data_8JBS
# 
_entry.id   8JBS 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8JBS         pdb_00008jbs 10.2210/pdb8jbs/pdb 
WWPDB D_1300037504 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2024-11-13 
2 'Structure model' 1 1 2025-01-29 
3 'Structure model' 1 2 2025-02-19 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' 'Database references' 
2 3 'Structure model' 'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
3 3 'Structure model' citation        
4 3 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  2 'Structure model' '_citation.country'                 
2  2 'Structure model' '_citation.journal_abbrev'          
3  2 'Structure model' '_citation.journal_id_CSD'          
4  2 'Structure model' '_citation.journal_id_ISSN'         
5  2 'Structure model' '_citation.pdbx_database_id_DOI'    
6  2 'Structure model' '_citation.pdbx_database_id_PubMed' 
7  2 'Structure model' '_citation.title'                   
8  2 'Structure model' '_citation.year'                    
9  2 'Structure model' '_citation_author.identifier_ORCID' 
10 3 'Structure model' '_citation.journal_volume'          
11 3 'Structure model' '_citation.page_first'              
12 3 'Structure model' '_citation.page_last'               
13 3 'Structure model' '_citation.year'                    
14 3 'Structure model' '_citation_author.identifier_ORCID' 
# 
loop_
_database_PDB_caveat.id 
_database_PDB_caveat.text 
1 'B12 A 301 HAS WRONG CHIRALITY AT ATOM C19' 
2 'B12 B 301 HAS WRONG CHIRALITY AT ATOM C19' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8JBS 
_pdbx_database_status.recvd_initial_deposition_date   2023-05-09 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              shaowei.zhang1123@hotmail.com 
_pdbx_contact_author.name_first         Shaowei 
_pdbx_contact_author.name_last          Zhang 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-9763-3266 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Zhang, S.' 1 ? 
'Yu, Y.'    2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Febs J.' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1742-464X 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            292 
_citation.language                  ? 
_citation.page_first                635 
_citation.page_last                 652 
_citation.title                     
'SignatureFinder enables sequence mining to identify cobalamin-dependent photoreceptor proteins.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1111/febs.17377 
_citation.pdbx_database_id_PubMed   39718193 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Yu, Y.'          1  ? 
primary 'Jeffreys, L.N.'  2  ? 
primary 'Poddar, H.'      3  ? 
primary 'Hill, A.'        4  ? 
primary 'Johannissen, L.' 5  ? 
primary 'Dai, F.'         6  ? 
primary 'Sakuma, M.'      7  ? 
primary 'Leys, D.'        8  ? 
primary 'Heyes, D.J.'     9  ? 
primary 'Zhang, S.'       10 ? 
primary 'Scrutton, N.S.'  11 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Putative cobalamin binding protein' 36124.918 2  ? ? 'B12-binding domain' ? 
2 non-polymer syn COBALAMIN                            1330.356  2  ? ? ?                    ? 
3 non-polymer syn "5'-DEOXYADENOSINE"                  251.242   2  ? ? ?                    ? 
4 water       nat water                                18.015    37 ? ? ?                    ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MPRSKHTIQPVTTAQQTYSTAEVARMWAVSESSVKRWSDSGALSCIRTPGGHRRFTLQALLDFQRAGGVLRHGGQPGSGA
VSVVSDGAAAVTASLDQALVARDWAALQARYYEAAVAGDELAGVALLERAYRSGIPVVALKEHVLTPVLHLIGERWRRGE
LNIWEEHLASQVTLAATEHLHRQLPRAPFNGRLALCGCPEGDLHEIALHLVMEVLEVEGWRVLSLGPNTPLFSFADAVRR
FSPQLVCISATIVHDLERLRRDYGDFYHTVRQHGARIVIGGAAFADPQVREIFIHDYQAAGLTDFLDYLRREFPTPAVAT
GHHHHHH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MPRSKHTIQPVTTAQQTYSTAEVARMWAVSESSVKRWSDSGALSCIRTPGGHRRFTLQALLDFQRAGGVLRHGGQPGSGA
VSVVSDGAAAVTASLDQALVARDWAALQARYYEAAVAGDELAGVALLERAYRSGIPVVALKEHVLTPVLHLIGERWRRGE
LNIWEEHLASQVTLAATEHLHRQLPRAPFNGRLALCGCPEGDLHEIALHLVMEVLEVEGWRVLSLGPNTPLFSFADAVRR
FSPQLVCISATIVHDLERLRRDYGDFYHTVRQHGARIVIGGAAFADPQVREIFIHDYQAAGLTDFLDYLRREFPTPAVAT
GHHHHHH
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 COBALAMIN           B12 
3 "5'-DEOXYADENOSINE" 5AD 
4 water               HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   PRO n 
1 3   ARG n 
1 4   SER n 
1 5   LYS n 
1 6   HIS n 
1 7   THR n 
1 8   ILE n 
1 9   GLN n 
1 10  PRO n 
1 11  VAL n 
1 12  THR n 
1 13  THR n 
1 14  ALA n 
1 15  GLN n 
1 16  GLN n 
1 17  THR n 
1 18  TYR n 
1 19  SER n 
1 20  THR n 
1 21  ALA n 
1 22  GLU n 
1 23  VAL n 
1 24  ALA n 
1 25  ARG n 
1 26  MET n 
1 27  TRP n 
1 28  ALA n 
1 29  VAL n 
1 30  SER n 
1 31  GLU n 
1 32  SER n 
1 33  SER n 
1 34  VAL n 
1 35  LYS n 
1 36  ARG n 
1 37  TRP n 
1 38  SER n 
1 39  ASP n 
1 40  SER n 
1 41  GLY n 
1 42  ALA n 
1 43  LEU n 
1 44  SER n 
1 45  CYS n 
1 46  ILE n 
1 47  ARG n 
1 48  THR n 
1 49  PRO n 
1 50  GLY n 
1 51  GLY n 
1 52  HIS n 
1 53  ARG n 
1 54  ARG n 
1 55  PHE n 
1 56  THR n 
1 57  LEU n 
1 58  GLN n 
1 59  ALA n 
1 60  LEU n 
1 61  LEU n 
1 62  ASP n 
1 63  PHE n 
1 64  GLN n 
1 65  ARG n 
1 66  ALA n 
1 67  GLY n 
1 68  GLY n 
1 69  VAL n 
1 70  LEU n 
1 71  ARG n 
1 72  HIS n 
1 73  GLY n 
1 74  GLY n 
1 75  GLN n 
1 76  PRO n 
1 77  GLY n 
1 78  SER n 
1 79  GLY n 
1 80  ALA n 
1 81  VAL n 
1 82  SER n 
1 83  VAL n 
1 84  VAL n 
1 85  SER n 
1 86  ASP n 
1 87  GLY n 
1 88  ALA n 
1 89  ALA n 
1 90  ALA n 
1 91  VAL n 
1 92  THR n 
1 93  ALA n 
1 94  SER n 
1 95  LEU n 
1 96  ASP n 
1 97  GLN n 
1 98  ALA n 
1 99  LEU n 
1 100 VAL n 
1 101 ALA n 
1 102 ARG n 
1 103 ASP n 
1 104 TRP n 
1 105 ALA n 
1 106 ALA n 
1 107 LEU n 
1 108 GLN n 
1 109 ALA n 
1 110 ARG n 
1 111 TYR n 
1 112 TYR n 
1 113 GLU n 
1 114 ALA n 
1 115 ALA n 
1 116 VAL n 
1 117 ALA n 
1 118 GLY n 
1 119 ASP n 
1 120 GLU n 
1 121 LEU n 
1 122 ALA n 
1 123 GLY n 
1 124 VAL n 
1 125 ALA n 
1 126 LEU n 
1 127 LEU n 
1 128 GLU n 
1 129 ARG n 
1 130 ALA n 
1 131 TYR n 
1 132 ARG n 
1 133 SER n 
1 134 GLY n 
1 135 ILE n 
1 136 PRO n 
1 137 VAL n 
1 138 VAL n 
1 139 ALA n 
1 140 LEU n 
1 141 LYS n 
1 142 GLU n 
1 143 HIS n 
1 144 VAL n 
1 145 LEU n 
1 146 THR n 
1 147 PRO n 
1 148 VAL n 
1 149 LEU n 
1 150 HIS n 
1 151 LEU n 
1 152 ILE n 
1 153 GLY n 
1 154 GLU n 
1 155 ARG n 
1 156 TRP n 
1 157 ARG n 
1 158 ARG n 
1 159 GLY n 
1 160 GLU n 
1 161 LEU n 
1 162 ASN n 
1 163 ILE n 
1 164 TRP n 
1 165 GLU n 
1 166 GLU n 
1 167 HIS n 
1 168 LEU n 
1 169 ALA n 
1 170 SER n 
1 171 GLN n 
1 172 VAL n 
1 173 THR n 
1 174 LEU n 
1 175 ALA n 
1 176 ALA n 
1 177 THR n 
1 178 GLU n 
1 179 HIS n 
1 180 LEU n 
1 181 HIS n 
1 182 ARG n 
1 183 GLN n 
1 184 LEU n 
1 185 PRO n 
1 186 ARG n 
1 187 ALA n 
1 188 PRO n 
1 189 PHE n 
1 190 ASN n 
1 191 GLY n 
1 192 ARG n 
1 193 LEU n 
1 194 ALA n 
1 195 LEU n 
1 196 CYS n 
1 197 GLY n 
1 198 CYS n 
1 199 PRO n 
1 200 GLU n 
1 201 GLY n 
1 202 ASP n 
1 203 LEU n 
1 204 HIS n 
1 205 GLU n 
1 206 ILE n 
1 207 ALA n 
1 208 LEU n 
1 209 HIS n 
1 210 LEU n 
1 211 VAL n 
1 212 MET n 
1 213 GLU n 
1 214 VAL n 
1 215 LEU n 
1 216 GLU n 
1 217 VAL n 
1 218 GLU n 
1 219 GLY n 
1 220 TRP n 
1 221 ARG n 
1 222 VAL n 
1 223 LEU n 
1 224 SER n 
1 225 LEU n 
1 226 GLY n 
1 227 PRO n 
1 228 ASN n 
1 229 THR n 
1 230 PRO n 
1 231 LEU n 
1 232 PHE n 
1 233 SER n 
1 234 PHE n 
1 235 ALA n 
1 236 ASP n 
1 237 ALA n 
1 238 VAL n 
1 239 ARG n 
1 240 ARG n 
1 241 PHE n 
1 242 SER n 
1 243 PRO n 
1 244 GLN n 
1 245 LEU n 
1 246 VAL n 
1 247 CYS n 
1 248 ILE n 
1 249 SER n 
1 250 ALA n 
1 251 THR n 
1 252 ILE n 
1 253 VAL n 
1 254 HIS n 
1 255 ASP n 
1 256 LEU n 
1 257 GLU n 
1 258 ARG n 
1 259 LEU n 
1 260 ARG n 
1 261 ARG n 
1 262 ASP n 
1 263 TYR n 
1 264 GLY n 
1 265 ASP n 
1 266 PHE n 
1 267 TYR n 
1 268 HIS n 
1 269 THR n 
1 270 VAL n 
1 271 ARG n 
1 272 GLN n 
1 273 HIS n 
1 274 GLY n 
1 275 ALA n 
1 276 ARG n 
1 277 ILE n 
1 278 VAL n 
1 279 ILE n 
1 280 GLY n 
1 281 GLY n 
1 282 ALA n 
1 283 ALA n 
1 284 PHE n 
1 285 ALA n 
1 286 ASP n 
1 287 PRO n 
1 288 GLN n 
1 289 VAL n 
1 290 ARG n 
1 291 GLU n 
1 292 ILE n 
1 293 PHE n 
1 294 ILE n 
1 295 HIS n 
1 296 ASP n 
1 297 TYR n 
1 298 GLN n 
1 299 ALA n 
1 300 ALA n 
1 301 GLY n 
1 302 LEU n 
1 303 THR n 
1 304 ASP n 
1 305 PHE n 
1 306 LEU n 
1 307 ASP n 
1 308 TYR n 
1 309 LEU n 
1 310 ARG n 
1 311 ARG n 
1 312 GLU n 
1 313 PHE n 
1 314 PRO n 
1 315 THR n 
1 316 PRO n 
1 317 ALA n 
1 318 VAL n 
1 319 ALA n 
1 320 THR n 
1 321 GLY n 
1 322 HIS n 
1 323 HIS n 
1 324 HIS n 
1 325 HIS n 
1 326 HIS n 
1 327 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   327 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Chloracidobacterium thermophilum' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     458033 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
5AD non-polymer         . "5'-DEOXYADENOSINE" ? 'C10 H13 N5 O3'          251.242  
ALA 'L-peptide linking' y ALANINE             ? 'C3 H7 N O2'             89.093   
ARG 'L-peptide linking' y ARGININE            ? 'C6 H15 N4 O2 1'         175.209  
ASN 'L-peptide linking' y ASPARAGINE          ? 'C4 H8 N2 O3'            132.118  
ASP 'L-peptide linking' y 'ASPARTIC ACID'     ? 'C4 H7 N O4'             133.103  
B12 non-polymer         . COBALAMIN           ? 'C62 H89 Co N13 O14 P 2' 1330.356 
CYS 'L-peptide linking' y CYSTEINE            ? 'C3 H7 N O2 S'           121.158  
GLN 'L-peptide linking' y GLUTAMINE           ? 'C5 H10 N2 O3'           146.144  
GLU 'L-peptide linking' y 'GLUTAMIC ACID'     ? 'C5 H9 N O4'             147.129  
GLY 'peptide linking'   y GLYCINE             ? 'C2 H5 N O2'             75.067   
HIS 'L-peptide linking' y HISTIDINE           ? 'C6 H10 N3 O2 1'         156.162  
HOH non-polymer         . WATER               ? 'H2 O'                   18.015   
ILE 'L-peptide linking' y ISOLEUCINE          ? 'C6 H13 N O2'            131.173  
LEU 'L-peptide linking' y LEUCINE             ? 'C6 H13 N O2'            131.173  
LYS 'L-peptide linking' y LYSINE              ? 'C6 H15 N2 O2 1'         147.195  
MET 'L-peptide linking' y METHIONINE          ? 'C5 H11 N O2 S'          149.211  
PHE 'L-peptide linking' y PHENYLALANINE       ? 'C9 H11 N O2'            165.189  
PRO 'L-peptide linking' y PROLINE             ? 'C5 H9 N O2'             115.130  
SER 'L-peptide linking' y SERINE              ? 'C3 H7 N O3'             105.093  
THR 'L-peptide linking' y THREONINE           ? 'C4 H9 N O3'             119.119  
TRP 'L-peptide linking' y TRYPTOPHAN          ? 'C11 H12 N2 O2'          204.225  
TYR 'L-peptide linking' y TYROSINE            ? 'C9 H11 N O3'            181.189  
VAL 'L-peptide linking' y VALINE              ? 'C5 H11 N O2'            117.146  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -81 ?   ?   ?   A . n 
A 1 2   PRO 2   -80 ?   ?   ?   A . n 
A 1 3   ARG 3   -79 ?   ?   ?   A . n 
A 1 4   SER 4   -78 ?   ?   ?   A . n 
A 1 5   LYS 5   -77 ?   ?   ?   A . n 
A 1 6   HIS 6   -76 ?   ?   ?   A . n 
A 1 7   THR 7   -75 ?   ?   ?   A . n 
A 1 8   ILE 8   -74 ?   ?   ?   A . n 
A 1 9   GLN 9   -73 ?   ?   ?   A . n 
A 1 10  PRO 10  -72 ?   ?   ?   A . n 
A 1 11  VAL 11  -71 ?   ?   ?   A . n 
A 1 12  THR 12  -70 ?   ?   ?   A . n 
A 1 13  THR 13  -69 ?   ?   ?   A . n 
A 1 14  ALA 14  -68 ?   ?   ?   A . n 
A 1 15  GLN 15  -67 ?   ?   ?   A . n 
A 1 16  GLN 16  -66 ?   ?   ?   A . n 
A 1 17  THR 17  -65 ?   ?   ?   A . n 
A 1 18  TYR 18  -64 ?   ?   ?   A . n 
A 1 19  SER 19  -63 ?   ?   ?   A . n 
A 1 20  THR 20  -62 ?   ?   ?   A . n 
A 1 21  ALA 21  -61 ?   ?   ?   A . n 
A 1 22  GLU 22  -60 ?   ?   ?   A . n 
A 1 23  VAL 23  -59 ?   ?   ?   A . n 
A 1 24  ALA 24  -58 ?   ?   ?   A . n 
A 1 25  ARG 25  -57 ?   ?   ?   A . n 
A 1 26  MET 26  -56 ?   ?   ?   A . n 
A 1 27  TRP 27  -55 ?   ?   ?   A . n 
A 1 28  ALA 28  -54 ?   ?   ?   A . n 
A 1 29  VAL 29  -53 ?   ?   ?   A . n 
A 1 30  SER 30  -52 ?   ?   ?   A . n 
A 1 31  GLU 31  -51 ?   ?   ?   A . n 
A 1 32  SER 32  -50 ?   ?   ?   A . n 
A 1 33  SER 33  -49 ?   ?   ?   A . n 
A 1 34  VAL 34  -48 ?   ?   ?   A . n 
A 1 35  LYS 35  -47 ?   ?   ?   A . n 
A 1 36  ARG 36  -46 ?   ?   ?   A . n 
A 1 37  TRP 37  -45 ?   ?   ?   A . n 
A 1 38  SER 38  -44 ?   ?   ?   A . n 
A 1 39  ASP 39  -43 ?   ?   ?   A . n 
A 1 40  SER 40  -42 ?   ?   ?   A . n 
A 1 41  GLY 41  -41 ?   ?   ?   A . n 
A 1 42  ALA 42  -40 ?   ?   ?   A . n 
A 1 43  LEU 43  -39 ?   ?   ?   A . n 
A 1 44  SER 44  -38 ?   ?   ?   A . n 
A 1 45  CYS 45  -37 ?   ?   ?   A . n 
A 1 46  ILE 46  -36 ?   ?   ?   A . n 
A 1 47  ARG 47  -35 ?   ?   ?   A . n 
A 1 48  THR 48  -34 ?   ?   ?   A . n 
A 1 49  PRO 49  -33 ?   ?   ?   A . n 
A 1 50  GLY 50  -32 ?   ?   ?   A . n 
A 1 51  GLY 51  -31 ?   ?   ?   A . n 
A 1 52  HIS 52  -30 ?   ?   ?   A . n 
A 1 53  ARG 53  -29 ?   ?   ?   A . n 
A 1 54  ARG 54  -28 ?   ?   ?   A . n 
A 1 55  PHE 55  -27 ?   ?   ?   A . n 
A 1 56  THR 56  -26 ?   ?   ?   A . n 
A 1 57  LEU 57  -25 ?   ?   ?   A . n 
A 1 58  GLN 58  -24 ?   ?   ?   A . n 
A 1 59  ALA 59  -23 ?   ?   ?   A . n 
A 1 60  LEU 60  -22 ?   ?   ?   A . n 
A 1 61  LEU 61  -21 ?   ?   ?   A . n 
A 1 62  ASP 62  -20 ?   ?   ?   A . n 
A 1 63  PHE 63  -19 ?   ?   ?   A . n 
A 1 64  GLN 64  -18 ?   ?   ?   A . n 
A 1 65  ARG 65  -17 ?   ?   ?   A . n 
A 1 66  ALA 66  -16 ?   ?   ?   A . n 
A 1 67  GLY 67  -15 ?   ?   ?   A . n 
A 1 68  GLY 68  -14 ?   ?   ?   A . n 
A 1 69  VAL 69  -13 ?   ?   ?   A . n 
A 1 70  LEU 70  -12 ?   ?   ?   A . n 
A 1 71  ARG 71  -11 ?   ?   ?   A . n 
A 1 72  HIS 72  -10 ?   ?   ?   A . n 
A 1 73  GLY 73  -9  ?   ?   ?   A . n 
A 1 74  GLY 74  -8  ?   ?   ?   A . n 
A 1 75  GLN 75  -7  ?   ?   ?   A . n 
A 1 76  PRO 76  -6  ?   ?   ?   A . n 
A 1 77  GLY 77  -5  ?   ?   ?   A . n 
A 1 78  SER 78  -4  ?   ?   ?   A . n 
A 1 79  GLY 79  -3  ?   ?   ?   A . n 
A 1 80  ALA 80  -2  ?   ?   ?   A . n 
A 1 81  VAL 81  -1  ?   ?   ?   A . n 
A 1 82  SER 82  0   ?   ?   ?   A . n 
A 1 83  VAL 83  1   ?   ?   ?   A . n 
A 1 84  VAL 84  2   ?   ?   ?   A . n 
A 1 85  SER 85  3   ?   ?   ?   A . n 
A 1 86  ASP 86  4   ?   ?   ?   A . n 
A 1 87  GLY 87  5   ?   ?   ?   A . n 
A 1 88  ALA 88  6   ?   ?   ?   A . n 
A 1 89  ALA 89  7   ?   ?   ?   A . n 
A 1 90  ALA 90  8   ?   ?   ?   A . n 
A 1 91  VAL 91  9   9   VAL VAL A . n 
A 1 92  THR 92  10  10  THR THR A . n 
A 1 93  ALA 93  11  11  ALA ALA A . n 
A 1 94  SER 94  12  12  SER SER A . n 
A 1 95  LEU 95  13  13  LEU LEU A . n 
A 1 96  ASP 96  14  14  ASP ASP A . n 
A 1 97  GLN 97  15  15  GLN GLN A . n 
A 1 98  ALA 98  16  16  ALA ALA A . n 
A 1 99  LEU 99  17  17  LEU LEU A . n 
A 1 100 VAL 100 18  18  VAL VAL A . n 
A 1 101 ALA 101 19  19  ALA ALA A . n 
A 1 102 ARG 102 20  20  ARG ARG A . n 
A 1 103 ASP 103 21  21  ASP ASP A . n 
A 1 104 TRP 104 22  22  TRP TRP A . n 
A 1 105 ALA 105 23  23  ALA ALA A . n 
A 1 106 ALA 106 24  24  ALA ALA A . n 
A 1 107 LEU 107 25  25  LEU LEU A . n 
A 1 108 GLN 108 26  26  GLN GLN A . n 
A 1 109 ALA 109 27  27  ALA ALA A . n 
A 1 110 ARG 110 28  28  ARG ARG A . n 
A 1 111 TYR 111 29  29  TYR TYR A . n 
A 1 112 TYR 112 30  30  TYR TYR A . n 
A 1 113 GLU 113 31  31  GLU GLU A . n 
A 1 114 ALA 114 32  32  ALA ALA A . n 
A 1 115 ALA 115 33  33  ALA ALA A . n 
A 1 116 VAL 116 34  34  VAL VAL A . n 
A 1 117 ALA 117 35  35  ALA ALA A . n 
A 1 118 GLY 118 36  36  GLY GLY A . n 
A 1 119 ASP 119 37  37  ASP ASP A . n 
A 1 120 GLU 120 38  38  GLU GLU A . n 
A 1 121 LEU 121 39  39  LEU LEU A . n 
A 1 122 ALA 122 40  40  ALA ALA A . n 
A 1 123 GLY 123 41  41  GLY GLY A . n 
A 1 124 VAL 124 42  42  VAL VAL A . n 
A 1 125 ALA 125 43  43  ALA ALA A . n 
A 1 126 LEU 126 44  44  LEU LEU A . n 
A 1 127 LEU 127 45  45  LEU LEU A . n 
A 1 128 GLU 128 46  46  GLU GLU A . n 
A 1 129 ARG 129 47  47  ARG ARG A . n 
A 1 130 ALA 130 48  48  ALA ALA A . n 
A 1 131 TYR 131 49  49  TYR TYR A . n 
A 1 132 ARG 132 50  50  ARG ARG A . n 
A 1 133 SER 133 51  51  SER SER A . n 
A 1 134 GLY 134 52  52  GLY GLY A . n 
A 1 135 ILE 135 53  53  ILE ILE A . n 
A 1 136 PRO 136 54  54  PRO PRO A . n 
A 1 137 VAL 137 55  55  VAL VAL A . n 
A 1 138 VAL 138 56  56  VAL VAL A . n 
A 1 139 ALA 139 57  57  ALA ALA A . n 
A 1 140 LEU 140 58  58  LEU LEU A . n 
A 1 141 LYS 141 59  59  LYS LYS A . n 
A 1 142 GLU 142 60  60  GLU GLU A . n 
A 1 143 HIS 143 61  61  HIS HIS A . n 
A 1 144 VAL 144 62  62  VAL VAL A . n 
A 1 145 LEU 145 63  63  LEU LEU A . n 
A 1 146 THR 146 64  64  THR THR A . n 
A 1 147 PRO 147 65  65  PRO PRO A . n 
A 1 148 VAL 148 66  66  VAL VAL A . n 
A 1 149 LEU 149 67  67  LEU LEU A . n 
A 1 150 HIS 150 68  68  HIS HIS A . n 
A 1 151 LEU 151 69  69  LEU LEU A . n 
A 1 152 ILE 152 70  70  ILE ILE A . n 
A 1 153 GLY 153 71  71  GLY GLY A . n 
A 1 154 GLU 154 72  72  GLU GLU A . n 
A 1 155 ARG 155 73  73  ARG ARG A . n 
A 1 156 TRP 156 74  74  TRP TRP A . n 
A 1 157 ARG 157 75  75  ARG ARG A . n 
A 1 158 ARG 158 76  76  ARG ARG A . n 
A 1 159 GLY 159 77  77  GLY GLY A . n 
A 1 160 GLU 160 78  78  GLU GLU A . n 
A 1 161 LEU 161 79  79  LEU LEU A . n 
A 1 162 ASN 162 80  80  ASN ASN A . n 
A 1 163 ILE 163 81  81  ILE ILE A . n 
A 1 164 TRP 164 82  82  TRP TRP A . n 
A 1 165 GLU 165 83  83  GLU GLU A . n 
A 1 166 GLU 166 84  84  GLU GLU A . n 
A 1 167 HIS 167 85  85  HIS HIS A . n 
A 1 168 LEU 168 86  86  LEU LEU A . n 
A 1 169 ALA 169 87  87  ALA ALA A . n 
A 1 170 SER 170 88  88  SER SER A . n 
A 1 171 GLN 171 89  89  GLN GLN A . n 
A 1 172 VAL 172 90  90  VAL VAL A . n 
A 1 173 THR 173 91  91  THR THR A . n 
A 1 174 LEU 174 92  92  LEU LEU A . n 
A 1 175 ALA 175 93  93  ALA ALA A . n 
A 1 176 ALA 176 94  94  ALA ALA A . n 
A 1 177 THR 177 95  95  THR THR A . n 
A 1 178 GLU 178 96  96  GLU GLU A . n 
A 1 179 HIS 179 97  97  HIS HIS A . n 
A 1 180 LEU 180 98  98  LEU LEU A . n 
A 1 181 HIS 181 99  99  HIS HIS A . n 
A 1 182 ARG 182 100 100 ARG ARG A . n 
A 1 183 GLN 183 101 101 GLN GLN A . n 
A 1 184 LEU 184 102 102 LEU LEU A . n 
A 1 185 PRO 185 103 103 PRO PRO A . n 
A 1 186 ARG 186 104 104 ARG ARG A . n 
A 1 187 ALA 187 105 105 ALA ALA A . n 
A 1 188 PRO 188 106 106 PRO PRO A . n 
A 1 189 PHE 189 107 107 PHE PHE A . n 
A 1 190 ASN 190 108 108 ASN ASN A . n 
A 1 191 GLY 191 109 109 GLY GLY A . n 
A 1 192 ARG 192 110 110 ARG ARG A . n 
A 1 193 LEU 193 111 111 LEU LEU A . n 
A 1 194 ALA 194 112 112 ALA ALA A . n 
A 1 195 LEU 195 113 113 LEU LEU A . n 
A 1 196 CYS 196 114 114 CYS CYS A . n 
A 1 197 GLY 197 115 115 GLY GLY A . n 
A 1 198 CYS 198 116 116 CYS CYS A . n 
A 1 199 PRO 199 117 117 PRO PRO A . n 
A 1 200 GLU 200 118 118 GLU GLU A . n 
A 1 201 GLY 201 119 119 GLY GLY A . n 
A 1 202 ASP 202 120 120 ASP ASP A . n 
A 1 203 LEU 203 121 121 LEU LEU A . n 
A 1 204 HIS 204 122 122 HIS HIS A . n 
A 1 205 GLU 205 123 123 GLU GLU A . n 
A 1 206 ILE 206 124 124 ILE ILE A . n 
A 1 207 ALA 207 125 125 ALA ALA A . n 
A 1 208 LEU 208 126 126 LEU LEU A . n 
A 1 209 HIS 209 127 127 HIS HIS A . n 
A 1 210 LEU 210 128 128 LEU LEU A . n 
A 1 211 VAL 211 129 129 VAL VAL A . n 
A 1 212 MET 212 130 130 MET MET A . n 
A 1 213 GLU 213 131 131 GLU GLU A . n 
A 1 214 VAL 214 132 132 VAL VAL A . n 
A 1 215 LEU 215 133 133 LEU LEU A . n 
A 1 216 GLU 216 134 134 GLU GLU A . n 
A 1 217 VAL 217 135 135 VAL VAL A . n 
A 1 218 GLU 218 136 136 GLU GLU A . n 
A 1 219 GLY 219 137 137 GLY GLY A . n 
A 1 220 TRP 220 138 138 TRP TRP A . n 
A 1 221 ARG 221 139 139 ARG ARG A . n 
A 1 222 VAL 222 140 140 VAL VAL A . n 
A 1 223 LEU 223 141 141 LEU LEU A . n 
A 1 224 SER 224 142 142 SER SER A . n 
A 1 225 LEU 225 143 143 LEU LEU A . n 
A 1 226 GLY 226 144 144 GLY GLY A . n 
A 1 227 PRO 227 145 145 PRO PRO A . n 
A 1 228 ASN 228 146 146 ASN ASN A . n 
A 1 229 THR 229 147 147 THR THR A . n 
A 1 230 PRO 230 148 148 PRO PRO A . n 
A 1 231 LEU 231 149 149 LEU LEU A . n 
A 1 232 PHE 232 150 150 PHE PHE A . n 
A 1 233 SER 233 151 151 SER SER A . n 
A 1 234 PHE 234 152 152 PHE PHE A . n 
A 1 235 ALA 235 153 153 ALA ALA A . n 
A 1 236 ASP 236 154 154 ASP ASP A . n 
A 1 237 ALA 237 155 155 ALA ALA A . n 
A 1 238 VAL 238 156 156 VAL VAL A . n 
A 1 239 ARG 239 157 157 ARG ARG A . n 
A 1 240 ARG 240 158 158 ARG ARG A . n 
A 1 241 PHE 241 159 159 PHE PHE A . n 
A 1 242 SER 242 160 160 SER SER A . n 
A 1 243 PRO 243 161 161 PRO PRO A . n 
A 1 244 GLN 244 162 162 GLN GLN A . n 
A 1 245 LEU 245 163 163 LEU LEU A . n 
A 1 246 VAL 246 164 164 VAL VAL A . n 
A 1 247 CYS 247 165 165 CYS CYS A . n 
A 1 248 ILE 248 166 166 ILE ILE A . n 
A 1 249 SER 249 167 167 SER SER A . n 
A 1 250 ALA 250 168 168 ALA ALA A . n 
A 1 251 THR 251 169 169 THR THR A . n 
A 1 252 ILE 252 170 170 ILE ILE A . n 
A 1 253 VAL 253 171 171 VAL VAL A . n 
A 1 254 HIS 254 172 172 HIS HIS A . n 
A 1 255 ASP 255 173 173 ASP ASP A . n 
A 1 256 LEU 256 174 174 LEU LEU A . n 
A 1 257 GLU 257 175 175 GLU GLU A . n 
A 1 258 ARG 258 176 176 ARG ARG A . n 
A 1 259 LEU 259 177 177 LEU LEU A . n 
A 1 260 ARG 260 178 178 ARG ARG A . n 
A 1 261 ARG 261 179 179 ARG ARG A . n 
A 1 262 ASP 262 180 180 ASP ASP A . n 
A 1 263 TYR 263 181 181 TYR TYR A . n 
A 1 264 GLY 264 182 182 GLY GLY A . n 
A 1 265 ASP 265 183 183 ASP ASP A . n 
A 1 266 PHE 266 184 184 PHE PHE A . n 
A 1 267 TYR 267 185 185 TYR TYR A . n 
A 1 268 HIS 268 186 186 HIS HIS A . n 
A 1 269 THR 269 187 187 THR THR A . n 
A 1 270 VAL 270 188 188 VAL VAL A . n 
A 1 271 ARG 271 189 189 ARG ARG A . n 
A 1 272 GLN 272 190 190 GLN GLN A . n 
A 1 273 HIS 273 191 191 HIS HIS A . n 
A 1 274 GLY 274 192 192 GLY GLY A . n 
A 1 275 ALA 275 193 193 ALA ALA A . n 
A 1 276 ARG 276 194 194 ARG ARG A . n 
A 1 277 ILE 277 195 195 ILE ILE A . n 
A 1 278 VAL 278 196 196 VAL VAL A . n 
A 1 279 ILE 279 197 197 ILE ILE A . n 
A 1 280 GLY 280 198 198 GLY GLY A . n 
A 1 281 GLY 281 199 199 GLY GLY A . n 
A 1 282 ALA 282 200 200 ALA ALA A . n 
A 1 283 ALA 283 201 201 ALA ALA A . n 
A 1 284 PHE 284 202 202 PHE PHE A . n 
A 1 285 ALA 285 203 203 ALA ALA A . n 
A 1 286 ASP 286 204 204 ASP ASP A . n 
A 1 287 PRO 287 205 205 PRO PRO A . n 
A 1 288 GLN 288 206 206 GLN GLN A . n 
A 1 289 VAL 289 207 207 VAL VAL A . n 
A 1 290 ARG 290 208 208 ARG ARG A . n 
A 1 291 GLU 291 209 209 GLU GLU A . n 
A 1 292 ILE 292 210 210 ILE ILE A . n 
A 1 293 PHE 293 211 211 PHE PHE A . n 
A 1 294 ILE 294 212 212 ILE ILE A . n 
A 1 295 HIS 295 213 213 HIS HIS A . n 
A 1 296 ASP 296 214 214 ASP ASP A . n 
A 1 297 TYR 297 215 215 TYR TYR A . n 
A 1 298 GLN 298 216 216 GLN GLN A . n 
A 1 299 ALA 299 217 217 ALA ALA A . n 
A 1 300 ALA 300 218 218 ALA ALA A . n 
A 1 301 GLY 301 219 219 GLY GLY A . n 
A 1 302 LEU 302 220 220 LEU LEU A . n 
A 1 303 THR 303 221 221 THR THR A . n 
A 1 304 ASP 304 222 222 ASP ASP A . n 
A 1 305 PHE 305 223 223 PHE PHE A . n 
A 1 306 LEU 306 224 224 LEU LEU A . n 
A 1 307 ASP 307 225 225 ASP ASP A . n 
A 1 308 TYR 308 226 226 TYR TYR A . n 
A 1 309 LEU 309 227 227 LEU LEU A . n 
A 1 310 ARG 310 228 228 ARG ARG A . n 
A 1 311 ARG 311 229 229 ARG ARG A . n 
A 1 312 GLU 312 230 230 GLU GLU A . n 
A 1 313 PHE 313 231 231 PHE PHE A . n 
A 1 314 PRO 314 232 232 PRO PRO A . n 
A 1 315 THR 315 233 233 THR THR A . n 
A 1 316 PRO 316 234 234 PRO PRO A . n 
A 1 317 ALA 317 235 235 ALA ALA A . n 
A 1 318 VAL 318 236 ?   ?   ?   A . n 
A 1 319 ALA 319 237 ?   ?   ?   A . n 
A 1 320 THR 320 238 ?   ?   ?   A . n 
A 1 321 GLY 321 239 ?   ?   ?   A . n 
A 1 322 HIS 322 240 ?   ?   ?   A . n 
A 1 323 HIS 323 241 ?   ?   ?   A . n 
A 1 324 HIS 324 242 ?   ?   ?   A . n 
A 1 325 HIS 325 243 ?   ?   ?   A . n 
A 1 326 HIS 326 244 ?   ?   ?   A . n 
A 1 327 HIS 327 245 ?   ?   ?   A . n 
B 1 1   MET 1   -81 ?   ?   ?   B . n 
B 1 2   PRO 2   -80 ?   ?   ?   B . n 
B 1 3   ARG 3   -79 ?   ?   ?   B . n 
B 1 4   SER 4   -78 ?   ?   ?   B . n 
B 1 5   LYS 5   -77 ?   ?   ?   B . n 
B 1 6   HIS 6   -76 ?   ?   ?   B . n 
B 1 7   THR 7   -75 ?   ?   ?   B . n 
B 1 8   ILE 8   -74 ?   ?   ?   B . n 
B 1 9   GLN 9   -73 ?   ?   ?   B . n 
B 1 10  PRO 10  -72 ?   ?   ?   B . n 
B 1 11  VAL 11  -71 ?   ?   ?   B . n 
B 1 12  THR 12  -70 ?   ?   ?   B . n 
B 1 13  THR 13  -69 ?   ?   ?   B . n 
B 1 14  ALA 14  -68 ?   ?   ?   B . n 
B 1 15  GLN 15  -67 ?   ?   ?   B . n 
B 1 16  GLN 16  -66 ?   ?   ?   B . n 
B 1 17  THR 17  -65 ?   ?   ?   B . n 
B 1 18  TYR 18  -64 ?   ?   ?   B . n 
B 1 19  SER 19  -63 ?   ?   ?   B . n 
B 1 20  THR 20  -62 ?   ?   ?   B . n 
B 1 21  ALA 21  -61 ?   ?   ?   B . n 
B 1 22  GLU 22  -60 ?   ?   ?   B . n 
B 1 23  VAL 23  -59 ?   ?   ?   B . n 
B 1 24  ALA 24  -58 ?   ?   ?   B . n 
B 1 25  ARG 25  -57 ?   ?   ?   B . n 
B 1 26  MET 26  -56 ?   ?   ?   B . n 
B 1 27  TRP 27  -55 ?   ?   ?   B . n 
B 1 28  ALA 28  -54 ?   ?   ?   B . n 
B 1 29  VAL 29  -53 ?   ?   ?   B . n 
B 1 30  SER 30  -52 ?   ?   ?   B . n 
B 1 31  GLU 31  -51 ?   ?   ?   B . n 
B 1 32  SER 32  -50 ?   ?   ?   B . n 
B 1 33  SER 33  -49 ?   ?   ?   B . n 
B 1 34  VAL 34  -48 ?   ?   ?   B . n 
B 1 35  LYS 35  -47 ?   ?   ?   B . n 
B 1 36  ARG 36  -46 ?   ?   ?   B . n 
B 1 37  TRP 37  -45 ?   ?   ?   B . n 
B 1 38  SER 38  -44 ?   ?   ?   B . n 
B 1 39  ASP 39  -43 ?   ?   ?   B . n 
B 1 40  SER 40  -42 ?   ?   ?   B . n 
B 1 41  GLY 41  -41 ?   ?   ?   B . n 
B 1 42  ALA 42  -40 ?   ?   ?   B . n 
B 1 43  LEU 43  -39 ?   ?   ?   B . n 
B 1 44  SER 44  -38 ?   ?   ?   B . n 
B 1 45  CYS 45  -37 ?   ?   ?   B . n 
B 1 46  ILE 46  -36 ?   ?   ?   B . n 
B 1 47  ARG 47  -35 ?   ?   ?   B . n 
B 1 48  THR 48  -34 ?   ?   ?   B . n 
B 1 49  PRO 49  -33 ?   ?   ?   B . n 
B 1 50  GLY 50  -32 ?   ?   ?   B . n 
B 1 51  GLY 51  -31 ?   ?   ?   B . n 
B 1 52  HIS 52  -30 ?   ?   ?   B . n 
B 1 53  ARG 53  -29 ?   ?   ?   B . n 
B 1 54  ARG 54  -28 ?   ?   ?   B . n 
B 1 55  PHE 55  -27 ?   ?   ?   B . n 
B 1 56  THR 56  -26 ?   ?   ?   B . n 
B 1 57  LEU 57  -25 ?   ?   ?   B . n 
B 1 58  GLN 58  -24 ?   ?   ?   B . n 
B 1 59  ALA 59  -23 ?   ?   ?   B . n 
B 1 60  LEU 60  -22 ?   ?   ?   B . n 
B 1 61  LEU 61  -21 ?   ?   ?   B . n 
B 1 62  ASP 62  -20 ?   ?   ?   B . n 
B 1 63  PHE 63  -19 ?   ?   ?   B . n 
B 1 64  GLN 64  -18 ?   ?   ?   B . n 
B 1 65  ARG 65  -17 ?   ?   ?   B . n 
B 1 66  ALA 66  -16 ?   ?   ?   B . n 
B 1 67  GLY 67  -15 ?   ?   ?   B . n 
B 1 68  GLY 68  -14 ?   ?   ?   B . n 
B 1 69  VAL 69  -13 ?   ?   ?   B . n 
B 1 70  LEU 70  -12 ?   ?   ?   B . n 
B 1 71  ARG 71  -11 ?   ?   ?   B . n 
B 1 72  HIS 72  -10 ?   ?   ?   B . n 
B 1 73  GLY 73  -9  ?   ?   ?   B . n 
B 1 74  GLY 74  -8  ?   ?   ?   B . n 
B 1 75  GLN 75  -7  ?   ?   ?   B . n 
B 1 76  PRO 76  -6  ?   ?   ?   B . n 
B 1 77  GLY 77  -5  ?   ?   ?   B . n 
B 1 78  SER 78  -4  ?   ?   ?   B . n 
B 1 79  GLY 79  -3  ?   ?   ?   B . n 
B 1 80  ALA 80  -2  ?   ?   ?   B . n 
B 1 81  VAL 81  -1  ?   ?   ?   B . n 
B 1 82  SER 82  0   ?   ?   ?   B . n 
B 1 83  VAL 83  1   ?   ?   ?   B . n 
B 1 84  VAL 84  2   ?   ?   ?   B . n 
B 1 85  SER 85  3   ?   ?   ?   B . n 
B 1 86  ASP 86  4   ?   ?   ?   B . n 
B 1 87  GLY 87  5   ?   ?   ?   B . n 
B 1 88  ALA 88  6   ?   ?   ?   B . n 
B 1 89  ALA 89  7   ?   ?   ?   B . n 
B 1 90  ALA 90  8   ?   ?   ?   B . n 
B 1 91  VAL 91  9   ?   ?   ?   B . n 
B 1 92  THR 92  10  ?   ?   ?   B . n 
B 1 93  ALA 93  11  ?   ?   ?   B . n 
B 1 94  SER 94  12  ?   ?   ?   B . n 
B 1 95  LEU 95  13  13  LEU LEU B . n 
B 1 96  ASP 96  14  14  ASP ASP B . n 
B 1 97  GLN 97  15  15  GLN GLN B . n 
B 1 98  ALA 98  16  16  ALA ALA B . n 
B 1 99  LEU 99  17  17  LEU LEU B . n 
B 1 100 VAL 100 18  18  VAL VAL B . n 
B 1 101 ALA 101 19  19  ALA ALA B . n 
B 1 102 ARG 102 20  20  ARG ARG B . n 
B 1 103 ASP 103 21  21  ASP ASP B . n 
B 1 104 TRP 104 22  22  TRP TRP B . n 
B 1 105 ALA 105 23  23  ALA ALA B . n 
B 1 106 ALA 106 24  24  ALA ALA B . n 
B 1 107 LEU 107 25  25  LEU LEU B . n 
B 1 108 GLN 108 26  26  GLN GLN B . n 
B 1 109 ALA 109 27  27  ALA ALA B . n 
B 1 110 ARG 110 28  28  ARG ARG B . n 
B 1 111 TYR 111 29  29  TYR TYR B . n 
B 1 112 TYR 112 30  30  TYR TYR B . n 
B 1 113 GLU 113 31  31  GLU GLU B . n 
B 1 114 ALA 114 32  32  ALA ALA B . n 
B 1 115 ALA 115 33  33  ALA ALA B . n 
B 1 116 VAL 116 34  34  VAL VAL B . n 
B 1 117 ALA 117 35  35  ALA ALA B . n 
B 1 118 GLY 118 36  36  GLY GLY B . n 
B 1 119 ASP 119 37  37  ASP ASP B . n 
B 1 120 GLU 120 38  38  GLU GLU B . n 
B 1 121 LEU 121 39  39  LEU LEU B . n 
B 1 122 ALA 122 40  40  ALA ALA B . n 
B 1 123 GLY 123 41  41  GLY GLY B . n 
B 1 124 VAL 124 42  42  VAL VAL B . n 
B 1 125 ALA 125 43  43  ALA ALA B . n 
B 1 126 LEU 126 44  44  LEU LEU B . n 
B 1 127 LEU 127 45  45  LEU LEU B . n 
B 1 128 GLU 128 46  46  GLU GLU B . n 
B 1 129 ARG 129 47  47  ARG ARG B . n 
B 1 130 ALA 130 48  48  ALA ALA B . n 
B 1 131 TYR 131 49  49  TYR TYR B . n 
B 1 132 ARG 132 50  50  ARG ARG B . n 
B 1 133 SER 133 51  51  SER SER B . n 
B 1 134 GLY 134 52  52  GLY GLY B . n 
B 1 135 ILE 135 53  53  ILE ILE B . n 
B 1 136 PRO 136 54  54  PRO PRO B . n 
B 1 137 VAL 137 55  55  VAL VAL B . n 
B 1 138 VAL 138 56  56  VAL VAL B . n 
B 1 139 ALA 139 57  57  ALA ALA B . n 
B 1 140 LEU 140 58  58  LEU LEU B . n 
B 1 141 LYS 141 59  59  LYS LYS B . n 
B 1 142 GLU 142 60  60  GLU GLU B . n 
B 1 143 HIS 143 61  61  HIS HIS B . n 
B 1 144 VAL 144 62  62  VAL VAL B . n 
B 1 145 LEU 145 63  63  LEU LEU B . n 
B 1 146 THR 146 64  64  THR THR B . n 
B 1 147 PRO 147 65  65  PRO PRO B . n 
B 1 148 VAL 148 66  66  VAL VAL B . n 
B 1 149 LEU 149 67  67  LEU LEU B . n 
B 1 150 HIS 150 68  68  HIS HIS B . n 
B 1 151 LEU 151 69  69  LEU LEU B . n 
B 1 152 ILE 152 70  70  ILE ILE B . n 
B 1 153 GLY 153 71  71  GLY GLY B . n 
B 1 154 GLU 154 72  72  GLU GLU B . n 
B 1 155 ARG 155 73  73  ARG ARG B . n 
B 1 156 TRP 156 74  74  TRP TRP B . n 
B 1 157 ARG 157 75  75  ARG ARG B . n 
B 1 158 ARG 158 76  76  ARG ARG B . n 
B 1 159 GLY 159 77  77  GLY GLY B . n 
B 1 160 GLU 160 78  78  GLU GLU B . n 
B 1 161 LEU 161 79  79  LEU LEU B . n 
B 1 162 ASN 162 80  80  ASN ASN B . n 
B 1 163 ILE 163 81  81  ILE ILE B . n 
B 1 164 TRP 164 82  82  TRP TRP B . n 
B 1 165 GLU 165 83  83  GLU GLU B . n 
B 1 166 GLU 166 84  84  GLU GLU B . n 
B 1 167 HIS 167 85  85  HIS HIS B . n 
B 1 168 LEU 168 86  86  LEU LEU B . n 
B 1 169 ALA 169 87  87  ALA ALA B . n 
B 1 170 SER 170 88  88  SER SER B . n 
B 1 171 GLN 171 89  89  GLN GLN B . n 
B 1 172 VAL 172 90  90  VAL VAL B . n 
B 1 173 THR 173 91  91  THR THR B . n 
B 1 174 LEU 174 92  92  LEU LEU B . n 
B 1 175 ALA 175 93  93  ALA ALA B . n 
B 1 176 ALA 176 94  94  ALA ALA B . n 
B 1 177 THR 177 95  95  THR THR B . n 
B 1 178 GLU 178 96  96  GLU GLU B . n 
B 1 179 HIS 179 97  97  HIS HIS B . n 
B 1 180 LEU 180 98  98  LEU LEU B . n 
B 1 181 HIS 181 99  99  HIS HIS B . n 
B 1 182 ARG 182 100 100 ARG ARG B . n 
B 1 183 GLN 183 101 101 GLN GLN B . n 
B 1 184 LEU 184 102 102 LEU LEU B . n 
B 1 185 PRO 185 103 103 PRO PRO B . n 
B 1 186 ARG 186 104 104 ARG ARG B . n 
B 1 187 ALA 187 105 105 ALA ALA B . n 
B 1 188 PRO 188 106 106 PRO PRO B . n 
B 1 189 PHE 189 107 107 PHE PHE B . n 
B 1 190 ASN 190 108 108 ASN ASN B . n 
B 1 191 GLY 191 109 109 GLY GLY B . n 
B 1 192 ARG 192 110 110 ARG ARG B . n 
B 1 193 LEU 193 111 111 LEU LEU B . n 
B 1 194 ALA 194 112 112 ALA ALA B . n 
B 1 195 LEU 195 113 113 LEU LEU B . n 
B 1 196 CYS 196 114 114 CYS CYS B . n 
B 1 197 GLY 197 115 115 GLY GLY B . n 
B 1 198 CYS 198 116 116 CYS CYS B . n 
B 1 199 PRO 199 117 117 PRO PRO B . n 
B 1 200 GLU 200 118 118 GLU GLU B . n 
B 1 201 GLY 201 119 119 GLY GLY B . n 
B 1 202 ASP 202 120 120 ASP ASP B . n 
B 1 203 LEU 203 121 121 LEU LEU B . n 
B 1 204 HIS 204 122 122 HIS HIS B . n 
B 1 205 GLU 205 123 123 GLU GLU B . n 
B 1 206 ILE 206 124 124 ILE ILE B . n 
B 1 207 ALA 207 125 125 ALA ALA B . n 
B 1 208 LEU 208 126 126 LEU LEU B . n 
B 1 209 HIS 209 127 127 HIS HIS B . n 
B 1 210 LEU 210 128 128 LEU LEU B . n 
B 1 211 VAL 211 129 129 VAL VAL B . n 
B 1 212 MET 212 130 130 MET MET B . n 
B 1 213 GLU 213 131 131 GLU GLU B . n 
B 1 214 VAL 214 132 132 VAL VAL B . n 
B 1 215 LEU 215 133 133 LEU LEU B . n 
B 1 216 GLU 216 134 134 GLU GLU B . n 
B 1 217 VAL 217 135 135 VAL VAL B . n 
B 1 218 GLU 218 136 136 GLU GLU B . n 
B 1 219 GLY 219 137 137 GLY GLY B . n 
B 1 220 TRP 220 138 138 TRP TRP B . n 
B 1 221 ARG 221 139 139 ARG ARG B . n 
B 1 222 VAL 222 140 140 VAL VAL B . n 
B 1 223 LEU 223 141 141 LEU LEU B . n 
B 1 224 SER 224 142 142 SER SER B . n 
B 1 225 LEU 225 143 143 LEU LEU B . n 
B 1 226 GLY 226 144 144 GLY GLY B . n 
B 1 227 PRO 227 145 145 PRO PRO B . n 
B 1 228 ASN 228 146 146 ASN ASN B . n 
B 1 229 THR 229 147 147 THR THR B . n 
B 1 230 PRO 230 148 148 PRO PRO B . n 
B 1 231 LEU 231 149 149 LEU LEU B . n 
B 1 232 PHE 232 150 150 PHE PHE B . n 
B 1 233 SER 233 151 151 SER SER B . n 
B 1 234 PHE 234 152 152 PHE PHE B . n 
B 1 235 ALA 235 153 153 ALA ALA B . n 
B 1 236 ASP 236 154 154 ASP ASP B . n 
B 1 237 ALA 237 155 155 ALA ALA B . n 
B 1 238 VAL 238 156 156 VAL VAL B . n 
B 1 239 ARG 239 157 157 ARG ARG B . n 
B 1 240 ARG 240 158 158 ARG ARG B . n 
B 1 241 PHE 241 159 159 PHE PHE B . n 
B 1 242 SER 242 160 160 SER SER B . n 
B 1 243 PRO 243 161 161 PRO PRO B . n 
B 1 244 GLN 244 162 162 GLN GLN B . n 
B 1 245 LEU 245 163 163 LEU LEU B . n 
B 1 246 VAL 246 164 164 VAL VAL B . n 
B 1 247 CYS 247 165 165 CYS CYS B . n 
B 1 248 ILE 248 166 166 ILE ILE B . n 
B 1 249 SER 249 167 167 SER SER B . n 
B 1 250 ALA 250 168 168 ALA ALA B . n 
B 1 251 THR 251 169 169 THR THR B . n 
B 1 252 ILE 252 170 170 ILE ILE B . n 
B 1 253 VAL 253 171 171 VAL VAL B . n 
B 1 254 HIS 254 172 172 HIS HIS B . n 
B 1 255 ASP 255 173 173 ASP ASP B . n 
B 1 256 LEU 256 174 174 LEU LEU B . n 
B 1 257 GLU 257 175 175 GLU GLU B . n 
B 1 258 ARG 258 176 176 ARG ARG B . n 
B 1 259 LEU 259 177 177 LEU LEU B . n 
B 1 260 ARG 260 178 178 ARG ARG B . n 
B 1 261 ARG 261 179 179 ARG ARG B . n 
B 1 262 ASP 262 180 180 ASP ASP B . n 
B 1 263 TYR 263 181 181 TYR TYR B . n 
B 1 264 GLY 264 182 182 GLY GLY B . n 
B 1 265 ASP 265 183 183 ASP ASP B . n 
B 1 266 PHE 266 184 184 PHE PHE B . n 
B 1 267 TYR 267 185 185 TYR TYR B . n 
B 1 268 HIS 268 186 186 HIS HIS B . n 
B 1 269 THR 269 187 187 THR THR B . n 
B 1 270 VAL 270 188 188 VAL VAL B . n 
B 1 271 ARG 271 189 189 ARG ARG B . n 
B 1 272 GLN 272 190 190 GLN GLN B . n 
B 1 273 HIS 273 191 191 HIS HIS B . n 
B 1 274 GLY 274 192 192 GLY GLY B . n 
B 1 275 ALA 275 193 193 ALA ALA B . n 
B 1 276 ARG 276 194 194 ARG ARG B . n 
B 1 277 ILE 277 195 195 ILE ILE B . n 
B 1 278 VAL 278 196 196 VAL VAL B . n 
B 1 279 ILE 279 197 197 ILE ILE B . n 
B 1 280 GLY 280 198 198 GLY GLY B . n 
B 1 281 GLY 281 199 199 GLY GLY B . n 
B 1 282 ALA 282 200 200 ALA ALA B . n 
B 1 283 ALA 283 201 201 ALA ALA B . n 
B 1 284 PHE 284 202 202 PHE PHE B . n 
B 1 285 ALA 285 203 203 ALA ALA B . n 
B 1 286 ASP 286 204 204 ASP ASP B . n 
B 1 287 PRO 287 205 205 PRO PRO B . n 
B 1 288 GLN 288 206 206 GLN GLN B . n 
B 1 289 VAL 289 207 207 VAL VAL B . n 
B 1 290 ARG 290 208 208 ARG ARG B . n 
B 1 291 GLU 291 209 209 GLU GLU B . n 
B 1 292 ILE 292 210 210 ILE ILE B . n 
B 1 293 PHE 293 211 211 PHE PHE B . n 
B 1 294 ILE 294 212 212 ILE ILE B . n 
B 1 295 HIS 295 213 213 HIS HIS B . n 
B 1 296 ASP 296 214 214 ASP ASP B . n 
B 1 297 TYR 297 215 215 TYR TYR B . n 
B 1 298 GLN 298 216 216 GLN GLN B . n 
B 1 299 ALA 299 217 217 ALA ALA B . n 
B 1 300 ALA 300 218 218 ALA ALA B . n 
B 1 301 GLY 301 219 219 GLY GLY B . n 
B 1 302 LEU 302 220 220 LEU LEU B . n 
B 1 303 THR 303 221 221 THR THR B . n 
B 1 304 ASP 304 222 222 ASP ASP B . n 
B 1 305 PHE 305 223 223 PHE PHE B . n 
B 1 306 LEU 306 224 224 LEU LEU B . n 
B 1 307 ASP 307 225 225 ASP ASP B . n 
B 1 308 TYR 308 226 226 TYR TYR B . n 
B 1 309 LEU 309 227 227 LEU LEU B . n 
B 1 310 ARG 310 228 228 ARG ARG B . n 
B 1 311 ARG 311 229 229 ARG ARG B . n 
B 1 312 GLU 312 230 230 GLU GLU B . n 
B 1 313 PHE 313 231 231 PHE PHE B . n 
B 1 314 PRO 314 232 232 PRO PRO B . n 
B 1 315 THR 315 233 233 THR THR B . n 
B 1 316 PRO 316 234 234 PRO PRO B . n 
B 1 317 ALA 317 235 ?   ?   ?   B . n 
B 1 318 VAL 318 236 ?   ?   ?   B . n 
B 1 319 ALA 319 237 ?   ?   ?   B . n 
B 1 320 THR 320 238 ?   ?   ?   B . n 
B 1 321 GLY 321 239 ?   ?   ?   B . n 
B 1 322 HIS 322 240 ?   ?   ?   B . n 
B 1 323 HIS 323 241 ?   ?   ?   B . n 
B 1 324 HIS 324 242 ?   ?   ?   B . n 
B 1 325 HIS 325 243 ?   ?   ?   B . n 
B 1 326 HIS 326 244 ?   ?   ?   B . n 
B 1 327 HIS 327 245 ?   ?   ?   B . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 5AD ? ? 5AD ? ? 'SUBJECT OF INVESTIGATION' ? 
2 B12 ? ? B12 ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 B12 1  301 301 B12 B12 A . 
D 3 5AD 1  302 302 5AD 5AD A . 
E 2 B12 1  301 301 B12 B12 B . 
F 3 5AD 1  302 302 5AD 5AD B . 
G 4 HOH 1  401 35  HOH HOH A . 
G 4 HOH 2  402 14  HOH HOH A . 
G 4 HOH 3  403 49  HOH HOH A . 
G 4 HOH 4  404 11  HOH HOH A . 
G 4 HOH 5  405 2   HOH HOH A . 
G 4 HOH 6  406 10  HOH HOH A . 
G 4 HOH 7  407 50  HOH HOH A . 
G 4 HOH 8  408 3   HOH HOH A . 
G 4 HOH 9  409 34  HOH HOH A . 
G 4 HOH 10 410 6   HOH HOH A . 
G 4 HOH 11 411 9   HOH HOH A . 
G 4 HOH 12 412 48  HOH HOH A . 
G 4 HOH 13 413 4   HOH HOH A . 
G 4 HOH 14 414 22  HOH HOH A . 
G 4 HOH 15 415 26  HOH HOH A . 
G 4 HOH 16 416 18  HOH HOH A . 
G 4 HOH 17 417 27  HOH HOH A . 
G 4 HOH 18 418 25  HOH HOH A . 
G 4 HOH 19 419 16  HOH HOH A . 
G 4 HOH 20 420 28  HOH HOH A . 
G 4 HOH 21 421 24  HOH HOH A . 
H 4 HOH 1  401 12  HOH HOH B . 
H 4 HOH 2  402 51  HOH HOH B . 
H 4 HOH 3  403 43  HOH HOH B . 
H 4 HOH 4  404 15  HOH HOH B . 
H 4 HOH 5  405 52  HOH HOH B . 
H 4 HOH 6  406 20  HOH HOH B . 
H 4 HOH 7  407 33  HOH HOH B . 
H 4 HOH 8  408 53  HOH HOH B . 
H 4 HOH 9  409 37  HOH HOH B . 
H 4 HOH 10 410 17  HOH HOH B . 
H 4 HOH 11 411 31  HOH HOH B . 
H 4 HOH 12 412 38  HOH HOH B . 
H 4 HOH 13 413 23  HOH HOH B . 
H 4 HOH 14 414 5   HOH HOH B . 
H 4 HOH 15 415 13  HOH HOH B . 
H 4 HOH 16 416 42  HOH HOH B . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC ? ? ? 5.8.0419 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? DIALS  ? ? ? .        2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XSCALE ? ? ? .        3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .        4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8JBS 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     125.218 
_cell.length_a_esd                 ? 
_cell.length_b                     125.218 
_cell.length_b_esd                 ? 
_cell.length_c                     73.088 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        12 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8JBS 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                152 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 31 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8JBS 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.29 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          46.27 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              8.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
;0.1M Amino acids, 0.1 M Buffer System 3 (Bicine and Tris) pH 8.5, 50% v/v Precipitant Mix 3 (Glycerol and Poly(ethylene glycol) 4000)
;
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            277 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 XE 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2021-11-25 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.9762 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'DIAMOND BEAMLINE I03' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.9762 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   I03 
_diffrn_source.pdbx_synchrotron_site       Diamond 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8JBS 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.30 
_reflns.d_resolution_low                               108.442 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     29650 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                20.6 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          12.5 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.163 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   1.0 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.30 
_reflns_shell.d_res_low                                     2.34 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           0.62 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2912 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               19.5 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.538 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          98.91 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  2.659 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            -2.25 
_refine.aniso_B[1][2]                            -1.12 
_refine.aniso_B[1][3]                            -0.00 
_refine.aniso_B[2][2]                            -2.25 
_refine.aniso_B[2][3]                            -0.00 
_refine.aniso_B[3][3]                            7.29 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               59.044 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.968 
_refine.correlation_coeff_Fo_to_Fc_free          0.946 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8JBS 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.30 
_refine.ls_d_res_low                             108.44 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     28126 
_refine.ls_number_reflns_R_free                  1503 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.92 
_refine.ls_percent_reflns_R_free                 5.1 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.18791 
_refine.ls_R_factor_R_free                       0.23609 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.18531 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.237 
_refine.pdbx_overall_ESU_R_Free                  0.204 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             9.602 
_refine.overall_SU_ML                            0.209 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.30 
_refine_hist.d_res_low                        108.44 
_refine_hist.number_atoms_solvent             37 
_refine_hist.number_atoms_total               3825 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3788 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.008  0.012  3902 ? r_bond_refined_d             ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.015  3653 ? r_bond_other_d               ? ? 
'X-RAY DIFFRACTION' ? 2.021  1.905  5378 ? r_angle_refined_deg          ? ? 
'X-RAY DIFFRACTION' ? 0.609  1.805  8314 ? r_angle_other_deg            ? ? 
'X-RAY DIFFRACTION' ? 6.659  5.000  447  ? r_dihedral_angle_1_deg       ? ? 
'X-RAY DIFFRACTION' ? 9.541  5.000  42   ? r_dihedral_angle_2_deg       ? ? 
'X-RAY DIFFRACTION' ? 14.450 10.000 565  ? r_dihedral_angle_3_deg       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_dihedral_angle_4_deg       ? ? 
'X-RAY DIFFRACTION' ? 0.092  0.200  593  ? r_chiral_restr               ? ? 
'X-RAY DIFFRACTION' ? 0.007  0.020  4701 ? r_gen_planes_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.002  0.020  985  ? r_gen_planes_other           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbd_refined                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbd_other                  ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbtor_refined              ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbtor_other                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_xyhbond_nbd_refined        ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_xyhbond_nbd_other          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_metal_ion_refined          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_metal_ion_other            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_vdw_refined       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_vdw_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_hbond_refined     ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_hbond_other       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_metal_ion_refined ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_metal_ion_other   ? ? 
'X-RAY DIFFRACTION' ? 5.055  5.810  1794 ? r_mcbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 5.044  5.811  1794 ? r_mcbond_other               ? ? 
'X-RAY DIFFRACTION' ? 6.933  10.429 2239 ? r_mcangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 6.933  10.433 2240 ? r_mcangle_other              ? ? 
'X-RAY DIFFRACTION' ? 5.790  6.099  2108 ? r_scbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 5.789  6.098  2109 ? r_scbond_other               ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_scangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 8.293  10.974 3140 ? r_scangle_other              ? ? 
'X-RAY DIFFRACTION' ? 9.874  56.66  4317 ? r_long_range_B_refined       ? ? 
'X-RAY DIFFRACTION' ? 9.876  56.53  4315 ? r_long_range_B_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_rigid_bond_restr           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_sphericity_free            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_sphericity_bonded          ? ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       2.300 
_refine_ls_shell.d_res_low                        2.360 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             83 
_refine_ls_shell.number_reflns_R_work             2069 
_refine_ls_shell.percent_reflns_obs               98.90 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  0.362 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.366 
# 
_struct.entry_id                     8JBS 
_struct.title                        'B12-binding domain from Chloracidobacterium thermophilum MerR family protein, dark state' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8JBS 
_struct_keywords.text            'B12-dependent transcription regulators from the MerR superfamily, TRANSCRIPTION' 
_struct_keywords.pdbx_keywords   TRANSCRIPTION 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 2 ? 
F N N 3 ? 
G N N 4 ? 
H N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    PDB 
_struct_ref.db_code                    8JBS 
_struct_ref.pdbx_db_accession          8JBS 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   ? 
_struct_ref.pdbx_align_begin           1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8JBS A 1 ? 327 ? 8JBS -81 ? 245 ? -81 245 
2 1 8JBS B 1 ? 327 ? 8JBS -81 ? 245 ? -81 245 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_and_software_defined_assembly PISA dimeric   2 
2 software_defined_assembly            PISA monomeric 1 
3 software_defined_assembly            PISA monomeric 1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2990  ? 
1 MORE         -9    ? 
1 'SSA (A^2)'  20820 ? 
2 'ABSA (A^2)' 2480  ? 
2 MORE         -12   ? 
2 'SSA (A^2)'  11180 ? 
3 'ABSA (A^2)' 2480  ? 
3 MORE         -10   ? 
3 'SSA (A^2)'  10700 ? 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,B,C,D,E,F,G,H 
2 1 A,C,D,G         
3 1 B,E,F,H         
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ALA A 93  ? ARG A 102 ? ALA A 11  ARG A 20  1 ? 10 
HELX_P HELX_P2  AA2 ASP A 103 ? VAL A 116 ? ASP A 21  VAL A 34  1 ? 14 
HELX_P HELX_P3  AA3 ASP A 119 ? SER A 133 ? ASP A 37  SER A 51  1 ? 15 
HELX_P HELX_P4  AA4 PRO A 136 ? VAL A 144 ? PRO A 54  VAL A 62  1 ? 9  
HELX_P HELX_P5  AA5 VAL A 144 ? ARG A 158 ? VAL A 62  ARG A 76  1 ? 15 
HELX_P HELX_P6  AA6 ASN A 162 ? ARG A 182 ? ASN A 80  ARG A 100 1 ? 21 
HELX_P HELX_P7  AA7 GLU A 205 ? GLU A 218 ? GLU A 123 GLU A 136 1 ? 14 
HELX_P HELX_P8  AA8 PRO A 230 ? SER A 242 ? PRO A 148 SER A 160 1 ? 13 
HELX_P HELX_P9  AA9 ASP A 255 ? HIS A 273 ? ASP A 173 HIS A 191 1 ? 19 
HELX_P HELX_P10 AB1 GLY A 281 ? ALA A 285 ? GLY A 199 ALA A 203 5 ? 5  
HELX_P HELX_P11 AB2 ASP A 286 ? PHE A 293 ? ASP A 204 PHE A 211 1 ? 8  
HELX_P HELX_P12 AB3 GLY A 301 ? PHE A 313 ? GLY A 219 PHE A 231 1 ? 13 
HELX_P HELX_P13 AB4 ASP B 96  ? ARG B 102 ? ASP B 14  ARG B 20  1 ? 7  
HELX_P HELX_P14 AB5 ASP B 103 ? GLY B 118 ? ASP B 21  GLY B 36  1 ? 16 
HELX_P HELX_P15 AB6 ASP B 119 ? ARG B 132 ? ASP B 37  ARG B 50  1 ? 14 
HELX_P HELX_P16 AB7 PRO B 136 ? VAL B 144 ? PRO B 54  VAL B 62  1 ? 9  
HELX_P HELX_P17 AB8 VAL B 144 ? ARG B 158 ? VAL B 62  ARG B 76  1 ? 15 
HELX_P HELX_P18 AB9 ASN B 162 ? ARG B 182 ? ASN B 80  ARG B 100 1 ? 21 
HELX_P HELX_P19 AC1 GLU B 205 ? GLU B 218 ? GLU B 123 GLU B 136 1 ? 14 
HELX_P HELX_P20 AC2 PRO B 230 ? ARG B 240 ? PRO B 148 ARG B 158 1 ? 11 
HELX_P HELX_P21 AC3 ASP B 255 ? GLN B 272 ? ASP B 173 GLN B 190 1 ? 18 
HELX_P HELX_P22 AC4 ALA B 282 ? ALA B 285 ? ALA B 200 ALA B 203 5 ? 4  
HELX_P HELX_P23 AC5 ASP B 286 ? PHE B 293 ? ASP B 204 PHE B 211 1 ? 8  
HELX_P HELX_P24 AC6 LEU B 302 ? PHE B 313 ? LEU B 220 PHE B 231 1 ? 12 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1 metalc ? ? A HIS 204 NE2 ? ? ? 1_555 C B12 . CO ? ? A HIS 122 A B12 301 1_555 ? ? ? ? ? ? ? 2.334 ? ? 
metalc2 metalc ? ? B HIS 204 NE2 ? ? ? 1_555 E B12 . CO ? ? B HIS 122 B B12 301 1_555 ? ? ? ? ? ? ? 2.260 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  NE2 ? A HIS 204 ? A HIS 122 ? 1_555 CO ? C B12 . ? A B12 301 ? 1_555 N21 ? C B12 . ? A B12 301 ? 1_555 91.4  ? 
2  NE2 ? A HIS 204 ? A HIS 122 ? 1_555 CO ? C B12 . ? A B12 301 ? 1_555 N22 ? C B12 . ? A B12 301 ? 1_555 84.1  ? 
3  N21 ? C B12 .   ? A B12 301 ? 1_555 CO ? C B12 . ? A B12 301 ? 1_555 N22 ? C B12 . ? A B12 301 ? 1_555 89.4  ? 
4  NE2 ? A HIS 204 ? A HIS 122 ? 1_555 CO ? C B12 . ? A B12 301 ? 1_555 N23 ? C B12 . ? A B12 301 ? 1_555 81.8  ? 
5  N21 ? C B12 .   ? A B12 301 ? 1_555 CO ? C B12 . ? A B12 301 ? 1_555 N23 ? C B12 . ? A B12 301 ? 1_555 170.6 ? 
6  N22 ? C B12 .   ? A B12 301 ? 1_555 CO ? C B12 . ? A B12 301 ? 1_555 N23 ? C B12 . ? A B12 301 ? 1_555 96.4  ? 
7  NE2 ? A HIS 204 ? A HIS 122 ? 1_555 CO ? C B12 . ? A B12 301 ? 1_555 N24 ? C B12 . ? A B12 301 ? 1_555 100.3 ? 
8  N21 ? C B12 .   ? A B12 301 ? 1_555 CO ? C B12 . ? A B12 301 ? 1_555 N24 ? C B12 . ? A B12 301 ? 1_555 81.9  ? 
9  N22 ? C B12 .   ? A B12 301 ? 1_555 CO ? C B12 . ? A B12 301 ? 1_555 N24 ? C B12 . ? A B12 301 ? 1_555 170.3 ? 
10 N23 ? C B12 .   ? A B12 301 ? 1_555 CO ? C B12 . ? A B12 301 ? 1_555 N24 ? C B12 . ? A B12 301 ? 1_555 92.8  ? 
11 NE2 ? B HIS 204 ? B HIS 122 ? 1_555 CO ? E B12 . ? B B12 301 ? 1_555 N21 ? E B12 . ? B B12 301 ? 1_555 95.6  ? 
12 NE2 ? B HIS 204 ? B HIS 122 ? 1_555 CO ? E B12 . ? B B12 301 ? 1_555 N22 ? E B12 . ? B B12 301 ? 1_555 79.8  ? 
13 N21 ? E B12 .   ? B B12 301 ? 1_555 CO ? E B12 . ? B B12 301 ? 1_555 N22 ? E B12 . ? B B12 301 ? 1_555 88.9  ? 
14 NE2 ? B HIS 204 ? B HIS 122 ? 1_555 CO ? E B12 . ? B B12 301 ? 1_555 N23 ? E B12 . ? B B12 301 ? 1_555 78.1  ? 
15 N21 ? E B12 .   ? B B12 301 ? 1_555 CO ? E B12 . ? B B12 301 ? 1_555 N23 ? E B12 . ? B B12 301 ? 1_555 171.1 ? 
16 N22 ? E B12 .   ? B B12 301 ? 1_555 CO ? E B12 . ? B B12 301 ? 1_555 N23 ? E B12 . ? B B12 301 ? 1_555 96.0  ? 
17 NE2 ? B HIS 204 ? B HIS 122 ? 1_555 CO ? E B12 . ? B B12 301 ? 1_555 N24 ? E B12 . ? B B12 301 ? 1_555 104.8 ? 
18 N21 ? E B12 .   ? B B12 301 ? 1_555 CO ? E B12 . ? B B12 301 ? 1_555 N24 ? E B12 . ? B B12 301 ? 1_555 81.3  ? 
19 N22 ? E B12 .   ? B B12 301 ? 1_555 CO ? E B12 . ? B B12 301 ? 1_555 N24 ? E B12 . ? B B12 301 ? 1_555 169.5 ? 
20 N23 ? E B12 .   ? B B12 301 ? 1_555 CO ? E B12 . ? B B12 301 ? 1_555 N24 ? E B12 . ? B B12 301 ? 1_555 94.2  ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 5 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel 
AA1 2 3 ? parallel 
AA1 3 4 ? parallel 
AA1 4 5 ? parallel 
AA2 1 2 ? parallel 
AA2 2 3 ? parallel 
AA2 3 4 ? parallel 
AA2 4 5 ? parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ARG A 221 ? THR A 229 ? ARG A 139 THR A 147 
AA1 2 LEU A 193 ? PRO A 199 ? LEU A 111 PRO A 117 
AA1 3 LEU A 245 ? SER A 249 ? LEU A 163 SER A 167 
AA1 4 ARG A 276 ? GLY A 280 ? ARG A 194 GLY A 198 
AA1 5 TYR A 297 ? GLN A 298 ? TYR A 215 GLN A 216 
AA2 1 ARG B 221 ? GLY B 226 ? ARG B 139 GLY B 144 
AA2 2 LEU B 193 ? GLY B 197 ? LEU B 111 GLY B 115 
AA2 3 LEU B 245 ? SER B 249 ? LEU B 163 SER B 167 
AA2 4 ARG B 276 ? GLY B 280 ? ARG B 194 GLY B 198 
AA2 5 TYR B 297 ? ALA B 299 ? TYR B 215 ALA B 217 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O LEU A 225 ? O LEU A 143 N CYS A 196 ? N CYS A 114 
AA1 2 3 N LEU A 195 ? N LEU A 113 O LEU A 245 ? O LEU A 163 
AA1 3 4 N VAL A 246 ? N VAL A 164 O ARG A 276 ? O ARG A 194 
AA1 4 5 N ILE A 279 ? N ILE A 197 O TYR A 297 ? O TYR A 215 
AA2 1 2 O LEU B 225 ? O LEU B 143 N CYS B 196 ? N CYS B 114 
AA2 2 3 N LEU B 195 ? N LEU B 113 O CYS B 247 ? O CYS B 165 
AA2 3 4 N VAL B 246 ? N VAL B 164 O VAL B 278 ? O VAL B 196 
AA2 4 5 N ILE B 279 ? N ILE B 197 O ALA B 299 ? O ALA B 217 
# 
_pdbx_entry_details.entry_id                   8JBS 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             NE 
_pdbx_validate_rmsd_angle.auth_asym_id_1             A 
_pdbx_validate_rmsd_angle.auth_comp_id_1             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_1              179 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_2             CZ 
_pdbx_validate_rmsd_angle.auth_asym_id_2             A 
_pdbx_validate_rmsd_angle.auth_comp_id_2             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_2              179 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_3             NH2 
_pdbx_validate_rmsd_angle.auth_asym_id_3             A 
_pdbx_validate_rmsd_angle.auth_comp_id_3             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_3              179 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             ? 
_pdbx_validate_rmsd_angle.angle_value                117.25 
_pdbx_validate_rmsd_angle.angle_target_value         120.30 
_pdbx_validate_rmsd_angle.angle_deviation            -3.05 
_pdbx_validate_rmsd_angle.angle_standard_deviation   0.50 
_pdbx_validate_rmsd_angle.linker_flag                N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 THR A 10  ? ? -108.82 69.66  
2 1 ALA A 105 ? ? -48.20  151.41 
3 1 SER A 160 ? ? 37.34   69.09  
4 1 VAL B 62  ? ? -131.38 -55.34 
5 1 PHE B 159 ? ? 62.93   -37.78 
6 1 ASP B 173 ? ? -91.12  54.57  
# 
loop_
_pdbx_validate_chiral.id 
_pdbx_validate_chiral.PDB_model_num 
_pdbx_validate_chiral.auth_atom_id 
_pdbx_validate_chiral.label_alt_id 
_pdbx_validate_chiral.auth_asym_id 
_pdbx_validate_chiral.auth_comp_id 
_pdbx_validate_chiral.auth_seq_id 
_pdbx_validate_chiral.PDB_ins_code 
_pdbx_validate_chiral.details 
_pdbx_validate_chiral.omega 
1 1 C19 ? A B12 301 ? PLANAR . 
2 1 C19 ? B B12 301 ? PLANAR . 
