data_9JD5
# 
_entry.id   9JD5 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9JD5         pdb_00009jd5 10.2210/pdb9jd5/pdb 
WWPDB D_1300051016 ?            ?                   
EMDB  EMD-61381    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-03-19 ? 
2 'Structure model' 1 1 2025-05-07 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' 'Data collection'     
2 2 'Structure model' 'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
3 2 'Structure model' em_admin        
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation_author.identifier_ORCID' 
5 2 'Structure model' '_em_admin.last_update'             
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9JD5 
_pdbx_database_status.recvd_initial_deposition_date   2024-08-30 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        
'Cryo-EM structure of human TauT in presence of Taurocyamine, determined in an inward-facing occluded conformation' 
_pdbx_database_related.db_id          EMD-61381 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              qqh@fudan.edu.cn 
_pdbx_contact_author.name_first         Qianhui 
_pdbx_contact_author.name_last          Qu 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-5753-2599 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Qu, Q.'   1 0000-0002-5753-2599 
'Chao, Y.' 2 0009-0005-2230-1167 
'Zhou, Z.' 3 0000-0002-2432-4283 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   CN 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Cell Res.' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1001-0602 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            35 
_citation.language                  ? 
_citation.page_first                381 
_citation.page_last                 384 
_citation.title                     'Transport and inhibition mechanism for human TauT-mediated taurine uptake.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41422-025-01076-w 
_citation.pdbx_database_id_PubMed   39837997 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Chao, Y.'   1  ? 
primary 'Zhou, Z.'   2  ? 
primary 'Xia, H.'    3  ? 
primary 'Yang, C.'   4  ? 
primary 'Li, T.'     5  ? 
primary 'Tang, Y.Q.' 6  ? 
primary 'Shu, Y.'    7  ? 
primary 'Ba, Q.'     8  ? 
primary 'Hong, J.'   9  ? 
primary 'Li, D.'     10 ? 
primary 'Qu, Q.'     11 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Sodium- and chloride-dependent taurine transporter' 68495.992 1 ? ? ? ? 
2 non-polymer syn 2-acetamido-2-deoxy-beta-D-glucopyranose             221.208   3 ? ? ? ? 
3 non-polymer syn 'SODIUM ION'                                         22.990    2 ? ? ? ? 
4 non-polymer syn 'CHLORIDE ION'                                       35.453    1 ? ? ? ? 
5 non-polymer syn 'CHOLESTEROL HEMISUCCINATE'                          486.726   3 ? ? ? ? 
6 non-polymer nat Taurocyamine                                         167.187   1 ? ? ? ? 
7 water       nat water                                                18.015    1 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Solute carrier family 6 member 6' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MATKEKLQCLKDFHKDILKPSPGKSPGTRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFL
IPYFIFLFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWA
HCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLSLSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVR
STGKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKY
NSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGL
DSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIA
WIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVKYVPLTYNKTYVYPNWAIGLGWSLALSSMLCVPLV
IVIRLCQTEGPFLVRVKYLLTPSRLEEELRRRTEPGLRSRLEVLFQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MATKEKLQCLKDFHKDILKPSPGKSPGTRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFL
IPYFIFLFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWA
HCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLSLSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVR
STGKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKY
NSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGL
DSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIA
WIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVKYVPLTYNKTYVYPNWAIGLGWSLALSSMLCVPLV
IVIRLCQTEGPFLVRVKYLLTPSRLEEELRRRTEPGLRSRLEVLFQ
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 2-acetamido-2-deoxy-beta-D-glucopyranose NAG 
3 'SODIUM ION'                             NA  
4 'CHLORIDE ION'                           CL  
5 'CHOLESTEROL HEMISUCCINATE'              Y01 
6 Taurocyamine                             3S5 
7 water                                    HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   THR n 
1 4   LYS n 
1 5   GLU n 
1 6   LYS n 
1 7   LEU n 
1 8   GLN n 
1 9   CYS n 
1 10  LEU n 
1 11  LYS n 
1 12  ASP n 
1 13  PHE n 
1 14  HIS n 
1 15  LYS n 
1 16  ASP n 
1 17  ILE n 
1 18  LEU n 
1 19  LYS n 
1 20  PRO n 
1 21  SER n 
1 22  PRO n 
1 23  GLY n 
1 24  LYS n 
1 25  SER n 
1 26  PRO n 
1 27  GLY n 
1 28  THR n 
1 29  ARG n 
1 30  PRO n 
1 31  GLU n 
1 32  ASP n 
1 33  GLU n 
1 34  ALA n 
1 35  GLU n 
1 36  GLY n 
1 37  LYS n 
1 38  PRO n 
1 39  PRO n 
1 40  GLN n 
1 41  ARG n 
1 42  GLU n 
1 43  LYS n 
1 44  TRP n 
1 45  SER n 
1 46  SER n 
1 47  LYS n 
1 48  ILE n 
1 49  ASP n 
1 50  PHE n 
1 51  VAL n 
1 52  LEU n 
1 53  SER n 
1 54  VAL n 
1 55  ALA n 
1 56  GLY n 
1 57  GLY n 
1 58  PHE n 
1 59  VAL n 
1 60  GLY n 
1 61  LEU n 
1 62  GLY n 
1 63  ASN n 
1 64  VAL n 
1 65  TRP n 
1 66  ARG n 
1 67  PHE n 
1 68  PRO n 
1 69  TYR n 
1 70  LEU n 
1 71  CYS n 
1 72  TYR n 
1 73  LYS n 
1 74  ASN n 
1 75  GLY n 
1 76  GLY n 
1 77  GLY n 
1 78  ALA n 
1 79  PHE n 
1 80  LEU n 
1 81  ILE n 
1 82  PRO n 
1 83  TYR n 
1 84  PHE n 
1 85  ILE n 
1 86  PHE n 
1 87  LEU n 
1 88  PHE n 
1 89  GLY n 
1 90  SER n 
1 91  GLY n 
1 92  LEU n 
1 93  PRO n 
1 94  VAL n 
1 95  PHE n 
1 96  PHE n 
1 97  LEU n 
1 98  GLU n 
1 99  ILE n 
1 100 ILE n 
1 101 ILE n 
1 102 GLY n 
1 103 GLN n 
1 104 TYR n 
1 105 THR n 
1 106 SER n 
1 107 GLU n 
1 108 GLY n 
1 109 GLY n 
1 110 ILE n 
1 111 THR n 
1 112 CYS n 
1 113 TRP n 
1 114 GLU n 
1 115 LYS n 
1 116 ILE n 
1 117 CYS n 
1 118 PRO n 
1 119 LEU n 
1 120 PHE n 
1 121 SER n 
1 122 GLY n 
1 123 ILE n 
1 124 GLY n 
1 125 TYR n 
1 126 ALA n 
1 127 SER n 
1 128 VAL n 
1 129 VAL n 
1 130 ILE n 
1 131 VAL n 
1 132 SER n 
1 133 LEU n 
1 134 LEU n 
1 135 ASN n 
1 136 VAL n 
1 137 TYR n 
1 138 TYR n 
1 139 ILE n 
1 140 VAL n 
1 141 ILE n 
1 142 LEU n 
1 143 ALA n 
1 144 TRP n 
1 145 ALA n 
1 146 THR n 
1 147 TYR n 
1 148 TYR n 
1 149 LEU n 
1 150 PHE n 
1 151 GLN n 
1 152 SER n 
1 153 PHE n 
1 154 GLN n 
1 155 LYS n 
1 156 GLU n 
1 157 LEU n 
1 158 PRO n 
1 159 TRP n 
1 160 ALA n 
1 161 HIS n 
1 162 CYS n 
1 163 ASN n 
1 164 HIS n 
1 165 SER n 
1 166 TRP n 
1 167 ASN n 
1 168 THR n 
1 169 PRO n 
1 170 HIS n 
1 171 CYS n 
1 172 MET n 
1 173 GLU n 
1 174 ASP n 
1 175 THR n 
1 176 MET n 
1 177 ARG n 
1 178 LYS n 
1 179 ASN n 
1 180 LYS n 
1 181 SER n 
1 182 VAL n 
1 183 TRP n 
1 184 ILE n 
1 185 THR n 
1 186 ILE n 
1 187 SER n 
1 188 SER n 
1 189 THR n 
1 190 ASN n 
1 191 PHE n 
1 192 THR n 
1 193 SER n 
1 194 PRO n 
1 195 VAL n 
1 196 ILE n 
1 197 GLU n 
1 198 PHE n 
1 199 TRP n 
1 200 GLU n 
1 201 ARG n 
1 202 ASN n 
1 203 VAL n 
1 204 LEU n 
1 205 SER n 
1 206 LEU n 
1 207 SER n 
1 208 PRO n 
1 209 GLY n 
1 210 ILE n 
1 211 ASP n 
1 212 HIS n 
1 213 PRO n 
1 214 GLY n 
1 215 SER n 
1 216 LEU n 
1 217 LYS n 
1 218 TRP n 
1 219 ASP n 
1 220 LEU n 
1 221 ALA n 
1 222 LEU n 
1 223 CYS n 
1 224 LEU n 
1 225 LEU n 
1 226 LEU n 
1 227 VAL n 
1 228 TRP n 
1 229 LEU n 
1 230 VAL n 
1 231 CYS n 
1 232 PHE n 
1 233 PHE n 
1 234 CYS n 
1 235 ILE n 
1 236 TRP n 
1 237 LYS n 
1 238 GLY n 
1 239 VAL n 
1 240 ARG n 
1 241 SER n 
1 242 THR n 
1 243 GLY n 
1 244 LYS n 
1 245 VAL n 
1 246 VAL n 
1 247 TYR n 
1 248 PHE n 
1 249 THR n 
1 250 ALA n 
1 251 THR n 
1 252 PHE n 
1 253 PRO n 
1 254 PHE n 
1 255 ALA n 
1 256 MET n 
1 257 LEU n 
1 258 LEU n 
1 259 VAL n 
1 260 LEU n 
1 261 LEU n 
1 262 VAL n 
1 263 ARG n 
1 264 GLY n 
1 265 LEU n 
1 266 THR n 
1 267 LEU n 
1 268 PRO n 
1 269 GLY n 
1 270 ALA n 
1 271 GLY n 
1 272 ALA n 
1 273 GLY n 
1 274 ILE n 
1 275 LYS n 
1 276 PHE n 
1 277 TYR n 
1 278 LEU n 
1 279 TYR n 
1 280 PRO n 
1 281 ASP n 
1 282 ILE n 
1 283 THR n 
1 284 ARG n 
1 285 LEU n 
1 286 GLU n 
1 287 ASP n 
1 288 PRO n 
1 289 GLN n 
1 290 VAL n 
1 291 TRP n 
1 292 ILE n 
1 293 ASP n 
1 294 ALA n 
1 295 GLY n 
1 296 THR n 
1 297 GLN n 
1 298 ILE n 
1 299 PHE n 
1 300 PHE n 
1 301 SER n 
1 302 TYR n 
1 303 ALA n 
1 304 ILE n 
1 305 CYS n 
1 306 LEU n 
1 307 GLY n 
1 308 ALA n 
1 309 MET n 
1 310 THR n 
1 311 SER n 
1 312 LEU n 
1 313 GLY n 
1 314 SER n 
1 315 TYR n 
1 316 ASN n 
1 317 LYS n 
1 318 TYR n 
1 319 LYS n 
1 320 TYR n 
1 321 ASN n 
1 322 SER n 
1 323 TYR n 
1 324 ARG n 
1 325 ASP n 
1 326 CYS n 
1 327 MET n 
1 328 LEU n 
1 329 LEU n 
1 330 GLY n 
1 331 CYS n 
1 332 LEU n 
1 333 ASN n 
1 334 SER n 
1 335 GLY n 
1 336 THR n 
1 337 SER n 
1 338 PHE n 
1 339 VAL n 
1 340 SER n 
1 341 GLY n 
1 342 PHE n 
1 343 ALA n 
1 344 ILE n 
1 345 PHE n 
1 346 SER n 
1 347 ILE n 
1 348 LEU n 
1 349 GLY n 
1 350 PHE n 
1 351 MET n 
1 352 ALA n 
1 353 GLN n 
1 354 GLU n 
1 355 GLN n 
1 356 GLY n 
1 357 VAL n 
1 358 ASP n 
1 359 ILE n 
1 360 ALA n 
1 361 ASP n 
1 362 VAL n 
1 363 ALA n 
1 364 GLU n 
1 365 SER n 
1 366 GLY n 
1 367 PRO n 
1 368 GLY n 
1 369 LEU n 
1 370 ALA n 
1 371 PHE n 
1 372 ILE n 
1 373 ALA n 
1 374 TYR n 
1 375 PRO n 
1 376 LYS n 
1 377 ALA n 
1 378 VAL n 
1 379 THR n 
1 380 MET n 
1 381 MET n 
1 382 PRO n 
1 383 LEU n 
1 384 PRO n 
1 385 THR n 
1 386 PHE n 
1 387 TRP n 
1 388 SER n 
1 389 ILE n 
1 390 LEU n 
1 391 PHE n 
1 392 PHE n 
1 393 ILE n 
1 394 MET n 
1 395 LEU n 
1 396 LEU n 
1 397 LEU n 
1 398 LEU n 
1 399 GLY n 
1 400 LEU n 
1 401 ASP n 
1 402 SER n 
1 403 GLN n 
1 404 PHE n 
1 405 VAL n 
1 406 GLU n 
1 407 VAL n 
1 408 GLU n 
1 409 GLY n 
1 410 GLN n 
1 411 ILE n 
1 412 THR n 
1 413 SER n 
1 414 LEU n 
1 415 VAL n 
1 416 ASP n 
1 417 LEU n 
1 418 TYR n 
1 419 PRO n 
1 420 SER n 
1 421 PHE n 
1 422 LEU n 
1 423 ARG n 
1 424 LYS n 
1 425 GLY n 
1 426 TYR n 
1 427 ARG n 
1 428 ARG n 
1 429 GLU n 
1 430 ILE n 
1 431 PHE n 
1 432 ILE n 
1 433 ALA n 
1 434 PHE n 
1 435 VAL n 
1 436 CYS n 
1 437 SER n 
1 438 ILE n 
1 439 SER n 
1 440 TYR n 
1 441 LEU n 
1 442 LEU n 
1 443 GLY n 
1 444 LEU n 
1 445 THR n 
1 446 MET n 
1 447 VAL n 
1 448 THR n 
1 449 GLU n 
1 450 GLY n 
1 451 GLY n 
1 452 MET n 
1 453 TYR n 
1 454 VAL n 
1 455 PHE n 
1 456 GLN n 
1 457 LEU n 
1 458 PHE n 
1 459 ASP n 
1 460 TYR n 
1 461 TYR n 
1 462 ALA n 
1 463 ALA n 
1 464 SER n 
1 465 GLY n 
1 466 VAL n 
1 467 CYS n 
1 468 LEU n 
1 469 LEU n 
1 470 TRP n 
1 471 VAL n 
1 472 ALA n 
1 473 PHE n 
1 474 PHE n 
1 475 GLU n 
1 476 CYS n 
1 477 PHE n 
1 478 VAL n 
1 479 ILE n 
1 480 ALA n 
1 481 TRP n 
1 482 ILE n 
1 483 TYR n 
1 484 GLY n 
1 485 GLY n 
1 486 ASP n 
1 487 ASN n 
1 488 LEU n 
1 489 TYR n 
1 490 ASP n 
1 491 GLY n 
1 492 ILE n 
1 493 GLU n 
1 494 ASP n 
1 495 MET n 
1 496 ILE n 
1 497 GLY n 
1 498 TYR n 
1 499 ARG n 
1 500 PRO n 
1 501 GLY n 
1 502 PRO n 
1 503 TRP n 
1 504 MET n 
1 505 LYS n 
1 506 TYR n 
1 507 SER n 
1 508 TRP n 
1 509 ALA n 
1 510 VAL n 
1 511 ILE n 
1 512 THR n 
1 513 PRO n 
1 514 VAL n 
1 515 LEU n 
1 516 CYS n 
1 517 VAL n 
1 518 GLY n 
1 519 CYS n 
1 520 PHE n 
1 521 ILE n 
1 522 PHE n 
1 523 SER n 
1 524 LEU n 
1 525 VAL n 
1 526 LYS n 
1 527 TYR n 
1 528 VAL n 
1 529 PRO n 
1 530 LEU n 
1 531 THR n 
1 532 TYR n 
1 533 ASN n 
1 534 LYS n 
1 535 THR n 
1 536 TYR n 
1 537 VAL n 
1 538 TYR n 
1 539 PRO n 
1 540 ASN n 
1 541 TRP n 
1 542 ALA n 
1 543 ILE n 
1 544 GLY n 
1 545 LEU n 
1 546 GLY n 
1 547 TRP n 
1 548 SER n 
1 549 LEU n 
1 550 ALA n 
1 551 LEU n 
1 552 SER n 
1 553 SER n 
1 554 MET n 
1 555 LEU n 
1 556 CYS n 
1 557 VAL n 
1 558 PRO n 
1 559 LEU n 
1 560 VAL n 
1 561 ILE n 
1 562 VAL n 
1 563 ILE n 
1 564 ARG n 
1 565 LEU n 
1 566 CYS n 
1 567 GLN n 
1 568 THR n 
1 569 GLU n 
1 570 GLY n 
1 571 PRO n 
1 572 PHE n 
1 573 LEU n 
1 574 VAL n 
1 575 ARG n 
1 576 VAL n 
1 577 LYS n 
1 578 TYR n 
1 579 LEU n 
1 580 LEU n 
1 581 THR n 
1 582 PRO n 
1 583 SER n 
1 584 ARG n 
1 585 LEU n 
1 586 GLU n 
1 587 GLU n 
1 588 GLU n 
1 589 LEU n 
1 590 ARG n 
1 591 ARG n 
1 592 ARG n 
1 593 THR n 
1 594 GLU n 
1 595 PRO n 
1 596 GLY n 
1 597 LEU n 
1 598 ARG n 
1 599 SER n 
1 600 ARG n 
1 601 LEU n 
1 602 GLU n 
1 603 VAL n 
1 604 LEU n 
1 605 PHE n 
1 606 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   606 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 SLC6A6 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               human 
_entity_src_gen.pdbx_host_org_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     9606 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            HEK293F 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
3S5 non-polymer                  . Taurocyamine                             '2-carbamimidamidoethanesulfonic acid' 'C3 H9 N3 O3 S' 
167.187 
ALA 'L-peptide linking'          y ALANINE                                  ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking'          y ARGININE                                 ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking'          y ASPARAGINE                               ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking'          y 'ASPARTIC ACID'                          ? 'C4 H7 N O4'     133.103 
CL  non-polymer                  . 'CHLORIDE ION'                           ? 'Cl -1'          35.453  
CYS 'L-peptide linking'          y CYSTEINE                                 ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking'          y GLUTAMINE                                ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking'          y 'GLUTAMIC ACID'                          ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'            y GLYCINE                                  ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking'          y HISTIDINE                                ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer                  . WATER                                    ? 'H2 O'           18.015  
ILE 'L-peptide linking'          y ISOLEUCINE                               ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking'          y LEUCINE                                  ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking'          y LYSINE                                   ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking'          y METHIONINE                               ? 'C5 H11 N O2 S'  149.211 
NA  non-polymer                  . 'SODIUM ION'                             ? 'Na 1'           22.990  
NAG 'D-saccharide, beta linking' . 2-acetamido-2-deoxy-beta-D-glucopyranose 
;N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE
;
'C8 H15 N O6'    221.208 
PHE 'L-peptide linking'          y PHENYLALANINE                            ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking'          y PROLINE                                  ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking'          y SERINE                                   ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking'          y THREONINE                                ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking'          y TRYPTOPHAN                               ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking'          y TYROSINE                                 ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking'          y VALINE                                   ? 'C5 H11 N O2'    117.146 
Y01 non-polymer                  . 'CHOLESTEROL HEMISUCCINATE'              ? 'C31 H50 O4'     486.726 
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
NAG 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DGlcpNAcb                      
NAG 'COMMON NAME'                         GMML     1.0 N-acetyl-b-D-glucopyranosamine 
NAG 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-GlcpNAc                    
NAG 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 GlcNAc                         
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   ALA 2   2   ?   ?   ?   A . n 
A 1 3   THR 3   3   ?   ?   ?   A . n 
A 1 4   LYS 4   4   ?   ?   ?   A . n 
A 1 5   GLU 5   5   ?   ?   ?   A . n 
A 1 6   LYS 6   6   ?   ?   ?   A . n 
A 1 7   LEU 7   7   ?   ?   ?   A . n 
A 1 8   GLN 8   8   ?   ?   ?   A . n 
A 1 9   CYS 9   9   ?   ?   ?   A . n 
A 1 10  LEU 10  10  ?   ?   ?   A . n 
A 1 11  LYS 11  11  ?   ?   ?   A . n 
A 1 12  ASP 12  12  ?   ?   ?   A . n 
A 1 13  PHE 13  13  ?   ?   ?   A . n 
A 1 14  HIS 14  14  ?   ?   ?   A . n 
A 1 15  LYS 15  15  ?   ?   ?   A . n 
A 1 16  ASP 16  16  ?   ?   ?   A . n 
A 1 17  ILE 17  17  ?   ?   ?   A . n 
A 1 18  LEU 18  18  ?   ?   ?   A . n 
A 1 19  LYS 19  19  ?   ?   ?   A . n 
A 1 20  PRO 20  20  ?   ?   ?   A . n 
A 1 21  SER 21  21  ?   ?   ?   A . n 
A 1 22  PRO 22  22  ?   ?   ?   A . n 
A 1 23  GLY 23  23  ?   ?   ?   A . n 
A 1 24  LYS 24  24  ?   ?   ?   A . n 
A 1 25  SER 25  25  ?   ?   ?   A . n 
A 1 26  PRO 26  26  ?   ?   ?   A . n 
A 1 27  GLY 27  27  ?   ?   ?   A . n 
A 1 28  THR 28  28  ?   ?   ?   A . n 
A 1 29  ARG 29  29  ?   ?   ?   A . n 
A 1 30  PRO 30  30  ?   ?   ?   A . n 
A 1 31  GLU 31  31  ?   ?   ?   A . n 
A 1 32  ASP 32  32  ?   ?   ?   A . n 
A 1 33  GLU 33  33  ?   ?   ?   A . n 
A 1 34  ALA 34  34  ?   ?   ?   A . n 
A 1 35  GLU 35  35  ?   ?   ?   A . n 
A 1 36  GLY 36  36  ?   ?   ?   A . n 
A 1 37  LYS 37  37  ?   ?   ?   A . n 
A 1 38  PRO 38  38  ?   ?   ?   A . n 
A 1 39  PRO 39  39  ?   ?   ?   A . n 
A 1 40  GLN 40  40  ?   ?   ?   A . n 
A 1 41  ARG 41  41  41  ARG ARG A . n 
A 1 42  GLU 42  42  42  GLU GLU A . n 
A 1 43  LYS 43  43  43  LYS LYS A . n 
A 1 44  TRP 44  44  44  TRP TRP A . n 
A 1 45  SER 45  45  45  SER SER A . n 
A 1 46  SER 46  46  46  SER SER A . n 
A 1 47  LYS 47  47  47  LYS LYS A . n 
A 1 48  ILE 48  48  48  ILE ILE A . n 
A 1 49  ASP 49  49  49  ASP ASP A . n 
A 1 50  PHE 50  50  50  PHE PHE A . n 
A 1 51  VAL 51  51  51  VAL VAL A . n 
A 1 52  LEU 52  52  52  LEU LEU A . n 
A 1 53  SER 53  53  53  SER SER A . n 
A 1 54  VAL 54  54  54  VAL VAL A . n 
A 1 55  ALA 55  55  55  ALA ALA A . n 
A 1 56  GLY 56  56  56  GLY GLY A . n 
A 1 57  GLY 57  57  57  GLY GLY A . n 
A 1 58  PHE 58  58  58  PHE PHE A . n 
A 1 59  VAL 59  59  59  VAL VAL A . n 
A 1 60  GLY 60  60  60  GLY GLY A . n 
A 1 61  LEU 61  61  61  LEU LEU A . n 
A 1 62  GLY 62  62  62  GLY GLY A . n 
A 1 63  ASN 63  63  63  ASN ASN A . n 
A 1 64  VAL 64  64  64  VAL VAL A . n 
A 1 65  TRP 65  65  65  TRP TRP A . n 
A 1 66  ARG 66  66  66  ARG ARG A . n 
A 1 67  PHE 67  67  67  PHE PHE A . n 
A 1 68  PRO 68  68  68  PRO PRO A . n 
A 1 69  TYR 69  69  69  TYR TYR A . n 
A 1 70  LEU 70  70  70  LEU LEU A . n 
A 1 71  CYS 71  71  71  CYS CYS A . n 
A 1 72  TYR 72  72  72  TYR TYR A . n 
A 1 73  LYS 73  73  73  LYS LYS A . n 
A 1 74  ASN 74  74  74  ASN ASN A . n 
A 1 75  GLY 75  75  75  GLY GLY A . n 
A 1 76  GLY 76  76  76  GLY GLY A . n 
A 1 77  GLY 77  77  77  GLY GLY A . n 
A 1 78  ALA 78  78  78  ALA ALA A . n 
A 1 79  PHE 79  79  79  PHE PHE A . n 
A 1 80  LEU 80  80  80  LEU LEU A . n 
A 1 81  ILE 81  81  81  ILE ILE A . n 
A 1 82  PRO 82  82  82  PRO PRO A . n 
A 1 83  TYR 83  83  83  TYR TYR A . n 
A 1 84  PHE 84  84  84  PHE PHE A . n 
A 1 85  ILE 85  85  85  ILE ILE A . n 
A 1 86  PHE 86  86  86  PHE PHE A . n 
A 1 87  LEU 87  87  87  LEU LEU A . n 
A 1 88  PHE 88  88  88  PHE PHE A . n 
A 1 89  GLY 89  89  89  GLY GLY A . n 
A 1 90  SER 90  90  90  SER SER A . n 
A 1 91  GLY 91  91  91  GLY GLY A . n 
A 1 92  LEU 92  92  92  LEU LEU A . n 
A 1 93  PRO 93  93  93  PRO PRO A . n 
A 1 94  VAL 94  94  94  VAL VAL A . n 
A 1 95  PHE 95  95  95  PHE PHE A . n 
A 1 96  PHE 96  96  96  PHE PHE A . n 
A 1 97  LEU 97  97  97  LEU LEU A . n 
A 1 98  GLU 98  98  98  GLU GLU A . n 
A 1 99  ILE 99  99  99  ILE ILE A . n 
A 1 100 ILE 100 100 100 ILE ILE A . n 
A 1 101 ILE 101 101 101 ILE ILE A . n 
A 1 102 GLY 102 102 102 GLY GLY A . n 
A 1 103 GLN 103 103 103 GLN GLN A . n 
A 1 104 TYR 104 104 104 TYR TYR A . n 
A 1 105 THR 105 105 105 THR THR A . n 
A 1 106 SER 106 106 106 SER SER A . n 
A 1 107 GLU 107 107 107 GLU GLU A . n 
A 1 108 GLY 108 108 108 GLY GLY A . n 
A 1 109 GLY 109 109 109 GLY GLY A . n 
A 1 110 ILE 110 110 110 ILE ILE A . n 
A 1 111 THR 111 111 111 THR THR A . n 
A 1 112 CYS 112 112 112 CYS CYS A . n 
A 1 113 TRP 113 113 113 TRP TRP A . n 
A 1 114 GLU 114 114 114 GLU GLU A . n 
A 1 115 LYS 115 115 115 LYS LYS A . n 
A 1 116 ILE 116 116 116 ILE ILE A . n 
A 1 117 CYS 117 117 117 CYS CYS A . n 
A 1 118 PRO 118 118 118 PRO PRO A . n 
A 1 119 LEU 119 119 119 LEU LEU A . n 
A 1 120 PHE 120 120 120 PHE PHE A . n 
A 1 121 SER 121 121 121 SER SER A . n 
A 1 122 GLY 122 122 122 GLY GLY A . n 
A 1 123 ILE 123 123 123 ILE ILE A . n 
A 1 124 GLY 124 124 124 GLY GLY A . n 
A 1 125 TYR 125 125 125 TYR TYR A . n 
A 1 126 ALA 126 126 126 ALA ALA A . n 
A 1 127 SER 127 127 127 SER SER A . n 
A 1 128 VAL 128 128 128 VAL VAL A . n 
A 1 129 VAL 129 129 129 VAL VAL A . n 
A 1 130 ILE 130 130 130 ILE ILE A . n 
A 1 131 VAL 131 131 131 VAL VAL A . n 
A 1 132 SER 132 132 132 SER SER A . n 
A 1 133 LEU 133 133 133 LEU LEU A . n 
A 1 134 LEU 134 134 134 LEU LEU A . n 
A 1 135 ASN 135 135 135 ASN ASN A . n 
A 1 136 VAL 136 136 136 VAL VAL A . n 
A 1 137 TYR 137 137 137 TYR TYR A . n 
A 1 138 TYR 138 138 138 TYR TYR A . n 
A 1 139 ILE 139 139 139 ILE ILE A . n 
A 1 140 VAL 140 140 140 VAL VAL A . n 
A 1 141 ILE 141 141 141 ILE ILE A . n 
A 1 142 LEU 142 142 142 LEU LEU A . n 
A 1 143 ALA 143 143 143 ALA ALA A . n 
A 1 144 TRP 144 144 144 TRP TRP A . n 
A 1 145 ALA 145 145 145 ALA ALA A . n 
A 1 146 THR 146 146 146 THR THR A . n 
A 1 147 TYR 147 147 147 TYR TYR A . n 
A 1 148 TYR 148 148 148 TYR TYR A . n 
A 1 149 LEU 149 149 149 LEU LEU A . n 
A 1 150 PHE 150 150 150 PHE PHE A . n 
A 1 151 GLN 151 151 151 GLN GLN A . n 
A 1 152 SER 152 152 152 SER SER A . n 
A 1 153 PHE 153 153 153 PHE PHE A . n 
A 1 154 GLN 154 154 154 GLN GLN A . n 
A 1 155 LYS 155 155 155 LYS LYS A . n 
A 1 156 GLU 156 156 156 GLU GLU A . n 
A 1 157 LEU 157 157 157 LEU LEU A . n 
A 1 158 PRO 158 158 158 PRO PRO A . n 
A 1 159 TRP 159 159 159 TRP TRP A . n 
A 1 160 ALA 160 160 160 ALA ALA A . n 
A 1 161 HIS 161 161 161 HIS HIS A . n 
A 1 162 CYS 162 162 162 CYS CYS A . n 
A 1 163 ASN 163 163 163 ASN ASN A . n 
A 1 164 HIS 164 164 164 HIS HIS A . n 
A 1 165 SER 165 165 165 SER SER A . n 
A 1 166 TRP 166 166 166 TRP TRP A . n 
A 1 167 ASN 167 167 167 ASN ASN A . n 
A 1 168 THR 168 168 168 THR THR A . n 
A 1 169 PRO 169 169 169 PRO PRO A . n 
A 1 170 HIS 170 170 170 HIS HIS A . n 
A 1 171 CYS 171 171 171 CYS CYS A . n 
A 1 172 MET 172 172 172 MET MET A . n 
A 1 173 GLU 173 173 173 GLU GLU A . n 
A 1 174 ASP 174 174 174 ASP ASP A . n 
A 1 175 THR 175 175 175 THR THR A . n 
A 1 176 MET 176 176 176 MET MET A . n 
A 1 177 ARG 177 177 177 ARG ARG A . n 
A 1 178 LYS 178 178 178 LYS LYS A . n 
A 1 179 ASN 179 179 179 ASN ASN A . n 
A 1 180 LYS 180 180 180 LYS LYS A . n 
A 1 181 SER 181 181 181 SER SER A . n 
A 1 182 VAL 182 182 182 VAL VAL A . n 
A 1 183 TRP 183 183 183 TRP TRP A . n 
A 1 184 ILE 184 184 184 ILE ILE A . n 
A 1 185 THR 185 185 185 THR THR A . n 
A 1 186 ILE 186 186 186 ILE ILE A . n 
A 1 187 SER 187 187 187 SER SER A . n 
A 1 188 SER 188 188 188 SER SER A . n 
A 1 189 THR 189 189 189 THR THR A . n 
A 1 190 ASN 190 190 190 ASN ASN A . n 
A 1 191 PHE 191 191 191 PHE PHE A . n 
A 1 192 THR 192 192 192 THR THR A . n 
A 1 193 SER 193 193 193 SER SER A . n 
A 1 194 PRO 194 194 194 PRO PRO A . n 
A 1 195 VAL 195 195 195 VAL VAL A . n 
A 1 196 ILE 196 196 196 ILE ILE A . n 
A 1 197 GLU 197 197 197 GLU GLU A . n 
A 1 198 PHE 198 198 198 PHE PHE A . n 
A 1 199 TRP 199 199 199 TRP TRP A . n 
A 1 200 GLU 200 200 200 GLU GLU A . n 
A 1 201 ARG 201 201 201 ARG ARG A . n 
A 1 202 ASN 202 202 202 ASN ASN A . n 
A 1 203 VAL 203 203 203 VAL VAL A . n 
A 1 204 LEU 204 204 204 LEU LEU A . n 
A 1 205 SER 205 205 205 SER SER A . n 
A 1 206 LEU 206 206 206 LEU LEU A . n 
A 1 207 SER 207 207 207 SER SER A . n 
A 1 208 PRO 208 208 208 PRO PRO A . n 
A 1 209 GLY 209 209 209 GLY GLY A . n 
A 1 210 ILE 210 210 210 ILE ILE A . n 
A 1 211 ASP 211 211 211 ASP ASP A . n 
A 1 212 HIS 212 212 212 HIS HIS A . n 
A 1 213 PRO 213 213 213 PRO PRO A . n 
A 1 214 GLY 214 214 214 GLY GLY A . n 
A 1 215 SER 215 215 215 SER SER A . n 
A 1 216 LEU 216 216 216 LEU LEU A . n 
A 1 217 LYS 217 217 217 LYS LYS A . n 
A 1 218 TRP 218 218 218 TRP TRP A . n 
A 1 219 ASP 219 219 219 ASP ASP A . n 
A 1 220 LEU 220 220 220 LEU LEU A . n 
A 1 221 ALA 221 221 221 ALA ALA A . n 
A 1 222 LEU 222 222 222 LEU LEU A . n 
A 1 223 CYS 223 223 223 CYS CYS A . n 
A 1 224 LEU 224 224 224 LEU LEU A . n 
A 1 225 LEU 225 225 225 LEU LEU A . n 
A 1 226 LEU 226 226 226 LEU LEU A . n 
A 1 227 VAL 227 227 227 VAL VAL A . n 
A 1 228 TRP 228 228 228 TRP TRP A . n 
A 1 229 LEU 229 229 229 LEU LEU A . n 
A 1 230 VAL 230 230 230 VAL VAL A . n 
A 1 231 CYS 231 231 231 CYS CYS A . n 
A 1 232 PHE 232 232 232 PHE PHE A . n 
A 1 233 PHE 233 233 233 PHE PHE A . n 
A 1 234 CYS 234 234 234 CYS CYS A . n 
A 1 235 ILE 235 235 235 ILE ILE A . n 
A 1 236 TRP 236 236 236 TRP TRP A . n 
A 1 237 LYS 237 237 237 LYS LYS A . n 
A 1 238 GLY 238 238 238 GLY GLY A . n 
A 1 239 VAL 239 239 239 VAL VAL A . n 
A 1 240 ARG 240 240 240 ARG ARG A . n 
A 1 241 SER 241 241 241 SER SER A . n 
A 1 242 THR 242 242 242 THR THR A . n 
A 1 243 GLY 243 243 243 GLY GLY A . n 
A 1 244 LYS 244 244 244 LYS LYS A . n 
A 1 245 VAL 245 245 245 VAL VAL A . n 
A 1 246 VAL 246 246 246 VAL VAL A . n 
A 1 247 TYR 247 247 247 TYR TYR A . n 
A 1 248 PHE 248 248 248 PHE PHE A . n 
A 1 249 THR 249 249 249 THR THR A . n 
A 1 250 ALA 250 250 250 ALA ALA A . n 
A 1 251 THR 251 251 251 THR THR A . n 
A 1 252 PHE 252 252 252 PHE PHE A . n 
A 1 253 PRO 253 253 253 PRO PRO A . n 
A 1 254 PHE 254 254 254 PHE PHE A . n 
A 1 255 ALA 255 255 255 ALA ALA A . n 
A 1 256 MET 256 256 256 MET MET A . n 
A 1 257 LEU 257 257 257 LEU LEU A . n 
A 1 258 LEU 258 258 258 LEU LEU A . n 
A 1 259 VAL 259 259 259 VAL VAL A . n 
A 1 260 LEU 260 260 260 LEU LEU A . n 
A 1 261 LEU 261 261 261 LEU LEU A . n 
A 1 262 VAL 262 262 262 VAL VAL A . n 
A 1 263 ARG 263 263 263 ARG ARG A . n 
A 1 264 GLY 264 264 264 GLY GLY A . n 
A 1 265 LEU 265 265 265 LEU LEU A . n 
A 1 266 THR 266 266 266 THR THR A . n 
A 1 267 LEU 267 267 267 LEU LEU A . n 
A 1 268 PRO 268 268 268 PRO PRO A . n 
A 1 269 GLY 269 269 269 GLY GLY A . n 
A 1 270 ALA 270 270 270 ALA ALA A . n 
A 1 271 GLY 271 271 271 GLY GLY A . n 
A 1 272 ALA 272 272 272 ALA ALA A . n 
A 1 273 GLY 273 273 273 GLY GLY A . n 
A 1 274 ILE 274 274 274 ILE ILE A . n 
A 1 275 LYS 275 275 275 LYS LYS A . n 
A 1 276 PHE 276 276 276 PHE PHE A . n 
A 1 277 TYR 277 277 277 TYR TYR A . n 
A 1 278 LEU 278 278 278 LEU LEU A . n 
A 1 279 TYR 279 279 279 TYR TYR A . n 
A 1 280 PRO 280 280 280 PRO PRO A . n 
A 1 281 ASP 281 281 281 ASP ASP A . n 
A 1 282 ILE 282 282 282 ILE ILE A . n 
A 1 283 THR 283 283 283 THR THR A . n 
A 1 284 ARG 284 284 284 ARG ARG A . n 
A 1 285 LEU 285 285 285 LEU LEU A . n 
A 1 286 GLU 286 286 286 GLU GLU A . n 
A 1 287 ASP 287 287 287 ASP ASP A . n 
A 1 288 PRO 288 288 288 PRO PRO A . n 
A 1 289 GLN 289 289 289 GLN GLN A . n 
A 1 290 VAL 290 290 290 VAL VAL A . n 
A 1 291 TRP 291 291 291 TRP TRP A . n 
A 1 292 ILE 292 292 292 ILE ILE A . n 
A 1 293 ASP 293 293 293 ASP ASP A . n 
A 1 294 ALA 294 294 294 ALA ALA A . n 
A 1 295 GLY 295 295 295 GLY GLY A . n 
A 1 296 THR 296 296 296 THR THR A . n 
A 1 297 GLN 297 297 297 GLN GLN A . n 
A 1 298 ILE 298 298 298 ILE ILE A . n 
A 1 299 PHE 299 299 299 PHE PHE A . n 
A 1 300 PHE 300 300 300 PHE PHE A . n 
A 1 301 SER 301 301 301 SER SER A . n 
A 1 302 TYR 302 302 302 TYR TYR A . n 
A 1 303 ALA 303 303 303 ALA ALA A . n 
A 1 304 ILE 304 304 304 ILE ILE A . n 
A 1 305 CYS 305 305 305 CYS CYS A . n 
A 1 306 LEU 306 306 306 LEU LEU A . n 
A 1 307 GLY 307 307 307 GLY GLY A . n 
A 1 308 ALA 308 308 308 ALA ALA A . n 
A 1 309 MET 309 309 309 MET MET A . n 
A 1 310 THR 310 310 310 THR THR A . n 
A 1 311 SER 311 311 311 SER SER A . n 
A 1 312 LEU 312 312 312 LEU LEU A . n 
A 1 313 GLY 313 313 313 GLY GLY A . n 
A 1 314 SER 314 314 314 SER SER A . n 
A 1 315 TYR 315 315 315 TYR TYR A . n 
A 1 316 ASN 316 316 316 ASN ASN A . n 
A 1 317 LYS 317 317 317 LYS LYS A . n 
A 1 318 TYR 318 318 318 TYR TYR A . n 
A 1 319 LYS 319 319 319 LYS LYS A . n 
A 1 320 TYR 320 320 320 TYR TYR A . n 
A 1 321 ASN 321 321 321 ASN ASN A . n 
A 1 322 SER 322 322 322 SER SER A . n 
A 1 323 TYR 323 323 323 TYR TYR A . n 
A 1 324 ARG 324 324 324 ARG ARG A . n 
A 1 325 ASP 325 325 325 ASP ASP A . n 
A 1 326 CYS 326 326 326 CYS CYS A . n 
A 1 327 MET 327 327 327 MET MET A . n 
A 1 328 LEU 328 328 328 LEU LEU A . n 
A 1 329 LEU 329 329 329 LEU LEU A . n 
A 1 330 GLY 330 330 330 GLY GLY A . n 
A 1 331 CYS 331 331 331 CYS CYS A . n 
A 1 332 LEU 332 332 332 LEU LEU A . n 
A 1 333 ASN 333 333 333 ASN ASN A . n 
A 1 334 SER 334 334 334 SER SER A . n 
A 1 335 GLY 335 335 335 GLY GLY A . n 
A 1 336 THR 336 336 336 THR THR A . n 
A 1 337 SER 337 337 337 SER SER A . n 
A 1 338 PHE 338 338 338 PHE PHE A . n 
A 1 339 VAL 339 339 339 VAL VAL A . n 
A 1 340 SER 340 340 340 SER SER A . n 
A 1 341 GLY 341 341 341 GLY GLY A . n 
A 1 342 PHE 342 342 342 PHE PHE A . n 
A 1 343 ALA 343 343 343 ALA ALA A . n 
A 1 344 ILE 344 344 344 ILE ILE A . n 
A 1 345 PHE 345 345 345 PHE PHE A . n 
A 1 346 SER 346 346 346 SER SER A . n 
A 1 347 ILE 347 347 347 ILE ILE A . n 
A 1 348 LEU 348 348 348 LEU LEU A . n 
A 1 349 GLY 349 349 349 GLY GLY A . n 
A 1 350 PHE 350 350 350 PHE PHE A . n 
A 1 351 MET 351 351 351 MET MET A . n 
A 1 352 ALA 352 352 352 ALA ALA A . n 
A 1 353 GLN 353 353 353 GLN GLN A . n 
A 1 354 GLU 354 354 354 GLU GLU A . n 
A 1 355 GLN 355 355 355 GLN GLN A . n 
A 1 356 GLY 356 356 356 GLY GLY A . n 
A 1 357 VAL 357 357 357 VAL VAL A . n 
A 1 358 ASP 358 358 358 ASP ASP A . n 
A 1 359 ILE 359 359 359 ILE ILE A . n 
A 1 360 ALA 360 360 360 ALA ALA A . n 
A 1 361 ASP 361 361 361 ASP ASP A . n 
A 1 362 VAL 362 362 362 VAL VAL A . n 
A 1 363 ALA 363 363 363 ALA ALA A . n 
A 1 364 GLU 364 364 364 GLU GLU A . n 
A 1 365 SER 365 365 365 SER SER A . n 
A 1 366 GLY 366 366 366 GLY GLY A . n 
A 1 367 PRO 367 367 367 PRO PRO A . n 
A 1 368 GLY 368 368 368 GLY GLY A . n 
A 1 369 LEU 369 369 369 LEU LEU A . n 
A 1 370 ALA 370 370 370 ALA ALA A . n 
A 1 371 PHE 371 371 371 PHE PHE A . n 
A 1 372 ILE 372 372 372 ILE ILE A . n 
A 1 373 ALA 373 373 373 ALA ALA A . n 
A 1 374 TYR 374 374 374 TYR TYR A . n 
A 1 375 PRO 375 375 375 PRO PRO A . n 
A 1 376 LYS 376 376 376 LYS LYS A . n 
A 1 377 ALA 377 377 377 ALA ALA A . n 
A 1 378 VAL 378 378 378 VAL VAL A . n 
A 1 379 THR 379 379 379 THR THR A . n 
A 1 380 MET 380 380 380 MET MET A . n 
A 1 381 MET 381 381 381 MET MET A . n 
A 1 382 PRO 382 382 382 PRO PRO A . n 
A 1 383 LEU 383 383 383 LEU LEU A . n 
A 1 384 PRO 384 384 384 PRO PRO A . n 
A 1 385 THR 385 385 385 THR THR A . n 
A 1 386 PHE 386 386 386 PHE PHE A . n 
A 1 387 TRP 387 387 387 TRP TRP A . n 
A 1 388 SER 388 388 388 SER SER A . n 
A 1 389 ILE 389 389 389 ILE ILE A . n 
A 1 390 LEU 390 390 390 LEU LEU A . n 
A 1 391 PHE 391 391 391 PHE PHE A . n 
A 1 392 PHE 392 392 392 PHE PHE A . n 
A 1 393 ILE 393 393 393 ILE ILE A . n 
A 1 394 MET 394 394 394 MET MET A . n 
A 1 395 LEU 395 395 395 LEU LEU A . n 
A 1 396 LEU 396 396 396 LEU LEU A . n 
A 1 397 LEU 397 397 397 LEU LEU A . n 
A 1 398 LEU 398 398 398 LEU LEU A . n 
A 1 399 GLY 399 399 399 GLY GLY A . n 
A 1 400 LEU 400 400 400 LEU LEU A . n 
A 1 401 ASP 401 401 401 ASP ASP A . n 
A 1 402 SER 402 402 402 SER SER A . n 
A 1 403 GLN 403 403 403 GLN GLN A . n 
A 1 404 PHE 404 404 404 PHE PHE A . n 
A 1 405 VAL 405 405 405 VAL VAL A . n 
A 1 406 GLU 406 406 406 GLU GLU A . n 
A 1 407 VAL 407 407 407 VAL VAL A . n 
A 1 408 GLU 408 408 408 GLU GLU A . n 
A 1 409 GLY 409 409 409 GLY GLY A . n 
A 1 410 GLN 410 410 410 GLN GLN A . n 
A 1 411 ILE 411 411 411 ILE ILE A . n 
A 1 412 THR 412 412 412 THR THR A . n 
A 1 413 SER 413 413 413 SER SER A . n 
A 1 414 LEU 414 414 414 LEU LEU A . n 
A 1 415 VAL 415 415 415 VAL VAL A . n 
A 1 416 ASP 416 416 416 ASP ASP A . n 
A 1 417 LEU 417 417 417 LEU LEU A . n 
A 1 418 TYR 418 418 418 TYR TYR A . n 
A 1 419 PRO 419 419 419 PRO PRO A . n 
A 1 420 SER 420 420 420 SER SER A . n 
A 1 421 PHE 421 421 421 PHE PHE A . n 
A 1 422 LEU 422 422 422 LEU LEU A . n 
A 1 423 ARG 423 423 423 ARG ARG A . n 
A 1 424 LYS 424 424 424 LYS LYS A . n 
A 1 425 GLY 425 425 425 GLY GLY A . n 
A 1 426 TYR 426 426 426 TYR TYR A . n 
A 1 427 ARG 427 427 427 ARG ARG A . n 
A 1 428 ARG 428 428 428 ARG ARG A . n 
A 1 429 GLU 429 429 429 GLU GLU A . n 
A 1 430 ILE 430 430 430 ILE ILE A . n 
A 1 431 PHE 431 431 431 PHE PHE A . n 
A 1 432 ILE 432 432 432 ILE ILE A . n 
A 1 433 ALA 433 433 433 ALA ALA A . n 
A 1 434 PHE 434 434 434 PHE PHE A . n 
A 1 435 VAL 435 435 435 VAL VAL A . n 
A 1 436 CYS 436 436 436 CYS CYS A . n 
A 1 437 SER 437 437 437 SER SER A . n 
A 1 438 ILE 438 438 438 ILE ILE A . n 
A 1 439 SER 439 439 439 SER SER A . n 
A 1 440 TYR 440 440 440 TYR TYR A . n 
A 1 441 LEU 441 441 441 LEU LEU A . n 
A 1 442 LEU 442 442 442 LEU LEU A . n 
A 1 443 GLY 443 443 443 GLY GLY A . n 
A 1 444 LEU 444 444 444 LEU LEU A . n 
A 1 445 THR 445 445 445 THR THR A . n 
A 1 446 MET 446 446 446 MET MET A . n 
A 1 447 VAL 447 447 447 VAL VAL A . n 
A 1 448 THR 448 448 448 THR THR A . n 
A 1 449 GLU 449 449 449 GLU GLU A . n 
A 1 450 GLY 450 450 450 GLY GLY A . n 
A 1 451 GLY 451 451 451 GLY GLY A . n 
A 1 452 MET 452 452 452 MET MET A . n 
A 1 453 TYR 453 453 453 TYR TYR A . n 
A 1 454 VAL 454 454 454 VAL VAL A . n 
A 1 455 PHE 455 455 455 PHE PHE A . n 
A 1 456 GLN 456 456 456 GLN GLN A . n 
A 1 457 LEU 457 457 457 LEU LEU A . n 
A 1 458 PHE 458 458 458 PHE PHE A . n 
A 1 459 ASP 459 459 459 ASP ASP A . n 
A 1 460 TYR 460 460 460 TYR TYR A . n 
A 1 461 TYR 461 461 461 TYR TYR A . n 
A 1 462 ALA 462 462 462 ALA ALA A . n 
A 1 463 ALA 463 463 463 ALA ALA A . n 
A 1 464 SER 464 464 464 SER SER A . n 
A 1 465 GLY 465 465 465 GLY GLY A . n 
A 1 466 VAL 466 466 466 VAL VAL A . n 
A 1 467 CYS 467 467 467 CYS CYS A . n 
A 1 468 LEU 468 468 468 LEU LEU A . n 
A 1 469 LEU 469 469 469 LEU LEU A . n 
A 1 470 TRP 470 470 470 TRP TRP A . n 
A 1 471 VAL 471 471 471 VAL VAL A . n 
A 1 472 ALA 472 472 472 ALA ALA A . n 
A 1 473 PHE 473 473 473 PHE PHE A . n 
A 1 474 PHE 474 474 474 PHE PHE A . n 
A 1 475 GLU 475 475 475 GLU GLU A . n 
A 1 476 CYS 476 476 476 CYS CYS A . n 
A 1 477 PHE 477 477 477 PHE PHE A . n 
A 1 478 VAL 478 478 478 VAL VAL A . n 
A 1 479 ILE 479 479 479 ILE ILE A . n 
A 1 480 ALA 480 480 480 ALA ALA A . n 
A 1 481 TRP 481 481 481 TRP TRP A . n 
A 1 482 ILE 482 482 482 ILE ILE A . n 
A 1 483 TYR 483 483 483 TYR TYR A . n 
A 1 484 GLY 484 484 484 GLY GLY A . n 
A 1 485 GLY 485 485 485 GLY GLY A . n 
A 1 486 ASP 486 486 486 ASP ASP A . n 
A 1 487 ASN 487 487 487 ASN ASN A . n 
A 1 488 LEU 488 488 488 LEU LEU A . n 
A 1 489 TYR 489 489 489 TYR TYR A . n 
A 1 490 ASP 490 490 490 ASP ASP A . n 
A 1 491 GLY 491 491 491 GLY GLY A . n 
A 1 492 ILE 492 492 492 ILE ILE A . n 
A 1 493 GLU 493 493 493 GLU GLU A . n 
A 1 494 ASP 494 494 494 ASP ASP A . n 
A 1 495 MET 495 495 495 MET MET A . n 
A 1 496 ILE 496 496 496 ILE ILE A . n 
A 1 497 GLY 497 497 497 GLY GLY A . n 
A 1 498 TYR 498 498 498 TYR TYR A . n 
A 1 499 ARG 499 499 499 ARG ARG A . n 
A 1 500 PRO 500 500 500 PRO PRO A . n 
A 1 501 GLY 501 501 501 GLY GLY A . n 
A 1 502 PRO 502 502 502 PRO PRO A . n 
A 1 503 TRP 503 503 503 TRP TRP A . n 
A 1 504 MET 504 504 504 MET MET A . n 
A 1 505 LYS 505 505 505 LYS LYS A . n 
A 1 506 TYR 506 506 506 TYR TYR A . n 
A 1 507 SER 507 507 507 SER SER A . n 
A 1 508 TRP 508 508 508 TRP TRP A . n 
A 1 509 ALA 509 509 509 ALA ALA A . n 
A 1 510 VAL 510 510 510 VAL VAL A . n 
A 1 511 ILE 511 511 511 ILE ILE A . n 
A 1 512 THR 512 512 512 THR THR A . n 
A 1 513 PRO 513 513 513 PRO PRO A . n 
A 1 514 VAL 514 514 514 VAL VAL A . n 
A 1 515 LEU 515 515 515 LEU LEU A . n 
A 1 516 CYS 516 516 516 CYS CYS A . n 
A 1 517 VAL 517 517 517 VAL VAL A . n 
A 1 518 GLY 518 518 518 GLY GLY A . n 
A 1 519 CYS 519 519 519 CYS CYS A . n 
A 1 520 PHE 520 520 520 PHE PHE A . n 
A 1 521 ILE 521 521 521 ILE ILE A . n 
A 1 522 PHE 522 522 522 PHE PHE A . n 
A 1 523 SER 523 523 523 SER SER A . n 
A 1 524 LEU 524 524 524 LEU LEU A . n 
A 1 525 VAL 525 525 525 VAL VAL A . n 
A 1 526 LYS 526 526 526 LYS LYS A . n 
A 1 527 TYR 527 527 527 TYR TYR A . n 
A 1 528 VAL 528 528 528 VAL VAL A . n 
A 1 529 PRO 529 529 529 PRO PRO A . n 
A 1 530 LEU 530 530 530 LEU LEU A . n 
A 1 531 THR 531 531 531 THR THR A . n 
A 1 532 TYR 532 532 532 TYR TYR A . n 
A 1 533 ASN 533 533 533 ASN ASN A . n 
A 1 534 LYS 534 534 534 LYS LYS A . n 
A 1 535 THR 535 535 535 THR THR A . n 
A 1 536 TYR 536 536 536 TYR TYR A . n 
A 1 537 VAL 537 537 537 VAL VAL A . n 
A 1 538 TYR 538 538 538 TYR TYR A . n 
A 1 539 PRO 539 539 539 PRO PRO A . n 
A 1 540 ASN 540 540 540 ASN ASN A . n 
A 1 541 TRP 541 541 541 TRP TRP A . n 
A 1 542 ALA 542 542 542 ALA ALA A . n 
A 1 543 ILE 543 543 543 ILE ILE A . n 
A 1 544 GLY 544 544 544 GLY GLY A . n 
A 1 545 LEU 545 545 545 LEU LEU A . n 
A 1 546 GLY 546 546 546 GLY GLY A . n 
A 1 547 TRP 547 547 547 TRP TRP A . n 
A 1 548 SER 548 548 548 SER SER A . n 
A 1 549 LEU 549 549 549 LEU LEU A . n 
A 1 550 ALA 550 550 550 ALA ALA A . n 
A 1 551 LEU 551 551 551 LEU LEU A . n 
A 1 552 SER 552 552 552 SER SER A . n 
A 1 553 SER 553 553 553 SER SER A . n 
A 1 554 MET 554 554 554 MET MET A . n 
A 1 555 LEU 555 555 555 LEU LEU A . n 
A 1 556 CYS 556 556 556 CYS CYS A . n 
A 1 557 VAL 557 557 557 VAL VAL A . n 
A 1 558 PRO 558 558 558 PRO PRO A . n 
A 1 559 LEU 559 559 559 LEU LEU A . n 
A 1 560 VAL 560 560 560 VAL VAL A . n 
A 1 561 ILE 561 561 561 ILE ILE A . n 
A 1 562 VAL 562 562 562 VAL VAL A . n 
A 1 563 ILE 563 563 563 ILE ILE A . n 
A 1 564 ARG 564 564 564 ARG ARG A . n 
A 1 565 LEU 565 565 565 LEU LEU A . n 
A 1 566 CYS 566 566 566 CYS CYS A . n 
A 1 567 GLN 567 567 567 GLN GLN A . n 
A 1 568 THR 568 568 ?   ?   ?   A . n 
A 1 569 GLU 569 569 ?   ?   ?   A . n 
A 1 570 GLY 570 570 ?   ?   ?   A . n 
A 1 571 PRO 571 571 ?   ?   ?   A . n 
A 1 572 PHE 572 572 ?   ?   ?   A . n 
A 1 573 LEU 573 573 ?   ?   ?   A . n 
A 1 574 VAL 574 574 ?   ?   ?   A . n 
A 1 575 ARG 575 575 ?   ?   ?   A . n 
A 1 576 VAL 576 576 ?   ?   ?   A . n 
A 1 577 LYS 577 577 ?   ?   ?   A . n 
A 1 578 TYR 578 578 ?   ?   ?   A . n 
A 1 579 LEU 579 579 ?   ?   ?   A . n 
A 1 580 LEU 580 580 ?   ?   ?   A . n 
A 1 581 THR 581 581 ?   ?   ?   A . n 
A 1 582 PRO 582 582 ?   ?   ?   A . n 
A 1 583 SER 583 583 ?   ?   ?   A . n 
A 1 584 ARG 584 584 ?   ?   ?   A . n 
A 1 585 LEU 585 585 ?   ?   ?   A . n 
A 1 586 GLU 586 586 ?   ?   ?   A . n 
A 1 587 GLU 587 587 ?   ?   ?   A . n 
A 1 588 GLU 588 588 ?   ?   ?   A . n 
A 1 589 LEU 589 589 ?   ?   ?   A . n 
A 1 590 ARG 590 590 ?   ?   ?   A . n 
A 1 591 ARG 591 591 ?   ?   ?   A . n 
A 1 592 ARG 592 592 ?   ?   ?   A . n 
A 1 593 THR 593 593 ?   ?   ?   A . n 
A 1 594 GLU 594 594 ?   ?   ?   A . n 
A 1 595 PRO 595 595 ?   ?   ?   A . n 
A 1 596 GLY 596 596 ?   ?   ?   A . n 
A 1 597 LEU 597 597 ?   ?   ?   A . n 
A 1 598 ARG 598 598 ?   ?   ?   A . n 
A 1 599 SER 599 599 ?   ?   ?   A . n 
A 1 600 ARG 600 600 ?   ?   ?   A . n 
A 1 601 LEU 601 601 ?   ?   ?   A . n 
A 1 602 GLU 602 602 ?   ?   ?   A . n 
A 1 603 VAL 603 603 ?   ?   ?   A . n 
A 1 604 LEU 604 604 ?   ?   ?   A . n 
A 1 605 PHE 605 605 ?   ?   ?   A . n 
A 1 606 GLN 606 606 ?   ?   ?   A . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 CL  ? ? CL  ? ? 'SUBJECT OF INVESTIGATION' ? 
2 3S5 ? ? 3S5 ? ? 'SUBJECT OF INVESTIGATION' ? 
3 NAG ? ? NAG ? ? 'SUBJECT OF INVESTIGATION' ? 
4 NA  ? ? NA  ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 NAG 1 701 568 NAG NAG A . 
C 2 NAG 1 702 569 NAG NAG A . 
D 2 NAG 1 703 570 NAG NAG A . 
E 3 NA  1 704 571 NA  NA  A . 
F 3 NA  1 705 572 NA  NA  A . 
G 4 CL  1 706 573 CL  CL  A . 
H 5 Y01 1 707 575 Y01 Y01 A . 
I 5 Y01 1 708 576 Y01 Y01 A . 
J 5 Y01 1 709 577 Y01 Y01 A . 
K 6 3S5 1 710 1   3S5 GES A . 
L 7 HOH 1 801 574 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A ARG 240 ? CG  ? A ARG 240 CG  
2 1 Y 1 A ARG 240 ? CD  ? A ARG 240 CD  
3 1 Y 1 A ARG 240 ? NE  ? A ARG 240 NE  
4 1 Y 1 A ARG 240 ? CZ  ? A ARG 240 CZ  
5 1 Y 1 A ARG 240 ? NH1 ? A ARG 240 NH1 
6 1 Y 1 A ARG 240 ? NH2 ? A ARG 240 NH2 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9JD5 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9JD5 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9JD5 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.entry_id                                 9JD5 
_refine.pdbx_diffrn_id                           ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             ? 
_refine.ls_d_res_high                            . 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.B_iso_mean                               ? 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.details                                  ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.overall_SU_ML                            ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.003 ? 4491 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 0.559 ? 6141 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 8.321 ? 681  ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.041 ? 693  ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.005 ? 732  ? f_plane_restr      ? ? 
# 
_struct.entry_id                     9JD5 
_struct.title                        
'Cryo-EM structure of human TauT in presence of Taurocyamine, determined in an inward-facing occluded conformation' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9JD5 
_struct_keywords.text            
'Human Taurine transporter, taurocyamine, complex, inward-facing occluded conformation, TRANSPORT PROTEIN' 
_struct_keywords.pdbx_keywords   'TRANSPORT PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 2 ? 
E N N 3 ? 
F N N 3 ? 
G N N 4 ? 
H N N 5 ? 
I N N 5 ? 
J N N 5 ? 
K N N 6 ? 
L N N 7 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    SC6A6_HUMAN 
_struct_ref.pdbx_db_accession          P31641 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MATKEKLQCLKDFHKDILKPSPGKSPGTRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFL
IPYFIFLFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWA
HCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLSLSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVR
STGKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKY
NSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGL
DSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIA
WIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVKYVPLTYNKTYVYPNWAIGLGWSLALSSMLCVPLV
IVIRLCQTEGPFLVRVKYLLTP
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9JD5 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 582 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P31641 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  582 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       582 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9JD5 SER A 583 ? UNP P31641 ? ? 'expression tag' 583 1  
1 9JD5 ARG A 584 ? UNP P31641 ? ? 'expression tag' 584 2  
1 9JD5 LEU A 585 ? UNP P31641 ? ? 'expression tag' 585 3  
1 9JD5 GLU A 586 ? UNP P31641 ? ? 'expression tag' 586 4  
1 9JD5 GLU A 587 ? UNP P31641 ? ? 'expression tag' 587 5  
1 9JD5 GLU A 588 ? UNP P31641 ? ? 'expression tag' 588 6  
1 9JD5 LEU A 589 ? UNP P31641 ? ? 'expression tag' 589 7  
1 9JD5 ARG A 590 ? UNP P31641 ? ? 'expression tag' 590 8  
1 9JD5 ARG A 591 ? UNP P31641 ? ? 'expression tag' 591 9  
1 9JD5 ARG A 592 ? UNP P31641 ? ? 'expression tag' 592 10 
1 9JD5 THR A 593 ? UNP P31641 ? ? 'expression tag' 593 11 
1 9JD5 GLU A 594 ? UNP P31641 ? ? 'expression tag' 594 12 
1 9JD5 PRO A 595 ? UNP P31641 ? ? 'expression tag' 595 13 
1 9JD5 GLY A 596 ? UNP P31641 ? ? 'expression tag' 596 14 
1 9JD5 LEU A 597 ? UNP P31641 ? ? 'expression tag' 597 15 
1 9JD5 ARG A 598 ? UNP P31641 ? ? 'expression tag' 598 16 
1 9JD5 SER A 599 ? UNP P31641 ? ? 'expression tag' 599 17 
1 9JD5 ARG A 600 ? UNP P31641 ? ? 'expression tag' 600 18 
1 9JD5 LEU A 601 ? UNP P31641 ? ? 'expression tag' 601 19 
1 9JD5 GLU A 602 ? UNP P31641 ? ? 'expression tag' 602 20 
1 9JD5 VAL A 603 ? UNP P31641 ? ? 'expression tag' 603 21 
1 9JD5 LEU A 604 ? UNP P31641 ? ? 'expression tag' 604 22 
1 9JD5 PHE A 605 ? UNP P31641 ? ? 'expression tag' 605 23 
1 9JD5 GLN A 606 ? UNP P31641 ? ? 'expression tag' 606 24 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 46  ? PHE A 58  ? SER A 46  PHE A 58  1 ? 13 
HELX_P HELX_P2  AA2 GLY A 60  ? TRP A 65  ? GLY A 60  TRP A 65  1 ? 6  
HELX_P HELX_P3  AA3 TRP A 65  ? ASN A 74  ? TRP A 65  ASN A 74  1 ? 10 
HELX_P HELX_P4  AA4 PHE A 79  ? SER A 106 ? PHE A 79  SER A 106 1 ? 28 
HELX_P HELX_P5  AA5 ILE A 110 ? LYS A 115 ? ILE A 110 LYS A 115 5 ? 6  
HELX_P HELX_P6  AA6 CYS A 117 ? PHE A 120 ? CYS A 117 PHE A 120 5 ? 4  
HELX_P HELX_P7  AA7 SER A 121 ? PHE A 153 ? SER A 121 PHE A 153 1 ? 33 
HELX_P HELX_P8  AA8 LEU A 157 ? HIS A 161 ? LEU A 157 HIS A 161 5 ? 5  
HELX_P HELX_P9  AA9 GLU A 173 ? LYS A 178 ? GLU A 173 LYS A 178 1 ? 6  
HELX_P HELX_P10 AB1 SER A 193 ? ASN A 202 ? SER A 193 ASN A 202 1 ? 10 
HELX_P HELX_P11 AB2 LYS A 217 ? LYS A 237 ? LYS A 217 LYS A 237 1 ? 21 
HELX_P HELX_P12 AB3 VAL A 245 ? ALA A 250 ? VAL A 245 ALA A 250 1 ? 6  
HELX_P HELX_P13 AB4 THR A 251 ? THR A 266 ? THR A 251 THR A 266 1 ? 16 
HELX_P HELX_P14 AB5 GLY A 269 ? TYR A 279 ? GLY A 269 TYR A 279 1 ? 11 
HELX_P HELX_P15 AB6 ASP A 281 ? GLU A 286 ? ASP A 281 GLU A 286 5 ? 6  
HELX_P HELX_P16 AB7 ASP A 287 ? TYR A 302 ? ASP A 287 TYR A 302 1 ? 16 
HELX_P HELX_P17 AB8 ALA A 308 ? GLY A 313 ? ALA A 308 GLY A 313 1 ? 6  
HELX_P HELX_P18 AB9 SER A 314 ? ASN A 316 ? SER A 314 ASN A 316 5 ? 3  
HELX_P HELX_P19 AC1 SER A 322 ? GLY A 356 ? SER A 322 GLY A 356 1 ? 35 
HELX_P HELX_P20 AC2 ASP A 358 ? VAL A 362 ? ASP A 358 VAL A 362 5 ? 5  
HELX_P HELX_P21 AC3 LEU A 369 ? THR A 379 ? LEU A 369 THR A 379 1 ? 11 
HELX_P HELX_P22 AC4 LEU A 383 ? ASP A 416 ? LEU A 383 ASP A 416 1 ? 34 
HELX_P HELX_P23 AC5 GLY A 425 ? LEU A 444 ? GLY A 425 LEU A 444 1 ? 20 
HELX_P HELX_P24 AC6 THR A 445 ? VAL A 447 ? THR A 445 VAL A 447 5 ? 3  
HELX_P HELX_P25 AC7 GLY A 450 ? ALA A 462 ? GLY A 450 ALA A 462 1 ? 13 
HELX_P HELX_P26 AC8 GLY A 465 ? ILE A 482 ? GLY A 465 ILE A 482 1 ? 18 
HELX_P HELX_P27 AC9 GLY A 484 ? GLY A 497 ? GLY A 484 GLY A 497 1 ? 14 
HELX_P HELX_P28 AD1 PRO A 502 ? LYS A 526 ? PRO A 502 LYS A 526 1 ? 25 
HELX_P HELX_P29 AD2 PRO A 539 ? LEU A 555 ? PRO A 539 LEU A 555 1 ? 17 
HELX_P HELX_P30 AD3 LEU A 555 ? GLN A 567 ? LEU A 555 GLN A 567 1 ? 13 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ?   ? A CYS 162 SG  ? ? ? 1_555 A CYS 171 SG  ? ? A CYS 162 A CYS 171 1_555 ? ? ? ? ? ? ? 2.036 ? ?               
covale1 covale one ? A ASN 163 ND2 ? ? ? 1_555 B NAG .   C1  ? ? A ASN 163 A NAG 701 1_555 ? ? ? ? ? ? ? 1.446 ? N-Glycosylation 
covale2 covale one ? A ASN 179 ND2 ? ? ? 1_555 C NAG .   C1  ? ? A ASN 179 A NAG 702 1_555 ? ? ? ? ? ? ? 1.440 ? N-Glycosylation 
covale3 covale one ? A ASN 190 ND2 ? ? ? 1_555 D NAG .   C1  ? ? A ASN 190 A NAG 703 1_555 ? ? ? ? ? ? ? 1.440 ? N-Glycosylation 
metalc1 metalc ?   ? A GLY 56  O   ? ? ? 1_555 E NA  .   NA  ? ? A GLY 56  A NA  704 1_555 ? ? ? ? ? ? ? 2.610 ? ?               
metalc2 metalc ?   ? A PHE 58  O   ? ? ? 1_555 F NA  .   NA  ? ? A PHE 58  A NA  705 1_555 ? ? ? ? ? ? ? 2.381 ? ?               
metalc3 metalc ?   ? A VAL 59  O   ? ? ? 1_555 E NA  .   NA  ? ? A VAL 59  A NA  704 1_555 ? ? ? ? ? ? ? 2.185 ? ?               
metalc4 metalc ?   ? A ASN 63  OD1 ? ? ? 1_555 F NA  .   NA  ? ? A ASN 63  A NA  705 1_555 ? ? ? ? ? ? ? 1.957 ? ?               
metalc5 metalc ?   ? A SER 301 O   ? ? ? 1_555 F NA  .   NA  ? ? A SER 301 A NA  705 1_555 ? ? ? ? ? ? ? 2.585 ? ?               
metalc6 metalc ?   ? A ASP 401 OD1 ? ? ? 1_555 E NA  .   NA  ? ? A ASP 401 A NA  704 1_555 ? ? ? ? ? ? ? 2.802 ? ?               
metalc7 metalc ?   ? A ASP 401 OD2 ? ? ? 1_555 E NA  .   NA  ? ? A ASP 401 A NA  704 1_555 ? ? ? ? ? ? ? 2.198 ? ?               
metalc8 metalc ?   ? A SER 402 OG  ? ? ? 1_555 E NA  .   NA  ? ? A SER 402 A NA  704 1_555 ? ? ? ? ? ? ? 2.844 ? ?               
metalc9 metalc ?   ? F NA  .   NA  ? ? ? 1_555 K 3S5 .   O09 ? ? A NA  705 A 3S5 710 1_555 ? ? ? ? ? ? ? 2.075 ? ?               
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
covale ? ? 
metalc ? ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  O   ? A GLY 56  ? A GLY 56  ? 1_555 NA ? E NA . ? A NA 704 ? 1_555 O   ? A VAL 59  ? A VAL 59  ? 1_555 111.5 ? 
2  O   ? A GLY 56  ? A GLY 56  ? 1_555 NA ? E NA . ? A NA 704 ? 1_555 OD1 ? A ASP 401 ? A ASP 401 ? 1_555 78.3  ? 
3  O   ? A VAL 59  ? A VAL 59  ? 1_555 NA ? E NA . ? A NA 704 ? 1_555 OD1 ? A ASP 401 ? A ASP 401 ? 1_555 145.6 ? 
4  O   ? A GLY 56  ? A GLY 56  ? 1_555 NA ? E NA . ? A NA 704 ? 1_555 OD2 ? A ASP 401 ? A ASP 401 ? 1_555 97.6  ? 
5  O   ? A VAL 59  ? A VAL 59  ? 1_555 NA ? E NA . ? A NA 704 ? 1_555 OD2 ? A ASP 401 ? A ASP 401 ? 1_555 148.8 ? 
6  OD1 ? A ASP 401 ? A ASP 401 ? 1_555 NA ? E NA . ? A NA 704 ? 1_555 OD2 ? A ASP 401 ? A ASP 401 ? 1_555 49.9  ? 
7  O   ? A GLY 56  ? A GLY 56  ? 1_555 NA ? E NA . ? A NA 704 ? 1_555 OG  ? A SER 402 ? A SER 402 ? 1_555 83.7  ? 
8  O   ? A VAL 59  ? A VAL 59  ? 1_555 NA ? E NA . ? A NA 704 ? 1_555 OG  ? A SER 402 ? A SER 402 ? 1_555 82.6  ? 
9  OD1 ? A ASP 401 ? A ASP 401 ? 1_555 NA ? E NA . ? A NA 704 ? 1_555 OG  ? A SER 402 ? A SER 402 ? 1_555 131.8 ? 
10 OD2 ? A ASP 401 ? A ASP 401 ? 1_555 NA ? E NA . ? A NA 704 ? 1_555 OG  ? A SER 402 ? A SER 402 ? 1_555 89.5  ? 
11 O   ? A PHE 58  ? A PHE 58  ? 1_555 NA ? F NA . ? A NA 705 ? 1_555 OD1 ? A ASN 63  ? A ASN 63  ? 1_555 134.7 ? 
12 O   ? A PHE 58  ? A PHE 58  ? 1_555 NA ? F NA . ? A NA 705 ? 1_555 O   ? A SER 301 ? A SER 301 ? 1_555 76.6  ? 
13 OD1 ? A ASN 63  ? A ASN 63  ? 1_555 NA ? F NA . ? A NA 705 ? 1_555 O   ? A SER 301 ? A SER 301 ? 1_555 148.6 ? 
14 O   ? A PHE 58  ? A PHE 58  ? 1_555 NA ? F NA . ? A NA 705 ? 1_555 O09 ? K 3S5 .   ? A 3S5 710 ? 1_555 76.3  ? 
15 OD1 ? A ASN 63  ? A ASN 63  ? 1_555 NA ? F NA . ? A NA 705 ? 1_555 O09 ? K 3S5 .   ? A 3S5 710 ? 1_555 87.4  ? 
16 O   ? A SER 301 ? A SER 301 ? 1_555 NA ? F NA . ? A NA 705 ? 1_555 O09 ? K 3S5 .   ? A 3S5 710 ? 1_555 100.2 ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 NAG B .   ? ASN A 163 ? NAG A 701 ? 1_555 ASN A 163 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
2 NAG C .   ? ASN A 179 ? NAG A 702 ? 1_555 ASN A 179 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
3 NAG D .   ? ASN A 190 ? NAG A 703 ? 1_555 ASN A 190 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
4 CYS A 162 ? CYS A 171 ? CYS A 162 ? 1_555 CYS A 171 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
# 
_pdbx_entry_details.entry_id                   9JD5 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ILE A 116 ? ? -107.01 -60.39  
2 1 SER A 241 ? ? 62.34   177.01  
3 1 ALA A 363 ? ? 55.08   -131.43 
4 1 LEU A 383 ? ? 54.74   70.00   
5 1 LEU A 422 ? ? -93.35  48.40   
6 1 ASN A 533 ? ? 51.11   -122.33 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9JD5 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         REAL 
_em_3d_fitting.ref_protocol      'RIGID BODY FIT' 
# 
_em_3d_reconstruction.entry_id                    9JD5 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  2.58 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               223560 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.5 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'Complex of human Taurine Transporter with taurocyamine' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        9JD5 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'TFS KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      2.7 
_em_imaging.nominal_defocus_min             1500 
_em_imaging.nominal_defocus_max             2000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_sample_support.id               1 
_em_sample_support.film_material    ? 
_em_sample_support.method           ? 
_em_sample_support.grid_material    GOLD 
_em_sample_support.grid_mesh_size   200 
_em_sample_support.grid_type        'Quantifoil R1.2/1.3' 
_em_sample_support.details          ? 
_em_sample_support.specimen_id      1 
_em_sample_support.citation_id      ? 
