2  1 
ATOM   2173 H H    . VAL A 1 174 ? -46.814 21.527 -1.972  1.00 19.22 ? 140 VAL A H    1 
ATOM   2174 H HA   . VAL A 1 174 ? -47.891 23.997 -2.231  1.00 17.94 ? 140 VAL A HA   1 
ATOM   2175 H HB   . VAL A 1 174 ? -45.482 22.975 -3.318  1.00 16.92 ? 140 VAL A HB   1 
ATOM   2176 H HG11 . VAL A 1 174 ? -45.129 25.167 -4.192  1.00 21.13 ? 140 VAL A HG11 1 
ATOM   2177 H HG12 . VAL A 1 174 ? -46.254 24.339 -4.947  1.00 21.13 ? 140 VAL A HG12 1 
ATOM   2178 H HG13 . VAL A 1 174 ? -46.663 25.458 -3.897  1.00 21.13 ? 140 VAL A HG13 1 
ATOM   2179 H HG21 . VAL A 1 174 ? -44.414 24.562 -1.984  1.00 16.07 ? 140 VAL A HG21 1 
ATOM   2180 H HG22 . VAL A 1 174 ? -45.821 25.059 -1.442  1.00 16.07 ? 140 VAL A HG22 1 
ATOM   2181 H HG23 . VAL A 1 174 ? -45.298 23.605 -1.075  1.00 16.07 ? 140 VAL A HG23 1 
ATOM   2182 N N    . VAL A 1 175 ? -47.929 21.768 -4.533  1.00 18.65 ? 141 VAL A N    1 
ATOM   2183 C CA   . VAL A 1 175 ? -48.643 21.381 -5.747  1.00 17.65 ? 141 VAL A CA   1 
ATOM   2184 C C    . VAL A 1 175 ? -49.989 20.761 -5.404  1.00 21.69 ? 141 VAL A C    1 
ATOM   2185 O O    . VAL A 1 175 ? -51.007 21.074 -6.030  1.00 20.45 ? 141 VAL A O    1 
ATOM   2186 C CB   . VAL A 1 175 ? -47.784 20.422 -6.590  1.00 22.68 ? 141 VAL A CB   1 
ATOM   2187 C CG1  . VAL A 1 175 ? -48.607 19.834 -7.734  1.00 24.94 ? 141 VAL A CG1  1 
ATOM   2188 C CG2  . VAL A 1 175 ? -46.570 21.142 -7.126  1.00 21.26 ? 141 VAL A CG2  1 
ATOM   2189 H H    . VAL A 1 175 ? -47.336 21.203 -4.270  1.00 22.40 ? 141 VAL A H    1 
ATOM   2190 H HA   . VAL A 1 175 ? -48.805 22.180 -6.272  1.00 21.21 ? 141 VAL A HA   1 
ATOM   2191 H HB   . VAL A 1 175 ? -47.483 19.691 -6.028  1.00 27.24 ? 141 VAL A HB   1 
ATOM   2192 H HG11 . VAL A 1 175 ? -48.006 19.433 -8.381  1.00 29.96 ? 141 VAL A HG11 1 
ATOM   2193 H HG12 . VAL A 1 175 ? -49.207 19.161 -7.378  1.00 29.96 ? 141 VAL A HG12 1 
ATOM   2194 H HG13 . VAL A 1 175 ? -49.118 20.544 -8.153  1.00 29.96 ? 141 VAL A HG13 1 
ATOM   2195 H HG21 . VAL A 1 175 ? -46.037 20.519 -7.645  1.00 25.54 ? 141 VAL A HG21 1 
ATOM   2196 H HG22 . VAL A 1 175 ? -46.862 21.876 -7.690  1.00 25.54 ? 141 VAL A HG22 1 
ATOM   2197 H HG23 . VAL A 1 175 ? -46.050 21.483 -6.382  1.00 25.54 ? 141 VAL A HG23 1 
ATOM   2198 N N    . ASP A 1 176 ? -50.016 19.868 -4.415  1.00 17.44 ? 142 ASP A N    1 
ATOM   2199 C CA   . ASP A 1 176 ? -51.235 19.200 -3.980  1.00 21.27 ? 142 ASP A CA   1 
ATOM   2200 C C    . ASP A 1 176 ? -51.726 19.754 -2.647  1.00 19.82 ? 142 ASP A C    1 
ATOM   2201 O O    . ASP A 1 176 ? -52.292 19.025 -1.830  1.00 17.27 ? 142 ASP A O    1 
ATOM   2202 C CB   . ASP A 1 176 ? -51.005 17.693 -3.893  1.00 23.24 ? 142 ASP A CB   1 
ATOM   2203 C CG   . ASP A 1 176 ? -50.485 17.111 -5.193  1.00 24.91 ? 142 ASP A CG   1 
ATOM   2204 O OD1  . ASP A 1 176 ? -51.075 17.409 -6.252  1.00 27.45 ? 142 ASP A OD1  1 
ATOM   2205 O OD2  . ASP A 1 176 ? -49.486 16.363 -5.160  1.00 30.74 ? 142 ASP A OD2  1 
ATOM   2206 H H    . ASP A 1 176 ? -49.320 19.629 -3.970  1.00 20.96 ? 142 ASP A H    1 
ATOM   2207 H HA   . ASP A 1 176 ? -51.934 19.354 -4.635  1.00 25.55 ? 142 ASP A HA   1 
ATOM   2208 H HB2  . ASP A 1 176 ? -50.351 17.511 -3.199  1.00 27.91 ? 142 ASP A HB2  1 
ATOM   2209 H HB3  . ASP A 1 176 ? -51.844 17.255 -3.681  1.00 27.91 ? 142 ASP A HB3  1 
ATOM   2210 N N    . GLY A 1 177 ? -51.507 21.048 -2.420  1.00 17.42 ? 143 GLY A N    1 
ATOM   2211 C CA   . GLY A 1 177 ? -51.935 21.719 -1.213  1.00 16.65 ? 143 GLY A CA   1 
ATOM   2212 C C    . GLY A 1 177 ? -52.140 23.191 -1.499  1.00 17.40 ? 143 GLY A C    1 
ATOM   2213 O O    . GLY A 1 177 ? -51.967 23.655 -2.628  1.00 11.98 ? 143 GLY A O    1 
ATOM   2214 H H    . GLY A 1 177 ? -51.100 21.567 -2.971  1.00 20.93 ? 143 GLY A H    1 
ATOM   2215 H HA2  . GLY A 1 177 ? -52.770 21.338 -0.899  1.00 20.01 ? 143 GLY A HA2  1 
ATOM   2216 H HA3  . GLY A 1 177 ? -51.262 21.621 -0.522  1.00 20.01 ? 143 GLY A HA3  1 
ATOM   2217 N N    . HIS A 1 178 ? -52.501 23.930 -0.457  1.00 15.01 ? 144 HIS A N    1 
ATOM   2218 C CA   . HIS A 1 178 ? -52.886 25.326 -0.607  1.00 18.73 ? 144 HIS A CA   1 
ATOM   2219 C C    . HIS A 1 178 ? -51.719 26.293 -0.458  1.00 16.63 ? 144 HIS A C    1 
ATOM   2220 O O    . HIS A 1 178 ? -51.926 27.506 -0.561  1.00 16.54 ? 144 HIS A O    1 
ATOM   2221 C CB   . HIS A 1 178 ? -53.977 25.674 0.405   1.00 23.59 ? 144 HIS A CB   1 
ATOM   2222 C CG   . HIS A 1 178 ? -55.334 25.189 0.005   1.00 22.26 ? 144 HIS A CG   1 
ATOM   2223 N ND1  . HIS A 1 178 ? -55.819 23.952 0.369   1.00 25.42 ? 144 HIS A ND1  1 
ATOM   2224 C CD2  . HIS A 1 178 ? -56.301 25.767 -0.745  1.00 21.63 ? 144 HIS A CD2  1 
ATOM   2225 C CE1  . HIS A 1 178 ? -57.031 23.792 -0.131  1.00 24.16 ? 144 HIS A CE1  1 
ATOM   2226 N NE2  . HIS A 1 178 ? -57.348 24.880 -0.809  1.00 32.40 ? 144 HIS A NE2  1 
ATOM   2227 H H    . HIS A 1 178 ? -52.532 23.643 0.353   1.00 18.04 ? 144 HIS A H    1 
ATOM   2228 H HA   . HIS A 1 178 ? -53.249 25.451 -1.498  1.00 22.50 ? 144 HIS A HA   1 
ATOM   2229 H HB2  . HIS A 1 178 ? -53.755 25.267 1.257   1.00 28.34 ? 144 HIS A HB2  1 
ATOM   2230 H HB3  . HIS A 1 178 ? -54.022 26.638 0.499   1.00 28.34 ? 144 HIS A HB3  1 
ATOM   2231 H HD2  . HIS A 1 178 ? -56.264 26.607 -1.142  1.00 25.98 ? 144 HIS A HD2  1 
ATOM   2232 H HE1  . HIS A 1 178 ? -57.570 23.042 -0.023  1.00 29.01 ? 144 HIS A HE1  1 
ATOM   2233 H HE2  . HIS A 1 178 ? -58.090 25.012 -1.224  1.00 38.91 ? 144 HIS A HE2  1 
ATOM   2234 N N    . ALA A 1 179 ? -50.507 25.799 -0.232  1.00 14.28 ? 145 ALA A N    1 
ATOM   2235 C CA   . ALA A 1 179 ? -49.356 26.685 -0.161  1.00 12.26 ? 145 ALA A CA   1 
ATOM   2236 C C    . ALA A 1 179 ? -48.964 27.158 -1.556  1.00 15.45 ? 145 ALA A C    1 
ATOM   2237 O O    . ALA A 1 179 ? -49.126 26.443 -2.549  1.00 19.31 ? 145 ALA A O    1 
ATOM   2238 C CB   . ALA A 1 179 ? -48.175 25.981 0.506   1.00 16.12 ? 145 ALA A CB   1 
ATOM   2239 H H    . ALA A 1 179 ? -50.328 24.966 -0.117  1.00 17.16 ? 145 ALA A H    1 
ATOM   2240 H HA   . ALA A 1 179 ? -49.579 27.463 0.375   1.00 14.74 ? 145 ALA A HA   1 
ATOM   2241 H HB1  . ALA A 1 179 ? -47.421 26.591 0.538   1.00 19.37 ? 145 ALA A HB1  1 
ATOM   2242 H HB2  . ALA A 1 179 ? -48.428 25.722 1.406   1.00 19.37 ? 145 ALA A HB2  1 
ATOM   2243 H HB3  . ALA A 1 179 ? -47.943 25.195 -0.012  1.00 19.37 ? 145 ALA A HB3  1 
ATOM   2244 N N    . ASP A 1 180 ? -48.445 28.382 -1.622  1.00 18.67 ? 146 ASP A N    1 
ATOM   2245 C CA   . ASP A 1 180 ? -47.978 28.968 -2.870  1.00 15.04 ? 146 ASP A CA   1 
ATOM   2246 C C    . ASP A 1 180 ? -46.485 28.782 -3.092  1.00 18.50 ? 146 ASP A C    1 
ATOM   2247 O O    . ASP A 1 180 ? -45.988 29.114 -4.173  1.00 15.93 ? 146 ASP A O    1 
ATOM   2248 C CB   . ASP A 1 180 ? -48.315 30.462 -2.902  1.00 19.84 ? 146 ASP A CB   1 
ATOM   2249 C CG   . ASP A 1 180 ? -49.793 30.723 -2.703  1.00 15.58 ? 146 ASP A CG   1 
ATOM   2250 O OD1  . ASP A 1 180 ? -50.588 30.314 -3.572  1.00 18.00 ? 146 ASP A OD1  1 
ATOM   2251 O OD2  . ASP A 1 180 ? -50.159 31.313 -1.667  1.00 18.78 ? 146 ASP A OD2  1 
ATOM   2252 H H    . ASP A 1 180 ? -48.352 28.902 -0.943  1.00 22.43 ? 146 ASP A H    1 
ATOM   2253 H HA   . ASP A 1 180 ? -48.440 28.541 -3.609  1.00 18.07 ? 146 ASP A HA   1 
ATOM   2254 H HB2  . ASP A 1 180 ? -47.831 30.912 -2.192  1.00 23.84 ? 146 ASP A HB2  1 
ATOM   2255 H HB3  . ASP A 1 180 ? -48.057 30.828 -3.762  1.00 23.84 ? 146 ASP A HB3  1 
ATOM   2256 N N    . GLY A 1 181 ? -45.764 28.262 -2.108  1.00 14.66 ? 147 GLY A N    1 
ATOM   2257 C CA   . GLY A 1 181 ? -44.335 28.069 -2.257  1.00 17.15 ? 147 GLY A CA   1 
ATOM   2258 C C    . GLY A 1 181 ? -43.768 27.409 -1.022  1.00 13.36 ? 147 GLY A C    1 
ATOM   2259 O O    . GLY A 1 181 ? -44.493 27.055 -0.085  1.00 15.99 ? 147 GLY A O    1 
ATOM   2260 H H    . GLY A 1 181 ? -46.080 28.014 -1.348  1.00 17.62 ? 147 GLY A H    1 
ATOM   2261 H HA2  . GLY A 1 181 ? -44.156 27.505 -3.025  1.00 20.60 ? 147 GLY A HA2  1 
ATOM   2262 H HA3  . GLY A 1 181 ? -43.897 28.925 -2.385  1.00 20.60 ? 147 GLY A HA3  1 
ATOM   2263 N N    . VAL A 1 182 ? -42.449 27.249 -1.033  1.00 12.57 ? 148 VAL A N    1 
ATOM   2264 C CA   . VAL A 1 182 ? -41.727 26.601 0.053   1.00 17.29 ? 148 VAL A CA   1 
ATOM   2265 C C    . VAL A 1 182 ? -40.622 27.530 0.530   1.00 15.71 ? 148 VAL A C    1 
ATOM   2266 O O    . VAL A 1 182 ? -39.954 28.185 -0.278  1.00 12.92 ? 148 VAL A O    1 
ATOM   2267 C CB   . VAL A 1 182 ? -41.141 25.240 -0.378  1.00 11.83 ? 148 VAL A CB   1 
ATOM   2268 C CG1  . VAL A 1 182 ? -40.177 25.416 -1.540  1.00 18.69 ? 148 VAL A CG1  1 
ATOM   2269 C CG2  . VAL A 1 182 ? -40.446 24.561 0.802   1.00 14.71 ? 148 VAL A CG2  1 
ATOM   2270 H H    . VAL A 1 182 ? -41.940 27.515 -1.673  1.00 15.12 ? 148 VAL A H    1 
ATOM   2271 H HA   . VAL A 1 182 ? -42.339 26.450 0.791   1.00 20.77 ? 148 VAL A HA   1 
ATOM   2272 H HB   . VAL A 1 182 ? -41.865 24.667 -0.674  1.00 14.22 ? 148 VAL A HB   1 
ATOM   2273 H HG11 . VAL A 1 182 ? -39.922 24.541 -1.874  1.00 22.46 ? 148 VAL A HG11 1 
ATOM   2274 H HG12 . VAL A 1 182 ? -40.616 25.922 -2.241  1.00 22.46 ? 148 VAL A HG12 1 
ATOM   2275 H HG13 . VAL A 1 182 ? -39.392 25.893 -1.230  1.00 22.46 ? 148 VAL A HG13 1 
ATOM   2276 H HG21 . VAL A 1 182 ? -40.168 23.671 0.536   1.00 17.68 ? 148 VAL A HG21 1 
ATOM   2277 H HG22 . VAL A 1 182 ? -39.672 25.087 1.058   1.00 17.68 ? 148 VAL A HG22 1 
ATOM   2278 H HG23 . VAL A 1 182 ? -41.067 24.505 1.545   1.00 17.68 ? 148 VAL A HG23 1 
ATOM   2279 N N    . PHE A 1 183 ? -40.437 27.583 1.844   1.00 15.59 ? 149 PHE A N    1 
ATOM   2280 C CA   . PHE A 1 183 ? -39.329 28.298 2.465   1.00 16.29 ? 149 PHE A CA   1 
ATOM   2281 C C    . PHE A 1 183 ? -38.279 27.264 2.858   1.00 14.33 ? 149 PHE A C    1 
ATOM   2282 O O    . PHE A 1 183 ? -38.496 26.471 3.780   1.00 16.46 ? 149 PHE A O    1 
ATOM   2283 C CB   . PHE A 1 183 ? -39.813 29.092 3.675   1.00 12.50 ? 149 PHE A CB   1 
ATOM   2284 C CG   . PHE A 1 183 ? -38.750 29.933 4.316   1.00 14.14 ? 149 PHE A CG   1 
ATOM   2285 C CD1  . PHE A 1 183 ? -37.817 29.372 5.171   1.00 24.64 ? 149 PHE A CD1  1 
ATOM   2286 C CD2  . PHE A 1 183 ? -38.692 31.290 4.070   1.00 26.20 ? 149 PHE A CD2  1 
ATOM   2287 C CE1  . PHE A 1 183 ? -36.841 30.149 5.762   1.00 18.62 ? 149 PHE A CE1  1 
ATOM   2288 C CE2  . PHE A 1 183 ? -37.724 32.068 4.655   1.00 26.33 ? 149 PHE A CE2  1 
ATOM   2289 C CZ   . PHE A 1 183 ? -36.794 31.501 5.503   1.00 25.84 ? 149 PHE A CZ   1 
ATOM   2290 H H    . PHE A 1 183 ? -40.956 27.202 2.414   1.00 18.73 ? 149 PHE A H    1 
ATOM   2291 H HA   . PHE A 1 183 ? -38.935 28.921 1.835   1.00 19.57 ? 149 PHE A HA   1 
ATOM   2292 H HB2  . PHE A 1 183 ? -40.528 29.685 3.393   1.00 15.02 ? 149 PHE A HB2  1 
ATOM   2293 H HB3  . PHE A 1 183 ? -40.141 28.471 4.344   1.00 15.02 ? 149 PHE A HB3  1 
ATOM   2294 H HD1  . PHE A 1 183 ? -37.848 28.459 5.349   1.00 29.59 ? 149 PHE A HD1  1 
ATOM   2295 H HD2  . PHE A 1 183 ? -39.315 31.681 3.502   1.00 31.47 ? 149 PHE A HD2  1 
ATOM   2296 H HE1  . PHE A 1 183 ? -36.217 29.761 6.332   1.00 22.37 ? 149 PHE A HE1  1 
ATOM   2297 H HE2  . PHE A 1 183 ? -37.695 32.981 4.480   1.00 31.62 ? 149 PHE A HE2  1 
ATOM   2298 H HZ   . PHE A 1 183 ? -36.139 32.030 5.898   1.00 31.03 ? 149 PHE A HZ   1 
ATOM   2299 N N    . MET A 1 184 ? -37.153 27.261 2.150   1.00 15.87 ? 150 MET A N    1 
ATOM   2300 C CA   . MET A 1 184 ? -36.055 26.339 2.431   1.00 17.46 ? 150 MET A CA   1 
ATOM   2301 C C    . MET A 1 184 ? -35.081 27.021 3.384   1.00 15.67 ? 150 MET A C    1 
ATOM   2302 O O    . MET A 1 184 ? -34.367 27.950 2.995   1.00 18.05 ? 150 MET A O    1 
ATOM   2303 C CB   . MET A 1 184 ? -35.357 25.913 1.141   1.00 17.39 ? 150 MET A CB   1 
ATOM   2304 C CG   . MET A 1 184 ? -36.306 25.591 -0.000  1.00 15.70 ? 150 MET A CG   1 
ATOM   2305 S SD   . MET A 1 184 ? -35.465 25.164 -1.538  1.00 17.76 ? 150 MET A SD   1 
ATOM   2306 C CE   . MET A 1 184 ? -34.504 23.731 -1.056  1.00 17.47 ? 150 MET A CE   1 
ATOM   2307 H H    . MET A 1 184 ? -36.998 27.792 1.492   1.00 19.07 ? 150 MET A H    1 
ATOM   2308 H HA   . MET A 1 184 ? -36.413 25.541 2.851   1.00 20.98 ? 150 MET A HA   1 
ATOM   2309 H HB2  . MET A 1 184 ? -34.778 26.634 0.849   1.00 20.89 ? 150 MET A HB2  1 
ATOM   2310 H HB3  . MET A 1 184 ? -34.831 25.118 1.320   1.00 20.89 ? 150 MET A HB3  1 
ATOM   2311 H HG2  . MET A 1 184 ? -36.858 24.836 0.255   1.00 18.87 ? 150 MET A HG2  1 
ATOM   2312 H HG3  . MET A 1 184 ? -36.863 26.367 -0.172  1.00 18.87 ? 150 MET A HG3  1 
ATOM   2313 H HE1  . MET A 1 184 ? -34.007 23.411 -1.825  1.00 20.99 ? 150 MET A HE1  1 
ATOM   2314 H HE2  . MET A 1 184 ? -33.891 23.984 -0.348  1.00 20.99 ? 150 MET A HE2  1 
ATOM   2315 H HE3  . MET A 1 184 ? -35.106 23.039 -0.741  1.00 20.99 ? 150 MET A HE3  1 
ATOM   2316 N N    . ASP A 1 185 ? -35.052 26.558 4.630   1.00 14.95 ? 151 ASP A N    1 
ATOM   2317 C CA   . ASP A 1 185 ? -34.235 27.151 5.678   1.00 19.01 ? 151 ASP A CA   1 
ATOM   2318 C C    . ASP A 1 185 ? -32.943 26.368 5.879   1.00 21.49 ? 151 ASP A C    1 
ATOM   2319 O O    . ASP A 1 185 ? -32.800 25.226 5.434   1.00 18.14 ? 151 ASP A O    1 
ATOM   2320 C CB   . ASP A 1 185 ? -35.010 27.199 7.000   1.00 18.09 ? 151 ASP A CB   1 
ATOM   2321 C CG   . ASP A 1 185 ? -34.485 28.261 7.950   1.00 17.60 ? 151 ASP A CG   1 
ATOM   2322 O OD1  . ASP A 1 185 ? -33.629 29.067 7.532   1.00 16.33 ? 151 ASP A OD1  1 
ATOM   2323 O OD2  . ASP A 1 185 ? -34.923 28.283 9.120   1.00 14.28 ? 151 ASP A OD2  1 
ATOM   2324 H H    . ASP A 1 185 ? -35.511 25.882 4.898   1.00 17.97 ? 151 ASP A H    1 
ATOM   2325 H HA   . ASP A 1 185 ? -34.002 28.055 5.415   1.00 22.84 ? 151 ASP A HA   1 
ATOM   2326 H HB2  . ASP A 1 185 ? -35.941 27.398 6.813   1.00 21.73 ? 151 ASP A HB2  1 
ATOM   2327 H HB3  . ASP A 1 185 ? -34.937 26.339 7.441   1.00 21.73 ? 151 ASP A HB3  1 
ATOM   2328 N N    . ALA A 1 186 ? -31.989 27.023 6.544   1.00 18.93 ? 152 ALA A N    1 
ATOM   2329 C CA   . ALA A 1 186 ? -30.820 26.374 7.129   1.00 17.92 ? 152 ALA A CA   1 
ATOM   2330 C C    . ALA A 1 186 ? -29.668 26.199 6.145   1.00 17.88 ? 152 ALA A C    1 
ATOM   2331 O O    . ALA A 1 186 ? -28.739 25.432 6.414   1.00 15.19 ? 152 ALA A O    1 
ATOM   2332 C CB   . ALA A 1 186 ? -31.202 25.010 7.714   1.00 21.77 ? 152 ALA A CB   1 
ATOM   2333 H H    . ALA A 1 186 ? -31.998 27.873 6.675   1.00 22.74 ? 152 ALA A H    1 
ATOM   2334 H HA   . ALA A 1 186 ? -30.498 26.955 7.836   1.00 21.53 ? 152 ALA A HA   1 
ATOM   2335 H HB1  . ALA A 1 186 ? -30.480 24.696 8.280   1.00 26.15 ? 152 ALA A HB1  1 
ATOM   2336 H HB2  . ALA A 1 186 ? -32.014 25.108 8.237   1.00 26.15 ? 152 ALA A HB2  1 
ATOM   2337 H HB3  . ALA A 1 186 ? -31.350 24.385 6.988   1.00 26.15 ? 152 ALA A HB3  1 
ATOM   2338 N N    . PHE A 1 187 ? -29.700 26.904 5.012   1.00 15.34 ? 153 PHE A N    1 
ATOM   2339 C CA   . PHE A 1 187 ? -28.558 26.854 4.104   1.00 21.62 ? 153 PHE A CA   1 
ATOM   2340 C C    . PHE A 1 187 ? -27.278 27.257 4.829   1.00 21.39 ? 153 PHE A C    1 
ATOM   2341 O O    . PHE A 1 187 ? -26.213 26.669 4.606   1.00 16.50 ? 153 PHE A O    1 
ATOM   2342 C CB   . PHE A 1 187 ? -28.784 27.764 2.894   1.00 18.22 ? 153 PHE A CB   1 
ATOM   2343 C CG   . PHE A 1 187 ? -29.847 27.279 1.938   1.00 21.66 ? 153 PHE A CG   1 
ATOM   2344 C CD1  . PHE A 1 187 ? -30.771 26.315 2.310   1.00 15.62 ? 153 PHE A CD1  1 
ATOM   2345 C CD2  . PHE A 1 187 ? -29.916 27.802 0.656   1.00 18.22 ? 153 PHE A CD2  1 
ATOM   2346 C CE1  . PHE A 1 187 ? -31.741 25.887 1.423   1.00 17.72 ? 153 PHE A CE1  1 
ATOM   2347 C CE2  . PHE A 1 187 ? -30.881 27.378 -0.232  1.00 14.45 ? 153 PHE A CE2  1 
ATOM   2348 C CZ   . PHE A 1 187 ? -31.794 26.419 0.150   1.00 19.66 ? 153 PHE A CZ   1 
ATOM   2349 H H    . PHE A 1 187 ? -30.352 27.403 4.754   1.00 18.44 ? 153 PHE A H    1 
ATOM   2350 H HA   . PHE A 1 187 ? -28.464 25.946 3.776   1.00 25.97 ? 153 PHE A HA   1 
ATOM   2351 H HB2  . PHE A 1 187 ? -29.053 28.640 3.212   1.00 21.89 ? 153 PHE A HB2  1 
ATOM   2352 H HB3  . PHE A 1 187 ? -27.953 27.832 2.398   1.00 21.89 ? 153 PHE A HB3  1 
ATOM   2353 H HD1  . PHE A 1 187 ? -30.739 25.953 3.165   1.00 18.77 ? 153 PHE A HD1  1 
ATOM   2354 H HD2  . PHE A 1 187 ? -29.302 28.449 0.391   1.00 21.90 ? 153 PHE A HD2  1 
ATOM   2355 H HE1  . PHE A 1 187 ? -32.357 25.242 1.684   1.00 21.29 ? 153 PHE A HE1  1 
ATOM   2356 H HE2  . PHE A 1 187 ? -30.916 27.739 -1.089  1.00 17.37 ? 153 PHE A HE2  1 
ATOM   2357 H HZ   . PHE A 1 187 ? -32.445 26.130 -0.448  1.00 23.62 ? 153 PHE A HZ   1 
ATOM   2358 N N    . ILE A 1 188 ? -27.363 28.248 5.703   1.00 20.39 ? 154 ILE A N    1 
ATOM   2359 C CA   . ILE A 1 188 ? -26.188 28.736 6.411   1.00 20.31 ? 154 ILE A CA   1 
ATOM   2360 C C    . ILE A 1 188 ? -25.563 27.611 7.265   1.00 20.99 ? 154 ILE A C    1 
ATOM   2361 O O    . ILE A 1 188 ? -24.367 27.509 7.373   1.00 18.43 ? 154 ILE A O    1 
ATOM   2362 C CB   . ILE A 1 188 ? -26.523 30.006 7.246   1.00 22.95 ? 154 ILE A CB   1 
ATOM   2363 C CG1  . ILE A 1 188 ? -26.984 31.149 6.350   1.00 27.37 ? 154 ILE A CG1  1 
ATOM   2364 C CG2  . ILE A 1 188 ? -25.324 30.462 8.049   1.00 23.64 ? 154 ILE A CG2  1 
ATOM   2365 C CD1  . ILE A 1 188 ? -25.919 31.630 5.400   1.00 32.80 ? 154 ILE A CD1  1 
ATOM   2366 H H    . ILE A 1 188 ? -28.088 28.659 5.918   1.00 24.49 ? 154 ILE A H    1 
ATOM   2367 H HA   . ILE A 1 188 ? -25.516 28.989 5.746   1.00 24.40 ? 154 ILE A HA   1 
ATOM   2368 H HB   . ILE A 1 188 ? -27.240 29.784 7.857   1.00 27.57 ? 154 ILE A HB   1 
ATOM   2369 H HG12 . ILE A 1 188 ? -27.743 30.854 5.823   1.00 32.87 ? 154 ILE A HG12 1 
ATOM   2370 H HG13 . ILE A 1 188 ? -27.241 31.898 6.910   1.00 32.87 ? 154 ILE A HG13 1 
ATOM   2371 H HG21 . ILE A 1 188 ? -25.436 31.390 8.273   1.00 28.40 ? 154 ILE A HG21 1 
ATOM   2372 H HG22 . ILE A 1 188 ? -25.259 29.932 8.846   1.00 28.40 ? 154 ILE A HG22 1 
ATOM   2373 H HG23 . ILE A 1 188 ? -24.538 30.346 7.512   1.00 28.40 ? 154 ILE A HG23 1 
ATOM   2374 N N    . GLN A 1 189 ? -26.406 26.756 7.825   1.00 18.46 ? 155 GLN A N    1 
ATOM   2375 C CA   . GLN A 1 189 ? -25.891 25.669 8.646   1.00 18.67 ? 155 GLN A CA   1 
ATOM   2376 C C    . GLN A 1 189 ? -25.288 24.556 7.800   1.00 20.42 ? 155 GLN A C    1 
ATOM   2377 O O    . GLN A 1 189 ? -24.367 23.869 8.255   1.00 17.22 ? 155 GLN A O    1 
ATOM   2378 C CB   . GLN A 1 189 ? -27.006 25.117 9.533   1.00 19.98 ? 155 GLN A CB   1 
ATOM   2379 C CG   . GLN A 1 189 ? -27.419 26.069 10.643  1.00 23.70 ? 155 GLN A CG   1 
ATOM   2380 C CD   . GLN A 1 189 ? -28.527 25.509 11.508  1.00 29.71 ? 155 GLN A CD   1 
ATOM   2381 O OE1  . GLN A 1 189 ? -28.324 24.549 12.252  1.00 35.73 ? 155 GLN A OE1  1 
ATOM   2382 N NE2  . GLN A 1 189 ? -29.710 26.105 11.415  1.00 27.46 ? 155 GLN A NE2  1 
ATOM   2383 H H    . GLN A 1 189 ? -27.262 26.774 7.747   1.00 22.18 ? 155 GLN A H    1 
ATOM   2384 H HA   . GLN A 1 189 ? -25.192 26.012 9.224   1.00 22.43 ? 155 GLN A HA   1 
ATOM   2385 H HB2  . GLN A 1 189 ? -27.786 24.943 8.984   1.00 24.00 ? 155 GLN A HB2  1 
ATOM   2386 H HB3  . GLN A 1 189 ? -26.699 24.294 9.945   1.00 24.00 ? 155 GLN A HB3  1 
ATOM   2387 H HG2  . GLN A 1 189 ? -26.653 26.244 11.211  1.00 28.47 ? 155 GLN A HG2  1 
ATOM   2388 H HG3  . GLN A 1 189 ? -27.736 26.896 10.248  1.00 28.47 ? 155 GLN A HG3  1 
ATOM   2389 H HE21 . GLN A 1 189 ? -29.814 26.773 10.883  1.00 32.98 ? 155 GLN A HE21 1 
ATOM   2390 H HE22 . GLN A 1 189 ? -30.372 25.824 11.887  1.00 32.98 ? 155 GLN A HE22 1 
ATOM   2391 N N    . VAL A 1 190 ? -25.784 24.366 6.577   1.00 17.89 ? 156 VAL A N    1 
ATOM   2392 C CA   . VAL A 1 190 ? -25.214 23.353 5.694   1.00 22.25 ? 156 VAL A CA   1 
ATOM   2393 C C    . VAL A 1 190 ? -23.780 23.712 5.327   1.00 23.00 ? 156 VAL A C    1 
ATOM   2394 O O    . VAL A 1 190 ? -22.874 22.872 5.390   1.00 20.73 ? 156 VAL A O    1 
ATOM   2395 C CB   . VAL A 1 190 ? -26.084 23.191 4.435   1.00 17.01 ? 156 VAL A CB   1 
ATOM   2396 C CG1  . VAL A 1 190 ? -25.421 22.230 3.456   1.00 18.43 ? 156 VAL A CG1  1 
ATOM   2397 C CG2  . VAL A 1 190 ? -27.479 22.714 4.804   1.00 16.73 ? 156 VAL A CG2  1 
ATOM   2398 H H    . VAL A 1 190 ? -26.442 24.805 6.240   1.00 21.50 ? 156 VAL A H    1 
ATOM   2399 H HA   . VAL A 1 190 ? -25.203 22.507 6.168   1.00 26.73 ? 156 VAL A HA   1 
ATOM   2400 H HB   . VAL A 1 190 ? -26.173 24.053 3.999   1.00 20.43 ? 156 VAL A HB   1 
ATOM   2401 H HG11 . VAL A 1 190 ? -26.063 21.983 2.772   1.00 22.15 ? 156 VAL A HG11 1 
ATOM   2402 H HG12 . VAL A 1 190 ? -24.658 22.670 3.050   1.00 22.15 ? 156 VAL A HG12 1 
ATOM   2403 H HG13 . VAL A 1 190 ? -25.130 21.440 3.937   1.00 22.15 ? 156 VAL A HG13 1 
ATOM   2404 H HG21 . VAL A 1 190 ? -27.979 22.542 3.991   1.00 20.10 ? 156 VAL A HG21 1 
ATOM   2405 H HG22 . VAL A 1 190 ? -27.406 21.899 5.326   1.00 20.10 ? 156 VAL A HG22 1 
ATOM   2406 H HG23 . VAL A 1 190 ? -27.921 23.402 5.325   1.00 20.10 ? 156 VAL A HG23 1 
ATOM   2407 N N    . ILE A 1 191 ? -23.555 24.968 4.933   1.00 19.62 ? 157 ILE A N    1 
ATOM   2408 C CA   . ILE A 1 191 ? -22.259 25.372 4.400   1.00 25.44 ? 157 ILE A CA   1 
ATOM   2409 C C    . ILE A 1 191 ? -21.223 25.612 5.490   1.00 23.84 ? 157 ILE A C    1 
ATOM   2410 O O    . ILE A 1 191 ? -20.026 25.671 5.185   1.00 24.72 ? 157 ILE A O    1 
ATOM   2411 C CB   . ILE A 1 191 ? -22.416 26.637 3.535   1.00 27.84 ? 157 ILE A CB   1 
ATOM   2412 C CG1  . ILE A 1 191 ? -22.756 27.841 4.421   1.00 32.77 ? 157 ILE A CG1  1 
ATOM   2413 C CG2  . ILE A 1 191 ? -23.480 26.412 2.458   1.00 34.34 ? 157 ILE A CG2  1 
ATOM   2414 H H    . ILE A 1 191 ? -24.135 25.601 4.966   1.00 23.57 ? 157 ILE A H    1 
ATOM   2415 H HA   . ILE A 1 191 ? -21.925 24.651 3.844   1.00 30.55 ? 157 ILE A HA   1 
ATOM   2416 H HB   . ILE A 1 191 ? -21.575 26.822 3.089   1.00 33.44 ? 157 ILE A HB   1 
ATOM   2417 H HG12 . ILE A 1 191 ? -23.456 27.579 5.040   1.00 39.35 ? 157 ILE A HG12 1 
ATOM   2418 H HG13 . ILE A 1 191 ? -21.959 28.098 4.910   1.00 39.35 ? 157 ILE A HG13 1 
ATOM   2419 H HG21 . ILE A 1 191 ? -23.537 27.204 1.900   1.00 41.23 ? 157 ILE A HG21 1 
ATOM   2420 H HG22 . ILE A 1 191 ? -23.228 25.646 1.919   1.00 41.23 ? 157 ILE A HG22 1 
ATOM   2421 H HG23 . ILE A 1 191 ? -24.334 26.248 2.887   1.00 41.23 ? 157 ILE A HG23 1 
ATOM   2422 N N    . ASN A 1 192 ? -21.644 25.754 6.747   1.00 26.30 ? 158 ASN A N    1 
ATOM   2423 C CA   . ASN A 1 192 ? -20.726 25.973 7.858   1.00 20.83 ? 158 ASN A CA   1 
ATOM   2424 C C    . ASN A 1 192 ? -19.521 25.049 7.759   1.00 27.16 ? 158 ASN A C    1 
ATOM   2425 O O    . ASN A 1 192 ? -19.656 23.823 7.816   1.00 25.88 ? 158 ASN A O    1 
ATOM   2426 C CB   . ASN A 1 192 ? -21.454 25.748 9.185   1.00 21.52 ? 158 ASN A CB   1 
ATOM   2427 C CG   . ASN A 1 192 ? -20.501 25.646 10.365  1.00 29.61 ? 158 ASN A CG   1 
ATOM   2428 O OD1  . ASN A 1 192 ? -19.433 26.259 10.372  1.00 27.28 ? 158 ASN A OD1  1 
ATOM   2429 N ND2  . ASN A 1 192 ? -20.886 24.867 11.370  1.00 33.43 ? 158 ASN A ND2  1 
ATOM   2430 H H    . ASN A 1 192 ? -22.471 25.727 6.983   1.00 31.59 ? 158 ASN A H    1 
ATOM   2431 H HA   . ASN A 1 192 ? -20.413 26.891 7.836   1.00 25.02 ? 158 ASN A HA   1 
ATOM   2432 H HB2  . ASN A 1 192 ? -22.054 26.492 9.347   1.00 25.85 ? 158 ASN A HB2  1 
ATOM   2433 H HB3  . ASN A 1 192 ? -21.957 24.920 9.133   1.00 25.85 ? 158 ASN A HB3  1 
ATOM   2434 H HD21 . ASN A 1 192 ? -20.383 24.777 12.061  1.00 40.14 ? 158 ASN A HD21 1 
ATOM   2435 H HD22 . ASN A 1 192 ? -21.639 24.454 11.329  1.00 40.14 ? 158 ASN A HD22 1 
ATOM   2436 N N    . LYS A 1 193 ? -18.336 25.643 7.608   1.00 28.79 ? 159 LYS A N    1 
ATOM   2437 C CA   . LYS A 1 193 ? -17.132 24.851 7.395   1.00 27.45 ? 159 LYS A CA   1 
ATOM   2438 C C    . LYS A 1 193 ? -16.771 24.007 8.608   1.00 27.32 ? 159 LYS A C    1 
ATOM   2439 O O    . LYS A 1 193 ? -16.006 23.045 8.469   1.00 30.31 ? 159 LYS A O    1 
ATOM   2440 C CB   . LYS A 1 193 ? -15.963 25.762 7.026   1.00 30.73 ? 159 LYS A CB   1 
ATOM   2441 C CG   . LYS A 1 193 ? -16.241 26.642 5.815   1.00 35.86 ? 159 LYS A CG   1 
ATOM   2442 C CD   . LYS A 1 193 ? -15.525 26.156 4.564   1.00 35.64 ? 159 LYS A CD   1 
ATOM   2443 C CE   . LYS A 1 193 ? -15.022 27.321 3.730   1.00 45.13 ? 159 LYS A CE   1 
ATOM   2444 N NZ   . LYS A 1 193 ? -13.983 28.114 4.445   1.00 48.88 ? 159 LYS A NZ   1 
ATOM   2445 H H    . LYS A 1 193 ? -18.207 26.493 7.625   1.00 34.58 ? 159 LYS A H    1 
ATOM   2446 H HA   . LYS A 1 193 ? -17.286 24.248 6.651   1.00 32.97 ? 159 LYS A HA   1 
ATOM   2447 H HB2  . LYS A 1 193 ? -15.770 26.343 7.778   1.00 36.90 ? 159 LYS A HB2  1 
ATOM   2448 H HB3  . LYS A 1 193 ? -15.190 25.213 6.823   1.00 36.90 ? 159 LYS A HB3  1 
ATOM   2449 H HG2  . LYS A 1 193 ? -17.194 26.642 5.635   1.00 43.06 ? 159 LYS A HG2  1 
ATOM   2450 H HG3  . LYS A 1 193 ? -15.939 27.545 6.003   1.00 43.06 ? 159 LYS A HG3  1 
ATOM   2451 H HD2  . LYS A 1 193 ? -14.763 25.612 4.820   1.00 42.79 ? 159 LYS A HD2  1 
ATOM   2452 H HD3  . LYS A 1 193 ? -16.138 25.634 4.023   1.00 42.79 ? 159 LYS A HD3  1 
ATOM   2453 H HE2  . LYS A 1 193 ? -14.632 26.982 2.909   1.00 54.18 ? 159 LYS A HE2  1 
ATOM   2454 H HE3  . LYS A 1 193 ? -15.765 27.911 3.525   1.00 54.18 ? 159 LYS A HE3  1 
ATOM   2455 H HZ1  . LYS A 1 193 ? -13.668 28.754 3.913   1.00 58.69 ? 159 LYS A HZ1  1 
ATOM   2456 H HZ2  . LYS A 1 193 ? -14.334 28.490 5.172   1.00 58.69 ? 159 LYS A HZ2  1 
ATOM   2457 H HZ3  . LYS A 1 193 ? -13.311 27.584 4.689   1.00 58.69 ? 159 LYS A HZ3  1 
ATOM   2458 N N    . GLY A 1 194 ? -17.291 24.339 9.788   1.00 29.04 ? 160 GLY A N    1 
ATOM   2459 C CA   . GLY A 1 194 ? -17.138 23.450 10.922  1.00 25.76 ? 160 GLY A CA   1 
ATOM   2460 C C    . GLY A 1 194 ? -17.632 22.041 10.654  1.00 28.57 ? 160 GLY A C    1 
ATOM   2461 O O    . GLY A 1 194 ? -17.195 21.101 11.325  1.00 28.70 ? 160 GLY A O    1 
ATOM   2462 H H    . GLY A 1 194 ? -17.727 25.062 9.949   1.00 34.88 ? 160 GLY A H    1 
ATOM   2463 H HA2  . GLY A 1 194 ? -16.199 23.400 11.161  1.00 30.94 ? 160 GLY A HA2  1 
ATOM   2464 H HA3  . GLY A 1 194 ? -17.637 23.807 11.674  1.00 30.94 ? 160 GLY A HA3  1 
ATOM   2465 N N    . ASN A 1 195 ? -18.529 21.872 9.676   1.00 29.43 ? 161 ASN A N    1 
ATOM   2466 C CA   . ASN A 1 195 ? -19.031 20.543 9.338   1.00 26.06 ? 161 ASN A CA   1 
ATOM   2467 C C    . ASN A 1 195 ? -17.940 19.655 8.754   1.00 24.87 ? 161 ASN A C    1 
ATOM   2468 O O    . ASN A 1 195 ? -18.026 18.426 8.857   1.00 23.48 ? 161 ASN A O    1 
ATOM   2469 C CB   . ASN A 1 195 ? -20.192 20.667 8.351   1.00 23.80 ? 161 ASN A CB   1 
ATOM   2470 C CG   . ASN A 1 195 ? -21.427 21.288 8.978   1.00 23.56 ? 161 ASN A CG   1 
ATOM   2471 O OD1  . ASN A 1 195 ? -21.692 21.110 10.168  1.00 22.10 ? 161 ASN A OD1  1 
ATOM   2472 N ND2  . ASN A 1 195 ? -22.187 22.025 8.178   1.00 22.02 ? 161 ASN A ND2  1 
ATOM   2473 H H    . ASN A 1 195 ? -18.859 22.507 9.199   1.00 35.35 ? 161 ASN A H    1 
ATOM   2474 H HA   . ASN A 1 195 ? -19.358 20.119 10.147  1.00 31.30 ? 161 ASN A HA   1 
ATOM   2475 H HB2  . ASN A 1 195 ? -19.919 21.227 7.609   1.00 28.59 ? 161 ASN A HB2  1 
ATOM   2476 H HB3  . ASN A 1 195 ? -20.431 19.783 8.030   1.00 28.59 ? 161 ASN A HB3  1 
ATOM   2477 H HD21 . ASN A 1 195 ? -22.898 22.399 8.485   1.00 26.45 ? 161 ASN A HD21 1 
ATOM   2478 H HD22 . ASN A 1 195 ? -21.969 22.129 7.353   1.00 26.45 ? 161 ASN A HD22 1 
ATOM   2479 N N    . ILE A 1 196 ? -16.916 20.249 8.134   1.00 26.21 ? 162 ILE A N    1 
ATOM   2480 C CA   . ILE A 1 196 ? -15.838 19.450 7.553   1.00 27.83 ? 162 ILE A CA   1 
ATOM   2481 C C    . ILE A 1 196 ? -15.211 18.557 8.616   1.00 25.30 ? 162 ILE A C    1 
ATOM   2482 O O    . ILE A 1 196 ? -14.929 17.377 8.371   1.00 25.76 ? 162 ILE A O    1 
ATOM   2483 C CB   . ILE A 1 196 ? -14.783 20.360 6.895   1.00 24.00 ? 162 ILE A CB   1 
ATOM   2484 C CG1  . ILE A 1 196 ? -15.386 21.139 5.724   1.00 23.10 ? 162 ILE A CG1  1 
ATOM   2485 C CG2  . ILE A 1 196 ? -13.601 19.533 6.409   1.00 31.90 ? 162 ILE A CG2  1 
ATOM   2486 C CD1  . ILE A 1 196 ? -14.651 22.425 5.411   1.00 27.84 ? 162 ILE A CD1  1 
ATOM   2487 H H    . ILE A 1 196 ? -16.825 21.098 8.037   1.00 31.48 ? 162 ILE A H    1 
ATOM   2488 H HA   . ILE A 1 196 ? -16.217 18.884 6.863   1.00 33.42 ? 162 ILE A HA   1 
ATOM   2489 H HB   . ILE A 1 196 ? -14.479 20.994 7.563   1.00 28.83 ? 162 ILE A HB   1 
ATOM   2490 H HG12 . ILE A 1 196 ? -15.359 20.581 4.931   1.00 27.75 ? 162 ILE A HG12 1 
ATOM   2491 H HG13 . ILE A 1 196 ? -16.304 21.366 5.940   1.00 27.75 ? 162 ILE A HG13 1 
ATOM   2492 H HG21 . ILE A 1 196 ? -13.100 20.050 5.759   1.00 38.31 ? 162 ILE A HG21 1 
ATOM   2493 H HG22 . ILE A 1 196 ? -13.034 19.317 7.166   1.00 38.31 ? 162 ILE A HG22 1 
ATOM   2494 H HG23 . ILE A 1 196 ? -13.932 18.719 6.000   1.00 38.31 ? 162 ILE A HG23 1 
ATOM   2495 H HD11 . ILE A 1 196 ? -15.031 22.819 4.610   1.00 33.44 ? 162 ILE A HD11 1 
ATOM   2496 H HD12 . ILE A 1 196 ? -14.749 23.035 6.158   1.00 33.44 ? 162 ILE A HD12 1 
ATOM   2497 H HD13 . ILE A 1 196 ? -13.712 22.225 5.268   1.00 33.44 ? 162 ILE A HD13 1 
ATOM   2498 N N    . GLU A 1 197 ? -14.987 19.103 9.813   1.00 29.66 ? 163 GLU A N    1 
ATOM   2499 C CA   . GLU A 1 197 ? -14.393 18.314 10.888  1.00 28.96 ? 163 GLU A CA   1 
ATOM   2500 C C    . GLU A 1 197 ? -15.252 17.104 11.229  1.00 28.08 ? 163 GLU A C    1 
ATOM   2501 O O    . GLU A 1 197 ? -14.721 16.058 11.618  1.00 29.22 ? 163 GLU A O    1 
ATOM   2502 C CB   . GLU A 1 197 ? -14.185 19.200 12.120  1.00 38.33 ? 163 GLU A CB   1 
ATOM   2503 C CG   . GLU A 1 197 ? -13.801 18.465 13.403  1.00 44.83 ? 163 GLU A CG   1 
ATOM   2504 C CD   . GLU A 1 197 ? -14.015 19.314 14.643  1.00 51.41 ? 163 GLU A CD   1 
ATOM   2505 O OE1  . GLU A 1 197 ? -13.831 20.546 14.561  1.00 53.48 ? 163 GLU A OE1  1 
ATOM   2506 O OE2  . GLU A 1 197 ? -14.368 18.749 15.700  1.00 50.57 ? 163 GLU A OE2  1 
ATOM   2507 H H    . GLU A 1 197 ? -15.167 19.917 10.025  1.00 35.62 ? 163 GLU A H    1 
ATOM   2508 H HA   . GLU A 1 197 ? -13.525 17.987 10.604  1.00 34.79 ? 163 GLU A HA   1 
ATOM   2509 H HB2  . GLU A 1 197 ? -13.474 19.831 11.926  1.00 46.03 ? 163 GLU A HB2  1 
ATOM   2510 H HB3  . GLU A 1 197 ? -15.011 19.676 12.297  1.00 46.03 ? 163 GLU A HB3  1 
ATOM   2511 H HG2  . GLU A 1 197 ? -14.345 17.667 13.486  1.00 53.82 ? 163 GLU A HG2  1 
ATOM   2512 H HG3  . GLU A 1 197 ? -12.862 18.224 13.362  1.00 53.82 ? 163 GLU A HG3  1 
ATOM   2513 N N    . LEU A 1 198 ? -16.572 17.222 11.091  1.00 29.57 ? 164 LEU A N    1 
ATOM   2514 C CA   . LEU A 1 198 ? -17.477 16.131 11.431  1.00 27.71 ? 164 LEU A CA   1 
ATOM   2515 C C    . LEU A 1 198 ? -17.673 15.147 10.287  1.00 25.78 ? 164 LEU A C    1 
ATOM   2516 O O    . LEU A 1 198 ? -17.888 13.954 10.536  1.00 27.44 ? 164 LEU A O    1 
ATOM   2517 C CB   . LEU A 1 198 ? -18.843 16.689 11.840  1.00 26.26 ? 164 LEU A CB   1 
ATOM   2518 C CG   . LEU A 1 198 ? -18.905 17.553 13.101  1.00 30.63 ? 164 LEU A CG   1 
ATOM   2519 C CD1  . LEU A 1 198 ? -20.341 17.991 13.359  1.00 30.73 ? 164 LEU A CD1  1 
ATOM   2520 C CD2  . LEU A 1 198 ? -18.343 16.814 14.306  1.00 32.65 ? 164 LEU A CD2  1 
ATOM   2521 H H    . LEU A 1 198 ? -16.968 17.928 10.801  1.00 35.51 ? 164 LEU A H    1 
ATOM   2522 H HA   . LEU A 1 198 ? -17.104 15.648 12.185  1.00 33.28 ? 164 LEU A HA   1 
ATOM   2523 H HB2  . LEU A 1 198 ? -19.172 17.235 11.109  1.00 31.53 ? 164 LEU A HB2  1 
ATOM   2524 H HB3  . LEU A 1 198 ? -19.439 15.937 11.986  1.00 31.53 ? 164 LEU A HB3  1 
ATOM   2525 H HG   . LEU A 1 198 ? -18.358 18.343 12.968  1.00 36.79 ? 164 LEU A HG   1 
ATOM   2526 H HD11 . LEU A 1 198 ? -20.360 18.568 14.138  1.00 36.90 ? 164 LEU A HD11 1 
ATOM   2527 H HD12 . LEU A 1 198 ? -20.669 18.472 12.583  1.00 36.90 ? 164 LEU A HD12 1 
ATOM   2528 H HD13 . LEU A 1 198 ? -20.888 17.205 13.515  1.00 36.90 ? 164 LEU A HD13 1 
ATOM   2529 H HD21 . LEU A 1 198 ? -18.556 17.313 15.110  1.00 39.21 ? 164 LEU A HD21 1 
ATOM   2530 H HD22 . LEU A 1 198 ? -18.743 15.931 14.349  1.00 39.21 ? 164 LEU A HD22 1 
ATOM   2531 H HD23 . LEU A 1 198 ? -17.381 16.737 14.209  1.00 39.21 ? 164 LEU A HD23 1 
ATOM   2532 N N    . TRP A 1 199 ? -17.605 15.619 9.043   1.00 24.22 ? 165 TRP A N    1 
ATOM   2533 C CA   . TRP A 1 199 ? -17.927 14.809 7.876   1.00 23.27 ? 165 TRP A CA   1 
ATOM   2534 C C    . TRP A 1 199 ? -16.719 14.408 7.049   1.00 25.12 ? 165 TRP A C    1 
ATOM   2535 O O    . TRP A 1 199 ? -16.765 13.375 6.378   1.00 25.24 ? 165 TRP A O    1 
ATOM   2536 C CB   . TRP A 1 199 ? -18.885 15.568 6.951   1.00 24.91 ? 165 TRP A CB   1 
ATOM   2537 C CG   . TRP A 1 199 ? -20.168 15.989 7.577   1.00 19.93 ? 165 TRP A CG   1 
ATOM   2538 C CD1  . TRP A 1 199 ? -20.771 15.444 8.674   1.00 25.62 ? 165 TRP A CD1  1 
ATOM   2539 C CD2  . TRP A 1 199 ? -21.017 17.050 7.136   1.00 17.25 ? 165 TRP A CD2  1 
ATOM   2540 N NE1  . TRP A 1 199 ? -21.947 16.105 8.941   1.00 21.86 ? 165 TRP A NE1  1 
ATOM   2541 C CE2  . TRP A 1 199 ? -22.119 17.096 8.010   1.00 21.30 ? 165 TRP A CE2  1 
ATOM   2542 C CE3  . TRP A 1 199 ? -20.952 17.967 6.082   1.00 18.73 ? 165 TRP A CE3  1 
ATOM   2543 C CZ2  . TRP A 1 199 ? -23.148 18.024 7.865   1.00 19.31 ? 165 TRP A CZ2  1 
ATOM   2544 C CZ3  . TRP A 1 199 ? -21.973 18.888 5.940   1.00 22.49 ? 165 TRP A CZ3  1 
ATOM   2545 C CH2  . TRP A 1 199 ? -23.056 18.910 6.826   1.00 20.36 ? 165 TRP A CH2  1 
ATOM   2546 H H    . TRP A 1 199 ? -17.369 16.422 8.848   1.00 29.09 ? 165 TRP A H    1 
ATOM   2547 H HA   . TRP A 1 199 ? -18.365 14.002 8.187   1.00 27.95 ? 165 TRP A HA   1 
ATOM   2548 H HB2  . TRP A 1 199 ? -18.439 16.371 6.638   1.00 29.92 ? 165 TRP A HB2  1 
ATOM   2549 H HB3  . TRP A 1 199 ? -19.104 14.996 6.199   1.00 29.92 ? 165 TRP A HB3  1 
ATOM   2550 H HD1  . TRP A 1 199 ? -20.436 14.731 9.168   1.00 30.77 ? 165 TRP A HD1  1 
ATOM   2551 H HE1  . TRP A 1 199 ? -22.486 15.925 9.587   1.00 26.26 ? 165 TRP A HE1  1 
ATOM   2552 H HE3  . TRP A 1 199 ? -20.235 17.958 5.489   1.00 22.50 ? 165 TRP A HE3  1 
ATOM   2553 H HZ2  . TRP A 1 199 ? -23.870 18.041 8.452   1.00 23.20 ? 165 TRP A HZ2  1 
ATOM   2554 H HZ3  . TRP A 1 199 ? -21.940 19.504 5.244   1.00 27.01 ? 165 TRP A HZ3  1 
ATOM   2555 H HH2  . TRP A 1 199 ? -23.729 19.540 6.706   1.00 24.46 ? 165 TRP A HH2  1 
ATOM   2556 N N    . GLY A 1 200 ? -15.653 15.196 7.072   1.00 26.99 ? 166 GLY A N    1 
ATOM   2557 C CA   . GLY A 1 200 ? -14.596 15.074 6.093   1.00 27.02 ? 166 GLY A CA   1 
ATOM   2558 C C    . GLY A 1 200 ? -14.883 15.906 4.855   1.00 25.84 ? 166 GLY A C    1 
ATOM   2559 O O    . GLY A 1 200 ? -16.024 16.249 4.545   1.00 24.59 ? 166 GLY A O    1 
ATOM   2560 H H    . GLY A 1 200 ? -15.521 15.815 7.654   1.00 32.42 ? 166 GLY A H    1 
ATOM   2561 H HA2  . GLY A 1 200 ? -13.759 15.374 6.481   1.00 32.45 ? 166 GLY A HA2  1 
ATOM   2562 H HA3  . GLY A 1 200 ? -14.506 14.146 5.828   1.00 32.45 ? 166 GLY A HA3  1 
ATOM   2563 N N    . GLN A 1 201 ? -13.810 16.237 4.134   1.00 21.20 ? 167 GLN A N    1 
ATOM   2564 C CA   . GLN A 1 201 ? -13.938 17.136 2.991   1.00 21.12 ? 167 GLN A CA   1 
ATOM   2565 C C    . GLN A 1 201 ? -14.815 16.528 1.902   1.00 24.77 ? 167 GLN A C    1 
ATOM   2566 O O    . GLN A 1 201 ? -15.696 17.199 1.352   1.00 22.68 ? 167 GLN A O    1 
ATOM   2567 C CB   . GLN A 1 201 ? -12.554 17.477 2.440   1.00 24.00 ? 167 GLN A CB   1 
ATOM   2568 C CG   . GLN A 1 201 ? -12.556 18.618 1.439   1.00 23.34 ? 167 GLN A CG   1 
ATOM   2569 C CD   . GLN A 1 201 ? -12.910 19.949 2.073   1.00 30.63 ? 167 GLN A CD   1 
ATOM   2570 O OE1  . GLN A 1 201 ? -12.256 20.392 3.018   1.00 35.45 ? 167 GLN A OE1  1 
ATOM   2571 N NE2  . GLN A 1 201 ? -13.949 20.595 1.556   1.00 27.82 ? 167 GLN A NE2  1 
ATOM   2572 H H    . GLN A 1 201 ? -13.010 15.958 4.285   1.00 25.46 ? 167 GLN A H    1 
ATOM   2573 H HA   . GLN A 1 201 ? -14.359 17.958 3.289   1.00 25.37 ? 167 GLN A HA   1 
ATOM   2574 H HB2  . GLN A 1 201 ? -11.979 17.732 3.178   1.00 28.83 ? 167 GLN A HB2  1 
ATOM   2575 H HB3  . GLN A 1 201 ? -12.195 16.694 1.994   1.00 28.83 ? 167 GLN A HB3  1 
ATOM   2576 H HG2  . GLN A 1 201 ? -11.673 18.697 1.047   1.00 28.04 ? 167 GLN A HG2  1 
ATOM   2577 H HG3  . GLN A 1 201 ? -13.211 18.432 0.747   1.00 28.04 ? 167 GLN A HG3  1 
ATOM   2578 H HE21 . GLN A 1 201 ? -14.382 20.254 0.896   1.00 33.41 ? 167 GLN A HE21 1 
ATOM   2579 H HE22 . GLN A 1 201 ? -14.189 21.354 1.881   1.00 33.41 ? 167 GLN A HE22 1 
ATOM   2580 N N    . LYS A 1 202 ? -14.586 15.254 1.574   1.00 20.58 ? 168 LYS A N    1 
ATOM   2581 C CA   . LYS A 1 202 ? -15.323 14.627 0.480   1.00 23.10 ? 168 LYS A CA   1 
ATOM   2582 C C    . LYS A 1 202 ? -16.826 14.660 0.739   1.00 20.43 ? 168 LYS A C    1 
ATOM   2583 O O    . LYS A 1 202 ? -17.610 15.050 -0.135  1.00 18.78 ? 168 LYS A O    1 
ATOM   2584 C CB   . LYS A 1 202 ? -14.838 13.190 0.283   1.00 25.24 ? 168 LYS A CB   1 
ATOM   2585 C CG   . LYS A 1 202 ? -15.477 12.468 -0.894  1.00 27.99 ? 168 LYS A CG   1 
ATOM   2586 C CD   . LYS A 1 202 ? -14.990 11.030 -0.993  1.00 28.22 ? 168 LYS A CD   1 
ATOM   2587 C CE   . LYS A 1 202 ? -15.766 10.245 -2.037  1.00 24.76 ? 168 LYS A CE   1 
ATOM   2588 N NZ   . LYS A 1 202 ? -14.919 9.864  -3.199  1.00 44.77 ? 168 LYS A NZ   1 
ATOM   2589 H H    . LYS A 1 202 ? -14.018 14.740 1.964   1.00 24.73 ? 168 LYS A H    1 
ATOM   2590 H HA   . LYS A 1 202 ? -15.150 15.119 -0.338  1.00 27.75 ? 168 LYS A HA   1 
ATOM   2591 H HB2  . LYS A 1 202 ? -13.880 13.204 0.133   1.00 30.31 ? 168 LYS A HB2  1 
ATOM   2592 H HB3  . LYS A 1 202 ? -15.041 12.682 1.084   1.00 30.31 ? 168 LYS A HB3  1 
ATOM   2593 H HG2  . LYS A 1 202 ? -16.441 12.457 -0.780  1.00 33.62 ? 168 LYS A HG2  1 
ATOM   2594 H HG3  . LYS A 1 202 ? -15.246 12.926 -1.717  1.00 33.62 ? 168 LYS A HG3  1 
ATOM   2595 H HD2  . LYS A 1 202 ? -14.053 11.026 -1.243  1.00 33.89 ? 168 LYS A HD2  1 
ATOM   2596 H HD3  . LYS A 1 202 ? -15.106 10.592 -0.135  1.00 33.89 ? 168 LYS A HD3  1 
ATOM   2597 H HE2  . LYS A 1 202 ? -16.110 9.433  -1.634  1.00 29.73 ? 168 LYS A HE2  1 
ATOM   2598 H HE3  . LYS A 1 202 ? -16.500 10.789 -2.363  1.00 29.73 ? 168 LYS A HE3  1 
ATOM   2599 H HZ1  . LYS A 1 202 ? -15.400 9.402  -3.788  1.00 53.75 ? 168 LYS A HZ1  1 
ATOM   2600 H HZ2  . LYS A 1 202 ? -14.600 10.594 -3.596  1.00 53.75 ? 168 LYS A HZ2  1 
ATOM   2601 H HZ3  . LYS A 1 202 ? -14.236 9.362  -2.927  1.00 53.75 ? 168 LYS A HZ3  1 
ATOM   2602 N N    . LYS A 1 203 ? -17.247 14.252 1.938   1.00 21.69 ? 169 LYS A N    1 
ATOM   2603 C CA   . LYS A 1 203 ? -18.672 14.259 2.255   1.00 23.50 ? 169 LYS A CA   1 
ATOM   2604 C C    . LYS A 1 203 ? -19.208 15.683 2.336   1.00 20.44 ? 169 LYS A C    1 
ATOM   2605 O O    . LYS A 1 203 ? -20.331 15.955 1.896   1.00 20.64 ? 169 LYS A O    1 
ATOM   2606 C CB   . LYS A 1 203 ? -18.922 13.512 3.565   1.00 23.67 ? 169 LYS A CB   1 
ATOM   2607 C CG   . LYS A 1 203 ? -20.391 13.400 3.957   1.00 21.42 ? 169 LYS A CG   1 
ATOM   2608 C CD   . LYS A 1 203 ? -21.188 12.575 2.952   1.00 20.12 ? 169 LYS A CD   1 
ATOM   2609 C CE   . LYS A 1 203 ? -22.386 11.905 3.611   1.00 21.05 ? 169 LYS A CE   1 
ATOM   2610 N NZ   . LYS A 1 203 ? -23.121 11.003 2.685   1.00 15.76 ? 169 LYS A NZ   1 
ATOM   2611 H H    . LYS A 1 203 ? -16.738 13.973 2.572   1.00 26.06 ? 169 LYS A H    1 
ATOM   2612 H HA   . LYS A 1 203 ? -19.153 13.796 1.552   1.00 28.23 ? 169 LYS A HA   1 
ATOM   2613 H HB2  . LYS A 1 203 ? -18.572 12.611 3.479   1.00 28.43 ? 169 LYS A HB2  1 
ATOM   2614 H HB3  . LYS A 1 203 ? -18.462 13.979 4.281   1.00 28.43 ? 169 LYS A HB3  1 
ATOM   2615 H HG2  . LYS A 1 203 ? -20.459 12.970 4.824   1.00 25.73 ? 169 LYS A HG2  1 
ATOM   2616 H HG3  . LYS A 1 203 ? -20.780 14.288 3.996   1.00 25.73 ? 169 LYS A HG3  1 
ATOM   2617 H HD2  . LYS A 1 203 ? -21.513 13.154 2.245   1.00 24.17 ? 169 LYS A HD2  1 
ATOM   2618 H HD3  . LYS A 1 203 ? -20.619 11.884 2.580   1.00 24.17 ? 169 LYS A HD3  1 
ATOM   2619 H HE2  . LYS A 1 203 ? -22.079 11.377 4.364   1.00 25.28 ? 169 LYS A HE2  1 
ATOM   2620 H HE3  . LYS A 1 203 ? -23.003 12.589 3.915   1.00 25.28 ? 169 LYS A HE3  1 
ATOM   2621 H HZ1  . LYS A 1 203 ? -23.795 10.610 3.114   1.00 18.94 ? 169 LYS A HZ1  1 
ATOM   2622 H HZ2  . LYS A 1 203 ? -23.447 11.469 2.000   1.00 18.94 ? 169 LYS A HZ2  1 
ATOM   2623 H HZ3  . LYS A 1 203 ? -22.573 10.375 2.372   1.00 18.94 ? 169 LYS A HZ3  1 
ATOM   2624 N N    . TYR A 1 204 ? -18.422 16.605 2.895   1.00 22.89 ? 170 TYR A N    1 
ATOM   2625 C CA   . TYR A 1 204 ? -18.830 18.005 2.920   1.00 20.34 ? 170 TYR A CA   1 
ATOM   2626 C C    . TYR A 1 204 ? -19.114 18.511 1.511   1.00 22.12 ? 170 TYR A C    1 
ATOM   2627 O O    . TYR A 1 204 ? -20.177 19.082 1.247   1.00 18.28 ? 170 TYR A O    1 
ATOM   2628 C CB   . TYR A 1 204 ? -17.749 18.858 3.588   1.00 19.88 ? 170 TYR A CB   1 
ATOM   2629 C CG   . TYR A 1 204 ? -18.013 20.347 3.506   1.00 21.73 ? 170 TYR A CG   1 
ATOM   2630 C CD1  . TYR A 1 204 ? -17.576 21.091 2.418   1.00 21.38 ? 170 TYR A CD1  1 
ATOM   2631 C CD2  . TYR A 1 204 ? -18.705 21.006 4.515   1.00 23.22 ? 170 TYR A CD2  1 
ATOM   2632 C CE1  . TYR A 1 204 ? -17.819 22.448 2.336   1.00 23.54 ? 170 TYR A CE1  1 
ATOM   2633 C CE2  . TYR A 1 204 ? -18.949 22.365 4.444   1.00 23.43 ? 170 TYR A CE2  1 
ATOM   2634 C CZ   . TYR A 1 204 ? -18.504 23.080 3.352   1.00 23.38 ? 170 TYR A CZ   1 
ATOM   2635 O OH   . TYR A 1 204 ? -18.745 24.432 3.273   1.00 27.47 ? 170 TYR A OH   1 
ATOM   2636 H H    . TYR A 1 204 ? -17.659 16.447 3.260   1.00 27.50 ? 170 TYR A H    1 
ATOM   2637 H HA   . TYR A 1 204 ? -19.642 18.086 3.444   1.00 24.43 ? 170 TYR A HA   1 
ATOM   2638 H HB2  . TYR A 1 204 ? -17.698 18.617 4.526   1.00 23.89 ? 170 TYR A HB2  1 
ATOM   2639 H HB3  . TYR A 1 204 ? -16.900 18.683 3.153   1.00 23.89 ? 170 TYR A HB3  1 
ATOM   2640 H HD1  . TYR A 1 204 ? -17.112 20.668 1.732   1.00 25.68 ? 170 TYR A HD1  1 
ATOM   2641 H HD2  . TYR A 1 204 ? -19.008 20.525 5.251   1.00 27.90 ? 170 TYR A HD2  1 
ATOM   2642 H HE1  . TYR A 1 204 ? -17.521 22.933 1.600   1.00 28.28 ? 170 TYR A HE1  1 
ATOM   2643 H HE2  . TYR A 1 204 ? -19.411 22.794 5.127   1.00 28.15 ? 170 TYR A HE2  1 
ATOM   2644 H HH   . TYR A 1 204 ? -19.166 24.689 3.952   1.00 32.99 ? 170 TYR A HH   1 
ATOM   2645 N N    . ASP A 1 205 ? -18.171 18.302 0.588   1.00 22.36 ? 171 ASP A N    1 
ATOM   2646 C CA   . ASP A 1 205 ? -18.357 18.777 -0.779  1.00 16.62 ? 171 ASP A CA   1 
ATOM   2647 C C    . ASP A 1 205 ? -19.592 18.153 -1.418  1.00 22.95 ? 171 ASP A C    1 
ATOM   2648 O O    . ASP A 1 205 ? -20.366 18.841 -2.094  1.00 20.39 ? 171 ASP A O    1 
ATOM   2649 C CB   . ASP A 1 205 ? -17.113 18.474 -1.614  1.00 21.91 ? 171 ASP A CB   1 
ATOM   2650 C CG   . ASP A 1 205 ? -15.905 19.286 -1.181  1.00 23.98 ? 171 ASP A CG   1 
ATOM   2651 O OD1  . ASP A 1 205 ? -16.086 20.337 -0.531  1.00 23.96 ? 171 ASP A OD1  1 
ATOM   2652 O OD2  . ASP A 1 205 ? -14.771 18.872 -1.494  1.00 24.92 ? 171 ASP A OD2  1 
ATOM   2653 H H    . ASP A 1 205 ? -17.426 17.895 0.727   1.00 26.86 ? 171 ASP A H    1 
ATOM   2654 H HA   . ASP A 1 205 ? -18.482 19.739 -0.761  1.00 19.97 ? 171 ASP A HA   1 
ATOM   2655 H HB2  . ASP A 1 205 ? -16.892 17.534 -1.521  1.00 26.32 ? 171 ASP A HB2  1 
ATOM   2656 H HB3  . ASP A 1 205 ? -17.297 18.681 -2.543  1.00 26.32 ? 171 ASP A HB3  1 
ATOM   2657 N N    . ALA A 1 206 ? -19.789 16.847 -1.222  1.00 20.58 ? 172 ALA A N    1 