# 
loop_
_pdbx_validate_planes.id 
_pdbx_validate_planes.PDB_model_num 
_pdbx_validate_planes.auth_comp_id 
_pdbx_validate_planes.auth_asym_id 
_pdbx_validate_planes.auth_seq_id 
_pdbx_validate_planes.PDB_ins_code 
_pdbx_validate_planes.label_alt_id 
_pdbx_validate_planes.rmsd 
_pdbx_validate_planes.type 
1 1 ARG A 110 ? ? 0.088 'SIDE CHAIN' 
2 1 ARG A 157 ? ? 0.085 'SIDE CHAIN' 
3 1 ARG A 194 ? ? 0.264 'SIDE CHAIN' 
4 1 ARG B 75  ? ? 0.079 'SIDE CHAIN' 
5 1 ARG B 110 ? ? 0.101 'SIDE CHAIN' 
6 1 ARG B 157 ? ? 0.146 'SIDE CHAIN' 
7 1 ARG B 158 ? ? 0.087 'SIDE CHAIN' 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A MET -81 ? A MET 1   
2   1 Y 1 A PRO -80 ? A PRO 2   
3   1 Y 1 A ARG -79 ? A ARG 3   
4   1 Y 1 A SER -78 ? A SER 4   
5   1 Y 1 A LYS -77 ? A LYS 5   
6   1 Y 1 A HIS -76 ? A HIS 6   
7   1 Y 1 A THR -75 ? A THR 7   
8   1 Y 1 A ILE -74 ? A ILE 8   
9   1 Y 1 A GLN -73 ? A GLN 9   
10  1 Y 1 A PRO -72 ? A PRO 10  
11  1 Y 1 A VAL -71 ? A VAL 11  
12  1 Y 1 A THR -70 ? A THR 12  
13  1 Y 1 A THR -69 ? A THR 13  
14  1 Y 1 A ALA -68 ? A ALA 14  
15  1 Y 1 A GLN -67 ? A GLN 15  
16  1 Y 1 A GLN -66 ? A GLN 16  
17  1 Y 1 A THR -65 ? A THR 17  
18  1 Y 1 A TYR -64 ? A TYR 18  
19  1 Y 1 A SER -63 ? A SER 19  
20  1 Y 1 A THR -62 ? A THR 20  
21  1 Y 1 A ALA -61 ? A ALA 21  
22  1 Y 1 A GLU -60 ? A GLU 22  
23  1 Y 1 A VAL -59 ? A VAL 23  
24  1 Y 1 A ALA -58 ? A ALA 24  
25  1 Y 1 A ARG -57 ? A ARG 25  
26  1 Y 1 A MET -56 ? A MET 26  
27  1 Y 1 A TRP -55 ? A TRP 27  
28  1 Y 1 A ALA -54 ? A ALA 28  
29  1 Y 1 A VAL -53 ? A VAL 29  
30  1 Y 1 A SER -52 ? A SER 30  
31  1 Y 1 A GLU -51 ? A GLU 31  
32  1 Y 1 A SER -50 ? A SER 32  
33  1 Y 1 A SER -49 ? A SER 33  
34  1 Y 1 A VAL -48 ? A VAL 34  
35  1 Y 1 A LYS -47 ? A LYS 35  
36  1 Y 1 A ARG -46 ? A ARG 36  
37  1 Y 1 A TRP -45 ? A TRP 37  
38  1 Y 1 A SER -44 ? A SER 38  
39  1 Y 1 A ASP -43 ? A ASP 39  
40  1 Y 1 A SER -42 ? A SER 40  
41  1 Y 1 A GLY -41 ? A GLY 41  
42  1 Y 1 A ALA -40 ? A ALA 42  
43  1 Y 1 A LEU -39 ? A LEU 43  
44  1 Y 1 A SER -38 ? A SER 44  
45  1 Y 1 A CYS -37 ? A CYS 45  
46  1 Y 1 A ILE -36 ? A ILE 46  
47  1 Y 1 A ARG -35 ? A ARG 47  
48  1 Y 1 A THR -34 ? A THR 48  
49  1 Y 1 A PRO -33 ? A PRO 49  
50  1 Y 1 A GLY -32 ? A GLY 50  
51  1 Y 1 A GLY -31 ? A GLY 51  
52  1 Y 1 A HIS -30 ? A HIS 52  
53  1 Y 1 A ARG -29 ? A ARG 53  
54  1 Y 1 A ARG -28 ? A ARG 54  
55  1 Y 1 A PHE -27 ? A PHE 55  
56  1 Y 1 A THR -26 ? A THR 56  
57  1 Y 1 A LEU -25 ? A LEU 57  
58  1 Y 1 A GLN -24 ? A GLN 58  
59  1 Y 1 A ALA -23 ? A ALA 59  
60  1 Y 1 A LEU -22 ? A LEU 60  
61  1 Y 1 A LEU -21 ? A LEU 61  
62  1 Y 1 A ASP -20 ? A ASP 62  
63  1 Y 1 A PHE -19 ? A PHE 63  
64  1 Y 1 A GLN -18 ? A GLN 64  
65  1 Y 1 A ARG -17 ? A ARG 65  
66  1 Y 1 A ALA -16 ? A ALA 66  
67  1 Y 1 A GLY -15 ? A GLY 67  
68  1 Y 1 A GLY -14 ? A GLY 68  
69  1 Y 1 A VAL -13 ? A VAL 69  
70  1 Y 1 A LEU -12 ? A LEU 70  
71  1 Y 1 A ARG -11 ? A ARG 71  
72  1 Y 1 A HIS -10 ? A HIS 72  
73  1 Y 1 A GLY -9  ? A GLY 73  
74  1 Y 1 A GLY -8  ? A GLY 74  
75  1 Y 1 A GLN -7  ? A GLN 75  
76  1 Y 1 A PRO -6  ? A PRO 76  
77  1 Y 1 A GLY -5  ? A GLY 77  
78  1 Y 1 A SER -4  ? A SER 78  
79  1 Y 1 A GLY -3  ? A GLY 79  
80  1 Y 1 A ALA -2  ? A ALA 80  
81  1 Y 1 A VAL -1  ? A VAL 81  
82  1 Y 1 A SER 0   ? A SER 82  
83  1 Y 1 A VAL 1   ? A VAL 83  
84  1 Y 1 A VAL 2   ? A VAL 84  
85  1 Y 1 A SER 3   ? A SER 85  
86  1 Y 1 A ASP 4   ? A ASP 86  
87  1 Y 1 A GLY 5   ? A GLY 87  
88  1 Y 1 A ALA 6   ? A ALA 88  
89  1 Y 1 A ALA 7   ? A ALA 89  
90  1 Y 1 A ALA 8   ? A ALA 90  
91  1 Y 1 A VAL 236 ? A VAL 318 
92  1 Y 1 A ALA 237 ? A ALA 319 
93  1 Y 1 A THR 238 ? A THR 320 
94  1 Y 1 A GLY 239 ? A GLY 321 
95  1 Y 1 A HIS 240 ? A HIS 322 
96  1 Y 1 A HIS 241 ? A HIS 323 
97  1 Y 1 A HIS 242 ? A HIS 324 
98  1 Y 1 A HIS 243 ? A HIS 325 
99  1 Y 1 A HIS 244 ? A HIS 326 
100 1 Y 1 A HIS 245 ? A HIS 327 
101 1 Y 1 B MET -81 ? B MET 1   
102 1 Y 1 B PRO -80 ? B PRO 2   
103 1 Y 1 B ARG -79 ? B ARG 3   
104 1 Y 1 B SER -78 ? B SER 4   
105 1 Y 1 B LYS -77 ? B LYS 5   
106 1 Y 1 B HIS -76 ? B HIS 6   
107 1 Y 1 B THR -75 ? B THR 7   
108 1 Y 1 B ILE -74 ? B ILE 8   
109 1 Y 1 B GLN -73 ? B GLN 9   
110 1 Y 1 B PRO -72 ? B PRO 10  
111 1 Y 1 B VAL -71 ? B VAL 11  
112 1 Y 1 B THR -70 ? B THR 12  
113 1 Y 1 B THR -69 ? B THR 13  
114 1 Y 1 B ALA -68 ? B ALA 14  
115 1 Y 1 B GLN -67 ? B GLN 15  
116 1 Y 1 B GLN -66 ? B GLN 16  
117 1 Y 1 B THR -65 ? B THR 17  
118 1 Y 1 B TYR -64 ? B TYR 18  
119 1 Y 1 B SER -63 ? B SER 19  
120 1 Y 1 B THR -62 ? B THR 20  
121 1 Y 1 B ALA -61 ? B ALA 21  
122 1 Y 1 B GLU -60 ? B GLU 22  
123 1 Y 1 B VAL -59 ? B VAL 23  
124 1 Y 1 B ALA -58 ? B ALA 24  
125 1 Y 1 B ARG -57 ? B ARG 25  
126 1 Y 1 B MET -56 ? B MET 26  
127 1 Y 1 B TRP -55 ? B TRP 27  
128 1 Y 1 B ALA -54 ? B ALA 28  
129 1 Y 1 B VAL -53 ? B VAL 29  
130 1 Y 1 B SER -52 ? B SER 30  
131 1 Y 1 B GLU -51 ? B GLU 31  
132 1 Y 1 B SER -50 ? B SER 32  
133 1 Y 1 B SER -49 ? B SER 33  
134 1 Y 1 B VAL -48 ? B VAL 34  
135 1 Y 1 B LYS -47 ? B LYS 35  
136 1 Y 1 B ARG -46 ? B ARG 36  
137 1 Y 1 B TRP -45 ? B TRP 37  
138 1 Y 1 B SER -44 ? B SER 38  
139 1 Y 1 B ASP -43 ? B ASP 39  
140 1 Y 1 B SER -42 ? B SER 40  
141 1 Y 1 B GLY -41 ? B GLY 41  
142 1 Y 1 B ALA -40 ? B ALA 42  
143 1 Y 1 B LEU -39 ? B LEU 43  
144 1 Y 1 B SER -38 ? B SER 44  
145 1 Y 1 B CYS -37 ? B CYS 45  
146 1 Y 1 B ILE -36 ? B ILE 46  
147 1 Y 1 B ARG -35 ? B ARG 47  
148 1 Y 1 B THR -34 ? B THR 48  
149 1 Y 1 B PRO -33 ? B PRO 49  
150 1 Y 1 B GLY -32 ? B GLY 50  
151 1 Y 1 B GLY -31 ? B GLY 51  
152 1 Y 1 B HIS -30 ? B HIS 52  
153 1 Y 1 B ARG -29 ? B ARG 53  
154 1 Y 1 B ARG -28 ? B ARG 54  
155 1 Y 1 B PHE -27 ? B PHE 55  
156 1 Y 1 B THR -26 ? B THR 56  
157 1 Y 1 B LEU -25 ? B LEU 57  
158 1 Y 1 B GLN -24 ? B GLN 58  
159 1 Y 1 B ALA -23 ? B ALA 59  
160 1 Y 1 B LEU -22 ? B LEU 60  
161 1 Y 1 B LEU -21 ? B LEU 61  
162 1 Y 1 B ASP -20 ? B ASP 62  
163 1 Y 1 B PHE -19 ? B PHE 63  
164 1 Y 1 B GLN -18 ? B GLN 64  
165 1 Y 1 B ARG -17 ? B ARG 65  
166 1 Y 1 B ALA -16 ? B ALA 66  
167 1 Y 1 B GLY -15 ? B GLY 67  
168 1 Y 1 B GLY -14 ? B GLY 68  
169 1 Y 1 B VAL -13 ? B VAL 69  
170 1 Y 1 B LEU -12 ? B LEU 70  
171 1 Y 1 B ARG -11 ? B ARG 71  
172 1 Y 1 B HIS -10 ? B HIS 72  
173 1 Y 1 B GLY -9  ? B GLY 73  
174 1 Y 1 B GLY -8  ? B GLY 74  
175 1 Y 1 B GLN -7  ? B GLN 75  
176 1 Y 1 B PRO -6  ? B PRO 76  
177 1 Y 1 B GLY -5  ? B GLY 77  
178 1 Y 1 B SER -4  ? B SER 78  
179 1 Y 1 B GLY -3  ? B GLY 79  
180 1 Y 1 B ALA -2  ? B ALA 80  
181 1 Y 1 B VAL -1  ? B VAL 81  
182 1 Y 1 B SER 0   ? B SER 82  
183 1 Y 1 B VAL 1   ? B VAL 83  
184 1 Y 1 B VAL 2   ? B VAL 84  
185 1 Y 1 B SER 3   ? B SER 85  
186 1 Y 1 B ASP 4   ? B ASP 86  
187 1 Y 1 B GLY 5   ? B GLY 87  
188 1 Y 1 B ALA 6   ? B ALA 88  
189 1 Y 1 B ALA 7   ? B ALA 89  
190 1 Y 1 B ALA 8   ? B ALA 90  
191 1 Y 1 B VAL 9   ? B VAL 91  
192 1 Y 1 B THR 10  ? B THR 92  
193 1 Y 1 B ALA 11  ? B ALA 93  
194 1 Y 1 B SER 12  ? B SER 94  
195 1 Y 1 B ALA 235 ? B ALA 317 
196 1 Y 1 B VAL 236 ? B VAL 318 
197 1 Y 1 B ALA 237 ? B ALA 319 
198 1 Y 1 B THR 238 ? B THR 320 
199 1 Y 1 B GLY 239 ? B GLY 321 
200 1 Y 1 B HIS 240 ? B HIS 322 
201 1 Y 1 B HIS 241 ? B HIS 323 
202 1 Y 1 B HIS 242 ? B HIS 324 
203 1 Y 1 B HIS 243 ? B HIS 325 
204 1 Y 1 B HIS 244 ? B HIS 326 
205 1 Y 1 B HIS 245 ? B HIS 327 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
5AD N1     N  Y N 1   
5AD C2     C  Y N 2   
5AD N3     N  Y N 3   
5AD C4     C  Y N 4   
5AD N9     N  Y N 5   
5AD C8     C  Y N 6   
5AD N7     N  Y N 7   
5AD C5     C  Y N 8   
5AD C6     C  Y N 9   
5AD N6     N  N N 10  
5AD "C1'"  C  N R 11  
5AD "C2'"  C  N R 12  
5AD "C3'"  C  N S 13  
5AD "C4'"  C  N R 14  
5AD "C5'"  C  N N 15  
5AD "O4'"  O  N N 16  
5AD "O2'"  O  N N 17  
5AD "O3'"  O  N N 18  
5AD H2     H  N N 19  
5AD H8     H  N N 20  
5AD HN61   H  N N 21  
5AD HN62   H  N N 22  
5AD "H1'"  H  N N 23  
5AD "H2'"  H  N N 24  
5AD "H3'"  H  N N 25  
5AD "H4'"  H  N N 26  
5AD "H5'1" H  N N 27  
5AD "H5'2" H  N N 28  
5AD "H5'3" H  N N 29  
5AD "HO2'" H  N N 30  
5AD "HO3'" H  N N 31  
ALA N      N  N N 32  
ALA CA     C  N S 33  
ALA C      C  N N 34  
ALA O      O  N N 35  
ALA CB     C  N N 36  
ALA OXT    O  N N 37  
ALA H      H  N N 38  
ALA H2     H  N N 39  
ALA HA     H  N N 40  
ALA HB1    H  N N 41  
ALA HB2    H  N N 42  
ALA HB3    H  N N 43  
ALA HXT    H  N N 44  
ARG N      N  N N 45  
ARG CA     C  N S 46  
ARG C      C  N N 47  
ARG O      O  N N 48  
ARG CB     C  N N 49  
ARG CG     C  N N 50  
ARG CD     C  N N 51  
ARG NE     N  N N 52  
ARG CZ     C  N N 53  
ARG NH1    N  N N 54  
ARG NH2    N  N N 55  
ARG OXT    O  N N 56  
ARG H      H  N N 57  
ARG H2     H  N N 58  
ARG HA     H  N N 59  
ARG HB2    H  N N 60  
ARG HB3    H  N N 61  
ARG HG2    H  N N 62  
ARG HG3    H  N N 63  
ARG HD2    H  N N 64  
ARG HD3    H  N N 65  
ARG HE     H  N N 66  
ARG HH11   H  N N 67  
ARG HH12   H  N N 68  
ARG HH21   H  N N 69  
ARG HH22   H  N N 70  
ARG HXT    H  N N 71  
ASN N      N  N N 72  
ASN CA     C  N S 73  
ASN C      C  N N 74  
ASN O      O  N N 75  
ASN CB     C  N N 76  
ASN CG     C  N N 77  
ASN OD1    O  N N 78  
ASN ND2    N  N N 79  
ASN OXT    O  N N 80  
ASN H      H  N N 81  
ASN H2     H  N N 82  
ASN HA     H  N N 83  
ASN HB2    H  N N 84  
ASN HB3    H  N N 85  
ASN HD21   H  N N 86  
ASN HD22   H  N N 87  
ASN HXT    H  N N 88  
ASP N      N  N N 89  
ASP CA     C  N S 90  
ASP C      C  N N 91  
ASP O      O  N N 92  
ASP CB     C  N N 93  
ASP CG     C  N N 94  
ASP OD1    O  N N 95  
ASP OD2    O  N N 96  
ASP OXT    O  N N 97  
ASP H      H  N N 98  
ASP H2     H  N N 99  
ASP HA     H  N N 100 
ASP HB2    H  N N 101 
ASP HB3    H  N N 102 
ASP HD2    H  N N 103 
ASP HXT    H  N N 104 
B12 CO     CO N N 105 
B12 N21    N  N N 106 
B12 N22    N  N N 107 
B12 N23    N  N N 108 
B12 N24    N  N N 109 
B12 C1     C  N R 110 
B12 C20    C  N N 111 
B12 C2     C  N S 112 
B12 C25    C  N N 113 
B12 C26    C  N N 114 
B12 C27    C  N N 115 
B12 O28    O  N N 116 
B12 N29    N  N N 117 
B12 C3     C  N S 118 
B12 C30    C  N N 119 
B12 C31    C  N N 120 
B12 C32    C  N N 121 
B12 O34    O  N N 122 
B12 N33    N  N N 123 
B12 C4     C  N N 124 
B12 C5     C  N N 125 
B12 C35    C  N N 126 
B12 C6     C  N N 127 
B12 C7     C  N S 128 
B12 C36    C  N N 129 
B12 C37    C  N N 130 
B12 C38    C  N N 131 
B12 O39    O  N N 132 
B12 N40    N  N N 133 
B12 C8     C  N S 134 
B12 C41    C  N N 135 
B12 C42    C  N N 136 
B12 C43    C  N N 137 
B12 O44    O  N N 138 
B12 N45    N  N N 139 
B12 C9     C  N N 140 
B12 C10    C  N N 141 
B12 C11    C  N N 142 
B12 C12    C  N N 143 
B12 C46    C  N N 144 
B12 C47    C  N N 145 
B12 C13    C  N S 146 
B12 C48    C  N N 147 
B12 C49    C  N N 148 
B12 C50    C  N N 149 
B12 O51    O  N N 150 
B12 N52    N  N N 151 
B12 C14    C  N N 152 
B12 C15    C  N N 153 
B12 C53    C  N N 154 
B12 C16    C  N N 155 
B12 C17    C  N R 156 
B12 C54    C  N N 157 
B12 C55    C  N N 158 
B12 C56    C  N N 159 
B12 C57    C  N N 160 
B12 O58    O  N N 161 
B12 N59    N  N N 162 
B12 C18    C  N R 163 
B12 C60    C  N N 164 
B12 C61    C  N N 165 
B12 O63    O  N N 166 
B12 N62    N  N N 167 
B12 C19    C  N R 168 
B12 C1P    C  N N 169 
B12 C2P    C  N R 170 
B12 C3P    C  N N 171 
B12 O3     O  N N 172 
B12 O4     O  N N 173 
B12 O5     O  N N 174 
B12 P      P  N N 175 
B12 O2     O  N N 176 
B12 C3R    C  N S 177 
B12 C2R    C  N R 178 
B12 O7R    O  N N 179 
B12 C1R    C  N S 180 
B12 O6R    O  N N 181 
B12 C4R    C  N R 182 
B12 C5R    C  N N 183 
B12 O8R    O  N N 184 
B12 N1B    N  Y N 185 
B12 C8B    C  Y N 186 
B12 C2B    C  Y N 187 
B12 N3B    N  Y N 188 
B12 C9B    C  Y N 189 
B12 C4B    C  Y N 190 
B12 C5B    C  Y N 191 
B12 C5M    C  N N 192 
B12 C6B    C  Y N 193 
B12 C6M    C  N N 194 
B12 C7B    C  Y N 195 
B12 H201   H  N N 196 
B12 H202   H  N N 197 
B12 H203   H  N N 198 
B12 H251   H  N N 199 
B12 H252   H  N N 200 
B12 H253   H  N N 201 
B12 H261   H  N N 202 
B12 H262   H  N N 203 
B12 H291   H  N N 204 
B12 H292   H  N N 205 
B12 H3     H  N N 206 
B12 H301   H  N N 207 
B12 H302   H  N N 208 
B12 H311   H  N N 209 
B12 H312   H  N N 210 
B12 H331   H  N N 211 
B12 H332   H  N N 212 
B12 H351   H  N N 213 
B12 H352   H  N N 214 
B12 H353   H  N N 215 
B12 H361   H  N N 216 
B12 H362   H  N N 217 
B12 H363   H  N N 218 
B12 H371   H  N N 219 
B12 H372   H  N N 220 
B12 H401   H  N N 221 
B12 H402   H  N N 222 
B12 H8     H  N N 223 
B12 H411   H  N N 224 
B12 H412   H  N N 225 
B12 H421   H  N N 226 
B12 H422   H  N N 227 
B12 H451   H  N N 228 
B12 H452   H  N N 229 
B12 H10    H  N N 230 
B12 H461   H  N N 231 
B12 H462   H  N N 232 
B12 H463   H  N N 233 
B12 H471   H  N N 234 
B12 H472   H  N N 235 
B12 H473   H  N N 236 
B12 H13    H  N N 237 
B12 H481   H  N N 238 
B12 H482   H  N N 239 
B12 H491   H  N N 240 
B12 H492   H  N N 241 
B12 H521   H  N N 242 
B12 H522   H  N N 243 
B12 H531   H  N N 244 
B12 H532   H  N N 245 
B12 H533   H  N N 246 
B12 H541   H  N N 247 
B12 H542   H  N N 248 
B12 H543   H  N N 249 
B12 H551   H  N N 250 
B12 H552   H  N N 251 
B12 H561   H  N N 252 
B12 H562   H  N N 253 
B12 H59    H  N N 254 
B12 H18    H  N N 255 
B12 H601   H  N N 256 
B12 H602   H  N N 257 
B12 H621   H  N N 258 
B12 H622   H  N N 259 
B12 H1P1   H  N N 260 
B12 H1P2   H  N N 261 
B12 H2P    H  N N 262 
B12 H3P1   H  N N 263 
B12 H3P2   H  N N 264 
B12 H3P3   H  N N 265 
B12 HOP5   H  N N 266 
B12 H3R    H  N N 267 
B12 H2R    H  N N 268 
B12 HOR7   H  N N 269 
B12 H1R    H  N N 270 
B12 H4R    H  N N 271 
B12 H5R1   H  N N 272 
B12 H5R2   H  N N 273 
B12 HOR8   H  N N 274 
B12 H2B    H  N N 275 
B12 H4B    H  N N 276 
B12 HM51   H  N N 277 
B12 HM52   H  N N 278 
B12 HM53   H  N N 279 
B12 HM61   H  N N 280 
B12 HM62   H  N N 281 
B12 HM63   H  N N 282 
B12 H7B    H  N N 283 
B12 H91    H  N N 284 
CYS N      N  N N 285 
CYS CA     C  N R 286 
CYS C      C  N N 287 
CYS O      O  N N 288 
CYS CB     C  N N 289 
CYS SG     S  N N 290 
CYS OXT    O  N N 291 
CYS H      H  N N 292 
CYS H2     H  N N 293 
CYS HA     H  N N 294 
CYS HB2    H  N N 295 
CYS HB3    H  N N 296 
CYS HG     H  N N 297 
CYS HXT    H  N N 298 
GLN N      N  N N 299 
GLN CA     C  N S 300 
GLN C      C  N N 301 
GLN O      O  N N 302 
GLN CB     C  N N 303 
GLN CG     C  N N 304 
GLN CD     C  N N 305 
GLN OE1    O  N N 306 
GLN NE2    N  N N 307 
GLN OXT    O  N N 308 
GLN H      H  N N 309 
GLN H2     H  N N 310 
GLN HA     H  N N 311 
GLN HB2    H  N N 312 
GLN HB3    H  N N 313 
GLN HG2    H  N N 314 
GLN HG3    H  N N 315 
GLN HE21   H  N N 316 
GLN HE22   H  N N 317 
GLN HXT    H  N N 318 
GLU N      N  N N 319 
GLU CA     C  N S 320 
GLU C      C  N N 321 
GLU O      O  N N 322 
GLU CB     C  N N 323 
GLU CG     C  N N 324 
GLU CD     C  N N 325 
GLU OE1    O  N N 326 
GLU OE2    O  N N 327 
GLU OXT    O  N N 328 
GLU H      H  N N 329 
GLU H2     H  N N 330 
GLU HA     H  N N 331 
GLU HB2    H  N N 332 
GLU HB3    H  N N 333 
GLU HG2    H  N N 334 
GLU HG3    H  N N 335 
GLU HE2    H  N N 336 
GLU HXT    H  N N 337 
GLY N      N  N N 338 
GLY CA     C  N N 339 
GLY C      C  N N 340 
GLY O      O  N N 341 
GLY OXT    O  N N 342 
GLY H      H  N N 343 
GLY H2     H  N N 344 
GLY HA2    H  N N 345 
GLY HA3    H  N N 346 
GLY HXT    H  N N 347 
HIS N      N  N N 348 
HIS CA     C  N S 349 
HIS C      C  N N 350 
HIS O      O  N N 351 
HIS CB     C  N N 352 
HIS CG     C  Y N 353 
HIS ND1    N  Y N 354 
HIS CD2    C  Y N 355 
HIS CE1    C  Y N 356 
HIS NE2    N  Y N 357 
HIS OXT    O  N N 358 
HIS H      H  N N 359 
HIS H2     H  N N 360 
HIS HA     H  N N 361 
HIS HB2    H  N N 362 
HIS HB3    H  N N 363 
HIS HD1    H  N N 364 
HIS HD2    H  N N 365 
HIS HE1    H  N N 366 
HIS HE2    H  N N 367 
HIS HXT    H  N N 368 
HOH O      O  N N 369 
HOH H1     H  N N 370 
HOH H2     H  N N 371 
ILE N      N  N N 372 
ILE CA     C  N S 373 
ILE C      C  N N 374 
ILE O      O  N N 375 
ILE CB     C  N S 376 
ILE CG1    C  N N 377 
ILE CG2    C  N N 378 
ILE CD1    C  N N 379 
ILE OXT    O  N N 380 
ILE H      H  N N 381 
ILE H2     H  N N 382 
ILE HA     H  N N 383 
ILE HB     H  N N 384 
ILE HG12   H  N N 385 
ILE HG13   H  N N 386 
ILE HG21   H  N N 387 
ILE HG22   H  N N 388 
ILE HG23   H  N N 389 
ILE HD11   H  N N 390 
ILE HD12   H  N N 391 
ILE HD13   H  N N 392 
ILE HXT    H  N N 393 
LEU N      N  N N 394 
LEU CA     C  N S 395 
LEU C      C  N N 396 
LEU O      O  N N 397 
LEU CB     C  N N 398 
LEU CG     C  N N 399 
LEU CD1    C  N N 400 
LEU CD2    C  N N 401 
LEU OXT    O  N N 402 
LEU H      H  N N 403 
LEU H2     H  N N 404 
LEU HA     H  N N 405 
LEU HB2    H  N N 406 
LEU HB3    H  N N 407 
LEU HG     H  N N 408 
LEU HD11   H  N N 409 
LEU HD12   H  N N 410 
LEU HD13   H  N N 411 
LEU HD21   H  N N 412 
LEU HD22   H  N N 413 
LEU HD23   H  N N 414 
LEU HXT    H  N N 415 
LYS N      N  N N 416 
LYS CA     C  N S 417 
LYS C      C  N N 418 
LYS O      O  N N 419 
LYS CB     C  N N 420 
LYS CG     C  N N 421 
LYS CD     C  N N 422 
LYS CE     C  N N 423 
LYS NZ     N  N N 424 
LYS OXT    O  N N 425 
LYS H      H  N N 426 
LYS H2     H  N N 427 
LYS HA     H  N N 428 
LYS HB2    H  N N 429 
LYS HB3    H  N N 430 
LYS HG2    H  N N 431 
LYS HG3    H  N N 432 
LYS HD2    H  N N 433 
LYS HD3    H  N N 434 
LYS HE2    H  N N 435 
LYS HE3    H  N N 436 
LYS HZ1    H  N N 437 
LYS HZ2    H  N N 438 
LYS HZ3    H  N N 439 
LYS HXT    H  N N 440 
MET N      N  N N 441 
MET CA     C  N S 442 
MET C      C  N N 443 
MET O      O  N N 444 
MET CB     C  N N 445 
MET CG     C  N N 446 
MET SD     S  N N 447 
MET CE     C  N N 448 
MET OXT    O  N N 449 
MET H      H  N N 450 
MET H2     H  N N 451 
MET HA     H  N N 452 
MET HB2    H  N N 453 
MET HB3    H  N N 454 
MET HG2    H  N N 455 
MET HG3    H  N N 456 
MET HE1    H  N N 457 
MET HE2    H  N N 458 
MET HE3    H  N N 459 
MET HXT    H  N N 460 
PHE N      N  N N 461 
PHE CA     C  N S 462 
PHE C      C  N N 463 
PHE O      O  N N 464 
PHE CB     C  N N 465 
PHE CG     C  Y N 466 
PHE CD1    C  Y N 467 
PHE CD2    C  Y N 468 
PHE CE1    C  Y N 469 
PHE CE2    C  Y N 470 
PHE CZ     C  Y N 471 
PHE OXT    O  N N 472 
PHE H      H  N N 473 
PHE H2     H  N N 474 
PHE HA     H  N N 475 
PHE HB2    H  N N 476 
PHE HB3    H  N N 477 
PHE HD1    H  N N 478 
PHE HD2    H  N N 479 
PHE HE1    H  N N 480 
PHE HE2    H  N N 481 
PHE HZ     H  N N 482 
PHE HXT    H  N N 483 
PRO N      N  N N 484 
PRO CA     C  N S 485 
PRO C      C  N N 486 
PRO O      O  N N 487 
PRO CB     C  N N 488 
PRO CG     C  N N 489 
PRO CD     C  N N 490 
PRO OXT    O  N N 491 
PRO H      H  N N 492 
PRO HA     H  N N 493 
PRO HB2    H  N N 494 
PRO HB3    H  N N 495 
PRO HG2    H  N N 496 
PRO HG3    H  N N 497 
PRO HD2    H  N N 498 
PRO HD3    H  N N 499 
PRO HXT    H  N N 500 
SER N      N  N N 501 
SER CA     C  N S 502 
SER C      C  N N 503 
SER O      O  N N 504 
SER CB     C  N N 505 
SER OG     O  N N 506 
SER OXT    O  N N 507 
SER H      H  N N 508 
SER H2     H  N N 509 
SER HA     H  N N 510 
SER HB2    H  N N 511 
SER HB3    H  N N 512 
SER HG     H  N N 513 
SER HXT    H  N N 514 
THR N      N  N N 515 
THR CA     C  N S 516 
THR C      C  N N 517 
THR O      O  N N 518 
THR CB     C  N R 519 
THR OG1    O  N N 520 
THR CG2    C  N N 521 
THR OXT    O  N N 522 
THR H      H  N N 523 
THR H2     H  N N 524 
THR HA     H  N N 525 
THR HB     H  N N 526 
THR HG1    H  N N 527 
THR HG21   H  N N 528 
THR HG22   H  N N 529 
THR HG23   H  N N 530 
THR HXT    H  N N 531 
TRP N      N  N N 532 
TRP CA     C  N S 533 
TRP C      C  N N 534 
TRP O      O  N N 535 
TRP CB     C  N N 536 
TRP CG     C  Y N 537 
TRP CD1    C  Y N 538 
TRP CD2    C  Y N 539 
TRP NE1    N  Y N 540 
TRP CE2    C  Y N 541 
TRP CE3    C  Y N 542 
TRP CZ2    C  Y N 543 
TRP CZ3    C  Y N 544 
TRP CH2    C  Y N 545 
TRP OXT    O  N N 546 
TRP H      H  N N 547 
TRP H2     H  N N 548 
TRP HA     H  N N 549 
TRP HB2    H  N N 550 
TRP HB3    H  N N 551 
TRP HD1    H  N N 552 
TRP HE1    H  N N 553 
TRP HE3    H  N N 554 
TRP HZ2    H  N N 555 
TRP HZ3    H  N N 556 
TRP HH2    H  N N 557 
TRP HXT    H  N N 558 
TYR N      N  N N 559 
TYR CA     C  N S 560 
TYR C      C  N N 561 
TYR O      O  N N 562 
TYR CB     C  N N 563 
TYR CG     C  Y N 564 
TYR CD1    C  Y N 565 
TYR CD2    C  Y N 566 
TYR CE1    C  Y N 567 
TYR CE2    C  Y N 568 
TYR CZ     C  Y N 569 
TYR OH     O  N N 570 
TYR OXT    O  N N 571 
TYR H      H  N N 572 
TYR H2     H  N N 573 
TYR HA     H  N N 574 
TYR HB2    H  N N 575 
TYR HB3    H  N N 576 
TYR HD1    H  N N 577 
TYR HD2    H  N N 578 
TYR HE1    H  N N 579 
TYR HE2    H  N N 580 
TYR HH     H  N N 581 
TYR HXT    H  N N 582 
VAL N      N  N N 583 
VAL CA     C  N S 584 
VAL C      C  N N 585 
VAL O      O  N N 586 
VAL CB     C  N N 587 
VAL CG1    C  N N 588 
VAL CG2    C  N N 589 
VAL OXT    O  N N 590 
VAL H      H  N N 591 
VAL H2     H  N N 592 
VAL HA     H  N N 593 
VAL HB     H  N N 594 
VAL HG11   H  N N 595 
VAL HG12   H  N N 596 
VAL HG13   H  N N 597 
VAL HG21   H  N N 598 
VAL HG22   H  N N 599 
VAL HG23   H  N N 600 
VAL HXT    H  N N 601 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
5AD N1    C2     doub Y N 1   
5AD N1    C6     sing Y N 2   
5AD C2    N3     sing Y N 3   
5AD C2    H2     sing N N 4   
5AD N3    C4     doub Y N 5   
5AD C4    N9     sing Y N 6   
5AD C4    C5     sing Y N 7   
5AD N9    C8     sing Y N 8   
5AD N9    "C1'"  sing N N 9   
5AD C8    N7     doub Y N 10  
5AD C8    H8     sing N N 11  
5AD N7    C5     sing Y N 12  
5AD C5    C6     doub Y N 13  
5AD C6    N6     sing N N 14  
5AD N6    HN61   sing N N 15  
5AD N6    HN62   sing N N 16  
5AD "C1'" "C2'"  sing N N 17  
5AD "C1'" "O4'"  sing N N 18  
5AD "C1'" "H1'"  sing N N 19  
5AD "C2'" "C3'"  sing N N 20  
5AD "C2'" "O2'"  sing N N 21  
5AD "C2'" "H2'"  sing N N 22  
5AD "C3'" "C4'"  sing N N 23  
5AD "C3'" "O3'"  sing N N 24  
5AD "C3'" "H3'"  sing N N 25  
5AD "C4'" "C5'"  sing N N 26  
5AD "C4'" "O4'"  sing N N 27  
5AD "C4'" "H4'"  sing N N 28  
5AD "C5'" "H5'1" sing N N 29  
5AD "C5'" "H5'2" sing N N 30  
5AD "C5'" "H5'3" sing N N 31  
5AD "O2'" "HO2'" sing N N 32  
5AD "O3'" "HO3'" sing N N 33  
ALA N     CA     sing N N 34  
ALA N     H      sing N N 35  
ALA N     H2     sing N N 36  
ALA CA    C      sing N N 37  
ALA CA    CB     sing N N 38  
ALA CA    HA     sing N N 39  
ALA C     O      doub N N 40  
ALA C     OXT    sing N N 41  
ALA CB    HB1    sing N N 42  
ALA CB    HB2    sing N N 43  
ALA CB    HB3    sing N N 44  
ALA OXT   HXT    sing N N 45  
ARG N     CA     sing N N 46  
ARG N     H      sing N N 47  
ARG N     H2     sing N N 48  
ARG CA    C      sing N N 49  
ARG CA    CB     sing N N 50  
ARG CA    HA     sing N N 51  
ARG C     O      doub N N 52  
ARG C     OXT    sing N N 53  
ARG CB    CG     sing N N 54  
ARG CB    HB2    sing N N 55  
ARG CB    HB3    sing N N 56  
ARG CG    CD     sing N N 57  
ARG CG    HG2    sing N N 58  
ARG CG    HG3    sing N N 59  
ARG CD    NE     sing N N 60  
ARG CD    HD2    sing N N 61  
ARG CD    HD3    sing N N 62  
ARG NE    CZ     sing N N 63  
ARG NE    HE     sing N N 64  
ARG CZ    NH1    sing N N 65  
ARG CZ    NH2    doub N N 66  
ARG NH1   HH11   sing N N 67  
ARG NH1   HH12   sing N N 68  
ARG NH2   HH21   sing N N 69  
ARG NH2   HH22   sing N N 70  
ARG OXT   HXT    sing N N 71  
ASN N     CA     sing N N 72  
ASN N     H      sing N N 73  
ASN N     H2     sing N N 74  
ASN CA    C      sing N N 75  
ASN CA    CB     sing N N 76  
ASN CA    HA     sing N N 77  
ASN C     O      doub N N 78  
ASN C     OXT    sing N N 79  
ASN CB    CG     sing N N 80  
ASN CB    HB2    sing N N 81  
ASN CB    HB3    sing N N 82  
ASN CG    OD1    doub N N 83  
ASN CG    ND2    sing N N 84  
ASN ND2   HD21   sing N N 85  
ASN ND2   HD22   sing N N 86  
ASN OXT   HXT    sing N N 87  
ASP N     CA     sing N N 88  
ASP N     H      sing N N 89  
ASP N     H2     sing N N 90  
ASP CA    C      sing N N 91  
ASP CA    CB     sing N N 92  
ASP CA    HA     sing N N 93  
ASP C     O      doub N N 94  
ASP C     OXT    sing N N 95  
ASP CB    CG     sing N N 96  
ASP CB    HB2    sing N N 97  
ASP CB    HB3    sing N N 98  
ASP CG    OD1    doub N N 99  
ASP CG    OD2    sing N N 100 
ASP OD2   HD2    sing N N 101 
ASP OXT   HXT    sing N N 102 
B12 N21   CO     sing N N 103 
B12 N21   C1     sing N N 104 
B12 N21   C4     doub N N 105 
B12 N22   CO     sing N N 106 
B12 N22   C6     sing N N 107 
B12 N22   C9     doub N N 108 
B12 N23   CO     sing N N 109 
B12 N23   C11    sing N N 110 
B12 N23   C14    sing N N 111 
B12 N24   CO     sing N N 112 
B12 N24   C16    doub N N 113 
B12 N24   C19    sing N N 114 
B12 C1    C20    sing N N 115 
B12 C1    C2     sing N N 116 
B12 C1    C19    sing N N 117 
B12 C20   H201   sing N N 118 
B12 C20   H202   sing N N 119 
B12 C20   H203   sing N N 120 
B12 C2    C25    sing N N 121 
B12 C2    C26    sing N N 122 
B12 C2    C3     sing N N 123 
B12 C25   H251   sing N N 124 
B12 C25   H252   sing N N 125 
B12 C25   H253   sing N N 126 
B12 C26   C27    sing N N 127 
B12 C26   H261   sing N N 128 
B12 C26   H262   sing N N 129 
B12 C27   O28    doub N N 130 
B12 C27   N29    sing N N 131 
B12 N29   H291   sing N N 132 
B12 N29   H292   sing N N 133 
B12 C3    C30    sing N N 134 
B12 C3    C4     sing N N 135 
B12 C3    H3     sing N N 136 
B12 C30   C31    sing N N 137 
B12 C30   H301   sing N N 138 
B12 C30   H302   sing N N 139 
B12 C31   C32    sing N N 140 
B12 C31   H311   sing N N 141 
B12 C31   H312   sing N N 142 
B12 C32   O34    doub N N 143 
B12 C32   N33    sing N N 144 
B12 N33   H331   sing N N 145 
B12 N33   H332   sing N N 146 
B12 C4    C5     sing N N 147 
B12 C5    C35    sing N N 148 
B12 C5    C6     doub N N 149 
B12 C35   H351   sing N N 150 
B12 C35   H352   sing N N 151 
B12 C35   H353   sing N N 152 
B12 C6    C7     sing N N 153 
B12 C7    C36    sing N N 154 
B12 C7    C37    sing N N 155 
B12 C7    C8     sing N N 156 
B12 C36   H361   sing N N 157 
B12 C36   H362   sing N N 158 
B12 C36   H363   sing N N 159 
B12 C37   C38    sing N N 160 
B12 C37   H371   sing N N 161 
B12 C37   H372   sing N N 162 
B12 C38   O39    doub N N 163 
B12 C38   N40    sing N N 164 
B12 N40   H401   sing N N 165 
B12 N40   H402   sing N N 166 
B12 C8    C41    sing N N 167 
B12 C8    C9     sing N N 168 
B12 C8    H8     sing N N 169 
B12 C41   C42    sing N N 170 
B12 C41   H411   sing N N 171 
B12 C41   H412   sing N N 172 
B12 C42   C43    sing N N 173 
B12 C42   H421   sing N N 174 
B12 C42   H422   sing N N 175 
B12 C43   O44    doub N N 176 
B12 C43   N45    sing N N 177 
B12 N45   H451   sing N N 178 
B12 N45   H452   sing N N 179 
B12 C9    C10    sing N N 180 
B12 C10   C11    doub N N 181 
B12 C10   H10    sing N N 182 
B12 C11   C12    sing N N 183 
B12 C12   C46    sing N N 184 
B12 C12   C47    sing N N 185 
B12 C12   C13    sing N N 186 
B12 C46   H461   sing N N 187 
B12 C46   H462   sing N N 188 
B12 C46   H463   sing N N 189 
B12 C47   H471   sing N N 190 
B12 C47   H472   sing N N 191 
B12 C47   H473   sing N N 192 
B12 C13   C48    sing N N 193 
B12 C13   C14    sing N N 194 
B12 C13   H13    sing N N 195 
B12 C48   C49    sing N N 196 
B12 C48   H481   sing N N 197 
B12 C48   H482   sing N N 198 
B12 C49   C50    sing N N 199 
B12 C49   H491   sing N N 200 
B12 C49   H492   sing N N 201 
B12 C50   O51    doub N N 202 
B12 C50   N52    sing N N 203 
B12 N52   H521   sing N N 204 
B12 N52   H522   sing N N 205 
B12 C14   C15    doub N N 206 
B12 C15   C53    sing N N 207 
B12 C15   C16    sing N N 208 
B12 C53   H531   sing N N 209 
B12 C53   H532   sing N N 210 
B12 C53   H533   sing N N 211 
B12 C16   C17    sing N N 212 
B12 C17   C54    sing N N 213 
B12 C17   C55    sing N N 214 
B12 C17   C18    sing N N 215 
B12 C54   H541   sing N N 216 
B12 C54   H542   sing N N 217 
B12 C54   H543   sing N N 218 
B12 C55   C56    sing N N 219 
B12 C55   H551   sing N N 220 
B12 C55   H552   sing N N 221 
B12 C56   C57    sing N N 222 
B12 C56   H561   sing N N 223 
B12 C56   H562   sing N N 224 
B12 C57   O58    doub N N 225 
B12 C57   N59    sing N N 226 
B12 N59   C1P    sing N N 227 
B12 N59   H59    sing N N 228 
B12 C18   C60    sing N N 229 
B12 C18   C19    sing N N 230 
B12 C18   H18    sing N N 231 
B12 C60   C61    sing N N 232 
B12 C60   H601   sing N N 233 
B12 C60   H602   sing N N 234 
B12 C61   O63    doub N N 235 
B12 C61   N62    sing N N 236 
B12 N62   H621   sing N N 237 
B12 N62   H622   sing N N 238 
B12 C19   H91    sing N N 239 
B12 C1P   C2P    sing N N 240 
B12 C1P   H1P1   sing N N 241 
B12 C1P   H1P2   sing N N 242 
B12 C2P   C3P    sing N N 243 
B12 C2P   O3     sing N N 244 
B12 C2P   H2P    sing N N 245 
B12 C3P   H3P1   sing N N 246 
B12 C3P   H3P2   sing N N 247 
B12 C3P   H3P3   sing N N 248 
B12 O3    P      sing N N 249 
B12 O4    P      doub N N 250 
B12 O5    P      sing N N 251 
B12 O5    HOP5   sing N N 252 
B12 P     O2     sing N N 253 
B12 O2    C3R    sing N N 254 
B12 C3R   C2R    sing N N 255 
B12 C3R   C4R    sing N N 256 
B12 C3R   H3R    sing N N 257 
B12 C2R   O7R    sing N N 258 
B12 C2R   C1R    sing N N 259 
B12 C2R   H2R    sing N N 260 
B12 O7R   HOR7   sing N N 261 
B12 C1R   O6R    sing N N 262 
B12 C1R   N1B    sing N N 263 
B12 C1R   H1R    sing N N 264 
B12 O6R   C4R    sing N N 265 
B12 C4R   C5R    sing N N 266 
B12 C4R   H4R    sing N N 267 
B12 C5R   O8R    sing N N 268 
B12 C5R   H5R1   sing N N 269 
B12 C5R   H5R2   sing N N 270 
B12 O8R   HOR8   sing N N 271 
B12 N1B   C8B    sing Y N 272 
B12 N1B   C2B    sing Y N 273 
B12 C8B   C9B    doub Y N 274 
B12 C8B   C7B    sing Y N 275 
B12 C2B   N3B    doub Y N 276 
B12 C2B   H2B    sing N N 277 
B12 N3B   C9B    sing Y N 278 
B12 C9B   C4B    sing Y N 279 
B12 C4B   C5B    doub Y N 280 
B12 C4B   H4B    sing N N 281 
B12 C5B   C5M    sing N N 282 
B12 C5B   C6B    sing Y N 283 
B12 C5M   HM51   sing N N 284 
B12 C5M   HM52   sing N N 285 
B12 C5M   HM53   sing N N 286 
B12 C6B   C6M    sing N N 287 
B12 C6B   C7B    doub Y N 288 
B12 C6M   HM61   sing N N 289 
B12 C6M   HM62   sing N N 290 
B12 C6M   HM63   sing N N 291 
B12 C7B   H7B    sing N N 292 
CYS N     CA     sing N N 293 
CYS N     H      sing N N 294 
CYS N     H2     sing N N 295 
CYS CA    C      sing N N 296 
CYS CA    CB     sing N N 297 
CYS CA    HA     sing N N 298 
CYS C     O      doub N N 299 
CYS C     OXT    sing N N 300 
CYS CB    SG     sing N N 301 
CYS CB    HB2    sing N N 302 
CYS CB    HB3    sing N N 303 
CYS SG    HG     sing N N 304 
CYS OXT   HXT    sing N N 305 
GLN N     CA     sing N N 306 
GLN N     H      sing N N 307 
GLN N     H2     sing N N 308 
GLN CA    C      sing N N 309 
GLN CA    CB     sing N N 310 
GLN CA    HA     sing N N 311 
GLN C     O      doub N N 312 
GLN C     OXT    sing N N 313 
GLN CB    CG     sing N N 314 
GLN CB    HB2    sing N N 315 
GLN CB    HB3    sing N N 316 
GLN CG    CD     sing N N 317 
GLN CG    HG2    sing N N 318 
GLN CG    HG3    sing N N 319 
GLN CD    OE1    doub N N 320 
GLN CD    NE2    sing N N 321 
GLN NE2   HE21   sing N N 322 
GLN NE2   HE22   sing N N 323 
GLN OXT   HXT    sing N N 324 
GLU N     CA     sing N N 325 
GLU N     H      sing N N 326 
GLU N     H2     sing N N 327 
GLU CA    C      sing N N 328 
GLU CA    CB     sing N N 329 
GLU CA    HA     sing N N 330 
GLU C     O      doub N N 331 
GLU C     OXT    sing N N 332 
GLU CB    CG     sing N N 333 
GLU CB    HB2    sing N N 334 
GLU CB    HB3    sing N N 335 
GLU CG    CD     sing N N 336 
GLU CG    HG2    sing N N 337 
GLU CG    HG3    sing N N 338 
GLU CD    OE1    doub N N 339 
GLU CD    OE2    sing N N 340 
GLU OE2   HE2    sing N N 341 
GLU OXT   HXT    sing N N 342 
GLY N     CA     sing N N 343 
GLY N     H      sing N N 344 
GLY N     H2     sing N N 345 
GLY CA    C      sing N N 346 
GLY CA    HA2    sing N N 347 
GLY CA    HA3    sing N N 348 
GLY C     O      doub N N 349 
GLY C     OXT    sing N N 350 
GLY OXT   HXT    sing N N 351 
HIS N     CA     sing N N 352 
HIS N     H      sing N N 353 
HIS N     H2     sing N N 354 
HIS CA    C      sing N N 355 
HIS CA    CB     sing N N 356 
HIS CA    HA     sing N N 357 
HIS C     O      doub N N 358 
HIS C     OXT    sing N N 359 
HIS CB    CG     sing N N 360 
HIS CB    HB2    sing N N 361 
HIS CB    HB3    sing N N 362 
HIS CG    ND1    sing Y N 363 
HIS CG    CD2    doub Y N 364 
HIS ND1   CE1    doub Y N 365 
HIS ND1   HD1    sing N N 366 
HIS CD2   NE2    sing Y N 367 
HIS CD2   HD2    sing N N 368 
HIS CE1   NE2    sing Y N 369 
HIS CE1   HE1    sing N N 370 
HIS NE2   HE2    sing N N 371 
HIS OXT   HXT    sing N N 372 
HOH O     H1     sing N N 373 
HOH O     H2     sing N N 374 
ILE N     CA     sing N N 375 
ILE N     H      sing N N 376 
ILE N     H2     sing N N 377 
ILE CA    C      sing N N 378 
ILE CA    CB     sing N N 379 
ILE CA    HA     sing N N 380 
ILE C     O      doub N N 381 
ILE C     OXT    sing N N 382 
ILE CB    CG1    sing N N 383 
ILE CB    CG2    sing N N 384 
ILE CB    HB     sing N N 385 
ILE CG1   CD1    sing N N 386 
ILE CG1   HG12   sing N N 387 
ILE CG1   HG13   sing N N 388 
ILE CG2   HG21   sing N N 389 
ILE CG2   HG22   sing N N 390 
ILE CG2   HG23   sing N N 391 
ILE CD1   HD11   sing N N 392 
ILE CD1   HD12   sing N N 393 
ILE CD1   HD13   sing N N 394 
ILE OXT   HXT    sing N N 395 
LEU N     CA     sing N N 396 
LEU N     H      sing N N 397 
LEU N     H2     sing N N 398 
LEU CA    C      sing N N 399 
LEU CA    CB     sing N N 400 
LEU CA    HA     sing N N 401 
LEU C     O      doub N N 402 
LEU C     OXT    sing N N 403 
LEU CB    CG     sing N N 404 
LEU CB    HB2    sing N N 405 
LEU CB    HB3    sing N N 406 
LEU CG    CD1    sing N N 407 
LEU CG    CD2    sing N N 408 
LEU CG    HG     sing N N 409 
LEU CD1   HD11   sing N N 410 
LEU CD1   HD12   sing N N 411 
LEU CD1   HD13   sing N N 412 
LEU CD2   HD21   sing N N 413 
LEU CD2   HD22   sing N N 414 
LEU CD2   HD23   sing N N 415 
LEU OXT   HXT    sing N N 416 
LYS N     CA     sing N N 417 
LYS N     H      sing N N 418 
LYS N     H2     sing N N 419 
LYS CA    C      sing N N 420 
LYS CA    CB     sing N N 421 
LYS CA    HA     sing N N 422 
LYS C     O      doub N N 423 
LYS C     OXT    sing N N 424 
LYS CB    CG     sing N N 425 
LYS CB    HB2    sing N N 426 
LYS CB    HB3    sing N N 427 
LYS CG    CD     sing N N 428 
LYS CG    HG2    sing N N 429 
LYS CG    HG3    sing N N 430 
LYS CD    CE     sing N N 431 
LYS CD    HD2    sing N N 432 
LYS CD    HD3    sing N N 433 
LYS CE    NZ     sing N N 434 
LYS CE    HE2    sing N N 435 
LYS CE    HE3    sing N N 436 
LYS NZ    HZ1    sing N N 437 
LYS NZ    HZ2    sing N N 438 
LYS NZ    HZ3    sing N N 439 
LYS OXT   HXT    sing N N 440 
MET N     CA     sing N N 441 
MET N     H      sing N N 442 
MET N     H2     sing N N 443 
MET CA    C      sing N N 444 
MET CA    CB     sing N N 445 
MET CA    HA     sing N N 446 
MET C     O      doub N N 447 
MET C     OXT    sing N N 448 
MET CB    CG     sing N N 449 
MET CB    HB2    sing N N 450 
MET CB    HB3    sing N N 451 
MET CG    SD     sing N N 452 
MET CG    HG2    sing N N 453 
MET CG    HG3    sing N N 454 
MET SD    CE     sing N N 455 
MET CE    HE1    sing N N 456 
MET CE    HE2    sing N N 457 
MET CE    HE3    sing N N 458 
MET OXT   HXT    sing N N 459 
PHE N     CA     sing N N 460 
PHE N     H      sing N N 461 
PHE N     H2     sing N N 462 
PHE CA    C      sing N N 463 
PHE CA    CB     sing N N 464 
PHE CA    HA     sing N N 465 
PHE C     O      doub N N 466 
PHE C     OXT    sing N N 467 
PHE CB    CG     sing N N 468 
PHE CB    HB2    sing N N 469 
PHE CB    HB3    sing N N 470 
PHE CG    CD1    doub Y N 471 
PHE CG    CD2    sing Y N 472 
PHE CD1   CE1    sing Y N 473 
PHE CD1   HD1    sing N N 474 
PHE CD2   CE2    doub Y N 475 
PHE CD2   HD2    sing N N 476 
PHE CE1   CZ     doub Y N 477 
PHE CE1   HE1    sing N N 478 
PHE CE2   CZ     sing Y N 479 
PHE CE2   HE2    sing N N 480 
PHE CZ    HZ     sing N N 481 
PHE OXT   HXT    sing N N 482 
PRO N     CA     sing N N 483 
PRO N     CD     sing N N 484 
PRO N     H      sing N N 485 
PRO CA    C      sing N N 486 
PRO CA    CB     sing N N 487 
PRO CA    HA     sing N N 488 
PRO C     O      doub N N 489 
PRO C     OXT    sing N N 490 
PRO CB    CG     sing N N 491 
PRO CB    HB2    sing N N 492 
PRO CB    HB3    sing N N 493 
PRO CG    CD     sing N N 494 
PRO CG    HG2    sing N N 495 
PRO CG    HG3    sing N N 496 
PRO CD    HD2    sing N N 497 
PRO CD    HD3    sing N N 498 
PRO OXT   HXT    sing N N 499 
SER N     CA     sing N N 500 
SER N     H      sing N N 501 
SER N     H2     sing N N 502 
SER CA    C      sing N N 503 
SER CA    CB     sing N N 504 
SER CA    HA     sing N N 505 
SER C     O      doub N N 506 
SER C     OXT    sing N N 507 
SER CB    OG     sing N N 508 
SER CB    HB2    sing N N 509 
SER CB    HB3    sing N N 510 
SER OG    HG     sing N N 511 
SER OXT   HXT    sing N N 512 
THR N     CA     sing N N 513 
THR N     H      sing N N 514 
THR N     H2     sing N N 515 
THR CA    C      sing N N 516 
THR CA    CB     sing N N 517 
THR CA    HA     sing N N 518 
THR C     O      doub N N 519 
THR C     OXT    sing N N 520 
THR CB    OG1    sing N N 521 
THR CB    CG2    sing N N 522 
THR CB    HB     sing N N 523 
THR OG1   HG1    sing N N 524 
THR CG2   HG21   sing N N 525 
THR CG2   HG22   sing N N 526 
THR CG2   HG23   sing N N 527 
THR OXT   HXT    sing N N 528 
TRP N     CA     sing N N 529 
TRP N     H      sing N N 530 
TRP N     H2     sing N N 531 
TRP CA    C      sing N N 532 
TRP CA    CB     sing N N 533 
TRP CA    HA     sing N N 534 
TRP C     O      doub N N 535 
TRP C     OXT    sing N N 536 
TRP CB    CG     sing N N 537 
TRP CB    HB2    sing N N 538 
TRP CB    HB3    sing N N 539 
TRP CG    CD1    doub Y N 540 
TRP CG    CD2    sing Y N 541 
TRP CD1   NE1    sing Y N 542 
TRP CD1   HD1    sing N N 543 
TRP CD2   CE2    doub Y N 544 
TRP CD2   CE3    sing Y N 545 
TRP NE1   CE2    sing Y N 546 
TRP NE1   HE1    sing N N 547 
TRP CE2   CZ2    sing Y N 548 
TRP CE3   CZ3    doub Y N 549 
TRP CE3   HE3    sing N N 550 
TRP CZ2   CH2    doub Y N 551 
TRP CZ2   HZ2    sing N N 552 
TRP CZ3   CH2    sing Y N 553 
TRP CZ3   HZ3    sing N N 554 
TRP CH2   HH2    sing N N 555 
TRP OXT   HXT    sing N N 556 
TYR N     CA     sing N N 557 
TYR N     H      sing N N 558 
TYR N     H2     sing N N 559 
TYR CA    C      sing N N 560 
TYR CA    CB     sing N N 561 
TYR CA    HA     sing N N 562 
TYR C     O      doub N N 563 
TYR C     OXT    sing N N 564 
TYR CB    CG     sing N N 565 
TYR CB    HB2    sing N N 566 
TYR CB    HB3    sing N N 567 
TYR CG    CD1    doub Y N 568 
TYR CG    CD2    sing Y N 569 
TYR CD1   CE1    sing Y N 570 
TYR CD1   HD1    sing N N 571 
TYR CD2   CE2    doub Y N 572 
TYR CD2   HD2    sing N N 573 
TYR CE1   CZ     doub Y N 574 
TYR CE1   HE1    sing N N 575 
TYR CE2   CZ     sing Y N 576 
TYR CE2   HE2    sing N N 577 
TYR CZ    OH     sing N N 578 
TYR OH    HH     sing N N 579 
TYR OXT   HXT    sing N N 580 
VAL N     CA     sing N N 581 
VAL N     H      sing N N 582 
VAL N     H2     sing N N 583 
VAL CA    C      sing N N 584 
VAL CA    CB     sing N N 585 
VAL CA    HA     sing N N 586 
VAL C     O      doub N N 587 
VAL C     OXT    sing N N 588 
VAL CB    CG1    sing N N 589 
VAL CB    CG2    sing N N 590 
VAL CB    HB     sing N N 591 
VAL CG1   HG11   sing N N 592 
VAL CG1   HG12   sing N N 593 
VAL CG1   HG13   sing N N 594 
VAL CG2   HG21   sing N N 595 
VAL CG2   HG22   sing N N 596 
VAL CG2   HG23   sing N N 597 
VAL OXT   HXT    sing N N 598 
# 
_pdbx_audit_support.funding_organization   'Engineering and Physical Sciences Research Council' 
_pdbx_audit_support.country                'United Kingdom' 
_pdbx_audit_support.grant_number           EP/S030336/1 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'in silico model' 
_pdbx_initial_refinement_model.source_name      AlphaFold 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8JBS 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.007986 
_atom_sites.fract_transf_matrix[1][2]   0.004611 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   -0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.009222 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   -0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.013682 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
CO 
H  
N  
O  
P  
S  
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N     . VAL A 1 91  ? 24.736 -43.321 -8.250  1.00 118.89 ? 9   VAL A N     1 
ATOM   2    C  CA    . VAL A 1 91  ? 24.347 -42.806 -9.602  1.00 131.00 ? 9   VAL A CA    1 
ATOM   3    C  C     . VAL A 1 91  ? 25.615 -42.446 -10.393 1.00 134.23 ? 9   VAL A C     1 
ATOM   4    O  O     . VAL A 1 91  ? 25.648 -42.642 -11.606 1.00 108.37 ? 9   VAL A O     1 
ATOM   5    C  CB    . VAL A 1 91  ? 23.293 -41.664 -9.537  1.00 127.25 ? 9   VAL A CB    1 
ATOM   6    C  CG1   . VAL A 1 91  ? 21.961 -42.152 -8.959  1.00 112.89 ? 9   VAL A CG1   1 
ATOM   7    C  CG2   . VAL A 1 91  ? 23.750 -40.417 -8.774  1.00 108.70 ? 9   VAL A CG2   1 
ATOM   8    N  N     . THR A 1 92  ? 26.685 -42.004 -9.704  1.00 148.81 ? 10  THR A N     1 
ATOM   9    C  CA    . THR A 1 92  ? 27.868 -41.437 -10.347 1.00 138.62 ? 10  THR A CA    1 
ATOM   10   C  C     . THR A 1 92  ? 29.068 -42.383 -10.251 1.00 133.32 ? 10  THR A C     1 
ATOM   11   O  O     . THR A 1 92  ? 30.038 -42.108 -9.543  1.00 109.89 ? 10  THR A O     1 
ATOM   12   C  CB    . THR A 1 92  ? 28.181 -40.086 -9.706  1.00 131.99 ? 10  THR A CB    1 
ATOM   13   O  OG1   . THR A 1 92  ? 26.935 -39.403 -9.632  1.00 119.93 ? 10  THR A OG1   1 
ATOM   14   C  CG2   . THR A 1 92  ? 29.154 -39.263 -10.530 1.00 129.24 ? 10  THR A CG2   1 
ATOM   15   N  N     . ALA A 1 93  ? 28.993 -43.501 -10.981 1.00 137.45 ? 11  ALA A N     1 
ATOM   16   C  CA    . ALA A 1 93  ? 30.167 -44.283 -11.344 1.00 125.03 ? 11  ALA A CA    1 
ATOM   17   C  C     . ALA A 1 93  ? 30.519 -44.013 -12.806 1.00 127.24 ? 11  ALA A C     1 
ATOM   18   O  O     . ALA A 1 93  ? 31.426 -44.642 -13.340 1.00 141.73 ? 11  ALA A O     1 
ATOM   19   C  CB    . ALA A 1 93  ? 29.926 -45.762 -11.105 1.00 115.66 ? 11  ALA A CB    1 
ATOM   20   N  N     . SER A 1 94  ? 29.790 -43.083 -13.445 1.00 128.74 ? 12  SER A N     1 
ATOM   21   C  CA    . SER A 1 94  ? 30.079 -42.625 -14.799 1.00 110.14 ? 12  SER A CA    1 
ATOM   22   C  C     . SER A 1 94  ? 31.284 -41.689 -14.808 1.00 112.09 ? 12  SER A C     1 
ATOM   23   O  O     . SER A 1 94  ? 31.913 -41.482 -15.847 1.00 90.05  ? 12  SER A O     1 
ATOM   24   C  CB    . SER A 1 94  ? 28.900 -41.919 -15.388 1.00 108.62 ? 12  SER A CB    1 
ATOM   25   O  OG    . SER A 1 94  ? 29.309 -41.189 -16.535 1.00 95.18  ? 12  SER A OG    1 
ATOM   26   N  N     . LEU A 1 95  ? 31.540 -41.071 -13.648 1.00 119.96 ? 13  LEU A N     1 
ATOM   27   C  CA    . LEU A 1 95  ? 32.841 -40.495 -13.351 1.00 127.86 ? 13  LEU A CA    1 
ATOM   28   C  C     . LEU A 1 95  ? 33.917 -41.535 -13.658 1.00 121.96 ? 13  LEU A C     1 
ATOM   29   O  O     . LEU A 1 95  ? 34.804 -41.278 -14.472 1.00 117.18 ? 13  LEU A O     1 
ATOM   30   C  CB    . LEU A 1 95  ? 32.877 -40.036 -11.887 1.00 132.24 ? 13  LEU A CB    1 
ATOM   31   C  CG    . LEU A 1 95  ? 34.123 -39.279 -11.392 1.00 115.25 ? 13  LEU A CG    1 
ATOM   32   C  CD1   . LEU A 1 95  ? 35.206 -40.188 -10.822 1.00 101.93 ? 13  LEU A CD1   1 
ATOM   33   C  CD2   . LEU A 1 95  ? 34.721 -38.396 -12.478 1.00 115.00 ? 13  LEU A CD2   1 
ATOM   34   N  N     . ASP A 1 96  ? 33.782 -42.724 -13.044 1.00 110.63 ? 14  ASP A N     1 
ATOM   35   C  CA    . ASP A 1 96  ? 34.812 -43.757 -13.049 1.00 99.84  ? 14  ASP A CA    1 
ATOM   36   C  C     . ASP A 1 96  ? 35.037 -44.310 -14.461 1.00 85.69  ? 14  ASP A C     1 
ATOM   37   O  O     . ASP A 1 96  ? 36.081 -44.899 -14.744 1.00 83.23  ? 14  ASP A O     1 
ATOM   38   C  CB    . ASP A 1 96  ? 34.493 -44.835 -12.024 1.00 101.27 ? 14  ASP A CB    1 
ATOM   39   C  CG    . ASP A 1 96  ? 35.671 -45.361 -11.213 1.00 103.14 ? 14  ASP A CG    1 
ATOM   40   O  OD1   . ASP A 1 96  ? 36.836 -45.209 -11.645 1.00 91.08  ? 14  ASP A OD1   1 
ATOM   41   O  OD2   . ASP A 1 96  ? 35.415 -45.892 -10.122 1.00 106.54 ? 14  ASP A OD2   1 
ATOM   42   N  N     . GLN A 1 97  ? 34.069 -44.105 -15.358 1.00 83.54  ? 15  GLN A N     1 
ATOM   43   C  CA    . GLN A 1 97  ? 34.207 -44.519 -16.745 1.00 98.01  ? 15  GLN A CA    1 
ATOM   44   C  C     . GLN A 1 97  ? 34.961 -43.462 -17.550 1.00 88.47  ? 15  GLN A C     1 
ATOM   45   O  O     . GLN A 1 97  ? 35.572 -43.769 -18.574 1.00 75.54  ? 15  GLN A O     1 
ATOM   46   C  CB    . GLN A 1 97  ? 32.820 -44.757 -17.341 1.00 109.94 ? 15  GLN A CB    1 
ATOM   47   C  CG    . GLN A 1 97  ? 32.843 -45.341 -18.750 1.00 110.82 ? 15  GLN A CG    1 
ATOM   48   C  CD    . GLN A 1 97  ? 31.458 -45.455 -19.347 1.00 121.50 ? 15  GLN A CD    1 
ATOM   49   O  OE1   . GLN A 1 97  ? 30.569 -46.106 -18.786 1.00 132.72 ? 15  GLN A OE1   1 
ATOM   50   N  NE2   . GLN A 1 97  ? 31.251 -44.803 -20.481 1.00 115.81 ? 15  GLN A NE2   1 
ATOM   51   N  N     . ALA A 1 98  ? 34.861 -42.203 -17.110 1.00 93.48  ? 16  ALA A N     1 
ATOM   52   C  CA    . ALA A 1 98  ? 35.646 -41.121 -17.682 1.00 89.06  ? 16  ALA A CA    1 
ATOM   53   C  C     . ALA A 1 98  ? 37.128 -41.305 -17.350 1.00 88.26  ? 16  ALA A C     1 
ATOM   54   O  O     . ALA A 1 98  ? 37.982 -41.099 -18.212 1.00 91.53  ? 16  ALA A O     1 
ATOM   55   C  CB    . ALA A 1 98  ? 35.121 -39.808 -17.170 1.00 89.83  ? 16  ALA A CB    1 
ATOM   56   N  N     . LEU A 1 99  ? 37.413 -41.722 -16.107 1.00 74.08  ? 17  LEU A N     1 
ATOM   57   C  CA    . LEU A 1 99  ? 38.771 -41.968 -15.640 1.00 87.68  ? 17  LEU A CA    1 
ATOM   58   C  C     . LEU A 1 99  ? 39.434 -43.068 -16.474 1.00 91.79  ? 17  LEU A C     1 
ATOM   59   O  O     . LEU A 1 99  ? 40.569 -42.901 -16.918 1.00 102.10 ? 17  LEU A O     1 
ATOM   60   C  CB    . LEU A 1 99  ? 38.802 -42.314 -14.143 1.00 85.93  ? 17  LEU A CB    1 
ATOM   61   C  CG    . LEU A 1 99  ? 38.746 -41.144 -13.149 1.00 90.99  ? 17  LEU A CG    1 
ATOM   62   C  CD1   . LEU A 1 99  ? 37.482 -40.324 -13.311 1.00 99.52  ? 17  LEU A CD1   1 
ATOM   63   C  CD2   . LEU A 1 99  ? 38.839 -41.603 -11.702 1.00 93.59  ? 17  LEU A CD2   1 
ATOM   64   N  N     . VAL A 1 100 ? 38.731 -44.193 -16.654 1.00 96.38  ? 18  VAL A N     1 
ATOM   65   C  CA    . VAL A 1 100 ? 39.278 -45.374 -17.312 1.00 102.33 ? 18  VAL A CA    1 
ATOM   66   C  C     . VAL A 1 100 ? 39.565 -45.076 -18.784 1.00 93.22  ? 18  VAL A C     1 
ATOM   67   O  O     . VAL A 1 100 ? 40.583 -45.521 -19.306 1.00 90.21  ? 18  VAL A O     1 
ATOM   68   C  CB    . VAL A 1 100 ? 38.331 -46.586 -17.157 1.00 108.18 ? 18  VAL A CB    1 
ATOM   69   C  CG1   . VAL A 1 100 ? 38.560 -47.663 -18.217 1.00 95.90  ? 18  VAL A CG1   1 
ATOM   70   C  CG2   . VAL A 1 100 ? 38.416 -47.168 -15.749 1.00 105.34 ? 18  VAL A CG2   1 
ATOM   71   N  N     . ALA A 1 101 ? 38.666 -44.336 -19.448 1.00 83.93  ? 19  ALA A N     1 
ATOM   72   C  CA    . ALA A 1 101 ? 38.815 -44.038 -20.866 1.00 91.78  ? 19  ALA A CA    1 
ATOM   73   C  C     . ALA A 1 101 ? 39.861 -42.932 -21.092 1.00 96.37  ? 19  ALA A C     1 
ATOM   74   O  O     . ALA A 1 101 ? 40.332 -42.746 -22.219 1.00 82.35  ? 19  ALA A O     1 
ATOM   75   C  CB    . ALA A 1 101 ? 37.457 -43.692 -21.458 1.00 80.41  ? 19  ALA A CB    1 
ATOM   76   N  N     . ARG A 1 102 ? 40.249 -42.227 -20.011 1.00 91.26  ? 20  ARG A N     1 
ATOM   77   C  CA    . ARG A 1 102 ? 41.087 -41.037 -20.084 1.00 97.93  ? 20  ARG A CA    1 
ATOM   78   C  C     . ARG A 1 102 ? 40.357 -39.988 -20.928 1.00 88.88  ? 20  ARG A C     1 
ATOM   79   O  O     . ARG A 1 102 ? 40.961 -39.397 -21.826 1.00 85.26  ? 20  ARG A O     1 
ATOM   80   C  CB    . ARG A 1 102 ? 42.506 -41.292 -20.630 1.00 99.92  ? 20  ARG A CB    1 
ATOM   81   C  CG    . ARG A 1 102 ? 43.309 -42.418 -19.989 1.00 100.21 ? 20  ARG A CG    1 
ATOM   82   C  CD    . ARG A 1 102 ? 43.713 -42.119 -18.555 1.00 105.85 ? 20  ARG A CD    1 
ATOM   83   N  NE    . ARG A 1 102 ? 43.862 -43.310 -17.703 1.00 112.65 ? 20  ARG A NE    1 
ATOM   84   C  CZ    . ARG A 1 102 ? 44.915 -43.609 -16.926 1.00 112.61 ? 20  ARG A CZ    1 
ATOM   85   N  NH1   . ARG A 1 102 ? 46.038 -42.899 -17.027 1.00 105.91 ? 20  ARG A NH1   1 
ATOM   86   N  NH2   . ARG A 1 102 ? 44.842 -44.621 -16.059 1.00 88.71  ? 20  ARG A NH2   1 
ATOM   87   N  N     . ASP A 1 103 ? 39.058 -39.782 -20.636 1.00 77.49  ? 21  ASP A N     1 
ATOM   88   C  CA    . ASP A 1 103 ? 38.230 -38.819 -21.354 1.00 81.36  ? 21  ASP A CA    1 
ATOM   89   C  C     . ASP A 1 103 ? 38.394 -37.432 -20.726 1.00 76.16  ? 21  ASP A C     1 
ATOM   90   O  O     . ASP A 1 103 ? 37.673 -37.030 -19.804 1.00 58.66  ? 21  ASP A O     1 
ATOM   91   C  CB    . ASP A 1 103 ? 36.769 -39.234 -21.429 1.00 85.62  ? 21  ASP A CB    1 
ATOM   92   C  CG    . ASP A 1 103 ? 35.832 -38.209 -22.064 1.00 87.44  ? 21  ASP A CG    1 
ATOM   93   O  OD1   . ASP A 1 103 ? 36.312 -37.228 -22.699 1.00 78.88  ? 21  ASP A OD1   1 
ATOM   94   O  OD2   . ASP A 1 103 ? 34.616 -38.382 -21.902 1.00 88.42  ? 21  ASP A OD2   1 
ATOM   95   N  N     . TRP A 1 104 ? 39.352 -36.688 -21.278 1.00 78.64  ? 22  TRP A N     1 
ATOM   96   C  CA    . TRP A 1 104 ? 39.803 -35.452 -20.675 1.00 68.79  ? 22  TRP A CA    1 
ATOM   97   C  C     . TRP A 1 104 ? 38.616 -34.500 -20.575 1.00 70.23  ? 22  TRP A C     1 
ATOM   98   O  O     . TRP A 1 104 ? 38.396 -33.926 -19.505 1.00 66.78  ? 22  TRP A O     1 
ATOM   99   C  CB    . TRP A 1 104 ? 40.995 -34.925 -21.483 1.00 67.51  ? 22  TRP A CB    1 
ATOM   100  C  CG    . TRP A 1 104 ? 42.210 -35.829 -21.416 1.00 70.66  ? 22  TRP A CG    1 
ATOM   101  C  CD1   . TRP A 1 104 ? 42.925 -36.344 -22.463 1.00 66.03  ? 22  TRP A CD1   1 
ATOM   102  C  CD2   . TRP A 1 104 ? 42.873 -36.304 -20.217 1.00 68.62  ? 22  TRP A CD2   1 
ATOM   103  N  NE1   . TRP A 1 104 ? 43.977 -37.098 -22.008 1.00 68.39  ? 22  TRP A NE1   1 
ATOM   104  C  CE2   . TRP A 1 104 ? 43.964 -37.100 -20.637 1.00 65.04  ? 22  TRP A CE2   1 
ATOM   105  C  CE3   . TRP A 1 104 ? 42.651 -36.135 -18.839 1.00 69.73  ? 22  TRP A CE3   1 
ATOM   106  C  CZ2   . TRP A 1 104 ? 44.818 -37.720 -19.725 1.00 67.06  ? 22  TRP A CZ2   1 
ATOM   107  C  CZ3   . TRP A 1 104 ? 43.492 -36.759 -17.939 1.00 66.17  ? 22  TRP A CZ3   1 
ATOM   108  C  CH2   . TRP A 1 104 ? 44.564 -37.538 -18.380 1.00 65.27  ? 22  TRP A CH2   1 
ATOM   109  N  N     . ALA A 1 105 ? 37.786 -34.474 -21.635 1.00 64.07  ? 23  ALA A N     1 
ATOM   110  C  CA    . ALA A 1 105 ? 36.654 -33.559 -21.743 1.00 63.18  ? 23  ALA A CA    1 
ATOM   111  C  C     . ALA A 1 105 ? 35.667 -33.691 -20.583 1.00 66.24  ? 23  ALA A C     1 
ATOM   112  O  O     . ALA A 1 105 ? 35.116 -32.687 -20.120 1.00 67.05  ? 23  ALA A O     1 
ATOM   113  C  CB    . ALA A 1 105 ? 35.949 -33.747 -23.059 1.00 59.08  ? 23  ALA A CB    1 
ATOM   114  N  N     . ALA A 1 106 ? 35.416 -34.918 -20.124 1.00 64.90  ? 24  ALA A N     1 
ATOM   115  C  CA    . ALA A 1 106 ? 34.371 -35.113 -19.134 1.00 66.66  ? 24  ALA A CA    1 
ATOM   116  C  C     . ALA A 1 106 ? 34.916 -34.713 -17.770 1.00 69.92  ? 24  ALA A C     1 
ATOM   117  O  O     . ALA A 1 106 ? 34.195 -34.172 -16.924 1.00 67.72  ? 24  ALA A O     1 
ATOM   118  C  CB    . ALA A 1 106 ? 33.885 -36.541 -19.157 1.00 66.07  ? 24  ALA A CB    1 
ATOM   119  N  N     . LEU A 1 107 ? 36.216 -34.976 -17.599 1.00 75.86  ? 25  LEU A N     1 
ATOM   120  C  CA    . LEU A 1 107 ? 36.947 -34.617 -16.392 1.00 74.73  ? 25  LEU A CA    1 
ATOM   121  C  C     . LEU A 1 107 ? 37.011 -33.099 -16.262 1.00 63.41  ? 25  LEU A C     1 
ATOM   122  O  O     . LEU A 1 107 ? 36.731 -32.552 -15.194 1.00 58.25  ? 25  LEU A O     1 
ATOM   123  C  CB    . LEU A 1 107 ? 38.346 -35.226 -16.446 1.00 80.17  ? 25  LEU A CB    1 
ATOM   124  C  CG    . LEU A 1 107 ? 38.419 -36.755 -16.547 1.00 75.15  ? 25  LEU A CG    1 
ATOM   125  C  CD1   . LEU A 1 107 ? 39.866 -37.175 -16.646 1.00 76.94  ? 25  LEU A CD1   1 
ATOM   126  C  CD2   . LEU A 1 107 ? 37.742 -37.458 -15.379 1.00 75.69  ? 25  LEU A CD2   1 
ATOM   127  N  N     . GLN A 1 108 ? 37.355 -32.447 -17.379 1.00 59.32  ? 26  GLN A N     1 
ATOM   128  C  CA    . GLN A 1 108 ? 37.362 -30.997 -17.476 1.00 59.94  ? 26  GLN A CA    1 
ATOM   129  C  C     . GLN A 1 108 ? 35.999 -30.461 -17.074 1.00 58.72  ? 26  GLN A C     1 
ATOM   130  O  O     . GLN A 1 108 ? 35.938 -29.606 -16.184 1.00 58.00  ? 26  GLN A O     1 
ATOM   131  C  CB    . GLN A 1 108 ? 37.786 -30.536 -18.871 1.00 56.12  ? 26  GLN A CB    1 
ATOM   132  C  CG    . GLN A 1 108 ? 39.219 -30.943 -19.215 1.00 47.13  ? 26  GLN A CG    1 
ATOM   133  C  CD    . GLN A 1 108 ? 39.541 -30.799 -20.685 1.00 50.19  ? 26  GLN A CD    1 
ATOM   134  O  OE1   . GLN A 1 108 ? 38.762 -30.220 -21.446 1.00 50.92  ? 26  GLN A OE1   1 
ATOM   135  N  NE2   . GLN A 1 108 ? 40.712 -31.265 -21.103 1.00 49.16  ? 26  GLN A NE2   1 
ATOM   136  N  N     . ALA A 1 109 ? 34.942 -31.015 -17.695 1.00 63.96  ? 27  ALA A N     1 
ATOM   137  C  CA    . ALA A 1 109 ? 33.565 -30.576 -17.469 1.00 65.65  ? 27  ALA A CA    1 
ATOM   138  C  C     . ALA A 1 109 ? 33.196 -30.662 -15.990 1.00 59.85  ? 27  ALA A C     1 
ATOM   139  O  O     . ALA A 1 109 ? 32.562 -29.758 -15.456 1.00 57.88  ? 27  ALA A O     1 
ATOM   140  C  CB    . ALA A 1 109 ? 32.591 -31.384 -18.307 1.00 61.36  ? 27  ALA A CB    1 
ATOM   141  N  N     . ARG A 1 110 ? 33.572 -31.759 -15.333 1.00 65.56  ? 28  ARG A N     1 
ATOM   142  C  CA    . ARG A 1 110 ? 33.211 -31.958 -13.937 1.00 72.91  ? 28  ARG A CA    1 
ATOM   143  C  C     . ARG A 1 110 ? 34.063 -31.056 -13.046 1.00 68.12  ? 28  ARG A C     1 
ATOM   144  O  O     . ARG A 1 110 ? 33.542 -30.492 -12.081 1.00 64.96  ? 28  ARG A O     1 
ATOM   145  C  CB    . ARG A 1 110 ? 33.347 -33.428 -13.517 1.00 86.01  ? 28  ARG A CB    1 
ATOM   146  C  CG    . ARG A 1 110 ? 32.327 -34.353 -14.167 1.00 105.12 ? 28  ARG A CG    1 
ATOM   147  C  CD    . ARG A 1 110 ? 32.590 -35.803 -13.799 1.00 117.33 ? 28  ARG A CD    1 
ATOM   148  N  NE    . ARG A 1 110 ? 31.687 -36.779 -14.426 1.00 130.67 ? 28  ARG A NE    1 
ATOM   149  C  CZ    . ARG A 1 110 ? 30.775 -37.527 -13.797 1.00 145.09 ? 28  ARG A CZ    1 
ATOM   150  N  NH1   . ARG A 1 110 ? 30.421 -37.259 -12.550 1.00 140.13 ? 28  ARG A NH1   1 
ATOM   151  N  NH2   . ARG A 1 110 ? 30.186 -38.529 -14.432 1.00 152.03 ? 28  ARG A NH2   1 
ATOM   152  N  N     . TYR A 1 111 ? 35.365 -30.920 -13.363 1.00 62.60  ? 29  TYR A N     1 
ATOM   153  C  CA    . TYR A 1 111 ? 36.234 -30.055 -12.572 1.00 58.53  ? 29  TYR A CA    1 
ATOM   154  C  C     . TYR A 1 111 ? 35.698 -28.625 -12.683 1.00 56.49  ? 29  TYR A C     1 
ATOM   155  O  O     . TYR A 1 111 ? 35.489 -27.939 -11.674 1.00 53.69  ? 29  TYR A O     1 
ATOM   156  C  CB    . TYR A 1 111 ? 37.728 -30.186 -12.887 1.00 60.14  ? 29  TYR A CB    1 
ATOM   157  C  CG    . TYR A 1 111 ? 38.531 -29.305 -11.939 1.00 70.40  ? 29  TYR A CG    1 
ATOM   158  C  CD1   . TYR A 1 111 ? 38.712 -29.667 -10.610 1.00 69.25  ? 29  TYR A CD1   1 
ATOM   159  C  CD2   . TYR A 1 111 ? 39.042 -28.069 -12.341 1.00 69.85  ? 29  TYR A CD2   1 
ATOM   160  C  CE1   . TYR A 1 111 ? 39.407 -28.854 -9.721  1.00 64.12  ? 29  TYR A CE1   1 
ATOM   161  C  CE2   . TYR A 1 111 ? 39.741 -27.252 -11.464 1.00 60.29  ? 29  TYR A CE2   1 
ATOM   162  C  CZ    . TYR A 1 111 ? 39.922 -27.640 -10.147 1.00 62.60  ? 29  TYR A CZ    1 
ATOM   163  O  OH    . TYR A 1 111 ? 40.576 -26.835 -9.252  1.00 57.33  ? 29  TYR A OH    1 
ATOM   164  N  N     . TYR A 1 112 ? 35.384 -28.222 -13.919 1.00 49.76  ? 30  TYR A N     1 
ATOM   165  C  CA    . TYR A 1 112 ? 34.764 -26.928 -14.187 1.00 53.26  ? 30  TYR A CA    1 
ATOM   166  C  C     . TYR A 1 112 ? 33.582 -26.698 -13.247 1.00 55.84  ? 30  TYR A C     1 
ATOM   167  O  O     . TYR A 1 112 ? 33.532 -25.670 -12.586 1.00 65.67  ? 30  TYR A O     1 
ATOM   168  C  CB    . TYR A 1 112 ? 34.406 -26.879 -15.679 1.00 56.30  ? 30  TYR A CB    1 
ATOM   169  C  CG    . TYR A 1 112 ? 33.753 -25.598 -16.175 1.00 62.29  ? 30  TYR A CG    1 
ATOM   170  C  CD1   . TYR A 1 112 ? 32.482 -25.222 -15.761 1.00 64.73  ? 30  TYR A CD1   1 
ATOM   171  C  CD2   . TYR A 1 112 ? 34.387 -24.798 -17.115 1.00 64.94  ? 30  TYR A CD2   1 