# 
_em_vitrification.entry_id              9JD5 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              100 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   277.15 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9JD5 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 1   ? A MET 1   
2  1 Y 1 A ALA 2   ? A ALA 2   
3  1 Y 1 A THR 3   ? A THR 3   
4  1 Y 1 A LYS 4   ? A LYS 4   
5  1 Y 1 A GLU 5   ? A GLU 5   
6  1 Y 1 A LYS 6   ? A LYS 6   
7  1 Y 1 A LEU 7   ? A LEU 7   
8  1 Y 1 A GLN 8   ? A GLN 8   
9  1 Y 1 A CYS 9   ? A CYS 9   
10 1 Y 1 A LEU 10  ? A LEU 10  
11 1 Y 1 A LYS 11  ? A LYS 11  
12 1 Y 1 A ASP 12  ? A ASP 12  
13 1 Y 1 A PHE 13  ? A PHE 13  
14 1 Y 1 A HIS 14  ? A HIS 14  
15 1 Y 1 A LYS 15  ? A LYS 15  
16 1 Y 1 A ASP 16  ? A ASP 16  
17 1 Y 1 A ILE 17  ? A ILE 17  
18 1 Y 1 A LEU 18  ? A LEU 18  
19 1 Y 1 A LYS 19  ? A LYS 19  
20 1 Y 1 A PRO 20  ? A PRO 20  
21 1 Y 1 A SER 21  ? A SER 21  
22 1 Y 1 A PRO 22  ? A PRO 22  
23 1 Y 1 A GLY 23  ? A GLY 23  
24 1 Y 1 A LYS 24  ? A LYS 24  
25 1 Y 1 A SER 25  ? A SER 25  
26 1 Y 1 A PRO 26  ? A PRO 26  
27 1 Y 1 A GLY 27  ? A GLY 27  
28 1 Y 1 A THR 28  ? A THR 28  
29 1 Y 1 A ARG 29  ? A ARG 29  
30 1 Y 1 A PRO 30  ? A PRO 30  
31 1 Y 1 A GLU 31  ? A GLU 31  
32 1 Y 1 A ASP 32  ? A ASP 32  
33 1 Y 1 A GLU 33  ? A GLU 33  
34 1 Y 1 A ALA 34  ? A ALA 34  
35 1 Y 1 A GLU 35  ? A GLU 35  
36 1 Y 1 A GLY 36  ? A GLY 36  
37 1 Y 1 A LYS 37  ? A LYS 37  
38 1 Y 1 A PRO 38  ? A PRO 38  
39 1 Y 1 A PRO 39  ? A PRO 39  
40 1 Y 1 A GLN 40  ? A GLN 40  
41 1 Y 1 A THR 568 ? A THR 568 
42 1 Y 1 A GLU 569 ? A GLU 569 
43 1 Y 1 A GLY 570 ? A GLY 570 
44 1 Y 1 A PRO 571 ? A PRO 571 
45 1 Y 1 A PHE 572 ? A PHE 572 
46 1 Y 1 A LEU 573 ? A LEU 573 
47 1 Y 1 A VAL 574 ? A VAL 574 
48 1 Y 1 A ARG 575 ? A ARG 575 
49 1 Y 1 A VAL 576 ? A VAL 576 
50 1 Y 1 A LYS 577 ? A LYS 577 
51 1 Y 1 A TYR 578 ? A TYR 578 
52 1 Y 1 A LEU 579 ? A LEU 579 
53 1 Y 1 A LEU 580 ? A LEU 580 
54 1 Y 1 A THR 581 ? A THR 581 
55 1 Y 1 A PRO 582 ? A PRO 582 
56 1 Y 1 A SER 583 ? A SER 583 
57 1 Y 1 A ARG 584 ? A ARG 584 
58 1 Y 1 A LEU 585 ? A LEU 585 
59 1 Y 1 A GLU 586 ? A GLU 586 
60 1 Y 1 A GLU 587 ? A GLU 587 
61 1 Y 1 A GLU 588 ? A GLU 588 
62 1 Y 1 A LEU 589 ? A LEU 589 
63 1 Y 1 A ARG 590 ? A ARG 590 
64 1 Y 1 A ARG 591 ? A ARG 591 
65 1 Y 1 A ARG 592 ? A ARG 592 
66 1 Y 1 A THR 593 ? A THR 593 
67 1 Y 1 A GLU 594 ? A GLU 594 
68 1 Y 1 A PRO 595 ? A PRO 595 
69 1 Y 1 A GLY 596 ? A GLY 596 
70 1 Y 1 A LEU 597 ? A LEU 597 
71 1 Y 1 A ARG 598 ? A ARG 598 
72 1 Y 1 A SER 599 ? A SER 599 
73 1 Y 1 A ARG 600 ? A ARG 600 
74 1 Y 1 A LEU 601 ? A LEU 601 
75 1 Y 1 A GLU 602 ? A GLU 602 
76 1 Y 1 A VAL 603 ? A VAL 603 
77 1 Y 1 A LEU 604 ? A LEU 604 
78 1 Y 1 A PHE 605 ? A PHE 605 
79 1 Y 1 A GLN 606 ? A GLN 606 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
3S5 N01  N  N N 1   
3S5 C02  C  N N 2   
3S5 N03  N  N N 3   
3S5 N04  N  N N 4   
3S5 C05  C  N N 5   
3S5 C06  C  N N 6   
3S5 S07  S  N N 7   
3S5 O08  O  N N 8   
3S5 O09  O  N N 9   
3S5 O10  O  N N 10  
3S5 H1   H  N N 11  
3S5 H2   H  N N 12  
3S5 H3   H  N N 13  
3S5 H4   H  N N 14  
3S5 H5   H  N N 15  
3S5 H6   H  N N 16  
3S5 H7   H  N N 17  
3S5 H8   H  N N 18  
3S5 H9   H  N N 19  
ALA N    N  N N 20  
ALA CA   C  N S 21  
ALA C    C  N N 22  
ALA O    O  N N 23  
ALA CB   C  N N 24  
ALA OXT  O  N N 25  
ALA H    H  N N 26  
ALA H2   H  N N 27  
ALA HA   H  N N 28  
ALA HB1  H  N N 29  
ALA HB2  H  N N 30  
ALA HB3  H  N N 31  
ALA HXT  H  N N 32  
ARG N    N  N N 33  
ARG CA   C  N S 34  
ARG C    C  N N 35  
ARG O    O  N N 36  
ARG CB   C  N N 37  
ARG CG   C  N N 38  
ARG CD   C  N N 39  
ARG NE   N  N N 40  
ARG CZ   C  N N 41  
ARG NH1  N  N N 42  
ARG NH2  N  N N 43  
ARG OXT  O  N N 44  
ARG H    H  N N 45  
ARG H2   H  N N 46  
ARG HA   H  N N 47  
ARG HB2  H  N N 48  
ARG HB3  H  N N 49  
ARG HG2  H  N N 50  
ARG HG3  H  N N 51  
ARG HD2  H  N N 52  
ARG HD3  H  N N 53  
ARG HE   H  N N 54  
ARG HH11 H  N N 55  
ARG HH12 H  N N 56  
ARG HH21 H  N N 57  
ARG HH22 H  N N 58  
ARG HXT  H  N N 59  
ASN N    N  N N 60  
ASN CA   C  N S 61  
ASN C    C  N N 62  
ASN O    O  N N 63  
ASN CB   C  N N 64  
ASN CG   C  N N 65  
ASN OD1  O  N N 66  
ASN ND2  N  N N 67  
ASN OXT  O  N N 68  
ASN H    H  N N 69  
ASN H2   H  N N 70  
ASN HA   H  N N 71  
ASN HB2  H  N N 72  
ASN HB3  H  N N 73  
ASN HD21 H  N N 74  
ASN HD22 H  N N 75  
ASN HXT  H  N N 76  
ASP N    N  N N 77  
ASP CA   C  N S 78  
ASP C    C  N N 79  
ASP O    O  N N 80  
ASP CB   C  N N 81  
ASP CG   C  N N 82  
ASP OD1  O  N N 83  
ASP OD2  O  N N 84  
ASP OXT  O  N N 85  
ASP H    H  N N 86  
ASP H2   H  N N 87  
ASP HA   H  N N 88  
ASP HB2  H  N N 89  
ASP HB3  H  N N 90  
ASP HD2  H  N N 91  
ASP HXT  H  N N 92  
CL  CL   CL N N 93  
CYS N    N  N N 94  
CYS CA   C  N R 95  
CYS C    C  N N 96  
CYS O    O  N N 97  
CYS CB   C  N N 98  
CYS SG   S  N N 99  
CYS OXT  O  N N 100 
CYS H    H  N N 101 
CYS H2   H  N N 102 
CYS HA   H  N N 103 
CYS HB2  H  N N 104 
CYS HB3  H  N N 105 
CYS HG   H  N N 106 
CYS HXT  H  N N 107 
GLN N    N  N N 108 
GLN CA   C  N S 109 
GLN C    C  N N 110 
GLN O    O  N N 111 
GLN CB   C  N N 112 
GLN CG   C  N N 113 
GLN CD   C  N N 114 
GLN OE1  O  N N 115 
GLN NE2  N  N N 116 
GLN OXT  O  N N 117 
GLN H    H  N N 118 
GLN H2   H  N N 119 
GLN HA   H  N N 120 
GLN HB2  H  N N 121 
GLN HB3  H  N N 122 
GLN HG2  H  N N 123 
GLN HG3  H  N N 124 
GLN HE21 H  N N 125 
GLN HE22 H  N N 126 
GLN HXT  H  N N 127 
GLU N    N  N N 128 
GLU CA   C  N S 129 
GLU C    C  N N 130 
GLU O    O  N N 131 
GLU CB   C  N N 132 
GLU CG   C  N N 133 
GLU CD   C  N N 134 
GLU OE1  O  N N 135 
GLU OE2  O  N N 136 
GLU OXT  O  N N 137 
GLU H    H  N N 138 
GLU H2   H  N N 139 
GLU HA   H  N N 140 
GLU HB2  H  N N 141 
GLU HB3  H  N N 142 
GLU HG2  H  N N 143 
GLU HG3  H  N N 144 
GLU HE2  H  N N 145 
GLU HXT  H  N N 146 
GLY N    N  N N 147 
GLY CA   C  N N 148 
GLY C    C  N N 149 
GLY O    O  N N 150 
GLY OXT  O  N N 151 
GLY H    H  N N 152 
GLY H2   H  N N 153 
GLY HA2  H  N N 154 
GLY HA3  H  N N 155 
GLY HXT  H  N N 156 
HIS N    N  N N 157 
HIS CA   C  N S 158 
HIS C    C  N N 159 
HIS O    O  N N 160 
HIS CB   C  N N 161 
HIS CG   C  Y N 162 
HIS ND1  N  Y N 163 
HIS CD2  C  Y N 164 
HIS CE1  C  Y N 165 
HIS NE2  N  Y N 166 
HIS OXT  O  N N 167 
HIS H    H  N N 168 
HIS H2   H  N N 169 
HIS HA   H  N N 170 
HIS HB2  H  N N 171 
HIS HB3  H  N N 172 
HIS HD1  H  N N 173 
HIS HD2  H  N N 174 
HIS HE1  H  N N 175 
HIS HE2  H  N N 176 
HIS HXT  H  N N 177 
HOH O    O  N N 178 
HOH H1   H  N N 179 
HOH H2   H  N N 180 
ILE N    N  N N 181 
ILE CA   C  N S 182 
ILE C    C  N N 183 
ILE O    O  N N 184 
ILE CB   C  N S 185 
ILE CG1  C  N N 186 
ILE CG2  C  N N 187 
ILE CD1  C  N N 188 
ILE OXT  O  N N 189 
ILE H    H  N N 190 
ILE H2   H  N N 191 
ILE HA   H  N N 192 
ILE HB   H  N N 193 
ILE HG12 H  N N 194 
ILE HG13 H  N N 195 
ILE HG21 H  N N 196 
ILE HG22 H  N N 197 
ILE HG23 H  N N 198 
ILE HD11 H  N N 199 
ILE HD12 H  N N 200 
ILE HD13 H  N N 201 
ILE HXT  H  N N 202 
LEU N    N  N N 203 
LEU CA   C  N S 204 
LEU C    C  N N 205 
LEU O    O  N N 206 
LEU CB   C  N N 207 
LEU CG   C  N N 208 
LEU CD1  C  N N 209 
LEU CD2  C  N N 210 
LEU OXT  O  N N 211 
LEU H    H  N N 212 
LEU H2   H  N N 213 
LEU HA   H  N N 214 
LEU HB2  H  N N 215 
LEU HB3  H  N N 216 
LEU HG   H  N N 217 
LEU HD11 H  N N 218 
LEU HD12 H  N N 219 
LEU HD13 H  N N 220 
LEU HD21 H  N N 221 
LEU HD22 H  N N 222 
LEU HD23 H  N N 223 
LEU HXT  H  N N 224 
LYS N    N  N N 225 
LYS CA   C  N S 226 
LYS C    C  N N 227 
LYS O    O  N N 228 
LYS CB   C  N N 229 
LYS CG   C  N N 230 
LYS CD   C  N N 231 
LYS CE   C  N N 232 
LYS NZ   N  N N 233 
LYS OXT  O  N N 234 
LYS H    H  N N 235 
LYS H2   H  N N 236 
LYS HA   H  N N 237 
LYS HB2  H  N N 238 
LYS HB3  H  N N 239 
LYS HG2  H  N N 240 
LYS HG3  H  N N 241 
LYS HD2  H  N N 242 
LYS HD3  H  N N 243 
LYS HE2  H  N N 244 
LYS HE3  H  N N 245 
LYS HZ1  H  N N 246 
LYS HZ2  H  N N 247 
LYS HZ3  H  N N 248 
LYS HXT  H  N N 249 
MET N    N  N N 250 
MET CA   C  N S 251 
MET C    C  N N 252 
MET O    O  N N 253 
MET CB   C  N N 254 
MET CG   C  N N 255 
MET SD   S  N N 256 
MET CE   C  N N 257 
MET OXT  O  N N 258 
MET H    H  N N 259 
MET H2   H  N N 260 
MET HA   H  N N 261 
MET HB2  H  N N 262 
MET HB3  H  N N 263 
MET HG2  H  N N 264 
MET HG3  H  N N 265 
MET HE1  H  N N 266 
MET HE2  H  N N 267 
MET HE3  H  N N 268 
MET HXT  H  N N 269 
NA  NA   NA N N 270 
NAG C1   C  N R 271 
NAG C2   C  N R 272 
NAG C3   C  N R 273 
NAG C4   C  N S 274 
NAG C5   C  N R 275 
NAG C6   C  N N 276 
NAG C7   C  N N 277 
NAG C8   C  N N 278 
NAG N2   N  N N 279 
NAG O1   O  N N 280 
NAG O3   O  N N 281 
NAG O4   O  N N 282 
NAG O5   O  N N 283 
NAG O6   O  N N 284 
NAG O7   O  N N 285 
NAG H1   H  N N 286 
NAG H2   H  N N 287 
NAG H3   H  N N 288 
NAG H4   H  N N 289 
NAG H5   H  N N 290 
NAG H61  H  N N 291 
NAG H62  H  N N 292 
NAG H81  H  N N 293 
NAG H82  H  N N 294 
NAG H83  H  N N 295 
NAG HN2  H  N N 296 
NAG HO1  H  N N 297 
NAG HO3  H  N N 298 
NAG HO4  H  N N 299 
NAG HO6  H  N N 300 
PHE N    N  N N 301 
PHE CA   C  N S 302 
PHE C    C  N N 303 
PHE O    O  N N 304 
PHE CB   C  N N 305 
PHE CG   C  Y N 306 
PHE CD1  C  Y N 307 
PHE CD2  C  Y N 308 
PHE CE1  C  Y N 309 
PHE CE2  C  Y N 310 
PHE CZ   C  Y N 311 
PHE OXT  O  N N 312 
PHE H    H  N N 313 
PHE H2   H  N N 314 
PHE HA   H  N N 315 
PHE HB2  H  N N 316 
PHE HB3  H  N N 317 
PHE HD1  H  N N 318 
PHE HD2  H  N N 319 
PHE HE1  H  N N 320 
PHE HE2  H  N N 321 
PHE HZ   H  N N 322 
PHE HXT  H  N N 323 
PRO N    N  N N 324 
PRO CA   C  N S 325 
PRO C    C  N N 326 
PRO O    O  N N 327 
PRO CB   C  N N 328 
PRO CG   C  N N 329 
PRO CD   C  N N 330 
PRO OXT  O  N N 331 
PRO H    H  N N 332 
PRO HA   H  N N 333 
PRO HB2  H  N N 334 
PRO HB3  H  N N 335 
PRO HG2  H  N N 336 
PRO HG3  H  N N 337 
PRO HD2  H  N N 338 
PRO HD3  H  N N 339 
PRO HXT  H  N N 340 
SER N    N  N N 341 
SER CA   C  N S 342 
SER C    C  N N 343 
SER O    O  N N 344 
SER CB   C  N N 345 
SER OG   O  N N 346 
SER OXT  O  N N 347 
SER H    H  N N 348 
SER H2   H  N N 349 
SER HA   H  N N 350 
SER HB2  H  N N 351 
SER HB3  H  N N 352 
SER HG   H  N N 353 
SER HXT  H  N N 354 
THR N    N  N N 355 
THR CA   C  N S 356 
THR C    C  N N 357 
THR O    O  N N 358 
THR CB   C  N R 359 
THR OG1  O  N N 360 
THR CG2  C  N N 361 
THR OXT  O  N N 362 
THR H    H  N N 363 
THR H2   H  N N 364 
THR HA   H  N N 365 
THR HB   H  N N 366 
THR HG1  H  N N 367 
THR HG21 H  N N 368 
THR HG22 H  N N 369 
THR HG23 H  N N 370 
THR HXT  H  N N 371 
TRP N    N  N N 372 
TRP CA   C  N S 373 
TRP C    C  N N 374 
TRP O    O  N N 375 
TRP CB   C  N N 376 
TRP CG   C  Y N 377 
TRP CD1  C  Y N 378 
TRP CD2  C  Y N 379 
TRP NE1  N  Y N 380 
TRP CE2  C  Y N 381 
TRP CE3  C  Y N 382 
TRP CZ2  C  Y N 383 
TRP CZ3  C  Y N 384 
TRP CH2  C  Y N 385 
TRP OXT  O  N N 386 
TRP H    H  N N 387 
TRP H2   H  N N 388 
TRP HA   H  N N 389 
TRP HB2  H  N N 390 
TRP HB3  H  N N 391 
TRP HD1  H  N N 392 
TRP HE1  H  N N 393 
TRP HE3  H  N N 394 
TRP HZ2  H  N N 395 
TRP HZ3  H  N N 396 
TRP HH2  H  N N 397 
TRP HXT  H  N N 398 
TYR N    N  N N 399 
TYR CA   C  N S 400 
TYR C    C  N N 401 
TYR O    O  N N 402 
TYR CB   C  N N 403 
TYR CG   C  Y N 404 
TYR CD1  C  Y N 405 
TYR CD2  C  Y N 406 
TYR CE1  C  Y N 407 
TYR CE2  C  Y N 408 
TYR CZ   C  Y N 409 
TYR OH   O  N N 410 
TYR OXT  O  N N 411 
TYR H    H  N N 412 
TYR H2   H  N N 413 
TYR HA   H  N N 414 
TYR HB2  H  N N 415 
TYR HB3  H  N N 416 
TYR HD1  H  N N 417 
TYR HD2  H  N N 418 
TYR HE1  H  N N 419 
TYR HE2  H  N N 420 
TYR HH   H  N N 421 
TYR HXT  H  N N 422 
VAL N    N  N N 423 
VAL CA   C  N S 424 
VAL C    C  N N 425 
VAL O    O  N N 426 
VAL CB   C  N N 427 
VAL CG1  C  N N 428 
VAL CG2  C  N N 429 
VAL OXT  O  N N 430 
VAL H    H  N N 431 
VAL H2   H  N N 432 
VAL HA   H  N N 433 
VAL HB   H  N N 434 
VAL HG11 H  N N 435 
VAL HG12 H  N N 436 
VAL HG13 H  N N 437 
VAL HG21 H  N N 438 
VAL HG22 H  N N 439 
VAL HG23 H  N N 440 
VAL HXT  H  N N 441 
Y01 CAA  C  N N 442 
Y01 CBA  C  N N 443 
Y01 CAB  C  N N 444 
Y01 CAN  C  N N 445 
Y01 CAJ  C  N N 446 
Y01 CAO  C  N N 447 
Y01 CBB  C  N R 448 
Y01 CAC  C  N N 449 
Y01 CBE  C  N R 450 
Y01 CAP  C  N N 451 
Y01 CAQ  C  N N 452 
Y01 CBG  C  N S 453 
Y01 CBI  C  N R 454 
Y01 CAE  C  N N 455 
Y01 CAU  C  N N 456 
Y01 CAS  C  N N 457 
Y01 CBF  C  N S 458 
Y01 CBD  C  N S 459 
Y01 CAK  C  N N 460 
Y01 CAI  C  N N 461 
Y01 CAZ  C  N N 462 
Y01 CAV  C  N N 463 
Y01 CBH  C  N R 464 
Y01 CAD  C  N N 465 
Y01 CAT  C  N N 466 
Y01 CAR  C  N N 467 
Y01 CBC  C  N S 468 
Y01 OAW  O  N N 469 
Y01 CAY  C  N N 470 
Y01 OAG  O  N N 471 
Y01 CAM  C  N N 472 
Y01 CAL  C  N N 473 
Y01 CAX  C  N N 474 
Y01 OAH  O  N N 475 
Y01 OAF  O  N N 476 
Y01 HAA1 H  N N 477 
Y01 HAA2 H  N N 478 
Y01 HAA3 H  N N 479 
Y01 HBA  H  N N 480 
Y01 HAB1 H  N N 481 
Y01 HAB2 H  N N 482 
Y01 HAB3 H  N N 483 
Y01 HAN1 H  N N 484 
Y01 HAN2 H  N N 485 
Y01 HAJ1 H  N N 486 
Y01 HAJ2 H  N N 487 
Y01 HAO1 H  N N 488 
Y01 HAO2 H  N N 489 
Y01 HBB  H  N N 490 
Y01 HAC1 H  N N 491 
Y01 HAC2 H  N N 492 
Y01 HAC3 H  N N 493 
Y01 HBE  H  N N 494 
Y01 HAP1 H  N N 495 
Y01 HAP2 H  N N 496 
Y01 HAQ1 H  N N 497 
Y01 HAQ2 H  N N 498 
Y01 HBG  H  N N 499 
Y01 HBD  H  N N 500 
Y01 HAE1 H  N N 501 
Y01 HAE2 H  N N 502 
Y01 HAE3 H  N N 503 
Y01 HAU1 H  N N 504 
Y01 HAU2 H  N N 505 
Y01 HAS1 H  N N 506 
Y01 HAS2 H  N N 507 
Y01 HBF  H  N N 508 
Y01 HAK1 H  N N 509 
Y01 HAK2 H  N N 510 
Y01 HAI  H  N N 511 
Y01 HAV1 H  N N 512 
Y01 HAV2 H  N N 513 
Y01 HBC  H  N N 514 
Y01 HAD1 H  N N 515 
Y01 HAD2 H  N N 516 
Y01 HAD3 H  N N 517 
Y01 HAT1 H  N N 518 
Y01 HAT2 H  N N 519 
Y01 HAR1 H  N N 520 
Y01 HAR2 H  N N 521 
Y01 HAM1 H  N N 522 
Y01 HAM2 H  N N 523 
Y01 HAL1 H  N N 524 
Y01 HAL2 H  N N 525 
Y01 HAH  H  N N 526 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
3S5 O10 S07  doub N N 1   
3S5 O09 S07  doub N N 2   
3S5 O08 S07  sing N N 3   
3S5 S07 C06  sing N N 4   
3S5 C06 C05  sing N N 5   
3S5 C05 N04  sing N N 6   
3S5 N03 C02  doub N N 7   
3S5 N04 C02  sing N N 8   
3S5 C02 N01  sing N N 9   
3S5 N01 H1   sing N N 10  
3S5 N01 H2   sing N N 11  
3S5 N03 H3   sing N N 12  
3S5 N04 H4   sing N N 13  
3S5 C05 H5   sing N N 14  
3S5 C05 H6   sing N N 15  
3S5 C06 H7   sing N N 16  
3S5 C06 H8   sing N N 17  
3S5 O08 H9   sing N N 18  
ALA N   CA   sing N N 19  
ALA N   H    sing N N 20  
ALA N   H2   sing N N 21  
ALA CA  C    sing N N 22  
ALA CA  CB   sing N N 23  
ALA CA  HA   sing N N 24  
ALA C   O    doub N N 25  
ALA C   OXT  sing N N 26  
ALA CB  HB1  sing N N 27  
ALA CB  HB2  sing N N 28  
ALA CB  HB3  sing N N 29  
ALA OXT HXT  sing N N 30  
ARG N   CA   sing N N 31  
ARG N   H    sing N N 32  
ARG N   H2   sing N N 33  
ARG CA  C    sing N N 34  
ARG CA  CB   sing N N 35  
ARG CA  HA   sing N N 36  
ARG C   O    doub N N 37  
ARG C   OXT  sing N N 38  
ARG CB  CG   sing N N 39  
ARG CB  HB2  sing N N 40  
ARG CB  HB3  sing N N 41  
ARG CG  CD   sing N N 42  
ARG CG  HG2  sing N N 43  
ARG CG  HG3  sing N N 44  
ARG CD  NE   sing N N 45  
ARG CD  HD2  sing N N 46  
ARG CD  HD3  sing N N 47  
ARG NE  CZ   sing N N 48  
ARG NE  HE   sing N N 49  
ARG CZ  NH1  sing N N 50  
ARG CZ  NH2  doub N N 51  
ARG NH1 HH11 sing N N 52  
ARG NH1 HH12 sing N N 53  
ARG NH2 HH21 sing N N 54  
ARG NH2 HH22 sing N N 55  
ARG OXT HXT  sing N N 56  
ASN N   CA   sing N N 57  
ASN N   H    sing N N 58  
ASN N   H2   sing N N 59  
ASN CA  C    sing N N 60  
ASN CA  CB   sing N N 61  
ASN CA  HA   sing N N 62  
ASN C   O    doub N N 63  
ASN C   OXT  sing N N 64  
ASN CB  CG   sing N N 65  
ASN CB  HB2  sing N N 66  
ASN CB  HB3  sing N N 67  
ASN CG  OD1  doub N N 68  
ASN CG  ND2  sing N N 69  
ASN ND2 HD21 sing N N 70  
ASN ND2 HD22 sing N N 71  
ASN OXT HXT  sing N N 72  
ASP N   CA   sing N N 73  
ASP N   H    sing N N 74  
ASP N   H2   sing N N 75  
ASP CA  C    sing N N 76  
ASP CA  CB   sing N N 77  
ASP CA  HA   sing N N 78  
ASP C   O    doub N N 79  
ASP C   OXT  sing N N 80  
ASP CB  CG   sing N N 81  
ASP CB  HB2  sing N N 82  
ASP CB  HB3  sing N N 83  
ASP CG  OD1  doub N N 84  
ASP CG  OD2  sing N N 85  
ASP OD2 HD2  sing N N 86  
ASP OXT HXT  sing N N 87  
CYS N   CA   sing N N 88  
CYS N   H    sing N N 89  
CYS N   H2   sing N N 90  
CYS CA  C    sing N N 91  
CYS CA  CB   sing N N 92  
CYS CA  HA   sing N N 93  
CYS C   O    doub N N 94  
CYS C   OXT  sing N N 95  
CYS CB  SG   sing N N 96  
CYS CB  HB2  sing N N 97  
CYS CB  HB3  sing N N 98  
CYS SG  HG   sing N N 99  
CYS OXT HXT  sing N N 100 
GLN N   CA   sing N N 101 
GLN N   H    sing N N 102 
GLN N   H2   sing N N 103 
GLN CA  C    sing N N 104 
GLN CA  CB   sing N N 105 
GLN CA  HA   sing N N 106 
GLN C   O    doub N N 107 
GLN C   OXT  sing N N 108 
GLN CB  CG   sing N N 109 
GLN CB  HB2  sing N N 110 
GLN CB  HB3  sing N N 111 
GLN CG  CD   sing N N 112 
GLN CG  HG2  sing N N 113 
GLN CG  HG3  sing N N 114 
GLN CD  OE1  doub N N 115 
GLN CD  NE2  sing N N 116 
GLN NE2 HE21 sing N N 117 
GLN NE2 HE22 sing N N 118 
GLN OXT HXT  sing N N 119 
GLU N   CA   sing N N 120 
GLU N   H    sing N N 121 
GLU N   H2   sing N N 122 
GLU CA  C    sing N N 123 
GLU CA  CB   sing N N 124 
GLU CA  HA   sing N N 125 
GLU C   O    doub N N 126 
GLU C   OXT  sing N N 127 
GLU CB  CG   sing N N 128 
GLU CB  HB2  sing N N 129 
GLU CB  HB3  sing N N 130 
GLU CG  CD   sing N N 131 
GLU CG  HG2  sing N N 132 
GLU CG  HG3  sing N N 133 
GLU CD  OE1  doub N N 134 
GLU CD  OE2  sing N N 135 
GLU OE2 HE2  sing N N 136 
GLU OXT HXT  sing N N 137 
GLY N   CA   sing N N 138 
GLY N   H    sing N N 139 
GLY N   H2   sing N N 140 
GLY CA  C    sing N N 141 
GLY CA  HA2  sing N N 142 
GLY CA  HA3  sing N N 143 
GLY C   O    doub N N 144 
GLY C   OXT  sing N N 145 
GLY OXT HXT  sing N N 146 
HIS N   CA   sing N N 147 
HIS N   H    sing N N 148 
HIS N   H2   sing N N 149 
HIS CA  C    sing N N 150 
HIS CA  CB   sing N N 151 
HIS CA  HA   sing N N 152 
HIS C   O    doub N N 153 
HIS C   OXT  sing N N 154 
HIS CB  CG   sing N N 155 
HIS CB  HB2  sing N N 156 
HIS CB  HB3  sing N N 157 
HIS CG  ND1  sing Y N 158 
HIS CG  CD2  doub Y N 159 
HIS ND1 CE1  doub Y N 160 
HIS ND1 HD1  sing N N 161 
HIS CD2 NE2  sing Y N 162 
HIS CD2 HD2  sing N N 163 
HIS CE1 NE2  sing Y N 164 
HIS CE1 HE1  sing N N 165 
HIS NE2 HE2  sing N N 166 
HIS OXT HXT  sing N N 167 
HOH O   H1   sing N N 168 
HOH O   H2   sing N N 169 
ILE N   CA   sing N N 170 
ILE N   H    sing N N 171 
ILE N   H2   sing N N 172 
ILE CA  C    sing N N 173 
ILE CA  CB   sing N N 174 
ILE CA  HA   sing N N 175 
ILE C   O    doub N N 176 
ILE C   OXT  sing N N 177 
ILE CB  CG1  sing N N 178 
ILE CB  CG2  sing N N 179 
ILE CB  HB   sing N N 180 
ILE CG1 CD1  sing N N 181 
ILE CG1 HG12 sing N N 182 
ILE CG1 HG13 sing N N 183 
ILE CG2 HG21 sing N N 184 
ILE CG2 HG22 sing N N 185 
ILE CG2 HG23 sing N N 186 
ILE CD1 HD11 sing N N 187 
ILE CD1 HD12 sing N N 188 
ILE CD1 HD13 sing N N 189 
ILE OXT HXT  sing N N 190 
LEU N   CA   sing N N 191 
LEU N   H    sing N N 192 
LEU N   H2   sing N N 193 
LEU CA  C    sing N N 194 
LEU CA  CB   sing N N 195 
LEU CA  HA   sing N N 196 
LEU C   O    doub N N 197 
LEU C   OXT  sing N N 198 
LEU CB  CG   sing N N 199 
LEU CB  HB2  sing N N 200 
LEU CB  HB3  sing N N 201 
LEU CG  CD1  sing N N 202 
LEU CG  CD2  sing N N 203 
LEU CG  HG   sing N N 204 
LEU CD1 HD11 sing N N 205 
LEU CD1 HD12 sing N N 206 
LEU CD1 HD13 sing N N 207 
LEU CD2 HD21 sing N N 208 
LEU CD2 HD22 sing N N 209 
LEU CD2 HD23 sing N N 210 
LEU OXT HXT  sing N N 211 
LYS N   CA   sing N N 212 
LYS N   H    sing N N 213 
LYS N   H2   sing N N 214 
LYS CA  C    sing N N 215 
LYS CA  CB   sing N N 216 
LYS CA  HA   sing N N 217 
LYS C   O    doub N N 218 
LYS C   OXT  sing N N 219 
LYS CB  CG   sing N N 220 
LYS CB  HB2  sing N N 221 
LYS CB  HB3  sing N N 222 
LYS CG  CD   sing N N 223 
LYS CG  HG2  sing N N 224 
LYS CG  HG3  sing N N 225 
LYS CD  CE   sing N N 226 
LYS CD  HD2  sing N N 227 
LYS CD  HD3  sing N N 228 
LYS CE  NZ   sing N N 229 
LYS CE  HE2  sing N N 230 
LYS CE  HE3  sing N N 231 
LYS NZ  HZ1  sing N N 232 
LYS NZ  HZ2  sing N N 233 
LYS NZ  HZ3  sing N N 234 
LYS OXT HXT  sing N N 235 
MET N   CA   sing N N 236 
MET N   H    sing N N 237 
MET N   H2   sing N N 238 
MET CA  C    sing N N 239 
MET CA  CB   sing N N 240 
MET CA  HA   sing N N 241 
MET C   O    doub N N 242 
MET C   OXT  sing N N 243 
MET CB  CG   sing N N 244 
MET CB  HB2  sing N N 245 
MET CB  HB3  sing N N 246 
MET CG  SD   sing N N 247 
MET CG  HG2  sing N N 248 
MET CG  HG3  sing N N 249 
MET SD  CE   sing N N 250 
MET CE  HE1  sing N N 251 
MET CE  HE2  sing N N 252 
MET CE  HE3  sing N N 253 
MET OXT HXT  sing N N 254 
NAG C1  C2   sing N N 255 
NAG C1  O1   sing N N 256 
NAG C1  O5   sing N N 257 
NAG C1  H1   sing N N 258 
NAG C2  C3   sing N N 259 
NAG C2  N2   sing N N 260 
NAG C2  H2   sing N N 261 
NAG C3  C4   sing N N 262 
NAG C3  O3   sing N N 263 
NAG C3  H3   sing N N 264 
NAG C4  C5   sing N N 265 
NAG C4  O4   sing N N 266 
NAG C4  H4   sing N N 267 
NAG C5  C6   sing N N 268 
NAG C5  O5   sing N N 269 
NAG C5  H5   sing N N 270 
NAG C6  O6   sing N N 271 
NAG C6  H61  sing N N 272 
NAG C6  H62  sing N N 273 
NAG C7  C8   sing N N 274 
NAG C7  N2   sing N N 275 
NAG C7  O7   doub N N 276 
NAG C8  H81  sing N N 277 
NAG C8  H82  sing N N 278 
NAG C8  H83  sing N N 279 
NAG N2  HN2  sing N N 280 
NAG O1  HO1  sing N N 281 
NAG O3  HO3  sing N N 282 
NAG O4  HO4  sing N N 283 
NAG O6  HO6  sing N N 284 
PHE N   CA   sing N N 285 
PHE N   H    sing N N 286 
PHE N   H2   sing N N 287 
PHE CA  C    sing N N 288 
PHE CA  CB   sing N N 289 
PHE CA  HA   sing N N 290 
PHE C   O    doub N N 291 
PHE C   OXT  sing N N 292 
PHE CB  CG   sing N N 293 
PHE CB  HB2  sing N N 294 
PHE CB  HB3  sing N N 295 
PHE CG  CD1  doub Y N 296 
PHE CG  CD2  sing Y N 297 
PHE CD1 CE1  sing Y N 298 
PHE CD1 HD1  sing N N 299 
PHE CD2 CE2  doub Y N 300 
PHE CD2 HD2  sing N N 301 
PHE CE1 CZ   doub Y N 302 
PHE CE1 HE1  sing N N 303 
PHE CE2 CZ   sing Y N 304 
PHE CE2 HE2  sing N N 305 
PHE CZ  HZ   sing N N 306 
PHE OXT HXT  sing N N 307 
PRO N   CA   sing N N 308 
PRO N   CD   sing N N 309 
PRO N   H    sing N N 310 
PRO CA  C    sing N N 311 
PRO CA  CB   sing N N 312 
PRO CA  HA   sing N N 313 
PRO C   O    doub N N 314 
PRO C   OXT  sing N N 315 
PRO CB  CG   sing N N 316 
PRO CB  HB2  sing N N 317 
PRO CB  HB3  sing N N 318 
PRO CG  CD   sing N N 319 
PRO CG  HG2  sing N N 320 
PRO CG  HG3  sing N N 321 
PRO CD  HD2  sing N N 322 
PRO CD  HD3  sing N N 323 
PRO OXT HXT  sing N N 324 
SER N   CA   sing N N 325 
SER N   H    sing N N 326 
SER N   H2   sing N N 327 
SER CA  C    sing N N 328 
SER CA  CB   sing N N 329 
SER CA  HA   sing N N 330 
SER C   O    doub N N 331 
SER C   OXT  sing N N 332 
SER CB  OG   sing N N 333 
SER CB  HB2  sing N N 334 
SER CB  HB3  sing N N 335 
SER OG  HG   sing N N 336 
SER OXT HXT  sing N N 337 
THR N   CA   sing N N 338 
THR N   H    sing N N 339 
THR N   H2   sing N N 340 
THR CA  C    sing N N 341 
THR CA  CB   sing N N 342 
THR CA  HA   sing N N 343 
THR C   O    doub N N 344 
THR C   OXT  sing N N 345 
THR CB  OG1  sing N N 346 
THR CB  CG2  sing N N 347 
THR CB  HB   sing N N 348 
THR OG1 HG1  sing N N 349 
THR CG2 HG21 sing N N 350 
THR CG2 HG22 sing N N 351 
THR CG2 HG23 sing N N 352 
THR OXT HXT  sing N N 353 
TRP N   CA   sing N N 354 
TRP N   H    sing N N 355 
TRP N   H2   sing N N 356 
TRP CA  C    sing N N 357 
TRP CA  CB   sing N N 358 
TRP CA  HA   sing N N 359 
TRP C   O    doub N N 360 
TRP C   OXT  sing N N 361 
TRP CB  CG   sing N N 362 
TRP CB  HB2  sing N N 363 
TRP CB  HB3  sing N N 364 
TRP CG  CD1  doub Y N 365 
TRP CG  CD2  sing Y N 366 
TRP CD1 NE1  sing Y N 367 
TRP CD1 HD1  sing N N 368 
TRP CD2 CE2  doub Y N 369 
TRP CD2 CE3  sing Y N 370 
TRP NE1 CE2  sing Y N 371 
TRP NE1 HE1  sing N N 372 
TRP CE2 CZ2  sing Y N 373 
TRP CE3 CZ3  doub Y N 374 
TRP CE3 HE3  sing N N 375 
TRP CZ2 CH2  doub Y N 376 
TRP CZ2 HZ2  sing N N 377 
TRP CZ3 CH2  sing Y N 378 
TRP CZ3 HZ3  sing N N 379 
TRP CH2 HH2  sing N N 380 
TRP OXT HXT  sing N N 381 
TYR N   CA   sing N N 382 
TYR N   H    sing N N 383 
TYR N   H2   sing N N 384 
TYR CA  C    sing N N 385 
TYR CA  CB   sing N N 386 
TYR CA  HA   sing N N 387 
TYR C   O    doub N N 388 
TYR C   OXT  sing N N 389 
TYR CB  CG   sing N N 390 
TYR CB  HB2  sing N N 391 
TYR CB  HB3  sing N N 392 
TYR CG  CD1  doub Y N 393 
TYR CG  CD2  sing Y N 394 
TYR CD1 CE1  sing Y N 395 
TYR CD1 HD1  sing N N 396 
TYR CD2 CE2  doub Y N 397 
TYR CD2 HD2  sing N N 398 
TYR CE1 CZ   doub Y N 399 
TYR CE1 HE1  sing N N 400 
TYR CE2 CZ   sing Y N 401 
TYR CE2 HE2  sing N N 402 
TYR CZ  OH   sing N N 403 
TYR OH  HH   sing N N 404 
TYR OXT HXT  sing N N 405 
VAL N   CA   sing N N 406 
VAL N   H    sing N N 407 
VAL N   H2   sing N N 408 
VAL CA  C    sing N N 409 
VAL CA  CB   sing N N 410 
VAL CA  HA   sing N N 411 
VAL C   O    doub N N 412 
VAL C   OXT  sing N N 413 
VAL CB  CG1  sing N N 414 
VAL CB  CG2  sing N N 415 
VAL CB  HB   sing N N 416 
VAL CG1 HG11 sing N N 417 
VAL CG1 HG12 sing N N 418 
VAL CG1 HG13 sing N N 419 
VAL CG2 HG21 sing N N 420 
VAL CG2 HG22 sing N N 421 
VAL CG2 HG23 sing N N 422 
VAL OXT HXT  sing N N 423 
Y01 CAA CBA  sing N N 424 
Y01 CBA CAB  sing N N 425 
Y01 CBA CAN  sing N N 426 
Y01 CAN CAJ  sing N N 427 
Y01 CAJ CAO  sing N N 428 
Y01 CAO CBB  sing N N 429 
Y01 CBB CAC  sing N N 430 
Y01 CBB CBE  sing N N 431 
Y01 CBE CAP  sing N N 432 
Y01 CBE CBI  sing N N 433 
Y01 CAP CAQ  sing N N 434 
Y01 CAQ CBG  sing N N 435 
Y01 CBG CBI  sing N N 436 
Y01 CBG CBD  sing N N 437 
Y01 CBI CAE  sing N N 438 
Y01 CBI CAU  sing N N 439 
Y01 CAU CAS  sing N N 440 
Y01 CAS CBF  sing N N 441 
Y01 CBF CBD  sing N N 442 
Y01 CBF CBH  sing N N 443 
Y01 CBD CAK  sing N N 444 
Y01 CAK CAI  sing N N 445 
Y01 CAI CAZ  doub N N 446 
Y01 CAZ CAV  sing N N 447 
Y01 CAZ CBH  sing N N 448 
Y01 CAV CBC  sing N N 449 
Y01 CBH CAD  sing N N 450 
Y01 CBH CAT  sing N N 451 
Y01 CAT CAR  sing N N 452 
Y01 CAR CBC  sing N N 453 
Y01 CBC OAW  sing N N 454 
Y01 OAW CAY  sing N N 455 
Y01 CAY OAG  doub N N 456 
Y01 CAY CAM  sing N N 457 
Y01 CAM CAL  sing N N 458 
Y01 CAL CAX  sing N N 459 
Y01 CAX OAH  sing N N 460 
Y01 CAX OAF  doub N N 461 
Y01 CAA HAA1 sing N N 462 
Y01 CAA HAA2 sing N N 463 
Y01 CAA HAA3 sing N N 464 
Y01 CBA HBA  sing N N 465 
Y01 CAB HAB1 sing N N 466 
Y01 CAB HAB2 sing N N 467 
Y01 CAB HAB3 sing N N 468 
Y01 CAN HAN1 sing N N 469 
Y01 CAN HAN2 sing N N 470 
Y01 CAJ HAJ1 sing N N 471 
Y01 CAJ HAJ2 sing N N 472 
Y01 CAO HAO1 sing N N 473 
Y01 CAO HAO2 sing N N 474 
Y01 CBB HBB  sing N N 475 
Y01 CAC HAC1 sing N N 476 
Y01 CAC HAC2 sing N N 477 
Y01 CAC HAC3 sing N N 478 
Y01 CBE HBE  sing N N 479 
Y01 CAP HAP1 sing N N 480 
Y01 CAP HAP2 sing N N 481 
Y01 CAQ HAQ1 sing N N 482 
Y01 CAQ HAQ2 sing N N 483 
Y01 CBG HBG  sing N N 484 
Y01 CBD HBD  sing N N 485 
Y01 CAE HAE1 sing N N 486 
Y01 CAE HAE2 sing N N 487 
Y01 CAE HAE3 sing N N 488 
Y01 CAU HAU1 sing N N 489 
Y01 CAU HAU2 sing N N 490 
Y01 CAS HAS1 sing N N 491 
Y01 CAS HAS2 sing N N 492 
Y01 CBF HBF  sing N N 493 
Y01 CAK HAK1 sing N N 494 
Y01 CAK HAK2 sing N N 495 
Y01 CAI HAI  sing N N 496 
Y01 CAV HAV1 sing N N 497 
Y01 CAV HAV2 sing N N 498 
Y01 CBC HBC  sing N N 499 
Y01 CAD HAD1 sing N N 500 
Y01 CAD HAD2 sing N N 501 
Y01 CAD HAD3 sing N N 502 
Y01 CAT HAT1 sing N N 503 
Y01 CAT HAT2 sing N N 504 
Y01 CAR HAR1 sing N N 505 
Y01 CAR HAR2 sing N N 506 
Y01 CAM HAM1 sing N N 507 
Y01 CAM HAM2 sing N N 508 
Y01 CAL HAL1 sing N N 509 
Y01 CAL HAL2 sing N N 510 
Y01 OAH HAH  sing N N 511 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-08-30 
_em_admin.deposition_site    PDBJ 
_em_admin.entry_id           9JD5 
_em_admin.last_update        2025-05-07 
_em_admin.map_release_date   2025-03-19 
_em_admin.title              
'Cryo-EM structure of human TauT in presence of Taurocyamine, determined in an inward-facing occluded conformation' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          9606 
_em_entity_assembly_recombinant.organism             'Homo sapiens' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         50 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'FEI FALCON IV (4k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'MODEL REFINEMENT'              ? 1  ? ? ? PHENIX 1.19.2_4158: 
'IMAGE ACQUISITION'             ? 2  1 ? 1 ?      ?            
'PARTICLE SELECTION'            ? 3  1 1 1 ?      ?            
'VOLUME SELECTION'              ? 4  1 1 1 ?      ?            
CLASSIFICATION                  ? 5  1 1 1 ?      ?            
MASKING                         ? 6  1 1 1 ?      ?            
RECONSTRUCTION                  ? 7  1 1 1 ?      ?            
'INITIAL EULER ASSIGNMENT'      ? 8  1 1 1 ?      ?            
'FINAL EULER ASSIGNMENT'        ? 9  1 1 1 ?      ?            
'CTF CORRECTION'                ? 10 1 1 1 ?      ?            
'LAYERLINE INDEXING'            ? 11 1 1 1 ?      ?            
'DIFFRACTION INDEXING'          ? 12 1 1 1 ?      ?            
'MODEL FITTING'                 ? 13 1 1 1 ?      ?            
'SERIES ALIGNMENT'              ? 14 1 1 1 ?      ?            
'MOLECULAR REPLACEMENT'         ? 15 1 1 1 ?      ?            
'LATTICE DISTORTION CORRECTION' ? 16 1 1 1 ?      ?            
'SYMMETRY DETERMINATION'        ? 17 1 1 1 ?      ?            
'CRYSTALLOGRAPHY MERGING'       ? 18 1 1 1 ?      ?            
OTHER                           ? 19 1 1 1 ?      ?            
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           32171194 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    9JD5 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
CL 
N  
NA 
O  
S  
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . ARG A 1 41  ? 124.355 111.520 88.331  1.00 117.58 ? 41  ARG A N   1 
ATOM   2    C  CA  . ARG A 1 41  ? 125.716 111.610 87.819  1.00 117.58 ? 41  ARG A CA  1 
ATOM   3    C  C   . ARG A 1 41  ? 126.667 110.738 88.632  1.00 117.58 ? 41  ARG A C   1 
ATOM   4    O  O   . ARG A 1 41  ? 127.823 110.546 88.255  1.00 117.58 ? 41  ARG A O   1 
ATOM   5    C  CB  . ARG A 1 41  ? 126.195 113.063 87.824  1.00 117.58 ? 41  ARG A CB  1 
ATOM   6    C  CG  . ARG A 1 41  ? 127.279 113.364 86.800  1.00 117.58 ? 41  ARG A CG  1 
ATOM   7    C  CD  . ARG A 1 41  ? 127.505 114.860 86.652  1.00 117.58 ? 41  ARG A CD  1 
ATOM   8    N  NE  . ARG A 1 41  ? 128.155 115.441 87.821  1.00 117.58 ? 41  ARG A NE  1 
ATOM   9    C  CZ  . ARG A 1 41  ? 128.311 116.743 88.020  1.00 117.58 ? 41  ARG A CZ  1 
ATOM   10   N  NH1 . ARG A 1 41  ? 127.873 117.633 87.145  1.00 117.58 ? 41  ARG A NH1 1 
ATOM   11   N  NH2 . ARG A 1 41  ? 128.922 117.162 89.125  1.00 117.58 ? 41  ARG A NH2 1 
ATOM   12   N  N   . GLU A 1 42  ? 126.174 110.205 89.747  1.00 107.62 ? 42  GLU A N   1 
ATOM   13   C  CA  . GLU A 1 42  ? 126.961 109.352 90.623  1.00 107.62 ? 42  GLU A CA  1 
ATOM   14   C  C   . GLU A 1 42  ? 126.329 107.970 90.710  1.00 107.62 ? 42  GLU A C   1 
ATOM   15   O  O   . GLU A 1 42  ? 125.113 107.814 90.577  1.00 107.62 ? 42  GLU A O   1 
ATOM   16   C  CB  . GLU A 1 42  ? 127.090 109.956 92.029  1.00 107.62 ? 42  GLU A CB  1 
ATOM   17   C  CG  . GLU A 1 42  ? 125.796 109.978 92.832  1.00 107.62 ? 42  GLU A CG  1 
ATOM   18   C  CD  . GLU A 1 42  ? 124.936 111.192 92.534  1.00 107.62 ? 42  GLU A CD  1 
ATOM   19   O  OE1 . GLU A 1 42  ? 125.178 111.862 91.508  1.00 107.62 ? 42  GLU A OE1 1 
ATOM   20   O  OE2 . GLU A 1 42  ? 124.014 111.476 93.326  1.00 107.62 ? 42  GLU A OE2 1 
ATOM   21   N  N   . LYS A 1 43  ? 127.172 106.968 90.922  1.00 98.90  ? 43  LYS A N   1 
ATOM   22   C  CA  . LYS A 1 43  ? 126.751 105.584 91.071  1.00 98.90  ? 43  LYS A CA  1 
ATOM   23   C  C   . LYS A 1 43  ? 126.976 105.136 92.511  1.00 98.90  ? 43  LYS A C   1 
ATOM   24   O  O   . LYS A 1 43  ? 127.538 105.863 93.334  1.00 98.90  ? 43  LYS A O   1 
ATOM   25   C  CB  . LYS A 1 43  ? 127.507 104.684 90.091  1.00 98.90  ? 43  LYS A CB  1 
ATOM   26   C  CG  . LYS A 1 43  ? 127.613 105.243 88.681  1.00 98.90  ? 43  LYS A CG  1 
ATOM   27   C  CD  . LYS A 1 43  ? 126.498 104.724 87.787  1.00 98.90  ? 43  LYS A CD  1 
ATOM   28   C  CE  . LYS A 1 43  ? 126.139 105.735 86.707  1.00 98.90  ? 43  LYS A CE  1 
ATOM   29   N  NZ  . LYS A 1 43  ? 124.946 105.316 85.921  1.00 98.90  ? 43  LYS A NZ  1 
ATOM   30   N  N   . TRP A 1 44  ? 126.523 103.924 92.816  1.00 97.09  ? 44  TRP A N   1 
ATOM   31   C  CA  . TRP A 1 44  ? 126.772 103.357 94.133  1.00 97.09  ? 44  TRP A CA  1 
ATOM   32   C  C   . TRP A 1 44  ? 128.259 103.083 94.313  1.00 97.09  ? 44  TRP A C   1 
ATOM   33   O  O   . TRP A 1 44  ? 128.932 102.595 93.401  1.00 97.09  ? 44  TRP A O   1 
ATOM   34   C  CB  . TRP A 1 44  ? 125.978 102.065 94.326  1.00 97.09  ? 44  TRP A CB  1 
ATOM   35   C  CG  . TRP A 1 44  ? 124.497 102.217 94.169  1.00 97.09  ? 44  TRP A CG  1 
ATOM   36   C  CD1 . TRP A 1 44  ? 123.737 101.799 93.116  1.00 97.09  ? 44  TRP A CD1 1 
ATOM   37   C  CD2 . TRP A 1 44  ? 123.592 102.825 95.099  1.00 97.09  ? 44  TRP A CD2 1 
ATOM   38   N  NE1 . TRP A 1 44  ? 122.417 102.109 93.331  1.00 97.09  ? 44  TRP A NE1 1 
ATOM   39   C  CE2 . TRP A 1 44  ? 122.302 102.741 94.541  1.00 97.09  ? 44  TRP A CE2 1 
ATOM   40   C  CE3 . TRP A 1 44  ? 123.749 103.434 96.347  1.00 97.09  ? 44  TRP A CE3 1 
ATOM   41   C  CZ2 . TRP A 1 44  ? 121.176 103.242 95.188  1.00 97.09  ? 44  TRP A CZ2 1 
ATOM   42   C  CZ3 . TRP A 1 44  ? 122.631 103.931 96.987  1.00 97.09  ? 44  TRP A CZ3 1 
ATOM   43   C  CH2 . TRP A 1 44  ? 121.361 103.832 96.407  1.00 97.09  ? 44  TRP A CH2 1 
ATOM   44   N  N   . SER A 1 45  ? 128.774 103.410 95.500  1.00 103.32 ? 45  SER A N   1 
ATOM   45   C  CA  . SER A 1 45  ? 130.167 103.100 95.803  1.00 103.32 ? 45  SER A CA  1 
ATOM   46   C  C   . SER A 1 45  ? 130.406 101.596 95.834  1.00 103.32 ? 45  SER A C   1 
ATOM   47   O  O   . SER A 1 45  ? 131.446 101.124 95.361  1.00 103.32 ? 45  SER A O   1 
ATOM   48   C  CB  . SER A 1 45  ? 130.570 103.736 97.132  1.00 103.32 ? 45  SER A CB  1 
ATOM   49   O  OG  . SER A 1 45  ? 130.495 105.149 97.062  1.00 103.32 ? 45  SER A OG  1 
ATOM   50   N  N   . SER A 1 46  ? 129.462 100.837 96.381  1.00 103.18 ? 46  SER A N   1 
ATOM   51   C  CA  . SER A 1 46  ? 129.536 99.384  96.388  1.00 103.18 ? 46  SER A CA  1 
ATOM   52   C  C   . SER A 1 46  ? 128.138 98.834  96.147  1.00 103.18 ? 46  SER A C   1 
ATOM   53   O  O   . SER A 1 46  ? 127.142 99.558  96.219  1.00 103.18 ? 46  SER A O   1 
ATOM   54   C  CB  . SER A 1 46  ? 130.121 98.855  97.702  1.00 103.18 ? 46  SER A CB  1 
ATOM   55   O  OG  . SER A 1 46  ? 129.297 99.194  98.802  1.00 103.18 ? 46  SER A OG  1 
ATOM   56   N  N   . LYS A 1 47  ? 128.073 97.537  95.851  1.00 101.85 ? 47  LYS A N   1 
ATOM   57   C  CA  . LYS A 1 47  ? 126.797 96.904  95.547  1.00 101.85 ? 47  LYS A CA  1 
ATOM   58   C  C   . LYS A 1 47  ? 125.965 96.607  96.788  1.00 101.85 ? 47  LYS A C   1 
ATOM   59   O  O   . LYS A 1 47  ? 124.773 96.315  96.655  1.00 101.85 ? 47  LYS A O   1 
ATOM   60   C  CB  . LYS A 1 47  ? 127.029 95.614  94.756  1.00 101.85 ? 47  LYS A CB  1 
ATOM   61   C  CG  . LYS A 1 47  ? 127.506 95.857  93.332  1.00 101.85 ? 47  LYS A CG  1 
ATOM   62   C  CD  . LYS A 1 47  ? 128.281 94.671  92.784  1.00 101.85 ? 47  LYS A CD  1 
ATOM   63   C  CE  . LYS A 1 47  ? 128.690 94.908  91.339  1.00 101.85 ? 47  LYS A CE  1 
ATOM   64   N  NZ  . LYS A 1 47  ? 129.242 93.681  90.703  1.00 101.85 ? 47  LYS A NZ  1 
ATOM   65   N  N   . ILE A 1 48  ? 126.552 96.675  97.985  1.00 99.68  ? 48  ILE A N   1 
ATOM   66   C  CA  . ILE A 1 48  ? 125.764 96.456  99.193  1.00 99.68  ? 48  ILE A CA  1 
ATOM   67   C  C   . ILE A 1 48  ? 124.886 97.665  99.488  1.00 99.68  ? 48  ILE A C   1 
ATOM   68   O  O   . ILE A 1 48  ? 123.817 97.531  100.101 1.00 99.68  ? 48  ILE A O   1 
ATOM   69   C  CB  . ILE A 1 48  ? 126.684 96.111  100.381 1.00 99.68  ? 48  ILE A CB  1 
ATOM   70   C  CG1 . ILE A 1 48  ? 125.861 95.590  101.560 1.00 99.68  ? 48  ILE A CG1 1 
ATOM   71   C  CG2 . ILE A 1 48  ? 127.517 97.312  100.795 1.00 99.68  ? 48  ILE A CG2 1 
ATOM   72   C  CD1 . ILE A 1 48  ? 125.178 94.272  101.286 1.00 99.68  ? 48  ILE A CD1 1 
ATOM   73   N  N   . ASP A 1 49  ? 125.308 98.856  99.057  1.00 100.36 ? 49  ASP A N   1 
ATOM   74   C  CA  . ASP A 1 49  ? 124.506 100.053 99.285  1.00 100.36 ? 49  ASP A CA  1 
ATOM   75   C  C   . ASP A 1 49  ? 123.168 99.964  98.563  1.00 100.36 ? 49  ASP A C   1 
ATOM   76   O  O   . ASP A 1 49  ? 122.128 100.323 99.126  1.00 100.36 ? 49  ASP A O   1 
ATOM   77   C  CB  . ASP A 1 49  ? 125.275 101.296 98.837  1.00 100.36 ? 49  ASP A CB  1 
ATOM   78   C  CG  . ASP A 1 49  ? 126.493 101.570 99.697  1.00 100.36 ? 49  ASP A CG  1 
ATOM   79   O  OD1 . ASP A 1 49  ? 127.005 100.622 100.327 1.00 100.36 ? 49  ASP A OD1 1 
ATOM   80   O  OD2 . ASP A 1 49  ? 126.937 102.736 99.746  1.00 100.36 ? 49  ASP A OD2 1 
ATOM   81   N  N   . PHE A 1 50  ? 123.176 99.488  97.316  1.00 94.25  ? 50  PHE A N   1 
ATOM   82   C  CA  . PHE A 1 50  ? 121.935 99.347  96.560  1.00 94.25  ? 50  PHE A CA  1 
ATOM   83   C  C   . PHE A 1 50  ? 120.995 98.355  97.231  1.00 94.25  ? 50  PHE A C   1 
ATOM   84   O  O   . PHE A 1 50  ? 119.794 98.613  97.370  1.00 94.25  ? 50  PHE A O   1 
ATOM   85   C  CB  . PHE A 1 50  ? 122.253 98.915  95.126  1.00 94.25  ? 50  PHE A CB  1 
ATOM   86   C  CG  . PHE A 1 50  ? 121.111 98.238  94.418  1.00 94.25  ? 50  PHE A CG  1 
ATOM   87   C  CD1 . PHE A 1 50  ? 120.144 98.982  93.766  1.00 94.25  ? 50  PHE A CD1 1 
ATOM   88   C  CD2 . PHE A 1 50  ? 121.019 96.855  94.382  1.00 94.25  ? 50  PHE A CD2 1 
ATOM   89   C  CE1 . PHE A 1 50  ? 119.102 98.362  93.103  1.00 94.25  ? 50  PHE A CE1 1 
ATOM   90   C  CE2 . PHE A 1 50  ? 119.976 96.232  93.724  1.00 94.25  ? 50  PHE A CE2 1 
ATOM   91   C  CZ  . PHE A 1 50  ? 119.018 96.986  93.084  1.00 94.25  ? 50  PHE A CZ  1 
ATOM   92   N  N   . VAL A 1 51  ? 121.531 97.211  97.660  1.00 91.33  ? 51  VAL A N   1 
ATOM   93   C  CA  . VAL A 1 51  ? 120.706 96.199  98.311  1.00 91.33  ? 51  VAL A CA  1 
ATOM   94   C  C   . VAL A 1 51  ? 120.097 96.751  99.591  1.00 91.33  ? 51  VAL A C   1 
ATOM   95   O  O   . VAL A 1 51  ? 118.900 96.578  99.850  1.00 91.33  ? 51  VAL A O   1 
ATOM   96   C  CB  . VAL A 1 51  ? 121.531 94.926  98.576  1.00 91.33  ? 51  VAL A CB  1 
ATOM   97   C  CG1 . VAL A 1 51  ? 120.791 93.997  99.524  1.00 91.33  ? 51  VAL A CG1 1 
ATOM   98   C  CG2 . VAL A 1 51  ? 121.841 94.217  97.267  1.00 91.33  ? 51  VAL A CG2 1 
ATOM   99   N  N   . LEU A 1 52  ? 120.903 97.436  100.407 1.00 90.58  ? 52  LEU A N   1 
ATOM   100  C  CA  . LEU A 1 52  ? 120.386 97.993  101.653 1.00 90.58  ? 52  LEU A CA  1 
ATOM   101  C  C   . LEU A 1 52  ? 119.344 99.078  101.402 1.00 90.58  ? 52  LEU A C   1 
ATOM   102  O  O   . LEU A 1 52  ? 118.328 99.132  102.105 1.00 90.58  ? 52  LEU A O   1 
ATOM   103  C  CB  . LEU A 1 52  ? 121.537 98.538  102.498 1.00 90.58  ? 52  LEU A CB  1 
ATOM   104  C  CG  . LEU A 1 52  ? 122.239 97.507  103.386 1.00 90.58  ? 52  LEU A CG  1 
ATOM   105  C  CD1 . LEU A 1 52  ? 123.265 98.174  104.286 1.00 90.58  ? 52  LEU A CD1 1 
ATOM   106  C  CD2 . LEU A 1 52  ? 121.227 96.733  104.211 1.00 90.58  ? 52  LEU A CD2 1 
ATOM   107  N  N   . SER A 1 53  ? 119.570 99.943  100.410 1.00 88.23  ? 53  SER A N   1 
ATOM   108  C  CA  . SER A 1 53  ? 118.601 100.993 100.112 1.00 88.23  ? 53  SER A CA  1 
ATOM   109  C  C   . SER A 1 53  ? 117.277 100.409 99.638  1.00 88.23  ? 53  SER A C   1 
ATOM   110  O  O   . SER A 1 53  ? 116.208 100.856 100.067 1.00 88.23  ? 53  SER A O   1 
ATOM   111  C  CB  . SER A 1 53  ? 119.168 101.950 99.066  1.00 88.23  ? 53  SER A CB  1 
ATOM   112  O  OG  . SER A 1 53  ? 120.118 102.826 99.643  1.00 88.23  ? 53  SER A OG  1 
ATOM   113  N  N   . VAL A 1 54  ? 117.324 99.408  98.755  1.00 84.61  ? 54  VAL A N   1 
ATOM   114  C  CA  . VAL A 1 54  ? 116.081 98.810  98.277  1.00 84.61  ? 54  VAL A CA  1 
ATOM   115  C  C   . VAL A 1 54  ? 115.387 98.042  99.397  1.00 84.61  ? 54  VAL A C   1 
ATOM   116  O  O   . VAL A 1 54  ? 114.154 98.046  99.485  1.00 84.61  ? 54  VAL A O   1 
ATOM   117  C  CB  . VAL A 1 54  ? 116.346 97.925  97.045  1.00 84.61  ? 54  VAL A CB  1 
ATOM   118  C  CG1 . VAL A 1 54  ? 115.053 97.382  96.501  1.00 84.61  ? 54  VAL A CG1 1 
ATOM   119  C  CG2 . VAL A 1 54  ? 117.035 98.730  95.964  1.00 84.61  ? 54  VAL A CG2 1 
ATOM   120  N  N   . ALA A 1 55  ? 116.151 97.386  100.274 1.00 81.03  ? 55  ALA A N   1 
ATOM   121  C  CA  . ALA A 1 55  ? 115.547 96.699  101.409 1.00 81.03  ? 55  ALA A CA  1 
ATOM   122  C  C   . ALA A 1 55  ? 114.862 97.672  102.359 1.00 81.03  ? 55  ALA A C   1 
ATOM   123  O  O   . ALA A 1 55  ? 113.795 97.361  102.898 1.00 81.03  ? 55  ALA A O   1 
ATOM   124  C  CB  . ALA A 1 55  ? 116.603 95.887  102.157 1.00 81.03  ? 55  ALA A CB  1 
ATOM   125  N  N   . GLY A 1 56  ? 115.460 98.840  102.589 1.00 79.93  ? 56  GLY A N   1 
ATOM   126  C  CA  . GLY A 1 56  ? 114.831 99.849  103.416 1.00 79.93  ? 56  GLY A CA  1 
ATOM   127  C  C   . GLY A 1 56  ? 113.786 100.692 102.727 1.00 79.93  ? 56  GLY A C   1 
ATOM   128  O  O   . GLY A 1 56  ? 113.092 101.467 103.390 1.00 79.93  ? 56  GLY A O   1 
ATOM   129  N  N   . GLY A 1 57  ? 113.651 100.562 101.407 1.00 80.25  ? 57  GLY A N   1 
ATOM   130  C  CA  . GLY A 1 57  ? 112.698 101.391 100.686 1.00 80.25  ? 57  GLY A CA  1 
ATOM   131  C  C   . GLY A 1 57  ? 111.279 100.854 100.718 1.00 80.25  ? 57  GLY A C   1 
ATOM   132  O  O   . GLY A 1 57  ? 110.329 101.612 100.925 1.00 80.25  ? 57  GLY A O   1 
ATOM   133  N  N   . PHE A 1 58  ? 111.107 99.546  100.507 1.00 75.67  ? 58  PHE A N   1 
ATOM   134  C  CA  . PHE A 1 58  ? 109.772 98.968  100.402 1.00 75.67  ? 58  PHE A CA  1 
ATOM   135  C  C   . PHE A 1 58  ? 109.384 98.095  101.590 1.00 75.67  ? 58  PHE A C   1 
ATOM   136  O  O   . PHE A 1 58  ? 108.352 97.419  101.528 1.00 75.67  ? 58  PHE A O   1 
ATOM   137  C  CB  . PHE A 1 58  ? 109.614 98.172  99.097  1.00 75.67  ? 58  PHE A CB  1 
ATOM   138  C  CG  . PHE A 1 58  ? 110.544 96.987  98.961  1.00 75.67  ? 58  PHE A CG  1 
ATOM   139  C  CD1 . PHE A 1 58  ? 110.375 95.849  99.729  1.00 75.67  ? 58  PHE A CD1 1 
ATOM   140  C  CD2 . PHE A 1 58  ? 111.540 96.985  98.008  1.00 75.67  ? 58  PHE A CD2 1 
ATOM   141  C  CE1 . PHE A 1 58  ? 111.215 94.767  99.588  1.00 75.67  ? 58  PHE A CE1 1 
ATOM   142  C  CE2 . PHE A 1 58  ? 112.372 95.898  97.861  1.00 75.67  ? 58  PHE A CE2 1 
ATOM   143  C  CZ  . PHE A 1 58  ? 112.209 94.791  98.652  1.00 75.67  ? 58  PHE A CZ  1 
ATOM   144  N  N   . VAL A 1 59  ? 110.168 98.079  102.662 1.00 73.58  ? 59  VAL A N   1 
ATOM   145  C  CA  . VAL A 1 59  ? 109.815 97.356  103.879 1.00 73.58  ? 59  VAL A CA  1 
ATOM   146  C  C   . VAL A 1 59  ? 109.561 98.378  104.976 1.00 73.58  ? 59  VAL A C   1 
ATOM   147  O  O   . VAL A 1 59  ? 110.429 99.206  105.276 1.00 73.58  ? 59  VAL A O   1 
ATOM   148  C  CB  . VAL A 1 59  ? 110.910 96.357  104.290 1.00 73.58  ? 59  VAL A CB  1 
ATOM   149  C  CG1 . VAL A 1 59  ? 110.614 95.783  105.665 1.00 73.58  ? 59  VAL A CG1 1 
ATOM   150  C  CG2 . VAL A 1 59  ? 111.018 95.242  103.266 1.00 73.58  ? 59  VAL A CG2 1 
ATOM   151  N  N   . GLY A 1 60  ? 108.374 98.321  105.574 1.00 69.57  ? 60  GLY A N   1 
ATOM   152  C  CA  . GLY A 1 60  ? 107.987 99.318  106.549 1.00 69.57  ? 60  GLY A CA  1 
ATOM   153  C  C   . GLY A 1 60  ? 106.538 99.240  106.980 1.00 69.57  ? 60  GLY A C   1 
ATOM   154  O  O   . GLY A 1 60  ? 106.056 98.176  107.376 1.00 69.57  ? 60  GLY A O   1 
ATOM   155  N  N   . LEU A 1 61  ? 105.838 100.376 106.919 1.00 65.15  ? 61  LEU A N   1 
ATOM   156  C  CA  . LEU A 1 61  ? 104.470 100.452 107.419 1.00 65.15  ? 61  LEU A CA  1 
ATOM   157  C  C   . LEU A 1 61  ? 103.482 99.688  106.548 1.00 65.15  ? 61  LEU A C   1 
ATOM   158  O  O   . LEU A 1 61  ? 102.483 99.178  107.063 1.00 65.15  ? 61  LEU A O   1 
ATOM   159  C  CB  . LEU A 1 61  ? 104.037 101.913 107.537 1.00 65.15  ? 61  LEU A CB  1 
ATOM   160  C  CG  . LEU A 1 61  ? 104.741 102.730 108.618 1.00 65.15  ? 61  LEU A CG  1 
ATOM   161  C  CD1 . LEU A 1 61  ? 104.373 104.195 108.510 1.00 65.15  ? 61  LEU A CD1 1 
ATOM   162  C  CD2 . LEU A 1 61  ? 104.385 102.194 109.981 1.00 65.15  ? 61  LEU A CD2 1 
ATOM   163  N  N   . GLY A 1 62  ? 103.732 99.593  105.244 1.00 62.30  ? 62  GLY A N   1 
ATOM   164  C  CA  . GLY A 1 62  ? 102.819 98.878  104.369 1.00 62.30  ? 62  GLY A CA  1 
ATOM   165  C  C   . GLY A 1 62  ? 102.747 97.386  104.614 1.00 62.30  ? 62  GLY A C   1 
ATOM   166  O  O   . GLY A 1 62  ? 101.794 96.750  104.152 1.00 62.30  ? 62  GLY A O   1 
ATOM   167  N  N   . ASN A 1 63  ? 103.722 96.816  105.320 1.00 65.78  ? 63  ASN A N   1 
ATOM   168  C  CA  . ASN A 1 63  ? 103.743 95.390  105.613 1.00 65.78  ? 63  ASN A CA  1 
ATOM   169  C  C   . ASN A 1 63  ? 103.249 95.060  107.013 1.00 65.78  ? 63  ASN A C   1 
ATOM   170  O  O   . ASN A 1 63  ? 102.878 93.910  107.266 1.00 65.78  ? 63  ASN A O   1 
ATOM   171  C  CB  . ASN A 1 63  ? 105.162 94.832  105.444 1.00 65.78  ? 63  ASN A CB  1 
ATOM   172  C  CG  . ASN A 1 63  ? 105.745 95.123  104.077 1.00 65.78  ? 63  ASN A CG  1 
ATOM   173  O  OD1 . ASN A 1 63  ? 105.125 95.794  103.258 1.00 65.78  ? 63  ASN A OD1 1 
ATOM   174  N  ND2 . ASN A 1 63  ? 106.937 94.605  103.821 1.00 65.78  ? 63  ASN A ND2 1 
ATOM   175  N  N   . VAL A 1 64  ? 103.229 96.034  107.919 1.00 69.07  ? 64  VAL A N   1 
ATOM   176  C  CA  . VAL A 1 64  ? 102.876 95.796  109.314 1.00 69.07  ? 64  VAL A CA  1 
ATOM   177  C  C   . VAL A 1 64  ? 101.576 96.475  109.718 1.00 69.07  ? 64  VAL A C   1 
ATOM   178  O  O   . VAL A 1 64  ? 100.882 95.967  110.613 1.00 69.07  ? 64  VAL A O   1 
ATOM   179  C  CB  . VAL A 1 64  ? 104.021 96.233  110.257 1.00 69.07  ? 64  VAL A CB  1 
ATOM   180  C  CG1 . VAL A 1 64  ? 103.685 95.956  111.714 1.00 69.07  ? 64  VAL A CG1 1 
ATOM   181  C  CG2 . VAL A 1 64  ? 105.316 95.541  109.874 1.00 69.07  ? 64  VAL A CG2 1 
ATOM   182  N  N   . TRP A 1 65  ? 101.196 97.577  109.070 1.00 63.88  ? 65  TRP A N   1 
ATOM   183  C  CA  . TRP A 1 65  ? 100.020 98.347  109.457 1.00 63.88  ? 65  TRP A CA  1 
ATOM   184  C  C   . TRP A 1 65  ? 98.884  98.214  108.451 1.00 63.88  ? 65  TRP A C   1 
ATOM   185  O  O   . TRP A 1 65  ? 97.764  97.873  108.845 1.00 63.88  ? 65  TRP A O   1 
ATOM   186  C  CB  . TRP A 1 65  ? 100.409 99.823  109.644 1.00 63.88  ? 65  TRP A CB  1 
ATOM   187  C  CG  . TRP A 1 65  ? 99.258  100.783 109.521 1.00 63.88  ? 65  TRP A CG  1 
ATOM   188  C  CD1 . TRP A 1 65  ? 98.302  101.041 110.459 1.00 63.88  ? 65  TRP A CD1 1 
ATOM   189  C  CD2 . TRP A 1 65  ? 98.946  101.611 108.394 1.00 63.88  ? 65  TRP A CD2 1 
ATOM   190  N  NE1 . TRP A 1 65  ? 97.415  101.976 109.986 1.00 63.88  ? 65  TRP A NE1 1 
ATOM   191  C  CE2 . TRP A 1 65  ? 97.788  102.341 108.720 1.00 63.88  ? 65  TRP A CE2 1 
ATOM   192  C  CE3 . TRP A 1 65  ? 99.534  101.805 107.142 1.00 63.88  ? 65  TRP A CE3 1 
ATOM   193  C  CZ2 . TRP A 1 65  ? 97.206  103.247 107.839 1.00 63.88  ? 65  TRP A CZ2 1 
ATOM   194  C  CZ3 . TRP A 1 65  ? 98.954  102.704 106.269 1.00 63.88  ? 65  TRP A CZ3 1 
ATOM   195  C  CH2 . TRP A 1 65  ? 97.803  103.414 106.621 1.00 63.88  ? 65  TRP A CH2 1 
ATOM   196  N  N   . ARG A 1 66  ? 99.127  98.474  107.163 1.00 61.23  ? 66  ARG A N   1 
ATOM   197  C  CA  . ARG A 1 66  ? 98.019  98.553  106.215 1.00 61.23  ? 66  ARG A CA  1 
ATOM   198  C  C   . ARG A 1 66  ? 97.505  97.174  105.814 1.00 61.23  ? 66  ARG A C   1 
ATOM   199  O  O   . ARG A 1 66  ? 96.291  96.969  105.711 1.00 61.23  ? 66  ARG A O   1 
ATOM   200  C  CB  . ARG A 1 66  ? 98.423  99.347  104.978 1.00 61.23  ? 66  ARG A CB  1 
ATOM   201  C  CG  . ARG A 1 66  ? 97.288  99.457  103.996 1.00 61.23  ? 66  ARG A CG  1 
ATOM   202  C  CD  . ARG A 1 66  ? 97.543  100.432 102.880 1.00 61.23  ? 66  ARG A CD  1 
ATOM   203  N  NE  . ARG A 1 66  ? 96.470  100.339 101.900 1.00 61.23  ? 66  ARG A NE  1 
ATOM   204  C  CZ  . ARG A 1 66  ? 96.324  101.143 100.859 1.00 61.23  ? 66  ARG A CZ  1 
ATOM   205  N  NH1 . ARG A 1 66  ? 97.155  102.147 100.641 1.00 61.23  ? 66  ARG A NH1 1 
ATOM   206  N  NH2 . ARG A 1 66  ? 95.315  100.939 100.021 1.00 61.23  ? 66  ARG A NH2 1 
ATOM   207  N  N   . PHE A 1 67  ? 98.408  96.227  105.572 1.00 61.18  ? 67  PHE A N   1 
ATOM   208  C  CA  . PHE A 1 67  ? 98.000  94.876  105.185 1.00 61.18  ? 67  PHE A CA  1 
ATOM   209  C  C   . PHE A 1 67  ? 97.015  94.251  106.169 1.00 61.18  ? 67  PHE A C   1 
ATOM   210  O  O   . PHE A 1 67  ? 95.991  93.699  105.720 1.00 61.18  ? 67  PHE A O   1 
ATOM   211  C  CB  . PHE A 1 67  ? 99.262  94.021  105.004 1.00 61.18  ? 67  PHE A CB  1 
ATOM   212  C  CG  . PHE A 1 67  ? 99.000  92.584  104.641 1.00 61.18  ? 67  PHE A CG  1 
ATOM   213  C  CD1 . PHE A 1 67  ? 98.791  92.213  103.325 1.00 61.18  ? 67  PHE A CD1 1 
ATOM   214  C  CD2 . PHE A 1 67  ? 99.002  91.599  105.614 1.00 61.18  ? 67  PHE A CD2 1 
ATOM   215  C  CE1 . PHE A 1 67  ? 98.567  90.892  102.992 1.00 61.18  ? 67  PHE A CE1 1 
ATOM   216  C  CE2 . PHE A 1 67  ? 98.779  90.280  105.286 1.00 61.18  ? 67  PHE A CE2 1 
ATOM   217  C  CZ  . PHE A 1 67  ? 98.561  89.926  103.974 1.00 61.18  ? 67  PHE A CZ  1 
ATOM   218  N  N   . PRO A 1 68  ? 97.236  94.300  107.490 1.00 63.13  ? 68  PRO A N   1 
ATOM   219  C  CA  . PRO A 1 68  ? 96.286  93.638  108.398 1.00 63.13  ? 68  PRO A CA  1 
ATOM   220  C  C   . PRO A 1 68  ? 94.857  94.154  108.329 1.00 63.13  ? 68  PRO A C   1 
ATOM   221  O  O   . PRO A 1 68  ? 93.934  93.335  108.368 1.00 63.13  ? 68  PRO A O   1 
ATOM   222  C  CB  . PRO A 1 68  ? 96.915  93.874  109.777 1.00 63.13  ? 68  PRO A CB  1 
ATOM   223  C  CG  . PRO A 1 68  ? 98.351  94.015  109.504 1.00 63.13  ? 68  PRO A CG  1 
ATOM   224  C  CD  . PRO A 1 68  ? 98.421  94.777  108.224 1.00 63.13  ? 68  PRO A CD  1 
ATOM   225  N  N   . TYR A 1 69  ? 94.614  95.468  108.226 1.00 64.17  ? 69  TYR A N   1 
ATOM   226  C  CA  . TYR A 1 69  ? 93.218  95.884  108.336 1.00 64.17  ? 69  TYR A CA  1 
ATOM   227  C  C   . TYR A 1 69  ? 92.503  95.716  107.004 1.00 64.17  ? 69  TYR A C   1 
ATOM   228  O  O   . TYR A 1 69  ? 91.276  95.596  106.968 1.00 64.17  ? 69  TYR A O   1 
ATOM   229  C  CB  . TYR A 1 69  ? 93.059  97.327  108.824 1.00 64.17  ? 69  TYR A CB  1 
ATOM   230  C  CG  . TYR A 1 69  ? 93.449  98.432  107.871 1.00 64.17  ? 69  TYR A CG  1 
ATOM   231  C  CD1 . TYR A 1 69  ? 94.728  98.950  107.835 1.00 64.17  ? 69  TYR A CD1 1 
ATOM   232  C  CD2 . TYR A 1 69  ? 92.493  98.987  107.026 1.00 64.17  ? 69  TYR A CD2 1 
ATOM   233  C  CE1 . TYR A 1 69  ? 95.046  99.977  106.967 1.00 64.17  ? 69  TYR A CE1 1 
ATOM   234  C  CE2 . TYR A 1 69  ? 92.803  100.000 106.159 1.00 64.17  ? 69  TYR A CE2 1 
ATOM   235  C  CZ  . TYR A 1 69  ? 94.079  100.493 106.130 1.00 64.17  ? 69  TYR A CZ  1 
ATOM   236  O  OH  . TYR A 1 69  ? 94.388  101.509 105.261 1.00 64.17  ? 69  TYR A OH  1 
ATOM   237  N  N   . LEU A 1 70  ? 93.246  95.730  105.897 1.00 63.66  ? 70  LEU A N   1 
ATOM   238  C  CA  . LEU A 1 70  ? 92.655  95.358  104.617 1.00 63.66  ? 70  LEU A CA  1 
ATOM   239  C  C   . LEU A 1 70  ? 92.267  93.885  104.611 1.00 63.66  ? 70  LEU A C   1 
ATOM   240  O  O   . LEU A 1 70  ? 91.216  93.511  104.081 1.00 63.66  ? 70  LEU A O   1 
ATOM   241  C  CB  . LEU A 1 70  ? 93.615  95.675  103.474 1.00 63.66  ? 70  LEU A CB  1 
ATOM   242  C  CG  . LEU A 1 70  ? 93.667  97.145  103.064 1.00 63.66  ? 70  LEU A CG  1 
ATOM   243  C  CD1 . LEU A 1 70  ? 94.621  97.343  101.904 1.00 63.66  ? 70  LEU A CD1 1 
ATOM   244  C  CD2 . LEU A 1 70  ? 92.281  97.646  102.709 1.00 63.66  ? 70  LEU A CD2 1 
ATOM   245  N  N   . CYS A 1 71  ? 93.109  93.029  105.195 1.00 69.09  ? 71  CYS A N   1 
ATOM   246  C  CA  . CYS A 1 71  ? 92.728  91.626  105.333 1.00 69.09  ? 71  CYS A CA  1 
ATOM   247  C  C   . CYS A 1 71  ? 91.538  91.464  106.276 1.00 69.09  ? 71  CYS A C   1 
ATOM   248  O  O   . CYS A 1 71  ? 90.674  90.609  106.056 1.00 69.09  ? 71  CYS A O   1 
ATOM   249  C  CB  . CYS A 1 71  ? 93.920  90.804  105.821 1.00 69.09  ? 71  CYS A CB  1 
ATOM   250  S  SG  . CYS A 1 71  ? 93.678  89.016  105.756 1.00 69.09  ? 71  CYS A SG  1 
ATOM   251  N  N   . TYR A 1 72  ? 91.487  92.273  107.336 1.00 67.85  ? 72  TYR A N   1 
ATOM   252  C  CA  . TYR A 1 72  ? 90.445  92.142  108.351 1.00 67.85  ? 72  TYR A CA  1 
ATOM   253  C  C   . TYR A 1 72  ? 89.105  92.675  107.860 1.00 67.85  ? 72  TYR A C   1 
ATOM   254  O  O   . TYR A 1 72  ? 88.048  92.145  108.218 1.00 67.85  ? 72  TYR A O   1 
ATOM   255  C  CB  . TYR A 1 72  ? 90.889  92.874  109.616 1.00 67.85  ? 72  TYR A CB  1 
ATOM   256  C  CG  . TYR A 1 72  ? 89.893  92.873  110.745 1.00 67.85  ? 72  TYR A CG  1 
ATOM   257  C  CD1 . TYR A 1 72  ? 89.534  91.696  111.378 1.00 67.85  ? 72  TYR A CD1 1 
ATOM   258  C  CD2 . TYR A 1 72  ? 89.335  94.056  111.198 1.00 67.85  ? 72  TYR A CD2 1 
ATOM   259  C  CE1 . TYR A 1 72  ? 88.634  91.695  112.419 1.00 67.85  ? 72  TYR A CE1 1 
ATOM   260  C  CE2 . TYR A 1 72  ? 88.436  94.066  112.237 1.00 67.85  ? 72  TYR A CE2 1 
ATOM   261  C  CZ  . TYR A 1 72  ? 88.089  92.883  112.844 1.00 67.85  ? 72  TYR A CZ  1 
ATOM   262  O  OH  . TYR A 1 72  ? 87.192  92.887  113.882 1.00 67.85  ? 72  TYR A OH  1 
ATOM   263  N  N   . LYS A 1 73  ? 89.131  93.732  107.047 1.00 67.73  ? 73  LYS A N   1 
ATOM   264  C  CA  . LYS A 1 73  ? 87.902  94.337  106.548 1.00 67.73  ? 73  LYS A CA  1 
ATOM   265  C  C   . LYS A 1 73  ? 87.106  93.343  105.715 1.00 67.73  ? 73  LYS A C   1 
ATOM   266  O  O   . LYS A 1 73  ? 85.876  93.273  105.812 1.00 67.73  ? 73  LYS A O   1 
ATOM   267  C  CB  . LYS A 1 73  ? 88.244  95.583  105.731 1.00 67.73  ? 73  LYS A CB  1 
ATOM   268  C  CG  . LYS A 1 73  ? 87.088  96.524  105.491 1.00 67.73  ? 73  LYS A CG  1 
ATOM   269  C  CD  . LYS A 1 73  ? 87.588  97.866  104.996 1.00 67.73  ? 73  LYS A CD  1 
ATOM   270  C  CE  . LYS A 1 73  ? 87.866  97.835  103.506 1.00 67.73  ? 73  LYS A CE  1 
ATOM   271  N  NZ  . LYS A 1 73  ? 86.613  97.818  102.707 1.00 67.73  ? 73  LYS A NZ  1 
ATOM   272  N  N   . ASN A 1 74  ? 87.797  92.566  104.889 1.00 70.73  ? 74  ASN A N   1 
ATOM   273  C  CA  . ASN A 1 74  ? 87.177  91.501  104.122 1.00 70.73  ? 74  ASN A CA  1 
ATOM   274  C  C   . ASN A 1 74  ? 87.102  90.232  104.969 1.00 70.73  ? 74  ASN A C   1 
ATOM   275  O  O   . ASN A 1 74  ? 87.306  90.249  106.186 1.00 70.73  ? 74  ASN A O   1 
ATOM   276  C  CB  . ASN A 1 74  ? 87.952  91.275  102.830 1.00 70.73  ? 74  ASN A CB  1 
ATOM   277  C  CG  . ASN A 1 74  ? 88.145  92.555  102.047 1.00 70.73  ? 74  ASN A CG  1 
ATOM   278  O  OD1 . ASN A 1 74  ? 87.197  93.300  101.815 1.00 70.73  ? 74  ASN A OD1 1 
ATOM   279  N  ND2 . ASN A 1 74  ? 89.379  92.825  101.649 1.00 70.73  ? 74  ASN A ND2 1 
ATOM   280  N  N   . GLY A 1 75  ? 86.791  89.111  104.322 1.00 75.86  ? 75  GLY A N   1 
ATOM   281  C  CA  . GLY A 1 75  ? 86.658  87.864  105.055 1.00 75.86  ? 75  GLY A CA  1 
ATOM   282  C  C   . GLY A 1 75  ? 87.964  87.342  105.622 1.00 75.86  ? 75  GLY A C   1 
ATOM   283  O  O   . GLY A 1 75  ? 88.002  86.867  106.759 1.00 75.86  ? 75  GLY A O   1 
ATOM   284  N  N   . GLY A 1 76  ? 89.044  87.420  104.850 1.00 76.23  ? 76  GLY A N   1 
ATOM   285  C  CA  . GLY A 1 76  ? 90.289  86.774  105.222 1.00 76.23  ? 76  GLY A CA  1 
ATOM   286  C  C   . GLY A 1 76  ? 90.447  85.441  104.518 1.00 76.23  ? 76  GLY A C   1 
ATOM   287  O  O   . GLY A 1 76  ? 89.571  84.577  104.615 1.00 76.23  ? 76  GLY A O   1 
ATOM   288  N  N   . GLY A 1 77  ? 91.557  85.256  103.816 1.00 73.66  ? 77  GLY A N   1 
ATOM   289  C  CA  . GLY A 1 77  ? 91.715  84.096  102.935 1.00 73.66  ? 77  GLY A CA  1 
ATOM   290  C  C   . GLY A 1 77  ? 91.136  84.353  101.567 1.00 73.66  ? 77  GLY A C   1 
ATOM   291  O  O   . GLY A 1 77  ? 91.837  84.226  100.555 1.00 73.66  ? 77  GLY A O   1 
ATOM   292  N  N   . ALA A 1 78  ? 89.857  84.729  101.509 1.00 74.18  ? 78  ALA A N   1 
ATOM   293  C  CA  . ALA A 1 78  ? 89.292  85.254  100.275 1.00 74.18  ? 78  ALA A CA  1 
ATOM   294  C  C   . ALA A 1 78  ? 89.992  86.532  99.851  1.00 74.18  ? 78  ALA A C   1 
ATOM   295  O  O   . ALA A 1 78  ? 89.866  86.944  98.695  1.00 74.18  ? 78  ALA A O   1 
ATOM   296  C  CB  . ALA A 1 78  ? 87.794  85.504  100.442 1.00 74.18  ? 78  ALA A CB  1 
ATOM   297  N  N   . PHE A 1 79  ? 90.702  87.179  100.775 1.00 69.01  ? 79  PHE A N   1 
ATOM   298  C  CA  . PHE A 1 79  ? 91.625  88.247  100.422 1.00 69.01  ? 79  PHE A CA  1 
ATOM   299  C  C   . PHE A 1 79  ? 92.967  87.690  99.962  1.00 69.01  ? 79  PHE A C   1 
ATOM   300  O  O   . PHE A 1 79  ? 93.655  88.327  99.157  1.00 69.01  ? 79  PHE A O   1 
ATOM   301  C  CB  . PHE A 1 79  ? 91.798  89.185  101.622 1.00 69.01  ? 79  PHE A CB  1 
ATOM   302  C  CG  . PHE A 1 79  ? 92.877  90.216  101.451 1.00 69.01  ? 79  PHE A CG  1 
ATOM   303  C  CD1 . PHE A 1 79  ? 94.152  89.997  101.945 1.00 69.01  ? 79  PHE A CD1 1 
ATOM   304  C  CD2 . PHE A 1 79  ? 92.612  91.412  100.809 1.00 69.01  ? 79  PHE A CD2 1 
ATOM   305  C  CE1 . PHE A 1 79  ? 95.140  90.946  101.792 1.00 69.01  ? 79  PHE A CE1 1 
ATOM   306  C  CE2 . PHE A 1 79  ? 93.599  92.364  100.657 1.00 69.01  ? 79  PHE A CE2 1 
ATOM   307  C  CZ  . PHE A 1 79  ? 94.864  92.131  101.146 1.00 69.01  ? 79  PHE A CZ  1 
ATOM   308  N  N   . LEU A 1 80  ? 93.344  86.501  100.446 1.00 66.95  ? 80  LEU A N   1 
ATOM   309  C  CA  . LEU A 1 80  ? 94.644  85.930  100.106 1.00 66.95  ? 80  LEU A CA  1 
ATOM   310  C  C   . LEU A 1 80  ? 94.674  85.393  98.680  1.00 66.95  ? 80  LEU A C   1 
ATOM   311  O  O   . LEU A 1 80  ? 95.712  85.466  98.012  1.00 66.95  ? 80  LEU A O   1 
ATOM   312  C  CB  . LEU A 1 80  ? 95.016  84.823  101.093 1.00 66.95  ? 80  LEU A CB  1 
ATOM   313  C  CG  . LEU A 1 80  ? 95.408  85.225  102.515 1.00 66.95  ? 80  LEU A CG  1 
ATOM   314  C  CD1 . LEU A 1 80  ? 95.883  84.014  103.296 1.00 66.95  ? 80  LEU A CD1 1 
ATOM   315  C  CD2 . LEU A 1 80  ? 96.482  86.296  102.490 1.00 66.95  ? 80  LEU A CD2 1 
ATOM   316  N  N   . ILE A 1 81  ? 93.566  84.832  98.203  1.00 67.77  ? 81  ILE A N   1 
ATOM   317  C  CA  . ILE A 1 81  ? 93.548  84.240  96.862  1.00 67.77  ? 81  ILE A CA  1 
ATOM   318  C  C   . ILE A 1 81  ? 93.881  85.293  95.803  1.00 67.77  ? 81  ILE A C   1 
ATOM   319  O  O   . ILE A 1 81  ? 94.856  85.110  95.048  1.00 67.77  ? 81  ILE A O   1 
ATOM   320  C  CB  . ILE A 1 81  ? 92.202  83.552  96.569  1.00 67.77  ? 81  ILE A CB  1 
ATOM   321  C  CG1 . ILE A 1 81  ? 91.824  82.594  97.701  1.00 67.77  ? 81  ILE A CG1 1 
ATOM   322  C  CG2 . ILE A 1 81  ? 92.245  82.839  95.230  1.00 67.77  ? 81  ILE A CG2 1 
ATOM   323  C  CD1 . ILE A 1 81  ? 92.622  81.315  97.713  1.00 67.77  ? 81  ILE A CD1 1 
ATOM   324  N  N   . PRO A 1 82  ? 93.146  86.412  95.708  1.00 68.50  ? 82  PRO A N   1 
ATOM   325  C  CA  . PRO A 1 82  ? 93.565  87.455  94.760  1.00 68.50  ? 82  PRO A CA  1 
ATOM   326  C  C   . PRO A 1 82  ? 94.911  88.051  95.106  1.00 68.50  ? 82  PRO A C   1 
ATOM   327  O  O   . PRO A 1 82  ? 95.610  88.531  94.210  1.00 68.50  ? 82  PRO A O   1 
ATOM   328  C  CB  . PRO A 1 82  ? 92.442  88.499  94.857  1.00 68.50  ? 82  PRO A CB  1 
ATOM   329  C  CG  . PRO A 1 82  ? 91.312  87.801  95.501  1.00 68.50  ? 82  PRO A CG  1 
ATOM   330  C  CD  . PRO A 1 82  ? 91.944  86.839  96.442  1.00 68.50  ? 82  PRO A CD  1 
ATOM   331  N  N   . TYR A 1 83  ? 95.344  88.170  96.377  1.00 66.21  ? 83  TYR A N   1 
ATOM   332  C  CA  . TYR A 1 83  ? 96.704  88.610  96.735  1.00 66.21  ? 83  TYR A CA  1 
ATOM   333  C  C   . TYR A 1 83  ? 97.757  87.780  96.059  1.00 66.21  ? 83  TYR A C   1 
ATOM   334  O  O   . TYR A 1 83  ? 98.558  88.322  95.354  1.00 66.21  ? 83  TYR A O   1 
ATOM   335  C  CB  . TYR A 1 83  ? 96.850  88.456  98.195  1.00 66.21  ? 83  TYR A CB  1 
ATOM   336  C  CG  . TYR A 1 83  ? 98.165  88.857  98.775  1.00 66.21  ? 83  TYR A CG  1 
ATOM   337  C  CD1 . TYR A 1 83  ? 98.553  90.179  98.800  1.00 66.21  ? 83  TYR A CD1 1 
