data_9J9J
# 
_entry.id   9J9J 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9J9J         pdb_00009j9j 10.2210/pdb9j9j/pdb 
WWPDB D_1300049235 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-30 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9J9J 
_pdbx_database_status.recvd_initial_deposition_date   2024-08-22 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              yangjian@scsio.ac.cn 
_pdbx_contact_author.name_first         Jian 
_pdbx_contact_author.name_last          Yang 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-7624-6045 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Yang, J.' 1 0000-0002-7624-6045 
'Li, R.'   2 ?                   
'Lin, S.'  3 ?                   
'Long, L.' 4 ?                   
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Microb Cell Fact' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1475-2859 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            24 
_citation.language                  ? 
_citation.page_first                85 
_citation.page_last                 85 
_citation.title                     
;Biodegradation of p-nitrophenol by Rhodococcus sp. 21391 unveils a two-component p-nitrophenol monooxygenase with broad substrate specificity.
;
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1186/s12934-025-02712-1 
_citation.pdbx_database_id_PubMed   40247276 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Yang, J.' 1 ? 
primary 'Lin, S.'  2 ? 
primary 'Li, W.'   3 ? 
primary 'Wang, X.' 4 ? 
primary 'Li, R.'   5 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man '4-nitrophenol 4-monooxygenase/4-nitrocatechol 2-monooxygenase, oxygenase component' 60876.938 3   
1.14.13.166,1.14.13.29 ? ? 
;The sequence reference for Rhodococcus sp. 21391 (TAX ID 2683591), with the Genebank accession number WP_007295637, is not available in UniProt at the time of biocuration. Current sequence reference is from UniProt ID Q6F4M8.
;
2 water   nat water                                                                                18.015    122 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        '4-NP/4-NCA monooxygenase,PNP monooxygenase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MRTGQQYLESLRDGRQVYVGGELIDDVTTHPKTSGYAKAIAEYYDLHLDPEHQDVLTFVDDDGVRKSMHWFLPRSKADAA
RRRAYHEFWFRHFQGGIFTRPPAGMHVVMYAQIDDPEPWGDNAVVAGGRTISFADNIRSQWQRVTTDDVALSPMFVDVQF
DRGRDDALVETPMLSIVEQNDQGIVVRGWKAMGTSLPFVNELLVGNLWRPGQTSDQTVYAIVPVNTPGLSLVCRQSNATP
DADPYDHPLSTIGDELDGMAYFDDVFIPWENVQHIGNPDHAKWYPQRQFDWVHIETQIRHAVHAELIVGLALLLTNALGT
NNNPIVQSQLADLVRFRETCKAFAIAAEETGFTTAGGLFKPNNIYVDLGRAHYLENIHNAVNQLIEFCGRGVVMSPTKAD
FDHPFLGPKLEEALRGTSISARDRVSIFRQISERYLTQWGARHEMFEKFNGTPLYLVRLLTMQRTEYQVDGPLTDLARQV
LGFGDTEALAARAAEVEKNSNWASVAYQPEYAREQDVRDGYYKETEKVLEHHHHHH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MRTGQQYLESLRDGRQVYVGGELIDDVTTHPKTSGYAKAIAEYYDLHLDPEHQDVLTFVDDDGVRKSMHWFLPRSKADAA
RRRAYHEFWFRHFQGGIFTRPPAGMHVVMYAQIDDPEPWGDNAVVAGGRTISFADNIRSQWQRVTTDDVALSPMFVDVQF
DRGRDDALVETPMLSIVEQNDQGIVVRGWKAMGTSLPFVNELLVGNLWRPGQTSDQTVYAIVPVNTPGLSLVCRQSNATP
DADPYDHPLSTIGDELDGMAYFDDVFIPWENVQHIGNPDHAKWYPQRQFDWVHIETQIRHAVHAELIVGLALLLTNALGT
NNNPIVQSQLADLVRFRETCKAFAIAAEETGFTTAGGLFKPNNIYVDLGRAHYLENIHNAVNQLIEFCGRGVVMSPTKAD
FDHPFLGPKLEEALRGTSISARDRVSIFRQISERYLTQWGARHEMFEKFNGTPLYLVRLLTMQRTEYQVDGPLTDLARQV
LGFGDTEALAARAAEVEKNSNWASVAYQPEYAREQDVRDGYYKETEKVLEHHHHHH
;
_entity_poly.pdbx_strand_id                 A,B,C 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ARG n 
1 3   THR n 
1 4   GLY n 
1 5   GLN n 
1 6   GLN n 
1 7   TYR n 
1 8   LEU n 
1 9   GLU n 
1 10  SER n 
1 11  LEU n 
1 12  ARG n 
1 13  ASP n 
1 14  GLY n 
1 15  ARG n 
1 16  GLN n 
1 17  VAL n 
1 18  TYR n 
1 19  VAL n 
1 20  GLY n 
1 21  GLY n 
1 22  GLU n 
1 23  LEU n 
1 24  ILE n 
1 25  ASP n 
1 26  ASP n 
1 27  VAL n 
1 28  THR n 
1 29  THR n 
1 30  HIS n 
1 31  PRO n 
1 32  LYS n 
1 33  THR n 
1 34  SER n 
1 35  GLY n 
1 36  TYR n 
1 37  ALA n 
1 38  LYS n 
1 39  ALA n 
1 40  ILE n 
1 41  ALA n 
1 42  GLU n 
1 43  TYR n 
1 44  TYR n 
1 45  ASP n 
1 46  LEU n 
1 47  HIS n 
1 48  LEU n 
1 49  ASP n 
1 50  PRO n 
1 51  GLU n 
1 52  HIS n 
1 53  GLN n 
1 54  ASP n 
1 55  VAL n 
1 56  LEU n 
1 57  THR n 
1 58  PHE n 
1 59  VAL n 
1 60  ASP n 
1 61  ASP n 
1 62  ASP n 
1 63  GLY n 
1 64  VAL n 
1 65  ARG n 
1 66  LYS n 
1 67  SER n 
1 68  MET n 
1 69  HIS n 
1 70  TRP n 
1 71  PHE n 
1 72  LEU n 
1 73  PRO n 
1 74  ARG n 
1 75  SER n 
1 76  LYS n 
1 77  ALA n 
1 78  ASP n 
1 79  ALA n 
1 80  ALA n 
1 81  ARG n 
1 82  ARG n 
1 83  ARG n 
1 84  ALA n 
1 85  TYR n 
1 86  HIS n 
1 87  GLU n 
1 88  PHE n 
1 89  TRP n 
1 90  PHE n 
1 91  ARG n 
1 92  HIS n 
1 93  PHE n 
1 94  GLN n 
1 95  GLY n 
1 96  GLY n 
1 97  ILE n 
1 98  PHE n 
1 99  THR n 
1 100 ARG n 
1 101 PRO n 
1 102 PRO n 
1 103 ALA n 
1 104 GLY n 
1 105 MET n 
1 106 HIS n 
1 107 VAL n 
1 108 VAL n 
1 109 MET n 
1 110 TYR n 
1 111 ALA n 
1 112 GLN n 
1 113 ILE n 
1 114 ASP n 
1 115 ASP n 
1 116 PRO n 
1 117 GLU n 
1 118 PRO n 
1 119 TRP n 
1 120 GLY n 
1 121 ASP n 
1 122 ASN n 
1 123 ALA n 
1 124 VAL n 
1 125 VAL n 
1 126 ALA n 
1 127 GLY n 
1 128 GLY n 
1 129 ARG n 
1 130 THR n 
1 131 ILE n 
1 132 SER n 
1 133 PHE n 
1 134 ALA n 
1 135 ASP n 
1 136 ASN n 
1 137 ILE n 
1 138 ARG n 
1 139 SER n 
1 140 GLN n 
1 141 TRP n 
1 142 GLN n 
1 143 ARG n 
1 144 VAL n 
1 145 THR n 
1 146 THR n 
1 147 ASP n 
1 148 ASP n 
1 149 VAL n 
1 150 ALA n 
1 151 LEU n 
1 152 SER n 
1 153 PRO n 
1 154 MET n 
1 155 PHE n 
1 156 VAL n 
1 157 ASP n 
1 158 VAL n 
1 159 GLN n 
1 160 PHE n 
1 161 ASP n 
1 162 ARG n 
1 163 GLY n 
1 164 ARG n 
1 165 ASP n 
1 166 ASP n 
1 167 ALA n 
1 168 LEU n 
1 169 VAL n 
1 170 GLU n 
1 171 THR n 
1 172 PRO n 
1 173 MET n 
1 174 LEU n 
1 175 SER n 
1 176 ILE n 
1 177 VAL n 
1 178 GLU n 
1 179 GLN n 
1 180 ASN n 
1 181 ASP n 
1 182 GLN n 
1 183 GLY n 
1 184 ILE n 
1 185 VAL n 
1 186 VAL n 
1 187 ARG n 
1 188 GLY n 
1 189 TRP n 
1 190 LYS n 
1 191 ALA n 
1 192 MET n 
1 193 GLY n 
1 194 THR n 
1 195 SER n 
1 196 LEU n 
1 197 PRO n 
1 198 PHE n 
1 199 VAL n 
1 200 ASN n 
1 201 GLU n 
1 202 LEU n 
1 203 LEU n 
1 204 VAL n 
1 205 GLY n 
1 206 ASN n 
1 207 LEU n 
1 208 TRP n 
1 209 ARG n 
1 210 PRO n 
1 211 GLY n 
1 212 GLN n 
1 213 THR n 
1 214 SER n 
1 215 ASP n 
1 216 GLN n 
1 217 THR n 
1 218 VAL n 
1 219 TYR n 
1 220 ALA n 
1 221 ILE n 
1 222 VAL n 
1 223 PRO n 
1 224 VAL n 
1 225 ASN n 
1 226 THR n 
1 227 PRO n 
1 228 GLY n 
1 229 LEU n 
1 230 SER n 
1 231 LEU n 
1 232 VAL n 
1 233 CYS n 
1 234 ARG n 
1 235 GLN n 
1 236 SER n 
1 237 ASN n 
1 238 ALA n 
1 239 THR n 
1 240 PRO n 
1 241 ASP n 
1 242 ALA n 
1 243 ASP n 
1 244 PRO n 
1 245 TYR n 
1 246 ASP n 
1 247 HIS n 
1 248 PRO n 
1 249 LEU n 
1 250 SER n 
1 251 THR n 
1 252 ILE n 
1 253 GLY n 
1 254 ASP n 
1 255 GLU n 
1 256 LEU n 
1 257 ASP n 
1 258 GLY n 
1 259 MET n 
1 260 ALA n 
1 261 TYR n 
1 262 PHE n 
1 263 ASP n 
1 264 ASP n 
1 265 VAL n 
1 266 PHE n 
1 267 ILE n 
1 268 PRO n 
1 269 TRP n 
1 270 GLU n 
1 271 ASN n 
1 272 VAL n 
1 273 GLN n 
1 274 HIS n 
1 275 ILE n 
1 276 GLY n 
1 277 ASN n 
1 278 PRO n 
1 279 ASP n 
1 280 HIS n 
1 281 ALA n 
1 282 LYS n 
1 283 TRP n 
1 284 TYR n 
1 285 PRO n 
1 286 GLN n 
1 287 ARG n 
1 288 GLN n 
1 289 PHE n 
1 290 ASP n 
1 291 TRP n 
1 292 VAL n 
1 293 HIS n 
1 294 ILE n 
1 295 GLU n 
1 296 THR n 
1 297 GLN n 
1 298 ILE n 
1 299 ARG n 
1 300 HIS n 
1 301 ALA n 
1 302 VAL n 
1 303 HIS n 
1 304 ALA n 
1 305 GLU n 
1 306 LEU n 
1 307 ILE n 
1 308 VAL n 
1 309 GLY n 
1 310 LEU n 
1 311 ALA n 
1 312 LEU n 
1 313 LEU n 
1 314 LEU n 
1 315 THR n 
1 316 ASN n 
1 317 ALA n 
1 318 LEU n 
1 319 GLY n 
1 320 THR n 
1 321 ASN n 
1 322 ASN n 
1 323 ASN n 
1 324 PRO n 
1 325 ILE n 
1 326 VAL n 
1 327 GLN n 
1 328 SER n 
1 329 GLN n 
1 330 LEU n 
1 331 ALA n 
1 332 ASP n 
1 333 LEU n 
1 334 VAL n 
1 335 ARG n 
1 336 PHE n 
1 337 ARG n 
1 338 GLU n 
1 339 THR n 
1 340 CYS n 
1 341 LYS n 
1 342 ALA n 
1 343 PHE n 
1 344 ALA n 
1 345 ILE n 
1 346 ALA n 
1 347 ALA n 
1 348 GLU n 
1 349 GLU n 
1 350 THR n 
1 351 GLY n 
1 352 PHE n 
1 353 THR n 
1 354 THR n 
1 355 ALA n 
1 356 GLY n 
1 357 GLY n 
1 358 LEU n 
1 359 PHE n 
1 360 LYS n 
1 361 PRO n 
1 362 ASN n 
1 363 ASN n 
1 364 ILE n 
1 365 TYR n 
1 366 VAL n 
1 367 ASP n 
1 368 LEU n 
1 369 GLY n 
1 370 ARG n 
1 371 ALA n 
1 372 HIS n 
1 373 TYR n 
1 374 LEU n 
1 375 GLU n 
1 376 ASN n 
1 377 ILE n 
1 378 HIS n 
1 379 ASN n 
1 380 ALA n 
1 381 VAL n 
1 382 ASN n 
1 383 GLN n 
1 384 LEU n 
1 385 ILE n 
1 386 GLU n 
1 387 PHE n 
1 388 CYS n 
1 389 GLY n 
1 390 ARG n 
1 391 GLY n 
1 392 VAL n 
1 393 VAL n 
1 394 MET n 
1 395 SER n 
1 396 PRO n 
1 397 THR n 
1 398 LYS n 
1 399 ALA n 
1 400 ASP n 
1 401 PHE n 
1 402 ASP n 
1 403 HIS n 
1 404 PRO n 
1 405 PHE n 
1 406 LEU n 
1 407 GLY n 
1 408 PRO n 
1 409 LYS n 
1 410 LEU n 
1 411 GLU n 
1 412 GLU n 
1 413 ALA n 
1 414 LEU n 
1 415 ARG n 
1 416 GLY n 
1 417 THR n 
1 418 SER n 
1 419 ILE n 
1 420 SER n 
1 421 ALA n 
1 422 ARG n 
1 423 ASP n 
1 424 ARG n 
1 425 VAL n 
1 426 SER n 
1 427 ILE n 
1 428 PHE n 
1 429 ARG n 
1 430 GLN n 
1 431 ILE n 
1 432 SER n 
1 433 GLU n 
1 434 ARG n 
1 435 TYR n 
1 436 LEU n 
1 437 THR n 
1 438 GLN n 
1 439 TRP n 
1 440 GLY n 
1 441 ALA n 
1 442 ARG n 
1 443 HIS n 
1 444 GLU n 
1 445 MET n 
1 446 PHE n 
1 447 GLU n 
1 448 LYS n 
1 449 PHE n 
1 450 ASN n 
1 451 GLY n 
1 452 THR n 
1 453 PRO n 
1 454 LEU n 
1 455 TYR n 
1 456 LEU n 
1 457 VAL n 
1 458 ARG n 
1 459 LEU n 
1 460 LEU n 
1 461 THR n 
1 462 MET n 
1 463 GLN n 
1 464 ARG n 
1 465 THR n 
1 466 GLU n 
1 467 TYR n 
1 468 GLN n 
1 469 VAL n 
1 470 ASP n 
1 471 GLY n 
1 472 PRO n 
1 473 LEU n 
1 474 THR n 
1 475 ASP n 
1 476 LEU n 
1 477 ALA n 
1 478 ARG n 
1 479 GLN n 
1 480 VAL n 
1 481 LEU n 
1 482 GLY n 
1 483 PHE n 
1 484 GLY n 
1 485 ASP n 
1 486 THR n 
1 487 GLU n 
1 488 ALA n 
1 489 LEU n 
1 490 ALA n 
1 491 ALA n 
1 492 ARG n 
1 493 ALA n 
1 494 ALA n 
1 495 GLU n 
1 496 VAL n 
1 497 GLU n 
1 498 LYS n 
1 499 ASN n 
1 500 SER n 
1 501 ASN n 
1 502 TRP n 
1 503 ALA n 
1 504 SER n 
1 505 VAL n 
1 506 ALA n 
1 507 TYR n 
1 508 GLN n 
1 509 PRO n 
1 510 GLU n 
1 511 TYR n 
1 512 ALA n 
1 513 ARG n 
1 514 GLU n 
1 515 GLN n 
1 516 ASP n 
1 517 VAL n 
1 518 ARG n 
1 519 ASP n 
1 520 GLY n 
1 521 TYR n 
1 522 TYR n 
1 523 LYS n 
1 524 GLU n 
1 525 THR n 
1 526 GLU n 
1 527 LYS n 
1 528 VAL n 
1 529 LEU n 
1 530 GLU n 
1 531 HIS n 
1 532 HIS n 
1 533 HIS n 
1 534 HIS n 
1 535 HIS n 
1 536 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   536 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 npcA 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Rhodococcus sp. 21391' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2683591 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   1   MET MET A . n 
A 1 2   ARG 2   2   2   ARG ARG A . n 
A 1 3   THR 3   3   3   THR THR A . n 
A 1 4   GLY 4   4   4   GLY GLY A . n 
A 1 5   GLN 5   5   5   GLN GLN A . n 
A 1 6   GLN 6   6   6   GLN GLN A . n 
A 1 7   TYR 7   7   7   TYR TYR A . n 
A 1 8   LEU 8   8   8   LEU LEU A . n 
A 1 9   GLU 9   9   9   GLU GLU A . n 
A 1 10  SER 10  10  10  SER SER A . n 
A 1 11  LEU 11  11  11  LEU LEU A . n 
A 1 12  ARG 12  12  12  ARG ARG A . n 
A 1 13  ASP 13  13  13  ASP ASP A . n 
A 1 14  GLY 14  14  14  GLY GLY A . n 
A 1 15  ARG 15  15  15  ARG ARG A . n 
A 1 16  GLN 16  16  16  GLN GLN A . n 
A 1 17  VAL 17  17  17  VAL VAL A . n 
A 1 18  TYR 18  18  18  TYR TYR A . n 
A 1 19  VAL 19  19  19  VAL VAL A . n 
A 1 20  GLY 20  20  20  GLY GLY A . n 
A 1 21  GLY 21  21  21  GLY GLY A . n 
A 1 22  GLU 22  22  22  GLU GLU A . n 
A 1 23  LEU 23  23  23  LEU LEU A . n 
A 1 24  ILE 24  24  24  ILE ILE A . n 
A 1 25  ASP 25  25  25  ASP ASP A . n 
A 1 26  ASP 26  26  26  ASP ASP A . n 
A 1 27  VAL 27  27  27  VAL VAL A . n 
A 1 28  THR 28  28  28  THR THR A . n 
A 1 29  THR 29  29  29  THR THR A . n 
A 1 30  HIS 30  30  30  HIS HIS A . n 
A 1 31  PRO 31  31  31  PRO PRO A . n 
A 1 32  LYS 32  32  32  LYS LYS A . n 
A 1 33  THR 33  33  33  THR THR A . n 
A 1 34  SER 34  34  34  SER SER A . n 
A 1 35  GLY 35  35  35  GLY GLY A . n 
A 1 36  TYR 36  36  36  TYR TYR A . n 
A 1 37  ALA 37  37  37  ALA ALA A . n 
A 1 38  LYS 38  38  38  LYS LYS A . n 
A 1 39  ALA 39  39  39  ALA ALA A . n 
A 1 40  ILE 40  40  40  ILE ILE A . n 
A 1 41  ALA 41  41  41  ALA ALA A . n 
A 1 42  GLU 42  42  42  GLU GLU A . n 
A 1 43  TYR 43  43  43  TYR TYR A . n 
A 1 44  TYR 44  44  44  TYR TYR A . n 
A 1 45  ASP 45  45  45  ASP ASP A . n 
A 1 46  LEU 46  46  46  LEU LEU A . n 
A 1 47  HIS 47  47  47  HIS HIS A . n 
A 1 48  LEU 48  48  48  LEU LEU A . n 
A 1 49  ASP 49  49  49  ASP ASP A . n 
A 1 50  PRO 50  50  50  PRO PRO A . n 
A 1 51  GLU 51  51  51  GLU GLU A . n 
A 1 52  HIS 52  52  52  HIS HIS A . n 
A 1 53  GLN 53  53  53  GLN GLN A . n 
A 1 54  ASP 54  54  54  ASP ASP A . n 
A 1 55  VAL 55  55  55  VAL VAL A . n 
A 1 56  LEU 56  56  56  LEU LEU A . n 
A 1 57  THR 57  57  57  THR THR A . n 
A 1 58  PHE 58  58  58  PHE PHE A . n 
A 1 59  VAL 59  59  59  VAL VAL A . n 
A 1 60  ASP 60  60  60  ASP ASP A . n 
A 1 61  ASP 61  61  61  ASP ASP A . n 
A 1 62  ASP 62  62  62  ASP ASP A . n 
A 1 63  GLY 63  63  63  GLY GLY A . n 
A 1 64  VAL 64  64  64  VAL VAL A . n 
A 1 65  ARG 65  65  65  ARG ARG A . n 
A 1 66  LYS 66  66  66  LYS LYS A . n 
A 1 67  SER 67  67  67  SER SER A . n 
A 1 68  MET 68  68  68  MET MET A . n 
A 1 69  HIS 69  69  69  HIS HIS A . n 
A 1 70  TRP 70  70  70  TRP TRP A . n 
A 1 71  PHE 71  71  71  PHE PHE A . n 
A 1 72  LEU 72  72  72  LEU LEU A . n 
A 1 73  PRO 73  73  73  PRO PRO A . n 
A 1 74  ARG 74  74  74  ARG ARG A . n 
A 1 75  SER 75  75  75  SER SER A . n 
A 1 76  LYS 76  76  76  LYS LYS A . n 
A 1 77  ALA 77  77  77  ALA ALA A . n 
A 1 78  ASP 78  78  78  ASP ASP A . n 
A 1 79  ALA 79  79  79  ALA ALA A . n 
A 1 80  ALA 80  80  80  ALA ALA A . n 
A 1 81  ARG 81  81  81  ARG ARG A . n 
A 1 82  ARG 82  82  82  ARG ARG A . n 
A 1 83  ARG 83  83  83  ARG ARG A . n 
A 1 84  ALA 84  84  84  ALA ALA A . n 
A 1 85  TYR 85  85  85  TYR TYR A . n 
A 1 86  HIS 86  86  86  HIS HIS A . n 
A 1 87  GLU 87  87  87  GLU GLU A . n 
A 1 88  PHE 88  88  88  PHE PHE A . n 
A 1 89  TRP 89  89  89  TRP TRP A . n 
A 1 90  PHE 90  90  90  PHE PHE A . n 
A 1 91  ARG 91  91  91  ARG ARG A . n 
A 1 92  HIS 92  92  92  HIS HIS A . n 
A 1 93  PHE 93  93  93  PHE PHE A . n 
A 1 94  GLN 94  94  94  GLN GLN A . n 
A 1 95  GLY 95  95  95  GLY GLY A . n 
A 1 96  GLY 96  96  96  GLY GLY A . n 
A 1 97  ILE 97  97  97  ILE ILE A . n 
A 1 98  PHE 98  98  98  PHE PHE A . n 
A 1 99  THR 99  99  99  THR THR A . n 
A 1 100 ARG 100 100 100 ARG ARG A . n 
A 1 101 PRO 101 101 101 PRO PRO A . n 
A 1 102 PRO 102 102 102 PRO PRO A . n 
A 1 103 ALA 103 103 103 ALA ALA A . n 
A 1 104 GLY 104 104 104 GLY GLY A . n 
A 1 105 MET 105 105 105 MET MET A . n 
A 1 106 HIS 106 106 106 HIS HIS A . n 
A 1 107 VAL 107 107 107 VAL VAL A . n 
A 1 108 VAL 108 108 108 VAL VAL A . n 
A 1 109 MET 109 109 109 MET MET A . n 
A 1 110 TYR 110 110 110 TYR TYR A . n 
A 1 111 ALA 111 111 111 ALA ALA A . n 
A 1 112 GLN 112 112 112 GLN GLN A . n 
A 1 113 ILE 113 113 113 ILE ILE A . n 
A 1 114 ASP 114 114 114 ASP ASP A . n 
A 1 115 ASP 115 115 115 ASP ASP A . n 
A 1 116 PRO 116 116 116 PRO PRO A . n 
A 1 117 GLU 117 117 117 GLU GLU A . n 
A 1 118 PRO 118 118 118 PRO PRO A . n 
A 1 119 TRP 119 119 119 TRP TRP A . n 
A 1 120 GLY 120 120 120 GLY GLY A . n 
A 1 121 ASP 121 121 121 ASP ASP A . n 
A 1 122 ASN 122 122 122 ASN ASN A . n 
A 1 123 ALA 123 123 123 ALA ALA A . n 
A 1 124 VAL 124 124 124 VAL VAL A . n 
A 1 125 VAL 125 125 125 VAL VAL A . n 
A 1 126 ALA 126 126 126 ALA ALA A . n 
A 1 127 GLY 127 127 127 GLY GLY A . n 
A 1 128 GLY 128 128 128 GLY GLY A . n 
A 1 129 ARG 129 129 129 ARG ARG A . n 
A 1 130 THR 130 130 130 THR THR A . n 
A 1 131 ILE 131 131 131 ILE ILE A . n 
A 1 132 SER 132 132 132 SER SER A . n 
A 1 133 PHE 133 133 133 PHE PHE A . n 
A 1 134 ALA 134 134 134 ALA ALA A . n 
A 1 135 ASP 135 135 135 ASP ASP A . n 
A 1 136 ASN 136 136 136 ASN ASN A . n 
A 1 137 ILE 137 137 137 ILE ILE A . n 
A 1 138 ARG 138 138 138 ARG ARG A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 GLN 140 140 140 GLN GLN A . n 
A 1 141 TRP 141 141 141 TRP TRP A . n 
A 1 142 GLN 142 142 142 GLN GLN A . n 
A 1 143 ARG 143 143 143 ARG ARG A . n 
A 1 144 VAL 144 144 144 VAL VAL A . n 
A 1 145 THR 145 145 145 THR THR A . n 
A 1 146 THR 146 146 146 THR THR A . n 
A 1 147 ASP 147 147 147 ASP ASP A . n 
A 1 148 ASP 148 148 148 ASP ASP A . n 
A 1 149 VAL 149 149 149 VAL VAL A . n 
A 1 150 ALA 150 150 150 ALA ALA A . n 
A 1 151 LEU 151 151 151 LEU LEU A . n 
A 1 152 SER 152 152 152 SER SER A . n 
A 1 153 PRO 153 153 153 PRO PRO A . n 
A 1 154 MET 154 154 154 MET MET A . n 
A 1 155 PHE 155 155 155 PHE PHE A . n 
A 1 156 VAL 156 156 156 VAL VAL A . n 
A 1 157 ASP 157 157 157 ASP ASP A . n 
A 1 158 VAL 158 158 158 VAL VAL A . n 
A 1 159 GLN 159 159 159 GLN GLN A . n 
A 1 160 PHE 160 160 160 PHE PHE A . n 
A 1 161 ASP 161 161 ?   ?   ?   A . n 
A 1 162 ARG 162 162 ?   ?   ?   A . n 
A 1 163 GLY 163 163 ?   ?   ?   A . n 
A 1 164 ARG 164 164 ?   ?   ?   A . n 
A 1 165 ASP 165 165 ?   ?   ?   A . n 
A 1 166 ASP 166 166 ?   ?   ?   A . n 
A 1 167 ALA 167 167 ?   ?   ?   A . n 
A 1 168 LEU 168 168 ?   ?   ?   A . n 
A 1 169 VAL 169 169 ?   ?   ?   A . n 
A 1 170 GLU 170 170 170 GLU GLU A . n 
A 1 171 THR 171 171 171 THR THR A . n 
A 1 172 PRO 172 172 172 PRO PRO A . n 
A 1 173 MET 173 173 173 MET MET A . n 
A 1 174 LEU 174 174 174 LEU LEU A . n 
A 1 175 SER 175 175 175 SER SER A . n 
A 1 176 ILE 176 176 176 ILE ILE A . n 
A 1 177 VAL 177 177 177 VAL VAL A . n 
A 1 178 GLU 178 178 178 GLU GLU A . n 
A 1 179 GLN 179 179 179 GLN GLN A . n 
A 1 180 ASN 180 180 180 ASN ASN A . n 
A 1 181 ASP 181 181 181 ASP ASP A . n 
A 1 182 GLN 182 182 182 GLN GLN A . n 
A 1 183 GLY 183 183 183 GLY GLY A . n 
A 1 184 ILE 184 184 184 ILE ILE A . n 
A 1 185 VAL 185 185 185 VAL VAL A . n 
A 1 186 VAL 186 186 186 VAL VAL A . n 
A 1 187 ARG 187 187 187 ARG ARG A . n 
A 1 188 GLY 188 188 188 GLY GLY A . n 
A 1 189 TRP 189 189 189 TRP TRP A . n 
A 1 190 LYS 190 190 190 LYS LYS A . n 
A 1 191 ALA 191 191 191 ALA ALA A . n 
A 1 192 MET 192 192 192 MET MET A . n 
A 1 193 GLY 193 193 193 GLY GLY A . n 
A 1 194 THR 194 194 194 THR THR A . n 
A 1 195 SER 195 195 195 SER SER A . n 
A 1 196 LEU 196 196 196 LEU LEU A . n 
A 1 197 PRO 197 197 197 PRO PRO A . n 
A 1 198 PHE 198 198 198 PHE PHE A . n 
A 1 199 VAL 199 199 199 VAL VAL A . n 
A 1 200 ASN 200 200 200 ASN ASN A . n 
A 1 201 GLU 201 201 201 GLU GLU A . n 
A 1 202 LEU 202 202 202 LEU LEU A . n 
A 1 203 LEU 203 203 203 LEU LEU A . n 
A 1 204 VAL 204 204 204 VAL VAL A . n 
A 1 205 GLY 205 205 205 GLY GLY A . n 
A 1 206 ASN 206 206 206 ASN ASN A . n 
A 1 207 LEU 207 207 207 LEU LEU A . n 
A 1 208 TRP 208 208 208 TRP TRP A . n 
A 1 209 ARG 209 209 209 ARG ARG A . n 
A 1 210 PRO 210 210 210 PRO PRO A . n 
A 1 211 GLY 211 211 211 GLY GLY A . n 
A 1 212 GLN 212 212 212 GLN GLN A . n 
A 1 213 THR 213 213 213 THR THR A . n 
A 1 214 SER 214 214 214 SER SER A . n 
A 1 215 ASP 215 215 215 ASP ASP A . n 
A 1 216 GLN 216 216 216 GLN GLN A . n 
A 1 217 THR 217 217 217 THR THR A . n 
A 1 218 VAL 218 218 218 VAL VAL A . n 
A 1 219 TYR 219 219 219 TYR TYR A . n 
A 1 220 ALA 220 220 220 ALA ALA A . n 
A 1 221 ILE 221 221 221 ILE ILE A . n 
A 1 222 VAL 222 222 222 VAL VAL A . n 
A 1 223 PRO 223 223 223 PRO PRO A . n 
A 1 224 VAL 224 224 224 VAL VAL A . n 
A 1 225 ASN 225 225 225 ASN ASN A . n 
A 1 226 THR 226 226 226 THR THR A . n 
A 1 227 PRO 227 227 227 PRO PRO A . n 
A 1 228 GLY 228 228 228 GLY GLY A . n 
A 1 229 LEU 229 229 229 LEU LEU A . n 
A 1 230 SER 230 230 230 SER SER A . n 
A 1 231 LEU 231 231 231 LEU LEU A . n 
A 1 232 VAL 232 232 232 VAL VAL A . n 
A 1 233 CYS 233 233 233 CYS CYS A . n 
A 1 234 ARG 234 234 234 ARG ARG A . n 
A 1 235 GLN 235 235 235 GLN GLN A . n 
A 1 236 SER 236 236 236 SER SER A . n 
A 1 237 ASN 237 237 237 ASN ASN A . n 
A 1 238 ALA 238 238 238 ALA ALA A . n 
A 1 239 THR 239 239 239 THR THR A . n 
A 1 240 PRO 240 240 240 PRO PRO A . n 
A 1 241 ASP 241 241 241 ASP ASP A . n 
A 1 242 ALA 242 242 242 ALA ALA A . n 
A 1 243 ASP 243 243 243 ASP ASP A . n 
A 1 244 PRO 244 244 244 PRO PRO A . n 
A 1 245 TYR 245 245 245 TYR TYR A . n 
A 1 246 ASP 246 246 246 ASP ASP A . n 
A 1 247 HIS 247 247 247 HIS HIS A . n 
A 1 248 PRO 248 248 248 PRO PRO A . n 
A 1 249 LEU 249 249 249 LEU LEU A . n 
A 1 250 SER 250 250 250 SER SER A . n 
A 1 251 THR 251 251 251 THR THR A . n 
A 1 252 ILE 252 252 252 ILE ILE A . n 
A 1 253 GLY 253 253 253 GLY GLY A . n 
A 1 254 ASP 254 254 254 ASP ASP A . n 
A 1 255 GLU 255 255 255 GLU GLU A . n 
A 1 256 LEU 256 256 256 LEU LEU A . n 
A 1 257 ASP 257 257 257 ASP ASP A . n 
A 1 258 GLY 258 258 258 GLY GLY A . n 
A 1 259 MET 259 259 259 MET MET A . n 
A 1 260 ALA 260 260 260 ALA ALA A . n 
A 1 261 TYR 261 261 261 TYR TYR A . n 
A 1 262 PHE 262 262 262 PHE PHE A . n 
A 1 263 ASP 263 263 263 ASP ASP A . n 
A 1 264 ASP 264 264 264 ASP ASP A . n 
A 1 265 VAL 265 265 265 VAL VAL A . n 
A 1 266 PHE 266 266 266 PHE PHE A . n 
A 1 267 ILE 267 267 267 ILE ILE A . n 
A 1 268 PRO 268 268 268 PRO PRO A . n 
A 1 269 TRP 269 269 269 TRP TRP A . n 
A 1 270 GLU 270 270 270 GLU GLU A . n 
A 1 271 ASN 271 271 271 ASN ASN A . n 
A 1 272 VAL 272 272 272 VAL VAL A . n 
A 1 273 GLN 273 273 273 GLN GLN A . n 
A 1 274 HIS 274 274 274 HIS HIS A . n 
A 1 275 ILE 275 275 275 ILE ILE A . n 
A 1 276 GLY 276 276 276 GLY GLY A . n 
A 1 277 ASN 277 277 277 ASN ASN A . n 
A 1 278 PRO 278 278 278 PRO PRO A . n 
A 1 279 ASP 279 279 279 ASP ASP A . n 
A 1 280 HIS 280 280 280 HIS HIS A . n 
A 1 281 ALA 281 281 281 ALA ALA A . n 
A 1 282 LYS 282 282 282 LYS LYS A . n 
A 1 283 TRP 283 283 283 TRP TRP A . n 
A 1 284 TYR 284 284 284 TYR TYR A . n 
A 1 285 PRO 285 285 285 PRO PRO A . n 
A 1 286 GLN 286 286 286 GLN GLN A . n 
A 1 287 ARG 287 287 287 ARG ARG A . n 
A 1 288 GLN 288 288 288 GLN GLN A . n 
A 1 289 PHE 289 289 289 PHE PHE A . n 
A 1 290 ASP 290 290 290 ASP ASP A . n 
A 1 291 TRP 291 291 291 TRP TRP A . n 
A 1 292 VAL 292 292 292 VAL VAL A . n 
A 1 293 HIS 293 293 293 HIS HIS A . n 
A 1 294 ILE 294 294 294 ILE ILE A . n 
A 1 295 GLU 295 295 295 GLU GLU A . n 
A 1 296 THR 296 296 296 THR THR A . n 
A 1 297 GLN 297 297 297 GLN GLN A . n 
A 1 298 ILE 298 298 298 ILE ILE A . n 
A 1 299 ARG 299 299 299 ARG ARG A . n 
A 1 300 HIS 300 300 300 HIS HIS A . n 
A 1 301 ALA 301 301 301 ALA ALA A . n 
A 1 302 VAL 302 302 302 VAL VAL A . n 
A 1 303 HIS 303 303 303 HIS HIS A . n 
A 1 304 ALA 304 304 304 ALA ALA A . n 
A 1 305 GLU 305 305 305 GLU GLU A . n 
A 1 306 LEU 306 306 306 LEU LEU A . n 
A 1 307 ILE 307 307 307 ILE ILE A . n 
A 1 308 VAL 308 308 308 VAL VAL A . n 
A 1 309 GLY 309 309 309 GLY GLY A . n 
A 1 310 LEU 310 310 310 LEU LEU A . n 
A 1 311 ALA 311 311 311 ALA ALA A . n 
A 1 312 LEU 312 312 312 LEU LEU A . n 
A 1 313 LEU 313 313 313 LEU LEU A . n 
A 1 314 LEU 314 314 314 LEU LEU A . n 
A 1 315 THR 315 315 315 THR THR A . n 
A 1 316 ASN 316 316 316 ASN ASN A . n 
A 1 317 ALA 317 317 317 ALA ALA A . n 
A 1 318 LEU 318 318 318 LEU LEU A . n 
A 1 319 GLY 319 319 319 GLY GLY A . n 
A 1 320 THR 320 320 320 THR THR A . n 
A 1 321 ASN 321 321 321 ASN ASN A . n 
A 1 322 ASN 322 322 322 ASN ASN A . n 
A 1 323 ASN 323 323 323 ASN ASN A . n 
A 1 324 PRO 324 324 324 PRO PRO A . n 
A 1 325 ILE 325 325 325 ILE ILE A . n 
A 1 326 VAL 326 326 326 VAL VAL A . n 
A 1 327 GLN 327 327 327 GLN GLN A . n 
A 1 328 SER 328 328 328 SER SER A . n 
A 1 329 GLN 329 329 329 GLN GLN A . n 
A 1 330 LEU 330 330 330 LEU LEU A . n 
A 1 331 ALA 331 331 331 ALA ALA A . n 
A 1 332 ASP 332 332 332 ASP ASP A . n 
A 1 333 LEU 333 333 333 LEU LEU A . n 
A 1 334 VAL 334 334 334 VAL VAL A . n 
A 1 335 ARG 335 335 335 ARG ARG A . n 
A 1 336 PHE 336 336 336 PHE PHE A . n 
A 1 337 ARG 337 337 337 ARG ARG A . n 
A 1 338 GLU 338 338 338 GLU GLU A . n 
A 1 339 THR 339 339 339 THR THR A . n 
A 1 340 CYS 340 340 340 CYS CYS A . n 
A 1 341 LYS 341 341 341 LYS LYS A . n 
A 1 342 ALA 342 342 342 ALA ALA A . n 
A 1 343 PHE 343 343 343 PHE PHE A . n 
A 1 344 ALA 344 344 344 ALA ALA A . n 
A 1 345 ILE 345 345 345 ILE ILE A . n 
A 1 346 ALA 346 346 346 ALA ALA A . n 
A 1 347 ALA 347 347 347 ALA ALA A . n 
A 1 348 GLU 348 348 348 GLU GLU A . n 
A 1 349 GLU 349 349 349 GLU GLU A . n 
A 1 350 THR 350 350 350 THR THR A . n 
A 1 351 GLY 351 351 351 GLY GLY A . n 
A 1 352 PHE 352 352 352 PHE PHE A . n 
A 1 353 THR 353 353 353 THR THR A . n 
A 1 354 THR 354 354 354 THR THR A . n 
A 1 355 ALA 355 355 355 ALA ALA A . n 
A 1 356 GLY 356 356 356 GLY GLY A . n 
A 1 357 GLY 357 357 357 GLY GLY A . n 
A 1 358 LEU 358 358 358 LEU LEU A . n 
A 1 359 PHE 359 359 359 PHE PHE A . n 
A 1 360 LYS 360 360 360 LYS LYS A . n 
A 1 361 PRO 361 361 361 PRO PRO A . n 
A 1 362 ASN 362 362 362 ASN ASN A . n 
A 1 363 ASN 363 363 363 ASN ASN A . n 
A 1 364 ILE 364 364 364 ILE ILE A . n 
A 1 365 TYR 365 365 365 TYR TYR A . n 
A 1 366 VAL 366 366 366 VAL VAL A . n 
A 1 367 ASP 367 367 367 ASP ASP A . n 
A 1 368 LEU 368 368 368 LEU LEU A . n 
A 1 369 GLY 369 369 369 GLY GLY A . n 
A 1 370 ARG 370 370 370 ARG ARG A . n 
A 1 371 ALA 371 371 371 ALA ALA A . n 
A 1 372 HIS 372 372 372 HIS HIS A . n 
A 1 373 TYR 373 373 373 TYR TYR A . n 
A 1 374 LEU 374 374 374 LEU LEU A . n 
A 1 375 GLU 375 375 375 GLU GLU A . n 
A 1 376 ASN 376 376 376 ASN ASN A . n 
A 1 377 ILE 377 377 377 ILE ILE A . n 
A 1 378 HIS 378 378 378 HIS HIS A . n 
A 1 379 ASN 379 379 379 ASN ASN A . n 
A 1 380 ALA 380 380 380 ALA ALA A . n 
A 1 381 VAL 381 381 381 VAL VAL A . n 
A 1 382 ASN 382 382 382 ASN ASN A . n 
A 1 383 GLN 383 383 383 GLN GLN A . n 
A 1 384 LEU 384 384 384 LEU LEU A . n 
A 1 385 ILE 385 385 385 ILE ILE A . n 
A 1 386 GLU 386 386 386 GLU GLU A . n 
A 1 387 PHE 387 387 387 PHE PHE A . n 
A 1 388 CYS 388 388 388 CYS CYS A . n 
A 1 389 GLY 389 389 389 GLY GLY A . n 
A 1 390 ARG 390 390 390 ARG ARG A . n 
A 1 391 GLY 391 391 391 GLY GLY A . n 
A 1 392 VAL 392 392 392 VAL VAL A . n 
A 1 393 VAL 393 393 393 VAL VAL A . n 
A 1 394 MET 394 394 394 MET MET A . n 
A 1 395 SER 395 395 395 SER SER A . n 
A 1 396 PRO 396 396 396 PRO PRO A . n 
A 1 397 THR 397 397 397 THR THR A . n 
A 1 398 LYS 398 398 398 LYS LYS A . n 
A 1 399 ALA 399 399 399 ALA ALA A . n 
A 1 400 ASP 400 400 400 ASP ASP A . n 
A 1 401 PHE 401 401 401 PHE PHE A . n 
A 1 402 ASP 402 402 402 ASP ASP A . n 
A 1 403 HIS 403 403 403 HIS HIS A . n 
A 1 404 PRO 404 404 404 PRO PRO A . n 
A 1 405 PHE 405 405 405 PHE PHE A . n 
A 1 406 LEU 406 406 406 LEU LEU A . n 
A 1 407 GLY 407 407 407 GLY GLY A . n 
A 1 408 PRO 408 408 408 PRO PRO A . n 
A 1 409 LYS 409 409 409 LYS LYS A . n 
A 1 410 LEU 410 410 410 LEU LEU A . n 
A 1 411 GLU 411 411 411 GLU GLU A . n 
A 1 412 GLU 412 412 412 GLU GLU A . n 
A 1 413 ALA 413 413 413 ALA ALA A . n 
A 1 414 LEU 414 414 414 LEU LEU A . n 
A 1 415 ARG 415 415 415 ARG ARG A . n 
A 1 416 GLY 416 416 416 GLY GLY A . n 
A 1 417 THR 417 417 417 THR THR A . n 
A 1 418 SER 418 418 418 SER SER A . n 
A 1 419 ILE 419 419 419 ILE ILE A . n 
A 1 420 SER 420 420 420 SER SER A . n 
A 1 421 ALA 421 421 421 ALA ALA A . n 
A 1 422 ARG 422 422 422 ARG ARG A . n 
A 1 423 ASP 423 423 423 ASP ASP A . n 
A 1 424 ARG 424 424 424 ARG ARG A . n 
A 1 425 VAL 425 425 425 VAL VAL A . n 
A 1 426 SER 426 426 426 SER SER A . n 
A 1 427 ILE 427 427 427 ILE ILE A . n 
A 1 428 PHE 428 428 428 PHE PHE A . n 
A 1 429 ARG 429 429 429 ARG ARG A . n 
A 1 430 GLN 430 430 430 GLN GLN A . n 
A 1 431 ILE 431 431 431 ILE ILE A . n 
A 1 432 SER 432 432 432 SER SER A . n 
A 1 433 GLU 433 433 433 GLU GLU A . n 
A 1 434 ARG 434 434 434 ARG ARG A . n 
A 1 435 TYR 435 435 435 TYR TYR A . n 
A 1 436 LEU 436 436 436 LEU LEU A . n 
A 1 437 THR 437 437 437 THR THR A . n 
A 1 438 GLN 438 438 438 GLN GLN A . n 
A 1 439 TRP 439 439 439 TRP TRP A . n 
A 1 440 GLY 440 440 440 GLY GLY A . n 
A 1 441 ALA 441 441 441 ALA ALA A . n 
A 1 442 ARG 442 442 442 ARG ARG A . n 
A 1 443 HIS 443 443 443 HIS HIS A . n 
A 1 444 GLU 444 444 444 GLU GLU A . n 
A 1 445 MET 445 445 445 MET MET A . n 
A 1 446 PHE 446 446 446 PHE PHE A . n 
A 1 447 GLU 447 447 447 GLU GLU A . n 
A 1 448 LYS 448 448 448 LYS LYS A . n 
A 1 449 PHE 449 449 449 PHE PHE A . n 
A 1 450 ASN 450 450 450 ASN ASN A . n 
A 1 451 GLY 451 451 451 GLY GLY A . n 
A 1 452 THR 452 452 452 THR THR A . n 
A 1 453 PRO 453 453 453 PRO PRO A . n 
A 1 454 LEU 454 454 454 LEU LEU A . n 
A 1 455 TYR 455 455 455 TYR TYR A . n 
A 1 456 LEU 456 456 456 LEU LEU A . n 
A 1 457 VAL 457 457 457 VAL VAL A . n 
A 1 458 ARG 458 458 458 ARG ARG A . n 
A 1 459 LEU 459 459 459 LEU LEU A . n 
A 1 460 LEU 460 460 460 LEU LEU A . n 
A 1 461 THR 461 461 461 THR THR A . n 
A 1 462 MET 462 462 462 MET MET A . n 
A 1 463 GLN 463 463 463 GLN GLN A . n 
A 1 464 ARG 464 464 464 ARG ARG A . n 
A 1 465 THR 465 465 465 THR THR A . n 
A 1 466 GLU 466 466 466 GLU GLU A . n 
A 1 467 TYR 467 467 467 TYR TYR A . n 
A 1 468 GLN 468 468 468 GLN GLN A . n 
A 1 469 VAL 469 469 469 VAL VAL A . n 
A 1 470 ASP 470 470 470 ASP ASP A . n 
A 1 471 GLY 471 471 471 GLY GLY A . n 
A 1 472 PRO 472 472 472 PRO PRO A . n 
A 1 473 LEU 473 473 473 LEU LEU A . n 
A 1 474 THR 474 474 474 THR THR A . n 
A 1 475 ASP 475 475 475 ASP ASP A . n 
A 1 476 LEU 476 476 476 LEU LEU A . n 
A 1 477 ALA 477 477 477 ALA ALA A . n 
A 1 478 ARG 478 478 478 ARG ARG A . n 
A 1 479 GLN 479 479 479 GLN GLN A . n 
A 1 480 VAL 480 480 480 VAL VAL A . n 
A 1 481 LEU 481 481 481 LEU LEU A . n 
A 1 482 GLY 482 482 482 GLY GLY A . n 
A 1 483 PHE 483 483 483 PHE PHE A . n 
A 1 484 GLY 484 484 484 GLY GLY A . n 
A 1 485 ASP 485 485 485 ASP ASP A . n 
A 1 486 THR 486 486 486 THR THR A . n 
A 1 487 GLU 487 487 487 GLU GLU A . n 
A 1 488 ALA 488 488 488 ALA ALA A . n 
A 1 489 LEU 489 489 489 LEU LEU A . n 
A 1 490 ALA 490 490 490 ALA ALA A . n 
A 1 491 ALA 491 491 491 ALA ALA A . n 
A 1 492 ARG 492 492 492 ARG ARG A . n 
A 1 493 ALA 493 493 493 ALA ALA A . n 
A 1 494 ALA 494 494 494 ALA ALA A . n 
A 1 495 GLU 495 495 495 GLU GLU A . n 
A 1 496 VAL 496 496 496 VAL VAL A . n 
A 1 497 GLU 497 497 497 GLU GLU A . n 
A 1 498 LYS 498 498 498 LYS LYS A . n 
A 1 499 ASN 499 499 499 ASN ASN A . n 
A 1 500 SER 500 500 500 SER SER A . n 
A 1 501 ASN 501 501 501 ASN ASN A . n 
A 1 502 TRP 502 502 502 TRP TRP A . n 
A 1 503 ALA 503 503 ?   ?   ?   A . n 
A 1 504 SER 504 504 ?   ?   ?   A . n 
A 1 505 VAL 505 505 ?   ?   ?   A . n 
A 1 506 ALA 506 506 ?   ?   ?   A . n 
A 1 507 TYR 507 507 ?   ?   ?   A . n 
A 1 508 GLN 508 508 ?   ?   ?   A . n 
A 1 509 PRO 509 509 ?   ?   ?   A . n 
A 1 510 GLU 510 510 ?   ?   ?   A . n 
A 1 511 TYR 511 511 ?   ?   ?   A . n 
A 1 512 ALA 512 512 ?   ?   ?   A . n 
A 1 513 ARG 513 513 ?   ?   ?   A . n 
A 1 514 GLU 514 514 ?   ?   ?   A . n 
A 1 515 GLN 515 515 ?   ?   ?   A . n 
A 1 516 ASP 516 516 ?   ?   ?   A . n 
A 1 517 VAL 517 517 ?   ?   ?   A . n 
A 1 518 ARG 518 518 ?   ?   ?   A . n 
A 1 519 ASP 519 519 ?   ?   ?   A . n 
A 1 520 GLY 520 520 ?   ?   ?   A . n 
A 1 521 TYR 521 521 ?   ?   ?   A . n 
A 1 522 TYR 522 522 ?   ?   ?   A . n 
A 1 523 LYS 523 523 ?   ?   ?   A . n 
A 1 524 GLU 524 524 ?   ?   ?   A . n 
A 1 525 THR 525 525 ?   ?   ?   A . n 
A 1 526 GLU 526 526 ?   ?   ?   A . n 
A 1 527 LYS 527 527 ?   ?   ?   A . n 
A 1 528 VAL 528 528 ?   ?   ?   A . n 
A 1 529 LEU 529 529 ?   ?   ?   A . n 
A 1 530 GLU 530 530 ?   ?   ?   A . n 
A 1 531 HIS 531 531 ?   ?   ?   A . n 
A 1 532 HIS 532 532 ?   ?   ?   A . n 
A 1 533 HIS 533 533 ?   ?   ?   A . n 
A 1 534 HIS 534 534 ?   ?   ?   A . n 
A 1 535 HIS 535 535 ?   ?   ?   A . n 
A 1 536 HIS 536 536 ?   ?   ?   A . n 
B 1 1   MET 1   1   1   MET MET B . n 
B 1 2   ARG 2   2   2   ARG ARG B . n 
B 1 3   THR 3   3   3   THR THR B . n 
B 1 4   GLY 4   4   4   GLY GLY B . n 
B 1 5   GLN 5   5   5   GLN GLN B . n 
B 1 6   GLN 6   6   6   GLN GLN B . n 
B 1 7   TYR 7   7   7   TYR TYR B . n 
B 1 8   LEU 8   8   8   LEU LEU B . n 
B 1 9   GLU 9   9   9   GLU GLU B . n 
B 1 10  SER 10  10  10  SER SER B . n 
B 1 11  LEU 11  11  11  LEU LEU B . n 
B 1 12  ARG 12  12  12  ARG ARG B . n 
B 1 13  ASP 13  13  13  ASP ASP B . n 
B 1 14  GLY 14  14  14  GLY GLY B . n 
B 1 15  ARG 15  15  15  ARG ARG B . n 
B 1 16  GLN 16  16  16  GLN GLN B . n 
B 1 17  VAL 17  17  17  VAL VAL B . n 
B 1 18  TYR 18  18  18  TYR TYR B . n 
B 1 19  VAL 19  19  19  VAL VAL B . n 
B 1 20  GLY 20  20  20  GLY GLY B . n 
B 1 21  GLY 21  21  21  GLY GLY B . n 
B 1 22  GLU 22  22  22  GLU GLU B . n 
B 1 23  LEU 23  23  23  LEU LEU B . n 
B 1 24  ILE 24  24  24  ILE ILE B . n 
B 1 25  ASP 25  25  25  ASP ASP B . n 
B 1 26  ASP 26  26  26  ASP ASP B . n 
B 1 27  VAL 27  27  27  VAL VAL B . n 
B 1 28  THR 28  28  28  THR THR B . n 
B 1 29  THR 29  29  29  THR THR B . n 
B 1 30  HIS 30  30  30  HIS HIS B . n 
B 1 31  PRO 31  31  31  PRO PRO B . n 
B 1 32  LYS 32  32  32  LYS LYS B . n 
B 1 33  THR 33  33  33  THR THR B . n 
B 1 34  SER 34  34  34  SER SER B . n 
B 1 35  GLY 35  35  35  GLY GLY B . n 
B 1 36  TYR 36  36  36  TYR TYR B . n 
B 1 37  ALA 37  37  37  ALA ALA B . n 
B 1 38  LYS 38  38  38  LYS LYS B . n 
B 1 39  ALA 39  39  39  ALA ALA B . n 
B 1 40  ILE 40  40  40  ILE ILE B . n 
B 1 41  ALA 41  41  41  ALA ALA B . n 
B 1 42  GLU 42  42  42  GLU GLU B . n 
B 1 43  TYR 43  43  43  TYR TYR B . n 
B 1 44  TYR 44  44  44  TYR TYR B . n 
B 1 45  ASP 45  45  45  ASP ASP B . n 
B 1 46  LEU 46  46  46  LEU LEU B . n 
B 1 47  HIS 47  47  47  HIS HIS B . n 
B 1 48  LEU 48  48  48  LEU LEU B . n 
B 1 49  ASP 49  49  49  ASP ASP B . n 
B 1 50  PRO 50  50  50  PRO PRO B . n 
B 1 51  GLU 51  51  51  GLU GLU B . n 
B 1 52  HIS 52  52  52  HIS HIS B . n 
B 1 53  GLN 53  53  53  GLN GLN B . n 
B 1 54  ASP 54  54  54  ASP ASP B . n 
B 1 55  VAL 55  55  55  VAL VAL B . n 
B 1 56  LEU 56  56  56  LEU LEU B . n 
B 1 57  THR 57  57  57  THR THR B . n 
B 1 58  PHE 58  58  58  PHE PHE B . n 
B 1 59  VAL 59  59  59  VAL VAL B . n 
B 1 60  ASP 60  60  60  ASP ASP B . n 
B 1 61  ASP 61  61  61  ASP ASP B . n 
B 1 62  ASP 62  62  62  ASP ASP B . n 
B 1 63  GLY 63  63  63  GLY GLY B . n 
B 1 64  VAL 64  64  64  VAL VAL B . n 
B 1 65  ARG 65  65  65  ARG ARG B . n 
B 1 66  LYS 66  66  66  LYS LYS B . n 
B 1 67  SER 67  67  67  SER SER B . n 
B 1 68  MET 68  68  68  MET MET B . n 
B 1 69  HIS 69  69  69  HIS HIS B . n 
B 1 70  TRP 70  70  70  TRP TRP B . n 
B 1 71  PHE 71  71  71  PHE PHE B . n 
B 1 72  LEU 72  72  72  LEU LEU B . n 
B 1 73  PRO 73  73  73  PRO PRO B . n 
B 1 74  ARG 74  74  74  ARG ARG B . n 
B 1 75  SER 75  75  75  SER SER B . n 
B 1 76  LYS 76  76  76  LYS LYS B . n 
B 1 77  ALA 77  77  77  ALA ALA B . n 
B 1 78  ASP 78  78  78  ASP ASP B . n 
B 1 79  ALA 79  79  79  ALA ALA B . n 
B 1 80  ALA 80  80  80  ALA ALA B . n 
B 1 81  ARG 81  81  81  ARG ARG B . n 
B 1 82  ARG 82  82  82  ARG ARG B . n 
B 1 83  ARG 83  83  83  ARG ARG B . n 
B 1 84  ALA 84  84  84  ALA ALA B . n 
B 1 85  TYR 85  85  85  TYR TYR B . n 
B 1 86  HIS 86  86  86  HIS HIS B . n 
B 1 87  GLU 87  87  87  GLU GLU B . n 
B 1 88  PHE 88  88  88  PHE PHE B . n 
B 1 89  TRP 89  89  89  TRP TRP B . n 
B 1 90  PHE 90  90  90  PHE PHE B . n 
B 1 91  ARG 91  91  91  ARG ARG B . n 
B 1 92  HIS 92  92  92  HIS HIS B . n 
B 1 93  PHE 93  93  93  PHE PHE B . n 
B 1 94  GLN 94  94  94  GLN GLN B . n 
B 1 95  GLY 95  95  95  GLY GLY B . n 
B 1 96  GLY 96  96  96  GLY GLY B . n 
B 1 97  ILE 97  97  97  ILE ILE B . n 
B 1 98  PHE 98  98  98  PHE PHE B . n 
B 1 99  THR 99  99  99  THR THR B . n 
B 1 100 ARG 100 100 100 ARG ARG B . n 
B 1 101 PRO 101 101 101 PRO PRO B . n 
B 1 102 PRO 102 102 102 PRO PRO B . n 
B 1 103 ALA 103 103 103 ALA ALA B . n 
B 1 104 GLY 104 104 104 GLY GLY B . n 
B 1 105 MET 105 105 105 MET MET B . n 
B 1 106 HIS 106 106 106 HIS HIS B . n 
B 1 107 VAL 107 107 107 VAL VAL B . n 
B 1 108 VAL 108 108 108 VAL VAL B . n 
B 1 109 MET 109 109 109 MET MET B . n 
B 1 110 TYR 110 110 110 TYR TYR B . n 
B 1 111 ALA 111 111 111 ALA ALA B . n 
B 1 112 GLN 112 112 112 GLN GLN B . n 
B 1 113 ILE 113 113 113 ILE ILE B . n 
B 1 114 ASP 114 114 114 ASP ASP B . n 
B 1 115 ASP 115 115 115 ASP ASP B . n 
B 1 116 PRO 116 116 116 PRO PRO B . n 
B 1 117 GLU 117 117 117 GLU GLU B . n 
B 1 118 PRO 118 118 118 PRO PRO B . n 
B 1 119 TRP 119 119 119 TRP TRP B . n 
B 1 120 GLY 120 120 120 GLY GLY B . n 
B 1 121 ASP 121 121 121 ASP ASP B . n 
B 1 122 ASN 122 122 122 ASN ASN B . n 
B 1 123 ALA 123 123 123 ALA ALA B . n 
B 1 124 VAL 124 124 124 VAL VAL B . n 
B 1 125 VAL 125 125 125 VAL VAL B . n 
B 1 126 ALA 126 126 126 ALA ALA B . n 
B 1 127 GLY 127 127 127 GLY GLY B . n 
B 1 128 GLY 128 128 128 GLY GLY B . n 
B 1 129 ARG 129 129 129 ARG ARG B . n 
B 1 130 THR 130 130 130 THR THR B . n 
B 1 131 ILE 131 131 131 ILE ILE B . n 
B 1 132 SER 132 132 132 SER SER B . n 