ATOM   172  C  CE1   . TYR A 1 112 ? 31.887 -24.066 -16.234 1.00 69.34  ? 30  TYR A CE1   1 
ATOM   173  C  CE2   . TYR A 1 112 ? 33.800 -23.644 -17.602 1.00 65.40  ? 30  TYR A CE2   1 
ATOM   174  C  CZ    . TYR A 1 112 ? 32.543 -23.276 -17.162 1.00 69.26  ? 30  TYR A CZ    1 
ATOM   175  O  OH    . TYR A 1 112 ? 31.968 -22.138 -17.662 1.00 72.20  ? 30  TYR A OH    1 
ATOM   176  N  N     . GLU A 1 113 ? 32.630 -27.639 -13.210 1.00 67.18  ? 31  GLU A N     1 
ATOM   177  C  CA    . GLU A 1 113 ? 31.374 -27.472 -12.485 1.00 74.09  ? 31  GLU A CA    1 
ATOM   178  C  C     . GLU A 1 113 ? 31.668 -27.254 -11.004 1.00 64.86  ? 31  GLU A C     1 
ATOM   179  O  O     . GLU A 1 113 ? 30.986 -26.476 -10.351 1.00 73.20  ? 31  GLU A O     1 
ATOM   180  C  CB    . GLU A 1 113 ? 30.406 -28.653 -12.648 1.00 82.34  ? 31  GLU A CB    1 
ATOM   181  C  CG    . GLU A 1 113 ? 29.660 -28.706 -13.985 1.00 94.11  ? 31  GLU A CG    1 
ATOM   182  C  CD    . GLU A 1 113 ? 28.899 -30.013 -14.258 1.00 106.32 ? 31  GLU A CD    1 
ATOM   183  O  OE1   . GLU A 1 113 ? 28.227 -30.496 -13.301 1.00 83.51  ? 31  GLU A OE1   1 
ATOM   184  O  OE2   . GLU A 1 113 ? 28.962 -30.553 -15.408 1.00 89.54  ? 31  GLU A OE2   1 
ATOM   185  N  N     . ALA A 1 114 ? 32.686 -27.943 -10.488 1.00 58.93  ? 32  ALA A N     1 
ATOM   186  C  CA    . ALA A 1 114 ? 33.109 -27.784 -9.101  1.00 65.74  ? 32  ALA A CA    1 
ATOM   187  C  C     . ALA A 1 114 ? 33.761 -26.417 -8.873  1.00 65.83  ? 32  ALA A C     1 
ATOM   188  O  O     . ALA A 1 114 ? 33.455 -25.723 -7.905  1.00 64.71  ? 32  ALA A O     1 
ATOM   189  C  CB    . ALA A 1 114 ? 34.067 -28.911 -8.719  1.00 63.18  ? 32  ALA A CB    1 
ATOM   190  N  N     . ALA A 1 115 ? 34.677 -26.046 -9.774  1.00 61.41  ? 33  ALA A N     1 
ATOM   191  C  CA    . ALA A 1 115 ? 35.468 -24.840 -9.608  1.00 62.52  ? 33  ALA A CA    1 
ATOM   192  C  C     . ALA A 1 115 ? 34.565 -23.604 -9.632  1.00 61.52  ? 33  ALA A C     1 
ATOM   193  O  O     . ALA A 1 115 ? 34.559 -22.808 -8.687  1.00 46.37  ? 33  ALA A O     1 
ATOM   194  C  CB    . ALA A 1 115 ? 36.546 -24.788 -10.678 1.00 61.27  ? 33  ALA A CB    1 
ATOM   195  N  N     . VAL A 1 116 ? 33.779 -23.440 -10.704 1.00 55.23  ? 34  VAL A N     1 
ATOM   196  C  CA    . VAL A 1 116 ? 32.961 -22.238 -10.836 1.00 53.41  ? 34  VAL A CA    1 
ATOM   197  C  C     . VAL A 1 116 ? 31.892 -22.196 -9.743  1.00 55.78  ? 34  VAL A C     1 
ATOM   198  O  O     . VAL A 1 116 ? 31.244 -21.170 -9.573  1.00 54.37  ? 34  VAL A O     1 
ATOM   199  C  CB    . VAL A 1 116 ? 32.319 -22.084 -12.228 1.00 59.80  ? 34  VAL A CB    1 
ATOM   200  C  CG1   . VAL A 1 116 ? 33.369 -22.059 -13.341 1.00 60.84  ? 34  VAL A CG1   1 
ATOM   201  C  CG2   . VAL A 1 116 ? 31.283 -23.172 -12.503 1.00 57.10  ? 34  VAL A CG2   1 
ATOM   202  N  N     . ALA A 1 117 ? 31.699 -23.285 -8.990  1.00 57.60  ? 35  ALA A N     1 
ATOM   203  C  CA    . ALA A 1 117 ? 30.680 -23.294 -7.955  1.00 65.57  ? 35  ALA A CA    1 
ATOM   204  C  C     . ALA A 1 117 ? 31.304 -23.061 -6.581  1.00 64.55  ? 35  ALA A C     1 
ATOM   205  O  O     . ALA A 1 117 ? 30.583 -22.942 -5.591  1.00 72.26  ? 35  ALA A O     1 
ATOM   206  C  CB    . ALA A 1 117 ? 29.908 -24.603 -8.006  1.00 71.87  ? 35  ALA A CB    1 
ATOM   207  N  N     . GLY A 1 118 ? 32.637 -23.026 -6.520  1.00 60.83  ? 36  GLY A N     1 
ATOM   208  C  CA    . GLY A 1 118 ? 33.343 -22.747 -5.278  1.00 59.65  ? 36  GLY A CA    1 
ATOM   209  C  C     . GLY A 1 118 ? 33.442 -24.005 -4.420  1.00 66.62  ? 36  GLY A C     1 
ATOM   210  O  O     . GLY A 1 118 ? 33.591 -23.920 -3.202  1.00 66.95  ? 36  GLY A O     1 
ATOM   211  N  N     . ASP A 1 119 ? 33.375 -25.171 -5.078  1.00 63.17  ? 37  ASP A N     1 
ATOM   212  C  CA    . ASP A 1 119 ? 33.254 -26.436 -4.379  1.00 61.88  ? 37  ASP A CA    1 
ATOM   213  C  C     . ASP A 1 119 ? 34.629 -27.084 -4.260  1.00 60.43  ? 37  ASP A C     1 
ATOM   214  O  O     . ASP A 1 119 ? 34.980 -27.981 -5.038  1.00 56.72  ? 37  ASP A O     1 
ATOM   215  C  CB    . ASP A 1 119 ? 32.221 -27.362 -5.007  1.00 63.77  ? 37  ASP A CB    1 
ATOM   216  C  CG    . ASP A 1 119 ? 31.755 -28.492 -4.093  1.00 69.78  ? 37  ASP A CG    1 
ATOM   217  O  OD1   . ASP A 1 119 ? 32.414 -28.743 -3.051  1.00 74.28  ? 37  ASP A OD1   1 
ATOM   218  O  OD2   . ASP A 1 119 ? 30.720 -29.100 -4.408  1.00 74.51  ? 37  ASP A OD2   1 
ATOM   219  N  N     . GLU A 1 120 ? 35.360 -26.644 -3.227  1.00 59.95  ? 38  GLU A N     1 
ATOM   220  C  CA    . GLU A 1 120 ? 36.712 -27.095 -2.949  1.00 69.51  ? 38  GLU A CA    1 
ATOM   221  C  C     . GLU A 1 120 ? 36.743 -28.621 -2.850  1.00 75.88  ? 38  GLU A C     1 
ATOM   222  O  O     . GLU A 1 120 ? 37.601 -29.252 -3.468  1.00 75.49  ? 38  GLU A O     1 
ATOM   223  C  CB    . GLU A 1 120 ? 37.172 -26.328 -1.703  1.00 80.43  ? 38  GLU A CB    1 
ATOM   224  C  CG    . GLU A 1 120 ? 38.575 -26.679 -1.205  1.00 92.37  ? 38  GLU A CG    1 
ATOM   225  C  CD    . GLU A 1 120 ? 38.993 -25.893 0.029   1.00 96.95  ? 38  GLU A CD    1 
ATOM   226  O  OE1   . GLU A 1 120 ? 38.259 -24.971 0.450   1.00 96.60  ? 38  GLU A OE1   1 
ATOM   227  O  OE2   . GLU A 1 120 ? 40.065 -26.218 0.576   1.00 97.82  ? 38  GLU A OE2   1 
ATOM   228  N  N     . LEU A 1 121 ? 35.787 -29.203 -2.100  1.00 82.29  ? 39  LEU A N     1 
ATOM   229  C  CA    . LEU A 1 121 ? 35.816 -30.626 -1.771  1.00 79.58  ? 39  LEU A CA    1 
ATOM   230  C  C     . LEU A 1 121 ? 35.509 -31.442 -3.026  1.00 72.52  ? 39  LEU A C     1 
ATOM   231  O  O     . LEU A 1 121 ? 36.209 -32.402 -3.317  1.00 74.94  ? 39  LEU A O     1 
ATOM   232  C  CB    . LEU A 1 121 ? 34.880 -31.009 -0.619  1.00 88.23  ? 39  LEU A CB    1 
ATOM   233  C  CG    . LEU A 1 121 ? 35.294 -30.604 0.807   1.00 96.64  ? 39  LEU A CG    1 
ATOM   234  C  CD1   . LEU A 1 121 ? 36.596 -31.250 1.295   1.00 92.41  ? 39  LEU A CD1   1 
ATOM   235  C  CD2   . LEU A 1 121 ? 35.368 -29.086 0.952   1.00 98.80  ? 39  LEU A CD2   1 
ATOM   236  N  N     . ALA A 1 122 ? 34.459 -31.069 -3.772  1.00 72.00  ? 40  ALA A N     1 
ATOM   237  C  CA    . ALA A 1 122 ? 34.142 -31.749 -5.023  1.00 64.29  ? 40  ALA A CA    1 
ATOM   238  C  C     . ALA A 1 122 ? 35.354 -31.696 -5.954  1.00 64.71  ? 40  ALA A C     1 
ATOM   239  O  O     . ALA A 1 122 ? 35.657 -32.666 -6.656  1.00 67.59  ? 40  ALA A O     1 
ATOM   240  C  CB    . ALA A 1 122 ? 32.905 -31.130 -5.658  1.00 61.15  ? 40  ALA A CB    1 
ATOM   241  N  N     . GLY A 1 123 ? 36.068 -30.561 -5.907  1.00 62.76  ? 41  GLY A N     1 
ATOM   242  C  CA    . GLY A 1 123 ? 37.242 -30.345 -6.727  1.00 57.77  ? 41  GLY A CA    1 
ATOM   243  C  C     . GLY A 1 123 ? 38.391 -31.269 -6.352  1.00 56.26  ? 41  GLY A C     1 
ATOM   244  O  O     . GLY A 1 123 ? 38.925 -31.957 -7.217  1.00 55.99  ? 41  GLY A O     1 
ATOM   245  N  N     . VAL A 1 124 ? 38.759 -31.287 -5.066  1.00 60.35  ? 42  VAL A N     1 
ATOM   246  C  CA    . VAL A 1 124 ? 39.826 -32.158 -4.598  1.00 66.32  ? 42  VAL A CA    1 
ATOM   247  C  C     . VAL A 1 124 ? 39.442 -33.622 -4.839  1.00 61.98  ? 42  VAL A C     1 
ATOM   248  O  O     . VAL A 1 124 ? 40.255 -34.400 -5.345  1.00 65.95  ? 42  VAL A O     1 
ATOM   249  C  CB    . VAL A 1 124 ? 40.214 -31.889 -3.127  1.00 79.22  ? 42  VAL A CB    1 
ATOM   250  C  CG1   . VAL A 1 124 ? 39.171 -32.368 -2.122  1.00 96.89  ? 42  VAL A CG1   1 
ATOM   251  C  CG2   . VAL A 1 124 ? 41.563 -32.501 -2.783  1.00 85.01  ? 42  VAL A CG2   1 
ATOM   252  N  N     . ALA A 1 125 ? 38.198 -33.992 -4.502  1.00 67.34  ? 43  ALA A N     1 
ATOM   253  C  CA    . ALA A 1 125 ? 37.728 -35.365 -4.670  1.00 74.52  ? 43  ALA A CA    1 
ATOM   254  C  C     . ALA A 1 125 ? 38.005 -35.819 -6.104  1.00 73.81  ? 43  ALA A C     1 
ATOM   255  O  O     . ALA A 1 125 ? 38.621 -36.857 -6.314  1.00 68.19  ? 43  ALA A O     1 
ATOM   256  C  CB    . ALA A 1 125 ? 36.245 -35.506 -4.307  1.00 64.46  ? 43  ALA A CB    1 
ATOM   257  N  N     . LEU A 1 126 ? 37.576 -35.022 -7.093  1.00 74.15  ? 44  LEU A N     1 
ATOM   258  C  CA    . LEU A 1 126 ? 37.752 -35.408 -8.482  1.00 74.25  ? 44  LEU A CA    1 
ATOM   259  C  C     . LEU A 1 126 ? 39.234 -35.675 -8.734  1.00 71.18  ? 44  LEU A C     1 
ATOM   260  O  O     . LEU A 1 126 ? 39.578 -36.709 -9.297  1.00 72.00  ? 44  LEU A O     1 
ATOM   261  C  CB    . LEU A 1 126 ? 37.166 -34.356 -9.424  1.00 83.42  ? 44  LEU A CB    1 
ATOM   262  C  CG    . LEU A 1 126 ? 37.128 -34.723 -10.915 1.00 87.57  ? 44  LEU A CG    1 
ATOM   263  C  CD1   . LEU A 1 126 ? 36.178 -33.808 -11.651 1.00 94.36  ? 44  LEU A CD1   1 
ATOM   264  C  CD2   . LEU A 1 126 ? 38.485 -34.648 -11.594 1.00 87.61  ? 44  LEU A CD2   1 
ATOM   265  N  N     . LEU A 1 127 ? 40.118 -34.781 -8.261  1.00 75.57  ? 45  LEU A N     1 
ATOM   266  C  CA    . LEU A 1 127 ? 41.557 -34.938 -8.468  1.00 73.36  ? 45  LEU A CA    1 
ATOM   267  C  C     . LEU A 1 127 ? 42.067 -36.175 -7.732  1.00 74.17  ? 45  LEU A C     1 
ATOM   268  O  O     . LEU A 1 127 ? 42.720 -37.004 -8.367  1.00 63.91  ? 45  LEU A O     1 
ATOM   269  C  CB    . LEU A 1 127 ? 42.372 -33.709 -8.057  1.00 70.50  ? 45  LEU A CB    1 
ATOM   270  C  CG    . LEU A 1 127 ? 42.143 -32.442 -8.884  1.00 68.64  ? 45  LEU A CG    1 
ATOM   271  C  CD1   . LEU A 1 127 ? 42.819 -31.244 -8.232  1.00 70.05  ? 45  LEU A CD1   1 
ATOM   272  C  CD2   . LEU A 1 127 ? 42.624 -32.624 -10.316 1.00 62.89  ? 45  LEU A CD2   1 
ATOM   273  N  N     . GLU A 1 128 ? 41.800 -36.256 -6.408  1.00 73.92  ? 46  GLU A N     1 
ATOM   274  C  CA    . GLU A 1 128 ? 42.217 -37.379 -5.565  1.00 79.05  ? 46  GLU A CA    1 
ATOM   275  C  C     . GLU A 1 128 ? 41.895 -38.705 -6.279  1.00 78.11  ? 46  GLU A C     1 
ATOM   276  O  O     . GLU A 1 128 ? 42.772 -39.536 -6.523  1.00 75.05  ? 46  GLU A O     1 
ATOM   277  C  CB    . GLU A 1 128 ? 41.621 -37.238 -4.151  1.00 77.64  ? 46  GLU A CB    1 
ATOM   278  C  CG    . GLU A 1 128 ? 42.403 -36.323 -3.202  1.00 79.83  ? 46  GLU A CG    1 
ATOM   279  C  CD    . GLU A 1 128 ? 41.807 -35.942 -1.839  1.00 92.01  ? 46  GLU A CD    1 
ATOM   280  O  OE1   . GLU A 1 128 ? 40.676 -36.383 -1.540  1.00 83.52  ? 46  GLU A OE1   1 
ATOM   281  O  OE2   . GLU A 1 128 ? 42.462 -35.183 -1.058  1.00 90.48  ? 46  GLU A OE2   1 
ATOM   282  N  N     . ARG A 1 129 ? 40.640 -38.860 -6.708  1.00 80.25  ? 47  ARG A N     1 
ATOM   283  C  CA    . ARG A 1 129 ? 40.164 -40.104 -7.291  1.00 84.27  ? 47  ARG A CA    1 
ATOM   284  C  C     . ARG A 1 129 ? 40.909 -40.427 -8.592  1.00 78.37  ? 47  ARG A C     1 
ATOM   285  O  O     . ARG A 1 129 ? 41.294 -41.570 -8.808  1.00 84.92  ? 47  ARG A O     1 
ATOM   286  C  CB    . ARG A 1 129 ? 38.637 -39.971 -7.363  1.00 95.26  ? 47  ARG A CB    1 
ATOM   287  C  CG    . ARG A 1 129 ? 37.857 -41.263 -7.559  1.00 112.89 ? 47  ARG A CG    1 
ATOM   288  C  CD    . ARG A 1 129 ? 36.385 -41.102 -7.177  1.00 109.95 ? 47  ARG A CD    1 
ATOM   289  N  NE    . ARG A 1 129 ? 35.607 -42.205 -7.751  1.00 116.25 ? 47  ARG A NE    1 
ATOM   290  C  CZ    . ARG A 1 129 ? 35.709 -43.482 -7.411  1.00 106.99 ? 47  ARG A CZ    1 
ATOM   291  N  NH1   . ARG A 1 129 ? 36.369 -43.833 -6.323  1.00 107.71 ? 47  ARG A NH1   1 
ATOM   292  N  NH2   . ARG A 1 129 ? 35.117 -44.403 -8.148  1.00 103.58 ? 47  ARG A NH2   1 
ATOM   293  N  N     . ALA A 1 130 ? 41.165 -39.425 -9.440  1.00 71.93  ? 48  ALA A N     1 
ATOM   294  C  CA    . ALA A 1 130 ? 41.891 -39.642 -10.686 1.00 68.88  ? 48  ALA A CA    1 
ATOM   295  C  C     . ALA A 1 130 ? 43.360 -40.029 -10.465 1.00 72.64  ? 48  ALA A C     1 
ATOM   296  O  O     . ALA A 1 130 ? 43.969 -40.642 -11.339 1.00 71.55  ? 48  ALA A O     1 
ATOM   297  C  CB    . ALA A 1 130 ? 41.792 -38.396 -11.526 1.00 69.47  ? 48  ALA A CB    1 
ATOM   298  N  N     . TYR A 1 131 ? 43.957 -39.655 -9.322  1.00 77.51  ? 49  TYR A N     1 
ATOM   299  C  CA    . TYR A 1 131 ? 45.339 -40.021 -9.023  1.00 81.45  ? 49  TYR A CA    1 
ATOM   300  C  C     . TYR A 1 131 ? 45.391 -41.511 -8.686  1.00 86.49  ? 49  TYR A C     1 
ATOM   301  O  O     . TYR A 1 131 ? 46.189 -42.251 -9.267  1.00 85.48  ? 49  TYR A O     1 
ATOM   302  C  CB    . TYR A 1 131 ? 45.938 -39.193 -7.876  1.00 74.47  ? 49  TYR A CB    1 
ATOM   303  C  CG    . TYR A 1 131 ? 47.324 -39.614 -7.387  1.00 72.87  ? 49  TYR A CG    1 
ATOM   304  C  CD1   . TYR A 1 131 ? 48.380 -39.774 -8.281  1.00 69.58  ? 49  TYR A CD1   1 
ATOM   305  C  CD2   . TYR A 1 131 ? 47.571 -39.878 -6.034  1.00 69.23  ? 49  TYR A CD2   1 
ATOM   306  C  CE1   . TYR A 1 131 ? 49.638 -40.166 -7.849  1.00 69.04  ? 49  TYR A CE1   1 
ATOM   307  C  CE2   . TYR A 1 131 ? 48.828 -40.276 -5.584  1.00 69.32  ? 49  TYR A CE2   1 
ATOM   308  C  CZ    . TYR A 1 131 ? 49.867 -40.420 -6.500  1.00 76.81  ? 49  TYR A CZ    1 
ATOM   309  O  OH    . TYR A 1 131 ? 51.136 -40.802 -6.120  1.00 66.96  ? 49  TYR A OH    1 
ATOM   310  N  N     . ARG A 1 132 ? 44.515 -41.923 -7.754  1.00 92.71  ? 50  ARG A N     1 
ATOM   311  C  CA    . ARG A 1 132 ? 44.444 -43.292 -7.262  1.00 89.03  ? 50  ARG A CA    1 
ATOM   312  C  C     . ARG A 1 132 ? 43.905 -44.236 -8.325  1.00 79.64  ? 50  ARG A C     1 
ATOM   313  O  O     . ARG A 1 132 ? 44.070 -45.438 -8.190  1.00 78.71  ? 50  ARG A O     1 
ATOM   314  C  CB    . ARG A 1 132 ? 43.552 -43.437 -6.027  1.00 96.41  ? 50  ARG A CB    1 
ATOM   315  C  CG    . ARG A 1 132 ? 44.323 -43.180 -4.741  1.00 111.54 ? 50  ARG A CG    1 
ATOM   316  C  CD    . ARG A 1 132 ? 43.400 -43.165 -3.545  1.00 125.41 ? 50  ARG A CD    1 
ATOM   317  N  NE    . ARG A 1 132 ? 42.301 -42.227 -3.810  1.00 116.56 ? 50  ARG A NE    1 
ATOM   318  C  CZ    . ARG A 1 132 ? 41.048 -42.366 -3.411  1.00 104.86 ? 50  ARG A CZ    1 
ATOM   319  N  NH1   . ARG A 1 132 ? 40.714 -43.349 -2.583  1.00 117.02 ? 50  ARG A NH1   1 
ATOM   320  N  NH2   . ARG A 1 132 ? 40.147 -41.475 -3.784  1.00 86.69  ? 50  ARG A NH2   1 
ATOM   321  N  N     . SER A 1 133 ? 43.395 -43.651 -9.411  1.00 82.93  ? 51  SER A N     1 
ATOM   322  C  CA    . SER A 1 133 ? 42.981 -44.455 -10.583 1.00 83.07  ? 51  SER A CA    1 
ATOM   323  C  C     . SER A 1 133 ? 44.219 -44.615 -11.464 1.00 78.45  ? 51  SER A C     1 
ATOM   324  O  O     . SER A 1 133 ? 44.110 -45.249 -12.524 1.00 73.90  ? 51  SER A O     1 
ATOM   325  C  CB    . SER A 1 133 ? 41.896 -43.773 -11.335 1.00 82.92  ? 51  SER A CB    1 
ATOM   326  O  OG    . SER A 1 133 ? 42.397 -43.180 -12.524 1.00 90.28  ? 51  SER A OG    1 
ATOM   327  N  N     . GLY A 1 134 ? 45.336 -44.019 -11.046 1.00 76.74  ? 52  GLY A N     1 
ATOM   328  C  CA    . GLY A 1 134 ? 46.588 -44.143 -11.777 1.00 74.05  ? 52  GLY A CA    1 
ATOM   329  C  C     . GLY A 1 134 ? 46.854 -43.021 -12.792 1.00 76.89  ? 52  GLY A C     1 
ATOM   330  O  O     . GLY A 1 134 ? 47.813 -43.113 -13.548 1.00 66.86  ? 52  GLY A O     1 
ATOM   331  N  N     . ILE A 1 135 ? 46.058 -41.940 -12.825 1.00 86.55  ? 53  ILE A N     1 
ATOM   332  C  CA    . ILE A 1 135 ? 46.416 -40.808 -13.678 1.00 75.14  ? 53  ILE A CA    1 
ATOM   333  C  C     . ILE A 1 135 ? 47.483 -39.990 -12.955 1.00 64.71  ? 53  ILE A C     1 
ATOM   334  O  O     . ILE A 1 135 ? 47.310 -39.606 -11.790 1.00 59.80  ? 53  ILE A O     1 
ATOM   335  C  CB    . ILE A 1 135 ? 45.229 -39.908 -14.078 1.00 76.46  ? 53  ILE A CB    1 
ATOM   336  C  CG1   . ILE A 1 135 ? 44.049 -40.711 -14.624 1.00 77.34  ? 53  ILE A CG1   1 
ATOM   337  C  CG2   . ILE A 1 135 ? 45.687 -38.839 -15.077 1.00 74.34  ? 53  ILE A CG2   1 
ATOM   338  C  CD1   . ILE A 1 135 ? 42.813 -39.888 -14.946 1.00 77.77  ? 53  ILE A CD1   1 
ATOM   339  N  N     . PRO A 1 136 ? 48.621 -39.709 -13.624 1.00 57.33  ? 54  PRO A N     1 
ATOM   340  C  CA    . PRO A 1 136 ? 49.687 -38.906 -12.999 1.00 58.39  ? 54  PRO A CA    1 
ATOM   341  C  C     . PRO A 1 136 ? 49.312 -37.424 -12.798 1.00 57.86  ? 54  PRO A C     1 
ATOM   342  O  O     . PRO A 1 136 ? 48.573 -36.814 -13.593 1.00 50.92  ? 54  PRO A O     1 
ATOM   343  C  CB    . PRO A 1 136 ? 50.900 -39.107 -13.956 1.00 54.60  ? 54  PRO A CB    1 
ATOM   344  C  CG    . PRO A 1 136 ? 50.455 -40.185 -14.978 1.00 54.50  ? 54  PRO A CG    1 
ATOM   345  C  CD    . PRO A 1 136 ? 48.933 -40.147 -15.001 1.00 55.75  ? 54  PRO A CD    1 
ATOM   346  N  N     . VAL A 1 137 ? 49.836 -36.833 -11.718 1.00 55.47  ? 55  VAL A N     1 
ATOM   347  C  CA    . VAL A 1 137 ? 49.504 -35.465 -11.335 1.00 56.12  ? 55  VAL A CA    1 
ATOM   348  C  C     . VAL A 1 137 ? 49.792 -34.499 -12.489 1.00 48.20  ? 55  VAL A C     1 
ATOM   349  O  O     . VAL A 1 137 ? 48.984 -33.622 -12.795 1.00 49.00  ? 55  VAL A O     1 
ATOM   350  C  CB    . VAL A 1 137 ? 50.224 -35.029 -10.038 1.00 59.05  ? 55  VAL A CB    1 
ATOM   351  C  CG1   . VAL A 1 137 ? 49.933 -33.573 -9.680  1.00 61.45  ? 55  VAL A CG1   1 
ATOM   352  C  CG2   . VAL A 1 137 ? 49.815 -35.916 -8.866  1.00 67.11  ? 55  VAL A CG2   1 
ATOM   353  N  N     . VAL A 1 138 ? 50.947 -34.649 -13.123 1.00 42.44  ? 56  VAL A N     1 
ATOM   354  C  CA    . VAL A 1 138 ? 51.316 -33.791 -14.229 1.00 44.53  ? 56  VAL A CA    1 
ATOM   355  C  C     . VAL A 1 138 ? 50.260 -33.819 -15.331 1.00 47.85  ? 56  VAL A C     1 
ATOM   356  O  O     . VAL A 1 138 ? 50.012 -32.797 -15.963 1.00 56.00  ? 56  VAL A O     1 
ATOM   357  C  CB    . VAL A 1 138 ? 52.687 -34.187 -14.787 1.00 44.90  ? 56  VAL A CB    1 
ATOM   358  C  CG1   . VAL A 1 138 ? 52.936 -33.535 -16.138 1.00 51.44  ? 56  VAL A CG1   1 
ATOM   359  C  CG2   . VAL A 1 138 ? 53.801 -33.847 -13.809 1.00 45.37  ? 56  VAL A CG2   1 
ATOM   360  N  N     . ALA A 1 139 ? 49.655 -34.980 -15.596 1.00 55.79  ? 57  ALA A N     1 
ATOM   361  C  CA    . ALA A 1 139 ? 48.687 -35.091 -16.683 1.00 53.46  ? 57  ALA A CA    1 
ATOM   362  C  C     . ALA A 1 139 ? 47.337 -34.522 -16.252 1.00 50.88  ? 57  ALA A C     1 
ATOM   363  O  O     . ALA A 1 139 ? 46.638 -33.900 -17.042 1.00 51.42  ? 57  ALA A O     1 
ATOM   364  C  CB    . ALA A 1 139 ? 48.591 -36.524 -17.143 1.00 58.21  ? 57  ALA A CB    1 
ATOM   365  N  N     . LEU A 1 140 ? 46.980 -34.693 -14.977 1.00 56.18  ? 58  LEU A N     1 
ATOM   366  C  CA    . LEU A 1 140 ? 45.860 -33.949 -14.420 1.00 53.98  ? 58  LEU A CA    1 
ATOM   367  C  C     . LEU A 1 140 ? 46.054 -32.460 -14.675 1.00 55.88  ? 58  LEU A C     1 
ATOM   368  O  O     . LEU A 1 140 ? 45.122 -31.806 -15.130 1.00 53.34  ? 58  LEU A O     1 
ATOM   369  C  CB    . LEU A 1 140 ? 45.689 -34.219 -12.928 1.00 50.62  ? 58  LEU A CB    1 
ATOM   370  C  CG    . LEU A 1 140 ? 45.303 -35.661 -12.609 1.00 62.08  ? 58  LEU A CG    1 
ATOM   371  C  CD1   . LEU A 1 140 ? 45.061 -35.870 -11.124 1.00 66.89  ? 58  LEU A CD1   1 
ATOM   372  C  CD2   . LEU A 1 140 ? 44.083 -36.046 -13.437 1.00 58.94  ? 58  LEU A CD2   1 
ATOM   373  N  N     . LYS A 1 141 ? 47.261 -31.960 -14.355 1.00 52.74  ? 59  LYS A N     1 
ATOM   374  C  CA    . LYS A 1 141 ? 47.595 -30.548 -14.429 1.00 51.94  ? 59  LYS A CA    1 
ATOM   375  C  C     . LYS A 1 141 ? 47.549 -30.022 -15.866 1.00 49.68  ? 59  LYS A C     1 
ATOM   376  O  O     . LYS A 1 141 ? 47.029 -28.935 -16.105 1.00 49.60  ? 59  LYS A O     1 
ATOM   377  C  CB    . LYS A 1 141 ? 48.987 -30.337 -13.822 1.00 50.96  ? 59  LYS A CB    1 
ATOM   378  C  CG    . LYS A 1 141 ? 48.994 -30.327 -12.303 1.00 50.81  ? 59  LYS A CG    1 
ATOM   379  C  CD    . LYS A 1 141 ? 50.399 -30.253 -11.720 1.00 48.59  ? 59  LYS A CD    1 
ATOM   380  C  CE    . LYS A 1 141 ? 50.339 -30.007 -10.248 1.00 50.41  ? 59  LYS A CE    1 
ATOM   381  N  NZ    . LYS A 1 141 ? 51.653 -29.840 -9.623  1.00 51.13  ? 59  LYS A NZ    1 
ATOM   382  N  N     . GLU A 1 142 ? 48.088 -30.796 -16.810 1.00 48.72  ? 60  GLU A N     1 
ATOM   383  C  CA    . GLU A 1 142 ? 48.208 -30.361 -18.189 1.00 53.33  ? 60  GLU A CA    1 
ATOM   384  C  C     . GLU A 1 142 ? 46.908 -30.572 -18.963 1.00 53.02  ? 60  GLU A C     1 
ATOM   385  O  O     . GLU A 1 142 ? 46.645 -29.822 -19.900 1.00 54.06  ? 60  GLU A O     1 
ATOM   386  C  CB    . GLU A 1 142 ? 49.413 -31.035 -18.832 1.00 52.36  ? 60  GLU A CB    1 
ATOM   387  C  CG    . GLU A 1 142 ? 50.712 -30.315 -18.471 1.00 58.87  ? 60  GLU A CG    1 
ATOM   388  C  CD    . GLU A 1 142 ? 51.929 -30.806 -19.232 1.00 68.17  ? 60  GLU A CD    1 
ATOM   389  O  OE1   . GLU A 1 142 ? 52.159 -32.048 -19.235 1.00 70.62  ? 60  GLU A OE1   1 
ATOM   390  O  OE2   . GLU A 1 142 ? 52.640 -29.957 -19.821 1.00 68.88  ? 60  GLU A OE2   1 
ATOM   391  N  N     . HIS A 1 143 ? 46.077 -31.535 -18.542 1.00 47.78  ? 61  HIS A N     1 
ATOM   392  C  CA    . HIS A 1 143 ? 44.980 -31.990 -19.387 1.00 49.24  ? 61  HIS A CA    1 
ATOM   393  C  C     . HIS A 1 143 ? 43.619 -31.904 -18.692 1.00 52.37  ? 61  HIS A C     1 
ATOM   394  O  O     . HIS A 1 143 ? 42.618 -32.127 -19.356 1.00 53.30  ? 61  HIS A O     1 
ATOM   395  C  CB    . HIS A 1 143 ? 45.263 -33.378 -19.972 1.00 48.03  ? 61  HIS A CB    1 
ATOM   396  C  CG    . HIS A 1 143 ? 46.523 -33.511 -20.771 1.00 51.34  ? 61  HIS A CG    1 
ATOM   397  N  ND1   . HIS A 1 143 ? 46.880 -32.672 -21.810 1.00 65.38  ? 61  HIS A ND1   1 
ATOM   398  C  CD2   . HIS A 1 143 ? 47.487 -34.439 -20.701 1.00 51.80  ? 61  HIS A CD2   1 
ATOM   399  C  CE1   . HIS A 1 143 ? 48.044 -33.067 -22.326 1.00 63.67  ? 61  HIS A CE1   1 
ATOM   400  N  NE2   . HIS A 1 143 ? 48.425 -34.151 -21.675 1.00 58.34  ? 61  HIS A NE2   1 
ATOM   401  N  N     . VAL A 1 144 ? 43.557 -31.485 -17.415 1.00 54.12  ? 62  VAL A N     1 
ATOM   402  C  CA    . VAL A 1 144 ? 42.294 -31.137 -16.767 1.00 52.22  ? 62  VAL A CA    1 
ATOM   403  C  C     . VAL A 1 144 ? 42.347 -29.662 -16.331 1.00 56.25  ? 62  VAL A C     1 
ATOM   404  O  O     . VAL A 1 144 ? 41.536 -28.829 -16.755 1.00 53.04  ? 62  VAL A O     1 
ATOM   405  C  CB    . VAL A 1 144 ? 41.942 -32.079 -15.582 1.00 56.14  ? 62  VAL A CB    1 
ATOM   406  C  CG1   . VAL A 1 144 ? 40.579 -31.803 -14.951 1.00 54.72  ? 62  VAL A CG1   1 
ATOM   407  C  CG2   . VAL A 1 144 ? 41.989 -33.544 -15.969 1.00 59.31  ? 62  VAL A CG2   1 
ATOM   408  N  N     . LEU A 1 145 ? 43.295 -29.326 -15.447 1.00 60.40  ? 63  LEU A N     1 
ATOM   409  C  CA    . LEU A 1 145 ? 43.303 -28.023 -14.801 1.00 51.16  ? 63  LEU A CA    1 
ATOM   410  C  C     . LEU A 1 145 ? 43.599 -26.917 -15.805 1.00 44.87  ? 63  LEU A C     1 
ATOM   411  O  O     . LEU A 1 145 ? 42.860 -25.953 -15.886 1.00 50.27  ? 63  LEU A O     1 
ATOM   412  C  CB    . LEU A 1 145 ? 44.330 -28.064 -13.683 1.00 54.34  ? 63  LEU A CB    1 
ATOM   413  C  CG    . LEU A 1 145 ? 43.987 -28.985 -12.509 1.00 56.79  ? 63  LEU A CG    1 
ATOM   414  C  CD1   . LEU A 1 145 ? 45.134 -28.901 -11.521 1.00 59.53  ? 63  LEU A CD1   1 
ATOM   415  C  CD2   . LEU A 1 145 ? 42.682 -28.608 -11.833 1.00 55.04  ? 63  LEU A CD2   1 
ATOM   416  N  N     . THR A 1 146 ? 44.663 -27.060 -16.587 1.00 43.62  ? 64  THR A N     1 
ATOM   417  C  CA    . THR A 1 146 ? 45.063 -25.997 -17.489 1.00 45.64  ? 64  THR A CA    1 
ATOM   418  C  C     . THR A 1 146 ? 43.964 -25.736 -18.530 1.00 49.26  ? 64  THR A C     1 
ATOM   419  O  O     . THR A 1 146 ? 43.472 -24.621 -18.639 1.00 53.79  ? 64  THR A O     1 
ATOM   420  C  CB    . THR A 1 146 ? 46.433 -26.334 -18.079 1.00 45.50  ? 64  THR A CB    1 
ATOM   421  O  OG1   . THR A 1 146 ? 47.320 -26.429 -16.978 1.00 44.14  ? 64  THR A OG1   1 
ATOM   422  C  CG2   . THR A 1 146 ? 47.034 -25.219 -18.909 1.00 48.02  ? 64  THR A CG2   1 
ATOM   423  N  N     . PRO A 1 147 ? 43.490 -26.725 -19.315 1.00 62.91  ? 65  PRO A N     1 
ATOM   424  C  CA    . PRO A 1 147 ? 42.392 -26.476 -20.262 1.00 57.28  ? 65  PRO A CA    1 
ATOM   425  C  C     . PRO A 1 147 ? 41.145 -25.806 -19.680 1.00 51.39  ? 65  PRO A C     1 
ATOM   426  O  O     . PRO A 1 147 ? 40.519 -24.955 -20.318 1.00 49.49  ? 65  PRO A O     1 
ATOM   427  C  CB    . PRO A 1 147 ? 42.082 -27.914 -20.718 1.00 58.92  ? 65  PRO A CB    1 
ATOM   428  C  CG    . PRO A 1 147 ? 43.422 -28.608 -20.665 1.00 61.92  ? 65  PRO A CG    1 
ATOM   429  C  CD    . PRO A 1 147 ? 43.971 -28.122 -19.333 1.00 66.13  ? 65  PRO A CD    1 
ATOM   430  N  N     . VAL A 1 148 ? 40.777 -26.210 -18.459 1.00 44.27  ? 66  VAL A N     1 
ATOM   431  C  CA    . VAL A 1 148 ? 39.604 -25.658 -17.804 1.00 47.62  ? 66  VAL A CA    1 
ATOM   432  C  C     . VAL A 1 148 ? 39.788 -24.160 -17.572 1.00 51.62  ? 66  VAL A C     1 
ATOM   433  O  O     . VAL A 1 148 ? 38.887 -23.353 -17.836 1.00 52.29  ? 66  VAL A O     1 
ATOM   434  C  CB    . VAL A 1 148 ? 39.293 -26.413 -16.500 1.00 47.29  ? 66  VAL A CB    1 
ATOM   435  C  CG1   . VAL A 1 148 ? 38.411 -25.608 -15.566 1.00 47.99  ? 66  VAL A CG1   1 
ATOM   436  C  CG2   . VAL A 1 148 ? 38.632 -27.748 -16.787 1.00 53.27  ? 66  VAL A CG2   1 
ATOM   437  N  N     . LEU A 1 149 ? 40.965 -23.790 -17.071 1.00 47.72  ? 67  LEU A N     1 
ATOM   438  C  CA    . LEU A 1 149 ? 41.216 -22.398 -16.747 1.00 50.85  ? 67  LEU A CA    1 
ATOM   439  C  C     . LEU A 1 149 ? 41.301 -21.572 -18.028 1.00 51.00  ? 67  LEU A C     1 
ATOM   440  O  O     . LEU A 1 149 ? 40.857 -20.429 -18.060 1.00 51.80  ? 67  LEU A O     1 
ATOM   441  C  CB    . LEU A 1 149 ? 42.488 -22.334 -15.909 1.00 49.38  ? 67  LEU A CB    1 
ATOM   442  C  CG    . LEU A 1 149 ? 42.287 -22.743 -14.456 1.00 45.27  ? 67  LEU A CG    1 
ATOM   443  C  CD1   . LEU A 1 149 ? 43.596 -23.032 -13.779 1.00 43.85  ? 67  LEU A CD1   1 
ATOM   444  C  CD2   . LEU A 1 149 ? 41.525 -21.632 -13.797 1.00 44.48  ? 67  LEU A CD2   1 
ATOM   445  N  N     . HIS A 1 150 ? 41.865 -22.154 -19.088 1.00 47.16  ? 68  HIS A N     1 
ATOM   446  C  CA    . HIS A 1 150 ? 41.921 -21.450 -20.356 1.00 51.42  ? 68  HIS A CA    1 
ATOM   447  C  C     . HIS A 1 150 ? 40.481 -21.167 -20.774 1.00 53.45  ? 68  HIS A C     1 
ATOM   448  O  O     . HIS A 1 150 ? 40.158 -20.061 -21.185 1.00 59.32  ? 68  HIS A O     1 
ATOM   449  C  CB    . HIS A 1 150 ? 42.747 -22.220 -21.399 1.00 50.22  ? 68  HIS A CB    1 
ATOM   450  C  CG    . HIS A 1 150 ? 44.225 -22.186 -21.201 1.00 51.44  ? 68  HIS A CG    1 
ATOM   451  N  ND1   . HIS A 1 150 ? 45.111 -22.738 -22.098 1.00 59.30  ? 68  HIS A ND1   1 
ATOM   452  C  CD2   . HIS A 1 150 ? 44.966 -21.729 -20.192 1.00 57.74  ? 68  HIS A CD2   1 
ATOM   453  C  CE1   . HIS A 1 150 ? 46.350 -22.563 -21.659 1.00 60.41  ? 68  HIS A CE1   1 
ATOM   454  N  NE2   . HIS A 1 150 ? 46.282 -21.963 -20.492 1.00 57.52  ? 68  HIS A NE2   1 
ATOM   455  N  N     . LEU A 1 151 ? 39.603 -22.164 -20.625 1.00 54.57  ? 69  LEU A N     1 
ATOM   456  C  CA    . LEU A 1 151 ? 38.245 -22.028 -21.108 1.00 50.53  ? 69  LEU A CA    1 
ATOM   457  C  C     . LEU A 1 151 ? 37.478 -21.005 -20.262 1.00 53.58  ? 69  LEU A C     1 
ATOM   458  O  O     . LEU A 1 151 ? 36.719 -20.188 -20.798 1.00 49.11  ? 69  LEU A O     1 
ATOM   459  C  CB    . LEU A 1 151 ? 37.585 -23.402 -21.091 1.00 59.33  ? 69  LEU A CB    1 
ATOM   460  C  CG    . LEU A 1 151 ? 36.099 -23.402 -21.481 1.00 69.23  ? 69  LEU A CG    1 
ATOM   461  C  CD1   . LEU A 1 151 ? 35.939 -23.104 -22.981 1.00 60.37  ? 69  LEU A CD1   1 
ATOM   462  C  CD2   . LEU A 1 151 ? 35.413 -24.700 -21.049 1.00 66.70  ? 69  LEU A CD2   1 
ATOM   463  N  N     . ILE A 1 152 ? 37.642 -21.081 -18.930 1.00 46.74  ? 70  ILE A N     1 
ATOM   464  C  CA    . ILE A 1 152 ? 37.103 -20.056 -18.056 1.00 49.02  ? 70  ILE A CA    1 
ATOM   465  C  C     . ILE A 1 152 ? 37.437 -18.662 -18.601 1.00 50.00  ? 70  ILE A C     1 
ATOM   466  O  O     . ILE A 1 152 ? 36.588 -17.777 -18.609 1.00 48.58  ? 70  ILE A O     1 
ATOM   467  C  CB    . ILE A 1 152 ? 37.621 -20.255 -16.623 1.00 48.94  ? 70  ILE A CB    1 
ATOM   468  C  CG1   . ILE A 1 152 ? 37.012 -21.523 -16.023 1.00 52.67  ? 70  ILE A CG1   1 
ATOM   469  C  CG2   . ILE A 1 152 ? 37.360 -19.015 -15.757 1.00 42.07  ? 70  ILE A CG2   1 
ATOM   470  C  CD1   . ILE A 1 152 ? 37.264 -21.696 -14.533 1.00 53.27  ? 70  ILE A CD1   1 
ATOM   471  N  N     . GLY A 1 153 ? 38.692 -18.446 -19.002 1.00 47.21  ? 71  GLY A N     1 
ATOM   472  C  CA    . GLY A 1 153 ? 39.093 -17.160 -19.539 1.00 49.52  ? 71  GLY A CA    1 
ATOM   473  C  C     . GLY A 1 153 ? 38.448 -16.873 -20.897 1.00 51.08  ? 71  GLY A C     1 
ATOM   474  O  O     . GLY A 1 153 ? 38.046 -15.745 -21.144 1.00 53.57  ? 71  GLY A O     1 
ATOM   475  N  N     . GLU A 1 154 ? 38.377 -17.868 -21.796 1.00 55.66  ? 72  GLU A N     1 
ATOM   476  C  CA    . GLU A 1 154 ? 37.761 -17.657 -23.103 1.00 55.74  ? 72  GLU A CA    1 
ATOM   477  C  C     . GLU A 1 154 ? 36.299 -17.268 -22.891 1.00 55.09  ? 72  GLU A C     1 
ATOM   478  O  O     . GLU A 1 154 ? 35.807 -16.336 -23.518 1.00 59.00  ? 72  GLU A O     1 
ATOM   479  C  CB    . GLU A 1 154 ? 37.829 -18.838 -24.074 1.00 58.46  ? 72  GLU A CB    1 
ATOM   480  C  CG    . GLU A 1 154 ? 39.236 -19.253 -24.514 1.00 72.05  ? 72  GLU A CG    1 
ATOM   481  C  CD    . GLU A 1 154 ? 40.158 -18.213 -25.170 1.00 88.96  ? 72  GLU A CD    1 
ATOM   482  O  OE1   . GLU A 1 154 ? 39.653 -17.359 -25.942 1.00 90.02  ? 72  GLU A OE1   1 
ATOM   483  O  OE2   . GLU A 1 154 ? 41.404 -18.263 -24.940 1.00 79.43  ? 72  GLU A OE2   1 
ATOM   484  N  N     . ARG A 1 155 ? 35.621 -17.947 -21.962 1.00 57.91  ? 73  ARG A N     1 
ATOM   485  C  CA    . ARG A 1 155 ? 34.211 -17.686 -21.701 1.00 65.79  ? 73  ARG A CA    1 
ATOM   486  C  C     . ARG A 1 155 ? 34.021 -16.301 -21.077 1.00 61.85  ? 73  ARG A C     1 
ATOM   487  O  O     . ARG A 1 155 ? 33.107 -15.561 -21.455 1.00 54.50  ? 73  ARG A O     1 
ATOM   488  C  CB    . ARG A 1 155 ? 33.573 -18.771 -20.820 1.00 63.50  ? 73  ARG A CB    1 
ATOM   489  C  CG    . ARG A 1 155 ? 33.407 -20.129 -21.495 1.00 61.61  ? 73  ARG A CG    1 
ATOM   490  C  CD    . ARG A 1 155 ? 32.148 -20.773 -20.945 1.00 69.19  ? 73  ARG A CD    1 
ATOM   491  N  NE    . ARG A 1 155 ? 32.068 -22.233 -20.953 1.00 79.19  ? 73  ARG A NE    1 
ATOM   492  C  CZ    . ARG A 1 155 ? 31.889 -23.002 -22.019 1.00 90.96  ? 73  ARG A CZ    1 
ATOM   493  N  NH1   . ARG A 1 155 ? 31.928 -22.494 -23.253 1.00 91.74  ? 73  ARG A NH1   1 
ATOM   494  N  NH2   . ARG A 1 155 ? 31.701 -24.298 -21.818 1.00 78.76  ? 73  ARG A NH2   1 
ATOM   495  N  N     . TRP A 1 156 ? 34.876 -15.962 -20.101 1.00 61.69  ? 74  TRP A N     1 
ATOM   496  C  CA    . TRP A 1 156 ? 34.764 -14.685 -19.423 1.00 54.95  ? 74  TRP A CA    1 
ATOM   497  C  C     . TRP A 1 156 ? 34.851 -13.560 -20.454 1.00 59.64  ? 74  TRP A C     1 
ATOM   498  O  O     . TRP A 1 156 ? 34.146 -12.555 -20.339 1.00 64.29  ? 74  TRP A O     1 
ATOM   499  C  CB    . TRP A 1 156 ? 35.812 -14.491 -18.316 1.00 49.96  ? 74  TRP A CB    1 
ATOM   500  C  CG    . TRP A 1 156 ? 35.892 -13.039 -17.929 1.00 47.23  ? 74  TRP A CG    1 
ATOM   501  C  CD1   . TRP A 1 156 ? 35.069 -12.386 -17.069 1.00 48.05  ? 74  TRP A CD1   1 
ATOM   502  C  CD2   . TRP A 1 156 ? 36.743 -12.026 -18.510 1.00 50.24  ? 74  TRP A CD2   1 
ATOM   503  N  NE1   . TRP A 1 156 ? 35.379 -11.056 -17.033 1.00 50.64  ? 74  TRP A NE1   1 
ATOM   504  C  CE2   . TRP A 1 156 ? 36.387 -10.803 -17.918 1.00 47.61  ? 74  TRP A CE2   1 
ATOM   505  C  CE3   . TRP A 1 156 ? 37.760 -12.038 -19.468 1.00 50.66  ? 74  TRP A CE3   1 
ATOM   506  C  CZ2   . TRP A 1 156 ? 37.014 -9.610  -18.243 1.00 49.01  ? 74  TRP A CZ2   1 
ATOM   507  C  CZ3   . TRP A 1 156 ? 38.374 -10.856 -19.800 1.00 47.30  ? 74  TRP A CZ3   1 
ATOM   508  C  CH2   . TRP A 1 156 ? 38.001 -9.665  -19.194 1.00 51.63  ? 74  TRP A CH2   1 
ATOM   509  N  N     . ARG A 1 157 ? 35.717 -13.749 -21.454 1.00 52.71  ? 75  ARG A N     1 
ATOM   510  C  CA    . ARG A 1 157 ? 35.966 -12.726 -22.453 1.00 56.40  ? 75  ARG A CA    1 
ATOM   511  C  C     . ARG A 1 157 ? 34.760 -12.547 -23.375 1.00 58.90  ? 75  ARG A C     1 
ATOM   512  O  O     . ARG A 1 157 ? 34.525 -11.430 -23.834 1.00 57.20  ? 75  ARG A O     1 
ATOM   513  C  CB    . ARG A 1 157 ? 37.166 -13.122 -23.313 1.00 55.61  ? 75  ARG A CB    1 
ATOM   514  C  CG    . ARG A 1 157 ? 37.694 -11.947 -24.110 1.00 59.10  ? 75  ARG A CG    1 
ATOM   515  C  CD    . ARG A 1 157 ? 38.825 -12.357 -25.018 1.00 64.94  ? 75  ARG A CD    1 
ATOM   516  N  NE    . ARG A 1 157 ? 39.414 -11.147 -25.585 1.00 66.71  ? 75  ARG A NE    1 
ATOM   517  C  CZ    . ARG A 1 157 ? 40.083 -10.227 -24.903 1.00 63.14  ? 75  ARG A CZ    1 
ATOM   518  N  NH1   . ARG A 1 157 ? 40.430 -10.391 -23.635 1.00 61.17  ? 75  ARG A NH1   1 
ATOM   519  N  NH2   . ARG A 1 157 ? 40.448 -9.134  -25.529 1.00 68.84  ? 75  ARG A NH2   1 
ATOM   520  N  N     . ARG A 1 158 ? 34.053 -13.657 -23.660 1.00 58.83  ? 76  ARG A N     1 
ATOM   521  C  CA    . ARG A 1 158 ? 32.945 -13.689 -24.601 1.00 57.46  ? 76  ARG A CA    1 
ATOM   522  C  C     . ARG A 1 158 ? 31.658 -13.289 -23.880 1.00 58.11  ? 76  ARG A C     1 
ATOM   523  O  O     . ARG A 1 158 ? 30.606 -13.235 -24.492 1.00 66.14  ? 76  ARG A O     1 
ATOM   524  C  CB    . ARG A 1 158 ? 32.792 -15.058 -25.293 1.00 59.03  ? 76  ARG A CB    1 
ATOM   525  C  CG    . ARG A 1 158 ? 33.848 -15.403 -26.343 1.00 66.96  ? 76  ARG A CG    1 
ATOM   526  C  CD    . ARG A 1 158 ? 33.630 -16.664 -27.195 1.00 68.25  ? 76  ARG A CD    1 
ATOM   527  N  NE    . ARG A 1 158 ? 33.167 -17.815 -26.407 1.00 83.34  ? 76  ARG A NE    1 
ATOM   528  C  CZ    . ARG A 1 158 ? 33.886 -18.871 -25.963 1.00 98.33  ? 76  ARG A CZ    1 
ATOM   529  N  NH1   . ARG A 1 158 ? 35.172 -18.991 -26.264 1.00 82.82  ? 76  ARG A NH1   1 
ATOM   530  N  NH2   . ARG A 1 158 ? 33.320 -19.807 -25.198 1.00 92.94  ? 76  ARG A NH2   1 
ATOM   531  N  N     . GLY A 1 159 ? 31.720 -13.035 -22.572 1.00 61.05  ? 77  GLY A N     1 
ATOM   532  C  CA    . GLY A 1 159 ? 30.531 -12.653 -21.820 1.00 59.01  ? 77  GLY A CA    1 
ATOM   533  C  C     . GLY A 1 159 ? 29.691 -13.847 -21.350 1.00 58.69  ? 77  GLY A C     1 
ATOM   534  O  O     . GLY A 1 159 ? 28.684 -13.651 -20.691 1.00 55.97  ? 77  GLY A O     1 
ATOM   535  N  N     . GLU A 1 160 ? 30.131 -15.083 -21.602 1.00 56.67  ? 78  GLU A N     1 
ATOM   536  C  CA    . GLU A 1 160 ? 29.416 -16.262 -21.139 1.00 56.66  ? 78  GLU A CA    1 
ATOM   537  C  C     . GLU A 1 160 ? 29.715 -16.609 -19.678 1.00 54.63  ? 78  GLU A C     1 
ATOM   538  O  O     . GLU A 1 160 ? 29.146 -17.547 -19.136 1.00 53.50  ? 78  GLU A O     1 
ATOM   539  C  CB    . GLU A 1 160 ? 29.813 -17.439 -22.027 1.00 58.56  ? 78  GLU A CB    1 
ATOM   540  C  CG    . GLU A 1 160 ? 29.474 -17.187 -23.492 1.00 62.09  ? 78  GLU A CG    1 
ATOM   541  C  CD    . GLU A 1 160 ? 30.198 -18.136 -24.415 1.00 71.83  ? 78  GLU A CD    1 
ATOM   542  O  OE1   . GLU A 1 160 ? 30.924 -19.031 -23.921 1.00 76.78  ? 78  GLU A OE1   1 
ATOM   543  O  OE2   . GLU A 1 160 ? 30.031 -17.963 -25.642 1.00 86.43  ? 78  GLU A OE2   1 
ATOM   544  N  N     . LEU A 1 161 ? 30.642 -15.905 -19.035 1.00 63.20  ? 79  LEU A N     1 
ATOM   545  C  CA    . LEU A 1 161 ? 31.072 -16.265 -17.689 1.00 60.57  ? 79  LEU A CA    1 
ATOM   546  C  C     . LEU A 1 161 ? 31.532 -14.988 -17.013 1.00 52.71  ? 79  LEU A C     1 
ATOM   547  O  O     . LEU A 1 161 ? 32.014 -14.081 -17.691 1.00 49.48  ? 79  LEU A O     1 
ATOM   548  C  CB    . LEU A 1 161 ? 32.187 -17.307 -17.734 1.00 64.97  ? 79  LEU A CB    1 
ATOM   549  C  CG    . LEU A 1 161 ? 32.724 -17.796 -16.385 1.00 66.49  ? 79  LEU A CG    1 
ATOM   550  C  CD1   . LEU A 1 161 ? 33.245 -19.226 -16.517 1.00 65.95  ? 79  LEU A CD1   1 
ATOM   551  C  CD2   . LEU A 1 161 ? 33.848 -16.918 -15.847 1.00 67.15  ? 79  LEU A CD2   1 
ATOM   552  N  N     . ASN A 1 162 ? 31.365 -14.934 -15.695 1.00 47.35  ? 80  ASN A N     1 
ATOM   553  C  CA    . ASN A 1 162 ? 31.618 -13.705 -14.964 1.00 53.46  ? 80  ASN A CA    1 
ATOM   554  C  C     . ASN A 1 162 ? 32.749 -13.833 -13.939 1.00 54.27  ? 80  ASN A C     1 
ATOM   555  O  O     . ASN A 1 162 ? 33.137 -14.931 -13.521 1.00 52.46  ? 80  ASN A O     1 
ATOM   556  C  CB    . ASN A 1 162 ? 30.335 -13.259 -14.284 1.00 65.45  ? 80  ASN A CB    1 
ATOM   557  C  CG    . ASN A 1 162 ? 29.419 -12.560 -15.252 1.00 67.81  ? 80  ASN A CG    1 
ATOM   558  O  OD1   . ASN A 1 162 ? 29.850 -12.116 -16.327 1.00 76.11  ? 80  ASN A OD1   1 
ATOM   559  N  ND2   . ASN A 1 162 ? 28.175 -12.398 -14.850 1.00 61.16  ? 80  ASN A ND2   1 
ATOM   560  N  N     . ILE A 1 163 ? 33.195 -12.660 -13.478 1.00 47.67  ? 81  ILE A N     1 
ATOM   561  C  CA    . ILE A 1 163 ? 34.340 -12.531 -12.596 1.00 48.14  ? 81  ILE A CA    1 
ATOM   562  C  C     . ILE A 1 163 ? 34.160 -13.444 -11.398 1.00 55.06  ? 81  ILE A C     1 
ATOM   563  O  O     . ILE A 1 163 ? 35.116 -14.106 -10.999 1.00 54.66  ? 81  ILE A O     1 
ATOM   564  C  CB    . ILE A 1 163 ? 34.561 -11.068 -12.172 1.00 48.78  ? 81  ILE A CB    1 
ATOM   565  C  CG1   . ILE A 1 163 ? 35.170 -10.260 -13.313 1.00 50.21  ? 81  ILE A CG1   1 
ATOM   566  C  CG2   . ILE A 1 163 ? 35.424 -10.956 -10.917 1.00 50.34  ? 81  ILE A CG2   1 
ATOM   567  C  CD1   . ILE A 1 163 ? 34.858 -8.779  -13.251 1.00 53.46  ? 81  ILE A CD1   1 
ATOM   568  N  N     . TRP A 1 164 ? 32.944 -13.496 -10.837 1.00 58.67  ? 82  TRP A N     1 
ATOM   569  C  CA    . TRP A 1 164 ? 32.795 -14.149 -9.545  1.00 55.64  ? 82  TRP A CA    1 
ATOM   570  C  C     . TRP A 1 164 ? 33.038 -15.637 -9.717  1.00 50.04  ? 82  TRP A C     1 
ATOM   571  O  O     . TRP A 1 164 ? 33.462 -16.309 -8.788  1.00 53.77  ? 82  TRP A O     1 
ATOM   572  C  CB    . TRP A 1 164 ? 31.439 -13.847 -8.885  1.00 63.32  ? 82  TRP A CB    1 
ATOM   573  C  CG    . TRP A 1 164 ? 30.245 -14.353 -9.640  1.00 67.81  ? 82  TRP A CG    1 
ATOM   574  C  CD1   . TRP A 1 164 ? 29.554 -13.690 -10.613 1.00 79.03  ? 82  TRP A CD1   1 
ATOM   575  C  CD2   . TRP A 1 164 ? 29.609 -15.640 -9.488  1.00 69.91  ? 82  TRP A CD2   1 
ATOM   576  N  NE1   . TRP A 1 164 ? 28.534 -14.473 -11.084 1.00 83.58  ? 82  TRP A NE1   1 
ATOM   577  C  CE2   . TRP A 1 164 ? 28.539 -15.673 -10.413 1.00 77.35  ? 82  TRP A CE2   1 
ATOM   578  C  CE3   . TRP A 1 164 ? 29.831 -16.758 -8.672  1.00 69.57  ? 82  TRP A CE3   1 
ATOM   579  C  CZ2   . TRP A 1 164 ? 27.706 -16.786 -10.539 1.00 62.76  ? 82  TRP A CZ2   1 
ATOM   580  C  CZ3   . TRP A 1 164 ? 29.002 -17.856 -8.797  1.00 66.55  ? 82  TRP A CZ3   1 
ATOM   581  C  CH2   . TRP A 1 164 ? 27.961 -17.870 -9.724  1.00 67.00  ? 82  TRP A CH2   1 
ATOM   582  N  N     . GLU A 1 165 ? 32.831 -16.135 -10.934 1.00 51.81  ? 83  GLU A N     1 
ATOM   583  C  CA    . GLU A 1 165 ? 32.937 -17.564 -11.170 1.00 56.40  ? 83  GLU A CA    1 
ATOM   584  C  C     . GLU A 1 165 ? 34.405 -17.948 -11.377 1.00 52.59  ? 83  GLU A C     1 
ATOM   585  O  O     . GLU A 1 165 ? 34.842 -19.041 -11.032 1.00 52.61  ? 83  GLU A O     1 
ATOM   586  C  CB    . GLU A 1 165 ? 32.068 -17.937 -12.376 1.00 67.83  ? 83  GLU A CB    1 
ATOM   587  C  CG    . GLU A 1 165 ? 30.574 -17.616 -12.248 1.00 67.78  ? 83  GLU A CG    1 
ATOM   588  C  CD    . GLU A 1 165 ? 29.821 -17.794 -13.564 1.00 67.42  ? 83  GLU A CD    1 
ATOM   589  O  OE1   . GLU A 1 165 ? 29.614 -18.949 -13.956 1.00 68.96  ? 83  GLU A OE1   1 
ATOM   590  O  OE2   . GLU A 1 165 ? 29.504 -16.802 -14.243 1.00 70.25  ? 83  GLU A OE2   1 
ATOM   591  N  N     . GLU A 1 166 ? 35.174 -17.046 -11.987 1.00 51.56  ? 84  GLU A N     1 
ATOM   592  C  CA    . GLU A 1 166 ? 36.599 -17.267 -12.179 1.00 51.92  ? 84  GLU A CA    1 
ATOM   593  C  C     . GLU A 1 166 ? 37.284 -17.219 -10.815 1.00 46.78  ? 84  GLU A C     1 
ATOM   594  O  O     . GLU A 1 166 ? 38.043 -18.125 -10.485 1.00 43.38  ? 84  GLU A O     1 
ATOM   595  C  CB    . GLU A 1 166 ? 37.133 -16.258 -13.200 1.00 53.01  ? 84  GLU A CB    1 
ATOM   596  C  CG    . GLU A 1 166 ? 38.644 -16.098 -13.164 1.00 50.22  ? 84  GLU A CG    1 
ATOM   597  C  CD    . GLU A 1 166 ? 39.100 -15.277 -11.983 1.00 43.87  ? 84  GLU A CD    1 
ATOM   598  O  OE1   . GLU A 1 166 ? 38.647 -14.110 -11.874 1.00 39.87  ? 84  GLU A OE1   1 
ATOM   599  O  OE2   . GLU A 1 166 ? 39.932 -15.814 -11.203 1.00 47.09  ? 84  GLU A OE2   1 
ATOM   600  N  N     . HIS A 1 167 ? 36.956 -16.185 -10.023 1.00 46.29  ? 85  HIS A N     1 
ATOM   601  C  CA    . HIS A 1 167 ? 37.522 -15.979 -8.697  1.00 48.65  ? 85  HIS A CA    1 
ATOM   602  C  C     . HIS A 1 167 ? 37.348 -17.211 -7.813  1.00 49.71  ? 85  HIS A C     1 
ATOM   603  O  O     . HIS A 1 167 ? 38.258 -17.542 -7.063  1.00 60.39  ? 85  HIS A O     1 
ATOM   604  C  CB    . HIS A 1 167 ? 36.946 -14.727 -8.010  1.00 47.66  ? 85  HIS A CB    1 
ATOM   605  C  CG    . HIS A 1 167 ? 37.647 -13.446 -8.313  1.00 45.63  ? 85  HIS A CG    1 
ATOM   606  N  ND1   . HIS A 1 167 ? 38.135 -13.108 -9.568  1.00 43.12  ? 85  HIS A ND1   1 
ATOM   607  C  CD2   . HIS A 1 167 ? 37.897 -12.389 -7.505  1.00 48.59  ? 85  HIS A CD2   1 
ATOM   608  C  CE1   . HIS A 1 167 ? 38.632 -11.877 -9.518  1.00 49.98  ? 85  HIS A CE1   1 
ATOM   609  N  NE2   . HIS A 1 167 ? 38.514 -11.419 -8.270  1.00 51.93  ? 85  HIS A NE2   1 
ATOM   610  N  N     . LEU A 1 168 ? 36.185 -17.875 -7.877  1.00 54.31  ? 86  LEU A N     1 
ATOM   611  C  CA    . LEU A 1 168 ? 35.957 -19.074 -7.077  1.00 54.06  ? 86  LEU A CA    1 
ATOM   612  C  C     . LEU A 1 168 ? 36.806 -20.222 -7.621  1.00 49.27  ? 86  LEU A C     1 
ATOM   613  O  O     . LEU A 1 168 ? 37.429 -20.960 -6.862  1.00 47.68  ? 86  LEU A O     1 
ATOM   614  C  CB    . LEU A 1 168 ? 34.475 -19.434 -7.089  1.00 56.81  ? 86  LEU A CB    1 
ATOM   615  C  CG    . LEU A 1 168 ? 33.550 -18.520 -6.292  1.00 61.87  ? 86  LEU A CG    1 
ATOM   616  C  CD1   . LEU A 1 168 ? 32.132 -18.924 -6.614  1.00 67.78  ? 86  LEU A CD1   1 
ATOM   617  C  CD2   . LEU A 1 168 ? 33.840 -18.606 -4.801  1.00 66.75  ? 86  LEU A CD2   1 
ATOM   618  N  N     . ALA A 1 169 ? 36.820 -20.361 -8.950  1.00 45.24  ? 87  ALA A N     1 
ATOM   619  C  CA    . ALA A 1 169 ? 37.611 -21.376 -9.617  1.00 53.95  ? 87  ALA A CA    1 
ATOM   620  C  C     . ALA A 1 169 ? 39.092 -21.234 -9.257  1.00 57.41  ? 87  ALA A C     1 
ATOM   621  O  O     . ALA A 1 169 ? 39.774 -22.221 -8.940  1.00 55.13  ? 87  ALA A O     1 
ATOM   622  C  CB    . ALA A 1 169 ? 37.379 -21.270 -11.115 1.00 60.05  ? 87  ALA A CB    1 
ATOM   623  N  N     . SER A 1 170 ? 39.584 -19.989 -9.303  1.00 52.08  ? 88  SER A N     1 
ATOM   624  C  CA    . SER A 1 170 ? 40.954 -19.693 -8.903  1.00 50.06  ? 88  SER A CA    1 
ATOM   625  C  C     . SER A 1 170 ? 41.209 -20.135 -7.457  1.00 46.21  ? 88  SER A C     1 
ATOM   626  O  O     . SER A 1 170 ? 42.146 -20.883 -7.201  1.00 45.46  ? 88  SER A O     1 
ATOM   627  C  CB    . SER A 1 170 ? 41.287 -18.239 -9.139  1.00 47.88  ? 88  SER A CB    1 
ATOM   628  O  OG    . SER A 1 170 ? 41.379 -17.966 -10.537 1.00 43.02  ? 88  SER A OG    1 
ATOM   629  N  N     . GLN A 1 171 ? 40.361 -19.741 -6.498  1.00 48.65  ? 89  GLN A N     1 
ATOM   630  C  CA    . GLN A 1 171 ? 40.583 -20.156 -5.113  1.00 53.02  ? 89  GLN A CA    1 
ATOM   631  C  C     . GLN A 1 171 ? 40.492 -21.672 -4.955  1.00 56.69  ? 89  GLN A C     1 
ATOM   632  O  O     . GLN A 1 171 ? 41.334 -22.261 -4.277  1.00 64.09  ? 89  GLN A O     1 
ATOM   633  C  CB    . GLN A 1 171 ? 39.588 -19.561 -4.126  1.00 55.44  ? 89  GLN A CB    1 
ATOM   634  C  CG    . GLN A 1 171 ? 39.716 -18.056 -3.973  1.00 50.46  ? 89  GLN A CG    1 
ATOM   635  C  CD    . GLN A 1 171 ? 41.125 -17.636 -3.625  1.00 52.55  ? 89  GLN A CD    1 
ATOM   636  O  OE1   . GLN A 1 171 ? 41.648 -17.972 -2.559  1.00 54.14  ? 89  GLN A OE1   1 
ATOM   637  N  NE2   . GLN A 1 171 ? 41.733 -16.857 -4.507  1.00 49.78  ? 89  GLN A NE2   1 
ATOM   638  N  N     . VAL A 1 172 ? 39.483 -22.299 -5.582  1.00 55.99  ? 90  VAL A N     1 
ATOM   639  C  CA    . VAL A 1 172 ? 39.340 -23.750 -5.524  1.00 59.19  ? 90  VAL A CA    1 
ATOM   640  C  C     . VAL A 1 172 ? 40.624 -24.414 -6.026  1.00 61.07  ? 90  VAL A C     1 
ATOM   641  O  O     . VAL A 1 172 ? 41.149 -25.313 -5.367  1.00 69.81  ? 90  VAL A O     1 
ATOM   642  C  CB    . VAL A 1 172 ? 38.107 -24.271 -6.294  1.00 61.04  ? 90  VAL A CB    1 
ATOM   643  C  CG1   . VAL A 1 172 ? 38.202 -25.764 -6.574  1.00 58.80  ? 90  VAL A CG1   1 
ATOM   644  C  CG2   . VAL A 1 172 ? 36.788 -23.942 -5.576  1.00 56.05  ? 90  VAL A CG2   1 
ATOM   645  N  N     . THR A 1 173 ? 41.133 -23.967 -7.181  1.00 56.93  ? 91  THR A N     1 
ATOM   646  C  CA    . THR A 1 173 ? 42.245 -24.648 -7.824  1.00 58.20  ? 91  THR A CA    1 
ATOM   647  C  C     . THR A 1 173 ? 43.522 -24.514 -6.987  1.00 55.41  ? 91  THR A C     1 
ATOM   648  O  O     . THR A 1 173 ? 44.314 -25.446 -6.924  1.00 55.04  ? 91  THR A O     1 
ATOM   649  C  CB    . THR A 1 173 ? 42.464 -24.122 -9.244  1.00 57.71  ? 91  THR A CB    1 
ATOM   650  O  OG1   . THR A 1 173 ? 41.246 -24.207 -9.982  1.00 50.86  ? 91  THR A OG1   1 
ATOM   651  C  CG2   . THR A 1 173 ? 43.571 -24.886 -9.949  1.00 50.56  ? 91  THR A CG2   1 
ATOM   652  N  N     . LEU A 1 174 ? 43.755 -23.353 -6.375  1.00 53.50  ? 92  LEU A N     1 
ATOM   653  C  CA    . LEU A 1 174 ? 44.953 -23.162 -5.566  1.00 51.63  ? 92  LEU A CA    1 
ATOM   654  C  C     . LEU A 1 174 ? 44.878 -24.069 -4.338  1.00 52.71  ? 92  LEU A C     1 
ATOM   655  O  O     . LEU A 1 174 ? 45.896 -24.569 -3.861  1.00 60.54  ? 92  LEU A O     1 
ATOM   656  C  CB    . LEU A 1 174 ? 45.115 -21.704 -5.119  1.00 49.60  ? 92  LEU A CB    1 
ATOM   657  C  CG    . LEU A 1 174 ? 45.485 -20.674 -6.187  1.00 49.95  ? 92  LEU A CG    1 
ATOM   658  C  CD1   . LEU A 1 174 ? 45.181 -19.219 -5.754  1.00 46.20  ? 92  LEU A CD1   1 
ATOM   659  C  CD2   . LEU A 1 174 ? 46.942 -20.851 -6.498  1.00 52.66  ? 92  LEU A CD2   1 
ATOM   660  N  N     . ALA A 1 175 ? 43.670 -24.223 -3.790  1.00 58.93  ? 93  ALA A N     1 
ATOM   661  C  CA    . ALA A 1 175 ? 43.499 -24.954 -2.549  1.00 58.34  ? 93  ALA A CA    1 
ATOM   662  C  C     . ALA A 1 175 ? 43.581 -26.450 -2.833  1.00 57.49  ? 93  ALA A C     1 
ATOM   663  O  O     . ALA A 1 175 ? 44.224 -27.170 -2.062  1.00 64.93  ? 93  ALA A O     1 
ATOM   664  C  CB    . ALA A 1 175 ? 42.207 -24.540 -1.886  1.00 56.83  ? 93  ALA A CB    1 
ATOM   665  N  N     . ALA A 1 176 ? 43.021 -26.873 -3.985  1.00 58.72  ? 94  ALA A N     1 
ATOM   666  C  CA    . ALA A 1 176 ? 42.864 -28.287 -4.342  1.00 66.23  ? 94  ALA A CA    1 
ATOM   667  C  C     . ALA A 1 176 ? 44.180 -28.924 -4.790  1.00 65.29  ? 94  ALA A C     1 
ATOM   668  O  O     . ALA A 1 176 ? 44.448 -30.103 -4.533  1.00 68.64  ? 94  ALA A O     1 
ATOM   669  C  CB    . ALA A 1 176 ? 41.809 -28.433 -5.427  1.00 64.64  ? 94  ALA A CB    1 
ATOM   670  N  N     . THR A 1 177 ? 44.992 -28.126 -5.478  1.00 61.45  ? 95  THR A N     1 
ATOM   671  C  CA    . THR A 1 177 ? 46.301 -28.552 -5.938  1.00 61.32  ? 95  THR A CA    1 
ATOM   672  C  C     . THR A 1 177 ? 47.218 -28.798 -4.728  1.00 57.81  ? 95  THR A C     1 
ATOM   673  O  O     . THR A 1 177 ? 47.940 -29.790 -4.669  1.00 52.08  ? 95  THR A O     1 
ATOM   674  C  CB    . THR A 1 177 ? 46.770 -27.447 -6.890  1.00 54.61  ? 95  THR A CB    1 
ATOM   675  O  OG1   . THR A 1 177 ? 47.685 -27.986 -7.822  1.00 69.58  ? 95  THR A OG1   1 
ATOM   676  C  CG2   . THR A 1 177 ? 47.454 -26.294 -6.186  1.00 56.55  ? 95  THR A CG2   1 
ATOM   677  N  N     . GLU A 1 178 ? 47.161 -27.904 -3.735  1.00 55.95  ? 96  GLU A N     1 
ATOM   678  C  CA    . GLU A 1 178 ? 47.991 -27.993 -2.545  1.00 55.48  ? 96  GLU A CA    1 
ATOM   679  C  C     . GLU A 1 178 ? 47.525 -29.197 -1.720  1.00 59.49  ? 96  GLU A C     1 
ATOM   680  O  O     . GLU A 1 178 ? 48.348 -30.043 -1.363  1.00 53.48  ? 96  GLU A O     1 
ATOM   681  C  CB    . GLU A 1 178 ? 47.972 -26.652 -1.793  1.00 58.39  ? 96  GLU A CB    1 
ATOM   682  C  CG    . GLU A 1 178 ? 48.703 -26.659 -0.444  1.00 64.24  ? 96  GLU A CG    1 
ATOM   683  C  CD    . GLU A 1 178 ? 50.162 -27.133 -0.453  1.00 75.97  ? 96  GLU A CD    1 
ATOM   684  O  OE1   . GLU A 1 178 ? 50.949 -26.704 -1.336  1.00 79.70  ? 96  GLU A OE1   1 
ATOM   685  O  OE2   . GLU A 1 178 ? 50.540 -27.931 0.436   1.00 75.42  ? 96  GLU A OE2   1 
ATOM   686  N  N     . HIS A 1 179 ? 46.203 -29.273 -1.474  1.00 60.37  ? 97  HIS A N     1 
ATOM   687  C  CA    . HIS A 1 179 ? 45.554 -30.384 -0.785  1.00 66.86  ? 97  HIS A CA    1 
ATOM   688  C  C     . HIS A 1 179 ? 46.052 -31.735 -1.315  1.00 60.57  ? 97  HIS A C     1 
ATOM   689  O  O     . HIS A 1 179 ? 46.405 -32.623 -0.536  1.00 63.13  ? 97  HIS A O     1 
ATOM   690  C  CB    . HIS A 1 179 ? 44.025 -30.199 -0.817  1.00 82.67  ? 97  HIS A CB    1 
ATOM   691  C  CG    . HIS A 1 179 ? 43.249 -30.989 0.204   1.00 103.12 ? 97  HIS A CG    1 
ATOM   692  N  ND1   . HIS A 1 179 ? 42.967 -32.341 0.097   1.00 105.43 ? 97  HIS A ND1   1 
ATOM   693  C  CD2   . HIS A 1 179 ? 42.696 -30.589 1.363   1.00 105.01 ? 97  HIS A CD2   1 
ATOM   694  C  CE1   . HIS A 1 179 ? 42.253 -32.736 1.144   1.00 101.52 ? 97  HIS A CE1   1 
ATOM   695  N  NE2   . HIS A 1 179 ? 42.076 -31.688 1.925   1.00 111.58 ? 97  HIS A NE2   1 
ATOM   696  N  N     . LEU A 1 180 ? 46.123 -31.886 -2.641  1.00 54.43  ? 98  LEU A N     1 
ATOM   697  C  CA    . LEU A 1 180 ? 46.611 -33.114 -3.251  1.00 53.50  ? 98  LEU A CA    1 
ATOM   698  C  C     . LEU A 1 180 ? 48.119 -33.269 -3.075  1.00 57.92  ? 98  LEU A C     1 
ATOM   699  O  O     . LEU A 1 180 ? 48.610 -34.380 -2.878  1.00 54.80  ? 98  LEU A O     1 
ATOM   700  C  CB    . LEU A 1 180 ? 46.257 -33.085 -4.737  1.00 59.36  ? 98  LEU A CB    1 
ATOM   701  C  CG    . LEU A 1 180 ? 46.774 -34.262 -5.568  1.00 64.53  ? 98  LEU A CG    1 
ATOM   702  C  CD1   . LEU A 1 180 ? 46.237 -35.588 -5.043  1.00 59.13  ? 98  LEU A CD1   1 
ATOM   703  C  CD2   . LEU A 1 180 ? 46.428 -34.082 -7.051  1.00 72.36  ? 98  LEU A CD2   1 
ATOM   704  N  N     . HIS A 1 181 ? 48.856 -32.159 -3.236  1.00 50.68  ? 99  HIS A N     1 
ATOM   705  C  CA    . HIS A 1 181 ? 50.308 -32.197 -3.253  1.00 48.00  ? 99  HIS A CA    1 
ATOM   706  C  C     . HIS A 1 181 ? 50.869 -32.617 -1.901  1.00 46.76  ? 99  HIS A C     1 
ATOM   707  O  O     . HIS A 1 181 ? 51.889 -33.294 -1.870  1.00 43.04  ? 99  HIS A O     1 
ATOM   708  C  CB    . HIS A 1 181 ? 50.880 -30.823 -3.607  1.00 52.08  ? 99  HIS A CB    1 
ATOM   709  C  CG    . HIS A 1 181 ? 52.357 -30.676 -3.546  1.00 46.46  ? 99  HIS A CG    1 
ATOM   710  N  ND1   . HIS A 1 181 ? 53.239 -31.279 -4.428  1.00 46.39  ? 99  HIS A ND1   1 
ATOM   711  C  CD2   . HIS A 1 181 ? 53.099 -29.925 -2.703  1.00 45.69  ? 99  HIS A CD2   1 
ATOM   712  C  CE1   . HIS A 1 181 ? 54.481 -30.899 -4.114  1.00 47.52  ? 99  HIS A CE1   1 
ATOM   713  N  NE2   . HIS A 1 181 ? 54.427 -30.051 -3.077  1.00 40.91  ? 99  HIS A NE2   1 
ATOM   714  N  N     . ARG A 1 182 ? 50.231 -32.190 -0.796  1.00 47.79  ? 100 ARG A N     1 
ATOM   715  C  CA    . ARG A 1 182 ? 50.729 -32.530 0.535   1.00 52.85  ? 100 ARG A CA    1 
ATOM   716  C  C     . ARG A 1 182 ? 50.680 -34.046 0.757   1.00 55.25  ? 100 ARG A C     1 
ATOM   717  O  O     . ARG A 1 182 ? 51.376 -34.554 1.626   1.00 55.50  ? 100 ARG A O     1 
ATOM   718  C  CB    . ARG A 1 182 ? 50.059 -31.714 1.650   1.00 56.71  ? 100 ARG A CB    1 
ATOM   719  C  CG    . ARG A 1 182 ? 48.545 -31.736 1.617   1.00 73.68  ? 100 ARG A CG    1 
ATOM   720  C  CD    . ARG A 1 182 ? 47.882 -31.184 2.856   1.00 85.32  ? 100 ARG A CD    1 
ATOM   721  N  NE    . ARG A 1 182 ? 46.463 -31.571 2.849   1.00 97.99  ? 100 ARG A NE    1 
ATOM   722  C  CZ    . ARG A 1 182 ? 45.928 -32.651 3.432   1.00 109.04 ? 100 ARG A CZ    1 
ATOM   723  N  NH1   . ARG A 1 182 ? 46.676 -33.554 4.054   1.00 95.61  ? 100 ARG A NH1   1 
ATOM   724  N  NH2   . ARG A 1 182 ? 44.621 -32.829 3.371   1.00 116.22 ? 100 ARG A NH2   1 
ATOM   725  N  N     . GLN A 1 183 ? 49.920 -34.757 -0.091  1.00 59.17  ? 101 GLN A N     1 
ATOM   726  C  CA    . GLN A 1 183 ? 49.716 -36.187 0.014   1.00 58.15  ? 101 GLN A CA    1 
ATOM   727  C  C     . GLN A 1 183 ? 50.703 -36.972 -0.840  1.00 52.66  ? 101 GLN A C     1 
ATOM   728  O  O     . GLN A 1 183 ? 50.830 -38.170 -0.660  1.00 54.36  ? 101 GLN A O     1 
ATOM   729  C  CB    . GLN A 1 183 ? 48.346 -36.614 -0.517  1.00 68.57  ? 101 GLN A CB    1 
ATOM   730  C  CG    . GLN A 1 183 ? 47.144 -36.116 0.279   1.00 73.12  ? 101 GLN A CG    1 
ATOM   731  C  CD    . GLN A 1 183 ? 45.844 -36.653 -0.281  1.00 77.06  ? 101 GLN A CD    1 
ATOM   732  O  OE1   . GLN A 1 183 ? 45.667 -37.869 -0.446  1.00 82.30  ? 101 GLN A OE1   1 
ATOM   733  N  NE2   . GLN A 1 183 ? 44.930 -35.749 -0.608  1.00 81.79  ? 101 GLN A NE2   1 
ATOM   734  N  N     . LEU A 1 184 ? 51.368 -36.336 -1.803  1.00 57.89  ? 102 LEU A N     1 
ATOM   735  C  CA    . LEU A 1 184 ? 52.159 -37.077 -2.773  1.00 56.75  ? 102 LEU A CA    1 
ATOM   736  C  C     . LEU A 1 184 ? 53.513 -37.485 -2.200  1.00 58.02  ? 102 LEU A C     1 
ATOM   737  O  O     . LEU A 1 184 ? 54.182 -36.690 -1.530  1.00 53.22  ? 102 LEU A O     1 
ATOM   738  C  CB    . LEU A 1 184 ? 52.408 -36.225 -4.012  1.00 67.09  ? 102 LEU A CB    1 
ATOM   739  C  CG    . LEU A 1 184 ? 51.191 -35.761 -4.810  1.00 75.86  ? 102 LEU A CG    1 
ATOM   740  C  CD1   . LEU A 1 184 ? 51.761 -35.052 -6.043  1.00 76.48  ? 102 LEU A CD1   1 
ATOM   741  C  CD2   . LEU A 1 184 ? 50.250 -36.914 -5.161  1.00 75.97  ? 102 LEU A CD2   1 
ATOM   742  N  N     . PRO A 1 185 ? 54.023 -38.682 -2.566  1.00 53.81  ? 103 PRO A N     1 
ATOM   743  C  CA    . PRO A 1 185 ? 55.419 -39.031 -2.285  1.00 54.94  ? 103 PRO A CA    1 
ATOM   744  C  C     . PRO A 1 185 ? 56.375 -38.159 -3.103  1.00 52.79  ? 103 PRO A C     1 
ATOM   745  O  O     . PRO A 1 185 ? 55.992 -37.660 -4.174  1.00 54.37  ? 103 PRO A O     1 
ATOM   746  C  CB    . PRO A 1 185 ? 55.521 -40.521 -2.658  1.00 51.08  ? 103 PRO A CB    1 
ATOM   747  C  CG    . PRO A 1 185 ? 54.446 -40.687 -3.714  1.00 55.27  ? 103 PRO A CG    1 
ATOM   748  C  CD    . PRO A 1 185 ? 53.312 -39.723 -3.324  1.00 49.46  ? 103 PRO A CD    1 
ATOM   749  N  N     . ARG A 1 186 ? 57.617 -38.033 -2.597  1.00 47.24  ? 104 ARG A N     1 
ATOM   750  C  CA    . ARG A 1 186 ? 58.626 -37.122 -3.131  1.00 50.72  ? 104 ARG A CA    1 
ATOM   751  C  C     . ARG A 1 186 ? 59.975 -37.824 -3.178  1.00 46.84  ? 104 ARG A C     1 
ATOM   752  O  O     . ARG A 1 186 ? 60.356 -38.505 -2.245  1.00 52.75  ? 104 ARG A O     1 
ATOM   753  C  CB    . ARG A 1 186 ? 58.873 -35.874 -2.267  1.00 47.38  ? 104 ARG A CB    1 
ATOM   754  C  CG    . ARG A 1 186 ? 57.537 -35.330 -1.799  1.00 53.67  ? 104 ARG A CG    1 
ATOM   755  C  CD    . ARG A 1 186 ? 57.481 -33.851 -1.526  1.00 60.54  ? 104 ARG A CD    1 
ATOM   756  N  NE    . ARG A 1 186 ? 56.053 -33.511 -1.502  1.00 57.69  ? 104 ARG A NE    1 
ATOM   757  C  CZ    . ARG A 1 186 ? 55.555 -32.426 -0.914  1.00 58.06  ? 104 ARG A CZ    1 
ATOM   758  N  NH1   . ARG A 1 186 ? 56.380 -31.463 -0.477  1.00 48.36  ? 104 ARG A NH1   1 
ATOM   759  N  NH2   . ARG A 1 186 ? 54.230 -32.332 -0.776  1.00 52.76  ? 104 ARG A NH2   1 
ATOM   760  N  N     . ALA A 1 187 ? 60.705 -37.603 -4.261  1.00 47.76  ? 105 ALA A N     1 
ATOM   761  C  CA    . ALA A 1 187 ? 62.103 -37.959 -4.337  1.00 52.42  ? 105 ALA A CA    1 
ATOM   762  C  C     . ALA A 1 187 ? 62.813 -37.451 -3.086  1.00 52.38  ? 105 ALA A C     1 
ATOM   763  O  O     . ALA A 1 187 ? 62.410 -36.456 -2.501  1.00 53.09  ? 105 ALA A O     1 
ATOM   764  C  CB    . ALA A 1 187 ? 62.707 -37.354 -5.598  1.00 51.30  ? 105 ALA A CB    1 
ATOM   765  N  N     . PRO A 1 188 ? 63.897 -38.113 -2.646  1.00 57.71  ? 106 PRO A N     1 
ATOM   766  C  CA    . PRO A 1 188 ? 64.796 -37.528 -1.656  1.00 61.41  ? 106 PRO A CA    1 
ATOM   767  C  C     . PRO A 1 188 ? 65.316 -36.144 -2.037  1.00 54.98  ? 106 PRO A C     1 
ATOM   768  O  O     . PRO A 1 188 ? 65.498 -35.827 -3.204  1.00 57.60  ? 106 PRO A O     1 
ATOM   769  C  CB    . PRO A 1 188 ? 65.928 -38.572 -1.609  1.00 62.05  ? 106 PRO A CB    1 
ATOM   770  C  CG    . PRO A 1 188 ? 65.224 -39.855 -1.937  1.00 62.32  ? 106 PRO A CG    1 
ATOM   771  C  CD    . PRO A 1 188 ? 64.310 -39.460 -3.067  1.00 61.73  ? 106 PRO A CD    1 
ATOM   772  N  N     . PHE A 1 189 ? 65.597 -35.349 -1.009  1.00 54.73  ? 107 PHE A N     1 
ATOM   773  C  CA    . PHE A 1 189 ? 66.124 -34.018 -1.174  1.00 53.17  ? 107 PHE A CA    1 
ATOM   774  C  C     . PHE A 1 189 ? 67.370 -34.122 -2.038  1.00 53.08  ? 107 PHE A C     1 
ATOM   775  O  O     . PHE A 1 189 ? 68.267 -34.877 -1.690  1.00 57.10  ? 107 PHE A O     1 
ATOM   776  C  CB    . PHE A 1 189 ? 66.415 -33.414 0.207   1.00 53.54  ? 107 PHE A CB    1 
ATOM   777  C  CG    . PHE A 1 189 ? 67.021 -32.023 0.114   1.00 60.92  ? 107 PHE A CG    1 
ATOM   778  C  CD1   . PHE A 1 189 ? 66.553 -31.101 -0.830  1.00 57.58  ? 107 PHE A CD1   1 
ATOM   779  C  CD2   . PHE A 1 189 ? 68.112 -31.666 0.909   1.00 62.67  ? 107 PHE A CD2   1 
ATOM   780  C  CE1   . PHE A 1 189 ? 67.136 -29.838 -0.935  1.00 65.19  ? 107 PHE A CE1   1 