ATOM   338  C  CD2 . TYR A 1 83  ? 99.003  87.917  99.349  1.00 66.21  ? 83  TYR A CD2 1 
ATOM   339  C  CE1 . TYR A 1 83  ? 99.757  90.548  99.344  1.00 66.21  ? 83  TYR A CE1 1 
ATOM   340  C  CE2 . TYR A 1 83  ? 100.210 88.282  99.887  1.00 66.21  ? 83  TYR A CE2 1 
ATOM   341  C  CZ  . TYR A 1 83  ? 100.576 89.601  99.877  1.00 66.21  ? 83  TYR A CZ  1 
ATOM   342  O  OH  . TYR A 1 83  ? 101.759 89.983  100.424 1.00 66.21  ? 83  TYR A OH  1 
ATOM   343  N  N   . PHE A 1 84  ? 97.730  86.448  96.204  1.00 66.50  ? 84  PHE A N   1 
ATOM   344  C  CA  . PHE A 1 84  ? 98.793  85.667  95.576  1.00 66.50  ? 84  PHE A CA  1 
ATOM   345  C  C   . PHE A 1 84  ? 98.660  85.661  94.058  1.00 66.50  ? 84  PHE A C   1 
ATOM   346  O  O   . PHE A 1 84  ? 99.673  85.649  93.339  1.00 66.50  ? 84  PHE A O   1 
ATOM   347  C  CB  . PHE A 1 84  ? 98.799  84.244  96.128  1.00 66.50  ? 84  PHE A CB  1 
ATOM   348  C  CG  . PHE A 1 84  ? 99.362  84.142  97.514  1.00 66.50  ? 84  PHE A CG  1 
ATOM   349  C  CD1 . PHE A 1 84  ? 100.678 84.488  97.765  1.00 66.50  ? 84  PHE A CD1 1 
ATOM   350  C  CD2 . PHE A 1 84  ? 98.578  83.707  98.566  1.00 66.50  ? 84  PHE A CD2 1 
ATOM   351  C  CE1 . PHE A 1 84  ? 101.200 84.400  99.036  1.00 66.50  ? 84  PHE A CE1 1 
ATOM   352  C  CE2 . PHE A 1 84  ? 99.096  83.617  99.840  1.00 66.50  ? 84  PHE A CE2 1 
ATOM   353  C  CZ  . PHE A 1 84  ? 100.408 83.963  100.075 1.00 66.50  ? 84  PHE A CZ  1 
ATOM   354  N  N   . ILE A 1 85  ? 97.424  85.664  93.547  1.00 65.77  ? 85  ILE A N   1 
ATOM   355  C  CA  . ILE A 1 85  ? 97.243  85.745  92.099  1.00 65.77  ? 85  ILE A CA  1 
ATOM   356  C  C   . ILE A 1 85  ? 97.887  87.017  91.561  1.00 65.77  ? 85  ILE A C   1 
ATOM   357  O  O   . ILE A 1 85  ? 98.681  86.978  90.614  1.00 65.77  ? 85  ILE A O   1 
ATOM   358  C  CB  . ILE A 1 85  ? 95.751  85.665  91.730  1.00 65.77  ? 85  ILE A CB  1 
ATOM   359  C  CG1 . ILE A 1 85  ? 95.281  84.211  91.725  1.00 65.77  ? 85  ILE A CG1 1 
ATOM   360  C  CG2 . ILE A 1 85  ? 95.504  86.285  90.366  1.00 65.77  ? 85  ILE A CG2 1 
ATOM   361  C  CD1 . ILE A 1 85  ? 93.781  84.060  91.668  1.00 65.77  ? 85  ILE A CD1 1 
ATOM   362  N  N   . PHE A 1 86  ? 97.590  88.158  92.189  1.00 67.96  ? 86  PHE A N   1 
ATOM   363  C  CA  . PHE A 1 86  ? 98.188  89.422  91.780  1.00 67.96  ? 86  PHE A CA  1 
ATOM   364  C  C   . PHE A 1 86  ? 99.693  89.430  92.001  1.00 67.96  ? 86  PHE A C   1 
ATOM   365  O  O   . PHE A 1 86  ? 100.425 89.994  91.184  1.00 67.96  ? 86  PHE A O   1 
ATOM   366  C  CB  . PHE A 1 86  ? 97.538  90.582  92.531  1.00 67.96  ? 86  PHE A CB  1 
ATOM   367  C  CG  . PHE A 1 86  ? 96.399  91.218  91.790  1.00 67.96  ? 86  PHE A CG  1 
ATOM   368  C  CD1 . PHE A 1 86  ? 95.104  90.763  91.963  1.00 67.96  ? 86  PHE A CD1 1 
ATOM   369  C  CD2 . PHE A 1 86  ? 96.626  92.263  90.910  1.00 67.96  ? 86  PHE A CD2 1 
ATOM   370  C  CE1 . PHE A 1 86  ? 94.056  91.342  91.281  1.00 67.96  ? 86  PHE A CE1 1 
ATOM   371  C  CE2 . PHE A 1 86  ? 95.581  92.846  90.223  1.00 67.96  ? 86  PHE A CE2 1 
ATOM   372  C  CZ  . PHE A 1 86  ? 94.295  92.384  90.408  1.00 67.96  ? 86  PHE A CZ  1 
ATOM   373  N  N   . LEU A 1 87  ? 100.171 88.808  93.081  1.00 68.07  ? 87  LEU A N   1 
ATOM   374  C  CA  . LEU A 1 87  ? 101.608 88.726  93.314  1.00 68.07  ? 87  LEU A CA  1 
ATOM   375  C  C   . LEU A 1 87  ? 102.309 88.089  92.124  1.00 68.07  ? 87  LEU A C   1 
ATOM   376  O  O   . LEU A 1 87  ? 102.997 88.775  91.361  1.00 68.07  ? 87  LEU A O   1 
ATOM   377  C  CB  . LEU A 1 87  ? 101.886 87.934  94.594  1.00 68.07  ? 87  LEU A CB  1 
ATOM   378  C  CG  . LEU A 1 87  ? 103.349 87.642  94.936  1.00 68.07  ? 87  LEU A CG  1 
ATOM   379  C  CD1 . LEU A 1 87  ? 104.156 88.925  95.009  1.00 68.07  ? 87  LEU A CD1 1 
ATOM   380  C  CD2 . LEU A 1 87  ? 103.452 86.868  96.239  1.00 68.07  ? 87  LEU A CD2 1 
ATOM   381  N  N   . PHE A 1 88  ? 102.043 86.802  91.888  1.00 67.79  ? 88  PHE A N   1 
ATOM   382  C  CA  . PHE A 1 88  ? 102.750 86.083  90.830  1.00 67.79  ? 88  PHE A CA  1 
ATOM   383  C  C   . PHE A 1 88  ? 102.343 86.552  89.438  1.00 67.79  ? 88  PHE A C   1 
ATOM   384  O  O   . PHE A 1 88  ? 102.999 86.202  88.452  1.00 67.79  ? 88  PHE A O   1 
ATOM   385  C  CB  . PHE A 1 88  ? 102.541 84.578  90.979  1.00 67.79  ? 88  PHE A CB  1 
ATOM   386  C  CG  . PHE A 1 88  ? 103.068 84.022  92.268  1.00 67.79  ? 88  PHE A CG  1 
ATOM   387  C  CD1 . PHE A 1 88  ? 104.380 84.250  92.641  1.00 67.79  ? 88  PHE A CD1 1 
ATOM   388  C  CD2 . PHE A 1 88  ? 102.256 83.283  93.107  1.00 67.79  ? 88  PHE A CD2 1 
ATOM   389  C  CE1 . PHE A 1 88  ? 104.876 83.745  93.823  1.00 67.79  ? 88  PHE A CE1 1 
ATOM   390  C  CE2 . PHE A 1 88  ? 102.746 82.776  94.295  1.00 67.79  ? 88  PHE A CE2 1 
ATOM   391  C  CZ  . PHE A 1 88  ? 104.058 83.008  94.652  1.00 67.79  ? 88  PHE A CZ  1 
ATOM   392  N  N   . GLY A 1 89  ? 101.269 87.335  89.323  1.00 68.93  ? 89  GLY A N   1 
ATOM   393  C  CA  . GLY A 1 89  ? 100.894 87.843  88.015  1.00 68.93  ? 89  GLY A CA  1 
ATOM   394  C  C   . GLY A 1 89  ? 101.584 89.144  87.656  1.00 68.93  ? 89  GLY A C   1 
ATOM   395  O  O   . GLY A 1 89  ? 102.086 89.300  86.540  1.00 68.93  ? 89  GLY A O   1 
ATOM   396  N  N   . SER A 1 90  ? 101.611 90.097  88.583  1.00 72.72  ? 90  SER A N   1 
ATOM   397  C  CA  . SER A 1 90  ? 102.065 91.447  88.280  1.00 72.72  ? 90  SER A CA  1 
ATOM   398  C  C   . SER A 1 90  ? 103.078 92.001  89.272  1.00 72.72  ? 90  SER A C   1 
ATOM   399  O  O   . SER A 1 90  ? 103.902 92.832  88.887  1.00 72.72  ? 90  SER A O   1 
ATOM   400  C  CB  . SER A 1 90  ? 100.850 92.383  88.214  1.00 72.72  ? 90  SER A CB  1 
ATOM   401  O  OG  . SER A 1 90  ? 101.231 93.686  87.814  1.00 72.72  ? 90  SER A OG  1 
ATOM   402  N  N   . GLY A 1 91  ? 103.036 91.576  90.537  1.00 74.92  ? 91  GLY A N   1 
ATOM   403  C  CA  . GLY A 1 91  ? 103.800 92.276  91.559  1.00 74.92  ? 91  GLY A CA  1 
ATOM   404  C  C   . GLY A 1 91  ? 105.296 92.208  91.333  1.00 74.92  ? 91  GLY A C   1 
ATOM   405  O  O   . GLY A 1 91  ? 105.995 93.221  91.399  1.00 74.92  ? 91  GLY A O   1 
ATOM   406  N  N   . LEU A 1 92  ? 105.807 91.016  91.049  1.00 73.90  ? 92  LEU A N   1 
ATOM   407  C  CA  . LEU A 1 92  ? 107.231 90.833  90.803  1.00 73.90  ? 92  LEU A CA  1 
ATOM   408  C  C   . LEU A 1 92  ? 107.628 91.279  89.396  1.00 73.90  ? 92  LEU A C   1 
ATOM   409  O  O   . LEU A 1 92  ? 108.658 91.950  89.245  1.00 73.90  ? 92  LEU A O   1 
ATOM   410  C  CB  . LEU A 1 92  ? 107.632 89.375  91.039  1.00 73.90  ? 92  LEU A CB  1 
ATOM   411  C  CG  . LEU A 1 92  ? 107.634 88.905  92.495  1.00 73.90  ? 92  LEU A CG  1 
ATOM   412  C  CD1 . LEU A 1 92  ? 107.636 87.390  92.570  1.00 73.90  ? 92  LEU A CD1 1 
ATOM   413  C  CD2 . LEU A 1 92  ? 108.825 89.478  93.238  1.00 73.90  ? 92  LEU A CD2 1 
ATOM   414  N  N   . PRO A 1 93  ? 106.880 90.918  88.341  1.00 75.31  ? 93  PRO A N   1 
ATOM   415  C  CA  . PRO A 1 93  ? 107.266 91.389  86.999  1.00 75.31  ? 93  PRO A CA  1 
ATOM   416  C  C   . PRO A 1 93  ? 107.351 92.901  86.862  1.00 75.31  ? 93  PRO A C   1 
ATOM   417  O  O   . PRO A 1 93  ? 108.295 93.395  86.239  1.00 75.31  ? 93  PRO A O   1 
ATOM   418  C  CB  . PRO A 1 93  ? 106.172 90.796  86.104  1.00 75.31  ? 93  PRO A CB  1 
ATOM   419  C  CG  . PRO A 1 93  ? 105.768 89.567  86.800  1.00 75.31  ? 93  PRO A CG  1 
ATOM   420  C  CD  . PRO A 1 93  ? 105.797 89.918  88.254  1.00 75.31  ? 93  PRO A CD  1 
ATOM   421  N  N   . VAL A 1 94  ? 106.418 93.658  87.444  1.00 75.34  ? 94  VAL A N   1 
ATOM   422  C  CA  . VAL A 1 94  ? 106.460 95.111  87.295  1.00 75.34  ? 94  VAL A CA  1 
ATOM   423  C  C   . VAL A 1 94  ? 107.601 95.707  88.115  1.00 75.34  ? 94  VAL A C   1 
ATOM   424  O  O   . VAL A 1 94  ? 108.247 96.672  87.692  1.00 75.34  ? 94  VAL A O   1 
ATOM   425  C  CB  . VAL A 1 94  ? 105.101 95.734  87.663  1.00 75.34  ? 94  VAL A CB  1 
ATOM   426  C  CG1 . VAL A 1 94  ? 105.141 97.238  87.469  1.00 75.34  ? 94  VAL A CG1 1 
ATOM   427  C  CG2 . VAL A 1 94  ? 104.001 95.138  86.805  1.00 75.34  ? 94  VAL A CG2 1 
ATOM   428  N  N   . PHE A 1 95  ? 107.866 95.149  89.298  1.00 75.56  ? 95  PHE A N   1 
ATOM   429  C  CA  . PHE A 1 95  ? 109.006 95.595  90.097  1.00 75.56  ? 95  PHE A CA  1 
ATOM   430  C  C   . PHE A 1 95  ? 110.319 95.379  89.350  1.00 75.56  ? 95  PHE A C   1 
ATOM   431  O  O   . PHE A 1 95  ? 111.158 96.289  89.256  1.00 75.56  ? 95  PHE A O   1 
ATOM   432  C  CB  . PHE A 1 95  ? 109.004 94.854  91.435  1.00 75.56  ? 95  PHE A CB  1 
ATOM   433  C  CG  . PHE A 1 95  ? 110.269 95.007  92.229  1.00 75.56  ? 95  PHE A CG  1 
ATOM   434  C  CD1 . PHE A 1 95  ? 110.839 96.251  92.434  1.00 75.56  ? 95  PHE A CD1 1 
ATOM   435  C  CD2 . PHE A 1 95  ? 110.878 93.900  92.792  1.00 75.56  ? 95  PHE A CD2 1 
ATOM   436  C  CE1 . PHE A 1 95  ? 111.998 96.383  93.171  1.00 75.56  ? 95  PHE A CE1 1 
ATOM   437  C  CE2 . PHE A 1 95  ? 112.033 94.028  93.531  1.00 75.56  ? 95  PHE A CE2 1 
ATOM   438  C  CZ  . PHE A 1 95  ? 112.594 95.271  93.719  1.00 75.56  ? 95  PHE A CZ  1 
ATOM   439  N  N   . PHE A 1 96  ? 110.506 94.180  88.798  1.00 77.37  ? 96  PHE A N   1 
ATOM   440  C  CA  . PHE A 1 96  ? 111.714 93.905  88.030  1.00 77.37  ? 96  PHE A CA  1 
ATOM   441  C  C   . PHE A 1 96  ? 111.786 94.792  86.796  1.00 77.37  ? 96  PHE A C   1 
ATOM   442  O  O   . PHE A 1 96  ? 112.871 95.230  86.400  1.00 77.37  ? 96  PHE A O   1 
ATOM   443  C  CB  . PHE A 1 96  ? 111.762 92.426  87.648  1.00 77.37  ? 96  PHE A CB  1 
ATOM   444  C  CG  . PHE A 1 96  ? 112.948 92.052  86.807  1.00 77.37  ? 96  PHE A CG  1 
ATOM   445  C  CD1 . PHE A 1 96  ? 114.177 91.807  87.392  1.00 77.37  ? 96  PHE A CD1 1 
ATOM   446  C  CD2 . PHE A 1 96  ? 112.832 91.928  85.434  1.00 77.37  ? 96  PHE A CD2 1 
ATOM   447  C  CE1 . PHE A 1 96  ? 115.267 91.459  86.621  1.00 77.37  ? 96  PHE A CE1 1 
ATOM   448  C  CE2 . PHE A 1 96  ? 113.918 91.574  84.661  1.00 77.37  ? 96  PHE A CE2 1 
ATOM   449  C  CZ  . PHE A 1 96  ? 115.137 91.339  85.256  1.00 77.37  ? 96  PHE A CZ  1 
ATOM   450  N  N   . LEU A 1 97  ? 110.637 95.072  86.177  1.00 76.44  ? 97  LEU A N   1 
ATOM   451  C  CA  . LEU A 1 97  ? 110.607 95.956  85.019  1.00 76.44  ? 97  LEU A CA  1 
ATOM   452  C  C   . LEU A 1 97  ? 111.066 97.361  85.380  1.00 76.44  ? 97  LEU A C   1 
ATOM   453  O  O   . LEU A 1 97  ? 111.834 97.979  84.637  1.00 76.44  ? 97  LEU A O   1 
ATOM   454  C  CB  . LEU A 1 97  ? 109.197 95.988  84.437  1.00 76.44  ? 97  LEU A CB  1 
ATOM   455  C  CG  . LEU A 1 97  ? 108.952 96.978  83.305  1.00 76.44  ? 97  LEU A CG  1 
ATOM   456  C  CD1 . LEU A 1 97  ? 109.684 96.528  82.062  1.00 76.44  ? 97  LEU A CD1 1 
ATOM   457  C  CD2 . LEU A 1 97  ? 107.468 97.107  83.044  1.00 76.44  ? 97  LEU A CD2 1 
ATOM   458  N  N   . GLU A 1 98  ? 110.601 97.885  86.516  1.00 80.43  ? 98  GLU A N   1 
ATOM   459  C  CA  . GLU A 1 98  ? 111.036 99.210  86.949  1.00 80.43  ? 98  GLU A CA  1 
ATOM   460  C  C   . GLU A 1 98  ? 112.533 99.234  87.231  1.00 80.43  ? 98  GLU A C   1 
ATOM   461  O  O   . GLU A 1 98  ? 113.233 100.178 86.839  1.00 80.43  ? 98  GLU A O   1 
ATOM   462  C  CB  . GLU A 1 98  ? 110.254 99.645  88.186  1.00 80.43  ? 98  GLU A CB  1 
ATOM   463  C  CG  . GLU A 1 98  ? 108.764 99.796  87.960  1.00 80.43  ? 98  GLU A CG  1 
ATOM   464  C  CD  . GLU A 1 98  ? 108.083 100.536 89.092  1.00 80.43  ? 98  GLU A CD  1 
ATOM   465  O  OE1 . GLU A 1 98  ? 107.472 99.872  89.955  1.00 80.43  ? 98  GLU A OE1 1 
ATOM   466  O  OE2 . GLU A 1 98  ? 108.159 101.781 89.118  1.00 80.43  ? 98  GLU A OE2 1 
ATOM   467  N  N   . ILE A 1 99  ? 113.044 98.197  87.901  1.00 80.06  ? 99  ILE A N   1 
ATOM   468  C  CA  . ILE A 1 99  ? 114.477 98.141  88.188  1.00 80.06  ? 99  ILE A CA  1 
ATOM   469  C  C   . ILE A 1 99  ? 115.283 98.107  86.894  1.00 80.06  ? 99  ILE A C   1 
ATOM   470  O  O   . ILE A 1 99  ? 116.291 98.812  86.752  1.00 80.06  ? 99  ILE A O   1 
ATOM   471  C  CB  . ILE A 1 99  ? 114.799 96.935  89.087  1.00 80.06  ? 99  ILE A CB  1 
ATOM   472  C  CG1 . ILE A 1 99  ? 114.126 97.091  90.449  1.00 80.06  ? 99  ILE A CG1 1 
ATOM   473  C  CG2 . ILE A 1 99  ? 116.296 96.790  89.261  1.00 80.06  ? 99  ILE A CG2 1 
ATOM   474  C  CD1 . ILE A 1 99  ? 114.643 98.255  91.258  1.00 80.06  ? 99  ILE A CD1 1 
ATOM   475  N  N   . ILE A 1 100 ? 114.851 97.294  85.928  1.00 84.46  ? 100 ILE A N   1 
ATOM   476  C  CA  . ILE A 1 100 ? 115.576 97.175  84.667  1.00 84.46  ? 100 ILE A CA  1 
ATOM   477  C  C   . ILE A 1 100 ? 115.514 98.474  83.876  1.00 84.46  ? 100 ILE A C   1 
ATOM   478  O  O   . ILE A 1 100 ? 116.496 98.871  83.242  1.00 84.46  ? 100 ILE A O   1 
ATOM   479  C  CB  . ILE A 1 100 ? 115.040 95.986  83.852  1.00 84.46  ? 100 ILE A CB  1 
ATOM   480  C  CG1 . ILE A 1 100 ? 115.358 94.680  84.571  1.00 84.46  ? 100 ILE A CG1 1 
ATOM   481  C  CG2 . ILE A 1 100 ? 115.628 95.979  82.452  1.00 84.46  ? 100 ILE A CG2 1 
ATOM   482  C  CD1 . ILE A 1 100 ? 116.839 94.430  84.751  1.00 84.46  ? 100 ILE A CD1 1 
ATOM   483  N  N   . ILE A 1 101 ? 114.366 99.154  83.886  1.00 87.97  ? 101 ILE A N   1 
ATOM   484  C  CA  . ILE A 1 101 ? 114.265 100.426 83.177  1.00 87.97  ? 101 ILE A CA  1 
ATOM   485  C  C   . ILE A 1 101 ? 115.195 101.457 83.801  1.00 87.97  ? 101 ILE A C   1 
ATOM   486  O  O   . ILE A 1 101 ? 115.882 102.206 83.092  1.00 87.97  ? 101 ILE A O   1 
ATOM   487  C  CB  . ILE A 1 101 ? 112.804 100.914 83.149  1.00 87.97  ? 101 ILE A CB  1 
ATOM   488  C  CG1 . ILE A 1 101 ? 111.964 100.009 82.250  1.00 87.97  ? 101 ILE A CG1 1 
ATOM   489  C  CG2 . ILE A 1 101 ? 112.726 102.352 82.671  1.00 87.97  ? 101 ILE A CG2 1 
ATOM   490  C  CD1 . ILE A 1 101 ? 112.504 99.882  80.844  1.00 87.97  ? 101 ILE A CD1 1 
ATOM   491  N  N   . GLY A 1 102 ? 115.242 101.507 85.134  1.00 88.66  ? 102 GLY A N   1 
ATOM   492  C  CA  . GLY A 1 102 ? 116.162 102.423 85.792  1.00 88.66  ? 102 GLY A CA  1 
ATOM   493  C  C   . GLY A 1 102 ? 117.614 102.124 85.468  1.00 88.66  ? 102 GLY A C   1 
ATOM   494  O  O   . GLY A 1 102 ? 118.402 103.031 85.192  1.00 88.66  ? 102 GLY A O   1 
ATOM   495  N  N   . GLN A 1 103 ? 117.985 100.840 85.487  1.00 90.27  ? 103 GLN A N   1 
ATOM   496  C  CA  . GLN A 1 103 ? 119.364 100.456 85.204  1.00 90.27  ? 103 GLN A CA  1 
ATOM   497  C  C   . GLN A 1 103 ? 119.742 100.660 83.744  1.00 90.27  ? 103 GLN A C   1 
ATOM   498  O  O   . GLN A 1 103 ? 120.911 100.925 83.452  1.00 90.27  ? 103 GLN A O   1 
ATOM   499  C  CB  . GLN A 1 103 ? 119.595 98.995  85.592  1.00 90.27  ? 103 GLN A CB  1 
ATOM   500  C  CG  . GLN A 1 103 ? 121.059 98.589  85.629  1.00 90.27  ? 103 GLN A CG  1 
ATOM   501  C  CD  . GLN A 1 103 ? 121.256 97.138  86.020  1.00 90.27  ? 103 GLN A CD  1 
ATOM   502  O  OE1 . GLN A 1 103 ? 120.818 96.706  87.086  1.00 90.27  ? 103 GLN A OE1 1 
ATOM   503  N  NE2 . GLN A 1 103 ? 121.925 96.378  85.161  1.00 90.27  ? 103 GLN A NE2 1 
ATOM   504  N  N   . TYR A 1 104 ? 118.787 100.540 82.826  1.00 93.68  ? 104 TYR A N   1 
ATOM   505  C  CA  . TYR A 1 104 ? 119.058 100.612 81.398  1.00 93.68  ? 104 TYR A CA  1 
ATOM   506  C  C   . TYR A 1 104 ? 118.992 102.027 80.845  1.00 93.68  ? 104 TYR A C   1 
ATOM   507  O  O   . TYR A 1 104 ? 119.651 102.318 79.843  1.00 93.68  ? 104 TYR A O   1 
ATOM   508  C  CB  . TYR A 1 104 ? 118.064 99.717  80.646  1.00 93.68  ? 104 TYR A CB  1 
ATOM   509  C  CG  . TYR A 1 104 ? 118.252 99.656  79.149  1.00 93.68  ? 104 TYR A CG  1 
ATOM   510  C  CD1 . TYR A 1 104 ? 119.243 98.866  78.587  1.00 93.68  ? 104 TYR A CD1 1 
ATOM   511  C  CD2 . TYR A 1 104 ? 117.425 100.374 78.296  1.00 93.68  ? 104 TYR A CD2 1 
ATOM   512  C  CE1 . TYR A 1 104 ? 119.414 98.801  77.218  1.00 93.68  ? 104 TYR A CE1 1 
ATOM   513  C  CE2 . TYR A 1 104 ? 117.589 100.316 76.927  1.00 93.68  ? 104 TYR A CE2 1 
ATOM   514  C  CZ  . TYR A 1 104 ? 118.584 99.528  76.394  1.00 93.68  ? 104 TYR A CZ  1 
ATOM   515  O  OH  . TYR A 1 104 ? 118.750 99.467  75.030  1.00 93.68  ? 104 TYR A OH  1 
ATOM   516  N  N   . THR A 1 105 ? 118.217 102.914 81.470  1.00 94.19  ? 105 THR A N   1 
ATOM   517  C  CA  . THR A 1 105 ? 118.119 104.295 81.015  1.00 94.19  ? 105 THR A CA  1 
ATOM   518  C  C   . THR A 1 105 ? 118.971 105.263 81.824  1.00 94.19  ? 105 THR A C   1 
ATOM   519  O  O   . THR A 1 105 ? 119.283 106.350 81.323  1.00 94.19  ? 105 THR A O   1 
ATOM   520  C  CB  . THR A 1 105 ? 116.660 104.765 81.052  1.00 94.19  ? 105 THR A CB  1 
ATOM   521  O  OG1 . THR A 1 105 ? 116.150 104.636 82.385  1.00 94.19  ? 105 THR A OG1 1 
ATOM   522  C  CG2 . THR A 1 105 ? 115.811 103.939 80.105  1.00 94.19  ? 105 THR A CG2 1 
ATOM   523  N  N   . SER A 1 106 ? 119.353 104.896 83.048  1.00 95.47  ? 106 SER A N   1 
ATOM   524  C  CA  . SER A 1 106 ? 120.168 105.741 83.921  1.00 95.47  ? 106 SER A CA  1 
ATOM   525  C  C   . SER A 1 106 ? 119.507 107.098 84.156  1.00 95.47  ? 106 SER A C   1 
ATOM   526  O  O   . SER A 1 106 ? 120.143 108.151 84.073  1.00 95.47  ? 106 SER A O   1 
ATOM   527  C  CB  . SER A 1 106 ? 121.580 105.910 83.357  1.00 95.47  ? 106 SER A CB  1 
ATOM   528  O  OG  . SER A 1 106 ? 122.144 104.660 83.004  1.00 95.47  ? 106 SER A OG  1 
ATOM   529  N  N   . GLU A 1 107 ? 118.210 107.069 84.454  1.00 96.63  ? 107 GLU A N   1 
ATOM   530  C  CA  . GLU A 1 107 ? 117.442 108.279 84.712  1.00 96.63  ? 107 GLU A CA  1 
ATOM   531  C  C   . GLU A 1 107 ? 116.441 108.018 85.832  1.00 96.63  ? 107 GLU A C   1 
ATOM   532  O  O   . GLU A 1 107 ? 116.357 106.915 86.377  1.00 96.63  ? 107 GLU A O   1 
ATOM   533  C  CB  . GLU A 1 107 ? 116.737 108.768 83.441  1.00 96.63  ? 107 GLU A CB  1 
ATOM   534  C  CG  . GLU A 1 107 ? 117.648 109.520 82.480  1.00 96.63  ? 107 GLU A CG  1 
ATOM   535  C  CD  . GLU A 1 107 ? 117.923 110.952 82.908  1.00 96.63  ? 107 GLU A CD  1 
ATOM   536  O  OE1 . GLU A 1 107 ? 118.499 111.709 82.098  1.00 96.63  ? 107 GLU A OE1 1 
ATOM   537  O  OE2 . GLU A 1 107 ? 117.560 111.327 84.042  1.00 96.63  ? 107 GLU A OE2 1 
ATOM   538  N  N   . GLY A 1 108 ? 115.676 109.048 86.173  1.00 93.90  ? 108 GLY A N   1 
ATOM   539  C  CA  . GLY A 1 108 ? 114.766 109.016 87.303  1.00 93.90  ? 108 GLY A CA  1 
ATOM   540  C  C   . GLY A 1 108 ? 113.340 108.669 86.937  1.00 93.90  ? 108 GLY A C   1 
ATOM   541  O  O   . GLY A 1 108 ? 113.075 107.946 85.972  1.00 93.90  ? 108 GLY A O   1 
ATOM   542  N  N   . GLY A 1 109 ? 112.403 109.195 87.729  1.00 91.21  ? 109 GLY A N   1 
ATOM   543  C  CA  . GLY A 1 109 ? 111.007 108.815 87.572  1.00 91.21  ? 109 GLY A CA  1 
ATOM   544  C  C   . GLY A 1 109 ? 110.381 109.279 86.269  1.00 91.21  ? 109 GLY A C   1 
ATOM   545  O  O   . GLY A 1 109 ? 109.667 108.518 85.612  1.00 91.21  ? 109 GLY A O   1 
ATOM   546  N  N   . ILE A 1 110 ? 110.629 110.525 85.880  1.00 90.63  ? 110 ILE A N   1 
ATOM   547  C  CA  . ILE A 1 110 ? 109.985 111.112 84.711  1.00 90.63  ? 110 ILE A CA  1 
ATOM   548  C  C   . ILE A 1 110 ? 110.816 110.920 83.450  1.00 90.63  ? 110 ILE A C   1 
ATOM   549  O  O   . ILE A 1 110 ? 110.280 110.563 82.401  1.00 90.63  ? 110 ILE A O   1 
ATOM   550  C  CB  . ILE A 1 110 ? 109.681 112.609 84.944  1.00 90.63  ? 110 ILE A CB  1 
ATOM   551  C  CG1 . ILE A 1 110 ? 108.696 112.797 86.096  1.00 90.63  ? 110 ILE A CG1 1 
ATOM   552  C  CG2 . ILE A 1 110 ? 109.129 113.246 83.683  1.00 90.63  ? 110 ILE A CG2 1 
ATOM   553  C  CD1 . ILE A 1 110 ? 109.352 113.139 87.406  1.00 90.63  ? 110 ILE A CD1 1 
ATOM   554  N  N   . THR A 1 111 ? 112.126 111.160 83.529  1.00 92.91  ? 111 THR A N   1 
ATOM   555  C  CA  . THR A 1 111 ? 112.952 111.153 82.328  1.00 92.91  ? 111 THR A CA  1 
ATOM   556  C  C   . THR A 1 111 ? 113.169 109.743 81.787  1.00 92.91  ? 111 THR A C   1 
ATOM   557  O  O   . THR A 1 111 ? 113.504 109.586 80.608  1.00 92.91  ? 111 THR A O   1 
ATOM   558  C  CB  . THR A 1 111 ? 114.290 111.839 82.623  1.00 92.91  ? 111 THR A CB  1 
ATOM   559  O  OG1 . THR A 1 111 ? 114.040 113.151 83.140  1.00 92.91  ? 111 THR A OG1 1 
ATOM   560  C  CG2 . THR A 1 111 ? 115.113 111.994 81.353  1.00 92.91  ? 111 THR A CG2 1 
ATOM   561  N  N   . CYS A 1 112 ? 112.958 108.711 82.610  1.00 90.11  ? 112 CYS A N   1 
ATOM   562  C  CA  . CYS A 1 112 ? 113.143 107.342 82.138  1.00 90.11  ? 112 CYS A CA  1 
ATOM   563  C  C   . CYS A 1 112 ? 112.178 107.008 81.008  1.00 90.11  ? 112 CYS A C   1 
ATOM   564  O  O   . CYS A 1 112 ? 112.560 106.349 80.034  1.00 90.11  ? 112 CYS A O   1 
ATOM   565  C  CB  . CYS A 1 112 ? 112.969 106.357 83.291  1.00 90.11  ? 112 CYS A CB  1 
ATOM   566  S  SG  . CYS A 1 112 ? 111.268 106.158 83.847  1.00 90.11  ? 112 CYS A SG  1 
ATOM   567  N  N   . TRP A 1 113 ? 110.926 107.453 81.117  1.00 87.52  ? 113 TRP A N   1 
ATOM   568  C  CA  . TRP A 1 113 ? 109.939 107.194 80.077  1.00 87.52  ? 113 TRP A CA  1 
ATOM   569  C  C   . TRP A 1 113 ? 110.205 107.979 78.802  1.00 87.52  ? 113 TRP A C   1 
ATOM   570  O  O   . TRP A 1 113 ? 109.568 107.698 77.782  1.00 87.52  ? 113 TRP A O   1 
ATOM   571  C  CB  . TRP A 1 113 ? 108.536 107.509 80.594  1.00 87.52  ? 113 TRP A CB  1 
ATOM   572  C  CG  . TRP A 1 113 ? 108.140 106.647 81.742  1.00 87.52  ? 113 TRP A CG  1 
ATOM   573  C  CD1 . TRP A 1 113 ? 108.027 107.023 83.045  1.00 87.52  ? 113 TRP A CD1 1 
ATOM   574  C  CD2 . TRP A 1 113 ? 107.825 105.252 81.697  1.00 87.52  ? 113 TRP A CD2 1 
ATOM   575  N  NE1 . TRP A 1 113 ? 107.653 105.951 83.816  1.00 87.52  ? 113 TRP A NE1 1 
ATOM   576  C  CE2 . TRP A 1 113 ? 107.523 104.851 83.011  1.00 87.52  ? 113 TRP A CE2 1 
ATOM   577  C  CE3 . TRP A 1 113 ? 107.766 104.304 80.672  1.00 87.52  ? 113 TRP A CE3 1 
ATOM   578  C  CZ2 . TRP A 1 113 ? 107.168 103.544 83.329  1.00 87.52  ? 113 TRP A CZ2 1 
ATOM   579  C  CZ3 . TRP A 1 113 ? 107.412 103.007 80.988  1.00 87.52  ? 113 TRP A CZ3 1 
ATOM   580  C  CH2 . TRP A 1 113 ? 107.117 102.638 82.305  1.00 87.52  ? 113 TRP A CH2 1 
ATOM   581  N  N   . GLU A 1 114 ? 111.115 108.952 78.831  1.00 95.80  ? 114 GLU A N   1 
ATOM   582  C  CA  . GLU A 1 114 ? 111.438 109.699 77.622  1.00 95.80  ? 114 GLU A CA  1 
ATOM   583  C  C   . GLU A 1 114 ? 112.310 108.891 76.669  1.00 95.80  ? 114 GLU A C   1 
ATOM   584  O  O   . GLU A 1 114 ? 112.269 109.119 75.455  1.00 95.80  ? 114 GLU A O   1 
ATOM   585  C  CB  . GLU A 1 114 ? 112.129 111.014 77.986  1.00 95.80  ? 114 GLU A CB  1 
ATOM   586  C  CG  . GLU A 1 114 ? 111.925 112.128 76.971  1.00 95.80  ? 114 GLU A CG  1 
ATOM   587  C  CD  . GLU A 1 114 ? 112.959 112.110 75.863  1.00 95.80  ? 114 GLU A CD  1 
ATOM   588  O  OE1 . GLU A 1 114 ? 113.964 111.380 75.995  1.00 95.80  ? 114 GLU A OE1 1 
ATOM   589  O  OE2 . GLU A 1 114 ? 112.767 112.826 74.858  1.00 95.80  ? 114 GLU A OE2 1 
ATOM   590  N  N   . LYS A 1 115 ? 113.100 107.956 77.189  1.00 94.69  ? 115 LYS A N   1 
ATOM   591  C  CA  . LYS A 1 115 ? 113.935 107.096 76.361  1.00 94.69  ? 115 LYS A CA  1 
ATOM   592  C  C   . LYS A 1 115 ? 113.213 105.839 75.899  1.00 94.69  ? 115 LYS A C   1 
ATOM   593  O  O   . LYS A 1 115 ? 113.790 105.051 75.143  1.00 94.69  ? 115 LYS A O   1 
ATOM   594  C  CB  . LYS A 1 115 ? 115.210 106.712 77.119  1.00 94.69  ? 115 LYS A CB  1 
ATOM   595  C  CG  . LYS A 1 115 ? 116.235 107.829 77.198  1.00 94.69  ? 115 LYS A CG  1 
ATOM   596  C  CD  . LYS A 1 115 ? 117.448 107.417 78.011  1.00 94.69  ? 115 LYS A CD  1 
ATOM   597  C  CE  . LYS A 1 115 ? 118.524 108.490 77.971  1.00 94.69  ? 115 LYS A CE  1 
ATOM   598  N  NZ  . LYS A 1 115 ? 119.718 108.114 78.777  1.00 94.69  ? 115 LYS A NZ  1 
ATOM   599  N  N   . ILE A 1 116 ? 111.971 105.633 76.333  1.00 92.21  ? 116 ILE A N   1 
ATOM   600  C  CA  . ILE A 1 116 ? 111.159 104.492 75.921  1.00 92.21  ? 116 ILE A CA  1 
ATOM   601  C  C   . ILE A 1 116 ? 110.056 104.925 74.959  1.00 92.21  ? 116 ILE A C   1 
ATOM   602  O  O   . ILE A 1 116 ? 109.998 104.463 73.819  1.00 92.21  ? 116 ILE A O   1 
ATOM   603  C  CB  . ILE A 1 116 ? 110.574 103.759 77.148  1.00 92.21  ? 116 ILE A CB  1 
ATOM   604  C  CG1 . ILE A 1 116 ? 111.694 103.322 78.088  1.00 92.21  ? 116 ILE A CG1 1 
ATOM   605  C  CG2 . ILE A 1 116 ? 109.739 102.570 76.713  1.00 92.21  ? 116 ILE A CG2 1 
ATOM   606  C  CD1 . ILE A 1 116 ? 111.203 102.939 79.452  1.00 92.21  ? 116 ILE A CD1 1 
ATOM   607  N  N   . CYS A 1 117 ? 109.171 105.812 75.406  1.00 91.28  ? 117 CYS A N   1 
ATOM   608  C  CA  . CYS A 1 117 ? 108.104 106.358 74.580  1.00 91.28  ? 117 CYS A CA  1 
ATOM   609  C  C   . CYS A 1 117 ? 107.785 107.773 75.047  1.00 91.28  ? 117 CYS A C   1 
ATOM   610  O  O   . CYS A 1 117 ? 107.180 107.954 76.111  1.00 91.28  ? 117 CYS A O   1 
ATOM   611  C  CB  . CYS A 1 117 ? 106.857 105.475 74.644  1.00 91.28  ? 117 CYS A CB  1 
ATOM   612  S  SG  . CYS A 1 117 ? 105.542 105.953 73.501  1.00 91.28  ? 117 CYS A SG  1 
ATOM   613  N  N   . PRO A 1 118 ? 108.185 108.796 74.289  1.00 91.75  ? 118 PRO A N   1 
ATOM   614  C  CA  . PRO A 1 118 ? 107.922 110.178 74.726  1.00 91.75  ? 118 PRO A CA  1 
ATOM   615  C  C   . PRO A 1 118 ? 106.446 110.509 74.866  1.00 91.75  ? 118 PRO A C   1 
ATOM   616  O  O   . PRO A 1 118 ? 106.098 111.418 75.630  1.00 91.75  ? 118 PRO A O   1 
ATOM   617  C  CB  . PRO A 1 118 ? 108.586 111.021 73.628  1.00 91.75  ? 118 PRO A CB  1 
ATOM   618  C  CG  . PRO A 1 118 ? 109.595 110.115 73.007  1.00 91.75  ? 118 PRO A CG  1 
ATOM   619  C  CD  . PRO A 1 118 ? 108.996 108.747 73.064  1.00 91.75  ? 118 PRO A CD  1 
ATOM   620  N  N   . LEU A 1 119 ? 105.566 109.803 74.153  1.00 87.69  ? 119 LEU A N   1 
ATOM   621  C  CA  . LEU A 1 119 ? 104.141 110.115 74.211  1.00 87.69  ? 119 LEU A CA  1 
ATOM   622  C  C   . LEU A 1 119 ? 103.534 109.774 75.566  1.00 87.69  ? 119 LEU A C   1 
ATOM   623  O  O   . LEU A 1 119 ? 102.569 110.420 75.989  1.00 87.69  ? 119 LEU A O   1 
ATOM   624  C  CB  . LEU A 1 119 ? 103.399 109.371 73.101  1.00 87.69  ? 119 LEU A CB  1 
ATOM   625  C  CG  . LEU A 1 119 ? 101.915 109.691 72.919  1.00 87.69  ? 119 LEU A CG  1 
ATOM   626  C  CD1 . LEU A 1 119 ? 101.736 111.086 72.348  1.00 87.69  ? 119 LEU A CD1 1 
ATOM   627  C  CD2 . LEU A 1 119 ? 101.247 108.653 72.034  1.00 87.69  ? 119 LEU A CD2 1 
ATOM   628  N  N   . PHE A 1 120 ? 104.076 108.777 76.259  1.00 83.74  ? 120 PHE A N   1 
ATOM   629  C  CA  . PHE A 1 120 ? 103.516 108.289 77.514  1.00 83.74  ? 120 PHE A CA  1 
ATOM   630  C  C   . PHE A 1 120 ? 104.329 108.756 78.718  1.00 83.74  ? 120 PHE A C   1 
ATOM   631  O  O   . PHE A 1 120 ? 104.502 108.022 79.692  1.00 83.74  ? 120 PHE A O   1 
ATOM   632  C  CB  . PHE A 1 120 ? 103.411 106.768 77.501  1.00 83.74  ? 120 PHE A CB  1 
ATOM   633  C  CG  . PHE A 1 120 ? 102.265 106.248 76.683  1.00 83.74  ? 120 PHE A CG  1 
ATOM   634  C  CD1 . PHE A 1 120 ? 102.336 106.229 75.301  1.00 83.74  ? 120 PHE A CD1 1 
ATOM   635  C  CD2 . PHE A 1 120 ? 101.116 105.783 77.297  1.00 83.74  ? 120 PHE A CD2 1 
ATOM   636  C  CE1 . PHE A 1 120 ? 101.285 105.754 74.547  1.00 83.74  ? 120 PHE A CE1 1 
ATOM   637  C  CE2 . PHE A 1 120 ? 100.060 105.307 76.547  1.00 83.74  ? 120 PHE A CE2 1 
ATOM   638  C  CZ  . PHE A 1 120 ? 100.145 105.293 75.170  1.00 83.74  ? 120 PHE A CZ  1 
ATOM   639  N  N   . SER A 1 121 ? 104.832 109.990 78.665  1.00 84.84  ? 121 SER A N   1 
ATOM   640  C  CA  . SER A 1 121 ? 105.595 110.542 79.778  1.00 84.84  ? 121 SER A CA  1 
ATOM   641  C  C   . SER A 1 121 ? 104.728 110.884 80.981  1.00 84.84  ? 121 SER A C   1 
ATOM   642  O  O   . SER A 1 121 ? 105.275 111.185 82.047  1.00 84.84  ? 121 SER A O   1 
ATOM   643  C  CB  . SER A 1 121 ? 106.355 111.788 79.326  1.00 84.84  ? 121 SER A CB  1 
ATOM   644  O  OG  . SER A 1 121 ? 106.985 111.573 78.077  1.00 84.84  ? 121 SER A OG  1 
ATOM   645  N  N   . GLY A 1 122 ? 103.401 110.842 80.843  1.00 78.51  ? 122 GLY A N   1 
ATOM   646  C  CA  . GLY A 1 122 ? 102.520 111.215 81.935  1.00 78.51  ? 122 GLY A CA  1 
ATOM   647  C  C   . GLY A 1 122 ? 102.494 110.227 83.078  1.00 78.51  ? 122 GLY A C   1 
ATOM   648  O  O   . GLY A 1 122 ? 101.999 110.561 84.159  1.00 78.51  ? 122 GLY A O   1 
ATOM   649  N  N   . ILE A 1 123 ? 103.013 109.017 82.866  1.00 78.31  ? 123 ILE A N   1 
ATOM   650  C  CA  . ILE A 1 123 ? 103.097 108.048 83.954  1.00 78.31  ? 123 ILE A CA  1 
ATOM   651  C  C   . ILE A 1 123 ? 104.002 108.573 85.060  1.00 78.31  ? 123 ILE A C   1 
ATOM   652  O  O   . ILE A 1 123 ? 103.713 108.407 86.252  1.00 78.31  ? 123 ILE A O   1 
ATOM   653  C  CB  . ILE A 1 123 ? 103.578 106.687 83.418  1.00 78.31  ? 123 ILE A CB  1 
ATOM   654  C  CG1 . ILE A 1 123 ? 102.881 106.365 82.095  1.00 78.31  ? 123 ILE A CG1 1 
ATOM   655  C  CG2 . ILE A 1 123 ? 103.324 105.592 84.438  1.00 78.31  ? 123 ILE A CG2 1 
ATOM   656  C  CD1 . ILE A 1 123 ? 103.321 105.065 81.472  1.00 78.31  ? 123 ILE A CD1 1 
ATOM   657  N  N   . GLY A 1 124 ? 105.100 109.232 84.686  1.00 78.24  ? 124 GLY A N   1 
ATOM   658  C  CA  . GLY A 1 124 ? 105.981 109.810 85.688  1.00 78.24  ? 124 GLY A CA  1 
ATOM   659  C  C   . GLY A 1 124 ? 105.311 110.904 86.497  1.00 78.24  ? 124 GLY A C   1 
ATOM   660  O  O   . GLY A 1 124 ? 105.431 110.949 87.724  1.00 78.24  ? 124 GLY A O   1 
ATOM   661  N  N   . TYR A 1 125 ? 104.595 111.805 85.819  1.00 80.05  ? 125 TYR A N   1 
ATOM   662  C  CA  . TYR A 1 125 ? 103.906 112.885 86.521  1.00 80.05  ? 125 TYR A CA  1 
ATOM   663  C  C   . TYR A 1 125 ? 102.815 112.343 87.435  1.00 80.05  ? 125 TYR A C   1 
ATOM   664  O  O   . TYR A 1 125 ? 102.625 112.839 88.554  1.00 80.05  ? 125 TYR A O   1 
ATOM   665  C  CB  . TYR A 1 125 ? 103.323 113.874 85.517  1.00 80.05  ? 125 TYR A CB  1 
ATOM   666  C  CG  . TYR A 1 125 ? 104.365 114.661 84.761  1.00 80.05  ? 125 TYR A CG  1 
ATOM   667  C  CD1 . TYR A 1 125 ? 105.149 115.606 85.404  1.00 80.05  ? 125 TYR A CD1 1 
ATOM   668  C  CD2 . TYR A 1 125 ? 104.565 114.459 83.406  1.00 80.05  ? 125 TYR A CD2 1 
ATOM   669  C  CE1 . TYR A 1 125 ? 106.103 116.328 84.717  1.00 80.05  ? 125 TYR A CE1 1 
ATOM   670  C  CE2 . TYR A 1 125 ? 105.516 115.174 82.710  1.00 80.05  ? 125 TYR A CE2 1 
ATOM   671  C  CZ  . TYR A 1 125 ? 106.282 116.108 83.370  1.00 80.05  ? 125 TYR A CZ  1 
ATOM   672  O  OH  . TYR A 1 125 ? 107.231 116.822 82.679  1.00 80.05  ? 125 TYR A OH  1 
ATOM   673  N  N   . ALA A 1 126 ? 102.080 111.329 86.973  1.00 73.85  ? 126 ALA A N   1 
ATOM   674  C  CA  . ALA A 1 126 ? 101.079 110.701 87.824  1.00 73.85  ? 126 ALA A CA  1 
ATOM   675  C  C   . ALA A 1 126 ? 101.724 110.063 89.045  1.00 73.85  ? 126 ALA A C   1 
ATOM   676  O  O   . ALA A 1 126 ? 101.196 110.163 90.160  1.00 73.85  ? 126 ALA A O   1 
ATOM   677  C  CB  . ALA A 1 126 ? 100.290 109.664 87.026  1.00 73.85  ? 126 ALA A CB  1 
ATOM   678  N  N   . SER A 1 127 ? 102.874 109.411 88.858  1.00 72.71  ? 127 SER A N   1 
ATOM   679  C  CA  . SER A 1 127 ? 103.587 108.831 89.990  1.00 72.71  ? 127 SER A CA  1 
ATOM   680  C  C   . SER A 1 127 ? 104.029 109.907 90.973  1.00 72.71  ? 127 SER A C   1 
ATOM   681  O  O   . SER A 1 127 ? 103.981 109.703 92.190  1.00 72.71  ? 127 SER A O   1 
ATOM   682  C  CB  . SER A 1 127 ? 104.789 108.028 89.496  1.00 72.71  ? 127 SER A CB  1 
ATOM   683  O  OG  . SER A 1 127 ? 104.379 106.835 88.854  1.00 72.71  ? 127 SER A OG  1 
ATOM   684  N  N   . VAL A 1 128 ? 104.470 111.059 90.463  1.00 71.03  ? 128 VAL A N   1 
ATOM   685  C  CA  . VAL A 1 128 ? 104.910 112.137 91.345  1.00 71.03  ? 128 VAL A CA  1 
ATOM   686  C  C   . VAL A 1 128 ? 103.738 112.695 92.145  1.00 71.03  ? 128 VAL A C   1 
ATOM   687  O  O   . VAL A 1 128 ? 103.864 112.967 93.344  1.00 71.03  ? 128 VAL A O   1 
ATOM   688  C  CB  . VAL A 1 128 ? 105.626 113.237 90.542  1.00 71.03  ? 128 VAL A CB  1 
ATOM   689  C  CG1 . VAL A 1 128 ? 105.975 114.397 91.446  1.00 71.03  ? 128 VAL A CG1 1 
ATOM   690  C  CG2 . VAL A 1 128 ? 106.883 112.684 89.914  1.00 71.03  ? 128 VAL A CG2 1 
ATOM   691  N  N   . VAL A 1 129 ? 102.581 112.872 91.505  1.00 69.40  ? 129 VAL A N   1 
ATOM   692  C  CA  . VAL A 1 129 ? 101.403 113.342 92.236  1.00 69.40  ? 129 VAL A CA  1 
ATOM   693  C  C   . VAL A 1 129 ? 101.001 112.332 93.306  1.00 69.40  ? 129 VAL A C   1 
ATOM   694  O  O   . VAL A 1 129 ? 100.682 112.699 94.449  1.00 69.40  ? 129 VAL A O   1 
ATOM   695  C  CB  . VAL A 1 129 ? 100.245 113.627 91.261  1.00 69.40  ? 129 VAL A CB  1 
ATOM   696  C  CG1 . VAL A 1 129 ? 98.987  113.991 92.024  1.00 69.40  ? 129 VAL A CG1 1 
ATOM   697  C  CG2 . VAL A 1 129 ? 100.624 114.736 90.301  1.00 69.40  ? 129 VAL A CG2 1 
ATOM   698  N  N   . ILE A 1 130 ? 101.020 111.043 92.955  1.00 67.78  ? 130 ILE A N   1 
ATOM   699  C  CA  . ILE A 1 130 ? 100.662 109.999 93.910  1.00 67.78  ? 130 ILE A CA  1 
ATOM   700  C  C   . ILE A 1 130 ? 101.612 110.009 95.099  1.00 67.78  ? 130 ILE A C   1 
ATOM   701  O  O   . ILE A 1 130 ? 101.181 109.928 96.255  1.00 67.78  ? 130 ILE A O   1 
ATOM   702  C  CB  . ILE A 1 130 ? 100.648 108.625 93.214  1.00 67.78  ? 130 ILE A CB  1 
ATOM   703  C  CG1 . ILE A 1 130 ? 99.485  108.531 92.228  1.00 67.78  ? 130 ILE A CG1 1 
ATOM   704  C  CG2 . ILE A 1 130 ? 100.554 107.511 94.234  1.00 67.78  ? 130 ILE A CG2 1 
ATOM   705  C  CD1 . ILE A 1 130 ? 99.377  107.188 91.549  1.00 67.78  ? 130 ILE A CD1 1 
ATOM   706  N  N   . VAL A 1 131 ? 102.919 110.115 94.841  1.00 67.08  ? 131 VAL A N   1 
ATOM   707  C  CA  . VAL A 1 131 ? 103.881 110.064 95.938  1.00 67.08  ? 131 VAL A CA  1 
ATOM   708  C  C   . VAL A 1 131 ? 103.815 111.339 96.771  1.00 67.08  ? 131 VAL A C   1 
ATOM   709  O  O   . VAL A 1 131 ? 104.073 111.304 97.975  1.00 67.08  ? 131 VAL A O   1 
ATOM   710  C  CB  . VAL A 1 131 ? 105.308 109.789 95.418  1.00 67.08  ? 131 VAL A CB  1 
ATOM   711  C  CG1 . VAL A 1 131 ? 105.829 110.937 94.585  1.00 67.08  ? 131 VAL A CG1 1 
ATOM   712  C  CG2 . VAL A 1 131 ? 106.251 109.479 96.568  1.00 67.08  ? 131 VAL A CG2 1 
ATOM   713  N  N   . SER A 1 132 ? 103.452 112.474 96.169  1.00 68.01  ? 132 SER A N   1 
ATOM   714  C  CA  . SER A 1 132 ? 103.270 113.695 96.950  1.00 68.01  ? 132 SER A CA  1 
ATOM   715  C  C   . SER A 1 132 ? 102.104 113.556 97.922  1.00 68.01  ? 132 SER A C   1 
ATOM   716  O  O   . SER A 1 132 ? 102.224 113.880 99.112  1.00 68.01  ? 132 SER A O   1 
ATOM   717  C  CB  . SER A 1 132 ? 103.056 114.886 96.019  1.00 68.01  ? 132 SER A CB  1 
ATOM   718  O  OG  . SER A 1 132 ? 104.129 115.016 95.107  1.00 68.01  ? 132 SER A OG  1 
ATOM   719  N  N   . LEU A 1 133 ? 100.963 113.060 97.436  1.00 65.04  ? 133 LEU A N   1 
ATOM   720  C  CA  . LEU A 1 133 ? 99.827  112.847 98.331  1.00 65.04  ? 133 LEU A CA  1 
ATOM   721  C  C   . LEU A 1 133 ? 100.157 111.810 99.401  1.00 65.04  ? 133 LEU A C   1 
ATOM   722  O  O   . LEU A 1 133 ? 99.765  111.957 100.570 1.00 65.04  ? 133 LEU A O   1 
ATOM   723  C  CB  . LEU A 1 133 ? 98.598  112.426 97.528  1.00 65.04  ? 133 LEU A CB  1 
ATOM   724  C  CG  . LEU A 1 133 ? 98.097  113.441 96.500  1.00 65.04  ? 133 LEU A CG  1 
ATOM   725  C  CD1 . LEU A 1 133 ? 96.914  112.886 95.730  1.00 65.04  ? 133 LEU A CD1 1 
ATOM   726  C  CD2 . LEU A 1 133 ? 97.733  114.754 97.171  1.00 65.04  ? 133 LEU A CD2 1 
ATOM   727  N  N   . LEU A 1 134 ? 100.878 110.754 99.018  1.00 62.21  ? 134 LEU A N   1 
ATOM   728  C  CA  . LEU A 1 134 ? 101.282 109.733 99.976  1.00 62.21  ? 134 LEU A CA  1 
ATOM   729  C  C   . LEU A 1 134 ? 102.206 110.306 101.040 1.00 62.21  ? 134 LEU A C   1 
ATOM   730  O  O   . LEU A 1 134 ? 102.076 109.978 102.221 1.00 62.21  ? 134 LEU A O   1 
ATOM   731  C  CB  . LEU A 1 134 ? 101.957 108.573 99.247  1.00 62.21  ? 134 LEU A CB  1 
ATOM   732  C  CG  . LEU A 1 134 ? 102.621 107.503 100.112 1.00 62.21  ? 134 LEU A CG  1 
ATOM   733  C  CD1 . LEU A 1 134 ? 101.588 106.612 100.774 1.00 62.21  ? 134 LEU A CD1 1 
ATOM   734  C  CD2 . LEU A 1 134 ? 103.586 106.687 99.279  1.00 62.21  ? 134 LEU A CD2 1 
ATOM   735  N  N   . ASN A 1 135 ? 103.153 111.158 100.642 1.00 67.02  ? 135 ASN A N   1 
ATOM   736  C  CA  . ASN A 1 135 ? 104.021 111.812 101.613 1.00 67.02  ? 135 ASN A CA  1 
ATOM   737  C  C   . ASN A 1 135 ? 103.213 112.696 102.546 1.00 67.02  ? 135 ASN A C   1 
ATOM   738  O  O   . ASN A 1 135 ? 103.527 112.808 103.736 1.00 67.02  ? 135 ASN A O   1 
ATOM   739  C  CB  . ASN A 1 135 ? 105.090 112.638 100.898 1.00 67.02  ? 135 ASN A CB  1 
ATOM   740  C  CG  . ASN A 1 135 ? 106.163 111.782 100.264 1.00 67.02  ? 135 ASN A CG  1 
ATOM   741  O  OD1 . ASN A 1 135 ? 106.302 110.603 100.584 1.00 67.02  ? 135 ASN A OD1 1 
ATOM   742  N  ND2 . ASN A 1 135 ? 106.931 112.374 99.357  1.00 67.02  ? 135 ASN A ND2 1 
ATOM   743  N  N   . VAL A 1 136 ? 102.167 113.336 102.022 1.00 64.10  ? 136 VAL A N   1 
ATOM   744  C  CA  . VAL A 1 136 ? 101.331 114.185 102.864 1.00 64.10  ? 136 VAL A CA  1 
ATOM   745  C  C   . VAL A 1 136 ? 100.641 113.358 103.944 1.00 64.10  ? 136 VAL A C   1 
ATOM   746  O  O   . VAL A 1 136 ? 100.700 113.697 105.131 1.00 64.10  ? 136 VAL A O   1 
ATOM   747  C  CB  . VAL A 1 136 ? 100.315 114.966 102.013 1.00 64.10  ? 136 VAL A CB  1 
ATOM   748  C  CG1 . VAL A 1 136 ? 99.175  115.468 102.881 1.00 64.10  ? 136 VAL A CG1 1 
ATOM   749  C  CG2 . VAL A 1 136 ? 100.995 116.127 101.317 1.00 64.10  ? 136 VAL A CG2 1 
ATOM   750  N  N   . TYR A 1 137 ? 99.981  112.257 103.564 1.00 64.13  ? 137 TYR A N   1 
ATOM   751  C  CA  . TYR A 1 137 ? 99.183  111.600 104.602 1.00 64.13  ? 137 TYR A CA  1 
ATOM   752  C  C   . TYR A 1 137 ? 99.915  110.462 105.305 1.00 64.13  ? 137 TYR A C   1 
ATOM   753  O  O   . TYR A 1 137 ? 99.360  109.883 106.244 1.00 64.13  ? 137 TYR A O   1 
ATOM   754  C  CB  . TYR A 1 137 ? 97.850  111.035 104.079 1.00 64.13  ? 137 TYR A CB  1 
ATOM   755  C  CG  . TYR A 1 137 ? 97.910  109.834 103.158 1.00 64.13  ? 137 TYR A CG  1 
ATOM   756  C  CD1 . TYR A 1 137 ? 97.996  109.969 101.786 1.00 64.13  ? 137 TYR A CD1 1 
ATOM   757  C  CD2 . TYR A 1 137 ? 97.841  108.549 103.684 1.00 64.13  ? 137 TYR A CD2 1 
ATOM   758  C  CE1 . TYR A 1 137 ? 98.031  108.857 100.965 1.00 64.13  ? 137 TYR A CE1 1 
ATOM   759  C  CE2 . TYR A 1 137 ? 97.879  107.440 102.877 1.00 64.13  ? 137 TYR A CE2 1 
ATOM   760  C  CZ  . TYR A 1 137 ? 97.974  107.596 101.520 1.00 64.13  ? 137 TYR A CZ  1 
ATOM   761  O  OH  . TYR A 1 137 ? 98.010  106.482 100.717 1.00 64.13  ? 137 TYR A OH  1 
ATOM   762  N  N   . TYR A 1 138 ? 101.137 110.130 104.890 1.00 67.38  ? 138 TYR A N   1 
ATOM   763  C  CA  . TYR A 1 138 ? 101.830 108.957 105.402 1.00 67.38  ? 138 TYR A CA  1 
ATOM   764  C  C   . TYR A 1 138 ? 102.595 109.242 106.684 1.00 67.38  ? 138 TYR A C   1 
ATOM   765  O  O   . TYR A 1 138 ? 102.888 108.309 107.438 1.00 67.38  ? 138 TYR A O   1 
ATOM   766  C  CB  . TYR A 1 138 ? 102.778 108.441 104.314 1.00 67.38  ? 138 TYR A CB  1 
ATOM   767  C  CG  . TYR A 1 138 ? 103.528 107.168 104.630 1.00 67.38  ? 138 TYR A CG  1 
ATOM   768  C  CD1 . TYR A 1 138 ? 102.894 105.935 104.598 1.00 67.38  ? 138 TYR A CD1 1 
ATOM   769  C  CD2 . TYR A 1 138 ? 104.881 107.200 104.931 1.00 67.38  ? 138 TYR A CD2 1 
ATOM   770  C  CE1 . TYR A 1 138 ? 103.584 104.771 104.876 1.00 67.38  ? 138 TYR A CE1 1 
ATOM   771  C  CE2 . TYR A 1 138 ? 105.577 106.045 105.211 1.00 67.38  ? 138 TYR A CE2 1 
ATOM   772  C  CZ  . TYR A 1 138 ? 104.926 104.834 105.180 1.00 67.38  ? 138 TYR A CZ  1 
ATOM   773  O  OH  . TYR A 1 138 ? 105.624 103.684 105.459 1.00 67.38  ? 138 TYR A OH  1 
ATOM   774  N  N   . ILE A 1 139 ? 102.914 110.511 106.946 1.00 66.42  ? 139 ILE A N   1 
ATOM   775  C  CA  . ILE A 1 139 ? 103.655 110.894 108.141 1.00 66.42  ? 139 ILE A CA  1 
ATOM   776  C  C   . ILE A 1 139 ? 102.748 111.115 109.345 1.00 66.42  ? 139 ILE A C   1 
ATOM   777  O  O   . ILE A 1 139 ? 103.245 111.232 110.475 1.00 66.42  ? 139 ILE A O   1 
ATOM   778  C  CB  . ILE A 1 139 ? 104.493 112.147 107.824 1.00 66.42  ? 139 ILE A CB  1 
ATOM   779  C  CG1 . ILE A 1 139 ? 105.666 112.286 108.793 1.00 66.42  ? 139 ILE A CG1 1 
ATOM   780  C  CG2 . ILE A 1 139 ? 103.616 113.382 107.829 1.00 66.42  ? 139 ILE A CG2 1 
ATOM   781  C  CD1 . ILE A 1 139 ? 106.786 113.145 108.256 1.00 66.42  ? 139 ILE A CD1 1 
ATOM   782  N  N   . VAL A 1 140 ? 101.429 111.161 109.146 1.00 65.73  ? 140 VAL A N   1 
ATOM   783  C  CA  . VAL A 1 140 ? 100.514 111.245 110.281 1.00 65.73  ? 140 VAL A CA  1 
ATOM   784  C  C   . VAL A 1 140 ? 100.561 109.962 111.102 1.00 65.73  ? 140 VAL A C   1 
ATOM   785  O  O   . VAL A 1 140 ? 100.372 109.989 112.325 1.00 65.73  ? 140 VAL A O   1 
ATOM   786  C  CB  . VAL A 1 140 ? 99.090  111.565 109.792 1.00 65.73  ? 140 VAL A CB  1 
ATOM   787  C  CG1 . VAL A 1 140 ? 98.166  111.822 110.965 1.00 65.73  ? 140 VAL A CG1 1 
ATOM   788  C  CG2 . VAL A 1 140 ? 99.111  112.766 108.864 1.00 65.73  ? 140 VAL A CG2 1 
ATOM   789  N  N   . ILE A 1 141 ? 100.815 108.825 110.454 1.00 65.49  ? 141 ILE A N   1 
ATOM   790  C  CA  . ILE A 1 141 ? 101.011 107.578 111.188 1.00 65.49  ? 141 ILE A CA  1 
ATOM   791  C  C   . ILE A 1 141 ? 102.218 107.696 112.110 1.00 65.49  ? 141 ILE A C   1 
ATOM   792  O  O   . ILE A 1 141 ? 102.179 107.273 113.271 1.00 65.49  ? 141 ILE A O   1 
ATOM   793  C  CB  . ILE A 1 141 ? 101.163 106.401 110.209 1.00 65.49  ? 141 ILE A CB  1 
ATOM   794  C  CG1 . ILE A 1 141 ? 100.034 106.412 109.181 1.00 65.49  ? 141 ILE A CG1 1 
ATOM   795  C  CG2 . ILE A 1 141 ? 101.174 105.079 110.960 1.00 65.49  ? 141 ILE A CG2 1 
ATOM   796  C  CD1 . ILE A 1 141 ? 100.317 105.560 107.976 1.00 65.49  ? 141 ILE A CD1 1 
ATOM   797  N  N   . LEU A 1 142 ? 103.308 108.279 111.607 1.00 64.51  ? 142 LEU A N   1 
ATOM   798  C  CA  . LEU A 1 142 ? 104.485 108.510 112.436 1.00 64.51  ? 142 LEU A CA  1 
ATOM   799  C  C   . LEU A 1 142 ? 104.200 109.506 113.553 1.00 64.51  ? 142 LEU A C   1 
ATOM   800  O  O   . LEU A 1 142 ? 104.759 109.383 114.646 1.00 64.51  ? 142 LEU A O   1 
ATOM   801  C  CB  . LEU A 1 142 ? 105.646 108.998 111.571 1.00 64.51  ? 142 LEU A CB  1 
ATOM   802  C  CG  . LEU A 1 142 ? 106.127 108.034 110.486 1.00 64.51  ? 142 LEU A CG  1 
ATOM   803  C  CD1 . LEU A 1 142 ? 107.176 108.693 109.612 1.00 64.51  ? 142 LEU A CD1 1 
ATOM   804  C  CD2 . LEU A 1 142 ? 106.667 106.759 111.105 1.00 64.51  ? 142 LEU A CD2 1 
ATOM   805  N  N   . ALA A 1 143 ? 103.355 110.505 113.291 1.00 65.71  ? 143 ALA A N   1 
ATOM   806  C  CA  . ALA A 1 143 ? 102.959 111.436 114.345 1.00 65.71  ? 143 ALA A CA  1 
ATOM   807  C  C   . ALA A 1 143 ? 102.208 110.720 115.465 1.00 65.71  ? 143 ALA A C   1 
ATOM   808  O  O   . ALA A 1 143 ? 102.465 110.961 116.650 1.00 65.71  ? 143 ALA A O   1 
ATOM   809  C  CB  . ALA A 1 143 ? 102.109 112.561 113.761 1.00 65.71  ? 143 ALA A CB  1 
ATOM   810  N  N   . TRP A 1 144 ? 101.278 109.831 115.111 1.00 67.29  ? 144 TRP A N   1 
ATOM   811  C  CA  . TRP A 1 144 ? 100.601 109.037 116.134 1.00 67.29  ? 144 TRP A CA  1 
ATOM   812  C  C   . TRP A 1 144 ? 101.589 108.137 116.869 1.00 67.29  ? 144 TRP A C   1 
ATOM   813  O  O   . TRP A 1 144 ? 101.488 107.947 118.089 1.00 67.29  ? 144 TRP A O   1 
ATOM   814  C  CB  . TRP A 1 144 ? 99.484  108.196 115.514 1.00 67.29  ? 144 TRP A CB  1 
ATOM   815  C  CG  . TRP A 1 144 ? 98.440  108.975 114.771 1.00 67.29  ? 144 TRP A CG  1 
ATOM   816  C  CD1 . TRP A 1 144 ? 98.093  110.280 114.963 1.00 67.29  ? 144 TRP A CD1 1 
ATOM   817  C  CD2 . TRP A 1 144 ? 97.601  108.489 113.717 1.00 67.29  ? 144 TRP A CD2 1 
ATOM   818  N  NE1 . TRP A 1 144 ? 97.095  110.638 114.091 1.00 67.29  ? 144 TRP A NE1 1 
ATOM   819  C  CE2 . TRP A 1 144 ? 96.775  109.556 113.315 1.00 67.29  ? 144 TRP A CE2 1 
ATOM   820  C  CE3 . TRP A 1 144 ? 97.471  107.255 113.072 1.00 67.29  ? 144 TRP A CE3 1 
ATOM   821  C  CZ2 . TRP A 1 144 ? 95.832  109.427 112.299 1.00 67.29  ? 144 TRP A CZ2 1 
ATOM   822  C  CZ3 . TRP A 1 144 ? 96.536  107.129 112.065 1.00 67.29  ? 144 TRP A CZ3 1 
ATOM   823  C  CH2 . TRP A 1 144 ? 95.728  108.208 111.688 1.00 67.29  ? 144 TRP A CH2 1 
ATOM   824  N  N   . ALA A 1 145 ? 102.549 107.567 116.135 1.00 66.62  ? 145 ALA A N   1 
ATOM   825  C  CA  . ALA A 1 145 ? 103.541 106.690 116.749 1.00 66.62  ? 145 ALA A CA  1 
ATOM   826  C  C   . ALA A 1 145 ? 104.399 107.440 117.760 1.00 66.62  ? 145 ALA A C   1 
ATOM   827  O  O   . ALA A 1 145 ? 104.677 106.929 118.848 1.00 66.62  ? 145 ALA A O   1 
ATOM   828  C  CB  . ALA A 1 145 ? 104.414 106.053 115.671 1.00 66.62  ? 145 ALA A CB  1 
ATOM   829  N  N   . THR A 1 146 ? 104.827 108.658 117.423 1.00 65.87  ? 146 THR A N   1 
ATOM   830  C  CA  . THR A 1 146 ? 105.643 109.425 118.360 1.00 65.87  ? 146 THR A CA  1 
ATOM   831  C  C   . THR A 1 146 ? 104.810 109.977 119.511 1.00 65.87  ? 146 THR A C   1 
ATOM   832  O  O   . THR A 1 146 ? 105.334 110.155 120.617 1.00 65.87  ? 146 THR A O   1 
ATOM   833  C  CB  . THR A 1 146 ? 106.393 110.546 117.635 1.00 65.87  ? 146 THR A CB  1 
ATOM   834  O  OG1 . THR A 1 146 ? 107.258 111.217 118.557 1.00 65.87  ? 146 THR A OG1 1 
ATOM   835  C  CG2 . THR A 1 146 ? 105.446 111.546 117.038 1.00 65.87  ? 146 THR A CG2 1 
ATOM   836  N  N   . TYR A 1 147 ? 103.515 110.221 119.293 1.00 63.57  ? 147 TYR A N   1 
ATOM   837  C  CA  . TYR A 1 147 ? 102.637 110.552 120.412 1.00 63.57  ? 147 TYR A CA  1 
ATOM   838  C  C   . TYR A 1 147 ? 102.566 109.394 121.402 1.00 63.57  ? 147 TYR A C   1 
ATOM   839  O  O   . TYR A 1 147 ? 102.676 109.590 122.619 1.00 63.57  ? 147 TYR A O   1 
ATOM   840  C  CB  . TYR A 1 147 ? 101.244 110.917 119.894 1.00 63.57  ? 147 TYR A CB  1 
ATOM   841  C  CG  . TYR A 1 147 ? 100.251 111.297 120.974 1.00 63.57  ? 147 TYR A CG  1 
ATOM   842  C  CD1 . TYR A 1 147 ? 99.444  110.339 121.572 1.00 63.57  ? 147 TYR A CD1 1 
ATOM   843  C  CD2 . TYR A 1 147 ? 100.115 112.615 121.387 1.00 63.57  ? 147 TYR A CD2 1 
ATOM   844  C  CE1 . TYR A 1 147 ? 98.539  110.679 122.554 1.00 63.57  ? 147 TYR A CE1 1 
ATOM   845  C  CE2 . TYR A 1 147 ? 99.210  112.963 122.370 1.00 63.57  ? 147 TYR A CE2 1 
ATOM   846  C  CZ  . TYR A 1 147 ? 98.426  111.991 122.949 1.00 63.57  ? 147 TYR A CZ  1 
ATOM   847  O  OH  . TYR A 1 147 ? 97.521  112.328 123.928 1.00 63.57  ? 147 TYR A OH  1 
ATOM   848  N  N   . TYR A 1 148 ? 102.403 108.171 120.891 1.00 66.52  ? 148 TYR A N   1 
ATOM   849  C  CA  . TYR A 1 148 ? 102.431 106.998 121.764 1.00 66.52  ? 148 TYR A CA  1 
ATOM   850  C  C   . TYR A 1 148 ? 103.790 106.817 122.429 1.00 66.52  ? 148 TYR A C   1 
ATOM   851  O  O   . TYR A 1 148 ? 103.867 106.399 123.589 1.00 66.52  ? 148 TYR A O   1 
ATOM   852  C  CB  . TYR A 1 148 ? 102.052 105.740 120.986 1.00 66.52  ? 148 TYR A CB  1 
ATOM   853  C  CG  . TYR A 1 148 ? 100.572 105.562 120.745 1.00 66.52  ? 148 TYR A CG  1 
ATOM   854  C  CD1 . TYR A 1 148 ? 99.639  106.276 121.473 1.00 66.52  ? 148 TYR A CD1 1 
ATOM   855  C  CD2 . TYR A 1 148 ? 100.111 104.661 119.803 1.00 66.52  ? 148 TYR A CD2 1 
ATOM   856  C  CE1 . TYR A 1 148 ? 98.290  106.102 121.259 1.00 66.52  ? 148 TYR A CE1 1 
ATOM   857  C  CE2 . TYR A 1 148 ? 98.766  104.485 119.586 1.00 66.52  ? 148 TYR A CE2 1 
ATOM   858  C  CZ  . TYR A 1 148 ? 97.861  105.207 120.313 1.00 66.52  ? 148 TYR A CZ  1 
ATOM   859  O  OH  . TYR A 1 148 ? 96.518  105.026 120.091 1.00 66.52  ? 148 TYR A OH  1 
ATOM   860  N  N   . LEU A 1 149 ? 104.873 107.098 121.705 1.00 69.14  ? 149 LEU A N   1 
ATOM   861  C  CA  . LEU A 1 149 ? 106.202 106.973 122.295 1.00 69.14  ? 149 LEU A CA  1 
ATOM   862  C  C   . LEU A 1 149 ? 106.374 107.928 123.468 1.00 69.14  ? 149 LEU A C   1 
ATOM   863  O  O   . LEU A 1 149 ? 106.871 107.535 124.530 1.00 69.14  ? 149 LEU A O   1 
ATOM   864  C  CB  . LEU A 1 149 ? 107.275 107.224 121.237 1.00 69.14  ? 149 LEU A CB  1 
ATOM   865  C  CG  . LEU A 1 149 ? 108.725 107.172 121.722 1.00 69.14  ? 149 LEU A CG  1 
ATOM   866  C  CD1 . LEU A 1 149 ? 109.043 105.816 122.325 1.00 69.14  ? 149 LEU A CD1 1 
ATOM   867  C  CD2 . LEU A 1 149 ? 109.683 107.495 120.590 1.00 69.14  ? 149 LEU A CD2 1 
ATOM   868  N  N   . PHE A 1 150 ? 105.958 109.186 123.299 1.00 71.76  ? 150 PHE A N   1 
ATOM   869  C  CA  . PHE A 1 150 ? 106.037 110.145 124.397 1.00 71.76  ? 150 PHE A CA  1 
ATOM   870  C  C   . PHE A 1 150 ? 105.134 109.740 125.553 1.00 71.76  ? 150 PHE A C   1 
ATOM   871  O  O   . PHE A 1 150 ? 105.497 109.914 126.722 1.00 71.76  ? 150 PHE A O   1 
ATOM   872  C  CB  . PHE A 1 150 ? 105.682 111.546 123.906 1.00 71.76  ? 150 PHE A CB  1 
ATOM   873  C  CG  . PHE A 1 150 ? 106.771 112.200 123.114 1.00 71.76  ? 150 PHE A CG  1 
ATOM   874  C  CD1 . PHE A 1 150 ? 108.074 111.741 123.196 1.00 71.76  ? 150 PHE A CD1 1 
ATOM   875  C  CD2 . PHE A 1 150 ? 106.497 113.278 122.294 1.00 71.76  ? 150 PHE A CD2 1 
ATOM   876  C  CE1 . PHE A 1 150 ? 109.082 112.339 122.470 1.00 71.76  ? 150 PHE A CE1 1 
ATOM   877  C  CE2 . PHE A 1 150 ? 107.502 113.884 121.564 1.00 71.76  ? 150 PHE A CE2 1 
ATOM   878  C  CZ  . PHE A 1 150 ? 108.796 113.413 121.653 1.00 71.76  ? 150 PHE A CZ  1 
ATOM   879  N  N   . GLN A 1 151 ? 103.947 109.208 125.253 1.00 71.72  ? 151 GLN A N   1 
ATOM   880  C  CA  . GLN A 1 151 ? 103.058 108.773 126.327 1.00 71.72  ? 151 GLN A CA  1 
ATOM   881  C  C   . GLN A 1 151 ? 103.562 107.504 127.003 1.00 71.72  ? 151 GLN A C   1 
ATOM   882  O  O   . GLN A 1 151 ? 103.086 107.156 128.089 1.00 71.72  ? 151 GLN A O   1 
ATOM   883  C  CB  . GLN A 1 151 ? 101.644 108.558 125.789 1.00 71.72  ? 151 GLN A CB  1 
ATOM   884  C  CG  . GLN A 1 151 ? 100.945 109.832 125.345 1.00 71.72  ? 151 GLN A CG  1 
ATOM   885  C  CD  . GLN A 1 151 ? 100.183 110.503 126.468 1.00 71.72  ? 151 GLN A CD  1 
ATOM   886  O  OE1 . GLN A 1 151 ? 99.783  109.860 127.437 1.00 71.72  ? 151 GLN A OE1 1 
ATOM   887  N  NE2 . GLN A 1 151 ? 99.975  111.806 126.341 1.00 71.72  ? 151 GLN A NE2 1 
ATOM   888  N  N   . SER A 1 152 ? 104.512 106.800 126.382 1.00 72.93  ? 152 SER A N   1 
ATOM   889  C  CA  . SER A 1 152 ? 104.984 105.535 126.938 1.00 72.93  ? 152 SER A CA  1 
ATOM   890  C  C   . SER A 1 152 ? 105.958 105.740 128.092 1.00 72.93  ? 152 SER A C   1 
ATOM   891  O  O   . SER A 1 152 ? 106.207 104.808 128.864 1.00 72.93  ? 152 SER A O   1 
ATOM   892  C  CB  . SER A 1 152 ? 105.643 104.695 125.844 1.00 72.93  ? 152 SER A CB  1 
ATOM   893  O  OG  . SER A 1 152 ? 104.733 104.404 124.800 1.00 72.93  ? 152 SER A OG  1 
ATOM   894  N  N   . PHE A 1 153 ? 106.519 106.944 128.227 1.00 73.38  ? 153 PHE A N   1 
ATOM   895  C  CA  . PHE A 1 153 ? 107.562 107.167 129.223 1.00 73.38  ? 153 PHE A CA  1 
ATOM   896  C  C   . PHE A 1 153 ? 107.011 107.166 130.643 1.00 73.38  ? 153 PHE A C   1 
ATOM   897  O  O   . PHE A 1 153 ? 107.784 107.166 131.606 1.00 73.38  ? 153 PHE A O   1 
ATOM   898  C  CB  . PHE A 1 153 ? 108.290 108.477 128.929 1.00 73.38  ? 153 PHE A CB  1 
ATOM   899  C  CG  . PHE A 1 153 ? 109.227 108.394 127.759 1.00 73.38  ? 153 PHE A CG  1 
ATOM   900  C  CD1 . PHE A 1 153 ? 109.973 107.251 127.534 1.00 73.38  ? 153 PHE A CD1 1 
ATOM   901  C  CD2 . PHE A 1 153 ? 109.357 109.453 126.880 1.00 73.38  ? 153 PHE A CD2 1 
ATOM   902  C  CE1 . PHE A 1 153 ? 110.834 107.169 126.461 1.00 73.38  ? 153 PHE A CE1 1 
ATOM   903  C  CE2 . PHE A 1 153 ? 110.215 109.375 125.802 1.00 73.38  ? 153 PHE A CE2 1 
ATOM   904  C  CZ  . PHE A 1 153 ? 110.954 108.229 125.593 1.00 73.38  ? 153 PHE A CZ  1 
ATOM   905  N  N   . GLN A 1 154 ? 105.690 107.170 130.799 1.00 81.56  ? 154 GLN A N   1 
ATOM   906  C  CA  . GLN A 1 154 ? 105.099 107.110 132.127 1.00 81.56  ? 154 GLN A CA  1 
ATOM   907  C  C   . GLN A 1 154 ? 105.317 105.733 132.741 1.00 81.56  ? 154 GLN A C   1 
ATOM   908  O  O   . GLN A 1 154 ? 105.556 104.751 132.035 1.00 81.56  ? 154 GLN A O   1 
ATOM   909  C  CB  . GLN A 1 154 ? 103.605 107.419 132.056 1.00 81.56  ? 154 GLN A CB  1 
ATOM   910  C  CG  . GLN A 1 154 ? 103.279 108.713 131.340 1.00 81.56  ? 154 GLN A CG  1 
ATOM   911  C  CD  . GLN A 1 154 ? 101.865 108.733 130.807 1.00 81.56  ? 154 GLN A CD  1 
ATOM   912  O  OE1 . GLN A 1 154 ? 100.974 108.090 131.361 1.00 81.56  ? 154 GLN A OE1 1 
ATOM   913  N  NE2 . GLN A 1 154 ? 101.651 109.462 129.720 1.00 81.56  ? 154 GLN A NE2 1 
ATOM   914  N  N   . LYS A 1 155 ? 105.240 105.667 134.071 1.00 92.35  ? 155 LYS A N   1 
ATOM   915  C  CA  . LYS A 1 155 ? 105.450 104.399 134.762 1.00 92.35  ? 155 LYS A CA  1 
ATOM   916  C  C   . LYS A 1 155 ? 104.349 103.398 134.429 1.00 92.35  ? 155 LYS A C   1 
ATOM   917  O  O   . LYS A 1 155 ? 104.596 102.189 134.353 1.00 92.35  ? 155 LYS A O   1 
ATOM   918  C  CB  . LYS A 1 155 ? 105.543 104.635 136.271 1.00 92.35  ? 155 LYS A CB  1 
ATOM   919  C  CG  . LYS A 1 155 ? 104.305 105.250 136.897 1.00 92.35  ? 155 LYS A CG  1 
ATOM   920  C  CD  . LYS A 1 155 ? 104.528 105.545 138.370 1.00 92.35  ? 155 LYS A CD  1 
ATOM   921  C  CE  . LYS A 1 155 ? 104.626 104.266 139.185 1.00 92.35  ? 155 LYS A CE  1 
ATOM   922  N  NZ  . LYS A 1 155 ? 103.337 103.524 139.218 1.00 92.35  ? 155 LYS A NZ  1 
ATOM   923  N  N   . GLU A 1 156 ? 103.126 103.880 134.234 1.00 87.44  ? 156 GLU A N   1 
ATOM   924  C  CA  . GLU A 1 156 ? 101.991 103.034 133.891 1.00 87.44  ? 156 GLU A CA  1 
ATOM   925  C  C   . GLU A 1 156 ? 101.456 103.428 132.522 1.00 87.44  ? 156 GLU A C   1 
ATOM   926  O  O   . GLU A 1 156 ? 101.272 104.617 132.241 1.00 87.44  ? 156 GLU A O   1 
ATOM   927  C  CB  . GLU A 1 156 ? 100.889 103.147 134.944 1.00 87.44  ? 156 GLU A CB  1 
ATOM   928  C  CG  . GLU A 1 156 ? 99.571  102.521 134.533 1.00 87.44  ? 156 GLU A CG  1 
ATOM   929  C  CD  . GLU A 1 156 ? 98.554  102.519 135.654 1.00 87.44  ? 156 GLU A CD  1 
ATOM   930  O  OE1 . GLU A 1 156 ? 98.970  102.516 136.831 1.00 87.44  ? 156 GLU A OE1 1 
ATOM   931  O  OE2 . GLU A 1 156 ? 97.341  102.524 135.360 1.00 87.44  ? 156 GLU A OE2 1 
ATOM   932  N  N   . LEU A 1 157 ? 101.212 102.435 131.677 1.00 78.94  ? 157 LEU A N   1 
ATOM   933  C  CA  . LEU A 1 157 ? 100.701 102.702 130.338 1.00 78.94  ? 157 LEU A CA  1 
ATOM   934  C  C   . LEU A 1 157 ? 99.283  103.256 130.422 1.00 78.94  ? 157 LEU A C   1 
ATOM   935  O  O   . LEU A 1 157 ? 98.434  102.671 131.106 1.00 78.94  ? 157 LEU A O   1 
ATOM   936  C  CB  . LEU A 1 157 ? 100.732 101.431 129.496 1.00 78.94  ? 157 LEU A CB  1 
ATOM   937  C  CG  . LEU A 1 157 ? 102.120 100.979 129.039 1.00 78.94  ? 157 LEU A CG  1 
ATOM   938  C  CD1 . LEU A 1 157 ? 102.026 99.787  128.103 1.00 78.94  ? 157 LEU A CD1 1 
ATOM   939  C  CD2 . LEU A 1 157 ? 102.857 102.126 128.375 1.00 78.94  ? 157 LEU A CD2 1 
ATOM   940  N  N   . PRO A 1 158 ? 98.990  104.379 129.760 1.00 77.32  ? 158 PRO A N   1 
ATOM   941  C  CA  . PRO A 1 158 ? 97.659  104.992 129.907 1.00 77.32  ? 158 PRO A CA  1 
ATOM   942  C  C   . PRO A 1 158 ? 96.512  104.123 129.417 1.00 77.32  ? 158 PRO A C   1 
ATOM   943  O  O   . PRO A 1 158 ? 95.418  104.183 129.993 1.00 77.32  ? 158 PRO A O   1 
ATOM   944  C  CB  . PRO A 1 158 ? 97.781  106.282 129.084 1.00 77.32  ? 158 PRO A CB  1 
ATOM   945  C  CG  . PRO A 1 158 ? 98.878  106.017 128.118 1.00 77.32  ? 158 PRO A CG  1 
ATOM   946  C  CD  . PRO A 1 158 ? 99.848  105.128 128.828 1.00 77.32  ? 158 PRO A CD  1 
ATOM   947  N  N   . TRP A 1 159 ? 96.722  103.317 128.379 1.00 73.71  ? 159 TRP A N   1 
ATOM   948  C  CA  . TRP A 1 159 ? 95.652  102.540 127.767 1.00 73.71  ? 159 TRP A CA  1 
ATOM   949  C  C   . TRP A 1 159 ? 95.421  101.197 128.443 1.00 73.71  ? 159 TRP A C   1 
ATOM   950  O  O   . TRP A 1 159 ? 94.549  100.443 128.003 1.00 73.71  ? 159 TRP A O   1 
ATOM   951  C  CB  . TRP A 1 159 ? 95.946  102.318 126.282 1.00 73.71  ? 159 TRP A CB  1 
ATOM   952  C  CG  . TRP A 1 159 ? 97.258  101.651 126.022 1.00 73.71  ? 159 TRP A CG  1 
ATOM   953  C  CD1 . TRP A 1 159 ? 97.541  100.323 126.145 1.00 73.71  ? 159 TRP A CD1 1 
ATOM   954  C  CD2 . TRP A 1 159 ? 98.469  102.280 125.588 1.00 73.71  ? 159 TRP A CD2 1 
ATOM   955  N  NE1 . TRP A 1 159 ? 98.852  100.086 125.818 1.00 73.71  ? 159 TRP A NE1 1 
ATOM   956  C  CE2 . TRP A 1 159 ? 99.444  101.272 125.471 1.00 73.71  ? 159 TRP A CE2 1 
ATOM   957  C  CE3 . TRP A 1 159 ? 98.824  103.599 125.288 1.00 73.71  ? 159 TRP A CE3 1 
ATOM   958  C  CZ2 . TRP A 1 159 ? 100.749 101.540 125.067 1.00 73.71  ? 159 TRP A CZ2 1 
ATOM   959  C  CZ3 . TRP A 1 159 ? 100.119 103.862 124.888 1.00 73.71  ? 159 TRP A CZ3 1 
ATOM   960  C  CH2 . TRP A 1 159 ? 101.065 102.839 124.782 1.00 73.71  ? 159 TRP A CH2 1 
ATOM   961  N  N   . ALA A 1 160 ? 96.184  100.872 129.486 1.00 84.05  ? 160 ALA A N   1 
ATOM   962  C  CA  . ALA A 1 160 ? 95.989  99.600  130.173 1.00 84.05  ? 160 ALA A CA  1 
ATOM   963  C  C   . ALA A 1 160 ? 94.626  99.533  130.851 1.00 84.05  ? 160 ALA A C   1 
ATOM   964  O  O   . ALA A 1 160 ? 93.949  98.501  130.793 1.00 84.05  ? 160 ALA A O   1 
ATOM   965  C  CB  . ALA A 1 160 ? 97.108  99.378  131.190 1.00 84.05  ? 160 ALA A CB  1 
ATOM   966  N  N   . HIS A 1 161 ? 94.207  100.617 131.495 1.00 90.46  ? 161 HIS A N   1 
ATOM   967  C  CA  . HIS A 1 161 ? 92.950  100.684 132.229 1.00 90.46  ? 161 HIS A CA  1 
ATOM   968  C  C   . HIS A 1 161 ? 92.121  101.854 131.707 1.00 90.46  ? 161 HIS A C   1 
ATOM   969  O  O   . HIS A 1 161 ? 92.510  102.543 130.761 1.00 90.46  ? 161 HIS A O   1 
ATOM   970  C  CB  . HIS A 1 161 ? 93.211  100.824 133.731 1.00 90.46  ? 161 HIS A CB  1 
ATOM   971  C  CG  . HIS A 1 161 ? 93.873  99.631  134.345 1.00 90.46  ? 161 HIS A CG  1 
ATOM   972  N  ND1 . HIS A 1 161 ? 95.242  99.485  134.399 1.00 90.46  ? 161 HIS A ND1 1 
ATOM   973  C  CD2 . HIS A 1 161 ? 93.355  98.530  134.940 1.00 90.46  ? 161 HIS A CD2 1 
ATOM   974  C  CE1 . HIS A 1 161 ? 95.539  98.345  134.995 1.00 90.46  ? 161 HIS A CE1 1 
ATOM   975  N  NE2 . HIS A 1 161 ? 94.412  97.746  135.334 1.00 90.46  ? 161 HIS A NE2 1 
ATOM   976  N  N   . CYS A 1 162 ? 90.962  102.081 132.328 1.00 97.43  ? 162 CYS A N   1 
ATOM   977  C  CA  . CYS A 1 162 ? 90.159  103.268 132.026 1.00 97.43  ? 162 CYS A CA  1 
ATOM   978  C  C   . CYS A 1 162 ? 89.681  103.891 133.338 1.00 97.43  ? 162 CYS A C   1 
ATOM   979  O  O   . CYS A 1 162 ? 88.621  103.541 133.863 1.00 97.43  ? 162 CYS A O   1 
ATOM   980  C  CB  . CYS A 1 162 ? 89.002  102.956 131.075 1.00 97.43  ? 162 CYS A CB  1 
ATOM   981  S  SG  . CYS A 1 162 ? 87.644  101.878 131.606 1.00 97.43  ? 162 CYS A SG  1 
ATOM   982  N  N   . ASN A 1 163 ? 90.493  104.809 133.865 1.00 105.23 ? 163 ASN A N   1 
ATOM   983  C  CA  . ASN A 1 163 ? 90.158  105.662 135.008 1.00 105.23 ? 163 ASN A CA  1 
ATOM   984  C  C   . ASN A 1 163 ? 90.769  107.025 134.685 1.00 105.23 ? 163 ASN A C   1 
ATOM   985  O  O   . ASN A 1 163 ? 91.844  107.367 135.180 1.00 105.23 ? 163 ASN A O   1 
ATOM   986  C  CB  . ASN A 1 163 ? 90.735  105.066 136.284 1.00 105.23 ? 163 ASN A CB  1 
ATOM   987  C  CG  . ASN A 1 163 ? 90.241  105.737 137.557 1.00 105.23 ? 163 ASN A CG  1 
ATOM   988  O  OD1 . ASN A 1 163 ? 91.038  106.003 138.457 1.00 105.23 ? 163 ASN A OD1 1 
ATOM   989  N  ND2 . ASN A 1 163 ? 88.947  105.997 137.659 1.00 105.23 ? 163 ASN A ND2 1 
ATOM   990  N  N   . HIS A 1 164 ? 90.042  107.820 133.904 1.00 95.65  ? 164 HIS A N   1 
ATOM   991  C  CA  . HIS A 1 164 ? 90.639  108.951 133.206 1.00 95.65  ? 164 HIS A CA  1 
ATOM   992  C  C   . HIS A 1 164 ? 89.618  110.075 133.105 1.00 95.65  ? 164 HIS A C   1 
ATOM   993  O  O   . HIS A 1 164 ? 88.501  109.979 133.619 1.00 95.65  ? 164 HIS A O   1 
ATOM   994  C  CB  . HIS A 1 164 ? 91.120  108.568 131.796 1.00 95.65  ? 164 HIS A CB  1 
ATOM   995  C  CG  . HIS A 1 164 ? 92.408  107.800 131.755 1.00 95.65  ? 164 HIS A CG  1 
ATOM   996  N  ND1 . HIS A 1 164 ? 93.269  107.869 130.683 1.00 95.65  ? 164 HIS A ND1 1 
ATOM   997  C  CD2 . HIS A 1 164 ? 92.967  106.927 132.624 1.00 95.65  ? 164 HIS A CD2 1 
ATOM   998  C  CE1 . HIS A 1 164 ? 94.312  107.089 130.903 1.00 95.65  ? 164 HIS A CE1 1 
ATOM   999  N  NE2 . HIS A 1 164 ? 94.153  106.505 132.075 1.00 95.65  ? 164 HIS A NE2 1 
ATOM   1000 N  N   . SER A 1 165 ? 90.013  111.145 132.415 1.00 94.08  ? 165 SER A N   1 
ATOM   1001 C  CA  . SER A 1 165 ? 89.133  112.278 132.165 1.00 94.08  ? 165 SER A CA  1 
ATOM   1002 C  C   . SER A 1 165 ? 88.389  112.175 130.841 1.00 94.08  ? 165 SER A C   1 
ATOM   1003 O  O   . SER A 1 165 ? 87.526  113.016 130.571 1.00 94.08  ? 165 SER A O   1 
ATOM   1004 C  CB  . SER A 1 165 ? 89.935  113.580 132.193 1.00 94.08  ? 165 SER A CB  1 
ATOM   1005 O  OG  . SER A 1 165 ? 90.490  113.859 130.919 1.00 94.08  ? 165 SER A OG  1 