B 1 133 PHE 133 133 133 PHE PHE B . n 
B 1 134 ALA 134 134 134 ALA ALA B . n 
B 1 135 ASP 135 135 135 ASP ASP B . n 
B 1 136 ASN 136 136 136 ASN ASN B . n 
B 1 137 ILE 137 137 137 ILE ILE B . n 
B 1 138 ARG 138 138 138 ARG ARG B . n 
B 1 139 SER 139 139 139 SER SER B . n 
B 1 140 GLN 140 140 140 GLN GLN B . n 
B 1 141 TRP 141 141 141 TRP TRP B . n 
B 1 142 GLN 142 142 142 GLN GLN B . n 
B 1 143 ARG 143 143 143 ARG ARG B . n 
B 1 144 VAL 144 144 144 VAL VAL B . n 
B 1 145 THR 145 145 145 THR THR B . n 
B 1 146 THR 146 146 146 THR THR B . n 
B 1 147 ASP 147 147 147 ASP ASP B . n 
B 1 148 ASP 148 148 148 ASP ASP B . n 
B 1 149 VAL 149 149 149 VAL VAL B . n 
B 1 150 ALA 150 150 150 ALA ALA B . n 
B 1 151 LEU 151 151 151 LEU LEU B . n 
B 1 152 SER 152 152 152 SER SER B . n 
B 1 153 PRO 153 153 153 PRO PRO B . n 
B 1 154 MET 154 154 154 MET MET B . n 
B 1 155 PHE 155 155 155 PHE PHE B . n 
B 1 156 VAL 156 156 156 VAL VAL B . n 
B 1 157 ASP 157 157 157 ASP ASP B . n 
B 1 158 VAL 158 158 158 VAL VAL B . n 
B 1 159 GLN 159 159 159 GLN GLN B . n 
B 1 160 PHE 160 160 160 PHE PHE B . n 
B 1 161 ASP 161 161 ?   ?   ?   B . n 
B 1 162 ARG 162 162 ?   ?   ?   B . n 
B 1 163 GLY 163 163 ?   ?   ?   B . n 
B 1 164 ARG 164 164 ?   ?   ?   B . n 
B 1 165 ASP 165 165 ?   ?   ?   B . n 
B 1 166 ASP 166 166 ?   ?   ?   B . n 
B 1 167 ALA 167 167 ?   ?   ?   B . n 
B 1 168 LEU 168 168 ?   ?   ?   B . n 
B 1 169 VAL 169 169 ?   ?   ?   B . n 
B 1 170 GLU 170 170 170 GLU GLU B . n 
B 1 171 THR 171 171 171 THR THR B . n 
B 1 172 PRO 172 172 172 PRO PRO B . n 
B 1 173 MET 173 173 173 MET MET B . n 
B 1 174 LEU 174 174 174 LEU LEU B . n 
B 1 175 SER 175 175 175 SER SER B . n 
B 1 176 ILE 176 176 176 ILE ILE B . n 
B 1 177 VAL 177 177 177 VAL VAL B . n 
B 1 178 GLU 178 178 178 GLU GLU B . n 
B 1 179 GLN 179 179 179 GLN GLN B . n 
B 1 180 ASN 180 180 180 ASN ASN B . n 
B 1 181 ASP 181 181 181 ASP ASP B . n 
B 1 182 GLN 182 182 182 GLN GLN B . n 
B 1 183 GLY 183 183 183 GLY GLY B . n 
B 1 184 ILE 184 184 184 ILE ILE B . n 
B 1 185 VAL 185 185 185 VAL VAL B . n 
B 1 186 VAL 186 186 186 VAL VAL B . n 
B 1 187 ARG 187 187 187 ARG ARG B . n 
B 1 188 GLY 188 188 188 GLY GLY B . n 
B 1 189 TRP 189 189 189 TRP TRP B . n 
B 1 190 LYS 190 190 190 LYS LYS B . n 
B 1 191 ALA 191 191 191 ALA ALA B . n 
B 1 192 MET 192 192 192 MET MET B . n 
B 1 193 GLY 193 193 193 GLY GLY B . n 
B 1 194 THR 194 194 194 THR THR B . n 
B 1 195 SER 195 195 195 SER SER B . n 
B 1 196 LEU 196 196 196 LEU LEU B . n 
B 1 197 PRO 197 197 197 PRO PRO B . n 
B 1 198 PHE 198 198 198 PHE PHE B . n 
B 1 199 VAL 199 199 199 VAL VAL B . n 
B 1 200 ASN 200 200 200 ASN ASN B . n 
B 1 201 GLU 201 201 201 GLU GLU B . n 
B 1 202 LEU 202 202 202 LEU LEU B . n 
B 1 203 LEU 203 203 203 LEU LEU B . n 
B 1 204 VAL 204 204 204 VAL VAL B . n 
B 1 205 GLY 205 205 205 GLY GLY B . n 
B 1 206 ASN 206 206 206 ASN ASN B . n 
B 1 207 LEU 207 207 207 LEU LEU B . n 
B 1 208 TRP 208 208 208 TRP TRP B . n 
B 1 209 ARG 209 209 209 ARG ARG B . n 
B 1 210 PRO 210 210 210 PRO PRO B . n 
B 1 211 GLY 211 211 211 GLY GLY B . n 
B 1 212 GLN 212 212 212 GLN GLN B . n 
B 1 213 THR 213 213 213 THR THR B . n 
B 1 214 SER 214 214 214 SER SER B . n 
B 1 215 ASP 215 215 215 ASP ASP B . n 
B 1 216 GLN 216 216 216 GLN GLN B . n 
B 1 217 THR 217 217 217 THR THR B . n 
B 1 218 VAL 218 218 218 VAL VAL B . n 
B 1 219 TYR 219 219 219 TYR TYR B . n 
B 1 220 ALA 220 220 220 ALA ALA B . n 
B 1 221 ILE 221 221 221 ILE ILE B . n 
B 1 222 VAL 222 222 222 VAL VAL B . n 
B 1 223 PRO 223 223 223 PRO PRO B . n 
B 1 224 VAL 224 224 224 VAL VAL B . n 
B 1 225 ASN 225 225 225 ASN ASN B . n 
B 1 226 THR 226 226 226 THR THR B . n 
B 1 227 PRO 227 227 227 PRO PRO B . n 
B 1 228 GLY 228 228 228 GLY GLY B . n 
B 1 229 LEU 229 229 229 LEU LEU B . n 
B 1 230 SER 230 230 230 SER SER B . n 
B 1 231 LEU 231 231 231 LEU LEU B . n 
B 1 232 VAL 232 232 232 VAL VAL B . n 
B 1 233 CYS 233 233 233 CYS CYS B . n 
B 1 234 ARG 234 234 234 ARG ARG B . n 
B 1 235 GLN 235 235 235 GLN GLN B . n 
B 1 236 SER 236 236 236 SER SER B . n 
B 1 237 ASN 237 237 237 ASN ASN B . n 
B 1 238 ALA 238 238 238 ALA ALA B . n 
B 1 239 THR 239 239 239 THR THR B . n 
B 1 240 PRO 240 240 240 PRO PRO B . n 
B 1 241 ASP 241 241 241 ASP ASP B . n 
B 1 242 ALA 242 242 242 ALA ALA B . n 
B 1 243 ASP 243 243 243 ASP ASP B . n 
B 1 244 PRO 244 244 244 PRO PRO B . n 
B 1 245 TYR 245 245 245 TYR TYR B . n 
B 1 246 ASP 246 246 246 ASP ASP B . n 
B 1 247 HIS 247 247 247 HIS HIS B . n 
B 1 248 PRO 248 248 248 PRO PRO B . n 
B 1 249 LEU 249 249 249 LEU LEU B . n 
B 1 250 SER 250 250 250 SER SER B . n 
B 1 251 THR 251 251 251 THR THR B . n 
B 1 252 ILE 252 252 252 ILE ILE B . n 
B 1 253 GLY 253 253 253 GLY GLY B . n 
B 1 254 ASP 254 254 254 ASP ASP B . n 
B 1 255 GLU 255 255 255 GLU GLU B . n 
B 1 256 LEU 256 256 256 LEU LEU B . n 
B 1 257 ASP 257 257 257 ASP ASP B . n 
B 1 258 GLY 258 258 258 GLY GLY B . n 
B 1 259 MET 259 259 259 MET MET B . n 
B 1 260 ALA 260 260 260 ALA ALA B . n 
B 1 261 TYR 261 261 261 TYR TYR B . n 
B 1 262 PHE 262 262 262 PHE PHE B . n 
B 1 263 ASP 263 263 263 ASP ASP B . n 
B 1 264 ASP 264 264 264 ASP ASP B . n 
B 1 265 VAL 265 265 265 VAL VAL B . n 
B 1 266 PHE 266 266 266 PHE PHE B . n 
B 1 267 ILE 267 267 267 ILE ILE B . n 
B 1 268 PRO 268 268 268 PRO PRO B . n 
B 1 269 TRP 269 269 269 TRP TRP B . n 
B 1 270 GLU 270 270 270 GLU GLU B . n 
B 1 271 ASN 271 271 271 ASN ASN B . n 
B 1 272 VAL 272 272 272 VAL VAL B . n 
B 1 273 GLN 273 273 273 GLN GLN B . n 
B 1 274 HIS 274 274 274 HIS HIS B . n 
B 1 275 ILE 275 275 275 ILE ILE B . n 
B 1 276 GLY 276 276 276 GLY GLY B . n 
B 1 277 ASN 277 277 277 ASN ASN B . n 
B 1 278 PRO 278 278 278 PRO PRO B . n 
B 1 279 ASP 279 279 279 ASP ASP B . n 
B 1 280 HIS 280 280 280 HIS HIS B . n 
B 1 281 ALA 281 281 281 ALA ALA B . n 
B 1 282 LYS 282 282 282 LYS LYS B . n 
B 1 283 TRP 283 283 283 TRP TRP B . n 
B 1 284 TYR 284 284 284 TYR TYR B . n 
B 1 285 PRO 285 285 285 PRO PRO B . n 
B 1 286 GLN 286 286 286 GLN GLN B . n 
B 1 287 ARG 287 287 287 ARG ARG B . n 
B 1 288 GLN 288 288 288 GLN GLN B . n 
B 1 289 PHE 289 289 289 PHE PHE B . n 
B 1 290 ASP 290 290 290 ASP ASP B . n 
B 1 291 TRP 291 291 291 TRP TRP B . n 
B 1 292 VAL 292 292 292 VAL VAL B . n 
B 1 293 HIS 293 293 293 HIS HIS B . n 
B 1 294 ILE 294 294 294 ILE ILE B . n 
B 1 295 GLU 295 295 295 GLU GLU B . n 
B 1 296 THR 296 296 296 THR THR B . n 
B 1 297 GLN 297 297 297 GLN GLN B . n 
B 1 298 ILE 298 298 298 ILE ILE B . n 
B 1 299 ARG 299 299 299 ARG ARG B . n 
B 1 300 HIS 300 300 300 HIS HIS B . n 
B 1 301 ALA 301 301 301 ALA ALA B . n 
B 1 302 VAL 302 302 302 VAL VAL B . n 
B 1 303 HIS 303 303 303 HIS HIS B . n 
B 1 304 ALA 304 304 304 ALA ALA B . n 
B 1 305 GLU 305 305 305 GLU GLU B . n 
B 1 306 LEU 306 306 306 LEU LEU B . n 
B 1 307 ILE 307 307 307 ILE ILE B . n 
B 1 308 VAL 308 308 308 VAL VAL B . n 
B 1 309 GLY 309 309 309 GLY GLY B . n 
B 1 310 LEU 310 310 310 LEU LEU B . n 
B 1 311 ALA 311 311 311 ALA ALA B . n 
B 1 312 LEU 312 312 312 LEU LEU B . n 
B 1 313 LEU 313 313 313 LEU LEU B . n 
B 1 314 LEU 314 314 314 LEU LEU B . n 
B 1 315 THR 315 315 315 THR THR B . n 
B 1 316 ASN 316 316 316 ASN ASN B . n 
B 1 317 ALA 317 317 317 ALA ALA B . n 
B 1 318 LEU 318 318 318 LEU LEU B . n 
B 1 319 GLY 319 319 319 GLY GLY B . n 
B 1 320 THR 320 320 320 THR THR B . n 
B 1 321 ASN 321 321 321 ASN ASN B . n 
B 1 322 ASN 322 322 322 ASN ASN B . n 
B 1 323 ASN 323 323 323 ASN ASN B . n 
B 1 324 PRO 324 324 324 PRO PRO B . n 
B 1 325 ILE 325 325 325 ILE ILE B . n 
B 1 326 VAL 326 326 326 VAL VAL B . n 
B 1 327 GLN 327 327 327 GLN GLN B . n 
B 1 328 SER 328 328 328 SER SER B . n 
B 1 329 GLN 329 329 329 GLN GLN B . n 
B 1 330 LEU 330 330 330 LEU LEU B . n 
B 1 331 ALA 331 331 331 ALA ALA B . n 
B 1 332 ASP 332 332 332 ASP ASP B . n 
B 1 333 LEU 333 333 333 LEU LEU B . n 
B 1 334 VAL 334 334 334 VAL VAL B . n 
B 1 335 ARG 335 335 335 ARG ARG B . n 
B 1 336 PHE 336 336 336 PHE PHE B . n 
B 1 337 ARG 337 337 337 ARG ARG B . n 
B 1 338 GLU 338 338 338 GLU GLU B . n 
B 1 339 THR 339 339 339 THR THR B . n 
B 1 340 CYS 340 340 340 CYS CYS B . n 
B 1 341 LYS 341 341 341 LYS LYS B . n 
B 1 342 ALA 342 342 342 ALA ALA B . n 
B 1 343 PHE 343 343 343 PHE PHE B . n 
B 1 344 ALA 344 344 344 ALA ALA B . n 
B 1 345 ILE 345 345 345 ILE ILE B . n 
B 1 346 ALA 346 346 346 ALA ALA B . n 
B 1 347 ALA 347 347 347 ALA ALA B . n 
B 1 348 GLU 348 348 348 GLU GLU B . n 
B 1 349 GLU 349 349 349 GLU GLU B . n 
B 1 350 THR 350 350 350 THR THR B . n 
B 1 351 GLY 351 351 351 GLY GLY B . n 
B 1 352 PHE 352 352 352 PHE PHE B . n 
B 1 353 THR 353 353 353 THR THR B . n 
B 1 354 THR 354 354 354 THR THR B . n 
B 1 355 ALA 355 355 355 ALA ALA B . n 
B 1 356 GLY 356 356 356 GLY GLY B . n 
B 1 357 GLY 357 357 357 GLY GLY B . n 
B 1 358 LEU 358 358 358 LEU LEU B . n 
B 1 359 PHE 359 359 359 PHE PHE B . n 
B 1 360 LYS 360 360 360 LYS LYS B . n 
B 1 361 PRO 361 361 361 PRO PRO B . n 
B 1 362 ASN 362 362 362 ASN ASN B . n 
B 1 363 ASN 363 363 363 ASN ASN B . n 
B 1 364 ILE 364 364 364 ILE ILE B . n 
B 1 365 TYR 365 365 365 TYR TYR B . n 
B 1 366 VAL 366 366 366 VAL VAL B . n 
B 1 367 ASP 367 367 367 ASP ASP B . n 
B 1 368 LEU 368 368 368 LEU LEU B . n 
B 1 369 GLY 369 369 369 GLY GLY B . n 
B 1 370 ARG 370 370 370 ARG ARG B . n 
B 1 371 ALA 371 371 371 ALA ALA B . n 
B 1 372 HIS 372 372 372 HIS HIS B . n 
B 1 373 TYR 373 373 373 TYR TYR B . n 
B 1 374 LEU 374 374 374 LEU LEU B . n 
B 1 375 GLU 375 375 375 GLU GLU B . n 
B 1 376 ASN 376 376 376 ASN ASN B . n 
B 1 377 ILE 377 377 377 ILE ILE B . n 
B 1 378 HIS 378 378 378 HIS HIS B . n 
B 1 379 ASN 379 379 379 ASN ASN B . n 
B 1 380 ALA 380 380 380 ALA ALA B . n 
B 1 381 VAL 381 381 381 VAL VAL B . n 
B 1 382 ASN 382 382 382 ASN ASN B . n 
B 1 383 GLN 383 383 383 GLN GLN B . n 
B 1 384 LEU 384 384 384 LEU LEU B . n 
B 1 385 ILE 385 385 385 ILE ILE B . n 
B 1 386 GLU 386 386 386 GLU GLU B . n 
B 1 387 PHE 387 387 387 PHE PHE B . n 
B 1 388 CYS 388 388 388 CYS CYS B . n 
B 1 389 GLY 389 389 389 GLY GLY B . n 
B 1 390 ARG 390 390 390 ARG ARG B . n 
B 1 391 GLY 391 391 391 GLY GLY B . n 
B 1 392 VAL 392 392 392 VAL VAL B . n 
B 1 393 VAL 393 393 393 VAL VAL B . n 
B 1 394 MET 394 394 394 MET MET B . n 
B 1 395 SER 395 395 395 SER SER B . n 
B 1 396 PRO 396 396 396 PRO PRO B . n 
B 1 397 THR 397 397 397 THR THR B . n 
B 1 398 LYS 398 398 398 LYS LYS B . n 
B 1 399 ALA 399 399 399 ALA ALA B . n 
B 1 400 ASP 400 400 400 ASP ASP B . n 
B 1 401 PHE 401 401 401 PHE PHE B . n 
B 1 402 ASP 402 402 402 ASP ASP B . n 
B 1 403 HIS 403 403 403 HIS HIS B . n 
B 1 404 PRO 404 404 404 PRO PRO B . n 
B 1 405 PHE 405 405 405 PHE PHE B . n 
B 1 406 LEU 406 406 406 LEU LEU B . n 
B 1 407 GLY 407 407 407 GLY GLY B . n 
B 1 408 PRO 408 408 408 PRO PRO B . n 
B 1 409 LYS 409 409 409 LYS LYS B . n 
B 1 410 LEU 410 410 410 LEU LEU B . n 
B 1 411 GLU 411 411 411 GLU GLU B . n 
B 1 412 GLU 412 412 412 GLU GLU B . n 
B 1 413 ALA 413 413 413 ALA ALA B . n 
B 1 414 LEU 414 414 414 LEU LEU B . n 
B 1 415 ARG 415 415 415 ARG ARG B . n 
B 1 416 GLY 416 416 416 GLY GLY B . n 
B 1 417 THR 417 417 417 THR THR B . n 
B 1 418 SER 418 418 418 SER SER B . n 
B 1 419 ILE 419 419 419 ILE ILE B . n 
B 1 420 SER 420 420 420 SER SER B . n 
B 1 421 ALA 421 421 421 ALA ALA B . n 
B 1 422 ARG 422 422 422 ARG ARG B . n 
B 1 423 ASP 423 423 423 ASP ASP B . n 
B 1 424 ARG 424 424 424 ARG ARG B . n 
B 1 425 VAL 425 425 425 VAL VAL B . n 
B 1 426 SER 426 426 426 SER SER B . n 
B 1 427 ILE 427 427 427 ILE ILE B . n 
B 1 428 PHE 428 428 428 PHE PHE B . n 
B 1 429 ARG 429 429 429 ARG ARG B . n 
B 1 430 GLN 430 430 430 GLN GLN B . n 
B 1 431 ILE 431 431 431 ILE ILE B . n 
B 1 432 SER 432 432 432 SER SER B . n 
B 1 433 GLU 433 433 433 GLU GLU B . n 
B 1 434 ARG 434 434 434 ARG ARG B . n 
B 1 435 TYR 435 435 435 TYR TYR B . n 
B 1 436 LEU 436 436 436 LEU LEU B . n 
B 1 437 THR 437 437 437 THR THR B . n 
B 1 438 GLN 438 438 438 GLN GLN B . n 
B 1 439 TRP 439 439 439 TRP TRP B . n 
B 1 440 GLY 440 440 440 GLY GLY B . n 
B 1 441 ALA 441 441 441 ALA ALA B . n 
B 1 442 ARG 442 442 442 ARG ARG B . n 
B 1 443 HIS 443 443 443 HIS HIS B . n 
B 1 444 GLU 444 444 444 GLU GLU B . n 
B 1 445 MET 445 445 445 MET MET B . n 
B 1 446 PHE 446 446 446 PHE PHE B . n 
B 1 447 GLU 447 447 447 GLU GLU B . n 
B 1 448 LYS 448 448 448 LYS LYS B . n 
B 1 449 PHE 449 449 449 PHE PHE B . n 
B 1 450 ASN 450 450 450 ASN ASN B . n 
B 1 451 GLY 451 451 451 GLY GLY B . n 
B 1 452 THR 452 452 452 THR THR B . n 
B 1 453 PRO 453 453 453 PRO PRO B . n 
B 1 454 LEU 454 454 454 LEU LEU B . n 
B 1 455 TYR 455 455 455 TYR TYR B . n 
B 1 456 LEU 456 456 456 LEU LEU B . n 
B 1 457 VAL 457 457 457 VAL VAL B . n 
B 1 458 ARG 458 458 458 ARG ARG B . n 
B 1 459 LEU 459 459 459 LEU LEU B . n 
B 1 460 LEU 460 460 460 LEU LEU B . n 
B 1 461 THR 461 461 461 THR THR B . n 
B 1 462 MET 462 462 462 MET MET B . n 
B 1 463 GLN 463 463 463 GLN GLN B . n 
B 1 464 ARG 464 464 464 ARG ARG B . n 
B 1 465 THR 465 465 465 THR THR B . n 
B 1 466 GLU 466 466 466 GLU GLU B . n 
B 1 467 TYR 467 467 467 TYR TYR B . n 
B 1 468 GLN 468 468 468 GLN GLN B . n 
B 1 469 VAL 469 469 469 VAL VAL B . n 
B 1 470 ASP 470 470 470 ASP ASP B . n 
B 1 471 GLY 471 471 471 GLY GLY B . n 
B 1 472 PRO 472 472 472 PRO PRO B . n 
B 1 473 LEU 473 473 473 LEU LEU B . n 
B 1 474 THR 474 474 474 THR THR B . n 
B 1 475 ASP 475 475 475 ASP ASP B . n 
B 1 476 LEU 476 476 476 LEU LEU B . n 
B 1 477 ALA 477 477 477 ALA ALA B . n 
B 1 478 ARG 478 478 478 ARG ARG B . n 
B 1 479 GLN 479 479 479 GLN GLN B . n 
B 1 480 VAL 480 480 480 VAL VAL B . n 
B 1 481 LEU 481 481 481 LEU LEU B . n 
B 1 482 GLY 482 482 482 GLY GLY B . n 
B 1 483 PHE 483 483 483 PHE PHE B . n 
B 1 484 GLY 484 484 484 GLY GLY B . n 
B 1 485 ASP 485 485 485 ASP ASP B . n 
B 1 486 THR 486 486 486 THR THR B . n 
B 1 487 GLU 487 487 487 GLU GLU B . n 
B 1 488 ALA 488 488 488 ALA ALA B . n 
B 1 489 LEU 489 489 489 LEU LEU B . n 
B 1 490 ALA 490 490 490 ALA ALA B . n 
B 1 491 ALA 491 491 491 ALA ALA B . n 
B 1 492 ARG 492 492 492 ARG ARG B . n 
B 1 493 ALA 493 493 493 ALA ALA B . n 
B 1 494 ALA 494 494 494 ALA ALA B . n 
B 1 495 GLU 495 495 495 GLU GLU B . n 
B 1 496 VAL 496 496 496 VAL VAL B . n 
B 1 497 GLU 497 497 497 GLU GLU B . n 
B 1 498 LYS 498 498 498 LYS LYS B . n 
B 1 499 ASN 499 499 499 ASN ASN B . n 
B 1 500 SER 500 500 500 SER SER B . n 
B 1 501 ASN 501 501 ?   ?   ?   B . n 
B 1 502 TRP 502 502 ?   ?   ?   B . n 
B 1 503 ALA 503 503 ?   ?   ?   B . n 
B 1 504 SER 504 504 ?   ?   ?   B . n 
B 1 505 VAL 505 505 ?   ?   ?   B . n 
B 1 506 ALA 506 506 ?   ?   ?   B . n 
B 1 507 TYR 507 507 ?   ?   ?   B . n 
B 1 508 GLN 508 508 ?   ?   ?   B . n 
B 1 509 PRO 509 509 ?   ?   ?   B . n 
B 1 510 GLU 510 510 ?   ?   ?   B . n 
B 1 511 TYR 511 511 ?   ?   ?   B . n 
B 1 512 ALA 512 512 ?   ?   ?   B . n 
B 1 513 ARG 513 513 ?   ?   ?   B . n 
B 1 514 GLU 514 514 ?   ?   ?   B . n 
B 1 515 GLN 515 515 ?   ?   ?   B . n 
B 1 516 ASP 516 516 ?   ?   ?   B . n 
B 1 517 VAL 517 517 ?   ?   ?   B . n 
B 1 518 ARG 518 518 ?   ?   ?   B . n 
B 1 519 ASP 519 519 ?   ?   ?   B . n 
B 1 520 GLY 520 520 ?   ?   ?   B . n 
B 1 521 TYR 521 521 ?   ?   ?   B . n 
B 1 522 TYR 522 522 ?   ?   ?   B . n 
B 1 523 LYS 523 523 ?   ?   ?   B . n 
B 1 524 GLU 524 524 ?   ?   ?   B . n 
B 1 525 THR 525 525 ?   ?   ?   B . n 
B 1 526 GLU 526 526 ?   ?   ?   B . n 
B 1 527 LYS 527 527 ?   ?   ?   B . n 
B 1 528 VAL 528 528 ?   ?   ?   B . n 
B 1 529 LEU 529 529 ?   ?   ?   B . n 
B 1 530 GLU 530 530 ?   ?   ?   B . n 
B 1 531 HIS 531 531 ?   ?   ?   B . n 
B 1 532 HIS 532 532 ?   ?   ?   B . n 
B 1 533 HIS 533 533 ?   ?   ?   B . n 
B 1 534 HIS 534 534 ?   ?   ?   B . n 
B 1 535 HIS 535 535 ?   ?   ?   B . n 
B 1 536 HIS 536 536 ?   ?   ?   B . n 
C 1 1   MET 1   1   1   MET MET C . n 
C 1 2   ARG 2   2   2   ARG ARG C . n 
C 1 3   THR 3   3   3   THR THR C . n 
C 1 4   GLY 4   4   4   GLY GLY C . n 
C 1 5   GLN 5   5   5   GLN GLN C . n 
C 1 6   GLN 6   6   6   GLN GLN C . n 
C 1 7   TYR 7   7   7   TYR TYR C . n 
C 1 8   LEU 8   8   8   LEU LEU C . n 
C 1 9   GLU 9   9   9   GLU GLU C . n 
C 1 10  SER 10  10  10  SER SER C . n 
C 1 11  LEU 11  11  11  LEU LEU C . n 
C 1 12  ARG 12  12  12  ARG ARG C . n 
C 1 13  ASP 13  13  13  ASP ASP C . n 
C 1 14  GLY 14  14  14  GLY GLY C . n 
C 1 15  ARG 15  15  15  ARG ARG C . n 
C 1 16  GLN 16  16  16  GLN GLN C . n 
C 1 17  VAL 17  17  17  VAL VAL C . n 
C 1 18  TYR 18  18  18  TYR TYR C . n 
C 1 19  VAL 19  19  19  VAL VAL C . n 
C 1 20  GLY 20  20  20  GLY GLY C . n 
C 1 21  GLY 21  21  21  GLY GLY C . n 
C 1 22  GLU 22  22  22  GLU GLU C . n 
C 1 23  LEU 23  23  23  LEU LEU C . n 
C 1 24  ILE 24  24  24  ILE ILE C . n 
C 1 25  ASP 25  25  25  ASP ASP C . n 
C 1 26  ASP 26  26  26  ASP ASP C . n 
C 1 27  VAL 27  27  27  VAL VAL C . n 
C 1 28  THR 28  28  28  THR THR C . n 
C 1 29  THR 29  29  29  THR THR C . n 
C 1 30  HIS 30  30  30  HIS HIS C . n 
C 1 31  PRO 31  31  31  PRO PRO C . n 
C 1 32  LYS 32  32  32  LYS LYS C . n 
C 1 33  THR 33  33  33  THR THR C . n 
C 1 34  SER 34  34  34  SER SER C . n 
C 1 35  GLY 35  35  35  GLY GLY C . n 
C 1 36  TYR 36  36  36  TYR TYR C . n 
C 1 37  ALA 37  37  37  ALA ALA C . n 
C 1 38  LYS 38  38  38  LYS LYS C . n 
C 1 39  ALA 39  39  39  ALA ALA C . n 
C 1 40  ILE 40  40  40  ILE ILE C . n 
C 1 41  ALA 41  41  41  ALA ALA C . n 
C 1 42  GLU 42  42  42  GLU GLU C . n 
C 1 43  TYR 43  43  43  TYR TYR C . n 
C 1 44  TYR 44  44  44  TYR TYR C . n 
C 1 45  ASP 45  45  45  ASP ASP C . n 
C 1 46  LEU 46  46  46  LEU LEU C . n 
C 1 47  HIS 47  47  47  HIS HIS C . n 
C 1 48  LEU 48  48  48  LEU LEU C . n 
C 1 49  ASP 49  49  49  ASP ASP C . n 
C 1 50  PRO 50  50  50  PRO PRO C . n 
C 1 51  GLU 51  51  51  GLU GLU C . n 
C 1 52  HIS 52  52  52  HIS HIS C . n 
C 1 53  GLN 53  53  53  GLN GLN C . n 
C 1 54  ASP 54  54  54  ASP ASP C . n 
C 1 55  VAL 55  55  55  VAL VAL C . n 
C 1 56  LEU 56  56  56  LEU LEU C . n 
C 1 57  THR 57  57  57  THR THR C . n 
C 1 58  PHE 58  58  58  PHE PHE C . n 
C 1 59  VAL 59  59  59  VAL VAL C . n 
C 1 60  ASP 60  60  60  ASP ASP C . n 
C 1 61  ASP 61  61  61  ASP ASP C . n 
C 1 62  ASP 62  62  62  ASP ASP C . n 
C 1 63  GLY 63  63  63  GLY GLY C . n 
C 1 64  VAL 64  64  64  VAL VAL C . n 
C 1 65  ARG 65  65  65  ARG ARG C . n 
C 1 66  LYS 66  66  66  LYS LYS C . n 
C 1 67  SER 67  67  67  SER SER C . n 
C 1 68  MET 68  68  68  MET MET C . n 
C 1 69  HIS 69  69  69  HIS HIS C . n 
C 1 70  TRP 70  70  70  TRP TRP C . n 
C 1 71  PHE 71  71  71  PHE PHE C . n 
C 1 72  LEU 72  72  72  LEU LEU C . n 
C 1 73  PRO 73  73  73  PRO PRO C . n 
C 1 74  ARG 74  74  74  ARG ARG C . n 
C 1 75  SER 75  75  75  SER SER C . n 
C 1 76  LYS 76  76  76  LYS LYS C . n 
C 1 77  ALA 77  77  77  ALA ALA C . n 
C 1 78  ASP 78  78  78  ASP ASP C . n 
C 1 79  ALA 79  79  79  ALA ALA C . n 
C 1 80  ALA 80  80  80  ALA ALA C . n 
C 1 81  ARG 81  81  81  ARG ARG C . n 
C 1 82  ARG 82  82  82  ARG ARG C . n 
C 1 83  ARG 83  83  83  ARG ARG C . n 
C 1 84  ALA 84  84  84  ALA ALA C . n 
C 1 85  TYR 85  85  85  TYR TYR C . n 
C 1 86  HIS 86  86  86  HIS HIS C . n 
C 1 87  GLU 87  87  87  GLU GLU C . n 
C 1 88  PHE 88  88  88  PHE PHE C . n 
C 1 89  TRP 89  89  89  TRP TRP C . n 
C 1 90  PHE 90  90  90  PHE PHE C . n 
C 1 91  ARG 91  91  91  ARG ARG C . n 
C 1 92  HIS 92  92  92  HIS HIS C . n 
C 1 93  PHE 93  93  93  PHE PHE C . n 
C 1 94  GLN 94  94  94  GLN GLN C . n 
C 1 95  GLY 95  95  95  GLY GLY C . n 
C 1 96  GLY 96  96  96  GLY GLY C . n 
C 1 97  ILE 97  97  97  ILE ILE C . n 
C 1 98  PHE 98  98  98  PHE PHE C . n 
C 1 99  THR 99  99  99  THR THR C . n 
C 1 100 ARG 100 100 100 ARG ARG C . n 
C 1 101 PRO 101 101 101 PRO PRO C . n 
C 1 102 PRO 102 102 102 PRO PRO C . n 
C 1 103 ALA 103 103 103 ALA ALA C . n 
C 1 104 GLY 104 104 104 GLY GLY C . n 
C 1 105 MET 105 105 105 MET MET C . n 
C 1 106 HIS 106 106 106 HIS HIS C . n 
C 1 107 VAL 107 107 107 VAL VAL C . n 
C 1 108 VAL 108 108 108 VAL VAL C . n 
C 1 109 MET 109 109 109 MET MET C . n 
C 1 110 TYR 110 110 110 TYR TYR C . n 
C 1 111 ALA 111 111 111 ALA ALA C . n 
C 1 112 GLN 112 112 112 GLN GLN C . n 
C 1 113 ILE 113 113 113 ILE ILE C . n 
C 1 114 ASP 114 114 114 ASP ASP C . n 
C 1 115 ASP 115 115 115 ASP ASP C . n 
C 1 116 PRO 116 116 116 PRO PRO C . n 
C 1 117 GLU 117 117 117 GLU GLU C . n 
C 1 118 PRO 118 118 118 PRO PRO C . n 
C 1 119 TRP 119 119 119 TRP TRP C . n 
C 1 120 GLY 120 120 120 GLY GLY C . n 
C 1 121 ASP 121 121 121 ASP ASP C . n 
C 1 122 ASN 122 122 122 ASN ASN C . n 
C 1 123 ALA 123 123 123 ALA ALA C . n 
C 1 124 VAL 124 124 124 VAL VAL C . n 
C 1 125 VAL 125 125 125 VAL VAL C . n 
C 1 126 ALA 126 126 126 ALA ALA C . n 
C 1 127 GLY 127 127 127 GLY GLY C . n 
C 1 128 GLY 128 128 128 GLY GLY C . n 
C 1 129 ARG 129 129 129 ARG ARG C . n 
C 1 130 THR 130 130 130 THR THR C . n 
C 1 131 ILE 131 131 131 ILE ILE C . n 
C 1 132 SER 132 132 132 SER SER C . n 
C 1 133 PHE 133 133 133 PHE PHE C . n 
C 1 134 ALA 134 134 134 ALA ALA C . n 
C 1 135 ASP 135 135 135 ASP ASP C . n 
C 1 136 ASN 136 136 136 ASN ASN C . n 
C 1 137 ILE 137 137 137 ILE ILE C . n 
C 1 138 ARG 138 138 138 ARG ARG C . n 
C 1 139 SER 139 139 139 SER SER C . n 
C 1 140 GLN 140 140 140 GLN GLN C . n 
C 1 141 TRP 141 141 141 TRP TRP C . n 
C 1 142 GLN 142 142 142 GLN GLN C . n 
C 1 143 ARG 143 143 143 ARG ARG C . n 
C 1 144 VAL 144 144 144 VAL VAL C . n 
C 1 145 THR 145 145 145 THR THR C . n 
C 1 146 THR 146 146 146 THR THR C . n 
C 1 147 ASP 147 147 147 ASP ASP C . n 
C 1 148 ASP 148 148 148 ASP ASP C . n 
C 1 149 VAL 149 149 149 VAL VAL C . n 
C 1 150 ALA 150 150 150 ALA ALA C . n 
C 1 151 LEU 151 151 151 LEU LEU C . n 
C 1 152 SER 152 152 152 SER SER C . n 
C 1 153 PRO 153 153 153 PRO PRO C . n 
C 1 154 MET 154 154 154 MET MET C . n 
C 1 155 PHE 155 155 155 PHE PHE C . n 
C 1 156 VAL 156 156 156 VAL VAL C . n 
C 1 157 ASP 157 157 157 ASP ASP C . n 
C 1 158 VAL 158 158 158 VAL VAL C . n 
C 1 159 GLN 159 159 ?   ?   ?   C . n 
C 1 160 PHE 160 160 ?   ?   ?   C . n 
C 1 161 ASP 161 161 ?   ?   ?   C . n 
C 1 162 ARG 162 162 ?   ?   ?   C . n 
C 1 163 GLY 163 163 ?   ?   ?   C . n 
C 1 164 ARG 164 164 ?   ?   ?   C . n 
C 1 165 ASP 165 165 ?   ?   ?   C . n 
C 1 166 ASP 166 166 ?   ?   ?   C . n 
C 1 167 ALA 167 167 ?   ?   ?   C . n 
C 1 168 LEU 168 168 ?   ?   ?   C . n 
C 1 169 VAL 169 169 ?   ?   ?   C . n 
C 1 170 GLU 170 170 170 GLU GLU C . n 
C 1 171 THR 171 171 171 THR THR C . n 
C 1 172 PRO 172 172 172 PRO PRO C . n 
C 1 173 MET 173 173 173 MET MET C . n 
C 1 174 LEU 174 174 174 LEU LEU C . n 
C 1 175 SER 175 175 175 SER SER C . n 
C 1 176 ILE 176 176 176 ILE ILE C . n 
C 1 177 VAL 177 177 177 VAL VAL C . n 
C 1 178 GLU 178 178 178 GLU GLU C . n 
C 1 179 GLN 179 179 179 GLN GLN C . n 
C 1 180 ASN 180 180 180 ASN ASN C . n 
C 1 181 ASP 181 181 181 ASP ASP C . n 
C 1 182 GLN 182 182 182 GLN GLN C . n 
C 1 183 GLY 183 183 183 GLY GLY C . n 
C 1 184 ILE 184 184 184 ILE ILE C . n 
C 1 185 VAL 185 185 185 VAL VAL C . n 
C 1 186 VAL 186 186 186 VAL VAL C . n 
C 1 187 ARG 187 187 187 ARG ARG C . n 
C 1 188 GLY 188 188 188 GLY GLY C . n 
C 1 189 TRP 189 189 189 TRP TRP C . n 
C 1 190 LYS 190 190 190 LYS LYS C . n 
C 1 191 ALA 191 191 191 ALA ALA C . n 
C 1 192 MET 192 192 192 MET MET C . n 
C 1 193 GLY 193 193 193 GLY GLY C . n 
C 1 194 THR 194 194 194 THR THR C . n 
C 1 195 SER 195 195 195 SER SER C . n 
C 1 196 LEU 196 196 196 LEU LEU C . n 
C 1 197 PRO 197 197 197 PRO PRO C . n 
C 1 198 PHE 198 198 198 PHE PHE C . n 
C 1 199 VAL 199 199 199 VAL VAL C . n 
C 1 200 ASN 200 200 200 ASN ASN C . n 
C 1 201 GLU 201 201 201 GLU GLU C . n 
C 1 202 LEU 202 202 202 LEU LEU C . n 
C 1 203 LEU 203 203 203 LEU LEU C . n 
C 1 204 VAL 204 204 204 VAL VAL C . n 
C 1 205 GLY 205 205 205 GLY GLY C . n 
C 1 206 ASN 206 206 206 ASN ASN C . n 
C 1 207 LEU 207 207 207 LEU LEU C . n 
C 1 208 TRP 208 208 208 TRP TRP C . n 
C 1 209 ARG 209 209 209 ARG ARG C . n 
C 1 210 PRO 210 210 210 PRO PRO C . n 
C 1 211 GLY 211 211 211 GLY GLY C . n 
C 1 212 GLN 212 212 212 GLN GLN C . n 
C 1 213 THR 213 213 213 THR THR C . n 
C 1 214 SER 214 214 214 SER SER C . n 
C 1 215 ASP 215 215 215 ASP ASP C . n 
C 1 216 GLN 216 216 216 GLN GLN C . n 
C 1 217 THR 217 217 217 THR THR C . n 
C 1 218 VAL 218 218 218 VAL VAL C . n 
C 1 219 TYR 219 219 219 TYR TYR C . n 
C 1 220 ALA 220 220 220 ALA ALA C . n 
C 1 221 ILE 221 221 221 ILE ILE C . n 
C 1 222 VAL 222 222 222 VAL VAL C . n 
C 1 223 PRO 223 223 223 PRO PRO C . n 
C 1 224 VAL 224 224 224 VAL VAL C . n 
C 1 225 ASN 225 225 225 ASN ASN C . n 
C 1 226 THR 226 226 226 THR THR C . n 
C 1 227 PRO 227 227 227 PRO PRO C . n 
C 1 228 GLY 228 228 228 GLY GLY C . n 
C 1 229 LEU 229 229 229 LEU LEU C . n 
C 1 230 SER 230 230 230 SER SER C . n 
C 1 231 LEU 231 231 231 LEU LEU C . n 
C 1 232 VAL 232 232 232 VAL VAL C . n 
C 1 233 CYS 233 233 233 CYS CYS C . n 
C 1 234 ARG 234 234 234 ARG ARG C . n 
C 1 235 GLN 235 235 235 GLN GLN C . n 
C 1 236 SER 236 236 236 SER SER C . n 
C 1 237 ASN 237 237 237 ASN ASN C . n 
C 1 238 ALA 238 238 238 ALA ALA C . n 
C 1 239 THR 239 239 239 THR THR C . n 
C 1 240 PRO 240 240 240 PRO PRO C . n 
C 1 241 ASP 241 241 241 ASP ASP C . n 
C 1 242 ALA 242 242 242 ALA ALA C . n 
C 1 243 ASP 243 243 243 ASP ASP C . n 
C 1 244 PRO 244 244 244 PRO PRO C . n 
C 1 245 TYR 245 245 245 TYR TYR C . n 
C 1 246 ASP 246 246 246 ASP ASP C . n 
C 1 247 HIS 247 247 247 HIS HIS C . n 
C 1 248 PRO 248 248 248 PRO PRO C . n 
C 1 249 LEU 249 249 249 LEU LEU C . n 
C 1 250 SER 250 250 250 SER SER C . n 
C 1 251 THR 251 251 251 THR THR C . n 
C 1 252 ILE 252 252 252 ILE ILE C . n 
C 1 253 GLY 253 253 253 GLY GLY C . n 
C 1 254 ASP 254 254 254 ASP ASP C . n 
C 1 255 GLU 255 255 255 GLU GLU C . n 
C 1 256 LEU 256 256 256 LEU LEU C . n 
C 1 257 ASP 257 257 257 ASP ASP C . n 
C 1 258 GLY 258 258 258 GLY GLY C . n 
C 1 259 MET 259 259 259 MET MET C . n 
C 1 260 ALA 260 260 260 ALA ALA C . n 
C 1 261 TYR 261 261 261 TYR TYR C . n 
C 1 262 PHE 262 262 262 PHE PHE C . n 
C 1 263 ASP 263 263 263 ASP ASP C . n 
C 1 264 ASP 264 264 264 ASP ASP C . n 
C 1 265 VAL 265 265 265 VAL VAL C . n 
C 1 266 PHE 266 266 266 PHE PHE C . n 
C 1 267 ILE 267 267 267 ILE ILE C . n 
C 1 268 PRO 268 268 268 PRO PRO C . n 
C 1 269 TRP 269 269 269 TRP TRP C . n 
C 1 270 GLU 270 270 270 GLU GLU C . n 
C 1 271 ASN 271 271 271 ASN ASN C . n 
C 1 272 VAL 272 272 272 VAL VAL C . n 
C 1 273 GLN 273 273 273 GLN GLN C . n 
C 1 274 HIS 274 274 274 HIS HIS C . n 
C 1 275 ILE 275 275 275 ILE ILE C . n 
C 1 276 GLY 276 276 276 GLY GLY C . n 
C 1 277 ASN 277 277 277 ASN ASN C . n 
C 1 278 PRO 278 278 278 PRO PRO C . n 
C 1 279 ASP 279 279 279 ASP ASP C . n 
C 1 280 HIS 280 280 280 HIS HIS C . n 
C 1 281 ALA 281 281 281 ALA ALA C . n 
C 1 282 LYS 282 282 282 LYS LYS C . n 
C 1 283 TRP 283 283 283 TRP TRP C . n 
C 1 284 TYR 284 284 284 TYR TYR C . n 
C 1 285 PRO 285 285 285 PRO PRO C . n 
C 1 286 GLN 286 286 286 GLN GLN C . n 
C 1 287 ARG 287 287 287 ARG ARG C . n 
C 1 288 GLN 288 288 288 GLN GLN C . n 
C 1 289 PHE 289 289 289 PHE PHE C . n 
C 1 290 ASP 290 290 290 ASP ASP C . n 
C 1 291 TRP 291 291 291 TRP TRP C . n 
C 1 292 VAL 292 292 292 VAL VAL C . n 
C 1 293 HIS 293 293 293 HIS HIS C . n 
C 1 294 ILE 294 294 294 ILE ILE C . n 
C 1 295 GLU 295 295 295 GLU GLU C . n 
C 1 296 THR 296 296 296 THR THR C . n 
C 1 297 GLN 297 297 297 GLN GLN C . n 
C 1 298 ILE 298 298 298 ILE ILE C . n 
C 1 299 ARG 299 299 299 ARG ARG C . n 
C 1 300 HIS 300 300 300 HIS HIS C . n 
C 1 301 ALA 301 301 301 ALA ALA C . n 
C 1 302 VAL 302 302 302 VAL VAL C . n 
C 1 303 HIS 303 303 303 HIS HIS C . n 
C 1 304 ALA 304 304 304 ALA ALA C . n 
C 1 305 GLU 305 305 305 GLU GLU C . n 
C 1 306 LEU 306 306 306 LEU LEU C . n 
C 1 307 ILE 307 307 307 ILE ILE C . n 
C 1 308 VAL 308 308 308 VAL VAL C . n 
C 1 309 GLY 309 309 309 GLY GLY C . n 
C 1 310 LEU 310 310 310 LEU LEU C . n 
C 1 311 ALA 311 311 311 ALA ALA C . n 
C 1 312 LEU 312 312 312 LEU LEU C . n 
C 1 313 LEU 313 313 313 LEU LEU C . n 
C 1 314 LEU 314 314 314 LEU LEU C . n 
C 1 315 THR 315 315 315 THR THR C . n 
C 1 316 ASN 316 316 316 ASN ASN C . n 
C 1 317 ALA 317 317 317 ALA ALA C . n 
C 1 318 LEU 318 318 318 LEU LEU C . n 
C 1 319 GLY 319 319 319 GLY GLY C . n 
C 1 320 THR 320 320 320 THR THR C . n 
C 1 321 ASN 321 321 321 ASN ASN C . n 
C 1 322 ASN 322 322 322 ASN ASN C . n 
C 1 323 ASN 323 323 323 ASN ASN C . n 
C 1 324 PRO 324 324 324 PRO PRO C . n 
C 1 325 ILE 325 325 325 ILE ILE C . n 
C 1 326 VAL 326 326 326 VAL VAL C . n 
C 1 327 GLN 327 327 327 GLN GLN C . n 
C 1 328 SER 328 328 328 SER SER C . n 
C 1 329 GLN 329 329 329 GLN GLN C . n 
C 1 330 LEU 330 330 330 LEU LEU C . n 
C 1 331 ALA 331 331 331 ALA ALA C . n 
C 1 332 ASP 332 332 332 ASP ASP C . n 
C 1 333 LEU 333 333 333 LEU LEU C . n 
C 1 334 VAL 334 334 334 VAL VAL C . n 
C 1 335 ARG 335 335 335 ARG ARG C . n 
C 1 336 PHE 336 336 336 PHE PHE C . n 
C 1 337 ARG 337 337 337 ARG ARG C . n 
C 1 338 GLU 338 338 338 GLU GLU C . n 
C 1 339 THR 339 339 339 THR THR C . n 
C 1 340 CYS 340 340 340 CYS CYS C . n 
C 1 341 LYS 341 341 341 LYS LYS C . n 
C 1 342 ALA 342 342 342 ALA ALA C . n 
C 1 343 PHE 343 343 343 PHE PHE C . n 
C 1 344 ALA 344 344 344 ALA ALA C . n 
C 1 345 ILE 345 345 345 ILE ILE C . n 
C 1 346 ALA 346 346 346 ALA ALA C . n 
C 1 347 ALA 347 347 347 ALA ALA C . n 
C 1 348 GLU 348 348 348 GLU GLU C . n 
C 1 349 GLU 349 349 349 GLU GLU C . n 
C 1 350 THR 350 350 350 THR THR C . n 
C 1 351 GLY 351 351 351 GLY GLY C . n 
C 1 352 PHE 352 352 352 PHE PHE C . n 
C 1 353 THR 353 353 353 THR THR C . n 
C 1 354 THR 354 354 354 THR THR C . n 
C 1 355 ALA 355 355 355 ALA ALA C . n 
C 1 356 GLY 356 356 356 GLY GLY C . n 
C 1 357 GLY 357 357 357 GLY GLY C . n 
C 1 358 LEU 358 358 358 LEU LEU C . n 
C 1 359 PHE 359 359 359 PHE PHE C . n 
C 1 360 LYS 360 360 360 LYS LYS C . n 
C 1 361 PRO 361 361 361 PRO PRO C . n 
C 1 362 ASN 362 362 362 ASN ASN C . n 
C 1 363 ASN 363 363 363 ASN ASN C . n 
C 1 364 ILE 364 364 364 ILE ILE C . n 
C 1 365 TYR 365 365 365 TYR TYR C . n 
C 1 366 VAL 366 366 366 VAL VAL C . n 
C 1 367 ASP 367 367 367 ASP ASP C . n 
C 1 368 LEU 368 368 368 LEU LEU C . n 
C 1 369 GLY 369 369 369 GLY GLY C . n 
C 1 370 ARG 370 370 370 ARG ARG C . n 
C 1 371 ALA 371 371 371 ALA ALA C . n 
C 1 372 HIS 372 372 372 HIS HIS C . n 
C 1 373 TYR 373 373 373 TYR TYR C . n 
C 1 374 LEU 374 374 374 LEU LEU C . n 
C 1 375 GLU 375 375 375 GLU GLU C . n 
C 1 376 ASN 376 376 376 ASN ASN C . n 
C 1 377 ILE 377 377 377 ILE ILE C . n 
C 1 378 HIS 378 378 378 HIS HIS C . n 
C 1 379 ASN 379 379 379 ASN ASN C . n 
C 1 380 ALA 380 380 380 ALA ALA C . n 
C 1 381 VAL 381 381 381 VAL VAL C . n 
C 1 382 ASN 382 382 382 ASN ASN C . n 
C 1 383 GLN 383 383 383 GLN GLN C . n 
C 1 384 LEU 384 384 384 LEU LEU C . n 
C 1 385 ILE 385 385 385 ILE ILE C . n 
C 1 386 GLU 386 386 386 GLU GLU C . n 
C 1 387 PHE 387 387 387 PHE PHE C . n 
C 1 388 CYS 388 388 388 CYS CYS C . n 
C 1 389 GLY 389 389 389 GLY GLY C . n 
C 1 390 ARG 390 390 390 ARG ARG C . n 
C 1 391 GLY 391 391 391 GLY GLY C . n 
C 1 392 VAL 392 392 392 VAL VAL C . n 
C 1 393 VAL 393 393 393 VAL VAL C . n 
C 1 394 MET 394 394 394 MET MET C . n 
C 1 395 SER 395 395 395 SER SER C . n 
C 1 396 PRO 396 396 396 PRO PRO C . n 
C 1 397 THR 397 397 397 THR THR C . n 
C 1 398 LYS 398 398 398 LYS LYS C . n 
C 1 399 ALA 399 399 399 ALA ALA C . n 
C 1 400 ASP 400 400 400 ASP ASP C . n 
C 1 401 PHE 401 401 401 PHE PHE C . n 
C 1 402 ASP 402 402 402 ASP ASP C . n 
C 1 403 HIS 403 403 403 HIS HIS C . n 
C 1 404 PRO 404 404 404 PRO PRO C . n 
C 1 405 PHE 405 405 405 PHE PHE C . n 
C 1 406 LEU 406 406 406 LEU LEU C . n 
C 1 407 GLY 407 407 407 GLY GLY C . n 
C 1 408 PRO 408 408 408 PRO PRO C . n 
C 1 409 LYS 409 409 409 LYS LYS C . n 
C 1 410 LEU 410 410 410 LEU LEU C . n 
C 1 411 GLU 411 411 411 GLU GLU C . n 
C 1 412 GLU 412 412 412 GLU GLU C . n 
C 1 413 ALA 413 413 413 ALA ALA C . n 
C 1 414 LEU 414 414 414 LEU LEU C . n 
C 1 415 ARG 415 415 415 ARG ARG C . n 
C 1 416 GLY 416 416 416 GLY GLY C . n 
C 1 417 THR 417 417 417 THR THR C . n 
C 1 418 SER 418 418 418 SER SER C . n 
C 1 419 ILE 419 419 419 ILE ILE C . n 
C 1 420 SER 420 420 420 SER SER C . n 
C 1 421 ALA 421 421 421 ALA ALA C . n 
C 1 422 ARG 422 422 422 ARG ARG C . n 
C 1 423 ASP 423 423 423 ASP ASP C . n 
C 1 424 ARG 424 424 424 ARG ARG C . n 
C 1 425 VAL 425 425 425 VAL VAL C . n 
C 1 426 SER 426 426 426 SER SER C . n 
C 1 427 ILE 427 427 427 ILE ILE C . n 
C 1 428 PHE 428 428 428 PHE PHE C . n 
C 1 429 ARG 429 429 429 ARG ARG C . n 
C 1 430 GLN 430 430 430 GLN GLN C . n 
C 1 431 ILE 431 431 431 ILE ILE C . n 
C 1 432 SER 432 432 432 SER SER C . n 
C 1 433 GLU 433 433 433 GLU GLU C . n 
C 1 434 ARG 434 434 434 ARG ARG C . n 
C 1 435 TYR 435 435 435 TYR TYR C . n 
C 1 436 LEU 436 436 436 LEU LEU C . n 
C 1 437 THR 437 437 437 THR THR C . n 
C 1 438 GLN 438 438 438 GLN GLN C . n 
C 1 439 TRP 439 439 439 TRP TRP C . n 
C 1 440 GLY 440 440 440 GLY GLY C . n 
C 1 441 ALA 441 441 441 ALA ALA C . n 
C 1 442 ARG 442 442 442 ARG ARG C . n 
C 1 443 HIS 443 443 443 HIS HIS C . n 
C 1 444 GLU 444 444 444 GLU GLU C . n 
C 1 445 MET 445 445 445 MET MET C . n 
C 1 446 PHE 446 446 446 PHE PHE C . n 
C 1 447 GLU 447 447 447 GLU GLU C . n 
C 1 448 LYS 448 448 448 LYS LYS C . n 
C 1 449 PHE 449 449 449 PHE PHE C . n 
C 1 450 ASN 450 450 450 ASN ASN C . n 
C 1 451 GLY 451 451 451 GLY GLY C . n 
C 1 452 THR 452 452 452 THR THR C . n 
C 1 453 PRO 453 453 453 PRO PRO C . n 
C 1 454 LEU 454 454 454 LEU LEU C . n 
C 1 455 TYR 455 455 455 TYR TYR C . n 
C 1 456 LEU 456 456 456 LEU LEU C . n 
C 1 457 VAL 457 457 457 VAL VAL C . n 
C 1 458 ARG 458 458 458 ARG ARG C . n 
C 1 459 LEU 459 459 459 LEU LEU C . n 
C 1 460 LEU 460 460 460 LEU LEU C . n 
C 1 461 THR 461 461 461 THR THR C . n 
C 1 462 MET 462 462 462 MET MET C . n 
C 1 463 GLN 463 463 463 GLN GLN C . n 
C 1 464 ARG 464 464 464 ARG ARG C . n 
C 1 465 THR 465 465 465 THR THR C . n 
C 1 466 GLU 466 466 466 GLU GLU C . n 
C 1 467 TYR 467 467 467 TYR TYR C . n 
C 1 468 GLN 468 468 468 GLN GLN C . n 
C 1 469 VAL 469 469 469 VAL VAL C . n 
C 1 470 ASP 470 470 470 ASP ASP C . n 
C 1 471 GLY 471 471 471 GLY GLY C . n 
C 1 472 PRO 472 472 472 PRO PRO C . n 
C 1 473 LEU 473 473 473 LEU LEU C . n 
C 1 474 THR 474 474 474 THR THR C . n 
C 1 475 ASP 475 475 475 ASP ASP C . n 
C 1 476 LEU 476 476 476 LEU LEU C . n 
C 1 477 ALA 477 477 477 ALA ALA C . n 
C 1 478 ARG 478 478 478 ARG ARG C . n 
C 1 479 GLN 479 479 479 GLN GLN C . n 
C 1 480 VAL 480 480 480 VAL VAL C . n 
C 1 481 LEU 481 481 481 LEU LEU C . n 
C 1 482 GLY 482 482 482 GLY GLY C . n 
C 1 483 PHE 483 483 483 PHE PHE C . n 
C 1 484 GLY 484 484 484 GLY GLY C . n 
C 1 485 ASP 485 485 485 ASP ASP C . n 
C 1 486 THR 486 486 486 THR THR C . n 
C 1 487 GLU 487 487 487 GLU GLU C . n 
C 1 488 ALA 488 488 488 ALA ALA C . n 
C 1 489 LEU 489 489 489 LEU LEU C . n 
C 1 490 ALA 490 490 490 ALA ALA C . n 
C 1 491 ALA 491 491 491 ALA ALA C . n 
C 1 492 ARG 492 492 492 ARG ARG C . n 
C 1 493 ALA 493 493 493 ALA ALA C . n 
C 1 494 ALA 494 494 494 ALA ALA C . n 
C 1 495 GLU 495 495 495 GLU GLU C . n 
C 1 496 VAL 496 496 496 VAL VAL C . n 
C 1 497 GLU 497 497 497 GLU GLU C . n 
C 1 498 LYS 498 498 498 LYS LYS C . n 
C 1 499 ASN 499 499 ?   ?   ?   C . n 
C 1 500 SER 500 500 ?   ?   ?   C . n 
C 1 501 ASN 501 501 ?   ?   ?   C . n 
C 1 502 TRP 502 502 ?   ?   ?   C . n 
C 1 503 ALA 503 503 ?   ?   ?   C . n 
C 1 504 SER 504 504 ?   ?   ?   C . n 
C 1 505 VAL 505 505 ?   ?   ?   C . n 
C 1 506 ALA 506 506 ?   ?   ?   C . n 
C 1 507 TYR 507 507 ?   ?   ?   C . n 
C 1 508 GLN 508 508 ?   ?   ?   C . n 
C 1 509 PRO 509 509 ?   ?   ?   C . n 
C 1 510 GLU 510 510 ?   ?   ?   C . n 
C 1 511 TYR 511 511 ?   ?   ?   C . n 
C 1 512 ALA 512 512 ?   ?   ?   C . n 
C 1 513 ARG 513 513 ?   ?   ?   C . n 
C 1 514 GLU 514 514 ?   ?   ?   C . n 
C 1 515 GLN 515 515 ?   ?   ?   C . n 
C 1 516 ASP 516 516 ?   ?   ?   C . n 
C 1 517 VAL 517 517 ?   ?   ?   C . n 
C 1 518 ARG 518 518 ?   ?   ?   C . n 
C 1 519 ASP 519 519 ?   ?   ?   C . n 
C 1 520 GLY 520 520 ?   ?   ?   C . n 
C 1 521 TYR 521 521 ?   ?   ?   C . n 
C 1 522 TYR 522 522 ?   ?   ?   C . n 
C 1 523 LYS 523 523 ?   ?   ?   C . n 
C 1 524 GLU 524 524 ?   ?   ?   C . n 
C 1 525 THR 525 525 ?   ?   ?   C . n 
C 1 526 GLU 526 526 ?   ?   ?   C . n 
C 1 527 LYS 527 527 ?   ?   ?   C . n 
C 1 528 VAL 528 528 ?   ?   ?   C . n 
C 1 529 LEU 529 529 ?   ?   ?   C . n 
C 1 530 GLU 530 530 ?   ?   ?   C . n 
C 1 531 HIS 531 531 ?   ?   ?   C . n 
C 1 532 HIS 532 532 ?   ?   ?   C . n 
C 1 533 HIS 533 533 ?   ?   ?   C . n 
C 1 534 HIS 534 534 ?   ?   ?   C . n 
C 1 535 HIS 535 535 ?   ?   ?   C . n 
C 1 536 HIS 536 536 ?   ?   ?   C . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
D 2 HOH 1  601 707  HOH HOH A . 