ATOM   2658 C CA   . ALA A 1 206 ? -20.966 16.190 -1.782  1.00 23.71 ? 172 ALA A CA   1 
ATOM   2659 C C    . ALA A 1 206 ? -22.247 16.788 -1.216  1.00 19.13 ? 172 ALA A C    1 
ATOM   2660 O O    . ALA A 1 206 ? -23.255 16.906 -1.925  1.00 20.66 ? 172 ALA A O    1 
ATOM   2661 C CB   . ALA A 1 206 ? -20.910 14.688 -1.508  1.00 19.08 ? 172 ALA A CB   1 
ATOM   2662 H H    . ALA A 1 206 ? -19.266 16.330 -0.777  1.00 24.73 ? 172 ALA A H    1 
ATOM   2663 H HA   . ALA A 1 206 ? -20.969 16.320 -2.744  1.00 28.48 ? 172 ALA A HA   1 
ATOM   2664 H HB1  . ALA A 1 206 ? -21.698 14.268 -1.887  1.00 22.92 ? 172 ALA A HB1  1 
ATOM   2665 H HB2  . ALA A 1 206 ? -20.111 14.321 -1.916  1.00 22.92 ? 172 ALA A HB2  1 
ATOM   2666 H HB3  . ALA A 1 206 ? -20.888 14.543 -0.549  1.00 22.92 ? 172 ALA A HB3  1 
ATOM   2667 N N    . ILE A 1 207 ? -22.226 17.176 0.059   1.00 12.52 ? 173 ILE A N    1 
ATOM   2668 C CA   . ILE A 1 207 ? -23.423 17.727 0.682   1.00 17.98 ? 173 ILE A CA   1 
ATOM   2669 C C    . ILE A 1 207 ? -23.691 19.137 0.167   1.00 17.55 ? 173 ILE A C    1 
ATOM   2670 O O    . ILE A 1 207 ? -24.848 19.529 -0.025  1.00 18.46 ? 173 ILE A O    1 
ATOM   2671 C CB   . ILE A 1 207 ? -23.286 17.681 2.216   1.00 19.47 ? 173 ILE A CB   1 
ATOM   2672 C CG1  . ILE A 1 207 ? -23.675 16.286 2.723   1.00 17.72 ? 173 ILE A CG1  1 
ATOM   2673 C CG2  . ILE A 1 207 ? -24.141 18.766 2.874   1.00 19.14 ? 173 ILE A CG2  1 
ATOM   2674 C CD1  . ILE A 1 207 ? -23.478 16.074 4.215   1.00 14.20 ? 173 ILE A CD1  1 
ATOM   2675 H H    . ILE A 1 207 ? -21.541 17.130 0.577   1.00 15.06 ? 173 ILE A H    1 
ATOM   2676 H HA   . ILE A 1 207 ? -24.186 17.181 0.437   1.00 21.60 ? 173 ILE A HA   1 
ATOM   2677 H HB   . ILE A 1 207 ? -22.362 17.855 2.453   1.00 23.39 ? 173 ILE A HB   1 
ATOM   2678 H HG12 . ILE A 1 207 ? -24.614 16.139 2.529   1.00 21.29 ? 173 ILE A HG12 1 
ATOM   2679 H HG13 . ILE A 1 207 ? -23.134 15.628 2.260   1.00 21.29 ? 173 ILE A HG13 1 
ATOM   2680 H HG21 . ILE A 1 207 ? -24.203 18.585 3.825   1.00 23.00 ? 173 ILE A HG21 1 
ATOM   2681 H HG22 . ILE A 1 207 ? -23.723 19.629 2.729   1.00 23.00 ? 173 ILE A HG22 1 
ATOM   2682 H HG23 . ILE A 1 207 ? -25.026 18.755 2.477   1.00 23.00 ? 173 ILE A HG23 1 
ATOM   2683 H HD11 . ILE A 1 207 ? -23.412 15.123 4.392   1.00 17.06 ? 173 ILE A HD11 1 
ATOM   2684 H HD12 . ILE A 1 207 ? -22.662 16.520 4.492   1.00 17.06 ? 173 ILE A HD12 1 
ATOM   2685 H HD13 . ILE A 1 207 ? -24.237 16.447 4.690   1.00 17.06 ? 173 ILE A HD13 1 
ATOM   2686 N N    . GLN A 1 208 ? -22.636 19.922 -0.074  1.00 18.54 ? 174 GLN A N    1 
ATOM   2687 C CA   . GLN A 1 208 ? -22.840 21.245 -0.657  1.00 17.58 ? 174 GLN A CA   1 
ATOM   2688 C C    . GLN A 1 208 ? -23.467 21.135 -2.042  1.00 18.94 ? 174 GLN A C    1 
ATOM   2689 O O    . GLN A 1 208 ? -24.406 21.870 -2.368  1.00 16.09 ? 174 GLN A O    1 
ATOM   2690 C CB   . GLN A 1 208 ? -21.520 22.014 -0.731  1.00 17.90 ? 174 GLN A CB   1 
ATOM   2691 C CG   . GLN A 1 208 ? -20.780 22.151 0.597   1.00 17.93 ? 174 GLN A CG   1 
ATOM   2692 C CD   . GLN A 1 208 ? -21.683 22.573 1.738   1.00 20.03 ? 174 GLN A CD   1 
ATOM   2693 O OE1  . GLN A 1 208 ? -22.435 23.537 1.621   1.00 22.39 ? 174 GLN A OE1  1 
ATOM   2694 N NE2  . GLN A 1 208 ? -21.613 21.851 2.849   1.00 20.66 ? 174 GLN A NE2  1 
ATOM   2695 H H    . GLN A 1 208 ? -21.817 19.716 0.087   1.00 22.28 ? 174 GLN A H    1 
ATOM   2696 H HA   . GLN A 1 208 ? -23.439 21.747 -0.083  1.00 21.12 ? 174 GLN A HA   1 
ATOM   2697 H HB2  . GLN A 1 208 ? -20.929 21.553 -1.346  1.00 21.51 ? 174 GLN A HB2  1 
ATOM   2698 H HB3  . GLN A 1 208 ? -21.703 22.910 -1.055  1.00 21.51 ? 174 GLN A HB3  1 
ATOM   2699 H HG2  . GLN A 1 208 ? -20.388 21.294 0.828   1.00 21.55 ? 174 GLN A HG2  1 
ATOM   2700 H HG3  . GLN A 1 208 ? -20.085 22.820 0.503   1.00 21.55 ? 174 GLN A HG3  1 
ATOM   2701 H HE21 . GLN A 1 208 ? -21.075 21.182 2.894   1.00 24.82 ? 174 GLN A HE21 1 
ATOM   2702 H HE22 . GLN A 1 208 ? -22.107 22.052 3.524   1.00 24.82 ? 174 GLN A HE22 1 
ATOM   2703 N N    . GLN A 1 209 ? -22.963 20.217 -2.870  1.00 19.18 ? 175 GLN A N    1 
ATOM   2704 C CA   . GLN A 1 209 ? -23.589 19.975 -4.166  1.00 19.64 ? 175 GLN A CA   1 
ATOM   2705 C C    . GLN A 1 209 ? -25.012 19.458 -3.995  1.00 19.48 ? 175 GLN A C    1 
ATOM   2706 O O    . GLN A 1 209 ? -25.922 19.864 -4.728  1.00 20.12 ? 175 GLN A O    1 
ATOM   2707 C CB   . GLN A 1 209 ? -22.752 18.983 -4.973  1.00 21.51 ? 175 GLN A CB   1 
ATOM   2708 C CG   . GLN A 1 209 ? -23.359 18.602 -6.317  1.00 25.19 ? 175 GLN A CG   1 
ATOM   2709 C CD   . GLN A 1 209 ? -23.458 19.781 -7.261  1.00 25.30 ? 175 GLN A CD   1 
ATOM   2710 O OE1  . GLN A 1 209 ? -22.515 20.562 -7.397  1.00 29.24 ? 175 GLN A OE1  1 
ATOM   2711 N NE2  . GLN A 1 209 ? -24.606 19.922 -7.915  1.00 33.77 ? 175 GLN A NE2  1 
ATOM   2712 H H    . GLN A 1 209 ? -22.272 19.732 -2.708  1.00 23.05 ? 175 GLN A H    1 
ATOM   2713 H HA   . GLN A 1 209 ? -23.626 20.809 -4.660  1.00 23.60 ? 175 GLN A HA   1 
ATOM   2714 H HB2  . GLN A 1 209 ? -21.883 19.377 -5.144  1.00 25.84 ? 175 GLN A HB2  1 
ATOM   2715 H HB3  . GLN A 1 209 ? -22.651 18.169 -4.455  1.00 25.84 ? 175 GLN A HB3  1 
ATOM   2716 H HG2  . GLN A 1 209 ? -22.803 17.927 -6.736  1.00 30.25 ? 175 GLN A HG2  1 
ATOM   2717 H HG3  . GLN A 1 209 ? -24.253 18.254 -6.175  1.00 30.25 ? 175 GLN A HG3  1 
ATOM   2718 H HE21 . GLN A 1 209 ? -25.243 19.358 -7.791  1.00 40.55 ? 175 GLN A HE21 1 
ATOM   2719 H HE22 . GLN A 1 209 ? -24.711 20.576 -8.463  1.00 40.55 ? 175 GLN A HE22 1 
ATOM   2720 N N    . GLY A 1 210 ? -25.223 18.556 -3.034  1.00 18.56 ? 176 GLY A N    1 
ATOM   2721 C CA   . GLY A 1 210 ? -26.558 18.038 -2.800  1.00 16.65 ? 176 GLY A CA   1 
ATOM   2722 C C    . GLY A 1 210 ? -27.559 19.122 -2.457  1.00 17.58 ? 176 GLY A C    1 
ATOM   2723 O O    . GLY A 1 210 ? -28.747 18.996 -2.766  1.00 15.97 ? 176 GLY A O    1 
ATOM   2724 H H    . GLY A 1 210 ? -24.616 18.237 -2.515  1.00 22.30 ? 176 GLY A H    1 
ATOM   2725 H HA2  . GLY A 1 210 ? -26.867 17.581 -3.597  1.00 20.01 ? 176 GLY A HA2  1 
ATOM   2726 H HA3  . GLY A 1 210 ? -26.531 17.407 -2.064  1.00 20.01 ? 176 GLY A HA3  1 
ATOM   2727 N N    . LEU A 1 211 ? -27.101 20.198 -1.816  1.00 19.15 ? 177 LEU A N    1 
ATOM   2728 C CA   . LEU A 1 211 ? -27.991 21.316 -1.525  1.00 16.91 ? 177 LEU A CA   1 
ATOM   2729 C C    . LEU A 1 211 ? -28.463 21.981 -2.812  1.00 21.08 ? 177 LEU A C    1 
ATOM   2730 O O    . LEU A 1 211 ? -29.665 22.192 -3.010  1.00 17.13 ? 177 LEU A O    1 
ATOM   2731 C CB   . LEU A 1 211 ? -27.285 22.325 -0.622  1.00 17.82 ? 177 LEU A CB   1 
ATOM   2732 C CG   . LEU A 1 211 ? -28.093 23.568 -0.244  1.00 20.52 ? 177 LEU A CG   1 
ATOM   2733 C CD1  . LEU A 1 211 ? -29.427 23.182 0.377   1.00 21.93 ? 177 LEU A CD1  1 
ATOM   2734 C CD2  . LEU A 1 211 ? -27.291 24.453 0.700   1.00 20.65 ? 177 LEU A CD2  1 
ATOM   2735 H H    . LEU A 1 211 ? -26.291 20.302 -1.544  1.00 23.00 ? 177 LEU A H    1 
ATOM   2736 H HA   . LEU A 1 211 ? -28.770 20.986 -1.052  1.00 20.32 ? 177 LEU A HA   1 
ATOM   2737 H HB2  . LEU A 1 211 ? -27.046 21.876 0.204   1.00 21.41 ? 177 LEU A HB2  1 
ATOM   2738 H HB3  . LEU A 1 211 ? -26.484 22.631 -1.077  1.00 21.41 ? 177 LEU A HB3  1 
ATOM   2739 H HG   . LEU A 1 211 ? -28.282 24.077 -1.048  1.00 24.65 ? 177 LEU A HG   1 
ATOM   2740 H HD11 . LEU A 1 211 ? -29.858 23.981 0.720   1.00 26.35 ? 177 LEU A HD11 1 
ATOM   2741 H HD12 . LEU A 1 211 ? -29.984 22.771 -0.302  1.00 26.35 ? 177 LEU A HD12 1 
ATOM   2742 H HD13 . LEU A 1 211 ? -29.269 22.555 1.100   1.00 26.35 ? 177 LEU A HD13 1 
ATOM   2743 H HD21 . LEU A 1 211 ? -27.833 25.217 0.954   1.00 24.81 ? 177 LEU A HD21 1 
ATOM   2744 H HD22 . LEU A 1 211 ? -27.053 23.940 1.488   1.00 24.81 ? 177 LEU A HD22 1 
ATOM   2745 H HD23 . LEU A 1 211 ? -26.488 24.753 0.246   1.00 24.81 ? 177 LEU A HD23 1 
ATOM   2746 N N    . LYS A 1 212 ? -27.526 22.316 -3.703  1.00 16.78 ? 178 LYS A N    1 
ATOM   2747 C CA   . LYS A 1 212 ? -27.908 22.885 -4.992  1.00 21.60 ? 178 LYS A CA   1 
ATOM   2748 C C    . LYS A 1 212 ? -28.871 21.964 -5.728  1.00 20.08 ? 178 LYS A C    1 
ATOM   2749 O O    . LYS A 1 212 ? -29.860 22.424 -6.312  1.00 21.55 ? 178 LYS A O    1 
ATOM   2750 C CB   . LYS A 1 212 ? -26.663 23.147 -5.838  1.00 24.81 ? 178 LYS A CB   1 
ATOM   2751 C CG   . LYS A 1 212 ? -25.877 24.374 -5.410  1.00 32.14 ? 178 LYS A CG   1 
ATOM   2752 C CD   . LYS A 1 212 ? -24.462 24.354 -5.965  1.00 38.14 ? 178 LYS A CD   1 
ATOM   2753 C CE   . LYS A 1 212 ? -23.611 25.451 -5.344  1.00 44.41 ? 178 LYS A CE   1 
ATOM   2754 N NZ   . LYS A 1 212 ? -22.772 24.943 -4.224  1.00 36.82 ? 178 LYS A NZ   1 
ATOM   2755 H H    . LYS A 1 212 ? -26.679 22.226 -3.587  1.00 20.17 ? 178 LYS A H    1 
ATOM   2756 H HA   . LYS A 1 212 ? -28.353 23.733 -4.843  1.00 25.94 ? 178 LYS A HA   1 
ATOM   2757 H HB2  . LYS A 1 212 ? -26.074 22.380 -5.772  1.00 29.79 ? 178 LYS A HB2  1 
ATOM   2758 H HB3  . LYS A 1 212 ? -26.936 23.278 -6.760  1.00 29.79 ? 178 LYS A HB3  1 
ATOM   2759 H HG2  . LYS A 1 212 ? -26.321 25.171 -5.738  1.00 38.60 ? 178 LYS A HG2  1 
ATOM   2760 H HG3  . LYS A 1 212 ? -25.824 24.399 -4.442  1.00 38.60 ? 178 LYS A HG3  1 
ATOM   2761 H HD2  . LYS A 1 212 ? -24.051 23.498 -5.766  1.00 45.80 ? 178 LYS A HD2  1 
ATOM   2762 H HD3  . LYS A 1 212 ? -24.491 24.494 -6.924  1.00 45.80 ? 178 LYS A HD3  1 
ATOM   2763 H HE2  . LYS A 1 212 ? -23.022 25.818 -6.021  1.00 53.32 ? 178 LYS A HE2  1 
ATOM   2764 H HE3  . LYS A 1 212 ? -24.192 26.146 -4.997  1.00 53.32 ? 178 LYS A HE3  1 
ATOM   2765 H HZ1  . LYS A 1 212 ? -22.420 25.626 -3.774  1.00 44.21 ? 178 LYS A HZ1  1 
ATOM   2766 H HZ2  . LYS A 1 212 ? -23.269 24.457 -3.668  1.00 44.21 ? 178 LYS A HZ2  1 
ATOM   2767 H HZ3  . LYS A 1 212 ? -22.114 24.436 -4.542  1.00 44.21 ? 178 LYS A HZ3  1 
ATOM   2768 N N    . ASP A 1 213 ? -28.604 20.656 -5.706  1.00 19.98 ? 179 ASP A N    1 
ATOM   2769 C CA   . ASP A 1 213 ? -29.499 19.711 -6.363  1.00 22.34 ? 179 ASP A CA   1 
ATOM   2770 C C    . ASP A 1 213 ? -30.879 19.728 -5.720  1.00 19.78 ? 179 ASP A C    1 
ATOM   2771 O O    . ASP A 1 213 ? -31.898 19.691 -6.419  1.00 18.08 ? 179 ASP A O    1 
ATOM   2772 C CB   . ASP A 1 213 ? -28.901 18.305 -6.316  1.00 21.58 ? 179 ASP A CB   1 
ATOM   2773 C CG   . ASP A 1 213 ? -27.661 18.172 -7.176  1.00 23.14 ? 179 ASP A CG   1 
ATOM   2774 O OD1  . ASP A 1 213 ? -27.648 18.731 -8.292  1.00 31.95 ? 179 ASP A OD1  1 
ATOM   2775 O OD2  . ASP A 1 213 ? -26.699 17.511 -6.734  1.00 29.28 ? 179 ASP A OD2  1 
ATOM   2776 H H    . ASP A 1 213 ? -27.922 20.299 -5.323  1.00 24.00 ? 179 ASP A H    1 
ATOM   2777 H HA   . ASP A 1 213 ? -29.597 19.964 -7.295  1.00 26.84 ? 179 ASP A HA   1 
ATOM   2778 H HB2  . ASP A 1 213 ? -28.656 18.096 -5.401  1.00 25.93 ? 179 ASP A HB2  1 
ATOM   2779 H HB3  . ASP A 1 213 ? -29.559 17.670 -6.637  1.00 25.93 ? 179 ASP A HB3  1 
ATOM   2780 N N    . LEU A 1 214 ? -30.931 19.782 -4.386  1.00 18.80 ? 180 LEU A N    1 
ATOM   2781 C CA   . LEU A 1 214 ? -32.213 19.850 -3.693  1.00 17.52 ? 180 LEU A CA   1 
ATOM   2782 C C    . LEU A 1 214 ? -33.053 21.014 -4.203  1.00 19.38 ? 180 LEU A C    1 
ATOM   2783 O O    . LEU A 1 214 ? -34.258 20.866 -4.436  1.00 15.64 ? 180 LEU A O    1 
ATOM   2784 C CB   . LEU A 1 214 ? -31.986 19.975 -2.184  1.00 18.56 ? 180 LEU A CB   1 
ATOM   2785 C CG   . LEU A 1 214 ? -33.230 19.818 -1.306  1.00 16.86 ? 180 LEU A CG   1 
ATOM   2786 C CD1  . LEU A 1 214 ? -33.584 18.345 -1.144  1.00 18.80 ? 180 LEU A CD1  1 
ATOM   2787 C CD2  . LEU A 1 214 ? -33.033 20.478 0.052   1.00 14.28 ? 180 LEU A CD2  1 
ATOM   2788 H H    . LEU A 1 214 ? -30.245 19.780 -3.867  1.00 22.59 ? 180 LEU A H    1 
ATOM   2789 H HA   . LEU A 1 214 ? -32.704 19.029 -3.857  1.00 21.05 ? 180 LEU A HA   1 
ATOM   2790 H HB2  . LEU A 1 214 ? -31.355 19.290 -1.915  1.00 22.29 ? 180 LEU A HB2  1 
ATOM   2791 H HB3  . LEU A 1 214 ? -31.618 20.855 -2.005  1.00 22.29 ? 180 LEU A HB3  1 
ATOM   2792 H HG   . LEU A 1 214 ? -33.975 20.263 -1.739  1.00 20.25 ? 180 LEU A HG   1 
ATOM   2793 H HD11 . LEU A 1 214 ? -34.294 18.260 -0.489  1.00 22.59 ? 180 LEU A HD11 1 
ATOM   2794 H HD12 . LEU A 1 214 ? -33.879 17.995 -2.000  1.00 22.59 ? 180 LEU A HD12 1 
ATOM   2795 H HD13 . LEU A 1 214 ? -32.798 17.862 -0.844  1.00 22.59 ? 180 LEU A HD13 1 
ATOM   2796 H HD21 . LEU A 1 214 ? -33.863 20.427 0.552   1.00 17.16 ? 180 LEU A HD21 1 
ATOM   2797 H HD22 . LEU A 1 214 ? -32.330 20.012 0.531   1.00 17.16 ? 180 LEU A HD22 1 
ATOM   2798 H HD23 . LEU A 1 214 ? -32.784 21.406 -0.081  1.00 17.16 ? 180 LEU A HD23 1 
ATOM   2799 N N    . ILE A 1 215 ? -32.433 22.183 -4.383  1.00 17.06 ? 181 ILE A N    1 
ATOM   2800 C CA   . ILE A 1 215 ? -33.163 23.339 -4.894  1.00 16.80 ? 181 ILE A CA   1 
ATOM   2801 C C    . ILE A 1 215 ? -33.668 23.059 -6.303  1.00 22.15 ? 181 ILE A C    1 
ATOM   2802 O O    . ILE A 1 215 ? -34.852 23.244 -6.608  1.00 17.45 ? 181 ILE A O    1 
ATOM   2803 C CB   . ILE A 1 215 ? -32.276 24.597 -4.859  1.00 17.09 ? 181 ILE A CB   1 
ATOM   2804 C CG1  . ILE A 1 215 ? -31.801 24.885 -3.435  1.00 17.39 ? 181 ILE A CG1  1 
ATOM   2805 C CG2  . ILE A 1 215 ? -33.036 25.796 -5.415  1.00 19.68 ? 181 ILE A CG2  1 
ATOM   2806 C CD1  . ILE A 1 215 ? -30.733 25.951 -3.360  1.00 17.80 ? 181 ILE A CD1  1 
ATOM   2807 H H    . ILE A 1 215 ? -31.602 22.329 -4.218  1.00 20.50 ? 181 ILE A H    1 
ATOM   2808 H HA   . ILE A 1 215 ? -33.930 23.497 -4.321  1.00 20.19 ? 181 ILE A HA   1 
ATOM   2809 H HB   . ILE A 1 215 ? -31.498 24.433 -5.415  1.00 20.53 ? 181 ILE A HB   1 
ATOM   2810 H HG12 . ILE A 1 215 ? -32.558 25.186 -2.907  1.00 20.89 ? 181 ILE A HG12 1 
ATOM   2811 H HG13 . ILE A 1 215 ? -31.435 24.071 -3.056  1.00 20.89 ? 181 ILE A HG13 1 
ATOM   2812 H HG21 . ILE A 1 215 ? -32.509 26.597 -5.272  1.00 23.64 ? 181 ILE A HG21 1 
ATOM   2813 H HG22 . ILE A 1 215 ? -33.186 25.662 -6.364  1.00 23.64 ? 181 ILE A HG22 1 
ATOM   2814 H HG23 . ILE A 1 215 ? -33.886 25.872 -4.953  1.00 23.64 ? 181 ILE A HG23 1 
ATOM   2815 H HD11 . ILE A 1 215 ? -30.267 25.873 -2.513  1.00 21.39 ? 181 ILE A HD11 1 
ATOM   2816 H HD12 . ILE A 1 215 ? -30.110 25.825 -4.093  1.00 21.39 ? 181 ILE A HD12 1 
ATOM   2817 H HD13 . ILE A 1 215 ? -31.152 26.823 -3.428  1.00 21.39 ? 181 ILE A HD13 1 
ATOM   2818 N N    . ALA A 1 216 ? -32.770 22.616 -7.186  1.00 19.09 ? 182 ALA A N    1 
ATOM   2819 C CA   . ALA A 1 216 ? -33.170 22.307 -8.554  1.00 20.20 ? 182 ALA A CA   1 
ATOM   2820 C C    . ALA A 1 216 ? -34.284 21.270 -8.576  1.00 16.80 ? 182 ALA A C    1 
ATOM   2821 O O    . ALA A 1 216 ? -35.246 21.396 -9.344  1.00 19.10 ? 182 ALA A O    1 
ATOM   2822 C CB   . ALA A 1 216 ? -31.965 21.814 -9.353  1.00 21.40 ? 182 ALA A CB   1 
ATOM   2823 H H    . ALA A 1 216 ? -31.935 22.489 -7.019  1.00 22.93 ? 182 ALA A H    1 
ATOM   2824 H HA   . ALA A 1 216 ? -33.501 23.116 -8.975  1.00 24.26 ? 182 ALA A HA   1 
ATOM   2825 H HB1  . ALA A 1 216 ? -32.247 21.616 -10.260 1.00 25.71 ? 182 ALA A HB1  1 
ATOM   2826 H HB2  . ALA A 1 216 ? -31.287 22.507 -9.361  1.00 25.71 ? 182 ALA A HB2  1 
ATOM   2827 H HB3  . ALA A 1 216 ? -31.615 21.013 -8.934  1.00 25.71 ? 182 ALA A HB3  1 
ATOM   2828 N N    . GLU A 1 217 ? -34.173 20.238 -7.738  1.00 17.80 ? 183 GLU A N    1 
ATOM   2829 C CA   . GLU A 1 217 ? -35.201 19.205 -7.706  1.00 15.09 ? 183 GLU A CA   1 
ATOM   2830 C C    . GLU A 1 217 ? -36.505 19.738 -7.127  1.00 16.97 ? 183 GLU A C    1 
ATOM   2831 O O    . GLU A 1 217 ? -37.587 19.309 -7.542  1.00 14.53 ? 183 GLU A O    1 
ATOM   2832 C CB   . GLU A 1 217 ? -34.701 18.000 -6.908  1.00 18.24 ? 183 GLU A CB   1 
ATOM   2833 C CG   . GLU A 1 217 ? -33.604 17.212 -7.625  1.00 22.32 ? 183 GLU A CG   1 
ATOM   2834 C CD   . GLU A 1 217 ? -32.628 16.537 -6.675  1.00 21.25 ? 183 GLU A CD   1 
ATOM   2835 O OE1  . GLU A 1 217 ? -32.915 16.473 -5.460  1.00 20.42 ? 183 GLU A OE1  1 
ATOM   2836 O OE2  . GLU A 1 217 ? -31.569 16.070 -7.147  1.00 22.73 ? 183 GLU A OE2  1 
ATOM   2837 H H    . GLU A 1 217 ? -33.524 20.116 -7.189  1.00 21.39 ? 183 GLU A H    1 
ATOM   2838 H HA   . GLU A 1 217 ? -35.383 18.904 -8.610  1.00 18.14 ? 183 GLU A HA   1 
ATOM   2839 H HB2  . GLU A 1 217 ? -34.340 18.311 -6.063  1.00 21.91 ? 183 GLU A HB2  1 
ATOM   2840 H HB3  . GLU A 1 217 ? -35.444 17.398 -6.749  1.00 21.91 ? 183 GLU A HB3  1 
ATOM   2841 H HG2  . GLU A 1 217 ? -34.016 16.522 -8.167  1.00 26.81 ? 183 GLU A HG2  1 
ATOM   2842 H HG3  . GLU A 1 217 ? -33.099 17.819 -8.188  1.00 26.81 ? 183 GLU A HG3  1 
ATOM   2843 N N    . THR A 1 218 ? -36.426 20.678 -6.181  1.00 18.49 ? 184 THR A N    1 
ATOM   2844 C CA   . THR A 1 218 ? -37.638 21.308 -5.668  1.00 16.30 ? 184 THR A CA   1 
ATOM   2845 C C    . THR A 1 218 ? -38.321 22.142 -6.746  1.00 17.88 ? 184 THR A C    1 
ATOM   2846 O O    . THR A 1 218 ? -39.549 22.103 -6.884  1.00 14.69 ? 184 THR A O    1 
ATOM   2847 C CB   . THR A 1 218 ? -37.308 22.175 -4.453  1.00 17.16 ? 184 THR A CB   1 
ATOM   2848 O OG1  . THR A 1 218 ? -36.657 21.377 -3.456  1.00 15.72 ? 184 THR A OG1  1 
ATOM   2849 C CG2  . THR A 1 218 ? -38.576 22.783 -3.864  1.00 18.94 ? 184 THR A CG2  1 
ATOM   2850 H H    . THR A 1 218 ? -35.696 20.962 -5.827  1.00 22.21 ? 184 THR A H    1 
ATOM   2851 H HA   . THR A 1 218 ? -38.254 20.615 -5.383  1.00 19.59 ? 184 THR A HA   1 
ATOM   2852 H HB   . THR A 1 218 ? -36.721 22.898 -4.724  1.00 20.62 ? 184 THR A HB   1 
ATOM   2853 H HG1  . THR A 1 218 ? -35.950 21.048 -3.768  1.00 18.90 ? 184 THR A HG1  1 
ATOM   2854 H HG21 . THR A 1 218 ? -38.373 23.223 -3.024  1.00 22.75 ? 184 THR A HG21 1 
ATOM   2855 H HG22 . THR A 1 218 ? -38.949 23.434 -4.479  1.00 22.75 ? 184 THR A HG22 1 
ATOM   2856 H HG23 . THR A 1 218 ? -39.234 22.088 -3.704  1.00 22.75 ? 184 THR A HG23 1 
ATOM   2857 N N    . ARG A 1 219 ? -37.542 22.902 -7.521  1.00 18.23 ? 185 ARG A N    1 
ATOM   2858 C CA   . ARG A 1 219 ? -38.128 23.691 -8.599  1.00 15.78 ? 185 ARG A CA   1 
ATOM   2859 C C    . ARG A 1 219 ? -38.800 22.793 -9.631  1.00 17.79 ? 185 ARG A C    1 
ATOM   2860 O O    . ARG A 1 219 ? -39.910 23.085 -10.093 1.00 18.76 ? 185 ARG A O    1 
ATOM   2861 C CB   . ARG A 1 219 ? -37.056 24.559 -9.258  1.00 19.85 ? 185 ARG A CB   1 
ATOM   2862 C CG   . ARG A 1 219 ? -37.511 25.278 -10.527 1.00 20.96 ? 185 ARG A CG   1 
ATOM   2863 C CD   . ARG A 1 219 ? -38.724 26.166 -10.277 1.00 23.29 ? 185 ARG A CD   1 
ATOM   2864 N NE   . ARG A 1 219 ? -38.408 27.295 -9.410  1.00 19.63 ? 185 ARG A NE   1 
ATOM   2865 C CZ   . ARG A 1 219 ? -39.313 28.089 -8.854  1.00 19.90 ? 185 ARG A CZ   1 
ATOM   2866 N NH1  . ARG A 1 219 ? -40.609 27.897 -9.037  1.00 23.27 ? 185 ARG A NH1  1 
ATOM   2867 N NH2  . ARG A 1 219 ? -38.907 29.103 -8.096  1.00 18.20 ? 185 ARG A NH2  1 
ATOM   2868 H H    . ARG A 1 219 ? -36.689 22.975 -7.443  1.00 21.91 ? 185 ARG A H    1 
ATOM   2869 H HA   . ARG A 1 219 ? -38.803 24.280 -8.227  1.00 18.97 ? 185 ARG A HA   1 
ATOM   2870 H HB2  . ARG A 1 219 ? -36.774 25.236 -8.623  1.00 23.84 ? 185 ARG A HB2  1 
ATOM   2871 H HB3  . ARG A 1 219 ? -36.304 23.994 -9.495  1.00 23.84 ? 185 ARG A HB3  1 
ATOM   2872 H HG2  . ARG A 1 219 ? -36.789 25.837 -10.853 1.00 25.18 ? 185 ARG A HG2  1 
ATOM   2873 H HG3  . ARG A 1 219 ? -37.751 24.620 -11.198 1.00 25.18 ? 185 ARG A HG3  1 
ATOM   2874 H HD2  . ARG A 1 219 ? -39.043 26.515 -11.124 1.00 27.98 ? 185 ARG A HD2  1 
ATOM   2875 H HD3  . ARG A 1 219 ? -39.420 25.642 -9.851  1.00 27.98 ? 185 ARG A HD3  1 
ATOM   2876 H HE   . ARG A 1 219 ? -37.579 27.457 -9.249  1.00 23.58 ? 185 ARG A HE   1 
ATOM   2877 H HH11 . ARG A 1 219 ? -40.882 27.244 -9.526  1.00 27.95 ? 185 ARG A HH11 1 
ATOM   2878 H HH12 . ARG A 1 219 ? -41.178 28.424 -8.666  1.00 27.95 ? 185 ARG A HH12 1 
ATOM   2879 H HH21 . ARG A 1 219 ? -38.066 29.238 -7.971  1.00 21.87 ? 185 ARG A HH21 1 
ATOM   2880 H HH22 . ARG A 1 219 ? -39.484 29.625 -7.730  1.00 21.87 ? 185 ARG A HH22 1 
ATOM   2881 N N    . ALA A 1 220 ? -38.142 21.695 -10.008 1.00 19.30 ? 186 ALA A N    1 
ATOM   2882 C CA   . ALA A 1 220 ? -38.744 20.770 -10.960 1.00 20.76 ? 186 ALA A CA   1 
ATOM   2883 C C    . ALA A 1 220 ? -40.049 20.194 -10.428 1.00 21.28 ? 186 ALA A C    1 
ATOM   2884 O O    . ALA A 1 220 ? -40.961 19.896 -11.208 1.00 18.05 ? 186 ALA A O    1 
ATOM   2885 C CB   . ALA A 1 220 ? -37.765 19.643 -11.286 1.00 18.53 ? 186 ALA A CB   1 
ATOM   2886 H H    . ALA A 1 220 ? -37.360 21.469 -9.731  1.00 23.19 ? 186 ALA A H    1 
ATOM   2887 H HA   . ALA A 1 220 ? -38.938 21.248 -11.781 1.00 24.94 ? 186 ALA A HA   1 
ATOM   2888 H HB1  . ALA A 1 220 ? -38.169 19.054 -11.942 1.00 22.27 ? 186 ALA A HB1  1 
ATOM   2889 H HB2  . ALA A 1 220 ? -36.949 20.027 -11.644 1.00 22.27 ? 186 ALA A HB2  1 
ATOM   2890 H HB3  . ALA A 1 220 ? -37.570 19.149 -10.474 1.00 22.27 ? 186 ALA A HB3  1 
ATOM   2891 N N    . ALA A 1 221 ? -40.164 20.040 -9.108  1.00 19.81 ? 187 ALA A N    1 
ATOM   2892 C CA   . ALA A 1 221 ? -41.345 19.406 -8.536  1.00 16.88 ? 187 ALA A CA   1 
ATOM   2893 C C    . ALA A 1 221 ? -42.524 20.371 -8.474  1.00 22.00 ? 187 ALA A C    1 
ATOM   2894 O O    . ALA A 1 221 ? -43.649 20.008 -8.838  1.00 18.18 ? 187 ALA A O    1 
ATOM   2895 C CB   . ALA A 1 221 ? -41.023 18.864 -7.142  1.00 19.70 ? 187 ALA A CB   1 
ATOM   2896 H H    . ALA A 1 221 ? -39.577 20.291 -8.531  1.00 23.80 ? 187 ALA A H    1 
ATOM   2897 H HA   . ALA A 1 221 ? -41.601 18.660 -9.100  1.00 20.28 ? 187 ALA A HA   1 
ATOM   2898 H HB1  . ALA A 1 221 ? -41.798 18.390 -6.801  1.00 23.66 ? 187 ALA A HB1  1 
ATOM   2899 H HB2  . ALA A 1 221 ? -40.267 18.259 -7.206  1.00 23.66 ? 187 ALA A HB2  1 
ATOM   2900 H HB3  . ALA A 1 221 ? -40.805 19.606 -6.557  1.00 23.66 ? 187 ALA A HB3  1 
ATOM   2901 N N    . ILE A 1 222 ? -42.291 21.608 -8.020  1.00 19.99 ? 188 ILE A N    1 
ATOM   2902 C CA   . ILE A 1 222 ? -43.395 22.541 -7.802  1.00 20.28 ? 188 ILE A CA   1 
ATOM   2903 C C    . ILE A 1 222 ? -43.733 23.367 -9.035  1.00 21.86 ? 188 ILE A C    1 
ATOM   2904 O O    . ILE A 1 222 ? -44.727 24.111 -9.015  1.00 21.62 ? 188 ILE A O    1 
ATOM   2905 C CB   . ILE A 1 222 ? -43.101 23.483 -6.615  1.00 17.11 ? 188 ILE A CB   1 
ATOM   2906 C CG1  . ILE A 1 222 ? -41.980 24.473 -6.944  1.00 18.94 ? 188 ILE A CG1  1 
ATOM   2907 C CG2  . ILE A 1 222 ? -42.739 22.672 -5.378  1.00 20.74 ? 188 ILE A CG2  1 
ATOM   2908 C CD1  . ILE A 1 222 ? -41.757 25.505 -5.856  1.00 17.07 ? 188 ILE A CD1  1 
ATOM   2909 H H    . ILE A 1 222 ? -41.513 21.924 -7.835  1.00 24.02 ? 188 ILE A H    1 
ATOM   2910 H HA   . ILE A 1 222 ? -44.180 22.014 -7.584  1.00 24.36 ? 188 ILE A HA   1 
ATOM   2911 H HB   . ILE A 1 222 ? -43.907 23.994 -6.440  1.00 20.56 ? 188 ILE A HB   1 
ATOM   2912 H HG12 . ILE A 1 222 ? -41.152 23.982 -7.064  1.00 22.76 ? 188 ILE A HG12 1 
ATOM   2913 H HG13 . ILE A 1 222 ? -42.207 24.944 -7.761  1.00 22.76 ? 188 ILE A HG13 1 
ATOM   2914 H HG21 . ILE A 1 222 ? -42.779 23.249 -4.599  1.00 24.92 ? 188 ILE A HG21 1 
ATOM   2915 H HG22 . ILE A 1 222 ? -43.372 21.943 -5.282  1.00 24.92 ? 188 ILE A HG22 1 
ATOM   2916 H HG23 . ILE A 1 222 ? -41.842 22.319 -5.483  1.00 24.92 ? 188 ILE A HG23 1 
ATOM   2917 H HD11 . ILE A 1 222 ? -41.132 26.173 -6.177  1.00 20.52 ? 188 ILE A HD11 1 
ATOM   2918 H HD12 . ILE A 1 222 ? -42.605 25.923 -5.639  1.00 20.52 ? 188 ILE A HD12 1 
ATOM   2919 H HD13 . ILE A 1 222 ? -41.396 25.064 -5.071  1.00 20.52 ? 188 ILE A HD13 1 
ATOM   2920 N N    . GLY A 1 223 ? -42.953 23.264 -10.103 1.00 22.77 ? 189 GLY A N    1 
ATOM   2921 C CA   . GLY A 1 223 ? -43.266 23.972 -11.323 1.00 22.85 ? 189 GLY A CA   1 
ATOM   2922 C C    . GLY A 1 223 ? -42.879 25.437 -11.264 1.00 27.57 ? 189 GLY A C    1 
ATOM   2923 O O    . GLY A 1 223 ? -42.196 25.909 -10.349 1.00 25.85 ? 189 GLY A O    1 
ATOM   2924 H H    . GLY A 1 223 ? -42.237 22.788 -10.141 1.00 27.35 ? 189 GLY A H    1 
ATOM   2925 H HA2  . GLY A 1 223 ? -42.790 23.561 -12.062 1.00 27.44 ? 189 GLY A HA2  1 
ATOM   2926 H HA3  . GLY A 1 223 ? -44.219 23.915 -11.490 1.00 27.44 ? 189 GLY A HA3  1 
ATOM   2927 N N    . GLU A 1 224 ? -43.349 26.172 -12.269 1.00 26.01 ? 190 GLU A N    1 
ATOM   2928 C CA   . GLU A 1 224 ? -42.954 27.557 -12.479 1.00 29.91 ? 190 GLU A CA   1 
ATOM   2929 C C    . GLU A 1 224 ? -43.939 28.566 -11.901 1.00 22.48 ? 190 GLU A C    1 
ATOM   2930 O O    . GLU A 1 224 ? -43.659 29.767 -11.939 1.00 25.48 ? 190 GLU A O    1 
ATOM   2931 C CB   . GLU A 1 224 ? -42.767 27.820 -13.979 1.00 34.74 ? 190 GLU A CB   1 
ATOM   2932 C CG   . GLU A 1 224 ? -44.022 27.599 -14.822 1.00 41.64 ? 190 GLU A CG   1 
ATOM   2933 C CD   . GLU A 1 224 ? -44.039 26.254 -15.535 1.00 54.44 ? 190 GLU A CD   1 
ATOM   2934 O OE1  . GLU A 1 224 ? -45.097 25.895 -16.096 1.00 50.43 ? 190 GLU A OE1  1 
ATOM   2935 O OE2  . GLU A 1 224 ? -43.005 25.551 -15.529 1.00 49.29 ? 190 GLU A OE2  1 
ATOM   2936 H H    . GLU A 1 224 ? -43.910 25.882 -12.854 1.00 31.24 ? 190 GLU A H    1 
ATOM   2937 H HA   . GLU A 1 224 ? -42.104 27.702 -12.034 1.00 35.92 ? 190 GLU A HA   1 
ATOM   2938 H HB2  . GLU A 1 224 ? -42.491 28.742 -14.099 1.00 41.72 ? 190 GLU A HB2  1 
ATOM   2939 H HB3  . GLU A 1 224 ? -42.080 27.222 -14.314 1.00 41.72 ? 190 GLU A HB3  1 
ATOM   2940 H HG2  . GLU A 1 224 ? -44.800 27.640 -14.243 1.00 49.99 ? 190 GLU A HG2  1 
ATOM   2941 H HG3  . GLU A 1 224 ? -44.074 28.294 -15.496 1.00 49.99 ? 190 GLU A HG3  1 
ATOM   2942 N N    . ASP A 1 225 ? -45.077 28.119 -11.369 1.00 22.80 ? 191 ASP A N    1 
ATOM   2943 C CA   . ASP A 1 225 ? -46.066 29.025 -10.800 1.00 22.55 ? 191 ASP A CA   1 
ATOM   2944 C C    . ASP A 1 225 ? -45.873 29.270 -9.309  1.00 21.36 ? 191 ASP A C    1 
ATOM   2945 O O    . ASP A 1 225 ? -46.548 30.142 -8.751  1.00 19.66 ? 191 ASP A O    1 
ATOM   2946 C CB   . ASP A 1 225 ? -47.482 28.479 -11.025 1.00 27.94 ? 191 ASP A CB   1 
ATOM   2947 C CG   . ASP A 1 225 ? -47.804 28.272 -12.489 1.00 40.46 ? 191 ASP A CG   1 
ATOM   2948 O OD1  . ASP A 1 225 ? -47.281 29.035 -13.328 1.00 40.13 ? 191 ASP A OD1  1 
ATOM   2949 O OD2  . ASP A 1 225 ? -48.585 27.347 -12.799 1.00 43.01 ? 191 ASP A OD2  1 
ATOM   2950 H H    . ASP A 1 225 ? -45.298 27.289 -11.327 1.00 27.38 ? 191 ASP A H    1 
ATOM   2951 H HA   . ASP A 1 225 ? -45.990 29.876 -11.259 1.00 27.09 ? 191 ASP A HA   1 
ATOM   2952 H HB2  . ASP A 1 225 ? -47.566 27.624 -10.575 1.00 33.55 ? 191 ASP A HB2  1 
ATOM   2953 H HB3  . ASP A 1 225 ? -48.125 29.109 -10.663 1.00 33.55 ? 191 ASP A HB3  1 
ATOM   2954 N N    . HIS A 1 226 ? -44.978 28.539 -8.654  1.00 13.98 ? 192 HIS A N    1 
ATOM   2955 C CA   . HIS A 1 226 ? -44.855 28.576 -7.206  1.00 19.44 ? 192 HIS A CA   1 
ATOM   2956 C C    . HIS A 1 226 ? -43.495 29.128 -6.801  1.00 17.63 ? 192 HIS A C    1 
ATOM   2957 O O    . HIS A 1 226 ? -42.544 29.148 -7.588  1.00 18.98 ? 192 HIS A O    1 
ATOM   2958 C CB   . HIS A 1 226 ? -45.077 27.180 -6.612  1.00 14.07 ? 192 HIS A CB   1 
ATOM   2959 C CG   . HIS A 1 226 ? -46.462 26.656 -6.828  1.00 16.13 ? 192 HIS A CG   1 
ATOM   2960 N ND1  . HIS A 1 226 ? -46.714 25.435 -7.417  1.00 17.19 ? 192 HIS A ND1  1 
ATOM   2961 C CD2  . HIS A 1 226 ? -47.672 27.195 -6.549  1.00 16.42 ? 192 HIS A CD2  1 
ATOM   2962 C CE1  . HIS A 1 226 ? -48.019 25.241 -7.480  1.00 19.74 ? 192 HIS A CE1  1 
ATOM   2963 N NE2  . HIS A 1 226 ? -48.623 26.294 -6.961  1.00 22.98 ? 192 HIS A NE2  1 
ATOM   2964 H H    . HIS A 1 226 ? -44.423 28.004 -9.035  1.00 16.81 ? 192 HIS A H    1 
ATOM   2965 H HA   . HIS A 1 226 ? -45.523 29.174 -6.834  1.00 23.35 ? 192 HIS A HA   1 
ATOM   2966 H HB2  . HIS A 1 226 ? -44.456 26.561 -7.026  1.00 16.91 ? 192 HIS A HB2  1 
ATOM   2967 H HB3  . HIS A 1 226 ? -44.919 27.218 -5.655  1.00 16.91 ? 192 HIS A HB3  1 
ATOM   2968 H HD1  . HIS A 1 226 ? -46.116 24.886 -7.699  1.00 20.66 ? 192 HIS A HD1  1 
ATOM   2969 H HD2  . HIS A 1 226 ? -47.829 28.022 -6.152  1.00 19.73 ? 192 HIS A HD2  1 
ATOM   2970 H HE1  . HIS A 1 226 ? -48.441 24.490 -7.830  1.00 23.71 ? 192 HIS A HE1  1 
ATOM   2971 N N    . LEU A 1 227 ? -43.417 29.583 -5.555  1.00 15.01 ? 193 LEU A N    1 
ATOM   2972 C CA   . LEU A 1 227 ? -42.273 30.329 -5.060  1.00 16.49 ? 193 LEU A CA   1 
ATOM   2973 C C    . LEU A 1 227 ? -41.348 29.439 -4.241  1.00 14.87 ? 193 LEU A C    1 
ATOM   2974 O O    . LEU A 1 227 ? -41.782 28.492 -3.580  1.00 16.03 ? 193 LEU A O    1 
ATOM   2975 C CB   . LEU A 1 227 ? -42.733 31.510 -4.203  1.00 16.17 ? 193 LEU A CB   1 
ATOM   2976 C CG   . LEU A 1 227 ? -43.578 32.563 -4.920  1.00 16.32 ? 193 LEU A CG   1 
ATOM   2977 C CD1  . LEU A 1 227 ? -44.160 33.549 -3.920  1.00 17.43 ? 193 LEU A CD1  1 
ATOM   2978 C CD2  . LEU A 1 227 ? -42.753 33.286 -5.974  1.00 20.21 ? 193 LEU A CD2  1 
ATOM   2979 H H    . LEU A 1 227 ? -44.032 29.467 -4.965  1.00 18.04 ? 193 LEU A H    1 
ATOM   2980 H HA   . LEU A 1 227 ? -41.767 30.665 -5.816  1.00 19.81 ? 193 LEU A HA   1 
ATOM   2981 H HB2  . LEU A 1 227 ? -43.265 31.163 -3.470  1.00 19.43 ? 193 LEU A HB2  1 
ATOM   2982 H HB3  . LEU A 1 227 ? -41.946 31.959 -3.857  1.00 19.43 ? 193 LEU A HB3  1 
ATOM   2983 H HG   . LEU A 1 227 ? -44.316 32.123 -5.371  1.00 19.62 ? 193 LEU A HG   1 
ATOM   2984 H HD11 . LEU A 1 227 ? -44.745 34.165 -4.388  1.00 20.94 ? 193 LEU A HD11 1 
ATOM   2985 H HD12 . LEU A 1 227 ? -44.662 33.060 -3.250  1.00 20.94 ? 193 LEU A HD12 1 
ATOM   2986 H HD13 . LEU A 1 227 ? -43.434 34.037 -3.500  1.00 20.94 ? 193 LEU A HD13 1 
ATOM   2987 H HD21 . LEU A 1 227 ? -43.269 34.029 -6.324  1.00 24.27 ? 193 LEU A HD21 1 
ATOM   2988 H HD22 . LEU A 1 227 ? -41.936 33.613 -5.566  1.00 24.27 ? 193 LEU A HD22 1 
ATOM   2989 H HD23 . LEU A 1 227 ? -42.541 32.666 -6.689  1.00 24.27 ? 193 LEU A HD23 1 
ATOM   2990 N N    . ILE A 1 228 ? -40.059 29.755 -4.294  1.00 17.54 ? 194 ILE A N    1 
ATOM   2991 C CA   . ILE A 1 228 ? -39.065 29.166 -3.407  1.00 14.37 ? 194 ILE A CA   1 
ATOM   2992 C C    . ILE A 1 228 ? -38.381 30.315 -2.684  1.00 13.92 ? 194 ILE A C    1 
ATOM   2993 O O    . ILE A 1 228 ? -37.713 31.148 -3.312  1.00 12.99 ? 194 ILE A O    1 
ATOM   2994 C CB   . ILE A 1 228 ? -38.047 28.294 -4.153  1.00 17.43 ? 194 ILE A CB   1 
ATOM   2995 C CG1  . ILE A 1 228 ? -38.765 27.171 -4.907  1.00 15.24 ? 194 ILE A CG1  1 
ATOM   2996 C CG2  . ILE A 1 228 ? -37.033 27.717 -3.163  1.00 17.81 ? 194 ILE A CG2  1 
ATOM   2997 C CD1  . ILE A 1 228 ? -37.851 26.308 -5.758  1.00 18.79 ? 194 ILE A CD1  1 
ATOM   2998 H H    . ILE A 1 228 ? -39.729 30.323 -4.850  1.00 21.07 ? 194 ILE A H    1 
ATOM   2999 H HA   . ILE A 1 228 ? -39.512 28.605 -2.754  1.00 17.27 ? 194 ILE A HA   1 
ATOM   3000 H HB   . ILE A 1 228 ? -37.575 28.843 -4.798  1.00 20.94 ? 194 ILE A HB   1 
ATOM   3001 H HG12 . ILE A 1 228 ? -39.198 26.592 -4.260  1.00 18.31 ? 194 ILE A HG12 1 
ATOM   3002 H HG13 . ILE A 1 228 ? -39.427 27.566 -5.494  1.00 18.31 ? 194 ILE A HG13 1 
ATOM   3003 H HG21 . ILE A 1 228 ? -36.459 27.089 -3.629  1.00 21.40 ? 194 ILE A HG21 1 
ATOM   3004 H HG22 . ILE A 1 228 ? -36.502 28.441 -2.796  1.00 21.40 ? 194 ILE A HG22 1 
ATOM   3005 H HG23 . ILE A 1 228 ? -37.511 27.263 -2.451  1.00 21.40 ? 194 ILE A HG23 1 
ATOM   3006 H HD11 . ILE A 1 228 ? -38.394 25.729 -6.316  1.00 22.58 ? 194 ILE A HD11 1 
ATOM   3007 H HD12 . ILE A 1 228 ? -37.301 26.882 -6.314  1.00 22.58 ? 194 ILE A HD12 1 
ATOM   3008 H HD13 . ILE A 1 228 ? -37.289 25.773 -5.176  1.00 22.58 ? 194 ILE A HD13 1 
ATOM   3009 N N    . VAL A 1 229 ? -38.573 30.377 -1.375  1.00 15.07 ? 195 VAL A N    1 
ATOM   3010 C CA   . VAL A 1 229 ? -37.839 31.278 -0.499  1.00 13.33 ? 195 VAL A CA   1 
ATOM   3011 C C    . VAL A 1 229 ? -36.718 30.480 0.141   1.00 16.60 ? 195 VAL A C    1 
ATOM   3012 O O    . VAL A 1 229 ? -36.898 29.303 0.482   1.00 14.53 ? 195 VAL A O    1 
ATOM   3013 C CB   . VAL A 1 229 ? -38.758 31.893 0.574   1.00 14.35 ? 195 VAL A CB   1 
ATOM   3014 C CG1  . VAL A 1 229 ? -38.060 33.054 1.274   1.00 19.60 ? 195 VAL A CG1  1 
ATOM   3015 C CG2  . VAL A 1 229 ? -40.088 32.334 -0.037  1.00 14.79 ? 195 VAL A CG2  1 
ATOM   3016 H H    . VAL A 1 229 ? -39.143 29.888 -0.955  1.00 18.11 ? 195 VAL A H    1 
ATOM   3017 H HA   . VAL A 1 229 ? -37.464 32.007 -1.018  1.00 16.03 ? 195 VAL A HA   1 
ATOM   3018 H HB   . VAL A 1 229 ? -38.954 31.218 1.242   1.00 17.24 ? 195 VAL A HB   1 
ATOM   3019 H HG11 . VAL A 1 229 ? -38.723 33.589 1.737   1.00 23.55 ? 195 VAL A HG11 1 
ATOM   3020 H HG12 . VAL A 1 229 ? -37.419 32.699 1.910   1.00 23.55 ? 195 VAL A HG12 1 
ATOM   3021 H HG13 . VAL A 1 229 ? -37.603 33.594 0.611   1.00 23.55 ? 195 VAL A HG13 1 
ATOM   3022 H HG21 . VAL A 1 229 ? -40.617 32.776 0.645   1.00 17.78 ? 195 VAL A HG21 1 
ATOM   3023 H HG22 . VAL A 1 229 ? -39.912 32.947 -0.768  1.00 17.78 ? 195 VAL A HG22 1 
ATOM   3024 H HG23 . VAL A 1 229 ? -40.558 31.553 -0.367  1.00 17.78 ? 195 VAL A HG23 1 
ATOM   3025 N N    . TYR A 1 230 ? -35.555 31.103 0.296   1.00 12.77 ? 196 TYR A N    1 
ATOM   3026 C CA   . TYR A 1 230 ? -34.445 30.440 0.959   1.00 14.71 ? 196 TYR A CA   1 
ATOM   3027 C C    . TYR A 1 230 ? -33.745 31.421 1.882   1.00 18.54 ? 196 TYR A C    1 
ATOM   3028 O O    . TYR A 1 230 ? -33.678 32.623 1.612   1.00 15.21 ? 196 TYR A O    1 
ATOM   3029 C CB   . TYR A 1 230 ? -33.471 29.820 -0.055  1.00 15.21 ? 196 TYR A CB   1 
ATOM   3030 C CG   . TYR A 1 230 ? -32.424 30.737 -0.646  1.00 18.03 ? 196 TYR A CG   1 
ATOM   3031 C CD1  . TYR A 1 230 ? -32.696 31.505 -1.771  1.00 15.18 ? 196 TYR A CD1  1 
ATOM   3032 C CD2  . TYR A 1 230 ? -31.147 30.797 -0.107  1.00 19.21 ? 196 TYR A CD2  1 
ATOM   3033 C CE1  . TYR A 1 230 ? -31.731 32.323 -2.326  1.00 13.80 ? 196 TYR A CE1  1 
ATOM   3034 C CE2  . TYR A 1 230 ? -30.178 31.612 -0.654  1.00 24.93 ? 196 TYR A CE2  1 
ATOM   3035 C CZ   . TYR A 1 230 ? -30.474 32.371 -1.763  1.00 14.92 ? 196 TYR A CZ   1 
ATOM   3036 O OH   . TYR A 1 230 ? -29.508 33.180 -2.311  1.00 17.68 ? 196 TYR A OH   1 
ATOM   3037 H H    . TYR A 1 230 ? -35.389 31.902 0.027   1.00 15.35 ? 196 TYR A H    1 
ATOM   3038 H HA   . TYR A 1 230 ? -34.775 29.718 1.517   1.00 17.68 ? 196 TYR A HA   1 
ATOM   3039 H HB2  . TYR A 1 230 ? -32.998 29.098 0.387   1.00 18.28 ? 196 TYR A HB2  1 
ATOM   3040 H HB3  . TYR A 1 230 ? -33.991 29.471 -0.796  1.00 18.28 ? 196 TYR A HB3  1 
ATOM   3041 H HD1  . TYR A 1 230 ? -33.541 31.468 -2.157  1.00 18.24 ? 196 TYR A HD1  1 
ATOM   3042 H HD2  . TYR A 1 230 ? -30.940 30.278 0.637   1.00 23.08 ? 196 TYR A HD2  1 
ATOM   3043 H HE1  . TYR A 1 230 ? -31.928 32.838 -3.075  1.00 16.59 ? 196 TYR A HE1  1 
ATOM   3044 H HE2  . TYR A 1 230 ? -29.329 31.649 -0.275  1.00 29.95 ? 196 TYR A HE2  1 
ATOM   3045 H HH   . TYR A 1 230 ? -29.730 33.407 -3.089  1.00 21.24 ? 196 TYR A HH   1 
ATOM   3046 N N    . ASN A 1 231 ? -33.191 30.817 2.925   1.00 22.29 ? 197 ASN A N    1 
ATOM   3047 C CA   . ASN A 1 231 ? -32.540 31.589 3.948   1.00 13.75 ? 197 ASN A CA   1 
ATOM   3048 C C    . ASN A 1 231 ? -31.066 31.427 3.826   1.00 21.09 ? 197 ASN A C    1 
ATOM   3049 O O    . ASN A 1 231 ? -30.520 30.390 4.133   1.00 21.01 ? 197 ASN A O    1 
ATOM   3050 C CB   . ASN A 1 231 ? -33.038 31.205 5.319   1.00 15.55 ? 197 ASN A CB   1 
ATOM   3051 C CG   . ASN A 1 231 ? -32.462 32.089 6.413   1.00 21.37 ? 197 ASN A CG   1 
ATOM   3052 O OD1  . ASN A 1 231 ? -31.980 33.176 6.142   1.00 22.98 ? 197 ASN A OD1  1 
ATOM   3053 N ND2  . ASN A 1 231 ? -32.511 31.623 7.647   1.00 18.22 ? 197 ASN A ND2  1 
ATOM   3054 H H    . ASN A 1 231 ? -33.169 29.968 3.077   1.00 26.78 ? 197 ASN A H    1 
ATOM   3055 H HA   . ASN A 1 231 ? -32.744 32.536 3.819   1.00 16.53 ? 197 ASN A HA   1 
ATOM   3056 H HB2  . ASN A 1 231 ? -34.004 31.282 5.339   1.00 18.69 ? 197 ASN A HB2  1 
ATOM   3057 H HB3  . ASN A 1 231 ? -32.775 30.289 5.498   1.00 18.69 ? 197 ASN A HB3  1 
ATOM   3058 H HD21 . ASN A 1 231 ? -32.258 32.199 8.400   1.00 21.89 ? 197 ASN A HD21 1 
ATOM   3059 H HD22 . ASN A 1 231 ? -32.802 30.699 7.805   1.00 21.89 ? 197 ASN A HD22 1 
ATOM   3060 N N    . GLY A 1 232 ? -30.457 32.505 3.361   1.00 30.00 ? 198 GLY A N    1 
ATOM   3061 C CA   . GLY A 1 232 ? -29.075 32.496 3.146   1.00 30.00 ? 198 GLY A CA   1 
ATOM   3062 C C    . GLY A 1 232 ? -28.307 33.754 3.284   1.00 30.00 ? 198 GLY A C    1 
ATOM   3063 O O    . GLY A 1 232 ? -27.189 33.634 3.644   1.00 30.00 ? 198 GLY A O    1 
ATOM   3064 N N    . ILE A 1 233 ? -28.855 34.944 3.093   1.00 21.24 ? 199 ILE A N    1 
ATOM   3065 C CA   . ILE A 1 233 ? -27.986 36.125 3.290   1.00 15.06 ? 199 ILE A CA   1 
ATOM   3066 C C    . ILE A 1 233 ? -27.628 36.302 4.767   1.00 18.44 ? 199 ILE A C    1 
ATOM   3067 O O    . ILE A 1 233 ? -28.494 36.551 5.565   1.00 17.22 ? 199 ILE A O    1 
ATOM   3068 C CB   . ILE A 1 233 ? -28.512 37.451 2.731   1.00 20.36 ? 199 ILE A CB   1 
ATOM   3069 C CG1  . ILE A 1 233 ? -28.540 37.430 1.207   1.00 18.89 ? 199 ILE A CG1  1 
ATOM   3070 C CG2  . ILE A 1 233 ? -27.641 38.605 3.187   1.00 14.26 ? 199 ILE A CG2  1 
ATOM   3071 C CD1  . ILE A 1 233 ? -29.458 38.473 0.621   1.00 22.10 ? 199 ILE A CD1  1 
ATOM   3072 H H    . ILE A 1 233 ? -29.667 35.107 2.864   1.00 25.51 ? 199 ILE A H    1 
ATOM   3073 H HA   . ILE A 1 233 ? -27.151 35.957 2.809   1.00 18.10 ? 199 ILE A HA   1 
ATOM   3074 H HB   . ILE A 1 233 ? -29.414 37.589 3.059   1.00 24.46 ? 199 ILE A HB   1 
ATOM   3075 H HG12 . ILE A 1 233 ? -27.642 37.596 0.878   1.00 22.69 ? 199 ILE A HG12 1 
ATOM   3076 H HG13 . ILE A 1 233 ? -28.845 36.558 0.911   1.00 22.69 ? 199 ILE A HG13 1 
ATOM   3077 H HG21 . ILE A 1 233 ? -27.726 39.321 2.553   1.00 17.14 ? 199 ILE A HG21 1 
ATOM   3078 H HG22 . ILE A 1 233 ? -27.936 38.899 4.053   1.00 17.14 ? 199 ILE A HG22 1 
ATOM   3079 H HG23 . ILE A 1 233 ? -26.728 38.309 3.226   1.00 17.14 ? 199 ILE A HG23 1 
ATOM   3080 H HD11 . ILE A 1 233 ? -29.779 38.165 -0.231  1.00 26.54 ? 199 ILE A HD11 1 
ATOM   3081 H HD12 . ILE A 1 233 ? -30.195 38.604 1.222   1.00 26.54 ? 199 ILE A HD12 1 
ATOM   3082 H HD13 . ILE A 1 233 ? -28.971 39.294 0.517   1.00 26.54 ? 199 ILE A HD13 1 
ATOM   3083 N N    . ARG A 1 234 ? -26.349 36.149 5.089   1.00 21.06 ? 200 ARG A N    1 
ATOM   3084 C CA   . ARG A 1 234 ? -25.881 36.293 6.462   1.00 22.39 ? 200 ARG A CA   1 
ATOM   3085 C C    . ARG A 1 234 ? -24.523 36.973 6.416   1.00 20.23 ? 200 ARG A C    1 
ATOM   3086 O O    . ARG A 1 234 ? -23.571 36.418 5.860   1.00 22.29 ? 200 ARG A O    1 
ATOM   3087 C CB   . ARG A 1 234 ? -25.786 34.933 7.161   1.00 21.95 ? 200 ARG A CB   1 
ATOM   3088 C CG   . ARG A 1 234 ? -25.403 34.997 8.639   1.00 25.05 ? 200 ARG A CG   1 
ATOM   3089 C CD   . ARG A 1 234 ? -26.498 35.598 9.517   1.00 16.81 ? 200 ARG A CD   1 
ATOM   3090 N NE   . ARG A 1 234 ? -27.828 35.122 9.157   1.00 19.64 ? 200 ARG A NE   1 
ATOM   3091 C CZ   . ARG A 1 234 ? -28.358 33.976 9.566   1.00 16.73 ? 200 ARG A CZ   1 
ATOM   3092 N NH1  . ARG A 1 234 ? -27.690 33.141 10.344  1.00 22.66 ? 200 ARG A NH1  1 
ATOM   3093 N NH2  . ARG A 1 234 ? -29.590 33.658 9.179   1.00 24.28 ? 200 ARG A NH2  1 
ATOM   3094 H H    . ARG A 1 234 ? -25.722 35.944 4.537   1.00 25.30 ? 200 ARG A H    1 
ATOM   3095 H HA   . ARG A 1 234 ? -26.494 36.847 6.970   1.00 26.90 ? 200 ARG A HA   1 
ATOM   3096 H HB2  . ARG A 1 234 ? -26.649 34.495 7.101   1.00 26.36 ? 200 ARG A HB2  1 
ATOM   3097 H HB3  . ARG A 1 234 ? -25.112 34.401 6.708   1.00 26.36 ? 200 ARG A HB3  1 
ATOM   3098 H HG2  . ARG A 1 234 ? -25.226 34.099 8.957   1.00 30.09 ? 200 ARG A HG2  1 
ATOM   3099 H HG3  . ARG A 1 234 ? -24.610 35.546 8.735   1.00 30.09 ? 200 ARG A HG3  1 
ATOM   3100 H HD2  . ARG A 1 234 ? -26.332 35.355 10.442  1.00 20.20 ? 200 ARG A HD2  1 
ATOM   3101 H HD3  . ARG A 1 234 ? -26.488 36.563 9.421   1.00 20.20 ? 200 ARG A HD3  1 
ATOM   3102 H HE   . ARG A 1 234 ? -28.304 35.620 8.642   1.00 23.59 ? 200 ARG A HE   1 
ATOM   3103 H HH11 . ARG A 1 234 ? -26.892 33.336 10.597  1.00 27.22 ? 200 ARG A HH11 1 
ATOM   3104 H HH12 . ARG A 1 234 ? -28.054 32.404 10.596  1.00 27.22 ? 200 ARG A HH12 1 
ATOM   3105 H HH21 . ARG A 1 234 ? -30.033 34.191 8.671   1.00 29.17 ? 200 ARG A HH21 1 
ATOM   3106 H HH22 . ARG A 1 234 ? -29.944 32.918 9.438   1.00 29.17 ? 200 ARG A HH22 1 
ATOM   3107 N N    . SER A 1 235 ? -24.435 38.172 6.983   1.00 18.49 ? 201 SER A N    1 
ATOM   3108 C CA   . SER A 1 235 ? -23.207 38.959 6.964   1.00 19.96 ? 201 SER A CA   1 
ATOM   3109 C C    . SER A 1 235 ? -22.508 38.815 8.311   1.00 18.44 ? 201 SER A C    1 
ATOM   3110 O O    . SER A 1 235 ? -22.950 39.383 9.314   1.00 18.61 ? 201 SER A O    1 
ATOM   3111 C CB   . SER A 1 235 ? -23.506 40.423 6.650   1.00 16.82 ? 201 SER A CB   1 
ATOM   3112 O OG   . SER A 1 235 ? -23.897 40.576 5.296   1.00 18.98 ? 201 SER A OG   1 
ATOM   3113 H H    . SER A 1 235 ? -25.086 38.557 7.392   1.00 22.21 ? 201 SER A H    1 
ATOM   3114 H HA   . SER A 1 235 ? -22.616 38.612 6.278   1.00 23.98 ? 201 SER A HA   1 
ATOM   3115 H HB2  . SER A 1 235 ? -24.226 40.728 7.223   1.00 20.21 ? 201 SER A HB2  1 
ATOM   3116 H HB3  . SER A 1 235 ? -22.708 40.950 6.810   1.00 20.21 ? 201 SER A HB3  1 
ATOM   3117 H HG   . SER A 1 235 ? -24.597 40.135 5.147   1.00 22.80 ? 201 SER A HG   1 
ATOM   3118 N N    . ILE A 1 236 ? -21.423 38.046 8.327   1.00 22.37 ? 202 ILE A N    1 
ATOM   3119 C CA   . ILE A 1 236 ? -20.577 37.881 9.507   1.00 24.94 ? 202 ILE A CA   1 
ATOM   3120 C C    . ILE A 1 236 ? -19.144 38.175 9.073   1.00 27.27 ? 202 ILE A C    1 
ATOM   3121 O O    . ILE A 1 236 ? -18.722 37.702 8.008   1.00 24.50 ? 202 ILE A O    1 
ATOM   3122 C CB   . ILE A 1 236 ? -20.709 36.470 10.102  1.00 23.79 ? 202 ILE A CB   1 
ATOM   3123 C CG1  . ILE A 1 236 ? -22.149 36.216 10.554  1.00 24.04 ? 202 ILE A CG1  1 
ATOM   3124 C CG2  . ILE A 1 236 ? -19.740 36.287 11.265  1.00 28.90 ? 202 ILE A CG2  1 
ATOM   3125 C CD1  . ILE A 1 236 ? -22.463 34.757 10.822  1.00 31.44 ? 202 ILE A CD1  1 
ATOM   3126 H H    . ILE A 1 236 ? -21.148 37.596 7.648   1.00 26.88 ? 202 ILE A H    1 
ATOM   3127 H HA   . ILE A 1 236 ? -20.839 38.509 10.198  1.00 29.96 ? 202 ILE A HA   1 
ATOM   3128 H HB   . ILE A 1 236 ? -20.485 35.825 9.413   1.00 28.57 ? 202 ILE A HB   1 
ATOM   3129 H HG12 . ILE A 1 236 ? -22.309 36.708 11.374  1.00 28.88 ? 202 ILE A HG12 1 
ATOM   3130 H HG13 . ILE A 1 236 ? -22.752 36.525 9.859   1.00 28.88 ? 202 ILE A HG13 1 
ATOM   3131 H HG21 . ILE A 1 236 ? -19.958 35.465 11.731  1.00 34.71 ? 202 ILE A HG21 1 
ATOM   3132 H HG22 . ILE A 1 236 ? -18.835 36.242 10.918  1.00 34.71 ? 202 ILE A HG22 1 
ATOM   3133 H HG23 . ILE A 1 236 ? -19.825 37.042 11.868  1.00 34.71 ? 202 ILE A HG23 1 
ATOM   3134 H HD11 . ILE A 1 236 ? -23.402 34.672 11.050  1.00 37.76 ? 202 ILE A HD11 1 
ATOM   3135 H HD12 . ILE A 1 236 ? -22.269 34.241 10.024  1.00 37.76 ? 202 ILE A HD12 1 
ATOM   3136 H HD13 . ILE A 1 236 ? -21.914 34.446 11.558  1.00 37.76 ? 202 ILE A HD13 1 
ATOM   3137 N N    . PRO A 1 237 ? -18.372 38.948 9.837   1.00 28.70 ? 203 PRO A N    1 
ATOM   3138 C CA   . PRO A 1 237 ? -17.014 39.296 9.396   1.00 32.99 ? 203 PRO A CA   1 
ATOM   3139 C C    . PRO A 1 237 ? -16.223 38.079 8.939   1.00 33.24 ? 203 PRO A C    1 
ATOM   3140 O O    . PRO A 1 237 ? -16.096 37.087 9.661   1.00 30.64 ? 203 PRO A O    1 
ATOM   3141 C CB   . PRO A 1 237 ? -16.394 39.936 10.642  1.00 33.57 ? 203 PRO A CB   1 
ATOM   3142 C CG   . PRO A 1 237 ? -17.543 40.491 11.402  1.00 35.17 ? 203 PRO A CG   1 