ATOM   1006 N  N   . TRP A 1 166 ? 88.699  111.179 130.010 1.00 86.34  ? 166 TRP A N   1 
ATOM   1007 C  CA  . TRP A 1 166 ? 88.033  111.008 128.724 1.00 86.34  ? 166 TRP A CA  1 
ATOM   1008 C  C   . TRP A 1 166 ? 87.411  109.623 128.570 1.00 86.34  ? 166 TRP A C   1 
ATOM   1009 O  O   . TRP A 1 166 ? 87.403  109.069 127.468 1.00 86.34  ? 166 TRP A O   1 
ATOM   1010 C  CB  . TRP A 1 166 ? 89.001  111.306 127.575 1.00 86.34  ? 166 TRP A CB  1 
ATOM   1011 C  CG  . TRP A 1 166 ? 90.178  110.378 127.463 1.00 86.34  ? 166 TRP A CG  1 
ATOM   1012 C  CD1 . TRP A 1 166 ? 90.244  109.215 126.753 1.00 86.34  ? 166 TRP A CD1 1 
ATOM   1013 C  CD2 . TRP A 1 166 ? 91.474  110.561 128.048 1.00 86.34  ? 166 TRP A CD2 1 
ATOM   1014 N  NE1 . TRP A 1 166 ? 91.489  108.651 126.878 1.00 86.34  ? 166 TRP A NE1 1 
ATOM   1015 C  CE2 . TRP A 1 166 ? 92.264  109.459 127.668 1.00 86.34  ? 166 TRP A CE2 1 
ATOM   1016 C  CE3 . TRP A 1 166 ? 92.039  111.544 128.867 1.00 86.34  ? 166 TRP A CE3 1 
ATOM   1017 C  CZ2 . TRP A 1 166 ? 93.590  109.317 128.070 1.00 86.34  ? 166 TRP A CZ2 1 
ATOM   1018 C  CZ3 . TRP A 1 166 ? 93.354  111.397 129.269 1.00 86.34  ? 166 TRP A CZ3 1 
ATOM   1019 C  CH2 . TRP A 1 166 ? 94.114  110.291 128.873 1.00 86.34  ? 166 TRP A CH2 1 
ATOM   1020 N  N   . ASN A 1 167 ? 86.861  109.068 129.645 1.00 91.37  ? 167 ASN A N   1 
ATOM   1021 C  CA  . ASN A 1 167 ? 86.251  107.746 129.626 1.00 91.37  ? 167 ASN A CA  1 
ATOM   1022 C  C   . ASN A 1 167 ? 84.751  107.860 129.863 1.00 91.37  ? 167 ASN A C   1 
ATOM   1023 O  O   . ASN A 1 167 ? 84.309  108.618 130.732 1.00 91.37  ? 167 ASN A O   1 
ATOM   1024 C  CB  . ASN A 1 167 ? 86.878  106.845 130.689 1.00 91.37  ? 167 ASN A CB  1 
ATOM   1025 C  CG  . ASN A 1 167 ? 88.261  106.375 130.309 1.00 91.37  ? 167 ASN A CG  1 
ATOM   1026 O  OD1 . ASN A 1 167 ? 89.098  106.123 131.171 1.00 91.37  ? 167 ASN A OD1 1 
ATOM   1027 N  ND2 . ASN A 1 167 ? 88.510  106.250 129.013 1.00 91.37  ? 167 ASN A ND2 1 
ATOM   1028 N  N   . THR A 1 168 ? 83.976  107.108 129.086 1.00 96.90  ? 168 THR A N   1 
ATOM   1029 C  CA  . THR A 1 168 ? 82.539  107.048 129.277 1.00 96.90  ? 168 THR A CA  1 
ATOM   1030 C  C   . THR A 1 168 ? 82.205  106.242 130.528 1.00 96.90  ? 168 THR A C   1 
ATOM   1031 O  O   . THR A 1 168 ? 83.035  105.481 131.030 1.00 96.90  ? 168 THR A O   1 
ATOM   1032 C  CB  . THR A 1 168 ? 81.863  106.403 128.070 1.00 96.90  ? 168 THR A CB  1 
ATOM   1033 O  OG1 . THR A 1 168 ? 82.212  105.015 128.012 1.00 96.90  ? 168 THR A OG1 1 
ATOM   1034 C  CG2 . THR A 1 168 ? 82.303  107.070 126.796 1.00 96.90  ? 168 THR A CG2 1 
ATOM   1035 N  N   . PRO A 1 169 ? 80.988  106.399 131.059 1.00 102.16 ? 169 PRO A N   1 
ATOM   1036 C  CA  . PRO A 1 169 ? 80.514  105.456 132.083 1.00 102.16 ? 169 PRO A CA  1 
ATOM   1037 C  C   . PRO A 1 169 ? 80.305  104.049 131.550 1.00 102.16 ? 169 PRO A C   1 
ATOM   1038 O  O   . PRO A 1 169 ? 80.113  103.125 132.351 1.00 102.16 ? 169 PRO A O   1 
ATOM   1039 C  CB  . PRO A 1 169 ? 79.189  106.077 132.549 1.00 102.16 ? 169 PRO A CB  1 
ATOM   1040 C  CG  . PRO A 1 169 ? 78.773  106.974 131.435 1.00 102.16 ? 169 PRO A CG  1 
ATOM   1041 C  CD  . PRO A 1 169 ? 80.040  107.504 130.846 1.00 102.16 ? 169 PRO A CD  1 
ATOM   1042 N  N   . HIS A 1 170 ? 80.336  103.860 130.231 1.00 107.88 ? 170 HIS A N   1 
ATOM   1043 C  CA  . HIS A 1 170 ? 80.153  102.555 129.613 1.00 107.88 ? 170 HIS A CA  1 
ATOM   1044 C  C   . HIS A 1 170 ? 81.420  101.710 129.595 1.00 107.88 ? 170 HIS A C   1 
ATOM   1045 O  O   . HIS A 1 170 ? 81.343  100.525 129.255 1.00 107.88 ? 170 HIS A O   1 
ATOM   1046 C  CB  . HIS A 1 170 ? 79.648  102.718 128.176 1.00 107.88 ? 170 HIS A CB  1 
ATOM   1047 C  CG  . HIS A 1 170 ? 78.217  103.147 128.081 1.00 107.88 ? 170 HIS A CG  1 
ATOM   1048 N  ND1 . HIS A 1 170 ? 77.242  102.679 128.935 1.00 107.88 ? 170 HIS A ND1 1 
ATOM   1049 C  CD2 . HIS A 1 170 ? 77.596  103.998 127.230 1.00 107.88 ? 170 HIS A CD2 1 
ATOM   1050 C  CE1 . HIS A 1 170 ? 76.082  103.226 128.617 1.00 107.88 ? 170 HIS A CE1 1 
ATOM   1051 N  NE2 . HIS A 1 170 ? 76.269  104.030 127.586 1.00 107.88 ? 170 HIS A NE2 1 
ATOM   1052 N  N   . CYS A 1 171 ? 82.574  102.277 129.942 1.00 104.87 ? 171 CYS A N   1 
ATOM   1053 C  CA  . CYS A 1 171 ? 83.821  101.532 129.852 1.00 104.87 ? 171 CYS A CA  1 
ATOM   1054 C  C   . CYS A 1 171 ? 83.862  100.410 130.879 1.00 104.87 ? 171 CYS A C   1 
ATOM   1055 O  O   . CYS A 1 171 ? 83.386  100.557 132.008 1.00 104.87 ? 171 CYS A O   1 
ATOM   1056 C  CB  . CYS A 1 171 ? 85.027  102.447 130.060 1.00 104.87 ? 171 CYS A CB  1 
ATOM   1057 S  SG  . CYS A 1 171 ? 86.614  101.573 129.876 1.00 104.87 ? 171 CYS A SG  1 
ATOM   1058 N  N   . MET A 1 172 ? 84.439  99.283  130.476 1.00 106.50 ? 172 MET A N   1 
ATOM   1059 C  CA  . MET A 1 172 ? 84.697  98.172  131.376 1.00 106.50 ? 172 MET A CA  1 
ATOM   1060 C  C   . MET A 1 172 ? 85.982  97.491  130.932 1.00 106.50 ? 172 MET A C   1 
ATOM   1061 O  O   . MET A 1 172 ? 86.362  97.557  129.760 1.00 106.50 ? 172 MET A O   1 
ATOM   1062 C  CB  . MET A 1 172 ? 83.520  97.184  131.406 1.00 106.50 ? 172 MET A CB  1 
ATOM   1063 C  CG  . MET A 1 172 ? 83.669  96.059  132.418 1.00 106.50 ? 172 MET A CG  1 
ATOM   1064 S  SD  . MET A 1 172 ? 82.270  94.925  132.445 1.00 106.50 ? 172 MET A SD  1 
ATOM   1065 C  CE  . MET A 1 172 ? 81.025  95.951  133.223 1.00 106.50 ? 172 MET A CE  1 
ATOM   1066 N  N   . GLU A 1 173 ? 86.658  96.853  131.885 1.00 109.18 ? 173 GLU A N   1 
ATOM   1067 C  CA  . GLU A 1 173 ? 87.937  96.220  131.602 1.00 109.18 ? 173 GLU A CA  1 
ATOM   1068 C  C   . GLU A 1 173 ? 87.770  95.097  130.585 1.00 109.18 ? 173 GLU A C   1 
ATOM   1069 O  O   . GLU A 1 173 ? 86.761  94.388  130.577 1.00 109.18 ? 173 GLU A O   1 
ATOM   1070 C  CB  . GLU A 1 173 ? 88.550  95.678  132.892 1.00 109.18 ? 173 GLU A CB  1 
ATOM   1071 C  CG  . GLU A 1 173 ? 88.833  96.747  133.932 1.00 109.18 ? 173 GLU A CG  1 
ATOM   1072 C  CD  . GLU A 1 173 ? 89.760  96.264  135.028 1.00 109.18 ? 173 GLU A CD  1 
ATOM   1073 O  OE1 . GLU A 1 173 ? 90.133  95.072  135.011 1.00 109.18 ? 173 GLU A OE1 1 
ATOM   1074 O  OE2 . GLU A 1 173 ? 90.116  97.075  135.907 1.00 109.18 ? 173 GLU A OE2 1 
ATOM   1075 N  N   . ASP A 1 174 ? 88.776  94.942  129.720 1.00 103.40 ? 174 ASP A N   1 
ATOM   1076 C  CA  . ASP A 1 174 ? 88.734  93.888  128.712 1.00 103.40 ? 174 ASP A CA  1 
ATOM   1077 C  C   . ASP A 1 174 ? 88.654  92.515  129.361 1.00 103.40 ? 174 ASP A C   1 
ATOM   1078 O  O   . ASP A 1 174 ? 87.954  91.624  128.867 1.00 103.40 ? 174 ASP A O   1 
ATOM   1079 C  CB  . ASP A 1 174 ? 89.959  93.981  127.805 1.00 103.40 ? 174 ASP A CB  1 
ATOM   1080 C  CG  . ASP A 1 174 ? 89.775  94.979  126.684 1.00 103.40 ? 174 ASP A CG  1 
ATOM   1081 O  OD1 . ASP A 1 174 ? 88.777  95.727  126.720 1.00 103.40 ? 174 ASP A OD1 1 
ATOM   1082 O  OD2 . ASP A 1 174 ? 90.626  95.023  125.772 1.00 103.40 ? 174 ASP A OD2 1 
ATOM   1083 N  N   . THR A 1 175 ? 89.371  92.324  130.470 1.00 109.39 ? 175 THR A N   1 
ATOM   1084 C  CA  . THR A 1 175 ? 89.259  91.078  131.219 1.00 109.39 ? 175 THR A CA  1 
ATOM   1085 C  C   . THR A 1 175 ? 87.852  90.896  131.771 1.00 109.39 ? 175 THR A C   1 
ATOM   1086 O  O   . THR A 1 175 ? 87.315  89.782  131.772 1.00 109.39 ? 175 THR A O   1 
ATOM   1087 C  CB  . THR A 1 175 ? 90.287  91.054  132.350 1.00 109.39 ? 175 THR A CB  1 
ATOM   1088 O  OG1 . THR A 1 175 ? 91.600  91.237  131.807 1.00 109.39 ? 175 THR A OG1 1 
ATOM   1089 C  CG2 . THR A 1 175 ? 90.236  89.728  133.092 1.00 109.39 ? 175 THR A CG2 1 
ATOM   1090 N  N   . MET A 1 176 ? 87.236  91.979  132.242 1.00 117.62 ? 176 MET A N   1 
ATOM   1091 C  CA  . MET A 1 176 ? 85.906  91.917  132.831 1.00 117.62 ? 176 MET A CA  1 
ATOM   1092 C  C   . MET A 1 176 ? 84.784  92.078  131.815 1.00 117.62 ? 176 MET A C   1 
ATOM   1093 O  O   . MET A 1 176 ? 83.614  91.936  132.187 1.00 117.62 ? 176 MET A O   1 
ATOM   1094 C  CB  . MET A 1 176 ? 85.758  92.988  133.917 1.00 117.62 ? 176 MET A CB  1 
ATOM   1095 C  CG  . MET A 1 176 ? 86.657  92.779  135.122 1.00 117.62 ? 176 MET A CG  1 
ATOM   1096 S  SD  . MET A 1 176 ? 86.324  91.224  135.969 1.00 117.62 ? 176 MET A SD  1 
ATOM   1097 C  CE  . MET A 1 176 ? 84.710  91.559  136.667 1.00 117.62 ? 176 MET A CE  1 
ATOM   1098 N  N   . ARG A 1 177 ? 85.100  92.374  130.550 1.00 111.03 ? 177 ARG A N   1 
ATOM   1099 C  CA  . ARG A 1 177 ? 84.039  92.589  129.571 1.00 111.03 ? 177 ARG A CA  1 
ATOM   1100 C  C   . ARG A 1 177 ? 83.272  91.309  129.272 1.00 111.03 ? 177 ARG A C   1 
ATOM   1101 O  O   . ARG A 1 177 ? 82.064  91.360  129.028 1.00 111.03 ? 177 ARG A O   1 
ATOM   1102 C  CB  . ARG A 1 177 ? 84.603  93.174  128.278 1.00 111.03 ? 177 ARG A CB  1 
ATOM   1103 C  CG  . ARG A 1 177 ? 83.519  93.532  127.275 1.00 111.03 ? 177 ARG A CG  1 
ATOM   1104 C  CD  . ARG A 1 177 ? 84.072  94.207  126.040 1.00 111.03 ? 177 ARG A CD  1 
ATOM   1105 N  NE  . ARG A 1 177 ? 83.026  94.453  125.056 1.00 111.03 ? 177 ARG A NE  1 
ATOM   1106 C  CZ  . ARG A 1 177 ? 83.219  95.052  123.890 1.00 111.03 ? 177 ARG A CZ  1 
ATOM   1107 N  NH1 . ARG A 1 177 ? 84.412  95.494  123.530 1.00 111.03 ? 177 ARG A NH1 1 
ATOM   1108 N  NH2 . ARG A 1 177 ? 82.190  95.212  123.064 1.00 111.03 ? 177 ARG A NH2 1 
ATOM   1109 N  N   . LYS A 1 178 ? 83.939  90.162  129.285 1.00 119.11 ? 178 LYS A N   1 
ATOM   1110 C  CA  . LYS A 1 178 ? 83.286  88.880  129.038 1.00 119.11 ? 178 LYS A CA  1 
ATOM   1111 C  C   . LYS A 1 178 ? 83.030  88.234  130.394 1.00 119.11 ? 178 LYS A C   1 
ATOM   1112 O  O   . LYS A 1 178 ? 83.918  87.599  130.971 1.00 119.11 ? 178 LYS A O   1 
ATOM   1113 C  CB  . LYS A 1 178 ? 84.134  87.992  128.133 1.00 119.11 ? 178 LYS A CB  1 
ATOM   1114 C  CG  . LYS A 1 178 ? 83.624  86.566  127.988 1.00 119.11 ? 178 LYS A CG  1 
ATOM   1115 C  CD  . LYS A 1 178 ? 84.730  85.633  127.522 1.00 119.11 ? 178 LYS A CD  1 
ATOM   1116 C  CE  . LYS A 1 178 ? 84.419  84.187  127.868 1.00 119.11 ? 178 LYS A CE  1 
ATOM   1117 N  NZ  . LYS A 1 178 ? 85.616  83.314  127.714 1.00 119.11 ? 178 LYS A NZ  1 
ATOM   1118 N  N   . ASN A 1 179 ? 81.815  88.410  130.903 1.00 136.11 ? 179 ASN A N   1 
ATOM   1119 C  CA  . ASN A 1 179 ? 81.428  87.860  132.193 1.00 136.11 ? 179 ASN A CA  1 
ATOM   1120 C  C   . ASN A 1 179 ? 79.935  87.577  132.160 1.00 136.11 ? 179 ASN A C   1 
ATOM   1121 O  O   . ASN A 1 179 ? 79.147  88.445  131.774 1.00 136.11 ? 179 ASN A O   1 
ATOM   1122 C  CB  . ASN A 1 179 ? 81.774  88.826  133.330 1.00 136.11 ? 179 ASN A CB  1 
ATOM   1123 C  CG  . ASN A 1 179 ? 81.640  88.191  134.699 1.00 136.11 ? 179 ASN A CG  1 
ATOM   1124 O  OD1 . ASN A 1 179 ? 81.363  86.999  134.821 1.00 136.11 ? 179 ASN A OD1 1 
ATOM   1125 N  ND2 . ASN A 1 179 ? 81.842  88.989  135.740 1.00 136.11 ? 179 ASN A ND2 1 
ATOM   1126 N  N   . LYS A 1 180 ? 79.556  86.364  132.562 1.00 141.68 ? 180 LYS A N   1 
ATOM   1127 C  CA  . LYS A 1 180 ? 78.160  85.947  132.515 1.00 141.68 ? 180 LYS A CA  1 
ATOM   1128 C  C   . LYS A 1 180 ? 77.298  86.630  133.568 1.00 141.68 ? 180 LYS A C   1 
ATOM   1129 O  O   . LYS A 1 180 ? 76.071  86.490  133.522 1.00 141.68 ? 180 LYS A O   1 
ATOM   1130 C  CB  . LYS A 1 180 ? 78.062  84.429  132.675 1.00 141.68 ? 180 LYS A CB  1 
ATOM   1131 C  CG  . LYS A 1 180 ? 77.979  83.668  131.361 1.00 141.68 ? 180 LYS A CG  1 
ATOM   1132 C  CD  . LYS A 1 180 ? 79.316  83.660  130.639 1.00 141.68 ? 180 LYS A CD  1 
ATOM   1133 C  CE  . LYS A 1 180 ? 80.364  82.885  131.420 1.00 141.68 ? 180 LYS A CE  1 
ATOM   1134 N  NZ  . LYS A 1 180 ? 81.662  82.824  130.693 1.00 141.68 ? 180 LYS A NZ  1 
ATOM   1135 N  N   . SER A 1 181 ? 77.899  87.357  134.507 1.00 142.70 ? 181 SER A N   1 
ATOM   1136 C  CA  . SER A 1 181 ? 77.166  87.954  135.616 1.00 142.70 ? 181 SER A CA  1 
ATOM   1137 C  C   . SER A 1 181 ? 76.787  89.409  135.382 1.00 142.70 ? 181 SER A C   1 
ATOM   1138 O  O   . SER A 1 181 ? 75.686  89.822  135.760 1.00 142.70 ? 181 SER A O   1 
ATOM   1139 C  CB  . SER A 1 181 ? 77.988  87.848  136.905 1.00 142.70 ? 181 SER A CB  1 
ATOM   1140 O  OG  . SER A 1 181 ? 77.379  88.575  137.958 1.00 142.70 ? 181 SER A OG  1 
ATOM   1141 N  N   . VAL A 1 182 ? 77.662  90.201  134.767 1.00 140.39 ? 182 VAL A N   1 
ATOM   1142 C  CA  . VAL A 1 182 ? 77.456  91.641  134.693 1.00 140.39 ? 182 VAL A CA  1 
ATOM   1143 C  C   . VAL A 1 182 ? 77.312  92.163  133.268 1.00 140.39 ? 182 VAL A C   1 
ATOM   1144 O  O   . VAL A 1 182 ? 76.697  93.226  133.076 1.00 140.39 ? 182 VAL A O   1 
ATOM   1145 C  CB  . VAL A 1 182 ? 78.590  92.393  135.426 1.00 140.39 ? 182 VAL A CB  1 
ATOM   1146 C  CG1 . VAL A 1 182 ? 79.876  92.363  134.611 1.00 140.39 ? 182 VAL A CG1 1 
ATOM   1147 C  CG2 . VAL A 1 182 ? 78.174  93.822  135.755 1.00 140.39 ? 182 VAL A CG2 1 
ATOM   1148 N  N   . TRP A 1 183 ? 77.824  91.468  132.252 1.00 134.62 ? 183 TRP A N   1 
ATOM   1149 C  CA  . TRP A 1 183 ? 77.827  91.994  130.891 1.00 134.62 ? 183 TRP A CA  1 
ATOM   1150 C  C   . TRP A 1 183 ? 76.764  91.365  129.999 1.00 134.62 ? 183 TRP A C   1 
ATOM   1151 O  O   . TRP A 1 183 ? 76.039  92.082  129.303 1.00 134.62 ? 183 TRP A O   1 
ATOM   1152 C  CB  . TRP A 1 183 ? 79.206  91.800  130.255 1.00 134.62 ? 183 TRP A CB  1 
ATOM   1153 C  CG  . TRP A 1 183 ? 79.164  91.724  128.758 1.00 134.62 ? 183 TRP A CG  1 
ATOM   1154 C  CD1 . TRP A 1 183 ? 78.972  92.758  127.890 1.00 134.62 ? 183 TRP A CD1 1 
ATOM   1155 C  CD2 . TRP A 1 183 ? 79.324  90.549  127.952 1.00 134.62 ? 183 TRP A CD2 1 
ATOM   1156 N  NE1 . TRP A 1 183 ? 79.001  92.301  126.595 1.00 134.62 ? 183 TRP A NE1 1 
ATOM   1157 C  CE2 . TRP A 1 183 ? 79.216  90.949  126.606 1.00 134.62 ? 183 TRP A CE2 1 
ATOM   1158 C  CE3 . TRP A 1 183 ? 79.548  89.199  128.239 1.00 134.62 ? 183 TRP A CE3 1 
ATOM   1159 C  CZ2 . TRP A 1 183 ? 79.323  90.047  125.549 1.00 134.62 ? 183 TRP A CZ2 1 
ATOM   1160 C  CZ3 . TRP A 1 183 ? 79.654  88.305  127.187 1.00 134.62 ? 183 TRP A CZ3 1 
ATOM   1161 C  CH2 . TRP A 1 183 ? 79.541  88.733  125.860 1.00 134.62 ? 183 TRP A CH2 1 
ATOM   1162 N  N   . ILE A 1 184 ? 76.664  90.034  129.993 1.00 138.39 ? 184 ILE A N   1 
ATOM   1163 C  CA  . ILE A 1 184 ? 75.760  89.354  129.073 1.00 138.39 ? 184 ILE A CA  1 
ATOM   1164 C  C   . ILE A 1 184 ? 74.299  89.651  129.388 1.00 138.39 ? 184 ILE A C   1 
ATOM   1165 O  O   . ILE A 1 184 ? 73.429  89.437  128.537 1.00 138.39 ? 184 ILE A O   1 
ATOM   1166 C  CB  . ILE A 1 184 ? 76.035  87.835  129.090 1.00 138.39 ? 184 ILE A CB  1 
ATOM   1167 C  CG1 . ILE A 1 184 ? 75.529  87.179  127.803 1.00 138.39 ? 184 ILE A CG1 1 
ATOM   1168 C  CG2 . ILE A 1 184 ? 75.399  87.185  130.311 1.00 138.39 ? 184 ILE A CG2 1 
ATOM   1169 C  CD1 . ILE A 1 184 ? 76.108  87.777  126.541 1.00 138.39 ? 184 ILE A CD1 1 
ATOM   1170 N  N   . THR A 1 185 ? 74.006  90.146  130.593 1.00 141.80 ? 185 THR A N   1 
ATOM   1171 C  CA  . THR A 1 185 ? 72.620  90.403  130.970 1.00 141.80 ? 185 THR A CA  1 
ATOM   1172 C  C   . THR A 1 185 ? 72.012  91.540  130.153 1.00 141.80 ? 185 THR A C   1 
ATOM   1173 O  O   . THR A 1 185 ? 70.857  91.447  129.719 1.00 141.80 ? 185 THR A O   1 
ATOM   1174 C  CB  . THR A 1 185 ? 72.525  90.695  132.471 1.00 141.80 ? 185 THR A CB  1 
ATOM   1175 O  OG1 . THR A 1 185 ? 71.185  91.079  132.806 1.00 141.80 ? 185 THR A OG1 1 
ATOM   1176 C  CG2 . THR A 1 185 ? 73.496  91.798  132.884 1.00 141.80 ? 185 THR A CG2 1 
ATOM   1177 N  N   . ILE A 1 186 ? 72.767  92.614  129.921 1.00 139.88 ? 186 ILE A N   1 
ATOM   1178 C  CA  . ILE A 1 186 ? 72.244  93.792  129.236 1.00 139.88 ? 186 ILE A CA  1 
ATOM   1179 C  C   . ILE A 1 186 ? 73.417  94.630  128.750 1.00 139.88 ? 186 ILE A C   1 
ATOM   1180 O  O   . ILE A 1 186 ? 74.539  94.502  129.243 1.00 139.88 ? 186 ILE A O   1 
ATOM   1181 C  CB  . ILE A 1 186 ? 71.307  94.612  130.162 1.00 139.88 ? 186 ILE A CB  1 
ATOM   1182 C  CG1 . ILE A 1 186 ? 70.343  95.465  129.335 1.00 139.88 ? 186 ILE A CG1 1 
ATOM   1183 C  CG2 . ILE A 1 186 ? 72.115  95.480  131.114 1.00 139.88 ? 186 ILE A CG2 1 
ATOM   1184 C  CD1 . ILE A 1 186 ? 69.276  96.153  130.159 1.00 139.88 ? 186 ILE A CD1 1 
ATOM   1185 N  N   . SER A 1 187 ? 73.152  95.492  127.764 1.00 135.44 ? 187 SER A N   1 
ATOM   1186 C  CA  . SER A 1 187 ? 74.129  96.446  127.238 1.00 135.44 ? 187 SER A CA  1 
ATOM   1187 C  C   . SER A 1 187 ? 75.372  95.756  126.686 1.00 135.44 ? 187 SER A C   1 
ATOM   1188 O  O   . SER A 1 187 ? 76.492  96.242  126.858 1.00 135.44 ? 187 SER A O   1 
ATOM   1189 C  CB  . SER A 1 187 ? 74.522  97.481  128.297 1.00 135.44 ? 187 SER A CB  1 
ATOM   1190 O  OG  . SER A 1 187 ? 73.441  98.348  128.591 1.00 135.44 ? 187 SER A OG  1 
ATOM   1191 N  N   . SER A 1 188 ? 75.186  94.616  126.016 1.00 135.73 ? 188 SER A N   1 
ATOM   1192 C  CA  . SER A 1 188 ? 76.321  93.921  125.419 1.00 135.73 ? 188 SER A CA  1 
ATOM   1193 C  C   . SER A 1 188 ? 76.956  94.747  124.307 1.00 135.73 ? 188 SER A C   1 
ATOM   1194 O  O   . SER A 1 188 ? 78.185  94.832  124.210 1.00 135.73 ? 188 SER A O   1 
ATOM   1195 C  CB  . SER A 1 188 ? 75.881  92.556  124.889 1.00 135.73 ? 188 SER A CB  1 
ATOM   1196 O  OG  . SER A 1 188 ? 75.439  91.718  125.943 1.00 135.73 ? 188 SER A OG  1 
ATOM   1197 N  N   . THR A 1 189 ? 76.133  95.362  123.455 1.00 135.47 ? 189 THR A N   1 
ATOM   1198 C  CA  . THR A 1 189 ? 76.647  96.142  122.337 1.00 135.47 ? 189 THR A CA  1 
ATOM   1199 C  C   . THR A 1 189 ? 77.067  97.550  122.737 1.00 135.47 ? 189 THR A C   1 
ATOM   1200 O  O   . THR A 1 189 ? 77.839  98.181  122.007 1.00 135.47 ? 189 THR A O   1 
ATOM   1201 C  CB  . THR A 1 189 ? 75.600  96.223  121.223 1.00 135.47 ? 189 THR A CB  1 
ATOM   1202 O  OG1 . THR A 1 189 ? 74.541  97.100  121.625 1.00 135.47 ? 189 THR A OG1 1 
ATOM   1203 C  CG2 . THR A 1 189 ? 75.025  94.845  120.935 1.00 135.47 ? 189 THR A CG2 1 
ATOM   1204 N  N   . ASN A 1 190 ? 76.579  98.055  123.870 1.00 131.37 ? 190 ASN A N   1 
ATOM   1205 C  CA  . ASN A 1 190 ? 76.908  99.415  124.281 1.00 131.37 ? 190 ASN A CA  1 
ATOM   1206 C  C   . ASN A 1 190 ? 78.328  99.526  124.821 1.00 131.37 ? 190 ASN A C   1 
ATOM   1207 O  O   . ASN A 1 190 ? 78.930  100.602 124.745 1.00 131.37 ? 190 ASN A O   1 
ATOM   1208 C  CB  . ASN A 1 190 ? 75.916  99.900  125.339 1.00 131.37 ? 190 ASN A CB  1 
ATOM   1209 C  CG  . ASN A 1 190 ? 74.477  99.782  124.885 1.00 131.37 ? 190 ASN A CG  1 
ATOM   1210 O  OD1 . ASN A 1 190 ? 73.703  99.009  125.444 1.00 131.37 ? 190 ASN A OD1 1 
ATOM   1211 N  ND2 . ASN A 1 190 ? 74.109  100.547 123.867 1.00 131.37 ? 190 ASN A ND2 1 
ATOM   1212 N  N   . PHE A 1 191 ? 78.873  98.438  125.358 1.00 117.60 ? 191 PHE A N   1 
ATOM   1213 C  CA  . PHE A 1 191 ? 80.165  98.485  126.026 1.00 117.60 ? 191 PHE A CA  1 
ATOM   1214 C  C   . PHE A 1 191 ? 81.288  98.746  125.028 1.00 117.60 ? 191 PHE A C   1 
ATOM   1215 O  O   . PHE A 1 191 ? 81.159  98.512  123.824 1.00 117.60 ? 191 PHE A O   1 
ATOM   1216 C  CB  . PHE A 1 191 ? 80.425  97.178  126.772 1.00 117.60 ? 191 PHE A CB  1 
ATOM   1217 C  CG  . PHE A 1 191 ? 79.682  97.061  128.070 1.00 117.60 ? 191 PHE A CG  1 
ATOM   1218 C  CD1 . PHE A 1 191 ? 80.014  96.076  128.981 1.00 117.60 ? 191 PHE A CD1 1 
ATOM   1219 C  CD2 . PHE A 1 191 ? 78.665  97.943  128.387 1.00 117.60 ? 191 PHE A CD2 1 
ATOM   1220 C  CE1 . PHE A 1 191 ? 79.335  95.963  130.177 1.00 117.60 ? 191 PHE A CE1 1 
ATOM   1221 C  CE2 . PHE A 1 191 ? 77.984  97.837  129.583 1.00 117.60 ? 191 PHE A CE2 1 
ATOM   1222 C  CZ  . PHE A 1 191 ? 78.321  96.845  130.480 1.00 117.60 ? 191 PHE A CZ  1 
ATOM   1223 N  N   . THR A 1 192 ? 82.406  99.242  125.551 1.00 101.09 ? 192 THR A N   1 
ATOM   1224 C  CA  . THR A 1 192 ? 83.579  99.546  124.746 1.00 101.09 ? 192 THR A CA  1 
ATOM   1225 C  C   . THR A 1 192 ? 84.832  99.250  125.559 1.00 101.09 ? 192 THR A C   1 
ATOM   1226 O  O   . THR A 1 192 ? 84.780  99.059  126.777 1.00 101.09 ? 192 THR A O   1 
ATOM   1227 C  CB  . THR A 1 192 ? 83.564  100.999 124.265 1.00 101.09 ? 192 THR A CB  1 
ATOM   1228 O  OG1 . THR A 1 192 ? 84.721  101.251 123.457 1.00 101.09 ? 192 THR A OG1 1 
ATOM   1229 C  CG2 . THR A 1 192 ? 83.546  101.946 125.449 1.00 101.09 ? 192 THR A CG2 1 
ATOM   1230 N  N   . SER A 1 193 ? 85.973  99.212  124.868 1.00 89.61  ? 193 SER A N   1 
ATOM   1231 C  CA  . SER A 1 193 ? 87.236  98.798  125.457 1.00 89.61  ? 193 SER A CA  1 
ATOM   1232 C  C   . SER A 1 193 ? 88.131  100.000 125.749 1.00 89.61  ? 193 SER A C   1 
ATOM   1233 O  O   . SER A 1 193 ? 88.072  101.013 125.046 1.00 89.61  ? 193 SER A O   1 
ATOM   1234 C  CB  . SER A 1 193 ? 87.977  97.832  124.526 1.00 89.61  ? 193 SER A CB  1 
ATOM   1235 O  OG  . SER A 1 193 ? 88.676  98.534  123.515 1.00 89.61  ? 193 SER A OG  1 
ATOM   1236 N  N   . PRO A 1 194 ? 88.966  99.918  126.791 1.00 83.32  ? 194 PRO A N   1 
ATOM   1237 C  CA  . PRO A 1 194 ? 89.855  101.051 127.106 1.00 83.32  ? 194 PRO A CA  1 
ATOM   1238 C  C   . PRO A 1 194 ? 90.799  101.427 125.979 1.00 83.32  ? 194 PRO A C   1 
ATOM   1239 O  O   . PRO A 1 194 ? 91.069  102.617 125.780 1.00 83.32  ? 194 PRO A O   1 
ATOM   1240 C  CB  . PRO A 1 194 ? 90.622  100.563 128.342 1.00 83.32  ? 194 PRO A CB  1 
ATOM   1241 C  CG  . PRO A 1 194 ? 89.787  99.489  128.927 1.00 83.32  ? 194 PRO A CG  1 
ATOM   1242 C  CD  . PRO A 1 194 ? 89.009  98.864  127.817 1.00 83.32  ? 194 PRO A CD  1 
ATOM   1243 N  N   . VAL A 1 195 ? 91.317  100.448 125.236 1.00 74.81  ? 195 VAL A N   1 
ATOM   1244 C  CA  . VAL A 1 195 ? 92.225  100.755 124.136 1.00 74.81  ? 195 VAL A CA  1 
ATOM   1245 C  C   . VAL A 1 195 ? 91.497  101.523 123.041 1.00 74.81  ? 195 VAL A C   1 
ATOM   1246 O  O   . VAL A 1 195 ? 92.007  102.523 122.515 1.00 74.81  ? 195 VAL A O   1 
ATOM   1247 C  CB  . VAL A 1 195 ? 92.858  99.462  123.592 1.00 74.81  ? 195 VAL A CB  1 
ATOM   1248 C  CG1 . VAL A 1 195 ? 93.885  99.785  122.518 1.00 74.81  ? 195 VAL A CG1 1 
ATOM   1249 C  CG2 . VAL A 1 195 ? 93.480  98.657  124.720 1.00 74.81  ? 195 VAL A CG2 1 
ATOM   1250 N  N   . ILE A 1 196 ? 90.292  101.072 122.684 1.00 75.04  ? 196 ILE A N   1 
ATOM   1251 C  CA  . ILE A 1 196 ? 89.520  101.737 121.641 1.00 75.04  ? 196 ILE A CA  1 
ATOM   1252 C  C   . ILE A 1 196 ? 89.119  103.137 122.083 1.00 75.04  ? 196 ILE A C   1 
ATOM   1253 O  O   . ILE A 1 196 ? 89.183  104.090 121.299 1.00 75.04  ? 196 ILE A O   1 
ATOM   1254 C  CB  . ILE A 1 196 ? 88.295  100.885 121.259 1.00 75.04  ? 196 ILE A CB  1 
ATOM   1255 C  CG1 . ILE A 1 196 ? 88.736  99.635  120.498 1.00 75.04  ? 196 ILE A CG1 1 
ATOM   1256 C  CG2 . ILE A 1 196 ? 87.322  101.690 120.417 1.00 75.04  ? 196 ILE A CG2 1 
ATOM   1257 C  CD1 . ILE A 1 196 ? 87.616  98.667  120.218 1.00 75.04  ? 196 ILE A CD1 1 
ATOM   1258 N  N   . GLU A 1 197 ? 88.694  103.285 123.339 1.00 80.13  ? 197 GLU A N   1 
ATOM   1259 C  CA  . GLU A 1 197 ? 88.327  104.604 123.844 1.00 80.13  ? 197 GLU A CA  1 
ATOM   1260 C  C   . GLU A 1 197 ? 89.520  105.549 123.843 1.00 80.13  ? 197 GLU A C   1 
ATOM   1261 O  O   . GLU A 1 197 ? 89.394  106.719 123.464 1.00 80.13  ? 197 GLU A O   1 
ATOM   1262 C  CB  . GLU A 1 197 ? 87.743  104.481 125.248 1.00 80.13  ? 197 GLU A CB  1 
ATOM   1263 C  CG  . GLU A 1 197 ? 86.234  104.454 125.282 1.00 80.13  ? 197 GLU A CG  1 
ATOM   1264 C  CD  . GLU A 1 197 ? 85.694  104.317 126.684 1.00 80.13  ? 197 GLU A CD  1 
ATOM   1265 O  OE1 . GLU A 1 197 ? 86.418  103.781 127.546 1.00 80.13  ? 197 GLU A OE1 1 
ATOM   1266 O  OE2 . GLU A 1 197 ? 84.544  104.735 126.923 1.00 80.13  ? 197 GLU A OE2 1 
ATOM   1267 N  N   . PHE A 1 198 ? 90.687  105.060 124.272 1.00 73.22  ? 198 PHE A N   1 
ATOM   1268 C  CA  . PHE A 1 198 ? 91.899  105.868 124.212 1.00 73.22  ? 198 PHE A CA  1 
ATOM   1269 C  C   . PHE A 1 198 ? 92.160  106.338 122.789 1.00 73.22  ? 198 PHE A C   1 
ATOM   1270 O  O   . PHE A 1 198 ? 92.280  107.542 122.536 1.00 73.22  ? 198 PHE A O   1 
ATOM   1271 C  CB  . PHE A 1 198 ? 93.089  105.065 124.746 1.00 73.22  ? 198 PHE A CB  1 
ATOM   1272 C  CG  . PHE A 1 198 ? 94.354  105.866 124.884 1.00 73.22  ? 198 PHE A CG  1 
ATOM   1273 C  CD1 . PHE A 1 198 ? 94.629  106.557 126.050 1.00 73.22  ? 198 PHE A CD1 1 
ATOM   1274 C  CD2 . PHE A 1 198 ? 95.271  105.925 123.849 1.00 73.22  ? 198 PHE A CD2 1 
ATOM   1275 C  CE1 . PHE A 1 198 ? 95.792  107.293 126.177 1.00 73.22  ? 198 PHE A CE1 1 
ATOM   1276 C  CE2 . PHE A 1 198 ? 96.432  106.660 123.972 1.00 73.22  ? 198 PHE A CE2 1 
ATOM   1277 C  CZ  . PHE A 1 198 ? 96.693  107.343 125.135 1.00 73.22  ? 198 PHE A CZ  1 
ATOM   1278 N  N   . TRP A 1 199 ? 92.174  105.401 121.838 1.00 68.16  ? 199 TRP A N   1 
ATOM   1279 C  CA  . TRP A 1 199 ? 92.463  105.745 120.449 1.00 68.16  ? 199 TRP A CA  1 
ATOM   1280 C  C   . TRP A 1 199 ? 91.443  106.723 119.879 1.00 68.16  ? 199 TRP A C   1 
ATOM   1281 O  O   . TRP A 1 199 ? 91.809  107.623 119.116 1.00 68.16  ? 199 TRP A O   1 
ATOM   1282 C  CB  . TRP A 1 199 ? 92.517  104.468 119.609 1.00 68.16  ? 199 TRP A CB  1 
ATOM   1283 C  CG  . TRP A 1 199 ? 92.391  104.675 118.132 1.00 68.16  ? 199 TRP A CG  1 
ATOM   1284 C  CD1 . TRP A 1 199 ? 91.330  104.335 117.349 1.00 68.16  ? 199 TRP A CD1 1 
ATOM   1285 C  CD2 . TRP A 1 199 ? 93.371  105.242 117.257 1.00 68.16  ? 199 TRP A CD2 1 
ATOM   1286 N  NE1 . TRP A 1 199 ? 91.582  104.666 116.043 1.00 68.16  ? 199 TRP A NE1 1 
ATOM   1287 C  CE2 . TRP A 1 199 ? 92.829  105.224 115.959 1.00 68.16  ? 199 TRP A CE2 1 
ATOM   1288 C  CE3 . TRP A 1 199 ? 94.650  105.768 117.445 1.00 68.16  ? 199 TRP A CE3 1 
ATOM   1289 C  CZ2 . TRP A 1 199 ? 93.522  105.712 114.856 1.00 68.16  ? 199 TRP A CZ2 1 
ATOM   1290 C  CZ3 . TRP A 1 199 ? 95.334  106.251 116.352 1.00 68.16  ? 199 TRP A CZ3 1 
ATOM   1291 C  CH2 . TRP A 1 199 ? 94.770  106.220 115.073 1.00 68.16  ? 199 TRP A CH2 1 
ATOM   1292 N  N   . GLU A 1 200 ? 90.168  106.572 120.238 1.00 74.66  ? 200 GLU A N   1 
ATOM   1293 C  CA  . GLU A 1 200 ? 89.106  107.406 119.685 1.00 74.66  ? 200 GLU A CA  1 
ATOM   1294 C  C   . GLU A 1 200 ? 89.073  108.807 120.284 1.00 74.66  ? 200 GLU A C   1 
ATOM   1295 O  O   . GLU A 1 200 ? 88.762  109.770 119.579 1.00 74.66  ? 200 GLU A O   1 
ATOM   1296 C  CB  . GLU A 1 200 ? 87.745  106.732 119.879 1.00 74.66  ? 200 GLU A CB  1 
ATOM   1297 C  CG  . GLU A 1 200 ? 87.489  105.560 118.953 1.00 74.66  ? 200 GLU A CG  1 
ATOM   1298 C  CD  . GLU A 1 200 ? 86.129  104.936 119.178 1.00 74.66  ? 200 GLU A CD  1 
ATOM   1299 O  OE1 . GLU A 1 200 ? 85.442  105.337 120.141 1.00 74.66  ? 200 GLU A OE1 1 
ATOM   1300 O  OE2 . GLU A 1 200 ? 85.744  104.046 118.392 1.00 74.66  ? 200 GLU A OE2 1 
ATOM   1301 N  N   . ARG A 1 201 ? 89.375  108.949 121.575 1.00 77.77  ? 201 ARG A N   1 
ATOM   1302 C  CA  . ARG A 1 201 ? 89.235  110.262 122.196 1.00 77.77  ? 201 ARG A CA  1 
ATOM   1303 C  C   . ARG A 1 201 ? 90.566  110.952 122.488 1.00 77.77  ? 201 ARG A C   1 
ATOM   1304 O  O   . ARG A 1 201 ? 90.762  112.104 122.089 1.00 77.77  ? 201 ARG A O   1 
ATOM   1305 C  CB  . ARG A 1 201 ? 88.390  110.162 123.467 1.00 77.77  ? 201 ARG A CB  1 
ATOM   1306 C  CG  . ARG A 1 201 ? 86.937  109.868 123.174 1.00 77.77  ? 201 ARG A CG  1 
ATOM   1307 C  CD  . ARG A 1 201 ? 86.099  109.885 124.427 1.00 77.77  ? 201 ARG A CD  1 
ATOM   1308 N  NE  . ARG A 1 201 ? 84.700  109.625 124.121 1.00 77.77  ? 201 ARG A NE  1 
ATOM   1309 C  CZ  . ARG A 1 201 ? 83.728  109.592 125.021 1.00 77.77  ? 201 ARG A CZ  1 
ATOM   1310 N  NH1 . ARG A 1 201 ? 83.969  109.794 126.305 1.00 77.77  ? 201 ARG A NH1 1 
ATOM   1311 N  NH2 . ARG A 1 201 ? 82.480  109.374 124.618 1.00 77.77  ? 201 ARG A NH2 1 
ATOM   1312 N  N   . ASN A 1 202 ? 91.481  110.287 123.196 1.00 71.89  ? 202 ASN A N   1 
ATOM   1313 C  CA  . ASN A 1 202 ? 92.689  110.990 123.615 1.00 71.89  ? 202 ASN A CA  1 
ATOM   1314 C  C   . ASN A 1 202 ? 93.554  111.349 122.417 1.00 71.89  ? 202 ASN A C   1 
ATOM   1315 O  O   . ASN A 1 202 ? 94.107  112.452 122.342 1.00 71.89  ? 202 ASN A O   1 
ATOM   1316 C  CB  . ASN A 1 202 ? 93.481  110.152 124.614 1.00 71.89  ? 202 ASN A CB  1 
ATOM   1317 C  CG  . ASN A 1 202 ? 94.738  110.854 125.082 1.00 71.89  ? 202 ASN A CG  1 
ATOM   1318 O  OD1 . ASN A 1 202 ? 95.815  110.669 124.520 1.00 71.89  ? 202 ASN A OD1 1 
ATOM   1319 N  ND2 . ASN A 1 202 ? 94.602  111.679 126.109 1.00 71.89  ? 202 ASN A ND2 1 
ATOM   1320 N  N   . VAL A 1 203 ? 93.674  110.434 121.461 1.00 66.32  ? 203 VAL A N   1 
ATOM   1321 C  CA  . VAL A 1 203 ? 94.526  110.653 120.301 1.00 66.32  ? 203 VAL A CA  1 
ATOM   1322 C  C   . VAL A 1 203 ? 93.714  111.318 119.198 1.00 66.32  ? 203 VAL A C   1 
ATOM   1323 O  O   . VAL A 1 203 ? 94.165  112.287 118.580 1.00 66.32  ? 203 VAL A O   1 
ATOM   1324 C  CB  . VAL A 1 203 ? 95.149  109.334 119.812 1.00 66.32  ? 203 VAL A CB  1 
ATOM   1325 C  CG1 . VAL A 1 203 ? 96.149  109.599 118.702 1.00 66.32  ? 203 VAL A CG1 1 
ATOM   1326 C  CG2 . VAL A 1 203 ? 95.804  108.601 120.964 1.00 66.32  ? 203 VAL A CG2 1 
ATOM   1327 N  N   . LEU A 1 204 ? 92.510  110.802 118.943 1.00 68.57  ? 204 LEU A N   1 
ATOM   1328 C  CA  . LEU A 1 204 ? 91.722  111.297 117.820 1.00 68.57  ? 204 LEU A CA  1 
ATOM   1329 C  C   . LEU A 1 204 ? 90.732  112.372 118.253 1.00 68.57  ? 204 LEU A C   1 
ATOM   1330 O  O   . LEU A 1 204 ? 90.679  113.450 117.647 1.00 68.57  ? 204 LEU A O   1 
ATOM   1331 C  CB  . LEU A 1 204 ? 90.986  110.138 117.146 1.00 68.57  ? 204 LEU A CB  1 
ATOM   1332 C  CG  . LEU A 1 204 ? 91.790  109.227 116.219 1.00 68.57  ? 204 LEU A CG  1 
ATOM   1333 C  CD1 . LEU A 1 204 ? 90.875  108.211 115.565 1.00 68.57  ? 204 LEU A CD1 1 
ATOM   1334 C  CD2 . LEU A 1 204 ? 92.532  110.035 115.172 1.00 68.57  ? 204 LEU A CD2 1 
ATOM   1335 N  N   . SER A 1 205 ? 89.943  112.099 119.296 1.00 74.88  ? 205 SER A N   1 
ATOM   1336 C  CA  . SER A 1 205 ? 88.820  112.951 119.698 1.00 74.88  ? 205 SER A CA  1 
ATOM   1337 C  C   . SER A 1 205 ? 87.829  113.113 118.546 1.00 74.88  ? 205 SER A C   1 
ATOM   1338 O  O   . SER A 1 205 ? 87.661  114.196 117.981 1.00 74.88  ? 205 SER A O   1 
ATOM   1339 C  CB  . SER A 1 205 ? 89.303  114.308 120.214 1.00 74.88  ? 205 SER A CB  1 
ATOM   1340 O  OG  . SER A 1 205 ? 89.640  115.168 119.143 1.00 74.88  ? 205 SER A OG  1 
ATOM   1341 N  N   . LEU A 1 206 ? 87.184  112.002 118.187 1.00 72.27  ? 206 LEU A N   1 
ATOM   1342 C  CA  . LEU A 1 206 ? 86.304  111.975 117.025 1.00 72.27  ? 206 LEU A CA  1 
ATOM   1343 C  C   . LEU A 1 206 ? 85.133  112.937 117.172 1.00 72.27  ? 206 LEU A C   1 
ATOM   1344 O  O   . LEU A 1 206 ? 84.456  112.973 118.202 1.00 72.27  ? 206 LEU A O   1 
ATOM   1345 C  CB  . LEU A 1 206 ? 85.771  110.562 116.793 1.00 72.27  ? 206 LEU A CB  1 
ATOM   1346 C  CG  . LEU A 1 206 ? 86.667  109.552 116.084 1.00 72.27  ? 206 LEU A CG  1 
ATOM   1347 C  CD1 . LEU A 1 206 ? 86.030  108.180 116.142 1.00 72.27  ? 206 LEU A CD1 1 
ATOM   1348 C  CD2 . LEU A 1 206 ? 86.878  109.976 114.643 1.00 72.27  ? 206 LEU A CD2 1 
ATOM   1349 N  N   . SER A 1 207 ? 84.897  113.708 116.122 1.00 74.39  ? 207 SER A N   1 
ATOM   1350 C  CA  . SER A 1 207 ? 83.717  114.546 115.986 1.00 74.39  ? 207 SER A CA  1 
ATOM   1351 C  C   . SER A 1 207 ? 82.574  113.734 115.395 1.00 74.39  ? 207 SER A C   1 
ATOM   1352 O  O   . SER A 1 207 ? 82.776  112.627 114.891 1.00 74.39  ? 207 SER A O   1 
ATOM   1353 C  CB  . SER A 1 207 ? 84.048  115.755 115.115 1.00 74.39  ? 207 SER A CB  1 
ATOM   1354 O  OG  . SER A 1 207 ? 84.046  115.412 113.742 1.00 74.39  ? 207 SER A OG  1 
ATOM   1355 N  N   . PRO A 1 208 ? 81.339  114.246 115.459 1.00 75.10  ? 208 PRO A N   1 
ATOM   1356 C  CA  . PRO A 1 208 ? 80.212  113.500 114.870 1.00 75.10  ? 208 PRO A CA  1 
ATOM   1357 C  C   . PRO A 1 208 ? 80.373  113.178 113.391 1.00 75.10  ? 208 PRO A C   1 
ATOM   1358 O  O   . PRO A 1 208 ? 79.834  112.165 112.929 1.00 75.10  ? 208 PRO A O   1 
ATOM   1359 C  CB  . PRO A 1 208 ? 79.023  114.434 115.122 1.00 75.10  ? 208 PRO A CB  1 
ATOM   1360 C  CG  . PRO A 1 208 ? 79.385  115.150 116.363 1.00 75.10  ? 208 PRO A CG  1 
ATOM   1361 C  CD  . PRO A 1 208 ? 80.871  115.370 116.290 1.00 75.10  ? 208 PRO A CD  1 
ATOM   1362 N  N   . GLY A 1 209 ? 81.084  114.005 112.630 1.00 72.76  ? 209 GLY A N   1 
ATOM   1363 C  CA  . GLY A 1 209 ? 81.284  113.705 111.227 1.00 72.76  ? 209 GLY A CA  1 
ATOM   1364 C  C   . GLY A 1 209 ? 82.340  114.597 110.617 1.00 72.76  ? 209 GLY A C   1 
ATOM   1365 O  O   . GLY A 1 209 ? 82.946  115.434 111.288 1.00 72.76  ? 209 GLY A O   1 
ATOM   1366 N  N   . ILE A 1 210 ? 82.562  114.397 109.316 1.00 68.65  ? 210 ILE A N   1 
ATOM   1367 C  CA  . ILE A 1 210 ? 83.491  115.244 108.576 1.00 68.65  ? 210 ILE A CA  1 
ATOM   1368 C  C   . ILE A 1 210 ? 82.951  116.663 108.470 1.00 68.65  ? 210 ILE A C   1 
ATOM   1369 O  O   . ILE A 1 210 ? 83.722  117.626 108.379 1.00 68.65  ? 210 ILE A O   1 
ATOM   1370 C  CB  . ILE A 1 210 ? 83.779  114.635 107.188 1.00 68.65  ? 210 ILE A CB  1 
ATOM   1371 C  CG1 . ILE A 1 210 ? 84.812  115.471 106.431 1.00 68.65  ? 210 ILE A CG1 1 
ATOM   1372 C  CG2 . ILE A 1 210 ? 82.502  114.512 106.378 1.00 68.65  ? 210 ILE A CG2 1 
ATOM   1373 C  CD1 . ILE A 1 210 ? 85.453  114.745 105.277 1.00 68.65  ? 210 ILE A CD1 1 
ATOM   1374 N  N   . ASP A 1 211 ? 81.625  116.819 108.485 1.00 77.39  ? 211 ASP A N   1 
ATOM   1375 C  CA  . ASP A 1 211 ? 81.029  118.145 108.365 1.00 77.39  ? 211 ASP A CA  1 
ATOM   1376 C  C   . ASP A 1 211 ? 81.292  119.003 109.597 1.00 77.39  ? 211 ASP A C   1 
ATOM   1377 O  O   . ASP A 1 211 ? 81.110  120.225 109.548 1.00 77.39  ? 211 ASP A O   1 
ATOM   1378 C  CB  . ASP A 1 211 ? 79.529  118.018 108.103 1.00 77.39  ? 211 ASP A CB  1 
ATOM   1379 C  CG  . ASP A 1 211 ? 78.830  117.145 109.125 1.00 77.39  ? 211 ASP A CG  1 
ATOM   1380 O  OD1 . ASP A 1 211 ? 79.518  116.578 109.998 1.00 77.39  ? 211 ASP A OD1 1 
ATOM   1381 O  OD2 . ASP A 1 211 ? 77.590  117.018 109.053 1.00 77.39  ? 211 ASP A OD2 1 
ATOM   1382 N  N   . HIS A 1 212 ? 81.709  118.392 110.708 1.00 78.87  ? 212 HIS A N   1 
ATOM   1383 C  CA  . HIS A 1 212 ? 82.036  119.130 111.919 1.00 78.87  ? 212 HIS A CA  1 
ATOM   1384 C  C   . HIS A 1 212 ? 83.530  119.015 112.192 1.00 78.87  ? 212 HIS A C   1 
ATOM   1385 O  O   . HIS A 1 212 ? 83.951  118.109 112.927 1.00 78.87  ? 212 HIS A O   1 
ATOM   1386 C  CB  . HIS A 1 212 ? 81.231  118.602 113.108 1.00 78.87  ? 212 HIS A CB  1 
ATOM   1387 C  CG  . HIS A 1 212 ? 79.756  118.539 112.861 1.00 78.87  ? 212 HIS A CG  1 
ATOM   1388 N  ND1 . HIS A 1 212 ? 79.130  119.291 111.890 1.00 78.87  ? 212 HIS A ND1 1 
ATOM   1389 C  CD2 . HIS A 1 212 ? 78.781  117.816 113.463 1.00 78.87  ? 212 HIS A CD2 1 
ATOM   1390 C  CE1 . HIS A 1 212 ? 77.834  119.033 111.903 1.00 78.87  ? 212 HIS A CE1 1 
ATOM   1391 N  NE2 . HIS A 1 212 ? 77.597  118.141 112.848 1.00 78.87  ? 212 HIS A NE2 1 
ATOM   1392 N  N   . PRO A 1 213 ? 84.370  119.890 111.631 1.00 75.29  ? 213 PRO A N   1 
ATOM   1393 C  CA  . PRO A 1 213 ? 85.820  119.759 111.860 1.00 75.29  ? 213 PRO A CA  1 
ATOM   1394 C  C   . PRO A 1 213 ? 86.233  119.890 113.316 1.00 75.29  ? 213 PRO A C   1 
ATOM   1395 O  O   . PRO A 1 213 ? 87.155  119.195 113.755 1.00 75.29  ? 213 PRO A O   1 
ATOM   1396 C  CB  . PRO A 1 213 ? 86.410  120.886 110.999 1.00 75.29  ? 213 PRO A CB  1 
ATOM   1397 C  CG  . PRO A 1 213 ? 85.339  121.227 110.016 1.00 75.29  ? 213 PRO A CG  1 
ATOM   1398 C  CD  . PRO A 1 213 ? 84.054  121.016 110.740 1.00 75.29  ? 213 PRO A CD  1 
ATOM   1399 N  N   . GLY A 1 214 ? 85.575  120.753 114.083 1.00 76.25  ? 214 GLY A N   1 
ATOM   1400 C  CA  . GLY A 1 214 ? 85.978  120.971 115.457 1.00 76.25  ? 214 GLY A CA  1 
ATOM   1401 C  C   . GLY A 1 214 ? 87.158  121.922 115.569 1.00 76.25  ? 214 GLY A C   1 
ATOM   1402 O  O   . GLY A 1 214 ? 87.363  122.815 114.741 1.00 76.25  ? 214 GLY A O   1 
ATOM   1403 N  N   . SER A 1 215 ? 87.944  121.718 116.621 1.00 74.91  ? 215 SER A N   1 
ATOM   1404 C  CA  . SER A 1 215 ? 89.109  122.544 116.904 1.00 74.91  ? 215 SER A CA  1 
ATOM   1405 C  C   . SER A 1 215 ? 90.399  121.786 116.605 1.00 74.91  ? 215 SER A C   1 
ATOM   1406 O  O   . SER A 1 215 ? 90.434  120.555 116.550 1.00 74.91  ? 215 SER A O   1 
ATOM   1407 C  CB  . SER A 1 215 ? 89.093  123.009 118.362 1.00 74.91  ? 215 SER A CB  1 
ATOM   1408 O  OG  . SER A 1 215 ? 89.297  121.919 119.243 1.00 74.91  ? 215 SER A OG  1 
ATOM   1409 N  N   . LEU A 1 216 ? 91.472  122.547 116.409 1.00 70.13  ? 216 LEU A N   1 
ATOM   1410 C  CA  . LEU A 1 216 ? 92.784  121.971 116.153 1.00 70.13  ? 216 LEU A CA  1 
ATOM   1411 C  C   . LEU A 1 216 ? 93.384  121.400 117.432 1.00 70.13  ? 216 LEU A C   1 
ATOM   1412 O  O   . LEU A 1 216 ? 93.180  121.926 118.530 1.00 70.13  ? 216 LEU A O   1 
ATOM   1413 C  CB  . LEU A 1 216 ? 93.723  123.024 115.566 1.00 70.13  ? 216 LEU A CB  1 
ATOM   1414 C  CG  . LEU A 1 216 ? 95.005  122.539 114.888 1.00 70.13  ? 216 LEU A CG  1 
ATOM   1415 C  CD1 . LEU A 1 216 ? 94.710  121.994 113.505 1.00 70.13  ? 216 LEU A CD1 1 
ATOM   1416 C  CD2 . LEU A 1 216 ? 96.020  123.664 114.808 1.00 70.13  ? 216 LEU A CD2 1 
ATOM   1417 N  N   . LYS A 1 217 ? 94.131  120.309 117.281 1.00 70.27  ? 217 LYS A N   1 
ATOM   1418 C  CA  . LYS A 1 217 ? 94.852  119.687 118.384 1.00 70.27  ? 217 LYS A CA  1 
ATOM   1419 C  C   . LYS A 1 217 ? 96.317  120.097 118.293 1.00 70.27  ? 217 LYS A C   1 
ATOM   1420 O  O   . LYS A 1 217 ? 96.952  119.911 117.250 1.00 70.27  ? 217 LYS A O   1 
ATOM   1421 C  CB  . LYS A 1 217 ? 94.706  118.166 118.346 1.00 70.27  ? 217 LYS A CB  1 
ATOM   1422 C  CG  . LYS A 1 217 ? 93.313  117.678 118.697 1.00 70.27  ? 217 LYS A CG  1 
ATOM   1423 C  CD  . LYS A 1 217 ? 93.325  116.232 119.159 1.00 70.27  ? 217 LYS A CD  1 
ATOM   1424 C  CE  . LYS A 1 217 ? 94.184  116.049 120.393 1.00 70.27  ? 217 LYS A CE  1 
ATOM   1425 N  NZ  . LYS A 1 217 ? 93.797  114.835 121.160 1.00 70.27  ? 217 LYS A NZ  1 
ATOM   1426 N  N   . TRP A 1 218 ? 96.847  120.656 119.381 1.00 75.57  ? 218 TRP A N   1 
ATOM   1427 C  CA  . TRP A 1 218 ? 98.163  121.283 119.324 1.00 75.57  ? 218 TRP A CA  1 
ATOM   1428 C  C   . TRP A 1 218 ? 99.289  120.289 119.584 1.00 75.57  ? 218 TRP A C   1 
ATOM   1429 O  O   . TRP A 1 218 ? 100.368 120.410 118.995 1.00 75.57  ? 218 TRP A O   1 
ATOM   1430 C  CB  . TRP A 1 218 ? 98.227  122.442 120.317 1.00 75.57  ? 218 TRP A CB  1 
ATOM   1431 C  CG  . TRP A 1 218 ? 97.380  123.602 119.908 1.00 75.57  ? 218 TRP A CG  1 
ATOM   1432 C  CD1 . TRP A 1 218 ? 96.203  123.996 120.471 1.00 75.57  ? 218 TRP A CD1 1 
ATOM   1433 C  CD2 . TRP A 1 218 ? 97.638  124.517 118.837 1.00 75.57  ? 218 TRP A CD2 1 
ATOM   1434 N  NE1 . TRP A 1 218 ? 95.713  125.102 119.820 1.00 75.57  ? 218 TRP A NE1 1 
ATOM   1435 C  CE2 . TRP A 1 218 ? 96.577  125.442 118.813 1.00 75.57  ? 218 TRP A CE2 1 
ATOM   1436 C  CE3 . TRP A 1 218 ? 98.664  124.645 117.896 1.00 75.57  ? 218 TRP A CE3 1 
ATOM   1437 C  CZ2 . TRP A 1 218 ? 96.512  126.479 117.887 1.00 75.57  ? 218 TRP A CZ2 1 
ATOM   1438 C  CZ3 . TRP A 1 218 ? 98.599  125.675 116.979 1.00 75.57  ? 218 TRP A CZ3 1 
ATOM   1439 C  CH2 . TRP A 1 218 ? 97.530  126.579 116.981 1.00 75.57  ? 218 TRP A CH2 1 
ATOM   1440 N  N   . ASP A 1 219 ? 99.068  119.311 120.462 1.00 69.92  ? 219 ASP A N   1 
ATOM   1441 C  CA  . ASP A 1 219 ? 100.109 118.325 120.733 1.00 69.92  ? 219 ASP A CA  1 
ATOM   1442 C  C   . ASP A 1 219 ? 100.405 117.472 119.502 1.00 69.92  ? 219 ASP A C   1 
ATOM   1443 O  O   . ASP A 1 219 ? 101.570 117.168 119.215 1.00 69.92  ? 219 ASP A O   1 
ATOM   1444 C  CB  . ASP A 1 219 ? 99.712  117.462 121.929 1.00 69.92  ? 219 ASP A CB  1 
ATOM   1445 C  CG  . ASP A 1 219 ? 98.272  117.003 121.866 1.00 69.92  ? 219 ASP A CG  1 
ATOM   1446 O  OD1 . ASP A 1 219 ? 97.581  117.345 120.886 1.00 69.92  ? 219 ASP A OD1 1 
ATOM   1447 O  OD2 . ASP A 1 219 ? 97.825  116.312 122.803 1.00 69.92  ? 219 ASP A OD2 1 
ATOM   1448 N  N   . LEU A 1 220 ? 99.368  117.080 118.759 1.00 67.99  ? 220 LEU A N   1 
ATOM   1449 C  CA  . LEU A 1 220 ? 99.591  116.310 117.540 1.00 67.99  ? 220 LEU A CA  1 
ATOM   1450 C  C   . LEU A 1 220 ? 100.301 117.144 116.482 1.00 67.99  ? 220 LEU A C   1 
ATOM   1451 O  O   . LEU A 1 220 ? 101.146 116.627 115.741 1.00 67.99  ? 220 LEU A O   1 
ATOM   1452 C  CB  . LEU A 1 220 ? 98.266  115.774 117.004 1.00 67.99  ? 220 LEU A CB  1 
ATOM   1453 C  CG  . LEU A 1 220 ? 97.691  114.564 117.738 1.00 67.99  ? 220 LEU A CG  1 
ATOM   1454 C  CD1 . LEU A 1 220 ? 96.341  114.195 117.164 1.00 67.99  ? 220 LEU A CD1 1 
ATOM   1455 C  CD2 . LEU A 1 220 ? 98.645  113.388 117.662 1.00 67.99  ? 220 LEU A CD2 1 
ATOM   1456 N  N   . ALA A 1 221 ? 99.973  118.434 116.393 1.00 69.84  ? 221 ALA A N   1 
ATOM   1457 C  CA  . ALA A 1 221 ? 100.696 119.316 115.482 1.00 69.84  ? 221 ALA A CA  1 
ATOM   1458 C  C   . ALA A 1 221 ? 102.162 119.430 115.879 1.00 69.84  ? 221 ALA A C   1 
ATOM   1459 O  O   . ALA A 1 221 ? 103.048 119.469 115.016 1.00 69.84  ? 221 ALA A O   1 
ATOM   1460 C  CB  . ALA A 1 221 ? 100.036 120.693 115.449 1.00 69.84  ? 221 ALA A CB  1 
ATOM   1461 N  N   . LEU A 1 222 ? 102.438 119.483 117.184 1.00 70.09  ? 222 LEU A N   1 
ATOM   1462 C  CA  . LEU A 1 222 ? 103.821 119.527 117.649 1.00 70.09  ? 222 LEU A CA  1 
ATOM   1463 C  C   . LEU A 1 222 ? 104.568 118.250 117.288 1.00 70.09  ? 222 LEU A C   1 
ATOM   1464 O  O   . LEU A 1 222 ? 105.724 118.300 116.854 1.00 70.09  ? 222 LEU A O   1 
ATOM   1465 C  CB  . LEU A 1 222 ? 103.855 119.761 119.158 1.00 70.09  ? 222 LEU A CB  1 
ATOM   1466 C  CG  . LEU A 1 222 ? 105.102 120.456 119.702 1.00 70.09  ? 222 LEU A CG  1 
ATOM   1467 C  CD1 . LEU A 1 222 ? 105.097 121.921 119.309 1.00 70.09  ? 222 LEU A CD1 1 
ATOM   1468 C  CD2 . LEU A 1 222 ? 105.185 120.302 121.209 1.00 70.09  ? 222 LEU A CD2 1 
ATOM   1469 N  N   . CYS A 1 223 ? 103.925 117.093 117.467 1.00 69.28  ? 223 CYS A N   1 
ATOM   1470 C  CA  . CYS A 1 223 ? 104.557 115.829 117.092 1.00 69.28  ? 223 CYS A CA  1 
ATOM   1471 C  C   . CYS A 1 223 ? 104.823 115.766 115.591 1.00 69.28  ? 223 CYS A C   1 
ATOM   1472 O  O   . CYS A 1 223 ? 105.885 115.297 115.156 1.00 69.28  ? 223 CYS A O   1 
ATOM   1473 C  CB  . CYS A 1 223 ? 103.684 114.656 117.532 1.00 69.28  ? 223 CYS A CB  1 
ATOM   1474 S  SG  . CYS A 1 223 ? 103.452 114.528 119.314 1.00 69.28  ? 223 CYS A SG  1 
ATOM   1475 N  N   . LEU A 1 224 ? 103.869 116.236 114.786 1.00 66.24  ? 224 LEU A N   1 
ATOM   1476 C  CA  . LEU A 1 224 ? 104.061 116.269 113.341 1.00 66.24  ? 224 LEU A CA  1 
ATOM   1477 C  C   . LEU A 1 224 ? 105.233 117.167 112.965 1.00 66.24  ? 224 LEU A C   1 
ATOM   1478 O  O   . LEU A 1 224 ? 106.056 116.809 112.112 1.00 66.24  ? 224 LEU A O   1 
ATOM   1479 C  CB  . LEU A 1 224 ? 102.777 116.746 112.663 1.00 66.24  ? 224 LEU A CB  1 
ATOM   1480 C  CG  . LEU A 1 224 ? 102.631 116.539 111.157 1.00 66.24  ? 224 LEU A CG  1 
ATOM   1481 C  CD1 . LEU A 1 224 ? 102.491 115.064 110.853 1.00 66.24  ? 224 LEU A CD1 1 
ATOM   1482 C  CD2 . LEU A 1 224 ? 101.440 117.309 110.628 1.00 66.24  ? 224 LEU A CD2 1 
ATOM   1483 N  N   . LEU A 1 225 ? 105.330 118.336 113.604 1.00 70.19  ? 225 LEU A N   1 
ATOM   1484 C  CA  . LEU A 1 225 ? 106.448 119.237 113.347 1.00 70.19  ? 225 LEU A CA  1 
ATOM   1485 C  C   . LEU A 1 225 ? 107.773 118.602 113.741 1.00 70.19  ? 225 LEU A C   1 
ATOM   1486 O  O   . LEU A 1 225 ? 108.775 118.757 113.037 1.00 70.19  ? 225 LEU A O   1 
ATOM   1487 C  CB  . LEU A 1 225 ? 106.247 120.552 114.099 1.00 70.19  ? 225 LEU A CB  1 
ATOM   1488 C  CG  . LEU A 1 225 ? 107.283 121.644 113.835 1.00 70.19  ? 225 LEU A CG  1 
ATOM   1489 C  CD1 . LEU A 1 225 ? 107.288 122.040 112.370 1.00 70.19  ? 225 LEU A CD1 1 
ATOM   1490 C  CD2 . LEU A 1 225 ? 107.026 122.847 114.721 1.00 70.19  ? 225 LEU A CD2 1 
ATOM   1491 N  N   . LEU A 1 226 ? 107.802 117.894 114.871 1.00 71.43  ? 226 LEU A N   1 
ATOM   1492 C  CA  . LEU A 1 226 ? 109.034 117.251 115.318 1.00 71.43  ? 226 LEU A CA  1 
ATOM   1493 C  C   . LEU A 1 226 ? 109.494 116.194 114.321 1.00 71.43  ? 226 LEU A C   1 
ATOM   1494 O  O   . LEU A 1 226 ? 110.681 116.123 113.970 1.00 71.43  ? 226 LEU A O   1 
ATOM   1495 C  CB  . LEU A 1 226 ? 108.818 116.634 116.698 1.00 71.43  ? 226 LEU A CB  1 
ATOM   1496 C  CG  . LEU A 1 226 ? 110.014 115.967 117.372 1.00 71.43  ? 226 LEU A CG  1 
ATOM   1497 C  CD1 . LEU A 1 226 ? 111.114 116.982 117.632 1.00 71.43  ? 226 LEU A CD1 1 
ATOM   1498 C  CD2 . LEU A 1 226 ? 109.584 115.290 118.663 1.00 71.43  ? 226 LEU A CD2 1 
ATOM   1499 N  N   . VAL A 1 227 ? 108.561 115.366 113.844 1.00 69.09  ? 227 VAL A N   1 
ATOM   1500 C  CA  . VAL A 1 227 ? 108.917 114.333 112.872 1.00 69.09  ? 227 VAL A CA  1 
ATOM   1501 C  C   . VAL A 1 227 ? 109.396 114.965 111.571 1.00 69.09  ? 227 VAL A C   1 
ATOM   1502 O  O   . VAL A 1 227 ? 110.369 114.504 110.959 1.00 69.09  ? 227 VAL A O   1 
ATOM   1503 C  CB  . VAL A 1 227 ? 107.731 113.379 112.639 1.00 69.09  ? 227 VAL A CB  1 
ATOM   1504 C  CG1 . VAL A 1 227 ? 108.070 112.377 111.561 1.00 69.09  ? 227 VAL A CG1 1 
ATOM   1505 C  CG2 . VAL A 1 227 ? 107.370 112.661 113.923 1.00 69.09  ? 227 VAL A CG2 1 
ATOM   1506 N  N   . TRP A 1 228 ? 108.727 116.032 111.127 1.00 71.56  ? 228 TRP A N   1 
ATOM   1507 C  CA  . TRP A 1 228 ? 109.151 116.701 109.901 1.00 71.56  ? 228 TRP A CA  1 
ATOM   1508 C  C   . TRP A 1 228 ? 110.527 117.337 110.058 1.00 71.56  ? 228 TRP A C   1 
ATOM   1509 O  O   . TRP A 1 228 ? 111.326 117.337 109.116 1.00 71.56  ? 228 TRP A O   1 
ATOM   1510 C  CB  . TRP A 1 228 ? 108.115 117.743 109.487 1.00 71.56  ? 228 TRP A CB  1 
ATOM   1511 C  CG  . TRP A 1 228 ? 107.060 117.181 108.597 1.00 71.56  ? 228 TRP A CG  1 
ATOM   1512 C  CD1 . TRP A 1 228 ? 105.776 116.877 108.937 1.00 71.56  ? 228 TRP A CD1 1 
ATOM   1513 C  CD2 . TRP A 1 228 ? 107.201 116.840 107.215 1.00 71.56  ? 228 TRP A CD2 1 
ATOM   1514 N  NE1 . TRP A 1 228 ? 105.106 116.372 107.852 1.00 71.56  ? 228 TRP A NE1 1 
ATOM   1515 C  CE2 . TRP A 1 228 ? 105.960 116.338 106.781 1.00 71.56  ? 228 TRP A CE2 1 
ATOM   1516 C  CE3 . TRP A 1 228 ? 108.256 116.913 106.302 1.00 71.56  ? 228 TRP A CE3 1 
ATOM   1517 C  CZ2 . TRP A 1 228 ? 105.745 115.910 105.475 1.00 71.56  ? 228 TRP A CZ2 1 
ATOM   1518 C  CZ3 . TRP A 1 228 ? 108.041 116.488 105.006 1.00 71.56  ? 228 TRP A CZ3 1 
ATOM   1519 C  CH2 . TRP A 1 228 ? 106.796 115.994 104.604 1.00 71.56  ? 228 TRP A CH2 1 
ATOM   1520 N  N   . LEU A 1 229 ? 110.822 117.890 111.235 1.00 76.66  ? 229 LEU A N   1 
ATOM   1521 C  CA  . LEU A 1 229 ? 112.143 118.463 111.470 1.00 76.66  ? 229 LEU A CA  1 
ATOM   1522 C  C   . LEU A 1 229 ? 113.223 117.391 111.451 1.00 76.66  ? 229 LEU A C   1 
ATOM   1523 O  O   . LEU A 1 229 ? 114.308 117.609 110.901 1.00 76.66  ? 229 LEU A O   1 
ATOM   1524 C  CB  . LEU A 1 229 ? 112.159 119.222 112.795 1.00 76.66  ? 229 LEU A CB  1 
ATOM   1525 C  CG  . LEU A 1 229 ? 111.815 120.707 112.685 1.00 76.66  ? 229 LEU A CG  1 
ATOM   1526 C  CD1 . LEU A 1 229 ? 111.865 121.372 114.046 1.00 76.66  ? 229 LEU A CD1 1 
ATOM   1527 C  CD2 . LEU A 1 229 ? 112.753 121.395 111.710 1.00 76.66  ? 229 LEU A CD2 1 
ATOM   1528 N  N   . VAL A 1 230 ? 112.949 116.228 112.049 1.00 76.97  ? 230 VAL A N   1 
ATOM   1529 C  CA  . VAL A 1 230 ? 113.913 115.129 111.984 1.00 76.97  ? 230 VAL A CA  1 
ATOM   1530 C  C   . VAL A 1 230 ? 114.148 114.711 110.537 1.00 76.97  ? 230 VAL A C   1 
ATOM   1531 O  O   . VAL A 1 230 ? 115.293 114.510 110.106 1.00 76.97  ? 230 VAL A O   1 
ATOM   1532 C  CB  . VAL A 1 230 ? 113.438 113.945 112.845 1.00 76.97  ? 230 VAL A CB  1 
ATOM   1533 C  CG1 . VAL A 1 230 ? 114.307 112.726 112.594 1.00 76.97  ? 230 VAL A CG1 1 
ATOM   1534 C  CG2 . VAL A 1 230 ? 113.461 114.319 114.311 1.00 76.97  ? 230 VAL A CG2 1 
ATOM   1535 N  N   . CYS A 1 231 ? 113.067 114.582 109.762 1.00 82.09  ? 231 CYS A N   1 
ATOM   1536 C  CA  . CYS A 1 231 ? 113.202 114.196 108.361 1.00 82.09  ? 231 CYS A CA  1 
ATOM   1537 C  C   . CYS A 1 231 ? 113.978 115.233 107.560 1.00 82.09  ? 231 CYS A C   1 
ATOM   1538 O  O   . CYS A 1 231 ? 114.752 114.873 106.667 1.00 82.09  ? 231 CYS A O   1 
ATOM   1539 C  CB  . CYS A 1 231 ? 111.821 113.973 107.744 1.00 82.09  ? 231 CYS A CB  1 
ATOM   1540 S  SG  . CYS A 1 231 ? 111.846 113.407 106.032 1.00 82.09  ? 231 CYS A SG  1 
ATOM   1541 N  N   . PHE A 1 232 ? 113.779 116.520 107.850 1.00 88.71  ? 232 PHE A N   1 
ATOM   1542 C  CA  . PHE A 1 232 ? 114.503 117.562 107.127 1.00 88.71  ? 232 PHE A CA  1 
ATOM   1543 C  C   . PHE A 1 232 ? 115.974 117.593 107.517 1.00 88.71  ? 232 PHE A C   1 
ATOM   1544 O  O   . PHE A 1 232 ? 116.838 117.852 106.672 1.00 88.71  ? 232 PHE A O   1 
ATOM   1545 C  CB  . PHE A 1 232 ? 113.859 118.925 107.375 1.00 88.71  ? 232 PHE A CB  1 
ATOM   1546 C  CG  . PHE A 1 232 ? 114.654 120.077 106.827 1.00 88.71  ? 232 PHE A CG  1 
ATOM   1547 C  CD1 . PHE A 1 232 ? 114.617 120.380 105.479 1.00 88.71  ? 232 PHE A CD1 1 
ATOM   1548 C  CD2 . PHE A 1 232 ? 115.437 120.857 107.661 1.00 88.71  ? 232 PHE A CD2 1 
ATOM   1549 C  CE1 . PHE A 1 232 ? 115.345 121.436 104.972 1.00 88.71  ? 232 PHE A CE1 1 
ATOM   1550 C  CE2 . PHE A 1 232 ? 116.166 121.914 107.159 1.00 88.71  ? 232 PHE A CE2 1 
ATOM   1551 C  CZ  . PHE A 1 232 ? 116.121 122.203 105.813 1.00 88.71  ? 232 PHE A CZ  1 
ATOM   1552 N  N   . PHE A 1 233 ? 116.281 117.355 108.794 1.00 93.22  ? 233 PHE A N   1 
ATOM   1553 C  CA  . PHE A 1 233 ? 117.675 117.383 109.223 1.00 93.22  ? 233 PHE A CA  1 
ATOM   1554 C  C   . PHE A 1 233 ? 118.437 116.158 108.740 1.00 93.22  ? 233 PHE A C   1 
ATOM   1555 O  O   . PHE A 1 233 ? 119.657 116.228 108.553 1.00 93.22  ? 233 PHE A O   1 
ATOM   1556 C  CB  . PHE A 1 233 ? 117.761 117.508 110.744 1.00 93.22  ? 233 PHE A CB  1 
ATOM   1557 C  CG  . PHE A 1 233 ? 117.635 118.921 111.242 1.00 93.22  ? 233 PHE A CG  1 
ATOM   1558 C  CD1 . PHE A 1 233 ? 118.438 119.925 110.725 1.00 93.22  ? 233 PHE A CD1 1 
ATOM   1559 C  CD2 . PHE A 1 233 ? 116.716 119.247 112.225 1.00 93.22  ? 233 PHE A CD2 1 
ATOM   1560 C  CE1 . PHE A 1 233 ? 118.326 121.226 111.178 1.00 93.22  ? 233 PHE A CE1 1 
ATOM   1561 C  CE2 . PHE A 1 233 ? 116.598 120.548 112.683 1.00 93.22  ? 233 PHE A CE2 1 
ATOM   1562 C  CZ  . PHE A 1 233 ? 117.405 121.537 112.159 1.00 93.22  ? 233 PHE A CZ  1 
ATOM   1563 N  N   . CYS A 1 234 ? 117.750 115.036 108.527 1.00 96.26  ? 234 CYS A N   1 
ATOM   1564 C  CA  . CYS A 1 234 ? 118.415 113.874 107.948 1.00 96.26  ? 234 CYS A CA  1 
ATOM   1565 C  C   . CYS A 1 234 ? 118.660 114.011 106.449 1.00 96.26  ? 234 CYS A C   1 
ATOM   1566 O  O   . CYS A 1 234 ? 119.349 113.164 105.873 1.00 96.26  ? 234 CYS A O   1 
ATOM   1567 C  CB  . CYS A 1 234 ? 117.609 112.606 108.226 1.00 96.26  ? 234 CYS A CB  1 
ATOM   1568 S  SG  . CYS A 1 234 ? 117.640 112.072 109.952 1.00 96.26  ? 234 CYS A SG  1 
ATOM   1569 N  N   . ILE A 1 235 ? 118.113 115.040 105.805 1.00 98.48  ? 235 ILE A N   1 
ATOM   1570 C  CA  . ILE A 1 235 ? 118.426 115.334 104.413 1.00 98.48  ? 235 ILE A CA  1 
ATOM   1571 C  C   . ILE A 1 235 ? 119.274 116.591 104.256 1.00 98.48  ? 235 ILE A C   1 
ATOM   1572 O  O   . ILE A 1 235 ? 119.906 116.768 103.201 1.00 98.48  ? 235 ILE A O   1 
ATOM   1573 C  CB  . ILE A 1 235 ? 117.138 115.444 103.568 1.00 98.48  ? 235 ILE A CB  1 
ATOM   1574 C  CG1 . ILE A 1 235 ? 116.232 114.241 103.824 1.00 98.48  ? 235 ILE A CG1 1 
ATOM   1575 C  CG2 . ILE A 1 235 ? 117.448 115.511 102.080 1.00 98.48  ? 235 ILE A CG2 1 
ATOM   1576 C  CD1 . ILE A 1 235 ? 114.991 114.229 102.968 1.00 98.48  ? 235 ILE A CD1 1 
ATOM   1577 N  N   . TRP A 1 236 ? 119.326 117.464 105.265 1.00 106.05 ? 236 TRP A N   1 
ATOM   1578 C  CA  . TRP A 1 236 ? 120.246 118.597 105.235 1.00 106.05 ? 236 TRP A CA  1 
ATOM   1579 C  C   . TRP A 1 236 ? 121.669 118.111 104.993 1.00 106.05 ? 236 TRP A C   1 
ATOM   1580 O  O   . TRP A 1 236 ? 122.364 118.596 104.094 1.00 106.05 ? 236 TRP A O   1 
ATOM   1581 C  CB  . TRP A 1 236 ? 120.167 119.355 106.566 1.00 106.05 ? 236 TRP A CB  1 
ATOM   1582 C  CG  . TRP A 1 236 ? 121.101 120.533 106.725 1.00 106.05 ? 236 TRP A CG  1 
ATOM   1583 C  CD1 . TRP A 1 236 ? 122.469 120.513 106.708 1.00 106.05 ? 236 TRP A CD1 1 
ATOM   1584 C  CD2 . TRP A 1 236 ? 120.730 121.878 107.061 1.00 106.05 ? 236 TRP A CD2 1 
ATOM   1585 N  NE1 . TRP A 1 236 ? 122.965 121.774 106.934 1.00 106.05 ? 236 TRP A NE1 1 
ATOM   1586 C  CE2 . TRP A 1 236 ? 121.919 122.629 107.165 1.00 106.05 ? 236 TRP A CE2 1 
ATOM   1587 C  CE3 . TRP A 1 236 ? 119.509 122.524 107.256 1.00 106.05 ? 236 TRP A CE3 1 
ATOM   1588 C  CZ2 . TRP A 1 236 ? 121.919 123.993 107.456 1.00 106.05 ? 236 TRP A CZ2 1 
ATOM   1589 C  CZ3 . TRP A 1 236 ? 119.509 123.880 107.547 1.00 106.05 ? 236 TRP A CZ3 1 
ATOM   1590 C  CH2 . TRP A 1 236 ? 120.708 124.598 107.643 1.00 106.05 ? 236 TRP A CH2 1 
ATOM   1591 N  N   . LYS A 1 237 ? 122.108 117.135 105.786 1.00 108.61 ? 237 LYS A N   1 
ATOM   1592 C  CA  . LYS A 1 237 ? 123.471 116.628 105.744 1.00 108.61 ? 237 LYS A CA  1 
ATOM   1593 C  C   . LYS A 1 237 ? 123.664 115.494 104.748 1.00 108.61 ? 237 LYS A C   1 
ATOM   1594 O  O   . LYS A 1 237 ? 124.806 115.074 104.527 1.00 108.61 ? 237 LYS A O   1 
ATOM   1595 C  CB  . LYS A 1 237 ? 123.897 116.153 107.137 1.00 108.61 ? 237 LYS A CB  1 
ATOM   1596 C  CG  . LYS A 1 237 ? 124.253 117.276 108.094 1.00 108.61 ? 237 LYS A CG  1 
ATOM   1597 C  CD  . LYS A 1 237 ? 123.029 117.788 108.835 1.00 108.61 ? 237 LYS A CD  1 
ATOM   1598 C  CE  . LYS A 1 237 ? 123.424 118.736 109.953 1.00 108.61 ? 237 LYS A CE  1 
ATOM   1599 N  NZ  . LYS A 1 237 ? 122.238 119.213 110.712 1.00 108.61 ? 237 LYS A NZ  1 
ATOM   1600 N  N   . GLY A 1 238 ? 122.590 114.984 104.153 1.00 114.18 ? 238 GLY A N   1 
ATOM   1601 C  CA  . GLY A 1 238 ? 122.700 113.902 103.196 1.00 114.18 ? 238 GLY A CA  1 
ATOM   1602 C  C   . GLY A 1 238 ? 123.242 112.627 103.806 1.00 114.18 ? 238 GLY A C   1 
ATOM   1603 O  O   . GLY A 1 238 ? 123.972 111.878 103.149 1.00 114.18 ? 238 GLY A O   1 
ATOM   1604 N  N   . VAL A 1 239 ? 122.898 112.373 105.069 1.00 117.35 ? 239 VAL A N   1 
ATOM   1605 C  CA  . VAL A 1 239 ? 123.385 111.177 105.746 1.00 117.35 ? 239 VAL A CA  1 
ATOM   1606 C  C   . VAL A 1 239 ? 122.747 109.952 105.107 1.00 117.35 ? 239 VAL A C   1 
ATOM   1607 O  O   . VAL A 1 239 ? 121.525 109.892 104.919 1.00 117.35 ? 239 VAL A O   1 
ATOM   1608 C  CB  . VAL A 1 239 ? 123.106 111.252 107.252 1.00 117.35 ? 239 VAL A CB  1 
ATOM   1609 C  CG1 . VAL A 1 239 ? 123.979 112.316 107.896 1.00 117.35 ? 239 VAL A CG1 1 
ATOM   1610 C  CG2 . VAL A 1 239 ? 121.642 111.546 107.519 1.00 117.35 ? 239 VAL A CG2 1 
ATOM   1611 N  N   . ARG A 1 240 ? 123.576 108.975 104.749 1.00 126.59 ? 240 ARG A N   1 
ATOM   1612 C  CA  . ARG A 1 240 ? 123.094 107.763 104.095 1.00 126.59 ? 240 ARG A CA  1 
ATOM   1613 C  C   . ARG A 1 240 ? 123.963 106.596 104.534 1.00 126.59 ? 240 ARG A C   1 
ATOM   1614 O  O   . ARG A 1 240 ? 125.162 106.574 104.240 1.00 126.59 ? 240 ARG A O   1 
ATOM   1615 C  CB  . ARG A 1 240 ? 123.119 107.913 102.572 1.00 126.59 ? 240 ARG A CB  1 
ATOM   1616 N  N   . SER A 1 241 ? 123.353 105.643 105.243 1.00 130.78 ? 241 SER A N   1 
ATOM   1617 C  CA  . SER A 1 241 ? 124.019 104.437 105.728 1.00 130.78 ? 241 SER A CA  1 
ATOM   1618 C  C   . SER A 1 241 ? 125.147 104.753 106.705 1.00 130.78 ? 241 SER A C   1 
ATOM   1619 O  O   . SER A 1 241 ? 125.449 105.921 106.971 1.00 130.78 ? 241 SER A O   1 
ATOM   1620 C  CB  . SER A 1 241 ? 124.551 103.605 104.557 1.00 130.78 ? 241 SER A CB  1 
ATOM   1621 O  OG  . SER A 1 241 ? 123.488 103.097 103.771 1.00 130.78 ? 241 SER A OG  1 
ATOM   1622 N  N   . THR A 1 242 ? 125.770 103.709 107.246 1.00 131.43 ? 242 THR A N   1 
ATOM   1623 C  CA  . THR A 1 242 ? 126.823 103.841 108.246 1.00 131.43 ? 242 THR A CA  1 
ATOM   1624 C  C   . THR A 1 242 ? 127.863 102.758 107.988 1.00 131.43 ? 242 THR A C   1 
ATOM   1625 O  O   . THR A 1 242 ? 127.779 102.006 107.014 1.00 131.43 ? 242 THR A O   1 
ATOM   1626 C  CB  . THR A 1 242 ? 126.266 103.732 109.670 1.00 131.43 ? 242 THR A CB  1 
ATOM   1627 O  OG1 . THR A 1 242 ? 125.536 102.507 109.801 1.00 131.43 ? 242 THR A OG1 1 
ATOM   1628 C  CG2 . THR A 1 242 ? 125.355 104.908 110.008 1.00 131.43 ? 242 THR A CG2 1 
ATOM   1629 N  N   . GLY A 1 243 ? 128.851 102.684 108.877 1.00 132.76 ? 243 GLY A N   1 
ATOM   1630 C  CA  . GLY A 1 243 ? 129.888 101.678 108.771 1.00 132.76 ? 243 GLY A CA  1 
ATOM   1631 C  C   . GLY A 1 243 ? 129.598 100.426 109.573 1.00 132.76 ? 243 GLY A C   1 
ATOM   1632 O  O   . GLY A 1 243 ? 129.670 99.312  109.045 1.00 132.76 ? 243 GLY A O   1 
ATOM   1633 N  N   . LYS A 1 244 ? 129.264 100.596 110.856 1.00 130.70 ? 244 LYS A N   1 
ATOM   1634 C  CA  . LYS A 1 244 ? 128.983 99.472  111.741 1.00 130.70 ? 244 LYS A CA  1 
ATOM   1635 C  C   . LYS A 1 244 ? 127.647 99.631  112.458 1.00 130.70 ? 244 LYS A C   1 
ATOM   1636 O  O   . LYS A 1 244 ? 127.460 99.069  113.541 1.00 130.70 ? 244 LYS A O   1 
ATOM   1637 C  CB  . LYS A 1 244 ? 130.108 99.292  112.764 1.00 130.70 ? 244 LYS A CB  1 
ATOM   1638 C  CG  . LYS A 1 244 ? 131.368 98.657  112.200 1.00 130.70 ? 244 LYS A CG  1 
ATOM   1639 C  CD  . LYS A 1 244 ? 132.406 98.433  113.286 1.00 130.70 ? 244 LYS A CD  1 
ATOM   1640 C  CE  . LYS A 1 244 ? 133.791 98.234  112.693 1.00 130.70 ? 244 LYS A CE  1 
ATOM   1641 N  NZ  . LYS A 1 244 ? 134.864 98.399  113.712 1.00 130.70 ? 244 LYS A NZ  1 
ATOM   1642 N  N   . VAL A 1 245 ? 126.719 100.391 111.882 1.00 126.32 ? 245 VAL A N   1 
ATOM   1643 C  CA  . VAL A 1 245 ? 125.395 100.575 112.465 1.00 126.32 ? 245 VAL A CA  1 
ATOM   1644 C  C   . VAL A 1 245 ? 124.286 100.079 111.546 1.00 126.32 ? 245 VAL A C   1 
ATOM   1645 O  O   . VAL A 1 245 ? 123.146 99.907  112.009 1.00 126.32 ? 245 VAL A O   1 
ATOM   1646 C  CB  . VAL A 1 245 ? 125.160 102.056 112.851 1.00 126.32 ? 245 VAL A CB  1 
ATOM   1647 C  CG1 . VAL A 1 245 ? 123.848 102.257 113.608 1.00 126.32 ? 245 VAL A CG1 1 
ATOM   1648 C  CG2 . VAL A 1 245 ? 126.335 102.588 113.660 1.00 126.32 ? 245 VAL A CG2 1 
ATOM   1649 N  N   . VAL A 1 246 ? 124.579 99.814  110.270 1.00 124.32 ? 246 VAL A N   1 
ATOM   1650 C  CA  . VAL A 1 246 ? 123.557 99.299  109.364 1.00 124.32 ? 246 VAL A CA  1 
ATOM   1651 C  C   . VAL A 1 246 ? 123.124 97.898  109.777 1.00 124.32 ? 246 VAL A C   1 
ATOM   1652 O  O   . VAL A 1 246 ? 121.944 97.548  109.672 1.00 124.32 ? 246 VAL A O   1 
ATOM   1653 C  CB  . VAL A 1 246 ? 124.049 99.336  107.905 1.00 124.32 ? 246 VAL A CB  1 
ATOM   1654 C  CG1 . VAL A 1 246 ? 124.303 100.765 107.470 1.00 124.32 ? 246 VAL A CG1 1 
ATOM   1655 C  CG2 . VAL A 1 246 ? 125.313 98.504  107.738 1.00 124.32 ? 246 VAL A CG2 1 
ATOM   1656 N  N   . TYR A 1 247 ? 124.057 97.076  110.259 1.00 125.93 ? 247 TYR A N   1 
ATOM   1657 C  CA  . TYR A 1 247 ? 123.690 95.729  110.679 1.00 125.93 ? 247 TYR A CA  1 
ATOM   1658 C  C   . TYR A 1 247 ? 122.906 95.719  111.983 1.00 125.93 ? 247 TYR A C   1 
ATOM   1659 O  O   . TYR A 1 247 ? 122.429 94.656  112.393 1.00 125.93 ? 247 TYR A O   1 
ATOM   1660 C  CB  . TYR A 1 247 ? 124.931 94.830  110.786 1.00 125.93 ? 247 TYR A CB  1 
ATOM   1661 C  CG  . TYR A 1 247 ? 125.910 95.161  111.892 1.00 125.93 ? 247 TYR A CG  1 
ATOM   1662 C  CD1 . TYR A 1 247 ? 125.690 94.737  113.198 1.00 125.93 ? 247 TYR A CD1 1 
ATOM   1663 C  CD2 . TYR A 1 247 ? 127.077 95.861  111.622 1.00 125.93 ? 247 TYR A CD2 1 
ATOM   1664 C  CE1 . TYR A 1 247 ? 126.588 95.027  114.206 1.00 125.93 ? 247 TYR A CE1 1 
ATOM   1665 C  CE2 . TYR A 1 247 ? 127.984 96.152  112.624 1.00 125.93 ? 247 TYR A CE2 1 
ATOM   1666 C  CZ  . TYR A 1 247 ? 127.733 95.734  113.913 1.00 125.93 ? 247 TYR A CZ  1 
ATOM   1667 O  OH  . TYR A 1 247 ? 128.633 96.023  114.913 1.00 125.93 ? 247 TYR A OH  1 
ATOM   1668 N  N   . PHE A 1 248 ? 122.773 96.866  112.648 1.00 118.73 ? 248 PHE A N   1 
ATOM   1669 C  CA  . PHE A 1 248 ? 121.823 97.025  113.740 1.00 118.73 ? 248 PHE A CA  1 
ATOM   1670 C  C   . PHE A 1 248 ? 120.503 97.615  113.260 1.00 118.73 ? 248 PHE A C   1 
ATOM   1671 O  O   . PHE A 1 248 ? 119.433 97.129  113.634 1.00 118.73 ? 248 PHE A O   1 
ATOM   1672 C  CB  . PHE A 1 248 ? 122.423 97.904  114.846 1.00 118.73 ? 248 PHE A CB  1 
ATOM   1673 C  CG  . PHE A 1 248 ? 121.397 98.528  115.755 1.00 118.73 ? 248 PHE A CG  1 
ATOM   1674 C  CD1 . PHE A 1 248 ? 120.925 99.811  115.522 1.00 118.73 ? 248 PHE A CD1 1 