D 2 HOH 2  602 32   HOH HOH A . 
D 2 HOH 3  603 31   HOH HOH A . 
D 2 HOH 4  604 23   HOH HOH A . 
D 2 HOH 5  605 429  HOH HOH A . 
D 2 HOH 6  606 13   HOH HOH A . 
D 2 HOH 7  607 38   HOH HOH A . 
D 2 HOH 8  608 98   HOH HOH A . 
D 2 HOH 9  609 15   HOH HOH A . 
D 2 HOH 10 610 69   HOH HOH A . 
D 2 HOH 11 611 212  HOH HOH A . 
D 2 HOH 12 612 8    HOH HOH A . 
D 2 HOH 13 613 43   HOH HOH A . 
D 2 HOH 14 614 16   HOH HOH A . 
D 2 HOH 15 615 76   HOH HOH A . 
D 2 HOH 16 616 160  HOH HOH A . 
D 2 HOH 17 617 577  HOH HOH A . 
D 2 HOH 18 618 238  HOH HOH A . 
D 2 HOH 19 619 86   HOH HOH A . 
D 2 HOH 20 620 19   HOH HOH A . 
D 2 HOH 21 621 1    HOH HOH A . 
D 2 HOH 22 622 682  HOH HOH A . 
D 2 HOH 23 623 749  HOH HOH A . 
D 2 HOH 24 624 6    HOH HOH A . 
D 2 HOH 25 625 44   HOH HOH A . 
D 2 HOH 26 626 252  HOH HOH A . 
D 2 HOH 27 627 259  HOH HOH A . 
D 2 HOH 28 628 1116 HOH HOH A . 
D 2 HOH 29 629 5    HOH HOH A . 
D 2 HOH 30 630 42   HOH HOH A . 
D 2 HOH 31 631 294  HOH HOH A . 
D 2 HOH 32 632 30   HOH HOH A . 
D 2 HOH 33 633 10   HOH HOH A . 
D 2 HOH 34 634 751  HOH HOH A . 
D 2 HOH 35 635 46   HOH HOH A . 
D 2 HOH 36 636 143  HOH HOH A . 
D 2 HOH 37 637 99   HOH HOH A . 
D 2 HOH 38 638 11   HOH HOH A . 
D 2 HOH 39 639 22   HOH HOH A . 
D 2 HOH 40 640 26   HOH HOH A . 
D 2 HOH 41 641 194  HOH HOH A . 
D 2 HOH 42 642 7    HOH HOH A . 
D 2 HOH 43 643 50   HOH HOH A . 
D 2 HOH 44 644 115  HOH HOH A . 
D 2 HOH 45 645 109  HOH HOH A . 
D 2 HOH 46 646 74   HOH HOH A . 
D 2 HOH 47 647 73   HOH HOH A . 
D 2 HOH 48 648 221  HOH HOH A . 
D 2 HOH 49 649 241  HOH HOH A . 
D 2 HOH 50 650 95   HOH HOH A . 
D 2 HOH 51 651 36   HOH HOH A . 
D 2 HOH 52 652 552  HOH HOH A . 
D 2 HOH 53 653 39   HOH HOH A . 
D 2 HOH 54 654 905  HOH HOH A . 
D 2 HOH 55 655 715  HOH HOH A . 
D 2 HOH 56 656 14   HOH HOH A . 
D 2 HOH 57 657 107  HOH HOH A . 
D 2 HOH 58 658 49   HOH HOH A . 
D 2 HOH 59 659 51   HOH HOH A . 
D 2 HOH 60 660 41   HOH HOH A . 
D 2 HOH 61 661 719  HOH HOH A . 
D 2 HOH 62 662 566  HOH HOH A . 
D 2 HOH 63 663 114  HOH HOH A . 
D 2 HOH 64 664 72   HOH HOH A . 
D 2 HOH 65 665 706  HOH HOH A . 
D 2 HOH 66 666 621  HOH HOH A . 
D 2 HOH 67 667 652  HOH HOH A . 
D 2 HOH 68 668 233  HOH HOH A . 
D 2 HOH 69 669 922  HOH HOH A . 
D 2 HOH 70 670 292  HOH HOH A . 
D 2 HOH 71 671 93   HOH HOH A . 
D 2 HOH 72 672 307  HOH HOH A . 
D 2 HOH 73 673 89   HOH HOH A . 
D 2 HOH 74 674 490  HOH HOH A . 
E 2 HOH 1  601 789  HOH HOH B . 
E 2 HOH 2  602 161  HOH HOH B . 
E 2 HOH 3  603 123  HOH HOH B . 
E 2 HOH 4  604 68   HOH HOH B . 
E 2 HOH 5  605 45   HOH HOH B . 
E 2 HOH 6  606 686  HOH HOH B . 
E 2 HOH 7  607 134  HOH HOH B . 
E 2 HOH 8  608 3    HOH HOH B . 
E 2 HOH 9  609 77   HOH HOH B . 
E 2 HOH 10 610 897  HOH HOH B . 
E 2 HOH 11 611 2    HOH HOH B . 
E 2 HOH 12 612 208  HOH HOH B . 
E 2 HOH 13 613 66   HOH HOH B . 
E 2 HOH 14 614 646  HOH HOH B . 
E 2 HOH 15 615 647  HOH HOH B . 
E 2 HOH 16 616 106  HOH HOH B . 
E 2 HOH 17 617 422  HOH HOH B . 
E 2 HOH 18 618 84   HOH HOH B . 
E 2 HOH 19 619 29   HOH HOH B . 
E 2 HOH 20 620 779  HOH HOH B . 
E 2 HOH 21 621 112  HOH HOH B . 
E 2 HOH 22 622 138  HOH HOH B . 
E 2 HOH 23 623 140  HOH HOH B . 
E 2 HOH 24 624 101  HOH HOH B . 
E 2 HOH 25 625 91   HOH HOH B . 
E 2 HOH 26 626 678  HOH HOH B . 
E 2 HOH 27 627 82   HOH HOH B . 
E 2 HOH 28 628 356  HOH HOH B . 
E 2 HOH 29 629 186  HOH HOH B . 
E 2 HOH 30 630 962  HOH HOH B . 
E 2 HOH 31 631 459  HOH HOH B . 
F 2 HOH 1  601 75   HOH HOH C . 
F 2 HOH 2  602 193  HOH HOH C . 
F 2 HOH 3  603 97   HOH HOH C . 
F 2 HOH 4  604 118  HOH HOH C . 
F 2 HOH 5  605 28   HOH HOH C . 
F 2 HOH 6  606 281  HOH HOH C . 
F 2 HOH 7  607 64   HOH HOH C . 
F 2 HOH 8  608 524  HOH HOH C . 
F 2 HOH 9  609 104  HOH HOH C . 
F 2 HOH 10 610 148  HOH HOH C . 
F 2 HOH 11 611 81   HOH HOH C . 
F 2 HOH 12 612 145  HOH HOH C . 
F 2 HOH 13 613 657  HOH HOH C . 
F 2 HOH 14 614 116  HOH HOH C . 
F 2 HOH 15 615 119  HOH HOH C . 
F 2 HOH 16 616 20   HOH HOH C . 
F 2 HOH 17 617 809  HOH HOH C . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC  ? ? ? 5.8.0425 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .        2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .        3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? MOLREP  ? ? ? .        4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9J9J 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     149.561 
_cell.length_a_esd                 ? 
_cell.length_b                     149.561 
_cell.length_b_esd                 ? 
_cell.length_c                     322.141 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        48 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9J9J 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                98 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'I 41 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9J9J 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.47 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          50.12 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.056 M NaH2PO4, 1.344 M K2HPO4' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS3 S 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2018-11-18 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.000000 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'PHOTON FACTORY BEAMLINE BL-17A' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.000000 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL-17A 
_diffrn_source.pdbx_synchrotron_site       'Photon Factory' 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9J9J 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.40 
_reflns.d_resolution_low                               49.32 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     71504 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.8 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                13.4 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          21.2 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               1.02 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.080 
_reflns.pdbx_Rpim_I_all                                0.022 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   1.000 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.077 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.40 
_reflns_shell.d_res_low                                     2.45 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           62127 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             4527 
_reflns_shell.percent_possible_obs                          99.1 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               13.7 
_reflns_shell.pdbx_chi_squared                              1.00 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     2.6 
_reflns_shell.pdbx_Rrim_I_all                               1.185 
_reflns_shell.pdbx_Rpim_I_all                               0.317 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.923 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.141 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            0.79 
_refine.aniso_B[1][2]                            -0.00 
_refine.aniso_B[1][3]                            -0.00 
_refine.aniso_B[2][2]                            0.79 
_refine.aniso_B[2][3]                            -0.00 
_refine.aniso_B[3][3]                            -1.58 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               56.615 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.965 
_refine.correlation_coeff_Fo_to_Fc_free          0.944 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9J9J 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.40 
_refine.ls_d_res_low                             49.27 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     67885 
_refine.ls_number_reflns_R_free                  3620 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.84 
_refine.ls_percent_reflns_R_free                 5.1 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.23006 
_refine.ls_R_factor_R_free                       0.28188 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.22727 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          SAD 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.421 
_refine.pdbx_overall_ESU_R_Free                  0.287 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             9.218 
_refine.overall_SU_ML                            0.209 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.40 
_refine_hist.d_res_low                        49.27 
_refine_hist.number_atoms_solvent             122 
_refine_hist.number_atoms_total               11841 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        11719 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.007  0.012  12023 ? r_bond_refined_d             ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.016  11038 ? r_bond_other_d               ? ? 
'X-RAY DIFFRACTION' ? 1.551  1.814  16369 ? r_angle_refined_deg          ? ? 
'X-RAY DIFFRACTION' ? 0.560  1.761  25297 ? r_angle_other_deg            ? ? 
'X-RAY DIFFRACTION' ? 6.670  5.000  1465  ? r_dihedral_angle_1_deg       ? ? 
'X-RAY DIFFRACTION' ? 8.280  5.000  96    ? r_dihedral_angle_2_deg       ? ? 
'X-RAY DIFFRACTION' ? 13.993 10.000 1878  ? r_dihedral_angle_3_deg       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_dihedral_angle_4_deg       ? ? 
'X-RAY DIFFRACTION' ? 0.078  0.200  1765  ? r_chiral_restr               ? ? 
'X-RAY DIFFRACTION' ? 0.006  0.020  14654 ? r_gen_planes_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.020  2976  ? r_gen_planes_other           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbd_refined                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbd_other                  ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbtor_refined              ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbtor_other                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_xyhbond_nbd_refined        ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_xyhbond_nbd_other          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_metal_ion_refined          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_metal_ion_other            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_vdw_refined       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_vdw_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_hbond_refined     ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_hbond_other       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_metal_ion_refined ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_metal_ion_other   ? ? 
'X-RAY DIFFRACTION' ? 4.484  5.536  5878  ? r_mcbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 4.477  5.537  5878  ? r_mcbond_other               ? ? 
'X-RAY DIFFRACTION' ? 6.219  9.946  7337  ? r_mcangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 6.220  9.946  7338  ? r_mcangle_other              ? ? 
'X-RAY DIFFRACTION' ? 4.931  5.957  6145  ? r_scbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 4.931  5.957  6146  ? r_scbond_other               ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_scangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 7.195  10.768 9033  ? r_scangle_other              ? ? 
'X-RAY DIFFRACTION' ? 9.006  52.34  13499 ? r_long_range_B_refined       ? ? 
'X-RAY DIFFRACTION' ? 9.012  52.36  13477 ? r_long_range_B_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_rigid_bond_restr           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_sphericity_free            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_sphericity_bonded          ? ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       2.40 
_refine_ls_shell.d_res_low                        2.460 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             248 
_refine_ls_shell.number_reflns_R_work             4934 
_refine_ls_shell.percent_reflns_obs               99.04 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  0.317 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   ? 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.356 
# 
_struct.entry_id                     9J9J 
_struct.title                        'Nitrophenol monooxygenase RsPNPA from Rhodococcus sp. 21391' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9J9J 
_struct_keywords.text            Oxidoreductase 
_struct_keywords.pdbx_keywords   OXIDOREDUCTASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 1 ? 
D N N 2 ? 
E N N 2 ? 
F N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    NPCA_RHOOP 
_struct_ref.pdbx_db_accession          Q6F4M8 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MRTGQQYLESLRDGRQVYVGGELIDDVTTHPKTSGYAKAIAEYYDLHLDPEHQDVLTFVDDDGVRKSMHWFLPRSKADAA
RRRAYHEFWFRHFQGGIFTRPPAGMHVVMYAQIDDPEPWGDNAVVAGGRTISFADNIRSQWQRVTTDDVALSPMFVDVQF
DRGRDDALVETPMLSIVEQNDQGIVVRGWKAMGTSLPFVNELLVGNLWRPGQTSDQTVYAIVPVNTPGLSLVCRQSNATP
DADPYDHPLSTIGDELDGMAYFDDVFIPWENVQHIGNPDHAKWYPQRQFDWVHIETQIRHAVHAELIVGLALLLTNALGT
NNNPIVQSQLADLVRFRETCKAFAIAAEETGFTTAGGLFKPNNIYVDLGRAHYLENIHNAVNQLIEFCGRGVVMSPTKAD
FDHPFLGPKLEEALRGTSISARDRVSIFRQISERYLTQWGARHEMFEKFNGTPLYLVRLLTMQRTEYQVDGPLTDLARQV
LGFGDTEALAARAAEVEKNSNWASVAYQPEYAREQDVRDGYYKETEKV
;
_struct_ref.pdbx_align_begin           1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9J9J A 1 ? 528 ? Q6F4M8 1 ? 528 ? 1 528 
2 1 9J9J B 1 ? 528 ? Q6F4M8 1 ? 528 ? 1 528 
3 1 9J9J C 1 ? 528 ? Q6F4M8 1 ? 528 ? 1 528 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9J9J LEU A 529 ? UNP Q6F4M8 ? ? 'expression tag' 529 1  
1 9J9J GLU A 530 ? UNP Q6F4M8 ? ? 'expression tag' 530 2  
1 9J9J HIS A 531 ? UNP Q6F4M8 ? ? 'expression tag' 531 3  
1 9J9J HIS A 532 ? UNP Q6F4M8 ? ? 'expression tag' 532 4  
1 9J9J HIS A 533 ? UNP Q6F4M8 ? ? 'expression tag' 533 5  
1 9J9J HIS A 534 ? UNP Q6F4M8 ? ? 'expression tag' 534 6  
1 9J9J HIS A 535 ? UNP Q6F4M8 ? ? 'expression tag' 535 7  
1 9J9J HIS A 536 ? UNP Q6F4M8 ? ? 'expression tag' 536 8  
2 9J9J LEU B 529 ? UNP Q6F4M8 ? ? 'expression tag' 529 9  
2 9J9J GLU B 530 ? UNP Q6F4M8 ? ? 'expression tag' 530 10 
2 9J9J HIS B 531 ? UNP Q6F4M8 ? ? 'expression tag' 531 11 
2 9J9J HIS B 532 ? UNP Q6F4M8 ? ? 'expression tag' 532 12 
2 9J9J HIS B 533 ? UNP Q6F4M8 ? ? 'expression tag' 533 13 
2 9J9J HIS B 534 ? UNP Q6F4M8 ? ? 'expression tag' 534 14 
2 9J9J HIS B 535 ? UNP Q6F4M8 ? ? 'expression tag' 535 15 
2 9J9J HIS B 536 ? UNP Q6F4M8 ? ? 'expression tag' 536 16 
3 9J9J LEU C 529 ? UNP Q6F4M8 ? ? 'expression tag' 529 17 
3 9J9J GLU C 530 ? UNP Q6F4M8 ? ? 'expression tag' 530 18 
3 9J9J HIS C 531 ? UNP Q6F4M8 ? ? 'expression tag' 531 19 
3 9J9J HIS C 532 ? UNP Q6F4M8 ? ? 'expression tag' 532 20 
3 9J9J HIS C 533 ? UNP Q6F4M8 ? ? 'expression tag' 533 21 
3 9J9J HIS C 534 ? UNP Q6F4M8 ? ? 'expression tag' 534 22 
3 9J9J HIS C 535 ? UNP Q6F4M8 ? ? 'expression tag' 535 23 
3 9J9J HIS C 536 ? UNP Q6F4M8 ? ? 'expression tag' 536 24 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_and_software_defined_assembly PISA tetrameric 4 
2 author_and_software_defined_assembly PISA tetrameric 4 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 23960 ? 
1 MORE         -196  ? 
1 'SSA (A^2)'  65040 ? 
2 'ABSA (A^2)' 22710 ? 
2 MORE         -196  ? 
2 'SSA (A^2)'  64470 ? 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1,2,3,5 A,D     
2 1,4     B,C,E,F 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555  x,y,z     1.0000000000  0.0000000000  0.0000000000 0.0000000000 0.0000000000  1.0000000000  
0.0000000000 0.0000000000   0.0000000000 0.0000000000 1.0000000000  0.0000000000 
2 'crystal symmetry operation' 8_555  -y,-x,-z  0.0000000000  -1.0000000000 0.0000000000 0.0000000000 -1.0000000000 0.0000000000  
0.0000000000 0.0000000000   0.0000000000 0.0000000000 -1.0000000000 0.0000000000 
3 'crystal symmetry operation' 10_555 -x,-y,z   -1.0000000000 0.0000000000  0.0000000000 0.0000000000 0.0000000000  -1.0000000000 
0.0000000000 0.0000000000   0.0000000000 0.0000000000 1.0000000000  0.0000000000 
4 'crystal symmetry operation' 10_565 -x,-y+1,z -1.0000000000 0.0000000000  0.0000000000 0.0000000000 0.0000000000  -1.0000000000 
0.0000000000 149.5610000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000 
5 'crystal symmetry operation' 15_555 y,x,-z    0.0000000000  1.0000000000  0.0000000000 0.0000000000 1.0000000000  0.0000000000  
0.0000000000 0.0000000000   0.0000000000 0.0000000000 -1.0000000000 0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 THR A 3   ? ARG A 12  ? THR A 3   ARG A 12  1 ? 10 
HELX_P HELX_P2  AA2 THR A 33  ? ASP A 49  ? THR A 33  ASP A 49  1 ? 17 
HELX_P HELX_P3  AA3 HIS A 52  ? LEU A 56  ? HIS A 52  LEU A 56  1 ? 5  
HELX_P HELX_P4  AA4 HIS A 69  ? PHE A 71  ? HIS A 69  PHE A 71  5 ? 3  
HELX_P HELX_P5  AA5 SER A 75  ? PHE A 93  ? SER A 75  PHE A 93  1 ? 19 
HELX_P HELX_P6  AA6 PRO A 101 ? HIS A 106 ? PRO A 101 HIS A 106 1 ? 6  
HELX_P HELX_P7  AA7 MET A 109 ? ASP A 115 ? MET A 109 ASP A 115 1 ? 7  
HELX_P HELX_P8  AA8 PRO A 116 ? ASN A 122 ? PRO A 116 ASN A 122 1 ? 7  
HELX_P HELX_P9  AA9 SER A 132 ? ASP A 148 ? SER A 132 ASP A 148 1 ? 17 
HELX_P HELX_P10 AB1 LEU A 196 ? VAL A 199 ? LEU A 196 VAL A 199 5 ? 4  
HELX_P HELX_P11 AB2 ASP A 279 ? GLY A 319 ? ASP A 279 GLY A 319 1 ? 41 
HELX_P HELX_P12 AB3 ASN A 323 ? THR A 350 ? ASN A 323 THR A 350 1 ? 28 
HELX_P HELX_P13 AB4 ASN A 362 ? GLY A 389 ? ASN A 362 GLY A 389 1 ? 28 
HELX_P HELX_P14 AB5 ARG A 390 ? VAL A 393 ? ARG A 390 VAL A 393 5 ? 4  
HELX_P HELX_P15 AB6 THR A 397 ? HIS A 403 ? THR A 397 HIS A 403 1 ? 7  
HELX_P HELX_P16 AB7 PHE A 405 ? LEU A 414 ? PHE A 405 LEU A 414 1 ? 10 
HELX_P HELX_P17 AB8 SER A 420 ? LEU A 436 ? SER A 420 LEU A 436 1 ? 17 
HELX_P HELX_P18 AB9 THR A 437 ? ASN A 450 ? THR A 437 ASN A 450 1 ? 14 
HELX_P HELX_P19 AC1 PRO A 453 ? ARG A 464 ? PRO A 453 ARG A 464 1 ? 12 
HELX_P HELX_P20 AC2 THR A 465 ? GLN A 468 ? THR A 465 GLN A 468 5 ? 4  
HELX_P HELX_P21 AC3 GLY A 471 ? LEU A 473 ? GLY A 471 LEU A 473 5 ? 3  
HELX_P HELX_P22 AC4 THR A 474 ? GLY A 482 ? THR A 474 GLY A 482 1 ? 9  
HELX_P HELX_P23 AC5 ASP A 485 ? ASN A 499 ? ASP A 485 ASN A 499 1 ? 15 
HELX_P HELX_P24 AC6 THR B 3   ? LEU B 11  ? THR B 3   LEU B 11  1 ? 9  
HELX_P HELX_P25 AC7 THR B 33  ? ASP B 49  ? THR B 33  ASP B 49  1 ? 17 
HELX_P HELX_P26 AC8 HIS B 52  ? LEU B 56  ? HIS B 52  LEU B 56  1 ? 5  
HELX_P HELX_P27 AC9 HIS B 69  ? PHE B 71  ? HIS B 69  PHE B 71  5 ? 3  
HELX_P HELX_P28 AD1 SER B 75  ? PHE B 93  ? SER B 75  PHE B 93  1 ? 19 
HELX_P HELX_P29 AD2 PRO B 101 ? HIS B 106 ? PRO B 101 HIS B 106 1 ? 6  
HELX_P HELX_P30 AD3 MET B 109 ? ASP B 115 ? MET B 109 ASP B 115 1 ? 7  
HELX_P HELX_P31 AD4 PRO B 116 ? ASN B 122 ? PRO B 116 ASN B 122 1 ? 7  
HELX_P HELX_P32 AD5 SER B 132 ? ASP B 148 ? SER B 132 ASP B 148 1 ? 17 
HELX_P HELX_P33 AD6 LEU B 196 ? VAL B 199 ? LEU B 196 VAL B 199 5 ? 4  
HELX_P HELX_P34 AD7 ASP B 279 ? LEU B 318 ? ASP B 279 LEU B 318 1 ? 40 
HELX_P HELX_P35 AD8 ASN B 323 ? THR B 350 ? ASN B 323 THR B 350 1 ? 28 
HELX_P HELX_P36 AD9 ASN B 362 ? GLY B 389 ? ASN B 362 GLY B 389 1 ? 28 
HELX_P HELX_P37 AE1 ARG B 390 ? VAL B 393 ? ARG B 390 VAL B 393 5 ? 4  
HELX_P HELX_P38 AE2 THR B 397 ? HIS B 403 ? THR B 397 HIS B 403 1 ? 7  
HELX_P HELX_P39 AE3 PHE B 405 ? LEU B 414 ? PHE B 405 LEU B 414 1 ? 10 
HELX_P HELX_P40 AE4 SER B 420 ? LEU B 436 ? SER B 420 LEU B 436 1 ? 17 
HELX_P HELX_P41 AE5 THR B 437 ? PHE B 449 ? THR B 437 PHE B 449 1 ? 13 
HELX_P HELX_P42 AE6 PRO B 453 ? ARG B 464 ? PRO B 453 ARG B 464 1 ? 12 
HELX_P HELX_P43 AE7 THR B 465 ? GLN B 468 ? THR B 465 GLN B 468 5 ? 4  
HELX_P HELX_P44 AE8 GLY B 471 ? LEU B 473 ? GLY B 471 LEU B 473 5 ? 3  
HELX_P HELX_P45 AE9 THR B 474 ? GLY B 482 ? THR B 474 GLY B 482 1 ? 9  
HELX_P HELX_P46 AF1 ASP B 485 ? ASN B 499 ? ASP B 485 ASN B 499 1 ? 15 
HELX_P HELX_P47 AF2 THR C 3   ? LEU C 11  ? THR C 3   LEU C 11  1 ? 9  
HELX_P HELX_P48 AF3 THR C 33  ? ASP C 49  ? THR C 33  ASP C 49  1 ? 17 
HELX_P HELX_P49 AF4 HIS C 52  ? LEU C 56  ? HIS C 52  LEU C 56  1 ? 5  
HELX_P HELX_P50 AF5 HIS C 69  ? PHE C 71  ? HIS C 69  PHE C 71  5 ? 3  
HELX_P HELX_P51 AF6 SER C 75  ? PHE C 93  ? SER C 75  PHE C 93  1 ? 19 
HELX_P HELX_P52 AF7 PRO C 101 ? HIS C 106 ? PRO C 101 HIS C 106 1 ? 6  
HELX_P HELX_P53 AF8 VAL C 108 ? ASP C 115 ? VAL C 108 ASP C 115 1 ? 8  
HELX_P HELX_P54 AF9 PRO C 116 ? ASN C 122 ? PRO C 116 ASN C 122 1 ? 7  
HELX_P HELX_P55 AG1 SER C 132 ? ASP C 148 ? SER C 132 ASP C 148 1 ? 17 
HELX_P HELX_P56 AG2 LEU C 196 ? VAL C 199 ? LEU C 196 VAL C 199 5 ? 4  
HELX_P HELX_P57 AG3 ASP C 279 ? GLY C 319 ? ASP C 279 GLY C 319 1 ? 41 
HELX_P HELX_P58 AG4 ASN C 323 ? THR C 350 ? ASN C 323 THR C 350 1 ? 28 
HELX_P HELX_P59 AG5 ASN C 362 ? GLY C 389 ? ASN C 362 GLY C 389 1 ? 28 
HELX_P HELX_P60 AG6 ARG C 390 ? SER C 395 ? ARG C 390 SER C 395 1 ? 6  
HELX_P HELX_P61 AG7 THR C 397 ? HIS C 403 ? THR C 397 HIS C 403 1 ? 7  
HELX_P HELX_P62 AG8 PHE C 405 ? LEU C 414 ? PHE C 405 LEU C 414 1 ? 10 
HELX_P HELX_P63 AG9 SER C 420 ? LEU C 436 ? SER C 420 LEU C 436 1 ? 17 
HELX_P HELX_P64 AH1 THR C 437 ? ASN C 450 ? THR C 437 ASN C 450 1 ? 14 
HELX_P HELX_P65 AH2 PRO C 453 ? MET C 462 ? PRO C 453 MET C 462 1 ? 10 
HELX_P HELX_P66 AH3 GLN C 463 ? GLN C 468 ? GLN C 463 GLN C 468 5 ? 6  
HELX_P HELX_P67 AH4 GLY C 471 ? LEU C 473 ? GLY C 471 LEU C 473 5 ? 3  
HELX_P HELX_P68 AH5 THR C 474 ? GLY C 482 ? THR C 474 GLY C 482 1 ? 9  
HELX_P HELX_P69 AH6 ASP C 485 ? LYS C 498 ? ASP C 485 LYS C 498 1 ? 14 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 6 ? 
AA2 ? 2 ? 
AA3 ? 4 ? 
AA4 ? 2 ? 
AA5 ? 6 ? 
AA6 ? 2 ? 
AA7 ? 4 ? 
AA8 ? 2 ? 
AA9 ? 6 ? 
AB1 ? 2 ? 
AB2 ? 4 ? 
AB3 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? parallel      
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? parallel      
AA5 3 4 ? anti-parallel 
AA5 4 5 ? anti-parallel 
AA5 5 6 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA7 1 2 ? parallel      
AA7 2 3 ? anti-parallel 
AA7 3 4 ? anti-parallel 
AA8 1 2 ? anti-parallel 
AA9 1 2 ? anti-parallel 
AA9 2 3 ? parallel      
AA9 3 4 ? anti-parallel 
AA9 4 5 ? anti-parallel 
AA9 5 6 ? anti-parallel 
AB1 1 2 ? anti-parallel 
AB2 1 2 ? parallel      
AB2 2 3 ? anti-parallel 
AB2 3 4 ? anti-parallel 
AB3 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 GLU A 22  ? LEU A 23  ? GLU A 22  LEU A 23  
AA1 2 GLN A 16  ? VAL A 19  ? GLN A 16  VAL A 19  
AA1 3 LEU A 229 ? CYS A 233 ? LEU A 229 CYS A 233 
AA1 4 ASP A 257 ? PRO A 268 ? ASP A 257 PRO A 268 
AA1 5 GLY A 183 ? THR A 194 ? GLY A 183 THR A 194 
AA1 6 SER A 175 ? GLN A 179 ? SER A 175 GLN A 179 
AA2 1 THR A 57  ? VAL A 59  ? THR A 57  VAL A 59  
AA2 2 ARG A 65  ? SER A 67  ? ARG A 65  SER A 67  
AA3 1 LEU A 151 ? MET A 154 ? LEU A 151 MET A 154 
AA3 2 GLU A 201 ? VAL A 204 ? GLU A 201 VAL A 204 
AA3 3 VAL A 218 ? PRO A 223 ? VAL A 218 PRO A 223 
AA3 4 VAL A 272 ? ILE A 275 ? VAL A 272 ILE A 275 
AA4 1 PHE A 352 ? THR A 353 ? PHE A 352 THR A 353 
AA4 2 PHE A 359 ? LYS A 360 ? PHE A 359 LYS A 360 
AA5 1 GLU B 22  ? ILE B 24  ? GLU B 22  ILE B 24  
AA5 2 GLN B 16  ? VAL B 19  ? GLN B 16  VAL B 19  
AA5 3 LEU B 229 ? CYS B 233 ? LEU B 229 CYS B 233 
AA5 4 ASP B 257 ? PRO B 268 ? ASP B 257 PRO B 268 
AA5 5 GLY B 183 ? THR B 194 ? GLY B 183 THR B 194 
AA5 6 SER B 175 ? GLN B 179 ? SER B 175 GLN B 179 
AA6 1 THR B 57  ? VAL B 59  ? THR B 57  VAL B 59  
AA6 2 ARG B 65  ? SER B 67  ? ARG B 65  SER B 67  
AA7 1 LEU B 151 ? MET B 154 ? LEU B 151 MET B 154 
AA7 2 GLU B 201 ? VAL B 204 ? GLU B 201 VAL B 204 
AA7 3 VAL B 218 ? PRO B 223 ? VAL B 218 PRO B 223 
AA7 4 VAL B 272 ? ILE B 275 ? VAL B 272 ILE B 275 
AA8 1 PHE B 352 ? THR B 353 ? PHE B 352 THR B 353 
AA8 2 PHE B 359 ? LYS B 360 ? PHE B 359 LYS B 360 
AA9 1 GLU C 22  ? LEU C 23  ? GLU C 22  LEU C 23  
AA9 2 GLN C 16  ? VAL C 19  ? GLN C 16  VAL C 19  
AA9 3 LEU C 229 ? CYS C 233 ? LEU C 229 CYS C 233 
AA9 4 ASP C 257 ? PRO C 268 ? ASP C 257 PRO C 268 
AA9 5 GLY C 183 ? THR C 194 ? GLY C 183 THR C 194 
AA9 6 SER C 175 ? GLN C 179 ? SER C 175 GLN C 179 
AB1 1 THR C 57  ? VAL C 59  ? THR C 57  VAL C 59  
AB1 2 ARG C 65  ? SER C 67  ? ARG C 65  SER C 67  
AB2 1 LEU C 151 ? MET C 154 ? LEU C 151 MET C 154 
AB2 2 GLU C 201 ? VAL C 204 ? GLU C 201 VAL C 204 
AB2 3 VAL C 218 ? PRO C 223 ? VAL C 218 PRO C 223 
AB2 4 VAL C 272 ? ILE C 275 ? VAL C 272 ILE C 275 
AB3 1 PHE C 352 ? THR C 353 ? PHE C 352 THR C 353 
AB3 2 PHE C 359 ? LYS C 360 ? PHE C 359 LYS C 360 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O GLU A 22  ? O GLU A 22  N VAL A 19  ? N VAL A 19  
AA1 2 3 N TYR A 18  ? N TYR A 18  O CYS A 233 ? O CYS A 233 
AA1 3 4 N SER A 230 ? N SER A 230 O TYR A 261 ? O TYR A 261 
AA1 4 5 O ILE A 267 ? O ILE A 267 N ILE A 184 ? N ILE A 184 
AA1 5 6 O VAL A 185 ? O VAL A 185 N VAL A 177 ? N VAL A 177 
AA2 1 2 N PHE A 58  ? N PHE A 58  O LYS A 66  ? O LYS A 66  
AA3 1 2 N MET A 154 ? N MET A 154 O LEU A 203 ? O LEU A 203 
AA3 2 3 N VAL A 204 ? N VAL A 204 O ALA A 220 ? O ALA A 220 
AA3 3 4 N TYR A 219 ? N TYR A 219 O GLN A 273 ? O GLN A 273 
AA4 1 2 N PHE A 352 ? N PHE A 352 O LYS A 360 ? O LYS A 360 
AA5 1 2 O ILE B 24  ? O ILE B 24  N VAL B 17  ? N VAL B 17  
AA5 2 3 N TYR B 18  ? N TYR B 18  O CYS B 233 ? O CYS B 233 
AA5 3 4 N SER B 230 ? N SER B 230 O TYR B 261 ? O TYR B 261 
AA5 4 5 O ILE B 267 ? O ILE B 267 N ILE B 184 ? N ILE B 184 
AA5 5 6 O ARG B 187 ? O ARG B 187 N SER B 175 ? N SER B 175 
AA6 1 2 N PHE B 58  ? N PHE B 58  O LYS B 66  ? O LYS B 66  
AA7 1 2 N MET B 154 ? N MET B 154 O LEU B 203 ? O LEU B 203 
AA7 2 3 N LEU B 202 ? N LEU B 202 O VAL B 222 ? O VAL B 222 
AA7 3 4 N TYR B 219 ? N TYR B 219 O GLN B 273 ? O GLN B 273 
AA8 1 2 N PHE B 352 ? N PHE B 352 O LYS B 360 ? O LYS B 360 
AA9 1 2 O GLU C 22  ? O GLU C 22  N VAL C 19  ? N VAL C 19  
AA9 2 3 N TYR C 18  ? N TYR C 18  O CYS C 233 ? O CYS C 233 
AA9 3 4 N VAL C 232 ? N VAL C 232 O MET C 259 ? O MET C 259 
AA9 4 5 O PHE C 262 ? O PHE C 262 N GLY C 188 ? N GLY C 188 
AA9 5 6 O VAL C 185 ? O VAL C 185 N VAL C 177 ? N VAL C 177 
AB1 1 2 N PHE C 58  ? N PHE C 58  O LYS C 66  ? O LYS C 66  
AB2 1 2 N SER C 152 ? N SER C 152 O LEU C 203 ? O LEU C 203 
AB2 2 3 N LEU C 202 ? N LEU C 202 O VAL C 222 ? O VAL C 222 
AB2 3 4 N TYR C 219 ? N TYR C 219 O GLN C 273 ? O GLN C 273 
AB3 1 2 N PHE C 352 ? N PHE C 352 O LYS C 360 ? O LYS C 360 
# 
_pdbx_entry_details.entry_id                   9J9J 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 O A HOH 634 ? ? O A HOH 645 ? ? 2.10 
2 1 O A HOH 646 ? ? O A HOH 664 ? ? 2.13 
3 1 O B HOH 626 ? ? O C HOH 617 ? ? 2.15 
4 1 O C HOH 612 ? ? O C HOH 615 ? ? 2.19 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1 1 NE A ARG 370 ? ? CZ A ARG 370 ? ? NH2 A ARG 370 ? ? 116.43 120.30 -3.87 0.50 N 
2 1 CG C MET 1   ? ? SD C MET 1   ? ? CE  C MET 1   ? ? 111.97 100.20 11.77 1.60 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ASP A 62  ? ? -55.08  -0.86  
2  1 ARG A 100 ? ? -144.62 56.91  
3  1 GLN A 159 ? ? -60.96  -71.10 
4  1 HIS A 274 ? ? -173.46 144.53 
5  1 ASP B 62  ? ? -68.54  3.63   
6  1 GLN B 94  ? ? 61.44   61.36  
7  1 GLU B 255 ? ? -67.20  91.25  
8  1 HIS B 274 ? ? -177.38 143.10 
9  1 PHE C 93  ? ? -94.32  34.30  
10 1 PRO C 361 ? ? -39.39  144.61 
11 1 LEU C 436 ? ? -141.57 30.63  
# 
_pdbx_validate_peptide_omega.id               1 
_pdbx_validate_peptide_omega.PDB_model_num    1 
_pdbx_validate_peptide_omega.auth_comp_id_1   MET 
_pdbx_validate_peptide_omega.auth_asym_id_1   C 
_pdbx_validate_peptide_omega.auth_seq_id_1    394 
_pdbx_validate_peptide_omega.PDB_ins_code_1   ? 
_pdbx_validate_peptide_omega.label_alt_id_1   ? 
_pdbx_validate_peptide_omega.auth_comp_id_2   SER 
_pdbx_validate_peptide_omega.auth_asym_id_2   C 
_pdbx_validate_peptide_omega.auth_seq_id_2    395 
_pdbx_validate_peptide_omega.PDB_ins_code_2   ? 
_pdbx_validate_peptide_omega.label_alt_id_2   ? 