ATOM   3143 C CD   . PRO A 1 237 ? -18.762 39.678 11.058  1.00 26.25 ? 203 PRO A CD   1 
ATOM   3144 H HA   . PRO A 1 237 ? -17.054 39.941 8.673   1.00 39.62 ? 203 PRO A HA   1 
ATOM   3145 H HB2  . PRO A 1 237 ? -15.927 39.262 11.161  1.00 40.31 ? 203 PRO A HB2  1 
ATOM   3146 H HB3  . PRO A 1 237 ? -15.779 40.638 10.380  1.00 40.31 ? 203 PRO A HB3  1 
ATOM   3147 H HG2  . PRO A 1 237 ? -17.355 40.430 12.352  1.00 42.23 ? 203 PRO A HG2  1 
ATOM   3148 H HG3  . PRO A 1 237 ? -17.674 41.418 11.149  1.00 42.23 ? 203 PRO A HG3  1 
ATOM   3149 H HD2  . PRO A 1 237 ? -18.974 39.059 11.774  1.00 31.53 ? 203 PRO A HD2  1 
ATOM   3150 H HD3  . PRO A 1 237 ? -19.521 40.257 10.884  1.00 31.53 ? 203 PRO A HD3  1 
ATOM   3151 N N    . ASN A 1 238 ? -15.696 38.159 7.718   1.00 32.57 ? 204 ASN A N    1 
ATOM   3152 C CA   . ASN A 1 238 ? -14.847 37.138 7.112   1.00 40.04 ? 204 ASN A CA   1 
ATOM   3153 C C    . ASN A 1 238 ? -15.586 35.837 6.830   1.00 37.21 ? 204 ASN A C    1 
ATOM   3154 O O    . ASN A 1 238 ? -14.946 34.836 6.479   1.00 40.95 ? 204 ASN A O    1 
ATOM   3155 C CB   . ASN A 1 238 ? -13.623 36.841 7.986   1.00 49.41 ? 204 ASN A CB   1 
ATOM   3156 C CG   . ASN A 1 238 ? -12.920 38.101 8.449   1.00 45.55 ? 204 ASN A CG   1 
ATOM   3157 O OD1  . ASN A 1 238 ? -12.979 39.138 7.788   1.00 44.42 ? 204 ASN A OD1  1 
ATOM   3158 N ND2  . ASN A 1 238 ? -12.252 38.017 9.593   1.00 54.44 ? 204 ASN A ND2  1 
ATOM   3159 H H    . ASN A 1 238 ? -15.824 38.831 7.197   1.00 39.11 ? 204 ASN A H    1 
ATOM   3160 H HA   . ASN A 1 238 ? -14.541 37.481 6.258   1.00 48.07 ? 204 ASN A HA   1 
ATOM   3161 H HB2  . ASN A 1 238 ? -13.907 36.349 8.772   1.00 59.32 ? 204 ASN A HB2  1 
ATOM   3162 H HB3  . ASN A 1 238 ? -12.990 36.314 7.475   1.00 59.32 ? 204 ASN A HB3  1 
ATOM   3163 H HD21 . ASN A 1 238 ? -11.836 38.705 9.899   1.00 65.36 ? 204 ASN A HD21 1 
ATOM   3164 H HD22 . ASN A 1 238 ? -12.235 37.276 10.028  1.00 65.36 ? 204 ASN A HD22 1 
ATOM   3165 N N    . ARG A 1 239 ? -16.910 35.814 6.968   1.00 27.26 ? 205 ARG A N    1 
ATOM   3166 C CA   . ARG A 1 239 ? -17.700 34.612 6.723   1.00 28.44 ? 205 ARG A CA   1 
ATOM   3167 C C    . ARG A 1 239 ? -19.031 34.982 6.085   1.00 27.74 ? 205 ARG A C    1 
ATOM   3168 O O    . ARG A 1 239 ? -20.067 34.370 6.364   1.00 31.58 ? 205 ARG A O    1 
ATOM   3169 C CB   . ARG A 1 239 ? -17.922 33.826 8.015   1.00 30.19 ? 205 ARG A CB   1 
ATOM   3170 H H    . ARG A 1 239 ? -17.379 36.494 7.206   1.00 32.73 ? 205 ARG A H    1 
ATOM   3171 H HA   . ARG A 1 239 ? -17.218 34.043 6.103   1.00 34.15 ? 205 ARG A HA   1 
ATOM   3172 N N    . ASN A 1 240 ? -19.016 35.986 5.213   1.00 25.92 ? 206 ASN A N    1 
ATOM   3173 C CA   . ASN A 1 240 ? -20.250 36.482 4.623   1.00 28.99 ? 206 ASN A CA   1 
ATOM   3174 C C    . ASN A 1 240 ? -20.863 35.448 3.690   1.00 30.61 ? 206 ASN A C    1 
ATOM   3175 O O    . ASN A 1 240 ? -20.160 34.753 2.951   1.00 28.43 ? 206 ASN A O    1 
ATOM   3176 C CB   . ASN A 1 240 ? -19.990 37.775 3.852   1.00 28.27 ? 206 ASN A CB   1 
ATOM   3177 C CG   . ASN A 1 240 ? -19.713 38.952 4.761   1.00 24.92 ? 206 ASN A CG   1 
ATOM   3178 O OD1  . ASN A 1 240 ? -20.138 38.975 5.916   1.00 24.52 ? 206 ASN A OD1  1 
ATOM   3179 N ND2  . ASN A 1 240 ? -19.004 39.944 4.240   1.00 23.10 ? 206 ASN A ND2  1 
ATOM   3180 H H    . ASN A 1 240 ? -18.307 36.394 4.949   1.00 31.13 ? 206 ASN A H    1 
ATOM   3181 H HA   . ASN A 1 240 ? -20.884 36.667 5.334   1.00 34.82 ? 206 ASN A HA   1 
ATOM   3182 H HB2  . ASN A 1 240 ? -19.219 37.651 3.277   1.00 33.95 ? 206 ASN A HB2  1 
ATOM   3183 H HB3  . ASN A 1 240 ? -20.772 37.987 3.317   1.00 33.95 ? 206 ASN A HB3  1 
ATOM   3184 H HD21 . ASN A 1 240 ? -18.819 40.636 4.715   1.00 27.75 ? 206 ASN A HD21 1 
ATOM   3185 H HD22 . ASN A 1 240 ? -18.729 39.894 3.426   1.00 27.75 ? 206 ASN A HD22 1 
ATOM   3186 N N    . VAL A 1 241 ? -22.188 35.354 3.729   1.00 29.42 ? 207 VAL A N    1 
ATOM   3187 C CA   . VAL A 1 241 ? -22.961 34.557 2.788   1.00 25.90 ? 207 VAL A CA   1 
ATOM   3188 C C    . VAL A 1 241 ? -23.947 35.494 2.111   1.00 24.89 ? 207 VAL A C    1 
ATOM   3189 O O    . VAL A 1 241 ? -24.675 36.229 2.788   1.00 22.52 ? 207 VAL A O    1 
ATOM   3190 C CB   . VAL A 1 241 ? -23.695 33.397 3.486   1.00 30.08 ? 207 VAL A CB   1 
ATOM   3191 C CG1  . VAL A 1 241 ? -24.656 32.711 2.520   1.00 26.43 ? 207 VAL A CG1  1 
ATOM   3192 C CG2  . VAL A 1 241 ? -22.695 32.409 4.056   1.00 31.86 ? 207 VAL A CG2  1 
ATOM   3193 H H    . VAL A 1 241 ? -22.675 35.757 4.312   1.00 35.33 ? 207 VAL A H    1 
ATOM   3194 H HA   . VAL A 1 241 ? -22.375 34.173 2.118   1.00 31.10 ? 207 VAL A HA   1 
ATOM   3195 H HB   . VAL A 1 241 ? -24.219 33.750 4.222   1.00 36.12 ? 207 VAL A HB   1 
ATOM   3196 H HG11 . VAL A 1 241 ? -24.980 31.892 2.925   1.00 31.74 ? 207 VAL A HG11 1 
ATOM   3197 H HG12 . VAL A 1 241 ? -25.400 33.307 2.338   1.00 31.74 ? 207 VAL A HG12 1 
ATOM   3198 H HG13 . VAL A 1 241 ? -24.185 32.509 1.696   1.00 31.74 ? 207 VAL A HG13 1 
ATOM   3199 H HG21 . VAL A 1 241 ? -23.156 31.806 4.659   1.00 38.26 ? 207 VAL A HG21 1 
ATOM   3200 H HG22 . VAL A 1 241 ? -22.296 31.908 3.327   1.00 38.26 ? 207 VAL A HG22 1 
ATOM   3201 H HG23 . VAL A 1 241 ? -22.008 32.897 4.537   1.00 38.26 ? 207 VAL A HG23 1 
ATOM   3202 N N    . GLY A 1 242 ? -23.954 35.483 0.781   1.00 19.83 ? 208 GLY A N    1 
ATOM   3203 C CA   . GLY A 1 242 ? -24.824 36.356 0.023   1.00 20.04 ? 208 GLY A CA   1 
ATOM   3204 C C    . GLY A 1 242 ? -25.960 35.614 -0.645  1.00 21.93 ? 208 GLY A C    1 
ATOM   3205 O O    . GLY A 1 242 ? -26.397 34.561 -0.170  1.00 24.52 ? 208 GLY A O    1 
ATOM   3206 H H    . GLY A 1 242 ? -23.459 34.973 0.297   1.00 23.83 ? 208 GLY A H    1 
ATOM   3207 H HA2  . GLY A 1 242 ? -25.203 37.023 0.617   1.00 24.08 ? 208 GLY A HA2  1 
ATOM   3208 H HA3  . GLY A 1 242 ? -24.306 36.804 -0.665  1.00 24.08 ? 208 GLY A HA3  1 
ATOM   3209 N N    . ASN A 1 243 ? -26.450 36.166 -1.755  1.00 21.51 ? 209 ASN A N    1 
ATOM   3210 C CA   . ASN A 1 243 ? -27.497 35.532 -2.554  1.00 20.57 ? 209 ASN A CA   1 
ATOM   3211 C C    . ASN A 1 243 ? -26.837 34.506 -3.478  1.00 20.96 ? 209 ASN A C    1 
ATOM   3212 O O    . ASN A 1 243 ? -26.718 34.681 -4.692  1.00 19.08 ? 209 ASN A O    1 
ATOM   3213 C CB   . ASN A 1 243 ? -28.278 36.590 -3.323  1.00 22.60 ? 209 ASN A CB   1 
ATOM   3214 C CG   . ASN A 1 243 ? -29.247 35.994 -4.326  1.00 18.44 ? 209 ASN A CG   1 
ATOM   3215 O OD1  . ASN A 1 243 ? -29.834 34.938 -4.093  1.00 21.80 ? 209 ASN A OD1  1 
ATOM   3216 N ND2  . ASN A 1 243 ? -29.425 36.680 -5.448  1.00 21.79 ? 209 ASN A ND2  1 
ATOM   3217 H H    . ASN A 1 243 ? -26.186 36.921 -2.071  1.00 25.84 ? 209 ASN A H    1 
ATOM   3218 H HA   . ASN A 1 243 ? -28.123 35.065 -1.979  1.00 24.71 ? 209 ASN A HA   1 
ATOM   3219 H HB2  . ASN A 1 243 ? -28.789 37.123 -2.694  1.00 27.14 ? 209 ASN A HB2  1 
ATOM   3220 H HB3  . ASN A 1 243 ? -27.655 37.153 -3.807  1.00 27.14 ? 209 ASN A HB3  1 
ATOM   3221 H HD21 . ASN A 1 243 ? -29.964 36.385 -6.050  1.00 26.17 ? 209 ASN A HD21 1 
ATOM   3222 H HD22 . ASN A 1 243 ? -29.002 37.418 -5.573  1.00 26.17 ? 209 ASN A HD22 1 
ATOM   3223 N N    . ASP A 1 244 ? -26.391 33.412 -2.865  1.00 19.07 ? 210 ASP A N    1 
ATOM   3224 C CA   . ASP A 1 244 ? -25.517 32.448 -3.522  1.00 24.57 ? 210 ASP A CA   1 
ATOM   3225 C C    . ASP A 1 244 ? -26.261 31.276 -4.149  1.00 24.20 ? 210 ASP A C    1 
ATOM   3226 O O    . ASP A 1 244 ? -25.613 30.356 -4.658  1.00 26.41 ? 210 ASP A O    1 
ATOM   3227 C CB   . ASP A 1 244 ? -24.485 31.921 -2.520  1.00 26.38 ? 210 ASP A CB   1 
ATOM   3228 C CG   . ASP A 1 244 ? -23.610 33.023 -1.952  1.00 24.84 ? 210 ASP A CG   1 
ATOM   3229 O OD1  . ASP A 1 244 ? -23.349 34.011 -2.672  1.00 23.62 ? 210 ASP A OD1  1 
ATOM   3230 O OD2  . ASP A 1 244 ? -23.186 32.903 -0.784  1.00 28.29 ? 210 ASP A OD2  1 
ATOM   3231 H H    . ASP A 1 244 ? -26.585 33.203 -2.053  1.00 22.91 ? 210 ASP A H    1 
ATOM   3232 H HA   . ASP A 1 244 ? -25.047 32.904 -4.238  1.00 29.51 ? 210 ASP A HA   1 
ATOM   3233 H HB2  . ASP A 1 244 ? -24.948 31.495 -1.782  1.00 31.68 ? 210 ASP A HB2  1 
ATOM   3234 H HB3  . ASP A 1 244 ? -23.910 31.280 -2.965  1.00 31.68 ? 210 ASP A HB3  1 
ATOM   3235 N N    . PHE A 1 245 ? -27.592 31.278 -4.129  1.00 21.87 ? 211 PHE A N    1 
ATOM   3236 C CA   . PHE A 1 245 ? -28.396 30.256 -4.802  1.00 23.33 ? 211 PHE A CA   1 
ATOM   3237 C C    . PHE A 1 245 ? -29.508 30.930 -5.600  1.00 21.43 ? 211 PHE A C    1 
ATOM   3238 O O    . PHE A 1 245 ? -30.696 30.716 -5.344  1.00 17.32 ? 211 PHE A O    1 
ATOM   3239 C CB   . PHE A 1 245 ? -28.965 29.263 -3.790  1.00 22.17 ? 211 PHE A CB   1 
ATOM   3240 C CG   . PHE A 1 245 ? -27.922 28.622 -2.915  1.00 22.40 ? 211 PHE A CG   1 
ATOM   3241 C CD1  . PHE A 1 245 ? -27.503 29.239 -1.748  1.00 21.70 ? 211 PHE A CD1  1 
ATOM   3242 C CD2  . PHE A 1 245 ? -27.360 27.405 -3.262  1.00 27.27 ? 211 PHE A CD2  1 
ATOM   3243 C CE1  . PHE A 1 245 ? -26.543 28.653 -0.942  1.00 24.10 ? 211 PHE A CE1  1 
ATOM   3244 C CE2  . PHE A 1 245 ? -26.398 26.813 -2.459  1.00 24.98 ? 211 PHE A CE2  1 
ATOM   3245 C CZ   . PHE A 1 245 ? -25.990 27.439 -1.299  1.00 23.98 ? 211 PHE A CZ   1 
ATOM   3246 H H    . PHE A 1 245 ? -28.063 31.874 -3.725  1.00 26.27 ? 211 PHE A H    1 
ATOM   3247 H HA   . PHE A 1 245 ? -27.834 29.763 -5.420  1.00 28.02 ? 211 PHE A HA   1 
ATOM   3248 H HB2  . PHE A 1 245 ? -29.589 29.730 -3.212  1.00 26.64 ? 211 PHE A HB2  1 
ATOM   3249 H HB3  . PHE A 1 245 ? -29.423 28.556 -4.270  1.00 26.64 ? 211 PHE A HB3  1 
ATOM   3250 H HD1  . PHE A 1 245 ? -27.871 30.056 -1.502  1.00 26.07 ? 211 PHE A HD1  1 
ATOM   3251 H HD2  . PHE A 1 245 ? -27.631 26.980 -4.044  1.00 32.75 ? 211 PHE A HD2  1 
ATOM   3252 H HE1  . PHE A 1 245 ? -26.270 29.077 -0.161  1.00 28.95 ? 211 PHE A HE1  1 
ATOM   3253 H HE2  . PHE A 1 245 ? -26.028 25.995 -2.702  1.00 30.00 ? 211 PHE A HE2  1 
ATOM   3254 H HZ   . PHE A 1 245 ? -25.344 27.044 -0.759  1.00 28.80 ? 211 PHE A HZ   1 
ATOM   3255 N N    . PRO A 1 246 ? -29.149 31.751 -6.596  1.00 19.54 ? 212 PRO A N    1 
ATOM   3256 C CA   . PRO A 1 246 ? -30.160 32.563 -7.288  1.00 24.97 ? 212 PRO A CA   1 
ATOM   3257 C C    . PRO A 1 246 ? -30.946 31.843 -8.375  1.00 19.71 ? 212 PRO A C    1 
ATOM   3258 O O    . PRO A 1 246 ? -32.089 32.218 -8.650  1.00 18.35 ? 212 PRO A O    1 
ATOM   3259 C CB   . PRO A 1 246 ? -29.322 33.697 -7.895  1.00 23.88 ? 212 PRO A CB   1 
ATOM   3260 C CG   . PRO A 1 246 ? -27.996 33.064 -8.149  1.00 20.96 ? 212 PRO A CG   1 
ATOM   3261 C CD   . PRO A 1 246 ? -27.779 32.125 -6.993  1.00 22.52 ? 212 PRO A CD   1 
ATOM   3262 H HA   . PRO A 1 246 ? -30.791 32.895 -6.630  1.00 29.99 ? 212 PRO A HA   1 
ATOM   3263 H HB2  . PRO A 1 246 ? -29.727 34.007 -8.720  1.00 28.69 ? 212 PRO A HB2  1 
ATOM   3264 H HB3  . PRO A 1 246 ? -29.246 34.431 -7.266  1.00 28.69 ? 212 PRO A HB3  1 
ATOM   3265 H HG2  . PRO A 1 246 ? -28.017 32.580 -8.989  1.00 25.18 ? 212 PRO A HG2  1 
ATOM   3266 H HG3  . PRO A 1 246 ? -27.306 33.745 -8.176  1.00 25.18 ? 212 PRO A HG3  1 
ATOM   3267 H HD2  . PRO A 1 246 ? -27.276 31.344 -7.273  1.00 27.05 ? 212 PRO A HD2  1 
ATOM   3268 H HD3  . PRO A 1 246 ? -27.319 32.573 -6.266  1.00 27.05 ? 212 PRO A HD3  1 
ATOM   3269 N N    . GLU A 1 247 ? -30.359 30.819 -9.000  1.00 26.37 ? 213 GLU A N    1 
ATOM   3270 C CA   . GLU A 1 247 ? -30.901 30.302 -10.256 1.00 25.23 ? 213 GLU A CA   1 
ATOM   3271 C C    . GLU A 1 247 ? -32.388 29.973 -10.146 1.00 24.71 ? 213 GLU A C    1 
ATOM   3272 O O    . GLU A 1 247 ? -33.216 30.525 -10.880 1.00 32.54 ? 213 GLU A O    1 
ATOM   3273 C CB   . GLU A 1 247 ? -30.120 29.065 -10.705 1.00 23.69 ? 213 GLU A CB   1 
ATOM   3274 C CG   . GLU A 1 247 ? -30.787 28.340 -11.868 1.00 28.98 ? 213 GLU A CG   1 
ATOM   3275 C CD   . GLU A 1 247 ? -29.806 27.615 -12.767 1.00 32.37 ? 213 GLU A CD   1 
ATOM   3276 O OE1  . GLU A 1 247 ? -28.782 27.113 -12.258 1.00 29.47 ? 213 GLU A OE1  1 
ATOM   3277 O OE2  . GLU A 1 247 ? -30.066 27.546 -13.988 1.00 32.74 ? 213 GLU A OE2  1 
ATOM   3278 H H    . GLU A 1 247 ? -29.655 30.411 -8.721  1.00 31.67 ? 213 GLU A H    1 
ATOM   3279 H HA   . GLU A 1 247 ? -30.796 30.995 -10.927 1.00 30.30 ? 213 GLU A HA   1 
ATOM   3280 H HB2  . GLU A 1 247 ? -29.233 29.337 -10.989 1.00 28.45 ? 213 GLU A HB2  1 
ATOM   3281 H HB3  . GLU A 1 247 ? -30.055 28.445 -9.962  1.00 28.45 ? 213 GLU A HB3  1 
ATOM   3282 H HG2  . GLU A 1 247 ? -31.407 27.683 -11.514 1.00 34.80 ? 213 GLU A HG2  1 
ATOM   3283 H HG3  . GLU A 1 247 ? -31.263 28.988 -12.410 1.00 34.80 ? 213 GLU A HG3  1 
ATOM   3284 N N    . HIS A 1 248 ? -32.747 29.066 -9.239  1.00 18.23 ? 214 HIS A N    1 
ATOM   3285 C CA   . HIS A 1 248 ? -34.100 28.530 -9.176  1.00 19.44 ? 214 HIS A CA   1 
ATOM   3286 C C    . HIS A 1 248 ? -34.949 29.153 -8.077  1.00 23.02 ? 214 HIS A C    1 
ATOM   3287 O O    . HIS A 1 248 ? -36.092 28.727 -7.885  1.00 15.58 ? 214 HIS A O    1 
ATOM   3288 C CB   . HIS A 1 248 ? -34.057 27.010 -8.974  1.00 22.73 ? 214 HIS A CB   1 
ATOM   3289 C CG   . HIS A 1 248 ? -33.354 26.270 -10.070 1.00 25.62 ? 214 HIS A CG   1 
ATOM   3290 N ND1  . HIS A 1 248 ? -33.841 26.210 -11.358 1.00 28.44 ? 214 HIS A ND1  1 
ATOM   3291 C CD2  . HIS A 1 248 ? -32.207 25.551 -10.067 1.00 26.94 ? 214 HIS A CD2  1 
ATOM   3292 C CE1  . HIS A 1 248 ? -33.020 25.491 -12.103 1.00 25.67 ? 214 HIS A CE1  1 
ATOM   3293 N NE2  . HIS A 1 248 ? -32.021 25.080 -11.344 1.00 25.70 ? 214 HIS A NE2  1 
ATOM   3294 H H    . HIS A 1 248 ? -32.216 28.743 -8.644  1.00 21.90 ? 214 HIS A H    1 
ATOM   3295 H HA   . HIS A 1 248 ? -34.534 28.715 -10.024 1.00 23.35 ? 214 HIS A HA   1 
ATOM   3296 H HB2  . HIS A 1 248 ? -33.592 26.820 -8.144  1.00 27.31 ? 214 HIS A HB2  1 
ATOM   3297 H HB3  . HIS A 1 248 ? -34.967 26.676 -8.928  1.00 27.31 ? 214 HIS A HB3  1 
ATOM   3298 H HD2  . HIS A 1 248 ? -31.649 25.404 -9.337  1.00 32.36 ? 214 HIS A HD2  1 
ATOM   3299 H HE1  . HIS A 1 248 ? -33.129 25.305 -13.008 1.00 30.83 ? 214 HIS A HE1  1 
ATOM   3300 H HE2  . HIS A 1 248 ? -31.360 24.596 -11.606 1.00 30.87 ? 214 HIS A HE2  1 
ATOM   3301 N N    . THR A 1 249 ? -34.432 30.146 -7.360  1.00 18.34 ? 215 THR A N    1 
ATOM   3302 C CA   . THR A 1 249 ? -35.115 30.721 -6.212  1.00 20.92 ? 215 THR A CA   1 
ATOM   3303 C C    . THR A 1 249 ? -35.690 32.090 -6.558  1.00 18.86 ? 215 THR A C    1 
ATOM   3304 O O    . THR A 1 249 ? -35.226 32.774 -7.474  1.00 18.24 ? 215 THR A O    1 
ATOM   3305 C CB   . THR A 1 249 ? -34.163 30.844 -5.019  1.00 16.11 ? 215 THR A CB   1 
ATOM   3306 O OG1  . THR A 1 249 ? -33.063 31.689 -5.372  1.00 15.30 ? 215 THR A OG1  1 
ATOM   3307 C CG2  . THR A 1 249 ? -33.638 29.473 -4.613  1.00 17.00 ? 215 THR A CG2  1 
ATOM   3308 H H    . THR A 1 249 ? -33.670 30.508 -7.524  1.00 22.04 ? 215 THR A H    1 
ATOM   3309 H HA   . THR A 1 249 ? -35.853 30.144 -5.959  1.00 25.13 ? 215 THR A HA   1 
ATOM   3310 H HB   . THR A 1 249 ? -34.635 31.226 -4.262  1.00 19.36 ? 215 THR A HB   1 
ATOM   3311 H HG1  . THR A 1 249 ? -32.599 31.856 -4.692  1.00 18.39 ? 215 THR A HG1  1 
ATOM   3312 H HG21 . THR A 1 249 ? -33.088 29.551 -3.818  1.00 20.43 ? 215 THR A HG21 1 
ATOM   3313 H HG22 . THR A 1 249 ? -34.379 28.876 -4.427  1.00 20.43 ? 215 THR A HG22 1 
ATOM   3314 H HG23 . THR A 1 249 ? -33.103 29.098 -5.330  1.00 20.43 ? 215 THR A HG23 1 
ATOM   3315 N N    . ASP A 1 250 ? -36.714 32.481 -5.799  1.00 16.08 ? 216 ASP A N    1 
ATOM   3316 C CA   . ASP A 1 250 ? -37.417 33.739 -6.008  1.00 17.14 ? 216 ASP A CA   1 
ATOM   3317 C C    . ASP A 1 250 ? -37.207 34.746 -4.893  1.00 17.82 ? 216 ASP A C    1 
ATOM   3318 O O    . ASP A 1 250 ? -37.292 35.950 -5.141  1.00 16.69 ? 216 ASP A O    1 
ATOM   3319 C CB   . ASP A 1 250 ? -38.923 33.488 -6.145  1.00 17.31 ? 216 ASP A CB   1 
ATOM   3320 C CG   . ASP A 1 250 ? -39.244 32.451 -7.189  1.00 16.59 ? 216 ASP A CG   1 
ATOM   3321 O OD1  . ASP A 1 250 ? -39.009 32.720 -8.387  1.00 18.77 ? 216 ASP A OD1  1 
ATOM   3322 O OD2  . ASP A 1 250 ? -39.724 31.364 -6.811  1.00 13.93 ? 216 ASP A OD2  1 
ATOM   3323 H H    . ASP A 1 250 ? -37.026 32.021 -5.142  1.00 19.33 ? 216 ASP A H    1 
ATOM   3324 H HA   . ASP A 1 250 ? -37.098 34.135 -6.834  1.00 20.60 ? 216 ASP A HA   1 
ATOM   3325 H HB2  . ASP A 1 250 ? -39.271 33.177 -5.295  1.00 20.80 ? 216 ASP A HB2  1 
ATOM   3326 H HB3  . ASP A 1 250 ? -39.360 34.316 -6.399  1.00 20.80 ? 216 ASP A HB3  1 
ATOM   3327 N N    . ALA A 1 251 ? -36.940 34.284 -3.676  1.00 14.18 ? 217 ALA A N    1 
ATOM   3328 C CA   . ALA A 1 251 ? -36.866 35.155 -2.516  1.00 15.47 ? 217 ALA A CA   1 
ATOM   3329 C C    . ALA A 1 251 ? -35.718 34.716 -1.624  1.00 15.50 ? 217 ALA A C    1 
ATOM   3330 O O    . ALA A 1 251 ? -35.500 33.517 -1.420  1.00 13.37 ? 217 ALA A O    1 
ATOM   3331 C CB   . ALA A 1 251 ? -38.179 35.141 -1.726  1.00 12.80 ? 217 ALA A CB   1 
ATOM   3332 H H    . ALA A 1 251 ? -36.797 33.455 -3.496  1.00 17.04 ? 217 ALA A H    1 
ATOM   3333 H HA   . ALA A 1 251 ? -36.691 36.065 -2.804  1.00 18.60 ? 217 ALA A HA   1 
ATOM   3334 H HB1  . ALA A 1 251 ? -38.137 35.818 -1.032  1.00 15.38 ? 217 ALA A HB1  1 
ATOM   3335 H HB2  . ALA A 1 251 ? -38.913 35.331 -2.330  1.00 15.38 ? 217 ALA A HB2  1 
ATOM   3336 H HB3  . ALA A 1 251 ? -38.298 34.265 -1.326  1.00 15.38 ? 217 ALA A HB3  1 
ATOM   3337 N N    . VAL A 1 252 ? -34.989 35.695 -1.098  1.00 12.65 ? 218 VAL A N    1 
ATOM   3338 C CA   . VAL A 1 252 ? -33.856 35.458 -0.215  1.00 15.66 ? 218 VAL A CA   1 
ATOM   3339 C C    . VAL A 1 252 ? -34.097 36.211 1.086   1.00 19.34 ? 218 VAL A C    1 
ATOM   3340 O O    . VAL A 1 252 ? -34.564 37.356 1.077   1.00 19.47 ? 218 VAL A O    1 
ATOM   3341 C CB   . VAL A 1 252 ? -32.527 35.893 -0.867  1.00 14.66 ? 218 VAL A CB   1 
ATOM   3342 C CG1  . VAL A 1 252 ? -32.515 37.394 -1.105  1.00 16.41 ? 218 VAL A CG1  1 
ATOM   3343 C CG2  . VAL A 1 252 ? -31.348 35.463 -0.003  1.00 21.91 ? 218 VAL A CG2  1 
ATOM   3344 H H    . VAL A 1 252 ? -35.138 36.530 -1.243  1.00 15.21 ? 218 VAL A H    1 
ATOM   3345 H HA   . VAL A 1 252 ? -33.794 34.512 -0.013  1.00 18.82 ? 218 VAL A HA   1 
ATOM   3346 H HB   . VAL A 1 252 ? -32.439 35.458 -1.729  1.00 17.62 ? 218 VAL A HB   1 
ATOM   3347 H HG11 . VAL A 1 252 ? -31.820 37.606 -1.748  1.00 19.72 ? 218 VAL A HG11 1 
ATOM   3348 H HG12 . VAL A 1 252 ? -33.380 37.666 -1.451  1.00 19.72 ? 218 VAL A HG12 1 
ATOM   3349 H HG13 . VAL A 1 252 ? -32.338 37.846 -0.265  1.00 19.72 ? 218 VAL A HG13 1 
ATOM   3350 H HG21 . VAL A 1 252 ? -30.531 35.546 -0.519  1.00 26.32 ? 218 VAL A HG21 1 
ATOM   3351 H HG22 . VAL A 1 252 ? -31.305 36.035 0.779   1.00 26.32 ? 218 VAL A HG22 1 
ATOM   3352 H HG23 . VAL A 1 252 ? -31.476 34.540 0.269   1.00 26.32 ? 218 VAL A HG23 1 
ATOM   3353 N N    A MET A 1 253 ? -33.798 35.563 2.207   0.63 17.63 ? 219 MET A N    1 
ATOM   3354 N N    B MET A 1 253 ? -33.744 35.573 2.196   0.37 17.54 ? 219 MET A N    1 
ATOM   3355 C CA   A MET A 1 253 ? -34.053 36.133 3.522   0.63 17.35 ? 219 MET A CA   1 
ATOM   3356 C CA   B MET A 1 253 ? -34.003 36.095 3.527   0.37 17.51 ? 219 MET A CA   1 
ATOM   3357 C C    A MET A 1 253 ? -32.774 36.719 4.107   0.63 17.82 ? 219 MET A C    1 
ATOM   3358 C C    B MET A 1 253 ? -32.744 36.720 4.112   0.37 17.78 ? 219 MET A C    1 
ATOM   3359 O O    A MET A 1 253 ? -31.693 36.137 3.976   0.63 17.49 ? 219 MET A O    1 
ATOM   3360 O O    B MET A 1 253 ? -31.649 36.164 3.990   0.37 17.48 ? 219 MET A O    1 
ATOM   3361 C CB   A MET A 1 253 ? -34.622 35.080 4.479   0.63 18.62 ? 219 MET A CB   1 
ATOM   3362 C CB   B MET A 1 253 ? -34.497 34.980 4.449   0.37 18.65 ? 219 MET A CB   1 
ATOM   3363 C CG   A MET A 1 253 ? -34.428 35.420 5.955   0.63 23.04 ? 219 MET A CG   1 
ATOM   3364 C CG   B MET A 1 253 ? -35.527 35.441 5.449   0.37 21.67 ? 219 MET A CG   1 
ATOM   3365 S SD   A MET A 1 253 ? -35.523 34.504 7.058   0.63 23.43 ? 219 MET A SD   1 
ATOM   3366 S SD   B MET A 1 253 ? -37.180 35.288 4.765   0.37 21.24 ? 219 MET A SD   1 
ATOM   3367 C CE   A MET A 1 253 ? -36.764 35.744 7.424   0.63 21.96 ? 219 MET A CE   1 
ATOM   3368 C CE   B MET A 1 253 ? -38.116 34.992 6.251   0.37 24.54 ? 219 MET A CE   1 
ATOM   3369 H H    A MET A 1 253 ? -33.442 34.780 2.230   0.63 21.19 ? 219 MET A H    1 
ATOM   3370 H H    B MET A 1 253 ? -33.340 34.813 2.201   0.37 21.07 ? 219 MET A H    1 
ATOM   3371 H HA   A MET A 1 253 ? -34.709 36.842 3.429   0.63 20.85 ? 219 MET A HA   1 
ATOM   3372 H HA   B MET A 1 253 ? -34.690 36.777 3.469   0.37 21.04 ? 219 MET A HA   1 
ATOM   3373 H HB2  A MET A 1 253 ? -35.574 34.995 4.317   0.63 22.38 ? 219 MET A HB2  1 
ATOM   3374 H HB2  B MET A 1 253 ? -34.899 34.282 3.909   0.37 22.40 ? 219 MET A HB2  1 
ATOM   3375 H HB3  A MET A 1 253 ? -34.179 34.234 4.310   0.63 22.38 ? 219 MET A HB3  1 
ATOM   3376 H HB3  B MET A 1 253 ? -33.742 34.624 4.943   0.37 22.40 ? 219 MET A HB3  1 
ATOM   3377 H HG2  A MET A 1 253 ? -33.514 35.214 6.206   0.63 27.68 ? 219 MET A HG2  1 
ATOM   3378 H HG2  B MET A 1 253 ? -35.470 34.894 6.248   0.37 26.03 ? 219 MET A HG2  1 
ATOM   3379 H HG3  A MET A 1 253 ? -34.602 36.366 6.083   0.63 27.68 ? 219 MET A HG3  1 
ATOM   3380 H HG3  B MET A 1 253 ? -35.369 36.371 5.672   0.37 26.03 ? 219 MET A HG3  1 
ATOM   3381 H HE1  A MET A 1 253 ? -37.187 35.528 8.269   0.63 26.38 ? 219 MET A HE1  1 
ATOM   3382 H HE1  B MET A 1 253 ? -39.005 34.690 6.009   0.37 29.48 ? 219 MET A HE1  1 
ATOM   3383 H HE2  A MET A 1 253 ? -36.336 36.613 7.481   0.63 26.38 ? 219 MET A HE2  1 
ATOM   3384 H HE2  B MET A 1 253 ? -37.667 34.312 6.777   0.37 29.48 ? 219 MET A HE2  1 
ATOM   3385 H HE3  A MET A 1 253 ? -37.426 35.748 6.714   0.63 26.38 ? 219 MET A HE3  1 
ATOM   3386 H HE3  B MET A 1 253 ? -38.174 35.817 6.757   0.37 29.48 ? 219 MET A HE3  1 
ATOM   3387 N N    . ILE A 1 254 ? -32.909 37.883 4.742   1.00 16.26 ? 220 ILE A N    1 
ATOM   3388 C CA   . ILE A 1 254 ? -31.856 38.475 5.561   1.00 13.73 ? 220 ILE A CA   1 
ATOM   3389 C C    . ILE A 1 254 ? -32.333 38.368 7.004   1.00 17.18 ? 220 ILE A C    1 
ATOM   3390 O O    . ILE A 1 254 ? -33.075 39.229 7.488   1.00 15.80 ? 220 ILE A O    1 
ATOM   3391 C CB   . ILE A 1 254 ? -31.567 39.938 5.180   1.00 14.39 ? 220 ILE A CB   1 
ATOM   3392 C CG1  . ILE A 1 254 ? -31.094 40.034 3.727   1.00 13.91 ? 220 ILE A CG1  1 
ATOM   3393 C CG2  . ILE A 1 254 ? -30.533 40.534 6.135   1.00 15.02 ? 220 ILE A CG2  1 
ATOM   3394 C CD1  . ILE A 1 254 ? -30.943 41.456 3.212   1.00 20.61 ? 220 ILE A CD1  1 
ATOM   3395 H H    A ILE A 1 254 ? -33.622 38.362 4.712   0.63 19.54 ? 220 ILE A H    1 
ATOM   3396 H H    B ILE A 1 254 ? -33.629 38.352 4.709   0.37 19.54 ? 220 ILE A H    1 
ATOM   3397 H HA   . ILE A 1 254 ? -31.024 37.993 5.437   1.00 16.50 ? 220 ILE A HA   1 
ATOM   3398 H HB   . ILE A 1 254 ? -32.389 40.448 5.260   1.00 17.30 ? 220 ILE A HB   1 
ATOM   3399 H HG12 . ILE A 1 254 ? -30.230 39.601 3.653   1.00 16.72 ? 220 ILE A HG12 1 
ATOM   3400 H HG13 . ILE A 1 254 ? -31.740 39.583 3.161   1.00 16.72 ? 220 ILE A HG13 1 
ATOM   3401 H HG21 . ILE A 1 254 ? -30.254 41.399 5.797   1.00 18.05 ? 220 ILE A HG21 1 
ATOM   3402 H HG22 . ILE A 1 254 ? -30.934 40.634 7.012   1.00 18.05 ? 220 ILE A HG22 1 
ATOM   3403 H HG23 . ILE A 1 254 ? -29.770 39.937 6.186   1.00 18.05 ? 220 ILE A HG23 1 
ATOM   3404 H HD11 . ILE A 1 254 ? -30.754 41.429 2.261   1.00 24.76 ? 220 ILE A HD11 1 
ATOM   3405 H HD12 . ILE A 1 254 ? -31.768 41.939 3.372   1.00 24.76 ? 220 ILE A HD12 1 
ATOM   3406 H HD13 . ILE A 1 254 ? -30.211 41.886 3.682   1.00 24.76 ? 220 ILE A HD13 1 
ATOM   3407 N N    . GLU A 1 255 ? -31.916 37.311 7.697   1.00 18.49 ? 221 GLU A N    1 
ATOM   3408 C CA   . GLU A 1 255 ? -32.557 36.950 8.956   1.00 18.54 ? 221 GLU A CA   1 
ATOM   3409 C C    . GLU A 1 255 ? -32.074 37.784 10.136  1.00 18.37 ? 221 GLU A C    1 
ATOM   3410 O O    . GLU A 1 255 ? -32.851 38.035 11.064  1.00 15.37 ? 221 GLU A O    1 
ATOM   3411 C CB   . GLU A 1 255 ? -32.319 35.466 9.244   1.00 23.93 ? 221 GLU A CB   1 
ATOM   3412 C CG   . GLU A 1 255 ? -33.437 34.799 10.006  1.00 26.27 ? 221 GLU A CG   1 
ATOM   3413 C CD   . GLU A 1 255 ? -32.948 33.676 10.901  1.00 33.94 ? 221 GLU A CD   1 
ATOM   3414 O OE1  . GLU A 1 255 ? -32.226 32.786 10.400  1.00 31.14 ? 221 GLU A OE1  1 
ATOM   3415 O OE2  . GLU A 1 255 ? -33.292 33.677 12.103  1.00 34.16 ? 221 GLU A OE2  1 
ATOM   3416 H H    . GLU A 1 255 ? -31.271 36.792 7.463   1.00 22.21 ? 221 GLU A H    1 
ATOM   3417 H HA   . GLU A 1 255 ? -33.510 37.106 8.865   1.00 22.28 ? 221 GLU A HA   1 
ATOM   3418 H HB2  . GLU A 1 255 ? -32.217 34.999 8.400   1.00 28.74 ? 221 GLU A HB2  1 
ATOM   3419 H HB3  . GLU A 1 255 ? -31.510 35.379 9.771   1.00 28.74 ? 221 GLU A HB3  1 
ATOM   3420 H HG2  . GLU A 1 255 ? -33.876 35.458 10.565  1.00 31.55 ? 221 GLU A HG2  1 
ATOM   3421 H HG3  . GLU A 1 255 ? -34.071 34.424 9.374   1.00 31.55 ? 221 GLU A HG3  1 
ATOM   3422 N N    . HIS A 1 256 ? -30.820 38.229 10.119  1.00 20.61 ? 222 HIS A N    1 
ATOM   3423 C CA   . HIS A 1 256 ? -30.137 38.703 11.316  1.00 17.00 ? 222 HIS A CA   1 
ATOM   3424 C C    . HIS A 1 256 ? -29.668 40.148 11.188  1.00 20.79 ? 222 HIS A C    1 
ATOM   3425 O O    . HIS A 1 256 ? -28.563 40.488 11.615  1.00 15.84 ? 222 HIS A O    1 
ATOM   3426 C CB   . HIS A 1 256 ? -28.935 37.812 11.628  1.00 18.10 ? 222 HIS A CB   1 
ATOM   3427 C CG   . HIS A 1 256 ? -29.297 36.467 12.172  1.00 19.87 ? 222 HIS A CG   1 
ATOM   3428 N ND1  . HIS A 1 256 ? -28.348 35.545 12.557  1.00 16.13 ? 222 HIS A ND1  1 
ATOM   3429 C CD2  . HIS A 1 256 ? -30.499 35.886 12.394  1.00 21.00 ? 222 HIS A CD2  1 
ATOM   3430 C CE1  . HIS A 1 256 ? -28.951 34.454 12.995  1.00 22.11 ? 222 HIS A CE1  1 
ATOM   3431 N NE2  . HIS A 1 256 ? -30.256 34.634 12.906  1.00 23.22 ? 222 HIS A NE2  1 
ATOM   3432 H H    . HIS A 1 256 ? -30.335 38.265 9.410   1.00 24.76 ? 222 HIS A H    1 
ATOM   3433 H HA   . HIS A 1 256 ? -30.776 38.667 12.044  1.00 20.43 ? 222 HIS A HA   1 
ATOM   3434 H HB2  . HIS A 1 256 ? -28.431 37.674 10.811  1.00 21.74 ? 222 HIS A HB2  1 
ATOM   3435 H HB3  . HIS A 1 256 ? -28.382 38.257 12.289  1.00 21.74 ? 222 HIS A HB3  1 
ATOM   3436 H HD2  . HIS A 1 256 ? -31.334 36.263 12.231  1.00 25.23 ? 222 HIS A HD2  1 
ATOM   3437 H HE1  . HIS A 1 256 ? -28.527 33.689 13.312  1.00 26.55 ? 222 HIS A HE1  1 
ATOM   3438 H HE2  . HIS A 1 256 ? -30.856 34.061 13.132  1.00 27.90 ? 222 HIS A HE2  1 
ATOM   3439 N N    . PHE A 1 257 ? -30.481 41.034 10.620  1.00 18.42 ? 223 PHE A N    1 
ATOM   3440 C CA   . PHE A 1 257 ? -30.010 42.404 10.464  1.00 15.90 ? 223 PHE A CA   1 
ATOM   3441 C C    . PHE A 1 257 ? -29.746 43.034 11.824  1.00 15.99 ? 223 PHE A C    1 
ATOM   3442 O O    . PHE A 1 257 ? -30.620 43.051 12.697  1.00 18.29 ? 223 PHE A O    1 
ATOM   3443 C CB   . PHE A 1 257 ? -30.997 43.275 9.701   1.00 16.19 ? 223 PHE A CB   1 
ATOM   3444 C CG   . PHE A 1 257 ? -30.513 44.687 9.545   1.00 17.29 ? 223 PHE A CG   1 
ATOM   3445 C CD1  . PHE A 1 257 ? -29.435 44.967 8.721   1.00 14.27 ? 223 PHE A CD1  1 
ATOM   3446 C CD2  . PHE A 1 257 ? -31.089 45.722 10.261  1.00 16.93 ? 223 PHE A CD2  1 
ATOM   3447 C CE1  . PHE A 1 257 ? -28.962 46.254 8.585   1.00 19.01 ? 223 PHE A CE1  1 
ATOM   3448 C CE2  . PHE A 1 257 ? -30.620 47.017 10.129  1.00 17.90 ? 223 PHE A CE2  1 
ATOM   3449 C CZ   . PHE A 1 257 ? -29.552 47.281 9.293   1.00 16.71 ? 223 PHE A CZ   1 
ATOM   3450 H H    . PHE A 1 257 ? -31.275 40.874 10.329  1.00 22.13 ? 223 PHE A H    1 
ATOM   3451 H HA   . PHE A 1 257 ? -29.189 42.368 9.948   1.00 19.11 ? 223 PHE A HA   1 
ATOM   3452 H HB2  . PHE A 1 257 ? -31.131 42.902 8.816   1.00 19.45 ? 223 PHE A HB2  1 
ATOM   3453 H HB3  . PHE A 1 257 ? -31.839 43.297 10.183  1.00 19.45 ? 223 PHE A HB3  1 
ATOM   3454 H HD1  . PHE A 1 257 ? -29.024 44.276 8.253   1.00 17.16 ? 223 PHE A HD1  1 
ATOM   3455 H HD2  . PHE A 1 257 ? -31.797 45.545 10.837  1.00 20.35 ? 223 PHE A HD2  1 
ATOM   3456 H HE1  . PHE A 1 257 ? -28.247 46.431 8.018   1.00 22.84 ? 223 PHE A HE1  1 
ATOM   3457 H HE2  . PHE A 1 257 ? -31.023 47.708 10.603  1.00 21.51 ? 223 PHE A HE2  1 
ATOM   3458 H HZ   . PHE A 1 257 ? -29.231 48.150 9.207   1.00 20.07 ? 223 PHE A HZ   1 
ATOM   3459 N N    . ALA A 1 258 ? -28.534 43.561 11.995  1.00 15.79 ? 224 ALA A N    1 
ATOM   3460 C CA   . ALA A 1 258 ? -28.165 44.323 13.185  1.00 17.73 ? 224 ALA A CA   1 
ATOM   3461 C C    . ALA A 1 258 ? -28.396 43.525 14.464  1.00 20.46 ? 224 ALA A C    1 
ATOM   3462 O O    . ALA A 1 258 ? -28.755 44.088 15.501  1.00 22.55 ? 224 ALA A O    1 
ATOM   3463 C CB   . ALA A 1 258 ? -28.929 45.648 13.244  1.00 18.52 ? 224 ALA A CB   1 
ATOM   3464 H H    . ALA A 1 258 ? -27.896 43.489 11.423  1.00 18.98 ? 224 ALA A H    1 
ATOM   3465 H HA   . ALA A 1 258 ? -27.217 44.519 13.135  1.00 21.30 ? 224 ALA A HA   1 
ATOM   3466 H HB1  . ALA A 1 258 ? -28.616 46.160 14.007  1.00 22.25 ? 224 ALA A HB1  1 
ATOM   3467 H HB2  . ALA A 1 258 ? -28.768 46.143 12.426  1.00 22.25 ? 224 ALA A HB2  1 
ATOM   3468 H HB3  . ALA A 1 258 ? -29.877 45.463 13.338  1.00 22.25 ? 224 ALA A HB3  1 
ATOM   3469 N N    . ASN A 1 259 ? -28.193 42.211 14.408  1.00 18.25 ? 225 ASN A N    1 
ATOM   3470 C CA   . ASN A 1 259 ? -28.397 41.371 15.577  1.00 17.47 ? 225 ASN A CA   1 
ATOM   3471 C C    . ASN A 1 259 ? -27.517 40.135 15.480  1.00 17.37 ? 225 ASN A C    1 
ATOM   3472 O O    . ASN A 1 259 ? -26.960 39.818 14.426  1.00 20.64 ? 225 ASN A O    1 
ATOM   3473 C CB   . ASN A 1 259 ? -29.865 40.962 15.727  1.00 19.29 ? 225 ASN A CB   1 
ATOM   3474 C CG   . ASN A 1 259 ? -30.253 40.716 17.171  1.00 24.34 ? 225 ASN A CG   1 
ATOM   3475 O OD1  . ASN A 1 259 ? -29.445 40.904 18.081  1.00 19.55 ? 225 ASN A OD1  1 
ATOM   3476 N ND2  . ASN A 1 259 ? -31.491 40.292 17.388  1.00 22.11 ? 225 ASN A ND2  1 
ATOM   3477 H H    . ASN A 1 259 ? -27.937 41.786 13.705  1.00 21.93 ? 225 ASN A H    1 
ATOM   3478 H HA   . ASN A 1 259 ? -28.129 41.874 16.361  1.00 21.00 ? 225 ASN A HA   1 
ATOM   3479 H HB2  . ASN A 1 259 ? -30.429 41.671 15.380  1.00 23.18 ? 225 ASN A HB2  1 
ATOM   3480 H HB3  . ASN A 1 259 ? -30.019 40.143 15.230  1.00 23.18 ? 225 ASN A HB3  1 
ATOM   3481 H HD21 . ASN A 1 259 ? -31.758 40.138 18.191  1.00 26.55 ? 225 ASN A HD21 1 
ATOM   3482 H HD22 . ASN A 1 259 ? -32.027 40.171 16.727  1.00 26.55 ? 225 ASN A HD22 1 
ATOM   3483 N N    . PHE A 1 260 ? -27.402 39.440 16.608  1.00 23.43 ? 226 PHE A N    1 
ATOM   3484 C CA   . PHE A 1 260 ? -26.680 38.168 16.697  1.00 19.78 ? 226 PHE A CA   1 
ATOM   3485 C C    . PHE A 1 260 ? -25.241 38.430 16.259  1.00 21.03 ? 226 PHE A C    1 
ATOM   3486 O O    . PHE A 1 260 ? -24.596 39.329 16.822  1.00 23.82 ? 226 PHE A O    1 
ATOM   3487 C CB   . PHE A 1 260 ? -27.449 37.127 15.897  1.00 21.19 ? 226 PHE A CB   1 
ATOM   3488 C CG   . PHE A 1 260 ? -28.861 36.935 16.371  1.00 17.91 ? 226 PHE A CG   1 
ATOM   3489 C CD1  . PHE A 1 260 ? -29.117 36.561 17.680  1.00 24.07 ? 226 PHE A CD1  1 
ATOM   3490 C CD2  . PHE A 1 260 ? -29.931 37.149 15.519  1.00 22.40 ? 226 PHE A CD2  1 
ATOM   3491 C CE1  . PHE A 1 260 ? -30.413 36.391 18.126  1.00 25.19 ? 226 PHE A CE1  1 
ATOM   3492 C CE2  . PHE A 1 260 ? -31.231 36.981 15.959  1.00 20.92 ? 226 PHE A CE2  1 
ATOM   3493 C CZ   . PHE A 1 260 ? -31.472 36.601 17.265  1.00 24.66 ? 226 PHE A CZ   1 
ATOM   3494 H H    . PHE A 1 260 ? -27.742 39.689 17.357  1.00 28.14 ? 226 PHE A H    1 
ATOM   3495 H HA   . PHE A 1 260 ? -26.635 37.876 17.620  1.00 23.76 ? 226 PHE A HA   1 
ATOM   3496 H HB2  . PHE A 1 260 ? -27.482 37.406 14.969  1.00 25.46 ? 226 PHE A HB2  1 
ATOM   3497 H HB3  . PHE A 1 260 ? -26.992 36.274 15.971  1.00 25.46 ? 226 PHE A HB3  1 
ATOM   3498 H HD1  . PHE A 1 260 ? -28.408 36.422 18.266  1.00 28.91 ? 226 PHE A HD1  1 
ATOM   3499 H HD2  . PHE A 1 260 ? -29.774 37.409 14.640  1.00 26.91 ? 226 PHE A HD2  1 
ATOM   3500 H HE1  . PHE A 1 260 ? -30.573 36.136 19.006  1.00 30.25 ? 226 PHE A HE1  1 
ATOM   3501 H HE2  . PHE A 1 260 ? -31.942 37.125 15.377  1.00 25.13 ? 226 PHE A HE2  1 
ATOM   3502 H HZ   . PHE A 1 260 ? -32.345 36.486 17.563  1.00 29.62 ? 226 PHE A HZ   1 
ATOM   3503 N N    . GLN A 1 261 ? -24.702 37.697 15.288  1.00 17.57 ? 227 GLN A N    1 
ATOM   3504 C CA   . GLN A 1 261 ? -23.326 37.884 14.851  1.00 23.03 ? 227 GLN A CA   1 
ATOM   3505 C C    . GLN A 1 261 ? -23.198 38.907 13.731  1.00 25.45 ? 227 GLN A C    1 
ATOM   3506 O O    . GLN A 1 261 ? -22.120 39.025 13.137  1.00 20.65 ? 227 GLN A O    1 
ATOM   3507 C CB   . GLN A 1 261 ? -22.733 36.548 14.396  1.00 23.42 ? 227 GLN A CB   1 
ATOM   3508 C CG   . GLN A 1 261 ? -22.813 35.447 15.437  1.00 24.06 ? 227 GLN A CG   1 
ATOM   3509 C CD   . GLN A 1 261 ? -22.376 34.103 14.889  1.00 36.55 ? 227 GLN A CD   1 
ATOM   3510 O OE1  . GLN A 1 261 ? -21.232 33.935 14.466  1.00 26.44 ? 227 GLN A OE1  1 
ATOM   3511 N NE2  . GLN A 1 261 ? -23.289 33.137 14.892  1.00 34.85 ? 227 GLN A NE2  1 
ATOM   3512 H H    . GLN A 1 261 ? -25.121 37.078 14.863  1.00 21.11 ? 227 GLN A H    1 
ATOM   3513 H HA   . GLN A 1 261 ? -22.806 38.201 15.606  1.00 27.66 ? 227 GLN A HA   1 
ATOM   3514 H HB2  . GLN A 1 261 ? -23.216 36.246 13.611  1.00 28.13 ? 227 GLN A HB2  1 
ATOM   3515 H HB3  . GLN A 1 261 ? -21.797 36.681 14.180  1.00 28.13 ? 227 GLN A HB3  1 
ATOM   3516 H HG2  . GLN A 1 261 ? -22.233 35.671 16.182  1.00 28.90 ? 227 GLN A HG2  1 
ATOM   3517 H HG3  . GLN A 1 261 ? -23.729 35.364 15.743  1.00 28.90 ? 227 GLN A HG3  1 
ATOM   3518 H HE21 . GLN A 1 261 ? -24.079 33.293 15.194  1.00 41.85 ? 227 GLN A HE21 1 
ATOM   3519 H HE22 . GLN A 1 261 ? -23.090 32.357 14.591  1.00 41.85 ? 227 GLN A HE22 1 
ATOM   3520 N N    . SER A 1 262 ? -24.264 39.652 13.436  1.00 19.02 ? 228 SER A N    1 
ATOM   3521 C CA   . SER A 1 262 ? -24.291 40.601 12.329  1.00 20.03 ? 228 SER A CA   1 
ATOM   3522 C C    . SER A 1 262 ? -24.490 42.030 12.825  1.00 17.86 ? 228 SER A C    1 
ATOM   3523 O O    . SER A 1 262 ? -25.129 42.843 12.154  1.00 21.70 ? 228 SER A O    1 
ATOM   3524 C CB   . SER A 1 262 ? -25.388 40.222 11.335  1.00 18.11 ? 228 SER A CB   1 
ATOM   3525 O OG   . SER A 1 262 ? -25.169 38.927 10.801  1.00 19.88 ? 228 SER A OG   1 
ATOM   3526 H H    . SER A 1 262 ? -25.002 39.622 13.875  1.00 22.85 ? 228 SER A H    1 
ATOM   3527 H HA   . SER A 1 262 ? -23.437 40.567 11.870  1.00 24.06 ? 228 SER A HA   1 
ATOM   3528 H HB2  . SER A 1 262 ? -26.244 40.234 11.791  1.00 21.75 ? 228 SER A HB2  1 
ATOM   3529 H HB3  . SER A 1 262 ? -25.390 40.865 10.609  1.00 21.75 ? 228 SER A HB3  1 
ATOM   3530 H HG   . SER A 1 262 ? -24.438 38.907 10.388  1.00 23.88 ? 228 SER A HG   1 
ATOM   3531 N N    . LYS A 1 263 ? -23.940 42.351 13.996  1.00 19.61 ? 229 LYS A N    1 
ATOM   3532 C CA   . LYS A 1 263 ? -24.148 43.656 14.608  1.00 19.39 ? 229 LYS A CA   1 
ATOM   3533 C C    . LYS A 1 263 ? -23.143 44.707 14.157  1.00 18.60 ? 229 LYS A C    1 
ATOM   3534 O O    . LYS A 1 263 ? -23.429 45.903 14.275  1.00 22.45 ? 229 LYS A O    1 
ATOM   3535 C CB   . LYS A 1 263 ? -24.081 43.538 16.134  1.00 21.81 ? 229 LYS A CB   1 
ATOM   3536 C CG   . LYS A 1 263 ? -25.175 42.679 16.741  1.00 20.01 ? 229 LYS A CG   1 
ATOM   3537 C CD   . LYS A 1 263 ? -25.116 42.726 18.259  1.00 25.80 ? 229 LYS A CD   1 
ATOM   3538 C CE   . LYS A 1 263 ? -25.934 41.611 18.893  1.00 23.07 ? 229 LYS A CE   1 
ATOM   3539 N NZ   . LYS A 1 263 ? -25.953 41.716 20.379  1.00 30.64 ? 229 LYS A NZ   1 
ATOM   3540 H H    . LYS A 1 263 ? -23.440 41.824 14.457  1.00 23.56 ? 229 LYS A H    1 
ATOM   3541 H HA   . LYS A 1 263 ? -25.033 43.967 14.362  1.00 23.29 ? 229 LYS A HA   1 
ATOM   3542 H HB2  . LYS A 1 263 ? -23.229 43.144 16.377  1.00 26.20 ? 229 LYS A HB2  1 
ATOM   3543 H HB3  . LYS A 1 263 ? -24.158 44.426 16.517  1.00 26.20 ? 229 LYS A HB3  1 
ATOM   3544 H HG2  . LYS A 1 263 ? -26.042 43.009 16.457  1.00 24.04 ? 229 LYS A HG2  1 
ATOM   3545 H HG3  . LYS A 1 263 ? -25.061 41.759 16.457  1.00 24.04 ? 229 LYS A HG3  1 
ATOM   3546 H HD2  . LYS A 1 263 ? -24.195 42.627 18.546  1.00 30.99 ? 229 LYS A HD2  1 
ATOM   3547 H HD3  . LYS A 1 263 ? -25.470 43.575 18.567  1.00 30.99 ? 229 LYS A HD3  1 
ATOM   3548 H HE2  . LYS A 1 263 ? -26.848 41.664 18.573  1.00 27.71 ? 229 LYS A HE2  1 
ATOM   3549 H HE3  . LYS A 1 263 ? -25.547 40.755 18.654  1.00 27.71 ? 229 LYS A HE3  1 
ATOM   3550 H HZ1  . LYS A 1 263 ? -26.393 41.025 20.727  1.00 36.80 ? 229 LYS A HZ1  1 
ATOM   3551 H HZ2  . LYS A 1 263 ? -25.121 41.717 20.695  1.00 36.80 ? 229 LYS A HZ2  1 
ATOM   3552 H HZ3  . LYS A 1 263 ? -26.357 42.469 20.626  1.00 36.80 ? 229 LYS A HZ3  1 
ATOM   3553 N N    . SER A 1 264 ? -21.980 44.301 13.655  1.00 19.15 ? 230 SER A N    1 
ATOM   3554 C CA   . SER A 1 264 ? -20.969 45.272 13.259  1.00 21.12 ? 230 SER A CA   1 
ATOM   3555 C C    . SER A 1 264 ? -21.492 46.159 12.134  1.00 20.30 ? 230 SER A C    1 
ATOM   3556 O O    . SER A 1 264 ? -22.364 45.767 11.354  1.00 16.64 ? 230 SER A O    1 
ATOM   3557 C CB   . SER A 1 264 ? -19.690 44.560 12.815  1.00 18.41 ? 230 SER A CB   1 
ATOM   3558 O OG   . SER A 1 264 ? -19.866 43.921 11.563  1.00 23.78 ? 230 SER A OG   1 
ATOM   3559 H H    . SER A 1 264 ? -21.755 43.480 13.536  1.00 23.00 ? 230 SER A H    1 
ATOM   3560 H HA   . SER A 1 264 ? -20.752 45.838 14.016  1.00 25.37 ? 230 SER A HA   1 
ATOM   3561 H HB2  . SER A 1 264 ? -18.978 45.214 12.737  1.00 22.12 ? 230 SER A HB2  1 
ATOM   3562 H HB3  . SER A 1 264 ? -19.456 43.893 13.479  1.00 22.12 ? 230 SER A HB3  1 
ATOM   3563 H HG   . SER A 1 264 ? -19.173 43.491 11.360  1.00 28.57 ? 230 SER A HG   1 
ATOM   3564 N N    . LYS A 1 265 ? -20.955 47.380 12.059  1.00 24.16 ? 231 LYS A N    1 
ATOM   3565 C CA   . LYS A 1 265 ? -21.328 48.263 10.959  1.00 22.91 ? 231 LYS A CA   1 
ATOM   3566 C C    . LYS A 1 265 ? -20.918 47.669 9.620   1.00 19.10 ? 231 LYS A C    1 
ATOM   3567 O O    . LYS A 1 265 ? -21.581 47.910 8.603   1.00 16.26 ? 231 LYS A O    1 
ATOM   3568 C CB   . LYS A 1 265 ? -20.712 49.655 11.141  1.00 23.31 ? 231 LYS A CB   1 
ATOM   3569 C CG   . LYS A 1 265 ? -19.260 49.699 11.609  1.00 28.40 ? 231 LYS A CG   1 
ATOM   3570 C CD   . LYS A 1 265 ? -18.867 51.124 11.981  1.00 26.85 ? 231 LYS A CD   1 
ATOM   3571 C CE   . LYS A 1 265 ? -17.359 51.317 11.999  1.00 27.12 ? 231 LYS A CE   1 
ATOM   3572 N NZ   . LYS A 1 265 ? -16.689 50.417 12.976  1.00 34.94 ? 231 LYS A NZ   1 
ATOM   3573 H H    . LYS A 1 265 ? -20.390 47.710 12.617  1.00 29.02 ? 231 LYS A H    1 
ATOM   3574 H HA   . LYS A 1 265 ? -22.291 48.376 10.966  1.00 27.52 ? 231 LYS A HA   1 
ATOM   3575 H HB2  . LYS A 1 265 ? -20.750 50.115 10.288  1.00 28.00 ? 231 LYS A HB2  1 
ATOM   3576 H HB3  . LYS A 1 265 ? -21.238 50.134 11.800  1.00 28.00 ? 231 LYS A HB3  1 
ATOM   3577 H HG2  . LYS A 1 265 ? -19.152 49.134 12.391  1.00 34.10 ? 231 LYS A HG2  1 
ATOM   3578 H HG3  . LYS A 1 265 ? -18.678 49.393 10.896  1.00 34.10 ? 231 LYS A HG3  1 
ATOM   3579 H HD2  . LYS A 1 265 ? -19.242 51.738 11.331  1.00 32.25 ? 231 LYS A HD2  1 
ATOM   3580 H HD3  . LYS A 1 265 ? -19.208 51.329 12.866  1.00 32.25 ? 231 LYS A HD3  1 
ATOM   3581 H HE2  . LYS A 1 265 ? -17.003 51.125 11.118  1.00 32.58 ? 231 LYS A HE2  1 
ATOM   3582 H HE3  . LYS A 1 265 ? -17.159 52.234 12.246  1.00 32.58 ? 231 LYS A HE3  1 
ATOM   3583 H HZ1  . LYS A 1 265 ? -15.811 50.564 12.972  1.00 41.96 ? 231 LYS A HZ1  1 
ATOM   3584 H HZ2  . LYS A 1 265 ? -17.004 50.568 13.794  1.00 41.96 ? 231 LYS A HZ2  1 
ATOM   3585 H HZ3  . LYS A 1 265 ? -16.841 49.567 12.760  1.00 41.96 ? 231 LYS A HZ3  1 
ATOM   3586 N N    . GLU A 1 266 ? -19.841 46.881 9.600   1.00 18.78 ? 232 GLU A N    1 
ATOM   3587 C CA   . GLU A 1 266 ? -19.457 46.187 8.375   1.00 21.84 ? 232 GLU A CA   1 
ATOM   3588 C C    . GLU A 1 266 ? -20.542 45.207 7.944   1.00 19.75 ? 232 GLU A C    1 
ATOM   3589 O O    . GLU A 1 266 ? -20.883 45.126 6.758   1.00 18.29 ? 232 GLU A O    1 
ATOM   3590 C CB   . GLU A 1 266 ? -18.131 45.447 8.573   1.00 25.41 ? 232 GLU A CB   1 
ATOM   3591 C CG   . GLU A 1 266 ? -16.894 46.328 8.765   1.00 35.70 ? 232 GLU A CG   1 
ATOM   3592 C CD   . GLU A 1 266 ? -16.930 47.160 10.037  1.00 39.22 ? 232 GLU A CD   1 
ATOM   3593 O OE1  . GLU A 1 266 ? -16.272 48.224 10.067  1.00 32.61 ? 232 GLU A OE1  1 
ATOM   3594 O OE2  . GLU A 1 266 ? -17.613 46.754 11.003  1.00 28.98 ? 232 GLU A OE2  1 
ATOM   3595 H H    . GLU A 1 266 ? -19.325 46.734 10.272  1.00 22.56 ? 232 GLU A H    1 
ATOM   3596 H HA   . GLU A 1 266 ? -19.333 46.845 7.673   1.00 26.23 ? 232 GLU A HA   1 
ATOM   3597 H HB2  . GLU A 1 266 ? -18.210 44.889 9.363   1.00 30.52 ? 232 GLU A HB2  1 
ATOM   3598 H HB3  . GLU A 1 266 ? -17.972 44.896 7.792   1.00 30.52 ? 232 GLU A HB3  1 
ATOM   3599 H HG2  . GLU A 1 266 ? -16.109 45.759 8.804   1.00 42.87 ? 232 GLU A HG2  1 
ATOM   3600 H HG3  . GLU A 1 266 ? -16.825 46.937 8.013   1.00 42.87 ? 232 GLU A HG3  1 
ATOM   3601 N N    . SER A 1 267 ? -21.098 44.455 8.897   1.00 17.08 ? 233 SER A N    1 
ATOM   3602 C CA   . SER A 1 267 ? -22.104 43.454 8.559   1.00 18.89 ? 233 SER A CA   1 
ATOM   3603 C C    . SER A 1 267 ? -23.440 44.103 8.220   1.00 16.03 ? 233 SER A C    1 
ATOM   3604 O O    . SER A 1 267 ? -24.163 43.624 7.339   1.00 14.35 ? 233 SER A O    1 
ATOM   3605 C CB   . SER A 1 267 ? -22.270 42.472 9.717   1.00 18.46 ? 233 SER A CB   1 
ATOM   3606 O OG   . SER A 1 267 ? -21.057 41.793 9.981   1.00 21.39 ? 233 SER A OG   1 
ATOM   3607 H H    . SER A 1 267 ? -20.911 44.505 9.735   1.00 20.52 ? 233 SER A H    1 
ATOM   3608 H HA   . SER A 1 267 ? -21.803 42.960 7.781   1.00 22.70 ? 233 SER A HA   1 
ATOM   3609 H HB2  . SER A 1 267 ? -22.537 42.962 10.511  1.00 22.18 ? 233 SER A HB2  1 
ATOM   3610 H HB3  . SER A 1 267 ? -22.951 41.821 9.484   1.00 22.18 ? 233 SER A HB3  1 
ATOM   3611 H HG   . SER A 1 267 ? -20.471 42.340 10.232  1.00 25.69 ? 233 SER A HG   1 
ATOM   3612 N N    . MET A 1 268 ? -23.790 45.187 8.914   1.00 15.84 ? 234 MET A N    1 
ATOM   3613 C CA   . MET A 1 268 ? -25.038 45.875 8.604   1.00 20.09 ? 234 MET A CA   1 
ATOM   3614 C C    . MET A 1 268 ? -24.992 46.486 7.209   1.00 17.31 ? 234 MET A C    1 
ATOM   3615 O O    . MET A 1 268 ? -25.963 46.387 6.450   1.00 17.82 ? 234 MET A O    1 
ATOM   3616 C CB   . MET A 1 268 ? -25.323 46.948 9.653   1.00 17.70 ? 234 MET A CB   1 
ATOM   3617 C CG   . MET A 1 268 ? -25.695 46.385 11.019  1.00 15.65 ? 234 MET A CG   1 
ATOM   3618 S SD   . MET A 1 268 ? -26.190 47.663 12.184  1.00 17.46 ? 234 MET A SD   1 
ATOM   3619 C CE   . MET A 1 268 ? -24.618 48.455 12.509  1.00 18.83 ? 234 MET A CE   1 
ATOM   3620 H H    . MET A 1 268 ? -23.333 45.535 9.554   1.00 19.03 ? 234 MET A H    1 
ATOM   3621 H HA   . MET A 1 268 ? -25.763 45.232 8.640   1.00 24.14 ? 234 MET A HA   1 
ATOM   3622 H HB2  . MET A 1 268 ? -24.530 47.495 9.764   1.00 21.26 ? 234 MET A HB2  1 
ATOM   3623 H HB3  . MET A 1 268 ? -26.063 47.495 9.347   1.00 21.26 ? 234 MET A HB3  1 
ATOM   3624 H HG2  . MET A 1 268 ? -26.437 45.768 10.916  1.00 18.81 ? 234 MET A HG2  1 
ATOM   3625 H HG3  . MET A 1 268 ? -24.927 45.921 11.390  1.00 18.81 ? 234 MET A HG3  1 
ATOM   3626 H HE1  . MET A 1 268 ? -24.741 49.134 13.191  1.00 22.63 ? 234 MET A HE1  1 
ATOM   3627 H HE2  . MET A 1 268 ? -23.985 47.787 12.817  1.00 22.63 ? 234 MET A HE2  1 
ATOM   3628 H HE3  . MET A 1 268 ? -24.295 48.863 11.690  1.00 22.63 ? 234 MET A HE3  1 