ATOM   781  C  CE2   . PHE A 1 189 ? 68.682 -30.391 0.811   1.00 66.45  ? 107 PHE A CE2   1 
ATOM   782  C  CZ    . PHE A 1 189 ? 68.196 -29.480 -0.114  1.00 63.71  ? 107 PHE A CZ    1 
ATOM   783  N  N     . ASN A 1 190 ? 67.433 -33.337 -3.126  1.00 51.28  ? 108 ASN A N     1 
ATOM   784  C  CA    . ASN A 1 190 ? 68.499 -33.453 -4.112  1.00 44.57  ? 108 ASN A CA    1 
ATOM   785  C  C     . ASN A 1 190 ? 69.588 -32.419 -3.846  1.00 44.83  ? 108 ASN A C     1 
ATOM   786  O  O     . ASN A 1 190 ? 70.490 -32.243 -4.654  1.00 45.49  ? 108 ASN A O     1 
ATOM   787  C  CB    . ASN A 1 190 ? 67.956 -33.307 -5.526  1.00 48.71  ? 108 ASN A CB    1 
ATOM   788  C  CG    . ASN A 1 190 ? 67.356 -31.937 -5.743  1.00 54.45  ? 108 ASN A CG    1 
ATOM   789  O  OD1   . ASN A 1 190 ? 67.654 -30.999 -5.002  1.00 55.56  ? 108 ASN A OD1   1 
ATOM   790  N  ND2   . ASN A 1 190 ? 66.499 -31.792 -6.734  1.00 56.34  ? 108 ASN A ND2   1 
ATOM   791  N  N     . GLY A 1 191 ? 69.486 -31.711 -2.720  1.00 47.29  ? 109 GLY A N     1 
ATOM   792  C  CA    . GLY A 1 191 ? 70.513 -30.760 -2.329  1.00 48.17  ? 109 GLY A CA    1 
ATOM   793  C  C     . GLY A 1 191 ? 70.367 -29.405 -3.024  1.00 49.57  ? 109 GLY A C     1 
ATOM   794  O  O     . GLY A 1 191 ? 71.208 -28.545 -2.818  1.00 53.39  ? 109 GLY A O     1 
ATOM   795  N  N     . ARG A 1 192 ? 69.319 -29.214 -3.843  1.00 47.09  ? 110 ARG A N     1 
ATOM   796  C  CA    . ARG A 1 192 ? 69.236 -28.083 -4.755  1.00 49.07  ? 110 ARG A CA    1 
ATOM   797  C  C     . ARG A 1 192 ? 68.099 -27.147 -4.369  1.00 48.32  ? 110 ARG A C     1 
ATOM   798  O  O     . ARG A 1 192 ? 67.119 -27.544 -3.731  1.00 48.53  ? 110 ARG A O     1 
ATOM   799  C  CB    . ARG A 1 192 ? 69.115 -28.540 -6.213  1.00 51.78  ? 110 ARG A CB    1 
ATOM   800  C  CG    . ARG A 1 192 ? 70.384 -29.257 -6.648  1.00 56.11  ? 110 ARG A CG    1 
ATOM   801  C  CD    . ARG A 1 192 ? 70.345 -29.700 -8.076  1.00 58.79  ? 110 ARG A CD    1 
ATOM   802  N  NE    . ARG A 1 192 ? 69.703 -31.010 -8.224  1.00 65.35  ? 110 ARG A NE    1 
ATOM   803  C  CZ    . ARG A 1 192 ? 70.195 -31.985 -8.957  1.00 60.43  ? 110 ARG A CZ    1 
ATOM   804  N  NH1   . ARG A 1 192 ? 71.450 -31.965 -9.345  1.00 69.37  ? 110 ARG A NH1   1 
ATOM   805  N  NH2   . ARG A 1 192 ? 69.419 -32.975 -9.326  1.00 65.41  ? 110 ARG A NH2   1 
ATOM   806  N  N     . LEU A 1 193 ? 68.253 -25.886 -4.789  1.00 52.49  ? 111 LEU A N     1 
ATOM   807  C  CA    . LEU A 1 193 ? 67.309 -24.837 -4.432  1.00 50.16  ? 111 LEU A CA    1 
ATOM   808  C  C     . LEU A 1 193 ? 66.792 -24.132 -5.686  1.00 47.10  ? 111 LEU A C     1 
ATOM   809  O  O     . LEU A 1 193 ? 67.580 -23.625 -6.487  1.00 46.18  ? 111 LEU A O     1 
ATOM   810  C  CB    . LEU A 1 193 ? 68.037 -23.888 -3.495  1.00 52.55  ? 111 LEU A CB    1 
ATOM   811  C  CG    . LEU A 1 193 ? 67.257 -22.657 -3.033  1.00 59.46  ? 111 LEU A CG    1 
ATOM   812  C  CD1   . LEU A 1 193 ? 66.291 -23.035 -1.955  1.00 65.25  ? 111 LEU A CD1   1 
ATOM   813  C  CD2   . LEU A 1 193 ? 68.196 -21.573 -2.548  1.00 60.98  ? 111 LEU A CD2   1 
ATOM   814  N  N     . ALA A 1 194 ? 65.458 -24.111 -5.842  1.00 44.74  ? 112 ALA A N     1 
ATOM   815  C  CA    . ALA A 1 194 ? 64.798 -23.349 -6.901  1.00 45.33  ? 112 ALA A CA    1 
ATOM   816  C  C     . ALA A 1 194 ? 64.130 -22.103 -6.322  1.00 42.86  ? 112 ALA A C     1 
ATOM   817  O  O     . ALA A 1 194 ? 63.483 -22.172 -5.282  1.00 42.76  ? 112 ALA A O     1 
ATOM   818  C  CB    . ALA A 1 194 ? 63.786 -24.183 -7.652  1.00 43.11  ? 112 ALA A CB    1 
ATOM   819  N  N     . LEU A 1 195 ? 64.330 -20.974 -7.022  1.00 47.06  ? 113 LEU A N     1 
ATOM   820  C  CA    . LEU A 1 195 ? 63.749 -19.675 -6.707  1.00 42.68  ? 113 LEU A CA    1 
ATOM   821  C  C     . LEU A 1 195 ? 62.796 -19.324 -7.832  1.00 43.74  ? 113 LEU A C     1 
ATOM   822  O  O     . LEU A 1 195 ? 63.193 -19.311 -9.001  1.00 42.01  ? 113 LEU A O     1 
ATOM   823  C  CB    . LEU A 1 195 ? 64.843 -18.619 -6.615  1.00 41.23  ? 113 LEU A CB    1 
ATOM   824  C  CG    . LEU A 1 195 ? 64.367 -17.191 -6.363  1.00 40.25  ? 113 LEU A CG    1 
ATOM   825  C  CD1   . LEU A 1 195 ? 63.982 -17.082 -4.927  1.00 43.17  ? 113 LEU A CD1   1 
ATOM   826  C  CD2   . LEU A 1 195 ? 65.385 -16.111 -6.691  1.00 45.63  ? 113 LEU A CD2   1 
ATOM   827  N  N     . CYS A 1 196 ? 61.551 -19.041 -7.443  1.00 48.51  ? 114 CYS A N     1 
ATOM   828  C  CA    . CYS A 1 196 ? 60.419 -18.963 -8.350  1.00 44.87  ? 114 CYS A CA    1 
ATOM   829  C  C     . CYS A 1 196 ? 59.535 -17.759 -8.031  1.00 44.91  ? 114 CYS A C     1 
ATOM   830  O  O     . CYS A 1 196 ? 59.283 -17.423 -6.864  1.00 38.69  ? 114 CYS A O     1 
ATOM   831  C  CB    . CYS A 1 196 ? 59.563 -20.212 -8.182  1.00 50.37  ? 114 CYS A CB    1 
ATOM   832  S  SG    . CYS A 1 196 ? 60.480 -21.746 -8.461  1.00 45.49  ? 114 CYS A SG    1 
ATOM   833  N  N     . GLY A 1 197 ? 59.011 -17.157 -9.101  1.00 42.52  ? 115 GLY A N     1 
ATOM   834  C  CA    . GLY A 1 197 ? 57.994 -16.137 -8.975  1.00 42.03  ? 115 GLY A CA    1 
ATOM   835  C  C     . GLY A 1 197 ? 57.472 -15.696 -10.333 1.00 42.71  ? 115 GLY A C     1 
ATOM   836  O  O     . GLY A 1 197 ? 57.893 -16.242 -11.353 1.00 38.85  ? 115 GLY A O     1 
ATOM   837  N  N     . CYS A 1 198 ? 56.551 -14.714 -10.312 1.00 44.46  ? 116 CYS A N     1 
ATOM   838  C  CA    . CYS A 1 198 ? 56.069 -14.069 -11.524 1.00 41.18  ? 116 CYS A CA    1 
ATOM   839  C  C     . CYS A 1 198 ? 56.525 -12.614 -11.552 1.00 41.98  ? 116 CYS A C     1 
ATOM   840  O  O     . CYS A 1 198 ? 56.762 -12.021 -10.490 1.00 42.67  ? 116 CYS A O     1 
ATOM   841  C  CB    . CYS A 1 198 ? 54.562 -14.142 -11.631 1.00 36.46  ? 116 CYS A CB    1 
ATOM   842  S  SG    . CYS A 1 198 ? 53.954 -15.782 -11.190 1.00 42.92  ? 116 CYS A SG    1 
ATOM   843  N  N     . PRO A 1 199 ? 56.678 -12.031 -12.765 1.00 39.88  ? 117 PRO A N     1 
ATOM   844  C  CA    . PRO A 1 199 ? 57.166 -10.665 -12.923 1.00 41.11  ? 117 PRO A CA    1 
ATOM   845  C  C     . PRO A 1 199 ? 56.196 -9.657  -12.338 1.00 38.99  ? 117 PRO A C     1 
ATOM   846  O  O     . PRO A 1 199 ? 55.013 -9.950  -12.176 1.00 39.83  ? 117 PRO A O     1 
ATOM   847  C  CB    . PRO A 1 199 ? 57.324 -10.417 -14.423 1.00 41.61  ? 117 PRO A CB    1 
ATOM   848  C  CG    . PRO A 1 199 ? 57.014 -11.738 -15.085 1.00 45.82  ? 117 PRO A CG    1 
ATOM   849  C  CD    . PRO A 1 199 ? 56.369 -12.652 -14.060 1.00 44.39  ? 117 PRO A CD    1 
ATOM   850  N  N     . GLU A 1 200 ? 56.749 -8.467  -12.096 1.00 42.87  ? 118 GLU A N     1 
ATOM   851  C  CA    . GLU A 1 200 ? 56.050 -7.324  -11.535 1.00 42.01  ? 118 GLU A CA    1 
ATOM   852  C  C     . GLU A 1 200 ? 54.825 -7.008  -12.369 1.00 40.01  ? 118 GLU A C     1 
ATOM   853  O  O     . GLU A 1 200 ? 54.891 -7.023  -13.593 1.00 44.24  ? 118 GLU A O     1 
ATOM   854  C  CB    . GLU A 1 200 ? 56.990 -6.116  -11.492 1.00 41.09  ? 118 GLU A CB    1 
ATOM   855  C  CG    . GLU A 1 200 ? 56.385 -4.850  -10.883 1.00 46.36  ? 118 GLU A CG    1 
ATOM   856  C  CD    . GLU A 1 200 ? 57.343 -3.706  -10.557 1.00 45.65  ? 118 GLU A CD    1 
ATOM   857  O  OE1   . GLU A 1 200 ? 58.554 -3.871  -10.863 1.00 42.04  ? 118 GLU A OE1   1 
ATOM   858  O  OE2   . GLU A 1 200 ? 56.904 -2.694  -9.958  1.00 38.00  ? 118 GLU A OE2   1 
ATOM   859  N  N     . GLY A 1 201 ? 53.713 -6.741  -11.679 1.00 44.43  ? 119 GLY A N     1 
ATOM   860  C  CA    . GLY A 1 201 ? 52.480 -6.344  -12.333 1.00 45.56  ? 119 GLY A CA    1 
ATOM   861  C  C     . GLY A 1 201 ? 51.660 -7.523  -12.864 1.00 46.81  ? 119 GLY A C     1 
ATOM   862  O  O     . GLY A 1 201 ? 50.560 -7.320  -13.358 1.00 50.20  ? 119 GLY A O     1 
ATOM   863  N  N     . ASP A 1 202 ? 52.182 -8.752  -12.790 1.00 47.02  ? 120 ASP A N     1 
ATOM   864  C  CA    . ASP A 1 202 ? 51.426 -9.921  -13.204 1.00 42.08  ? 120 ASP A CA    1 
ATOM   865  C  C     . ASP A 1 202 ? 50.925 -10.624 -11.945 1.00 40.78  ? 120 ASP A C     1 
ATOM   866  O  O     . ASP A 1 202 ? 51.679 -10.796 -11.003 1.00 46.09  ? 120 ASP A O     1 
ATOM   867  C  CB    . ASP A 1 202 ? 52.238 -10.783 -14.151 1.00 42.97  ? 120 ASP A CB    1 
ATOM   868  C  CG    . ASP A 1 202 ? 51.547 -12.032 -14.679 1.00 48.22  ? 120 ASP A CG    1 
ATOM   869  O  OD1   . ASP A 1 202 ? 50.359 -12.259 -14.312 1.00 41.06  ? 120 ASP A OD1   1 
ATOM   870  O  OD2   . ASP A 1 202 ? 52.212 -12.769 -15.442 1.00 42.32  ? 120 ASP A OD2   1 
ATOM   871  N  N     . LEU A 1 203 ? 49.635 -10.967 -11.932 1.00 42.34  ? 121 LEU A N     1 
ATOM   872  C  CA    . LEU A 1 203 ? 48.957 -11.453 -10.744 1.00 45.04  ? 121 LEU A CA    1 
ATOM   873  C  C     . LEU A 1 203 ? 48.604 -12.941 -10.870 1.00 43.30  ? 121 LEU A C     1 
ATOM   874  O  O     . LEU A 1 203 ? 48.183 -13.553 -9.884  1.00 45.01  ? 121 LEU A O     1 
ATOM   875  C  CB    . LEU A 1 203 ? 47.698 -10.615 -10.537 1.00 42.53  ? 121 LEU A CB    1 
ATOM   876  C  CG    . LEU A 1 203 ? 47.894 -9.157  -10.120 1.00 47.29  ? 121 LEU A CG    1 
ATOM   877  C  CD1   . LEU A 1 203 ? 46.495 -8.525  -9.985  1.00 45.53  ? 121 LEU A CD1   1 
ATOM   878  C  CD2   . LEU A 1 203 ? 48.698 -8.997  -8.821  1.00 44.74  ? 121 LEU A CD2   1 
ATOM   879  N  N     . HIS A 1 204 ? 48.761 -13.486 -12.078 1.00 38.50  ? 122 HIS A N     1 
ATOM   880  C  CA    . HIS A 1 204 ? 48.422 -14.861 -12.389 1.00 44.98  ? 122 HIS A CA    1 
ATOM   881  C  C     . HIS A 1 204 ? 49.518 -15.767 -11.851 1.00 43.09  ? 122 HIS A C     1 
ATOM   882  O  O     . HIS A 1 204 ? 50.639 -15.670 -12.326 1.00 40.56  ? 122 HIS A O     1 
ATOM   883  C  CB    . HIS A 1 204 ? 48.312 -15.085 -13.904 1.00 44.02  ? 122 HIS A CB    1 
ATOM   884  C  CG    . HIS A 1 204 ? 47.286 -14.240 -14.587 1.00 47.41  ? 122 HIS A CG    1 
ATOM   885  N  ND1   . HIS A 1 204 ? 47.445 -12.888 -14.815 1.00 48.83  ? 122 HIS A ND1   1 
ATOM   886  C  CD2   . HIS A 1 204 ? 46.091 -14.556 -15.116 1.00 55.42  ? 122 HIS A CD2   1 
ATOM   887  C  CE1   . HIS A 1 204 ? 46.385 -12.419 -15.461 1.00 45.85  ? 122 HIS A CE1   1 
ATOM   888  N  NE2   . HIS A 1 204 ? 45.543 -13.412 -15.664 1.00 51.38  ? 122 HIS A NE2   1 
ATOM   889  N  N     . GLU A 1 205 ? 49.160 -16.659 -10.906 1.00 43.39  ? 123 GLU A N     1 
ATOM   890  C  CA    . GLU A 1 205 ? 50.137 -17.417 -10.133 1.00 43.19  ? 123 GLU A CA    1 
ATOM   891  C  C     . GLU A 1 205 ? 49.805 -18.908 -9.998  1.00 45.41  ? 123 GLU A C     1 
ATOM   892  O  O     . GLU A 1 205 ? 50.557 -19.621 -9.319  1.00 44.36  ? 123 GLU A O     1 
ATOM   893  C  CB    . GLU A 1 205 ? 50.301 -16.816 -8.734  1.00 40.79  ? 123 GLU A CB    1 
ATOM   894  C  CG    . GLU A 1 205 ? 49.168 -17.172 -7.786  1.00 43.75  ? 123 GLU A CG    1 
ATOM   895  C  CD    . GLU A 1 205 ? 49.036 -16.302 -6.556  1.00 44.26  ? 123 GLU A CD    1 
ATOM   896  O  OE1   . GLU A 1 205 ? 49.975 -16.316 -5.760  1.00 49.55  ? 123 GLU A OE1   1 
ATOM   897  O  OE2   . GLU A 1 205 ? 48.021 -15.589 -6.411  1.00 51.02  ? 123 GLU A OE2   1 
ATOM   898  N  N     . ILE A 1 206 ? 48.704 -19.396 -10.603 1.00 44.60  ? 124 ILE A N     1 
ATOM   899  C  CA    . ILE A 1 206 ? 48.363 -20.806 -10.467 1.00 44.42  ? 124 ILE A CA    1 
ATOM   900  C  C     . ILE A 1 206 ? 49.414 -21.642 -11.211 1.00 49.13  ? 124 ILE A C     1 
ATOM   901  O  O     . ILE A 1 206 ? 49.893 -22.643 -10.678 1.00 45.07  ? 124 ILE A O     1 
ATOM   902  C  CB    . ILE A 1 206 ? 46.957 -21.107 -10.997 1.00 47.25  ? 124 ILE A CB    1 
ATOM   903  C  CG1   . ILE A 1 206 ? 45.874 -20.498 -10.173 1.00 46.33  ? 124 ILE A CG1   1 
ATOM   904  C  CG2   . ILE A 1 206 ? 46.746 -22.617 -11.161 1.00 48.19  ? 124 ILE A CG2   1 
ATOM   905  C  CD1   . ILE A 1 206 ? 44.529 -20.503 -10.896 1.00 46.84  ? 124 ILE A CD1   1 
ATOM   906  N  N     . ALA A 1 207 ? 49.792 -21.248 -12.438 1.00 38.94  ? 125 ALA A N     1 
ATOM   907  C  CA    . ALA A 1 207 ? 50.840 -21.990 -13.116 1.00 44.23  ? 125 ALA A CA    1 
ATOM   908  C  C     . ALA A 1 207 ? 52.104 -22.053 -12.255 1.00 42.26  ? 125 ALA A C     1 
ATOM   909  O  O     . ALA A 1 207 ? 52.791 -23.070 -12.204 1.00 42.32  ? 125 ALA A O     1 
ATOM   910  C  CB    . ALA A 1 207 ? 51.145 -21.357 -14.453 1.00 53.77  ? 125 ALA A CB    1 
ATOM   911  N  N     . LEU A 1 208 ? 52.440 -20.946 -11.589 1.00 42.29  ? 126 LEU A N     1 
ATOM   912  C  CA    . LEU A 1 208 ? 53.636 -20.935 -10.775 1.00 42.36  ? 126 LEU A CA    1 
ATOM   913  C  C     . LEU A 1 208 ? 53.550 -22.049 -9.735  1.00 41.35  ? 126 LEU A C     1 
ATOM   914  O  O     . LEU A 1 208 ? 54.545 -22.743 -9.498  1.00 37.89  ? 126 LEU A O     1 
ATOM   915  C  CB    . LEU A 1 208 ? 53.820 -19.591 -10.084 1.00 45.99  ? 126 LEU A CB    1 
ATOM   916  C  CG    . LEU A 1 208 ? 55.093 -19.519 -9.239  1.00 48.00  ? 126 LEU A CG    1 
ATOM   917  C  CD1   . LEU A 1 208 ? 56.294 -19.376 -10.161 1.00 44.85  ? 126 LEU A CD1   1 
ATOM   918  C  CD2   . LEU A 1 208 ? 55.029 -18.434 -8.188  1.00 53.22  ? 126 LEU A CD2   1 
ATOM   919  N  N     . HIS A 1 209 ? 52.365 -22.156 -9.104  1.00 40.13  ? 127 HIS A N     1 
ATOM   920  C  CA    . HIS A 1 209 ? 52.084 -23.158 -8.088  1.00 42.28  ? 127 HIS A CA    1 
ATOM   921  C  C     . HIS A 1 209 ? 52.238 -24.568 -8.658  1.00 49.06  ? 127 HIS A C     1 
ATOM   922  O  O     . HIS A 1 209 ? 52.859 -25.418 -8.016  1.00 48.24  ? 127 HIS A O     1 
ATOM   923  C  CB    . HIS A 1 209 ? 50.720 -22.910 -7.446  1.00 45.67  ? 127 HIS A CB    1 
ATOM   924  C  CG    . HIS A 1 209 ? 50.782 -21.939 -6.305  1.00 56.31  ? 127 HIS A CG    1 
ATOM   925  N  ND1   . HIS A 1 209 ? 50.920 -20.574 -6.457  1.00 52.10  ? 127 HIS A ND1   1 
ATOM   926  C  CD2   . HIS A 1 209 ? 50.789 -22.163 -4.989  1.00 57.56  ? 127 HIS A CD2   1 
ATOM   927  C  CE1   . HIS A 1 209 ? 50.983 -20.008 -5.266  1.00 51.35  ? 127 HIS A CE1   1 
ATOM   928  N  NE2   . HIS A 1 209 ? 50.903 -20.956 -4.368  1.00 49.54  ? 127 HIS A NE2   1 
ATOM   929  N  N     . LEU A 1 210 ? 51.714 -24.811 -9.874  1.00 46.42  ? 128 LEU A N     1 
ATOM   930  C  CA    . LEU A 1 210 ? 51.850 -26.123 -10.488 1.00 42.74  ? 128 LEU A CA    1 
ATOM   931  C  C     . LEU A 1 210 ? 53.335 -26.434 -10.648 1.00 42.91  ? 128 LEU A C     1 
ATOM   932  O  O     . LEU A 1 210 ? 53.762 -27.573 -10.424 1.00 42.02  ? 128 LEU A O     1 
ATOM   933  C  CB    . LEU A 1 210 ? 51.146 -26.256 -11.834 1.00 44.35  ? 128 LEU A CB    1 
ATOM   934  C  CG    . LEU A 1 210 ? 49.702 -25.754 -11.924 1.00 41.92  ? 128 LEU A CG    1 
ATOM   935  C  CD1   . LEU A 1 210 ? 49.054 -26.061 -13.280 1.00 41.29  ? 128 LEU A CD1   1 
ATOM   936  C  CD2   . LEU A 1 210 ? 48.889 -26.339 -10.800 1.00 43.23  ? 128 LEU A CD2   1 
ATOM   937  N  N     . VAL A 1 211 ? 54.117 -25.410 -11.024 1.00 43.49  ? 129 VAL A N     1 
ATOM   938  C  CA    . VAL A 1 211 ? 55.543 -25.594 -11.274 1.00 41.52  ? 129 VAL A CA    1 
ATOM   939  C  C     . VAL A 1 211 ? 56.281 -25.900 -9.969  1.00 38.06  ? 129 VAL A C     1 
ATOM   940  O  O     . VAL A 1 211 ? 57.075 -26.834 -9.896  1.00 42.00  ? 129 VAL A O     1 
ATOM   941  C  CB    . VAL A 1 211 ? 56.140 -24.381 -12.003 1.00 39.25  ? 129 VAL A CB    1 
ATOM   942  C  CG1   . VAL A 1 211 ? 57.655 -24.466 -12.124 1.00 40.36  ? 129 VAL A CG1   1 
ATOM   943  C  CG2   . VAL A 1 211 ? 55.517 -24.226 -13.381 1.00 46.39  ? 129 VAL A CG2   1 
ATOM   944  N  N     . MET A 1 212 ? 56.020 -25.128 -8.924  1.00 41.04  ? 130 MET A N     1 
ATOM   945  C  CA    . MET A 1 212 ? 56.767 -25.298 -7.689  1.00 43.07  ? 130 MET A CA    1 
ATOM   946  C  C     . MET A 1 212 ? 56.512 -26.694 -7.122  1.00 43.87  ? 130 MET A C     1 
ATOM   947  O  O     . MET A 1 212 ? 57.416 -27.312 -6.556  1.00 43.74  ? 130 MET A O     1 
ATOM   948  C  CB    . MET A 1 212 ? 56.410 -24.190 -6.691  1.00 44.12  ? 130 MET A CB    1 
ATOM   949  C  CG    . MET A 1 212 ? 56.975 -22.832 -7.083  1.00 45.82  ? 130 MET A CG    1 
ATOM   950  S  SD    . MET A 1 212 ? 56.584 -21.507 -5.924  1.00 46.90  ? 130 MET A SD    1 
ATOM   951  C  CE    . MET A 1 212 ? 54.790 -21.433 -5.965  1.00 43.05  ? 130 MET A CE    1 
ATOM   952  N  N     . GLU A 1 213 ? 55.270 -27.173 -7.278  1.00 48.49  ? 131 GLU A N     1 
ATOM   953  C  CA    . GLU A 1 213 ? 54.845 -28.484 -6.794  1.00 46.26  ? 131 GLU A CA    1 
ATOM   954  C  C     . GLU A 1 213 ? 55.640 -29.588 -7.475  1.00 43.46  ? 131 GLU A C     1 
ATOM   955  O  O     . GLU A 1 213 ? 56.161 -30.486 -6.821  1.00 46.12  ? 131 GLU A O     1 
ATOM   956  C  CB    . GLU A 1 213 ? 53.361 -28.698 -7.093  1.00 45.68  ? 131 GLU A CB    1 
ATOM   957  C  CG    . GLU A 1 213 ? 52.418 -28.025 -6.096  1.00 43.76  ? 131 GLU A CG    1 
ATOM   958  C  CD    . GLU A 1 213 ? 50.982 -28.063 -6.562  1.00 47.54  ? 131 GLU A CD    1 
ATOM   959  O  OE1   . GLU A 1 213 ? 50.725 -28.652 -7.642  1.00 44.74  ? 131 GLU A OE1   1 
ATOM   960  O  OE2   . GLU A 1 213 ? 50.138 -27.491 -5.855  1.00 49.73  ? 131 GLU A OE2   1 
ATOM   961  N  N     . VAL A 1 214 ? 55.708 -29.513 -8.804  1.00 44.46  ? 132 VAL A N     1 
ATOM   962  C  CA    . VAL A 1 214 ? 56.489 -30.463 -9.576  1.00 42.59  ? 132 VAL A CA    1 
ATOM   963  C  C     . VAL A 1 214 ? 57.906 -30.502 -9.013  1.00 43.82  ? 132 VAL A C     1 
ATOM   964  O  O     . VAL A 1 214 ? 58.448 -31.582 -8.823  1.00 49.04  ? 132 VAL A O     1 
ATOM   965  C  CB    . VAL A 1 214 ? 56.462 -30.088 -11.067 1.00 42.80  ? 132 VAL A CB    1 
ATOM   966  C  CG1   . VAL A 1 214 ? 57.573 -30.746 -11.864 1.00 44.17  ? 132 VAL A CG1   1 
ATOM   967  C  CG2   . VAL A 1 214 ? 55.101 -30.367 -11.685 1.00 45.49  ? 132 VAL A CG2   1 
ATOM   968  N  N     . LEU A 1 215 ? 58.498 -29.322 -8.760  1.00 47.56  ? 133 LEU A N     1 
ATOM   969  C  CA    . LEU A 1 215 ? 59.884 -29.220 -8.315  1.00 44.59  ? 133 LEU A CA    1 
ATOM   970  C  C     . LEU A 1 215 ? 60.056 -29.932 -6.968  1.00 43.38  ? 133 LEU A C     1 
ATOM   971  O  O     . LEU A 1 215 ? 61.023 -30.668 -6.752  1.00 40.12  ? 133 LEU A O     1 
ATOM   972  C  CB    . LEU A 1 215 ? 60.337 -27.755 -8.268  1.00 41.74  ? 133 LEU A CB    1 
ATOM   973  C  CG    . LEU A 1 215 ? 60.908 -27.189 -9.583  1.00 43.40  ? 133 LEU A CG    1 
ATOM   974  C  CD1   . LEU A 1 215 ? 61.042 -25.660 -9.578  1.00 43.64  ? 133 LEU A CD1   1 
ATOM   975  C  CD2   . LEU A 1 215 ? 62.268 -27.783 -9.970  1.00 39.91  ? 133 LEU A CD2   1 
ATOM   976  N  N     . GLU A 1 216 ? 59.087 -29.732 -6.074  1.00 40.58  ? 134 GLU A N     1 
ATOM   977  C  CA    . GLU A 1 216 ? 59.150 -30.356 -4.771  1.00 44.69  ? 134 GLU A CA    1 
ATOM   978  C  C     . GLU A 1 216 ? 59.078 -31.880 -4.942  1.00 44.31  ? 134 GLU A C     1 
ATOM   979  O  O     . GLU A 1 216 ? 59.822 -32.618 -4.289  1.00 48.66  ? 134 GLU A O     1 
ATOM   980  C  CB    . GLU A 1 216 ? 58.084 -29.769 -3.844  1.00 43.28  ? 134 GLU A CB    1 
ATOM   981  C  CG    . GLU A 1 216 ? 58.500 -28.494 -3.130  1.00 44.54  ? 134 GLU A CG    1 
ATOM   982  C  CD    . GLU A 1 216 ? 57.468 -27.906 -2.175  1.00 50.95  ? 134 GLU A CD    1 
ATOM   983  O  OE1   . GLU A 1 216 ? 56.285 -28.356 -2.048  1.00 51.52  ? 134 GLU A OE1   1 
ATOM   984  O  OE2   . GLU A 1 216 ? 57.912 -26.944 -1.516  1.00 47.70  ? 134 GLU A OE2   1 
ATOM   985  N  N     . VAL A 1 217 ? 58.177 -32.346 -5.809  1.00 42.19  ? 135 VAL A N     1 
ATOM   986  C  CA    . VAL A 1 217 ? 58.022 -33.770 -6.015  1.00 44.25  ? 135 VAL A CA    1 
ATOM   987  C  C     . VAL A 1 217 ? 59.366 -34.358 -6.473  1.00 49.27  ? 135 VAL A C     1 
ATOM   988  O  O     . VAL A 1 217 ? 59.738 -35.435 -6.024  1.00 49.13  ? 135 VAL A O     1 
ATOM   989  C  CB    . VAL A 1 217 ? 56.893 -34.150 -6.988  1.00 40.61  ? 135 VAL A CB    1 
ATOM   990  C  CG1   . VAL A 1 217 ? 56.996 -35.626 -7.350  1.00 39.73  ? 135 VAL A CG1   1 
ATOM   991  C  CG2   . VAL A 1 217 ? 55.495 -33.857 -6.462  1.00 40.61  ? 135 VAL A CG2   1 
ATOM   992  N  N     . GLU A 1 218 ? 60.122 -33.635 -7.310  1.00 47.34  ? 136 GLU A N     1 
ATOM   993  C  CA    . GLU A 1 218 ? 61.459 -34.050 -7.718  1.00 47.23  ? 136 GLU A CA    1 
ATOM   994  C  C     . GLU A 1 218 ? 62.531 -33.793 -6.657  1.00 47.61  ? 136 GLU A C     1 
ATOM   995  O  O     . GLU A 1 218 ? 63.719 -33.970 -6.935  1.00 49.86  ? 136 GLU A O     1 
ATOM   996  C  CB    . GLU A 1 218 ? 61.913 -33.314 -8.979  1.00 47.03  ? 136 GLU A CB    1 
ATOM   997  C  CG    . GLU A 1 218 ? 60.974 -33.563 -10.155 1.00 50.55  ? 136 GLU A CG    1 
ATOM   998  C  CD    . GLU A 1 218 ? 60.949 -34.984 -10.671 1.00 48.91  ? 136 GLU A CD    1 
ATOM   999  O  OE1   . GLU A 1 218 ? 61.973 -35.412 -11.205 1.00 53.81  ? 136 GLU A OE1   1 
ATOM   1000 O  OE2   . GLU A 1 218 ? 59.907 -35.649 -10.552 1.00 52.76  ? 136 GLU A OE2   1 
ATOM   1001 N  N     . GLY A 1 219 ? 62.145 -33.377 -5.445  1.00 50.36  ? 137 GLY A N     1 
ATOM   1002 C  CA    . GLY A 1 219 ? 63.094 -33.324 -4.339  1.00 52.30  ? 137 GLY A CA    1 
ATOM   1003 C  C     . GLY A 1 219 ? 63.909 -32.033 -4.279  1.00 52.04  ? 137 GLY A C     1 
ATOM   1004 O  O     . GLY A 1 219 ? 64.970 -32.031 -3.659  1.00 46.95  ? 137 GLY A O     1 
ATOM   1005 N  N     . TRP A 1 220 ? 63.382 -30.945 -4.877  1.00 49.79  ? 138 TRP A N     1 
ATOM   1006 C  CA    . TRP A 1 220 ? 63.996 -29.626 -4.801  1.00 51.46  ? 138 TRP A CA    1 
ATOM   1007 C  C     . TRP A 1 220 ? 63.498 -28.915 -3.556  1.00 50.46  ? 138 TRP A C     1 
ATOM   1008 O  O     . TRP A 1 220 ? 62.349 -29.144 -3.164  1.00 47.38  ? 138 TRP A O     1 
ATOM   1009 C  CB    . TRP A 1 220 ? 63.625 -28.756 -6.008  1.00 49.89  ? 138 TRP A CB    1 
ATOM   1010 C  CG    . TRP A 1 220 ? 64.299 -29.123 -7.295  1.00 48.20  ? 138 TRP A CG    1 
ATOM   1011 C  CD1   . TRP A 1 220 ? 64.016 -30.188 -8.092  1.00 47.04  ? 138 TRP A CD1   1 
ATOM   1012 C  CD2   . TRP A 1 220 ? 65.336 -28.383 -7.964  1.00 43.74  ? 138 TRP A CD2   1 
ATOM   1013 N  NE1   . TRP A 1 220 ? 64.824 -30.176 -9.192  1.00 42.77  ? 138 TRP A NE1   1 
ATOM   1014 C  CE2   . TRP A 1 220 ? 65.637 -29.080 -9.144  1.00 42.25  ? 138 TRP A CE2   1 
ATOM   1015 C  CE3   . TRP A 1 220 ? 66.037 -27.214 -7.672  1.00 46.07  ? 138 TRP A CE3   1 
ATOM   1016 C  CZ2   . TRP A 1 220 ? 66.621 -28.661 -10.027 1.00 42.78  ? 138 TRP A CZ2   1 
ATOM   1017 C  CZ3   . TRP A 1 220 ? 66.982 -26.776 -8.563  1.00 43.66  ? 138 TRP A CZ3   1 
ATOM   1018 C  CH2   . TRP A 1 220 ? 67.281 -27.502 -9.711  1.00 44.78  ? 138 TRP A CH2   1 
ATOM   1019 N  N     . ARG A 1 221 ? 64.334 -28.023 -2.996  1.00 49.54  ? 139 ARG A N     1 
ATOM   1020 C  CA    . ARG A 1 221 ? 63.818 -27.047 -2.049  1.00 56.22  ? 139 ARG A CA    1 
ATOM   1021 C  C     . ARG A 1 221 ? 63.361 -25.880 -2.911  1.00 52.20  ? 139 ARG A C     1 
ATOM   1022 O  O     . ARG A 1 221 ? 64.016 -25.582 -3.904  1.00 46.14  ? 139 ARG A O     1 
ATOM   1023 C  CB    . ARG A 1 221 ? 64.763 -26.655 -0.904  1.00 63.65  ? 139 ARG A CB    1 
ATOM   1024 C  CG    . ARG A 1 221 ? 63.947 -26.503 0.378   1.00 82.58  ? 139 ARG A CG    1 
ATOM   1025 C  CD    . ARG A 1 221 ? 64.672 -26.197 1.698   1.00 99.84  ? 139 ARG A CD    1 
ATOM   1026 N  NE    . ARG A 1 221 ? 65.660 -27.163 2.214   1.00 105.93 ? 139 ARG A NE    1 
ATOM   1027 C  CZ    . ARG A 1 221 ? 65.524 -28.482 2.426   1.00 104.54 ? 139 ARG A CZ    1 
ATOM   1028 N  NH1   . ARG A 1 221 ? 64.492 -29.151 1.938   1.00 99.64  ? 139 ARG A NH1   1 
ATOM   1029 N  NH2   . ARG A 1 221 ? 66.458 -29.148 3.092   1.00 98.78  ? 139 ARG A NH2   1 
ATOM   1030 N  N     . VAL A 1 222 ? 62.203 -25.288 -2.591  1.00 49.87  ? 140 VAL A N     1 
ATOM   1031 C  CA    . VAL A 1 222 ? 61.665 -24.191 -3.390  1.00 47.31  ? 140 VAL A CA    1 
ATOM   1032 C  C     . VAL A 1 222 ? 61.517 -22.937 -2.534  1.00 42.62  ? 140 VAL A C     1 
ATOM   1033 O  O     . VAL A 1 222 ? 60.976 -23.002 -1.442  1.00 45.50  ? 140 VAL A O     1 
ATOM   1034 C  CB    . VAL A 1 222 ? 60.315 -24.581 -4.022  1.00 47.44  ? 140 VAL A CB    1 
ATOM   1035 C  CG1   . VAL A 1 222 ? 59.560 -23.373 -4.575  1.00 50.92  ? 140 VAL A CG1   1 
ATOM   1036 C  CG2   . VAL A 1 222 ? 60.498 -25.628 -5.100  1.00 42.41  ? 140 VAL A CG2   1 
ATOM   1037 N  N     . LEU A 1 223 ? 61.980 -21.797 -3.052  1.00 46.90  ? 141 LEU A N     1 
ATOM   1038 C  CA    . LEU A 1 223 ? 61.706 -20.489 -2.461  1.00 48.22  ? 141 LEU A CA    1 
ATOM   1039 C  C     . LEU A 1 223 ? 60.758 -19.763 -3.397  1.00 46.02  ? 141 LEU A C     1 
ATOM   1040 O  O     . LEU A 1 223 ? 61.126 -19.495 -4.538  1.00 51.44  ? 141 LEU A O     1 
ATOM   1041 C  CB    . LEU A 1 223 ? 62.967 -19.645 -2.238  1.00 45.69  ? 141 LEU A CB    1 
ATOM   1042 C  CG    . LEU A 1 223 ? 63.845 -20.075 -1.056  1.00 56.39  ? 141 LEU A CG    1 
ATOM   1043 C  CD1   . LEU A 1 223 ? 65.146 -19.309 -0.947  1.00 58.13  ? 141 LEU A CD1   1 
ATOM   1044 C  CD2   . LEU A 1 223 ? 63.070 -19.943 0.241   1.00 60.99  ? 141 LEU A CD2   1 
ATOM   1045 N  N     . SER A 1 224 ? 59.552 -19.487 -2.904  1.00 41.30  ? 142 SER A N     1 
ATOM   1046 C  CA    . SER A 1 224 ? 58.539 -18.748 -3.634  1.00 41.28  ? 142 SER A CA    1 
ATOM   1047 C  C     . SER A 1 224 ? 58.626 -17.260 -3.305  1.00 40.71  ? 142 SER A C     1 
ATOM   1048 O  O     . SER A 1 224 ? 58.404 -16.862 -2.159  1.00 39.71  ? 142 SER A O     1 
ATOM   1049 C  CB    . SER A 1 224 ? 57.155 -19.262 -3.315  1.00 41.47  ? 142 SER A CB    1 
ATOM   1050 O  OG    . SER A 1 224 ? 56.195 -18.672 -4.183  1.00 47.47  ? 142 SER A OG    1 
ATOM   1051 N  N     . LEU A 1 225 ? 58.911 -16.458 -4.334  1.00 37.31  ? 143 LEU A N     1 
ATOM   1052 C  CA    . LEU A 1 225 ? 58.669 -15.025 -4.292  1.00 38.29  ? 143 LEU A CA    1 
ATOM   1053 C  C     . LEU A 1 225 ? 57.231 -14.688 -4.667  1.00 41.01  ? 143 LEU A C     1 
ATOM   1054 O  O     . LEU A 1 225 ? 56.749 -13.599 -4.353  1.00 42.95  ? 143 LEU A O     1 
ATOM   1055 C  CB    . LEU A 1 225 ? 59.649 -14.292 -5.198  1.00 39.60  ? 143 LEU A CB    1 
ATOM   1056 C  CG    . LEU A 1 225 ? 61.096 -14.314 -4.699  1.00 37.17  ? 143 LEU A CG    1 
ATOM   1057 C  CD1   . LEU A 1 225 ? 62.041 -13.867 -5.781  1.00 42.21  ? 143 LEU A CD1   1 
ATOM   1058 C  CD2   . LEU A 1 225 ? 61.197 -13.436 -3.463  1.00 39.63  ? 143 LEU A CD2   1 
ATOM   1059 N  N     . GLY A 1 226 ? 56.527 -15.656 -5.256  1.00 47.28  ? 144 GLY A N     1 
ATOM   1060 C  CA    . GLY A 1 226 ? 55.131 -15.460 -5.576  1.00 44.06  ? 144 GLY A CA    1 
ATOM   1061 C  C     . GLY A 1 226 ? 55.038 -14.562 -6.798  1.00 45.01  ? 144 GLY A C     1 
ATOM   1062 O  O     . GLY A 1 226 ? 56.050 -14.323 -7.469  1.00 47.58  ? 144 GLY A O     1 
ATOM   1063 N  N     . PRO A 1 227 ? 53.837 -14.032 -7.092  1.00 37.86  ? 145 PRO A N     1 
ATOM   1064 C  CA    . PRO A 1 227 ? 53.622 -13.191 -8.279  1.00 38.35  ? 145 PRO A CA    1 
ATOM   1065 C  C     . PRO A 1 227 ? 54.043 -11.757 -7.994  1.00 42.51  ? 145 PRO A C     1 
ATOM   1066 O  O     . PRO A 1 227 ? 54.286 -11.415 -6.821  1.00 43.57  ? 145 PRO A O     1 
ATOM   1067 C  CB    . PRO A 1 227 ? 52.103 -13.262 -8.464  1.00 40.70  ? 145 PRO A CB    1 
ATOM   1068 C  CG    . PRO A 1 227 ? 51.564 -13.386 -7.018  1.00 35.76  ? 145 PRO A CG    1 
ATOM   1069 C  CD    . PRO A 1 227 ? 52.637 -14.171 -6.246  1.00 36.91  ? 145 PRO A CD    1 
ATOM   1070 N  N     . ASN A 1 228 ? 54.070 -10.937 -9.060  1.00 44.37  ? 146 ASN A N     1 
ATOM   1071 C  CA    . ASN A 1 228 ? 54.262 -9.494  -8.949  1.00 44.47  ? 146 ASN A CA    1 
ATOM   1072 C  C     . ASN A 1 228 ? 55.627 -9.206  -8.307  1.00 43.80  ? 146 ASN A C     1 
ATOM   1073 O  O     . ASN A 1 228 ? 55.760 -8.470  -7.325  1.00 39.68  ? 146 ASN A O     1 
ATOM   1074 C  CB    . ASN A 1 228 ? 53.073 -8.888  -8.218  1.00 47.35  ? 146 ASN A CB    1 
ATOM   1075 C  CG    . ASN A 1 228 ? 53.135 -7.385  -8.055  1.00 46.89  ? 146 ASN A CG    1 
ATOM   1076 O  OD1   . ASN A 1 228 ? 53.634 -6.652  -8.920  1.00 45.56  ? 146 ASN A OD1   1 
ATOM   1077 N  ND2   . ASN A 1 228 ? 52.506 -6.912  -6.996  1.00 44.22  ? 146 ASN A ND2   1 
ATOM   1078 N  N     . THR A 1 229 ? 56.659 -9.838  -8.862  1.00 40.80  ? 147 THR A N     1 
ATOM   1079 C  CA    . THR A 1 229 ? 57.990 -9.729  -8.294  1.00 44.41  ? 147 THR A CA    1 
ATOM   1080 C  C     . THR A 1 229 ? 58.898 -8.996  -9.283  1.00 43.98  ? 147 THR A C     1 
ATOM   1081 O  O     . THR A 1 229 ? 59.028 -9.406  -10.441 1.00 49.98  ? 147 THR A O     1 
ATOM   1082 C  CB    . THR A 1 229 ? 58.522 -11.121 -7.968  1.00 44.70  ? 147 THR A CB    1 
ATOM   1083 O  OG1   . THR A 1 229 ? 57.580 -11.734 -7.082  1.00 37.84  ? 147 THR A OG1   1 
ATOM   1084 C  CG2   . THR A 1 229 ? 59.940 -11.021 -7.433  1.00 40.47  ? 147 THR A CG2   1 
ATOM   1085 N  N     . PRO A 1 230 ? 59.487 -7.844  -8.893  1.00 41.65  ? 148 PRO A N     1 
ATOM   1086 C  CA    . PRO A 1 230 ? 60.433 -7.133  -9.761  1.00 39.19  ? 148 PRO A CA    1 
ATOM   1087 C  C     . PRO A 1 230 ? 61.672 -7.975  -9.975  1.00 39.99  ? 148 PRO A C     1 
ATOM   1088 O  O     . PRO A 1 230 ? 62.043 -8.705  -9.064  1.00 45.89  ? 148 PRO A O     1 
ATOM   1089 C  CB    . PRO A 1 230 ? 60.744 -5.877  -8.955  1.00 42.98  ? 148 PRO A CB    1 
ATOM   1090 C  CG    . PRO A 1 230 ? 59.528 -5.700  -8.032  1.00 42.29  ? 148 PRO A CG    1 
ATOM   1091 C  CD    . PRO A 1 230 ? 59.183 -7.118  -7.647  1.00 43.47  ? 148 PRO A CD    1 
ATOM   1092 N  N     . LEU A 1 231 ? 62.354 -7.814  -11.118 1.00 42.00  ? 149 LEU A N     1 
ATOM   1093 C  CA    . LEU A 1 231 ? 63.588 -8.547  -11.382 1.00 43.07  ? 149 LEU A CA    1 
ATOM   1094 C  C     . LEU A 1 231 ? 64.701 -8.248  -10.373 1.00 44.15  ? 149 LEU A C     1 
ATOM   1095 O  O     . LEU A 1 231 ? 65.518 -9.129  -10.070 1.00 44.98  ? 149 LEU A O     1 
ATOM   1096 C  CB    . LEU A 1 231 ? 64.114 -8.251  -12.774 1.00 46.56  ? 149 LEU A CB    1 
ATOM   1097 C  CG    . LEU A 1 231 ? 63.230 -8.730  -13.919 1.00 51.33  ? 149 LEU A CG    1 
ATOM   1098 C  CD1   . LEU A 1 231 ? 63.988 -8.447  -15.217 1.00 59.41  ? 149 LEU A CD1   1 
ATOM   1099 C  CD2   . LEU A 1 231 ? 62.849 -10.181 -13.792 1.00 48.18  ? 149 LEU A CD2   1 
ATOM   1100 N  N     . PHE A 1 232 ? 64.786 -7.000  -9.904  1.00 37.37  ? 150 PHE A N     1 
ATOM   1101 C  CA    . PHE A 1 232 ? 65.776 -6.663  -8.900  1.00 38.64  ? 150 PHE A CA    1 
ATOM   1102 C  C     . PHE A 1 232 ? 65.511 -7.478  -7.639  1.00 42.27  ? 150 PHE A C     1 
ATOM   1103 O  O     . PHE A 1 232 ? 66.421 -7.696  -6.839  1.00 42.32  ? 150 PHE A O     1 
ATOM   1104 C  CB    . PHE A 1 232 ? 65.917 -5.160  -8.597  1.00 40.02  ? 150 PHE A CB    1 
ATOM   1105 C  CG    . PHE A 1 232 ? 64.705 -4.376  -8.139  1.00 41.26  ? 150 PHE A CG    1 
ATOM   1106 C  CD1   . PHE A 1 232 ? 64.348 -4.345  -6.801  1.00 42.43  ? 150 PHE A CD1   1 
ATOM   1107 C  CD2   . PHE A 1 232 ? 63.960 -3.634  -9.045  1.00 48.19  ? 150 PHE A CD2   1 
ATOM   1108 C  CE1   . PHE A 1 232 ? 63.238 -3.647  -6.391  1.00 47.17  ? 150 PHE A CE1   1 
ATOM   1109 C  CE2   . PHE A 1 232 ? 62.856 -2.909  -8.626  1.00 43.34  ? 150 PHE A CE2   1 
ATOM   1110 C  CZ    . PHE A 1 232 ? 62.516 -2.900  -7.305  1.00 51.80  ? 150 PHE A CZ    1 
ATOM   1111 N  N     . SER A 1 233 ? 64.260 -7.921  -7.453  1.00 42.65  ? 151 SER A N     1 
ATOM   1112 C  CA    . SER A 1 233 ? 63.913 -8.620  -6.234  1.00 42.51  ? 151 SER A CA    1 
ATOM   1113 C  C     . SER A 1 233 ? 64.355 -10.070 -6.391  1.00 45.91  ? 151 SER A C     1 
ATOM   1114 O  O     . SER A 1 233 ? 64.860 -10.700 -5.456  1.00 47.60  ? 151 SER A O     1 
ATOM   1115 C  CB    . SER A 1 233 ? 62.439 -8.439  -5.926  1.00 41.02  ? 151 SER A CB    1 
ATOM   1116 O  OG    . SER A 1 233 ? 62.156 -7.052  -5.756  1.00 41.28  ? 151 SER A OG    1 
ATOM   1117 N  N     . PHE A 1 234 ? 64.212 -10.562 -7.625  1.00 45.20  ? 152 PHE A N     1 
ATOM   1118 C  CA    . PHE A 1 234 ? 64.799 -11.833 -8.022  1.00 46.74  ? 152 PHE A CA    1 
ATOM   1119 C  C     . PHE A 1 234 ? 66.315 -11.807 -7.771  1.00 47.80  ? 152 PHE A C     1 
ATOM   1120 O  O     . PHE A 1 234 ? 66.854 -12.667 -7.068  1.00 40.21  ? 152 PHE A O     1 
ATOM   1121 C  CB    . PHE A 1 234 ? 64.372 -12.092 -9.472  1.00 42.94  ? 152 PHE A CB    1 
ATOM   1122 C  CG    . PHE A 1 234 ? 63.039 -12.798 -9.725  1.00 43.86  ? 152 PHE A CG    1 
ATOM   1123 C  CD1   . PHE A 1 234 ? 62.942 -14.191 -9.690  1.00 48.55  ? 152 PHE A CD1   1 
ATOM   1124 C  CD2   . PHE A 1 234 ? 61.909 -12.085 -10.106 1.00 44.79  ? 152 PHE A CD2   1 
ATOM   1125 C  CE1   . PHE A 1 234 ? 61.755 -14.844 -10.006 1.00 43.01  ? 152 PHE A CE1   1 
ATOM   1126 C  CE2   . PHE A 1 234 ? 60.720 -12.737 -10.397 1.00 47.33  ? 152 PHE A CE2   1 
ATOM   1127 C  CZ    . PHE A 1 234 ? 60.650 -14.122 -10.367 1.00 44.58  ? 152 PHE A CZ    1 
ATOM   1128 N  N     . ALA A 1 235 ? 66.994 -10.786 -8.321  1.00 49.26  ? 153 ALA A N     1 
ATOM   1129 C  CA    . ALA A 1 235 ? 68.437 -10.638 -8.172  1.00 49.37  ? 153 ALA A CA    1 
ATOM   1130 C  C     . ALA A 1 235 ? 68.834 -10.575 -6.690  1.00 46.61  ? 153 ALA A C     1 
ATOM   1131 O  O     . ALA A 1 235 ? 69.745 -11.271 -6.249  1.00 46.05  ? 153 ALA A O     1 
ATOM   1132 C  CB    . ALA A 1 235 ? 68.916 -9.439  -8.967  1.00 42.96  ? 153 ALA A CB    1 
ATOM   1133 N  N     . ASP A 1 236 ? 68.116 -9.807  -5.879  1.00 46.31  ? 154 ASP A N     1 
ATOM   1134 C  CA    . ASP A 1 236 ? 68.466 -9.756  -4.467  1.00 54.35  ? 154 ASP A CA    1 
ATOM   1135 C  C     . ASP A 1 236 ? 68.455 -11.154 -3.858  1.00 49.56  ? 154 ASP A C     1 
ATOM   1136 O  O     . ASP A 1 236 ? 69.344 -11.499 -3.090  1.00 55.13  ? 154 ASP A O     1 
ATOM   1137 C  CB    . ASP A 1 236 ? 67.557 -8.853  -3.653  1.00 58.45  ? 154 ASP A CB    1 
ATOM   1138 C  CG    . ASP A 1 236 ? 67.677 -7.372  -3.980  1.00 62.42  ? 154 ASP A CG    1 
ATOM   1139 O  OD1   . ASP A 1 236 ? 68.831 -6.946  -4.173  1.00 58.73  ? 154 ASP A OD1   1 
ATOM   1140 O  OD2   . ASP A 1 236 ? 66.616 -6.681  -4.044  1.00 58.91  ? 154 ASP A OD2   1 
ATOM   1141 N  N     . ALA A 1 237 ? 67.442 -11.947 -4.202  1.00 47.57  ? 155 ALA A N     1 
ATOM   1142 C  CA    . ALA A 1 237 ? 67.222 -13.224 -3.542  1.00 47.60  ? 155 ALA A CA    1 
ATOM   1143 C  C     . ALA A 1 237 ? 68.227 -14.259 -4.052  1.00 45.02  ? 155 ALA A C     1 
ATOM   1144 O  O     . ALA A 1 237 ? 68.585 -15.179 -3.315  1.00 46.78  ? 155 ALA A O     1 
ATOM   1145 C  CB    . ALA A 1 237 ? 65.789 -13.679 -3.748  1.00 44.45  ? 155 ALA A CB    1 
ATOM   1146 N  N     . VAL A 1 238 ? 68.691 -14.088 -5.300  1.00 41.88  ? 156 VAL A N     1 
ATOM   1147 C  CA    . VAL A 1 238 ? 69.760 -14.914 -5.833  1.00 44.20  ? 156 VAL A CA    1 
ATOM   1148 C  C     . VAL A 1 238 ? 71.043 -14.648 -5.034  1.00 43.40  ? 156 VAL A C     1 
ATOM   1149 O  O     . VAL A 1 238 ? 71.722 -15.601 -4.675  1.00 40.17  ? 156 VAL A O     1 
ATOM   1150 C  CB    . VAL A 1 238 ? 69.981 -14.750 -7.354  1.00 44.90  ? 156 VAL A CB    1 
ATOM   1151 C  CG1   . VAL A 1 238 ? 71.226 -15.478 -7.847  1.00 45.04  ? 156 VAL A CG1   1 
ATOM   1152 C  CG2   . VAL A 1 238 ? 68.786 -15.236 -8.161  1.00 44.20  ? 156 VAL A CG2   1 
ATOM   1153 N  N     . ARG A 1 239 ? 71.374 -13.379 -4.741  1.00 44.59  ? 157 ARG A N     1 
ATOM   1154 C  CA    . ARG A 1 239 ? 72.557 -13.087 -3.945  1.00 48.94  ? 157 ARG A CA    1 
ATOM   1155 C  C     . ARG A 1 239 ? 72.433 -13.716 -2.553  1.00 53.71  ? 157 ARG A C     1 
ATOM   1156 O  O     . ARG A 1 239 ? 73.397 -14.269 -2.045  1.00 59.09  ? 157 ARG A O     1 
ATOM   1157 C  CB    . ARG A 1 239 ? 72.854 -11.601 -3.751  1.00 45.24  ? 157 ARG A CB    1 
ATOM   1158 C  CG    . ARG A 1 239 ? 73.360 -10.877 -4.984  1.00 48.96  ? 157 ARG A CG    1 
ATOM   1159 C  CD    . ARG A 1 239 ? 73.486 -9.360  -4.718  1.00 52.61  ? 157 ARG A CD    1 
ATOM   1160 N  NE    . ARG A 1 239 ? 73.385 -8.722  -6.041  1.00 62.63  ? 157 ARG A NE    1 
ATOM   1161 C  CZ    . ARG A 1 239 ? 72.299 -8.106  -6.521  1.00 62.81  ? 157 ARG A CZ    1 
ATOM   1162 N  NH1   . ARG A 1 239 ? 71.349 -7.717  -5.680  1.00 63.73  ? 157 ARG A NH1   1 
ATOM   1163 N  NH2   . ARG A 1 239 ? 72.178 -7.858  -7.825  1.00 58.38  ? 157 ARG A NH2   1 
ATOM   1164 N  N     . ARG A 1 240 ? 71.242 -13.670 -1.959  1.00 49.79  ? 158 ARG A N     1 
ATOM   1165 C  CA    . ARG A 1 240 ? 71.051 -14.081 -0.580  1.00 50.73  ? 158 ARG A CA    1 
ATOM   1166 C  C     . ARG A 1 240 ? 71.118 -15.601 -0.426  1.00 53.28  ? 158 ARG A C     1 
ATOM   1167 O  O     . ARG A 1 240 ? 71.546 -16.061 0.629   1.00 51.04  ? 158 ARG A O     1 
ATOM   1168 C  CB    . ARG A 1 240 ? 69.704 -13.545 -0.077  1.00 52.40  ? 158 ARG A CB    1 
ATOM   1169 C  CG    . ARG A 1 240 ? 69.233 -14.102 1.261   1.00 57.65  ? 158 ARG A CG    1 
ATOM   1170 C  CD    . ARG A 1 240 ? 70.078 -13.698 2.471   1.00 59.11  ? 158 ARG A CD    1 
ATOM   1171 N  NE    . ARG A 1 240 ? 69.575 -14.402 3.662   1.00 61.60  ? 158 ARG A NE    1 
ATOM   1172 C  CZ    . ARG A 1 240 ? 69.732 -15.702 3.898   1.00 62.24  ? 158 ARG A CZ    1 
ATOM   1173 N  NH1   . ARG A 1 240 ? 70.591 -16.412 3.197   1.00 68.71  ? 158 ARG A NH1   1 
ATOM   1174 N  NH2   . ARG A 1 240 ? 69.051 -16.312 4.843   1.00 60.93  ? 158 ARG A NH2   1 
ATOM   1175 N  N     . PHE A 1 241 ? 70.650 -16.372 -1.429  1.00 48.21  ? 159 PHE A N     1 
ATOM   1176 C  CA    . PHE A 1 241 ? 70.387 -17.795 -1.253  1.00 40.64  ? 159 PHE A CA    1 
ATOM   1177 C  C     . PHE A 1 241 ? 71.227 -18.653 -2.199  1.00 43.62  ? 159 PHE A C     1 
ATOM   1178 O  O     . PHE A 1 241 ? 71.304 -19.852 -2.031  1.00 48.28  ? 159 PHE A O     1 
ATOM   1179 C  CB    . PHE A 1 241 ? 68.902 -18.081 -1.491  1.00 46.75  ? 159 PHE A CB    1 
ATOM   1180 C  CG    . PHE A 1 241 ? 67.965 -17.489 -0.437  1.00 52.44  ? 159 PHE A CG    1 
ATOM   1181 C  CD1   . PHE A 1 241 ? 67.905 -18.014 0.859   1.00 45.42  ? 159 PHE A CD1   1 
ATOM   1182 C  CD2   . PHE A 1 241 ? 67.136 -16.415 -0.743  1.00 45.92  ? 159 PHE A CD2   1 
ATOM   1183 C  CE1   . PHE A 1 241 ? 67.077 -17.459 1.820   1.00 44.09  ? 159 PHE A CE1   1 
ATOM   1184 C  CE2   . PHE A 1 241 ? 66.321 -15.863 0.230   1.00 51.12  ? 159 PHE A CE2   1 
ATOM   1185 C  CZ    . PHE A 1 241 ? 66.290 -16.387 1.502   1.00 52.09  ? 159 PHE A CZ    1 
ATOM   1186 N  N     . SER A 1 242 ? 71.868 -18.044 -3.188  1.00 49.16  ? 160 SER A N     1 
ATOM   1187 C  CA    . SER A 1 242 ? 72.579 -18.732 -4.262  1.00 54.53  ? 160 SER A CA    1 
ATOM   1188 C  C     . SER A 1 242 ? 71.829 -19.992 -4.676  1.00 46.15  ? 160 SER A C     1 
ATOM   1189 O  O     . SER A 1 242 ? 72.296 -21.106 -4.566  1.00 49.31  ? 160 SER A O     1 
ATOM   1190 C  CB    . SER A 1 242 ? 74.060 -18.974 -3.969  1.00 50.16  ? 160 SER A CB    1 
ATOM   1191 O  OG    . SER A 1 242 ? 74.180 -19.542 -2.685  1.00 63.02  ? 160 SER A OG    1 
ATOM   1192 N  N     . PRO A 1 243 ? 70.659 -19.841 -5.305  1.00 50.17  ? 161 PRO A N     1 
ATOM   1193 C  CA    . PRO A 1 243 ? 69.934 -20.994 -5.829  1.00 45.89  ? 161 PRO A CA    1 
ATOM   1194 C  C     . PRO A 1 243 ? 70.566 -21.543 -7.104  1.00 42.32  ? 161 PRO A C     1 
ATOM   1195 O  O     . PRO A 1 243 ? 71.363 -20.877 -7.751  1.00 43.49  ? 161 PRO A O     1 
ATOM   1196 C  CB    . PRO A 1 243 ? 68.583 -20.347 -6.099  1.00 47.33  ? 161 PRO A CB    1 
ATOM   1197 C  CG    . PRO A 1 243 ? 68.949 -18.953 -6.617  1.00 45.46  ? 161 PRO A CG    1 
ATOM   1198 C  CD    . PRO A 1 243 ? 70.032 -18.549 -5.627  1.00 49.03  ? 161 PRO A CD    1 
ATOM   1199 N  N     . GLN A 1 244 ? 70.120 -22.733 -7.493  1.00 45.68  ? 162 GLN A N     1 
ATOM   1200 C  CA    . GLN A 1 244 ? 70.626 -23.432 -8.658  1.00 44.01  ? 162 GLN A CA    1 
ATOM   1201 C  C     . GLN A 1 244 ? 69.753 -23.157 -9.873  1.00 44.06  ? 162 GLN A C     1 
ATOM   1202 O  O     . GLN A 1 244 ? 70.185 -23.330 -11.017 1.00 44.27  ? 162 GLN A O     1 
ATOM   1203 C  CB    . GLN A 1 244 ? 70.685 -24.921 -8.316  1.00 42.69  ? 162 GLN A CB    1 
ATOM   1204 C  CG    . GLN A 1 244 ? 71.894 -25.313 -7.460  1.00 38.15  ? 162 GLN A CG    1 
ATOM   1205 C  CD    . GLN A 1 244 ? 71.856 -24.742 -6.060  1.00 42.84  ? 162 GLN A CD    1 
ATOM   1206 O  OE1   . GLN A 1 244 ? 70.998 -25.035 -5.208  1.00 41.95  ? 162 GLN A OE1   1 
ATOM   1207 N  NE2   . GLN A 1 244 ? 72.802 -23.860 -5.825  1.00 45.69  ? 162 GLN A NE2   1 
ATOM   1208 N  N     . LEU A 1 245 ? 68.513 -22.739 -9.602  1.00 51.74  ? 163 LEU A N     1 
ATOM   1209 C  CA    . LEU A 1 245 ? 67.492 -22.585 -10.625 1.00 46.58  ? 163 LEU A CA    1 
ATOM   1210 C  C     . LEU A 1 245 ? 66.584 -21.426 -10.245 1.00 47.94  ? 163 LEU A C     1 
ATOM   1211 O  O     . LEU A 1 245 ? 66.196 -21.305 -9.089  1.00 51.90  ? 163 LEU A O     1 
ATOM   1212 C  CB    . LEU A 1 245 ? 66.714 -23.892 -10.702 1.00 44.72  ? 163 LEU A CB    1 
ATOM   1213 C  CG    . LEU A 1 245 ? 65.449 -23.890 -11.557 1.00 48.10  ? 163 LEU A CG    1 
ATOM   1214 C  CD1   . LEU A 1 245 ? 65.823 -23.679 -13.019 1.00 53.41  ? 163 LEU A CD1   1 
ATOM   1215 C  CD2   . LEU A 1 245 ? 64.667 -25.190 -11.363 1.00 44.37  ? 163 LEU A CD2   1 
ATOM   1216 N  N     . VAL A 1 246 ? 66.303 -20.577 -11.232 1.00 44.52  ? 164 VAL A N     1 
ATOM   1217 C  CA    . VAL A 1 246 ? 65.292 -19.545 -11.156 1.00 45.64  ? 164 VAL A CA    1 
ATOM   1218 C  C     . VAL A 1 246 ? 64.206 -19.860 -12.184 1.00 42.03  ? 164 VAL A C     1 
ATOM   1219 O  O     . VAL A 1 246 ? 64.478 -19.951 -13.373 1.00 41.87  ? 164 VAL A O     1 
ATOM   1220 C  CB    . VAL A 1 246 ? 65.882 -18.153 -11.456 1.00 45.19  ? 164 VAL A CB    1 
ATOM   1221 C  CG1   . VAL A 1 246 ? 64.807 -17.088 -11.323 1.00 44.36  ? 164 VAL A CG1   1 
ATOM   1222 C  CG2   . VAL A 1 246 ? 67.057 -17.821 -10.559 1.00 40.84  ? 164 VAL A CG2   1 
ATOM   1223 N  N     . CYS A 1 247 ? 62.964 -19.961 -11.728 1.00 40.97  ? 165 CYS A N     1 
ATOM   1224 C  CA    . CYS A 1 247 ? 61.834 -20.157 -12.622 1.00 43.50  ? 165 CYS A CA    1 
ATOM   1225 C  C     . CYS A 1 247 ? 60.955 -18.912 -12.629 1.00 45.41  ? 165 CYS A C     1 
ATOM   1226 O  O     . CYS A 1 247 ? 60.557 -18.405 -11.579 1.00 42.00  ? 165 CYS A O     1 
ATOM   1227 C  CB    . CYS A 1 247 ? 60.948 -21.324 -12.186 1.00 41.84  ? 165 CYS A CB    1 
ATOM   1228 S  SG    . CYS A 1 247 ? 61.805 -22.920 -12.174 1.00 44.41  ? 165 CYS A SG    1 
ATOM   1229 N  N     . ILE A 1 248 ? 60.571 -18.497 -13.830 1.00 46.76  ? 166 ILE A N     1 
ATOM   1230 C  CA    . ILE A 1 248 ? 59.638 -17.405 -13.979 1.00 42.95  ? 166 ILE A CA    1 
ATOM   1231 C  C     . ILE A 1 248 ? 58.452 -17.857 -14.808 1.00 38.56  ? 166 ILE A C     1 
ATOM   1232 O  O     . ILE A 1 248 ? 58.618 -18.266 -15.952 1.00 37.59  ? 166 ILE A O     1 
ATOM   1233 C  CB    . ILE A 1 248 ? 60.325 -16.212 -14.656 1.00 47.01  ? 166 ILE A CB    1 
ATOM   1234 C  CG1   . ILE A 1 248 ? 61.592 -15.778 -13.915 1.00 43.88  ? 166 ILE A CG1   1 
ATOM   1235 C  CG2   . ILE A 1 248 ? 59.311 -15.077 -14.796 1.00 45.35  ? 166 ILE A CG2   1 
ATOM   1236 C  CD1   . ILE A 1 248 ? 62.425 -14.780 -14.698 1.00 46.24  ? 166 ILE A CD1   1 
ATOM   1237 N  N     . SER A 1 249 ? 57.269 -17.727 -14.217 1.00 41.09  ? 167 SER A N     1 
ATOM   1238 C  CA    . SER A 1 249 ? 56.006 -17.822 -14.919 1.00 42.44  ? 167 SER A CA    1 
ATOM   1239 C  C     . SER A 1 249 ? 55.536 -16.415 -15.268 1.00 46.54  ? 167 SER A C     1 
ATOM   1240 O  O     . SER A 1 249 ? 55.475 -15.556 -14.391 1.00 45.87  ? 167 SER A O     1 
ATOM   1241 C  CB    . SER A 1 249 ? 54.995 -18.509 -14.064 1.00 42.44  ? 167 SER A CB    1 
ATOM   1242 O  OG    . SER A 1 249 ? 53.758 -18.657 -14.739 1.00 35.26  ? 167 SER A OG    1 
ATOM   1243 N  N     . ALA A 1 250 ? 55.191 -16.199 -16.545 1.00 45.97  ? 168 ALA A N     1 
ATOM   1244 C  CA    . ALA A 1 250 ? 54.746 -14.899 -17.009 1.00 41.90  ? 168 ALA A CA    1 
ATOM   1245 C  C     . ALA A 1 250 ? 53.568 -15.060 -17.968 1.00 43.35  ? 168 ALA A C     1 
ATOM   1246 O  O     . ALA A 1 250 ? 53.698 -15.650 -19.048 1.00 37.85  ? 168 ALA A O     1 
ATOM   1247 C  CB    . ALA A 1 250 ? 55.888 -14.158 -17.655 1.00 44.36  ? 168 ALA A CB    1 
ATOM   1248 N  N     . THR A 1 251 ? 52.426 -14.508 -17.534 1.00 44.17  ? 169 THR A N     1 
ATOM   1249 C  CA    . THR A 1 251 ? 51.204 -14.416 -18.320 1.00 46.10  ? 169 THR A CA    1 
ATOM   1250 C  C     . THR A 1 251 ? 51.056 -13.026 -18.938 1.00 44.68  ? 169 THR A C     1 
ATOM   1251 O  O     . THR A 1 251 ? 50.610 -12.913 -20.073 1.00 49.10  ? 169 THR A O     1 
ATOM   1252 C  CB    . THR A 1 251 ? 49.996 -14.715 -17.432 1.00 43.06  ? 169 THR A CB    1 
ATOM   1253 O  OG1   . THR A 1 251 ? 50.277 -15.988 -16.876 1.00 36.97  ? 169 THR A OG1   1 
ATOM   1254 C  CG2   . THR A 1 251 ? 48.707 -14.708 -18.228 1.00 42.68  ? 169 THR A CG2   1 
ATOM   1255 N  N     . ILE A 1 252 ? 51.371 -11.986 -18.158 1.00 44.57  ? 170 ILE A N     1 
ATOM   1256 C  CA    . ILE A 1 252 ? 51.157 -10.613 -18.562 1.00 52.54  ? 170 ILE A CA    1 
ATOM   1257 C  C     . ILE A 1 252 ? 52.440 -9.823  -18.349 1.00 49.78  ? 170 ILE A C     1 
ATOM   1258 O  O     . ILE A 1 252 ? 52.905 -9.714  -17.218 1.00 48.86  ? 170 ILE A O     1 
ATOM   1259 C  CB    . ILE A 1 252 ? 49.956 -10.029 -17.791 1.00 67.60  ? 170 ILE A CB    1 
ATOM   1260 C  CG1   . ILE A 1 252 ? 48.658 -10.298 -18.590 1.00 62.00  ? 170 ILE A CG1   1 
ATOM   1261 C  CG2   . ILE A 1 252 ? 50.127 -8.534  -17.468 1.00 65.41  ? 170 ILE A CG2   1 
ATOM   1262 C  CD1   . ILE A 1 252 ? 47.399 -10.060 -17.802 1.00 66.94  ? 170 ILE A CD1   1 
ATOM   1263 N  N     . VAL A 1 253 ? 52.985 -9.299  -19.457 1.00 45.97  ? 171 VAL A N     1 
ATOM   1264 C  CA    . VAL A 1 253 ? 54.177 -8.466  -19.445 1.00 49.54  ? 171 VAL A CA    1 
ATOM   1265 C  C     . VAL A 1 253 ? 54.007 -7.263  -20.383 1.00 48.70  ? 171 VAL A C     1 
ATOM   1266 O  O     . VAL A 1 253 ? 53.734 -7.442  -21.563 1.00 52.99  ? 171 VAL A O     1 
ATOM   1267 C  CB    . VAL A 1 253 ? 55.394 -9.328  -19.839 1.00 48.97  ? 171 VAL A CB    1 
ATOM   1268 C  CG1   . VAL A 1 253 ? 56.677 -8.509  -19.887 1.00 53.56  ? 171 VAL A CG1   1 
ATOM   1269 C  CG2   . VAL A 1 253 ? 55.590 -10.520 -18.908 1.00 46.97  ? 171 VAL A CG2   1 
ATOM   1270 N  N     . HIS A 1 254 ? 54.185 -6.040  -19.859 1.00 49.67  ? 172 HIS A N     1 
ATOM   1271 C  CA    . HIS A 1 254 ? 54.021 -4.810  -20.628 1.00 51.29  ? 172 HIS A CA    1 
ATOM   1272 C  C     . HIS A 1 254 ? 55.202 -3.856  -20.453 1.00 48.50  ? 172 HIS A C     1 
ATOM   1273 O  O     . HIS A 1 254 ? 55.444 -2.983  -21.282 1.00 46.71  ? 172 HIS A O     1 
ATOM   1274 C  CB    . HIS A 1 254 ? 52.758 -4.069  -20.182 1.00 54.38  ? 172 HIS A CB    1 
ATOM   1275 C  CG    . HIS A 1 254 ? 51.529 -4.791  -20.577 1.00 66.36  ? 172 HIS A CG    1 
ATOM   1276 N  ND1   . HIS A 1 254 ? 51.366 -5.263  -21.867 1.00 65.79  ? 172 HIS A ND1   1 
ATOM   1277 C  CD2   . HIS A 1 254 ? 50.415 -5.132  -19.887 1.00 65.00  ? 172 HIS A CD2   1 
ATOM   1278 C  CE1   . HIS A 1 254 ? 50.184 -5.882  -21.947 1.00 77.09  ? 172 HIS A CE1   1 
ATOM   1279 N  NE2   . HIS A 1 254 ? 49.588 -5.802  -20.763 1.00 67.95  ? 172 HIS A NE2   1 
ATOM   1280 N  N     . ASP A 1 255 ? 55.940 -4.043  -19.363 1.00 46.74  ? 173 ASP A N     1 
ATOM   1281 C  CA    . ASP A 1 255 ? 56.886 -3.067  -18.880 1.00 46.00  ? 173 ASP A CA    1 
ATOM   1282 C  C     . ASP A 1 255 ? 58.237 -3.287  -19.538 1.00 44.45  ? 173 ASP A C     1 
ATOM   1283 O  O     . ASP A 1 255 ? 59.247 -3.426  -18.847 1.00 42.23  ? 173 ASP A O     1 
ATOM   1284 C  CB    . ASP A 1 255 ? 56.953 -3.134  -17.366 1.00 45.51  ? 173 ASP A CB    1 
ATOM   1285 C  CG    . ASP A 1 255 ? 57.499 -1.884  -16.705 1.00 52.78  ? 173 ASP A CG    1 
ATOM   1286 O  OD1   . ASP A 1 255 ? 57.726 -0.870  -17.435 1.00 56.38  ? 173 ASP A OD1   1 
ATOM   1287 O  OD2   . ASP A 1 255 ? 57.732 -1.962  -15.483 1.00 58.47  ? 173 ASP A OD2   1 
ATOM   1288 N  N     . LEU A 1 256 ? 58.269 -3.197  -20.874 1.00 44.74  ? 174 LEU A N     1 
ATOM   1289 C  CA    . LEU A 1 256 ? 59.382 -3.780  -21.611 1.00 45.97  ? 174 LEU A CA    1 
ATOM   1290 C  C     . LEU A 1 256 ? 60.688 -3.065  -21.285 1.00 47.65  ? 174 LEU A C     1 
ATOM   1291 O  O     . LEU A 1 256 ? 61.732 -3.719  -21.244 1.00 52.52  ? 174 LEU A O     1 
ATOM   1292 C  CB    . LEU A 1 256 ? 59.219 -3.831  -23.125 1.00 43.55  ? 174 LEU A CB    1 
ATOM   1293 C  CG    . LEU A 1 256 ? 57.904 -4.376  -23.659 1.00 51.26  ? 174 LEU A CG    1 
ATOM   1294 C  CD1   . LEU A 1 256 ? 57.971 -4.297  -25.198 1.00 53.43  ? 174 LEU A CD1   1 
ATOM   1295 C  CD2   . LEU A 1 256 ? 57.653 -5.764  -23.112 1.00 50.53  ? 174 LEU A CD2   1 
ATOM   1296 N  N     . GLU A 1 257 ? 60.651 -1.731  -21.147 1.00 48.58  ? 175 GLU A N     1 
ATOM   1297 C  CA    . GLU A 1 257 ? 61.888 -0.963  -21.040 1.00 47.27  ? 175 GLU A CA    1 
ATOM   1298 C  C     . GLU A 1 257 ? 62.493 -1.178  -19.662 1.00 44.30  ? 175 GLU A C     1 
ATOM   1299 O  O     . GLU A 1 257 ? 63.682 -1.408  -19.557 1.00 42.10  ? 175 GLU A O     1 
ATOM   1300 C  CB    . GLU A 1 257 ? 61.724 0.517   -21.372 1.00 49.42  ? 175 GLU A CB    1 
ATOM   1301 C  CG    . GLU A 1 257 ? 62.884 1.407   -20.929 1.00 51.95  ? 175 GLU A CG    1 
ATOM   1302 C  CD    . GLU A 1 257 ? 62.972 2.695   -21.753 1.00 59.91  ? 175 GLU A CD    1 
ATOM   1303 O  OE1   . GLU A 1 257 ? 62.300 2.835   -22.830 1.00 55.34  ? 175 GLU A OE1   1 
ATOM   1304 O  OE2   . GLU A 1 257 ? 63.737 3.582   -21.308 1.00 50.74  ? 175 GLU A OE2   1 
ATOM   1305 N  N     . ARG A 1 258 ? 61.663 -1.178  -18.618 1.00 49.58  ? 176 ARG A N     1 
ATOM   1306 C  CA    . ARG A 1 258 ? 62.179 -1.473  -17.293 1.00 53.23  ? 176 ARG A CA    1 
ATOM   1307 C  C     . ARG A 1 258 ? 62.831 -2.855  -17.296 1.00 56.12  ? 176 ARG A C     1 
ATOM   1308 O  O     . ARG A 1 258 ? 63.938 -3.016  -16.777 1.00 56.98  ? 176 ARG A O     1 
ATOM   1309 C  CB    . ARG A 1 258 ? 61.124 -1.408  -16.189 1.00 57.31  ? 176 ARG A CB    1 
ATOM   1310 C  CG    . ARG A 1 258 ? 61.717 -1.938  -14.891 1.00 64.85  ? 176 ARG A CG    1 
ATOM   1311 C  CD    . ARG A 1 258 ? 60.876 -1.629  -13.687 1.00 67.43  ? 176 ARG A CD    1 
ATOM   1312 N  NE    . ARG A 1 258 ? 60.796 -0.173  -13.600 1.00 79.06  ? 176 ARG A NE    1 
ATOM   1313 C  CZ    . ARG A 1 258 ? 59.753 0.572   -13.921 1.00 77.44  ? 176 ARG A CZ    1 
ATOM   1314 N  NH1   . ARG A 1 258 ? 58.596 0.051   -14.294 1.00 66.87  ? 176 ARG A NH1   1 
ATOM   1315 N  NH2   . ARG A 1 258 ? 59.909 1.875   -13.895 1.00 93.20  ? 176 ARG A NH2   1 
ATOM   1316 N  N     . LEU A 1 259 ? 62.140 -3.846  -17.880 1.00 50.62  ? 177 LEU A N     1 
ATOM   1317 C  CA    . LEU A 1 259 ? 62.647 -5.206  -17.871 1.00 46.88  ? 177 LEU A CA    1 
ATOM   1318 C  C     . LEU A 1 259 ? 63.922 -5.342  -18.712 1.00 44.63  ? 177 LEU A C     1 
ATOM   1319 O  O     . LEU A 1 259 ? 64.842 -6.025  -18.300 1.00 57.71  ? 177 LEU A O     1 
ATOM   1320 C  CB    . LEU A 1 259 ? 61.515 -6.133  -18.298 1.00 46.14  ? 177 LEU A CB    1 
ATOM   1321 C  CG    . LEU A 1 259 ? 60.362 -6.268  -17.285 1.00 46.43  ? 177 LEU A CG    1 
ATOM   1322 C  CD1   . LEU A 1 259 ? 59.241 -7.032  -17.930 1.00 43.52  ? 177 LEU A CD1   1 
ATOM   1323 C  CD2   . LEU A 1 259 ? 60.693 -6.920  -15.949 1.00 43.19  ? 177 LEU A CD2   1 
ATOM   1324 N  N     . ARG A 1 260 ? 63.998 -4.694  -19.872 1.00 47.54  ? 178 ARG A N     1 
ATOM   1325 C  CA    . ARG A 1 260 ? 65.224 -4.617  -20.654 1.00 53.28  ? 178 ARG A CA    1 
ATOM   1326 C  C     . ARG A 1 260 ? 66.365 -4.099  -19.771 1.00 50.46  ? 178 ARG A C     1 
ATOM   1327 O  O     . ARG A 1 260 ? 67.507 -4.493  -19.919 1.00 55.48  ? 178 ARG A O     1 
ATOM   1328 C  CB    . ARG A 1 260 ? 65.101 -3.696  -21.881 1.00 57.58  ? 178 ARG A CB    1 
ATOM   1329 C  CG    . ARG A 1 260 ? 64.431 -4.303  -23.107 1.00 64.68  ? 178 ARG A CG    1 
ATOM   1330 C  CD    . ARG A 1 260 ? 64.360 -3.444  -24.390 1.00 73.26  ? 178 ARG A CD    1 
ATOM   1331 N  NE    . ARG A 1 260 ? 64.061 -2.014  -24.180 1.00 91.96  ? 178 ARG A NE    1 
ATOM   1332 C  CZ    . ARG A 1 260 ? 63.021 -1.292  -24.668 1.00 90.27  ? 178 ARG A CZ    1 
ATOM   1333 N  NH1   . ARG A 1 260 ? 61.971 -1.892  -25.220 1.00 89.97  ? 178 ARG A NH1   1 
ATOM   1334 N  NH2   . ARG A 1 260 ? 63.034 0.038   -24.591 1.00 72.70  ? 178 ARG A NH2   1 
ATOM   1335 N  N     . ARG A 1 261 ? 66.050 -3.222  -18.834 1.00 55.55  ? 179 ARG A N     1 
ATOM   1336 C  CA    . ARG A 1 261 ? 67.083 -2.471  -18.143 1.00 66.47  ? 179 ARG A CA    1 
ATOM   1337 C  C     . ARG A 1 261 ? 67.568 -3.196  -16.897 1.00 58.08  ? 179 ARG A C     1 
ATOM   1338 O  O     . ARG A 1 261 ? 68.737 -3.068  -16.545 1.00 57.02  ? 179 ARG A O     1 
ATOM   1339 C  CB    . ARG A 1 261 ? 66.627 -1.075  -17.706 1.00 68.03  ? 179 ARG A CB    1 
ATOM   1340 C  CG    . ARG A 1 261 ? 66.789 -0.093  -18.848 1.00 81.80  ? 179 ARG A CG    1 
ATOM   1341 C  CD    . ARG A 1 261 ? 66.838 1.320   -18.327 1.00 91.35  ? 179 ARG A CD    1 
ATOM   1342 N  NE    . ARG A 1 261 ? 66.473 2.128   -19.492 1.00 86.99  ? 179 ARG A NE    1 
ATOM   1343 C  CZ    . ARG A 1 261 ? 66.960 3.292   -19.850 1.00 73.68  ? 179 ARG A CZ    1 
ATOM   1344 N  NH1   . ARG A 1 261 ? 67.976 3.839   -19.194 1.00 67.98  ? 179 ARG A NH1   1 
ATOM   1345 N  NH2   . ARG A 1 261 ? 66.389 3.897   -20.878 1.00 76.11  ? 179 ARG A NH2   1 
ATOM   1346 N  N     . ASP A 1 262 ? 66.649 -3.872  -16.206 1.00 52.42  ? 180 ASP A N     1 
ATOM   1347 C  CA    . ASP A 1 262 ? 66.992 -4.601  -15.000 1.00 54.46  ? 180 ASP A CA    1 
ATOM   1348 C  C     . ASP A 1 262 ? 67.578 -5.966  -15.332 1.00 52.21  ? 180 ASP A C     1 
ATOM   1349 O  O     . ASP A 1 262 ? 68.063 -6.615  -14.419 1.00 51.27  ? 180 ASP A O     1 
ATOM   1350 C  CB    . ASP A 1 262 ? 65.784 -4.827  -14.111 1.00 59.54  ? 180 ASP A CB    1 
ATOM   1351 C  CG    . ASP A 1 262 ? 65.313 -3.586  -13.382 1.00 56.95  ? 180 ASP A CG    1 
ATOM   1352 O  OD1   . ASP A 1 262 ? 66.051 -2.607  -13.479 1.00 59.13  ? 180 ASP A OD1   1 
ATOM   1353 O  OD2   . ASP A 1 262 ? 64.235 -3.630  -12.735 1.00 62.31  ? 180 ASP A OD2   1 
ATOM   1354 N  N     . TYR A 1 263 ? 67.512 -6.410  -16.602 1.00 51.25  ? 181 TYR A N     1 
ATOM   1355 C  CA    . TYR A 1 263 ? 67.811 -7.801  -16.903 1.00 51.43  ? 181 TYR A CA    1 
ATOM   1356 C  C     . TYR A 1 263 ? 69.317 -8.025  -16.722 1.00 56.89  ? 181 TYR A C     1 
ATOM   1357 O  O     . TYR A 1 263 ? 69.723 -9.015  -16.109 1.00 58.81  ? 181 TYR A O     1 
ATOM   1358 C  CB    . TYR A 1 263 ? 67.313 -8.286  -18.271 1.00 51.48  ? 181 TYR A CB    1 
ATOM   1359 C  CG    . TYR A 1 263 ? 66.862 -9.737  -18.186 1.00 52.95  ? 181 TYR A CG    1 
ATOM   1360 C  CD1   . TYR A 1 263 ? 67.752 -10.797 -18.325 1.00 52.05  ? 181 TYR A CD1   1 
ATOM   1361 C  CD2   . TYR A 1 263 ? 65.550 -10.051 -17.869 1.00 58.73  ? 181 TYR A CD2   1 
ATOM   1362 C  CE1   . TYR A 1 263 ? 67.339 -12.116 -18.176 1.00 52.34  ? 181 TYR A CE1   1 
ATOM   1363 C  CE2   . TYR A 1 263 ? 65.120 -11.361 -17.718 1.00 56.48  ? 181 TYR A CE2   1 
ATOM   1364 C  CZ    . TYR A 1 263 ? 66.015 -12.401 -17.874 1.00 53.47  ? 181 TYR A CZ    1 
ATOM   1365 O  OH    . TYR A 1 263 ? 65.543 -13.668 -17.739 1.00 45.89  ? 181 TYR A OH    1 
ATOM   1366 N  N     . GLY A 1 264 ? 70.134 -7.089  -17.229 1.00 52.46  ? 182 GLY A N     1 
ATOM   1367 C  CA    . GLY A 1 264 ? 71.583 -7.190  -17.169 1.00 44.76  ? 182 GLY A CA    1 
ATOM   1368 C  C     . GLY A 1 264 ? 72.094 -7.619  -15.794 1.00 45.92  ? 182 GLY A C     1 
ATOM   1369 O  O     . GLY A 1 264 ? 72.802 -8.619  -15.703 1.00 51.25  ? 182 GLY A O     1 
ATOM   1370 N  N     . ASP A 1 265 ? 71.709 -6.871  -14.747 1.00 43.63  ? 183 ASP A N     1 
ATOM   1371 C  CA    . ASP A 1 265 ? 72.101 -7.121  -13.370 1.00 45.59  ? 183 ASP A CA    1 
ATOM   1372 C  C     . ASP A 1 265 ? 71.600 -8.497  -12.935 1.00 48.99  ? 183 ASP A C     1 
ATOM   1373 O  O     . ASP A 1 265 ? 72.309 -9.239  -12.268 1.00 56.75  ? 183 ASP A O     1 
ATOM   1374 C  CB    . ASP A 1 265 ? 71.570 -6.031  -12.443 1.00 51.49  ? 183 ASP A CB    1 
ATOM   1375 C  CG    . ASP A 1 265 ? 71.607 -6.291  -10.929 1.00 65.82  ? 183 ASP A CG    1 
ATOM   1376 O  OD1   . ASP A 1 265 ? 72.690 -6.173  -10.347 1.00 66.25  ? 183 ASP A OD1   1 
ATOM   1377 O  OD2   . ASP A 1 265 ? 70.533 -6.572  -10.308 1.00 77.10  ? 183 ASP A OD2   1 
ATOM   1378 N  N     . PHE A 1 266 ? 70.345 -8.804  -13.276 1.00 48.32  ? 184 PHE A N     1 
ATOM   1379 C  CA    . PHE A 1 266 ? 69.723 -10.056 -12.900 1.00 42.37  ? 184 PHE A CA    1 
ATOM   1380 C  C     . PHE A 1 266 ? 70.519 -11.196 -13.537 1.00 44.43  ? 184 PHE A C     1 
ATOM   1381 O  O     . PHE A 1 266 ? 71.000 -12.086 -12.839 1.00 43.90  ? 184 PHE A O     1 
ATOM   1382 C  CB    . PHE A 1 266 ? 68.243 -10.018 -13.304 1.00 38.81  ? 184 PHE A CB    1 
ATOM   1383 C  CG    . PHE A 1 266 ? 67.576 -11.388 -13.330 1.00 39.38  ? 184 PHE A CG    1 
ATOM   1384 C  CD1   . PHE A 1 266 ? 67.345 -12.087 -12.154 1.00 41.12  ? 184 PHE A CD1   1 
ATOM   1385 C  CD2   . PHE A 1 266 ? 67.215 -11.989 -14.525 1.00 45.20  ? 184 PHE A CD2   1 
ATOM   1386 C  CE1   . PHE A 1 266 ? 66.750 -13.329 -12.168 1.00 43.90  ? 184 PHE A CE1   1 
ATOM   1387 C  CE2   . PHE A 1 266 ? 66.650 -13.254 -14.537 1.00 46.21  ? 184 PHE A CE2   1 
ATOM   1388 C  CZ    . PHE A 1 266 ? 66.419 -13.920 -13.361 1.00 48.02  ? 184 PHE A CZ    1 
ATOM   1389 N  N     . TYR A 1 267 ? 70.658 -11.167 -14.864 1.00 40.19  ? 185 TYR A N     1 
