data_9JCA
# 
_entry.id   9JCA 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9JCA         pdb_00009jca 10.2210/pdb9jca/pdb 
WWPDB D_1300050875 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-02 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9JCA 
_pdbx_database_status.recvd_initial_deposition_date   2024-08-29 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              wenshanyew@nus.edu.sg 
_pdbx_contact_author.name_first         'Wen Shan' 
_pdbx_contact_author.name_last          Yew 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-3021-0469 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Xue, B.'    1 0000-0002-5172-2519 
'Ling, L.H.' 2 0000-0003-1310-0046 
'Jia, X.'    3 0000-0003-0133-8321 
'Yew, W.S.'  4 0000-0002-3021-0469 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Acs Sustain Chem Eng' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2168-0485 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            13 
_citation.language                  ? 
_citation.page_first                2830 
_citation.page_last                 2844 
_citation.title                     
'Sustainable Biosynthesis of Diverse Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) for Industrial Production' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/acssuschemeng.4c08793 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Ling, L.H.'     1  ? 
primary 'Chua, E.T.'     2  ? 
primary 'Xue, B.'        3  ? 
primary 'Jia, X.'        4  ? 
primary 'Chow, J.Y.'     5  ? 
primary 'Yang, R.L.'     6  ? 
primary 'Lim, Y.P.'      7  ? 
primary 'Han, P.'        8  ? 
primary 'Xie, H.'        9  ? 
primary 'Tan, C.H.'      10 ? 
primary 'Nguyen, G.K.T.' 11 ? 
primary 'Yew, W.S.'      12 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man Lipase                                   48363.188 1 3.1.1.3 ? ? ? 
2 non-polymer syn 2-acetamido-2-deoxy-beta-D-glucopyranose 221.208   1 ?       ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;VMHHHHHHVPMERRAPFPDPNDDPFYKTPSNIGTYANGQVIQSRKAPTDIGNQNGADSFQLSYRTTNTQKEAQANVATVF
IPSKPASPPKIFSYQVYEDSTQLNCAPSYSYLTGFDEPNKVTTVLDTPIIISWALQQGYYVVSSDHEGPRSAFIAGYEEG
MAILDGIRAFKNFKNLPEDIGVGFYGYSGGAHATAWAVSLAEGYAPEIKIDGAAYGGTPASAKDTFTFLNKGFFAGFAVA
GVSGLALAHPDMEAFLEPRLNAKGKQVFEQIRSRGFCLPSVVLHNNFVDVFSLVNDTNLLIEEPIAGILKQETLVQAEAS
YTVPVPKFPRFMWHALPDEIVPFQPAANYVKEQCQKGANINWNVYPIAEHVTAEIFGLVPGLDFLSKAFKGQTPKVACGS
GVPAIPGINSPSTQNVLGSDLANQLNSLKGQQSAFGKPFGSVSPPL
;
_entity_poly.pdbx_seq_one_letter_code_can   
;VMHHHHHHVPMERRAPFPDPNDDPFYKTPSNIGTYANGQVIQSRKAPTDIGNQNGADSFQLSYRTTNTQKEAQANVATVF
IPSKPASPPKIFSYQVYEDSTQLNCAPSYSYLTGFDEPNKVTTVLDTPIIISWALQQGYYVVSSDHEGPRSAFIAGYEEG
MAILDGIRAFKNFKNLPEDIGVGFYGYSGGAHATAWAVSLAEGYAPEIKIDGAAYGGTPASAKDTFTFLNKGFFAGFAVA
GVSGLALAHPDMEAFLEPRLNAKGKQVFEQIRSRGFCLPSVVLHNNFVDVFSLVNDTNLLIEEPIAGILKQETLVQAEAS
YTVPVPKFPRFMWHALPDEIVPFQPAANYVKEQCQKGANINWNVYPIAEHVTAEIFGLVPGLDFLSKAFKGQTPKVACGS
GVPAIPGINSPSTQNVLGSDLANQLNSLKGQQSAFGKPFGSVSPPL
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        2-acetamido-2-deoxy-beta-D-glucopyranose 
_pdbx_entity_nonpoly.comp_id     NAG 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   VAL n 
1 2   MET n 
1 3   HIS n 
1 4   HIS n 
1 5   HIS n 
1 6   HIS n 
1 7   HIS n 
1 8   HIS n 
1 9   VAL n 
1 10  PRO n 
1 11  MET n 
1 12  GLU n 
1 13  ARG n 
1 14  ARG n 
1 15  ALA n 
1 16  PRO n 
1 17  PHE n 
1 18  PRO n 
1 19  ASP n 
1 20  PRO n 
1 21  ASN n 
1 22  ASP n 
1 23  ASP n 
1 24  PRO n 
1 25  PHE n 
1 26  TYR n 
1 27  LYS n 
1 28  THR n 
1 29  PRO n 
1 30  SER n 
1 31  ASN n 
1 32  ILE n 
1 33  GLY n 
1 34  THR n 
1 35  TYR n 
1 36  ALA n 
1 37  ASN n 
1 38  GLY n 
1 39  GLN n 
1 40  VAL n 
1 41  ILE n 
1 42  GLN n 
1 43  SER n 
1 44  ARG n 
1 45  LYS n 
1 46  ALA n 
1 47  PRO n 
1 48  THR n 
1 49  ASP n 
1 50  ILE n 
1 51  GLY n 
1 52  ASN n 
1 53  GLN n 
1 54  ASN n 
1 55  GLY n 
1 56  ALA n 
1 57  ASP n 
1 58  SER n 
1 59  PHE n 
1 60  GLN n 
1 61  LEU n 
1 62  SER n 
1 63  TYR n 
1 64  ARG n 
1 65  THR n 
1 66  THR n 
1 67  ASN n 
1 68  THR n 
1 69  GLN n 
1 70  LYS n 
1 71  GLU n 
1 72  ALA n 
1 73  GLN n 
1 74  ALA n 
1 75  ASN n 
1 76  VAL n 
1 77  ALA n 
1 78  THR n 
1 79  VAL n 
1 80  PHE n 
1 81  ILE n 
1 82  PRO n 
1 83  SER n 
1 84  LYS n 
1 85  PRO n 
1 86  ALA n 
1 87  SER n 
1 88  PRO n 
1 89  PRO n 
1 90  LYS n 
1 91  ILE n 
1 92  PHE n 
1 93  SER n 
1 94  TYR n 
1 95  GLN n 
1 96  VAL n 
1 97  TYR n 
1 98  GLU n 
1 99  ASP n 
1 100 SER n 
1 101 THR n 
1 102 GLN n 
1 103 LEU n 
1 104 ASN n 
1 105 CYS n 
1 106 ALA n 
1 107 PRO n 
1 108 SER n 
1 109 TYR n 
1 110 SER n 
1 111 TYR n 
1 112 LEU n 
1 113 THR n 
1 114 GLY n 
1 115 PHE n 
1 116 ASP n 
1 117 GLU n 
1 118 PRO n 
1 119 ASN n 
1 120 LYS n 
1 121 VAL n 
1 122 THR n 
1 123 THR n 
1 124 VAL n 
1 125 LEU n 
1 126 ASP n 
1 127 THR n 
1 128 PRO n 
1 129 ILE n 
1 130 ILE n 
1 131 ILE n 
1 132 SER n 
1 133 TRP n 
1 134 ALA n 
1 135 LEU n 
1 136 GLN n 
1 137 GLN n 
1 138 GLY n 
1 139 TYR n 
1 140 TYR n 
1 141 VAL n 
1 142 VAL n 
1 143 SER n 
1 144 SER n 
1 145 ASP n 
1 146 HIS n 
1 147 GLU n 
1 148 GLY n 
1 149 PRO n 
1 150 ARG n 
1 151 SER n 
1 152 ALA n 
1 153 PHE n 
1 154 ILE n 
1 155 ALA n 
1 156 GLY n 
1 157 TYR n 
1 158 GLU n 
1 159 GLU n 
1 160 GLY n 
1 161 MET n 
1 162 ALA n 
1 163 ILE n 
1 164 LEU n 
1 165 ASP n 
1 166 GLY n 
1 167 ILE n 
1 168 ARG n 
1 169 ALA n 
1 170 PHE n 
1 171 LYS n 
1 172 ASN n 
1 173 PHE n 
1 174 LYS n 
1 175 ASN n 
1 176 LEU n 
1 177 PRO n 
1 178 GLU n 
1 179 ASP n 
1 180 ILE n 
1 181 GLY n 
1 182 VAL n 
1 183 GLY n 
1 184 PHE n 
1 185 TYR n 
1 186 GLY n 
1 187 TYR n 
1 188 SER n 
1 189 GLY n 
1 190 GLY n 
1 191 ALA n 
1 192 HIS n 
1 193 ALA n 
1 194 THR n 
1 195 ALA n 
1 196 TRP n 
1 197 ALA n 
1 198 VAL n 
1 199 SER n 
1 200 LEU n 
1 201 ALA n 
1 202 GLU n 
1 203 GLY n 
1 204 TYR n 
1 205 ALA n 
1 206 PRO n 
1 207 GLU n 
1 208 ILE n 
1 209 LYS n 
1 210 ILE n 
1 211 ASP n 
1 212 GLY n 
1 213 ALA n 
1 214 ALA n 
1 215 TYR n 
1 216 GLY n 
1 217 GLY n 
1 218 THR n 
1 219 PRO n 
1 220 ALA n 
1 221 SER n 
1 222 ALA n 
1 223 LYS n 
1 224 ASP n 
1 225 THR n 
1 226 PHE n 
1 227 THR n 
1 228 PHE n 
1 229 LEU n 
1 230 ASN n 
1 231 LYS n 
1 232 GLY n 
1 233 PHE n 
1 234 PHE n 
1 235 ALA n 
1 236 GLY n 
1 237 PHE n 
1 238 ALA n 
1 239 VAL n 
1 240 ALA n 
1 241 GLY n 
1 242 VAL n 
1 243 SER n 
1 244 GLY n 
1 245 LEU n 
1 246 ALA n 
1 247 LEU n 
1 248 ALA n 
1 249 HIS n 
1 250 PRO n 
1 251 ASP n 
1 252 MET n 
1 253 GLU n 
1 254 ALA n 
1 255 PHE n 
1 256 LEU n 
1 257 GLU n 
1 258 PRO n 
1 259 ARG n 
1 260 LEU n 
1 261 ASN n 
1 262 ALA n 
1 263 LYS n 
1 264 GLY n 
1 265 LYS n 
1 266 GLN n 
1 267 VAL n 
1 268 PHE n 
1 269 GLU n 
1 270 GLN n 
1 271 ILE n 
1 272 ARG n 
1 273 SER n 
1 274 ARG n 
1 275 GLY n 
1 276 PHE n 
1 277 CYS n 
1 278 LEU n 
1 279 PRO n 
1 280 SER n 
1 281 VAL n 
1 282 VAL n 
1 283 LEU n 
1 284 HIS n 
1 285 ASN n 
1 286 ASN n 
1 287 PHE n 
1 288 VAL n 
1 289 ASP n 
1 290 VAL n 
1 291 PHE n 
1 292 SER n 
1 293 LEU n 
1 294 VAL n 
1 295 ASN n 
1 296 ASP n 
1 297 THR n 
1 298 ASN n 
1 299 LEU n 
1 300 LEU n 
1 301 ILE n 
1 302 GLU n 
1 303 GLU n 
1 304 PRO n 
1 305 ILE n 
1 306 ALA n 
1 307 GLY n 
1 308 ILE n 
1 309 LEU n 
1 310 LYS n 
1 311 GLN n 
1 312 GLU n 
1 313 THR n 
1 314 LEU n 
1 315 VAL n 
1 316 GLN n 
1 317 ALA n 
1 318 GLU n 
1 319 ALA n 
1 320 SER n 
1 321 TYR n 
1 322 THR n 
1 323 VAL n 
1 324 PRO n 
1 325 VAL n 
1 326 PRO n 
1 327 LYS n 
1 328 PHE n 
1 329 PRO n 
1 330 ARG n 
1 331 PHE n 
1 332 MET n 
1 333 TRP n 
1 334 HIS n 
1 335 ALA n 
1 336 LEU n 
1 337 PRO n 
1 338 ASP n 
1 339 GLU n 
1 340 ILE n 
1 341 VAL n 
1 342 PRO n 
1 343 PHE n 
1 344 GLN n 
1 345 PRO n 
1 346 ALA n 
1 347 ALA n 
1 348 ASN n 
1 349 TYR n 
1 350 VAL n 
1 351 LYS n 
1 352 GLU n 
1 353 GLN n 
1 354 CYS n 
1 355 GLN n 
1 356 LYS n 
1 357 GLY n 
1 358 ALA n 
1 359 ASN n 
1 360 ILE n 
1 361 ASN n 
1 362 TRP n 
1 363 ASN n 
1 364 VAL n 
1 365 TYR n 
1 366 PRO n 
1 367 ILE n 
1 368 ALA n 
1 369 GLU n 
1 370 HIS n 
1 371 VAL n 
1 372 THR n 
1 373 ALA n 
1 374 GLU n 
1 375 ILE n 
1 376 PHE n 
1 377 GLY n 
1 378 LEU n 
1 379 VAL n 
1 380 PRO n 
1 381 GLY n 
1 382 LEU n 
1 383 ASP n 
1 384 PHE n 
1 385 LEU n 
1 386 SER n 
1 387 LYS n 
1 388 ALA n 
1 389 PHE n 
1 390 LYS n 
1 391 GLY n 
1 392 GLN n 
1 393 THR n 
1 394 PRO n 
1 395 LYS n 
1 396 VAL n 
1 397 ALA n 
1 398 CYS n 
1 399 GLY n 
1 400 SER n 
1 401 GLY n 
1 402 VAL n 
1 403 PRO n 
1 404 ALA n 
1 405 ILE n 
1 406 PRO n 
1 407 GLY n 
1 408 ILE n 
1 409 ASN n 
1 410 SER n 
1 411 PRO n 
1 412 SER n 
1 413 THR n 
1 414 GLN n 
1 415 ASN n 
1 416 VAL n 
1 417 LEU n 
1 418 GLY n 
1 419 SER n 
1 420 ASP n 
1 421 LEU n 
1 422 ALA n 
1 423 ASN n 
1 424 GLN n 
1 425 LEU n 
1 426 ASN n 
1 427 SER n 
1 428 LEU n 
1 429 LYS n 
1 430 GLY n 
1 431 GLN n 
1 432 GLN n 
1 433 SER n 
1 434 ALA n 
1 435 PHE n 
1 436 GLY n 
1 437 LYS n 
1 438 PRO n 
1 439 PHE n 
1 440 GLY n 
1 441 SER n 
1 442 VAL n 
1 443 SER n 
1 444 PRO n 
1 445 PRO n 
1 446 LEU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   446 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 UTRI_04204_B 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    'Ustilago trichophora' 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Ustilago trichophora' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     86804 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Komagataella pastoris' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     4922 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               GS115 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          plasmid 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       pFAi2 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking'          y ALANINE                                  ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking'          y ARGININE                                 ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking'          y ASPARAGINE                               ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking'          y 'ASPARTIC ACID'                          ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking'          y CYSTEINE                                 ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking'          y GLUTAMINE                                ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking'          y 'GLUTAMIC ACID'                          ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'            y GLYCINE                                  ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking'          y HISTIDINE                                ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking'          y ISOLEUCINE                               ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking'          y LEUCINE                                  ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking'          y LYSINE                                   ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking'          y METHIONINE                               ? 'C5 H11 N O2 S'  149.211 
NAG 'D-saccharide, beta linking' . 2-acetamido-2-deoxy-beta-D-glucopyranose 
;N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE
;
'C8 H15 N O6'    221.208 
PHE 'L-peptide linking'          y PHENYLALANINE                            ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking'          y PROLINE                                  ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking'          y SERINE                                   ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking'          y THREONINE                                ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking'          y TRYPTOPHAN                               ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking'          y TYROSINE                                 ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking'          y VALINE                                   ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
NAG 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DGlcpNAcb                      
NAG 'COMMON NAME'                         GMML     1.0 N-acetyl-b-D-glucopyranosamine 
NAG 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-GlcpNAc                    
NAG 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 GlcNAc                         
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   VAL 1   13  ?   ?   ?   A . n 
A 1 2   MET 2   14  ?   ?   ?   A . n 
A 1 3   HIS 3   15  ?   ?   ?   A . n 
A 1 4   HIS 4   16  ?   ?   ?   A . n 
A 1 5   HIS 5   17  ?   ?   ?   A . n 
A 1 6   HIS 6   18  ?   ?   ?   A . n 
A 1 7   HIS 7   19  ?   ?   ?   A . n 
A 1 8   HIS 8   20  ?   ?   ?   A . n 
A 1 9   VAL 9   21  ?   ?   ?   A . n 
A 1 10  PRO 10  22  ?   ?   ?   A . n 
A 1 11  MET 11  23  ?   ?   ?   A . n 
A 1 12  GLU 12  24  24  GLU GLU A . n 
A 1 13  ARG 13  25  25  ARG ARG A . n 
A 1 14  ARG 14  26  26  ARG ARG A . n 
A 1 15  ALA 15  27  27  ALA ALA A . n 
A 1 16  PRO 16  28  28  PRO PRO A . n 
A 1 17  PHE 17  29  29  PHE PHE A . n 
A 1 18  PRO 18  30  30  PRO PRO A . n 
A 1 19  ASP 19  31  31  ASP ASP A . n 
A 1 20  PRO 20  32  32  PRO PRO A . n 
A 1 21  ASN 21  33  33  ASN ASN A . n 
A 1 22  ASP 22  34  34  ASP ASP A . n 
A 1 23  ASP 23  35  35  ASP ASP A . n 
A 1 24  PRO 24  36  36  PRO PRO A . n 
A 1 25  PHE 25  37  37  PHE PHE A . n 
A 1 26  TYR 26  38  38  TYR TYR A . n 
A 1 27  LYS 27  39  39  LYS LYS A . n 
A 1 28  THR 28  40  40  THR THR A . n 
A 1 29  PRO 29  41  41  PRO PRO A . n 
A 1 30  SER 30  42  42  SER SER A . n 
A 1 31  ASN 31  43  43  ASN ASN A . n 
A 1 32  ILE 32  44  44  ILE ILE A . n 
A 1 33  GLY 33  45  45  GLY GLY A . n 
A 1 34  THR 34  46  46  THR THR A . n 
A 1 35  TYR 35  47  47  TYR TYR A . n 
A 1 36  ALA 36  48  48  ALA ALA A . n 
A 1 37  ASN 37  49  49  ASN ASN A . n 
A 1 38  GLY 38  50  50  GLY GLY A . n 
A 1 39  GLN 39  51  51  GLN GLN A . n 
A 1 40  VAL 40  52  52  VAL VAL A . n 
A 1 41  ILE 41  53  53  ILE ILE A . n 
A 1 42  GLN 42  54  54  GLN GLN A . n 
A 1 43  SER 43  55  55  SER SER A . n 
A 1 44  ARG 44  56  56  ARG ARG A . n 
A 1 45  LYS 45  57  57  LYS LYS A . n 
A 1 46  ALA 46  58  58  ALA ALA A . n 
A 1 47  PRO 47  59  59  PRO PRO A . n 
A 1 48  THR 48  60  60  THR THR A . n 
A 1 49  ASP 49  61  61  ASP ASP A . n 
A 1 50  ILE 50  62  62  ILE ILE A . n 
A 1 51  GLY 51  63  63  GLY GLY A . n 
A 1 52  ASN 52  64  64  ASN ASN A . n 
A 1 53  GLN 53  65  65  GLN GLN A . n 
A 1 54  ASN 54  66  66  ASN ASN A . n 
A 1 55  GLY 55  67  67  GLY GLY A . n 
A 1 56  ALA 56  68  68  ALA ALA A . n 
A 1 57  ASP 57  69  69  ASP ASP A . n 
A 1 58  SER 58  70  70  SER SER A . n 
A 1 59  PHE 59  71  71  PHE PHE A . n 
A 1 60  GLN 60  72  72  GLN GLN A . n 
A 1 61  LEU 61  73  73  LEU LEU A . n 
A 1 62  SER 62  74  74  SER SER A . n 
A 1 63  TYR 63  75  75  TYR TYR A . n 
A 1 64  ARG 64  76  76  ARG ARG A . n 
A 1 65  THR 65  77  77  THR THR A . n 
A 1 66  THR 66  78  78  THR THR A . n 
A 1 67  ASN 67  79  79  ASN ASN A . n 
A 1 68  THR 68  80  80  THR THR A . n 
A 1 69  GLN 69  81  81  GLN GLN A . n 
A 1 70  LYS 70  82  82  LYS LYS A . n 
A 1 71  GLU 71  83  83  GLU GLU A . n 
A 1 72  ALA 72  84  84  ALA ALA A . n 
A 1 73  GLN 73  85  85  GLN GLN A . n 
A 1 74  ALA 74  86  86  ALA ALA A . n 
A 1 75  ASN 75  87  87  ASN ASN A . n 
A 1 76  VAL 76  88  88  VAL VAL A . n 
A 1 77  ALA 77  89  89  ALA ALA A . n 
A 1 78  THR 78  90  90  THR THR A . n 
A 1 79  VAL 79  91  91  VAL VAL A . n 
A 1 80  PHE 80  92  92  PHE PHE A . n 
A 1 81  ILE 81  93  93  ILE ILE A . n 
A 1 82  PRO 82  94  94  PRO PRO A . n 
A 1 83  SER 83  95  95  SER SER A . n 
A 1 84  LYS 84  96  96  LYS LYS A . n 
A 1 85  PRO 85  97  97  PRO PRO A . n 
A 1 86  ALA 86  98  98  ALA ALA A . n 
A 1 87  SER 87  99  99  SER SER A . n 
A 1 88  PRO 88  100 100 PRO PRO A . n 
A 1 89  PRO 89  101 101 PRO PRO A . n 
A 1 90  LYS 90  102 102 LYS LYS A . n 
A 1 91  ILE 91  103 103 ILE ILE A . n 
A 1 92  PHE 92  104 104 PHE PHE A . n 
A 1 93  SER 93  105 105 SER SER A . n 
A 1 94  TYR 94  106 106 TYR TYR A . n 
A 1 95  GLN 95  107 107 GLN GLN A . n 
A 1 96  VAL 96  108 108 VAL VAL A . n 
A 1 97  TYR 97  109 109 TYR TYR A . n 
A 1 98  GLU 98  110 110 GLU GLU A . n 
A 1 99  ASP 99  111 111 ASP ASP A . n 
A 1 100 SER 100 112 112 SER SER A . n 
A 1 101 THR 101 113 113 THR THR A . n 
A 1 102 GLN 102 114 114 GLN GLN A . n 
A 1 103 LEU 103 115 115 LEU LEU A . n 
A 1 104 ASN 104 116 116 ASN ASN A . n 
A 1 105 CYS 105 117 117 CYS CYS A . n 
A 1 106 ALA 106 118 118 ALA ALA A . n 
A 1 107 PRO 107 119 119 PRO PRO A . n 
A 1 108 SER 108 120 120 SER SER A . n 
A 1 109 TYR 109 121 121 TYR TYR A . n 
A 1 110 SER 110 122 122 SER SER A . n 
A 1 111 TYR 111 123 123 TYR TYR A . n 
A 1 112 LEU 112 124 124 LEU LEU A . n 
A 1 113 THR 113 125 125 THR THR A . n 
A 1 114 GLY 114 126 126 GLY GLY A . n 
A 1 115 PHE 115 127 127 PHE PHE A . n 
A 1 116 ASP 116 128 128 ASP ASP A . n 
A 1 117 GLU 117 129 129 GLU GLU A . n 
A 1 118 PRO 118 130 130 PRO PRO A . n 
A 1 119 ASN 119 131 131 ASN ASN A . n 
A 1 120 LYS 120 132 132 LYS LYS A . n 
A 1 121 VAL 121 133 133 VAL VAL A . n 
A 1 122 THR 122 134 134 THR THR A . n 
A 1 123 THR 123 135 135 THR THR A . n 
A 1 124 VAL 124 136 136 VAL VAL A . n 
A 1 125 LEU 125 137 137 LEU LEU A . n 
A 1 126 ASP 126 138 138 ASP ASP A . n 
A 1 127 THR 127 139 139 THR THR A . n 
A 1 128 PRO 128 140 140 PRO PRO A . n 
A 1 129 ILE 129 141 141 ILE ILE A . n 
A 1 130 ILE 130 142 142 ILE ILE A . n 
A 1 131 ILE 131 143 143 ILE ILE A . n 
A 1 132 SER 132 144 144 SER SER A . n 
A 1 133 TRP 133 145 145 TRP TRP A . n 
A 1 134 ALA 134 146 146 ALA ALA A . n 
A 1 135 LEU 135 147 147 LEU LEU A . n 
A 1 136 GLN 136 148 148 GLN GLN A . n 
A 1 137 GLN 137 149 149 GLN GLN A . n 
A 1 138 GLY 138 150 150 GLY GLY A . n 
A 1 139 TYR 139 151 151 TYR TYR A . n 
A 1 140 TYR 140 152 152 TYR TYR A . n 
A 1 141 VAL 141 153 153 VAL VAL A . n 
A 1 142 VAL 142 154 154 VAL VAL A . n 
A 1 143 SER 143 155 155 SER SER A . n 
A 1 144 SER 144 156 156 SER SER A . n 
A 1 145 ASP 145 157 157 ASP ASP A . n 
A 1 146 HIS 146 158 158 HIS HIS A . n 
A 1 147 GLU 147 159 159 GLU GLU A . n 
A 1 148 GLY 148 160 160 GLY GLY A . n 
A 1 149 PRO 149 161 161 PRO PRO A . n 
A 1 150 ARG 150 162 162 ARG ARG A . n 
A 1 151 SER 151 163 163 SER SER A . n 
A 1 152 ALA 152 164 164 ALA ALA A . n 
A 1 153 PHE 153 165 165 PHE PHE A . n 
A 1 154 ILE 154 166 166 ILE ILE A . n 
A 1 155 ALA 155 167 167 ALA ALA A . n 
A 1 156 GLY 156 168 168 GLY GLY A . n 
A 1 157 TYR 157 169 169 TYR TYR A . n 
A 1 158 GLU 158 170 170 GLU GLU A . n 
A 1 159 GLU 159 171 171 GLU GLU A . n 
A 1 160 GLY 160 172 172 GLY GLY A . n 
A 1 161 MET 161 173 173 MET MET A . n 
A 1 162 ALA 162 174 174 ALA ALA A . n 
A 1 163 ILE 163 175 175 ILE ILE A . n 
A 1 164 LEU 164 176 176 LEU LEU A . n 
A 1 165 ASP 165 177 177 ASP ASP A . n 
A 1 166 GLY 166 178 178 GLY GLY A . n 
A 1 167 ILE 167 179 179 ILE ILE A . n 
A 1 168 ARG 168 180 180 ARG ARG A . n 
A 1 169 ALA 169 181 181 ALA ALA A . n 
A 1 170 PHE 170 182 182 PHE PHE A . n 
A 1 171 LYS 171 183 183 LYS LYS A . n 
A 1 172 ASN 172 184 184 ASN ASN A . n 
A 1 173 PHE 173 185 185 PHE PHE A . n 
A 1 174 LYS 174 186 186 LYS LYS A . n 
A 1 175 ASN 175 187 187 ASN ASN A . n 
A 1 176 LEU 176 188 188 LEU LEU A . n 
A 1 177 PRO 177 189 189 PRO PRO A . n 
A 1 178 GLU 178 190 190 GLU GLU A . n 
A 1 179 ASP 179 191 191 ASP ASP A . n 
A 1 180 ILE 180 192 192 ILE ILE A . n 
A 1 181 GLY 181 193 193 GLY GLY A . n 
A 1 182 VAL 182 194 194 VAL VAL A . n 
A 1 183 GLY 183 195 195 GLY GLY A . n 
A 1 184 PHE 184 196 196 PHE PHE A . n 
A 1 185 TYR 185 197 197 TYR TYR A . n 
A 1 186 GLY 186 198 198 GLY GLY A . n 
A 1 187 TYR 187 199 199 TYR TYR A . n 
A 1 188 SER 188 200 200 SER SER A . n 
A 1 189 GLY 189 201 201 GLY GLY A . n 
A 1 190 GLY 190 202 202 GLY GLY A . n 
A 1 191 ALA 191 203 203 ALA ALA A . n 
A 1 192 HIS 192 204 204 HIS HIS A . n 
A 1 193 ALA 193 205 205 ALA ALA A . n 
A 1 194 THR 194 206 206 THR THR A . n 
A 1 195 ALA 195 207 207 ALA ALA A . n 
A 1 196 TRP 196 208 208 TRP TRP A . n 
A 1 197 ALA 197 209 209 ALA ALA A . n 
A 1 198 VAL 198 210 210 VAL VAL A . n 
A 1 199 SER 199 211 211 SER SER A . n 
A 1 200 LEU 200 212 212 LEU LEU A . n 
A 1 201 ALA 201 213 213 ALA ALA A . n 
A 1 202 GLU 202 214 214 GLU GLU A . n 
A 1 203 GLY 203 215 215 GLY GLY A . n 
A 1 204 TYR 204 216 216 TYR TYR A . n 
A 1 205 ALA 205 217 217 ALA ALA A . n 
A 1 206 PRO 206 218 218 PRO PRO A . n 
A 1 207 GLU 207 219 219 GLU GLU A . n 
A 1 208 ILE 208 220 220 ILE ILE A . n 
A 1 209 LYS 209 221 221 LYS LYS A . n 
A 1 210 ILE 210 222 222 ILE ILE A . n 
A 1 211 ASP 211 223 223 ASP ASP A . n 
A 1 212 GLY 212 224 224 GLY GLY A . n 
A 1 213 ALA 213 225 225 ALA ALA A . n 
A 1 214 ALA 214 226 226 ALA ALA A . n 
A 1 215 TYR 215 227 227 TYR TYR A . n 
A 1 216 GLY 216 228 228 GLY GLY A . n 
A 1 217 GLY 217 229 229 GLY GLY A . n 
A 1 218 THR 218 230 230 THR THR A . n 
A 1 219 PRO 219 231 231 PRO PRO A . n 
A 1 220 ALA 220 232 232 ALA ALA A . n 
A 1 221 SER 221 233 233 SER SER A . n 
A 1 222 ALA 222 234 234 ALA ALA A . n 
A 1 223 LYS 223 235 235 LYS LYS A . n 
A 1 224 ASP 224 236 236 ASP ASP A . n 
A 1 225 THR 225 237 237 THR THR A . n 
A 1 226 PHE 226 238 238 PHE PHE A . n 
A 1 227 THR 227 239 239 THR THR A . n 
A 1 228 PHE 228 240 240 PHE PHE A . n 
A 1 229 LEU 229 241 241 LEU LEU A . n 
A 1 230 ASN 230 242 242 ASN ASN A . n 
A 1 231 LYS 231 243 243 LYS LYS A . n 
A 1 232 GLY 232 244 244 GLY GLY A . n 
A 1 233 PHE 233 245 245 PHE PHE A . n 
A 1 234 PHE 234 246 246 PHE PHE A . n 
A 1 235 ALA 235 247 247 ALA ALA A . n 
A 1 236 GLY 236 248 248 GLY GLY A . n 
A 1 237 PHE 237 249 249 PHE PHE A . n 
A 1 238 ALA 238 250 250 ALA ALA A . n 
A 1 239 VAL 239 251 251 VAL VAL A . n 
A 1 240 ALA 240 252 252 ALA ALA A . n 
A 1 241 GLY 241 253 253 GLY GLY A . n 
A 1 242 VAL 242 254 254 VAL VAL A . n 
A 1 243 SER 243 255 255 SER SER A . n 
A 1 244 GLY 244 256 256 GLY GLY A . n 
A 1 245 LEU 245 257 257 LEU LEU A . n 
A 1 246 ALA 246 258 258 ALA ALA A . n 
A 1 247 LEU 247 259 259 LEU LEU A . n 
A 1 248 ALA 248 260 260 ALA ALA A . n 
A 1 249 HIS 249 261 261 HIS HIS A . n 
A 1 250 PRO 250 262 262 PRO PRO A . n 
A 1 251 ASP 251 263 263 ASP ASP A . n 
A 1 252 MET 252 264 264 MET MET A . n 
A 1 253 GLU 253 265 265 GLU GLU A . n 
A 1 254 ALA 254 266 266 ALA ALA A . n 
A 1 255 PHE 255 267 267 PHE PHE A . n 
A 1 256 LEU 256 268 268 LEU LEU A . n 
A 1 257 GLU 257 269 269 GLU GLU A . n 
A 1 258 PRO 258 270 270 PRO PRO A . n 
A 1 259 ARG 259 271 271 ARG ARG A . n 
A 1 260 LEU 260 272 272 LEU LEU A . n 
A 1 261 ASN 261 273 273 ASN ASN A . n 
A 1 262 ALA 262 274 274 ALA ALA A . n 
A 1 263 LYS 263 275 275 LYS LYS A . n 
A 1 264 GLY 264 276 276 GLY GLY A . n 
A 1 265 LYS 265 277 277 LYS LYS A . n 
A 1 266 GLN 266 278 278 GLN GLN A . n 
A 1 267 VAL 267 279 279 VAL VAL A . n 
A 1 268 PHE 268 280 280 PHE PHE A . n 
A 1 269 GLU 269 281 281 GLU GLU A . n 
A 1 270 GLN 270 282 282 GLN GLN A . n 
A 1 271 ILE 271 283 283 ILE ILE A . n 
A 1 272 ARG 272 284 284 ARG ARG A . n 
A 1 273 SER 273 285 285 SER SER A . n 
A 1 274 ARG 274 286 286 ARG ARG A . n 
A 1 275 GLY 275 287 287 GLY GLY A . n 
A 1 276 PHE 276 288 288 PHE PHE A . n 
A 1 277 CYS 277 289 289 CYS CYS A . n 
A 1 278 LEU 278 290 290 LEU LEU A . n 
A 1 279 PRO 279 291 291 PRO PRO A . n 
A 1 280 SER 280 292 292 SER SER A . n 
A 1 281 VAL 281 293 293 VAL VAL A . n 
A 1 282 VAL 282 294 294 VAL VAL A . n 
A 1 283 LEU 283 295 295 LEU LEU A . n 
A 1 284 HIS 284 296 296 HIS HIS A . n 
A 1 285 ASN 285 297 297 ASN ASN A . n 
A 1 286 ASN 286 298 298 ASN ASN A . n 
A 1 287 PHE 287 299 299 PHE PHE A . n 
A 1 288 VAL 288 300 300 VAL VAL A . n 
A 1 289 ASP 289 301 301 ASP ASP A . n 
A 1 290 VAL 290 302 302 VAL VAL A . n 
A 1 291 PHE 291 303 303 PHE PHE A . n 
A 1 292 SER 292 304 304 SER SER A . n 
A 1 293 LEU 293 305 305 LEU LEU A . n 
A 1 294 VAL 294 306 306 VAL VAL A . n 
A 1 295 ASN 295 307 307 ASN ASN A . n 
A 1 296 ASP 296 308 308 ASP ASP A . n 
A 1 297 THR 297 309 309 THR THR A . n 
A 1 298 ASN 298 310 310 ASN ASN A . n 
A 1 299 LEU 299 311 311 LEU LEU A . n 
A 1 300 LEU 300 312 312 LEU LEU A . n 
A 1 301 ILE 301 313 313 ILE ILE A . n 
A 1 302 GLU 302 314 314 GLU GLU A . n 
A 1 303 GLU 303 315 315 GLU GLU A . n 
A 1 304 PRO 304 316 316 PRO PRO A . n 
A 1 305 ILE 305 317 317 ILE ILE A . n 
A 1 306 ALA 306 318 318 ALA ALA A . n 
A 1 307 GLY 307 319 319 GLY GLY A . n 
A 1 308 ILE 308 320 320 ILE ILE A . n 
A 1 309 LEU 309 321 321 LEU LEU A . n 
A 1 310 LYS 310 322 322 LYS LYS A . n 
A 1 311 GLN 311 323 323 GLN GLN A . n 
A 1 312 GLU 312 324 324 GLU GLU A . n 
A 1 313 THR 313 325 325 THR THR A . n 
A 1 314 LEU 314 326 326 LEU LEU A . n 
A 1 315 VAL 315 327 327 VAL VAL A . n 
A 1 316 GLN 316 328 328 GLN GLN A . n 
A 1 317 ALA 317 329 329 ALA ALA A . n 
A 1 318 GLU 318 330 330 GLU GLU A . n 
A 1 319 ALA 319 331 331 ALA ALA A . n 
A 1 320 SER 320 332 332 SER SER A . n 
A 1 321 TYR 321 333 333 TYR TYR A . n 
A 1 322 THR 322 334 334 THR THR A . n 
A 1 323 VAL 323 335 335 VAL VAL A . n 
A 1 324 PRO 324 336 336 PRO PRO A . n 
A 1 325 VAL 325 337 337 VAL VAL A . n 
A 1 326 PRO 326 338 338 PRO PRO A . n 
A 1 327 LYS 327 339 339 LYS LYS A . n 
A 1 328 PHE 328 340 340 PHE PHE A . n 
A 1 329 PRO 329 341 341 PRO PRO A . n 
A 1 330 ARG 330 342 342 ARG ARG A . n 
A 1 331 PHE 331 343 343 PHE PHE A . n 
A 1 332 MET 332 344 344 MET MET A . n 
A 1 333 TRP 333 345 345 TRP TRP A . n 
A 1 334 HIS 334 346 346 HIS HIS A . n 
A 1 335 ALA 335 347 347 ALA ALA A . n 
A 1 336 LEU 336 348 348 LEU LEU A . n 
A 1 337 PRO 337 349 349 PRO PRO A . n 
A 1 338 ASP 338 350 350 ASP ASP A . n 
A 1 339 GLU 339 351 351 GLU GLU A . n 
A 1 340 ILE 340 352 352 ILE ILE A . n 
A 1 341 VAL 341 353 353 VAL VAL A . n 
A 1 342 PRO 342 354 354 PRO PRO A . n 
A 1 343 PHE 343 355 355 PHE PHE A . n 
A 1 344 GLN 344 356 356 GLN GLN A . n 
A 1 345 PRO 345 357 357 PRO PRO A . n 
A 1 346 ALA 346 358 358 ALA ALA A . n 
A 1 347 ALA 347 359 359 ALA ALA A . n 
A 1 348 ASN 348 360 360 ASN ASN A . n 
A 1 349 TYR 349 361 361 TYR TYR A . n 
A 1 350 VAL 350 362 362 VAL VAL A . n 
A 1 351 LYS 351 363 363 LYS LYS A . n 
A 1 352 GLU 352 364 364 GLU GLU A . n 
A 1 353 GLN 353 365 365 GLN GLN A . n 
A 1 354 CYS 354 366 366 CYS CYS A . n 
A 1 355 GLN 355 367 367 GLN GLN A . n 
A 1 356 LYS 356 368 368 LYS LYS A . n 
A 1 357 GLY 357 369 369 GLY GLY A . n 
A 1 358 ALA 358 370 370 ALA ALA A . n 
A 1 359 ASN 359 371 371 ASN ASN A . n 
A 1 360 ILE 360 372 372 ILE ILE A . n 
A 1 361 ASN 361 373 373 ASN ASN A . n 
A 1 362 TRP 362 374 374 TRP TRP A . n 
A 1 363 ASN 363 375 375 ASN ASN A . n 
A 1 364 VAL 364 376 376 VAL VAL A . n 
A 1 365 TYR 365 377 377 TYR TYR A . n 
A 1 366 PRO 366 378 378 PRO PRO A . n 
A 1 367 ILE 367 379 379 ILE ILE A . n 
A 1 368 ALA 368 380 380 ALA ALA A . n 
A 1 369 GLU 369 381 381 GLU GLU A . n 
A 1 370 HIS 370 382 382 HIS HIS A . n 
A 1 371 VAL 371 383 383 VAL VAL A . n 
A 1 372 THR 372 384 384 THR THR A . n 
A 1 373 ALA 373 385 385 ALA ALA A . n 
A 1 374 GLU 374 386 386 GLU GLU A . n 
A 1 375 ILE 375 387 387 ILE ILE A . n 
A 1 376 PHE 376 388 388 PHE PHE A . n 
A 1 377 GLY 377 389 389 GLY GLY A . n 
A 1 378 LEU 378 390 390 LEU LEU A . n 
A 1 379 VAL 379 391 391 VAL VAL A . n 
A 1 380 PRO 380 392 392 PRO PRO A . n 
A 1 381 GLY 381 393 393 GLY GLY A . n 
A 1 382 LEU 382 394 394 LEU LEU A . n 
A 1 383 ASP 383 395 395 ASP ASP A . n 
A 1 384 PHE 384 396 396 PHE PHE A . n 
A 1 385 LEU 385 397 397 LEU LEU A . n 
A 1 386 SER 386 398 398 SER SER A . n 
A 1 387 LYS 387 399 399 LYS LYS A . n 
A 1 388 ALA 388 400 400 ALA ALA A . n 
A 1 389 PHE 389 401 401 PHE PHE A . n 
A 1 390 LYS 390 402 402 LYS LYS A . n 
A 1 391 GLY 391 403 403 GLY GLY A . n 
A 1 392 GLN 392 404 404 GLN GLN A . n 
A 1 393 THR 393 405 405 THR THR A . n 
A 1 394 PRO 394 406 406 PRO PRO A . n 
A 1 395 LYS 395 407 407 LYS LYS A . n 
A 1 396 VAL 396 408 408 VAL VAL A . n 
A 1 397 ALA 397 409 409 ALA ALA A . n 
A 1 398 CYS 398 410 410 CYS CYS A . n 
A 1 399 GLY 399 411 411 GLY GLY A . n 
A 1 400 SER 400 412 412 SER SER A . n 
A 1 401 GLY 401 413 413 GLY GLY A . n 
A 1 402 VAL 402 414 414 VAL VAL A . n 
A 1 403 PRO 403 415 415 PRO PRO A . n 
A 1 404 ALA 404 416 416 ALA ALA A . n 
A 1 405 ILE 405 417 417 ILE ILE A . n 
A 1 406 PRO 406 418 418 PRO PRO A . n 
A 1 407 GLY 407 419 419 GLY GLY A . n 
A 1 408 ILE 408 420 420 ILE ILE A . n 
A 1 409 ASN 409 421 421 ASN ASN A . n 
A 1 410 SER 410 422 422 SER SER A . n 
A 1 411 PRO 411 423 423 PRO PRO A . n 
A 1 412 SER 412 424 424 SER SER A . n 
A 1 413 THR 413 425 425 THR THR A . n 
A 1 414 GLN 414 426 426 GLN GLN A . n 
A 1 415 ASN 415 427 427 ASN ASN A . n 
A 1 416 VAL 416 428 428 VAL VAL A . n 
A 1 417 LEU 417 429 429 LEU LEU A . n 
A 1 418 GLY 418 430 430 GLY GLY A . n 
A 1 419 SER 419 431 431 SER SER A . n 
A 1 420 ASP 420 432 432 ASP ASP A . n 
A 1 421 LEU 421 433 433 LEU LEU A . n 
A 1 422 ALA 422 434 434 ALA ALA A . n 
A 1 423 ASN 423 435 435 ASN ASN A . n 
A 1 424 GLN 424 436 436 GLN GLN A . n 
A 1 425 LEU 425 437 437 LEU LEU A . n 
A 1 426 ASN 426 438 438 ASN ASN A . n 
A 1 427 SER 427 439 439 SER SER A . n 
A 1 428 LEU 428 440 440 LEU LEU A . n 
A 1 429 LYS 429 441 441 LYS LYS A . n 
A 1 430 GLY 430 442 442 GLY GLY A . n 
A 1 431 GLN 431 443 443 GLN GLN A . n 
A 1 432 GLN 432 444 444 GLN GLN A . n 
A 1 433 SER 433 445 445 SER SER A . n 
A 1 434 ALA 434 446 446 ALA ALA A . n 
A 1 435 PHE 435 447 447 PHE PHE A . n 
A 1 436 GLY 436 448 448 GLY GLY A . n 
A 1 437 LYS 437 449 449 LYS LYS A . n 
A 1 438 PRO 438 450 450 PRO PRO A . n 
A 1 439 PHE 439 451 451 PHE PHE A . n 
A 1 440 GLY 440 452 452 GLY GLY A . n 
A 1 441 SER 441 453 453 SER SER A . n 
A 1 442 VAL 442 454 454 VAL VAL A . n 
A 1 443 SER 443 455 455 SER SER A . n 
A 1 444 PRO 444 456 456 PRO PRO A . n 
A 1 445 PRO 445 457 457 PRO PRO A . n 
A 1 446 LEU 446 458 458 LEU LEU A . n 
# 
_pdbx_nonpoly_scheme.asym_id         B 
_pdbx_nonpoly_scheme.entity_id       2 
_pdbx_nonpoly_scheme.mon_id          NAG 
_pdbx_nonpoly_scheme.ndb_seq_num     1 
_pdbx_nonpoly_scheme.pdb_seq_num     501 
_pdbx_nonpoly_scheme.auth_seq_num    459 
_pdbx_nonpoly_scheme.pdb_mon_id      NAG 
_pdbx_nonpoly_scheme.auth_mon_id     NAG 
_pdbx_nonpoly_scheme.pdb_strand_id   A 
_pdbx_nonpoly_scheme.pdb_ins_code    . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement        ? ? ?                 ?                                       ? ? ? ? ?   ? ? PHENIX      ? ? ?       
1.20.1_4487 1 
? 'data reduction'  ? ? 'Wolfgang Kabsch' Wolfgang.Kabsch@mpimf-heidelberg.mpg.de ? ? ? ? ?   
http://www.mpimf-heidelberg.mpg.de/~kabsch/xds/     ? XDS         ? ? package .           2 
? 'data scaling'    ? ? 'Phil Evans'      ?                                       28/07/21 ? ? ? ?   
http://www.mrc-lmb.cam.ac.uk/harry/pre/aimless.html ? Aimless     ? ? program 0.7.8       3 
? phasing           ? ? 'Randy J. Read'   cimr-phaser@lists.cam.ac.uk             
'Fri Apr 15 19:34:18 2022 (git 1268, 05e3505... )' ? ? ? ?   http://www-structmed.cimr.cam.ac.uk/phaser/         ? PHASER      ? ? 
program 2.8.3       4 
? 'data extraction' ? ? PDB               deposit@deposit.rcsb.org                'Apr. 15, 2021' ? ? ? C++ 
http://sw-tools.pdb.org/apps/PDB_EXTRACT/           ? PDB_EXTRACT ? ? package 3.28        5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9JCA 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     96.730 
_cell.length_a_esd                 ? 
_cell.length_b                     96.730 
_cell.length_b_esd                 ? 
_cell.length_c                     207.397 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        12 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9JCA 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                178 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 61 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9JCA 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.90 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          57.52 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               0.220 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          EVAPORATION 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              5.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.2M Ammonium acetate, 0.1M Sodium citrate tribasic dihydrate pH 5.5, 24% v/v PEG 400' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 X 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-12-09 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.95372 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'AUSTRALIAN SYNCHROTRON BEAMLINE MX1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.95372 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   MX1 
_diffrn_source.pdbx_synchrotron_site       'Australian Synchrotron' 
# 
_reflns.B_iso_Wilson_estimate                          95.490 
_reflns.entry_id                                       9JCA 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              3.330 
_reflns.d_resolution_low                               48.370 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     8996 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.400 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                37.300 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          15.300 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.218 
_reflns.pdbx_Rpim_I_all                                0.035 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       335754 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.216 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
loop_
_reflns_shell.d_res_high 
_reflns_shell.d_res_low 
_reflns_shell.meanI_over_sigI_all 
_reflns_shell.meanI_over_sigI_obs 
_reflns_shell.number_measured_all 
_reflns_shell.number_measured_obs 
_reflns_shell.number_possible 
_reflns_shell.number_unique_all 
_reflns_shell.number_unique_obs 
_reflns_shell.percent_possible_obs 
_reflns_shell.Rmerge_F_all 
_reflns_shell.Rmerge_F_obs 
_reflns_shell.meanI_over_sigI_gt 
_reflns_shell.meanI_over_uI_all 
_reflns_shell.meanI_over_uI_gt 
_reflns_shell.number_measured_gt 
_reflns_shell.number_unique_gt 
_reflns_shell.percent_possible_gt 
_reflns_shell.Rmerge_F_gt 
_reflns_shell.Rmerge_I_gt 
_reflns_shell.pdbx_redundancy 
_reflns_shell.pdbx_chi_squared 
_reflns_shell.pdbx_netI_over_sigmaI_all 
_reflns_shell.pdbx_netI_over_sigmaI_obs 
_reflns_shell.pdbx_Rrim_I_all 
_reflns_shell.pdbx_Rpim_I_all 
_reflns_shell.pdbx_rejects 
_reflns_shell.pdbx_ordinal 
_reflns_shell.pdbx_diffrn_id 
_reflns_shell.pdbx_CC_half 
_reflns_shell.pdbx_CC_star 
_reflns_shell.pdbx_R_split 
_reflns_shell.percent_possible_all 
_reflns_shell.Rmerge_I_all 
_reflns_shell.Rmerge_I_obs 
_reflns_shell.pdbx_Rsym_value 
_reflns_shell.pdbx_percent_possible_ellipsoidal 
_reflns_shell.pdbx_percent_possible_spherical 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous 
_reflns_shell.pdbx_percent_possible_spherical_anomalous 
_reflns_shell.pdbx_redundancy_anomalous 
_reflns_shell.pdbx_CC_half_anomalous 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous 
_reflns_shell.pdbx_percent_possible_anomalous 
3.330 3.590  ? ? 65873 ? ? ? 1737 ? ? ? ? ? ? ? ? ? ? ? 37.900 ? ? 2.600  1.285 0.203 ? 1 1 0.893 ? ? 97.300 ? 1.268 ? ? ? ? ? ? ? 
? ? 
8.800 48.370 ? ? 19594 ? ? ? 581  ? ? ? ? ? ? ? ? ? ? ? 33.700 ? ? 58.000 0.043 0.007 ? 2 1 1.000 ? ? 99.500 ? 0.042 ? ? ? ? ? ? ? 
? ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                160.200 
_refine.B_iso_mean                               88.0899 
_refine.B_iso_min                                52.020 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9JCA 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            3.3300 
_refine.ls_d_res_low                             48.3700 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     8936 
_refine.ls_number_reflns_R_free                  430 
_refine.ls_number_reflns_R_work                  8506 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.6000 
_refine.ls_percent_reflns_R_free                 4.8100 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2247 
_refine.ls_R_factor_R_free                       0.2974 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2210 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.340 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 32.2900 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.5800 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         final 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       3.3300 
_refine_hist.d_res_low                        48.3700 
_refine_hist.number_atoms_solvent             0 
_refine_hist.number_atoms_total               3337 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       435 
_refine_hist.pdbx_B_iso_mean_ligand           101.55 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3323 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         14 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 3.3300 3.8100  2856 . 143 2713 99.0000  . . . 0.0000 0.3196 . . . . . . . 3 . . . 0.4047 
'X-RAY DIFFRACTION' 3.8100 4.8000  2939 . 137 2802 100.0000 . . . 0.0000 0.2343 . . . . . . . 3 . . . 0.3236 
'X-RAY DIFFRACTION' 4.8000 48.3700 3141 . 150 2991 100.0000 . . . 0.0000 0.1821 . . . . . . . 3 . . . 0.2494 
# 
_struct.entry_id                     9JCA 
_struct.title                        'CalA-like lipase from Ustilago trichophora' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9JCA 
_struct_keywords.text            'alpha/beta-Hydrolases, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A0A5C3EAQ1_9BASI 
_struct_ref.pdbx_db_accession          A0A5C3EAQ1 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;VPMERRAPFPDPNDDPFYKTPSNIGTYANGQVIQSRKAPTDIGNQNGADSFQLSYRTTNTQKEAQANVATVFIPSKPASP
PKIFSYQVYEDSTQLNCAPSYSYLTGFDEPNKVTTVLDTPIIISWALQQGYYVVSSDHEGPRSAFIAGYEEGMAILDGIR
AFKNFKNLPEDIGVGFYGYSGGAHATAWAVSLAEGYAPEIKIDGAAYGGTPASAKDTFTFLNKGFFAGFAVAGVSGLALA
HPDMEAFLEPRLNAKGKQVFEQIRSRGFCLPSVVLHNNFVDVFSLVNDTNLLIEEPIAGILKQETLVQAEASYTVPVPKF
PRFMWHALPDEIVPFQPAANYVKEQCQKGANINWNVYPIAEHVTAEIFGLVPGLDFLSKAFKGQTPKVACGSGVPAIPGI
NSPSTQNVLGSDLANQLNSLKGQQSAFGKPFGSVSPPL
;
_struct_ref.pdbx_align_begin           21 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9JCA 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 9 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 446 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             A0A5C3EAQ1 
_struct_ref_seq.db_align_beg                  21 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  458 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       21 
_struct_ref_seq.pdbx_auth_seq_align_end       458 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9JCA VAL A 1 ? UNP A0A5C3EAQ1 ? ? 'expression tag' 13 1 
1 9JCA MET A 2 ? UNP A0A5C3EAQ1 ? ? 'expression tag' 14 2 
1 9JCA HIS A 3 ? UNP A0A5C3EAQ1 ? ? 'expression tag' 15 3 
1 9JCA HIS A 4 ? UNP A0A5C3EAQ1 ? ? 'expression tag' 16 4 
1 9JCA HIS A 5 ? UNP A0A5C3EAQ1 ? ? 'expression tag' 17 5 
1 9JCA HIS A 6 ? UNP A0A5C3EAQ1 ? ? 'expression tag' 18 6 
1 9JCA HIS A 7 ? UNP A0A5C3EAQ1 ? ? 'expression tag' 19 7 
1 9JCA HIS A 8 ? UNP A0A5C3EAQ1 ? ? 'expression tag' 20 8 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 5980  ? 
1 MORE         -48   ? 
1 'SSA (A^2)'  29750 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555  x,y,z        1.0000000000 0.0000000000  0.0000000000 0.0000000000 0.0000000000  1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000   
2 'crystal symmetry operation' 10_554 -y,-x,-z-1/6 0.5000000000 -0.8660254038 0.0000000000 0.0000000000 -0.8660254038 
-0.5000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 -34.5661666667 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 THR A 48  ? ASN A 54  ? THR A 60  ASN A 66  1 ? 7  
HELX_P HELX_P2  AA2 ALA A 106 ? LEU A 112 ? ALA A 118 LEU A 124 1 ? 7  
HELX_P HELX_P3  AA3 ASN A 119 ? LEU A 125 ? ASN A 131 LEU A 137 1 ? 7  
HELX_P HELX_P4  AA4 LEU A 125 ? GLN A 137 ? LEU A 137 GLN A 149 1 ? 13 
HELX_P HELX_P5  AA5 ALA A 155 ? LYS A 174 ? ALA A 167 LYS A 186 1 ? 20 
HELX_P HELX_P6  AA6 SER A 188 ? ALA A 205 ? SER A 200 ALA A 217 1 ? 18 
HELX_P HELX_P7  AA7 SER A 221 ? ASN A 230 ? SER A 233 ASN A 242 1 ? 10 
HELX_P HELX_P8  AA8 PHE A 234 ? HIS A 249 ? PHE A 246 HIS A 261 1 ? 16 
HELX_P HELX_P9  AA9 HIS A 249 ? LEU A 260 ? HIS A 261 LEU A 272 1 ? 12 
HELX_P HELX_P10 AB1 ASN A 261 ? ARG A 272 ? ASN A 273 ARG A 284 1 ? 12 
HELX_P HELX_P11 AB2 CYS A 277 ? HIS A 284 ? CYS A 289 HIS A 296 1 ? 8  
HELX_P HELX_P12 AB3 ASP A 289 ? VAL A 294 ? ASP A 301 VAL A 306 1 ? 6  
HELX_P HELX_P13 AB4 PRO A 304 ? GLU A 312 ? PRO A 316 GLU A 324 1 ? 9  
HELX_P HELX_P14 AB5 PRO A 342 ? LYS A 356 ? PRO A 354 LYS A 368 1 ? 15 
HELX_P HELX_P15 AB6 GLU A 369 ? GLY A 377 ? GLU A 381 GLY A 389 1 ? 9  
HELX_P HELX_P16 AB7 LEU A 378 ? LYS A 390 ? LEU A 390 LYS A 402 1 ? 13 
HELX_P HELX_P17 AB8 SER A 412 ? GLY A 418 ? SER A 424 GLY A 430 1 ? 7  
HELX_P HELX_P18 AB9 GLY A 418 ? LEU A 428 ? GLY A 430 LEU A 440 1 ? 11 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ?   ? A CYS 105 SG  ? ? ? 1_555 A CYS 277 SG ? ? A CYS 117 A CYS 289 1_555 ? ? ? ? ? ? ? 2.023 ? ?               
disulf2 disulf ?   ? A CYS 354 SG  ? ? ? 1_555 A CYS 398 SG ? ? A CYS 366 A CYS 410 1_555 ? ? ? ? ? ? ? 2.022 ? ?               
covale1 covale one ? A ASN 295 ND2 ? ? ? 1_555 B NAG .   C1 ? ? A ASN 307 A NAG 501 1_555 ? ? ? ? ? ? ? 1.440 ? N-Glycosylation 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
covale ? ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 NAG B .   ? ASN A 295 ? NAG A 501 ? 1_555 ASN A 307 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
2 CYS A 105 ? CYS A 277 ? CYS A 117 ? 1_555 CYS A 289 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
3 CYS A 354 ? CYS A 398 ? CYS A 366 ? 1_555 CYS A 410 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 SER 87  A . ? SER 99  A PRO 88  A ? PRO 100 A 1 8.79  
2 GLU 303 A . ? GLU 315 A PRO 304 A ? PRO 316 A 1 17.75 
# 
_struct_sheet.id               AA1 
_struct_sheet.type             ? 
_struct_sheet.number_strands   9 
_struct_sheet.details          ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? parallel      
AA1 5 6 ? parallel      
AA1 6 7 ? parallel      
AA1 7 8 ? parallel      
AA1 8 9 ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 40  ? LYS A 45  ? VAL A 52  LYS A 57  
AA1 2 ASP A 57  ? THR A 66  ? ASP A 69  THR A 78  
AA1 3 ALA A 72  ? ILE A 81  ? ALA A 84  ILE A 93  
AA1 4 TYR A 140 ? SER A 144 ? TYR A 152 SER A 156 
AA1 5 LYS A 90  ? GLN A 95  ? LYS A 102 GLN A 107 
AA1 6 GLY A 181 ? GLY A 186 ? GLY A 193 GLY A 198 
AA1 7 ILE A 210 ? GLY A 216 ? ILE A 222 GLY A 228 
AA1 8 PRO A 329 ? ALA A 335 ? PRO A 341 ALA A 347 
AA1 9 ASN A 359 ? TYR A 365 ? ASN A 371 TYR A 377 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ARG A 44  ? N ARG A 56  O GLN A 60  ? O GLN A 72  
AA1 2 3 N TYR A 63  ? N TYR A 75  O ASN A 75  ? O ASN A 87  
AA1 3 4 N THR A 78  ? N THR A 90  O SER A 143 ? O SER A 155 
AA1 4 5 O TYR A 140 ? O TYR A 152 N PHE A 92  ? N PHE A 104 
AA1 5 6 N ILE A 91  ? N ILE A 103 O GLY A 181 ? O GLY A 193 
AA1 6 7 N PHE A 184 ? N PHE A 196 O ALA A 214 ? O ALA A 226 
AA1 7 8 N TYR A 215 ? N TYR A 227 O PHE A 331 ? O PHE A 343 
AA1 8 9 N ARG A 330 ? N ARG A 342 O ASN A 359 ? O ASN A 371 
# 
_pdbx_entry_details.entry_id                   9JCA 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ARG A 56  ? ? -170.23 146.98  
2  1 LYS A 82  ? ? 60.98   61.22   
3  1 CYS A 117 ? ? -67.76  3.31    
4  1 LEU A 137 ? ? -72.03  -100.10 
5  1 GLN A 148 ? ? -58.46  -6.11   
6  1 ASP A 157 ? ? -64.67  87.16   
7  1 ASN A 187 ? ? 32.82   51.19   
8  1 SER A 200 ? ? 40.38   -117.73 
9  1 ALA A 207 ? ? -35.79  -36.04  
10 1 TYR A 227 ? ? -172.70 148.16  
11 1 GLU A 269 ? ? -28.26  -50.12  
12 1 LEU A 311 ? ? 62.03   -67.16  
13 1 SER A 332 ? ? -84.14  33.93   
14 1 PHE A 340 ? ? -45.41  159.29  
15 1 HIS A 346 ? ? -171.66 126.14  
16 1 PRO A 349 ? ? -93.68  40.57   
17 1 ASP A 350 ? ? -61.75  98.83   
18 1 ASN A 371 ? ? -119.52 74.08   
19 1 PHE A 388 ? ? -43.66  -72.85  
20 1 ALA A 416 ? ? -55.06  106.11  
21 1 ASN A 421 ? ? -161.57 12.82   
22 1 PRO A 423 ? ? -49.28  158.98  
23 1 PRO A 456 ? ? -54.32  172.01  
# 
loop_
_pdbx_validate_planes.id 
_pdbx_validate_planes.PDB_model_num 
_pdbx_validate_planes.auth_comp_id 
_pdbx_validate_planes.auth_asym_id 
_pdbx_validate_planes.auth_seq_id 
_pdbx_validate_planes.PDB_ins_code 
_pdbx_validate_planes.label_alt_id 
_pdbx_validate_planes.rmsd 
_pdbx_validate_planes.type 
1 1 ARG A 162 ? ? 0.255 'SIDE CHAIN' 
2 1 ARG A 180 ? ? 0.248 'SIDE CHAIN' 
# 
_pdbx_phasing_MR.entry_id                     9JCA 
_pdbx_phasing_MR.method_rotation              ? 
_pdbx_phasing_MR.method_translation           ? 
_pdbx_phasing_MR.model_details                'Phaser MODE: MR_AUTO' 
_pdbx_phasing_MR.R_factor                     ? 
_pdbx_phasing_MR.R_rigid_body                 ? 
_pdbx_phasing_MR.correlation_coeff_Fo_to_Fc   ? 
_pdbx_phasing_MR.correlation_coeff_Io_to_Ic   ? 
_pdbx_phasing_MR.d_res_high_rotation          6.520 
_pdbx_phasing_MR.d_res_low_rotation           48.370 
_pdbx_phasing_MR.d_res_high_translation       ? 
_pdbx_phasing_MR.d_res_low_translation        ? 
_pdbx_phasing_MR.packing                      ? 
_pdbx_phasing_MR.reflns_percent_rotation      ? 
_pdbx_phasing_MR.reflns_percent_translation   ? 
_pdbx_phasing_MR.sigma_F_rotation             ? 
_pdbx_phasing_MR.sigma_F_translation          ? 
_pdbx_phasing_MR.sigma_I_rotation             ? 
_pdbx_phasing_MR.sigma_I_translation          ? 