_pdbx_validate_peptide_omega.omega            -146.43 
# 
loop_
_pdbx_validate_planes.id 
_pdbx_validate_planes.PDB_model_num 
_pdbx_validate_planes.auth_comp_id 
_pdbx_validate_planes.auth_asym_id 
_pdbx_validate_planes.auth_seq_id 
_pdbx_validate_planes.PDB_ins_code 
_pdbx_validate_planes.label_alt_id 
_pdbx_validate_planes.rmsd 
_pdbx_validate_planes.type 
1 1 ARG A 82  ? ? 0.074 'SIDE CHAIN' 
2 1 ARG A 492 ? ? 0.112 'SIDE CHAIN' 
3 1 ARG B 82  ? ? 0.086 'SIDE CHAIN' 
4 1 ARG B 492 ? ? 0.093 'SIDE CHAIN' 
5 1 ARG C 83  ? ? 0.107 'SIDE CHAIN' 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A ASP 161 ? A ASP 161 
2   1 Y 1 A ARG 162 ? A ARG 162 
3   1 Y 1 A GLY 163 ? A GLY 163 
4   1 Y 1 A ARG 164 ? A ARG 164 
5   1 Y 1 A ASP 165 ? A ASP 165 
6   1 Y 1 A ASP 166 ? A ASP 166 
7   1 Y 1 A ALA 167 ? A ALA 167 
8   1 Y 1 A LEU 168 ? A LEU 168 
9   1 Y 1 A VAL 169 ? A VAL 169 
10  1 Y 1 A ALA 503 ? A ALA 503 
11  1 Y 1 A SER 504 ? A SER 504 
12  1 Y 1 A VAL 505 ? A VAL 505 
13  1 Y 1 A ALA 506 ? A ALA 506 
14  1 Y 1 A TYR 507 ? A TYR 507 
15  1 Y 1 A GLN 508 ? A GLN 508 
16  1 Y 1 A PRO 509 ? A PRO 509 
17  1 Y 1 A GLU 510 ? A GLU 510 
18  1 Y 1 A TYR 511 ? A TYR 511 
19  1 Y 1 A ALA 512 ? A ALA 512 
20  1 Y 1 A ARG 513 ? A ARG 513 
21  1 Y 1 A GLU 514 ? A GLU 514 
22  1 Y 1 A GLN 515 ? A GLN 515 
23  1 Y 1 A ASP 516 ? A ASP 516 
24  1 Y 1 A VAL 517 ? A VAL 517 
25  1 Y 1 A ARG 518 ? A ARG 518 
26  1 Y 1 A ASP 519 ? A ASP 519 
27  1 Y 1 A GLY 520 ? A GLY 520 
28  1 Y 1 A TYR 521 ? A TYR 521 
29  1 Y 1 A TYR 522 ? A TYR 522 
30  1 Y 1 A LYS 523 ? A LYS 523 
31  1 Y 1 A GLU 524 ? A GLU 524 
32  1 Y 1 A THR 525 ? A THR 525 
33  1 Y 1 A GLU 526 ? A GLU 526 
34  1 Y 1 A LYS 527 ? A LYS 527 
35  1 Y 1 A VAL 528 ? A VAL 528 
36  1 Y 1 A LEU 529 ? A LEU 529 
37  1 Y 1 A GLU 530 ? A GLU 530 
38  1 Y 1 A HIS 531 ? A HIS 531 
39  1 Y 1 A HIS 532 ? A HIS 532 
40  1 Y 1 A HIS 533 ? A HIS 533 
41  1 Y 1 A HIS 534 ? A HIS 534 
42  1 Y 1 A HIS 535 ? A HIS 535 
43  1 Y 1 A HIS 536 ? A HIS 536 
44  1 Y 1 B ASP 161 ? B ASP 161 
45  1 Y 1 B ARG 162 ? B ARG 162 
46  1 Y 1 B GLY 163 ? B GLY 163 
47  1 Y 1 B ARG 164 ? B ARG 164 
48  1 Y 1 B ASP 165 ? B ASP 165 
49  1 Y 1 B ASP 166 ? B ASP 166 
50  1 Y 1 B ALA 167 ? B ALA 167 
51  1 Y 1 B LEU 168 ? B LEU 168 
52  1 Y 1 B VAL 169 ? B VAL 169 
53  1 Y 1 B ASN 501 ? B ASN 501 
54  1 Y 1 B TRP 502 ? B TRP 502 
55  1 Y 1 B ALA 503 ? B ALA 503 
56  1 Y 1 B SER 504 ? B SER 504 
57  1 Y 1 B VAL 505 ? B VAL 505 
58  1 Y 1 B ALA 506 ? B ALA 506 
59  1 Y 1 B TYR 507 ? B TYR 507 
60  1 Y 1 B GLN 508 ? B GLN 508 
61  1 Y 1 B PRO 509 ? B PRO 509 
62  1 Y 1 B GLU 510 ? B GLU 510 
63  1 Y 1 B TYR 511 ? B TYR 511 
64  1 Y 1 B ALA 512 ? B ALA 512 
65  1 Y 1 B ARG 513 ? B ARG 513 
66  1 Y 1 B GLU 514 ? B GLU 514 
67  1 Y 1 B GLN 515 ? B GLN 515 
68  1 Y 1 B ASP 516 ? B ASP 516 
69  1 Y 1 B VAL 517 ? B VAL 517 
70  1 Y 1 B ARG 518 ? B ARG 518 
71  1 Y 1 B ASP 519 ? B ASP 519 
72  1 Y 1 B GLY 520 ? B GLY 520 
73  1 Y 1 B TYR 521 ? B TYR 521 
74  1 Y 1 B TYR 522 ? B TYR 522 
75  1 Y 1 B LYS 523 ? B LYS 523 
76  1 Y 1 B GLU 524 ? B GLU 524 
77  1 Y 1 B THR 525 ? B THR 525 
78  1 Y 1 B GLU 526 ? B GLU 526 
79  1 Y 1 B LYS 527 ? B LYS 527 
80  1 Y 1 B VAL 528 ? B VAL 528 
81  1 Y 1 B LEU 529 ? B LEU 529 
82  1 Y 1 B GLU 530 ? B GLU 530 
83  1 Y 1 B HIS 531 ? B HIS 531 
84  1 Y 1 B HIS 532 ? B HIS 532 
85  1 Y 1 B HIS 533 ? B HIS 533 
86  1 Y 1 B HIS 534 ? B HIS 534 
87  1 Y 1 B HIS 535 ? B HIS 535 
88  1 Y 1 B HIS 536 ? B HIS 536 
89  1 Y 1 C GLN 159 ? C GLN 159 
90  1 Y 1 C PHE 160 ? C PHE 160 
91  1 Y 1 C ASP 161 ? C ASP 161 
92  1 Y 1 C ARG 162 ? C ARG 162 
93  1 Y 1 C GLY 163 ? C GLY 163 
94  1 Y 1 C ARG 164 ? C ARG 164 
95  1 Y 1 C ASP 165 ? C ASP 165 
96  1 Y 1 C ASP 166 ? C ASP 166 
97  1 Y 1 C ALA 167 ? C ALA 167 
98  1 Y 1 C LEU 168 ? C LEU 168 
99  1 Y 1 C VAL 169 ? C VAL 169 
100 1 Y 1 C ASN 499 ? C ASN 499 
101 1 Y 1 C SER 500 ? C SER 500 
102 1 Y 1 C ASN 501 ? C ASN 501 
103 1 Y 1 C TRP 502 ? C TRP 502 
104 1 Y 1 C ALA 503 ? C ALA 503 
105 1 Y 1 C SER 504 ? C SER 504 
106 1 Y 1 C VAL 505 ? C VAL 505 
107 1 Y 1 C ALA 506 ? C ALA 506 
108 1 Y 1 C TYR 507 ? C TYR 507 
109 1 Y 1 C GLN 508 ? C GLN 508 
110 1 Y 1 C PRO 509 ? C PRO 509 
111 1 Y 1 C GLU 510 ? C GLU 510 
112 1 Y 1 C TYR 511 ? C TYR 511 
113 1 Y 1 C ALA 512 ? C ALA 512 
114 1 Y 1 C ARG 513 ? C ARG 513 
115 1 Y 1 C GLU 514 ? C GLU 514 
116 1 Y 1 C GLN 515 ? C GLN 515 
117 1 Y 1 C ASP 516 ? C ASP 516 
118 1 Y 1 C VAL 517 ? C VAL 517 
119 1 Y 1 C ARG 518 ? C ARG 518 
120 1 Y 1 C ASP 519 ? C ASP 519 
121 1 Y 1 C GLY 520 ? C GLY 520 
122 1 Y 1 C TYR 521 ? C TYR 521 
123 1 Y 1 C TYR 522 ? C TYR 522 
124 1 Y 1 C LYS 523 ? C LYS 523 
125 1 Y 1 C GLU 524 ? C GLU 524 
126 1 Y 1 C THR 525 ? C THR 525 
127 1 Y 1 C GLU 526 ? C GLU 526 
128 1 Y 1 C LYS 527 ? C LYS 527 
129 1 Y 1 C VAL 528 ? C VAL 528 
130 1 Y 1 C LEU 529 ? C LEU 529 
131 1 Y 1 C GLU 530 ? C GLU 530 
132 1 Y 1 C HIS 531 ? C HIS 531 
133 1 Y 1 C HIS 532 ? C HIS 532 
134 1 Y 1 C HIS 533 ? C HIS 533 
135 1 Y 1 C HIS 534 ? C HIS 534 
136 1 Y 1 C HIS 535 ? C HIS 535 
137 1 Y 1 C HIS 536 ? C HIS 536 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'in silico model' 
_pdbx_initial_refinement_model.source_name      AlphaFold 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9J9J 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.006686 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.006686 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.003104 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1     N N   . MET A 1 1   ? 31.864  21.139  -32.173 1.00 41.41  ? 1   MET A N   1 
ATOM   2     C CA  . MET A 1 1   ? 30.415  20.836  -32.017 1.00 45.67  ? 1   MET A CA  1 
ATOM   3     C C   . MET A 1 1   ? 29.815  20.583  -33.391 1.00 45.86  ? 1   MET A C   1 
ATOM   4     O O   . MET A 1 1   ? 29.978  21.414  -34.261 1.00 47.01  ? 1   MET A O   1 
ATOM   5     C CB  . MET A 1 1   ? 29.681  22.003  -31.362 1.00 42.37  ? 1   MET A CB  1 
ATOM   6     C CG  . MET A 1 1   ? 30.208  22.350  -29.996 1.00 40.79  ? 1   MET A CG  1 
ATOM   7     S SD  . MET A 1 1   ? 29.463  23.850  -29.329 1.00 53.85  ? 1   MET A SD  1 
ATOM   8     C CE  . MET A 1 1   ? 27.756  23.302  -29.308 1.00 55.77  ? 1   MET A CE  1 
ATOM   9     N N   . ARG A 1 2   ? 29.185  19.420  -33.592 1.00 44.88  ? 2   ARG A N   1 
ATOM   10    C CA  . ARG A 1 2   ? 28.633  19.068  -34.889 1.00 41.96  ? 2   ARG A CA  1 
ATOM   11    C C   . ARG A 1 2   ? 27.250  19.688  -35.086 1.00 41.74  ? 2   ARG A C   1 
ATOM   12    O O   . ARG A 1 2   ? 26.562  20.033  -34.128 1.00 45.08  ? 2   ARG A O   1 
ATOM   13    C CB  . ARG A 1 2   ? 28.516  17.555  -35.115 1.00 43.45  ? 2   ARG A CB  1 
ATOM   14    C CG  . ARG A 1 2   ? 29.842  16.858  -35.387 1.00 46.66  ? 2   ARG A CG  1 
ATOM   15    C CD  . ARG A 1 2   ? 29.681  15.388  -35.766 1.00 49.06  ? 2   ARG A CD  1 
ATOM   16    N NE  . ARG A 1 2   ? 28.983  14.620  -34.725 1.00 44.48  ? 2   ARG A NE  1 
ATOM   17    C CZ  . ARG A 1 2   ? 28.544  13.397  -34.887 1.00 42.45  ? 2   ARG A CZ  1 
ATOM   18    N NH1 . ARG A 1 2   ? 28.585  12.831  -36.075 1.00 41.51  ? 2   ARG A NH1 1 
ATOM   19    N NH2 . ARG A 1 2   ? 28.042  12.740  -33.863 1.00 48.67  ? 2   ARG A NH2 1 
ATOM   20    N N   . THR A 1 3   ? 26.879  19.806  -36.369 1.00 39.97  ? 3   THR A N   1 
ATOM   21    C CA  . THR A 1 3   ? 25.557  20.222  -36.798 1.00 40.23  ? 3   THR A CA  1 
ATOM   22    C C   . THR A 1 3   ? 24.650  19.002  -36.890 1.00 40.75  ? 3   THR A C   1 
ATOM   23    O O   . THR A 1 3   ? 25.103  17.883  -37.148 1.00 41.06  ? 3   THR A O   1 
ATOM   24    C CB  . THR A 1 3   ? 25.619  20.881  -38.182 1.00 42.73  ? 3   THR A CB  1 
ATOM   25    O OG1 . THR A 1 3   ? 26.013  19.793  -39.014 1.00 43.21  ? 3   THR A OG1 1 
ATOM   26    C CG2 . THR A 1 3   ? 26.562  22.070  -38.285 1.00 39.06  ? 3   THR A CG2 1 
ATOM   27    N N   . GLY A 1 4   ? 23.349  19.272  -36.844 1.00 40.31  ? 4   GLY A N   1 
ATOM   28    C CA  . GLY A 1 4   ? 22.353  18.278  -37.192 1.00 40.44  ? 4   GLY A CA  1 
ATOM   29    C C   . GLY A 1 4   ? 22.680  17.595  -38.513 1.00 37.46  ? 4   GLY A C   1 
ATOM   30    O O   . GLY A 1 4   ? 22.690  16.365  -38.586 1.00 36.88  ? 4   GLY A O   1 
ATOM   31    N N   . GLN A 1 5   ? 22.986  18.382  -39.550 1.00 42.19  ? 5   GLN A N   1 
ATOM   32    C CA  . GLN A 1 5   ? 23.290  17.782  -40.847 1.00 47.56  ? 5   GLN A CA  1 
ATOM   33    C C   . GLN A 1 5   ? 24.515  16.878  -40.738 1.00 38.31  ? 5   GLN A C   1 
ATOM   34    O O   . GLN A 1 5   ? 24.524  15.778  -41.296 1.00 40.14  ? 5   GLN A O   1 
ATOM   35    C CB  . GLN A 1 5   ? 23.475  18.745  -42.025 1.00 54.59  ? 5   GLN A CB  1 
ATOM   36    C CG  . GLN A 1 5   ? 22.824  18.275  -43.330 1.00 64.79  ? 5   GLN A CG  1 
ATOM   37    C CD  . GLN A 1 5   ? 21.344  17.922  -43.206 1.00 77.89  ? 5   GLN A CD  1 
ATOM   38    O OE1 . GLN A 1 5   ? 20.585  18.513  -42.424 1.00 74.74  ? 5   GLN A OE1 1 
ATOM   39    N NE2 . GLN A 1 5   ? 20.900  16.925  -43.960 1.00 76.89  ? 5   GLN A NE2 1 
ATOM   40    N N   . GLN A 1 6   ? 25.541  17.294  -39.993 1.00 41.51  ? 6   GLN A N   1 
ATOM   41    C CA  . GLN A 1 6   ? 26.727  16.447  -39.905 1.00 42.57  ? 6   GLN A CA  1 
ATOM   42    C C   . GLN A 1 6   ? 26.373  15.170  -39.155 1.00 37.66  ? 6   GLN A C   1 
ATOM   43    O O   . GLN A 1 6   ? 26.829  14.094  -39.530 1.00 38.44  ? 6   GLN A O   1 
ATOM   44    C CB  . GLN A 1 6   ? 27.948  17.118  -39.286 1.00 44.31  ? 6   GLN A CB  1 
ATOM   45    C CG  . GLN A 1 6   ? 28.464  18.305  -40.095 1.00 44.52  ? 6   GLN A CG  1 
ATOM   46    C CD  . GLN A 1 6   ? 29.317  19.248  -39.274 1.00 48.22  ? 6   GLN A CD  1 
ATOM   47    O OE1 . GLN A 1 6   ? 28.940  19.676  -38.175 1.00 55.75  ? 6   GLN A OE1 1 
ATOM   48    N NE2 . GLN A 1 6   ? 30.481  19.586  -39.793 1.00 44.77  ? 6   GLN A NE2 1 
ATOM   49    N N   . TYR A 1 7   ? 25.492  15.291  -38.150 1.00 39.38  ? 7   TYR A N   1 
ATOM   50    C CA  . TYR A 1 7   ? 25.070  14.141  -37.366 1.00 38.76  ? 7   TYR A CA  1 
ATOM   51    C C   . TYR A 1 7   ? 24.303  13.180  -38.260 1.00 39.17  ? 7   TYR A C   1 
ATOM   52    O O   . TYR A 1 7   ? 24.555  11.983  -38.238 1.00 43.65  ? 7   TYR A O   1 
ATOM   53    C CB  . TYR A 1 7   ? 24.234  14.537  -36.146 1.00 43.68  ? 7   TYR A CB  1 
ATOM   54    C CG  . TYR A 1 7   ? 23.410  13.386  -35.583 1.00 37.47  ? 7   TYR A CG  1 
ATOM   55    C CD1 . TYR A 1 7   ? 24.019  12.396  -34.848 1.00 36.20  ? 7   TYR A CD1 1 
ATOM   56    C CD2 . TYR A 1 7   ? 22.048  13.277  -35.819 1.00 34.83  ? 7   TYR A CD2 1 
ATOM   57    C CE1 . TYR A 1 7   ? 23.306  11.322  -34.345 1.00 38.37  ? 7   TYR A CE1 1 
ATOM   58    C CE2 . TYR A 1 7   ? 21.319  12.212  -35.319 1.00 38.29  ? 7   TYR A CE2 1 
ATOM   59    C CZ  . TYR A 1 7   ? 21.947  11.248  -34.557 1.00 38.75  ? 7   TYR A CZ  1 
ATOM   60    O OH  . TYR A 1 7   ? 21.304  10.183  -34.036 1.00 37.51  ? 7   TYR A OH  1 
ATOM   61    N N   . LEU A 1 8   ? 23.371  13.696  -39.054 1.00 40.38  ? 8   LEU A N   1 
ATOM   62    C CA  . LEU A 1 8   ? 22.593  12.815  -39.910 1.00 42.07  ? 8   LEU A CA  1 
ATOM   63    C C   . LEU A 1 8   ? 23.530  12.104  -40.878 1.00 41.15  ? 8   LEU A C   1 
ATOM   64    O O   . LEU A 1 8   ? 23.471  10.884  -41.024 1.00 38.44  ? 8   LEU A O   1 
ATOM   65    C CB  . LEU A 1 8   ? 21.480  13.574  -40.632 1.00 41.79  ? 8   LEU A CB  1 
ATOM   66    C CG  . LEU A 1 8   ? 20.250  13.907  -39.784 1.00 47.87  ? 8   LEU A CG  1 
ATOM   67    C CD1 . LEU A 1 8   ? 19.283  14.775  -40.526 1.00 47.69  ? 8   LEU A CD1 1 
ATOM   68    C CD2 . LEU A 1 8   ? 19.525  12.644  -39.325 1.00 46.32  ? 8   LEU A CD2 1 
ATOM   69    N N   . GLU A 1 9   ? 24.417  12.861  -41.521 1.00 40.80  ? 9   GLU A N   1 
ATOM   70    C CA  . GLU A 1 9   ? 25.308  12.269  -42.517 1.00 41.23  ? 9   GLU A CA  1 
ATOM   71    C C   . GLU A 1 9   ? 26.115  11.145  -41.891 1.00 37.45  ? 9   GLU A C   1 
ATOM   72    O O   . GLU A 1 9   ? 26.323  10.122  -42.527 1.00 39.85  ? 9   GLU A O   1 
ATOM   73    C CB  . GLU A 1 9   ? 26.252  13.307  -43.132 1.00 50.84  ? 9   GLU A CB  1 
ATOM   74    C CG  . GLU A 1 9   ? 26.935  12.872  -44.430 1.00 61.06  ? 9   GLU A CG  1 
ATOM   75    C CD  . GLU A 1 9   ? 25.999  12.412  -45.536 1.00 67.12  ? 9   GLU A CD  1 
ATOM   76    O OE1 . GLU A 1 9   ? 24.940  13.052  -45.750 1.00 66.40  ? 9   GLU A OE1 1 
ATOM   77    O OE2 . GLU A 1 9   ? 26.329  11.389  -46.168 1.00 64.28  ? 9   GLU A OE2 1 
ATOM   78    N N   . SER A 1 10  ? 26.543  11.311  -40.630 1.00 39.36  ? 10  SER A N   1 
ATOM   79    C CA  . SER A 1 10  ? 27.394  10.313  -39.990 1.00 40.42  ? 10  SER A CA  1 
ATOM   80    C C   . SER A 1 10  ? 26.678  8.972   -39.799 1.00 38.73  ? 10  SER A C   1 
ATOM   81    O O   . SER A 1 10  ? 27.362  7.953   -39.633 1.00 37.23  ? 10  SER A O   1 
ATOM   82    C CB  . SER A 1 10  ? 27.967  10.805  -38.675 1.00 45.61  ? 10  SER A CB  1 
ATOM   83    O OG  . SER A 1 10  ? 26.999  10.911  -37.633 1.00 39.75  ? 10  SER A OG  1 
ATOM   84    N N   . LEU A 1 11  ? 25.330  8.973   -39.841 1.00 39.05  ? 11  LEU A N   1 
ATOM   85    C CA  . LEU A 1 11  ? 24.518  7.765   -39.697 1.00 37.22  ? 11  LEU A CA  1 
ATOM   86    C C   . LEU A 1 11  ? 24.413  6.971   -40.996 1.00 37.93  ? 11  LEU A C   1 
ATOM   87    O O   . LEU A 1 11  ? 24.039  5.798   -40.980 1.00 40.83  ? 11  LEU A O   1 
ATOM   88    C CB  . LEU A 1 11  ? 23.124  8.119   -39.181 1.00 40.48  ? 11  LEU A CB  1 
ATOM   89    C CG  . LEU A 1 11  ? 23.071  8.849   -37.837 1.00 37.19  ? 11  LEU A CG  1 
ATOM   90    C CD1 . LEU A 1 11  ? 21.619  9.016   -37.421 1.00 36.56  ? 11  LEU A CD1 1 
ATOM   91    C CD2 . LEU A 1 11  ? 23.869  8.133   -36.767 1.00 39.18  ? 11  LEU A CD2 1 
ATOM   92    N N   . ARG A 1 12  ? 24.779  7.594   -42.115 1.00 41.39  ? 12  ARG A N   1 
ATOM   93    C CA  . ARG A 1 12  ? 24.754  6.935   -43.403 1.00 39.75  ? 12  ARG A CA  1 
ATOM   94    C C   . ARG A 1 12  ? 26.111  6.316   -43.683 1.00 42.32  ? 12  ARG A C   1 
ATOM   95    O O   . ARG A 1 12  ? 26.822  6.798   -44.533 1.00 49.86  ? 12  ARG A O   1 
ATOM   96    C CB  . ARG A 1 12  ? 24.379  8.006   -44.426 1.00 41.85  ? 12  ARG A CB  1 
ATOM   97    C CG  . ARG A 1 12  ? 22.879  8.213   -44.414 1.00 48.40  ? 12  ARG A CG  1 
ATOM   98    C CD  . ARG A 1 12  ? 22.356  9.127   -45.488 1.00 50.24  ? 12  ARG A CD  1 
ATOM   99    N NE  . ARG A 1 12  ? 22.431  10.477  -44.933 1.00 60.31  ? 12  ARG A NE  1 
ATOM   100   C CZ  . ARG A 1 12  ? 21.934  11.546  -45.533 1.00 83.17  ? 12  ARG A CZ  1 
ATOM   101   N NH1 . ARG A 1 12  ? 21.288  11.396  -46.684 1.00 89.48  ? 12  ARG A NH1 1 
ATOM   102   N NH2 . ARG A 1 12  ? 22.091  12.748  -44.985 1.00 76.31  ? 12  ARG A NH2 1 
ATOM   103   N N   . ASP A 1 13  ? 26.430  5.207   -43.026 1.00 42.35  ? 13  ASP A N   1 
ATOM   104   C CA  . ASP A 1 13  ? 27.787  4.719   -42.971 1.00 36.50  ? 13  ASP A CA  1 
ATOM   105   C C   . ASP A 1 13  ? 27.853  3.214   -43.174 1.00 37.04  ? 13  ASP A C   1 
ATOM   106   O O   . ASP A 1 13  ? 28.855  2.597   -42.766 1.00 41.00  ? 13  ASP A O   1 
ATOM   107   C CB  . ASP A 1 13  ? 28.410  5.028   -41.623 1.00 42.34  ? 13  ASP A CB  1 
ATOM   108   C CG  . ASP A 1 13  ? 27.650  4.536   -40.390 1.00 41.09  ? 13  ASP A CG  1 
ATOM   109   O OD1 . ASP A 1 13  ? 26.548  3.982   -40.568 1.00 43.02  ? 13  ASP A OD1 1 
ATOM   110   O OD2 . ASP A 1 13  ? 28.181  4.692   -39.259 1.00 41.67  ? 13  ASP A OD2 1 
ATOM   111   N N   . GLY A 1 14  ? 26.801  2.637   -43.767 1.00 31.35  ? 14  GLY A N   1 
ATOM   112   C CA  . GLY A 1 14  ? 26.772  1.204   -44.067 1.00 31.47  ? 14  GLY A CA  1 
ATOM   113   C C   . GLY A 1 14  ? 26.507  0.299   -42.861 1.00 35.61  ? 14  GLY A C   1 
ATOM   114   O O   . GLY A 1 14  ? 26.630  -0.927  -42.957 1.00 36.92  ? 14  GLY A O   1 
ATOM   115   N N   . ARG A 1 15  ? 26.141  0.890   -41.712 1.00 39.07  ? 15  ARG A N   1 
ATOM   116   C CA  . ARG A 1 15  ? 25.729  0.125   -40.539 1.00 35.55  ? 15  ARG A CA  1 
ATOM   117   C C   . ARG A 1 15  ? 24.645  -0.869  -40.891 1.00 30.68  ? 15  ARG A C   1 
ATOM   118   O O   . ARG A 1 15  ? 23.783  -0.552  -41.690 1.00 39.30  ? 15  ARG A O   1 
ATOM   119   C CB  . ARG A 1 15  ? 25.074  1.020   -39.479 1.00 34.73  ? 15  ARG A CB  1 
ATOM   120   C CG  . ARG A 1 15  ? 23.901  1.877   -39.923 1.00 36.01  ? 15  ARG A CG  1 
ATOM   121   C CD  . ARG A 1 15  ? 23.550  2.888   -38.825 1.00 37.34  ? 15  ARG A CD  1 
ATOM   122   N NE  . ARG A 1 15  ? 24.696  3.770   -38.585 1.00 37.89  ? 15  ARG A NE  1 
ATOM   123   C CZ  . ARG A 1 15  ? 24.978  4.386   -37.465 1.00 39.07  ? 15  ARG A CZ  1 
ATOM   124   N NH1 . ARG A 1 15  ? 24.112  4.453   -36.466 1.00 39.12  ? 15  ARG A NH1 1 
ATOM   125   N NH2 . ARG A 1 15  ? 26.172  4.900   -37.330 1.00 38.88  ? 15  ARG A NH2 1 
ATOM   126   N N   . GLN A 1 16  ? 24.697  -2.033  -40.256 1.00 30.84  ? 16  GLN A N   1 
ATOM   127   C CA  . GLN A 1 16  ? 23.737  -3.091  -40.426 1.00 32.34  ? 16  GLN A CA  1 
ATOM   128   C C   . GLN A 1 16  ? 22.713  -3.034  -39.294 1.00 34.81  ? 16  GLN A C   1 
ATOM   129   O O   . GLN A 1 16  ? 23.003  -3.419  -38.168 1.00 38.22  ? 16  GLN A O   1 
ATOM   130   C CB  . GLN A 1 16  ? 24.467  -4.424  -40.441 1.00 38.52  ? 16  GLN A CB  1 
ATOM   131   C CG  . GLN A 1 16  ? 25.330  -4.641  -41.673 1.00 50.27  ? 16  GLN A CG  1 
ATOM   132   C CD  . GLN A 1 16  ? 24.523  -4.756  -42.951 1.00 58.40  ? 16  GLN A CD  1 
ATOM   133   O OE1 . GLN A 1 16  ? 23.673  -5.638  -43.108 1.00 55.33  ? 16  GLN A OE1 1 
ATOM   134   N NE2 . GLN A 1 16  ? 24.784  -3.848  -43.879 1.00 64.18  ? 16  GLN A NE2 1 
ATOM   135   N N   . VAL A 1 17  ? 21.483  -2.619  -39.611 1.00 33.54  ? 17  VAL A N   1 
ATOM   136   C CA  . VAL A 1 17  ? 20.504  -2.292  -38.596 1.00 32.30  ? 17  VAL A CA  1 
ATOM   137   C C   . VAL A 1 17  ? 19.197  -2.982  -38.904 1.00 33.39  ? 17  VAL A C   1 
ATOM   138   O O   . VAL A 1 17  ? 18.635  -2.781  -39.988 1.00 33.63  ? 17  VAL A O   1 
ATOM   139   C CB  . VAL A 1 17  ? 20.259  -0.798  -38.491 1.00 33.55  ? 17  VAL A CB  1 
ATOM   140   C CG1 . VAL A 1 17  ? 19.060  -0.520  -37.602 1.00 32.87  ? 17  VAL A CG1 1 
ATOM   141   C CG2 . VAL A 1 17  ? 21.499  -0.116  -37.951 1.00 36.05  ? 17  VAL A CG2 1 
ATOM   142   N N   . TYR A 1 18  ? 18.766  -3.795  -37.929 1.00 34.44  ? 18  TYR A N   1 
ATOM   143   C CA  . TYR A 1 18  ? 17.514  -4.518  -37.998 1.00 39.06  ? 18  TYR A CA  1 
ATOM   144   C C   . TYR A 1 18  ? 16.524  -3.905  -37.002 1.00 40.15  ? 18  TYR A C   1 
ATOM   145   O O   . TYR A 1 18  ? 16.841  -3.724  -35.832 1.00 38.72  ? 18  TYR A O   1 
ATOM   146   C CB  . TYR A 1 18  ? 17.796  -5.994  -37.749 1.00 36.37  ? 18  TYR A CB  1 
ATOM   147   C CG  . TYR A 1 18  ? 18.637  -6.719  -38.792 1.00 38.52  ? 18  TYR A CG  1 
ATOM   148   C CD1 . TYR A 1 18  ? 20.024  -6.718  -38.735 1.00 45.70  ? 18  TYR A CD1 1 
ATOM   149   C CD2 . TYR A 1 18  ? 18.044  -7.488  -39.786 1.00 36.72  ? 18  TYR A CD2 1 
ATOM   150   C CE1 . TYR A 1 18  ? 20.794  -7.422  -39.650 1.00 38.00  ? 18  TYR A CE1 1 
ATOM   151   C CE2 . TYR A 1 18  ? 18.792  -8.195  -40.704 1.00 35.37  ? 18  TYR A CE2 1 
ATOM   152   C CZ  . TYR A 1 18  ? 20.170  -8.133  -40.648 1.00 40.14  ? 18  TYR A CZ  1 
ATOM   153   O OH  . TYR A 1 18  ? 20.907  -8.831  -41.535 1.00 47.88  ? 18  TYR A OH  1 
ATOM   154   N N   . VAL A 1 19  ? 15.321  -3.613  -37.498 1.00 36.48  ? 19  VAL A N   1 
ATOM   155   C CA  . VAL A 1 19  ? 14.227  -3.058  -36.721 1.00 38.15  ? 19  VAL A CA  1 
ATOM   156   C C   . VAL A 1 19  ? 12.979  -3.893  -36.982 1.00 36.40  ? 19  VAL A C   1 
ATOM   157   O O   . VAL A 1 19  ? 12.443  -3.869  -38.078 1.00 35.38  ? 19  VAL A O   1 
ATOM   158   C CB  . VAL A 1 19  ? 13.943  -1.594  -37.093 1.00 34.25  ? 19  VAL A CB  1 
ATOM   159   C CG1 . VAL A 1 19  ? 12.751  -1.093  -36.322 1.00 34.09  ? 19  VAL A CG1 1 
ATOM   160   C CG2 . VAL A 1 19  ? 15.141  -0.690  -36.837 1.00 33.93  ? 19  VAL A CG2 1 
ATOM   161   N N   . GLY A 1 20  ? 12.555  -4.665  -35.989 1.00 37.63  ? 20  GLY A N   1 
ATOM   162   C CA  . GLY A 1 20  ? 11.432  -5.564  -36.155 1.00 38.50  ? 20  GLY A CA  1 
ATOM   163   C C   . GLY A 1 20  ? 11.768  -6.719  -37.078 1.00 36.18  ? 20  GLY A C   1 
ATOM   164   O O   . GLY A 1 20  ? 10.886  -7.471  -37.474 1.00 39.62  ? 20  GLY A O   1 
ATOM   165   N N   . GLY A 1 21  ? 13.050  -6.873  -37.396 1.00 39.32  ? 21  GLY A N   1 
ATOM   166   C CA  . GLY A 1 21  ? 13.483  -7.909  -38.327 1.00 39.50  ? 21  GLY A CA  1 
ATOM   167   C C   . GLY A 1 21  ? 13.710  -7.395  -39.756 1.00 36.42  ? 21  GLY A C   1 
ATOM   168   O O   . GLY A 1 21  ? 14.183  -8.125  -40.608 1.00 36.64  ? 21  GLY A O   1 
ATOM   169   N N   . GLU A 1 22  ? 13.368  -6.148  -40.040 1.00 33.65  ? 22  GLU A N   1 
ATOM   170   C CA  . GLU A 1 22  ? 13.627  -5.599  -41.353 1.00 37.15  ? 22  GLU A CA  1 
ATOM   171   C C   . GLU A 1 22  ? 14.999  -4.955  -41.363 1.00 38.88  ? 22  GLU A C   1 
ATOM   172   O O   . GLU A 1 22  ? 15.313  -4.199  -40.454 1.00 41.47  ? 22  GLU A O   1 
ATOM   173   C CB  . GLU A 1 22  ? 12.617  -4.486  -41.605 1.00 38.42  ? 22  GLU A CB  1 
ATOM   174   C CG  . GLU A 1 22  ? 12.796  -3.788  -42.949 1.00 39.19  ? 22  GLU A CG  1 
ATOM   175   C CD  . GLU A 1 22  ? 11.804  -2.659  -43.182 1.00 36.42  ? 22  GLU A CD  1 
ATOM   176   O OE1 . GLU A 1 22  ? 10.911  -2.404  -42.355 1.00 40.68  ? 22  GLU A OE1 1 
ATOM   177   O OE2 . GLU A 1 22  ? 11.976  -2.002  -44.203 1.00 37.85  ? 22  GLU A OE2 1 
ATOM   178   N N   . LEU A 1 23  ? 15.793  -5.208  -42.402 1.00 42.60  ? 23  LEU A N   1 
ATOM   179   C CA  . LEU A 1 23  ? 17.084  -4.563  -42.537 1.00 35.62  ? 23  LEU A CA  1 
ATOM   180   C C   . LEU A 1 23  ? 16.887  -3.144  -43.054 1.00 36.36  ? 23  LEU A C   1 
ATOM   181   O O   . LEU A 1 23  ? 16.304  -2.998  -44.093 1.00 44.85  ? 23  LEU A O   1 
ATOM   182   C CB  . LEU A 1 23  ? 17.900  -5.363  -43.530 1.00 41.35  ? 23  LEU A CB  1 
ATOM   183   C CG  . LEU A 1 23  ? 19.283  -4.778  -43.854 1.00 45.06  ? 23  LEU A CG  1 
ATOM   184   C CD1 . LEU A 1 23  ? 20.191  -4.723  -42.658 1.00 44.25  ? 23  LEU A CD1 1 
ATOM   185   C CD2 . LEU A 1 23  ? 19.936  -5.607  -44.959 1.00 51.99  ? 23  LEU A CD2 1 
ATOM   186   N N   . ILE A 1 24  ? 17.356  -2.115  -42.338 1.00 36.11  ? 24  ILE A N   1 
ATOM   187   C CA  . ILE A 1 24  ? 17.097  -0.725  -42.676 1.00 34.78  ? 24  ILE A CA  1 
ATOM   188   C C   . ILE A 1 24  ? 18.255  -0.204  -43.518 1.00 41.95  ? 24  ILE A C   1 
ATOM   189   O O   . ILE A 1 24  ? 19.367  -0.067  -43.021 1.00 47.46  ? 24  ILE A O   1 
ATOM   190   C CB  . ILE A 1 24  ? 16.925  0.141   -41.411 1.00 35.58  ? 24  ILE A CB  1 
ATOM   191   C CG1 . ILE A 1 24  ? 15.670  -0.163  -40.636 1.00 41.83  ? 24  ILE A CG1 1 
ATOM   192   C CG2 . ILE A 1 24  ? 16.905  1.612   -41.785 1.00 37.29  ? 24  ILE A CG2 1 
ATOM   193   C CD1 . ILE A 1 24  ? 15.510  -1.601  -40.247 1.00 49.26  ? 24  ILE A CD1 1 
ATOM   194   N N   . ASP A 1 25  ? 17.964  0.128   -44.771 1.00 44.17  ? 25  ASP A N   1 
ATOM   195   C CA  . ASP A 1 25  ? 18.911  0.684   -45.722 1.00 43.57  ? 25  ASP A CA  1 
ATOM   196   C C   . ASP A 1 25  ? 19.563  1.951   -45.186 1.00 43.34  ? 25  ASP A C   1 
ATOM   197   O O   . ASP A 1 25  ? 20.779  2.102   -45.255 1.00 47.76  ? 25  ASP A O   1 
ATOM   198   C CB  . ASP A 1 25  ? 18.210  0.974   -47.045 1.00 49.93  ? 25  ASP A CB  1 
ATOM   199   C CG  . ASP A 1 25  ? 16.885  1.750   -47.013 1.00 61.81  ? 25  ASP A CG  1 
ATOM   200   O OD1 . ASP A 1 25  ? 16.402  2.122   -45.906 1.00 55.10  ? 25  ASP A OD1 1 
ATOM   201   O OD2 . ASP A 1 25  ? 16.313  1.987   -48.118 1.00 67.27  ? 25  ASP A OD2 1 
ATOM   202   N N   . ASP A 1 26  ? 18.727  2.881   -44.721 1.00 38.56  ? 26  ASP A N   1 
ATOM   203   C CA  . ASP A 1 26  ? 19.159  4.222   -44.363 1.00 38.99  ? 26  ASP A CA  1 
ATOM   204   C C   . ASP A 1 26  ? 18.285  4.700   -43.206 1.00 38.64  ? 26  ASP A C   1 
ATOM   205   O O   . ASP A 1 26  ? 17.078  4.898   -43.339 1.00 38.59  ? 26  ASP A O   1 
ATOM   206   C CB  . ASP A 1 26  ? 19.087  5.195   -45.528 1.00 41.00  ? 26  ASP A CB  1 
ATOM   207   C CG  . ASP A 1 26  ? 19.565  6.618   -45.252 1.00 44.68  ? 26  ASP A CG  1 
ATOM   208   O OD1 . ASP A 1 26  ? 19.440  7.084   -44.111 1.00 43.75  ? 26  ASP A OD1 1 
ATOM   209   O OD2 . ASP A 1 26  ? 19.993  7.291   -46.197 1.00 54.21  ? 26  ASP A OD2 1 
ATOM   210   N N   . VAL A 1 27  ? 18.931  4.860   -42.059 1.00 34.54  ? 27  VAL A N   1 
ATOM   211   C CA  . VAL A 1 27  ? 18.259  5.157   -40.820 1.00 37.62  ? 27  VAL A CA  1 
ATOM   212   C C   . VAL A 1 27  ? 17.699  6.571   -40.832 1.00 37.84  ? 27  VAL A C   1 
ATOM   213   O O   . VAL A 1 27  ? 16.720  6.831   -40.145 1.00 41.19  ? 27  VAL A O   1 
ATOM   214   C CB  . VAL A 1 27  ? 19.345  4.933   -39.764 1.00 38.98  ? 27  VAL A CB  1 
ATOM   215   C CG1 . VAL A 1 27  ? 19.261  5.925   -38.640 1.00 45.07  ? 27  VAL A CG1 1 
ATOM   216   C CG2 . VAL A 1 27  ? 19.289  3.511   -39.260 1.00 39.22  ? 27  VAL A CG2 1 
ATOM   217   N N   . THR A 1 28  ? 18.285  7.467   -41.634 1.00 36.56  ? 28  THR A N   1 
ATOM   218   C CA  . THR A 1 28  ? 17.825  8.854   -41.691 1.00 38.64  ? 28  THR A CA  1 
ATOM   219   C C   . THR A 1 28  ? 16.604  9.021   -42.590 1.00 36.10  ? 28  THR A C   1 
ATOM   220   O O   . THR A 1 28  ? 16.018  10.091  -42.549 1.00 36.83  ? 28  THR A O   1 
ATOM   221   C CB  . THR A 1 28  ? 18.900  9.819   -42.204 1.00 37.46  ? 28  THR A CB  1 
ATOM   222   O OG1 . THR A 1 28  ? 19.129  9.479   -43.567 1.00 37.65  ? 28  THR A OG1 1 
ATOM   223   C CG2 . THR A 1 28  ? 20.224  9.709   -41.474 1.00 39.94  ? 28  THR A CG2 1 
ATOM   224   N N   . THR A 1 29  ? 16.243  8.029   -43.426 1.00 39.90  ? 29  THR A N   1 
ATOM   225   C CA  . THR A 1 29  ? 15.095  8.194   -44.322 1.00 39.66  ? 29  THR A CA  1 
ATOM   226   C C   . THR A 1 29  ? 13.991  7.173   -44.068 1.00 37.50  ? 29  THR A C   1 
ATOM   227   O O   . THR A 1 29  ? 12.862  7.415   -44.468 1.00 40.98  ? 29  THR A O   1 
ATOM   228   C CB  . THR A 1 29  ? 15.509  8.103   -45.793 1.00 42.74  ? 29  THR A CB  1 
ATOM   229   O OG1 . THR A 1 29  ? 16.069  6.812   -46.042 1.00 39.17  ? 29  THR A OG1 1 
ATOM   230   C CG2 . THR A 1 29  ? 16.433  9.240   -46.179 1.00 41.35  ? 29  THR A CG2 1 
ATOM   231   N N   . HIS A 1 30  ? 14.313  6.003   -43.500 1.00 36.02  ? 30  HIS A N   1 
ATOM   232   C CA  . HIS A 1 30  ? 13.306  4.975   -43.298 1.00 35.55  ? 30  HIS A CA  1 
ATOM   233   C C   . HIS A 1 30  ? 12.243  5.485   -42.320 1.00 36.43  ? 30  HIS A C   1 
ATOM   234   O O   . HIS A 1 30  ? 12.514  6.124   -41.313 1.00 40.04  ? 30  HIS A O   1 
ATOM   235   C CB  . HIS A 1 30  ? 13.943  3.653   -42.872 1.00 34.14  ? 30  HIS A CB  1 
ATOM   236   C CG  . HIS A 1 30  ? 13.065  2.458   -42.996 1.00 34.32  ? 30  HIS A CG  1 
ATOM   237   N ND1 . HIS A 1 30  ? 11.911  2.288   -42.255 1.00 35.28  ? 30  HIS A ND1 1 
ATOM   238   C CD2 . HIS A 1 30  ? 13.193  1.349   -43.749 1.00 34.92  ? 30  HIS A CD2 1 
ATOM   239   C CE1 . HIS A 1 30  ? 11.361  1.097   -42.553 1.00 32.77  ? 30  HIS A CE1 1 
ATOM   240   N NE2 . HIS A 1 30  ? 12.115  0.501   -43.479 1.00 32.23  ? 30  HIS A NE2 1 
ATOM   241   N N   . PRO A 1 31  ? 10.958  5.330   -42.644 1.00 36.55  ? 31  PRO A N   1 
ATOM   242   C CA  . PRO A 1 31  ? 9.906   5.757   -41.739 1.00 35.03  ? 31  PRO A CA  1 
ATOM   243   C C   . PRO A 1 31  ? 10.051  5.236   -40.319 1.00 34.60  ? 31  PRO A C   1 
ATOM   244   O O   . PRO A 1 31  ? 9.564   5.869   -39.399 1.00 37.19  ? 31  PRO A O   1 
ATOM   245   C CB  . PRO A 1 31  ? 8.621   5.221   -42.388 1.00 37.76  ? 31  PRO A CB  1 
ATOM   246   C CG  . PRO A 1 31  ? 8.965   4.990   -43.820 1.00 40.11  ? 31  PRO A CG  1 
ATOM   247   C CD  . PRO A 1 31  ? 10.468  4.840   -43.928 1.00 38.92  ? 31  PRO A CD  1 
ATOM   248   N N   . LYS A 1 32  ? 10.620  4.042   -40.143 1.00 35.12  ? 32  LYS A N   1 
ATOM   249   C CA  . LYS A 1 32  ? 10.677  3.467   -38.814 1.00 34.93  ? 32  LYS A CA  1 
ATOM   250   C C   . LYS A 1 32  ? 11.645  4.249   -37.926 1.00 34.43  ? 32  LYS A C   1 
ATOM   251   O O   . LYS A 1 32  ? 11.477  4.214   -36.707 1.00 31.32  ? 32  LYS A O   1 
ATOM   252   C CB  . LYS A 1 32  ? 11.063  1.984   -38.774 1.00 32.87  ? 32  LYS A CB  1 
ATOM   253   C CG  . LYS A 1 32  ? 9.994   1.029   -39.261 1.00 32.70  ? 32  LYS A CG  1 
ATOM   254   C CD  . LYS A 1 32  ? 10.487  -0.405  -39.464 1.00 33.40  ? 32  LYS A CD  1 
ATOM   255   C CE  . LYS A 1 32  ? 9.383   -1.356  -39.758 1.00 33.45  ? 32  LYS A CE  1 
ATOM   256   N NZ  . LYS A 1 32  ? 9.811   -2.740  -39.600 1.00 37.38  ? 32  LYS A NZ  1 
ATOM   257   N N   . THR A 1 33  ? 12.665  4.892   -38.513 1.00 31.90  ? 33  THR A N   1 
ATOM   258   C CA  . THR A 1 33  ? 13.761  5.418   -37.700 1.00 33.76  ? 33  THR A CA  1 
ATOM   259   C C   . THR A 1 33  ? 13.973  6.922   -37.842 1.00 34.23  ? 33  THR A C   1 
ATOM   260   O O   . THR A 1 33  ? 14.721  7.488   -37.069 1.00 35.08  ? 33  THR A O   1 
ATOM   261   C CB  . THR A 1 33  ? 15.053  4.697   -38.039 1.00 37.08  ? 33  THR A CB  1 
ATOM   262   O OG1 . THR A 1 33  ? 15.196  4.852   -39.448 1.00 36.66  ? 33  THR A OG1 1 
ATOM   263   C CG2 . THR A 1 33  ? 15.019  3.249   -37.596 1.00 37.34  ? 33  THR A CG2 1 
ATOM   264   N N   . SER A 1 34  ? 13.333  7.568   -38.812 1.00 36.44  ? 34  SER A N   1 
ATOM   265   C CA  . SER A 1 34  ? 13.775  8.863   -39.283 1.00 35.48  ? 34  SER A CA  1 
ATOM   266   C C   . SER A 1 34  ? 13.352  9.972   -38.340 1.00 33.25  ? 34  SER A C   1 
ATOM   267   O O   . SER A 1 34  ? 14.034  10.957  -38.275 1.00 39.12  ? 34  SER A O   1 
ATOM   268   C CB  . SER A 1 34  ? 13.272  9.149   -40.691 1.00 36.18  ? 34  SER A CB  1 
ATOM   269   O OG  . SER A 1 34  ? 11.855  9.249   -40.727 1.00 39.93  ? 34  SER A OG  1 
ATOM   270   N N   . GLY A 1 35  ? 12.163  9.889   -37.734 1.00 36.44  ? 35  GLY A N   1 
ATOM   271   C CA  . GLY A 1 35  ? 11.724  10.900  -36.777 1.00 30.97  ? 35  GLY A CA  1 
ATOM   272   C C   . GLY A 1 35  ? 12.705  11.043  -35.607 1.00 32.96  ? 35  GLY A C   1 
ATOM   273   O O   . GLY A 1 35  ? 13.091  12.149  -35.239 1.00 37.65  ? 35  GLY A O   1 
ATOM   274   N N   . TYR A 1 36  ? 13.138  9.922   -35.023 1.00 28.92  ? 36  TYR A N   1 
ATOM   275   C CA  . TYR A 1 36  ? 14.066  10.008  -33.916 1.00 32.80  ? 36  TYR A CA  1 
ATOM   276   C C   . TYR A 1 36  ? 15.410  10.567  -34.392 1.00 34.07  ? 36  TYR A C   1 
ATOM   277   O O   . TYR A 1 36  ? 15.983  11.428  -33.740 1.00 37.42  ? 36  TYR A O   1 
ATOM   278   C CB  . TYR A 1 36  ? 14.190  8.671   -33.193 1.00 33.34  ? 36  TYR A CB  1 
ATOM   279   C CG  . TYR A 1 36  ? 15.091  8.789   -31.973 1.00 31.43  ? 36  TYR A CG  1 
ATOM   280   C CD1 . TYR A 1 36  ? 14.637  9.334   -30.788 1.00 31.77  ? 36  TYR A CD1 1 
ATOM   281   C CD2 . TYR A 1 36  ? 16.399  8.358   -32.019 1.00 33.46  ? 36  TYR A CD2 1 
ATOM   282   C CE1 . TYR A 1 36  ? 15.462  9.449   -29.689 1.00 35.12  ? 36  TYR A CE1 1 
ATOM   283   C CE2 . TYR A 1 36  ? 17.236  8.455   -30.925 1.00 36.64  ? 36  TYR A CE2 1 
ATOM   284   C CZ  . TYR A 1 36  ? 16.765  9.002   -29.750 1.00 35.98  ? 36  TYR A CZ  1 
ATOM   285   O OH  . TYR A 1 36  ? 17.597  9.109   -28.676 1.00 36.16  ? 36  TYR A OH  1 
ATOM   286   N N   . ALA A 1 37  ? 15.878  10.128  -35.551 1.00 35.03  ? 37  ALA A N   1 
ATOM   287   C CA  . ALA A 1 37  ? 17.097  10.661  -36.134 1.00 38.47  ? 37  ALA A CA  1 
ATOM   288   C C   . ALA A 1 37  ? 17.017  12.182  -36.227 1.00 42.05  ? 37  ALA A C   1 
ATOM   289   O O   . ALA A 1 37  ? 17.955  12.861  -35.810 1.00 45.38  ? 37  ALA A O   1 
ATOM   290   C CB  . ALA A 1 37  ? 17.339  10.044  -37.474 1.00 36.37  ? 37  ALA A CB  1 
ATOM   291   N N   . LYS A 1 38  ? 15.891  12.688  -36.742 1.00 40.50  ? 38  LYS A N   1 
ATOM   292   C CA  . LYS A 1 38  ? 15.661  14.113  -36.876 1.00 44.57  ? 38  LYS A CA  1 
ATOM   293   C C   . LYS A 1 38  ? 15.622  14.778  -35.499 1.00 44.62  ? 38  LYS A C   1 
ATOM   294   O O   . LYS A 1 38  ? 16.051  15.915  -35.361 1.00 39.61  ? 38  LYS A O   1 
ATOM   295   C CB  . LYS A 1 38  ? 14.390  14.440  -37.671 1.00 51.14  ? 38  LYS A CB  1 
ATOM   296   C CG  . LYS A 1 38  ? 14.578  15.113  -39.037 1.00 69.83  ? 38  LYS A CG  1 
ATOM   297   C CD  . LYS A 1 38  ? 14.752  14.179  -40.238 1.00 90.36  ? 38  LYS A CD  1 
ATOM   298   C CE  . LYS A 1 38  ? 15.406  14.834  -41.440 1.00 98.10  ? 38  LYS A CE  1 
ATOM   299   N NZ  . LYS A 1 38  ? 15.670  13.898  -42.544 1.00 104.63 ? 38  LYS A NZ  1 
ATOM   300   N N   . ALA A 1 39  ? 15.130  14.085  -34.467 1.00 40.63  ? 39  ALA A N   1 
ATOM   301   C CA  . ALA A 1 39  ? 15.024  14.734  -33.168 1.00 40.76  ? 39  ALA A CA  1 
ATOM   302   C C   . ALA A 1 39  ? 16.411  14.922  -32.553 1.00 38.42  ? 39  ALA A C   1 
ATOM   303   O O   . ALA A 1 39  ? 16.694  15.951  -31.950 1.00 42.77  ? 39  ALA A O   1 
ATOM   304   C CB  . ALA A 1 39  ? 14.093  13.997  -32.231 1.00 37.08  ? 39  ALA A CB  1 
ATOM   305   N N   . ILE A 1 40  ? 17.309  13.964  -32.758 1.00 43.03  ? 40  ILE A N   1 
ATOM   306   C CA  . ILE A 1 40  ? 18.669  14.114  -32.264 1.00 38.25  ? 40  ILE A CA  1 
ATOM   307   C C   . ILE A 1 40  ? 19.405  15.151  -33.118 1.00 37.93  ? 40  ILE A C   1 
ATOM   308   O O   . ILE A 1 40  ? 20.251  15.864  -32.621 1.00 38.45  ? 40  ILE A O   1 
ATOM   309   C CB  . ILE A 1 40  ? 19.375  12.749  -32.207 1.00 39.88  ? 40  ILE A CB  1 
ATOM   310   C CG1 . ILE A 1 40  ? 18.581  11.735  -31.402 1.00 39.67  ? 40  ILE A CG1 1 
ATOM   311   C CG2 . ILE A 1 40  ? 20.787  12.864  -31.642 1.00 40.87  ? 40  ILE A CG2 1 
ATOM   312   C CD1 . ILE A 1 40  ? 18.216  12.232  -30.026 1.00 39.28  ? 40  ILE A CD1 1 
ATOM   313   N N   . ALA A 1 41  ? 19.087  15.256  -34.404 1.00 38.59  ? 41  ALA A N   1 