ATOM   1390 C  CA    . TYR A 1 267 ? 71.336 -12.239 -15.573 1.00 47.06  ? 185 TYR A CA    1 
ATOM   1391 C  C     . TYR A 1 267 ? 72.771 -12.430 -15.068 1.00 46.77  ? 185 TYR A C     1 
ATOM   1392 O  O     . TYR A 1 267 ? 73.214 -13.553 -14.909 1.00 46.06  ? 185 TYR A O     1 
ATOM   1393 C  CB    . TYR A 1 267 ? 71.350 -11.932 -17.069 1.00 51.71  ? 185 TYR A CB    1 
ATOM   1394 C  CG    . TYR A 1 267 ? 71.964 -13.021 -17.930 1.00 55.41  ? 185 TYR A CG    1 
ATOM   1395 C  CD1   . TYR A 1 267 ? 71.280 -14.209 -18.159 1.00 59.05  ? 185 TYR A CD1   1 
ATOM   1396 C  CD2   . TYR A 1 267 ? 73.207 -12.854 -18.531 1.00 60.84  ? 185 TYR A CD2   1 
ATOM   1397 C  CE1   . TYR A 1 267 ? 71.806 -15.200 -18.970 1.00 64.51  ? 185 TYR A CE1   1 
ATOM   1398 C  CE2   . TYR A 1 267 ? 73.749 -13.841 -19.340 1.00 63.87  ? 185 TYR A CE2   1 
ATOM   1399 C  CZ    . TYR A 1 267 ? 73.051 -15.022 -19.553 1.00 71.74  ? 185 TYR A CZ    1 
ATOM   1400 O  OH    . TYR A 1 267 ? 73.554 -16.020 -20.345 1.00 74.30  ? 185 TYR A OH    1 
ATOM   1401 N  N     . HIS A 1 268 ? 73.501 -11.348 -14.791 1.00 51.70  ? 186 HIS A N     1 
ATOM   1402 C  CA    . HIS A 1 268 ? 74.887 -11.482 -14.370 1.00 53.20  ? 186 HIS A CA    1 
ATOM   1403 C  C     . HIS A 1 268 ? 74.968 -12.020 -12.948 1.00 51.93  ? 186 HIS A C     1 
ATOM   1404 O  O     . HIS A 1 268 ? 75.887 -12.777 -12.669 1.00 56.01  ? 186 HIS A O     1 
ATOM   1405 C  CB    . HIS A 1 268 ? 75.720 -10.237 -14.702 1.00 57.87  ? 186 HIS A CB    1 
ATOM   1406 C  CG    . HIS A 1 268 ? 75.970 -10.154 -16.195 1.00 82.02  ? 186 HIS A CG    1 
ATOM   1407 N  ND1   . HIS A 1 268 ? 75.142 -9.476  -17.083 1.00 92.15  ? 186 HIS A ND1   1 
ATOM   1408 C  CD2   . HIS A 1 268 ? 76.924 -10.734 -16.961 1.00 78.16  ? 186 HIS A CD2   1 
ATOM   1409 C  CE1   . HIS A 1 268 ? 75.597 -9.614  -18.325 1.00 84.63  ? 186 HIS A CE1   1 
ATOM   1410 N  NE2   . HIS A 1 268 ? 76.672 -10.385 -18.278 1.00 79.16  ? 186 HIS A NE2   1 
ATOM   1411 N  N     . THR A 1 269 ? 74.027 -11.660 -12.060 1.00 51.01  ? 187 THR A N     1 
ATOM   1412 C  CA    . THR A 1 269 ? 73.988 -12.239 -10.717 1.00 49.27  ? 187 THR A CA    1 
ATOM   1413 C  C     . THR A 1 269 ? 73.708 -13.749 -10.804 1.00 57.05  ? 187 THR A C     1 
ATOM   1414 O  O     . THR A 1 269 ? 74.258 -14.543 -10.040 1.00 56.08  ? 187 THR A O     1 
ATOM   1415 C  CB    . THR A 1 269 ? 72.932 -11.510 -9.888  1.00 48.46  ? 187 THR A CB    1 
ATOM   1416 O  OG1   . THR A 1 269 ? 73.290 -10.126 -9.884  1.00 50.77  ? 187 THR A OG1   1 
ATOM   1417 C  CG2   . THR A 1 269 ? 72.801 -12.043 -8.468  1.00 53.64  ? 187 THR A CG2   1 
ATOM   1418 N  N     . VAL A 1 270 ? 72.856 -14.147 -11.760 1.00 51.83  ? 188 VAL A N     1 
ATOM   1419 C  CA    . VAL A 1 270 ? 72.486 -15.537 -11.937 1.00 55.83  ? 188 VAL A CA    1 
ATOM   1420 C  C     . VAL A 1 270 ? 73.731 -16.333 -12.340 1.00 52.79  ? 188 VAL A C     1 
ATOM   1421 O  O     . VAL A 1 270 ? 74.014 -17.356 -11.731 1.00 48.86  ? 188 VAL A O     1 
ATOM   1422 C  CB    . VAL A 1 270 ? 71.317 -15.692 -12.939 1.00 52.52  ? 188 VAL A CB    1 
ATOM   1423 C  CG1   . VAL A 1 270 ? 71.090 -17.128 -13.374 1.00 51.51  ? 188 VAL A CG1   1 
ATOM   1424 C  CG2   . VAL A 1 270 ? 70.017 -15.160 -12.370 1.00 51.12  ? 188 VAL A CG2   1 
ATOM   1425 N  N     . ARG A 1 271 ? 74.468 -15.849 -13.348 1.00 52.51  ? 189 ARG A N     1 
ATOM   1426 C  CA    . ARG A 1 271 ? 75.612 -16.552 -13.915 1.00 56.54  ? 189 ARG A CA    1 
ATOM   1427 C  C     . ARG A 1 271 ? 76.769 -16.625 -12.910 1.00 56.44  ? 189 ARG A C     1 
ATOM   1428 O  O     . ARG A 1 271 ? 77.328 -17.696 -12.686 1.00 56.10  ? 189 ARG A O     1 
ATOM   1429 C  CB    . ARG A 1 271 ? 76.029 -15.866 -15.221 1.00 55.69  ? 189 ARG A CB    1 
ATOM   1430 C  CG    . ARG A 1 271 ? 75.103 -16.151 -16.392 1.00 56.39  ? 189 ARG A CG    1 
ATOM   1431 C  CD    . ARG A 1 271 ? 75.121 -17.607 -16.797 1.00 60.38  ? 189 ARG A CD    1 
ATOM   1432 N  NE    . ARG A 1 271 ? 74.117 -17.801 -17.852 1.00 78.36  ? 189 ARG A NE    1 
ATOM   1433 C  CZ    . ARG A 1 271 ? 72.965 -18.518 -17.818 1.00 76.49  ? 189 ARG A CZ    1 
ATOM   1434 N  NH1   . ARG A 1 271 ? 72.542 -19.157 -16.730 1.00 62.62  ? 189 ARG A NH1   1 
ATOM   1435 N  NH2   . ARG A 1 271 ? 72.223 -18.579 -18.915 1.00 72.24  ? 189 ARG A NH2   1 
ATOM   1436 N  N     . GLN A 1 272 ? 77.073 -15.504 -12.256 1.00 51.87  ? 190 GLN A N     1 
ATOM   1437 C  CA    . GLN A 1 272 ? 78.101 -15.483 -11.243 1.00 58.26  ? 190 GLN A CA    1 
ATOM   1438 C  C     . GLN A 1 272 ? 77.763 -16.526 -10.179 1.00 53.08  ? 190 GLN A C     1 
ATOM   1439 O  O     . GLN A 1 272 ? 78.680 -17.106 -9.634  1.00 58.39  ? 190 GLN A O     1 
ATOM   1440 C  CB    . GLN A 1 272 ? 78.416 -14.084 -10.700 1.00 64.91  ? 190 GLN A CB    1 
ATOM   1441 C  CG    . GLN A 1 272 ? 77.733 -13.722 -9.383  1.00 79.65  ? 190 GLN A CG    1 
ATOM   1442 C  CD    . GLN A 1 272 ? 78.167 -12.380 -8.800  1.00 92.79  ? 190 GLN A CD    1 
ATOM   1443 O  OE1   . GLN A 1 272 ? 77.357 -11.484 -8.482  1.00 71.53  ? 190 GLN A OE1   1 
ATOM   1444 N  NE2   . GLN A 1 272 ? 79.475 -12.239 -8.627  1.00 75.97  ? 190 GLN A NE2   1 
ATOM   1445 N  N     . HIS A 1 273 ? 76.483 -16.797 -9.902  1.00 52.28  ? 191 HIS A N     1 
ATOM   1446 C  CA    . HIS A 1 273 ? 76.105 -17.805 -8.912  1.00 47.87  ? 191 HIS A CA    1 
ATOM   1447 C  C     . HIS A 1 273 ? 75.922 -19.205 -9.518  1.00 48.68  ? 191 HIS A C     1 
ATOM   1448 O  O     . HIS A 1 273 ? 75.672 -20.156 -8.782  1.00 45.90  ? 191 HIS A O     1 
ATOM   1449 C  CB    . HIS A 1 273 ? 74.831 -17.389 -8.183  1.00 48.03  ? 191 HIS A CB    1 
ATOM   1450 C  CG    . HIS A 1 273 ? 75.111 -16.319 -7.197  1.00 48.48  ? 191 HIS A CG    1 
ATOM   1451 N  ND1   . HIS A 1 273 ? 75.167 -16.571 -5.840  1.00 55.40  ? 191 HIS A ND1   1 
ATOM   1452 C  CD2   . HIS A 1 273 ? 75.316 -15.011 -7.354  1.00 39.38  ? 191 HIS A CD2   1 
ATOM   1453 C  CE1   . HIS A 1 273 ? 75.427 -15.434 -5.196  1.00 52.02  ? 191 HIS A CE1   1 
ATOM   1454 N  NE2   . HIS A 1 273 ? 75.520 -14.475 -6.103  1.00 49.76  ? 191 HIS A NE2   1 
ATOM   1455 N  N     . GLY A 1 274 ? 76.052 -19.334 -10.849 1.00 44.82  ? 192 GLY A N     1 
ATOM   1456 C  CA    . GLY A 1 274 ? 76.048 -20.626 -11.503 1.00 47.93  ? 192 GLY A CA    1 
ATOM   1457 C  C     . GLY A 1 274 ? 74.649 -21.237 -11.627 1.00 50.68  ? 192 GLY A C     1 
ATOM   1458 O  O     . GLY A 1 274 ? 74.522 -22.437 -11.863 1.00 49.16  ? 192 GLY A O     1 
ATOM   1459 N  N     . ALA A 1 275 ? 73.602 -20.398 -11.558 1.00 48.79  ? 193 ALA A N     1 
ATOM   1460 C  CA    . ALA A 1 275 ? 72.225 -20.865 -11.595 1.00 44.94  ? 193 ALA A CA    1 
ATOM   1461 C  C     . ALA A 1 275 ? 71.690 -20.834 -13.034 1.00 44.93  ? 193 ALA A C     1 
ATOM   1462 O  O     . ALA A 1 275 ? 72.270 -20.193 -13.900 1.00 40.63  ? 193 ALA A O     1 
ATOM   1463 C  CB    . ALA A 1 275 ? 71.402 -20.043 -10.653 1.00 43.16  ? 193 ALA A CB    1 
ATOM   1464 N  N     . ARG A 1 276 ? 70.592 -21.555 -13.253 1.00 45.03  ? 194 ARG A N     1 
ATOM   1465 C  CA    . ARG A 1 276 ? 69.966 -21.608 -14.594 1.00 49.98  ? 194 ARG A CA    1 
ATOM   1466 C  C     . ARG A 1 276 ? 68.596 -20.917 -14.556 1.00 50.52  ? 194 ARG A C     1 
ATOM   1467 O  O     . ARG A 1 276 ? 68.028 -20.789 -13.463 1.00 51.18  ? 194 ARG A O     1 
ATOM   1468 C  CB    . ARG A 1 276 ? 69.881 -23.065 -15.055 1.00 52.24  ? 194 ARG A CB    1 
ATOM   1469 C  CG    . ARG A 1 276 ? 71.192 -23.833 -15.041 1.00 61.10  ? 194 ARG A CG    1 
ATOM   1470 C  CD    . ARG A 1 276 ? 71.757 -23.961 -16.441 1.00 67.31  ? 194 ARG A CD    1 
ATOM   1471 N  NE    . ARG A 1 276 ? 72.381 -22.718 -16.902 1.00 69.98  ? 194 ARG A NE    1 
ATOM   1472 C  CZ    . ARG A 1 276 ? 73.643 -22.384 -16.694 1.00 77.14  ? 194 ARG A CZ    1 
ATOM   1473 N  NH1   . ARG A 1 276 ? 74.077 -22.158 -15.467 1.00 78.46  ? 194 ARG A NH1   1 
ATOM   1474 N  NH2   . ARG A 1 276 ? 74.467 -22.271 -17.718 1.00 80.44  ? 194 ARG A NH2   1 
ATOM   1475 N  N     . ILE A 1 277 ? 68.095 -20.496 -15.712 1.00 47.53  ? 195 ILE A N     1 
ATOM   1476 C  CA    . ILE A 1 277 ? 66.842 -19.774 -15.813 1.00 48.13  ? 195 ILE A CA    1 
ATOM   1477 C  C     . ILE A 1 277 ? 65.913 -20.557 -16.737 1.00 45.13  ? 195 ILE A C     1 
ATOM   1478 O  O     . ILE A 1 277 ? 66.254 -20.834 -17.880 1.00 48.45  ? 195 ILE A O     1 
ATOM   1479 C  CB    . ILE A 1 277 ? 67.051 -18.332 -16.321 1.00 46.84  ? 195 ILE A CB    1 
ATOM   1480 C  CG1   . ILE A 1 277 ? 67.979 -17.515 -15.411 1.00 44.09  ? 195 ILE A CG1   1 
ATOM   1481 C  CG2   . ILE A 1 277 ? 65.705 -17.627 -16.524 1.00 45.56  ? 195 ILE A CG2   1 
ATOM   1482 C  CD1   . ILE A 1 277 ? 68.428 -16.189 -16.010 1.00 41.21  ? 195 ILE A CD1   1 
ATOM   1483 N  N     . VAL A 1 278 ? 64.710 -20.838 -16.235 1.00 40.33  ? 196 VAL A N     1 
ATOM   1484 C  CA    . VAL A 1 278 ? 63.658 -21.438 -17.016 1.00 40.12  ? 196 VAL A CA    1 
ATOM   1485 C  C     . VAL A 1 278 ? 62.442 -20.510 -16.980 1.00 46.16  ? 196 VAL A C     1 
ATOM   1486 O  O     . VAL A 1 278 ? 62.025 -20.071 -15.898 1.00 42.51  ? 196 VAL A O     1 
ATOM   1487 C  CB    . VAL A 1 278 ? 63.319 -22.827 -16.457 1.00 40.45  ? 196 VAL A CB    1 
ATOM   1488 C  CG1   . VAL A 1 278 ? 62.178 -23.450 -17.256 1.00 40.66  ? 196 VAL A CG1   1 
ATOM   1489 C  CG2   . VAL A 1 278 ? 64.552 -23.737 -16.406 1.00 44.08  ? 196 VAL A CG2   1 
ATOM   1490 N  N     . ILE A 1 279 ? 61.891 -20.241 -18.175 1.00 40.98  ? 197 ILE A N     1 
ATOM   1491 C  CA    . ILE A 1 279 ? 60.705 -19.434 -18.307 1.00 46.61  ? 197 ILE A CA    1 
ATOM   1492 C  C     . ILE A 1 279 ? 59.607 -20.327 -18.850 1.00 47.46  ? 197 ILE A C     1 
ATOM   1493 O  O     . ILE A 1 279 ? 59.902 -21.255 -19.588 1.00 44.11  ? 197 ILE A O     1 
ATOM   1494 C  CB    . ILE A 1 279 ? 60.929 -18.225 -19.234 1.00 52.31  ? 197 ILE A CB    1 
ATOM   1495 C  CG1   . ILE A 1 279 ? 61.557 -18.628 -20.557 1.00 50.53  ? 197 ILE A CG1   1 
ATOM   1496 C  CG2   . ILE A 1 279 ? 61.748 -17.136 -18.548 1.00 53.10  ? 197 ILE A CG2   1 
ATOM   1497 C  CD1   . ILE A 1 279 ? 61.353 -17.600 -21.662 1.00 50.80  ? 197 ILE A CD1   1 
ATOM   1498 N  N     . GLY A 1 280 ? 58.362 -20.003 -18.468 1.00 48.20  ? 198 GLY A N     1 
ATOM   1499 C  CA    . GLY A 1 280 ? 57.162 -20.452 -19.156 1.00 45.59  ? 198 GLY A CA    1 
ATOM   1500 C  C     . GLY A 1 280 ? 56.004 -19.470 -18.953 1.00 45.33  ? 198 GLY A C     1 
ATOM   1501 O  O     . GLY A 1 280 ? 56.060 -18.572 -18.104 1.00 45.71  ? 198 GLY A O     1 
ATOM   1502 N  N     . GLY A 1 281 ? 54.942 -19.692 -19.727 1.00 43.88  ? 199 GLY A N     1 
ATOM   1503 C  CA    . GLY A 1 281 ? 53.714 -18.912 -19.653 1.00 45.18  ? 199 GLY A CA    1 
ATOM   1504 C  C     . GLY A 1 281 ? 53.421 -18.191 -20.968 1.00 42.55  ? 199 GLY A C     1 
ATOM   1505 O  O     . GLY A 1 281 ? 54.316 -18.017 -21.797 1.00 44.62  ? 199 GLY A O     1 
ATOM   1506 N  N     . ALA A 1 282 ? 52.182 -17.698 -21.108 1.00 44.99  ? 200 ALA A N     1 
ATOM   1507 C  CA    . ALA A 1 282 ? 51.692 -17.148 -22.377 1.00 47.28  ? 200 ALA A CA    1 
ATOM   1508 C  C     . ALA A 1 282 ? 52.445 -15.883 -22.790 1.00 51.62  ? 200 ALA A C     1 
ATOM   1509 O  O     . ALA A 1 282 ? 52.516 -15.610 -23.999 1.00 49.10  ? 200 ALA A O     1 
ATOM   1510 C  CB    . ALA A 1 282 ? 50.195 -16.897 -22.347 1.00 38.88  ? 200 ALA A CB    1 
ATOM   1511 N  N     . ALA A 1 283 ? 52.990 -15.123 -21.809 1.00 44.02  ? 201 ALA A N     1 
ATOM   1512 C  CA    . ALA A 1 283 ? 53.638 -13.857 -22.142 1.00 42.43  ? 201 ALA A CA    1 
ATOM   1513 C  C     . ALA A 1 283 ? 54.749 -14.084 -23.163 1.00 42.15  ? 201 ALA A C     1 
ATOM   1514 O  O     . ALA A 1 283 ? 55.077 -13.196 -23.935 1.00 46.47  ? 201 ALA A O     1 
ATOM   1515 C  CB    . ALA A 1 283 ? 54.174 -13.158 -20.912 1.00 41.21  ? 201 ALA A CB    1 
ATOM   1516 N  N     . PHE A 1 284 ? 55.329 -15.287 -23.166 1.00 45.03  ? 202 PHE A N     1 
ATOM   1517 C  CA    . PHE A 1 284 ? 56.511 -15.524 -23.966 1.00 45.14  ? 202 PHE A CA    1 
ATOM   1518 C  C     . PHE A 1 284 ? 56.140 -15.964 -25.379 1.00 47.28  ? 202 PHE A C     1 
ATOM   1519 O  O     . PHE A 1 284 ? 56.997 -16.371 -26.142 1.00 47.88  ? 202 PHE A O     1 
ATOM   1520 C  CB    . PHE A 1 284 ? 57.325 -16.564 -23.218 1.00 42.23  ? 202 PHE A CB    1 
ATOM   1521 C  CG    . PHE A 1 284 ? 57.856 -16.043 -21.895 1.00 40.43  ? 202 PHE A CG    1 
ATOM   1522 C  CD1   . PHE A 1 284 ? 58.703 -14.952 -21.856 1.00 41.86  ? 202 PHE A CD1   1 
ATOM   1523 C  CD2   . PHE A 1 284 ? 57.586 -16.707 -20.708 1.00 42.40  ? 202 PHE A CD2   1 
ATOM   1524 C  CE1   . PHE A 1 284 ? 59.217 -14.498 -20.652 1.00 43.90  ? 202 PHE A CE1   1 
ATOM   1525 C  CE2   . PHE A 1 284 ? 58.116 -16.262 -19.509 1.00 44.53  ? 202 PHE A CE2   1 
ATOM   1526 C  CZ    . PHE A 1 284 ? 58.921 -15.149 -19.483 1.00 44.70  ? 202 PHE A CZ    1 
ATOM   1527 N  N     . ALA A 1 285 ? 54.861 -15.905 -25.722 1.00 51.84  ? 203 ALA A N     1 
ATOM   1528 C  CA    . ALA A 1 285 ? 54.466 -16.028 -27.114 1.00 57.78  ? 203 ALA A CA    1 
ATOM   1529 C  C     . ALA A 1 285 ? 54.922 -14.779 -27.870 1.00 56.07  ? 203 ALA A C     1 
ATOM   1530 O  O     . ALA A 1 285 ? 55.236 -14.873 -29.049 1.00 61.62  ? 203 ALA A O     1 
ATOM   1531 C  CB    . ALA A 1 285 ? 52.969 -16.253 -27.227 1.00 49.41  ? 203 ALA A CB    1 
ATOM   1532 N  N     . ASP A 1 286 ? 54.973 -13.630 -27.176 1.00 52.20  ? 204 ASP A N     1 
ATOM   1533 C  CA    . ASP A 1 286 ? 55.485 -12.402 -27.751 1.00 56.92  ? 204 ASP A CA    1 
ATOM   1534 C  C     . ASP A 1 286 ? 57.011 -12.488 -27.853 1.00 58.05  ? 204 ASP A C     1 
ATOM   1535 O  O     . ASP A 1 286 ? 57.701 -12.634 -26.843 1.00 54.16  ? 204 ASP A O     1 
ATOM   1536 C  CB    . ASP A 1 286 ? 55.007 -11.185 -26.970 1.00 61.85  ? 204 ASP A CB    1 
ATOM   1537 C  CG    . ASP A 1 286 ? 55.462 -9.822  -27.497 1.00 62.16  ? 204 ASP A CG    1 
ATOM   1538 O  OD1   . ASP A 1 286 ? 56.680 -9.517  -27.487 1.00 67.02  ? 204 ASP A OD1   1 
ATOM   1539 O  OD2   . ASP A 1 286 ? 54.600 -9.047  -27.891 1.00 64.73  ? 204 ASP A OD2   1 
ATOM   1540 N  N     . PRO A 1 287 ? 57.601 -12.307 -29.057 1.00 61.56  ? 205 PRO A N     1 
ATOM   1541 C  CA    . PRO A 1 287 ? 59.039 -12.507 -29.249 1.00 56.67  ? 205 PRO A CA    1 
ATOM   1542 C  C     . PRO A 1 287 ? 59.878 -11.416 -28.596 1.00 52.27  ? 205 PRO A C     1 
ATOM   1543 O  O     . PRO A 1 287 ? 61.067 -11.609 -28.313 1.00 47.81  ? 205 PRO A O     1 
ATOM   1544 C  CB    . PRO A 1 287 ? 59.203 -12.502 -30.787 1.00 61.90  ? 205 PRO A CB    1 
ATOM   1545 C  CG    . PRO A 1 287 ? 57.798 -12.526 -31.343 1.00 65.79  ? 205 PRO A CG    1 
ATOM   1546 C  CD    . PRO A 1 287 ? 56.936 -11.848 -30.288 1.00 63.77  ? 205 PRO A CD    1 
ATOM   1547 N  N     . GLN A 1 288 ? 59.264 -10.247 -28.392 1.00 48.53  ? 206 GLN A N     1 
ATOM   1548 C  CA    . GLN A 1 288 ? 59.967 -9.155  -27.740 1.00 50.40  ? 206 GLN A CA    1 
ATOM   1549 C  C     . GLN A 1 288 ? 60.136 -9.529  -26.283 1.00 46.52  ? 206 GLN A C     1 
ATOM   1550 O  O     . GLN A 1 288 ? 61.199 -9.315  -25.722 1.00 45.29  ? 206 GLN A O     1 
ATOM   1551 C  CB    . GLN A 1 288 ? 59.304 -7.775  -27.783 1.00 53.17  ? 206 GLN A CB    1 
ATOM   1552 C  CG    . GLN A 1 288 ? 59.111 -7.235  -29.194 1.00 56.95  ? 206 GLN A CG    1 
ATOM   1553 C  CD    . GLN A 1 288 ? 60.461 -6.993  -29.814 1.00 66.44  ? 206 GLN A CD    1 
ATOM   1554 O  OE1   . GLN A 1 288 ? 61.461 -6.834  -29.094 1.00 59.27  ? 206 GLN A OE1   1 
ATOM   1555 N  NE2   . GLN A 1 288 ? 60.503 -6.995  -31.137 1.00 70.66  ? 206 GLN A NE2   1 
ATOM   1556 N  N     . VAL A 1 289 ? 59.098 -10.116 -25.695 1.00 44.01  ? 207 VAL A N     1 
ATOM   1557 C  CA    . VAL A 1 289 ? 59.175 -10.472 -24.286 1.00 49.99  ? 207 VAL A CA    1 
ATOM   1558 C  C     . VAL A 1 289 ? 60.205 -11.594 -24.104 1.00 49.98  ? 207 VAL A C     1 
ATOM   1559 O  O     . VAL A 1 289 ? 60.991 -11.546 -23.158 1.00 55.26  ? 207 VAL A O     1 
ATOM   1560 C  CB    . VAL A 1 289 ? 57.799 -10.878 -23.722 1.00 54.65  ? 207 VAL A CB    1 
ATOM   1561 C  CG1   . VAL A 1 289 ? 57.889 -11.253 -22.246 1.00 52.97  ? 207 VAL A CG1   1 
ATOM   1562 C  CG2   . VAL A 1 289 ? 56.730 -9.804  -23.955 1.00 54.72  ? 207 VAL A CG2   1 
ATOM   1563 N  N     . ARG A 1 290 ? 60.184 -12.592 -25.009 1.00 46.68  ? 208 ARG A N     1 
ATOM   1564 C  CA    . ARG A 1 290 ? 61.092 -13.737 -24.987 1.00 46.89  ? 208 ARG A CA    1 
ATOM   1565 C  C     . ARG A 1 290 ? 62.547 -13.284 -25.179 1.00 44.16  ? 208 ARG A C     1 
ATOM   1566 O  O     . ARG A 1 290 ? 63.455 -13.766 -24.515 1.00 57.42  ? 208 ARG A O     1 
ATOM   1567 C  CB    . ARG A 1 290 ? 60.532 -14.769 -25.980 1.00 49.40  ? 208 ARG A CB    1 
ATOM   1568 C  CG    . ARG A 1 290 ? 61.438 -15.941 -26.323 1.00 56.35  ? 208 ARG A CG    1 
ATOM   1569 C  CD    . ARG A 1 290 ? 60.744 -17.027 -27.131 1.00 57.75  ? 208 ARG A CD    1 
ATOM   1570 N  NE    . ARG A 1 290 ? 60.619 -16.754 -28.569 1.00 63.47  ? 208 ARG A NE    1 
ATOM   1571 C  CZ    . ARG A 1 290 ? 59.479 -16.664 -29.272 1.00 70.91  ? 208 ARG A CZ    1 
ATOM   1572 N  NH1   . ARG A 1 290 ? 58.287 -16.723 -28.712 1.00 72.35  ? 208 ARG A NH1   1 
ATOM   1573 N  NH2   . ARG A 1 290 ? 59.519 -16.482 -30.572 1.00 83.49  ? 208 ARG A NH2   1 
ATOM   1574 N  N     . GLU A 1 291 ? 62.770 -12.304 -26.049 1.00 50.76  ? 209 GLU A N     1 
ATOM   1575 C  CA    . GLU A 1 291 ? 64.089 -11.714 -26.276 1.00 54.20  ? 209 GLU A CA    1 
ATOM   1576 C  C     . GLU A 1 291 ? 64.682 -11.132 -24.993 1.00 46.88  ? 209 GLU A C     1 
ATOM   1577 O  O     . GLU A 1 291 ? 65.837 -11.346 -24.659 1.00 56.32  ? 209 GLU A O     1 
ATOM   1578 C  CB    . GLU A 1 291 ? 63.923 -10.611 -27.329 1.00 57.62  ? 209 GLU A CB    1 
ATOM   1579 C  CG    . GLU A 1 291 ? 65.235 -10.117 -27.918 1.00 64.03  ? 209 GLU A CG    1 
ATOM   1580 C  CD    . GLU A 1 291 ? 65.945 -11.196 -28.723 1.00 76.71  ? 209 GLU A CD    1 
ATOM   1581 O  OE1   . GLU A 1 291 ? 65.322 -12.211 -29.136 1.00 80.28  ? 209 GLU A OE1   1 
ATOM   1582 O  OE2   . GLU A 1 291 ? 67.169 -11.022 -28.911 1.00 90.37  ? 209 GLU A OE2   1 
ATOM   1583 N  N     . ILE A 1 292 ? 63.874 -10.367 -24.275 1.00 51.01  ? 210 ILE A N     1 
ATOM   1584 C  CA    . ILE A 1 292 ? 64.299 -9.718  -23.045 1.00 50.66  ? 210 ILE A CA    1 
ATOM   1585 C  C     . ILE A 1 292 ? 64.708 -10.777 -22.025 1.00 47.65  ? 210 ILE A C     1 
ATOM   1586 O  O     . ILE A 1 292 ? 65.672 -10.565 -21.311 1.00 42.97  ? 210 ILE A O     1 
ATOM   1587 C  CB    . ILE A 1 292 ? 63.174 -8.790  -22.520 1.00 46.94  ? 210 ILE A CB    1 
ATOM   1588 C  CG1   . ILE A 1 292 ? 62.943 -7.606  -23.484 1.00 51.20  ? 210 ILE A CG1   1 
ATOM   1589 C  CG2   . ILE A 1 292 ? 63.434 -8.290  -21.095 1.00 48.21  ? 210 ILE A CG2   1 
ATOM   1590 C  CD1   . ILE A 1 292 ? 61.661 -6.821  -23.233 1.00 49.95  ? 210 ILE A CD1   1 
ATOM   1591 N  N     . PHE A 1 293 ? 63.908 -11.847 -21.897 1.00 48.06  ? 211 PHE A N     1 
ATOM   1592 C  CA    . PHE A 1 293 ? 64.047 -12.777 -20.781 1.00 57.85  ? 211 PHE A CA    1 
ATOM   1593 C  C     . PHE A 1 293 ? 65.022 -13.889 -21.168 1.00 57.44  ? 211 PHE A C     1 
ATOM   1594 O  O     . PHE A 1 293 ? 64.620 -15.029 -21.414 1.00 49.18  ? 211 PHE A O     1 
ATOM   1595 C  CB    . PHE A 1 293 ? 62.701 -13.342 -20.314 1.00 54.87  ? 211 PHE A CB    1 
ATOM   1596 C  CG    . PHE A 1 293 ? 61.878 -12.430 -19.411 1.00 53.55  ? 211 PHE A CG    1 
ATOM   1597 C  CD1   . PHE A 1 293 ? 61.159 -11.355 -19.931 1.00 53.92  ? 211 PHE A CD1   1 
ATOM   1598 C  CD2   . PHE A 1 293 ? 61.798 -12.662 -18.045 1.00 51.43  ? 211 PHE A CD2   1 
ATOM   1599 C  CE1   . PHE A 1 293 ? 60.386 -10.547 -19.108 1.00 53.09  ? 211 PHE A CE1   1 
ATOM   1600 C  CE2   . PHE A 1 293 ? 61.028 -11.841 -17.227 1.00 54.78  ? 211 PHE A CE2   1 
ATOM   1601 C  CZ    . PHE A 1 293 ? 60.323 -10.789 -17.755 1.00 51.88  ? 211 PHE A CZ    1 
ATOM   1602 N  N     . ILE A 1 294 ? 66.298 -13.503 -21.233 1.00 52.16  ? 212 ILE A N     1 
ATOM   1603 C  CA    . ILE A 1 294 ? 67.381 -14.402 -21.563 1.00 53.85  ? 212 ILE A CA    1 
ATOM   1604 C  C     . ILE A 1 294 ? 67.307 -15.573 -20.605 1.00 48.66  ? 212 ILE A C     1 
ATOM   1605 O  O     . ILE A 1 294 ? 67.238 -15.361 -19.394 1.00 48.82  ? 212 ILE A O     1 
ATOM   1606 C  CB    . ILE A 1 294 ? 68.749 -13.698 -21.475 1.00 59.45  ? 212 ILE A CB    1 
ATOM   1607 C  CG1   . ILE A 1 294 ? 68.887 -12.581 -22.533 1.00 57.60  ? 212 ILE A CG1   1 
ATOM   1608 C  CG2   . ILE A 1 294 ? 69.900 -14.720 -21.555 1.00 53.34  ? 212 ILE A CG2   1 
ATOM   1609 C  CD1   . ILE A 1 294 ? 70.083 -11.667 -22.296 1.00 58.39  ? 212 ILE A CD1   1 
ATOM   1610 N  N     . HIS A 1 295 ? 67.362 -16.785 -21.178 1.00 48.83  ? 213 HIS A N     1 
ATOM   1611 C  CA    . HIS A 1 295 ? 66.942 -17.993 -20.493 1.00 47.34  ? 213 HIS A CA    1 
ATOM   1612 C  C     . HIS A 1 295 ? 67.740 -19.199 -20.988 1.00 50.76  ? 213 HIS A C     1 
ATOM   1613 O  O     . HIS A 1 295 ? 68.211 -19.247 -22.141 1.00 46.42  ? 213 HIS A O     1 
ATOM   1614 C  CB    . HIS A 1 295 ? 65.434 -18.206 -20.693 1.00 45.08  ? 213 HIS A CB    1 
ATOM   1615 C  CG    . HIS A 1 295 ? 65.010 -18.373 -22.117 1.00 47.45  ? 213 HIS A CG    1 
ATOM   1616 N  ND1   . HIS A 1 295 ? 64.656 -17.319 -22.929 1.00 49.84  ? 213 HIS A ND1   1 
ATOM   1617 C  CD2   . HIS A 1 295 ? 64.881 -19.472 -22.883 1.00 51.44  ? 213 HIS A CD2   1 
ATOM   1618 C  CE1   . HIS A 1 295 ? 64.328 -17.777 -24.138 1.00 52.32  ? 213 HIS A CE1   1 
ATOM   1619 N  NE2   . HIS A 1 295 ? 64.456 -19.086 -24.137 1.00 49.97  ? 213 HIS A NE2   1 
ATOM   1620 N  N     . ASP A 1 296 ? 67.811 -20.199 -20.100 1.00 47.66  ? 214 ASP A N     1 
ATOM   1621 C  CA    . ASP A 1 296 ? 68.425 -21.479 -20.411 1.00 46.31  ? 214 ASP A CA    1 
ATOM   1622 C  C     . ASP A 1 296 ? 67.423 -22.447 -21.007 1.00 45.05  ? 214 ASP A C     1 
ATOM   1623 O  O     . ASP A 1 296 ? 67.825 -23.306 -21.779 1.00 49.85  ? 214 ASP A O     1 
ATOM   1624 C  CB    . ASP A 1 296 ? 69.098 -22.059 -19.189 1.00 45.13  ? 214 ASP A CB    1 
ATOM   1625 C  CG    . ASP A 1 296 ? 70.207 -21.149 -18.699 1.00 45.58  ? 214 ASP A CG    1 
ATOM   1626 O  OD1   . ASP A 1 296 ? 71.213 -21.008 -19.399 1.00 47.62  ? 214 ASP A OD1   1 
ATOM   1627 O  OD2   . ASP A 1 296 ? 70.014 -20.521 -17.683 1.00 57.59  ? 214 ASP A OD2   1 
ATOM   1628 N  N     . TYR A 1 297 ? 66.137 -22.285 -20.671 1.00 44.81  ? 215 TYR A N     1 
ATOM   1629 C  CA    . TYR A 1 297 ? 65.109 -23.181 -21.179 1.00 45.63  ? 215 TYR A CA    1 
ATOM   1630 C  C     . TYR A 1 297 ? 63.755 -22.480 -21.121 1.00 43.06  ? 215 TYR A C     1 
ATOM   1631 O  O     . TYR A 1 297 ? 63.336 -21.989 -20.095 1.00 49.09  ? 215 TYR A O     1 
ATOM   1632 C  CB    . TYR A 1 297 ? 65.005 -24.559 -20.489 1.00 44.36  ? 215 TYR A CB    1 
ATOM   1633 C  CG    . TYR A 1 297 ? 64.064 -25.504 -21.235 1.00 43.71  ? 215 TYR A CG    1 
ATOM   1634 C  CD1   . TYR A 1 297 ? 64.355 -25.937 -22.531 1.00 45.75  ? 215 TYR A CD1   1 
ATOM   1635 C  CD2   . TYR A 1 297 ? 62.873 -25.940 -20.676 1.00 41.47  ? 215 TYR A CD2   1 
ATOM   1636 C  CE1   . TYR A 1 297 ? 63.505 -26.782 -23.230 1.00 42.48  ? 215 TYR A CE1   1 
ATOM   1637 C  CE2   . TYR A 1 297 ? 61.999 -26.763 -21.382 1.00 42.51  ? 215 TYR A CE2   1 
ATOM   1638 C  CZ    . TYR A 1 297 ? 62.307 -27.170 -22.667 1.00 41.20  ? 215 TYR A CZ    1 
ATOM   1639 O  OH    . TYR A 1 297 ? 61.454 -27.981 -23.354 1.00 43.61  ? 215 TYR A OH    1 
ATOM   1640 N  N     . GLN A 1 298 ? 63.050 -22.499 -22.245 1.00 44.84  ? 216 GLN A N     1 
ATOM   1641 C  CA    . GLN A 1 298 ? 61.681 -22.059 -22.308 1.00 41.38  ? 216 GLN A CA    1 
ATOM   1642 C  C     . GLN A 1 298 ? 60.801 -23.283 -22.462 1.00 44.39  ? 216 GLN A C     1 
ATOM   1643 O  O     . GLN A 1 298 ? 60.929 -23.987 -23.452 1.00 49.89  ? 216 GLN A O     1 
ATOM   1644 C  CB    . GLN A 1 298 ? 61.425 -21.168 -23.516 1.00 44.54  ? 216 GLN A CB    1 
ATOM   1645 C  CG    . GLN A 1 298 ? 59.947 -20.869 -23.719 1.00 45.26  ? 216 GLN A CG    1 
ATOM   1646 C  CD    . GLN A 1 298 ? 59.716 -20.093 -24.986 1.00 43.58  ? 216 GLN A CD    1 
ATOM   1647 O  OE1   . GLN A 1 298 ? 60.645 -19.924 -25.774 1.00 55.81  ? 216 GLN A OE1   1 
ATOM   1648 N  NE2   . GLN A 1 298 ? 58.494 -19.620 -25.183 1.00 42.20  ? 216 GLN A NE2   1 
ATOM   1649 N  N     . ALA A 1 299 ? 59.894 -23.463 -21.495 1.00 49.59  ? 217 ALA A N     1 
ATOM   1650 C  CA    . ALA A 1 299 ? 59.011 -24.603 -21.382 1.00 45.09  ? 217 ALA A CA    1 
ATOM   1651 C  C     . ALA A 1 299 ? 57.647 -24.308 -21.991 1.00 41.97  ? 217 ALA A C     1 
ATOM   1652 O  O     . ALA A 1 299 ? 57.102 -23.248 -21.763 1.00 51.44  ? 217 ALA A O     1 
ATOM   1653 C  CB    . ALA A 1 299 ? 58.880 -24.920 -19.915 1.00 46.27  ? 217 ALA A CB    1 
ATOM   1654 N  N     . ALA A 1 300 ? 57.079 -25.275 -22.719 1.00 48.10  ? 218 ALA A N     1 
ATOM   1655 C  CA    . ALA A 1 300 ? 55.687 -25.251 -23.163 1.00 41.34  ? 218 ALA A CA    1 
ATOM   1656 C  C     . ALA A 1 300 ? 54.734 -25.642 -22.030 1.00 43.02  ? 218 ALA A C     1 
ATOM   1657 O  O     . ALA A 1 300 ? 53.627 -25.107 -21.920 1.00 49.35  ? 218 ALA A O     1 
ATOM   1658 C  CB    . ALA A 1 300 ? 55.515 -26.210 -24.322 1.00 36.17  ? 218 ALA A CB    1 
ATOM   1659 N  N     . GLY A 1 301 ? 55.146 -26.628 -21.231 1.00 44.33  ? 219 GLY A N     1 
ATOM   1660 C  CA    . GLY A 1 301 ? 54.356 -27.108 -20.110 1.00 43.14  ? 219 GLY A CA    1 
ATOM   1661 C  C     . GLY A 1 301 ? 55.243 -27.844 -19.110 1.00 44.79  ? 219 GLY A C     1 
ATOM   1662 O  O     . GLY A 1 301 ? 56.460 -27.681 -19.097 1.00 47.87  ? 219 GLY A O     1 
ATOM   1663 N  N     . LEU A 1 302 ? 54.610 -28.668 -18.281 1.00 45.96  ? 220 LEU A N     1 
ATOM   1664 C  CA    . LEU A 1 302 ? 55.284 -29.326 -17.188 1.00 41.89  ? 220 LEU A CA    1 
ATOM   1665 C  C     . LEU A 1 302 ? 56.023 -30.553 -17.684 1.00 48.43  ? 220 LEU A C     1 
ATOM   1666 O  O     . LEU A 1 302 ? 57.047 -30.897 -17.101 1.00 52.18  ? 220 LEU A O     1 
ATOM   1667 C  CB    . LEU A 1 302 ? 54.244 -29.710 -16.158 1.00 41.28  ? 220 LEU A CB    1 
ATOM   1668 C  CG    . LEU A 1 302 ? 53.418 -28.555 -15.598 1.00 40.92  ? 220 LEU A CG    1 
ATOM   1669 C  CD1   . LEU A 1 302 ? 52.354 -29.088 -14.669 1.00 46.14  ? 220 LEU A CD1   1 
ATOM   1670 C  CD2   . LEU A 1 302 ? 54.341 -27.648 -14.869 1.00 44.30  ? 220 LEU A CD2   1 
ATOM   1671 N  N     . THR A 1 303 ? 55.500 -31.198 -18.737 1.00 50.59  ? 221 THR A N     1 
ATOM   1672 C  CA    . THR A 1 303 ? 56.086 -32.443 -19.232 1.00 48.60  ? 221 THR A CA    1 
ATOM   1673 C  C     . THR A 1 303 ? 57.483 -32.181 -19.782 1.00 42.08  ? 221 THR A C     1 
ATOM   1674 O  O     . THR A 1 303 ? 58.393 -32.926 -19.450 1.00 47.98  ? 221 THR A O     1 
ATOM   1675 C  CB    . THR A 1 303 ? 55.209 -33.126 -20.288 1.00 47.02  ? 221 THR A CB    1 
ATOM   1676 O  OG1   . THR A 1 303 ? 54.156 -33.704 -19.520 1.00 48.49  ? 221 THR A OG1   1 
ATOM   1677 C  CG2   . THR A 1 303 ? 55.937 -34.204 -21.077 1.00 40.67  ? 221 THR A CG2   1 
ATOM   1678 N  N     . ASP A 1 304 ? 57.655 -31.129 -20.589 1.00 39.60  ? 222 ASP A N     1 
ATOM   1679 C  CA    . ASP A 1 304 ? 58.946 -30.878 -21.232 1.00 42.74  ? 222 ASP A CA    1 
ATOM   1680 C  C     . ASP A 1 304 ? 59.892 -30.189 -20.261 1.00 41.47  ? 222 ASP A C     1 
ATOM   1681 O  O     . ASP A 1 304 ? 61.116 -30.271 -20.425 1.00 43.74  ? 222 ASP A O     1 
ATOM   1682 C  CB    . ASP A 1 304 ? 58.854 -30.104 -22.546 1.00 38.48  ? 222 ASP A CB    1 
ATOM   1683 C  CG    . ASP A 1 304 ? 58.354 -28.675 -22.427 1.00 43.97  ? 222 ASP A CG    1 
ATOM   1684 O  OD1   . ASP A 1 304 ? 57.181 -28.490 -22.036 1.00 46.25  ? 222 ASP A OD1   1 
ATOM   1685 O  OD2   . ASP A 1 304 ? 59.151 -27.758 -22.707 1.00 46.24  ? 222 ASP A OD2   1 
ATOM   1686 N  N     . PHE A 1 305 ? 59.311 -29.482 -19.277 1.00 47.04  ? 223 PHE A N     1 
ATOM   1687 C  CA    . PHE A 1 305 ? 60.085 -28.902 -18.178 1.00 45.65  ? 223 PHE A CA    1 
ATOM   1688 C  C     . PHE A 1 305 ? 60.793 -30.024 -17.420 1.00 44.15  ? 223 PHE A C     1 
ATOM   1689 O  O     . PHE A 1 305 ? 61.988 -29.946 -17.178 1.00 44.42  ? 223 PHE A O     1 
ATOM   1690 C  CB    . PHE A 1 305 ? 59.153 -28.094 -17.275 1.00 42.34  ? 223 PHE A CB    1 
ATOM   1691 C  CG    . PHE A 1 305 ? 59.716 -27.599 -15.943 1.00 41.46  ? 223 PHE A CG    1 
ATOM   1692 C  CD1   . PHE A 1 305 ? 60.860 -26.805 -15.893 1.00 43.66  ? 223 PHE A CD1   1 
ATOM   1693 C  CD2   . PHE A 1 305 ? 59.050 -27.860 -14.751 1.00 37.73  ? 223 PHE A CD2   1 
ATOM   1694 C  CE1   . PHE A 1 305 ? 61.339 -26.316 -14.685 1.00 45.67  ? 223 PHE A CE1   1 
ATOM   1695 C  CE2   . PHE A 1 305 ? 59.513 -27.349 -13.547 1.00 40.36  ? 223 PHE A CE2   1 
ATOM   1696 C  CZ    . PHE A 1 305 ? 60.663 -26.594 -13.510 1.00 43.79  ? 223 PHE A CZ    1 
ATOM   1697 N  N     . LEU A 1 306 ? 60.040 -31.077 -17.084 1.00 43.09  ? 224 LEU A N     1 
ATOM   1698 C  CA    . LEU A 1 306 ? 60.597 -32.262 -16.460 1.00 44.72  ? 224 LEU A CA    1 
ATOM   1699 C  C     . LEU A 1 306 ? 61.690 -32.871 -17.327 1.00 45.58  ? 224 LEU A C     1 
ATOM   1700 O  O     . LEU A 1 306 ? 62.689 -33.308 -16.778 1.00 39.88  ? 224 LEU A O     1 
ATOM   1701 C  CB    . LEU A 1 306 ? 59.504 -33.289 -16.205 1.00 48.59  ? 224 LEU A CB    1 
ATOM   1702 C  CG    . LEU A 1 306 ? 58.899 -33.276 -14.806 1.00 56.18  ? 224 LEU A CG    1 
ATOM   1703 C  CD1   . LEU A 1 306 ? 57.652 -34.124 -14.771 1.00 58.86  ? 224 LEU A CD1   1 
ATOM   1704 C  CD2   . LEU A 1 306 ? 59.930 -33.793 -13.829 1.00 57.62  ? 224 LEU A CD2   1 
ATOM   1705 N  N     . ASP A 1 307 ? 61.487 -32.954 -18.654 1.00 45.65  ? 225 ASP A N     1 
ATOM   1706 C  CA    . ASP A 1 307 ? 62.521 -33.521 -19.503 1.00 50.23  ? 225 ASP A CA    1 
ATOM   1707 C  C     . ASP A 1 307 ? 63.771 -32.689 -19.300 1.00 44.69  ? 225 ASP A C     1 
ATOM   1708 O  O     . ASP A 1 307 ? 64.835 -33.247 -19.110 1.00 57.27  ? 225 ASP A O     1 
ATOM   1709 C  CB    . ASP A 1 307 ? 62.110 -33.690 -20.961 1.00 58.86  ? 225 ASP A CB    1 
ATOM   1710 C  CG    . ASP A 1 307 ? 61.331 -34.970 -21.226 1.00 81.12  ? 225 ASP A CG    1 
ATOM   1711 O  OD1   . ASP A 1 307 ? 61.975 -36.040 -21.106 1.00 85.29  ? 225 ASP A OD1   1 
ATOM   1712 O  OD2   . ASP A 1 307 ? 60.085 -34.893 -21.505 1.00 83.42  ? 225 ASP A OD2   1 
ATOM   1713 N  N     . TYR A 1 308 ? 63.613 -31.365 -19.290 1.00 45.31  ? 226 TYR A N     1 
ATOM   1714 C  CA    . TYR A 1 308 ? 64.729 -30.457 -19.098 1.00 46.93  ? 226 TYR A CA    1 
ATOM   1715 C  C     . TYR A 1 308 ? 65.397 -30.737 -17.749 1.00 43.99  ? 226 TYR A C     1 
ATOM   1716 O  O     . TYR A 1 308 ? 66.625 -30.792 -17.669 1.00 44.74  ? 226 TYR A O     1 
ATOM   1717 C  CB    . TYR A 1 308 ? 64.352 -28.969 -19.215 1.00 42.71  ? 226 TYR A CB    1 
ATOM   1718 C  CG    . TYR A 1 308 ? 65.507 -28.014 -18.903 1.00 38.88  ? 226 TYR A CG    1 
ATOM   1719 C  CD1   . TYR A 1 308 ? 66.530 -27.825 -19.819 1.00 40.91  ? 226 TYR A CD1   1 
ATOM   1720 C  CD2   . TYR A 1 308 ? 65.618 -27.343 -17.680 1.00 37.90  ? 226 TYR A CD2   1 
ATOM   1721 C  CE1   . TYR A 1 308 ? 67.590 -26.965 -19.567 1.00 38.32  ? 226 TYR A CE1   1 
ATOM   1722 C  CE2   . TYR A 1 308 ? 66.704 -26.526 -17.390 1.00 39.54  ? 226 TYR A CE2   1 
ATOM   1723 C  CZ    . TYR A 1 308 ? 67.696 -26.333 -18.342 1.00 41.54  ? 226 TYR A CZ    1 
ATOM   1724 O  OH    . TYR A 1 308 ? 68.794 -25.536 -18.155 1.00 44.82  ? 226 TYR A OH    1 
ATOM   1725 N  N     . LEU A 1 309 ? 64.604 -30.858 -16.686 1.00 43.50  ? 227 LEU A N     1 
ATOM   1726 C  CA    . LEU A 1 309 ? 65.174 -31.052 -15.357 1.00 51.33  ? 227 LEU A CA    1 
ATOM   1727 C  C     . LEU A 1 309 ? 66.038 -32.316 -15.332 1.00 44.85  ? 227 LEU A C     1 
ATOM   1728 O  O     . LEU A 1 309 ? 67.139 -32.310 -14.772 1.00 41.86  ? 227 LEU A O     1 
ATOM   1729 C  CB    . LEU A 1 309 ? 64.085 -31.094 -14.285 1.00 45.97  ? 227 LEU A CB    1 
ATOM   1730 C  CG    . LEU A 1 309 ? 63.335 -29.775 -14.067 1.00 40.69  ? 227 LEU A CG    1 
ATOM   1731 C  CD1   . LEU A 1 309 ? 62.217 -29.929 -13.077 1.00 41.10  ? 227 LEU A CD1   1 
ATOM   1732 C  CD2   . LEU A 1 309 ? 64.272 -28.741 -13.568 1.00 46.17  ? 227 LEU A CD2   1 
ATOM   1733 N  N     . ARG A 1 310 ? 65.572 -33.371 -16.002 1.00 48.64  ? 228 ARG A N     1 
ATOM   1734 C  CA    . ARG A 1 310 ? 66.200 -34.686 -15.898 1.00 53.66  ? 228 ARG A CA    1 
ATOM   1735 C  C     . ARG A 1 310 ? 67.547 -34.688 -16.618 1.00 50.51  ? 228 ARG A C     1 
ATOM   1736 O  O     . ARG A 1 310 ? 68.451 -35.393 -16.191 1.00 53.98  ? 228 ARG A O     1 
ATOM   1737 C  CB    . ARG A 1 310 ? 65.295 -35.828 -16.369 1.00 50.75  ? 228 ARG A CB    1 
ATOM   1738 C  CG    . ARG A 1 310 ? 64.057 -36.066 -15.509 1.00 57.32  ? 228 ARG A CG    1 
ATOM   1739 C  CD    . ARG A 1 310 ? 63.154 -37.095 -16.230 1.00 76.28  ? 228 ARG A CD    1 
ATOM   1740 N  NE    . ARG A 1 310 ? 61.817 -37.293 -15.648 1.00 87.85  ? 228 ARG A NE    1 
ATOM   1741 C  CZ    . ARG A 1 310 ? 61.596 -37.533 -14.356 1.00 92.09  ? 228 ARG A CZ    1 
ATOM   1742 N  NH1   . ARG A 1 310 ? 62.611 -37.606 -13.513 1.00 83.96  ? 228 ARG A NH1   1 
ATOM   1743 N  NH2   . ARG A 1 310 ? 60.366 -37.681 -13.899 1.00 94.14  ? 228 ARG A NH2   1 
ATOM   1744 N  N     . ARG A 1 311 ? 67.672 -33.876 -17.678 1.00 54.50  ? 229 ARG A N     1 
ATOM   1745 C  CA    . ARG A 1 311 ? 68.891 -33.811 -18.472 1.00 50.28  ? 229 ARG A CA    1 
ATOM   1746 C  C     . ARG A 1 311 ? 69.826 -32.806 -17.785 1.00 49.76  ? 229 ARG A C     1 
ATOM   1747 O  O     . ARG A 1 311 ? 71.033 -33.021 -17.720 1.00 47.52  ? 229 ARG A O     1 
ATOM   1748 C  CB    . ARG A 1 311 ? 68.565 -33.577 -19.964 1.00 44.81  ? 229 ARG A CB    1 
ATOM   1749 C  CG    . ARG A 1 311 ? 68.641 -32.123 -20.411 1.00 62.77  ? 229 ARG A CG    1 
ATOM   1750 C  CD    . ARG A 1 311 ? 68.376 -31.812 -21.892 1.00 61.16  ? 229 ARG A CD    1 
ATOM   1751 N  NE    . ARG A 1 311 ? 67.012 -32.200 -22.259 1.00 64.86  ? 229 ARG A NE    1 
ATOM   1752 C  CZ    . ARG A 1 311 ? 66.044 -31.365 -22.618 1.00 64.96  ? 229 ARG A CZ    1 
ATOM   1753 N  NH1   . ARG A 1 311 ? 66.287 -30.068 -22.787 1.00 77.09  ? 229 ARG A NH1   1 
ATOM   1754 N  NH2   . ARG A 1 311 ? 64.842 -31.847 -22.823 1.00 54.80  ? 229 ARG A NH2   1 
ATOM   1755 N  N     . GLU A 1 312 ? 69.270 -31.705 -17.255 1.00 44.25  ? 230 GLU A N     1 
ATOM   1756 C  CA    . GLU A 1 312 ? 70.104 -30.627 -16.771 1.00 43.11  ? 230 GLU A CA    1 
ATOM   1757 C  C     . GLU A 1 312 ? 70.472 -30.846 -15.300 1.00 48.41  ? 230 GLU A C     1 
ATOM   1758 O  O     . GLU A 1 312 ? 71.585 -30.491 -14.898 1.00 43.52  ? 230 GLU A O     1 
ATOM   1759 C  CB    . GLU A 1 312 ? 69.463 -29.264 -16.986 1.00 44.94  ? 230 GLU A CB    1 
ATOM   1760 C  CG    . GLU A 1 312 ? 70.361 -28.120 -16.522 1.00 43.59  ? 230 GLU A CG    1 
ATOM   1761 C  CD    . GLU A 1 312 ? 71.593 -27.831 -17.354 1.00 45.36  ? 230 GLU A CD    1 
ATOM   1762 O  OE1   . GLU A 1 312 ? 71.666 -28.273 -18.513 1.00 57.56  ? 230 GLU A OE1   1 
ATOM   1763 O  OE2   . GLU A 1 312 ? 72.492 -27.126 -16.846 1.00 49.01  ? 230 GLU A OE2   1 
ATOM   1764 N  N     . PHE A 1 313 ? 69.548 -31.405 -14.506 1.00 41.46  ? 231 PHE A N     1 
ATOM   1765 C  CA    . PHE A 1 313 ? 69.801 -31.660 -13.100 1.00 41.92  ? 231 PHE A CA    1 
ATOM   1766 C  C     . PHE A 1 313 ? 69.501 -33.114 -12.748 1.00 51.89  ? 231 PHE A C     1 
ATOM   1767 O  O     . PHE A 1 313 ? 68.551 -33.391 -12.020 1.00 48.45  ? 231 PHE A O     1 
ATOM   1768 C  CB    . PHE A 1 313 ? 68.880 -30.743 -12.307 1.00 42.98  ? 231 PHE A CB    1 
ATOM   1769 C  CG    . PHE A 1 313 ? 69.199 -29.272 -12.509 1.00 48.11  ? 231 PHE A CG    1 
ATOM   1770 C  CD1   . PHE A 1 313 ? 70.343 -28.709 -11.951 1.00 45.25  ? 231 PHE A CD1   1 
ATOM   1771 C  CD2   . PHE A 1 313 ? 68.345 -28.453 -13.233 1.00 55.87  ? 231 PHE A CD2   1 
ATOM   1772 C  CE1   . PHE A 1 313 ? 70.642 -27.380 -12.138 1.00 44.43  ? 231 PHE A CE1   1 
ATOM   1773 C  CE2   . PHE A 1 313 ? 68.623 -27.106 -13.371 1.00 56.81  ? 231 PHE A CE2   1 
ATOM   1774 C  CZ    . PHE A 1 313 ? 69.776 -26.577 -12.834 1.00 52.30  ? 231 PHE A CZ    1 
ATOM   1775 N  N     . PRO A 1 314 ? 70.319 -34.079 -13.226 1.00 53.33  ? 232 PRO A N     1 
ATOM   1776 C  CA    . PRO A 1 314 ? 70.031 -35.507 -13.039 1.00 53.62  ? 232 PRO A CA    1 
ATOM   1777 C  C     . PRO A 1 314 ? 70.354 -35.928 -11.607 1.00 55.95  ? 232 PRO A C     1 
ATOM   1778 O  O     . PRO A 1 314 ? 71.255 -35.358 -10.993 1.00 62.60  ? 232 PRO A O     1 
ATOM   1779 C  CB    . PRO A 1 314 ? 70.967 -36.163 -14.068 1.00 50.68  ? 232 PRO A CB    1 
ATOM   1780 C  CG    . PRO A 1 314 ? 72.167 -35.236 -14.102 1.00 51.37  ? 232 PRO A CG    1 
ATOM   1781 C  CD    . PRO A 1 314 ? 71.603 -33.832 -13.902 1.00 48.92  ? 232 PRO A CD    1 
ATOM   1782 N  N     . THR A 1 315 ? 69.606 -36.900 -11.076 1.00 59.57  ? 233 THR A N     1 
ATOM   1783 C  CA    . THR A 1 315 ? 69.856 -37.412 -9.730  1.00 71.32  ? 233 THR A CA    1 
ATOM   1784 C  C     . THR A 1 315 ? 70.279 -38.870 -9.854  1.00 70.78  ? 233 THR A C     1 
ATOM   1785 O  O     . THR A 1 315 ? 69.835 -39.553 -10.775 1.00 66.60  ? 233 THR A O     1 
ATOM   1786 C  CB    . THR A 1 315 ? 68.640 -37.267 -8.806  1.00 67.99  ? 233 THR A CB    1 
ATOM   1787 O  OG1   . THR A 1 315 ? 67.496 -37.548 -9.607  1.00 67.06  ? 233 THR A OG1   1 
ATOM   1788 C  CG2   . THR A 1 315 ? 68.490 -35.868 -8.231  1.00 67.49  ? 233 THR A CG2   1 
ATOM   1789 N  N     . PRO A 1 316 ? 71.104 -39.377 -8.909  1.00 76.53  ? 234 PRO A N     1 
ATOM   1790 C  CA    . PRO A 1 316 ? 71.808 -40.651 -9.072  1.00 80.37  ? 234 PRO A CA    1 
ATOM   1791 C  C     . PRO A 1 316 ? 70.935 -41.845 -9.430  1.00 83.39  ? 234 PRO A C     1 
ATOM   1792 O  O     . PRO A 1 316 ? 71.290 -42.609 -10.322 1.00 99.24  ? 234 PRO A O     1 
ATOM   1793 C  CB    . PRO A 1 316 ? 72.466 -40.852 -7.713  1.00 77.67  ? 234 PRO A CB    1 
ATOM   1794 C  CG    . PRO A 1 316 ? 72.637 -39.454 -7.185  1.00 87.44  ? 234 PRO A CG    1 
ATOM   1795 C  CD    . PRO A 1 316 ? 71.375 -38.747 -7.609  1.00 84.87  ? 234 PRO A CD    1 
ATOM   1796 N  N     . ALA A 1 317 ? 69.820 -42.013 -8.714  1.00 82.84  ? 235 ALA A N     1 
ATOM   1797 C  CA    . ALA A 1 317 ? 68.963 -43.172 -8.914  1.00 112.34 ? 235 ALA A CA    1 
ATOM   1798 C  C     . ALA A 1 317 ? 67.643 -42.968 -8.168  1.00 115.80 ? 235 ALA A C     1 
ATOM   1799 O  O     . ALA A 1 317 ? 66.663 -42.730 -8.896  1.00 111.85 ? 235 ALA A O     1 
ATOM   1800 C  CB    . ALA A 1 317 ? 69.650 -44.455 -8.460  1.00 112.27 ? 235 ALA A CB    1 
ATOM   1801 N  N     . LEU B 1 95  ? 63.717 -21.200 23.454  1.00 74.03  ? 13  LEU B N     1 
ATOM   1802 C  CA    . LEU B 1 95  ? 62.431 -21.037 22.712  1.00 87.63  ? 13  LEU B CA    1 
ATOM   1803 C  C     . LEU B 1 95  ? 61.246 -21.415 23.599  1.00 99.26  ? 13  LEU B C     1 
ATOM   1804 O  O     . LEU B 1 95  ? 60.282 -20.649 23.706  1.00 88.79  ? 13  LEU B O     1 
ATOM   1805 C  CB    . LEU B 1 95  ? 62.344 -21.828 21.401  1.00 83.78  ? 13  LEU B CB    1 
ATOM   1806 C  CG    . LEU B 1 95  ? 60.938 -21.937 20.772  1.00 82.56  ? 13  LEU B CG    1 
ATOM   1807 C  CD1   . LEU B 1 95  ? 60.276 -20.602 20.434  1.00 73.57  ? 13  LEU B CD1   1 
ATOM   1808 C  CD2   . LEU B 1 95  ? 60.928 -22.797 19.511  1.00 77.51  ? 13  LEU B CD2   1 
ATOM   1809 N  N     . ASP B 1 96  ? 61.292 -22.637 24.153  1.00 107.16 ? 14  ASP B N     1 
ATOM   1810 C  CA    . ASP B 1 96  ? 60.239 -23.138 25.029  1.00 106.61 ? 14  ASP B CA    1 
ATOM   1811 C  C     . ASP B 1 96  ? 60.094 -22.210 26.240  1.00 110.17 ? 14  ASP B C     1 
ATOM   1812 O  O     . ASP B 1 96  ? 59.003 -22.087 26.799  1.00 101.62 ? 14  ASP B O     1 
ATOM   1813 C  CB    . ASP B 1 96  ? 60.459 -24.606 25.375  1.00 105.56 ? 14  ASP B CB    1 
ATOM   1814 C  CG    . ASP B 1 96  ? 60.453 -25.575 24.197  1.00 100.98 ? 14  ASP B CG    1 
ATOM   1815 O  OD1   . ASP B 1 96  ? 61.431 -25.557 23.402  1.00 83.90  ? 14  ASP B OD1   1 
ATOM   1816 O  OD2   . ASP B 1 96  ? 59.457 -26.322 24.069  1.00 92.43  ? 14  ASP B OD2   1 
ATOM   1817 N  N     . GLN B 1 97  ? 61.203 -21.548 26.617  1.00 113.94 ? 15  GLN B N     1 
ATOM   1818 C  CA    . GLN B 1 97  ? 61.215 -20.446 27.573  1.00 111.60 ? 15  GLN B CA    1 
ATOM   1819 C  C     . GLN B 1 97  ? 60.271 -19.328 27.119  1.00 105.83 ? 15  GLN B C     1 
ATOM   1820 O  O     . GLN B 1 97  ? 59.409 -18.888 27.891  1.00 88.85  ? 15  GLN B O     1 
ATOM   1821 C  CB    . GLN B 1 97  ? 62.664 -19.969 27.738  1.00 117.46 ? 15  GLN B CB    1 
ATOM   1822 C  CG    . GLN B 1 97  ? 62.844 -18.583 28.361  1.00 126.06 ? 15  GLN B CG    1 
ATOM   1823 C  CD    . GLN B 1 97  ? 62.146 -18.401 29.694  1.00 134.33 ? 15  GLN B CD    1 
ATOM   1824 O  OE1   . GLN B 1 97  ? 61.426 -17.420 29.920  1.00 123.81 ? 15  GLN B OE1   1 
ATOM   1825 N  NE2   . GLN B 1 97  ? 62.374 -19.337 30.603  1.00 148.28 ? 15  GLN B NE2   1 
ATOM   1826 N  N     . ALA B 1 98  ? 60.456 -18.871 25.868  1.00 92.82  ? 16  ALA B N     1 
ATOM   1827 C  CA    . ALA B 1 98  ? 59.658 -17.789 25.309  1.00 86.52  ? 16  ALA B CA    1 
ATOM   1828 C  C     . ALA B 1 98  ? 58.178 -18.169 25.238  1.00 81.20  ? 16  ALA B C     1 
ATOM   1829 O  O     . ALA B 1 98  ? 57.317 -17.316 25.446  1.00 76.84  ? 16  ALA B O     1 
ATOM   1830 C  CB    . ALA B 1 98  ? 60.193 -17.401 23.952  1.00 88.23  ? 16  ALA B CB    1 
ATOM   1831 N  N     . LEU B 1 99  ? 57.872 -19.443 24.949  1.00 79.28  ? 17  LEU B N     1 
ATOM   1832 C  CA    . LEU B 1 99  ? 56.488 -19.901 24.957  1.00 88.36  ? 17  LEU B CA    1 
ATOM   1833 C  C     . LEU B 1 99  ? 55.917 -19.840 26.382  1.00 99.61  ? 17  LEU B C     1 
ATOM   1834 O  O     . LEU B 1 99  ? 54.858 -19.233 26.588  1.00 96.07  ? 17  LEU B O     1 
ATOM   1835 C  CB    . LEU B 1 99  ? 56.370 -21.307 24.360  1.00 92.18  ? 17  LEU B CB    1 
ATOM   1836 C  CG    . LEU B 1 99  ? 56.757 -21.466 22.884  1.00 84.09  ? 17  LEU B CG    1 
ATOM   1837 C  CD1   . LEU B 1 99  ? 56.862 -22.908 22.427  1.00 74.47  ? 17  LEU B CD1   1 
ATOM   1838 C  CD2   . LEU B 1 99  ? 55.751 -20.719 22.046  1.00 90.50  ? 17  LEU B CD2   1 
ATOM   1839 N  N     . VAL B 1 100 ? 56.627 -20.451 27.356  1.00 93.95  ? 18  VAL B N     1 
ATOM   1840 C  CA    . VAL B 1 100 ? 56.182 -20.501 28.748  1.00 106.19 ? 18  VAL B CA    1 
ATOM   1841 C  C     . VAL B 1 100 ? 55.876 -19.073 29.220  1.00 113.53 ? 18  VAL B C     1 
ATOM   1842 O  O     . VAL B 1 100 ? 54.758 -18.795 29.658  1.00 108.68 ? 18  VAL B O     1 
ATOM   1843 C  CB    . VAL B 1 100 ? 57.184 -21.223 29.687  1.00 107.92 ? 18  VAL B CB    1 
ATOM   1844 C  CG1   . VAL B 1 100 ? 57.003 -20.834 31.155  1.00 106.60 ? 18  VAL B CG1   1 
ATOM   1845 C  CG2   . VAL B 1 100 ? 57.139 -22.748 29.551  1.00 94.31  ? 18  VAL B CG2   1 
ATOM   1846 N  N     . ALA B 1 101 ? 56.868 -18.174 29.078  1.00 108.41 ? 19  ALA B N     1 
ATOM   1847 C  CA    . ALA B 1 101 ? 56.767 -16.771 29.470  1.00 97.64  ? 19  ALA B CA    1 
ATOM   1848 C  C     . ALA B 1 101 ? 55.721 -16.006 28.649  1.00 86.74  ? 19  ALA B C     1 
ATOM   1849 O  O     . ALA B 1 101 ? 55.238 -14.968 29.084  1.00 80.43  ? 19  ALA B O     1 
ATOM   1850 C  CB    . ALA B 1 101 ? 58.132 -16.118 29.341  1.00 93.33  ? 19  ALA B CB    1 
ATOM   1851 N  N     . ARG B 1 102 ? 55.392 -16.507 27.452  1.00 89.48  ? 20  ARG B N     1 
ATOM   1852 C  CA    . ARG B 1 102 ? 54.476 -15.845 26.536  1.00 86.10  ? 20  ARG B CA    1 
ATOM   1853 C  C     . ARG B 1 102 ? 55.105 -14.538 26.052  1.00 77.11  ? 20  ARG B C     1 
ATOM   1854 O  O     . ARG B 1 102 ? 54.423 -13.519 25.923  1.00 84.14  ? 20  ARG B O     1 
ATOM   1855 C  CB    . ARG B 1 102 ? 53.081 -15.672 27.156  1.00 89.29  ? 20  ARG B CB    1 
ATOM   1856 C  CG    . ARG B 1 102 ? 52.359 -16.994 27.384  1.00 90.78  ? 20  ARG B CG    1 
ATOM   1857 C  CD    . ARG B 1 102 ? 50.861 -16.806 27.272  1.00 91.91  ? 20  ARG B CD    1 
ATOM   1858 N  NE    . ARG B 1 102 ? 50.113 -18.065 27.182  1.00 99.27  ? 20  ARG B NE    1 
ATOM   1859 C  CZ    . ARG B 1 102 ? 48.813 -18.143 26.859  1.00 99.40  ? 20  ARG B CZ    1 
ATOM   1860 N  NH1   . ARG B 1 102 ? 48.127 -17.050 26.539  1.00 84.23  ? 20  ARG B NH1   1 
ATOM   1861 N  NH2   . ARG B 1 102 ? 48.205 -19.321 26.837  1.00 91.70  ? 20  ARG B NH2   1 
ATOM   1862 N  N     . ASP B 1 103 ? 56.409 -14.598 25.754  1.00 73.01  ? 21  ASP B N     1 
ATOM   1863 C  CA    . ASP B 1 103 ? 57.186 -13.439 25.340  1.00 72.11  ? 21  ASP B CA    1 
ATOM   1864 C  C     . ASP B 1 103 ? 56.965 -13.201 23.844  1.00 72.84  ? 21  ASP B C     1 
ATOM   1865 O  O     . ASP B 1 103 ? 57.777 -13.570 22.990  1.00 71.67  ? 21  ASP B O     1 
ATOM   1866 C  CB    . ASP B 1 103 ? 58.652 -13.595 25.709  1.00 68.13  ? 21  ASP B CB    1 
ATOM   1867 C  CG    . ASP B 1 103 ? 59.542 -12.420 25.333  1.00 66.73  ? 21  ASP B CG    1 
ATOM   1868 O  OD1   . ASP B 1 103 ? 59.016 -11.282 25.203  1.00 63.22  ? 21  ASP B OD1   1 
ATOM   1869 O  OD2   . ASP B 1 103 ? 60.749 -12.670 25.144  1.00 66.68  ? 21  ASP B OD2   1 
ATOM   1870 N  N     . TRP B 1 104 ? 55.835 -12.560 23.550  1.00 69.01  ? 22  TRP B N     1 
ATOM   1871 C  CA    . TRP B 1 104 ? 55.456 -12.194 22.199  1.00 70.56  ? 22  TRP B CA    1 
ATOM   1872 C  C     . TRP B 1 104 ? 56.682 -11.715 21.410  1.00 67.51  ? 22  TRP B C     1 
ATOM   1873 O  O     . TRP B 1 104 ? 56.964 -12.234 20.340  1.00 64.63  ? 22  TRP B O     1 
ATOM   1874 C  CB    . TRP B 1 104 ? 54.331 -11.153 22.283  1.00 68.03  ? 22  TRP B CB    1 
ATOM   1875 C  CG    . TRP B 1 104 ? 53.142 -11.599 23.101  1.00 79.92  ? 22  TRP B CG    1 
ATOM   1876 C  CD1   . TRP B 1 104 ? 52.581 -10.938 24.151  1.00 86.56  ? 22  TRP B CD1   1 
ATOM   1877 C  CD2   . TRP B 1 104 ? 52.334 -12.785 22.913  1.00 85.24  ? 22  TRP B CD2   1 
ATOM   1878 N  NE1   . TRP B 1 104 ? 51.503 -11.628 24.641  1.00 85.54  ? 22  TRP B NE1   1 
ATOM   1879 C  CE2   . TRP B 1 104 ? 51.326 -12.762 23.903  1.00 85.15  ? 22  TRP B CE2   1 
ATOM   1880 C  CE3   . TRP B 1 104 ? 52.367 -13.860 22.014  1.00 77.67  ? 22  TRP B CE3   1 
ATOM   1881 C  CZ2   . TRP B 1 104 ? 50.366 -13.764 24.017  1.00 91.21  ? 22  TRP B CZ2   1 
ATOM   1882 C  CZ3   . TRP B 1 104 ? 51.420 -14.853 22.130  1.00 78.82  ? 22  TRP B CZ3   1 
ATOM   1883 C  CH2   . TRP B 1 104 ? 50.429 -14.799 23.111  1.00 85.94  ? 22  TRP B CH2   1 
ATOM   1884 N  N     . ALA B 1 105 ? 57.442 -10.768 21.967  1.00 66.21  ? 23  ALA B N     1 
ATOM   1885 C  CA    . ALA B 1 105 ? 58.588 -10.190 21.290  1.00 66.18  ? 23  ALA B CA    1 
ATOM   1886 C  C     . ALA B 1 105 ? 59.497 -11.301 20.773  1.00 65.49  ? 23  ALA B C     1 
ATOM   1887 O  O     . ALA B 1 105 ? 59.886 -11.318 19.596  1.00 62.11  ? 23  ALA B O     1 
ATOM   1888 C  CB    . ALA B 1 105 ? 59.332 -9.243  22.227  1.00 70.42  ? 23  ALA B CB    1 
ATOM   1889 N  N     . ALA B 1 106 ? 59.854 -12.237 21.658  1.00 64.51  ? 24  ALA B N     1 
ATOM   1890 C  CA    . ALA B 1 106 ? 60.750 -13.307 21.239  1.00 70.77  ? 24  ALA B CA    1 
ATOM   1891 C  C     . ALA B 1 106 ? 60.118 -14.113 20.099  1.00 72.33  ? 24  ALA B C     1 
ATOM   1892 O  O     . ALA B 1 106 ? 60.811 -14.487 19.147  1.00 75.16  ? 24  ALA B O     1 
ATOM   1893 C  CB    . ALA B 1 106 ? 61.126 -14.184 22.414  1.00 69.00  ? 24  ALA B CB    1 
ATOM   1894 N  N     . LEU B 1 107 ? 58.801 -14.361 20.204  1.00 60.97  ? 25  LEU B N     1 
ATOM   1895 C  CA    . LEU B 1 107 ? 58.072 -15.162 19.231  1.00 66.46  ? 25  LEU B CA    1 
ATOM   1896 C  C     . LEU B 1 107 ? 57.943 -14.393 17.911  1.00 64.59  ? 25  LEU B C     1 
ATOM   1897 O  O     . LEU B 1 107 ? 58.123 -14.986 16.852  1.00 60.36  ? 25  LEU B O     1 
ATOM   1898 C  CB    . LEU B 1 107 ? 56.704 -15.572 19.786  1.00 72.59  ? 25  LEU B CB    1 
ATOM   1899 C  CG    . LEU B 1 107 ? 56.686 -16.367 21.103  1.00 74.17  ? 25  LEU B CG    1 
ATOM   1900 C  CD1   . LEU B 1 107 ? 55.254 -16.698 21.458  1.00 78.31  ? 25  LEU B CD1   1 
ATOM   1901 C  CD2   . LEU B 1 107 ? 57.502 -17.653 21.118  1.00 75.05  ? 25  LEU B CD2   1 
ATOM   1902 N  N     . GLN B 1 108 ? 57.625 -13.088 17.990  1.00 60.24  ? 26  GLN B N     1 
ATOM   1903 C  CA    . GLN B 1 108 ? 57.588 -12.196 16.838  1.00 55.68  ? 26  GLN B CA    1 
ATOM   1904 C  C     . GLN B 1 108 ? 58.921 -12.255 16.092  1.00 60.11  ? 26  GLN B C     1 
ATOM   1905 O  O     . GLN B 1 108 ? 58.963 -12.405 14.866  1.00 60.61  ? 26  GLN B O     1 
ATOM   1906 C  CB    . GLN B 1 108 ? 57.244 -10.765 17.254  1.00 48.11  ? 26  GLN B CB    1 
ATOM   1907 C  CG    . GLN B 1 108 ? 55.817 -10.617 17.768  1.00 52.46  ? 26  GLN B CG    1 
ATOM   1908 C  CD    . GLN B 1 108 ? 55.491 -9.283  18.397  1.00 54.07  ? 26  GLN B CD    1 
ATOM   1909 O  OE1   . GLN B 1 108 ? 56.273 -8.335  18.399  1.00 65.16  ? 26  GLN B OE1   1 
ATOM   1910 N  NE2   . GLN B 1 108 ? 54.294 -9.176  18.939  1.00 60.62  ? 26  GLN B NE2   1 
ATOM   1911 N  N     . ALA B 1 109 ? 60.013 -12.194 16.850  1.00 59.31  ? 27  ALA B N     1 
ATOM   1912 C  CA    . ALA B 1 109 ? 61.331 -12.126 16.243  1.00 65.46  ? 27  ALA B CA    1 
ATOM   1913 C  C     . ALA B 1 109 ? 61.655 -13.436 15.517  1.00 65.13  ? 27  ALA B C     1 
ATOM   1914 O  O     . ALA B 1 109 ? 62.313 -13.420 14.475  1.00 58.17  ? 27  ALA B O     1 
ATOM   1915 C  CB    . ALA B 1 109 ? 62.376 -11.774 17.295  1.00 59.04  ? 27  ALA B CB    1 
ATOM   1916 N  N     . ARG B 1 110 ? 61.229 -14.580 16.071  1.00 60.76  ? 28  ARG B N     1 
ATOM   1917 C  CA    . ARG B 1 110 ? 61.560 -15.864 15.458  1.00 63.78  ? 28  ARG B CA    1 
ATOM   1918 C  C     . ARG B 1 110 ? 60.714 -16.097 14.202  1.00 54.11  ? 28  ARG B C     1 
ATOM   1919 O  O     . ARG B 1 110 ? 61.227 -16.581 13.195  1.00 51.60  ? 28  ARG B O     1 
ATOM   1920 C  CB    . ARG B 1 110 ? 61.432 -16.999 16.480  1.00 74.20  ? 28  ARG B CB    1 
ATOM   1921 C  CG    . ARG B 1 110 ? 62.518 -16.953 17.548  1.00 86.39  ? 28  ARG B CG    1 
ATOM   1922 C  CD    . ARG B 1 110 ? 62.281 -17.952 18.672  1.00 93.89  ? 28  ARG B CD    1 
ATOM   1923 N  NE    . ARG B 1 110 ? 62.930 -17.615 19.947  1.00 100.30 ? 28  ARG B NE    1 
ATOM   1924 C  CZ    . ARG B 1 110 ? 63.920 -18.297 20.514  1.00 97.04  ? 28  ARG B CZ    1 
ATOM   1925 N  NH1   . ARG B 1 110 ? 64.568 -19.223 19.823  1.00 98.64  ? 28  ARG B NH1   1 
ATOM   1926 N  NH2   . ARG B 1 110 ? 64.282 -18.023 21.759  1.00 92.96  ? 28  ARG B NH2   1 
ATOM   1927 N  N     . TYR B 1 111 ? 59.435 -15.709 14.247  1.00 47.74  ? 29  TYR B N     1 
ATOM   1928 C  CA    . TYR B 1 111 ? 58.587 -15.752 13.071  1.00 53.56  ? 29  TYR B CA    1 
ATOM   1929 C  C     . TYR B 1 111 ? 59.209 -14.919 11.943  1.00 57.03  ? 29  TYR B C     1 
ATOM   1930 O  O     . TYR B 1 111 ? 59.402 -15.416 10.831  1.00 53.59  ? 29  TYR B O     1 
ATOM   1931 C  CB    . TYR B 1 111 ? 57.141 -15.326 13.359  1.00 54.61  ? 29  TYR B CB    1 
ATOM   1932 C  CG    . TYR B 1 111 ? 56.292 -15.688 12.148  1.00 57.82  ? 29  TYR B CG    1 
ATOM   1933 C  CD1   . TYR B 1 111 ? 55.939 -17.012 11.889  1.00 57.10  ? 29  TYR B CD1   1 
ATOM   1934 C  CD2   . TYR B 1 111 ? 55.962 -14.742 11.196  1.00 54.83  ? 29  TYR B CD2   1 
ATOM   1935 C  CE1   . TYR B 1 111 ? 55.233 -17.371 10.752  1.00 54.35  ? 29  TYR B CE1   1 
ATOM   1936 C  CE2   . TYR B 1 111 ? 55.240 -15.080 10.066  1.00 57.49  ? 29  TYR B CE2   1 
ATOM   1937 C  CZ    . TYR B 1 111 ? 54.877 -16.397 9.838   1.00 55.46  ? 29  TYR B CZ    1 
ATOM   1938 O  OH    . TYR B 1 111 ? 54.202 -16.722 8.700   1.00 50.21  ? 29  TYR B OH    1 
ATOM   1939 N  N     . TYR B 1 112 ? 59.526 -13.648 12.238  1.00 56.86  ? 30  TYR B N     1 
ATOM   1940 C  CA    . TYR B 1 112 ? 60.128 -12.754 11.260  1.00 51.09  ? 30  TYR B CA    1 
ATOM   1941 C  C     . TYR B 1 112 ? 61.353 -13.430 10.633  1.00 54.29  ? 30  TYR B C     1 
ATOM   1942 O  O     . TYR B 1 112 ? 61.435 -13.504 9.408   1.00 60.32  ? 30  TYR B O     1 
ATOM   1943 C  CB    . TYR B 1 112 ? 60.378 -11.420 11.970  1.00 50.97  ? 30  TYR B CB    1 
ATOM   1944 C  CG    . TYR B 1 112 ? 61.068 -10.327 11.159  1.00 53.73  ? 30  TYR B CG    1 
ATOM   1945 C  CD1   . TYR B 1 112 ? 62.419 -10.415 10.835  1.00 53.65  ? 30  TYR B CD1   1 
ATOM   1946 C  CD2   . TYR B 1 112 ? 60.385 -9.197  10.722  1.00 54.87  ? 30  TYR B CD2   1 
ATOM   1947 C  CE1   . TYR B 1 112 ? 63.062 -9.421  10.116  1.00 52.33  ? 30  TYR B CE1   1 
ATOM   1948 C  CE2   . TYR B 1 112 ? 61.022 -8.189  10.004  1.00 54.84  ? 30  TYR B CE2   1 
ATOM   1949 C  CZ    . TYR B 1 112 ? 62.365 -8.298  9.708   1.00 53.80  ? 30  TYR B CZ    1 
ATOM   1950 O  OH    . TYR B 1 112 ? 63.021 -7.345  8.988   1.00 56.90  ? 30  TYR B OH    1 
ATOM   1951 N  N     . GLU B 1 113 ? 62.284 -13.944 11.459  1.00 51.65  ? 31  GLU B N     1 
ATOM   1952 C  CA    . GLU B 1 113 ? 63.493 -14.605 10.981  1.00 54.13  ? 31  GLU B CA    1 
ATOM   1953 C  C     . GLU B 1 113 ? 63.142 -15.706 9.987   1.00 54.64  ? 31  GLU B C     1 
ATOM   1954 O  O     . GLU B 1 113 ? 63.798 -15.840 8.963   1.00 56.65  ? 31  GLU B O     1 
ATOM   1955 C  CB    . GLU B 1 113 ? 64.354 -15.279 12.049  1.00 61.50  ? 31  GLU B CB    1 
ATOM   1956 C  CG    . GLU B 1 113 ? 65.291 -14.339 12.809  1.00 77.85  ? 31  GLU B CG    1 
ATOM   1957 C  CD    . GLU B 1 113 ? 65.725 -14.830 14.195  1.00 95.26  ? 31  GLU B CD    1 
ATOM   1958 O  OE1   . GLU B 1 113 ? 65.389 -15.985 14.574  1.00 90.92  ? 31  GLU B OE1   1 
ATOM   1959 O  OE2   . GLU B 1 113 ? 66.383 -14.046 14.922  1.00 96.25  ? 31  GLU B OE2   1 
ATOM   1960 N  N     . ALA B 1 114 ? 62.108 -16.487 10.295  1.00 51.32  ? 32  ALA B N     1 
ATOM   1961 C  CA    . ALA B 1 114 ? 61.694 -17.570 9.420   1.00 52.25  ? 32  ALA B CA    1 
ATOM   1962 C  C     . ALA B 1 114 ? 61.050 -17.016 8.149   1.00 49.47  ? 32  ALA B C     1 
ATOM   1963 O  O     . ALA B 1 114 ? 61.405 -17.399 7.037   1.00 57.65  ? 32  ALA B O     1 
ATOM   1964 C  CB    . ALA B 1 114 ? 60.752 -18.491 10.165  1.00 52.63  ? 32  ALA B CB    1 
ATOM   1965 N  N     . ALA B 1 115 ? 60.119 -16.085 8.318   1.00 46.32  ? 33  ALA B N     1 
ATOM   1966 C  CA    . ALA B 1 115 ? 59.387 -15.532 7.199   1.00 44.08  ? 33  ALA B CA    1 
ATOM   1967 C  C     . ALA B 1 115 ? 60.291 -14.874 6.157   1.00 43.29  ? 33  ALA B C     1 
ATOM   1968 O  O     . ALA B 1 115 ? 60.126 -15.142 4.980   1.00 44.92  ? 33  ALA B O     1 
ATOM   1969 C  CB    . ALA B 1 115 ? 58.370 -14.573 7.728   1.00 47.44  ? 33  ALA B CB    1 
ATOM   1970 N  N     . VAL B 1 116 ? 61.244 -14.016 6.551   1.00 45.11  ? 34  VAL B N     1 
ATOM   1971 C  CA    . VAL B 1 116 ? 62.022 -13.273 5.563   1.00 42.33  ? 34  VAL B CA    1 
ATOM   1972 C  C     . VAL B 1 116 ? 63.095 -14.179 4.964   1.00 47.25  ? 34  VAL B C     1 
ATOM   1973 O  O     . VAL B 1 116 ? 63.661 -13.871 3.923   1.00 50.69  ? 34  VAL B O     1 
ATOM   1974 C  CB    . VAL B 1 116 ? 62.630 -11.983 6.140   1.00 49.34  ? 34  VAL B CB    1 
ATOM   1975 C  CG1   . VAL B 1 116 ? 61.554 -11.041 6.674   1.00 52.86  ? 34  VAL B CG1   1 
ATOM   1976 C  CG2   . VAL B 1 116 ? 63.660 -12.248 7.223   1.00 48.36  ? 34  VAL B CG2   1 
ATOM   1977 N  N     . ALA B 1 117 ? 63.370 -15.317 5.612   1.00 46.74  ? 35  ALA B N     1 
ATOM   1978 C  CA    . ALA B 1 117 ? 64.238 -16.333 5.034   1.00 47.68  ? 35  ALA B CA    1 
ATOM   1979 C  C     . ALA B 1 117 ? 63.481 -17.214 4.025   1.00 51.42  ? 35  ALA B C     1 
ATOM   1980 O  O     . ALA B 1 117 ? 64.084 -17.983 3.288   1.00 50.61  ? 35  ALA B O     1 
ATOM   1981 C  CB    . ALA B 1 117 ? 64.853 -17.139 6.154   1.00 42.47  ? 35  ALA B CB    1 
ATOM   1982 N  N     . GLY B 1 118 ? 62.155 -17.100 3.964   1.00 50.27  ? 36  GLY B N     1 
ATOM   1983 C  CA    . GLY B 1 118 ? 61.373 -17.912 3.054   1.00 50.31  ? 36  GLY B CA    1 
ATOM   1984 C  C     . GLY B 1 118 ? 61.273 -19.354 3.546   1.00 52.32  ? 36  GLY B C     1 
ATOM   1985 O  O     . GLY B 1 118 ? 61.088 -20.257 2.745   1.00 56.63  ? 36  GLY B O     1 
ATOM   1986 N  N     . ASP B 1 119 ? 61.371 -19.557 4.866   1.00 51.44  ? 37  ASP B N     1 
ATOM   1987 C  CA    . ASP B 1 119 ? 61.387 -20.878 5.472   1.00 51.93  ? 37  ASP B CA    1 
ATOM   1988 C  C     . ASP B 1 119 ? 60.021 -21.239 6.056   1.00 54.57  ? 37  ASP B C     1 
ATOM   1989 O  O     . ASP B 1 119 ? 59.744 -20.973 7.227   1.00 47.63  ? 37  ASP B O     1 
ATOM   1990 C  CB    . ASP B 1 119 ? 62.436 -20.933 6.563   1.00 61.91  ? 37  ASP B CB    1 
ATOM   1991 C  CG    . ASP B 1 119 ? 62.826 -22.323 7.017   1.00 65.25  ? 37  ASP B CG    1 
ATOM   1992 O  OD1   . ASP B 1 119 ? 62.019 -23.272 6.796   1.00 66.58  ? 37  ASP B OD1   1 
ATOM   1993 O  OD2   . ASP B 1 119 ? 63.945 -22.419 7.559   1.00 65.67  ? 37  ASP B OD2   1 
ATOM   1994 N  N     . GLU B 1 120 ? 59.207 -21.912 5.233   1.00 54.76  ? 38  GLU B N     1 
ATOM   1995 C  CA    . GLU B 1 120 ? 57.847 -22.288 5.581   1.00 55.27  ? 38  GLU B CA    1 
ATOM   1996 C  C     . GLU B 1 120 ? 57.844 -23.274 6.758   1.00 54.04  ? 38  GLU B C     1 
ATOM   1997 O  O     . GLU B 1 120 ? 57.035 -23.135 7.673   1.00 46.04  ? 38  GLU B O     1 
ATOM   1998 C  CB    . GLU B 1 120 ? 57.252 -22.708 4.236   1.00 61.85  ? 38  GLU B CB    1 