# 
_phasing.method   MR 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A VAL 13 ? A VAL 1  
2  1 Y 1 A MET 14 ? A MET 2  
3  1 Y 1 A HIS 15 ? A HIS 3  
4  1 Y 1 A HIS 16 ? A HIS 4  
5  1 Y 1 A HIS 17 ? A HIS 5  
6  1 Y 1 A HIS 18 ? A HIS 6  
7  1 Y 1 A HIS 19 ? A HIS 7  
8  1 Y 1 A HIS 20 ? A HIS 8  
9  1 Y 1 A VAL 21 ? A VAL 9  
10 1 Y 1 A PRO 22 ? A PRO 10 
11 1 Y 1 A MET 23 ? A MET 11 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
NAG C1   C N R 247 
NAG C2   C N R 248 
NAG C3   C N R 249 
NAG C4   C N S 250 
NAG C5   C N R 251 
NAG C6   C N N 252 
NAG C7   C N N 253 
NAG C8   C N N 254 
NAG N2   N N N 255 
NAG O1   O N N 256 
NAG O3   O N N 257 
NAG O4   O N N 258 
NAG O5   O N N 259 
NAG O6   O N N 260 
NAG O7   O N N 261 
NAG H1   H N N 262 
NAG H2   H N N 263 
NAG H3   H N N 264 
NAG H4   H N N 265 
NAG H5   H N N 266 
NAG H61  H N N 267 
NAG H62  H N N 268 
NAG H81  H N N 269 
NAG H82  H N N 270 
NAG H83  H N N 271 
NAG HN2  H N N 272 
NAG HO1  H N N 273 
NAG HO3  H N N 274 
NAG HO4  H N N 275 
NAG HO6  H N N 276 
PHE N    N N N 277 
PHE CA   C N S 278 
PHE C    C N N 279 
PHE O    O N N 280 
PHE CB   C N N 281 
PHE CG   C Y N 282 
PHE CD1  C Y N 283 
PHE CD2  C Y N 284 
PHE CE1  C Y N 285 
PHE CE2  C Y N 286 
PHE CZ   C Y N 287 
PHE OXT  O N N 288 
PHE H    H N N 289 
PHE H2   H N N 290 
PHE HA   H N N 291 
PHE HB2  H N N 292 
PHE HB3  H N N 293 
PHE HD1  H N N 294 
PHE HD2  H N N 295 
PHE HE1  H N N 296 
PHE HE2  H N N 297 
PHE HZ   H N N 298 
PHE HXT  H N N 299 
PRO N    N N N 300 
PRO CA   C N S 301 
PRO C    C N N 302 
PRO O    O N N 303 
PRO CB   C N N 304 
PRO CG   C N N 305 
PRO CD   C N N 306 
PRO OXT  O N N 307 
PRO H    H N N 308 
PRO HA   H N N 309 
PRO HB2  H N N 310 
PRO HB3  H N N 311 
PRO HG2  H N N 312 
PRO HG3  H N N 313 
PRO HD2  H N N 314 
PRO HD3  H N N 315 
PRO HXT  H N N 316 
SER N    N N N 317 
SER CA   C N S 318 
SER C    C N N 319 
SER O    O N N 320 
SER CB   C N N 321 
SER OG   O N N 322 
SER OXT  O N N 323 
SER H    H N N 324 
SER H2   H N N 325 
SER HA   H N N 326 
SER HB2  H N N 327 
SER HB3  H N N 328 
SER HG   H N N 329 
SER HXT  H N N 330 
THR N    N N N 331 
THR CA   C N S 332 
THR C    C N N 333 
THR O    O N N 334 
THR CB   C N R 335 
THR OG1  O N N 336 
THR CG2  C N N 337 
THR OXT  O N N 338 
THR H    H N N 339 
THR H2   H N N 340 
THR HA   H N N 341 
THR HB   H N N 342 
THR HG1  H N N 343 
THR HG21 H N N 344 
THR HG22 H N N 345 
THR HG23 H N N 346 
THR HXT  H N N 347 
TRP N    N N N 348 
TRP CA   C N S 349 
TRP C    C N N 350 
TRP O    O N N 351 
TRP CB   C N N 352 
TRP CG   C Y N 353 
TRP CD1  C Y N 354 
TRP CD2  C Y N 355 
TRP NE1  N Y N 356 
TRP CE2  C Y N 357 
TRP CE3  C Y N 358 
TRP CZ2  C Y N 359 
TRP CZ3  C Y N 360 
TRP CH2  C Y N 361 
TRP OXT  O N N 362 
TRP H    H N N 363 
TRP H2   H N N 364 
TRP HA   H N N 365 
TRP HB2  H N N 366 
TRP HB3  H N N 367 
TRP HD1  H N N 368 
TRP HE1  H N N 369 
TRP HE3  H N N 370 
TRP HZ2  H N N 371 
TRP HZ3  H N N 372 
TRP HH2  H N N 373 
TRP HXT  H N N 374 
TYR N    N N N 375 
TYR CA   C N S 376 
TYR C    C N N 377 
TYR O    O N N 378 
TYR CB   C N N 379 
TYR CG   C Y N 380 
TYR CD1  C Y N 381 
TYR CD2  C Y N 382 
TYR CE1  C Y N 383 
TYR CE2  C Y N 384 
TYR CZ   C Y N 385 
TYR OH   O N N 386 
TYR OXT  O N N 387 
TYR H    H N N 388 
TYR H2   H N N 389 
TYR HA   H N N 390 
TYR HB2  H N N 391 
TYR HB3  H N N 392 
TYR HD1  H N N 393 
TYR HD2  H N N 394 
TYR HE1  H N N 395 
TYR HE2  H N N 396 
TYR HH   H N N 397 
TYR HXT  H N N 398 
VAL N    N N N 399 
VAL CA   C N S 400 
VAL C    C N N 401 
VAL O    O N N 402 
VAL CB   C N N 403 
VAL CG1  C N N 404 
VAL CG2  C N N 405 
VAL OXT  O N N 406 
VAL H    H N N 407 
VAL H2   H N N 408 
VAL HA   H N N 409 
VAL HB   H N N 410 
VAL HG11 H N N 411 
VAL HG12 H N N 412 
VAL HG13 H N N 413 
VAL HG21 H N N 414 
VAL HG22 H N N 415 
VAL HG23 H N N 416 
VAL HXT  H N N 417 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
NAG C1  C2   sing N N 235 
NAG C1  O1   sing N N 236 
NAG C1  O5   sing N N 237 
NAG C1  H1   sing N N 238 
NAG C2  C3   sing N N 239 
NAG C2  N2   sing N N 240 
NAG C2  H2   sing N N 241 
NAG C3  C4   sing N N 242 
NAG C3  O3   sing N N 243 
NAG C3  H3   sing N N 244 
NAG C4  C5   sing N N 245 
NAG C4  O4   sing N N 246 
NAG C4  H4   sing N N 247 
NAG C5  C6   sing N N 248 
NAG C5  O5   sing N N 249 
NAG C5  H5   sing N N 250 
NAG C6  O6   sing N N 251 
NAG C6  H61  sing N N 252 
NAG C6  H62  sing N N 253 
NAG C7  C8   sing N N 254 
NAG C7  N2   sing N N 255 
NAG C7  O7   doub N N 256 
NAG C8  H81  sing N N 257 
NAG C8  H82  sing N N 258 
NAG C8  H83  sing N N 259 
NAG N2  HN2  sing N N 260 
NAG O1  HO1  sing N N 261 
NAG O3  HO3  sing N N 262 
NAG O4  HO4  sing N N 263 
NAG O6  HO6  sing N N 264 
PHE N   CA   sing N N 265 
PHE N   H    sing N N 266 
PHE N   H2   sing N N 267 
PHE CA  C    sing N N 268 
PHE CA  CB   sing N N 269 
PHE CA  HA   sing N N 270 
PHE C   O    doub N N 271 
PHE C   OXT  sing N N 272 
PHE CB  CG   sing N N 273 
PHE CB  HB2  sing N N 274 
PHE CB  HB3  sing N N 275 
PHE CG  CD1  doub Y N 276 
PHE CG  CD2  sing Y N 277 
PHE CD1 CE1  sing Y N 278 
PHE CD1 HD1  sing N N 279 
PHE CD2 CE2  doub Y N 280 
PHE CD2 HD2  sing N N 281 
PHE CE1 CZ   doub Y N 282 
PHE CE1 HE1  sing N N 283 
PHE CE2 CZ   sing Y N 284 
PHE CE2 HE2  sing N N 285 
PHE CZ  HZ   sing N N 286 
PHE OXT HXT  sing N N 287 
PRO N   CA   sing N N 288 
PRO N   CD   sing N N 289 
PRO N   H    sing N N 290 
PRO CA  C    sing N N 291 
PRO CA  CB   sing N N 292 
PRO CA  HA   sing N N 293 
PRO C   O    doub N N 294 
PRO C   OXT  sing N N 295 
PRO CB  CG   sing N N 296 
PRO CB  HB2  sing N N 297 
PRO CB  HB3  sing N N 298 
PRO CG  CD   sing N N 299 
PRO CG  HG2  sing N N 300 
PRO CG  HG3  sing N N 301 
PRO CD  HD2  sing N N 302 
PRO CD  HD3  sing N N 303 
PRO OXT HXT  sing N N 304 
SER N   CA   sing N N 305 
SER N   H    sing N N 306 
SER N   H2   sing N N 307 
SER CA  C    sing N N 308 
SER CA  CB   sing N N 309 
SER CA  HA   sing N N 310 
SER C   O    doub N N 311 
SER C   OXT  sing N N 312 
SER CB  OG   sing N N 313 
SER CB  HB2  sing N N 314 
SER CB  HB3  sing N N 315 
SER OG  HG   sing N N 316 
SER OXT HXT  sing N N 317 
THR N   CA   sing N N 318 
THR N   H    sing N N 319 
THR N   H2   sing N N 320 
THR CA  C    sing N N 321 
THR CA  CB   sing N N 322 
THR CA  HA   sing N N 323 
THR C   O    doub N N 324 
THR C   OXT  sing N N 325 
THR CB  OG1  sing N N 326 
THR CB  CG2  sing N N 327 
THR CB  HB   sing N N 328 
THR OG1 HG1  sing N N 329 
THR CG2 HG21 sing N N 330 
THR CG2 HG22 sing N N 331 
THR CG2 HG23 sing N N 332 
THR OXT HXT  sing N N 333 
TRP N   CA   sing N N 334 
TRP N   H    sing N N 335 
TRP N   H2   sing N N 336 
TRP CA  C    sing N N 337 
TRP CA  CB   sing N N 338 
TRP CA  HA   sing N N 339 
TRP C   O    doub N N 340 
TRP C   OXT  sing N N 341 
TRP CB  CG   sing N N 342 
TRP CB  HB2  sing N N 343 
TRP CB  HB3  sing N N 344 
TRP CG  CD1  doub Y N 345 
TRP CG  CD2  sing Y N 346 
TRP CD1 NE1  sing Y N 347 
TRP CD1 HD1  sing N N 348 
TRP CD2 CE2  doub Y N 349 
TRP CD2 CE3  sing Y N 350 
TRP NE1 CE2  sing Y N 351 
TRP NE1 HE1  sing N N 352 
TRP CE2 CZ2  sing Y N 353 
TRP CE3 CZ3  doub Y N 354 
TRP CE3 HE3  sing N N 355 
TRP CZ2 CH2  doub Y N 356 
TRP CZ2 HZ2  sing N N 357 
TRP CZ3 CH2  sing Y N 358 
TRP CZ3 HZ3  sing N N 359 
TRP CH2 HH2  sing N N 360 
TRP OXT HXT  sing N N 361 
TYR N   CA   sing N N 362 
TYR N   H    sing N N 363 
TYR N   H2   sing N N 364 
TYR CA  C    sing N N 365 
TYR CA  CB   sing N N 366 
TYR CA  HA   sing N N 367 
TYR C   O    doub N N 368 
TYR C   OXT  sing N N 369 
TYR CB  CG   sing N N 370 
TYR CB  HB2  sing N N 371 
TYR CB  HB3  sing N N 372 
TYR CG  CD1  doub Y N 373 
TYR CG  CD2  sing Y N 374 
TYR CD1 CE1  sing Y N 375 
TYR CD1 HD1  sing N N 376 
TYR CD2 CE2  doub Y N 377 
TYR CD2 HD2  sing N N 378 
TYR CE1 CZ   doub Y N 379 
TYR CE1 HE1  sing N N 380 
TYR CE2 CZ   sing Y N 381 
TYR CE2 HE2  sing N N 382 
TYR CZ  OH   sing N N 383 
TYR OH  HH   sing N N 384 
TYR OXT HXT  sing N N 385 
VAL N   CA   sing N N 386 
VAL N   H    sing N N 387 
VAL N   H2   sing N N 388 
VAL CA  C    sing N N 389 
VAL CA  CB   sing N N 390 
VAL CA  HA   sing N N 391 
VAL C   O    doub N N 392 
VAL C   OXT  sing N N 393 
VAL CB  CG1  sing N N 394 
VAL CB  CG2  sing N N 395 
VAL CB  HB   sing N N 396 
VAL CG1 HG11 sing N N 397 
VAL CG1 HG12 sing N N 398 
VAL CG1 HG13 sing N N 399 
VAL CG2 HG21 sing N N 400 
VAL CG2 HG22 sing N N 401 
VAL CG2 HG23 sing N N 402 
VAL OXT HXT  sing N N 403 
# 
_pdbx_audit_support.funding_organization   'National Research Foundation (NRF, Singapore)' 
_pdbx_audit_support.country                Singapore 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'in silico model' 
_pdbx_initial_refinement_model.source_name      AlphaFold 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9JCA 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.010338 
_atom_sites.fract_transf_matrix[1][2]   0.005969 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.011937 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.004822 
_atom_sites.fract_transf_vector[1]      0.000000 
_atom_sites.fract_transf_vector[2]      0.000000 
_atom_sites.fract_transf_vector[3]      0.000000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . GLU A 1 12  ? 25.873  -63.806 -21.255 1.00 126.25 ? 24  GLU A N   1 
ATOM   2    C CA  . GLU A 1 12  ? 25.570  -65.228 -21.391 1.00 137.25 ? 24  GLU A CA  1 
ATOM   3    C C   . GLU A 1 12  ? 24.740  -65.760 -20.220 1.00 138.14 ? 24  GLU A C   1 
ATOM   4    O O   . GLU A 1 12  ? 24.466  -66.963 -20.134 1.00 136.09 ? 24  GLU A O   1 
ATOM   5    C CB  . GLU A 1 12  ? 26.854  -66.025 -21.506 1.00 144.36 ? 24  GLU A CB  1 
ATOM   6    C CG  . GLU A 1 12  ? 27.637  -65.739 -22.752 1.00 150.09 ? 24  GLU A CG  1 
ATOM   7    C CD  . GLU A 1 12  ? 28.946  -66.505 -22.790 1.00 156.72 ? 24  GLU A CD  1 
ATOM   8    O OE1 . GLU A 1 12  ? 29.298  -67.106 -21.751 1.00 157.18 ? 24  GLU A OE1 1 
ATOM   9    O OE2 . GLU A 1 12  ? 29.628  -66.496 -23.840 1.00 160.20 ? 24  GLU A OE2 1 
ATOM   10   N N   . ARG A 1 13  ? 24.358  -64.852 -19.322 1.00 136.66 ? 25  ARG A N   1 
ATOM   11   C CA  . ARG A 1 13  ? 23.554  -65.164 -18.148 1.00 128.73 ? 25  ARG A CA  1 
ATOM   12   C C   . ARG A 1 13  ? 22.328  -64.267 -18.176 1.00 122.66 ? 25  ARG A C   1 
ATOM   13   O O   . ARG A 1 13  ? 22.295  -63.264 -18.887 1.00 121.64 ? 25  ARG A O   1 
ATOM   14   C CB  . ARG A 1 13  ? 24.311  -64.943 -16.830 1.00 131.82 ? 25  ARG A CB  1 
ATOM   15   C CG  . ARG A 1 13  ? 25.499  -65.860 -16.602 1.00 139.02 ? 25  ARG A CG  1 
ATOM   16   C CD  . ARG A 1 13  ? 26.708  -65.324 -17.357 1.00 142.71 ? 25  ARG A CD  1 
ATOM   17   N NE  . ARG A 1 13  ? 27.886  -66.159 -17.188 1.00 141.88 ? 25  ARG A NE  1 
ATOM   18   C CZ  . ARG A 1 13  ? 28.103  -67.291 -17.839 1.00 149.04 ? 25  ARG A CZ  1 
ATOM   19   N NH1 . ARG A 1 13  ? 27.217  -67.780 -18.692 1.00 150.45 ? 25  ARG A NH1 1 
ATOM   20   N NH2 . ARG A 1 13  ? 29.241  -67.943 -17.635 1.00 153.98 ? 25  ARG A NH2 1 
ATOM   21   N N   . ARG A 1 14  ? 21.334  -64.610 -17.366 1.00 124.37 ? 26  ARG A N   1 
ATOM   22   C CA  . ARG A 1 14  ? 20.027  -63.971 -17.409 1.00 117.63 ? 26  ARG A CA  1 
ATOM   23   C C   . ARG A 1 14  ? 19.745  -63.230 -16.099 1.00 110.91 ? 26  ARG A C   1 
ATOM   24   O O   . ARG A 1 14  ? 20.558  -63.233 -15.172 1.00 112.33 ? 26  ARG A O   1 
ATOM   25   C CB  . ARG A 1 14  ? 18.958  -65.024 -17.691 1.00 116.61 ? 26  ARG A CB  1 
ATOM   26   C CG  . ARG A 1 14  ? 18.598  -65.223 -19.148 1.00 112.11 ? 26  ARG A CG  1 
ATOM   27   C CD  . ARG A 1 14  ? 17.254  -64.597 -19.445 1.00 110.66 ? 26  ARG A CD  1 
ATOM   28   N NE  . ARG A 1 14  ? 17.050  -64.326 -20.864 1.00 111.41 ? 26  ARG A NE  1 
ATOM   29   C CZ  . ARG A 1 14  ? 15.917  -63.867 -21.378 1.00 101.21 ? 26  ARG A CZ  1 
ATOM   30   N NH1 . ARG A 1 14  ? 14.869  -63.617 -20.616 1.00 99.91  ? 26  ARG A NH1 1 
ATOM   31   N NH2 . ARG A 1 14  ? 15.836  -63.646 -22.689 1.00 89.27  ? 26  ARG A NH2 1 
ATOM   32   N N   . ALA A 1 15  ? 18.573  -62.593 -16.033 1.00 109.40 ? 27  ALA A N   1 
ATOM   33   C CA  . ALA A 1 15  ? 18.236  -61.705 -14.927 1.00 107.25 ? 27  ALA A CA  1 
ATOM   34   C C   . ALA A 1 15  ? 18.280  -62.458 -13.598 1.00 106.80 ? 27  ALA A C   1 
ATOM   35   O O   . ALA A 1 15  ? 17.641  -63.510 -13.466 1.00 111.26 ? 27  ALA A O   1 
ATOM   36   C CB  . ALA A 1 15  ? 16.845  -61.100 -15.130 1.00 106.64 ? 27  ALA A CB  1 
ATOM   37   N N   . PRO A 1 16  ? 19.020  -61.971 -12.601 1.00 105.16 ? 28  PRO A N   1 
ATOM   38   C CA  . PRO A 1 16  ? 19.022  -62.650 -11.304 1.00 104.29 ? 28  PRO A CA  1 
ATOM   39   C C   . PRO A 1 16  ? 17.764  -62.442 -10.482 1.00 103.10 ? 28  PRO A C   1 
ATOM   40   O O   . PRO A 1 16  ? 17.678  -62.998 -9.387  1.00 108.60 ? 28  PRO A O   1 
ATOM   41   C CB  . PRO A 1 16  ? 20.250  -62.045 -10.604 1.00 97.96  ? 28  PRO A CB  1 
ATOM   42   C CG  . PRO A 1 16  ? 20.397  -60.711 -11.178 1.00 101.64 ? 28  PRO A CG  1 
ATOM   43   C CD  . PRO A 1 16  ? 19.988  -60.860 -12.630 1.00 106.12 ? 28  PRO A CD  1 
ATOM   44   N N   . PHE A 1 17  ? 16.769  -61.709 -10.952 1.00 96.51  ? 29  PHE A N   1 
ATOM   45   C CA  . PHE A 1 17  ? 15.650  -61.397 -10.078 1.00 104.22 ? 29  PHE A CA  1 
ATOM   46   C C   . PHE A 1 17  ? 14.314  -61.483 -10.806 1.00 104.66 ? 29  PHE A C   1 
ATOM   47   O O   . PHE A 1 17  ? 14.256  -61.341 -12.032 1.00 99.06  ? 29  PHE A O   1 
ATOM   48   C CB  . PHE A 1 17  ? 15.811  -60.002 -9.452  1.00 110.48 ? 29  PHE A CB  1 
ATOM   49   C CG  . PHE A 1 17  ? 16.521  -59.997 -8.106  1.00 112.57 ? 29  PHE A CG  1 
ATOM   50   C CD1 . PHE A 1 17  ? 16.567  -61.139 -7.314  1.00 110.79 ? 29  PHE A CD1 1 
ATOM   51   C CD2 . PHE A 1 17  ? 17.163  -58.849 -7.652  1.00 105.36 ? 29  PHE A CD2 1 
ATOM   52   C CE1 . PHE A 1 17  ? 17.219  -61.118 -6.084  1.00 106.99 ? 29  PHE A CE1 1 
ATOM   53   C CE2 . PHE A 1 17  ? 17.818  -58.824 -6.440  1.00 95.80  ? 29  PHE A CE2 1 
ATOM   54   C CZ  . PHE A 1 17  ? 17.849  -59.952 -5.651  1.00 99.99  ? 29  PHE A CZ  1 
ATOM   55   N N   . PRO A 1 18  ? 13.224  -61.728 -10.059 1.00 102.00 ? 30  PRO A N   1 
ATOM   56   C CA  . PRO A 1 18  ? 11.879  -61.493 -10.599 1.00 97.05  ? 30  PRO A CA  1 
ATOM   57   C C   . PRO A 1 18  ? 11.696  -60.044 -10.986 1.00 103.86 ? 30  PRO A C   1 
ATOM   58   O O   . PRO A 1 18  ? 12.143  -59.136 -10.287 1.00 108.88 ? 30  PRO A O   1 
ATOM   59   C CB  . PRO A 1 18  ? 10.952  -61.848 -9.429  1.00 97.71  ? 30  PRO A CB  1 
ATOM   60   C CG  . PRO A 1 18  ? 11.782  -61.738 -8.223  1.00 101.50 ? 30  PRO A CG  1 
ATOM   61   C CD  . PRO A 1 18  ? 13.174  -62.164 -8.654  1.00 104.73 ? 30  PRO A CD  1 
ATOM   62   N N   . ASP A 1 19  ? 11.013  -59.838 -12.092 1.00 103.97 ? 31  ASP A N   1 
ATOM   63   C CA  . ASP A 1 19  ? 10.641  -58.492 -12.489 1.00 100.00 ? 31  ASP A CA  1 
ATOM   64   C C   . ASP A 1 19  ? 9.997   -57.749 -11.323 1.00 99.86  ? 31  ASP A C   1 
ATOM   65   O O   . ASP A 1 19  ? 9.233   -58.342 -10.548 1.00 98.38  ? 31  ASP A O   1 
ATOM   66   C CB  . ASP A 1 19  ? 9.714   -58.547 -13.707 1.00 100.13 ? 31  ASP A CB  1 
ATOM   67   C CG  . ASP A 1 19  ? 9.109   -57.205 -14.064 1.00 99.72  ? 31  ASP A CG  1 
ATOM   68   O OD1 . ASP A 1 19  ? 9.262   -56.781 -15.226 1.00 103.90 ? 31  ASP A OD1 1 
ATOM   69   O OD2 . ASP A 1 19  ? 8.378   -56.633 -13.227 1.00 96.31  ? 31  ASP A OD2 1 
ATOM   70   N N   . PRO A 1 20  ? 10.306  -56.458 -11.170 1.00 105.27 ? 32  PRO A N   1 
ATOM   71   C CA  . PRO A 1 20  ? 9.762   -55.650 -10.060 1.00 99.69  ? 32  PRO A CA  1 
ATOM   72   C C   . PRO A 1 20  ? 8.250   -55.697 -9.847  1.00 103.35 ? 32  PRO A C   1 
ATOM   73   O O   . PRO A 1 20  ? 7.835   -55.770 -8.682  1.00 104.37 ? 32  PRO A O   1 
ATOM   74   C CB  . PRO A 1 20  ? 10.259  -54.239 -10.416 1.00 94.06  ? 32  PRO A CB  1 
ATOM   75   C CG  . PRO A 1 20  ? 11.526  -54.500 -11.233 1.00 99.49  ? 32  PRO A CG  1 
ATOM   76   C CD  . PRO A 1 20  ? 11.200  -55.679 -12.049 1.00 105.54 ? 32  PRO A CD  1 
ATOM   77   N N   . ASN A 1 21  ? 7.411   -55.624 -10.887 1.00 104.46 ? 33  ASN A N   1 
ATOM   78   C CA  . ASN A 1 21  ? 5.978   -55.774 -10.642 1.00 95.52  ? 33  ASN A CA  1 
ATOM   79   C C   . ASN A 1 21  ? 5.718   -57.037 -9.842  1.00 100.89 ? 33  ASN A C   1 
ATOM   80   O O   . ASN A 1 21  ? 5.031   -57.008 -8.814  1.00 98.90  ? 33  ASN A O   1 
ATOM   81   C CB  . ASN A 1 21  ? 5.181   -55.802 -11.950 1.00 94.00  ? 33  ASN A CB  1 
ATOM   82   C CG  . ASN A 1 21  ? 5.591   -54.708 -12.940 1.00 97.78  ? 33  ASN A CG  1 
ATOM   83   O OD1 . ASN A 1 21  ? 4.942   -53.660 -13.037 1.00 98.32  ? 33  ASN A OD1 1 
ATOM   84   N ND2 . ASN A 1 21  ? 6.669   -54.948 -13.678 1.00 100.98 ? 33  ASN A ND2 1 
ATOM   85   N N   . ASP A 1 22  ? 6.342   -58.142 -10.269 1.00 104.83 ? 34  ASP A N   1 
ATOM   86   C CA  . ASP A 1 22  ? 6.122   -59.449 -9.661  1.00 103.85 ? 34  ASP A CA  1 
ATOM   87   C C   . ASP A 1 22  ? 6.764   -59.544 -8.279  1.00 106.54 ? 34  ASP A C   1 
ATOM   88   O O   . ASP A 1 22  ? 6.133   -60.033 -7.334  1.00 107.21 ? 34  ASP A O   1 
ATOM   89   C CB  . ASP A 1 22  ? 6.653   -60.543 -10.593 1.00 102.55 ? 34  ASP A CB  1 
ATOM   90   C CG  . ASP A 1 22  ? 6.155   -60.386 -12.035 1.00 102.79 ? 34  ASP A CG  1 
ATOM   91   O OD1 . ASP A 1 22  ? 5.185   -59.631 -12.272 1.00 100.71 ? 34  ASP A OD1 1 
ATOM   92   O OD2 . ASP A 1 22  ? 6.728   -61.030 -12.939 1.00 100.07 ? 34  ASP A OD2 1 
ATOM   93   N N   . ASP A 1 23  ? 8.004   -59.074 -8.136  1.00 107.82 ? 35  ASP A N   1 
ATOM   94   C CA  . ASP A 1 23  ? 8.689   -59.109 -6.846  1.00 103.01 ? 35  ASP A CA  1 
ATOM   95   C C   . ASP A 1 23  ? 7.877   -58.377 -5.771  1.00 99.93  ? 35  ASP A C   1 
ATOM   96   O O   . ASP A 1 23  ? 7.362   -57.281 -6.020  1.00 104.46 ? 35  ASP A O   1 
ATOM   97   C CB  . ASP A 1 23  ? 10.062  -58.462 -6.980  1.00 97.51  ? 35  ASP A CB  1 
ATOM   98   C CG  . ASP A 1 23  ? 11.056  -59.016 -6.016  1.00 97.24  ? 35  ASP A CG  1 
ATOM   99   O OD1 . ASP A 1 23  ? 10.763  -59.098 -4.807  1.00 95.48  ? 35  ASP A OD1 1 
ATOM   100  O OD2 . ASP A 1 23  ? 12.166  -59.323 -6.470  1.00 100.90 ? 35  ASP A OD2 1 
ATOM   101  N N   . PRO A 1 24  ? 7.730   -58.950 -4.561  1.00 96.16  ? 36  PRO A N   1 
ATOM   102  C CA  . PRO A 1 24  ? 6.907   -58.297 -3.534  1.00 97.23  ? 36  PRO A CA  1 
ATOM   103  C C   . PRO A 1 24  ? 7.686   -57.173 -2.884  1.00 96.94  ? 36  PRO A C   1 
ATOM   104  O O   . PRO A 1 24  ? 7.126   -56.171 -2.421  1.00 91.99  ? 36  PRO A O   1 
ATOM   105  C CB  . PRO A 1 24  ? 6.657   -59.417 -2.524  1.00 99.98  ? 36  PRO A CB  1 
ATOM   106  C CG  . PRO A 1 24  ? 6.883   -60.657 -3.282  1.00 103.68 ? 36  PRO A CG  1 
ATOM   107  C CD  . PRO A 1 24  ? 8.037   -60.333 -4.180  1.00 100.96 ? 36  PRO A CD  1 
ATOM   108  N N   . PHE A 1 25  ? 9.006   -57.352 -2.797  1.00 99.69  ? 37  PHE A N   1 
ATOM   109  C CA  . PHE A 1 25  ? 9.878   -56.324 -2.170  1.00 99.59  ? 37  PHE A CA  1 
ATOM   110  C C   . PHE A 1 25  ? 9.437   -54.952 -2.626  1.00 100.94 ? 37  PHE A C   1 
ATOM   111  O O   . PHE A 1 25  ? 9.290   -54.038 -1.788  1.00 108.56 ? 37  PHE A O   1 
ATOM   112  C CB  . PHE A 1 25  ? 11.292  -56.631 -2.664  1.00 97.34  ? 37  PHE A CB  1 
ATOM   113  C CG  . PHE A 1 25  ? 12.467  -56.056 -1.884  1.00 101.97 ? 37  PHE A CG  1 
ATOM   114  C CD1 . PHE A 1 25  ? 12.762  -56.498 -0.601  1.00 98.92  ? 37  PHE A CD1 1 
ATOM   115  C CD2 . PHE A 1 25  ? 13.303  -55.104 -2.457  1.00 102.64 ? 37  PHE A CD2 1 
ATOM   116  C CE1 . PHE A 1 25  ? 13.844  -55.983 0.095   1.00 92.47  ? 37  PHE A CE1 1 
ATOM   117  C CE2 . PHE A 1 25  ? 14.385  -54.596 -1.758  1.00 92.20  ? 37  PHE A CE2 1 
ATOM   118  C CZ  . PHE A 1 25  ? 14.652  -55.035 -0.484  1.00 92.97  ? 37  PHE A CZ  1 
ATOM   119  N N   . TYR A 1 26  ? 9.177   -54.806 -3.925  1.00 93.97  ? 38  TYR A N   1 
ATOM   120  C CA  . TYR A 1 26  ? 8.834   -53.469 -4.478  1.00 87.76  ? 38  TYR A CA  1 
ATOM   121  C C   . TYR A 1 26  ? 7.457   -53.015 -3.984  1.00 93.00  ? 38  TYR A C   1 
ATOM   122  O O   . TYR A 1 26  ? 7.242   -51.790 -3.879  1.00 103.57 ? 38  TYR A O   1 
ATOM   123  C CB  . TYR A 1 26  ? 8.936   -53.565 -6.002  1.00 81.79  ? 38  TYR A CB  1 
ATOM   124  C CG  . TYR A 1 26  ? 10.357  -53.688 -6.535  1.00 85.97  ? 38  TYR A CG  1 
ATOM   125  C CD1 . TYR A 1 26  ? 11.022  -54.909 -6.543  1.00 95.64  ? 38  TYR A CD1 1 
ATOM   126  C CD2 . TYR A 1 26  ? 11.034  -52.581 -7.031  1.00 88.14  ? 38  TYR A CD2 1 
ATOM   127  C CE1 . TYR A 1 26  ? 12.314  -55.024 -7.026  1.00 94.00  ? 38  TYR A CE1 1 
ATOM   128  C CE2 . TYR A 1 26  ? 12.326  -52.683 -7.518  1.00 93.43  ? 38  TYR A CE2 1 
ATOM   129  C CZ  . TYR A 1 26  ? 12.968  -53.908 -7.516  1.00 94.85  ? 38  TYR A CZ  1 
ATOM   130  O OH  . TYR A 1 26  ? 14.242  -54.011 -7.995  1.00 102.33 ? 38  TYR A OH  1 
ATOM   131  N N   . LYS A 1 27  ? 6.554   -53.952 -3.685  1.00 93.30  ? 39  LYS A N   1 
ATOM   132  C CA  . LYS A 1 27  ? 5.167   -53.569 -3.297  1.00 101.79 ? 39  LYS A CA  1 
ATOM   133  C C   . LYS A 1 27  ? 5.178   -52.789 -1.971  1.00 97.39  ? 39  LYS A C   1 
ATOM   134  O O   . LYS A 1 27  ? 5.971   -53.150 -1.074  1.00 99.97  ? 39  LYS A O   1 
ATOM   135  C CB  . LYS A 1 27  ? 4.279   -54.818 -3.219  1.00 105.46 ? 39  LYS A CB  1 
ATOM   136  C CG  . LYS A 1 27  ? 3.998   -55.539 -4.531  1.00 102.19 ? 39  LYS A CG  1 
ATOM   137  C CD  . LYS A 1 27  ? 3.131   -56.780 -4.363  1.00 100.73 ? 39  LYS A CD  1 
ATOM   138  C CE  . LYS A 1 27  ? 2.838   -57.472 -5.656  1.00 101.76 ? 39  LYS A CE  1 
ATOM   139  N NZ  . LYS A 1 27  ? 2.023   -58.674 -5.466  1.00 99.29  ? 39  LYS A NZ  1 
ATOM   140  N N   . THR A 1 28  ? 4.345   -51.747 -1.868  1.00 92.30  ? 40  THR A N   1 
ATOM   141  C CA  . THR A 1 28  ? 4.250   -50.967 -0.615  1.00 87.56  ? 40  THR A CA  1 
ATOM   142  C C   . THR A 1 28  ? 3.555   -51.785 0.452   1.00 88.87  ? 40  THR A C   1 
ATOM   143  O O   . THR A 1 28  ? 2.514   -52.400 0.144   1.00 89.98  ? 40  THR A O   1 
ATOM   144  C CB  . THR A 1 28  ? 3.518   -49.660 -0.918  1.00 92.27  ? 40  THR A CB  1 
ATOM   145  O OG1 . THR A 1 28  ? 4.459   -48.876 -1.644  1.00 95.99  ? 40  THR A OG1 1 
ATOM   146  C CG2 . THR A 1 28  ? 3.091   -48.911 0.330   1.00 86.29  ? 40  THR A CG2 1 
ATOM   147  N N   . PRO A 1 29  ? 4.067   -51.820 1.700   1.00 89.58  ? 41  PRO A N   1 
ATOM   148  C CA  . PRO A 1 29  ? 3.400   -52.501 2.805   1.00 88.18  ? 41  PRO A CA  1 
ATOM   149  C C   . PRO A 1 29  ? 2.171   -51.826 3.401   1.00 86.92  ? 41  PRO A C   1 
ATOM   150  O O   . PRO A 1 29  ? 2.014   -50.606 3.246   1.00 89.53  ? 41  PRO A O   1 
ATOM   151  C CB  . PRO A 1 29  ? 4.521   -52.649 3.848   1.00 87.65  ? 41  PRO A CB  1 
ATOM   152  C CG  . PRO A 1 29  ? 5.421   -51.476 3.583   1.00 94.02  ? 41  PRO A CG  1 
ATOM   153  C CD  . PRO A 1 29  ? 5.344   -51.257 2.086   1.00 94.64  ? 41  PRO A CD  1 
ATOM   154  N N   . SER A 1 30  ? 1.321   -52.586 4.093   1.00 93.24  ? 42  SER A N   1 
ATOM   155  C CA  . SER A 1 30  ? 0.160   -51.965 4.783   1.00 99.53  ? 42  SER A CA  1 
ATOM   156  C C   . SER A 1 30  ? 0.666   -51.251 6.041   1.00 98.56  ? 42  SER A C   1 
ATOM   157  O O   . SER A 1 30  ? -0.105  -50.464 6.626   1.00 98.77  ? 42  SER A O   1 
ATOM   158  C CB  . SER A 1 30  ? -0.870  -52.997 5.132   1.00 100.45 ? 42  SER A CB  1 
ATOM   159  O OG  . SER A 1 30  ? -0.390  -53.850 6.162   1.00 102.39 ? 42  SER A OG  1 
ATOM   160  N N   . ASN A 1 31  ? 1.915   -51.512 6.426   1.00 103.08 ? 43  ASN A N   1 
ATOM   161  C CA  . ASN A 1 31  ? 2.518   -50.913 7.650   1.00 101.08 ? 43  ASN A CA  1 
ATOM   162  C C   . ASN A 1 31  ? 3.347   -49.698 7.234   1.00 99.50  ? 43  ASN A C   1 
ATOM   163  O O   . ASN A 1 31  ? 4.066   -49.152 8.092   1.00 104.78 ? 43  ASN A O   1 
ATOM   164  C CB  . ASN A 1 31  ? 3.322   -51.940 8.437   1.00 97.26  ? 43  ASN A CB  1 
ATOM   165  C CG  . ASN A 1 31  ? 3.282   -53.304 7.792   1.00 106.99 ? 43  ASN A CG  1 
ATOM   166  O OD1 . ASN A 1 31  ? 4.158   -53.636 6.986   1.00 103.70 ? 43  ASN A OD1 1 
ATOM   167  N ND2 . ASN A 1 31  ? 2.282   -54.105 8.130   1.00 109.12 ? 43  ASN A ND2 1 
ATOM   168  N N   . ILE A 1 32  ? 3.245   -49.282 5.973   1.00 96.97  ? 44  ILE A N   1 
ATOM   169  C CA  . ILE A 1 32  ? 4.127   -48.196 5.452   1.00 95.97  ? 44  ILE A CA  1 
ATOM   170  C C   . ILE A 1 32  ? 3.890   -46.904 6.253   1.00 98.56  ? 44  ILE A C   1 
ATOM   171  O O   . ILE A 1 32  ? 4.883   -46.204 6.537   1.00 93.04  ? 44  ILE A O   1 
ATOM   172  C CB  . ILE A 1 32  ? 3.907   -48.009 3.940   1.00 94.58  ? 44  ILE A CB  1 
ATOM   173  C CG1 . ILE A 1 32  ? 5.057   -47.242 3.315   1.00 85.57  ? 44  ILE A CG1 1 
ATOM   174  C CG2 . ILE A 1 32  ? 2.552   -47.370 3.634   1.00 89.25  ? 44  ILE A CG2 1 
ATOM   175  C CD1 . ILE A 1 32  ? 6.388   -47.950 3.464   1.00 82.06  ? 44  ILE A CD1 1 
ATOM   176  N N   . GLY A 1 33  ? 2.642   -46.609 6.616   1.00 106.59 ? 45  GLY A N   1 
ATOM   177  C CA  . GLY A 1 33  ? 2.353   -45.383 7.378   1.00 105.23 ? 45  GLY A CA  1 
ATOM   178  C C   . GLY A 1 33  ? 3.068   -45.428 8.712   1.00 97.63  ? 45  GLY A C   1 
ATOM   179  O O   . GLY A 1 33  ? 3.604   -44.382 9.129   1.00 94.84  ? 45  GLY A O   1 
ATOM   180  N N   . THR A 1 34  ? 3.091   -46.596 9.357   1.00 100.63 ? 46  THR A N   1 
ATOM   181  C CA  . THR A 1 34  ? 3.816   -46.750 10.636  1.00 101.48 ? 46  THR A CA  1 
ATOM   182  C C   . THR A 1 34  ? 5.293   -46.507 10.406  1.00 98.01  ? 46  THR A C   1 
ATOM   183  O O   . THR A 1 34  ? 5.923   -45.866 11.272  1.00 101.30 ? 46  THR A O   1 
ATOM   184  C CB  . THR A 1 34  ? 3.556   -48.138 11.216  1.00 99.03  ? 46  THR A CB  1 
ATOM   185  O OG1 . THR A 1 34  ? 4.532   -48.991 10.625  1.00 104.57 ? 46  THR A OG1 1 
ATOM   186  C CG2 . THR A 1 34  ? 2.163   -48.648 10.897  1.00 93.86  ? 46  THR A CG2 1 
ATOM   187  N N   . TYR A 1 35  ? 5.842   -46.997 9.292   1.00 98.20  ? 47  TYR A N   1 
ATOM   188  C CA  . TYR A 1 35  ? 7.310   -46.879 9.083   1.00 99.91  ? 47  TYR A CA  1 
ATOM   189  C C   . TYR A 1 35  ? 7.700   -45.411 8.980   1.00 103.69 ? 47  TYR A C   1 
ATOM   190  O O   . TYR A 1 35  ? 6.987   -44.628 8.318   1.00 102.25 ? 47  TYR A O   1 
ATOM   191  C CB  . TYR A 1 35  ? 7.742   -47.647 7.832   1.00 95.80  ? 47  TYR A CB  1 
ATOM   192  C CG  . TYR A 1 35  ? 7.447   -49.137 7.907   1.00 101.18 ? 47  TYR A CG  1 
ATOM   193  C CD1 . TYR A 1 35  ? 6.882   -49.811 6.834   1.00 102.19 ? 47  TYR A CD1 1 
ATOM   194  C CD2 . TYR A 1 35  ? 7.726   -49.864 9.055   1.00 97.83  ? 47  TYR A CD2 1 
ATOM   195  C CE1 . TYR A 1 35  ? 6.599   -51.163 6.902   1.00 102.43 ? 47  TYR A CE1 1 
ATOM   196  C CE2 . TYR A 1 35  ? 7.456   -51.220 9.133   1.00 105.56 ? 47  TYR A CE2 1 
ATOM   197  C CZ  . TYR A 1 35  ? 6.893   -51.871 8.052   1.00 109.56 ? 47  TYR A CZ  1 
ATOM   198  O OH  . TYR A 1 35  ? 6.624   -53.207 8.120   1.00 110.47 ? 47  TYR A OH  1 
ATOM   199  N N   . ALA A 1 36  ? 8.822   -45.050 9.605   1.00 104.76 ? 48  ALA A N   1 
ATOM   200  C CA  . ALA A 1 36  ? 9.328   -43.657 9.571   1.00 95.76  ? 48  ALA A CA  1 
ATOM   201  C C   . ALA A 1 36  ? 9.894   -43.331 8.189   1.00 93.90  ? 48  ALA A C   1 
ATOM   202  O O   . ALA A 1 36  ? 10.293  -44.257 7.457   1.00 92.14  ? 48  ALA A O   1 
ATOM   203  C CB  . ALA A 1 36  ? 10.366  -43.462 10.651  1.00 102.00 ? 48  ALA A CB  1 
ATOM   204  N N   . ASN A 1 37  ? 9.922   -42.046 7.838   1.00 95.29  ? 49  ASN A N   1 
ATOM   205  C CA  . ASN A 1 37  ? 10.524  -41.644 6.540   1.00 98.17  ? 49  ASN A CA  1 
ATOM   206  C C   . ASN A 1 37  ? 12.012  -42.000 6.564   1.00 94.06  ? 49  ASN A C   1 
ATOM   207  O O   . ASN A 1 37  ? 12.644  -41.841 7.629   1.00 94.44  ? 49  ASN A O   1 
ATOM   208  C CB  . ASN A 1 37  ? 10.283  -40.169 6.243   1.00 102.06 ? 49  ASN A CB  1 
ATOM   209  C CG  . ASN A 1 37  ? 9.134   -39.970 5.287   1.00 104.56 ? 49  ASN A CG  1 
ATOM   210  O OD1 . ASN A 1 37  ? 9.214   -40.382 4.125   1.00 99.93  ? 49  ASN A OD1 1 
ATOM   211  N ND2 . ASN A 1 37  ? 8.062   -39.343 5.748   1.00 106.62 ? 49  ASN A ND2 1 
ATOM   212  N N   . GLY A 1 38  ? 12.546  -42.470 5.435   1.00 92.75  ? 50  GLY A N   1 
ATOM   213  C CA  . GLY A 1 38  ? 13.956  -42.900 5.380   1.00 91.92  ? 50  GLY A CA  1 
ATOM   214  C C   . GLY A 1 38  ? 14.231  -44.024 6.358   1.00 94.78  ? 50  GLY A C   1 
ATOM   215  O O   . GLY A 1 38  ? 15.347  -44.056 6.907   1.00 91.63  ? 50  GLY A O   1 
ATOM   216  N N   . GLN A 1 39  ? 13.266  -44.926 6.552   1.00 88.34  ? 51  GLN A N   1 
ATOM   217  C CA  . GLN A 1 39  ? 13.464  -46.112 7.427   1.00 85.85  ? 51  GLN A CA  1 
ATOM   218  C C   . GLN A 1 39  ? 13.332  -47.341 6.521   1.00 93.92  ? 51  GLN A C   1 
ATOM   219  O O   . GLN A 1 39  ? 12.409  -47.352 5.677   1.00 94.33  ? 51  GLN A O   1 
ATOM   220  C CB  . GLN A 1 39  ? 12.494  -46.154 8.609   1.00 87.65  ? 51  GLN A CB  1 
ATOM   221  C CG  . GLN A 1 39  ? 12.755  -47.274 9.610   1.00 93.28  ? 51  GLN A CG  1 
ATOM   222  C CD  . GLN A 1 39  ? 11.890  -47.191 10.848  1.00 100.19 ? 51  GLN A CD  1 
ATOM   223  O OE1 . GLN A 1 39  ? 11.128  -46.239 11.042  1.00 95.14  ? 51  GLN A OE1 1 
ATOM   224  N NE2 . GLN A 1 39  ? 12.001  -48.198 11.702  1.00 109.78 ? 51  GLN A NE2 1 
ATOM   225  N N   . VAL A 1 40  ? 14.246  -48.305 6.637   1.00 96.85  ? 52  VAL A N   1 
ATOM   226  C CA  . VAL A 1 40  ? 14.193  -49.435 5.666   1.00 95.65  ? 52  VAL A CA  1 
ATOM   227  C C   . VAL A 1 40  ? 13.226  -50.501 6.193   1.00 96.20  ? 52  VAL A C   1 
ATOM   228  O O   . VAL A 1 40  ? 13.476  -51.039 7.291   1.00 90.71  ? 52  VAL A O   1 
ATOM   229  C CB  . VAL A 1 40  ? 15.604  -50.018 5.466   1.00 90.46  ? 52  VAL A CB  1 
ATOM   230  C CG1 . VAL A 1 40  ? 15.865  -50.374 4.011   1.00 93.53  ? 52  VAL A CG1 1 
ATOM   231  C CG2 . VAL A 1 40  ? 16.685  -49.078 5.987   1.00 92.47  ? 52  VAL A CG2 1 
ATOM   232  N N   . ILE A 1 41  ? 12.173  -50.791 5.426   1.00 98.65  ? 53  ILE A N   1 
ATOM   233  C CA  . ILE A 1 41  ? 11.219  -51.872 5.805   1.00 101.65 ? 53  ILE A CA  1 
ATOM   234  C C   . ILE A 1 41  ? 11.991  -53.193 5.787   1.00 96.77  ? 53  ILE A C   1 
ATOM   235  O O   . ILE A 1 41  ? 11.799  -54.006 6.716   1.00 100.46 ? 53  ILE A O   1 
ATOM   236  C CB  . ILE A 1 41  ? 10.054  -51.913 4.803   1.00 100.99 ? 53  ILE A CB  1 
ATOM   237  C CG1 . ILE A 1 41  ? 9.459   -50.526 4.580   1.00 95.85  ? 53  ILE A CG1 1 
ATOM   238  C CG2 . ILE A 1 41  ? 8.997   -52.935 5.222   1.00 89.37  ? 53  ILE A CG2 1 
ATOM   239  C CD1 . ILE A 1 41  ? 9.238   -50.190 3.118   1.00 83.10  ? 53  ILE A CD1 1 
ATOM   240  N N   . GLN A 1 42  ? 12.849  -53.370 4.778   1.00 87.03  ? 54  GLN A N   1 
ATOM   241  C CA  . GLN A 1 42  ? 13.586  -54.647 4.623   1.00 90.70  ? 54  GLN A CA  1 
ATOM   242  C C   . GLN A 1 42  ? 14.718  -54.457 3.612   1.00 92.21  ? 54  GLN A C   1 
ATOM   243  O O   . GLN A 1 42  ? 14.820  -53.353 3.036   1.00 94.16  ? 54  GLN A O   1 
ATOM   244  C CB  . GLN A 1 42  ? 12.643  -55.729 4.102   1.00 102.02 ? 54  GLN A CB  1 
ATOM   245  C CG  . GLN A 1 42  ? 11.674  -55.230 3.037   1.00 107.02 ? 54  GLN A CG  1 
ATOM   246  C CD  . GLN A 1 42  ? 10.962  -56.343 2.303   1.00 109.17 ? 54  GLN A CD  1 
ATOM   247  O OE1 . GLN A 1 42  ? 11.298  -57.524 2.439   1.00 103.75 ? 54  GLN A OE1 1 
ATOM   248  N NE2 . GLN A 1 42  ? 9.968   -55.972 1.509   1.00 108.95 ? 54  GLN A NE2 1 
ATOM   249  N N   . SER A 1 43  ? 15.512  -55.504 3.387   1.00 86.46  ? 55  SER A N   1 
ATOM   250  C CA  . SER A 1 43  ? 16.635  -55.413 2.468   1.00 89.15  ? 55  SER A CA  1 
ATOM   251  C C   . SER A 1 43  ? 17.037  -56.809 2.013   1.00 95.25  ? 55  SER A C   1 
ATOM   252  O O   . SER A 1 43  ? 16.468  -57.812 2.450   1.00 95.75  ? 55  SER A O   1 
ATOM   253  C CB  . SER A 1 43  ? 17.817  -54.737 3.129   1.00 88.61  ? 55  SER A CB  1 
ATOM   254  O OG  . SER A 1 43  ? 18.624  -55.742 3.701   1.00 92.09  ? 55  SER A OG  1 
ATOM   255  N N   . ARG A 1 44  ? 18.064  -56.862 1.163   1.00 87.67  ? 56  ARG A N   1 
ATOM   256  C CA  . ARG A 1 44  ? 18.556  -58.086 0.543   1.00 85.51  ? 56  ARG A CA  1 
ATOM   257  C C   . ARG A 1 44  ? 19.866  -57.804 -0.163  1.00 87.21  ? 56  ARG A C   1 
ATOM   258  O O   . ARG A 1 44  ? 20.052  -56.721 -0.720  1.00 90.09  ? 56  ARG A O   1 
ATOM   259  C CB  . ARG A 1 44  ? 17.567  -58.665 -0.477  1.00 93.83  ? 56  ARG A CB  1 
ATOM   260  C CG  . ARG A 1 44  ? 17.047  -57.693 -1.553  1.00 95.44  ? 56  ARG A CG  1 
ATOM   261  C CD  . ARG A 1 44  ? 16.296  -58.455 -2.650  1.00 94.61  ? 56  ARG A CD  1 
ATOM   262  N NE  . ARG A 1 44  ? 15.198  -57.726 -3.278  1.00 96.44  ? 56  ARG A NE  1 
ATOM   263  C CZ  . ARG A 1 44  ? 14.554  -58.149 -4.358  1.00 98.59  ? 56  ARG A CZ  1 
ATOM   264  N NH1 . ARG A 1 44  ? 14.942  -59.229 -5.009  1.00 103.02 ? 56  ARG A NH1 1 
ATOM   265  N NH2 . ARG A 1 44  ? 13.509  -57.461 -4.811  1.00 93.47  ? 56  ARG A NH2 1 
ATOM   266  N N   . LYS A 1 45  ? 20.752  -58.801 -0.178  1.00 83.31  ? 57  LYS A N   1 
ATOM   267  C CA  . LYS A 1 45  ? 21.905  -58.733 -1.064  1.00 84.90  ? 57  LYS A CA  1 
ATOM   268  C C   . LYS A 1 45  ? 21.413  -58.508 -2.493  1.00 82.98  ? 57  LYS A C   1 
ATOM   269  O O   . LYS A 1 45  ? 20.231  -58.689 -2.793  1.00 82.98  ? 57  LYS A O   1 
ATOM   270  C CB  . LYS A 1 45  ? 22.710  -60.021 -0.991  1.00 93.03  ? 57  LYS A CB  1 
ATOM   271  C CG  . LYS A 1 45  ? 24.045  -59.948 -1.706  1.00 92.92  ? 57  LYS A CG  1 
ATOM   272  C CD  . LYS A 1 45  ? 25.037  -60.780 -0.949  1.00 97.58  ? 57  LYS A CD  1 
ATOM   273  C CE  . LYS A 1 45  ? 26.420  -60.214 -1.033  1.00 102.26 ? 57  LYS A CE  1 
ATOM   274  N NZ  . LYS A 1 45  ? 27.290  -60.858 -0.002  1.00 106.64 ? 57  LYS A NZ  1 
ATOM   275  N N   . ALA A 1 46  ? 22.316  -58.102 -3.382  1.00 79.64  ? 58  ALA A N   1 
ATOM   276  C CA  . ALA A 1 46  ? 21.862  -57.831 -4.742  1.00 84.98  ? 58  ALA A CA  1 
ATOM   277  C C   . ALA A 1 46  ? 22.994  -57.786 -5.765  1.00 92.90  ? 58  ALA A C   1 
ATOM   278  O O   . ALA A 1 46  ? 23.883  -56.926 -5.681  1.00 92.76  ? 58  ALA A O   1 
ATOM   279  C CB  . ALA A 1 46  ? 21.080  -56.519 -4.787  1.00 89.03  ? 58  ALA A CB  1 
ATOM   280  N N   . PRO A 1 47  ? 22.938  -58.660 -6.777  1.00 95.56  ? 59  PRO A N   1 
ATOM   281  C CA  . PRO A 1 47  ? 24.068  -58.850 -7.718  1.00 100.23 ? 59  PRO A CA  1 
ATOM   282  C C   . PRO A 1 47  ? 24.194  -57.743 -8.758  1.00 103.12 ? 59  PRO A C   1 
ATOM   283  O O   . PRO A 1 47  ? 23.291  -57.557 -9.574  1.00 112.86 ? 59  PRO A O   1 
ATOM   284  C CB  . PRO A 1 47  ? 23.718  -60.175 -8.405  1.00 93.90  ? 59  PRO A CB  1 
ATOM   285  C CG  . PRO A 1 47  ? 22.674  -60.811 -7.513  1.00 89.46  ? 59  PRO A CG  1 
ATOM   286  C CD  . PRO A 1 47  ? 21.924  -59.719 -6.891  1.00 85.64  ? 59  PRO A CD  1 
ATOM   287  N N   . THR A 1 48  ? 25.352  -57.074 -8.804  1.00 95.94  ? 60  THR A N   1 
ATOM   288  C CA  . THR A 1 48  ? 25.508  -55.922 -9.690  1.00 101.84 ? 60  THR A CA  1 
ATOM   289  C C   . THR A 1 48  ? 26.772  -56.027 -10.529 1.00 94.71  ? 60  THR A C   1 
ATOM   290  O O   . THR A 1 48  ? 27.862  -56.196 -9.984  1.00 97.34  ? 60  THR A O   1 
ATOM   291  C CB  . THR A 1 48  ? 25.541  -54.622 -8.883  1.00 104.47 ? 60  THR A CB  1 
ATOM   292  O OG1 . THR A 1 48  ? 26.474  -54.759 -7.809  1.00 104.86 ? 60  THR A OG1 1 
ATOM   293  C CG2 . THR A 1 48  ? 24.168  -54.336 -8.290  1.00 96.27  ? 60  THR A CG2 1 
ATOM   294  N N   . ASP A 1 49  ? 26.627  -55.878 -11.848 1.00 94.73  ? 61  ASP A N   1 
ATOM   295  C CA  . ASP A 1 49  ? 27.794  -55.796 -12.724 1.00 103.88 ? 61  ASP A CA  1 
ATOM   296  C C   . ASP A 1 49  ? 28.807  -54.795 -12.187 1.00 106.90 ? 61  ASP A C   1 
ATOM   297  O O   . ASP A 1 49  ? 29.990  -55.115 -12.021 1.00 106.74 ? 61  ASP A O   1 
ATOM   298  C CB  . ASP A 1 49  ? 27.372  -55.398 -14.141 1.00 108.08 ? 61  ASP A CB  1 
ATOM   299  C CG  . ASP A 1 49  ? 26.611  -56.486 -14.843 1.00 107.74 ? 61  ASP A CG  1 
ATOM   300  O OD1 . ASP A 1 49  ? 27.209  -57.551 -15.066 1.00 116.13 ? 61  ASP A OD1 1 
ATOM   301  O OD2 . ASP A 1 49  ? 25.420  -56.288 -15.158 1.00 100.01 ? 61  ASP A OD2 1 
ATOM   302  N N   . ILE A 1 50  ? 28.346  -53.573 -11.900 1.00 112.03 ? 62  ILE A N   1 
ATOM   303  C CA  . ILE A 1 50  ? 29.205  -52.543 -11.315 1.00 107.71 ? 62  ILE A CA  1 
ATOM   304  C C   . ILE A 1 50  ? 29.757  -53.021 -9.976  1.00 104.16 ? 62  ILE A C   1 
ATOM   305  O O   . ILE A 1 50  ? 30.971  -53.005 -9.745  1.00 106.47 ? 62  ILE A O   1 
ATOM   306  C CB  . ILE A 1 50  ? 28.423  -51.226 -11.154 1.00 105.61 ? 62  ILE A CB  1 
ATOM   307  C CG1 . ILE A 1 50  ? 27.753  -50.833 -12.472 1.00 102.76 ? 62  ILE A CG1 1 
ATOM   308  C CG2 . ILE A 1 50  ? 29.354  -50.125 -10.704 1.00 96.83  ? 62  ILE A CG2 1 
ATOM   309  C CD1 . ILE A 1 50  ? 27.494  -49.353 -12.612 1.00 89.78  ? 62  ILE A CD1 1 
ATOM   310  N N   . GLY A 1 51  ? 28.872  -53.450 -9.073  1.00 95.34  ? 63  GLY A N   1 
ATOM   311  C CA  . GLY A 1 51  ? 29.330  -53.957 -7.789  1.00 97.41  ? 63  GLY A CA  1 
ATOM   312  C C   . GLY A 1 51  ? 30.383  -55.038 -7.920  1.00 97.59  ? 63  GLY A C   1 
ATOM   313  O O   . GLY A 1 51  ? 31.274  -55.159 -7.081  1.00 97.54  ? 63  GLY A O   1 
ATOM   314  N N   . ASN A 1 52  ? 30.300  -55.838 -8.974  1.00 98.28  ? 64  ASN A N   1 
ATOM   315  C CA  . ASN A 1 52  ? 31.336  -56.833 -9.195  1.00 97.08  ? 64  ASN A CA  1 
ATOM   316  C C   . ASN A 1 52  ? 32.622  -56.178 -9.633  1.00 99.00  ? 64  ASN A C   1 
ATOM   317  O O   . ASN A 1 52  ? 33.662  -56.372 -9.002  1.00 109.81 ? 64  ASN A O   1 
ATOM   318  C CB  . ASN A 1 52  ? 30.889  -57.856 -10.229 1.00 106.02 ? 64  ASN A CB  1 
ATOM   319  C CG  . ASN A 1 52  ? 29.613  -58.541 -9.838  1.00 107.37 ? 64  ASN A CG  1 
ATOM   320  O OD1 . ASN A 1 52  ? 29.392  -58.842 -8.660  1.00 100.12 ? 64  ASN A OD1 1 
ATOM   321  N ND2 . ASN A 1 52  ? 28.734  -58.745 -10.810 1.00 112.33 ? 64  ASN A ND2 1 
ATOM   322  N N   . GLN A 1 53  ? 32.570  -55.390 -10.710 1.00 98.35  ? 65  GLN A N   1 
ATOM   323  C CA  . GLN A 1 53  ? 33.784  -54.788 -11.251 1.00 100.72 ? 65  GLN A CA  1 
ATOM   324  C C   . GLN A 1 53  ? 34.629  -54.142 -10.162 1.00 103.62 ? 65  GLN A C   1 
ATOM   325  O O   . GLN A 1 53  ? 35.855  -54.079 -10.293 1.00 101.81 ? 65  GLN A O   1 
ATOM   326  C CB  . GLN A 1 53  ? 33.438  -53.747 -12.313 1.00 106.04 ? 65  GLN A CB  1 
ATOM   327  C CG  . GLN A 1 53  ? 32.660  -54.292 -13.486 1.00 113.99 ? 65  GLN A CG  1 
ATOM   328  C CD  . GLN A 1 53  ? 31.633  -53.282 -14.000 1.00 124.54 ? 65  GLN A CD  1 
ATOM   329  O OE1 . GLN A 1 53  ? 31.726  -52.074 -13.717 1.00 120.62 ? 65  GLN A OE1 1 
ATOM   330  N NE2 . GLN A 1 53  ? 30.630  -53.777 -14.735 1.00 119.53 ? 65  GLN A NE2 1 
ATOM   331  N N   . ASN A 1 54  ? 34.002  -53.707 -9.062  1.00 102.13 ? 66  ASN A N   1 
ATOM   332  C CA  . ASN A 1 54  ? 34.671  -52.977 -7.995  1.00 98.40  ? 66  ASN A CA  1 
ATOM   333  C C   . ASN A 1 54  ? 34.768  -53.757 -6.681  1.00 95.59  ? 66  ASN A C   1 
ATOM   334  O O   . ASN A 1 54  ? 35.130  -53.173 -5.659  1.00 98.65  ? 66  ASN A O   1 
ATOM   335  C CB  . ASN A 1 54  ? 33.979  -51.614 -7.769  1.00 96.61  ? 66  ASN A CB  1 
ATOM   336  C CG  . ASN A 1 54  ? 33.639  -50.862 -9.087  1.00 98.99  ? 66  ASN A CG  1 
ATOM   337  O OD1 . ASN A 1 54  ? 32.577  -50.236 -9.209  1.00 99.26  ? 66  ASN A OD1 1 
ATOM   338  N ND2 . ASN A 1 54  ? 34.552  -50.904 -10.052 1.00 99.47  ? 66  ASN A ND2 1 
ATOM   339  N N   . GLY A 1 55  ? 34.485  -55.058 -6.683  1.00 99.09  ? 67  GLY A N   1 
ATOM   340  C CA  . GLY A 1 55  ? 34.585  -55.839 -5.456  1.00 92.96  ? 67  GLY A CA  1 
ATOM   341  C C   . GLY A 1 55  ? 33.689  -55.371 -4.341  1.00 83.18  ? 67  GLY A C   1 
ATOM   342  O O   . GLY A 1 55  ? 33.878  -55.755 -3.189  1.00 79.97  ? 67  GLY A O   1 
ATOM   343  N N   . ALA A 1 56  ? 32.701  -54.553 -4.662  1.00 92.51  ? 68  ALA A N   1 
ATOM   344  C CA  . ALA A 1 56  ? 31.927  -53.813 -3.682  1.00 93.87  ? 68  ALA A CA  1 
ATOM   345  C C   . ALA A 1 56  ? 30.567  -54.460 -3.474  1.00 96.26  ? 68  ALA A C   1 
ATOM   346  O O   . ALA A 1 56  ? 29.802  -54.666 -4.429  1.00 93.96  ? 68  ALA A O   1 
ATOM   347  C CB  . ALA A 1 56  ? 31.756  -52.360 -4.114  1.00 93.84  ? 68  ALA A CB  1 
ATOM   348  N N   . ASP A 1 57  ? 30.265  -54.754 -2.219  1.00 93.09  ? 69  ASP A N   1 
ATOM   349  C CA  . ASP A 1 57  ? 29.022  -55.424 -1.892  1.00 95.54  ? 69  ASP A CA  1 
ATOM   350  C C   . ASP A 1 57  ? 27.848  -54.547 -2.288  1.00 94.82  ? 69  ASP A C   1 
ATOM   351  O O   . ASP A 1 57  ? 27.797  -53.372 -1.927  1.00 102.59 ? 69  ASP A O   1 
ATOM   352  C CB  . ASP A 1 57  ? 29.003  -55.722 -0.405  1.00 98.62  ? 69  ASP A CB  1 
ATOM   353  C CG  . ASP A 1 57  ? 29.183  -57.189 -0.121  1.00 106.25 ? 69  ASP A CG  1 
ATOM   354  O OD1 . ASP A 1 57  ? 29.665  -57.912 -1.029  1.00 102.08 ? 69  ASP A OD1 1 
ATOM   355  O OD2 . ASP A 1 57  ? 28.886  -57.609 1.014   1.00 107.92 ? 69  ASP A OD2 1 
ATOM   356  N N   . SER A 1 58  ? 26.914  -55.100 -3.051  1.00 94.50  ? 70  SER A N   1 
ATOM   357  C CA  . SER A 1 58  ? 25.752  -54.342 -3.490  1.00 91.89  ? 70  SER A CA  1 
ATOM   358  C C   . SER A 1 58  ? 24.505  -54.903 -2.849  1.00 83.63  ? 70  SER A C   1 
ATOM   359  O O   . SER A 1 58  ? 24.340  -56.120 -2.762  1.00 93.81  ? 70  SER A O   1 
ATOM   360  C CB  . SER A 1 58  ? 25.582  -54.368 -4.996  1.00 96.56  ? 70  SER A CB  1 
ATOM   361  O OG  . SER A 1 58  ? 25.772  -55.673 -5.503  1.00 99.83  ? 70  SER A OG  1 
ATOM   362  N N   . PHE A 1 59  ? 23.622  -54.011 -2.433  1.00 80.64  ? 71  PHE A N   1 
ATOM   363  C CA  . PHE A 1 59  ? 22.402  -54.388 -1.736  1.00 88.97  ? 71  PHE A CA  1 
ATOM   364  C C   . PHE A 1 59  ? 21.189  -53.651 -2.293  1.00 89.25  ? 71  PHE A C   1 
ATOM   365  O O   . PHE A 1 59  ? 21.306  -52.719 -3.090  1.00 92.26  ? 71  PHE A O   1 
ATOM   366  C CB  . PHE A 1 59  ? 22.539  -54.105 -0.247  1.00 95.94  ? 71  PHE A CB  1 
ATOM   367  C CG  . PHE A 1 59  ? 23.367  -55.104 0.456   1.00 99.34  ? 71  PHE A CG  1 
ATOM   368  C CD1 . PHE A 1 59  ? 24.752  -55.054 0.364   1.00 102.85 ? 71  PHE A CD1 1 
ATOM   369  C CD2 . PHE A 1 59  ? 22.767  -56.096 1.216   1.00 101.89 ? 71  PHE A CD2 1 
ATOM   370  C CE1 . PHE A 1 59  ? 25.520  -55.990 1.003   1.00 105.29 ? 71  PHE A CE1 1 
ATOM   371  C CE2 . PHE A 1 59  ? 23.517  -57.038 1.865   1.00 104.67 ? 71  PHE A CE2 1 
ATOM   372  C CZ  . PHE A 1 59  ? 24.900  -56.989 1.758   1.00 113.49 ? 71  PHE A CZ  1 
ATOM   373  N N   . GLN A 1 60  ? 20.011  -54.069 -1.850  1.00 85.68  ? 72  GLN A N   1 
ATOM   374  C CA  . GLN A 1 60  ? 18.765  -53.420 -2.222  1.00 93.43  ? 72  GLN A CA  1 
ATOM   375  C C   . GLN A 1 60  ? 17.988  -53.100 -0.956  1.00 89.39  ? 72  GLN A C   1 
ATOM   376  O O   . GLN A 1 60  ? 17.877  -53.939 -0.055  1.00 86.90  ? 72  GLN A O   1 
ATOM   377  C CB  . GLN A 1 60  ? 17.924  -54.313 -3.139  1.00 97.93  ? 72  GLN A CB  1 
ATOM   378  C CG  . GLN A 1 60  ? 18.077  -54.005 -4.610  1.00 95.27  ? 72  GLN A CG  1 
ATOM   379  C CD  . GLN A 1 60  ? 17.034  -54.706 -5.412  1.00 96.85  ? 72  GLN A CD  1 
ATOM   380  O OE1 . GLN A 1 60  ? 15.965  -55.023 -4.883  1.00 97.51  ? 72  GLN A OE1 1 
ATOM   381  N NE2 . GLN A 1 60  ? 17.319  -54.946 -6.701  1.00 96.72  ? 72  GLN A NE2 1 
ATOM   382  N N   . LEU A 1 61  ? 17.463  -51.884 -0.876  1.00 82.71  ? 73  LEU A N   1 
ATOM   383  C CA  . LEU A 1 61  ? 16.859  -51.413 0.360   1.00 87.23  ? 73  LEU A CA  1 
ATOM   384  C C   . LEU A 1 61  ? 15.429  -51.010 0.061   1.00 82.11  ? 73  LEU A C   1 
ATOM   385  O O   . LEU A 1 61  ? 15.190  -50.076 -0.705  1.00 82.64  ? 73  LEU A O   1 
ATOM   386  C CB  . LEU A 1 61  ? 17.653  -50.250 0.951   1.00 95.62  ? 73  LEU A CB  1 
ATOM   387  C CG  . LEU A 1 61  ? 19.188  -50.236 0.786   1.00 91.94  ? 73  LEU A CG  1 
ATOM   388  C CD1 . LEU A 1 61  ? 19.787  -49.095 1.557   1.00 95.96  ? 73  LEU A CD1 1 