ATOM   3629 N N    . LEU A 1 269 ? -23.872 47.117 6.849   1.00 19.82 ? 235 LEU A N    1 
ATOM   3630 C CA   . LEU A 1 269 ? -23.731 47.647 5.497   1.00 17.62 ? 235 LEU A CA   1 
ATOM   3631 C C    . LEU A 1 269 ? -23.833 46.531 4.467   1.00 16.59 ? 235 LEU A C    1 
ATOM   3632 O O    . LEU A 1 269 ? -24.515 46.671 3.446   1.00 17.46 ? 235 LEU A O    1 
ATOM   3633 C CB   . LEU A 1 269 ? -22.398 48.383 5.353   1.00 16.78 ? 235 LEU A CB   1 
ATOM   3634 C CG   . LEU A 1 269 ? -22.104 48.907 3.944   1.00 22.02 ? 235 LEU A CG   1 
ATOM   3635 C CD1  . LEU A 1 269 ? -23.145 49.942 3.532   1.00 15.51 ? 235 LEU A CD1  1 
ATOM   3636 C CD2  . LEU A 1 269 ? -20.702 49.484 3.858   1.00 15.28 ? 235 LEU A CD2  1 
ATOM   3637 H H    . LEU A 1 269 ? -23.193 47.247 7.360   1.00 23.82 ? 235 LEU A H    1 
ATOM   3638 H HA   . LEU A 1 269 ? -24.443 48.285 5.334   1.00 21.18 ? 235 LEU A HA   1 
ATOM   3639 H HB2  . LEU A 1 269 ? -22.401 49.145 5.954   1.00 20.17 ? 235 LEU A HB2  1 
ATOM   3640 H HB3  . LEU A 1 269 ? -21.683 47.773 5.594   1.00 20.17 ? 235 LEU A HB3  1 
ATOM   3641 H HG   . LEU A 1 269 ? -22.152 48.167 3.319   1.00 26.45 ? 235 LEU A HG   1 
ATOM   3642 H HD11 . LEU A 1 269 ? -22.886 50.329 2.681   1.00 18.64 ? 235 LEU A HD11 1 
ATOM   3643 H HD12 . LEU A 1 269 ? -24.008 49.506 3.447   1.00 18.64 ? 235 LEU A HD12 1 
ATOM   3644 H HD13 . LEU A 1 269 ? -23.189 50.633 4.210   1.00 18.64 ? 235 LEU A HD13 1 
ATOM   3645 H HD21 . LEU A 1 269 ? -20.551 49.815 2.959   1.00 18.36 ? 235 LEU A HD21 1 
ATOM   3646 H HD22 . LEU A 1 269 ? -20.621 50.211 4.496   1.00 18.36 ? 235 LEU A HD22 1 
ATOM   3647 H HD23 . LEU A 1 269 ? -20.061 48.788 4.067   1.00 18.36 ? 235 LEU A HD23 1 
ATOM   3648 N N    . GLN A 1 270 ? -23.151 45.413 4.719   1.00 18.46 ? 236 GLN A N    1 
ATOM   3649 C CA   . GLN A 1 270 ? -23.193 44.297 3.782   1.00 19.14 ? 236 GLN A CA   1 
ATOM   3650 C C    . GLN A 1 270 ? -24.614 43.779 3.613   1.00 16.61 ? 236 GLN A C    1 
ATOM   3651 O O    . GLN A 1 270 ? -25.055 43.507 2.490   1.00 14.48 ? 236 GLN A O    1 
ATOM   3652 C CB   . GLN A 1 270 ? -22.267 43.177 4.260   1.00 20.55 ? 236 GLN A CB   1 
ATOM   3653 C CG   . GLN A 1 270 ? -21.829 42.208 3.168   1.00 22.73 ? 236 GLN A CG   1 
ATOM   3654 C CD   . GLN A 1 270 ? -21.210 42.906 1.974   1.00 27.92 ? 236 GLN A CD   1 
ATOM   3655 O OE1  . GLN A 1 270 ? -20.400 43.821 2.126   1.00 26.87 ? 236 GLN A OE1  1 
ATOM   3656 N NE2  . GLN A 1 270 ? -21.599 42.484 0.776   1.00 31.46 ? 236 GLN A NE2  1 
ATOM   3657 H H    . GLN A 1 270 ? -22.664 45.278 5.415   1.00 22.18 ? 236 GLN A H    1 
ATOM   3658 H HA   . GLN A 1 270 ? -22.877 44.600 2.916   1.00 22.99 ? 236 GLN A HA   1 
ATOM   3659 H HB2  . GLN A 1 270 ? -21.466 43.578 4.635   1.00 24.68 ? 236 GLN A HB2  1 
ATOM   3660 H HB3  . GLN A 1 270 ? -22.730 42.663 4.940   1.00 24.68 ? 236 GLN A HB3  1 
ATOM   3661 H HG2  . GLN A 1 270 ? -21.170 41.597 3.534   1.00 27.31 ? 236 GLN A HG2  1 
ATOM   3662 H HG3  . GLN A 1 270 ? -22.603 41.712 2.857   1.00 27.31 ? 236 GLN A HG3  1 
ATOM   3663 H HE21 . GLN A 1 270 ? -22.173 41.848 0.710   1.00 37.78 ? 236 GLN A HE21 1 
ATOM   3664 H HE22 . GLN A 1 270 ? -21.277 42.849 0.067   1.00 37.78 ? 236 GLN A HE22 1 
ATOM   3665 N N    . ASP A 1 271 ? -25.347 43.632 4.719   1.00 16.86 ? 237 ASP A N    1 
ATOM   3666 C CA   . ASP A 1 271 ? -26.727 43.166 4.627   1.00 15.27 ? 237 ASP A CA   1 
ATOM   3667 C C    . ASP A 1 271 ? -27.562 44.091 3.750   1.00 15.05 ? 237 ASP A C    1 
ATOM   3668 O O    . ASP A 1 271 ? -28.348 43.626 2.917   1.00 18.29 ? 237 ASP A O    1 
ATOM   3669 C CB   . ASP A 1 271 ? -27.340 43.060 6.023   1.00 17.64 ? 237 ASP A CB   1 
ATOM   3670 C CG   . ASP A 1 271 ? -26.995 41.757 6.715   1.00 18.41 ? 237 ASP A CG   1 
ATOM   3671 O OD1  . ASP A 1 271 ? -26.458 40.848 6.047   1.00 12.52 ? 237 ASP A OD1  1 
ATOM   3672 O OD2  . ASP A 1 271 ? -27.270 41.642 7.926   1.00 15.33 ? 237 ASP A OD2  1 
ATOM   3673 H H    . ASP A 1 271 ? -25.073 43.792 5.518   1.00 20.26 ? 237 ASP A H    1 
ATOM   3674 H HA   . ASP A 1 271 ? -26.732 42.283 4.227   1.00 18.35 ? 237 ASP A HA   1 
ATOM   3675 H HB2  . ASP A 1 271 ? -27.008 43.788 6.571   1.00 21.20 ? 237 ASP A HB2  1 
ATOM   3676 H HB3  . ASP A 1 271 ? -28.306 43.115 5.949   1.00 21.20 ? 237 ASP A HB3  1 
ATOM   3677 N N    . ILE A 1 272 ? -27.405 45.405 3.919   1.00 13.40 ? 238 ILE A N    1 
ATOM   3678 C CA   . ILE A 1 272 ? -28.196 46.343 3.130   1.00 17.10 ? 238 ILE A CA   1 
ATOM   3679 C C    . ILE A 1 272 ? -27.783 46.285 1.664   1.00 17.17 ? 238 ILE A C    1 
ATOM   3680 O O    . ILE A 1 272 ? -28.635 46.284 0.767   1.00 13.61 ? 238 ILE A O    1 
ATOM   3681 C CB   . ILE A 1 272 ? -28.070 47.768 3.699   1.00 11.52 ? 238 ILE A CB   1 
ATOM   3682 C CG1  . ILE A 1 272 ? -28.590 47.816 5.138   1.00 17.09 ? 238 ILE A CG1  1 
ATOM   3683 C CG2  . ILE A 1 272 ? -28.839 48.755 2.832   1.00 15.57 ? 238 ILE A CG2  1 
ATOM   3684 C CD1  . ILE A 1 272 ? -28.169 49.057 5.905   1.00 15.43 ? 238 ILE A CD1  1 
ATOM   3685 H H    . ILE A 1 272 ? -26.858 45.770 4.473   1.00 16.10 ? 238 ILE A H    1 
ATOM   3686 H HA   . ILE A 1 272 ? -29.129 46.083 3.189   1.00 20.55 ? 238 ILE A HA   1 
ATOM   3687 H HB   . ILE A 1 272 ? -27.131 48.013 3.698   1.00 13.85 ? 238 ILE A HB   1 
ATOM   3688 H HG12 . ILE A 1 272 ? -29.560 47.795 5.119   1.00 20.54 ? 238 ILE A HG12 1 
ATOM   3689 H HG13 . ILE A 1 272 ? -28.252 47.044 5.617   1.00 20.54 ? 238 ILE A HG13 1 
ATOM   3690 H HG21 . ILE A 1 272 ? -28.888 49.608 3.291   1.00 18.71 ? 238 ILE A HG21 1 
ATOM   3691 H HG22 . ILE A 1 272 ? -28.376 48.860 1.986   1.00 18.71 ? 238 ILE A HG22 1 
ATOM   3692 H HG23 . ILE A 1 272 ? -29.733 48.410 2.679   1.00 18.71 ? 238 ILE A HG23 1 
ATOM   3693 H HD11 . ILE A 1 272 ? -28.439 48.962 6.832   1.00 18.54 ? 238 ILE A HD11 1 
ATOM   3694 H HD12 . ILE A 1 272 ? -27.206 49.151 5.849   1.00 18.54 ? 238 ILE A HD12 1 
ATOM   3695 H HD13 . ILE A 1 272 ? -28.600 49.832 5.512   1.00 18.54 ? 238 ILE A HD13 1 
ATOM   3696 N N    . LEU A 1 273 ? -26.475 46.231 1.395   1.00 13.99 ? 239 LEU A N    1 
ATOM   3697 C CA   . LEU A 1 273 ? -26.016 46.122 0.014   1.00 15.25 ? 239 LEU A CA   1 
ATOM   3698 C C    . LEU A 1 273 ? -26.495 44.828 -0.629  1.00 13.98 ? 239 LEU A C    1 
ATOM   3699 O O    . LEU A 1 273 ? -26.782 44.801 -1.831  1.00 15.27 ? 239 LEU A O    1 
ATOM   3700 C CB   . LEU A 1 273 ? -24.490 46.202 -0.052  1.00 15.86 ? 239 LEU A CB   1 
ATOM   3701 C CG   . LEU A 1 273 ? -23.846 47.546 0.293   1.00 18.89 ? 239 LEU A CG   1 
ATOM   3702 C CD1  . LEU A 1 273 ? -22.351 47.373 0.523   1.00 15.80 ? 239 LEU A CD1  1 
ATOM   3703 C CD2  . LEU A 1 273 ? -24.107 48.570 -0.801  1.00 18.54 ? 239 LEU A CD2  1 
ATOM   3704 H H    . LEU A 1 273 ? -25.847 46.257 1.983   1.00 16.82 ? 239 LEU A H    1 
ATOM   3705 H HA   . LEU A 1 273 ? -26.378 46.868 -0.489  1.00 18.33 ? 239 LEU A HA   1 
ATOM   3706 H HB2  . LEU A 1 273 ? -24.130 45.549 0.568   1.00 19.06 ? 239 LEU A HB2  1 
ATOM   3707 H HB3  . LEU A 1 273 ? -24.219 45.984 -0.958  1.00 19.06 ? 239 LEU A HB3  1 
ATOM   3708 H HG   . LEU A 1 273 ? -24.242 47.883 1.112   1.00 22.69 ? 239 LEU A HG   1 
ATOM   3709 H HD11 . LEU A 1 273 ? -21.958 48.239 0.716   1.00 18.98 ? 239 LEU A HD11 1 
ATOM   3710 H HD12 . LEU A 1 273 ? -22.214 46.773 1.272   1.00 18.98 ? 239 LEU A HD12 1 
ATOM   3711 H HD13 . LEU A 1 273 ? -21.950 46.999 -0.278  1.00 18.98 ? 239 LEU A HD13 1 
ATOM   3712 H HD21 . LEU A 1 273 ? -23.664 49.401 -0.567  1.00 22.27 ? 239 LEU A HD21 1 
ATOM   3713 H HD22 . LEU A 1 273 ? -23.756 48.233 -1.640  1.00 22.27 ? 239 LEU A HD22 1 
ATOM   3714 H HD23 . LEU A 1 273 ? -25.063 48.715 -0.877  1.00 22.27 ? 239 LEU A HD23 1 
ATOM   3715 N N    . GLU A 1 274 ? -26.581 43.744 0.146   1.00 18.11 ? 240 GLU A N    1 
ATOM   3716 C CA   . GLU A 1 274 ? -27.027 42.480 -0.429  1.00 17.13 ? 240 GLU A CA   1 
ATOM   3717 C C    . GLU A 1 274 ? -28.514 42.513 -0.752  1.00 16.24 ? 240 GLU A C    1 
ATOM   3718 O O    . GLU A 1 274 ? -28.945 41.899 -1.735  1.00 18.03 ? 240 GLU A O    1 
ATOM   3719 C CB   . GLU A 1 274 ? -26.703 41.324 0.517   1.00 16.39 ? 240 GLU A CB   1 
ATOM   3720 C CG   . GLU A 1 274 ? -25.209 41.045 0.654   1.00 22.47 ? 240 GLU A CG   1 
ATOM   3721 C CD   . GLU A 1 274 ? -24.602 40.431 -0.597  1.00 21.45 ? 240 GLU A CD   1 
ATOM   3722 O OE1  . GLU A 1 274 ? -25.362 39.910 -1.439  1.00 24.86 ? 240 GLU A OE1  1 
ATOM   3723 O OE2  . GLU A 1 274 ? -23.362 40.473 -0.739  1.00 24.18 ? 240 GLU A OE2  1 
ATOM   3724 H H    . GLU A 1 274 ? -26.392 43.717 0.984   1.00 21.76 ? 240 GLU A H    1 
ATOM   3725 H HA   . GLU A 1 274 ? -26.545 42.322 -1.256  1.00 20.58 ? 240 GLU A HA   1 
ATOM   3726 H HB2  . GLU A 1 274 ? -27.047 41.536 1.399   1.00 19.69 ? 240 GLU A HB2  1 
ATOM   3727 H HB3  . GLU A 1 274 ? -27.126 40.518 0.181   1.00 19.69 ? 240 GLU A HB3  1 
ATOM   3728 H HG2  . GLU A 1 274 ? -24.748 41.879 0.832   1.00 26.99 ? 240 GLU A HG2  1 
ATOM   3729 H HG3  . GLU A 1 274 ? -25.070 40.426 1.388   1.00 26.99 ? 240 GLU A HG3  1 
ATOM   3730 N N    . MET A 1 275 ? -29.313 43.224 0.047   1.00 15.90 ? 241 MET A N    1 
ATOM   3731 C CA   . MET A 1 275 ? -30.717 43.409 -0.304  1.00 16.85 ? 241 MET A CA   1 
ATOM   3732 C C    . MET A 1 275 ? -30.842 44.216 -1.589  1.00 15.61 ? 241 MET A C    1 
ATOM   3733 O O    . MET A 1 275 ? -31.556 43.821 -2.517  1.00 15.94 ? 241 MET A O    1 
ATOM   3734 C CB   . MET A 1 275 ? -31.469 44.092 0.841   1.00 14.77 ? 241 MET A CB   1 
ATOM   3735 C CG   . MET A 1 275 ? -32.721 44.853 0.404   1.00 16.85 ? 241 MET A CG   1 
ATOM   3736 S SD   . MET A 1 275 ? -33.668 45.505 1.795   1.00 17.07 ? 241 MET A SD   1 
ATOM   3737 C CE   . MET A 1 275 ? -32.576 46.820 2.323   1.00 14.58 ? 241 MET A CE   1 
ATOM   3738 H H    . MET A 1 275 ? -29.070 43.601 0.781   1.00 19.10 ? 241 MET A H    1 
ATOM   3739 H HA   . MET A 1 275 ? -31.121 42.537 -0.433  1.00 20.24 ? 241 MET A HA   1 
ATOM   3740 H HB2  . MET A 1 275 ? -31.744 43.415 1.479   1.00 17.75 ? 241 MET A HB2  1 
ATOM   3741 H HB3  . MET A 1 275 ? -30.872 44.727 1.268   1.00 17.75 ? 241 MET A HB3  1 
ATOM   3742 H HG2  . MET A 1 275 ? -32.457 45.600 -0.155  1.00 20.25 ? 241 MET A HG2  1 
ATOM   3743 H HG3  . MET A 1 275 ? -33.297 44.253 -0.095  1.00 20.25 ? 241 MET A HG3  1 
ATOM   3744 H HE1  . MET A 1 275 ? -32.986 47.292 3.065   1.00 17.53 ? 241 MET A HE1  1 
ATOM   3745 H HE2  . MET A 1 275 ? -31.731 46.435 2.602   1.00 17.53 ? 241 MET A HE2  1 
ATOM   3746 H HE3  . MET A 1 275 ? -32.434 47.429 1.581   1.00 17.53 ? 241 MET A HE3  1 
ATOM   3747 N N    . GLU A 1 276 ? -30.146 45.355 -1.661  1.00 15.29 ? 242 GLU A N    1 
ATOM   3748 C CA   . GLU A 1 276 ? -30.173 46.162 -2.875  1.00 15.92 ? 242 GLU A CA   1 
ATOM   3749 C C    . GLU A 1 276 ? -29.737 45.338 -4.079  1.00 18.00 ? 242 GLU A C    1 
ATOM   3750 O O    . GLU A 1 276 ? -30.397 45.343 -5.124  1.00 16.36 ? 242 GLU A O    1 
ATOM   3751 C CB   . GLU A 1 276 ? -29.272 47.389 -2.712  1.00 15.15 ? 242 GLU A CB   1 
ATOM   3752 C CG   . GLU A 1 276 ? -29.002 48.141 -4.017  1.00 19.04 ? 242 GLU A CG   1 
ATOM   3753 C CD   . GLU A 1 276 ? -28.053 49.309 -3.844  1.00 21.43 ? 242 GLU A CD   1 
ATOM   3754 O OE1  . GLU A 1 276 ? -27.054 49.163 -3.108  1.00 18.17 ? 242 GLU A OE1  1 
ATOM   3755 O OE2  . GLU A 1 276 ? -28.303 50.372 -4.450  1.00 20.57 ? 242 GLU A OE2  1 
ATOM   3756 H H    . GLU A 1 276 ? -29.659 45.675 -1.028  1.00 18.37 ? 242 GLU A H    1 
ATOM   3757 H HA   . GLU A 1 276 ? -31.079 46.473 -3.027  1.00 19.14 ? 242 GLU A HA   1 
ATOM   3758 H HB2  . GLU A 1 276 ? -29.697 48.008 -2.098  1.00 18.21 ? 242 GLU A HB2  1 
ATOM   3759 H HB3  . GLU A 1 276 ? -28.417 47.102 -2.355  1.00 18.21 ? 242 GLU A HB3  1 
ATOM   3760 H HG2  . GLU A 1 276 ? -28.608 47.529 -4.657  1.00 22.88 ? 242 GLU A HG2  1 
ATOM   3761 H HG3  . GLU A 1 276 ? -29.841 48.486 -4.361  1.00 22.88 ? 242 GLU A HG3  1 
ATOM   3762 N N    . LYS A 1 277 ? -28.618 44.625 -3.944  1.00 17.67 ? 243 LYS A N    1 
ATOM   3763 C CA   . LYS A 1 277 ? -28.100 43.824 -5.046  1.00 22.49 ? 243 LYS A CA   1 
ATOM   3764 C C    . LYS A 1 277 ? -29.097 42.747 -5.454  1.00 18.87 ? 243 LYS A C    1 
ATOM   3765 O O    . LYS A 1 277 ? -29.383 42.569 -6.642  1.00 15.89 ? 243 LYS A O    1 
ATOM   3766 C CB   . LYS A 1 277 ? -26.762 43.203 -4.639  1.00 19.45 ? 243 LYS A CB   1 
ATOM   3767 C CG   . LYS A 1 277 ? -25.965 42.566 -5.766  1.00 22.71 ? 243 LYS A CG   1 
ATOM   3768 C CD   . LYS A 1 277 ? -24.687 41.932 -5.206  1.00 27.18 ? 243 LYS A CD   1 
ATOM   3769 C CE   . LYS A 1 277 ? -23.620 41.648 -6.263  1.00 33.39 ? 243 LYS A CE   1 
ATOM   3770 N NZ   . LYS A 1 277 ? -23.710 42.501 -7.482  1.00 45.17 ? 243 LYS A NZ   1 
ATOM   3771 H H    . LYS A 1 277 ? -28.144 44.588 -3.227  1.00 21.24 ? 243 LYS A H    1 
ATOM   3772 H HA   . LYS A 1 277 ? -27.949 44.394 -5.816  1.00 27.02 ? 243 LYS A HA   1 
ATOM   3773 H HB2  . LYS A 1 277 ? -26.209 43.900 -4.252  1.00 23.36 ? 243 LYS A HB2  1 
ATOM   3774 H HB3  . LYS A 1 277 ? -26.935 42.512 -3.981  1.00 23.36 ? 243 LYS A HB3  1 
ATOM   3775 H HG2  . LYS A 1 277 ? -26.495 41.874 -6.192  1.00 27.28 ? 243 LYS A HG2  1 
ATOM   3776 H HG3  . LYS A 1 277 ? -25.718 43.242 -6.416  1.00 27.28 ? 243 LYS A HG3  1 
ATOM   3777 H HD2  . LYS A 1 277 ? -24.300 42.535 -4.552  1.00 32.64 ? 243 LYS A HD2  1 
ATOM   3778 H HD3  . LYS A 1 277 ? -24.916 41.088 -4.785  1.00 32.64 ? 243 LYS A HD3  1 
ATOM   3779 H HE2  . LYS A 1 277 ? -22.746 41.795 -5.868  1.00 40.10 ? 243 LYS A HE2  1 
ATOM   3780 H HE3  . LYS A 1 277 ? -23.704 40.724 -6.547  1.00 40.10 ? 243 LYS A HE3  1 
ATOM   3781 H HZ1  . LYS A 1 277 ? -23.029 42.325 -8.027  1.00 54.23 ? 243 LYS A HZ1  1 
ATOM   3782 H HZ2  . LYS A 1 277 ? -24.473 42.340 -7.911  1.00 54.23 ? 243 LYS A HZ2  1 
ATOM   3783 H HZ3  . LYS A 1 277 ? -23.682 43.361 -7.254  1.00 54.23 ? 243 LYS A HZ3  1 
ATOM   3784 N N    . ALA A 1 278 ? -29.646 42.023 -4.476  1.00 17.68 ? 244 ALA A N    1 
ATOM   3785 C CA   . ALA A 1 278 ? -30.594 40.957 -4.788  1.00 13.95 ? 244 ALA A CA   1 
ATOM   3786 C C    . ALA A 1 278 ? -31.878 41.515 -5.388  1.00 21.04 ? 244 ALA A C    1 
ATOM   3787 O O    . ALA A 1 278 ? -32.393 40.979 -6.377  1.00 15.68 ? 244 ALA A O    1 
ATOM   3788 C CB   . ALA A 1 278 ? -30.903 40.144 -3.531  1.00 20.99 ? 244 ALA A CB   1 
ATOM   3789 H H    . ALA A 1 278 ? -29.488 42.128 -3.637  1.00 21.25 ? 244 ALA A H    1 
ATOM   3790 H HA   . ALA A 1 278 ? -30.189 40.364 -5.440  1.00 16.76 ? 244 ALA A HA   1 
ATOM   3791 H HB1  . ALA A 1 278 ? -31.518 39.429 -3.761  1.00 25.21 ? 244 ALA A HB1  1 
ATOM   3792 H HB2  . ALA A 1 278 ? -30.077 39.772 -3.185  1.00 25.21 ? 244 ALA A HB2  1 
ATOM   3793 H HB3  . ALA A 1 278 ? -31.307 40.727 -2.870  1.00 25.21 ? 244 ALA A HB3  1 
ATOM   3794 N N    . GLY A 1 279 ? -32.413 42.587 -4.802  1.00 14.58 ? 245 GLY A N    1 
ATOM   3795 C CA   . GLY A 1 279 ? -33.622 43.182 -5.344  1.00 14.28 ? 245 GLY A CA   1 
ATOM   3796 C C    . GLY A 1 279 ? -33.451 43.636 -6.780  1.00 17.23 ? 245 GLY A C    1 
ATOM   3797 O O    . GLY A 1 279 ? -34.378 43.538 -7.586  1.00 15.39 ? 245 GLY A O    1 
ATOM   3798 H H    . GLY A 1 279 ? -32.098 42.979 -4.104  1.00 17.52 ? 245 GLY A H    1 
ATOM   3799 H HA2  . GLY A 1 279 ? -34.340 42.531 -5.313  1.00 17.16 ? 245 GLY A HA2  1 
ATOM   3800 H HA3  . GLY A 1 279 ? -33.869 43.951 -4.807  1.00 17.16 ? 245 GLY A HA3  1 
ATOM   3801 N N    . LYS A 1 280 ? -32.261 44.139 -7.119  1.00 19.94 ? 246 LYS A N    1 
ATOM   3802 C CA   . LYS A 1 280 ? -32.006 44.607 -8.477  1.00 19.04 ? 246 LYS A CA   1 
ATOM   3803 C C    . LYS A 1 280 ? -31.993 43.469 -9.489  1.00 19.31 ? 246 LYS A C    1 
ATOM   3804 O O    . LYS A 1 280 ? -32.239 43.712 -10.676 1.00 21.58 ? 246 LYS A O    1 
ATOM   3805 C CB   . LYS A 1 280 ? -30.677 45.365 -8.532  1.00 21.15 ? 246 LYS A CB   1 
ATOM   3806 C CG   . LYS A 1 280 ? -30.766 46.815 -8.071  1.00 22.52 ? 246 LYS A CG   1 
ATOM   3807 C CD   . LYS A 1 280 ? -29.395 47.356 -7.687  1.00 24.15 ? 246 LYS A CD   1 
ATOM   3808 C CE   . LYS A 1 280 ? -29.364 48.879 -7.626  1.00 26.20 ? 246 LYS A CE   1 
ATOM   3809 N NZ   . LYS A 1 280 ? -30.716 49.487 -7.495  1.00 36.72 ? 246 LYS A NZ   1 
ATOM   3810 H H    . LYS A 1 280 ? -31.591 44.217 -6.585  1.00 23.95 ? 246 LYS A H    1 
ATOM   3811 H HA   . LYS A 1 280 ? -32.712 45.222 -8.729  1.00 22.87 ? 246 LYS A HA   1 
ATOM   3812 H HB2  . LYS A 1 280 ? -30.038 44.913 -7.959  1.00 25.40 ? 246 LYS A HB2  1 
ATOM   3813 H HB3  . LYS A 1 280 ? -30.358 45.366 -9.448  1.00 25.40 ? 246 LYS A HB3  1 
ATOM   3814 H HG2  . LYS A 1 280 ? -31.120 47.361 -8.791  1.00 27.05 ? 246 LYS A HG2  1 
ATOM   3815 H HG3  . LYS A 1 280 ? -31.346 46.872 -7.296  1.00 27.05 ? 246 LYS A HG3  1 
ATOM   3816 H HD2  . LYS A 1 280 ? -29.154 47.015 -6.812  1.00 29.01 ? 246 LYS A HD2  1 
ATOM   3817 H HD3  . LYS A 1 280 ? -28.744 47.068 -8.346  1.00 29.01 ? 246 LYS A HD3  1 
ATOM   3818 H HE2  . LYS A 1 280 ? -28.838 49.152 -6.858  1.00 31.46 ? 246 LYS A HE2  1 
ATOM   3819 H HE3  . LYS A 1 280 ? -28.962 49.218 -8.441  1.00 31.46 ? 246 LYS A HE3  1 
ATOM   3820 H HZ1  . LYS A 1 280 ? -30.643 50.355 -7.309  1.00 44.09 ? 246 LYS A HZ1  1 
ATOM   3821 H HZ2  . LYS A 1 280 ? -31.168 49.392 -8.256  1.00 44.09 ? 246 LYS A HZ2  1 
ATOM   3822 H HZ3  . LYS A 1 280 ? -31.167 49.088 -6.840  1.00 44.09 ? 246 LYS A HZ3  1 
ATOM   3823 N N    . THR A 1 281 ? -31.706 42.240 -9.057  1.00 16.36 ? 247 THR A N    1 
ATOM   3824 C CA   . THR A 1 281 ? -31.808 41.080 -9.935  1.00 19.28 ? 247 THR A CA   1 
ATOM   3825 C C    . THR A 1 281 ? -33.242 40.602 -10.111 1.00 23.05 ? 247 THR A C    1 
ATOM   3826 O O    . THR A 1 281 ? -33.474 39.672 -10.892 1.00 19.46 ? 247 THR A O    1 
ATOM   3827 C CB   . THR A 1 281 ? -30.963 39.917 -9.401  1.00 20.39 ? 247 THR A CB   1 
ATOM   3828 O OG1  . THR A 1 281 ? -31.607 39.341 -8.257  1.00 22.35 ? 247 THR A OG1  1 
ATOM   3829 C CG2  . THR A 1 281 ? -29.564 40.385 -9.022  1.00 21.65 ? 247 THR A CG2  1 
ATOM   3830 H H    . THR A 1 281 ? -31.449 42.054 -8.257  1.00 19.66 ? 247 THR A H    1 
ATOM   3831 H HA   . THR A 1 281 ? -31.454 41.331 -10.802 1.00 23.16 ? 247 THR A HA   1 
ATOM   3832 H HB   . THR A 1 281 ? -30.872 39.243 -10.092 1.00 24.49 ? 247 THR A HB   1 
ATOM   3833 H HG1  . THR A 1 281 ? -31.873 39.948 -7.741  1.00 26.85 ? 247 THR A HG1  1 
ATOM   3834 H HG21 . THR A 1 281 ? -28.982 39.620 -8.892  1.00 26.01 ? 247 THR A HG21 1 
ATOM   3835 H HG22 . THR A 1 281 ? -29.199 40.943 -9.727  1.00 26.01 ? 247 THR A HG22 1 
ATOM   3836 H HG23 . THR A 1 281 ? -29.597 40.899 -8.200  1.00 26.01 ? 247 THR A HG23 1 
ATOM   3837 N N    . GLY A 1 282 ? -34.202 41.206 -9.412  1.00 19.89 ? 248 GLY A N    1 
ATOM   3838 C CA   . GLY A 1 282 ? -35.588 40.795 -9.480  1.00 23.58 ? 248 GLY A CA   1 
ATOM   3839 C C    . GLY A 1 282 ? -36.040 39.894 -8.353  1.00 20.78 ? 248 GLY A C    1 
ATOM   3840 O O    . GLY A 1 282 ? -37.199 39.463 -8.357  1.00 18.30 ? 248 GLY A O    1 
ATOM   3841 H H    . GLY A 1 282 ? -34.065 41.869 -8.882  1.00 23.89 ? 248 GLY A H    1 
ATOM   3842 H HA2  . GLY A 1 282 ? -36.147 41.588 -9.469  1.00 28.33 ? 248 GLY A HA2  1 
ATOM   3843 H HA3  . GLY A 1 282 ? -35.730 40.320 -10.314 1.00 28.33 ? 248 GLY A HA3  1 
ATOM   3844 N N    . LYS A 1 283 ? -35.167 39.595 -7.395  1.00 19.44 ? 249 LYS A N    1 
ATOM   3845 C CA   . LYS A 1 283 ? -35.537 38.745 -6.274  1.00 16.07 ? 249 LYS A CA   1 
ATOM   3846 C C    . LYS A 1 283 ? -36.464 39.475 -5.311  1.00 15.66 ? 249 LYS A C    1 
ATOM   3847 O O    . LYS A 1 283 ? -36.410 40.700 -5.161  1.00 15.10 ? 249 LYS A O    1 
ATOM   3848 C CB   . LYS A 1 283 ? -34.295 38.295 -5.505  1.00 14.51 ? 249 LYS A CB   1 
ATOM   3849 C CG   . LYS A 1 283 ? -33.495 37.195 -6.165  1.00 18.13 ? 249 LYS A CG   1 
ATOM   3850 C CD   . LYS A 1 283 ? -33.903 35.831 -5.638  1.00 17.98 ? 249 LYS A CD   1 
ATOM   3851 C CE   . LYS A 1 283 ? -33.040 34.731 -6.228  1.00 19.35 ? 249 LYS A CE   1 
ATOM   3852 N NZ   . LYS A 1 283 ? -32.933 34.827 -7.710  1.00 23.49 ? 249 LYS A NZ   1 
ATOM   3853 H H    . LYS A 1 283 ? -34.354 39.873 -7.373  1.00 23.35 ? 249 LYS A H    1 
ATOM   3854 H HA   . LYS A 1 283 ? -35.996 37.965 -6.622  1.00 19.31 ? 249 LYS A HA   1 
ATOM   3855 H HB2  . LYS A 1 283 ? -33.706 39.059 -5.400  1.00 17.44 ? 249 LYS A HB2  1 
ATOM   3856 H HB3  . LYS A 1 283 ? -34.574 37.970 -4.635  1.00 17.44 ? 249 LYS A HB3  1 
ATOM   3857 H HG2  . LYS A 1 283 ? -33.651 37.212 -7.122  1.00 21.78 ? 249 LYS A HG2  1 
ATOM   3858 H HG3  . LYS A 1 283 ? -32.552 37.325 -5.979  1.00 21.78 ? 249 LYS A HG3  1 
ATOM   3859 H HD2  . LYS A 1 283 ? -33.802 35.815 -4.673  1.00 21.60 ? 249 LYS A HD2  1 
ATOM   3860 H HD3  . LYS A 1 283 ? -34.827 35.657 -5.877  1.00 21.60 ? 249 LYS A HD3  1 
ATOM   3861 H HE2  . LYS A 1 283 ? -32.146 34.794 -5.857  1.00 23.25 ? 249 LYS A HE2  1 
ATOM   3862 H HE3  . LYS A 1 283 ? -33.430 33.870 -6.010  1.00 23.25 ? 249 LYS A HE3  1 
ATOM   3863 H HZ1  . LYS A 1 283 ? -32.484 34.128 -8.029  1.00 28.21 ? 249 LYS A HZ1  1 
ATOM   3864 H HZ2  . LYS A 1 283 ? -33.745 34.839 -8.074  1.00 28.21 ? 249 LYS A HZ2  1 
ATOM   3865 H HZ3  . LYS A 1 283 ? -32.504 35.574 -7.937  1.00 28.21 ? 249 LYS A HZ3  1 
ATOM   3866 N N    . ILE A 1 284 ? -37.325 38.701 -4.654  1.00 16.56 ? 250 ILE A N    1 
ATOM   3867 C CA   . ILE A 1 284 ? -37.925 39.149 -3.408  1.00 16.31 ? 250 ILE A CA   1 
ATOM   3868 C C    . ILE A 1 284 ? -36.859 39.111 -2.324  1.00 15.12 ? 250 ILE A C    1 
ATOM   3869 O O    . ILE A 1 284 ? -36.061 38.168 -2.248  1.00 17.87 ? 250 ILE A O    1 
ATOM   3870 C CB   . ILE A 1 284 ? -39.122 38.261 -3.027  1.00 14.55 ? 250 ILE A CB   1 
ATOM   3871 C CG1  . ILE A 1 284 ? -40.279 38.440 -4.011  1.00 16.86 ? 250 ILE A CG1  1 
ATOM   3872 C CG2  . ILE A 1 284 ? -39.573 38.552 -1.602  1.00 13.08 ? 250 ILE A CG2  1 
ATOM   3873 C CD1  . ILE A 1 284 ? -41.225 37.252 -4.041  1.00 14.60 ? 250 ILE A CD1  1 
ATOM   3874 H H    . ILE A 1 284 ? -37.574 37.918 -4.908  1.00 19.90 ? 250 ILE A H    1 
ATOM   3875 H HA   . ILE A 1 284 ? -38.253 40.056 -3.514  1.00 19.60 ? 250 ILE A HA   1 
ATOM   3876 H HB   . ILE A 1 284 ? -38.832 37.336 -3.076  1.00 17.48 ? 250 ILE A HB   1 
ATOM   3877 H HG12 . ILE A 1 284 ? -40.791 39.223 -3.755  1.00 20.26 ? 250 ILE A HG12 1 
ATOM   3878 H HG13 . ILE A 1 284 ? -39.917 38.556 -4.903  1.00 20.26 ? 250 ILE A HG13 1 
ATOM   3879 H HG21 . ILE A 1 284 ? -40.469 38.203 -1.477  1.00 15.73 ? 250 ILE A HG21 1 
ATOM   3880 H HG22 . ILE A 1 284 ? -38.961 38.123 -0.983  1.00 15.73 ? 250 ILE A HG22 1 
ATOM   3881 H HG23 . ILE A 1 284 ? -39.569 39.511 -1.460  1.00 15.73 ? 250 ILE A HG23 1 
ATOM   3882 H HD11 . ILE A 1 284 ? -41.897 37.401 -4.725  1.00 17.55 ? 250 ILE A HD11 1 
ATOM   3883 H HD12 . ILE A 1 284 ? -40.719 36.450 -4.244  1.00 17.55 ? 250 ILE A HD12 1 
ATOM   3884 H HD13 . ILE A 1 284 ? -41.650 37.164 -3.173  1.00 17.55 ? 250 ILE A HD13 1 
ATOM   3885 N N    . VAL A 1 285 ? -36.826 40.140 -1.485  1.00 16.28 ? 251 VAL A N    1 
ATOM   3886 C CA   . VAL A 1 285 ? -35.944 40.172 -0.326  1.00 15.10 ? 251 VAL A CA   1 
ATOM   3887 C C    . VAL A 1 285 ? -36.805 40.334 0.916   1.00 17.54 ? 251 VAL A C    1 
ATOM   3888 O O    . VAL A 1 285 ? -37.694 41.194 0.956   1.00 18.61 ? 251 VAL A O    1 
ATOM   3889 C CB   . VAL A 1 285 ? -34.901 41.301 -0.416  1.00 14.27 ? 251 VAL A CB   1 
ATOM   3890 C CG1  . VAL A 1 285 ? -34.035 41.317 0.839   1.00 13.72 ? 251 VAL A CG1  1 
ATOM   3891 C CG2  . VAL A 1 285 ? -34.037 41.133 -1.653  1.00 12.45 ? 251 VAL A CG2  1 
ATOM   3892 H H    . VAL A 1 285 ? -37.313 40.844 -1.569  1.00 19.56 ? 251 VAL A H    1 
ATOM   3893 H HA   . VAL A 1 285 ? -35.466 39.330 -0.269  1.00 18.14 ? 251 VAL A HA   1 
ATOM   3894 H HB   . VAL A 1 285 ? -35.362 42.152 -0.485  1.00 17.15 ? 251 VAL A HB   1 
ATOM   3895 H HG11 . VAL A 1 285 ? -33.314 41.954 0.718   1.00 16.49 ? 251 VAL A HG11 1 
ATOM   3896 H HG12 . VAL A 1 285 ? -34.583 41.578 1.597   1.00 16.49 ? 251 VAL A HG12 1 
ATOM   3897 H HG13 . VAL A 1 285 ? -33.672 40.429 0.984   1.00 16.49 ? 251 VAL A HG13 1 
ATOM   3898 H HG21 . VAL A 1 285 ? -33.421 41.879 -1.713  1.00 14.96 ? 251 VAL A HG21 1 
ATOM   3899 H HG22 . VAL A 1 285 ? -33.542 40.301 -1.582  1.00 14.96 ? 251 VAL A HG22 1 
ATOM   3900 H HG23 . VAL A 1 285 ? -34.608 41.112 -2.437  1.00 14.96 ? 251 VAL A HG23 1 
ATOM   3901 N N    . VAL A 1 286 ? -36.545 39.505 1.919   1.00 14.39 ? 252 VAL A N    1 
ATOM   3902 C CA   . VAL A 1 286 ? -37.210 39.589 3.211   1.00 17.33 ? 252 VAL A CA   1 
ATOM   3903 C C    . VAL A 1 286 ? -36.180 40.093 4.212   1.00 20.75 ? 252 VAL A C    1 
ATOM   3904 O O    . VAL A 1 286 ? -35.206 39.398 4.528   1.00 17.35 ? 252 VAL A O    1 
ATOM   3905 C CB   . VAL A 1 286 ? -37.799 38.240 3.639   1.00 17.31 ? 252 VAL A CB   1 
ATOM   3906 C CG1  . VAL A 1 286 ? -38.345 38.324 5.058   1.00 18.64 ? 252 VAL A CG1  1 
ATOM   3907 C CG2  . VAL A 1 286 ? -38.883 37.800 2.665   1.00 19.61 ? 252 VAL A CG2  1 
ATOM   3908 H H    . VAL A 1 286 ? -35.969 38.868 1.873   1.00 17.29 ? 252 VAL A H    1 
ATOM   3909 H HA   . VAL A 1 286 ? -37.935 40.232 3.165   1.00 20.82 ? 252 VAL A HA   1 
ATOM   3910 H HB   . VAL A 1 286 ? -37.096 37.572 3.628   1.00 20.80 ? 252 VAL A HB   1 
ATOM   3911 H HG11 . VAL A 1 286 ? -38.928 37.566 5.217   1.00 22.39 ? 252 VAL A HG11 1 
ATOM   3912 H HG12 . VAL A 1 286 ? -37.603 38.308 5.683   1.00 22.39 ? 252 VAL A HG12 1 
ATOM   3913 H HG13 . VAL A 1 286 ? -38.842 39.151 5.156   1.00 22.39 ? 252 VAL A HG13 1 
ATOM   3914 H HG21 . VAL A 1 286 ? -39.254 36.955 2.966   1.00 23.56 ? 252 VAL A HG21 1 
ATOM   3915 H HG22 . VAL A 1 286 ? -39.579 38.476 2.640   1.00 23.56 ? 252 VAL A HG22 1 
ATOM   3916 H HG23 . VAL A 1 286 ? -38.493 37.694 1.784   1.00 23.56 ? 252 VAL A HG23 1 
ATOM   3917 N N    . PHE A 1 287 ? -36.398 41.303 4.706   1.00 14.68 ? 253 PHE A N    1 
ATOM   3918 C CA   . PHE A 1 287 ? -35.458 42.002 5.576   1.00 15.83 ? 253 PHE A CA   1 
ATOM   3919 C C    . PHE A 1 287 ? -35.970 41.856 7.006   1.00 16.67 ? 253 PHE A C    1 
ATOM   3920 O O    . PHE A 1 287 ? -36.874 42.579 7.429   1.00 15.85 ? 253 PHE A O    1 
ATOM   3921 C CB   . PHE A 1 287 ? -35.351 43.459 5.137   1.00 15.62 ? 253 PHE A CB   1 
ATOM   3922 C CG   . PHE A 1 287 ? -34.288 44.248 5.847   1.00 14.15 ? 253 PHE A CG   1 
ATOM   3923 C CD1  . PHE A 1 287 ? -34.556 44.868 7.055   1.00 18.97 ? 253 PHE A CD1  1 
ATOM   3924 C CD2  . PHE A 1 287 ? -33.031 44.400 5.287   1.00 15.37 ? 253 PHE A CD2  1 
ATOM   3925 C CE1  . PHE A 1 287 ? -33.583 45.608 7.699   1.00 20.96 ? 253 PHE A CE1  1 
ATOM   3926 C CE2  . PHE A 1 287 ? -32.056 45.138 5.926   1.00 19.45 ? 253 PHE A CE2  1 
ATOM   3927 C CZ   . PHE A 1 287 ? -32.333 45.744 7.131   1.00 16.72 ? 253 PHE A CZ   1 
ATOM   3928 H H    . PHE A 1 287 ? -37.110 41.759 4.546   1.00 17.64 ? 253 PHE A H    1 
ATOM   3929 H HA   . PHE A 1 287 ? -34.576 41.603 5.534   1.00 19.02 ? 253 PHE A HA   1 
ATOM   3930 H HB2  . PHE A 1 287 ? -35.147 43.482 4.189   1.00 18.78 ? 253 PHE A HB2  1 
ATOM   3931 H HB3  . PHE A 1 287 ? -36.200 43.896 5.304   1.00 18.78 ? 253 PHE A HB3  1 
ATOM   3932 H HD1  . PHE A 1 287 ? -35.400 44.785 7.437   1.00 22.79 ? 253 PHE A HD1  1 
ATOM   3933 H HD2  . PHE A 1 287 ? -32.841 43.999 4.469   1.00 18.47 ? 253 PHE A HD2  1 
ATOM   3934 H HE1  . PHE A 1 287 ? -33.770 46.014 8.514   1.00 25.18 ? 253 PHE A HE1  1 
ATOM   3935 H HE2  . PHE A 1 287 ? -31.213 45.227 5.543   1.00 23.37 ? 253 PHE A HE2  1 
ATOM   3936 H HZ   . PHE A 1 287 ? -31.678 46.245 7.562   1.00 20.10 ? 253 PHE A HZ   1 
ATOM   3937 N N    . LYS A 1 288 ? -35.399 40.905 7.745   1.00 11.92 ? 254 LYS A N    1 
ATOM   3938 C CA   . LYS A 1 288 ? -35.858 40.579 9.093   1.00 17.32 ? 254 LYS A CA   1 
ATOM   3939 C C    . LYS A 1 288 ? -35.104 41.438 10.100  1.00 18.50 ? 254 LYS A C    1 
ATOM   3940 O O    . LYS A 1 288 ? -33.891 41.278 10.280  1.00 19.30 ? 254 LYS A O    1 
ATOM   3941 C CB   . LYS A 1 288 ? -35.656 39.094 9.384   1.00 15.17 ? 254 LYS A CB   1 
ATOM   3942 C CG   . LYS A 1 288 ? -36.062 38.660 10.786  1.00 25.08 ? 254 LYS A CG   1 
ATOM   3943 C CD   . LYS A 1 288 ? -37.433 39.189 11.180  1.00 23.15 ? 254 LYS A CD   1 
ATOM   3944 C CE   . LYS A 1 288 ? -37.863 38.655 12.535  1.00 23.08 ? 254 LYS A CE   1 
ATOM   3945 N NZ   . LYS A 1 288 ? -37.378 39.503 13.661  1.00 23.07 ? 254 LYS A NZ   1 
ATOM   3946 H H    . LYS A 1 288 ? -34.733 40.428 7.482   1.00 14.34 ? 254 LYS A H    1 
ATOM   3947 H HA   . LYS A 1 288 ? -36.803 40.785 9.164   1.00 20.81 ? 254 LYS A HA   1 
ATOM   3948 H HB2  . LYS A 1 288 ? -36.187 38.582 8.754   1.00 18.24 ? 254 LYS A HB2  1 
ATOM   3949 H HB3  . LYS A 1 288 ? -34.716 38.884 9.274   1.00 18.24 ? 254 LYS A HB3  1 
ATOM   3950 H HG2  . LYS A 1 288 ? -36.091 37.691 10.823  1.00 30.12 ? 254 LYS A HG2  1 
ATOM   3951 H HG3  . LYS A 1 288 ? -35.414 38.997 11.424  1.00 30.12 ? 254 LYS A HG3  1 
ATOM   3952 H HD2  . LYS A 1 288 ? -37.403 40.157 11.228  1.00 27.80 ? 254 LYS A HD2  1 
ATOM   3953 H HD3  . LYS A 1 288 ? -38.088 38.910 10.520  1.00 27.80 ? 254 LYS A HD3  1 
ATOM   3954 H HE2  . LYS A 1 288 ? -38.831 38.629 12.573  1.00 27.72 ? 254 LYS A HE2  1 
ATOM   3955 H HE3  . LYS A 1 288 ? -37.501 37.763 12.653  1.00 27.72 ? 254 LYS A HE3  1 
ATOM   3956 H HZ1  . LYS A 1 288 ? -37.538 39.097 14.438  1.00 27.72 ? 254 LYS A HZ1  1 
ATOM   3957 H HZ2  . LYS A 1 288 ? -36.503 39.642 13.583  1.00 27.72 ? 254 LYS A HZ2  1 
ATOM   3958 H HZ3  . LYS A 1 288 ? -37.798 40.287 13.654  1.00 27.72 ? 254 LYS A HZ3  1 
ATOM   3959 N N    . ALA A 1 289 ? -35.825 42.333 10.769  1.00 16.70 ? 255 ALA A N    1 
ATOM   3960 C CA   . ALA A 1 289 ? -35.248 43.270 11.721  1.00 16.72 ? 255 ALA A CA   1 
ATOM   3961 C C    . ALA A 1 289 ? -35.694 42.930 13.138  1.00 17.70 ? 255 ALA A C    1 
ATOM   3962 O O    . ALA A 1 289 ? -36.627 42.154 13.359  1.00 19.01 ? 255 ALA A O    1 
ATOM   3963 C CB   . ALA A 1 289 ? -35.639 44.708 11.367  1.00 12.77 ? 255 ALA A CB   1 
ATOM   3964 H H    . ALA A 1 289 ? -36.676 42.417 10.684  1.00 20.07 ? 255 ALA A H    1 
ATOM   3965 H HA   . ALA A 1 289 ? -34.281 43.200 11.687  1.00 20.09 ? 255 ALA A HA   1 
ATOM   3966 H HB1  . ALA A 1 289 ? -35.325 45.301 12.067  1.00 15.35 ? 255 ALA A HB1  1 
ATOM   3967 H HB2  . ALA A 1 289 ? -35.228 44.948 10.522  1.00 15.35 ? 255 ALA A HB2  1 
ATOM   3968 H HB3  . ALA A 1 289 ? -36.604 44.764 11.294  1.00 15.35 ? 255 ALA A HB3  1 
ATOM   3969 N N    . TRP A 1 290 ? -35.010 43.536 14.104  1.00 15.36 ? 256 TRP A N    1 
ATOM   3970 C CA   . TRP A 1 290 ? -35.173 43.214 15.512  1.00 19.47 ? 256 TRP A CA   1 
ATOM   3971 C C    . TRP A 1 290 ? -35.188 44.491 16.337  1.00 21.13 ? 256 TRP A C    1 
ATOM   3972 O O    . TRP A 1 290 ? -34.551 45.483 15.962  1.00 21.43 ? 256 TRP A O    1 
ATOM   3973 C CB   . TRP A 1 290 ? -34.041 42.295 15.998  1.00 14.58 ? 256 TRP A CB   1 
ATOM   3974 C CG   . TRP A 1 290 ? -33.892 41.076 15.148  1.00 17.41 ? 256 TRP A CG   1 
ATOM   3975 C CD1  . TRP A 1 290 ? -33.197 40.972 13.980  1.00 17.69 ? 256 TRP A CD1  1 
ATOM   3976 C CD2  . TRP A 1 290 ? -34.464 39.786 15.393  1.00 18.42 ? 256 TRP A CD2  1 
ATOM   3977 N NE1  . TRP A 1 290 ? -33.300 39.698 13.481  1.00 18.59 ? 256 TRP A NE1  1 
ATOM   3978 C CE2  . TRP A 1 290 ? -34.072 38.949 14.331  1.00 15.07 ? 256 TRP A CE2  1 
ATOM   3979 C CE3  . TRP A 1 290 ? -35.269 39.259 16.407  1.00 23.03 ? 256 TRP A CE3  1 
ATOM   3980 C CZ2  . TRP A 1 290 ? -34.454 37.613 14.254  1.00 18.30 ? 256 TRP A CZ2  1 
ATOM   3981 C CZ3  . TRP A 1 290 ? -35.648 37.932 16.329  1.00 20.24 ? 256 TRP A CZ3  1 
ATOM   3982 C CH2  . TRP A 1 290 ? -35.241 37.124 15.261  1.00 20.67 ? 256 TRP A CH2  1 
ATOM   3983 H H    . TRP A 1 290 ? -34.429 44.154 13.961  1.00 18.46 ? 256 TRP A H    1 
ATOM   3984 H HA   . TRP A 1 290 ? -36.024 42.768 15.650  1.00 23.39 ? 256 TRP A HA   1 
ATOM   3985 H HB2  . TRP A 1 290 ? -33.204 42.784 15.974  1.00 17.52 ? 256 TRP A HB2  1 
ATOM   3986 H HB3  . TRP A 1 290 ? -34.232 42.009 16.905  1.00 17.52 ? 256 TRP A HB3  1 
ATOM   3987 H HD1  . TRP A 1 290 ? -32.723 41.664 13.579  1.00 21.26 ? 256 TRP A HD1  1 
ATOM   3988 H HE1  . TRP A 1 290 ? -32.938 39.415 12.754  1.00 22.33 ? 256 TRP A HE1  1 
ATOM   3989 H HE3  . TRP A 1 290 ? -35.543 39.790 17.119  1.00 27.67 ? 256 TRP A HE3  1 
ATOM   3990 H HZ2  . TRP A 1 290 ? -34.185 37.074 13.547  1.00 21.99 ? 256 TRP A HZ2  1 
ATOM   3991 H HZ3  . TRP A 1 290 ? -36.183 37.570 16.999  1.00 24.32 ? 256 TRP A HZ3  1 
ATOM   3992 H HH2  . TRP A 1 290 ? -35.512 36.235 15.235  1.00 24.83 ? 256 TRP A HH2  1 
ATOM   3993 N N    . PRO A 1 291 ? -35.903 44.497 17.468  1.00 21.37 ? 257 PRO A N    1 
ATOM   3994 C CA   . PRO A 1 291 ? -35.932 45.700 18.309  1.00 23.11 ? 257 PRO A CA   1 
ATOM   3995 C C    . PRO A 1 291 ? -34.690 45.835 19.177  1.00 23.08 ? 257 PRO A C    1 
ATOM   3996 O O    . PRO A 1 291 ? -34.606 45.236 20.253  1.00 22.04 ? 257 PRO A O    1 
ATOM   3997 C CB   . PRO A 1 291 ? -37.195 45.501 19.153  1.00 21.17 ? 257 PRO A CB   1 
ATOM   3998 C CG   . PRO A 1 291 ? -37.326 44.024 19.274  1.00 21.38 ? 257 PRO A CG   1 
ATOM   3999 C CD   . PRO A 1 291 ? -36.761 43.426 18.008  1.00 23.16 ? 257 PRO A CD   1 
ATOM   4000 H HA   . PRO A 1 291 ? -36.028 46.497 17.763  1.00 27.75 ? 257 PRO A HA   1 
ATOM   4001 H HB2  . PRO A 1 291 ? -37.083 45.915 20.023  1.00 25.43 ? 257 PRO A HB2  1 
ATOM   4002 H HB3  . PRO A 1 291 ? -37.962 45.885 18.700  1.00 25.43 ? 257 PRO A HB3  1 
ATOM   4003 H HG2  . PRO A 1 291 ? -36.826 43.718 20.047  1.00 25.68 ? 257 PRO A HG2  1 
ATOM   4004 H HG3  . PRO A 1 291 ? -38.263 43.790 19.371  1.00 25.68 ? 257 PRO A HG3  1 
ATOM   4005 H HD2  . PRO A 1 291 ? -36.238 42.634 18.205  1.00 27.82 ? 257 PRO A HD2  1 
ATOM   4006 H HD3  . PRO A 1 291 ? -37.471 43.208 17.384  1.00 27.82 ? 257 PRO A HD3  1 
ATOM   4007 N N    . ASN A 1 292 ? -33.721 46.617 18.703  1.00 25.09 ? 258 ASN A N    1 
ATOM   4008 C CA   . ASN A 1 292 ? -32.497 46.916 19.447  1.00 24.48 ? 258 ASN A CA   1 
ATOM   4009 C C    . ASN A 1 292 ? -31.851 45.648 19.998  1.00 26.02 ? 258 ASN A C    1 
ATOM   4010 O O    . ASN A 1 292 ? -31.523 45.547 21.183  1.00 25.71 ? 258 ASN A O    1 
ATOM   4011 C CB   . ASN A 1 292 ? -32.775 47.915 20.570  1.00 24.54 ? 258 ASN A CB   1 
ATOM   4012 C CG   . ASN A 1 292 ? -31.510 48.571 21.088  1.00 29.12 ? 258 ASN A CG   1 
ATOM   4013 O OD1  . ASN A 1 292 ? -30.504 48.651 20.382  1.00 32.67 ? 258 ASN A OD1  1 
ATOM   4014 N ND2  . ASN A 1 292 ? -31.551 49.041 22.328  1.00 26.58 ? 258 ASN A ND2  1 
ATOM   4015 H H    . ASN A 1 292 ? -33.750 46.997 17.932  1.00 30.13 ? 258 ASN A H    1 
ATOM   4016 H HA   . ASN A 1 292 ? -31.865 47.317 18.830  1.00 29.40 ? 258 ASN A HA   1 
ATOM   4017 H HB2  . ASN A 1 292 ? -33.361 48.612 20.236  1.00 29.47 ? 258 ASN A HB2  1 
ATOM   4018 H HB3  . ASN A 1 292 ? -33.198 47.451 21.309  1.00 29.47 ? 258 ASN A HB3  1 
ATOM   4019 H HD21 . ASN A 1 292 ? -30.859 49.422 22.667  1.00 31.92 ? 258 ASN A HD21 1 
ATOM   4020 H HD22 . ASN A 1 292 ? -32.271 48.965 22.793  1.00 31.92 ? 258 ASN A HD22 1 
ATOM   4021 N N    . GLU A 1 293 ? -31.663 44.667 19.117  1.00 21.78 ? 259 GLU A N    1 
ATOM   4022 C CA   . GLU A 1 293 ? -30.967 43.418 19.410  1.00 28.27 ? 259 GLU A CA   1 
ATOM   4023 C C    . GLU A 1 293 ? -31.727 42.521 20.378  1.00 22.56 ? 259 GLU A C    1 
ATOM   4024 O O    . GLU A 1 293 ? -31.194 41.485 20.794  1.00 23.36 ? 259 GLU A O    1 
ATOM   4025 C CB   . GLU A 1 293 ? -29.559 43.685 19.958  1.00 22.39 ? 259 GLU A CB   1 
ATOM   4026 C CG   . GLU A 1 293 ? -28.776 44.696 19.133  1.00 26.25 ? 259 GLU A CG   1 
ATOM   4027 C CD   . GLU A 1 293 ? -27.394 44.967 19.684  1.00 27.05 ? 259 GLU A CD   1 
ATOM   4028 O OE1  . GLU A 1 293 ? -27.010 44.332 20.689  1.00 27.06 ? 259 GLU A OE1  1 
ATOM   4029 O OE2  . GLU A 1 293 ? -26.686 45.817 19.102  1.00 29.36 ? 259 GLU A OE2  1 
ATOM   4030 H H    . GLU A 1 293 ? -31.944 44.708 18.305  1.00 26.16 ? 259 GLU A H    1 
ATOM   4031 H HA   . GLU A 1 293 ? -30.884 42.923 18.580  1.00 33.95 ? 259 GLU A HA   1 
ATOM   4032 H HB2  . GLU A 1 293 ? -29.634 44.031 20.861  1.00 26.90 ? 259 GLU A HB2  1 
ATOM   4033 H HB3  . GLU A 1 293 ? -29.061 42.853 19.962  1.00 26.90 ? 259 GLU A HB3  1 
ATOM   4034 H HG2  . GLU A 1 293 ? -28.676 44.356 18.230  1.00 31.53 ? 259 GLU A HG2  1 
ATOM   4035 H HG3  . GLU A 1 293 ? -29.262 45.536 19.120  1.00 31.53 ? 259 GLU A HG3  1 
ATOM   4036 N N    . HIS A 1 294 ? -32.954 42.878 20.746  1.00 20.21 ? 260 HIS A N    1 
ATOM   4037 C CA   . HIS A 1 294 ? -33.769 42.018 21.591  1.00 22.87 ? 260 HIS A CA   1 
ATOM   4038 C C    . HIS A 1 294 ? -34.437 40.932 20.754  1.00 25.63 ? 260 HIS A C    1 
ATOM   4039 O O    . HIS A 1 294 ? -34.772 41.137 19.583  1.00 24.31 ? 260 HIS A O    1 
ATOM   4040 C CB   . HIS A 1 294 ? -34.834 42.833 22.326  1.00 27.78 ? 260 HIS A CB   1 
ATOM   4041 C CG   . HIS A 1 294 ? -34.273 43.872 23.246  1.00 24.35 ? 260 HIS A CG   1 
ATOM   4042 N ND1  . HIS A 1 294 ? -33.290 43.595 24.171  1.00 26.16 ? 260 HIS A ND1  1 
ATOM   4043 C CD2  . HIS A 1 294 ? -34.562 45.188 23.387  1.00 25.50 ? 260 HIS A CD2  1 
ATOM   4044 C CE1  . HIS A 1 294 ? -32.995 44.696 24.839  1.00 27.59 ? 260 HIS A CE1  1 
ATOM   4045 N NE2  . HIS A 1 294 ? -33.753 45.677 24.383  1.00 27.87 ? 260 HIS A NE2  1 
ATOM   4046 H H    . HIS A 1 294 ? -33.337 43.614 20.518  1.00 24.27 ? 260 HIS A H    1 
ATOM   4047 H HA   . HIS A 1 294 ? -33.206 41.592 22.256  1.00 27.47 ? 260 HIS A HA   1 
ATOM   4048 H HB2  . HIS A 1 294 ? -35.387 43.286 21.670  1.00 33.37 ? 260 HIS A HB2  1 
ATOM   4049 H HB3  . HIS A 1 294 ? -35.376 42.229 22.857  1.00 33.37 ? 260 HIS A HB3  1 
ATOM   4050 H HD1  . HIS A 1 294 ? -32.926 42.826 24.294  1.00 31.42 ? 260 HIS A HD1  1 
ATOM   4051 H HD2  . HIS A 1 294 ? -35.191 45.670 22.900  1.00 30.63 ? 260 HIS A HD2  1 
ATOM   4052 H HE1  . HIS A 1 294 ? -32.361 44.768 25.516  1.00 33.14 ? 260 HIS A HE1  1 
ATOM   4053 N N    . SER A 1 295 ? -34.632 39.769 21.368  1.00 22.94 ? 261 SER A N    1 
ATOM   4054 C CA   . SER A 1 295 ? -35.228 38.628 20.685  1.00 22.69 ? 261 SER A CA   1 
ATOM   4055 C C    . SER A 1 295 ? -35.742 37.650 21.733  1.00 25.21 ? 261 SER A C    1 
ATOM   4056 O O    . SER A 1 295 ? -35.609 37.872 22.940  1.00 21.31 ? 261 SER A O    1 
ATOM   4057 C CB   . SER A 1 295 ? -34.222 37.954 19.750  1.00 22.02 ? 261 SER A CB   1 
ATOM   4058 O OG   . SER A 1 295 ? -33.359 37.097 20.475  1.00 20.97 ? 261 SER A OG   1 
ATOM   4059 H H    . SER A 1 295 ? -34.426 39.616 22.189  1.00 27.56 ? 261 SER A H    1 
ATOM   4060 H HA   . SER A 1 295 ? -35.980 38.941 20.159  1.00 27.25 ? 261 SER A HA   1 
ATOM   4061 H HB2  . SER A 1 295 ? -34.704 37.432 19.090  1.00 26.45 ? 261 SER A HB2  1 
ATOM   4062 H HB3  . SER A 1 295 ? -33.692 38.637 19.310  1.00 26.45 ? 261 SER A HB3  1 
ATOM   4063 H HG   . SER A 1 295 ? -33.015 37.513 21.118  1.00 25.19 ? 261 SER A HG   1 
ATOM   4064 N N    . TRP A 1 296 ? -36.323 36.548 21.253  1.00 24.84 ? 262 TRP A N    1 
ATOM   4065 C CA   . TRP A 1 296 ? -36.904 35.556 22.149  1.00 25.71 ? 262 TRP A CA   1 
ATOM   4066 C C    . TRP A 1 296 ? -35.854 34.861 23.007  1.00 24.33 ? 262 TRP A C    1 
ATOM   4067 O O    . TRP A 1 296 ? -36.202 34.307 24.055  1.00 21.55 ? 262 TRP A O    1 
ATOM   4068 C CB   . TRP A 1 296 ? -37.696 34.522 21.342  1.00 21.80 ? 262 TRP A CB   1 
ATOM   4069 C CG   . TRP A 1 296 ? -36.863 33.427 20.741  1.00 24.23 ? 262 TRP A CG   1 
ATOM   4070 C CD1  . TRP A 1 296 ? -36.670 32.174 21.247  1.00 24.34 ? 262 TRP A CD1  1 
ATOM   4071 C CD2  . TRP A 1 296 ? -36.122 33.482 19.514  1.00 24.33 ? 262 TRP A CD2  1 
ATOM   4072 N NE1  . TRP A 1 296 ? -35.853 31.448 20.415  1.00 23.88 ? 262 TRP A NE1  1 
ATOM   4073 C CE2  . TRP A 1 296 ? -35.503 32.227 19.345  1.00 23.98 ? 262 TRP A CE2  1 
ATOM   4074 C CE3  . TRP A 1 296 ? -35.920 34.470 18.546  1.00 28.39 ? 262 TRP A CE3  1 
ATOM   4075 C CZ2  . TRP A 1 296 ? -34.694 31.935 18.247  1.00 25.95 ? 262 TRP A CZ2  1 
ATOM   4076 C CZ3  . TRP A 1 296 ? -35.116 34.177 17.455  1.00 27.17 ? 262 TRP A CZ3  1 
ATOM   4077 C CH2  . TRP A 1 296 ? -34.514 32.920 17.316  1.00 26.70 ? 262 TRP A CH2  1 
ATOM   4078 H H    . TRP A 1 296 ? -36.392 36.355 20.418  1.00 29.84 ? 262 TRP A H    1 
ATOM   4079 H HA   . TRP A 1 296 ? -37.522 36.002 22.749  1.00 30.88 ? 262 TRP A HA   1 
ATOM   4080 H HB2  . TRP A 1 296 ? -38.348 34.106 21.928  1.00 26.19 ? 262 TRP A HB2  1 
ATOM   4081 H HB3  . TRP A 1 296 ? -38.148 34.979 20.615  1.00 26.19 ? 262 TRP A HB3  1 
ATOM   4082 H HD1  . TRP A 1 296 ? -37.038 31.858 22.041  1.00 29.23 ? 262 TRP A HD1  1 
ATOM   4083 H HE1  . TRP A 1 296 ? -35.602 30.635 20.546  1.00 28.68 ? 262 TRP A HE1  1 
ATOM   4084 H HE3  . TRP A 1 296 ? -36.317 35.306 18.631  1.00 34.10 ? 262 TRP A HE3  1 
ATOM   4085 H HZ2  . TRP A 1 296 ? -34.292 31.101 18.152  1.00 31.17 ? 262 TRP A HZ2  1 
ATOM   4086 H HZ3  . TRP A 1 296 ? -34.974 34.827 16.805  1.00 32.64 ? 262 TRP A HZ3  1 
ATOM   4087 H HH2  . TRP A 1 296 ? -33.980 32.752 16.573  1.00 32.07 ? 262 TRP A HH2  1 
ATOM   4088 N N    . ILE A 1 297 ? -34.582 34.879 22.594  1.00 24.47 ? 263 ILE A N    1 
ATOM   4089 C CA   . ILE A 1 297 ? -33.518 34.302 23.413  1.00 25.80 ? 263 ILE A CA   1 
ATOM   4090 C C    . ILE A 1 297 ? -32.982 35.287 24.442  1.00 23.80 ? 263 ILE A C    1 
ATOM   4091 O O    . ILE A 1 297 ? -32.185 34.891 25.306  1.00 30.26 ? 263 ILE A O    1 
ATOM   4092 C CB   . ILE A 1 297 ? -32.359 33.783 22.536  1.00 26.78 ? 263 ILE A CB   1 
ATOM   4093 C CG1  . ILE A 1 297 ? -31.653 34.929 21.809  1.00 31.99 ? 263 ILE A CG1  1 
ATOM   4094 C CG2  . ILE A 1 297 ? -32.869 32.769 21.525  1.00 28.97 ? 263 ILE A CG2  1 
ATOM   4095 C CD1  . ILE A 1 297 ? -30.147 34.887 21.952  1.00 34.71 ? 263 ILE A CD1  1 
ATOM   4096 H H    . ILE A 1 297 ? -34.314 35.217 21.850  1.00 29.39 ? 263 ILE A H    1 
ATOM   4097 H HA   . ILE A 1 297 ? -33.888 33.544 23.892  1.00 30.98 ? 263 ILE A HA   1 
ATOM   4098 H HB   . ILE A 1 297 ? -31.718 33.354 23.126  1.00 32.16 ? 263 ILE A HB   1 
ATOM   4099 H HG12 . ILE A 1 297 ? -31.864 34.880 20.864  1.00 38.41 ? 263 ILE A HG12 1 
ATOM   4100 H HG13 . ILE A 1 297 ? -31.964 35.772 22.175  1.00 38.41 ? 263 ILE A HG13 1 
ATOM   4101 H HG21 . ILE A 1 297 ? -32.122 32.445 20.998  1.00 34.80 ? 263 ILE A HG21 1 
ATOM   4102 H HG22 . ILE A 1 297 ? -33.285 32.032 21.999  1.00 34.80 ? 263 ILE A HG22 1 
ATOM   4103 H HG23 . ILE A 1 297 ? -33.520 33.199 20.948  1.00 34.80 ? 263 ILE A HG23 1 
ATOM   4104 H HD11 . ILE A 1 297 ? -29.764 35.649 21.491  1.00 41.68 ? 263 ILE A HD11 1 
ATOM   4105 H HD12 . ILE A 1 297 ? -29.918 34.921 22.894  1.00 41.68 ? 263 ILE A HD12 1 
ATOM   4106 H HD13 . ILE A 1 297 ? -29.815 34.063 21.561  1.00 41.68 ? 263 ILE A HD13 1 
ATOM   4107 N N    . ASP A 1 298 ? -33.393 36.552 24.379  1.00 26.47 ? 264 ASP A N    1 
ATOM   4108 C CA   . ASP A 1 298 ? -32.995 37.568 25.353  1.00 25.63 ? 264 ASP A CA   1 
ATOM   4109 C C    . ASP A 1 298 ? -33.998 37.515 26.499  1.00 24.96 ? 264 ASP A C    1 
ATOM   4110 O O    . ASP A 1 298 ? -35.069 38.125 26.436  1.00 25.42 ? 264 ASP A O    1 
ATOM   4111 C CB   . ASP A 1 298 ? -32.946 38.943 24.692  1.00 25.59 ? 264 ASP A CB   1 
ATOM   4112 C CG   . ASP A 1 298 ? -32.664 40.068 25.676  1.00 28.36 ? 264 ASP A CG   1 
ATOM   4113 O OD1  . ASP A 1 298 ? -32.562 39.808 26.893  1.00 28.24 ? 264 ASP A OD1  1 