ATOM   1999 C  CG    . GLU B 1 120 ? 55.841 -23.266 4.339   1.00 77.79  ? 38  GLU B CG    1 
ATOM   2000 C  CD    . GLU B 1 120 ? 55.782 -24.771 4.174   1.00 102.80 ? 38  GLU B CD    1 
ATOM   2001 O  OE1   . GLU B 1 120 ? 56.567 -25.256 3.309   1.00 86.41  ? 38  GLU B OE1   1 
ATOM   2002 O  OE2   . GLU B 1 120 ? 54.946 -25.429 4.863   1.00 116.33 ? 38  GLU B OE2   1 
ATOM   2003 N  N     . LEU B 1 121 ? 58.801 -24.218 6.792   1.00 53.37  ? 39  LEU B N     1 
ATOM   2004 C  CA    . LEU B 1 121 ? 58.814 -25.266 7.810   1.00 50.72  ? 39  LEU B CA    1 
ATOM   2005 C  C     . LEU B 1 121 ? 59.095 -24.676 9.194   1.00 52.03  ? 39  LEU B C     1 
ATOM   2006 O  O     . LEU B 1 121 ? 58.328 -24.916 10.130  1.00 46.84  ? 39  LEU B O     1 
ATOM   2007 C  CB    . LEU B 1 121 ? 59.788 -26.386 7.427   1.00 50.31  ? 39  LEU B CB    1 
ATOM   2008 C  CG    . LEU B 1 121 ? 59.436 -27.122 6.120   1.00 58.54  ? 39  LEU B CG    1 
ATOM   2009 C  CD1   . LEU B 1 121 ? 60.445 -28.191 5.757   1.00 62.47  ? 39  LEU B CD1   1 
ATOM   2010 C  CD2   . LEU B 1 121 ? 58.020 -27.723 6.107   1.00 53.03  ? 39  LEU B CD2   1 
ATOM   2011 N  N     . ALA B 1 122 ? 60.133 -23.832 9.314   1.00 50.12  ? 40  ALA B N     1 
ATOM   2012 C  CA    . ALA B 1 122 ? 60.397 -23.157 10.582  1.00 49.98  ? 40  ALA B CA    1 
ATOM   2013 C  C     . ALA B 1 122 ? 59.183 -22.347 11.040  1.00 48.87  ? 40  ALA B C     1 
ATOM   2014 O  O     . ALA B 1 122 ? 58.863 -22.292 12.228  1.00 50.55  ? 40  ALA B O     1 
ATOM   2015 C  CB    . ALA B 1 122 ? 61.616 -22.289 10.449  1.00 57.71  ? 40  ALA B CB    1 
ATOM   2016 N  N     . GLY B 1 123 ? 58.477 -21.739 10.080  1.00 49.22  ? 41  GLY B N     1 
ATOM   2017 C  CA    . GLY B 1 123 ? 57.359 -20.877 10.404  1.00 44.97  ? 41  GLY B CA    1 
ATOM   2018 C  C     . GLY B 1 123 ? 56.219 -21.664 11.024  1.00 53.15  ? 41  GLY B C     1 
ATOM   2019 O  O     . GLY B 1 123 ? 55.646 -21.218 12.025  1.00 52.80  ? 41  GLY B O     1 
ATOM   2020 N  N     . VAL B 1 124 ? 55.903 -22.816 10.400  1.00 52.40  ? 42  VAL B N     1 
ATOM   2021 C  CA    . VAL B 1 124 ? 54.844 -23.698 10.877  1.00 52.28  ? 42  VAL B CA    1 
ATOM   2022 C  C     . VAL B 1 124 ? 55.272 -24.306 12.210  1.00 48.24  ? 42  VAL B C     1 
ATOM   2023 O  O     . VAL B 1 124 ? 54.485 -24.344 13.143  1.00 46.81  ? 42  VAL B O     1 
ATOM   2024 C  CB    . VAL B 1 124 ? 54.469 -24.836 9.909   1.00 62.63  ? 42  VAL B CB    1 
ATOM   2025 C  CG1   . VAL B 1 124 ? 53.323 -25.692 10.449  1.00 64.37  ? 42  VAL B CG1   1 
ATOM   2026 C  CG2   . VAL B 1 124 ? 54.107 -24.303 8.535   1.00 70.68  ? 42  VAL B CG2   1 
ATOM   2027 N  N     . ALA B 1 125 ? 56.508 -24.812 12.268  1.00 45.70  ? 43  ALA B N     1 
ATOM   2028 C  CA    . ALA B 1 125 ? 57.071 -25.383 13.486  1.00 50.96  ? 43  ALA B CA    1 
ATOM   2029 C  C     . ALA B 1 125 ? 56.799 -24.487 14.688  1.00 57.09  ? 43  ALA B C     1 
ATOM   2030 O  O     . ALA B 1 125 ? 56.232 -24.964 15.677  1.00 62.31  ? 43  ALA B O     1 
ATOM   2031 C  CB    . ALA B 1 125 ? 58.568 -25.612 13.331  1.00 52.96  ? 43  ALA B CB    1 
ATOM   2032 N  N     . LEU B 1 126 ? 57.214 -23.209 14.574  1.00 59.15  ? 44  LEU B N     1 
ATOM   2033 C  CA    . LEU B 1 126 ? 57.100 -22.241 15.653  1.00 58.32  ? 44  LEU B CA    1 
ATOM   2034 C  C     . LEU B 1 126 ? 55.641 -22.109 16.064  1.00 48.84  ? 44  LEU B C     1 
ATOM   2035 O  O     . LEU B 1 126 ? 55.302 -22.194 17.240  1.00 56.43  ? 44  LEU B O     1 
ATOM   2036 C  CB    . LEU B 1 126 ? 57.652 -20.881 15.231  1.00 68.58  ? 44  LEU B CB    1 
ATOM   2037 C  CG    . LEU B 1 126 ? 57.240 -19.715 16.142  1.00 68.17  ? 44  LEU B CG    1 
ATOM   2038 C  CD1   . LEU B 1 126 ? 58.335 -19.381 17.127  1.00 72.19  ? 44  LEU B CD1   1 
ATOM   2039 C  CD2   . LEU B 1 126 ? 56.808 -18.501 15.360  1.00 66.02  ? 44  LEU B CD2   1 
ATOM   2040 N  N     . LEU B 1 127 ? 54.778 -21.873 15.082  1.00 51.93  ? 45  LEU B N     1 
ATOM   2041 C  CA    . LEU B 1 127 ? 53.368 -21.656 15.354  1.00 49.31  ? 45  LEU B CA    1 
ATOM   2042 C  C     . LEU B 1 127 ? 52.739 -22.911 15.965  1.00 54.28  ? 45  LEU B C     1 
ATOM   2043 O  O     . LEU B 1 127 ? 51.905 -22.829 16.867  1.00 65.91  ? 45  LEU B O     1 
ATOM   2044 C  CB    . LEU B 1 127 ? 52.697 -21.288 14.033  1.00 54.65  ? 45  LEU B CB    1 
ATOM   2045 C  CG    . LEU B 1 127 ? 53.033 -19.917 13.435  1.00 53.88  ? 45  LEU B CG    1 
ATOM   2046 C  CD1   . LEU B 1 127 ? 52.321 -19.838 12.117  1.00 53.84  ? 45  LEU B CD1   1 
ATOM   2047 C  CD2   . LEU B 1 127 ? 52.631 -18.740 14.310  1.00 57.03  ? 45  LEU B CD2   1 
ATOM   2048 N  N     . GLU B 1 128 ? 53.120 -24.082 15.448  1.00 57.06  ? 46  GLU B N     1 
ATOM   2049 C  CA    . GLU B 1 128 ? 52.544 -25.343 15.889  1.00 63.37  ? 46  GLU B CA    1 
ATOM   2050 C  C     . GLU B 1 128 ? 52.995 -25.632 17.315  1.00 59.64  ? 46  GLU B C     1 
ATOM   2051 O  O     . GLU B 1 128 ? 52.167 -25.968 18.158  1.00 60.36  ? 46  GLU B O     1 
ATOM   2052 C  CB    . GLU B 1 128 ? 52.912 -26.492 14.952  1.00 68.82  ? 46  GLU B CB    1 
ATOM   2053 C  CG    . GLU B 1 128 ? 51.966 -27.686 15.049  1.00 74.92  ? 46  GLU B CG    1 
ATOM   2054 C  CD    . GLU B 1 128 ? 52.404 -28.845 15.914  1.00 79.50  ? 46  GLU B CD    1 
ATOM   2055 O  OE1   . GLU B 1 128 ? 53.414 -28.752 16.655  1.00 88.99  ? 46  GLU B OE1   1 
ATOM   2056 O  OE2   . GLU B 1 128 ? 51.699 -29.872 15.795  1.00 86.08  ? 46  GLU B OE2   1 
ATOM   2057 N  N     . ARG B 1 129 ? 54.297 -25.468 17.572  1.00 51.47  ? 47  ARG B N     1 
ATOM   2058 C  CA    . ARG B 1 129 ? 54.812 -25.672 18.911  1.00 55.09  ? 47  ARG B CA    1 
ATOM   2059 C  C     . ARG B 1 129 ? 54.104 -24.739 19.882  1.00 62.83  ? 47  ARG B C     1 
ATOM   2060 O  O     . ARG B 1 129 ? 53.641 -25.194 20.920  1.00 63.69  ? 47  ARG B O     1 
ATOM   2061 C  CB    . ARG B 1 129 ? 56.321 -25.486 18.967  1.00 63.17  ? 47  ARG B CB    1 
ATOM   2062 C  CG    . ARG B 1 129 ? 56.894 -26.227 20.161  1.00 74.44  ? 47  ARG B CG    1 
ATOM   2063 C  CD    . ARG B 1 129 ? 58.405 -26.265 20.128  1.00 79.74  ? 47  ARG B CD    1 
ATOM   2064 N  NE    . ARG B 1 129 ? 58.850 -26.998 21.317  1.00 99.61  ? 47  ARG B NE    1 
ATOM   2065 C  CZ    . ARG B 1 129 ? 58.872 -28.324 21.422  1.00 106.64 ? 47  ARG B CZ    1 
ATOM   2066 N  NH1   . ARG B 1 129 ? 58.733 -29.083 20.346  1.00 108.41 ? 47  ARG B NH1   1 
ATOM   2067 N  NH2   . ARG B 1 129 ? 59.096 -28.885 22.594  1.00 103.77 ? 47  ARG B NH2   1 
ATOM   2068 N  N     . ALA B 1 130 ? 53.945 -23.468 19.483  1.00 65.14  ? 48  ALA B N     1 
ATOM   2069 C  CA    . ALA B 1 130 ? 53.326 -22.443 20.311  1.00 62.54  ? 48  ALA B CA    1 
ATOM   2070 C  C     . ALA B 1 130 ? 51.891 -22.802 20.689  1.00 65.10  ? 48  ALA B C     1 
ATOM   2071 O  O     . ALA B 1 130 ? 51.509 -22.645 21.851  1.00 72.70  ? 48  ALA B O     1 
ATOM   2072 C  CB    . ALA B 1 130 ? 53.372 -21.109 19.599  1.00 58.46  ? 48  ALA B CB    1 
ATOM   2073 N  N     . TYR B 1 131 ? 51.096 -23.226 19.694  1.00 67.65  ? 49  TYR B N     1 
ATOM   2074 C  CA    . TYR B 1 131 ? 49.729 -23.693 19.914  1.00 68.11  ? 49  TYR B CA    1 
ATOM   2075 C  C     . TYR B 1 131 ? 49.688 -24.841 20.931  1.00 71.60  ? 49  TYR B C     1 
ATOM   2076 O  O     . TYR B 1 131 ? 48.882 -24.788 21.858  1.00 67.24  ? 49  TYR B O     1 
ATOM   2077 C  CB    . TYR B 1 131 ? 49.106 -24.101 18.576  1.00 65.36  ? 49  TYR B CB    1 
ATOM   2078 C  CG    . TYR B 1 131 ? 47.801 -24.880 18.666  1.00 64.50  ? 49  TYR B CG    1 
ATOM   2079 C  CD1   . TYR B 1 131 ? 46.654 -24.302 19.203  1.00 61.12  ? 49  TYR B CD1   1 
ATOM   2080 C  CD2   . TYR B 1 131 ? 47.712 -26.194 18.193  1.00 64.70  ? 49  TYR B CD2   1 
ATOM   2081 C  CE1   . TYR B 1 131 ? 45.456 -25.003 19.277  1.00 61.05  ? 49  TYR B CE1   1 
ATOM   2082 C  CE2   . TYR B 1 131 ? 46.520 -26.902 18.254  1.00 63.60  ? 49  TYR B CE2   1 
ATOM   2083 C  CZ    . TYR B 1 131 ? 45.393 -26.308 18.805  1.00 66.00  ? 49  TYR B CZ    1 
ATOM   2084 O  OH    . TYR B 1 131 ? 44.214 -27.000 18.845  1.00 70.41  ? 49  TYR B OH    1 
ATOM   2085 N  N     . ARG B 1 132 ? 50.559 -25.855 20.747  1.00 74.14  ? 50  ARG B N     1 
ATOM   2086 C  CA    . ARG B 1 132 ? 50.653 -27.028 21.614  1.00 74.60  ? 50  ARG B CA    1 
ATOM   2087 C  C     . ARG B 1 132 ? 51.376 -26.735 22.930  1.00 79.41  ? 50  ARG B C     1 
ATOM   2088 O  O     . ARG B 1 132 ? 51.605 -27.650 23.711  1.00 75.14  ? 50  ARG B O     1 
ATOM   2089 C  CB    . ARG B 1 132 ? 51.574 -28.123 21.069  1.00 70.46  ? 50  ARG B CB    1 
ATOM   2090 C  CG    . ARG B 1 132 ? 51.252 -28.631 19.680  1.00 76.58  ? 50  ARG B CG    1 
ATOM   2091 C  CD    . ARG B 1 132 ? 50.459 -29.918 19.675  1.00 74.14  ? 50  ARG B CD    1 
ATOM   2092 N  NE    . ARG B 1 132 ? 50.146 -30.174 18.265  1.00 66.03  ? 50  ARG B NE    1 
ATOM   2093 C  CZ    . ARG B 1 132 ? 48.923 -30.201 17.766  1.00 64.63  ? 50  ARG B CZ    1 
ATOM   2094 N  NH1   . ARG B 1 132 ? 47.892 -30.273 18.603  1.00 62.23  ? 50  ARG B NH1   1 
ATOM   2095 N  NH2   . ARG B 1 132 ? 48.758 -30.209 16.447  1.00 62.67  ? 50  ARG B NH2   1 
ATOM   2096 N  N     . SER B 1 133 ? 51.848 -25.500 23.117  1.00 79.24  ? 51  SER B N     1 
ATOM   2097 C  CA    . SER B 1 133 ? 52.318 -25.044 24.410  1.00 71.79  ? 51  SER B CA    1 
ATOM   2098 C  C     . SER B 1 133 ? 51.183 -24.324 25.141  1.00 72.32  ? 51  SER B C     1 
ATOM   2099 O  O     . SER B 1 133 ? 51.396 -23.863 26.260  1.00 93.67  ? 51  SER B O     1 
ATOM   2100 C  CB    . SER B 1 133 ? 53.510 -24.129 24.273  1.00 70.83  ? 51  SER B CB    1 
ATOM   2101 O  OG    . SER B 1 133 ? 53.086 -22.772 24.171  1.00 68.75  ? 51  SER B OG    1 
ATOM   2102 N  N     . GLY B 1 134 ? 50.014 -24.168 24.499  1.00 55.24  ? 52  GLY B N     1 
ATOM   2103 C  CA    . GLY B 1 134 ? 48.820 -23.708 25.195  1.00 57.29  ? 52  GLY B CA    1 
ATOM   2104 C  C     . GLY B 1 134 ? 48.251 -22.399 24.651  1.00 70.98  ? 52  GLY B C     1 
ATOM   2105 O  O     . GLY B 1 134 ? 47.221 -21.921 25.139  1.00 68.32  ? 52  GLY B O     1 
ATOM   2106 N  N     . ILE B 1 135 ? 48.905 -21.814 23.634  1.00 78.17  ? 53  ILE B N     1 
ATOM   2107 C  CA    . ILE B 1 135 ? 48.474 -20.523 23.111  1.00 65.07  ? 53  ILE B CA    1 
ATOM   2108 C  C     . ILE B 1 135 ? 47.418 -20.755 22.035  1.00 56.86  ? 53  ILE B C     1 
ATOM   2109 O  O     . ILE B 1 135 ? 47.699 -21.388 21.029  1.00 59.31  ? 53  ILE B O     1 
ATOM   2110 C  CB    . ILE B 1 135 ? 49.664 -19.711 22.560  1.00 61.87  ? 53  ILE B CB    1 
ATOM   2111 C  CG1   . ILE B 1 135 ? 50.772 -19.551 23.594  1.00 58.51  ? 53  ILE B CG1   1 
ATOM   2112 C  CG2   . ILE B 1 135 ? 49.187 -18.354 22.046  1.00 62.99  ? 53  ILE B CG2   1 
ATOM   2113 C  CD1   . ILE B 1 135 ? 52.132 -19.171 23.030  1.00 60.64  ? 53  ILE B CD1   1 
ATOM   2114 N  N     . PRO B 1 136 ? 46.199 -20.190 22.160  1.00 57.50  ? 54  PRO B N     1 
ATOM   2115 C  CA    . PRO B 1 136 ? 45.227 -20.255 21.070  1.00 58.65  ? 54  PRO B CA    1 
ATOM   2116 C  C     . PRO B 1 136 ? 45.836 -19.730 19.768  1.00 64.26  ? 54  PRO B C     1 
ATOM   2117 O  O     . PRO B 1 136 ? 46.715 -18.877 19.793  1.00 61.60  ? 54  PRO B O     1 
ATOM   2118 C  CB    . PRO B 1 136 ? 44.050 -19.370 21.543  1.00 56.79  ? 54  PRO B CB    1 
ATOM   2119 C  CG    . PRO B 1 136 ? 44.248 -19.178 23.033  1.00 56.00  ? 54  PRO B CG    1 
ATOM   2120 C  CD    . PRO B 1 136 ? 45.722 -19.407 23.312  1.00 55.49  ? 54  PRO B CD    1 
ATOM   2121 N  N     . VAL B 1 137 ? 45.317 -20.197 18.625  1.00 68.48  ? 55  VAL B N     1 
ATOM   2122 C  CA    . VAL B 1 137 ? 45.765 -19.748 17.310  1.00 60.70  ? 55  VAL B CA    1 
ATOM   2123 C  C     . VAL B 1 137 ? 45.414 -18.270 17.092  1.00 62.40  ? 55  VAL B C     1 
ATOM   2124 O  O     . VAL B 1 137 ? 46.222 -17.504 16.565  1.00 64.18  ? 55  VAL B O     1 
ATOM   2125 C  CB    . VAL B 1 137 ? 45.141 -20.654 16.232  1.00 53.01  ? 55  VAL B CB    1 
ATOM   2126 C  CG1   . VAL B 1 137 ? 45.430 -20.178 14.819  1.00 54.48  ? 55  VAL B CG1   1 
ATOM   2127 C  CG2   . VAL B 1 137 ? 45.605 -22.093 16.397  1.00 62.33  ? 55  VAL B CG2   1 
ATOM   2128 N  N     . VAL B 1 138 ? 44.203 -17.872 17.503  1.00 57.67  ? 56  VAL B N     1 
ATOM   2129 C  CA    . VAL B 1 138 ? 43.750 -16.494 17.405  1.00 60.72  ? 56  VAL B CA    1 
ATOM   2130 C  C     . VAL B 1 138 ? 44.795 -15.568 18.035  1.00 60.72  ? 56  VAL B C     1 
ATOM   2131 O  O     . VAL B 1 138 ? 45.161 -14.568 17.435  1.00 59.26  ? 56  VAL B O     1 
ATOM   2132 C  CB    . VAL B 1 138 ? 42.347 -16.336 18.030  1.00 53.88  ? 56  VAL B CB    1 
ATOM   2133 C  CG1   . VAL B 1 138 ? 41.976 -14.886 18.298  1.00 54.48  ? 56  VAL B CG1   1 
ATOM   2134 C  CG2   . VAL B 1 138 ? 41.282 -16.972 17.145  1.00 52.77  ? 56  VAL B CG2   1 
ATOM   2135 N  N     . ALA B 1 139 ? 45.295 -15.937 19.218  1.00 59.84  ? 57  ALA B N     1 
ATOM   2136 C  CA    . ALA B 1 139 ? 46.303 -15.156 19.908  1.00 58.60  ? 57  ALA B CA    1 
ATOM   2137 C  C     . ALA B 1 139 ? 47.558 -15.082 19.050  1.00 63.16  ? 57  ALA B C     1 
ATOM   2138 O  O     . ALA B 1 139 ? 48.132 -14.008 18.913  1.00 69.69  ? 57  ALA B O     1 
ATOM   2139 C  CB    . ALA B 1 139 ? 46.609 -15.751 21.274  1.00 55.16  ? 57  ALA B CB    1 
ATOM   2140 N  N     . LEU B 1 140 ? 47.988 -16.225 18.492  1.00 63.76  ? 58  LEU B N     1 
ATOM   2141 C  CA    . LEU B 1 140 ? 49.134 -16.254 17.587  1.00 60.77  ? 58  LEU B CA    1 
ATOM   2142 C  C     . LEU B 1 140 ? 48.914 -15.318 16.393  1.00 61.21  ? 58  LEU B C     1 
ATOM   2143 O  O     . LEU B 1 140 ? 49.810 -14.600 15.967  1.00 58.26  ? 58  LEU B O     1 
ATOM   2144 C  CB    . LEU B 1 140 ? 49.395 -17.677 17.113  1.00 58.34  ? 58  LEU B CB    1 
ATOM   2145 C  CG    . LEU B 1 140 ? 49.849 -18.666 18.192  1.00 64.64  ? 58  LEU B CG    1 
ATOM   2146 C  CD1   . LEU B 1 140 ? 50.101 -20.018 17.529  1.00 58.98  ? 58  LEU B CD1   1 
ATOM   2147 C  CD2   . LEU B 1 140 ? 51.070 -18.211 18.995  1.00 59.05  ? 58  LEU B CD2   1 
ATOM   2148 N  N     . LYS B 1 141 ? 47.706 -15.313 15.854  1.00 53.80  ? 59  LYS B N     1 
ATOM   2149 C  CA    . LYS B 1 141 ? 47.421 -14.455 14.730  1.00 61.09  ? 59  LYS B CA    1 
ATOM   2150 C  C     . LYS B 1 141 ? 47.624 -13.003 15.147  1.00 60.68  ? 59  LYS B C     1 
ATOM   2151 O  O     . LYS B 1 141 ? 48.287 -12.264 14.433  1.00 62.63  ? 59  LYS B O     1 
ATOM   2152 C  CB    . LYS B 1 141 ? 46.028 -14.789 14.171  1.00 61.88  ? 59  LYS B CB    1 
ATOM   2153 C  CG    . LYS B 1 141 ? 45.989 -16.166 13.503  1.00 56.16  ? 59  LYS B CG    1 
ATOM   2154 C  CD    . LYS B 1 141 ? 44.625 -16.621 13.012  1.00 58.86  ? 59  LYS B CD    1 
ATOM   2155 C  CE    . LYS B 1 141 ? 44.720 -17.912 12.282  1.00 53.99  ? 59  LYS B CE    1 
ATOM   2156 N  NZ    . LYS B 1 141 ? 43.482 -18.135 11.532  1.00 55.64  ? 59  LYS B NZ    1 
ATOM   2157 N  N     . GLU B 1 142 ? 47.068 -12.616 16.304  1.00 61.16  ? 60  GLU B N     1 
ATOM   2158 C  CA    . GLU B 1 142 ? 46.924 -11.214 16.677  1.00 57.24  ? 60  GLU B CA    1 
ATOM   2159 C  C     . GLU B 1 142 ? 48.208 -10.636 17.284  1.00 51.49  ? 60  GLU B C     1 
ATOM   2160 O  O     . GLU B 1 142 ? 48.517 -9.477  17.052  1.00 53.62  ? 60  GLU B O     1 
ATOM   2161 C  CB    . GLU B 1 142 ? 45.758 -11.058 17.648  1.00 55.05  ? 60  GLU B CB    1 
ATOM   2162 C  CG    . GLU B 1 142 ? 44.420 -10.898 16.942  1.00 58.69  ? 60  GLU B CG    1 
ATOM   2163 C  CD    . GLU B 1 142 ? 43.244 -10.877 17.906  1.00 66.89  ? 60  GLU B CD    1 
ATOM   2164 O  OE1   . GLU B 1 142 ? 43.443 -11.185 19.107  1.00 60.93  ? 60  GLU B OE1   1 
ATOM   2165 O  OE2   . GLU B 1 142 ? 42.129 -10.521 17.450  1.00 65.82  ? 60  GLU B OE2   1 
ATOM   2166 N  N     . HIS B 1 143 ? 48.955 -11.445 18.039  1.00 51.84  ? 61  HIS B N     1 
ATOM   2167 C  CA    . HIS B 1 143 ? 50.108 -10.975 18.791  1.00 53.48  ? 61  HIS B CA    1 
ATOM   2168 C  C     . HIS B 1 143 ? 51.412 -11.530 18.226  1.00 52.80  ? 61  HIS B C     1 
ATOM   2169 O  O     . HIS B 1 143 ? 52.439 -11.305 18.849  1.00 53.89  ? 61  HIS B O     1 
ATOM   2170 C  CB    . HIS B 1 143 ? 49.940 -11.283 20.293  1.00 52.97  ? 61  HIS B CB    1 
ATOM   2171 C  CG    . HIS B 1 143 ? 48.686 -10.638 20.815  1.00 62.26  ? 61  HIS B CG    1 
ATOM   2172 N  ND1   . HIS B 1 143 ? 48.521 -9.264  20.849  1.00 61.42  ? 61  HIS B ND1   1 
ATOM   2173 C  CD2   . HIS B 1 143 ? 47.503 -11.149 21.195  1.00 63.03  ? 61  HIS B CD2   1 
ATOM   2174 C  CE1   . HIS B 1 143 ? 47.302 -8.965  21.275  1.00 57.88  ? 61  HIS B CE1   1 
ATOM   2175 N  NE2   . HIS B 1 143 ? 46.665 -10.096 21.490  1.00 64.68  ? 61  HIS B NE2   1 
ATOM   2176 N  N     . VAL B 1 144 ? 51.390 -12.243 17.082  1.00 52.07  ? 62  VAL B N     1 
ATOM   2177 C  CA    . VAL B 1 144 ? 52.618 -12.740 16.457  1.00 56.19  ? 62  VAL B CA    1 
ATOM   2178 C  C     . VAL B 1 144 ? 52.609 -12.389 14.964  1.00 55.28  ? 62  VAL B C     1 
ATOM   2179 O  O     . VAL B 1 144 ? 53.504 -11.714 14.494  1.00 64.27  ? 62  VAL B O     1 
ATOM   2180 C  CB    . VAL B 1 144 ? 52.912 -14.241 16.708  1.00 56.90  ? 62  VAL B CB    1 
ATOM   2181 C  CG1   . VAL B 1 144 ? 54.256 -14.724 16.153  1.00 53.13  ? 62  VAL B CG1   1 
ATOM   2182 C  CG2   . VAL B 1 144 ? 52.906 -14.582 18.193  1.00 61.94  ? 62  VAL B CG2   1 
ATOM   2183 N  N     . LEU B 1 145 ? 51.579 -12.783 14.220  1.00 52.79  ? 63  LEU B N     1 
ATOM   2184 C  CA    . LEU B 1 145 ? 51.595 -12.677 12.772  1.00 52.68  ? 63  LEU B CA    1 
ATOM   2185 C  C     . LEU B 1 145 ? 51.340 -11.237 12.339  1.00 55.32  ? 63  LEU B C     1 
ATOM   2186 O  O     . LEU B 1 145 ? 52.119 -10.681 11.556  1.00 52.61  ? 63  LEU B O     1 
ATOM   2187 C  CB    . LEU B 1 145 ? 50.570 -13.618 12.136  1.00 52.15  ? 63  LEU B CB    1 
ATOM   2188 C  CG    . LEU B 1 145 ? 50.797 -15.120 12.354  1.00 57.21  ? 63  LEU B CG    1 
ATOM   2189 C  CD1   . LEU B 1 145 ? 49.707 -15.935 11.674  1.00 54.74  ? 63  LEU B CD1   1 
ATOM   2190 C  CD2   . LEU B 1 145 ? 52.167 -15.550 11.857  1.00 58.43  ? 63  LEU B CD2   1 
ATOM   2191 N  N     . THR B 1 146 ? 50.212 -10.681 12.804  1.00 53.01  ? 64  THR B N     1 
ATOM   2192 C  CA    . THR B 1 146 ? 49.826 -9.304  12.523  1.00 54.78  ? 64  THR B CA    1 
ATOM   2193 C  C     . THR B 1 146 ? 50.973 -8.335  12.865  1.00 56.24  ? 64  THR B C     1 
ATOM   2194 O  O     . THR B 1 146 ? 51.394 -7.561  12.000  1.00 48.55  ? 64  THR B O     1 
ATOM   2195 C  CB    . THR B 1 146 ? 48.511 -9.013  13.252  1.00 54.28  ? 64  THR B CB    1 
ATOM   2196 O  OG1   . THR B 1 146 ? 47.560 -9.834  12.581  1.00 49.85  ? 64  THR B OG1   1 
ATOM   2197 C  CG2   . THR B 1 146 ? 48.005 -7.595  13.081  1.00 57.48  ? 64  THR B CG2   1 
ATOM   2198 N  N     . PRO B 1 147 ? 51.548 -8.334  14.096  1.00 56.62  ? 65  PRO B N     1 
ATOM   2199 C  CA    . PRO B 1 147 ? 52.639 -7.417  14.421  1.00 57.20  ? 65  PRO B CA    1 
ATOM   2200 C  C     . PRO B 1 147 ? 53.863 -7.603  13.532  1.00 54.30  ? 65  PRO B C     1 
ATOM   2201 O  O     . PRO B 1 147 ? 54.413 -6.619  13.050  1.00 54.97  ? 65  PRO B O     1 
ATOM   2202 C  CB    . PRO B 1 147 ? 52.955 -7.675  15.919  1.00 64.29  ? 65  PRO B CB    1 
ATOM   2203 C  CG    . PRO B 1 147 ? 51.701 -8.341  16.460  1.00 68.37  ? 65  PRO B CG    1 
ATOM   2204 C  CD    . PRO B 1 147 ? 51.142 -9.131  15.269  1.00 69.94  ? 65  PRO B CD    1 
ATOM   2205 N  N     . VAL B 1 148 ? 54.288 -8.853  13.321  1.00 48.37  ? 66  VAL B N     1 
ATOM   2206 C  CA    . VAL B 1 148 ? 55.419 -9.124  12.447  1.00 49.60  ? 66  VAL B CA    1 
ATOM   2207 C  C     . VAL B 1 148 ? 55.175 -8.549  11.050  1.00 48.30  ? 66  VAL B C     1 
ATOM   2208 O  O     . VAL B 1 148 ? 56.088 -8.020  10.435  1.00 47.64  ? 66  VAL B O     1 
ATOM   2209 C  CB    . VAL B 1 148 ? 55.736 -10.629 12.376  1.00 52.40  ? 66  VAL B CB    1 
ATOM   2210 C  CG1   . VAL B 1 148 ? 56.629 -10.974 11.193  1.00 53.04  ? 66  VAL B CG1   1 
ATOM   2211 C  CG2   . VAL B 1 148 ? 56.404 -11.123 13.651  1.00 56.04  ? 66  VAL B CG2   1 
ATOM   2212 N  N     . LEU B 1 149 ? 53.952 -8.668  10.532  1.00 48.45  ? 67  LEU B N     1 
ATOM   2213 C  CA    . LEU B 1 149 ? 53.671 -8.184  9.198   1.00 48.66  ? 67  LEU B CA    1 
ATOM   2214 C  C     . LEU B 1 149 ? 53.542 -6.654  9.175   1.00 50.65  ? 67  LEU B C     1 
ATOM   2215 O  O     . LEU B 1 149 ? 53.864 -6.038  8.166   1.00 47.45  ? 67  LEU B O     1 
ATOM   2216 C  CB    . LEU B 1 149 ? 52.436 -8.904  8.669   1.00 47.02  ? 67  LEU B CB    1 
ATOM   2217 C  CG    . LEU B 1 149 ? 52.645 -10.352 8.205   1.00 53.38  ? 67  LEU B CG    1 
ATOM   2218 C  CD1   . LEU B 1 149 ? 51.318 -11.105 8.134   1.00 53.38  ? 67  LEU B CD1   1 
ATOM   2219 C  CD2   . LEU B 1 149 ? 53.325 -10.434 6.853   1.00 50.92  ? 67  LEU B CD2   1 
ATOM   2220 N  N     . HIS B 1 150 ? 53.029 -6.051  10.236  1.00 51.88  ? 68  HIS B N     1 
ATOM   2221 C  CA    . HIS B 1 150 ? 52.928 -4.572  10.264  1.00 55.89  ? 68  HIS B CA    1 
ATOM   2222 C  C     . HIS B 1 150 ? 54.347 -4.003  10.275  1.00 51.37  ? 68  HIS B C     1 
ATOM   2223 O  O     . HIS B 1 150 ? 54.577 -2.961  9.649   1.00 46.64  ? 68  HIS B O     1 
ATOM   2224 C  CB    . HIS B 1 150 ? 52.053 -4.148  11.446  1.00 52.55  ? 68  HIS B CB    1 
ATOM   2225 C  CG    . HIS B 1 150 ? 50.597 -4.343  11.226  1.00 52.63  ? 68  HIS B CG    1 
ATOM   2226 N  ND1   . HIS B 1 150 ? 49.654 -3.664  11.961  1.00 66.82  ? 68  HIS B ND1   1 
ATOM   2227 C  CD2   . HIS B 1 150 ? 49.921 -5.117  10.378  1.00 55.40  ? 68  HIS B CD2   1 
ATOM   2228 C  CE1   . HIS B 1 150 ? 48.450 -4.024  11.558  1.00 59.49  ? 68  HIS B CE1   1 
ATOM   2229 N  NE2   . HIS B 1 150 ? 48.589 -4.906  10.597  1.00 53.59  ? 68  HIS B NE2   1 
ATOM   2230 N  N     . LEU B 1 151 ? 55.272 -4.707  10.912  1.00 45.21  ? 69  LEU B N     1 
ATOM   2231 C  CA    . LEU B 1 151 ? 56.639 -4.281  11.056  1.00 47.80  ? 69  LEU B CA    1 
ATOM   2232 C  C     . LEU B 1 151 ? 57.375 -4.449  9.734   1.00 49.99  ? 69  LEU B C     1 
ATOM   2233 O  O     . LEU B 1 151 ? 58.150 -3.587  9.353   1.00 48.66  ? 69  LEU B O     1 
ATOM   2234 C  CB    . LEU B 1 151 ? 57.262 -5.097  12.187  1.00 51.24  ? 69  LEU B CB    1 
ATOM   2235 C  CG    . LEU B 1 151 ? 58.730 -4.796  12.510  1.00 64.66  ? 69  LEU B CG    1 
ATOM   2236 C  CD1   . LEU B 1 151 ? 58.944 -3.336  12.948  1.00 56.45  ? 69  LEU B CD1   1 
ATOM   2237 C  CD2   . LEU B 1 151 ? 59.241 -5.774  13.571  1.00 68.47  ? 69  LEU B CD2   1 
ATOM   2238 N  N     . ILE B 1 152 ? 57.134 -5.558  9.032   1.00 54.52  ? 70  ILE B N     1 
ATOM   2239 C  CA    . ILE B 1 152 ? 57.703 -5.754  7.705   1.00 47.65  ? 70  ILE B CA    1 
ATOM   2240 C  C     . ILE B 1 152 ? 57.344 -4.530  6.862   1.00 48.58  ? 70  ILE B C     1 
ATOM   2241 O  O     . ILE B 1 152 ? 58.181 -3.979  6.148   1.00 47.56  ? 70  ILE B O     1 
ATOM   2242 C  CB    . ILE B 1 152 ? 57.239 -7.100  7.098   1.00 45.00  ? 70  ILE B CB    1 
ATOM   2243 C  CG1   . ILE B 1 152 ? 57.888 -8.261  7.857   1.00 49.37  ? 70  ILE B CG1   1 
ATOM   2244 C  CG2   . ILE B 1 152 ? 57.522 -7.208  5.594   1.00 41.91  ? 70  ILE B CG2   1 
ATOM   2245 C  CD1   . ILE B 1 152 ? 57.250 -9.623  7.642   1.00 51.93  ? 70  ILE B CD1   1 
ATOM   2246 N  N     . GLY B 1 153 ? 56.106 -4.050  6.999   1.00 52.23  ? 71  GLY B N     1 
ATOM   2247 C  CA    . GLY B 1 153 ? 55.653 -2.933  6.182   1.00 50.42  ? 71  GLY B CA    1 
ATOM   2248 C  C     . GLY B 1 153 ? 56.393 -1.649  6.532   1.00 54.27  ? 71  GLY B C     1 
ATOM   2249 O  O     . GLY B 1 153 ? 56.723 -0.892  5.631   1.00 51.91  ? 71  GLY B O     1 
ATOM   2250 N  N     . GLU B 1 154 ? 56.611 -1.429  7.848   1.00 54.09  ? 72  GLU B N     1 
ATOM   2251 C  CA    . GLU B 1 154 ? 57.181 -0.206  8.382   1.00 46.34  ? 72  GLU B CA    1 
ATOM   2252 C  C     . GLU B 1 154 ? 58.610 -0.113  7.852   1.00 45.54  ? 72  GLU B C     1 
ATOM   2253 O  O     . GLU B 1 154 ? 59.068 0.921   7.360   1.00 48.94  ? 72  GLU B O     1 
ATOM   2254 C  CB    . GLU B 1 154 ? 57.263 -0.159  9.920   1.00 53.54  ? 72  GLU B CB    1 
ATOM   2255 C  CG    . GLU B 1 154 ? 55.978 0.122   10.693  1.00 57.16  ? 72  GLU B CG    1 
ATOM   2256 C  CD    . GLU B 1 154 ? 55.141 1.256   10.112  1.00 82.87  ? 72  GLU B CD    1 
ATOM   2257 O  OE1   . GLU B 1 154 ? 55.705 2.337   9.814   1.00 92.63  ? 72  GLU B OE1   1 
ATOM   2258 O  OE2   . GLU B 1 154 ? 53.914 1.065   9.951   1.00 85.55  ? 72  GLU B OE2   1 
ATOM   2259 N  N     . ARG B 1 155 ? 59.314 -1.229  7.977   1.00 45.87  ? 73  ARG B N     1 
ATOM   2260 C  CA    . ARG B 1 155 ? 60.722 -1.274  7.664   1.00 49.26  ? 73  ARG B CA    1 
ATOM   2261 C  C     . ARG B 1 155 ? 60.883 -1.132  6.154   1.00 53.43  ? 73  ARG B C     1 
ATOM   2262 O  O     . ARG B 1 155 ? 61.816 -0.478  5.698   1.00 53.62  ? 73  ARG B O     1 
ATOM   2263 C  CB    . ARG B 1 155 ? 61.306 -2.583  8.199   1.00 50.48  ? 73  ARG B CB    1 
ATOM   2264 C  CG    . ARG B 1 155 ? 61.378 -2.748  9.710   1.00 47.52  ? 73  ARG B CG    1 
ATOM   2265 C  CD    . ARG B 1 155 ? 62.412 -3.812  9.939   1.00 60.15  ? 73  ARG B CD    1 
ATOM   2266 N  NE    . ARG B 1 155 ? 62.406 -4.369  11.290  1.00 74.36  ? 73  ARG B NE    1 
ATOM   2267 C  CZ    . ARG B 1 155 ? 63.402 -4.220  12.119  1.00 81.08  ? 73  ARG B CZ    1 
ATOM   2268 N  NH1   . ARG B 1 155 ? 64.349 -3.336  11.839  1.00 94.60  ? 73  ARG B NH1   1 
ATOM   2269 N  NH2   . ARG B 1 155 ? 63.416 -4.926  13.228  1.00 76.15  ? 73  ARG B NH2   1 
ATOM   2270 N  N     . TRP B 1 156 ? 59.967 -1.742  5.391   1.00 47.83  ? 74  TRP B N     1 
ATOM   2271 C  CA    . TRP B 1 156 ? 60.003 -1.579  3.951   1.00 50.85  ? 74  TRP B CA    1 
ATOM   2272 C  C     . TRP B 1 156 ? 59.938 -0.096  3.630   1.00 47.89  ? 74  TRP B C     1 
ATOM   2273 O  O     . TRP B 1 156 ? 60.662 0.405   2.770   1.00 41.38  ? 74  TRP B O     1 
ATOM   2274 C  CB    . TRP B 1 156 ? 58.851 -2.297  3.224   1.00 51.66  ? 74  TRP B CB    1 
ATOM   2275 C  CG    . TRP B 1 156 ? 58.799 -1.851  1.789   1.00 41.69  ? 74  TRP B CG    1 
ATOM   2276 C  CD1   . TRP B 1 156 ? 59.672 -2.224  0.817   1.00 38.83  ? 74  TRP B CD1   1 
ATOM   2277 C  CD2   . TRP B 1 156 ? 57.931 -0.864  1.193   1.00 40.27  ? 74  TRP B CD2   1 
ATOM   2278 N  NE1   . TRP B 1 156 ? 59.395 -1.559  -0.349  1.00 40.16  ? 74  TRP B NE1   1 
ATOM   2279 C  CE2   . TRP B 1 156 ? 58.345 -0.712  -0.151  1.00 36.37  ? 74  TRP B CE2   1 
ATOM   2280 C  CE3   . TRP B 1 156 ? 56.843 -0.109  1.649   1.00 39.78  ? 74  TRP B CE3   1 
ATOM   2281 C  CZ2   . TRP B 1 156 ? 57.704 0.138   -1.048  1.00 38.58  ? 74  TRP B CZ2   1 
ATOM   2282 C  CZ3   . TRP B 1 156 ? 56.216 0.748   0.763   1.00 40.69  ? 74  TRP B CZ3   1 
ATOM   2283 C  CH2   . TRP B 1 156 ? 56.653 0.889   -0.561  1.00 36.64  ? 74  TRP B CH2   1 
ATOM   2284 N  N     . ARG B 1 157 ? 59.022 0.587   4.316   1.00 48.47  ? 75  ARG B N     1 
ATOM   2285 C  CA    . ARG B 1 157 ? 58.800 2.001   4.063   1.00 53.32  ? 75  ARG B CA    1 
ATOM   2286 C  C     . ARG B 1 157 ? 60.071 2.823   4.333   1.00 49.62  ? 75  ARG B C     1 
ATOM   2287 O  O     . ARG B 1 157 ? 60.425 3.681   3.532   1.00 49.13  ? 75  ARG B O     1 
ATOM   2288 C  CB    . ARG B 1 157 ? 57.583 2.481   4.858   1.00 50.75  ? 75  ARG B CB    1 
ATOM   2289 C  CG    . ARG B 1 157 ? 56.969 3.697   4.193   1.00 52.85  ? 75  ARG B CG    1 
ATOM   2290 C  CD    . ARG B 1 157 ? 55.792 4.293   4.944   1.00 56.06  ? 75  ARG B CD    1 
ATOM   2291 N  NE    . ARG B 1 157 ? 55.282 5.369   4.089   1.00 61.95  ? 75  ARG B NE    1 
ATOM   2292 C  CZ    . ARG B 1 157 ? 54.648 5.204   2.933   1.00 63.14  ? 75  ARG B CZ    1 
ATOM   2293 N  NH1   . ARG B 1 157 ? 54.091 4.044   2.603   1.00 60.09  ? 75  ARG B NH1   1 
ATOM   2294 N  NH2   . ARG B 1 157 ? 54.529 6.243   2.131   1.00 72.78  ? 75  ARG B NH2   1 
ATOM   2295 N  N     . ARG B 1 158 ? 60.778 2.512   5.427   1.00 47.64  ? 76  ARG B N     1 
ATOM   2296 C  CA    . ARG B 1 158 ? 61.979 3.227   5.843   1.00 48.28  ? 76  ARG B CA    1 
ATOM   2297 C  C     . ARG B 1 158 ? 63.241 2.780   5.094   1.00 47.78  ? 76  ARG B C     1 
ATOM   2298 O  O     . ARG B 1 158 ? 64.322 3.249   5.423   1.00 51.86  ? 76  ARG B O     1 
ATOM   2299 C  CB    . ARG B 1 158 ? 62.190 3.018   7.357   1.00 51.96  ? 76  ARG B CB    1 
ATOM   2300 C  CG    . ARG B 1 158 ? 61.045 3.578   8.199   1.00 59.21  ? 76  ARG B CG    1 
ATOM   2301 C  CD    . ARG B 1 158 ? 61.495 3.945   9.604   1.00 69.06  ? 76  ARG B CD    1 
ATOM   2302 N  NE    . ARG B 1 158 ? 61.752 2.740   10.395  1.00 78.60  ? 76  ARG B NE    1 
ATOM   2303 C  CZ    . ARG B 1 158 ? 60.790 2.042   11.005  1.00 83.47  ? 76  ARG B CZ    1 
ATOM   2304 N  NH1   . ARG B 1 158 ? 59.547 2.497   10.973  1.00 84.48  ? 76  ARG B NH1   1 
ATOM   2305 N  NH2   . ARG B 1 158 ? 61.068 0.917   11.664  1.00 72.70  ? 76  ARG B NH2   1 
ATOM   2306 N  N     . GLY B 1 159 ? 63.135 1.848   4.135   1.00 47.85  ? 77  GLY B N     1 
ATOM   2307 C  CA    . GLY B 1 159 ? 64.282 1.299   3.427   1.00 41.70  ? 77  GLY B CA    1 
ATOM   2308 C  C     . GLY B 1 159 ? 65.125 0.321   4.258   1.00 45.87  ? 77  GLY B C     1 
ATOM   2309 O  O     . GLY B 1 159 ? 66.216 -0.030  3.828   1.00 45.95  ? 77  GLY B O     1 
ATOM   2310 N  N     . GLU B 1 160 ? 64.639 -0.164  5.412   1.00 49.33  ? 78  GLU B N     1 
ATOM   2311 C  CA    . GLU B 1 160 ? 65.395 -1.117  6.232   1.00 53.78  ? 78  GLU B CA    1 
ATOM   2312 C  C     . GLU B 1 160 ? 65.181 -2.577  5.780   1.00 55.02  ? 78  GLU B C     1 
ATOM   2313 O  O     . GLU B 1 160 ? 65.855 -3.483  6.256   1.00 54.08  ? 78  GLU B O     1 
ATOM   2314 C  CB    . GLU B 1 160 ? 64.970 -1.012  7.697   1.00 54.73  ? 78  GLU B CB    1 
ATOM   2315 C  CG    . GLU B 1 160 ? 64.786 0.431   8.144   1.00 63.24  ? 78  GLU B CG    1 
ATOM   2316 C  CD    . GLU B 1 160 ? 64.558 0.646   9.618   1.00 66.12  ? 78  GLU B CD    1 
ATOM   2317 O  OE1   . GLU B 1 160 ? 63.470 0.422   10.180  1.00 70.62  ? 78  GLU B OE1   1 
ATOM   2318 O  OE2   . GLU B 1 160 ? 65.553 1.049   10.212  1.00 82.67  ? 78  GLU B OE2   1 
ATOM   2319 N  N     . LEU B 1 161 ? 64.241 -2.797  4.851   1.00 48.47  ? 79  LEU B N     1 
ATOM   2320 C  CA    . LEU B 1 161 ? 63.803 -4.096  4.377   1.00 45.12  ? 79  LEU B CA    1 
ATOM   2321 C  C     . LEU B 1 161 ? 63.382 -3.945  2.920   1.00 41.80  ? 79  LEU B C     1 
ATOM   2322 O  O     . LEU B 1 161 ? 62.786 -2.929  2.543   1.00 46.42  ? 79  LEU B O     1 
ATOM   2323 C  CB    . LEU B 1 161 ? 62.639 -4.569  5.266   1.00 52.48  ? 79  LEU B CB    1 
ATOM   2324 C  CG    . LEU B 1 161 ? 61.992 -5.918  4.911   1.00 56.27  ? 79  LEU B CG    1 
ATOM   2325 C  CD1   . LEU B 1 161 ? 61.517 -6.692  6.131   1.00 57.02  ? 79  LEU B CD1   1 
ATOM   2326 C  CD2   . LEU B 1 161 ? 60.817 -5.764  3.966   1.00 58.16  ? 79  LEU B CD2   1 
ATOM   2327 N  N     . ASN B 1 162 ? 63.638 -4.971  2.106   1.00 41.93  ? 80  ASN B N     1 
ATOM   2328 C  CA    . ASN B 1 162 ? 63.328 -4.858  0.692   1.00 43.85  ? 80  ASN B CA    1 
ATOM   2329 C  C     . ASN B 1 162 ? 62.150 -5.747  0.327   1.00 45.88  ? 80  ASN B C     1 
ATOM   2330 O  O     . ASN B 1 162 ? 61.746 -6.642  1.079   1.00 37.38  ? 80  ASN B O     1 
ATOM   2331 C  CB    . ASN B 1 162 ? 64.537 -5.147  -0.181  1.00 51.82  ? 80  ASN B CB    1 
ATOM   2332 C  CG    . ASN B 1 162 ? 65.660 -4.153  0.051   1.00 56.05  ? 80  ASN B CG    1 
ATOM   2333 O  OD1   . ASN B 1 162 ? 66.780 -4.575  0.340   1.00 55.60  ? 80  ASN B OD1   1 
ATOM   2334 N  ND2   . ASN B 1 162 ? 65.399 -2.856  -0.041  1.00 49.85  ? 80  ASN B ND2   1 
ATOM   2335 N  N     . ILE B 1 163 ? 61.627 -5.467  -0.871  1.00 45.12  ? 81  ILE B N     1 
ATOM   2336 C  CA    . ILE B 1 163 ? 60.487 -6.177  -1.415  1.00 44.40  ? 81  ILE B CA    1 
ATOM   2337 C  C     . ILE B 1 163 ? 60.689 -7.687  -1.324  1.00 46.08  ? 81  ILE B C     1 
ATOM   2338 O  O     . ILE B 1 163 ? 59.781 -8.389  -0.882  1.00 44.75  ? 81  ILE B O     1 
ATOM   2339 C  CB    . ILE B 1 163 ? 60.234 -5.740  -2.862  1.00 45.40  ? 81  ILE B CB    1 
ATOM   2340 C  CG1   . ILE B 1 163 ? 59.612 -4.327  -2.922  1.00 45.28  ? 81  ILE B CG1   1 
ATOM   2341 C  CG2   . ILE B 1 163 ? 59.364 -6.783  -3.573  1.00 46.67  ? 81  ILE B CG2   1 
ATOM   2342 C  CD1   . ILE B 1 163 ? 59.637 -3.703  -4.307  1.00 43.28  ? 81  ILE B CD1   1 
ATOM   2343 N  N     . TRP B 1 164 ? 61.858 -8.175  -1.773  1.00 46.53  ? 82  TRP B N     1 
ATOM   2344 C  CA    . TRP B 1 164 ? 62.088 -9.606  -1.860  1.00 48.33  ? 82  TRP B CA    1 
ATOM   2345 C  C     . TRP B 1 164 ? 61.793 -10.258 -0.514  1.00 44.91  ? 82  TRP B C     1 
ATOM   2346 O  O     . TRP B 1 164 ? 61.199 -11.331 -0.492  1.00 41.44  ? 82  TRP B O     1 
ATOM   2347 C  CB    . TRP B 1 164 ? 63.488 -9.971  -2.389  1.00 48.26  ? 82  TRP B CB    1 
ATOM   2348 C  CG    . TRP B 1 164 ? 64.652 -9.663  -1.482  1.00 47.58  ? 82  TRP B CG    1 
ATOM   2349 C  CD1   . TRP B 1 164 ? 65.401 -8.534  -1.530  1.00 56.70  ? 82  TRP B CD1   1 
ATOM   2350 C  CD2   . TRP B 1 164 ? 65.236 -10.470 -0.437  1.00 48.72  ? 82  TRP B CD2   1 
ATOM   2351 N  NE1   . TRP B 1 164 ? 66.396 -8.571  -0.598  1.00 52.67  ? 82  TRP B NE1   1 
ATOM   2352 C  CE2   . TRP B 1 164 ? 66.318 -9.737  0.095   1.00 46.76  ? 82  TRP B CE2   1 
ATOM   2353 C  CE3   . TRP B 1 164 ? 64.954 -11.726 0.117   1.00 52.35  ? 82  TRP B CE3   1 
ATOM   2354 C  CZ2   . TRP B 1 164 ? 67.114 -10.202 1.138   1.00 46.51  ? 82  TRP B CZ2   1 
ATOM   2355 C  CZ3   . TRP B 1 164 ? 65.731 -12.180 1.166   1.00 51.73  ? 82  TRP B CZ3   1 
ATOM   2356 C  CH2   . TRP B 1 164 ? 66.810 -11.436 1.658   1.00 44.30  ? 82  TRP B CH2   1 
ATOM   2357 N  N     . GLU B 1 165 ? 62.142 -9.574  0.589   1.00 47.07  ? 83  GLU B N     1 
ATOM   2358 C  CA    . GLU B 1 165 ? 61.969 -10.126 1.930   1.00 47.40  ? 83  GLU B CA    1 
ATOM   2359 C  C     . GLU B 1 165 ? 60.495 -10.168 2.343   1.00 43.71  ? 83  GLU B C     1 
ATOM   2360 O  O     . GLU B 1 165 ? 60.065 -11.066 3.049   1.00 41.25  ? 83  GLU B O     1 
ATOM   2361 C  CB    . GLU B 1 165 ? 62.741 -9.324  2.970   1.00 50.50  ? 83  GLU B CB    1 
ATOM   2362 C  CG    . GLU B 1 165 ? 64.184 -9.047  2.567   1.00 58.22  ? 83  GLU B CG    1 
ATOM   2363 C  CD    . GLU B 1 165 ? 64.931 -8.186  3.569   1.00 56.13  ? 83  GLU B CD    1 
ATOM   2364 O  OE1   . GLU B 1 165 ? 65.391 -8.723  4.593   1.00 50.74  ? 83  GLU B OE1   1 
ATOM   2365 O  OE2   . GLU B 1 165 ? 65.016 -6.976  3.311   1.00 55.18  ? 83  GLU B OE2   1 
ATOM   2366 N  N     . GLU B 1 166 ? 59.719 -9.167  1.938   1.00 46.65  ? 84  GLU B N     1 
ATOM   2367 C  CA    . GLU B 1 166 ? 58.286 -9.169  2.199   1.00 47.66  ? 84  GLU B CA    1 
ATOM   2368 C  C     . GLU B 1 166 ? 57.611 -10.289 1.395   1.00 48.63  ? 84  GLU B C     1 
ATOM   2369 O  O     . GLU B 1 166 ? 56.843 -11.070 1.947   1.00 47.63  ? 84  GLU B O     1 
ATOM   2370 C  CB    . GLU B 1 166 ? 57.725 -7.777  1.897   1.00 45.80  ? 84  GLU B CB    1 
ATOM   2371 C  CG    . GLU B 1 166 ? 56.203 -7.749  1.805   1.00 45.64  ? 84  GLU B CG    1 
ATOM   2372 C  CD    . GLU B 1 166 ? 55.656 -8.319  0.508   1.00 45.15  ? 84  GLU B CD    1 
ATOM   2373 O  OE1   . GLU B 1 166 ? 56.094 -7.855  -0.568  1.00 39.07  ? 84  GLU B OE1   1 
ATOM   2374 O  OE2   . GLU B 1 166 ? 54.787 -9.232  0.578   1.00 48.87  ? 84  GLU B OE2   1 
ATOM   2375 N  N     . HIS B 1 167 ? 57.866 -10.340 0.082   1.00 44.24  ? 85  HIS B N     1 
ATOM   2376 C  CA    . HIS B 1 167 ? 57.281 -11.354 -0.770  1.00 41.93  ? 85  HIS B CA    1 
ATOM   2377 C  C     . HIS B 1 167 ? 57.432 -12.739 -0.124  1.00 44.84  ? 85  HIS B C     1 
ATOM   2378 O  O     . HIS B 1 167 ? 56.474 -13.519 -0.085  1.00 43.73  ? 85  HIS B O     1 
ATOM   2379 C  CB    . HIS B 1 167 ? 57.925 -11.266 -2.157  1.00 40.60  ? 85  HIS B CB    1 
ATOM   2380 C  CG    . HIS B 1 167 ? 57.243 -10.336 -3.085  1.00 39.07  ? 85  HIS B CG    1 
ATOM   2381 N  ND1   . HIS B 1 167 ? 56.661 -9.159  -2.664  1.00 33.49  ? 85  HIS B ND1   1 
ATOM   2382 C  CD2   . HIS B 1 167 ? 56.999 -10.446 -4.421  1.00 37.95  ? 85  HIS B CD2   1 
ATOM   2383 C  CE1   . HIS B 1 167 ? 56.097 -8.571  -3.718  1.00 36.64  ? 85  HIS B CE1   1 
ATOM   2384 N  NE2   . HIS B 1 167 ? 56.296 -9.326  -4.805  1.00 34.86  ? 85  HIS B NE2   1 
ATOM   2385 N  N     . LEU B 1 168 ? 58.644 -13.032 0.376   1.00 41.69  ? 86  LEU B N     1 
ATOM   2386 C  CA    . LEU B 1 168 ? 58.938 -14.319 0.976   1.00 42.76  ? 86  LEU B CA    1 
ATOM   2387 C  C     . LEU B 1 168 ? 58.076 -14.500 2.219   1.00 44.72  ? 86  LEU B C     1 
ATOM   2388 O  O     . LEU B 1 168 ? 57.480 -15.565 2.405   1.00 45.12  ? 86  LEU B O     1 
ATOM   2389 C  CB    . LEU B 1 168 ? 60.412 -14.513 1.328   1.00 42.92  ? 86  LEU B CB    1 
ATOM   2390 C  CG    . LEU B 1 168 ? 61.358 -14.750 0.145   1.00 52.04  ? 86  LEU B CG    1 
ATOM   2391 C  CD1   . LEU B 1 168 ? 62.790 -14.998 0.634   1.00 54.03  ? 86  LEU B CD1   1 
ATOM   2392 C  CD2   . LEU B 1 168 ? 60.916 -15.873 -0.787  1.00 47.98  ? 86  LEU B CD2   1 
ATOM   2393 N  N     . ALA B 1 169 ? 58.040 -13.472 3.077   1.00 41.87  ? 87  ALA B N     1 
ATOM   2394 C  CA    . ALA B 1 169 ? 57.282 -13.558 4.316   1.00 46.77  ? 87  ALA B CA    1 
ATOM   2395 C  C     . ALA B 1 169 ? 55.793 -13.792 4.035   1.00 45.11  ? 87  ALA B C     1 
ATOM   2396 O  O     . ALA B 1 169 ? 55.125 -14.497 4.788   1.00 45.54  ? 87  ALA B O     1 
ATOM   2397 C  CB    . ALA B 1 169 ? 57.514 -12.323 5.165   1.00 46.80  ? 87  ALA B CB    1 
ATOM   2398 N  N     . SER B 1 170 ? 55.280 -13.207 2.945   1.00 45.95  ? 88  SER B N     1 
ATOM   2399 C  CA    . SER B 1 170 ? 53.869 -13.296 2.600   1.00 43.94  ? 88  SER B CA    1 
ATOM   2400 C  C     . SER B 1 170 ? 53.505 -14.702 2.127   1.00 45.13  ? 88  SER B C     1 
ATOM   2401 O  O     . SER B 1 170 ? 52.421 -15.163 2.435   1.00 44.70  ? 88  SER B O     1 
ATOM   2402 C  CB    . SER B 1 170 ? 53.503 -12.277 1.562   1.00 47.66  ? 88  SER B CB    1 
ATOM   2403 O  OG    . SER B 1 170 ? 53.481 -10.959 2.108   1.00 50.53  ? 88  SER B OG    1 
ATOM   2404 N  N     . GLN B 1 171 ? 54.396 -15.364 1.373   1.00 41.42  ? 89  GLN B N     1 
ATOM   2405 C  CA    . GLN B 1 171 ? 54.167 -16.732 0.945   1.00 43.08  ? 89  GLN B CA    1 
ATOM   2406 C  C     . GLN B 1 171 ? 54.313 -17.695 2.119   1.00 42.80  ? 89  GLN B C     1 
ATOM   2407 O  O     . GLN B 1 171 ? 53.475 -18.568 2.300   1.00 44.25  ? 89  GLN B O     1 
ATOM   2408 C  CB    . GLN B 1 171 ? 55.166 -17.129 -0.129  1.00 41.29  ? 89  GLN B CB    1 
ATOM   2409 C  CG    . GLN B 1 171 ? 55.042 -16.297 -1.395  1.00 44.20  ? 89  GLN B CG    1 
ATOM   2410 C  CD    . GLN B 1 171 ? 53.645 -16.318 -1.983  1.00 44.42  ? 89  GLN B CD    1 
ATOM   2411 O  OE1   . GLN B 1 171 ? 53.042 -17.371 -2.148  1.00 46.26  ? 89  GLN B OE1   1 
ATOM   2412 N  NE2   . GLN B 1 171 ? 53.122 -15.155 -2.333  1.00 48.50  ? 89  GLN B NE2   1 
ATOM   2413 N  N     . VAL B 1 172 ? 55.384 -17.530 2.901   1.00 43.19  ? 90  VAL B N     1 
ATOM   2414 C  CA    . VAL B 1 172 ? 55.564 -18.275 4.136   1.00 43.67  ? 90  VAL B CA    1 
ATOM   2415 C  C     . VAL B 1 172 ? 54.282 -18.167 4.954   1.00 44.51  ? 90  VAL B C     1 
ATOM   2416 O  O     . VAL B 1 172 ? 53.766 -19.178 5.395   1.00 50.77  ? 90  VAL B O     1 
ATOM   2417 C  CB    . VAL B 1 172 ? 56.780 -17.833 4.972   1.00 43.91  ? 90  VAL B CB    1 
ATOM   2418 C  CG1   . VAL B 1 172 ? 56.700 -18.369 6.405   1.00 45.59  ? 90  VAL B CG1   1 
ATOM   2419 C  CG2   . VAL B 1 172 ? 58.092 -18.251 4.310   1.00 42.47  ? 90  VAL B CG2   1 
ATOM   2420 N  N     . THR B 1 173 ? 53.723 -16.965 5.112   1.00 47.90  ? 91  THR B N     1 
ATOM   2421 C  CA    . THR B 1 173 ? 52.587 -16.809 6.018   1.00 49.54  ? 91  THR B CA    1 
ATOM   2422 C  C     . THR B 1 173 ? 51.348 -17.510 5.454   1.00 47.77  ? 91  THR B C     1 
ATOM   2423 O  O     . THR B 1 173 ? 50.682 -18.244 6.175   1.00 48.47  ? 91  THR B O     1 
ATOM   2424 C  CB    . THR B 1 173 ? 52.326 -15.335 6.345   1.00 49.49  ? 91  THR B CB    1 
ATOM   2425 O  OG1   . THR B 1 173 ? 53.517 -14.837 6.948   1.00 44.59  ? 91  THR B OG1   1 
ATOM   2426 C  CG2   . THR B 1 173 ? 51.192 -15.142 7.341   1.00 48.81  ? 91  THR B CG2   1 
ATOM   2427 N  N     . LEU B 1 174 ? 51.060 -17.310 4.159   1.00 48.79  ? 92  LEU B N     1 
ATOM   2428 C  CA    . LEU B 1 174 ? 49.914 -17.941 3.511   1.00 47.59  ? 92  LEU B CA    1 
ATOM   2429 C  C     . LEU B 1 174 ? 49.995 -19.463 3.678   1.00 42.87  ? 92  LEU B C     1 
ATOM   2430 O  O     . LEU B 1 174 ? 49.005 -20.115 3.948   1.00 39.10  ? 92  LEU B O     1 
ATOM   2431 C  CB    . LEU B 1 174 ? 49.814 -17.544 2.030   1.00 43.13  ? 92  LEU B CB    1 
ATOM   2432 C  CG    . LEU B 1 174 ? 49.537 -16.059 1.731   1.00 47.81  ? 92  LEU B CG    1 
ATOM   2433 C  CD1   . LEU B 1 174 ? 49.734 -15.685 0.250   1.00 43.72  ? 92  LEU B CD1   1 
ATOM   2434 C  CD2   . LEU B 1 174 ? 48.165 -15.606 2.204   1.00 45.68  ? 92  LEU B CD2   1 
ATOM   2435 N  N     . ALA B 1 175 ? 51.187 -20.017 3.496   1.00 40.99  ? 93  ALA B N     1 
ATOM   2436 C  CA    . ALA B 1 175 ? 51.364 -21.448 3.482   1.00 40.27  ? 93  ALA B CA    1 
ATOM   2437 C  C     . ALA B 1 175 ? 51.318 -21.971 4.914   1.00 45.45  ? 93  ALA B C     1 
ATOM   2438 O  O     . ALA B 1 175 ? 50.699 -22.998 5.201   1.00 50.21  ? 93  ALA B O     1 
ATOM   2439 C  CB    . ALA B 1 175 ? 52.671 -21.756 2.808   1.00 37.16  ? 93  ALA B CB    1 
ATOM   2440 N  N     . ALA B 1 176 ? 51.970 -21.232 5.809   1.00 45.13  ? 94  ALA B N     1 
ATOM   2441 C  CA    . ALA B 1 176 ? 52.129 -21.651 7.187   1.00 47.66  ? 94  ALA B CA    1 
ATOM   2442 C  C     . ALA B 1 176 ? 50.793 -21.650 7.926   1.00 49.77  ? 94  ALA B C     1 
ATOM   2443 O  O     . ALA B 1 176 ? 50.517 -22.502 8.770   1.00 59.46  ? 94  ALA B O     1 
ATOM   2444 C  CB    . ALA B 1 176 ? 53.130 -20.757 7.886   1.00 45.50  ? 94  ALA B CB    1 
ATOM   2445 N  N     . THR B 1 177 ? 49.966 -20.664 7.631   1.00 48.02  ? 95  THR B N     1 
ATOM   2446 C  CA    . THR B 1 177 ? 48.731 -20.519 8.361   1.00 45.55  ? 95  THR B CA    1 
ATOM   2447 C  C     . THR B 1 177 ? 47.760 -21.608 7.878   1.00 52.13  ? 95  THR B C     1 
ATOM   2448 O  O     . THR B 1 177 ? 47.050 -22.214 8.678   1.00 49.71  ? 95  THR B O     1 
ATOM   2449 C  CB    . THR B 1 177 ? 48.322 -19.062 8.151   1.00 45.23  ? 95  THR B CB    1 
ATOM   2450 O  OG1   . THR B 1 177 ? 47.548 -18.676 9.264   1.00 55.58  ? 95  THR B OG1   1 
ATOM   2451 C  CG2   . THR B 1 177 ? 47.523 -18.799 6.893   1.00 49.19  ? 95  THR B CG2   1 
ATOM   2452 N  N     . GLU B 1 178 ? 47.807 -21.945 6.576   1.00 52.00  ? 96  GLU B N     1 
ATOM   2453 C  CA    . GLU B 1 178 ? 46.986 -23.007 6.015   1.00 52.02  ? 96  GLU B CA    1 
ATOM   2454 C  C     . GLU B 1 178 ? 47.372 -24.371 6.609   1.00 49.52  ? 96  GLU B C     1 
ATOM   2455 O  O     . GLU B 1 178 ? 46.506 -25.169 6.959   1.00 49.46  ? 96  GLU B O     1 
ATOM   2456 C  CB    . GLU B 1 178 ? 47.067 -22.996 4.488   1.00 48.71  ? 96  GLU B CB    1 
ATOM   2457 C  CG    . GLU B 1 178 ? 46.361 -24.180 3.817   1.00 61.04  ? 96  GLU B CG    1 
ATOM   2458 C  CD    . GLU B 1 178 ? 44.893 -24.435 4.205   1.00 73.14  ? 96  GLU B CD    1 
ATOM   2459 O  OE1   . GLU B 1 178 ? 44.020 -23.560 3.982   1.00 69.57  ? 96  GLU B OE1   1 
ATOM   2460 O  OE2   . GLU B 1 178 ? 44.592 -25.531 4.736   1.00 89.53  ? 96  GLU B OE2   1 
ATOM   2461 N  N     . HIS B 1 179 ? 48.675 -24.627 6.697   1.00 45.44  ? 97  HIS B N     1 
ATOM   2462 C  CA    . HIS B 1 179 ? 49.244 -25.872 7.194   1.00 48.26  ? 97  HIS B CA    1 
ATOM   2463 C  C     . HIS B 1 179 ? 48.800 -26.137 8.635   1.00 50.79  ? 97  HIS B C     1 
ATOM   2464 O  O     . HIS B 1 179 ? 48.436 -27.246 9.003   1.00 57.39  ? 97  HIS B O     1 
ATOM   2465 C  CB    . HIS B 1 179 ? 50.772 -25.758 7.079   1.00 48.91  ? 97  HIS B CB    1 
ATOM   2466 C  CG    . HIS B 1 179 ? 51.578 -26.993 7.360   1.00 53.60  ? 97  HIS B CG    1 
ATOM   2467 N  ND1   . HIS B 1 179 ? 52.752 -27.229 6.659   1.00 53.81  ? 97  HIS B ND1   1 
ATOM   2468 C  CD2   . HIS B 1 179 ? 51.433 -28.020 8.229   1.00 46.89  ? 97  HIS B CD2   1 
ATOM   2469 C  CE1   . HIS B 1 179 ? 53.289 -28.357 7.098   1.00 55.20  ? 97  HIS B CE1   1 
ATOM   2470 N  NE2   . HIS B 1 179 ? 52.507 -28.852 8.049   1.00 51.74  ? 97  HIS B NE2   1 
ATOM   2471 N  N     . LEU B 1 180 ? 48.865 -25.114 9.472   1.00 52.50  ? 98  LEU B N     1 
ATOM   2472 C  CA    . LEU B 1 180 ? 48.461 -25.247 10.852  1.00 53.10  ? 98  LEU B CA    1 
ATOM   2473 C  C     . LEU B 1 180 ? 46.959 -25.499 10.941  1.00 49.18  ? 98  LEU B C     1 
ATOM   2474 O  O     . LEU B 1 180 ? 46.514 -26.295 11.763  1.00 48.48  ? 98  LEU B O     1 
ATOM   2475 C  CB    . LEU B 1 180 ? 48.814 -23.960 11.593  1.00 59.32  ? 98  LEU B CB    1 
ATOM   2476 C  CG    . LEU B 1 180 ? 48.415 -23.974 13.073  1.00 64.28  ? 98  LEU B CG    1 
ATOM   2477 C  CD1   . LEU B 1 180 ? 49.256 -25.032 13.804  1.00 57.79  ? 98  LEU B CD1   1 
ATOM   2478 C  CD2   . LEU B 1 180 ? 48.509 -22.609 13.715  1.00 63.83  ? 98  LEU B CD2   1 
ATOM   2479 N  N     . HIS B 1 181 ? 46.184 -24.762 10.133  1.00 49.02  ? 99  HIS B N     1 
ATOM   2480 C  CA    . HIS B 1 181 ? 44.728 -24.839 10.125  1.00 48.07  ? 99  HIS B CA    1 
ATOM   2481 C  C     . HIS B 1 181 ? 44.244 -26.281 9.958   1.00 57.98  ? 99  HIS B C     1 
ATOM   2482 O  O     . HIS B 1 181 ? 43.422 -26.750 10.752  1.00 54.48  ? 99  HIS B O     1 
ATOM   2483 C  CB    . HIS B 1 181 ? 44.190 -24.026 8.952   1.00 45.59  ? 99  HIS B CB    1 
ATOM   2484 C  CG    . HIS B 1 181 ? 42.708 -23.908 8.912   1.00 45.06  ? 99  HIS B CG    1 
ATOM   2485 N  ND1   . HIS B 1 181 ? 41.977 -23.379 9.952   1.00 47.03  ? 99  HIS B ND1   1 
ATOM   2486 C  CD2   . HIS B 1 181 ? 41.840 -24.097 7.908   1.00 42.71  ? 99  HIS B CD2   1 
ATOM   2487 C  CE1   . HIS B 1 181 ? 40.696 -23.317 9.589   1.00 46.96  ? 99  HIS B CE1   1 
ATOM   2488 N  NE2   . HIS B 1 181 ? 40.584 -23.745 8.354   1.00 41.89  ? 99  HIS B NE2   1 
ATOM   2489 N  N     . ARG B 1 182 ? 44.813 -26.987 8.956   1.00 58.73  ? 100 ARG B N     1 
ATOM   2490 C  CA    . ARG B 1 182 ? 44.441 -28.359 8.646   1.00 60.55  ? 100 ARG B CA    1 
ATOM   2491 C  C     . ARG B 1 182 ? 44.753 -29.307 9.806   1.00 57.38  ? 100 ARG B C     1 
ATOM   2492 O  O     . ARG B 1 182 ? 44.217 -30.410 9.850   1.00 60.02  ? 100 ARG B O     1 
ATOM   2493 C  CB    . ARG B 1 182 ? 45.085 -28.817 7.334   1.00 67.68  ? 100 ARG B CB    1 
ATOM   2494 C  CG    . ARG B 1 182 ? 46.592 -29.021 7.360   1.00 81.81  ? 100 ARG B CG    1 
ATOM   2495 C  CD    . ARG B 1 182 ? 47.090 -29.961 6.256   1.00 85.02  ? 100 ARG B CD    1 
ATOM   2496 N  NE    . ARG B 1 182 ? 48.554 -30.021 6.153   1.00 76.23  ? 100 ARG B NE    1 
ATOM   2497 C  CZ    . ARG B 1 182 ? 49.275 -29.366 5.237   1.00 91.05  ? 100 ARG B CZ    1 
ATOM   2498 N  NH1   . ARG B 1 182 ? 48.723 -28.411 4.494   1.00 83.54  ? 100 ARG B NH1   1 
ATOM   2499 N  NH2   . ARG B 1 182 ? 50.563 -29.641 5.094   1.00 90.84  ? 100 ARG B NH2   1 
ATOM   2500 N  N     . GLN B 1 183 ? 45.578 -28.883 10.774  1.00 53.33  ? 101 GLN B N     1 
ATOM   2501 C  CA    . GLN B 1 183 ? 45.897 -29.732 11.913  1.00 47.17  ? 101 GLN B CA    1 
ATOM   2502 C  C     . GLN B 1 183 ? 45.105 -29.376 13.168  1.00 52.07  ? 101 GLN B C     1 
ATOM   2503 O  O     . GLN B 1 183 ? 45.474 -29.854 14.243  1.00 56.26  ? 101 GLN B O     1 
ATOM   2504 C  CB    . GLN B 1 183 ? 47.381 -29.680 12.261  1.00 49.92  ? 101 GLN B CB    1 
ATOM   2505 C  CG    . GLN B 1 183 ? 48.281 -30.054 11.086  1.00 55.56  ? 101 GLN B CG    1 
ATOM   2506 C  CD    . GLN B 1 183 ? 49.711 -30.299 11.494  1.00 62.39  ? 101 GLN B CD    1 
ATOM   2507 O  OE1   . GLN B 1 183 ? 50.149 -29.941 12.602  1.00 66.26  ? 101 GLN B OE1   1 
ATOM   2508 N  NE2   . GLN B 1 183 ? 50.428 -30.938 10.581  1.00 59.82  ? 101 GLN B NE2   1 
ATOM   2509 N  N     . LEU B 1 184 ? 44.011 -28.607 13.021  1.00 50.76  ? 102 LEU B N     1 
ATOM   2510 C  CA    . LEU B 1 184 ? 43.289 -28.057 14.162  1.00 56.33  ? 102 LEU B CA    1 
ATOM   2511 C  C     . LEU B 1 184 ? 41.924 -28.718 14.307  1.00 52.47  ? 102 LEU B C     1 
ATOM   2512 O  O     . LEU B 1 184 ? 41.214 -28.887 13.320  1.00 53.09  ? 102 LEU B O     1 
ATOM   2513 C  CB    . LEU B 1 184 ? 43.078 -26.548 14.005  1.00 67.75  ? 102 LEU B CB    1 
ATOM   2514 C  CG    . LEU B 1 184 ? 44.301 -25.630 14.156  1.00 66.39  ? 102 LEU B CG    1 
ATOM   2515 C  CD1   . LEU B 1 184 ? 43.815 -24.172 14.015  1.00 63.21  ? 102 LEU B CD1   1 
ATOM   2516 C  CD2   . LEU B 1 184 ? 45.079 -25.834 15.459  1.00 55.62  ? 102 LEU B CD2   1 
ATOM   2517 N  N     . PRO B 1 185 ? 41.492 -29.032 15.547  1.00 56.06  ? 103 PRO B N     1 
ATOM   2518 C  CA    . PRO B 1 185 ? 40.082 -29.321 15.826  1.00 56.97  ? 103 PRO B CA    1 
ATOM   2519 C  C     . PRO B 1 185 ? 39.154 -28.233 15.301  1.00 61.25  ? 103 PRO B C     1 
ATOM   2520 O  O     . PRO B 1 185 ? 39.471 -27.054 15.409  1.00 72.03  ? 103 PRO B O     1 
ATOM   2521 C  CB    . PRO B 1 185 ? 39.996 -29.426 17.346  1.00 62.08  ? 103 PRO B CB    1 
ATOM   2522 C  CG    . PRO B 1 185 ? 41.437 -29.687 17.818  1.00 67.18  ? 103 PRO B CG    1 
ATOM   2523 C  CD    . PRO B 1 185 ? 42.354 -29.154 16.735  1.00 63.26  ? 103 PRO B CD    1 
ATOM   2524 N  N     . ARG B 1 186 ? 38.008 -28.649 14.752  1.00 64.47  ? 104 ARG B N     1 
ATOM   2525 C  CA    . ARG B 1 186 ? 36.967 -27.745 14.297  1.00 70.28  ? 104 ARG B CA    1 
ATOM   2526 C  C     . ARG B 1 186 ? 35.652 -28.090 14.986  1.00 71.37  ? 104 ARG B C     1 
ATOM   2527 O  O     . ARG B 1 186 ? 35.354 -29.258 15.198  1.00 76.15  ? 104 ARG B O     1 
ATOM   2528 C  CB    . ARG B 1 186 ? 36.769 -27.905 12.789  1.00 73.99  ? 104 ARG B CB    1 
ATOM   2529 C  CG    . ARG B 1 186 ? 38.117 -27.882 12.094  1.00 86.77  ? 104 ARG B CG    1 
ATOM   2530 C  CD    . ARG B 1 186 ? 38.031 -27.565 10.620  1.00 96.67  ? 104 ARG B CD    1 
ATOM   2531 N  NE    . ARG B 1 186 ? 39.406 -27.428 10.125  1.00 100.22 ? 104 ARG B NE    1 
ATOM   2532 C  CZ    . ARG B 1 186 ? 39.779 -27.033 8.906   1.00 95.61  ? 104 ARG B CZ    1 
ATOM   2533 N  NH1   . ARG B 1 186 ? 38.884 -26.684 7.991   1.00 81.96  ? 104 ARG B NH1   1 
ATOM   2534 N  NH2   . ARG B 1 186 ? 41.070 -26.995 8.612   1.00 94.68  ? 104 ARG B NH2   1 
ATOM   2535 N  N     . ALA B 1 187 ? 34.860 -27.065 15.300  1.00 70.48  ? 105 ALA B N     1 
ATOM   2536 C  CA    . ALA B 1 187 ? 33.455 -27.245 15.630  1.00 70.47  ? 105 ALA B CA    1 
ATOM   2537 C  C     . ALA B 1 187 ? 32.752 -28.030 14.520  1.00 72.96  ? 105 ALA B C     1 
ATOM   2538 O  O     . ALA B 1 187 ? 33.222 -28.091 13.387  1.00 67.85  ? 105 ALA B O     1 
ATOM   2539 C  CB    . ALA B 1 187 ? 32.784 -25.898 15.858  1.00 64.18  ? 105 ALA B CB    1 
ATOM   2540 N  N     . PRO B 1 188 ? 31.607 -28.684 14.808  1.00 78.62  ? 106 PRO B N     1 
ATOM   2541 C  CA    . PRO B 1 188 ? 30.842 -29.348 13.751  1.00 73.57  ? 106 PRO B CA    1 
ATOM   2542 C  C     . PRO B 1 188 ? 30.173 -28.308 12.849  1.00 64.25  ? 106 PRO B C     1 
ATOM   2543 O  O     . PRO B 1 188 ? 29.909 -27.186 13.296  1.00 63.30  ? 106 PRO B O     1 
ATOM   2544 C  CB    . PRO B 1 188 ? 29.832 -30.234 14.531  1.00 79.74  ? 106 PRO B CB    1 
ATOM   2545 C  CG    . PRO B 1 188 ? 30.218 -30.121 16.011  1.00 77.55  ? 106 PRO B CG    1 
ATOM   2546 C  CD    . PRO B 1 188 ? 31.016 -28.845 16.151  1.00 78.72  ? 106 PRO B CD    1 
ATOM   2547 N  N     . PHE B 1 189 ? 29.878 -28.690 11.592  1.00 52.56  ? 107 PHE B N     1 
ATOM   2548 C  CA    . PHE B 1 189 ? 29.227 -27.775 10.663  1.00 55.60  ? 107 PHE B CA    1 
ATOM   2549 C  C     . PHE B 1 189 ? 28.064 -27.103 11.377  1.00 58.29  ? 107 PHE B C     1 
ATOM   2550 O  O     . PHE B 1 189 ? 27.454 -27.711 12.235  1.00 72.04  ? 107 PHE B O     1 
ATOM   2551 C  CB    . PHE B 1 189 ? 28.732 -28.495 9.412   1.00 57.12  ? 107 PHE B CB    1 
ATOM   2552 C  CG    . PHE B 1 189 ? 28.167 -27.600 8.313   1.00 69.98  ? 107 PHE B CG    1 
ATOM   2553 C  CD1   . PHE B 1 189 ? 28.708 -26.344 8.036   1.00 72.05  ? 107 PHE B CD1   1 
ATOM   2554 C  CD2   . PHE B 1 189 ? 27.111 -28.037 7.513   1.00 75.67  ? 107 PHE B CD2   1 
ATOM   2555 C  CE1   . PHE B 1 189 ? 28.203 -25.557 7.000   1.00 71.82  ? 107 PHE B CE1   1 
ATOM   2556 C  CE2   . PHE B 1 189 ? 26.608 -27.244 6.483   1.00 71.56  ? 107 PHE B CE2   1 
ATOM   2557 C  CZ    . PHE B 1 189 ? 27.153 -26.007 6.227   1.00 68.88  ? 107 PHE B CZ    1 
ATOM   2558 N  N     . ASN B 1 190 ? 27.776 -25.836 11.083  1.00 70.73  ? 108 ASN B N     1 
ATOM   2559 C  CA    . ASN B 1 190 ? 26.749 -25.115 11.829  1.00 68.49  ? 108 ASN B CA    1 
ATOM   2560 C  C     . ASN B 1 190 ? 25.636 -24.684 10.884  1.00 68.93  ? 108 ASN B C     1 
ATOM   2561 O  O     . ASN B 1 190 ? 24.792 -23.867 11.257  1.00 71.60  ? 108 ASN B O     1 
ATOM   2562 C  CB    . ASN B 1 190 ? 27.323 -23.936 12.615  1.00 72.97  ? 108 ASN B CB    1 
ATOM   2563 C  CG    . ASN B 1 190 ? 27.883 -22.823 11.749  1.00 78.87  ? 108 ASN B CG    1 
ATOM   2564 O  OD1   . ASN B 1 190 ? 27.670 -22.775 10.528  1.00 69.28  ? 108 ASN B OD1   1 
ATOM   2565 N  ND2   . ASN B 1 190 ? 28.602 -21.899 12.369  1.00 77.82  ? 108 ASN B ND2   1 
ATOM   2566 N  N     . GLY B 1 191 ? 25.696 -25.187 9.642   1.00 73.91  ? 109 GLY B N     1 
ATOM   2567 C  CA    . GLY B 1 191 ? 24.716 -24.883 8.608   1.00 73.10  ? 109 GLY B CA    1 
ATOM   2568 C  C     . GLY B 1 191 ? 24.873 -23.506 7.960   1.00 74.17  ? 109 GLY B C     1 
ATOM   2569 O  O     . GLY B 1 191 ? 24.154 -23.204 7.013   1.00 72.44  ? 109 GLY B O     1 
ATOM   2570 N  N     . ARG B 1 192 ? 25.806 -22.671 8.439   1.00 81.06  ? 110 ARG B N     1 
ATOM   2571 C  CA    . ARG B 1 192 ? 25.875 -21.284 7.997   1.00 80.41  ? 110 ARG B CA    1 
ATOM   2572 C  C     . ARG B 1 192 ? 27.012 -21.101 6.983   1.00 71.28  ? 110 ARG B C     1 
ATOM   2573 O  O     . ARG B 1 192 ? 28.056 -21.735 7.078   1.00 71.52  ? 110 ARG B O     1 
ATOM   2574 C  CB    . ARG B 1 192 ? 25.976 -20.355 9.214   1.00 79.11  ? 110 ARG B CB    1 
ATOM   2575 C  CG    . ARG B 1 192 ? 24.842 -20.512 10.217  1.00 84.45  ? 110 ARG B CG    1 
ATOM   2576 C  CD    . ARG B 1 192 ? 24.770 -19.322 11.169  1.00 86.89  ? 110 ARG B CD    1 
ATOM   2577 N  NE    . ARG B 1 192 ? 23.823 -19.441 12.289  1.00 79.14  ? 110 ARG B NE    1 
ATOM   2578 C  CZ    . ARG B 1 192 ? 24.176 -19.813 13.526  1.00 86.26  ? 110 ARG B CZ    1 
ATOM   2579 N  NH1   . ARG B 1 192 ? 25.283 -20.511 13.732  1.00 92.74  ? 110 ARG B NH1   1 
ATOM   2580 N  NH2   . ARG B 1 192 ? 23.401 -19.542 14.562  1.00 91.39  ? 110 ARG B NH2   1 
ATOM   2581 N  N     . LEU B 1 193 ? 26.788 -20.213 6.010   1.00 72.19  ? 111 LEU B N     1 
ATOM   2582 C  CA    . LEU B 1 193 ? 27.723 -19.948 4.929   1.00 72.00  ? 111 LEU B CA    1 
ATOM   2583 C  C     . LEU B 1 193 ? 28.199 -18.497 5.000   1.00 66.89  ? 111 LEU B C     1 
ATOM   2584 O  O     . LEU B 1 193 ? 27.377 -17.581 4.998   1.00 62.00  ? 111 LEU B O     1 
ATOM   2585 C  CB    . LEU B 1 193 ? 27.049 -20.233 3.589   1.00 63.86  ? 111 LEU B CB    1 
ATOM   2586 C  CG    . LEU B 1 193 ? 27.877 -19.959 2.330   1.00 67.20  ? 111 LEU B CG    1 
ATOM   2587 C  CD1   . LEU B 1 193 ? 29.065 -20.871 2.291   1.00 69.86  ? 111 LEU B CD1   1 
ATOM   2588 C  CD2   . LEU B 1 193 ? 27.044 -20.111 1.064   1.00 68.53  ? 111 LEU B CD2   1 
ATOM   2589 N  N     . ALA B 1 194 ? 29.533 -18.330 5.014   1.00 62.73  ? 112 ALA B N     1 
ATOM   2590 C  CA    . ALA B 1 194 ? 30.204 -17.038 4.919   1.00 61.71  ? 112 ALA B CA    1 
ATOM   2591 C  C     . ALA B 1 194 ? 30.831 -16.861 3.539   1.00 60.80  ? 112 ALA B C     1 
ATOM   2592 O  O     . ALA B 1 194 ? 31.543 -17.759 3.062   1.00 61.25  ? 112 ALA B O     1 
ATOM   2593 C  CB    . ALA B 1 194 ? 31.270 -16.940 5.973   1.00 56.85  ? 112 ALA B CB    1 
ATOM   2594 N  N     . LEU B 1 195 ? 30.562 -15.687 2.937   1.00 58.83  ? 113 LEU B N     1 
ATOM   2595 C  CA    . LEU B 1 195 ? 31.149 -15.258 1.667   1.00 62.78  ? 113 LEU B CA    1 
ATOM   2596 C  C     . LEU B 1 195 ? 32.237 -14.206 1.908   1.00 58.42  ? 113 LEU B C     1 
ATOM   2597 O  O     . LEU B 1 195 ? 31.926 -13.141 2.448   1.00 58.81  ? 113 LEU B O     1 
ATOM   2598 C  CB    . LEU B 1 195 ? 30.043 -14.670 0.795   1.00 57.41  ? 113 LEU B CB    1 
ATOM   2599 C  CG    . LEU B 1 195 ? 30.496 -14.220 -0.591  1.00 60.60  ? 113 LEU B CG    1 
ATOM   2600 C  CD1   . LEU B 1 195 ? 30.903 -15.408 -1.464  1.00 61.93  ? 113 LEU B CD1   1 
ATOM   2601 C  CD2   . LEU B 1 195 ? 29.410 -13.417 -1.227  1.00 58.45  ? 113 LEU B CD2   1 
ATOM   2602 N  N     . CYS B 1 196 ? 33.481 -14.479 1.471   1.00 52.58  ? 114 CYS B N     1 
ATOM   2603 C  CA    . CYS B 1 196 ? 34.633 -13.666 1.870   1.00 54.19  ? 114 CYS B CA    1 
ATOM   2604 C  C     . CYS B 1 196 ? 35.440 -13.144 0.675   1.00 52.11  ? 114 CYS B C     1 
ATOM   2605 O  O     . CYS B 1 196 ? 35.614 -13.816 -0.356  1.00 43.48  ? 114 CYS B O     1 
ATOM   2606 C  CB    . CYS B 1 196 ? 35.498 -14.432 2.854   1.00 54.29  ? 114 CYS B CB    1 
ATOM   2607 S  SG    . CYS B 1 196 ? 34.574 -14.959 4.324   1.00 57.84  ? 114 CYS B SG    1 