ATOM   389  C CD2 . LEU A 1 61  ? 19.855  -51.506 1.217   1.00 96.42  ? 73  LEU A CD2 1 
ATOM   390  N N   . SER A 1 62  ? 14.485  -51.720 0.650   1.00 83.80  ? 74  SER A N   1 
ATOM   391  C CA  . SER A 1 62  ? 13.080  -51.366 0.536   1.00 87.30  ? 74  SER A CA  1 
ATOM   392  C C   . SER A 1 62  ? 12.755  -50.470 1.729   1.00 89.81  ? 74  SER A C   1 
ATOM   393  O O   . SER A 1 62  ? 12.748  -50.921 2.881   1.00 89.19  ? 74  SER A O   1 
ATOM   394  C CB  . SER A 1 62  ? 12.207  -52.618 0.480   1.00 90.84  ? 74  SER A CB  1 
ATOM   395  O OG  . SER A 1 62  ? 10.912  -52.370 0.987   1.00 97.40  ? 74  SER A OG  1 
ATOM   396  N N   . TYR A 1 63  ? 12.521  -49.192 1.453   1.00 86.95  ? 75  TYR A N   1 
ATOM   397  C CA  . TYR A 1 63  ? 12.481  -48.165 2.480   1.00 83.39  ? 75  TYR A CA  1 
ATOM   398  C C   . TYR A 1 63  ? 11.255  -47.289 2.327   1.00 78.48  ? 75  TYR A C   1 
ATOM   399  O O   . TYR A 1 63  ? 10.890  -46.904 1.216   1.00 80.85  ? 75  TYR A O   1 
ATOM   400  C CB  . TYR A 1 63  ? 13.739  -47.307 2.413   1.00 85.53  ? 75  TYR A CB  1 
ATOM   401  C CG  . TYR A 1 63  ? 13.874  -46.430 1.183   1.00 80.73  ? 75  TYR A CG  1 
ATOM   402  C CD1 . TYR A 1 63  ? 13.162  -45.223 1.052   1.00 74.79  ? 75  TYR A CD1 1 
ATOM   403  C CD2 . TYR A 1 63  ? 14.737  -46.803 0.161   1.00 79.00  ? 75  TYR A CD2 1 
ATOM   404  C CE1 . TYR A 1 63  ? 13.300  -44.435 -0.061  1.00 73.24  ? 75  TYR A CE1 1 
ATOM   405  C CE2 . TYR A 1 63  ? 14.891  -46.020 -0.958  1.00 79.36  ? 75  TYR A CE2 1 
ATOM   406  C CZ  . TYR A 1 63  ? 14.175  -44.839 -1.066  1.00 79.56  ? 75  TYR A CZ  1 
ATOM   407  O OH  . TYR A 1 63  ? 14.356  -44.086 -2.198  1.00 82.09  ? 75  TYR A OH  1 
ATOM   408  N N   . ARG A 1 64  ? 10.633  -46.962 3.446   1.00 77.48  ? 76  ARG A N   1 
ATOM   409  C CA  . ARG A 1 64  ? 9.545   -46.009 3.401   1.00 81.17  ? 76  ARG A CA  1 
ATOM   410  C C   . ARG A 1 64  ? 10.028  -44.672 2.848   1.00 86.08  ? 76  ARG A C   1 
ATOM   411  O O   . ARG A 1 64  ? 11.164  -44.255 3.061   1.00 87.36  ? 76  ARG A O   1 
ATOM   412  C CB  . ARG A 1 64  ? 8.940   -45.835 4.787   1.00 83.17  ? 76  ARG A CB  1 
ATOM   413  C CG  . ARG A 1 64  ? 7.707   -44.982 4.783   1.00 89.52  ? 76  ARG A CG  1 
ATOM   414  C CD  . ARG A 1 64  ? 8.086   -43.514 4.999   1.00 92.30  ? 76  ARG A CD  1 
ATOM   415  N NE  . ARG A 1 64  ? 7.057   -42.586 4.557   1.00 86.08  ? 76  ARG A NE  1 
ATOM   416  C CZ  . ARG A 1 64  ? 6.112   -42.084 5.335   1.00 89.55  ? 76  ARG A CZ  1 
ATOM   417  N NH1 . ARG A 1 64  ? 6.003   -42.426 6.607   1.00 90.23  ? 76  ARG A NH1 1 
ATOM   418  N NH2 . ARG A 1 64  ? 5.262   -41.206 4.827   1.00 100.26 ? 76  ARG A NH2 1 
ATOM   419  N N   . THR A 1 65  ? 9.137   -43.999 2.133   1.00 85.71  ? 77  THR A N   1 
ATOM   420  C CA  . THR A 1 65  ? 9.350   -42.642 1.641   1.00 84.31  ? 77  THR A CA  1 
ATOM   421  C C   . THR A 1 65  ? 8.016   -41.916 1.550   1.00 89.22  ? 77  THR A C   1 
ATOM   422  O O   . THR A 1 65  ? 7.020   -42.335 2.154   1.00 86.28  ? 77  THR A O   1 
ATOM   423  C CB  . THR A 1 65  ? 10.064  -42.636 0.284   1.00 83.85  ? 77  THR A CB  1 
ATOM   424  O OG1 . THR A 1 65  ? 10.140  -41.278 -0.186  1.00 80.72  ? 77  THR A OG1 1 
ATOM   425  C CG2 . THR A 1 65  ? 9.341   -43.515 -0.713  1.00 83.34  ? 77  THR A CG2 1 
ATOM   426  N N   . THR A 1 66  ? 8.008   -40.820 0.780   1.00 87.60  ? 78  THR A N   1 
ATOM   427  C CA  . THR A 1 66  ? 6.798   -40.059 0.522   1.00 92.59  ? 78  THR A CA  1 
ATOM   428  C C   . THR A 1 66  ? 6.680   -39.713 -0.958  1.00 89.52  ? 78  THR A C   1 
ATOM   429  O O   . THR A 1 66  ? 7.673   -39.444 -1.647  1.00 81.40  ? 78  THR A O   1 
ATOM   430  C CB  . THR A 1 66  ? 6.738   -38.792 1.374   1.00 88.53  ? 78  THR A CB  1 
ATOM   431  O OG1 . THR A 1 66  ? 6.713   -39.161 2.756   1.00 87.69  ? 78  THR A OG1 1 
ATOM   432  C CG2 . THR A 1 66  ? 5.473   -38.017 1.077   1.00 85.76  ? 78  THR A CG2 1 
ATOM   433  N N   . ASN A 1 67  ? 5.445   -39.790 -1.430  1.00 89.66  ? 79  ASN A N   1 
ATOM   434  C CA  . ASN A 1 67  ? 5.021   -39.426 -2.762  1.00 88.02  ? 79  ASN A CA  1 
ATOM   435  C C   . ASN A 1 67  ? 4.603   -37.968 -2.796  1.00 87.68  ? 79  ASN A C   1 
ATOM   436  O O   . ASN A 1 67  ? 4.644   -37.255 -1.788  1.00 78.43  ? 79  ASN A O   1 
ATOM   437  C CB  . ASN A 1 67  ? 3.896   -40.358 -3.216  1.00 88.60  ? 79  ASN A CB  1 
ATOM   438  C CG  . ASN A 1 67  ? 2.541   -40.082 -2.525  1.00 81.36  ? 79  ASN A CG  1 
ATOM   439  O OD1 . ASN A 1 67  ? 2.315   -39.057 -1.898  1.00 83.23  ? 79  ASN A OD1 1 
ATOM   440  N ND2 . ASN A 1 67  ? 1.641   -41.022 -2.661  1.00 75.94  ? 79  ASN A ND2 1 
ATOM   441  N N   . THR A 1 68  ? 4.147   -37.541 -3.971  1.00 87.42  ? 80  THR A N   1 
ATOM   442  C CA  . THR A 1 68  ? 3.841   -36.135 -4.166  1.00 82.94  ? 80  THR A CA  1 
ATOM   443  C C   . THR A 1 68  ? 2.664   -35.713 -3.299  1.00 84.40  ? 80  THR A C   1 
ATOM   444  O O   . THR A 1 68  ? 2.707   -34.649 -2.670  1.00 90.53  ? 80  THR A O   1 
ATOM   445  C CB  . THR A 1 68  ? 3.584   -35.854 -5.645  1.00 80.41  ? 80  THR A CB  1 
ATOM   446  O OG1 . THR A 1 68  ? 4.789   -36.043 -6.393  1.00 76.54  ? 80  THR A OG1 1 
ATOM   447  C CG2 . THR A 1 68  ? 3.182   -34.436 -5.850  1.00 81.19  ? 80  THR A CG2 1 
ATOM   448  N N   . GLN A 1 69  ? 1.616   -36.544 -3.210  1.00 89.57  ? 81  GLN A N   1 
ATOM   449  C CA  . GLN A 1 69  ? 0.435   -36.202 -2.395  1.00 95.84  ? 81  GLN A CA  1 
ATOM   450  C C   . GLN A 1 69  ? 0.694   -36.323 -0.915  1.00 91.18  ? 81  GLN A C   1 
ATOM   451  O O   . GLN A 1 69  ? -0.250  -36.289 -0.124  1.00 87.08  ? 81  GLN A O   1 
ATOM   452  C CB  . GLN A 1 69  ? -0.768  -37.083 -2.759  1.00 93.20  ? 81  GLN A CB  1 
ATOM   453  C CG  . GLN A 1 69  ? -1.376  -36.779 -4.103  1.00 89.03  ? 81  GLN A CG  1 
ATOM   454  C CD  . GLN A 1 69  ? -0.411  -36.978 -5.244  1.00 86.36  ? 81  GLN A CD  1 
ATOM   455  O OE1 . GLN A 1 69  ? -0.072  -38.101 -5.601  1.00 83.55  ? 81  GLN A OE1 1 
ATOM   456  N NE2 . GLN A 1 69  ? 0.033   -35.876 -5.836  1.00 91.18  ? 81  GLN A NE2 1 
ATOM   457  N N   . LYS A 1 70  ? 1.959   -36.454 -0.550  1.00 91.21  ? 82  LYS A N   1 
ATOM   458  C CA  . LYS A 1 70  ? 2.375   -36.555 0.832   1.00 89.83  ? 82  LYS A CA  1 
ATOM   459  C C   . LYS A 1 70  ? 1.733   -37.794 1.442   1.00 92.58  ? 82  LYS A C   1 
ATOM   460  O O   . LYS A 1 70  ? 0.903   -37.722 2.345   1.00 98.20  ? 82  LYS A O   1 
ATOM   461  C CB  . LYS A 1 70  ? 2.032   -35.256 1.578   1.00 86.95  ? 82  LYS A CB  1 
ATOM   462  C CG  . LYS A 1 70  ? 2.845   -34.093 0.993   1.00 95.33  ? 82  LYS A CG  1 
ATOM   463  C CD  . LYS A 1 70  ? 2.604   -32.702 1.548   1.00 102.15 ? 82  LYS A CD  1 
ATOM   464  C CE  . LYS A 1 70  ? 3.624   -31.737 0.900   1.00 109.57 ? 82  LYS A CE  1 
ATOM   465  N NZ  . LYS A 1 70  ? 3.168   -30.318 0.757   1.00 111.00 ? 82  LYS A NZ  1 
ATOM   466  N N   . GLU A 1 71  ? 2.080   -38.939 0.859   1.00 88.87  ? 83  GLU A N   1 
ATOM   467  C CA  . GLU A 1 71  ? 1.525   -40.208 1.285   1.00 87.67  ? 83  GLU A CA  1 
ATOM   468  C C   . GLU A 1 71  ? 2.638   -41.214 1.493   1.00 86.91  ? 83  GLU A C   1 
ATOM   469  O O   . GLU A 1 71  ? 3.661   -41.200 0.800   1.00 81.90  ? 83  GLU A O   1 
ATOM   470  C CB  . GLU A 1 71  ? 0.526   -40.794 0.279   1.00 91.94  ? 83  GLU A CB  1 
ATOM   471  C CG  . GLU A 1 71  ? -0.694  -39.950 -0.016  1.00 96.29  ? 83  GLU A CG  1 
ATOM   472  C CD  . GLU A 1 71  ? -1.438  -40.446 -1.248  1.00 96.16  ? 83  GLU A CD  1 
ATOM   473  O OE1 . GLU A 1 71  ? -1.077  -41.520 -1.775  1.00 91.54  ? 83  GLU A OE1 1 
ATOM   474  O OE2 . GLU A 1 71  ? -2.358  -39.740 -1.715  1.00 103.63 ? 83  GLU A OE2 1 
ATOM   475  N N   . ALA A 1 72  ? 2.394   -42.108 2.444   1.00 86.92  ? 84  ALA A N   1 
ATOM   476  C CA  . ALA A 1 72  ? 3.376   -43.096 2.850   1.00 89.42  ? 84  ALA A CA  1 
ATOM   477  C C   . ALA A 1 72  ? 3.510   -44.161 1.782   1.00 81.51  ? 84  ALA A C   1 
ATOM   478  O O   . ALA A 1 72  ? 2.567   -44.914 1.542   1.00 85.23  ? 84  ALA A O   1 
ATOM   479  C CB  . ALA A 1 72  ? 2.951   -43.718 4.175   1.00 87.72  ? 84  ALA A CB  1 
ATOM   480  N N   . GLN A 1 73  ? 4.674   -44.244 1.153   1.00 73.66  ? 85  GLN A N   1 
ATOM   481  C CA  . GLN A 1 73  ? 4.891   -45.276 0.159   1.00 78.35  ? 85  GLN A CA  1 
ATOM   482  C C   . GLN A 1 73  ? 6.267   -45.897 0.356   1.00 83.30  ? 85  GLN A C   1 
ATOM   483  O O   . GLN A 1 73  ? 7.190   -45.247 0.844   1.00 86.81  ? 85  GLN A O   1 
ATOM   484  C CB  . GLN A 1 73  ? 4.702   -44.704 -1.263  1.00 88.54  ? 85  GLN A CB  1 
ATOM   485  C CG  . GLN A 1 73  ? 5.929   -44.079 -1.945  1.00 90.68  ? 85  GLN A CG  1 
ATOM   486  C CD  . GLN A 1 73  ? 5.600   -43.442 -3.302  1.00 85.58  ? 85  GLN A CD  1 
ATOM   487  O OE1 . GLN A 1 73  ? 4.457   -43.494 -3.755  1.00 92.75  ? 85  GLN A OE1 1 
ATOM   488  N NE2 . GLN A 1 73  ? 6.601   -42.865 -3.957  1.00 79.81  ? 85  GLN A NE2 1 
ATOM   489  N N   . ALA A 1 74  ? 6.384   -47.177 0.010   1.00 81.42  ? 86  ALA A N   1 
ATOM   490  C CA  . ALA A 1 74  ? 7.656   -47.879 0.047   1.00 75.24  ? 86  ALA A CA  1 
ATOM   491  C C   . ALA A 1 74  ? 8.468   -47.548 -1.191  1.00 73.47  ? 86  ALA A C   1 
ATOM   492  O O   . ALA A 1 74  ? 7.927   -47.114 -2.199  1.00 78.60  ? 86  ALA A O   1 
ATOM   493  C CB  . ALA A 1 74  ? 7.443   -49.388 0.109   1.00 81.70  ? 86  ALA A CB  1 
ATOM   494  N N   . ASN A 1 75  ? 9.778   -47.778 -1.118  1.00 79.25  ? 87  ASN A N   1 
ATOM   495  C CA  . ASN A 1 75  ? 10.619  -47.644 -2.299  1.00 75.61  ? 87  ASN A CA  1 
ATOM   496  C C   . ASN A 1 75  ? 11.955  -48.354 -2.097  1.00 72.98  ? 87  ASN A C   1 
ATOM   497  O O   . ASN A 1 75  ? 12.396  -48.591 -0.975  1.00 74.93  ? 87  ASN A O   1 
ATOM   498  C CB  . ASN A 1 75  ? 10.837  -46.168 -2.658  1.00 81.12  ? 87  ASN A CB  1 
ATOM   499  C CG  . ASN A 1 75  ? 11.415  -45.986 -4.068  1.00 89.42  ? 87  ASN A CG  1 
ATOM   500  O OD1 . ASN A 1 75  ? 11.056  -46.726 -4.987  1.00 95.64  ? 87  ASN A OD1 1 
ATOM   501  N ND2 . ASN A 1 75  ? 12.308  -45.009 -4.242  1.00 84.15  ? 87  ASN A ND2 1 
ATOM   502  N N   . VAL A 1 76  ? 12.604  -48.652 -3.216  1.00 76.01  ? 88  VAL A N   1 
ATOM   503  C CA  . VAL A 1 76  ? 13.850  -49.411 -3.285  1.00 82.44  ? 88  VAL A CA  1 
ATOM   504  C C   . VAL A 1 76  ? 14.991  -48.478 -3.675  1.00 86.55  ? 88  VAL A C   1 
ATOM   505  O O   . VAL A 1 76  ? 14.792  -47.498 -4.410  1.00 80.59  ? 88  VAL A O   1 
ATOM   506  C CB  . VAL A 1 76  ? 13.715  -50.606 -4.271  1.00 80.07  ? 88  VAL A CB  1 
ATOM   507  C CG1 . VAL A 1 76  ? 15.035  -51.051 -4.861  1.00 80.21  ? 88  VAL A CG1 1 
ATOM   508  C CG2 . VAL A 1 76  ? 13.108  -51.802 -3.564  1.00 79.46  ? 88  VAL A CG2 1 
ATOM   509  N N   . ALA A 1 77  ? 16.185  -48.784 -3.163  1.00 83.38  ? 89  ALA A N   1 
ATOM   510  C CA  . ALA A 1 77  ? 17.416  -48.194 -3.647  1.00 83.57  ? 89  ALA A CA  1 
ATOM   511  C C   . ALA A 1 77  ? 18.462  -49.287 -3.747  1.00 83.68  ? 89  ALA A C   1 
ATOM   512  O O   . ALA A 1 77  ? 18.373  -50.309 -3.070  1.00 82.21  ? 89  ALA A O   1 
ATOM   513  C CB  . ALA A 1 77  ? 17.901  -47.064 -2.734  1.00 82.86  ? 89  ALA A CB  1 
ATOM   514  N N   . THR A 1 78  ? 19.444  -49.057 -4.621  1.00 88.70  ? 90  THR A N   1 
ATOM   515  C CA  . THR A 1 78  ? 20.642  -49.885 -4.745  1.00 93.57  ? 90  THR A CA  1 
ATOM   516  C C   . THR A 1 78  ? 21.828  -49.176 -4.089  1.00 94.12  ? 90  THR A C   1 
ATOM   517  O O   . THR A 1 78  ? 22.229  -48.094 -4.534  1.00 91.96  ? 90  THR A O   1 
ATOM   518  C CB  . THR A 1 78  ? 20.966  -50.165 -6.216  1.00 94.70  ? 90  THR A CB  1 
ATOM   519  O OG1 . THR A 1 78  ? 19.836  -50.762 -6.860  1.00 93.70  ? 90  THR A OG1 1 
ATOM   520  C CG2 . THR A 1 78  ? 22.189  -51.085 -6.345  1.00 93.41  ? 90  THR A CG2 1 
ATOM   521  N N   . VAL A 1 79  ? 22.400  -49.790 -3.049  1.00 93.50  ? 91  VAL A N   1 
ATOM   522  C CA  . VAL A 1 79  ? 23.584  -49.257 -2.379  1.00 90.70  ? 91  VAL A CA  1 
ATOM   523  C C   . VAL A 1 79  ? 24.781  -50.158 -2.650  1.00 88.05  ? 91  VAL A C   1 
ATOM   524  O O   . VAL A 1 79  ? 24.657  -51.364 -2.866  1.00 95.46  ? 91  VAL A O   1 
ATOM   525  C CB  . VAL A 1 79  ? 23.382  -49.075 -0.856  1.00 89.18  ? 91  VAL A CB  1 
ATOM   526  C CG1 . VAL A 1 79  ? 22.334  -48.043 -0.586  1.00 91.96  ? 91  VAL A CG1 1 
ATOM   527  C CG2 . VAL A 1 79  ? 22.982  -50.354 -0.204  1.00 89.35  ? 91  VAL A CG2 1 
ATOM   528  N N   . PHE A 1 80  ? 25.949  -49.545 -2.653  1.00 87.29  ? 92  PHE A N   1 
ATOM   529  C CA  . PHE A 1 80  ? 27.234  -50.208 -2.783  1.00 88.32  ? 92  PHE A CA  1 
ATOM   530  C C   . PHE A 1 80  ? 28.054  -49.871 -1.539  1.00 96.35  ? 92  PHE A C   1 
ATOM   531  O O   . PHE A 1 80  ? 27.871  -48.816 -0.924  1.00 99.26  ? 92  PHE A O   1 
ATOM   532  C CB  . PHE A 1 80  ? 27.970  -49.736 -4.053  1.00 86.89  ? 92  PHE A CB  1 
ATOM   533  C CG  . PHE A 1 80  ? 27.213  -49.977 -5.352  1.00 97.07  ? 92  PHE A CG  1 
ATOM   534  C CD1 . PHE A 1 80  ? 26.067  -49.243 -5.662  1.00 97.43  ? 92  PHE A CD1 1 
ATOM   535  C CD2 . PHE A 1 80  ? 27.741  -50.806 -6.341  1.00 106.12 ? 92  PHE A CD2 1 
ATOM   536  C CE1 . PHE A 1 80  ? 25.394  -49.424 -6.871  1.00 91.51  ? 92  PHE A CE1 1 
ATOM   537  C CE2 . PHE A 1 80  ? 27.082  -50.978 -7.573  1.00 104.16 ? 92  PHE A CE2 1 
ATOM   538  C CZ  . PHE A 1 80  ? 25.908  -50.280 -7.830  1.00 97.35  ? 92  PHE A CZ  1 
ATOM   539  N N   . ILE A 1 81  ? 28.941  -50.777 -1.148  1.00 94.20  ? 93  ILE A N   1 
ATOM   540  C CA  . ILE A 1 81  ? 29.860  -50.515 -0.045  1.00 89.72  ? 93  ILE A CA  1 
ATOM   541  C C   . ILE A 1 81  ? 31.275  -50.770 -0.539  1.00 97.41  ? 93  ILE A C   1 
ATOM   542  O O   . ILE A 1 81  ? 31.649  -51.937 -0.741  1.00 106.08 ? 93  ILE A O   1 
ATOM   543  C CB  . ILE A 1 81  ? 29.545  -51.381 1.182   1.00 92.84  ? 93  ILE A CB  1 
ATOM   544  C CG1 . ILE A 1 81  ? 28.152  -51.066 1.726   1.00 92.23  ? 93  ILE A CG1 1 
ATOM   545  C CG2 . ILE A 1 81  ? 30.632  -51.216 2.236   1.00 98.87  ? 93  ILE A CG2 1 
ATOM   546  C CD1 . ILE A 1 81  ? 27.077  -51.961 1.213   1.00 93.96  ? 93  ILE A CD1 1 
ATOM   547  N N   . PRO A 1 82  ? 32.092  -49.732 -0.742  1.00 101.78 ? 94  PRO A N   1 
ATOM   548  C CA  . PRO A 1 82  ? 33.432  -49.957 -1.300  1.00 102.69 ? 94  PRO A CA  1 
ATOM   549  C C   . PRO A 1 82  ? 34.229  -50.907 -0.415  1.00 107.13 ? 94  PRO A C   1 
ATOM   550  O O   . PRO A 1 82  ? 33.953  -51.065 0.780   1.00 107.90 ? 94  PRO A O   1 
ATOM   551  C CB  . PRO A 1 82  ? 34.043  -48.548 -1.345  1.00 94.55  ? 94  PRO A CB  1 
ATOM   552  C CG  . PRO A 1 82  ? 33.291  -47.780 -0.295  1.00 94.66  ? 94  PRO A CG  1 
ATOM   553  C CD  . PRO A 1 82  ? 31.906  -48.348 -0.263  1.00 97.42  ? 94  PRO A CD  1 
ATOM   554  N N   . SER A 1 83  ? 35.182  -51.607 -1.030  1.00 110.57 ? 95  SER A N   1 
ATOM   555  C CA  . SER A 1 83  ? 35.959  -52.569 -0.257  1.00 114.28 ? 95  SER A CA  1 
ATOM   556  C C   . SER A 1 83  ? 36.639  -51.887 0.926   1.00 113.20 ? 95  SER A C   1 
ATOM   557  O O   . SER A 1 83  ? 36.650  -52.437 2.032   1.00 114.89 ? 95  SER A O   1 
ATOM   558  C CB  . SER A 1 83  ? 36.972  -53.288 -1.154  1.00 110.69 ? 95  SER A CB  1 
ATOM   559  O OG  . SER A 1 83  ? 37.876  -52.381 -1.760  1.00 97.53  ? 95  SER A OG  1 
ATOM   560  N N   . LYS A 1 84  ? 37.154  -50.668 0.730   1.00 111.27 ? 96  LYS A N   1 
ATOM   561  C CA  . LYS A 1 84  ? 37.844  -49.908 1.781   1.00 114.64 ? 96  LYS A CA  1 
ATOM   562  C C   . LYS A 1 84  ? 37.376  -48.446 1.861   1.00 108.61 ? 96  LYS A C   1 
ATOM   563  O O   . LYS A 1 84  ? 37.870  -47.574 1.119   1.00 102.09 ? 96  LYS A O   1 
ATOM   564  C CB  . LYS A 1 84  ? 39.367  -50.004 1.599   1.00 119.30 ? 96  LYS A CB  1 
ATOM   565  C CG  . LYS A 1 84  ? 39.961  -49.410 0.307   1.00 121.79 ? 96  LYS A CG  1 
ATOM   566  C CD  . LYS A 1 84  ? 41.481  -49.561 0.221   1.00 122.37 ? 96  LYS A CD  1 
ATOM   567  C CE  . LYS A 1 84  ? 42.059  -48.606 -0.828  1.00 131.47 ? 96  LYS A CE  1 
ATOM   568  N NZ  . LYS A 1 84  ? 43.379  -49.037 -1.370  1.00 128.33 ? 96  LYS A NZ  1 
ATOM   569  N N   . PRO A 1 85  ? 36.466  -48.125 2.783   1.00 102.59 ? 97  PRO A N   1 
ATOM   570  C CA  . PRO A 1 85  ? 35.867  -46.782 2.798   1.00 104.53 ? 97  PRO A CA  1 
ATOM   571  C C   . PRO A 1 85  ? 36.865  -45.672 3.090   1.00 100.80 ? 97  PRO A C   1 
ATOM   572  O O   . PRO A 1 85  ? 37.882  -45.862 3.763   1.00 102.34 ? 97  PRO A O   1 
ATOM   573  C CB  . PRO A 1 85  ? 34.822  -46.867 3.917   1.00 101.77 ? 97  PRO A CB  1 
ATOM   574  C CG  . PRO A 1 85  ? 34.579  -48.323 4.117   1.00 99.14  ? 97  PRO A CG  1 
ATOM   575  C CD  . PRO A 1 85  ? 35.856  -49.016 3.782   1.00 99.76  ? 97  PRO A CD  1 
ATOM   576  N N   . ALA A 1 86  ? 36.546  -44.488 2.580   1.00 97.29  ? 98  ALA A N   1 
ATOM   577  C CA  . ALA A 1 86  ? 37.287  -43.311 2.975   1.00 92.98  ? 98  ALA A CA  1 
ATOM   578  C C   . ALA A 1 86  ? 37.016  -43.005 4.442   1.00 96.27  ? 98  ALA A C   1 
ATOM   579  O O   . ALA A 1 86  ? 35.967  -43.358 5.000   1.00 92.78  ? 98  ALA A O   1 
ATOM   580  C CB  . ALA A 1 86  ? 36.917  -42.119 2.098   1.00 83.27  ? 98  ALA A CB  1 
ATOM   581  N N   . SER A 1 87  ? 38.016  -42.399 5.074   1.00 99.10  ? 99  SER A N   1 
ATOM   582  C CA  . SER A 1 87  ? 37.929  -41.809 6.402   1.00 95.37  ? 99  SER A CA  1 
ATOM   583  C C   . SER A 1 87  ? 38.271  -40.330 6.295   1.00 101.00 ? 99  SER A C   1 
ATOM   584  O O   . SER A 1 87  ? 39.392  -39.993 5.875   1.00 103.27 ? 99  SER A O   1 
ATOM   585  C CB  . SER A 1 87  ? 38.880  -42.492 7.373   1.00 99.11  ? 99  SER A CB  1 
ATOM   586  O OG  . SER A 1 87  ? 38.740  -41.933 8.661   1.00 98.33  ? 99  SER A OG  1 
ATOM   587  N N   . PRO A 1 88  ? 37.311  -39.413 6.580   1.00 102.78 ? 100 PRO A N   1 
ATOM   588  C CA  . PRO A 1 88  ? 36.032  -39.796 7.162   1.00 97.87  ? 100 PRO A CA  1 
ATOM   589  C C   . PRO A 1 88  ? 35.073  -40.337 6.113   1.00 98.65  ? 100 PRO A C   1 
ATOM   590  O O   . PRO A 1 88  ? 35.301  -40.140 4.902   1.00 95.97  ? 100 PRO A O   1 
ATOM   591  C CB  . PRO A 1 88  ? 35.557  -38.469 7.766   1.00 87.33  ? 100 PRO A CB  1 
ATOM   592  C CG  . PRO A 1 88  ? 36.028  -37.441 6.772   1.00 95.87  ? 100 PRO A CG  1 
ATOM   593  C CD  . PRO A 1 88  ? 37.388  -37.962 6.345   1.00 96.53  ? 100 PRO A CD  1 
ATOM   594  N N   . PRO A 1 89  ? 33.989  -41.034 6.512   1.00 96.93  ? 101 PRO A N   1 
ATOM   595  C CA  . PRO A 1 89  ? 33.095  -41.641 5.541   1.00 98.46  ? 101 PRO A CA  1 
ATOM   596  C C   . PRO A 1 89  ? 32.416  -40.585 4.694   1.00 104.83 ? 101 PRO A C   1 
ATOM   597  O O   . PRO A 1 89  ? 32.110  -39.498 5.217   1.00 98.80  ? 101 PRO A O   1 
ATOM   598  C CB  . PRO A 1 89  ? 32.103  -42.407 6.424   1.00 98.08  ? 101 PRO A CB  1 
ATOM   599  C CG  . PRO A 1 89  ? 32.150  -41.681 7.745   1.00 90.98  ? 101 PRO A CG  1 
ATOM   600  C CD  . PRO A 1 89  ? 33.606  -41.284 7.891   1.00 95.96  ? 101 PRO A CD  1 
ATOM   601  N N   . LYS A 1 90  ? 32.234  -40.872 3.402   1.00 104.11 ? 102 LYS A N   1 
ATOM   602  C CA  . LYS A 1 90  ? 31.529  -39.934 2.492   1.00 91.94  ? 102 LYS A CA  1 
ATOM   603  C C   . LYS A 1 90  ? 30.485  -40.726 1.691   1.00 88.63  ? 102 LYS A C   1 
ATOM   604  O O   . LYS A 1 90  ? 30.742  -41.911 1.397   1.00 90.86  ? 102 LYS A O   1 
ATOM   605  C CB  . LYS A 1 90  ? 32.526  -39.246 1.556   1.00 90.24  ? 102 LYS A CB  1 
ATOM   606  C CG  . LYS A 1 90  ? 33.370  -38.160 2.204   1.00 93.45  ? 102 LYS A CG  1 
ATOM   607  C CD  . LYS A 1 90  ? 32.523  -37.150 2.967   1.00 89.69  ? 102 LYS A CD  1 
ATOM   608  C CE  . LYS A 1 90  ? 33.283  -36.453 4.045   1.00 89.01  ? 102 LYS A CE  1 
ATOM   609  N NZ  . LYS A 1 90  ? 32.516  -35.330 4.589   1.00 94.48  ? 102 LYS A NZ  1 
ATOM   610  N N   . ILE A 1 91  ? 29.367  -40.090 1.336   1.00 85.11  ? 103 ILE A N   1 
ATOM   611  C CA  . ILE A 1 91  ? 28.280  -40.797 0.595   1.00 84.39  ? 103 ILE A CA  1 
ATOM   612  C C   . ILE A 1 91  ? 28.195  -40.191 -0.811  1.00 82.06  ? 103 ILE A C   1 
ATOM   613  O O   . ILE A 1 91  ? 28.200  -38.949 -0.924  1.00 84.68  ? 103 ILE A O   1 
ATOM   614  C CB  . ILE A 1 91  ? 26.929  -40.708 1.328   1.00 81.89  ? 103 ILE A CB  1 
ATOM   615  C CG1 . ILE A 1 91  ? 26.734  -41.857 2.304   1.00 82.32  ? 103 ILE A CG1 1 
ATOM   616  C CG2 . ILE A 1 91  ? 25.764  -40.642 0.339   1.00 78.84  ? 103 ILE A CG2 1 
ATOM   617  C CD1 . ILE A 1 91  ? 25.285  -42.063 2.710   1.00 83.13  ? 103 ILE A CD1 1 
ATOM   618  N N   . PHE A 1 92  ? 28.163  -41.040 -1.837  1.00 76.47  ? 104 PHE A N   1 
ATOM   619  C CA  . PHE A 1 92  ? 28.005  -40.534 -3.222  1.00 77.41  ? 104 PHE A CA  1 
ATOM   620  C C   . PHE A 1 92  ? 26.630  -40.947 -3.698  1.00 86.65  ? 104 PHE A C   1 
ATOM   621  O O   . PHE A 1 92  ? 26.283  -42.141 -3.604  1.00 89.13  ? 104 PHE A O   1 
ATOM   622  C CB  . PHE A 1 92  ? 29.095  -41.137 -4.110  1.00 83.50  ? 104 PHE A CB  1 
ATOM   623  C CG  . PHE A 1 92  ? 29.107  -40.654 -5.554  1.00 88.26  ? 104 PHE A CG  1 
ATOM   624  C CD1 . PHE A 1 92  ? 28.214  -41.166 -6.490  1.00 85.72  ? 104 PHE A CD1 1 
ATOM   625  C CD2 . PHE A 1 92  ? 30.028  -39.704 -5.977  1.00 93.24  ? 104 PHE A CD2 1 
ATOM   626  C CE1 . PHE A 1 92  ? 28.233  -40.725 -7.803  1.00 89.16  ? 104 PHE A CE1 1 
ATOM   627  C CE2 . PHE A 1 92  ? 30.047  -39.275 -7.293  1.00 82.39  ? 104 PHE A CE2 1 
ATOM   628  C CZ  . PHE A 1 92  ? 29.149  -39.782 -8.201  1.00 83.88  ? 104 PHE A CZ  1 
ATOM   629  N N   . SER A 1 93  ? 25.859  -39.985 -4.205  1.00 89.78  ? 105 SER A N   1 
ATOM   630  C CA  . SER A 1 93  ? 24.524  -40.319 -4.756  1.00 82.31  ? 105 SER A CA  1 
ATOM   631  C C   . SER A 1 93  ? 24.552  -40.097 -6.270  1.00 84.09  ? 105 SER A C   1 
ATOM   632  O O   . SER A 1 93  ? 24.941  -38.993 -6.700  1.00 83.70  ? 105 SER A O   1 
ATOM   633  C CB  . SER A 1 93  ? 23.440  -39.508 -4.104  1.00 72.17  ? 105 SER A CB  1 
ATOM   634  O OG  . SER A 1 93  ? 22.161  -40.065 -4.376  1.00 70.33  ? 105 SER A OG  1 
ATOM   635  N N   . TYR A 1 94  ? 24.153  -41.111 -7.035  1.00 84.08  ? 106 TYR A N   1 
ATOM   636  C CA  . TYR A 1 94  ? 24.121  -40.994 -8.515  1.00 78.28  ? 106 TYR A CA  1 
ATOM   637  C C   . TYR A 1 94  ? 22.674  -41.153 -8.929  1.00 85.19  ? 106 TYR A C   1 
ATOM   638  O O   . TYR A 1 94  ? 22.021  -42.100 -8.450  1.00 87.95  ? 106 TYR A O   1 
ATOM   639  C CB  . TYR A 1 94  ? 25.010  -42.060 -9.156  1.00 77.49  ? 106 TYR A CB  1 
ATOM   640  C CG  . TYR A 1 94  ? 24.935  -42.112 -10.675 1.00 74.03  ? 106 TYR A CG  1 
ATOM   641  C CD1 . TYR A 1 94  ? 24.045  -42.957 -11.325 1.00 70.55  ? 106 TYR A CD1 1 
ATOM   642  C CD2 . TYR A 1 94  ? 25.757  -41.312 -11.457 1.00 78.27  ? 106 TYR A CD2 1 
ATOM   643  C CE1 . TYR A 1 94  ? 23.969  -42.999 -12.706 1.00 74.41  ? 106 TYR A CE1 1 
ATOM   644  C CE2 . TYR A 1 94  ? 25.694  -41.349 -12.839 1.00 80.08  ? 106 TYR A CE2 1 
ATOM   645  C CZ  . TYR A 1 94  ? 24.800  -42.197 -13.466 1.00 80.78  ? 106 TYR A CZ  1 
ATOM   646  O OH  . TYR A 1 94  ? 24.741  -42.235 -14.828 1.00 84.05  ? 106 TYR A OH  1 
ATOM   647  N N   . GLN A 1 95  ? 22.167  -40.260 -9.778  1.00 83.01  ? 107 GLN A N   1 
ATOM   648  C CA  . GLN A 1 95  ? 20.777  -40.479 -10.238 1.00 79.61  ? 107 GLN A CA  1 
ATOM   649  C C   . GLN A 1 95  ? 20.819  -40.936 -11.700 1.00 83.62  ? 107 GLN A C   1 
ATOM   650  O O   . GLN A 1 95  ? 21.371  -40.196 -12.540 1.00 79.78  ? 107 GLN A O   1 
ATOM   651  C CB  . GLN A 1 95  ? 20.006  -39.176 -10.033 1.00 77.35  ? 107 GLN A CB  1 
ATOM   652  C CG  . GLN A 1 95  ? 19.522  -38.952 -8.604  1.00 79.50  ? 107 GLN A CG  1 
ATOM   653  C CD  . GLN A 1 95  ? 20.634  -38.690 -7.610  1.00 78.62  ? 107 GLN A CD  1 
ATOM   654  O OE1 . GLN A 1 95  ? 20.807  -39.422 -6.630  1.00 73.07  ? 107 GLN A OE1 1 
ATOM   655  N NE2 . GLN A 1 95  ? 21.405  -37.642 -7.855  1.00 74.20  ? 107 GLN A NE2 1 
ATOM   656  N N   . VAL A 1 96  ? 20.270  -42.121 -11.975 1.00 91.73  ? 108 VAL A N   1 
ATOM   657  C CA  . VAL A 1 96  ? 20.228  -42.659 -13.367 1.00 87.71  ? 108 VAL A CA  1 
ATOM   658  C C   . VAL A 1 96  ? 19.200  -41.871 -14.190 1.00 82.73  ? 108 VAL A C   1 
ATOM   659  O O   . VAL A 1 96  ? 18.157  -41.494 -13.625 1.00 77.27  ? 108 VAL A O   1 
ATOM   660  C CB  . VAL A 1 96  ? 19.923  -44.168 -13.358 1.00 83.25  ? 108 VAL A CB  1 
ATOM   661  C CG1 . VAL A 1 96  ? 20.125  -44.797 -14.731 1.00 90.65  ? 108 VAL A CG1 1 
ATOM   662  C CG2 . VAL A 1 96  ? 20.763  -44.896 -12.316 1.00 85.48  ? 108 VAL A CG2 1 
ATOM   663  N N   . TYR A 1 97  ? 19.479  -41.641 -15.472 1.00 78.88  ? 109 TYR A N   1 
ATOM   664  C CA  . TYR A 1 97  ? 18.479  -40.984 -16.349 1.00 75.95  ? 109 TYR A CA  1 
ATOM   665  C C   . TYR A 1 97  ? 17.554  -42.069 -16.865 1.00 82.02  ? 109 TYR A C   1 
ATOM   666  O O   . TYR A 1 97  ? 17.587  -42.379 -18.072 1.00 87.05  ? 109 TYR A O   1 
ATOM   667  C CB  . TYR A 1 97  ? 19.294  -40.314 -17.457 1.00 79.84  ? 109 TYR A CB  1 
ATOM   668  C CG  . TYR A 1 97  ? 20.555  -41.084 -17.830 1.00 85.78  ? 109 TYR A CG  1 
ATOM   669  C CD1 . TYR A 1 97  ? 20.504  -42.145 -18.725 1.00 90.64  ? 109 TYR A CD1 1 
ATOM   670  C CD2 . TYR A 1 97  ? 21.791  -40.763 -17.281 1.00 84.81  ? 109 TYR A CD2 1 
ATOM   671  C CE1 . TYR A 1 97  ? 21.636  -42.864 -19.063 1.00 90.71  ? 109 TYR A CE1 1 
ATOM   672  C CE2 . TYR A 1 97  ? 22.931  -41.477 -17.609 1.00 82.40  ? 109 TYR A CE2 1 
ATOM   673  C CZ  . TYR A 1 97  ? 22.853  -42.529 -18.504 1.00 86.18  ? 109 TYR A CZ  1 
ATOM   674  O OH  . TYR A 1 97  ? 23.959  -43.247 -18.848 1.00 97.15  ? 109 TYR A OH  1 
ATOM   675  N N   . GLU A 1 98  ? 16.707  -42.625 -15.997 1.00 84.69  ? 110 GLU A N   1 
ATOM   676  C CA  . GLU A 1 98  ? 15.890  -43.773 -16.462 1.00 83.43  ? 110 GLU A CA  1 
ATOM   677  C C   . GLU A 1 98  ? 14.980  -43.297 -17.598 1.00 85.02  ? 110 GLU A C   1 
ATOM   678  O O   . GLU A 1 98  ? 14.880  -44.023 -18.609 1.00 84.33  ? 110 GLU A O   1 
ATOM   679  C CB  . GLU A 1 98  ? 15.109  -44.314 -15.265 1.00 75.22  ? 110 GLU A CB  1 
ATOM   680  C CG  . GLU A 1 98  ? 13.784  -44.976 -15.629 1.00 85.17  ? 110 GLU A CG  1 
ATOM   681  C CD  . GLU A 1 98  ? 12.984  -45.389 -14.408 1.00 89.50  ? 110 GLU A CD  1 
ATOM   682  O OE1 . GLU A 1 98  ? 13.501  -45.207 -13.287 1.00 83.30  ? 110 GLU A OE1 1 
ATOM   683  O OE2 . GLU A 1 98  ? 11.852  -45.889 -14.568 1.00 91.02  ? 110 GLU A OE2 1 
ATOM   684  N N   . ASP A 1 99  ? 14.360  -42.125 -17.448 1.00 82.12  ? 111 ASP A N   1 
ATOM   685  C CA  . ASP A 1 99  ? 13.549  -41.530 -18.548 1.00 84.17  ? 111 ASP A CA  1 
ATOM   686  C C   . ASP A 1 99  ? 12.483  -42.535 -19.002 1.00 82.31  ? 111 ASP A C   1 
ATOM   687  O O   . ASP A 1 99  ? 12.228  -42.606 -20.222 1.00 75.89  ? 111 ASP A O   1 
ATOM   688  C CB  . ASP A 1 99  ? 14.439  -41.022 -19.671 1.00 79.70  ? 111 ASP A CB  1 
ATOM   689  C CG  . ASP A 1 99  ? 15.548  -40.076 -19.237 1.00 84.58  ? 111 ASP A CG  1 
ATOM   690  O OD1 . ASP A 1 99  ? 15.544  -39.674 -18.056 1.00 86.67  ? 111 ASP A OD1 1 
ATOM   691  O OD2 . ASP A 1 99  ? 16.407  -39.752 -20.082 1.00 85.98  ? 111 ASP A OD2 1 
ATOM   692  N N   . SER A 1 100 ? 11.899  -43.290 -18.068 1.00 77.91  ? 112 SER A N   1 
ATOM   693  C CA  . SER A 1 100 ? 10.887  -44.317 -18.432 1.00 77.19  ? 112 SER A CA  1 
ATOM   694  C C   . SER A 1 100 ? 9.785   -44.382 -17.368 1.00 82.83  ? 112 SER A C   1 
ATOM   695  O O   . SER A 1 100 ? 10.078  -44.059 -16.206 1.00 83.58  ? 112 SER A O   1 
ATOM   696  C CB  . SER A 1 100 ? 11.525  -45.653 -18.642 1.00 74.29  ? 112 SER A CB  1 
ATOM   697  O OG  . SER A 1 100 ? 12.871  -45.540 -19.081 1.00 75.52  ? 112 SER A OG  1 
ATOM   698  N N   . THR A 1 101 ? 8.573   -44.789 -17.751 1.00 80.26  ? 113 THR A N   1 
ATOM   699  C CA  . THR A 1 101 ? 7.436   -44.805 -16.798 1.00 82.23  ? 113 THR A CA  1 
ATOM   700  C C   . THR A 1 101 ? 7.116   -46.198 -16.265 1.00 85.31  ? 113 THR A C   1 
ATOM   701  O O   . THR A 1 101 ? 6.059   -46.328 -15.611 1.00 86.15  ? 113 THR A O   1 
ATOM   702  C CB  . THR A 1 101 ? 6.237   -44.101 -17.428 1.00 79.84  ? 113 THR A CB  1 
ATOM   703  O OG1 . THR A 1 101 ? 6.250   -44.445 -18.808 1.00 80.75  ? 113 THR A OG1 1 
ATOM   704  C CG2 . THR A 1 101 ? 6.361   -42.596 -17.287 1.00 78.43  ? 113 THR A CG2 1 
ATOM   705  N N   . GLN A 1 102 ? 7.936   -47.215 -16.551 1.00 84.10  ? 114 GLN A N   1 
ATOM   706  C CA  . GLN A 1 102 ? 7.594   -48.604 -16.128 1.00 86.50  ? 114 GLN A CA  1 
ATOM   707  C C   . GLN A 1 102 ? 8.547   -49.090 -15.015 1.00 91.14  ? 114 GLN A C   1 
ATOM   708  O O   . GLN A 1 102 ? 9.678   -48.574 -14.944 1.00 92.64  ? 114 GLN A O   1 
ATOM   709  C CB  . GLN A 1 102 ? 7.575   -49.472 -17.387 1.00 91.65  ? 114 GLN A CB  1 
ATOM   710  C CG  . GLN A 1 102 ? 7.383   -50.964 -17.143 1.00 94.19  ? 114 GLN A CG  1 
ATOM   711  C CD  . GLN A 1 102 ? 6.150   -51.312 -16.340 1.00 98.08  ? 114 GLN A CD  1 
ATOM   712  O OE1 . GLN A 1 102 ? 6.236   -51.806 -15.211 1.00 96.26  ? 114 GLN A OE1 1 
ATOM   713  N NE2 . GLN A 1 102 ? 4.985   -51.072 -16.922 1.00 95.31  ? 114 GLN A NE2 1 
ATOM   714  N N   . LEU A 1 103 ? 8.106   -50.040 -14.178 1.00 90.49  ? 115 LEU A N   1 
ATOM   715  C CA  . LEU A 1 103 ? 8.917   -50.556 -13.036 1.00 90.72  ? 115 LEU A CA  1 
ATOM   716  C C   . LEU A 1 103 ? 10.195  -51.281 -13.502 1.00 95.04  ? 115 LEU A C   1 
ATOM   717  O O   . LEU A 1 103 ? 11.232  -51.114 -12.839 1.00 94.23  ? 115 LEU A O   1 
ATOM   718  C CB  . LEU A 1 103 ? 8.048   -51.465 -12.169 1.00 89.47  ? 115 LEU A CB  1 
ATOM   719  C CG  . LEU A 1 103 ? 8.193   -51.276 -10.657 1.00 83.99  ? 115 LEU A CG  1 
ATOM   720  C CD1 . LEU A 1 103 ? 8.191   -49.801 -10.298 1.00 93.53  ? 115 LEU A CD1 1 
ATOM   721  C CD2 . LEU A 1 103 ? 7.102   -52.014 -9.904  1.00 97.43  ? 115 LEU A CD2 1 
ATOM   722  N N   . ASN A 1 104 ? 10.133  -52.056 -14.584 1.00 96.19  ? 116 ASN A N   1 
ATOM   723  C CA  . ASN A 1 104 ? 11.319  -52.830 -15.055 1.00 96.45  ? 116 ASN A CA  1 
ATOM   724  C C   . ASN A 1 104 ? 12.394  -51.793 -15.389 1.00 96.89  ? 116 ASN A C   1 
ATOM   725  O O   . ASN A 1 104 ? 13.586  -52.073 -15.149 1.00 103.41 ? 116 ASN A O   1 
ATOM   726  C CB  . ASN A 1 104 ? 10.990  -53.815 -16.172 1.00 94.08  ? 116 ASN A CB  1 
ATOM   727  C CG  . ASN A 1 104 ? 9.829   -53.374 -17.025 1.00 93.53  ? 116 ASN A CG  1 
ATOM   728  O OD1 . ASN A 1 104 ? 10.006  -52.558 -17.935 1.00 96.84  ? 116 ASN A OD1 1 
ATOM   729  N ND2 . ASN A 1 104 ? 8.650   -53.917 -16.761 1.00 92.22  ? 116 ASN A ND2 1 
ATOM   730  N N   . CYS A 1 105 ? 11.972  -50.616 -15.841 1.00 95.18  ? 117 CYS A N   1 
ATOM   731  C CA  . CYS A 1 105 ? 12.937  -49.547 -16.192 1.00 103.81 ? 117 CYS A CA  1 
ATOM   732  C C   . CYS A 1 105 ? 13.644  -49.027 -14.934 1.00 105.68 ? 117 CYS A C   1 
ATOM   733  O O   . CYS A 1 105 ? 14.488  -48.125 -15.069 1.00 97.64  ? 117 CYS A O   1 
ATOM   734  C CB  . CYS A 1 105 ? 12.206  -48.395 -16.857 1.00 95.92  ? 117 CYS A CB  1 
ATOM   735  S SG  . CYS A 1 105 ? 11.048  -48.974 -18.118 1.00 81.01  ? 117 CYS A SG  1 
ATOM   736  N N   . ALA A 1 106 ? 13.369  -49.615 -13.771 1.00 101.85 ? 118 ALA A N   1 
ATOM   737  C CA  . ALA A 1 106 ? 13.954  -49.064 -12.527 1.00 98.78  ? 118 ALA A CA  1 
ATOM   738  C C   . ALA A 1 106 ? 15.473  -49.199 -12.579 1.00 101.94 ? 118 ALA A C   1 
ATOM   739  O O   . ALA A 1 106 ? 15.992  -50.201 -13.116 1.00 104.30 ? 118 ALA A O   1 
ATOM   740  C CB  . ALA A 1 106 ? 13.396  -49.754 -11.304 1.00 92.26  ? 118 ALA A CB  1 
ATOM   741  N N   . PRO A 1 107 ? 16.215  -48.233 -12.004 1.00 101.14 ? 119 PRO A N   1 
ATOM   742  C CA  . PRO A 1 107 ? 17.665  -48.290 -12.006 1.00 105.54 ? 119 PRO A CA  1 
ATOM   743  C C   . PRO A 1 107 ? 18.079  -49.551 -11.272 1.00 98.20  ? 119 PRO A C   1 
ATOM   744  O O   . PRO A 1 107 ? 19.044  -50.198 -11.709 1.00 93.84  ? 119 PRO A O   1 
ATOM   745  C CB  . PRO A 1 107 ? 18.065  -47.016 -11.259 1.00 98.09  ? 119 PRO A CB  1 
ATOM   746  C CG  . PRO A 1 107 ? 16.906  -46.078 -11.495 1.00 90.30  ? 119 PRO A CG  1 
ATOM   747  C CD  . PRO A 1 107 ? 15.692  -46.988 -11.469 1.00 87.84  ? 119 PRO A CD  1 
ATOM   748  N N   . SER A 1 108 ? 17.382  -49.906 -10.191 1.00 89.75  ? 120 SER A N   1 
ATOM   749  C CA  . SER A 1 108 ? 17.824  -51.080 -9.401  1.00 92.94  ? 120 SER A CA  1 
ATOM   750  C C   . SER A 1 108 ? 17.775  -52.339 -10.276 1.00 97.55  ? 120 SER A C   1 
ATOM   751  O O   . SER A 1 108 ? 18.750  -53.118 -10.237 1.00 98.10  ? 120 SER A O   1 
ATOM   752  C CB  . SER A 1 108 ? 16.947  -51.252 -8.198  1.00 86.25  ? 120 SER A CB  1 
ATOM   753  O OG  . SER A 1 108 ? 15.587  -51.388 -8.584  1.00 75.76  ? 120 SER A OG  1 
ATOM   754  N N   . TYR A 1 109 ? 16.720  -52.498 -11.079 1.00 98.88  ? 121 TYR A N   1 
ATOM   755  C CA  . TYR A 1 109 ? 16.634  -53.658 -12.010 1.00 100.93 ? 121 TYR A CA  1 
ATOM   756  C C   . TYR A 1 109 ? 17.773  -53.557 -13.016 1.00 96.61  ? 121 TYR A C   1 
ATOM   757  O O   . TYR A 1 109 ? 18.399  -54.585 -13.336 1.00 98.39  ? 121 TYR A O   1 
ATOM   758  C CB  . TYR A 1 109 ? 15.266  -53.713 -12.695 1.00 112.04 ? 121 TYR A CB  1 
ATOM   759  C CG  . TYR A 1 109 ? 14.811  -55.123 -13.044 1.00 114.80 ? 121 TYR A CG  1 
ATOM   760  C CD1 . TYR A 1 109 ? 14.971  -56.167 -12.143 1.00 120.15 ? 121 TYR A CD1 1 
ATOM   761  C CD2 . TYR A 1 109 ? 14.228  -55.411 -14.272 1.00 110.92 ? 121 TYR A CD2 1 
ATOM   762  C CE1 . TYR A 1 109 ? 14.567  -57.456 -12.448 1.00 123.11 ? 121 TYR A CE1 1 
ATOM   763  C CE2 . TYR A 1 109 ? 13.818  -56.696 -14.589 1.00 111.46 ? 121 TYR A CE2 1 
ATOM   764  C CZ  . TYR A 1 109 ? 13.989  -57.720 -13.676 1.00 119.22 ? 121 TYR A CZ  1 
ATOM   765  O OH  . TYR A 1 109 ? 13.591  -58.991 -13.975 1.00 117.36 ? 121 TYR A OH  1 
ATOM   766  N N   . SER A 1 110 ? 18.055  -52.339 -13.482 1.00 93.96  ? 122 SER A N   1 
ATOM   767  C CA  . SER A 1 110 ? 19.131  -52.112 -14.481 1.00 94.22  ? 122 SER A CA  1 
ATOM   768  C C   . SER A 1 110 ? 20.480  -52.522 -13.879 1.00 91.52  ? 122 SER A C   1 
ATOM   769  O O   . SER A 1 110 ? 21.305  -53.090 -14.612 1.00 88.88  ? 122 SER A O   1 
ATOM   770  C CB  . SER A 1 110 ? 19.142  -50.683 -14.930 1.00 94.54  ? 122 SER A CB  1 
ATOM   771  O OG  . SER A 1 110 ? 17.832  -50.134 -14.910 1.00 99.47  ? 122 SER A OG  1 
ATOM   772  N N   . TYR A 1 111 ? 20.696  -52.242 -12.592 1.00 91.52  ? 123 TYR A N   1 
ATOM   773  C CA  . TYR A 1 111 ? 22.014  -52.539 -11.968 1.00 94.73  ? 123 TYR A CA  1 
ATOM   774  C C   . TYR A 1 111 ? 22.233  -54.045 -11.937 1.00 101.29 ? 123 TYR A C   1 
ATOM   775  O O   . TYR A 1 111 ? 23.397  -54.489 -11.869 1.00 108.58 ? 123 TYR A O   1 
ATOM   776  C CB  . TYR A 1 111 ? 22.065  -51.936 -10.563 1.00 98.90  ? 123 TYR A CB  1 
ATOM   777  C CG  . TYR A 1 111 ? 22.408  -50.454 -10.558 1.00 95.33  ? 123 TYR A CG  1 
ATOM   778  C CD1 . TYR A 1 111 ? 23.588  -49.993 -11.128 1.00 91.19  ? 123 TYR A CD1 1 
ATOM   779  C CD2 . TYR A 1 111 ? 21.549  -49.520 -9.996  1.00 89.02  ? 123 TYR A CD2 1 
ATOM   780  C CE1 . TYR A 1 111 ? 23.904  -48.645 -11.135 1.00 85.76  ? 123 TYR A CE1 1 
ATOM   781  C CE2 . TYR A 1 111 ? 21.852  -48.170 -10.000 1.00 83.69  ? 123 TYR A CE2 1 
ATOM   782  C CZ  . TYR A 1 111 ? 23.034  -47.732 -10.569 1.00 81.87  ? 123 TYR A CZ  1 
ATOM   783  O OH  . TYR A 1 111 ? 23.340  -46.404 -10.573 1.00 82.07  ? 123 TYR A OH  1 
ATOM   784  N N   . LEU A 1 112 ? 21.148  -54.816 -12.006 1.00 101.81 ? 124 LEU A N   1 
ATOM   785  C CA  . LEU A 1 112 ? 21.250  -56.298 -11.915 1.00 98.84  ? 124 LEU A CA  1 
ATOM   786  C C   . LEU A 1 112 ? 21.935  -56.870 -13.165 1.00 100.69 ? 124 LEU A C   1 
ATOM   787  O O   . LEU A 1 112 ? 21.817  -56.252 -14.242 1.00 95.81  ? 124 LEU A O   1 
ATOM   788  C CB  . LEU A 1 112 ? 19.879  -56.916 -11.659 1.00 95.19  ? 124 LEU A CB  1 
ATOM   789  C CG  . LEU A 1 112 ? 19.207  -56.470 -10.359 1.00 92.33  ? 124 LEU A CG  1 
ATOM   790  C CD1 . LEU A 1 112 ? 17.758  -56.893 -10.349 1.00 98.06  ? 124 LEU A CD1 1 
ATOM   791  C CD2 . LEU A 1 112 ? 19.944  -57.022 -9.154  1.00 90.47  ? 124 LEU A CD2 1 
ATOM   792  N N   . THR A 1 113 ? 22.543  -58.050 -13.049 1.00 102.86 ? 125 THR A N   1 
ATOM   793  C CA  . THR A 1 113 ? 23.333  -58.601 -14.174 1.00 105.57 ? 125 THR A CA  1 
ATOM   794  C C   . THR A 1 113 ? 22.475  -59.180 -15.281 1.00 103.30 ? 125 THR A C   1 
ATOM   795  O O   . THR A 1 113 ? 21.271  -59.390 -15.056 1.00 97.04  ? 125 THR A O   1 
ATOM   796  C CB  . THR A 1 113 ? 24.278  -59.656 -13.606 1.00 104.87 ? 125 THR A CB  1 
ATOM   797  O OG1 . THR A 1 113 ? 23.438  -60.763 -13.299 1.00 113.58 ? 125 THR A OG1 1 
ATOM   798  C CG2 . THR A 1 113 ? 24.991  -59.178 -12.354 1.00 99.80  ? 125 THR A CG2 1 
ATOM   799  N N   . GLY A 1 114 ? 23.085  -59.458 -16.437 1.00 105.33 ? 126 GLY A N   1 
ATOM   800  C CA  . GLY A 1 114 ? 22.397  -60.099 -17.576 1.00 111.51 ? 126 GLY A CA  1 
ATOM   801  C C   . GLY A 1 114 ? 21.879  -59.159 -18.649 1.00 107.44 ? 126 GLY A C   1 
ATOM   802  O O   . GLY A 1 114 ? 21.552  -58.005 -18.317 1.00 104.56 ? 126 GLY A O   1 
ATOM   803  N N   . PHE A 1 115 ? 21.771  -59.654 -19.886 1.00 115.28 ? 127 PHE A N   1 
ATOM   804  C CA  . PHE A 1 115 ? 21.282  -58.883 -21.067 1.00 114.88 ? 127 PHE A CA  1 
ATOM   805  C C   . PHE A 1 115 ? 19.825  -58.464 -20.961 1.00 108.52 ? 127 PHE A C   1 
ATOM   806  O O   . PHE A 1 115 ? 19.498  -57.349 -21.417 1.00 108.33 ? 127 PHE A O   1 
ATOM   807  C CB  . PHE A 1 115 ? 21.472  -59.728 -22.332 1.00 122.04 ? 127 PHE A CB  1 
ATOM   808  C CG  . PHE A 1 115 ? 21.389  -61.237 -22.141 1.00 126.67 ? 127 PHE A CG  1 
ATOM   809  C CD1 . PHE A 1 115 ? 20.176  -61.861 -21.872 1.00 119.08 ? 127 PHE A CD1 1 
ATOM   810  C CD2 . PHE A 1 115 ? 22.524  -62.031 -22.251 1.00 133.59 ? 127 PHE A CD2 1 
ATOM   811  C CE1 . PHE A 1 115 ? 20.107  -63.233 -21.705 1.00 119.64 ? 127 PHE A CE1 1 
ATOM   812  C CE2 . PHE A 1 115 ? 22.447  -63.405 -22.088 1.00 132.83 ? 127 PHE A CE2 1 
ATOM   813  C CZ  . PHE A 1 115 ? 21.240  -64.003 -21.815 1.00 124.67 ? 127 PHE A CZ  1 
ATOM   814  N N   . ASP A 1 116 ? 18.967  -59.305 -20.388 1.00 110.63 ? 128 ASP A N   1 
ATOM   815  C CA  . ASP A 1 116 ? 17.491  -59.103 -20.457 1.00 109.45 ? 128 ASP A CA  1 
ATOM   816  C C   . ASP A 1 116 ? 16.961  -57.804 -19.845 1.00 109.91 ? 128 ASP A C   1 
ATOM   817  O O   . ASP A 1 116 ? 16.010  -57.255 -20.438 1.00 111.41 ? 128 ASP A O   1 
ATOM   818  C CB  . ASP A 1 116 ? 16.757  -60.281 -19.839 1.00 112.13 ? 128 ASP A CB  1 
ATOM   819  C CG  . ASP A 1 116 ? 17.415  -60.901 -18.617 1.00 116.45 ? 128 ASP A CG  1 
ATOM   820  O OD1 . ASP A 1 116 ? 18.470  -60.390 -18.184 1.00 118.03 ? 128 ASP A OD1 1 
ATOM   821  O OD2 . ASP A 1 116 ? 16.857  -61.888 -18.106 1.00 119.33 ? 128 ASP A OD2 1 
ATOM   822  N N   . GLU A 1 117 ? 17.498  -57.314 -18.727 1.00 108.07 ? 129 GLU A N   1 
ATOM   823  C CA  . GLU A 1 117 ? 16.818  -56.141 -18.116 1.00 105.44 ? 129 GLU A CA  1 
ATOM   824  C C   . GLU A 1 117 ? 16.781  -54.984 -19.125 1.00 102.26 ? 129 GLU A C   1 
ATOM   825  O O   . GLU A 1 117 ? 17.816  -54.689 -19.756 1.00 98.52  ? 129 GLU A O   1 
ATOM   826  C CB  . GLU A 1 117 ? 17.542  -55.712 -16.842 1.00 104.92 ? 129 GLU A CB  1 
ATOM   827  C CG  . GLU A 1 117 ? 17.368  -56.705 -15.699 1.00 111.80 ? 129 GLU A CG  1 
ATOM   828  C CD  . GLU A 1 117 ? 18.654  -57.432 -15.365 1.00 111.94 ? 129 GLU A CD  1 
ATOM   829  O OE1 . GLU A 1 117 ? 19.648  -57.218 -16.088 1.00 102.42 ? 129 GLU A OE1 1 
ATOM   830  O OE2 . GLU A 1 117 ? 18.656  -58.206 -14.387 1.00 114.60 ? 129 GLU A OE2 1 
ATOM   831  N N   . PRO A 1 118 ? 15.609  -54.332 -19.297 1.00 99.00  ? 130 PRO A N   1 
ATOM   832  C CA  . PRO A 1 118 ? 15.448  -53.240 -20.260 1.00 95.83  ? 130 PRO A CA  1 
ATOM   833  C C   . PRO A 1 118 ? 16.219  -51.935 -20.064 1.00 94.40  ? 130 PRO A C   1 
ATOM   834  O O   . PRO A 1 118 ? 16.705  -51.374 -21.063 1.00 92.85  ? 130 PRO A O   1 
ATOM   835  C CB  . PRO A 1 118 ? 13.923  -53.020 -20.194 1.00 101.04 ? 130 PRO A CB  1 
ATOM   836  C CG  . PRO A 1 118 ? 13.555  -53.402 -18.784 1.00 95.61  ? 130 PRO A CG  1 
ATOM   837  C CD  . PRO A 1 118 ? 14.402  -54.630 -18.545 1.00 95.47  ? 130 PRO A CD  1 
ATOM   838  N N   . ASN A 1 119 ? 16.326  -51.461 -18.821 1.00 94.91  ? 131 ASN A N   1 
ATOM   839  C CA  . ASN A 1 119 ? 16.966  -50.146 -18.527 1.00 95.23  ? 131 ASN A CA  1 
ATOM   840  C C   . ASN A 1 119 ? 18.438  -50.397 -18.200 1.00 93.90  ? 131 ASN A C   1 
ATOM   841  O O   . ASN A 1 119 ? 19.148  -49.430 -17.857 1.00 92.42  ? 131 ASN A O   1 
ATOM   842  C CB  . ASN A 1 119 ? 16.210  -49.377 -17.452 1.00 96.47  ? 131 ASN A CB  1 
ATOM   843  C CG  . ASN A 1 119 ? 16.308  -47.882 -17.638 1.00 98.04  ? 131 ASN A CG  1 
ATOM   844  O OD1 . ASN A 1 119 ? 16.998  -47.206 -16.867 1.00 103.45 ? 131 ASN A OD1 1 
ATOM   845  N ND2 . ASN A 1 119 ? 15.628  -47.349 -18.642 1.00 86.15  ? 131 ASN A ND2 1 
ATOM   846  N N   . LYS A 1 120 ? 18.890  -51.635 -18.378 1.00 95.52  ? 132 LYS A N   1 
ATOM   847  C CA  . LYS A 1 120 ? 20.276  -52.026 -18.019 1.00 93.79  ? 132 LYS A CA  1 
ATOM   848  C C   . LYS A 1 120 ? 21.218  -51.148 -18.849 1.00 90.76  ? 132 LYS A C   1 
ATOM   849  O O   . LYS A 1 120 ? 22.261  -50.739 -18.316 1.00 94.03  ? 132 LYS A O   1 
ATOM   850  C CB  . LYS A 1 120 ? 20.452  -53.529 -18.255 1.00 94.82  ? 132 LYS A CB  1 
ATOM   851  C CG  . LYS A 1 120 ? 21.867  -54.014 -18.507 1.00 87.70  ? 132 LYS A CG  1 
ATOM   852  C CD  . LYS A 1 120 ? 22.460  -54.774 -17.328 1.00 86.04  ? 132 LYS A CD  1 
ATOM   853  C CE  . LYS A 1 120 ? 23.674  -55.543 -17.732 1.00 88.88  ? 132 LYS A CE  1 
ATOM   854  N NZ  . LYS A 1 120 ? 23.501  -56.172 -19.044 1.00 95.90  ? 132 LYS A NZ  1 
ATOM   855  N N   . VAL A 1 121 ? 20.848  -50.828 -20.085 1.00 86.20  ? 133 VAL A N   1 
ATOM   856  C CA  . VAL A 1 121 ? 21.778  -50.070 -20.967 1.00 91.83  ? 133 VAL A CA  1 
ATOM   857  C C   . VAL A 1 121 ? 22.099  -48.728 -20.293 1.00 93.81  ? 133 VAL A C   1 
ATOM   858  O O   . VAL A 1 121 ? 23.281  -48.339 -20.322 1.00 94.82  ? 133 VAL A O   1 
ATOM   859  C CB  . VAL A 1 121 ? 21.102  -49.860 -22.332 1.00 95.51  ? 133 VAL A CB  1 
ATOM   860  C CG1 . VAL A 1 121 ? 19.842  -49.013 -22.204 1.00 94.68  ? 133 VAL A CG1 1 
ATOM   861  C CG2 . VAL A 1 121 ? 22.049  -49.263 -23.366 1.00 90.83  ? 133 VAL A CG2 1 
ATOM   862  N N   . THR A 1 122 ? 21.135  -48.065 -19.655 1.00 91.59  ? 134 THR A N   1 
ATOM   863  C CA  . THR A 1 122 ? 21.483  -46.749 -19.083 1.00 93.42  ? 134 THR A CA  1 
ATOM   864  C C   . THR A 1 122 ? 22.565  -46.939 -18.039 1.00 95.12  ? 134 THR A C   1 
ATOM   865  O O   . THR A 1 122 ? 23.512  -46.124 -18.026 1.00 99.08  ? 134 THR A O   1 
ATOM   866  C CB  . THR A 1 122 ? 20.228  -46.129 -18.476 1.00 94.19  ? 134 THR A CB  1 
ATOM   867  O OG1 . THR A 1 122 ? 19.950  -46.896 -17.310 1.00 91.68  ? 134 THR A OG1 1 
ATOM   868  C CG2 . THR A 1 122 ? 19.042  -46.195 -19.419 1.00 89.14  ? 134 THR A CG2 1 
ATOM   869  N N   . THR A 1 123 ? 22.458  -47.975 -17.202 1.00 93.55  ? 135 THR A N   1 
ATOM   870  C CA  . THR A 1 123 ? 23.518  -48.290 -16.210 1.00 92.00  ? 135 THR A CA  1 
ATOM   871  C C   . THR A 1 123 ? 24.818  -48.679 -16.895 1.00 87.83  ? 135 THR A C   1 
ATOM   872  O O   . THR A 1 123 ? 25.868  -48.359 -16.341 1.00 84.56  ? 135 THR A O   1 
ATOM   873  C CB  . THR A 1 123 ? 23.051  -49.343 -15.204 1.00 90.29  ? 135 THR A CB  1 
ATOM   874  O OG1 . THR A 1 123 ? 22.536  -50.446 -15.940 1.00 91.40  ? 135 THR A OG1 1 
ATOM   875  C CG2 . THR A 1 123 ? 21.983  -48.797 -14.274 1.00 89.40  ? 135 THR A CG2 1 
ATOM   876  N N   . VAL A 1 124 ? 24.774  -49.427 -17.998 1.00 90.45  ? 136 VAL A N   1 
ATOM   877  C CA  . VAL A 1 124 ? 26.025  -49.955 -18.640 1.00 89.05  ? 136 VAL A CA  1 
ATOM   878  C C   . VAL A 1 124 ? 26.968  -48.851 -19.161 1.00 93.26  ? 136 VAL A C   1 
ATOM   879  O O   . VAL A 1 124 ? 28.181  -49.115 -19.144 1.00 97.55  ? 136 VAL A O   1 