ATOM   1675 C  CD2 . PHE A 1 248 ? 120.900 97.827  116.841 1.00 118.73 ? 248 PHE A CD2 1 
ATOM   1676 C  CE1 . PHE A 1 248 ? 119.981 100.380 116.355 1.00 118.73 ? 248 PHE A CE1 1 
ATOM   1677 C  CE2 . PHE A 1 248 ? 119.956 98.392  117.678 1.00 118.73 ? 248 PHE A CE2 1 
ATOM   1678 C  CZ  . PHE A 1 248 ? 119.496 99.670  117.434 1.00 118.73 ? 248 PHE A CZ  1 
ATOM   1679 N  N   . THR A 1 249 ? 120.564 98.654  112.423 1.00 116.66 ? 249 THR A N   1 
ATOM   1680 C  CA  . THR A 1 249 ? 119.347 99.329  111.983 1.00 116.66 ? 249 THR A CA  1 
ATOM   1681 C  C   . THR A 1 249 ? 118.493 98.444  111.085 1.00 116.66 ? 249 THR A C   1 
ATOM   1682 O  O   . THR A 1 249 ? 117.262 98.557  111.102 1.00 116.66 ? 249 THR A O   1 
ATOM   1683 C  CB  . THR A 1 249 ? 119.688 100.632 111.259 1.00 116.66 ? 249 THR A CB  1 
ATOM   1684 O  OG1 . THR A 1 249 ? 120.550 100.355 110.150 1.00 116.66 ? 249 THR A OG1 1 
ATOM   1685 C  CG2 . THR A 1 249 ? 120.375 101.602 112.204 1.00 116.66 ? 249 THR A CG2 1 
ATOM   1686 N  N   . ALA A 1 250 ? 119.112 97.570  110.291 1.00 112.29 ? 250 ALA A N   1 
ATOM   1687 C  CA  . ALA A 1 250 ? 118.363 96.692  109.404 1.00 112.29 ? 250 ALA A CA  1 
ATOM   1688 C  C   . ALA A 1 250 ? 118.013 95.353  110.035 1.00 112.29 ? 250 ALA A C   1 
ATOM   1689 O  O   . ALA A 1 250 ? 117.276 94.574  109.423 1.00 112.29 ? 250 ALA A O   1 
ATOM   1690 C  CB  . ALA A 1 250 ? 119.150 96.449  108.114 1.00 112.29 ? 250 ALA A CB  1 
ATOM   1691 N  N   . THR A 1 251 ? 118.518 95.063  111.234 1.00 105.94 ? 251 THR A N   1 
ATOM   1692 C  CA  . THR A 1 251 ? 118.243 93.789  111.883 1.00 105.94 ? 251 THR A CA  1 
ATOM   1693 C  C   . THR A 1 251 ? 117.416 93.918  113.154 1.00 105.94 ? 251 THR A C   1 
ATOM   1694 O  O   . THR A 1 251 ? 116.818 92.926  113.585 1.00 105.94 ? 251 THR A O   1 
ATOM   1695 C  CB  . THR A 1 251 ? 119.552 93.060  112.211 1.00 105.94 ? 251 THR A CB  1 
ATOM   1696 O  OG1 . THR A 1 251 ? 120.387 93.905  113.013 1.00 105.94 ? 251 THR A OG1 1 
ATOM   1697 C  CG2 . THR A 1 251 ? 120.288 92.693  110.935 1.00 105.94 ? 251 THR A CG2 1 
ATOM   1698 N  N   . PHE A 1 252 ? 117.378 95.103  113.774 1.00 95.43  ? 252 PHE A N   1 
ATOM   1699 C  CA  . PHE A 1 252 ? 116.525 95.286  114.947 1.00 95.43  ? 252 PHE A CA  1 
ATOM   1700 C  C   . PHE A 1 252 ? 115.045 95.119  114.623 1.00 95.43  ? 252 PHE A C   1 
ATOM   1701 O  O   . PHE A 1 252 ? 114.339 94.447  115.398 1.00 95.43  ? 252 PHE A O   1 
ATOM   1702 C  CB  . PHE A 1 252 ? 116.820 96.642  115.596 1.00 95.43  ? 252 PHE A CB  1 
ATOM   1703 C  CG  . PHE A 1 252 ? 115.871 97.004  116.699 1.00 95.43  ? 252 PHE A CG  1 
ATOM   1704 C  CD1 . PHE A 1 252 ? 115.742 96.194  117.813 1.00 95.43  ? 252 PHE A CD1 1 
ATOM   1705 C  CD2 . PHE A 1 252 ? 115.107 98.154  116.621 1.00 95.43  ? 252 PHE A CD2 1 
ATOM   1706 C  CE1 . PHE A 1 252 ? 114.868 96.524  118.828 1.00 95.43  ? 252 PHE A CE1 1 
ATOM   1707 C  CE2 . PHE A 1 252 ? 114.234 98.489  117.633 1.00 95.43  ? 252 PHE A CE2 1 
ATOM   1708 C  CZ  . PHE A 1 252 ? 114.113 97.673  118.738 1.00 95.43  ? 252 PHE A CZ  1 
ATOM   1709 N  N   . PRO A 1 253 ? 114.500 95.702  113.542 1.00 93.53  ? 253 PRO A N   1 
ATOM   1710 C  CA  . PRO A 1 253 ? 113.075 95.468  113.249 1.00 93.53  ? 253 PRO A CA  1 
ATOM   1711 C  C   . PRO A 1 253 ? 112.727 94.003  113.071 1.00 93.53  ? 253 PRO A C   1 
ATOM   1712 O  O   . PRO A 1 253 ? 111.657 93.569  113.510 1.00 93.53  ? 253 PRO A O   1 
ATOM   1713 C  CB  . PRO A 1 253 ? 112.851 96.265  111.957 1.00 93.53  ? 253 PRO A CB  1 
ATOM   1714 C  CG  . PRO A 1 253 ? 113.875 97.326  111.994 1.00 93.53  ? 253 PRO A CG  1 
ATOM   1715 C  CD  . PRO A 1 253 ? 115.079 96.695  112.619 1.00 93.53  ? 253 PRO A CD  1 
ATOM   1716 N  N   . PHE A 1 254 ? 113.610 93.220  112.451 1.00 89.08  ? 254 PHE A N   1 
ATOM   1717 C  CA  . PHE A 1 254 ? 113.312 91.807  112.243 1.00 89.08  ? 254 PHE A CA  1 
ATOM   1718 C  C   . PHE A 1 254 ? 113.325 91.038  113.557 1.00 89.08  ? 254 PHE A C   1 
ATOM   1719 O  O   . PHE A 1 254 ? 112.488 90.154  113.772 1.00 89.08  ? 254 PHE A O   1 
ATOM   1720 C  CB  . PHE A 1 254 ? 114.298 91.211  111.241 1.00 89.08  ? 254 PHE A CB  1 
ATOM   1721 C  CG  . PHE A 1 254 ? 114.038 91.634  109.826 1.00 89.08  ? 254 PHE A CG  1 
ATOM   1722 C  CD1 . PHE A 1 254 ? 113.106 90.968  109.050 1.00 89.08  ? 254 PHE A CD1 1 
ATOM   1723 C  CD2 . PHE A 1 254 ? 114.710 92.711  109.278 1.00 89.08  ? 254 PHE A CD2 1 
ATOM   1724 C  CE1 . PHE A 1 254 ? 112.860 91.362  107.750 1.00 89.08  ? 254 PHE A CE1 1 
ATOM   1725 C  CE2 . PHE A 1 254 ? 114.469 93.109  107.980 1.00 89.08  ? 254 PHE A CE2 1 
ATOM   1726 C  CZ  . PHE A 1 254 ? 113.543 92.434  107.215 1.00 89.08  ? 254 PHE A CZ  1 
ATOM   1727 N  N   . ALA A 1 255 ? 114.256 91.365  114.456 1.00 85.28  ? 255 ALA A N   1 
ATOM   1728 C  CA  . ALA A 1 255 ? 114.253 90.738  115.773 1.00 85.28  ? 255 ALA A CA  1 
ATOM   1729 C  C   . ALA A 1 255 ? 112.998 91.104  116.556 1.00 85.28  ? 255 ALA A C   1 
ATOM   1730 O  O   . ALA A 1 255 ? 112.399 90.247  117.219 1.00 85.28  ? 255 ALA A O   1 
ATOM   1731 C  CB  . ALA A 1 255 ? 115.508 91.136  116.547 1.00 85.28  ? 255 ALA A CB  1 
ATOM   1732 N  N   . MET A 1 256 ? 112.580 92.371  116.487 1.00 83.99  ? 256 MET A N   1 
ATOM   1733 C  CA  . MET A 1 256 ? 111.348 92.779  117.157 1.00 83.99  ? 256 MET A CA  1 
ATOM   1734 C  C   . MET A 1 256 ? 110.136 92.054  116.583 1.00 83.99  ? 256 MET A C   1 
ATOM   1735 O  O   . MET A 1 256 ? 109.241 91.642  117.328 1.00 83.99  ? 256 MET A O   1 
ATOM   1736 C  CB  . MET A 1 256 ? 111.172 94.293  117.055 1.00 83.99  ? 256 MET A CB  1 
ATOM   1737 C  CG  . MET A 1 256 ? 110.170 94.861  118.042 1.00 83.99  ? 256 MET A CG  1 
ATOM   1738 S  SD  . MET A 1 256 ? 110.802 95.038  119.715 1.00 83.99  ? 256 MET A SD  1 
ATOM   1739 C  CE  . MET A 1 256 ? 109.543 94.139  120.613 1.00 83.99  ? 256 MET A CE  1 
ATOM   1740 N  N   . LEU A 1 257 ? 110.089 91.891  115.260 1.00 82.03  ? 257 LEU A N   1 
ATOM   1741 C  CA  . LEU A 1 257 ? 108.991 91.152  114.647 1.00 82.03  ? 257 LEU A CA  1 
ATOM   1742 C  C   . LEU A 1 257 ? 109.007 89.689  115.070 1.00 82.03  ? 257 LEU A C   1 
ATOM   1743 O  O   . LEU A 1 257 ? 107.949 89.081  115.265 1.00 82.03  ? 257 LEU A O   1 
ATOM   1744 C  CB  . LEU A 1 257 ? 109.058 91.279  113.126 1.00 82.03  ? 257 LEU A CB  1 
ATOM   1745 C  CG  . LEU A 1 257 ? 108.562 92.612  112.563 1.00 82.03  ? 257 LEU A CG  1 
ATOM   1746 C  CD1 . LEU A 1 257 ? 108.945 92.762  111.102 1.00 82.03  ? 257 LEU A CD1 1 
ATOM   1747 C  CD2 . LEU A 1 257 ? 107.060 92.741  112.738 1.00 82.03  ? 257 LEU A CD2 1 
ATOM   1748 N  N   . LEU A 1 258 ? 110.198 89.102  115.211 1.00 79.34  ? 258 LEU A N   1 
ATOM   1749 C  CA  . LEU A 1 258 ? 110.284 87.726  115.692 1.00 79.34  ? 258 LEU A CA  1 
ATOM   1750 C  C   . LEU A 1 258 ? 109.753 87.603  117.115 1.00 79.34  ? 258 LEU A C   1 
ATOM   1751 O  O   . LEU A 1 258 ? 109.017 86.660  117.432 1.00 79.34  ? 258 LEU A O   1 
ATOM   1752 C  CB  . LEU A 1 258 ? 111.726 87.228  115.609 1.00 79.34  ? 258 LEU A CB  1 
ATOM   1753 C  CG  . LEU A 1 258 ? 111.984 85.777  116.022 1.00 79.34  ? 258 LEU A CG  1 
ATOM   1754 C  CD1 . LEU A 1 258 ? 112.894 85.102  115.014 1.00 79.34  ? 258 LEU A CD1 1 
ATOM   1755 C  CD2 . LEU A 1 258 ? 112.590 85.704  117.415 1.00 79.34  ? 258 LEU A CD2 1 
ATOM   1756 N  N   . VAL A 1 259 ? 110.112 88.549  117.987 1.00 77.95  ? 259 VAL A N   1 
ATOM   1757 C  CA  . VAL A 1 259 ? 109.584 88.530  119.352 1.00 77.95  ? 259 VAL A CA  1 
ATOM   1758 C  C   . VAL A 1 259 ? 108.071 88.702  119.344 1.00 77.95  ? 259 VAL A C   1 
ATOM   1759 O  O   . VAL A 1 259 ? 107.352 88.048  120.111 1.00 77.95  ? 259 VAL A O   1 
ATOM   1760 C  CB  . VAL A 1 259 ? 110.269 89.600  120.222 1.00 77.95  ? 259 VAL A CB  1 
ATOM   1761 C  CG1 . VAL A 1 259 ? 109.868 89.428  121.676 1.00 77.95  ? 259 VAL A CG1 1 
ATOM   1762 C  CG2 . VAL A 1 259 ? 111.772 89.493  120.101 1.00 77.95  ? 259 VAL A CG2 1 
ATOM   1763 N  N   . LEU A 1 260 ? 107.563 89.588  118.483 1.00 77.05  ? 260 LEU A N   1 
ATOM   1764 C  CA  . LEU A 1 260 ? 106.121 89.796  118.396 1.00 77.05  ? 260 LEU A CA  1 
ATOM   1765 C  C   . LEU A 1 260 ? 105.404 88.530  117.944 1.00 77.05  ? 260 LEU A C   1 
ATOM   1766 O  O   . LEU A 1 260 ? 104.345 88.185  118.479 1.00 77.05  ? 260 LEU A O   1 
ATOM   1767 C  CB  . LEU A 1 260 ? 105.813 90.951  117.444 1.00 77.05  ? 260 LEU A CB  1 
ATOM   1768 C  CG  . LEU A 1 260 ? 105.962 92.367  118.001 1.00 77.05  ? 260 LEU A CG  1 
ATOM   1769 C  CD1 . LEU A 1 260 ? 105.796 93.390  116.889 1.00 77.05  ? 260 LEU A CD1 1 
ATOM   1770 C  CD2 . LEU A 1 260 ? 104.964 92.617  119.119 1.00 77.05  ? 260 LEU A CD2 1 
ATOM   1771 N  N   . LEU A 1 261 ? 105.961 87.831  116.953 1.00 74.60  ? 261 LEU A N   1 
ATOM   1772 C  CA  . LEU A 1 261 ? 105.362 86.578  116.504 1.00 74.60  ? 261 LEU A CA  1 
ATOM   1773 C  C   . LEU A 1 261 ? 105.387 85.525  117.602 1.00 74.60  ? 261 LEU A C   1 
ATOM   1774 O  O   . LEU A 1 261 ? 104.409 84.792  117.795 1.00 74.60  ? 261 LEU A O   1 
ATOM   1775 C  CB  . LEU A 1 261 ? 106.072 86.065  115.250 1.00 74.60  ? 261 LEU A CB  1 
ATOM   1776 C  CG  . LEU A 1 261 ? 105.620 84.675  114.794 1.00 74.60  ? 261 LEU A CG  1 
ATOM   1777 C  CD1 . LEU A 1 261 ? 105.478 84.621  113.304 1.00 74.60  ? 261 LEU A CD1 1 
ATOM   1778 C  CD2 . LEU A 1 261 ? 106.622 83.616  115.234 1.00 74.60  ? 261 LEU A CD2 1 
ATOM   1779 N  N   . VAL A 1 262 ? 106.509 85.410  118.316 1.00 70.39  ? 262 VAL A N   1 
ATOM   1780 C  CA  . VAL A 1 262 ? 106.583 84.415  119.381 1.00 70.39  ? 262 VAL A CA  1 
ATOM   1781 C  C   . VAL A 1 262 ? 105.577 84.734  120.480 1.00 70.39  ? 262 VAL A C   1 
ATOM   1782 O  O   . VAL A 1 262 ? 104.966 83.825  121.056 1.00 70.39  ? 262 VAL A O   1 
ATOM   1783 C  CB  . VAL A 1 262 ? 108.019 84.313  119.927 1.00 70.39  ? 262 VAL A CB  1 
ATOM   1784 C  CG1 . VAL A 1 262 ? 108.074 83.366  121.113 1.00 70.39  ? 262 VAL A CG1 1 
ATOM   1785 C  CG2 . VAL A 1 262 ? 108.958 83.834  118.837 1.00 70.39  ? 262 VAL A CG2 1 
ATOM   1786 N  N   . ARG A 1 263 ? 105.381 86.017  120.788 1.00 71.37  ? 263 ARG A N   1 
ATOM   1787 C  CA  . ARG A 1 263 ? 104.366 86.395  121.766 1.00 71.37  ? 263 ARG A CA  1 
ATOM   1788 C  C   . ARG A 1 263 ? 102.964 86.068  121.266 1.00 71.37  ? 263 ARG A C   1 
ATOM   1789 O  O   . ARG A 1 263 ? 102.143 85.516  122.007 1.00 71.37  ? 263 ARG A O   1 
ATOM   1790 C  CB  . ARG A 1 263 ? 104.481 87.884  122.095 1.00 71.37  ? 263 ARG A CB  1 
ATOM   1791 C  CG  . ARG A 1 263 ? 103.276 88.448  122.831 1.00 71.37  ? 263 ARG A CG  1 
ATOM   1792 C  CD  . ARG A 1 263 ? 103.251 87.992  124.279 1.00 71.37  ? 263 ARG A CD  1 
ATOM   1793 N  NE  . ARG A 1 263 ? 102.534 86.735  124.451 1.00 71.37  ? 263 ARG A NE  1 
ATOM   1794 C  CZ  . ARG A 1 263 ? 102.211 86.216  125.627 1.00 71.37  ? 263 ARG A CZ  1 
ATOM   1795 N  NH1 . ARG A 1 263 ? 102.519 86.824  126.759 1.00 71.37  ? 263 ARG A NH1 1 
ATOM   1796 N  NH2 . ARG A 1 263 ? 101.564 85.055  125.668 1.00 71.37  ? 263 ARG A NH2 1 
ATOM   1797 N  N   . GLY A 1 264 ? 102.672 86.404  120.008 1.00 70.22  ? 264 GLY A N   1 
ATOM   1798 C  CA  . GLY A 1 264 ? 101.325 86.213  119.493 1.00 70.22  ? 264 GLY A CA  1 
ATOM   1799 C  C   . GLY A 1 264 ? 100.932 84.753  119.370 1.00 70.22  ? 264 GLY A C   1 
ATOM   1800 O  O   . GLY A 1 264 ? 99.829  84.361  119.760 1.00 70.22  ? 264 GLY A O   1 
ATOM   1801 N  N   . LEU A 1 265 ? 101.833 83.924  118.836 1.00 69.07  ? 265 LEU A N   1 
ATOM   1802 C  CA  . LEU A 1 265 ? 101.498 82.530  118.565 1.00 69.07  ? 265 LEU A CA  1 
ATOM   1803 C  C   . LEU A 1 265 ? 101.261 81.721  119.832 1.00 69.07  ? 265 LEU A C   1 
ATOM   1804 O  O   . LEU A 1 265 ? 100.684 80.633  119.755 1.00 69.07  ? 265 LEU A O   1 
ATOM   1805 C  CB  . LEU A 1 265 ? 102.604 81.872  117.741 1.00 69.07  ? 265 LEU A CB  1 
ATOM   1806 C  CG  . LEU A 1 265 ? 102.655 82.199  116.249 1.00 69.07  ? 265 LEU A CG  1 
ATOM   1807 C  CD1 . LEU A 1 265 ? 103.682 81.326  115.555 1.00 69.07  ? 265 LEU A CD1 1 
ATOM   1808 C  CD2 . LEU A 1 265 ? 101.290 82.020  115.616 1.00 69.07  ? 265 LEU A CD2 1 
ATOM   1809 N  N   . THR A 1 266 ? 101.686 82.223  120.991 1.00 70.74  ? 266 THR A N   1 
ATOM   1810 C  CA  . THR A 1 266 ? 101.567 81.504  122.251 1.00 70.74  ? 266 THR A CA  1 
ATOM   1811 C  C   . THR A 1 266 ? 100.391 81.985  123.096 1.00 70.74  ? 266 THR A C   1 
ATOM   1812 O  O   . THR A 1 266 ? 100.307 81.645  124.280 1.00 70.74  ? 266 THR A O   1 
ATOM   1813 C  CB  . THR A 1 266 ? 102.870 81.615  123.044 1.00 70.74  ? 266 THR A CB  1 
ATOM   1814 O  OG1 . THR A 1 266 ? 103.209 82.997  123.214 1.00 70.74  ? 266 THR A OG1 1 
ATOM   1815 C  CG2 . THR A 1 266 ? 103.999 80.909  122.314 1.00 70.74  ? 266 THR A CG2 1 
ATOM   1816 N  N   . LEU A 1 267 ? 99.472  82.777  122.505 1.00 71.87  ? 267 LEU A N   1 
ATOM   1817 C  CA  . LEU A 1 267 ? 98.311  83.300  123.207 1.00 71.87  ? 267 LEU A CA  1 
ATOM   1818 C  C   . LEU A 1 267 ? 97.072  82.466  122.901 1.00 71.87  ? 267 LEU A C   1 
ATOM   1819 O  O   . LEU A 1 267 ? 96.932  81.933  121.796 1.00 71.87  ? 267 LEU A O   1 
ATOM   1820 C  CB  . LEU A 1 267 ? 98.053  84.756  122.812 1.00 71.87  ? 267 LEU A CB  1 
ATOM   1821 C  CG  . LEU A 1 267 ? 98.833  85.801  123.609 1.00 71.87  ? 267 LEU A CG  1 
ATOM   1822 C  CD1 . LEU A 1 267 ? 98.771  87.150  122.926 1.00 71.87  ? 267 LEU A CD1 1 
ATOM   1823 C  CD2 . LEU A 1 267 ? 98.310  85.894  125.031 1.00 71.87  ? 267 LEU A CD2 1 
ATOM   1824 N  N   . PRO A 1 268 ? 96.159  82.333  123.864 1.00 74.49  ? 268 PRO A N   1 
ATOM   1825 C  CA  . PRO A 1 268 ? 94.943  81.550  123.621 1.00 74.49  ? 268 PRO A CA  1 
ATOM   1826 C  C   . PRO A 1 268 ? 94.101  82.160  122.512 1.00 74.49  ? 268 PRO A C   1 
ATOM   1827 O  O   . PRO A 1 268 ? 94.054  83.378  122.333 1.00 74.49  ? 268 PRO A O   1 
ATOM   1828 C  CB  . PRO A 1 268 ? 94.212  81.600  124.968 1.00 74.49  ? 268 PRO A CB  1 
ATOM   1829 C  CG  . PRO A 1 268 ? 95.263  81.947  125.963 1.00 74.49  ? 268 PRO A CG  1 
ATOM   1830 C  CD  . PRO A 1 268 ? 96.222  82.836  125.245 1.00 74.49  ? 268 PRO A CD  1 
ATOM   1831 N  N   . GLY A 1 269 ? 93.435  81.291  121.757 1.00 72.75  ? 269 GLY A N   1 
ATOM   1832 C  CA  . GLY A 1 269 ? 92.604  81.736  120.660 1.00 72.75  ? 269 GLY A CA  1 
ATOM   1833 C  C   . GLY A 1 269 ? 93.343  82.105  119.399 1.00 72.75  ? 269 GLY A C   1 
ATOM   1834 O  O   . GLY A 1 269 ? 92.726  82.644  118.476 1.00 72.75  ? 269 GLY A O   1 
ATOM   1835 N  N   . ALA A 1 270 ? 94.648  81.842  119.329 1.00 69.99  ? 270 ALA A N   1 
ATOM   1836 C  CA  . ALA A 1 270 ? 95.392  82.135  118.111 1.00 69.99  ? 270 ALA A CA  1 
ATOM   1837 C  C   . ALA A 1 270 ? 94.991  81.211  116.971 1.00 69.99  ? 270 ALA A C   1 
ATOM   1838 O  O   . ALA A 1 270 ? 95.068  81.604  115.801 1.00 69.99  ? 270 ALA A O   1 
ATOM   1839 C  CB  . ALA A 1 270 ? 96.893  82.033  118.373 1.00 69.99  ? 270 ALA A CB  1 
ATOM   1840 N  N   . GLY A 1 271 ? 94.567  79.985  117.286 1.00 69.89  ? 271 GLY A N   1 
ATOM   1841 C  CA  . GLY A 1 271 ? 94.149  79.066  116.240 1.00 69.89  ? 271 GLY A CA  1 
ATOM   1842 C  C   . GLY A 1 271 ? 92.937  79.561  115.475 1.00 69.89  ? 271 GLY A C   1 
ATOM   1843 O  O   . GLY A 1 271 ? 92.878  79.449  114.248 1.00 69.89  ? 271 GLY A O   1 
ATOM   1844 N  N   . ALA A 1 272 ? 91.955  80.116  116.189 1.00 69.59  ? 272 ALA A N   1 
ATOM   1845 C  CA  . ALA A 1 272 ? 90.779  80.672  115.529 1.00 69.59  ? 272 ALA A CA  1 
ATOM   1846 C  C   . ALA A 1 272 ? 91.158  81.843  114.631 1.00 69.59  ? 272 ALA A C   1 
ATOM   1847 O  O   . ALA A 1 272 ? 90.637  81.982  113.519 1.00 69.59  ? 272 ALA A O   1 
ATOM   1848 C  CB  . ALA A 1 272 ? 89.746  81.099  116.571 1.00 69.59  ? 272 ALA A CB  1 
ATOM   1849 N  N   . GLY A 1 273 ? 92.067  82.700  115.099 1.00 67.92  ? 273 GLY A N   1 
ATOM   1850 C  CA  . GLY A 1 273 ? 92.527  83.801  114.269 1.00 67.92  ? 273 GLY A CA  1 
ATOM   1851 C  C   . GLY A 1 273 ? 93.253  83.331  113.024 1.00 67.92  ? 273 GLY A C   1 
ATOM   1852 O  O   . GLY A 1 273 ? 93.070  83.888  111.940 1.00 67.92  ? 273 GLY A O   1 
ATOM   1853 N  N   . ILE A 1 274 ? 94.083  82.294  113.159 1.00 69.72  ? 274 ILE A N   1 
ATOM   1854 C  CA  . ILE A 1 274 ? 94.791  81.750  112.002 1.00 69.72  ? 274 ILE A CA  1 
ATOM   1855 C  C   . ILE A 1 274 ? 93.807  81.142  111.008 1.00 69.72  ? 274 ILE A C   1 
ATOM   1856 O  O   . ILE A 1 274 ? 93.941  81.317  109.790 1.00 69.72  ? 274 ILE A O   1 
ATOM   1857 C  CB  . ILE A 1 274 ? 95.851  80.728  112.456 1.00 69.72  ? 274 ILE A CB  1 
ATOM   1858 C  CG1 . ILE A 1 274 ? 96.966  81.430  113.232 1.00 69.72  ? 274 ILE A CG1 1 
ATOM   1859 C  CG2 . ILE A 1 274 ? 96.431  79.987  111.263 1.00 69.72  ? 274 ILE A CG2 1 
ATOM   1860 C  CD1 . ILE A 1 274 ? 97.906  80.482  113.929 1.00 69.72  ? 274 ILE A CD1 1 
ATOM   1861 N  N   . LYS A 1 275 ? 92.807  80.414  111.511 1.00 72.35  ? 275 LYS A N   1 
ATOM   1862 C  CA  . LYS A 1 275 ? 91.798  79.827  110.635 1.00 72.35  ? 275 LYS A CA  1 
ATOM   1863 C  C   . LYS A 1 275 ? 90.997  80.906  109.915 1.00 72.35  ? 275 LYS A C   1 
ATOM   1864 O  O   . LYS A 1 275 ? 90.663  80.761  108.734 1.00 72.35  ? 275 LYS A O   1 
ATOM   1865 C  CB  . LYS A 1 275 ? 90.876  78.923  111.448 1.00 72.35  ? 275 LYS A CB  1 
ATOM   1866 C  CG  . LYS A 1 275 ? 89.873  78.142  110.631 1.00 72.35  ? 275 LYS A CG  1 
ATOM   1867 C  CD  . LYS A 1 275 ? 89.016  77.273  111.532 1.00 72.35  ? 275 LYS A CD  1 
ATOM   1868 C  CE  . LYS A 1 275 ? 89.821  76.115  112.102 1.00 72.35  ? 275 LYS A CE  1 
ATOM   1869 N  NZ  . LYS A 1 275 ? 90.233  75.142  111.054 1.00 72.35  ? 275 LYS A NZ  1 
ATOM   1870 N  N   . PHE A 1 276 ? 90.672  81.992  110.618 1.00 68.70  ? 276 PHE A N   1 
ATOM   1871 C  CA  . PHE A 1 276 ? 90.010  83.132  109.993 1.00 68.70  ? 276 PHE A CA  1 
ATOM   1872 C  C   . PHE A 1 276 ? 90.893  83.755  108.919 1.00 68.70  ? 276 PHE A C   1 
ATOM   1873 O  O   . PHE A 1 276 ? 90.405  84.169  107.862 1.00 68.70  ? 276 PHE A O   1 
ATOM   1874 C  CB  . PHE A 1 276 ? 89.645  84.152  111.076 1.00 68.70  ? 276 PHE A CB  1 
ATOM   1875 C  CG  . PHE A 1 276 ? 88.996  85.408  110.562 1.00 68.70  ? 276 PHE A CG  1 
ATOM   1876 C  CD1 . PHE A 1 276 ? 87.620  85.548  110.586 1.00 68.70  ? 276 PHE A CD1 1 
ATOM   1877 C  CD2 . PHE A 1 276 ? 89.761  86.471  110.107 1.00 68.70  ? 276 PHE A CD2 1 
ATOM   1878 C  CE1 . PHE A 1 276 ? 87.019  86.705  110.131 1.00 68.70  ? 276 PHE A CE1 1 
ATOM   1879 C  CE2 . PHE A 1 276 ? 89.165  87.629  109.650 1.00 68.70  ? 276 PHE A CE2 1 
ATOM   1880 C  CZ  . PHE A 1 276 ? 87.793  87.747  109.665 1.00 68.70  ? 276 PHE A CZ  1 
ATOM   1881 N  N   . TYR A 1 277 ? 92.197  83.828  109.178 1.00 66.97  ? 277 TYR A N   1 
ATOM   1882 C  CA  . TYR A 1 277 ? 93.142  84.453  108.263 1.00 66.97  ? 277 TYR A CA  1 
ATOM   1883 C  C   . TYR A 1 277 ? 93.449  83.599  107.038 1.00 66.97  ? 277 TYR A C   1 
ATOM   1884 O  O   . TYR A 1 277 ? 93.817  84.152  105.997 1.00 66.97  ? 277 TYR A O   1 
ATOM   1885 C  CB  . TYR A 1 277 ? 94.423  84.785  109.037 1.00 66.97  ? 277 TYR A CB  1 
ATOM   1886 C  CG  . TYR A 1 277 ? 95.607  85.238  108.216 1.00 66.97  ? 277 TYR A CG  1 
ATOM   1887 C  CD1 . TYR A 1 277 ? 95.545  86.387  107.445 1.00 66.97  ? 277 TYR A CD1 1 
ATOM   1888 C  CD2 . TYR A 1 277 ? 96.809  84.549  108.266 1.00 66.97  ? 277 TYR A CD2 1 
ATOM   1889 C  CE1 . TYR A 1 277 ? 96.632  86.810  106.713 1.00 66.97  ? 277 TYR A CE1 1 
ATOM   1890 C  CE2 . TYR A 1 277 ? 97.900  84.966  107.539 1.00 66.97  ? 277 TYR A CE2 1 
ATOM   1891 C  CZ  . TYR A 1 277 ? 97.807  86.098  106.765 1.00 66.97  ? 277 TYR A CZ  1 
ATOM   1892 O  OH  . TYR A 1 277 ? 98.894  86.520  106.038 1.00 66.97  ? 277 TYR A OH  1 
ATOM   1893 N  N   . LEU A 1 278 ? 93.296  82.277  107.124 1.00 71.88  ? 278 LEU A N   1 
ATOM   1894 C  CA  . LEU A 1 278 ? 93.679  81.377  106.040 1.00 71.88  ? 278 LEU A CA  1 
ATOM   1895 C  C   . LEU A 1 278 ? 92.501  80.849  105.232 1.00 71.88  ? 278 LEU A C   1 
ATOM   1896 O  O   . LEU A 1 278 ? 92.489  80.983  104.005 1.00 71.88  ? 278 LEU A O   1 
ATOM   1897 C  CB  . LEU A 1 278 ? 94.487  80.195  106.597 1.00 71.88  ? 278 LEU A CB  1 
ATOM   1898 C  CG  . LEU A 1 278 ? 95.911  80.477  107.080 1.00 71.88  ? 278 LEU A CG  1 
ATOM   1899 C  CD1 . LEU A 1 278 ? 96.535  79.214  107.643 1.00 71.88  ? 278 LEU A CD1 1 
ATOM   1900 C  CD2 . LEU A 1 278 ? 96.769  81.046  105.962 1.00 71.88  ? 278 LEU A CD2 1 
ATOM   1901 N  N   . TYR A 1 279 ? 91.514  80.243  105.883 1.00 79.42  ? 279 TYR A N   1 
ATOM   1902 C  CA  . TYR A 1 279 ? 90.436  79.574  105.163 1.00 79.42  ? 279 TYR A CA  1 
ATOM   1903 C  C   . TYR A 1 279 ? 89.547  80.597  104.461 1.00 79.42  ? 279 TYR A C   1 
ATOM   1904 O  O   . TYR A 1 279 ? 89.057  81.532  105.108 1.00 79.42  ? 279 TYR A O   1 
ATOM   1905 C  CB  . TYR A 1 279 ? 89.602  78.728  106.123 1.00 79.42  ? 279 TYR A CB  1 
ATOM   1906 C  CG  . TYR A 1 279 ? 90.219  77.390  106.468 1.00 79.42  ? 279 TYR A CG  1 
ATOM   1907 C  CD1 . TYR A 1 279 ? 91.557  77.289  106.825 1.00 79.42  ? 279 TYR A CD1 1 
ATOM   1908 C  CD2 . TYR A 1 279 ? 89.459  76.230  106.449 1.00 79.42  ? 279 TYR A CD2 1 
ATOM   1909 C  CE1 . TYR A 1 279 ? 92.122  76.072  107.145 1.00 79.42  ? 279 TYR A CE1 1 
ATOM   1910 C  CE2 . TYR A 1 279 ? 90.015  75.007  106.769 1.00 79.42  ? 279 TYR A CE2 1 
ATOM   1911 C  CZ  . TYR A 1 279 ? 91.347  74.935  107.116 1.00 79.42  ? 279 TYR A CZ  1 
ATOM   1912 O  OH  . TYR A 1 279 ? 91.905  73.719  107.435 1.00 79.42  ? 279 TYR A OH  1 
ATOM   1913 N  N   . PRO A 1 280 ? 89.303  80.454  103.155 1.00 81.85  ? 280 PRO A N   1 
ATOM   1914 C  CA  . PRO A 1 280 ? 88.537  81.474  102.430 1.00 81.85  ? 280 PRO A CA  1 
ATOM   1915 C  C   . PRO A 1 280 ? 87.041  81.203  102.374 1.00 81.85  ? 280 PRO A C   1 
ATOM   1916 O  O   . PRO A 1 280 ? 86.596  80.058  102.501 1.00 81.85  ? 280 PRO A O   1 
ATOM   1917 C  CB  . PRO A 1 280 ? 89.157  81.428  101.031 1.00 81.85  ? 280 PRO A CB  1 
ATOM   1918 C  CG  . PRO A 1 280 ? 89.582  79.997  100.870 1.00 81.85  ? 280 PRO A CG  1 
ATOM   1919 C  CD  . PRO A 1 280 ? 89.820  79.414  102.249 1.00 81.85  ? 280 PRO A CD  1 
ATOM   1920 N  N   . ASP A 1 281 ? 86.259  82.265  102.185 1.00 91.35  ? 281 ASP A N   1 
ATOM   1921 C  CA  . ASP A 1 281 ? 84.824  82.169  101.943 1.00 91.35  ? 281 ASP A CA  1 
ATOM   1922 C  C   . ASP A 1 281 ? 84.562  82.477  100.474 1.00 91.35  ? 281 ASP A C   1 
ATOM   1923 O  O   . ASP A 1 281 ? 84.814  83.598  100.018 1.00 91.35  ? 281 ASP A O   1 
ATOM   1924 C  CB  . ASP A 1 281 ? 84.052  83.134  102.842 1.00 91.35  ? 281 ASP A CB  1 
ATOM   1925 C  CG  . ASP A 1 281 ? 82.591  82.757  102.984 1.00 91.35  ? 281 ASP A CG  1 
ATOM   1926 O  OD1 . ASP A 1 281 ? 81.818  83.567  103.537 1.00 91.35  ? 281 ASP A OD1 1 
ATOM   1927 O  OD2 . ASP A 1 281 ? 82.214  81.653  102.541 1.00 91.35  ? 281 ASP A OD2 1 
ATOM   1928 N  N   . ILE A 1 282 ? 84.051  81.486  99.740  1.00 93.81  ? 282 ILE A N   1 
ATOM   1929 C  CA  . ILE A 1 282 ? 83.918  81.618  98.293  1.00 93.81  ? 282 ILE A CA  1 
ATOM   1930 C  C   . ILE A 1 282 ? 82.856  82.635  97.895  1.00 93.81  ? 282 ILE A C   1 
ATOM   1931 O  O   . ILE A 1 282 ? 82.899  83.159  96.776  1.00 93.81  ? 282 ILE A O   1 
ATOM   1932 C  CB  . ILE A 1 282 ? 83.613  80.248  97.660  1.00 93.81  ? 282 ILE A CB  1 
ATOM   1933 C  CG1 . ILE A 1 282 ? 82.283  79.701  98.181  1.00 93.81  ? 282 ILE A CG1 1 
ATOM   1934 C  CG2 . ILE A 1 282 ? 84.739  79.267  97.947  1.00 93.81  ? 282 ILE A CG2 1 
ATOM   1935 C  CD1 . ILE A 1 282 ? 81.796  78.475  97.441  1.00 93.81  ? 282 ILE A CD1 1 
ATOM   1936 N  N   . THR A 1 283 ? 81.897  82.928  98.777  1.00 92.63  ? 283 THR A N   1 
ATOM   1937 C  CA  . THR A 1 283 ? 80.845  83.882  98.437  1.00 92.63  ? 283 THR A CA  1 
ATOM   1938 C  C   . THR A 1 283 ? 81.408  85.283  98.236  1.00 92.63  ? 283 THR A C   1 
ATOM   1939 O  O   . THR A 1 283 ? 80.979  86.009  97.331  1.00 92.63  ? 283 THR A O   1 
ATOM   1940 C  CB  . THR A 1 283 ? 79.772  83.890  99.527  1.00 92.63  ? 283 THR A CB  1 
ATOM   1941 O  OG1 . THR A 1 283 ? 79.277  82.560  99.723  1.00 92.63  ? 283 THR A OG1 1 
ATOM   1942 C  CG2 . THR A 1 283 ? 78.620  84.803  99.136  1.00 92.63  ? 283 THR A CG2 1 
ATOM   1943 N  N   . ARG A 1 284 ? 82.377  85.678  99.065  1.00 89.16  ? 284 ARG A N   1 
ATOM   1944 C  CA  . ARG A 1 284 ? 82.918  87.031  99.000  1.00 89.16  ? 284 ARG A CA  1 
ATOM   1945 C  C   . ARG A 1 284 ? 83.662  87.290  97.696  1.00 89.16  ? 284 ARG A C   1 
ATOM   1946 O  O   . ARG A 1 284 ? 83.881  88.452  97.339  1.00 89.16  ? 284 ARG A O   1 
ATOM   1947 C  CB  . ARG A 1 284 ? 83.833  87.270  100.206 1.00 89.16  ? 284 ARG A CB  1 
ATOM   1948 C  CG  . ARG A 1 284 ? 84.429  88.667  100.308 1.00 89.16  ? 284 ARG A CG  1 
ATOM   1949 C  CD  . ARG A 1 284 ? 83.343  89.703  100.538 1.00 89.16  ? 284 ARG A CD  1 
ATOM   1950 N  NE  . ARG A 1 284 ? 82.602  89.448  101.767 1.00 89.16  ? 284 ARG A NE  1 
ATOM   1951 C  CZ  . ARG A 1 284 ? 82.987  89.845  102.971 1.00 89.16  ? 284 ARG A CZ  1 
ATOM   1952 N  NH1 . ARG A 1 284 ? 84.093  90.548  103.144 1.00 89.16  ? 284 ARG A NH1 1 
ATOM   1953 N  NH2 . ARG A 1 284 ? 82.242  89.535  104.027 1.00 89.16  ? 284 ARG A NH2 1 
ATOM   1954 N  N   . LEU A 1 285 ? 84.027  86.237  96.961  1.00 88.14  ? 285 LEU A N   1 
ATOM   1955 C  CA  . LEU A 1 285 ? 84.749  86.410  95.705  1.00 88.14  ? 285 LEU A CA  1 
ATOM   1956 C  C   . LEU A 1 285 ? 83.921  87.128  94.648  1.00 88.14  ? 285 LEU A C   1 
ATOM   1957 O  O   . LEU A 1 285 ? 84.487  87.623  93.669  1.00 88.14  ? 285 LEU A O   1 
ATOM   1958 C  CB  . LEU A 1 285 ? 85.208  85.054  95.161  1.00 88.14  ? 285 LEU A CB  1 
ATOM   1959 C  CG  . LEU A 1 285 ? 86.532  84.463  95.660  1.00 88.14  ? 285 LEU A CG  1 
ATOM   1960 C  CD1 . LEU A 1 285 ? 87.699  85.358  95.271  1.00 88.14  ? 285 LEU A CD1 1 
ATOM   1961 C  CD2 . LEU A 1 285 ? 86.521  84.202  97.160  1.00 88.14  ? 285 LEU A CD2 1 
ATOM   1962 N  N   . GLU A 1 286 ? 82.602  87.194  94.820  1.00 91.65  ? 286 GLU A N   1 
ATOM   1963 C  CA  . GLU A 1 286 ? 81.726  87.852  93.862  1.00 91.65  ? 286 GLU A CA  1 
ATOM   1964 C  C   . GLU A 1 286 ? 81.613  89.354  94.088  1.00 91.65  ? 286 GLU A C   1 
ATOM   1965 O  O   . GLU A 1 286 ? 81.007  90.044  93.262  1.00 91.65  ? 286 GLU A O   1 
ATOM   1966 C  CB  . GLU A 1 286 ? 80.331  87.226  93.916  1.00 91.65  ? 286 GLU A CB  1 
ATOM   1967 C  CG  . GLU A 1 286 ? 80.283  85.791  93.432  1.00 91.65  ? 286 GLU A CG  1 
ATOM   1968 C  CD  . GLU A 1 286 ? 78.894  85.199  93.519  1.00 91.65  ? 286 GLU A CD  1 
ATOM   1969 O  OE1 . GLU A 1 286 ? 77.997  85.868  94.072  1.00 91.65  ? 286 GLU A OE1 1 
ATOM   1970 O  OE2 . GLU A 1 286 ? 78.700  84.063  93.039  1.00 91.65  ? 286 GLU A OE2 1 
ATOM   1971 N  N   . ASP A 1 287 ? 82.175  89.872  95.180  1.00 85.69  ? 287 ASP A N   1 
ATOM   1972 C  CA  . ASP A 1 287 ? 82.165  91.297  95.496  1.00 85.69  ? 287 ASP A CA  1 
ATOM   1973 C  C   . ASP A 1 287 ? 83.401  91.969  94.912  1.00 85.69  ? 287 ASP A C   1 
ATOM   1974 O  O   . ASP A 1 287 ? 84.521  91.511  95.161  1.00 85.69  ? 287 ASP A O   1 
ATOM   1975 C  CB  . ASP A 1 287 ? 82.120  91.518  97.000  1.00 85.69  ? 287 ASP A CB  1 
ATOM   1976 C  CG  . ASP A 1 287 ? 81.669  92.915  97.370  1.00 85.69  ? 287 ASP A CG  1 
ATOM   1977 O  OD1 . ASP A 1 287 ? 81.004  93.566  96.537  1.00 85.69  ? 287 ASP A OD1 1 
ATOM   1978 O  OD2 . ASP A 1 287 ? 81.977  93.363  98.494  1.00 85.69  ? 287 ASP A OD2 1 
ATOM   1979 N  N   . PRO A 1 288 ? 83.238  93.031  94.122  1.00 79.93  ? 288 PRO A N   1 
ATOM   1980 C  CA  . PRO A 1 288 ? 84.411  93.706  93.541  1.00 79.93  ? 288 PRO A CA  1 
ATOM   1981 C  C   . PRO A 1 288 ? 85.392  94.231  94.575  1.00 79.93  ? 288 PRO A C   1 
ATOM   1982 O  O   . PRO A 1 288 ? 86.576  94.406  94.253  1.00 79.93  ? 288 PRO A O   1 
ATOM   1983 C  CB  . PRO A 1 288 ? 83.789  94.871  92.753  1.00 79.93  ? 288 PRO A CB  1 
ATOM   1984 C  CG  . PRO A 1 288 ? 82.290  94.621  92.742  1.00 79.93  ? 288 PRO A CG  1 
ATOM   1985 C  CD  . PRO A 1 288 ? 82.034  93.272  93.318  1.00 79.93  ? 288 PRO A CD  1 
ATOM   1986 N  N   . GLN A 1 289 ? 84.929  94.506  95.796  1.00 77.40  ? 289 GLN A N   1 
ATOM   1987 C  CA  . GLN A 1 289 ? 85.755  95.200  96.778  1.00 77.40  ? 289 GLN A CA  1 
ATOM   1988 C  C   . GLN A 1 289 ? 86.987  94.386  97.153  1.00 77.40  ? 289 GLN A C   1 
ATOM   1989 O  O   . GLN A 1 289 ? 88.094  94.927  97.246  1.00 77.40  ? 289 GLN A O   1 
ATOM   1990 C  CB  . GLN A 1 289 ? 84.925  95.523  98.020  1.00 77.40  ? 289 GLN A CB  1 
ATOM   1991 C  CG  . GLN A 1 289 ? 85.453  96.695  98.824  1.00 77.40  ? 289 GLN A CG  1 
ATOM   1992 C  CD  . GLN A 1 289 ? 85.639  97.938  97.978  1.00 77.40  ? 289 GLN A CD  1 
ATOM   1993 O  OE1 . GLN A 1 289 ? 86.757  98.419  97.796  1.00 77.40  ? 289 GLN A OE1 1 
ATOM   1994 N  NE2 . GLN A 1 289 ? 84.541  98.464  97.451  1.00 77.40  ? 289 GLN A NE2 1 
ATOM   1995 N  N   . VAL A 1 290 ? 86.814  93.083  97.387  1.00 72.43  ? 290 VAL A N   1 
ATOM   1996 C  CA  . VAL A 1 290 ? 87.948  92.253  97.781  1.00 72.43  ? 290 VAL A CA  1 
ATOM   1997 C  C   . VAL A 1 290 ? 88.968  92.172  96.652  1.00 72.43  ? 290 VAL A C   1 
ATOM   1998 O  O   . VAL A 1 290 ? 90.180  92.276  96.880  1.00 72.43  ? 290 VAL A O   1 
ATOM   1999 C  CB  . VAL A 1 290 ? 87.468  90.859  98.230  1.00 72.43  ? 290 VAL A CB  1 
ATOM   2000 C  CG1 . VAL A 1 290 ? 86.659  90.178  97.141  1.00 72.43  ? 290 VAL A CG1 1 
ATOM   2001 C  CG2 . VAL A 1 290 ? 88.649  90.001  98.637  1.00 72.43  ? 290 VAL A CG2 1 
ATOM   2002 N  N   . TRP A 1 291 ? 88.495  92.017  95.415  1.00 71.90  ? 291 TRP A N   1 
ATOM   2003 C  CA  . TRP A 1 291 ? 89.404  91.924  94.281  1.00 71.90  ? 291 TRP A CA  1 
ATOM   2004 C  C   . TRP A 1 291 ? 90.155  93.226  94.052  1.00 71.90  ? 291 TRP A C   1 
ATOM   2005 O  O   . TRP A 1 291 ? 91.315  93.200  93.629  1.00 71.90  ? 291 TRP A O   1 
ATOM   2006 C  CB  . TRP A 1 291 ? 88.634  91.526  93.022  1.00 71.90  ? 291 TRP A CB  1 
ATOM   2007 C  CG  . TRP A 1 291 ? 88.307  90.070  92.969  1.00 71.90  ? 291 TRP A CG  1 
ATOM   2008 C  CD1 . TRP A 1 291 ? 87.242  89.448  93.551  1.00 71.90  ? 291 TRP A CD1 1 
ATOM   2009 C  CD2 . TRP A 1 291 ? 89.057  89.047  92.308  1.00 71.90  ? 291 TRP A CD2 1 
ATOM   2010 N  NE1 . TRP A 1 291 ? 87.280  88.102  93.289  1.00 71.90  ? 291 TRP A NE1 1 
ATOM   2011 C  CE2 . TRP A 1 291 ? 88.385  87.829  92.528  1.00 71.90  ? 291 TRP A CE2 1 
ATOM   2012 C  CE3 . TRP A 1 291 ? 90.232  89.042  91.550  1.00 71.90  ? 291 TRP A CE3 1 
ATOM   2013 C  CZ2 . TRP A 1 291 ? 88.848  86.620  92.019  1.00 71.90  ? 291 TRP A CZ2 1 
ATOM   2014 C  CZ3 . TRP A 1 291 ? 90.689  87.841  91.045  1.00 71.90  ? 291 TRP A CZ3 1 
ATOM   2015 C  CH2 . TRP A 1 291 ? 89.998  86.647  91.281  1.00 71.90  ? 291 TRP A CH2 1 
ATOM   2016 N  N   . ILE A 1 292 ? 89.522  94.370  94.316  1.00 71.41  ? 292 ILE A N   1 
ATOM   2017 C  CA  . ILE A 1 292 ? 90.195  95.643  94.082  1.00 71.41  ? 292 ILE A CA  1 
ATOM   2018 C  C   . ILE A 1 292 ? 91.073  96.079  95.252  1.00 71.41  ? 292 ILE A C   1 
ATOM   2019 O  O   . ILE A 1 292 ? 92.013  96.860  95.048  1.00 71.41  ? 292 ILE A O   1 
ATOM   2020 C  CB  . ILE A 1 292 ? 89.183  96.751  93.736  1.00 71.41  ? 292 ILE A CB  1 
ATOM   2021 C  CG1 . ILE A 1 292 ? 89.886  97.901  93.009  1.00 71.41  ? 292 ILE A CG1 1 
ATOM   2022 C  CG2 . ILE A 1 292 ? 88.477  97.253  94.984  1.00 71.41  ? 292 ILE A CG2 1 
ATOM   2023 C  CD1 . ILE A 1 292 ? 89.007  98.644  92.038  1.00 71.41  ? 292 ILE A CD1 1 
ATOM   2024 N  N   . ASP A 1 293 ? 90.810  95.597  96.466  1.00 69.92  ? 293 ASP A N   1 
ATOM   2025 C  CA  . ASP A 1 293 ? 91.655  95.928  97.603  1.00 69.92  ? 293 ASP A CA  1 
ATOM   2026 C  C   . ASP A 1 293 ? 92.709  94.865  97.891  1.00 69.92  ? 293 ASP A C   1 
ATOM   2027 O  O   . ASP A 1 293 ? 93.534  95.055  98.789  1.00 69.92  ? 293 ASP A O   1 
ATOM   2028 C  CB  . ASP A 1 293 ? 90.788  96.233  98.840  1.00 69.92  ? 293 ASP A CB  1 
ATOM   2029 C  CG  . ASP A 1 293 ? 90.283  94.988  99.579  1.00 69.92  ? 293 ASP A CG  1 
ATOM   2030 O  OD1 . ASP A 1 293 ? 90.729  93.850  99.331  1.00 69.92  ? 293 ASP A OD1 1 
ATOM   2031 O  OD2 . ASP A 1 293 ? 89.407  95.167  100.450 1.00 69.92  ? 293 ASP A OD2 1 
ATOM   2032 N  N   . ALA A 1 294 ? 92.697  93.749  97.161  1.00 65.54  ? 294 ALA A N   1 
ATOM   2033 C  CA  . ALA A 1 294 ? 93.792  92.792  97.253  1.00 65.54  ? 294 ALA A CA  1 
ATOM   2034 C  C   . ALA A 1 294 ? 94.886  93.067  96.231  1.00 65.54  ? 294 ALA A C   1 
ATOM   2035 O  O   . ALA A 1 294 ? 96.068  92.868  96.524  1.00 65.54  ? 294 ALA A O   1 
ATOM   2036 C  CB  . ALA A 1 294 ? 93.264  91.368  97.078  1.00 65.54  ? 294 ALA A CB  1 
ATOM   2037 N  N   . GLY A 1 295 ? 94.517  93.521  95.037  1.00 64.11  ? 295 GLY A N   1 
ATOM   2038 C  CA  . GLY A 1 295 ? 95.502  93.823  94.019  1.00 64.11  ? 295 GLY A CA  1 
ATOM   2039 C  C   . GLY A 1 295 ? 96.217  95.141  94.187  1.00 64.11  ? 295 GLY A C   1 
ATOM   2040 O  O   . GLY A 1 295 ? 97.217  95.377  93.503  1.00 64.11  ? 295 GLY A O   1 
ATOM   2041 N  N   . THR A 1 296 ? 95.734  96.005  95.078  1.00 63.76  ? 296 THR A N   1 
ATOM   2042 C  CA  . THR A 1 296 ? 96.389  97.276  95.352  1.00 63.76  ? 296 THR A CA  1 
ATOM   2043 C  C   . THR A 1 296 ? 97.237  97.252  96.612  1.00 63.76  ? 296 THR A C   1 
ATOM   2044 O  O   . THR A 1 296 ? 98.146  98.078  96.743  1.00 63.76  ? 296 THR A O   1 
ATOM   2045 C  CB  . THR A 1 296 ? 95.353  98.398  95.468  1.00 63.76  ? 296 THR A CB  1 
ATOM   2046 O  OG1 . THR A 1 296 ? 94.356  98.034  96.431  1.00 63.76  ? 296 THR A OG1 1 
ATOM   2047 C  CG2 . THR A 1 296 ? 94.693  98.633  94.134  1.00 63.76  ? 296 THR A CG2 1 
ATOM   2048 N  N   . GLN A 1 297 ? 96.974  96.323  97.533  1.00 63.55  ? 297 GLN A N   1 
ATOM   2049 C  CA  . GLN A 1 297 ? 97.843  96.176  98.694  1.00 63.55  ? 297 GLN A CA  1 
ATOM   2050 C  C   . GLN A 1 297 ? 99.256  95.805  98.268  1.00 63.55  ? 297 GLN A C   1 
ATOM   2051 O  O   . GLN A 1 297 ? 100.235 96.302  98.835  1.00 63.55  ? 297 GLN A O   1 
ATOM   2052 C  CB  . GLN A 1 297 ? 97.271  95.126  99.645  1.00 63.55  ? 297 GLN A CB  1 
ATOM   2053 C  CG  . GLN A 1 297 ? 98.206  94.723  100.768 1.00 63.55  ? 297 GLN A CG  1 
ATOM   2054 C  CD  . GLN A 1 297 ? 98.618  95.895  101.636 1.00 63.55  ? 297 GLN A CD  1 
ATOM   2055 O  OE1 . GLN A 1 297 ? 97.899  96.886  101.743 1.00 63.55  ? 297 GLN A OE1 1 
ATOM   2056 N  NE2 . GLN A 1 297 ? 99.781  95.786  102.263 1.00 63.55  ? 297 GLN A NE2 1 
ATOM   2057 N  N   . ILE A 1 298 ? 99.381  94.938  97.262  1.00 63.78  ? 298 ILE A N   1 
ATOM   2058 C  CA  . ILE A 1 298 ? 100.694 94.576  96.740  1.00 63.78  ? 298 ILE A CA  1 
ATOM   2059 C  C   . ILE A 1 298 ? 101.357 95.766  96.064  1.00 63.78  ? 298 ILE A C   1 
ATOM   2060 O  O   . ILE A 1 298 ? 102.545 96.033  96.277  1.00 63.78  ? 298 ILE A O   1 
ATOM   2061 C  CB  . ILE A 1 298 ? 100.565 93.381  95.782  1.00 63.78  ? 298 ILE A CB  1 
ATOM   2062 C  CG1 . ILE A 1 298 ? 100.525 92.089  96.579  1.00 63.78  ? 298 ILE A CG1 1 
ATOM   2063 C  CG2 . ILE A 1 298 ? 101.704 93.353  94.776  1.00 63.78  ? 298 ILE A CG2 1 
ATOM   2064 C  CD1 . ILE A 1 298 ? 100.177 90.927  95.758  1.00 63.78  ? 298 ILE A CD1 1 
ATOM   2065 N  N   . PHE A 1 299 ? 100.609 96.495  95.238  1.00 64.32  ? 299 PHE A N   1 
ATOM   2066 C  CA  . PHE A 1 299 ? 101.170 97.655  94.558  1.00 64.32  ? 299 PHE A CA  1 
ATOM   2067 C  C   . PHE A 1 299 ? 101.617 98.723  95.546  1.00 64.32  ? 299 PHE A C   1 
ATOM   2068 O  O   . PHE A 1 299 ? 102.557 99.470  95.257  1.00 64.32  ? 299 PHE A O   1 
ATOM   2069 C  CB  . PHE A 1 299 ? 100.146 98.235  93.581  1.00 64.32  ? 299 PHE A CB  1 
ATOM   2070 C  CG  . PHE A 1 299 ? 99.913  97.387  92.359  1.00 64.32  ? 299 PHE A CG  1 
ATOM   2071 C  CD1 . PHE A 1 299 ? 100.380 96.085  92.291  1.00 64.32  ? 299 PHE A CD1 1 
ATOM   2072 C  CD2 . PHE A 1 299 ? 99.205  97.890  91.283  1.00 64.32  ? 299 PHE A CD2 1 
ATOM   2073 C  CE1 . PHE A 1 299 ? 100.158 95.309  91.171  1.00 64.32  ? 299 PHE A CE1 1 
ATOM   2074 C  CE2 . PHE A 1 299 ? 98.978  97.115  90.163  1.00 64.32  ? 299 PHE A CE2 1 
ATOM   2075 C  CZ  . PHE A 1 299 ? 99.457  95.825  90.107  1.00 64.32  ? 299 PHE A CZ  1 
ATOM   2076 N  N   . PHE A 1 300 ? 100.956 98.813  96.700  1.00 63.03  ? 300 PHE A N   1 
ATOM   2077 C  CA  . PHE A 1 300 ? 101.385 99.722  97.754  1.00 63.03  ? 300 PHE A CA  1 
ATOM   2078 C  C   . PHE A 1 300 ? 102.621 99.197  98.479  1.00 63.03  ? 300 PHE A C   1 
ATOM   2079 O  O   . PHE A 1 300 ? 103.547 99.964  98.760  1.00 63.03  ? 300 PHE A O   1 
ATOM   2080 C  CB  . PHE A 1 300 ? 100.227 99.942  98.733  1.00 63.03  ? 300 PHE A CB  1 
ATOM   2081 C  CG  . PHE A 1 300 ? 100.549 100.869 99.872  1.00 63.03  ? 300 PHE A CG  1 
ATOM   2082 C  CD1 . PHE A 1 300 ? 100.373 102.235 99.738  1.00 63.03  ? 300 PHE A CD1 1 
ATOM   2083 C  CD2 . PHE A 1 300 ? 100.998 100.373 101.084 1.00 63.03  ? 300 PHE A CD2 1 
ATOM   2084 C  CE1 . PHE A 1 300 ? 100.657 103.087 100.783 1.00 63.03  ? 300 PHE A CE1 1 
ATOM   2085 C  CE2 . PHE A 1 300 ? 101.285 101.222 102.131 1.00 63.03  ? 300 PHE A CE2 1 
ATOM   2086 C  CZ  . PHE A 1 300 ? 101.112 102.579 101.981 1.00 63.03  ? 300 PHE A CZ  1 
ATOM   2087 N  N   . SER A 1 301 ? 102.648 97.910  98.810  1.00 64.27  ? 301 SER A N   1 
ATOM   2088 C  CA  . SER A 1 301 ? 103.769 97.361  99.583  1.00 64.27  ? 301 SER A CA  1 
ATOM   2089 C  C   . SER A 1 301 ? 105.080 97.327  98.810  1.00 64.27  ? 301 SER A C   1 
ATOM   2090 O  O   . SER A 1 301 ? 106.142 97.558  99.385  1.00 64.27  ? 301 SER A O   1 
ATOM   2091 C  CB  . SER A 1 301 ? 103.433 95.958  100.090 1.00 64.27  ? 301 SER A CB  1 
ATOM   2092 O  OG  . SER A 1 301 ? 102.361 95.996  101.014 1.00 64.27  ? 301 SER A OG  1 
ATOM   2093 N  N   . TYR A 1 302 ? 105.015 97.042  97.516  1.00 70.67  ? 302 TYR A N   1 
ATOM   2094 C  CA  . TYR A 1 302 ? 106.218 96.933  96.706  1.00 70.67  ? 302 TYR A CA  1 
ATOM   2095 C  C   . TYR A 1 302 ? 106.672 98.275  96.151  1.00 70.67  ? 302 TYR A C   1 
ATOM   2096 O  O   . TYR A 1 302 ? 107.600 98.311  95.338  1.00 70.67  ? 302 TYR A O   1 
ATOM   2097 C  CB  . TYR A 1 302 ? 105.994 95.940  95.562  1.00 70.67  ? 302 TYR A CB  1 
ATOM   2098 C  CG  . TYR A 1 302 ? 106.120 94.489  95.967  1.00 70.67  ? 302 TYR A CG  1 
ATOM   2099 C  CD1 . TYR A 1 302 ? 105.259 93.932  96.902  1.00 70.67  ? 302 TYR A CD1 1 
ATOM   2100 C  CD2 . TYR A 1 302 ? 107.096 93.675  95.412  1.00 70.67  ? 302 TYR A CD2 1 
ATOM   2101 C  CE1 . TYR A 1 302 ? 105.369 92.610  97.276  1.00 70.67  ? 302 TYR A CE1 1 
ATOM   2102 C  CE2 . TYR A 1 302 ? 107.214 92.353  95.780  1.00 70.67  ? 302 TYR A CE2 1 
ATOM   2103 C  CZ  . TYR A 1 302 ? 106.348 91.826  96.712  1.00 70.67  ? 302 TYR A CZ  1 
ATOM   2104 O  OH  . TYR A 1 302 ? 106.460 90.509  97.081  1.00 70.67  ? 302 TYR A OH  1 
ATOM   2105 N  N   . ALA A 1 303 ? 106.033 99.372  96.569  1.00 71.31  ? 303 ALA A N   1 
ATOM   2106 C  CA  . ALA A 1 303 ? 106.392 100.725 96.140  1.00 71.31  ? 303 ALA A CA  1 
ATOM   2107 C  C   . ALA A 1 303 ? 106.349 100.860 94.622  1.00 71.31  ? 303 ALA A C   1 
ATOM   2108 O  O   . ALA A 1 303 ? 107.181 101.536 94.015  1.00 71.31  ? 303 ALA A O   1 
ATOM   2109 C  CB  . ALA A 1 303 ? 107.761 101.137 96.683  1.00 71.31  ? 303 ALA A CB  1 
ATOM   2110 N  N   . ILE A 1 304 ? 105.367 100.223 94.008  1.00 71.98  ? 304 ILE A N   1 
ATOM   2111 C  CA  . ILE A 1 304 ? 105.231 100.234 92.558  1.00 71.98  ? 304 ILE A CA  1 
ATOM   2112 C  C   . ILE A 1 304 ? 104.524 101.510 92.120  1.00 71.98  ? 304 ILE A C   1 
ATOM   2113 O  O   . ILE A 1 304 ? 103.647 102.034 92.817  1.00 71.98  ? 304 ILE A O   1 
ATOM   2114 C  CB  . ILE A 1 304 ? 104.480 98.971  92.089  1.00 71.98  ? 304 ILE A CB  1 
ATOM   2115 C  CG1 . ILE A 1 304 ? 105.172 97.720  92.623  1.00 71.98  ? 304 ILE A CG1 1 
ATOM   2116 C  CG2 . ILE A 1 304 ? 104.412 98.905  90.579  1.00 71.98  ? 304 ILE A CG2 1 
ATOM   2117 C  CD1 . ILE A 1 304 ? 104.467 96.438  92.265  1.00 71.98  ? 304 ILE A CD1 1 
ATOM   2118 N  N   . CYS A 1 305 ? 104.928 102.026 90.957  1.00 76.48  ? 305 CYS A N   1 
ATOM   2119 C  CA  . CYS A 1 305 ? 104.311 103.192 90.328  1.00 76.48  ? 305 CYS A CA  1 
ATOM   2120 C  C   . CYS A 1 305 ? 104.463 104.458 91.166  1.00 76.48  ? 305 CYS A C   1 
ATOM   2121 O  O   . CYS A 1 305 ? 103.598 105.335 91.139  1.00 76.48  ? 305 CYS A O   1 
ATOM   2122 C  CB  . CYS A 1 305 ? 102.832 102.940 90.017  1.00 76.48  ? 305 CYS A CB  1 
ATOM   2123 S  SG  . CYS A 1 305 ? 102.520 101.489 88.989  1.00 76.48  ? 305 CYS A SG  1 
ATOM   2124 N  N   . LEU A 1 306 ? 105.563 104.569 91.909  1.00 74.70  ? 306 LEU A N   1 
ATOM   2125 C  CA  . LEU A 1 306 ? 105.869 105.770 92.670  1.00 74.70  ? 306 LEU A CA  1 
ATOM   2126 C  C   . LEU A 1 306 ? 107.060 106.541 92.125  1.00 74.70  ? 306 LEU A C   1 
ATOM   2127 O  O   . LEU A 1 306 ? 107.265 107.692 92.525  1.00 74.70  ? 306 LEU A O   1 
ATOM   2128 C  CB  . LEU A 1 306 ? 106.139 105.419 94.139  1.00 74.70  ? 306 LEU A CB  1 
ATOM   2129 C  CG  . LEU A 1 306 ? 104.939 104.998 94.979  1.00 74.70  ? 306 LEU A CG  1 
ATOM   2130 C  CD1 . LEU A 1 306 ? 105.342 104.888 96.431  1.00 74.70  ? 306 LEU A CD1 1 
ATOM   2131 C  CD2 . LEU A 1 306 ? 103.809 105.985 94.813  1.00 74.70  ? 306 LEU A CD2 1 
ATOM   2132 N  N   . GLY A 1 307 ? 107.845 105.947 91.231  1.00 81.82  ? 307 GLY A N   1 
ATOM   2133 C  CA  . GLY A 1 307 ? 109.066 106.559 90.759  1.00 81.82  ? 307 GLY A CA  1 
ATOM   2134 C  C   . GLY A 1 307 ? 110.262 106.355 91.659  1.00 81.82  ? 307 GLY A C   1 
ATOM   2135 O  O   . GLY A 1 307 ? 111.363 106.796 91.308  1.00 81.82  ? 307 GLY A O   1 
ATOM   2136 N  N   . ALA A 1 308 ? 110.084 105.704 92.810  1.00 84.48  ? 308 ALA A N   1 
ATOM   2137 C  CA  . ALA A 1 308 ? 111.203 105.468 93.714  1.00 84.48  ? 308 ALA A CA  1 
ATOM   2138 C  C   . ALA A 1 308 ? 112.114 104.360 93.202  1.00 84.48  ? 308 ALA A C   1 
ATOM   2139 O  O   . ALA A 1 308 ? 113.342 104.470 93.291  1.00 84.48  ? 308 ALA A O   1 
ATOM   2140 C  CB  . ALA A 1 308 ? 110.684 105.132 95.111  1.00 84.48  ? 308 ALA A CB  1 
ATOM   2141 N  N   . MET A 1 309 ? 111.536 103.283 92.667  1.00 86.58  ? 309 MET A N   1 
ATOM   2142 C  CA  . MET A 1 309 ? 112.336 102.137 92.247  1.00 86.58  ? 309 MET A CA  1 
ATOM   2143 C  C   . MET A 1 309 ? 113.095 102.416 90.956  1.00 86.58  ? 309 MET A C   1 
ATOM   2144 O  O   . MET A 1 309 ? 114.254 102.005 90.812  1.00 86.58  ? 309 MET A O   1 
ATOM   2145 C  CB  . MET A 1 309 ? 111.442 100.911 92.088  1.00 86.58  ? 309 MET A CB  1 
ATOM   2146 C  CG  . MET A 1 309 ? 110.832 100.465 93.392  1.00 86.58  ? 309 MET A CG  1 
ATOM   2147 S  SD  . MET A 1 309 ? 112.082 99.932  94.567  1.00 86.58  ? 309 MET A SD  1 
ATOM   2148 C  CE  . MET A 1 309 ? 111.078 99.717  96.027  1.00 86.58  ? 309 MET A CE  1 
ATOM   2149 N  N   . THR A 1 310 ? 112.460 103.103 90.007  1.00 86.47  ? 310 THR A N   1 
ATOM   2150 C  CA  . THR A 1 310 ? 113.133 103.452 88.764  1.00 86.47  ? 310 THR A CA  1 
ATOM   2151 C  C   . THR A 1 310 ? 114.282 104.425 88.980  1.00 86.47  ? 310 THR A C   1 
ATOM   2152 O  O   . THR A 1 310 ? 115.105 104.594 88.075  1.00 86.47  ? 310 THR A O   1 
ATOM   2153 C  CB  . THR A 1 310 ? 112.133 104.040 87.769  1.00 86.47  ? 310 THR A CB  1 
ATOM   2154 O  OG1 . THR A 1 310 ? 112.809 104.386 86.555  1.00 86.47  ? 310 THR A OG1 1 
ATOM   2155 C  CG2 . THR A 1 310 ? 111.482 105.277 88.345  1.00 86.47  ? 310 THR A CG2 1 
ATOM   2156 N  N   . SER A 1 311 ? 114.353 105.067 90.145  1.00 86.68  ? 311 SER A N   1 
ATOM   2157 C  CA  . SER A 1 311 ? 115.483 105.904 90.527  1.00 86.68  ? 311 SER A CA  1 
ATOM   2158 C  C   . SER A 1 311 ? 116.495 105.162 91.387  1.00 86.68  ? 311 SER A C   1 
ATOM   2159 O  O   . SER A 1 311 ? 117.698 105.407 91.267  1.00 86.68  ? 311 SER A O   1 
ATOM   2160 C  CB  . SER A 1 311 ? 114.992 107.145 91.275  1.00 86.68  ? 311 SER A CB  1 
ATOM   2161 O  OG  . SER A 1 311 ? 114.698 106.837 92.625  1.00 86.68  ? 311 SER A OG  1 
ATOM   2162 N  N   . LEU A 1 312 ? 116.031 104.259 92.253  1.00 87.11  ? 312 LEU A N   1 
ATOM   2163 C  CA  . LEU A 1 312 ? 116.950 103.442 93.039  1.00 87.11  ? 312 LEU A CA  1 
ATOM   2164 C  C   . LEU A 1 312 ? 117.790 102.544 92.142  1.00 87.11  ? 312 LEU A C   1 
ATOM   2165 O  O   . LEU A 1 312 ? 118.982 102.339 92.396  1.00 87.11  ? 312 LEU A O   1 
ATOM   2166 C  CB  . LEU A 1 312 ? 116.176 102.602 94.057  1.00 87.11  ? 312 LEU A CB  1 
ATOM   2167 C  CG  . LEU A 1 312 ? 116.026 103.176 95.466  1.00 87.11  ? 312 LEU A CG  1 
ATOM   2168 C  CD1 . LEU A 1 312 ? 115.428 102.138 96.395  1.00 87.11  ? 312 LEU A CD1 1 
ATOM   2169 C  CD2 . LEU A 1 312 ? 117.360 103.663 95.997  1.00 87.11  ? 312 LEU A CD2 1 
ATOM   2170 N  N   . GLY A 1 313 ? 117.189 101.999 91.091  1.00 87.36  ? 313 GLY A N   1 
ATOM   2171 C  CA  . GLY A 1 313 ? 117.944 101.173 90.175  1.00 87.36  ? 313 GLY A CA  1 
ATOM   2172 C  C   . GLY A 1 313 ? 118.792 101.926 89.180  1.00 87.36  ? 313 GLY A C   1 
ATOM   2173 O  O   . GLY A 1 313 ? 119.487 101.301 88.376  1.00 87.36  ? 313 GLY A O   1 
ATOM   2174 N  N   . SER A 1 314 ? 118.759 103.259 89.211  1.00 92.59  ? 314 SER A N   1 
ATOM   2175 C  CA  . SER A 1 314 ? 119.480 104.053 88.221  1.00 92.59  ? 314 SER A CA  1 
ATOM   2176 C  C   . SER A 1 314 ? 120.980 104.096 88.494  1.00 92.59  ? 314 SER A C   1 
ATOM   2177 O  O   . SER A 1 314 ? 121.782 104.123 87.554  1.00 92.59  ? 314 SER A O   1 
ATOM   2178 C  CB  . SER A 1 314 ? 118.912 105.469 88.175  1.00 92.59  ? 314 SER A CB  1 
ATOM   2179 O  OG  . SER A 1 314 ? 119.516 106.221 87.140  1.00 92.59  ? 314 SER A OG  1 
ATOM   2180 N  N   . TYR A 1 315 ? 121.381 104.102 89.767  1.00 94.73  ? 315 TYR A N   1 
ATOM   2181 C  CA  . TYR A 1 315 ? 122.791 104.251 90.108  1.00 94.73  ? 315 TYR A CA  1 
ATOM   2182 C  C   . TYR A 1 315 ? 123.592 102.967 89.940  1.00 94.73  ? 315 TYR A C   1 
ATOM   2183 O  O   . TYR A 1 315 ? 124.813 102.999 90.125  1.00 94.73  ? 315 TYR A O   1 
ATOM   2184 C  CB  . TYR A 1 315 ? 122.941 104.751 91.546  1.00 94.73  ? 315 TYR A CB  1 
ATOM   2185 C  CG  . TYR A 1 315 ? 122.069 105.931 91.901  1.00 94.73  ? 315 TYR A CG  1 
ATOM   2186 C  CD1 . TYR A 1 315 ? 122.139 107.113 91.179  1.00 94.73  ? 315 TYR A CD1 1 
ATOM   2187 C  CD2 . TYR A 1 315 ? 121.186 105.868 92.969  1.00 94.73  ? 315 TYR A CD2 1 
ATOM   2188 C  CE1 . TYR A 1 315 ? 121.349 108.195 91.504  1.00 94.73  ? 315 TYR A CE1 1 
ATOM   2189 C  CE2 . TYR A 1 315 ? 120.392 106.944 93.301  1.00 94.73  ? 315 TYR A CE2 1 
ATOM   2190 C  CZ  . TYR A 1 315 ? 120.477 108.105 92.565  1.00 94.73  ? 315 TYR A CZ  1 
ATOM   2191 O  OH  . TYR A 1 315 ? 119.687 109.181 92.893  1.00 94.73  ? 315 TYR A OH  1 
ATOM   2192 N  N   . ASN A 1 316 ? 122.952 101.849 89.606  1.00 94.48  ? 316 ASN A N   1 
ATOM   2193 C  CA  . ASN A 1 316 ? 123.665 100.587 89.485  1.00 94.48  ? 316 ASN A CA  1 
ATOM   2194 C  C   . ASN A 1 316 ? 124.640 100.620 88.311  1.00 94.48  ? 316 ASN A C   1 
ATOM   2195 O  O   . ASN A 1 316 ? 124.528 101.428 87.386  1.00 94.48  ? 316 ASN A O   1 
ATOM   2196 C  CB  . ASN A 1 316 ? 122.687 99.429  89.304  1.00 94.48  ? 316 ASN A CB  1 
ATOM   2197 C  CG  . ASN A 1 316 ? 121.990 99.054  90.584  1.00 94.48  ? 316 ASN A CG  1 
ATOM   2198 O  OD1 . ASN A 1 316 ? 121.307 98.036  90.653  1.00 94.48  ? 316 ASN A OD1 1 
ATOM   2199 N  ND2 . ASN A 1 316 ? 122.159 99.875  91.613  1.00 94.48  ? 316 ASN A ND2 1 
ATOM   2200 N  N   . LYS A 1 317 ? 125.618 99.722  88.369  1.00 94.31  ? 317 LYS A N   1 
ATOM   2201 C  CA  . LYS A 1 317 ? 126.526 99.512  87.255  1.00 94.31  ? 317 LYS A CA  1 
ATOM   2202 C  C   . LYS A 1 317 ? 125.797 98.817  86.111  1.00 94.31  ? 317 LYS A C   1 
ATOM   2203 O  O   . LYS A 1 317 ? 124.888 98.010  86.325  1.00 94.31  ? 317 LYS A O   1 
ATOM   2204 C  CB  . LYS A 1 317 ? 127.734 98.687  87.700  1.00 94.31  ? 317 LYS A CB  1 
ATOM   2205 C  CG  . LYS A 1 317 ? 128.748 98.411  86.604  1.00 94.31  ? 317 LYS A CG  1 
ATOM   2206 C  CD  . LYS A 1 317 ? 129.449 99.679  86.156  1.00 94.31  ? 317 LYS A CD  1 
ATOM   2207 C  CE  . LYS A 1 317 ? 130.565 99.366  85.174  1.00 94.31  ? 317 LYS A CE  1 
ATOM   2208 N  NZ  . LYS A 1 317 ? 130.033 98.819  83.896  1.00 94.31  ? 317 LYS A NZ  1 
ATOM   2209 N  N   . TYR A 1 318 ? 126.204 99.148  84.884  1.00 94.48  ? 318 TYR A N   1 
ATOM   2210 C  CA  . TYR A 1 318 ? 125.544 98.608  83.699  1.00 94.48  ? 318 TYR A CA  1 
ATOM   2211 C  C   . TYR A 1 318 ? 125.617 97.086  83.665  1.00 94.48  ? 318 TYR A C   1 
ATOM   2212 O  O   . TYR A 1 318 ? 124.607 96.410  83.442  1.00 94.48  ? 318 TYR A O   1 
ATOM   2213 C  CB  . TYR A 1 318 ? 126.175 99.208  82.444  1.00 94.48  ? 318 TYR A CB  1 
ATOM   2214 C  CG  . TYR A 1 318 ? 125.365 99.028  81.184  1.00 94.48  ? 318 TYR A CG  1 
ATOM   2215 C  CD1 . TYR A 1 318 ? 124.503 100.022 80.744  1.00 94.48  ? 318 TYR A CD1 1 
ATOM   2216 C  CD2 . TYR A 1 318 ? 125.477 97.872  80.423  1.00 94.48  ? 318 TYR A CD2 1 
ATOM   2217 C  CE1 . TYR A 1 318 ? 123.764 99.864  79.589  1.00 94.48  ? 318 TYR A CE1 1 
ATOM   2218 C  CE2 . TYR A 1 318 ? 124.744 97.706  79.266  1.00 94.48  ? 318 TYR A CE2 1 
ATOM   2219 C  CZ  . TYR A 1 318 ? 123.889 98.705  78.854  1.00 94.48  ? 318 TYR A CZ  1 
ATOM   2220 O  OH  . TYR A 1 318 ? 123.156 98.544  77.701  1.00 94.48  ? 318 TYR A OH  1 
ATOM   2221 N  N   . LYS A 1 319 ? 126.805 96.528  83.893  1.00 92.94  ? 319 LYS A N   1 
ATOM   2222 C  CA  . LYS A 1 319 ? 127.007 95.081  83.834  1.00 92.94  ? 319 LYS A CA  1 
ATOM   2223 C  C   . LYS A 1 319 ? 126.897 94.477  85.237  1.00 92.94  ? 319 LYS A C   1 
ATOM   2224 O  O   . LYS A 1 319 ? 127.878 94.098  85.875  1.00 92.94  ? 319 LYS A O   1 
ATOM   2225 C  CB  . LYS A 1 319 ? 128.349 94.767  83.185  1.00 92.94  ? 319 LYS A CB  1 
ATOM   2226 C  CG  . LYS A 1 319 ? 128.631 93.287  82.988  1.00 92.94  ? 319 LYS A CG  1 
ATOM   2227 C  CD  . LYS A 1 319 ? 127.725 92.690  81.927  1.00 92.94  ? 319 LYS A CD  1 
ATOM   2228 C  CE  . LYS A 1 319 ? 128.079 91.238  81.653  1.00 92.94  ? 319 LYS A CE  1 
ATOM   2229 N  NZ  . LYS A 1 319 ? 127.158 90.617  80.663  1.00 92.94  ? 319 LYS A NZ  1 
ATOM   2230 N  N   . TYR A 1 320 ? 125.660 94.409  85.720  1.00 91.50  ? 320 TYR A N   1 
ATOM   2231 C  CA  . TYR A 1 320 ? 125.357 93.925  87.059  1.00 91.50  ? 320 TYR A CA  1 
ATOM   2232 C  C   . TYR A 1 320 ? 124.129 93.028  87.004  1.00 91.50  ? 320 TYR A C   1 
ATOM   2233 O  O   . TYR A 1 320 ? 123.173 93.321  86.279  1.00 91.50  ? 320 TYR A O   1 
ATOM   2234 C  CB  . TYR A 1 320 ? 125.141 95.102  88.016  1.00 91.50  ? 320 TYR A CB  1 
ATOM   2235 C  CG  . TYR A 1 320 ? 124.625 94.725  89.383  1.00 91.50  ? 320 TYR A CG  1 
ATOM   2236 C  CD1 . TYR A 1 320 ? 125.435 94.067  90.294  1.00 91.50  ? 320 TYR A CD1 1 
ATOM   2237 C  CD2 . TYR A 1 320 ? 123.339 95.062  89.776  1.00 91.50  ? 320 TYR A CD2 1 
ATOM   2238 C  CE1 . TYR A 1 320 ? 124.970 93.731  91.547  1.00 91.50  ? 320 TYR A CE1 1 
ATOM   2239 C  CE2 . TYR A 1 320 ? 122.866 94.731  91.027  1.00 91.50  ? 320 TYR A CE2 1 
ATOM   2240 C  CZ  . TYR A 1 320 ? 123.685 94.068  91.909  1.00 91.50  ? 320 TYR A CZ  1 
ATOM   2241 O  OH  . TYR A 1 320 ? 123.217 93.737  93.158  1.00 91.50  ? 320 TYR A OH  1 
ATOM   2242 N  N   . ASN A 1 321 ? 124.161 91.938  87.766  1.00 90.17  ? 321 ASN A N   1 
ATOM   2243 C  CA  . ASN A 1 321 ? 123.081 90.952  87.787  1.00 90.17  ? 321 ASN A CA  1 
ATOM   2244 C  C   . ASN A 1 321 ? 122.043 91.374  88.817  1.00 90.17  ? 321 ASN A C   1 
ATOM   2245 O  O   . ASN A 1 321 ? 122.244 91.211  90.022  1.00 90.17  ? 321 ASN A O   1 
ATOM   2246 C  CB  . ASN A 1 321 ? 123.636 89.569  88.101  1.00 90.17  ? 321 ASN A CB  1 
ATOM   2247 C  CG  . ASN A 1 321 ? 122.878 88.465  87.402  1.00 90.17  ? 321 ASN A CG  1 
ATOM   2248 O  OD1 . ASN A 1 321 ? 121.663 88.349  87.541  1.00 90.17  ? 321 ASN A OD1 1 
ATOM   2249 N  ND2 . ASN A 1 321 ? 123.594 87.642  86.646  1.00 90.17  ? 321 ASN A ND2 1 
ATOM   2250 N  N   . SER A 1 322 ? 120.917 91.912  88.345  1.00 88.32  ? 322 SER A N   1 
ATOM   2251 C  CA  . SER A 1 322 ? 119.868 92.393  89.235  1.00 88.32  ? 322 SER A CA  1 
ATOM   2252 C  C   . SER A 1 322 ? 118.675 91.450  89.334  1.00 88.32  ? 322 SER A C   1 
ATOM   2253 O  O   . SER A 1 322 ? 117.819 91.653  90.201  1.00 88.32  ? 322 SER A O   1 
ATOM   2254 C  CB  . SER A 1 322 ? 119.385 93.773  88.779  1.00 88.32  ? 322 SER A CB  1 
ATOM   2255 O  OG  . SER A 1 322 ? 118.766 93.702  87.509  1.00 88.32  ? 322 SER A OG  1 
ATOM   2256 N  N   . TYR A 1 323 ? 118.599 90.432  88.475  1.00 86.31  ? 323 TYR A N   1 
ATOM   2257 C  CA  . TYR A 1 323 ? 117.470 89.506  88.507  1.00 86.31  ? 323 TYR A CA  1 
ATOM   2258 C  C   . TYR A 1 323 ? 117.418 88.750  89.828  1.00 86.31  ? 323 TYR A C   1 
ATOM   2259 O  O   . TYR A 1 323 ? 116.366 88.672  90.476  1.00 86.31  ? 323 TYR A O   1 
ATOM   2260 C  CB  . TYR A 1 323 ? 117.574 88.537  87.329  1.00 86.31  ? 323 TYR A CB  1 
ATOM   2261 C  CG  . TYR A 1 323 ? 116.395 87.609  87.143  1.00 86.31  ? 323 TYR A CG  1 
ATOM   2262 C  CD1 . TYR A 1 323 ? 115.298 87.993  86.387  1.00 86.31  ? 323 TYR A CD1 1 
ATOM   2263 C  CD2 . TYR A 1 323 ? 116.386 86.343  87.710  1.00 86.31  ? 323 TYR A CD2 1 
ATOM   2264 C  CE1 . TYR A 1 323 ? 114.223 87.148  86.208  1.00 86.31  ? 323 TYR A CE1 1 
ATOM   2265 C  CE2 . TYR A 1 323 ? 115.314 85.492  87.538  1.00 86.31  ? 323 TYR A CE2 1 
ATOM   2266 C  CZ  . TYR A 1 323 ? 114.236 85.899  86.786  1.00 86.31  ? 323 TYR A CZ  1 
ATOM   2267 O  OH  . TYR A 1 323 ? 113.166 85.053  86.612  1.00 86.31  ? 323 TYR A OH  1 
ATOM   2268 N  N   . ARG A 1 324 ? 118.547 88.167  90.213  1.00 88.79  ? 324 ARG A N   1 
ATOM   2269 C  CA  . ARG A 1 324 ? 118.604 87.402  91.452  1.00 88.79  ? 324 ARG A CA  1 
ATOM   2270 C  C   . ARG A 1 324 ? 118.191 88.269  92.621  1.00 88.79  ? 324 ARG A C   1 
ATOM   2271 O  O   . ARG A 1 324 ? 117.385 87.859  93.450  1.00 88.79  ? 324 ARG A O   1 
ATOM   2272 C  CB  . ARG A 1 324 ? 120.022 86.886  91.671  1.00 88.79  ? 324 ARG A CB  1 
ATOM   2273 C  CG  . ARG A 1 324 ? 120.605 86.165  90.467  1.00 88.79  ? 324 ARG A CG  1 
ATOM   2274 C  CD  . ARG A 1 324 ? 122.104 85.935  90.602  1.00 88.79  ? 324 ARG A CD  1 
ATOM   2275 N  NE  . ARG A 1 324 ? 122.452 85.110  91.757  1.00 88.79  ? 324 ARG A NE  1 
ATOM   2276 C  CZ  . ARG A 1 324 ? 122.997 85.575  92.878  1.00 88.79  ? 324 ARG A CZ  1 
ATOM   2277 N  NH1 . ARG A 1 324 ? 123.272 86.867  93.001  1.00 88.79  ? 324 ARG A NH1 1 
ATOM   2278 N  NH2 . ARG A 1 324 ? 123.275 84.746  93.874  1.00 88.79  ? 324 ARG A NH2 1 
ATOM   2279 N  N   . ASP A 1 325 ? 118.746 89.473  92.691  1.00 87.99  ? 325 ASP A N   1 
ATOM   2280 C  CA  . ASP A 1 325 ? 118.429 90.372  93.792  1.00 87.99  ? 325 ASP A CA  1 
ATOM   2281 C  C   . ASP A 1 325 ? 116.963 90.771  93.806  1.00 87.99  ? 325 ASP A C   1 
ATOM   2282 O  O   . ASP A 1 325 ? 116.339 90.787  94.859  1.00 87.99  ? 325 ASP A O   1 
ATOM   2283 C  CB  . ASP A 1 325 ? 119.311 91.614  93.719  1.00 87.99  ? 325 ASP A CB  1 
ATOM   2284 C  CG  . ASP A 1 325 ? 120.781 91.276  93.765  1.00 87.99  ? 325 ASP A CG  1 
ATOM   2285 O  OD1 . ASP A 1 325 ? 121.208 90.604  94.727  1.00 87.99  ? 325 ASP A OD1 1 
ATOM   2286 O  OD2 . ASP A 1 325 ? 121.509 91.679  92.839  1.00 87.99  ? 325 ASP A OD2 1 
ATOM   2287 N  N   . CYS A 1 326 ? 116.406 91.069  92.638  1.00 86.72  ? 326 CYS A N   1 
ATOM   2288 C  CA  . CYS A 1 326 ? 115.000 91.439  92.564  1.00 86.72  ? 326 CYS A CA  1 
ATOM   2289 C  C   . CYS A 1 326 ? 114.138 90.300  93.073  1.00 86.72  ? 326 CYS A C   1 
ATOM   2290 O  O   . CYS A 1 326 ? 113.120 90.526  93.728  1.00 86.72  ? 326 CYS A O   1 
ATOM   2291 C  CB  . CYS A 1 326 ? 114.595 91.800  91.137  1.00 86.72  ? 326 CYS A CB  1 
ATOM   2292 S  SG  . CYS A 1 326 ? 115.105 93.452  90.621  1.00 86.72  ? 326 CYS A SG  1 
ATOM   2293 N  N   . MET A 1 327 ? 114.548 89.072  92.773  1.00 87.44  ? 327 MET A N   1 
ATOM   2294 C  CA  . MET A 1 327 ? 113.778 87.916  93.222  1.00 87.44  ? 327 MET A CA  1 
ATOM   2295 C  C   . MET A 1 327 ? 113.907 87.717  94.727  1.00 87.44  ? 327 MET A C   1 
ATOM   2296 O  O   . MET A 1 327 ? 112.903 87.505  95.422  1.00 87.44  ? 327 MET A O   1 
ATOM   2297 C  CB  . MET A 1 327 ? 114.225 86.662  92.473  1.00 87.44  ? 327 MET A CB  1 
ATOM   2298 C  CG  . MET A 1 327 ? 113.941 86.681  90.977  1.00 87.44  ? 327 MET A CG  1 
ATOM   2299 S  SD  . MET A 1 327 ? 112.189 86.798  90.570  1.00 87.44  ? 327 MET A SD  1 
ATOM   2300 C  CE  . MET A 1 327 ? 112.045 88.528  90.127  1.00 87.44  ? 327 MET A CE  1 
ATOM   2301 N  N   . LEU A 1 328 ? 115.131 87.803  95.253  1.00 85.71  ? 328 LEU A N   1 
ATOM   2302 C  CA  . LEU A 1 328 ? 115.335 87.599  96.685  1.00 85.71  ? 328 LEU A CA  1 
ATOM   2303 C  C   . LEU A 1 328 ? 114.653 88.690  97.505  1.00 85.71  ? 328 LEU A C   1 
ATOM   2304 O  O   . LEU A 1 328 ? 114.058 88.412  98.554  1.00 85.71  ? 328 LEU A O   1 
ATOM   2305 C  CB  . LEU A 1 328 ? 116.829 87.535  96.998  1.00 85.71  ? 328 LEU A CB  1 
ATOM   2306 C  CG  . LEU A 1 328 ? 117.544 86.259  96.546  1.00 85.71  ? 328 LEU A CG  1 
ATOM   2307 C  CD1 . LEU A 1 328 ? 119.041 86.486  96.436  1.00 85.71  ? 328 LEU A CD1 1 
ATOM   2308 C  CD2 . LEU A 1 328 ? 117.243 85.113  97.497  1.00 85.71  ? 328 LEU A CD2 1 
ATOM   2309 N  N   . LEU A 1 329 ? 114.727 89.941  97.044  1.00 82.60  ? 329 LEU A N   1 
ATOM   2310 C  CA  . LEU A 1 329 ? 114.097 91.033  97.779  1.00 82.60  ? 329 LEU A CA  1 
ATOM   2311 C  C   . LEU A 1 329 ? 112.577 90.904  97.773  1.00 82.60  ? 329 LEU A C   1 
ATOM   2312 O  O   . LEU A 1 329 ? 111.922 91.156  98.793  1.00 82.60  ? 329 LEU A O   1 
ATOM   2313 C  CB  . LEU A 1 329 ? 114.539 92.373  97.193  1.00 82.60  ? 329 LEU A CB  1 
ATOM   2314 C  CG  . LEU A 1 329 ? 115.996 92.737  97.496  1.00 82.60  ? 329 LEU A CG  1 
ATOM   2315 C  CD1 . LEU A 1 329 ? 116.378 94.061  96.863  1.00 82.60  ? 329 LEU A CD1 1 
ATOM   2316 C  CD2 . LEU A 1 329 ? 116.246 92.764  98.995  1.00 82.60  ? 329 LEU A CD2 1 
ATOM   2317 N  N   . GLY A 1 330 ? 111.997 90.512  96.635  1.00 79.21  ? 330 GLY A N   1 
ATOM   2318 C  CA  . GLY A 1 330 ? 110.563 90.272  96.598  1.00 79.21  ? 330 GLY A CA  1 
ATOM   2319 C  C   . GLY A 1 330 ? 110.143 89.145  97.521  1.00 79.21  ? 330 GLY A C   1 
ATOM   2320 O  O   . GLY A 1 330 ? 109.111 89.232  98.198  1.00 79.21  ? 330 GLY A O   1 
ATOM   2321 N  N   . CYS A 1 331 ? 110.937 88.072  97.563  1.00 81.73  ? 331 CYS A N   1 
ATOM   2322 C  CA  . CYS A 1 331 ? 110.654 86.985  98.494  1.00 81.73  ? 331 CYS A CA  1 
ATOM   2323 C  C   . CYS A 1 331 ? 110.691 87.479  99.934  1.00 81.73  ? 331 CYS A C   1 
ATOM   2324 O  O   . CYS A 1 331 ? 109.815 87.144  100.740 1.00 81.73  ? 331 CYS A O   1 
ATOM   2325 C  CB  . CYS A 1 331 ? 111.650 85.843  98.291  1.00 81.73  ? 331 CYS A CB  1 
ATOM   2326 S  SG  . CYS A 1 331 ? 111.531 85.011  96.692  1.00 81.73  ? 331 CYS A SG  1 
ATOM   2327 N  N   . LEU A 1 332 ? 111.696 88.291  100.271 1.00 78.75  ? 332 LEU A N   1 
ATOM   2328 C  CA  . LEU A 1 332 ? 111.802 88.821  101.627 1.00 78.75  ? 332 LEU A CA  1 
ATOM   2329 C  C   . LEU A 1 332 ? 110.585 89.667  101.983 1.00 78.75  ? 332 LEU A C   1 
ATOM   2330 O  O   . LEU A 1 332 ? 110.008 89.522  103.068 1.00 78.75  ? 332 LEU A O   1 
ATOM   2331 C  CB  . LEU A 1 332 ? 113.087 89.639  101.769 1.00 78.75  ? 332 LEU A CB  1 
ATOM   2332 C  CG  . LEU A 1 332 ? 113.273 90.443  103.058 1.00 78.75  ? 332 LEU A CG  1 
ATOM   2333 C  CD1 . LEU A 1 332 ? 113.501 89.525  104.246 1.00 78.75  ? 332 LEU A CD1 1 
ATOM   2334 C  CD2 . LEU A 1 332 ? 114.419 91.431  102.916 1.00 78.75  ? 332 LEU A CD2 1 
ATOM   2335 N  N   . ASN A 1 333 ? 110.164 90.540  101.065 1.00 72.39  ? 333 ASN A N   1 
ATOM   2336 C  CA  . ASN A 1 333 ? 109.023 91.414  101.330 1.00 72.39  ? 333 ASN A CA  1 
ATOM   2337 C  C   . ASN A 1 333 ? 107.743 90.613  101.547 1.00 72.39  ? 333 ASN A C   1 
ATOM   2338 O  O   . ASN A 1 333 ? 107.021 90.818  102.536 1.00 72.39  ? 333 ASN A O   1 
ATOM   2339 C  CB  . ASN A 1 333 ? 108.851 92.395  100.173 1.00 72.39  ? 333 ASN A CB  1 
ATOM   2340 C  CG  . ASN A 1 333 ? 107.882 93.510  100.492 1.00 72.39  ? 333 ASN A CG  1 
ATOM   2341 O  OD1 . ASN A 1 333 ? 107.381 93.615  101.611 1.00 72.39  ? 333 ASN A OD1 1 
ATOM   2342 N  ND2 . ASN A 1 333 ? 107.609 94.351  99.505  1.00 72.39  ? 333 ASN A ND2 1 
ATOM   2343 N  N   . SER A 1 334 ? 107.439 89.697  100.623 1.00 75.49  ? 334 SER A N   1 