ATOM   2608 N  N     . GLY B 1 197 ? 35.908 -11.893 0.815   1.00 52.65  ? 115 GLY B N     1 
ATOM   2609 C  CA    . GLY B 1 197 ? 36.643 -11.225 -0.250  1.00 49.90  ? 115 GLY B CA    1 
ATOM   2610 C  C     . GLY B 1 197 ? 37.353 -9.951  0.212   1.00 51.32  ? 115 GLY B C     1 
ATOM   2611 O  O     . GLY B 1 197 ? 37.172 -9.471  1.333   1.00 44.17  ? 115 GLY B O     1 
ATOM   2612 N  N     . CYS B 1 198 ? 38.186 -9.405  -0.682  1.00 48.35  ? 116 CYS B N     1 
ATOM   2613 C  CA    . CYS B 1 198 ? 38.724 -8.066  -0.516  1.00 39.84  ? 116 CYS B CA    1 
ATOM   2614 C  C     . CYS B 1 198 ? 38.291 -7.239  -1.715  1.00 41.52  ? 116 CYS B C     1 
ATOM   2615 O  O     . CYS B 1 198 ? 38.021 -7.802  -2.784  1.00 50.85  ? 116 CYS B O     1 
ATOM   2616 C  CB    . CYS B 1 198 ? 40.238 -8.102  -0.457  1.00 40.40  ? 116 CYS B CB    1 
ATOM   2617 S  SG    . CYS B 1 198 ? 40.914 -9.396  0.611   1.00 48.02  ? 116 CYS B SG    1 
ATOM   2618 N  N     . PRO B 1 199 ? 38.194 -5.894  -1.615  1.00 44.25  ? 117 PRO B N     1 
ATOM   2619 C  CA    . PRO B 1 199 ? 37.676 -5.095  -2.740  1.00 46.18  ? 117 PRO B CA    1 
ATOM   2620 C  C     . PRO B 1 199 ? 38.506 -5.121  -4.027  1.00 42.98  ? 117 PRO B C     1 
ATOM   2621 O  O     . PRO B 1 199 ? 39.565 -5.720  -4.076  1.00 43.73  ? 117 PRO B O     1 
ATOM   2622 C  CB    . PRO B 1 199 ? 37.617 -3.699  -2.133  1.00 45.02  ? 117 PRO B CB    1 
ATOM   2623 C  CG    . PRO B 1 199 ? 37.503 -3.972  -0.635  1.00 47.40  ? 117 PRO B CG    1 
ATOM   2624 C  CD    . PRO B 1 199 ? 38.514 -5.087  -0.426  1.00 43.95  ? 117 PRO B CD    1 
ATOM   2625 N  N     . GLU B 1 200 ? 38.019 -4.454  -5.067  1.00 49.46  ? 118 GLU B N     1 
ATOM   2626 C  CA    . GLU B 1 200 ? 38.682 -4.467  -6.358  1.00 50.06  ? 118 GLU B CA    1 
ATOM   2627 C  C     . GLU B 1 200 ? 39.956 -3.636  -6.246  1.00 49.80  ? 118 GLU B C     1 
ATOM   2628 O  O     . GLU B 1 200 ? 39.942 -2.616  -5.574  1.00 56.82  ? 118 GLU B O     1 
ATOM   2629 C  CB    . GLU B 1 200 ? 37.760 -3.877  -7.421  1.00 46.35  ? 118 GLU B CB    1 
ATOM   2630 C  CG    . GLU B 1 200 ? 38.226 -4.100  -8.853  1.00 45.66  ? 118 GLU B CG    1 
ATOM   2631 C  CD    . GLU B 1 200 ? 37.252 -3.501  -9.836  1.00 50.12  ? 118 GLU B CD    1 
ATOM   2632 O  OE1   . GLU B 1 200 ? 36.159 -3.107  -9.377  1.00 52.15  ? 118 GLU B OE1   1 
ATOM   2633 O  OE2   . GLU B 1 200 ? 37.580 -3.400  -11.033 1.00 46.39  ? 118 GLU B OE2   1 
ATOM   2634 N  N     . GLY B 1 201 ? 41.051 -4.116  -6.858  1.00 45.84  ? 119 GLY B N     1 
ATOM   2635 C  CA    . GLY B 1 201 ? 42.340 -3.442  -6.843  1.00 43.60  ? 119 GLY B CA    1 
ATOM   2636 C  C     . GLY B 1 201 ? 43.101 -3.575  -5.523  1.00 43.84  ? 119 GLY B C     1 
ATOM   2637 O  O     . GLY B 1 201 ? 44.137 -2.959  -5.372  1.00 51.42  ? 119 GLY B O     1 
ATOM   2638 N  N     . ASP B 1 202 ? 42.619 -4.355  -4.551  1.00 48.88  ? 120 ASP B N     1 
ATOM   2639 C  CA    . ASP B 1 202 ? 43.361 -4.592  -3.313  1.00 49.58  ? 120 ASP B CA    1 
ATOM   2640 C  C     . ASP B 1 202 ? 43.936 -6.016  -3.311  1.00 53.30  ? 120 ASP B C     1 
ATOM   2641 O  O     . ASP B 1 202 ? 43.162 -6.970  -3.422  1.00 49.82  ? 120 ASP B O     1 
ATOM   2642 C  CB    . ASP B 1 202 ? 42.447 -4.373  -2.119  1.00 45.46  ? 120 ASP B CB    1 
ATOM   2643 C  CG    . ASP B 1 202 ? 43.100 -4.344  -0.750  1.00 47.60  ? 120 ASP B CG    1 
ATOM   2644 O  OD1   . ASP B 1 202 ? 44.278 -4.737  -0.632  1.00 50.93  ? 120 ASP B OD1   1 
ATOM   2645 O  OD2   . ASP B 1 202 ? 42.412 -3.946  0.197   1.00 53.01  ? 120 ASP B OD2   1 
ATOM   2646 N  N     . LEU B 1 203 ? 45.274 -6.163  -3.152  1.00 48.90  ? 121 LEU B N     1 
ATOM   2647 C  CA    . LEU B 1 203 ? 45.952 -7.451  -3.290  1.00 41.53  ? 121 LEU B CA    1 
ATOM   2648 C  C     . LEU B 1 203 ? 46.324 -8.048  -1.935  1.00 41.25  ? 121 LEU B C     1 
ATOM   2649 O  O     . LEU B 1 203 ? 46.837 -9.175  -1.870  1.00 39.59  ? 121 LEU B O     1 
ATOM   2650 C  CB    . LEU B 1 203 ? 47.186 -7.299  -4.166  1.00 39.49  ? 121 LEU B CB    1 
ATOM   2651 C  CG    . LEU B 1 203 ? 46.927 -6.673  -5.539  1.00 44.79  ? 121 LEU B CG    1 
ATOM   2652 C  CD1   . LEU B 1 203 ? 48.254 -6.313  -6.201  1.00 42.33  ? 121 LEU B CD1   1 
ATOM   2653 C  CD2   . LEU B 1 203 ? 46.085 -7.571  -6.455  1.00 44.68  ? 121 LEU B CD2   1 
ATOM   2654 N  N     . HIS B 1 204 ? 46.055 -7.300  -0.858  1.00 42.64  ? 122 HIS B N     1 
ATOM   2655 C  CA    . HIS B 1 204 ? 46.393 -7.734  0.493   1.00 44.10  ? 122 HIS B CA    1 
ATOM   2656 C  C     . HIS B 1 204 ? 45.338 -8.753  0.941   1.00 43.40  ? 122 HIS B C     1 
ATOM   2657 O  O     . HIS B 1 204 ? 44.165 -8.441  1.101   1.00 41.83  ? 122 HIS B O     1 
ATOM   2658 C  CB    . HIS B 1 204 ? 46.493 -6.531  1.444   1.00 43.88  ? 122 HIS B CB    1 
ATOM   2659 C  CG    . HIS B 1 204 ? 47.522 -5.503  1.069   1.00 46.39  ? 122 HIS B CG    1 
ATOM   2660 N  ND1   . HIS B 1 204 ? 47.302 -4.529  0.114   1.00 43.87  ? 122 HIS B ND1   1 
ATOM   2661 C  CD2   . HIS B 1 204 ? 48.783 -5.298  1.513   1.00 44.80  ? 122 HIS B CD2   1 
ATOM   2662 C  CE1   . HIS B 1 204 ? 48.396 -3.782  -0.011  1.00 42.90  ? 122 HIS B CE1   1 
ATOM   2663 N  NE2   . HIS B 1 204 ? 49.301 -4.212  0.846   1.00 42.42  ? 122 HIS B NE2   1 
ATOM   2664 N  N     . GLU B 1 205 ? 45.761 -9.995  1.157   1.00 51.03  ? 123 GLU B N     1 
ATOM   2665 C  CA    . GLU B 1 205 ? 44.806 -11.078 1.309   1.00 48.62  ? 123 GLU B CA    1 
ATOM   2666 C  C     . GLU B 1 205 ? 45.129 -11.953 2.505   1.00 42.54  ? 123 GLU B C     1 
ATOM   2667 O  O     . GLU B 1 205 ? 44.385 -12.899 2.730   1.00 49.86  ? 123 GLU B O     1 
ATOM   2668 C  CB    . GLU B 1 205 ? 44.617 -11.947 0.060   1.00 47.11  ? 123 GLU B CB    1 
ATOM   2669 C  CG    . GLU B 1 205 ? 45.728 -12.961 -0.208  1.00 49.88  ? 123 GLU B CG    1 
ATOM   2670 C  CD    . GLU B 1 205 ? 45.736 -13.532 -1.621  1.00 48.10  ? 123 GLU B CD    1 
ATOM   2671 O  OE1   . GLU B 1 205 ? 44.774 -14.255 -2.011  1.00 53.42  ? 123 GLU B OE1   1 
ATOM   2672 O  OE2   . GLU B 1 205 ? 46.741 -13.250 -2.326  1.00 46.68  ? 123 GLU B OE2   1 
ATOM   2673 N  N     . ILE B 1 206 ? 46.133 -11.606 3.315   1.00 44.39  ? 124 ILE B N     1 
ATOM   2674 C  CA    . ILE B 1 206 ? 46.492 -12.494 4.417   1.00 48.71  ? 124 ILE B CA    1 
ATOM   2675 C  C     . ILE B 1 206 ? 45.436 -12.431 5.514   1.00 55.96  ? 124 ILE B C     1 
ATOM   2676 O  O     . ILE B 1 206 ? 45.108 -13.453 6.119   1.00 59.13  ? 124 ILE B O     1 
ATOM   2677 C  CB    . ILE B 1 206 ? 47.882 -12.198 4.986   1.00 46.54  ? 124 ILE B CB    1 
ATOM   2678 C  CG1   . ILE B 1 206 ? 48.980 -12.722 4.062   1.00 49.48  ? 124 ILE B CG1   1 
ATOM   2679 C  CG2   . ILE B 1 206 ? 48.001 -12.778 6.395   1.00 48.02  ? 124 ILE B CG2   1 
ATOM   2680 C  CD1   . ILE B 1 206 ? 50.374 -12.195 4.371   1.00 47.89  ? 124 ILE B CD1   1 
ATOM   2681 N  N     . ALA B 1 207 ? 44.946 -11.224 5.810   1.00 56.81  ? 125 ALA B N     1 
ATOM   2682 C  CA    . ALA B 1 207 ? 43.960 -11.081 6.869   1.00 55.42  ? 125 ALA B CA    1 
ATOM   2683 C  C     . ALA B 1 207 ? 42.715 -11.897 6.523   1.00 52.03  ? 125 ALA B C     1 
ATOM   2684 O  O     . ALA B 1 207 ? 42.162 -12.593 7.380   1.00 44.70  ? 125 ALA B O     1 
ATOM   2685 C  CB    . ALA B 1 207 ? 43.645 -9.626  7.090   1.00 57.31  ? 125 ALA B CB    1 
ATOM   2686 N  N     . LEU B 1 208 ? 42.316 -11.833 5.246   1.00 46.04  ? 126 LEU B N     1 
ATOM   2687 C  CA    . LEU B 1 208 ? 41.152 -12.555 4.783   1.00 49.92  ? 126 LEU B CA    1 
ATOM   2688 C  C     . LEU B 1 208 ? 41.344 -14.042 5.084   1.00 52.40  ? 126 LEU B C     1 
ATOM   2689 O  O     . LEU B 1 208 ? 40.412 -14.717 5.496   1.00 51.77  ? 126 LEU B O     1 
ATOM   2690 C  CB    . LEU B 1 208 ? 40.961 -12.314 3.289   1.00 52.79  ? 126 LEU B CB    1 
ATOM   2691 C  CG    . LEU B 1 208 ? 39.676 -12.891 2.682   1.00 54.73  ? 126 LEU B CG    1 
ATOM   2692 C  CD1   . LEU B 1 208 ? 38.458 -12.073 3.099   1.00 57.65  ? 126 LEU B CD1   1 
ATOM   2693 C  CD2   . LEU B 1 208 ? 39.746 -12.943 1.162   1.00 56.48  ? 126 LEU B CD2   1 
ATOM   2694 N  N     . HIS B 1 209 ? 42.557 -14.557 4.876   1.00 46.71  ? 127 HIS B N     1 
ATOM   2695 C  CA    . HIS B 1 209 ? 42.816 -15.967 5.130   1.00 51.25  ? 127 HIS B CA    1 
ATOM   2696 C  C     . HIS B 1 209 ? 42.642 -16.235 6.618   1.00 50.15  ? 127 HIS B C     1 
ATOM   2697 O  O     . HIS B 1 209 ? 42.129 -17.280 6.982   1.00 53.51  ? 127 HIS B O     1 
ATOM   2698 C  CB    . HIS B 1 209 ? 44.192 -16.429 4.608   1.00 48.83  ? 127 HIS B CB    1 
ATOM   2699 C  CG    . HIS B 1 209 ? 44.182 -16.721 3.144   1.00 49.86  ? 127 HIS B CG    1 
ATOM   2700 N  ND1   . HIS B 1 209 ? 43.970 -15.747 2.191   1.00 52.53  ? 127 HIS B ND1   1 
ATOM   2701 C  CD2   . HIS B 1 209 ? 44.252 -17.873 2.490   1.00 55.36  ? 127 HIS B CD2   1 
ATOM   2702 C  CE1   . HIS B 1 209 ? 43.941 -16.306 0.989   1.00 64.40  ? 127 HIS B CE1   1 
ATOM   2703 N  NE2   . HIS B 1 209 ? 44.109 -17.605 1.155   1.00 59.18  ? 127 HIS B NE2   1 
ATOM   2704 N  N     . LEU B 1 210 ? 43.125 -15.299 7.440   1.00 51.62  ? 128 LEU B N     1 
ATOM   2705 C  CA    . LEU B 1 210 ? 43.145 -15.436 8.884   1.00 50.36  ? 128 LEU B CA    1 
ATOM   2706 C  C     . LEU B 1 210 ? 41.713 -15.533 9.405   1.00 53.19  ? 128 LEU B C     1 
ATOM   2707 O  O     . LEU B 1 210 ? 41.442 -16.267 10.347  1.00 47.91  ? 128 LEU B O     1 
ATOM   2708 C  CB    . LEU B 1 210 ? 43.874 -14.220 9.464   1.00 50.77  ? 128 LEU B CB    1 
ATOM   2709 C  CG    . LEU B 1 210 ? 45.315 -14.451 9.934   1.00 54.62  ? 128 LEU B CG    1 
ATOM   2710 C  CD1   . LEU B 1 210 ? 46.209 -15.217 8.955   1.00 47.75  ? 128 LEU B CD1   1 
ATOM   2711 C  CD2   . LEU B 1 210 ? 45.894 -13.091 10.284  1.00 48.91  ? 128 LEU B CD2   1 
ATOM   2712 N  N     . VAL B 1 211 ? 40.813 -14.769 8.782   1.00 48.69  ? 129 VAL B N     1 
ATOM   2713 C  CA    . VAL B 1 211 ? 39.421 -14.705 9.182   1.00 52.24  ? 129 VAL B CA    1 
ATOM   2714 C  C     . VAL B 1 211 ? 38.662 -15.961 8.741   1.00 53.63  ? 129 VAL B C     1 
ATOM   2715 O  O     . VAL B 1 211 ? 37.977 -16.594 9.549   1.00 53.91  ? 129 VAL B O     1 
ATOM   2716 C  CB    . VAL B 1 211 ? 38.892 -13.416 8.523   1.00 48.14  ? 129 VAL B CB    1 
ATOM   2717 C  CG1   . VAL B 1 211 ? 37.376 -13.404 8.371   1.00 48.20  ? 129 VAL B CG1   1 
ATOM   2718 C  CG2   . VAL B 1 211 ? 39.397 -12.184 9.259   1.00 48.79  ? 129 VAL B CG2   1 
ATOM   2719 N  N     . MET B 1 212 ? 38.793 -16.294 7.446   1.00 48.26  ? 130 MET B N     1 
ATOM   2720 C  CA    . MET B 1 212 ? 38.175 -17.463 6.850   1.00 48.95  ? 130 MET B CA    1 
ATOM   2721 C  C     . MET B 1 212 ? 38.537 -18.703 7.667   1.00 48.75  ? 130 MET B C     1 
ATOM   2722 O  O     . MET B 1 212 ? 37.695 -19.539 7.969   1.00 47.93  ? 130 MET B O     1 
ATOM   2723 C  CB    . MET B 1 212 ? 38.610 -17.611 5.386   1.00 47.29  ? 130 MET B CB    1 
ATOM   2724 C  CG    . MET B 1 212 ? 38.024 -16.555 4.446   1.00 49.01  ? 130 MET B CG    1 
ATOM   2725 S  SD    . MET B 1 212 ? 38.302 -16.890 2.688   1.00 50.13  ? 130 MET B SD    1 
ATOM   2726 C  CE    . MET B 1 212 ? 40.095 -16.903 2.682   1.00 47.17  ? 130 MET B CE    1 
ATOM   2727 N  N     . GLU B 1 213 ? 39.803 -18.814 8.048   1.00 47.71  ? 131 GLU B N     1 
ATOM   2728 C  CA    . GLU B 1 213 ? 40.211 -19.921 8.889   1.00 56.83  ? 131 GLU B CA    1 
ATOM   2729 C  C     . GLU B 1 213 ? 39.370 -19.894 10.157  1.00 58.23  ? 131 GLU B C     1 
ATOM   2730 O  O     . GLU B 1 213 ? 38.785 -20.914 10.514  1.00 57.00  ? 131 GLU B O     1 
ATOM   2731 C  CB    . GLU B 1 213 ? 41.688 -19.930 9.289   1.00 56.52  ? 131 GLU B CB    1 
ATOM   2732 C  CG    . GLU B 1 213 ? 42.639 -20.090 8.110   1.00 52.49  ? 131 GLU B CG    1 
ATOM   2733 C  CD    . GLU B 1 213 ? 44.096 -19.840 8.429   1.00 57.69  ? 131 GLU B CD    1 
ATOM   2734 O  OE1   . GLU B 1 213 ? 44.482 -19.680 9.639   1.00 56.16  ? 131 GLU B OE1   1 
ATOM   2735 O  OE2   . GLU B 1 213 ? 44.833 -19.864 7.403   1.00 54.84  ? 131 GLU B OE2   1 
ATOM   2736 N  N     . VAL B 1 214 ? 39.338 -18.738 10.831  1.00 53.12  ? 132 VAL B N     1 
ATOM   2737 C  CA    . VAL B 1 214 ? 38.634 -18.638 12.102  1.00 63.81  ? 132 VAL B CA    1 
ATOM   2738 C  C     . VAL B 1 214 ? 37.187 -19.108 11.921  1.00 59.54  ? 132 VAL B C     1 
ATOM   2739 O  O     . VAL B 1 214 ? 36.691 -19.887 12.738  1.00 55.51  ? 132 VAL B O     1 
ATOM   2740 C  CB    . VAL B 1 214 ? 38.730 -17.237 12.738  1.00 66.35  ? 132 VAL B CB    1 
ATOM   2741 C  CG1   . VAL B 1 214 ? 37.599 -16.936 13.713  1.00 68.36  ? 132 VAL B CG1   1 
ATOM   2742 C  CG2   . VAL B 1 214 ? 40.075 -17.065 13.448  1.00 68.15  ? 132 VAL B CG2   1 
ATOM   2743 N  N     . LEU B 1 215 ? 36.542 -18.689 10.827  1.00 50.26  ? 133 LEU B N     1 
ATOM   2744 C  CA    . LEU B 1 215 ? 35.191 -19.140 10.530  1.00 62.19  ? 133 LEU B CA    1 
ATOM   2745 C  C     . LEU B 1 215 ? 35.080 -20.675 10.469  1.00 65.19  ? 133 LEU B C     1 
ATOM   2746 O  O     . LEU B 1 215 ? 34.196 -21.258 11.100  1.00 68.30  ? 133 LEU B O     1 
ATOM   2747 C  CB    . LEU B 1 215 ? 34.725 -18.459 9.244   1.00 59.36  ? 133 LEU B CB    1 
ATOM   2748 C  CG    . LEU B 1 215 ? 34.262 -17.013 9.423   1.00 59.85  ? 133 LEU B CG    1 
ATOM   2749 C  CD1   . LEU B 1 215 ? 34.065 -16.238 8.113   1.00 55.39  ? 133 LEU B CD1   1 
ATOM   2750 C  CD2   . LEU B 1 215 ? 32.982 -17.039 10.244  1.00 59.34  ? 133 LEU B CD2   1 
ATOM   2751 N  N     . GLU B 1 216 ? 35.965 -21.343 9.718   1.00 58.67  ? 134 GLU B N     1 
ATOM   2752 C  CA    . GLU B 1 216 ? 35.864 -22.785 9.537   1.00 59.74  ? 134 GLU B CA    1 
ATOM   2753 C  C     . GLU B 1 216 ? 36.052 -23.554 10.851  1.00 59.22  ? 134 GLU B C     1 
ATOM   2754 O  O     . GLU B 1 216 ? 35.419 -24.589 11.053  1.00 66.53  ? 134 GLU B O     1 
ATOM   2755 C  CB    . GLU B 1 216 ? 36.883 -23.238 8.495   1.00 53.53  ? 134 GLU B CB    1 
ATOM   2756 C  CG    . GLU B 1 216 ? 36.491 -22.860 7.072   1.00 51.04  ? 134 GLU B CG    1 
ATOM   2757 C  CD    . GLU B 1 216 ? 37.467 -23.444 6.069   1.00 55.60  ? 134 GLU B CD    1 
ATOM   2758 O  OE1   . GLU B 1 216 ? 38.576 -23.834 6.501   1.00 60.20  ? 134 GLU B OE1   1 
ATOM   2759 O  OE2   . GLU B 1 216 ? 37.123 -23.533 4.873   1.00 55.82  ? 134 GLU B OE2   1 
ATOM   2760 N  N     . VAL B 1 217 ? 36.928 -23.045 11.725  1.00 54.33  ? 135 VAL B N     1 
ATOM   2761 C  CA    . VAL B 1 217 ? 37.137 -23.577 13.062  1.00 60.34  ? 135 VAL B CA    1 
ATOM   2762 C  C     . VAL B 1 217 ? 35.868 -23.403 13.905  1.00 65.15  ? 135 VAL B C     1 
ATOM   2763 O  O     . VAL B 1 217 ? 35.588 -24.247 14.741  1.00 62.05  ? 135 VAL B O     1 
ATOM   2764 C  CB    . VAL B 1 217 ? 38.332 -22.915 13.777  1.00 60.42  ? 135 VAL B CB    1 
ATOM   2765 C  CG1   . VAL B 1 217 ? 38.488 -23.435 15.206  1.00 60.15  ? 135 VAL B CG1   1 
ATOM   2766 C  CG2   . VAL B 1 217 ? 39.637 -23.057 12.999  1.00 54.05  ? 135 VAL B CG2   1 
ATOM   2767 N  N     . GLU B 1 218 ? 35.110 -22.316 13.694  1.00 66.20  ? 136 GLU B N     1 
ATOM   2768 C  CA    . GLU B 1 218 ? 33.804 -22.145 14.319  1.00 65.28  ? 136 GLU B CA    1 
ATOM   2769 C  C     . GLU B 1 218 ? 32.729 -22.939 13.578  1.00 65.14  ? 136 GLU B C     1 
ATOM   2770 O  O     . GLU B 1 218 ? 31.550 -22.813 13.892  1.00 65.39  ? 136 GLU B O     1 
ATOM   2771 C  CB    . GLU B 1 218 ? 33.380 -20.675 14.341  1.00 63.08  ? 136 GLU B CB    1 
ATOM   2772 C  CG    . GLU B 1 218 ? 34.265 -19.815 15.234  1.00 67.96  ? 136 GLU B CG    1 
ATOM   2773 C  CD    . GLU B 1 218 ? 34.309 -20.265 16.685  1.00 67.57  ? 136 GLU B CD    1 
ATOM   2774 O  OE1   . GLU B 1 218 ? 33.263 -20.120 17.364  1.00 68.66  ? 136 GLU B OE1   1 
ATOM   2775 O  OE2   . GLU B 1 218 ? 35.383 -20.749 17.115  1.00 57.77  ? 136 GLU B OE2   1 
ATOM   2776 N  N     . GLY B 1 219 ? 33.125 -23.696 12.548  1.00 70.09  ? 137 GLY B N     1 
ATOM   2777 C  CA    . GLY B 1 219 ? 32.247 -24.670 11.925  1.00 63.63  ? 137 GLY B CA    1 
ATOM   2778 C  C     . GLY B 1 219 ? 31.453 -24.076 10.768  1.00 64.23  ? 137 GLY B C     1 
ATOM   2779 O  O     . GLY B 1 219 ? 30.520 -24.711 10.291  1.00 67.87  ? 137 GLY B O     1 
ATOM   2780 N  N     . TRP B 1 220 ? 31.814 -22.875 10.297  1.00 62.47  ? 138 TRP B N     1 
ATOM   2781 C  CA    . TRP B 1 220 ? 31.158 -22.317 9.117   1.00 60.44  ? 138 TRP B CA    1 
ATOM   2782 C  C     . TRP B 1 220 ? 31.744 -22.918 7.843   1.00 62.81  ? 138 TRP B C     1 
ATOM   2783 O  O     . TRP B 1 220 ? 32.918 -23.281 7.813   1.00 69.31  ? 138 TRP B O     1 
ATOM   2784 C  CB    . TRP B 1 220 ? 31.356 -20.806 9.002   1.00 58.04  ? 138 TRP B CB    1 
ATOM   2785 C  CG    . TRP B 1 220 ? 30.731 -19.956 10.065  1.00 53.76  ? 138 TRP B CG    1 
ATOM   2786 C  CD1   . TRP B 1 220 ? 31.054 -19.873 11.390  1.00 52.63  ? 138 TRP B CD1   1 
ATOM   2787 C  CD2   . TRP B 1 220 ? 29.743 -18.938 9.812   1.00 42.86  ? 138 TRP B CD2   1 
ATOM   2788 N  NE1   . TRP B 1 220 ? 30.275 -18.919 11.997  1.00 52.31  ? 138 TRP B NE1   1 
ATOM   2789 C  CE2   . TRP B 1 220 ? 29.483 -18.315 11.048  1.00 45.64  ? 138 TRP B CE2   1 
ATOM   2790 C  CE3   . TRP B 1 220 ? 29.061 -18.520 8.666   1.00 50.45  ? 138 TRP B CE3   1 
ATOM   2791 C  CZ2   . TRP B 1 220 ? 28.563 -17.282 11.164  1.00 50.85  ? 138 TRP B CZ2   1 
ATOM   2792 C  CZ3   . TRP B 1 220 ? 28.152 -17.496 8.772   1.00 47.46  ? 138 TRP B CZ3   1 
ATOM   2793 C  CH2   . TRP B 1 220 ? 27.923 -16.880 10.005  1.00 56.82  ? 138 TRP B CH2   1 
ATOM   2794 N  N     . ARG B 1 221 ? 30.929 -22.947 6.787   1.00 60.70  ? 139 ARG B N     1 
ATOM   2795 C  CA    . ARG B 1 221 ? 31.419 -23.220 5.451   1.00 70.85  ? 139 ARG B CA    1 
ATOM   2796 C  C     . ARG B 1 221 ? 31.684 -21.847 4.850   1.00 64.37  ? 139 ARG B C     1 
ATOM   2797 O  O     . ARG B 1 221 ? 30.966 -20.910 5.171   1.00 64.80  ? 139 ARG B O     1 
ATOM   2798 C  CB    . ARG B 1 221 ? 30.450 -24.108 4.654   1.00 75.73  ? 139 ARG B CB    1 
ATOM   2799 C  CG    . ARG B 1 221 ? 30.811 -24.357 3.194   1.00 79.31  ? 139 ARG B CG    1 
ATOM   2800 C  CD    . ARG B 1 221 ? 29.729 -25.147 2.465   1.00 92.11  ? 139 ARG B CD    1 
ATOM   2801 N  NE    . ARG B 1 221 ? 29.685 -24.845 1.025   1.00 108.94 ? 139 ARG B NE    1 
ATOM   2802 C  CZ    . ARG B 1 221 ? 28.582 -24.659 0.283   1.00 106.68 ? 139 ARG B CZ    1 
ATOM   2803 N  NH1   . ARG B 1 221 ? 27.381 -24.864 0.804   1.00 105.65 ? 139 ARG B NH1   1 
ATOM   2804 N  NH2   . ARG B 1 221 ? 28.683 -24.301 -0.990  1.00 95.68  ? 139 ARG B NH2   1 
ATOM   2805 N  N     . VAL B 1 222 ? 32.742 -21.736 4.040   1.00 56.96  ? 140 VAL B N     1 
ATOM   2806 C  CA    . VAL B 1 222 ? 33.245 -20.451 3.587   1.00 53.03  ? 140 VAL B CA    1 
ATOM   2807 C  C     . VAL B 1 222 ? 33.372 -20.477 2.068   1.00 47.85  ? 140 VAL B C     1 
ATOM   2808 O  O     . VAL B 1 222 ? 33.978 -21.385 1.543   1.00 49.00  ? 140 VAL B O     1 
ATOM   2809 C  CB    . VAL B 1 222 ? 34.607 -20.222 4.259   1.00 53.22  ? 140 VAL B CB    1 
ATOM   2810 C  CG1   . VAL B 1 222 ? 35.339 -19.037 3.649   1.00 64.04  ? 140 VAL B CG1   1 
ATOM   2811 C  CG2   . VAL B 1 222 ? 34.480 -20.033 5.758   1.00 53.96  ? 140 VAL B CG2   1 
ATOM   2812 N  N     . LEU B 1 223 ? 32.794 -19.508 1.362   1.00 49.74  ? 141 LEU B N     1 
ATOM   2813 C  CA    . LEU B 1 223 ? 33.103 -19.308 -0.046  1.00 56.04  ? 141 LEU B CA    1 
ATOM   2814 C  C     . LEU B 1 223 ? 34.047 -18.115 -0.165  1.00 60.01  ? 141 LEU B C     1 
ATOM   2815 O  O     . LEU B 1 223 ? 33.711 -17.014 0.262   1.00 61.70  ? 141 LEU B O     1 
ATOM   2816 C  CB    . LEU B 1 223 ? 31.860 -19.061 -0.893  1.00 69.70  ? 141 LEU B CB    1 
ATOM   2817 C  CG    . LEU B 1 223 ? 31.043 -20.288 -1.302  1.00 76.57  ? 141 LEU B CG    1 
ATOM   2818 C  CD1   . LEU B 1 223 ? 29.781 -19.766 -1.953  1.00 78.96  ? 141 LEU B CD1   1 
ATOM   2819 C  CD2   . LEU B 1 223 ? 31.769 -21.216 -2.257  1.00 81.07  ? 141 LEU B CD2   1 
ATOM   2820 N  N     . SER B 1 224 ? 35.222 -18.358 -0.758  1.00 66.70  ? 142 SER B N     1 
ATOM   2821 C  CA    . SER B 1 224 ? 36.269 -17.360 -0.916  1.00 53.97  ? 142 SER B CA    1 
ATOM   2822 C  C     . SER B 1 224 ? 36.277 -16.853 -2.350  1.00 48.53  ? 142 SER B C     1 
ATOM   2823 O  O     . SER B 1 224 ? 36.570 -17.627 -3.263  1.00 45.54  ? 142 SER B O     1 
ATOM   2824 C  CB    . SER B 1 224 ? 37.621 -17.919 -0.567  1.00 49.88  ? 142 SER B CB    1 
ATOM   2825 O  OG    . SER B 1 224 ? 38.578 -16.875 -0.619  1.00 48.30  ? 142 SER B OG    1 
ATOM   2826 N  N     . LEU B 1 225 ? 35.974 -15.553 -2.524  1.00 52.08  ? 143 LEU B N     1 
ATOM   2827 C  CA    . LEU B 1 225 ? 36.161 -14.885 -3.809  1.00 51.69  ? 143 LEU B CA    1 
ATOM   2828 C  C     . LEU B 1 225 ? 37.601 -14.392 -3.969  1.00 48.56  ? 143 LEU B C     1 
ATOM   2829 O  O     . LEU B 1 225 ? 38.043 -14.122 -5.087  1.00 51.38  ? 143 LEU B O     1 
ATOM   2830 C  CB    . LEU B 1 225 ? 35.158 -13.748 -3.951  1.00 58.74  ? 143 LEU B CB    1 
ATOM   2831 C  CG    . LEU B 1 225 ? 33.724 -14.173 -4.265  1.00 58.30  ? 143 LEU B CG    1 
ATOM   2832 C  CD1   . LEU B 1 225 ? 32.815 -13.005 -4.043  1.00 62.07  ? 143 LEU B CD1   1 
ATOM   2833 C  CD2   . LEU B 1 225 ? 33.607 -14.684 -5.672  1.00 62.66  ? 143 LEU B CD2   1 
ATOM   2834 N  N     . GLY B 1 226 ? 38.345 -14.362 -2.855  1.00 45.36  ? 144 GLY B N     1 
ATOM   2835 C  CA    . GLY B 1 226 ? 39.723 -13.920 -2.864  1.00 49.80  ? 144 GLY B CA    1 
ATOM   2836 C  C     . GLY B 1 226 ? 39.799 -12.393 -2.950  1.00 51.62  ? 144 GLY B C     1 
ATOM   2837 O  O     . GLY B 1 226 ? 38.790 -11.686 -2.852  1.00 47.77  ? 144 GLY B O     1 
ATOM   2838 N  N     . PRO B 1 227 ? 41.014 -11.837 -3.144  1.00 52.38  ? 145 PRO B N     1 
ATOM   2839 C  CA    . PRO B 1 227 ? 41.190 -10.384 -3.237  1.00 48.93  ? 145 PRO B CA    1 
ATOM   2840 C  C     . PRO B 1 227 ? 40.720 -9.894  -4.598  1.00 44.52  ? 145 PRO B C     1 
ATOM   2841 O  O     . PRO B 1 227 ? 40.455 -10.692 -5.511  1.00 46.47  ? 145 PRO B O     1 
ATOM   2842 C  CB    . PRO B 1 227 ? 42.723 -10.199 -3.035  1.00 48.66  ? 145 PRO B CB    1 
ATOM   2843 C  CG    . PRO B 1 227 ? 43.328 -11.511 -3.498  1.00 42.07  ? 145 PRO B CG    1 
ATOM   2844 C  CD    . PRO B 1 227 ? 42.275 -12.589 -3.297  1.00 46.69  ? 145 PRO B CD    1 
ATOM   2845 N  N     . ASN B 1 228 ? 40.636 -8.570  -4.716  1.00 44.87  ? 146 ASN B N     1 
ATOM   2846 C  CA    . ASN B 1 228 ? 40.447 -7.942  -6.015  1.00 53.14  ? 146 ASN B CA    1 
ATOM   2847 C  C     . ASN B 1 228 ? 39.101 -8.384  -6.593  1.00 53.68  ? 146 ASN B C     1 
ATOM   2848 O  O     . ASN B 1 228 ? 39.028 -8.750  -7.782  1.00 50.81  ? 146 ASN B O     1 
ATOM   2849 C  CB    . ASN B 1 228 ? 41.612 -8.261  -6.950  1.00 49.47  ? 146 ASN B CB    1 
ATOM   2850 C  CG    . ASN B 1 228 ? 41.600 -7.460  -8.228  1.00 44.06  ? 146 ASN B CG    1 
ATOM   2851 O  OD1   . ASN B 1 228 ? 41.150 -6.311  -8.259  1.00 43.27  ? 146 ASN B OD1   1 
ATOM   2852 N  ND2   . ASN B 1 228 ? 42.177 -8.029  -9.275  1.00 40.75  ? 146 ASN B ND2   1 
ATOM   2853 N  N     . THR B 1 229 ? 38.066 -8.310  -5.729  1.00 52.04  ? 147 THR B N     1 
ATOM   2854 C  CA    . THR B 1 229 ? 36.692 -8.683  -6.060  1.00 52.88  ? 147 THR B CA    1 
ATOM   2855 C  C     . THR B 1 229 ? 35.843 -7.427  -6.233  1.00 49.63  ? 147 THR B C     1 
ATOM   2856 O  O     . THR B 1 229 ? 35.554 -6.725  -5.259  1.00 54.90  ? 147 THR B O     1 
ATOM   2857 C  CB    . THR B 1 229 ? 36.126 -9.561  -4.948  1.00 53.57  ? 147 THR B CB    1 
ATOM   2858 O  OG1   . THR B 1 229 ? 36.986 -10.686 -4.823  1.00 54.28  ? 147 THR B OG1   1 
ATOM   2859 C  CG2   . THR B 1 229 ? 34.730 -10.050 -5.263  1.00 56.58  ? 147 THR B CG2   1 
ATOM   2860 N  N     . PRO B 1 230 ? 35.405 -7.088  -7.464  1.00 46.16  ? 148 PRO B N     1 
ATOM   2861 C  CA    . PRO B 1 230 ? 34.421 -6.017  -7.641  1.00 48.98  ? 148 PRO B CA    1 
ATOM   2862 C  C     . PRO B 1 230 ? 33.202 -6.178  -6.724  1.00 47.68  ? 148 PRO B C     1 
ATOM   2863 O  O     . PRO B 1 230 ? 32.801 -7.289  -6.368  1.00 53.29  ? 148 PRO B O     1 
ATOM   2864 C  CB    . PRO B 1 230 ? 34.057 -6.121  -9.130  1.00 54.11  ? 148 PRO B CB    1 
ATOM   2865 C  CG    . PRO B 1 230 ? 35.272 -6.783  -9.783  1.00 51.85  ? 148 PRO B CG    1 
ATOM   2866 C  CD    . PRO B 1 230 ? 35.753 -7.762  -8.726  1.00 50.73  ? 148 PRO B CD    1 
ATOM   2867 N  N     . LEU B 1 231 ? 32.624 -5.051  -6.298  1.00 54.28  ? 149 LEU B N     1 
ATOM   2868 C  CA    . LEU B 1 231 ? 31.517 -5.077  -5.352  1.00 55.35  ? 149 LEU B CA    1 
ATOM   2869 C  C     . LEU B 1 231 ? 30.303 -5.773  -5.976  1.00 56.11  ? 149 LEU B C     1 
ATOM   2870 O  O     . LEU B 1 231 ? 29.689 -6.621  -5.337  1.00 57.03  ? 149 LEU B O     1 
ATOM   2871 C  CB    . LEU B 1 231 ? 31.176 -3.678  -4.861  1.00 52.12  ? 149 LEU B CB    1 
ATOM   2872 C  CG    . LEU B 1 231 ? 30.587 -3.645  -3.453  1.00 61.07  ? 149 LEU B CG    1 
ATOM   2873 C  CD1   . LEU B 1 231 ? 31.570 -4.105  -2.397  1.00 60.92  ? 149 LEU B CD1   1 
ATOM   2874 C  CD2   . LEU B 1 231 ? 30.097 -2.265  -3.116  1.00 76.73  ? 149 LEU B CD2   1 
ATOM   2875 N  N     . PHE B 1 232 ? 30.008 -5.468  -7.244  1.00 55.19  ? 150 PHE B N     1 
ATOM   2876 C  CA    . PHE B 1 232 ? 29.017 -6.207  -8.008  1.00 55.08  ? 150 PHE B CA    1 
ATOM   2877 C  C     . PHE B 1 232 ? 29.318 -7.704  -8.098  1.00 60.60  ? 150 PHE B C     1 
ATOM   2878 O  O     . PHE B 1 232 ? 28.424 -8.538  -8.255  1.00 60.16  ? 150 PHE B O     1 
ATOM   2879 C  CB    . PHE B 1 232 ? 28.911 -5.577  -9.396  1.00 57.03  ? 150 PHE B CB    1 
ATOM   2880 C  CG    . PHE B 1 232 ? 30.040 -5.740  -10.400 1.00 55.77  ? 150 PHE B CG    1 
ATOM   2881 C  CD1   . PHE B 1 232 ? 30.156 -6.894  -11.163 1.00 56.41  ? 150 PHE B CD1   1 
ATOM   2882 C  CD2   . PHE B 1 232 ? 30.893 -4.677  -10.687 1.00 57.63  ? 150 PHE B CD2   1 
ATOM   2883 C  CE1   . PHE B 1 232 ? 31.142 -6.999  -12.135 1.00 55.59  ? 150 PHE B CE1   1 
ATOM   2884 C  CE2   . PHE B 1 232 ? 31.889 -4.796  -11.647 1.00 52.51  ? 150 PHE B CE2   1 
ATOM   2885 C  CZ    . PHE B 1 232 ? 32.002 -5.954  -12.374 1.00 56.34  ? 150 PHE B CZ    1 
ATOM   2886 N  N     . SER B 1 233 ? 30.586 -8.078  -8.036  1.00 63.56  ? 151 SER B N     1 
ATOM   2887 C  CA    . SER B 1 233 ? 30.890 -9.493  -8.120  1.00 60.14  ? 151 SER B CA    1 
ATOM   2888 C  C     . SER B 1 233 ? 30.555 -10.169 -6.793  1.00 54.45  ? 151 SER B C     1 
ATOM   2889 O  O     . SER B 1 233 ? 30.194 -11.335 -6.778  1.00 53.64  ? 151 SER B O     1 
ATOM   2890 C  CB    . SER B 1 233 ? 32.303 -9.725  -8.599  1.00 56.01  ? 151 SER B CB    1 
ATOM   2891 O  OG    . SER B 1 233 ? 32.341 -9.539  -10.009 1.00 61.33  ? 151 SER B OG    1 
ATOM   2892 N  N     . PHE B 1 234 ? 30.631 -9.432  -5.683  1.00 58.32  ? 152 PHE B N     1 
ATOM   2893 C  CA    . PHE B 1 234 ? 30.130 -9.944  -4.414  1.00 61.39  ? 152 PHE B CA    1 
ATOM   2894 C  C     . PHE B 1 234 ? 28.617 -10.175 -4.495  1.00 62.64  ? 152 PHE B C     1 
ATOM   2895 O  O     . PHE B 1 234 ? 28.146 -11.236 -4.090  1.00 66.50  ? 152 PHE B O     1 
ATOM   2896 C  CB    . PHE B 1 234 ? 30.347 -9.021  -3.211  1.00 60.44  ? 152 PHE B CB    1 
ATOM   2897 C  CG    . PHE B 1 234 ? 31.714 -9.047  -2.543  1.00 63.18  ? 152 PHE B CG    1 
ATOM   2898 C  CD1   . PHE B 1 234 ? 32.779 -8.295  -3.052  1.00 63.09  ? 152 PHE B CD1   1 
ATOM   2899 C  CD2   . PHE B 1 234 ? 31.904 -9.742  -1.350  1.00 52.54  ? 152 PHE B CD2   1 
ATOM   2900 C  CE1   . PHE B 1 234 ? 34.002 -8.277  -2.399  1.00 54.09  ? 152 PHE B CE1   1 
ATOM   2901 C  CE2   . PHE B 1 234 ? 33.134 -9.718  -0.705  1.00 55.11  ? 152 PHE B CE2   1 
ATOM   2902 C  CZ    . PHE B 1 234 ? 34.175 -8.985  -1.228  1.00 54.41  ? 152 PHE B CZ    1 
ATOM   2903 N  N     . ALA B 1 235 ? 27.865 -9.176  -4.981  1.00 50.59  ? 153 ALA B N     1 
ATOM   2904 C  CA    . ALA B 1 235 ? 26.411 -9.286  -5.098  1.00 59.78  ? 153 ALA B CA    1 
ATOM   2905 C  C     . ALA B 1 235 ? 26.023 -10.453 -6.009  1.00 61.46  ? 153 ALA B C     1 
ATOM   2906 O  O     . ALA B 1 235 ? 25.157 -11.250 -5.652  1.00 61.10  ? 153 ALA B O     1 
ATOM   2907 C  CB    . ALA B 1 235 ? 25.794 -7.990  -5.590  1.00 60.27  ? 153 ALA B CB    1 
ATOM   2908 N  N     . ASP B 1 236 ? 26.684 -10.594 -7.164  1.00 56.68  ? 154 ASP B N     1 
ATOM   2909 C  CA    . ASP B 1 236 ? 26.367 -11.706 -8.033  1.00 58.06  ? 154 ASP B CA    1 
ATOM   2910 C  C     . ASP B 1 236 ? 26.335 -12.963 -7.174  1.00 61.79  ? 154 ASP B C     1 
ATOM   2911 O  O     . ASP B 1 236 ? 25.389 -13.740 -7.247  1.00 73.88  ? 154 ASP B O     1 
ATOM   2912 C  CB    . ASP B 1 236 ? 27.352 -11.850 -9.180  1.00 62.36  ? 154 ASP B CB    1 
ATOM   2913 C  CG    . ASP B 1 236 ? 27.307 -10.756 -10.236 1.00 67.78  ? 154 ASP B CG    1 
ATOM   2914 O  OD1   . ASP B 1 236 ? 26.274 -10.069 -10.295 1.00 59.51  ? 154 ASP B OD1   1 
ATOM   2915 O  OD2   . ASP B 1 236 ? 28.311 -10.598 -10.982 1.00 78.36  ? 154 ASP B OD2   1 
ATOM   2916 N  N     . ALA B 1 237 ? 27.367 -13.131 -6.345  1.00 54.91  ? 155 ALA B N     1 
ATOM   2917 C  CA    . ALA B 1 237 ? 27.561 -14.376 -5.626  1.00 59.32  ? 155 ALA B CA    1 
ATOM   2918 C  C     . ALA B 1 237 ? 26.583 -14.516 -4.461  1.00 67.12  ? 155 ALA B C     1 
ATOM   2919 O  O     . ALA B 1 237 ? 26.333 -15.631 -4.017  1.00 72.58  ? 155 ALA B O     1 
ATOM   2920 C  CB    . ALA B 1 237 ? 28.983 -14.468 -5.120  1.00 64.44  ? 155 ALA B CB    1 
ATOM   2921 N  N     . VAL B 1 238 ? 26.064 -13.393 -3.966  1.00 67.41  ? 156 VAL B N     1 
ATOM   2922 C  CA    . VAL B 1 238 ? 25.061 -13.411 -2.860  1.00 74.55  ? 156 VAL B CA    1 
ATOM   2923 C  C     . VAL B 1 238 ? 23.718 -13.886 -3.435  1.00 74.88  ? 156 VAL B C     1 
ATOM   2924 O  O     . VAL B 1 238 ? 22.965 -14.560 -2.712  1.00 64.72  ? 156 VAL B O     1 
ATOM   2925 C  CB    . VAL B 1 238 ? 24.938 -12.013 -2.224  1.00 68.58  ? 156 VAL B CB    1 
ATOM   2926 C  CG1   . VAL B 1 238 ? 23.714 -11.876 -1.327  1.00 68.57  ? 156 VAL B CG1   1 
ATOM   2927 C  CG2   . VAL B 1 238 ? 26.197 -11.609 -1.472  1.00 66.65  ? 156 VAL B CG2   1 
ATOM   2928 N  N     . ARG B 1 239 ? 23.437 -13.535 -4.688  1.00 68.98  ? 157 ARG B N     1 
ATOM   2929 C  CA    . ARG B 1 239 ? 22.186 -13.985 -5.343  1.00 71.55  ? 157 ARG B CA    1 
ATOM   2930 C  C     . ARG B 1 239 ? 22.217 -15.511 -5.359  1.00 79.41  ? 157 ARG B C     1 
ATOM   2931 O  O     . ARG B 1 239 ? 21.195 -16.124 -5.001  1.00 79.98  ? 157 ARG B O     1 
ATOM   2932 C  CB    . ARG B 1 239 ? 22.070 -13.347 -6.728  1.00 72.44  ? 157 ARG B CB    1 
ATOM   2933 C  CG    . ARG B 1 239 ? 21.914 -11.838 -6.649  1.00 69.36  ? 157 ARG B CG    1 
ATOM   2934 C  CD    . ARG B 1 239 ? 21.650 -11.209 -8.001  1.00 77.55  ? 157 ARG B CD    1 
ATOM   2935 N  NE    . ARG B 1 239 ? 21.572 -9.748  -7.901  1.00 82.02  ? 157 ARG B NE    1 
ATOM   2936 C  CZ    . ARG B 1 239 ? 22.614 -8.940  -8.019  1.00 80.70  ? 157 ARG B CZ    1 
ATOM   2937 N  NH1   . ARG B 1 239 ? 23.629 -9.284  -8.789  1.00 71.93  ? 157 ARG B NH1   1 
ATOM   2938 N  NH2   . ARG B 1 239 ? 22.634 -7.793  -7.367  1.00 73.08  ? 157 ARG B NH2   1 
ATOM   2939 N  N     . ARG B 1 240 ? 23.341 -16.097 -5.764  1.00 70.56  ? 158 ARG B N     1 
ATOM   2940 C  CA    . ARG B 1 240 ? 23.488 -17.566 -5.655  1.00 70.99  ? 158 ARG B CA    1 
ATOM   2941 C  C     . ARG B 1 240 ? 23.963 -17.825 -4.230  1.00 65.56  ? 158 ARG B C     1 
ATOM   2942 O  O     . ARG B 1 240 ? 24.080 -16.856 -3.496  1.00 89.00  ? 158 ARG B O     1 
ATOM   2943 C  CB    . ARG B 1 240 ? 24.547 -18.066 -6.637  1.00 78.57  ? 158 ARG B CB    1 
ATOM   2944 C  CG    . ARG B 1 240 ? 24.122 -19.264 -7.471  1.00 90.30  ? 158 ARG B CG    1 
ATOM   2945 C  CD    . ARG B 1 240 ? 25.313 -20.112 -7.875  1.00 91.51  ? 158 ARG B CD    1 
ATOM   2946 N  NE    . ARG B 1 240 ? 25.168 -21.502 -7.432  1.00 96.80  ? 158 ARG B NE    1 
ATOM   2947 C  CZ    . ARG B 1 240 ? 25.977 -22.489 -7.789  1.00 87.60  ? 158 ARG B CZ    1 
ATOM   2948 N  NH1   . ARG B 1 240 ? 25.997 -23.610 -7.094  1.00 85.38  ? 158 ARG B NH1   1 
ATOM   2949 N  NH2   . ARG B 1 240 ? 26.766 -22.350 -8.837  1.00 81.53  ? 158 ARG B NH2   1 
ATOM   2950 N  N     . PHE B 1 241 ? 24.150 -19.068 -3.818  1.00 59.34  ? 159 PHE B N     1 
ATOM   2951 C  CA    . PHE B 1 241 ? 24.759 -19.354 -2.486  1.00 69.28  ? 159 PHE B CA    1 
ATOM   2952 C  C     . PHE B 1 241 ? 23.921 -18.841 -1.299  1.00 62.85  ? 159 PHE B C     1 
ATOM   2953 O  O     . PHE B 1 241 ? 23.890 -19.541 -0.277  1.00 64.80  ? 159 PHE B O     1 
ATOM   2954 C  CB    . PHE B 1 241 ? 26.183 -18.793 -2.535  1.00 67.30  ? 159 PHE B CB    1 
ATOM   2955 C  CG    . PHE B 1 241 ? 26.992 -19.293 -3.723  1.00 70.57  ? 159 PHE B CG    1 
ATOM   2956 C  CD1   . PHE B 1 241 ? 27.043 -20.646 -4.031  1.00 63.44  ? 159 PHE B CD1   1 
ATOM   2957 C  CD2   . PHE B 1 241 ? 27.701 -18.410 -4.525  1.00 63.23  ? 159 PHE B CD2   1 
ATOM   2958 C  CE1   . PHE B 1 241 ? 27.785 -21.097 -5.108  1.00 69.57  ? 159 PHE B CE1   1 
ATOM   2959 C  CE2   . PHE B 1 241 ? 28.439 -18.869 -5.600  1.00 61.05  ? 159 PHE B CE2   1 
ATOM   2960 C  CZ    . PHE B 1 241 ? 28.479 -20.209 -5.890  1.00 61.64  ? 159 PHE B CZ    1 
ATOM   2961 N  N     . SER B 1 242 ? 23.289 -17.678 -1.415  1.00 63.80  ? 160 SER B N     1 
ATOM   2962 C  CA    . SER B 1 242 ? 22.466 -17.096 -0.326  1.00 72.91  ? 160 SER B CA    1 
ATOM   2963 C  C     . SER B 1 242 ? 23.213 -17.199 1.009   1.00 69.47  ? 160 SER B C     1 
ATOM   2964 O  O     . SER B 1 242 ? 22.766 -17.949 1.893   1.00 68.11  ? 160 SER B O     1 
ATOM   2965 C  CB    . SER B 1 242 ? 21.108 -17.738 -0.260  1.00 67.95  ? 160 SER B CB    1 
ATOM   2966 O  OG    . SER B 1 242 ? 20.136 -16.926 -0.901  1.00 71.54  ? 160 SER B OG    1 
ATOM   2967 N  N     . PRO B 1 243 ? 24.314 -16.447 1.196   1.00 74.36  ? 161 PRO B N     1 
ATOM   2968 C  CA    . PRO B 1 243 ? 25.072 -16.525 2.431   1.00 71.41  ? 161 PRO B CA    1 
ATOM   2969 C  C     . PRO B 1 243 ? 24.405 -15.835 3.610   1.00 63.44  ? 161 PRO B C     1 
ATOM   2970 O  O     . PRO B 1 243 ? 23.573 -14.944 3.409   1.00 62.22  ? 161 PRO B O     1 
ATOM   2971 C  CB    . PRO B 1 243 ? 26.384 -15.852 2.021   1.00 67.72  ? 161 PRO B CB    1 
ATOM   2972 C  CG    . PRO B 1 243 ? 25.978 -14.832 0.991   1.00 70.62  ? 161 PRO B CG    1 
ATOM   2973 C  CD    . PRO B 1 243 ? 24.860 -15.509 0.230   1.00 76.24  ? 161 PRO B CD    1 
ATOM   2974 N  N     . GLN B 1 244 ? 24.756 -16.256 4.821   1.00 60.00  ? 162 GLN B N     1 
ATOM   2975 C  CA    . GLN B 1 244 ? 24.202 -15.639 6.047   1.00 63.67  ? 162 GLN B CA    1 
ATOM   2976 C  C     . GLN B 1 244 ? 25.149 -14.512 6.443   1.00 68.59  ? 162 GLN B C     1 
ATOM   2977 O  O     . GLN B 1 244 ? 24.698 -13.553 7.092   1.00 73.11  ? 162 GLN B O     1 
ATOM   2978 C  CB    . GLN B 1 244 ? 24.154 -16.739 7.103   1.00 68.40  ? 162 GLN B CB    1 
ATOM   2979 C  CG    . GLN B 1 244 ? 23.015 -17.737 6.923   1.00 71.72  ? 162 GLN B CG    1 
ATOM   2980 C  CD    . GLN B 1 244 ? 23.237 -18.715 5.790   1.00 85.35  ? 162 GLN B CD    1 
ATOM   2981 O  OE1   . GLN B 1 244 ? 24.140 -19.556 5.830   1.00 85.79  ? 162 GLN B OE1   1 
ATOM   2982 N  NE2   . GLN B 1 244 ? 22.415 -18.608 4.758   1.00 83.11  ? 162 GLN B NE2   1 
ATOM   2983 N  N     . LEU B 1 245 ? 26.408 -14.633 6.044   1.00 75.80  ? 163 LEU B N     1 
ATOM   2984 C  CA    . LEU B 1 245 ? 27.444 -13.653 6.336   1.00 68.85  ? 163 LEU B CA    1 
ATOM   2985 C  C     . LEU B 1 245 ? 28.198 -13.264 5.066   1.00 66.14  ? 163 LEU B C     1 
ATOM   2986 O  O     . LEU B 1 245 ? 28.524 -14.120 4.254   1.00 74.01  ? 163 LEU B O     1 
ATOM   2987 C  CB    . LEU B 1 245 ? 28.408 -14.288 7.331   1.00 63.59  ? 163 LEU B CB    1 
ATOM   2988 C  CG    . LEU B 1 245 ? 29.457 -13.356 7.933   1.00 61.63  ? 163 LEU B CG    1 
ATOM   2989 C  CD1   . LEU B 1 245 ? 28.786 -12.127 8.503   1.00 64.68  ? 163 LEU B CD1   1 
ATOM   2990 C  CD2   . LEU B 1 245 ? 30.280 -14.060 9.010   1.00 62.07  ? 163 LEU B CD2   1 
ATOM   2991 N  N     . VAL B 1 246 ? 28.477 -11.968 4.911   1.00 63.87  ? 164 VAL B N     1 
ATOM   2992 C  CA    . VAL B 1 246 ? 29.493 -11.490 3.986   1.00 61.91  ? 164 VAL B CA    1 
ATOM   2993 C  C     . VAL B 1 246 ? 30.600 -10.782 4.766   1.00 59.31  ? 164 VAL B C     1 
ATOM   2994 O  O     . VAL B 1 246 ? 30.317 -9.868  5.530   1.00 62.52  ? 164 VAL B O     1 
ATOM   2995 C  CB    . VAL B 1 246 ? 28.894 -10.546 2.938   1.00 58.05  ? 164 VAL B CB    1 
ATOM   2996 C  CG1   . VAL B 1 246 ? 29.987 -9.968  2.057   1.00 60.84  ? 164 VAL B CG1   1 
ATOM   2997 C  CG2   . VAL B 1 246 ? 27.843 -11.258 2.099   1.00 61.08  ? 164 VAL B CG2   1 
ATOM   2998 N  N     . CYS B 1 247 ? 31.854 -11.209 4.558   1.00 65.13  ? 165 CYS B N     1 
ATOM   2999 C  CA    . CYS B 1 247 ? 33.028 -10.624 5.199   1.00 61.28  ? 165 CYS B CA    1 
ATOM   3000 C  C     . CYS B 1 247 ? 33.885 -9.886  4.172   1.00 54.98  ? 165 CYS B C     1 
ATOM   3001 O  O     . CYS B 1 247 ? 34.099 -10.386 3.077   1.00 58.26  ? 165 CYS B O     1 
ATOM   3002 C  CB    . CYS B 1 247 ? 33.898 -11.706 5.813   1.00 62.78  ? 165 CYS B CB    1 
ATOM   3003 S  SG    . CYS B 1 247 ? 33.155 -12.466 7.270   1.00 60.62  ? 165 CYS B SG    1 
ATOM   3004 N  N     . ILE B 1 248 ? 34.357 -8.686  4.512   1.00 57.80  ? 166 ILE B N     1 
ATOM   3005 C  CA    . ILE B 1 248 ? 35.211 -7.915  3.618   1.00 52.24  ? 166 ILE B CA    1 
ATOM   3006 C  C     . ILE B 1 248 ? 36.418 -7.404  4.390   1.00 51.98  ? 166 ILE B C     1 
ATOM   3007 O  O     . ILE B 1 248 ? 36.259 -6.712  5.400   1.00 50.03  ? 166 ILE B O     1 
ATOM   3008 C  CB    . ILE B 1 248 ? 34.445 -6.747  3.002   1.00 54.09  ? 166 ILE B CB    1 
ATOM   3009 C  CG1   . ILE B 1 248 ? 33.196 -7.230  2.233   1.00 63.37  ? 166 ILE B CG1   1 
ATOM   3010 C  CG2   . ILE B 1 248 ? 35.400 -5.939  2.138   1.00 52.61  ? 166 ILE B CG2   1 
ATOM   3011 C  CD1   . ILE B 1 248 ? 32.293 -6.120  1.716   1.00 62.35  ? 166 ILE B CD1   1 
ATOM   3012 N  N     . SER B 1 249 ? 37.604 -7.830  3.934   1.00 54.91  ? 167 SER B N     1 
ATOM   3013 C  CA    . SER B 1 249 ? 38.879 -7.265  4.356   1.00 51.33  ? 167 SER B CA    1 
ATOM   3014 C  C     . SER B 1 249 ? 39.282 -6.228  3.329   1.00 47.98  ? 167 SER B C     1 
ATOM   3015 O  O     . SER B 1 249 ? 39.158 -6.497  2.131   1.00 48.01  ? 167 SER B O     1 
ATOM   3016 C  CB    . SER B 1 249 ? 39.978 -8.282  4.482   1.00 49.17  ? 167 SER B CB    1 
ATOM   3017 O  OG    . SER B 1 249 ? 41.174 -7.661  4.946   1.00 51.55  ? 167 SER B OG    1 
ATOM   3018 N  N     . ALA B 1 250 ? 39.735 -5.067  3.815   1.00 47.11  ? 168 ALA B N     1 
ATOM   3019 C  CA    . ALA B 1 250 ? 40.168 -3.985  2.937   1.00 50.67  ? 168 ALA B CA    1 
ATOM   3020 C  C     . ALA B 1 250 ? 41.344 -3.236  3.566   1.00 49.98  ? 168 ALA B C     1 
ATOM   3021 O  O     . ALA B 1 250 ? 41.295 -2.808  4.729   1.00 53.02  ? 168 ALA B O     1 
ATOM   3022 C  CB    . ALA B 1 250 ? 39.009 -3.074  2.575   1.00 48.54  ? 168 ALA B CB    1 
ATOM   3023 N  N     . THR B 1 251 ? 42.422 -3.149  2.777   1.00 47.89  ? 169 THR B N     1 
ATOM   3024 C  CA    . THR B 1 251 ? 43.660 -2.508  3.186   1.00 51.32  ? 169 THR B CA    1 
ATOM   3025 C  C     . THR B 1 251 ? 43.887 -1.240  2.351   1.00 52.58  ? 169 THR B C     1 
ATOM   3026 O  O     . THR B 1 251 ? 44.194 -0.188  2.895   1.00 47.78  ? 169 THR B O     1 
ATOM   3027 C  CB    . THR B 1 251 ? 44.757 -3.561  3.053   1.00 51.94  ? 169 THR B CB    1 
ATOM   3028 O  OG1   . THR B 1 251 ? 44.480 -4.575  4.028   1.00 47.74  ? 169 THR B OG1   1 
ATOM   3029 C  CG2   . THR B 1 251 ? 46.143 -2.986  3.289   1.00 51.10  ? 169 THR B CG2   1 
ATOM   3030 N  N     . ILE B 1 252 ? 43.669 -1.346  1.035   1.00 61.33  ? 170 ILE B N     1 
ATOM   3031 C  CA    . ILE B 1 252 ? 43.853 -0.282  0.063   1.00 57.94  ? 170 ILE B CA    1 
ATOM   3032 C  C     . ILE B 1 252 ? 42.513 -0.057  -0.632  1.00 58.40  ? 170 ILE B C     1 
ATOM   3033 O  O     . ILE B 1 252 ? 42.045 -0.958  -1.319  1.00 59.89  ? 170 ILE B O     1 
ATOM   3034 C  CB    . ILE B 1 252 ? 44.952 -0.682  -0.956  1.00 62.66  ? 170 ILE B CB    1 
ATOM   3035 C  CG1   . ILE B 1 252 ? 46.295 -0.108  -0.576  1.00 62.14  ? 170 ILE B CG1   1 
ATOM   3036 C  CG2   . ILE B 1 252 ? 44.623 -0.289  -2.404  1.00 65.66  ? 170 ILE B CG2   1 
ATOM   3037 C  CD1   . ILE B 1 252 ? 46.840 -0.664  0.709   1.00 66.68  ? 170 ILE B CD1   1 
ATOM   3038 N  N     . VAL B 1 253 ? 41.932 1.149   -0.509  1.00 58.70  ? 171 VAL B N     1 
ATOM   3039 C  CA    . VAL B 1 253 ? 40.728 1.497   -1.248  1.00 55.37  ? 171 VAL B CA    1 
ATOM   3040 C  C     . VAL B 1 253 ? 40.790 2.938   -1.728  1.00 53.38  ? 171 VAL B C     1 
ATOM   3041 O  O     . VAL B 1 253 ? 40.877 3.843   -0.920  1.00 54.27  ? 171 VAL B O     1 
ATOM   3042 C  CB    . VAL B 1 253 ? 39.440 1.333   -0.428  1.00 56.05  ? 171 VAL B CB    1 
ATOM   3043 C  CG1   . VAL B 1 253 ? 38.237 1.692   -1.292  1.00 58.15  ? 171 VAL B CG1   1 
ATOM   3044 C  CG2   . VAL B 1 253 ? 39.293 -0.074  0.147   1.00 60.51  ? 171 VAL B CG2   1 
ATOM   3045 N  N     . HIS B 1 254 ? 40.640 3.161   -3.031  1.00 54.48  ? 172 HIS B N     1 
ATOM   3046 C  CA    . HIS B 1 254 ? 40.737 4.525   -3.520  1.00 65.30  ? 172 HIS B CA    1 
ATOM   3047 C  C     . HIS B 1 254 ? 39.572 4.847   -4.459  1.00 62.03  ? 172 HIS B C     1 
ATOM   3048 O  O     . HIS B 1 254 ? 39.399 6.012   -4.820  1.00 55.84  ? 172 HIS B O     1 
ATOM   3049 C  CB    . HIS B 1 254 ? 42.097 4.812   -4.194  1.00 74.48  ? 172 HIS B CB    1 
ATOM   3050 C  CG    . HIS B 1 254 ? 43.356 4.600   -3.385  1.00 77.34  ? 172 HIS B CG    1 
ATOM   3051 N  ND1   . HIS B 1 254 ? 43.779 5.454   -2.387  1.00 82.26  ? 172 HIS B ND1   1 
ATOM   3052 C  CD2   . HIS B 1 254 ? 44.312 3.648   -3.463  1.00 74.43  ? 172 HIS B CD2   1 
ATOM   3053 C  CE1   . HIS B 1 254 ? 44.922 5.005   -1.860  1.00 77.72  ? 172 HIS B CE1   1 
ATOM   3054 N  NE2   . HIS B 1 254 ? 45.264 3.915   -2.499  1.00 72.73  ? 172 HIS B NE2   1 
ATOM   3055 N  N     . ASP B 1 255 ? 38.779 3.846   -4.870  1.00 53.36  ? 173 ASP B N     1 
ATOM   3056 C  CA    . ASP B 1 255 ? 37.857 4.074   -5.968  1.00 54.01  ? 173 ASP B CA    1 
ATOM   3057 C  C     . ASP B 1 255 ? 36.494 4.548   -5.457  1.00 59.35  ? 173 ASP B C     1 
ATOM   3058 O  O     . ASP B 1 255 ? 35.464 3.976   -5.801  1.00 65.55  ? 173 ASP B O     1 
ATOM   3059 C  CB    . ASP B 1 255 ? 37.703 2.845   -6.835  1.00 50.66  ? 173 ASP B CB    1 
ATOM   3060 C  CG    . ASP B 1 255 ? 37.087 3.149   -8.188  1.00 54.95  ? 173 ASP B CG    1 
ATOM   3061 O  OD1   . ASP B 1 255 ? 37.043 4.357   -8.568  1.00 55.10  ? 173 ASP B OD1   1 
ATOM   3062 O  OD2   . ASP B 1 255 ? 36.627 2.177   -8.827  1.00 63.04  ? 173 ASP B OD2   1 
ATOM   3063 N  N     . LEU B 1 256 ? 36.502 5.623   -4.667  1.00 55.74  ? 174 LEU B N     1 
ATOM   3064 C  CA    . LEU B 1 256 ? 35.377 6.008   -3.833  1.00 58.74  ? 174 LEU B CA    1 
ATOM   3065 C  C     . LEU B 1 256 ? 34.089 6.222   -4.639  1.00 61.08  ? 174 LEU B C     1 
ATOM   3066 O  O     . LEU B 1 256 ? 33.013 5.818   -4.197  1.00 52.86  ? 174 LEU B O     1 
ATOM   3067 C  CB    . LEU B 1 256 ? 35.753 7.279   -3.074  1.00 57.24  ? 174 LEU B CB    1 
ATOM   3068 C  CG    . LEU B 1 256 ? 36.861 7.170   -2.028  1.00 58.82  ? 174 LEU B CG    1 
ATOM   3069 C  CD1   . LEU B 1 256 ? 36.810 8.377   -1.118  1.00 59.77  ? 174 LEU B CD1   1 
ATOM   3070 C  CD2   . LEU B 1 256 ? 36.760 5.910   -1.203  1.00 68.49  ? 174 LEU B CD2   1 
ATOM   3071 N  N     . GLU B 1 257 ? 34.173 6.874   -5.807  1.00 62.34  ? 175 GLU B N     1 
ATOM   3072 C  CA    . GLU B 1 257 ? 32.951 7.283   -6.484  1.00 59.78  ? 175 GLU B CA    1 
ATOM   3073 C  C     . GLU B 1 257 ? 32.284 6.040   -7.059  1.00 60.85  ? 175 GLU B C     1 
ATOM   3074 O  O     . GLU B 1 257 ? 31.062 5.999   -7.113  1.00 70.43  ? 175 GLU B O     1 
ATOM   3075 C  CB    . GLU B 1 257 ? 33.095 8.422   -7.496  1.00 51.25  ? 175 GLU B CB    1 
ATOM   3076 C  CG    . GLU B 1 257 ? 31.922 8.529   -8.469  1.00 59.91  ? 175 GLU B CG    1 
ATOM   3077 C  CD    . GLU B 1 257 ? 31.917 9.799   -9.301  1.00 66.87  ? 175 GLU B CD    1 
ATOM   3078 O  OE1   . GLU B 1 257 ? 32.569 10.720  -8.753  1.00 70.70  ? 175 GLU B OE1   1 
ATOM   3079 O  OE2   . GLU B 1 257 ? 31.332 9.900   -10.435 1.00 60.11  ? 175 GLU B OE2   1 
ATOM   3080 N  N     . ARG B 1 258 ? 33.069 5.038   -7.472  1.00 60.07  ? 176 ARG B N     1 
ATOM   3081 C  CA    . ARG B 1 258 ? 32.485 3.803   -7.976  1.00 69.80  ? 176 ARG B CA    1 
ATOM   3082 C  C     . ARG B 1 258 ? 31.844 3.010   -6.832  1.00 73.68  ? 176 ARG B C     1 
ATOM   3083 O  O     . ARG B 1 258 ? 30.695 2.587   -6.947  1.00 68.68  ? 176 ARG B O     1 
ATOM   3084 C  CB    . ARG B 1 258 ? 33.450 2.886   -8.731  1.00 67.23  ? 176 ARG B CB    1 
ATOM   3085 C  CG    . ARG B 1 258 ? 32.800 1.547   -9.046  1.00 68.69  ? 176 ARG B CG    1 
ATOM   3086 C  CD    . ARG B 1 258 ? 33.594 0.745   -10.040 1.00 68.50  ? 176 ARG B CD    1 
ATOM   3087 N  NE    . ARG B 1 258 ? 33.571 1.390   -11.354 1.00 70.60  ? 176 ARG B NE    1 
ATOM   3088 C  CZ    . ARG B 1 258 ? 34.581 2.002   -11.955 1.00 72.33  ? 176 ARG B CZ    1 
ATOM   3089 N  NH1   . ARG B 1 258 ? 35.731 2.202   -11.339 1.00 69.54  ? 176 ARG B NH1   1 
ATOM   3090 N  NH2   . ARG B 1 258 ? 34.412 2.466   -13.174 1.00 75.57  ? 176 ARG B NH2   1 
ATOM   3091 N  N     . LEU B 1 259 ? 32.587 2.800   -5.743  1.00 67.48  ? 177 LEU B N     1 
ATOM   3092 C  CA    . LEU B 1 259 ? 32.071 2.048   -4.614  1.00 64.81  ? 177 LEU B CA    1 
ATOM   3093 C  C     . LEU B 1 259 ? 30.808 2.724   -4.071  1.00 69.01  ? 177 LEU B C     1 
ATOM   3094 O  O     . LEU B 1 259 ? 29.806 2.055   -3.845  1.00 76.44  ? 177 LEU B O     1 
ATOM   3095 C  CB    . LEU B 1 259 ? 33.170 1.878   -3.564  1.00 60.41  ? 177 LEU B CB    1 
ATOM   3096 C  CG    . LEU B 1 259 ? 34.377 1.023   -3.995  1.00 61.35  ? 177 LEU B CG    1 
ATOM   3097 C  CD1   . LEU B 1 259 ? 35.501 1.006   -2.964  1.00 57.29  ? 177 LEU B CD1   1 
ATOM   3098 C  CD2   . LEU B 1 259 ? 33.997 -0.409  -4.294  1.00 56.86  ? 177 LEU B CD2   1 
ATOM   3099 N  N     . ARG B 1 260 ? 30.826 4.054   -3.928  1.00 70.50  ? 178 ARG B N     1 
ATOM   3100 C  CA    . ARG B 1 260 ? 29.649 4.826   -3.539  1.00 68.42  ? 178 ARG B CA    1 
ATOM   3101 C  C     . ARG B 1 260 ? 28.396 4.443   -4.331  1.00 71.13  ? 178 ARG B C     1 
ATOM   3102 O  O     . ARG B 1 260 ? 27.320 4.307   -3.756  1.00 73.13  ? 178 ARG B O     1 
ATOM   3103 C  CB    . ARG B 1 260 ? 29.833 6.329   -3.778  1.00 65.08  ? 178 ARG B CB    1 
ATOM   3104 C  CG    . ARG B 1 260 ? 30.300 7.059   -2.533  1.00 73.53  ? 178 ARG B CG    1 
ATOM   3105 C  CD    . ARG B 1 260 ? 30.053 8.534   -2.672  1.00 83.97  ? 178 ARG B CD    1 
ATOM   3106 N  NE    . ARG B 1 260 ? 31.163 9.186   -3.369  1.00 91.39  ? 178 ARG B NE    1 
ATOM   3107 C  CZ    . ARG B 1 260 ? 32.278 9.611   -2.751  1.00 93.30  ? 178 ARG B CZ    1 
ATOM   3108 N  NH1   . ARG B 1 260 ? 32.486 9.391   -1.440  1.00 69.39  ? 178 ARG B NH1   1 
ATOM   3109 N  NH2   . ARG B 1 260 ? 33.172 10.275  -3.475  1.00 81.03  ? 178 ARG B NH2   1 
ATOM   3110 N  N     . ARG B 1 261 ? 28.540 4.319   -5.651  1.00 62.68  ? 179 ARG B N     1 
ATOM   3111 C  CA    . ARG B 1 261 ? 27.423 4.077   -6.538  1.00 72.90  ? 179 ARG B CA    1 
ATOM   3112 C  C     . ARG B 1 261 ? 27.103 2.584   -6.674  1.00 72.86  ? 179 ARG B C     1 
ATOM   3113 O  O     . ARG B 1 261 ? 26.003 2.240   -7.080  1.00 70.59  ? 179 ARG B O     1 
ATOM   3114 C  CB    . ARG B 1 261 ? 27.777 4.720   -7.882  1.00 74.85  ? 179 ARG B CB    1 
ATOM   3115 C  CG    . ARG B 1 261 ? 27.858 6.235   -7.769  1.00 77.70  ? 179 ARG B CG    1 
ATOM   3116 C  CD    . ARG B 1 261 ? 28.397 6.843   -9.049  1.00 90.92  ? 179 ARG B CD    1 
ATOM   3117 N  NE    . ARG B 1 261 ? 27.449 6.840   -10.172 1.00 85.04  ? 179 ARG B NE    1 
ATOM   3118 C  CZ    . ARG B 1 261 ? 27.254 7.872   -10.989 1.00 79.89  ? 179 ARG B CZ    1 
ATOM   3119 N  NH1   . ARG B 1 261 ? 27.963 8.993   -10.882 1.00 82.35  ? 179 ARG B NH1   1 
ATOM   3120 N  NH2   . ARG B 1 261 ? 26.363 7.763   -11.945 1.00 79.36  ? 179 ARG B NH2   1 
ATOM   3121 N  N     . ASP B 1 262 ? 28.057 1.695   -6.375  1.00 73.67  ? 180 ASP B N     1 
ATOM   3122 C  CA    . ASP B 1 262 ? 27.825 0.263   -6.500  1.00 71.01  ? 180 ASP B CA    1 
ATOM   3123 C  C     . ASP B 1 262 ? 27.247 -0.286  -5.192  1.00 72.23  ? 180 ASP B C     1 
ATOM   3124 O  O     . ASP B 1 262 ? 26.591 -1.321  -5.204  1.00 68.25  ? 180 ASP B O     1 
ATOM   3125 C  CB    . ASP B 1 262 ? 29.080 -0.490  -6.932  1.00 69.26  ? 180 ASP B CB    1 
ATOM   3126 C  CG    . ASP B 1 262 ? 29.434 -0.465  -8.416  1.00 73.42  ? 180 ASP B CG    1 
ATOM   3127 O  OD1   . ASP B 1 262 ? 28.705 0.208   -9.177  1.00 68.44  ? 180 ASP B OD1   1 
ATOM   3128 O  OD2   . ASP B 1 262 ? 30.454 -1.114  -8.801  1.00 70.96  ? 180 ASP B OD2   1 
ATOM   3129 N  N     . TYR B 1 263 ? 27.471 0.416   -4.072  1.00 67.98  ? 181 TYR B N     1 
ATOM   3130 C  CA    . TYR B 1 263 ? 27.194 -0.138  -2.754  1.00 72.29  ? 181 TYR B CA    1 
ATOM   3131 C  C     . TYR B 1 263 ? 25.690 -0.313  -2.532  1.00 82.33  ? 181 TYR B C     1 
ATOM   3132 O  O     . TYR B 1 263 ? 25.293 -1.206  -1.782  1.00 79.78  ? 181 TYR B O     1 
ATOM   3133 C  CB    . TYR B 1 263 ? 27.754 0.717   -1.612  1.00 63.99  ? 181 TYR B CB    1 
ATOM   3134 C  CG    . TYR B 1 263 ? 28.034 -0.115  -0.372  1.00 68.38  ? 181 TYR B CG    1 
ATOM   3135 C  CD1   . TYR B 1 263 ? 29.224 -0.820  -0.248  1.00 63.01  ? 181 TYR B CD1   1 
ATOM   3136 C  CD2   . TYR B 1 263 ? 27.092 -0.247  0.644   1.00 67.01  ? 181 TYR B CD2   1 
ATOM   3137 C  CE1   . TYR B 1 263 ? 29.480 -1.604  0.865   1.00 65.24  ? 181 TYR B CE1   1 
ATOM   3138 C  CE2   . TYR B 1 263 ? 27.344 -1.014  1.772   1.00 62.14  ? 181 TYR B CE2   1 
ATOM   3139 C  CZ    . TYR B 1 263 ? 28.539 -1.704  1.877   1.00 65.07  ? 181 TYR B CZ    1 
ATOM   3140 O  OH    . TYR B 1 263 ? 28.799 -2.493  2.963   1.00 59.17  ? 181 TYR B OH    1 
ATOM   3141 N  N     . GLY B 1 264 ? 24.878 0.547   -3.169  1.00 81.04  ? 182 GLY B N     1 
ATOM   3142 C  CA    . GLY B 1 264 ? 23.432 0.536   -3.018  1.00 78.07  ? 182 GLY B CA    1 
ATOM   3143 C  C     . GLY B 1 264 ? 22.830 -0.822  -3.373  1.00 76.35  ? 182 GLY B C     1 
ATOM   3144 O  O     . GLY B 1 264 ? 22.046 -1.384  -2.606  1.00 74.30  ? 182 GLY B O     1 
ATOM   3145 N  N     . ASP B 1 265 ? 23.224 -1.343  -4.539  1.00 69.39  ? 183 ASP B N     1 
ATOM   3146 C  CA    . ASP B 1 265 ? 22.714 -2.609  -5.046  1.00 67.02  ? 183 ASP B CA    1 
ATOM   3147 C  C     . ASP B 1 265 ? 23.251 -3.792  -4.235  1.00 71.76  ? 183 ASP B C     1 
ATOM   3148 O  O     . ASP B 1 265 ? 22.531 -4.755  -3.952  1.00 76.86  ? 183 ASP B O     1 
ATOM   3149 C  CB    . ASP B 1 265 ? 23.004 -2.759  -6.529  1.00 62.09  ? 183 ASP B CB    1 
ATOM   3150 C  CG    . ASP B 1 265 ? 22.348 -3.972  -7.164  1.00 79.14  ? 183 ASP B CG    1 
ATOM   3151 O  OD1   . ASP B 1 265 ? 22.804 -5.104  -6.875  1.00 81.61  ? 183 ASP B OD1   1 
ATOM   3152 O  OD2   . ASP B 1 265 ? 21.352 -3.772  -7.893  1.00 93.67  ? 183 ASP B OD2   1 
ATOM   3153 N  N     . PHE B 1 266 ? 24.534 -3.728  -3.875  1.00 69.16  ? 184 PHE B N     1 
ATOM   3154 C  CA    . PHE B 1 266 ? 25.150 -4.804  -3.122  1.00 67.88  ? 184 PHE B CA    1 
ATOM   3155 C  C     . PHE B 1 266 ? 24.432 -4.899  -1.771  1.00 64.65  ? 184 PHE B C     1 
ATOM   3156 O  O     . PHE B 1 266 ? 24.195 -5.995  -1.292  1.00 75.10  ? 184 PHE B O     1 
ATOM   3157 C  CB    . PHE B 1 266 ? 26.685 -4.644  -3.075  1.00 56.63  ? 184 PHE B CB    1 
ATOM   3158 C  CG    . PHE B 1 266 ? 27.318 -5.314  -1.866  1.00 43.50  ? 184 PHE B CG    1 
ATOM   3159 C  CD1   . PHE B 1 266 ? 27.577 -6.669  -1.860  1.00 47.80  ? 184 PHE B CD1   1 
ATOM   3160 C  CD2   . PHE B 1 266 ? 27.553 -4.601  -0.691  1.00 46.63  ? 184 PHE B CD2   1 
ATOM   3161 C  CE1   . PHE B 1 266 ? 28.069 -7.300  -0.717  1.00 48.52  ? 184 PHE B CE1   1 
ATOM   3162 C  CE2   . PHE B 1 266 ? 28.076 -5.228  0.432   1.00 46.77  ? 184 PHE B CE2   1 
ATOM   3163 C  CZ    . PHE B 1 266 ? 28.315 -6.581  0.423   1.00 43.15  ? 184 PHE B CZ    1 
ATOM   3164 N  N     . TYR B 1 267 ? 24.081 -3.768  -1.151  1.00 67.84  ? 185 TYR B N     1 
ATOM   3165 C  CA    . TYR B 1 267 ? 23.473 -3.780  0.174   1.00 70.19  ? 185 TYR B CA    1 
ATOM   3166 C  C     . TYR B 1 267 ? 22.036 -4.297  0.103   1.00 69.07  ? 185 TYR B C     1 
ATOM   3167 O  O     . TYR B 1 267 ? 21.640 -5.145  0.907   1.00 57.75  ? 185 TYR B O     1 
ATOM   3168 C  CB    . TYR B 1 267 ? 23.468 -2.371  0.755   1.00 65.34  ? 185 TYR B CB    1 
ATOM   3169 C  CG    . TYR B 1 267 ? 22.968 -2.278  2.183   1.00 64.69  ? 185 TYR B CG    1 
ATOM   3170 C  CD1   . TYR B 1 267 ? 23.688 -2.850  3.217   1.00 58.98  ? 185 TYR B CD1   1 
ATOM   3171 C  CD2   . TYR B 1 267 ? 21.810 -1.564  2.506   1.00 73.15  ? 185 TYR B CD2   1 
ATOM   3172 C  CE1   . TYR B 1 267 ? 23.269 -2.716  4.536   1.00 75.22  ? 185 TYR B CE1   1 
ATOM   3173 C  CE2   . TYR B 1 267 ? 21.371 -1.439  3.821   1.00 68.94  ? 185 TYR B CE2   1 
ATOM   3174 C  CZ    . TYR B 1 267 ? 22.110 -2.013  4.841   1.00 71.62  ? 185 TYR B CZ    1 
ATOM   3175 O  OH    . TYR B 1 267 ? 21.711 -1.930  6.142   1.00 66.28  ? 185 TYR B OH    1 
ATOM   3176 N  N     . HIS B 1 268 ? 21.282 -3.759  -0.865  1.00 68.02  ? 186 HIS B N     1 
ATOM   3177 C  CA    . HIS B 1 268 ? 19.938 -4.211  -1.179  1.00 72.32  ? 186 HIS B CA    1 
ATOM   3178 C  C     . HIS B 1 268 ? 20.000 -5.739  -1.233  1.00 78.08  ? 186 HIS B C     1 
ATOM   3179 O  O     . HIS B 1 268 ? 19.326 -6.408  -0.443  1.00 78.05  ? 186 HIS B O     1 
ATOM   3180 C  CB    . HIS B 1 268 ? 19.428 -3.459  -2.426  1.00 85.15  ? 186 HIS B CB    1 
ATOM   3181 C  CG    . HIS B 1 268 ? 18.087 -3.851  -3.008  1.00 112.50 ? 186 HIS B CG    1 
ATOM   3182 N  ND1   . HIS B 1 268 ? 16.863 -3.457  -2.492  1.00 112.89 ? 186 HIS B ND1   1 
ATOM   3183 C  CD2   . HIS B 1 268 ? 17.796 -4.589  -4.110  1.00 109.30 ? 186 HIS B CD2   1 
ATOM   3184 C  CE1   . HIS B 1 268 ? 15.882 -3.960  -3.240  1.00 104.55 ? 186 HIS B CE1   1 
ATOM   3185 N  NE2   . HIS B 1 268 ? 16.425 -4.647  -4.228  1.00 106.16 ? 186 HIS B NE2   1 
ATOM   3186 N  N     . THR B 1 269 ? 20.882 -6.274  -2.099  1.00 70.21  ? 187 THR B N     1 
ATOM   3187 C  CA    . THR B 1 269 ? 20.950 -7.707  -2.357  1.00 63.86  ? 187 THR B CA    1 
ATOM   3188 C  C     . THR B 1 269 ? 21.283 -8.457  -1.052  1.00 68.66  ? 187 THR B C     1 
ATOM   3189 O  O     . THR B 1 269 ? 20.727 -9.521  -0.768  1.00 66.94  ? 187 THR B O     1 
ATOM   3190 C  CB    . THR B 1 269 ? 21.934 -7.970  -3.507  1.00 63.09  ? 187 THR B CB    1 
ATOM   3191 O  OG1   . THR B 1 269 ? 21.645 -7.060  -4.558  1.00 62.23  ? 187 THR B OG1   1 
ATOM   3192 C  CG2   . THR B 1 269 ? 21.808 -9.338  -4.158  1.00 65.39  ? 187 THR B CG2   1 
ATOM   3193 N  N     . VAL B 1 270 ? 22.152 -7.891  -0.209  1.00 65.87  ? 188 VAL B N     1 
ATOM   3194 C  CA    . VAL B 1 270 ? 22.544 -8.566  1.019   1.00 70.65  ? 188 VAL B CA    1 
ATOM   3195 C  C     . VAL B 1 270 ? 21.309 -8.825  1.886   1.00 76.06  ? 188 VAL B C     1 
ATOM   3196 O  O     . VAL B 1 270 ? 21.065 -9.966  2.309   1.00 59.05  ? 188 VAL B O     1 
ATOM   3197 C  CB    . VAL B 1 270 ? 23.621 -7.741  1.749   1.00 67.10  ? 188 VAL B CB    1 
ATOM   3198 C  CG1   . VAL B 1 270 ? 23.632 -7.949  3.261   1.00 66.09  ? 188 VAL B CG1   1 
ATOM   3199 C  CG2   . VAL B 1 270 ? 24.996 -8.022  1.166   1.00 72.12  ? 188 VAL B CG2   1 
ATOM   3200 N  N     . ARG B 1 271 ? 20.540 -7.741  2.089   1.00 82.10  ? 189 ARG B N     1 
ATOM   3201 C  CA    . ARG B 1 271 ? 19.404 -7.679  2.999   1.00 76.46  ? 189 ARG B CA    1 
ATOM   3202 C  C     . ARG B 1 271 ? 18.241 -8.521  2.494   1.00 75.79  ? 189 ARG B C     1 
ATOM   3203 O  O     . ARG B 1 271 ? 17.639 -9.258  3.264   1.00 75.88  ? 189 ARG B O     1 
ATOM   3204 C  CB    . ARG B 1 271 ? 18.896 -6.242  3.149   1.00 67.98  ? 189 ARG B CB    1 
ATOM   3205 C  CG    . ARG B 1 271 ? 19.800 -5.376  4.015   1.00 68.50  ? 189 ARG B CG    1 
ATOM   3206 C  CD    . ARG B 1 271 ? 20.165 -6.064  5.316   1.00 63.76  ? 189 ARG B CD    1 
ATOM   3207 N  NE    . ARG B 1 271 ? 20.911 -5.109  6.137   1.00 66.65  ? 189 ARG B NE    1 
ATOM   3208 C  CZ    . ARG B 1 271 ? 21.947 -5.359  6.930   1.00 74.20  ? 189 ARG B CZ    1 
ATOM   3209 N  NH1   . ARG B 1 271 ? 22.428 -6.584  7.052   1.00 74.54  ? 189 ARG B NH1   1 
ATOM   3210 N  NH2   . ARG B 1 271 ? 22.502 -4.360  7.602   1.00 76.07  ? 189 ARG B NH2   1 
ATOM   3211 N  N     . GLN B 1 272 ? 17.938 -8.426  1.202   1.00 68.45  ? 190 GLN B N     1 
ATOM   3212 C  CA    . GLN B 1 272 ? 16.890 -9.252  0.646   1.00 73.08  ? 190 GLN B CA    1 
ATOM   3213 C  C     . GLN B 1 272 ? 17.331 -10.716 0.578   1.00 76.78  ? 190 GLN B C     1 
ATOM   3214 O  O     . GLN B 1 272 ? 16.590 -11.505 -0.001  1.00 84.40  ? 190 GLN B O     1 
ATOM   3215 C  CB    . GLN B 1 272 ? 16.454 -8.724  -0.723  1.00 84.71  ? 190 GLN B CB    1 
ATOM   3216 C  CG    . GLN B 1 272 ? 17.281 -9.252  -1.887  1.00 92.60  ? 190 GLN B CG    1 