ATOM   880  C CB  . VAL A 1 124 ? 25.812  -51.036 -19.724 1.00 88.38  ? 136 VAL A CB  1 
ATOM   881  C CG1 . VAL A 1 124 ? 24.878  -52.148 -19.272 1.00 89.46  ? 136 VAL A CG1 1 
ATOM   882  C CG2 . VAL A 1 124 ? 25.416  -50.475 -21.084 1.00 93.72  ? 136 VAL A CG2 1 
ATOM   883  N N   . LEU A 1 125 ? 26.476  -47.744 -19.730 1.00 96.39  ? 137 LEU A N   1 
ATOM   884  C CA  . LEU A 1 125 ? 27.416  -46.780 -20.380 1.00 102.90 ? 137 LEU A CA  1 
ATOM   885  C C   . LEU A 1 125 ? 28.285  -45.967 -19.392 1.00 101.34 ? 137 LEU A C   1 
ATOM   886  O O   . LEU A 1 125 ? 29.370  -46.461 -19.041 1.00 94.87  ? 137 LEU A O   1 
ATOM   887  C CB  . LEU A 1 125 ? 26.612  -45.847 -21.284 1.00 95.56  ? 137 LEU A CB  1 
ATOM   888  C CG  . LEU A 1 125 ? 25.224  -46.341 -21.695 1.00 95.82  ? 137 LEU A CG  1 
ATOM   889  C CD1 . LEU A 1 125 ? 24.199  -45.224 -21.628 1.00 95.52  ? 137 LEU A CD1 1 
ATOM   890  C CD2 . LEU A 1 125 ? 25.254  -46.965 -23.078 1.00 104.98 ? 137 LEU A CD2 1 
ATOM   891  N N   . ASP A 1 126 ? 27.919  -44.713 -19.102 1.00 100.92 ? 138 ASP A N   1 
ATOM   892  C CA  . ASP A 1 126 ? 28.689  -43.851 -18.152 1.00 89.61  ? 138 ASP A CA  1 
ATOM   893  C C   . ASP A 1 126 ? 28.648  -44.372 -16.712 1.00 90.65  ? 138 ASP A C   1 
ATOM   894  O O   . ASP A 1 126 ? 29.691  -44.307 -16.034 1.00 94.20  ? 138 ASP A O   1 
ATOM   895  C CB  . ASP A 1 126 ? 28.258  -42.395 -18.223 1.00 89.09  ? 138 ASP A CB  1 
ATOM   896  C CG  . ASP A 1 126 ? 26.761  -42.171 -18.331 1.00 98.84  ? 138 ASP A CG  1 
ATOM   897  O OD1 . ASP A 1 126 ? 26.133  -41.915 -17.284 1.00 97.49  ? 138 ASP A OD1 1 
ATOM   898  O OD2 . ASP A 1 126 ? 26.242  -42.271 -19.460 1.00 95.11  ? 138 ASP A OD2 1 
ATOM   899  N N   . THR A 1 127 ? 27.490  -44.855 -16.258 1.00 86.00  ? 139 THR A N   1 
ATOM   900  C CA  . THR A 1 127 ? 27.329  -45.251 -14.834 1.00 83.16  ? 139 THR A CA  1 
ATOM   901  C C   . THR A 1 127 ? 28.470  -46.116 -14.305 1.00 86.46  ? 139 THR A C   1 
ATOM   902  O O   . THR A 1 127 ? 28.961  -45.775 -13.209 1.00 84.69  ? 139 THR A O   1 
ATOM   903  C CB  . THR A 1 127 ? 25.954  -45.885 -14.633 1.00 87.20  ? 139 THR A CB  1 
ATOM   904  O OG1 . THR A 1 127 ? 25.040  -44.984 -15.250 1.00 88.22  ? 139 THR A OG1 1 
ATOM   905  C CG2 . THR A 1 127 ? 25.598  -46.063 -13.170 1.00 80.89  ? 139 THR A CG2 1 
ATOM   906  N N   . PRO A 1 128 ? 28.962  -47.197 -14.961 1.00 86.05  ? 140 PRO A N   1 
ATOM   907  C CA  . PRO A 1 128 ? 30.040  -47.994 -14.350 1.00 89.74  ? 140 PRO A CA  1 
ATOM   908  C C   . PRO A 1 128 ? 31.271  -47.153 -14.061 1.00 90.88  ? 140 PRO A C   1 
ATOM   909  O O   . PRO A 1 128 ? 31.758  -47.127 -12.926 1.00 90.63  ? 140 PRO A O   1 
ATOM   910  C CB  . PRO A 1 128 ? 30.335  -49.078 -15.395 1.00 98.18  ? 140 PRO A CB  1 
ATOM   911  C CG  . PRO A 1 128 ? 29.840  -48.541 -16.680 1.00 91.88  ? 140 PRO A CG  1 
ATOM   912  C CD  . PRO A 1 128 ? 28.717  -47.601 -16.364 1.00 90.40  ? 140 PRO A CD  1 
ATOM   913  N N   . ILE A 1 129 ? 31.775  -46.467 -15.088 1.00 86.04  ? 141 ILE A N   1 
ATOM   914  C CA  . ILE A 1 129 ? 32.849  -45.498 -14.933 1.00 80.94  ? 141 ILE A CA  1 
ATOM   915  C C   . ILE A 1 129 ? 32.647  -44.659 -13.674 1.00 84.96  ? 141 ILE A C   1 
ATOM   916  O O   . ILE A 1 129 ? 33.541  -44.588 -12.831 1.00 93.72  ? 141 ILE A O   1 
ATOM   917  C CB  . ILE A 1 129 ? 32.965  -44.600 -16.172 1.00 76.37  ? 141 ILE A CB  1 
ATOM   918  C CG1 . ILE A 1 129 ? 33.532  -45.381 -17.348 1.00 77.68  ? 141 ILE A CG1 1 
ATOM   919  C CG2 . ILE A 1 129 ? 33.816  -43.393 -15.872 1.00 82.03  ? 141 ILE A CG2 1 
ATOM   920  C CD1 . ILE A 1 129 ? 33.560  -44.583 -18.601 1.00 77.09  ? 141 ILE A CD1 1 
ATOM   921  N N   . ILE A 1 130 ? 31.467  -44.056 -13.502 1.00 82.58  ? 142 ILE A N   1 
ATOM   922  C CA  . ILE A 1 130 ? 31.253  -43.145 -12.376 1.00 80.80  ? 142 ILE A CA  1 
ATOM   923  C C   . ILE A 1 130 ? 31.230  -43.897 -11.054 1.00 80.23  ? 142 ILE A C   1 
ATOM   924  O O   . ILE A 1 130 ? 31.931  -43.528 -10.107 1.00 83.61  ? 142 ILE A O   1 
ATOM   925  C CB  . ILE A 1 130 ? 29.965  -42.327 -12.562 1.00 77.85  ? 142 ILE A CB  1 
ATOM   926  C CG1 . ILE A 1 130 ? 30.157  -41.321 -13.682 1.00 73.73  ? 142 ILE A CG1 1 
ATOM   927  C CG2 . ILE A 1 130 ? 29.581  -41.620 -11.266 1.00 68.94  ? 142 ILE A CG2 1 
ATOM   928  C CD1 . ILE A 1 130 ? 28.920  -40.647 -14.030 1.00 74.09  ? 142 ILE A CD1 1 
ATOM   929  N N   . ILE A 1 131 ? 30.399  -44.928 -10.941 1.00 75.47  ? 143 ILE A N   1 
ATOM   930  C CA  . ILE A 1 131 ? 30.262  -45.506 -9.615  1.00 82.32  ? 143 ILE A CA  1 
ATOM   931  C C   . ILE A 1 131 ? 31.471  -46.346 -9.259  1.00 84.60  ? 143 ILE A C   1 
ATOM   932  O O   . ILE A 1 131 ? 31.706  -46.615 -8.074  1.00 88.70  ? 143 ILE A O   1 
ATOM   933  C CB  . ILE A 1 131 ? 28.961  -46.307 -9.498  1.00 87.42  ? 143 ILE A CB  1 
ATOM   934  C CG1 . ILE A 1 131 ? 27.770  -45.389 -9.768  1.00 80.19  ? 143 ILE A CG1 1 
ATOM   935  C CG2 . ILE A 1 131 ? 28.820  -46.888 -8.114  1.00 87.93  ? 143 ILE A CG2 1 
ATOM   936  C CD1 . ILE A 1 131 ? 26.436  -46.067 -9.668  1.00 81.93  ? 143 ILE A CD1 1 
ATOM   937  N N   . SER A 1 132 ? 32.260  -46.759 -10.247 1.00 83.96  ? 144 SER A N   1 
ATOM   938  C CA  . SER A 1 132 ? 33.595  -47.255 -9.932  1.00 90.21  ? 144 SER A CA  1 
ATOM   939  C C   . SER A 1 132 ? 34.401  -46.172 -9.217  1.00 89.64  ? 144 SER A C   1 
ATOM   940  O O   . SER A 1 132 ? 34.746  -46.304 -8.034  1.00 81.81  ? 144 SER A O   1 
ATOM   941  C CB  . SER A 1 132 ? 34.303  -47.708 -11.212 1.00 90.24  ? 144 SER A CB  1 
ATOM   942  O OG  . SER A 1 132 ? 33.738  -48.931 -11.686 1.00 98.94  ? 144 SER A OG  1 
ATOM   943  N N   . TRP A 1 133 ? 34.666  -45.068 -9.926  1.00 92.64  ? 145 TRP A N   1 
ATOM   944  C CA  . TRP A 1 133 ? 35.433  -43.953 -9.383  1.00 87.49  ? 145 TRP A CA  1 
ATOM   945  C C   . TRP A 1 133 ? 34.961  -43.600 -7.985  1.00 83.60  ? 145 TRP A C   1 
ATOM   946  O O   . TRP A 1 133 ? 35.753  -43.533 -7.046  1.00 85.39  ? 145 TRP A O   1 
ATOM   947  C CB  . TRP A 1 133 ? 35.314  -42.753 -10.320 1.00 80.32  ? 145 TRP A CB  1 
ATOM   948  C CG  . TRP A 1 133 ? 35.921  -41.526 -9.782  1.00 88.61  ? 145 TRP A CG  1 
ATOM   949  C CD1 . TRP A 1 133 ? 37.188  -41.064 -10.028 1.00 93.40  ? 145 TRP A CD1 1 
ATOM   950  C CD2 . TRP A 1 133 ? 35.305  -40.573 -8.917  1.00 85.07  ? 145 TRP A CD2 1 
ATOM   951  N NE1 . TRP A 1 133 ? 37.396  -39.887 -9.353  1.00 89.29  ? 145 TRP A NE1 1 
ATOM   952  C CE2 . TRP A 1 133 ? 36.252  -39.561 -8.668  1.00 84.09  ? 145 TRP A CE2 1 
ATOM   953  C CE3 . TRP A 1 133 ? 34.043  -40.473 -8.332  1.00 86.64  ? 145 TRP A CE3 1 
ATOM   954  C CZ2 . TRP A 1 133 ? 35.974  -38.465 -7.850  1.00 81.49  ? 145 TRP A CZ2 1 
ATOM   955  C CZ3 . TRP A 1 133 ? 33.769  -39.387 -7.517  1.00 87.65  ? 145 TRP A CZ3 1 
ATOM   956  C CH2 . TRP A 1 133 ? 34.733  -38.397 -7.284  1.00 84.02  ? 145 TRP A CH2 1 
ATOM   957  N N   . ALA A 1 134 ? 33.657  -43.423 -7.821  1.00 84.53  ? 146 ALA A N   1 
ATOM   958  C CA  . ALA A 1 134 ? 33.087  -43.158 -6.507  1.00 88.82  ? 146 ALA A CA  1 
ATOM   959  C C   . ALA A 1 134 ? 33.409  -44.248 -5.502  1.00 83.40  ? 146 ALA A C   1 
ATOM   960  O O   . ALA A 1 134 ? 33.298  -44.022 -4.296  1.00 82.77  ? 146 ALA A O   1 
ATOM   961  C CB  . ALA A 1 134 ? 31.571  -43.006 -6.623  1.00 96.25  ? 146 ALA A CB  1 
ATOM   962  N N   . LEU A 1 135 ? 33.796  -45.424 -5.962  1.00 78.91  ? 147 LEU A N   1 
ATOM   963  C CA  . LEU A 1 135 ? 34.120  -46.486 -5.036  1.00 82.88  ? 147 LEU A CA  1 
ATOM   964  C C   . LEU A 1 135 ? 35.624  -46.668 -4.944  1.00 82.31  ? 147 LEU A C   1 
ATOM   965  O O   . LEU A 1 135 ? 36.161  -46.836 -3.845  1.00 79.09  ? 147 LEU A O   1 
ATOM   966  C CB  . LEU A 1 135 ? 33.419  -47.779 -5.472  1.00 86.07  ? 147 LEU A CB  1 
ATOM   967  C CG  . LEU A 1 135 ? 31.898  -47.890 -5.194  1.00 83.29  ? 147 LEU A CG  1 
ATOM   968  C CD1 . LEU A 1 135 ? 31.281  -49.164 -5.774  1.00 76.22  ? 147 LEU A CD1 1 
ATOM   969  C CD2 . LEU A 1 135 ? 31.591  -47.805 -3.722  1.00 80.70  ? 147 LEU A CD2 1 
ATOM   970  N N   . GLN A 1 136 ? 36.319  -46.544 -6.077  1.00 83.59  ? 148 GLN A N   1 
ATOM   971  C CA  . GLN A 1 136 ? 37.775  -46.443 -6.118  1.00 83.26  ? 148 GLN A CA  1 
ATOM   972  C C   . GLN A 1 136 ? 38.306  -45.265 -5.325  1.00 86.95  ? 148 GLN A C   1 
ATOM   973  O O   . GLN A 1 136 ? 39.523  -45.088 -5.227  1.00 88.19  ? 148 GLN A O   1 
ATOM   974  C CB  . GLN A 1 136 ? 38.280  -46.295 -7.544  1.00 82.92  ? 148 GLN A CB  1 
ATOM   975  C CG  . GLN A 1 136 ? 38.282  -47.562 -8.325  1.00 90.42  ? 148 GLN A CG  1 
ATOM   976  C CD  . GLN A 1 136 ? 38.889  -47.359 -9.695  1.00 100.58 ? 148 GLN A CD  1 
ATOM   977  O OE1 . GLN A 1 136 ? 39.451  -46.291 -9.977  1.00 108.27 ? 148 GLN A OE1 1 
ATOM   978  N NE2 . GLN A 1 136 ? 38.827  -48.390 -10.541 1.00 96.74  ? 148 GLN A NE2 1 
ATOM   979  N N   . GLN A 1 137 ? 37.411  -44.421 -4.813  1.00 87.74  ? 149 GLN A N   1 
ATOM   980  C CA  . GLN A 1 137 ? 37.785  -43.346 -3.909  1.00 82.04  ? 149 GLN A CA  1 
ATOM   981  C C   . GLN A 1 137 ? 37.211  -43.587 -2.522  1.00 83.26  ? 149 GLN A C   1 
ATOM   982  O O   . GLN A 1 137 ? 37.328  -42.722 -1.657  1.00 95.98  ? 149 GLN A O   1 
ATOM   983  C CB  . GLN A 1 137 ? 37.327  -41.986 -4.451  1.00 74.19  ? 149 GLN A CB  1 
ATOM   984  C CG  . GLN A 1 137 ? 37.763  -41.656 -5.883  1.00 79.69  ? 149 GLN A CG  1 
ATOM   985  C CD  . GLN A 1 137 ? 39.181  -41.130 -6.051  1.00 84.87  ? 149 GLN A CD  1 
ATOM   986  O OE1 . GLN A 1 137 ? 39.439  -39.938 -5.842  1.00 84.90  ? 149 GLN A OE1 1 
ATOM   987  N NE2 . GLN A 1 137 ? 40.100  -42.003 -6.483  1.00 86.46  ? 149 GLN A NE2 1 
ATOM   988  N N   . GLY A 1 138 ? 36.595  -44.738 -2.286  1.00 75.85  ? 150 GLY A N   1 
ATOM   989  C CA  . GLY A 1 138 ? 36.180  -45.062 -0.937  1.00 84.48  ? 150 GLY A CA  1 
ATOM   990  C C   . GLY A 1 138 ? 34.942  -44.342 -0.467  1.00 86.86  ? 150 GLY A C   1 
ATOM   991  O O   . GLY A 1 138 ? 34.733  -44.197 0.743   1.00 92.05  ? 150 GLY A O   1 
ATOM   992  N N   . TYR A 1 139 ? 34.119  -43.869 -1.387  1.00 86.85  ? 151 TYR A N   1 
ATOM   993  C CA  . TYR A 1 139 ? 32.822  -43.313 -1.051  1.00 90.29  ? 151 TYR A CA  1 
ATOM   994  C C   . TYR A 1 139 ? 31.773  -44.424 -1.137  1.00 91.90  ? 151 TYR A C   1 
ATOM   995  O O   . TYR A 1 139 ? 31.727  -45.167 -2.125  1.00 91.76  ? 151 TYR A O   1 
ATOM   996  C CB  . TYR A 1 139 ? 32.468  -42.173 -2.015  1.00 89.55  ? 151 TYR A CB  1 
ATOM   997  C CG  . TYR A 1 139 ? 33.539  -41.107 -2.309  1.00 91.19  ? 151 TYR A CG  1 
ATOM   998  C CD1 . TYR A 1 139 ? 34.258  -40.476 -1.305  1.00 92.09  ? 151 TYR A CD1 1 
ATOM   999  C CD2 . TYR A 1 139 ? 33.856  -40.774 -3.627  1.00 92.51  ? 151 TYR A CD2 1 
ATOM   1000 C CE1 . TYR A 1 139 ? 35.241  -39.505 -1.619  1.00 91.68  ? 151 TYR A CE1 1 
ATOM   1001 C CE2 . TYR A 1 139 ? 34.828  -39.823 -3.939  1.00 87.30  ? 151 TYR A CE2 1 
ATOM   1002 C CZ  . TYR A 1 139 ? 35.522  -39.195 -2.941  1.00 87.70  ? 151 TYR A CZ  1 
ATOM   1003 O OH  . TYR A 1 139 ? 36.487  -38.251 -3.270  1.00 91.77  ? 151 TYR A OH  1 
ATOM   1004 N N   . TYR A 1 140 ? 30.952  -44.549 -0.098  1.00 86.35  ? 152 TYR A N   1 
ATOM   1005 C CA  . TYR A 1 140 ? 29.745  -45.367 -0.157  1.00 85.07  ? 152 TYR A CA  1 
ATOM   1006 C C   . TYR A 1 140 ? 28.842  -44.833 -1.248  1.00 86.09  ? 152 TYR A C   1 
ATOM   1007 O O   . TYR A 1 140 ? 28.588  -43.629 -1.299  1.00 92.61  ? 152 TYR A O   1 
ATOM   1008 C CB  . TYR A 1 140 ? 29.011  -45.251 1.161   1.00 94.19  ? 152 TYR A CB  1 
ATOM   1009 C CG  . TYR A 1 140 ? 29.856  -45.675 2.294   1.00 101.36 ? 152 TYR A CG  1 
ATOM   1010 C CD1 . TYR A 1 140 ? 30.730  -44.774 2.869   1.00 107.16 ? 152 TYR A CD1 1 
ATOM   1011 C CD2 . TYR A 1 140 ? 29.738  -46.931 2.841   1.00 100.90 ? 152 TYR A CD2 1 
ATOM   1012 C CE1 . TYR A 1 140 ? 31.519  -45.128 3.897   1.00 116.41 ? 152 TYR A CE1 1 
ATOM   1013 C CE2 . TYR A 1 140 ? 30.512  -47.299 3.890   1.00 107.07 ? 152 TYR A CE2 1 
ATOM   1014 C CZ  . TYR A 1 140 ? 31.403  -46.390 4.418   1.00 120.22 ? 152 TYR A CZ  1 
ATOM   1015 O OH  . TYR A 1 140 ? 32.199  -46.730 5.478   1.00 134.96 ? 152 TYR A OH  1 
ATOM   1016 N N   . VAL A 1 141 ? 28.328  -45.700 -2.111  1.00 82.66  ? 153 VAL A N   1 
ATOM   1017 C CA  . VAL A 1 141 ? 27.476  -45.243 -3.203  1.00 79.04  ? 153 VAL A CA  1 
ATOM   1018 C C   . VAL A 1 141 ? 26.026  -45.555 -2.854  1.00 80.95  ? 153 VAL A C   1 
ATOM   1019 O O   . VAL A 1 141 ? 25.740  -46.576 -2.224  1.00 86.53  ? 153 VAL A O   1 
ATOM   1020 C CB  . VAL A 1 141 ? 27.869  -45.886 -4.546  1.00 75.38  ? 153 VAL A CB  1 
ATOM   1021 C CG1 . VAL A 1 141 ? 26.848  -45.528 -5.584  1.00 79.51  ? 153 VAL A CG1 1 
ATOM   1022 C CG2 . VAL A 1 141 ? 29.252  -45.446 -4.997  1.00 76.35  ? 153 VAL A CG2 1 
ATOM   1023 N N   . VAL A 1 142 ? 25.110  -44.665 -3.230  1.00 81.14  ? 154 VAL A N   1 
ATOM   1024 C CA  . VAL A 1 142 ? 23.690  -45.005 -3.309  1.00 85.45  ? 154 VAL A CA  1 
ATOM   1025 C C   . VAL A 1 142 ? 23.154  -44.470 -4.621  1.00 85.86  ? 154 VAL A C   1 
ATOM   1026 O O   . VAL A 1 142 ? 23.482  -43.351 -5.025  1.00 84.07  ? 154 VAL A O   1 
ATOM   1027 C CB  . VAL A 1 142 ? 22.838  -44.444 -2.153  1.00 82.96  ? 154 VAL A CB  1 
ATOM   1028 C CG1 . VAL A 1 142 ? 23.149  -42.997 -1.940  1.00 92.61  ? 154 VAL A CG1 1 
ATOM   1029 C CG2 . VAL A 1 142 ? 21.349  -44.652 -2.410  1.00 76.81  ? 154 VAL A CG2 1 
ATOM   1030 N N   . SER A 1 143 ? 22.357  -45.283 -5.299  1.00 90.27  ? 155 SER A N   1 
ATOM   1031 C CA  . SER A 1 143 ? 21.520  -44.857 -6.408  1.00 87.14  ? 155 SER A CA  1 
ATOM   1032 C C   . SER A 1 143 ? 20.122  -45.300 -6.063  1.00 87.06  ? 155 SER A C   1 
ATOM   1033 O O   . SER A 1 143 ? 19.949  -46.327 -5.407  1.00 91.33  ? 155 SER A O   1 
ATOM   1034 C CB  . SER A 1 143 ? 21.948  -45.459 -7.734  1.00 86.09  ? 155 SER A CB  1 
ATOM   1035 O OG  . SER A 1 143 ? 21.637  -44.580 -8.788  1.00 84.56  ? 155 SER A OG  1 
ATOM   1036 N N   . SER A 1 144 ? 19.123  -44.538 -6.472  1.00 87.97  ? 156 SER A N   1 
ATOM   1037 C CA  . SER A 1 144 ? 17.800  -44.821 -5.945  1.00 95.99  ? 156 SER A CA  1 
ATOM   1038 C C   . SER A 1 144 ? 16.796  -44.725 -7.088  1.00 91.60  ? 156 SER A C   1 
ATOM   1039 O O   . SER A 1 144 ? 16.946  -43.908 -8.005  1.00 84.67  ? 156 SER A O   1 
ATOM   1040 C CB  . SER A 1 144 ? 17.487  -43.870 -4.741  1.00 93.86  ? 156 SER A CB  1 
ATOM   1041 O OG  . SER A 1 144 ? 16.178  -44.018 -4.219  1.00 94.99  ? 156 SER A OG  1 
ATOM   1042 N N   . ASP A 1 145 ? 15.813  -45.624 -7.066  1.00 91.61  ? 157 ASP A N   1 
ATOM   1043 C CA  . ASP A 1 145 ? 14.691  -45.573 -8.009  1.00 95.96  ? 157 ASP A CA  1 
ATOM   1044 C C   . ASP A 1 145 ? 13.881  -44.306 -7.763  1.00 89.92  ? 157 ASP A C   1 
ATOM   1045 O O   . ASP A 1 145 ? 12.880  -44.302 -7.036  1.00 79.93  ? 157 ASP A O   1 
ATOM   1046 C CB  . ASP A 1 145 ? 13.857  -46.842 -7.901  1.00 102.24 ? 157 ASP A CB  1 
ATOM   1047 C CG  . ASP A 1 145 ? 14.723  -48.124 -7.917  1.00 99.28  ? 157 ASP A CG  1 
ATOM   1048 O OD1 . ASP A 1 145 ? 15.783  -48.117 -8.596  1.00 92.48  ? 157 ASP A OD1 1 
ATOM   1049 O OD2 . ASP A 1 145 ? 14.355  -49.122 -7.243  1.00 94.23  ? 157 ASP A OD2 1 
ATOM   1050 N N   . HIS A 1 146 ? 14.327  -43.224 -8.432  1.00 89.21  ? 158 HIS A N   1 
ATOM   1051 C CA  . HIS A 1 146 ? 13.890  -41.861 -8.118  1.00 85.69  ? 158 HIS A CA  1 
ATOM   1052 C C   . HIS A 1 146 ? 12.460  -41.607 -8.554  1.00 89.59  ? 158 HIS A C   1 
ATOM   1053 O O   . HIS A 1 146 ? 11.773  -40.770 -7.959  1.00 84.24  ? 158 HIS A O   1 
ATOM   1054 C CB  . HIS A 1 146 ? 14.821  -40.849 -8.778  1.00 80.15  ? 158 HIS A CB  1 
ATOM   1055 C CG  . HIS A 1 146 ? 15.225  -41.195 -10.179 1.00 81.47  ? 158 HIS A CG  1 
ATOM   1056 N ND1 . HIS A 1 146 ? 14.393  -41.011 -11.263 1.00 93.45  ? 158 HIS A ND1 1 
ATOM   1057 C CD2 . HIS A 1 146 ? 16.379  -41.700 -10.678 1.00 78.81  ? 158 HIS A CD2 1 
ATOM   1058 C CE1 . HIS A 1 146 ? 15.020  -41.377 -12.368 1.00 91.12  ? 158 HIS A CE1 1 
ATOM   1059 N NE2 . HIS A 1 146 ? 16.232  -41.789 -12.041 1.00 80.31  ? 158 HIS A NE2 1 
ATOM   1060 N N   . GLU A 1 147 ? 11.985  -42.395 -9.521  1.00 91.42  ? 159 GLU A N   1 
ATOM   1061 C CA  . GLU A 1 147 ? 10.568  -42.287 -9.947  1.00 80.38  ? 159 GLU A CA  1 
ATOM   1062 C C   . GLU A 1 147 ? 9.702   -43.058 -8.942  1.00 81.14  ? 159 GLU A C   1 
ATOM   1063 O O   . GLU A 1 147 ? 8.537   -42.658 -8.740  1.00 80.56  ? 159 GLU A O   1 
ATOM   1064 C CB  . GLU A 1 147 ? 10.446  -42.842 -11.362 1.00 80.57  ? 159 GLU A CB  1 
ATOM   1065 C CG  . GLU A 1 147 ? 11.691  -42.613 -12.210 1.00 80.60  ? 159 GLU A CG  1 
ATOM   1066 C CD  . GLU A 1 147 ? 11.327  -42.397 -13.664 1.00 83.25  ? 159 GLU A CD  1 
ATOM   1067 O OE1 . GLU A 1 147 ? 10.114  -42.466 -13.940 1.00 85.20  ? 159 GLU A OE1 1 
ATOM   1068 O OE2 . GLU A 1 147 ? 12.223  -42.166 -14.502 1.00 78.16  ? 159 GLU A OE2 1 
ATOM   1069 N N   . GLY A 1 148 ? 10.249  -44.119 -8.340  1.00 83.41  ? 160 GLY A N   1 
ATOM   1070 C CA  . GLY A 1 148 ? 9.514   -44.855 -7.290  1.00 92.50  ? 160 GLY A CA  1 
ATOM   1071 C C   . GLY A 1 148 ? 8.466   -45.813 -7.817  1.00 87.63  ? 160 GLY A C   1 
ATOM   1072 O O   . GLY A 1 148 ? 8.512   -46.155 -9.015  1.00 88.08  ? 160 GLY A O   1 
ATOM   1073 N N   . PRO A 1 149 ? 7.523   -46.267 -6.964  1.00 84.70  ? 161 PRO A N   1 
ATOM   1074 C CA  . PRO A 1 149 ? 6.475   -47.199 -7.365  1.00 86.85  ? 161 PRO A CA  1 
ATOM   1075 C C   . PRO A 1 149 ? 5.638   -46.526 -8.432  1.00 91.62  ? 161 PRO A C   1 
ATOM   1076 O O   . PRO A 1 149 ? 5.216   -47.194 -9.395  1.00 90.99  ? 161 PRO A O   1 
ATOM   1077 C CB  . PRO A 1 149 ? 5.686   -47.479 -6.083  1.00 92.25  ? 161 PRO A CB  1 
ATOM   1078 C CG  . PRO A 1 149 ? 6.055   -46.345 -5.155  1.00 87.97  ? 161 PRO A CG  1 
ATOM   1079 C CD  . PRO A 1 149 ? 7.449   -45.905 -5.560  1.00 86.52  ? 161 PRO A CD  1 
ATOM   1080 N N   . ARG A 1 150 ? 5.419   -45.223 -8.280  1.00 85.53  ? 162 ARG A N   1 
ATOM   1081 C CA  . ARG A 1 150 ? 4.640   -44.442 -9.270  1.00 77.61  ? 162 ARG A CA  1 
ATOM   1082 C C   . ARG A 1 150 ? 5.388   -44.546 -10.605 1.00 78.28  ? 162 ARG A C   1 
ATOM   1083 O O   . ARG A 1 150 ? 4.702   -44.572 -11.647 1.00 80.08  ? 162 ARG A O   1 
ATOM   1084 C CB  . ARG A 1 150 ? 4.469   -42.996 -8.797  1.00 80.34  ? 162 ARG A CB  1 
ATOM   1085 C CG  . ARG A 1 150 ? 4.103   -42.899 -7.324  1.00 83.01  ? 162 ARG A CG  1 
ATOM   1086 C CD  . ARG A 1 150 ? 2.622   -42.640 -7.103  1.00 86.85  ? 162 ARG A CD  1 
ATOM   1087 N NE  . ARG A 1 150 ? 2.199   -41.334 -7.617  1.00 88.19  ? 162 ARG A NE  1 
ATOM   1088 C CZ  . ARG A 1 150 ? 1.373   -40.509 -6.985  1.00 91.34  ? 162 ARG A CZ  1 
ATOM   1089 N NH1 . ARG A 1 150 ? 1.699   -40.027 -5.800  1.00 88.67  ? 162 ARG A NH1 1 
ATOM   1090 N NH2 . ARG A 1 150 ? 0.227   -40.164 -7.546  1.00 87.50  ? 162 ARG A NH2 1 
ATOM   1091 N N   . SER A 1 151 ? 6.726   -44.570 -10.572 1.00 82.86  ? 163 SER A N   1 
ATOM   1092 C CA  . SER A 1 151 ? 7.528   -44.581 -11.824 1.00 82.21  ? 163 SER A CA  1 
ATOM   1093 C C   . SER A 1 151 ? 7.209   -43.317 -12.623 1.00 83.56  ? 163 SER A C   1 
ATOM   1094 O O   . SER A 1 151 ? 7.100   -43.398 -13.863 1.00 83.66  ? 163 SER A O   1 
ATOM   1095 C CB  . SER A 1 151 ? 7.304   -45.832 -12.637 1.00 80.85  ? 163 SER A CB  1 
ATOM   1096 O OG  . SER A 1 151 ? 7.300   -46.986 -11.809 1.00 71.60  ? 163 SER A OG  1 
ATOM   1097 N N   . ALA A 1 152 ? 7.079   -42.194 -11.912 1.00 83.69  ? 164 ALA A N   1 
ATOM   1098 C CA  . ALA A 1 152 ? 6.728   -40.929 -12.584 1.00 82.75  ? 164 ALA A CA  1 
ATOM   1099 C C   . ALA A 1 152 ? 8.004   -40.216 -13.016 1.00 77.96  ? 164 ALA A C   1 
ATOM   1100 O O   . ALA A 1 152 ? 8.732   -39.690 -12.148 1.00 78.96  ? 164 ALA A O   1 
ATOM   1101 C CB  . ALA A 1 152 ? 5.985   -40.091 -11.581 1.00 78.85  ? 164 ALA A CB  1 
ATOM   1102 N N   . PHE A 1 153 ? 8.256   -40.183 -14.326 1.00 77.06  ? 165 PHE A N   1 
ATOM   1103 C CA  . PHE A 1 153 ? 9.429   -39.450 -14.869 1.00 76.84  ? 165 PHE A CA  1 
ATOM   1104 C C   . PHE A 1 153 ? 9.171   -37.957 -14.819 1.00 76.64  ? 165 PHE A C   1 
ATOM   1105 O O   . PHE A 1 153 ? 7.998   -37.593 -15.025 1.00 80.98  ? 165 PHE A O   1 
ATOM   1106 C CB  . PHE A 1 153 ? 9.675   -39.961 -16.291 1.00 76.14  ? 165 PHE A CB  1 
ATOM   1107 C CG  . PHE A 1 153 ? 10.568  -39.095 -17.167 1.00 71.72  ? 165 PHE A CG  1 
ATOM   1108 C CD1 . PHE A 1 153 ? 11.862  -38.774 -16.775 1.00 78.46  ? 165 PHE A CD1 1 
ATOM   1109 C CD2 . PHE A 1 153 ? 10.114  -38.618 -18.390 1.00 72.21  ? 165 PHE A CD2 1 
ATOM   1110 C CE1 . PHE A 1 153 ? 12.669  -37.988 -17.580 1.00 82.95  ? 165 PHE A CE1 1 
ATOM   1111 C CE2 . PHE A 1 153 ? 10.927  -37.835 -19.192 1.00 72.86  ? 165 PHE A CE2 1 
ATOM   1112 C CZ  . PHE A 1 153 ? 12.202  -37.523 -18.787 1.00 79.04  ? 165 PHE A CZ  1 
ATOM   1113 N N   . ILE A 1 154 ? 10.169  -37.145 -14.469 1.00 76.05  ? 166 ILE A N   1 
ATOM   1114 C CA  . ILE A 1 154 ? 10.066  -35.651 -14.556 1.00 76.17  ? 166 ILE A CA  1 
ATOM   1115 C C   . ILE A 1 154 ? 9.169   -35.092 -13.435 1.00 72.84  ? 166 ILE A C   1 
ATOM   1116 O O   . ILE A 1 154 ? 8.914   -33.867 -13.436 1.00 70.21  ? 166 ILE A O   1 
ATOM   1117 C CB  . ILE A 1 154 ? 9.700   -35.190 -15.989 1.00 65.94  ? 166 ILE A CB  1 
ATOM   1118 C CG1 . ILE A 1 154 ? 10.634  -34.077 -16.465 1.00 70.28  ? 166 ILE A CG1 1 
ATOM   1119 C CG2 . ILE A 1 154 ? 8.231   -34.793 -16.152 1.00 70.00  ? 166 ILE A CG2 1 
ATOM   1120 C CD1 . ILE A 1 154 ? 12.072  -34.520 -16.653 1.00 77.12  ? 166 ILE A CD1 1 
ATOM   1121 N N   . ALA A 1 155 ? 8.724   -35.963 -12.525 1.00 71.01  ? 167 ALA A N   1 
ATOM   1122 C CA  . ALA A 1 155 ? 7.953   -35.503 -11.347 1.00 76.91  ? 167 ALA A CA  1 
ATOM   1123 C C   . ALA A 1 155 ? 8.965   -35.140 -10.269 1.00 75.05  ? 167 ALA A C   1 
ATOM   1124 O O   . ALA A 1 155 ? 9.316   -36.017 -9.454  1.00 74.86  ? 167 ALA A O   1 
ATOM   1125 C CB  . ALA A 1 155 ? 7.049   -36.602 -10.880 1.00 76.67  ? 167 ALA A CB  1 
ATOM   1126 N N   . GLY A 1 156 ? 9.402   -33.884 -10.241 1.00 75.75  ? 168 GLY A N   1 
ATOM   1127 C CA  . GLY A 1 156 ? 10.496  -33.522 -9.324  1.00 80.47  ? 168 GLY A CA  1 
ATOM   1128 C C   . GLY A 1 156 ? 10.189  -33.695 -7.853  1.00 79.73  ? 168 GLY A C   1 
ATOM   1129 O O   . GLY A 1 156 ? 11.085  -34.174 -7.133  1.00 78.74  ? 168 GLY A O   1 
ATOM   1130 N N   . TYR A 1 157 ? 8.992   -33.327 -7.395  1.00 72.15  ? 169 TYR A N   1 
ATOM   1131 C CA  . TYR A 1 157 ? 8.780   -33.409 -5.927  1.00 71.73  ? 169 TYR A CA  1 
ATOM   1132 C C   . TYR A 1 157 ? 8.902   -34.857 -5.491  1.00 83.48  ? 169 TYR A C   1 
ATOM   1133 O O   . TYR A 1 157 ? 9.592   -35.147 -4.490  1.00 90.27  ? 169 TYR A O   1 
ATOM   1134 C CB  . TYR A 1 157 ? 7.393   -32.895 -5.540  1.00 73.07  ? 169 TYR A CB  1 
ATOM   1135 C CG  . TYR A 1 157 ? 7.225   -31.389 -5.667  1.00 79.63  ? 169 TYR A CG  1 
ATOM   1136 C CD1 . TYR A 1 157 ? 7.778   -30.525 -4.731  1.00 78.45  ? 169 TYR A CD1 1 
ATOM   1137 C CD2 . TYR A 1 157 ? 6.512   -30.837 -6.722  1.00 84.49  ? 169 TYR A CD2 1 
ATOM   1138 C CE1 . TYR A 1 157 ? 7.625   -29.154 -4.839  1.00 73.25  ? 169 TYR A CE1 1 
ATOM   1139 C CE2 . TYR A 1 157 ? 6.352   -29.468 -6.839  1.00 81.25  ? 169 TYR A CE2 1 
ATOM   1140 C CZ  . TYR A 1 157 ? 6.912   -28.624 -5.898  1.00 74.93  ? 169 TYR A CZ  1 
ATOM   1141 O OH  . TYR A 1 157 ? 6.759   -27.274 -6.012  1.00 78.84  ? 169 TYR A OH  1 
ATOM   1142 N N   . GLU A 1 158 ? 8.302   -35.760 -6.268  1.00 82.52  ? 170 GLU A N   1 
ATOM   1143 C CA  . GLU A 1 158 ? 8.375   -37.198 -5.923  1.00 79.94  ? 170 GLU A CA  1 
ATOM   1144 C C   . GLU A 1 158 ? 9.829   -37.668 -5.994  1.00 77.96  ? 170 GLU A C   1 
ATOM   1145 O O   . GLU A 1 158 ? 10.284  -38.362 -5.057  1.00 82.10  ? 170 GLU A O   1 
ATOM   1146 C CB  . GLU A 1 158 ? 7.533   -37.964 -6.940  1.00 83.94  ? 170 GLU A CB  1 
ATOM   1147 C CG  . GLU A 1 158 ? 7.461   -39.462 -6.671  1.00 87.23  ? 170 GLU A CG  1 
ATOM   1148 C CD  . GLU A 1 158 ? 6.083   -39.910 -6.226  1.00 85.10  ? 170 GLU A CD  1 
ATOM   1149 O OE1 . GLU A 1 158 ? 5.102   -39.169 -6.442  1.00 77.33  ? 170 GLU A OE1 1 
ATOM   1150 O OE2 . GLU A 1 158 ? 6.003   -41.013 -5.655  1.00 86.95  ? 170 GLU A OE2 1 
ATOM   1151 N N   . GLU A 1 159 ? 10.542  -37.252 -7.042  1.00 74.43  ? 171 GLU A N   1 
ATOM   1152 C CA  . GLU A 1 159 ? 11.932  -37.738 -7.206  1.00 80.20  ? 171 GLU A CA  1 
ATOM   1153 C C   . GLU A 1 159 ? 12.791  -37.238 -6.041  1.00 83.67  ? 171 GLU A C   1 
ATOM   1154 O O   . GLU A 1 159 ? 13.540  -38.052 -5.460  1.00 86.99  ? 171 GLU A O   1 
ATOM   1155 C CB  . GLU A 1 159 ? 12.499  -37.240 -8.535  1.00 76.53  ? 171 GLU A CB  1 
ATOM   1156 C CG  . GLU A 1 159 ? 12.046  -38.068 -9.735  1.00 70.43  ? 171 GLU A CG  1 
ATOM   1157 C CD  . GLU A 1 159 ? 11.997  -37.312 -11.049 1.00 72.78  ? 171 GLU A CD  1 
ATOM   1158 O OE1 . GLU A 1 159 ? 12.876  -36.456 -11.271 1.00 76.22  ? 171 GLU A OE1 1 
ATOM   1159 O OE2 . GLU A 1 159 ? 11.080  -37.583 -11.850 1.00 74.16  ? 171 GLU A OE2 1 
ATOM   1160 N N   . GLY A 1 160 ? 12.631  -35.965 -5.675  1.00 79.85  ? 172 GLY A N   1 
ATOM   1161 C CA  . GLY A 1 160 ? 13.504  -35.411 -4.628  1.00 83.80  ? 172 GLY A CA  1 
ATOM   1162 C C   . GLY A 1 160 ? 13.294  -36.092 -3.297  1.00 84.32  ? 172 GLY A C   1 
ATOM   1163 O O   . GLY A 1 160 ? 14.298  -36.447 -2.653  1.00 83.60  ? 172 GLY A O   1 
ATOM   1164 N N   . MET A 1 161 ? 12.035  -36.330 -2.928  1.00 76.77  ? 173 MET A N   1 
ATOM   1165 C CA  . MET A 1 161 ? 11.779  -36.901 -1.583  1.00 77.57  ? 173 MET A CA  1 
ATOM   1166 C C   . MET A 1 161 ? 12.404  -38.298 -1.518  1.00 84.83  ? 173 MET A C   1 
ATOM   1167 O O   . MET A 1 161 ? 13.030  -38.625 -0.491  1.00 86.72  ? 173 MET A O   1 
ATOM   1168 C CB  . MET A 1 161 ? 10.277  -36.952 -1.287  1.00 75.24  ? 173 MET A CB  1 
ATOM   1169 C CG  . MET A 1 161 ? 9.725   -35.630 -0.793  1.00 75.73  ? 173 MET A CG  1 
ATOM   1170 S SD  . MET A 1 161 ? 7.951   -35.663 -0.473  1.00 83.46  ? 173 MET A SD  1 
ATOM   1171 C CE  . MET A 1 161 ? 7.310   -35.262 -2.104  1.00 83.76  ? 173 MET A CE  1 
ATOM   1172 N N   . ALA A 1 162 ? 12.254  -39.076 -2.591  1.00 80.91  ? 174 ALA A N   1 
ATOM   1173 C CA  . ALA A 1 162 ? 12.767  -40.461 -2.555  1.00 79.07  ? 174 ALA A CA  1 
ATOM   1174 C C   . ALA A 1 162 ? 14.285  -40.463 -2.400  1.00 81.11  ? 174 ALA A C   1 
ATOM   1175 O O   . ALA A 1 162 ? 14.805  -41.268 -1.602  1.00 80.20  ? 174 ALA A O   1 
ATOM   1176 C CB  . ALA A 1 162 ? 12.358  -41.171 -3.820  1.00 83.31  ? 174 ALA A CB  1 
ATOM   1177 N N   . ILE A 1 163 ? 14.975  -39.584 -3.131  1.00 86.47  ? 175 ILE A N   1 
ATOM   1178 C CA  . ILE A 1 163 ? 16.466  -39.629 -3.087  1.00 89.07  ? 175 ILE A CA  1 
ATOM   1179 C C   . ILE A 1 163 ? 16.942  -39.294 -1.665  1.00 92.66  ? 175 ILE A C   1 
ATOM   1180 O O   . ILE A 1 163 ? 17.808  -40.025 -1.142  1.00 94.12  ? 175 ILE A O   1 
ATOM   1181 C CB  . ILE A 1 163 ? 17.056  -38.670 -4.136  1.00 80.87  ? 175 ILE A CB  1 
ATOM   1182 C CG1 . ILE A 1 163 ? 16.782  -39.165 -5.552  1.00 74.16  ? 175 ILE A CG1 1 
ATOM   1183 C CG2 . ILE A 1 163 ? 18.549  -38.439 -3.900  1.00 85.82  ? 175 ILE A CG2 1 
ATOM   1184 C CD1 . ILE A 1 163 ? 16.659  -38.058 -6.581  1.00 71.50  ? 175 ILE A CD1 1 
ATOM   1185 N N   . LEU A 1 164 ? 16.339  -38.276 -1.046  1.00 95.00  ? 176 LEU A N   1 
ATOM   1186 C CA  . LEU A 1 164 ? 16.719  -37.896 0.337   1.00 91.87  ? 176 LEU A CA  1 
ATOM   1187 C C   . LEU A 1 164 ? 16.382  -39.051 1.281   1.00 87.26  ? 176 LEU A C   1 
ATOM   1188 O O   . LEU A 1 164 ? 17.226  -39.389 2.133   1.00 85.12  ? 176 LEU A O   1 
ATOM   1189 C CB  . LEU A 1 164 ? 15.977  -36.618 0.714   1.00 90.59  ? 176 LEU A CB  1 
ATOM   1190 C CG  . LEU A 1 164 ? 16.162  -35.446 -0.253  1.00 84.88  ? 176 LEU A CG  1 
ATOM   1191 C CD1 . LEU A 1 164 ? 15.192  -34.322 0.049   1.00 90.28  ? 176 LEU A CD1 1 
ATOM   1192 C CD2 . LEU A 1 164 ? 17.598  -34.958 -0.222  1.00 83.41  ? 176 LEU A CD2 1 
ATOM   1193 N N   . ASP A 1 165 ? 15.215  -39.665 1.079   1.00 85.93  ? 177 ASP A N   1 
ATOM   1194 C CA  . ASP A 1 165 ? 14.795  -40.805 1.935   1.00 88.25  ? 177 ASP A CA  1 
ATOM   1195 C C   . ASP A 1 165 ? 15.798  -41.938 1.727   1.00 89.84  ? 177 ASP A C   1 
ATOM   1196 O O   . ASP A 1 165 ? 16.148  -42.609 2.713   1.00 86.83  ? 177 ASP A O   1 
ATOM   1197 C CB  . ASP A 1 165 ? 13.356  -41.207 1.667   1.00 85.11  ? 177 ASP A CB  1 
ATOM   1198 C CG  . ASP A 1 165 ? 12.308  -40.375 2.390   1.00 90.30  ? 177 ASP A CG  1 
ATOM   1199 O OD1 . ASP A 1 165 ? 12.457  -40.179 3.613   1.00 96.85  ? 177 ASP A OD1 1 
ATOM   1200 O OD2 . ASP A 1 165 ? 11.357  -39.926 1.722   1.00 87.61  ? 177 ASP A OD2 1 
ATOM   1201 N N   . GLY A 1 166 ? 16.226  -42.138 0.480   1.00 85.14  ? 178 GLY A N   1 
ATOM   1202 C CA  . GLY A 1 166 ? 17.201  -43.201 0.191   1.00 84.30  ? 178 GLY A CA  1 
ATOM   1203 C C   . GLY A 1 166 ? 18.510  -42.942 0.903   1.00 97.88  ? 178 GLY A C   1 
ATOM   1204 O O   . GLY A 1 166 ? 19.082  -43.911 1.427   1.00 97.46  ? 178 GLY A O   1 
ATOM   1205 N N   . ILE A 1 167 ? 18.980  -41.691 0.928   1.00 104.46 ? 179 ILE A N   1 
ATOM   1206 C CA  . ILE A 1 167 ? 20.217  -41.372 1.705   1.00 98.11  ? 179 ILE A CA  1 
ATOM   1207 C C   . ILE A 1 167 ? 19.965  -41.623 3.202   1.00 90.95  ? 179 ILE A C   1 
ATOM   1208 O O   . ILE A 1 167 ? 20.837  -42.233 3.852   1.00 97.84  ? 179 ILE A O   1 
ATOM   1209 C CB  . ILE A 1 167 ? 20.681  -39.931 1.435   1.00 89.13  ? 179 ILE A CB  1 
ATOM   1210 C CG1 . ILE A 1 167 ? 21.009  -39.721 -0.039  1.00 88.78  ? 179 ILE A CG1 1 
ATOM   1211 C CG2 . ILE A 1 167 ? 21.862  -39.557 2.330   1.00 91.63  ? 179 ILE A CG2 1 
ATOM   1212 C CD1 . ILE A 1 167 ? 20.668  -38.335 -0.549  1.00 88.24  ? 179 ILE A CD1 1 
ATOM   1213 N N   . ARG A 1 168 ? 18.794  -41.225 3.709   1.00 87.61  ? 180 ARG A N   1 
ATOM   1214 C CA  . ARG A 1 168 ? 18.470  -41.481 5.135   1.00 92.20  ? 180 ARG A CA  1 
ATOM   1215 C C   . ARG A 1 168 ? 18.422  -42.996 5.349   1.00 99.88  ? 180 ARG A C   1 
ATOM   1216 O O   . ARG A 1 168 ? 18.948  -43.472 6.374   1.00 104.68 ? 180 ARG A O   1 
ATOM   1217 C CB  . ARG A 1 168 ? 17.111  -40.912 5.552   1.00 92.88  ? 180 ARG A CB  1 
ATOM   1218 C CG  . ARG A 1 168 ? 16.825  -39.443 5.282   1.00 91.64  ? 180 ARG A CG  1 
ATOM   1219 C CD  . ARG A 1 168 ? 15.323  -39.201 5.273   1.00 97.00  ? 180 ARG A CD  1 
ATOM   1220 N NE  . ARG A 1 168 ? 14.949  -37.819 4.958   1.00 96.50  ? 180 ARG A NE  1 
ATOM   1221 C CZ  . ARG A 1 168 ? 14.424  -36.970 5.833   1.00 94.27  ? 180 ARG A CZ  1 
ATOM   1222 N NH1 . ARG A 1 168 ? 15.077  -36.680 6.943   1.00 102.70 ? 180 ARG A NH1 1 
ATOM   1223 N NH2 . ARG A 1 168 ? 13.252  -36.411 5.594   1.00 96.14  ? 180 ARG A NH2 1 
ATOM   1224 N N   . ALA A 1 169 ? 17.831  -43.718 4.396   1.00 102.59 ? 181 ALA A N   1 
ATOM   1225 C CA  . ALA A 1 169 ? 17.773  -45.192 4.495   1.00 99.97  ? 181 ALA A CA  1 
ATOM   1226 C C   . ALA A 1 169 ? 19.196  -45.730 4.400   1.00 94.56  ? 181 ALA A C   1 
ATOM   1227 O O   . ALA A 1 169 ? 19.613  -46.494 5.294   1.00 95.48  ? 181 ALA A O   1 
ATOM   1228 C CB  . ALA A 1 169 ? 16.897  -45.751 3.404   1.00 94.36  ? 181 ALA A CB  1 
ATOM   1229 N N   . PHE A 1 170 ? 19.925  -45.322 3.358   1.00 91.12  ? 182 PHE A N   1 
ATOM   1230 C CA  . PHE A 1 170 ? 21.315  -45.753 3.271   1.00 97.64  ? 182 PHE A CA  1 
ATOM   1231 C C   . PHE A 1 170 ? 22.012  -45.567 4.613   1.00 103.36 ? 182 PHE A C   1 
ATOM   1232 O O   . PHE A 1 170 ? 22.672  -46.490 5.101   1.00 101.21 ? 182 PHE A O   1 
ATOM   1233 C CB  . PHE A 1 170 ? 22.054  -44.999 2.160   1.00 92.43  ? 182 PHE A CB  1 
ATOM   1234 C CG  . PHE A 1 170 ? 23.355  -45.642 1.752   1.00 87.54  ? 182 PHE A CG  1 
ATOM   1235 C CD1 . PHE A 1 170 ? 23.757  -46.838 2.291   1.00 84.91  ? 182 PHE A CD1 1 
ATOM   1236 C CD2 . PHE A 1 170 ? 24.168  -45.045 0.817   1.00 93.00  ? 182 PHE A CD2 1 
ATOM   1237 C CE1 . PHE A 1 170 ? 24.947  -47.417 1.910   1.00 93.54  ? 182 PHE A CE1 1 
ATOM   1238 C CE2 . PHE A 1 170 ? 25.356  -45.625 0.426   1.00 88.72  ? 182 PHE A CE2 1 
ATOM   1239 C CZ  . PHE A 1 170 ? 25.745  -46.812 0.970   1.00 89.11  ? 182 PHE A CZ  1 
ATOM   1240 N N   . LYS A 1 171 ? 21.810  -44.404 5.260   1.00 108.02 ? 183 LYS A N   1 
ATOM   1241 C CA  . LYS A 1 171 ? 22.481  -44.113 6.528   1.00 105.36 ? 183 LYS A CA  1 
ATOM   1242 C C   . LYS A 1 171 ? 22.025  -45.038 7.654   1.00 102.68 ? 183 LYS A C   1 
ATOM   1243 O O   . LYS A 1 171 ? 22.851  -45.488 8.451   1.00 108.31 ? 183 LYS A O   1 
ATOM   1244 C CB  . LYS A 1 171 ? 22.274  -42.659 6.984   1.00 105.74 ? 183 LYS A CB  1 
ATOM   1245 C CG  . LYS A 1 171 ? 23.119  -41.527 6.381   1.00 92.17  ? 183 LYS A CG  1 
ATOM   1246 C CD  . LYS A 1 171 ? 22.214  -40.304 6.364   1.00 95.25  ? 183 LYS A CD  1 
ATOM   1247 C CE  . LYS A 1 171 ? 22.922  -39.002 6.607   1.00 95.28  ? 183 LYS A CE  1 
ATOM   1248 N NZ  . LYS A 1 171 ? 21.978  -38.207 7.429   1.00 96.39  ? 183 LYS A NZ  1 
ATOM   1249 N N   . ASN A 1 172 ? 20.721  -45.277 7.807   1.00 103.30 ? 184 ASN A N   1 
ATOM   1250 C CA  . ASN A 1 172 ? 20.344  -46.175 8.896   1.00 105.66 ? 184 ASN A CA  1 
ATOM   1251 C C   . ASN A 1 172 ? 20.781  -47.607 8.621   1.00 110.70 ? 184 ASN A C   1 
ATOM   1252 O O   . ASN A 1 172 ? 20.923  -48.390 9.566   1.00 112.02 ? 184 ASN A O   1 
ATOM   1253 C CB  . ASN A 1 172 ? 18.847  -46.138 9.171   1.00 96.04  ? 184 ASN A CB  1 
ATOM   1254 C CG  . ASN A 1 172 ? 18.300  -44.752 9.200   1.00 100.34 ? 184 ASN A CG  1 
ATOM   1255 O OD1 . ASN A 1 172 ? 18.938  -43.825 9.706   1.00 102.34 ? 184 ASN A OD1 1 
ATOM   1256 N ND2 . ASN A 1 172 ? 17.106  -44.587 8.651   1.00 105.64 ? 184 ASN A ND2 1 
ATOM   1257 N N   . PHE A 1 173 ? 21.040  -47.956 7.352   1.00 111.26 ? 185 PHE A N   1 
ATOM   1258 C CA  . PHE A 1 173 ? 21.328  -49.350 7.008   1.00 109.60 ? 185 PHE A CA  1 
ATOM   1259 C C   . PHE A 1 173 ? 22.783  -49.689 7.310   1.00 113.33 ? 185 PHE A C   1 
ATOM   1260 O O   . PHE A 1 173 ? 23.083  -50.795 7.779   1.00 124.34 ? 185 PHE A O   1 
ATOM   1261 C CB  . PHE A 1 173 ? 20.971  -49.603 5.531   1.00 110.17 ? 185 PHE A CB  1 
ATOM   1262 C CG  . PHE A 1 173 ? 21.767  -50.704 4.845   1.00 110.43 ? 185 PHE A CG  1 
ATOM   1263 C CD1 . PHE A 1 173 ? 21.446  -52.043 5.044   1.00 100.12 ? 185 PHE A CD1 1 
ATOM   1264 C CD2 . PHE A 1 173 ? 22.791  -50.395 3.943   1.00 114.36 ? 185 PHE A CD2 1 
ATOM   1265 C CE1 . PHE A 1 173 ? 22.153  -53.054 4.388   1.00 103.57 ? 185 PHE A CE1 1 
ATOM   1266 C CE2 . PHE A 1 173 ? 23.508  -51.405 3.288   1.00 108.64 ? 185 PHE A CE2 1 
ATOM   1267 C CZ  . PHE A 1 173 ? 23.186  -52.733 3.512   1.00 105.09 ? 185 PHE A CZ  1 
ATOM   1268 N N   . LYS A 1 174 ? 23.696  -48.740 7.089   1.00 109.53 ? 186 LYS A N   1 
ATOM   1269 C CA  . LYS A 1 174 ? 25.109  -48.925 7.383   1.00 104.74 ? 186 LYS A CA  1 
ATOM   1270 C C   . LYS A 1 174 ? 25.521  -48.234 8.687   1.00 109.10 ? 186 LYS A C   1 
ATOM   1271 O O   . LYS A 1 174 ? 26.715  -47.980 8.882   1.00 112.04 ? 186 LYS A O   1 
ATOM   1272 C CB  . LYS A 1 174 ? 25.962  -48.398 6.218   1.00 101.41 ? 186 LYS A CB  1 
ATOM   1273 C CG  . LYS A 1 174 ? 26.233  -49.357 5.024   1.00 97.07  ? 186 LYS A CG  1 
ATOM   1274 C CD  . LYS A 1 174 ? 26.744  -50.757 5.363   1.00 103.49 ? 186 LYS A CD  1 
ATOM   1275 C CE  . LYS A 1 174 ? 27.771  -50.796 6.484   1.00 105.73 ? 186 LYS A CE  1 
ATOM   1276 N NZ  . LYS A 1 174 ? 28.455  -52.111 6.568   1.00 106.48 ? 186 LYS A NZ  1 
ATOM   1277 N N   . ASN A 1 175 ? 24.562  -47.930 9.583   1.00 110.42 ? 187 ASN A N   1 
ATOM   1278 C CA  . ASN A 1 175 ? 24.779  -47.093 10.773  1.00 111.62 ? 187 ASN A CA  1 
ATOM   1279 C C   . ASN A 1 175 ? 25.823  -45.986 10.573  1.00 112.47 ? 187 ASN A C   1 
ATOM   1280 O O   . ASN A 1 175 ? 26.733  -45.854 11.394  1.00 119.89 ? 187 ASN A O   1 
ATOM   1281 C CB  . ASN A 1 175 ? 25.165  -47.964 11.990  1.00 116.11 ? 187 ASN A CB  1 
ATOM   1282 C CG  . ASN A 1 175 ? 24.568  -47.447 13.313  1.00 118.27 ? 187 ASN A CG  1 
ATOM   1283 O OD1 . ASN A 1 175 ? 23.548  -46.755 13.313  1.00 119.89 ? 187 ASN A OD1 1 
ATOM   1284 N ND2 . ASN A 1 175 ? 25.247  -47.739 14.442  1.00 109.85 ? 187 ASN A ND2 1 
ATOM   1285 N N   . LEU A 1 176 ? 25.694  -45.176 9.504   1.00 109.93 ? 188 LEU A N   1 
ATOM   1286 C CA  . LEU A 1 176 ? 26.659  -44.105 9.171   1.00 106.08 ? 188 LEU A CA  1 
ATOM   1287 C C   . LEU A 1 176 ? 26.476  -42.869 10.084  1.00 98.88  ? 188 LEU A C   1 
ATOM   1288 O O   . LEU A 1 176 ? 25.538  -42.802 10.883  1.00 95.01  ? 188 LEU A O   1 
ATOM   1289 C CB  . LEU A 1 176 ? 26.549  -43.756 7.675   1.00 100.90 ? 188 LEU A CB  1 
ATOM   1290 C CG  . LEU A 1 176 ? 27.080  -44.692 6.561   1.00 99.31  ? 188 LEU A CG  1 
ATOM   1291 C CD1 . LEU A 1 176 ? 26.707  -44.214 5.174   1.00 99.81  ? 188 LEU A CD1 1 
ATOM   1292 C CD2 . LEU A 1 176 ? 28.588  -44.854 6.585   1.00 103.56 ? 188 LEU A CD2 1 
ATOM   1293 N N   . PRO A 1 177 ? 27.390  -41.889 10.032  1.00 96.24  ? 189 PRO A N   1 
ATOM   1294 C CA  . PRO A 1 177 ? 27.245  -40.716 10.907  1.00 99.65  ? 189 PRO A CA  1 
ATOM   1295 C C   . PRO A 1 177 ? 26.286  -39.712 10.285  1.00 107.30 ? 189 PRO A C   1 
ATOM   1296 O O   . PRO A 1 177 ? 26.495  -39.298 9.139   1.00 104.86 ? 189 PRO A O   1 
ATOM   1297 C CB  . PRO A 1 177 ? 28.660  -40.128 10.943  1.00 105.61 ? 189 PRO A CB  1 
ATOM   1298 C CG  . PRO A 1 177 ? 29.567  -41.195 10.450  1.00 100.55 ? 189 PRO A CG  1 
ATOM   1299 C CD  . PRO A 1 177 ? 28.746  -41.932 9.444   1.00 97.11  ? 189 PRO A CD  1 
ATOM   1300 N N   . GLU A 1 178 ? 25.264  -39.274 11.050  1.00 101.49 ? 190 GLU A N   1 
ATOM   1301 C CA  . GLU A 1 178 ? 24.344  -38.261 10.519  1.00 103.73 ? 190 GLU A CA  1 
ATOM   1302 C C   . GLU A 1 178 ? 25.072  -37.099 9.852   1.00 108.76 ? 190 GLU A C   1 
ATOM   1303 O O   . GLU A 1 178 ? 24.592  -36.562 8.843   1.00 103.91 ? 190 GLU A O   1 
ATOM   1304 C CB  . GLU A 1 178 ? 23.398  -37.744 11.602  1.00 101.38 ? 190 GLU A CB  1 
ATOM   1305 C CG  . GLU A 1 178 ? 22.658  -38.800 12.395  1.00 117.02 ? 190 GLU A CG  1 
ATOM   1306 C CD  . GLU A 1 178 ? 21.383  -39.260 11.662  1.00 129.66 ? 190 GLU A CD  1 
ATOM   1307 O OE1 . GLU A 1 178 ? 21.123  -38.738 10.545  1.00 121.79 ? 190 GLU A OE1 1 
ATOM   1308 O OE2 . GLU A 1 178 ? 20.655  -40.143 12.190  1.00 127.62 ? 190 GLU A OE2 1 
ATOM   1309 N N   . ASP A 1 179 ? 26.248  -36.729 10.366  1.00 110.02 ? 191 ASP A N   1 
ATOM   1310 C CA  . ASP A 1 179 ? 27.063  -35.692 9.751   1.00 105.25 ? 191 ASP A CA  1 
ATOM   1311 C C   . ASP A 1 179 ? 27.740  -36.151 8.474   1.00 105.02 ? 191 ASP A C   1 
ATOM   1312 O O   . ASP A 1 179 ? 28.505  -35.357 7.906   1.00 110.85 ? 191 ASP A O   1 
ATOM   1313 C CB  . ASP A 1 179 ? 28.143  -35.200 10.723  1.00 108.48 ? 191 ASP A CB  1 
ATOM   1314 C CG  . ASP A 1 179 ? 28.851  -36.343 11.446  1.00 119.82 ? 191 ASP A CG  1 
ATOM   1315 O OD1 . ASP A 1 179 ? 28.297  -36.830 12.455  1.00 122.50 ? 191 ASP A OD1 1 
ATOM   1316 O OD2 . ASP A 1 179 ? 29.953  -36.766 11.003  1.00 126.68 ? 191 ASP A OD2 1 
ATOM   1317 N N   . ILE A 1 180 ? 27.512  -37.385 8.009   1.00 99.78  ? 192 ILE A N   1 
ATOM   1318 C CA  . ILE A 1 180 ? 28.236  -37.826 6.827   1.00 100.59 ? 192 ILE A CA  1 
ATOM   1319 C C   . ILE A 1 180 ? 27.923  -36.905 5.661   1.00 92.15  ? 192 ILE A C   1 
ATOM   1320 O O   . ILE A 1 180 ? 26.770  -36.507 5.427   1.00 84.44  ? 192 ILE A O   1 
ATOM   1321 C CB  . ILE A 1 180 ? 27.975  -39.306 6.498   1.00 94.07  ? 192 ILE A CB  1 
ATOM   1322 C CG1 . ILE A 1 180 ? 29.070  -39.772 5.528   1.00 85.54  ? 192 ILE A CG1 1 
ATOM   1323 C CG2 . ILE A 1 180 ? 26.545  -39.546 6.007   1.00 91.07  ? 192 ILE A CG2 1 
ATOM   1324 C CD1 . ILE A 1 180 ? 28.933  -41.152 5.004   1.00 85.65  ? 192 ILE A CD1 1 
ATOM   1325 N N   . GLY A 1 181 ? 28.981  -36.509 4.963   1.00 85.36  ? 193 GLY A N   1 
ATOM   1326 C CA  . GLY A 1 181 ? 28.851  -35.550 3.901   1.00 88.23  ? 193 GLY A CA  1 
ATOM   1327 C C   . GLY A 1 181 ? 28.533  -36.247 2.610   1.00 89.19  ? 193 GLY A C   1 
ATOM   1328 O O   . GLY A 1 181 ? 29.261  -37.147 2.184   1.00 90.46  ? 193 GLY A O   1 
ATOM   1329 N N   . VAL A 1 182 ? 27.445  -35.822 1.971   1.00 87.69  ? 194 VAL A N   1 
ATOM   1330 C CA  . VAL A 1 182 ? 26.865  -36.501 0.821   1.00 84.13  ? 194 VAL A CA  1 
ATOM   1331 C C   . VAL A 1 182 ? 27.233  -35.752 -0.454  1.00 83.83  ? 194 VAL A C   1 
ATOM   1332 O O   . VAL A 1 182 ? 27.466  -34.538 -0.431  1.00 82.85  ? 194 VAL A O   1 
ATOM   1333 C CB  . VAL A 1 182 ? 25.342  -36.588 1.024   1.00 80.82  ? 194 VAL A CB  1 
ATOM   1334 C CG1 . VAL A 1 182 ? 24.668  -37.207 -0.166  1.00 80.97  ? 194 VAL A CG1 1 
ATOM   1335 C CG2 . VAL A 1 182 ? 25.055  -37.350 2.288   1.00 84.07  ? 194 VAL A CG2 1 
ATOM   1336 N N   . GLY A 1 183 ? 27.297  -36.487 -1.569  1.00 85.46  ? 195 GLY A N   1 
ATOM   1337 C CA  . GLY A 1 183 ? 27.689  -35.926 -2.853  1.00 85.03  ? 195 GLY A CA  1 
ATOM   1338 C C   . GLY A 1 183 ? 26.888  -36.334 -4.084  1.00 82.02  ? 195 GLY A C   1 
ATOM   1339 O O   . GLY A 1 183 ? 27.136  -37.372 -4.699  1.00 84.78  ? 195 GLY A O   1 
ATOM   1340 N N   . PHE A 1 184 ? 25.958  -35.480 -4.485  1.00 75.13  ? 196 PHE A N   1 
ATOM   1341 C CA  . PHE A 1 184 ? 25.001  -35.751 -5.545  1.00 71.70  ? 196 PHE A CA  1 
ATOM   1342 C C   . PHE A 1 184 ? 25.624  -35.697 -6.931  1.00 72.74  ? 196 PHE A C   1 
ATOM   1343 O O   . PHE A 1 184 ? 26.545  -34.930 -7.186  1.00 75.99  ? 196 PHE A O   1 
ATOM   1344 C CB  . PHE A 1 184 ? 23.879  -34.742 -5.436  1.00 66.03  ? 196 PHE A CB  1 
ATOM   1345 C CG  . PHE A 1 184 ? 23.030  -34.956 -4.258  1.00 62.47  ? 196 PHE A CG  1 
ATOM   1346 C CD1 . PHE A 1 184 ? 23.476  -34.625 -3.017  1.00 63.01  ? 196 PHE A CD1 1 
ATOM   1347 C CD2 . PHE A 1 184 ? 21.742  -35.395 -4.403  1.00 70.18  ? 196 PHE A CD2 1 
ATOM   1348 C CE1 . PHE A 1 184 ? 22.697  -34.820 -1.930  1.00 68.31  ? 196 PHE A CE1 1 
ATOM   1349 C CE2 . PHE A 1 184 ? 20.943  -35.574 -3.311  1.00 68.93  ? 196 PHE A CE2 1 
ATOM   1350 C CZ  . PHE A 1 184 ? 21.421  -35.290 -2.074  1.00 65.67  ? 196 PHE A CZ  1 
ATOM   1351 N N   . TYR A 1 185 ? 25.084  -36.510 -7.835  1.00 72.44  ? 197 TYR A N   1 
ATOM   1352 C CA  . TYR A 1 185 ? 25.458  -36.510 -9.243  1.00 79.63  ? 197 TYR A CA  1 
ATOM   1353 C C   . TYR A 1 185 ? 24.260  -36.883 -10.120 1.00 82.33  ? 197 TYR A C   1 
ATOM   1354 O O   . TYR A 1 185 ? 23.365  -37.625 -9.702  1.00 78.54  ? 197 TYR A O   1 
ATOM   1355 C CB  . TYR A 1 185 ? 26.608  -37.467 -9.536  1.00 69.45  ? 197 TYR A CB  1 
ATOM   1356 C CG  . TYR A 1 185 ? 27.246  -37.241 -10.886 1.00 71.18  ? 197 TYR A CG  1 
ATOM   1357 C CD1 . TYR A 1 185 ? 28.280  -36.357 -11.063 1.00 79.76  ? 197 TYR A CD1 1 
ATOM   1358 C CD2 . TYR A 1 185 ? 26.789  -37.911 -11.994 1.00 75.54  ? 197 TYR A CD2 1 
ATOM   1359 C CE1 . TYR A 1 185 ? 28.864  -36.170 -12.323 1.00 80.68  ? 197 TYR A CE1 1 
ATOM   1360 C CE2 . TYR A 1 185 ? 27.358  -37.726 -13.247 1.00 79.08  ? 197 TYR A CE2 1 
ATOM   1361 C CZ  . TYR A 1 185 ? 28.393  -36.863 -13.413 1.00 75.51  ? 197 TYR A CZ  1 
ATOM   1362 O OH  . TYR A 1 185 ? 28.932  -36.721 -14.678 1.00 67.31  ? 197 TYR A OH  1 
ATOM   1363 N N   . GLY A 1 186 ? 24.256  -36.355 -11.344 1.00 80.69  ? 198 GLY A N   1 
ATOM   1364 C CA  . GLY A 1 186 ? 23.182  -36.624 -12.288 1.00 79.91  ? 198 GLY A CA  1 
ATOM   1365 C C   . GLY A 1 186 ? 23.440  -35.973 -13.634 1.00 81.37  ? 198 GLY A C   1 
ATOM   1366 O O   . GLY A 1 186 ? 24.243  -35.045 -13.760 1.00 81.67  ? 198 GLY A O   1 
ATOM   1367 N N   . TYR A 1 187 ? 22.749  -36.499 -14.649 1.00 88.14  ? 199 TYR A N   1 
ATOM   1368 C CA  . TYR A 1 187 ? 22.686  -35.871 -15.965 1.00 81.13  ? 199 TYR A CA  1 
ATOM   1369 C C   . TYR A 1 187 ? 21.339  -36.225 -16.584 1.00 85.64  ? 199 TYR A C   1 
ATOM   1370 O O   . TYR A 1 187 ? 20.679  -37.193 -16.178 1.00 83.36  ? 199 TYR A O   1 
ATOM   1371 C CB  . TYR A 1 187 ? 23.871  -36.284 -16.853 1.00 70.48  ? 199 TYR A CB  1 