ATOM   4114 O OD2  . ASP A 1 298 ? -32.547 41.226 25.222  1.00 29.32 ? 264 ASP A OD2  1 
ATOM   4115 H H    . ASP A 1 298 ? -33.915 36.854 23.767  1.00 31.79 ? 264 ASP A H    1 
ATOM   4116 H HA   . ASP A 1 298 ? -32.113 37.375 25.706  1.00 30.78 ? 264 ASP A HA   1 
ATOM   4117 H HB2  . ASP A 1 298 ? -32.241 38.946 24.025  1.00 30.73 ? 264 ASP A HB2  1 
ATOM   4118 H HB3  . ASP A 1 298 ? -33.801 39.121 24.272  1.00 30.73 ? 264 ASP A HB3  1 
ATOM   4119 N N    . LYS A 1 299 ? -33.647 36.784 27.560  1.00 26.75 ? 265 LYS A N    1 
ATOM   4120 C CA   . LYS A 1 299 ? -34.606 36.531 28.629  1.00 27.69 ? 265 LYS A CA   1 
ATOM   4121 C C    . LYS A 1 299 ? -34.885 37.784 29.450  1.00 26.94 ? 265 LYS A C    1 
ATOM   4122 O O    . LYS A 1 299 ? -36.006 37.959 29.942  1.00 26.26 ? 265 LYS A O    1 
ATOM   4123 C CB   . LYS A 1 299 ? -34.101 35.401 29.528  1.00 24.88 ? 265 LYS A CB   1 
ATOM   4124 C CG   . LYS A 1 299 ? -34.121 34.010 28.877  1.00 23.38 ? 265 LYS A CG   1 
ATOM   4125 C CD   . LYS A 1 299 ? -35.413 33.750 28.098  1.00 22.70 ? 265 LYS A CD   1 
ATOM   4126 C CE   . LYS A 1 299 ? -35.566 32.290 27.698  1.00 21.76 ? 265 LYS A CE   1 
ATOM   4127 N NZ   . LYS A 1 299 ? -35.500 31.360 28.860  1.00 23.01 ? 265 LYS A NZ   1 
ATOM   4128 H H    . LYS A 1 299 ? -32.872 36.429 27.680  1.00 32.12 ? 265 LYS A H    1 
ATOM   4129 H HA   . LYS A 1 299 ? -35.446 36.248 28.234  1.00 33.26 ? 265 LYS A HA   1 
ATOM   4130 H HB2  . LYS A 1 299 ? -33.184 35.593 29.779  1.00 29.89 ? 265 LYS A HB2  1 
ATOM   4131 H HB3  . LYS A 1 299 ? -34.661 35.362 30.319  1.00 29.89 ? 265 LYS A HB3  1 
ATOM   4132 H HG2  . LYS A 1 299 ? -33.377 33.937 28.259  1.00 28.08 ? 265 LYS A HG2  1 
ATOM   4133 H HG3  . LYS A 1 299 ? -34.046 33.334 29.569  1.00 28.08 ? 265 LYS A HG3  1 
ATOM   4134 H HD2  . LYS A 1 299 ? -36.172 33.992 28.651  1.00 27.27 ? 265 LYS A HD2  1 
ATOM   4135 H HD3  . LYS A 1 299 ? -35.409 34.285 27.289  1.00 27.27 ? 265 LYS A HD3  1 
ATOM   4136 H HE2  . LYS A 1 299 ? -36.427 32.170 27.267  1.00 26.13 ? 265 LYS A HE2  1 
ATOM   4137 H HE3  . LYS A 1 299 ? -34.852 32.054 27.085  1.00 26.13 ? 265 LYS A HE3  1 
ATOM   4138 H HZ1  . LYS A 1 299 ? -35.728 30.539 28.605  1.00 27.63 ? 265 LYS A HZ1  1 
ATOM   4139 H HZ2  . LYS A 1 299 ? -34.674 31.342 29.188  1.00 27.63 ? 265 LYS A HZ2  1 
ATOM   4140 H HZ3  . LYS A 1 299 ? -36.059 31.630 29.498  1.00 27.63 ? 265 LYS A HZ3  1 
ATOM   4141 N N    . ASN A 1 300 ? -33.894 38.664 29.610  1.00 28.92 ? 266 ASN A N    1 
ATOM   4142 C CA   . ASN A 1 300 ? -34.156 39.936 30.276  1.00 29.50 ? 266 ASN A CA   1 
ATOM   4143 C C    . ASN A 1 300 ? -35.260 40.700 29.559  1.00 29.88 ? 266 ASN A C    1 
ATOM   4144 O O    . ASN A 1 300 ? -36.135 41.293 30.199  1.00 28.37 ? 266 ASN A O    1 
ATOM   4145 C CB   . ASN A 1 300 ? -32.882 40.782 30.345  1.00 30.89 ? 266 ASN A CB   1 
ATOM   4146 C CG   . ASN A 1 300 ? -31.641 39.957 30.628  1.00 50.00 ? 266 ASN A CG   1 
ATOM   4147 O OD1  . ASN A 1 300 ? -31.401 38.932 29.988  1.00 51.17 ? 266 ASN A OD1  1 
ATOM   4148 N ND2  . ASN A 1 300 ? -30.842 40.401 31.592  1.00 55.61 ? 266 ASN A ND2  1 
ATOM   4149 H H    . ASN A 1 300 ? -33.082 38.550 29.348  1.00 34.73 ? 266 ASN A H    1 
ATOM   4150 H HA   . ASN A 1 300 ? -34.438 39.757 31.187  1.00 35.43 ? 266 ASN A HA   1 
ATOM   4151 H HB2  . ASN A 1 300 ? -32.755 41.231 29.495  1.00 37.10 ? 266 ASN A HB2  1 
ATOM   4152 H HB3  . ASN A 1 300 ? -32.976 41.436 31.055  1.00 37.10 ? 266 ASN A HB3  1 
ATOM   4153 H HD21 . ASN A 1 300 ? -31.041 41.122 32.017  1.00 66.75 ? 266 ASN A HD21 1 
ATOM   4154 H HD22 . ASN A 1 300 ? -30.126 39.969 31.791  1.00 66.75 ? 266 ASN A HD22 1 
ATOM   4155 N N    . PHE A 1 301 ? -35.240 40.686 28.224  1.00 32.61 ? 267 PHE A N    1 
ATOM   4156 C CA   . PHE A 1 301 ? -36.295 41.338 27.456  1.00 28.06 ? 267 PHE A CA   1 
ATOM   4157 C C    . PHE A 1 301 ? -37.601 40.562 27.551  1.00 25.00 ? 267 PHE A C    1 
ATOM   4158 O O    . PHE A 1 301 ? -38.671 41.147 27.759  1.00 28.35 ? 267 PHE A O    1 
ATOM   4159 C CB   . PHE A 1 301 ? -35.869 41.476 25.994  1.00 25.45 ? 267 PHE A CB   1 
ATOM   4160 C CG   . PHE A 1 301 ? -36.956 41.993 25.098  1.00 22.19 ? 267 PHE A CG   1 
ATOM   4161 C CD1  . PHE A 1 301 ? -37.238 43.346 25.042  1.00 22.00 ? 267 PHE A CD1  1 
ATOM   4162 C CD2  . PHE A 1 301 ? -37.702 41.125 24.319  1.00 23.81 ? 267 PHE A CD2  1 
ATOM   4163 C CE1  . PHE A 1 301 ? -38.240 43.825 24.222  1.00 23.20 ? 267 PHE A CE1  1 
ATOM   4164 C CE2  . PHE A 1 301 ? -38.705 41.597 23.497  1.00 24.59 ? 267 PHE A CE2  1 
ATOM   4165 C CZ   . PHE A 1 301 ? -38.974 42.950 23.448  1.00 23.49 ? 267 PHE A CZ   1 
ATOM   4166 H H    . PHE A 1 301 ? -34.633 40.309 27.746  1.00 39.16 ? 267 PHE A H    1 
ATOM   4167 H HA   . PHE A 1 301 ? -36.439 42.226 27.818  1.00 33.70 ? 267 PHE A HA   1 
ATOM   4168 H HB2  . PHE A 1 301 ? -35.123 42.093 25.943  1.00 30.56 ? 267 PHE A HB2  1 
ATOM   4169 H HB3  . PHE A 1 301 ? -35.602 40.604 25.663  1.00 30.56 ? 267 PHE A HB3  1 
ATOM   4170 H HD1  . PHE A 1 301 ? -36.748 43.940 25.564  1.00 26.43 ? 267 PHE A HD1  1 
ATOM   4171 H HD2  . PHE A 1 301 ? -37.525 40.212 24.350  1.00 28.60 ? 267 PHE A HD2  1 
ATOM   4172 H HE1  . PHE A 1 301 ? -38.419 44.737 24.190  1.00 27.86 ? 267 PHE A HE1  1 
ATOM   4173 H HE2  . PHE A 1 301 ? -39.199 41.005 22.977  1.00 29.54 ? 267 PHE A HE2  1 
ATOM   4174 H HZ   . PHE A 1 301 ? -39.649 43.271 22.895  1.00 28.22 ? 267 PHE A HZ   1 
ATOM   4175 N N    . MET A 1 302 ? -37.535 39.239 27.391  1.00 27.50 ? 268 MET A N    1 
ATOM   4176 C CA   . MET A 1 302 ? -38.744 38.427 27.396  1.00 27.64 ? 268 MET A CA   1 
ATOM   4177 C C    . MET A 1 302 ? -39.415 38.395 28.762  1.00 26.90 ? 268 MET A C    1 
ATOM   4178 O O    . MET A 1 302 ? -40.605 38.072 28.845  1.00 25.60 ? 268 MET A O    1 
ATOM   4179 C CB   . MET A 1 302 ? -38.413 37.006 26.940  1.00 25.88 ? 268 MET A CB   1 
ATOM   4180 C CG   . MET A 1 302 ? -38.022 36.909 25.473  1.00 22.84 ? 268 MET A CG   1 
ATOM   4181 S SD   . MET A 1 302 ? -39.356 37.383 24.359  1.00 21.48 ? 268 MET A SD   1 
ATOM   4182 C CE   . MET A 1 302 ? -40.479 36.002 24.566  1.00 23.47 ? 268 MET A CE   1 
ATOM   4183 H H    . MET A 1 302 ? -36.807 38.794 27.280  1.00 33.03 ? 268 MET A H    1 
ATOM   4184 H HA   . MET A 1 302 ? -39.372 38.803 26.759  1.00 33.20 ? 268 MET A HA   1 
ATOM   4185 H HB2  . MET A 1 302 ? -37.669 36.675 27.468  1.00 31.08 ? 268 MET A HB2  1 
ATOM   4186 H HB3  . MET A 1 302 ? -39.192 36.445 27.077  1.00 31.08 ? 268 MET A HB3  1 
ATOM   4187 H HG2  . MET A 1 302 ? -37.270 37.499 25.307  1.00 27.44 ? 268 MET A HG2  1 
ATOM   4188 H HG3  . MET A 1 302 ? -37.775 35.993 25.272  1.00 27.44 ? 268 MET A HG3  1 
ATOM   4189 H HE1  . MET A 1 302 ? -41.266 36.150 24.018  1.00 28.19 ? 268 MET A HE1  1 
ATOM   4190 H HE2  . MET A 1 302 ? -40.032 35.187 24.291  1.00 28.19 ? 268 MET A HE2  1 
ATOM   4191 H HE3  . MET A 1 302 ? -40.734 35.940 25.500  1.00 28.19 ? 268 MET A HE3  1 
ATOM   4192 N N    . ALA A 1 303 ? -38.686 38.724 29.828  1.00 28.99 ? 269 ALA A N    1 
ATOM   4193 C CA   . ALA A 1 303 ? -39.265 38.761 31.164  1.00 32.32 ? 269 ALA A CA   1 
ATOM   4194 C C    . ALA A 1 303 ? -40.054 40.035 31.436  1.00 34.71 ? 269 ALA A C    1 
ATOM   4195 O O    . ALA A 1 303 ? -40.795 40.083 32.424  1.00 41.88 ? 269 ALA A O    1 
ATOM   4196 C CB   . ALA A 1 303 ? -38.164 38.613 32.218  1.00 30.14 ? 269 ALA A CB   1 
ATOM   4197 H H    . ALA A 1 303 ? -37.851 38.930 29.802  1.00 34.82 ? 269 ALA A H    1 
ATOM   4198 H HA   . ALA A 1 303 ? -39.872 38.010 31.257  1.00 38.81 ? 269 ALA A HA   1 
ATOM   4199 H HB1  . ALA A 1 303 ? -38.562 38.664 33.100  1.00 36.20 ? 269 ALA A HB1  1 
ATOM   4200 H HB2  . ALA A 1 303 ? -37.728 37.755 32.100  1.00 36.20 ? 269 ALA A HB2  1 
ATOM   4201 H HB3  . ALA A 1 303 ? -37.520 39.329 32.104  1.00 36.20 ? 269 ALA A HB3  1 
ATOM   4202 N N    . LYS A 1 304 ? -39.921 41.058 30.593  1.00 30.32 ? 270 LYS A N    1 
ATOM   4203 C CA   . LYS A 1 304 ? -40.628 42.305 30.835  1.00 32.54 ? 270 LYS A CA   1 
ATOM   4204 C C    . LYS A 1 304 ? -42.104 42.166 30.464  1.00 33.46 ? 270 LYS A C    1 
ATOM   4205 O O    . LYS A 1 304 ? -42.461 41.358 29.602  1.00 34.86 ? 270 LYS A O    1 
ATOM   4206 C CB   . LYS A 1 304 ? -40.008 43.440 30.024  1.00 33.30 ? 270 LYS A CB   1 
ATOM   4207 C CG   . LYS A 1 304 ? -38.507 43.602 30.202  1.00 34.49 ? 270 LYS A CG   1 
ATOM   4208 C CD   . LYS A 1 304 ? -37.913 44.449 29.087  1.00 35.67 ? 270 LYS A CD   1 
ATOM   4209 C CE   . LYS A 1 304 ? -36.443 44.741 29.333  1.00 41.73 ? 270 LYS A CE   1 
ATOM   4210 N NZ   . LYS A 1 304 ? -36.252 45.749 30.411  1.00 42.99 ? 270 LYS A NZ   1 
ATOM   4211 H H    . LYS A 1 304 ? -39.433 41.053 29.885  1.00 36.41 ? 270 LYS A H    1 
ATOM   4212 H HA   . LYS A 1 304 ? -40.565 42.532 31.775  1.00 39.07 ? 270 LYS A HA   1 
ATOM   4213 H HB2  . LYS A 1 304 ? -40.174 43.272 29.083  1.00 39.98 ? 270 LYS A HB2  1 
ATOM   4214 H HB3  . LYS A 1 304 ? -40.426 44.273 30.292  1.00 39.98 ? 270 LYS A HB3  1 
ATOM   4215 H HG2  . LYS A 1 304 ? -38.328 44.041 31.049  1.00 41.41 ? 270 LYS A HG2  1 
ATOM   4216 H HG3  . LYS A 1 304 ? -38.083 42.730 30.184  1.00 41.41 ? 270 LYS A HG3  1 
ATOM   4217 H HD2  . LYS A 1 304 ? -37.993 43.973 28.245  1.00 42.83 ? 270 LYS A HD2  1 
ATOM   4218 H HD3  . LYS A 1 304 ? -38.388 45.293 29.037  1.00 42.83 ? 270 LYS A HD3  1 
ATOM   4219 H HE2  . LYS A 1 304 ? -35.994 43.923 29.600  1.00 50.10 ? 270 LYS A HE2  1 
ATOM   4220 H HE3  . LYS A 1 304 ? -36.045 45.087 28.519  1.00 50.10 ? 270 LYS A HE3  1 
ATOM   4221 H HZ1  . LYS A 1 304 ? -35.385 45.920 30.518  1.00 51.62 ? 270 LYS A HZ1  1 
ATOM   4222 H HZ2  . LYS A 1 304 ? -36.671 46.505 30.198  1.00 51.62 ? 270 LYS A HZ2  1 
ATOM   4223 H HZ3  . LYS A 1 304 ? -36.583 45.442 31.178  1.00 51.62 ? 270 LYS A HZ3  1 
ATOM   4224 N N    . PRO A 1 305 ? -42.981 42.943 31.099  1.00 30.80 ? 271 PRO A N    1 
ATOM   4225 C CA   . PRO A 1 305 ? -44.391 42.932 30.694  1.00 35.79 ? 271 PRO A CA   1 
ATOM   4226 C C    . PRO A 1 305 ? -44.542 43.342 29.237  1.00 35.96 ? 271 PRO A C    1 
ATOM   4227 O O    . PRO A 1 305 ? -43.696 44.031 28.662  1.00 36.14 ? 271 PRO A O    1 
ATOM   4228 C CB   . PRO A 1 305 ? -45.060 43.948 31.631  1.00 31.95 ? 271 PRO A CB   1 
ATOM   4229 C CG   . PRO A 1 305 ? -43.982 44.580 32.430  1.00 37.49 ? 271 PRO A CG   1 
ATOM   4230 C CD   . PRO A 1 305 ? -42.719 43.815 32.257  1.00 35.28 ? 271 PRO A CD   1 
ATOM   4231 H HA   . PRO A 1 305 ? -44.785 42.058 30.840  1.00 42.98 ? 271 PRO A HA   1 
ATOM   4232 H HB2  . PRO A 1 305 ? -45.527 44.615 31.103  1.00 38.37 ? 271 PRO A HB2  1 
ATOM   4233 H HB3  . PRO A 1 305 ? -45.686 43.487 32.211  1.00 38.37 ? 271 PRO A HB3  1 
ATOM   4234 H HG2  . PRO A 1 305 ? -43.860 45.492 32.122  1.00 45.01 ? 271 PRO A HG2  1 
ATOM   4235 H HG3  . PRO A 1 305 ? -44.244 44.577 33.364  1.00 45.01 ? 271 PRO A HG3  1 
ATOM   4236 H HD2  . PRO A 1 305 ? -41.979 44.414 32.073  1.00 42.37 ? 271 PRO A HD2  1 
ATOM   4237 H HD3  . PRO A 1 305 ? -42.529 43.286 33.047  1.00 42.37 ? 271 PRO A HD3  1 
ATOM   4238 N N    . LEU A 1 306 ? -45.650 42.903 28.637  1.00 37.19 ? 272 LEU A N    1 
ATOM   4239 C CA   . LEU A 1 306 ? -45.876 43.174 27.221  1.00 37.62 ? 272 LEU A CA   1 
ATOM   4240 C C    . LEU A 1 306 ? -45.874 44.670 26.935  1.00 39.67 ? 272 LEU A C    1 
ATOM   4241 O O    . LEU A 1 306 ? -45.288 45.118 25.942  1.00 33.07 ? 272 LEU A O    1 
ATOM   4242 C CB   . LEU A 1 306 ? -47.197 42.549 26.771  1.00 41.26 ? 272 LEU A CB   1 
ATOM   4243 C CG   . LEU A 1 306 ? -47.422 42.392 25.262  1.00 44.82 ? 272 LEU A CG   1 
ATOM   4244 C CD1  . LEU A 1 306 ? -46.235 41.739 24.556  1.00 47.72 ? 272 LEU A CD1  1 
ATOM   4245 C CD2  . LEU A 1 306 ? -48.693 41.597 25.008  1.00 48.49 ? 272 LEU A CD2  1 
ATOM   4246 H H    . LEU A 1 306 ? -46.275 42.454 29.021  1.00 44.66 ? 272 LEU A H    1 
ATOM   4247 H HA   . LEU A 1 306 ? -45.159 42.768 26.709  1.00 45.18 ? 272 LEU A HA   1 
ATOM   4248 H HB2  . LEU A 1 306 ? -47.253 41.661 27.158  1.00 49.54 ? 272 LEU A HB2  1 
ATOM   4249 H HB3  . LEU A 1 306 ? -47.918 43.104 27.107  1.00 49.54 ? 272 LEU A HB3  1 
ATOM   4250 H HG   . LEU A 1 306 ? -47.515 43.279 24.880  1.00 53.81 ? 272 LEU A HG   1 
ATOM   4251 H HD11 . LEU A 1 306 ? -46.445 41.636 23.615  1.00 57.29 ? 272 LEU A HD11 1 
ATOM   4252 H HD12 . LEU A 1 306 ? -45.455 42.305 24.661  1.00 57.29 ? 272 LEU A HD12 1 
ATOM   4253 H HD13 . LEU A 1 306 ? -46.070 40.870 24.955  1.00 57.29 ? 272 LEU A HD13 1 
ATOM   4254 H HD21 . LEU A 1 306 ? -48.821 41.502 24.051  1.00 58.21 ? 272 LEU A HD21 1 
ATOM   4255 H HD22 . LEU A 1 306 ? -48.606 40.722 25.419  1.00 58.21 ? 272 LEU A HD22 1 
ATOM   4256 H HD23 . LEU A 1 306 ? -49.445 42.071 25.397  1.00 58.21 ? 272 LEU A HD23 1 
ATOM   4257 N N    . GLN A 1 307 ? -46.532 45.459 27.788  1.00 36.90 ? 273 GLN A N    1 
ATOM   4258 C CA   . GLN A 1 307 ? -46.564 46.902 27.573  1.00 38.52 ? 273 GLN A CA   1 
ATOM   4259 C C    . GLN A 1 307 ? -45.158 47.485 27.500  1.00 34.08 ? 273 GLN A C    1 
ATOM   4260 O O    . GLN A 1 307 ? -44.930 48.469 26.786  1.00 34.81 ? 273 GLN A O    1 
ATOM   4261 C CB   . GLN A 1 307 ? -47.364 47.582 28.686  1.00 33.75 ? 273 GLN A CB   1 
ATOM   4262 H H    . GLN A 1 307 ? -46.959 45.188 28.483  1.00 44.30 ? 273 GLN A H    1 
ATOM   4263 H HA   . GLN A 1 307 ? -47.010 47.084 26.731  1.00 46.25 ? 273 GLN A HA   1 
ATOM   4264 N N    . GLU A 1 308 ? -44.205 46.889 28.221  1.00 32.66 ? 274 GLU A N    1 
ATOM   4265 C CA   . GLU A 1 308 ? -42.831 47.375 28.195  1.00 29.88 ? 274 GLU A CA   1 
ATOM   4266 C C    . GLU A 1 308 ? -42.084 46.872 26.966  1.00 33.21 ? 274 GLU A C    1 
ATOM   4267 O O    . GLU A 1 308 ? -41.316 47.623 26.355  1.00 31.35 ? 274 GLU A O    1 
ATOM   4268 C CB   . GLU A 1 308 ? -42.103 46.949 29.470  1.00 32.48 ? 274 GLU A CB   1 
ATOM   4269 C CG   . GLU A 1 308 ? -40.987 47.891 29.887  1.00 44.73 ? 274 GLU A CG   1 
ATOM   4270 C CD   . GLU A 1 308 ? -39.995 47.237 30.830  1.00 48.58 ? 274 GLU A CD   1 
ATOM   4271 O OE1  . GLU A 1 308 ? -40.435 46.509 31.745  1.00 45.72 ? 274 GLU A OE1  1 
ATOM   4272 O OE2  . GLU A 1 308 ? -38.776 47.452 30.658  1.00 47.33 ? 274 GLU A OE2  1 
ATOM   4273 H H    . GLU A 1 308 ? -44.330 46.206 28.728  1.00 39.22 ? 274 GLU A H    1 
ATOM   4274 H HA   . GLU A 1 308 ? -42.842 48.344 28.165  1.00 35.88 ? 274 GLU A HA   1 
ATOM   4275 H HB2  . GLU A 1 308 ? -42.745 46.911 30.196  1.00 39.00 ? 274 GLU A HB2  1 
ATOM   4276 H HB3  . GLU A 1 308 ? -41.712 46.073 29.326  1.00 39.00 ? 274 GLU A HB3  1 
ATOM   4277 H HG2  . GLU A 1 308 ? -40.505 48.180 29.097  1.00 53.70 ? 274 GLU A HG2  1 
ATOM   4278 H HG3  . GLU A 1 308 ? -41.372 48.657 30.340  1.00 53.70 ? 274 GLU A HG3  1 
ATOM   4279 N N    . LYS A 1 309 ? -42.285 45.604 26.599  1.00 32.11 ? 275 LYS A N    1 
ATOM   4280 C CA   . LYS A 1 309 ? -41.725 45.104 25.348  1.00 33.02 ? 275 LYS A CA   1 
ATOM   4281 C C    . LYS A 1 309 ? -42.212 45.934 24.170  1.00 30.25 ? 275 LYS A C    1 
ATOM   4282 O O    . LYS A 1 309 ? -41.471 46.168 23.209  1.00 27.70 ? 275 LYS A O    1 
ATOM   4283 C CB   . LYS A 1 309 ? -42.108 43.638 25.150  1.00 25.10 ? 275 LYS A CB   1 
ATOM   4284 C CG   . LYS A 1 309 ? -41.291 42.655 25.969  1.00 30.50 ? 275 LYS A CG   1 
ATOM   4285 C CD   . LYS A 1 309 ? -41.470 41.226 25.460  1.00 32.96 ? 275 LYS A CD   1 
ATOM   4286 C CE   . LYS A 1 309 ? -42.520 40.464 26.255  1.00 29.65 ? 275 LYS A CE   1 
ATOM   4287 N NZ   . LYS A 1 309 ? -41.908 39.456 27.161  1.00 34.67 ? 275 LYS A NZ   1 
ATOM   4288 H H    . LYS A 1 309 ? -42.733 45.025 27.049  1.00 38.55 ? 275 LYS A H    1 
ATOM   4289 H HA   . LYS A 1 309 ? -40.757 45.161 25.390  1.00 39.65 ? 275 LYS A HA   1 
ATOM   4290 H HB2  . LYS A 1 309 ? -43.038 43.525 25.400  1.00 30.15 ? 275 LYS A HB2  1 
ATOM   4291 H HB3  . LYS A 1 309 ? -41.987 43.411 24.214  1.00 30.15 ? 275 LYS A HB3  1 
ATOM   4292 H HG2  . LYS A 1 309 ? -40.351 42.887 25.907  1.00 36.62 ? 275 LYS A HG2  1 
ATOM   4293 H HG3  . LYS A 1 309 ? -41.581 42.689 26.894  1.00 36.62 ? 275 LYS A HG3  1 
ATOM   4294 H HD2  . LYS A 1 309 ? -41.751 41.251 24.532  1.00 39.58 ? 275 LYS A HD2  1 
ATOM   4295 H HD3  . LYS A 1 309 ? -40.627 40.752 25.538  1.00 39.58 ? 275 LYS A HD3  1 
ATOM   4296 H HE2  . LYS A 1 309 ? -43.027 41.089 26.796  1.00 35.61 ? 275 LYS A HE2  1 
ATOM   4297 H HE3  . LYS A 1 309 ? -43.111 40.001 25.642  1.00 35.61 ? 275 LYS A HE3  1 
ATOM   4298 H HZ1  . LYS A 1 309 ? -42.539 39.066 27.652  1.00 41.64 ? 275 LYS A HZ1  1 
ATOM   4299 H HZ2  . LYS A 1 309 ? -41.487 38.834 26.684  1.00 41.64 ? 275 LYS A HZ2  1 
ATOM   4300 H HZ3  . LYS A 1 309 ? -41.322 39.850 27.703  1.00 41.64 ? 275 LYS A HZ3  1 
ATOM   4301 N N    . ARG A 1 310 ? -43.460 46.392 24.236  1.00 32.67 ? 276 ARG A N    1 
ATOM   4302 C CA   . ARG A 1 310 ? -44.061 47.144 23.144  1.00 29.72 ? 276 ARG A CA   1 
ATOM   4303 C C    . ARG A 1 310 ? -43.590 48.592 23.126  1.00 35.28 ? 276 ARG A C    1 
ATOM   4304 O O    . ARG A 1 310 ? -43.501 49.197 22.051  1.00 32.65 ? 276 ARG A O    1 
ATOM   4305 C CB   . ARG A 1 310 ? -45.583 47.047 23.266  1.00 35.44 ? 276 ARG A CB   1 
ATOM   4306 C CG   . ARG A 1 310 ? -46.394 48.149 22.592  1.00 42.78 ? 276 ARG A CG   1 
ATOM   4307 C CD   . ARG A 1 310 ? -47.890 47.790 22.540  1.00 44.69 ? 276 ARG A CD   1 
ATOM   4308 N NE   . ARG A 1 310 ? -48.109 46.347 22.560  1.00 42.67 ? 276 ARG A NE   1 
ATOM   4309 C CZ   . ARG A 1 310 ? -49.173 45.740 23.070  1.00 51.76 ? 276 ARG A CZ   1 
ATOM   4310 N NH1  . ARG A 1 310 ? -50.175 46.423 23.600  1.00 57.10 ? 276 ARG A NH1  1 
ATOM   4311 N NH2  . ARG A 1 310 ? -49.229 44.411 23.051  1.00 53.58 ? 276 ARG A NH2  1 
ATOM   4312 H H    . ARG A 1 310 ? -43.984 46.280 24.909  1.00 39.23 ? 276 ARG A H    1 
ATOM   4313 H HA   . ARG A 1 310 ? -43.806 46.762 22.289  1.00 35.69 ? 276 ARG A HA   1 
ATOM   4314 H HB2  . ARG A 1 310 ? -45.864 46.206 22.871  1.00 42.55 ? 276 ARG A HB2  1 
ATOM   4315 H HB3  . ARG A 1 310 ? -45.811 47.062 24.208  1.00 42.55 ? 276 ARG A HB3  1 
ATOM   4316 H HG2  . ARG A 1 310 ? -46.294 48.974 23.092  1.00 51.36 ? 276 ARG A HG2  1 
ATOM   4317 H HG3  . ARG A 1 310 ? -46.078 48.273 21.683  1.00 51.36 ? 276 ARG A HG3  1 
ATOM   4318 H HD2  . ARG A 1 310 ? -48.337 48.175 23.311  1.00 53.66 ? 276 ARG A HD2  1 
ATOM   4319 H HD3  . ARG A 1 310 ? -48.275 48.144 21.723  1.00 53.66 ? 276 ARG A HD3  1 
ATOM   4320 H HE   . ARG A 1 310 ? -47.499 45.850 22.212  1.00 51.23 ? 276 ARG A HE   1 
ATOM   4321 H HH11 . ARG A 1 310 ? -50.148 47.282 23.620  1.00 68.54 ? 276 ARG A HH11 1 
ATOM   4322 H HH12 . ARG A 1 310 ? -50.855 46.007 23.925  1.00 68.54 ? 276 ARG A HH12 1 
ATOM   4323 H HH21 . ARG A 1 310 ? -48.582 43.958 22.712  1.00 64.32 ? 276 ARG A HH21 1 
ATOM   4324 H HH22 . ARG A 1 310 ? -49.913 44.005 23.379  1.00 64.32 ? 276 ARG A HH22 1 
ATOM   4325 N N    . LYS A 1 311 ? -43.272 49.159 24.292  1.00 31.34 ? 277 LYS A N    1 
ATOM   4326 C CA   . LYS A 1 311 ? -42.669 50.486 24.321  1.00 33.80 ? 277 LYS A CA   1 
ATOM   4327 C C    . LYS A 1 311 ? -41.249 50.448 23.769  1.00 31.25 ? 277 LYS A C    1 
ATOM   4328 O O    . LYS A 1 311 ? -40.805 51.396 23.111  1.00 32.43 ? 277 LYS A O    1 
ATOM   4329 C CB   . LYS A 1 311 ? -42.677 51.033 25.749  1.00 35.86 ? 277 LYS A CB   1 
ATOM   4330 C CG   . LYS A 1 311 ? -42.079 52.427 25.895  1.00 41.11 ? 277 LYS A CG   1 
ATOM   4331 C CD   . LYS A 1 311 ? -41.067 52.485 27.030  1.00 53.26 ? 277 LYS A CD   1 
ATOM   4332 C CE   . LYS A 1 311 ? -41.747 52.405 28.388  1.00 58.52 ? 277 LYS A CE   1 
ATOM   4333 N NZ   . LYS A 1 311 ? -40.771 52.468 29.512  1.00 51.74 ? 277 LYS A NZ   1 
ATOM   4334 H H    . LYS A 1 311 ? -43.394 48.801 25.064  1.00 37.63 ? 277 LYS A H    1 
ATOM   4335 H HA   . LYS A 1 311 ? -43.193 51.086 23.768  1.00 40.59 ? 277 LYS A HA   1 
ATOM   4336 H HB2  . LYS A 1 311 ? -43.596 51.074 26.059  1.00 43.06 ? 277 LYS A HB2  1 
ATOM   4337 H HB3  . LYS A 1 311 ? -42.164 50.433 26.313  1.00 43.06 ? 277 LYS A HB3  1 
ATOM   4338 H HG2  . LYS A 1 311 ? -41.628 52.670 25.072  1.00 49.35 ? 277 LYS A HG2  1 
ATOM   4339 H HG3  . LYS A 1 311 ? -42.787 53.062 26.086  1.00 49.35 ? 277 LYS A HG3  1 
ATOM   4340 H HD2  . LYS A 1 311 ? -40.453 51.738 26.952  1.00 63.94 ? 277 LYS A HD2  1 
ATOM   4341 H HD3  . LYS A 1 311 ? -40.579 53.322 26.983  1.00 63.94 ? 277 LYS A HD3  1 
ATOM   4342 H HE2  . LYS A 1 311 ? -42.362 53.148 28.480  1.00 70.25 ? 277 LYS A HE2  1 
ATOM   4343 H HE3  . LYS A 1 311 ? -42.229 51.565 28.453  1.00 70.25 ? 277 LYS A HE3  1 
ATOM   4344 H HZ1  . LYS A 1 311 ? -41.203 52.452 30.290  1.00 62.12 ? 277 LYS A HZ1  1 
ATOM   4345 H HZ2  . LYS A 1 311 ? -40.218 51.772 29.474  1.00 62.12 ? 277 LYS A HZ2  1 
ATOM   4346 H HZ3  . LYS A 1 311 ? -40.296 53.219 29.461  1.00 62.12 ? 277 LYS A HZ3  1 
ATOM   4347 N N    . ILE A 1 312 ? -40.524 49.358 24.025  1.00 27.88 ? 278 ILE A N    1 
ATOM   4348 C CA   . ILE A 1 312 ? -39.164 49.232 23.513  1.00 27.02 ? 278 ILE A CA   1 
ATOM   4349 C C    . ILE A 1 312 ? -39.183 49.053 22.000  1.00 29.68 ? 278 ILE A C    1 
ATOM   4350 O O    . ILE A 1 312 ? -38.438 49.717 21.270  1.00 28.29 ? 278 ILE A O    1 
ATOM   4351 C CB   . ILE A 1 312 ? -38.439 48.069 24.214  1.00 26.13 ? 278 ILE A CB   1 
ATOM   4352 C CG1  . ILE A 1 312 ? -38.026 48.479 25.629  1.00 30.17 ? 278 ILE A CG1  1 
ATOM   4353 C CG2  . ILE A 1 312 ? -37.219 47.632 23.417  1.00 26.86 ? 278 ILE A CG2  1 
ATOM   4354 C CD1  . ILE A 1 312 ? -37.772 47.307 26.555  1.00 32.62 ? 278 ILE A CD1  1 
ATOM   4355 H H    . ILE A 1 312 ? -40.795 48.686 24.488  1.00 33.49 ? 278 ILE A H    1 
ATOM   4356 H HA   . ILE A 1 312 ? -38.679 50.049 23.710  1.00 32.45 ? 278 ILE A HA   1 
ATOM   4357 H HB   . ILE A 1 312 ? -39.054 47.320 24.268  1.00 31.38 ? 278 ILE A HB   1 
ATOM   4358 H HG12 . ILE A 1 312 ? -37.209 48.998 25.577  1.00 36.23 ? 278 ILE A HG12 1 
ATOM   4359 H HG13 . ILE A 1 312 ? -38.735 49.015 26.018  1.00 36.23 ? 278 ILE A HG13 1 
ATOM   4360 H HG21 . ILE A 1 312 ? -36.647 47.093 23.986  1.00 32.26 ? 278 ILE A HG21 1 
ATOM   4361 H HG22 . ILE A 1 312 ? -37.511 47.112 22.652  1.00 32.26 ? 278 ILE A HG22 1 
ATOM   4362 H HG23 . ILE A 1 312 ? -36.739 48.420 23.118  1.00 32.26 ? 278 ILE A HG23 1 
ATOM   4363 H HD11 . ILE A 1 312 ? -37.624 47.641 27.453  1.00 39.17 ? 278 ILE A HD11 1 
ATOM   4364 H HD12 . ILE A 1 312 ? -38.545 46.721 26.542  1.00 39.17 ? 278 ILE A HD12 1 
ATOM   4365 H HD13 . ILE A 1 312 ? -36.987 46.827 26.248  1.00 39.17 ? 278 ILE A HD13 1 
ATOM   4366 N N    . ALA A 1 313 ? -40.038 48.156 21.506  1.00 25.18 ? 279 ALA A N    1 
ATOM   4367 C CA   . ALA A 1 313 ? -40.124 47.927 20.068  1.00 25.87 ? 279 ALA A CA   1 
ATOM   4368 C C    . ALA A 1 313 ? -40.522 49.201 19.334  1.00 26.34 ? 279 ALA A C    1 
ATOM   4369 O O    . ALA A 1 313 ? -39.930 49.551 18.306  1.00 24.76 ? 279 ALA A O    1 
ATOM   4370 C CB   . ALA A 1 313 ? -41.120 46.804 19.777  1.00 24.42 ? 279 ALA A CB   1 
ATOM   4371 H H    . ALA A 1 313 ? -40.572 47.673 21.978  1.00 30.25 ? 279 ALA A H    1 
ATOM   4372 H HA   . ALA A 1 313 ? -39.253 47.651 19.742  1.00 31.07 ? 279 ALA A HA   1 
ATOM   4373 H HB1  . ALA A 1 313 ? -41.201 46.695 18.816  1.00 29.33 ? 279 ALA A HB1  1 
ATOM   4374 H HB2  . ALA A 1 313 ? -40.794 45.982 20.176  1.00 29.33 ? 279 ALA A HB2  1 
ATOM   4375 H HB3  . ALA A 1 313 ? -41.981 47.039 20.157  1.00 29.33 ? 279 ALA A HB3  1 
ATOM   4376 N N    . ARG A 1 314 ? -41.531 49.909 19.849  1.00 26.62 ? 280 ARG A N    1 
ATOM   4377 C CA   . ARG A 1 314 ? -41.976 51.142 19.207  1.00 30.63 ? 280 ARG A CA   1 
ATOM   4378 C C    . ARG A 1 314 ? -40.862 52.179 19.172  1.00 25.03 ? 280 ARG A C    1 
ATOM   4379 O O    . ARG A 1 314 ? -40.751 52.952 18.213  1.00 21.69 ? 280 ARG A O    1 
ATOM   4380 C CB   . ARG A 1 314 ? -43.195 51.703 19.939  1.00 26.20 ? 280 ARG A CB   1 
ATOM   4381 C CG   . ARG A 1 314 ? -44.491 50.968 19.654  1.00 33.33 ? 280 ARG A CG   1 
ATOM   4382 C CD   . ARG A 1 314 ? -45.589 51.404 20.614  1.00 45.00 ? 280 ARG A CD   1 
ATOM   4383 N NE   . ARG A 1 314 ? -46.839 50.691 20.377  1.00 53.72 ? 280 ARG A NE   1 
ATOM   4384 C CZ   . ARG A 1 314 ? -47.701 50.989 19.415  1.00 62.61 ? 280 ARG A CZ   1 
ATOM   4385 N NH1  . ARG A 1 314 ? -47.484 51.989 18.575  1.00 48.93 ? 280 ARG A NH1  1 
ATOM   4386 N NH2  . ARG A 1 314 ? -48.810 50.265 19.291  1.00 63.16 ? 280 ARG A NH2  1 
ATOM   4387 H H    . ARG A 1 314 ? -41.968 49.698 20.560  1.00 31.97 ? 280 ARG A H    1 
ATOM   4388 H HA   . ARG A 1 314 ? -42.234 50.940 18.293  1.00 36.79 ? 280 ARG A HA   1 
ATOM   4389 H HB2  . ARG A 1 314 ? -43.033 51.653 20.894  1.00 31.46 ? 280 ARG A HB2  1 
ATOM   4390 H HB3  . ARG A 1 314 ? -43.317 52.628 19.671  1.00 31.46 ? 280 ARG A HB3  1 
ATOM   4391 H HG2  . ARG A 1 314 ? -44.781 51.162 18.749  1.00 40.02 ? 280 ARG A HG2  1 
ATOM   4392 H HG3  . ARG A 1 314 ? -44.352 50.014 19.761  1.00 40.02 ? 280 ARG A HG3  1 
ATOM   4393 H HD2  . ARG A 1 314 ? -45.306 51.224 21.524  1.00 54.02 ? 280 ARG A HD2  1 
ATOM   4394 H HD3  . ARG A 1 314 ? -45.755 52.352 20.499  1.00 54.02 ? 280 ARG A HD3  1 
ATOM   4395 H HE   . ARG A 1 314 ? -47.029 50.033 20.897  1.00 64.49 ? 280 ARG A HE   1 
ATOM   4396 H HH11 . ARG A 1 314 ? -46.770 52.463 18.647  1.00 58.74 ? 280 ARG A HH11 1 
ATOM   4397 H HH12 . ARG A 1 314 ? -48.057 52.164 17.958  1.00 58.74 ? 280 ARG A HH12 1 
ATOM   4398 H HH21 . ARG A 1 314 ? -48.961 49.613 19.832  1.00 75.82 ? 280 ARG A HH21 1 
ATOM   4399 H HH22 . ARG A 1 314 ? -49.377 50.448 18.671  1.00 75.82 ? 280 ARG A HH22 1 
ATOM   4400 N N    . ALA A 1 315 ? -40.028 52.213 20.212  1.00 25.71 ? 281 ALA A N    1 
ATOM   4401 C CA   . ALA A 1 315 ? -38.993 53.231 20.320  1.00 26.41 ? 281 ALA A CA   1 
ATOM   4402 C C    . ALA A 1 315 ? -37.771 52.935 19.462  1.00 26.61 ? 281 ALA A C    1 
ATOM   4403 O O    . ALA A 1 315 ? -36.966 53.842 19.226  1.00 22.97 ? 281 ALA A O    1 
ATOM   4404 C CB   . ALA A 1 315 ? -38.558 53.379 21.780  1.00 25.83 ? 281 ALA A CB   1 
ATOM   4405 H H    . ALA A 1 315 ? -40.044 51.656 20.867  1.00 30.88 ? 281 ALA A H    1 
ATOM   4406 H HA   . ALA A 1 315 ? -39.364 54.077 20.023  1.00 31.72 ? 281 ALA A HA   1 
ATOM   4407 H HB1  . ALA A 1 315 ? -37.883 54.073 21.840  1.00 31.03 ? 281 ALA A HB1  1 
ATOM   4408 H HB2  . ALA A 1 315 ? -39.329 53.619 22.317  1.00 31.03 ? 281 ALA A HB2  1 
ATOM   4409 H HB3  . ALA A 1 315 ? -38.191 52.534 22.087  1.00 31.03 ? 281 ALA A HB3  1 
ATOM   4410 N N    . ASN A 1 316 ? -37.614 51.698 18.984  1.00 24.71 ? 282 ASN A N    1 
ATOM   4411 C CA   . ASN A 1 316 ? -36.389 51.274 18.317  1.00 20.50 ? 282 ASN A CA   1 
ATOM   4412 C C    . ASN A 1 316 ? -36.625 50.823 16.879  1.00 19.44 ? 282 ASN A C    1 
ATOM   4413 O O    . ASN A 1 316 ? -35.753 50.180 16.287  1.00 19.20 ? 282 ASN A O    1 
ATOM   4414 C CB   . ASN A 1 316 ? -35.722 50.157 19.120  1.00 26.03 ? 282 ASN A CB   1 
ATOM   4415 C CG   . ASN A 1 316 ? -35.095 50.662 20.403  1.00 29.57 ? 282 ASN A CG   1 
ATOM   4416 O OD1  . ASN A 1 316 ? -33.995 51.213 20.393  1.00 22.84 ? 282 ASN A OD1  1 
ATOM   4417 N ND2  . ASN A 1 316 ? -35.797 50.485 21.517  1.00 31.07 ? 282 ASN A ND2  1 
ATOM   4418 H H    . ASN A 1 316 ? -38.213 51.082 19.035  1.00 29.68 ? 282 ASN A H    1 
ATOM   4419 H HA   . ASN A 1 316 ? -35.784 52.032 18.277  1.00 24.63 ? 282 ASN A HA   1 
ATOM   4420 H HB2  . ASN A 1 316 ? -36.389 49.492 19.353  1.00 31.27 ? 282 ASN A HB2  1 
ATOM   4421 H HB3  . ASN A 1 316 ? -35.024 49.752 18.582  1.00 31.27 ? 282 ASN A HB3  1 
ATOM   4422 H HD21 . ASN A 1 316 ? -35.484 50.755 22.271  1.00 37.32 ? 282 ASN A HD21 1 
ATOM   4423 H HD22 . ASN A 1 316 ? -36.566 50.101 21.484  1.00 37.32 ? 282 ASN A HD22 1 
ATOM   4424 N N    . ILE A 1 317 ? -37.779 51.155 16.298  1.00 20.77 ? 283 ILE A N    1 
ATOM   4425 C CA   . ILE A 1 317 ? -38.057 50.754 14.922  1.00 17.90 ? 283 ILE A CA   1 
ATOM   4426 C C    . ILE A 1 317 ? -37.357 51.647 13.905  1.00 23.86 ? 283 ILE A C    1 
ATOM   4427 O O    . ILE A 1 317 ? -37.129 51.214 12.768  1.00 19.77 ? 283 ILE A O    1 
ATOM   4428 C CB   . ILE A 1 317 ? -39.573 50.756 14.656  1.00 20.08 ? 283 ILE A CB   1 
ATOM   4429 C CG1  . ILE A 1 317 ? -39.890 50.023 13.351  1.00 23.60 ? 283 ILE A CG1  1 
ATOM   4430 C CG2  . ILE A 1 317 ? -40.111 52.182 14.610  1.00 21.07 ? 283 ILE A CG2  1 
ATOM   4431 C CD1  . ILE A 1 317 ? -41.375 49.880 13.075  1.00 25.84 ? 283 ILE A CD1  1 
ATOM   4432 H H    . ILE A 1 317 ? -38.408 51.606 16.674  1.00 24.95 ? 283 ILE A H    1 
ATOM   4433 H HA   . ILE A 1 317 ? -37.722 49.852 14.803  1.00 21.51 ? 283 ILE A HA   1 
ATOM   4434 H HB   . ILE A 1 317 ? -40.007 50.287 15.387  1.00 24.12 ? 283 ILE A HB   1 
ATOM   4435 H HG12 . ILE A 1 317 ? -39.499 50.516 12.613  1.00 28.35 ? 283 ILE A HG12 1 
ATOM   4436 H HG13 . ILE A 1 317 ? -39.510 49.132 13.393  1.00 28.35 ? 283 ILE A HG13 1 
ATOM   4437 H HG21 . ILE A 1 317 ? -41.078 52.157 14.672  1.00 25.31 ? 283 ILE A HG21 1 
ATOM   4438 H HG22 . ILE A 1 317 ? -39.744 52.682 15.356  1.00 25.31 ? 283 ILE A HG22 1 
ATOM   4439 H HG23 . ILE A 1 317 ? -39.844 52.593 13.773  1.00 25.31 ? 283 ILE A HG23 1 
ATOM   4440 H HD11 . ILE A 1 317 ? -41.499 49.320 12.293  1.00 31.03 ? 283 ILE A HD11 1 
ATOM   4441 H HD12 . ILE A 1 317 ? -41.802 49.471 13.845  1.00 31.03 ? 283 ILE A HD12 1 
ATOM   4442 H HD13 . ILE A 1 317 ? -41.753 50.759 12.916  1.00 31.03 ? 283 ILE A HD13 1 
ATOM   4443 N N    . THR A 1 318 ? -36.993 52.875 14.283  1.00 20.47 ? 284 THR A N    1 
ATOM   4444 C CA   . THR A 1 318 ? -36.513 53.843 13.301  1.00 23.73 ? 284 THR A CA   1 
ATOM   4445 C C    . THR A 1 318 ? -35.244 53.358 12.608  1.00 17.47 ? 284 THR A C    1 
ATOM   4446 O O    . THR A 1 318 ? -35.159 53.365 11.374  1.00 24.43 ? 284 THR A O    1 
ATOM   4447 C CB   . THR A 1 318 ? -36.273 55.197 13.969  1.00 21.37 ? 284 THR A CB   1 
ATOM   4448 O OG1  . THR A 1 318 ? -37.390 55.525 14.805  1.00 26.15 ? 284 THR A OG1  1 
ATOM   4449 C CG2  . THR A 1 318 ? -36.095 56.282 12.915  1.00 21.13 ? 284 THR A CG2  1 
ATOM   4450 H H    . THR A 1 318 ? -37.014 53.167 15.092  1.00 24.60 ? 284 THR A H    1 
ATOM   4451 H HA   . THR A 1 318 ? -37.199 53.953 12.624  1.00 28.50 ? 284 THR A HA   1 
ATOM   4452 H HB   . THR A 1 318 ? -35.468 55.156 14.508  1.00 25.67 ? 284 THR A HB   1 
ATOM   4453 H HG1  . THR A 1 318 ? -38.093 55.553 14.347  1.00 31.41 ? 284 THR A HG1  1 
ATOM   4454 H HG21 . THR A 1 318 ? -36.074 57.155 13.338  1.00 25.38 ? 284 THR A HG21 1 
ATOM   4455 H HG22 . THR A 1 318 ? -35.263 56.145 12.436  1.00 25.38 ? 284 THR A HG22 1 
ATOM   4456 H HG23 . THR A 1 318 ? -36.831 56.256 12.284  1.00 25.38 ? 284 THR A HG23 1 
ATOM   4457 N N    . PHE A 1 319 ? -34.240 52.939 13.381  1.00 19.12 ? 285 PHE A N    1 
ATOM   4458 C CA   . PHE A 1 319 ? -32.976 52.538 12.765  1.00 23.36 ? 285 PHE A CA   1 
ATOM   4459 C C    . PHE A 1 319 ? -33.148 51.367 11.808  1.00 17.50 ? 285 PHE A C    1 
ATOM   4460 O O    . PHE A 1 319 ? -32.751 51.485 10.636  1.00 16.53 ? 285 PHE A O    1 
ATOM   4461 C CB   . PHE A 1 319 ? -31.935 52.221 13.840  1.00 18.37 ? 285 PHE A CB   1 
ATOM   4462 C CG   . PHE A 1 319 ? -30.635 51.729 13.273  1.00 19.48 ? 285 PHE A CG   1 
ATOM   4463 C CD1  . PHE A 1 319 ? -29.743 52.616 12.695  1.00 22.12 ? 285 PHE A CD1  1 
ATOM   4464 C CD2  . PHE A 1 319 ? -30.319 50.381 13.285  1.00 17.21 ? 285 PHE A CD2  1 
ATOM   4465 C CE1  . PHE A 1 319 ? -28.554 52.170 12.154  1.00 21.05 ? 285 PHE A CE1  1 
ATOM   4466 C CE2  . PHE A 1 319 ? -29.126 49.929 12.749  1.00 17.90 ? 285 PHE A CE2  1 
ATOM   4467 C CZ   . PHE A 1 319 ? -28.244 50.825 12.184  1.00 22.20 ? 285 PHE A CZ   1 
ATOM   4468 H H    . PHE A 1 319 ? -34.265 52.879 14.239  1.00 22.98 ? 285 PHE A H    1 
ATOM   4469 H HA   . PHE A 1 319 ? -32.661 53.305 12.262  1.00 28.06 ? 285 PHE A HA   1 
ATOM   4470 H HB2  . PHE A 1 319 ? -31.754 53.026 14.350  1.00 22.07 ? 285 PHE A HB2  1 
ATOM   4471 H HB3  . PHE A 1 319 ? -32.287 51.530 14.424  1.00 22.07 ? 285 PHE A HB3  1 
ATOM   4472 H HD1  . PHE A 1 319 ? -29.947 53.523 12.671  1.00 26.57 ? 285 PHE A HD1  1 
ATOM   4473 H HD2  . PHE A 1 319 ? -30.916 49.772 13.658  1.00 20.68 ? 285 PHE A HD2  1 
ATOM   4474 H HE1  . PHE A 1 319 ? -27.962 52.775 11.769  1.00 25.29 ? 285 PHE A HE1  1 
ATOM   4475 H HE2  . PHE A 1 319 ? -28.920 49.022 12.770  1.00 21.51 ? 285 PHE A HE2  1 
ATOM   4476 H HZ   . PHE A 1 319 ? -27.441 50.523 11.823  1.00 26.67 ? 285 PHE A HZ   1 
ATOM   4477 N N    . PRO A 1 320 ? -33.705 50.222 12.221  1.00 19.53 ? 286 PRO A N    1 
ATOM   4478 C CA   . PRO A 1 320 ? -33.868 49.121 11.256  1.00 16.34 ? 286 PRO A CA   1 
ATOM   4479 C C    . PRO A 1 320 ? -34.779 49.474 10.095  1.00 18.06 ? 286 PRO A C    1 
ATOM   4480 O O    . PRO A 1 320 ? -34.535 49.027 8.967   1.00 15.98 ? 286 PRO A O    1 
ATOM   4481 C CB   . PRO A 1 320 ? -34.443 47.981 12.113  1.00 18.90 ? 286 PRO A CB   1 
ATOM   4482 C CG   . PRO A 1 320 ? -35.003 48.646 13.326  1.00 15.67 ? 286 PRO A CG   1 
ATOM   4483 C CD   . PRO A 1 320 ? -34.124 49.829 13.577  1.00 16.78 ? 286 PRO A CD   1 
ATOM   4484 H HA   . PRO A 1 320 ? -33.000 48.854 10.914  1.00 19.63 ? 286 PRO A HA   1 
ATOM   4485 H HB2  . PRO A 1 320 ? -35.138 47.518 11.620  1.00 22.71 ? 286 PRO A HB2  1 
ATOM   4486 H HB3  . PRO A 1 320 ? -33.737 47.361 12.353  1.00 22.71 ? 286 PRO A HB3  1 
ATOM   4487 H HG2  . PRO A 1 320 ? -35.916 48.925 13.155  1.00 18.83 ? 286 PRO A HG2  1 
ATOM   4488 H HG3  . PRO A 1 320 ? -34.978 48.033 14.077  1.00 18.83 ? 286 PRO A HG3  1 
ATOM   4489 H HD2  . PRO A 1 320 ? -34.620 50.544 14.007  1.00 20.17 ? 286 PRO A HD2  1 
ATOM   4490 H HD3  . PRO A 1 320 ? -33.358 49.584 14.119  1.00 20.17 ? 286 PRO A HD3  1 
ATOM   4491 N N    . LEU A 1 321 ? -35.828 50.265 10.335  1.00 16.94 ? 287 LEU A N    1 
ATOM   4492 C CA   . LEU A 1 321 ? -36.706 50.660 9.238   1.00 15.48 ? 287 LEU A CA   1 
ATOM   4493 C C    . LEU A 1 321 ? -35.977 51.563 8.251   1.00 15.21 ? 287 LEU A C    1 
ATOM   4494 O O    . LEU A 1 321 ? -36.137 51.418 7.034   1.00 14.54 ? 287 LEU A O    1 
ATOM   4495 C CB   . LEU A 1 321 ? -37.954 51.360 9.778   1.00 16.07 ? 287 LEU A CB   1 
ATOM   4496 C CG   . LEU A 1 321 ? -38.933 51.868 8.712   1.00 17.76 ? 287 LEU A CG   1 
ATOM   4497 C CD1  . LEU A 1 321 ? -39.404 50.737 7.804   1.00 14.66 ? 287 LEU A CD1  1 
ATOM   4498 C CD2  . LEU A 1 321 ? -40.124 52.562 9.355   1.00 16.56 ? 287 LEU A CD2  1 
ATOM   4499 H H    . LEU A 1 321 ? -36.046 50.579 11.106  1.00 20.36 ? 287 LEU A H    1 
ATOM   4500 H HA   . LEU A 1 321 ? -36.992 49.861 8.769   1.00 18.60 ? 287 LEU A HA   1 
ATOM   4501 H HB2  . LEU A 1 321 ? -38.436 50.733 10.340  1.00 19.31 ? 287 LEU A HB2  1 
ATOM   4502 H HB3  . LEU A 1 321 ? -37.672 52.126 10.302  1.00 19.31 ? 287 LEU A HB3  1 
ATOM   4503 H HG   . LEU A 1 321 ? -38.467 52.515 8.160   1.00 21.34 ? 287 LEU A HG   1 
ATOM   4504 H HD11 . LEU A 1 321 ? -40.007 51.099 7.136   1.00 17.62 ? 287 LEU A HD11 1 
ATOM   4505 H HD12 . LEU A 1 321 ? -38.633 50.338 7.371   1.00 17.62 ? 287 LEU A HD12 1 
ATOM   4506 H HD13 . LEU A 1 321 ? -39.864 50.072 8.339   1.00 17.62 ? 287 LEU A HD13 1 
ATOM   4507 H HD21 . LEU A 1 321 ? -40.764 52.795 8.664   1.00 19.90 ? 287 LEU A HD21 1 
ATOM   4508 H HD22 . LEU A 1 321 ? -40.533 51.960 9.995   1.00 19.90 ? 287 LEU A HD22 1 
ATOM   4509 H HD23 . LEU A 1 321 ? -39.816 53.365 9.805   1.00 19.90 ? 287 LEU A HD23 1 
ATOM   4510 N N    . ALA A 1 322 ? -35.180 52.508 8.755   1.00 16.25 ? 288 ALA A N    1 
ATOM   4511 C CA   . ALA A 1 322 ? -34.401 53.358 7.862   1.00 19.07 ? 288 ALA A CA   1 
ATOM   4512 C C    . ALA A 1 322 ? -33.378 52.537 7.089   1.00 16.91 ? 288 ALA A C    1 
ATOM   4513 O O    . ALA A 1 322 ? -33.171 52.756 5.889   1.00 18.33 ? 288 ALA A O    1 
ATOM   4514 C CB   . ALA A 1 322 ? -33.713 54.464 8.658   1.00 15.46 ? 288 ALA A CB   1 
ATOM   4515 H H    . ALA A 1 322 ? -35.076 52.672 9.593   1.00 19.53 ? 288 ALA A H    1 
ATOM   4516 H HA   . ALA A 1 322 ? -34.998 53.779 7.224   1.00 22.91 ? 288 ALA A HA   1 
ATOM   4517 H HB1  . ALA A 1 322 ? -33.210 55.026 8.048   1.00 18.58 ? 288 ALA A HB1  1 
ATOM   4518 H HB2  . ALA A 1 322 ? -34.387 54.992 9.114   1.00 18.58 ? 288 ALA A HB2  1 
ATOM   4519 H HB3  . ALA A 1 322 ? -33.114 54.062 9.307   1.00 18.58 ? 288 ALA A HB3  1 
ATOM   4520 N N    . ALA A 1 323 ? -32.731 51.581 7.759   1.00 15.48 ? 289 ALA A N    1 
ATOM   4521 C CA   . ALA A 1 323 ? -31.817 50.684 7.064   1.00 18.51 ? 289 ALA A CA   1 
ATOM   4522 C C    . ALA A 1 323 ? -32.535 49.944 5.945   1.00 19.07 ? 289 ALA A C    1 
ATOM   4523 O O    . ALA A 1 323 ? -32.053 49.893 4.807   1.00 16.96 ? 289 ALA A O    1 
ATOM   4524 C CB   . ALA A 1 323 ? -31.199 49.698 8.052   1.00 20.02 ? 289 ALA A CB   1 
ATOM   4525 H H    . ALA A 1 323 ? -32.805 51.435 8.603   1.00 18.60 ? 289 ALA A H    1 
ATOM   4526 H HA   . ALA A 1 323 ? -31.098 51.206 6.673   1.00 22.24 ? 289 ALA A HA   1 
ATOM   4527 H HB1  . ALA A 1 323 ? -30.609 49.096 7.571   1.00 24.05 ? 289 ALA A HB1  1 
ATOM   4528 H HB2  . ALA A 1 323 ? -30.695 50.192 8.718   1.00 24.05 ? 289 ALA A HB2  1 
ATOM   4529 H HB3  . ALA A 1 323 ? -31.908 49.194 8.480   1.00 24.05 ? 289 ALA A HB3  1 
ATOM   4530 N N    . PHE A 1 324 ? -33.698 49.363 6.251   1.00 16.44 ? 290 PHE A N    1 
ATOM   4531 C CA   . PHE A 1 324 ? -34.482 48.697 5.219   1.00 18.14 ? 290 PHE A CA   1 
ATOM   4532 C C    . PHE A 1 324 ? -34.774 49.645 4.063   1.00 15.33 ? 290 PHE A C    1 
ATOM   4533 O O    . PHE A 1 324 ? -34.489 49.334 2.901   1.00 13.26 ? 290 PHE A O    1 
ATOM   4534 C CB   . PHE A 1 324 ? -35.790 48.164 5.806   1.00 12.93 ? 290 PHE A CB   1 
ATOM   4535 C CG   . PHE A 1 324 ? -36.731 47.618 4.771   1.00 15.74 ? 290 PHE A CG   1 
ATOM   4536 C CD1  . PHE A 1 324 ? -36.464 46.412 4.142   1.00 15.38 ? 290 PHE A CD1  1 
ATOM   4537 C CD2  . PHE A 1 324 ? -37.869 48.318 4.410   1.00 17.42 ? 290 PHE A CD2  1 
ATOM   4538 C CE1  . PHE A 1 324 ? -37.321 45.909 3.185   1.00 17.50 ? 290 PHE A CE1  1 
ATOM   4539 C CE2  . PHE A 1 324 ? -38.730 47.820 3.448   1.00 17.25 ? 290 PHE A CE2  1 
ATOM   4540 C CZ   . PHE A 1 324 ? -38.455 46.614 2.836   1.00 14.38 ? 290 PHE A CZ   1 
ATOM   4541 H H    . PHE A 1 324 ? -34.046 49.342 7.037   1.00 19.75 ? 290 PHE A H    1 
ATOM   4542 H HA   . PHE A 1 324 ? -33.973 47.943 4.882   1.00 21.79 ? 290 PHE A HA   1 
ATOM   4543 H HB2  . PHE A 1 324 ? -35.585 47.449 6.428   1.00 15.55 ? 290 PHE A HB2  1 
ATOM   4544 H HB3  . PHE A 1 324 ? -36.243 48.886 6.268   1.00 15.55 ? 290 PHE A HB3  1 
ATOM   4545 H HD1  . PHE A 1 324 ? -35.697 45.936 4.368   1.00 18.48 ? 290 PHE A HD1  1 
ATOM   4546 H HD2  . PHE A 1 324 ? -38.057 49.131 4.818   1.00 20.93 ? 290 PHE A HD2  1 
ATOM   4547 H HE1  . PHE A 1 324 ? -37.135 45.095 2.775   1.00 21.03 ? 290 PHE A HE1  1 
ATOM   4548 H HE2  . PHE A 1 324 ? -39.493 48.298 3.215   1.00 20.73 ? 290 PHE A HE2  1 
ATOM   4549 H HZ   . PHE A 1 324 ? -39.033 46.277 2.190   1.00 17.28 ? 290 PHE A HZ   1 
ATOM   4550 N N    . LEU A 1 325 ? -35.339 50.816 4.370   1.00 17.48 ? 291 LEU A N    1 
ATOM   4551 C CA   . LEU A 1 325 ? -35.734 51.745 3.317   1.00 20.04 ? 291 LEU A CA   1 
ATOM   4552 C C    . LEU A 1 325 ? -34.532 52.262 2.540   1.00 17.73 ? 291 LEU A C    1 
ATOM   4553 O O    . LEU A 1 325 ? -34.658 52.594 1.355   1.00 14.95 ? 291 LEU A O    1 
ATOM   4554 C CB   . LEU A 1 325 ? -36.510 52.916 3.919   1.00 19.06 ? 291 LEU A CB   1 
ATOM   4555 C CG   . LEU A 1 325 ? -37.887 52.599 4.504   1.00 15.95 ? 291 LEU A CG   1 
ATOM   4556 C CD1  . LEU A 1 325 ? -38.543 53.864 5.032   1.00 18.06 ? 291 LEU A CD1  1 
ATOM   4557 C CD2  . LEU A 1 325 ? -38.766 51.930 3.465   1.00 17.76 ? 291 LEU A CD2  1 
ATOM   4558 H H    . LEU A 1 325 ? -35.501 51.090 5.168   1.00 21.00 ? 291 LEU A H    1 
ATOM   4559 H HA   . LEU A 1 325 ? -36.315 51.279 2.696   1.00 24.08 ? 291 LEU A HA   1 
ATOM   4560 H HB2  . LEU A 1 325 ? -35.977 53.292 4.637   1.00 22.90 ? 291 LEU A HB2  1 
ATOM   4561 H HB3  . LEU A 1 325 ? -36.642 53.578 3.223   1.00 22.90 ? 291 LEU A HB3  1 
ATOM   4562 H HG   . LEU A 1 325 ? -37.783 51.982 5.245   1.00 19.17 ? 291 LEU A HG   1 
ATOM   4563 H HD11 . LEU A 1 325 ? -39.417 53.642 5.388   1.00 21.69 ? 291 LEU A HD11 1 
ATOM   4564 H HD12 . LEU A 1 325 ? -37.986 54.239 5.733   1.00 21.69 ? 291 LEU A HD12 1 
ATOM   4565 H HD13 . LEU A 1 325 ? -38.633 54.500 4.306   1.00 21.69 ? 291 LEU A HD13 1 
ATOM   4566 H HD21 . LEU A 1 325 ? -39.691 51.984 3.753   1.00 21.34 ? 291 LEU A HD21 1 
ATOM   4567 H HD22 . LEU A 1 325 ? -38.657 52.387 2.617   1.00 21.34 ? 291 LEU A HD22 1 
ATOM   4568 H HD23 . LEU A 1 325 ? -38.501 51.001 3.377   1.00 21.34 ? 291 LEU A HD23 1 
ATOM   4569 N N    . ALA A 1 326 ? -33.366 52.342 3.184   1.00 15.41 ? 292 ALA A N    1 
ATOM   4570 C CA   . ALA A 1 326 ? -32.179 52.839 2.495   1.00 16.04 ? 292 ALA A CA   1 
ATOM   4571 C C    . ALA A 1 326 ? -31.861 51.998 1.266   1.00 15.83 ? 292 ALA A C    1 
ATOM   4572 O O    . ALA A 1 326 ? -31.547 52.541 0.201   1.00 19.29 ? 292 ALA A O    1 
ATOM   4573 C CB   . ALA A 1 326 ? -30.988 52.861 3.453   1.00 16.12 ? 292 ALA A CB   1 
ATOM   4574 H H    . ALA A 1 326 ? -33.238 52.120 4.005   1.00 18.51 ? 292 ALA A H    1 
ATOM   4575 H HA   . ALA A 1 326 ? -32.347 53.748 2.202   1.00 19.28 ? 292 ALA A HA   1 
ATOM   4576 H HB1  . ALA A 1 326 ? -30.216 53.220 2.988   1.00 19.37 ? 292 ALA A HB1  1 
ATOM   4577 H HB2  . ALA A 1 326 ? -31.206 53.421 4.215   1.00 19.37 ? 292 ALA A HB2  1 
ATOM   4578 H HB3  . ALA A 1 326 ? -30.804 51.956 3.749   1.00 19.37 ? 292 ALA A HB3  1 
ATOM   4579 N N    . GLY A 1 327 ? -31.946 50.674 1.389   1.00 14.98 ? 293 GLY A N    1 
ATOM   4580 C CA   . GLY A 1 327 ? -31.580 49.788 0.301   1.00 14.87 ? 293 GLY A CA   1 
ATOM   4581 C C    . GLY A 1 327 ? -32.743 49.018 -0.290  1.00 16.63 ? 293 GLY A C    1 
ATOM   4582 O O    . GLY A 1 327 ? -32.552 48.201 -1.195  1.00 15.30 ? 293 GLY A O    1 
ATOM   4583 H H    . GLY A 1 327 ? -32.214 50.267 2.098   1.00 18.00 ? 293 GLY A H    1 
ATOM   4584 H HA2  . GLY A 1 327 ? -31.178 50.312 -0.409  1.00 17.87 ? 293 GLY A HA2  1 
ATOM   4585 H HA3  . GLY A 1 327 ? -30.931 49.144 0.625   1.00 17.87 ? 293 GLY A HA3  1 
ATOM   4586 N N    . ALA A 1 328 ? -33.950 49.259 0.218   1.00 16.53 ? 294 ALA A N    1 
ATOM   4587 C CA   . ALA A 1 328 ? -35.113 48.524 -0.259  1.00 14.43 ? 294 ALA A CA   1 
ATOM   4588 C C    . ALA A 1 328 ? -35.260 48.676 -1.767  1.00 14.98 ? 294 ALA A C    1 
ATOM   4589 O O    . ALA A 1 328 ? -34.998 49.740 -2.333  1.00 14.46 ? 294 ALA A O    1 
ATOM   4590 C CB   . ALA A 1 328 ? -36.380 49.014 0.443   1.00 13.40 ? 294 ALA A CB   1 
ATOM   4591 H H    . ALA A 1 328 ? -34.119 49.836 0.833   1.00 19.86 ? 294 ALA A H    1 
ATOM   4592 H HA   . ALA A 1 328 ? -34.999 47.582 -0.054  1.00 17.34 ? 294 ALA A HA   1 
ATOM   4593 H HB1  . ALA A 1 328 ? -37.140 48.513 0.107   1.00 16.11 ? 294 ALA A HB1  1 
ATOM   4594 H HB2  . ALA A 1 328 ? -36.287 48.873 1.398   1.00 16.11 ? 294 ALA A HB2  1 
ATOM   4595 H HB3  . ALA A 1 328 ? -36.499 49.958 0.257   1.00 16.11 ? 294 ALA A HB3  1 
ATOM   4596 N N    . GLN A 1 329 ? -35.666 47.595 -2.415  1.00 15.53 ? 295 GLN A N    1 
ATOM   4597 C CA   . GLN A 1 329 ? -35.972 47.573 -3.836  1.00 18.84 ? 295 GLN A CA   1 
ATOM   4598 C C    . GLN A 1 329 ? -37.393 47.057 -4.013  1.00 21.62 ? 295 GLN A C    1 