ATOM   2344 C  CA  . SER A 1 334 ? 106.201 88.933  100.738 1.00 75.49  ? 334 SER A CA  1 
ATOM   2345 C  C   . SER A 1 334 ? 106.210 88.042  101.972 1.00 75.49  ? 334 SER A C   1 
ATOM   2346 O  O   . SER A 1 334 ? 105.187 87.917  102.659 1.00 75.49  ? 334 SER A O   1 
ATOM   2347 C  CB  . SER A 1 334 ? 105.972 88.109  99.474  1.00 75.49  ? 334 SER A CB  1 
ATOM   2348 O  OG  . SER A 1 334 ? 105.629 88.947  98.385  1.00 75.49  ? 334 SER A OG  1 
ATOM   2349 N  N   . GLY A 1 335 ? 107.350 87.415  102.275 1.00 72.77  ? 335 GLY A N   1 
ATOM   2350 C  CA  . GLY A 1 335 ? 107.434 86.609  103.479 1.00 72.77  ? 335 GLY A CA  1 
ATOM   2351 C  C   . GLY A 1 335 ? 107.242 87.427  104.739 1.00 72.77  ? 335 GLY A C   1 
ATOM   2352 O  O   . GLY A 1 335 ? 106.580 86.984  105.680 1.00 72.77  ? 335 GLY A O   1 
ATOM   2353 N  N   . THR A 1 336 ? 107.814 88.634  104.775 1.00 72.63  ? 336 THR A N   1 
ATOM   2354 C  CA  . THR A 1 336 ? 107.623 89.506  105.928 1.00 72.63  ? 336 THR A CA  1 
ATOM   2355 C  C   . THR A 1 336 ? 106.152 89.846  106.114 1.00 72.63  ? 336 THR A C   1 
ATOM   2356 O  O   . THR A 1 336 ? 105.628 89.791  107.232 1.00 72.63  ? 336 THR A O   1 
ATOM   2357 C  CB  . THR A 1 336 ? 108.450 90.782  105.767 1.00 72.63  ? 336 THR A CB  1 
ATOM   2358 O  OG1 . THR A 1 336 ? 109.786 90.443  105.378 1.00 72.63  ? 336 THR A OG1 1 
ATOM   2359 C  CG2 . THR A 1 336 ? 108.488 91.554  107.073 1.00 72.63  ? 336 THR A CG2 1 
ATOM   2360 N  N   . SER A 1 337 ? 105.464 90.190  105.020 1.00 71.29  ? 337 SER A N   1 
ATOM   2361 C  CA  . SER A 1 337 ? 104.042 90.517  105.122 1.00 71.29  ? 337 SER A CA  1 
ATOM   2362 C  C   . SER A 1 337 ? 103.234 89.323  105.617 1.00 71.29  ? 337 SER A C   1 
ATOM   2363 O  O   . SER A 1 337 ? 102.367 89.462  106.485 1.00 71.29  ? 337 SER A O   1 
ATOM   2364 C  CB  . SER A 1 337 ? 103.508 90.998  103.775 1.00 71.29  ? 337 SER A CB  1 
ATOM   2365 O  OG  . SER A 1 337 ? 104.069 92.246  103.417 1.00 71.29  ? 337 SER A OG  1 
ATOM   2366 N  N   . PHE A 1 338 ? 103.518 88.135  105.083 1.00 75.77  ? 338 PHE A N   1 
ATOM   2367 C  CA  . PHE A 1 338 ? 102.759 86.939  105.442 1.00 75.77  ? 338 PHE A CA  1 
ATOM   2368 C  C   . PHE A 1 338 ? 102.975 86.565  106.912 1.00 75.77  ? 338 PHE A C   1 
ATOM   2369 O  O   . PHE A 1 338 ? 102.020 86.268  107.651 1.00 75.77  ? 338 PHE A O   1 
ATOM   2370 C  CB  . PHE A 1 338 ? 103.174 85.819  104.481 1.00 75.77  ? 338 PHE A CB  1 
ATOM   2371 C  CG  . PHE A 1 338 ? 102.433 84.528  104.649 1.00 75.77  ? 338 PHE A CG  1 
ATOM   2372 C  CD1 . PHE A 1 338 ? 101.124 84.408  104.216 1.00 75.77  ? 338 PHE A CD1 1 
ATOM   2373 C  CD2 . PHE A 1 338 ? 103.075 83.407  105.142 1.00 75.77  ? 338 PHE A CD2 1 
ATOM   2374 C  CE1 . PHE A 1 338 ? 100.448 83.213  104.338 1.00 75.77  ? 338 PHE A CE1 1 
ATOM   2375 C  CE2 . PHE A 1 338 ? 102.408 82.207  105.257 1.00 75.77  ? 338 PHE A CE2 1 
ATOM   2376 C  CZ  . PHE A 1 338 ? 101.090 82.110  104.857 1.00 75.77  ? 338 PHE A CZ  1 
ATOM   2377 N  N   . VAL A 1 339 ? 104.230 86.619  107.366 1.00 75.01  ? 339 VAL A N   1 
ATOM   2378 C  CA  . VAL A 1 339 ? 104.552 86.315  108.759 1.00 75.01  ? 339 VAL A CA  1 
ATOM   2379 C  C   . VAL A 1 339 ? 103.943 87.350  109.705 1.00 75.01  ? 339 VAL A C   1 
ATOM   2380 O  O   . VAL A 1 339 ? 103.404 87.002  110.766 1.00 75.01  ? 339 VAL A O   1 
ATOM   2381 C  CB  . VAL A 1 339 ? 106.079 86.205  108.918 1.00 75.01  ? 339 VAL A CB  1 
ATOM   2382 C  CG1 . VAL A 1 339 ? 106.458 86.038  110.362 1.00 75.01  ? 339 VAL A CG1 1 
ATOM   2383 C  CG2 . VAL A 1 339 ? 106.600 85.023  108.117 1.00 75.01  ? 339 VAL A CG2 1 
ATOM   2384 N  N   . SER A 1 340 ? 104.016 88.635  109.345 1.00 73.27  ? 340 SER A N   1 
ATOM   2385 C  CA  . SER A 1 340 ? 103.401 89.665  110.176 1.00 73.27  ? 340 SER A CA  1 
ATOM   2386 C  C   . SER A 1 340 ? 101.886 89.505  110.222 1.00 73.27  ? 340 SER A C   1 
ATOM   2387 O  O   . SER A 1 340 ? 101.251 89.820  111.236 1.00 73.27  ? 340 SER A O   1 
ATOM   2388 C  CB  . SER A 1 340 ? 103.780 91.050  109.655 1.00 73.27  ? 340 SER A CB  1 
ATOM   2389 O  OG  . SER A 1 340 ? 105.186 91.211  109.626 1.00 73.27  ? 340 SER A OG  1 
ATOM   2390 N  N   . GLY A 1 341 ? 101.287 89.037  109.124 1.00 67.80  ? 341 GLY A N   1 
ATOM   2391 C  CA  . GLY A 1 341 ? 99.870  88.725  109.148 1.00 67.80  ? 341 GLY A CA  1 
ATOM   2392 C  C   . GLY A 1 341 ? 99.539  87.649  110.162 1.00 67.80  ? 341 GLY A C   1 
ATOM   2393 O  O   . GLY A 1 341 ? 98.583  87.784  110.931 1.00 67.80  ? 341 GLY A O   1 
ATOM   2394 N  N   . PHE A 1 342 ? 100.325 86.567  110.177 1.00 71.26  ? 342 PHE A N   1 
ATOM   2395 C  CA  . PHE A 1 342 ? 100.191 85.588  111.259 1.00 71.26  ? 342 PHE A CA  1 
ATOM   2396 C  C   . PHE A 1 342 ? 100.255 86.258  112.626 1.00 71.26  ? 342 PHE A C   1 
ATOM   2397 O  O   . PHE A 1 342 ? 99.397  86.029  113.494 1.00 71.26  ? 342 PHE A O   1 
ATOM   2398 C  CB  . PHE A 1 342 ? 101.277 84.514  111.167 1.00 71.26  ? 342 PHE A CB  1 
ATOM   2399 C  CG  . PHE A 1 342 ? 100.929 83.359  110.282 1.00 71.26  ? 342 PHE A CG  1 
ATOM   2400 C  CD1 . PHE A 1 342 ? 100.091 82.359  110.744 1.00 71.26  ? 342 PHE A CD1 1 
ATOM   2401 C  CD2 . PHE A 1 342 ? 101.453 83.249  109.012 1.00 71.26  ? 342 PHE A CD2 1 
ATOM   2402 C  CE1 . PHE A 1 342 ? 99.769  81.284  109.949 1.00 71.26  ? 342 PHE A CE1 1 
ATOM   2403 C  CE2 . PHE A 1 342 ? 101.132 82.175  108.217 1.00 71.26  ? 342 PHE A CE2 1 
ATOM   2404 C  CZ  . PHE A 1 342 ? 100.291 81.193  108.684 1.00 71.26  ? 342 PHE A CZ  1 
ATOM   2405 N  N   . ALA A 1 343 ? 101.273 87.098  112.825 1.00 68.86  ? 343 ALA A N   1 
ATOM   2406 C  CA  . ALA A 1 343 ? 101.519 87.677  114.143 1.00 68.86  ? 343 ALA A CA  1 
ATOM   2407 C  C   . ALA A 1 343 ? 100.341 88.523  114.611 1.00 68.86  ? 343 ALA A C   1 
ATOM   2408 O  O   . ALA A 1 343 ? 99.913  88.427  115.766 1.00 68.86  ? 343 ALA A O   1 
ATOM   2409 C  CB  . ALA A 1 343 ? 102.800 88.510  114.116 1.00 68.86  ? 343 ALA A CB  1 
ATOM   2410 N  N   . ILE A 1 344 ? 99.800  89.359  113.722 1.00 69.15  ? 344 ILE A N   1 
ATOM   2411 C  CA  . ILE A 1 344 ? 98.728  90.264  114.129 1.00 69.15  ? 344 ILE A CA  1 
ATOM   2412 C  C   . ILE A 1 344 ? 97.402  89.519  114.265 1.00 69.15  ? 344 ILE A C   1 
ATOM   2413 O  O   . ILE A 1 344 ? 96.608  89.802  115.174 1.00 69.15  ? 344 ILE A O   1 
ATOM   2414 C  CB  . ILE A 1 344 ? 98.629  91.459  113.162 1.00 69.15  ? 344 ILE A CB  1 
ATOM   2415 C  CG1 . ILE A 1 344 ? 97.668  92.509  113.725 1.00 69.15  ? 344 ILE A CG1 1 
ATOM   2416 C  CG2 . ILE A 1 344 ? 98.205  91.019  111.775 1.00 69.15  ? 344 ILE A CG2 1 
ATOM   2417 C  CD1 . ILE A 1 344 ? 97.899  93.902  113.199 1.00 69.15  ? 344 ILE A CD1 1 
ATOM   2418 N  N   . PHE A 1 345 ? 97.134  88.551  113.385 1.00 66.44  ? 345 PHE A N   1 
ATOM   2419 C  CA  . PHE A 1 345 ? 95.849  87.874  113.456 1.00 66.44  ? 345 PHE A CA  1 
ATOM   2420 C  C   . PHE A 1 345 ? 95.763  86.919  114.636 1.00 66.44  ? 345 PHE A C   1 
ATOM   2421 O  O   . PHE A 1 345 ? 94.657  86.665  115.125 1.00 66.44  ? 345 PHE A O   1 
ATOM   2422 C  CB  . PHE A 1 345 ? 95.564  87.149  112.145 1.00 66.44  ? 345 PHE A CB  1 
ATOM   2423 C  CG  . PHE A 1 345 ? 94.883  88.012  111.126 1.00 66.44  ? 345 PHE A CG  1 
ATOM   2424 C  CD1 . PHE A 1 345 ? 93.506  88.127  111.106 1.00 66.44  ? 345 PHE A CD1 1 
ATOM   2425 C  CD2 . PHE A 1 345 ? 95.622  88.731  110.206 1.00 66.44  ? 345 PHE A CD2 1 
ATOM   2426 C  CE1 . PHE A 1 345 ? 92.882  88.929  110.178 1.00 66.44  ? 345 PHE A CE1 1 
ATOM   2427 C  CE2 . PHE A 1 345 ? 95.002  89.534  109.276 1.00 66.44  ? 345 PHE A CE2 1 
ATOM   2428 C  CZ  . PHE A 1 345 ? 93.631  89.633  109.263 1.00 66.44  ? 345 PHE A CZ  1 
ATOM   2429 N  N   . SER A 1 346 ? 96.897  86.417  115.135 1.00 70.83  ? 346 SER A N   1 
ATOM   2430 C  CA  . SER A 1 346 ? 96.854  85.616  116.355 1.00 70.83  ? 346 SER A CA  1 
ATOM   2431 C  C   . SER A 1 346 ? 96.307  86.425  117.531 1.00 70.83  ? 346 SER A C   1 
ATOM   2432 O  O   . SER A 1 346 ? 95.380  85.989  118.227 1.00 70.83  ? 346 SER A O   1 
ATOM   2433 C  CB  . SER A 1 346 ? 98.246  85.075  116.671 1.00 70.83  ? 346 SER A CB  1 
ATOM   2434 O  OG  . SER A 1 346 ? 98.743  84.309  115.590 1.00 70.83  ? 346 SER A OG  1 
ATOM   2435 N  N   . ILE A 1 347 ? 96.860  87.620  117.761 1.00 71.11  ? 347 ILE A N   1 
ATOM   2436 C  CA  . ILE A 1 347 ? 96.381  88.441  118.869 1.00 71.11  ? 347 ILE A CA  1 
ATOM   2437 C  C   . ILE A 1 347 ? 94.989  88.989  118.583 1.00 71.11  ? 347 ILE A C   1 
ATOM   2438 O  O   . ILE A 1 347 ? 94.214  89.234  119.513 1.00 71.11  ? 347 ILE A O   1 
ATOM   2439 C  CB  . ILE A 1 347 ? 97.380  89.568  119.199 1.00 71.11  ? 347 ILE A CB  1 
ATOM   2440 C  CG1 . ILE A 1 347 ? 97.760  90.352  117.946 1.00 71.11  ? 347 ILE A CG1 1 
ATOM   2441 C  CG2 . ILE A 1 347 ? 98.619  89.006  119.871 1.00 71.11  ? 347 ILE A CG2 1 
ATOM   2442 C  CD1 . ILE A 1 347 ? 98.740  91.468  118.202 1.00 71.11  ? 347 ILE A CD1 1 
ATOM   2443 N  N   . LEU A 1 348 ? 94.641  89.194  117.309 1.00 70.85  ? 348 LEU A N   1 
ATOM   2444 C  CA  . LEU A 1 348 ? 93.276  89.601  116.983 1.00 70.85  ? 348 LEU A CA  1 
ATOM   2445 C  C   . LEU A 1 348 ? 92.269  88.531  117.396 1.00 70.85  ? 348 LEU A C   1 
ATOM   2446 O  O   . LEU A 1 348 ? 91.239  88.832  118.014 1.00 70.85  ? 348 LEU A O   1 
ATOM   2447 C  CB  . LEU A 1 348 ? 93.170  89.899  115.490 1.00 70.85  ? 348 LEU A CB  1 
ATOM   2448 C  CG  . LEU A 1 348 ? 92.120  90.913  115.051 1.00 70.85  ? 348 LEU A CG  1 
ATOM   2449 C  CD1 . LEU A 1 348 ? 92.292  92.204  115.815 1.00 70.85  ? 348 LEU A CD1 1 
ATOM   2450 C  CD2 . LEU A 1 348 ? 92.252  91.163  113.567 1.00 70.85  ? 348 LEU A CD2 1 
ATOM   2451 N  N   . GLY A 1 349 ? 92.556  87.269  117.069 1.00 73.03  ? 349 GLY A N   1 
ATOM   2452 C  CA  . GLY A 1 349 ? 91.701  86.186  117.524 1.00 73.03  ? 349 GLY A CA  1 
ATOM   2453 C  C   . GLY A 1 349 ? 91.678  86.060  119.035 1.00 73.03  ? 349 GLY A C   1 
ATOM   2454 O  O   . GLY A 1 349 ? 90.639  85.756  119.629 1.00 73.03  ? 349 GLY A O   1 
ATOM   2455 N  N   . PHE A 1 350 ? 92.824  86.298  119.679 1.00 76.65  ? 350 PHE A N   1 
ATOM   2456 C  CA  . PHE A 1 350 ? 92.867  86.273  121.139 1.00 76.65  ? 350 PHE A CA  1 
ATOM   2457 C  C   . PHE A 1 350 ? 91.940  87.326  121.737 1.00 76.65  ? 350 PHE A C   1 
ATOM   2458 O  O   . PHE A 1 350 ? 91.177  87.042  122.667 1.00 76.65  ? 350 PHE A O   1 
ATOM   2459 C  CB  . PHE A 1 350 ? 94.297  86.489  121.632 1.00 76.65  ? 350 PHE A CB  1 
ATOM   2460 C  CG  . PHE A 1 350 ? 94.376  87.013  123.038 1.00 76.65  ? 350 PHE A CG  1 
ATOM   2461 C  CD1 . PHE A 1 350 ? 94.079  86.194  124.113 1.00 76.65  ? 350 PHE A CD1 1 
ATOM   2462 C  CD2 . PHE A 1 350 ? 94.735  88.326  123.284 1.00 76.65  ? 350 PHE A CD2 1 
ATOM   2463 C  CE1 . PHE A 1 350 ? 94.144  86.672  125.402 1.00 76.65  ? 350 PHE A CE1 1 
ATOM   2464 C  CE2 . PHE A 1 350 ? 94.800  88.809  124.571 1.00 76.65  ? 350 PHE A CE2 1 
ATOM   2465 C  CZ  . PHE A 1 350 ? 94.506  87.981  125.632 1.00 76.65  ? 350 PHE A CZ  1 
ATOM   2466 N  N   . MET A 1 351 ? 92.000  88.555  121.218 1.00 79.34  ? 351 MET A N   1 
ATOM   2467 C  CA  . MET A 1 351 ? 91.138  89.621  121.720 1.00 79.34  ? 351 MET A CA  1 
ATOM   2468 C  C   . MET A 1 351 ? 89.671  89.309  121.469 1.00 79.34  ? 351 MET A C   1 
ATOM   2469 O  O   . MET A 1 351 ? 88.818  89.559  122.330 1.00 79.34  ? 351 MET A O   1 
ATOM   2470 C  CB  . MET A 1 351 ? 91.510  90.955  121.076 1.00 79.34  ? 351 MET A CB  1 
ATOM   2471 C  CG  . MET A 1 351 ? 92.830  91.529  121.543 1.00 79.34  ? 351 MET A CG  1 
ATOM   2472 S  SD  . MET A 1 351 ? 93.079  93.227  120.995 1.00 79.34  ? 351 MET A SD  1 
ATOM   2473 C  CE  . MET A 1 351 ? 92.244  93.204  119.415 1.00 79.34  ? 351 MET A CE  1 
ATOM   2474 N  N   . ALA A 1 352 ? 89.356  88.770  120.288 1.00 80.96  ? 352 ALA A N   1 
ATOM   2475 C  CA  . ALA A 1 352 ? 87.971  88.428  119.984 1.00 80.96  ? 352 ALA A CA  1 
ATOM   2476 C  C   . ALA A 1 352 ? 87.441  87.369  120.940 1.00 80.96  ? 352 ALA A C   1 
ATOM   2477 O  O   . ALA A 1 352 ? 86.287  87.441  121.376 1.00 80.96  ? 352 ALA A O   1 
ATOM   2478 C  CB  . ALA A 1 352 ? 87.850  87.960  118.538 1.00 80.96  ? 352 ALA A CB  1 
ATOM   2479 N  N   . GLN A 1 353 ? 88.262  86.372  121.275 1.00 86.10  ? 353 GLN A N   1 
ATOM   2480 C  CA  . GLN A 1 353 ? 87.838  85.408  122.285 1.00 86.10  ? 353 GLN A CA  1 
ATOM   2481 C  C   . GLN A 1 353 ? 87.726  86.046  123.665 1.00 86.10  ? 353 GLN A C   1 
ATOM   2482 O  O   . GLN A 1 353 ? 86.842  85.678  124.446 1.00 86.10  ? 353 GLN A O   1 
ATOM   2483 C  CB  . GLN A 1 353 ? 88.800  84.224  122.341 1.00 86.10  ? 353 GLN A CB  1 
ATOM   2484 C  CG  . GLN A 1 353 ? 88.356  83.144  123.318 1.00 86.10  ? 353 GLN A CG  1 
ATOM   2485 C  CD  . GLN A 1 353 ? 89.278  81.948  123.332 1.00 86.10  ? 353 GLN A CD  1 
ATOM   2486 O  OE1 . GLN A 1 353 ? 90.287  81.922  122.637 1.00 86.10  ? 353 GLN A OE1 1 
ATOM   2487 N  NE2 . GLN A 1 353 ? 88.932  80.944  124.129 1.00 86.10  ? 353 GLN A NE2 1 
ATOM   2488 N  N   . GLU A 1 354 ? 88.614  86.990  123.985 1.00 89.12  ? 354 GLU A N   1 
ATOM   2489 C  CA  . GLU A 1 354 ? 88.618  87.586  125.318 1.00 89.12  ? 354 GLU A CA  1 
ATOM   2490 C  C   . GLU A 1 354 ? 87.382  88.444  125.555 1.00 89.12  ? 354 GLU A C   1 
ATOM   2491 O  O   . GLU A 1 354 ? 86.831  88.454  126.661 1.00 89.12  ? 354 GLU A O   1 
ATOM   2492 C  CB  . GLU A 1 354 ? 89.889  88.410  125.519 1.00 89.12  ? 354 GLU A CB  1 
ATOM   2493 C  CG  . GLU A 1 354 ? 90.178  88.754  126.968 1.00 89.12  ? 354 GLU A CG  1 
ATOM   2494 C  CD  . GLU A 1 354 ? 91.270  89.792  127.112 1.00 89.12  ? 354 GLU A CD  1 
ATOM   2495 O  OE1 . GLU A 1 354 ? 91.336  90.709  126.267 1.00 89.12  ? 354 GLU A OE1 1 
ATOM   2496 O  OE2 . GLU A 1 354 ? 92.065  89.689  128.070 1.00 89.12  ? 354 GLU A OE2 1 
ATOM   2497 N  N   . GLN A 1 355 ? 86.938  89.179  124.537 1.00 91.97  ? 355 GLN A N   1 
ATOM   2498 C  CA  . GLN A 1 355 ? 85.756  90.021  124.667 1.00 91.97  ? 355 GLN A CA  1 
ATOM   2499 C  C   . GLN A 1 355 ? 84.453  89.267  124.439 1.00 91.97  ? 355 GLN A C   1 
ATOM   2500 O  O   . GLN A 1 355 ? 83.381  89.831  124.679 1.00 91.97  ? 355 GLN A O   1 
ATOM   2501 C  CB  . GLN A 1 355 ? 85.835  91.202  123.697 1.00 91.97  ? 355 GLN A CB  1 
ATOM   2502 C  CG  . GLN A 1 355 ? 86.881  92.232  124.067 1.00 91.97  ? 355 GLN A CG  1 
ATOM   2503 C  CD  . GLN A 1 355 ? 87.090  93.258  122.980 1.00 91.97  ? 355 GLN A CD  1 
ATOM   2504 O  OE1 . GLN A 1 355 ? 86.175  93.565  122.219 1.00 91.97  ? 355 GLN A OE1 1 
ATOM   2505 N  NE2 . GLN A 1 355 ? 88.301  93.793  122.895 1.00 91.97  ? 355 GLN A NE2 1 
ATOM   2506 N  N   . GLY A 1 356 ? 84.516  88.019  123.987 1.00 95.05  ? 356 GLY A N   1 
ATOM   2507 C  CA  . GLY A 1 356 ? 83.319  87.219  123.792 1.00 95.05  ? 356 GLY A CA  1 
ATOM   2508 C  C   . GLY A 1 356 ? 82.394  87.701  122.696 1.00 95.05  ? 356 GLY A C   1 
ATOM   2509 O  O   . GLY A 1 356 ? 81.169  87.619  122.846 1.00 95.05  ? 356 GLY A O   1 
ATOM   2510 N  N   . VAL A 1 357 ? 82.948  88.201  121.591 1.00 89.56  ? 357 VAL A N   1 
ATOM   2511 C  CA  . VAL A 1 357 ? 82.161  88.658  120.454 1.00 89.56  ? 357 VAL A CA  1 
ATOM   2512 C  C   . VAL A 1 357 ? 82.767  88.091  119.176 1.00 89.56  ? 357 VAL A C   1 
ATOM   2513 O  O   . VAL A 1 357 ? 83.732  87.328  119.200 1.00 89.56  ? 357 VAL A O   1 
ATOM   2514 C  CB  . VAL A 1 357 ? 82.071  90.195  120.377 1.00 89.56  ? 357 VAL A CB  1 
ATOM   2515 C  CG1 . VAL A 1 357 ? 81.265  90.741  121.542 1.00 89.56  ? 357 VAL A CG1 1 
ATOM   2516 C  CG2 . VAL A 1 357 ? 83.450  90.802  120.363 1.00 89.56  ? 357 VAL A CG2 1 
ATOM   2517 N  N   . ASP A 1 358 ? 82.175  88.478  118.050 1.00 86.24  ? 358 ASP A N   1 
ATOM   2518 C  CA  . ASP A 1 358 ? 82.594  87.957  116.757 1.00 86.24  ? 358 ASP A CA  1 
ATOM   2519 C  C   . ASP A 1 358 ? 83.983  88.467  116.394 1.00 86.24  ? 358 ASP A C   1 
ATOM   2520 O  O   . ASP A 1 358 ? 84.418  89.520  116.865 1.00 86.24  ? 358 ASP A O   1 
ATOM   2521 C  CB  . ASP A 1 358 ? 81.585  88.357  115.680 1.00 86.24  ? 358 ASP A CB  1 
ATOM   2522 C  CG  . ASP A 1 358 ? 81.824  87.651  114.360 1.00 86.24  ? 358 ASP A CG  1 
ATOM   2523 O  OD1 . ASP A 1 358 ? 82.757  88.047  113.629 1.00 86.24  ? 358 ASP A OD1 1 
ATOM   2524 O  OD2 . ASP A 1 358 ? 81.077  86.699  114.052 1.00 86.24  ? 358 ASP A OD2 1 
ATOM   2525 N  N   . ILE A 1 359 ? 84.682  87.702  115.550 1.00 79.53  ? 359 ILE A N   1 
ATOM   2526 C  CA  . ILE A 1 359 ? 86.014  88.099  115.099 1.00 79.53  ? 359 ILE A CA  1 
ATOM   2527 C  C   . ILE A 1 359 ? 85.949  89.435  114.373 1.00 79.53  ? 359 ILE A C   1 
ATOM   2528 O  O   . ILE A 1 359 ? 86.833  90.287  114.523 1.00 79.53  ? 359 ILE A O   1 
ATOM   2529 C  CB  . ILE A 1 359 ? 86.625  87.008  114.201 1.00 79.53  ? 359 ILE A CB  1 
ATOM   2530 C  CG1 . ILE A 1 359 ? 86.582  85.639  114.882 1.00 79.53  ? 359 ILE A CG1 1 
ATOM   2531 C  CG2 . ILE A 1 359 ? 88.062  87.359  113.845 1.00 79.53  ? 359 ILE A CG2 1 
ATOM   2532 C  CD1 . ILE A 1 359 ? 87.496  85.505  116.064 1.00 79.53  ? 359 ILE A CD1 1 
ATOM   2533 N  N   . ALA A 1 360 ? 84.907  89.638  113.570 1.00 80.27  ? 360 ALA A N   1 
ATOM   2534 C  CA  . ALA A 1 360 ? 84.761  90.873  112.812 1.00 80.27  ? 360 ALA A CA  1 
ATOM   2535 C  C   . ALA A 1 360 ? 84.180  92.015  113.636 1.00 80.27  ? 360 ALA A C   1 
ATOM   2536 O  O   . ALA A 1 360 ? 84.092  93.138  113.130 1.00 80.27  ? 360 ALA A O   1 
ATOM   2537 C  CB  . ALA A 1 360 ? 83.885  90.632  111.581 1.00 80.27  ? 360 ALA A CB  1 
ATOM   2538 N  N   . ASP A 1 361 ? 83.784  91.760  114.883 1.00 83.70  ? 361 ASP A N   1 
ATOM   2539 C  CA  . ASP A 1 361 ? 83.206  92.779  115.751 1.00 83.70  ? 361 ASP A CA  1 
ATOM   2540 C  C   . ASP A 1 361 ? 84.182  93.247  116.825 1.00 83.70  ? 361 ASP A C   1 
ATOM   2541 O  O   . ASP A 1 361 ? 83.759  93.709  117.890 1.00 83.70  ? 361 ASP A O   1 
ATOM   2542 C  CB  . ASP A 1 361 ? 81.923  92.260  116.396 1.00 83.70  ? 361 ASP A CB  1 
ATOM   2543 C  CG  . ASP A 1 361 ? 80.813  92.052  115.392 1.00 83.70  ? 361 ASP A CG  1 
ATOM   2544 O  OD1 . ASP A 1 361 ? 80.819  92.738  114.349 1.00 83.70  ? 361 ASP A OD1 1 
ATOM   2545 O  OD2 . ASP A 1 361 ? 79.932  91.205  115.648 1.00 83.70  ? 361 ASP A OD2 1 
ATOM   2546 N  N   . VAL A 1 362 ? 85.483  93.133  116.570 1.00 77.44  ? 362 VAL A N   1 
ATOM   2547 C  CA  . VAL A 1 362 ? 86.506  93.633  117.475 1.00 77.44  ? 362 VAL A CA  1 
ATOM   2548 C  C   . VAL A 1 362 ? 87.372  94.627  116.715 1.00 77.44  ? 362 VAL A C   1 
ATOM   2549 O  O   . VAL A 1 362 ? 87.434  94.622  115.485 1.00 77.44  ? 362 VAL A O   1 
ATOM   2550 C  CB  . VAL A 1 362 ? 87.374  92.511  118.078 1.00 77.44  ? 362 VAL A CB  1 
ATOM   2551 C  CG1 . VAL A 1 362 ? 86.522  91.536  118.848 1.00 77.44  ? 362 VAL A CG1 1 
ATOM   2552 C  CG2 . VAL A 1 362 ? 88.163  91.802  116.996 1.00 77.44  ? 362 VAL A CG2 1 
ATOM   2553 N  N   . ALA A 1 363 ? 88.048  95.481  117.475 1.00 71.44  ? 363 ALA A N   1 
ATOM   2554 C  CA  . ALA A 1 363 ? 88.976  96.484  116.949 1.00 71.44  ? 363 ALA A CA  1 
ATOM   2555 C  C   . ALA A 1 363 ? 88.237  97.337  115.918 1.00 71.44  ? 363 ALA A C   1 
ATOM   2556 O  O   . ALA A 1 363 ? 87.121  97.795  116.197 1.00 71.44  ? 363 ALA A O   1 
ATOM   2557 C  CB  . ALA A 1 363 ? 90.224  95.778  116.448 1.00 71.44  ? 363 ALA A CB  1 
ATOM   2558 N  N   . GLU A 1 364 ? 88.796  97.562  114.733 1.00 70.67  ? 364 GLU A N   1 
ATOM   2559 C  CA  . GLU A 1 364 ? 88.264  98.556  113.817 1.00 70.67  ? 364 GLU A CA  1 
ATOM   2560 C  C   . GLU A 1 364 ? 88.526  98.130  112.382 1.00 70.67  ? 364 GLU A C   1 
ATOM   2561 O  O   . GLU A 1 364 ? 89.619  97.662  112.057 1.00 70.67  ? 364 GLU A O   1 
ATOM   2562 C  CB  . GLU A 1 364 ? 88.896  99.926  114.086 1.00 70.67  ? 364 GLU A CB  1 
ATOM   2563 C  CG  . GLU A 1 364 ? 88.516  101.011 113.102 1.00 70.67  ? 364 GLU A CG  1 
ATOM   2564 C  CD  . GLU A 1 364 ? 89.204  102.322 113.405 1.00 70.67  ? 364 GLU A CD  1 
ATOM   2565 O  OE1 . GLU A 1 364 ? 89.954  102.378 114.398 1.00 70.67  ? 364 GLU A OE1 1 
ATOM   2566 O  OE2 . GLU A 1 364 ? 89.004  103.293 112.649 1.00 70.67  ? 364 GLU A OE2 1 
ATOM   2567 N  N   . SER A 1 365 ? 87.520  98.305  111.527 1.00 69.56  ? 365 SER A N   1 
ATOM   2568 C  CA  . SER A 1 365 ? 87.694  98.078  110.099 1.00 69.56  ? 365 SER A CA  1 
ATOM   2569 C  C   . SER A 1 365 ? 88.284  99.320  109.449 1.00 69.56  ? 365 SER A C   1 
ATOM   2570 O  O   . SER A 1 365 ? 87.723  99.852  108.487 1.00 69.56  ? 365 SER A O   1 
ATOM   2571 C  CB  . SER A 1 365 ? 86.364  97.708  109.442 1.00 69.56  ? 365 SER A CB  1 
ATOM   2572 O  OG  . SER A 1 365 ? 85.744  96.636  110.125 1.00 69.56  ? 365 SER A OG  1 
ATOM   2573 N  N   . GLY A 1 366 ? 89.413  99.789  109.970 1.00 66.62  ? 366 GLY A N   1 
ATOM   2574 C  CA  . GLY A 1 366 ? 90.036  100.992 109.478 1.00 66.62  ? 366 GLY A CA  1 
ATOM   2575 C  C   . GLY A 1 366 ? 91.493  101.090 109.875 1.00 66.62  ? 366 GLY A C   1 
ATOM   2576 O  O   . GLY A 1 366 ? 92.097  100.129 110.359 1.00 66.62  ? 366 GLY A O   1 
ATOM   2577 N  N   . PRO A 1 367 ? 92.086  102.270 109.679 1.00 63.35  ? 367 PRO A N   1 
ATOM   2578 C  CA  . PRO A 1 367 ? 93.526  102.432 109.934 1.00 63.35  ? 367 PRO A CA  1 
ATOM   2579 C  C   . PRO A 1 367 ? 93.934  102.278 111.392 1.00 63.35  ? 367 PRO A C   1 
ATOM   2580 O  O   . PRO A 1 367 ? 95.137  102.289 111.676 1.00 63.35  ? 367 PRO A O   1 
ATOM   2581 C  CB  . PRO A 1 367 ? 93.808  103.854 109.432 1.00 63.35  ? 367 PRO A CB  1 
ATOM   2582 C  CG  . PRO A 1 367 ? 92.706  104.128 108.454 1.00 63.35  ? 367 PRO A CG  1 
ATOM   2583 C  CD  . PRO A 1 367 ? 91.506  103.463 109.044 1.00 63.35  ? 367 PRO A CD  1 
ATOM   2584 N  N   . GLY A 1 368 ? 92.991  102.136 112.317 1.00 65.13  ? 368 GLY A N   1 
ATOM   2585 C  CA  . GLY A 1 368 ? 93.345  102.009 113.717 1.00 65.13  ? 368 GLY A CA  1 
ATOM   2586 C  C   . GLY A 1 368 ? 93.517  100.595 114.225 1.00 65.13  ? 368 GLY A C   1 
ATOM   2587 O  O   . GLY A 1 368 ? 93.580  100.403 115.442 1.00 65.13  ? 368 GLY A O   1 
ATOM   2588 N  N   . LEU A 1 369 ? 93.584  99.601  113.335 1.00 63.43  ? 369 LEU A N   1 
ATOM   2589 C  CA  . LEU A 1 369 ? 93.701  98.214  113.779 1.00 63.43  ? 369 LEU A CA  1 
ATOM   2590 C  C   . LEU A 1 369 ? 95.026  97.964  114.493 1.00 63.43  ? 369 LEU A C   1 
ATOM   2591 O  O   . LEU A 1 369 ? 95.064  97.321  115.548 1.00 63.43  ? 369 LEU A O   1 
ATOM   2592 C  CB  . LEU A 1 369 ? 93.548  97.266  112.590 1.00 63.43  ? 369 LEU A CB  1 
ATOM   2593 C  CG  . LEU A 1 369 ? 93.582  95.774  112.938 1.00 63.43  ? 369 LEU A CG  1 
ATOM   2594 C  CD1 . LEU A 1 369 ? 92.337  95.357  113.687 1.00 63.43  ? 369 LEU A CD1 1 
ATOM   2595 C  CD2 . LEU A 1 369 ? 93.767  94.921  111.703 1.00 63.43  ? 369 LEU A CD2 1 
ATOM   2596 N  N   . ALA A 1 370 ? 96.129  98.455  113.921 1.00 66.87  ? 370 ALA A N   1 
ATOM   2597 C  CA  . ALA A 1 370 ? 97.441  98.217  114.516 1.00 66.87  ? 370 ALA A CA  1 
ATOM   2598 C  C   . ALA A 1 370 ? 97.567  98.868  115.886 1.00 66.87  ? 370 ALA A C   1 
ATOM   2599 O  O   . ALA A 1 370 ? 98.055  98.236  116.832 1.00 66.87  ? 370 ALA A O   1 
ATOM   2600 C  CB  . ALA A 1 370 ? 98.539  98.729  113.584 1.00 66.87  ? 370 ALA A CB  1 
ATOM   2601 N  N   . PHE A 1 371 ? 97.121  100.118 116.015 1.00 66.76  ? 371 PHE A N   1 
ATOM   2602 C  CA  . PHE A 1 371 ? 97.182  100.865 117.264 1.00 66.76  ? 371 PHE A CA  1 
ATOM   2603 C  C   . PHE A 1 371 ? 96.204  100.350 118.311 1.00 66.76  ? 371 PHE A C   1 
ATOM   2604 O  O   . PHE A 1 371 ? 96.120  100.933 119.396 1.00 66.76  ? 371 PHE A O   1 
ATOM   2605 C  CB  . PHE A 1 371 ? 96.925  102.350 117.006 1.00 66.76  ? 371 PHE A CB  1 
ATOM   2606 C  CG  . PHE A 1 371 ? 97.878  102.973 116.027 1.00 66.76  ? 371 PHE A CG  1 
ATOM   2607 C  CD1 . PHE A 1 371 ? 99.084  103.498 116.453 1.00 66.76  ? 371 PHE A CD1 1 
ATOM   2608 C  CD2 . PHE A 1 371 ? 97.563  103.049 114.684 1.00 66.76  ? 371 PHE A CD2 1 
ATOM   2609 C  CE1 . PHE A 1 371 ? 99.960  104.079 115.561 1.00 66.76  ? 371 PHE A CE1 1 
ATOM   2610 C  CE2 . PHE A 1 371 ? 98.438  103.628 113.786 1.00 66.76  ? 371 PHE A CE2 1 
ATOM   2611 C  CZ  . PHE A 1 371 ? 99.638  104.143 114.226 1.00 66.76  ? 371 PHE A CZ  1 
ATOM   2612 N  N   . ILE A 1 372 ? 95.457  99.290  118.008 1.00 67.23  ? 372 ILE A N   1 
ATOM   2613 C  CA  . ILE A 1 372 ? 94.632  98.590  118.984 1.00 67.23  ? 372 ILE A CA  1 
ATOM   2614 C  C   . ILE A 1 372 ? 95.197  97.208  119.288 1.00 67.23  ? 372 ILE A C   1 
ATOM   2615 O  O   . ILE A 1 372 ? 95.192  96.759  120.438 1.00 67.23  ? 372 ILE A O   1 
ATOM   2616 C  CB  . ILE A 1 372 ? 93.162  98.489  118.511 1.00 67.23  ? 372 ILE A CB  1 
ATOM   2617 C  CG1 . ILE A 1 372 ? 92.499  99.866  118.518 1.00 67.23  ? 372 ILE A CG1 1 
ATOM   2618 C  CG2 . ILE A 1 372 ? 92.371  97.532  119.388 1.00 67.23  ? 372 ILE A CG2 1 
ATOM   2619 C  CD1 . ILE A 1 372 ? 91.283  99.959  117.628 1.00 67.23  ? 372 ILE A CD1 1 
ATOM   2620 N  N   . ALA A 1 373 ? 95.716  96.526  118.265 1.00 70.11  ? 373 ALA A N   1 
ATOM   2621 C  CA  . ALA A 1 373 ? 96.222  95.171  118.456 1.00 70.11  ? 373 ALA A CA  1 
ATOM   2622 C  C   . ALA A 1 373 ? 97.585  95.174  119.138 1.00 70.11  ? 373 ALA A C   1 
ATOM   2623 O  O   . ALA A 1 373 ? 97.775  94.513  120.165 1.00 70.11  ? 373 ALA A O   1 
ATOM   2624 C  CB  . ALA A 1 373 ? 96.291  94.444  117.113 1.00 70.11  ? 373 ALA A CB  1 
ATOM   2625 N  N   . TYR A 1 374 ? 98.551  95.908  118.580 1.00 70.62  ? 374 TYR A N   1 
ATOM   2626 C  CA  . TYR A 1 374 ? 99.912  95.853  119.113 1.00 70.62  ? 374 TYR A CA  1 
ATOM   2627 C  C   . TYR A 1 374 ? 100.032 96.381  120.539 1.00 70.62  ? 374 TYR A C   1 
ATOM   2628 O  O   . TYR A 1 374 ? 100.711 95.731  121.354 1.00 70.62  ? 374 TYR A O   1 
ATOM   2629 C  CB  . TYR A 1 374 ? 100.864 96.574  118.155 1.00 70.62  ? 374 TYR A CB  1 
ATOM   2630 C  CG  . TYR A 1 374 ? 101.144 95.791  116.893 1.00 70.62  ? 374 TYR A CG  1 
ATOM   2631 C  CD1 . TYR A 1 374 ? 101.406 94.428  116.944 1.00 70.62  ? 374 TYR A CD1 1 
ATOM   2632 C  CD2 . TYR A 1 374 ? 101.146 96.410  115.651 1.00 70.62  ? 374 TYR A CD2 1 
ATOM   2633 C  CE1 . TYR A 1 374 ? 101.660 93.707  115.796 1.00 70.62  ? 374 TYR A CE1 1 
ATOM   2634 C  CE2 . TYR A 1 374 ? 101.401 95.698  114.499 1.00 70.62  ? 374 TYR A CE2 1 
ATOM   2635 C  CZ  . TYR A 1 374 ? 101.658 94.347  114.577 1.00 70.62  ? 374 TYR A CZ  1 
ATOM   2636 O  OH  . TYR A 1 374 ? 101.912 93.633  113.429 1.00 70.62  ? 374 TYR A OH  1 
ATOM   2637 N  N   . PRO A 1 375 ? 99.452  97.534  120.908 1.00 70.59  ? 375 PRO A N   1 
ATOM   2638 C  CA  . PRO A 1 375 ? 99.505  97.933  122.325 1.00 70.59  ? 375 PRO A CA  1 
ATOM   2639 C  C   . PRO A 1 375 ? 98.887  96.912  123.263 1.00 70.59  ? 375 PRO A C   1 
ATOM   2640 O  O   . PRO A 1 375 ? 99.404  96.692  124.367 1.00 70.59  ? 375 PRO A O   1 
ATOM   2641 C  CB  . PRO A 1 375 ? 98.735  99.259  122.337 1.00 70.59  ? 375 PRO A CB  1 
ATOM   2642 C  CG  . PRO A 1 375 ? 98.912  99.793  120.973 1.00 70.59  ? 375 PRO A CG  1 
ATOM   2643 C  CD  . PRO A 1 375 ? 98.860  98.598  120.078 1.00 70.59  ? 375 PRO A CD  1 
ATOM   2644 N  N   . LYS A 1 376 ? 97.798  96.264  122.846 1.00 70.76  ? 376 LYS A N   1 
ATOM   2645 C  CA  . LYS A 1 376 ? 97.216  95.210  123.669 1.00 70.76  ? 376 LYS A CA  1 
ATOM   2646 C  C   . LYS A 1 376 ? 98.186  94.047  123.829 1.00 70.76  ? 376 LYS A C   1 
ATOM   2647 O  O   . LYS A 1 376 ? 98.219  93.395  124.879 1.00 70.76  ? 376 LYS A O   1 
ATOM   2648 C  CB  . LYS A 1 376 ? 95.895  94.738  123.064 1.00 70.76  ? 376 LYS A CB  1 
ATOM   2649 C  CG  . LYS A 1 376 ? 95.142  93.753  123.937 1.00 70.76  ? 376 LYS A CG  1 
ATOM   2650 C  CD  . LYS A 1 376 ? 94.584  94.437  125.168 1.00 70.76  ? 376 LYS A CD  1 
ATOM   2651 C  CE  . LYS A 1 376 ? 93.947  93.440  126.113 1.00 70.76  ? 376 LYS A CE  1 
ATOM   2652 N  NZ  . LYS A 1 376 ? 93.162  92.415  125.384 1.00 70.76  ? 376 LYS A NZ  1 
ATOM   2653 N  N   . ALA A 1 377 ? 98.983  93.769  122.795 1.00 73.05  ? 377 ALA A N   1 
ATOM   2654 C  CA  . ALA A 1 377 ? 99.988  92.716  122.895 1.00 73.05  ? 377 ALA A CA  1 
ATOM   2655 C  C   . ALA A 1 377 ? 101.087 93.097  123.879 1.00 73.05  ? 377 ALA A C   1 
ATOM   2656 O  O   . ALA A 1 377 ? 101.438 92.313  124.768 1.00 73.05  ? 377 ALA A O   1 
ATOM   2657 C  CB  . ALA A 1 377 ? 100.578 92.423  121.516 1.00 73.05  ? 377 ALA A CB  1 
ATOM   2658 N  N   . VAL A 1 378 ? 101.639 94.306  123.742 1.00 72.44  ? 378 VAL A N   1 
ATOM   2659 C  CA  . VAL A 1 378 ? 102.733 94.725  124.614 1.00 72.44  ? 378 VAL A CA  1 
ATOM   2660 C  C   . VAL A 1 378 ? 102.283 94.972  126.043 1.00 72.44  ? 378 VAL A C   1 
ATOM   2661 O  O   . VAL A 1 378 ? 103.128 95.065  126.938 1.00 72.44  ? 378 VAL A O   1 
ATOM   2662 C  CB  . VAL A 1 378 ? 103.438 95.990  124.083 1.00 72.44  ? 378 VAL A CB  1 
ATOM   2663 C  CG1 . VAL A 1 378 ? 103.810 95.819  122.624 1.00 72.44  ? 378 VAL A CG1 1 
ATOM   2664 C  CG2 . VAL A 1 378 ? 102.571 97.214  124.285 1.00 72.44  ? 378 VAL A CG2 1 
ATOM   2665 N  N   . THR A 1 379 ? 100.976 95.087  126.282 1.00 74.77  ? 379 THR A N   1 
ATOM   2666 C  CA  . THR A 1 379 ? 100.478 95.206  127.647 1.00 74.77  ? 379 THR A CA  1 
ATOM   2667 C  C   . THR A 1 379 ? 100.767 93.969  128.495 1.00 74.77  ? 379 THR A C   1 
ATOM   2668 O  O   . THR A 1 379 ? 100.850 94.087  129.723 1.00 74.77  ? 379 THR A O   1 
ATOM   2669 C  CB  . THR A 1 379 ? 98.973  95.495  127.611 1.00 74.77  ? 379 THR A CB  1 
ATOM   2670 O  OG1 . THR A 1 379 ? 98.741  96.697  126.866 1.00 74.77  ? 379 THR A OG1 1 
ATOM   2671 C  CG2 . THR A 1 379 ? 98.405  95.677  129.009 1.00 74.77  ? 379 THR A CG2 1 
ATOM   2672 N  N   . MET A 1 380 ? 100.959 92.799  127.881 1.00 80.27  ? 380 MET A N   1 
ATOM   2673 C  CA  . MET A 1 380 ? 101.165 91.560  128.622 1.00 80.27  ? 380 MET A CA  1 
ATOM   2674 C  C   . MET A 1 380 ? 102.599 91.048  128.617 1.00 80.27  ? 380 MET A C   1 
ATOM   2675 O  O   . MET A 1 380 ? 102.881 90.064  129.310 1.00 80.27  ? 380 MET A O   1 
ATOM   2676 C  CB  . MET A 1 380 ? 100.245 90.458  128.077 1.00 80.27  ? 380 MET A CB  1 
ATOM   2677 C  CG  . MET A 1 380 ? 98.771  90.720  128.317 1.00 80.27  ? 380 MET A CG  1 
ATOM   2678 S  SD  . MET A 1 380 ? 97.740  89.379  127.716 1.00 80.27  ? 380 MET A SD  1 
ATOM   2679 C  CE  . MET A 1 380 ? 97.858  89.682  125.958 1.00 80.27  ? 380 MET A CE  1 
ATOM   2680 N  N   . MET A 1 381 ? 103.503 91.663  127.862 1.00 79.33  ? 381 MET A N   1 
ATOM   2681 C  CA  . MET A 1 381 ? 104.908 91.281  127.922 1.00 79.33  ? 381 MET A CA  1 
ATOM   2682 C  C   . MET A 1 381 ? 105.510 91.723  129.255 1.00 79.33  ? 381 MET A C   1 
ATOM   2683 O  O   . MET A 1 381 ? 105.069 92.722  129.829 1.00 79.33  ? 381 MET A O   1 
ATOM   2684 C  CB  . MET A 1 381 ? 105.686 91.916  126.772 1.00 79.33  ? 381 MET A CB  1 
ATOM   2685 C  CG  . MET A 1 381 ? 105.314 91.399  125.397 1.00 79.33  ? 381 MET A CG  1 
ATOM   2686 S  SD  . MET A 1 381 ? 106.270 92.207  124.104 1.00 79.33  ? 381 MET A SD  1 
ATOM   2687 C  CE  . MET A 1 381 ? 105.557 91.482  122.634 1.00 79.33  ? 381 MET A CE  1 
ATOM   2688 N  N   . PRO A 1 382 ? 106.497 90.996  129.779 1.00 81.79  ? 382 PRO A N   1 
ATOM   2689 C  CA  . PRO A 1 382 ? 107.157 91.437  131.014 1.00 81.79  ? 382 PRO A CA  1 
ATOM   2690 C  C   . PRO A 1 382 ? 107.827 92.790  130.822 1.00 81.79  ? 382 PRO A C   1 
ATOM   2691 O  O   . PRO A 1 382 ? 108.425 93.061  129.780 1.00 81.79  ? 382 PRO A O   1 
ATOM   2692 C  CB  . PRO A 1 382 ? 108.181 90.329  131.284 1.00 81.79  ? 382 PRO A CB  1 
ATOM   2693 C  CG  . PRO A 1 382 ? 107.654 89.140  130.557 1.00 81.79  ? 382 PRO A CG  1 
ATOM   2694 C  CD  . PRO A 1 382 ? 106.989 89.684  129.329 1.00 81.79  ? 382 PRO A CD  1 
ATOM   2695 N  N   . LEU A 1 383 ? 107.730 93.640  131.850 1.00 81.14  ? 383 LEU A N   1 
ATOM   2696 C  CA  . LEU A 1 383 ? 108.197 95.022  131.786 1.00 81.14  ? 383 LEU A CA  1 
ATOM   2697 C  C   . LEU A 1 383 ? 107.548 95.726  130.600 1.00 81.14  ? 383 LEU A C   1 
ATOM   2698 O  O   . LEU A 1 383 ? 108.228 96.027  129.611 1.00 81.14  ? 383 LEU A O   1 
ATOM   2699 C  CB  . LEU A 1 383 ? 109.724 95.092  131.682 1.00 81.14  ? 383 LEU A CB  1 
ATOM   2700 C  CG  . LEU A 1 383 ? 110.569 94.993  132.958 1.00 81.14  ? 383 LEU A CG  1 
ATOM   2701 C  CD1 . LEU A 1 383 ? 110.294 96.172  133.880 1.00 81.14  ? 383 LEU A CD1 1 
ATOM   2702 C  CD2 . LEU A 1 383 ? 110.363 93.672  133.688 1.00 81.14  ? 383 LEU A CD2 1 
ATOM   2703 N  N   . PRO A 1 384 ? 106.239 95.996  130.658 1.00 77.77  ? 384 PRO A N   1 
ATOM   2704 C  CA  . PRO A 1 384 ? 105.533 96.493  129.463 1.00 77.77  ? 384 PRO A CA  1 
ATOM   2705 C  C   . PRO A 1 384 ? 106.081 97.792  128.899 1.00 77.77  ? 384 PRO A C   1 
ATOM   2706 O  O   . PRO A 1 384 ? 106.058 97.978  127.677 1.00 77.77  ? 384 PRO A O   1 
ATOM   2707 C  CB  . PRO A 1 384 ? 104.092 96.662  129.966 1.00 77.77  ? 384 PRO A CB  1 
ATOM   2708 C  CG  . PRO A 1 384 ? 103.988 95.744  131.135 1.00 77.77  ? 384 PRO A CG  1 
ATOM   2709 C  CD  . PRO A 1 384 ? 105.325 95.808  131.796 1.00 77.77  ? 384 PRO A CD  1 
ATOM   2710 N  N   . THR A 1 385 ? 106.563 98.700  129.750 1.00 75.51  ? 385 THR A N   1 
ATOM   2711 C  CA  . THR A 1 385 ? 107.041 99.993  129.269 1.00 75.51  ? 385 THR A CA  1 
ATOM   2712 C  C   . THR A 1 385 ? 108.256 99.832  128.361 1.00 75.51  ? 385 THR A C   1 
ATOM   2713 O  O   . THR A 1 385 ? 108.366 100.494 127.322 1.00 75.51  ? 385 THR A O   1 
ATOM   2714 C  CB  . THR A 1 385 ? 107.367 100.901 130.455 1.00 75.51  ? 385 THR A CB  1 
ATOM   2715 O  OG1 . THR A 1 385 ? 106.162 101.210 131.164 1.00 75.51  ? 385 THR A OG1 1 
ATOM   2716 C  CG2 . THR A 1 385 ? 108.006 102.196 129.977 1.00 75.51  ? 385 THR A CG2 1 
ATOM   2717 N  N   . PHE A 1 386 ? 109.180 98.947  128.742 1.00 73.48  ? 386 PHE A N   1 
ATOM   2718 C  CA  . PHE A 1 386 ? 110.394 98.728  127.961 1.00 73.48  ? 386 PHE A CA  1 
ATOM   2719 C  C   . PHE A 1 386 ? 110.064 98.196  126.570 1.00 73.48  ? 386 PHE A C   1 
ATOM   2720 O  O   . PHE A 1 386 ? 110.552 98.712  125.555 1.00 73.48  ? 386 PHE A O   1 
ATOM   2721 C  CB  . PHE A 1 386 ? 111.309 97.762  128.721 1.00 73.48  ? 386 PHE A CB  1 
ATOM   2722 C  CG  . PHE A 1 386 ? 112.538 97.353  127.963 1.00 73.48  ? 386 PHE A CG  1 
ATOM   2723 C  CD1 . PHE A 1 386 ? 112.767 96.021  127.663 1.00 73.48  ? 386 PHE A CD1 1 
ATOM   2724 C  CD2 . PHE A 1 386 ? 113.474 98.293  127.569 1.00 73.48  ? 386 PHE A CD2 1 
ATOM   2725 C  CE1 . PHE A 1 386 ? 113.898 95.637  126.973 1.00 73.48  ? 386 PHE A CE1 1 
ATOM   2726 C  CE2 . PHE A 1 386 ? 114.608 97.914  126.878 1.00 73.48  ? 386 PHE A CE2 1 
ATOM   2727 C  CZ  . PHE A 1 386 ? 114.820 96.584  126.581 1.00 73.48  ? 386 PHE A CZ  1 
ATOM   2728 N  N   . TRP A 1 387 ? 109.216 97.167  126.506 1.00 71.65  ? 387 TRP A N   1 
ATOM   2729 C  CA  . TRP A 1 387 ? 108.849 96.597  125.216 1.00 71.65  ? 387 TRP A CA  1 
ATOM   2730 C  C   . TRP A 1 387 ? 108.015 97.568  124.395 1.00 71.65  ? 387 TRP A C   1 
ATOM   2731 O  O   . TRP A 1 387 ? 108.116 97.583  123.166 1.00 71.65  ? 387 TRP A O   1 
ATOM   2732 C  CB  . TRP A 1 387 ? 108.100 95.280  125.414 1.00 71.65  ? 387 TRP A CB  1 
ATOM   2733 C  CG  . TRP A 1 387 ? 108.987 94.130  125.793 1.00 71.65  ? 387 TRP A CG  1 
ATOM   2734 C  CD1 . TRP A 1 387 ? 108.902 93.374  126.923 1.00 71.65  ? 387 TRP A CD1 1 
ATOM   2735 C  CD2 . TRP A 1 387 ? 110.091 93.606  125.045 1.00 71.65  ? 387 TRP A CD2 1 
ATOM   2736 N  NE1 . TRP A 1 387 ? 109.881 92.412  126.927 1.00 71.65  ? 387 TRP A NE1 1 
ATOM   2737 C  CE2 . TRP A 1 387 ? 110.625 92.534  125.784 1.00 71.65  ? 387 TRP A CE2 1 
ATOM   2738 C  CE3 . TRP A 1 387 ? 110.680 93.940  123.824 1.00 71.65  ? 387 TRP A CE3 1 
ATOM   2739 C  CZ2 . TRP A 1 387 ? 111.718 91.794  125.342 1.00 71.65  ? 387 TRP A CZ2 1 
ATOM   2740 C  CZ3 . TRP A 1 387 ? 111.763 93.204  123.387 1.00 71.65  ? 387 TRP A CZ3 1 
ATOM   2741 C  CH2 . TRP A 1 387 ? 112.271 92.145  124.143 1.00 71.65  ? 387 TRP A CH2 1 
ATOM   2742 N  N   . SER A 1 388 ? 107.188 98.385  125.051 1.00 71.78  ? 388 SER A N   1 
ATOM   2743 C  CA  . SER A 1 388 ? 106.429 99.407  124.337 1.00 71.78  ? 388 SER A CA  1 
ATOM   2744 C  C   . SER A 1 388 ? 107.358 100.424 123.687 1.00 71.78  ? 388 SER A C   1 
ATOM   2745 O  O   . SER A 1 388 ? 107.177 100.794 122.520 1.00 71.78  ? 388 SER A O   1 
ATOM   2746 C  CB  . SER A 1 388 ? 105.462 100.099 125.296 1.00 71.78  ? 388 SER A CB  1 
ATOM   2747 O  OG  . SER A 1 388 ? 104.748 101.127 124.636 1.00 71.78  ? 388 SER A OG  1 
ATOM   2748 N  N   . ILE A 1 389 ? 108.370 100.880 124.430 1.00 70.22  ? 389 ILE A N   1 
ATOM   2749 C  CA  . ILE A 1 389 ? 109.331 101.825 123.872 1.00 70.22  ? 389 ILE A CA  1 
ATOM   2750 C  C   . ILE A 1 389 ? 110.073 101.195 122.703 1.00 70.22  ? 389 ILE A C   1 
ATOM   2751 O  O   . ILE A 1 389 ? 110.263 101.827 121.659 1.00 70.22  ? 389 ILE A O   1 
ATOM   2752 C  CB  . ILE A 1 389 ? 110.305 102.315 124.959 1.00 70.22  ? 389 ILE A CB  1 
ATOM   2753 C  CG1 . ILE A 1 389 ? 109.567 103.130 126.018 1.00 70.22  ? 389 ILE A CG1 1 
ATOM   2754 C  CG2 . ILE A 1 389 ? 111.414 103.154 124.345 1.00 70.22  ? 389 ILE A CG2 1 
ATOM   2755 C  CD1 . ILE A 1 389 ? 110.446 103.572 127.159 1.00 70.22  ? 389 ILE A CD1 1 
ATOM   2756 N  N   . LEU A 1 390 ? 110.496 99.935  122.855 1.00 73.90  ? 390 LEU A N   1 
ATOM   2757 C  CA  . LEU A 1 390 ? 111.213 99.265  121.771 1.00 73.90  ? 390 LEU A CA  1 
ATOM   2758 C  C   . LEU A 1 390 ? 110.336 99.106  120.533 1.00 73.90  ? 390 LEU A C   1 
ATOM   2759 O  O   . LEU A 1 390 ? 110.793 99.333  119.405 1.00 73.90  ? 390 LEU A O   1 
ATOM   2760 C  CB  . LEU A 1 390 ? 111.726 97.905  122.241 1.00 73.90  ? 390 LEU A CB  1 
ATOM   2761 C  CG  . LEU A 1 390 ? 112.929 97.917  123.184 1.00 73.90  ? 390 LEU A CG  1 
ATOM   2762 C  CD1 . LEU A 1 390 ? 113.528 96.530  123.287 1.00 73.90  ? 390 LEU A CD1 1 
ATOM   2763 C  CD2 . LEU A 1 390 ? 113.968 98.915  122.712 1.00 73.90  ? 390 LEU A CD2 1 
ATOM   2764 N  N   . PHE A 1 391 ? 109.072 98.717  120.724 1.00 71.59  ? 391 PHE A N   1 
ATOM   2765 C  CA  . PHE A 1 391 ? 108.174 98.532  119.590 1.00 71.59  ? 391 PHE A CA  1 
ATOM   2766 C  C   . PHE A 1 391 ? 107.917 99.844  118.866 1.00 71.59  ? 391 PHE A C   1 
ATOM   2767 O  O   . PHE A 1 391 ? 107.922 99.890  117.631 1.00 71.59  ? 391 PHE A O   1 
ATOM   2768 C  CB  . PHE A 1 391 ? 106.852 97.918  120.046 1.00 71.59  ? 391 PHE A CB  1 
ATOM   2769 C  CG  . PHE A 1 391 ? 105.801 97.908  118.975 1.00 71.59  ? 391 PHE A CG  1 
ATOM   2770 C  CD1 . PHE A 1 391 ? 105.879 97.014  117.921 1.00 71.59  ? 391 PHE A CD1 1 
ATOM   2771 C  CD2 . PHE A 1 391 ? 104.749 98.806  119.008 1.00 71.59  ? 391 PHE A CD2 1 
ATOM   2772 C  CE1 . PHE A 1 391 ? 104.923 97.011  116.926 1.00 71.59  ? 391 PHE A CE1 1 
ATOM   2773 C  CE2 . PHE A 1 391 ? 103.790 98.807  118.014 1.00 71.59  ? 391 PHE A CE2 1 
ATOM   2774 C  CZ  . PHE A 1 391 ? 103.879 97.910  116.973 1.00 71.59  ? 391 PHE A CZ  1 
ATOM   2775 N  N   . PHE A 1 392 ? 107.688 100.925 119.610 1.00 68.39  ? 392 PHE A N   1 
ATOM   2776 C  CA  . PHE A 1 392 ? 107.439 102.193 118.938 1.00 68.39  ? 392 PHE A CA  1 
ATOM   2777 C  C   . PHE A 1 392 ? 108.707 102.746 118.298 1.00 68.39  ? 392 PHE A C   1 
ATOM   2778 O  O   . PHE A 1 392 ? 108.632 103.401 117.253 1.00 68.39  ? 392 PHE A O   1 
ATOM   2779 C  CB  . PHE A 1 392 ? 106.805 103.185 119.910 1.00 68.39  ? 392 PHE A CB  1 
ATOM   2780 C  CG  . PHE A 1 392 ? 105.353 102.906 120.172 1.00 68.39  ? 392 PHE A CG  1 
ATOM   2781 C  CD1 . PHE A 1 392 ? 104.433 102.962 119.141 1.00 68.39  ? 392 PHE A CD1 1 
ATOM   2782 C  CD2 . PHE A 1 392 ? 104.912 102.556 121.434 1.00 68.39  ? 392 PHE A CD2 1 
ATOM   2783 C  CE1 . PHE A 1 392 ? 103.101 102.690 119.365 1.00 68.39  ? 392 PHE A CE1 1 
ATOM   2784 C  CE2 . PHE A 1 392 ? 103.578 102.286 121.665 1.00 68.39  ? 392 PHE A CE2 1 
ATOM   2785 C  CZ  . PHE A 1 392 ? 102.674 102.352 120.628 1.00 68.39  ? 392 PHE A CZ  1 
ATOM   2786 N  N   . ILE A 1 393 ? 109.879 102.450 118.869 1.00 73.62  ? 393 ILE A N   1 
ATOM   2787 C  CA  . ILE A 1 393 ? 111.134 102.847 118.235 1.00 73.62  ? 393 ILE A CA  1 
ATOM   2788 C  C   . ILE A 1 393 ? 111.320 102.122 116.907 1.00 73.62  ? 393 ILE A C   1 
ATOM   2789 O  O   . ILE A 1 393 ? 111.697 102.733 115.900 1.00 73.62  ? 393 ILE A O   1 
ATOM   2790 C  CB  . ILE A 1 393 ? 112.320 102.600 119.186 1.00 73.62  ? 393 ILE A CB  1 
ATOM   2791 C  CG1 . ILE A 1 393 ? 112.415 103.717 120.225 1.00 73.62  ? 393 ILE A CG1 1 
ATOM   2792 C  CG2 . ILE A 1 393 ? 113.623 102.504 118.414 1.00 73.62  ? 393 ILE A CG2 1 
ATOM   2793 C  CD1 . ILE A 1 393 ? 113.469 103.475 121.278 1.00 73.62  ? 393 ILE A CD1 1 
ATOM   2794 N  N   . MET A 1 394 ? 111.066 100.810 116.878 1.00 78.95  ? 394 MET A N   1 
ATOM   2795 C  CA  . MET A 1 394 ? 111.236 100.085 115.620 1.00 78.95  ? 394 MET A CA  1 
ATOM   2796 C  C   . MET A 1 394 ? 110.172 100.478 114.605 1.00 78.95  ? 394 MET A C   1 
ATOM   2797 O  O   . MET A 1 394 ? 110.450 100.516 113.401 1.00 78.95  ? 394 MET A O   1 
ATOM   2798 C  CB  . MET A 1 394 ? 111.239 98.571  115.856 1.00 78.95  ? 394 MET A CB  1 
ATOM   2799 C  CG  . MET A 1 394 ? 109.980 97.975  116.455 1.00 78.95  ? 394 MET A CG  1 
ATOM   2800 S  SD  . MET A 1 394 ? 108.621 97.716  115.299 1.00 78.95  ? 394 MET A SD  1 
ATOM   2801 C  CE  . MET A 1 394 ? 109.257 96.356  114.328 1.00 78.95  ? 394 MET A CE  1 
ATOM   2802 N  N   . LEU A 1 395 ? 108.959 100.785 115.069 1.00 74.93  ? 395 LEU A N   1 
ATOM   2803 C  CA  . LEU A 1 395 ? 107.927 101.285 114.171 1.00 74.93  ? 395 LEU A CA  1 
ATOM   2804 C  C   . LEU A 1 395 ? 108.349 102.613 113.552 1.00 74.93  ? 395 LEU A C   1 
ATOM   2805 O  O   . LEU A 1 395 ? 108.178 102.831 112.345 1.00 74.93  ? 395 LEU A O   1 
ATOM   2806 C  CB  . LEU A 1 395 ? 106.615 101.430 114.942 1.00 74.93  ? 395 LEU A CB  1 
ATOM   2807 C  CG  . LEU A 1 395 ? 105.354 101.871 114.209 1.00 74.93  ? 395 LEU A CG  1 
ATOM   2808 C  CD1 . LEU A 1 395 ? 105.006 100.835 113.166 1.00 74.93  ? 395 LEU A CD1 1 
ATOM   2809 C  CD2 . LEU A 1 395 ? 104.207 102.052 115.183 1.00 74.93  ? 395 LEU A CD2 1 
ATOM   2810 N  N   . LEU A 1 396 ? 108.929 103.502 114.366 1.00 75.33  ? 396 LEU A N   1 
ATOM   2811 C  CA  . LEU A 1 396 ? 109.442 104.767 113.853 1.00 75.33  ? 396 LEU A CA  1 
ATOM   2812 C  C   . LEU A 1 396 ? 110.582 104.553 112.868 1.00 75.33  ? 396 LEU A C   1 
ATOM   2813 O  O   . LEU A 1 396 ? 110.672 105.259 111.863 1.00 75.33  ? 396 LEU A O   1 
ATOM   2814 C  CB  . LEU A 1 396 ? 109.896 105.660 115.007 1.00 75.33  ? 396 LEU A CB  1 
ATOM   2815 C  CG  . LEU A 1 396 ? 108.811 106.483 115.698 1.00 75.33  ? 396 LEU A CG  1 
ATOM   2816 C  CD1 . LEU A 1 396 ? 109.355 107.133 116.952 1.00 75.33  ? 396 LEU A CD1 1 
ATOM   2817 C  CD2 . LEU A 1 396 ? 108.283 107.537 114.744 1.00 75.33  ? 396 LEU A CD2 1 
ATOM   2818 N  N   . LEU A 1 397 ? 111.475 103.602 113.147 1.00 75.36  ? 397 LEU A N   1 
ATOM   2819 C  CA  . LEU A 1 397 ? 112.574 103.330 112.222 1.00 75.36  ? 397 LEU A CA  1 
ATOM   2820 C  C   . LEU A 1 397 ? 112.050 102.837 110.878 1.00 75.36  ? 397 LEU A C   1 
ATOM   2821 O  O   . LEU A 1 397 ? 112.471 103.317 109.815 1.00 75.36  ? 397 LEU A O   1 
ATOM   2822 C  CB  . LEU A 1 397 ? 113.532 102.304 112.828 1.00 75.36  ? 397 LEU A CB  1 
ATOM   2823 C  CG  . LEU A 1 397 ? 114.455 102.766 113.955 1.00 75.36  ? 397 LEU A CG  1 
ATOM   2824 C  CD1 . LEU A 1 397 ? 115.061 101.568 114.664 1.00 75.36  ? 397 LEU A CD1 1 
ATOM   2825 C  CD2 . LEU A 1 397 ? 115.541 103.679 113.415 1.00 75.36  ? 397 LEU A CD2 1 
ATOM   2826 N  N   . LEU A 1 398 ? 111.116 101.879 110.912 1.00 77.26  ? 398 LEU A N   1 
ATOM   2827 C  CA  . LEU A 1 398 ? 110.536 101.350 109.683 1.00 77.26  ? 398 LEU A CA  1 
ATOM   2828 C  C   . LEU A 1 398 ? 109.833 102.442 108.892 1.00 77.26  ? 398 LEU A C   1 
ATOM   2829 O  O   . LEU A 1 398 ? 109.976 102.521 107.666 1.00 77.26  ? 398 LEU A O   1 
ATOM   2830 C  CB  . LEU A 1 398 ? 109.555 100.223 110.005 1.00 77.26  ? 398 LEU A CB  1 
ATOM   2831 C  CG  . LEU A 1 398 ? 110.113 98.837  110.325 1.00 77.26  ? 398 LEU A CG  1 
ATOM   2832 C  CD1 . LEU A 1 398 ? 109.023 97.949  110.903 1.00 77.26  ? 398 LEU A CD1 1 
ATOM   2833 C  CD2 . LEU A 1 398 ? 110.723 98.204  109.090 1.00 77.26  ? 398 LEU A CD2 1 
ATOM   2834 N  N   . GLY A 1 399 ? 109.063 103.293 109.572 1.00 77.18  ? 399 GLY A N   1 
ATOM   2835 C  CA  . GLY A 1 399 ? 108.397 104.378 108.874 1.00 77.18  ? 399 GLY A CA  1 
ATOM   2836 C  C   . GLY A 1 399 ? 109.363 105.406 108.317 1.00 77.18  ? 399 GLY A C   1 
ATOM   2837 O  O   . GLY A 1 399 ? 109.217 105.850 107.176 1.00 77.18  ? 399 GLY A O   1 
ATOM   2838 N  N   . LEU A 1 400 ? 110.330 105.820 109.135 1.00 78.19  ? 400 LEU A N   1 
ATOM   2839 C  CA  . LEU A 1 400 ? 111.263 106.874 108.721 1.00 78.19  ? 400 LEU A CA  1 
ATOM   2840 C  C   . LEU A 1 400 ? 112.155 106.526 107.541 1.00 78.19  ? 400 LEU A C   1 
ATOM   2841 O  O   . LEU A 1 400 ? 112.299 107.336 106.637 1.00 78.19  ? 400 LEU A O   1 
ATOM   2842 C  CB  . LEU A 1 400 ? 112.116 107.356 109.898 1.00 78.19  ? 400 LEU A CB  1 
ATOM   2843 C  CG  . LEU A 1 400 ? 111.445 108.388 110.806 1.00 78.19  ? 400 LEU A CG  1 
ATOM   2844 C  CD1 . LEU A 1 400 ? 112.308 108.680 112.024 1.00 78.19  ? 400 LEU A CD1 1 
ATOM   2845 C  CD2 . LEU A 1 400 ? 111.148 109.663 110.033 1.00 78.19  ? 400 LEU A CD2 1 
ATOM   2846 N  N   . ASP A 1 401 ? 112.773 105.346 107.538 1.00 82.26  ? 401 ASP A N   1 
ATOM   2847 C  CA  . ASP A 1 401 ? 113.687 105.042 106.440 1.00 82.26  ? 401 ASP A CA  1 
ATOM   2848 C  C   . ASP A 1 401 ? 112.903 105.002 105.134 1.00 82.26  ? 401 ASP A C   1 
ATOM   2849 O  O   . ASP A 1 401 ? 113.407 105.441 104.109 1.00 82.26  ? 401 ASP A O   1 
ATOM   2850 C  CB  . ASP A 1 401 ? 114.572 103.802 106.689 1.00 82.26  ? 401 ASP A CB  1 
ATOM   2851 C  CG  . ASP A 1 401 ? 113.804 102.491 106.681 1.00 82.26  ? 401 ASP A CG  1 
ATOM   2852 O  OD1 . ASP A 1 401 ? 114.453 101.436 106.529 1.00 82.26  ? 401 ASP A OD1 1 
ATOM   2853 O  OD2 . ASP A 1 401 ? 112.573 102.494 106.829 1.00 82.26  ? 401 ASP A OD2 1 
ATOM   2854 N  N   . SER A 1 402 ? 111.669 104.504 105.167 1.00 80.20  ? 402 SER A N   1 
ATOM   2855 C  CA  . SER A 1 402 ? 110.824 104.537 103.980 1.00 80.20  ? 402 SER A CA  1 
ATOM   2856 C  C   . SER A 1 402 ? 110.532 105.989 103.618 1.00 80.20  ? 402 SER A C   1 
ATOM   2857 O  O   . SER A 1 402 ? 110.678 106.372 102.463 1.00 80.20  ? 402 SER A O   1 
ATOM   2858 C  CB  . SER A 1 402 ? 109.524 103.773 104.224 1.00 80.20  ? 402 SER A CB  1 
ATOM   2859 O  OG  . SER A 1 402 ? 109.786 102.427 104.583 1.00 80.20  ? 402 SER A OG  1 
ATOM   2860 N  N   . GLN A 1 403 ? 110.126 106.799 104.595 1.00 81.62  ? 403 GLN A N   1 
ATOM   2861 C  CA  . GLN A 1 403 ? 109.883 108.217 104.348 1.00 81.62  ? 403 GLN A CA  1 
ATOM   2862 C  C   . GLN A 1 403 ? 111.095 108.879 103.703 1.00 81.62  ? 403 GLN A C   1 
ATOM   2863 O  O   . GLN A 1 403 ? 110.952 109.660 102.755 1.00 81.62  ? 403 GLN A O   1 
ATOM   2864 C  CB  . GLN A 1 403 ? 109.518 108.916 105.659 1.00 81.62  ? 403 GLN A CB  1 
ATOM   2865 C  CG  . GLN A 1 403 ? 109.169 110.395 105.532 1.00 81.62  ? 403 GLN A CG  1 
ATOM   2866 C  CD  . GLN A 1 403 ? 107.873 110.647 104.782 1.00 81.62  ? 403 GLN A CD  1 
ATOM   2867 O  OE1 . GLN A 1 403 ? 107.882 111.092 103.637 1.00 81.62  ? 403 GLN A OE1 1 
ATOM   2868 N  NE2 . GLN A 1 403 ? 106.751 110.368 105.431 1.00 81.62  ? 403 GLN A NE2 1 
ATOM   2869 N  N   . PHE A 1 404 ? 112.296 108.566 104.197 1.00 84.67  ? 404 PHE A N   1 
ATOM   2870 C  CA  . PHE A 1 404 ? 113.513 109.108 103.602 1.00 84.67  ? 404 PHE A CA  1 
ATOM   2871 C  C   . PHE A 1 404 ? 113.631 108.685 102.148 1.00 84.67  ? 404 PHE A C   1 
ATOM   2872 O  O   . PHE A 1 404 ? 113.916 109.507 101.271 1.00 84.67  ? 404 PHE A O   1 
ATOM   2873 C  CB  . PHE A 1 404 ? 114.747 108.637 104.373 1.00 84.67  ? 404 PHE A CB  1 
ATOM   2874 C  CG  . PHE A 1 404 ? 114.862 109.203 105.752 1.00 84.67  ? 404 PHE A CG  1 
ATOM   2875 C  CD1 . PHE A 1 404 ? 114.517 110.514 106.011 1.00 84.67  ? 404 PHE A CD1 1 
ATOM   2876 C  CD2 . PHE A 1 404 ? 115.345 108.424 106.789 1.00 84.67  ? 404 PHE A CD2 1 
ATOM   2877 C  CE1 . PHE A 1 404 ? 114.626 111.029 107.283 1.00 84.67  ? 404 PHE A CE1 1 
ATOM   2878 C  CE2 . PHE A 1 404 ? 115.459 108.934 108.061 1.00 84.67  ? 404 PHE A CE2 1 
ATOM   2879 C  CZ  . PHE A 1 404 ? 115.099 110.238 108.309 1.00 84.67  ? 404 PHE A CZ  1 
ATOM   2880 N  N   . VAL A 1 405 ? 113.408 107.397 101.875 1.00 84.24  ? 405 VAL A N   1 
ATOM   2881 C  CA  . VAL A 1 405 ? 113.566 106.891 100.514 1.00 84.24  ? 405 VAL A CA  1 
ATOM   2882 C  C   . VAL A 1 405 ? 112.566 107.552 99.573  1.00 84.24  ? 405 VAL A C   1 
ATOM   2883 O  O   . VAL A 1 405 ? 112.917 107.957 98.459  1.00 84.24  ? 405 VAL A O   1 
ATOM   2884 C  CB  . VAL A 1 405 ? 113.441 105.357 100.491 1.00 84.24  ? 405 VAL A CB  1 
ATOM   2885 C  CG1 . VAL A 1 405 ? 113.435 104.848 99.059  1.00 84.24  ? 405 VAL A CG1 1 
ATOM   2886 C  CG2 . VAL A 1 405 ? 114.577 104.723 101.273 1.00 84.24  ? 405 VAL A CG2 1 
ATOM   2887 N  N   . GLU A 1 406 ? 111.306 107.679 100.002 1.00 86.75  ? 406 GLU A N   1 
ATOM   2888 C  CA  . GLU A 1 406 ? 110.288 108.254 99.125  1.00 86.75  ? 406 GLU A CA  1 
ATOM   2889 C  C   . GLU A 1 406 ? 110.508 109.746 98.902  1.00 86.75  ? 406 GLU A C   1 
ATOM   2890 O  O   . GLU A 1 406 ? 110.327 110.241 97.782  1.00 86.75  ? 406 GLU A O   1 
ATOM   2891 C  CB  . GLU A 1 406 ? 108.889 107.992 99.683  1.00 86.75  ? 406 GLU A CB  1 
ATOM   2892 C  CG  . GLU A 1 406 ? 108.595 106.532 100.003 1.00 86.75  ? 406 GLU A CG  1 
ATOM   2893 C  CD  . GLU A 1 406 ? 108.680 105.618 98.795  1.00 86.75  ? 406 GLU A CD  1 
ATOM   2894 O  OE1 . GLU A 1 406 ? 108.800 104.392 98.992  1.00 86.75  ? 406 GLU A OE1 1 
ATOM   2895 O  OE2 . GLU A 1 406 ? 108.606 106.114 97.652  1.00 86.75  ? 406 GLU A OE2 1 
ATOM   2896 N  N   . VAL A 1 407 ? 110.893 110.484 99.948  1.00 88.46  ? 407 VAL A N   1 
ATOM   2897 C  CA  . VAL A 1 407 ? 111.178 111.906 99.773  1.00 88.46  ? 407 VAL A CA  1 
ATOM   2898 C  C   . VAL A 1 407 ? 112.387 112.096 98.865  1.00 88.46  ? 407 VAL A C   1 
ATOM   2899 O  O   . VAL A 1 407 ? 112.400 112.983 98.003  1.00 88.46  ? 407 VAL A O   1 
ATOM   2900 C  CB  . VAL A 1 407 ? 111.375 112.589 101.138 1.00 88.46  ? 407 VAL A CB  1 
ATOM   2901 C  CG1 . VAL A 1 407 ? 111.884 114.007 100.955 1.00 88.46  ? 407 VAL A CG1 1 
ATOM   2902 C  CG2 . VAL A 1 407 ? 110.075 112.601 101.912 1.00 88.46  ? 407 VAL A CG2 1 
ATOM   2903 N  N   . GLU A 1 408 ? 113.419 111.265 99.038  1.00 90.24  ? 408 GLU A N   1 
ATOM   2904 C  CA  . GLU A 1 408 ? 114.584 111.341 98.165  1.00 90.24  ? 408 GLU A CA  1 
ATOM   2905 C  C   . GLU A 1 408 ? 114.208 111.034 96.722  1.00 90.24  ? 408 GLU A C   1 
ATOM   2906 O  O   . GLU A 1 408 ? 114.693 111.690 95.794  1.00 90.24  ? 408 GLU A O   1 
ATOM   2907 C  CB  . GLU A 1 408 ? 115.667 110.378 98.652  1.00 90.24  ? 408 GLU A CB  1 
ATOM   2908 C  CG  . GLU A 1 408 ? 116.492 110.893 99.818  1.00 90.24  ? 408 GLU A CG  1 
ATOM   2909 C  CD  . GLU A 1 408 ? 117.256 109.787 100.521 1.00 90.24  ? 408 GLU A CD  1 
ATOM   2910 O  OE1 . GLU A 1 408 ? 117.808 110.040 101.612 1.00 90.24  ? 408 GLU A OE1 1 
ATOM   2911 O  OE2 . GLU A 1 408 ? 117.304 108.661 99.982  1.00 90.24  ? 408 GLU A OE2 1 
ATOM   2912 N  N   . GLY A 1 409 ? 113.347 110.036 96.514  1.00 93.04  ? 409 GLY A N   1 
ATOM   2913 C  CA  . GLY A 1 409 ? 112.908 109.717 95.166  1.00 93.04  ? 409 GLY A CA  1 
ATOM   2914 C  C   . GLY A 1 409 ? 112.123 110.844 94.527  1.00 93.04  ? 409 GLY A C   1 
ATOM   2915 O  O   . GLY A 1 409 ? 112.318 111.159 93.352  1.00 93.04  ? 409 GLY A O   1 
ATOM   2916 N  N   . GLN A 1 410 ? 111.226 111.468 95.293  1.00 90.41  ? 410 GLN A N   1 
ATOM   2917 C  CA  . GLN A 1 410 ? 110.475 112.611 94.783  1.00 90.41  ? 410 GLN A CA  1 
ATOM   2918 C  C   . GLN A 1 410 ? 111.409 113.760 94.421  1.00 90.41  ? 410 GLN A C   1 
ATOM   2919 O  O   . GLN A 1 410 ? 111.283 114.370 93.350  1.00 90.41  ? 410 GLN A O   1 
ATOM   2920 C  CB  . GLN A 1 410 ? 109.442 113.056 95.821  1.00 90.41  ? 410 GLN A CB  1 
ATOM   2921 C  CG  . GLN A 1 410 ? 108.848 114.433 95.580  1.00 90.41  ? 410 GLN A CG  1 
ATOM   2922 C  CD  . GLN A 1 410 ? 107.994 114.905 96.741  1.00 90.41  ? 410 GLN A CD  1 
ATOM   2923 O  OE1 . GLN A 1 410 ? 107.971 114.282 97.803  1.00 90.41  ? 410 GLN A OE1 1 
ATOM   2924 N  NE2 . GLN A 1 410 ? 107.278 116.005 96.540  1.00 90.41  ? 410 GLN A NE2 1 
ATOM   2925 N  N   . ILE A 1 411 ? 112.372 114.054 95.298  1.00 97.82  ? 411 ILE A N   1 
ATOM   2926 C  CA  . ILE A 1 411 ? 113.285 115.167 95.057  1.00 97.82  ? 411 ILE A CA  1 
ATOM   2927 C  C   . ILE A 1 411 ? 114.153 114.896 93.836  1.00 97.82  ? 411 ILE A C   1 
ATOM   2928 O  O   . ILE A 1 411 ? 114.391 115.792 93.021  1.00 97.82  ? 411 ILE A O   1 
ATOM   2929 C  CB  . ILE A 1 411 ? 114.133 115.450 96.309  1.00 97.82  ? 411 ILE A CB  1 
ATOM   2930 C  CG1 . ILE A 1 411 ? 113.279 116.131 97.377  1.00 97.82  ? 411 ILE A CG1 1 
ATOM   2931 C  CG2 . ILE A 1 411 ? 115.325 116.328 95.964  1.00 97.82  ? 411 ILE A CG2 1 
ATOM   2932 C  CD1 . ILE A 1 411 ? 112.737 117.472 96.946  1.00 97.82  ? 411 ILE A CD1 1 
ATOM   2933 N  N   . THR A 1 412 ? 114.639 113.664 93.684  1.00 99.60  ? 412 THR A N   1 
ATOM   2934 C  CA  . THR A 1 412 ? 115.407 113.318 92.494  1.00 99.60  ? 412 THR A CA  1 
ATOM   2935 C  C   . THR A 1 412 ? 114.553 113.453 91.241  1.00 99.60  ? 412 THR A C   1 
ATOM   2936 O  O   . THR A 1 412 ? 114.933 114.131 90.281  1.00 99.60  ? 412 THR A O   1 
ATOM   2937 C  CB  . THR A 1 412 ? 115.950 111.896 92.624  1.00 99.60  ? 412 THR A CB  1 
ATOM   2938 O  OG1 . THR A 1 412 ? 116.657 111.765 93.862  1.00 99.60  ? 412 THR A OG1 1 
ATOM   2939 C  CG2 . THR A 1 412 ? 116.896 111.573 91.483  1.00 99.60  ? 412 THR A CG2 1 
ATOM   2940 N  N   . SER A 1 413 ? 113.365 112.846 91.244  1.00 98.27  ? 413 SER A N   1 
ATOM   2941 C  CA  . SER A 1 413 ? 112.501 112.931 90.075  1.00 98.27  ? 413 SER A CA  1 
ATOM   2942 C  C   . SER A 1 413 ? 112.242 114.383 89.698  1.00 98.27  ? 413 SER A C   1 
ATOM   2943 O  O   . SER A 1 413 ? 112.114 114.712 88.514  1.00 98.27  ? 413 SER A O   1 
ATOM   2944 C  CB  . SER A 1 413 ? 111.195 112.193 90.347  1.00 98.27  ? 413 SER A CB  1 
ATOM   2945 O  OG  . SER A 1 413 ? 111.450 110.837 90.677  1.00 98.27  ? 413 SER A OG  1 
ATOM   2946 N  N   . LEU A 1 414 ? 112.185 115.270 90.696  1.00 101.81 ? 414 LEU A N   1 
ATOM   2947 C  CA  . LEU A 1 414 ? 112.031 116.692 90.411  1.00 101.81 ? 414 LEU A CA  1 
ATOM   2948 C  C   . LEU A 1 414 ? 113.313 117.306 89.847  1.00 101.81 ? 414 LEU A C   1 
ATOM   2949 O  O   . LEU A 1 414 ? 113.256 118.104 88.905  1.00 101.81 ? 414 LEU A O   1 
ATOM   2950 C  CB  . LEU A 1 414 ? 111.592 117.432 91.674  1.00 101.81 ? 414 LEU A CB  1 
ATOM   2951 C  CG  . LEU A 1 414 ? 110.127 117.250 92.084  1.00 101.81 ? 414 LEU A CG  1 
ATOM   2952 C  CD1 . LEU A 1 414 ? 109.793 118.073 93.318  1.00 101.81 ? 414 LEU A CD1 1 
ATOM   2953 C  CD2 . LEU A 1 414 ? 109.198 117.602 90.935  1.00 101.81 ? 414 LEU A CD2 1 
ATOM   2954 N  N   . VAL A 1 415 ? 114.477 116.958 90.405  1.00 104.84 ? 415 VAL A N   1 
ATOM   2955 C  CA  . VAL A 1 415 ? 115.697 117.691 90.051  1.00 104.84 ? 415 VAL A CA  1 
ATOM   2956 C  C   . VAL A 1 415 ? 116.262 117.241 88.708  1.00 104.84 ? 415 VAL A C   1 
ATOM   2957 O  O   . VAL A 1 415 ? 116.948 118.018 88.035  1.00 104.84 ? 415 VAL A O   1 
ATOM   2958 C  CB  . VAL A 1 415 ? 116.766 117.585 91.157  1.00 104.84 ? 415 VAL A CB  1 
ATOM   2959 C  CG1 . VAL A 1 415 ? 116.258 118.189 92.458  1.00 104.84 ? 415 VAL A CG1 1 
ATOM   2960 C  CG2 . VAL A 1 415 ? 117.223 116.148 91.347  1.00 104.84 ? 415 VAL A CG2 1 
ATOM   2961 N  N   . ASP A 1 416 ? 116.002 115.999 88.293  1.00 104.50 ? 416 ASP A N   1 
ATOM   2962 C  CA  . ASP A 1 416 ? 116.331 115.621 86.918  1.00 104.50 ? 416 ASP A CA  1 
ATOM   2963 C  C   . ASP A 1 416 ? 115.565 116.443 85.888  1.00 104.50 ? 416 ASP A C   1 
ATOM   2964 O  O   . ASP A 1 416 ? 115.976 116.485 84.723  1.00 104.50 ? 416 ASP A O   1 
ATOM   2965 C  CB  . ASP A 1 416 ? 116.090 114.131 86.655  1.00 104.50 ? 416 ASP A CB  1 
ATOM   2966 C  CG  . ASP A 1 416 ? 116.880 113.231 87.583  1.00 104.50 ? 416 ASP A CG  1 
ATOM   2967 O  OD1 . ASP A 1 416 ? 116.608 113.198 88.786  1.00 104.50 ? 416 ASP A OD1 1 
ATOM   2968 O  OD2 . ASP A 1 416 ? 117.791 112.532 87.088  1.00 104.50 ? 416 ASP A OD2 1 
ATOM   2969 N  N   . LEU A 1 417 ? 114.461 117.085 86.278  1.00 107.76 ? 417 LEU A N   1 
ATOM   2970 C  CA  . LEU A 1 417 ? 113.770 117.976 85.353  1.00 107.76 ? 417 LEU A CA  1 
ATOM   2971 C  C   . LEU A 1 417 ? 114.540 119.276 85.156  1.00 107.76 ? 417 LEU A C   1 
ATOM   2972 O  O   . LEU A 1 417 ? 114.666 119.760 84.026  1.00 107.76 ? 417 LEU A O   1 
ATOM   2973 C  CB  . LEU A 1 417 ? 112.352 118.264 85.848  1.00 107.76 ? 417 LEU A CB  1 
ATOM   2974 C  CG  . LEU A 1 417 ? 111.369 117.092 85.885  1.00 107.76 ? 417 LEU A CG  1 
ATOM   2975 C  CD1 . LEU A 1 417 ? 110.173 117.406 86.773  1.00 107.76 ? 417 LEU A CD1 1 
ATOM   2976 C  CD2 . LEU A 1 417 ? 110.920 116.745 84.479  1.00 107.76 ? 417 LEU A CD2 1 
ATOM   2977 N  N   . TYR A 1 418 ? 115.055 119.856 86.237  1.00 115.69 ? 418 TYR A N   1 
ATOM   2978 C  CA  . TYR A 1 418 ? 115.809 121.109 86.181  1.00 115.69 ? 418 TYR A CA  1 
ATOM   2979 C  C   . TYR A 1 418 ? 117.130 120.947 86.919  1.00 115.69 ? 418 TYR A C   1 
ATOM   2980 O  O   . TYR A 1 418 ? 117.207 121.237 88.125  1.00 115.69 ? 418 TYR A O   1 
ATOM   2981 C  CB  . TYR A 1 418 ? 115.003 122.259 86.784  1.00 115.69 ? 418 TYR A CB  1 
ATOM   2982 C  CG  . TYR A 1 418 ? 113.726 122.575 86.045  1.00 115.69 ? 418 TYR A CG  1 
ATOM   2983 C  CD1 . TYR A 1 418 ? 113.735 123.405 84.934  1.00 115.69 ? 418 TYR A CD1 1 
ATOM   2984 C  CD2 . TYR A 1 418 ? 112.510 122.049 86.461  1.00 115.69 ? 418 TYR A CD2 1 
ATOM   2985 C  CE1 . TYR A 1 418 ? 112.571 123.700 84.255  1.00 115.69 ? 418 TYR A CE1 1 
ATOM   2986 C  CE2 . TYR A 1 418 ? 111.340 122.339 85.788  1.00 115.69 ? 418 TYR A CE2 1 
ATOM   2987 C  CZ  . TYR A 1 418 ? 111.378 123.165 84.685  1.00 115.69 ? 418 TYR A CZ  1 
ATOM   2988 O  OH  . TYR A 1 418 ? 110.220 123.461 84.006  1.00 115.69 ? 418 TYR A OH  1 
ATOM   2989 N  N   . PRO A 1 419 ? 118.190 120.488 86.255  1.00 117.03 ? 419 PRO A N   1 
ATOM   2990 C  CA  . PRO A 1 419 ? 119.469 120.310 86.955  1.00 117.03 ? 419 PRO A CA  1 
ATOM   2991 C  C   . PRO A 1 419 ? 120.173 121.626 87.255  1.00 117.03 ? 419 PRO A C   1 
ATOM   2992 O  O   . PRO A 1 419 ? 120.670 121.834 88.368  1.00 117.03 ? 419 PRO A O   1 
ATOM   2993 C  CB  . PRO A 1 419 ? 120.280 119.447 85.981  1.00 117.03 ? 419 PRO A CB  1 
ATOM   2994 C  CG  . PRO A 1 419 ? 119.720 119.768 84.637  1.00 117.03 ? 419 PRO A CG  1 
ATOM   2995 C  CD  . PRO A 1 419 ? 118.268 120.116 84.831  1.00 117.03 ? 419 PRO A CD  1 
ATOM   2996 N  N   . SER A 1 420 ? 120.206 122.528 86.271  1.00 120.51 ? 420 SER A N   1 
ATOM   2997 C  CA  . SER A 1 420 ? 120.928 123.785 86.439  1.00 120.51 ? 420 SER A CA  1 
ATOM   2998 C  C   . SER A 1 420 ? 120.304 124.638 87.536  1.00 120.51 ? 420 SER A C   1 
ATOM   2999 O  O   . SER A 1 420 ? 121.012 125.188 88.386  1.00 120.51 ? 420 SER A O   1 
ATOM   3000 C  CB  . SER A 1 420 ? 120.961 124.551 85.117  1.00 120.51 ? 420 SER A CB  1 
ATOM   3001 O  OG  . SER A 1 420 ? 119.655 124.920 84.711  1.00 120.51 ? 420 SER A OG  1 
ATOM   3002 N  N   . PHE A 1 421 ? 118.975 124.761 87.533  1.00 118.84 ? 421 PHE A N   1 
ATOM   3003 C  CA  . PHE A 1 421 ? 118.311 125.548 88.565  1.00 118.84 ? 421 PHE A CA  1 
ATOM   3004 C  C   . PHE A 1 421 ? 118.378 124.845 89.916  1.00 118.84 ? 421 PHE A C   1 
ATOM   3005 O  O   . PHE A 1 421 ? 118.721 125.459 90.932  1.00 118.84 ? 421 PHE A O   1 
ATOM   3006 C  CB  . PHE A 1 421 ? 116.861 125.822 88.167  1.00 118.84 ? 421 PHE A CB  1 
ATOM   3007 C  CG  . PHE A 1 421 ? 115.975 126.181 89.325  1.00 118.84 ? 421 PHE A CG  1 
ATOM   3008 C  CD1 . PHE A 1 421 ? 116.136 127.385 89.989  1.00 118.84 ? 421 PHE A CD1 1 
ATOM   3009 C  CD2 . PHE A 1 421 ? 114.985 125.313 89.753  1.00 118.84 ? 421 PHE A CD2 1 
ATOM   3010 C  CE1 . PHE A 1 421 ? 115.325 127.720 91.053  1.00 118.84 ? 421 PHE A CE1 1 
ATOM   3011 C  CE2 . PHE A 1 421 ? 114.172 125.641 90.819  1.00 118.84 ? 421 PHE A CE2 1 
ATOM   3012 C  CZ  . PHE A 1 421 ? 114.342 126.847 91.470  1.00 118.84 ? 421 PHE A CZ  1 