ATOM   1372 C CG  . TYR A 1 187 ? 24.062  -35.466 -18.110 1.00 71.77  ? 199 TYR A CG  1 
ATOM   1373 C CD1 . TYR A 1 187 ? 24.753  -34.276 -18.080 1.00 78.82  ? 199 TYR A CD1 1 
ATOM   1374 C CD2 . TYR A 1 187 ? 23.649  -35.927 -19.333 1.00 73.59  ? 199 TYR A CD2 1 
ATOM   1375 C CE1 . TYR A 1 187 ? 24.951  -33.518 -19.236 1.00 83.32  ? 199 TYR A CE1 1 
ATOM   1376 C CE2 . TYR A 1 187 ? 23.856  -35.189 -20.501 1.00 76.35  ? 199 TYR A CE2 1 
ATOM   1377 C CZ  . TYR A 1 187 ? 24.509  -33.984 -20.449 1.00 80.01  ? 199 TYR A CZ  1 
ATOM   1378 O OH  . TYR A 1 187 ? 24.717  -33.232 -21.593 1.00 78.29  ? 199 TYR A OH  1 
ATOM   1379 N N   . SER A 1 188 ? 20.926  -35.395 -17.550 1.00 85.43  ? 200 SER A N   1 
ATOM   1380 C CA  . SER A 1 188 ? 19.594  -35.419 -18.149 1.00 77.49  ? 200 SER A CA  1 
ATOM   1381 C C   . SER A 1 188 ? 18.558  -35.664 -17.052 1.00 79.48  ? 200 SER A C   1 
ATOM   1382 O O   . SER A 1 188 ? 18.447  -34.868 -16.109 1.00 77.66  ? 200 SER A O   1 
ATOM   1383 C CB  . SER A 1 188 ? 19.533  -36.462 -19.273 1.00 75.51  ? 200 SER A CB  1 
ATOM   1384 O OG  . SER A 1 188 ? 18.355  -36.344 -20.051 1.00 81.12  ? 200 SER A OG  1 
ATOM   1385 N N   . GLY A 1 189 ? 17.824  -36.773 -17.133 1.00 79.42  ? 201 GLY A N   1 
ATOM   1386 C CA  . GLY A 1 189 ? 16.771  -36.998 -16.161 1.00 78.61  ? 201 GLY A CA  1 
ATOM   1387 C C   . GLY A 1 189 ? 17.278  -37.201 -14.760 1.00 77.16  ? 201 GLY A C   1 
ATOM   1388 O O   . GLY A 1 189 ? 16.521  -36.997 -13.800 1.00 74.57  ? 201 GLY A O   1 
ATOM   1389 N N   . GLY A 1 190 ? 18.537  -37.625 -14.628 1.00 74.95  ? 202 GLY A N   1 
ATOM   1390 C CA  . GLY A 1 190 ? 19.148  -37.718 -13.313 1.00 78.95  ? 202 GLY A CA  1 
ATOM   1391 C C   . GLY A 1 190 ? 19.503  -36.357 -12.746 1.00 78.18  ? 202 GLY A C   1 
ATOM   1392 O O   . GLY A 1 190 ? 19.335  -36.105 -11.546 1.00 75.23  ? 202 GLY A O   1 
ATOM   1393 N N   . ALA A 1 191 ? 19.996  -35.460 -13.603 1.00 75.22  ? 203 ALA A N   1 
ATOM   1394 C CA  . ALA A 1 191 ? 20.145  -34.066 -13.211 1.00 75.03  ? 203 ALA A CA  1 
ATOM   1395 C C   . ALA A 1 191 ? 18.820  -33.503 -12.728 1.00 70.12  ? 203 ALA A C   1 
ATOM   1396 O O   . ALA A 1 191 ? 18.754  -32.872 -11.671 1.00 73.18  ? 203 ALA A O   1 
ATOM   1397 C CB  . ALA A 1 191 ? 20.693  -33.244 -14.376 1.00 74.85  ? 203 ALA A CB  1 
ATOM   1398 N N   . HIS A 1 192 ? 17.748  -33.737 -13.483 1.00 67.07  ? 204 HIS A N   1 
ATOM   1399 C CA  . HIS A 1 192 ? 16.437  -33.290 -13.037 1.00 71.99  ? 204 HIS A CA  1 
ATOM   1400 C C   . HIS A 1 192 ? 16.090  -33.874 -11.676 1.00 69.87  ? 204 HIS A C   1 
ATOM   1401 O O   . HIS A 1 192 ? 15.580  -33.168 -10.801 1.00 67.30  ? 204 HIS A O   1 
ATOM   1402 C CB  . HIS A 1 192 ? 15.366  -33.668 -14.058 1.00 79.37  ? 204 HIS A CB  1 
ATOM   1403 C CG  . HIS A 1 192 ? 13.974  -33.362 -13.602 1.00 73.70  ? 204 HIS A CG  1 
ATOM   1404 N ND1 . HIS A 1 192 ? 13.347  -34.072 -12.602 1.00 72.73  ? 204 HIS A ND1 1 
ATOM   1405 C CD2 . HIS A 1 192 ? 13.086  -32.434 -14.014 1.00 69.15  ? 204 HIS A CD2 1 
ATOM   1406 C CE1 . HIS A 1 192 ? 12.140  -33.583 -12.399 1.00 69.13  ? 204 HIS A CE1 1 
ATOM   1407 N NE2 . HIS A 1 192 ? 11.953  -32.592 -13.247 1.00 73.53  ? 204 HIS A NE2 1 
ATOM   1408 N N   . ALA A 1 193 ? 16.333  -35.166 -11.486 1.00 70.92  ? 205 ALA A N   1 
ATOM   1409 C CA  . ALA A 1 193 ? 16.016  -35.781 -10.205 1.00 73.20  ? 205 ALA A CA  1 
ATOM   1410 C C   . ALA A 1 193 ? 16.909  -35.244 -9.106  1.00 73.94  ? 205 ALA A C   1 
ATOM   1411 O O   . ALA A 1 193 ? 16.452  -35.034 -7.975  1.00 74.09  ? 205 ALA A O   1 
ATOM   1412 C CB  . ALA A 1 193 ? 16.154  -37.292 -10.306 1.00 79.01  ? 205 ALA A CB  1 
ATOM   1413 N N   . THR A 1 194 ? 18.188  -35.036 -9.424  1.00 72.73  ? 206 THR A N   1 
ATOM   1414 C CA  . THR A 1 194 ? 19.145  -34.380 -8.545  1.00 74.84  ? 206 THR A CA  1 
ATOM   1415 C C   . THR A 1 194 ? 18.684  -32.975 -8.192  1.00 78.17  ? 206 THR A C   1 
ATOM   1416 O O   . THR A 1 194 ? 18.306  -32.708 -7.044  1.00 76.25  ? 206 THR A O   1 
ATOM   1417 C CB  . THR A 1 194 ? 20.505  -34.288 -9.216  1.00 76.09  ? 206 THR A CB  1 
ATOM   1418 O OG1 . THR A 1 194 ? 20.992  -35.604 -9.491  1.00 85.02  ? 206 THR A OG1 1 
ATOM   1419 C CG2 . THR A 1 194 ? 21.474  -33.567 -8.312  1.00 71.68  ? 206 THR A CG2 1 
ATOM   1420 N N   . ALA A 1 195 ? 18.716  -32.082 -9.194  1.00 75.80  ? 207 ALA A N   1 
ATOM   1421 C CA  . ALA A 1 195 ? 18.259  -30.703 -9.088  1.00 72.41  ? 207 ALA A CA  1 
ATOM   1422 C C   . ALA A 1 195 ? 17.047  -30.572 -8.187  1.00 71.59  ? 207 ALA A C   1 
ATOM   1423 O O   . ALA A 1 195 ? 16.930  -29.588 -7.461  1.00 81.74  ? 207 ALA A O   1 
ATOM   1424 C CB  . ALA A 1 195 ? 17.930  -30.135 -10.464 1.00 68.67  ? 207 ALA A CB  1 
ATOM   1425 N N   . TRP A 1 196 ? 16.147  -31.552 -8.207  1.00 68.38  ? 208 TRP A N   1 
ATOM   1426 C CA  . TRP A 1 196 ? 14.997  -31.475 -7.315  1.00 74.65  ? 208 TRP A CA  1 
ATOM   1427 C C   . TRP A 1 196 ? 15.333  -31.975 -5.914  1.00 78.80  ? 208 TRP A C   1 
ATOM   1428 O O   . TRP A 1 196 ? 14.762  -31.483 -4.930  1.00 75.84  ? 208 TRP A O   1 
ATOM   1429 C CB  . TRP A 1 196 ? 13.819  -32.258 -7.904  1.00 71.15  ? 208 TRP A CB  1 
ATOM   1430 C CG  . TRP A 1 196 ? 12.926  -31.388 -8.755  1.00 69.93  ? 208 TRP A CG  1 
ATOM   1431 C CD1 . TRP A 1 196 ? 12.978  -31.244 -10.113 1.00 70.68  ? 208 TRP A CD1 1 
ATOM   1432 C CD2 . TRP A 1 196 ? 11.892  -30.513 -8.305  1.00 66.27  ? 208 TRP A CD2 1 
ATOM   1433 N NE1 . TRP A 1 196 ? 12.020  -30.354 -10.535 1.00 66.64  ? 208 TRP A NE1 1 
ATOM   1434 C CE2 . TRP A 1 196 ? 11.344  -29.893 -9.441  1.00 66.20  ? 208 TRP A CE2 1 
ATOM   1435 C CE3 . TRP A 1 196 ? 11.373  -30.203 -7.055  1.00 69.77  ? 208 TRP A CE3 1 
ATOM   1436 C CZ2 . TRP A 1 196 ? 10.312  -29.000 -9.363  1.00 69.87  ? 208 TRP A CZ2 1 
ATOM   1437 C CZ3 . TRP A 1 196 ? 10.360  -29.315 -6.980  1.00 71.19  ? 208 TRP A CZ3 1 
ATOM   1438 C CH2 . TRP A 1 196 ? 9.828   -28.722 -8.125  1.00 73.52  ? 208 TRP A CH2 1 
ATOM   1439 N N   . ALA A 1 197 ? 16.271  -32.922 -5.796  1.00 81.13  ? 209 ALA A N   1 
ATOM   1440 C CA  . ALA A 1 197 ? 16.592  -33.467 -4.481  1.00 79.45  ? 209 ALA A CA  1 
ATOM   1441 C C   . ALA A 1 197 ? 17.339  -32.447 -3.634  1.00 82.96  ? 209 ALA A C   1 
ATOM   1442 O O   . ALA A 1 197 ? 17.098  -32.350 -2.425  1.00 83.46  ? 209 ALA A O   1 
ATOM   1443 C CB  . ALA A 1 197 ? 17.395  -34.751 -4.628  1.00 75.34  ? 209 ALA A CB  1 
ATOM   1444 N N   . VAL A 1 198 ? 18.236  -31.668 -4.255  1.00 79.69  ? 210 VAL A N   1 
ATOM   1445 C CA  . VAL A 1 198 ? 18.874  -30.548 -3.562  1.00 74.77  ? 210 VAL A CA  1 
ATOM   1446 C C   . VAL A 1 198 ? 17.837  -29.481 -3.197  1.00 76.18  ? 210 VAL A C   1 
ATOM   1447 O O   . VAL A 1 198 ? 17.703  -29.102 -2.029  1.00 77.98  ? 210 VAL A O   1 
ATOM   1448 C CB  . VAL A 1 198 ? 20.043  -29.976 -4.399  1.00 72.47  ? 210 VAL A CB  1 
ATOM   1449 C CG1 . VAL A 1 198 ? 21.127  -31.009 -4.620  1.00 70.06  ? 210 VAL A CG1 1 
ATOM   1450 C CG2 . VAL A 1 198 ? 19.594  -29.452 -5.768  1.00 78.47  ? 210 VAL A CG2 1 
ATOM   1451 N N   . SER A 1 199 ? 17.068  -29.003 -4.182  1.00 74.39  ? 211 SER A N   1 
ATOM   1452 C CA  . SER A 1 199 ? 16.056  -27.981 -3.921  1.00 79.51  ? 211 SER A CA  1 
ATOM   1453 C C   . SER A 1 199 ? 15.204  -28.342 -2.720  1.00 81.91  ? 211 SER A C   1 
ATOM   1454 O O   . SER A 1 199 ? 14.893  -27.490 -1.881  1.00 77.38  ? 211 SER A O   1 
ATOM   1455 C CB  . SER A 1 199 ? 15.166  -27.788 -5.152  1.00 77.58  ? 211 SER A CB  1 
ATOM   1456 O OG  . SER A 1 199 ? 14.564  -26.504 -5.178  1.00 77.56  ? 211 SER A OG  1 
ATOM   1457 N N   . LEU A 1 200 ? 14.835  -29.609 -2.611  1.00 84.08  ? 212 LEU A N   1 
ATOM   1458 C CA  . LEU A 1 200 ? 14.010  -30.040 -1.500  1.00 91.56  ? 212 LEU A CA  1 
ATOM   1459 C C   . LEU A 1 200 ? 14.826  -30.324 -0.252  1.00 91.91  ? 212 LEU A C   1 
ATOM   1460 O O   . LEU A 1 200 ? 14.280  -30.242 0.854   1.00 90.06  ? 212 LEU A O   1 
ATOM   1461 C CB  . LEU A 1 200 ? 13.229  -31.285 -1.907  1.00 85.56  ? 212 LEU A CB  1 
ATOM   1462 C CG  . LEU A 1 200 ? 12.121  -30.898 -2.877  1.00 80.16  ? 212 LEU A CG  1 
ATOM   1463 C CD1 . LEU A 1 200 ? 11.287  -32.113 -3.250  1.00 79.85  ? 212 LEU A CD1 1 
ATOM   1464 C CD2 . LEU A 1 200 ? 11.273  -29.784 -2.274  1.00 80.46  ? 212 LEU A CD2 1 
ATOM   1465 N N   . ALA A 1 201 ? 16.125  -30.604 -0.416  1.00 87.11  ? 213 ALA A N   1 
ATOM   1466 C CA  . ALA A 1 201 ? 16.924  -31.209 0.646   1.00 89.19  ? 213 ALA A CA  1 
ATOM   1467 C C   . ALA A 1 201 ? 16.822  -30.436 1.946   1.00 97.06  ? 213 ALA A C   1 
ATOM   1468 O O   . ALA A 1 201 ? 16.699  -31.025 3.025   1.00 96.35  ? 213 ALA A O   1 
ATOM   1469 C CB  . ALA A 1 201 ? 18.384  -31.305 0.210   1.00 87.00  ? 213 ALA A CB  1 
ATOM   1470 N N   . GLU A 1 202 ? 16.878  -29.112 1.865   1.00 104.64 ? 214 GLU A N   1 
ATOM   1471 C CA  . GLU A 1 202 ? 16.862  -28.318 3.083   1.00 107.23 ? 214 GLU A CA  1 
ATOM   1472 C C   . GLU A 1 202 ? 15.532  -28.477 3.794   1.00 96.78  ? 214 GLU A C   1 
ATOM   1473 O O   . GLU A 1 202 ? 15.486  -28.719 5.003   1.00 97.10  ? 214 GLU A O   1 
ATOM   1474 C CB  . GLU A 1 202 ? 17.140  -26.852 2.750   1.00 116.17 ? 214 GLU A CB  1 
ATOM   1475 C CG  . GLU A 1 202 ? 17.257  -25.917 3.957   1.00 117.82 ? 214 GLU A CG  1 
ATOM   1476 C CD  . GLU A 1 202 ? 17.703  -26.623 5.230   1.00 119.19 ? 214 GLU A CD  1 
ATOM   1477 O OE1 . GLU A 1 202 ? 18.843  -27.145 5.267   1.00 120.71 ? 214 GLU A OE1 1 
ATOM   1478 O OE2 . GLU A 1 202 ? 16.914  -26.643 6.201   1.00 122.34 ? 214 GLU A OE2 1 
ATOM   1479 N N   . GLY A 1 203 ? 14.437  -28.394 3.042   1.00 100.52 ? 215 GLY A N   1 
ATOM   1480 C CA  . GLY A 1 203 ? 13.126  -28.524 3.651   1.00 108.51 ? 215 GLY A CA  1 
ATOM   1481 C C   . GLY A 1 203 ? 12.846  -29.917 4.185   1.00 106.14 ? 215 GLY A C   1 
ATOM   1482 O O   . GLY A 1 203 ? 12.301  -30.070 5.283   1.00 103.37 ? 215 GLY A O   1 
ATOM   1483 N N   . TYR A 1 204 ? 13.212  -30.950 3.423   1.00 104.50 ? 216 TYR A N   1 
ATOM   1484 C CA  . TYR A 1 204 ? 12.777  -32.297 3.759   1.00 96.83  ? 216 TYR A CA  1 
ATOM   1485 C C   . TYR A 1 204 ? 13.790  -32.978 4.666   1.00 94.58  ? 216 TYR A C   1 
ATOM   1486 O O   . TYR A 1 204 ? 13.443  -33.388 5.776   1.00 94.65  ? 216 TYR A O   1 
ATOM   1487 C CB  . TYR A 1 204 ? 12.538  -33.094 2.470   1.00 93.24  ? 216 TYR A CB  1 
ATOM   1488 C CG  . TYR A 1 204 ? 11.868  -34.447 2.636   1.00 94.20  ? 216 TYR A CG  1 
ATOM   1489 C CD1 . TYR A 1 204 ? 10.554  -34.547 3.089   1.00 92.56  ? 216 TYR A CD1 1 
ATOM   1490 C CD2 . TYR A 1 204 ? 12.531  -35.623 2.293   1.00 97.87  ? 216 TYR A CD2 1 
ATOM   1491 C CE1 . TYR A 1 204 ? 9.933   -35.785 3.224   1.00 92.61  ? 216 TYR A CE1 1 
ATOM   1492 C CE2 . TYR A 1 204 ? 11.915  -36.863 2.426   1.00 94.43  ? 216 TYR A CE2 1 
ATOM   1493 C CZ  . TYR A 1 204 ? 10.625  -36.932 2.892   1.00 91.39  ? 216 TYR A CZ  1 
ATOM   1494 O OH  . TYR A 1 204 ? 10.042  -38.157 3.008   1.00 91.28  ? 216 TYR A OH  1 
ATOM   1495 N N   . ALA A 1 205 ? 15.053  -33.062 4.230   1.00 96.28  ? 217 ALA A N   1 
ATOM   1496 C CA  . ALA A 1 205 ? 16.117  -33.734 4.978   1.00 98.51  ? 217 ALA A CA  1 
ATOM   1497 C C   . ALA A 1 205 ? 17.189  -32.728 5.391   1.00 99.99  ? 217 ALA A C   1 
ATOM   1498 O O   . ALA A 1 205 ? 18.236  -32.602 4.736   1.00 101.85 ? 217 ALA A O   1 
ATOM   1499 C CB  . ALA A 1 205 ? 16.721  -34.875 4.162   1.00 93.70  ? 217 ALA A CB  1 
ATOM   1500 N N   . PRO A 1 206 ? 16.974  -32.000 6.484   1.00 96.27  ? 218 PRO A N   1 
ATOM   1501 C CA  . PRO A 1 206 ? 17.999  -31.046 6.908   1.00 99.17  ? 218 PRO A CA  1 
ATOM   1502 C C   . PRO A 1 206 ? 19.243  -31.734 7.433   1.00 103.25 ? 218 PRO A C   1 
ATOM   1503 O O   . PRO A 1 206 ? 20.344  -31.169 7.338   1.00 103.27 ? 218 PRO A O   1 
ATOM   1504 C CB  . PRO A 1 206 ? 17.297  -30.233 8.003   1.00 99.38  ? 218 PRO A CB  1 
ATOM   1505 C CG  . PRO A 1 206 ? 16.138  -31.039 8.410   1.00 91.56  ? 218 PRO A CG  1 
ATOM   1506 C CD  . PRO A 1 206 ? 15.752  -31.912 7.292   1.00 95.99  ? 218 PRO A CD  1 
ATOM   1507 N N   . GLU A 1 207 ? 19.104  -32.953 7.962   1.00 97.02  ? 219 GLU A N   1 
ATOM   1508 C CA  . GLU A 1 207 ? 20.203  -33.594 8.664   1.00 98.08  ? 219 GLU A CA  1 
ATOM   1509 C C   . GLU A 1 207 ? 21.196  -34.245 7.727   1.00 93.81  ? 219 GLU A C   1 
ATOM   1510 O O   . GLU A 1 207 ? 22.063  -35.003 8.173   1.00 100.65 ? 219 GLU A O   1 
ATOM   1511 C CB  . GLU A 1 207 ? 19.658  -34.604 9.678   1.00 101.71 ? 219 GLU A CB  1 
ATOM   1512 C CG  . GLU A 1 207 ? 19.457  -36.062 9.234   1.00 113.16 ? 219 GLU A CG  1 
ATOM   1513 C CD  . GLU A 1 207 ? 18.498  -36.221 8.070   1.00 110.72 ? 219 GLU A CD  1 
ATOM   1514 O OE1 . GLU A 1 207 ? 17.669  -35.293 7.864   1.00 107.40 ? 219 GLU A OE1 1 
ATOM   1515 O OE2 . GLU A 1 207 ? 18.534  -37.313 7.431   1.00 101.41 ? 219 GLU A OE2 1 
ATOM   1516 N N   . ILE A 1 208 ? 21.135  -33.928 6.457   1.00 86.13  ? 220 ILE A N   1 
ATOM   1517 C CA  . ILE A 1 208 ? 22.023  -34.528 5.491   1.00 89.34  ? 220 ILE A CA  1 
ATOM   1518 C C   . ILE A 1 208 ? 23.013  -33.453 5.082   1.00 86.43  ? 220 ILE A C   1 
ATOM   1519 O O   . ILE A 1 208 ? 22.697  -32.588 4.262   1.00 92.59  ? 220 ILE A O   1 
ATOM   1520 C CB  . ILE A 1 208 ? 21.244  -35.089 4.305   1.00 91.10  ? 220 ILE A CB  1 
ATOM   1521 C CG1 . ILE A 1 208 ? 20.088  -35.922 4.868   1.00 89.45  ? 220 ILE A CG1 1 
ATOM   1522 C CG2 . ILE A 1 208 ? 22.154  -35.905 3.404   1.00 84.22  ? 220 ILE A CG2 1 
ATOM   1523 C CD1 . ILE A 1 208 ? 19.542  -36.950 3.954   1.00 87.02  ? 220 ILE A CD1 1 
ATOM   1524 N N   . LYS A 1 209 ? 24.198  -33.472 5.682   1.00 85.86  ? 221 LYS A N   1 
ATOM   1525 C CA  . LYS A 1 209 ? 25.249  -32.581 5.219   1.00 89.87  ? 221 LYS A CA  1 
ATOM   1526 C C   . LYS A 1 209 ? 25.671  -32.939 3.809   1.00 84.54  ? 221 LYS A C   1 
ATOM   1527 O O   . LYS A 1 209 ? 25.819  -34.111 3.460   1.00 91.40  ? 221 LYS A O   1 
ATOM   1528 C CB  . LYS A 1 209 ? 26.458  -32.584 6.165   1.00 98.22  ? 221 LYS A CB  1 
ATOM   1529 C CG  . LYS A 1 209 ? 26.149  -32.578 7.661   1.00 103.27 ? 221 LYS A CG  1 
ATOM   1530 C CD  . LYS A 1 209 ? 25.343  -31.303 7.994   1.00 105.88 ? 221 LYS A CD  1 
ATOM   1531 C CE  . LYS A 1 209 ? 24.396  -31.475 9.164   1.00 98.96  ? 221 LYS A CE  1 
ATOM   1532 N NZ  . LYS A 1 209 ? 25.130  -32.011 10.337  1.00 107.97 ? 221 LYS A NZ  1 
ATOM   1533 N N   . ILE A 1 210 ? 25.853  -31.901 3.003   1.00 81.62  ? 222 ILE A N   1 
ATOM   1534 C CA  . ILE A 1 210 ? 26.147  -31.998 1.581   1.00 80.64  ? 222 ILE A CA  1 
ATOM   1535 C C   . ILE A 1 210 ? 27.416  -31.196 1.327   1.00 81.29  ? 222 ILE A C   1 
ATOM   1536 O O   . ILE A 1 210 ? 27.392  -29.965 1.344   1.00 84.84  ? 222 ILE A O   1 
ATOM   1537 C CB  . ILE A 1 210 ? 24.992  -31.471 0.733   1.00 78.58  ? 222 ILE A CB  1 
ATOM   1538 C CG1 . ILE A 1 210 ? 23.703  -32.195 1.130   1.00 83.09  ? 222 ILE A CG1 1 
ATOM   1539 C CG2 . ILE A 1 210 ? 25.327  -31.566 -0.726  1.00 75.55  ? 222 ILE A CG2 1 
ATOM   1540 C CD1 . ILE A 1 210 ? 22.449  -31.717 0.449   1.00 74.94  ? 222 ILE A CD1 1 
ATOM   1541 N N   . ASP A 1 211 ? 28.525  -31.881 1.091   1.00 79.81  ? 223 ASP A N   1 
ATOM   1542 C CA  . ASP A 1 211 ? 29.768  -31.195 0.761   1.00 83.87  ? 223 ASP A CA  1 
ATOM   1543 C C   . ASP A 1 211 ? 29.741  -30.573 -0.634  1.00 86.03  ? 223 ASP A C   1 
ATOM   1544 O O   . ASP A 1 211 ? 30.625  -29.761 -0.954  1.00 86.45  ? 223 ASP A O   1 
ATOM   1545 C CB  . ASP A 1 211 ? 30.938  -32.170 0.862   1.00 82.83  ? 223 ASP A CB  1 
ATOM   1546 C CG  . ASP A 1 211 ? 31.097  -32.743 2.254   1.00 87.85  ? 223 ASP A CG  1 
ATOM   1547 O OD1 . ASP A 1 211 ? 30.357  -32.302 3.174   1.00 84.84  ? 223 ASP A OD1 1 
ATOM   1548 O OD2 . ASP A 1 211 ? 31.934  -33.662 2.401   1.00 91.32  ? 223 ASP A OD2 1 
ATOM   1549 N N   . GLY A 1 212 ? 28.763  -30.932 -1.458  1.00 81.91  ? 224 GLY A N   1 
ATOM   1550 C CA  . GLY A 1 212 ? 28.672  -30.435 -2.818  1.00 78.50  ? 224 GLY A CA  1 
ATOM   1551 C C   . GLY A 1 212 ? 27.760  -31.316 -3.639  1.00 84.15  ? 224 GLY A C   1 
ATOM   1552 O O   . GLY A 1 212 ? 27.289  -32.359 -3.188  1.00 82.81  ? 224 GLY A O   1 
ATOM   1553 N N   . ALA A 1 213 ? 27.520  -30.879 -4.878  1.00 86.09  ? 225 ALA A N   1 
ATOM   1554 C CA  . ALA A 1 213 ? 26.706  -31.642 -5.825  1.00 77.47  ? 225 ALA A CA  1 
ATOM   1555 C C   . ALA A 1 213 ? 26.960  -31.142 -7.243  1.00 74.70  ? 225 ALA A C   1 
ATOM   1556 O O   . ALA A 1 213 ? 26.876  -29.942 -7.507  1.00 74.95  ? 225 ALA A O   1 
ATOM   1557 C CB  . ALA A 1 213 ? 25.222  -31.539 -5.480  1.00 69.97  ? 225 ALA A CB  1 
ATOM   1558 N N   . ALA A 1 214 ? 27.280  -32.060 -8.145  1.00 75.24  ? 226 ALA A N   1 
ATOM   1559 C CA  . ALA A 1 214 ? 27.455  -31.755 -9.556  1.00 78.30  ? 226 ALA A CA  1 
ATOM   1560 C C   . ALA A 1 214 ? 26.293  -32.336 -10.349 1.00 86.03  ? 226 ALA A C   1 
ATOM   1561 O O   . ALA A 1 214 ? 25.743  -33.373 -9.972  1.00 87.33  ? 226 ALA A O   1 
ATOM   1562 C CB  . ALA A 1 214 ? 28.771  -32.328 -10.076 1.00 79.40  ? 226 ALA A CB  1 
ATOM   1563 N N   . TYR A 1 215 ? 25.901  -31.654 -11.431 1.00 85.42  ? 227 TYR A N   1 
ATOM   1564 C CA  . TYR A 1 215 ? 24.876  -32.178 -12.334 1.00 81.23  ? 227 TYR A CA  1 
ATOM   1565 C C   . TYR A 1 215 ? 24.745  -31.301 -13.571 1.00 80.02  ? 227 TYR A C   1 
ATOM   1566 O O   . TYR A 1 215 ? 24.947  -30.095 -13.503 1.00 84.88  ? 227 TYR A O   1 
ATOM   1567 C CB  . TYR A 1 215 ? 23.519  -32.310 -11.659 1.00 71.85  ? 227 TYR A CB  1 
ATOM   1568 C CG  . TYR A 1 215 ? 22.986  -31.151 -10.860 1.00 78.78  ? 227 TYR A CG  1 
ATOM   1569 C CD1 . TYR A 1 215 ? 23.249  -31.015 -9.495  1.00 81.97  ? 227 TYR A CD1 1 
ATOM   1570 C CD2 . TYR A 1 215 ? 22.141  -30.224 -11.451 1.00 82.26  ? 227 TYR A CD2 1 
ATOM   1571 C CE1 . TYR A 1 215 ? 22.673  -29.960 -8.736  1.00 81.24  ? 227 TYR A CE1 1 
ATOM   1572 C CE2 . TYR A 1 215 ? 21.572  -29.174 -10.711 1.00 83.28  ? 227 TYR A CE2 1 
ATOM   1573 C CZ  . TYR A 1 215 ? 21.841  -29.041 -9.365  1.00 80.04  ? 227 TYR A CZ  1 
ATOM   1574 O OH  . TYR A 1 215 ? 21.249  -28.004 -8.677  1.00 70.72  ? 227 TYR A OH  1 
ATOM   1575 N N   . GLY A 1 216 ? 24.401  -31.925 -14.705 1.00 82.74  ? 228 GLY A N   1 
ATOM   1576 C CA  . GLY A 1 216 ? 24.396  -31.234 -15.984 1.00 81.81  ? 228 GLY A CA  1 
ATOM   1577 C C   . GLY A 1 216 ? 23.303  -31.655 -16.952 1.00 78.80  ? 228 GLY A C   1 
ATOM   1578 O O   . GLY A 1 216 ? 22.581  -32.633 -16.741 1.00 73.34  ? 228 GLY A O   1 
ATOM   1579 N N   . GLY A 1 217 ? 23.119  -30.878 -18.021 1.00 80.60  ? 229 GLY A N   1 
ATOM   1580 C CA  . GLY A 1 217 ? 21.977  -31.173 -18.909 1.00 79.91  ? 229 GLY A CA  1 
ATOM   1581 C C   . GLY A 1 217 ? 20.738  -31.274 -18.049 1.00 76.24  ? 229 GLY A C   1 
ATOM   1582 O O   . GLY A 1 217 ? 20.100  -32.341 -18.058 1.00 79.73  ? 229 GLY A O   1 
ATOM   1583 N N   . THR A 1 218 ? 20.365  -30.187 -17.372 1.00 73.80  ? 230 THR A N   1 
ATOM   1584 C CA  . THR A 1 218 ? 19.259  -30.255 -16.397 1.00 74.55  ? 230 THR A CA  1 
ATOM   1585 C C   . THR A 1 218 ? 18.059  -29.505 -16.905 1.00 82.39  ? 230 THR A C   1 
ATOM   1586 O O   . THR A 1 218 ? 18.228  -28.344 -17.330 1.00 91.40  ? 230 THR A O   1 
ATOM   1587 C CB  . THR A 1 218 ? 19.751  -29.620 -15.097 1.00 71.96  ? 230 THR A CB  1 
ATOM   1588 O OG1 . THR A 1 218 ? 21.091  -30.062 -14.904 1.00 72.36  ? 230 THR A OG1 1 
ATOM   1589 C CG2 . THR A 1 218 ? 18.894  -30.007 -13.906 1.00 74.27  ? 230 THR A CG2 1 
ATOM   1590 N N   . PRO A 1 219 ? 16.842  -30.093 -16.894 1.00 78.81  ? 231 PRO A N   1 
ATOM   1591 C CA  . PRO A 1 219 ? 15.672  -29.319 -17.268 1.00 79.79  ? 231 PRO A CA  1 
ATOM   1592 C C   . PRO A 1 219 ? 15.033  -28.745 -16.020 1.00 79.71  ? 231 PRO A C   1 
ATOM   1593 O O   . PRO A 1 219 ? 14.413  -29.483 -15.230 1.00 80.75  ? 231 PRO A O   1 
ATOM   1594 C CB  . PRO A 1 219 ? 14.793  -30.393 -17.918 1.00 76.98  ? 231 PRO A CB  1 
ATOM   1595 C CG  . PRO A 1 219 ? 15.285  -31.718 -17.356 1.00 82.87  ? 231 PRO A CG  1 
ATOM   1596 C CD  . PRO A 1 219 ? 16.591  -31.486 -16.617 1.00 75.65  ? 231 PRO A CD  1 
ATOM   1597 N N   . ALA A 1 220 ? 15.172  -27.431 -15.842 1.00 71.48  ? 232 ALA A N   1 
ATOM   1598 C CA  . ALA A 1 220 ? 14.558  -26.753 -14.676 1.00 72.29  ? 232 ALA A CA  1 
ATOM   1599 C C   . ALA A 1 220 ? 13.032  -26.816 -14.733 1.00 74.44  ? 232 ALA A C   1 
ATOM   1600 O O   . ALA A 1 220 ? 12.405  -27.045 -13.678 1.00 70.20  ? 232 ALA A O   1 
ATOM   1601 C CB  . ALA A 1 220 ? 15.054  -25.332 -14.607 1.00 81.90  ? 232 ALA A CB  1 
ATOM   1602 N N   . SER A 1 221 ? 12.454  -26.620 -15.922 1.00 76.84  ? 233 SER A N   1 
ATOM   1603 C CA  . SER A 1 221 ? 10.973  -26.558 -16.024 1.00 77.36  ? 233 SER A CA  1 
ATOM   1604 C C   . SER A 1 221 ? 10.449  -27.704 -16.890 1.00 81.13  ? 233 SER A C   1 
ATOM   1605 O O   . SER A 1 221 ? 10.909  -27.832 -18.042 1.00 76.34  ? 233 SER A O   1 
ATOM   1606 C CB  . SER A 1 221 ? 10.538  -25.250 -16.607 1.00 78.92  ? 233 SER A CB  1 
ATOM   1607 O OG  . SER A 1 221 ? 9.220   -25.347 -17.129 1.00 78.70  ? 233 SER A OG  1 
ATOM   1608 N N   . ALA A 1 222 ? 9.497   -28.472 -16.364 1.00 78.20  ? 234 ALA A N   1 
ATOM   1609 C CA  . ALA A 1 222 ? 8.891   -29.535 -17.191 1.00 66.71  ? 234 ALA A CA  1 
ATOM   1610 C C   . ALA A 1 222 ? 8.161   -28.907 -18.375 1.00 73.00  ? 234 ALA A C   1 
ATOM   1611 O O   . ALA A 1 222 ? 8.297   -29.421 -19.502 1.00 74.75  ? 234 ALA A O   1 
ATOM   1612 C CB  . ALA A 1 222 ? 7.948   -30.350 -16.342 1.00 66.03  ? 234 ALA A CB  1 
ATOM   1613 N N   . LYS A 1 223 ? 7.431   -27.814 -18.135 1.00 69.56  ? 235 LYS A N   1 
ATOM   1614 C CA  . LYS A 1 223 ? 6.616   -27.242 -19.235 1.00 75.95  ? 235 LYS A CA  1 
ATOM   1615 C C   . LYS A 1 223 ? 7.516   -26.754 -20.375 1.00 78.63  ? 235 LYS A C   1 
ATOM   1616 O O   . LYS A 1 223 ? 7.202   -27.037 -21.551 1.00 74.05  ? 235 LYS A O   1 
ATOM   1617 C CB  . LYS A 1 223 ? 5.797   -26.063 -18.706 1.00 81.32  ? 235 LYS A CB  1 
ATOM   1618 C CG  . LYS A 1 223 ? 4.859   -25.427 -19.719 1.00 84.30  ? 235 LYS A CG  1 
ATOM   1619 C CD  . LYS A 1 223 ? 4.032   -24.291 -19.130 1.00 87.16  ? 235 LYS A CD  1 
ATOM   1620 C CE  . LYS A 1 223 ? 3.132   -23.659 -20.143 1.00 82.99  ? 235 LYS A CE  1 
ATOM   1621 N NZ  . LYS A 1 223 ? 2.343   -22.568 -19.565 1.00 71.08  ? 235 LYS A NZ  1 
ATOM   1622 N N   . ASP A 1 224 ? 8.611   -26.076 -20.026 1.00 75.39  ? 236 ASP A N   1 
ATOM   1623 C CA  . ASP A 1 224 ? 9.537   -25.561 -21.068 1.00 75.59  ? 236 ASP A CA  1 
ATOM   1624 C C   . ASP A 1 224 ? 10.150  -26.745 -21.815 1.00 75.25  ? 236 ASP A C   1 
ATOM   1625 O O   . ASP A 1 224 ? 10.245  -26.688 -23.059 1.00 72.27  ? 236 ASP A O   1 
ATOM   1626 C CB  . ASP A 1 224 ? 10.577  -24.632 -20.466 1.00 76.60  ? 236 ASP A CB  1 
ATOM   1627 C CG  . ASP A 1 224 ? 10.016  -23.437 -19.712 1.00 89.09  ? 236 ASP A CG  1 
ATOM   1628 O OD1 . ASP A 1 224 ? 8.818   -23.476 -19.364 1.00 94.36  ? 236 ASP A OD1 1 
ATOM   1629 O OD2 . ASP A 1 224 ? 10.784  -22.482 -19.475 1.00 87.93  ? 236 ASP A OD2 1 
ATOM   1630 N N   . THR A 1 225 ? 10.527  -27.787 -21.072 1.00 73.80  ? 237 THR A N   1 
ATOM   1631 C CA  . THR A 1 225 ? 11.153  -28.960 -21.707 1.00 75.28  ? 237 THR A CA  1 
ATOM   1632 C C   . THR A 1 225 ? 10.150  -29.586 -22.639 1.00 76.45  ? 237 THR A C   1 
ATOM   1633 O O   . THR A 1 225 ? 10.529  -29.925 -23.775 1.00 73.96  ? 237 THR A O   1 
ATOM   1634 C CB  . THR A 1 225 ? 11.606  -29.939 -20.627 1.00 73.89  ? 237 THR A CB  1 
ATOM   1635 O OG1 . THR A 1 225 ? 12.350  -29.141 -19.714 1.00 81.61  ? 237 THR A OG1 1 
ATOM   1636 C CG2 . THR A 1 225 ? 12.478  -31.053 -21.177 1.00 59.33  ? 237 THR A CG2 1 
ATOM   1637 N N   . PHE A 1 226 ? 8.893   -29.679 -22.202 1.00 78.23  ? 238 PHE A N   1 
ATOM   1638 C CA  . PHE A 1 226 ? 7.880   -30.371 -23.036 1.00 78.70  ? 238 PHE A CA  1 
ATOM   1639 C C   . PHE A 1 226 ? 7.721   -29.607 -24.330 1.00 81.70  ? 238 PHE A C   1 
ATOM   1640 O O   . PHE A 1 226 ? 7.644   -30.230 -25.404 1.00 81.42  ? 238 PHE A O   1 
ATOM   1641 C CB  . PHE A 1 226 ? 6.546   -30.419 -22.288 1.00 77.40  ? 238 PHE A CB  1 
ATOM   1642 C CG  . PHE A 1 226 ? 5.325   -30.538 -23.189 1.00 91.46  ? 238 PHE A CG  1 
ATOM   1643 C CD1 . PHE A 1 226 ? 4.577   -29.418 -23.537 1.00 94.45  ? 238 PHE A CD1 1 
ATOM   1644 C CD2 . PHE A 1 226 ? 4.930   -31.772 -23.689 1.00 89.27  ? 238 PHE A CD2 1 
ATOM   1645 C CE1 . PHE A 1 226 ? 3.475   -29.534 -24.368 1.00 94.13  ? 238 PHE A CE1 1 
ATOM   1646 C CE2 . PHE A 1 226 ? 3.823   -31.880 -24.513 1.00 90.15  ? 238 PHE A CE2 1 
ATOM   1647 C CZ  . PHE A 1 226 ? 3.097   -30.763 -24.849 1.00 91.57  ? 238 PHE A CZ  1 
ATOM   1648 N N   . THR A 1 227 ? 7.688   -28.278 -24.235 1.00 78.34  ? 239 THR A N   1 
ATOM   1649 C CA  . THR A 1 227 ? 7.445   -27.479 -25.449 1.00 77.65  ? 239 THR A CA  1 
ATOM   1650 C C   . THR A 1 227 ? 8.578   -27.697 -26.422 1.00 77.76  ? 239 THR A C   1 
ATOM   1651 O O   . THR A 1 227 ? 8.300   -27.877 -27.625 1.00 77.91  ? 239 THR A O   1 
ATOM   1652 C CB  . THR A 1 227 ? 7.313   -26.011 -25.051 1.00 81.51  ? 239 THR A CB  1 
ATOM   1653 O OG1 . THR A 1 227 ? 6.487   -26.013 -23.892 1.00 71.07  ? 239 THR A OG1 1 
ATOM   1654 C CG2 . THR A 1 227 ? 6.671   -25.170 -26.138 1.00 85.72  ? 239 THR A CG2 1 
ATOM   1655 N N   . PHE A 1 228 ? 9.816   -27.710 -25.920 1.00 74.15  ? 240 PHE A N   1 
ATOM   1656 C CA  . PHE A 1 228 ? 10.991  -27.946 -26.796 1.00 76.80  ? 240 PHE A CA  1 
ATOM   1657 C C   . PHE A 1 228 ? 10.918  -29.343 -27.388 1.00 78.04  ? 240 PHE A C   1 
ATOM   1658 O O   . PHE A 1 228 ? 11.192  -29.512 -28.593 1.00 76.08  ? 240 PHE A O   1 
ATOM   1659 C CB  . PHE A 1 228 ? 12.169  -27.745 -25.843 1.00 79.56  ? 240 PHE A CB  1 
ATOM   1660 C CG  . PHE A 1 228 ? 13.562  -27.906 -26.433 1.00 71.80  ? 240 PHE A CG  1 
ATOM   1661 C CD1 . PHE A 1 228 ? 14.039  -27.015 -27.386 1.00 69.11  ? 240 PHE A CD1 1 
ATOM   1662 C CD2 . PHE A 1 228 ? 14.396  -28.934 -26.014 1.00 69.20  ? 240 PHE A CD2 1 
ATOM   1663 C CE1 . PHE A 1 228 ? 15.310  -27.160 -27.914 1.00 63.94  ? 240 PHE A CE1 1 
ATOM   1664 C CE2 . PHE A 1 228 ? 15.666  -29.073 -26.546 1.00 67.73  ? 240 PHE A CE2 1 
ATOM   1665 C CZ  . PHE A 1 228 ? 16.119  -28.188 -27.494 1.00 65.66  ? 240 PHE A CZ  1 
ATOM   1666 N N   . LEU A 1 229 ? 10.562  -30.327 -26.562 1.00 77.35  ? 241 LEU A N   1 
ATOM   1667 C CA  . LEU A 1 229 ? 10.425  -31.736 -27.018 1.00 78.79  ? 241 LEU A CA  1 
ATOM   1668 C C   . LEU A 1 229 ? 9.283   -31.919 -28.030 1.00 83.19  ? 241 LEU A C   1 
ATOM   1669 O O   . LEU A 1 229 ? 9.500   -32.649 -29.015 1.00 84.26  ? 241 LEU A O   1 
ATOM   1670 C CB  . LEU A 1 229 ? 10.243  -32.625 -25.791 1.00 75.97  ? 241 LEU A CB  1 
ATOM   1671 C CG  . LEU A 1 229 ? 11.480  -32.787 -24.905 1.00 74.82  ? 241 LEU A CG  1 
ATOM   1672 C CD1 . LEU A 1 229 ? 11.188  -33.676 -23.713 1.00 70.13  ? 241 LEU A CD1 1 
ATOM   1673 C CD2 . LEU A 1 229 ? 12.633  -33.335 -25.717 1.00 70.36  ? 241 LEU A CD2 1 
ATOM   1674 N N   . ASN A 1 230 ? 8.143   -31.247 -27.839 1.00 82.47  ? 242 ASN A N   1 
ATOM   1675 C CA  . ASN A 1 230 ? 6.935   -31.525 -28.671 1.00 88.52  ? 242 ASN A CA  1 
ATOM   1676 C C   . ASN A 1 230 ? 7.177   -31.219 -30.150 1.00 89.96  ? 242 ASN A C   1 
ATOM   1677 O O   . ASN A 1 230 ? 7.912   -30.251 -30.442 1.00 86.16  ? 242 ASN A O   1 
ATOM   1678 C CB  . ASN A 1 230 ? 5.711   -30.769 -28.164 1.00 90.20  ? 242 ASN A CB  1 
ATOM   1679 C CG  . ASN A 1 230 ? 4.423   -31.483 -28.497 1.00 82.51  ? 242 ASN A CG  1 
ATOM   1680 O OD1 . ASN A 1 230 ? 4.449   -32.628 -28.960 1.00 81.73  ? 242 ASN A OD1 1 
ATOM   1681 N ND2 . ASN A 1 230 ? 3.293   -30.830 -28.273 1.00 85.65  ? 242 ASN A ND2 1 
ATOM   1682 N N   . LYS A 1 231 ? 6.598   -32.043 -31.033 1.00 90.28  ? 243 LYS A N   1 
ATOM   1683 C CA  . LYS A 1 231 ? 6.813   -31.890 -32.497 1.00 82.86  ? 243 LYS A CA  1 
ATOM   1684 C C   . LYS A 1 231 ? 8.315   -32.067 -32.730 1.00 78.67  ? 243 LYS A C   1 
ATOM   1685 O O   . LYS A 1 231 ? 8.908   -31.259 -33.473 1.00 83.84  ? 243 LYS A O   1 
ATOM   1686 C CB  . LYS A 1 231 ? 6.222   -30.571 -33.007 1.00 86.93  ? 243 LYS A CB  1 
ATOM   1687 C CG  . LYS A 1 231 ? 4.720   -30.448 -32.803 1.00 93.40  ? 243 LYS A CG  1 
ATOM   1688 C CD  . LYS A 1 231 ? 4.349   -29.504 -31.667 1.00 110.57 ? 243 LYS A CD  1 
ATOM   1689 C CE  . LYS A 1 231 ? 3.685   -28.264 -32.170 1.00 103.23 ? 243 LYS A CE  1 
ATOM   1690 N NZ  . LYS A 1 231 ? 2.724   -28.574 -33.231 1.00 101.15 ? 243 LYS A NZ  1 
ATOM   1691 N N   . GLY A 1 232 ? 8.894   -33.097 -32.112 1.00 82.29  ? 244 GLY A N   1 
ATOM   1692 C CA  . GLY A 1 232 ? 10.346  -33.329 -32.199 1.00 81.18  ? 244 GLY A CA  1 
ATOM   1693 C C   . GLY A 1 232 ? 10.666  -34.809 -32.214 1.00 78.03  ? 244 GLY A C   1 
ATOM   1694 O O   . GLY A 1 232 ? 9.791   -35.610 -31.851 1.00 79.17  ? 244 GLY A O   1 
ATOM   1695 N N   . PHE A 1 233 ? 11.881  -35.172 -32.611 1.00 69.43  ? 245 PHE A N   1 
ATOM   1696 C CA  . PHE A 1 233 ? 12.312  -36.593 -32.572 1.00 69.17  ? 245 PHE A CA  1 
ATOM   1697 C C   . PHE A 1 233 ? 12.218  -37.015 -31.114 1.00 72.09  ? 245 PHE A C   1 
ATOM   1698 O O   . PHE A 1 233 ? 11.847  -38.171 -30.840 1.00 72.62  ? 245 PHE A O   1 
ATOM   1699 C CB  . PHE A 1 233 ? 13.731  -36.697 -33.131 1.00 66.94  ? 245 PHE A CB  1 
ATOM   1700 C CG  . PHE A 1 233 ? 14.315  -38.102 -33.161 1.00 70.30  ? 245 PHE A CG  1 
ATOM   1701 C CD1 . PHE A 1 233 ? 14.881  -38.666 -32.024 1.00 68.16  ? 245 PHE A CD1 1 
ATOM   1702 C CD2 . PHE A 1 233 ? 14.306  -38.850 -34.331 1.00 73.48  ? 245 PHE A CD2 1 
ATOM   1703 C CE1 . PHE A 1 233 ? 15.410  -39.945 -32.054 1.00 69.93  ? 245 PHE A CE1 1 
ATOM   1704 C CE2 . PHE A 1 233 ? 14.842  -40.127 -34.357 1.00 75.37  ? 245 PHE A CE2 1 
ATOM   1705 C CZ  . PHE A 1 233 ? 15.390  -40.671 -33.220 1.00 76.07  ? 245 PHE A CZ  1 
ATOM   1706 N N   . PHE A 1 234 ? 12.517  -36.103 -30.193 1.00 74.13  ? 246 PHE A N   1 
ATOM   1707 C CA  . PHE A 1 234 ? 12.564  -36.406 -28.735 1.00 76.95  ? 246 PHE A CA  1 
ATOM   1708 C C   . PHE A 1 234 ? 11.178  -36.173 -28.109 1.00 74.70  ? 246 PHE A C   1 
ATOM   1709 O O   . PHE A 1 234 ? 11.073  -36.193 -26.870 1.00 75.90  ? 246 PHE A O   1 
ATOM   1710 C CB  . PHE A 1 234 ? 13.732  -35.601 -28.162 1.00 73.11  ? 246 PHE A CB  1 
ATOM   1711 C CG  . PHE A 1 234 ? 15.051  -35.994 -28.812 1.00 70.02  ? 246 PHE A CG  1 
ATOM   1712 C CD1 . PHE A 1 234 ? 15.605  -37.248 -28.586 1.00 67.68  ? 246 PHE A CD1 1 
ATOM   1713 C CD2 . PHE A 1 234 ? 15.713  -35.126 -29.671 1.00 67.38  ? 246 PHE A CD2 1 
ATOM   1714 C CE1 . PHE A 1 234 ? 16.798  -37.613 -29.186 1.00 64.01  ? 246 PHE A CE1 1 
ATOM   1715 C CE2 . PHE A 1 234 ? 16.904  -35.498 -30.271 1.00 69.70  ? 246 PHE A CE2 1 
ATOM   1716 C CZ  . PHE A 1 234 ? 17.444  -36.739 -30.027 1.00 66.92  ? 246 PHE A CZ  1 
ATOM   1717 N N   . ALA A 1 235 ? 10.144  -35.978 -28.932 1.00 72.25  ? 247 ALA A N   1 
ATOM   1718 C CA  . ALA A 1 235 ? 8.767   -35.704 -28.444 1.00 74.46  ? 247 ALA A CA  1 
ATOM   1719 C C   . ALA A 1 235 ? 8.306   -36.877 -27.581 1.00 68.10  ? 247 ALA A C   1 
ATOM   1720 O O   . ALA A 1 235 ? 7.525   -36.658 -26.641 1.00 61.69  ? 247 ALA A O   1 
ATOM   1721 C CB  . ALA A 1 235 ? 7.814   -35.484 -29.592 1.00 76.55  ? 247 ALA A CB  1 
ATOM   1722 N N   . GLY A 1 236 ? 8.757   -38.087 -27.894 1.00 70.34  ? 248 GLY A N   1 
ATOM   1723 C CA  . GLY A 1 236 ? 8.330   -39.278 -27.140 1.00 70.91  ? 248 GLY A CA  1 
ATOM   1724 C C   . GLY A 1 236 ? 8.722   -39.089 -25.688 1.00 75.74  ? 248 GLY A C   1 
ATOM   1725 O O   . GLY A 1 236 ? 7.953   -39.527 -24.812 1.00 76.13  ? 248 GLY A O   1 
ATOM   1726 N N   . PHE A 1 237 ? 9.872   -38.467 -25.430 1.00 75.51  ? 249 PHE A N   1 
ATOM   1727 C CA  . PHE A 1 237 ? 10.272  -38.168 -24.031 1.00 73.62  ? 249 PHE A CA  1 
ATOM   1728 C C   . PHE A 1 237 ? 9.230   -37.254 -23.399 1.00 76.88  ? 249 PHE A C   1 
ATOM   1729 O O   . PHE A 1 237 ? 8.924   -37.435 -22.207 1.00 77.36  ? 249 PHE A O   1 
ATOM   1730 C CB  . PHE A 1 237 ? 11.572  -37.369 -23.974 1.00 69.39  ? 249 PHE A CB  1 
ATOM   1731 C CG  . PHE A 1 237 ? 12.865  -38.155 -24.103 1.00 69.68  ? 249 PHE A CG  1 
ATOM   1732 C CD1 . PHE A 1 237 ? 13.364  -38.883 -23.031 1.00 73.68  ? 249 PHE A CD1 1 
ATOM   1733 C CD2 . PHE A 1 237 ? 13.590  -38.140 -25.288 1.00 68.29  ? 249 PHE A CD2 1 
ATOM   1734 C CE1 . PHE A 1 237 ? 14.550  -39.585 -23.147 1.00 65.99  ? 249 PHE A CE1 1 
ATOM   1735 C CE2 . PHE A 1 237 ? 14.775  -38.845 -25.399 1.00 67.05  ? 249 PHE A CE2 1 
ATOM   1736 C CZ  . PHE A 1 237 ? 15.252  -39.563 -24.328 1.00 62.92  ? 249 PHE A CZ  1 
ATOM   1737 N N   . ALA A 1 238 ? 8.711   -36.282 -24.155 1.00 68.27  ? 250 ALA A N   1 
ATOM   1738 C CA  . ALA A 1 238 ? 7.651   -35.394 -23.619 1.00 71.30  ? 250 ALA A CA  1 
ATOM   1739 C C   . ALA A 1 238 ? 6.412   -36.223 -23.276 1.00 70.61  ? 250 ALA A C   1 
ATOM   1740 O O   . ALA A 1 238 ? 5.798   -35.967 -22.223 1.00 62.04  ? 250 ALA A O   1 
ATOM   1741 C CB  . ALA A 1 238 ? 7.317   -34.306 -24.610 1.00 72.61  ? 250 ALA A CB  1 
ATOM   1742 N N   . VAL A 1 239 ? 6.065   -37.197 -24.120 1.00 67.28  ? 251 VAL A N   1 
ATOM   1743 C CA  . VAL A 1 239 ? 4.912   -38.090 -23.801 1.00 70.52  ? 251 VAL A CA  1 
ATOM   1744 C C   . VAL A 1 239 ? 5.247   -38.852 -22.512 1.00 73.59  ? 251 VAL A C   1 
ATOM   1745 O O   . VAL A 1 239 ? 4.354   -38.975 -21.648 1.00 70.28  ? 251 VAL A O   1 
ATOM   1746 C CB  . VAL A 1 239 ? 4.629   -39.072 -24.951 1.00 72.59  ? 251 VAL A CB  1 
ATOM   1747 C CG1 . VAL A 1 239 ? 3.371   -39.894 -24.701 1.00 77.61  ? 251 VAL A CG1 1 
ATOM   1748 C CG2 . VAL A 1 239 ? 4.559   -38.372 -26.302 1.00 72.01  ? 251 VAL A CG2 1 
ATOM   1749 N N   . ALA A 1 240 ? 6.493   -39.312 -22.379 1.00 74.05  ? 252 ALA A N   1 
ATOM   1750 C CA  . ALA A 1 240 ? 6.914   -40.001 -21.139 1.00 74.21  ? 252 ALA A CA  1 
ATOM   1751 C C   . ALA A 1 240 ? 6.831   -39.001 -19.993 1.00 71.97  ? 252 ALA A C   1 
ATOM   1752 O O   . ALA A 1 240 ? 6.419   -39.374 -18.878 1.00 65.95  ? 252 ALA A O   1 
ATOM   1753 C CB  . ALA A 1 240 ? 8.313   -40.542 -21.293 1.00 72.24  ? 252 ALA A CB  1 
ATOM   1754 N N   . GLY A 1 241 ? 7.223   -37.758 -20.268 1.00 66.19  ? 253 GLY A N   1 
ATOM   1755 C CA  . GLY A 1 241 ? 7.100   -36.740 -19.243 1.00 64.74  ? 253 GLY A CA  1 
ATOM   1756 C C   . GLY A 1 241 ? 5.673   -36.564 -18.767 1.00 69.60  ? 253 GLY A C   1 
ATOM   1757 O O   . GLY A 1 241 ? 5.396   -36.591 -17.559 1.00 72.02  ? 253 GLY A O   1 
ATOM   1758 N N   . VAL A 1 242 ? 4.773   -36.330 -19.724 1.00 64.52  ? 254 VAL A N   1 
ATOM   1759 C CA  . VAL A 1 242 ? 3.337   -36.131 -19.378 1.00 62.93  ? 254 VAL A CA  1 
ATOM   1760 C C   . VAL A 1 242 ? 2.883   -37.344 -18.563 1.00 64.30  ? 254 VAL A C   1 
ATOM   1761 O O   . VAL A 1 242 ? 2.263   -37.149 -17.501 1.00 61.65  ? 254 VAL A O   1 
ATOM   1762 C CB  . VAL A 1 242 ? 2.489   -35.968 -20.652 1.00 60.73  ? 254 VAL A CB  1 
ATOM   1763 C CG1 . VAL A 1 242 ? 0.995   -36.036 -20.359 1.00 52.02  ? 254 VAL A CG1 1 
ATOM   1764 C CG2 . VAL A 1 242 ? 2.833   -34.688 -21.403 1.00 66.11  ? 254 VAL A CG2 1 
ATOM   1765 N N   . SER A 1 243 ? 3.212   -38.546 -19.035 1.00 65.39  ? 255 SER A N   1 
ATOM   1766 C CA  . SER A 1 243 ? 2.713   -39.756 -18.339 1.00 68.68  ? 255 SER A CA  1 
ATOM   1767 C C   . SER A 1 243 ? 3.268   -39.808 -16.912 1.00 74.68  ? 255 SER A C   1 
ATOM   1768 O O   . SER A 1 243 ? 2.486   -40.102 -15.990 1.00 72.87  ? 255 SER A O   1 
ATOM   1769 C CB  . SER A 1 243 ? 3.085   -41.000 -19.095 1.00 77.08  ? 255 SER A CB  1 
ATOM   1770 O OG  . SER A 1 243 ? 3.151   -42.120 -18.224 1.00 80.51  ? 255 SER A OG  1 
ATOM   1771 N N   . GLY A 1 244 ? 4.552   -39.489 -16.737 1.00 70.51  ? 256 GLY A N   1 
ATOM   1772 C CA  . GLY A 1 244 ? 5.118   -39.486 -15.379 1.00 70.04  ? 256 GLY A CA  1 
ATOM   1773 C C   . GLY A 1 244 ? 4.448   -38.445 -14.511 1.00 72.06  ? 256 GLY A C   1 
ATOM   1774 O O   . GLY A 1 244 ? 4.037   -38.775 -13.388 1.00 68.43  ? 256 GLY A O   1 
ATOM   1775 N N   . LEU A 1 245 ? 4.224   -37.253 -15.059 1.00 65.75  ? 257 LEU A N   1 
ATOM   1776 C CA  . LEU A 1 245 ? 3.612   -36.173 -14.251 1.00 68.74  ? 257 LEU A CA  1 
ATOM   1777 C C   . LEU A 1 245 ? 2.208   -36.646 -13.857 1.00 70.50  ? 257 LEU A C   1 
ATOM   1778 O O   . LEU A 1 245 ? 1.805   -36.436 -12.702 1.00 71.57  ? 257 LEU A O   1 
ATOM   1779 C CB  . LEU A 1 245 ? 3.586   -34.869 -15.043 1.00 63.08  ? 257 LEU A CB  1 
ATOM   1780 C CG  . LEU A 1 245 ? 4.712   -33.880 -14.729 1.00 64.10  ? 257 LEU A CG  1 
ATOM   1781 C CD1 . LEU A 1 245 ? 4.223   -32.450 -14.860 1.00 61.52  ? 257 LEU A CD1 1 
ATOM   1782 C CD2 . LEU A 1 245 ? 5.234   -34.136 -13.331 1.00 65.17  ? 257 LEU A CD2 1 
ATOM   1783 N N   . ALA A 1 246 ? 1.509   -37.286 -14.792 1.00 69.71  ? 258 ALA A N   1 
ATOM   1784 C CA  . ALA A 1 246 ? 0.145   -37.788 -14.518 1.00 68.96  ? 258 ALA A CA  1 
ATOM   1785 C C   . ALA A 1 246 ? 0.177   -38.851 -13.420 1.00 74.01  ? 258 ALA A C   1 
ATOM   1786 O O   . ALA A 1 246 ? -0.730  -38.867 -12.571 1.00 72.88  ? 258 ALA A O   1 
ATOM   1787 C CB  . ALA A 1 246 ? -0.446  -38.329 -15.794 1.00 70.84  ? 258 ALA A CB  1 
ATOM   1788 N N   . LEU A 1 247 ? 1.174   -39.737 -13.449 1.00 74.45  ? 259 LEU A N   1 
ATOM   1789 C CA  . LEU A 1 247 ? 1.280   -40.737 -12.358 1.00 75.01  ? 259 LEU A CA  1 
ATOM   1790 C C   . LEU A 1 247 ? 1.524   -40.014 -11.026 1.00 80.93  ? 259 LEU A C   1 
ATOM   1791 O O   . LEU A 1 247 ? 0.885   -40.397 -10.031 1.00 76.90  ? 259 LEU A O   1 
ATOM   1792 C CB  . LEU A 1 247 ? 2.416   -41.706 -12.675 1.00 73.99  ? 259 LEU A CB  1 
ATOM   1793 C CG  . LEU A 1 247 ? 2.235   -42.577 -13.921 1.00 78.10  ? 259 LEU A CG  1 
ATOM   1794 C CD1 . LEU A 1 247 ? 3.580   -42.973 -14.504 1.00 79.61  ? 259 LEU A CD1 1 
ATOM   1795 C CD2 . LEU A 1 247 ? 1.409   -43.806 -13.597 1.00 67.52  ? 259 LEU A CD2 1 
ATOM   1796 N N   . ALA A 1 248 ? 2.399   -39.003 -11.018 1.00 79.69  ? 260 ALA A N   1 
ATOM   1797 C CA  . ALA A 1 248 ? 2.679   -38.220 -9.789  1.00 80.86  ? 260 ALA A CA  1 
ATOM   1798 C C   . ALA A 1 248 ? 1.442   -37.455 -9.322  1.00 82.38  ? 260 ALA A C   1 
ATOM   1799 O O   . ALA A 1 248 ? 1.201   -37.396 -8.102  1.00 81.00  ? 260 ALA A O   1 
ATOM   1800 C CB  . ALA A 1 248 ? 3.819   -37.271 -10.044 1.00 80.02  ? 260 ALA A CB  1 
ATOM   1801 N N   . HIS A 1 249 ? 0.696   -36.872 -10.261 1.00 83.43  ? 261 HIS A N   1 
ATOM   1802 C CA  . HIS A 1 249 ? -0.471  -36.026 -9.891  1.00 83.40  ? 261 HIS A CA  1 
ATOM   1803 C C   . HIS A 1 249 ? -1.734  -36.724 -10.390 1.00 84.20  ? 261 HIS A C   1 
ATOM   1804 O O   . HIS A 1 249 ? -2.035  -36.654 -11.594 1.00 83.20  ? 261 HIS A O   1 
ATOM   1805 C CB  . HIS A 1 249 ? -0.276  -34.617 -10.453 1.00 86.19  ? 261 HIS A CB  1 
ATOM   1806 C CG  . HIS A 1 249 ? 1.085   -34.063 -10.197 1.00 83.41  ? 261 HIS A CG  1 
ATOM   1807 N ND1 . HIS A 1 249 ? 1.419   -33.437 -9.016  1.00 85.89  ? 261 HIS A ND1 1 
ATOM   1808 C CD2 . HIS A 1 249 ? 2.191   -34.040 -10.951 1.00 77.38  ? 261 HIS A CD2 1 
ATOM   1809 C CE1 . HIS A 1 249 ? 2.685   -33.052 -9.070  1.00 85.18  ? 261 HIS A CE1 1 
ATOM   1810 N NE2 . HIS A 1 249 ? 3.174   -33.411 -10.235 1.00 80.74  ? 261 HIS A NE2 1 
ATOM   1811 N N   . PRO A 1 250 ? -2.522  -37.370 -9.511  1.00 92.68  ? 262 PRO A N   1 
ATOM   1812 C CA  . PRO A 1 250 ? -3.667  -38.185 -9.949  1.00 92.46  ? 262 PRO A CA  1 
ATOM   1813 C C   . PRO A 1 250 ? -4.904  -37.387 -10.299 1.00 88.95  ? 262 PRO A C   1 
ATOM   1814 O O   . PRO A 1 250 ? -5.785  -37.935 -10.974 1.00 87.34  ? 262 PRO A O   1 
ATOM   1815 C CB  . PRO A 1 250 ? -3.952  -39.089 -8.738  1.00 87.27  ? 262 PRO A CB  1 
ATOM   1816 C CG  . PRO A 1 250 ? -2.967  -38.703 -7.680  1.00 91.58  ? 262 PRO A CG  1 
ATOM   1817 C CD  . PRO A 1 250 ? -2.396  -37.369 -8.050  1.00 96.76  ? 262 PRO A CD  1 
ATOM   1818 N N   . ASP A 1 251 ? -5.029  -36.143 -9.822  1.00 91.29  ? 263 ASP A N   1 
ATOM   1819 C CA  . ASP A 1 251 ? -6.058  -35.271 -10.368 1.00 90.96  ? 263 ASP A CA  1 
ATOM   1820 C C   . ASP A 1 251 ? -5.740  -34.941 -11.815 1.00 88.34  ? 263 ASP A C   1 
ATOM   1821 O O   . ASP A 1 251 ? -6.648  -34.700 -12.619 1.00 91.28  ? 263 ASP A O   1 
ATOM   1822 C CB  . ASP A 1 251 ? -6.188  -33.984 -9.548  1.00 91.46  ? 263 ASP A CB  1 
ATOM   1823 C CG  . ASP A 1 251 ? -4.859  -33.292 -9.322  1.00 94.09  ? 263 ASP A CG  1 
ATOM   1824 O OD1 . ASP A 1 251 ? -3.799  -33.870 -9.658  1.00 95.83  ? 263 ASP A OD1 1 
ATOM   1825 O OD2 . ASP A 1 251 ? -4.879  -32.156 -8.799  1.00 94.43  ? 263 ASP A OD2 1 
ATOM   1826 N N   . MET A 1 252 ? -4.457  -34.941 -12.164 1.00 80.17  ? 264 MET A N   1 
ATOM   1827 C CA  . MET A 1 252 ? -4.099  -34.771 -13.556 1.00 80.35  ? 264 MET A CA  1 
ATOM   1828 C C   . MET A 1 252 ? -4.404  -36.026 -14.360 1.00 78.01  ? 264 MET A C   1 
ATOM   1829 O O   . MET A 1 252 ? -4.840  -35.932 -15.505 1.00 82.00  ? 264 MET A O   1 
ATOM   1830 C CB  . MET A 1 252 ? -2.635  -34.368 -13.663 1.00 81.70  ? 264 MET A CB  1 
ATOM   1831 C CG  . MET A 1 252 ? -1.941  -34.875 -14.898 1.00 79.08  ? 264 MET A CG  1 
ATOM   1832 S SD  . MET A 1 252 ? -0.376  -34.017 -15.019 1.00 75.93  ? 264 MET A SD  1 
ATOM   1833 C CE  . MET A 1 252 ? 0.229   -34.567 -16.607 1.00 68.11  ? 264 MET A CE  1 
ATOM   1834 N N   . GLU A 1 253 ? -4.225  -37.207 -13.785 1.00 77.78  ? 265 GLU A N   1 
ATOM   1835 C CA  . GLU A 1 253 ? -4.707  -38.404 -14.464 1.00 78.86  ? 265 GLU A CA  1 
ATOM   1836 C C   . GLU A 1 253 ? -6.209  -38.334 -14.721 1.00 88.98  ? 265 GLU A C   1 
ATOM   1837 O O   . GLU A 1 253 ? -6.666  -38.555 -15.850 1.00 90.39  ? 265 GLU A O   1 
ATOM   1838 C CB  . GLU A 1 253 ? -4.368  -39.641 -13.652 1.00 76.01  ? 265 GLU A CB  1 
ATOM   1839 C CG  . GLU A 1 253 ? -4.670  -40.910 -14.388 1.00 79.75  ? 265 GLU A CG  1 
ATOM   1840 C CD  . GLU A 1 253 ? -3.632  -41.211 -15.433 1.00 77.06  ? 265 GLU A CD  1 
ATOM   1841 O OE1 . GLU A 1 253 ? -2.671  -40.438 -15.545 1.00 75.78  ? 265 GLU A OE1 1 
ATOM   1842 O OE2 . GLU A 1 253 ? -3.756  -42.237 -16.125 1.00 80.23  ? 265 GLU A OE2 1 
ATOM   1843 N N   . ALA A 1 254 ? -6.994  -38.056 -13.672 1.00 89.39  ? 266 ALA A N   1 
ATOM   1844 C CA  . ALA A 1 254 ? -8.436  -37.863 -13.820 1.00 86.06  ? 266 ALA A CA  1 
ATOM   1845 C C   . ALA A 1 254 ? -8.762  -36.951 -14.995 1.00 94.88  ? 266 ALA A C   1 
ATOM   1846 O O   . ALA A 1 254 ? -9.671  -37.241 -15.783 1.00 99.98  ? 266 ALA A O   1 
ATOM   1847 C CB  . ALA A 1 254 ? -9.031  -37.284 -12.531 1.00 90.95  ? 266 ALA A CB  1 
ATOM   1848 N N   . PHE A 1 255 ? -8.033  -35.838 -15.124 1.00 94.41  ? 267 PHE A N   1 
ATOM   1849 C CA  . PHE A 1 255 ? -8.223  -34.955 -16.272 1.00 92.98  ? 267 PHE A CA  1 
ATOM   1850 C C   . PHE A 1 255 ? -7.980  -35.698 -17.578 1.00 90.20  ? 267 PHE A C   1 
ATOM   1851 O O   . PHE A 1 255 ? -8.761  -35.587 -18.528 1.00 98.60  ? 267 PHE A O   1 
ATOM   1852 C CB  . PHE A 1 255 ? -7.285  -33.744 -16.171 1.00 87.14  ? 267 PHE A CB  1 
ATOM   1853 C CG  . PHE A 1 255 ? -7.770  -32.498 -16.906 1.00 88.92  ? 267 PHE A CG  1 
ATOM   1854 C CD1 . PHE A 1 255 ? -8.911  -31.829 -16.514 1.00 91.68  ? 267 PHE A CD1 1 
ATOM   1855 C CD2 . PHE A 1 255 ? -7.065  -32.001 -17.997 1.00 90.21  ? 267 PHE A CD2 1 
ATOM   1856 C CE1 . PHE A 1 255 ? -9.326  -30.685 -17.184 1.00 92.31  ? 267 PHE A CE1 1 
ATOM   1857 C CE2 . PHE A 1 255 ? -7.479  -30.865 -18.672 1.00 86.61  ? 267 PHE A CE2 1 
ATOM   1858 C CZ  . PHE A 1 255 ? -8.606  -30.210 -18.262 1.00 91.34  ? 267 PHE A CZ  1 
ATOM   1859 N N   . LEU A 1 256 ? -6.915  -36.486 -17.632 1.00 84.40  ? 268 LEU A N   1 
ATOM   1860 C CA  . LEU A 1 256 ? -6.349  -36.841 -18.921 1.00 85.14  ? 268 LEU A CA  1 
ATOM   1861 C C   . LEU A 1 256 ? -7.139  -37.973 -19.562 1.00 98.20  ? 268 LEU A C   1 
ATOM   1862 O O   . LEU A 1 256 ? -7.645  -37.834 -20.681 1.00 99.99  ? 268 LEU A O   1 