ATOM   4599 O O    . GLN A 1 329 ? -38.060 46.674 -3.050  1.00 14.75 ? 295 GLN A O    1 
ATOM   4600 C CB   . GLN A 1 329 ? -34.968 46.701 -4.597  1.00 16.08 ? 295 GLN A CB   1 
ATOM   4601 C CG   . GLN A 1 329 ? -33.511 47.018 -4.292  1.00 17.33 ? 295 GLN A CG   1 
ATOM   4602 C CD   . GLN A 1 329 ? -33.098 48.393 -4.779  1.00 16.06 ? 295 GLN A CD   1 
ATOM   4603 O OE1  . GLN A 1 329 ? -33.377 48.772 -5.917  1.00 24.51 ? 295 GLN A OE1  1 
ATOM   4604 N NE2  . GLN A 1 329 ? -32.429 49.148 -3.918  1.00 17.52 ? 295 GLN A NE2  1 
ATOM   4605 H H    . GLN A 1 329 ? -35.776 46.831 -2.037  1.00 18.67 ? 295 GLN A H    1 
ATOM   4606 H HA   . GLN A 1 329 ? -35.914 48.471 -4.199  1.00 22.64 ? 295 GLN A HA   1 
ATOM   4607 H HB2  . GLN A 1 329 ? -35.123 45.773 -4.361  1.00 19.32 ? 295 GLN A HB2  1 
ATOM   4608 H HB3  . GLN A 1 329 ? -35.105 46.829 -5.548  1.00 19.32 ? 295 GLN A HB3  1 
ATOM   4609 H HG2  . GLN A 1 329 ? -33.374 46.986 -3.333  1.00 20.82 ? 295 GLN A HG2  1 
ATOM   4610 H HG3  . GLN A 1 329 ? -32.946 46.362 -4.730  1.00 20.82 ? 295 GLN A HG3  1 
ATOM   4611 H HE21 . GLN A 1 329 ? -32.252 48.850 -3.131  1.00 21.06 ? 295 GLN A HE21 1 
ATOM   4612 H HE22 . GLN A 1 329 ? -32.173 49.937 -4.146  1.00 21.06 ? 295 GLN A HE22 1 
ATOM   4613 N N    . GLU A 1 330 ? -37.866 47.051 -5.255  1.00 19.23 ? 296 GLU A N    1 
ATOM   4614 C CA   . GLU A 1 330 ? -39.154 46.433 -5.527  1.00 17.80 ? 296 GLU A CA   1 
ATOM   4615 C C    . GLU A 1 330 ? -39.127 44.984 -5.058  1.00 16.85 ? 296 GLU A C    1 
ATOM   4616 O O    . GLU A 1 330 ? -38.141 44.269 -5.256  1.00 18.27 ? 296 GLU A O    1 
ATOM   4617 C CB   . GLU A 1 330 ? -39.487 46.508 -7.017  1.00 25.53 ? 296 GLU A CB   1 
ATOM   4618 C CG   . GLU A 1 330 ? -40.812 45.849 -7.377  1.00 32.33 ? 296 GLU A CG   1 
ATOM   4619 C CD   . GLU A 1 330 ? -41.703 46.734 -8.230  1.00 40.42 ? 296 GLU A CD   1 
ATOM   4620 O OE1  . GLU A 1 330 ? -41.635 47.973 -8.080  1.00 41.03 ? 296 GLU A OE1  1 
ATOM   4621 O OE2  . GLU A 1 330 ? -42.476 46.187 -9.047  1.00 34.63 ? 296 GLU A OE2  1 
ATOM   4622 H H    . GLU A 1 330 ? -37.470 47.389 -5.939  1.00 23.10 ? 296 GLU A H    1 
ATOM   4623 H HA   . GLU A 1 330 ? -39.855 46.907 -5.053  1.00 21.39 ? 296 GLU A HA   1 
ATOM   4624 H HB2  . GLU A 1 330 ? -39.537 47.440 -7.280  1.00 30.66 ? 296 GLU A HB2  1 
ATOM   4625 H HB3  . GLU A 1 330 ? -38.786 46.059 -7.516  1.00 30.66 ? 296 GLU A HB3  1 
ATOM   4626 H HG2  . GLU A 1 330 ? -40.635 45.035 -7.874  1.00 38.82 ? 296 GLU A HG2  1 
ATOM   4627 H HG3  . GLU A 1 330 ? -41.293 45.640 -6.560  1.00 38.82 ? 296 GLU A HG3  1 
ATOM   4628 N N    . ASN A 1 331 ? -40.213 44.562 -4.412  1.00 14.64 ? 297 ASN A N    1 
ATOM   4629 C CA   . ASN A 1 331 ? -40.361 43.224 -3.845  1.00 17.08 ? 297 ASN A CA   1 
ATOM   4630 C C    . ASN A 1 331 ? -39.499 43.007 -2.603  1.00 15.20 ? 297 ASN A C    1 
ATOM   4631 O O    . ASN A 1 331 ? -39.275 41.860 -2.201  1.00 17.41 ? 297 ASN A O    1 
ATOM   4632 C CB   . ASN A 1 331 ? -40.057 42.144 -4.889  1.00 15.34 ? 297 ASN A CB   1 
ATOM   4633 C CG   . ASN A 1 331 ? -40.860 42.324 -6.164  1.00 18.71 ? 297 ASN A CG   1 
ATOM   4634 O OD1  . ASN A 1 331 ? -42.090 42.365 -6.134  1.00 19.56 ? 297 ASN A OD1  1 
ATOM   4635 N ND2  . ASN A 1 331 ? -40.168 42.434 -7.292  1.00 17.84 ? 297 ASN A ND2  1 
ATOM   4636 H H    . ASN A 1 331 ? -40.906 45.055 -4.284  1.00 17.59 ? 297 ASN A H    1 
ATOM   4637 H HA   . ASN A 1 331 ? -41.285 43.122 -3.566  1.00 20.52 ? 297 ASN A HA   1 
ATOM   4638 H HB2  . ASN A 1 331 ? -39.115 42.181 -5.119  1.00 18.43 ? 297 ASN A HB2  1 
ATOM   4639 H HB3  . ASN A 1 331 ? -40.273 41.274 -4.517  1.00 18.43 ? 297 ASN A HB3  1 
ATOM   4640 H HD21 . ASN A 1 331 ? -40.579 42.538 -8.040  1.00 21.44 ? 297 ASN A HD21 1 
ATOM   4641 H HD22 . ASN A 1 331 ? -39.309 42.401 -7.274  1.00 21.44 ? 297 ASN A HD22 1 
ATOM   4642 N N    . SER A 1 332 ? -39.013 44.079 -1.979  1.00 15.57 ? 298 SER A N    1 
ATOM   4643 C CA   . SER A 1 332 ? -38.338 43.989 -0.689  1.00 13.74 ? 298 SER A CA   1 
ATOM   4644 C C    . SER A 1 332 ? -39.359 44.156 0.430   1.00 14.65 ? 298 SER A C    1 
ATOM   4645 O O    . SER A 1 332 ? -40.261 44.995 0.341   1.00 17.57 ? 298 SER A O    1 
ATOM   4646 C CB   . SER A 1 332 ? -37.250 45.057 -0.561  1.00 15.36 ? 298 SER A CB   1 
ATOM   4647 O OG   . SER A 1 332 ? -36.118 44.744 -1.354  1.00 15.60 ? 298 SER A OG   1 
ATOM   4648 H H    . SER A 1 332 ? -39.062 44.880 -2.288  1.00 18.71 ? 298 SER A H    1 
ATOM   4649 H HA   . SER A 1 332 ? -37.912 43.122 -0.604  1.00 16.51 ? 298 SER A HA   1 
ATOM   4650 H HB2  . SER A 1 332 ? -37.612 45.908 -0.854  1.00 18.46 ? 298 SER A HB2  1 
ATOM   4651 H HB3  . SER A 1 332 ? -36.975 45.115 0.367   1.00 18.46 ? 298 SER A HB3  1 
ATOM   4652 H HG   . SER A 1 332 ? -36.307 44.826 -2.169  1.00 18.75 ? 298 SER A HG   1 
ATOM   4653 N N    . TYR A 1 333 ? -39.210 43.361 1.490   1.00 15.45 ? 299 TYR A N    1 
ATOM   4654 C CA   . TYR A 1 333 ? -40.210 43.300 2.547   1.00 16.58 ? 299 TYR A CA   1 
ATOM   4655 C C    . TYR A 1 333 ? -39.566 43.424 3.919   1.00 16.48 ? 299 TYR A C    1 
ATOM   4656 O O    . TYR A 1 333 ? -38.508 42.846 4.183   1.00 16.83 ? 299 TYR A O    1 
ATOM   4657 C CB   . TYR A 1 333 ? -41.013 42.001 2.468   1.00 17.03 ? 299 TYR A CB   1 
ATOM   4658 C CG   . TYR A 1 333 ? -41.922 41.953 1.267   1.00 17.03 ? 299 TYR A CG   1 
ATOM   4659 C CD1  . TYR A 1 333 ? -43.156 42.590 1.278   1.00 17.67 ? 299 TYR A CD1  1 
ATOM   4660 C CD2  . TYR A 1 333 ? -41.541 41.283 0.116   1.00 15.00 ? 299 TYR A CD2  1 
ATOM   4661 C CE1  . TYR A 1 333 ? -43.987 42.551 0.176   1.00 16.93 ? 299 TYR A CE1  1 
ATOM   4662 C CE2  . TYR A 1 333 ? -42.361 41.240 -0.988  1.00 17.22 ? 299 TYR A CE2  1 
ATOM   4663 C CZ   . TYR A 1 333 ? -43.581 41.874 -0.956  1.00 18.10 ? 299 TYR A CZ   1 
ATOM   4664 O OH   . TYR A 1 333 ? -44.394 41.824 -2.063  1.00 19.30 ? 299 TYR A OH   1 
ATOM   4665 H H    . TYR A 1 333 ? -38.534 42.846 1.616   1.00 18.56 ? 299 TYR A H    1 
ATOM   4666 H HA   . TYR A 1 333 ? -40.813 44.053 2.447   1.00 19.92 ? 299 TYR A HA   1 
ATOM   4667 H HB2  . TYR A 1 333 ? -40.399 41.253 2.410   1.00 20.46 ? 299 TYR A HB2  1 
ATOM   4668 H HB3  . TYR A 1 333 ? -41.561 41.920 3.264   1.00 20.46 ? 299 TYR A HB3  1 
ATOM   4669 H HD1  . TYR A 1 333 ? -43.426 43.051 2.040   1.00 21.24 ? 299 TYR A HD1  1 
ATOM   4670 H HD2  . TYR A 1 333 ? -40.716 40.855 0.089   1.00 18.03 ? 299 TYR A HD2  1 
ATOM   4671 H HE1  . TYR A 1 333 ? -44.813 42.977 0.197   1.00 20.35 ? 299 TYR A HE1  1 
ATOM   4672 H HE2  . TYR A 1 333 ? -42.091 40.784 -1.753  1.00 20.69 ? 299 TYR A HE2  1 
ATOM   4673 H HH   . TYR A 1 333 ? -43.989 41.458 -2.701  1.00 23.19 ? 299 TYR A HH   1 
ATOM   4674 N N    . PHE A 1 334 ? -40.243 44.166 4.789   1.00 14.26 ? 300 PHE A N    1 
ATOM   4675 C CA   . PHE A 1 334 ? -39.775 44.497 6.127   1.00 15.21 ? 300 PHE A CA   1 
ATOM   4676 C C    . PHE A 1 334 ? -40.540 43.661 7.144   1.00 18.82 ? 300 PHE A C    1 
ATOM   4677 O O    . PHE A 1 334 ? -41.775 43.616 7.113   1.00 16.05 ? 300 PHE A O    1 
ATOM   4678 C CB   . PHE A 1 334 ? -39.978 45.993 6.384   1.00 12.60 ? 300 PHE A CB   1 
ATOM   4679 C CG   . PHE A 1 334 ? -39.436 46.482 7.693   1.00 16.67 ? 300 PHE A CG   1 
ATOM   4680 C CD1  . PHE A 1 334 ? -38.072 46.500 7.938   1.00 14.23 ? 300 PHE A CD1  1 
ATOM   4681 C CD2  . PHE A 1 334 ? -40.293 46.972 8.663   1.00 16.51 ? 300 PHE A CD2  1 
ATOM   4682 C CE1  . PHE A 1 334 ? -37.578 46.972 9.142   1.00 16.03 ? 300 PHE A CE1  1 
ATOM   4683 C CE2  . PHE A 1 334 ? -39.805 47.448 9.864   1.00 20.37 ? 300 PHE A CE2  1 
ATOM   4684 C CZ   . PHE A 1 334 ? -38.447 47.447 10.105  1.00 19.75 ? 300 PHE A CZ   1 
ATOM   4685 H H    . PHE A 1 334 ? -41.015 44.504 4.617   1.00 17.14 ? 300 PHE A H    1 
ATOM   4686 H HA   . PHE A 1 334 ? -38.833 44.288 6.225   1.00 18.28 ? 300 PHE A HA   1 
ATOM   4687 H HB2  . PHE A 1 334 ? -39.534 46.490 5.679   1.00 15.14 ? 300 PHE A HB2  1 
ATOM   4688 H HB3  . PHE A 1 334 ? -40.930 46.181 6.373   1.00 15.14 ? 300 PHE A HB3  1 
ATOM   4689 H HD1  . PHE A 1 334 ? -37.483 46.191 7.288   1.00 17.10 ? 300 PHE A HD1  1 
ATOM   4690 H HD2  . PHE A 1 334 ? -41.209 46.980 8.505   1.00 19.84 ? 300 PHE A HD2  1 
ATOM   4691 H HE1  . PHE A 1 334 ? -36.662 46.969 9.302   1.00 19.26 ? 300 PHE A HE1  1 
ATOM   4692 H HE2  . PHE A 1 334 ? -40.392 47.770 10.509  1.00 24.47 ? 300 PHE A HE2  1 
ATOM   4693 H HZ   . PHE A 1 334 ? -38.117 47.766 10.914  1.00 23.73 ? 300 PHE A HZ   1 
ATOM   4694 N N    . ILE A 1 335 ? -39.807 42.985 8.025   1.00 16.71 ? 301 ILE A N    1 
ATOM   4695 C CA   . ILE A 1 335 ? -40.389 42.243 9.138   1.00 18.96 ? 301 ILE A CA   1 
ATOM   4696 C C    . ILE A 1 335 ? -39.709 42.721 10.411  1.00 15.83 ? 301 ILE A C    1 
ATOM   4697 O O    . ILE A 1 335 ? -38.481 42.639 10.530  1.00 22.19 ? 301 ILE A O    1 
ATOM   4698 C CB   . ILE A 1 335 ? -40.231 40.722 8.976   1.00 17.02 ? 301 ILE A CB   1 
ATOM   4699 C CG1  . ILE A 1 335 ? -40.791 40.278 7.622   1.00 17.45 ? 301 ILE A CG1  1 
ATOM   4700 C CG2  . ILE A 1 335 ? -40.921 39.996 10.135  1.00 15.22 ? 301 ILE A CG2  1 
ATOM   4701 C CD1  . ILE A 1 335 ? -40.891 38.775 7.449   1.00 16.60 ? 301 ILE A CD1  1 
ATOM   4702 H H    . ILE A 1 335 ? -38.949 42.940 7.997   1.00 20.08 ? 301 ILE A H    1 
ATOM   4703 H HA   . ILE A 1 335 ? -41.337 42.440 9.196   1.00 22.77 ? 301 ILE A HA   1 
ATOM   4704 H HB   . ILE A 1 335 ? -39.289 40.494 8.999   1.00 20.45 ? 301 ILE A HB   1 
ATOM   4705 H HG12 . ILE A 1 335 ? -41.684 40.644 7.520   1.00 20.97 ? 301 ILE A HG12 1 
ATOM   4706 H HG13 . ILE A 1 335 ? -40.212 40.616 6.921   1.00 20.97 ? 301 ILE A HG13 1 
ATOM   4707 H HG21 . ILE A 1 335 ? -40.816 39.039 10.016  1.00 18.29 ? 301 ILE A HG21 1 
ATOM   4708 H HG22 . ILE A 1 335 ? -40.510 40.272 10.970  1.00 18.29 ? 301 ILE A HG22 1 
ATOM   4709 H HG23 . ILE A 1 335 ? -41.863 40.228 10.137  1.00 18.29 ? 301 ILE A HG23 1 
ATOM   4710 H HD11 . ILE A 1 335 ? -41.048 38.574 6.514   1.00 19.94 ? 301 ILE A HD11 1 
ATOM   4711 H HD12 . ILE A 1 335 ? -40.059 38.369 7.739   1.00 19.94 ? 301 ILE A HD12 1 
ATOM   4712 H HD13 . ILE A 1 335 ? -41.626 38.444 7.988   1.00 19.94 ? 301 ILE A HD13 1 
ATOM   4713 N N    . TYR A 1 336 ? -40.502 43.214 11.360  1.00 19.41 ? 302 TYR A N    1 
ATOM   4714 C CA   . TYR A 1 336 ? -39.993 43.801 12.595  1.00 18.99 ? 302 TYR A CA   1 
ATOM   4715 C C    . TYR A 1 336 ? -40.730 43.167 13.766  1.00 17.32 ? 302 TYR A C    1 
ATOM   4716 O O    . TYR A 1 336 ? -41.934 43.384 13.940  1.00 16.28 ? 302 TYR A O    1 
ATOM   4717 C CB   . TYR A 1 336 ? -40.171 45.320 12.582  1.00 15.60 ? 302 TYR A CB   1 
ATOM   4718 C CG   . TYR A 1 336 ? -39.634 46.041 13.799  1.00 16.33 ? 302 TYR A CG   1 
ATOM   4719 C CD1  . TYR A 1 336 ? -38.273 46.067 14.072  1.00 17.29 ? 302 TYR A CD1  1 
ATOM   4720 C CD2  . TYR A 1 336 ? -40.487 46.715 14.661  1.00 19.51 ? 302 TYR A CD2  1 
ATOM   4721 C CE1  . TYR A 1 336 ? -37.779 46.731 15.175  1.00 17.76 ? 302 TYR A CE1  1 
ATOM   4722 C CE2  . TYR A 1 336 ? -40.002 47.384 15.767  1.00 22.66 ? 302 TYR A CE2  1 
ATOM   4723 C CZ   . TYR A 1 336 ? -38.647 47.389 16.020  1.00 20.71 ? 302 TYR A CZ   1 
ATOM   4724 O OH   . TYR A 1 336 ? -38.159 48.052 17.122  1.00 23.02 ? 302 TYR A OH   1 
ATOM   4725 H H    . TYR A 1 336 ? -41.361 43.218 11.309  1.00 23.31 ? 302 TYR A H    1 
ATOM   4726 H HA   . TYR A 1 336 ? -39.048 43.603 12.692  1.00 22.82 ? 302 TYR A HA   1 
ATOM   4727 H HB2  . TYR A 1 336 ? -39.710 45.676 11.807  1.00 18.75 ? 302 TYR A HB2  1 
ATOM   4728 H HB3  . TYR A 1 336 ? -41.120 45.517 12.524  1.00 18.75 ? 302 TYR A HB3  1 
ATOM   4729 H HD1  . TYR A 1 336 ? -37.684 45.629 13.500  1.00 20.78 ? 302 TYR A HD1  1 
ATOM   4730 H HD2  . TYR A 1 336 ? -41.402 46.717 14.491  1.00 23.44 ? 302 TYR A HD2  1 
ATOM   4731 H HE1  . TYR A 1 336 ? -36.865 46.734 15.349  1.00 21.34 ? 302 TYR A HE1  1 
ATOM   4732 H HE2  . TYR A 1 336 ? -40.586 47.828 16.338  1.00 27.22 ? 302 TYR A HE2  1 
ATOM   4733 H HH   . TYR A 1 336 ? -38.776 48.486 17.492  1.00 27.65 ? 302 TYR A HH   1 
ATOM   4734 N N    . ASN A 1 337 ? -40.011 42.382 14.554  1.00 18.16 ? 303 ASN A N    1 
ATOM   4735 C CA   . ASN A 1 337 ? -40.551 41.696 15.725  1.00 20.14 ? 303 ASN A CA   1 
ATOM   4736 C C    . ASN A 1 337 ? -39.365 41.079 16.458  1.00 19.99 ? 303 ASN A C    1 
ATOM   4737 O O    . ASN A 1 337 ? -38.208 41.285 16.070  1.00 16.15 ? 303 ASN A O    1 
ATOM   4738 C CB   . ASN A 1 337 ? -41.600 40.657 15.323  1.00 20.18 ? 303 ASN A CB   1 
ATOM   4739 C CG   . ASN A 1 337 ? -41.043 39.601 14.390  1.00 18.51 ? 303 ASN A CG   1 
ATOM   4740 O OD1  . ASN A 1 337 ? -39.972 39.042 14.634  1.00 21.14 ? 303 ASN A OD1  1 
ATOM   4741 N ND2  . ASN A 1 337 ? -41.767 39.323 13.313  1.00 18.75 ? 303 ASN A ND2  1 
ATOM   4742 H H    . ASN A 1 337 ? -39.175 42.223 14.429  1.00 21.82 ? 303 ASN A H    1 
ATOM   4743 H HA   . ASN A 1 337 ? -40.980 42.339 16.312  1.00 24.20 ? 303 ASN A HA   1 
ATOM   4744 H HB2  . ASN A 1 337 ? -41.927 40.212 16.120  1.00 24.24 ? 303 ASN A HB2  1 
ATOM   4745 H HB3  . ASN A 1 337 ? -42.331 41.104 14.869  1.00 24.24 ? 303 ASN A HB3  1 
ATOM   4746 H HD21 . ASN A 1 337 ? -41.493 38.730 12.752  1.00 22.53 ? 303 ASN A HD21 1 
ATOM   4747 H HD22 . ASN A 1 337 ? -42.509 39.734 13.175  1.00 22.53 ? 303 ASN A HD22 1 
ATOM   4748 N N    . TRP A 1 338 ? -39.642 40.306 17.511  1.00 19.33 ? 304 TRP A N    1 
ATOM   4749 C CA   . TRP A 1 338 ? -38.580 39.712 18.316  1.00 20.49 ? 304 TRP A CA   1 
ATOM   4750 C C    . TRP A 1 338 ? -38.634 38.188 18.326  1.00 20.64 ? 304 TRP A C    1 
ATOM   4751 O O    . TRP A 1 338 ? -38.111 37.562 19.254  1.00 20.85 ? 304 TRP A O    1 
ATOM   4752 C CB   . TRP A 1 338 ? -38.616 40.255 19.749  1.00 23.63 ? 304 TRP A CB   1 
ATOM   4753 C CG   . TRP A 1 338 ? -39.942 40.168 20.455  1.00 21.00 ? 304 TRP A CG   1 
ATOM   4754 C CD1  . TRP A 1 338 ? -40.409 39.119 21.193  1.00 21.56 ? 304 TRP A CD1  1 
ATOM   4755 C CD2  . TRP A 1 338 ? -40.950 41.187 20.527  1.00 23.39 ? 304 TRP A CD2  1 
ATOM   4756 N NE1  . TRP A 1 338 ? -41.648 39.415 21.707  1.00 18.93 ? 304 TRP A NE1  1 
ATOM   4757 C CE2  . TRP A 1 338 ? -42.003 40.678 21.312  1.00 20.88 ? 304 TRP A CE2  1 
ATOM   4758 C CE3  . TRP A 1 338 ? -41.066 42.475 19.997  1.00 22.14 ? 304 TRP A CE3  1 
ATOM   4759 C CZ2  . TRP A 1 338 ? -43.158 41.411 21.578  1.00 24.65 ? 304 TRP A CZ2  1 
ATOM   4760 C CZ3  . TRP A 1 338 ? -42.215 43.201 20.261  1.00 24.50 ? 304 TRP A CZ3  1 
ATOM   4761 C CH2  . TRP A 1 338 ? -43.245 42.667 21.044  1.00 26.13 ? 304 TRP A CH2  1 
ATOM   4762 H H    . TRP A 1 338 ? -40.437 40.113 17.776  1.00 23.22 ? 304 TRP A H    1 
ATOM   4763 H HA   . TRP A 1 338 ? -37.732 39.967 17.921  1.00 24.62 ? 304 TRP A HA   1 
ATOM   4764 H HB2  . TRP A 1 338 ? -37.977 39.754 20.279  1.00 28.38 ? 304 TRP A HB2  1 
ATOM   4765 H HB3  . TRP A 1 338 ? -38.366 41.192 19.725  1.00 28.38 ? 304 TRP A HB3  1 
ATOM   4766 H HD1  . TRP A 1 338 ? -39.954 38.320 21.329  1.00 25.90 ? 304 TRP A HD1  1 
ATOM   4767 H HE1  . TRP A 1 338 ? -42.124 38.892 22.197  1.00 22.75 ? 304 TRP A HE1  1 
ATOM   4768 H HE3  . TRP A 1 338 ? -40.385 42.838 19.478  1.00 26.59 ? 304 TRP A HE3  1 
ATOM   4769 H HZ2  . TRP A 1 338 ? -43.844 41.059 22.099  1.00 29.61 ? 304 TRP A HZ2  1 
ATOM   4770 H HZ3  . TRP A 1 338 ? -42.304 44.059 19.912  1.00 29.43 ? 304 TRP A HZ3  1 
ATOM   4771 H HH2  . TRP A 1 338 ? -44.006 43.178 21.205  1.00 31.39 ? 304 TRP A HH2  1 
ATOM   4772 N N    . GLY A 1 339 ? -39.229 37.572 17.312  1.00 20.72 ? 305 GLY A N    1 
ATOM   4773 C CA   . GLY A 1 339 ? -39.228 36.125 17.242  1.00 21.15 ? 305 GLY A CA   1 
ATOM   4774 C C    . GLY A 1 339 ? -40.100 35.615 16.116  1.00 18.84 ? 305 GLY A C    1 
ATOM   4775 O O    . GLY A 1 339 ? -40.699 36.383 15.353  1.00 15.83 ? 305 GLY A O    1 
ATOM   4776 H H    . GLY A 1 339 ? -39.632 37.966 16.664  1.00 24.89 ? 305 GLY A H    1 
ATOM   4777 H HA2  . GLY A 1 339 ? -38.323 35.808 17.097  1.00 25.41 ? 305 GLY A HA2  1 
ATOM   4778 H HA3  . GLY A 1 339 ? -39.560 35.760 18.077  1.00 25.41 ? 305 GLY A HA3  1 
ATOM   4779 N N    . TYR A 1 340 ? -40.163 34.285 16.037  1.00 19.61 ? 306 TYR A N    1 
ATOM   4780 C CA   . TYR A 1 340 ? -40.884 33.588 14.981  1.00 22.65 ? 306 TYR A CA   1 
ATOM   4781 C C    . TYR A 1 340 ? -42.162 32.925 15.467  1.00 23.01 ? 306 TYR A C    1 
ATOM   4782 O O    . TYR A 1 340 ? -42.841 32.268 14.674  1.00 21.59 ? 306 TYR A O    1 
ATOM   4783 C CB   . TYR A 1 340 ? -39.969 32.549 14.327  1.00 21.92 ? 306 TYR A CB   1 
ATOM   4784 C CG   . TYR A 1 340 ? -38.735 33.181 13.743  1.00 23.71 ? 306 TYR A CG   1 
ATOM   4785 C CD1  . TYR A 1 340 ? -38.798 33.898 12.556  1.00 25.21 ? 306 TYR A CD1  1 
ATOM   4786 C CD2  . TYR A 1 340 ? -37.514 33.095 14.393  1.00 24.17 ? 306 TYR A CD2  1 
ATOM   4787 C CE1  . TYR A 1 340 ? -37.677 34.492 12.024  1.00 18.68 ? 306 TYR A CE1  1 
ATOM   4788 C CE2  . TYR A 1 340 ? -36.387 33.686 13.869  1.00 23.13 ? 306 TYR A CE2  1 
ATOM   4789 C CZ   . TYR A 1 340 ? -36.475 34.383 12.686  1.00 23.70 ? 306 TYR A CZ   1 
ATOM   4790 O OH   . TYR A 1 340 ? -35.355 34.975 12.163  1.00 26.36 ? 306 TYR A OH   1 
ATOM   4791 H H    . TYR A 1 340 ? -39.786 33.754 16.598  1.00 23.56 ? 306 TYR A H    1 
ATOM   4792 H HA   . TYR A 1 340 ? -41.138 34.231 14.300  1.00 27.20 ? 306 TYR A HA   1 
ATOM   4793 H HB2  . TYR A 1 340 ? -39.693 31.902 14.995  1.00 26.33 ? 306 TYR A HB2  1 
ATOM   4794 H HB3  . TYR A 1 340 ? -40.451 32.104 13.613  1.00 26.33 ? 306 TYR A HB3  1 
ATOM   4795 H HD1  . TYR A 1 340 ? -39.612 33.978 12.113  1.00 30.28 ? 306 TYR A HD1  1 
ATOM   4796 H HD2  . TYR A 1 340 ? -37.455 32.631 15.197  1.00 29.04 ? 306 TYR A HD2  1 
ATOM   4797 H HE1  . TYR A 1 340 ? -37.731 34.963 11.224  1.00 22.44 ? 306 TYR A HE1  1 
ATOM   4798 H HE2  . TYR A 1 340 ? -35.572 33.614 14.311  1.00 27.78 ? 306 TYR A HE2  1 
ATOM   4799 H HH   . TYR A 1 340 ? -34.712 34.893 12.696  1.00 31.66 ? 306 TYR A HH   1 
ATOM   4800 N N    . ARG A 1 341 ? -42.502 33.061 16.742  1.00 20.95 ? 307 ARG A N    1 
ATOM   4801 C CA   . ARG A 1 341 ? -43.855 32.765 17.176  1.00 22.27 ? 307 ARG A CA   1 
ATOM   4802 C C    . ARG A 1 341 ? -44.748 33.953 16.848  1.00 19.24 ? 307 ARG A C    1 
ATOM   4803 O O    . ARG A 1 341 ? -44.308 35.106 16.859  1.00 18.44 ? 307 ARG A O    1 
ATOM   4804 C CB   . ARG A 1 341 ? -43.900 32.467 18.674  1.00 26.56 ? 307 ARG A CB   1 
ATOM   4805 C CG   . ARG A 1 341 ? -42.964 31.357 19.114  1.00 33.00 ? 307 ARG A CG   1 
ATOM   4806 H H    . ARG A 1 341 ? -41.972 33.322 17.367  1.00 25.16 ? 307 ARG A H    1 
ATOM   4807 H HA   . ARG A 1 341 ? -44.189 31.975 16.722  1.00 26.75 ? 307 ARG A HA   1 
ATOM   4808 H HB2  . ARG A 1 341 ? -43.651 33.271 19.157  1.00 31.90 ? 307 ARG A HB2  1 
ATOM   4809 H HB3  . ARG A 1 341 ? -44.802 32.203 18.911  1.00 31.90 ? 307 ARG A HB3  1 
ATOM   4810 H HG2  . ARG A 1 341 ? -43.062 30.598 18.518  1.00 39.63 ? 307 ARG A HG2  1 
ATOM   4811 H HG3  . ARG A 1 341 ? -42.049 31.679 19.094  1.00 39.63 ? 307 ARG A HG3  1 
ATOM   4812 N N    . MET A 1 342 ? -46.009 33.662 16.525  1.00 20.76 ? 308 MET A N    1 
ATOM   4813 C CA   . MET A 1 342 ? -46.960 34.736 16.258  1.00 20.24 ? 308 MET A CA   1 
ATOM   4814 C C    . MET A 1 342 ? -46.944 35.777 17.367  1.00 23.83 ? 308 MET A C    1 
ATOM   4815 O O    . MET A 1 342 ? -47.020 36.983 17.102  1.00 22.50 ? 308 MET A O    1 
ATOM   4816 C CB   . MET A 1 342 ? -48.370 34.169 16.103  1.00 18.11 ? 308 MET A CB   1 
ATOM   4817 C CG   . MET A 1 342 ? -49.236 34.950 15.125  1.00 24.50 ? 308 MET A CG   1 
ATOM   4818 S SD   . MET A 1 342 ? -50.961 34.421 15.048  1.00 25.59 ? 308 MET A SD   1 
ATOM   4819 C CE   . MET A 1 342 ? -51.423 34.415 16.776  1.00 22.72 ? 308 MET A CE   1 
ATOM   4820 H H    . MET A 1 342 ? -46.331 32.867 16.455  1.00 24.94 ? 308 MET A H    1 
ATOM   4821 H HA   . MET A 1 342 ? -46.711 35.157 15.421  1.00 24.31 ? 308 MET A HA   1 
ATOM   4822 H HB2  . MET A 1 342 ? -48.306 33.257 15.780  1.00 21.75 ? 308 MET A HB2  1 
ATOM   4823 H HB3  . MET A 1 342 ? -48.810 34.184 16.968  1.00 21.75 ? 308 MET A HB3  1 
ATOM   4824 H HG2  . MET A 1 342 ? -49.230 35.884 15.387  1.00 29.43 ? 308 MET A HG2  1 
ATOM   4825 H HG3  . MET A 1 342 ? -48.862 34.853 14.236  1.00 29.43 ? 308 MET A HG3  1 
ATOM   4826 H HE1  . MET A 1 342 ? -52.354 34.154 16.852  1.00 27.29 ? 308 MET A HE1  1 
ATOM   4827 H HE2  . MET A 1 342 ? -50.862 33.783 17.251  1.00 27.29 ? 308 MET A HE2  1 
ATOM   4828 H HE3  . MET A 1 342 ? -51.299 35.306 17.139  1.00 27.29 ? 308 MET A HE3  1 
ATOM   4829 N N    . ASP A 1 343 ? -46.847 35.328 18.616  1.00 20.03 ? 309 ASP A N    1 
ATOM   4830 C CA   . ASP A 1 343 ? -46.925 36.215 19.768  1.00 27.40 ? 309 ASP A CA   1 
ATOM   4831 C C    . ASP A 1 343 ? -45.602 36.896 20.094  1.00 25.97 ? 309 ASP A C    1 
ATOM   4832 O O    . ASP A 1 343 ? -45.553 37.675 21.052  1.00 25.06 ? 309 ASP A O    1 
ATOM   4833 C CB   . ASP A 1 343 ? -47.413 35.433 20.990  1.00 31.46 ? 309 ASP A CB   1 
ATOM   4834 C CG   . ASP A 1 343 ? -46.330 34.564 21.594  1.00 31.16 ? 309 ASP A CG   1 
ATOM   4835 H H    . ASP A 1 343 ? -46.733 34.501 18.823  1.00 24.06 ? 309 ASP A H    1 
ATOM   4836 H HA   . ASP A 1 343 ? -47.571 36.912 19.574  1.00 32.90 ? 309 ASP A HA   1 
ATOM   4837 H HB2  . ASP A 1 343 ? -47.710 36.059 21.669  1.00 37.78 ? 309 ASP A HB2  1 
ATOM   4838 H HB3  . ASP A 1 343 ? -48.148 34.857 20.726  1.00 37.78 ? 309 ASP A HB3  1 
ATOM   4839 N N    . ASP A 1 344 ? -44.539 36.635 19.332  1.00 19.48 ? 310 ASP A N    1 
ATOM   4840 C CA   . ASP A 1 344 ? -43.263 37.306 19.552  1.00 19.31 ? 310 ASP A CA   1 
ATOM   4841 C C    . ASP A 1 344 ? -43.286 38.706 18.949  1.00 19.95 ? 310 ASP A C    1 
ATOM   4842 O O    . ASP A 1 344 ? -42.352 39.098 18.241  1.00 21.38 ? 310 ASP A O    1 
ATOM   4843 C CB   . ASP A 1 344 ? -42.114 36.496 18.944  1.00 22.18 ? 310 ASP A CB   1 
ATOM   4844 C CG   . ASP A 1 344 ? -41.754 35.276 19.770  1.00 24.88 ? 310 ASP A CG   1 
ATOM   4845 O OD1  . ASP A 1 344 ? -41.968 35.300 21.000  1.00 23.04 ? 310 ASP A OD1  1 
ATOM   4846 O OD2  . ASP A 1 344 ? -41.244 34.297 19.185  1.00 20.37 ? 310 ASP A OD2  1 
ATOM   4847 H H    . ASP A 1 344 ? -44.533 36.072 18.682  1.00 23.40 ? 310 ASP A H    1 
ATOM   4848 H HA   . ASP A 1 344 ? -43.107 37.381 20.506  1.00 23.20 ? 310 ASP A HA   1 
ATOM   4849 H HB2  . ASP A 1 344 ? -42.373 36.193 18.060  1.00 26.64 ? 310 ASP A HB2  1 
ATOM   4850 H HB3  . ASP A 1 344 ? -41.327 37.060 18.884  1.00 26.64 ? 310 ASP A HB3  1 
ATOM   4851 N N    . GLY A 1 345 ? -44.342 39.468 19.225  1.00 23.27 ? 311 GLY A N    1 
ATOM   4852 C CA   . GLY A 1 345 ? -44.519 40.752 18.578  1.00 23.96 ? 311 GLY A CA   1 
ATOM   4853 C C    . GLY A 1 345 ? -44.916 40.673 17.123  1.00 23.59 ? 311 GLY A C    1 
ATOM   4854 O O    . GLY A 1 345 ? -44.860 41.690 16.423  1.00 20.52 ? 311 GLY A O    1 
ATOM   4855 H H    . GLY A 1 345 ? -44.963 39.261 19.782  1.00 27.95 ? 311 GLY A H    1 
ATOM   4856 H HA2  . GLY A 1 345 ? -45.211 41.245 19.048  1.00 28.78 ? 311 GLY A HA2  1 
ATOM   4857 H HA3  . GLY A 1 345 ? -43.687 41.247 18.632  1.00 28.78 ? 311 GLY A HA3  1 
ATOM   4858 N N    . GLY A 1 346 ? -45.324 39.494 16.645  1.00 21.47 ? 312 GLY A N    1 
ATOM   4859 C CA   . GLY A 1 346 ? -45.628 39.336 15.234  1.00 19.38 ? 312 GLY A CA   1 
ATOM   4860 C C    . GLY A 1 346 ? -46.835 40.131 14.783  1.00 20.38 ? 312 GLY A C    1 
ATOM   4861 O O    . GLY A 1 346 ? -46.886 40.587 13.637  1.00 22.44 ? 312 GLY A O    1 
ATOM   4862 H H    . GLY A 1 346 ? -45.431 38.782 17.116  1.00 25.79 ? 312 GLY A H    1 
ATOM   4863 H HA2  . GLY A 1 346 ? -44.864 39.626 14.711  1.00 23.28 ? 312 GLY A HA2  1 
ATOM   4864 H HA3  . GLY A 1 346 ? -45.800 38.399 15.050  1.00 23.28 ? 312 GLY A HA3  1 
ATOM   4865 N N    . LEU A 1 347 ? -47.818 40.309 15.664  1.00 19.37 ? 313 LEU A N    1 
ATOM   4866 C CA   . LEU A 1 347 ? -49.044 41.021 15.334  1.00 23.78 ? 313 LEU A CA   1 
ATOM   4867 C C    . LEU A 1 347 ? -49.068 42.437 15.897  1.00 29.38 ? 313 LEU A C    1 
ATOM   4868 O O    . LEU A 1 347 ? -50.131 43.065 15.920  1.00 28.09 ? 313 LEU A O    1 
ATOM   4869 C CB   . LEU A 1 347 ? -50.258 40.235 15.835  1.00 26.14 ? 313 LEU A CB   1 
ATOM   4870 C CG   . LEU A 1 347 ? -50.341 38.777 15.374  1.00 24.40 ? 313 LEU A CG   1 
ATOM   4871 C CD1  . LEU A 1 347 ? -51.742 38.221 15.582  1.00 26.56 ? 313 LEU A CD1  1 
ATOM   4872 C CD2  . LEU A 1 347 ? -49.928 38.641 13.916  1.00 27.52 ? 313 LEU A CD2  1 
ATOM   4873 H H    . LEU A 1 347 ? -47.794 40.020 16.473  1.00 23.27 ? 313 LEU A H    1 
ATOM   4874 H HA   . LEU A 1 347 ? -49.111 41.088 14.369  1.00 28.56 ? 313 LEU A HA   1 
ATOM   4875 H HB2  . LEU A 1 347 ? -50.238 40.230 16.805  1.00 31.40 ? 313 LEU A HB2  1 
ATOM   4876 H HB3  . LEU A 1 347 ? -51.060 40.683 15.522  1.00 31.40 ? 313 LEU A HB3  1 
ATOM   4877 H HG   . LEU A 1 347 ? -49.725 38.252 15.909  1.00 29.30 ? 313 LEU A HG   1 
ATOM   4878 H HD11 . LEU A 1 347 ? -51.756 37.290 15.309  1.00 31.90 ? 313 LEU A HD11 1 
ATOM   4879 H HD12 . LEU A 1 347 ? -51.974 38.294 16.521  1.00 31.90 ? 313 LEU A HD12 1 
ATOM   4880 H HD13 . LEU A 1 347 ? -52.367 38.732 15.045  1.00 31.90 ? 313 LEU A HD13 1 
ATOM   4881 H HD21 . LEU A 1 347 ? -50.255 37.794 13.573  1.00 33.05 ? 313 LEU A HD21 1 
ATOM   4882 H HD22 . LEU A 1 347 ? -50.312 39.374 13.409  1.00 33.05 ? 313 LEU A HD22 1 
ATOM   4883 H HD23 . LEU A 1 347 ? -48.960 38.670 13.857  1.00 33.05 ? 313 LEU A HD23 1 
ATOM   4884 N N    . GLU A 1 348 ? -47.927 42.948 16.353  1.00 26.39 ? 314 GLU A N    1 
ATOM   4885 C CA   . GLU A 1 348 ? -47.825 44.343 16.750  1.00 26.17 ? 314 GLU A CA   1 
ATOM   4886 C C    . GLU A 1 348 ? -47.750 45.230 15.515  1.00 26.01 ? 314 GLU A C    1 
ATOM   4887 O O    . GLU A 1 348 ? -47.204 44.840 14.479  1.00 27.15 ? 314 GLU A O    1 
ATOM   4888 C CB   . GLU A 1 348 ? -46.587 44.569 17.619  1.00 27.60 ? 314 GLU A CB   1 
ATOM   4889 C CG   . GLU A 1 348 ? -46.585 43.793 18.920  1.00 25.59 ? 314 GLU A CG   1 
ATOM   4890 C CD   . GLU A 1 348 ? -47.644 44.280 19.888  1.00 33.00 ? 314 GLU A CD   1 
ATOM   4891 O OE1  . GLU A 1 348 ? -47.861 45.506 19.962  1.00 28.64 ? 314 GLU A OE1  1 
ATOM   4892 O OE2  . GLU A 1 348 ? -48.259 43.437 20.573  1.00 33.85 ? 314 GLU A OE2  1 
ATOM   4893 H H    . GLU A 1 348 ? -47.196 42.504 16.441  1.00 31.70 ? 314 GLU A H    1 
ATOM   4894 H HA   . GLU A 1 348 ? -48.605 44.591 17.270  1.00 31.43 ? 314 GLU A HA   1 
ATOM   4895 H HB2  . GLU A 1 348 ? -45.803 44.300 17.115  1.00 33.15 ? 314 GLU A HB2  1 
ATOM   4896 H HB3  . GLU A 1 348 ? -46.533 45.512 17.840  1.00 33.15 ? 314 GLU A HB3  1 
ATOM   4897 H HG2  . GLU A 1 348 ? -46.756 42.857 18.732  1.00 30.73 ? 314 GLU A HG2  1 
ATOM   4898 H HG3  . GLU A 1 348 ? -45.719 43.892 19.347  1.00 30.73 ? 314 GLU A HG3  1 
ATOM   4899 N N    . TRP A 1 349 ? -48.308 46.430 15.628  1.00 25.26 ? 315 TRP A N    1 
ATOM   4900 C CA   . TRP A 1 349 ? -48.238 47.411 14.558  1.00 21.72 ? 315 TRP A CA   1 
ATOM   4901 C C    . TRP A 1 349 ? -47.628 48.707 15.075  1.00 22.35 ? 315 TRP A C    1 
ATOM   4902 O O    . TRP A 1 349 ? -47.514 48.937 16.283  1.00 25.88 ? 315 TRP A O    1 
ATOM   4903 C CB   . TRP A 1 349 ? -49.616 47.680 13.944  1.00 23.74 ? 315 TRP A CB   1 
ATOM   4904 C CG   . TRP A 1 349 ? -49.529 48.111 12.508  1.00 22.34 ? 315 TRP A CG   1 
ATOM   4905 C CD1  . TRP A 1 349 ? -50.049 49.246 11.958  1.00 24.41 ? 315 TRP A CD1  1 
ATOM   4906 C CD2  . TRP A 1 349 ? -48.870 47.415 11.441  1.00 23.76 ? 315 TRP A CD2  1 
ATOM   4907 N NE1  . TRP A 1 349 ? -49.758 49.299 10.616  1.00 25.49 ? 315 TRP A NE1  1 
ATOM   4908 C CE2  . TRP A 1 349 ? -49.035 48.187 10.274  1.00 26.46 ? 315 TRP A CE2  1 
ATOM   4909 C CE3  . TRP A 1 349 ? -48.157 46.214 11.361  1.00 26.13 ? 315 TRP A CE3  1 
ATOM   4910 C CZ2  . TRP A 1 349 ? -48.517 47.797 9.042   1.00 26.45 ? 315 TRP A CZ2  1 
ATOM   4911 C CZ3  . TRP A 1 349 ? -47.643 45.830 10.137  1.00 32.03 ? 315 TRP A CZ3  1 
ATOM   4912 C CH2  . TRP A 1 349 ? -47.825 46.619 8.995   1.00 22.35 ? 315 TRP A CH2  1 
ATOM   4913 H H    . TRP A 1 349 ? -48.737 46.699 16.323  1.00 30.34 ? 315 TRP A H    1 
ATOM   4914 H HA   . TRP A 1 349 ? -47.663 47.072 13.854  1.00 26.09 ? 315 TRP A HA   1 
ATOM   4915 H HB2  . TRP A 1 349 ? -50.145 46.868 13.985  1.00 28.51 ? 315 TRP A HB2  1 
ATOM   4916 H HB3  . TRP A 1 349 ? -50.054 48.386 14.445  1.00 28.51 ? 315 TRP A HB3  1 
ATOM   4917 H HD1  . TRP A 1 349 ? -50.532 49.890 12.424  1.00 29.32 ? 315 TRP A HD1  1 
ATOM   4918 H HE1  . TRP A 1 349 ? -49.992 49.929 10.078  1.00 30.62 ? 315 TRP A HE1  1 
ATOM   4919 H HE3  . TRP A 1 349 ? -48.032 45.685 12.115  1.00 31.38 ? 315 TRP A HE3  1 
ATOM   4920 H HZ2  . TRP A 1 349 ? -48.637 48.318 8.281   1.00 31.76 ? 315 TRP A HZ2  1 
ATOM   4921 H HZ3  . TRP A 1 349 ? -47.168 45.033 10.071  1.00 38.47 ? 315 TRP A HZ3  1 
ATOM   4922 H HH2  . TRP A 1 349 ? -47.466 46.335 8.185   1.00 26.84 ? 315 TRP A HH2  1 
ATOM   4923 N N    . TYR A 1 350 ? -47.230 49.554 14.128  1.00 22.60 ? 316 TYR A N    1 
ATOM   4924 C CA   . TYR A 1 350 ? -46.445 50.740 14.401  1.00 20.94 ? 316 TYR A CA   1 
ATOM   4925 C C    . TYR A 1 350 ? -46.897 51.845 13.459  1.00 18.24 ? 316 TYR A C    1 
ATOM   4926 O O    . TYR A 1 350 ? -47.184 51.575 12.283  1.00 21.00 ? 316 TYR A O    1 
ATOM   4927 C CB   . TYR A 1 350 ? -44.950 50.449 14.212  1.00 18.58 ? 316 TYR A CB   1 
ATOM   4928 C CG   . TYR A 1 350 ? -44.470 49.284 15.049  1.00 19.68 ? 316 TYR A CG   1 
ATOM   4929 C CD1  . TYR A 1 350 ? -44.589 47.976 14.591  1.00 23.12 ? 316 TYR A CD1  1 
ATOM   4930 C CD2  . TYR A 1 350 ? -43.913 49.489 16.303  1.00 23.88 ? 316 TYR A CD2  1 
ATOM   4931 C CE1  . TYR A 1 350 ? -44.164 46.908 15.359  1.00 18.59 ? 316 TYR A CE1  1 
ATOM   4932 C CE2  . TYR A 1 350 ? -43.482 48.429 17.076  1.00 20.35 ? 316 TYR A CE2  1 
ATOM   4933 C CZ   . TYR A 1 350 ? -43.609 47.142 16.601  1.00 23.46 ? 316 TYR A CZ   1 
ATOM   4934 O OH   . TYR A 1 350 ? -43.180 46.087 17.374  1.00 17.33 ? 316 TYR A OH   1 
ATOM   4935 H H    . TYR A 1 350 ? -47.411 49.453 13.294  1.00 27.14 ? 316 TYR A H    1 
ATOM   4936 H HA   . TYR A 1 350 ? -46.589 51.045 15.311  1.00 25.15 ? 316 TYR A HA   1 
ATOM   4937 H HB2  . TYR A 1 350 ? -44.785 50.238 13.280  1.00 22.32 ? 316 TYR A HB2  1 
ATOM   4938 H HB3  . TYR A 1 350 ? -44.441 51.234 14.470  1.00 22.32 ? 316 TYR A HB3  1 
ATOM   4939 H HD1  . TYR A 1 350 ? -44.962 47.817 13.754  1.00 27.77 ? 316 TYR A HD1  1 
ATOM   4940 H HD2  . TYR A 1 350 ? -43.829 50.356 16.629  1.00 28.69 ? 316 TYR A HD2  1 
ATOM   4941 H HE1  . TYR A 1 350 ? -44.250 46.038 15.041  1.00 22.33 ? 316 TYR A HE1  1 
ATOM   4942 H HE2  . TYR A 1 350 ? -43.108 48.583 17.913  1.00 24.45 ? 316 TYR A HE2  1 
ATOM   4943 H HH   . TYR A 1 350 ? -43.416 45.361 17.025  1.00 20.82 ? 316 TYR A HH   1 
ATOM   4944 N N    . PRO A 1 351 ? -46.978 53.091 13.934  1.00 21.98 ? 317 PRO A N    1 
ATOM   4945 C CA   . PRO A 1 351 ? -47.456 54.165 13.049  1.00 21.03 ? 317 PRO A CA   1 
ATOM   4946 C C    . PRO A 1 351 ? -46.573 54.367 11.832  1.00 19.71 ? 317 PRO A C    1 
ATOM   4947 O O    . PRO A 1 351 ? -47.072 54.759 10.770  1.00 19.56 ? 317 PRO A O    1 
ATOM   4948 C CB   . PRO A 1 351 ? -47.464 55.398 13.964  1.00 24.41 ? 317 PRO A CB   1 
ATOM   4949 C CG   . PRO A 1 351 ? -46.480 55.087 15.036  1.00 21.34 ? 317 PRO A CG   1 
ATOM   4950 C CD   . PRO A 1 351 ? -46.556 53.603 15.250  1.00 24.09 ? 317 PRO A CD   1 
ATOM   4951 H HA   . PRO A 1 351 ? -48.364 53.983 12.759  1.00 25.26 ? 317 PRO A HA   1 
ATOM   4952 H HB2  . PRO A 1 351 ? -47.194 56.183 13.462  1.00 29.32 ? 317 PRO A HB2  1 
ATOM   4953 H HB3  . PRO A 1 351 ? -48.351 55.529 14.334  1.00 29.32 ? 317 PRO A HB3  1 
ATOM   4954 H HG2  . PRO A 1 351 ? -45.591 55.347 14.749  1.00 25.64 ? 317 PRO A HG2  1 
ATOM   4955 H HG3  . PRO A 1 351 ? -46.719 55.563 15.847  1.00 25.64 ? 317 PRO A HG3  1 
ATOM   4956 H HD2  . PRO A 1 351 ? -45.689 53.245 15.497  1.00 28.93 ? 317 PRO A HD2  1 
ATOM   4957 H HD3  . PRO A 1 351 ? -47.211 53.385 15.931  1.00 28.93 ? 317 PRO A HD3  1 
ATOM   4958 N N    . GLU A 1 352 ? -45.271 54.096 11.952  1.00 20.89 ? 318 GLU A N    1 
ATOM   4959 C CA   . GLU A 1 352 ? -44.372 54.256 10.816  1.00 21.30 ? 318 GLU A CA   1 
ATOM   4960 C C    . GLU A 1 352 ? -44.812 53.412 9.627   1.00 23.58 ? 318 GLU A C    1 
ATOM   4961 O O    . GLU A 1 352 ? -44.598 53.806 8.474   1.00 21.22 ? 318 GLU A O    1 
ATOM   4962 C CB   . GLU A 1 352 ? -42.946 53.887 11.226  1.00 18.29 ? 318 GLU A CB   1 
ATOM   4963 C CG   . GLU A 1 352 ? -42.295 54.889 12.166  1.00 19.77 ? 318 GLU A CG   1 
ATOM   4964 C CD   . GLU A 1 352 ? -42.507 54.551 13.632  1.00 23.91 ? 318 GLU A CD   1 
ATOM   4965 O OE1  . GLU A 1 352 ? -43.371 53.700 13.936  1.00 20.91 ? 318 GLU A OE1  1 
ATOM   4966 O OE2  . GLU A 1 352 ? -41.806 55.139 14.483  1.00 23.92 ? 318 GLU A OE2  1 
ATOM   4967 H H    . GLU A 1 352 ? -44.890 53.822 12.673  1.00 25.10 ? 318 GLU A H    1 
ATOM   4968 H HA   . GLU A 1 352 ? -44.379 55.186 10.540  1.00 25.59 ? 318 GLU A HA   1 
ATOM   4969 H HB2  . GLU A 1 352 ? -42.965 53.028 11.677  1.00 21.97 ? 318 GLU A HB2  1 
ATOM   4970 H HB3  . GLU A 1 352 ? -42.397 53.831 10.428  1.00 21.97 ? 318 GLU A HB3  1 
ATOM   4971 H HG2  . GLU A 1 352 ? -41.339 54.903 11.998  1.00 23.75 ? 318 GLU A HG2  1 
ATOM   4972 H HG3  . GLU A 1 352 ? -42.674 55.766 12.004  1.00 23.75 ? 318 GLU A HG3  1 
ATOM   4973 N N    . LEU A 1 353 ? -45.425 52.257 9.881   1.00 18.73 ? 319 LEU A N    1 
ATOM   4974 C CA   . LEU A 1 353 ? -45.846 51.357 8.817   1.00 18.42 ? 319 LEU A CA   1 
ATOM   4975 C C    . LEU A 1 353 ? -47.189 51.741 8.210   1.00 19.47 ? 319 LEU A C    1 
ATOM   4976 O O    . LEU A 1 353 ? -47.642 51.068 7.278   1.00 23.17 ? 319 LEU A O    1 
ATOM   4977 C CB   . LEU A 1 353 ? -45.904 49.922 9.347   1.00 20.48 ? 319 LEU A CB   1 
ATOM   4978 C CG   . LEU A 1 353 ? -44.613 49.429 10.006  1.00 19.45 ? 319 LEU A CG   1 
ATOM   4979 C CD1  . LEU A 1 353 ? -44.783 48.015 10.539  1.00 17.54 ? 319 LEU A CD1  1 
ATOM   4980 C CD2  . LEU A 1 353 ? -43.442 49.492 9.035   1.00 17.62 ? 319 LEU A CD2  1 
ATOM   4981 H H    . LEU A 1 353 ? -45.608 51.971 10.671  1.00 22.50 ? 319 LEU A H    1 
ATOM   4982 H HA   . LEU A 1 353 ? -45.188 51.385 8.104   1.00 22.13 ? 319 LEU A HA   1 
ATOM   4983 H HB2  . LEU A 1 353 ? -46.610 49.868 10.010  1.00 24.60 ? 319 LEU A HB2  1 
ATOM   4984 H HB3  . LEU A 1 353 ? -46.099 49.328 8.605   1.00 24.60 ? 319 LEU A HB3  1 
ATOM   4985 H HG   . LEU A 1 353 ? -44.411 50.012 10.755  1.00 23.36 ? 319 LEU A HG   1 
ATOM   4986 H HD11 . LEU A 1 353 ? -43.996 47.774 11.051  1.00 21.07 ? 319 LEU A HD11 1 
ATOM   4987 H HD12 . LEU A 1 353 ? -45.569 47.984 11.106  1.00 21.07 ? 319 LEU A HD12 1 
ATOM   4988 H HD13 . LEU A 1 353 ? -44.891 47.407 9.791   1.00 21.07 ? 319 LEU A HD13 1 
ATOM   4989 H HD21 . LEU A 1 353 ? -42.653 49.131 9.468   1.00 21.17 ? 319 LEU A HD21 1 
ATOM   4990 H HD22 . LEU A 1 353 ? -43.657 48.968 8.247   1.00 21.17 ? 319 LEU A HD22 1 
ATOM   4991 H HD23 . LEU A 1 353 ? -43.288 50.417 8.785   1.00 21.17 ? 319 LEU A HD23 1 
ATOM   4992 N N    . ASP A 1 354 ? -47.833 52.796 8.712   1.00 23.45 ? 320 ASP A N    1 
ATOM   4993 C CA   . ASP A 1 354 ? -49.051 53.329 8.118   1.00 22.77 ? 320 ASP A CA   1 
ATOM   4994 C C    . ASP A 1 354 ? -48.813 54.606 7.324   1.00 23.84 ? 320 ASP A C    1 
ATOM   4995 O O    . ASP A 1 354 ? -49.710 55.039 6.593   1.00 28.28 ? 320 ASP A O    1 
ATOM   4996 C CB   . ASP A 1 354 ? -50.097 53.612 9.206   1.00 30.04 ? 320 ASP A CB   1 
ATOM   4997 C CG   . ASP A 1 354 ? -50.774 52.354 9.710   1.00 23.09 ? 320 ASP A CG   1 
ATOM   4998 O OD1  . ASP A 1 354 ? -50.967 51.414 8.912   1.00 22.37 ? 320 ASP A OD1  1 
ATOM   4999 O OD2  . ASP A 1 354 ? -51.116 52.308 10.909  1.00 31.24 ? 320 ASP A OD2  1 
ATOM   5000 H H    . ASP A 1 354 ? -47.575 53.227 9.410   1.00 28.17 ? 320 ASP A H    1 
ATOM   5001 H HA   . ASP A 1 354 ? -49.417 52.660 7.518   1.00 27.35 ? 320 ASP A HA   1 
ATOM   5002 H HB2  . ASP A 1 354 ? -49.661 54.040 9.959   1.00 36.07 ? 320 ASP A HB2  1 
ATOM   5003 H HB3  . ASP A 1 354 ? -50.781 54.196 8.842   1.00 36.07 ? 320 ASP A HB3  1 
ATOM   5004 N N    . LYS A 1 355 ? -47.640 55.216 7.450   1.00 20.66 ? 321 LYS A N    1 
ATOM   5005 C CA   . LYS A 1 355 ? -47.377 56.489 6.802   1.00 23.70 ? 321 LYS A CA   1 
ATOM   5006 C C    . LYS A 1 355 ? -47.141 56.296 5.309   1.00 18.72 ? 321 LYS A C    1 
ATOM   5007 O O    . LYS A 1 355 ? -46.640 55.260 4.863   1.00 20.67 ? 321 LYS A O    1 
ATOM   5008 C CB   . LYS A 1 355 ? -46.172 57.171 7.446   1.00 21.01 ? 321 LYS A CB   1 
ATOM   5009 C CG   . LYS A 1 355 ? -46.476 57.764 8.815   1.00 27.76 ? 321 LYS A CG   1 
ATOM   5010 C CD   . LYS A 1 355 ? -45.782 59.097 9.018   1.00 33.97 ? 321 LYS A CD   1 
ATOM   5011 C CE   . LYS A 1 355 ? -46.532 60.234 8.344   1.00 29.70 ? 321 LYS A CE   1 
ATOM   5012 N NZ   . LYS A 1 355 ? -47.294 61.052 9.326   1.00 37.49 ? 321 LYS A NZ   1 
ATOM   5013 H H    . LYS A 1 355 ? -46.979 54.911 7.908   1.00 24.82 ? 321 LYS A H    1 
ATOM   5014 H HA   . LYS A 1 355 ? -48.144 57.073 6.905   1.00 28.46 ? 321 LYS A HA   1 
ATOM   5015 H HB2  . LYS A 1 355 ? -45.463 56.518 7.555   1.00 25.24 ? 321 LYS A HB2  1 
ATOM   5016 H HB3  . LYS A 1 355 ? -45.873 57.891 6.869   1.00 25.24 ? 321 LYS A HB3  1 
ATOM   5017 H HG2  . LYS A 1 355 ? -47.432 57.904 8.898   1.00 33.34 ? 321 LYS A HG2  1 
ATOM   5018 H HG3  . LYS A 1 355 ? -46.169 57.154 9.503   1.00 33.34 ? 321 LYS A HG3  1 
ATOM   5019 H HD2  . LYS A 1 355 ? -45.729 59.289 9.967   1.00 40.79 ? 321 LYS A HD2  1 
ATOM   5020 H HD3  . LYS A 1 355 ? -44.890 59.054 8.638   1.00 40.79 ? 321 LYS A HD3  1 
ATOM   5021 H HE2  . LYS A 1 355 ? -45.897 60.813 7.894   1.00 35.67 ? 321 LYS A HE2  1 
ATOM   5022 H HE3  . LYS A 1 355 ? -47.160 59.868 7.702   1.00 35.67 ? 321 LYS A HE3  1 
ATOM   5023 H HZ1  . LYS A 1 355 ? -47.672 61.745 8.916   1.00 45.01 ? 321 LYS A HZ1  1 
ATOM   5024 H HZ2  . LYS A 1 355 ? -47.930 60.558 9.705   1.00 45.01 ? 321 LYS A HZ2  1 
ATOM   5025 H HZ3  . LYS A 1 355 ? -46.747 61.354 9.960   1.00 45.01 ? 321 LYS A HZ3  1 
ATOM   5026 N N    . SER A 1 356 ? -47.518 57.310 4.535   1.00 19.22 ? 322 SER A N    1 
ATOM   5027 C CA   . SER A 1 356 ? -47.353 57.254 3.091   1.00 18.47 ? 322 SER A CA   1 
ATOM   5028 C C    . SER A 1 356 ? -45.873 57.306 2.734   1.00 21.86 ? 322 SER A C    1 
ATOM   5029 O O    . SER A 1 356 ? -45.145 58.194 3.187   1.00 19.24 ? 322 SER A O    1 
ATOM   5030 C CB   . SER A 1 356 ? -48.100 58.410 2.429   1.00 23.39 ? 322 SER A CB   1 
ATOM   5031 O OG   . SER A 1 356 ? -47.702 58.565 1.079   1.00 25.11 ? 322 SER A OG   1 
ATOM   5032 H H    . SER A 1 356 ? -47.870 58.040 4.824   1.00 23.09 ? 322 SER A H    1 
ATOM   5033 H HA   . SER A 1 356 ? -47.722 56.424 2.753   1.00 22.19 ? 322 SER A HA   1 
ATOM   5034 H HB2  . SER A 1 356 ? -49.052 58.227 2.458   1.00 28.10 ? 322 SER A HB2  1 
ATOM   5035 H HB3  . SER A 1 356 ? -47.905 59.228 2.911   1.00 28.10 ? 322 SER A HB3  1 
ATOM   5036 H HG   . SER A 1 356 ? -47.872 57.865 0.647   1.00 30.16 ? 322 SER A HG   1 
ATOM   5037 N N    . LEU A 1 357 ? -45.431 56.347 1.921   1.00 21.93 ? 323 LEU A N    1 
ATOM   5038 C CA   . LEU A 1 357 ? -44.034 56.236 1.523   1.00 18.54 ? 323 LEU A CA   1 
ATOM   5039 C C    . LEU A 1 357 ? -43.831 56.637 0.067   1.00 22.47 ? 323 LEU A C    1 
ATOM   5040 O O    . LEU A 1 357 ? -43.129 57.613 -0.214  1.00 16.35 ? 323 LEU A O    1 
ATOM   5041 C CB   . LEU A 1 357 ? -43.542 54.801 1.769   1.00 22.40 ? 323 LEU A CB   1 
ATOM   5042 C CG   . LEU A 1 357 ? -42.129 54.429 1.312   1.00 19.54 ? 323 LEU A CG   1 
ATOM   5043 C CD1  . LEU A 1 357 ? -41.075 55.158 2.131   1.00 18.23 ? 323 LEU A CD1  1 
ATOM   5044 C CD2  . LEU A 1 357 ? -41.932 52.925 1.410   1.00 20.17 ? 323 LEU A CD2  1 
ATOM   5045 H H    . LEU A 1 357 ? -45.933 55.737 1.582   1.00 26.35 ? 323 LEU A H    1 
ATOM   5046 H HA   . LEU A 1 357 ? -43.496 56.834 2.066   1.00 22.27 ? 323 LEU A HA   1 
ATOM   5047 H HB2  . LEU A 1 357 ? -43.576 54.639 2.725   1.00 26.91 ? 323 LEU A HB2  1 
ATOM   5048 H HB3  . LEU A 1 357 ? -44.149 54.200 1.310   1.00 26.91 ? 323 LEU A HB3  1 
ATOM   5049 H HG   . LEU A 1 357 ? -42.017 54.700 0.387   1.00 23.48 ? 323 LEU A HG   1 
ATOM   5050 H HD11 . LEU A 1 357 ? -40.196 54.859 1.851   1.00 21.91 ? 323 LEU A HD11 1 
ATOM   5051 H HD12 . LEU A 1 357 ? -41.164 56.112 1.981   1.00 21.91 ? 323 LEU A HD12 1 
ATOM   5052 H HD13 . LEU A 1 357 ? -41.210 54.956 3.070   1.00 21.91 ? 323 LEU A HD13 1 
ATOM   5053 H HD21 . LEU A 1 357 ? -41.016 52.711 1.173   1.00 24.23 ? 323 LEU A HD21 1 
ATOM   5054 H HD22 . LEU A 1 357 ? -42.113 52.642 2.319   1.00 24.23 ? 323 LEU A HD22 1 
ATOM   5055 H HD23 . LEU A 1 357 ? -42.543 52.486 0.798   1.00 24.23 ? 323 LEU A HD23 1 
ATOM   5056 N N    . GLY A 1 358 ? -44.442 55.918 -0.869  1.00 20.23 ? 324 GLY A N    1 
ATOM   5057 C CA   . GLY A 1 358 ? -44.283 56.201 -2.278  1.00 19.64 ? 324 GLY A CA   1 
ATOM   5058 C C    . GLY A 1 358 ? -43.051 55.540 -2.870  1.00 20.76 ? 324 GLY A C    1 
ATOM   5059 O O    . GLY A 1 358 ? -42.236 54.922 -2.181  1.00 20.72 ? 324 GLY A O    1 
ATOM   5060 H H    . GLY A 1 358 ? -44.960 55.251 -0.704  1.00 24.30 ? 324 GLY A H    1 
ATOM   5061 H HA2  . GLY A 1 358 ? -45.062 55.881 -2.759  1.00 23.59 ? 324 GLY A HA2  1 
ATOM   5062 H HA3  . GLY A 1 358 ? -44.206 57.160 -2.405  1.00 23.59 ? 324 GLY A HA3  1 
ATOM   5063 N N    . LYS A 1 359 ? -42.918 55.683 -4.188  1.00 16.98 ? 325 LYS A N    1 
ATOM   5064 C CA   . LYS A 1 359 ? -41.838 55.021 -4.901  1.00 20.31 ? 325 LYS A CA   1 
ATOM   5065 C C    . LYS A 1 359 ? -40.497 55.677 -4.576  1.00 19.94 ? 325 LYS A C    1 
ATOM   5066 O O    . LYS A 1 359 ? -40.436 56.877 -4.290  1.00 15.18 ? 325 LYS A O    1 
ATOM   5067 C CB   . LYS A 1 359 ? -42.059 55.076 -6.413  1.00 24.56 ? 325 LYS A CB   1 
ATOM   5068 C CG   . LYS A 1 359 ? -43.474 54.766 -6.889  1.00 30.37 ? 325 LYS A CG   1 
ATOM   5069 C CD   . LYS A 1 359 ? -43.924 55.765 -7.953  1.00 45.59 ? 325 LYS A CD   1 
ATOM   5070 C CE   . LYS A 1 359 ? -45.435 55.775 -8.137  1.00 48.82 ? 325 LYS A CE   1 
ATOM   5071 N NZ   . LYS A 1 359 ? -46.177 56.013 -6.864  1.00 38.47 ? 325 LYS A NZ   1 
ATOM   5072 H H    . LYS A 1 359 ? -43.437 56.155 -4.685  1.00 20.40 ? 325 LYS A H    1 
ATOM   5073 H HA   . LYS A 1 359 ? -41.812 54.091 -4.628  1.00 24.40 ? 325 LYS A HA   1 
ATOM   5074 H HB2  . LYS A 1 359 ? -41.843 55.970 -6.719  1.00 29.50 ? 325 LYS A HB2  1 
ATOM   5075 H HB3  . LYS A 1 359 ? -41.468 54.429 -6.830  1.00 29.50 ? 325 LYS A HB3  1 
ATOM   5076 H HG2  . LYS A 1 359 ? -43.498 53.876 -7.274  1.00 36.48 ? 325 LYS A HG2  1 
ATOM   5077 H HG3  . LYS A 1 359 ? -44.087 54.820 -6.139  1.00 36.48 ? 325 LYS A HG3  1 
ATOM   5078 H HD2  . LYS A 1 359 ? -43.647 56.656 -7.690  1.00 54.74 ? 325 LYS A HD2  1 
ATOM   5079 H HD3  . LYS A 1 359 ? -43.519 55.529 -8.802  1.00 54.74 ? 325 LYS A HD3  1 
ATOM   5080 H HE2  . LYS A 1 359 ? -45.673 56.482 -8.757  1.00 58.61 ? 325 LYS A HE2  1 
ATOM   5081 H HE3  . LYS A 1 359 ? -45.716 54.916 -8.490  1.00 58.61 ? 325 LYS A HE3  1 
ATOM   5082 H HZ1  . LYS A 1 359 ? -47.049 56.084 -7.029  1.00 46.19 ? 325 LYS A HZ1  1 
ATOM   5083 H HZ2  . LYS A 1 359 ? -46.043 55.335 -6.303  1.00 46.19 ? 325 LYS A HZ2  1 
ATOM   5084 H HZ3  . LYS A 1 359 ? -45.892 56.765 -6.482  1.00 46.19 ? 325 LYS A HZ3  1 