ATOM   3013 N  N   . LEU A 1 422 ? 118.053 123.553 89.948  1.00 117.10 ? 422 LEU A N   1 
ATOM   3014 C  CA  . LEU A 1 422 ? 118.100 122.780 91.188  1.00 117.10 ? 422 LEU A CA  1 
ATOM   3015 C  C   . LEU A 1 422 ? 119.458 122.088 91.314  1.00 117.10 ? 422 LEU A C   1 
ATOM   3016 O  O   . LEU A 1 422 ? 119.570 120.895 91.601  1.00 117.10 ? 422 LEU A O   1 
ATOM   3017 C  CB  . LEU A 1 422 ? 116.953 121.774 91.228  1.00 117.10 ? 422 LEU A CB  1 
ATOM   3018 C  CG  . LEU A 1 422 ? 115.623 122.234 91.824  1.00 117.10 ? 422 LEU A CG  1 
ATOM   3019 C  CD1 . LEU A 1 422 ? 114.485 121.368 91.305  1.00 117.10 ? 422 LEU A CD1 1 
ATOM   3020 C  CD2 . LEU A 1 422 ? 115.673 122.206 93.341  1.00 117.10 ? 422 LEU A CD2 1 
ATOM   3021 N  N   . ARG A 1 423 ? 120.502 122.879 91.097  1.00 122.63 ? 423 ARG A N   1 
ATOM   3022 C  CA  . ARG A 1 423 ? 121.874 122.456 91.337  1.00 122.63 ? 423 ARG A CA  1 
ATOM   3023 C  C   . ARG A 1 423 ? 122.105 122.262 92.829  1.00 122.63 ? 423 ARG A C   1 
ATOM   3024 O  O   . ARG A 1 423 ? 121.415 122.861 93.658  1.00 122.63 ? 423 ARG A O   1 
ATOM   3025 C  CB  . ARG A 1 423 ? 122.849 123.495 90.782  1.00 122.63 ? 423 ARG A CB  1 
ATOM   3026 C  CG  . ARG A 1 423 ? 122.821 124.816 91.536  1.00 122.63 ? 423 ARG A CG  1 
ATOM   3027 C  CD  . ARG A 1 423 ? 123.782 125.835 90.946  1.00 122.63 ? 423 ARG A CD  1 
ATOM   3028 N  NE  . ARG A 1 423 ? 123.320 126.330 89.655  1.00 122.63 ? 423 ARG A NE  1 
ATOM   3029 C  CZ  . ARG A 1 423 ? 124.016 127.141 88.869  1.00 122.63 ? 423 ARG A CZ  1 
ATOM   3030 N  NH1 . ARG A 1 423 ? 125.221 127.569 89.210  1.00 122.63 ? 423 ARG A NH1 1 
ATOM   3031 N  NH2 . ARG A 1 423 ? 123.488 127.536 87.714  1.00 122.63 ? 423 ARG A NH2 1 
ATOM   3032 N  N   . LYS A 1 424 ? 123.071 121.410 93.167  1.00 122.12 ? 424 LYS A N   1 
ATOM   3033 C  CA  . LYS A 1 424 ? 123.416 121.194 94.566  1.00 122.12 ? 424 LYS A CA  1 
ATOM   3034 C  C   . LYS A 1 424 ? 123.950 122.479 95.185  1.00 122.12 ? 424 LYS A C   1 
ATOM   3035 O  O   . LYS A 1 424 ? 124.784 123.170 94.595  1.00 122.12 ? 424 LYS A O   1 
ATOM   3036 C  CB  . LYS A 1 424 ? 124.447 120.070 94.690  1.00 122.12 ? 424 LYS A CB  1 
ATOM   3037 C  CG  . LYS A 1 424 ? 123.888 118.686 94.398  1.00 122.12 ? 424 LYS A CG  1 
ATOM   3038 C  CD  . LYS A 1 424 ? 124.968 117.619 94.461  1.00 122.12 ? 424 LYS A CD  1 
ATOM   3039 C  CE  . LYS A 1 424 ? 125.411 117.366 95.894  1.00 122.12 ? 424 LYS A CE  1 
ATOM   3040 N  NZ  . LYS A 1 424 ? 124.352 116.707 96.705  1.00 122.12 ? 424 LYS A NZ  1 
ATOM   3041 N  N   . GLY A 1 425 ? 123.460 122.795 96.369  1.00 117.17 ? 425 GLY A N   1 
ATOM   3042 C  CA  . GLY A 1 425 ? 123.814 124.026 97.046  1.00 117.17 ? 425 GLY A CA  1 
ATOM   3043 C  C   . GLY A 1 425 ? 122.667 124.490 97.929  1.00 117.17 ? 425 GLY A C   1 
ATOM   3044 O  O   . GLY A 1 425 ? 121.920 123.677 98.470  1.00 117.17 ? 425 GLY A O   1 
ATOM   3045 N  N   . TYR A 1 426 ? 122.556 125.814 98.066  1.00 116.21 ? 426 TYR A N   1 
ATOM   3046 C  CA  . TYR A 1 426 ? 121.517 126.385 98.917  1.00 116.21 ? 426 TYR A CA  1 
ATOM   3047 C  C   . TYR A 1 426 ? 120.136 126.226 98.293  1.00 116.21 ? 426 TYR A C   1 
ATOM   3048 O  O   . TYR A 1 426 ? 119.146 126.029 99.007  1.00 116.21 ? 426 TYR A O   1 
ATOM   3049 C  CB  . TYR A 1 426 ? 121.807 127.860 99.203  1.00 116.21 ? 426 TYR A CB  1 
ATOM   3050 C  CG  . TYR A 1 426 ? 122.079 128.708 97.979  1.00 116.21 ? 426 TYR A CG  1 
ATOM   3051 C  CD1 . TYR A 1 426 ? 123.287 128.626 97.296  1.00 116.21 ? 426 TYR A CD1 1 
ATOM   3052 C  CD2 . TYR A 1 426 ? 121.121 129.591 97.504  1.00 116.21 ? 426 TYR A CD2 1 
ATOM   3053 C  CE1 . TYR A 1 426 ? 123.530 129.401 96.178  1.00 116.21 ? 426 TYR A CE1 1 
ATOM   3054 C  CE2 . TYR A 1 426 ? 121.354 130.369 96.389  1.00 116.21 ? 426 TYR A CE2 1 
ATOM   3055 C  CZ  . TYR A 1 426 ? 122.559 130.271 95.731  1.00 116.21 ? 426 TYR A CZ  1 
ATOM   3056 O  OH  . TYR A 1 426 ? 122.788 131.047 94.620  1.00 116.21 ? 426 TYR A OH  1 
ATOM   3057 N  N   . ARG A 1 427 ? 120.048 126.313 96.963  1.00 116.75 ? 427 ARG A N   1 
ATOM   3058 C  CA  . ARG A 1 427 ? 118.751 126.230 96.298  1.00 116.75 ? 427 ARG A CA  1 
ATOM   3059 C  C   . ARG A 1 427 ? 118.060 124.900 96.569  1.00 116.75 ? 427 ARG A C   1 
ATOM   3060 O  O   . ARG A 1 427 ? 116.870 124.874 96.907  1.00 116.75 ? 427 ARG A O   1 
ATOM   3061 C  CB  . ARG A 1 427 ? 118.925 126.434 94.794  1.00 116.75 ? 427 ARG A CB  1 
ATOM   3062 C  CG  . ARG A 1 427 ? 119.423 127.810 94.401  1.00 116.75 ? 427 ARG A CG  1 
ATOM   3063 C  CD  . ARG A 1 427 ? 119.633 127.888 92.901  1.00 116.75 ? 427 ARG A CD  1 
ATOM   3064 N  NE  . ARG A 1 427 ? 120.167 129.178 92.486  1.00 116.75 ? 427 ARG A NE  1 
ATOM   3065 C  CZ  . ARG A 1 427 ? 120.528 129.475 91.245  1.00 116.75 ? 427 ARG A CZ  1 
ATOM   3066 N  NH1 . ARG A 1 427 ? 120.441 128.586 90.268  1.00 116.75 ? 427 ARG A NH1 1 
ATOM   3067 N  NH2 . ARG A 1 427 ? 120.989 130.693 90.977  1.00 116.75 ? 427 ARG A NH2 1 
ATOM   3068 N  N   . ARG A 1 428 ? 118.786 123.792 96.443  1.00 111.95 ? 428 ARG A N   1 
ATOM   3069 C  CA  . ARG A 1 428 ? 118.231 122.478 96.735  1.00 111.95 ? 428 ARG A CA  1 
ATOM   3070 C  C   . ARG A 1 428 ? 117.832 122.324 98.194  1.00 111.95 ? 428 ARG A C   1 
ATOM   3071 O  O   . ARG A 1 428 ? 116.915 121.553 98.496  1.00 111.95 ? 428 ARG A O   1 
ATOM   3072 C  CB  . ARG A 1 428 ? 119.242 121.389 96.358  1.00 111.95 ? 428 ARG A CB  1 
ATOM   3073 C  CG  . ARG A 1 428 ? 118.710 119.970 96.454  1.00 111.95 ? 428 ARG A CG  1 
ATOM   3074 C  CD  . ARG A 1 428 ? 119.715 118.974 95.906  1.00 111.95 ? 428 ARG A CD  1 
ATOM   3075 N  NE  . ARG A 1 428 ? 119.290 117.594 96.098  1.00 111.95 ? 428 ARG A NE  1 
ATOM   3076 C  CZ  . ARG A 1 428 ? 119.978 116.540 95.681  1.00 111.95 ? 428 ARG A CZ  1 
ATOM   3077 N  NH1 . ARG A 1 428 ? 121.107 116.675 95.006  1.00 111.95 ? 428 ARG A NH1 1 
ATOM   3078 N  NH2 . ARG A 1 428 ? 119.517 115.319 95.941  1.00 111.95 ? 428 ARG A NH2 1 
ATOM   3079 N  N   . GLU A 1 429 ? 118.498 123.046 99.092  1.00 109.12 ? 429 GLU A N   1 
ATOM   3080 C  CA  . GLU A 1 429 ? 118.182 122.984 100.513 1.00 109.12 ? 429 GLU A CA  1 
ATOM   3081 C  C   . GLU A 1 429 ? 116.894 123.739 100.833 1.00 109.12 ? 429 GLU A C   1 
ATOM   3082 O  O   . GLU A 1 429 ? 116.027 123.238 101.564 1.00 109.12 ? 429 GLU A O   1 
ATOM   3083 C  CB  . GLU A 1 429 ? 119.361 123.551 101.297 1.00 109.12 ? 429 GLU A CB  1 
ATOM   3084 C  CG  . GLU A 1 429 ? 119.242 123.498 102.793 1.00 109.12 ? 429 GLU A CG  1 
ATOM   3085 C  CD  . GLU A 1 429 ? 120.484 124.040 103.455 1.00 109.12 ? 429 GLU A CD  1 
ATOM   3086 O  OE1 . GLU A 1 429 ? 121.403 124.468 102.732 1.00 109.12 ? 429 GLU A OE1 1 
ATOM   3087 O  OE2 . GLU A 1 429 ? 120.549 124.023 104.702 1.00 109.12 ? 429 GLU A OE2 1 
ATOM   3088 N  N   . ILE A 1 430 ? 116.746 124.949 100.286 1.00 103.25 ? 430 ILE A N   1 
ATOM   3089 C  CA  . ILE A 1 430 ? 115.519 125.708 100.503 1.00 103.25 ? 430 ILE A CA  1 
ATOM   3090 C  C   . ILE A 1 430 ? 114.352 125.035 99.795  1.00 103.25 ? 430 ILE A C   1 
ATOM   3091 O  O   . ILE A 1 430 ? 113.198 125.165 100.214 1.00 103.25 ? 430 ILE A O   1 
ATOM   3092 C  CB  . ILE A 1 430 ? 115.695 127.174 100.059 1.00 103.25 ? 430 ILE A CB  1 
ATOM   3093 C  CG1 . ILE A 1 430 ? 115.882 127.277 98.549  1.00 103.25 ? 430 ILE A CG1 1 
ATOM   3094 C  CG2 . ILE A 1 430 ? 116.870 127.813 100.778 1.00 103.25 ? 430 ILE A CG2 1 
ATOM   3095 C  CD1 . ILE A 1 430 ? 115.792 128.688 98.016  1.00 103.25 ? 430 ILE A CD1 1 
ATOM   3096 N  N   . PHE A 1 431 ? 114.632 124.295 98.717  1.00 100.99 ? 431 PHE A N   1 
ATOM   3097 C  CA  . PHE A 1 431 ? 113.592 123.494 98.077  1.00 100.99 ? 431 PHE A CA  1 
ATOM   3098 C  C   . PHE A 1 431 ? 113.017 122.468 99.048  1.00 100.99 ? 431 PHE A C   1 
ATOM   3099 O  O   . PHE A 1 431 ? 111.793 122.341 99.187  1.00 100.99 ? 431 PHE A O   1 
ATOM   3100 C  CB  . PHE A 1 431 ? 114.166 122.805 96.839  1.00 100.99 ? 431 PHE A CB  1 
ATOM   3101 C  CG  . PHE A 1 431 ? 113.126 122.278 95.898  1.00 100.99 ? 431 PHE A CG  1 
ATOM   3102 C  CD1 . PHE A 1 431 ? 112.447 123.132 95.050  1.00 100.99 ? 431 PHE A CD1 1 
ATOM   3103 C  CD2 . PHE A 1 431 ? 112.836 120.926 95.854  1.00 100.99 ? 431 PHE A CD2 1 
ATOM   3104 C  CE1 . PHE A 1 431 ? 111.493 122.649 94.180  1.00 100.99 ? 431 PHE A CE1 1 
ATOM   3105 C  CE2 . PHE A 1 431 ? 111.882 120.438 94.985  1.00 100.99 ? 431 PHE A CE2 1 
ATOM   3106 C  CZ  . PHE A 1 431 ? 111.211 121.301 94.148  1.00 100.99 ? 431 PHE A CZ  1 
ATOM   3107 N  N   . ILE A 1 432 ? 113.893 121.732 99.739  1.00 95.52  ? 432 ILE A N   1 
ATOM   3108 C  CA  . ILE A 1 432 ? 113.439 120.748 100.719 1.00 95.52  ? 432 ILE A CA  1 
ATOM   3109 C  C   . ILE A 1 432 ? 112.694 121.437 101.853 1.00 95.52  ? 432 ILE A C   1 
ATOM   3110 O  O   . ILE A 1 432 ? 111.672 120.940 102.342 1.00 95.52  ? 432 ILE A O   1 
ATOM   3111 C  CB  . ILE A 1 432 ? 114.625 119.920 101.248 1.00 95.52  ? 432 ILE A CB  1 
ATOM   3112 C  CG1 . ILE A 1 432 ? 115.359 119.233 100.097 1.00 95.52  ? 432 ILE A CG1 1 
ATOM   3113 C  CG2 . ILE A 1 432 ? 114.149 118.884 102.256 1.00 95.52  ? 432 ILE A CG2 1 
ATOM   3114 C  CD1 . ILE A 1 432 ? 116.766 118.802 100.443 1.00 95.52  ? 432 ILE A CD1 1 
ATOM   3115 N  N   . ALA A 1 433 ? 113.198 122.593 102.291 1.00 91.42  ? 433 ALA A N   1 
ATOM   3116 C  CA  . ALA A 1 433 ? 112.520 123.332 103.354 1.00 91.42  ? 433 ALA A CA  1 
ATOM   3117 C  C   . ALA A 1 433 ? 111.098 123.712 102.947 1.00 91.42  ? 433 ALA A C   1 
ATOM   3118 O  O   . ALA A 1 433 ? 110.144 123.518 103.711 1.00 91.42  ? 433 ALA A O   1 
ATOM   3119 C  CB  . ALA A 1 433 ? 113.325 124.578 103.721 1.00 91.42  ? 433 ALA A CB  1 
ATOM   3120 N  N   . PHE A 1 434 ? 110.939 124.250 101.734 1.00 86.94  ? 434 PHE A N   1 
ATOM   3121 C  CA  . PHE A 1 434 ? 109.622 124.660 101.256 1.00 86.94  ? 434 PHE A CA  1 
ATOM   3122 C  C   . PHE A 1 434 ? 108.685 123.466 101.137 1.00 86.94  ? 434 PHE A C   1 
ATOM   3123 O  O   . PHE A 1 434 ? 107.512 123.541 101.527 1.00 86.94  ? 434 PHE A O   1 
ATOM   3124 C  CB  . PHE A 1 434 ? 109.764 125.388 99.914  1.00 86.94  ? 434 PHE A CB  1 
ATOM   3125 C  CG  . PHE A 1 434 ? 108.459 125.877 99.330  1.00 86.94  ? 434 PHE A CG  1 
ATOM   3126 C  CD1 . PHE A 1 434 ? 107.623 125.022 98.627  1.00 86.94  ? 434 PHE A CD1 1 
ATOM   3127 C  CD2 . PHE A 1 434 ? 108.072 127.198 99.485  1.00 86.94  ? 434 PHE A CD2 1 
ATOM   3128 C  CE1 . PHE A 1 434 ? 106.431 125.474 98.092  1.00 86.94  ? 434 PHE A CE1 1 
ATOM   3129 C  CE2 . PHE A 1 434 ? 106.879 127.655 98.953  1.00 86.94  ? 434 PHE A CE2 1 
ATOM   3130 C  CZ  . PHE A 1 434 ? 106.058 126.792 98.257  1.00 86.94  ? 434 PHE A CZ  1 
ATOM   3131 N  N   . VAL A 1 435 ? 109.184 122.353 100.593 1.00 82.42  ? 435 VAL A N   1 
ATOM   3132 C  CA  . VAL A 1 435 ? 108.339 121.173 100.433 1.00 82.42  ? 435 VAL A CA  1 
ATOM   3133 C  C   . VAL A 1 435 ? 107.884 120.657 101.792 1.00 82.42  ? 435 VAL A C   1 
ATOM   3134 O  O   . VAL A 1 435 ? 106.707 120.326 101.985 1.00 82.42  ? 435 VAL A O   1 
ATOM   3135 C  CB  . VAL A 1 435 ? 109.078 120.088 99.628  1.00 82.42  ? 435 VAL A CB  1 
ATOM   3136 C  CG1 . VAL A 1 435 ? 108.345 118.763 99.719  1.00 82.42  ? 435 VAL A CG1 1 
ATOM   3137 C  CG2 . VAL A 1 435 ? 109.223 120.516 98.178  1.00 82.42  ? 435 VAL A CG2 1 
ATOM   3138 N  N   . CYS A 1 436 ? 108.803 120.599 102.760 1.00 81.70  ? 436 CYS A N   1 
ATOM   3139 C  CA  . CYS A 1 436 ? 108.442 120.135 104.096 1.00 81.70  ? 436 CYS A CA  1 
ATOM   3140 C  C   . CYS A 1 436 ? 107.412 121.052 104.743 1.00 81.70  ? 436 CYS A C   1 
ATOM   3141 O  O   . CYS A 1 436 ? 106.447 120.580 105.357 1.00 81.70  ? 436 CYS A O   1 
ATOM   3142 C  CB  . CYS A 1 436 ? 109.693 120.035 104.969 1.00 81.70  ? 436 CYS A CB  1 
ATOM   3143 S  SG  . CYS A 1 436 ? 110.819 118.691 104.530 1.00 81.70  ? 436 CYS A SG  1 
ATOM   3144 N  N   . SER A 1 437 ? 107.598 122.370 104.617 1.00 78.32  ? 437 SER A N   1 
ATOM   3145 C  CA  . SER A 1 437 ? 106.659 123.306 105.227 1.00 78.32  ? 437 SER A CA  1 
ATOM   3146 C  C   . SER A 1 437 ? 105.269 123.182 104.615 1.00 78.32  ? 437 SER A C   1 
ATOM   3147 O  O   . SER A 1 437 ? 104.266 123.150 105.339 1.00 78.32  ? 437 SER A O   1 
ATOM   3148 C  CB  . SER A 1 437 ? 107.183 124.734 105.089 1.00 78.32  ? 437 SER A CB  1 
ATOM   3149 O  OG  . SER A 1 437 ? 108.466 124.859 105.673 1.00 78.32  ? 437 SER A OG  1 
ATOM   3150 N  N   . ILE A 1 438 ? 105.188 123.101 103.285 1.00 76.91  ? 438 ILE A N   1 
ATOM   3151 C  CA  . ILE A 1 438 ? 103.887 122.994 102.633 1.00 76.91  ? 438 ILE A CA  1 
ATOM   3152 C  C   . ILE A 1 438 ? 103.212 121.675 102.989 1.00 76.91  ? 438 ILE A C   1 
ATOM   3153 O  O   . ILE A 1 438 ? 101.996 121.628 103.220 1.00 76.91  ? 438 ILE A O   1 
ATOM   3154 C  CB  . ILE A 1 438 ? 104.034 123.171 101.112 1.00 76.91  ? 438 ILE A CB  1 
ATOM   3155 C  CG1 . ILE A 1 438 ? 104.389 124.621 100.787 1.00 76.91  ? 438 ILE A CG1 1 
ATOM   3156 C  CG2 . ILE A 1 438 ? 102.756 122.780 100.398 1.00 76.91  ? 438 ILE A CG2 1 
ATOM   3157 C  CD1 . ILE A 1 438 ? 103.376 125.620 101.293 1.00 76.91  ? 438 ILE A CD1 1 
ATOM   3158 N  N   . SER A 1 439 ? 103.980 120.583 103.041 1.00 71.22  ? 439 SER A N   1 
ATOM   3159 C  CA  . SER A 1 439 ? 103.397 119.299 103.409 1.00 71.22  ? 439 SER A CA  1 
ATOM   3160 C  C   . SER A 1 439 ? 102.885 119.314 104.843 1.00 71.22  ? 439 SER A C   1 
ATOM   3161 O  O   . SER A 1 439 ? 101.828 118.745 105.133 1.00 71.22  ? 439 SER A O   1 
ATOM   3162 C  CB  . SER A 1 439 ? 104.417 118.183 103.209 1.00 71.22  ? 439 SER A CB  1 
ATOM   3163 O  OG  . SER A 1 439 ? 104.930 118.199 101.890 1.00 71.22  ? 439 SER A OG  1 
ATOM   3164 N  N   . TYR A 1 440 ? 103.617 119.960 105.754 1.00 69.65  ? 440 TYR A N   1 
ATOM   3165 C  CA  . TYR A 1 440 ? 103.145 120.091 107.130 1.00 69.65  ? 440 TYR A CA  1 
ATOM   3166 C  C   . TYR A 1 440 ? 101.849 120.894 107.191 1.00 69.65  ? 440 TYR A C   1 
ATOM   3167 O  O   . TYR A 1 440 ? 100.894 120.516 107.888 1.00 69.65  ? 440 TYR A O   1 
ATOM   3168 C  CB  . TYR A 1 440 ? 104.232 120.746 107.984 1.00 69.65  ? 440 TYR A CB  1 
ATOM   3169 C  CG  . TYR A 1 440 ? 103.812 121.059 109.399 1.00 69.65  ? 440 TYR A CG  1 
ATOM   3170 C  CD1 . TYR A 1 440 ? 103.660 120.050 110.334 1.00 69.65  ? 440 TYR A CD1 1 
ATOM   3171 C  CD2 . TYR A 1 440 ? 103.573 122.364 109.801 1.00 69.65  ? 440 TYR A CD2 1 
ATOM   3172 C  CE1 . TYR A 1 440 ? 103.280 120.328 111.627 1.00 69.65  ? 440 TYR A CE1 1 
ATOM   3173 C  CE2 . TYR A 1 440 ? 103.191 122.652 111.093 1.00 69.65  ? 440 TYR A CE2 1 
ATOM   3174 C  CZ  . TYR A 1 440 ? 103.046 121.629 112.001 1.00 69.65  ? 440 TYR A CZ  1 
ATOM   3175 O  OH  . TYR A 1 440 ? 102.665 121.903 113.292 1.00 69.65  ? 440 TYR A OH  1 
ATOM   3176 N  N   . LEU A 1 441 ? 101.792 122.002 106.448 1.00 67.17  ? 441 LEU A N   1 
ATOM   3177 C  CA  . LEU A 1 441 ? 100.587 122.823 106.445 1.00 67.17  ? 441 LEU A CA  1 
ATOM   3178 C  C   . LEU A 1 441 ? 99.389  122.042 105.922 1.00 67.17  ? 441 LEU A C   1 
ATOM   3179 O  O   . LEU A 1 441 ? 98.298  122.110 106.500 1.00 67.17  ? 441 LEU A O   1 
ATOM   3180 C  CB  . LEU A 1 441 ? 100.807 124.084 105.612 1.00 67.17  ? 441 LEU A CB  1 
ATOM   3181 C  CG  . LEU A 1 441 ? 101.652 125.186 106.253 1.00 67.17  ? 441 LEU A CG  1 
ATOM   3182 C  CD1 . LEU A 1 441 ? 101.468 126.494 105.510 1.00 67.17  ? 441 LEU A CD1 1 
ATOM   3183 C  CD2 . LEU A 1 441 ? 101.304 125.351 107.720 1.00 67.17  ? 441 LEU A CD2 1 
ATOM   3184 N  N   . LEU A 1 442 ? 99.570  121.287 104.836 1.00 65.08  ? 442 LEU A N   1 
ATOM   3185 C  CA  . LEU A 1 442 ? 98.454  120.508 104.305 1.00 65.08  ? 442 LEU A CA  1 
ATOM   3186 C  C   . LEU A 1 442 ? 98.050  119.389 105.257 1.00 65.08  ? 442 LEU A C   1 
ATOM   3187 O  O   . LEU A 1 442 ? 96.856  119.141 105.456 1.00 65.08  ? 442 LEU A O   1 
ATOM   3188 C  CB  . LEU A 1 442 ? 98.793  119.936 102.932 1.00 65.08  ? 442 LEU A CB  1 
ATOM   3189 C  CG  . LEU A 1 442 ? 97.603  119.176 102.342 1.00 65.08  ? 442 LEU A CG  1 
ATOM   3190 C  CD1 . LEU A 1 442 ? 96.430  120.118 102.129 1.00 65.08  ? 442 LEU A CD1 1 
ATOM   3191 C  CD2 . LEU A 1 442 ? 97.960  118.467 101.050 1.00 65.08  ? 442 LEU A CD2 1 
ATOM   3192 N  N   . GLY A 1 443 ? 99.023  118.708 105.862 1.00 63.66  ? 443 GLY A N   1 
ATOM   3193 C  CA  . GLY A 1 443 ? 98.713  117.642 106.794 1.00 63.66  ? 443 GLY A CA  1 
ATOM   3194 C  C   . GLY A 1 443 ? 98.121  118.111 108.102 1.00 63.66  ? 443 GLY A C   1 
ATOM   3195 O  O   . GLY A 1 443 ? 97.653  117.276 108.882 1.00 63.66  ? 443 GLY A O   1 
ATOM   3196 N  N   . LEU A 1 444 ? 98.150  119.420 108.367 1.00 67.12  ? 444 LEU A N   1 
ATOM   3197 C  CA  . LEU A 1 444 ? 97.464  119.946 109.547 1.00 67.12  ? 444 LEU A CA  1 
ATOM   3198 C  C   . LEU A 1 444 ? 95.969  119.634 109.538 1.00 67.12  ? 444 LEU A C   1 
ATOM   3199 O  O   . LEU A 1 444 ? 95.342  119.594 110.602 1.00 67.12  ? 444 LEU A O   1 
ATOM   3200 C  CB  . LEU A 1 444 ? 97.673  121.456 109.650 1.00 67.12  ? 444 LEU A CB  1 
ATOM   3201 C  CG  . LEU A 1 444 ? 98.860  121.956 110.473 1.00 67.12  ? 444 LEU A CG  1 
ATOM   3202 C  CD1 . LEU A 1 444 ? 98.936  123.473 110.414 1.00 67.12  ? 444 LEU A CD1 1 
ATOM   3203 C  CD2 . LEU A 1 444 ? 98.776  121.472 111.910 1.00 67.12  ? 444 LEU A CD2 1 
ATOM   3204 N  N   . THR A 1 445 ? 95.374  119.419 108.360 1.00 63.33  ? 445 THR A N   1 
ATOM   3205 C  CA  . THR A 1 445 ? 93.936  119.169 108.288 1.00 63.33  ? 445 THR A CA  1 
ATOM   3206 C  C   . THR A 1 445 ? 93.540  117.811 108.852 1.00 63.33  ? 445 THR A C   1 
ATOM   3207 O  O   . THR A 1 445 ? 92.348  117.572 109.069 1.00 63.33  ? 445 THR A O   1 
ATOM   3208 C  CB  . THR A 1 445 ? 93.441  119.274 106.844 1.00 63.33  ? 445 THR A CB  1 
ATOM   3209 O  OG1 . THR A 1 445 ? 94.112  118.302 106.035 1.00 63.33  ? 445 THR A OG1 1 
ATOM   3210 C  CG2 . THR A 1 445 ? 93.704  120.659 106.286 1.00 63.33  ? 445 THR A CG2 1 
ATOM   3211 N  N   . MET A 1 446 ? 94.497  116.915 109.081 1.00 62.95  ? 446 MET A N   1 
ATOM   3212 C  CA  . MET A 1 446 ? 94.211  115.580 109.585 1.00 62.95  ? 446 MET A CA  1 
ATOM   3213 C  C   . MET A 1 446 ? 94.394  115.459 111.091 1.00 62.95  ? 446 MET A C   1 
ATOM   3214 O  O   . MET A 1 446 ? 94.132  114.389 111.647 1.00 62.95  ? 446 MET A O   1 
ATOM   3215 C  CB  . MET A 1 446 ? 95.099  114.552 108.880 1.00 62.95  ? 446 MET A CB  1 
ATOM   3216 C  CG  . MET A 1 446 ? 94.595  114.119 107.519 1.00 62.95  ? 446 MET A CG  1 
ATOM   3217 S  SD  . MET A 1 446 ? 95.930  113.495 106.484 1.00 62.95  ? 446 MET A SD  1 
ATOM   3218 C  CE  . MET A 1 446 ? 95.619  114.375 104.963 1.00 62.95  ? 446 MET A CE  1 
ATOM   3219 N  N   . VAL A 1 447 ? 94.853  116.517 111.765 1.00 66.81  ? 447 VAL A N   1 
ATOM   3220 C  CA  . VAL A 1 447 ? 95.033  116.487 113.212 1.00 66.81  ? 447 VAL A CA  1 
ATOM   3221 C  C   . VAL A 1 447 ? 93.956  117.267 113.950 1.00 66.81  ? 447 VAL A C   1 
ATOM   3222 O  O   . VAL A 1 447 ? 94.044  117.418 115.177 1.00 66.81  ? 447 VAL A O   1 
ATOM   3223 C  CB  . VAL A 1 447 ? 96.432  116.996 113.617 1.00 66.81  ? 447 VAL A CB  1 
ATOM   3224 C  CG1 . VAL A 1 447 ? 97.514  116.153 112.965 1.00 66.81  ? 447 VAL A CG1 1 
ATOM   3225 C  CG2 . VAL A 1 447 ? 96.597  118.456 113.253 1.00 66.81  ? 447 VAL A CG2 1 
ATOM   3226 N  N   . THR A 1 448 ? 92.943  117.768 113.246 1.00 67.94  ? 448 THR A N   1 
ATOM   3227 C  CA  . THR A 1 448 ? 91.801  118.390 113.894 1.00 67.94  ? 448 THR A CA  1 
ATOM   3228 C  C   . THR A 1 448 ? 90.925  117.314 114.530 1.00 67.94  ? 448 THR A C   1 
ATOM   3229 O  O   . THR A 1 448 ? 91.266  116.129 114.549 1.00 67.94  ? 448 THR A O   1 
ATOM   3230 C  CB  . THR A 1 448 ? 91.007  119.226 112.894 1.00 67.94  ? 448 THR A CB  1 
ATOM   3231 O  OG1 . THR A 1 448 ? 90.216  118.363 112.072 1.00 67.94  ? 448 THR A OG1 1 
ATOM   3232 C  CG2 . THR A 1 448 ? 91.939  120.032 112.008 1.00 67.94  ? 448 THR A CG2 1 
ATOM   3233 N  N   . GLU A 1 449 ? 89.777  117.725 115.068 1.00 73.95  ? 449 GLU A N   1 
ATOM   3234 C  CA  . GLU A 1 449 ? 88.877  116.756 115.682 1.00 73.95  ? 449 GLU A CA  1 
ATOM   3235 C  C   . GLU A 1 449 ? 88.133  115.919 114.651 1.00 73.95  ? 449 GLU A C   1 
ATOM   3236 O  O   . GLU A 1 449 ? 87.608  114.856 114.997 1.00 73.95  ? 449 GLU A O   1 
ATOM   3237 C  CB  . GLU A 1 449 ? 87.883  117.465 116.600 1.00 73.95  ? 449 GLU A CB  1 
ATOM   3238 C  CG  . GLU A 1 449 ? 88.541  118.257 117.713 1.00 73.95  ? 449 GLU A CG  1 
ATOM   3239 C  CD  . GLU A 1 449 ? 87.549  118.759 118.739 1.00 73.95  ? 449 GLU A CD  1 
ATOM   3240 O  OE1 . GLU A 1 449 ? 86.780  117.935 119.276 1.00 73.95  ? 449 GLU A OE1 1 
ATOM   3241 O  OE2 . GLU A 1 449 ? 87.537  119.978 119.006 1.00 73.95  ? 449 GLU A OE2 1 
ATOM   3242 N  N   . GLY A 1 450 ? 88.075  116.369 113.402 1.00 68.65  ? 450 GLY A N   1 
ATOM   3243 C  CA  . GLY A 1 450 ? 87.461  115.599 112.340 1.00 68.65  ? 450 GLY A CA  1 
ATOM   3244 C  C   . GLY A 1 450 ? 88.455  115.218 111.264 1.00 68.65  ? 450 GLY A C   1 
ATOM   3245 O  O   . GLY A 1 450 ? 88.110  115.161 110.080 1.00 68.65  ? 450 GLY A O   1 
ATOM   3246 N  N   . GLY A 1 451 ? 89.704  114.977 111.666 1.00 63.91  ? 451 GLY A N   1 
ATOM   3247 C  CA  . GLY A 1 451 ? 90.737  114.656 110.694 1.00 63.91  ? 451 GLY A CA  1 
ATOM   3248 C  C   . GLY A 1 451 ? 90.749  113.194 110.293 1.00 63.91  ? 451 GLY A C   1 
ATOM   3249 O  O   . GLY A 1 451 ? 91.327  112.828 109.267 1.00 63.91  ? 451 GLY A O   1 
ATOM   3250 N  N   . MET A 1 452 ? 90.129  112.334 111.103 1.00 66.62  ? 452 MET A N   1 
ATOM   3251 C  CA  . MET A 1 452 ? 90.123  110.905 110.807 1.00 66.62  ? 452 MET A CA  1 
ATOM   3252 C  C   . MET A 1 452 ? 89.385  110.606 109.507 1.00 66.62  ? 452 MET A C   1 
ATOM   3253 O  O   . MET A 1 452 ? 89.802  109.745 108.726 1.00 66.62  ? 452 MET A O   1 
ATOM   3254 C  CB  . MET A 1 452 ? 89.498  110.131 111.965 1.00 66.62  ? 452 MET A CB  1 
ATOM   3255 C  CG  . MET A 1 452 ? 89.599  108.630 111.797 1.00 66.62  ? 452 MET A CG  1 
ATOM   3256 S  SD  . MET A 1 452 ? 91.309  108.072 111.853 1.00 66.62  ? 452 MET A SD  1 
ATOM   3257 C  CE  . MET A 1 452 ? 91.191  106.537 110.952 1.00 66.62  ? 452 MET A CE  1 
ATOM   3258 N  N   . TYR A 1 453 ? 88.267  111.294 109.271 1.00 61.32  ? 453 TYR A N   1 
ATOM   3259 C  CA  . TYR A 1 453 ? 87.513  111.085 108.039 1.00 61.32  ? 453 TYR A CA  1 
ATOM   3260 C  C   . TYR A 1 453 ? 88.318  111.516 106.822 1.00 61.32  ? 453 TYR A C   1 
ATOM   3261 O  O   . TYR A 1 453 ? 88.332  110.822 105.796 1.00 61.32  ? 453 TYR A O   1 
ATOM   3262 C  CB  . TYR A 1 453 ? 86.188  111.837 108.114 1.00 61.32  ? 453 TYR A CB  1 
ATOM   3263 C  CG  . TYR A 1 453 ? 85.368  111.456 109.321 1.00 61.32  ? 453 TYR A CG  1 
ATOM   3264 C  CD1 . TYR A 1 453 ? 84.680  110.255 109.363 1.00 61.32  ? 453 TYR A CD1 1 
ATOM   3265 C  CD2 . TYR A 1 453 ? 85.302  112.286 110.427 1.00 61.32  ? 453 TYR A CD2 1 
ATOM   3266 C  CE1 . TYR A 1 453 ? 83.936  109.899 110.465 1.00 61.32  ? 453 TYR A CE1 1 
ATOM   3267 C  CE2 . TYR A 1 453 ? 84.560  111.936 111.535 1.00 61.32  ? 453 TYR A CE2 1 
ATOM   3268 C  CZ  . TYR A 1 453 ? 83.880  110.742 111.548 1.00 61.32  ? 453 TYR A CZ  1 
ATOM   3269 O  OH  . TYR A 1 453 ? 83.139  110.389 112.648 1.00 61.32  ? 453 TYR A OH  1 
ATOM   3270 N  N   . VAL A 1 454 ? 89.007  112.654 106.921 1.00 59.95  ? 454 VAL A N   1 
ATOM   3271 C  CA  . VAL A 1 454 ? 89.884  113.089 105.840 1.00 59.95  ? 454 VAL A CA  1 
ATOM   3272 C  C   . VAL A 1 454 ? 90.997  112.075 105.621 1.00 59.95  ? 454 VAL A C   1 
ATOM   3273 O  O   . VAL A 1 454 ? 91.386  111.795 104.481 1.00 59.95  ? 454 VAL A O   1 
ATOM   3274 C  CB  . VAL A 1 454 ? 90.447  114.490 106.140 1.00 59.95  ? 454 VAL A CB  1 
ATOM   3275 C  CG1 . VAL A 1 454 ? 91.110  115.072 104.906 1.00 59.95  ? 454 VAL A CG1 1 
ATOM   3276 C  CG2 . VAL A 1 454 ? 89.348  115.406 106.644 1.00 59.95  ? 454 VAL A CG2 1 
ATOM   3277 N  N   . PHE A 1 455 ? 91.525  111.506 106.708 1.00 63.33  ? 455 PHE A N   1 
ATOM   3278 C  CA  . PHE A 1 455 ? 92.596  110.523 106.586 1.00 63.33  ? 455 PHE A CA  1 
ATOM   3279 C  C   . PHE A 1 455 ? 92.117  109.262 105.879 1.00 63.33  ? 455 PHE A C   1 
ATOM   3280 O  O   . PHE A 1 455 ? 92.818  108.720 105.020 1.00 63.33  ? 455 PHE A O   1 
ATOM   3281 C  CB  . PHE A 1 455 ? 93.160  110.176 107.963 1.00 63.33  ? 455 PHE A CB  1 
ATOM   3282 C  CG  . PHE A 1 455 ? 94.255  109.150 107.918 1.00 63.33  ? 455 PHE A CG  1 
ATOM   3283 C  CD1 . PHE A 1 455 ? 95.544  109.510 107.567 1.00 63.33  ? 455 PHE A CD1 1 
ATOM   3284 C  CD2 . PHE A 1 455 ? 93.992  107.823 108.204 1.00 63.33  ? 455 PHE A CD2 1 
ATOM   3285 C  CE1 . PHE A 1 455 ? 96.551  108.569 107.516 1.00 63.33  ? 455 PHE A CE1 1 
ATOM   3286 C  CE2 . PHE A 1 455 ? 94.995  106.880 108.152 1.00 63.33  ? 455 PHE A CE2 1 
ATOM   3287 C  CZ  . PHE A 1 455 ? 96.275  107.252 107.809 1.00 63.33  ? 455 PHE A CZ  1 
ATOM   3288 N  N   . GLN A 1 456 ? 90.931  108.768 106.241 1.00 62.82  ? 456 GLN A N   1 
ATOM   3289 C  CA  . GLN A 1 456 ? 90.403  107.577 105.584 1.00 62.82  ? 456 GLN A CA  1 
ATOM   3290 C  C   . GLN A 1 456 ? 90.105  107.846 104.116 1.00 62.82  ? 456 GLN A C   1 
ATOM   3291 O  O   . GLN A 1 456 ? 90.357  106.992 103.257 1.00 62.82  ? 456 GLN A O   1 
ATOM   3292 C  CB  . GLN A 1 456 ? 89.154  107.080 106.309 1.00 62.82  ? 456 GLN A CB  1 
ATOM   3293 C  CG  . GLN A 1 456 ? 88.352  106.048 105.530 1.00 62.82  ? 456 GLN A CG  1 
ATOM   3294 C  CD  . GLN A 1 456 ? 89.028  104.693 105.473 1.00 62.82  ? 456 GLN A CD  1 
ATOM   3295 O  OE1 . GLN A 1 456 ? 88.720  103.800 106.262 1.00 62.82  ? 456 GLN A OE1 1 
ATOM   3296 N  NE2 . GLN A 1 456 ? 89.947  104.528 104.530 1.00 62.82  ? 456 GLN A NE2 1 
ATOM   3297 N  N   . LEU A 1 457 ? 89.578  109.032 103.806 1.00 63.18  ? 457 LEU A N   1 
ATOM   3298 C  CA  . LEU A 1 457 ? 89.353  109.398 102.412 1.00 63.18  ? 457 LEU A CA  1 
ATOM   3299 C  C   . LEU A 1 457 ? 90.665  109.424 101.633 1.00 63.18  ? 457 LEU A C   1 
ATOM   3300 O  O   . LEU A 1 457 ? 90.735  108.933 100.498 1.00 63.18  ? 457 LEU A O   1 
ATOM   3301 C  CB  . LEU A 1 457 ? 88.652  110.756 102.350 1.00 63.18  ? 457 LEU A CB  1 
ATOM   3302 C  CG  . LEU A 1 457 ? 88.090  111.260 101.022 1.00 63.18  ? 457 LEU A CG  1 
ATOM   3303 C  CD1 . LEU A 1 457 ? 86.930  110.393 100.577 1.00 63.18  ? 457 LEU A CD1 1 
ATOM   3304 C  CD2 . LEU A 1 457 ? 87.657  112.705 101.154 1.00 63.18  ? 457 LEU A CD2 1 
ATOM   3305 N  N   . PHE A 1 458 ? 91.711  109.976 102.242 1.00 63.61  ? 458 PHE A N   1 
ATOM   3306 C  CA  . PHE A 1 458 ? 93.021  110.016 101.593 1.00 63.61  ? 458 PHE A CA  1 
ATOM   3307 C  C   . PHE A 1 458 ? 93.560  108.612 101.371 1.00 63.61  ? 458 PHE A C   1 
ATOM   3308 O  O   . PHE A 1 458 ? 94.027  108.282 100.292 1.00 63.61  ? 458 PHE A O   1 
ATOM   3309 C  CB  . PHE A 1 458 ? 94.013  110.820 102.433 1.00 63.61  ? 458 PHE A CB  1 
ATOM   3310 C  CG  . PHE A 1 458 ? 94.290  112.194 101.896 1.00 63.61  ? 458 PHE A CG  1 
ATOM   3311 C  CD1 . PHE A 1 458 ? 95.463  112.457 101.209 1.00 63.61  ? 458 PHE A CD1 1 
ATOM   3312 C  CD2 . PHE A 1 458 ? 93.380  113.221 102.075 1.00 63.61  ? 458 PHE A CD2 1 
ATOM   3313 C  CE1 . PHE A 1 458 ? 95.726  113.718 100.712 1.00 63.61  ? 458 PHE A CE1 1 
ATOM   3314 C  CE2 . PHE A 1 458 ? 93.636  114.486 101.581 1.00 63.61  ? 458 PHE A CE2 1 
ATOM   3315 C  CZ  . PHE A 1 458 ? 94.811  114.735 100.898 1.00 63.61  ? 458 PHE A CZ  1 
ATOM   3316 N  N   . ASP A 1 459 ? 93.470  107.765 102.384 1.00 64.11  ? 459 ASP A N   1 
ATOM   3317 C  CA  . ASP A 1 459 ? 94.018  106.424 102.259 1.00 64.11  ? 459 ASP A CA  1 
ATOM   3318 C  C   . ASP A 1 459 ? 93.314  105.669 101.142 1.00 64.11  ? 459 ASP A C   1 
ATOM   3319 O  O   . ASP A 1 459 ? 93.953  104.950 100.374 1.00 64.11  ? 459 ASP A O   1 
ATOM   3320 C  CB  . ASP A 1 459 ? 93.871  105.668 103.580 1.00 64.11  ? 459 ASP A CB  1 
ATOM   3321 C  CG  . ASP A 1 459 ? 94.343  104.234 103.485 1.00 64.11  ? 459 ASP A CG  1 
ATOM   3322 O  OD1 . ASP A 1 459 ? 95.572  104.008 103.463 1.00 64.11  ? 459 ASP A OD1 1 
ATOM   3323 O  OD2 . ASP A 1 459 ? 93.482  103.330 103.434 1.00 64.11  ? 459 ASP A OD2 1 
ATOM   3324 N  N   . TYR A 1 460 ? 92.003  105.841 101.034 1.00 65.58  ? 460 TYR A N   1 
ATOM   3325 C  CA  . TYR A 1 460 ? 91.234  105.106 100.035 1.00 65.58  ? 460 TYR A CA  1 
ATOM   3326 C  C   . TYR A 1 460 ? 91.328  105.652 98.610  1.00 65.58  ? 460 TYR A C   1 
ATOM   3327 O  O   . TYR A 1 460 ? 91.246  104.879 97.654  1.00 65.58  ? 460 TYR A O   1 
ATOM   3328 C  CB  . TYR A 1 460 ? 89.766  105.048 100.475 1.00 65.58  ? 460 TYR A CB  1 
ATOM   3329 C  CG  . TYR A 1 460 ? 88.914  104.037 99.740  1.00 65.58  ? 460 TYR A CG  1 
ATOM   3330 C  CD1 . TYR A 1 460 ? 88.957  102.691 100.073 1.00 65.58  ? 460 TYR A CD1 1 
ATOM   3331 C  CD2 . TYR A 1 460 ? 88.053  104.433 98.728  1.00 65.58  ? 460 TYR A CD2 1 
ATOM   3332 C  CE1 . TYR A 1 460 ? 88.174  101.766 99.408  1.00 65.58  ? 460 TYR A CE1 1 
ATOM   3333 C  CE2 . TYR A 1 460 ? 87.267  103.518 98.057  1.00 65.58  ? 460 TYR A CE2 1 
ATOM   3334 C  CZ  . TYR A 1 460 ? 87.331  102.186 98.401  1.00 65.58  ? 460 TYR A CZ  1 
ATOM   3335 O  OH  . TYR A 1 460 ? 86.547  101.276 97.732  1.00 65.58  ? 460 TYR A OH  1 
ATOM   3336 N  N   . TYR A 1 461 ? 91.513  106.961 98.443  1.00 67.49  ? 461 TYR A N   1 
ATOM   3337 C  CA  . TYR A 1 461 ? 91.487  107.522 97.094  1.00 67.49  ? 461 TYR A CA  1 
ATOM   3338 C  C   . TYR A 1 461 ? 92.821  108.069 96.608  1.00 67.49  ? 461 TYR A C   1 
ATOM   3339 O  O   . TYR A 1 461 ? 93.108  107.990 95.412  1.00 67.49  ? 461 TYR A O   1 
ATOM   3340 C  CB  . TYR A 1 461 ? 90.432  108.637 97.014  1.00 67.49  ? 461 TYR A CB  1 
ATOM   3341 C  CG  . TYR A 1 461 ? 89.016  108.135 96.851  1.00 67.49  ? 461 TYR A CG  1 
ATOM   3342 C  CD1 . TYR A 1 461 ? 88.522  107.787 95.602  1.00 67.49  ? 461 TYR A CD1 1 
ATOM   3343 C  CD2 . TYR A 1 461 ? 88.172  108.014 97.944  1.00 67.49  ? 461 TYR A CD2 1 
ATOM   3344 C  CE1 . TYR A 1 461 ? 87.231  107.327 95.450  1.00 67.49  ? 461 TYR A CE1 1 
ATOM   3345 C  CE2 . TYR A 1 461 ? 86.879  107.556 97.801  1.00 67.49  ? 461 TYR A CE2 1 
ATOM   3346 C  CZ  . TYR A 1 461 ? 86.414  107.214 96.552  1.00 67.49  ? 461 TYR A CZ  1 
ATOM   3347 O  OH  . TYR A 1 461 ? 85.125  106.758 96.405  1.00 67.49  ? 461 TYR A OH  1 
ATOM   3348 N  N   . ALA A 1 462 ? 93.640  108.639 97.492  1.00 66.97  ? 462 ALA A N   1 
ATOM   3349 C  CA  . ALA A 1 462 ? 94.820  109.398 97.089  1.00 66.97  ? 462 ALA A CA  1 
ATOM   3350 C  C   . ALA A 1 462 ? 95.877  108.561 96.380  1.00 66.97  ? 462 ALA A C   1 
ATOM   3351 O  O   . ALA A 1 462 ? 96.192  108.812 95.212  1.00 66.97  ? 462 ALA A O   1 
ATOM   3352 C  CB  . ALA A 1 462 ? 95.442  110.077 98.311  1.00 66.97  ? 462 ALA A CB  1 
ATOM   3353 N  N   . ALA A 1 463 ? 96.437  107.572 97.076  1.00 68.14  ? 463 ALA A N   1 
ATOM   3354 C  CA  . ALA A 1 463 ? 97.586  106.815 96.585  1.00 68.14  ? 463 ALA A CA  1 
ATOM   3355 C  C   . ALA A 1 463 ? 97.306  105.316 96.683  1.00 68.14  ? 463 ALA A C   1 
ATOM   3356 O  O   . ALA A 1 463 ? 98.130  104.534 97.152  1.00 68.14  ? 463 ALA A O   1 
ATOM   3357 C  CB  . ALA A 1 463 ? 98.850  107.177 97.360  1.00 68.14  ? 463 ALA A CB  1 
ATOM   3358 N  N   . SER A 1 464 ? 96.124  104.914 96.229  1.00 66.48  ? 464 SER A N   1 
ATOM   3359 C  CA  . SER A 1 464 ? 95.724  103.515 96.280  1.00 66.48  ? 464 SER A CA  1 
ATOM   3360 C  C   . SER A 1 464 ? 94.523  103.325 95.367  1.00 66.48  ? 464 SER A C   1 
ATOM   3361 O  O   . SER A 1 464 ? 93.939  104.288 94.866  1.00 66.48  ? 464 SER A O   1 
ATOM   3362 C  CB  . SER A 1 464 ? 95.394  103.076 97.706  1.00 66.48  ? 464 SER A CB  1 
ATOM   3363 O  OG  . SER A 1 464 ? 94.952  101.732 97.734  1.00 66.48  ? 464 SER A OG  1 
ATOM   3364 N  N   . GLY A 1 465 ? 94.170  102.063 95.149  1.00 68.97  ? 465 GLY A N   1 
ATOM   3365 C  CA  . GLY A 1 465 ? 92.967  101.730 94.418  1.00 68.97  ? 465 GLY A CA  1 
ATOM   3366 C  C   . GLY A 1 465 ? 93.061  101.881 92.915  1.00 68.97  ? 465 GLY A C   1 
ATOM   3367 O  O   . GLY A 1 465 ? 93.952  101.325 92.268  1.00 68.97  ? 465 GLY A O   1 
ATOM   3368 N  N   . VAL A 1 466 ? 92.126  102.648 92.355  1.00 70.61  ? 466 VAL A N   1 
ATOM   3369 C  CA  . VAL A 1 466 ? 91.927  102.695 90.910  1.00 70.61  ? 466 VAL A CA  1 
ATOM   3370 C  C   . VAL A 1 466 ? 93.044  103.446 90.188  1.00 70.61  ? 466 VAL A C   1 
ATOM   3371 O  O   . VAL A 1 466 ? 93.386  103.108 89.047  1.00 70.61  ? 466 VAL A O   1 
ATOM   3372 C  CB  . VAL A 1 466 ? 90.531  103.282 90.625  1.00 70.61  ? 466 VAL A CB  1 
ATOM   3373 C  CG1 . VAL A 1 466 ? 90.397  104.653 91.246  1.00 70.61  ? 466 VAL A CG1 1 
ATOM   3374 C  CG2 . VAL A 1 466 ? 90.268  103.337 89.137  1.00 70.61  ? 466 VAL A CG2 1 
ATOM   3375 N  N   . CYS A 1 467 ? 93.631  104.467 90.817  1.00 70.89  ? 467 CYS A N   1 
ATOM   3376 C  CA  . CYS A 1 467 ? 94.729  105.189 90.173  1.00 70.89  ? 467 CYS A CA  1 
ATOM   3377 C  C   . CYS A 1 467 ? 95.957  104.299 90.000  1.00 70.89  ? 467 CYS A C   1 
ATOM   3378 O  O   . CYS A 1 467 ? 96.652  104.369 88.973  1.00 70.89  ? 467 CYS A O   1 
ATOM   3379 C  CB  . CYS A 1 467 ? 95.071  106.447 90.973  1.00 70.89  ? 467 CYS A CB  1 
ATOM   3380 S  SG  . CYS A 1 467 ? 95.777  106.147 92.608  1.00 70.89  ? 467 CYS A SG  1 
ATOM   3381 N  N   . LEU A 1 468 ? 96.242  103.455 90.996  1.00 68.01  ? 468 LEU A N   1 
ATOM   3382 C  CA  . LEU A 1 468 ? 97.345  102.508 90.877  1.00 68.01  ? 468 LEU A CA  1 
ATOM   3383 C  C   . LEU A 1 468 ? 97.107  101.525 89.738  1.00 68.01  ? 468 LEU A C   1 
ATOM   3384 O  O   . LEU A 1 468 ? 98.029  101.217 88.975  1.00 68.01  ? 468 LEU A O   1 
ATOM   3385 C  CB  . LEU A 1 468 ? 97.542  101.762 92.196  1.00 68.01  ? 468 LEU A CB  1 
ATOM   3386 C  CG  . LEU A 1 468 ? 98.204  102.527 93.343  1.00 68.01  ? 468 LEU A CG  1 
ATOM   3387 C  CD1 . LEU A 1 468 ? 98.531  101.588 94.489  1.00 68.01  ? 468 LEU A CD1 1 
ATOM   3388 C  CD2 . LEU A 1 468 ? 99.451  103.250 92.869  1.00 68.01  ? 468 LEU A CD2 1 
ATOM   3389 N  N   . LEU A 1 469 ? 95.876  101.022 89.609  1.00 69.56  ? 469 LEU A N   1 
ATOM   3390 C  CA  . LEU A 1 469 ? 95.539  100.155 88.485  1.00 69.56  ? 469 LEU A CA  1 
ATOM   3391 C  C   . LEU A 1 469 ? 95.742  100.879 87.164  1.00 69.56  ? 469 LEU A C   1 
ATOM   3392 O  O   . LEU A 1 469 ? 96.284  100.313 86.209  1.00 69.56  ? 469 LEU A O   1 
ATOM   3393 C  CB  . LEU A 1 469 ? 94.095  99.672  88.608  1.00 69.56  ? 469 LEU A CB  1 
ATOM   3394 C  CG  . LEU A 1 469 ? 93.820  98.327  89.279  1.00 69.56  ? 469 LEU A CG  1 
ATOM   3395 C  CD1 . LEU A 1 469 ? 94.474  98.246  90.637  1.00 69.56  ? 469 LEU A CD1 1 
ATOM   3396 C  CD2 . LEU A 1 469 ? 92.323  98.114  89.403  1.00 69.56  ? 469 LEU A CD2 1 
ATOM   3397 N  N   . TRP A 1 470 ? 95.313  102.139 87.096  1.00 70.93  ? 470 TRP A N   1 
ATOM   3398 C  CA  . TRP A 1 470 ? 95.474  102.938 85.886  1.00 70.93  ? 470 TRP A CA  1 
ATOM   3399 C  C   . TRP A 1 470 ? 96.938  102.998 85.458  1.00 70.93  ? 470 TRP A C   1 
ATOM   3400 O  O   . TRP A 1 470 ? 97.293  102.637 84.323  1.00 70.93  ? 470 TRP A O   1 
ATOM   3401 C  CB  . TRP A 1 470 ? 94.916  104.338 86.154  1.00 70.93  ? 470 TRP A CB  1 
ATOM   3402 C  CG  . TRP A 1 470 ? 94.750  105.230 84.969  1.00 70.93  ? 470 TRP A CG  1 
ATOM   3403 C  CD1 . TRP A 1 470 ? 95.645  106.144 84.502  1.00 70.93  ? 470 TRP A CD1 1 
ATOM   3404 C  CD2 . TRP A 1 470 ? 93.599  105.328 84.123  1.00 70.93  ? 470 TRP A CD2 1 
ATOM   3405 N  NE1 . TRP A 1 470 ? 95.133  106.791 83.406  1.00 70.93  ? 470 TRP A NE1 1 
ATOM   3406 C  CE2 . TRP A 1 470 ? 93.877  106.308 83.153  1.00 70.93  ? 470 TRP A CE2 1 
ATOM   3407 C  CE3 . TRP A 1 470 ? 92.365  104.674 84.085  1.00 70.93  ? 470 TRP A CE3 1 
ATOM   3408 C  CZ2 . TRP A 1 470 ? 92.968  106.651 82.157  1.00 70.93  ? 470 TRP A CZ2 1 
ATOM   3409 C  CZ3 . TRP A 1 470 ? 91.465  105.016 83.096  1.00 70.93  ? 470 TRP A CZ3 1 
ATOM   3410 C  CH2 . TRP A 1 470 ? 91.770  105.994 82.145  1.00 70.93  ? 470 TRP A CH2 1 
ATOM   3411 N  N   . VAL A 1 471 ? 97.814  103.401 86.382  1.00 73.90  ? 471 VAL A N   1 
ATOM   3412 C  CA  . VAL A 1 471 ? 99.217  103.597 86.021  1.00 73.90  ? 471 VAL A CA  1 
ATOM   3413 C  C   . VAL A 1 471 ? 99.906  102.262 85.742  1.00 73.90  ? 471 VAL A C   1 
ATOM   3414 O  O   . VAL A 1 471 ? 100.720 102.159 84.816  1.00 73.90  ? 471 VAL A O   1 
ATOM   3415 C  CB  . VAL A 1 471 ? 99.952  104.414 87.100  1.00 73.90  ? 471 VAL A CB  1 
ATOM   3416 C  CG1 . VAL A 1 471 ? 99.439  105.844 87.118  1.00 73.90  ? 471 VAL A CG1 1 
ATOM   3417 C  CG2 . VAL A 1 471 ? 99.778  103.786 88.461  1.00 73.90  ? 471 VAL A CG2 1 
ATOM   3418 N  N   . ALA A 1 472 ? 99.600  101.221 86.523  1.00 71.92  ? 472 ALA A N   1 
ATOM   3419 C  CA  . ALA A 1 472 ? 100.230 99.924  86.291  1.00 71.92  ? 472 ALA A CA  1 
ATOM   3420 C  C   . ALA A 1 472 ? 99.818  99.335  84.950  1.00 71.92  ? 472 ALA A C   1 
ATOM   3421 O  O   . ALA A 1 472 ? 100.656 98.789  84.217  1.00 71.92  ? 472 ALA A O   1 
ATOM   3422 C  CB  . ALA A 1 472 ? 99.883  98.960  87.423  1.00 71.92  ? 472 ALA A CB  1 
ATOM   3423 N  N   . PHE A 1 473 ? 98.528  99.425  84.612  1.00 71.15  ? 473 PHE A N   1 
ATOM   3424 C  CA  . PHE A 1 473 ? 98.071  98.940  83.319  1.00 71.15  ? 473 PHE A CA  1 
ATOM   3425 C  C   . PHE A 1 473 ? 98.762  99.685  82.192  1.00 71.15  ? 473 PHE A C   1 
ATOM   3426 O  O   . PHE A 1 473 ? 99.197  99.072  81.211  1.00 71.15  ? 473 PHE A O   1 
ATOM   3427 C  CB  . PHE A 1 473 ? 96.551  99.086  83.204  1.00 71.15  ? 473 PHE A CB  1 
ATOM   3428 C  CG  . PHE A 1 473 ? 96.030  98.952  81.796  1.00 71.15  ? 473 PHE A CG  1 
ATOM   3429 C  CD1 . PHE A 1 473 ? 95.842  100.069 80.997  1.00 71.15  ? 473 PHE A CD1 1 
ATOM   3430 C  CD2 . PHE A 1 473 ? 95.714  97.710  81.276  1.00 71.15  ? 473 PHE A CD2 1 
ATOM   3431 C  CE1 . PHE A 1 473 ? 95.368  99.945  79.709  1.00 71.15  ? 473 PHE A CE1 1 
ATOM   3432 C  CE2 . PHE A 1 473 ? 95.235  97.583  79.988  1.00 71.15  ? 473 PHE A CE2 1 
ATOM   3433 C  CZ  . PHE A 1 473 ? 95.063  98.701  79.206  1.00 71.15  ? 473 PHE A CZ  1 
ATOM   3434 N  N   . PHE A 1 474 ? 98.877  101.010 82.312  1.00 73.30  ? 474 PHE A N   1 
ATOM   3435 C  CA  . PHE A 1 474 ? 99.519  101.756 81.236  1.00 73.30  ? 474 PHE A CA  1 
ATOM   3436 C  C   . PHE A 1 474 ? 100.998 101.401 81.113  1.00 73.30  ? 474 PHE A C   1 
ATOM   3437 O  O   . PHE A 1 474 ? 101.518 101.287 79.998  1.00 73.30  ? 474 PHE A O   1 
ATOM   3438 C  CB  . PHE A 1 474 ? 99.315  103.255 81.438  1.00 73.30  ? 474 PHE A CB  1 
ATOM   3439 C  CG  . PHE A 1 474 ? 98.137  103.795 80.683  1.00 73.30  ? 474 PHE A CG  1 
ATOM   3440 C  CD1 . PHE A 1 474 ? 98.274  104.223 79.374  1.00 73.30  ? 474 PHE A CD1 1 
ATOM   3441 C  CD2 . PHE A 1 474 ? 96.885  103.847 81.272  1.00 73.30  ? 474 PHE A CD2 1 
ATOM   3442 C  CE1 . PHE A 1 474 ? 97.190  104.707 78.674  1.00 73.30  ? 474 PHE A CE1 1 
ATOM   3443 C  CE2 . PHE A 1 474 ? 95.797  104.331 80.576  1.00 73.30  ? 474 PHE A CE2 1 
ATOM   3444 C  CZ  . PHE A 1 474 ? 95.950  104.762 79.275  1.00 73.30  ? 474 PHE A CZ  1 
ATOM   3445 N  N   . GLU A 1 475 ? 101.685 101.195 82.241  1.00 76.58  ? 475 GLU A N   1 
ATOM   3446 C  CA  . GLU A 1 475 ? 103.089 100.788 82.196  1.00 76.58  ? 475 GLU A CA  1 
ATOM   3447 C  C   . GLU A 1 475 ? 103.258 99.455  81.477  1.00 76.58  ? 475 GLU A C   1 
ATOM   3448 O  O   . GLU A 1 475 ? 104.062 99.333  80.540  1.00 76.58  ? 475 GLU A O   1 
ATOM   3449 C  CB  . GLU A 1 475 ? 103.653 100.690 83.613  1.00 76.58  ? 475 GLU A CB  1 
ATOM   3450 C  CG  . GLU A 1 475 ? 104.160 101.992 84.191  1.00 76.58  ? 475 GLU A CG  1 
ATOM   3451 C  CD  . GLU A 1 475 ? 104.714 101.820 85.590  1.00 76.58  ? 475 GLU A CD  1 
ATOM   3452 O  OE1 . GLU A 1 475 ? 104.637 100.695 86.125  1.00 76.58  ? 475 GLU A OE1 1 
ATOM   3453 O  OE2 . GLU A 1 475 ? 105.226 102.807 86.156  1.00 76.58  ? 475 GLU A OE2 1 
ATOM   3454 N  N   . CYS A 1 476 ? 102.504 98.439  81.908  1.00 73.21  ? 476 CYS A N   1 
ATOM   3455 C  CA  . CYS A 1 476 ? 102.634 97.120  81.297  1.00 73.21  ? 476 CYS A CA  1 
ATOM   3456 C  C   . CYS A 1 476 ? 102.268 97.158  79.820  1.00 73.21  ? 476 CYS A C   1 
ATOM   3457 O  O   . CYS A 1 476 ? 102.954 96.552  78.988  1.00 73.21  ? 476 CYS A O   1 
ATOM   3458 C  CB  . CYS A 1 476 ? 101.767 96.106  82.039  1.00 73.21  ? 476 CYS A CB  1 
ATOM   3459 S  SG  . CYS A 1 476 ? 102.528 95.432  83.525  1.00 73.21  ? 476 CYS A SG  1 
ATOM   3460 N  N   . PHE A 1 477 ? 101.199 97.879  79.471  1.00 72.28  ? 477 PHE A N   1 
ATOM   3461 C  CA  . PHE A 1 477 ? 100.792 97.969  78.076  1.00 72.28  ? 477 PHE A CA  1 
ATOM   3462 C  C   . PHE A 1 477 ? 101.859 98.638  77.219  1.00 72.28  ? 477 PHE A C   1 
ATOM   3463 O  O   . PHE A 1 477 ? 102.227 98.102  76.166  1.00 72.28  ? 477 PHE A O   1 
ATOM   3464 C  CB  . PHE A 1 477 ? 99.460  98.719  77.978  1.00 72.28  ? 477 PHE A CB  1 
ATOM   3465 C  CG  . PHE A 1 477 ? 99.055  99.078  76.576  1.00 72.28  ? 477 PHE A CG  1 
ATOM   3466 C  CD1 . PHE A 1 477 ? 99.376  100.312 76.036  1.00 72.28  ? 477 PHE A CD1 1 
ATOM   3467 C  CD2 . PHE A 1 477 ? 98.342  98.181  75.800  1.00 72.28  ? 477 PHE A CD2 1 
ATOM   3468 C  CE1 . PHE A 1 477 ? 99.002  100.640 74.750  1.00 72.28  ? 477 PHE A CE1 1 
ATOM   3469 C  CE2 . PHE A 1 477 ? 97.965  98.505  74.513  1.00 72.28  ? 477 PHE A CE2 1 
ATOM   3470 C  CZ  . PHE A 1 477 ? 98.296  99.736  73.988  1.00 72.28  ? 477 PHE A CZ  1 
ATOM   3471 N  N   . VAL A 1 478 ? 102.378 99.791  77.649  1.00 77.90  ? 478 VAL A N   1 
ATOM   3472 C  CA  . VAL A 1 478 ? 103.355 100.497 76.828  1.00 77.90  ? 478 VAL A CA  1 
ATOM   3473 C  C   . VAL A 1 478 ? 104.659 99.722  76.713  1.00 77.90  ? 478 VAL A C   1 
ATOM   3474 O  O   . VAL A 1 478 ? 105.328 99.806  75.676  1.00 77.90  ? 478 VAL A O   1 
ATOM   3475 C  CB  . VAL A 1 478 ? 103.623 101.918 77.360  1.00 77.90  ? 478 VAL A CB  1 
ATOM   3476 C  CG1 . VAL A 1 478 ? 104.279 101.881 78.727  1.00 77.90  ? 478 VAL A CG1 1 
ATOM   3477 C  CG2 . VAL A 1 478 ? 104.472 102.713 76.379  1.00 77.90  ? 478 VAL A CG2 1 
ATOM   3478 N  N   . ILE A 1 479 ? 105.036 98.946  77.731  1.00 77.54  ? 479 ILE A N   1 
ATOM   3479 C  CA  . ILE A 1 479 ? 106.280 98.193  77.644  1.00 77.54  ? 479 ILE A CA  1 
ATOM   3480 C  C   . ILE A 1 479 ? 106.124 96.874  76.890  1.00 77.54  ? 479 ILE A C   1 
ATOM   3481 O  O   . ILE A 1 479 ? 107.114 96.377  76.332  1.00 77.54  ? 479 ILE A O   1 
ATOM   3482 C  CB  . ILE A 1 479 ? 106.876 97.937  79.043  1.00 77.54  ? 479 ILE A CB  1 
ATOM   3483 C  CG1 . ILE A 1 479 ? 108.361 97.604  78.926  1.00 77.54  ? 479 ILE A CG1 1 
ATOM   3484 C  CG2 . ILE A 1 479 ? 106.148 96.803  79.734  1.00 77.54  ? 479 ILE A CG2 1 
ATOM   3485 C  CD1 . ILE A 1 479 ? 109.198 98.753  78.413  1.00 77.54  ? 479 ILE A CD1 1 
ATOM   3486 N  N   . ALA A 1 480 ? 104.919 96.306  76.832  1.00 74.48  ? 480 ALA A N   1 
ATOM   3487 C  CA  . ALA A 1 480 ? 104.736 95.004  76.207  1.00 74.48  ? 480 ALA A CA  1 
ATOM   3488 C  C   . ALA A 1 480 ? 104.229 95.072  74.776  1.00 74.48  ? 480 ALA A C   1 
ATOM   3489 O  O   . ALA A 1 480 ? 104.534 94.172  73.988  1.00 74.48  ? 480 ALA A O   1 
ATOM   3490 C  CB  . ALA A 1 480 ? 103.770 94.150  77.034  1.00 74.48  ? 480 ALA A CB  1 
ATOM   3491 N  N   . TRP A 1 481 ? 103.465 96.102  74.406  1.00 73.51  ? 481 TRP A N   1 
ATOM   3492 C  CA  . TRP A 1 481 ? 102.889 96.169  73.070  1.00 73.51  ? 481 TRP A CA  1 
ATOM   3493 C  C   . TRP A 1 481 ? 103.437 97.293  72.208  1.00 73.51  ? 481 TRP A C   1 
ATOM   3494 O  O   . TRP A 1 481 ? 103.350 97.204  70.983  1.00 73.51  ? 481 TRP A O   1 
ATOM   3495 C  CB  . TRP A 1 481 ? 101.365 96.308  73.159  1.00 73.51  ? 481 TRP A CB  1 
ATOM   3496 C  CG  . TRP A 1 481 ? 100.714 95.131  73.806  1.00 73.51  ? 481 TRP A CG  1 
ATOM   3497 C  CD1 . TRP A 1 481 ? 100.257 95.048  75.086  1.00 73.51  ? 481 TRP A CD1 1 
ATOM   3498 C  CD2 . TRP A 1 481 ? 100.450 93.862  73.202  1.00 73.51  ? 481 TRP A CD2 1 
ATOM   3499 N  NE1 . TRP A 1 481 ? 99.724  93.804  75.318  1.00 73.51  ? 481 TRP A NE1 1 
ATOM   3500 C  CE2 . TRP A 1 481 ? 99.830  93.057  74.175  1.00 73.51  ? 481 TRP A CE2 1 
ATOM   3501 C  CE3 . TRP A 1 481 ? 100.678 93.328  71.931  1.00 73.51  ? 481 TRP A CE3 1 
ATOM   3502 C  CZ2 . TRP A 1 481 ? 99.435  91.749  73.917  1.00 73.51  ? 481 TRP A CZ2 1 
ATOM   3503 C  CZ3 . TRP A 1 481 ? 100.286 92.031  71.677  1.00 73.51  ? 481 TRP A CZ3 1 
ATOM   3504 C  CH2 . TRP A 1 481 ? 99.672  91.255  72.664  1.00 73.51  ? 481 TRP A CH2 1 
ATOM   3505 N  N   . ILE A 1 482 ? 103.994 98.341  72.804  1.00 79.15  ? 482 ILE A N   1 
ATOM   3506 C  CA  . ILE A 1 482 ? 104.564 99.448  72.048  1.00 79.15  ? 482 ILE A CA  1 
ATOM   3507 C  C   . ILE A 1 482 ? 106.069 99.289  71.870  1.00 79.15  ? 482 ILE A C   1 
ATOM   3508 O  O   . ILE A 1 482 ? 106.604 99.582  70.800  1.00 79.15  ? 482 ILE A O   1 
ATOM   3509 C  CB  . ILE A 1 482 ? 104.224 100.792 72.727  1.00 79.15  ? 482 ILE A CB  1 
ATOM   3510 C  CG1 . ILE A 1 482 ? 102.710 100.975 72.826  1.00 79.15  ? 482 ILE A CG1 1 
ATOM   3511 C  CG2 . ILE A 1 482 ? 104.827 101.949 71.950  1.00 79.15  ? 482 ILE A CG2 1 
ATOM   3512 C  CD1 . ILE A 1 482 ? 102.013 101.001 71.489  1.00 79.15  ? 482 ILE A CD1 1 
ATOM   3513 N  N   . TYR A 1 483 ? 106.765 98.818  72.904  1.00 85.02  ? 483 TYR A N   1 
ATOM   3514 C  CA  . TYR A 1 483 ? 108.217 98.692  72.880  1.00 85.02  ? 483 TYR A CA  1 
ATOM   3515 C  C   . TYR A 1 483 ? 108.676 97.296  72.473  1.00 85.02  ? 483 TYR A C   1 
ATOM   3516 O  O   . TYR A 1 483 ? 109.549 97.159  71.613  1.00 85.02  ? 483 TYR A O   1 
ATOM   3517 C  CB  . TYR A 1 483 ? 108.794 99.059  74.253  1.00 85.02  ? 483 TYR A CB  1 
ATOM   3518 C  CG  . TYR A 1 483 ? 110.302 99.001  74.321  1.00 85.02  ? 483 TYR A CG  1 
ATOM   3519 C  CD1 . TYR A 1 483 ? 110.947 98.118  75.175  1.00 85.02  ? 483 TYR A CD1 1 
ATOM   3520 C  CD2 . TYR A 1 483 ? 111.080 99.837  73.533  1.00 85.02  ? 483 TYR A CD2 1 
ATOM   3521 C  CE1 . TYR A 1 483 ? 112.326 98.067  75.238  1.00 85.02  ? 483 TYR A CE1 1 
ATOM   3522 C  CE2 . TYR A 1 483 ? 112.457 99.793  73.589  1.00 85.02  ? 483 TYR A CE2 1 
ATOM   3523 C  CZ  . TYR A 1 483 ? 113.074 98.907  74.441  1.00 85.02  ? 483 TYR A CZ  1 
ATOM   3524 O  OH  . TYR A 1 483 ? 114.446 98.864  74.496  1.00 85.02  ? 483 TYR A OH  1 
ATOM   3525 N  N   . GLY A 1 484 ? 108.108 96.254  73.075  1.00 85.91  ? 484 GLY A N   1 
ATOM   3526 C  CA  . GLY A 1 484 ? 108.440 94.893  72.703  1.00 85.91  ? 484 GLY A CA  1 
ATOM   3527 C  C   . GLY A 1 484 ? 109.118 94.101  73.802  1.00 85.91  ? 484 GLY A C   1 
ATOM   3528 O  O   . GLY A 1 484 ? 110.134 94.534  74.350  1.00 85.91  ? 484 GLY A O   1 
ATOM   3529 N  N   . GLY A 1 485 ? 108.557 92.938  74.139  1.00 86.60  ? 485 GLY A N   1 
ATOM   3530 C  CA  . GLY A 1 485 ? 109.173 92.095  75.152  1.00 86.60  ? 485 GLY A CA  1 
ATOM   3531 C  C   . GLY A 1 485 ? 110.502 91.511  74.711  1.00 86.60  ? 485 GLY A C   1 
ATOM   3532 O  O   . GLY A 1 485 ? 111.458 91.465  75.488  1.00 86.60  ? 485 GLY A O   1 
ATOM   3533 N  N   . ASP A 1 486 ? 110.577 91.045  73.462  1.00 90.21  ? 486 ASP A N   1 
ATOM   3534 C  CA  . ASP A 1 486 ? 111.820 90.476  72.946  1.00 90.21  ? 486 ASP A CA  1 
ATOM   3535 C  C   . ASP A 1 486 ? 112.911 91.538  72.853  1.00 90.21  ? 486 ASP A C   1 
ATOM   3536 O  O   . ASP A 1 486 ? 114.086 91.274  73.147  1.00 90.21  ? 486 ASP A O   1 
ATOM   3537 C  CB  . ASP A 1 486 ? 111.565 89.836  71.580  1.00 90.21  ? 486 ASP A CB  1 
ATOM   3538 C  CG  . ASP A 1 486 ? 112.689 88.916  71.142  1.00 90.21  ? 486 ASP A CG  1 
ATOM   3539 O  OD1 . ASP A 1 486 ? 113.674 88.766  71.895  1.00 90.21  ? 486 ASP A OD1 1 
ATOM   3540 O  OD2 . ASP A 1 486 ? 112.585 88.336  70.041  1.00 90.21  ? 486 ASP A OD2 1 
ATOM   3541 N  N   . ASN A 1 487 ? 112.535 92.750  72.438  1.00 88.14  ? 487 ASN A N   1 
ATOM   3542 C  CA  . ASN A 1 487 ? 113.497 93.843  72.365  1.00 88.14  ? 487 ASN A CA  1 
ATOM   3543 C  C   . ASN A 1 487 ? 114.094 94.133  73.733  1.00 88.14  ? 487 ASN A C   1 
ATOM   3544 O  O   . ASN A 1 487 ? 115.295 94.402  73.853  1.00 88.14  ? 487 ASN A O   1 
ATOM   3545 C  CB  . ASN A 1 487 ? 112.823 95.091  71.798  1.00 88.14  ? 487 ASN A CB  1 
ATOM   3546 C  CG  . ASN A 1 487 ? 112.481 94.950  70.333  1.00 88.14  ? 487 ASN A CG  1 
ATOM   3547 O  OD1 . ASN A 1 487 ? 113.268 94.424  69.548  1.00 88.14  ? 487 ASN A OD1 1 
ATOM   3548 N  ND2 . ASN A 1 487 ? 111.298 95.418  69.955  1.00 88.14  ? 487 ASN A ND2 1 
ATOM   3549 N  N   . LEU A 1 488 ? 113.269 94.087  74.779  1.00 86.73  ? 488 LEU A N   1 
ATOM   3550 C  CA  . LEU A 1 488 ? 113.794 94.235  76.129  1.00 86.73  ? 488 LEU A CA  1 
ATOM   3551 C  C   . LEU A 1 488 ? 114.691 93.061  76.499  1.00 86.73  ? 488 LEU A C   1 
ATOM   3552 O  O   . LEU A 1 488 ? 115.816 93.262  76.971  1.00 86.73  ? 488 LEU A O   1 
ATOM   3553 C  CB  . LEU A 1 488 ? 112.647 94.375  77.129  1.00 86.73  ? 488 LEU A CB  1 
ATOM   3554 C  CG  . LEU A 1 488 ? 112.977 95.083  78.445  1.00 86.73  ? 488 LEU A CG  1 
ATOM   3555 C  CD1 . LEU A 1 488 ? 113.832 96.316  78.203  1.00 86.73  ? 488 LEU A CD1 1 
ATOM   3556 C  CD2 . LEU A 1 488 ? 111.714 95.445  79.203  1.00 86.73  ? 488 LEU A CD2 1 
ATOM   3557 N  N   . TYR A 1 489 ? 114.228 91.829  76.254  1.00 87.28  ? 489 TYR A N   1 
ATOM   3558 C  CA  . TYR A 1 489 ? 115.007 90.649  76.625  1.00 87.28  ? 489 TYR A CA  1 
ATOM   3559 C  C   . TYR A 1 489 ? 116.404 90.687  76.027  1.00 87.28  ? 489 TYR A C   1 
ATOM   3560 O  O   . TYR A 1 489 ? 117.364 90.213  76.643  1.00 87.28  ? 489 TYR A O   1 
ATOM   3561 C  CB  . TYR A 1 489 ? 114.289 89.370  76.193  1.00 87.28  ? 489 TYR A CB  1 
ATOM   3562 C  CG  . TYR A 1 489 ? 113.337 88.816  77.222  1.00 87.28  ? 489 TYR A CG  1 
ATOM   3563 C  CD1 . TYR A 1 489 ? 112.775 87.560  77.064  1.00 87.28  ? 489 TYR A CD1 1 
ATOM   3564 C  CD2 . TYR A 1 489 ? 113.003 89.545  78.351  1.00 87.28  ? 489 TYR A CD2 1 
ATOM   3565 C  CE1 . TYR A 1 489 ? 111.909 87.045  78.002  1.00 87.28  ? 489 TYR A CE1 1 
ATOM   3566 C  CE2 . TYR A 1 489 ? 112.135 89.038  79.294  1.00 87.28  ? 489 TYR A CE2 1 
ATOM   3567 C  CZ  . TYR A 1 489 ? 111.592 87.788  79.115  1.00 87.28  ? 489 TYR A CZ  1 
ATOM   3568 O  OH  . TYR A 1 489 ? 110.726 87.278  80.052  1.00 87.28  ? 489 TYR A OH  1 
ATOM   3569 N  N   . ASP A 1 490 ? 116.540 91.254  74.828  1.00 91.36  ? 490 ASP A N   1 
ATOM   3570 C  CA  . ASP A 1 490 ? 117.871 91.442  74.259  1.00 91.36  ? 490 ASP A CA  1 
ATOM   3571 C  C   . ASP A 1 490 ? 118.728 92.323  75.165  1.00 91.36  ? 490 ASP A C   1 
ATOM   3572 O  O   . ASP A 1 490 ? 119.896 92.017  75.438  1.00 91.36  ? 490 ASP A O   1 
ATOM   3573 C  CB  . ASP A 1 490 ? 117.763 92.044  72.858  1.00 91.36  ? 490 ASP A CB  1 
ATOM   3574 C  CG  . ASP A 1 490 ? 117.227 91.057  71.846  1.00 91.36  ? 490 ASP A CG  1 
ATOM   3575 O  OD1 . ASP A 1 490 ? 117.427 89.840  72.043  1.00 91.36  ? 490 ASP A OD1 1 
ATOM   3576 O  OD2 . ASP A 1 490 ? 116.607 91.497  70.854  1.00 91.36  ? 490 ASP A OD2 1 
ATOM   3577 N  N   . GLY A 1 491 ? 118.146 93.417  75.662  1.00 91.88  ? 491 GLY A N   1 
ATOM   3578 C  CA  . GLY A 1 491 ? 118.878 94.291  76.566  1.00 91.88  ? 491 GLY A CA  1 
ATOM   3579 C  C   . GLY A 1 491 ? 119.258 93.614  77.869  1.00 91.88  ? 491 GLY A C   1 
ATOM   3580 O  O   . GLY A 1 491 ? 120.394 93.738  78.332  1.00 91.88  ? 491 GLY A O   1 
ATOM   3581 N  N   . ILE A 1 492 ? 118.315 92.891  78.480  1.00 90.70  ? 492 ILE A N   1 
ATOM   3582 C  CA  . ILE A 1 492 ? 118.652 92.157  79.703  1.00 90.70  ? 492 ILE A CA  1 
ATOM   3583 C  C   . ILE A 1 492 ? 119.789 91.176  79.445  1.00 90.70  ? 492 ILE A C   1 
ATOM   3584 O  O   . ILE A 1 492 ? 120.780 91.154  80.182  1.00 90.70  ? 492 ILE A O   1 
ATOM   3585 C  CB  . ILE A 1 492 ? 117.431 91.448  80.323  1.00 90.70  ? 492 ILE A CB  1 
ATOM   3586 C  CG1 . ILE A 1 492 ? 116.354 92.428  80.792  1.00 90.70  ? 492 ILE A CG1 1 
ATOM   3587 C  CG2 . ILE A 1 492 ? 117.859 90.575  81.487  1.00 90.70  ? 492 ILE A CG2 1 
ATOM   3588 C  CD1 . ILE A 1 492 ? 115.342 92.796  79.802  1.00 90.70  ? 492 ILE A CD1 1 
ATOM   3589 N  N   . GLU A 1 493 ? 119.683 90.371  78.384  1.00 92.41  ? 493 GLU A N   1 
ATOM   3590 C  CA  . GLU A 1 493 ? 120.739 89.403  78.098  1.00 92.41  ? 493 GLU A CA  1 
ATOM   3591 C  C   . GLU A 1 493 ? 122.077 90.096  77.882  1.00 92.41  ? 493 GLU A C   1 
ATOM   3592 O  O   . GLU A 1 493 ? 123.128 89.565  78.258  1.00 92.41  ? 493 GLU A O   1 
ATOM   3593 C  CB  . GLU A 1 493 ? 120.378 88.555  76.880  1.00 92.41  ? 493 GLU A CB  1 
ATOM   3594 C  CG  . GLU A 1 493 ? 121.403 87.473  76.579  1.00 92.41  ? 493 GLU A CG  1 
ATOM   3595 C  CD  . GLU A 1 493 ? 121.019 86.601  75.403  1.00 92.41  ? 493 GLU A CD  1 
ATOM   3596 O  OE1 . GLU A 1 493 ? 119.956 86.848  74.797  1.00 92.41  ? 493 GLU A OE1 1 
ATOM   3597 O  OE2 . GLU A 1 493 ? 121.782 85.665  75.085  1.00 92.41  ? 493 GLU A OE2 1 
ATOM   3598 N  N   . ASP A 1 494 ? 122.060 91.286  77.280  1.00 95.44  ? 494 ASP A N   1 
ATOM   3599 C  CA  . ASP A 1 494 ? 123.294 92.051  77.150  1.00 95.44  ? 494 ASP A CA  1 
ATOM   3600 C  C   . ASP A 1 494 ? 123.819 92.492  78.512  1.00 95.44  ? 494 ASP A C   1 
ATOM   3601 O  O   . ASP A 1 494 ? 125.034 92.582  78.717  1.00 95.44  ? 494 ASP A O   1 
ATOM   3602 C  CB  . ASP A 1 494 ? 123.070 93.261  76.245  1.00 95.44  ? 494 ASP A CB  1 
ATOM   3603 C  CG  . ASP A 1 494 ? 124.367 93.844  75.725  1.00 95.44  ? 494 ASP A CG  1 
ATOM   3604 O  OD1 . ASP A 1 494 ? 124.777 94.915  76.218  1.00 95.44  ? 494 ASP A OD1 1 
ATOM   3605 O  OD2 . ASP A 1 494 ? 124.980 93.230  74.826  1.00 95.44  ? 494 ASP A OD2 1 
ATOM   3606 N  N   . MET A 1 495 ? 122.920 92.770  79.455  1.00 93.30  ? 495 MET A N   1 
ATOM   3607 C  CA  . MET A 1 495 ? 123.301 93.308  80.754  1.00 93.30  ? 495 MET A CA  1 
ATOM   3608 C  C   . MET A 1 495 ? 123.422 92.254  81.849  1.00 93.30  ? 495 MET A C   1 
ATOM   3609 O  O   . MET A 1 495 ? 123.991 92.550  82.903  1.00 93.30  ? 495 MET A O   1 
ATOM   3610 C  CB  . MET A 1 495 ? 122.298 94.379  81.193  1.00 93.30  ? 495 MET A CB  1 
ATOM   3611 C  CG  . MET A 1 495 ? 122.153 95.535  80.222  1.00 93.30  ? 495 MET A CG  1 
ATOM   3612 S  SD  . MET A 1 495 ? 121.173 96.888  80.898  1.00 93.30  ? 495 MET A SD  1 
ATOM   3613 C  CE  . MET A 1 495 ? 120.065 95.995  81.983  1.00 93.30  ? 495 MET A CE  1 
ATOM   3614 N  N   . ILE A 1 496 ? 122.909 91.042  81.643  1.00 93.65  ? 496 ILE A N   1 
ATOM   3615 C  CA  . ILE A 1 496 ? 122.900 90.039  82.696  1.00 93.65  ? 496 ILE A CA  1 
ATOM   3616 C  C   . ILE A 1 496 ? 123.790 88.840  82.377  1.00 93.65  ? 496 ILE A C   1 
ATOM   3617 O  O   . ILE A 1 496 ? 124.321 88.217  83.305  1.00 93.65  ? 496 ILE A O   1 
ATOM   3618 C  CB  . ILE A 1 496 ? 121.458 89.582  83.008  1.00 93.65  ? 496 ILE A CB  1 
ATOM   3619 C  CG1 . ILE A 1 496 ? 121.406 88.788  84.306  1.00 93.65  ? 496 ILE A CG1 1 
ATOM   3620 C  CG2 . ILE A 1 496 ? 120.923 88.689  81.919  1.00 93.65  ? 496 ILE A CG2 1 
ATOM   3621 C  CD1 . ILE A 1 496 ? 120.006 88.560  84.797  1.00 93.65  ? 496 ILE A CD1 1 
ATOM   3622 N  N   . GLY A 1 497 ? 123.985 88.504  81.103  1.00 93.74  ? 497 GLY A N   1 
ATOM   3623 C  CA  . GLY A 1 497 ? 124.836 87.403  80.703  1.00 93.74  ? 497 GLY A CA  1 
ATOM   3624 C  C   . GLY A 1 497 ? 124.106 86.199  80.143  1.00 93.74  ? 497 GLY A C   1 
ATOM   3625 O  O   . GLY A 1 497 ? 124.758 85.313  79.574  1.00 93.74  ? 497 GLY A O   1 
ATOM   3626 N  N   . TYR A 1 498 ? 122.783 86.131  80.283  1.00 93.42  ? 498 TYR A N   1 
ATOM   3627 C  CA  . TYR A 1 498 ? 122.030 85.006  79.745  1.00 93.42  ? 498 TYR A CA  1 
ATOM   3628 C  C   . TYR A 1 498 ? 120.601 85.443  79.451  1.00 93.42  ? 498 TYR A C   1 
ATOM   3629 O  O   . TYR A 1 498 ? 120.133 86.473  79.937  1.00 93.42  ? 498 TYR A O   1 
ATOM   3630 C  CB  . TYR A 1 498 ? 122.052 83.807  80.703  1.00 93.42  ? 498 TYR A CB  1 
ATOM   3631 C  CG  . TYR A 1 498 ? 121.550 84.101  82.098  1.00 93.42  ? 498 TYR A CG  1 
ATOM   3632 C  CD1 . TYR A 1 498 ? 120.205 83.971  82.416  1.00 93.42  ? 498 TYR A CD1 1 
ATOM   3633 C  CD2 . TYR A 1 498 ? 122.420 84.511  83.098  1.00 93.42  ? 498 TYR A CD2 1 
ATOM   3634 C  CE1 . TYR A 1 498 ? 119.743 84.235  83.688  1.00 93.42  ? 498 TYR A CE1 1 
ATOM   3635 C  CE2 . TYR A 1 498 ? 121.966 84.781  84.373  1.00 93.42  ? 498 TYR A CE2 1 
ATOM   3636 C  CZ  . TYR A 1 498 ? 120.627 84.641  84.662  1.00 93.42  ? 498 TYR A CZ  1 
ATOM   3637 O  OH  . TYR A 1 498 ? 120.169 84.906  85.931  1.00 93.42  ? 498 TYR A OH  1 
ATOM   3638 N  N   . ARG A 1 499 ? 119.916 84.651  78.630  1.00 92.91  ? 499 ARG A N   1 
ATOM   3639 C  CA  . ARG A 1 499 ? 118.526 84.940  78.289  1.00 92.91  ? 499 ARG A CA  1 
ATOM   3640 C  C   . ARG A 1 499 ? 117.595 84.420  79.379  1.00 92.91  ? 499 ARG A C   1 
ATOM   3641 O  O   . ARG A 1 499 ? 117.630 83.228  79.698  1.00 92.91  ? 499 ARG A O   1 
ATOM   3642 C  CB  . ARG A 1 499 ? 118.157 84.315  76.947  1.00 92.91  ? 499 ARG A CB  1 
ATOM   3643 C  CG  . ARG A 1 499 ? 116.718 84.571  76.533  1.00 92.91  ? 499 ARG A CG  1 
ATOM   3644 C  CD  . ARG A 1 499 ? 116.455 86.046  76.278  1.00 92.91  ? 499 ARG A CD  1 
ATOM   3645 N  NE  . ARG A 1 499 ? 117.255 86.578  75.183  1.00 92.91  ? 499 ARG A NE  1 
ATOM   3646 C  CZ  . ARG A 1 499 ? 116.909 86.503  73.906  1.00 92.91  ? 499 ARG A CZ  1 
ATOM   3647 N  NH1 . ARG A 1 499 ? 115.777 85.933  73.530  1.00 92.91  ? 499 ARG A NH1 1 
ATOM   3648 N  NH2 . ARG A 1 499 ? 117.717 87.018  72.983  1.00 92.91  ? 499 ARG A NH2 1 
ATOM   3649 N  N   . PRO A 1 500 ? 116.760 85.273  79.968  1.00 88.82  ? 500 PRO A N   1 
ATOM   3650 C  CA  . PRO A 1 500 ? 115.822 84.802  80.992  1.00 88.82  ? 500 PRO A CA  1 
ATOM   3651 C  C   . PRO A 1 500 ? 114.694 83.979  80.388  1.00 88.82  ? 500 PRO A C   1 
ATOM   3652 O  O   . PRO A 1 500 ? 114.542 83.870  79.170  1.00 88.82  ? 500 PRO A O   1 
ATOM   3653 C  CB  . PRO A 1 500 ? 115.286 86.100  81.609  1.00 88.82  ? 500 PRO A CB  1 
ATOM   3654 C  CG  . PRO A 1 500 ? 116.263 87.161  81.201  1.00 88.82  ? 500 PRO A CG  1 
ATOM   3655 C  CD  . PRO A 1 500 ? 116.752 86.739  79.855  1.00 88.82  ? 500 PRO A CD  1 
ATOM   3656 N  N   . GLY A 1 501 ? 113.893 83.392  81.273  1.00 89.14  ? 501 GLY A N   1 
ATOM   3657 C  CA  . GLY A 1 501 ? 112.727 82.646  80.867  1.00 89.14  ? 501 GLY A CA  1 
ATOM   3658 C  C   . GLY A 1 501 ? 111.626 83.550  80.348  1.00 89.14  ? 501 GLY A C   1 
ATOM   3659 O  O   . GLY A 1 501 ? 111.606 84.756  80.614  1.00 89.14  ? 501 GLY A O   1 
ATOM   3660 N  N   . PRO A 1 502 ? 110.682 82.982  79.595  1.00 85.20  ? 502 PRO A N   1 
ATOM   3661 C  CA  . PRO A 1 502 ? 109.606 83.791  79.009  1.00 85.20  ? 502 PRO A CA  1 
ATOM   3662 C  C   . PRO A 1 502 ? 108.478 84.130  79.971  1.00 85.20  ? 502 PRO A C   1 
ATOM   3663 O  O   . PRO A 1 502 ? 107.418 84.573  79.517  1.00 85.20  ? 502 PRO A O   1 
ATOM   3664 C  CB  . PRO A 1 502 ? 109.100 82.895  77.872  1.00 85.20  ? 502 PRO A CB  1 
ATOM   3665 C  CG  . PRO A 1 502 ? 109.317 81.514  78.386  1.00 85.20  ? 502 PRO A CG  1 
ATOM   3666 C  CD  . PRO A 1 502 ? 110.574 81.562  79.220  1.00 85.20  ? 502 PRO A CD  1 
ATOM   3667 N  N   . TRP A 1 503 ? 108.671 83.936  81.276  1.00 83.49  ? 503 TRP A N   1 
ATOM   3668 C  CA  . TRP A 1 503 ? 107.593 84.147  82.237  1.00 83.49  ? 503 TRP A CA  1 
ATOM   3669 C  C   . TRP A 1 503 ? 107.157 85.607  82.289  1.00 83.49  ? 503 TRP A C   1 
ATOM   3670 O  O   . TRP A 1 503 ? 105.959 85.913  82.225  1.00 83.49  ? 503 TRP A O   1 
ATOM   3671 C  CB  . TRP A 1 503 ? 108.039 83.655  83.613  1.00 83.49  ? 503 TRP A CB  1 
ATOM   3672 C  CG  . TRP A 1 503 ? 107.053 83.884  84.703  1.00 83.49  ? 503 TRP A CG  1 
ATOM   3673 C  CD1 . TRP A 1 503 ? 105.747 83.497  84.723  1.00 83.49  ? 503 TRP A CD1 1 
ATOM   3674 C  CD2 . TRP A 1 503 ? 107.311 84.490  85.974  1.00 83.49  ? 503 TRP A CD2 1 
ATOM   3675 N  NE1 . TRP A 1 503 ? 105.163 83.861  85.911  1.00 83.49  ? 503 TRP A NE1 1 
ATOM   3676 C  CE2 . TRP A 1 503 ? 106.105 84.468  86.699  1.00 83.49  ? 503 TRP A CE2 1 
ATOM   3677 C  CE3 . TRP A 1 503 ? 108.442 85.061  86.564  1.00 83.49  ? 503 TRP A CE3 1 
ATOM   3678 C  CZ2 . TRP A 1 503 ? 105.997 84.994  87.984  1.00 83.49  ? 503 TRP A CZ2 1 
ATOM   3679 C  CZ3 . TRP A 1 503 ? 108.333 85.585  87.839  1.00 83.49  ? 503 TRP A CZ3 1 
ATOM   3680 C  CH2 . TRP A 1 503 ? 107.119 85.547  88.535  1.00 83.49  ? 503 TRP A CH2 1 