ATOM   1863 C CB  . LEU A 1 256 ? -4.901  -37.253 -18.727 1.00 89.57  ? 268 LEU A CB  1 
ATOM   1864 C CG  . LEU A 1 256 ? -3.928  -37.141 -19.888 1.00 87.30  ? 268 LEU A CG  1 
ATOM   1865 C CD1 . LEU A 1 256 ? -2.532  -37.506 -19.349 1.00 80.90  ? 268 LEU A CD1 1 
ATOM   1866 C CD2 . LEU A 1 256 ? -4.337  -37.889 -21.141 1.00 93.41  ? 268 LEU A CD2 1 
ATOM   1867 N N   . GLU A 1 257 ? -7.235  -39.126 -18.855 1.00 99.65  ? 269 GLU A N   1 
ATOM   1868 C CA  . GLU A 1 257 ? -7.916  -40.355 -19.265 1.00 97.08  ? 269 GLU A CA  1 
ATOM   1869 C C   . GLU A 1 257 ? -9.083  -40.148 -20.218 1.00 98.88  ? 269 GLU A C   1 
ATOM   1870 O O   . GLU A 1 257 ? -9.148  -40.831 -21.247 1.00 103.58 ? 269 GLU A O   1 
ATOM   1871 C CB  . GLU A 1 257 ? -8.393  -41.131 -18.039 1.00 100.65 ? 269 GLU A CB  1 
ATOM   1872 C CG  . GLU A 1 257 ? -7.301  -41.707 -17.171 1.00 103.72 ? 269 GLU A CG  1 
ATOM   1873 C CD  . GLU A 1 257 ? -7.038  -43.186 -17.502 1.00 117.92 ? 269 GLU A CD  1 
ATOM   1874 O OE1 . GLU A 1 257 ? -6.899  -43.519 -18.702 1.00 119.83 ? 269 GLU A OE1 1 
ATOM   1875 O OE2 . GLU A 1 257 ? -6.991  -44.012 -16.554 1.00 123.24 ? 269 GLU A OE2 1 
ATOM   1876 N N   . PRO A 1 258 ? -10.025 -39.246 -19.920 1.00 96.69  ? 270 PRO A N   1 
ATOM   1877 C CA  . PRO A 1 258 ? -11.171 -39.085 -20.841 1.00 110.76 ? 270 PRO A CA  1 
ATOM   1878 C C   . PRO A 1 258 ? -10.803 -38.471 -22.174 1.00 107.70 ? 270 PRO A C   1 
ATOM   1879 O O   . PRO A 1 258 ? -11.422 -38.784 -23.205 1.00 104.19 ? 270 PRO A O   1 
ATOM   1880 C CB  . PRO A 1 258 ? -12.128 -38.160 -20.075 1.00 110.33 ? 270 PRO A CB  1 
ATOM   1881 C CG  . PRO A 1 258 ? -11.367 -37.644 -18.913 1.00 103.40 ? 270 PRO A CG  1 
ATOM   1882 C CD  . PRO A 1 258 ? -10.206 -38.503 -18.659 1.00 95.13  ? 270 PRO A CD  1 
ATOM   1883 N N   . ARG A 1 259 ? -9.833  -37.567 -22.157 1.00 104.07 ? 271 ARG A N   1 
ATOM   1884 C CA  . ARG A 1 259 ? -9.478  -36.766 -23.310 1.00 99.53  ? 271 ARG A CA  1 
ATOM   1885 C C   . ARG A 1 259 ? -8.625  -37.529 -24.312 1.00 95.44  ? 271 ARG A C   1 
ATOM   1886 O O   . ARG A 1 259 ? -8.387  -37.039 -25.421 1.00 95.21  ? 271 ARG A O   1 
ATOM   1887 C CB  . ARG A 1 259 ? -8.771  -35.516 -22.818 1.00 88.08  ? 271 ARG A CB  1 
ATOM   1888 C CG  . ARG A 1 259 ? -9.613  -34.554 -22.048 1.00 85.50  ? 271 ARG A CG  1 
ATOM   1889 C CD  . ARG A 1 259 ? -8.822  -33.275 -21.805 1.00 91.25  ? 271 ARG A CD  1 
ATOM   1890 N NE  . ARG A 1 259 ? -9.611  -32.095 -21.451 1.00 94.86  ? 271 ARG A NE  1 
ATOM   1891 C CZ  . ARG A 1 259 ? -10.546 -32.033 -20.507 1.00 98.59  ? 271 ARG A CZ  1 
ATOM   1892 N NH1 . ARG A 1 259 ? -10.786 -33.047 -19.693 1.00 90.12  ? 271 ARG A NH1 1 
ATOM   1893 N NH2 . ARG A 1 259 ? -11.252 -30.912 -20.368 1.00 99.52  ? 271 ARG A NH2 1 
ATOM   1894 N N   . LEU A 1 260 ? -8.191  -38.727 -23.959 1.00 91.15  ? 272 LEU A N   1 
ATOM   1895 C CA  . LEU A 1 260 ? -7.416  -39.551 -24.865 1.00 96.43  ? 272 LEU A CA  1 
ATOM   1896 C C   . LEU A 1 260 ? -8.243  -39.976 -26.060 1.00 97.84  ? 272 LEU A C   1 
ATOM   1897 O O   . LEU A 1 260 ? -9.192  -40.753 -25.912 1.00 103.90 ? 272 LEU A O   1 
ATOM   1898 C CB  . LEU A 1 260 ? -6.907  -40.777 -24.122 1.00 98.70  ? 272 LEU A CB  1 
ATOM   1899 C CG  . LEU A 1 260 ? -5.836  -40.375 -23.136 1.00 95.74  ? 272 LEU A CG  1 
ATOM   1900 C CD1 . LEU A 1 260 ? -5.518  -41.551 -22.261 1.00 87.39  ? 272 LEU A CD1 1 
ATOM   1901 C CD2 . LEU A 1 260 ? -4.622  -39.892 -23.932 1.00 91.99  ? 272 LEU A CD2 1 
ATOM   1902 N N   . ASN A 1 261 ? -7.903  -39.485 -27.244 1.00 93.53  ? 273 ASN A N   1 
ATOM   1903 C CA  . ASN A 1 261 ? -8.487  -40.104 -28.411 1.00 95.77  ? 273 ASN A CA  1 
ATOM   1904 C C   . ASN A 1 261 ? -7.966  -41.534 -28.524 1.00 92.93  ? 273 ASN A C   1 
ATOM   1905 O O   . ASN A 1 261 ? -7.002  -41.922 -27.869 1.00 92.12  ? 273 ASN A O   1 
ATOM   1906 C CB  . ASN A 1 261 ? -8.191  -39.281 -29.659 1.00 99.03  ? 273 ASN A CB  1 
ATOM   1907 C CG  . ASN A 1 261 ? -6.716  -39.158 -29.946 1.00 98.15  ? 273 ASN A CG  1 
ATOM   1908 O OD1 . ASN A 1 261 ? -5.944  -40.100 -29.763 1.00 91.65  ? 273 ASN A OD1 1 
ATOM   1909 N ND2 . ASN A 1 261 ? -6.311  -37.977 -30.404 1.00 97.01  ? 273 ASN A ND2 1 
ATOM   1910 N N   . ALA A 1 262 ? -8.629  -42.324 -29.369 1.00 96.23  ? 274 ALA A N   1 
ATOM   1911 C CA  . ALA A 1 262 ? -8.302  -43.744 -29.481 1.00 103.81 ? 274 ALA A CA  1 
ATOM   1912 C C   . ALA A 1 262 ? -6.806  -43.975 -29.674 1.00 95.00  ? 274 ALA A C   1 
ATOM   1913 O O   . ALA A 1 262 ? -6.248  -44.951 -29.164 1.00 92.21  ? 274 ALA A O   1 
ATOM   1914 C CB  . ALA A 1 262 ? -9.095  -44.372 -30.629 1.00 100.80 ? 274 ALA A CB  1 
ATOM   1915 N N   . LYS A 1 263 ? -6.143  -43.089 -30.413 1.00 98.33  ? 275 LYS A N   1 
ATOM   1916 C CA  . LYS A 1 263 ? -4.690  -43.161 -30.519 1.00 99.05  ? 275 LYS A CA  1 
ATOM   1917 C C   . LYS A 1 263 ? -4.062  -42.988 -29.149 1.00 95.46  ? 275 LYS A C   1 
ATOM   1918 O O   . LYS A 1 263 ? -3.337  -43.863 -28.665 1.00 90.16  ? 275 LYS A O   1 
ATOM   1919 C CB  . LYS A 1 263 ? -4.174  -42.065 -31.448 1.00 99.26  ? 275 LYS A CB  1 
ATOM   1920 C CG  . LYS A 1 263 ? -2.802  -42.320 -32.006 1.00 91.80  ? 275 LYS A CG  1 
ATOM   1921 C CD  . LYS A 1 263 ? -2.924  -42.896 -33.404 1.00 97.13  ? 275 LYS A CD  1 
ATOM   1922 C CE  . LYS A 1 263 ? -3.335  -41.764 -34.365 1.00 100.02 ? 275 LYS A CE  1 
ATOM   1923 N NZ  . LYS A 1 263 ? -3.726  -42.204 -35.724 1.00 93.91  ? 275 LYS A NZ  1 
ATOM   1924 N N   . GLY A 1 264 ? -4.378  -41.863 -28.495 1.00 97.25  ? 276 GLY A N   1 
ATOM   1925 C CA  . GLY A 1 264 ? -3.738  -41.499 -27.242 1.00 92.96  ? 276 GLY A CA  1 
ATOM   1926 C C   . GLY A 1 264 ? -3.905  -42.523 -26.145 1.00 92.29  ? 276 GLY A C   1 
ATOM   1927 O O   . GLY A 1 264 ? -3.029  -42.661 -25.292 1.00 87.68  ? 276 GLY A O   1 
ATOM   1928 N N   . LYS A 1 265 ? -5.022  -43.250 -26.143 1.00 94.04  ? 277 LYS A N   1 
ATOM   1929 C CA  . LYS A 1 265 ? -5.186  -44.315 -25.164 1.00 91.21  ? 277 LYS A CA  1 
ATOM   1930 C C   . LYS A 1 265 ? -4.102  -45.377 -25.335 1.00 87.68  ? 277 LYS A C   1 
ATOM   1931 O O   . LYS A 1 265 ? -3.601  -45.939 -24.355 1.00 83.85  ? 277 LYS A O   1 
ATOM   1932 C CB  . LYS A 1 265 ? -6.591  -44.917 -25.282 1.00 92.05  ? 277 LYS A CB  1 
ATOM   1933 C CG  . LYS A 1 265 ? -7.666  -44.209 -24.444 1.00 94.27  ? 277 LYS A CG  1 
ATOM   1934 C CD  . LYS A 1 265 ? -9.067  -44.670 -24.811 1.00 93.05  ? 277 LYS A CD  1 
ATOM   1935 C CE  . LYS A 1 265 ? -10.113 -43.730 -24.253 1.00 88.95  ? 277 LYS A CE  1 
ATOM   1936 N NZ  . LYS A 1 265 ? -11.324 -43.718 -25.110 1.00 95.12  ? 277 LYS A NZ  1 
ATOM   1937 N N   . GLN A 1 266 ? -3.697  -45.632 -26.568 1.00 88.67  ? 278 GLN A N   1 
ATOM   1938 C CA  . GLN A 1 266 ? -2.708  -46.662 -26.834 1.00 96.41  ? 278 GLN A CA  1 
ATOM   1939 C C   . GLN A 1 266 ? -1.283  -46.152 -26.771 1.00 95.34  ? 278 GLN A C   1 
ATOM   1940 O O   . GLN A 1 266 ? -0.369  -46.928 -26.456 1.00 89.80  ? 278 GLN A O   1 
ATOM   1941 C CB  . GLN A 1 266 ? -2.953  -47.280 -28.203 1.00 102.62 ? 278 GLN A CB  1 
ATOM   1942 C CG  . GLN A 1 266 ? -4.145  -48.177 -28.257 1.00 97.68  ? 278 GLN A CG  1 
ATOM   1943 C CD  . GLN A 1 266 ? -4.493  -48.487 -29.677 1.00 107.83 ? 278 GLN A CD  1 
ATOM   1944 O OE1 . GLN A 1 266 ? -4.319  -49.619 -30.135 1.00 120.20 ? 278 GLN A OE1 1 
ATOM   1945 N NE2 . GLN A 1 266 ? -5.002  -47.479 -30.398 1.00 105.06 ? 278 GLN A NE2 1 
ATOM   1946 N N   . VAL A 1 267 ? -1.079  -44.875 -27.100 1.00 94.15  ? 279 VAL A N   1 
ATOM   1947 C CA  . VAL A 1 267 ? 0.216   -44.237 -26.874 1.00 90.33  ? 279 VAL A CA  1 
ATOM   1948 C C   . VAL A 1 267 ? 0.612   -44.340 -25.409 1.00 91.91  ? 279 VAL A C   1 
ATOM   1949 O O   . VAL A 1 267 ? 1.740   -44.721 -25.069 1.00 84.53  ? 279 VAL A O   1 
ATOM   1950 C CB  . VAL A 1 267 ? 0.171   -42.773 -27.324 1.00 81.58  ? 279 VAL A CB  1 
ATOM   1951 C CG1 . VAL A 1 267 ? 1.410   -42.096 -26.898 1.00 84.72  ? 279 VAL A CG1 1 
ATOM   1952 C CG2 . VAL A 1 267 ? 0.040   -42.709 -28.792 1.00 84.13  ? 279 VAL A CG2 1 
ATOM   1953 N N   . PHE A 1 268 ? -0.319  -44.007 -24.521 1.00 93.25  ? 280 PHE A N   1 
ATOM   1954 C CA  . PHE A 1 268 ? -0.008  -43.974 -23.105 1.00 86.79  ? 280 PHE A CA  1 
ATOM   1955 C C   . PHE A 1 268 ? 0.022   -45.357 -22.470 1.00 92.33  ? 280 PHE A C   1 
ATOM   1956 O O   . PHE A 1 268 ? 0.892   -45.613 -21.636 1.00 96.97  ? 280 PHE A O   1 
ATOM   1957 C CB  . PHE A 1 268 ? -0.984  -43.062 -22.384 1.00 81.65  ? 280 PHE A CB  1 
ATOM   1958 C CG  . PHE A 1 268 ? -0.640  -41.640 -22.551 1.00 85.88  ? 280 PHE A CG  1 
ATOM   1959 C CD1 . PHE A 1 268 ? 0.354   -41.071 -21.793 1.00 83.79  ? 280 PHE A CD1 1 
ATOM   1960 C CD2 . PHE A 1 268 ? -1.269  -40.879 -23.498 1.00 89.96  ? 280 PHE A CD2 1 
ATOM   1961 C CE1 . PHE A 1 268 ? 0.707   -39.775 -21.966 1.00 77.30  ? 280 PHE A CE1 1 
ATOM   1962 C CE2 . PHE A 1 268 ? -0.923  -39.571 -23.660 1.00 89.81  ? 280 PHE A CE2 1 
ATOM   1963 C CZ  . PHE A 1 268 ? 0.068   -39.023 -22.893 1.00 78.77  ? 280 PHE A CZ  1 
ATOM   1964 N N   . GLU A 1 269 ? -0.882  -46.275 -22.829 1.00 93.33  ? 281 GLU A N   1 
ATOM   1965 C CA  . GLU A 1 269 ? -0.700  -47.607 -22.266 1.00 95.26  ? 281 GLU A CA  1 
ATOM   1966 C C   . GLU A 1 269 ? 0.521   -48.305 -22.865 1.00 90.30  ? 281 GLU A C   1 
ATOM   1967 O O   . GLU A 1 269 ? 1.020   -49.270 -22.273 1.00 87.59  ? 281 GLU A O   1 
ATOM   1968 C CB  . GLU A 1 269 ? -1.942  -48.489 -22.432 1.00 101.30 ? 281 GLU A CB  1 
ATOM   1969 C CG  . GLU A 1 269 ? -1.894  -49.434 -23.634 1.00 109.88 ? 281 GLU A CG  1 
ATOM   1970 C CD  . GLU A 1 269 ? -3.236  -50.063 -23.941 1.00 102.47 ? 281 GLU A CD  1 
ATOM   1971 O OE1 . GLU A 1 269 ? -4.203  -49.771 -23.202 1.00 93.58  ? 281 GLU A OE1 1 
ATOM   1972 O OE2 . GLU A 1 269 ? -3.325  -50.804 -24.945 1.00 107.22 ? 281 GLU A OE2 1 
ATOM   1973 N N   . GLN A 1 270 ? 1.024   -47.832 -24.009 1.00 84.30  ? 282 GLN A N   1 
ATOM   1974 C CA  . GLN A 1 270 ? 2.287   -48.351 -24.522 1.00 87.65  ? 282 GLN A CA  1 
ATOM   1975 C C   . GLN A 1 270 ? 3.482   -47.843 -23.728 1.00 91.97  ? 282 GLN A C   1 
ATOM   1976 O O   . GLN A 1 270 ? 4.424   -48.596 -23.472 1.00 87.12  ? 282 GLN A O   1 
ATOM   1977 C CB  . GLN A 1 270 ? 2.463   -47.961 -25.977 1.00 88.15  ? 282 GLN A CB  1 
ATOM   1978 C CG  . GLN A 1 270 ? 3.781   -48.400 -26.551 1.00 87.81  ? 282 GLN A CG  1 
ATOM   1979 C CD  . GLN A 1 270 ? 4.184   -47.558 -27.738 1.00 88.86  ? 282 GLN A CD  1 
ATOM   1980 O OE1 . GLN A 1 270 ? 3.867   -46.361 -27.811 1.00 84.55  ? 282 GLN A OE1 1 
ATOM   1981 N NE2 . GLN A 1 270 ? 4.886   -48.176 -28.682 1.00 85.75  ? 282 GLN A NE2 1 
ATOM   1982 N N   . ILE A 1 271 ? 3.482   -46.554 -23.371 1.00 98.60  ? 283 ILE A N   1 
ATOM   1983 C CA  . ILE A 1 271 ? 4.632   -45.964 -22.691 1.00 89.97  ? 283 ILE A CA  1 
ATOM   1984 C C   . ILE A 1 271 ? 4.652   -46.315 -21.219 1.00 89.23  ? 283 ILE A C   1 
ATOM   1985 O O   . ILE A 1 271 ? 5.649   -46.031 -20.536 1.00 95.96  ? 283 ILE A O   1 
ATOM   1986 C CB  . ILE A 1 271 ? 4.636   -44.438 -22.875 1.00 90.61  ? 283 ILE A CB  1 
ATOM   1987 C CG1 . ILE A 1 271 ? 6.071   -43.929 -22.912 1.00 90.64  ? 283 ILE A CG1 1 
ATOM   1988 C CG2 . ILE A 1 271 ? 3.900   -43.762 -21.736 1.00 79.89  ? 283 ILE A CG2 1 
ATOM   1989 C CD1 . ILE A 1 271 ? 6.195   -42.562 -23.514 1.00 82.11  ? 283 ILE A CD1 1 
ATOM   1990 N N   . ARG A 1 272 ? 3.575   -46.925 -20.725 1.00 86.63  ? 284 ARG A N   1 
ATOM   1991 C CA  . ARG A 1 272 ? 3.506   -47.503 -19.396 1.00 83.28  ? 284 ARG A CA  1 
ATOM   1992 C C   . ARG A 1 272 ? 3.581   -49.018 -19.426 1.00 90.98  ? 284 ARG A C   1 
ATOM   1993 O O   . ARG A 1 272 ? 3.452   -49.646 -18.372 1.00 99.02  ? 284 ARG A O   1 
ATOM   1994 C CB  . ARG A 1 272 ? 2.228   -47.061 -18.696 1.00 79.12  ? 284 ARG A CB  1 
ATOM   1995 C CG  . ARG A 1 272 ? 2.240   -45.595 -18.393 1.00 83.58  ? 284 ARG A CG  1 
ATOM   1996 C CD  . ARG A 1 272 ? 0.898   -45.079 -17.939 1.00 77.36  ? 284 ARG A CD  1 
ATOM   1997 N NE  . ARG A 1 272 ? 0.998   -43.649 -17.672 1.00 78.94  ? 284 ARG A NE  1 
ATOM   1998 C CZ  . ARG A 1 272 ? 0.071   -42.919 -17.061 1.00 80.23  ? 284 ARG A CZ  1 
ATOM   1999 N NH1 . ARG A 1 272 ? -1.083  -43.441 -16.677 1.00 76.99  ? 284 ARG A NH1 1 
ATOM   2000 N NH2 . ARG A 1 272 ? 0.307   -41.625 -16.833 1.00 76.82  ? 284 ARG A NH2 1 
ATOM   2001 N N   . SER A 1 273 ? 3.800   -49.620 -20.598 1.00 89.42  ? 285 SER A N   1 
ATOM   2002 C CA  . SER A 1 273 ? 3.844   -51.072 -20.736 1.00 87.08  ? 285 SER A CA  1 
ATOM   2003 C C   . SER A 1 273 ? 5.194   -51.631 -20.289 1.00 88.52  ? 285 SER A C   1 
ATOM   2004 O O   . SER A 1 273 ? 6.212   -50.936 -20.283 1.00 87.80  ? 285 SER A O   1 
ATOM   2005 C CB  . SER A 1 273 ? 3.606   -51.490 -22.185 1.00 87.72  ? 285 SER A CB  1 
ATOM   2006 O OG  . SER A 1 273 ? 4.828   -51.542 -22.909 1.00 84.06  ? 285 SER A OG  1 
ATOM   2007 N N   . ARG A 1 274 ? 5.197   -52.922 -19.946 1.00 92.17  ? 286 ARG A N   1 
ATOM   2008 C CA  . ARG A 1 274 ? 6.426   -53.586 -19.521 1.00 89.86  ? 286 ARG A CA  1 
ATOM   2009 C C   . ARG A 1 274 ? 7.459   -53.540 -20.644 1.00 88.50  ? 286 ARG A C   1 
ATOM   2010 O O   . ARG A 1 274 ? 7.120   -53.653 -21.825 1.00 93.41  ? 286 ARG A O   1 
ATOM   2011 C CB  . ARG A 1 274 ? 6.139   -55.037 -19.103 1.00 80.76  ? 286 ARG A CB  1 
ATOM   2012 C CG  . ARG A 1 274 ? 5.162   -55.185 -17.921 1.00 80.91  ? 286 ARG A CG  1 
ATOM   2013 C CD  . ARG A 1 274 ? 5.362   -56.503 -17.158 1.00 81.70  ? 286 ARG A CD  1 
ATOM   2014 N NE  . ARG A 1 274 ? 4.335   -56.764 -16.146 1.00 82.49  ? 286 ARG A NE  1 
ATOM   2015 C CZ  . ARG A 1 274 ? 4.361   -57.761 -15.263 1.00 81.90  ? 286 ARG A CZ  1 
ATOM   2016 N NH1 . ARG A 1 274 ? 5.387   -58.591 -15.174 1.00 78.43  ? 286 ARG A NH1 1 
ATOM   2017 N NH2 . ARG A 1 274 ? 3.331   -57.923 -14.437 1.00 84.80  ? 286 ARG A NH2 1 
ATOM   2018 N N   . GLY A 1 275 ? 8.721   -53.328 -20.277 1.00 81.98  ? 287 GLY A N   1 
ATOM   2019 C CA  . GLY A 1 275 ? 9.787   -53.280 -21.253 1.00 82.81  ? 287 GLY A CA  1 
ATOM   2020 C C   . GLY A 1 275 ? 9.823   -52.050 -22.137 1.00 89.02  ? 287 GLY A C   1 
ATOM   2021 O O   . GLY A 1 275 ? 10.630  -52.013 -23.078 1.00 87.84  ? 287 GLY A O   1 
ATOM   2022 N N   . PHE A 1 276 ? 8.981   -51.044 -21.885 1.00 90.54  ? 288 PHE A N   1 
ATOM   2023 C CA  . PHE A 1 276 ? 9.039   -49.791 -22.641 1.00 86.95  ? 288 PHE A CA  1 
ATOM   2024 C C   . PHE A 1 276 ? 9.857   -48.764 -21.868 1.00 80.77  ? 288 PHE A C   1 
ATOM   2025 O O   . PHE A 1 276 ? 9.329   -47.813 -21.283 1.00 80.42  ? 288 PHE A O   1 
ATOM   2026 C CB  . PHE A 1 276 ? 7.638   -49.265 -22.932 1.00 94.02  ? 288 PHE A CB  1 
ATOM   2027 C CG  . PHE A 1 276 ? 7.584   -48.349 -24.120 1.00 92.32  ? 288 PHE A CG  1 
ATOM   2028 C CD1 . PHE A 1 276 ? 7.688   -48.864 -25.411 1.00 86.28  ? 288 PHE A CD1 1 
ATOM   2029 C CD2 . PHE A 1 276 ? 7.478   -46.984 -23.948 1.00 86.94  ? 288 PHE A CD2 1 
ATOM   2030 C CE1 . PHE A 1 276 ? 7.666   -48.038 -26.496 1.00 81.58  ? 288 PHE A CE1 1 
ATOM   2031 C CE2 . PHE A 1 276 ? 7.448   -46.153 -25.026 1.00 87.19  ? 288 PHE A CE2 1 
ATOM   2032 C CZ  . PHE A 1 276 ? 7.548   -46.676 -26.304 1.00 88.99  ? 288 PHE A CZ  1 
ATOM   2033 N N   . CYS A 1 277 ? 11.170  -48.990 -21.880 1.00 81.01  ? 289 CYS A N   1 
ATOM   2034 C CA  . CYS A 1 277 ? 12.127  -48.200 -21.130 1.00 79.94  ? 289 CYS A CA  1 
ATOM   2035 C C   . CYS A 1 277 ? 12.878  -47.280 -22.073 1.00 84.30  ? 289 CYS A C   1 
ATOM   2036 O O   . CYS A 1 277 ? 12.635  -47.276 -23.277 1.00 88.88  ? 289 CYS A O   1 
ATOM   2037 C CB  . CYS A 1 277 ? 13.086  -49.102 -20.373 1.00 81.97  ? 289 CYS A CB  1 
ATOM   2038 S SG  . CYS A 1 277 ? 12.263  -50.144 -19.235 1.00 89.80  ? 289 CYS A SG  1 
ATOM   2039 N N   . LEU A 1 278 ? 13.816  -46.499 -21.514 1.00 84.25  ? 290 LEU A N   1 
ATOM   2040 C CA  . LEU A 1 278 ? 14.546  -45.462 -22.245 1.00 82.81  ? 290 LEU A CA  1 
ATOM   2041 C C   . LEU A 1 278 ? 14.808  -45.820 -23.706 1.00 80.60  ? 290 LEU A C   1 
ATOM   2042 O O   . LEU A 1 278 ? 14.502  -45.006 -24.577 1.00 82.34  ? 290 LEU A O   1 
ATOM   2043 C CB  . LEU A 1 278 ? 15.888  -45.132 -21.589 1.00 86.20  ? 290 LEU A CB  1 
ATOM   2044 C CG  . LEU A 1 278 ? 16.631  -43.950 -22.251 1.00 81.08  ? 290 LEU A CG  1 
ATOM   2045 C CD1 . LEU A 1 278 ? 15.698  -42.835 -22.681 1.00 80.95  ? 290 LEU A CD1 1 
ATOM   2046 C CD2 . LEU A 1 278 ? 17.792  -43.415 -21.432 1.00 83.90  ? 290 LEU A CD2 1 
ATOM   2047 N N   . PRO A 1 279 ? 15.361  -46.994 -24.037 1.00 81.29  ? 291 PRO A N   1 
ATOM   2048 C CA  . PRO A 1 279 ? 15.672  -47.239 -25.456 1.00 79.71  ? 291 PRO A CA  1 
ATOM   2049 C C   . PRO A 1 279 ? 14.431  -47.182 -26.302 1.00 79.93  ? 291 PRO A C   1 
ATOM   2050 O O   . PRO A 1 279 ? 14.442  -46.605 -27.396 1.00 73.68  ? 291 PRO A O   1 
ATOM   2051 C CB  . PRO A 1 279 ? 16.262  -48.651 -25.453 1.00 83.50  ? 291 PRO A CB  1 
ATOM   2052 C CG  . PRO A 1 279 ? 16.725  -48.865 -24.098 1.00 91.60  ? 291 PRO A CG  1 
ATOM   2053 C CD  . PRO A 1 279 ? 15.775  -48.132 -23.198 1.00 85.47  ? 291 PRO A CD  1 
ATOM   2054 N N   . SER A 1 280 ? 13.351  -47.787 -25.791 1.00 85.80  ? 292 SER A N   1 
ATOM   2055 C CA  . SER A 1 280 ? 12.040  -47.710 -26.422 1.00 82.02  ? 292 SER A CA  1 
ATOM   2056 C C   . SER A 1 280 ? 11.625  -46.258 -26.582 1.00 81.72  ? 292 SER A C   1 
ATOM   2057 O O   . SER A 1 280 ? 11.528  -45.740 -27.699 1.00 85.75  ? 292 SER A O   1 
ATOM   2058 C CB  . SER A 1 280 ? 11.012  -48.466 -25.573 1.00 83.94  ? 292 SER A CB  1 
ATOM   2059 O OG  . SER A 1 280 ? 11.392  -49.798 -25.273 1.00 81.27  ? 292 SER A OG  1 
ATOM   2060 N N   . VAL A 1 281 ? 11.441  -45.574 -25.456 1.00 80.88  ? 293 VAL A N   1 
ATOM   2061 C CA  . VAL A 1 281 ? 10.918  -44.216 -25.359 1.00 81.31  ? 293 VAL A CA  1 
ATOM   2062 C C   . VAL A 1 281 ? 11.596  -43.233 -26.314 1.00 74.33  ? 293 VAL A C   1 
ATOM   2063 O O   . VAL A 1 281 ? 10.990  -42.245 -26.734 1.00 75.53  ? 293 VAL A O   1 
ATOM   2064 C CB  . VAL A 1 281 ? 11.031  -43.768 -23.896 1.00 75.58  ? 293 VAL A CB  1 
ATOM   2065 C CG1 . VAL A 1 281 ? 10.746  -42.301 -23.752 1.00 72.44  ? 293 VAL A CG1 1 
ATOM   2066 C CG2 . VAL A 1 281 ? 10.097  -44.614 -23.040 1.00 75.01  ? 293 VAL A CG2 1 
ATOM   2067 N N   . VAL A 1 282 ? 12.831  -43.519 -26.713 1.00 73.34  ? 294 VAL A N   1 
ATOM   2068 C CA  . VAL A 1 282 ? 13.524  -42.669 -27.678 1.00 74.66  ? 294 VAL A CA  1 
ATOM   2069 C C   . VAL A 1 282 ? 13.009  -42.862 -29.103 1.00 81.85  ? 294 VAL A C   1 
ATOM   2070 O O   . VAL A 1 282 ? 12.963  -41.901 -29.879 1.00 83.96  ? 294 VAL A O   1 
ATOM   2071 C CB  . VAL A 1 282 ? 15.040  -42.920 -27.614 1.00 77.89  ? 294 VAL A CB  1 
ATOM   2072 C CG1 . VAL A 1 282 ? 15.733  -42.397 -28.862 1.00 72.01  ? 294 VAL A CG1 1 
ATOM   2073 C CG2 . VAL A 1 282 ? 15.621  -42.287 -26.377 1.00 78.85  ? 294 VAL A CG2 1 
ATOM   2074 N N   . LEU A 1 283 ? 12.629  -44.081 -29.486 1.00 86.21  ? 295 LEU A N   1 
ATOM   2075 C CA  . LEU A 1 283 ? 12.289  -44.385 -30.878 1.00 90.14  ? 295 LEU A CA  1 
ATOM   2076 C C   . LEU A 1 283 ? 10.820  -44.170 -31.216 1.00 91.05  ? 295 LEU A C   1 
ATOM   2077 O O   . LEU A 1 283 ? 10.425  -44.337 -32.375 1.00 90.21  ? 295 LEU A O   1 
ATOM   2078 C CB  . LEU A 1 283 ? 12.672  -45.825 -31.196 1.00 85.14  ? 295 LEU A CB  1 
ATOM   2079 C CG  . LEU A 1 283 ? 14.005  -46.114 -30.548 1.00 83.31  ? 295 LEU A CG  1 
ATOM   2080 C CD1 . LEU A 1 283 ? 14.249  -47.569 -30.543 1.00 87.95  ? 295 LEU A CD1 1 
ATOM   2081 C CD2 . LEU A 1 283 ? 15.084  -45.384 -31.307 1.00 98.27  ? 295 LEU A CD2 1 
ATOM   2082 N N   . HIS A 1 284 ? 10.016  -43.778 -30.249 1.00 91.59  ? 296 HIS A N   1 
ATOM   2083 C CA  . HIS A 1 284 ? 8.576   -43.805 -30.367 1.00 90.05  ? 296 HIS A CA  1 
ATOM   2084 C C   . HIS A 1 284 ? 8.021   -42.389 -30.275 1.00 84.15  ? 296 HIS A C   1 
ATOM   2085 O O   . HIS A 1 284 ? 8.601   -41.513 -29.629 1.00 85.99  ? 296 HIS A O   1 
ATOM   2086 C CB  . HIS A 1 284 ? 8.028   -44.708 -29.273 1.00 89.17  ? 296 HIS A CB  1 
ATOM   2087 C CG  . HIS A 1 284 ? 8.250   -46.164 -29.548 1.00 93.44  ? 296 HIS A CG  1 
ATOM   2088 N ND1 . HIS A 1 284 ? 7.261   -46.999 -30.020 1.00 98.53  ? 296 HIS A ND1 1 
ATOM   2089 C CD2 . HIS A 1 284 ? 9.371   -46.920 -29.474 1.00 92.81  ? 296 HIS A CD2 1 
ATOM   2090 C CE1 . HIS A 1 284 ? 7.750   -48.217 -30.176 1.00 101.84 ? 296 HIS A CE1 1 
ATOM   2091 N NE2 . HIS A 1 284 ? 9.031   -48.193 -29.858 1.00 97.13  ? 296 HIS A NE2 1 
ATOM   2092 N N   . ASN A 1 285 ? 6.907   -42.160 -30.955 1.00 80.98  ? 297 ASN A N   1 
ATOM   2093 C CA  . ASN A 1 285 ? 6.204   -40.891 -30.894 1.00 80.30  ? 297 ASN A CA  1 
ATOM   2094 C C   . ASN A 1 285 ? 7.045   -39.760 -31.445 1.00 77.18  ? 297 ASN A C   1 
ATOM   2095 O O   . ASN A 1 285 ? 6.756   -38.577 -31.215 1.00 77.28  ? 297 ASN A O   1 
ATOM   2096 C CB  . ASN A 1 285 ? 5.751   -40.620 -29.463 1.00 83.34  ? 297 ASN A CB  1 
ATOM   2097 C CG  . ASN A 1 285 ? 5.356   -41.898 -28.744 1.00 93.10  ? 297 ASN A CG  1 
ATOM   2098 O OD1 . ASN A 1 285 ? 4.395   -42.565 -29.130 1.00 96.83  ? 297 ASN A OD1 1 
ATOM   2099 N ND2 . ASN A 1 285 ? 6.151   -42.295 -27.751 1.00 101.33 ? 297 ASN A ND2 1 
ATOM   2100 N N   . ASN A 1 286 ? 8.071   -40.132 -32.191 1.00 74.45  ? 298 ASN A N   1 
ATOM   2101 C CA  . ASN A 1 286 ? 8.905   -39.151 -32.848 1.00 77.24  ? 298 ASN A CA  1 
ATOM   2102 C C   . ASN A 1 286 ? 8.053   -38.210 -33.677 1.00 73.79  ? 298 ASN A C   1 
ATOM   2103 O O   . ASN A 1 286 ? 7.141   -38.630 -34.389 1.00 78.69  ? 298 ASN A O   1 
ATOM   2104 C CB  . ASN A 1 286 ? 9.946   -39.853 -33.714 1.00 77.44  ? 298 ASN A CB  1 
ATOM   2105 C CG  . ASN A 1 286 ? 10.910  -40.660 -32.884 1.00 79.68  ? 298 ASN A CG  1 
ATOM   2106 O OD1 . ASN A 1 286 ? 10.802  -40.692 -31.657 1.00 79.55  ? 298 ASN A OD1 1 
ATOM   2107 N ND2 . ASN A 1 286 ? 11.863  -41.300 -33.534 1.00 79.40  ? 298 ASN A ND2 1 
ATOM   2108 N N   . PHE A 1 287 ? 8.323   -36.926 -33.529 1.00 75.50  ? 299 PHE A N   1 
ATOM   2109 C CA  . PHE A 1 287 ? 7.682   -35.888 -34.324 1.00 79.98  ? 299 PHE A CA  1 
ATOM   2110 C C   . PHE A 1 287 ? 6.186   -35.836 -34.101 1.00 75.74  ? 299 PHE A C   1 
ATOM   2111 O O   . PHE A 1 287 ? 5.438   -35.345 -34.943 1.00 75.62  ? 299 PHE A O   1 
ATOM   2112 C CB  . PHE A 1 287 ? 7.943   -36.056 -35.819 1.00 77.51  ? 299 PHE A CB  1 
ATOM   2113 C CG  . PHE A 1 287 ? 9.375   -36.163 -36.166 1.00 74.58  ? 299 PHE A CG  1 
ATOM   2114 C CD1 . PHE A 1 287 ? 10.165  -35.039 -36.201 1.00 78.11  ? 299 PHE A CD1 1 
ATOM   2115 C CD2 . PHE A 1 287 ? 9.913   -37.367 -36.560 1.00 75.67  ? 299 PHE A CD2 1 
ATOM   2116 C CE1 . PHE A 1 287 ? 11.495  -35.124 -36.536 1.00 84.91  ? 299 PHE A CE1 1 
ATOM   2117 C CE2 . PHE A 1 287 ? 11.239  -37.451 -36.924 1.00 78.00  ? 299 PHE A CE2 1 
ATOM   2118 C CZ  . PHE A 1 287 ? 12.031  -36.326 -36.910 1.00 79.45  ? 299 PHE A CZ  1 
ATOM   2119 N N   . VAL A 1 288 ? 5.698   -36.355 -32.997 1.00 76.72  ? 300 VAL A N   1 
ATOM   2120 C CA  . VAL A 1 288 ? 4.265   -36.411 -32.801 1.00 85.48  ? 300 VAL A CA  1 
ATOM   2121 C C   . VAL A 1 288 ? 3.877   -35.260 -31.895 1.00 84.43  ? 300 VAL A C   1 
ATOM   2122 O O   . VAL A 1 288 ? 4.601   -34.935 -30.946 1.00 83.88  ? 300 VAL A O   1 
ATOM   2123 C CB  . VAL A 1 288 ? 3.831   -37.774 -32.246 1.00 84.65  ? 300 VAL A CB  1 
ATOM   2124 C CG1 . VAL A 1 288 ? 2.433   -37.689 -31.690 1.00 89.82  ? 300 VAL A CG1 1 
ATOM   2125 C CG2 . VAL A 1 288 ? 3.926   -38.823 -33.364 1.00 84.37  ? 300 VAL A CG2 1 
ATOM   2126 N N   . ASP A 1 289 ? 2.769   -34.609 -32.215 1.00 78.76  ? 301 ASP A N   1 
ATOM   2127 C CA  . ASP A 1 289 ? 2.235   -33.609 -31.310 1.00 79.00  ? 301 ASP A CA  1 
ATOM   2128 C C   . ASP A 1 289 ? 1.493   -34.289 -30.196 1.00 81.57  ? 301 ASP A C   1 
ATOM   2129 O O   . ASP A 1 289 ? 0.459   -34.915 -30.422 1.00 81.43  ? 301 ASP A O   1 
ATOM   2130 C CB  . ASP A 1 289 ? 1.319   -32.611 -32.005 1.00 86.65  ? 301 ASP A CB  1 
ATOM   2131 C CG  . ASP A 1 289 ? 1.134   -31.349 -31.184 1.00 93.04  ? 301 ASP A CG  1 
ATOM   2132 O OD1 . ASP A 1 289 ? 1.228   -31.466 -29.938 1.00 98.60  ? 301 ASP A OD1 1 
ATOM   2133 O OD2 . ASP A 1 289 ? 0.954   -30.247 -31.753 1.00 92.66  ? 301 ASP A OD2 1 
ATOM   2134 N N   . VAL A 1 290 ? 2.025   -34.151 -28.993 1.00 83.88  ? 302 VAL A N   1 
ATOM   2135 C CA  . VAL A 1 290 ? 1.315   -34.633 -27.824 1.00 82.76  ? 302 VAL A CA  1 
ATOM   2136 C C   . VAL A 1 290 ? -0.123  -34.152 -27.846 1.00 86.80  ? 302 VAL A C   1 
ATOM   2137 O O   . VAL A 1 290 ? -1.053  -34.926 -27.608 1.00 91.75  ? 302 VAL A O   1 
ATOM   2138 C CB  . VAL A 1 290 ? 2.044   -34.183 -26.555 1.00 73.72  ? 302 VAL A CB  1 
ATOM   2139 C CG1 . VAL A 1 290 ? 1.235   -34.520 -25.349 1.00 74.23  ? 302 VAL A CG1 1 
ATOM   2140 C CG2 . VAL A 1 290 ? 3.381   -34.850 -26.509 1.00 78.28  ? 302 VAL A CG2 1 
ATOM   2141 N N   . PHE A 1 291 ? -0.333  -32.878 -28.167 1.00 88.61  ? 303 PHE A N   1 
ATOM   2142 C CA  . PHE A 1 291 ? -1.682  -32.335 -28.218 1.00 90.80  ? 303 PHE A CA  1 
ATOM   2143 C C   . PHE A 1 291 ? -2.617  -33.178 -29.082 1.00 94.51  ? 303 PHE A C   1 
ATOM   2144 O O   . PHE A 1 291 ? -3.834  -33.155 -28.856 1.00 96.82  ? 303 PHE A O   1 
ATOM   2145 C CB  . PHE A 1 291 ? -1.613  -30.896 -28.722 1.00 95.46  ? 303 PHE A CB  1 
ATOM   2146 C CG  . PHE A 1 291 ? -1.211  -29.898 -27.674 1.00 96.06  ? 303 PHE A CG  1 
ATOM   2147 C CD1 . PHE A 1 291 ? -1.451  -30.141 -26.338 1.00 96.72  ? 303 PHE A CD1 1 
ATOM   2148 C CD2 . PHE A 1 291 ? -0.576  -28.719 -28.032 1.00 96.46  ? 303 PHE A CD2 1 
ATOM   2149 C CE1 . PHE A 1 291 ? -1.093  -29.217 -25.380 1.00 100.88 ? 303 PHE A CE1 1 
ATOM   2150 C CE2 . PHE A 1 291 ? -0.215  -27.798 -27.081 1.00 96.92  ? 303 PHE A CE2 1 
ATOM   2151 C CZ  . PHE A 1 291 ? -0.475  -28.046 -25.752 1.00 100.20 ? 303 PHE A CZ  1 
ATOM   2152 N N   . SER A 1 292 ? -2.061  -33.888 -30.064 1.00 91.08  ? 304 SER A N   1 
ATOM   2153 C CA  . SER A 1 292 ? -2.922  -34.680 -30.978 1.00 91.90  ? 304 SER A CA  1 
ATOM   2154 C C   . SER A 1 292 ? -3.680  -35.728 -30.159 1.00 94.87  ? 304 SER A C   1 
ATOM   2155 O O   . SER A 1 292 ? -4.904  -35.855 -30.351 1.00 98.94  ? 304 SER A O   1 
ATOM   2156 C CB  . SER A 1 292 ? -2.121  -35.329 -32.071 1.00 85.80  ? 304 SER A CB  1 
ATOM   2157 O OG  . SER A 1 292 ? -1.355  -36.410 -31.561 1.00 81.39  ? 304 SER A OG  1 
ATOM   2158 N N   . LEU A 1 293 ? -2.980  -36.433 -29.269 1.00 91.11  ? 305 LEU A N   1 
ATOM   2159 C CA  . LEU A 1 293 ? -3.622  -37.531 -28.504 1.00 98.60  ? 305 LEU A CA  1 
ATOM   2160 C C   . LEU A 1 293 ? -4.754  -36.995 -27.614 1.00 100.07 ? 305 LEU A C   1 
ATOM   2161 O O   . LEU A 1 293 ? -5.803  -37.661 -27.525 1.00 104.08 ? 305 LEU A O   1 
ATOM   2162 C CB  . LEU A 1 293 ? -2.526  -38.198 -27.679 1.00 95.26  ? 305 LEU A CB  1 
ATOM   2163 C CG  . LEU A 1 293 ? -1.138  -38.231 -28.324 1.00 83.48  ? 305 LEU A CG  1 
ATOM   2164 C CD1 . LEU A 1 293 ? -0.062  -38.489 -27.286 1.00 72.02  ? 305 LEU A CD1 1 
ATOM   2165 C CD2 . LEU A 1 293 ? -1.080  -39.268 -29.430 1.00 85.08  ? 305 LEU A CD2 1 
ATOM   2166 N N   . VAL A 1 294 ? -4.541  -35.856 -26.954 1.00 93.12  ? 306 VAL A N   1 
ATOM   2167 C CA  . VAL A 1 294 ? -5.624  -35.246 -26.123 1.00 93.90  ? 306 VAL A CA  1 
ATOM   2168 C C   . VAL A 1 294 ? -6.719  -34.657 -27.026 1.00 102.31 ? 306 VAL A C   1 
ATOM   2169 O O   . VAL A 1 294 ? -6.377  -34.100 -28.087 1.00 102.40 ? 306 VAL A O   1 
ATOM   2170 C CB  . VAL A 1 294 ? -5.086  -34.200 -25.132 1.00 97.16  ? 306 VAL A CB  1 
ATOM   2171 C CG1 . VAL A 1 294 ? -4.159  -34.850 -24.115 1.00 99.59  ? 306 VAL A CG1 1 
ATOM   2172 C CG2 . VAL A 1 294 ? -4.375  -33.063 -25.853 1.00 111.17 ? 306 VAL A CG2 1 
ATOM   2173 N N   . ASN A 1 295 ? -7.983  -34.774 -26.616 1.00 104.55 ? 307 ASN A N   1 
ATOM   2174 C CA  . ASN A 1 295 ? -9.103  -34.158 -27.385 1.00 97.71  ? 307 ASN A CA  1 
ATOM   2175 C C   . ASN A 1 295 ? -8.962  -32.627 -27.389 1.00 96.80  ? 307 ASN A C   1 
ATOM   2176 O O   . ASN A 1 295 ? -9.242  -32.024 -28.444 1.00 101.15 ? 307 ASN A O   1 
ATOM   2177 C CB  . ASN A 1 295 ? -10.456 -34.723 -26.951 1.00 95.56  ? 307 ASN A CB  1 
ATOM   2178 C CG  . ASN A 1 295 ? -10.978 -34.155 -25.655 1.00 96.12  ? 307 ASN A CG  1 
ATOM   2179 O OD1 . ASN A 1 295 ? -10.261 -33.452 -24.937 1.00 99.21  ? 307 ASN A OD1 1 
ATOM   2180 N ND2 . ASN A 1 295 ? -12.232 -34.447 -25.339 1.00 101.56 ? 307 ASN A ND2 1 
ATOM   2181 N N   . ASP A 1 296 ? -8.550  -32.018 -26.269 1.00 97.11  ? 308 ASP A N   1 
ATOM   2182 C CA  . ASP A 1 296 ? -8.523  -30.528 -26.194 1.00 102.17 ? 308 ASP A CA  1 
ATOM   2183 C C   . ASP A 1 296 ? -7.132  -30.016 -26.567 1.00 104.46 ? 308 ASP A C   1 
ATOM   2184 O O   . ASP A 1 296 ? -6.129  -30.483 -25.989 1.00 106.44 ? 308 ASP A O   1 
ATOM   2185 C CB  . ASP A 1 296 ? -8.951  -30.025 -24.825 1.00 103.70 ? 308 ASP A CB  1 
ATOM   2186 C CG  . ASP A 1 296 ? -8.108  -30.496 -23.650 1.00 98.77  ? 308 ASP A CG  1 
ATOM   2187 O OD1 . ASP A 1 296 ? -7.385  -31.500 -23.809 1.00 112.20 ? 308 ASP A OD1 1 
ATOM   2188 O OD2 . ASP A 1 296 ? -8.196  -29.869 -22.575 1.00 100.51 ? 308 ASP A OD2 1 
ATOM   2189 N N   . THR A 1 297 ? -7.072  -29.118 -27.549 1.00 108.86 ? 309 THR A N   1 
ATOM   2190 C CA  . THR A 1 297 ? -5.744  -28.678 -28.012 1.00 107.98 ? 309 THR A CA  1 
ATOM   2191 C C   . THR A 1 297 ? -4.984  -27.951 -26.926 1.00 107.26 ? 309 THR A C   1 
ATOM   2192 O O   . THR A 1 297 ? -3.781  -28.220 -26.797 1.00 109.48 ? 309 THR A O   1 
ATOM   2193 C CB  . THR A 1 297 ? -5.928  -27.785 -29.237 1.00 106.06 ? 309 THR A CB  1 
ATOM   2194 O OG1 . THR A 1 297 ? -6.427  -26.553 -28.726 1.00 106.30 ? 309 THR A OG1 1 
ATOM   2195 C CG2 . THR A 1 297 ? -6.910  -28.369 -30.236 1.00 95.50  ? 309 THR A CG2 1 
ATOM   2196 N N   . ASN A 1 298 ? -5.619  -27.040 -26.181 1.00 104.30 ? 310 ASN A N   1 
ATOM   2197 C CA  . ASN A 1 298 ? -4.771  -26.304 -25.202 1.00 106.96 ? 310 ASN A CA  1 
ATOM   2198 C C   . ASN A 1 298 ? -4.234  -27.259 -24.136 1.00 102.49 ? 310 ASN A C   1 
ATOM   2199 O O   . ASN A 1 298 ? -3.025  -27.159 -23.845 1.00 103.21 ? 310 ASN A O   1 
ATOM   2200 C CB  . ASN A 1 298 ? -5.554  -25.167 -24.560 1.00 104.46 ? 310 ASN A CB  1 
ATOM   2201 C CG  . ASN A 1 298 ? -6.890  -24.945 -25.227 1.00 105.21 ? 310 ASN A CG  1 
ATOM   2202 O OD1 . ASN A 1 298 ? -6.957  -24.789 -26.451 1.00 116.64 ? 310 ASN A OD1 1 
ATOM   2203 N ND2 . ASN A 1 298 ? -7.960  -24.923 -24.446 1.00 99.32  ? 310 ASN A ND2 1 
ATOM   2204 N N   . LEU A 1 299 ? -5.083  -28.113 -23.555 1.00 98.68  ? 311 LEU A N   1 
ATOM   2205 C CA  . LEU A 1 299 ? -4.660  -29.198 -22.621 1.00 94.99  ? 311 LEU A CA  1 
ATOM   2206 C C   . LEU A 1 299 ? -3.987  -28.625 -21.360 1.00 95.03  ? 311 LEU A C   1 
ATOM   2207 O O   . LEU A 1 299 ? -4.574  -28.729 -20.262 1.00 92.54  ? 311 LEU A O   1 
ATOM   2208 C CB  . LEU A 1 299 ? -3.769  -30.230 -23.310 1.00 89.99  ? 311 LEU A CB  1 
ATOM   2209 C CG  . LEU A 1 299 ? -3.225  -31.346 -22.412 1.00 93.54  ? 311 LEU A CG  1 
ATOM   2210 C CD1 . LEU A 1 299 ? -4.337  -32.203 -21.837 1.00 99.65  ? 311 LEU A CD1 1 
ATOM   2211 C CD2 . LEU A 1 299 ? -2.173  -32.207 -23.095 1.00 85.75  ? 311 LEU A CD2 1 
ATOM   2212 N N   . LEU A 1 300 ? -2.807  -28.022 -21.538 1.00 96.31  ? 312 LEU A N   1 
ATOM   2213 C CA  . LEU A 1 300 ? -2.015  -27.479 -20.404 1.00 84.57  ? 312 LEU A CA  1 
ATOM   2214 C C   . LEU A 1 300 ? -2.725  -26.316 -19.712 1.00 84.91  ? 312 LEU A C   1 
ATOM   2215 O O   . LEU A 1 300 ? -2.736  -26.302 -18.473 1.00 89.11  ? 312 LEU A O   1 
ATOM   2216 C CB  . LEU A 1 300 ? -0.649  -27.064 -20.943 1.00 83.03  ? 312 LEU A CB  1 
ATOM   2217 C CG  . LEU A 1 300 ? 0.113   -28.153 -21.706 1.00 87.19  ? 312 LEU A CG  1 
ATOM   2218 C CD1 . LEU A 1 300 ? 1.371   -27.601 -22.350 1.00 86.73  ? 312 LEU A CD1 1 
ATOM   2219 C CD2 . LEU A 1 300 ? 0.447   -29.312 -20.784 1.00 75.70  ? 312 LEU A CD2 1 
ATOM   2220 N N   . ILE A 1 301 ? -3.342  -25.417 -20.480 1.00 92.30  ? 313 ILE A N   1 
ATOM   2221 C CA  . ILE A 1 301 ? -3.925  -24.187 -19.862 1.00 96.84  ? 313 ILE A CA  1 
ATOM   2222 C C   . ILE A 1 301 ? -5.033  -24.596 -18.878 1.00 90.75  ? 313 ILE A C   1 
ATOM   2223 O O   . ILE A 1 301 ? -5.126  -23.972 -17.803 1.00 91.63  ? 313 ILE A O   1 
ATOM   2224 C CB  . ILE A 1 301 ? -4.389  -23.188 -20.942 1.00 98.06  ? 313 ILE A CB  1 
ATOM   2225 C CG1 . ILE A 1 301 ? -5.477  -23.754 -21.857 1.00 96.27  ? 313 ILE A CG1 1 
ATOM   2226 C CG2 . ILE A 1 301 ? -3.193  -22.672 -21.743 1.00 92.53  ? 313 ILE A CG2 1 
ATOM   2227 C CD1 . ILE A 1 301 ? -6.101  -22.729 -22.783 1.00 92.53  ? 313 ILE A CD1 1 
ATOM   2228 N N   . GLU A 1 302 ? -5.839  -25.595 -19.239 1.00 93.13  ? 314 GLU A N   1 
ATOM   2229 C CA  . GLU A 1 302 ? -6.930  -26.044 -18.345 1.00 91.70  ? 314 GLU A CA  1 
ATOM   2230 C C   . GLU A 1 302 ? -6.316  -26.629 -17.066 1.00 94.56  ? 314 GLU A C   1 
ATOM   2231 O O   . GLU A 1 302 ? -5.322  -27.380 -17.173 1.00 92.39  ? 314 GLU A O   1 
ATOM   2232 C CB  . GLU A 1 302 ? -7.790  -27.054 -19.104 1.00 91.52  ? 314 GLU A CB  1 
ATOM   2233 C CG  . GLU A 1 302 ? -8.414  -26.486 -20.375 1.00 87.77  ? 314 GLU A CG  1 
ATOM   2234 C CD  . GLU A 1 302 ? -7.627  -26.714 -21.654 1.00 95.57  ? 314 GLU A CD  1 
ATOM   2235 O OE1 . GLU A 1 302 ? -6.386  -26.601 -21.616 1.00 98.13  ? 314 GLU A OE1 1 
ATOM   2236 O OE2 . GLU A 1 302 ? -8.258  -26.989 -22.695 1.00 95.57  ? 314 GLU A OE2 1 
ATOM   2237 N N   . GLU A 1 303 ? -6.892  -26.307 -15.908 1.00 89.92  ? 315 GLU A N   1 
ATOM   2238 C CA  . GLU A 1 303 ? -6.421  -26.888 -14.625 1.00 90.66  ? 315 GLU A CA  1 
ATOM   2239 C C   . GLU A 1 303 ? -6.797  -28.378 -14.591 1.00 91.08  ? 315 GLU A C   1 
ATOM   2240 O O   . GLU A 1 303 ? -7.863  -28.723 -15.137 1.00 88.37  ? 315 GLU A O   1 
ATOM   2241 C CB  . GLU A 1 303 ? -7.022  -26.094 -13.466 1.00 89.31  ? 315 GLU A CB  1 
ATOM   2242 C CG  . GLU A 1 303 ? -6.313  -24.765 -13.224 1.00 93.53  ? 315 GLU A CG  1 
ATOM   2243 C CD  . GLU A 1 303 ? -4.880  -24.890 -12.739 1.00 93.83  ? 315 GLU A CD  1 
ATOM   2244 O OE1 . GLU A 1 303 ? -4.607  -25.761 -11.888 1.00 101.67 ? 315 GLU A OE1 1 
ATOM   2245 O OE2 . GLU A 1 303 ? -4.036  -24.101 -13.209 1.00 92.81  ? 315 GLU A OE2 1 
ATOM   2246 N N   . PRO A 1 304 ? -5.999  -29.269 -13.966 1.00 91.67  ? 316 PRO A N   1 
ATOM   2247 C CA  . PRO A 1 304 ? -4.994  -28.852 -13.001 1.00 93.69  ? 316 PRO A CA  1 
ATOM   2248 C C   . PRO A 1 304 ? -3.573  -28.839 -13.533 1.00 89.64  ? 316 PRO A C   1 
ATOM   2249 O O   . PRO A 1 304 ? -2.662  -28.450 -12.782 1.00 88.01  ? 316 PRO A O   1 
ATOM   2250 C CB  . PRO A 1 304 ? -5.208  -29.966 -11.974 1.00 94.40  ? 316 PRO A CB  1 
ATOM   2251 C CG  . PRO A 1 304 ? -5.414  -31.202 -12.823 1.00 86.40  ? 316 PRO A CG  1 
ATOM   2252 C CD  . PRO A 1 304 ? -6.096  -30.714 -14.093 1.00 87.77  ? 316 PRO A CD  1 
ATOM   2253 N N   . ILE A 1 305 ? -3.385  -29.192 -14.805 1.00 86.61  ? 317 ILE A N   1 
ATOM   2254 C CA  . ILE A 1 305 ? -2.002  -29.321 -15.348 1.00 84.30  ? 317 ILE A CA  1 
ATOM   2255 C C   . ILE A 1 305 ? -1.301  -27.959 -15.280 1.00 84.91  ? 317 ILE A C   1 
ATOM   2256 O O   . ILE A 1 305 ? -0.134  -27.930 -14.860 1.00 80.06  ? 317 ILE A O   1 
ATOM   2257 C CB  . ILE A 1 305 ? -2.049  -29.844 -16.794 1.00 83.83  ? 317 ILE A CB  1 
ATOM   2258 C CG1 . ILE A 1 305 ? -2.585  -31.275 -16.859 1.00 78.51  ? 317 ILE A CG1 1 
ATOM   2259 C CG2 . ILE A 1 305 ? -0.684  -29.714 -17.468 1.00 77.57  ? 317 ILE A CG2 1 
ATOM   2260 C CD1 . ILE A 1 305 ? -2.903  -31.753 -18.265 1.00 77.97  ? 317 ILE A CD1 1 
ATOM   2261 N N   . ALA A 1 306 ? -2.004  -26.876 -15.614 1.00 87.55  ? 318 ALA A N   1 
ATOM   2262 C CA  . ALA A 1 306 ? -1.345  -25.550 -15.664 1.00 90.04  ? 318 ALA A CA  1 
ATOM   2263 C C   . ALA A 1 306 ? -0.706  -25.232 -14.321 1.00 82.76  ? 318 ALA A C   1 
ATOM   2264 O O   . ALA A 1 306 ? 0.456   -24.787 -14.301 1.00 81.95  ? 318 ALA A O   1 
ATOM   2265 C CB  . ALA A 1 306 ? -2.353  -24.489 -16.024 1.00 91.51  ? 318 ALA A CB  1 
ATOM   2266 N N   . GLY A 1 307 ? -1.438  -25.464 -13.234 1.00 82.70  ? 319 GLY A N   1 
ATOM   2267 C CA  . GLY A 1 307 ? -0.939  -25.072 -11.939 1.00 80.28  ? 319 GLY A CA  1 
ATOM   2268 C C   . GLY A 1 307 ? -0.074  -26.143 -11.329 1.00 77.98  ? 319 GLY A C   1 
ATOM   2269 O O   . GLY A 1 307 ? 0.728   -25.859 -10.441 1.00 83.06  ? 319 GLY A O   1 
ATOM   2270 N N   . ILE A 1 308 ? -0.226  -27.385 -11.778 1.00 78.45  ? 320 ILE A N   1 
ATOM   2271 C CA  . ILE A 1 308 ? 0.757   -28.398 -11.419 1.00 75.67  ? 320 ILE A CA  1 
ATOM   2272 C C   . ILE A 1 308 ? 2.090   -28.071 -12.083 1.00 75.97  ? 320 ILE A C   1 
ATOM   2273 O O   . ILE A 1 308 ? 3.141   -28.066 -11.437 1.00 76.84  ? 320 ILE A O   1 
ATOM   2274 C CB  . ILE A 1 308 ? 0.252   -29.805 -11.787 1.00 70.30  ? 320 ILE A CB  1 
ATOM   2275 C CG1 . ILE A 1 308 ? -0.836  -30.274 -10.824 1.00 74.90  ? 320 ILE A CG1 1 
ATOM   2276 C CG2 . ILE A 1 308 ? 1.352   -30.780 -11.683 1.00 76.03  ? 320 ILE A CG2 1 
ATOM   2277 C CD1 . ILE A 1 308 ? -1.547  -31.497 -11.298 1.00 74.43  ? 320 ILE A CD1 1 
ATOM   2278 N N   . LEU A 1 309 ? 2.056   -27.737 -13.373 1.00 75.39  ? 321 LEU A N   1 
ATOM   2279 C CA  . LEU A 1 309 ? 3.224   -27.190 -14.050 1.00 70.69  ? 321 LEU A CA  1 
ATOM   2280 C C   . LEU A 1 309 ? 3.764   -25.957 -13.348 1.00 75.64  ? 321 LEU A C   1 
ATOM   2281 O O   . LEU A 1 309 ? 4.940   -25.612 -13.521 1.00 76.51  ? 321 LEU A O   1 
ATOM   2282 C CB  . LEU A 1 309 ? 2.861   -26.803 -15.473 1.00 77.89  ? 321 LEU A CB  1 
ATOM   2283 C CG  . LEU A 1 309 ? 2.607   -27.908 -16.470 1.00 73.92  ? 321 LEU A CG  1 
ATOM   2284 C CD1 . LEU A 1 309 ? 2.080   -27.291 -17.749 1.00 79.37  ? 321 LEU A CD1 1 
ATOM   2285 C CD2 . LEU A 1 309 ? 3.893   -28.645 -16.700 1.00 71.88  ? 321 LEU A CD2 1 
ATOM   2286 N N   . LYS A 1 310 ? 2.893   -25.234 -12.624 1.00 79.44  ? 322 LYS A N   1 
ATOM   2287 C CA  . LYS A 1 310 ? 3.306   -24.085 -11.815 1.00 81.06  ? 322 LYS A CA  1 
ATOM   2288 C C   . LYS A 1 310 ? 4.165   -24.538 -10.643 1.00 80.68  ? 322 LYS A C   1 
ATOM   2289 O O   . LYS A 1 310 ? 5.080   -23.824 -10.217 1.00 78.46  ? 322 LYS A O   1 
ATOM   2290 C CB  . LYS A 1 310 ? 2.070   -23.309 -11.312 1.00 76.08  ? 322 LYS A CB  1 
ATOM   2291 C CG  . LYS A 1 310 ? 1.364   -22.416 -12.334 1.00 74.11  ? 322 LYS A CG  1 
ATOM   2292 C CD  . LYS A 1 310 ? 2.206   -21.233 -12.678 1.00 76.97  ? 322 LYS A CD  1 
ATOM   2293 C CE  . LYS A 1 310 ? 2.158   -20.909 -14.139 1.00 83.90  ? 322 LYS A CE  1 
ATOM   2294 N NZ  . LYS A 1 310 ? 3.062   -21.887 -14.834 1.00 88.70  ? 322 LYS A NZ  1 
ATOM   2295 N N   . GLN A 1 311 ? 3.897   -25.725 -10.119 1.00 79.34  ? 323 GLN A N   1 
ATOM   2296 C CA  . GLN A 1 311 ? 4.755   -26.276 -9.089  1.00 76.03  ? 323 GLN A CA  1 
ATOM   2297 C C   . GLN A 1 311 ? 5.864   -27.160 -9.654  1.00 75.91  ? 323 GLN A C   1 
ATOM   2298 O O   . GLN A 1 311 ? 6.884   -27.348 -8.987  1.00 73.89  ? 323 GLN A O   1 
ATOM   2299 C CB  . GLN A 1 311 ? 3.912   -27.043 -8.052  1.00 75.49  ? 323 GLN A CB  1 
ATOM   2300 C CG  . GLN A 1 311 ? 2.433   -26.630 -7.957  1.00 79.55  ? 323 GLN A CG  1 
ATOM   2301 C CD  . GLN A 1 311 ? 1.605   -27.526 -7.028  1.00 87.35  ? 323 GLN A CD  1 
ATOM   2302 O OE1 . GLN A 1 311 ? 1.792   -28.740 -7.010  1.00 89.08  ? 323 GLN A OE1 1 
ATOM   2303 N NE2 . GLN A 1 311 ? 0.677   -26.925 -6.264  1.00 87.74  ? 323 GLN A NE2 1 
ATOM   2304 N N   . GLU A 1 312 ? 5.715   -27.687 -10.868 1.00 74.88  ? 324 GLU A N   1 
ATOM   2305 C CA  . GLU A 1 312 ? 6.756   -28.521 -11.460 1.00 71.02  ? 324 GLU A CA  1 
ATOM   2306 C C   . GLU A 1 312 ? 7.692   -27.652 -12.291 1.00 71.13  ? 324 GLU A C   1 
ATOM   2307 O O   . GLU A 1 312 ? 7.723   -27.693 -13.520 1.00 70.44  ? 324 GLU A O   1 
ATOM   2308 C CB  . GLU A 1 312 ? 6.143   -29.646 -12.278 1.00 73.82  ? 324 GLU A CB  1 
ATOM   2309 C CG  . GLU A 1 312 ? 5.404   -30.664 -11.419 1.00 76.32  ? 324 GLU A CG  1 
ATOM   2310 C CD  . GLU A 1 312 ? 6.323   -31.705 -10.786 1.00 79.94  ? 324 GLU A CD  1 
ATOM   2311 O OE1 . GLU A 1 312 ? 7.538   -31.715 -11.117 1.00 76.50  ? 324 GLU A OE1 1 
ATOM   2312 O OE2 . GLU A 1 312 ? 5.820   -32.490 -9.938  1.00 76.89  ? 324 GLU A OE2 1 
ATOM   2313 N N   . THR A 1 313 ? 8.470   -26.851 -11.571 1.00 72.33  ? 325 THR A N   1 
ATOM   2314 C CA  . THR A 1 313 ? 9.552   -26.068 -12.147 1.00 75.36  ? 325 THR A CA  1 
ATOM   2315 C C   . THR A 1 313 ? 10.405  -25.534 -11.008 1.00 72.03  ? 325 THR A C   1 
ATOM   2316 O O   . THR A 1 313 ? 9.889   -25.233 -9.931  1.00 69.22  ? 325 THR A O   1 
ATOM   2317 C CB  . THR A 1 313 ? 9.031   -24.912 -13.022 1.00 78.65  ? 325 THR A CB  1 
ATOM   2318 O OG1 . THR A 1 313 ? 10.128  -24.280 -13.682 1.00 74.25  ? 325 THR A OG1 1 
ATOM   2319 C CG2 . THR A 1 313 ? 8.291   -23.878 -12.202 1.00 74.47  ? 325 THR A CG2 1 
ATOM   2320 N N   . LEU A 1 314 ? 11.713  -25.466 -11.243 1.00 73.62  ? 326 LEU A N   1 
ATOM   2321 C CA  . LEU A 1 314 ? 12.644  -24.796 -10.348 1.00 74.23  ? 326 LEU A CA  1 
ATOM   2322 C C   . LEU A 1 314 ? 12.970  -23.376 -10.803 1.00 76.04  ? 326 LEU A C   1 
ATOM   2323 O O   . LEU A 1 314 ? 13.756  -22.683 -10.151 1.00 74.06  ? 326 LEU A O   1 
ATOM   2324 C CB  . LEU A 1 314 ? 13.920  -25.619 -10.220 1.00 68.60  ? 326 LEU A CB  1 
ATOM   2325 C CG  . LEU A 1 314 ? 13.730  -26.901 -9.426  1.00 72.94  ? 326 LEU A CG  1 
ATOM   2326 C CD1 . LEU A 1 314 ? 15.034  -27.662 -9.332  1.00 68.27  ? 326 LEU A CD1 1 
ATOM   2327 C CD2 . LEU A 1 314 ? 13.172  -26.606 -8.034  1.00 72.19  ? 326 LEU A CD2 1 
ATOM   2328 N N   . VAL A 1 315 ? 12.374  -22.928 -11.902 1.00 76.24  ? 327 VAL A N   1 
ATOM   2329 C CA  . VAL A 1 315 ? 12.548  -21.566 -12.384 1.00 75.31  ? 327 VAL A CA  1 
ATOM   2330 C C   . VAL A 1 315 ? 11.551  -20.668 -11.653 1.00 78.94  ? 327 VAL A C   1 
ATOM   2331 O O   . VAL A 1 315 ? 10.342  -20.755 -11.872 1.00 80.44  ? 327 VAL A O   1 
ATOM   2332 C CB  . VAL A 1 315 ? 12.364  -21.493 -13.901 1.00 77.72  ? 327 VAL A CB  1 
ATOM   2333 C CG1 . VAL A 1 315 ? 12.500  -20.074 -14.380 1.00 83.08  ? 327 VAL A CG1 1 
ATOM   2334 C CG2 . VAL A 1 315 ? 13.385  -22.388 -14.582 1.00 73.51  ? 327 VAL A CG2 1 
ATOM   2335 N N   . GLN A 1 316 ? 12.070  -19.789 -10.790 1.00 79.73  ? 328 GLN A N   1 
ATOM   2336 C CA  . GLN A 1 316 ? 11.245  -18.961 -9.916  1.00 79.32  ? 328 GLN A CA  1 
ATOM   2337 C C   . GLN A 1 316 ? 10.325  -18.034 -10.695 1.00 81.57  ? 328 GLN A C   1 
ATOM   2338 O O   . GLN A 1 316 ? 9.339   -17.545 -10.130 1.00 90.29  ? 328 GLN A O   1 
ATOM   2339 C CB  . GLN A 1 316 ? 12.142  -18.152 -8.965  1.00 81.31  ? 328 GLN A CB  1 
ATOM   2340 C CG  . GLN A 1 316 ? 11.413  -17.287 -7.940  1.00 84.57  ? 328 GLN A CG  1 
ATOM   2341 C CD  . GLN A 1 316 ? 10.512  -18.075 -7.010  1.00 85.47  ? 328 GLN A CD  1 
ATOM   2342 O OE1 . GLN A 1 316 ? 10.968  -18.595 -5.992  1.00 81.90  ? 328 GLN A OE1 1 
ATOM   2343 N NE2 . GLN A 1 316 ? 9.229   -18.176 -7.359  1.00 82.48  ? 328 GLN A NE2 1 
ATOM   2344 N N   . ALA A 1 317 ? 10.608  -17.789 -11.975 1.00 74.91  ? 329 ALA A N   1 
ATOM   2345 C CA  . ALA A 1 317 ? 9.700   -16.987 -12.792 1.00 76.98  ? 329 ALA A CA  1 
ATOM   2346 C C   . ALA A 1 317 ? 8.318   -17.631 -12.890 1.00 81.29  ? 329 ALA A C   1 
ATOM   2347 O O   . ALA A 1 317 ? 7.296   -16.980 -12.636 1.00 81.85  ? 329 ALA A O   1 
ATOM   2348 C CB  . ALA A 1 317 ? 10.296  -16.789 -14.179 1.00 78.93  ? 329 ALA A CB  1 
ATOM   2349 N N   . GLU A 1 318 ? 8.272   -18.917 -13.253 1.00 78.58  ? 330 GLU A N   1 
ATOM   2350 C CA  . GLU A 1 318 ? 7.017   -19.639 -13.412 1.00 77.63  ? 330 GLU A CA  1 
ATOM   2351 C C   . GLU A 1 318 ? 6.444   -20.126 -12.098 1.00 77.74  ? 330 GLU A C   1 
ATOM   2352 O O   . GLU A 1 318 ? 5.233   -20.326 -12.007 1.00 81.74  ? 330 GLU A O   1 
ATOM   2353 C CB  . GLU A 1 318 ? 7.206   -20.884 -14.269 1.00 84.37  ? 330 GLU A CB  1 
ATOM   2354 C CG  . GLU A 1 318 ? 8.234   -20.783 -15.351 1.00 83.67  ? 330 GLU A CG  1 