ATOM   314   C CA  . ALA A 1 41  ? 19.734  16.225  -35.264 1.00 37.47  ? 41  ALA A CA  1 
ATOM   315   C C   . ALA A 1 41  ? 19.429  17.653  -34.799 1.00 40.40  ? 41  ALA A C   1 
ATOM   316   O O   . ALA A 1 41  ? 20.301  18.504  -34.739 1.00 43.09  ? 41  ALA A O   1 
ATOM   317   C CB  . ALA A 1 41  ? 19.282  15.997  -36.671 1.00 36.03  ? 41  ALA A CB  1 
ATOM   318   N N   . GLU A 1 42  ? 18.174  17.904  -34.469 1.00 42.14  ? 42  GLU A N   1 
ATOM   319   C CA  . GLU A 1 42  ? 17.753  19.139  -33.838 1.00 45.31  ? 42  GLU A CA  1 
ATOM   320   C C   . GLU A 1 42  ? 18.483  19.352  -32.509 1.00 45.15  ? 42  GLU A C   1 
ATOM   321   O O   . GLU A 1 42  ? 18.849  20.474  -32.189 1.00 49.75  ? 42  GLU A O   1 
ATOM   322   C CB  . GLU A 1 42  ? 16.241  18.988  -33.676 1.00 47.71  ? 42  GLU A CB  1 
ATOM   323   C CG  . GLU A 1 42  ? 15.488  20.255  -33.272 1.00 61.37  ? 42  GLU A CG  1 
ATOM   324   C CD  . GLU A 1 42  ? 14.005  19.990  -32.974 1.00 73.11  ? 42  GLU A CD  1 
ATOM   325   O OE1 . GLU A 1 42  ? 13.420  20.840  -32.245 1.00 57.08  ? 42  GLU A OE1 1 
ATOM   326   O OE2 . GLU A 1 42  ? 13.444  18.947  -33.465 1.00 67.34  ? 42  GLU A OE2 1 
ATOM   327   N N   . TYR A 1 43  ? 18.658  18.283  -31.725 1.00 41.42  ? 43  TYR A N   1 
ATOM   328   C CA  . TYR A 1 43  ? 19.393  18.340  -30.474 1.00 42.70  ? 43  TYR A CA  1 
ATOM   329   C C   . TYR A 1 43  ? 20.755  18.980  -30.726 1.00 41.47  ? 43  TYR A C   1 
ATOM   330   O O   . TYR A 1 43  ? 21.150  19.894  -30.004 1.00 45.76  ? 43  TYR A O   1 
ATOM   331   C CB  . TYR A 1 43  ? 19.488  16.941  -29.840 1.00 36.26  ? 43  TYR A CB  1 
ATOM   332   C CG  . TYR A 1 43  ? 20.494  16.733  -28.716 1.00 30.83  ? 43  TYR A CG  1 
ATOM   333   C CD1 . TYR A 1 43  ? 21.825  16.461  -28.983 1.00 35.65  ? 43  TYR A CD1 1 
ATOM   334   C CD2 . TYR A 1 43  ? 20.116  16.751  -27.388 1.00 34.07  ? 43  TYR A CD2 1 
ATOM   335   C CE1 . TYR A 1 43  ? 22.752  16.246  -27.972 1.00 33.56  ? 43  TYR A CE1 1 
ATOM   336   C CE2 . TYR A 1 43  ? 21.021  16.521  -26.359 1.00 33.51  ? 43  TYR A CE2 1 
ATOM   337   C CZ  . TYR A 1 43  ? 22.356  16.288  -26.649 1.00 34.35  ? 43  TYR A CZ  1 
ATOM   338   O OH  . TYR A 1 43  ? 23.285  16.093  -25.657 1.00 32.77  ? 43  TYR A OH  1 
ATOM   339   N N   . TYR A 1 44  ? 21.457  18.512  -31.759 1.00 39.67  ? 44  TYR A N   1 
ATOM   340   C CA  . TYR A 1 44  ? 22.777  19.046  -32.083 1.00 39.90  ? 44  TYR A CA  1 
ATOM   341   C C   . TYR A 1 44  ? 22.668  20.510  -32.522 1.00 40.22  ? 44  TYR A C   1 
ATOM   342   O O   . TYR A 1 44  ? 23.506  21.313  -32.122 1.00 51.13  ? 44  TYR A O   1 
ATOM   343   C CB  . TYR A 1 44  ? 23.530  18.229  -33.129 1.00 34.94  ? 44  TYR A CB  1 
ATOM   344   C CG  . TYR A 1 44  ? 24.193  16.971  -32.592 1.00 35.64  ? 44  TYR A CG  1 
ATOM   345   C CD1 . TYR A 1 44  ? 25.498  17.014  -32.133 1.00 38.74  ? 44  TYR A CD1 1 
ATOM   346   C CD2 . TYR A 1 44  ? 23.543  15.742  -32.578 1.00 35.51  ? 44  TYR A CD2 1 
ATOM   347   C CE1 . TYR A 1 44  ? 26.140  15.887  -31.652 1.00 39.81  ? 44  TYR A CE1 1 
ATOM   348   C CE2 . TYR A 1 44  ? 24.168  14.600  -32.090 1.00 34.40  ? 44  TYR A CE2 1 
ATOM   349   C CZ  . TYR A 1 44  ? 25.467  14.681  -31.621 1.00 36.32  ? 44  TYR A CZ  1 
ATOM   350   O OH  . TYR A 1 44  ? 26.134  13.629  -31.104 1.00 37.91  ? 44  TYR A OH  1 
ATOM   351   N N   . ASP A 1 45  ? 21.622  20.876  -33.273 1.00 38.55  ? 45  ASP A N   1 
ATOM   352   C CA  . ASP A 1 45  ? 21.509  22.235  -33.802 1.00 41.87  ? 45  ASP A CA  1 
ATOM   353   C C   . ASP A 1 45  ? 21.240  23.236  -32.684 1.00 41.76  ? 45  ASP A C   1 
ATOM   354   O O   . ASP A 1 45  ? 21.803  24.315  -32.679 1.00 44.43  ? 45  ASP A O   1 
ATOM   355   C CB  . ASP A 1 45  ? 20.471  22.345  -34.900 1.00 38.57  ? 45  ASP A CB  1 
ATOM   356   C CG  . ASP A 1 45  ? 20.897  21.803  -36.248 1.00 37.82  ? 45  ASP A CG  1 
ATOM   357   O OD1 . ASP A 1 45  ? 22.101  21.781  -36.534 1.00 47.49  ? 45  ASP A OD1 1 
ATOM   358   O OD2 . ASP A 1 45  ? 20.022  21.377  -36.988 1.00 47.00  ? 45  ASP A OD2 1 
ATOM   359   N N   . LEU A 1 46  ? 20.439  22.847  -31.694 1.00 41.81  ? 46  LEU A N   1 
ATOM   360   C CA  . LEU A 1 46  ? 20.200  23.715  -30.560 1.00 43.21  ? 46  LEU A CA  1 
ATOM   361   C C   . LEU A 1 46  ? 21.501  24.039  -29.817 1.00 45.20  ? 46  LEU A C   1 
ATOM   362   O O   . LEU A 1 46  ? 21.698  25.152  -29.353 1.00 42.65  ? 46  LEU A O   1 
ATOM   363   C CB  . LEU A 1 46  ? 19.183  23.035  -29.655 1.00 43.55  ? 46  LEU A CB  1 
ATOM   364   C CG  . LEU A 1 46  ? 17.747  23.034  -30.184 1.00 46.97  ? 46  LEU A CG  1 
ATOM   365   C CD1 . LEU A 1 46  ? 16.857  22.127  -29.366 1.00 48.18  ? 46  LEU A CD1 1 
ATOM   366   C CD2 . LEU A 1 46  ? 17.175  24.450  -30.199 1.00 47.76  ? 46  LEU A CD2 1 
ATOM   367   N N   . HIS A 1 47  ? 22.418  23.090  -29.680 1.00 48.66  ? 47  HIS A N   1 
ATOM   368   C CA  . HIS A 1 47  ? 23.651  23.420  -28.977 1.00 48.68  ? 47  HIS A CA  1 
ATOM   369   C C   . HIS A 1 47  ? 24.402  24.565  -29.662 1.00 46.77  ? 47  HIS A C   1 
ATOM   370   O O   . HIS A 1 47  ? 25.060  25.352  -28.983 1.00 45.48  ? 47  HIS A O   1 
ATOM   371   C CB  . HIS A 1 47  ? 24.560  22.205  -28.842 1.00 45.84  ? 47  HIS A CB  1 
ATOM   372   C CG  . HIS A 1 47  ? 24.138  21.237  -27.807 1.00 45.37  ? 47  HIS A CG  1 
ATOM   373   N ND1 . HIS A 1 47  ? 23.131  20.325  -28.005 1.00 45.76  ? 47  HIS A ND1 1 
ATOM   374   C CD2 . HIS A 1 47  ? 24.614  21.015  -26.591 1.00 43.88  ? 47  HIS A CD2 1 
ATOM   375   C CE1 . HIS A 1 47  ? 23.018  19.575  -26.920 1.00 44.10  ? 47  HIS A CE1 1 
ATOM   376   N NE2 . HIS A 1 47  ? 23.917  19.970  -26.055 1.00 43.15  ? 47  HIS A NE2 1 
ATOM   377   N N   . LEU A 1 48  ? 24.267  24.659  -30.991 1.00 46.54  ? 48  LEU A N   1 
ATOM   378   C CA  . LEU A 1 48  ? 24.961  25.659  -31.787 1.00 49.11  ? 48  LEU A CA  1 
ATOM   379   C C   . LEU A 1 48  ? 24.209  26.985  -31.770 1.00 52.26  ? 48  LEU A C   1 
ATOM   380   O O   . LEU A 1 48  ? 24.747  28.002  -32.182 1.00 53.96  ? 48  LEU A O   1 
ATOM   381   C CB  . LEU A 1 48  ? 25.154  25.133  -33.212 1.00 47.74  ? 48  LEU A CB  1 
ATOM   382   C CG  . LEU A 1 48  ? 26.281  24.103  -33.371 1.00 49.51  ? 48  LEU A CG  1 
ATOM   383   C CD1 . LEU A 1 48  ? 26.257  23.393  -34.708 1.00 49.39  ? 48  LEU A CD1 1 
ATOM   384   C CD2 . LEU A 1 48  ? 27.650  24.733  -33.164 1.00 47.32  ? 48  LEU A CD2 1 
ATOM   385   N N   . ASP A 1 49  ? 22.969  26.978  -31.278 1.00 58.39  ? 49  ASP A N   1 
ATOM   386   C CA  . ASP A 1 49  ? 22.154  28.179  -31.284 1.00 57.52  ? 49  ASP A CA  1 
ATOM   387   C C   . ASP A 1 49  ? 22.612  29.140  -30.196 1.00 57.96  ? 49  ASP A C   1 
ATOM   388   O O   . ASP A 1 49  ? 22.497  28.846  -29.018 1.00 56.26  ? 49  ASP A O   1 
ATOM   389   C CB  . ASP A 1 49  ? 20.690  27.877  -31.032 1.00 56.56  ? 49  ASP A CB  1 
ATOM   390   C CG  . ASP A 1 49  ? 19.734  29.034  -31.275 1.00 63.46  ? 49  ASP A CG  1 
ATOM   391   O OD1 . ASP A 1 49  ? 20.009  30.171  -30.798 1.00 60.91  ? 49  ASP A OD1 1 
ATOM   392   O OD2 . ASP A 1 49  ? 18.711  28.780  -31.935 1.00 69.36  ? 49  ASP A OD2 1 
ATOM   393   N N   . PRO A 1 50  ? 23.065  30.360  -30.550 1.00 74.29  ? 50  PRO A N   1 
ATOM   394   C CA  . PRO A 1 50  ? 23.471  31.359  -29.548 1.00 70.85  ? 50  PRO A CA  1 
ATOM   395   C C   . PRO A 1 50  ? 22.520  31.610  -28.380 1.00 60.00  ? 50  PRO A C   1 
ATOM   396   O O   . PRO A 1 50  ? 22.951  31.897  -27.272 1.00 57.60  ? 50  PRO A O   1 
ATOM   397   C CB  . PRO A 1 50  ? 23.602  32.601  -30.430 1.00 78.63  ? 50  PRO A CB  1 
ATOM   398   C CG  . PRO A 1 50  ? 24.105  32.045  -31.745 1.00 83.05  ? 50  PRO A CG  1 
ATOM   399   C CD  . PRO A 1 50  ? 23.239  30.818  -31.938 1.00 76.32  ? 50  PRO A CD  1 
ATOM   400   N N   . GLU A 1 51  ? 21.218  31.511  -28.629 1.00 60.84  ? 51  GLU A N   1 
ATOM   401   C CA  . GLU A 1 51  ? 20.238  31.781  -27.594 1.00 66.69  ? 51  GLU A CA  1 
ATOM   402   C C   . GLU A 1 51  ? 20.426  30.818  -26.416 1.00 69.21  ? 51  GLU A C   1 
ATOM   403   O O   . GLU A 1 51  ? 20.141  31.167  -25.277 1.00 59.75  ? 51  GLU A O   1 
ATOM   404   C CB  . GLU A 1 51  ? 18.855  31.709  -28.237 1.00 77.36  ? 51  GLU A CB  1 
ATOM   405   C CG  . GLU A 1 51  ? 17.731  32.276  -27.371 1.00 88.74  ? 51  GLU A CG  1 
ATOM   406   C CD  . GLU A 1 51  ? 16.358  32.170  -28.021 1.00 93.53  ? 51  GLU A CD  1 
ATOM   407   O OE1 . GLU A 1 51  ? 16.298  31.991  -29.259 1.00 94.61  ? 51  GLU A OE1 1 
ATOM   408   O OE2 . GLU A 1 51  ? 15.347  32.225  -27.292 1.00 96.80  ? 51  GLU A OE2 1 
ATOM   409   N N   . HIS A 1 52  ? 20.930  29.603  -26.656 1.00 61.72  ? 52  HIS A N   1 
ATOM   410   C CA  . HIS A 1 52  ? 20.995  28.633  -25.577 1.00 55.99  ? 52  HIS A CA  1 
ATOM   411   C C   . HIS A 1 52  ? 22.437  28.351  -25.165 1.00 55.33  ? 52  HIS A C   1 
ATOM   412   O O   . HIS A 1 52  ? 22.683  27.359  -24.478 1.00 55.42  ? 52  HIS A O   1 
ATOM   413   C CB  . HIS A 1 52  ? 20.260  27.349  -25.966 1.00 49.90  ? 52  HIS A CB  1 
ATOM   414   C CG  . HIS A 1 52  ? 18.895  27.556  -26.522 1.00 46.05  ? 52  HIS A CG  1 
ATOM   415   N ND1 . HIS A 1 52  ? 17.833  27.942  -25.725 1.00 49.96  ? 52  HIS A ND1 1 
ATOM   416   C CD2 . HIS A 1 52  ? 18.406  27.417  -27.764 1.00 45.24  ? 52  HIS A CD2 1 
ATOM   417   C CE1 . HIS A 1 52  ? 16.735  28.030  -26.480 1.00 46.68  ? 52  HIS A CE1 1 
ATOM   418   N NE2 . HIS A 1 52  ? 17.055  27.708  -27.723 1.00 44.03  ? 52  HIS A NE2 1 
ATOM   419   N N   . GLN A 1 53  ? 23.368  29.249  -25.519 1.00 53.89  ? 53  GLN A N   1 
ATOM   420   C CA  . GLN A 1 53  ? 24.782  29.075  -25.203 1.00 54.91  ? 53  GLN A CA  1 
ATOM   421   C C   . GLN A 1 53  ? 25.036  28.918  -23.703 1.00 53.88  ? 53  GLN A C   1 
ATOM   422   O O   . GLN A 1 53  ? 25.865  28.115  -23.296 1.00 61.59  ? 53  GLN A O   1 
ATOM   423   C CB  . GLN A 1 53  ? 25.623  30.255  -25.677 1.00 57.83  ? 53  GLN A CB  1 
ATOM   424   C CG  . GLN A 1 53  ? 27.122  29.984  -25.605 1.00 68.93  ? 53  GLN A CG  1 
ATOM   425   C CD  . GLN A 1 53  ? 27.967  31.114  -26.161 1.00 73.15  ? 53  GLN A CD  1 
ATOM   426   O OE1 . GLN A 1 53  ? 28.004  31.355  -27.372 1.00 63.36  ? 53  GLN A OE1 1 
ATOM   427   N NE2 . GLN A 1 53  ? 28.674  31.807  -25.281 1.00 72.78  ? 53  GLN A NE2 1 
ATOM   428   N N   . ASP A 1 54  ? 24.362  29.700  -22.866 1.00 55.59  ? 54  ASP A N   1 
ATOM   429   C CA  . ASP A 1 54  ? 24.692  29.697  -21.451 1.00 55.02  ? 54  ASP A CA  1 
ATOM   430   C C   . ASP A 1 54  ? 24.405  28.337  -20.835 1.00 52.11  ? 54  ASP A C   1 
ATOM   431   O O   . ASP A 1 54  ? 25.217  27.826  -20.076 1.00 53.09  ? 54  ASP A O   1 
ATOM   432   C CB  . ASP A 1 54  ? 23.967  30.788  -20.684 1.00 60.23  ? 54  ASP A CB  1 
ATOM   433   C CG  . ASP A 1 54  ? 24.511  32.197  -20.888 1.00 72.77  ? 54  ASP A CG  1 
ATOM   434   O OD1 . ASP A 1 54  ? 25.168  32.432  -21.926 1.00 84.85  ? 54  ASP A OD1 1 
ATOM   435   O OD2 . ASP A 1 54  ? 24.298  33.042  -19.995 1.00 76.35  ? 54  ASP A OD2 1 
ATOM   436   N N   . VAL A 1 55  ? 23.243  27.758  -21.146 1.00 53.22  ? 55  VAL A N   1 
ATOM   437   C CA  . VAL A 1 55  ? 22.839  26.525  -20.491 1.00 47.46  ? 55  VAL A CA  1 
ATOM   438   C C   . VAL A 1 55  ? 23.387  25.306  -21.243 1.00 43.71  ? 55  VAL A C   1 
ATOM   439   O O   . VAL A 1 55  ? 23.535  24.271  -20.619 1.00 44.40  ? 55  VAL A O   1 
ATOM   440   C CB  . VAL A 1 55  ? 21.314  26.419  -20.258 1.00 52.22  ? 55  VAL A CB  1 
ATOM   441   C CG1 . VAL A 1 55  ? 20.525  26.410  -21.560 1.00 54.53  ? 55  VAL A CG1 1 
ATOM   442   C CG2 . VAL A 1 55  ? 20.935  25.188  -19.421 1.00 52.23  ? 55  VAL A CG2 1 
ATOM   443   N N   . LEU A 1 56  ? 23.734  25.404  -22.540 1.00 44.88  ? 56  LEU A N   1 
ATOM   444   C CA  . LEU A 1 56  ? 24.029  24.207  -23.320 1.00 42.97  ? 56  LEU A CA  1 
ATOM   445   C C   . LEU A 1 56  ? 25.519  23.987  -23.548 1.00 46.40  ? 56  LEU A C   1 
ATOM   446   O O   . LEU A 1 56  ? 25.883  22.858  -23.877 1.00 49.20  ? 56  LEU A O   1 
ATOM   447   C CB  . LEU A 1 56  ? 23.322  24.200  -24.676 1.00 43.07  ? 56  LEU A CB  1 
ATOM   448   C CG  . LEU A 1 56  ? 21.792  24.190  -24.643 1.00 38.48  ? 56  LEU A CG  1 
ATOM   449   C CD1 . LEU A 1 56  ? 21.265  23.943  -26.030 1.00 40.64  ? 56  LEU A CD1 1 
ATOM   450   C CD2 . LEU A 1 56  ? 21.211  23.155  -23.699 1.00 41.61  ? 56  LEU A CD2 1 
ATOM   451   N N   . THR A 1 57  ? 26.369  25.019  -23.426 1.00 47.72  ? 57  THR A N   1 
ATOM   452   C CA  . THR A 1 57  ? 27.754  24.896  -23.894 1.00 48.81  ? 57  THR A CA  1 
ATOM   453   C C   . THR A 1 57  ? 28.716  25.374  -22.820 1.00 46.61  ? 57  THR A C   1 
ATOM   454   O O   . THR A 1 57  ? 28.298  25.998  -21.860 1.00 45.84  ? 57  THR A O   1 
ATOM   455   C CB  . THR A 1 57  ? 27.970  25.687  -25.181 1.00 47.63  ? 57  THR A CB  1 
ATOM   456   O OG1 . THR A 1 57  ? 27.811  27.059  -24.826 1.00 52.73  ? 57  THR A OG1 1 
ATOM   457   C CG2 . THR A 1 57  ? 26.976  25.305  -26.260 1.00 44.71  ? 57  THR A CG2 1 
ATOM   458   N N   . PHE A 1 58  ? 29.998  25.045  -22.980 1.00 48.62  ? 58  PHE A N   1 
ATOM   459   C CA  . PHE A 1 58  ? 31.024  25.553  -22.085 1.00 51.79  ? 58  PHE A CA  1 
ATOM   460   C C   . PHE A 1 58  ? 32.344  25.611  -22.840 1.00 57.42  ? 58  PHE A C   1 
ATOM   461   O O   . PHE A 1 58  ? 32.456  24.989  -23.893 1.00 56.91  ? 58  PHE A O   1 
ATOM   462   C CB  . PHE A 1 58  ? 31.232  24.687  -20.840 1.00 49.52  ? 58  PHE A CB  1 
ATOM   463   C CG  . PHE A 1 58  ? 31.943  23.366  -21.115 1.00 47.85  ? 58  PHE A CG  1 
ATOM   464   C CD1 . PHE A 1 58  ? 31.354  22.395  -21.909 1.00 39.47  ? 58  PHE A CD1 1 
ATOM   465   C CD2 . PHE A 1 58  ? 33.199  23.095  -20.580 1.00 51.48  ? 58  PHE A CD2 1 
ATOM   466   C CE1 . PHE A 1 58  ? 32.002  21.204  -22.172 1.00 40.71  ? 58  PHE A CE1 1 
ATOM   467   C CE2 . PHE A 1 58  ? 33.850  21.895  -20.842 1.00 46.43  ? 58  PHE A CE2 1 
ATOM   468   C CZ  . PHE A 1 58  ? 33.248  20.953  -21.640 1.00 46.40  ? 58  PHE A CZ  1 
ATOM   469   N N   . VAL A 1 59  ? 33.333  26.308  -22.250 1.00 58.60  ? 59  VAL A N   1 
ATOM   470   C CA  . VAL A 1 59  ? 34.681  26.394  -22.790 1.00 60.11  ? 59  VAL A CA  1 
ATOM   471   C C   . VAL A 1 59  ? 35.641  25.467  -22.035 1.00 54.65  ? 59  VAL A C   1 
ATOM   472   O O   . VAL A 1 59  ? 35.826  25.603  -20.836 1.00 56.54  ? 59  VAL A O   1 
ATOM   473   C CB  . VAL A 1 59  ? 35.122  27.860  -22.732 1.00 63.00  ? 59  VAL A CB  1 
ATOM   474   C CG1 . VAL A 1 59  ? 36.525  28.015  -23.306 1.00 67.52  ? 59  VAL A CG1 1 
ATOM   475   C CG2 . VAL A 1 59  ? 34.131  28.762  -23.463 1.00 58.45  ? 59  VAL A CG2 1 
ATOM   476   N N   . ASP A 1 60  ? 36.247  24.509  -22.744 1.00 49.09  ? 60  ASP A N   1 
ATOM   477   C CA  . ASP A 1 60  ? 36.950  23.390  -22.116 1.00 54.25  ? 60  ASP A CA  1 
ATOM   478   C C   . ASP A 1 60  ? 38.366  23.849  -21.782 1.00 63.38  ? 60  ASP A C   1 
ATOM   479   O O   . ASP A 1 60  ? 38.737  24.996  -22.047 1.00 56.45  ? 60  ASP A O   1 
ATOM   480   C CB  . ASP A 1 60  ? 36.941  22.149  -23.008 1.00 55.10  ? 60  ASP A CB  1 
ATOM   481   C CG  . ASP A 1 60  ? 37.249  20.783  -22.385 1.00 70.28  ? 60  ASP A CG  1 
ATOM   482   O OD1 . ASP A 1 60  ? 37.686  20.741  -21.198 1.00 71.39  ? 60  ASP A OD1 1 
ATOM   483   O OD2 . ASP A 1 60  ? 37.054  19.740  -23.095 1.00 53.69  ? 60  ASP A OD2 1 
ATOM   484   N N   . ASP A 1 61  ? 39.140  22.939  -21.178 1.00 77.84  ? 61  ASP A N   1 
ATOM   485   C CA  . ASP A 1 61  ? 40.520  23.197  -20.786 1.00 78.14  ? 61  ASP A CA  1 
ATOM   486   C C   . ASP A 1 61  ? 41.299  23.689  -22.005 1.00 74.08  ? 61  ASP A C   1 
ATOM   487   O O   . ASP A 1 61  ? 41.779  24.817  -22.014 1.00 79.15  ? 61  ASP A O   1 
ATOM   488   C CB  . ASP A 1 61  ? 41.086  21.976  -20.076 1.00 77.98  ? 61  ASP A CB  1 
ATOM   489   C CG  . ASP A 1 61  ? 40.405  21.640  -18.752 1.00 76.55  ? 61  ASP A CG  1 
ATOM   490   O OD1 . ASP A 1 61  ? 39.598  22.478  -18.282 1.00 66.49  ? 61  ASP A OD1 1 
ATOM   491   O OD2 . ASP A 1 61  ? 40.677  20.547  -18.200 1.00 62.79  ? 61  ASP A OD2 1 
ATOM   492   N N   . ASP A 1 62  ? 41.305  22.884  -23.073 1.00 79.63  ? 62  ASP A N   1 
ATOM   493   C CA  . ASP A 1 62  ? 41.935  23.242  -24.341 1.00 77.44  ? 62  ASP A CA  1 
ATOM   494   C C   . ASP A 1 62  ? 41.451  24.566  -24.945 1.00 67.16  ? 62  ASP A C   1 
ATOM   495   O O   . ASP A 1 62  ? 41.918  24.912  -26.016 1.00 75.49  ? 62  ASP A O   1 
ATOM   496   C CB  . ASP A 1 62  ? 41.754  22.144  -25.383 1.00 76.71  ? 62  ASP A CB  1 
ATOM   497   C CG  . ASP A 1 62  ? 40.314  21.777  -25.725 1.00 83.83  ? 62  ASP A CG  1 
ATOM   498   O OD1 . ASP A 1 62  ? 39.459  22.699  -25.789 1.00 85.79  ? 62  ASP A OD1 1 
ATOM   499   O OD2 . ASP A 1 62  ? 40.058  20.572  -25.936 1.00 65.47  ? 62  ASP A OD2 1 
ATOM   500   N N   . GLY A 1 63  ? 40.510  25.295  -24.333 1.00 69.76  ? 63  GLY A N   1 
ATOM   501   C CA  . GLY A 1 63  ? 40.092  26.592  -24.856 1.00 67.41  ? 63  GLY A CA  1 
ATOM   502   C C   . GLY A 1 63  ? 38.960  26.516  -25.894 1.00 69.08  ? 63  GLY A C   1 
ATOM   503   O O   . GLY A 1 63  ? 38.483  27.554  -26.362 1.00 64.22  ? 63  GLY A O   1 
ATOM   504   N N   . VAL A 1 64  ? 38.498  25.306  -26.247 1.00 64.55  ? 64  VAL A N   1 
ATOM   505   C CA  . VAL A 1 64  ? 37.480  25.131  -27.286 1.00 67.61  ? 64  VAL A CA  1 
ATOM   506   C C   . VAL A 1 64  ? 36.072  25.136  -26.666 1.00 60.20  ? 64  VAL A C   1 
ATOM   507   O O   . VAL A 1 64  ? 35.874  24.587  -25.589 1.00 59.15  ? 64  VAL A O   1 
ATOM   508   C CB  . VAL A 1 64  ? 37.754  23.802  -28.029 1.00 65.31  ? 64  VAL A CB  1 
ATOM   509   C CG1 . VAL A 1 64  ? 36.673  23.472  -29.047 1.00 63.44  ? 64  VAL A CG1 1 
ATOM   510   C CG2 . VAL A 1 64  ? 39.123  23.774  -28.700 1.00 59.51  ? 64  VAL A CG2 1 
ATOM   511   N N   . ARG A 1 65  ? 35.079  25.714  -27.356 1.00 53.36  ? 65  ARG A N   1 
ATOM   512   C CA  . ARG A 1 65  ? 33.688  25.661  -26.912 1.00 52.90  ? 65  ARG A CA  1 
ATOM   513   C C   . ARG A 1 65  ? 33.039  24.328  -27.295 1.00 52.96  ? 65  ARG A C   1 
ATOM   514   O O   . ARG A 1 65  ? 32.994  23.974  -28.474 1.00 51.96  ? 65  ARG A O   1 
ATOM   515   C CB  . ARG A 1 65  ? 32.806  26.753  -27.518 1.00 52.47  ? 65  ARG A CB  1 
ATOM   516   C CG  . ARG A 1 65  ? 31.377  26.680  -26.994 1.00 59.81  ? 65  ARG A CG  1 
ATOM   517   C CD  . ARG A 1 65  ? 30.468  27.823  -27.459 1.00 57.67  ? 65  ARG A CD  1 
ATOM   518   N NE  . ARG A 1 65  ? 30.941  29.110  -26.944 1.00 58.70  ? 65  ARG A NE  1 
ATOM   519   C CZ  . ARG A 1 65  ? 30.952  29.480  -25.673 1.00 67.91  ? 65  ARG A CZ  1 
ATOM   520   N NH1 . ARG A 1 65  ? 30.284  28.808  -24.754 1.00 70.25  ? 65  ARG A NH1 1 
ATOM   521   N NH2 . ARG A 1 65  ? 31.597  30.570  -25.317 1.00 71.28  ? 65  ARG A NH2 1 
ATOM   522   N N   . LYS A 1 66  ? 32.511  23.613  -26.283 1.00 50.82  ? 66  LYS A N   1 
ATOM   523   C CA  . LYS A 1 66  ? 31.930  22.290  -26.463 1.00 45.29  ? 66  LYS A CA  1 
ATOM   524   C C   . LYS A 1 66  ? 30.578  22.188  -25.765 1.00 44.29  ? 66  LYS A C   1 
ATOM   525   O O   . LYS A 1 66  ? 30.227  23.027  -24.942 1.00 47.42  ? 66  LYS A O   1 
ATOM   526   C CB  . LYS A 1 66  ? 32.836  21.195  -25.909 1.00 47.82  ? 66  LYS A CB  1 
ATOM   527   C CG  . LYS A 1 66  ? 34.230  21.234  -26.479 1.00 51.82  ? 66  LYS A CG  1 
ATOM   528   C CD  . LYS A 1 66  ? 35.178  20.160  -25.969 1.00 54.88  ? 66  LYS A CD  1 
ATOM   529   C CE  . LYS A 1 66  ? 36.601  20.434  -26.418 1.00 64.96  ? 66  LYS A CE  1 
ATOM   530   N NZ  . LYS A 1 66  ? 37.610  19.577  -25.785 1.00 63.95  ? 66  LYS A NZ  1 
ATOM   531   N N   . SER A 1 67  ? 29.836  21.137  -26.127 1.00 43.46  ? 67  SER A N   1 
ATOM   532   C CA  . SER A 1 67  ? 28.534  20.838  -25.571 1.00 42.15  ? 67  SER A CA  1 
ATOM   533   C C   . SER A 1 67  ? 28.679  20.320  -24.142 1.00 39.90  ? 67  SER A C   1 
ATOM   534   O O   . SER A 1 67  ? 29.602  19.576  -23.863 1.00 39.76  ? 67  SER A O   1 
ATOM   535   C CB  . SER A 1 67  ? 27.837  19.835  -26.430 1.00 43.61  ? 67  SER A CB  1 
ATOM   536   O OG  . SER A 1 67  ? 27.518  20.400  -27.692 1.00 45.45  ? 67  SER A OG  1 
ATOM   537   N N   . MET A 1 68  ? 27.711  20.659  -23.277 1.00 34.33  ? 68  MET A N   1 
ATOM   538   C CA  . MET A 1 68  ? 27.713  20.246  -21.887 1.00 33.84  ? 68  MET A CA  1 
ATOM   539   C C   . MET A 1 68  ? 27.620  18.726  -21.752 1.00 32.64  ? 68  MET A C   1 
ATOM   540   O O   . MET A 1 68  ? 27.954  18.172  -20.705 1.00 33.24  ? 68  MET A O   1 
ATOM   541   C CB  . MET A 1 68  ? 26.602  20.970  -21.123 1.00 33.95  ? 68  MET A CB  1 
ATOM   542   C CG  . MET A 1 68  ? 26.941  22.442  -20.839 1.00 39.52  ? 68  MET A CG  1 
ATOM   543   S SD  . MET A 1 68  ? 28.135  22.645  -19.500 1.00 47.06  ? 68  MET A SD  1 
ATOM   544   C CE  . MET A 1 68  ? 26.869  22.378  -18.250 1.00 51.73  ? 68  MET A CE  1 
ATOM   545   N N   . HIS A 1 69  ? 27.257  18.016  -22.818 1.00 33.47  ? 69  HIS A N   1 
ATOM   546   C CA  . HIS A 1 69  ? 27.302  16.568  -22.719 1.00 34.07  ? 69  HIS A CA  1 
ATOM   547   C C   . HIS A 1 69  ? 28.739  16.102  -22.526 1.00 37.24  ? 69  HIS A C   1 
ATOM   548   O O   . HIS A 1 69  ? 28.935  14.936  -22.185 1.00 46.01  ? 69  HIS A O   1 
ATOM   549   C CB  . HIS A 1 69  ? 26.497  15.887  -23.828 1.00 37.28  ? 69  HIS A CB  1 
ATOM   550   C CG  . HIS A 1 69  ? 26.885  16.172  -25.226 1.00 39.60  ? 69  HIS A CG  1 
ATOM   551   N ND1 . HIS A 1 69  ? 25.914  16.330  -26.193 1.00 41.32  ? 69  HIS A ND1 1 
ATOM   552   C CD2 . HIS A 1 69  ? 28.078  16.294  -25.848 1.00 41.75  ? 69  HIS A CD2 1 
ATOM   553   C CE1 . HIS A 1 69  ? 26.511  16.560  -27.362 1.00 43.12  ? 69  HIS A CE1 1 
ATOM   554   N NE2 . HIS A 1 69  ? 27.830  16.533  -27.174 1.00 42.10  ? 69  HIS A NE2 1 
ATOM   555   N N   . TRP A 1 70  ? 29.731  16.996  -22.679 1.00 34.26  ? 70  TRP A N   1 
ATOM   556   C CA  . TRP A 1 70  ? 31.118  16.624  -22.404 1.00 36.98  ? 70  TRP A CA  1 
ATOM   557   C C   . TRP A 1 70  ? 31.672  17.283  -21.138 1.00 35.92  ? 70  TRP A C   1 
ATOM   558   O O   . TRP A 1 70  ? 32.850  17.145  -20.879 1.00 36.43  ? 70  TRP A O   1 
ATOM   559   C CB  . TRP A 1 70  ? 32.028  17.011  -23.577 1.00 35.75  ? 70  TRP A CB  1 
ATOM   560   C CG  . TRP A 1 70  ? 31.701  16.364  -24.890 1.00 29.39  ? 70  TRP A CG  1 
ATOM   561   C CD1 . TRP A 1 70  ? 31.455  17.017  -26.056 1.00 28.16  ? 70  TRP A CD1 1 
ATOM   562   C CD2 . TRP A 1 70  ? 31.653  14.956  -25.193 1.00 27.10  ? 70  TRP A CD2 1 
ATOM   563   N NE1 . TRP A 1 70  ? 31.212  16.121  -27.059 1.00 28.91  ? 70  TRP A NE1 1 
ATOM   564   C CE2 . TRP A 1 70  ? 31.343  14.849  -26.555 1.00 27.04  ? 70  TRP A CE2 1 
ATOM   565   C CE3 . TRP A 1 70  ? 31.812  13.791  -24.454 1.00 29.40  ? 70  TRP A CE3 1 
ATOM   566   C CZ2 . TRP A 1 70  ? 31.207  13.618  -27.177 1.00 29.96  ? 70  TRP A CZ2 1 
ATOM   567   C CZ3 . TRP A 1 70  ? 31.708  12.570  -25.078 1.00 27.81  ? 70  TRP A CZ3 1 
ATOM   568   C CH2 . TRP A 1 70  ? 31.395  12.484  -26.417 1.00 29.61  ? 70  TRP A CH2 1 
ATOM   569   N N   . PHE A 1 71  ? 30.837  17.932  -20.322 1.00 37.74  ? 71  PHE A N   1 
ATOM   570   C CA  . PHE A 1 71  ? 31.303  18.720  -19.188 1.00 38.66  ? 71  PHE A CA  1 
ATOM   571   C C   . PHE A 1 71  ? 31.451  17.857  -17.933 1.00 38.57  ? 71  PHE A C   1 
ATOM   572   O O   . PHE A 1 71  ? 30.471  17.388  -17.398 1.00 41.20  ? 71  PHE A O   1 
ATOM   573   C CB  . PHE A 1 71  ? 30.305  19.865  -18.984 1.00 42.67  ? 71  PHE A CB  1 
ATOM   574   C CG  . PHE A 1 71  ? 30.602  20.811  -17.826 1.00 45.53  ? 71  PHE A CG  1 
ATOM   575   C CD1 . PHE A 1 71  ? 31.625  21.737  -17.903 1.00 49.84  ? 71  PHE A CD1 1 
ATOM   576   C CD2 . PHE A 1 71  ? 29.831  20.798  -16.671 1.00 46.53  ? 71  PHE A CD2 1 
ATOM   577   C CE1 . PHE A 1 71  ? 31.876  22.604  -16.852 1.00 44.95  ? 71  PHE A CE1 1 
ATOM   578   C CE2 . PHE A 1 71  ? 30.100  21.654  -15.611 1.00 43.53  ? 71  PHE A CE2 1 
ATOM   579   C CZ  . PHE A 1 71  ? 31.107  22.562  -15.711 1.00 43.34  ? 71  PHE A CZ  1 
ATOM   580   N N   . LEU A 1 72  ? 32.679  17.713  -17.431 1.00 42.30  ? 72  LEU A N   1 
ATOM   581   C CA  . LEU A 1 72  ? 32.943  17.065  -16.159 1.00 47.32  ? 72  LEU A CA  1 
ATOM   582   C C   . LEU A 1 72  ? 32.827  18.060  -15.010 1.00 47.54  ? 72  LEU A C   1 
ATOM   583   O O   . LEU A 1 72  ? 33.544  19.042  -14.990 1.00 46.09  ? 72  LEU A O   1 
ATOM   584   C CB  . LEU A 1 72  ? 34.358  16.530  -16.274 1.00 47.12  ? 72  LEU A CB  1 
ATOM   585   C CG  . LEU A 1 72  ? 34.576  15.602  -17.463 1.00 49.83  ? 72  LEU A CG  1 
ATOM   586   C CD1 . LEU A 1 72  ? 36.052  15.309  -17.553 1.00 52.63  ? 72  LEU A CD1 1 
ATOM   587   C CD2 . LEU A 1 72  ? 33.752  14.341  -17.290 1.00 49.49  ? 72  LEU A CD2 1 
ATOM   588   N N   . PRO A 1 73  ? 31.905  17.868  -14.043 1.00 46.45  ? 73  PRO A N   1 
ATOM   589   C CA  . PRO A 1 73  ? 31.747  18.811  -12.937 1.00 47.46  ? 73  PRO A CA  1 
ATOM   590   C C   . PRO A 1 73  ? 32.824  18.700  -11.864 1.00 44.18  ? 73  PRO A C   1 
ATOM   591   O O   . PRO A 1 73  ? 33.241  17.603  -11.518 1.00 42.44  ? 73  PRO A O   1 
ATOM   592   C CB  . PRO A 1 73  ? 30.377  18.416  -12.406 1.00 44.61  ? 73  PRO A CB  1 
ATOM   593   C CG  . PRO A 1 73  ? 30.314  16.936  -12.640 1.00 44.17  ? 73  PRO A CG  1 
ATOM   594   C CD  . PRO A 1 73  ? 30.942  16.764  -13.993 1.00 42.40  ? 73  PRO A CD  1 
ATOM   595   N N   . ARG A 1 74  ? 33.266  19.844  -11.347 1.00 42.51  ? 74  ARG A N   1 
ATOM   596   C CA  . ARG A 1 74  ? 34.363  19.858  -10.390 1.00 52.47  ? 74  ARG A CA  1 
ATOM   597   C C   . ARG A 1 74  ? 33.962  20.600  -9.122  1.00 48.46  ? 74  ARG A C   1 
ATOM   598   O O   . ARG A 1 74  ? 34.803  20.864  -8.277  1.00 48.24  ? 74  ARG A O   1 
ATOM   599   C CB  . ARG A 1 74  ? 35.581  20.555  -11.011 1.00 52.09  ? 74  ARG A CB  1 
ATOM   600   C CG  . ARG A 1 74  ? 36.148  19.821  -12.216 1.00 57.21  ? 74  ARG A CG  1 
ATOM   601   C CD  . ARG A 1 74  ? 37.323  20.512  -12.858 1.00 59.02  ? 74  ARG A CD  1 
ATOM   602   N NE  . ARG A 1 74  ? 38.058  19.545  -13.676 1.00 64.92  ? 74  ARG A NE  1 
ATOM   603   C CZ  . ARG A 1 74  ? 38.579  19.768  -14.887 1.00 79.31  ? 74  ARG A CZ  1 
ATOM   604   N NH1 . ARG A 1 74  ? 38.381  20.910  -15.532 1.00 75.54  ? 74  ARG A NH1 1 
ATOM   605   N NH2 . ARG A 1 74  ? 39.313  18.830  -15.460 1.00 82.20  ? 74  ARG A NH2 1 
ATOM   606   N N   . SER A 1 75  ? 32.681  20.926  -8.996  1.00 42.62  ? 75  SER A N   1 
ATOM   607   C CA  . SER A 1 75  ? 32.188  21.601  -7.818  1.00 43.76  ? 75  SER A CA  1 
ATOM   608   C C   . SER A 1 75  ? 30.700  21.337  -7.720  1.00 43.18  ? 75  SER A C   1 
ATOM   609   O O   . SER A 1 75  ? 30.092  20.912  -8.684  1.00 47.51  ? 75  SER A O   1 
ATOM   610   C CB  . SER A 1 75  ? 32.428  23.072  -7.894  1.00 41.45  ? 75  SER A CB  1 
ATOM   611   O OG  . SER A 1 75  ? 31.599  23.626  -8.905  1.00 45.79  ? 75  SER A OG  1 
ATOM   612   N N   . LYS A 1 76  ? 30.122  21.688  -6.579  1.00 44.13  ? 76  LYS A N   1 
ATOM   613   C CA  . LYS A 1 76  ? 28.691  21.606  -6.403  1.00 42.35  ? 76  LYS A CA  1 
ATOM   614   C C   . LYS A 1 76  ? 28.011  22.478  -7.445  1.00 42.77  ? 76  LYS A C   1 
ATOM   615   O O   . LYS A 1 76  ? 26.981  22.112  -7.988  1.00 45.44  ? 76  LYS A O   1 
ATOM   616   C CB  . LYS A 1 76  ? 28.392  21.995  -4.957  1.00 41.29  ? 76  LYS A CB  1 
ATOM   617   C CG  . LYS A 1 76  ? 26.938  21.827  -4.535  1.00 43.51  ? 76  LYS A CG  1 
ATOM   618   C CD  . LYS A 1 76  ? 26.702  22.123  -3.059  1.00 44.12  ? 76  LYS A CD  1 
ATOM   619   C CE  . LYS A 1 76  ? 27.476  21.168  -2.179  1.00 48.75  ? 76  LYS A CE  1 
ATOM   620   N NZ  . LYS A 1 76  ? 27.496  21.574  -0.765  1.00 53.37  ? 76  LYS A NZ  1 
ATOM   621   N N   . ALA A 1 77  ? 28.608  23.627  -7.760  1.00 45.54  ? 77  ALA A N   1 
ATOM   622   C CA  . ALA A 1 77  ? 27.954  24.564  -8.665  1.00 41.88  ? 77  ALA A CA  1 
ATOM   623   C C   . ALA A 1 77  ? 27.956  24.002  -10.082 1.00 39.88  ? 77  ALA A C   1 
ATOM   624   O O   . ALA A 1 77  ? 27.023  24.231  -10.840 1.00 39.69  ? 77  ALA A O   1 
ATOM   625   C CB  . ALA A 1 77  ? 28.620  25.932  -8.605  1.00 36.58  ? 77  ALA A CB  1 
ATOM   626   N N   . ASP A 1 78  ? 29.029  23.293  -10.430 1.00 41.22  ? 78  ASP A N   1 
ATOM   627   C CA  . ASP A 1 78  ? 29.114  22.606  -11.711 1.00 47.06  ? 78  ASP A CA  1 
ATOM   628   C C   . ASP A 1 78  ? 28.019  21.541  -11.821 1.00 43.77  ? 78  ASP A C   1 
ATOM   629   O O   . ASP A 1 78  ? 27.275  21.492  -12.797 1.00 41.31  ? 78  ASP A O   1 
ATOM   630   C CB  . ASP A 1 78  ? 30.499  22.007  -11.912 1.00 47.87  ? 78  ASP A CB  1 
ATOM   631   C CG  . ASP A 1 78  ? 31.620  22.994  -12.233 1.00 47.46  ? 78  ASP A CG  1 
ATOM   632   O OD1 . ASP A 1 78  ? 31.348  24.205  -12.351 1.00 46.84  ? 78  ASP A OD1 1 
ATOM   633   O OD2 . ASP A 1 78  ? 32.759  22.542  -12.412 1.00 50.80  ? 78  ASP A OD2 1 
ATOM   634   N N   . ALA A 1 79  ? 27.892  20.715  -10.782 1.00 41.42  ? 79  ALA A N   1 
ATOM   635   C CA  . ALA A 1 79  ? 26.834  19.720  -10.707 1.00 41.71  ? 79  ALA A CA  1 
ATOM   636   C C   . ALA A 1 79  ? 25.456  20.347  -10.914 1.00 41.17  ? 79  ALA A C   1 
ATOM   637   O O   . ALA A 1 79  ? 24.614  19.739  -11.568 1.00 40.83  ? 79  ALA A O   1 
ATOM   638   C CB  . ALA A 1 79  ? 26.895  19.002  -9.385  1.00 43.82  ? 79  ALA A CB  1 
ATOM   639   N N   . ALA A 1 80  ? 25.233  21.552  -10.371 1.00 40.22  ? 80  ALA A N   1 
ATOM   640   C CA  . ALA A 1 80  ? 23.923  22.188  -10.445 1.00 42.51  ? 80  ALA A CA  1 
ATOM   641   C C   . ALA A 1 80  ? 23.663  22.654  -11.871 1.00 44.60  ? 80  ALA A C   1 
ATOM   642   O O   . ALA A 1 80  ? 22.513  22.729  -12.309 1.00 44.45  ? 80  ALA A O   1 
ATOM   643   C CB  . ALA A 1 80  ? 23.792  23.350  -9.459  1.00 38.33  ? 80  ALA A CB  1 
ATOM   644   N N   . ARG A 1 81  ? 24.751  22.956  -12.583 1.00 46.22  ? 81  ARG A N   1 
ATOM   645   C CA  . ARG A 1 81  ? 24.667  23.446  -13.949 1.00 44.37  ? 81  ARG A CA  1 
ATOM   646   C C   . ARG A 1 81  ? 24.406  22.242  -14.847 1.00 40.24  ? 81  ARG A C   1 
ATOM   647   O O   . ARG A 1 81  ? 23.677  22.315  -15.828 1.00 43.05  ? 81  ARG A O   1 
ATOM   648   C CB  . ARG A 1 81  ? 25.970  24.223  -14.180 1.00 47.22  ? 81  ARG A CB  1 
ATOM   649   C CG  . ARG A 1 81  ? 26.145  24.926  -15.510 1.00 55.00  ? 81  ARG A CG  1 
ATOM   650   C CD  . ARG A 1 81  ? 27.539  25.534  -15.630 1.00 61.55  ? 81  ARG A CD  1 
ATOM   651   N NE  . ARG A 1 81  ? 27.948  25.704  -17.034 1.00 60.75  ? 81  ARG A NE  1 
ATOM   652   C CZ  . ARG A 1 81  ? 29.121  26.187  -17.448 1.00 54.62  ? 81  ARG A CZ  1 
ATOM   653   N NH1 . ARG A 1 81  ? 30.105  26.424  -16.602 1.00 64.67  ? 81  ARG A NH1 1 
ATOM   654   N NH2 . ARG A 1 81  ? 29.318  26.430  -18.721 1.00 56.90  ? 81  ARG A NH2 1 
ATOM   655   N N   . ARG A 1 82  ? 24.967  21.094  -14.475 1.00 39.35  ? 82  ARG A N   1 
ATOM   656   C CA  . ARG A 1 82  ? 24.655  19.863  -15.187 1.00 37.38  ? 82  ARG A CA  1 
ATOM   657   C C   . ARG A 1 82  ? 23.196  19.482  -14.979 1.00 37.69  ? 82  ARG A C   1 
ATOM   658   O O   . ARG A 1 82  ? 22.515  19.051  -15.903 1.00 42.17  ? 82  ARG A O   1 
ATOM   659   C CB  . ARG A 1 82  ? 25.592  18.756  -14.720 1.00 37.97  ? 82  ARG A CB  1 
ATOM   660   C CG  . ARG A 1 82  ? 26.982  18.867  -15.317 1.00 37.31  ? 82  ARG A CG  1 
ATOM   661   C CD  . ARG A 1 82  ? 27.699  17.547  -15.178 1.00 39.71  ? 82  ARG A CD  1 
ATOM   662   N NE  . ARG A 1 82  ? 26.945  16.548  -15.934 1.00 38.03  ? 82  ARG A NE  1 
ATOM   663   C CZ  . ARG A 1 82  ? 26.912  16.527  -17.250 1.00 46.73  ? 82  ARG A CZ  1 
ATOM   664   N NH1 . ARG A 1 82  ? 27.821  17.171  -17.975 1.00 45.65  ? 82  ARG A NH1 1 
ATOM   665   N NH2 . ARG A 1 82  ? 26.009  15.779  -17.840 1.00 47.55  ? 82  ARG A NH2 1 
ATOM   666   N N   . ARG A 1 83  ? 22.709  19.689  -13.761 1.00 37.22  ? 83  ARG A N   1 
ATOM   667   C CA  . ARG A 1 83  ? 21.328  19.367  -13.461 1.00 40.15  ? 83  ARG A CA  1 
ATOM   668   C C   . ARG A 1 83  ? 20.433  20.208  -14.353 1.00 37.62  ? 83  ARG A C   1 
ATOM   669   O O   . ARG A 1 83  ? 19.502  19.695  -14.946 1.00 38.24  ? 83  ARG A O   1 
ATOM   670   C CB  . ARG A 1 83  ? 21.070  19.556  -11.964 1.00 42.31  ? 83  ARG A CB  1 
ATOM   671   C CG  . ARG A 1 83  ? 19.705  19.115  -11.459 1.00 43.68  ? 83  ARG A CG  1 
ATOM   672   C CD  . ARG A 1 83  ? 19.684  18.656  -10.010 1.00 45.26  ? 83  ARG A CD  1 
ATOM   673   N NE  . ARG A 1 83  ? 20.252  19.706  -9.167  1.00 49.27  ? 83  ARG A NE  1 
ATOM   674   C CZ  . ARG A 1 83  ? 19.590  20.676  -8.571  1.00 50.79  ? 83  ARG A CZ  1 
ATOM   675   N NH1 . ARG A 1 83  ? 18.280  20.676  -8.567  1.00 49.90  ? 83  ARG A NH1 1 
ATOM   676   N NH2 . ARG A 1 83  ? 20.256  21.623  -7.942  1.00 52.13  ? 83  ARG A NH2 1 
ATOM   677   N N   . ALA A 1 84  ? 20.747  21.499  -14.465 1.00 37.83  ? 84  ALA A N   1 
ATOM   678   C CA  . ALA A 1 84  ? 19.954  22.394  -15.296 1.00 39.04  ? 84  ALA A CA  1 
ATOM   679   C C   . ALA A 1 84  ? 19.989  21.956  -16.746 1.00 38.14  ? 84  ALA A C   1 
ATOM   680   O O   . ALA A 1 84  ? 19.013  22.153  -17.455 1.00 48.84  ? 84  ALA A O   1 
ATOM   681   C CB  . ALA A 1 84  ? 20.416  23.840  -15.193 1.00 35.04  ? 84  ALA A CB  1 
ATOM   682   N N   . TYR A 1 85  ? 21.146  21.449  -17.173 1.00 39.56  ? 85  TYR A N   1 
ATOM   683   C CA  . TYR A 1 85  ? 21.314  20.943  -18.522 1.00 40.66  ? 85  TYR A CA  1 
ATOM   684   C C   . TYR A 1 85  ? 20.456  19.698  -18.746 1.00 38.20  ? 85  TYR A C   1 
ATOM   685   O O   . TYR A 1 85  ? 19.864  19.548  -19.806 1.00 35.93  ? 85  TYR A O   1 
ATOM   686   C CB  . TYR A 1 85  ? 22.787  20.597  -18.779 1.00 37.68  ? 85  TYR A CB  1 
ATOM   687   C CG  . TYR A 1 85  ? 23.138  20.021  -20.152 1.00 34.66  ? 85  TYR A CG  1 