ATOM   5085 N N    . PRO A 1 360 ? -39.405 54.915 -4.622  1.00 18.34 ? 326 PRO A N    1 
ATOM   5086 C CA   . PRO A 1 360 ? -38.083 55.536 -4.495  1.00 19.14 ? 326 PRO A CA   1 
ATOM   5087 C C    . PRO A 1 360 ? -37.843 56.521 -5.628  1.00 16.93 ? 326 PRO A C    1 
ATOM   5088 O O    . PRO A 1 360 ? -38.265 56.303 -6.765  1.00 18.99 ? 326 PRO A O    1 
ATOM   5089 C CB   . PRO A 1 360 ? -37.113 54.349 -4.561  1.00 19.38 ? 326 PRO A CB   1 
ATOM   5090 C CG   . PRO A 1 360 ? -37.897 53.205 -5.085  1.00 19.21 ? 326 PRO A CG   1 
ATOM   5091 C CD   . PRO A 1 360 ? -39.328 53.451 -4.749  1.00 19.30 ? 326 PRO A CD   1 
ATOM   5092 H HA   . PRO A 1 360 ? -37.987 55.980 -3.638  1.00 23.00 ? 326 PRO A HA   1 
ATOM   5093 H HB2  . PRO A 1 360 ? -36.378 54.563 -5.156  1.00 23.29 ? 326 PRO A HB2  1 
ATOM   5094 H HB3  . PRO A 1 360 ? -36.776 54.155 -3.672  1.00 23.29 ? 326 PRO A HB3  1 
ATOM   5095 H HG2  . PRO A 1 360 ? -37.780 53.151 -6.047  1.00 23.08 ? 326 PRO A HG2  1 
ATOM   5096 H HG3  . PRO A 1 360 ? -37.587 52.386 -4.667  1.00 23.08 ? 326 PRO A HG3  1 
ATOM   5097 H HD2  . PRO A 1 360 ? -39.908 53.136 -5.461  1.00 23.19 ? 326 PRO A HD2  1 
ATOM   5098 H HD3  . PRO A 1 360 ? -39.565 53.019 -3.913  1.00 23.19 ? 326 PRO A HD3  1 
ATOM   5099 N N    . LEU A 1 361 ? -37.164 57.618 -5.304  1.00 19.61 ? 327 LEU A N    1 
ATOM   5100 C CA   . LEU A 1 361 ? -36.827 58.628 -6.297  1.00 22.32 ? 327 LEU A CA   1 
ATOM   5101 C C    . LEU A 1 361 ? -35.390 58.525 -6.788  1.00 28.09 ? 327 LEU A C    1 
ATOM   5102 O O    . LEU A 1 361 ? -35.092 59.009 -7.886  1.00 22.49 ? 327 LEU A O    1 
ATOM   5103 C CB   . LEU A 1 361 ? -37.064 60.030 -5.724  1.00 17.92 ? 327 LEU A CB   1 
ATOM   5104 C CG   . LEU A 1 361 ? -38.527 60.382 -5.437  1.00 21.93 ? 327 LEU A CG   1 
ATOM   5105 C CD1  . LEU A 1 361 ? -38.631 61.769 -4.822  1.00 27.40 ? 327 LEU A CD1  1 
ATOM   5106 C CD2  . LEU A 1 361 ? -39.373 60.288 -6.700  1.00 20.77 ? 327 LEU A CD2  1 
ATOM   5107 H H    . LEU A 1 361 ? -36.886 57.800 -4.511  1.00 23.56 ? 327 LEU A H    1 
ATOM   5108 H HA   . LEU A 1 361 ? -37.409 58.520 -7.065  1.00 26.81 ? 327 LEU A HA   1 
ATOM   5109 H HB2  . LEU A 1 361 ? -36.579 60.103 -4.887  1.00 21.53 ? 327 LEU A HB2  1 
ATOM   5110 H HB3  . LEU A 1 361 ? -36.729 60.680 -6.360  1.00 21.53 ? 327 LEU A HB3  1 
ATOM   5111 H HG   . LEU A 1 361 ? -38.880 59.741 -4.801  1.00 26.34 ? 327 LEU A HG   1 
ATOM   5112 H HD11 . LEU A 1 361 ? -39.567 62.004 -4.730  1.00 32.90 ? 327 LEU A HD11 1 
ATOM   5113 H HD12 . LEU A 1 361 ? -38.205 61.760 -3.950  1.00 32.90 ? 327 LEU A HD12 1 
ATOM   5114 H HD13 . LEU A 1 361 ? -38.184 62.406 -5.401  1.00 32.90 ? 327 LEU A HD13 1 
ATOM   5115 H HD21 . LEU A 1 361 ? -40.244 60.677 -6.526  1.00 24.96 ? 327 LEU A HD21 1 
ATOM   5116 H HD22 . LEU A 1 361 ? -38.931 60.775 -7.413  1.00 24.96 ? 327 LEU A HD22 1 
ATOM   5117 H HD23 . LEU A 1 361 ? -39.470 59.355 -6.947  1.00 24.96 ? 327 LEU A HD23 1 
ATOM   5118 N N    . ASN A 1 362 ? -34.502 57.902 -6.017  1.00 23.08 ? 328 ASN A N    1 
ATOM   5119 C CA   . ASN A 1 362 ? -33.105 57.762 -6.397  1.00 22.17 ? 328 ASN A CA   1 
ATOM   5120 C C    . ASN A 1 362 ? -32.611 56.391 -5.959  1.00 19.13 ? 328 ASN A C    1 
ATOM   5121 O O    . ASN A 1 362 ? -33.369 55.572 -5.431  1.00 17.42 ? 328 ASN A O    1 
ATOM   5122 C CB   . ASN A 1 362 ? -32.250 58.876 -5.779  1.00 21.87 ? 328 ASN A CB   1 
ATOM   5123 C CG   . ASN A 1 362 ? -32.285 58.864 -4.259  1.00 26.93 ? 328 ASN A CG   1 
ATOM   5124 O OD1  . ASN A 1 362 ? -32.901 57.993 -3.644  1.00 23.80 ? 328 ASN A OD1  1 
ATOM   5125 N ND2  . ASN A 1 362 ? -31.619 59.836 -3.647  1.00 29.89 ? 328 ASN A ND2  1 
ATOM   5126 H H    . ASN A 1 362 ? -34.691 57.546 -5.257  1.00 27.72 ? 328 ASN A H    1 
ATOM   5127 H HA   . ASN A 1 362 ? -33.036 57.820 -7.363  1.00 26.63 ? 328 ASN A HA   1 
ATOM   5128 H HB2  . ASN A 1 362 ? -31.329 58.760 -6.059  1.00 26.27 ? 328 ASN A HB2  1 
ATOM   5129 H HB3  . ASN A 1 362 ? -32.583 59.735 -6.080  1.00 26.27 ? 328 ASN A HB3  1 
ATOM   5130 H HD21 . ASN A 1 362 ? -31.607 59.874 -2.788  1.00 35.90 ? 328 ASN A HD21 1 
ATOM   5131 H HD22 . ASN A 1 362 ? -31.199 60.427 -4.110  1.00 35.90 ? 328 ASN A HD22 1 
ATOM   5132 N N    . GLU A 1 363 ? -31.329 56.143 -6.194  1.00 18.97 ? 329 GLU A N    1 
ATOM   5133 C CA   . GLU A 1 363 ? -30.661 54.957 -5.686  1.00 23.52 ? 329 GLU A CA   1 
ATOM   5134 C C    . GLU A 1 363 ? -30.087 55.247 -4.305  1.00 19.11 ? 329 GLU A C    1 
ATOM   5135 O O    . GLU A 1 363 ? -29.892 56.401 -3.918  1.00 17.32 ? 329 GLU A O    1 
ATOM   5136 C CB   . GLU A 1 363 ? -29.541 54.511 -6.627  1.00 23.30 ? 329 GLU A CB   1 
ATOM   5137 C CG   . GLU A 1 363 ? -29.945 54.401 -8.089  1.00 31.23 ? 329 GLU A CG   1 
ATOM   5138 C CD   . GLU A 1 363 ? -30.381 53.004 -8.467  1.00 40.43 ? 329 GLU A CD   1 
ATOM   5139 O OE1  . GLU A 1 363 ? -30.634 52.193 -7.552  1.00 42.76 ? 329 GLU A OE1  1 
ATOM   5140 O OE2  . GLU A 1 363 ? -30.464 52.714 -9.680  1.00 51.07 ? 329 GLU A OE2  1 
ATOM   5141 H H    . GLU A 1 363 ? -30.816 56.658 -6.653  1.00 22.79 ? 329 GLU A H    1 
ATOM   5142 H HA   . GLU A 1 363 ? -31.299 54.229 -5.622  1.00 28.25 ? 329 GLU A HA   1 
ATOM   5143 H HB2  . GLU A 1 363 ? -28.818 55.154 -6.571  1.00 27.99 ? 329 GLU A HB2  1 
ATOM   5144 H HB3  . GLU A 1 363 ? -29.231 53.636 -6.344  1.00 27.99 ? 329 GLU A HB3  1 
ATOM   5145 H HG2  . GLU A 1 363 ? -30.685 55.004 -8.259  1.00 37.50 ? 329 GLU A HG2  1 
ATOM   5146 H HG3  . GLU A 1 363 ? -29.187 54.641 -8.645  1.00 37.50 ? 329 GLU A HG3  1 
ATOM   5147 N N    . MET A 1 364 ? -29.815 54.180 -3.560  1.00 16.55 ? 330 MET A N    1 
ATOM   5148 C CA   . MET A 1 364 ? -29.200 54.345 -2.251  1.00 18.46 ? 330 MET A CA   1 
ATOM   5149 C C    . MET A 1 364 ? -27.859 55.048 -2.403  1.00 17.39 ? 330 MET A C    1 
ATOM   5150 O O    . MET A 1 364 ? -27.068 54.720 -3.292  1.00 17.09 ? 330 MET A O    1 
ATOM   5151 C CB   . MET A 1 364 ? -29.014 52.992 -1.569  1.00 17.64 ? 330 MET A CB   1 
ATOM   5152 C CG   . MET A 1 364 ? -28.360 53.094 -0.202  1.00 19.62 ? 330 MET A CG   1 
ATOM   5153 S SD   . MET A 1 364 ? -28.368 51.537 0.700   1.00 17.11 ? 330 MET A SD   1 
ATOM   5154 C CE   . MET A 1 364 ? -26.915 50.754 0.006   1.00 16.67 ? 330 MET A CE   1 
ATOM   5155 H H    . MET A 1 364 ? -29.974 53.365 -3.786  1.00 19.88 ? 330 MET A H    1 
ATOM   5156 H HA   . MET A 1 364 ? -29.787 54.873 -1.688  1.00 22.18 ? 330 MET A HA   1 
ATOM   5157 H HB2  . MET A 1 364 ? -29.883 52.576 -1.454  1.00 21.19 ? 330 MET A HB2  1 
ATOM   5158 H HB3  . MET A 1 364 ? -28.451 52.434 -2.128  1.00 21.19 ? 330 MET A HB3  1 
ATOM   5159 H HG2  . MET A 1 364 ? -27.436 53.369 -0.314  1.00 23.57 ? 330 MET A HG2  1 
ATOM   5160 H HG3  . MET A 1 364 ? -28.839 53.749 0.329   1.00 23.57 ? 330 MET A HG3  1 
ATOM   5161 H HE1  . MET A 1 364 ? -26.799 49.883 0.416   1.00 20.03 ? 330 MET A HE1  1 
ATOM   5162 H HE2  . MET A 1 364 ? -27.037 50.655 -0.951  1.00 20.03 ? 330 MET A HE2  1 
ATOM   5163 H HE3  . MET A 1 364 ? -26.141 51.310 0.185   1.00 20.03 ? 330 MET A HE3  1 
ATOM   5164 N N    . LYS A 1 365 ? -27.615 56.030 -1.545  1.00 17.96 ? 331 LYS A N    1 
ATOM   5165 C CA   . LYS A 1 365 ? -26.360 56.764 -1.526  1.00 23.17 ? 331 LYS A CA   1 
ATOM   5166 C C    . LYS A 1 365 ? -25.555 56.344 -0.306  1.00 21.78 ? 331 LYS A C    1 
ATOM   5167 O O    . LYS A 1 365 ? -26.119 56.080 0.762   1.00 16.92 ? 331 LYS A O    1 
ATOM   5168 C CB   . LYS A 1 365 ? -26.602 58.275 -1.508  1.00 22.26 ? 331 LYS A CB   1 
ATOM   5169 C CG   . LYS A 1 365 ? -26.477 58.939 -2.871  1.00 33.18 ? 331 LYS A CG   1 
ATOM   5170 C CD   . LYS A 1 365 ? -27.802 58.936 -3.610  1.00 33.49 ? 331 LYS A CD   1 
ATOM   5171 C CE   . LYS A 1 365 ? -27.634 59.335 -5.069  1.00 40.18 ? 331 LYS A CE   1 
ATOM   5172 N NZ   . LYS A 1 365 ? -28.443 58.474 -5.977  1.00 41.67 ? 331 LYS A NZ   1 
ATOM   5173 H H    . LYS A 1 365 ? -28.176 56.295 -0.950  1.00 21.58 ? 331 LYS A H    1 
ATOM   5174 H HA   . LYS A 1 365 ? -25.845 56.559 -2.322  1.00 27.83 ? 331 LYS A HA   1 
ATOM   5175 H HB2  . LYS A 1 365 ? -27.499 58.442 -1.180  1.00 26.74 ? 331 LYS A HB2  1 
ATOM   5176 H HB3  . LYS A 1 365 ? -25.950 58.687 -0.919  1.00 26.74 ? 331 LYS A HB3  1 
ATOM   5177 H HG2  . LYS A 1 365 ? -26.194 59.860 -2.756  1.00 39.84 ? 331 LYS A HG2  1 
ATOM   5178 H HG3  . LYS A 1 365 ? -25.828 58.457 -3.406  1.00 39.84 ? 331 LYS A HG3  1 
ATOM   5179 H HD2  . LYS A 1 365 ? -28.183 58.044 -3.581  1.00 40.21 ? 331 LYS A HD2  1 
ATOM   5180 H HD3  . LYS A 1 365 ? -28.406 59.568 -3.190  1.00 40.21 ? 331 LYS A HD3  1 
ATOM   5181 H HE2  . LYS A 1 365 ? -27.923 60.254 -5.184  1.00 48.25 ? 331 LYS A HE2  1 
ATOM   5182 H HE3  . LYS A 1 365 ? -26.701 59.246 -5.319  1.00 48.25 ? 331 LYS A HE3  1 
ATOM   5183 H HZ1  . LYS A 1 365 ? -28.348 58.746 -6.819  1.00 50.04 ? 331 LYS A HZ1  1 
ATOM   5184 H HZ2  . LYS A 1 365 ? -28.174 57.628 -5.914  1.00 50.04 ? 331 LYS A HZ2  1 
ATOM   5185 H HZ3  . LYS A 1 365 ? -29.304 58.521 -5.753  1.00 50.04 ? 331 LYS A HZ3  1 
ATOM   5186 N N    . VAL A 1 366 ? -24.239 56.271 -0.473  1.00 19.75 ? 332 VAL A N    1 
ATOM   5187 C CA   . VAL A 1 366 ? -23.333 55.826 0.575   1.00 19.04 ? 332 VAL A CA   1 
ATOM   5188 C C    . VAL A 1 366 ? -22.269 56.896 0.757   1.00 21.63 ? 332 VAL A C    1 
ATOM   5189 O O    . VAL A 1 366 ? -21.491 57.167 -0.166  1.00 16.73 ? 332 VAL A O    1 
ATOM   5190 C CB   . VAL A 1 366 ? -22.686 54.471 0.243   1.00 19.05 ? 332 VAL A CB   1 
ATOM   5191 C CG1  . VAL A 1 366 ? -21.811 54.002 1.397   1.00 23.40 ? 332 VAL A CG1  1 
ATOM   5192 C CG2  . VAL A 1 366 ? -23.756 53.437 -0.080  1.00 27.11 ? 332 VAL A CG2  1 
ATOM   5193 H H    . VAL A 1 366 ? -23.839 56.480 -1.205  1.00 23.73 ? 332 VAL A H    1 
ATOM   5194 H HA   . VAL A 1 366 ? -23.822 55.735 1.407   1.00 22.87 ? 332 VAL A HA   1 
ATOM   5195 H HB   . VAL A 1 366 ? -22.122 54.574 -0.540  1.00 22.89 ? 332 VAL A HB   1 
ATOM   5196 H HG11 . VAL A 1 366 ? -21.488 53.108 1.205   1.00 28.10 ? 332 VAL A HG11 1 
ATOM   5197 H HG12 . VAL A 1 366 ? -21.062 54.611 1.493   1.00 28.10 ? 332 VAL A HG12 1 
ATOM   5198 H HG13 . VAL A 1 366 ? -22.339 53.995 2.211   1.00 28.10 ? 332 VAL A HG13 1 
ATOM   5199 H HG21 . VAL A 1 366 ? -23.330 52.578 -0.228  1.00 32.56 ? 332 VAL A HG21 1 
ATOM   5200 H HG22 . VAL A 1 366 ? -24.372 53.376 0.666   1.00 32.56 ? 332 VAL A HG22 1 
ATOM   5201 H HG23 . VAL A 1 366 ? -24.230 53.712 -0.880  1.00 32.56 ? 332 VAL A HG23 1 
ATOM   5202 N N    . HIS A 1 367 ? -22.241 57.507 1.938   1.00 17.29 ? 333 HIS A N    1 
ATOM   5203 C CA   . HIS A 1 367 ? -21.211 58.468 2.325   1.00 17.78 ? 333 HIS A CA   1 
ATOM   5204 C C    . HIS A 1 367 ? -20.548 57.904 3.574   1.00 19.16 ? 333 HIS A C    1 
ATOM   5205 O O    . HIS A 1 367 ? -20.907 58.247 4.702   1.00 19.47 ? 333 HIS A O    1 
ATOM   5206 C CB   . HIS A 1 367 ? -21.802 59.854 2.557   1.00 20.43 ? 333 HIS A CB   1 
ATOM   5207 C CG   . HIS A 1 367 ? -22.433 60.447 1.336   1.00 23.60 ? 333 HIS A CG   1 
ATOM   5208 N ND1  . HIS A 1 367 ? -23.732 60.173 0.963   1.00 28.79 ? 333 HIS A ND1  1 
ATOM   5209 C CD2  . HIS A 1 367 ? -21.941 61.287 0.396   1.00 25.70 ? 333 HIS A CD2  1 
ATOM   5210 C CE1  . HIS A 1 367 ? -24.014 60.825 -0.150  1.00 27.88 ? 333 HIS A CE1  1 
ATOM   5211 N NE2  . HIS A 1 367 ? -22.945 61.508 -0.516  1.00 21.28 ? 333 HIS A NE2  1 
ATOM   5212 H H    . HIS A 1 367 ? -22.828 57.377 2.553   1.00 20.78 ? 333 HIS A H    1 
ATOM   5213 H HA   . HIS A 1 367 ? -20.553 58.554 1.618   1.00 21.36 ? 333 HIS A HA   1 
ATOM   5214 H HB2  . HIS A 1 367 ? -22.484 59.793 3.244   1.00 24.54 ? 333 HIS A HB2  1 
ATOM   5215 H HB3  . HIS A 1 367 ? -21.094 60.452 2.845   1.00 24.54 ? 333 HIS A HB3  1 
ATOM   5216 H HD1  . HIS A 1 367 ? -24.273 59.658 1.389   1.00 34.58 ? 333 HIS A HD1  1 
ATOM   5217 H HD2  . HIS A 1 367 ? -21.084 61.648 0.371   1.00 30.87 ? 333 HIS A HD2  1 
ATOM   5218 H HE1  . HIS A 1 367 ? -24.828 60.806 -0.600  1.00 33.48 ? 333 HIS A HE1  1 
ATOM   5219 N N    . ASN A 1 368 ? -19.579 57.018 3.360   1.00 17.78 ? 334 ASN A N    1 
ATOM   5220 C CA   . ASN A 1 368 ? -18.916 56.279 4.435   1.00 15.90 ? 334 ASN A CA   1 
ATOM   5221 C C    . ASN A 1 368 ? -19.995 55.500 5.179   1.00 19.75 ? 334 ASN A C    1 
ATOM   5222 O O    . ASN A 1 368 ? -20.686 54.688 4.540   1.00 17.88 ? 334 ASN A O    1 
ATOM   5223 C CB   . ASN A 1 368 ? -18.086 57.261 5.259   1.00 18.54 ? 334 ASN A CB   1 
ATOM   5224 C CG   . ASN A 1 368 ? -16.801 57.657 4.553   1.00 25.64 ? 334 ASN A CG   1 
ATOM   5225 O OD1  . ASN A 1 368 ? -16.092 56.806 4.013   1.00 23.56 ? 334 ASN A OD1  1 
ATOM   5226 N ND2  . ASN A 1 368 ? -16.507 58.953 4.534   1.00 21.29 ? 334 ASN A ND2  1 
ATOM   5227 H H    . ASN A 1 368 ? -19.278 56.821 2.578   1.00 21.37 ? 334 ASN A H    1 
ATOM   5228 H HA   . ASN A 1 368 ? -18.308 55.625 4.056   1.00 19.11 ? 334 ASN A HA   1 
ATOM   5229 H HB2  . ASN A 1 368 ? -18.606 58.065 5.415   1.00 22.27 ? 334 ASN A HB2  1 
ATOM   5230 H HB3  . ASN A 1 368 ? -17.851 56.848 6.105   1.00 22.27 ? 334 ASN A HB3  1 
ATOM   5231 H HD21 . ASN A 1 368 ? -17.033 59.519 4.909   1.00 25.58 ? 334 ASN A HD21 1 
ATOM   5232 H HD22 . ASN A 1 368 ? -15.789 59.225 4.145   1.00 25.58 ? 334 ASN A HD22 1 
ATOM   5233 N N    . TRP A 1 369 ? -20.191 55.700 6.479   1.00 19.64 ? 335 TRP A N    1 
ATOM   5234 C CA   . TRP A 1 369 ? -21.160 54.910 7.228   1.00 15.61 ? 335 TRP A CA   1 
ATOM   5235 C C    . TRP A 1 369 ? -22.563 55.501 7.204   1.00 18.45 ? 335 TRP A C    1 
ATOM   5236 O O    . TRP A 1 369 ? -23.461 54.950 7.850   1.00 23.41 ? 335 TRP A O    1 
ATOM   5237 C CB   . TRP A 1 369 ? -20.691 54.743 8.676   1.00 20.15 ? 335 TRP A CB   1 
ATOM   5238 C CG   . TRP A 1 369 ? -19.427 53.950 8.775   1.00 20.87 ? 335 TRP A CG   1 
ATOM   5239 C CD1  . TRP A 1 369 ? -18.225 54.379 9.252   1.00 22.83 ? 335 TRP A CD1  1 
ATOM   5240 C CD2  . TRP A 1 369 ? -19.236 52.588 8.370   1.00 16.16 ? 335 TRP A CD2  1 
ATOM   5241 N NE1  . TRP A 1 369 ? -17.297 53.369 9.175   1.00 20.32 ? 335 TRP A NE1  1 
ATOM   5242 C CE2  . TRP A 1 369 ? -17.893 52.259 8.637   1.00 18.60 ? 335 TRP A CE2  1 
ATOM   5243 C CE3  . TRP A 1 369 ? -20.072 51.615 7.810   1.00 19.08 ? 335 TRP A CE3  1 
ATOM   5244 C CZ2  . TRP A 1 369 ? -17.365 50.998 8.364   1.00 21.09 ? 335 TRP A CZ2  1 
ATOM   5245 C CZ3  . TRP A 1 369 ? -19.544 50.362 7.541   1.00 21.15 ? 335 TRP A CZ3  1 
ATOM   5246 C CH2  . TRP A 1 369 ? -18.204 50.066 7.819   1.00 19.83 ? 335 TRP A CH2  1 
ATOM   5247 H H    . TRP A 1 369 ? -19.773 56.287 6.949   1.00 23.59 ? 335 TRP A H    1 
ATOM   5248 H HA   . TRP A 1 369 ? -21.212 54.028 6.829   1.00 18.76 ? 335 TRP A HA   1 
ATOM   5249 H HB2  . TRP A 1 369 ? -20.529 55.619 9.060   1.00 24.20 ? 335 TRP A HB2  1 
ATOM   5250 H HB3  . TRP A 1 369 ? -21.378 54.281 9.181   1.00 24.20 ? 335 TRP A HB3  1 
ATOM   5251 H HD1  . TRP A 1 369 ? -18.057 55.232 9.583   1.00 27.42 ? 335 TRP A HD1  1 
ATOM   5252 H HE1  . TRP A 1 369 ? -16.476 53.424 9.424   1.00 24.41 ? 335 TRP A HE1  1 
ATOM   5253 H HE3  . TRP A 1 369 ? -20.962 51.805 7.623   1.00 22.93 ? 335 TRP A HE3  1 
ATOM   5254 H HZ2  . TRP A 1 369 ? -16.475 50.798 8.546   1.00 25.34 ? 335 TRP A HZ2  1 
ATOM   5255 H HZ3  . TRP A 1 369 ? -20.090 49.707 7.170   1.00 25.41 ? 335 TRP A HZ3  1 
ATOM   5256 H HH2  . TRP A 1 369 ? -17.878 49.216 7.628   1.00 23.82 ? 335 TRP A HH2  1 
ATOM   5257 N N    . GLU A 1 370 ? -22.781 56.587 6.470   1.00 17.80 ? 336 GLU A N    1 
ATOM   5258 C CA   . GLU A 1 370 ? -24.096 57.201 6.353   1.00 22.60 ? 336 GLU A CA   1 
ATOM   5259 C C    . GLU A 1 370 ? -24.764 56.737 5.065   1.00 19.64 ? 336 GLU A C    1 
ATOM   5260 O O    . GLU A 1 370 ? -24.155 56.784 3.991   1.00 18.99 ? 336 GLU A O    1 
ATOM   5261 C CB   . GLU A 1 370 ? -23.991 58.727 6.379   1.00 18.14 ? 336 GLU A CB   1 
ATOM   5262 C CG   . GLU A 1 370 ? -23.699 59.288 7.760   1.00 27.68 ? 336 GLU A CG   1 
ATOM   5263 C CD   . GLU A 1 370 ? -23.732 60.804 7.798   1.00 24.53 ? 336 GLU A CD   1 
ATOM   5264 O OE1  . GLU A 1 370 ? -24.414 61.410 6.945   1.00 29.41 ? 336 GLU A OE1  1 
ATOM   5265 O OE2  . GLU A 1 370 ? -23.073 61.387 8.683   1.00 30.04 ? 336 GLU A OE2  1 
ATOM   5266 H H    . GLU A 1 370 ? -22.170 56.994 6.022   1.00 21.39 ? 336 GLU A H    1 
ATOM   5267 H HA   . GLU A 1 370 ? -24.650 56.924 7.100   1.00 27.15 ? 336 GLU A HA   1 
ATOM   5268 H HB2  . GLU A 1 370 ? -23.273 59.001 5.788   1.00 21.79 ? 336 GLU A HB2  1 
ATOM   5269 H HB3  . GLU A 1 370 ? -24.832 59.103 6.076   1.00 21.79 ? 336 GLU A HB3  1 
ATOM   5270 H HG2  . GLU A 1 370 ? -24.365 58.959 8.383   1.00 33.25 ? 336 GLU A HG2  1 
ATOM   5271 H HG3  . GLU A 1 370 ? -22.815 59.001 8.038   1.00 33.25 ? 336 GLU A HG3  1 
ATOM   5272 N N    . LEU A 1 371 ? -26.010 56.283 5.184   1.00 17.37 ? 337 LEU A N    1 
ATOM   5273 C CA   . LEU A 1 371 ? -26.812 55.824 4.059   1.00 16.08 ? 337 LEU A CA   1 
ATOM   5274 C C    . LEU A 1 371 ? -28.034 56.720 3.919   1.00 17.03 ? 337 LEU A C    1 
ATOM   5275 O O    . LEU A 1 371 ? -28.646 57.107 4.920   1.00 20.84 ? 337 LEU A O    1 
ATOM   5276 C CB   . LEU A 1 371 ? -27.257 54.369 4.254   1.00 19.19 ? 337 LEU A CB   1 
ATOM   5277 C CG   . LEU A 1 371 ? -26.147 53.329 4.402   1.00 19.63 ? 337 LEU A CG   1 
ATOM   5278 C CD1  . LEU A 1 371 ? -26.728 51.922 4.484   1.00 18.56 ? 337 LEU A CD1  1 
ATOM   5279 C CD2  . LEU A 1 371 ? -25.175 53.437 3.246   1.00 20.81 ? 337 LEU A CD2  1 
ATOM   5280 H H    . LEU A 1 371 ? -26.425 56.231 5.935   1.00 20.87 ? 337 LEU A H    1 
ATOM   5281 H HA   . LEU A 1 371 ? -26.292 55.875 3.242   1.00 19.32 ? 337 LEU A HA   1 
ATOM   5282 H HB2  . LEU A 1 371 ? -27.797 54.325 5.059   1.00 23.05 ? 337 LEU A HB2  1 
ATOM   5283 H HB3  . LEU A 1 371 ? -27.788 54.112 3.484   1.00 23.05 ? 337 LEU A HB3  1 
ATOM   5284 H HG   . LEU A 1 371 ? -25.663 53.496 5.226   1.00 23.58 ? 337 LEU A HG   1 
ATOM   5285 H HD11 . LEU A 1 371 ? -26.002 51.285 4.577   1.00 22.30 ? 337 LEU A HD11 1 
ATOM   5286 H HD12 . LEU A 1 371 ? -27.316 51.868 5.254   1.00 22.30 ? 337 LEU A HD12 1 
ATOM   5287 H HD13 . LEU A 1 371 ? -27.227 51.739 3.673   1.00 22.30 ? 337 LEU A HD13 1 
ATOM   5288 H HD21 . LEU A 1 371 ? -24.668 52.613 3.181   1.00 25.00 ? 337 LEU A HD21 1 
ATOM   5289 H HD22 . LEU A 1 371 ? -25.674 53.584 2.427   1.00 25.00 ? 337 LEU A HD22 1 
ATOM   5290 H HD23 . LEU A 1 371 ? -24.576 54.182 3.406   1.00 25.00 ? 337 LEU A HD23 1 
ATOM   5291 N N    . THR A 1 372 ? -28.390 57.047 2.679   1.00 16.61 ? 338 THR A N    1 
ATOM   5292 C CA   . THR A 1 372 ? -29.539 57.900 2.417   1.00 16.83 ? 338 THR A CA   1 
ATOM   5293 C C    . THR A 1 372 ? -30.319 57.366 1.226   1.00 20.26 ? 338 THR A C    1 
ATOM   5294 O O    . THR A 1 372 ? -29.763 56.725 0.330   1.00 19.09 ? 338 THR A O    1 
ATOM   5295 C CB   . THR A 1 372 ? -29.123 59.356 2.150   1.00 18.52 ? 338 THR A CB   1 
ATOM   5296 O OG1  . THR A 1 372 ? -28.053 59.385 1.200   1.00 23.75 ? 338 THR A OG1  1 
ATOM   5297 C CG2  . THR A 1 372 ? -28.676 60.031 3.439   1.00 21.71 ? 338 THR A CG2  1 
ATOM   5298 H H    . THR A 1 372 ? -27.978 56.785 1.972   1.00 19.96 ? 338 THR A H    1 
ATOM   5299 H HA   . THR A 1 372 ? -30.123 57.885 3.191   1.00 20.22 ? 338 THR A HA   1 
ATOM   5300 H HB   . THR A 1 372 ? -29.881 59.847 1.797   1.00 22.25 ? 338 THR A HB   1 
ATOM   5301 H HG1  . THR A 1 372 ? -28.339 59.171 0.439   1.00 28.53 ? 338 THR A HG1  1 
ATOM   5302 H HG21 . THR A 1 372 ? -28.391 60.940 3.256   1.00 26.08 ? 338 THR A HG21 1 
ATOM   5303 H HG22 . THR A 1 372 ? -29.410 60.053 4.074   1.00 26.08 ? 338 THR A HG22 1 
ATOM   5304 H HG23 . THR A 1 372 ? -27.936 59.542 3.831   1.00 26.08 ? 338 THR A HG23 1 
ATOM   5305 N N    . ARG A 1 373 ? -31.620 57.644 1.230   1.00 20.40 ? 339 ARG A N    1 
ATOM   5306 C CA   . ARG A 1 373 ? -32.512 57.248 0.151   1.00 20.03 ? 339 ARG A CA   1 
ATOM   5307 C C    . ARG A 1 373 ? -33.703 58.193 0.155   1.00 20.72 ? 339 ARG A C    1 
ATOM   5308 O O    . ARG A 1 373 ? -34.147 58.642 1.216   1.00 16.44 ? 339 ARG A O    1 
ATOM   5309 C CB   . ARG A 1 373 ? -32.973 55.794 0.307   1.00 17.43 ? 339 ARG A CB   1 
ATOM   5310 C CG   . ARG A 1 373 ? -33.698 55.237 -0.909  1.00 13.51 ? 339 ARG A CG   1 
ATOM   5311 C CD   . ARG A 1 373 ? -32.723 54.806 -1.993  1.00 18.56 ? 339 ARG A CD   1 
ATOM   5312 N NE   . ARG A 1 373 ? -33.362 54.001 -3.027  1.00 14.31 ? 339 ARG A NE   1 
ATOM   5313 C CZ   . ARG A 1 373 ? -33.868 52.789 -2.834  1.00 18.28 ? 339 ARG A CZ   1 
ATOM   5314 N NH1  . ARG A 1 373 ? -33.798 52.187 -1.656  1.00 18.35 ? 339 ARG A NH1  1 
ATOM   5315 N NH2  . ARG A 1 373 ? -34.455 52.164 -3.850  1.00 15.25 ? 339 ARG A NH2  1 
ATOM   5316 H H    . ARG A 1 373 ? -32.018 58.071 1.862   1.00 24.51 ? 339 ARG A H    1 
ATOM   5317 H HA   . ARG A 1 373 ? -32.056 57.324 -0.702  1.00 24.07 ? 339 ARG A HA   1 
ATOM   5318 H HB2  . ARG A 1 373 ? -32.195 55.237 0.466   1.00 20.95 ? 339 ARG A HB2  1 
ATOM   5319 H HB3  . ARG A 1 373 ? -33.580 55.740 1.062   1.00 20.95 ? 339 ARG A HB3  1 
ATOM   5320 H HG2  . ARG A 1 373 ? -34.221 54.464 -0.644  1.00 16.24 ? 339 ARG A HG2  1 
ATOM   5321 H HG3  . ARG A 1 373 ? -34.280 55.920 -1.276  1.00 16.24 ? 339 ARG A HG3  1 
ATOM   5322 H HD2  . ARG A 1 373 ? -32.348 55.595 -2.415  1.00 22.30 ? 339 ARG A HD2  1 
ATOM   5323 H HD3  . ARG A 1 373 ? -32.016 54.276 -1.592  1.00 22.30 ? 339 ARG A HD3  1 
ATOM   5324 H HE   . ARG A 1 373 ? -33.416 54.335 -3.817  1.00 17.20 ? 339 ARG A HE   1 
ATOM   5325 H HH11 . ARG A 1 373 ? -33.417 52.582 -0.994  1.00 22.04 ? 339 ARG A HH11 1 
ATOM   5326 H HH12 . ARG A 1 373 ? -34.132 51.401 -1.555  1.00 22.04 ? 339 ARG A HH12 1 
ATOM   5327 H HH21 . ARG A 1 373 ? -34.504 52.545 -4.619  1.00 18.33 ? 339 ARG A HH21 1 
ATOM   5328 H HH22 . ARG A 1 373 ? -34.787 51.378 -3.737  1.00 18.33 ? 339 ARG A HH22 1 
ATOM   5329 N N    . ASN A 1 374 ? -34.212 58.493 -1.037  1.00 19.71 ? 340 ASN A N    1 
ATOM   5330 C CA   . ASN A 1 374 ? -35.323 59.420 -1.206  1.00 19.92 ? 340 ASN A CA   1 
ATOM   5331 C C    . ASN A 1 374 ? -36.525 58.688 -1.783  1.00 19.68 ? 340 ASN A C    1 
ATOM   5332 O O    . ASN A 1 374 ? -36.398 57.958 -2.772  1.00 17.15 ? 340 ASN A O    1 
ATOM   5333 C CB   . ASN A 1 374 ? -34.934 60.587 -2.116  1.00 25.74 ? 340 ASN A CB   1 
ATOM   5334 C CG   . ASN A 1 374 ? -34.079 61.617 -1.406  1.00 27.18 ? 340 ASN A CG   1 
ATOM   5335 O OD1  . ASN A 1 374 ? -34.204 61.819 -0.199  1.00 30.07 ? 340 ASN A OD1  1 
ATOM   5336 N ND2  . ASN A 1 374 ? -33.207 62.279 -2.156  1.00 32.93 ? 340 ASN A ND2  1 
ATOM   5337 H H    . ASN A 1 374 ? -33.922 58.164 -1.777  1.00 23.68 ? 340 ASN A H    1 
ATOM   5338 H HA   . ASN A 1 374 ? -35.575 59.773 -0.338  1.00 23.93 ? 340 ASN A HA   1 
ATOM   5339 H HB2  . ASN A 1 374 ? -34.428 60.245 -2.870  1.00 30.91 ? 340 ASN A HB2  1 
ATOM   5340 H HB3  . ASN A 1 374 ? -35.739 61.027 -2.429  1.00 30.91 ? 340 ASN A HB3  1 
ATOM   5341 H HD21 . ASN A 1 374 ? -32.699 62.874 -1.800  1.00 39.55 ? 340 ASN A HD21 1 
ATOM   5342 H HD22 . ASN A 1 374 ? -33.150 62.112 -2.998  1.00 39.55 ? 340 ASN A HD22 1 
ATOM   5343 N N    . TYR A 1 375 ? -37.683 58.886 -1.161  1.00 19.10 ? 341 TYR A N    1 
ATOM   5344 C CA   . TYR A 1 375 ? -38.953 58.376 -1.649  1.00 19.94 ? 341 TYR A CA   1 
ATOM   5345 C C    . TYR A 1 375 ? -39.892 59.549 -1.905  1.00 16.67 ? 341 TYR A C    1 
ATOM   5346 O O    . TYR A 1 375 ? -39.690 60.653 -1.394  1.00 18.29 ? 341 TYR A O    1 
ATOM   5347 C CB   . TYR A 1 375 ? -39.584 57.398 -0.648  1.00 18.79 ? 341 TYR A CB   1 
ATOM   5348 C CG   . TYR A 1 375 ? -38.835 56.089 -0.503  1.00 16.42 ? 341 TYR A CG   1 
ATOM   5349 C CD1  . TYR A 1 375 ? -37.710 55.991 0.307   1.00 16.71 ? 341 TYR A CD1  1 
ATOM   5350 C CD2  . TYR A 1 375 ? -39.258 54.950 -1.174  1.00 15.20 ? 341 TYR A CD2  1 
ATOM   5351 C CE1  . TYR A 1 375 ? -37.027 54.792 0.442   1.00 17.26 ? 341 TYR A CE1  1 
ATOM   5352 C CE2  . TYR A 1 375 ? -38.584 53.750 -1.047  1.00 19.99 ? 341 TYR A CE2  1 
ATOM   5353 C CZ   . TYR A 1 375 ? -37.470 53.675 -0.238  1.00 16.17 ? 341 TYR A CZ   1 
ATOM   5354 O OH   . TYR A 1 375 ? -36.801 52.477 -0.115  1.00 18.82 ? 341 TYR A OH   1 
ATOM   5355 H H    . TYR A 1 375 ? -37.758 59.330 -0.428  1.00 22.94 ? 341 TYR A H    1 
ATOM   5356 H HA   . TYR A 1 375 ? -38.821 57.897 -2.482  1.00 23.95 ? 341 TYR A HA   1 
ATOM   5357 H HB2  . TYR A 1 375 ? -39.609 57.820 0.225   1.00 22.57 ? 341 TYR A HB2  1 
ATOM   5358 H HB3  . TYR A 1 375 ? -40.485 57.190 -0.942  1.00 22.57 ? 341 TYR A HB3  1 
ATOM   5359 H HD1  . TYR A 1 375 ? -37.411 56.742 0.766   1.00 20.07 ? 341 TYR A HD1  1 
ATOM   5360 H HD2  . TYR A 1 375 ? -40.009 54.995 -1.720  1.00 18.27 ? 341 TYR A HD2  1 
ATOM   5361 H HE1  . TYR A 1 375 ? -36.276 54.741 0.988   1.00 20.73 ? 341 TYR A HE1  1 
ATOM   5362 H HE2  . TYR A 1 375 ? -38.880 52.997 -1.505  1.00 24.01 ? 341 TYR A HE2  1 
ATOM   5363 H HH   . TYR A 1 375 ? -36.099 52.585 0.335   1.00 22.61 ? 341 TYR A HH   1 
ATOM   5364 N N    . GLU A 1 376 ? -40.928 59.298 -2.712  1.00 19.67 ? 342 GLU A N    1 
ATOM   5365 C CA   . GLU A 1 376 ? -41.864 60.363 -3.064  1.00 23.93 ? 342 GLU A CA   1 
ATOM   5366 C C    . GLU A 1 376 ? -42.317 61.139 -1.834  1.00 18.69 ? 342 GLU A C    1 
ATOM   5367 O O    . GLU A 1 376 ? -42.416 62.370 -1.868  1.00 23.13 ? 342 GLU A O    1 
ATOM   5368 C CB   . GLU A 1 376 ? -43.077 59.783 -3.794  1.00 20.86 ? 342 GLU A CB   1 
ATOM   5369 C CG   . GLU A 1 376 ? -42.803 59.354 -5.226  1.00 24.78 ? 342 GLU A CG   1 
ATOM   5370 C CD   . GLU A 1 376 ? -44.007 58.702 -5.880  1.00 27.65 ? 342 GLU A CD   1 
ATOM   5371 O OE1  . GLU A 1 376 ? -44.642 57.837 -5.241  1.00 23.38 ? 342 GLU A OE1  1 
ATOM   5372 O OE2  . GLU A 1 376 ? -44.320 59.056 -7.036  1.00 32.34 ? 342 GLU A OE2  1 
ATOM   5373 H H    . GLU A 1 376 ? -41.107 58.533 -3.061  1.00 23.63 ? 342 GLU A H    1 
ATOM   5374 H HA   . GLU A 1 376 ? -41.414 60.979 -3.664  1.00 28.74 ? 342 GLU A HA   1 
ATOM   5375 H HB2  . GLU A 1 376 ? -43.386 59.003 -3.308  1.00 25.06 ? 342 GLU A HB2  1 
ATOM   5376 H HB3  . GLU A 1 376 ? -43.775 60.457 -3.818  1.00 25.06 ? 342 GLU A HB3  1 
ATOM   5377 H HG2  . GLU A 1 376 ? -42.562 60.134 -5.750  1.00 29.77 ? 342 GLU A HG2  1 
ATOM   5378 H HG3  . GLU A 1 376 ? -42.074 58.714 -5.231  1.00 29.77 ? 342 GLU A HG3  1 
ATOM   5379 N N    . HIS A 1 377 ? -42.587 60.435 -0.732  1.00 18.85 ? 343 HIS A N    1 
ATOM   5380 C CA   . HIS A 1 377 ? -43.118 61.052 0.477   1.00 17.98 ? 343 HIS A CA   1 
ATOM   5381 C C    . HIS A 1 377 ? -42.239 60.801 1.697   1.00 22.87 ? 343 HIS A C    1 
ATOM   5382 O O    . HIS A 1 377 ? -42.720 60.900 2.830   1.00 18.50 ? 343 HIS A O    1 
ATOM   5383 C CB   . HIS A 1 377 ? -44.537 60.547 0.747   1.00 20.87 ? 343 HIS A CB   1 
ATOM   5384 C CG   . HIS A 1 377 ? -45.491 60.799 -0.377  1.00 25.51 ? 343 HIS A CG   1 
ATOM   5385 N ND1  . HIS A 1 377 ? -45.681 62.049 -0.925  1.00 29.15 ? 343 HIS A ND1  1 
ATOM   5386 C CD2  . HIS A 1 377 ? -46.306 59.961 -1.059  1.00 31.69 ? 343 HIS A CD2  1 
ATOM   5387 C CE1  . HIS A 1 377 ? -46.575 61.970 -1.894  1.00 30.30 ? 343 HIS A CE1  1 
ATOM   5388 N NE2  . HIS A 1 377 ? -46.970 60.714 -1.997  1.00 36.42 ? 343 HIS A NE2  1 
ATOM   5389 H H    . HIS A 1 377 ? -42.467 59.586 -0.663  1.00 22.65 ? 343 HIS A H    1 
ATOM   5390 H HA   . HIS A 1 377 ? -43.152 62.011 0.337   1.00 21.60 ? 343 HIS A HA   1 
ATOM   5391 H HB2  . HIS A 1 377 ? -44.503 59.589 0.898   1.00 25.07 ? 343 HIS A HB2  1 
ATOM   5392 H HB3  . HIS A 1 377 ? -44.883 60.994 1.535   1.00 25.07 ? 343 HIS A HB3  1 
ATOM   5393 H HD1  . HIS A 1 377 ? -45.280 62.767 -0.675  1.00 35.01 ? 343 HIS A HD1  1 
ATOM   5394 H HD2  . HIS A 1 377 ? -46.400 59.046 -0.920  1.00 38.05 ? 343 HIS A HD2  1 
ATOM   5395 H HE1  . HIS A 1 377 ? -46.875 62.680 -2.416  1.00 36.39 ? 343 HIS A HE1  1 
ATOM   5396 N N    . ALA A 1 378 ? -40.962 60.481 1.500   1.00 22.45 ? 344 ALA A N    1 
ATOM   5397 C CA   . ALA A 1 378 ? -40.084 60.252 2.638   1.00 20.81 ? 344 ALA A CA   1 
ATOM   5398 C C    . ALA A 1 378 ? -38.633 60.376 2.202   1.00 19.17 ? 344 ALA A C    1 
ATOM   5399 O O    . ALA A 1 378 ? -38.274 59.983 1.089   1.00 22.85 ? 344 ALA A O    1 
ATOM   5400 C CB   . ALA A 1 378 ? -40.329 58.873 3.262   1.00 20.39 ? 344 ALA A CB   1 
ATOM   5401 H H    . ALA A 1 378 ? -40.590 60.392 0.730   1.00 26.96 ? 344 ALA A H    1 
ATOM   5402 H HA   . ALA A 1 378 ? -40.254 60.934 3.307   1.00 25.00 ? 344 ALA A HA   1 
ATOM   5403 H HB1  . ALA A 1 378 ? -39.786 58.787 4.061   1.00 24.49 ? 344 ALA A HB1  1 
ATOM   5404 H HB2  . ALA A 1 378 ? -41.268 58.792 3.490   1.00 24.49 ? 344 ALA A HB2  1 
ATOM   5405 H HB3  . ALA A 1 378 ? -40.084 58.188 2.620   1.00 24.49 ? 344 ALA A HB3  1 
ATOM   5406 N N    . SER A 1 379 ? -37.812 60.934 3.086   1.00 20.58 ? 345 SER A N    1 
ATOM   5407 C CA   . SER A 1 379 ? -36.366 60.965 2.928   1.00 23.46 ? 345 SER A CA   1 
ATOM   5408 C C    . SER A 1 379 ? -35.754 60.194 4.087   1.00 20.95 ? 345 SER A C    1 
ATOM   5409 O O    . SER A 1 379 ? -36.119 60.418 5.246   1.00 20.11 ? 345 SER A O    1 
ATOM   5410 C CB   . SER A 1 379 ? -35.836 62.401 2.893   1.00 24.89 ? 345 SER A CB   1 
ATOM   5411 O OG   . SER A 1 379 ? -35.591 62.886 4.201   1.00 38.92 ? 345 SER A OG   1 
ATOM   5412 H H    . SER A 1 379 ? -38.081 61.313 3.810   1.00 24.72 ? 345 SER A H    1 
ATOM   5413 H HA   . SER A 1 379 ? -36.109 60.543 2.093   1.00 28.17 ? 345 SER A HA   1 
ATOM   5414 H HB2  . SER A 1 379 ? -35.007 62.419 2.390   1.00 29.90 ? 345 SER A HB2  1 
ATOM   5415 H HB3  . SER A 1 379 ? -36.496 62.969 2.465   1.00 29.90 ? 345 SER A HB3  1 
ATOM   5416 H HG   . SER A 1 379 ? -35.290 63.669 4.166   1.00 46.73 ? 345 SER A HG   1 
ATOM   5417 N N    . VAL A 1 380 ? -34.834 59.287 3.773   1.00 18.19 ? 346 VAL A N    1 
ATOM   5418 C CA   . VAL A 1 380 ? -34.271 58.358 4.745   1.00 20.07 ? 346 VAL A CA   1 
ATOM   5419 C C    . VAL A 1 380 ? -32.812 58.713 4.988   1.00 17.20 ? 346 VAL A C    1 
ATOM   5420 O O    . VAL A 1 380 ? -32.077 59.044 4.050   1.00 19.32 ? 346 VAL A O    1 
ATOM   5421 C CB   . VAL A 1 380 ? -34.408 56.901 4.259   1.00 18.52 ? 346 VAL A CB   1 
ATOM   5422 C CG1  . VAL A 1 380 ? -33.769 55.946 5.253   1.00 21.03 ? 346 VAL A CG1  1 
ATOM   5423 C CG2  . VAL A 1 380 ? -35.874 56.553 4.035   1.00 19.58 ? 346 VAL A CG2  1 
ATOM   5424 H H    . VAL A 1 380 ? -34.512 59.188 2.981   1.00 21.86 ? 346 VAL A H    1 
ATOM   5425 H HA   . VAL A 1 380 ? -34.745 58.451 5.586   1.00 24.12 ? 346 VAL A HA   1 
ATOM   5426 H HB   . VAL A 1 380 ? -33.943 56.805 3.413   1.00 22.25 ? 346 VAL A HB   1 
ATOM   5427 H HG11 . VAL A 1 380 ? -34.040 55.040 5.038   1.00 25.26 ? 346 VAL A HG11 1 
ATOM   5428 H HG12 . VAL A 1 380 ? -32.804 56.026 5.192   1.00 25.26 ? 346 VAL A HG12 1 
ATOM   5429 H HG13 . VAL A 1 380 ? -34.065 56.177 6.147   1.00 25.26 ? 346 VAL A HG13 1 
ATOM   5430 H HG21 . VAL A 1 380 ? -35.936 55.640 3.714   1.00 23.52 ? 346 VAL A HG21 1 
ATOM   5431 H HG22 . VAL A 1 380 ? -36.351 56.641 4.875   1.00 23.52 ? 346 VAL A HG22 1 
ATOM   5432 H HG23 . VAL A 1 380 ? -36.246 57.161 3.378   1.00 23.52 ? 346 VAL A HG23 1 
ATOM   5433 N N    . TRP A 1 381 ? -32.397 58.644 6.252   1.00 18.77 ? 347 TRP A N    1 
ATOM   5434 C CA   . TRP A 1 381 ? -31.008 58.856 6.631   1.00 19.34 ? 347 TRP A CA   1 
ATOM   5435 C C    . TRP A 1 381 ? -30.686 57.999 7.845   1.00 18.51 ? 347 TRP A C    1 
ATOM   5436 O O    . TRP A 1 381 ? -31.496 57.898 8.770   1.00 19.48 ? 347 TRP A O    1 
ATOM   5437 C CB   . TRP A 1 381 ? -30.722 60.326 6.956   1.00 20.90 ? 347 TRP A CB   1 
ATOM   5438 C CG   . TRP A 1 381 ? -29.337 60.550 7.492   1.00 20.79 ? 347 TRP A CG   1 
ATOM   5439 C CD1  . TRP A 1 381 ? -28.215 60.839 6.769   1.00 23.53 ? 347 TRP A CD1  1 
ATOM   5440 C CD2  . TRP A 1 381 ? -28.924 60.491 8.865   1.00 20.16 ? 347 TRP A CD2  1 
ATOM   5441 N NE1  . TRP A 1 381 ? -27.132 60.968 7.605   1.00 20.95 ? 347 TRP A NE1  1 
ATOM   5442 C CE2  . TRP A 1 381 ? -27.540 60.760 8.897   1.00 21.42 ? 347 TRP A CE2  1 
ATOM   5443 C CE3  . TRP A 1 381 ? -29.590 60.240 10.068  1.00 25.07 ? 347 TRP A CE3  1 
ATOM   5444 C CZ2  . TRP A 1 381 ? -26.812 60.784 10.083  1.00 22.77 ? 347 TRP A CZ2  1 
ATOM   5445 C CZ3  . TRP A 1 381 ? -28.863 60.265 11.247  1.00 21.75 ? 347 TRP A CZ3  1 
ATOM   5446 C CH2  . TRP A 1 381 ? -27.489 60.535 11.245  1.00 25.59 ? 347 TRP A CH2  1 
ATOM   5447 H H    . TRP A 1 381 ? -32.913 58.472 6.919   1.00 22.55 ? 347 TRP A H    1 
ATOM   5448 H HA   . TRP A 1 381 ? -30.437 58.586 5.894   1.00 23.23 ? 347 TRP A HA   1 
ATOM   5449 H HB2  . TRP A 1 381 ? -30.818 60.852 6.146   1.00 25.11 ? 347 TRP A HB2  1 
ATOM   5450 H HB3  . TRP A 1 381 ? -31.355 60.630 7.626   1.00 25.11 ? 347 TRP A HB3  1 
ATOM   5451 H HD1  . TRP A 1 381 ? -28.188 60.935 5.844   1.00 28.26 ? 347 TRP A HD1  1 
ATOM   5452 H HE1  . TRP A 1 381 ? -26.329 61.150 7.358   1.00 25.17 ? 347 TRP A HE1  1 
ATOM   5453 H HE3  . TRP A 1 381 ? -30.502 60.060 10.078  1.00 30.11 ? 347 TRP A HE3  1 
ATOM   5454 H HZ2  . TRP A 1 381 ? -25.899 60.963 10.085  1.00 27.35 ? 347 TRP A HZ2  1 
ATOM   5455 H HZ3  . TRP A 1 381 ? -29.295 60.101 12.054  1.00 26.12 ? 347 TRP A HZ3  1 
ATOM   5456 H HH2  . TRP A 1 381 ? -27.027 60.545 12.051  1.00 30.74 ? 347 TRP A HH2  1 
ATOM   5457 N N    . LEU A 1 382 ? -29.500 57.393 7.840   1.00 15.56 ? 348 LEU A N    1 
ATOM   5458 C CA   . LEU A 1 382 ? -29.021 56.658 9.002   1.00 20.35 ? 348 LEU A CA   1 
ATOM   5459 C C    . LEU A 1 382 ? -27.500 56.614 8.978   1.00 17.76 ? 348 LEU A C    1 
ATOM   5460 O O    . LEU A 1 382 ? -26.869 56.755 7.928   1.00 17.42 ? 348 LEU A O    1 
ATOM   5461 C CB   . LEU A 1 382 ? -29.597 55.237 9.058   1.00 17.63 ? 348 LEU A CB   1 
ATOM   5462 C CG   . LEU A 1 382 ? -29.108 54.218 8.025   1.00 20.78 ? 348 LEU A CG   1 
ATOM   5463 C CD1  . LEU A 1 382 ? -29.210 52.808 8.589   1.00 24.54 ? 348 LEU A CD1  1 
ATOM   5464 C CD2  . LEU A 1 382 ? -29.901 54.337 6.735   1.00 16.61 ? 348 LEU A CD2  1 
ATOM   5465 H H    . LEU A 1 382 ? -28.956 57.394 7.175   1.00 18.70 ? 348 LEU A H    1 
ATOM   5466 H HA   . LEU A 1 382 ? -29.297 57.131 9.803   1.00 24.45 ? 348 LEU A HA   1 
ATOM   5467 H HB2  . LEU A 1 382 ? -29.389 54.869 9.931   1.00 21.18 ? 348 LEU A HB2  1 
ATOM   5468 H HB3  . LEU A 1 382 ? -30.558 55.305 8.947   1.00 21.18 ? 348 LEU A HB3  1 
ATOM   5469 H HG   . LEU A 1 382 ? -28.177 54.397 7.818   1.00 24.96 ? 348 LEU A HG   1 
ATOM   5470 H HD11 . LEU A 1 382 ? -28.973 52.172 7.896   1.00 29.48 ? 348 LEU A HD11 1 
ATOM   5471 H HD12 . LEU A 1 382 ? -28.601 52.722 9.339   1.00 29.48 ? 348 LEU A HD12 1 
ATOM   5472 H HD13 . LEU A 1 382 ? -30.121 52.651 8.884   1.00 29.48 ? 348 LEU A HD13 1 
ATOM   5473 H HD21 . LEU A 1 382 ? -29.667 53.598 6.151   1.00 19.96 ? 348 LEU A HD21 1 
ATOM   5474 H HD22 . LEU A 1 382 ? -30.848 54.307 6.942   1.00 19.96 ? 348 LEU A HD22 1 
ATOM   5475 H HD23 . LEU A 1 382 ? -29.682 55.179 6.307   1.00 19.96 ? 348 LEU A HD23 1 
ATOM   5476 N N    . ASN A 1 383 ? -26.923 56.414 10.159  1.00 18.68 ? 349 ASN A N    1 
ATOM   5477 C CA   . ASN A 1 383 ? -25.480 56.287 10.336  1.00 20.46 ? 349 ASN A CA   1 
ATOM   5478 C C    . ASN A 1 383 ? -25.217 54.934 10.984  1.00 21.45 ? 349 ASN A C    1 
ATOM   5479 O O    . ASN A 1 383 ? -25.577 54.717 12.147  1.00 21.38 ? 349 ASN A O    1 
ATOM   5480 C CB   . ASN A 1 383 ? -24.926 57.430 11.186  1.00 20.74 ? 349 ASN A CB   1 
ATOM   5481 C CG   . ASN A 1 383 ? -23.413 57.389 11.311  1.00 25.31 ? 349 ASN A CG   1 
ATOM   5482 O OD1  . ASN A 1 383 ? -22.821 56.329 11.516  1.00 21.66 ? 349 ASN A OD1  1 
ATOM   5483 N ND2  . ASN A 1 383 ? -22.779 58.548 11.186  1.00 32.86 ? 349 ASN A ND2  1 
ATOM   5484 H H    . ASN A 1 383 ? -27.360 56.348 10.896  1.00 22.44 ? 349 ASN A H    1 
ATOM   5485 H HA   . ASN A 1 383 ? -25.034 56.314 9.475   1.00 24.57 ? 349 ASN A HA   1 
ATOM   5486 H HB2  . ASN A 1 383 ? -25.171 58.275 10.778  1.00 24.91 ? 349 ASN A HB2  1 
ATOM   5487 H HB3  . ASN A 1 383 ? -25.303 57.371 12.078  1.00 24.91 ? 349 ASN A HB3  1 
ATOM   5488 H HD21 . ASN A 1 383 ? -21.922 58.578 11.248  1.00 39.46 ? 349 ASN A HD21 1 
ATOM   5489 H HD22 . ASN A 1 383 ? -23.226 59.269 11.042  1.00 39.46 ? 349 ASN A HD22 1 
ATOM   5490 N N    . LEU A 1 384 ? -24.593 54.027 10.231  1.00 19.98 ? 350 LEU A N    1 
ATOM   5491 C CA   . LEU A 1 384 ? -24.378 52.674 10.731  1.00 21.76 ? 350 LEU A CA   1 
ATOM   5492 C C    . LEU A 1 384 ? -23.412 52.649 11.907  1.00 16.75 ? 350 LEU A C    1 
ATOM   5493 O O    . LEU A 1 384 ? -23.476 51.735 12.737  1.00 20.70 ? 350 LEU A O    1 
ATOM   5494 C CB   . LEU A 1 384 ? -23.856 51.779 9.607   1.00 18.88 ? 350 LEU A CB   1 
ATOM   5495 C CG   . LEU A 1 384 ? -24.812 51.542 8.436   1.00 18.45 ? 350 LEU A CG   1 
ATOM   5496 C CD1  . LEU A 1 384 ? -24.123 50.723 7.356   1.00 19.58 ? 350 LEU A CD1  1 
ATOM   5497 C CD2  . LEU A 1 384 ? -26.087 50.854 8.904   1.00 19.60 ? 350 LEU A CD2  1 
ATOM   5498 H H    . LEU A 1 384 ? -24.290 54.169 9.439   1.00 24.01 ? 350 LEU A H    1 
ATOM   5499 H HA   . LEU A 1 384 ? -25.228 52.319 11.035  1.00 26.13 ? 350 LEU A HA   1 
ATOM   5500 H HB2  . LEU A 1 384 ? -23.054 52.187 9.244   1.00 22.68 ? 350 LEU A HB2  1 
ATOM   5501 H HB3  . LEU A 1 384 ? -23.646 50.911 9.985   1.00 22.68 ? 350 LEU A HB3  1 
ATOM   5502 H HG   . LEU A 1 384 ? -25.064 52.398 8.056   1.00 22.17 ? 350 LEU A HG   1 
ATOM   5503 H HD11 . LEU A 1 384 ? -24.779 50.465 6.689   1.00 23.53 ? 350 LEU A HD11 1 
ATOM   5504 H HD12 . LEU A 1 384 ? -23.429 51.262 6.946   1.00 23.53 ? 350 LEU A HD12 1 
ATOM   5505 H HD13 . LEU A 1 384 ? -23.733 49.932 7.760   1.00 23.53 ? 350 LEU A HD13 1 
ATOM   5506 H HD21 . LEU A 1 384 ? -26.610 50.596 8.129   1.00 23.55 ? 350 LEU A HD21 1 
ATOM   5507 H HD22 . LEU A 1 384 ? -25.850 50.067 9.420   1.00 23.55 ? 350 LEU A HD22 1 
ATOM   5508 H HD23 . LEU A 1 384 ? -26.594 51.470 9.455   1.00 23.55 ? 350 LEU A HD23 1 
ATOM   5509 N N    . ALA A 1 385 ? -22.515 53.633 11.998  1.00 23.15 ? 351 ALA A N    1 
ATOM   5510 C CA   . ALA A 1 385 ? -21.518 53.631 13.062  1.00 22.19 ? 351 ALA A CA   1 
ATOM   5511 C C    . ALA A 1 385 ? -22.105 54.064 14.399  1.00 24.49 ? 351 ALA A C    1 
ATOM   5512 O O    . ALA A 1 385 ? -21.701 53.548 15.447  1.00 24.49 ? 351 ALA A O    1 
ATOM   5513 C CB   . ALA A 1 385 ? -20.347 54.540 12.686  1.00 26.13 ? 351 ALA A CB   1 
ATOM   5514 H H    . ALA A 1 385 ? -22.464 54.303 11.462  1.00 27.81 ? 351 ALA A H    1 
ATOM   5515 H HA   . ALA A 1 385 ? -21.183 52.726 13.164  1.00 26.66 ? 351 ALA A HA   1 
ATOM   5516 H HB1  . ALA A 1 385 ? -19.689 54.518 13.398  1.00 31.38 ? 351 ALA A HB1  1 
ATOM   5517 H HB2  . ALA A 1 385 ? -19.952 54.220 11.860  1.00 31.38 ? 351 ALA A HB2  1 
ATOM   5518 H HB3  . ALA A 1 385 ? -20.676 55.445 12.566  1.00 31.38 ? 351 ALA A HB3  1 
ATOM   5519 N N    . THR A 1 386 ? -23.052 55.002 14.386  1.00 23.19 ? 352 THR A N    1 
ATOM   5520 C CA   . THR A 1 386 ? -23.704 55.475 15.599  1.00 29.00 ? 352 THR A CA   1 
ATOM   5521 C C    . THR A 1 386 ? -25.066 54.834 15.832  1.00 26.70 ? 352 THR A C    1 
ATOM   5522 O O    . THR A 1 386 ? -25.641 55.013 16.910  1.00 26.60 ? 352 THR A O    1 
ATOM   5523 C CB   . THR A 1 386 ? -23.872 56.997 15.543  1.00 27.45 ? 352 THR A CB   1 
ATOM   5524 O OG1  . THR A 1 386 ? -24.742 57.342 14.458  1.00 28.19 ? 352 THR A OG1  1 
ATOM   5525 C CG2  . THR A 1 386 ? -22.524 57.677 15.342  1.00 31.21 ? 352 THR A CG2  1 
ATOM   5526 H H    . THR A 1 386 ? -23.338 55.385 13.671  1.00 27.85 ? 352 THR A H    1 
ATOM   5527 H HA   . THR A 1 386 ? -23.141 55.262 16.359  1.00 34.83 ? 352 THR A HA   1 
ATOM   5528 H HB   . THR A 1 386 ? -24.251 57.313 16.378  1.00 32.96 ? 352 THR A HB   1 
ATOM   5529 H HG1  . THR A 1 386 ? -24.524 58.087 14.140  1.00 33.86 ? 352 THR A HG1  1 
ATOM   5530 H HG21 . THR A 1 386 ? -22.617 58.636 15.451  1.00 37.48 ? 352 THR A HG21 1 
ATOM   5531 H HG22 . THR A 1 386 ? -21.886 57.346 15.992  1.00 37.48 ? 352 THR A HG22 1 
ATOM   5532 H HG23 . THR A 1 386 ? -22.190 57.493 14.450  1.00 37.48 ? 352 THR A HG23 1 
ATOM   5533 N N    . LYS A 1 387 ? -25.587 54.094 14.855  1.00 27.66 ? 353 LYS A N    1 
ATOM   5534 C CA   . LYS A 1 387 ? -26.903 53.464 14.927  1.00 25.52 ? 353 LYS A CA   1 
ATOM   5535 C C    . LYS A 1 387 ? -28.024 54.481 15.131  1.00 26.36 ? 353 LYS A C    1 
ATOM   5536 O O    . LYS A 1 387 ? -29.116 54.125 15.586  1.00 32.28 ? 353 LYS A O    1 
ATOM   5537 C CB   . LYS A 1 387 ? -26.947 52.392 16.024  1.00 24.13 ? 353 LYS A CB   1 
ATOM   5538 C CG   . LYS A 1 387 ? -26.494 51.016 15.545  1.00 28.50 ? 353 LYS A CG   1 
ATOM   5539 C CD   . LYS A 1 387 ? -26.227 50.069 16.706  1.00 25.70 ? 353 LYS A CD   1 
ATOM   5540 H H    . LYS A 1 387 ? -25.181 53.937 14.114  1.00 33.22 ? 353 LYS A H    1 
ATOM   5541 H HA   . LYS A 1 387 ? -27.071 53.026 14.078  1.00 30.65 ? 353 LYS A HA   1 
ATOM   5542 H HB2  . LYS A 1 387 ? -26.363 52.661 16.749  1.00 28.99 ? 353 LYS A HB2  1 
ATOM   5543 H HB3  . LYS A 1 387 ? -27.859 52.309 16.345  1.00 28.99 ? 353 LYS A HB3  1 
ATOM   5544 H HG2  . LYS A 1 387 ? -27.187 50.627 14.989  1.00 34.22 ? 353 LYS A HG2  1 
ATOM   5545 H HG3  . LYS A 1 387 ? -25.674 51.110 15.035  1.00 34.22 ? 353 LYS A HG3  1 
ATOM   5546 N N    . GLU A 1 388 ? -27.786 55.744 14.791  1.00 25.84 ? 354 GLU A N    1 
ATOM   5547 C CA   . GLU A 1 388 ? -28.822 56.765 14.809  1.00 22.32 ? 354 GLU A CA   1 
ATOM   5548 C C    . GLU A 1 388 ? -29.411 56.918 13.411  1.00 28.69 ? 354 GLU A C    1 
ATOM   5549 O O    . GLU A 1 388 ? -28.750 56.645 12.405  1.00 23.17 ? 354 GLU A O    1 
ATOM   5550 C CB   . GLU A 1 388 ? -28.273 58.103 15.310  1.00 31.76 ? 354 GLU A CB   1 
ATOM   5551 C CG   . GLU A 1 388 ? -27.375 58.840 14.332  1.00 35.94 ? 354 GLU A CG   1 
ATOM   5552 C CD   . GLU A 1 388 ? -26.305 59.657 15.034  1.00 46.95 ? 354 GLU A CD   1 
ATOM   5553 O OE1  . GLU A 1 388 ? -25.141 59.627 14.581  1.00 40.05 ? 354 GLU A OE1  1 
ATOM   5554 O OE2  . GLU A 1 388 ? -26.628 60.331 16.037  1.00 40.23 ? 354 GLU A OE2  1 
ATOM   5555 H H    . GLU A 1 388 ? -27.016 56.037 14.542  1.00 31.03 ? 354 GLU A H    1 
ATOM   5556 H HA   . GLU A 1 388 ? -29.533 56.503 15.414  1.00 26.81 ? 354 GLU A HA   1 
ATOM   5557 H HB2  . GLU A 1 388 ? -29.022 58.686 15.511  1.00 38.14 ? 354 GLU A HB2  1 
ATOM   5558 H HB3  . GLU A 1 388 ? -27.754 57.940 16.113  1.00 38.14 ? 354 GLU A HB3  1 
ATOM   5559 H HG2  . GLU A 1 388 ? -26.934 58.194 13.758  1.00 43.16 ? 354 GLU A HG2  1 
ATOM   5560 H HG3  . GLU A 1 388 ? -27.915 59.444 13.798  1.00 43.16 ? 354 GLU A HG3  1 
ATOM   5561 N N    . ALA A 1 389 ? -30.670 57.347 13.355  1.00 20.57 ? 355 ALA A N    1 
ATOM   5562 C CA   . ALA A 1 389 ? -31.402 57.332 12.097  1.00 23.91 ? 355 ALA A CA   1 
ATOM   5563 C C    . ALA A 1 389 ? -32.524 58.356 12.147  1.00 22.25 ? 355 ALA A C    1 
ATOM   5564 O O    . ALA A 1 389 ? -32.998 58.738 13.220  1.00 19.21 ? 355 ALA A O    1 
ATOM   5565 C CB   . ALA A 1 389 ? -31.963 55.936 11.801  1.00 17.56 ? 355 ALA A CB   1 
ATOM   5566 H H    . ALA A 1 389 ? -31.116 57.648 14.026  1.00 24.71 ? 355 ALA A H    1 
ATOM   5567 H HA   . ALA A 1 389 ? -30.802 57.588 11.380  1.00 28.72 ? 355 ALA A HA   1 
ATOM   5568 H HB1  . ALA A 1 389 ? -32.476 55.970 10.979  1.00 21.10 ? 355 ALA A HB1  1 
ATOM   5569 H HB2  . ALA A 1 389 ? -31.226 55.314 11.706  1.00 21.10 ? 355 ALA A HB2  1 