ATOM   2355 C CD  . GLU A 1 318 ? 8.578   -22.147 -15.898 1.00 86.19  ? 330 GLU A CD  1 
ATOM   2356 O OE1 . GLU A 1 318 ? 7.876   -23.138 -15.532 1.00 81.86  ? 330 GLU A OE1 1 
ATOM   2357 O OE2 . GLU A 1 318 ? 9.558   -22.208 -16.676 1.00 82.64  ? 330 GLU A OE2 1 
ATOM   2358 N N   . ALA A 1 319 ? 7.288   -20.358 -11.102 1.00 73.26  ? 331 ALA A N   1 
ATOM   2359 C CA  . ALA A 1 319 ? 6.923   -21.206 -9.980  1.00 77.12  ? 331 ALA A CA  1 
ATOM   2360 C C   . ALA A 1 319 ? 5.836   -20.573 -9.123  1.00 79.24  ? 331 ALA A C   1 
ATOM   2361 O O   . ALA A 1 319 ? 5.980   -19.439 -8.668  1.00 90.61  ? 331 ALA A O   1 
ATOM   2362 C CB  . ALA A 1 319 ? 8.159   -21.484 -9.140  1.00 79.79  ? 331 ALA A CB  1 
ATOM   2363 N N   . SER A 1 320 ? 4.760   -21.320 -8.871  1.00 73.44  ? 332 SER A N   1 
ATOM   2364 C CA  . SER A 1 320 ? 3.679   -20.839 -8.016  1.00 72.88  ? 332 SER A CA  1 
ATOM   2365 C C   . SER A 1 320 ? 4.017   -21.097 -6.557  1.00 75.52  ? 332 SER A C   1 
ATOM   2366 O O   . SER A 1 320 ? 3.139   -21.364 -5.732  1.00 82.87  ? 332 SER A O   1 
ATOM   2367 C CB  . SER A 1 320 ? 2.351   -21.500 -8.398  1.00 86.95  ? 332 SER A CB  1 
ATOM   2368 O OG  . SER A 1 320 ? 2.400   -22.916 -8.306  1.00 82.72  ? 332 SER A OG  1 
ATOM   2369 N N   . TYR A 1 321 ? 5.300   -21.005 -6.247  1.00 77.04  ? 333 TYR A N   1 
ATOM   2370 C CA  . TYR A 1 321 ? 5.866   -21.269 -4.934  1.00 77.19  ? 333 TYR A CA  1 
ATOM   2371 C C   . TYR A 1 321 ? 7.232   -20.610 -4.935  1.00 79.59  ? 333 TYR A C   1 
ATOM   2372 O O   . TYR A 1 321 ? 7.727   -20.198 -5.987  1.00 80.01  ? 333 TYR A O   1 
ATOM   2373 C CB  . TYR A 1 321 ? 5.943   -22.778 -4.653  1.00 76.69  ? 333 TYR A CB  1 
ATOM   2374 C CG  . TYR A 1 321 ? 7.121   -23.531 -5.274  1.00 75.98  ? 333 TYR A CG  1 
ATOM   2375 C CD1 . TYR A 1 321 ? 7.158   -23.836 -6.635  1.00 74.72  ? 333 TYR A CD1 1 
ATOM   2376 C CD2 . TYR A 1 321 ? 8.184   -23.954 -4.494  1.00 78.11  ? 333 TYR A CD2 1 
ATOM   2377 C CE1 . TYR A 1 321 ? 8.234   -24.533 -7.193  1.00 72.18  ? 333 TYR A CE1 1 
ATOM   2378 C CE2 . TYR A 1 321 ? 9.258   -24.650 -5.039  1.00 76.04  ? 333 TYR A CE2 1 
ATOM   2379 C CZ  . TYR A 1 321 ? 9.280   -24.939 -6.384  1.00 73.33  ? 333 TYR A CZ  1 
ATOM   2380 O OH  . TYR A 1 321 ? 10.357  -25.636 -6.902  1.00 70.71  ? 333 TYR A OH  1 
ATOM   2381 N N   . THR A 1 322 ? 7.848   -20.496 -3.763  1.00 82.23  ? 334 THR A N   1 
ATOM   2382 C CA  . THR A 1 322 ? 9.170   -19.862 -3.707  1.00 87.63  ? 334 THR A CA  1 
ATOM   2383 C C   . THR A 1 322 ? 10.252  -20.941 -3.780  1.00 76.02  ? 334 THR A C   1 
ATOM   2384 O O   . THR A 1 322 ? 10.603  -21.569 -2.781  1.00 70.52  ? 334 THR A O   1 
ATOM   2385 C CB  . THR A 1 322 ? 9.330   -18.972 -2.475  1.00 90.04  ? 334 THR A CB  1 
ATOM   2386 O OG1 . THR A 1 322 ? 8.123   -18.230 -2.236  1.00 83.33  ? 334 THR A OG1 1 
ATOM   2387 C CG2 . THR A 1 322 ? 10.461  -17.970 -2.719  1.00 87.71  ? 334 THR A CG2 1 
ATOM   2388 N N   . VAL A 1 323 ? 10.756  -21.163 -4.988  1.00 75.71  ? 335 VAL A N   1 
ATOM   2389 C CA  . VAL A 1 323 ? 11.886  -22.038 -5.278  1.00 76.05  ? 335 VAL A CA  1 
ATOM   2390 C C   . VAL A 1 323 ? 12.977  -21.846 -4.235  1.00 81.11  ? 335 VAL A C   1 
ATOM   2391 O O   . VAL A 1 323 ? 13.403  -20.709 -3.994  1.00 93.10  ? 335 VAL A O   1 
ATOM   2392 C CB  . VAL A 1 323 ? 12.439  -21.751 -6.681  1.00 75.90  ? 335 VAL A CB  1 
ATOM   2393 C CG1 . VAL A 1 323 ? 13.723  -22.518 -6.920  1.00 76.11  ? 335 VAL A CG1 1 
ATOM   2394 C CG2 . VAL A 1 323 ? 11.408  -22.057 -7.737  1.00 73.39  ? 335 VAL A CG2 1 
ATOM   2395 N N   . PRO A 1 324 ? 13.457  -22.901 -3.593  1.00 81.48  ? 336 PRO A N   1 
ATOM   2396 C CA  . PRO A 1 324 ? 14.562  -22.748 -2.642  1.00 83.88  ? 336 PRO A CA  1 
ATOM   2397 C C   . PRO A 1 324 ? 15.916  -22.745 -3.343  1.00 84.02  ? 336 PRO A C   1 
ATOM   2398 O O   . PRO A 1 324 ? 16.054  -23.151 -4.501  1.00 84.68  ? 336 PRO A O   1 
ATOM   2399 C CB  . PRO A 1 324 ? 14.412  -23.967 -1.725  1.00 85.91  ? 336 PRO A CB  1 
ATOM   2400 C CG  . PRO A 1 324 ? 13.035  -24.515 -2.007  1.00 86.38  ? 336 PRO A CG  1 
ATOM   2401 C CD  . PRO A 1 324 ? 12.782  -24.198 -3.440  1.00 83.85  ? 336 PRO A CD  1 
ATOM   2402 N N   . VAL A 1 325 ? 16.929  -22.286 -2.612  1.00 83.35  ? 337 VAL A N   1 
ATOM   2403 C CA  . VAL A 1 325 ? 18.202  -21.929 -3.245  1.00 93.21  ? 337 VAL A CA  1 
ATOM   2404 C C   . VAL A 1 325 ? 19.398  -22.620 -2.595  1.00 94.06  ? 337 VAL A C   1 
ATOM   2405 O O   . VAL A 1 325 ? 19.900  -22.153 -1.563  1.00 98.37  ? 337 VAL A O   1 
ATOM   2406 C CB  . VAL A 1 325 ? 18.402  -20.405 -3.227  1.00 92.37  ? 337 VAL A CB  1 
ATOM   2407 C CG1 . VAL A 1 325 ? 19.596  -19.999 -4.096  1.00 82.11  ? 337 VAL A CG1 1 
ATOM   2408 C CG2 . VAL A 1 325 ? 17.124  -19.704 -3.668  1.00 93.73  ? 337 VAL A CG2 1 
ATOM   2409 N N   . PRO A 1 326 ? 19.916  -23.694 -3.187  1.00 90.99  ? 338 PRO A N   1 
ATOM   2410 C CA  . PRO A 1 326 ? 21.057  -24.413 -2.588  1.00 92.14  ? 338 PRO A CA  1 
ATOM   2411 C C   . PRO A 1 326 ? 22.337  -23.583 -2.493  1.00 89.89  ? 338 PRO A C   1 
ATOM   2412 O O   . PRO A 1 326 ? 22.968  -23.244 -3.507  1.00 80.62  ? 338 PRO A O   1 
ATOM   2413 C CB  . PRO A 1 326 ? 21.228  -25.612 -3.529  1.00 87.45  ? 338 PRO A CB  1 
ATOM   2414 C CG  . PRO A 1 326 ? 19.855  -25.835 -4.074  1.00 85.71  ? 338 PRO A CG  1 
ATOM   2415 C CD  . PRO A 1 326 ? 19.294  -24.466 -4.275  1.00 86.33  ? 338 PRO A CD  1 
ATOM   2416 N N   . LYS A 1 327 ? 22.760  -23.327 -1.244  1.00 88.96  ? 339 LYS A N   1 
ATOM   2417 C CA  . LYS A 1 327 ? 23.960  -22.535 -0.985  1.00 91.47  ? 339 LYS A CA  1 
ATOM   2418 C C   . LYS A 1 327 ? 25.234  -23.308 -1.323  1.00 87.64  ? 339 LYS A C   1 
ATOM   2419 O O   . LYS A 1 327 ? 26.100  -22.797 -2.044  1.00 94.61  ? 339 LYS A O   1 
ATOM   2420 C CB  . LYS A 1 327 ? 23.989  -22.088 0.474   1.00 85.48  ? 339 LYS A CB  1 
ATOM   2421 C CG  . LYS A 1 327 ? 22.675  -21.504 0.998   1.00 88.91  ? 339 LYS A CG  1 
ATOM   2422 C CD  . LYS A 1 327 ? 22.010  -20.487 0.080   1.00 87.05  ? 339 LYS A CD  1 
ATOM   2423 C CE  . LYS A 1 327 ? 20.691  -20.004 0.706   1.00 96.06  ? 339 LYS A CE  1 
ATOM   2424 N NZ  . LYS A 1 327 ? 19.883  -19.139 -0.209  1.00 94.56  ? 339 LYS A NZ  1 
ATOM   2425 N N   . PHE A 1 328 ? 25.366  -24.545 -0.806  1.00 82.32  ? 340 PHE A N   1 
ATOM   2426 C CA  . PHE A 1 328 ? 26.559  -25.400 -0.886  1.00 83.36  ? 340 PHE A CA  1 
ATOM   2427 C C   . PHE A 1 328 ? 27.180  -25.443 -2.285  1.00 82.89  ? 340 PHE A C   1 
ATOM   2428 O O   . PHE A 1 328 ? 26.503  -25.111 -3.272  1.00 85.12  ? 340 PHE A O   1 
ATOM   2429 C CB  . PHE A 1 328 ? 26.211  -26.809 -0.399  1.00 80.91  ? 340 PHE A CB  1 
ATOM   2430 C CG  . PHE A 1 328 ? 25.245  -27.536 -1.273  1.00 80.48  ? 340 PHE A CG  1 
ATOM   2431 C CD1 . PHE A 1 328 ? 25.688  -28.254 -2.366  1.00 83.27  ? 340 PHE A CD1 1 
ATOM   2432 C CD2 . PHE A 1 328 ? 23.887  -27.497 -1.014  1.00 81.26  ? 340 PHE A CD2 1 
ATOM   2433 C CE1 . PHE A 1 328 ? 24.802  -28.923 -3.179  1.00 84.50  ? 340 PHE A CE1 1 
ATOM   2434 C CE2 . PHE A 1 328 ? 22.993  -28.158 -1.826  1.00 77.04  ? 340 PHE A CE2 1 
ATOM   2435 C CZ  . PHE A 1 328 ? 23.455  -28.873 -2.916  1.00 83.07  ? 340 PHE A CZ  1 
ATOM   2436 N N   . PRO A 1 329 ? 28.455  -25.815 -2.426  1.00 79.42  ? 341 PRO A N   1 
ATOM   2437 C CA  . PRO A 1 329 ? 29.135  -25.565 -3.704  1.00 78.66  ? 341 PRO A CA  1 
ATOM   2438 C C   . PRO A 1 329 ? 28.650  -26.538 -4.768  1.00 79.88  ? 341 PRO A C   1 
ATOM   2439 O O   . PRO A 1 329 ? 28.777  -27.750 -4.618  1.00 84.01  ? 341 PRO A O   1 
ATOM   2440 C CB  . PRO A 1 329 ? 30.616  -25.763 -3.377  1.00 82.12  ? 341 PRO A CB  1 
ATOM   2441 C CG  . PRO A 1 329 ? 30.676  -26.020 -1.889  1.00 82.97  ? 341 PRO A CG  1 
ATOM   2442 C CD  . PRO A 1 329 ? 29.343  -26.477 -1.462  1.00 75.66  ? 341 PRO A CD  1 
ATOM   2443 N N   . ARG A 1 330 ? 28.068  -26.002 -5.826  1.00 73.22  ? 342 ARG A N   1 
ATOM   2444 C CA  . ARG A 1 330 ? 27.471  -26.839 -6.846  1.00 65.64  ? 342 ARG A CA  1 
ATOM   2445 C C   . ARG A 1 330 ? 28.223  -26.654 -8.147  1.00 71.86  ? 342 ARG A C   1 
ATOM   2446 O O   . ARG A 1 330 ? 28.980  -25.698 -8.311  1.00 76.73  ? 342 ARG A O   1 
ATOM   2447 C CB  . ARG A 1 330 ? 26.000  -26.506 -7.029  1.00 68.27  ? 342 ARG A CB  1 
ATOM   2448 C CG  . ARG A 1 330 ? 25.131  -26.851 -5.846  1.00 70.22  ? 342 ARG A CG  1 
ATOM   2449 C CD  . ARG A 1 330 ? 23.678  -26.705 -6.215  1.00 64.57  ? 342 ARG A CD  1 
ATOM   2450 N NE  . ARG A 1 330 ? 23.274  -25.311 -6.304  1.00 71.37  ? 342 ARG A NE  1 
ATOM   2451 C CZ  . ARG A 1 330 ? 22.103  -24.906 -6.775  1.00 77.76  ? 342 ARG A CZ  1 
ATOM   2452 N NH1 . ARG A 1 330 ? 21.234  -25.757 -7.288  1.00 88.95  ? 342 ARG A NH1 1 
ATOM   2453 N NH2 . ARG A 1 330 ? 21.799  -23.614 -6.744  1.00 77.43  ? 342 ARG A NH2 1 
ATOM   2454 N N   . PHE A 1 331 ? 28.004  -27.594 -9.066  1.00 75.92  ? 343 PHE A N   1 
ATOM   2455 C CA  . PHE A 1 331 ? 28.692  -27.638 -10.360 1.00 79.04  ? 343 PHE A CA  1 
ATOM   2456 C C   . PHE A 1 331 ? 27.720  -28.087 -11.439 1.00 80.19  ? 343 PHE A C   1 
ATOM   2457 O O   . PHE A 1 331 ? 27.297  -29.247 -11.449 1.00 81.36  ? 343 PHE A O   1 
ATOM   2458 C CB  . PHE A 1 331 ? 29.881  -28.589 -10.321 1.00 78.05  ? 343 PHE A CB  1 
ATOM   2459 C CG  . PHE A 1 331 ? 30.645  -28.662 -11.607 1.00 80.38  ? 343 PHE A CG  1 
ATOM   2460 C CD1 . PHE A 1 331 ? 31.334  -27.573 -12.091 1.00 84.51  ? 343 PHE A CD1 1 
ATOM   2461 C CD2 . PHE A 1 331 ? 30.663  -29.822 -12.346 1.00 81.03  ? 343 PHE A CD2 1 
ATOM   2462 C CE1 . PHE A 1 331 ? 32.055  -27.663 -13.285 1.00 86.39  ? 343 PHE A CE1 1 
ATOM   2463 C CE2 . PHE A 1 331 ? 31.379  -29.902 -13.548 1.00 80.62  ? 343 PHE A CE2 1 
ATOM   2464 C CZ  . PHE A 1 331 ? 32.071  -28.821 -14.011 1.00 78.00  ? 343 PHE A CZ  1 
ATOM   2465 N N   . MET A 1 332 ? 27.402  -27.187 -12.366 1.00 77.46  ? 344 MET A N   1 
ATOM   2466 C CA  . MET A 1 332 ? 26.347  -27.408 -13.343 1.00 74.32  ? 344 MET A CA  1 
ATOM   2467 C C   . MET A 1 332 ? 26.861  -27.131 -14.744 1.00 76.74  ? 344 MET A C   1 
ATOM   2468 O O   . MET A 1 332 ? 27.563  -26.144 -14.967 1.00 75.10  ? 344 MET A O   1 
ATOM   2469 C CB  . MET A 1 332 ? 25.130  -26.547 -13.013 1.00 68.68  ? 344 MET A CB  1 
ATOM   2470 C CG  . MET A 1 332 ? 24.561  -26.885 -11.659 1.00 69.83  ? 344 MET A CG  1 
ATOM   2471 S SD  . MET A 1 332 ? 22.874  -26.296 -11.416 1.00 78.17  ? 344 MET A SD  1 
ATOM   2472 C CE  . MET A 1 332 ? 22.285  -26.257 -13.084 1.00 76.97  ? 344 MET A CE  1 
ATOM   2473 N N   . TRP A 1 333 ? 26.547  -28.023 -15.676 1.00 78.24  ? 345 TRP A N   1 
ATOM   2474 C CA  . TRP A 1 333 ? 26.904  -27.807 -17.060 1.00 76.11  ? 345 TRP A CA  1 
ATOM   2475 C C   . TRP A 1 333 ? 25.682  -28.069 -17.917 1.00 81.72  ? 345 TRP A C   1 
ATOM   2476 O O   . TRP A 1 333 ? 24.626  -28.524 -17.443 1.00 72.15  ? 345 TRP A O   1 
ATOM   2477 C CB  . TRP A 1 333 ? 28.109  -28.664 -17.498 1.00 69.49  ? 345 TRP A CB  1 
ATOM   2478 C CG  . TRP A 1 333 ? 27.976  -30.186 -17.468 1.00 76.63  ? 345 TRP A CG  1 
ATOM   2479 C CD1 . TRP A 1 333 ? 27.902  -31.020 -18.550 1.00 76.78  ? 345 TRP A CD1 1 
ATOM   2480 C CD2 . TRP A 1 333 ? 27.840  -31.033 -16.309 1.00 76.78  ? 345 TRP A CD2 1 
ATOM   2481 N NE1 . TRP A 1 333 ? 27.795  -32.327 -18.130 1.00 70.37  ? 345 TRP A NE1 1 
ATOM   2482 C CE2 . TRP A 1 333 ? 27.744  -32.354 -16.763 1.00 69.54  ? 345 TRP A CE2 1 
ATOM   2483 C CE3 . TRP A 1 333 ? 27.808  -30.798 -14.933 1.00 79.26  ? 345 TRP A CE3 1 
ATOM   2484 C CZ2 . TRP A 1 333 ? 27.613  -33.422 -15.900 1.00 71.45  ? 345 TRP A CZ2 1 
ATOM   2485 C CZ3 . TRP A 1 333 ? 27.694  -31.883 -14.072 1.00 76.48  ? 345 TRP A CZ3 1 
ATOM   2486 C CH2 . TRP A 1 333 ? 27.583  -33.166 -14.560 1.00 69.11  ? 345 TRP A CH2 1 
ATOM   2487 N N   . HIS A 1 334 ? 25.837  -27.708 -19.187 1.00 83.07  ? 346 HIS A N   1 
ATOM   2488 C CA  . HIS A 1 334 ? 24.765  -27.849 -20.153 1.00 81.15  ? 346 HIS A CA  1 
ATOM   2489 C C   . HIS A 1 334 ? 25.297  -27.553 -21.543 1.00 80.69  ? 346 HIS A C   1 
ATOM   2490 O O   . HIS A 1 334 ? 25.931  -26.522 -21.766 1.00 74.61  ? 346 HIS A O   1 
ATOM   2491 C CB  . HIS A 1 334 ? 23.601  -26.932 -19.800 1.00 73.42  ? 346 HIS A CB  1 
ATOM   2492 C CG  . HIS A 1 334 ? 22.297  -27.398 -20.347 1.00 76.47  ? 346 HIS A CG  1 
ATOM   2493 N ND1 . HIS A 1 334 ? 21.211  -27.670 -19.545 1.00 73.17  ? 346 HIS A ND1 1 
ATOM   2494 C CD2 . HIS A 1 334 ? 21.898  -27.628 -21.620 1.00 76.49  ? 346 HIS A CD2 1 
ATOM   2495 C CE1 . HIS A 1 334 ? 20.202  -28.060 -20.302 1.00 75.28  ? 346 HIS A CE1 1 
ATOM   2496 N NE2 . HIS A 1 334 ? 20.591  -28.038 -21.565 1.00 76.85  ? 346 HIS A NE2 1 
ATOM   2497 N N   . ALA A 1 335 ? 25.092  -28.484 -22.467 1.00 85.50  ? 347 ALA A N   1 
ATOM   2498 C CA  . ALA A 1 335 ? 25.380  -28.209 -23.863 1.00 78.89  ? 347 ALA A CA  1 
ATOM   2499 C C   . ALA A 1 335 ? 24.522  -27.044 -24.306 1.00 75.76  ? 347 ALA A C   1 
ATOM   2500 O O   . ALA A 1 335 ? 23.293  -27.090 -24.193 1.00 80.53  ? 347 ALA A O   1 
ATOM   2501 C CB  . ALA A 1 335 ? 25.100  -29.441 -24.720 1.00 78.79  ? 347 ALA A CB  1 
ATOM   2502 N N   . LEU A 1 336 ? 25.163  -25.977 -24.748 1.00 70.90  ? 348 LEU A N   1 
ATOM   2503 C CA  . LEU A 1 336 ? 24.405  -24.830 -25.230 1.00 72.55  ? 348 LEU A CA  1 
ATOM   2504 C C   . LEU A 1 336 ? 23.399  -25.202 -26.309 1.00 74.70  ? 348 LEU A C   1 
ATOM   2505 O O   . LEU A 1 336 ? 22.264  -24.696 -26.256 1.00 75.20  ? 348 LEU A O   1 
ATOM   2506 C CB  . LEU A 1 336 ? 25.378  -23.758 -25.730 1.00 72.06  ? 348 LEU A CB  1 
ATOM   2507 C CG  . LEU A 1 336 ? 24.711  -22.552 -26.362 1.00 63.89  ? 348 LEU A CG  1 
ATOM   2508 C CD1 . LEU A 1 336 ? 23.755  -21.958 -25.371 1.00 70.20  ? 348 LEU A CD1 1 
ATOM   2509 C CD2 . LEU A 1 336 ? 25.755  -21.580 -26.790 1.00 55.41  ? 348 LEU A CD2 1 
ATOM   2510 N N   . PRO A 1 337 ? 23.720  -26.061 -27.283 1.00 69.55  ? 349 PRO A N   1 
ATOM   2511 C CA  . PRO A 1 337 ? 22.712  -26.444 -28.268 1.00 71.70  ? 349 PRO A CA  1 
ATOM   2512 C C   . PRO A 1 337 ? 21.976  -27.722 -27.890 1.00 71.01  ? 349 PRO A C   1 
ATOM   2513 O O   . PRO A 1 337 ? 21.695  -28.569 -28.740 1.00 69.69  ? 349 PRO A O   1 
ATOM   2514 C CB  . PRO A 1 337 ? 23.543  -26.621 -29.550 1.00 70.93  ? 349 PRO A CB  1 
ATOM   2515 C CG  . PRO A 1 337 ? 24.952  -26.194 -29.201 1.00 67.34  ? 349 PRO A CG  1 
ATOM   2516 C CD  . PRO A 1 337 ? 25.052  -26.466 -27.748 1.00 68.74  ? 349 PRO A CD  1 
ATOM   2517 N N   . ASP A 1 338 ? 21.653  -27.866 -26.615 1.00 71.83  ? 350 ASP A N   1 
ATOM   2518 C CA  . ASP A 1 338 ? 21.257  -29.167 -26.111 1.00 73.05  ? 350 ASP A CA  1 
ATOM   2519 C C   . ASP A 1 338 ? 20.007  -29.633 -26.819 1.00 75.53  ? 350 ASP A C   1 
ATOM   2520 O O   . ASP A 1 338 ? 18.908  -29.224 -26.437 1.00 79.29  ? 350 ASP A O   1 
ATOM   2521 C CB  . ASP A 1 338 ? 21.006  -29.103 -24.616 1.00 75.45  ? 350 ASP A CB  1 
ATOM   2522 C CG  . ASP A 1 338 ? 20.965  -30.462 -23.992 1.00 79.32  ? 350 ASP A CG  1 
ATOM   2523 O OD1 . ASP A 1 338 ? 20.192  -31.304 -24.488 1.00 74.01  ? 350 ASP A OD1 1 
ATOM   2524 O OD2 . ASP A 1 338 ? 21.697  -30.679 -22.993 1.00 83.81  ? 350 ASP A OD2 1 
ATOM   2525 N N   . GLU A 1 339 ? 20.154  -30.496 -27.832 1.00 79.02  ? 351 GLU A N   1 
ATOM   2526 C CA  . GLU A 1 339 ? 19.034  -30.801 -28.727 1.00 74.67  ? 351 GLU A CA  1 
ATOM   2527 C C   . GLU A 1 339 ? 17.896  -31.548 -28.031 1.00 69.11  ? 351 GLU A C   1 
ATOM   2528 O O   . GLU A 1 339 ? 16.868  -31.787 -28.656 1.00 68.72  ? 351 GLU A O   1 
ATOM   2529 C CB  . GLU A 1 339 ? 19.498  -31.618 -29.942 1.00 61.09  ? 351 GLU A CB  1 
ATOM   2530 C CG  . GLU A 1 339 ? 19.754  -33.089 -29.662 1.00 69.48  ? 351 GLU A CG  1 
ATOM   2531 C CD  . GLU A 1 339 ? 21.057  -33.408 -28.981 1.00 74.84  ? 351 GLU A CD  1 
ATOM   2532 O OE1 . GLU A 1 339 ? 21.661  -32.492 -28.376 1.00 83.69  ? 351 GLU A OE1 1 
ATOM   2533 O OE2 . GLU A 1 339 ? 21.464  -34.596 -29.023 1.00 71.41  ? 351 GLU A OE2 1 
ATOM   2534 N N   . ILE A 1 340 ? 18.044  -31.914 -26.761 1.00 73.75  ? 352 ILE A N   1 
ATOM   2535 C CA  . ILE A 1 340 ? 17.041  -32.679 -26.040 1.00 69.26  ? 352 ILE A CA  1 
ATOM   2536 C C   . ILE A 1 340 ? 16.506  -31.917 -24.837 1.00 72.21  ? 352 ILE A C   1 
ATOM   2537 O O   . ILE A 1 340 ? 15.297  -31.900 -24.610 1.00 71.60  ? 352 ILE A O   1 
ATOM   2538 C CB  . ILE A 1 340 ? 17.609  -34.055 -25.616 1.00 67.57  ? 352 ILE A CB  1 
ATOM   2539 C CG1 . ILE A 1 340 ? 18.199  -34.766 -26.834 1.00 65.88  ? 352 ILE A CG1 1 
ATOM   2540 C CG2 . ILE A 1 340 ? 16.573  -34.928 -24.939 1.00 61.37  ? 352 ILE A CG2 1 
ATOM   2541 C CD1 . ILE A 1 340 ? 18.894  -36.039 -26.514 1.00 72.01  ? 352 ILE A CD1 1 
ATOM   2542 N N   . VAL A 1 341 ? 17.367  -31.252 -24.071 1.00 75.57  ? 353 VAL A N   1 
ATOM   2543 C CA  . VAL A 1 341 ? 16.952  -30.539 -22.872 1.00 73.80  ? 353 VAL A CA  1 
ATOM   2544 C C   . VAL A 1 341 ? 17.218  -29.050 -23.073 1.00 75.84  ? 353 VAL A C   1 
ATOM   2545 O O   . VAL A 1 341 ? 18.360  -28.660 -23.335 1.00 72.60  ? 353 VAL A O   1 
ATOM   2546 C CB  . VAL A 1 341 ? 17.678  -31.049 -21.617 1.00 74.62  ? 353 VAL A CB  1 
ATOM   2547 C CG1 . VAL A 1 341 ? 17.244  -30.261 -20.410 1.00 74.35  ? 353 VAL A CG1 1 
ATOM   2548 C CG2 . VAL A 1 341 ? 17.438  -32.514 -21.429 1.00 70.88  ? 353 VAL A CG2 1 
ATOM   2549 N N   . PRO A 1 342 ? 16.208  -28.178 -22.949 1.00 84.67  ? 354 PRO A N   1 
ATOM   2550 C CA  . PRO A 1 342 ? 16.391  -26.772 -23.349 1.00 77.03  ? 354 PRO A CA  1 
ATOM   2551 C C   . PRO A 1 342 ? 17.467  -26.122 -22.513 1.00 74.53  ? 354 PRO A C   1 
ATOM   2552 O O   . PRO A 1 342 ? 17.398  -26.128 -21.284 1.00 77.00  ? 354 PRO A O   1 
ATOM   2553 C CB  . PRO A 1 342 ? 15.017  -26.150 -23.086 1.00 76.83  ? 354 PRO A CB  1 
ATOM   2554 C CG  . PRO A 1 342 ? 14.454  -26.967 -21.971 1.00 80.80  ? 354 PRO A CG  1 
ATOM   2555 C CD  . PRO A 1 342 ? 14.920  -28.377 -22.251 1.00 82.12  ? 354 PRO A CD  1 
ATOM   2556 N N   . PHE A 1 343 ? 18.484  -25.580 -23.189 1.00 76.35  ? 355 PHE A N   1 
ATOM   2557 C CA  . PHE A 1 343 ? 19.563  -24.938 -22.445 1.00 79.96  ? 355 PHE A CA  1 
ATOM   2558 C C   . PHE A 1 343 ? 19.050  -23.776 -21.613 1.00 73.12  ? 355 PHE A C   1 
ATOM   2559 O O   . PHE A 1 343 ? 19.537  -23.531 -20.506 1.00 67.43  ? 355 PHE A O   1 
ATOM   2560 C CB  . PHE A 1 343 ? 20.658  -24.430 -23.375 1.00 79.42  ? 355 PHE A CB  1 
ATOM   2561 C CG  . PHE A 1 343 ? 21.637  -23.527 -22.680 1.00 79.29  ? 355 PHE A CG  1 
ATOM   2562 C CD1 . PHE A 1 343 ? 22.621  -24.048 -21.849 1.00 83.98  ? 355 PHE A CD1 1 
ATOM   2563 C CD2 . PHE A 1 343 ? 21.525  -22.153 -22.790 1.00 74.85  ? 355 PHE A CD2 1 
ATOM   2564 C CE1 . PHE A 1 343 ? 23.508  -23.212 -21.179 1.00 81.47  ? 355 PHE A CE1 1 
ATOM   2565 C CE2 . PHE A 1 343 ? 22.402  -21.320 -22.121 1.00 79.24  ? 355 PHE A CE2 1 
ATOM   2566 C CZ  . PHE A 1 343 ? 23.396  -21.851 -21.316 1.00 77.84  ? 355 PHE A CZ  1 
ATOM   2567 N N   . GLN A 1 344 ? 18.048  -23.069 -22.125 1.00 75.96  ? 356 GLN A N   1 
ATOM   2568 C CA  . GLN A 1 344 ? 17.691  -21.775 -21.555 1.00 73.50  ? 356 GLN A CA  1 
ATOM   2569 C C   . GLN A 1 344 ? 17.132  -21.883 -20.138 1.00 69.55  ? 356 GLN A C   1 
ATOM   2570 O O   . GLN A 1 344 ? 17.689  -21.260 -19.227 1.00 72.57  ? 356 GLN A O   1 
ATOM   2571 C CB  . GLN A 1 344 ? 16.748  -21.041 -22.504 1.00 77.28  ? 356 GLN A CB  1 
ATOM   2572 C CG  . GLN A 1 344 ? 16.623  -19.584 -22.184 1.00 88.64  ? 356 GLN A CG  1 
ATOM   2573 C CD  . GLN A 1 344 ? 17.982  -18.935 -21.995 1.00 89.21  ? 356 GLN A CD  1 
ATOM   2574 O OE1 . GLN A 1 344 ? 18.798  -18.887 -22.916 1.00 86.68  ? 356 GLN A OE1 1 
ATOM   2575 N NE2 . GLN A 1 344 ? 18.231  -18.429 -20.790 1.00 87.41  ? 356 GLN A NE2 1 
ATOM   2576 N N   . PRO A 1 345 ? 16.066  -22.646 -19.875 1.00 74.72  ? 357 PRO A N   1 
ATOM   2577 C CA  . PRO A 1 345 ? 15.555  -22.673 -18.495 1.00 73.09  ? 357 PRO A CA  1 
ATOM   2578 C C   . PRO A 1 345 ? 16.600  -23.090 -17.511 1.00 65.92  ? 357 PRO A C   1 
ATOM   2579 O O   . PRO A 1 345 ? 16.441  -22.826 -16.317 1.00 65.56  ? 357 PRO A O   1 
ATOM   2580 C CB  . PRO A 1 345 ? 14.397  -23.684 -18.550 1.00 78.10  ? 357 PRO A CB  1 
ATOM   2581 C CG  . PRO A 1 345 ? 14.049  -23.813 -19.991 1.00 81.66  ? 357 PRO A CG  1 
ATOM   2582 C CD  . PRO A 1 345 ? 15.361  -23.631 -20.715 1.00 83.61  ? 357 PRO A CD  1 
ATOM   2583 N N   . ALA A 1 346 ? 17.668  -23.732 -17.979 1.00 70.48  ? 358 ALA A N   1 
ATOM   2584 C CA  . ALA A 1 346 ? 18.768  -24.092 -17.095 1.00 76.08  ? 358 ALA A CA  1 
ATOM   2585 C C   . ALA A 1 346 ? 19.516  -22.845 -16.644 1.00 75.71  ? 358 ALA A C   1 
ATOM   2586 O O   . ALA A 1 346 ? 19.543  -22.513 -15.454 1.00 72.94  ? 358 ALA A O   1 
ATOM   2587 C CB  . ALA A 1 346 ? 19.704  -25.072 -17.806 1.00 73.92  ? 358 ALA A CB  1 
ATOM   2588 N N   . ALA A 1 347 ? 20.120  -22.140 -17.592 1.00 71.07  ? 359 ALA A N   1 
ATOM   2589 C CA  . ALA A 1 347 ? 20.613  -20.793 -17.379 1.00 67.36  ? 359 ALA A CA  1 
ATOM   2590 C C   . ALA A 1 347 ? 19.740  -19.991 -16.422 1.00 73.99  ? 359 ALA A C   1 
ATOM   2591 O O   . ALA A 1 347 ? 20.246  -19.477 -15.425 1.00 79.73  ? 359 ALA A O   1 
ATOM   2592 C CB  . ALA A 1 347 ? 20.709  -20.065 -18.717 1.00 67.76  ? 359 ALA A CB  1 
ATOM   2593 N N   . ASN A 1 348 ? 18.428  -19.918 -16.675 1.00 75.12  ? 360 ASN A N   1 
ATOM   2594 C CA  . ASN A 1 348 ? 17.569  -19.036 -15.885 1.00 75.87  ? 360 ASN A CA  1 
ATOM   2595 C C   . ASN A 1 348 ? 17.413  -19.508 -14.439 1.00 74.56  ? 360 ASN A C   1 
ATOM   2596 O O   . ASN A 1 348 ? 17.275  -18.673 -13.542 1.00 76.42  ? 360 ASN A O   1 
ATOM   2597 C CB  . ASN A 1 348 ? 16.194  -18.886 -16.539 1.00 79.39  ? 360 ASN A CB  1 
ATOM   2598 C CG  . ASN A 1 348 ? 16.254  -18.119 -17.851 1.00 80.76  ? 360 ASN A CG  1 
ATOM   2599 O OD1 . ASN A 1 348 ? 17.334  -17.907 -18.403 1.00 80.26  ? 360 ASN A OD1 1 
ATOM   2600 N ND2 . ASN A 1 348 ? 15.097  -17.683 -18.345 1.00 75.71  ? 360 ASN A ND2 1 
ATOM   2601 N N   . TYR A 1 349 ? 17.398  -20.819 -14.179 1.00 73.38  ? 361 TYR A N   1 
ATOM   2602 C CA  . TYR A 1 349 ? 17.485  -21.271 -12.793 1.00 72.32  ? 361 TYR A CA  1 
ATOM   2603 C C   . TYR A 1 349 ? 18.770  -20.768 -12.180 1.00 75.49  ? 361 TYR A C   1 
ATOM   2604 O O   . TYR A 1 349 ? 18.759  -20.061 -11.167 1.00 77.36  ? 361 TYR A O   1 
ATOM   2605 C CB  . TYR A 1 349 ? 17.454  -22.791 -12.714 1.00 65.54  ? 361 TYR A CB  1 
ATOM   2606 C CG  . TYR A 1 349 ? 17.673  -23.408 -11.329 1.00 66.72  ? 361 TYR A CG  1 
ATOM   2607 C CD1 . TYR A 1 349 ? 16.652  -23.413 -10.392 1.00 73.50  ? 361 TYR A CD1 1 
ATOM   2608 C CD2 . TYR A 1 349 ? 18.874  -24.045 -10.983 1.00 66.47  ? 361 TYR A CD2 1 
ATOM   2609 C CE1 . TYR A 1 349 ? 16.806  -24.023 -9.136  1.00 76.94  ? 361 TYR A CE1 1 
ATOM   2610 C CE2 . TYR A 1 349 ? 19.047  -24.651 -9.724  1.00 70.66  ? 361 TYR A CE2 1 
ATOM   2611 C CZ  . TYR A 1 349 ? 17.999  -24.635 -8.803  1.00 75.75  ? 361 TYR A CZ  1 
ATOM   2612 O OH  . TYR A 1 349 ? 18.115  -25.214 -7.550  1.00 71.97  ? 361 TYR A OH  1 
ATOM   2613 N N   . VAL A 1 350 ? 19.887  -21.101 -12.829 1.00 73.37  ? 362 VAL A N   1 
ATOM   2614 C CA  . VAL A 1 350 ? 21.215  -20.804 -12.313 1.00 70.92  ? 362 VAL A CA  1 
ATOM   2615 C C   . VAL A 1 350 ? 21.329  -19.322 -11.980 1.00 78.49  ? 362 VAL A C   1 
ATOM   2616 O O   . VAL A 1 350 ? 21.784  -18.942 -10.891 1.00 75.87  ? 362 VAL A O   1 
ATOM   2617 C CB  . VAL A 1 350 ? 22.267  -21.255 -13.340 1.00 68.66  ? 362 VAL A CB  1 
ATOM   2618 C CG1 . VAL A 1 350 ? 23.597  -20.660 -13.042 1.00 81.30  ? 362 VAL A CG1 1 
ATOM   2619 C CG2 . VAL A 1 350 ? 22.389  -22.738 -13.339 1.00 74.55  ? 362 VAL A CG2 1 
ATOM   2620 N N   . LYS A 1 351 ? 20.878  -18.462 -12.902 1.00 78.14  ? 363 LYS A N   1 
ATOM   2621 C CA  . LYS A 1 351 ? 20.965  -17.022 -12.692 1.00 74.19  ? 363 LYS A CA  1 
ATOM   2622 C C   . LYS A 1 351 ? 20.080  -16.588 -11.537 1.00 77.60  ? 363 LYS A C   1 
ATOM   2623 O O   . LYS A 1 351 ? 20.539  -15.913 -10.609 1.00 79.69  ? 363 LYS A O   1 
ATOM   2624 C CB  . LYS A 1 351 ? 20.574  -16.285 -13.966 1.00 77.24  ? 363 LYS A CB  1 
ATOM   2625 C CG  . LYS A 1 351 ? 20.379  -14.794 -13.765 1.00 84.48  ? 363 LYS A CG  1 
ATOM   2626 C CD  . LYS A 1 351 ? 19.189  -14.251 -14.549 1.00 98.53  ? 363 LYS A CD  1 
ATOM   2627 C CE  . LYS A 1 351 ? 17.928  -15.060 -14.243 1.00 94.36  ? 363 LYS A CE  1 
ATOM   2628 N NZ  . LYS A 1 351 ? 16.667  -14.301 -14.481 1.00 101.31 ? 363 LYS A NZ  1 
ATOM   2629 N N   . GLU A 1 352 ? 18.799  -16.952 -11.593 1.00 74.86  ? 364 GLU A N   1 
ATOM   2630 C CA  . GLU A 1 352 ? 17.914  -16.750 -10.462 1.00 71.09  ? 364 GLU A CA  1 
ATOM   2631 C C   . GLU A 1 352 ? 18.594  -17.147 -9.181  1.00 71.91  ? 364 GLU A C   1 
ATOM   2632 O O   . GLU A 1 352 ? 18.674  -16.368 -8.232  1.00 72.37  ? 364 GLU A O   1 
ATOM   2633 C CB  . GLU A 1 352 ? 16.668  -17.588 -10.636 1.00 72.04  ? 364 GLU A CB  1 
ATOM   2634 C CG  . GLU A 1 352 ? 15.637  -17.037 -11.546 1.00 78.55  ? 364 GLU A CG  1 
ATOM   2635 C CD  . GLU A 1 352 ? 14.457  -17.949 -11.561 1.00 80.26  ? 364 GLU A CD  1 
ATOM   2636 O OE1 . GLU A 1 352 ? 14.541  -18.982 -10.854 1.00 82.32  ? 364 GLU A OE1 1 
ATOM   2637 O OE2 . GLU A 1 352 ? 13.451  -17.629 -12.231 1.00 80.77  ? 364 GLU A OE2 1 
ATOM   2638 N N   . GLN A 1 353 ? 19.109  -18.370 -9.157  1.00 77.30  ? 365 GLN A N   1 
ATOM   2639 C CA  . GLN A 1 353 ? 19.718  -18.936 -7.963  1.00 78.22  ? 365 GLN A CA  1 
ATOM   2640 C C   . GLN A 1 353 ? 21.015  -18.240 -7.588  1.00 79.56  ? 365 GLN A C   1 
ATOM   2641 O O   . GLN A 1 353 ? 21.470  -18.377 -6.448  1.00 77.95  ? 365 GLN A O   1 
ATOM   2642 C CB  . GLN A 1 353 ? 19.977  -20.421 -8.184  1.00 73.12  ? 365 GLN A CB  1 
ATOM   2643 C CG  . GLN A 1 353 ? 18.720  -21.211 -8.346  1.00 72.39  ? 365 GLN A CG  1 
ATOM   2644 C CD  . GLN A 1 353 ? 18.333  -21.890 -7.076  1.00 84.65  ? 365 GLN A CD  1 
ATOM   2645 O OE1 . GLN A 1 353 ? 19.190  -22.370 -6.349  1.00 86.91  ? 365 GLN A OE1 1 
ATOM   2646 N NE2 . GLN A 1 353 ? 17.028  -21.977 -6.814  1.00 85.95  ? 365 GLN A NE2 1 
ATOM   2647 N N   . CYS A 1 354 ? 21.631  -17.516 -8.519  1.00 77.24  ? 366 CYS A N   1 
ATOM   2648 C CA  . CYS A 1 354 ? 22.864  -16.828 -8.189  1.00 79.31  ? 366 CYS A CA  1 
ATOM   2649 C C   . CYS A 1 354 ? 22.597  -15.480 -7.541  1.00 76.89  ? 366 CYS A C   1 
ATOM   2650 O O   . CYS A 1 354 ? 23.377  -15.063 -6.677  1.00 78.34  ? 366 CYS A O   1 
ATOM   2651 C CB  . CYS A 1 354 ? 23.728  -16.657 -9.434  1.00 82.18  ? 366 CYS A CB  1 
ATOM   2652 S SG  . CYS A 1 354 ? 24.937  -17.982 -9.757  1.00 83.85  ? 366 CYS A SG  1 
ATOM   2653 N N   . GLN A 1 355 ? 21.512  -14.789 -7.926  1.00 72.94  ? 367 GLN A N   1 
ATOM   2654 C CA  . GLN A 1 355 ? 21.136  -13.573 -7.209  1.00 77.80  ? 367 GLN A CA  1 
ATOM   2655 C C   . GLN A 1 355 ? 20.512  -13.864 -5.859  1.00 74.61  ? 367 GLN A C   1 
ATOM   2656 O O   . GLN A 1 355 ? 20.390  -12.956 -5.044  1.00 82.34  ? 367 GLN A O   1 
ATOM   2657 C CB  . GLN A 1 355 ? 20.144  -12.697 -7.977  1.00 90.64  ? 367 GLN A CB  1 
ATOM   2658 C CG  . GLN A 1 355 ? 20.366  -12.383 -9.449  1.00 89.35  ? 367 GLN A CG  1 
ATOM   2659 C CD  . GLN A 1 355 ? 19.026  -12.316 -10.184 1.00 93.75  ? 367 GLN A CD  1 
ATOM   2660 O OE1 . GLN A 1 355 ? 17.975  -12.579 -9.593  1.00 100.10 ? 367 GLN A OE1 1 
ATOM   2661 N NE2 . GLN A 1 355 ? 19.049  -11.873 -11.439 1.00 96.88  ? 367 GLN A NE2 1 
ATOM   2662 N N   . LYS A 1 356 ? 20.065  -15.075 -5.616  1.00 75.17  ? 368 LYS A N   1 
ATOM   2663 C CA  . LYS A 1 356 ? 19.676  -15.469 -4.271  1.00 80.38  ? 368 LYS A CA  1 
ATOM   2664 C C   . LYS A 1 356 ? 20.855  -16.099 -3.521  1.00 75.20  ? 368 LYS A C   1 
ATOM   2665 O O   . LYS A 1 356 ? 20.678  -16.596 -2.406  1.00 74.49  ? 368 LYS A O   1 
ATOM   2666 C CB  . LYS A 1 356 ? 18.484  -16.448 -4.322  1.00 83.94  ? 368 LYS A CB  1 
ATOM   2667 C CG  . LYS A 1 356 ? 17.103  -15.950 -4.904  1.00 83.84  ? 368 LYS A CG  1 
ATOM   2668 C CD  . LYS A 1 356 ? 16.065  -15.379 -3.894  1.00 92.20  ? 368 LYS A CD  1 
ATOM   2669 C CE  . LYS A 1 356 ? 14.603  -15.480 -4.463  1.00 93.67  ? 368 LYS A CE  1 
ATOM   2670 N NZ  . LYS A 1 356 ? 13.502  -14.735 -3.738  1.00 77.86  ? 368 LYS A NZ  1 
ATOM   2671 N N   . GLY A 1 357 ? 22.041  -16.120 -4.132  1.00 71.70  ? 369 GLY A N   1 
ATOM   2672 C CA  . GLY A 1 357 ? 23.289  -16.396 -3.444  1.00 75.34  ? 369 GLY A CA  1 
ATOM   2673 C C   . GLY A 1 357 ? 23.715  -17.843 -3.303  1.00 84.23  ? 369 GLY A C   1 
ATOM   2674 O O   . GLY A 1 357 ? 23.791  -18.346 -2.178  1.00 84.66  ? 369 GLY A O   1 
ATOM   2675 N N   . ALA A 1 358 ? 24.043  -18.503 -4.421  1.00 86.98  ? 370 ALA A N   1 
ATOM   2676 C CA  . ALA A 1 358 ? 24.439  -19.913 -4.472  1.00 84.30  ? 370 ALA A CA  1 
ATOM   2677 C C   . ALA A 1 358 ? 25.878  -20.054 -4.958  1.00 82.60  ? 370 ALA A C   1 
ATOM   2678 O O   . ALA A 1 358 ? 26.518  -19.079 -5.356  1.00 85.24  ? 370 ALA A O   1 
ATOM   2679 C CB  . ALA A 1 358 ? 23.508  -20.718 -5.384  1.00 83.39  ? 370 ALA A CB  1 
ATOM   2680 N N   . ASN A 1 359 ? 26.397  -21.283 -4.929  1.00 79.52  ? 371 ASN A N   1 
ATOM   2681 C CA  . ASN A 1 359 ? 27.812  -21.522 -5.219  1.00 80.67  ? 371 ASN A CA  1 
ATOM   2682 C C   . ASN A 1 359 ? 27.872  -22.439 -6.424  1.00 79.52  ? 371 ASN A C   1 
ATOM   2683 O O   . ASN A 1 359 ? 28.192  -23.623 -6.308  1.00 81.06  ? 371 ASN A O   1 
ATOM   2684 C CB  . ASN A 1 359 ? 28.541  -22.104 -3.969  1.00 80.49  ? 371 ASN A CB  1 
ATOM   2685 C CG  . ASN A 1 359 ? 30.047  -21.939 -4.031  1.00 80.63  ? 371 ASN A CG  1 
ATOM   2686 O OD1 . ASN A 1 359 ? 30.578  -21.400 -5.000  1.00 82.64  ? 371 ASN A OD1 1 
ATOM   2687 N ND2 . ASN A 1 359 ? 30.738  -22.335 -2.959  1.00 82.93  ? 371 ASN A ND2 1 
ATOM   2688 N N   . ILE A 1 360 ? 27.577  -21.870 -7.592  1.00 78.84  ? 372 ILE A N   1 
ATOM   2689 C CA  . ILE A 1 360 ? 27.288  -22.626 -8.803  1.00 74.08  ? 372 ILE A CA  1 
ATOM   2690 C C   . ILE A 1 360 ? 28.389  -22.353 -9.814  1.00 73.48  ? 372 ILE A C   1 
ATOM   2691 O O   . ILE A 1 360 ? 28.366  -21.337 -10.519 1.00 71.32  ? 372 ILE A O   1 
ATOM   2692 C CB  . ILE A 1 360 ? 25.935  -22.262 -9.391  1.00 68.09  ? 372 ILE A CB  1 
ATOM   2693 C CG1 . ILE A 1 360 ? 24.832  -22.695 -8.456  1.00 73.15  ? 372 ILE A CG1 1 
ATOM   2694 C CG2 . ILE A 1 360 ? 25.760  -22.954 -10.710 1.00 69.17  ? 372 ILE A CG2 1 
ATOM   2695 C CD1 . ILE A 1 360 ? 23.556  -21.940 -8.728  1.00 80.96  ? 372 ILE A CD1 1 
ATOM   2696 N N   . ASN A 1 361 ? 29.334  -23.274 -9.907  1.00 75.41  ? 373 ASN A N   1 
ATOM   2697 C CA  . ASN A 1 361 ? 30.342  -23.285 -10.962 1.00 77.34  ? 373 ASN A CA  1 
ATOM   2698 C C   . ASN A 1 361 ? 29.674  -23.747 -12.255 1.00 76.16  ? 373 ASN A C   1 
ATOM   2699 O O   . ASN A 1 361 ? 29.547  -24.945 -12.500 1.00 78.98  ? 373 ASN A O   1 
ATOM   2700 C CB  . ASN A 1 361 ? 31.482  -24.202 -10.528 1.00 79.10  ? 373 ASN A CB  1 
ATOM   2701 C CG  . ASN A 1 361 ? 32.676  -24.160 -11.447 1.00 76.69  ? 373 ASN A CG  1 
ATOM   2702 O OD1 . ASN A 1 361 ? 32.586  -23.790 -12.616 1.00 71.19  ? 373 ASN A OD1 1 
ATOM   2703 N ND2 . ASN A 1 361 ? 33.821  -24.550 -10.907 1.00 82.85  ? 373 ASN A ND2 1 
ATOM   2704 N N   . TRP A 1 362 ? 29.242  -22.795 -13.085 1.00 72.57  ? 374 TRP A N   1 
ATOM   2705 C CA  . TRP A 1 362 ? 28.429  -23.048 -14.275 1.00 73.65  ? 374 TRP A CA  1 
ATOM   2706 C C   . TRP A 1 362 ? 29.302  -23.190 -15.522 1.00 77.83  ? 374 TRP A C   1 
ATOM   2707 O O   . TRP A 1 362 ? 29.985  -22.244 -15.909 1.00 81.51  ? 374 TRP A O   1 
ATOM   2708 C CB  . TRP A 1 362 ? 27.429  -21.902 -14.450 1.00 73.32  ? 374 TRP A CB  1 
ATOM   2709 C CG  . TRP A 1 362 ? 26.456  -21.934 -15.652 1.00 79.44  ? 374 TRP A CG  1 
ATOM   2710 C CD1 . TRP A 1 362 ? 26.284  -20.943 -16.580 1.00 81.59  ? 374 TRP A CD1 1 
ATOM   2711 C CD2 . TRP A 1 362 ? 25.495  -22.958 -15.997 1.00 84.47  ? 374 TRP A CD2 1 
ATOM   2712 N NE1 . TRP A 1 362 ? 25.313  -21.291 -17.488 1.00 80.77  ? 374 TRP A NE1 1 
ATOM   2713 C CE2 . TRP A 1 362 ? 24.817  -22.524 -17.157 1.00 82.09  ? 374 TRP A CE2 1 
ATOM   2714 C CE3 . TRP A 1 362 ? 25.161  -24.205 -15.453 1.00 84.07  ? 374 TRP A CE3 1 
ATOM   2715 C CZ2 . TRP A 1 362 ? 23.824  -23.287 -17.774 1.00 80.61  ? 374 TRP A CZ2 1 
ATOM   2716 C CZ3 . TRP A 1 362 ? 24.183  -24.958 -16.069 1.00 79.05  ? 374 TRP A CZ3 1 
ATOM   2717 C CH2 . TRP A 1 362 ? 23.523  -24.494 -17.216 1.00 79.77  ? 374 TRP A CH2 1 
ATOM   2718 N N   . ASN A 1 363 ? 29.237  -24.348 -16.181 1.00 76.71  ? 375 ASN A N   1 
ATOM   2719 C CA  . ASN A 1 363 ? 30.012  -24.634 -17.390 1.00 78.70  ? 375 ASN A CA  1 
ATOM   2720 C C   . ASN A 1 363 ? 29.110  -24.805 -18.610 1.00 85.95  ? 375 ASN A C   1 
ATOM   2721 O O   . ASN A 1 363 ? 28.238  -25.684 -18.638 1.00 85.98  ? 375 ASN A O   1 
ATOM   2722 C CB  . ASN A 1 363 ? 30.863  -25.876 -17.163 1.00 81.93  ? 375 ASN A CB  1 
ATOM   2723 C CG  . ASN A 1 363 ? 31.869  -25.660 -16.087 1.00 85.37  ? 375 ASN A CG  1 
ATOM   2724 O OD1 . ASN A 1 363 ? 31.508  -25.518 -14.929 1.00 87.53  ? 375 ASN A OD1 1 
ATOM   2725 N ND2 . ASN A 1 363 ? 33.153  -25.686 -16.448 1.00 90.44  ? 375 ASN A ND2 1 
ATOM   2726 N N   . VAL A 1 364 ? 29.345  -23.992 -19.635 1.00 80.21  ? 376 VAL A N   1 
ATOM   2727 C CA  . VAL A 1 364 ? 28.516  -23.984 -20.834 1.00 75.72  ? 376 VAL A CA  1 
ATOM   2728 C C   . VAL A 1 364 ? 29.388  -24.394 -22.008 1.00 78.94  ? 376 VAL A C   1 
ATOM   2729 O O   . VAL A 1 364 ? 30.352  -23.694 -22.352 1.00 79.73  ? 376 VAL A O   1 
ATOM   2730 C CB  . VAL A 1 364 ? 27.856  -22.620 -21.074 1.00 72.46  ? 376 VAL A CB  1 
ATOM   2731 C CG1 . VAL A 1 364 ? 27.298  -22.541 -22.454 1.00 72.40  ? 376 VAL A CG1 1 
ATOM   2732 C CG2 . VAL A 1 364 ? 26.755  -22.421 -20.091 1.00 74.51  ? 376 VAL A CG2 1 
ATOM   2733 N N   . TYR A 1 365 ? 29.048  -25.537 -22.615 1.00 80.80  ? 377 TYR A N   1 
ATOM   2734 C CA  . TYR A 1 365 ? 29.766  -26.049 -23.773 1.00 78.69  ? 377 TYR A CA  1 
ATOM   2735 C C   . TYR A 1 365 ? 29.146  -25.540 -25.060 1.00 70.28  ? 377 TYR A C   1 
ATOM   2736 O O   . TYR A 1 365 ? 27.961  -25.780 -25.305 1.00 68.86  ? 377 TYR A O   1 
ATOM   2737 C CB  . TYR A 1 365 ? 29.791  -27.552 -23.767 1.00 68.54  ? 377 TYR A CB  1 
ATOM   2738 C CG  . TYR A 1 365 ? 30.600  -28.091 -22.641 1.00 71.31  ? 377 TYR A CG  1 
ATOM   2739 C CD1 . TYR A 1 365 ? 30.087  -28.179 -21.350 1.00 80.56  ? 377 TYR A CD1 1 
ATOM   2740 C CD2 . TYR A 1 365 ? 31.891  -28.517 -22.868 1.00 75.55  ? 377 TYR A CD2 1 
ATOM   2741 C CE1 . TYR A 1 365 ? 30.863  -28.695 -20.310 1.00 83.53  ? 377 TYR A CE1 1 
ATOM   2742 C CE2 . TYR A 1 365 ? 32.672  -29.025 -21.854 1.00 83.95  ? 377 TYR A CE2 1 
ATOM   2743 C CZ  . TYR A 1 365 ? 32.163  -29.117 -20.580 1.00 86.58  ? 377 TYR A CZ  1 
ATOM   2744 O OH  . TYR A 1 365 ? 32.982  -29.637 -19.603 1.00 84.82  ? 377 TYR A OH  1 
ATOM   2745 N N   . PRO A 1 366 ? 29.896  -24.895 -25.895 1.00 67.30  ? 378 PRO A N   1 
ATOM   2746 C CA  . PRO A 1 366 ? 29.300  -24.121 -26.980 1.00 74.05  ? 378 PRO A CA  1 
ATOM   2747 C C   . PRO A 1 366 ? 29.092  -24.954 -28.229 1.00 71.50  ? 378 PRO A C   1 
ATOM   2748 O O   . PRO A 1 366 ? 28.246  -24.633 -29.075 1.00 65.79  ? 378 PRO A O   1 
ATOM   2749 C CB  . PRO A 1 366 ? 30.331  -23.004 -27.192 1.00 72.36  ? 378 PRO A CB  1 
ATOM   2750 C CG  . PRO A 1 366 ? 31.625  -23.619 -26.802 1.00 67.80  ? 378 PRO A CG  1 
ATOM   2751 C CD  . PRO A 1 366 ? 31.355  -24.738 -25.833 1.00 67.61  ? 378 PRO A CD  1 
ATOM   2752 N N   . ILE A 1 367 ? 29.889  -26.019 -28.336 1.00 68.13  ? 379 ILE A N   1 
ATOM   2753 C CA  . ILE A 1 367 ? 29.880  -26.933 -29.465 1.00 63.17  ? 379 ILE A CA  1 
ATOM   2754 C C   . ILE A 1 367 ? 29.653  -28.320 -28.895 1.00 67.06  ? 379 ILE A C   1 
ATOM   2755 O O   . ILE A 1 367 ? 30.600  -29.107 -28.799 1.00 71.91  ? 379 ILE A O   1 
ATOM   2756 C CB  . ILE A 1 367 ? 31.202  -26.899 -30.258 1.00 63.95  ? 379 ILE A CB  1 
ATOM   2757 C CG1 . ILE A 1 367 ? 31.678  -25.486 -30.592 1.00 62.73  ? 379 ILE A CG1 1 
ATOM   2758 C CG2 . ILE A 1 367 ? 31.044  -27.627 -31.559 1.00 70.08  ? 379 ILE A CG2 1 
ATOM   2759 C CD1 . ILE A 1 367 ? 30.659  -24.601 -31.228 1.00 71.17  ? 379 ILE A CD1 1 
ATOM   2760 N N   . ALA A 1 368 ? 28.416  -28.626 -28.494 1.00 70.86  ? 380 ALA A N   1 
ATOM   2761 C CA  . ALA A 1 368 ? 28.095  -29.926 -27.908 1.00 73.04  ? 380 ALA A CA  1 
ATOM   2762 C C   . ALA A 1 368 ? 26.609  -30.218 -28.049 1.00 74.45  ? 380 ALA A C   1 
ATOM   2763 O O   . ALA A 1 368 ? 25.789  -29.310 -28.173 1.00 73.08  ? 380 ALA A O   1 
ATOM   2764 C CB  . ALA A 1 368 ? 28.495  -29.998 -26.428 1.00 72.40  ? 380 ALA A CB  1 
ATOM   2765 N N   . GLU A 1 369 ? 26.281  -31.506 -28.021 1.00 78.22  ? 381 GLU A N   1 
ATOM   2766 C CA  . GLU A 1 369 ? 24.923  -32.019 -28.040 1.00 71.77  ? 381 GLU A CA  1 
ATOM   2767 C C   . GLU A 1 369 ? 24.573  -32.459 -26.633 1.00 69.06  ? 381 GLU A C   1 
ATOM   2768 O O   . GLU A 1 369 ? 25.417  -32.485 -25.750 1.00 74.93  ? 381 GLU A O   1 
ATOM   2769 C CB  . GLU A 1 369 ? 24.806  -33.189 -29.023 1.00 83.04  ? 381 GLU A CB  1 
ATOM   2770 C CG  . GLU A 1 369 ? 25.038  -32.783 -30.466 1.00 80.99  ? 381 GLU A CG  1 
ATOM   2771 C CD  . GLU A 1 369 ? 23.808  -32.156 -31.078 1.00 83.35  ? 381 GLU A CD  1 
ATOM   2772 O OE1 . GLU A 1 369 ? 22.912  -32.903 -31.524 1.00 83.73  ? 381 GLU A OE1 1 
ATOM   2773 O OE2 . GLU A 1 369 ? 23.700  -30.903 -31.024 1.00 81.88  ? 381 GLU A OE2 1 
ATOM   2774 N N   . HIS A 1 370 ? 23.319  -32.823 -26.420 1.00 71.83  ? 382 HIS A N   1 
ATOM   2775 C CA  . HIS A 1 370 ? 22.976  -33.515 -25.183 1.00 74.41  ? 382 HIS A CA  1 
ATOM   2776 C C   . HIS A 1 370 ? 23.898  -34.706 -24.931 1.00 76.01  ? 382 HIS A C   1 
ATOM   2777 O O   . HIS A 1 370 ? 24.387  -34.899 -23.813 1.00 74.29  ? 382 HIS A O   1 
ATOM   2778 C CB  . HIS A 1 370 ? 21.540  -34.012 -25.227 1.00 70.76  ? 382 HIS A CB  1 
ATOM   2779 C CG  . HIS A 1 370 ? 20.950  -34.220 -23.876 1.00 70.43  ? 382 HIS A CG  1 
ATOM   2780 N ND1 . HIS A 1 370 ? 21.350  -33.498 -22.778 1.00 77.67  ? 382 HIS A ND1 1 
ATOM   2781 C CD2 . HIS A 1 370 ? 20.086  -35.151 -23.416 1.00 76.63  ? 382 HIS A CD2 1 
ATOM   2782 C CE1 . HIS A 1 370 ? 20.694  -33.916 -21.712 1.00 78.06  ? 382 HIS A CE1 1 
ATOM   2783 N NE2 . HIS A 1 370 ? 19.935  -34.934 -22.068 1.00 75.29  ? 382 HIS A NE2 1 
ATOM   2784 N N   . VAL A 1 371 ? 24.114  -35.538 -25.961 1.00 78.62  ? 383 VAL A N   1 
ATOM   2785 C CA  . VAL A 1 371 ? 24.800  -36.824 -25.805 1.00 76.25  ? 383 VAL A CA  1 
ATOM   2786 C C   . VAL A 1 371 ? 26.276  -36.624 -25.570 1.00 77.99  ? 383 VAL A C   1 
ATOM   2787 O O   . VAL A 1 371 ? 26.889  -37.312 -24.747 1.00 78.60  ? 383 VAL A O   1 
ATOM   2788 C CB  . VAL A 1 371 ? 24.574  -37.699 -27.047 1.00 78.55  ? 383 VAL A CB  1 
ATOM   2789 C CG1 . VAL A 1 371 ? 23.172  -38.214 -27.070 1.00 81.47  ? 383 VAL A CG1 1 
ATOM   2790 C CG2 . VAL A 1 371 ? 24.847  -36.882 -28.310 1.00 78.42  ? 383 VAL A CG2 1 
ATOM   2791 N N   . THR A 1 372 ? 26.874  -35.723 -26.341 1.00 78.25  ? 384 THR A N   1 
ATOM   2792 C CA  . THR A 1 372 ? 28.293  -35.448 -26.249 1.00 77.16  ? 384 THR A CA  1 
ATOM   2793 C C   . THR A 1 372 ? 28.632  -34.788 -24.925 1.00 77.88  ? 384 THR A C   1 
ATOM   2794 O O   . THR A 1 372 ? 29.571  -35.209 -24.243 1.00 78.68  ? 384 THR A O   1 
ATOM   2795 C CB  . THR A 1 372 ? 28.689  -34.590 -27.448 1.00 73.94  ? 384 THR A CB  1 
ATOM   2796 O OG1 . THR A 1 372 ? 28.186  -33.273 -27.261 1.00 73.43  ? 384 THR A OG1 1 
ATOM   2797 C CG2 . THR A 1 372 ? 28.075  -35.126 -28.712 1.00 81.46  ? 384 THR A CG2 1 
ATOM   2798 N N   . ALA A 1 373 ? 27.834  -33.798 -24.513 1.00 77.92  ? 385 ALA A N   1 
ATOM   2799 C CA  . ALA A 1 373 ? 28.144  -32.998 -23.332 1.00 75.66  ? 385 ALA A CA  1 
ATOM   2800 C C   . ALA A 1 373 ? 28.100  -33.800 -22.055 1.00 74.67  ? 385 ALA A C   1 
ATOM   2801 O O   . ALA A 1 373 ? 28.696  -33.379 -21.059 1.00 79.77  ? 385 ALA A O   1 
ATOM   2802 C CB  . ALA A 1 373 ? 27.183  -31.830 -23.197 1.00 73.43  ? 385 ALA A CB  1 
ATOM   2803 N N   . GLU A 1 374 ? 27.380  -34.916 -22.058 1.00 72.99  ? 386 GLU A N   1 
ATOM   2804 C CA  . GLU A 1 374 ? 27.422  -35.836 -20.931 1.00 76.49  ? 386 GLU A CA  1 
ATOM   2805 C C   . GLU A 1 374 ? 28.838  -36.296 -20.616 1.00 75.95  ? 386 GLU A C   1 
ATOM   2806 O O   . GLU A 1 374 ? 29.164  -36.592 -19.458 1.00 74.62  ? 386 GLU A O   1 
ATOM   2807 C CB  . GLU A 1 374 ? 26.545  -37.038 -21.237 1.00 72.73  ? 386 GLU A CB  1 
ATOM   2808 C CG  . GLU A 1 374 ? 26.728  -38.075 -20.219 1.00 78.38  ? 386 GLU A CG  1 
ATOM   2809 C CD  . GLU A 1 374 ? 25.741  -39.192 -20.300 1.00 85.32  ? 386 GLU A CD  1 
ATOM   2810 O OE1 . GLU A 1 374 ? 25.676  -39.907 -21.322 1.00 88.88  ? 386 GLU A OE1 1 
ATOM   2811 O OE2 . GLU A 1 374 ? 25.101  -39.443 -19.277 1.00 100.38 ? 386 GLU A OE2 1 
ATOM   2812 N N   . ILE A 1 375 ? 29.683  -36.375 -21.630 1.00 73.54  ? 387 ILE A N   1 
ATOM   2813 C CA  . ILE A 1 375 ? 31.007  -36.961 -21.470 1.00 78.13  ? 387 ILE A CA  1 
ATOM   2814 C C   . ILE A 1 375 ? 32.032  -35.910 -21.105 1.00 82.45  ? 387 ILE A C   1 
ATOM   2815 O O   . ILE A 1 375 ? 32.861  -36.128 -20.212 1.00 84.49  ? 387 ILE A O   1 
ATOM   2816 C CB  . ILE A 1 375 ? 31.394  -37.701 -22.763 1.00 83.47  ? 387 ILE A CB  1 
ATOM   2817 C CG1 . ILE A 1 375 ? 30.402  -38.859 -22.982 1.00 77.12  ? 387 ILE A CG1 1 
ATOM   2818 C CG2 . ILE A 1 375 ? 32.858  -38.122 -22.758 1.00 82.29  ? 387 ILE A CG2 1 
ATOM   2819 C CD1 . ILE A 1 375 ? 30.064  -39.592 -21.696 1.00 67.72  ? 387 ILE A CD1 1 
ATOM   2820 N N   . PHE A 1 376 ? 31.973  -34.773 -21.803 1.00 81.90  ? 388 PHE A N   1 
ATOM   2821 C CA  . PHE A 1 376 ? 32.800  -33.616 -21.500 1.00 81.26  ? 388 PHE A CA  1 
ATOM   2822 C C   . PHE A 1 376 ? 32.881  -33.318 -20.017 1.00 77.37  ? 388 PHE A C   1 
ATOM   2823 O O   . PHE A 1 376 ? 33.916  -33.571 -19.391 1.00 76.02  ? 388 PHE A O   1 
ATOM   2824 C CB  . PHE A 1 376 ? 32.261  -32.404 -22.243 1.00 75.45  ? 388 PHE A CB  1 
ATOM   2825 C CG  . PHE A 1 376 ? 32.183  -32.584 -23.717 1.00 78.87  ? 388 PHE A CG  1 
ATOM   2826 C CD1 . PHE A 1 376 ? 32.986  -33.504 -24.362 1.00 83.86  ? 388 PHE A CD1 1 
ATOM   2827 C CD2 . PHE A 1 376 ? 31.355  -31.794 -24.482 1.00 79.81  ? 388 PHE A CD2 1 
ATOM   2828 C CE1 . PHE A 1 376 ? 32.942  -33.632 -25.744 1.00 86.63  ? 388 PHE A CE1 1 
ATOM   2829 C CE2 . PHE A 1 376 ? 31.317  -31.930 -25.870 1.00 76.86  ? 388 PHE A CE2 1 
ATOM   2830 C CZ  . PHE A 1 376 ? 32.108  -32.845 -26.492 1.00 80.52  ? 388 PHE A CZ  1 
ATOM   2831 N N   . GLY A 1 377 ? 31.790  -32.802 -19.462 1.00 71.83  ? 389 GLY A N   1 
ATOM   2832 C CA  . GLY A 1 377 ? 31.753  -32.429 -18.075 1.00 65.11  ? 389 GLY A CA  1 
ATOM   2833 C C   . GLY A 1 377 ? 31.510  -33.613 -17.179 1.00 67.90  ? 389 GLY A C   1 
ATOM   2834 O O   . GLY A 1 377 ? 30.897  -33.471 -16.118 1.00 72.26  ? 389 GLY A O   1 
ATOM   2835 N N   . LEU A 1 378 ? 31.973  -34.791 -17.594 1.00 67.51  ? 390 LEU A N   1 
ATOM   2836 C CA  . LEU A 1 378 ? 31.984  -35.927 -16.681 1.00 67.66  ? 390 LEU A CA  1 
ATOM   2837 C C   . LEU A 1 378 ? 33.210  -35.902 -15.780 1.00 73.73  ? 390 LEU A C   1 
ATOM   2838 O O   . LEU A 1 378 ? 33.086  -35.946 -14.550 1.00 70.92  ? 390 LEU A O   1 
ATOM   2839 C CB  . LEU A 1 378 ? 31.956  -37.245 -17.450 1.00 69.45  ? 390 LEU A CB  1 
ATOM   2840 C CG  . LEU A 1 378 ? 31.803  -38.340 -16.382 1.00 76.99  ? 390 LEU A CG  1 
ATOM   2841 C CD1 . LEU A 1 378 ? 30.608  -39.234 -16.660 1.00 76.02  ? 390 LEU A CD1 1 
ATOM   2842 C CD2 . LEU A 1 378 ? 33.094  -39.141 -16.075 1.00 84.22  ? 390 LEU A CD2 1 
ATOM   2843 N N   . VAL A 1 379 ? 34.397  -35.905 -16.385 1.00 76.13  ? 391 VAL A N   1 
ATOM   2844 C CA  . VAL A 1 379 ? 35.669  -35.754 -15.690 1.00 75.47  ? 391 VAL A CA  1 
ATOM   2845 C C   . VAL A 1 379 ? 35.604  -34.528 -14.786 1.00 76.69  ? 391 VAL A C   1 