ATOM   688   C CD1 . TYR A 1 85  ? 23.147  20.803  -21.291 1.00 34.27  ? 85  TYR A CD1 1 
ATOM   689   C CD2 . TYR A 1 85  ? 23.536  18.711  -20.290 1.00 31.17  ? 85  TYR A CD2 1 
ATOM   690   C CE1 . TYR A 1 85  ? 23.509  20.287  -22.525 1.00 34.79  ? 85  TYR A CE1 1 
ATOM   691   C CE2 . TYR A 1 85  ? 23.943  18.193  -21.504 1.00 35.54  ? 85  TYR A CE2 1 
ATOM   692   C CZ  . TYR A 1 85  ? 23.916  18.976  -22.633 1.00 36.38  ? 85  TYR A CZ  1 
ATOM   693   O OH  . TYR A 1 85  ? 24.308  18.433  -23.821 1.00 41.18  ? 85  TYR A OH  1 
ATOM   694   N N   . HIS A 1 86  ? 20.440  18.760  -17.799 1.00 37.98  ? 86  HIS A N   1 
ATOM   695   C CA  . HIS A 1 86  ? 19.630  17.562  -18.004 1.00 40.72  ? 86  HIS A CA  1 
ATOM   696   C C   . HIS A 1 86  ? 18.147  17.968  -18.037 1.00 41.87  ? 86  HIS A C   1 
ATOM   697   O O   . HIS A 1 86  ? 17.363  17.432  -18.816 1.00 40.14  ? 86  HIS A O   1 
ATOM   698   C CB  . HIS A 1 86  ? 19.981  16.506  -16.957 1.00 38.75  ? 86  HIS A CB  1 
ATOM   699   C CG  . HIS A 1 86  ? 21.328  15.847  -17.068 1.00 41.70  ? 86  HIS A CG  1 
ATOM   700   N ND1 . HIS A 1 86  ? 21.721  14.971  -18.068 1.00 39.62  ? 86  HIS A ND1 1 
ATOM   701   C CD2 . HIS A 1 86  ? 22.330  15.846  -16.151 1.00 41.87  ? 86  HIS A CD2 1 
ATOM   702   C CE1 . HIS A 1 86  ? 22.913  14.481  -17.765 1.00 38.96  ? 86  HIS A CE1 1 
ATOM   703   N NE2 . HIS A 1 86  ? 23.310  15.016  -16.606 1.00 39.67  ? 86  HIS A NE2 1 
ATOM   704   N N   . GLU A 1 87  ? 17.768  18.970  -17.239 1.00 41.25  ? 87  GLU A N   1 
ATOM   705   C CA  . GLU A 1 87  ? 16.384  19.420  -17.170 1.00 46.52  ? 87  GLU A CA  1 
ATOM   706   C C   . GLU A 1 87  ? 15.973  20.060  -18.483 1.00 45.62  ? 87  GLU A C   1 
ATOM   707   O O   . GLU A 1 87  ? 14.845  19.861  -18.951 1.00 45.72  ? 87  GLU A O   1 
ATOM   708   C CB  . GLU A 1 87  ? 16.114  20.472  -16.094 1.00 45.19  ? 87  GLU A CB  1 
ATOM   709   C CG  . GLU A 1 87  ? 16.358  19.940  -14.686 1.00 50.75  ? 87  GLU A CG  1 
ATOM   710   C CD  . GLU A 1 87  ? 15.329  20.386  -13.675 1.00 48.78  ? 87  GLU A CD  1 
ATOM   711   O OE1 . GLU A 1 87  ? 14.243  20.819  -14.095 1.00 52.36  ? 87  GLU A OE1 1 
ATOM   712   O OE2 . GLU A 1 87  ? 15.637  20.314  -12.482 1.00 47.45  ? 87  GLU A OE2 1 
ATOM   713   N N   . PHE A 1 88  ? 16.871  20.874  -19.049 1.00 41.25  ? 88  PHE A N   1 
ATOM   714   C CA  . PHE A 1 88  ? 16.573  21.489  -20.335 1.00 39.40  ? 88  PHE A CA  1 
ATOM   715   C C   . PHE A 1 88  ? 16.100  20.380  -21.272 1.00 38.06  ? 88  PHE A C   1 
ATOM   716   O O   . PHE A 1 88  ? 15.051  20.465  -21.880 1.00 39.58  ? 88  PHE A O   1 
ATOM   717   C CB  . PHE A 1 88  ? 17.830  22.186  -20.849 1.00 40.01  ? 88  PHE A CB  1 
ATOM   718   C CG  . PHE A 1 88  ? 17.637  22.944  -22.147 1.00 38.89  ? 88  PHE A CG  1 
ATOM   719   C CD1 . PHE A 1 88  ? 17.604  22.268  -23.359 1.00 37.80  ? 88  PHE A CD1 1 
ATOM   720   C CD2 . PHE A 1 88  ? 17.499  24.323  -22.148 1.00 38.62  ? 88  PHE A CD2 1 
ATOM   721   C CE1 . PHE A 1 88  ? 17.427  22.951  -24.542 1.00 35.21  ? 88  PHE A CE1 1 
ATOM   722   C CE2 . PHE A 1 88  ? 17.319  25.006  -23.343 1.00 38.38  ? 88  PHE A CE2 1 
ATOM   723   C CZ  . PHE A 1 88  ? 17.277  24.314  -24.534 1.00 37.80  ? 88  PHE A CZ  1 
ATOM   724   N N   . TRP A 1 89  ? 16.859  19.288  -21.318 1.00 35.51  ? 89  TRP A N   1 
ATOM   725   C CA  . TRP A 1 89  ? 16.576  18.245  -22.276 1.00 37.42  ? 89  TRP A CA  1 
ATOM   726   C C   . TRP A 1 89  ? 15.317  17.462  -21.926 1.00 36.28  ? 89  TRP A C   1 
ATOM   727   O O   . TRP A 1 89  ? 14.595  17.106  -22.835 1.00 35.80  ? 89  TRP A O   1 
ATOM   728   C CB  . TRP A 1 89  ? 17.810  17.358  -22.467 1.00 36.11  ? 89  TRP A CB  1 
ATOM   729   C CG  . TRP A 1 89  ? 18.825  18.110  -23.279 1.00 38.19  ? 89  TRP A CG  1 
ATOM   730   C CD1 . TRP A 1 89  ? 20.073  18.507  -22.905 1.00 34.52  ? 89  TRP A CD1 1 
ATOM   731   C CD2 . TRP A 1 89  ? 18.584  18.708  -24.570 1.00 34.98  ? 89  TRP A CD2 1 
ATOM   732   N NE1 . TRP A 1 89  ? 20.651  19.252  -23.896 1.00 34.74  ? 89  TRP A NE1 1 
ATOM   733   C CE2 . TRP A 1 89  ? 19.764  19.392  -24.929 1.00 35.06  ? 89  TRP A CE2 1 
ATOM   734   C CE3 . TRP A 1 89  ? 17.509  18.704  -25.460 1.00 33.68  ? 89  TRP A CE3 1 
ATOM   735   C CZ2 . TRP A 1 89  ? 19.889  20.077  -26.132 1.00 35.51  ? 89  TRP A CZ2 1 
ATOM   736   C CZ3 . TRP A 1 89  ? 17.623  19.391  -26.647 1.00 37.13  ? 89  TRP A CZ3 1 
ATOM   737   C CH2 . TRP A 1 89  ? 18.801  20.071  -26.976 1.00 40.86  ? 89  TRP A CH2 1 
ATOM   738   N N   . PHE A 1 90  ? 15.046  17.217  -20.647 1.00 37.57  ? 90  PHE A N   1 
ATOM   739   C CA  . PHE A 1 90  ? 13.881  16.436  -20.277 1.00 38.04  ? 90  PHE A CA  1 
ATOM   740   C C   . PHE A 1 90  ? 12.647  17.247  -20.602 1.00 36.15  ? 90  PHE A C   1 
ATOM   741   O O   . PHE A 1 90  ? 11.664  16.685  -21.046 1.00 42.99  ? 90  PHE A O   1 
ATOM   742   C CB  . PHE A 1 90  ? 13.945  15.994  -18.816 1.00 42.58  ? 90  PHE A CB  1 
ATOM   743   C CG  . PHE A 1 90  ? 15.159  15.144  -18.451 1.00 40.75  ? 90  PHE A CG  1 
ATOM   744   C CD1 . PHE A 1 90  ? 15.620  14.139  -19.287 1.00 47.46  ? 90  PHE A CD1 1 
ATOM   745   C CD2 . PHE A 1 90  ? 15.840  15.358  -17.260 1.00 47.75  ? 90  PHE A CD2 1 
ATOM   746   C CE1 . PHE A 1 90  ? 16.724  13.377  -18.947 1.00 48.82  ? 90  PHE A CE1 1 
ATOM   747   C CE2 . PHE A 1 90  ? 16.965  14.614  -16.939 1.00 46.76  ? 90  PHE A CE2 1 
ATOM   748   C CZ  . PHE A 1 90  ? 17.399  13.626  -17.777 1.00 47.20  ? 90  PHE A CZ  1 
ATOM   749   N N   . ARG A 1 91  ? 12.772  18.572  -20.482 1.00 40.21  ? 91  ARG A N   1 
ATOM   750   C CA  . ARG A 1 91  ? 11.706  19.507  -20.797 1.00 37.79  ? 91  ARG A CA  1 
ATOM   751   C C   . ARG A 1 91  ? 11.514  19.610  -22.305 1.00 36.79  ? 91  ARG A C   1 
ATOM   752   O O   . ARG A 1 91  ? 10.401  19.516  -22.805 1.00 39.38  ? 91  ARG A O   1 
ATOM   753   C CB  . ARG A 1 91  ? 11.970  20.855  -20.115 1.00 40.52  ? 91  ARG A CB  1 
ATOM   754   C CG  . ARG A 1 91  ? 11.771  20.755  -18.605 1.00 44.47  ? 91  ARG A CG  1 
ATOM   755   C CD  . ARG A 1 91  ? 11.835  22.044  -17.783 1.00 45.97  ? 91  ARG A CD  1 
ATOM   756   N NE  . ARG A 1 91  ? 12.146  21.732  -16.377 1.00 45.83  ? 91  ARG A NE  1 
ATOM   757   C CZ  . ARG A 1 91  ? 11.243  21.436  -15.427 1.00 51.70  ? 91  ARG A CZ  1 
ATOM   758   N NH1 . ARG A 1 91  ? 9.945   21.619  -15.660 1.00 46.17  ? 91  ARG A NH1 1 
ATOM   759   N NH2 . ARG A 1 91  ? 11.641  21.000  -14.237 1.00 42.36  ? 91  ARG A NH2 1 
ATOM   760   N N   . HIS A 1 92  ? 12.599  19.787  -23.042 1.00 37.85  ? 92  HIS A N   1 
ATOM   761   C CA  . HIS A 1 92  ? 12.527  19.870  -24.491 1.00 37.48  ? 92  HIS A CA  1 
ATOM   762   C C   . HIS A 1 92  ? 11.920  18.600  -25.091 1.00 40.11  ? 92  HIS A C   1 
ATOM   763   O O   . HIS A 1 92  ? 11.265  18.681  -26.118 1.00 42.91  ? 92  HIS A O   1 
ATOM   764   C CB  . HIS A 1 92  ? 13.921  20.149  -25.064 1.00 36.89  ? 92  HIS A CB  1 
ATOM   765   C CG  . HIS A 1 92  ? 13.975  20.046  -26.540 1.00 38.40  ? 92  HIS A CG  1 
ATOM   766   N ND1 . HIS A 1 92  ? 14.256  18.864  -27.203 1.00 42.73  ? 92  HIS A ND1 1 
ATOM   767   C CD2 . HIS A 1 92  ? 13.723  20.962  -27.473 1.00 44.61  ? 92  HIS A CD2 1 
ATOM   768   C CE1 . HIS A 1 92  ? 14.200  19.082  -28.510 1.00 43.69  ? 92  HIS A CE1 1 
ATOM   769   N NE2 . HIS A 1 92  ? 13.879  20.356  -28.700 1.00 45.60  ? 92  HIS A NE2 1 
ATOM   770   N N   . PHE A 1 93  ? 12.165  17.436  -24.463 1.00 43.48  ? 93  PHE A N   1 
ATOM   771   C CA  . PHE A 1 93  ? 11.572  16.162  -24.867 1.00 43.67  ? 93  PHE A CA  1 
ATOM   772   C C   . PHE A 1 93  ? 10.372  15.774  -23.988 1.00 44.28  ? 93  PHE A C   1 
ATOM   773   O O   . PHE A 1 93  ? 10.212  14.601  -23.645 1.00 46.92  ? 93  PHE A O   1 
ATOM   774   C CB  . PHE A 1 93  ? 12.611  15.042  -24.731 1.00 38.67  ? 93  PHE A CB  1 
ATOM   775   C CG  . PHE A 1 93  ? 13.774  15.091  -25.709 1.00 38.11  ? 93  PHE A CG  1 
ATOM   776   C CD1 . PHE A 1 93  ? 13.549  15.186  -27.065 1.00 32.53  ? 93  PHE A CD1 1 
ATOM   777   C CD2 . PHE A 1 93  ? 15.088  15.066  -25.260 1.00 39.41  ? 93  PHE A CD2 1 
ATOM   778   C CE1 . PHE A 1 93  ? 14.590  15.219  -27.957 1.00 32.22  ? 93  PHE A CE1 1 
ATOM   779   C CE2 . PHE A 1 93  ? 16.131  15.122  -26.166 1.00 38.82  ? 93  PHE A CE2 1 
ATOM   780   C CZ  . PHE A 1 93  ? 15.872  15.199  -27.510 1.00 37.02  ? 93  PHE A CZ  1 
ATOM   781   N N   . GLN A 1 94  ? 9.585   16.763  -23.541 1.00 45.32  ? 94  GLN A N   1 
ATOM   782   C CA  . GLN A 1 94  ? 8.209   16.564  -23.106 1.00 39.71  ? 94  GLN A CA  1 
ATOM   783   C C   . GLN A 1 94  ? 8.149   15.605  -21.931 1.00 45.90  ? 94  GLN A C   1 
ATOM   784   O O   . GLN A 1 94  ? 7.434   14.605  -21.942 1.00 51.50  ? 94  GLN A O   1 
ATOM   785   C CB  . GLN A 1 94  ? 7.416   16.127  -24.328 1.00 41.50  ? 94  GLN A CB  1 
ATOM   786   C CG  . GLN A 1 94  ? 7.669   17.072  -25.494 1.00 44.19  ? 94  GLN A CG  1 
ATOM   787   C CD  . GLN A 1 94  ? 6.536   17.136  -26.486 1.00 49.76  ? 94  GLN A CD  1 
ATOM   788   O OE1 . GLN A 1 94  ? 5.362   16.898  -26.163 1.00 51.89  ? 94  GLN A OE1 1 
ATOM   789   N NE2 . GLN A 1 94  ? 6.885   17.546  -27.695 1.00 47.40  ? 94  GLN A NE2 1 
ATOM   790   N N   . GLY A 1 95  ? 8.922   15.942  -20.910 1.00 47.99  ? 95  GLY A N   1 
ATOM   791   C CA  . GLY A 1 95  ? 8.868   15.213  -19.666 1.00 51.06  ? 95  GLY A CA  1 
ATOM   792   C C   . GLY A 1 95  ? 9.925   14.133  -19.671 1.00 47.40  ? 95  GLY A C   1 
ATOM   793   O O   . GLY A 1 95  ? 10.319  13.674  -18.608 1.00 48.27  ? 95  GLY A O   1 
ATOM   794   N N   . GLY A 1 96  ? 10.390  13.790  -20.879 1.00 46.49  ? 96  GLY A N   1 
ATOM   795   C CA  . GLY A 1 96  ? 11.492  12.853  -21.039 1.00 42.76  ? 96  GLY A CA  1 
ATOM   796   C C   . GLY A 1 96  ? 11.090  11.616  -21.839 1.00 38.89  ? 96  GLY A C   1 
ATOM   797   O O   . GLY A 1 96  ? 11.481  10.514  -21.487 1.00 42.59  ? 96  GLY A O   1 
ATOM   798   N N   . ILE A 1 97  ? 10.374  11.820  -22.948 1.00 38.02  ? 97  ILE A N   1 
ATOM   799   C CA  . ILE A 1 97  ? 9.895   10.717  -23.756 1.00 41.79  ? 97  ILE A CA  1 
ATOM   800   C C   . ILE A 1 97  ? 11.069  9.951   -24.356 1.00 44.63  ? 97  ILE A C   1 
ATOM   801   O O   . ILE A 1 97  ? 10.988  8.719   -24.501 1.00 43.50  ? 97  ILE A O   1 
ATOM   802   C CB  . ILE A 1 97  ? 8.902   11.196  -24.828 1.00 43.49  ? 97  ILE A CB  1 
ATOM   803   C CG1 . ILE A 1 97  ? 9.518   12.067  -25.871 1.00 41.37  ? 97  ILE A CG1 1 
ATOM   804   C CG2 . ILE A 1 97  ? 7.715   11.883  -24.161 1.00 44.90  ? 97  ILE A CG2 1 
ATOM   805   C CD1 . ILE A 1 97  ? 8.580   12.381  -27.028 1.00 41.33  ? 97  ILE A CD1 1 
ATOM   806   N N   . PHE A 1 98  ? 12.140  10.694  -24.674 1.00 39.48  ? 98  PHE A N   1 
ATOM   807   C CA  . PHE A 1 98  ? 13.398  10.096  -25.081 1.00 39.58  ? 98  PHE A CA  1 
ATOM   808   C C   . PHE A 1 98  ? 14.385  10.194  -23.930 1.00 38.61  ? 98  PHE A C   1 
ATOM   809   O O   . PHE A 1 98  ? 14.748  11.284  -23.557 1.00 39.47  ? 98  PHE A O   1 
ATOM   810   C CB  . PHE A 1 98  ? 13.912  10.840  -26.311 1.00 41.15  ? 98  PHE A CB  1 
ATOM   811   C CG  . PHE A 1 98  ? 12.978  10.872  -27.507 1.00 36.37  ? 98  PHE A CG  1 
ATOM   812   C CD1 . PHE A 1 98  ? 12.100  9.827   -27.773 1.00 41.00  ? 98  PHE A CD1 1 
ATOM   813   C CD2 . PHE A 1 98  ? 13.005  11.940  -28.380 1.00 33.63  ? 98  PHE A CD2 1 
ATOM   814   C CE1 . PHE A 1 98  ? 11.245  9.886   -28.871 1.00 42.33  ? 98  PHE A CE1 1 
ATOM   815   C CE2 . PHE A 1 98  ? 12.172  11.978  -29.483 1.00 36.44  ? 98  PHE A CE2 1 
ATOM   816   C CZ  . PHE A 1 98  ? 11.278  10.971  -29.714 1.00 36.19  ? 98  PHE A CZ  1 
ATOM   817   N N   . THR A 1 99  ? 14.826  9.049   -23.401 1.00 41.81  ? 99  THR A N   1 
ATOM   818   C CA  . THR A 1 99  ? 15.627  9.010   -22.194 1.00 46.07  ? 99  THR A CA  1 
ATOM   819   C C   . THR A 1 99  ? 17.135  9.008   -22.484 1.00 49.46  ? 99  THR A C   1 
ATOM   820   O O   . THR A 1 99  ? 17.928  9.095   -21.535 1.00 49.23  ? 99  THR A O   1 
ATOM   821   C CB  . THR A 1 99  ? 15.237  7.782   -21.372 1.00 52.60  ? 99  THR A CB  1 
ATOM   822   O OG1 . THR A 1 99  ? 15.430  6.632   -22.179 1.00 52.47  ? 99  THR A OG1 1 
ATOM   823   C CG2 . THR A 1 99  ? 13.796  7.815   -20.902 1.00 56.94  ? 99  THR A CG2 1 
ATOM   824   N N   . ARG A 1 100 ? 17.545  8.940   -23.763 1.00 40.36  ? 100 ARG A N   1 
ATOM   825   C CA  . ARG A 1 100 ? 18.933  8.637   -24.074 1.00 40.05  ? 100 ARG A CA  1 
ATOM   826   C C   . ARG A 1 100 ? 19.408  9.390   -25.302 1.00 36.24  ? 100 ARG A C   1 
ATOM   827   O O   . ARG A 1 100 ? 19.898  8.787   -26.235 1.00 39.36  ? 100 ARG A O   1 
ATOM   828   C CB  . ARG A 1 100 ? 19.122  7.123   -24.246 1.00 44.69  ? 100 ARG A CB  1 
ATOM   829   C CG  . ARG A 1 100 ? 19.120  6.344   -22.928 1.00 47.72  ? 100 ARG A CG  1 
ATOM   830   C CD  . ARG A 1 100 ? 20.248  6.768   -21.972 1.00 49.07  ? 100 ARG A CD  1 
ATOM   831   N NE  . ARG A 1 100 ? 20.241  6.152   -20.648 1.00 49.24  ? 100 ARG A NE  1 
ATOM   832   C CZ  . ARG A 1 100 ? 20.714  4.942   -20.404 1.00 63.10  ? 100 ARG A CZ  1 
ATOM   833   N NH1 . ARG A 1 100 ? 21.409  4.282   -21.321 1.00 63.61  ? 100 ARG A NH1 1 
ATOM   834   N NH2 . ARG A 1 100 ? 20.525  4.401   -19.214 1.00 59.22  ? 100 ARG A NH2 1 
ATOM   835   N N   . PRO A 1 101 ? 19.318  10.728  -25.302 1.00 32.29  ? 101 PRO A N   1 
ATOM   836   C CA  . PRO A 1 101 ? 20.065  11.546  -26.233 1.00 34.69  ? 101 PRO A CA  1 
ATOM   837   C C   . PRO A 1 101 ? 21.522  11.458  -25.767 1.00 41.92  ? 101 PRO A C   1 
ATOM   838   O O   . PRO A 1 101 ? 21.804  10.821  -24.763 1.00 41.53  ? 101 PRO A O   1 
ATOM   839   C CB  . PRO A 1 101 ? 19.474  12.916  -26.020 1.00 33.99  ? 101 PRO A CB  1 
ATOM   840   C CG  . PRO A 1 101 ? 19.073  12.911  -24.574 1.00 36.41  ? 101 PRO A CG  1 
ATOM   841   C CD  . PRO A 1 101 ? 18.580  11.509  -24.306 1.00 35.42  ? 101 PRO A CD  1 
ATOM   842   N N   . PRO A 1 102 ? 22.514  12.033  -26.484 1.00 39.47  ? 102 PRO A N   1 
ATOM   843   C CA  . PRO A 1 102 ? 23.900  12.021  -26.003 1.00 41.01  ? 102 PRO A CA  1 
ATOM   844   C C   . PRO A 1 102 ? 24.100  12.500  -24.565 1.00 39.03  ? 102 PRO A C   1 
ATOM   845   O O   . PRO A 1 102 ? 24.883  11.918  -23.847 1.00 39.06  ? 102 PRO A O   1 
ATOM   846   C CB  . PRO A 1 102 ? 24.579  12.899  -27.034 1.00 40.24  ? 102 PRO A CB  1 
ATOM   847   C CG  . PRO A 1 102 ? 23.823  12.569  -28.290 1.00 38.41  ? 102 PRO A CG  1 
ATOM   848   C CD  . PRO A 1 102 ? 22.385  12.599  -27.828 1.00 38.39  ? 102 PRO A CD  1 
ATOM   849   N N   . ALA A 1 103 ? 23.321  13.492  -24.136 1.00 42.64  ? 103 ALA A N   1 
ATOM   850   C CA  . ALA A 1 103 ? 23.407  14.045  -22.798 1.00 41.13  ? 103 ALA A CA  1 
ATOM   851   C C   . ALA A 1 103 ? 23.178  12.994  -21.725 1.00 39.61  ? 103 ALA A C   1 
ATOM   852   O O   . ALA A 1 103 ? 23.690  13.139  -20.628 1.00 44.69  ? 103 ALA A O   1 
ATOM   853   C CB  . ALA A 1 103 ? 22.395  15.146  -22.650 1.00 39.85  ? 103 ALA A CB  1 
ATOM   854   N N   . GLY A 1 104 ? 22.341  11.997  -22.011 1.00 39.60  ? 104 GLY A N   1 
ATOM   855   C CA  . GLY A 1 104 ? 22.038  10.957  -21.043 1.00 38.13  ? 104 GLY A CA  1 
ATOM   856   C C   . GLY A 1 104 ? 22.988  9.775   -21.181 1.00 37.17  ? 104 GLY A C   1 
ATOM   857   O O   . GLY A 1 104 ? 23.300  9.098   -20.224 1.00 41.22  ? 104 GLY A O   1 
ATOM   858   N N   . MET A 1 105 ? 23.491  9.544   -22.375 1.00 38.10  ? 105 MET A N   1 
ATOM   859   C CA  . MET A 1 105 ? 24.324  8.385   -22.613 1.00 41.96  ? 105 MET A CA  1 
ATOM   860   C C   . MET A 1 105 ? 25.786  8.624   -22.280 1.00 37.24  ? 105 MET A C   1 
ATOM   861   O O   . MET A 1 105 ? 26.476  7.698   -21.903 1.00 41.60  ? 105 MET A O   1 
ATOM   862   C CB  . MET A 1 105 ? 24.249  8.032   -24.090 1.00 46.52  ? 105 MET A CB  1 
ATOM   863   C CG  . MET A 1 105 ? 22.876  7.558   -24.501 1.00 42.75  ? 105 MET A CG  1 
ATOM   864   S SD  . MET A 1 105 ? 23.048  6.932   -26.175 1.00 43.96  ? 105 MET A SD  1 
ATOM   865   C CE  . MET A 1 105 ? 22.962  8.542   -26.966 1.00 41.96  ? 105 MET A CE  1 
ATOM   866   N N   . HIS A 1 106 ? 26.283  9.843   -22.477 1.00 37.78  ? 106 HIS A N   1 
ATOM   867   C CA  . HIS A 1 106 ? 27.722  10.060  -22.459 1.00 39.31  ? 106 HIS A CA  1 
ATOM   868   C C   . HIS A 1 106 ? 28.246  10.050  -21.030 1.00 41.98  ? 106 HIS A C   1 
ATOM   869   O O   . HIS A 1 106 ? 29.433  9.859   -20.834 1.00 40.96  ? 106 HIS A O   1 
ATOM   870   C CB  . HIS A 1 106 ? 28.108  11.363  -23.168 1.00 41.07  ? 106 HIS A CB  1 
ATOM   871   C CG  . HIS A 1 106 ? 27.953  11.293  -24.647 1.00 37.94  ? 106 HIS A CG  1 
ATOM   872   N ND1 . HIS A 1 106 ? 28.002  12.416  -25.436 1.00 36.37  ? 106 HIS A ND1 1 
ATOM   873   C CD2 . HIS A 1 106 ? 27.809  10.250  -25.478 1.00 35.37  ? 106 HIS A CD2 1 
ATOM   874   C CE1 . HIS A 1 106 ? 27.835  12.051  -26.703 1.00 34.59  ? 106 HIS A CE1 1 
ATOM   875   N NE2 . HIS A 1 106 ? 27.695  10.746  -26.752 1.00 34.81  ? 106 HIS A NE2 1 
ATOM   876   N N   . VAL A 1 107 ? 27.343  10.244  -20.061 1.00 42.75  ? 107 VAL A N   1 
ATOM   877   C CA  . VAL A 1 107 ? 27.693  10.392  -18.667 1.00 38.80  ? 107 VAL A CA  1 
ATOM   878   C C   . VAL A 1 107 ? 28.385  9.121   -18.195 1.00 38.48  ? 107 VAL A C   1 
ATOM   879   O O   . VAL A 1 107 ? 29.091  9.150   -17.197 1.00 40.99  ? 107 VAL A O   1 
ATOM   880   C CB  . VAL A 1 107 ? 26.495  10.701  -17.746 1.00 40.39  ? 107 VAL A CB  1 
ATOM   881   C CG1 . VAL A 1 107 ? 25.839  12.050  -18.029 1.00 34.80  ? 107 VAL A CG1 1 
ATOM   882   C CG2 . VAL A 1 107 ? 25.482  9.562   -17.752 1.00 40.52  ? 107 VAL A CG2 1 
ATOM   883   N N   . VAL A 1 108 ? 28.224  8.023   -18.921 1.00 38.43  ? 108 VAL A N   1 
ATOM   884   C CA  . VAL A 1 108 ? 28.823  6.764   -18.495 1.00 41.15  ? 108 VAL A CA  1 
ATOM   885   C C   . VAL A 1 108 ? 30.357  6.830   -18.587 1.00 44.19  ? 108 VAL A C   1 
ATOM   886   O O   . VAL A 1 108 ? 31.069  6.029   -17.983 1.00 42.84  ? 108 VAL A O   1 
ATOM   887   C CB  . VAL A 1 108 ? 28.204  5.645   -19.361 1.00 42.94  ? 108 VAL A CB  1 
ATOM   888   C CG1 . VAL A 1 108 ? 28.882  5.534   -20.713 1.00 44.89  ? 108 VAL A CG1 1 
ATOM   889   C CG2 . VAL A 1 108 ? 28.239  4.290   -18.689 1.00 51.22  ? 108 VAL A CG2 1 
ATOM   890   N N   . MET A 1 109 ? 30.901  7.753   -19.379 1.00 42.15  ? 109 MET A N   1 
ATOM   891   C CA  . MET A 1 109 ? 32.349  7.788   -19.532 1.00 48.50  ? 109 MET A CA  1 
ATOM   892   C C   . MET A 1 109 ? 32.982  8.609   -18.410 1.00 43.25  ? 109 MET A C   1 
ATOM   893   O O   . MET A 1 109 ? 34.193  8.543   -18.215 1.00 40.62  ? 109 MET A O   1 
ATOM   894   C CB  . MET A 1 109 ? 32.817  8.407   -20.856 1.00 42.47  ? 109 MET A CB  1 
ATOM   895   C CG  . MET A 1 109 ? 32.313  7.707   -22.091 1.00 53.97  ? 109 MET A CG  1 
ATOM   896   S SD  . MET A 1 109 ? 32.804  8.537   -23.617 1.00 53.52  ? 109 MET A SD  1 
ATOM   897   C CE  . MET A 1 109 ? 34.542  8.094   -23.468 1.00 52.47  ? 109 MET A CE  1 
ATOM   898   N N   . TYR A 1 110 ? 32.195  9.444   -17.735 1.00 39.18  ? 110 TYR A N   1 
ATOM   899   C CA  . TYR A 1 110 ? 32.780  10.426  -16.831 1.00 40.48  ? 110 TYR A CA  1 
ATOM   900   C C   . TYR A 1 110 ? 33.687  9.764   -15.789 1.00 41.07  ? 110 TYR A C   1 
ATOM   901   O O   . TYR A 1 110 ? 34.708  10.322  -15.425 1.00 40.73  ? 110 TYR A O   1 
ATOM   902   C CB  . TYR A 1 110 ? 31.688  11.274  -16.183 1.00 43.09  ? 110 TYR A CB  1 
ATOM   903   C CG  . TYR A 1 110 ? 30.861  12.137  -17.132 1.00 41.76  ? 110 TYR A CG  1 
ATOM   904   C CD1 . TYR A 1 110 ? 31.190  12.302  -18.469 1.00 36.90  ? 110 TYR A CD1 1 
ATOM   905   C CD2 . TYR A 1 110 ? 29.780  12.856  -16.651 1.00 41.99  ? 110 TYR A CD2 1 
ATOM   906   C CE1 . TYR A 1 110 ? 30.429  13.100  -19.305 1.00 36.15  ? 110 TYR A CE1 1 
ATOM   907   C CE2 . TYR A 1 110 ? 29.022  13.670  -17.472 1.00 45.37  ? 110 TYR A CE2 1 
ATOM   908   C CZ  . TYR A 1 110 ? 29.333  13.775  -18.812 1.00 39.66  ? 110 TYR A CZ  1 
ATOM   909   O OH  . TYR A 1 110 ? 28.553  14.570  -19.585 1.00 38.84  ? 110 TYR A OH  1 
ATOM   910   N N   . ALA A 1 111 ? 33.375  8.558   -15.326 1.00 43.22  ? 111 ALA A N   1 
ATOM   911   C CA  . ALA A 1 111 ? 34.185  7.996   -14.259 1.00 43.84  ? 111 ALA A CA  1 
ATOM   912   C C   . ALA A 1 111 ? 35.468  7.412   -14.825 1.00 43.64  ? 111 ALA A C   1 
ATOM   913   O O   . ALA A 1 111 ? 36.444  7.269   -14.087 1.00 47.63  ? 111 ALA A O   1 
ATOM   914   C CB  . ALA A 1 111 ? 33.429  6.947   -13.464 1.00 41.97  ? 111 ALA A CB  1 
ATOM   915   N N   . GLN A 1 112 ? 35.451  7.051   -16.111 1.00 44.44  ? 112 GLN A N   1 
ATOM   916   C CA  . GLN A 1 112 ? 36.608  6.410   -16.724 1.00 42.20  ? 112 GLN A CA  1 
ATOM   917   C C   . GLN A 1 112 ? 37.736  7.416   -16.866 1.00 41.33  ? 112 GLN A C   1 
ATOM   918   O O   . GLN A 1 112 ? 38.852  7.150   -16.442 1.00 41.97  ? 112 GLN A O   1 
ATOM   919   C CB  . GLN A 1 112 ? 36.390  5.865   -18.124 1.00 42.80  ? 112 GLN A CB  1 
ATOM   920   C CG  . GLN A 1 112 ? 35.396  4.719   -18.173 1.00 47.24  ? 112 GLN A CG  1 
ATOM   921   C CD  . GLN A 1 112 ? 35.272  4.158   -19.568 1.00 49.63  ? 112 GLN A CD  1 
ATOM   922   O OE1 . GLN A 1 112 ? 35.073  4.898   -20.539 1.00 51.71  ? 112 GLN A OE1 1 
ATOM   923   N NE2 . GLN A 1 112 ? 35.458  2.854   -19.676 1.00 45.02  ? 112 GLN A NE2 1 
ATOM   924   N N   . ILE A 1 113 ? 37.411  8.569   -17.444 1.00 40.01  ? 113 ILE A N   1 
ATOM   925   C CA  . ILE A 1 113 ? 38.394  9.598   -17.716 1.00 41.65  ? 113 ILE A CA  1 
ATOM   926   C C   . ILE A 1 113 ? 38.825  10.261  -16.406 1.00 44.20  ? 113 ILE A C   1 
ATOM   927   O O   . ILE A 1 113 ? 39.935  10.773  -16.322 1.00 54.92  ? 113 ILE A O   1 
ATOM   928   C CB  . ILE A 1 113 ? 37.846  10.586  -18.767 1.00 41.67  ? 113 ILE A CB  1 
ATOM   929   C CG1 . ILE A 1 113 ? 38.870  11.644  -19.200 1.00 48.28  ? 113 ILE A CG1 1 
ATOM   930   C CG2 . ILE A 1 113 ? 36.587  11.272  -18.257 1.00 48.00  ? 113 ILE A CG2 1 
ATOM   931   C CD1 . ILE A 1 113 ? 40.173  11.115  -19.789 1.00 48.86  ? 113 ILE A CD1 1 
ATOM   932   N N   . ASP A 1 114 ? 37.983  10.237  -15.363 1.00 49.18  ? 114 ASP A N   1 
ATOM   933   C CA  . ASP A 1 114 ? 38.364  10.773  -14.053 1.00 44.53  ? 114 ASP A CA  1 
ATOM   934   C C   . ASP A 1 114 ? 39.466  9.938   -13.403 1.00 43.58  ? 114 ASP A C   1 
ATOM   935   O O   . ASP A 1 114 ? 40.309  10.461  -12.693 1.00 43.06  ? 114 ASP A O   1 
ATOM   936   C CB  . ASP A 1 114 ? 37.190  10.784  -13.094 1.00 43.36  ? 114 ASP A CB  1 
ATOM   937   C CG  . ASP A 1 114 ? 37.423  11.410  -11.724 1.00 45.50  ? 114 ASP A CG  1 
ATOM   938   O OD1 . ASP A 1 114 ? 37.791  12.600  -11.672 1.00 47.10  ? 114 ASP A OD1 1 
ATOM   939   O OD2 . ASP A 1 114 ? 37.157  10.729  -10.705 1.00 48.78  ? 114 ASP A OD2 1 
ATOM   940   N N   . ASP A 1 115 ? 39.449  8.626   -13.650 1.00 44.54  ? 115 ASP A N   1 
ATOM   941   C CA  . ASP A 1 115 ? 40.327  7.706   -12.962 1.00 40.82  ? 115 ASP A CA  1 
ATOM   942   C C   . ASP A 1 115 ? 40.698  6.579   -13.915 1.00 41.56  ? 115 ASP A C   1 
ATOM   943   O O   . ASP A 1 115 ? 40.199  5.457   -13.784 1.00 43.93  ? 115 ASP A O   1 
ATOM   944   C CB  . ASP A 1 115 ? 39.664  7.176   -11.702 1.00 45.27  ? 115 ASP A CB  1 
ATOM   945   C CG  . ASP A 1 115 ? 40.525  6.282   -10.822 1.00 47.53  ? 115 ASP A CG  1 
ATOM   946   O OD1 . ASP A 1 115 ? 41.767  6.340   -10.944 1.00 51.04  ? 115 ASP A OD1 1 
ATOM   947   O OD2 . ASP A 1 115 ? 39.944  5.486   -10.071 1.00 54.81  ? 115 ASP A OD2 1 
ATOM   948   N N   . PRO A 1 116 ? 41.531  6.862   -14.940 1.00 37.62  ? 116 PRO A N   1 
ATOM   949   C CA  . PRO A 1 116 ? 41.870  5.851   -15.933 1.00 38.46  ? 116 PRO A CA  1 
ATOM   950   C C   . PRO A 1 116 ? 42.871  4.773   -15.525 1.00 46.43  ? 116 PRO A C   1 
ATOM   951   O O   . PRO A 1 116 ? 42.871  3.671   -16.082 1.00 45.86  ? 116 PRO A O   1 
ATOM   952   C CB  . PRO A 1 116 ? 42.384  6.654   -17.130 1.00 39.34  ? 116 PRO A CB  1 
ATOM   953   C CG  . PRO A 1 116 ? 42.435  8.103   -16.705 1.00 37.15  ? 116 PRO A CG  1 
ATOM   954   C CD  . PRO A 1 116 ? 42.045  8.194   -15.269 1.00 35.60  ? 116 PRO A CD  1 
ATOM   955   N N   . GLU A 1 117 ? 43.769  5.105   -14.594 1.00 50.45  ? 117 GLU A N   1 
ATOM   956   C CA  . GLU A 1 117 ? 44.956  4.287   -14.413 1.00 43.71  ? 117 GLU A CA  1 
ATOM   957   C C   . GLU A 1 117 ? 44.530  2.873   -14.026 1.00 45.90  ? 117 GLU A C   1 
ATOM   958   O O   . GLU A 1 117 ? 45.100  1.898   -14.517 1.00 45.96  ? 117 GLU A O   1 
ATOM   959   C CB  . GLU A 1 117 ? 45.954  4.862   -13.406 1.00 48.15  ? 117 GLU A CB  1 
ATOM   960   C CG  . GLU A 1 117 ? 46.616  6.172   -13.832 1.00 49.21  ? 117 GLU A CG  1 
ATOM   961   C CD  . GLU A 1 117 ? 47.383  6.083   -15.141 1.00 53.13  ? 117 GLU A CD  1 
ATOM   962   O OE1 . GLU A 1 117 ? 48.023  5.041   -15.408 1.00 56.39  ? 117 GLU A OE1 1 
ATOM   963   O OE2 . GLU A 1 117 ? 47.335  7.070   -15.900 1.00 56.03  ? 117 GLU A OE2 1 
ATOM   964   N N   . PRO A 1 118 ? 43.542  2.698   -13.115 1.00 40.50  ? 118 PRO A N   1 
ATOM   965   C CA  . PRO A 1 118 ? 43.174  1.357   -12.679 1.00 37.55  ? 118 PRO A CA  1 
ATOM   966   C C   . PRO A 1 118 ? 42.735  0.480   -13.849 1.00 42.89  ? 118 PRO A C   1 
ATOM   967   O O   . PRO A 1 118 ? 42.932  -0.736  -13.824 1.00 46.91  ? 118 PRO A O   1 
ATOM   968   C CB  . PRO A 1 118 ? 42.073  1.603   -11.638 1.00 38.23  ? 118 PRO A CB  1 
ATOM   969   C CG  . PRO A 1 118 ? 42.290  3.029   -11.190 1.00 39.10  ? 118 PRO A CG  1 
ATOM   970   C CD  . PRO A 1 118 ? 42.831  3.759   -12.393 1.00 39.40  ? 118 PRO A CD  1 
ATOM   971   N N   . TRP A 1 119 ? 42.157  1.108   -14.885 1.00 45.29  ? 119 TRP A N   1 
ATOM   972   C CA  . TRP A 1 119 ? 41.648  0.363   -16.019 1.00 42.10  ? 119 TRP A CA  1 
ATOM   973   C C   . TRP A 1 119 ? 42.791  -0.408  -16.673 1.00 48.21  ? 119 TRP A C   1 
ATOM   974   O O   . TRP A 1 119 ? 42.641  -1.599  -16.994 1.00 49.60  ? 119 TRP A O   1 
ATOM   975   C CB  . TRP A 1 119 ? 40.904  1.302   -16.971 1.00 43.70  ? 119 TRP A CB  1 
ATOM   976   C CG  . TRP A 1 119 ? 39.614  1.824   -16.382 1.00 45.48  ? 119 TRP A CG  1 
ATOM   977   C CD1 . TRP A 1 119 ? 39.442  2.865   -15.515 1.00 48.69  ? 119 TRP A CD1 1 
ATOM   978   C CD2 . TRP A 1 119 ? 38.289  1.293   -16.608 1.00 47.90  ? 119 TRP A CD2 1 
ATOM   979   N NE1 . TRP A 1 119 ? 38.115  3.023   -15.186 1.00 43.02  ? 119 TRP A NE1 1 
ATOM   980   C CE2 . TRP A 1 119 ? 37.389  2.072   -15.843 1.00 46.68  ? 119 TRP A CE2 1 
ATOM   981   C CE3 . TRP A 1 119 ? 37.788  0.239   -17.382 1.00 49.28  ? 119 TRP A CE3 1 
ATOM   982   C CZ2 . TRP A 1 119 ? 36.019  1.835   -15.850 1.00 51.62  ? 119 TRP A CZ2 1 
ATOM   983   C CZ3 . TRP A 1 119 ? 36.435  -0.010  -17.373 1.00 50.98  ? 119 TRP A CZ3 1 
ATOM   984   C CH2 . TRP A 1 119 ? 35.565  0.785   -16.622 1.00 52.33  ? 119 TRP A CH2 1 
ATOM   985   N N   . GLY A 1 120 ? 43.951  0.260   -16.785 1.00 50.85  ? 120 GLY A N   1 
ATOM   986   C CA  . GLY A 1 120 ? 45.191  -0.382  -17.208 1.00 45.34  ? 120 GLY A CA  1 
ATOM   987   C C   . GLY A 1 120 ? 45.796  -1.271  -16.121 1.00 43.95  ? 120 GLY A C   1 
ATOM   988   O O   . GLY A 1 120 ? 46.096  -2.439  -16.352 1.00 43.15  ? 120 GLY A O   1 
ATOM   989   N N   . ASP A 1 121 ? 45.935  -0.725  -14.912 1.00 47.24  ? 121 ASP A N   1 
ATOM   990   C CA  . ASP A 1 121 ? 46.647  -1.423  -13.854 1.00 43.26  ? 121 ASP A CA  1 
ATOM   991   C C   . ASP A 1 121 ? 45.985  -2.775  -13.600 1.00 47.23  ? 121 ASP A C   1 
ATOM   992   O O   . ASP A 1 121 ? 46.679  -3.739  -13.328 1.00 47.98  ? 121 ASP A O   1 
ATOM   993   C CB  . ASP A 1 121 ? 46.730  -0.592  -12.585 1.00 44.48  ? 121 ASP A CB  1 
ATOM   994   C CG  . ASP A 1 121 ? 47.499  0.719   -12.634 1.00 45.62  ? 121 ASP A CG  1 
ATOM   995   O OD1 . ASP A 1 121 ? 48.227  0.965   -13.613 1.00 47.03  ? 121 ASP A OD1 1 
ATOM   996   O OD2 . ASP A 1 121 ? 47.373  1.483   -11.666 1.00 56.04  ? 121 ASP A OD2 1 
ATOM   997   N N   . ASN A 1 122 ? 44.647  -2.864  -13.709 1.00 52.65  ? 122 ASN A N   1 
ATOM   998   C CA  . ASN A 1 122 ? 43.941  -4.088  -13.360 1.00 47.02  ? 122 ASN A CA  1 
ATOM   999   C C   . ASN A 1 122 ? 43.888  -5.069  -14.529 1.00 46.25  ? 122 ASN A C   1 
ATOM   1000  O O   . ASN A 1 122 ? 43.523  -6.225  -14.342 1.00 52.28  ? 122 ASN A O   1 
ATOM   1001  C CB  . ASN A 1 122 ? 42.540  -3.798  -12.841 1.00 50.05  ? 122 ASN A CB  1 
ATOM   1002  C CG  . ASN A 1 122 ? 42.557  -3.046  -11.533 1.00 51.63  ? 122 ASN A CG  1 
ATOM   1003  O OD1 . ASN A 1 122 ? 43.606  -2.887  -10.905 1.00 49.99  ? 122 ASN A OD1 1 
ATOM   1004  N ND2 . ASN A 1 122 ? 41.393  -2.599  -11.089 1.00 51.39  ? 122 ASN A ND2 1 
ATOM   1005  N N   . ALA A 1 123 ? 44.277  -4.639  -15.731 1.00 49.33  ? 123 ALA A N   1 
ATOM   1006  C CA  . ALA A 1 123 ? 44.056  -5.429  -16.933 1.00 49.99  ? 123 ALA A CA  1 
ATOM   1007  C C   . ALA A 1 123 ? 44.836  -6.744  -16.907 1.00 50.88  ? 123 ALA A C   1 
ATOM   1008  O O   . ALA A 1 123 ? 45.858  -6.844  -16.256 1.00 56.23  ? 123 ALA A O   1 
ATOM   1009  C CB  . ALA A 1 123 ? 44.442  -4.590  -18.135 1.00 54.50  ? 123 ALA A CB  1 
ATOM   1010  N N   . VAL A 1 124 ? 44.359  -7.741  -17.659 1.00 50.15  ? 124 VAL A N   1 
ATOM   1011  C CA  . VAL A 1 124 ? 45.036  -9.012  -17.846 1.00 44.18  ? 124 VAL A CA  1 
ATOM   1012  C C   . VAL A 1 124 ? 45.051  -9.307  -19.342 1.00 47.37  ? 124 VAL A C   1 
ATOM   1013  O O   . VAL A 1 124 ? 44.008  -9.567  -19.942 1.00 53.53  ? 124 VAL A O   1 
ATOM   1014  C CB  . VAL A 1 124 ? 44.310  -10.108 -17.047 1.00 49.71  ? 124 VAL A CB  1 
ATOM   1015  C CG1 . VAL A 1 124 ? 44.967  -11.471 -17.194 1.00 53.56  ? 124 VAL A CG1 1 
ATOM   1016  C CG2 . VAL A 1 124 ? 44.215  -9.739  -15.578 1.00 51.92  ? 124 VAL A CG2 1 
ATOM   1017  N N   . VAL A 1 125 ? 46.243  -9.209  -19.935 1.00 44.44  ? 125 VAL A N   1 
ATOM   1018  C CA  . VAL A 1 125 ? 46.463  -9.272  -21.369 1.00 44.68  ? 125 VAL A CA  1 
ATOM   1019  C C   . VAL A 1 125 ? 47.244  -10.543 -21.698 1.00 46.33  ? 125 VAL A C   1 
ATOM   1020  O O   . VAL A 1 125 ? 47.823  -11.168 -20.823 1.00 48.55  ? 125 VAL A O   1 
ATOM   1021  C CB  . VAL A 1 125 ? 47.229  -8.003  -21.763 1.00 42.97  ? 125 VAL A CB  1 
ATOM   1022  C CG1 . VAL A 1 125 ? 47.419  -7.905  -23.258 1.00 43.99  ? 125 VAL A CG1 1 
ATOM   1023  C CG2 . VAL A 1 125 ? 46.530  -6.745  -21.272 1.00 45.91  ? 125 VAL A CG2 1 
ATOM   1024  N N   . ALA A 1 126 ? 47.201  -11.003 -22.942 1.00 51.84  ? 126 ALA A N   1 
ATOM   1025  C CA  . ALA A 1 126 ? 47.836  -12.279 -23.228 1.00 58.17  ? 126 ALA A CA  1 
ATOM   1026  C C   . ALA A 1 126 ? 49.191  -12.052 -23.898 1.00 57.63  ? 126 ALA A C   1 
ATOM   1027  O O   . ALA A 1 126 ? 49.406  -11.033 -24.550 1.00 59.45  ? 126 ALA A O   1 
ATOM   1028  C CB  . ALA A 1 126 ? 46.933  -13.130 -24.079 1.00 54.29  ? 126 ALA A CB  1 
ATOM   1029  N N   . GLY A 1 127 ? 50.100  -13.012 -23.704 1.00 59.46  ? 127 GLY A N   1 
ATOM   1030  C CA  . GLY A 1 127 ? 51.306  -13.126 -24.515 1.00 64.57  ? 127 GLY A CA  1 
ATOM   1031  C C   . GLY A 1 127 ? 52.273  -11.957 -24.319 1.00 60.58  ? 127 GLY A C   1 
ATOM   1032  O O   . GLY A 1 127 ? 52.946  -11.533 -25.248 1.00 65.83  ? 127 GLY A O   1 
ATOM   1033  N N   . GLY A 1 128 ? 52.302  -11.389 -23.117 1.00 59.68  ? 128 GLY A N   1 
ATOM   1034  C CA  . GLY A 1 128 ? 53.271  -10.356 -22.816 1.00 57.35  ? 128 GLY A CA  1 
ATOM   1035  C C   . GLY A 1 128 ? 53.035  -9.048  -23.566 1.00 53.31  ? 128 GLY A C   1 
ATOM   1036  O O   . GLY A 1 128 ? 53.841  -8.138  -23.464 1.00 63.53  ? 128 GLY A O   1 
ATOM   1037  N N   . ARG A 1 129 ? 51.928  -8.887  -24.289 1.00 58.10  ? 129 ARG A N   1 
ATOM   1038  C CA  . ARG A 1 129 ? 51.724  -7.596  -24.924 1.00 54.05  ? 129 ARG A CA  1 
ATOM   1039  C C   . ARG A 1 129 ? 51.477  -6.602  -23.801 1.00 51.74  ? 129 ARG A C   1 
ATOM   1040  O O   . ARG A 1 129 ? 50.955  -6.993  -22.761 1.00 52.65  ? 129 ARG A O   1 
ATOM   1041  C CB  . ARG A 1 129 ? 50.574  -7.593  -25.929 1.00 55.10  ? 129 ARG A CB  1 
ATOM   1042  C CG  . ARG A 1 129 ? 50.610  -8.771  -26.892 1.00 55.50  ? 129 ARG A CG  1 
ATOM   1043  C CD  . ARG A 1 129 ? 49.776  -8.425  -28.102 1.00 57.60  ? 129 ARG A CD  1 
ATOM   1044  N NE  . ARG A 1 129 ? 50.078  -9.268  -29.258 1.00 57.30  ? 129 ARG A NE  1 
ATOM   1045  C CZ  . ARG A 1 129 ? 49.801  -10.550 -29.309 1.00 60.26  ? 129 ARG A CZ  1 
ATOM   1046  N NH1 . ARG A 1 129 ? 49.239  -11.139 -28.273 1.00 57.00  ? 129 ARG A NH1 1 
ATOM   1047  N NH2 . ARG A 1 129 ? 50.095  -11.237 -30.396 1.00 61.33  ? 129 ARG A NH2 1 
ATOM   1048  N N   . THR A 1 130 ? 51.890  -5.346  -23.989 1.00 48.89  ? 130 THR A N   1 
ATOM   1049  C CA  . THR A 1 130 ? 51.583  -4.331  -23.001 1.00 53.07  ? 130 THR A CA  1 
ATOM   1050  C C   . THR A 1 130 ? 50.917  -3.176  -23.725 1.00 53.93  ? 130 THR A C   1 
ATOM   1051  O O   . THR A 1 130 ? 51.468  -2.643  -24.678 1.00 46.13  ? 130 THR A O   1 
ATOM   1052  C CB  . THR A 1 130 ? 52.808  -3.860  -22.215 1.00 63.25  ? 130 THR A CB  1 
ATOM   1053  O OG1 . THR A 1 130 ? 53.813  -3.519  -23.167 1.00 57.72  ? 130 THR A OG1 1 
ATOM   1054  C CG2 . THR A 1 130 ? 53.280  -4.917  -21.231 1.00 65.74  ? 130 THR A CG2 1 
ATOM   1055  N N   . ILE A 1 131 ? 49.741  -2.792  -23.218 1.00 56.04  ? 131 ILE A N   1 
ATOM   1056  C CA  . ILE A 1 131 ? 48.864  -1.861  -23.889 1.00 49.99  ? 131 ILE A CA  1 
ATOM   1057  C C   . ILE A 1 131 ? 48.688  -0.688  -22.947 1.00 44.05  ? 131 ILE A C   1 
ATOM   1058  O O   . ILE A 1 131 ? 48.568  -0.903  -21.755 1.00 40.55  ? 131 ILE A O   1 
ATOM   1059  C CB  . ILE A 1 131 ? 47.549  -2.582  -24.224 1.00 57.99  ? 131 ILE A CB  1 
ATOM   1060  C CG1 . ILE A 1 131 ? 47.806  -3.901  -24.940 1.00 59.86  ? 131 ILE A CG1 1 
ATOM   1061  C CG2 . ILE A 1 131 ? 46.616  -1.688  -25.029 1.00 59.74  ? 131 ILE A CG2 1 