ATOM   5570 H HB3  . ALA A 1 389 ? -32.534 55.663 12.537  1.00 21.10 ? 355 ALA A HB3  1 
ATOM   5571 N N    . LYS A 1 390 ? -32.951 58.786 10.962  1.00 19.49 ? 356 LYS A N    1 
ATOM   5572 C CA   . LYS A 1 390 ? -33.988 59.806 10.843  1.00 28.31 ? 356 LYS A CA   1 
ATOM   5573 C C    . LYS A 1 390 ? -34.762 59.568 9.557   1.00 26.45 ? 356 LYS A C    1 
ATOM   5574 O O    . LYS A 1 390 ? -34.165 59.502 8.479   1.00 20.79 ? 356 LYS A O    1 
ATOM   5575 C CB   . LYS A 1 390 ? -33.367 61.210 10.857  1.00 30.71 ? 356 LYS A CB   1 
ATOM   5576 C CG   . LYS A 1 390 ? -34.303 62.400 11.148  1.00 38.89 ? 356 LYS A CG   1 
ATOM   5577 C CD   . LYS A 1 390 ? -35.379 62.154 12.211  1.00 46.07 ? 356 LYS A CD   1 
ATOM   5578 C CE   . LYS A 1 390 ? -36.611 63.021 11.972  1.00 46.84 ? 356 LYS A CE   1 
ATOM   5579 N NZ   . LYS A 1 390 ? -37.844 62.392 12.521  1.00 55.76 ? 356 LYS A NZ   1 
ATOM   5580 H H    . LYS A 1 390 ? -32.654 58.500 10.208  1.00 23.42 ? 356 LYS A H    1 
ATOM   5581 H HA   . LYS A 1 390 ? -34.608 59.732 11.586  1.00 34.00 ? 356 LYS A HA   1 
ATOM   5582 H HB2  . LYS A 1 390 ? -32.676 61.223 11.538  1.00 36.88 ? 356 LYS A HB2  1 
ATOM   5583 H HB3  . LYS A 1 390 ? -32.975 61.370 9.984   1.00 36.88 ? 356 LYS A HB3  1 
ATOM   5584 H HG2  . LYS A 1 390 ? -33.763 63.146 11.454  1.00 46.70 ? 356 LYS A HG2  1 
ATOM   5585 H HG3  . LYS A 1 390 ? -34.760 62.638 10.326  1.00 46.70 ? 356 LYS A HG3  1 
ATOM   5586 H HD2  . LYS A 1 390 ? -35.651 61.223 12.183  1.00 55.31 ? 356 LYS A HD2  1 
ATOM   5587 H HD3  . LYS A 1 390 ? -35.021 62.369 13.087  1.00 55.31 ? 356 LYS A HD3  1 
ATOM   5588 H HE2  . LYS A 1 390 ? -36.488 63.879 12.407  1.00 56.23 ? 356 LYS A HE2  1 
ATOM   5589 H HE3  . LYS A 1 390 ? -36.733 63.147 11.018  1.00 56.23 ? 356 LYS A HE3  1 
ATOM   5590 H HZ1  . LYS A 1 390 ? -38.547 62.916 12.368  1.00 66.94 ? 356 LYS A HZ1  1 
ATOM   5591 H HZ2  . LYS A 1 390 ? -37.983 61.603 12.132  1.00 66.94 ? 356 LYS A HZ2  1 
ATOM   5592 H HZ3  . LYS A 1 390 ? -37.759 62.271 13.398  1.00 66.94 ? 356 LYS A HZ3  1 
ATOM   5593 N N    . ILE A 1 391 ? -36.080 59.425 9.675   1.00 28.26 ? 357 ILE A N    1 
ATOM   5594 C CA   . ILE A 1 391 ? -36.977 59.339 8.528   1.00 21.89 ? 357 ILE A CA   1 
ATOM   5595 C C    . ILE A 1 391 ? -37.832 60.598 8.522   1.00 29.25 ? 357 ILE A C    1 
ATOM   5596 O O    . ILE A 1 391 ? -38.624 60.824 9.445   1.00 23.82 ? 357 ILE A O    1 
ATOM   5597 C CB   . ILE A 1 391 ? -37.859 58.082 8.575   1.00 23.67 ? 357 ILE A CB   1 
ATOM   5598 C CG1  . ILE A 1 391 ? -36.999 56.820 8.688   1.00 22.99 ? 357 ILE A CG1  1 
ATOM   5599 C CG2  . ILE A 1 391 ? -38.746 58.015 7.334   1.00 23.07 ? 357 ILE A CG2  1 
ATOM   5600 C CD1  . ILE A 1 391 ? -37.796 55.561 8.969   1.00 21.20 ? 357 ILE A CD1  1 
ATOM   5601 H H    . ILE A 1 391 ? -36.487 59.373 10.430  1.00 33.93 ? 357 ILE A H    1 
ATOM   5602 H HA   . ILE A 1 391 ? -36.452 59.308 7.713   1.00 26.29 ? 357 ILE A HA   1 
ATOM   5603 H HB   . ILE A 1 391 ? -38.423 58.134 9.362   1.00 28.43 ? 357 ILE A HB   1 
ATOM   5604 H HG12 . ILE A 1 391 ? -36.525 56.690 7.852   1.00 27.62 ? 357 ILE A HG12 1 
ATOM   5605 H HG13 . ILE A 1 391 ? -36.366 56.938 9.414   1.00 27.62 ? 357 ILE A HG13 1 
ATOM   5606 H HG21 . ILE A 1 391 ? -39.224 57.171 7.333   1.00 27.71 ? 357 ILE A HG21 1 
ATOM   5607 H HG22 . ILE A 1 391 ? -39.376 58.752 7.356   1.00 27.71 ? 357 ILE A HG22 1 
ATOM   5608 H HG23 . ILE A 1 391 ? -38.188 58.080 6.543   1.00 27.71 ? 357 ILE A HG23 1 
ATOM   5609 H HD11 . ILE A 1 391 ? -37.182 54.831 9.147   1.00 25.46 ? 357 ILE A HD11 1 
ATOM   5610 H HD12 . ILE A 1 391 ? -38.363 55.712 9.742   1.00 25.46 ? 357 ILE A HD12 1 
ATOM   5611 H HD13 . ILE A 1 391 ? -38.341 55.352 8.195   1.00 25.46 ? 357 ILE A HD13 1 
ATOM   5612 N N    . ASN A 1 392 ? -37.670 61.417 7.486   1.00 24.97 ? 358 ASN A N    1 
ATOM   5613 C CA   . ASN A 1 392 ? -38.447 62.643 7.318   1.00 29.96 ? 358 ASN A CA   1 
ATOM   5614 C C    . ASN A 1 392 ? -39.632 62.319 6.415   1.00 25.31 ? 358 ASN A C    1 
ATOM   5615 O O    . ASN A 1 392 ? -39.497 62.265 5.191   1.00 21.74 ? 358 ASN A O    1 
ATOM   5616 C CB   . ASN A 1 392 ? -37.591 63.761 6.733   1.00 28.71 ? 358 ASN A CB   1 
ATOM   5617 C CG   . ASN A 1 392 ? -36.344 64.028 7.549   1.00 41.58 ? 358 ASN A CG   1 
ATOM   5618 O OD1  . ASN A 1 392 ? -36.079 63.346 8.537   1.00 47.49 ? 358 ASN A OD1  1 
ATOM   5619 N ND2  . ASN A 1 392 ? -35.569 65.025 7.138   1.00 48.06 ? 358 ASN A ND2  1 
ATOM   5620 H H    . ASN A 1 392 ? -37.104 61.281 6.853   1.00 29.99 ? 358 ASN A H    1 
ATOM   5621 H HA   . ASN A 1 392 ? -38.778 62.934 8.182   1.00 35.97 ? 358 ASN A HA   1 
ATOM   5622 H HB2  . ASN A 1 392 ? -37.316 63.513 5.836   1.00 34.48 ? 358 ASN A HB2  1 
ATOM   5623 H HB3  . ASN A 1 392 ? -38.113 64.578 6.706   1.00 34.48 ? 358 ASN A HB3  1 
ATOM   5624 H HD21 . ASN A 1 392 ? -35.788 65.481 6.442   1.00 57.70 ? 358 ASN A HD21 1 
ATOM   5625 H HD22 . ASN A 1 392 ? -34.850 65.216 7.569   1.00 57.70 ? 358 ASN A HD22 1 
ATOM   5626 N N    . TRP A 1 393 ? -40.792 62.096 7.025   1.00 23.04 ? 359 TRP A N    1 
ATOM   5627 C CA   . TRP A 1 393 ? -42.008 61.832 6.270   1.00 24.70 ? 359 TRP A CA   1 
ATOM   5628 C C    . TRP A 1 393 ? -42.567 63.139 5.723   1.00 26.21 ? 359 TRP A C    1 
ATOM   5629 O O    . TRP A 1 393 ? -42.661 64.135 6.447   1.00 30.51 ? 359 TRP A O    1 
ATOM   5630 C CB   . TRP A 1 393 ? -43.044 61.141 7.155   1.00 22.56 ? 359 TRP A CB   1 
ATOM   5631 C CG   . TRP A 1 393 ? -42.572 59.845 7.744   1.00 26.17 ? 359 TRP A CG   1 
ATOM   5632 C CD1  . TRP A 1 393 ? -42.071 59.649 8.998   1.00 24.65 ? 359 TRP A CD1  1 
ATOM   5633 C CD2  . TRP A 1 393 ? -42.572 58.560 7.108   1.00 21.24 ? 359 TRP A CD2  1 
ATOM   5634 N NE1  . TRP A 1 393 ? -41.754 58.326 9.181   1.00 23.80 ? 359 TRP A NE1  1 
ATOM   5635 C CE2  . TRP A 1 393 ? -42.053 57.636 8.035   1.00 21.26 ? 359 TRP A CE2  1 
ATOM   5636 C CE3  . TRP A 1 393 ? -42.958 58.103 5.844   1.00 21.71 ? 359 TRP A CE3  1 
ATOM   5637 C CZ2  . TRP A 1 393 ? -41.908 56.282 7.739   1.00 20.59 ? 359 TRP A CZ2  1 
ATOM   5638 C CZ3  . TRP A 1 393 ? -42.813 56.759 5.551   1.00 20.21 ? 359 TRP A CZ3  1 
ATOM   5639 C CH2  . TRP A 1 393 ? -42.293 55.864 6.495   1.00 23.58 ? 359 TRP A CH2  1 
ATOM   5640 H H    . TRP A 1 393 ? -40.900 62.092 7.878   1.00 27.67 ? 359 TRP A H    1 
ATOM   5641 H HA   . TRP A 1 393 ? -41.807 61.244 5.525   1.00 29.67 ? 359 TRP A HA   1 
ATOM   5642 H HB2  . TRP A 1 393 ? -43.272 61.734 7.888   1.00 27.10 ? 359 TRP A HB2  1 
ATOM   5643 H HB3  . TRP A 1 393 ? -43.833 60.954 6.622   1.00 27.10 ? 359 TRP A HB3  1 
ATOM   5644 H HD1  . TRP A 1 393 ? -41.961 60.316 9.637   1.00 29.61 ? 359 TRP A HD1  1 
ATOM   5645 H HE1  . TRP A 1 393 ? -41.422 57.985 9.897   1.00 28.58 ? 359 TRP A HE1  1 
ATOM   5646 H HE3  . TRP A 1 393 ? -43.305 58.692 5.212   1.00 26.08 ? 359 TRP A HE3  1 
ATOM   5647 H HZ2  . TRP A 1 393 ? -41.563 55.686 8.364   1.00 24.73 ? 359 TRP A HZ2  1 
ATOM   5648 H HZ3  . TRP A 1 393 ? -43.066 56.443 4.713   1.00 24.28 ? 359 TRP A HZ3  1 
ATOM   5649 H HH2  . TRP A 1 393 ? -42.206 54.966 6.270   1.00 28.33 ? 359 TRP A HH2  1 
ATOM   5650 N N    . LYS A 1 394 ? -42.934 63.134 4.444   1.00 25.82 ? 360 LYS A N    1 
ATOM   5651 C CA   . LYS A 1 394 ? -43.476 64.322 3.792   1.00 30.99 ? 360 LYS A CA   1 
ATOM   5652 C C    . LYS A 1 394 ? -45.001 64.293 3.787   1.00 32.28 ? 360 LYS A C    1 
ATOM   5653 O O    . LYS A 1 394 ? -45.657 65.313 3.582   1.00 37.64 ? 360 LYS A O    1 
ATOM   5654 C CB   . LYS A 1 394 ? -42.955 64.433 2.358   1.00 31.26 ? 360 LYS A CB   1 
ATOM   5655 C CG   . LYS A 1 394 ? -41.468 64.721 2.253   1.00 30.03 ? 360 LYS A CG   1 
ATOM   5656 C CD   . LYS A 1 394 ? -41.023 64.808 0.801   1.00 31.17 ? 360 LYS A CD   1 
ATOM   5657 O OXT  . LYS A 1 394 ? -45.612 63.245 3.986   1.00 26.89 ? 360 LYS A OXT  1 
ATOM   5658 H H    . LYS A 1 394 ? -42.880 62.448 3.928   1.00 31.01 ? 360 LYS A H    1 
ATOM   5659 H HA   . LYS A 1 394 ? -43.186 65.109 4.280   1.00 37.22 ? 360 LYS A HA   1 
ATOM   5660 H HB2  . LYS A 1 394 ? -43.125 63.595 1.901   1.00 37.54 ? 360 LYS A HB2  1 
ATOM   5661 H HB3  . LYS A 1 394 ? -43.426 65.155 1.912   1.00 37.54 ? 360 LYS A HB3  1 
ATOM   5662 H HG2  . LYS A 1 394 ? -41.273 65.568 2.684   1.00 36.07 ? 360 LYS A HG2  1 
ATOM   5663 H HG3  . LYS A 1 394 ? -40.971 64.008 2.683   1.00 36.07 ? 360 LYS A HG3  1 
HETATM 5664 O O    . HOH B 2 .   ? -37.659 54.559 16.847  1.00 31.42 ? 401 HOH A O    1 
HETATM 5665 O O    . HOH B 2 .   ? -44.854 11.584 5.422   1.00 35.52 ? 402 HOH A O    1 
HETATM 5666 O O    . HOH B 2 .   ? -46.776 48.832 0.628   1.00 23.91 ? 403 HOH A O    1 
HETATM 5667 O O    . HOH B 2 .   ? -30.059 12.465 9.425   1.00 21.00 ? 404 HOH A O    1 
HETATM 5668 O O    . HOH B 2 .   ? -40.510 11.733 -6.376  1.00 37.84 ? 405 HOH A O    1 
HETATM 5669 O O    . HOH B 2 .   ? -56.061 32.901 -4.174  1.00 41.78 ? 406 HOH A O    1 
HETATM 5670 O O    . HOH B 2 .   ? -22.305 34.068 7.215   1.00 31.17 ? 407 HOH A O    1 
HETATM 5671 O O    . HOH B 2 .   ? -60.579 22.424 2.583   1.00 37.12 ? 408 HOH A O    1 
HETATM 5672 O O    . HOH B 2 .   ? -31.793 32.681 13.728  1.00 34.27 ? 409 HOH A O    1 
HETATM 5673 O O    . HOH B 2 .   ? -22.287 30.772 -0.025  1.00 30.03 ? 410 HOH A O    1 
HETATM 5674 O O    . HOH B 2 .   ? -50.951 14.974 12.296  1.00 32.17 ? 411 HOH A O    1 
HETATM 5675 O O    . HOH B 2 .   ? -11.099 22.406 3.764   1.00 36.80 ? 412 HOH A O    1 
HETATM 5676 O O    . HOH B 2 .   ? -32.888 50.889 -7.029  1.00 26.54 ? 413 HOH A O    1 
HETATM 5677 O O    . HOH B 2 .   ? -34.741 14.362 14.599  1.00 19.63 ? 414 HOH A O    1 
HETATM 5678 O O    . HOH B 2 .   ? -48.067 15.017 -3.679  1.00 31.89 ? 415 HOH A O    1 
HETATM 5679 O O    . HOH B 2 .   ? -24.862 10.711 17.367  1.00 33.17 ? 416 HOH A O    1 
HETATM 5680 O O    . HOH B 2 .   ? -30.380 16.771 -9.180  1.00 28.31 ? 417 HOH A O    1 
HETATM 5681 O O    . HOH B 2 .   ? -48.175 12.473 12.453  1.00 33.66 ? 418 HOH A O    1 
HETATM 5682 O O    . HOH B 2 .   ? -60.788 34.005 -1.639  1.00 43.11 ? 419 HOH A O    1 
HETATM 5683 O O    . HOH B 2 .   ? -46.060 10.469 8.565   1.00 30.38 ? 420 HOH A O    1 
HETATM 5684 O O    . HOH B 2 .   ? -47.965 65.333 4.482   1.00 34.79 ? 421 HOH A O    1 
HETATM 5685 O O    . HOH B 2 .   ? -16.188 22.779 -0.990  1.00 34.77 ? 422 HOH A O    1 
HETATM 5686 O O    . HOH B 2 .   ? -24.149 24.432 -2.211  1.00 25.19 ? 423 HOH A O    1 
HETATM 5687 O O    . HOH B 2 .   ? -28.538 20.628 -9.663  1.00 30.15 ? 424 HOH A O    1 
HETATM 5688 O O    . HOH B 2 .   ? -18.067 25.878 1.339   1.00 33.80 ? 425 HOH A O    1 
HETATM 5689 O O    . HOH B 2 .   ? -36.835 8.479  -1.632  1.00 19.91 ? 426 HOH A O    1 
HETATM 5690 O O    . HOH B 2 .   ? -26.684 32.075 0.122   1.00 30.77 ? 427 HOH A O    1 
HETATM 5691 O O    . HOH B 2 .   ? -23.680 17.574 14.648  1.00 23.41 ? 428 HOH A O    1 
HETATM 5692 O O    . HOH B 2 .   ? -52.108 31.852 -4.881  1.00 31.46 ? 429 HOH A O    1 
HETATM 5693 O O    . HOH B 2 .   ? -43.738 40.863 -4.313  1.00 16.31 ? 430 HOH A O    1 
HETATM 5694 O O    . HOH B 2 .   ? -26.974 52.481 -4.904  1.00 20.74 ? 431 HOH A O    1 
HETATM 5695 O O    . HOH B 2 .   ? -27.278 8.962  3.994   1.00 18.11 ? 432 HOH A O    1 
HETATM 5696 O O    . HOH B 2 .   ? -37.955 35.076 -9.059  1.00 18.49 ? 433 HOH A O    1 
HETATM 5697 O O    . HOH B 2 .   ? -39.877 32.306 19.983  1.00 21.51 ? 434 HOH A O    1 
HETATM 5698 O O    . HOH B 2 .   ? -60.975 37.789 9.465   1.00 36.94 ? 435 HOH A O    1 
HETATM 5699 O O    . HOH B 2 .   ? -22.283 36.316 -2.465  1.00 25.40 ? 436 HOH A O    1 
HETATM 5700 O O    . HOH B 2 .   ? -25.937 35.828 -6.830  1.00 33.40 ? 437 HOH A O    1 
HETATM 5701 O O    . HOH B 2 .   ? -20.669 60.554 8.433   1.00 32.37 ? 438 HOH A O    1 
HETATM 5702 O O    . HOH B 2 .   ? -17.203 50.058 15.458  1.00 42.02 ? 439 HOH A O    1 
HETATM 5703 O O    . HOH B 2 .   ? -49.066 47.099 5.036   1.00 23.92 ? 440 HOH A O    1 
HETATM 5704 O O    . HOH B 2 .   ? -20.810 10.586 6.389   1.00 27.36 ? 441 HOH A O    1 
HETATM 5705 O O    . HOH B 2 .   ? -36.750 30.098 11.733  1.00 29.03 ? 442 HOH A O    1 
HETATM 5706 O O    . HOH B 2 .   ? -50.033 16.491 -8.413  1.00 31.85 ? 443 HOH A O    1 
HETATM 5707 O O    . HOH B 2 .   ? -28.045 4.389  8.570   1.00 35.45 ? 444 HOH A O    1 
HETATM 5708 O O    . HOH B 2 .   ? -12.648 20.308 -1.693  1.00 34.25 ? 445 HOH A O    1 
HETATM 5709 O O    . HOH B 2 .   ? -30.871 11.850 20.458  1.00 29.18 ? 446 HOH A O    1 
HETATM 5710 O O    . HOH B 2 .   ? -46.093 43.078 12.960  1.00 29.18 ? 447 HOH A O    1 
HETATM 5711 O O    . HOH B 2 .   ? -47.330 49.030 5.476   1.00 17.95 ? 448 HOH A O    1 
HETATM 5712 O O    . HOH B 2 .   ? -43.152 43.741 16.302  1.00 18.74 ? 449 HOH A O    1 
HETATM 5713 O O    . HOH B 2 .   ? -45.439 20.564 -10.616 1.00 33.53 ? 450 HOH A O    1 
HETATM 5714 O O    . HOH B 2 .   ? -36.354 41.763 32.730  1.00 34.13 ? 451 HOH A O    1 
HETATM 5715 O O    . HOH B 2 .   ? -27.471 39.993 -2.941  1.00 17.45 ? 452 HOH A O    1 
HETATM 5716 O O    . HOH B 2 .   ? -15.663 39.951 5.847   1.00 41.26 ? 453 HOH A O    1 
HETATM 5717 O O    . HOH B 2 .   ? -47.005 58.722 -3.658  1.00 30.74 ? 454 HOH A O    1 
HETATM 5718 O O    . HOH B 2 .   ? -32.973 30.990 29.318  1.00 27.85 ? 455 HOH A O    1 
HETATM 5719 O O    . HOH B 2 .   ? -24.724 45.236 21.523  1.00 38.00 ? 456 HOH A O    1 
HETATM 5720 O O    . HOH B 2 .   ? -58.332 21.375 4.608   1.00 41.51 ? 457 HOH A O    1 
HETATM 5721 O O    . HOH B 2 .   ? -45.405 53.182 6.074   1.00 17.00 ? 458 HOH A O    1 
HETATM 5722 O O    . HOH B 2 .   ? -39.943 9.338  -9.675  1.00 40.43 ? 459 HOH A O    1 
HETATM 5723 O O    . HOH B 2 .   ? -26.630 39.202 8.603   1.00 16.22 ? 460 HOH A O    1 
HETATM 5724 O O    . HOH B 2 .   ? -30.871 36.850 -7.963  1.00 18.45 ? 461 HOH A O    1 
HETATM 5725 O O    . HOH B 2 .   ? -24.496 42.981 -9.930  1.00 37.19 ? 462 HOH A O    1 
HETATM 5726 O O    . HOH B 2 .   ? -22.486 40.683 16.074  1.00 18.90 ? 463 HOH A O    1 
HETATM 5727 O O    . HOH B 2 .   ? -19.882 41.078 7.462   1.00 25.75 ? 464 HOH A O    1 
HETATM 5728 O O    . HOH B 2 .   ? -49.239 50.624 -5.210  1.00 36.88 ? 465 HOH A O    1 
HETATM 5729 O O    . HOH B 2 .   ? -46.686 32.247 -6.735  1.00 20.24 ? 466 HOH A O    1 
HETATM 5730 O O    . HOH B 2 .   ? -43.144 53.103 16.486  1.00 26.42 ? 467 HOH A O    1 
HETATM 5731 O O    . HOH B 2 .   ? -36.439 43.183 -3.572  1.00 15.48 ? 468 HOH A O    1 
HETATM 5732 O O    . HOH B 2 .   ? -37.397 19.257 7.157   1.00 16.33 ? 469 HOH A O    1 
HETATM 5733 O O    . HOH B 2 .   ? -39.532 56.394 13.550  1.00 30.42 ? 470 HOH A O    1 
HETATM 5734 O O    . HOH B 2 .   ? -44.382 18.759 -11.036 1.00 32.34 ? 471 HOH A O    1 
HETATM 5735 O O    . HOH B 2 .   ? -55.352 23.192 15.391  1.00 31.22 ? 472 HOH A O    1 
HETATM 5736 O O    . HOH B 2 .   ? -52.739 34.079 -4.145  1.00 27.06 ? 473 HOH A O    1 
HETATM 5737 O O    . HOH B 2 .   ? -49.863 17.889 9.714   1.00 16.81 ? 474 HOH A O    1 
HETATM 5738 O O    . HOH B 2 .   ? -61.587 30.504 -1.402  1.00 47.53 ? 475 HOH A O    1 
HETATM 5739 O O    . HOH B 2 .   ? -53.220 50.228 9.609   1.00 37.86 ? 476 HOH A O    1 
HETATM 5740 O O    . HOH B 2 .   ? -39.565 14.132 -4.958  1.00 15.86 ? 477 HOH A O    1 
HETATM 5741 O O    . HOH B 2 .   ? -42.008 53.726 22.804  1.00 31.03 ? 478 HOH A O    1 
HETATM 5742 O O    . HOH B 2 .   ? -49.137 56.399 10.941  1.00 32.79 ? 479 HOH A O    1 
HETATM 5743 O O    . HOH B 2 .   ? -45.619 60.654 4.507   1.00 22.74 ? 480 HOH A O    1 
HETATM 5744 O O    . HOH B 2 .   ? -46.686 50.189 25.813  1.00 37.73 ? 481 HOH A O    1 
HETATM 5745 O O    . HOH B 2 .   ? -48.287 22.274 13.937  1.00 19.07 ? 482 HOH A O    1 
HETATM 5746 O O    . HOH B 2 .   ? -39.598 14.615 19.777  1.00 35.18 ? 483 HOH A O    1 
HETATM 5747 O O    . HOH B 2 .   ? -30.015 23.913 -12.616 1.00 31.70 ? 484 HOH A O    1 
HETATM 5748 O O    . HOH B 2 .   ? -26.333 22.803 12.278  1.00 19.88 ? 485 HOH A O    1 
HETATM 5749 O O    . HOH B 2 .   ? -38.397 15.344 8.811   1.00 17.63 ? 486 HOH A O    1 
HETATM 5750 O O    . HOH B 2 .   ? -27.160 13.956 -6.867  1.00 29.80 ? 487 HOH A O    1 
HETATM 5751 O O    . HOH B 2 .   ? -30.388 35.180 6.864   1.00 18.28 ? 488 HOH A O    1 
HETATM 5752 O O    . HOH B 2 .   ? -39.800 10.963 17.045  1.00 32.10 ? 489 HOH A O    1 
HETATM 5753 O O    . HOH B 2 .   ? -37.540 59.783 12.104  1.00 30.20 ? 490 HOH A O    1 
HETATM 5754 O O    . HOH B 2 .   ? -40.556 55.420 16.815  1.00 32.24 ? 491 HOH A O    1 
HETATM 5755 O O    . HOH B 2 .   ? -34.879 22.375 -11.791 1.00 24.31 ? 492 HOH A O    1 
HETATM 5756 O O    . HOH B 2 .   ? -18.230 11.186 6.764   1.00 32.35 ? 493 HOH A O    1 
HETATM 5757 O O    . HOH B 2 .   ? -34.933 14.737 -5.300  1.00 19.47 ? 494 HOH A O    1 
HETATM 5758 O O    . HOH B 2 .   ? -58.024 41.639 5.695   1.00 36.13 ? 495 HOH A O    1 
HETATM 5759 O O    . HOH B 2 .   ? -24.261 14.324 16.419  1.00 25.73 ? 496 HOH A O    1 
HETATM 5760 O O    . HOH B 2 .   ? -47.375 39.166 22.317  1.00 38.94 ? 497 HOH A O    1 
HETATM 5761 O O    . HOH B 2 .   ? -32.086 42.703 27.402  1.00 35.14 ? 498 HOH A O    1 
HETATM 5762 O O    . HOH B 2 .   ? -33.694 29.856 10.903  1.00 39.01 ? 499 HOH A O    1 
HETATM 5763 O O    . HOH B 2 .   ? -46.900 41.877 -1.124  1.00 22.83 ? 500 HOH A O    1 
HETATM 5764 O O    . HOH B 2 .   ? -38.286 32.889 24.957  1.00 26.52 ? 501 HOH A O    1 
HETATM 5765 O O    . HOH B 2 .   ? -50.023 23.354 2.013   1.00 15.60 ? 502 HOH A O    1 
HETATM 5766 O O    . HOH B 2 .   ? -37.727 17.831 16.972  1.00 22.25 ? 503 HOH A O    1 
HETATM 5767 O O    . HOH B 2 .   ? -31.407 38.714 21.364  1.00 25.81 ? 504 HOH A O    1 
HETATM 5768 O O    . HOH B 2 .   ? -29.832 24.717 -7.711  1.00 28.15 ? 505 HOH A O    1 
HETATM 5769 O O    . HOH B 2 .   ? -23.235 38.837 3.357   1.00 19.50 ? 506 HOH A O    1 
HETATM 5770 O O    . HOH B 2 .   ? -25.872 36.578 12.746  1.00 14.54 ? 507 HOH A O    1 
HETATM 5771 O O    . HOH B 2 .   ? -51.468 48.027 6.141   1.00 32.13 ? 508 HOH A O    1 
HETATM 5772 O O    . HOH B 2 .   ? -25.855 46.675 -3.524  1.00 18.96 ? 509 HOH A O    1 
HETATM 5773 O O    . HOH B 2 .   ? -26.733 43.363 10.005  1.00 16.84 ? 510 HOH A O    1 
HETATM 5774 O O    . HOH B 2 .   ? -27.531 46.318 16.596  1.00 22.45 ? 511 HOH A O    1 
HETATM 5775 O O    . HOH B 2 .   ? -46.037 25.624 -11.022 1.00 30.25 ? 512 HOH A O    1 
HETATM 5776 O O    . HOH B 2 .   ? -20.426 60.601 5.927   1.00 25.14 ? 513 HOH A O    1 
HETATM 5777 O O    . HOH B 2 .   ? -55.320 21.850 17.638  1.00 38.01 ? 514 HOH A O    1 
HETATM 5778 O O    . HOH B 2 .   ? -49.044 21.780 4.059   1.00 14.56 ? 515 HOH A O    1 
HETATM 5779 O O    . HOH B 2 .   ? -48.358 59.687 5.517   1.00 30.27 ? 516 HOH A O    1 
HETATM 5780 O O    . HOH B 2 .   ? -21.989 47.766 15.622  1.00 32.65 ? 517 HOH A O    1 
HETATM 5781 O O    . HOH B 2 .   ? -53.286 16.454 11.789  1.00 33.43 ? 518 HOH A O    1 
HETATM 5782 O O    . HOH B 2 .   ? -22.247 29.207 7.399   1.00 24.48 ? 519 HOH A O    1 
HETATM 5783 O O    . HOH B 2 .   ? -22.046 39.067 1.179   1.00 21.49 ? 520 HOH A O    1 
HETATM 5784 O O    . HOH B 2 .   ? -48.631 56.416 -0.311  1.00 24.20 ? 521 HOH A O    1 
HETATM 5785 O O    . HOH B 2 .   ? -41.862 6.656  12.837  1.00 36.56 ? 522 HOH A O    1 
HETATM 5786 O O    . HOH B 2 .   ? -33.384 48.495 16.765  1.00 18.80 ? 523 HOH A O    1 
HETATM 5787 O O    . HOH B 2 .   ? -17.789 27.323 12.267  1.00 43.78 ? 524 HOH A O    1 
HETATM 5788 O O    . HOH B 2 .   ? -15.771 12.853 3.894   1.00 22.21 ? 525 HOH A O    1 
HETATM 5789 O O    . HOH B 2 .   ? -37.907 16.790 -8.535  1.00 21.83 ? 526 HOH A O    1 
HETATM 5790 O O    . HOH B 2 .   ? -32.211 61.444 2.761   1.00 31.11 ? 527 HOH A O    1 
HETATM 5791 O O    . HOH B 2 .   ? -26.737 41.941 22.984  1.00 34.53 ? 528 HOH A O    1 
HETATM 5792 O O    . HOH B 2 .   ? -33.982 25.988 12.545  1.00 32.34 ? 529 HOH A O    1 
HETATM 5793 O O    . HOH B 2 .   ? -31.389 44.541 16.402  1.00 19.91 ? 530 HOH A O    1 
HETATM 5794 O O    . HOH B 2 .   ? -57.484 29.585 10.906  1.00 23.97 ? 531 HOH A O    1 
HETATM 5795 O O    . HOH B 2 .   ? -55.985 31.373 19.904  1.00 30.54 ? 532 HOH A O    1 
HETATM 5796 O O    . HOH B 2 .   ? -24.725 50.339 -3.942  1.00 29.01 ? 533 HOH A O    1 
HETATM 5797 O O    . HOH B 2 .   ? -27.850 43.144 -8.840  1.00 22.43 ? 534 HOH A O    1 
HETATM 5798 O O    . HOH B 2 .   ? -24.024 62.911 -2.610  1.00 23.27 ? 535 HOH A O    1 
HETATM 5799 O O    . HOH B 2 .   ? -20.799 34.072 -0.110  1.00 34.87 ? 536 HOH A O    1 
HETATM 5800 O O    . HOH B 2 .   ? -30.740 12.163 5.649   1.00 20.24 ? 537 HOH A O    1 
HETATM 5801 O O    . HOH B 2 .   ? -34.753 37.238 -10.931 1.00 24.43 ? 538 HOH A O    1 
HETATM 5802 O O    . HOH B 2 .   ? -22.045 40.307 -3.149  1.00 30.83 ? 539 HOH A O    1 
HETATM 5803 O O    . HOH B 2 .   ? -46.343 15.170 5.061   1.00 30.11 ? 540 HOH A O    1 
HETATM 5804 O O    . HOH B 2 .   ? -50.763 49.989 2.596   1.00 30.89 ? 541 HOH A O    1 
HETATM 5805 O O    . HOH B 2 .   ? -59.610 40.746 0.000   0.50 34.78 ? 542 HOH A O    1 
HETATM 5806 O O    . HOH B 2 .   ? -22.752 50.468 15.082  1.00 27.69 ? 543 HOH A O    1 
HETATM 5807 O O    . HOH B 2 .   ? -23.917 23.858 10.981  1.00 20.63 ? 544 HOH A O    1 
HETATM 5808 O O    . HOH B 2 .   ? -53.070 43.113 2.044   1.00 28.95 ? 545 HOH A O    1 
HETATM 5809 O O    . HOH B 2 .   ? -26.338 17.416 -10.344 1.00 36.47 ? 546 HOH A O    1 
HETATM 5810 O O    . HOH B 2 .   ? -17.222 15.054 -2.876  1.00 22.74 ? 547 HOH A O    1 
HETATM 5811 O O    . HOH B 2 .   ? -27.323 61.935 0.404   1.00 29.12 ? 548 HOH A O    1 
HETATM 5812 O O    . HOH B 2 .   ? -24.457 37.939 -3.162  1.00 23.68 ? 549 HOH A O    1 
HETATM 5813 O O    . HOH B 2 .   ? -45.348 24.124 -13.980 1.00 40.41 ? 550 HOH A O    1 
HETATM 5814 O O    . HOH B 2 .   ? -45.478 14.419 -3.007  1.00 20.41 ? 551 HOH A O    1 
HETATM 5815 O O    . HOH B 2 .   ? -34.630 52.986 -6.493  1.00 21.47 ? 552 HOH A O    1 
HETATM 5816 O O    . HOH B 2 .   ? -19.156 35.664 15.101  1.00 31.46 ? 553 HOH A O    1 
HETATM 5817 O O    . HOH B 2 .   ? -17.101 12.177 13.631  1.00 35.61 ? 554 HOH A O    1 
HETATM 5818 O O    . HOH B 2 .   ? -18.028 44.305 3.486   1.00 33.67 ? 555 HOH A O    1 
HETATM 5819 O O    . HOH B 2 .   ? -40.579 36.967 12.222  1.00 16.29 ? 556 HOH A O    1 
HETATM 5820 O O    . HOH B 2 .   ? -28.325 39.985 20.453  1.00 24.96 ? 557 HOH A O    1 
HETATM 5821 O O    . HOH B 2 .   ? -46.982 40.681 29.648  1.00 37.91 ? 558 HOH A O    1 
HETATM 5822 O O    . HOH B 2 .   ? -20.923 41.647 12.766  1.00 20.84 ? 559 HOH A O    1 
HETATM 5823 O O    . HOH B 2 .   ? -20.438 18.832 -8.056  1.00 43.46 ? 560 HOH A O    1 
HETATM 5824 O O    . HOH B 2 .   ? -35.187 35.624 -9.135  1.00 18.03 ? 561 HOH A O    1 
HETATM 5825 O O    . HOH B 2 .   ? -40.004 17.274 10.034  1.00 17.36 ? 562 HOH A O    1 
HETATM 5826 O O    . HOH B 2 .   ? -47.791 42.952 1.195   1.00 23.98 ? 563 HOH A O    1 
HETATM 5827 O O    . HOH B 2 .   ? -31.115 35.910 28.324  1.00 26.27 ? 564 HOH A O    1 
HETATM 5828 O O    . HOH B 2 .   ? -25.505 58.955 2.738   1.00 20.86 ? 565 HOH A O    1 
HETATM 5829 O O    . HOH B 2 .   ? -20.003 38.554 14.892  1.00 26.66 ? 566 HOH A O    1 
HETATM 5830 O O    . HOH B 2 .   ? -37.373 14.268 17.620  1.00 36.57 ? 567 HOH A O    1 
HETATM 5831 O O    . HOH B 2 .   ? -28.818 37.549 8.153   1.00 14.86 ? 568 HOH A O    1 
HETATM 5832 O O    . HOH B 2 .   ? -56.641 25.463 15.990  1.00 28.56 ? 569 HOH A O    1 
HETATM 5833 O O    . HOH B 2 .   ? -32.700 44.863 13.141  1.00 18.29 ? 570 HOH A O    1 
HETATM 5834 O O    . HOH B 2 .   ? -21.265 21.656 12.879  1.00 30.89 ? 571 HOH A O    1 
HETATM 5835 O O    . HOH B 2 .   ? -57.790 36.709 18.554  1.00 29.98 ? 572 HOH A O    1 
HETATM 5836 O O    . HOH B 2 .   ? -33.400 12.541 -5.773  1.00 24.78 ? 573 HOH A O    1 
HETATM 5837 O O    . HOH B 2 .   ? -36.682 45.051 -8.110  1.00 34.42 ? 574 HOH A O    1 
HETATM 5838 O O    . HOH B 2 .   ? -19.989 58.232 11.215  1.00 33.96 ? 575 HOH A O    1 
HETATM 5839 O O    . HOH B 2 .   ? -19.505 20.967 -3.717  1.00 25.02 ? 576 HOH A O    1 
HETATM 5840 O O    . HOH B 2 .   ? -54.699 29.396 -4.042  1.00 38.30 ? 577 HOH A O    1 
HETATM 5841 O O    . HOH B 2 .   ? -16.746 36.903 3.831   1.00 33.15 ? 578 HOH A O    1 
HETATM 5842 O O    . HOH B 2 .   ? -59.065 25.969 6.295   1.00 25.61 ? 579 HOH A O    1 
HETATM 5843 O O    . HOH B 2 .   ? -44.423 40.448 12.282  1.00 16.98 ? 580 HOH A O    1 
HETATM 5844 O O    . HOH B 2 .   ? -25.351 61.032 4.316   1.00 22.76 ? 581 HOH A O    1 
HETATM 5845 O O    . HOH B 2 .   ? -48.304 44.844 29.890  1.00 38.84 ? 582 HOH A O    1 
HETATM 5846 O O    . HOH B 2 .   ? -55.416 20.971 20.911  1.00 36.29 ? 583 HOH A O    1 
HETATM 5847 O O    . HOH B 2 .   ? -30.500 60.306 -1.098  1.00 28.98 ? 584 HOH A O    1 
HETATM 5848 O O    . HOH B 2 .   ? -58.686 29.612 0.145   1.00 32.81 ? 585 HOH A O    1 
HETATM 5849 O O    . HOH B 2 .   ? -47.209 16.656 -10.200 1.00 35.05 ? 586 HOH A O    1 
HETATM 5850 O O    . HOH B 2 .   ? -43.247 37.750 23.348  1.00 28.50 ? 587 HOH A O    1 
HETATM 5851 O O    . HOH B 2 .   ? -37.553 62.370 -0.662  1.00 28.83 ? 588 HOH A O    1 
HETATM 5852 O O    . HOH B 2 .   ? -42.362 29.634 16.095  1.00 30.21 ? 589 HOH A O    1 
HETATM 5853 O O    . HOH B 2 .   ? -46.928 45.628 2.684   1.00 24.47 ? 590 HOH A O    1 
HETATM 5854 O O    . HOH B 2 .   ? -43.774 43.820 -7.904  1.00 21.30 ? 591 HOH A O    1 
HETATM 5855 O O    . HOH B 2 .   ? -46.812 48.136 18.922  1.00 33.07 ? 592 HOH A O    1 
HETATM 5856 O O    . HOH B 2 .   ? -28.451 11.716 11.651  1.00 20.23 ? 593 HOH A O    1 
HETATM 5857 O O    . HOH B 2 .   ? -30.919 51.498 -4.587  1.00 16.70 ? 594 HOH A O    1 
HETATM 5858 O O    . HOH B 2 .   ? -43.789 44.199 11.933  1.00 30.20 ? 595 HOH A O    1 
HETATM 5859 O O    . HOH B 2 .   ? -47.015 40.875 20.739  1.00 33.36 ? 596 HOH A O    1 
HETATM 5860 O O    . HOH B 2 .   ? -51.408 18.641 0.858   1.00 30.63 ? 597 HOH A O    1 
HETATM 5861 O O    . HOH B 2 .   ? -31.075 28.410 -6.992  1.00 28.95 ? 598 HOH A O    1 
HETATM 5862 O O    . HOH B 2 .   ? -60.803 32.724 6.698   1.00 30.59 ? 599 HOH A O    1 
HETATM 5863 O O    . HOH B 2 .   ? -25.736 21.791 -9.771  1.00 44.39 ? 600 HOH A O    1 
HETATM 5864 O O    . HOH B 2 .   ? -37.211 42.571 -7.376  1.00 18.71 ? 601 HOH A O    1 
HETATM 5865 O O    . HOH B 2 .   ? -39.017 22.088 8.817   1.00 14.02 ? 602 HOH A O    1 
HETATM 5866 O O    . HOH B 2 .   ? -32.852 26.265 10.731  1.00 21.08 ? 603 HOH A O    1 
HETATM 5867 O O    . HOH B 2 .   ? -33.988 12.568 16.793  1.00 37.82 ? 604 HOH A O    1 
HETATM 5868 O O    . HOH B 2 .   ? -53.034 44.015 -2.526  1.00 31.62 ? 605 HOH A O    1 
HETATM 5869 O O    . HOH B 2 .   ? -62.681 31.290 5.704   1.00 38.98 ? 606 HOH A O    1 
HETATM 5870 O O    . HOH B 2 .   ? -53.722 37.436 19.258  1.00 35.56 ? 607 HOH A O    1 
HETATM 5871 O O    . HOH B 2 .   ? -14.663 53.638 10.335  1.00 29.37 ? 608 HOH A O    1 
HETATM 5872 O O    . HOH B 2 .   ? -31.988 32.206 26.361  1.00 37.63 ? 609 HOH A O    1 
HETATM 5873 O O    . HOH B 2 .   ? -46.925 23.392 17.573  1.00 30.23 ? 610 HOH A O    1 
HETATM 5874 O O    . HOH B 2 .   ? -27.974 39.183 -5.563  1.00 13.81 ? 611 HOH A O    1 
HETATM 5875 O O    . HOH B 2 .   ? -21.933 8.418  3.229   1.00 22.64 ? 612 HOH A O    1 
HETATM 5876 O O    . HOH B 2 .   ? -41.103 62.810 9.822   1.00 29.37 ? 613 HOH A O    1 
HETATM 5877 O O    . HOH B 2 .   ? -19.485 46.229 4.464   1.00 26.48 ? 614 HOH A O    1 
HETATM 5878 O O    . HOH B 2 .   ? -24.077 9.615  6.010   1.00 28.37 ? 615 HOH A O    1 
HETATM 5879 O O    . HOH B 2 .   ? -61.490 36.313 15.984  1.00 29.88 ? 616 HOH A O    1 
HETATM 5880 O O    . HOH B 2 .   ? -52.690 22.448 19.647  1.00 24.75 ? 617 HOH A O    1 
HETATM 5881 O O    . HOH B 2 .   ? -38.956 41.015 -10.085 1.00 22.16 ? 618 HOH A O    1 
HETATM 5882 O O    . HOH B 2 .   ? -22.185 3.494  11.535  1.00 47.67 ? 619 HOH A O    1 
HETATM 5883 O O    . HOH B 2 .   ? -17.906 28.525 7.670   1.00 31.16 ? 620 HOH A O    1 
HETATM 5884 O O    . HOH B 2 .   ? -31.728 64.633 -1.266  1.00 45.83 ? 621 HOH A O    1 
HETATM 5885 O O    . HOH B 2 .   ? -44.188 37.779 11.576  1.00 14.80 ? 622 HOH A O    1 
HETATM 5886 O O    . HOH B 2 .   ? -33.813 64.568 0.713   1.00 39.17 ? 623 HOH A O    1 
HETATM 5887 O O    . HOH B 2 .   ? -17.343 47.617 13.788  1.00 33.70 ? 624 HOH A O    1 
HETATM 5888 O O    . HOH B 2 .   ? -46.250 51.138 -5.735  1.00 25.18 ? 625 HOH A O    1 
HETATM 5889 O O    . HOH B 2 .   ? -36.184 48.138 -7.404  1.00 26.74 ? 626 HOH A O    1 
HETATM 5890 O O    . HOH B 2 .   ? -33.852 53.389 16.259  1.00 20.18 ? 627 HOH A O    1 
HETATM 5891 O O    . HOH B 2 .   ? -30.041 57.743 -8.333  1.00 31.96 ? 628 HOH A O    1 
HETATM 5892 O O    . HOH B 2 .   ? -23.370 28.628 -3.856  1.00 35.83 ? 629 HOH A O    1 
HETATM 5893 O O    . HOH B 2 .   ? -11.215 15.982 5.508   1.00 35.28 ? 630 HOH A O    1 
HETATM 5894 O O    . HOH B 2 .   ? -32.707 51.729 17.792  1.00 30.64 ? 631 HOH A O    1 
HETATM 5895 O O    . HOH B 2 .   ? -62.080 33.297 15.271  1.00 26.95 ? 632 HOH A O    1 
HETATM 5896 O O    . HOH B 2 .   ? -40.119 57.726 11.568  1.00 31.50 ? 633 HOH A O    1 
HETATM 5897 O O    . HOH B 2 .   ? -48.475 32.089 -10.085 1.00 31.32 ? 634 HOH A O    1 
HETATM 5898 O O    . HOH B 2 .   ? -46.308 43.197 -7.713  1.00 21.22 ? 635 HOH A O    1 
HETATM 5899 O O    . HOH B 2 .   ? -48.029 39.519 18.505  1.00 27.91 ? 636 HOH A O    1 
HETATM 5900 O O    . HOH B 2 .   ? -27.951 29.244 -8.308  1.00 25.94 ? 637 HOH A O    1 
HETATM 5901 O O    . HOH B 2 .   ? -32.288 34.892 -10.607 1.00 33.56 ? 638 HOH A O    1 
HETATM 5902 O O    . HOH B 2 .   ? -47.419 40.579 -8.346  1.00 31.86 ? 639 HOH A O    1 
HETATM 5903 O O    . HOH B 2 .   ? -29.651 35.500 26.754  1.00 38.37 ? 640 HOH A O    1 
HETATM 5904 O O    . HOH B 2 .   ? -40.531 66.174 6.911   1.00 36.25 ? 641 HOH A O    1 
HETATM 5905 O O    . HOH B 2 .   ? -46.715 17.950 2.886   1.00 20.51 ? 642 HOH A O    1 
HETATM 5906 O O    . HOH B 2 .   ? -12.354 13.626 2.711   1.00 27.21 ? 643 HOH A O    1 
HETATM 5907 O O    . HOH B 2 .   ? -38.646 32.454 17.850  1.00 21.28 ? 644 HOH A O    1 
HETATM 5908 O O    . HOH B 2 .   ? -50.876 54.738 12.649  1.00 34.23 ? 645 HOH A O    1 
HETATM 5909 O O    . HOH B 2 .   ? -46.425 45.619 -0.706  1.00 24.86 ? 646 HOH A O    1 
HETATM 5910 O O    . HOH B 2 .   ? -44.537 46.934 19.924  1.00 28.61 ? 647 HOH A O    1 
HETATM 5911 O O    . HOH B 2 .   ? -42.112 18.737 19.355  1.00 34.19 ? 648 HOH A O    1 
HETATM 5912 O O    . HOH B 2 .   ? -31.331 62.210 0.629   1.00 41.03 ? 649 HOH A O    1 
HETATM 5913 O O    . HOH B 2 .   ? -40.636 16.926 -11.621 1.00 32.66 ? 650 HOH A O    1 
HETATM 5914 O O    . HOH B 2 .   ? -32.721 64.523 -4.128  1.00 46.41 ? 651 HOH A O    1 
HETATM 5915 O O    . HOH B 2 .   ? -43.625 36.729 14.391  1.00 16.95 ? 652 HOH A O    1 
HETATM 5916 O O    . HOH B 2 .   ? -53.634 18.885 1.261   1.00 32.14 ? 653 HOH A O    1 
HETATM 5917 O O    . HOH B 2 .   ? -28.813 18.001 22.773  1.00 31.72 ? 654 HOH A O    1 
HETATM 5918 O O    . HOH B 2 .   ? -61.866 34.710 8.745   1.00 30.25 ? 655 HOH A O    1 
HETATM 5919 O O    . HOH B 2 .   ? -38.345 19.486 9.833   1.00 18.91 ? 656 HOH A O    1 
HETATM 5920 O O    . HOH B 2 .   ? -18.022 61.405 5.584   1.00 21.70 ? 657 HOH A O    1 
HETATM 5921 O O    . HOH B 2 .   ? -46.990 37.183 -12.744 1.00 34.56 ? 658 HOH A O    1 
HETATM 5922 O O    . HOH B 2 .   ? -24.046 61.308 12.250  1.00 36.81 ? 659 HOH A O    1 
HETATM 5923 O O    . HOH B 2 .   ? -49.286 15.316 6.115   1.00 28.57 ? 660 HOH A O    1 
HETATM 5924 O O    . HOH B 2 .   ? -19.239 40.050 1.173   1.00 38.14 ? 661 HOH A O    1 
HETATM 5925 O O    . HOH B 2 .   ? -64.617 31.201 12.360  1.00 32.40 ? 662 HOH A O    1 
HETATM 5926 O O    . HOH B 2 .   ? -25.297 7.455  16.974  1.00 36.20 ? 663 HOH A O    1 
HETATM 5927 O O    . HOH B 2 .   ? -51.084 27.335 -8.546  1.00 34.99 ? 664 HOH A O    1 
HETATM 5928 O O    . HOH B 2 .   ? -16.698 43.827 11.514  1.00 38.14 ? 665 HOH A O    1 
HETATM 5929 O O    . HOH B 2 .   ? -38.756 43.427 -9.881  1.00 37.64 ? 666 HOH A O    1 
HETATM 5930 O O    . HOH B 2 .   ? -40.339 23.531 -13.160 1.00 35.86 ? 667 HOH A O    1 
HETATM 5931 O O    . HOH B 2 .   ? -18.078 13.525 15.744  1.00 34.06 ? 668 HOH A O    1 
HETATM 5932 O O    . HOH B 2 .   ? -44.321 42.070 10.468  1.00 30.77 ? 669 HOH A O    1 
HETATM 5933 O O    . HOH B 2 .   ? -17.990 42.615 5.540   1.00 31.37 ? 670 HOH A O    1 
HETATM 5934 O O    . HOH B 2 .   ? -21.458 16.690 16.418  1.00 34.15 ? 671 HOH A O    1 
HETATM 5935 O O    . HOH B 2 .   ? -53.762 18.925 4.579   1.00 35.28 ? 672 HOH A O    1 
HETATM 5936 O O    . HOH B 2 .   ? -21.159 22.372 -5.200  1.00 31.17 ? 673 HOH A O    1 
HETATM 5937 O O    . HOH B 2 .   ? -32.541 59.778 -9.576  1.00 39.24 ? 674 HOH A O    1 
HETATM 5938 O O    . HOH B 2 .   ? -31.976 46.990 14.928  1.00 20.36 ? 675 HOH A O    1 
HETATM 5939 O O    . HOH B 2 .   ? -19.524 48.109 14.780  1.00 34.06 ? 676 HOH A O    1 
HETATM 5940 O O    . HOH B 2 .   ? -25.412 33.839 12.653  1.00 30.81 ? 677 HOH A O    1 
HETATM 5941 O O    . HOH B 2 .   ? -19.471 58.033 8.502   1.00 21.76 ? 678 HOH A O    1 
HETATM 5942 O O    . HOH B 2 .   ? -13.719 23.711 2.113   1.00 39.41 ? 679 HOH A O    1 
HETATM 5943 O O    . HOH B 2 .   ? -58.965 27.570 11.125  1.00 26.52 ? 680 HOH A O    1 
HETATM 5944 O O    . HOH B 2 .   ? -33.759 48.874 24.622  1.00 31.06 ? 681 HOH A O    1 
HETATM 5945 O O    . HOH B 2 .   ? -36.055 28.278 -12.370 1.00 32.16 ? 682 HOH A O    1 
HETATM 5946 O O    . HOH B 2 .   ? -34.131 62.231 -5.217  1.00 40.46 ? 683 HOH A O    1 
HETATM 5947 O O    . HOH B 2 .   ? -31.990 55.388 16.203  1.00 31.02 ? 684 HOH A O    1 
HETATM 5948 O O    . HOH B 2 .   ? -19.322 23.880 13.981  1.00 41.41 ? 685 HOH A O    1 
HETATM 5949 O O    . HOH B 2 .   ? -51.885 18.771 22.259  1.00 34.19 ? 686 HOH A O    1 
HETATM 5950 O O    . HOH B 2 .   ? -35.166 51.449 24.527  1.00 34.41 ? 687 HOH A O    1 
HETATM 5951 O O    . HOH B 2 .   ? -48.532 17.589 17.757  1.00 35.80 ? 688 HOH A O    1 
HETATM 5952 O O    . HOH B 2 .   ? -46.302 20.815 15.398  1.00 26.30 ? 689 HOH A O    1 
HETATM 5953 O O    . HOH B 2 .   ? -35.897 31.325 9.651   1.00 30.44 ? 690 HOH A O    1 
HETATM 5954 O O    . HOH B 2 .   ? -28.993 41.469 23.184  1.00 39.66 ? 691 HOH A O    1 
HETATM 5955 O O    . HOH B 2 .   ? -22.163 25.763 -0.732  1.00 29.38 ? 692 HOH A O    1 
HETATM 5956 O O    . HOH B 2 .   ? -45.543 38.518 -10.861 1.00 33.74 ? 693 HOH A O    1 
HETATM 5957 O O    . HOH B 2 .   ? -27.030 30.766 2.097   1.00 32.84 ? 694 HOH A O    1 
HETATM 5958 O O    . HOH B 2 .   ? -25.109 16.769 19.312  1.00 41.22 ? 695 HOH A O    1 
HETATM 5959 O O    . HOH B 2 .   ? -33.992 9.112  -5.546  1.00 31.28 ? 696 HOH A O    1 
HETATM 5960 O O    . HOH B 2 .   ? -44.243 11.864 15.955  1.00 32.99 ? 697 HOH A O    1 
HETATM 5961 O O    . HOH B 2 .   ? -56.139 24.491 18.807  1.00 42.38 ? 698 HOH A O    1 
HETATM 5962 O O    . HOH B 2 .   ? -48.641 20.898 19.254  1.00 32.02 ? 699 HOH A O    1 
HETATM 5963 O O    . HOH B 2 .   ? -51.044 17.788 4.469   1.00 35.90 ? 700 HOH A O    1 
HETATM 5964 O O    . HOH B 2 .   ? -46.972 54.222 -4.175  1.00 26.16 ? 701 HOH A O    1 
HETATM 5965 O O    . HOH B 2 .   ? -37.554 7.768  -9.199  1.00 31.44 ? 702 HOH A O    1 
HETATM 5966 O O    . HOH B 2 .   ? -32.294 62.953 4.700   1.00 33.61 ? 703 HOH A O    1 
HETATM 5967 O O    . HOH B 2 .   ? -40.055 25.900 -14.011 1.00 34.11 ? 704 HOH A O    1 
HETATM 5968 O O    . HOH B 2 .   ? -26.223 41.191 -9.315  1.00 28.57 ? 705 HOH A O    1 
HETATM 5969 O O    . HOH B 2 .   ? -37.065 12.546 -8.271  1.00 31.65 ? 706 HOH A O    1 
HETATM 5970 O O    . HOH B 2 .   ? -42.020 55.120 20.489  1.00 32.88 ? 707 HOH A O    1 
HETATM 5971 O O    . HOH B 2 .   ? -25.956 6.530  4.277   1.00 31.12 ? 708 HOH A O    1 
HETATM 5972 O O    . HOH B 2 .   ? -18.878 16.608 -4.520  1.00 26.37 ? 709 HOH A O    1 
HETATM 5973 O O    . HOH B 2 .   ? -45.006 62.334 -6.208  1.00 33.25 ? 710 HOH A O    1 
HETATM 5974 O O    . HOH B 2 .   ? -28.868 43.749 -11.432 1.00 23.85 ? 711 HOH A O    1 
HETATM 5975 O O    . HOH B 2 .   ? -27.221 15.635 20.116  1.00 32.26 ? 712 HOH A O    1 
HETATM 5976 O O    . HOH B 2 .   ? -34.028 48.158 26.787  1.00 45.69 ? 713 HOH A O    1 
HETATM 5977 O O    . HOH B 2 .   ? -28.877 1.327  9.688   1.00 48.43 ? 714 HOH A O    1 
HETATM 5978 O O    . HOH B 2 .   ? -23.104 20.159 14.527  1.00 26.74 ? 715 HOH A O    1 
HETATM 5979 O O    . HOH B 2 .   ? -36.148 59.798 14.319  1.00 44.85 ? 716 HOH A O    1 
HETATM 5980 O O    . HOH B 2 .   ? -20.970 36.727 -0.601  1.00 32.89 ? 717 HOH A O    1 
HETATM 5981 O O    . HOH B 2 .   ? -50.249 32.503 19.974  1.00 37.77 ? 718 HOH A O    1 
HETATM 5982 O O    . HOH B 2 .   ? -45.970 18.822 17.043  1.00 30.20 ? 719 HOH A O    1 
HETATM 5983 O O    . HOH B 2 .   ? -25.629 49.599 -6.735  1.00 28.95 ? 720 HOH A O    1 
HETATM 5984 O O    . HOH B 2 .   ? -58.415 21.189 0.823   1.00 35.90 ? 721 HOH A O    1 
HETATM 5985 O O    . HOH B 2 .   ? -28.284 36.451 -8.879  1.00 31.90 ? 722 HOH A O    1 
HETATM 5986 O O    . HOH B 2 .   ? -39.509 9.102  -1.443  1.00 36.99 ? 723 HOH A O    1 
HETATM 5987 O O    . HOH B 2 .   ? -41.978 15.202 -5.515  1.00 23.69 ? 724 HOH A O    1 
HETATM 5988 O O    . HOH B 2 .   ? -34.396 18.287 -11.142 1.00 31.10 ? 725 HOH A O    1 
HETATM 5989 O O    . HOH B 2 .   ? -16.297 55.035 12.314  1.00 36.21 ? 726 HOH A O    1 
HETATM 5990 O O    . HOH B 2 .   ? -15.011 56.179 9.935   1.00 33.42 ? 727 HOH A O    1 
HETATM 5991 O O    . HOH B 2 .   ? -32.453 21.796 -13.055 1.00 41.54 ? 728 HOH A O    1 
HETATM 5992 O O    . HOH B 2 .   ? -37.143 49.965 -7.526  1.00 33.39 ? 729 HOH A O    1 
HETATM 5993 O O    . HOH B 2 .   ? -39.800 64.960 9.262   1.00 40.27 ? 730 HOH A O    1 
HETATM 5994 O O    . HOH B 2 .   ? -26.429 46.972 -6.119  1.00 22.73 ? 731 HOH A O    1 
HETATM 5995 O O    . HOH B 2 .   ? -16.998 59.033 8.289   1.00 32.50 ? 732 HOH A O    1 
HETATM 5996 O O    . HOH B 2 .   ? -56.641 42.748 15.024  1.00 40.04 ? 733 HOH A O    1 
HETATM 5997 O O    . HOH B 2 .   ? -54.999 40.695 15.886  1.00 35.70 ? 734 HOH A O    1 
HETATM 5998 O O    . HOH B 2 .   ? -31.746 46.803 27.419  1.00 38.21 ? 735 HOH A O    1 
HETATM 5999 O O    . HOH B 2 .   ? -15.918 30.208 6.984   1.00 42.15 ? 736 HOH A O    1 
HETATM 6000 O O    . HOH B 2 .   ? -49.179 19.155 3.025   1.00 24.21 ? 737 HOH A O    1 
HETATM 6001 O O    . HOH B 2 .   ? -27.400 15.878 22.777  1.00 24.84 ? 738 HOH A O    1 
HETATM 6002 O O    . HOH B 2 .   ? -19.342 21.330 14.528  1.00 40.19 ? 739 HOH A O    1 
HETATM 6003 O O    . HOH B 2 .   ? -38.017 6.303  -7.437  1.00 36.93 ? 740 HOH A O    1 
HETATM 6004 O O    . HOH B 2 .   ? -26.164 45.388 -8.318  1.00 30.95 ? 741 HOH A O    1 
HETATM 6005 O O    . HOH B 2 .   ? -34.853 65.769 -1.603  1.00 44.94 ? 742 HOH A O    1 
HETATM 6006 O O    . HOH B 2 .   ? -29.569 30.934 13.931  1.00 33.67 ? 743 HOH A O    1 
HETATM 6007 O O    . HOH B 2 .   ? -46.072 40.789 -10.836 1.00 39.46 ? 744 HOH A O    1 
HETATM 6008 O O    . HOH B 2 .   ? -36.601 64.101 -2.959  1.00 38.09 ? 745 HOH A O    1 
HETATM 6009 O O    . HOH B 2 .   ? -49.795 13.475 -2.501  1.00 41.01 ? 746 HOH A O    1 
HETATM 6010 O O    . HOH B 2 .   ? -33.727 62.085 15.192  1.00 43.14 ? 747 HOH A O    1 
HETATM 6011 O O    . HOH B 2 .   ? -46.201 12.675 -1.475  1.00 31.55 ? 748 HOH A O    1 
HETATM 6012 O O    . HOH B 2 .   ? -37.429 52.093 25.090  1.00 32.55 ? 749 HOH A O    1 
HETATM 6013 O O    . HOH B 2 .   ? -33.944 55.504 -9.380  1.00 32.47 ? 750 HOH A O    1 
HETATM 6014 O O    . HOH B 2 .   ? -28.535 23.691 -9.966  1.00 36.03 ? 751 HOH A O    1 
HETATM 6015 O O    . HOH B 2 .   ? -18.228 19.009 -5.471  1.00 29.47 ? 752 HOH A O    1 
HETATM 6016 O O    . HOH B 2 .   ? -23.863 31.955 11.107  1.00 33.22 ? 753 HOH A O    1 
HETATM 6017 O O    . HOH B 2 .   ? -24.562 37.906 -5.708  1.00 37.26 ? 754 HOH A O    1 
HETATM 6018 O O    . HOH B 2 .   ? -15.480 24.966 0.978   1.00 36.68 ? 755 HOH A O    1 
HETATM 6019 O O    . HOH B 2 .   ? -29.760 47.945 16.158  1.00 25.17 ? 756 HOH A O    1 
HETATM 6020 O O    . HOH B 2 .   ? -48.232 10.396 10.603  1.00 38.23 ? 757 HOH A O    1 
HETATM 6021 O O    . HOH B 2 .   ? -32.390 56.768 -10.054 1.00 38.89 ? 758 HOH A O    1 
HETATM 6022 O O    . HOH B 2 .   ? -64.870 35.464 3.985   1.00 40.94 ? 759 HOH A O    1 
HETATM 6023 O O    . HOH B 2 .   ? -48.828 24.401 -16.812 1.00 30.96 ? 760 HOH A O    1 
HETATM 6024 O O    . HOH B 2 .   ? -26.447 63.245 -1.752  1.00 32.90 ? 761 HOH A O    1 
HETATM 6025 O O    . HOH B 2 .   ? -29.558 46.476 -12.108 1.00 41.26 ? 762 HOH A O    1 
HETATM 6026 O O    . HOH B 2 .   ? -28.624 12.338 20.606  1.00 29.96 ? 763 HOH A O    1 
HETATM 6027 O O    . HOH B 2 .   ? -12.958 12.204 4.511   1.00 33.99 ? 764 HOH A O    1 
HETATM 6028 O O    . HOH B 2 .   ? -44.540 54.877 18.190  1.00 39.06 ? 765 HOH A O    1 
HETATM 6029 O O    . HOH B 2 .   ? -26.044 39.071 -7.503  1.00 29.14 ? 766 HOH A O    1 
HETATM 6030 O O    . HOH B 2 .   ? -48.060 56.533 -2.843  1.00 26.56 ? 767 HOH A O    1 
HETATM 6031 O O    . HOH B 2 .   ? -40.104 15.846 -9.059  1.00 28.08 ? 768 HOH A O    1 
HETATM 6032 O O    . HOH B 2 .   ? -55.715 39.030 18.232  1.00 39.75 ? 769 HOH A O    1 
HETATM 6033 O O    . HOH B 2 .   ? -39.098 28.272 -13.455 1.00 41.33 ? 770 HOH A O    1 
HETATM 6034 O O    . HOH B 2 .   ? -22.639 31.941 8.678   1.00 33.79 ? 771 HOH A O    1 
HETATM 6035 O O    . HOH B 2 .   ? -58.101 29.676 19.336  1.00 33.64 ? 772 HOH A O    1 
HETATM 6036 O O    . HOH B 2 .   ? -20.213 29.837 6.127   1.00 35.69 ? 773 HOH A O    1 
HETATM 6037 O O    . HOH B 2 .   ? -41.865 63.798 -5.874  1.00 35.70 ? 774 HOH A O    1 
HETATM 6038 O O    . HOH B 2 .   ? -36.015 16.636 -10.539 1.00 23.02 ? 775 HOH A O    1 
HETATM 6039 O O    . HOH B 2 .   ? -44.522 19.890 19.763  1.00 26.48 ? 776 HOH A O    1 
HETATM 6040 O O    . HOH B 2 .   ? -29.470 36.467 -10.685 1.00 33.60 ? 777 HOH A O    1 
HETATM 6041 O O    . HOH B 2 .   ? -30.128 19.980 -11.648 1.00 35.44 ? 778 HOH A O    1 
HETATM 6042 O O    . HOH B 2 .   ? -18.887 41.295 14.975  1.00 24.09 ? 779 HOH A O    1 
HETATM 6043 O O    . HOH B 2 .   ? -28.593 27.236 -7.028  1.00 31.63 ? 780 HOH A O    1 
HETATM 6044 O O    . HOH B 2 .   ? -16.908 61.616 8.053   1.00 35.52 ? 781 HOH A O    1 
HETATM 6045 O O    . HOH B 2 .   ? -17.864 13.052 -4.163  1.00 28.79 ? 782 HOH A O    1 
HETATM 6046 O O    . HOH B 2 .   ? -46.148 21.523 18.709  1.00 35.70 ? 783 HOH A O    1 
HETATM 6047 O O    . HOH B 2 .   ? -37.506 14.833 -6.730  1.00 22.81 ? 784 HOH A O    1 
HETATM 6048 O O    . HOH B 2 .   ? -55.193 16.111 13.092  1.00 42.71 ? 785 HOH A O    1 
HETATM 6049 O O    . HOH B 2 .   ? -12.996 5.972  -4.687  1.00 33.91 ? 786 HOH A O    1 
HETATM 6050 O O    . HOH B 2 .   ? -44.124 13.479 -5.028  1.00 26.54 ? 787 HOH A O    1 
HETATM 6051 O O    . HOH B 2 .   ? -42.295 15.564 -8.270  1.00 29.84 ? 788 HOH A O    1 
HETATM 6052 O O    . HOH B 2 .   ? -17.891 57.203 11.964  1.00 32.12 ? 789 HOH A O    1 
HETATM 6053 O O    . HOH B 2 .   ? -27.167 6.157  17.806  1.00 42.32 ? 790 HOH A O    1 
HETATM 6054 O O    . HOH B 2 .   ? -11.112 11.779 6.617   1.00 42.16 ? 791 HOH A O    1 
# 