ATOM   3681 N  N   . MET A 1 504 ? 108.113 86.529  82.395  1.00 81.43  ? 504 MET A N   1 
ATOM   3682 C  CA  . MET A 1 504 ? 107.750 87.934  82.544  1.00 81.43  ? 504 MET A CA  1 
ATOM   3683 C  C   . MET A 1 504 ? 107.226 88.519  81.242  1.00 81.43  ? 504 MET A C   1 
ATOM   3684 O  O   . MET A 1 504 ? 106.410 89.448  81.257  1.00 81.43  ? 504 MET A O   1 
ATOM   3685 C  CB  . MET A 1 504 ? 108.940 88.736  83.062  1.00 81.43  ? 504 MET A CB  1 
ATOM   3686 C  CG  . MET A 1 504 ? 109.325 88.379  84.480  1.00 81.43  ? 504 MET A CG  1 
ATOM   3687 S  SD  . MET A 1 504 ? 110.728 89.323  85.076  1.00 81.43  ? 504 MET A SD  1 
ATOM   3688 C  CE  . MET A 1 504 ? 110.945 88.588  86.689  1.00 81.43  ? 504 MET A CE  1 
ATOM   3689 N  N   . LYS A 1 505 ? 107.676 87.991  80.104  1.00 78.72  ? 505 LYS A N   1 
ATOM   3690 C  CA  . LYS A 1 505 ? 107.152 88.451  78.824  1.00 78.72  ? 505 LYS A CA  1 
ATOM   3691 C  C   . LYS A 1 505 ? 105.649 88.214  78.741  1.00 78.72  ? 505 LYS A C   1 
ATOM   3692 O  O   . LYS A 1 505 ? 104.870 89.135  78.467  1.00 78.72  ? 505 LYS A O   1 
ATOM   3693 C  CB  . LYS A 1 505 ? 107.879 87.745  77.681  1.00 78.72  ? 505 LYS A CB  1 
ATOM   3694 C  CG  . LYS A 1 505 ? 107.322 88.056  76.308  1.00 78.72  ? 505 LYS A CG  1 
ATOM   3695 C  CD  . LYS A 1 505 ? 107.565 86.907  75.348  1.00 78.72  ? 505 LYS A CD  1 
ATOM   3696 C  CE  . LYS A 1 505 ? 109.035 86.535  75.301  1.00 78.72  ? 505 LYS A CE  1 
ATOM   3697 N  NZ  . LYS A 1 505 ? 109.815 87.493  74.472  1.00 78.72  ? 505 LYS A NZ  1 
ATOM   3698 N  N   . TYR A 1 506 ? 105.222 86.979  79.008  1.00 77.49  ? 506 TYR A N   1 
ATOM   3699 C  CA  . TYR A 1 506 ? 103.802 86.661  78.982  1.00 77.49  ? 506 TYR A CA  1 
ATOM   3700 C  C   . TYR A 1 506 ? 103.053 87.271  80.156  1.00 77.49  ? 506 TYR A C   1 
ATOM   3701 O  O   . TYR A 1 506 ? 101.839 87.468  80.059  1.00 77.49  ? 506 TYR A O   1 
ATOM   3702 C  CB  . TYR A 1 506 ? 103.600 85.147  78.957  1.00 77.49  ? 506 TYR A CB  1 
ATOM   3703 C  CG  . TYR A 1 506 ? 104.038 84.509  77.661  1.00 77.49  ? 506 TYR A CG  1 
ATOM   3704 C  CD1 . TYR A 1 506 ? 104.077 85.243  76.484  1.00 77.49  ? 506 TYR A CD1 1 
ATOM   3705 C  CD2 . TYR A 1 506 ? 104.411 83.174  77.612  1.00 77.49  ? 506 TYR A CD2 1 
ATOM   3706 C  CE1 . TYR A 1 506 ? 104.479 84.667  75.296  1.00 77.49  ? 506 TYR A CE1 1 
ATOM   3707 C  CE2 . TYR A 1 506 ? 104.813 82.588  76.428  1.00 77.49  ? 506 TYR A CE2 1 
ATOM   3708 C  CZ  . TYR A 1 506 ? 104.845 83.340  75.273  1.00 77.49  ? 506 TYR A CZ  1 
ATOM   3709 O  OH  . TYR A 1 506 ? 105.245 82.761  74.091  1.00 77.49  ? 506 TYR A OH  1 
ATOM   3710 N  N   . SER A 1 507 ? 103.736 87.570  81.262  1.00 74.68  ? 507 SER A N   1 
ATOM   3711 C  CA  . SER A 1 507 ? 103.091 88.342  82.319  1.00 74.68  ? 507 SER A CA  1 
ATOM   3712 C  C   . SER A 1 507 ? 102.705 89.723  81.808  1.00 74.68  ? 507 SER A C   1 
ATOM   3713 O  O   . SER A 1 507 ? 101.516 90.050  81.712  1.00 74.68  ? 507 SER A O   1 
ATOM   3714 C  CB  . SER A 1 507 ? 104.009 88.448  83.535  1.00 74.68  ? 507 SER A CB  1 
ATOM   3715 O  OG  . SER A 1 507 ? 103.991 87.250  84.288  1.00 74.68  ? 507 SER A OG  1 
ATOM   3716 N  N   . TRP A 1 508 ? 103.704 90.513  81.401  1.00 73.12  ? 508 TRP A N   1 
ATOM   3717 C  CA  . TRP A 1 508 ? 103.456 91.871  80.929  1.00 73.12  ? 508 TRP A CA  1 
ATOM   3718 C  C   . TRP A 1 508 ? 102.475 91.893  79.764  1.00 73.12  ? 508 TRP A C   1 
ATOM   3719 O  O   . TRP A 1 508 ? 101.647 92.805  79.662  1.00 73.12  ? 508 TRP A O   1 
ATOM   3720 C  CB  . TRP A 1 508 ? 104.767 92.536  80.504  1.00 73.12  ? 508 TRP A CB  1 
ATOM   3721 C  CG  . TRP A 1 508 ? 105.890 92.452  81.495  1.00 73.12  ? 508 TRP A CG  1 
ATOM   3722 C  CD1 . TRP A 1 508 ? 105.790 92.369  82.851  1.00 73.12  ? 508 TRP A CD1 1 
ATOM   3723 C  CD2 . TRP A 1 508 ? 107.292 92.452  81.195  1.00 73.12  ? 508 TRP A CD2 1 
ATOM   3724 N  NE1 . TRP A 1 508 ? 107.041 92.315  83.415  1.00 73.12  ? 508 TRP A NE1 1 
ATOM   3725 C  CE2 . TRP A 1 508 ? 107.980 92.362  82.419  1.00 73.12  ? 508 TRP A CE2 1 
ATOM   3726 C  CE3 . TRP A 1 508 ? 108.031 92.516  80.009  1.00 73.12  ? 508 TRP A CE3 1 
ATOM   3727 C  CZ2 . TRP A 1 508 ? 109.370 92.336  82.493  1.00 73.12  ? 508 TRP A CZ2 1 
ATOM   3728 C  CZ3 . TRP A 1 508 ? 109.410 92.491  80.085  1.00 73.12  ? 508 TRP A CZ3 1 
ATOM   3729 C  CH2 . TRP A 1 508 ? 110.065 92.402  81.317  1.00 73.12  ? 508 TRP A CH2 1 
ATOM   3730 N  N   . ALA A 1 509 ? 102.557 90.906  78.865  1.00 71.58  ? 509 ALA A N   1 
ATOM   3731 C  CA  . ALA A 1 509 ? 101.769 90.972  77.638  1.00 71.58  ? 509 ALA A CA  1 
ATOM   3732 C  C   . ALA A 1 509 ? 100.274 90.849  77.909  1.00 71.58  ? 509 ALA A C   1 
ATOM   3733 O  O   . ALA A 1 509 ? 99.485  91.656  77.406  1.00 71.58  ? 509 ALA A O   1 
ATOM   3734 C  CB  . ALA A 1 509 ? 102.226 89.889  76.663  1.00 71.58  ? 509 ALA A CB  1 
ATOM   3735 N  N   . VAL A 1 510 ? 99.858  89.846  78.686  1.00 69.67  ? 510 VAL A N   1 
ATOM   3736 C  CA  . VAL A 1 510 ? 98.448  89.521  78.840  1.00 69.67  ? 510 VAL A CA  1 
ATOM   3737 C  C   . VAL A 1 510 ? 97.990  89.567  80.293  1.00 69.67  ? 510 VAL A C   1 
ATOM   3738 O  O   . VAL A 1 510 ? 96.896  90.062  80.581  1.00 69.67  ? 510 VAL A O   1 
ATOM   3739 C  CB  . VAL A 1 510 ? 98.108  88.150  78.206  1.00 69.67  ? 510 VAL A CB  1 
ATOM   3740 C  CG1 . VAL A 1 510 ? 98.308  88.197  76.701  1.00 69.67  ? 510 VAL A CG1 1 
ATOM   3741 C  CG2 . VAL A 1 510 ? 98.939  87.037  78.815  1.00 69.67  ? 510 VAL A CG2 1 
ATOM   3742 N  N   . ILE A 1 511 ? 98.793  89.050  81.226  1.00 66.81  ? 511 ILE A N   1 
ATOM   3743 C  CA  . ILE A 1 511 ? 98.244  88.692  82.531  1.00 66.81  ? 511 ILE A CA  1 
ATOM   3744 C  C   . ILE A 1 511 ? 97.865  89.934  83.327  1.00 66.81  ? 511 ILE A C   1 
ATOM   3745 O  O   . ILE A 1 511 ? 96.803  89.980  83.957  1.00 66.81  ? 511 ILE A O   1 
ATOM   3746 C  CB  . ILE A 1 511 ? 99.234  87.800  83.299  1.00 66.81  ? 511 ILE A CB  1 
ATOM   3747 C  CG1 . ILE A 1 511 ? 99.480  86.504  82.528  1.00 66.81  ? 511 ILE A CG1 1 
ATOM   3748 C  CG2 . ILE A 1 511 ? 98.707  87.491  84.688  1.00 66.81  ? 511 ILE A CG2 1 
ATOM   3749 C  CD1 . ILE A 1 511 ? 100.485 85.589  83.179  1.00 66.81  ? 511 ILE A CD1 1 
ATOM   3750 N  N   . THR A 1 512 ? 98.711  90.955  83.313  1.00 67.38  ? 512 THR A N   1 
ATOM   3751 C  CA  . THR A 1 512 ? 98.454  92.142  84.120  1.00 67.38  ? 512 THR A CA  1 
ATOM   3752 C  C   . THR A 1 512 ? 97.381  93.042  83.503  1.00 67.38  ? 512 THR A C   1 
ATOM   3753 O  O   . THR A 1 512 ? 96.476  93.480  84.227  1.00 67.38  ? 512 THR A O   1 
ATOM   3754 C  CB  . THR A 1 512 ? 99.753  92.921  84.350  1.00 67.38  ? 512 THR A CB  1 
ATOM   3755 O  OG1 . THR A 1 512 ? 100.658 92.118  85.116  1.00 67.38  ? 512 THR A OG1 1 
ATOM   3756 C  CG2 . THR A 1 512 ? 99.479  94.213  85.101  1.00 67.38  ? 512 THR A CG2 1 
ATOM   3757 N  N   . PRO A 1 513 ? 97.434  93.357  82.197  1.00 69.89  ? 513 PRO A N   1 
ATOM   3758 C  CA  . PRO A 1 513 ? 96.357  94.184  81.623  1.00 69.89  ? 513 PRO A CA  1 
ATOM   3759 C  C   . PRO A 1 513 ? 94.968  93.591  81.792  1.00 69.89  ? 513 PRO A C   1 
ATOM   3760 O  O   . PRO A 1 513 ? 94.011  94.335  82.044  1.00 69.89  ? 513 PRO A O   1 
ATOM   3761 C  CB  . PRO A 1 513 ? 96.751  94.286  80.144  1.00 69.89  ? 513 PRO A CB  1 
ATOM   3762 C  CG  . PRO A 1 513 ? 98.209  94.132  80.141  1.00 69.89  ? 513 PRO A CG  1 
ATOM   3763 C  CD  . PRO A 1 513 ? 98.503  93.126  81.207  1.00 69.89  ? 513 PRO A CD  1 
ATOM   3764 N  N   . VAL A 1 514 ? 94.829  92.271  81.665  1.00 69.33  ? 514 VAL A N   1 
ATOM   3765 C  CA  . VAL A 1 514 ? 93.515  91.648  81.800  1.00 69.33  ? 514 VAL A CA  1 
ATOM   3766 C  C   . VAL A 1 514 ? 92.967  91.866  83.204  1.00 69.33  ? 514 VAL A C   1 
ATOM   3767 O  O   . VAL A 1 514 ? 91.812  92.270  83.381  1.00 69.33  ? 514 VAL A O   1 
ATOM   3768 C  CB  . VAL A 1 514 ? 93.589  90.152  81.446  1.00 69.33  ? 514 VAL A CB  1 
ATOM   3769 C  CG1 . VAL A 1 514 ? 92.369  89.420  81.971  1.00 69.33  ? 514 VAL A CG1 1 
ATOM   3770 C  CG2 . VAL A 1 514 ? 93.702  89.972  79.944  1.00 69.33  ? 514 VAL A CG2 1 
ATOM   3771 N  N   . LEU A 1 515 ? 93.793  91.618  84.223  1.00 70.61  ? 515 LEU A N   1 
ATOM   3772 C  CA  . LEU A 1 515 ? 93.348  91.815  85.600  1.00 70.61  ? 515 LEU A CA  1 
ATOM   3773 C  C   . LEU A 1 515 ? 93.030  93.279  85.876  1.00 70.61  ? 515 LEU A C   1 
ATOM   3774 O  O   . LEU A 1 515 ? 92.019  93.594  86.518  1.00 70.61  ? 515 LEU A O   1 
ATOM   3775 C  CB  . LEU A 1 515 ? 94.414  91.311  86.573  1.00 70.61  ? 515 LEU A CB  1 
ATOM   3776 C  CG  . LEU A 1 515 ? 94.651  89.804  86.659  1.00 70.61  ? 515 LEU A CG  1 
ATOM   3777 C  CD1 . LEU A 1 515 ? 95.995  89.516  87.303  1.00 70.61  ? 515 LEU A CD1 1 
ATOM   3778 C  CD2 . LEU A 1 515 ? 93.535  89.132  87.436  1.00 70.61  ? 515 LEU A CD2 1 
ATOM   3779 N  N   . CYS A 1 516 ? 93.882  94.189  85.395  1.00 74.15  ? 516 CYS A N   1 
ATOM   3780 C  CA  . CYS A 1 516 ? 93.672  95.610  85.643  1.00 74.15  ? 516 CYS A CA  1 
ATOM   3781 C  C   . CYS A 1 516 ? 92.399  96.135  84.994  1.00 74.15  ? 516 CYS A C   1 
ATOM   3782 O  O   . CYS A 1 516 ? 91.698  96.945  85.608  1.00 74.15  ? 516 CYS A O   1 
ATOM   3783 C  CB  . CYS A 1 516 ? 94.877  96.414  85.155  1.00 74.15  ? 516 CYS A CB  1 
ATOM   3784 S  SG  . CYS A 1 516 ? 96.301  96.361  86.265  1.00 74.15  ? 516 CYS A SG  1 
ATOM   3785 N  N   . VAL A 1 517 ? 92.086  95.705  83.775  1.00 73.35  ? 517 VAL A N   1 
ATOM   3786 C  CA  . VAL A 1 517 ? 90.839  96.113  83.133  1.00 73.35  ? 517 VAL A CA  1 
ATOM   3787 C  C   . VAL A 1 517 ? 89.634  95.450  83.788  1.00 73.35  ? 517 VAL A C   1 
ATOM   3788 O  O   . VAL A 1 517 ? 88.594  96.090  83.983  1.00 73.35  ? 517 VAL A O   1 
ATOM   3789 C  CB  . VAL A 1 517 ? 90.903  95.808  81.624  1.00 73.35  ? 517 VAL A CB  1 
ATOM   3790 C  CG1 . VAL A 1 517 ? 89.534  95.959  80.991  1.00 73.35  ? 517 VAL A CG1 1 
ATOM   3791 C  CG2 . VAL A 1 517 ? 91.901  96.726  80.948  1.00 73.35  ? 517 VAL A CG2 1 
ATOM   3792 N  N   . GLY A 1 518 ? 89.752  94.166  84.133  1.00 74.71  ? 518 GLY A N   1 
ATOM   3793 C  CA  . GLY A 1 518 ? 88.630  93.466  84.730  1.00 74.71  ? 518 GLY A CA  1 
ATOM   3794 C  C   . GLY A 1 518 ? 88.218  94.054  86.062  1.00 74.71  ? 518 GLY A C   1 
ATOM   3795 O  O   . GLY A 1 518 ? 87.031  94.249  86.324  1.00 74.71  ? 518 GLY A O   1 
ATOM   3796 N  N   . CYS A 1 519 ? 89.195  94.353  86.924  1.00 78.96  ? 519 CYS A N   1 
ATOM   3797 C  CA  . CYS A 1 519 ? 88.864  94.927  88.225  1.00 78.96  ? 519 CYS A CA  1 
ATOM   3798 C  C   . CYS A 1 519 ? 88.197  96.289  88.078  1.00 78.96  ? 519 CYS A C   1 
ATOM   3799 O  O   . CYS A 1 519 ? 87.205  96.579  88.757  1.00 78.96  ? 519 CYS A O   1 
ATOM   3800 C  CB  . CYS A 1 519 ? 90.119  95.033  89.091  1.00 78.96  ? 519 CYS A CB  1 
ATOM   3801 S  SG  . CYS A 1 519 ? 90.600  93.482  89.884  1.00 78.96  ? 519 CYS A SG  1 
ATOM   3802 N  N   . PHE A 1 520 ? 88.715  97.130  87.183  1.00 78.45  ? 520 PHE A N   1 
ATOM   3803 C  CA  . PHE A 1 520 ? 88.152  98.464  86.990  1.00 78.45  ? 520 PHE A CA  1 
ATOM   3804 C  C   . PHE A 1 520 ? 86.718  98.392  86.474  1.00 78.45  ? 520 PHE A C   1 
ATOM   3805 O  O   . PHE A 1 520 ? 85.815  99.045  87.016  1.00 78.45  ? 520 PHE A O   1 
ATOM   3806 C  CB  . PHE A 1 520 ? 89.045  99.253  86.032  1.00 78.45  ? 520 PHE A CB  1 
ATOM   3807 C  CG  . PHE A 1 520 ? 88.531  100.619 85.698  1.00 78.45  ? 520 PHE A CG  1 
ATOM   3808 C  CD1 . PHE A 1 520 ? 88.624  101.650 86.613  1.00 78.45  ? 520 PHE A CD1 1 
ATOM   3809 C  CD2 . PHE A 1 520 ? 87.984  100.883 84.455  1.00 78.45  ? 520 PHE A CD2 1 
ATOM   3810 C  CE1 . PHE A 1 520 ? 88.162  102.914 86.304  1.00 78.45  ? 520 PHE A CE1 1 
ATOM   3811 C  CE2 . PHE A 1 520 ? 87.524  102.145 84.139  1.00 78.45  ? 520 PHE A CE2 1 
ATOM   3812 C  CZ  . PHE A 1 520 ? 87.613  103.162 85.066  1.00 78.45  ? 520 PHE A CZ  1 
ATOM   3813 N  N   . ILE A 1 521 ? 86.486  97.587  85.432  1.00 78.14  ? 521 ILE A N   1 
ATOM   3814 C  CA  . ILE A 1 521 ? 85.139  97.462  84.881  1.00 78.14  ? 521 ILE A CA  1 
ATOM   3815 C  C   . ILE A 1 521 ? 84.191  96.856  85.909  1.00 78.14  ? 521 ILE A C   1 
ATOM   3816 O  O   . ILE A 1 521 ? 83.047  97.301  86.061  1.00 78.14  ? 521 ILE A O   1 
ATOM   3817 C  CB  . ILE A 1 521 ? 85.169  96.642  83.578  1.00 78.14  ? 521 ILE A CB  1 
ATOM   3818 C  CG1 . ILE A 1 521 ? 85.675  97.504  82.421  1.00 78.14  ? 521 ILE A CG1 1 
ATOM   3819 C  CG2 . ILE A 1 521 ? 83.793  96.083  83.256  1.00 78.14  ? 521 ILE A CG2 1 
ATOM   3820 C  CD1 . ILE A 1 521 ? 85.800  96.756  81.116  1.00 78.14  ? 521 ILE A CD1 1 
ATOM   3821 N  N   . PHE A 1 522 ? 84.650  95.835  86.634  1.00 83.06  ? 522 PHE A N   1 
ATOM   3822 C  CA  . PHE A 1 522 ? 83.803  95.159  87.607  1.00 83.06  ? 522 PHE A CA  1 
ATOM   3823 C  C   . PHE A 1 522 ? 83.433  96.090  88.754  1.00 83.06  ? 522 PHE A C   1 
ATOM   3824 O  O   . PHE A 1 522 ? 82.324  96.018  89.296  1.00 83.06  ? 522 PHE A O   1 
ATOM   3825 C  CB  . PHE A 1 522 ? 84.524  93.907  88.107  1.00 83.06  ? 522 PHE A CB  1 
ATOM   3826 C  CG  . PHE A 1 522 ? 83.631  92.912  88.779  1.00 83.06  ? 522 PHE A CG  1 
ATOM   3827 C  CD1 . PHE A 1 522 ? 82.554  92.364  88.105  1.00 83.06  ? 522 PHE A CD1 1 
ATOM   3828 C  CD2 . PHE A 1 522 ? 83.908  92.469  90.059  1.00 83.06  ? 522 PHE A CD2 1 
ATOM   3829 C  CE1 . PHE A 1 522 ? 81.738  91.432  88.716  1.00 83.06  ? 522 PHE A CE1 1 
ATOM   3830 C  CE2 . PHE A 1 522 ? 83.103  91.530  90.669  1.00 83.06  ? 522 PHE A CE2 1 
ATOM   3831 C  CZ  . PHE A 1 522 ? 82.015  91.013  90.000  1.00 83.06  ? 522 PHE A CZ  1 
ATOM   3832 N  N   . SER A 1 523 ? 84.355  96.975  89.143  1.00 83.02  ? 523 SER A N   1 
ATOM   3833 C  CA  . SER A 1 523 ? 84.037  97.958  90.174  1.00 83.02  ? 523 SER A CA  1 
ATOM   3834 C  C   . SER A 1 523 ? 83.046  98.995  89.661  1.00 83.02  ? 523 SER A C   1 
ATOM   3835 O  O   . SER A 1 523 ? 82.125  99.390  90.384  1.00 83.02  ? 523 SER A O   1 
ATOM   3836 C  CB  . SER A 1 523 ? 85.314  98.634  90.671  1.00 83.02  ? 523 SER A CB  1 
ATOM   3837 O  OG  . SER A 1 523 ? 86.075  99.147  89.593  1.00 83.02  ? 523 SER A OG  1 
ATOM   3838 N  N   . LEU A 1 524 ? 83.219  99.456  88.418  1.00 83.24  ? 524 LEU A N   1 
ATOM   3839 C  CA  . LEU A 1 524 ? 82.295  100.453 87.880  1.00 83.24  ? 524 LEU A CA  1 
ATOM   3840 C  C   . LEU A 1 524 ? 80.887  99.892  87.724  1.00 83.24  ? 524 LEU A C   1 
ATOM   3841 O  O   . LEU A 1 524 ? 79.902  100.601 87.963  1.00 83.24  ? 524 LEU A O   1 
ATOM   3842 C  CB  . LEU A 1 524 ? 82.792  100.987 86.539  1.00 83.24  ? 524 LEU A CB  1 
ATOM   3843 C  CG  . LEU A 1 524 ? 83.960  101.968 86.564  1.00 83.24  ? 524 LEU A CG  1 
ATOM   3844 C  CD1 . LEU A 1 524 ? 84.216  102.476 85.160  1.00 83.24  ? 524 LEU A CD1 1 
ATOM   3845 C  CD2 . LEU A 1 524 ? 83.680  103.114 87.517  1.00 83.24  ? 524 LEU A CD2 1 
ATOM   3846 N  N   . VAL A 1 525 ? 80.768  98.632  87.299  1.00 85.33  ? 525 VAL A N   1 
ATOM   3847 C  CA  . VAL A 1 525 ? 79.449  98.045  87.068  1.00 85.33  ? 525 VAL A CA  1 
ATOM   3848 C  C   . VAL A 1 525 ? 78.666  97.957  88.373  1.00 85.33  ? 525 VAL A C   1 
ATOM   3849 O  O   . VAL A 1 525 ? 77.479  98.300  88.431  1.00 85.33  ? 525 VAL A O   1 
ATOM   3850 C  CB  . VAL A 1 525 ? 79.585  96.669  86.391  1.00 85.33  ? 525 VAL A CB  1 
ATOM   3851 C  CG1 . VAL A 1 525 ? 78.312  95.860  86.563  1.00 85.33  ? 525 VAL A CG1 1 
ATOM   3852 C  CG2 . VAL A 1 525 ? 79.910  96.839  84.918  1.00 85.33  ? 525 VAL A CG2 1 
ATOM   3853 N  N   . LYS A 1 526 ? 79.317  97.504  89.439  1.00 89.12  ? 526 LYS A N   1 
ATOM   3854 C  CA  . LYS A 1 526 ? 78.700  97.382  90.758  1.00 89.12  ? 526 LYS A CA  1 
ATOM   3855 C  C   . LYS A 1 526 ? 79.374  98.395  91.681  1.00 89.12  ? 526 LYS A C   1 
ATOM   3856 O  O   . LYS A 1 526 ? 80.447  98.139  92.228  1.00 89.12  ? 526 LYS A O   1 
ATOM   3857 C  CB  . LYS A 1 526 ? 78.832  95.961  91.293  1.00 89.12  ? 526 LYS A CB  1 
ATOM   3858 C  CG  . LYS A 1 526 ? 78.040  94.932  90.511  1.00 89.12  ? 526 LYS A CG  1 
ATOM   3859 C  CD  . LYS A 1 526 ? 78.326  93.525  91.005  1.00 89.12  ? 526 LYS A CD  1 
ATOM   3860 C  CE  . LYS A 1 526 ? 77.710  93.286  92.373  1.00 89.12  ? 526 LYS A CE  1 
ATOM   3861 N  NZ  . LYS A 1 526 ? 77.875  91.875  92.816  1.00 89.12  ? 526 LYS A NZ  1 
ATOM   3862 N  N   . TYR A 1 527 ? 78.731  99.547  91.857  1.00 85.40  ? 527 TYR A N   1 
ATOM   3863 C  CA  . TYR A 1 527 ? 79.304  100.644 92.626  1.00 85.40  ? 527 TYR A CA  1 
ATOM   3864 C  C   . TYR A 1 527 ? 78.759  100.632 94.048  1.00 85.40  ? 527 TYR A C   1 
ATOM   3865 O  O   . TYR A 1 527 ? 77.546  100.531 94.255  1.00 85.40  ? 527 TYR A O   1 
ATOM   3866 C  CB  . TYR A 1 527 ? 79.004  101.983 91.950  1.00 85.40  ? 527 TYR A CB  1 
ATOM   3867 C  CG  . TYR A 1 527 ? 79.747  103.165 92.539  1.00 85.40  ? 527 TYR A CG  1 
ATOM   3868 C  CD1 . TYR A 1 527 ? 79.310  103.779 93.706  1.00 85.40  ? 527 TYR A CD1 1 
ATOM   3869 C  CD2 . TYR A 1 527 ? 80.887  103.665 91.925  1.00 85.40  ? 527 TYR A CD2 1 
ATOM   3870 C  CE1 . TYR A 1 527 ? 79.987  104.854 94.245  1.00 85.40  ? 527 TYR A CE1 1 
ATOM   3871 C  CE2 . TYR A 1 527 ? 81.570  104.741 92.456  1.00 85.40  ? 527 TYR A CE2 1 
ATOM   3872 C  CZ  . TYR A 1 527 ? 81.115  105.332 93.616  1.00 85.40  ? 527 TYR A CZ  1 
ATOM   3873 O  OH  . TYR A 1 527 ? 81.791  106.405 94.150  1.00 85.40  ? 527 TYR A OH  1 
ATOM   3874 N  N   . VAL A 1 528 ? 79.660  100.732 95.022  1.00 85.02  ? 528 VAL A N   1 
ATOM   3875 C  CA  . VAL A 1 528 ? 79.289  100.823 96.432  1.00 85.02  ? 528 VAL A CA  1 
ATOM   3876 C  C   . VAL A 1 528 ? 80.065  101.971 97.068  1.00 85.02  ? 528 VAL A C   1 
ATOM   3877 O  O   . VAL A 1 528 ? 81.296  102.031 96.940  1.00 85.02  ? 528 VAL A O   1 
ATOM   3878 C  CB  . VAL A 1 528 ? 79.551  99.498  97.166  1.00 85.02  ? 528 VAL A CB  1 
ATOM   3879 C  CG1 . VAL A 1 528 ? 79.504  99.704  98.668  1.00 85.02  ? 528 VAL A CG1 1 
ATOM   3880 C  CG2 . VAL A 1 528 ? 78.537  98.452  96.743  1.00 85.02  ? 528 VAL A CG2 1 
ATOM   3881 N  N   . PRO A 1 529 ? 79.398  102.905 97.744  1.00 79.20  ? 529 PRO A N   1 
ATOM   3882 C  CA  . PRO A 1 529 ? 80.115  104.033 98.350  1.00 79.20  ? 529 PRO A CA  1 
ATOM   3883 C  C   . PRO A 1 529 ? 80.972  103.609 99.534  1.00 79.20  ? 529 PRO A C   1 
ATOM   3884 O  O   . PRO A 1 529 ? 80.682  102.633 100.229 1.00 79.20  ? 529 PRO A O   1 
ATOM   3885 C  CB  . PRO A 1 529 ? 78.985  104.969 98.792  1.00 79.20  ? 529 PRO A CB  1 
ATOM   3886 C  CG  . PRO A 1 529 ? 77.819  104.067 98.999  1.00 79.20  ? 529 PRO A CG  1 
ATOM   3887 C  CD  . PRO A 1 529 ? 77.943  102.997 97.954  1.00 79.20  ? 529 PRO A CD  1 
ATOM   3888 N  N   . LEU A 1 530 ? 82.041  104.371 99.756  1.00 72.00  ? 530 LEU A N   1 
ATOM   3889 C  CA  . LEU A 1 530 ? 82.927  104.137 100.889 1.00 72.00  ? 530 LEU A CA  1 
ATOM   3890 C  C   . LEU A 1 530 ? 82.238  104.493 102.200 1.00 72.00  ? 530 LEU A C   1 
ATOM   3891 O  O   . LEU A 1 530 ? 81.531  105.499 102.295 1.00 72.00  ? 530 LEU A O   1 
ATOM   3892 C  CB  . LEU A 1 530 ? 84.207  104.959 100.733 1.00 72.00  ? 530 LEU A CB  1 
ATOM   3893 C  CG  . LEU A 1 530 ? 85.104  105.135 101.962 1.00 72.00  ? 530 LEU A CG  1 
ATOM   3894 C  CD1 . LEU A 1 530 ? 85.695  103.809 102.416 1.00 72.00  ? 530 LEU A CD1 1 
ATOM   3895 C  CD2 . LEU A 1 530 ? 86.202  106.150 101.687 1.00 72.00  ? 530 LEU A CD2 1 
ATOM   3896 N  N   . THR A 1 531 ? 82.450  103.661 103.218 1.00 72.68  ? 531 THR A N   1 
ATOM   3897 C  CA  . THR A 1 531 ? 81.941  103.923 104.558 1.00 72.68  ? 531 THR A CA  1 
ATOM   3898 C  C   . THR A 1 531 ? 83.081  103.793 105.554 1.00 72.68  ? 531 THR A C   1 
ATOM   3899 O  O   . THR A 1 531 ? 83.752  102.758 105.593 1.00 72.68  ? 531 THR A O   1 
ATOM   3900 C  CB  . THR A 1 531 ? 80.816  102.951 104.934 1.00 72.68  ? 531 THR A CB  1 
ATOM   3901 O  OG1 . THR A 1 531 ? 81.295  101.605 104.844 1.00 72.68  ? 531 THR A OG1 1 
ATOM   3902 C  CG2 . THR A 1 531 ? 79.626  103.120 104.006 1.00 72.68  ? 531 THR A CG2 1 
ATOM   3903 N  N   . TYR A 1 532 ? 83.299  104.830 106.359 1.00 70.38  ? 532 TYR A N   1 
ATOM   3904 C  CA  . TYR A 1 532 ? 84.307  104.742 107.404 1.00 70.38  ? 532 TYR A CA  1 
ATOM   3905 C  C   . TYR A 1 532 ? 83.866  103.753 108.475 1.00 70.38  ? 532 TYR A C   1 
ATOM   3906 O  O   . TYR A 1 532 ? 82.716  103.759 108.920 1.00 70.38  ? 532 TYR A O   1 
ATOM   3907 C  CB  . TYR A 1 532 ? 84.571  106.110 108.033 1.00 70.38  ? 532 TYR A CB  1 
ATOM   3908 C  CG  . TYR A 1 532 ? 85.361  106.028 109.323 1.00 70.38  ? 532 TYR A CG  1 
ATOM   3909 C  CD1 . TYR A 1 532 ? 86.712  105.711 109.311 1.00 70.38  ? 532 TYR A CD1 1 
ATOM   3910 C  CD2 . TYR A 1 532 ? 84.754  106.251 110.551 1.00 70.38  ? 532 TYR A CD2 1 
ATOM   3911 C  CE1 . TYR A 1 532 ? 87.436  105.623 110.483 1.00 70.38  ? 532 TYR A CE1 1 
ATOM   3912 C  CE2 . TYR A 1 532 ? 85.470  106.168 111.728 1.00 70.38  ? 532 TYR A CE2 1 
ATOM   3913 C  CZ  . TYR A 1 532 ? 86.810  105.853 111.687 1.00 70.38  ? 532 TYR A CZ  1 
ATOM   3914 O  OH  . TYR A 1 532 ? 87.530  105.769 112.855 1.00 70.38  ? 532 TYR A OH  1 
ATOM   3915 N  N   . ASN A 1 533 ? 84.809  102.914 108.903 1.00 74.14  ? 533 ASN A N   1 
ATOM   3916 C  CA  . ASN A 1 533 ? 84.521  101.786 109.780 1.00 74.14  ? 533 ASN A CA  1 
ATOM   3917 C  C   . ASN A 1 533 ? 83.373  100.978 109.185 1.00 74.14  ? 533 ASN A C   1 
ATOM   3918 O  O   . ASN A 1 533 ? 83.468  100.521 108.041 1.00 74.14  ? 533 ASN A O   1 
ATOM   3919 C  CB  . ASN A 1 533 ? 84.204  102.267 111.197 1.00 74.14  ? 533 ASN A CB  1 
ATOM   3920 C  CG  . ASN A 1 533 ? 84.448  101.200 112.243 1.00 74.14  ? 533 ASN A CG  1 
ATOM   3921 O  OD1 . ASN A 1 533 ? 84.793  100.066 111.921 1.00 74.14  ? 533 ASN A OD1 1 
ATOM   3922 N  ND2 . ASN A 1 533 ? 84.287  101.566 113.508 1.00 74.14  ? 533 ASN A ND2 1 
ATOM   3923 N  N   . LYS A 1 534 ? 82.290  100.805 109.922 1.00 78.64  ? 534 LYS A N   1 
ATOM   3924 C  CA  . LYS A 1 534 ? 81.153  100.105 109.330 1.00 78.64  ? 534 LYS A CA  1 
ATOM   3925 C  C   . LYS A 1 534 ? 79.871  100.924 109.335 1.00 78.64  ? 534 LYS A C   1 
ATOM   3926 O  O   . LYS A 1 534 ? 79.139  100.907 108.343 1.00 78.64  ? 534 LYS A O   1 
ATOM   3927 C  CB  . LYS A 1 534 ? 80.919  98.766  110.047 1.00 78.64  ? 534 LYS A CB  1 
ATOM   3928 C  CG  . LYS A 1 534 ? 82.007  97.738  109.789 1.00 78.64  ? 534 LYS A CG  1 
ATOM   3929 C  CD  . LYS A 1 534 ? 81.681  96.403  110.431 1.00 78.64  ? 534 LYS A CD  1 
ATOM   3930 C  CE  . LYS A 1 534 ? 81.797  96.482  111.942 1.00 78.64  ? 534 LYS A CE  1 
ATOM   3931 N  NZ  . LYS A 1 534 ? 83.200  96.730  112.374 1.00 78.64  ? 534 LYS A NZ  1 
ATOM   3932 N  N   . THR A 1 535 ? 79.579  101.639 110.418 1.00 83.67  ? 535 THR A N   1 
ATOM   3933 C  CA  . THR A 1 535 ? 78.356  102.433 110.527 1.00 83.67  ? 535 THR A CA  1 
ATOM   3934 C  C   . THR A 1 535 ? 78.704  103.910 110.363 1.00 83.67  ? 535 THR A C   1 
ATOM   3935 O  O   . THR A 1 535 ? 78.858  104.643 111.340 1.00 83.67  ? 535 THR A O   1 
ATOM   3936 C  CB  . THR A 1 535 ? 77.660  102.169 111.856 1.00 83.67  ? 535 THR A CB  1 
ATOM   3937 O  OG1 . THR A 1 535 ? 78.517  102.568 112.933 1.00 83.67  ? 535 THR A OG1 1 
ATOM   3938 C  CG2 . THR A 1 535 ? 77.333  100.691 111.998 1.00 83.67  ? 535 THR A CG2 1 
ATOM   3939 N  N   . TYR A 1 536 ? 78.822  104.346 109.111 1.00 72.67  ? 536 TYR A N   1 
ATOM   3940 C  CA  . TYR A 1 536 ? 78.956  105.759 108.785 1.00 72.67  ? 536 TYR A CA  1 
ATOM   3941 C  C   . TYR A 1 536 ? 78.685  105.933 107.301 1.00 72.67  ? 536 TYR A C   1 
ATOM   3942 O  O   . TYR A 1 536 ? 79.054  105.088 106.484 1.00 72.67  ? 536 TYR A O   1 
ATOM   3943 C  CB  . TYR A 1 536 ? 80.340  106.314 109.138 1.00 72.67  ? 536 TYR A CB  1 
ATOM   3944 C  CG  . TYR A 1 536 ? 80.477  107.795 108.849 1.00 72.67  ? 536 TYR A CG  1 
ATOM   3945 C  CD1 . TYR A 1 536 ? 79.804  108.738 109.613 1.00 72.67  ? 536 TYR A CD1 1 
ATOM   3946 C  CD2 . TYR A 1 536 ? 81.256  108.248 107.793 1.00 72.67  ? 536 TYR A CD2 1 
ATOM   3947 C  CE1 . TYR A 1 536 ? 79.917  110.088 109.343 1.00 72.67  ? 536 TYR A CE1 1 
ATOM   3948 C  CE2 . TYR A 1 536 ? 81.374  109.595 107.517 1.00 72.67  ? 536 TYR A CE2 1 
ATOM   3949 C  CZ  . TYR A 1 536 ? 80.702  110.509 108.294 1.00 72.67  ? 536 TYR A CZ  1 
ATOM   3950 O  OH  . TYR A 1 536 ? 80.816  111.849 108.021 1.00 72.67  ? 536 TYR A OH  1 
ATOM   3951 N  N   . VAL A 1 537 ? 78.039  107.044 106.961 1.00 73.93  ? 537 VAL A N   1 
ATOM   3952 C  CA  . VAL A 1 537 ? 77.687  107.355 105.581 1.00 73.93  ? 537 VAL A CA  1 
ATOM   3953 C  C   . VAL A 1 537 ? 78.299  108.698 105.217 1.00 73.93  ? 537 VAL A C   1 
ATOM   3954 O  O   . VAL A 1 537 ? 78.107  109.692 105.924 1.00 73.93  ? 537 VAL A O   1 
ATOM   3955 C  CB  . VAL A 1 537 ? 76.159  107.372 105.370 1.00 73.93  ? 537 VAL A CB  1 
ATOM   3956 C  CG1 . VAL A 1 537 ? 75.831  107.551 103.900 1.00 73.93  ? 537 VAL A CG1 1 
ATOM   3957 C  CG2 . VAL A 1 537 ? 75.534  106.095 105.905 1.00 73.93  ? 537 VAL A CG2 1 
ATOM   3958 N  N   . TYR A 1 538 ? 79.016  108.727 104.135 1.00 70.66  ? 538 TYR A N   1 
ATOM   3959 C  CA  . TYR A 1 538 ? 79.665  109.969 103.762 1.00 70.66  ? 538 TYR A CA  1 
ATOM   3960 C  C   . TYR A 1 538 ? 78.710  110.866 102.985 1.00 70.66  ? 538 TYR A C   1 
ATOM   3961 O  O   . TYR A 1 538 ? 77.913  110.383 102.175 1.00 70.66  ? 538 TYR A O   1 
ATOM   3962 C  CB  . TYR A 1 538 ? 80.904  109.694 102.906 1.00 70.66  ? 538 TYR A CB  1 
ATOM   3963 C  CG  . TYR A 1 538 ? 82.177  109.525 103.704 1.00 70.66  ? 538 TYR A CG  1 
ATOM   3964 C  CD1 . TYR A 1 538 ? 82.444  108.341 104.377 1.00 70.66  ? 538 TYR A CD1 1 
ATOM   3965 C  CD2 . TYR A 1 538 ? 83.111  110.547 103.783 1.00 70.66  ? 538 TYR A CD2 1 
ATOM   3966 C  CE1 . TYR A 1 538 ? 83.600  108.181 105.105 1.00 70.66  ? 538 TYR A CE1 1 
ATOM   3967 C  CE2 . TYR A 1 538 ? 84.271  110.395 104.509 1.00 70.66  ? 538 TYR A CE2 1 
ATOM   3968 C  CZ  . TYR A 1 538 ? 84.510  109.209 105.167 1.00 70.66  ? 538 TYR A CZ  1 
ATOM   3969 O  OH  . TYR A 1 538 ? 85.664  109.050 105.893 1.00 70.66  ? 538 TYR A OH  1 
ATOM   3970 N  N   . PRO A 1 539 ? 78.764  112.175 103.215 1.00 73.34  ? 539 PRO A N   1 
ATOM   3971 C  CA  . PRO A 1 539 ? 78.007  113.106 102.372 1.00 73.34  ? 539 PRO A CA  1 
ATOM   3972 C  C   . PRO A 1 539 ? 78.519  113.084 100.940 1.00 73.34  ? 539 PRO A C   1 
ATOM   3973 O  O   . PRO A 1 539 ? 79.651  112.695 100.653 1.00 73.34  ? 539 PRO A O   1 
ATOM   3974 C  CB  . PRO A 1 539 ? 78.242  114.464 103.039 1.00 73.34  ? 539 PRO A CB  1 
ATOM   3975 C  CG  . PRO A 1 539 ? 78.604  114.133 104.447 1.00 73.34  ? 539 PRO A CG  1 
ATOM   3976 C  CD  . PRO A 1 539 ? 79.370  112.851 104.372 1.00 73.34  ? 539 PRO A CD  1 
ATOM   3977 N  N   . ASN A 1 540 ? 77.648  113.511 100.023 1.00 75.95  ? 540 ASN A N   1 
ATOM   3978 C  CA  . ASN A 1 540 ? 77.950  113.401 98.599  1.00 75.95  ? 540 ASN A CA  1 
ATOM   3979 C  C   . ASN A 1 540 ? 79.140  114.268 98.201  1.00 75.95  ? 540 ASN A C   1 
ATOM   3980 O  O   . ASN A 1 540 ? 79.951  113.867 97.357  1.00 75.95  ? 540 ASN A O   1 
ATOM   3981 C  CB  . ASN A 1 540 ? 76.714  113.767 97.780  1.00 75.95  ? 540 ASN A CB  1 
ATOM   3982 C  CG  . ASN A 1 540 ? 75.457  113.098 98.298  1.00 75.95  ? 540 ASN A CG  1 
ATOM   3983 O  OD1 . ASN A 1 540 ? 75.493  111.957 98.757  1.00 75.95  ? 540 ASN A OD1 1 
ATOM   3984 N  ND2 . ASN A 1 540 ? 74.338  113.808 98.231  1.00 75.95  ? 540 ASN A ND2 1 
ATOM   3985 N  N   . TRP A 1 541 ? 79.260  115.463 98.785  1.00 72.04  ? 541 TRP A N   1 
ATOM   3986 C  CA  . TRP A 1 541 ? 80.381  116.328 98.433  1.00 72.04  ? 541 TRP A CA  1 
ATOM   3987 C  C   . TRP A 1 541 ? 81.712  115.738 98.888  1.00 72.04  ? 541 TRP A C   1 
ATOM   3988 O  O   . TRP A 1 541 ? 82.736  115.958 98.234  1.00 72.04  ? 541 TRP A O   1 
ATOM   3989 C  CB  . TRP A 1 541 ? 80.175  117.735 99.004  1.00 72.04  ? 541 TRP A CB  1 
ATOM   3990 C  CG  . TRP A 1 541 ? 80.152  117.815 100.499 1.00 72.04  ? 541 TRP A CG  1 
ATOM   3991 C  CD1 . TRP A 1 541 ? 79.060  117.715 101.308 1.00 72.04  ? 541 TRP A CD1 1 
ATOM   3992 C  CD2 . TRP A 1 541 ? 81.274  118.022 101.366 1.00 72.04  ? 541 TRP A CD2 1 
ATOM   3993 N  NE1 . TRP A 1 541 ? 79.430  117.842 102.623 1.00 72.04  ? 541 TRP A NE1 1 
ATOM   3994 C  CE2 . TRP A 1 541 ? 80.785  118.030 102.685 1.00 72.04  ? 541 TRP A CE2 1 
ATOM   3995 C  CE3 . TRP A 1 541 ? 82.644  118.196 101.154 1.00 72.04  ? 541 TRP A CE3 1 
ATOM   3996 C  CZ2 . TRP A 1 541 ? 81.616  118.206 103.786 1.00 72.04  ? 541 TRP A CZ2 1 
ATOM   3997 C  CZ3 . TRP A 1 541 ? 83.466  118.369 102.247 1.00 72.04  ? 541 TRP A CZ3 1 
ATOM   3998 C  CH2 . TRP A 1 541 ? 82.951  118.372 103.546 1.00 72.04  ? 541 TRP A CH2 1 
ATOM   3999 N  N   . ALA A 1 542 ? 81.721  114.975 99.983  1.00 70.25  ? 542 ALA A N   1 
ATOM   4000 C  CA  . ALA A 1 542 ? 82.948  114.299 100.395 1.00 70.25  ? 542 ALA A CA  1 
ATOM   4001 C  C   . ALA A 1 542 ? 83.376  113.250 99.373  1.00 70.25  ? 542 ALA A C   1 
ATOM   4002 O  O   . ALA A 1 542 ? 84.566  113.134 99.050  1.00 70.25  ? 542 ALA A O   1 
ATOM   4003 C  CB  . ALA A 1 542 ? 82.761  113.665 101.771 1.00 70.25  ? 542 ALA A CB  1 
ATOM   4004 N  N   . ILE A 1 543 ? 82.420  112.475 98.854  1.00 71.99  ? 543 ILE A N   1 
ATOM   4005 C  CA  . ILE A 1 543 ? 82.735  111.494 97.820  1.00 71.99  ? 543 ILE A CA  1 
ATOM   4006 C  C   . ILE A 1 543 ? 83.215  112.194 96.556  1.00 71.99  ? 543 ILE A C   1 
ATOM   4007 O  O   . ILE A 1 543 ? 84.126  111.716 95.869  1.00 71.99  ? 543 ILE A O   1 
ATOM   4008 C  CB  . ILE A 1 543 ? 81.515  110.595 97.545  1.00 71.99  ? 543 ILE A CB  1 
ATOM   4009 C  CG1 . ILE A 1 543 ? 81.123  109.829 98.807  1.00 71.99  ? 543 ILE A CG1 1 
ATOM   4010 C  CG2 . ILE A 1 543 ? 81.808  109.625 96.420  1.00 71.99  ? 543 ILE A CG2 1 
ATOM   4011 C  CD1 . ILE A 1 543 ? 82.190  108.886 99.303  1.00 71.99  ? 543 ILE A CD1 1 
ATOM   4012 N  N   . GLY A 1 544 ? 82.605  113.334 96.225  1.00 71.26  ? 544 GLY A N   1 
ATOM   4013 C  CA  . GLY A 1 544 ? 83.094  114.116 95.101  1.00 71.26  ? 544 GLY A CA  1 
ATOM   4014 C  C   . GLY A 1 544 ? 84.522  114.585 95.299  1.00 71.26  ? 544 GLY A C   1 
ATOM   4015 O  O   . GLY A 1 544 ? 85.327  114.568 94.366  1.00 71.26  ? 544 GLY A O   1 
ATOM   4016 N  N   . LEU A 1 545 ? 84.857  115.003 96.522  1.00 69.92  ? 545 LEU A N   1 
ATOM   4017 C  CA  . LEU A 1 545 ? 86.225  115.411 96.827  1.00 69.92  ? 545 LEU A CA  1 
ATOM   4018 C  C   . LEU A 1 545 ? 87.200  114.248 96.677  1.00 69.92  ? 545 LEU A C   1 
ATOM   4019 O  O   . LEU A 1 545 ? 88.299  114.413 96.135  1.00 69.92  ? 545 LEU A O   1 
ATOM   4020 C  CB  . LEU A 1 545 ? 86.290  115.992 98.240  1.00 69.92  ? 545 LEU A CB  1 
ATOM   4021 C  CG  . LEU A 1 545 ? 87.669  116.268 98.841  1.00 69.92  ? 545 LEU A CG  1 
ATOM   4022 C  CD1 . LEU A 1 545 ? 88.252  117.556 98.290  1.00 69.92  ? 545 LEU A CD1 1 
ATOM   4023 C  CD2 . LEU A 1 545 ? 87.584  116.324 100.355 1.00 69.92  ? 545 LEU A CD2 1 
ATOM   4024 N  N   . GLY A 1 546 ? 86.815  113.062 97.152  1.00 69.04  ? 546 GLY A N   1 
ATOM   4025 C  CA  . GLY A 1 546 ? 87.675  111.897 96.988  1.00 69.04  ? 546 GLY A CA  1 
ATOM   4026 C  C   . GLY A 1 546 ? 87.885  111.520 95.532  1.00 69.04  ? 546 GLY A C   1 
ATOM   4027 O  O   . GLY A 1 546 ? 89.004  111.198 95.110  1.00 69.04  ? 546 GLY A O   1 
ATOM   4028 N  N   . TRP A 1 547 ? 86.811  111.550 94.743  1.00 71.66  ? 547 TRP A N   1 
ATOM   4029 C  CA  . TRP A 1 547 ? 86.944  111.262 93.322  1.00 71.66  ? 547 TRP A CA  1 
ATOM   4030 C  C   . TRP A 1 547 ? 87.790  112.314 92.621  1.00 71.66  ? 547 TRP A C   1 
ATOM   4031 O  O   . TRP A 1 547 ? 88.523  111.989 91.683  1.00 71.66  ? 547 TRP A O   1 
ATOM   4032 C  CB  . TRP A 1 547 ? 85.566  111.146 92.675  1.00 71.66  ? 547 TRP A CB  1 
ATOM   4033 C  CG  . TRP A 1 547 ? 85.026  109.753 92.731  1.00 71.66  ? 547 TRP A CG  1 
ATOM   4034 C  CD1 . TRP A 1 547 ? 84.027  109.294 93.535  1.00 71.66  ? 547 TRP A CD1 1 
ATOM   4035 C  CD2 . TRP A 1 547 ? 85.472  108.629 91.962  1.00 71.66  ? 547 TRP A CD2 1 
ATOM   4036 N  NE1 . TRP A 1 547 ? 83.817  107.956 93.311  1.00 71.66  ? 547 TRP A NE1 1 
ATOM   4037 C  CE2 . TRP A 1 547 ? 84.692  107.524 92.349  1.00 71.66  ? 547 TRP A CE2 1 
ATOM   4038 C  CE3 . TRP A 1 547 ? 86.453  108.452 90.982  1.00 71.66  ? 547 TRP A CE3 1 
ATOM   4039 C  CZ2 . TRP A 1 547 ? 84.861  106.260 91.790  1.00 71.66  ? 547 TRP A CZ2 1 
ATOM   4040 C  CZ3 . TRP A 1 547 ? 86.619  107.198 90.429  1.00 71.66  ? 547 TRP A CZ3 1 
ATOM   4041 C  CH2 . TRP A 1 547 ? 85.828  106.118 90.834  1.00 71.66  ? 547 TRP A CH2 1 
ATOM   4042 N  N   . SER A 1 548 ? 87.712  113.570 93.064  1.00 73.06  ? 548 SER A N   1 
ATOM   4043 C  CA  . SER A 1 548 ? 88.610  114.595 92.542  1.00 73.06  ? 548 SER A CA  1 
ATOM   4044 C  C   . SER A 1 548 ? 90.058  114.291 92.900  1.00 73.06  ? 548 SER A C   1 
ATOM   4045 O  O   . SER A 1 548 ? 90.963  114.514 92.089  1.00 73.06  ? 548 SER A O   1 
ATOM   4046 C  CB  . SER A 1 548 ? 88.202  115.968 93.071  1.00 73.06  ? 548 SER A CB  1 
ATOM   4047 O  OG  . SER A 1 548 ? 86.802  116.151 92.969  1.00 73.06  ? 548 SER A OG  1 
ATOM   4048 N  N   . LEU A 1 549 ? 90.296  113.788 94.114  1.00 70.19  ? 549 LEU A N   1 
ATOM   4049 C  CA  . LEU A 1 549 ? 91.648  113.397 94.506  1.00 70.19  ? 549 LEU A CA  1 
ATOM   4050 C  C   . LEU A 1 549 ? 92.200  112.329 93.570  1.00 70.19  ? 549 LEU A C   1 
ATOM   4051 O  O   . LEU A 1 549 ? 93.343  112.420 93.107  1.00 70.19  ? 549 LEU A O   1 
ATOM   4052 C  CB  . LEU A 1 549 ? 91.657  112.889 95.948  1.00 70.19  ? 549 LEU A CB  1 
ATOM   4053 C  CG  . LEU A 1 549 ? 91.864  113.892 97.082  1.00 70.19  ? 549 LEU A CG  1 
ATOM   4054 C  CD1 . LEU A 1 549 ? 91.747  113.192 98.427  1.00 70.19  ? 549 LEU A CD1 1 
ATOM   4055 C  CD2 . LEU A 1 549 ? 93.202  114.592 96.951  1.00 70.19  ? 549 LEU A CD2 1 
ATOM   4056 N  N   . ALA A 1 550 ? 91.397  111.300 93.286  1.00 71.33  ? 550 ALA A N   1 
ATOM   4057 C  CA  . ALA A 1 550 ? 91.850  110.242 92.381  1.00 71.33  ? 550 ALA A CA  1 
ATOM   4058 C  C   . ALA A 1 550 ? 92.039  110.763 90.957  1.00 71.33  ? 550 ALA A C   1 
ATOM   4059 O  O   . ALA A 1 550 ? 93.027  110.431 90.285  1.00 71.33  ? 550 ALA A O   1 
ATOM   4060 C  CB  . ALA A 1 550 ? 90.865  109.075 92.398  1.00 71.33  ? 550 ALA A CB  1 
ATOM   4061 N  N   . LEU A 1 551 ? 91.103  111.582 90.477  1.00 73.24  ? 551 LEU A N   1 
ATOM   4062 C  CA  . LEU A 1 551 ? 91.178  112.082 89.112  1.00 73.24  ? 551 LEU A CA  1 
ATOM   4063 C  C   . LEU A 1 551 ? 92.334  113.051 88.914  1.00 73.24  ? 551 LEU A C   1 
ATOM   4064 O  O   . LEU A 1 551 ? 92.837  113.168 87.794  1.00 73.24  ? 551 LEU A O   1 
ATOM   4065 C  CB  . LEU A 1 551 ? 89.858  112.749 88.730  1.00 73.24  ? 551 LEU A CB  1 
ATOM   4066 C  CG  . LEU A 1 551 ? 88.889  111.902 87.902  1.00 73.24  ? 551 LEU A CG  1 
ATOM   4067 C  CD1 . LEU A 1 551 ? 88.442  110.675 88.681  1.00 73.24  ? 551 LEU A CD1 1 
ATOM   4068 C  CD2 . LEU A 1 551 ? 87.691  112.729 87.470  1.00 73.24  ? 551 LEU A CD2 1 
ATOM   4069 N  N   . SER A 1 552 ? 92.776  113.734 89.971  1.00 75.56  ? 552 SER A N   1 
ATOM   4070 C  CA  . SER A 1 552 ? 93.941  114.603 89.849  1.00 75.56  ? 552 SER A CA  1 
ATOM   4071 C  C   . SER A 1 552 ? 95.164  113.813 89.405  1.00 75.56  ? 552 SER A C   1 
ATOM   4072 O  O   . SER A 1 552 ? 95.957  114.288 88.584  1.00 75.56  ? 552 SER A O   1 
ATOM   4073 C  CB  . SER A 1 552 ? 94.210  115.307 91.178  1.00 75.56  ? 552 SER A CB  1 
ATOM   4074 O  OG  . SER A 1 552 ? 94.298  114.371 92.237  1.00 75.56  ? 552 SER A OG  1 
ATOM   4075 N  N   . SER A 1 553 ? 95.333  112.604 89.941  1.00 75.55  ? 553 SER A N   1 
ATOM   4076 C  CA  . SER A 1 553 ? 96.412  111.732 89.496  1.00 75.55  ? 553 SER A CA  1 
ATOM   4077 C  C   . SER A 1 553 ? 96.106  111.097 88.145  1.00 75.55  ? 553 SER A C   1 
ATOM   4078 O  O   . SER A 1 553 ? 97.003  110.969 87.306  1.00 75.55  ? 553 SER A O   1 
ATOM   4079 C  CB  . SER A 1 553 ? 96.677  110.652 90.543  1.00 75.55  ? 553 SER A CB  1 
ATOM   4080 O  OG  . SER A 1 553 ? 97.337  109.542 89.967  1.00 75.55  ? 553 SER A OG  1 
ATOM   4081 N  N   . MET A 1 554 ? 94.852  110.691 87.915  1.00 77.45  ? 554 MET A N   1 
ATOM   4082 C  CA  . MET A 1 554 ? 94.528  110.015 86.657  1.00 77.45  ? 554 MET A CA  1 
ATOM   4083 C  C   . MET A 1 554 ? 94.746  110.913 85.445  1.00 77.45  ? 554 MET A C   1 
ATOM   4084 O  O   . MET A 1 554 ? 95.419  110.516 84.487  1.00 77.45  ? 554 MET A O   1 
ATOM   4085 C  CB  . MET A 1 554 ? 93.087  109.524 86.654  1.00 77.45  ? 554 MET A CB  1 
ATOM   4086 C  CG  . MET A 1 554 ? 92.768  108.425 87.614  1.00 77.45  ? 554 MET A CG  1 
ATOM   4087 S  SD  . MET A 1 554 ? 91.027  108.047 87.410  1.00 77.45  ? 554 MET A SD  1 
ATOM   4088 C  CE  . MET A 1 554 ? 90.826  106.821 88.671  1.00 77.45  ? 554 MET A CE  1 
ATOM   4089 N  N   . LEU A 1 555 ? 94.180  112.123 85.460  1.00 80.82  ? 555 LEU A N   1 
ATOM   4090 C  CA  . LEU A 1 555 ? 94.137  112.954 84.260  1.00 80.82  ? 555 LEU A CA  1 
ATOM   4091 C  C   . LEU A 1 555 ? 95.509  113.392 83.766  1.00 80.82  ? 555 LEU A C   1 
ATOM   4092 O  O   . LEU A 1 555 ? 95.590  113.984 82.687  1.00 80.82  ? 555 LEU A O   1 
ATOM   4093 C  CB  . LEU A 1 555 ? 93.258  114.189 84.482  1.00 80.82  ? 555 LEU A CB  1 
ATOM   4094 C  CG  . LEU A 1 555 ? 91.738  114.072 84.305  1.00 80.82  ? 555 LEU A CG  1 
ATOM   4095 C  CD1 . LEU A 1 555 ? 91.418  113.688 82.869  1.00 80.82  ? 555 LEU A CD1 1 
ATOM   4096 C  CD2 . LEU A 1 555 ? 91.101  113.082 85.258  1.00 80.82  ? 555 LEU A CD2 1 
ATOM   4097 N  N   . CYS A 1 556 ? 96.583  113.119 84.505  1.00 82.24  ? 556 CYS A N   1 
ATOM   4098 C  CA  . CYS A 1 556 ? 97.910  113.424 83.984  1.00 82.24  ? 556 CYS A CA  1 
ATOM   4099 C  C   . CYS A 1 556 ? 98.210  112.629 82.719  1.00 82.24  ? 556 CYS A C   1 
ATOM   4100 O  O   . CYS A 1 556 ? 98.860  113.145 81.804  1.00 82.24  ? 556 CYS A O   1 
ATOM   4101 C  CB  . CYS A 1 556 ? 98.970  113.155 85.051  1.00 82.24  ? 556 CYS A CB  1 
ATOM   4102 S  SG  . CYS A 1 556 ? 99.189  114.504 86.228  1.00 82.24  ? 556 CYS A SG  1 
ATOM   4103 N  N   . VAL A 1 557 ? 97.753  111.381 82.651  1.00 82.43  ? 557 VAL A N   1 
ATOM   4104 C  CA  . VAL A 1 557 ? 98.017  110.499 81.513  1.00 82.43  ? 557 VAL A CA  1 
ATOM   4105 C  C   . VAL A 1 557 ? 97.374  111.012 80.224  1.00 82.43  ? 557 VAL A C   1 
ATOM   4106 O  O   . VAL A 1 557 ? 98.064  111.071 79.197  1.00 82.43  ? 557 VAL A O   1 
ATOM   4107 C  CB  . VAL A 1 557 ? 97.571  109.058 81.817  1.00 82.43  ? 557 VAL A CB  1 
ATOM   4108 C  CG1 . VAL A 1 557 ? 98.083  108.111 80.749  1.00 82.43  ? 557 VAL A CG1 1 
ATOM   4109 C  CG2 . VAL A 1 557 ? 98.053  108.628 83.191  1.00 82.43  ? 557 VAL A CG2 1 
ATOM   4110 N  N   . PRO A 1 558 ? 96.071  111.384 80.194  1.00 82.66  ? 558 PRO A N   1 
ATOM   4111 C  CA  . PRO A 1 558 ? 95.492  111.853 78.925  1.00 82.66  ? 558 PRO A CA  1 
ATOM   4112 C  C   . PRO A 1 558 ? 95.809  113.305 78.592  1.00 82.66  ? 558 PRO A C   1 
ATOM   4113 O  O   . PRO A 1 558 ? 95.890  113.666 77.411  1.00 82.66  ? 558 PRO A O   1 
ATOM   4114 C  CB  . PRO A 1 558 ? 93.982  111.654 79.128  1.00 82.66  ? 558 PRO A CB  1 
ATOM   4115 C  CG  . PRO A 1 558 ? 93.838  110.847 80.373  1.00 82.66  ? 558 PRO A CG  1 
ATOM   4116 C  CD  . PRO A 1 558 ? 95.019  111.181 81.203  1.00 82.66  ? 558 PRO A CD  1 
ATOM   4117 N  N   . LEU A 1 559 ? 95.968  114.154 79.610  1.00 88.88  ? 559 LEU A N   1 
ATOM   4118 C  CA  . LEU A 1 559 ? 96.292  115.552 79.341  1.00 88.88  ? 559 LEU A CA  1 
ATOM   4119 C  C   . LEU A 1 559 ? 97.664  115.690 78.696  1.00 88.88  ? 559 LEU A C   1 
ATOM   4120 O  O   . LEU A 1 559 ? 97.844  116.500 77.782  1.00 88.88  ? 559 LEU A O   1 
ATOM   4121 C  CB  . LEU A 1 559 ? 96.212  116.388 80.618  1.00 88.88  ? 559 LEU A CB  1 
ATOM   4122 C  CG  . LEU A 1 559 ? 94.834  116.558 81.259  1.00 88.88  ? 559 LEU A CG  1 
ATOM   4123 C  CD1 . LEU A 1 559 ? 94.954  117.290 82.583  1.00 88.88  ? 559 LEU A CD1 1 
ATOM   4124 C  CD2 . LEU A 1 559 ? 93.896  117.295 80.320  1.00 88.88  ? 559 LEU A CD2 1 
ATOM   4125 N  N   . VAL A 1 560 ? 98.646  114.914 79.154  1.00 91.08  ? 560 VAL A N   1 
ATOM   4126 C  CA  . VAL A 1 560 ? 99.961  114.975 78.527  1.00 91.08  ? 560 VAL A CA  1 
ATOM   4127 C  C   . VAL A 1 560 ? 99.886  114.476 77.088  1.00 91.08  ? 560 VAL A C   1 
ATOM   4128 O  O   . VAL A 1 560 ? 100.556 115.011 76.196  1.00 91.08  ? 560 VAL A O   1 
ATOM   4129 C  CB  . VAL A 1 560 ? 100.997 114.201 79.366  1.00 91.08  ? 560 VAL A CB  1 
ATOM   4130 C  CG1 . VAL A 1 560 ? 100.819 112.702 79.219  1.00 91.08  ? 560 VAL A CG1 1 
ATOM   4131 C  CG2 . VAL A 1 560 ? 102.407 114.614 78.980  1.00 91.08  ? 560 VAL A CG2 1 
ATOM   4132 N  N   . ILE A 1 561 ? 99.039  113.475 76.828  1.00 91.89  ? 561 ILE A N   1 
ATOM   4133 C  CA  . ILE A 1 561 ? 98.886  112.956 75.473  1.00 91.89  ? 561 ILE A CA  1 
ATOM   4134 C  C   . ILE A 1 561 ? 98.302  114.023 74.557  1.00 91.89  ? 561 ILE A C   1 
ATOM   4135 O  O   . ILE A 1 561 ? 98.806  114.260 73.452  1.00 91.89  ? 561 ILE A O   1 
ATOM   4136 C  CB  . ILE A 1 561 ? 98.016  111.686 75.478  1.00 91.89  ? 561 ILE A CB  1 
ATOM   4137 C  CG1 . ILE A 1 561 ? 98.755  110.529 76.146  1.00 91.89  ? 561 ILE A CG1 1 
ATOM   4138 C  CG2 . ILE A 1 561 ? 97.621  111.305 74.062  1.00 91.89  ? 561 ILE A CG2 1 
ATOM   4139 C  CD1 . ILE A 1 561 ? 97.918  109.280 76.283  1.00 91.89  ? 561 ILE A CD1 1 
ATOM   4140 N  N   . VAL A 1 562 ? 97.230  114.686 75.002  1.00 95.87  ? 562 VAL A N   1 
ATOM   4141 C  CA  . VAL A 1 562 ? 96.602  115.695 74.152  1.00 95.87  ? 562 VAL A CA  1 
ATOM   4142 C  C   . VAL A 1 562 ? 97.507  116.912 73.995  1.00 95.87  ? 562 VAL A C   1 
ATOM   4143 O  O   . VAL A 1 562 ? 97.530  117.538 72.929  1.00 95.87  ? 562 VAL A O   1 
ATOM   4144 C  CB  . VAL A 1 562 ? 95.205  116.081 74.679  1.00 95.87  ? 562 VAL A CB  1 
ATOM   4145 C  CG1 . VAL A 1 562 ? 94.283  114.873 74.671  1.00 95.87  ? 562 VAL A CG1 1 
ATOM   4146 C  CG2 . VAL A 1 562 ? 95.281  116.684 76.063  1.00 95.87  ? 562 VAL A CG2 1 
ATOM   4147 N  N   . ILE A 1 563 ? 98.272  117.264 75.032  1.00 99.92  ? 563 ILE A N   1 
ATOM   4148 C  CA  . ILE A 1 563 ? 99.206  118.382 74.926  1.00 99.92  ? 563 ILE A CA  1 
ATOM   4149 C  C   . ILE A 1 563 ? 100.291 118.071 73.903  1.00 99.92  ? 563 ILE A C   1 
ATOM   4150 O  O   . ILE A 1 563 ? 100.621 118.902 73.048  1.00 99.92  ? 563 ILE A O   1 
ATOM   4151 C  CB  . ILE A 1 563 ? 99.808  118.709 76.304  1.00 99.92  ? 563 ILE A CB  1 
ATOM   4152 C  CG1 . ILE A 1 563 ? 98.801  119.479 77.159  1.00 99.92  ? 563 ILE A CG1 1 
ATOM   4153 C  CG2 . ILE A 1 563 ? 101.092 119.508 76.155  1.00 99.92  ? 563 ILE A CG2 1 
ATOM   4154 C  CD1 . ILE A 1 563 ? 99.065  119.380 78.644  1.00 99.92  ? 563 ILE A CD1 1 
ATOM   4155 N  N   . ARG A 1 564 ? 100.857 116.863 73.969  1.00 100.74 ? 564 ARG A N   1 
ATOM   4156 C  CA  . ARG A 1 564 ? 101.919 116.497 73.037  1.00 100.74 ? 564 ARG A CA  1 
ATOM   4157 C  C   . ARG A 1 564 ? 101.395 116.388 71.611  1.00 100.74 ? 564 ARG A C   1 
ATOM   4158 O  O   . ARG A 1 564 ? 102.077 116.794 70.664  1.00 100.74 ? 564 ARG A O   1 
ATOM   4159 C  CB  . ARG A 1 564 ? 102.573 115.191 73.481  1.00 100.74 ? 564 ARG A CB  1 
ATOM   4160 C  CG  . ARG A 1 564 ? 103.403 115.337 74.744  1.00 100.74 ? 564 ARG A CG  1 
ATOM   4161 C  CD  . ARG A 1 564 ? 104.065 114.033 75.140  1.00 100.74 ? 564 ARG A CD  1 
ATOM   4162 N  NE  . ARG A 1 564 ? 104.824 114.173 76.376  1.00 100.74 ? 564 ARG A NE  1 
ATOM   4163 C  CZ  . ARG A 1 564 ? 106.091 114.561 76.436  1.00 100.74 ? 564 ARG A CZ  1 
ATOM   4164 N  NH1 . ARG A 1 564 ? 106.777 114.850 75.342  1.00 100.74 ? 564 ARG A NH1 1 
ATOM   4165 N  NH2 . ARG A 1 564 ? 106.683 114.663 77.622  1.00 100.74 ? 564 ARG A NH2 1 
ATOM   4166 N  N   . LEU A 1 565 ? 100.189 115.847 71.434  1.00 106.61 ? 565 LEU A N   1 
ATOM   4167 C  CA  . LEU A 1 565 ? 99.621  115.720 70.099  1.00 106.61 ? 565 LEU A CA  1 
ATOM   4168 C  C   . LEU A 1 565 ? 99.070  117.032 69.557  1.00 106.61 ? 565 LEU A C   1 
ATOM   4169 O  O   . LEU A 1 565 ? 98.811  117.121 68.352  1.00 106.61 ? 565 LEU A O   1 
ATOM   4170 C  CB  . LEU A 1 565 ? 98.519  114.658 70.098  1.00 106.61 ? 565 LEU A CB  1 
ATOM   4171 C  CG  . LEU A 1 565 ? 99.004  113.209 70.168  1.00 106.61 ? 565 LEU A CG  1 
ATOM   4172 C  CD1 . LEU A 1 565 ? 97.832  112.248 70.261  1.00 106.61 ? 565 LEU A CD1 1 
ATOM   4173 C  CD2 . LEU A 1 565 ? 99.877  112.882 68.968  1.00 106.61 ? 565 LEU A CD2 1 
ATOM   4174 N  N   . CYS A 1 566 ? 98.876  118.043 70.408  1.00 113.99 ? 566 CYS A N   1 
ATOM   4175 C  CA  . CYS A 1 566 ? 98.385  119.329 69.925  1.00 113.99 ? 566 CYS A CA  1 
ATOM   4176 C  C   . CYS A 1 566 ? 99.396  120.002 69.004  1.00 113.99 ? 566 CYS A C   1 
ATOM   4177 O  O   . CYS A 1 566 ? 99.019  120.576 67.975  1.00 113.99 ? 566 CYS A O   1 
ATOM   4178 C  CB  . CYS A 1 566 ? 98.047  120.238 71.106  1.00 113.99 ? 566 CYS A CB  1 
ATOM   4179 S  SG  . CYS A 1 566 ? 97.210  121.773 70.649  1.00 113.99 ? 566 CYS A SG  1 
ATOM   4180 N  N   . GLN A 1 567 ? 100.677 119.942 69.352  1.00 112.98 ? 567 GLN A N   1 
ATOM   4181 C  CA  . GLN A 1 567 ? 101.718 120.558 68.536  1.00 112.98 ? 567 GLN A CA  1 
ATOM   4182 C  C   . GLN A 1 567 ? 102.711 119.515 68.034  1.00 112.98 ? 567 GLN A C   1 
ATOM   4183 O  O   . GLN A 1 567 ? 102.520 118.315 68.232  1.00 112.98 ? 567 GLN A O   1 
ATOM   4184 C  CB  . GLN A 1 567 ? 102.452 121.643 69.329  1.00 112.98 ? 567 GLN A CB  1 
ATOM   4185 C  CG  . GLN A 1 567 ? 103.389 121.106 70.400  1.00 112.98 ? 567 GLN A CG  1 
ATOM   4186 C  CD  . GLN A 1 567 ? 102.673 120.800 71.699  1.00 112.98 ? 567 GLN A CD  1 
ATOM   4187 O  OE1 . GLN A 1 567 ? 101.755 121.516 72.098  1.00 112.98 ? 567 GLN A OE1 1 
ATOM   4188 N  NE2 . GLN A 1 567 ? 103.087 119.729 72.367  1.00 112.98 ? 567 GLN A NE2 1 
HETATM 4189 C  C1  . NAG B 2 .   ? 88.528  106.606 138.902 1.00 118.34 ? 701 NAG A C1  1 
HETATM 4190 C  C2  . NAG B 2 .   ? 88.235  108.109 138.837 1.00 118.34 ? 701 NAG A C2  1 
HETATM 4191 C  C3  . NAG B 2 .   ? 87.876  108.637 140.226 1.00 118.34 ? 701 NAG A C3  1 
HETATM 4192 C  C4  . NAG B 2 .   ? 86.754  107.812 140.841 1.00 118.34 ? 701 NAG A C4  1 
HETATM 4193 C  C5  . NAG B 2 .   ? 87.128  106.334 140.830 1.00 118.34 ? 701 NAG A C5  1 
HETATM 4194 C  C6  . NAG B 2 .   ? 86.029  105.436 141.348 1.00 118.34 ? 701 NAG A C6  1 
HETATM 4195 C  C7  . NAG B 2 .   ? 89.258  109.812 137.385 1.00 118.34 ? 701 NAG A C7  1 
HETATM 4196 C  C8  . NAG B 2 .   ? 87.866  110.125 136.921 1.00 118.34 ? 701 NAG A C8  1 
HETATM 4197 N  N2  . NAG B 2 .   ? 89.371  108.838 138.295 1.00 118.34 ? 701 NAG A N2  1 
HETATM 4198 O  O3  . NAG B 2 .   ? 87.485  110.002 140.134 1.00 118.34 ? 701 NAG A O3  1 
HETATM 4199 O  O4  . NAG B 2 .   ? 86.519  108.227 142.182 1.00 118.34 ? 701 NAG A O4  1 
HETATM 4200 O  O5  . NAG B 2 .   ? 87.408  105.919 139.485 1.00 118.34 ? 701 NAG A O5  1 
HETATM 4201 O  O6  . NAG B 2 .   ? 86.561  104.334 142.071 1.00 118.34 ? 701 NAG A O6  1 
HETATM 4202 O  O7  . NAG B 2 .   ? 90.236  110.412 136.952 1.00 118.34 ? 701 NAG A O7  1 
HETATM 4203 C  C1  . NAG C 2 .   ? 81.743  88.500  137.091 1.00 139.64 ? 702 NAG A C1  1 
HETATM 4204 C  C2  . NAG C 2 .   ? 83.121  88.297  137.721 1.00 139.64 ? 702 NAG A C2  1 
HETATM 4205 C  C3  . NAG C 2 .   ? 82.977  87.797  139.157 1.00 139.64 ? 702 NAG A C3  1 
HETATM 4206 C  C4  . NAG C 2 .   ? 82.065  88.719  139.955 1.00 139.64 ? 702 NAG A C4  1 
HETATM 4207 C  C5  . NAG C 2 .   ? 80.736  88.908  139.231 1.00 139.64 ? 702 NAG A C5  1 
HETATM 4208 C  C6  . NAG C 2 .   ? 79.833  89.914  139.905 1.00 139.64 ? 702 NAG A C6  1 
HETATM 4209 C  C7  . NAG C 2 .   ? 85.259  87.402  136.910 1.00 139.64 ? 702 NAG A C7  1 
HETATM 4210 C  C8  . NAG C 2 .   ? 85.921  86.374  136.043 1.00 139.64 ? 702 NAG A C8  1 
HETATM 4211 N  N2  . NAG C 2 .   ? 83.922  87.373  136.935 1.00 139.64 ? 702 NAG A N2  1 
HETATM 4212 O  O3  . NAG C 2 .   ? 84.259  87.735  139.770 1.00 139.64 ? 702 NAG A O3  1 
HETATM 4213 O  O4  . NAG C 2 .   ? 81.822  88.166  141.244 1.00 139.64 ? 702 NAG A O4  1 
HETATM 4214 O  O5  . NAG C 2 .   ? 80.970  89.391  137.900 1.00 139.64 ? 702 NAG A O5  1 
HETATM 4215 O  O6  . NAG C 2 .   ? 79.914  91.186  139.276 1.00 139.64 ? 702 NAG A O6  1 
HETATM 4216 O  O7  . NAG C 2 .   ? 85.904  88.220  137.557 1.00 139.64 ? 702 NAG A O7  1 
HETATM 4217 C  C1  . NAG D 2 .   ? 72.752  100.473 123.391 1.00 137.40 ? 703 NAG A C1  1 
HETATM 4218 C  C2  . NAG D 2 .   ? 71.938  101.715 123.760 1.00 137.40 ? 703 NAG A C2  1 
HETATM 4219 C  C3  . NAG D 2 .   ? 70.503  101.584 123.252 1.00 137.40 ? 703 NAG A C3  1 
HETATM 4220 C  C4  . NAG D 2 .   ? 70.491  101.251 121.765 1.00 137.40 ? 703 NAG A C4  1 
HETATM 4221 C  C5  . NAG D 2 .   ? 71.366  100.032 121.487 1.00 137.40 ? 703 NAG A C5  1 
HETATM 4222 C  C6  . NAG D 2 .   ? 71.494  99.718  120.015 1.00 137.40 ? 703 NAG A C6  1 
HETATM 4223 C  C7  . NAG D 2 .   ? 71.483  101.123 126.120 1.00 137.40 ? 703 NAG A C7  1 
HETATM 4224 C  C8  . NAG D 2 .   ? 71.607  101.578 127.543 1.00 137.40 ? 703 NAG A C8  1 
HETATM 4225 N  N2  . NAG D 2 .   ? 71.961  101.966 125.194 1.00 137.40 ? 703 NAG A N2  1 
HETATM 4226 O  O3  . NAG D 2 .   ? 69.805  102.801 123.485 1.00 137.40 ? 703 NAG A O3  1 
HETATM 4227 O  O4  . NAG D 2 .   ? 69.161  100.977 121.340 1.00 137.40 ? 703 NAG A O4  1 
HETATM 4228 O  O5  . NAG D 2 .   ? 72.695  100.263 121.977 1.00 137.40 ? 703 NAG A O5  1 
HETATM 4229 O  O6  . NAG D 2 .   ? 72.628  98.901  119.755 1.00 137.40 ? 703 NAG A O6  1 
HETATM 4230 O  O7  . NAG D 2 .   ? 70.975  100.043 125.827 1.00 137.40 ? 703 NAG A O7  1 
HETATM 4231 NA NA  . NA  E 3 .   ? 111.884 100.803 105.606 1.00 83.20  ? 704 NA  A NA  1 
HETATM 4232 NA NA  . NA  F 3 .   ? 106.131 96.602  101.787 1.00 74.08  ? 705 NA  A NA  1 
HETATM 4233 CL CL  . CL  G 4 .   ? 102.397 93.363  101.468 1.00 63.96  ? 706 CL  A CL  1 
HETATM 4234 C  CAA . Y01 H 5 .   ? 92.267  118.851 91.046  1.00 98.95  ? 707 Y01 A CAA 1 
HETATM 4235 C  CBA . Y01 H 5 .   ? 93.538  118.955 91.871  1.00 98.95  ? 707 Y01 A CBA 1 
HETATM 4236 C  CAB . Y01 H 5 .   ? 93.221  118.876 93.354  1.00 98.95  ? 707 Y01 A CAB 1 
HETATM 4237 C  CAN . Y01 H 5 .   ? 94.323  120.210 91.530  1.00 98.95  ? 707 Y01 A CAN 1 
HETATM 4238 C  CAJ . Y01 H 5 .   ? 94.645  120.410 90.054  1.00 98.95  ? 707 Y01 A CAJ 1 
HETATM 4239 C  CAO . Y01 H 5 .   ? 95.565  119.336 89.483  1.00 98.95  ? 707 Y01 A CAO 1 
HETATM 4240 C  CBB . Y01 H 5 .   ? 95.846  119.439 87.973  1.00 98.95  ? 707 Y01 A CBB 1 
HETATM 4241 C  CAC . Y01 H 5 .   ? 95.160  120.669 87.381  1.00 98.95  ? 707 Y01 A CAC 1 
HETATM 4242 C  CBE . Y01 H 5 .   ? 97.362  119.398 87.702  1.00 98.95  ? 707 Y01 A CBE 1 
HETATM 4243 C  CAP . Y01 H 5 .   ? 98.079  118.376 88.608  1.00 98.95  ? 707 Y01 A CAP 1 
HETATM 4244 C  CAQ . Y01 H 5 .   ? 99.335  117.925 87.838  1.00 98.95  ? 707 Y01 A CAQ 1 
HETATM 4245 C  CBG . Y01 H 5 .   ? 99.359  118.807 86.582  1.00 98.95  ? 707 Y01 A CBG 1 
HETATM 4246 C  CBI . Y01 H 5 .   ? 97.868  119.058 86.282  1.00 98.95  ? 707 Y01 A CBI 1 
HETATM 4247 C  CAE . Y01 H 5 .   ? 97.182  117.795 85.736  1.00 98.95  ? 707 Y01 A CAE 1 
HETATM 4248 C  CAU . Y01 H 5 .   ? 97.824  120.182 85.239  1.00 98.95  ? 707 Y01 A CAU 1 
HETATM 4249 C  CAS . Y01 H 5 .   ? 98.612  119.822 83.981  1.00 98.95  ? 707 Y01 A CAS 1 
HETATM 4250 C  CBF . Y01 H 5 .   ? 100.068 119.421 84.256  1.00 98.95  ? 707 Y01 A CBF 1 
HETATM 4251 C  CBD . Y01 H 5 .   ? 100.178 118.364 85.364  1.00 98.95  ? 707 Y01 A CBD 1 
HETATM 4252 C  CAK . Y01 H 5 .   ? 101.641 118.170 85.741  1.00 98.95  ? 707 Y01 A CAK 1 
HETATM 4253 C  CAI . Y01 H 5 .   ? 102.516 118.030 84.537  1.00 98.95  ? 707 Y01 A CAI 1 
HETATM 4254 C  CAZ . Y01 H 5 .   ? 102.184 118.399 83.308  1.00 98.95  ? 707 Y01 A CAZ 1 
HETATM 4255 C  CAV . Y01 H 5 .   ? 103.144 118.198 82.159  1.00 98.95  ? 707 Y01 A CAV 1 
HETATM 4256 C  CBH . Y01 H 5 .   ? 100.834 119.020 82.963  1.00 98.95  ? 707 Y01 A CBH 1 
HETATM 4257 C  CAD . Y01 H 5 .   ? 100.037 118.003 82.123  1.00 98.95  ? 707 Y01 A CAD 1 
HETATM 4258 C  CAT . Y01 H 5 .   ? 101.082 120.283 82.126  1.00 98.95  ? 707 Y01 A CAT 1 
HETATM 4259 C  CAR . Y01 H 5 .   ? 101.936 119.984 80.896  1.00 98.95  ? 707 Y01 A CAR 1 
HETATM 4260 C  CBC . Y01 H 5 .   ? 103.288 119.446 81.306  1.00 98.95  ? 707 Y01 A CBC 1 
HETATM 4261 O  OAW . Y01 H 5 .   ? 103.994 119.059 80.086  1.00 98.95  ? 707 Y01 A OAW 1 
HETATM 4262 C  CAY . Y01 H 5 .   ? 105.283 119.405 79.976  1.00 98.95  ? 707 Y01 A CAY 1 
HETATM 4263 O  OAG . Y01 H 5 .   ? 105.916 119.913 80.861  1.00 98.95  ? 707 Y01 A OAG 1 
HETATM 4264 C  CAM . Y01 H 5 .   ? 105.817 119.077 78.614  1.00 98.95  ? 707 Y01 A CAM 1 
HETATM 4265 C  CAL . Y01 H 5 .   ? 104.777 119.218 77.519  1.00 98.95  ? 707 Y01 A CAL 1 
HETATM 4266 C  CAX . Y01 H 5 .   ? 105.351 119.126 76.136  1.00 98.95  ? 707 Y01 A CAX 1 
HETATM 4267 O  OAH . Y01 H 5 .   ? 104.668 119.050 75.136  1.00 98.95  ? 707 Y01 A OAH 1 
HETATM 4268 O  OAF . Y01 H 5 .   ? 106.659 119.140 76.116  1.00 98.95  ? 707 Y01 A OAF 1 
HETATM 4269 C  CAA . Y01 I 5 .   ? 99.364  118.801 94.558  1.00 112.78 ? 708 Y01 A CAA 1 
HETATM 4270 C  CBA . Y01 I 5 .   ? 100.156 118.693 93.268  1.00 112.78 ? 708 Y01 A CBA 1 
HETATM 4271 C  CAB . Y01 I 5 .   ? 99.237  118.364 92.108  1.00 112.78 ? 708 Y01 A CAB 1 
HETATM 4272 C  CAN . Y01 I 5 .   ? 101.285 117.686 93.394  1.00 112.78 ? 708 Y01 A CAN 1 
HETATM 4273 C  CAJ . Y01 I 5 .   ? 102.202 117.557 92.185  1.00 112.78 ? 708 Y01 A CAJ 1 
HETATM 4274 C  CAO . Y01 I 5 .   ? 102.875 118.871 91.803  1.00 112.78 ? 708 Y01 A CAO 1 
HETATM 4275 C  CBB . Y01 I 5 .   ? 103.950 118.774 90.706  1.00 112.78 ? 708 Y01 A CBB 1 
HETATM 4276 C  CAC . Y01 I 5 .   ? 104.271 117.317 90.391  1.00 112.78 ? 708 Y01 A CAC 1 
HETATM 4277 C  CBE . Y01 I 5 .   ? 103.542 119.582 89.459  1.00 112.78 ? 708 Y01 A CBE 1 
HETATM 4278 C  CAP . Y01 I 5 .   ? 102.553 120.715 89.797  1.00 112.78 ? 708 Y01 A CAP 1 
HETATM 4279 C  CAQ . Y01 I 5 .   ? 102.713 121.759 88.671  1.00 112.78 ? 708 Y01 A CAQ 1 
HETATM 4280 C  CBG . Y01 I 5 .   ? 103.747 121.149 87.709  1.00 112.78 ? 708 Y01 A CBG 1 
HETATM 4281 C  CBI . Y01 I 5 .   ? 104.635 120.286 88.627  1.00 112.78 ? 708 Y01 A CBI 1 
HETATM 4282 C  CAE . Y01 I 5 .   ? 105.538 121.156 89.518  1.00 112.78 ? 708 Y01 A CAE 1 
HETATM 4283 C  CAU . Y01 I 5 .   ? 105.485 119.403 87.707  1.00 112.78 ? 708 Y01 A CAU 1 
HETATM 4284 C  CAS . Y01 I 5 .   ? 106.310 120.239 86.729  1.00 112.78 ? 708 Y01 A CAS 1 
HETATM 4285 C  CBF . Y01 I 5 .   ? 105.468 121.210 85.890  1.00 112.78 ? 708 Y01 A CBF 1 
HETATM 4286 C  CBD . Y01 I 5 .   ? 104.526 122.061 86.755  1.00 112.78 ? 708 Y01 A CBD 1 
HETATM 4287 C  CAK . Y01 I 5 .   ? 103.567 122.838 85.859  1.00 112.78 ? 708 Y01 A CAK 1 
HETATM 4288 C  CAI . Y01 I 5 .   ? 104.258 123.465 84.690  1.00 112.78 ? 708 Y01 A CAI 1 
HETATM 4289 C  CAZ . Y01 I 5 .   ? 105.467 123.138 84.255  1.00 112.78 ? 708 Y01 A CAZ 1 
HETATM 4290 C  CAV . Y01 I 5 .   ? 106.072 123.848 83.065  1.00 112.78 ? 708 Y01 A CAV 1 
HETATM 4291 C  CBH . Y01 I 5 .   ? 106.329 122.066 84.915  1.00 112.78 ? 708 Y01 A CBH 1 
HETATM 4292 C  CAD . Y01 I 5 .   ? 107.488 122.766 85.649  1.00 112.78 ? 708 Y01 A CAD 1 
HETATM 4293 C  CAT . Y01 I 5 .   ? 106.901 121.142 83.827  1.00 112.78 ? 708 Y01 A CAT 1 
HETATM 4294 C  CAR . Y01 I 5 .   ? 107.603 121.912 82.709  1.00 112.78 ? 708 Y01 A CAR 1 
HETATM 4295 C  CBC . Y01 I 5 .   ? 106.633 122.867 82.053  1.00 112.78 ? 708 Y01 A CBC 1 
HETATM 4296 O  OAW . Y01 I 5 .   ? 107.343 123.628 81.028  1.00 112.78 ? 708 Y01 A OAW 1 
HETATM 4297 C  CAY . Y01 I 5 .   ? 106.839 123.606 79.786  1.00 112.78 ? 708 Y01 A CAY 1 
HETATM 4298 O  OAG . Y01 I 5 .   ? 105.702 123.310 79.531  1.00 112.78 ? 708 Y01 A OAG 1 
HETATM 4299 C  CAM . Y01 I 5 .   ? 107.874 123.996 78.773  1.00 112.78 ? 708 Y01 A CAM 1 
HETATM 4300 C  CAL . Y01 I 5 .   ? 108.692 122.817 78.276  1.00 112.78 ? 708 Y01 A CAL 1 
HETATM 4301 C  CAX . Y01 I 5 .   ? 109.521 122.171 79.348  1.00 112.78 ? 708 Y01 A CAX 1 
HETATM 4302 O  OAH . Y01 I 5 .   ? 109.717 120.974 79.407  1.00 112.78 ? 708 Y01 A OAH 1 
HETATM 4303 O  OAF . Y01 I 5 .   ? 110.009 123.025 80.209  1.00 112.78 ? 708 Y01 A OAF 1 
HETATM 4304 C  CAA . Y01 J 5 .   ? 100.894 118.046 97.882  1.00 112.93 ? 709 Y01 A CAA 1 
HETATM 4305 C  CBA . Y01 J 5 .   ? 101.429 119.422 98.234  1.00 112.93 ? 709 Y01 A CBA 1 
HETATM 4306 C  CAB . Y01 J 5 .   ? 100.507 120.115 99.216  1.00 112.93 ? 709 Y01 A CAB 1 
HETATM 4307 C  CAN . Y01 J 5 .   ? 102.845 119.352 98.773  1.00 112.93 ? 709 Y01 A CAN 1 
HETATM 4308 C  CAJ . Y01 J 5 .   ? 103.931 119.098 97.738  1.00 112.93 ? 709 Y01 A CAJ 1 
HETATM 4309 C  CAO . Y01 J 5 .   ? 103.880 120.082 96.576  1.00 112.93 ? 709 Y01 A CAO 1 
HETATM 4310 C  CBB . Y01 J 5 .   ? 105.168 120.166 95.741  1.00 112.93 ? 709 Y01 A CBB 1 
HETATM 4311 C  CAC . Y01 J 5 .   ? 105.600 118.776 95.284  1.00 112.93 ? 709 Y01 A CAC 1 
HETATM 4312 C  CBE . Y01 J 5 .   ? 105.004 121.162 94.576  1.00 112.93 ? 709 Y01 A CBE 1 
HETATM 4313 C  CAP . Y01 J 5 .   ? 103.948 122.242 94.877  1.00 112.93 ? 709 Y01 A CAP 1 
HETATM 4314 C  CAQ . Y01 J 5 .   ? 104.305 123.437 93.966  1.00 112.93 ? 709 Y01 A CAQ 1 
HETATM 4315 C  CBG . Y01 J 5 .   ? 105.529 122.972 93.160  1.00 112.93 ? 709 Y01 A CBG 1 
HETATM 4316 C  CBI . Y01 J 5 .   ? 106.229 121.972 94.101  1.00 112.93 ? 709 Y01 A CBI 1 
HETATM 4317 C  CAE . Y01 J 5 .   ? 106.910 122.690 95.278  1.00 112.93 ? 709 Y01 A CAE 1 
HETATM 4318 C  CAU . Y01 J 5 .   ? 107.266 121.229 93.254  1.00 112.93 ? 709 Y01 A CAU 1 
HETATM 4319 C  CAS . Y01 J 5 .   ? 108.260 122.193 92.607  1.00 112.93 ? 709 Y01 A CAS 1 
HETATM 4320 C  CBF . Y01 J 5 .   ? 107.593 123.295 91.773  1.00 112.93 ? 709 Y01 A CBF 1 
HETATM 4321 C  CBD . Y01 J 5 .   ? 106.468 124.011 92.537  1.00 112.93 ? 709 Y01 A CBD 1 
HETATM 4322 C  CAK . Y01 J 5 .   ? 105.702 124.929 91.587  1.00 112.93 ? 709 Y01 A CAK 1 
HETATM 4323 C  CAI . Y01 J 5 .   ? 106.599 125.685 90.657  1.00 112.93 ? 709 Y01 A CAI 1 
HETATM 4324 C  CAZ . Y01 J 5 .   ? 107.882 125.418 90.451  1.00 112.93 ? 709 Y01 A CAZ 1 
HETATM 4325 C  CAV . Y01 J 5 .   ? 108.694 126.252 89.485  1.00 112.93 ? 709 Y01 A CAV 1 
HETATM 4326 C  CBH . Y01 J 5 .   ? 108.620 124.290 91.160  1.00 112.93 ? 709 Y01 A CBH 1 
HETATM 4327 C  CAD . Y01 J 5 .   ? 109.527 124.910 92.241  1.00 112.93 ? 709 Y01 A CAD 1 
HETATM 4328 C  CAT . Y01 J 5 .   ? 109.486 123.538 90.138  1.00 112.93 ? 709 Y01 A CAT 1 
HETATM 4329 C  CAR . Y01 J 5 .   ? 109.143 123.923 88.700  1.00 112.93 ? 709 Y01 A CAR 1 
HETATM 4330 C  CBC . Y01 J 5 .   ? 109.426 125.390 88.472  1.00 112.93 ? 709 Y01 A CBC 1 
HETATM 4331 O  OAW . Y01 J 5 .   ? 110.860 125.615 88.641  1.00 112.93 ? 709 Y01 A OAW 1 
HETATM 4332 C  CAY . Y01 J 5 .   ? 111.495 126.300 87.681  1.00 112.93 ? 709 Y01 A CAY 1 
HETATM 4333 O  OAG . Y01 J 5 .   ? 111.631 125.902 86.555  1.00 112.93 ? 709 Y01 A OAG 1 
HETATM 4334 C  CAM . Y01 J 5 .   ? 112.001 127.614 88.199  1.00 112.93 ? 709 Y01 A CAM 1 
HETATM 4335 C  CAL . Y01 J 5 .   ? 112.091 128.687 87.128  1.00 112.93 ? 709 Y01 A CAL 1 
HETATM 4336 C  CAX . Y01 J 5 .   ? 113.182 128.442 86.127  1.00 112.93 ? 709 Y01 A CAX 1 
HETATM 4337 O  OAH . Y01 J 5 .   ? 112.983 127.959 85.031  1.00 112.93 ? 709 Y01 A OAH 1 
HETATM 4338 O  OAF . Y01 J 5 .   ? 114.366 128.800 86.552  1.00 112.93 ? 709 Y01 A OAF 1 
HETATM 4339 N  N01 . 3S5 K 6 .   ? 105.644 102.626 98.760  1.00 69.31  ? 710 3S5 A N01 1 
HETATM 4340 C  C02 . 3S5 K 6 .   ? 104.654 102.945 99.460  1.00 69.31  ? 710 3S5 A C02 1 
HETATM 4341 N  N03 . 3S5 K 6 .   ? 103.602 103.409 98.904  1.00 69.31  ? 710 3S5 A N03 1 
HETATM 4342 N  N04 . 3S5 K 6 .   ? 104.713 102.789 100.891 1.00 69.31  ? 710 3S5 A N04 1 
HETATM 4343 C  C05 . 3S5 K 6 .   ? 105.889 102.266 101.511 1.00 69.31  ? 710 3S5 A C05 1 
HETATM 4344 C  C06 . 3S5 K 6 .   ? 105.939 100.743 101.348 1.00 69.31  ? 710 3S5 A C06 1 
HETATM 4345 S  S07 . 3S5 K 6 .   ? 106.355 100.014 102.949 1.00 69.31  ? 710 3S5 A S07 1 
HETATM 4346 O  O08 . 3S5 K 6 .   ? 105.407 100.656 104.099 1.00 69.31  ? 710 3S5 A O08 1 
HETATM 4347 O  O09 . 3S5 K 6 .   ? 106.136 98.364  102.882 1.00 69.31  ? 710 3S5 A O09 1 
HETATM 4348 O  O10 . 3S5 K 6 .   ? 107.914 100.357 103.302 1.00 69.31  ? 710 3S5 A O10 1 
HETATM 4349 O  O   . HOH L 7 .   ? 102.289 103.588 96.606  1.00 68.22  ? 801 HOH A O   1 
# 