ATOM   3217 C  CD    . GLN B 1 272 ? 16.819 -8.743  -3.232  1.00 105.54 ? 190 GLN B CD    1 
ATOM   3218 O  OE1   . GLN B 1 272 ? 15.966 -7.855  -3.323  1.00 111.13 ? 190 GLN B OE1   1 
ATOM   3219 N  NE2   . GLN B 1 272 ? 17.399 -9.298  -4.289  1.00 113.97 ? 190 GLN B NE2   1 
ATOM   3220 N  N     . HIS B 1 273 ? 18.534 -11.073 1.090   1.00 73.90  ? 191 HIS B N     1 
ATOM   3221 C  CA    . HIS B 1 273 ? 18.897 -12.469 1.347   1.00 62.47  ? 191 HIS B CA    1 
ATOM   3222 C  C     . HIS B 1 273 ? 19.167 -12.684 2.832   1.00 64.19  ? 191 HIS B C     1 
ATOM   3223 O  O     . HIS B 1 273 ? 19.600 -13.769 3.241   1.00 60.27  ? 191 HIS B O     1 
ATOM   3224 C  CB    . HIS B 1 273 ? 20.090 -12.921 0.504   1.00 56.56  ? 191 HIS B CB    1 
ATOM   3225 C  CG    . HIS B 1 273 ? 19.793 -13.116 -0.944  1.00 55.98  ? 191 HIS B CG    1 
ATOM   3226 N  ND1   . HIS B 1 273 ? 19.776 -14.376 -1.518  1.00 61.85  ? 191 HIS B ND1   1 
ATOM   3227 C  CD2   . HIS B 1 273 ? 19.555 -12.238 -1.947  1.00 54.68  ? 191 HIS B CD2   1 
ATOM   3228 C  CE1   . HIS B 1 273 ? 19.516 -14.265 -2.827  1.00 59.32  ? 191 HIS B CE1   1 
ATOM   3229 N  NE2   . HIS B 1 273 ? 19.369 -12.971 -3.110  1.00 62.67  ? 191 HIS B NE2   1 
ATOM   3230 N  N     . GLY B 1 274 ? 18.866 -11.632 3.608   1.00 64.60  ? 192 GLY B N     1 
ATOM   3231 C  CA    . GLY B 1 274 ? 18.963 -11.607 5.058   1.00 65.05  ? 192 GLY B CA    1 
ATOM   3232 C  C     . GLY B 1 274 ? 20.398 -11.764 5.547   1.00 78.81  ? 192 GLY B C     1 
ATOM   3233 O  O     . GLY B 1 274 ? 20.607 -12.164 6.692   1.00 69.76  ? 192 GLY B O     1 
ATOM   3234 N  N     . ALA B 1 275 ? 21.382 -11.439 4.688   1.00 79.87  ? 193 ALA B N     1 
ATOM   3235 C  CA    . ALA B 1 275 ? 22.782 -11.636 5.043   1.00 76.23  ? 193 ALA B CA    1 
ATOM   3236 C  C     . ALA B 1 275 ? 23.239 -10.519 5.978   1.00 59.15  ? 193 ALA B C     1 
ATOM   3237 O  O     . ALA B 1 275 ? 22.635 -9.457  6.024   1.00 70.63  ? 193 ALA B O     1 
ATOM   3238 C  CB    . ALA B 1 275 ? 23.626 -11.714 3.792   1.00 76.52  ? 193 ALA B CB    1 
ATOM   3239 N  N     . ARG B 1 276 ? 24.272 -10.788 6.765   1.00 64.55  ? 194 ARG B N     1 
ATOM   3240 C  CA    . ARG B 1 276 ? 24.938 -9.750  7.550   1.00 79.42  ? 194 ARG B CA    1 
ATOM   3241 C  C     . ARG B 1 276 ? 26.271 -9.366  6.875   1.00 68.93  ? 194 ARG B C     1 
ATOM   3242 O  O     . ARG B 1 276 ? 26.882 -10.188 6.193   1.00 64.93  ? 194 ARG B O     1 
ATOM   3243 C  CB    . ARG B 1 276 ? 25.079 -10.237 9.006   1.00 81.04  ? 194 ARG B CB    1 
ATOM   3244 C  CG    . ARG B 1 276 ? 23.784 -10.460 9.782   1.00 83.49  ? 194 ARG B CG    1 
ATOM   3245 C  CD    . ARG B 1 276 ? 23.271 -9.182  10.434  1.00 92.03  ? 194 ARG B CD    1 
ATOM   3246 N  NE    . ARG B 1 276 ? 21.924 -9.253  11.016  1.00 100.44 ? 194 ARG B NE    1 
ATOM   3247 C  CZ    . ARG B 1 276 ? 21.235 -8.188  11.441  1.00 97.04  ? 194 ARG B CZ    1 
ATOM   3248 N  NH1   . ARG B 1 276 ? 21.773 -6.983  11.411  1.00 87.88  ? 194 ARG B NH1   1 
ATOM   3249 N  NH2   . ARG B 1 276 ? 20.009 -8.322  11.906  1.00 94.36  ? 194 ARG B NH2   1 
ATOM   3250 N  N     . ILE B 1 277 ? 26.722 -8.113  7.070   1.00 64.96  ? 195 ILE B N     1 
ATOM   3251 C  CA    . ILE B 1 277 ? 27.978 -7.606  6.527   1.00 58.27  ? 195 ILE B CA    1 
ATOM   3252 C  C     . ILE B 1 277 ? 28.965 -7.300  7.647   1.00 61.95  ? 195 ILE B C     1 
ATOM   3253 O  O     . ILE B 1 277 ? 28.660 -6.472  8.507   1.00 63.66  ? 195 ILE B O     1 
ATOM   3254 C  CB    . ILE B 1 277 ? 27.722 -6.345  5.702   1.00 55.22  ? 195 ILE B CB    1 
ATOM   3255 C  CG1   . ILE B 1 277 ? 26.939 -6.685  4.450   1.00 58.45  ? 195 ILE B CG1   1 
ATOM   3256 C  CG2   . ILE B 1 277 ? 29.038 -5.652  5.379   1.00 61.69  ? 195 ILE B CG2   1 
ATOM   3257 C  CD1   . ILE B 1 277 ? 26.292 -5.488  3.788   1.00 54.48  ? 195 ILE B CD1   1 
ATOM   3258 N  N     . VAL B 1 278 ? 30.150 -7.941  7.604   1.00 61.38  ? 196 VAL B N     1 
ATOM   3259 C  CA    . VAL B 1 278 ? 31.242 -7.623  8.520   1.00 57.15  ? 196 VAL B CA    1 
ATOM   3260 C  C     . VAL B 1 278 ? 32.448 -7.144  7.714   1.00 58.78  ? 196 VAL B C     1 
ATOM   3261 O  O     . VAL B 1 278 ? 32.874 -7.809  6.764   1.00 52.52  ? 196 VAL B O     1 
ATOM   3262 C  CB    . VAL B 1 278 ? 31.644 -8.801  9.417   1.00 57.74  ? 196 VAL B CB    1 
ATOM   3263 C  CG1   . VAL B 1 278 ? 32.862 -8.471  10.266  1.00 57.16  ? 196 VAL B CG1   1 
ATOM   3264 C  CG2   . VAL B 1 278 ? 30.485 -9.269  10.292  1.00 64.54  ? 196 VAL B CG2   1 
ATOM   3265 N  N     . ILE B 1 279 ? 32.982 -5.989  8.136   1.00 51.78  ? 197 ILE B N     1 
ATOM   3266 C  CA    . ILE B 1 279 ? 34.114 -5.331  7.507   1.00 50.28  ? 197 ILE B CA    1 
ATOM   3267 C  C     . ILE B 1 279 ? 35.251 -5.335  8.520   1.00 52.61  ? 197 ILE B C     1 
ATOM   3268 O  O     . ILE B 1 279 ? 34.992 -5.352  9.726   1.00 47.56  ? 197 ILE B O     1 
ATOM   3269 C  CB    . ILE B 1 279 ? 33.785 -3.884  7.059   1.00 47.40  ? 197 ILE B CB    1 
ATOM   3270 C  CG1   . ILE B 1 279 ? 33.394 -2.993  8.228   1.00 51.65  ? 197 ILE B CG1   1 
ATOM   3271 C  CG2   . ILE B 1 279 ? 32.729 -3.815  5.955   1.00 48.99  ? 197 ILE B CG2   1 
ATOM   3272 C  CD1   . ILE B 1 279 ? 33.330 -1.524  7.878   1.00 54.22  ? 197 ILE B CD1   1 
ATOM   3273 N  N     . GLY B 1 280 ? 36.493 -5.275  8.006   1.00 63.02  ? 198 GLY B N     1 
ATOM   3274 C  CA    . GLY B 1 280 ? 37.695 -5.096  8.816   1.00 64.20  ? 198 GLY B CA    1 
ATOM   3275 C  C     . GLY B 1 280 ? 38.909 -4.779  7.941   1.00 62.56  ? 198 GLY B C     1 
ATOM   3276 O  O     . GLY B 1 280 ? 38.814 -4.885  6.707   1.00 51.45  ? 198 GLY B O     1 
ATOM   3277 N  N     . GLY B 1 281 ? 40.018 -4.379  8.602   1.00 55.31  ? 199 GLY B N     1 
ATOM   3278 C  CA    . GLY B 1 281 ? 41.236 -3.921  7.933   1.00 54.16  ? 199 GLY B CA    1 
ATOM   3279 C  C     . GLY B 1 281 ? 41.416 -2.395  7.925   1.00 50.01  ? 199 GLY B C     1 
ATOM   3280 O  O     . GLY B 1 281 ? 40.468 -1.631  8.057   1.00 54.19  ? 199 GLY B O     1 
ATOM   3281 N  N     . ALA B 1 282 ? 42.641 -1.962  7.622   1.00 56.19  ? 200 ALA B N     1 
ATOM   3282 C  CA    . ALA B 1 282 ? 43.097 -0.584  7.778   1.00 52.88  ? 200 ALA B CA    1 
ATOM   3283 C  C     . ALA B 1 282 ? 42.340 0.411   6.897   1.00 53.33  ? 200 ALA B C     1 
ATOM   3284 O  O     . ALA B 1 282 ? 42.273 1.590   7.229   1.00 52.56  ? 200 ALA B O     1 
ATOM   3285 C  CB    . ALA B 1 282 ? 44.588 -0.494  7.506   1.00 46.93  ? 200 ALA B CB    1 
ATOM   3286 N  N     . ALA B 1 283 ? 41.770 -0.036  5.776   1.00 58.82  ? 201 ALA B N     1 
ATOM   3287 C  CA    . ALA B 1 283 ? 41.119 0.889   4.859   1.00 55.27  ? 201 ALA B CA    1 
ATOM   3288 C  C     . ALA B 1 283 ? 39.939 1.607   5.529   1.00 58.68  ? 201 ALA B C     1 
ATOM   3289 O  O     . ALA B 1 283 ? 39.585 2.724   5.136   1.00 59.40  ? 201 ALA B O     1 
ATOM   3290 C  CB    . ALA B 1 283 ? 40.702 0.169   3.589   1.00 45.94  ? 201 ALA B CB    1 
ATOM   3291 N  N     . PHE B 1 284 ? 39.339 0.969   6.542   1.00 59.68  ? 202 PHE B N     1 
ATOM   3292 C  CA    . PHE B 1 284 ? 38.165 1.513   7.214   1.00 63.56  ? 202 PHE B CA    1 
ATOM   3293 C  C     . PHE B 1 284 ? 38.546 2.512   8.310   1.00 61.31  ? 202 PHE B C     1 
ATOM   3294 O  O     . PHE B 1 284 ? 37.662 3.121   8.886   1.00 69.79  ? 202 PHE B O     1 
ATOM   3295 C  CB    . PHE B 1 284 ? 37.325 0.352   7.756   1.00 61.77  ? 202 PHE B CB    1 
ATOM   3296 C  CG    . PHE B 1 284 ? 36.828 -0.554  6.635   1.00 57.44  ? 202 PHE B CG    1 
ATOM   3297 C  CD1   . PHE B 1 284 ? 36.122 -0.025  5.560   1.00 51.91  ? 202 PHE B CD1   1 
ATOM   3298 C  CD2   . PHE B 1 284 ? 37.146 -1.916  6.617   1.00 58.77  ? 202 PHE B CD2   1 
ATOM   3299 C  CE1   . PHE B 1 284 ? 35.693 -0.840  4.524   1.00 55.15  ? 202 PHE B CE1   1 
ATOM   3300 C  CE2   . PHE B 1 284 ? 36.738 -2.727  5.567   1.00 52.31  ? 202 PHE B CE2   1 
ATOM   3301 C  CZ    . PHE B 1 284 ? 36.007 -2.192  4.524   1.00 52.15  ? 202 PHE B CZ    1 
ATOM   3302 N  N     . ALA B 1 285 ? 39.839 2.720   8.572   1.00 51.96  ? 203 ALA B N     1 
ATOM   3303 C  CA    . ALA B 1 285 ? 40.267 3.860   9.366   1.00 55.98  ? 203 ALA B CA    1 
ATOM   3304 C  C     . ALA B 1 285 ? 39.959 5.183   8.653   1.00 60.55  ? 203 ALA B C     1 
ATOM   3305 O  O     . ALA B 1 285 ? 39.985 6.235   9.274   1.00 73.03  ? 203 ALA B O     1 
ATOM   3306 C  CB    . ALA B 1 285 ? 41.742 3.744   9.695   1.00 52.98  ? 203 ALA B CB    1 
ATOM   3307 N  N     . ASP B 1 286 ? 39.691 5.152   7.348   1.00 58.95  ? 204 ASP B N     1 
ATOM   3308 C  CA    . ASP B 1 286 ? 39.336 6.340   6.593   1.00 61.08  ? 204 ASP B CA    1 
ATOM   3309 C  C     . ASP B 1 286 ? 37.825 6.527   6.649   1.00 76.61  ? 204 ASP B C     1 
ATOM   3310 O  O     . ASP B 1 286 ? 37.064 5.677   6.172   1.00 68.51  ? 204 ASP B O     1 
ATOM   3311 C  CB    . ASP B 1 286 ? 39.734 6.198   5.135   1.00 66.28  ? 204 ASP B CB    1 
ATOM   3312 C  CG    . ASP B 1 286 ? 39.216 7.283   4.206   1.00 70.19  ? 204 ASP B CG    1 
ATOM   3313 O  OD1   . ASP B 1 286 ? 37.993 7.549   4.200   1.00 70.65  ? 204 ASP B OD1   1 
ATOM   3314 O  OD2   . ASP B 1 286 ? 40.047 7.839   3.481   1.00 67.99  ? 204 ASP B OD2   1 
ATOM   3315 N  N     . PRO B 1 287 ? 37.341 7.690   7.138   1.00 84.78  ? 205 PRO B N     1 
ATOM   3316 C  CA    . PRO B 1 287 ? 35.925 7.823   7.489   1.00 72.03  ? 205 PRO B CA    1 
ATOM   3317 C  C     . PRO B 1 287 ? 35.044 7.782   6.244   1.00 58.98  ? 205 PRO B C     1 
ATOM   3318 O  O     . PRO B 1 287 ? 33.923 7.317   6.325   1.00 57.11  ? 205 PRO B O     1 
ATOM   3319 C  CB    . PRO B 1 287 ? 35.871 9.166   8.242   1.00 72.47  ? 205 PRO B CB    1 
ATOM   3320 C  CG    . PRO B 1 287 ? 37.009 9.967   7.620   1.00 79.72  ? 205 PRO B CG    1 
ATOM   3321 C  CD    . PRO B 1 287 ? 38.096 8.949   7.274   1.00 77.35  ? 205 PRO B CD    1 
ATOM   3322 N  N     . GLN B 1 288 ? 35.557 8.253   5.095   1.00 63.32  ? 206 GLN B N     1 
ATOM   3323 C  CA    . GLN B 1 288 ? 34.806 8.248   3.845   1.00 58.41  ? 206 GLN B CA    1 
ATOM   3324 C  C     . GLN B 1 288 ? 34.608 6.823   3.337   1.00 64.64  ? 206 GLN B C     1 
ATOM   3325 O  O     . GLN B 1 288 ? 33.553 6.499   2.788   1.00 68.37  ? 206 GLN B O     1 
ATOM   3326 C  CB    . GLN B 1 288 ? 35.443 9.084   2.739   1.00 61.29  ? 206 GLN B CB    1 
ATOM   3327 C  CG    . GLN B 1 288 ? 34.667 10.342  2.383   1.00 70.46  ? 206 GLN B CG    1 
ATOM   3328 C  CD    . GLN B 1 288 ? 34.447 11.271  3.557   1.00 89.81  ? 206 GLN B CD    1 
ATOM   3329 O  OE1   . GLN B 1 288 ? 35.396 11.707  4.226   1.00 95.97  ? 206 GLN B OE1   1 
ATOM   3330 N  NE2   . GLN B 1 288 ? 33.181 11.576  3.818   1.00 89.59  ? 206 GLN B NE2   1 
ATOM   3331 N  N     . VAL B 1 289 ? 35.622 5.971   3.517   1.00 69.60  ? 207 VAL B N     1 
ATOM   3332 C  CA    . VAL B 1 289 ? 35.490 4.572   3.132   1.00 65.88  ? 207 VAL B CA    1 
ATOM   3333 C  C     . VAL B 1 289 ? 34.472 3.888   4.060   1.00 57.17  ? 207 VAL B C     1 
ATOM   3334 O  O     . VAL B 1 289 ? 33.503 3.307   3.561   1.00 57.57  ? 207 VAL B O     1 
ATOM   3335 C  CB    . VAL B 1 289 ? 36.877 3.887   3.100   1.00 69.26  ? 207 VAL B CB    1 
ATOM   3336 C  CG1   . VAL B 1 289 ? 36.812 2.389   2.836   1.00 61.74  ? 207 VAL B CG1   1 
ATOM   3337 C  CG2   . VAL B 1 289 ? 37.786 4.533   2.067   1.00 68.03  ? 207 VAL B CG2   1 
ATOM   3338 N  N     . ARG B 1 290 ? 34.667 3.987   5.390   1.00 47.87  ? 208 ARG B N     1 
ATOM   3339 C  CA    . ARG B 1 290 ? 33.778 3.369   6.372   1.00 55.18  ? 208 ARG B CA    1 
ATOM   3340 C  C     . ARG B 1 290 ? 32.321 3.794   6.152   1.00 59.63  ? 208 ARG B C     1 
ATOM   3341 O  O     . ARG B 1 290 ? 31.400 2.986   6.281   1.00 75.27  ? 208 ARG B O     1 
ATOM   3342 C  CB    . ARG B 1 290 ? 34.270 3.660   7.796   1.00 59.43  ? 208 ARG B CB    1 
ATOM   3343 C  CG    . ARG B 1 290 ? 33.449 3.183   8.991   1.00 63.38  ? 208 ARG B CG    1 
ATOM   3344 C  CD    . ARG B 1 290 ? 34.100 3.526   10.373  1.00 69.28  ? 208 ARG B CD    1 
ATOM   3345 N  NE    . ARG B 1 290 ? 34.252 4.970   10.629  1.00 84.39  ? 208 ARG B NE    1 
ATOM   3346 C  CZ    . ARG B 1 290 ? 35.395 5.691   10.714  1.00 93.26  ? 208 ARG B CZ    1 
ATOM   3347 N  NH1   . ARG B 1 290 ? 36.596 5.141   10.730  1.00 86.38  ? 208 ARG B NH1   1 
ATOM   3348 N  NH2   . ARG B 1 290 ? 35.345 7.005   10.793  1.00 101.34 ? 208 ARG B NH2   1 
ATOM   3349 N  N     . GLU B 1 291 ? 32.103 5.061   5.799   1.00 64.33  ? 209 GLU B N     1 
ATOM   3350 C  CA    . GLU B 1 291 ? 30.771 5.575   5.513   1.00 68.33  ? 209 GLU B CA    1 
ATOM   3351 C  C     . GLU B 1 291 ? 30.123 4.845   4.338   1.00 64.08  ? 209 GLU B C     1 
ATOM   3352 O  O     . GLU B 1 291 ? 28.929 4.617   4.345   1.00 74.71  ? 209 GLU B O     1 
ATOM   3353 C  CB    . GLU B 1 291 ? 30.872 7.058   5.171   1.00 78.43  ? 209 GLU B CB    1 
ATOM   3354 C  CG    . GLU B 1 291 ? 29.533 7.774   5.038   1.00 88.90  ? 209 GLU B CG    1 
ATOM   3355 C  CD    . GLU B 1 291 ? 29.776 9.266   4.889   1.00 104.66 ? 209 GLU B CD    1 
ATOM   3356 O  OE1   . GLU B 1 291 ? 30.511 9.886   5.708   1.00 92.46  ? 209 GLU B OE1   1 
ATOM   3357 O  OE2   . GLU B 1 291 ? 29.224 9.803   3.910   1.00 115.98 ? 209 GLU B OE2   1 
ATOM   3358 N  N     . ILE B 1 292 ? 30.876 4.515   3.294   1.00 65.38  ? 210 ILE B N     1 
ATOM   3359 C  CA    . ILE B 1 292 ? 30.273 3.874   2.136   1.00 64.43  ? 210 ILE B CA    1 
ATOM   3360 C  C     . ILE B 1 292 ? 29.915 2.430   2.489   1.00 66.07  ? 210 ILE B C     1 
ATOM   3361 O  O     . ILE B 1 292 ? 28.943 1.877   1.956   1.00 67.72  ? 210 ILE B O     1 
ATOM   3362 C  CB    . ILE B 1 292 ? 31.207 3.950   0.916   1.00 63.05  ? 210 ILE B CB    1 
ATOM   3363 C  CG1   . ILE B 1 292 ? 31.519 5.386   0.526   1.00 62.18  ? 210 ILE B CG1   1 
ATOM   3364 C  CG2   . ILE B 1 292 ? 30.610 3.191   -0.266  1.00 67.04  ? 210 ILE B CG2   1 
ATOM   3365 C  CD1   . ILE B 1 292 ? 32.612 5.513   -0.520  1.00 64.21  ? 210 ILE B CD1   1 
ATOM   3366 N  N     . PHE B 1 293 ? 30.718 1.825   3.380   1.00 64.77  ? 211 PHE B N     1 
ATOM   3367 C  CA    . PHE B 1 293 ? 30.628 0.394   3.642   1.00 73.27  ? 211 PHE B CA    1 
ATOM   3368 C  C     . PHE B 1 293 ? 29.670 0.193   4.819   1.00 75.71  ? 211 PHE B C     1 
ATOM   3369 O  O     . PHE B 1 293 ? 30.077 -0.144  5.943   1.00 61.31  ? 211 PHE B O     1 
ATOM   3370 C  CB    . PHE B 1 293 ? 32.031 -0.228  3.779   1.00 70.08  ? 211 PHE B CB    1 
ATOM   3371 C  CG    . PHE B 1 293 ? 32.761 -0.524  2.464   1.00 65.25  ? 211 PHE B CG    1 
ATOM   3372 C  CD1   . PHE B 1 293 ? 33.427 0.471   1.762   1.00 63.90  ? 211 PHE B CD1   1 
ATOM   3373 C  CD2   . PHE B 1 293 ? 32.816 -1.804  1.937   1.00 62.83  ? 211 PHE B CD2   1 
ATOM   3374 C  CE1   . PHE B 1 293 ? 34.111 0.199   0.588   1.00 56.38  ? 211 PHE B CE1   1 
ATOM   3375 C  CE2   . PHE B 1 293 ? 33.478 -2.060  0.747   1.00 61.63  ? 211 PHE B CE2   1 
ATOM   3376 C  CZ    . PHE B 1 293 ? 34.119 -1.057  0.076   1.00 58.63  ? 211 PHE B CZ    1 
ATOM   3377 N  N     . ILE B 1 294 ? 28.378 0.419   4.529   1.00 68.95  ? 212 ILE B N     1 
ATOM   3378 C  CA    . ILE B 1 294 ? 27.351 0.276   5.543   1.00 70.93  ? 212 ILE B CA    1 
ATOM   3379 C  C     . ILE B 1 294 ? 27.433 -1.173  6.014   1.00 67.62  ? 212 ILE B C     1 
ATOM   3380 O  O     . ILE B 1 294 ? 27.434 -2.094  5.203   1.00 65.38  ? 212 ILE B O     1 
ATOM   3381 C  CB    . ILE B 1 294 ? 25.946 0.634   5.021   1.00 75.86  ? 212 ILE B CB    1 
ATOM   3382 C  CG1   . ILE B 1 294 ? 25.870 1.990   4.318   1.00 76.34  ? 212 ILE B CG1   1 
ATOM   3383 C  CG2   . ILE B 1 294 ? 24.928 0.573   6.162   1.00 81.38  ? 212 ILE B CG2   1 
ATOM   3384 C  CD1   . ILE B 1 294 ? 24.740 2.077   3.297   1.00 75.13  ? 212 ILE B CD1   1 
ATOM   3385 N  N     . HIS B 1 295 ? 27.493 -1.370  7.326   1.00 60.14  ? 213 HIS B N     1 
ATOM   3386 C  CA    . HIS B 1 295 ? 27.837 -2.674  7.852   1.00 65.23  ? 213 HIS B CA    1 
ATOM   3387 C  C     . HIS B 1 295 ? 27.147 -2.967  9.187   1.00 64.29  ? 213 HIS B C     1 
ATOM   3388 O  O     . HIS B 1 295 ? 26.662 -2.078  9.864   1.00 64.34  ? 213 HIS B O     1 
ATOM   3389 C  CB    . HIS B 1 295 ? 29.353 -2.709  8.020   1.00 61.31  ? 213 HIS B CB    1 
ATOM   3390 C  CG    . HIS B 1 295 ? 29.834 -1.649  8.942   1.00 58.49  ? 213 HIS B CG    1 
ATOM   3391 N  ND1   . HIS B 1 295 ? 29.990 -0.344  8.545   1.00 59.22  ? 213 HIS B ND1   1 
ATOM   3392 C  CD2   . HIS B 1 295 ? 30.192 -1.701  10.234  1.00 59.90  ? 213 HIS B CD2   1 
ATOM   3393 C  CE1   . HIS B 1 295 ? 30.443 0.356   9.577   1.00 66.11  ? 213 HIS B CE1   1 
ATOM   3394 N  NE2   . HIS B 1 295 ? 30.583 -0.451  10.614  1.00 57.34  ? 213 HIS B NE2   1 
ATOM   3395 N  N     . ASP B 1 296 ? 27.198 -4.233  9.596   1.00 62.76  ? 214 ASP B N     1 
ATOM   3396 C  CA    . ASP B 1 296 ? 26.591 -4.699  10.829  1.00 60.77  ? 214 ASP B CA    1 
ATOM   3397 C  C     . ASP B 1 296 ? 27.641 -4.784  11.932  1.00 66.47  ? 214 ASP B C     1 
ATOM   3398 O  O     . ASP B 1 296 ? 27.339 -4.528  13.092  1.00 70.29  ? 214 ASP B O     1 
ATOM   3399 C  CB    . ASP B 1 296 ? 25.850 -6.000  10.565  1.00 58.13  ? 214 ASP B CB    1 
ATOM   3400 C  CG    . ASP B 1 296 ? 24.815 -5.886  9.450   1.00 65.04  ? 214 ASP B CG    1 
ATOM   3401 O  OD1   . ASP B 1 296 ? 23.691 -5.392  9.719   1.00 73.94  ? 214 ASP B OD1   1 
ATOM   3402 O  OD2   . ASP B 1 296 ? 25.156 -6.215  8.296   1.00 67.30  ? 214 ASP B OD2   1 
ATOM   3403 N  N     . TYR B 1 297 ? 28.878 -5.147  11.582  1.00 73.94  ? 215 TYR B N     1 
ATOM   3404 C  CA    . TYR B 1 297 ? 29.968 -5.084  12.542  1.00 66.15  ? 215 TYR B CA    1 
ATOM   3405 C  C     . TYR B 1 297 ? 31.260 -4.710  11.820  1.00 64.26  ? 215 TYR B C     1 
ATOM   3406 O  O     . TYR B 1 297 ? 31.524 -5.207  10.731  1.00 74.94  ? 215 TYR B O     1 
ATOM   3407 C  CB    . TYR B 1 297 ? 30.113 -6.406  13.303  1.00 63.44  ? 215 TYR B CB    1 
ATOM   3408 C  CG    . TYR B 1 297 ? 31.103 -6.288  14.452  1.00 62.26  ? 215 TYR B CG    1 
ATOM   3409 C  CD1   . TYR B 1 297 ? 30.828 -5.475  15.541  1.00 62.54  ? 215 TYR B CD1   1 
ATOM   3410 C  CD2   . TYR B 1 297 ? 32.320 -6.958  14.445  1.00 57.29  ? 215 TYR B CD2   1 
ATOM   3411 C  CE1   . TYR B 1 297 ? 31.730 -5.343  16.585  1.00 64.37  ? 215 TYR B CE1   1 
ATOM   3412 C  CE2   . TYR B 1 297 ? 33.232 -6.828  15.483  1.00 52.80  ? 215 TYR B CE2   1 
ATOM   3413 C  CZ    . TYR B 1 297 ? 32.934 -6.017  16.555  1.00 54.03  ? 215 TYR B CZ    1 
ATOM   3414 O  OH    . TYR B 1 297 ? 33.813 -5.852  17.574  1.00 64.46  ? 215 TYR B OH    1 
ATOM   3415 N  N     . GLN B 1 298 ? 32.030 -3.817  12.447  1.00 58.23  ? 216 GLN B N     1 
ATOM   3416 C  CA    . GLN B 1 298 ? 33.401 -3.523  12.084  1.00 57.87  ? 216 GLN B CA    1 
ATOM   3417 C  C     . GLN B 1 298 ? 34.353 -4.099  13.135  1.00 62.25  ? 216 GLN B C     1 
ATOM   3418 O  O     . GLN B 1 298 ? 34.284 -3.722  14.305  1.00 65.77  ? 216 GLN B O     1 
ATOM   3419 C  CB    . GLN B 1 298 ? 33.526 -2.009  11.999  1.00 62.21  ? 216 GLN B CB    1 
ATOM   3420 C  CG    . GLN B 1 298 ? 34.965 -1.500  11.986  1.00 69.86  ? 216 GLN B CG    1 
ATOM   3421 C  CD    . GLN B 1 298 ? 35.050 -0.029  11.655  1.00 68.76  ? 216 GLN B CD    1 
ATOM   3422 O  OE1   . GLN B 1 298 ? 34.054 0.703   11.741  1.00 75.96  ? 216 GLN B OE1   1 
ATOM   3423 N  NE2   . GLN B 1 298 ? 36.228 0.411   11.241  1.00 62.98  ? 216 GLN B NE2   1 
ATOM   3424 N  N     . ALA B 1 299 ? 35.271 -4.977  12.701  1.00 59.48  ? 217 ALA B N     1 
ATOM   3425 C  CA    . ALA B 1 299 ? 36.141 -5.713  13.605  1.00 56.69  ? 217 ALA B CA    1 
ATOM   3426 C  C     . ALA B 1 299 ? 37.516 -5.070  13.659  1.00 57.67  ? 217 ALA B C     1 
ATOM   3427 O  O     . ALA B 1 299 ? 38.077 -4.739  12.618  1.00 73.65  ? 217 ALA B O     1 
ATOM   3428 C  CB    . ALA B 1 299 ? 36.270 -7.144  13.136  1.00 62.56  ? 217 ALA B CB    1 
ATOM   3429 N  N     . ALA B 1 300 ? 38.052 -4.943  14.875  1.00 55.29  ? 218 ALA B N     1 
ATOM   3430 C  CA    . ALA B 1 300 ? 39.390 -4.429  15.111  1.00 56.95  ? 218 ALA B CA    1 
ATOM   3431 C  C     . ALA B 1 300 ? 40.403 -5.546  14.850  1.00 64.84  ? 218 ALA B C     1 
ATOM   3432 O  O     . ALA B 1 300 ? 41.531 -5.312  14.421  1.00 71.28  ? 218 ALA B O     1 
ATOM   3433 C  CB    . ALA B 1 300 ? 39.504 -3.896  16.540  1.00 47.98  ? 218 ALA B CB    1 
ATOM   3434 N  N     . GLY B 1 301 ? 39.994 -6.768  15.180  1.00 61.59  ? 219 GLY B N     1 
ATOM   3435 C  CA    . GLY B 1 301 ? 40.839 -7.932  15.014  1.00 61.54  ? 219 GLY B CA    1 
ATOM   3436 C  C     . GLY B 1 301 ? 39.969 -9.184  14.931  1.00 60.98  ? 219 GLY B C     1 
ATOM   3437 O  O     . GLY B 1 301 ? 38.838 -9.143  14.457  1.00 66.87  ? 219 GLY B O     1 
ATOM   3438 N  N     . LEU B 1 302 ? 40.505 -10.295 15.422  1.00 58.82  ? 220 LEU B N     1 
ATOM   3439 C  CA    . LEU B 1 302 ? 39.822 -11.566 15.307  1.00 62.07  ? 220 LEU B CA    1 
ATOM   3440 C  C     . LEU B 1 302 ? 38.969 -11.809 16.552  1.00 66.25  ? 220 LEU B C     1 
ATOM   3441 O  O     . LEU B 1 302 ? 37.832 -12.269 16.423  1.00 72.01  ? 220 LEU B O     1 
ATOM   3442 C  CB    . LEU B 1 302 ? 40.868 -12.658 15.057  1.00 61.88  ? 220 LEU B CB    1 
ATOM   3443 C  CG    . LEU B 1 302 ? 41.667 -12.533 13.754  1.00 57.04  ? 220 LEU B CG    1 
ATOM   3444 C  CD1   . LEU B 1 302 ? 42.628 -13.684 13.573  1.00 58.19  ? 220 LEU B CD1   1 
ATOM   3445 C  CD2   . LEU B 1 302 ? 40.740 -12.438 12.556  1.00 56.56  ? 220 LEU B CD2   1 
ATOM   3446 N  N     . THR B 1 303 ? 39.507 -11.473 17.740  1.00 62.58  ? 221 THR B N     1 
ATOM   3447 C  CA    . THR B 1 303 ? 38.839 -11.728 19.012  1.00 62.06  ? 221 THR B CA    1 
ATOM   3448 C  C     . THR B 1 303 ? 37.446 -11.086 19.047  1.00 70.38  ? 221 THR B C     1 
ATOM   3449 O  O     . THR B 1 303 ? 36.430 -11.756 19.256  1.00 63.38  ? 221 THR B O     1 
ATOM   3450 C  CB    . THR B 1 303 ? 39.739 -11.220 20.132  1.00 60.61  ? 221 THR B CB    1 
ATOM   3451 O  OG1   . THR B 1 303 ? 40.835 -12.130 20.185  1.00 58.25  ? 221 THR B OG1   1 
ATOM   3452 C  CG2   . THR B 1 303 ? 39.020 -11.212 21.463  1.00 64.43  ? 221 THR B CG2   1 
ATOM   3453 N  N     . ASP B 1 304 ? 37.373 -9.776  18.800  1.00 70.87  ? 222 ASP B N     1 
ATOM   3454 C  CA    . ASP B 1 304 ? 36.081 -9.123  18.849  1.00 68.57  ? 222 ASP B CA    1 
ATOM   3455 C  C     . ASP B 1 304 ? 35.205 -9.654  17.727  1.00 68.74  ? 222 ASP B C     1 
ATOM   3456 O  O     . ASP B 1 304 ? 33.986 -9.662  17.857  1.00 75.05  ? 222 ASP B O     1 
ATOM   3457 C  CB    . ASP B 1 304 ? 36.212 -7.613  18.879  1.00 76.13  ? 222 ASP B CB    1 
ATOM   3458 C  CG    . ASP B 1 304 ? 37.000 -7.041  17.723  1.00 73.89  ? 222 ASP B CG    1 
ATOM   3459 O  OD1   . ASP B 1 304 ? 38.185 -7.408  17.600  1.00 76.47  ? 222 ASP B OD1   1 
ATOM   3460 O  OD2   . ASP B 1 304 ? 36.406 -6.266  16.969  1.00 82.43  ? 222 ASP B OD2   1 
ATOM   3461 N  N     . PHE B 1 305 ? 35.830 -10.101 16.629  1.00 77.26  ? 223 PHE B N     1 
ATOM   3462 C  CA    . PHE B 1 305 ? 35.088 -10.751 15.555  1.00 73.39  ? 223 PHE B CA    1 
ATOM   3463 C  C     . PHE B 1 305 ? 34.331 -11.961 16.106  1.00 64.61  ? 223 PHE B C     1 
ATOM   3464 O  O     . PHE B 1 305 ? 33.152 -12.126 15.822  1.00 51.29  ? 223 PHE B O     1 
ATOM   3465 C  CB    . PHE B 1 305 ? 36.028 -11.142 14.414  1.00 67.99  ? 223 PHE B CB    1 
ATOM   3466 C  CG    . PHE B 1 305 ? 35.380 -11.865 13.238  1.00 57.09  ? 223 PHE B CG    1 
ATOM   3467 C  CD1   . PHE B 1 305 ? 34.288 -11.327 12.576  1.00 50.95  ? 223 PHE B CD1   1 
ATOM   3468 C  CD2   . PHE B 1 305 ? 35.868 -13.093 12.800  1.00 58.57  ? 223 PHE B CD2   1 
ATOM   3469 C  CE1   . PHE B 1 305 ? 33.728 -11.979 11.483  1.00 51.12  ? 223 PHE B CE1   1 
ATOM   3470 C  CE2   . PHE B 1 305 ? 35.289 -13.750 11.721  1.00 55.61  ? 223 PHE B CE2   1 
ATOM   3471 C  CZ    . PHE B 1 305 ? 34.231 -13.182 11.050  1.00 50.54  ? 223 PHE B CZ    1 
ATOM   3472 N  N     . LEU B 1 306 ? 35.026 -12.787 16.899  1.00 69.15  ? 224 LEU B N     1 
ATOM   3473 C  CA    . LEU B 1 306 ? 34.435 -13.949 17.555  1.00 78.97  ? 224 LEU B CA    1 
ATOM   3474 C  C     . LEU B 1 306 ? 33.308 -13.527 18.506  1.00 84.59  ? 224 LEU B C     1 
ATOM   3475 O  O     . LEU B 1 306 ? 32.241 -14.136 18.488  1.00 88.02  ? 224 LEU B O     1 
ATOM   3476 C  CB    . LEU B 1 306 ? 35.514 -14.744 18.297  1.00 76.68  ? 224 LEU B CB    1 
ATOM   3477 C  CG    . LEU B 1 306 ? 36.328 -15.754 17.477  1.00 76.61  ? 224 LEU B CG    1 
ATOM   3478 C  CD1   . LEU B 1 306 ? 37.585 -16.188 18.218  1.00 74.75  ? 224 LEU B CD1   1 
ATOM   3479 C  CD2   . LEU B 1 306 ? 35.509 -16.992 17.137  1.00 83.06  ? 224 LEU B CD2   1 
ATOM   3480 N  N     . ASP B 1 307 ? 33.544 -12.501 19.343  1.00 82.26  ? 225 ASP B N     1 
ATOM   3481 C  CA    . ASP B 1 307 ? 32.494 -11.972 20.207  1.00 82.04  ? 225 ASP B CA    1 
ATOM   3482 C  C     . ASP B 1 307 ? 31.259 -11.625 19.379  1.00 71.54  ? 225 ASP B C     1 
ATOM   3483 O  O     . ASP B 1 307 ? 30.155 -11.931 19.795  1.00 83.56  ? 225 ASP B O     1 
ATOM   3484 C  CB    . ASP B 1 307 ? 32.975 -10.838 21.103  1.00 76.38  ? 225 ASP B CB    1 
ATOM   3485 C  CG    . ASP B 1 307 ? 34.053 -11.273 22.083  1.00 81.47  ? 225 ASP B CG    1 
ATOM   3486 O  OD1   . ASP B 1 307 ? 34.155 -12.495 22.335  1.00 81.01  ? 225 ASP B OD1   1 
ATOM   3487 O  OD2   . ASP B 1 307 ? 34.847 -10.413 22.512  1.00 82.88  ? 225 ASP B OD2   1 
ATOM   3488 N  N     . TYR B 1 308 ? 31.433 -11.023 18.202  1.00 71.78  ? 226 TYR B N     1 
ATOM   3489 C  CA    . TYR B 1 308 ? 30.286 -10.661 17.380  1.00 71.43  ? 226 TYR B CA    1 
ATOM   3490 C  C     . TYR B 1 308 ? 29.607 -11.917 16.822  1.00 77.76  ? 226 TYR B C     1 
ATOM   3491 O  O     . TYR B 1 308 ? 28.380 -11.975 16.773  1.00 85.91  ? 226 TYR B O     1 
ATOM   3492 C  CB    . TYR B 1 308 ? 30.642 -9.693  16.250  1.00 65.49  ? 226 TYR B CB    1 
ATOM   3493 C  CG    . TYR B 1 308 ? 29.533 -9.543  15.218  1.00 58.66  ? 226 TYR B CG    1 
ATOM   3494 C  CD1   . TYR B 1 308 ? 28.457 -8.695  15.442  1.00 60.41  ? 226 TYR B CD1   1 
ATOM   3495 C  CD2   . TYR B 1 308 ? 29.538 -10.279 14.037  1.00 54.48  ? 226 TYR B CD2   1 
ATOM   3496 C  CE1   . TYR B 1 308 ? 27.429 -8.561  14.517  1.00 59.52  ? 226 TYR B CE1   1 
ATOM   3497 C  CE2   . TYR B 1 308 ? 28.517 -10.156 13.104  1.00 53.20  ? 226 TYR B CE2   1 
ATOM   3498 C  CZ    . TYR B 1 308 ? 27.454 -9.300  13.346  1.00 60.27  ? 226 TYR B CZ    1 
ATOM   3499 O  OH    . TYR B 1 308 ? 26.430 -9.179  12.440  1.00 63.36  ? 226 TYR B OH    1 
ATOM   3500 N  N     . LEU B 1 309 ? 30.385 -12.914 16.383  1.00 78.30  ? 227 LEU B N     1 
ATOM   3501 C  CA    . LEU B 1 309 ? 29.806 -14.122 15.809  1.00 80.94  ? 227 LEU B CA    1 
ATOM   3502 C  C     . LEU B 1 309 ? 28.968 -14.886 16.844  1.00 87.26  ? 227 LEU B C     1 
ATOM   3503 O  O     . LEU B 1 309 ? 27.938 -15.462 16.491  1.00 80.97  ? 227 LEU B O     1 
ATOM   3504 C  CB    . LEU B 1 309 ? 30.884 -15.037 15.235  1.00 74.75  ? 227 LEU B CB    1 
ATOM   3505 C  CG    . LEU B 1 309 ? 31.488 -14.658 13.883  1.00 74.64  ? 227 LEU B CG    1 
ATOM   3506 C  CD1   . LEU B 1 309 ? 32.459 -15.767 13.540  1.00 72.53  ? 227 LEU B CD1   1 
ATOM   3507 C  CD2   . LEU B 1 309 ? 30.494 -14.469 12.752  1.00 77.28  ? 227 LEU B CD2   1 
ATOM   3508 N  N     . ARG B 1 310 ? 29.424 -14.921 18.105  1.00 83.93  ? 228 ARG B N     1 
ATOM   3509 C  CA    . ARG B 1 310 ? 28.760 -15.684 19.152  1.00 82.08  ? 228 ARG B CA    1 
ATOM   3510 C  C     . ARG B 1 310 ? 27.460 -15.002 19.591  1.00 84.61  ? 228 ARG B C     1 
ATOM   3511 O  O     . ARG B 1 310 ? 26.472 -15.685 19.835  1.00 96.72  ? 228 ARG B O     1 
ATOM   3512 C  CB    . ARG B 1 310 ? 29.754 -15.952 20.286  1.00 77.88  ? 228 ARG B CB    1 
ATOM   3513 C  CG    . ARG B 1 310 ? 30.847 -16.899 19.811  1.00 85.93  ? 228 ARG B CG    1 
ATOM   3514 C  CD    . ARG B 1 310 ? 31.976 -16.986 20.820  1.00 95.09  ? 228 ARG B CD    1 
ATOM   3515 N  NE    . ARG B 1 310 ? 33.028 -17.921 20.408  1.00 96.37  ? 228 ARG B NE    1 
ATOM   3516 C  CZ    . ARG B 1 310 ? 34.130 -18.206 21.108  1.00 96.24  ? 228 ARG B CZ    1 
ATOM   3517 N  NH1   . ARG B 1 310 ? 34.400 -17.583 22.242  1.00 84.69  ? 228 ARG B NH1   1 
ATOM   3518 N  NH2   . ARG B 1 310 ? 34.973 -19.122 20.663  1.00 101.43 ? 228 ARG B NH2   1 
ATOM   3519 N  N     . ARG B 1 311 ? 27.454 -13.665 19.684  1.00 83.37  ? 229 ARG B N     1 
ATOM   3520 C  CA    . ARG B 1 311 ? 26.249 -12.916 20.000  1.00 82.56  ? 229 ARG B CA    1 
ATOM   3521 C  C     . ARG B 1 311 ? 25.213 -13.114 18.894  1.00 86.83  ? 229 ARG B C     1 
ATOM   3522 O  O     . ARG B 1 311 ? 24.069 -13.447 19.178  1.00 92.26  ? 229 ARG B O     1 
ATOM   3523 C  CB    . ARG B 1 311 ? 26.536 -11.423 20.189  1.00 83.66  ? 229 ARG B CB    1 
ATOM   3524 C  CG    . ARG B 1 311 ? 27.400 -11.095 21.399  1.00 90.98  ? 229 ARG B CG    1 
ATOM   3525 C  CD    . ARG B 1 311 ? 27.635 -9.590  21.570  1.00 100.25 ? 229 ARG B CD    1 
ATOM   3526 N  NE    . ARG B 1 311 ? 28.924 -9.096  21.061  1.00 105.54 ? 229 ARG B NE    1 
ATOM   3527 C  CZ    . ARG B 1 311 ? 29.130 -8.182  20.100  1.00 104.43 ? 229 ARG B CZ    1 
ATOM   3528 N  NH1   . ARG B 1 311 ? 28.140 -7.703  19.360  1.00 92.12  ? 229 ARG B NH1   1 
ATOM   3529 N  NH2   . ARG B 1 311 ? 30.362 -7.768  19.854  1.00 107.23 ? 229 ARG B NH2   1 
ATOM   3530 N  N     . GLU B 1 312 ? 25.619 -12.944 17.631  1.00 85.20  ? 230 GLU B N     1 
ATOM   3531 C  CA    . GLU B 1 312 ? 24.674 -12.869 16.527  1.00 87.81  ? 230 GLU B CA    1 
ATOM   3532 C  C     . GLU B 1 312 ? 24.438 -14.231 15.872  1.00 76.76  ? 230 GLU B C     1 
ATOM   3533 O  O     . GLU B 1 312 ? 23.403 -14.448 15.261  1.00 72.92  ? 230 GLU B O     1 
ATOM   3534 C  CB    . GLU B 1 312 ? 25.174 -11.869 15.486  1.00 94.52  ? 230 GLU B CB    1 
ATOM   3535 C  CG    . GLU B 1 312 ? 24.320 -11.787 14.218  1.00 92.40  ? 230 GLU B CG    1 
ATOM   3536 C  CD    . GLU B 1 312 ? 23.010 -11.036 14.360  1.00 93.51  ? 230 GLU B CD    1 
ATOM   3537 O  OE1   . GLU B 1 312 ? 22.854 -10.430 15.456  1.00 82.54  ? 230 GLU B OE1   1 
ATOM   3538 O  OE2   . GLU B 1 312 ? 22.187 -11.049 13.391  1.00 79.91  ? 230 GLU B OE2   1 
ATOM   3539 N  N     . PHE B 1 313 ? 25.393 -15.151 15.948  1.00 87.77  ? 231 PHE B N     1 
ATOM   3540 C  CA    . PHE B 1 313 ? 25.185 -16.477 15.381  1.00 93.16  ? 231 PHE B CA    1 
ATOM   3541 C  C     . PHE B 1 313 ? 25.362 -17.541 16.469  1.00 101.85 ? 231 PHE B C     1 
ATOM   3542 O  O     . PHE B 1 313 ? 26.324 -18.319 16.438  1.00 77.06  ? 231 PHE B O     1 
ATOM   3543 C  CB    . PHE B 1 313 ? 26.126 -16.638 14.181  1.00 84.63  ? 231 PHE B CB    1 
ATOM   3544 C  CG    . PHE B 1 313 ? 25.794 -15.703 13.029  1.00 72.05  ? 231 PHE B CG    1 
ATOM   3545 C  CD1   . PHE B 1 313 ? 24.821 -16.047 12.095  1.00 65.60  ? 231 PHE B CD1   1 
ATOM   3546 C  CD2   . PHE B 1 313 ? 26.450 -14.488 12.884  1.00 68.30  ? 231 PHE B CD2   1 
ATOM   3547 C  CE1   . PHE B 1 313 ? 24.497 -15.199 11.050  1.00 61.73  ? 231 PHE B CE1   1 
ATOM   3548 C  CE2   . PHE B 1 313 ? 26.121 -13.638 11.838  1.00 69.41  ? 231 PHE B CE2   1 
ATOM   3549 C  CZ    . PHE B 1 313 ? 25.148 -13.993 10.922  1.00 66.23  ? 231 PHE B CZ    1 
ATOM   3550 N  N     . PRO B 1 314 ? 24.428 -17.623 17.451  1.00 103.83 ? 232 PRO B N     1 
ATOM   3551 C  CA    . PRO B 1 314 ? 24.649 -18.450 18.638  1.00 108.62 ? 232 PRO B CA    1 
ATOM   3552 C  C     . PRO B 1 314 ? 24.805 -19.912 18.218  1.00 108.10 ? 232 PRO B C     1 
ATOM   3553 O  O     . PRO B 1 314 ? 24.000 -20.432 17.449  1.00 101.84 ? 232 PRO B O     1 
ATOM   3554 C  CB    . PRO B 1 314 ? 23.433 -18.182 19.552  1.00 105.94 ? 232 PRO B CB    1 
ATOM   3555 C  CG    . PRO B 1 314 ? 22.385 -17.558 18.640  1.00 105.49 ? 232 PRO B CG    1 
ATOM   3556 C  CD    . PRO B 1 314 ? 23.116 -16.956 17.452  1.00 97.53  ? 232 PRO B CD    1 
ATOM   3557 N  N     . THR B 1 315 ? 25.879 -20.539 18.710  1.00 110.22 ? 233 THR B N     1 
ATOM   3558 C  CA    . THR B 1 315 ? 26.288 -21.878 18.307  1.00 120.42 ? 233 THR B CA    1 
ATOM   3559 C  C     . THR B 1 315 ? 25.135 -22.872 18.529  1.00 129.83 ? 233 THR B C     1 
ATOM   3560 O  O     . THR B 1 315 ? 24.698 -23.052 19.663  1.00 136.39 ? 233 THR B O     1 
ATOM   3561 C  CB    . THR B 1 315 ? 27.597 -22.214 19.050  1.00 114.44 ? 233 THR B CB    1 
ATOM   3562 O  OG1   . THR B 1 315 ? 27.938 -23.561 18.748  1.00 113.59 ? 233 THR B OG1   1 
ATOM   3563 C  CG2   . THR B 1 315 ? 27.572 -22.069 20.568  1.00 99.68  ? 233 THR B CG2   1 
ATOM   3564 N  N     . PRO B 1 316 ? 24.562 -23.520 17.474  1.00 135.82 ? 234 PRO B N     1 
ATOM   3565 C  CA    . PRO B 1 316 ? 23.473 -24.488 17.666  1.00 127.62 ? 234 PRO B CA    1 
ATOM   3566 C  C     . PRO B 1 316 ? 23.922 -25.668 18.533  1.00 118.47 ? 234 PRO B C     1 
ATOM   3567 O  O     . PRO B 1 316 ? 23.047 -26.269 19.184  1.00 104.31 ? 234 PRO B O     1 
ATOM   3568 C  CB    . PRO B 1 316 ? 23.042 -24.949 16.250  1.00 121.37 ? 234 PRO B CB    1 
ATOM   3569 C  CG    . PRO B 1 316 ? 23.791 -24.048 15.279  1.00 115.80 ? 234 PRO B CG    1 
ATOM   3570 C  CD    . PRO B 1 316 ? 24.913 -23.358 16.050  1.00 123.22 ? 234 PRO B CD    1 
HETATM 3571 CO CO    . B12 C 2 .   ? 43.275 -13.092 -16.115 1.00 44.67  ? 301 B12 A CO    1 
HETATM 3572 N  N21   . B12 C 2 .   ? 43.590 -13.057 -17.911 1.00 47.20  ? 301 B12 A N21   1 
HETATM 3573 N  N22   . B12 C 2 .   ? 43.714 -11.265 -16.023 1.00 39.77  ? 301 B12 A N22   1 
HETATM 3574 N  N23   . B12 C 2 .   ? 43.143 -13.371 -14.252 1.00 40.34  ? 301 B12 A N23   1 
HETATM 3575 N  N24   . B12 C 2 .   ? 42.751 -14.887 -16.517 1.00 43.46  ? 301 B12 A N24   1 
HETATM 3576 C  C1    . B12 C 2 .   ? 43.901 -14.308 -18.585 1.00 47.28  ? 301 B12 A C1    1 
HETATM 3577 C  C20   . B12 C 2 .   ? 45.385 -14.645 -18.627 1.00 44.53  ? 301 B12 A C20   1 
HETATM 3578 C  C2    . B12 C 2 .   ? 43.346 -14.063 -19.991 1.00 51.21  ? 301 B12 A C2    1 
HETATM 3579 C  C25   . B12 C 2 .   ? 44.056 -14.870 -21.111 1.00 52.28  ? 301 B12 A C25   1 
HETATM 3580 C  C26   . B12 C 2 .   ? 41.840 -14.322 -20.063 1.00 47.45  ? 301 B12 A C26   1 
HETATM 3581 C  C27   . B12 C 2 .   ? 41.361 -14.055 -21.488 1.00 42.60  ? 301 B12 A C27   1 
HETATM 3582 O  O28   . B12 C 2 .   ? 41.014 -12.963 -21.863 1.00 39.14  ? 301 B12 A O28   1 
HETATM 3583 N  N29   . B12 C 2 .   ? 41.307 -15.068 -22.329 1.00 47.65  ? 301 B12 A N29   1 
HETATM 3584 C  C3    . B12 C 2 .   ? 43.547 -12.540 -20.095 1.00 50.46  ? 301 B12 A C3    1 
HETATM 3585 C  C30   . B12 C 2 .   ? 44.825 -12.076 -20.766 1.00 49.29  ? 301 B12 A C30   1 
HETATM 3586 C  C31   . B12 C 2 .   ? 44.565 -11.935 -22.248 1.00 54.79  ? 301 B12 A C31   1 
HETATM 3587 C  C32   . B12 C 2 .   ? 45.712 -11.202 -22.827 1.00 59.85  ? 301 B12 A C32   1 
HETATM 3588 O  O34   . B12 C 2 .   ? 45.503 -10.151 -23.392 1.00 71.13  ? 301 B12 A O34   1 
HETATM 3589 N  N33   . B12 C 2 .   ? 46.911 -11.745 -22.682 1.00 61.36  ? 301 B12 A N33   1 
HETATM 3590 C  C4    . B12 C 2 .   ? 43.484 -12.085 -18.686 1.00 43.66  ? 301 B12 A C4    1 
HETATM 3591 C  C5    . B12 C 2 .   ? 43.226 -10.703 -18.322 1.00 42.40  ? 301 B12 A C5    1 
HETATM 3592 C  C35   . B12 C 2 .   ? 42.878 -9.752  -19.445 1.00 40.96  ? 301 B12 A C35   1 
HETATM 3593 C  C6    . B12 C 2 .   ? 43.271 -10.347 -17.032 1.00 44.27  ? 301 B12 A C6    1 
HETATM 3594 C  C7    . B12 C 2 .   ? 43.032 -8.931  -16.494 1.00 49.75  ? 301 B12 A C7    1 
HETATM 3595 C  C36   . B12 C 2 .   ? 43.766 -7.801  -17.286 1.00 52.16  ? 301 B12 A C36   1 
HETATM 3596 C  C37   . B12 C 2 .   ? 41.527 -8.674  -16.501 1.00 43.92  ? 301 B12 A C37   1 
HETATM 3597 C  C38   . B12 C 2 .   ? 41.129 -7.265  -16.090 1.00 45.12  ? 301 B12 A C38   1 
HETATM 3598 O  O39   . B12 C 2 .   ? 40.579 -6.482  -16.867 1.00 48.84  ? 301 B12 A O39   1 
HETATM 3599 N  N40   . B12 C 2 .   ? 41.350 -6.937  -14.823 1.00 39.18  ? 301 B12 A N40   1 
HETATM 3600 C  C8    . B12 C 2 .   ? 43.674 -9.097  -15.088 1.00 45.04  ? 301 B12 A C8    1 
HETATM 3601 C  C41   . B12 C 2 .   ? 45.169 -8.664  -15.014 1.00 43.07  ? 301 B12 A C41   1 
HETATM 3602 C  C42   . B12 C 2 .   ? 45.884 -8.867  -13.634 1.00 43.73  ? 301 B12 A C42   1 
HETATM 3603 C  C43   . B12 C 2 .   ? 47.403 -8.952  -13.811 1.00 43.55  ? 301 B12 A C43   1 
HETATM 3604 O  O44   . B12 C 2 .   ? 48.030 -9.999  -13.856 1.00 43.43  ? 301 B12 A O44   1 
HETATM 3605 N  N45   . B12 C 2 .   ? 48.026 -7.812  -13.955 1.00 41.90  ? 301 B12 A N45   1 
HETATM 3606 C  C9    . B12 C 2 .   ? 43.545 -10.571 -14.858 1.00 39.10  ? 301 B12 A C9    1 
HETATM 3607 C  C10   . B12 C 2 .   ? 43.374 -11.145 -13.543 1.00 38.68  ? 301 B12 A C10   1 
HETATM 3608 C  C11   . B12 C 2 .   ? 43.196 -12.432 -13.320 1.00 38.14  ? 301 B12 A C11   1 
HETATM 3609 C  C12   . B12 C 2 .   ? 43.039 -12.897 -11.899 1.00 39.55  ? 301 B12 A C12   1 
HETATM 3610 C  C46   . B12 C 2 .   ? 41.758 -12.448 -11.266 1.00 40.42  ? 301 B12 A C46   1 
HETATM 3611 C  C47   . B12 C 2 .   ? 44.152 -12.248 -11.060 1.00 41.46  ? 301 B12 A C47   1 
HETATM 3612 C  C13   . B12 C 2 .   ? 43.024 -14.401 -12.107 1.00 37.41  ? 301 B12 A C13   1 
HETATM 3613 C  C48   . B12 C 2 .   ? 44.212 -15.129 -11.497 1.00 39.59  ? 301 B12 A C48   1 
HETATM 3614 C  C49   . B12 C 2 .   ? 44.117 -15.492 -10.013 1.00 42.41  ? 301 B12 A C49   1 
HETATM 3615 C  C50   . B12 C 2 .   ? 45.480 -16.020 -9.491  1.00 47.71  ? 301 B12 A C50   1 
HETATM 3616 O  O51   . B12 C 2 .   ? 46.282 -16.645 -10.177 1.00 41.66  ? 301 B12 A O51   1 
HETATM 3617 N  N52   . B12 C 2 .   ? 45.784 -15.778 -8.217  1.00 42.70  ? 301 B12 A N52   1 
HETATM 3618 C  C14   . B12 C 2 .   ? 43.017 -14.489 -13.630 1.00 39.16  ? 301 B12 A C14   1 
HETATM 3619 C  C15   . B12 C 2 .   ? 42.875 -15.797 -14.277 1.00 39.23  ? 301 B12 A C15   1 
HETATM 3620 C  C53   . B12 C 2 .   ? 42.509 -16.973 -13.361 1.00 42.22  ? 301 B12 A C53   1 
HETATM 3621 C  C16   . B12 C 2 .   ? 42.938 -15.938 -15.603 1.00 39.72  ? 301 B12 A C16   1 
HETATM 3622 C  C17   . B12 C 2 .   ? 42.846 -17.230 -16.387 1.00 42.55  ? 301 B12 A C17   1 
HETATM 3623 C  C54   . B12 C 2 .   ? 41.333 -17.470 -16.520 1.00 46.80  ? 301 B12 A C54   1 
HETATM 3624 C  C55   . B12 C 2 .   ? 43.502 -18.483 -15.816 1.00 45.18  ? 301 B12 A C55   1 
HETATM 3625 C  C56   . B12 C 2 .   ? 44.966 -18.304 -15.443 1.00 40.79  ? 301 B12 A C56   1 
HETATM 3626 C  C57   . B12 C 2 .   ? 45.560 -19.609 -15.087 1.00 37.08  ? 301 B12 A C57   1 
HETATM 3627 O  O58   . B12 C 2 .   ? 45.648 -19.933 -13.907 1.00 41.79  ? 301 B12 A O58   1 
HETATM 3628 N  N59   . B12 C 2 .   ? 45.962 -20.393 -16.075 1.00 36.15  ? 301 B12 A N59   1 
HETATM 3629 C  C18   . B12 C 2 .   ? 43.481 -16.824 -17.689 1.00 43.95  ? 301 B12 A C18   1 
HETATM 3630 C  C60   . B12 C 2 .   ? 43.021 -17.618 -18.910 1.00 45.39  ? 301 B12 A C60   1 
HETATM 3631 C  C61   . B12 C 2 .   ? 44.247 -18.388 -19.344 1.00 49.98  ? 301 B12 A C61   1 
HETATM 3632 O  O63   . B12 C 2 .   ? 45.049 -18.824 -18.513 1.00 50.34  ? 301 B12 A O63   1 
HETATM 3633 N  N62   . B12 C 2 .   ? 44.409 -18.535 -20.651 1.00 45.20  ? 301 B12 A N62   1 
HETATM 3634 C  C19   . B12 C 2 .   ? 43.311 -15.347 -17.682 1.00 41.65  ? 301 B12 A C19   1 
HETATM 3635 C  C1P   . B12 C 2 .   ? 46.460 -21.719 -15.692 1.00 39.69  ? 301 B12 A C1P   1 
HETATM 3636 C  C2P   . B12 C 2 .   ? 47.864 -22.004 -16.179 1.00 41.06  ? 301 B12 A C2P   1 
HETATM 3637 C  C3P   . B12 C 2 .   ? 48.277 -23.367 -15.623 1.00 41.88  ? 301 B12 A C3P   1 
HETATM 3638 O  O3    . B12 C 2 .   ? 47.861 -22.016 -17.613 1.00 41.39  ? 301 B12 A O3    1 
HETATM 3639 O  O4    . B12 C 2 .   ? 49.525 -20.216 -17.775 1.00 42.73  ? 301 B12 A O4    1 
HETATM 3640 O  O5    . B12 C 2 .   ? 48.871 -21.611 -19.892 1.00 43.08  ? 301 B12 A O5    1 
HETATM 3641 P  P     . B12 C 2 .   ? 49.139 -21.532 -18.389 1.00 43.49  ? 301 B12 A P     1 
HETATM 3642 O  O2    . B12 C 2 .   ? 50.386 -22.401 -17.880 1.00 41.73  ? 301 B12 A O2    1 
HETATM 3643 C  C3R   . B12 C 2 .   ? 50.876 -23.577 -18.522 1.00 45.52  ? 301 B12 A C3R   1 
HETATM 3644 C  C2R   . B12 C 2 .   ? 52.065 -23.258 -19.374 1.00 44.82  ? 301 B12 A C2R   1 
HETATM 3645 O  O7R   . B12 C 2 .   ? 52.083 -21.884 -19.774 1.00 43.85  ? 301 B12 A O7R   1 
HETATM 3646 C  C1R   . B12 C 2 .   ? 53.259 -23.717 -18.520 1.00 49.97  ? 301 B12 A C1R   1 
HETATM 3647 O  O6R   . B12 C 2 .   ? 52.768 -24.845 -17.774 1.00 45.24  ? 301 B12 A O6R   1 
HETATM 3648 C  C4R   . B12 C 2 .   ? 51.379 -24.663 -17.542 1.00 47.64  ? 301 B12 A C4R   1 
HETATM 3649 C  C5R   . B12 C 2 .   ? 50.689 -26.030 -17.672 1.00 48.55  ? 301 B12 A C5R   1 
HETATM 3650 O  O8R   . B12 C 2 .   ? 51.174 -26.727 -18.826 1.00 55.57  ? 301 B12 A O8R   1 
HETATM 3651 N  N1B   . B12 C 2 .   ? 53.890 -22.640 -17.638 1.00 47.20  ? 301 B12 A N1B   1 
HETATM 3652 C  C8B   . B12 C 2 .   ? 55.139 -22.715 -17.150 1.00 47.39  ? 301 B12 A C8B   1 
HETATM 3653 C  C2B   . B12 C 2 .   ? 53.353 -21.514 -17.175 1.00 42.89  ? 301 B12 A C2B   1 
HETATM 3654 N  N3B   . B12 C 2 .   ? 54.224 -20.800 -16.438 1.00 42.43  ? 301 B12 A N3B   1 
HETATM 3655 C  C9B   . B12 C 2 .   ? 55.364 -21.488 -16.353 1.00 46.06  ? 301 B12 A C9B   1 
HETATM 3656 C  C4B   . B12 C 2 .   ? 56.606 -21.270 -15.734 1.00 44.06  ? 301 B12 A C4B   1 
HETATM 3657 C  C5B   . B12 C 2 .   ? 57.623 -22.213 -15.846 1.00 41.02  ? 301 B12 A C5B   1 
HETATM 3658 C  C5M   . B12 C 2 .   ? 58.934 -21.958 -15.161 1.00 41.67  ? 301 B12 A C5M   1 
HETATM 3659 C  C6B   . B12 C 2 .   ? 57.401 -23.450 -16.639 1.00 44.73  ? 301 B12 A C6B   1 
HETATM 3660 C  C6M   . B12 C 2 .   ? 58.484 -24.490 -16.757 1.00 43.61  ? 301 B12 A C6M   1 
HETATM 3661 C  C7B   . B12 C 2 .   ? 56.167 -23.667 -17.259 1.00 45.22  ? 301 B12 A C7B   1 
HETATM 3662 N  N1    . 5AD D 3 .   ? 38.354 -7.119  -11.332 1.00 42.88  ? 302 5AD A N1    1 
HETATM 3663 C  C2    . 5AD D 3 .   ? 38.792 -8.340  -11.009 1.00 45.13  ? 302 5AD A C2    1 
HETATM 3664 N  N3    . 5AD D 3 .   ? 38.989 -9.398  -11.804 1.00 43.97  ? 302 5AD A N3    1 
HETATM 3665 C  C4    . 5AD D 3 .   ? 38.652 -9.121  -13.067 1.00 37.96  ? 302 5AD A C4    1 
HETATM 3666 N  N9    . 5AD D 3 .   ? 38.741 -9.950  -14.148 1.00 44.85  ? 302 5AD A N9    1 
HETATM 3667 C  C8    . 5AD D 3 .   ? 38.299 -9.246  -15.233 1.00 43.43  ? 302 5AD A C8    1 
HETATM 3668 N  N7    . 5AD D 3 .   ? 37.995 -8.008  -14.926 1.00 44.73  ? 302 5AD A N7    1 
HETATM 3669 C  C5    . 5AD D 3 .   ? 38.216 -7.921  -13.555 1.00 37.43  ? 302 5AD A C5    1 
HETATM 3670 C  C6    . 5AD D 3 .   ? 38.038 -6.883  -12.630 1.00 42.64  ? 302 5AD A C6    1 
HETATM 3671 N  N6    . 5AD D 3 .   ? 37.581 -5.677  -12.981 1.00 48.45  ? 302 5AD A N6    1 
HETATM 3672 C  "C1'" . 5AD D 3 .   ? 39.114 -11.336 -14.126 1.00 50.16  ? 302 5AD A "C1'" 1 
HETATM 3673 C  "C2'" . 5AD D 3 .   ? 38.028 -12.186 -14.805 1.00 53.18  ? 302 5AD A "C2'" 1 
HETATM 3674 C  "C3'" . 5AD D 3 .   ? 38.787 -12.905 -15.934 1.00 54.55  ? 302 5AD A "C3'" 1 
HETATM 3675 C  "C4'" . 5AD D 3 .   ? 40.254 -12.761 -15.526 1.00 51.89  ? 302 5AD A "C4'" 1 
HETATM 3676 C  "C5'" . 5AD D 3 .   ? 41.217 -12.754 -16.682 1.00 42.59  ? 302 5AD A "C5'" 1 
HETATM 3677 O  "O4'" . 5AD D 3 .   ? 40.318 -11.495 -14.834 1.00 49.88  ? 302 5AD A "O4'" 1 
HETATM 3678 O  "O2'" . 5AD D 3 .   ? 37.413 -13.058 -13.880 1.00 50.29  ? 302 5AD A "O2'" 1 
HETATM 3679 O  "O3'" . 5AD D 3 .   ? 38.484 -14.288 -16.070 1.00 57.46  ? 302 5AD A "O3'" 1 
HETATM 3680 CO CO    . B12 E 2 .   ? 51.466 -3.583  1.008   1.00 43.14  ? 301 B12 B CO    1 
HETATM 3681 N  N21   . B12 E 2 .   ? 51.138 -2.069  1.987   1.00 46.76  ? 301 B12 B N21   1 
HETATM 3682 N  N22   . B12 E 2 .   ? 50.956 -2.633  -0.563  1.00 39.32  ? 301 B12 B N22   1 
HETATM 3683 N  N23   . B12 E 2 .   ? 51.611 -5.253  0.188   1.00 40.86  ? 301 B12 B N23   1 
HETATM 3684 N  N24   . B12 E 2 .   ? 52.029 -4.216  2.712   1.00 39.82  ? 301 B12 B N24   1 
HETATM 3685 C  C1    . B12 E 2 .   ? 50.834 -2.191  3.389   1.00 47.67  ? 301 B12 B C1    1 
HETATM 3686 C  C20   . B12 E 2 .   ? 49.327 -2.410  3.620   1.00 49.05  ? 301 B12 B C20   1 
HETATM 3687 C  C2    . B12 E 2 .   ? 51.398 -0.849  3.979   1.00 50.96  ? 301 B12 B C2    1 
HETATM 3688 C  C25   . B12 E 2 .   ? 50.691 -0.418  5.292   1.00 51.34  ? 301 B12 B C25   1 
HETATM 3689 C  C26   . B12 E 2 .   ? 52.911 -0.791  4.200   1.00 52.85  ? 301 B12 B C26   1 
HETATM 3690 C  C27   . B12 E 2 .   ? 53.480 0.532   4.777   1.00 51.87  ? 301 B12 B C27   1 
HETATM 3691 O  O28   . B12 E 2 .   ? 53.587 1.556   4.107   1.00 48.99  ? 301 B12 B O28   1 
HETATM 3692 N  N29   . B12 E 2 .   ? 53.892 0.498   6.038   1.00 52.25  ? 301 B12 B N29   1 
HETATM 3693 C  C3    . B12 E 2 .   ? 51.172 0.066   2.783   1.00 51.89  ? 301 B12 B C3    1 
HETATM 3694 C  C30   . B12 E 2 .   ? 49.863 0.838   2.825   1.00 57.25  ? 301 B12 B C30   1 
HETATM 3695 C  C31   . B12 E 2 .   ? 50.142 2.236   3.354   1.00 61.42  ? 301 B12 B C31   1 
HETATM 3696 C  C32   . B12 E 2 .   ? 48.979 3.063   2.976   1.00 58.78  ? 301 B12 B C32   1 
HETATM 3697 O  O34   . B12 E 2 .   ? 49.205 4.048   2.360   1.00 68.70  ? 301 B12 B O34   1 
HETATM 3698 N  N33   . B12 E 2 .   ? 47.755 2.659   3.257   1.00 66.92  ? 301 B12 B N33   1 
HETATM 3699 C  C4    . B12 E 2 .   ? 51.239 -0.862  1.621   1.00 47.93  ? 301 B12 B C4    1 
HETATM 3700 C  C5    . B12 E 2 .   ? 51.482 -0.397  0.259   1.00 47.28  ? 301 B12 B C5    1 
HETATM 3701 C  C35   . B12 E 2 .   ? 51.828 1.065   0.144   1.00 41.91  ? 301 B12 B C35   1 
HETATM 3702 C  C6    . B12 E 2 .   ? 51.413 -1.283  -0.775  1.00 44.97  ? 301 B12 B C6    1 
HETATM 3703 C  C7    . B12 E 2 .   ? 51.669 -0.983  -2.267  1.00 44.22  ? 301 B12 B C7    1 
HETATM 3704 C  C36   . B12 E 2 .   ? 51.044 0.333   -2.802  1.00 45.37  ? 301 B12 B C36   1 
HETATM 3705 C  C37   . B12 E 2 .   ? 53.169 -0.912  -2.492  1.00 44.53  ? 301 B12 B C37   1 
HETATM 3706 C  C38   . B12 E 2 .   ? 53.514 -0.606  -3.958  1.00 40.80  ? 301 B12 B C38   1 
HETATM 3707 O  O39   . B12 E 2 .   ? 53.435 -1.409  -4.827  1.00 41.81  ? 301 B12 B O39   1 
HETATM 3708 N  N40   . B12 E 2 .   ? 53.942 0.601   -4.264  1.00 44.95  ? 301 B12 B N40   1 
HETATM 3709 C  C8    . B12 E 2 .   ? 51.085 -2.246  -2.936  1.00 40.41  ? 301 B12 B C8    1 
HETATM 3710 C  C41   . B12 E 2 .   ? 49.632 -2.124  -3.331  1.00 42.17  ? 301 B12 B C41   1 
HETATM 3711 C  C42   . B12 E 2 .   ? 48.983 -3.444  -3.819  1.00 48.85  ? 301 B12 B C42   1 
HETATM 3712 C  C43   . B12 E 2 .   ? 47.476 -3.410  -3.705  1.00 45.60  ? 301 B12 B C43   1 
HETATM 3713 O  O44   . B12 E 2 .   ? 46.869 -3.944  -2.782  1.00 50.82  ? 301 B12 B O44   1 
HETATM 3714 N  N45   . B12 E 2 .   ? 46.856 -2.739  -4.628  1.00 39.87  ? 301 B12 B N45   1 
HETATM 3715 C  C9    . B12 E 2 .   ? 51.177 -3.222  -1.809  1.00 39.29  ? 301 B12 B C9    1 
HETATM 3716 C  C10   . B12 E 2 .   ? 51.421 -4.608  -2.080  1.00 37.54  ? 301 B12 B C10   1 
HETATM 3717 C  C11   . B12 E 2 .   ? 51.565 -5.507  -1.140  1.00 37.97  ? 301 B12 B C11   1 
HETATM 3718 C  C12   . B12 E 2 .   ? 51.760 -6.941  -1.557  1.00 37.49  ? 301 B12 B C12   1 
HETATM 3719 C  C46   . B12 E 2 .   ? 53.084 -7.152  -2.265  1.00 36.39  ? 301 B12 B C46   1 
HETATM 3720 C  C47   . B12 E 2 .   ? 50.695 -7.422  -2.529  1.00 39.79  ? 301 B12 B C47   1 
HETATM 3721 C  C13   . B12 E 2 .   ? 51.747 -7.591  -0.178  1.00 41.31  ? 301 B12 B C13   1 
HETATM 3722 C  C48   . B12 E 2 .   ? 50.528 -8.514  0.026   1.00 43.90  ? 301 B12 B C48   1 
HETATM 3723 C  C49   . B12 E 2 .   ? 50.775 -9.994  -0.039  1.00 44.08  ? 301 B12 B C49   1 
HETATM 3724 C  C50   . B12 E 2 .   ? 49.449 -10.731 -0.036  1.00 49.70  ? 301 B12 B C50   1 
HETATM 3725 O  O51   . B12 E 2 .   ? 48.651 -10.560 0.888   1.00 48.91  ? 301 B12 B O51   1 
HETATM 3726 N  N52   . B12 E 2 .   ? 49.224 -11.557 -1.059  1.00 45.08  ? 301 B12 B N52   1 
HETATM 3727 C  C14   . B12 E 2 .   ? 51.770 -6.376  0.770   1.00 38.86  ? 301 B12 B C14   1 
HETATM 3728 C  C15   . B12 E 2 .   ? 51.955 -6.554  2.190   1.00 38.68  ? 301 B12 B C15   1 
HETATM 3729 C  C53   . B12 E 2 .   ? 52.387 -7.939  2.601   1.00 42.01  ? 301 B12 B C53   1 
HETATM 3730 C  C16   . B12 E 2 .   ? 51.857 -5.556  3.058   1.00 41.41  ? 301 B12 B C16   1 
HETATM 3731 C  C17   . B12 E 2 .   ? 51.841 -5.624  4.574   1.00 45.80  ? 301 B12 B C17   1 
HETATM 3732 C  C54   . B12 E 2 .   ? 53.327 -5.615  4.994   1.00 44.89  ? 301 B12 B C54   1 
HETATM 3733 C  C55   . B12 E 2 .   ? 51.189 -6.827  5.253   1.00 47.16  ? 301 B12 B C55   1 
HETATM 3734 C  C56   . B12 E 2 .   ? 49.714 -7.064  5.002   1.00 49.97  ? 301 B12 B C56   1 
HETATM 3735 C  C57   . B12 E 2 .   ? 49.307 -8.083  6.030   1.00 53.60  ? 301 B12 B C57   1 
HETATM 3736 O  O58   . B12 E 2 .   ? 49.320 -9.269  5.743   1.00 43.24  ? 301 B12 B O58   1 
HETATM 3737 N  N59   . B12 E 2 .   ? 49.027 -7.569  7.229   1.00 56.82  ? 301 B12 B N59   1 
HETATM 3738 C  C18   . B12 E 2 .   ? 51.194 -4.300  4.964   1.00 48.89  ? 301 B12 B C18   1 
HETATM 3739 C  C60   . B12 E 2 .   ? 51.772 -3.739  6.272   1.00 49.87  ? 301 B12 B C60   1 
HETATM 3740 C  C61   . B12 E 2 .   ? 50.639 -3.631  7.233   1.00 50.47  ? 301 B12 B C61   1 
HETATM 3741 O  O63   . B12 E 2 .   ? 49.734 -4.440  7.271   1.00 50.11  ? 301 B12 B O63   1 
HETATM 3742 N  N62   . B12 E 2 .   ? 50.679 -2.596  8.023   1.00 56.26  ? 301 B12 B N62   1 
HETATM 3743 C  C19   . B12 E 2 .   ? 51.405 -3.512  3.723   1.00 40.46  ? 301 B12 B C19   1 
HETATM 3744 C  C1P   . B12 E 2 .   ? 48.792 -8.372  8.397   1.00 53.36  ? 301 B12 B C1P   1 
HETATM 3745 C  C2P   . B12 E 2 .   ? 47.299 -8.386  8.690   1.00 57.47  ? 301 B12 B C2P   1 
HETATM 3746 C  C3P   . B12 E 2 .   ? 46.891 -9.755  9.268   1.00 57.79  ? 301 B12 B C3P   1 
HETATM 3747 O  O3    . B12 E 2 .   ? 46.977 -7.317  9.590   1.00 50.54  ? 301 B12 B O3    1 
HETATM 3748 O  O4    . B12 E 2 .   ? 45.401 -6.126  7.890   1.00 41.31  ? 301 B12 B O4    1 
HETATM 3749 O  O5    . B12 E 2 .   ? 45.923 -5.318  10.339  1.00 55.95  ? 301 B12 B O5    1 
HETATM 3750 P  P     . B12 E 2 .   ? 45.672 -6.439  9.338   1.00 52.39  ? 301 B12 B P     1 
HETATM 3751 O  O2    . B12 E 2 .   ? 44.438 -7.402  9.781   1.00 53.63  ? 301 B12 B O2    1 
HETATM 3752 C  C3R   . B12 E 2 .   ? 44.051 -7.358  11.176  1.00 57.78  ? 301 B12 B C3R   1 
HETATM 3753 C  C2R   . B12 E 2 .   ? 42.793 -6.562  11.345  1.00 50.41  ? 301 B12 B C2R   1 
HETATM 3754 O  O7R   . B12 E 2 .   ? 42.752 -5.503  10.407  1.00 47.57  ? 301 B12 B O7R   1 
HETATM 3755 C  C1R   . B12 E 2 .   ? 41.652 -7.534  11.204  1.00 50.24  ? 301 B12 B C1R   1 
HETATM 3756 O  O6R   . B12 E 2 .   ? 42.253 -8.795  11.500  1.00 66.09  ? 301 B12 B O6R   1 
HETATM 3757 C  C4R   . B12 E 2 .   ? 43.649 -8.689  11.773  1.00 59.72  ? 301 B12 B C4R   1 
HETATM 3758 C  C5R   . B12 E 2 .   ? 43.863 -8.714  13.276  1.00 62.77  ? 301 B12 B C5R   1 
HETATM 3759 O  O8R   . B12 E 2 .   ? 44.744 -9.776  13.548  1.00 72.19  ? 301 B12 B O8R   1 
HETATM 3760 N  N1B   . B12 E 2 .   ? 41.038 -7.591  9.865   1.00 49.53  ? 301 B12 B N1B   1 
HETATM 3761 C  C8B   . B12 E 2 .   ? 39.822 -8.071  9.627   1.00 52.08  ? 301 B12 B C8B   1 
HETATM 3762 C  C2B   . B12 E 2 .   ? 41.557 -7.218  8.686   1.00 51.66  ? 301 B12 B C2B   1 
HETATM 3763 N  N3B   . B12 E 2 .   ? 40.692 -7.413  7.668   1.00 44.04  ? 301 B12 B N3B   1 
HETATM 3764 C  C9B   . B12 E 2 .   ? 39.576 -7.962  8.175   1.00 52.56  ? 301 B12 B C9B   1 
HETATM 3765 C  C4B   . B12 E 2 .   ? 38.350 -8.373  7.615   1.00 54.94  ? 301 B12 B C4B   1 
HETATM 3766 C  C5B   . B12 E 2 .   ? 37.369 -8.926  8.420   1.00 52.03  ? 301 B12 B C5B   1 
HETATM 3767 C  C5M   . B12 E 2 .   ? 36.057 -9.386  7.815   1.00 50.88  ? 301 B12 B C5M   1 
HETATM 3768 C  C6B   . B12 E 2 .   ? 37.631 -9.022  9.886   1.00 52.92  ? 301 B12 B C6B   1 
HETATM 3769 C  C6M   . B12 E 2 .   ? 36.588 -9.624  10.799  1.00 57.12  ? 301 B12 B C6M   1 
HETATM 3770 C  C7B   . B12 E 2 .   ? 38.837 -8.588  10.443  1.00 53.66  ? 301 B12 B C7B   1 
HETATM 3771 N  N1    . 5AD F 3 .   ? 56.319 -4.548  -6.737  1.00 42.02  ? 302 5AD B N1    1 
HETATM 3772 C  C2    . 5AD F 3 .   ? 55.946 -5.471  -5.836  1.00 40.62  ? 302 5AD B C2    1 
HETATM 3773 N  N3    . 5AD F 3 .   ? 55.788 -5.351  -4.519  1.00 37.78  ? 302 5AD B N3    1 
HETATM 3774 C  C4    . 5AD F 3 .   ? 56.040 -4.098  -4.124  1.00 41.12  ? 302 5AD B C4    1 
HETATM 3775 N  N9    . 5AD F 3 .   ? 55.974 -3.603  -2.854  1.00 46.49  ? 302 5AD B N9    1 
HETATM 3776 C  C8    . 5AD F 3 .   ? 56.345 -2.279  -2.929  1.00 46.48  ? 302 5AD B C8    1 
HETATM 3777 N  N7    . 5AD F 3 .   ? 56.621 -1.906  -4.161  1.00 44.08  ? 302 5AD B N7    1 
HETATM 3778 C  C5    . 5AD F 3 .   ? 56.433 -3.046  -4.924  1.00 42.83  ? 302 5AD B C5    1 
HETATM 3779 C  C6    . 5AD F 3 .   ? 56.577 -3.299  -6.296  1.00 40.49  ? 302 5AD B C6    1 
HETATM 3780 N  N6    . 5AD F 3 .   ? 56.912 -2.367  -7.182  1.00 45.24  ? 302 5AD B N6    1 
HETATM 3781 C  "C1'" . 5AD F 3 .   ? 55.664 -4.349  -1.655  1.00 46.69  ? 302 5AD B "C1'" 1 
HETATM 3782 C  "C2'" . 5AD F 3 .   ? 56.735 -4.212  -0.564  1.00 46.57  ? 302 5AD B "C2'" 1 
HETATM 3783 C  "C3'" . 5AD F 3 .   ? 55.962 -3.669  0.644   1.00 50.18  ? 302 5AD B "C3'" 1 
HETATM 3784 C  "C4'" . 5AD F 3 .   ? 54.520 -3.994  0.288   1.00 47.80  ? 302 5AD B "C4'" 1 
HETATM 3785 C  "C5'" . 5AD F 3 .   ? 53.529 -3.060  0.908   1.00 53.13  ? 302 5AD B "C5'" 1 
HETATM 3786 O  "O4'" . 5AD F 3 .   ? 54.452 -3.854  -1.143  1.00 42.20  ? 302 5AD B "O4'" 1 
HETATM 3787 O  "O2'" . 5AD F 3 .   ? 57.336 -5.436  -0.220  1.00 42.26  ? 302 5AD B "O2'" 1 
HETATM 3788 O  "O3'" . 5AD F 3 .   ? 56.325 -4.264  1.887   1.00 45.55  ? 302 5AD B "O3'" 1 
HETATM 3789 O  O     . HOH G 4 .   ? 58.540 -0.126  -19.707 1.00 44.88  ? 401 HOH A O     1 
HETATM 3790 O  O     . HOH G 4 .   ? 46.644 -17.976 -12.555 1.00 39.84  ? 402 HOH A O     1 
HETATM 3791 O  O     . HOH G 4 .   ? 51.788 -15.858 -14.733 1.00 45.42  ? 403 HOH A O     1 
HETATM 3792 O  O     . HOH G 4 .   ? 49.087 -18.922 -13.439 1.00 46.84  ? 404 HOH A O     1 
HETATM 3793 O  O     . HOH G 4 .   ? 53.211 -4.057  -8.933  1.00 48.70  ? 405 HOH A O     1 
HETATM 3794 O  O     . HOH G 4 .   ? 50.682 -18.036 -18.967 1.00 42.64  ? 406 HOH A O     1 
HETATM 3795 O  O     . HOH G 4 .   ? 54.944 -13.084 -2.479  1.00 49.89  ? 407 HOH A O     1 
HETATM 3796 O  O     . HOH G 4 .   ? 54.543 -1.732  -9.186  1.00 45.71  ? 408 HOH A O     1 
HETATM 3797 O  O     . HOH G 4 .   ? 63.616 6.240   -21.017 1.00 39.85  ? 409 HOH A O     1 
HETATM 3798 O  O     . HOH G 4 .   ? 53.257 -10.540 -4.499  1.00 42.69  ? 410 HOH A O     1 
HETATM 3799 O  O     . HOH G 4 .   ? 60.590 -26.358 -0.673  1.00 40.11  ? 411 HOH A O     1 
HETATM 3800 O  O     . HOH G 4 .   ? 51.869 -18.474 -12.585 1.00 39.06  ? 412 HOH A O     1 
HETATM 3801 O  O     . HOH G 4 .   ? 54.772 -5.751  -17.169 1.00 35.16  ? 413 HOH A O     1 
HETATM 3802 O  O     . HOH G 4 .   ? 56.470 -29.088 0.944   1.00 54.62  ? 414 HOH A O     1 
HETATM 3803 O  O     . HOH G 4 .   ? 41.899 -17.790 -22.055 1.00 45.61  ? 415 HOH A O     1 
HETATM 3804 O  O     . HOH G 4 .   ? 45.880 -40.524 -1.358  1.00 58.21  ? 416 HOH A O     1 
HETATM 3805 O  O     . HOH G 4 .   ? 72.874 -17.622 -22.641 1.00 58.50  ? 417 HOH A O     1 
HETATM 3806 O  O     . HOH G 4 .   ? 65.194 -21.132 -26.124 1.00 51.44  ? 418 HOH A O     1 
HETATM 3807 O  O     . HOH G 4 .   ? 67.499 -16.925 -24.247 1.00 47.78  ? 419 HOH A O     1 
HETATM 3808 O  O     . HOH G 4 .   ? 66.087 0.038   -23.025 1.00 61.15  ? 420 HOH A O     1 
HETATM 3809 O  O     . HOH G 4 .   ? 40.140 -3.828  -15.294 1.00 60.00  ? 421 HOH A O     1 
HETATM 3810 O  O     . HOH H 4 .   ? 31.933 10.954  -5.500  1.00 53.45  ? 401 HOH B O     1 
HETATM 3811 O  O     . HOH H 4 .   ? 44.488 -4.174  6.621   1.00 45.54  ? 402 HOH B O     1 
HETATM 3812 O  O     . HOH H 4 .   ? 40.442 -4.201  11.757  1.00 57.13  ? 403 HOH B O     1 
HETATM 3813 O  O     . HOH H 4 .   ? 46.818 -11.131 -3.803  1.00 44.83  ? 404 HOH B O     1 
HETATM 3814 O  O     . HOH H 4 .   ? 46.289 -6.184  5.458   1.00 44.03  ? 405 HOH B O     1 
HETATM 3815 O  O     . HOH H 4 .   ? 40.073 -3.542  -11.756 1.00 46.69  ? 406 HOH B O     1 
HETATM 3816 O  O     . HOH H 4 .   ? 55.914 7.500   5.441   1.00 54.34  ? 407 HOH B O     1 
HETATM 3817 O  O     . HOH H 4 .   ? 42.910 -6.336  2.762   1.00 49.87  ? 408 HOH B O     1 
HETATM 3818 O  O     . HOH H 4 .   ? 48.106 -9.307  3.243   1.00 37.36  ? 409 HOH B O     1 
HETATM 3819 O  O     . HOH H 4 .   ? 43.262 -21.671 11.703  1.00 44.11  ? 410 HOH B O     1 
HETATM 3820 O  O     . HOH H 4 .   ? 41.613 -12.365 -7.410  1.00 38.11  ? 411 HOH B O     1 
HETATM 3821 O  O     . HOH H 4 .   ? 43.095 -9.383  3.585   1.00 45.39  ? 412 HOH B O     1 
HETATM 3822 O  O     . HOH H 4 .   ? 43.443 -22.302 19.269  1.00 46.35  ? 413 HOH B O     1 
HETATM 3823 O  O     . HOH H 4 .   ? 45.779 -8.790  4.273   1.00 40.92  ? 414 HOH B O     1 
HETATM 3824 O  O     . HOH H 4 .   ? 65.160 -20.159 9.153   1.00 63.25  ? 415 HOH B O     1 
HETATM 3825 O  O     . HOH H 4 .   ? 62.649 -8.704  14.386  1.00 51.07  ? 416 HOH B O     1 
# 