ATOM   1062  C CD1 . ILE A 1 131 ? 48.537  -3.745  -26.260 1.00 57.57  ? 131 ILE A CD1 1 
ATOM   1063  N N   . SER A 1 132 ? 48.678  0.537   -23.470 1.00 46.43  ? 132 SER A N   1 
ATOM   1064  C CA  . SER A 1 132 ? 48.533  1.698   -22.612 1.00 49.35  ? 132 SER A CA  1 
ATOM   1065  C C   . SER A 1 132 ? 47.060  2.090   -22.466 1.00 46.91  ? 132 SER A C   1 
ATOM   1066  O O   . SER A 1 132 ? 46.612  3.150   -22.917 1.00 45.91  ? 132 SER A O   1 
ATOM   1067  C CB  . SER A 1 132 ? 49.361  2.814   -23.129 1.00 55.47  ? 132 SER A CB  1 
ATOM   1068  O OG  . SER A 1 132 ? 50.728  2.540   -22.869 1.00 69.25  ? 132 SER A OG  1 
ATOM   1069  N N   . PHE A 1 133 ? 46.321  1.248   -21.750 1.00 42.83  ? 133 PHE A N   1 
ATOM   1070  C CA  . PHE A 1 133 ? 44.890  1.453   -21.565 1.00 45.93  ? 133 PHE A CA  1 
ATOM   1071  C C   . PHE A 1 133 ? 44.584  2.854   -21.059 1.00 37.79  ? 133 PHE A C   1 
ATOM   1072  O O   . PHE A 1 133 ? 43.710  3.536   -21.590 1.00 40.77  ? 133 PHE A O   1 
ATOM   1073  C CB  . PHE A 1 133 ? 44.359  0.393   -20.613 1.00 43.85  ? 133 PHE A CB  1 
ATOM   1074  C CG  . PHE A 1 133 ? 44.452  -1.002  -21.200 1.00 42.83  ? 133 PHE A CG  1 
ATOM   1075  C CD1 . PHE A 1 133 ? 43.698  -1.353  -22.311 1.00 46.99  ? 133 PHE A CD1 1 
ATOM   1076  C CD2 . PHE A 1 133 ? 45.234  -1.976  -20.602 1.00 44.74  ? 133 PHE A CD2 1 
ATOM   1077  C CE1 . PHE A 1 133 ? 43.763  -2.645  -22.826 1.00 47.01  ? 133 PHE A CE1 1 
ATOM   1078  C CE2 . PHE A 1 133 ? 45.283  -3.268  -21.111 1.00 43.45  ? 133 PHE A CE2 1 
ATOM   1079  C CZ  . PHE A 1 133 ? 44.563  -3.591  -22.232 1.00 47.22  ? 133 PHE A CZ  1 
ATOM   1080  N N   . ALA A 1 134 ? 45.303  3.298   -20.045 1.00 37.79  ? 134 ALA A N   1 
ATOM   1081  C CA  . ALA A 1 134 ? 45.007  4.611   -19.496 1.00 41.26  ? 134 ALA A CA  1 
ATOM   1082  C C   . ALA A 1 134 ? 45.192  5.688   -20.556 1.00 43.90  ? 134 ALA A C   1 
ATOM   1083  O O   . ALA A 1 134 ? 44.323  6.552   -20.716 1.00 49.52  ? 134 ALA A O   1 
ATOM   1084  C CB  . ALA A 1 134 ? 45.821  4.868   -18.266 1.00 39.82  ? 134 ALA A CB  1 
ATOM   1085  N N   . ASP A 1 135 ? 46.278  5.583   -21.332 1.00 50.20  ? 135 ASP A N   1 
ATOM   1086  C CA  . ASP A 1 135 ? 46.510  6.494   -22.449 1.00 48.28  ? 135 ASP A CA  1 
ATOM   1087  C C   . ASP A 1 135 ? 45.360  6.402   -23.455 1.00 44.03  ? 135 ASP A C   1 
ATOM   1088  O O   . ASP A 1 135 ? 44.887  7.406   -23.983 1.00 44.25  ? 135 ASP A O   1 
ATOM   1089  C CB  . ASP A 1 135 ? 47.817  6.196   -23.164 1.00 48.51  ? 135 ASP A CB  1 
ATOM   1090  C CG  . ASP A 1 135 ? 49.106  6.530   -22.422 1.00 54.91  ? 135 ASP A CG  1 
ATOM   1091  O OD1 . ASP A 1 135 ? 49.052  7.294   -21.440 1.00 52.47  ? 135 ASP A OD1 1 
ATOM   1092  O OD2 . ASP A 1 135 ? 50.158  6.005   -22.838 1.00 64.53  ? 135 ASP A OD2 1 
ATOM   1093  N N   . ASN A 1 136 ? 44.940  5.177   -23.751 1.00 39.12  ? 136 ASN A N   1 
ATOM   1094  C CA  . ASN A 1 136 ? 43.812  4.947   -24.634 1.00 41.69  ? 136 ASN A CA  1 
ATOM   1095  C C   . ASN A 1 136 ? 42.587  5.737   -24.184 1.00 40.82  ? 136 ASN A C   1 
ATOM   1096  O O   . ASN A 1 136 ? 41.950  6.379   -25.007 1.00 44.85  ? 136 ASN A O   1 
ATOM   1097  C CB  . ASN A 1 136 ? 43.472  3.464   -24.717 1.00 38.36  ? 136 ASN A CB  1 
ATOM   1098  C CG  . ASN A 1 136 ? 44.494  2.701   -25.514 1.00 37.48  ? 136 ASN A CG  1 
ATOM   1099  O OD1 . ASN A 1 136 ? 45.346  3.316   -26.148 1.00 40.73  ? 136 ASN A OD1 1 
ATOM   1100  N ND2 . ASN A 1 136 ? 44.444  1.375   -25.493 1.00 43.96  ? 136 ASN A ND2 1 
ATOM   1101  N N   . ILE A 1 137 ? 42.278  5.705   -22.883 1.00 41.65  ? 137 ILE A N   1 
ATOM   1102  C CA  . ILE A 1 137 ? 41.118  6.402   -22.350 1.00 38.67  ? 137 ILE A CA  1 
ATOM   1103  C C   . ILE A 1 137 ? 41.286  7.904   -22.564 1.00 40.60  ? 137 ILE A C   1 
ATOM   1104  O O   . ILE A 1 137 ? 40.366  8.598   -23.014 1.00 46.33  ? 137 ILE A O   1 
ATOM   1105  C CB  . ILE A 1 137 ? 40.908  6.008   -20.875 1.00 39.86  ? 137 ILE A CB  1 
ATOM   1106  C CG1 . ILE A 1 137 ? 40.469  4.556   -20.784 1.00 34.79  ? 137 ILE A CG1 1 
ATOM   1107  C CG2 . ILE A 1 137 ? 39.934  6.940   -20.149 1.00 38.90  ? 137 ILE A CG2 1 
ATOM   1108  C CD1 . ILE A 1 137 ? 40.440  4.013   -19.372 1.00 36.50  ? 137 ILE A CD1 1 
ATOM   1109  N N   . ARG A 1 138 ? 42.489  8.411   -22.319 1.00 41.00  ? 138 ARG A N   1 
ATOM   1110  C CA  . ARG A 1 138 ? 42.685  9.851   -22.406 1.00 40.97  ? 138 ARG A CA  1 
ATOM   1111  C C   . ARG A 1 138 ? 42.510  10.299  -23.849 1.00 41.54  ? 138 ARG A C   1 
ATOM   1112  O O   . ARG A 1 138 ? 41.930  11.349  -24.108 1.00 42.09  ? 138 ARG A O   1 
ATOM   1113  C CB  . ARG A 1 138 ? 44.011  10.307  -21.793 1.00 43.36  ? 138 ARG A CB  1 
ATOM   1114  C CG  . ARG A 1 138 ? 43.864  10.443  -20.287 1.00 43.96  ? 138 ARG A CG  1 
ATOM   1115  C CD  . ARG A 1 138 ? 45.099  10.858  -19.511 1.00 48.64  ? 138 ARG A CD  1 
ATOM   1116  N NE  . ARG A 1 138 ? 46.135  9.830   -19.585 1.00 51.10  ? 138 ARG A NE  1 
ATOM   1117  C CZ  . ARG A 1 138 ? 46.483  8.969   -18.632 1.00 53.44  ? 138 ARG A CZ  1 
ATOM   1118  N NH1 . ARG A 1 138 ? 45.944  8.996   -17.431 1.00 53.55  ? 138 ARG A NH1 1 
ATOM   1119  N NH2 . ARG A 1 138 ? 47.354  8.027   -18.921 1.00 58.00  ? 138 ARG A NH2 1 
ATOM   1120  N N   . SER A 1 139 ? 42.994  9.503   -24.798 1.00 41.37  ? 139 SER A N   1 
ATOM   1121  C CA  . SER A 1 139 ? 42.956  9.953   -26.180 1.00 44.33  ? 139 SER A CA  1 
ATOM   1122  C C   . SER A 1 139 ? 41.579  9.685   -26.785 1.00 43.47  ? 139 SER A C   1 
ATOM   1123  O O   . SER A 1 139 ? 41.079  10.509  -27.555 1.00 44.18  ? 139 SER A O   1 
ATOM   1124  C CB  . SER A 1 139 ? 44.084  9.378   -26.999 1.00 47.92  ? 139 SER A CB  1 
ATOM   1125  O OG  . SER A 1 139 ? 44.030  7.964   -27.051 1.00 53.61  ? 139 SER A OG  1 
ATOM   1126  N N   . GLN A 1 140 ? 40.948  8.564   -26.400 1.00 41.67  ? 140 GLN A N   1 
ATOM   1127  C CA  . GLN A 1 140 ? 39.523  8.373   -26.658 1.00 41.68  ? 140 GLN A CA  1 
ATOM   1128  C C   . GLN A 1 140 ? 38.755  9.637   -26.264 1.00 37.99  ? 140 GLN A C   1 
ATOM   1129  O O   . GLN A 1 140 ? 38.081  10.251  -27.095 1.00 38.84  ? 140 GLN A O   1 
ATOM   1130  C CB  . GLN A 1 140 ? 39.031  7.088   -25.999 1.00 43.40  ? 140 GLN A CB  1 
ATOM   1131  C CG  . GLN A 1 140 ? 39.584  5.813   -26.636 1.00 42.86  ? 140 GLN A CG  1 
ATOM   1132  C CD  . GLN A 1 140 ? 39.292  4.582   -25.805 1.00 48.45  ? 140 GLN A CD  1 
ATOM   1133  O OE1 . GLN A 1 140 ? 38.415  4.600   -24.937 1.00 54.43  ? 140 GLN A OE1 1 
ATOM   1134  N NE2 . GLN A 1 140 ? 39.980  3.482   -26.075 1.00 49.84  ? 140 GLN A NE2 1 
ATOM   1135  N N   . TRP A 1 141 ? 38.951  10.109  -25.034 1.00 40.67  ? 141 TRP A N   1 
ATOM   1136  C CA  . TRP A 1 141 ? 38.216  11.280  -24.563 1.00 40.37  ? 141 TRP A CA  1 
ATOM   1137  C C   . TRP A 1 141 ? 38.509  12.505  -25.427 1.00 45.25  ? 141 TRP A C   1 
ATOM   1138  O O   . TRP A 1 141 ? 37.614  13.300  -25.721 1.00 43.96  ? 141 TRP A O   1 
ATOM   1139  C CB  . TRP A 1 141 ? 38.566  11.525  -23.089 1.00 37.79  ? 141 TRP A CB  1 
ATOM   1140  C CG  . TRP A 1 141 ? 37.778  12.620  -22.443 1.00 37.38  ? 141 TRP A CG  1 
ATOM   1141  C CD1 . TRP A 1 141 ? 38.245  13.855  -22.103 1.00 40.69  ? 141 TRP A CD1 1 
ATOM   1142  C CD2 . TRP A 1 141 ? 36.380  12.614  -22.097 1.00 38.37  ? 141 TRP A CD2 1 
ATOM   1143  N NE1 . TRP A 1 141 ? 37.244  14.604  -21.549 1.00 38.78  ? 141 TRP A NE1 1 
ATOM   1144  C CE2 . TRP A 1 141 ? 36.089  13.882  -21.547 1.00 38.61  ? 141 TRP A CE2 1 
ATOM   1145  C CE3 . TRP A 1 141 ? 35.347  11.684  -22.220 1.00 38.97  ? 141 TRP A CE3 1 
ATOM   1146  C CZ2 . TRP A 1 141 ? 34.820  14.240  -21.117 1.00 40.61  ? 141 TRP A CZ2 1 
ATOM   1147  C CZ3 . TRP A 1 141 ? 34.087  12.048  -21.806 1.00 38.22  ? 141 TRP A CZ3 1 
ATOM   1148  C CH2 . TRP A 1 141 ? 33.829  13.299  -21.260 1.00 36.69  ? 141 TRP A CH2 1 
ATOM   1149  N N   . GLN A 1 142 ? 39.780  12.664  -25.828 1.00 49.19  ? 142 GLN A N   1 
ATOM   1150  C CA  . GLN A 1 142 ? 40.187  13.824  -26.610 1.00 47.20  ? 142 GLN A CA  1 
ATOM   1151  C C   . GLN A 1 142 ? 39.543  13.762  -27.993 1.00 36.45  ? 142 GLN A C   1 
ATOM   1152  O O   . GLN A 1 142 ? 39.134  14.774  -28.525 1.00 36.44  ? 142 GLN A O   1 
ATOM   1153  C CB  . GLN A 1 142 ? 41.714  13.958  -26.678 1.00 56.82  ? 142 GLN A CB  1 
ATOM   1154  C CG  . GLN A 1 142 ? 42.217  15.211  -27.401 1.00 62.94  ? 142 GLN A CG  1 
ATOM   1155  C CD  . GLN A 1 142 ? 42.154  15.144  -28.920 1.00 65.62  ? 142 GLN A CD  1 
ATOM   1156  O OE1 . GLN A 1 142 ? 42.165  14.068  -29.549 1.00 55.42  ? 142 GLN A OE1 1 
ATOM   1157  N NE2 . GLN A 1 142 ? 42.106  16.322  -29.535 1.00 59.76  ? 142 GLN A NE2 1 
ATOM   1158  N N   . ARG A 1 143 ? 39.421  12.577  -28.575 1.00 36.46  ? 143 ARG A N   1 
ATOM   1159  C CA  . ARG A 1 143 ? 38.821  12.465  -29.896 1.00 38.68  ? 143 ARG A CA  1 
ATOM   1160  C C   . ARG A 1 143 ? 37.304  12.661  -29.835 1.00 39.29  ? 143 ARG A C   1 
ATOM   1161  O O   . ARG A 1 143 ? 36.721  13.374  -30.651 1.00 40.45  ? 143 ARG A O   1 
ATOM   1162  C CB  . ARG A 1 143 ? 39.155  11.098  -30.500 1.00 39.84  ? 143 ARG A CB  1 
ATOM   1163  C CG  . ARG A 1 143 ? 38.631  10.829  -31.904 1.00 38.29  ? 143 ARG A CG  1 
ATOM   1164  C CD  . ARG A 1 143 ? 39.017  9.438   -32.405 1.00 38.20  ? 143 ARG A CD  1 
ATOM   1165  N NE  . ARG A 1 143 ? 38.501  8.338   -31.578 1.00 43.29  ? 143 ARG A NE  1 
ATOM   1166  C CZ  . ARG A 1 143 ? 37.219  7.976   -31.604 1.00 46.12  ? 143 ARG A CZ  1 
ATOM   1167  N NH1 . ARG A 1 143 ? 36.363  8.650   -32.348 1.00 39.59  ? 143 ARG A NH1 1 
ATOM   1168  N NH2 . ARG A 1 143 ? 36.804  6.928   -30.929 1.00 44.03  ? 143 ARG A NH2 1 
ATOM   1169  N N   . VAL A 1 144 ? 36.628  12.007  -28.897 1.00 36.53  ? 144 VAL A N   1 
ATOM   1170  C CA  . VAL A 1 144 ? 35.177  12.048  -28.961 1.00 35.64  ? 144 VAL A CA  1 
ATOM   1171  C C   . VAL A 1 144 ? 34.676  13.435  -28.579 1.00 35.34  ? 144 VAL A C   1 
ATOM   1172  O O   . VAL A 1 144 ? 33.629  13.825  -29.088 1.00 35.99  ? 144 VAL A O   1 
ATOM   1173  C CB  . VAL A 1 144 ? 34.476  10.957  -28.142 1.00 39.79  ? 144 VAL A CB  1 
ATOM   1174  C CG1 . VAL A 1 144 ? 34.950  9.565   -28.552 1.00 37.15  ? 144 VAL A CG1 1 
ATOM   1175  C CG2 . VAL A 1 144 ? 34.653  11.171  -26.648 1.00 41.27  ? 144 VAL A CG2 1 
ATOM   1176  N N   . THR A 1 145 ? 35.433  14.196  -27.768 1.00 37.91  ? 145 THR A N   1 
ATOM   1177  C CA  . THR A 1 145 ? 34.986  15.517  -27.319 1.00 40.39  ? 145 THR A CA  1 
ATOM   1178  C C   . THR A 1 145 ? 35.236  16.558  -28.400 1.00 42.97  ? 145 THR A C   1 
ATOM   1179  O O   . THR A 1 145 ? 34.477  17.497  -28.556 1.00 47.71  ? 145 THR A O   1 
ATOM   1180  C CB  . THR A 1 145 ? 35.676  15.946  -26.020 1.00 42.99  ? 145 THR A CB  1 
ATOM   1181  O OG1 . THR A 1 145 ? 37.071  15.747  -26.171 1.00 41.19  ? 145 THR A OG1 1 
ATOM   1182  C CG2 . THR A 1 145 ? 35.269  15.110  -24.821 1.00 46.96  ? 145 THR A CG2 1 
ATOM   1183  N N   . THR A 1 146 ? 36.326  16.382  -29.130 1.00 48.04  ? 146 THR A N   1 
ATOM   1184  C CA  . THR A 1 146 ? 36.745  17.296  -30.180 1.00 43.52  ? 146 THR A CA  1 
ATOM   1185  C C   . THR A 1 146 ? 35.852  17.101  -31.384 1.00 34.99  ? 146 THR A C   1 
ATOM   1186  O O   . THR A 1 146 ? 35.503  18.078  -32.002 1.00 40.14  ? 146 THR A O   1 
ATOM   1187  C CB  . THR A 1 146 ? 38.213  17.025  -30.574 1.00 44.26  ? 146 THR A CB  1 
ATOM   1188  O OG1 . THR A 1 146 ? 39.031  17.504  -29.521 1.00 38.47  ? 146 THR A OG1 1 
ATOM   1189  C CG2 . THR A 1 146 ? 38.670  17.770  -31.816 1.00 40.69  ? 146 THR A CG2 1 
ATOM   1190  N N   . ASP A 1 147 ? 35.642  15.847  -31.803 1.00 35.91  ? 147 ASP A N   1 
ATOM   1191  C CA  . ASP A 1 147 ? 34.850  15.538  -32.986 1.00 35.64  ? 147 ASP A CA  1 
ATOM   1192  C C   . ASP A 1 147 ? 33.348  15.474  -32.688 1.00 38.36  ? 147 ASP A C   1 
ATOM   1193  O O   . ASP A 1 147 ? 32.565  15.281  -33.607 1.00 43.76  ? 147 ASP A O   1 
ATOM   1194  C CB  . ASP A 1 147 ? 35.269  14.203  -33.572 1.00 39.26  ? 147 ASP A CB  1 
ATOM   1195  C CG  . ASP A 1 147 ? 36.665  14.171  -34.183 1.00 40.45  ? 147 ASP A CG  1 
ATOM   1196  O OD1 . ASP A 1 147 ? 37.237  15.252  -34.298 1.00 40.12  ? 147 ASP A OD1 1 
ATOM   1197  O OD2 . ASP A 1 147 ? 37.169  13.066  -34.505 1.00 38.82  ? 147 ASP A OD2 1 
ATOM   1198  N N   . ASP A 1 148 ? 32.953  15.558  -31.403 1.00 40.27  ? 148 ASP A N   1 
ATOM   1199  C CA  . ASP A 1 148 ? 31.564  15.468  -30.957 1.00 37.79  ? 148 ASP A CA  1 
ATOM   1200  C C   . ASP A 1 148 ? 30.884  14.179  -31.413 1.00 34.01  ? 148 ASP A C   1 
ATOM   1201  O O   . ASP A 1 148 ? 29.829  14.220  -32.032 1.00 33.43  ? 148 ASP A O   1 
ATOM   1202  C CB  . ASP A 1 148 ? 30.779  16.658  -31.457 1.00 37.29  ? 148 ASP A CB  1 
ATOM   1203  C CG  . ASP A 1 148 ? 29.599  17.068  -30.611 1.00 38.89  ? 148 ASP A CG  1 
ATOM   1204  O OD1 . ASP A 1 148 ? 29.400  16.461  -29.559 1.00 41.53  ? 148 ASP A OD1 1 
ATOM   1205  O OD2 . ASP A 1 148 ? 28.915  18.013  -31.028 1.00 42.55  ? 148 ASP A OD2 1 
ATOM   1206  N N   . VAL A 1 149 ? 31.513  13.032  -31.147 1.00 32.35  ? 149 VAL A N   1 
ATOM   1207  C CA  . VAL A 1 149 ? 30.927  11.758  -31.520 1.00 32.93  ? 149 VAL A CA  1 
ATOM   1208  C C   . VAL A 1 149 ? 29.750  11.411  -30.612 1.00 37.19  ? 149 VAL A C   1 
ATOM   1209  O O   . VAL A 1 149 ? 29.727  11.798  -29.449 1.00 40.43  ? 149 VAL A O   1 
ATOM   1210  C CB  . VAL A 1 149 ? 31.971  10.651  -31.407 1.00 32.53  ? 149 VAL A CB  1 
ATOM   1211  C CG1 . VAL A 1 149 ? 31.366  9.313   -31.739 1.00 35.38  ? 149 VAL A CG1 1 
ATOM   1212  C CG2 . VAL A 1 149 ? 33.158  10.900  -32.316 1.00 35.37  ? 149 VAL A CG2 1 
ATOM   1213  N N   . ALA A 1 150 ? 28.821  10.603  -31.129 1.00 35.23  ? 150 ALA A N   1 
ATOM   1214  C CA  . ALA A 1 150 ? 27.711  10.128  -30.331 1.00 37.29  ? 150 ALA A CA  1 
ATOM   1215  C C   . ALA A 1 150 ? 27.982  8.677   -29.964 1.00 34.70  ? 150 ALA A C   1 
ATOM   1216  O O   . ALA A 1 150 ? 28.349  7.883   -30.813 1.00 33.95  ? 150 ALA A O   1 
ATOM   1217  C CB  . ALA A 1 150 ? 26.401  10.330  -31.067 1.00 34.64  ? 150 ALA A CB  1 
ATOM   1218  N N   . LEU A 1 151 ? 27.828  8.372   -28.678 1.00 32.85  ? 151 LEU A N   1 
ATOM   1219  C CA  . LEU A 1 151 ? 28.222  7.093   -28.117 1.00 33.35  ? 151 LEU A CA  1 
ATOM   1220  C C   . LEU A 1 151 ? 27.067  6.525   -27.299 1.00 33.42  ? 151 LEU A C   1 
ATOM   1221  O O   . LEU A 1 151 ? 26.344  7.279   -26.653 1.00 27.84  ? 151 LEU A O   1 
ATOM   1222  C CB  . LEU A 1 151 ? 29.417  7.414   -27.233 1.00 39.57  ? 151 LEU A CB  1 
ATOM   1223  C CG  . LEU A 1 151 ? 30.698  7.807   -27.987 1.00 41.48  ? 151 LEU A CG  1 
ATOM   1224  C CD1 . LEU A 1 151 ? 31.412  8.990   -27.438 1.00 43.53  ? 151 LEU A CD1 1 
ATOM   1225  C CD2 . LEU A 1 151 ? 31.647  6.639   -27.948 1.00 42.99  ? 151 LEU A CD2 1 
ATOM   1226  N N   . SER A 1 152 ? 26.879  5.205   -27.364 1.00 27.25  ? 152 SER A N   1 
ATOM   1227  C CA  . SER A 1 152 ? 25.901  4.619   -26.500 1.00 33.58  ? 152 SER A CA  1 
ATOM   1228  C C   . SER A 1 152 ? 26.489  3.394   -25.844 1.00 33.64  ? 152 SER A C   1 
ATOM   1229  O O   . SER A 1 152 ? 27.122  2.599   -26.502 1.00 33.84  ? 152 SER A O   1 
ATOM   1230  C CB  . SER A 1 152 ? 24.668  4.301   -27.272 1.00 37.48  ? 152 SER A CB  1 
ATOM   1231  O OG  . SER A 1 152 ? 23.953  3.261   -26.646 1.00 30.25  ? 152 SER A OG  1 
ATOM   1232  N N   . PRO A 1 153 ? 26.253  3.208   -24.538 1.00 32.60  ? 153 PRO A N   1 
ATOM   1233  C CA  . PRO A 1 153 ? 26.770  2.058   -23.824 1.00 33.60  ? 153 PRO A CA  1 
ATOM   1234  C C   . PRO A 1 153 ? 25.996  0.778   -24.056 1.00 34.03  ? 153 PRO A C   1 
ATOM   1235  O O   . PRO A 1 153 ? 24.784  0.790   -24.129 1.00 39.23  ? 153 PRO A O   1 
ATOM   1236  C CB  . PRO A 1 153 ? 26.634  2.537   -22.370 1.00 34.53  ? 153 PRO A CB  1 
ATOM   1237  C CG  . PRO A 1 153 ? 25.401  3.371   -22.365 1.00 31.19  ? 153 PRO A CG  1 
ATOM   1238  C CD  . PRO A 1 153 ? 25.491  4.118   -23.675 1.00 33.10  ? 153 PRO A CD  1 
ATOM   1239  N N   . MET A 1 154 ? 26.714  -0.332  -24.114 1.00 33.10  ? 154 MET A N   1 
ATOM   1240  C CA  . MET A 1 154 ? 26.101  -1.637  -24.061 1.00 32.50  ? 154 MET A CA  1 
ATOM   1241  C C   . MET A 1 154 ? 26.875  -2.421  -23.013 1.00 37.22  ? 154 MET A C   1 
ATOM   1242  O O   . MET A 1 154 ? 28.012  -2.803  -23.283 1.00 38.89  ? 154 MET A O   1 
ATOM   1243  C CB  . MET A 1 154 ? 26.207  -2.362  -25.404 1.00 35.30  ? 154 MET A CB  1 
ATOM   1244  C CG  . MET A 1 154 ? 25.502  -1.705  -26.595 1.00 36.96  ? 154 MET A CG  1 
ATOM   1245  S SD  . MET A 1 154 ? 25.113  -2.851  -27.933 1.00 36.23  ? 154 MET A SD  1 
ATOM   1246  C CE  . MET A 1 154 ? 23.753  -3.722  -27.155 1.00 38.82  ? 154 MET A CE  1 
ATOM   1247  N N   . PHE A 1 155 ? 26.293  -2.598  -21.817 1.00 38.41  ? 155 PHE A N   1 
ATOM   1248  C CA  . PHE A 1 155 ? 26.981  -3.265  -20.718 1.00 40.32  ? 155 PHE A CA  1 
ATOM   1249  C C   . PHE A 1 155 ? 26.285  -4.562  -20.290 1.00 38.05  ? 155 PHE A C   1 
ATOM   1250  O O   . PHE A 1 155 ? 26.906  -5.448  -19.708 1.00 52.73  ? 155 PHE A O   1 
ATOM   1251  C CB  . PHE A 1 155 ? 27.098  -2.277  -19.552 1.00 37.61  ? 155 PHE A CB  1 
ATOM   1252  C CG  . PHE A 1 155 ? 28.305  -1.353  -19.539 1.00 35.91  ? 155 PHE A CG  1 
ATOM   1253  C CD1 . PHE A 1 155 ? 28.603  -0.534  -20.612 1.00 40.63  ? 155 PHE A CD1 1 
ATOM   1254  C CD2 . PHE A 1 155 ? 29.145  -1.308  -18.433 1.00 40.06  ? 155 PHE A CD2 1 
ATOM   1255  C CE1 . PHE A 1 155 ? 29.725  0.295   -20.584 1.00 42.17  ? 155 PHE A CE1 1 
ATOM   1256  C CE2 . PHE A 1 155 ? 30.257  -0.477  -18.401 1.00 42.53  ? 155 PHE A CE2 1 
ATOM   1257  C CZ  . PHE A 1 155 ? 30.551  0.323   -19.480 1.00 42.53  ? 155 PHE A CZ  1 
ATOM   1258  N N   . VAL A 1 156 ? 24.994  -4.692  -20.551 1.00 34.37  ? 156 VAL A N   1 
ATOM   1259  C CA  . VAL A 1 156 ? 24.233  -5.840  -20.089 1.00 36.18  ? 156 VAL A CA  1 
ATOM   1260  C C   . VAL A 1 156 ? 24.492  -7.080  -20.946 1.00 35.60  ? 156 VAL A C   1 
ATOM   1261  O O   . VAL A 1 156 ? 24.492  -7.019  -22.181 1.00 39.31  ? 156 VAL A O   1 
ATOM   1262  C CB  . VAL A 1 156 ? 22.753  -5.420  -20.107 1.00 42.31  ? 156 VAL A CB  1 
ATOM   1263  C CG1 . VAL A 1 156 ? 21.821  -6.585  -19.845 1.00 45.20  ? 156 VAL A CG1 1 
ATOM   1264  C CG2 . VAL A 1 156 ? 22.495  -4.336  -19.083 1.00 42.42  ? 156 VAL A CG2 1 
ATOM   1265  N N   . ASP A 1 157 ? 24.586  -8.232  -20.268 1.00 37.76  ? 157 ASP A N   1 
ATOM   1266  C CA  . ASP A 1 157 ? 24.905  -9.511  -20.889 1.00 40.17  ? 157 ASP A CA  1 
ATOM   1267  C C   . ASP A 1 157 ? 23.723  -10.474 -20.839 1.00 42.99  ? 157 ASP A C   1 
ATOM   1268  O O   . ASP A 1 157 ? 22.913  -10.437 -19.924 1.00 49.51  ? 157 ASP A O   1 
ATOM   1269  C CB  . ASP A 1 157 ? 26.135  -10.141 -20.256 1.00 40.03  ? 157 ASP A CB  1 
ATOM   1270  C CG  . ASP A 1 157 ? 27.417  -9.373  -20.525 1.00 45.86  ? 157 ASP A CG  1 
ATOM   1271  O OD1 . ASP A 1 157 ? 27.798  -9.238  -21.703 1.00 48.85  ? 157 ASP A OD1 1 
ATOM   1272  O OD2 . ASP A 1 157 ? 27.986  -8.850  -19.573 1.00 52.11  ? 157 ASP A OD2 1 
ATOM   1273  N N   . VAL A 1 158 ? 23.679  -11.372 -21.821 1.00 46.60  ? 158 VAL A N   1 
ATOM   1274  C CA  . VAL A 1 158 ? 22.672  -12.416 -21.902 1.00 59.82  ? 158 VAL A CA  1 
ATOM   1275  C C   . VAL A 1 158 ? 22.889  -13.379 -20.744 1.00 63.78  ? 158 VAL A C   1 
ATOM   1276  O O   . VAL A 1 158 ? 24.030  -13.608 -20.366 1.00 63.10  ? 158 VAL A O   1 
ATOM   1277  C CB  . VAL A 1 158 ? 22.672  -13.158 -23.256 1.00 51.78  ? 158 VAL A CB  1 
ATOM   1278  C CG1 . VAL A 1 158 ? 22.280  -12.231 -24.397 1.00 55.53  ? 158 VAL A CG1 1 
ATOM   1279  C CG2 . VAL A 1 158 ? 24.004  -13.803 -23.565 1.00 52.07  ? 158 VAL A CG2 1 
ATOM   1280  N N   . GLN A 1 159 ? 21.787  -13.949 -20.228 1.00 85.41  ? 159 GLN A N   1 
ATOM   1281  C CA  . GLN A 1 159 ? 21.783  -14.608 -18.925 1.00 105.77 ? 159 GLN A CA  1 
ATOM   1282  C C   . GLN A 1 159 ? 22.766  -15.787 -18.924 1.00 110.49 ? 159 GLN A C   1 
ATOM   1283  O O   . GLN A 1 159 ? 23.823  -15.713 -18.300 1.00 118.83 ? 159 GLN A O   1 
ATOM   1284  C CB  . GLN A 1 159 ? 20.371  -14.905 -18.384 1.00 106.62 ? 159 GLN A CB  1 
ATOM   1285  C CG  . GLN A 1 159 ? 19.462  -15.777 -19.254 1.00 111.27 ? 159 GLN A CG  1 
ATOM   1286  C CD  . GLN A 1 159 ? 18.491  -16.639 -18.461 1.00 116.73 ? 159 GLN A CD  1 
ATOM   1287  O OE1 . GLN A 1 159 ? 17.756  -16.148 -17.592 1.00 107.10 ? 159 GLN A OE1 1 
ATOM   1288  N NE2 . GLN A 1 159 ? 18.474  -17.940 -18.744 1.00 99.14  ? 159 GLN A NE2 1 
ATOM   1289  N N   . PHE A 1 160 ? 22.436  -16.865 -19.634 1.00 100.82 ? 160 PHE A N   1 
ATOM   1290  C CA  . PHE A 1 160 ? 23.179  -18.104 -19.514 1.00 103.08 ? 160 PHE A CA  1 
ATOM   1291  C C   . PHE A 1 160 ? 23.566  -18.353 -18.046 1.00 95.37  ? 160 PHE A C   1 
ATOM   1292  O O   . PHE A 1 160 ? 23.439  -19.508 -17.581 1.00 96.36  ? 160 PHE A O   1 
ATOM   1293  C CB  . PHE A 1 160 ? 24.377  -17.981 -20.455 1.00 107.99 ? 160 PHE A CB  1 
ATOM   1294  C CG  . PHE A 1 160 ? 24.721  -19.337 -21.041 1.00 111.61 ? 160 PHE A CG  1 
ATOM   1295  C CD1 . PHE A 1 160 ? 23.901  -19.899 -22.013 1.00 105.17 ? 160 PHE A CD1 1 
ATOM   1296  C CD2 . PHE A 1 160 ? 25.817  -20.060 -20.584 1.00 117.08 ? 160 PHE A CD2 1 
ATOM   1297  C CE1 . PHE A 1 160 ? 24.188  -21.146 -22.534 1.00 109.26 ? 160 PHE A CE1 1 
ATOM   1298  C CE2 . PHE A 1 160 ? 26.102  -21.311 -21.111 1.00 120.38 ? 160 PHE A CE2 1 
ATOM   1299  C CZ  . PHE A 1 160 ? 25.289  -21.851 -22.086 1.00 117.50 ? 160 PHE A CZ  1 
ATOM   1300  N N   . GLU A 1 170 ? 31.995  -22.500 -25.320 1.00 73.08  ? 170 GLU A N   1 
ATOM   1301  C CA  . GLU A 1 170 ? 31.867  -21.057 -25.682 1.00 75.32  ? 170 GLU A CA  1 
ATOM   1302  C C   . GLU A 1 170 ? 30.450  -20.567 -25.368 1.00 67.70  ? 170 GLU A C   1 
ATOM   1303  O O   . GLU A 1 170 ? 29.480  -21.100 -25.884 1.00 62.18  ? 170 GLU A O   1 
ATOM   1304  C CB  . GLU A 1 170 ? 32.170  -20.822 -27.168 1.00 72.64  ? 170 GLU A CB  1 
ATOM   1305  C CG  . GLU A 1 170 ? 32.346  -19.347 -27.536 1.00 67.63  ? 170 GLU A CG  1 
ATOM   1306  C CD  . GLU A 1 170 ? 32.427  -19.024 -29.021 1.00 63.79  ? 170 GLU A CD  1 
ATOM   1307  O OE1 . GLU A 1 170 ? 32.546  -19.957 -29.842 1.00 66.25  ? 170 GLU A OE1 1 
ATOM   1308  O OE2 . GLU A 1 170 ? 32.348  -17.830 -29.375 1.00 56.34  ? 170 GLU A OE2 1 
ATOM   1309  N N   . THR A 1 171 ? 30.343  -19.556 -24.504 1.00 65.32  ? 171 THR A N   1 
ATOM   1310  C CA  . THR A 1 171 ? 29.080  -18.920 -24.163 1.00 60.00  ? 171 THR A CA  1 
ATOM   1311  C C   . THR A 1 171 ? 28.626  -18.029 -25.324 1.00 53.69  ? 171 THR A C   1 
ATOM   1312  O O   . THR A 1 171 ? 29.462  -17.589 -26.112 1.00 51.54  ? 171 THR A O   1 
ATOM   1313  C CB  . THR A 1 171 ? 29.321  -18.096 -22.899 1.00 65.16  ? 171 THR A CB  1 
ATOM   1314  O OG1 . THR A 1 171 ? 28.108  -17.478 -22.473 1.00 74.71  ? 171 THR A OG1 1 
ATOM   1315  C CG2 . THR A 1 171 ? 30.308  -16.968 -23.156 1.00 71.33  ? 171 THR A CG2 1 
ATOM   1316  N N   . PRO A 1 172 ? 27.317  -17.685 -25.444 1.00 42.90  ? 172 PRO A N   1 
ATOM   1317  C CA  . PRO A 1 172 ? 26.846  -16.693 -26.411 1.00 39.27  ? 172 PRO A CA  1 
ATOM   1318  C C   . PRO A 1 172 ? 27.182  -15.253 -26.047 1.00 36.15  ? 172 PRO A C   1 
ATOM   1319  O O   . PRO A 1 172 ? 27.069  -14.370 -26.876 1.00 39.52  ? 172 PRO A O   1 
ATOM   1320  C CB  . PRO A 1 172 ? 25.304  -16.900 -26.435 1.00 42.29  ? 172 PRO A CB  1 
ATOM   1321  C CG  . PRO A 1 172 ? 25.071  -18.192 -25.691 1.00 43.42  ? 172 PRO A CG  1 
ATOM   1322  C CD  . PRO A 1 172 ? 26.201  -18.250 -24.676 1.00 43.48  ? 172 PRO A CD  1 
ATOM   1323  N N   . MET A 1 173 ? 27.513  -15.013 -24.784 1.00 39.50  ? 173 MET A N   1 
ATOM   1324  C CA  . MET A 1 173 ? 27.996  -13.728 -24.305 1.00 42.55  ? 173 MET A CA  1 
ATOM   1325  C C   . MET A 1 173 ? 29.194  -13.289 -25.139 1.00 46.93  ? 173 MET A C   1 
ATOM   1326  O O   . MET A 1 173 ? 29.997  -14.113 -25.546 1.00 47.62  ? 173 MET A O   1 
ATOM   1327  C CB  . MET A 1 173 ? 28.466  -13.881 -22.851 1.00 44.94  ? 173 MET A CB  1 
ATOM   1328  C CG  . MET A 1 173 ? 28.905  -12.604 -22.175 1.00 56.11  ? 173 MET A CG  1 
ATOM   1329  S SD  . MET A 1 173 ? 29.550  -12.855 -20.507 1.00 63.34  ? 173 MET A SD  1 
ATOM   1330  C CE  . MET A 1 173 ? 28.506  -14.129 -19.781 1.00 78.62  ? 173 MET A CE  1 
ATOM   1331  N N   . LEU A 1 174 ? 29.359  -11.980 -25.323 1.00 43.87  ? 174 LEU A N   1 
ATOM   1332  C CA  . LEU A 1 174 ? 30.523  -11.458 -26.014 1.00 39.90  ? 174 LEU A CA  1 
ATOM   1333  C C   . LEU A 1 174 ? 31.777  -11.875 -25.258 1.00 45.53  ? 174 LEU A C   1 
ATOM   1334  O O   . LEU A 1 174 ? 31.814  -11.761 -24.035 1.00 46.18  ? 174 LEU A O   1 
ATOM   1335  C CB  . LEU A 1 174 ? 30.440  -9.938  -26.061 1.00 37.11  ? 174 LEU A CB  1 
ATOM   1336  C CG  . LEU A 1 174 ? 31.539  -9.241  -26.855 1.00 36.52  ? 174 LEU A CG  1 
ATOM   1337  C CD1 . LEU A 1 174 ? 31.391  -9.668  -28.317 1.00 41.73  ? 174 LEU A CD1 1 
ATOM   1338  C CD2 . LEU A 1 174 ? 31.458  -7.752  -26.727 1.00 35.18  ? 174 LEU A CD2 1 
ATOM   1339  N N   . SER A 1 175 ? 32.798  -12.327 -25.999 1.00 43.36  ? 175 SER A N   1 
ATOM   1340  C CA  . SER A 1 175 ? 34.066  -12.751 -25.418 1.00 36.59  ? 175 SER A CA  1 
ATOM   1341  C C   . SER A 1 175 ? 35.163  -12.703 -26.468 1.00 39.81  ? 175 SER A C   1 
ATOM   1342  O O   . SER A 1 175 ? 34.893  -12.790 -27.660 1.00 39.69  ? 175 SER A O   1 
ATOM   1343  C CB  . SER A 1 175 ? 34.000  -14.119 -24.839 1.00 40.12  ? 175 SER A CB  1 
ATOM   1344  O OG  . SER A 1 175 ? 33.827  -15.089 -25.854 1.00 37.82  ? 175 SER A OG  1 
ATOM   1345  N N   . ILE A 1 176 ? 36.401  -12.535 -25.984 1.00 46.12  ? 176 ILE A N   1 
ATOM   1346  C CA  . ILE A 1 176 ? 37.594  -12.453 -26.809 1.00 42.02  ? 176 ILE A CA  1 
ATOM   1347  C C   . ILE A 1 176 ? 37.901  -13.836 -27.367 1.00 38.90  ? 176 ILE A C   1 
ATOM   1348  O O   . ILE A 1 176 ? 37.969  -14.782 -26.596 1.00 42.79  ? 176 ILE A O   1 
ATOM   1349  C CB  . ILE A 1 176 ? 38.755  -11.959 -25.938 1.00 47.24  ? 176 ILE A CB  1 
ATOM   1350  C CG1 . ILE A 1 176 ? 38.428  -10.645 -25.299 1.00 48.21  ? 176 ILE A CG1 1 
ATOM   1351  C CG2 . ILE A 1 176 ? 40.042  -11.895 -26.753 1.00 50.96  ? 176 ILE A CG2 1 
ATOM   1352  C CD1 . ILE A 1 176 ? 39.394  -10.232 -24.211 1.00 49.76  ? 176 ILE A CD1 1 
ATOM   1353  N N   . VAL A 1 177 ? 38.119  -13.954 -28.683 1.00 43.72  ? 177 VAL A N   1 
ATOM   1354  C CA  . VAL A 1 177 ? 38.449  -15.245 -29.284 1.00 44.50  ? 177 VAL A CA  1 
ATOM   1355  C C   . VAL A 1 177 ? 39.814  -15.224 -29.970 1.00 46.30  ? 177 VAL A C   1 
ATOM   1356  O O   . VAL A 1 177 ? 40.277  -16.267 -30.408 1.00 44.85  ? 177 VAL A O   1 
ATOM   1357  C CB  . VAL A 1 177 ? 37.380  -15.664 -30.298 1.00 47.96  ? 177 VAL A CB  1 
ATOM   1358  C CG1 . VAL A 1 177 ? 36.042  -15.941 -29.618 1.00 48.79  ? 177 VAL A CG1 1 
ATOM   1359  C CG2 . VAL A 1 177 ? 37.244  -14.624 -31.405 1.00 47.05  ? 177 VAL A CG2 1 
ATOM   1360  N N   . GLU A 1 178 ? 40.412  -14.038 -30.100 1.00 46.04  ? 178 GLU A N   1 
ATOM   1361  C CA  . GLU A 1 178 ? 41.794  -13.880 -30.514 1.00 49.19  ? 178 GLU A CA  1 
ATOM   1362  C C   . GLU A 1 178 ? 42.354  -12.573 -29.948 1.00 51.96  ? 178 GLU A C   1 
ATOM   1363  O O   . GLU A 1 178 ? 41.628  -11.579 -29.871 1.00 50.71  ? 178 GLU A O   1 
ATOM   1364  C CB  . GLU A 1 178 ? 41.882  -13.819 -32.037 1.00 55.37  ? 178 GLU A CB  1 
ATOM   1365  C CG  . GLU A 1 178 ? 43.297  -13.680 -32.602 1.00 51.61  ? 178 GLU A CG  1 
ATOM   1366  C CD  . GLU A 1 178 ? 43.311  -13.457 -34.106 1.00 51.93  ? 178 GLU A CD  1 
ATOM   1367  O OE1 . GLU A 1 178 ? 42.580  -14.136 -34.868 1.00 54.92  ? 178 GLU A OE1 1 
ATOM   1368  O OE2 . GLU A 1 178 ? 44.058  -12.559 -34.512 1.00 53.26  ? 178 GLU A OE2 1 
ATOM   1369  N N   . GLN A 1 179 ? 43.636  -12.610 -29.539 1.00 53.69  ? 179 GLN A N   1 
ATOM   1370  C CA  . GLN A 1 179 ? 44.438  -11.426 -29.280 1.00 52.09  ? 179 GLN A CA  1 
ATOM   1371  C C   . GLN A 1 179 ? 45.621  -11.442 -30.238 1.00 56.50  ? 179 GLN A C   1 
ATOM   1372  O O   . GLN A 1 179 ? 46.171  -12.503 -30.495 1.00 59.96  ? 179 GLN A O   1 
ATOM   1373  C CB  . GLN A 1 179 ? 44.915  -11.417 -27.829 1.00 54.38  ? 179 GLN A CB  1 
ATOM   1374  C CG  . GLN A 1 179 ? 43.771  -11.529 -26.821 1.00 54.55  ? 179 GLN A CG  1 
ATOM   1375  C CD  . GLN A 1 179 ? 44.161  -11.251 -25.387 1.00 48.16  ? 179 GLN A CD  1 
ATOM   1376  O OE1 . GLN A 1 179 ? 45.117  -10.534 -25.100 1.00 56.05  ? 179 GLN A OE1 1 
ATOM   1377  N NE2 . GLN A 1 179 ? 43.385  -11.781 -24.457 1.00 52.50  ? 179 GLN A NE2 1 
ATOM   1378  N N   . ASN A 1 180 ? 45.958  -10.283 -30.809 1.00 55.08  ? 180 ASN A N   1 
ATOM   1379  C CA  . ASN A 1 180 ? 47.098  -10.170 -31.699 1.00 55.28  ? 180 ASN A CA  1 
ATOM   1380  C C   . ASN A 1 180 ? 47.691  -8.765  -31.573 1.00 64.00  ? 180 ASN A C   1 
ATOM   1381  O O   . ASN A 1 180 ? 47.152  -7.935  -30.851 1.00 71.05  ? 180 ASN A O   1 
ATOM   1382  C CB  . ASN A 1 180 ? 46.737  -10.541 -33.129 1.00 45.22  ? 180 ASN A CB  1 
ATOM   1383  C CG  . ASN A 1 180 ? 45.825  -9.527  -33.765 1.00 46.38  ? 180 ASN A CG  1 
ATOM   1384  O OD1 . ASN A 1 180 ? 46.044  -8.314  -33.653 1.00 46.26  ? 180 ASN A OD1 1 
ATOM   1385  N ND2 . ASN A 1 180 ? 44.789  -10.003 -34.438 1.00 46.82  ? 180 ASN A ND2 1 
ATOM   1386  N N   . ASP A 1 181 ? 48.801  -8.510  -32.284 1.00 58.89  ? 181 ASP A N   1 
ATOM   1387  C CA  . ASP A 1 181 ? 49.589  -7.298  -32.111 1.00 57.41  ? 181 ASP A CA  1 
ATOM   1388  C C   . ASP A 1 181 ? 48.776  -6.076  -32.503 1.00 49.51  ? 181 ASP A C   1 
ATOM   1389  O O   . ASP A 1 181 ? 49.081  -4.970  -32.054 1.00 46.64  ? 181 ASP A O   1 
ATOM   1390  C CB  . ASP A 1 181 ? 50.868  -7.302  -32.948 1.00 64.53  ? 181 ASP A CB  1 
ATOM   1391  C CG  . ASP A 1 181 ? 51.935  -8.345  -32.617 1.00 64.52  ? 181 ASP A CG  1 
ATOM   1392  O OD1 . ASP A 1 181 ? 51.840  -9.009  -31.554 1.00 55.21  ? 181 ASP A OD1 1 
ATOM   1393  O OD2 . ASP A 1 181 ? 52.865  -8.494  -33.444 1.00 69.85  ? 181 ASP A OD2 1 
ATOM   1394  N N   . GLN A 1 182 ? 47.782  -6.270  -33.381 1.00 49.83  ? 182 GLN A N   1 
ATOM   1395  C CA  . GLN A 1 182 ? 47.003  -5.146  -33.865 1.00 49.37  ? 182 GLN A CA  1 
ATOM   1396  C C   . GLN A 1 182 ? 45.862  -4.836  -32.891 1.00 46.54  ? 182 GLN A C   1 
ATOM   1397  O O   . GLN A 1 182 ? 45.485  -3.671  -32.748 1.00 44.06  ? 182 GLN A O   1 
ATOM   1398  C CB  . GLN A 1 182 ? 46.530  -5.294  -35.313 1.00 57.71  ? 182 GLN A CB  1 
ATOM   1399  C CG  . GLN A 1 182 ? 46.627  -3.966  -36.069 1.00 71.80  ? 182 GLN A CG  1 
ATOM   1400  C CD  . GLN A 1 182 ? 45.778  -3.829  -37.322 1.00 68.56  ? 182 GLN A CD  1 
ATOM   1401  O OE1 . GLN A 1 182 ? 45.667  -4.757  -38.137 1.00 70.80  ? 182 GLN A OE1 1 
ATOM   1402  N NE2 . GLN A 1 182 ? 45.192  -2.642  -37.491 1.00 55.23  ? 182 GLN A NE2 1 
ATOM   1403  N N   . GLY A 1 183 ? 45.339  -5.850  -32.191 1.00 45.76  ? 183 GLY A N   1 
ATOM   1404  C CA  . GLY A 1 183 ? 44.176  -5.634  -31.338 1.00 52.08  ? 183 GLY A CA  1 
ATOM   1405  C C   . GLY A 1 183 ? 43.493  -6.945  -30.973 1.00 51.35  ? 183 GLY A C   1 
ATOM   1406  O O   . GLY A 1 183 ? 44.162  -7.972  -30.939 1.00 49.19  ? 183 GLY A O   1 
ATOM   1407  N N   . ILE A 1 184 ? 42.160  -6.916  -30.740 1.00 48.02  ? 184 ILE A N   1 
ATOM   1408  C CA  . ILE A 1 184 ? 41.455  -8.118  -30.309 1.00 39.56  ? 184 ILE A CA  1 
ATOM   1409  C C   . ILE A 1 184 ? 40.324  -8.416  -31.282 1.00 40.98  ? 184 ILE A C   1 
ATOM   1410  O O   . ILE A 1 184 ? 39.891  -7.539  -32.024 1.00 43.04  ? 184 ILE A O   1 
ATOM   1411  C CB  . ILE A 1 184 ? 40.931  -7.994  -28.866 1.00 38.20  ? 184 ILE A CB  1 
ATOM   1412  C CG1 . ILE A 1 184 ? 39.825  -6.951  -28.691 1.00 38.05  ? 184 ILE A CG1 1 
ATOM   1413  C CG2 . ILE A 1 184 ? 42.058  -7.705  -27.889 1.00 35.22  ? 184 ILE A CG2 1 
ATOM   1414  C CD1 . ILE A 1 184 ? 39.303  -6.866  -27.266 1.00 36.14  ? 184 ILE A CD1 1 
ATOM   1415  N N   . VAL A 1 185 ? 39.869  -9.670  -31.246 1.00 40.74  ? 185 VAL A N   1 
ATOM   1416  C CA  . VAL A 1 185 ? 38.678  -10.105 -31.945 1.00 40.85  ? 185 VAL A CA  1 
ATOM   1417  C C   . VAL A 1 185 ? 37.689  -10.667 -30.921 1.00 42.03  ? 185 VAL A C   1 
ATOM   1418  O O   . VAL A 1 185 ? 38.080  -11.440 -30.046 1.00 49.87  ? 185 VAL A O   1 
ATOM   1419  C CB  . VAL A 1 185 ? 39.062  -11.141 -33.018 1.00 43.54  ? 185 VAL A CB  1 
ATOM   1420  C CG1 . VAL A 1 185 ? 37.848  -11.714 -33.736 1.00 42.44  ? 185 VAL A CG1 1 
ATOM   1421  C CG2 . VAL A 1 185 ? 40.021  -10.545 -34.040 1.00 41.53  ? 185 VAL A CG2 1 
ATOM   1422  N N   . VAL A 1 186 ? 36.412  -10.279 -31.046 1.00 39.25  ? 186 VAL A N   1 
ATOM   1423  C CA  . VAL A 1 186 ? 35.365  -10.616 -30.087 1.00 39.68  ? 186 VAL A CA  1 
ATOM   1424  C C   . VAL A 1 186 ? 34.196  -11.241 -30.834 1.00 44.87  ? 186 VAL A C   1 
ATOM   1425  O O   . VAL A 1 186 ? 33.881  -10.852 -31.967 1.00 43.71  ? 186 VAL A O   1 
ATOM   1426  C CB  . VAL A 1 186 ? 34.872  -9.377  -29.320 1.00 41.37  ? 186 VAL A CB  1 
ATOM   1427  C CG1 . VAL A 1 186 ? 35.991  -8.671  -28.563 1.00 42.28  ? 186 VAL A CG1 1 
ATOM   1428  C CG2 . VAL A 1 186 ? 34.194  -8.362  -30.235 1.00 43.42  ? 186 VAL A CG2 1 
ATOM   1429  N N   . ARG A 1 187 ? 33.542  -12.200 -30.175 1.00 45.39  ? 187 ARG A N   1 
ATOM   1430  C CA  . ARG A 1 187 ? 32.398  -12.854 -30.766 1.00 45.04  ? 187 ARG A CA  1 
ATOM   1431  C C   . ARG A 1 187 ? 31.317  -13.028 -29.707 1.00 42.23  ? 187 ARG A C   1 
ATOM   1432  O O   . ARG A 1 187 ? 31.646  -13.302 -28.559 1.00 41.02  ? 187 ARG A O   1 
ATOM   1433  C CB  . ARG A 1 187 ? 32.841  -14.200 -31.327 1.00 47.85  ? 187 ARG A CB  1 
ATOM   1434  C CG  . ARG A 1 187 ? 31.715  -14.866 -32.102 1.00 53.15  ? 187 ARG A CG  1 
ATOM   1435  C CD  . ARG A 1 187 ? 32.175  -15.995 -33.023 1.00 53.60  ? 187 ARG A CD  1 