ATOM   2846 O O   . VAL A 1 379 ? 35.698  -34.690 -13.555 1.00 77.09  ? 391 VAL A O   1 
ATOM   2847 C CB  . VAL A 1 379 ? 36.827  -35.733 -16.705 1.00 75.90  ? 391 VAL A CB  1 
ATOM   2848 C CG1 . VAL A 1 379 ? 38.148  -35.687 -16.015 1.00 82.90  ? 391 VAL A CG1 1 
ATOM   2849 C CG2 . VAL A 1 379 ? 36.773  -36.997 -17.537 1.00 79.09  ? 391 VAL A CG2 1 
ATOM   2850 N N   . PRO A 1 380 ? 35.421  -33.311 -15.315 1.00 68.07  ? 392 PRO A N   1 
ATOM   2851 C CA  . PRO A 1 380 ? 35.358  -32.154 -14.416 1.00 63.59  ? 392 PRO A CA  1 
ATOM   2852 C C   . PRO A 1 380 ? 34.382  -32.315 -13.273 1.00 61.40  ? 392 PRO A C   1 
ATOM   2853 O O   . PRO A 1 380 ? 34.744  -32.114 -12.115 1.00 67.91  ? 392 PRO A O   1 
ATOM   2854 C CB  . PRO A 1 380 ? 34.974  -31.017 -15.364 1.00 65.74  ? 392 PRO A CB  1 
ATOM   2855 C CG  . PRO A 1 380 ? 35.550  -31.439 -16.656 1.00 65.63  ? 392 PRO A CG  1 
ATOM   2856 C CD  . PRO A 1 380 ? 35.288  -32.886 -16.717 1.00 67.66  ? 392 PRO A CD  1 
ATOM   2857 N N   . GLY A 1 381 ? 33.166  -32.732 -13.561 1.00 62.43  ? 393 GLY A N   1 
ATOM   2858 C CA  . GLY A 1 381 ? 32.174  -32.870 -12.509 1.00 67.66  ? 393 GLY A CA  1 
ATOM   2859 C C   . GLY A 1 381 ? 32.607  -33.791 -11.397 1.00 67.93  ? 393 GLY A C   1 
ATOM   2860 O O   . GLY A 1 381 ? 32.199  -33.622 -10.244 1.00 64.60  ? 393 GLY A O   1 
ATOM   2861 N N   . LEU A 1 382 ? 33.424  -34.780 -11.729 1.00 70.67  ? 394 LEU A N   1 
ATOM   2862 C CA  . LEU A 1 382 ? 33.948  -35.699 -10.729 1.00 80.02  ? 394 LEU A CA  1 
ATOM   2863 C C   . LEU A 1 382 ? 35.192  -35.136 -10.072 1.00 73.93  ? 394 LEU A C   1 
ATOM   2864 O O   . LEU A 1 382 ? 35.324  -35.189 -8.844  1.00 73.83  ? 394 LEU A O   1 
ATOM   2865 C CB  . LEU A 1 382 ? 34.236  -37.061 -11.374 1.00 90.58  ? 394 LEU A CB  1 
ATOM   2866 C CG  . LEU A 1 382 ? 33.091  -37.953 -11.843 1.00 80.33  ? 394 LEU A CG  1 
ATOM   2867 C CD1 . LEU A 1 382 ? 33.674  -39.310 -12.161 1.00 80.54  ? 394 LEU A CD1 1 
ATOM   2868 C CD2 . LEU A 1 382 ? 32.081  -38.064 -10.720 1.00 74.56  ? 394 LEU A CD2 1 
ATOM   2869 N N   . ASP A 1 383 ? 36.106  -34.590 -10.876 1.00 74.23  ? 395 ASP A N   1 
ATOM   2870 C CA  . ASP A 1 383 ? 37.214  -33.835 -10.306 1.00 77.57  ? 395 ASP A CA  1 
ATOM   2871 C C   . ASP A 1 383 ? 36.706  -32.878 -9.248  1.00 75.36  ? 395 ASP A C   1 
ATOM   2872 O O   . ASP A 1 383 ? 37.133  -32.929 -8.088  1.00 77.12  ? 395 ASP A O   1 
ATOM   2873 C CB  . ASP A 1 383 ? 37.970  -33.060 -11.379 1.00 75.44  ? 395 ASP A CB  1 
ATOM   2874 C CG  . ASP A 1 383 ? 39.000  -32.150 -10.779 1.00 79.36  ? 395 ASP A CG  1 
ATOM   2875 O OD1 . ASP A 1 383 ? 39.808  -32.658 -9.984  1.00 80.77  ? 395 ASP A OD1 1 
ATOM   2876 O OD2 . ASP A 1 383 ? 39.014  -30.947 -11.106 1.00 78.49  ? 395 ASP A OD2 1 
ATOM   2877 N N   . PHE A 1 384 ? 35.764  -32.014 -9.647  1.00 72.41  ? 396 PHE A N   1 
ATOM   2878 C CA  . PHE A 1 384 ? 35.018  -31.198 -8.697  1.00 71.26  ? 396 PHE A CA  1 
ATOM   2879 C C   . PHE A 1 384 ? 34.502  -32.037 -7.533  1.00 73.22  ? 396 PHE A C   1 
ATOM   2880 O O   . PHE A 1 384 ? 34.720  -31.709 -6.363  1.00 77.02  ? 396 PHE A O   1 
ATOM   2881 C CB  . PHE A 1 384 ? 33.854  -30.505 -9.406  1.00 66.03  ? 396 PHE A CB  1 
ATOM   2882 C CG  . PHE A 1 384 ? 32.934  -29.732 -8.474  1.00 73.16  ? 396 PHE A CG  1 
ATOM   2883 C CD1 . PHE A 1 384 ? 32.122  -30.372 -7.538  1.00 76.82  ? 396 PHE A CD1 1 
ATOM   2884 C CD2 . PHE A 1 384 ? 32.860  -28.352 -8.557  1.00 73.24  ? 396 PHE A CD2 1 
ATOM   2885 C CE1 . PHE A 1 384 ? 31.296  -29.650 -6.691  1.00 74.87  ? 396 PHE A CE1 1 
ATOM   2886 C CE2 . PHE A 1 384 ? 32.025  -27.632 -7.716  1.00 70.85  ? 396 PHE A CE2 1 
ATOM   2887 C CZ  . PHE A 1 384 ? 31.248  -28.278 -6.789  1.00 69.30  ? 396 PHE A CZ  1 
ATOM   2888 N N   . LEU A 1 385 ? 33.770  -33.096 -7.825  1.00 71.37  ? 397 LEU A N   1 
ATOM   2889 C CA  . LEU A 1 385 ? 33.140  -33.797 -6.724  1.00 77.05  ? 397 LEU A CA  1 
ATOM   2890 C C   . LEU A 1 385 ? 34.180  -34.281 -5.726  1.00 77.70  ? 397 LEU A C   1 
ATOM   2891 O O   . LEU A 1 385 ? 33.890  -34.397 -4.526  1.00 74.93  ? 397 LEU A O   1 
ATOM   2892 C CB  . LEU A 1 385 ? 32.307  -34.953 -7.254  1.00 81.21  ? 397 LEU A CB  1 
ATOM   2893 C CG  . LEU A 1 385 ? 30.840  -34.592 -7.514  1.00 78.62  ? 397 LEU A CG  1 
ATOM   2894 C CD1 . LEU A 1 385 ? 30.026  -35.864 -7.630  1.00 83.58  ? 397 LEU A CD1 1 
ATOM   2895 C CD2 . LEU A 1 385 ? 30.238  -33.641 -6.475  1.00 77.59  ? 397 LEU A CD2 1 
ATOM   2896 N N   . SER A 1 386 ? 35.403  -34.538 -6.198  1.00 79.71  ? 398 SER A N   1 
ATOM   2897 C CA  . SER A 1 386 ? 36.489  -34.866 -5.282  1.00 84.31  ? 398 SER A CA  1 
ATOM   2898 C C   . SER A 1 386 ? 36.714  -33.718 -4.323  1.00 79.45  ? 398 SER A C   1 
ATOM   2899 O O   . SER A 1 386 ? 36.532  -33.860 -3.108  1.00 79.37  ? 398 SER A O   1 
ATOM   2900 C CB  . SER A 1 386 ? 37.778  -35.178 -6.047  1.00 84.37  ? 398 SER A CB  1 
ATOM   2901 O OG  . SER A 1 386 ? 38.793  -35.626 -5.159  1.00 89.06  ? 398 SER A OG  1 
ATOM   2902 N N   . LYS A 1 387 ? 37.067  -32.555 -4.877  1.00 74.79  ? 399 LYS A N   1 
ATOM   2903 C CA  . LYS A 1 387 ? 37.383  -31.379 -4.079  1.00 74.86  ? 399 LYS A CA  1 
ATOM   2904 C C   . LYS A 1 387 ? 36.295  -31.084 -3.049  1.00 75.75  ? 399 LYS A C   1 
ATOM   2905 O O   . LYS A 1 387 ? 36.578  -30.927 -1.860  1.00 79.57  ? 399 LYS A O   1 
ATOM   2906 C CB  . LYS A 1 387 ? 37.589  -30.178 -4.997  1.00 64.62  ? 399 LYS A CB  1 
ATOM   2907 C CG  . LYS A 1 387 ? 38.705  -30.328 -6.023  1.00 66.65  ? 399 LYS A CG  1 
ATOM   2908 C CD  . LYS A 1 387 ? 38.739  -29.078 -6.884  1.00 75.67  ? 399 LYS A CD  1 
ATOM   2909 C CE  . LYS A 1 387 ? 39.710  -29.106 -8.060  1.00 78.47  ? 399 LYS A CE  1 
ATOM   2910 N NZ  . LYS A 1 387 ? 39.533  -27.861 -8.906  1.00 70.05  ? 399 LYS A NZ  1 
ATOM   2911 N N   . ALA A 1 388 ? 35.040  -31.035 -3.478  1.00 71.02  ? 400 ALA A N   1 
ATOM   2912 C CA  . ALA A 1 388 ? 33.973  -30.692 -2.551  1.00 70.93  ? 400 ALA A CA  1 
ATOM   2913 C C   . ALA A 1 388 ? 34.021  -31.545 -1.291  1.00 76.36  ? 400 ALA A C   1 
ATOM   2914 O O   . ALA A 1 388 ? 33.767  -31.054 -0.189  1.00 78.84  ? 400 ALA A O   1 
ATOM   2915 C CB  . ALA A 1 388 ? 32.633  -30.830 -3.254  1.00 72.72  ? 400 ALA A CB  1 
ATOM   2916 N N   . PHE A 1 389 ? 34.372  -32.820 -1.432  1.00 77.56  ? 401 PHE A N   1 
ATOM   2917 C CA  . PHE A 1 389 ? 34.480  -33.698 -0.271  1.00 83.38  ? 401 PHE A CA  1 
ATOM   2918 C C   . PHE A 1 389 ? 35.621  -33.284 0.641   1.00 88.68  ? 401 PHE A C   1 
ATOM   2919 O O   . PHE A 1 389 ? 35.556  -33.492 1.864   1.00 90.07  ? 401 PHE A O   1 
ATOM   2920 C CB  . PHE A 1 389 ? 34.685  -35.133 -0.741  1.00 85.55  ? 401 PHE A CB  1 
ATOM   2921 C CG  . PHE A 1 389 ? 33.425  -35.853 -1.009  1.00 82.20  ? 401 PHE A CG  1 
ATOM   2922 C CD1 . PHE A 1 389 ? 32.321  -35.639 -0.209  1.00 83.04  ? 401 PHE A CD1 1 
ATOM   2923 C CD2 . PHE A 1 389 ? 33.312  -36.681 -2.108  1.00 80.40  ? 401 PHE A CD2 1 
ATOM   2924 C CE1 . PHE A 1 389 ? 31.137  -36.281 -0.465  1.00 81.96  ? 401 PHE A CE1 1 
ATOM   2925 C CE2 . PHE A 1 389 ? 32.136  -37.323 -2.371  1.00 81.00  ? 401 PHE A CE2 1 
ATOM   2926 C CZ  . PHE A 1 389 ? 31.041  -37.122 -1.549  1.00 80.59  ? 401 PHE A CZ  1 
ATOM   2927 N N   . LYS A 1 390 ? 36.691  -32.748 0.056   1.00 83.32  ? 402 LYS A N   1 
ATOM   2928 C CA  . LYS A 1 390 ? 37.827  -32.235 0.803   1.00 82.89  ? 402 LYS A CA  1 
ATOM   2929 C C   . LYS A 1 390 ? 37.594  -30.803 1.288   1.00 91.33  ? 402 LYS A C   1 
ATOM   2930 O O   . LYS A 1 390 ? 38.475  -30.224 1.932   1.00 89.33  ? 402 LYS A O   1 
ATOM   2931 C CB  . LYS A 1 390 ? 39.085  -32.292 -0.067  1.00 77.80  ? 402 LYS A CB  1 
ATOM   2932 C CG  . LYS A 1 390 ? 39.163  -33.458 -1.033  1.00 77.93  ? 402 LYS A CG  1 
ATOM   2933 C CD  . LYS A 1 390 ? 39.996  -34.601 -0.476  1.00 94.75  ? 402 LYS A CD  1 
ATOM   2934 C CE  . LYS A 1 390 ? 40.138  -35.760 -1.464  1.00 97.29  ? 402 LYS A CE  1 
ATOM   2935 N NZ  . LYS A 1 390 ? 41.080  -35.451 -2.590  1.00 86.45  ? 402 LYS A NZ  1 
ATOM   2936 N N   . GLY A 1 391 ? 36.431  -30.221 0.994   1.00 95.11  ? 403 GLY A N   1 
ATOM   2937 C CA  . GLY A 1 391 ? 36.145  -28.852 1.377   1.00 90.02  ? 403 GLY A CA  1 
ATOM   2938 C C   . GLY A 1 391 ? 36.890  -27.828 0.565   1.00 81.52  ? 403 GLY A C   1 
ATOM   2939 O O   . GLY A 1 391 ? 37.161  -26.743 1.063   1.00 89.78  ? 403 GLY A O   1 
ATOM   2940 N N   . GLN A 1 392 ? 37.215  -28.137 -0.681  1.00 73.02  ? 404 GLN A N   1 
ATOM   2941 C CA  . GLN A 1 392 ? 38.153  -27.342 -1.449  1.00 75.92  ? 404 GLN A CA  1 
ATOM   2942 C C   . GLN A 1 392 ? 37.598  -26.969 -2.821  1.00 79.35  ? 404 GLN A C   1 
ATOM   2943 O O   . GLN A 1 392 ? 38.338  -26.907 -3.807  1.00 79.54  ? 404 GLN A O   1 
ATOM   2944 C CB  . GLN A 1 392 ? 39.455  -28.103 -1.602  1.00 76.71  ? 404 GLN A CB  1 
ATOM   2945 C CG  . GLN A 1 392 ? 40.193  -28.305 -0.325  1.00 85.64  ? 404 GLN A CG  1 
ATOM   2946 C CD  . GLN A 1 392 ? 41.214  -29.419 -0.452  1.00 93.68  ? 404 GLN A CD  1 
ATOM   2947 O OE1 . GLN A 1 392 ? 41.473  -29.910 -1.554  1.00 89.75  ? 404 GLN A OE1 1 
ATOM   2948 N NE2 . GLN A 1 392 ? 41.778  -29.846 0.678   1.00 96.36  ? 404 GLN A NE2 1 
ATOM   2949 N N   . THR A 1 393 ? 36.310  -26.710 -2.905  1.00 79.44  ? 405 THR A N   1 
ATOM   2950 C CA  . THR A 1 393 ? 35.688  -26.404 -4.181  1.00 78.87  ? 405 THR A CA  1 
ATOM   2951 C C   . THR A 1 393 ? 36.266  -25.099 -4.707  1.00 79.70  ? 405 THR A C   1 
ATOM   2952 O O   . THR A 1 393 ? 36.105  -24.068 -4.043  1.00 86.95  ? 405 THR A O   1 
ATOM   2953 C CB  . THR A 1 393 ? 34.189  -26.260 -3.975  1.00 83.10  ? 405 THR A CB  1 
ATOM   2954 O OG1 . THR A 1 393 ? 33.915  -25.032 -3.287  1.00 91.10  ? 405 THR A OG1 1 
ATOM   2955 C CG2 . THR A 1 393 ? 33.706  -27.377 -3.081  1.00 74.76  ? 405 THR A CG2 1 
ATOM   2956 N N   . PRO A 1 394 ? 36.921  -25.081 -5.872  1.00 84.56  ? 406 PRO A N   1 
ATOM   2957 C CA  . PRO A 1 394 ? 37.580  -23.848 -6.341  1.00 91.32  ? 406 PRO A CA  1 
ATOM   2958 C C   . PRO A 1 394 ? 36.605  -22.689 -6.330  1.00 94.89  ? 406 PRO A C   1 
ATOM   2959 O O   . PRO A 1 394 ? 35.525  -22.775 -6.907  1.00 96.89  ? 406 PRO A O   1 
ATOM   2960 C CB  . PRO A 1 394 ? 38.014  -24.180 -7.776  1.00 92.10  ? 406 PRO A CB  1 
ATOM   2961 C CG  . PRO A 1 394 ? 37.336  -25.461 -8.113  1.00 96.69  ? 406 PRO A CG  1 
ATOM   2962 C CD  . PRO A 1 394 ? 37.104  -26.179 -6.824  1.00 90.57  ? 406 PRO A CD  1 
ATOM   2963 N N   . LYS A 1 395 ? 36.979  -21.606 -5.648  1.00 99.27  ? 407 LYS A N   1 
ATOM   2964 C CA  . LYS A 1 395 ? 36.026  -20.544 -5.341  1.00 96.15  ? 407 LYS A CA  1 
ATOM   2965 C C   . LYS A 1 395 ? 35.800  -19.717 -6.597  1.00 87.90  ? 407 LYS A C   1 
ATOM   2966 O O   . LYS A 1 395 ? 36.749  -19.162 -7.159  1.00 81.95  ? 407 LYS A O   1 
ATOM   2967 C CB  . LYS A 1 395 ? 36.530  -19.687 -4.184  1.00 96.22  ? 407 LYS A CB  1 
ATOM   2968 C CG  . LYS A 1 395 ? 35.450  -18.829 -3.546  1.00 105.94 ? 407 LYS A CG  1 
ATOM   2969 C CD  . LYS A 1 395 ? 34.464  -19.678 -2.709  1.00 111.23 ? 407 LYS A CD  1 
ATOM   2970 C CE  . LYS A 1 395 ? 34.175  -19.028 -1.348  1.00 116.96 ? 407 LYS A CE  1 
ATOM   2971 N NZ  . LYS A 1 395 ? 33.487  -17.691 -1.418  1.00 115.35 ? 407 LYS A NZ  1 
ATOM   2972 N N   . VAL A 1 396 ? 34.551  -19.669 -7.059  1.00 87.86  ? 408 VAL A N   1 
ATOM   2973 C CA  . VAL A 1 396 ? 34.236  -19.154 -8.385  1.00 90.03  ? 408 VAL A CA  1 
ATOM   2974 C C   . VAL A 1 396 ? 33.147  -18.114 -8.275  1.00 85.18  ? 408 VAL A C   1 
ATOM   2975 O O   . VAL A 1 396 ? 32.237  -18.217 -7.445  1.00 78.42  ? 408 VAL A O   1 
ATOM   2976 C CB  . VAL A 1 396 ? 33.754  -20.244 -9.360  1.00 89.83  ? 408 VAL A CB  1 
ATOM   2977 C CG1 . VAL A 1 396 ? 34.931  -21.016 -9.929  1.00 89.72  ? 408 VAL A CG1 1 
ATOM   2978 C CG2 . VAL A 1 396 ? 32.718  -21.146 -8.679  1.00 86.76  ? 408 VAL A CG2 1 
ATOM   2979 N N   . ALA A 1 397 ? 33.232  -17.124 -9.149  1.00 83.26  ? 409 ALA A N   1 
ATOM   2980 C CA  . ALA A 1 397 ? 32.121  -16.216 -9.314  1.00 82.51  ? 409 ALA A CA  1 
ATOM   2981 C C   . ALA A 1 397 ? 30.911  -17.022 -9.751  1.00 91.71  ? 409 ALA A C   1 
ATOM   2982 O O   . ALA A 1 397 ? 30.989  -17.771 -10.731 1.00 91.36  ? 409 ALA A O   1 
ATOM   2983 C CB  . ALA A 1 397 ? 32.470  -15.151 -10.339 1.00 79.31  ? 409 ALA A CB  1 
ATOM   2984 N N   . CYS A 1 398 ? 29.818  -16.907 -8.984  1.00 98.06  ? 410 CYS A N   1 
ATOM   2985 C CA  . CYS A 1 398 ? 28.580  -17.636 -9.253  1.00 90.16  ? 410 CYS A CA  1 
ATOM   2986 C C   . CYS A 1 398 ? 28.164  -17.413 -10.699 1.00 84.67  ? 410 CYS A C   1 
ATOM   2987 O O   . CYS A 1 398 ? 28.461  -16.372 -11.294 1.00 83.04  ? 410 CYS A O   1 
ATOM   2988 C CB  . CYS A 1 398 ? 27.473  -17.168 -8.289  1.00 91.35  ? 410 CYS A CB  1 
ATOM   2989 S SG  . CYS A 1 398 ? 25.992  -18.211 -8.047  1.00 81.38  ? 410 CYS A SG  1 
ATOM   2990 N N   . GLY A 1 399 ? 27.502  -18.411 -11.278 1.00 79.70  ? 411 GLY A N   1 
ATOM   2991 C CA  . GLY A 1 399 ? 27.198  -18.354 -12.689 1.00 83.90  ? 411 GLY A CA  1 
ATOM   2992 C C   . GLY A 1 399 ? 28.400  -18.390 -13.615 1.00 81.70  ? 411 GLY A C   1 
ATOM   2993 O O   . GLY A 1 399 ? 28.230  -18.303 -14.836 1.00 75.31  ? 411 GLY A O   1 
ATOM   2994 N N   . SER A 1 400 ? 29.610  -18.517 -13.094 1.00 79.19  ? 412 SER A N   1 
ATOM   2995 C CA  . SER A 1 400 ? 30.773  -18.577 -13.955 1.00 75.87  ? 412 SER A CA  1 
ATOM   2996 C C   . SER A 1 400 ? 31.587  -19.793 -13.594 1.00 76.04  ? 412 SER A C   1 
ATOM   2997 O O   . SER A 1 400 ? 31.218  -20.594 -12.733 1.00 77.06  ? 412 SER A O   1 
ATOM   2998 C CB  . SER A 1 400 ? 31.638  -17.321 -13.831 1.00 83.65  ? 412 SER A CB  1 
ATOM   2999 O OG  . SER A 1 400 ? 30.849  -16.168 -14.008 1.00 85.24  ? 412 SER A OG  1 
ATOM   3000 N N   . GLY A 1 401 ? 32.711  -19.924 -14.282 1.00 77.57  ? 413 GLY A N   1 
ATOM   3001 C CA  . GLY A 1 401 ? 33.739  -20.854 -13.894 1.00 81.40  ? 413 GLY A CA  1 
ATOM   3002 C C   . GLY A 1 401 ? 34.903  -20.137 -13.249 1.00 82.45  ? 413 GLY A C   1 
ATOM   3003 O O   . GLY A 1 401 ? 34.854  -18.936 -12.957 1.00 90.95  ? 413 GLY A O   1 
ATOM   3004 N N   . VAL A 1 402 ? 35.939  -20.921 -12.973 1.00 81.73  ? 414 VAL A N   1 
ATOM   3005 C CA  . VAL A 1 402 ? 37.249  -20.347 -12.676 1.00 86.41  ? 414 VAL A CA  1 
ATOM   3006 C C   . VAL A 1 402 ? 37.663  -19.472 -13.854 1.00 83.90  ? 414 VAL A C   1 
ATOM   3007 O O   . VAL A 1 402 ? 37.467  -19.866 -15.017 1.00 84.86  ? 414 VAL A O   1 
ATOM   3008 C CB  . VAL A 1 402 ? 38.290  -21.461 -12.413 1.00 88.36  ? 414 VAL A CB  1 
ATOM   3009 C CG1 . VAL A 1 402 ? 39.593  -20.857 -11.969 1.00 91.96  ? 414 VAL A CG1 1 
ATOM   3010 C CG2 . VAL A 1 402 ? 37.795  -22.462 -11.348 1.00 85.97  ? 414 VAL A CG2 1 
ATOM   3011 N N   . PRO A 1 403 ? 38.171  -18.270 -13.633 1.00 89.85  ? 415 PRO A N   1 
ATOM   3012 C CA  . PRO A 1 403 ? 38.698  -17.472 -14.740 1.00 90.73  ? 415 PRO A CA  1 
ATOM   3013 C C   . PRO A 1 403 ? 40.188  -17.728 -14.949 1.00 84.91  ? 415 PRO A C   1 
ATOM   3014 O O   . PRO A 1 403 ? 40.890  -18.232 -14.075 1.00 83.89  ? 415 PRO A O   1 
ATOM   3015 C CB  . PRO A 1 403 ? 38.426  -16.035 -14.280 1.00 90.87  ? 415 PRO A CB  1 
ATOM   3016 C CG  . PRO A 1 403 ? 38.506  -16.110 -12.773 1.00 87.02  ? 415 PRO A CG  1 
ATOM   3017 C CD  . PRO A 1 403 ? 38.023  -17.482 -12.391 1.00 87.74  ? 415 PRO A CD  1 
ATOM   3018 N N   . ALA A 1 404 ? 40.657  -17.354 -16.133 1.00 79.84  ? 416 ALA A N   1 
ATOM   3019 C CA  . ALA A 1 404 ? 41.977  -17.780 -16.587 1.00 91.09  ? 416 ALA A CA  1 
ATOM   3020 C C   . ALA A 1 404 ? 43.112  -17.434 -15.619 1.00 95.04  ? 416 ALA A C   1 
ATOM   3021 O O   . ALA A 1 404 ? 43.531  -16.279 -15.521 1.00 97.45  ? 416 ALA A O   1 
ATOM   3022 C CB  . ALA A 1 404 ? 42.244  -17.179 -17.964 1.00 84.87  ? 416 ALA A CB  1 
ATOM   3023 N N   . ILE A 1 405 ? 43.630  -18.437 -14.921 1.00 86.33  ? 417 ILE A N   1 
ATOM   3024 C CA  . ILE A 1 405 ? 44.669  -18.301 -13.905 1.00 82.24  ? 417 ILE A CA  1 
ATOM   3025 C C   . ILE A 1 405 ? 45.927  -18.979 -14.432 1.00 87.58  ? 417 ILE A C   1 
ATOM   3026 O O   . ILE A 1 405 ? 46.015  -20.213 -14.373 1.00 93.67  ? 417 ILE A O   1 
ATOM   3027 C CB  . ILE A 1 405 ? 44.258  -18.937 -12.576 1.00 86.48  ? 417 ILE A CB  1 
ATOM   3028 C CG1 . ILE A 1 405 ? 43.029  -18.270 -12.000 1.00 85.13  ? 417 ILE A CG1 1 
ATOM   3029 C CG2 . ILE A 1 405 ? 45.388  -18.892 -11.648 1.00 92.43  ? 417 ILE A CG2 1 
ATOM   3030 C CD1 . ILE A 1 405 ? 42.440  -19.020 -10.840 1.00 83.25  ? 417 ILE A CD1 1 
ATOM   3031 N N   . PRO A 1 406 ? 46.958  -18.235 -14.829 1.00 86.78  ? 418 PRO A N   1 
ATOM   3032 C CA  . PRO A 1 406 ? 48.114  -18.865 -15.478 1.00 88.72  ? 418 PRO A CA  1 
ATOM   3033 C C   . PRO A 1 406 ? 48.617  -20.041 -14.658 1.00 92.10  ? 418 PRO A C   1 
ATOM   3034 O O   . PRO A 1 406 ? 48.566  -20.031 -13.425 1.00 92.87  ? 418 PRO A O   1 
ATOM   3035 C CB  . PRO A 1 406 ? 49.148  -17.737 -15.536 1.00 86.80  ? 418 PRO A CB  1 
ATOM   3036 C CG  . PRO A 1 406 ? 48.353  -16.508 -15.582 1.00 86.99  ? 418 PRO A CG  1 
ATOM   3037 C CD  . PRO A 1 406 ? 47.121  -16.784 -14.732 1.00 88.33  ? 418 PRO A CD  1 
ATOM   3038 N N   . GLY A 1 407 ? 49.031  -21.092 -15.352 1.00 92.01  ? 419 GLY A N   1 
ATOM   3039 C CA  . GLY A 1 407 ? 49.618  -22.232 -14.671 1.00 102.12 ? 419 GLY A CA  1 
ATOM   3040 C C   . GLY A 1 407 ? 48.665  -23.142 -13.917 1.00 98.89  ? 419 GLY A C   1 
ATOM   3041 O O   . GLY A 1 407 ? 48.973  -24.310 -13.646 1.00 89.60  ? 419 GLY A O   1 
ATOM   3042 N N   . ILE A 1 408 ? 47.507  -22.611 -13.553 1.00 95.28  ? 420 ILE A N   1 
ATOM   3043 C CA  . ILE A 1 408 ? 46.462  -23.407 -12.941 1.00 104.74 ? 420 ILE A CA  1 
ATOM   3044 C C   . ILE A 1 408 ? 45.443  -23.880 -13.968 1.00 105.66 ? 420 ILE A C   1 
ATOM   3045 O O   . ILE A 1 408 ? 44.915  -24.987 -13.850 1.00 103.07 ? 420 ILE A O   1 
ATOM   3046 C CB  . ILE A 1 408 ? 45.803  -22.609 -11.795 1.00 107.28 ? 420 ILE A CB  1 
ATOM   3047 C CG1 . ILE A 1 408 ? 46.871  -22.285 -10.747 1.00 109.07 ? 420 ILE A CG1 1 
ATOM   3048 C CG2 . ILE A 1 408 ? 44.582  -23.343 -11.200 1.00 107.57 ? 420 ILE A CG2 1 
ATOM   3049 C CD1 . ILE A 1 408 ? 46.460  -21.312 -9.664  1.00 110.48 ? 420 ILE A CD1 1 
ATOM   3050 N N   . ASN A 1 409 ? 45.183  -23.076 -14.997 1.00 96.07  ? 421 ASN A N   1 
ATOM   3051 C CA  . ASN A 1 409 ? 44.194  -23.463 -15.985 1.00 89.41  ? 421 ASN A CA  1 
ATOM   3052 C C   . ASN A 1 409 ? 44.362  -22.670 -17.273 1.00 91.30  ? 421 ASN A C   1 
ATOM   3053 O O   . ASN A 1 409 ? 43.471  -22.657 -18.129 1.00 94.99  ? 421 ASN A O   1 
ATOM   3054 C CB  . ASN A 1 409 ? 42.777  -23.311 -15.392 1.00 93.83  ? 421 ASN A CB  1 
ATOM   3055 C CG  . ASN A 1 409 ? 42.244  -21.856 -15.382 1.00 96.91  ? 421 ASN A CG  1 
ATOM   3056 O OD1 . ASN A 1 409 ? 42.847  -20.920 -15.911 1.00 98.62  ? 421 ASN A OD1 1 
ATOM   3057 N ND2 . ASN A 1 409 ? 41.070  -21.685 -14.768 1.00 89.10  ? 421 ASN A ND2 1 
ATOM   3058 N N   . SER A 1 410 ? 45.474  -21.985 -17.406 1.00 89.42  ? 422 SER A N   1 
ATOM   3059 C CA  . SER A 1 410 ? 45.738  -21.285 -18.649 1.00 92.87  ? 422 SER A CA  1 
ATOM   3060 C C   . SER A 1 410 ? 47.243  -21.384 -18.819 1.00 90.83  ? 422 SER A C   1 
ATOM   3061 O O   . SER A 1 410 ? 47.919  -21.893 -17.918 1.00 90.27  ? 422 SER A O   1 
ATOM   3062 C CB  . SER A 1 410 ? 45.237  -19.829 -18.622 1.00 90.06  ? 422 SER A CB  1 
ATOM   3063 O OG  . SER A 1 410 ? 46.088  -18.988 -17.866 1.00 94.39  ? 422 SER A OG  1 
ATOM   3064 N N   . PRO A 1 411 ? 47.797  -20.976 -19.955 1.00 90.08  ? 423 PRO A N   1 
ATOM   3065 C CA  . PRO A 1 411 ? 49.257  -21.005 -20.109 1.00 94.11  ? 423 PRO A CA  1 
ATOM   3066 C C   . PRO A 1 411 ? 50.017  -20.366 -18.948 1.00 101.29 ? 423 PRO A C   1 
ATOM   3067 O O   . PRO A 1 411 ? 49.466  -19.563 -18.183 1.00 98.71  ? 423 PRO A O   1 
ATOM   3068 C CB  . PRO A 1 411 ? 49.467  -20.242 -21.420 1.00 86.19  ? 423 PRO A CB  1 
ATOM   3069 C CG  . PRO A 1 411 ? 48.216  -20.533 -22.197 1.00 87.03  ? 423 PRO A CG  1 
ATOM   3070 C CD  . PRO A 1 411 ? 47.122  -20.528 -21.190 1.00 88.17  ? 423 PRO A CD  1 
ATOM   3071 N N   . SER A 1 412 ? 51.289  -20.733 -18.810 1.00 101.13 ? 424 SER A N   1 
ATOM   3072 C CA  . SER A 1 412 ? 52.111  -20.253 -17.716 1.00 96.58  ? 424 SER A CA  1 
ATOM   3073 C C   . SER A 1 412 ? 52.664  -18.873 -18.027 1.00 96.56  ? 424 SER A C   1 
ATOM   3074 O O   . SER A 1 412 ? 52.961  -18.543 -19.184 1.00 91.85  ? 424 SER A O   1 
ATOM   3075 C CB  . SER A 1 412 ? 53.271  -21.208 -17.456 1.00 103.21 ? 424 SER A CB  1 
ATOM   3076 O OG  . SER A 1 412 ? 54.328  -20.973 -18.375 1.00 106.72 ? 424 SER A OG  1 
ATOM   3077 N N   . THR A 1 413 ? 52.846  -18.092 -16.956 1.00 94.72  ? 425 THR A N   1 
ATOM   3078 C CA  . THR A 1 413 ? 53.300  -16.711 -17.064 1.00 93.64  ? 425 THR A CA  1 
ATOM   3079 C C   . THR A 1 413 ? 54.564  -16.607 -17.901 1.00 97.75  ? 425 THR A C   1 
ATOM   3080 O O   . THR A 1 413 ? 54.825  -15.562 -18.523 1.00 87.95  ? 425 THR A O   1 
ATOM   3081 C CB  . THR A 1 413 ? 53.552  -16.176 -15.670 1.00 89.77  ? 425 THR A CB  1 
ATOM   3082 O OG1 . THR A 1 413 ? 52.437  -16.522 -14.842 1.00 84.18  ? 425 THR A OG1 1 
ATOM   3083 C CG2 . THR A 1 413 ? 53.731  -14.668 -15.717 1.00 93.39  ? 425 THR A CG2 1 
ATOM   3084 N N   . GLN A 1 414 ? 55.348  -17.697 -17.934 1.00 103.41 ? 426 GLN A N   1 
ATOM   3085 C CA  . GLN A 1 414 ? 56.590  -17.733 -18.685 1.00 103.61 ? 426 GLN A CA  1 
ATOM   3086 C C   . GLN A 1 414 ? 56.358  -18.185 -20.110 1.00 101.65 ? 426 GLN A C   1 
ATOM   3087 O O   . GLN A 1 414 ? 56.947  -17.634 -21.042 1.00 99.95  ? 426 GLN A O   1 
ATOM   3088 C CB  . GLN A 1 414 ? 57.576  -18.666 -18.010 1.00 101.45 ? 426 GLN A CB  1 
ATOM   3089 C CG  . GLN A 1 414 ? 57.835  -18.280 -16.580 1.00 119.25 ? 426 GLN A CG  1 
ATOM   3090 C CD  . GLN A 1 414 ? 59.315  -18.101 -16.272 1.00 133.90 ? 426 GLN A CD  1 
ATOM   3091 O OE1 . GLN A 1 414 ? 59.835  -16.977 -16.293 1.00 135.36 ? 426 GLN A OE1 1 
ATOM   3092 N NE2 . GLN A 1 414 ? 60.015  -19.209 -16.061 1.00 139.39 ? 426 GLN A NE2 1 
ATOM   3093 N N   . ASN A 1 415 ? 55.517  -19.199 -20.292 1.00 96.98  ? 427 ASN A N   1 
ATOM   3094 C CA  . ASN A 1 415 ? 55.192  -19.628 -21.641 1.00 93.42  ? 427 ASN A CA  1 
ATOM   3095 C C   . ASN A 1 415 ? 54.530  -18.520 -22.421 1.00 93.02  ? 427 ASN A C   1 
ATOM   3096 O O   . ASN A 1 415 ? 54.646  -18.483 -23.650 1.00 97.02  ? 427 ASN A O   1 
ATOM   3097 C CB  . ASN A 1 415 ? 54.300  -20.852 -21.609 1.00 96.75  ? 427 ASN A CB  1 
ATOM   3098 C CG  . ASN A 1 415 ? 54.983  -22.024 -20.950 1.00 106.98 ? 427 ASN A CG  1 
ATOM   3099 O OD1 . ASN A 1 415 ? 54.338  -22.877 -20.333 1.00 108.20 ? 427 ASN A OD1 1 
ATOM   3100 N ND2 . ASN A 1 415 ? 56.304  -22.085 -21.089 1.00 104.32 ? 427 ASN A ND2 1 
ATOM   3101 N N   . VAL A 1 416 ? 53.859  -17.601 -21.730 1.00 91.09  ? 428 VAL A N   1 
ATOM   3102 C CA  . VAL A 1 416 ? 53.109  -16.564 -22.420 1.00 87.80  ? 428 VAL A CA  1 
ATOM   3103 C C   . VAL A 1 416 ? 54.021  -15.406 -22.786 1.00 91.77  ? 428 VAL A C   1 
ATOM   3104 O O   . VAL A 1 416 ? 54.120  -14.995 -23.948 1.00 89.51  ? 428 VAL A O   1 
ATOM   3105 C CB  . VAL A 1 416 ? 51.955  -16.079 -21.536 1.00 84.30  ? 428 VAL A CB  1 
ATOM   3106 C CG1 . VAL A 1 416 ? 51.184  -14.982 -22.263 1.00 84.27  ? 428 VAL A CG1 1 
ATOM   3107 C CG2 . VAL A 1 416 ? 51.080  -17.225 -21.120 1.00 88.92  ? 428 VAL A CG2 1 
ATOM   3108 N N   . LEU A 1 417 ? 54.689  -14.845 -21.788 1.00 92.96  ? 429 LEU A N   1 
ATOM   3109 C CA  . LEU A 1 417 ? 55.497  -13.653 -21.957 1.00 94.65  ? 429 LEU A CA  1 
ATOM   3110 C C   . LEU A 1 417 ? 56.958  -13.963 -22.194 1.00 102.47 ? 429 LEU A C   1 
ATOM   3111 O O   . LEU A 1 417 ? 57.690  -13.092 -22.672 1.00 102.38 ? 429 LEU A O   1 
ATOM   3112 C CB  . LEU A 1 417 ? 55.338  -12.754 -20.723 1.00 97.00  ? 429 LEU A CB  1 
ATOM   3113 C CG  . LEU A 1 417 ? 53.942  -12.624 -20.117 1.00 96.43  ? 429 LEU A CG  1 
ATOM   3114 C CD1 . LEU A 1 417 ? 54.000  -11.887 -18.823 1.00 95.11  ? 429 LEU A CD1 1 
ATOM   3115 C CD2 . LEU A 1 417 ? 53.106  -11.796 -21.092 1.00 92.44  ? 429 LEU A CD2 1 
ATOM   3116 N N   . GLY A 1 418 ? 57.391  -15.180 -21.912 1.00 103.35 ? 430 GLY A N   1 
ATOM   3117 C CA  . GLY A 1 418 ? 58.809  -15.425 -21.793 1.00 111.90 ? 430 GLY A CA  1 
ATOM   3118 C C   . GLY A 1 418 ? 59.284  -15.220 -20.367 1.00 109.21 ? 430 GLY A C   1 
ATOM   3119 O O   . GLY A 1 418 ? 58.560  -14.731 -19.503 1.00 105.28 ? 430 GLY A O   1 
ATOM   3120 N N   . SER A 1 419 ? 60.536  -15.619 -20.123 1.00 112.97 ? 431 SER A N   1 
ATOM   3121 C CA  . SER A 1 419 ? 61.034  -15.663 -18.754 1.00 111.27 ? 431 SER A CA  1 
ATOM   3122 C C   . SER A 1 419 ? 61.193  -14.267 -18.188 1.00 108.60 ? 431 SER A C   1 
ATOM   3123 O O   . SER A 1 419 ? 60.694  -13.966 -17.099 1.00 112.31 ? 431 SER A O   1 
ATOM   3124 C CB  . SER A 1 419 ? 62.353  -16.429 -18.681 1.00 114.65 ? 431 SER A CB  1 
ATOM   3125 O OG  . SER A 1 419 ? 62.173  -17.786 -19.045 1.00 120.46 ? 431 SER A OG  1 
ATOM   3126 N N   . ASP A 1 420 ? 61.875  -13.395 -18.916 1.00 101.60 ? 432 ASP A N   1 
ATOM   3127 C CA  . ASP A 1 420 ? 62.099  -12.054 -18.403 1.00 104.66 ? 432 ASP A CA  1 
ATOM   3128 C C   . ASP A 1 420 ? 60.784  -11.381 -18.074 1.00 102.23 ? 432 ASP A C   1 
ATOM   3129 O O   . ASP A 1 420 ? 60.474  -11.123 -16.907 1.00 101.18 ? 432 ASP A O   1 
ATOM   3130 C CB  . ASP A 1 420 ? 62.875  -11.246 -19.423 1.00 112.81 ? 432 ASP A CB  1 
ATOM   3131 C CG  . ASP A 1 420 ? 64.257  -11.766 -19.595 1.00 118.80 ? 432 ASP A CG  1 
ATOM   3132 O OD1 . ASP A 1 420 ? 64.570  -12.786 -18.942 1.00 122.20 ? 432 ASP A OD1 1 
ATOM   3133 O OD2 . ASP A 1 420 ? 65.023  -11.171 -20.371 1.00 113.87 ? 432 ASP A OD2 1 
ATOM   3134 N N   . LEU A 1 421 ? 59.984  -11.120 -19.101 1.00 98.41  ? 433 LEU A N   1 
ATOM   3135 C CA  . LEU A 1 421 ? 58.709  -10.456 -18.900 1.00 93.30  ? 433 LEU A CA  1 
ATOM   3136 C C   . LEU A 1 421 ? 57.904  -11.098 -17.786 1.00 98.41  ? 433 LEU A C   1 
ATOM   3137 O O   . LEU A 1 421 ? 57.210  -10.400 -17.045 1.00 101.66 ? 433 LEU A O   1 
ATOM   3138 C CB  . LEU A 1 421 ? 57.928  -10.480 -20.194 1.00 93.12  ? 433 LEU A CB  1 
ATOM   3139 C CG  . LEU A 1 421 ? 58.491  -9.506  -21.218 1.00 94.19  ? 433 LEU A CG  1 
ATOM   3140 C CD1 . LEU A 1 421 ? 57.378  -9.161  -22.133 1.00 96.24  ? 433 LEU A CD1 1 
ATOM   3141 C CD2 . LEU A 1 421 ? 59.044  -8.259  -20.586 1.00 91.57  ? 433 LEU A CD2 1 
ATOM   3142 N N   . ALA A 1 422 ? 58.006  -12.415 -17.622 1.00 99.96  ? 434 ALA A N   1 
ATOM   3143 C CA  . ALA A 1 422 ? 57.325  -13.056 -16.508 1.00 101.39 ? 434 ALA A CA  1 
ATOM   3144 C C   . ALA A 1 422 ? 57.996  -12.721 -15.180 1.00 101.50 ? 434 ALA A C   1 
ATOM   3145 O O   . ALA A 1 422 ? 57.313  -12.531 -14.168 1.00 101.87 ? 434 ALA A O   1 
ATOM   3146 C CB  . ALA A 1 422 ? 57.272  -14.564 -16.730 1.00 107.50 ? 434 ALA A CB  1 
ATOM   3147 N N   . ASN A 1 423 ? 59.327  -12.636 -15.154 1.00 99.31  ? 435 ASN A N   1 
ATOM   3148 C CA  . ASN A 1 423 ? 60.003  -12.217 -13.928 1.00 102.34 ? 435 ASN A CA  1 
ATOM   3149 C C   . ASN A 1 423 ? 59.659  -10.779 -13.582 1.00 105.29 ? 435 ASN A C   1 
ATOM   3150 O O   . ASN A 1 423 ? 59.403  -10.451 -12.416 1.00 106.99 ? 435 ASN A O   1 
ATOM   3151 C CB  . ASN A 1 423 ? 61.514  -12.360 -14.069 1.00 107.93 ? 435 ASN A CB  1 
ATOM   3152 C CG  . ASN A 1 423 ? 61.950  -13.779 -14.310 1.00 116.88 ? 435 ASN A CG  1 
ATOM   3153 O OD1 . ASN A 1 423 ? 61.413  -14.727 -13.714 1.00 124.65 ? 435 ASN A OD1 1 
ATOM   3154 N ND2 . ASN A 1 423 ? 62.917  -13.945 -15.209 1.00 112.05 ? 435 ASN A ND2 1 
ATOM   3155 N N   . GLN A 1 424 ? 59.675  -9.895  -14.584 1.00 100.18 ? 436 GLN A N   1 
ATOM   3156 C CA  . GLN A 1 424 ? 59.274  -8.518  -14.337 1.00 94.32  ? 436 GLN A CA  1 
ATOM   3157 C C   . GLN A 1 424 ? 57.878  -8.456  -13.728 1.00 95.55  ? 436 GLN A C   1 
ATOM   3158 O O   . GLN A 1 424 ? 57.677  -7.838  -12.679 1.00 94.25  ? 436 GLN A O   1 
ATOM   3159 C CB  . GLN A 1 424 ? 59.393  -7.691  -15.623 1.00 92.65  ? 436 GLN A CB  1 
ATOM   3160 C CG  . GLN A 1 424 ? 60.854  -7.511  -16.089 1.00 101.92 ? 436 GLN A CG  1 
ATOM   3161 C CD  . GLN A 1 424 ? 61.050  -7.276  -17.588 1.00 109.74 ? 436 GLN A CD  1 
ATOM   3162 O OE1 . GLN A 1 424 ? 60.316  -6.500  -18.208 1.00 111.63 ? 436 GLN A OE1 1 
ATOM   3163 N NE2 . GLN A 1 424 ? 62.100  -7.880  -18.154 1.00 109.06 ? 436 GLN A NE2 1 
ATOM   3164 N N   . LEU A 1 425 ? 56.915  -9.148  -14.337 1.00 96.09  ? 437 LEU A N   1 
ATOM   3165 C CA  . LEU A 1 425 ? 55.585  -9.266  -13.747 1.00 93.56  ? 437 LEU A CA  1 
ATOM   3166 C C   . LEU A 1 425 ? 55.619  -9.824  -12.326 1.00 99.52  ? 437 LEU A C   1 
ATOM   3167 O O   . LEU A 1 425 ? 54.838  -9.395  -11.471 1.00 101.84 ? 437 LEU A O   1 
ATOM   3168 C CB  . LEU A 1 425 ? 54.714  -10.130 -14.647 1.00 99.05  ? 437 LEU A CB  1 
ATOM   3169 C CG  . LEU A 1 425 ? 53.206  -9.936  -14.596 1.00 102.12 ? 437 LEU A CG  1 
ATOM   3170 C CD1 . LEU A 1 425 ? 52.625  -10.316 -15.940 1.00 100.81 ? 437 LEU A CD1 1 
ATOM   3171 C CD2 . LEU A 1 425 ? 52.588  -10.824 -13.489 1.00 94.43  ? 437 LEU A CD2 1 
ATOM   3172 N N   . ASN A 1 426 ? 56.489  -10.794 -12.049 1.00 100.78 ? 438 ASN A N   1 
ATOM   3173 C CA  . ASN A 1 426 ? 56.534  -11.346 -10.697 1.00 105.02 ? 438 ASN A CA  1 
ATOM   3174 C C   . ASN A 1 426 ? 57.196  -10.402 -9.701  1.00 104.13 ? 438 ASN A C   1 
ATOM   3175 O O   . ASN A 1 426 ? 57.127  -10.645 -8.486  1.00 103.20 ? 438 ASN A O   1 
ATOM   3176 C CB  . ASN A 1 426 ? 57.247  -12.703 -10.677 1.00 112.87 ? 438 ASN A CB  1 
ATOM   3177 C CG  . ASN A 1 426 ? 56.546  -13.744 -11.531 1.00 107.15 ? 438 ASN A CG  1 
ATOM   3178 O OD1 . ASN A 1 426 ? 55.320  -13.827 -11.530 1.00 105.00 ? 438 ASN A OD1 1 
ATOM   3179 N ND2 . ASN A 1 426 ? 57.320  -14.544 -12.262 1.00 108.82 ? 438 ASN A ND2 1 
ATOM   3180 N N   . SER A 1 427 ? 57.844  -9.340  -10.181 1.00 99.94  ? 439 SER A N   1 
ATOM   3181 C CA  . SER A 1 427 ? 58.389  -8.363  -9.252  1.00 101.38 ? 439 SER A CA  1 
ATOM   3182 C C   . SER A 1 427 ? 57.306  -7.404  -8.780  1.00 102.16 ? 439 SER A C   1 
ATOM   3183 O O   . SER A 1 427 ? 57.294  -7.009  -7.610  1.00 101.72 ? 439 SER A O   1 
ATOM   3184 C CB  . SER A 1 427 ? 59.523  -7.579  -9.901  1.00 104.66 ? 439 SER A CB  1 
ATOM   3185 O OG  . SER A 1 427 ? 59.028  -6.445  -10.606 1.00 103.69 ? 439 SER A OG  1 
ATOM   3186 N N   . LEU A 1 428 ? 56.375  -7.037  -9.673  1.00 100.50 ? 440 LEU A N   1 
ATOM   3187 C CA  . LEU A 1 428 ? 55.402  -5.973  -9.427  1.00 87.84  ? 440 LEU A CA  1 
ATOM   3188 C C   . LEU A 1 428 ? 54.600  -6.244  -8.170  1.00 84.47  ? 440 LEU A C   1 
ATOM   3189 O O   . LEU A 1 428 ? 53.881  -5.370  -7.686  1.00 87.04  ? 440 LEU A O   1 
ATOM   3190 C CB  . LEU A 1 428 ? 54.446  -5.806  -10.612 1.00 79.59  ? 440 LEU A CB  1 
ATOM   3191 C CG  . LEU A 1 428 ? 54.941  -5.137  -11.889 1.00 82.70  ? 440 LEU A CG  1 
ATOM   3192 C CD1 . LEU A 1 428 ? 53.795  -4.558  -12.688 1.00 76.96  ? 440 LEU A CD1 1 
ATOM   3193 C CD2 . LEU A 1 428 ? 55.980  -4.073  -11.613 1.00 89.69  ? 440 LEU A CD2 1 
ATOM   3194 N N   . LYS A 1 429 ? 54.697  -7.456  -7.654  1.00 82.12  ? 441 LYS A N   1 
ATOM   3195 C CA  . LYS A 1 429 ? 54.007  -7.790  -6.426  1.00 87.13  ? 441 LYS A CA  1 
ATOM   3196 C C   . LYS A 1 429 ? 54.399  -6.790  -5.348  1.00 84.62  ? 441 LYS A C   1 
ATOM   3197 O O   . LYS A 1 429 ? 55.513  -6.269  -5.338  1.00 92.30  ? 441 LYS A O   1 
ATOM   3198 C CB  . LYS A 1 429 ? 54.350  -9.231  -6.026  1.00 94.31  ? 441 LYS A CB  1 
ATOM   3199 C CG  . LYS A 1 429 ? 53.593  -9.783  -4.833  1.00 88.75  ? 441 LYS A CG  1 
ATOM   3200 C CD  . LYS A 1 429 ? 53.940  -11.245 -4.606  1.00 90.46  ? 441 LYS A CD  1 
ATOM   3201 C CE  . LYS A 1 429 ? 53.009  -11.853 -3.559  1.00 105.74 ? 441 LYS A CE  1 
ATOM   3202 N NZ  . LYS A 1 429 ? 53.382  -13.221 -3.083  1.00 103.37 ? 441 LYS A NZ  1 
ATOM   3203 N N   . GLY A 1 430 ? 53.447  -6.464  -4.477  1.00 85.50  ? 442 GLY A N   1 
ATOM   3204 C CA  . GLY A 1 430 ? 53.670  -5.547  -3.371  1.00 85.01  ? 442 GLY A CA  1 
ATOM   3205 C C   . GLY A 1 430 ? 53.948  -4.107  -3.744  1.00 81.93  ? 442 GLY A C   1 
ATOM   3206 O O   . GLY A 1 430 ? 53.912  -3.241  -2.863  1.00 74.43  ? 442 GLY A O   1 
ATOM   3207 N N   . GLN A 1 431 ? 54.215  -3.817  -5.009  1.00 83.68  ? 443 GLN A N   1 
ATOM   3208 C CA  . GLN A 1 431 ? 54.575  -2.475  -5.421  1.00 80.56  ? 443 GLN A CA  1 
ATOM   3209 C C   . GLN A 1 431 ? 53.336  -1.645  -5.709  1.00 81.43  ? 443 GLN A C   1 
ATOM   3210 O O   . GLN A 1 431 ? 52.294  -2.151  -6.133  1.00 83.68  ? 443 GLN A O   1 
ATOM   3211 C CB  . GLN A 1 431 ? 55.486  -2.529  -6.641  1.00 81.28  ? 443 GLN A CB  1 
ATOM   3212 C CG  . GLN A 1 431 ? 56.864  -3.057  -6.277  1.00 86.04  ? 443 GLN A CG  1 
ATOM   3213 C CD  . GLN A 1 431 ? 57.848  -2.911  -7.406  1.00 103.95 ? 443 GLN A CD  1 
ATOM   3214 O OE1 . GLN A 1 431 ? 57.825  -1.919  -8.135  1.00 111.04 ? 443 GLN A OE1 1 
ATOM   3215 N NE2 . GLN A 1 431 ? 58.751  -3.880  -7.538  1.00 110.43 ? 443 GLN A NE2 1 
ATOM   3216 N N   . GLN A 1 432 ? 53.458  -0.356  -5.458  1.00 83.18  ? 444 GLN A N   1 
ATOM   3217 C CA  . GLN A 1 432 ? 52.301  0.517   -5.523  1.00 88.24  ? 444 GLN A CA  1 
ATOM   3218 C C   . GLN A 1 432 ? 51.830  0.647   -6.966  1.00 80.93  ? 444 GLN A C   1 
ATOM   3219 O O   . GLN A 1 432 ? 52.586  1.076   -7.840  1.00 74.52  ? 444 GLN A O   1 
ATOM   3220 C CB  . GLN A 1 432 ? 52.653  1.875   -4.914  1.00 97.67  ? 444 GLN A CB  1 
ATOM   3221 C CG  . GLN A 1 432 ? 52.566  1.890   -3.377  1.00 98.55  ? 444 GLN A CG  1 
ATOM   3222 C CD  . GLN A 1 432 ? 51.132  2.010   -2.878  1.00 99.44  ? 444 GLN A CD  1 
ATOM   3223 O OE1 . GLN A 1 432 ? 50.363  2.795   -3.430  1.00 94.28  ? 444 GLN A OE1 1 
ATOM   3224 N NE2 . GLN A 1 432 ? 50.767  1.244   -1.838  1.00 93.20  ? 444 GLN A NE2 1 
ATOM   3225 N N   . SER A 1 433 ? 50.587  0.248   -7.214  1.00 80.40  ? 445 SER A N   1 
ATOM   3226 C CA  . SER A 1 433 ? 49.954  0.398   -8.515  1.00 79.19  ? 445 SER A CA  1 
ATOM   3227 C C   . SER A 1 433 ? 49.847  1.858   -8.908  1.00 75.17  ? 445 SER A C   1 
ATOM   3228 O O   . SER A 1 433 ? 50.203  2.741   -8.132  1.00 84.79  ? 445 SER A O   1 
ATOM   3229 C CB  . SER A 1 433 ? 48.579  -0.265  -8.491  1.00 77.89  ? 445 SER A CB  1 
ATOM   3230 O OG  . SER A 1 433 ? 47.666  0.531   -7.771  1.00 77.98  ? 445 SER A OG  1 
ATOM   3231 N N   . ALA A 1 434 ? 49.364  2.143   -10.102 1.00 72.00  ? 446 ALA A N   1 
ATOM   3232 C CA  . ALA A 1 434 ? 49.072  3.534   -10.423 1.00 78.65  ? 446 ALA A CA  1 
ATOM   3233 C C   . ALA A 1 434 ? 47.817  4.047   -9.725  1.00 78.11  ? 446 ALA A C   1 
ATOM   3234 O O   . ALA A 1 434 ? 47.298  5.101   -10.100 1.00 78.10  ? 446 ALA A O   1 
ATOM   3235 C CB  . ALA A 1 434 ? 48.945  3.715   -11.934 1.00 78.56  ? 446 ALA A CB  1 
ATOM   3236 N N   . PHE A 1 435 ? 47.333  3.326   -8.716  1.00 75.41  ? 447 PHE A N   1 
ATOM   3237 C CA  . PHE A 1 435 ? 46.097  3.671   -8.030  1.00 78.45  ? 447 PHE A CA  1 
ATOM   3238 C C   . PHE A 1 435 ? 46.257  3.698   -6.521  1.00 77.17  ? 447 PHE A C   1 
ATOM   3239 O O   . PHE A 1 435 ? 45.265  3.878   -5.809  1.00 70.76  ? 447 PHE A O   1 
ATOM   3240 C CB  . PHE A 1 435 ? 44.952  2.698   -8.413  1.00 80.19  ? 447 PHE A CB  1 
ATOM   3241 C CG  . PHE A 1 435 ? 44.511  2.802   -9.855  1.00 78.21  ? 447 PHE A CG  1 
ATOM   3242 C CD1 . PHE A 1 435 ? 45.259  2.240   -10.873 1.00 80.59  ? 447 PHE A CD1 1 
ATOM   3243 C CD2 . PHE A 1 435 ? 43.324  3.428   -10.189 1.00 78.87  ? 447 PHE A CD2 1 
ATOM   3244 C CE1 . PHE A 1 435 ? 44.860  2.367   -12.202 1.00 79.73  ? 447 PHE A CE1 1 
ATOM   3245 C CE2 . PHE A 1 435 ? 42.919  3.537   -11.516 1.00 78.07  ? 447 PHE A CE2 1 
ATOM   3246 C CZ  . PHE A 1 435 ? 43.686  3.009   -12.515 1.00 75.23  ? 447 PHE A CZ  1 
ATOM   3247 N N   . GLY A 1 436 ? 47.465  3.534   -6.015  1.00 79.29  ? 448 GLY A N   1 
ATOM   3248 C CA  . GLY A 1 436 ? 47.692  3.693   -4.600  1.00 87.34  ? 448 GLY A CA  1 
ATOM   3249 C C   . GLY A 1 436 ? 47.621  2.412   -3.835  1.00 87.95  ? 448 GLY A C   1 
ATOM   3250 O O   . GLY A 1 436 ? 47.793  2.426   -2.606  1.00 90.29  ? 448 GLY A O   1 
ATOM   3251 N N   . LYS A 1 437 ? 47.400  1.303   -4.523  1.00 87.33  ? 449 LYS A N   1 
ATOM   3252 C CA  . LYS A 1 437 ? 47.301  0.046   -3.831  1.00 85.38  ? 449 LYS A CA  1 
ATOM   3253 C C   . LYS A 1 437 ? 48.377  -0.903  -4.333  1.00 82.14  ? 449 LYS A C   1 
ATOM   3254 O O   . LYS A 1 437 ? 48.830  -0.799  -5.479  1.00 78.33  ? 449 LYS A O   1 
ATOM   3255 C CB  . LYS A 1 437 ? 45.912  -0.557  -4.039  1.00 79.07  ? 449 LYS A CB  1 
ATOM   3256 C CG  . LYS A 1 437 ? 44.822  0.472   -3.848  1.00 75.12  ? 449 LYS A CG  1 
ATOM   3257 C CD  . LYS A 1 437 ? 43.420  -0.049  -4.119  1.00 78.64  ? 449 LYS A CD  1 
ATOM   3258 C CE  . LYS A 1 437 ? 42.882  -0.884  -2.986  1.00 81.54  ? 449 LYS A CE  1 
ATOM   3259 N NZ  . LYS A 1 437 ? 41.523  -1.372  -3.348  1.00 87.27  ? 449 LYS A NZ  1 
ATOM   3260 N N   . PRO A 1 438 ? 48.834  -1.809  -3.484  1.00 83.07  ? 450 PRO A N   1 
ATOM   3261 C CA  . PRO A 1 438 ? 49.726  -2.855  -3.967  1.00 85.11  ? 450 PRO A CA  1 
ATOM   3262 C C   . PRO A 1 438 ? 49.170  -3.515  -5.221  1.00 90.37  ? 450 PRO A C   1 
ATOM   3263 O O   . PRO A 1 438 ? 47.953  -3.647  -5.408  1.00 88.68  ? 450 PRO A O   1 
ATOM   3264 C CB  . PRO A 1 438 ? 49.810  -3.833  -2.785  1.00 82.50  ? 450 PRO A CB  1 
ATOM   3265 C CG  . PRO A 1 438 ? 48.710  -3.454  -1.847  1.00 87.44  ? 450 PRO A CG  1 
ATOM   3266 C CD  . PRO A 1 438 ? 48.480  -1.989  -2.066  1.00 87.98  ? 450 PRO A CD  1 
ATOM   3267 N N   . PHE A 1 439 ? 50.087  -3.858  -6.116  1.00 88.36  ? 451 PHE A N   1 
ATOM   3268 C CA  . PHE A 1 439 ? 49.821  -4.862  -7.124  1.00 83.92  ? 451 PHE A CA  1 
ATOM   3269 C C   . PHE A 1 439 ? 49.727  -6.249  -6.485  1.00 90.76  ? 451 PHE A C   1 
ATOM   3270 O O   . PHE A 1 439 ? 50.187  -6.477  -5.359  1.00 84.19  ? 451 PHE A O   1 
ATOM   3271 C CB  . PHE A 1 439 ? 50.914  -4.845  -8.172  1.00 73.63  ? 451 PHE A CB  1 
ATOM   3272 C CG  . PHE A 1 439 ? 50.725  -3.820  -9.225  1.00 71.69  ? 451 PHE A CG  1 
ATOM   3273 C CD1 . PHE A 1 439 ? 49.494  -3.648  -9.812  1.00 76.22  ? 451 PHE A CD1 1 
ATOM   3274 C CD2 . PHE A 1 439 ? 51.784  -3.093  -9.696  1.00 68.43  ? 451 PHE A CD2 1 
ATOM   3275 C CE1 . PHE A 1 439 ? 49.317  -2.731  -10.823 1.00 72.73  ? 451 PHE A CE1 1 
ATOM   3276 C CE2 . PHE A 1 439 ? 51.607  -2.181  -10.706 1.00 72.88  ? 451 PHE A CE2 1 
ATOM   3277 C CZ  . PHE A 1 439 ? 50.369  -2.000  -11.270 1.00 70.39  ? 451 PHE A CZ  1 
ATOM   3278 N N   . GLY A 1 440 ? 49.117  -7.183  -7.222  1.00 99.94  ? 452 GLY A N   1 
ATOM   3279 C CA  . GLY A 1 440 ? 48.894  -8.544  -6.763  1.00 102.90 ? 452 GLY A CA  1 
ATOM   3280 C C   . GLY A 1 440 ? 49.903  -9.531  -7.326  1.00 101.95 ? 452 GLY A C   1 
ATOM   3281 O O   . GLY A 1 440 ? 50.981  -9.159  -7.802  1.00 100.92 ? 452 GLY A O   1 
ATOM   3282 N N   . SER A 1 441 ? 49.567  -10.817 -7.250  1.00 100.75 ? 453 SER A N   1 
ATOM   3283 C CA  . SER A 1 441 ? 50.325  -11.819 -7.988  1.00 97.84  ? 453 SER A CA  1 
ATOM   3284 C C   . SER A 1 441 ? 49.537  -12.194 -9.235  1.00 96.49  ? 453 SER A C   1 
ATOM   3285 O O   . SER A 1 441 ? 48.376  -11.825 -9.394  1.00 93.58  ? 453 SER A O   1 
ATOM   3286 C CB  . SER A 1 441 ? 50.629  -13.059 -7.141  1.00 93.07  ? 453 SER A CB  1 
ATOM   3287 O OG  . SER A 1 441 ? 49.490  -13.519 -6.445  1.00 94.90  ? 453 SER A OG  1 
ATOM   3288 N N   . VAL A 1 442 ? 50.189  -12.903 -10.153 1.00 94.21  ? 454 VAL A N   1 
ATOM   3289 C CA  . VAL A 1 442 ? 49.473  -13.218 -11.379 1.00 90.89  ? 454 VAL A CA  1 
ATOM   3290 C C   . VAL A 1 442 ? 48.525  -14.379 -11.156 1.00 89.14  ? 454 VAL A C   1 
ATOM   3291 O O   . VAL A 1 442 ? 47.515  -14.496 -11.866 1.00 85.72  ? 454 VAL A O   1 
ATOM   3292 C CB  . VAL A 1 442 ? 50.445  -13.485 -12.539 1.00 92.00  ? 454 VAL A CB  1 
ATOM   3293 C CG1 . VAL A 1 442 ? 51.052  -14.875 -12.428 1.00 96.36  ? 454 VAL A CG1 1 
ATOM   3294 C CG2 . VAL A 1 442 ? 49.718  -13.299 -13.851 1.00 87.98  ? 454 VAL A CG2 1 
ATOM   3295 N N   . SER A 1 443 ? 48.813  -15.219 -10.160 1.00 89.83  ? 455 SER A N   1 
ATOM   3296 C CA  . SER A 1 443 ? 47.925  -16.300 -9.775  1.00 96.16  ? 455 SER A CA  1 
ATOM   3297 C C   . SER A 1 443 ? 47.015  -15.813 -8.666  1.00 93.41  ? 455 SER A C   1 
ATOM   3298 O O   . SER A 1 443 ? 47.489  -15.591 -7.541  1.00 92.14  ? 455 SER A O   1 
ATOM   3299 C CB  . SER A 1 443 ? 48.709  -17.525 -9.316  1.00 95.80  ? 455 SER A CB  1 
ATOM   3300 O OG  . SER A 1 443 ? 49.235  -18.220 -10.431 1.00 93.67  ? 455 SER A OG  1 
ATOM   3301 N N   . PRO A 1 444 ? 45.726  -15.637 -8.929  1.00 92.07  ? 456 PRO A N   1 
ATOM   3302 C CA  . PRO A 1 444 ? 44.773  -15.291 -7.876  1.00 89.31  ? 456 PRO A CA  1 
ATOM   3303 C C   . PRO A 1 444 ? 44.836  -16.286 -6.736  1.00 94.61  ? 456 PRO A C   1 
ATOM   3304 O O   . PRO A 1 444 ? 45.508  -17.326 -6.839  1.00 98.12  ? 456 PRO A O   1 
ATOM   3305 C CB  . PRO A 1 444 ? 43.415  -15.345 -8.599  1.00 83.41  ? 456 PRO A CB  1 
ATOM   3306 C CG  . PRO A 1 444 ? 43.749  -15.240 -10.033 1.00 88.60  ? 456 PRO A CG  1 
ATOM   3307 C CD  . PRO A 1 444 ? 45.069  -15.880 -10.216 1.00 90.36  ? 456 PRO A CD  1 
ATOM   3308 N N   . PRO A 1 445 ? 44.142  -16.009 -5.635  1.00 97.49  ? 457 PRO A N   1 
ATOM   3309 C CA  . PRO A 1 445 ? 44.304  -16.846 -4.444  1.00 107.47 ? 457 PRO A CA  1 
ATOM   3310 C C   . PRO A 1 445 ? 43.643  -18.209 -4.576  1.00 111.58 ? 457 PRO A C   1 
ATOM   3311 O O   . PRO A 1 445 ? 42.517  -18.340 -5.057  1.00 111.65 ? 457 PRO A O   1 
ATOM   3312 C CB  . PRO A 1 445 ? 43.661  -16.003 -3.338  1.00 110.35 ? 457 PRO A CB  1 
ATOM   3313 C CG  . PRO A 1 445 ? 42.659  -15.149 -4.030  1.00 97.78  ? 457 PRO A CG  1 
ATOM   3314 C CD  . PRO A 1 445 ? 43.147  -14.935 -5.426  1.00 95.36  ? 457 PRO A CD  1 
ATOM   3315 N N   . LEU A 1 446 ? 44.369  -19.228 -4.130  1.00 117.09 ? 458 LEU A N   1 
ATOM   3316 C CA  . LEU A 1 446 ? 43.932  -20.622 -4.164  1.00 123.25 ? 458 LEU A CA  1 
ATOM   3317 C C   . LEU A 1 446 ? 43.384  -21.114 -2.828  1.00 126.44 ? 458 LEU A C   1 
ATOM   3318 O O   . LEU A 1 446 ? 42.465  -20.527 -2.249  1.00 128.22 ? 458 LEU A O   1 
ATOM   3319 C CB  . LEU A 1 446 ? 45.097  -21.512 -4.599  1.00 124.21 ? 458 LEU A CB  1 
ATOM   3320 C CG  . LEU A 1 446 ? 45.537  -21.323 -6.043  1.00 128.16 ? 458 LEU A CG  1 
ATOM   3321 C CD1 . LEU A 1 446 ? 46.823  -22.077 -6.299  1.00 123.04 ? 458 LEU A CD1 1 
ATOM   3322 C CD2 . LEU A 1 446 ? 44.415  -21.861 -6.914  1.00 122.40 ? 458 LEU A CD2 1 
ATOM   3323 O OXT . LEU A 1 446 ? 43.838  -22.130 -2.297  1.00 120.72 ? 458 LEU A OXT 1 
HETATM 3324 C C1  . NAG B 2 .   ? -12.793 -33.922 -24.121 1.00 102.18 ? 501 NAG A C1  1 
HETATM 3325 C C2  . NAG B 2 .   ? -13.495 -32.568 -24.210 1.00 95.69  ? 501 NAG A C2  1 
HETATM 3326 C C3  . NAG B 2 .   ? -13.778 -32.034 -22.813 1.00 100.51 ? 501 NAG A C3  1 
HETATM 3327 C C4  . NAG B 2 .   ? -14.653 -33.024 -22.067 1.00 96.58  ? 501 NAG A C4  1 
HETATM 3328 C C5  . NAG B 2 .   ? -13.898 -34.355 -21.996 1.00 103.99 ? 501 NAG A C5  1 
HETATM 3329 C C6  . NAG B 2 .   ? -14.655 -35.444 -21.273 1.00 107.30 ? 501 NAG A C6  1 
HETATM 3330 C C7  . NAG B 2 .   ? -13.120 -31.167 -26.161 1.00 101.17 ? 501 NAG A C7  1 
HETATM 3331 C C8  . NAG B 2 .   ? -12.236 -30.172 -26.821 1.00 112.37 ? 501 NAG A C8  1 
HETATM 3332 N N2  . NAG B 2 .   ? -12.719 -31.608 -24.970 1.00 92.53  ? 501 NAG A N2  1 
HETATM 3333 O O3  . NAG B 2 .   ? -14.376 -30.742 -22.839 1.00 108.86 ? 501 NAG A O3  1 
HETATM 3334 O O4  . NAG B 2 .   ? -14.999 -32.494 -20.787 1.00 86.99  ? 501 NAG A O4  1 
HETATM 3335 O O5  . NAG B 2 .   ? -13.604 -34.842 -23.322 1.00 101.69 ? 501 NAG A O5  1 
HETATM 3336 O O6  . NAG B 2 .   ? -15.193 -34.958 -20.049 1.00 104.72 ? 501 NAG A O6  1 
HETATM 3337 O O7  . NAG B 2 .   ? -14.147 -31.570 -26.688 1.00 107.09 ? 501 NAG A O7  1 
# 