ATOM   1436  N NE  . ARG A 1 187 ? 32.785  -17.099 -32.272 1.00 54.74  ? 187 ARG A NE  1 
ATOM   1437  C CZ  . ARG A 1 187 ? 34.025  -17.525 -32.462 1.00 53.04  ? 187 ARG A CZ  1 
ATOM   1438  N NH1 . ARG A 1 187 ? 34.779  -17.005 -33.417 1.00 49.75  ? 187 ARG A NH1 1 
ATOM   1439  N NH2 . ARG A 1 187 ? 34.512  -18.448 -31.666 1.00 51.83  ? 187 ARG A NH2 1 
ATOM   1440  N N   . GLY A 1 188 ? 30.049  -12.856 -30.121 1.00 40.84  ? 188 GLY A N   1 
ATOM   1441  C CA  . GLY A 1 188 ? 28.865  -13.050 -29.281 1.00 38.04  ? 188 GLY A CA  1 
ATOM   1442  C C   . GLY A 1 188 ? 27.986  -11.798 -29.185 1.00 38.97  ? 188 GLY A C   1 
ATOM   1443  O O   . GLY A 1 188 ? 28.162  -10.827 -29.915 1.00 39.55  ? 188 GLY A O   1 
ATOM   1444  N N   . TRP A 1 189 ? 27.086  -11.805 -28.205 1.00 39.34  ? 189 TRP A N   1 
ATOM   1445  C CA  . TRP A 1 189 ? 26.047  -10.806 -28.063 1.00 34.07  ? 189 TRP A CA  1 
ATOM   1446  C C   . TRP A 1 189 ? 26.341  -9.822  -26.944 1.00 35.84  ? 189 TRP A C   1 
ATOM   1447  O O   . TRP A 1 189 ? 26.823  -10.238 -25.899 1.00 32.01  ? 189 TRP A O   1 
ATOM   1448  C CB  . TRP A 1 189 ? 24.752  -11.529 -27.707 1.00 33.80  ? 189 TRP A CB  1 
ATOM   1449  C CG  . TRP A 1 189 ? 24.184  -12.365 -28.816 1.00 34.79  ? 189 TRP A CG  1 
ATOM   1450  C CD1 . TRP A 1 189 ? 24.335  -13.703 -29.016 1.00 34.94  ? 189 TRP A CD1 1 
ATOM   1451  C CD2 . TRP A 1 189 ? 23.300  -11.897 -29.851 1.00 31.34  ? 189 TRP A CD2 1 
ATOM   1452  N NE1 . TRP A 1 189 ? 23.634  -14.086 -30.129 1.00 36.49  ? 189 TRP A NE1 1 
ATOM   1453  C CE2 . TRP A 1 189 ? 22.987  -13.008 -30.652 1.00 32.77  ? 189 TRP A CE2 1 
ATOM   1454  C CE3 . TRP A 1 189 ? 22.767  -10.650 -30.175 1.00 34.48  ? 189 TRP A CE3 1 
ATOM   1455  C CZ2 . TRP A 1 189 ? 22.164  -12.912 -31.761 1.00 38.84  ? 189 TRP A CZ2 1 
ATOM   1456  C CZ3 . TRP A 1 189 ? 21.939  -10.554 -31.266 1.00 35.44  ? 189 TRP A CZ3 1 
ATOM   1457  C CH2 . TRP A 1 189 ? 21.637  -11.674 -32.040 1.00 38.15  ? 189 TRP A CH2 1 
ATOM   1458  N N   . LYS A 1 190 ? 25.940  -8.549  -27.131 1.00 34.52  ? 190 LYS A N   1 
ATOM   1459  C CA  . LYS A 1 190 ? 25.600  -7.695  -26.009 1.00 33.31  ? 190 LYS A CA  1 
ATOM   1460  C C   . LYS A 1 190 ? 24.082  -7.590  -25.935 1.00 36.43  ? 190 LYS A C   1 
ATOM   1461  O O   . LYS A 1 190 ? 23.448  -7.453  -26.968 1.00 36.77  ? 190 LYS A O   1 
ATOM   1462  C CB  . LYS A 1 190 ? 26.227  -6.315  -26.132 1.00 34.26  ? 190 LYS A CB  1 
ATOM   1463  C CG  . LYS A 1 190 ? 27.724  -6.361  -26.097 1.00 37.39  ? 190 LYS A CG  1 
ATOM   1464  C CD  . LYS A 1 190 ? 28.277  -6.985  -24.820 1.00 37.41  ? 190 LYS A CD  1 
ATOM   1465  C CE  . LYS A 1 190 ? 28.071  -6.153  -23.620 1.00 35.71  ? 190 LYS A CE  1 
ATOM   1466  N NZ  . LYS A 1 190 ? 28.615  -6.853  -22.446 1.00 38.98  ? 190 LYS A NZ  1 
ATOM   1467  N N   . ALA A 1 191 ? 23.515  -7.646  -24.714 1.00 41.31  ? 191 ALA A N   1 
ATOM   1468  C CA  . ALA A 1 191 ? 22.107  -7.990  -24.553 1.00 42.99  ? 191 ALA A CA  1 
ATOM   1469  C C   . ALA A 1 191 ? 21.206  -6.782  -24.681 1.00 41.56  ? 191 ALA A C   1 
ATOM   1470  O O   . ALA A 1 191 ? 20.049  -6.951  -25.020 1.00 45.31  ? 191 ALA A O   1 
ATOM   1471  C CB  . ALA A 1 191 ? 21.824  -8.656  -23.245 1.00 48.47  ? 191 ALA A CB  1 
ATOM   1472  N N   . MET A 1 192 ? 21.678  -5.580  -24.358 1.00 41.96  ? 192 MET A N   1 
ATOM   1473  C CA  . MET A 1 192 ? 20.758  -4.481  -24.486 1.00 42.43  ? 192 MET A CA  1 
ATOM   1474  C C   . MET A 1 192 ? 21.467  -3.153  -24.448 1.00 42.27  ? 192 MET A C   1 
ATOM   1475  O O   . MET A 1 192 ? 22.472  -3.018  -23.769 1.00 49.12  ? 192 MET A O   1 
ATOM   1476  C CB  . MET A 1 192 ? 19.726  -4.419  -23.365 1.00 58.19  ? 192 MET A CB  1 
ATOM   1477  C CG  . MET A 1 192 ? 18.331  -4.196  -23.938 1.00 76.24  ? 192 MET A CG  1 
ATOM   1478  S SD  . MET A 1 192 ? 17.382  -3.032  -22.958 1.00 92.57  ? 192 MET A SD  1 
ATOM   1479  C CE  . MET A 1 192 ? 17.693  -3.690  -21.310 1.00 84.10  ? 192 MET A CE  1 
ATOM   1480  N N   . GLY A 1 193 ? 20.900  -2.226  -25.221 1.00 32.05  ? 193 GLY A N   1 
ATOM   1481  C CA  . GLY A 1 193 ? 21.436  -0.902  -25.397 1.00 30.71  ? 193 GLY A CA  1 
ATOM   1482  C C   . GLY A 1 193 ? 20.381  -0.044  -26.075 1.00 33.97  ? 193 GLY A C   1 
ATOM   1483  O O   . GLY A 1 193 ? 19.457  -0.581  -26.672 1.00 37.44  ? 193 GLY A O   1 
ATOM   1484  N N   . THR A 1 194 ? 20.536  1.270   -25.939 1.00 32.34  ? 194 THR A N   1 
ATOM   1485  C CA  . THR A 1 194 ? 19.535  2.226   -26.327 1.00 33.07  ? 194 THR A CA  1 
ATOM   1486  C C   . THR A 1 194 ? 20.135  3.210   -27.325 1.00 33.98  ? 194 THR A C   1 
ATOM   1487  O O   . THR A 1 194 ? 21.325  3.528   -27.286 1.00 30.90  ? 194 THR A O   1 
ATOM   1488  C CB  . THR A 1 194 ? 19.009  2.926   -25.075 1.00 39.85  ? 194 THR A CB  1 
ATOM   1489  O OG1 . THR A 1 194 ? 18.426  1.902   -24.259 1.00 38.96  ? 194 THR A OG1 1 
ATOM   1490  C CG2 . THR A 1 194 ? 17.927  3.934   -25.412 1.00 39.70  ? 194 THR A CG2 1 
ATOM   1491  N N   . SER A 1 195 ? 19.288  3.571   -28.285 1.00 29.49  ? 195 SER A N   1 
ATOM   1492  C CA  . SER A 1 195 ? 19.604  4.475   -29.358 1.00 30.75  ? 195 SER A CA  1 
ATOM   1493  C C   . SER A 1 195 ? 20.651  3.924   -30.317 1.00 31.40  ? 195 SER A C   1 
ATOM   1494  O O   . SER A 1 195 ? 21.293  4.705   -30.984 1.00 36.09  ? 195 SER A O   1 
ATOM   1495  C CB  . SER A 1 195 ? 20.089  5.728   -28.776 1.00 36.02  ? 195 SER A CB  1 
ATOM   1496  O OG  . SER A 1 195 ? 19.283  6.121   -27.697 1.00 35.49  ? 195 SER A OG  1 
ATOM   1497  N N   . LEU A 1 196 ? 20.834  2.610   -30.386 1.00 37.41  ? 196 LEU A N   1 
ATOM   1498  C CA  . LEU A 1 196 ? 21.937  2.004   -31.117 1.00 36.12  ? 196 LEU A CA  1 
ATOM   1499  C C   . LEU A 1 196 ? 22.008  2.490   -32.563 1.00 35.86  ? 196 LEU A C   1 
ATOM   1500  O O   . LEU A 1 196 ? 23.076  2.860   -33.047 1.00 38.04  ? 196 LEU A O   1 
ATOM   1501  C CB  . LEU A 1 196 ? 21.828  0.486   -31.074 1.00 33.92  ? 196 LEU A CB  1 
ATOM   1502  C CG  . LEU A 1 196 ? 21.844  -0.140  -29.687 1.00 37.41  ? 196 LEU A CG  1 
ATOM   1503  C CD1 . LEU A 1 196 ? 22.043  -1.644  -29.763 1.00 41.34  ? 196 LEU A CD1 1 
ATOM   1504  C CD2 . LEU A 1 196 ? 22.890  0.479   -28.815 1.00 44.33  ? 196 LEU A CD2 1 
ATOM   1505  N N   . PRO A 1 197 ? 20.896  2.524   -33.319 1.00 32.99  ? 197 PRO A N   1 
ATOM   1506  C CA  . PRO A 1 197 ? 20.959  2.944   -34.701 1.00 30.32  ? 197 PRO A CA  1 
ATOM   1507  C C   . PRO A 1 197 ? 21.288  4.410   -34.883 1.00 30.88  ? 197 PRO A C   1 
ATOM   1508  O O   . PRO A 1 197 ? 21.396  4.831   -36.030 1.00 36.51  ? 197 PRO A O   1 
ATOM   1509  C CB  . PRO A 1 197 ? 19.559  2.654   -35.219 1.00 31.37  ? 197 PRO A CB  1 
ATOM   1510  C CG  . PRO A 1 197 ? 18.976  1.736   -34.240 1.00 34.64  ? 197 PRO A CG  1 
ATOM   1511  C CD  . PRO A 1 197 ? 19.541  2.173   -32.917 1.00 35.83  ? 197 PRO A CD  1 
ATOM   1512  N N   . PHE A 1 198 ? 21.362  5.190   -33.797 1.00 29.05  ? 198 PHE A N   1 
ATOM   1513  C CA  . PHE A 1 198 ? 21.450  6.642   -33.894 1.00 27.39  ? 198 PHE A CA  1 
ATOM   1514  C C   . PHE A 1 198 ? 22.738  7.179   -33.280 1.00 29.36  ? 198 PHE A C   1 
ATOM   1515  O O   . PHE A 1 198 ? 22.842  8.395   -33.077 1.00 32.13  ? 198 PHE A O   1 
ATOM   1516  C CB  . PHE A 1 198 ? 20.223  7.264   -33.236 1.00 29.91  ? 198 PHE A CB  1 
ATOM   1517  C CG  . PHE A 1 198 ? 18.907  6.701   -33.773 1.00 31.87  ? 198 PHE A CG  1 
ATOM   1518  C CD1 . PHE A 1 198 ? 18.401  7.111   -34.999 1.00 35.24  ? 198 PHE A CD1 1 
ATOM   1519  C CD2 . PHE A 1 198 ? 18.188  5.753   -33.061 1.00 32.35  ? 198 PHE A CD2 1 
ATOM   1520  C CE1 . PHE A 1 198 ? 17.220  6.567   -35.501 1.00 38.27  ? 198 PHE A CE1 1 
ATOM   1521  C CE2 . PHE A 1 198 ? 16.988  5.238   -33.550 1.00 34.15  ? 198 PHE A CE2 1 
ATOM   1522  C CZ  . PHE A 1 198 ? 16.514  5.631   -34.774 1.00 32.73  ? 198 PHE A CZ  1 
ATOM   1523  N N   . VAL A 1 199 ? 23.720  6.298   -33.034 1.00 28.08  ? 199 VAL A N   1 
ATOM   1524  C CA  . VAL A 1 199 ? 25.024  6.726   -32.549 1.00 31.91  ? 199 VAL A CA  1 
ATOM   1525  C C   . VAL A 1 199 ? 26.136  6.280   -33.495 1.00 31.14  ? 199 VAL A C   1 
ATOM   1526  O O   . VAL A 1 199 ? 25.929  5.509   -34.414 1.00 40.48  ? 199 VAL A O   1 
ATOM   1527  C CB  . VAL A 1 199 ? 25.269  6.214   -31.123 1.00 30.53  ? 199 VAL A CB  1 
ATOM   1528  C CG1 . VAL A 1 199 ? 24.183  6.730   -30.198 1.00 35.87  ? 199 VAL A CG1 1 
ATOM   1529  C CG2 . VAL A 1 199 ? 25.345  4.710   -31.028 1.00 27.91  ? 199 VAL A CG2 1 
ATOM   1530  N N   . ASN A 1 200 ? 27.325  6.819   -33.281 1.00 31.19  ? 200 ASN A N   1 
ATOM   1531  C CA  . ASN A 1 200 ? 28.468  6.551   -34.133 1.00 28.87  ? 200 ASN A CA  1 
ATOM   1532  C C   . ASN A 1 200 ? 29.255  5.368   -33.580 1.00 33.19  ? 200 ASN A C   1 
ATOM   1533  O O   . ASN A 1 200 ? 29.749  4.550   -34.343 1.00 30.89  ? 200 ASN A O   1 
ATOM   1534  C CB  . ASN A 1 200 ? 29.316  7.797   -34.228 1.00 28.62  ? 200 ASN A CB  1 
ATOM   1535  C CG  . ASN A 1 200 ? 28.498  8.967   -34.714 1.00 32.90  ? 200 ASN A CG  1 
ATOM   1536  O OD1 . ASN A 1 200 ? 28.308  9.963   -33.997 1.00 33.09  ? 200 ASN A OD1 1 
ATOM   1537  N ND2 . ASN A 1 200 ? 27.984  8.856   -35.927 1.00 36.73  ? 200 ASN A ND2 1 
ATOM   1538  N N   . GLU A 1 201 ? 29.316  5.232   -32.244 1.00 37.19  ? 201 GLU A N   1 
ATOM   1539  C CA  . GLU A 1 201 ? 30.171  4.230   -31.618 1.00 35.98  ? 201 GLU A CA  1 
ATOM   1540  C C   . GLU A 1 201 ? 29.467  3.688   -30.386 1.00 32.28  ? 201 GLU A C   1 
ATOM   1541  O O   . GLU A 1 201 ? 28.767  4.439   -29.745 1.00 34.95  ? 201 GLU A O   1 
ATOM   1542  C CB  . GLU A 1 201 ? 31.510  4.868   -31.219 1.00 36.95  ? 201 GLU A CB  1 
ATOM   1543  C CG  . GLU A 1 201 ? 32.240  5.528   -32.388 1.00 39.33  ? 201 GLU A CG  1 
ATOM   1544  C CD  . GLU A 1 201 ? 33.637  6.105   -32.162 1.00 39.53  ? 201 GLU A CD  1 
ATOM   1545  O OE1 . GLU A 1 201 ? 34.147  6.007   -31.057 1.00 43.66  ? 201 GLU A OE1 1 
ATOM   1546  O OE2 . GLU A 1 201 ? 34.218  6.700   -33.081 1.00 39.72  ? 201 GLU A OE2 1 
ATOM   1547  N N   . LEU A 1 202 ? 29.702  2.414   -30.064 1.00 32.00  ? 202 LEU A N   1 
ATOM   1548  C CA  . LEU A 1 202 ? 29.291  1.792   -28.825 1.00 30.36  ? 202 LEU A CA  1 
ATOM   1549  C C   . LEU A 1 202 ? 30.391  1.803   -27.770 1.00 35.29  ? 202 LEU A C   1 
ATOM   1550  O O   . LEU A 1 202 ? 31.560  1.563   -28.075 1.00 32.40  ? 202 LEU A O   1 
ATOM   1551  C CB  . LEU A 1 202 ? 28.984  0.351   -29.173 1.00 31.89  ? 202 LEU A CB  1 
ATOM   1552  C CG  . LEU A 1 202 ? 27.898  0.119   -30.220 1.00 32.63  ? 202 LEU A CG  1 
ATOM   1553  C CD1 . LEU A 1 202 ? 27.697  -1.365  -30.386 1.00 29.81  ? 202 LEU A CD1 1 
ATOM   1554  C CD2 . LEU A 1 202 ? 26.628  0.787   -29.825 1.00 32.28  ? 202 LEU A CD2 1 
ATOM   1555  N N   . LEU A 1 203 ? 29.999  2.002   -26.501 1.00 35.73  ? 203 LEU A N   1 
ATOM   1556  C CA  . LEU A 1 203 ? 30.890  1.749   -25.378 1.00 34.16  ? 203 LEU A CA  1 
ATOM   1557  C C   . LEU A 1 203 ? 30.558  0.392   -24.800 1.00 35.11  ? 203 LEU A C   1 
ATOM   1558  O O   . LEU A 1 203 ? 29.601  0.316   -24.055 1.00 34.60  ? 203 LEU A O   1 
ATOM   1559  C CB  . LEU A 1 203 ? 30.656  2.816   -24.325 1.00 34.77  ? 203 LEU A CB  1 
ATOM   1560  C CG  . LEU A 1 203 ? 31.070  4.224   -24.739 1.00 37.01  ? 203 LEU A CG  1 
ATOM   1561  C CD1 . LEU A 1 203 ? 30.438  5.371   -23.933 1.00 39.88  ? 203 LEU A CD1 1 
ATOM   1562  C CD2 . LEU A 1 203 ? 32.561  4.228   -24.562 1.00 41.73  ? 203 LEU A CD2 1 
ATOM   1563  N N   . VAL A 1 204 ? 31.285  -0.676  -25.148 1.00 37.26  ? 204 VAL A N   1 
ATOM   1564  C CA  . VAL A 1 204 ? 30.863  -1.966  -24.648 1.00 37.72  ? 204 VAL A CA  1 
ATOM   1565  C C   . VAL A 1 204 ? 31.586  -2.189  -23.336 1.00 38.47  ? 204 VAL A C   1 
ATOM   1566  O O   . VAL A 1 204 ? 32.710  -1.761  -23.190 1.00 39.05  ? 204 VAL A O   1 
ATOM   1567  C CB  . VAL A 1 204 ? 31.034  -3.169  -25.587 1.00 39.84  ? 204 VAL A CB  1 
ATOM   1568  C CG1 . VAL A 1 204 ? 30.647  -2.816  -27.012 1.00 38.61  ? 204 VAL A CG1 1 
ATOM   1569  C CG2 . VAL A 1 204 ? 32.433  -3.717  -25.562 1.00 49.47  ? 204 VAL A CG2 1 
ATOM   1570  N N   . GLY A 1 205 ? 30.931  -2.909  -22.426 1.00 42.35  ? 205 GLY A N   1 
ATOM   1571  C CA  . GLY A 1 205 ? 31.491  -3.256  -21.135 1.00 40.20  ? 205 GLY A CA  1 
ATOM   1572  C C   . GLY A 1 205 ? 30.692  -4.374  -20.471 1.00 39.70  ? 205 GLY A C   1 
ATOM   1573  O O   . GLY A 1 205 ? 29.751  -4.890  -21.056 1.00 45.44  ? 205 GLY A O   1 
ATOM   1574  N N   . ASN A 1 206 ? 31.094  -4.725  -19.249 1.00 42.32  ? 206 ASN A N   1 
ATOM   1575  C CA  . ASN A 1 206 ? 30.441  -5.734  -18.439 1.00 44.57  ? 206 ASN A CA  1 
ATOM   1576  C C   . ASN A 1 206 ? 30.152  -5.195  -17.047 1.00 46.67  ? 206 ASN A C   1 
ATOM   1577  O O   . ASN A 1 206 ? 30.874  -4.335  -16.554 1.00 40.36  ? 206 ASN A O   1 
ATOM   1578  C CB  . ASN A 1 206 ? 31.335  -6.938  -18.227 1.00 46.26  ? 206 ASN A CB  1 
ATOM   1579  C CG  . ASN A 1 206 ? 31.798  -7.457  -19.554 1.00 47.31  ? 206 ASN A CG  1 
ATOM   1580  O OD1 . ASN A 1 206 ? 32.889  -7.109  -20.001 1.00 47.21  ? 206 ASN A OD1 1 
ATOM   1581  N ND2 . ASN A 1 206 ? 30.963  -8.255  -20.196 1.00 50.72  ? 206 ASN A ND2 1 
ATOM   1582  N N   . LEU A 1 207 ? 29.089  -5.734  -16.442 1.00 56.21  ? 207 LEU A N   1 
ATOM   1583  C CA  . LEU A 1 207 ? 28.849  -5.648  -15.009 1.00 56.59  ? 207 LEU A CA  1 
ATOM   1584  C C   . LEU A 1 207 ? 28.973  -7.052  -14.449 1.00 49.64  ? 207 LEU A C   1 
ATOM   1585  O O   . LEU A 1 207 ? 28.376  -7.959  -15.013 1.00 46.07  ? 207 LEU A O   1 
ATOM   1586  C CB  . LEU A 1 207 ? 27.451  -5.109  -14.770 1.00 56.55  ? 207 LEU A CB  1 
ATOM   1587  C CG  . LEU A 1 207 ? 27.178  -3.726  -15.354 1.00 56.14  ? 207 LEU A CG  1 
ATOM   1588  C CD1 . LEU A 1 207 ? 25.713  -3.626  -15.753 1.00 62.10  ? 207 LEU A CD1 1 
ATOM   1589  C CD2 . LEU A 1 207 ? 27.530  -2.701  -14.308 1.00 59.88  ? 207 LEU A CD2 1 
ATOM   1590  N N   . TRP A 1 208 ? 29.742  -7.216  -13.366 1.00 48.37  ? 208 TRP A N   1 
ATOM   1591  C CA  . TRP A 1 208 ? 30.170  -8.539  -12.948 1.00 48.96  ? 208 TRP A CA  1 
ATOM   1592  C C   . TRP A 1 208 ? 28.957  -9.414  -12.666 1.00 52.18  ? 208 TRP A C   1 
ATOM   1593  O O   . TRP A 1 208 ? 27.987  -8.951  -12.082 1.00 59.30  ? 208 TRP A O   1 
ATOM   1594  C CB  . TRP A 1 208 ? 31.088  -8.484  -11.719 1.00 49.02  ? 208 TRP A CB  1 
ATOM   1595  C CG  . TRP A 1 208 ? 31.586  -9.847  -11.312 1.00 52.92  ? 208 TRP A CG  1 
ATOM   1596  C CD1 . TRP A 1 208 ? 32.617  -10.541 -11.866 1.00 60.37  ? 208 TRP A CD1 1 
ATOM   1597  C CD2 . TRP A 1 208 ? 31.042  -10.708 -10.289 1.00 59.41  ? 208 TRP A CD2 1 
ATOM   1598  N NE1 . TRP A 1 208 ? 32.773  -11.756 -11.252 1.00 61.34  ? 208 TRP A NE1 1 
ATOM   1599  C CE2 . TRP A 1 208 ? 31.819  -11.889 -10.285 1.00 60.14  ? 208 TRP A CE2 1 
ATOM   1600  C CE3 . TRP A 1 208 ? 29.977  -10.598 -9.385  1.00 62.01  ? 208 TRP A CE3 1 
ATOM   1601  C CZ2 . TRP A 1 208 ? 31.568  -12.946 -9.413  1.00 63.68  ? 208 TRP A CZ2 1 
ATOM   1602  C CZ3 . TRP A 1 208 ? 29.725  -11.646 -8.525  1.00 61.86  ? 208 TRP A CZ3 1 
ATOM   1603  C CH2 . TRP A 1 208 ? 30.507  -12.804 -8.544  1.00 62.37  ? 208 TRP A CH2 1 
ATOM   1604  N N   . ARG A 1 209 ? 29.049  -10.675 -13.088 1.00 58.40  ? 209 ARG A N   1 
ATOM   1605  C CA  . ARG A 1 209 ? 28.077  -11.695 -12.753 1.00 69.51  ? 209 ARG A CA  1 
ATOM   1606  C C   . ARG A 1 209 ? 28.847  -12.964 -12.410 1.00 65.31  ? 209 ARG A C   1 
ATOM   1607  O O   . ARG A 1 209 ? 29.928  -13.204 -12.926 1.00 67.49  ? 209 ARG A O   1 
ATOM   1608  C CB  . ARG A 1 209 ? 27.051  -11.840 -13.885 1.00 79.97  ? 209 ARG A CB  1 
ATOM   1609  C CG  . ARG A 1 209 ? 26.053  -10.683 -13.952 1.00 92.30  ? 209 ARG A CG  1 
ATOM   1610  C CD  . ARG A 1 209 ? 24.946  -10.642 -12.863 1.00 105.33 ? 209 ARG A CD  1 
ATOM   1611  N NE  . ARG A 1 209 ? 23.616  -11.041 -13.360 1.00 121.01 ? 209 ARG A NE  1 
ATOM   1612  C CZ  . ARG A 1 209 ? 22.903  -12.154 -13.094 1.00 116.18 ? 209 ARG A CZ  1 
ATOM   1613  N NH1 . ARG A 1 209 ? 23.321  -13.051 -12.214 1.00 116.69 ? 209 ARG A NH1 1 
ATOM   1614  N NH2 . ARG A 1 209 ? 21.755  -12.370 -13.720 1.00 100.97 ? 209 ARG A NH2 1 
ATOM   1615  N N   . PRO A 1 210 ? 28.359  -13.789 -11.466 1.00 68.15  ? 210 PRO A N   1 
ATOM   1616  C CA  . PRO A 1 210 ? 29.068  -15.011 -11.091 1.00 62.02  ? 210 PRO A CA  1 
ATOM   1617  C C   . PRO A 1 210 ? 29.424  -15.865 -12.299 1.00 58.21  ? 210 PRO A C   1 
ATOM   1618  O O   . PRO A 1 210 ? 28.551  -16.157 -13.100 1.00 60.53  ? 210 PRO A O   1 
ATOM   1619  C CB  . PRO A 1 210 ? 28.088  -15.748 -10.147 1.00 63.08  ? 210 PRO A CB  1 
ATOM   1620  C CG  . PRO A 1 210 ? 27.111  -14.691 -9.662  1.00 63.46  ? 210 PRO A CG  1 
ATOM   1621  C CD  . PRO A 1 210 ? 27.149  -13.546 -10.662 1.00 66.11  ? 210 PRO A CD  1 
ATOM   1622  N N   . GLY A 1 211 ? 30.696  -16.279 -12.403 1.00 63.90  ? 211 GLY A N   1 
ATOM   1623  C CA  . GLY A 1 211 ? 31.131  -17.225 -13.420 1.00 63.07  ? 211 GLY A CA  1 
ATOM   1624  C C   . GLY A 1 211 ? 31.809  -16.526 -14.596 1.00 67.92  ? 211 GLY A C   1 
ATOM   1625  O O   . GLY A 1 211 ? 32.383  -17.179 -15.471 1.00 74.60  ? 211 GLY A O   1 
ATOM   1626  N N   . GLN A 1 212 ? 31.738  -15.190 -14.610 1.00 60.16  ? 212 GLN A N   1 
ATOM   1627  C CA  . GLN A 1 212 ? 32.338  -14.417 -15.680 1.00 55.96  ? 212 GLN A CA  1 
ATOM   1628  C C   . GLN A 1 212 ? 33.828  -14.731 -15.762 1.00 54.77  ? 212 GLN A C   1 
ATOM   1629  O O   . GLN A 1 212 ? 34.517  -14.663 -14.754 1.00 52.44  ? 212 GLN A O   1 
ATOM   1630  C CB  . GLN A 1 212 ? 32.113  -12.931 -15.421 1.00 53.91  ? 212 GLN A CB  1 
ATOM   1631  C CG  . GLN A 1 212 ? 32.891  -12.006 -16.349 1.00 48.48  ? 212 GLN A CG  1 
ATOM   1632  C CD  . GLN A 1 212 ? 32.351  -10.599 -16.293 1.00 52.08  ? 212 GLN A CD  1 
ATOM   1633  O OE1 . GLN A 1 212 ? 31.172  -10.395 -15.990 1.00 59.33  ? 212 GLN A OE1 1 
ATOM   1634  N NE2 . GLN A 1 212 ? 33.189  -9.619  -16.593 1.00 51.21  ? 212 GLN A NE2 1 
ATOM   1635  N N   . THR A 1 213 ? 34.303  -15.024 -16.981 1.00 54.58  ? 213 THR A N   1 
ATOM   1636  C CA  . THR A 1 213 ? 35.689  -15.385 -17.230 1.00 49.81  ? 213 THR A CA  1 
ATOM   1637  C C   . THR A 1 213 ? 36.469  -14.153 -17.668 1.00 51.96  ? 213 THR A C   1 
ATOM   1638  O O   . THR A 1 213 ? 35.937  -13.056 -17.831 1.00 56.79  ? 213 THR A O   1 
ATOM   1639  C CB  . THR A 1 213 ? 35.751  -16.461 -18.309 1.00 46.27  ? 213 THR A CB  1 
ATOM   1640  O OG1 . THR A 1 213 ? 35.387  -15.743 -19.483 1.00 47.45  ? 213 THR A OG1 1 
ATOM   1641  C CG2 . THR A 1 213 ? 34.793  -17.614 -18.060 1.00 49.50  ? 213 THR A CG2 1 
ATOM   1642  N N   . SER A 1 214 ? 37.760  -14.374 -17.888 1.00 52.77  ? 214 SER A N   1 
ATOM   1643  C CA  . SER A 1 214 ? 38.686  -13.318 -18.239 1.00 48.08  ? 214 SER A CA  1 
ATOM   1644  C C   . SER A 1 214 ? 38.370  -12.831 -19.647 1.00 40.60  ? 214 SER A C   1 
ATOM   1645  O O   . SER A 1 214 ? 38.303  -11.634 -19.910 1.00 37.74  ? 214 SER A O   1 
ATOM   1646  C CB  . SER A 1 214 ? 40.117  -13.830 -18.134 1.00 47.64  ? 214 SER A CB  1 
ATOM   1647  O OG  . SER A 1 214 ? 41.038  -12.774 -18.354 1.00 47.96  ? 214 SER A OG  1 
ATOM   1648  N N   . ASP A 1 215 ? 38.166  -13.802 -20.532 1.00 39.43  ? 215 ASP A N   1 
ATOM   1649  C CA  . ASP A 1 215 ? 37.872  -13.555 -21.925 1.00 43.66  ? 215 ASP A CA  1 
ATOM   1650  C C   . ASP A 1 215 ? 36.515  -12.886 -22.115 1.00 47.45  ? 215 ASP A C   1 
ATOM   1651  O O   . ASP A 1 215 ? 36.315  -12.333 -23.195 1.00 43.93  ? 215 ASP A O   1 
ATOM   1652  C CB  . ASP A 1 215 ? 37.922  -14.837 -22.740 1.00 49.98  ? 215 ASP A CB  1 
ATOM   1653  C CG  . ASP A 1 215 ? 39.309  -15.368 -23.093 1.00 50.48  ? 215 ASP A CG  1 
ATOM   1654  O OD1 . ASP A 1 215 ? 40.291  -14.587 -23.003 1.00 45.44  ? 215 ASP A OD1 1 
ATOM   1655  O OD2 . ASP A 1 215 ? 39.385  -16.572 -23.436 1.00 45.25  ? 215 ASP A OD2 1 
ATOM   1656  N N   . GLN A 1 216 ? 35.611  -12.951 -21.105 1.00 47.42  ? 216 GLN A N   1 
ATOM   1657  C CA  . GLN A 1 216 ? 34.326  -12.263 -21.174 1.00 45.35  ? 216 GLN A CA  1 
ATOM   1658  C C   . GLN A 1 216 ? 34.442  -10.849 -20.618 1.00 44.78  ? 216 GLN A C   1 
ATOM   1659  O O   . GLN A 1 216 ? 33.462  -10.110 -20.608 1.00 49.10  ? 216 GLN A O   1 
ATOM   1660  C CB  . GLN A 1 216 ? 33.207  -12.981 -20.419 1.00 45.53  ? 216 GLN A CB  1 
ATOM   1661  C CG  . GLN A 1 216 ? 32.892  -14.358 -20.989 1.00 49.73  ? 216 GLN A CG  1 
ATOM   1662  C CD  . GLN A 1 216 ? 32.133  -15.285 -20.061 1.00 49.28  ? 216 GLN A CD  1 
ATOM   1663  O OE1 . GLN A 1 216 ? 31.727  -14.943 -18.950 1.00 53.91  ? 216 GLN A OE1 1 
ATOM   1664  N NE2 . GLN A 1 216 ? 31.930  -16.501 -20.530 1.00 55.29  ? 216 GLN A NE2 1 
ATOM   1665  N N   . THR A 1 217 ? 35.613  -10.455 -20.122 1.00 40.30  ? 217 THR A N   1 
ATOM   1666  C CA  . THR A 1 217 ? 35.721  -9.100  -19.596 1.00 43.12  ? 217 THR A CA  1 
ATOM   1667  C C   . THR A 1 217 ? 36.319  -8.174  -20.659 1.00 43.61  ? 217 THR A C   1 
ATOM   1668  O O   . THR A 1 217 ? 37.520  -8.207  -20.907 1.00 43.55  ? 217 THR A O   1 
ATOM   1669  C CB  . THR A 1 217 ? 36.511  -9.111  -18.290 1.00 41.93  ? 217 THR A CB  1 
ATOM   1670  O OG1 . THR A 1 217 ? 35.921  -10.133 -17.490 1.00 42.81  ? 217 THR A OG1 1 
ATOM   1671  C CG2 . THR A 1 217 ? 36.429  -7.791  -17.546 1.00 42.56  ? 217 THR A CG2 1 
ATOM   1672  N N   . VAL A 1 218 ? 35.468  -7.338  -21.277 1.00 45.44  ? 218 VAL A N   1 
ATOM   1673  C CA  . VAL A 1 218 ? 35.885  -6.439  -22.342 1.00 43.03  ? 218 VAL A CA  1 
ATOM   1674  C C   . VAL A 1 218 ? 35.247  -5.076  -22.186 1.00 41.95  ? 218 VAL A C   1 
ATOM   1675  O O   . VAL A 1 218 ? 34.023  -4.992  -22.228 1.00 46.63  ? 218 VAL A O   1 
ATOM   1676  C CB  . VAL A 1 218 ? 35.421  -6.999  -23.684 1.00 45.83  ? 218 VAL A CB  1 
ATOM   1677  C CG1 . VAL A 1 218 ? 35.963  -6.161  -24.832 1.00 43.89  ? 218 VAL A CG1 1 
ATOM   1678  C CG2 . VAL A 1 218 ? 35.774  -8.470  -23.815 1.00 53.00  ? 218 VAL A CG2 1 
ATOM   1679  N N   . TYR A 1 219 ? 36.073  -4.026  -22.110 1.00 39.80  ? 219 TYR A N   1 
ATOM   1680  C CA  . TYR A 1 219 ? 35.613  -2.650  -22.201 1.00 40.73  ? 219 TYR A CA  1 
ATOM   1681  C C   . TYR A 1 219 ? 36.276  -1.985  -23.400 1.00 41.67  ? 219 TYR A C   1 
ATOM   1682  O O   . TYR A 1 219 ? 37.498  -1.960  -23.455 1.00 42.50  ? 219 TYR A O   1 
ATOM   1683  C CB  . TYR A 1 219 ? 35.988  -1.914  -20.919 1.00 38.10  ? 219 TYR A CB  1 
ATOM   1684  C CG  . TYR A 1 219 ? 35.365  -2.558  -19.696 1.00 44.40  ? 219 TYR A CG  1 
ATOM   1685  C CD1 . TYR A 1 219 ? 35.889  -3.722  -19.147 1.00 43.09  ? 219 TYR A CD1 1 
ATOM   1686  C CD2 . TYR A 1 219 ? 34.215  -2.023  -19.125 1.00 40.43  ? 219 TYR A CD2 1 
ATOM   1687  C CE1 . TYR A 1 219 ? 35.311  -4.315  -18.036 1.00 40.30  ? 219 TYR A CE1 1 
ATOM   1688  C CE2 . TYR A 1 219 ? 33.628  -2.609  -18.023 1.00 38.40  ? 219 TYR A CE2 1 
ATOM   1689  C CZ  . TYR A 1 219 ? 34.166  -3.760  -17.488 1.00 42.01  ? 219 TYR A CZ  1 
ATOM   1690  O OH  . TYR A 1 219 ? 33.546  -4.305  -16.406 1.00 40.03  ? 219 TYR A OH  1 
ATOM   1691  N N   . ALA A 1 220 ? 35.492  -1.431  -24.333 1.00 36.38  ? 220 ALA A N   1 
ATOM   1692  C CA  . ALA A 1 220 ? 36.075  -0.925  -25.568 1.00 39.26  ? 220 ALA A CA  1 
ATOM   1693  C C   . ALA A 1 220 ? 35.108  -0.022  -26.306 1.00 36.95  ? 220 ALA A C   1 
ATOM   1694  O O   . ALA A 1 220 ? 33.912  -0.225  -26.204 1.00 40.87  ? 220 ALA A O   1 
ATOM   1695  C CB  . ALA A 1 220 ? 36.456  -2.083  -26.454 1.00 38.94  ? 220 ALA A CB  1 
ATOM   1696  N N   . ILE A 1 221 ? 35.641  0.953   -27.048 1.00 39.56  ? 221 ILE A N   1 
ATOM   1697  C CA  . ILE A 1 221 ? 34.864  1.702   -28.018 1.00 40.41  ? 221 ILE A CA  1 
ATOM   1698  C C   . ILE A 1 221 ? 34.862  0.926   -29.329 1.00 39.89  ? 221 ILE A C   1 
ATOM   1699  O O   . ILE A 1 221 ? 35.893  0.414   -29.730 1.00 46.18  ? 221 ILE A O   1 
ATOM   1700  C CB  . ILE A 1 221 ? 35.432  3.101   -28.238 1.00 47.83  ? 221 ILE A CB  1 
ATOM   1701  C CG1 . ILE A 1 221 ? 35.481  3.869   -26.967 1.00 55.28  ? 221 ILE A CG1 1 
ATOM   1702  C CG2 . ILE A 1 221 ? 34.621  3.839   -29.294 1.00 56.11  ? 221 ILE A CG2 1 
ATOM   1703  C CD1 . ILE A 1 221 ? 35.847  5.327   -27.136 1.00 59.06  ? 221 ILE A CD1 1 
ATOM   1704  N N   . VAL A 1 222 ? 33.691  0.810   -29.954 1.00 34.13  ? 222 VAL A N   1 
ATOM   1705  C CA  . VAL A 1 222 ? 33.516  0.055   -31.180 1.00 33.45  ? 222 VAL A CA  1 
ATOM   1706  C C   . VAL A 1 222 ? 32.598  0.811   -32.147 1.00 37.17  ? 222 VAL A C   1 
ATOM   1707  O O   . VAL A 1 222 ? 31.409  1.001   -31.902 1.00 37.66  ? 222 VAL A O   1 
ATOM   1708  C CB  . VAL A 1 222 ? 32.923  -1.330  -30.933 1.00 32.86  ? 222 VAL A CB  1 
ATOM   1709  C CG1 . VAL A 1 222 ? 32.713  -2.060  -32.246 1.00 33.83  ? 222 VAL A CG1 1 
ATOM   1710  C CG2 . VAL A 1 222 ? 33.777  -2.148  -30.006 1.00 37.58  ? 222 VAL A CG2 1 
ATOM   1711  N N   . PRO A 1 223 ? 33.094  1.240   -33.316 1.00 35.71  ? 223 PRO A N   1 
ATOM   1712  C CA  . PRO A 1 223 ? 32.239  1.980   -34.243 1.00 35.80  ? 223 PRO A CA  1 
ATOM   1713  C C   . PRO A 1 223 ? 31.015  1.182   -34.654 1.00 35.19  ? 223 PRO A C   1 
ATOM   1714  O O   . PRO A 1 223 ? 31.144  -0.008  -34.853 1.00 33.60  ? 223 PRO A O   1 
ATOM   1715  C CB  . PRO A 1 223 ? 33.191  2.238   -35.407 1.00 36.05  ? 223 PRO A CB  1 
ATOM   1716  C CG  . PRO A 1 223 ? 34.569  2.304   -34.765 1.00 39.71  ? 223 PRO A CG  1 
ATOM   1717  C CD  . PRO A 1 223 ? 34.502  1.151   -33.746 1.00 36.94  ? 223 PRO A CD  1 
ATOM   1718  N N   . VAL A 1 224 ? 29.859  1.839   -34.861 1.00 35.69  ? 224 VAL A N   1 
ATOM   1719  C CA  . VAL A 1 224 ? 28.634  1.100   -35.141 1.00 37.95  ? 224 VAL A CA  1 
ATOM   1720  C C   . VAL A 1 224 ? 28.712  0.400   -36.499 1.00 38.60  ? 224 VAL A C   1 
ATOM   1721  O O   . VAL A 1 224 ? 28.088  -0.638  -36.657 1.00 39.54  ? 224 VAL A O   1 
ATOM   1722  C CB  . VAL A 1 224 ? 27.324  1.906   -35.016 1.00 41.91  ? 224 VAL A CB  1 
ATOM   1723  C CG1 . VAL A 1 224 ? 26.113  1.174   -35.583 1.00 48.14  ? 224 VAL A CG1 1 
ATOM   1724  C CG2 . VAL A 1 224 ? 27.019  2.242   -33.569 1.00 40.77  ? 224 VAL A CG2 1 
ATOM   1725  N N   . ASN A 1 225 ? 29.478  0.916   -37.469 1.00 42.97  ? 225 ASN A N   1 
ATOM   1726  C CA  . ASN A 1 225 ? 29.569  0.259   -38.767 1.00 44.56  ? 225 ASN A CA  1 
ATOM   1727  C C   . ASN A 1 225 ? 30.800  -0.627  -38.911 1.00 46.13  ? 225 ASN A C   1 
ATOM   1728  O O   . ASN A 1 225 ? 31.261  -0.867  -40.013 1.00 51.05  ? 225 ASN A O   1 
ATOM   1729  C CB  . ASN A 1 225 ? 29.612  1.252   -39.907 1.00 46.47  ? 225 ASN A CB  1 
ATOM   1730  C CG  . ASN A 1 225 ? 30.838  2.114   -39.837 1.00 45.69  ? 225 ASN A CG  1 
ATOM   1731  O OD1 . ASN A 1 225 ? 31.506  2.149   -38.798 1.00 44.71  ? 225 ASN A OD1 1 
ATOM   1732  N ND2 . ASN A 1 225 ? 31.089  2.856   -40.907 1.00 42.37  ? 225 ASN A ND2 1 
ATOM   1733  N N   . THR A 1 226 ? 31.313  -1.149  -37.808 1.00 46.20  ? 226 THR A N   1 
ATOM   1734  C CA  . THR A 1 226 ? 32.429  -2.064  -37.880 1.00 42.51  ? 226 THR A CA  1 
ATOM   1735  C C   . THR A 1 226 ? 31.970  -3.329  -38.591 1.00 39.02  ? 226 THR A C   1 
ATOM   1736  O O   . THR A 1 226 ? 30.875  -3.805  -38.338 1.00 39.99  ? 226 THR A O   1 
ATOM   1737  C CB  . THR A 1 226 ? 32.930  -2.390  -36.478 1.00 40.80  ? 226 THR A CB  1 
ATOM   1738  O OG1 . THR A 1 226 ? 33.293  -1.162  -35.867 1.00 48.32  ? 226 THR A OG1 1 
ATOM   1739  C CG2 . THR A 1 226 ? 34.140  -3.298  -36.509 1.00 43.87  ? 226 THR A CG2 1 
ATOM   1740  N N   . PRO A 1 227 ? 32.800  -3.915  -39.480 1.00 43.57  ? 227 PRO A N   1 
ATOM   1741  C CA  . PRO A 1 227 ? 32.480  -5.188  -40.125 1.00 44.34  ? 227 PRO A CA  1 
ATOM   1742  C C   . PRO A 1 227 ? 32.163  -6.274  -39.111 1.00 41.46  ? 227 PRO A C   1 
ATOM   1743  O O   . PRO A 1 227 ? 32.953  -6.504  -38.200 1.00 44.42  ? 227 PRO A O   1 
ATOM   1744  C CB  . PRO A 1 227 ? 33.753  -5.506  -40.912 1.00 39.37  ? 227 PRO A CB  1 
ATOM   1745  C CG  . PRO A 1 227 ? 34.295  -4.134  -41.233 1.00 40.65  ? 227 PRO A CG  1 
ATOM   1746  C CD  . PRO A 1 227 ? 34.071  -3.351  -39.967 1.00 43.50  ? 227 PRO A CD  1 
ATOM   1747  N N   . GLY A 1 228 ? 31.009  -6.917  -39.296 1.00 38.68  ? 228 GLY A N   1 
ATOM   1748  C CA  . GLY A 1 228 ? 30.609  -8.063  -38.495 1.00 38.66  ? 228 GLY A CA  1 
ATOM   1749  C C   . GLY A 1 228 ? 29.659  -7.705  -37.346 1.00 35.01  ? 228 GLY A C   1 
ATOM   1750  O O   . GLY A 1 228 ? 29.172  -8.617  -36.674 1.00 35.46  ? 228 GLY A O   1 
ATOM   1751  N N   . LEU A 1 229 ? 29.460  -6.402  -37.095 1.00 36.40  ? 229 LEU A N   1 
ATOM   1752  C CA  . LEU A 1 229 ? 28.553  -5.925  -36.052 1.00 37.74  ? 229 LEU A CA  1 
ATOM   1753  C C   . LEU A 1 229 ? 27.133  -5.745  -36.583 1.00 33.87  ? 229 LEU A C   1 
ATOM   1754  O O   . LEU A 1 229 ? 26.910  -4.979  -37.497 1.00 31.05  ? 229 LEU A O   1 
ATOM   1755  C CB  . LEU A 1 229 ? 29.062  -4.596  -35.508 1.00 38.37  ? 229 LEU A CB  1 
ATOM   1756  C CG  . LEU A 1 229 ? 28.214  -3.984  -34.389 1.00 42.06  ? 229 LEU A CG  1 
ATOM   1757  C CD1 . LEU A 1 229 ? 28.089  -4.947  -33.211 1.00 46.13  ? 229 LEU A CD1 1 
ATOM   1758  C CD2 . LEU A 1 229 ? 28.784  -2.674  -33.913 1.00 41.97  ? 229 LEU A CD2 1 
ATOM   1759  N N   . SER A 1 230 ? 26.169  -6.461  -36.015 1.00 38.63  ? 230 SER A N   1 
ATOM   1760  C CA  . SER A 1 230 ? 24.764  -6.314  -36.379 1.00 35.47  ? 230 SER A CA  1 
ATOM   1761  C C   . SER A 1 230 ? 23.979  -5.790  -35.181 1.00 35.37  ? 230 SER A C   1 
ATOM   1762  O O   . SER A 1 230 ? 24.060  -6.370  -34.098 1.00 35.59  ? 230 SER A O   1 
ATOM   1763  C CB  . SER A 1 230 ? 24.188  -7.624  -36.806 1.00 35.28  ? 230 SER A CB  1 
ATOM   1764  O OG  . SER A 1 230 ? 24.724  -8.042  -38.053 1.00 37.76  ? 230 SER A OG  1 
ATOM   1765  N N   . LEU A 1 231 ? 23.243  -4.699  -35.395 1.00 32.60  ? 231 LEU A N   1 
ATOM   1766  C CA  . LEU A 1 231 ? 22.327  -4.140  -34.424 1.00 32.13  ? 231 LEU A CA  1 
ATOM   1767  C C   . LEU A 1 231 ? 20.943  -4.760  -34.609 1.00 34.92  ? 231 LEU A C   1 
ATOM   1768  O O   . LEU A 1 231 ? 20.311  -4.551  -35.644 1.00 34.37  ? 231 LEU A O   1 
ATOM   1769  C CB  . LEU A 1 231 ? 22.301  -2.640  -34.687 1.00 35.14  ? 231 LEU A CB  1 
ATOM   1770  C CG  . LEU A 1 231 ? 23.277  -1.781  -33.890 1.00 41.14  ? 231 LEU A CG  1 
ATOM   1771  C CD1 . LEU A 1 231 ? 24.637  -2.354  -33.794 1.00 44.20  ? 231 LEU A CD1 1 
ATOM   1772  C CD2 . LEU A 1 231 ? 23.333  -0.392  -34.476 1.00 50.31  ? 231 LEU A CD2 1 
ATOM   1773  N N   . VAL A 1 232 ? 20.470  -5.517  -33.607 1.00 33.54  ? 232 VAL A N   1 
ATOM   1774  C CA  . VAL A 1 232 ? 19.168  -6.158  -33.683 1.00 33.26  ? 232 VAL A CA  1 
ATOM   1775  C C   . VAL A 1 232 ? 18.199  -5.425  -32.756 1.00 33.85  ? 232 VAL A C   1 
ATOM   1776  O O   . VAL A 1 232 ? 18.159  -5.678  -31.549 1.00 32.71  ? 232 VAL A O   1 
ATOM   1777  C CB  . VAL A 1 232 ? 19.312  -7.644  -33.319 1.00 34.48  ? 232 VAL A CB  1 
ATOM   1778  C CG1 . VAL A 1 232 ? 18.005  -8.396  -33.428 1.00 33.10  ? 232 VAL A CG1 1 
ATOM   1779  C CG2 . VAL A 1 232 ? 20.350  -8.311  -34.193 1.00 34.67  ? 232 VAL A CG2 1 
ATOM   1780  N N   . CYS A 1 233 ? 17.422  -4.503  -33.333 1.00 31.38  ? 233 CYS A N   1 
ATOM   1781  C CA  . CYS A 1 233 ? 16.546  -3.664  -32.544 1.00 33.90  ? 233 CYS A CA  1 
ATOM   1782  C C   . CYS A 1 233 ? 15.103  -4.156  -32.566 1.00 32.04  ? 233 CYS A C   1 
ATOM   1783  O O   . CYS A 1 233 ? 14.682  -4.784  -33.515 1.00 33.30  ? 233 CYS A O   1 
ATOM   1784  C CB  . CYS A 1 233 ? 16.528  -2.238  -33.070 1.00 31.92  ? 233 CYS A CB  1 
ATOM   1785  S SG  . CYS A 1 233 ? 18.182  -1.535  -33.046 1.00 36.32  ? 233 CYS A SG  1 
ATOM   1786  N N   . ARG A 1 234 ? 14.351  -3.735  -31.547 1.00 29.78  ? 234 ARG A N   1 
ATOM   1787  C CA  . ARG A 1 234 ? 12.925  -3.977  -31.406 1.00 27.87  ? 234 ARG A CA  1 
ATOM   1788  C C   . ARG A 1 234 ? 12.173  -3.287  -32.531 1.00 29.64  ? 234 ARG A C   1 
ATOM   1789  O O   . ARG A 1 234 ? 12.667  -2.339  -33.113 1.00 35.94  ? 234 ARG A O   1 
ATOM   1790  C CB  . ARG A 1 234 ? 12.476  -3.499  -30.012 1.00 26.82  ? 234 ARG A CB  1 
ATOM   1791  C CG  . ARG A 1 234 ? 12.463  -1.987  -29.811 1.00 28.83  ? 234 ARG A CG  1 
ATOM   1792  C CD  . ARG A 1 234 ? 11.884  -1.628  -28.465 1.00 29.97  ? 234 ARG A CD  1 
ATOM   1793  N NE  . ARG A 1 234 ? 12.019  -0.198  -28.156 1.00 29.32  ? 234 ARG A NE  1 
ATOM   1794  C CZ  . ARG A 1 234 ? 11.341  0.802   -28.708 1.00 29.75  ? 234 ARG A CZ  1 
ATOM   1795  N NH1 . ARG A 1 234 ? 10.420  0.591   -29.629 1.00 35.96  ? 234 ARG A NH1 1 
ATOM   1796  N NH2 . ARG A 1 234 ? 11.594  2.047   -28.357 1.00 29.50  ? 234 ARG A NH2 1 
ATOM   1797  N N   . GLN A 1 235 ? 10.916  -3.684  -32.749 1.00 31.11  ? 235 GLN A N   1 
ATOM   1798  C CA  . GLN A 1 235 ? 10.105  -3.030  -33.754 1.00 28.87  ? 235 GLN A CA  1 
ATOM   1799  C C   . GLN A 1 235 ? 9.926   -1.551  -33.407 1.00 27.90  ? 235 GLN A C   1 
ATOM   1800  O O   . GLN A 1 235 ? 9.860   -1.173  -32.244 1.00 30.43  ? 235 GLN A O   1 
ATOM   1801  C CB  . GLN A 1 235 ? 8.750   -3.740  -33.774 1.00 30.33  ? 235 GLN A CB  1 
ATOM   1802  C CG  . GLN A 1 235 ? 7.788   -3.153  -34.797 1.00 31.09  ? 235 GLN A CG  1 
ATOM   1803  C CD  . GLN A 1 235 ? 8.345   -3.268  -36.195 1.00 32.91  ? 235 GLN A CD  1 
ATOM   1804  O OE1 . GLN A 1 235 ? 9.152   -2.466  -36.644 1.00 33.07  ? 235 GLN A OE1 1 
ATOM   1805  N NE2 . GLN A 1 235 ? 7.950   -4.309  -36.901 1.00 35.88  ? 235 GLN A NE2 1 
ATOM   1806  N N   . SER A 1 236 ? 9.765   -0.712  -34.422 1.00 29.32  ? 236 SER A N   1 
ATOM   1807  C CA  . SER A 1 236 ? 9.476   0.687   -34.190 1.00 29.00  ? 236 SER A CA  1 
ATOM   1808  C C   . SER A 1 236 ? 7.988   0.871   -33.899 1.00 36.20  ? 236 SER A C   1 
ATOM   1809  O O   . SER A 1 236 ? 7.136   0.257   -34.516 1.00 33.57  ? 236 SER A O   1 
ATOM   1810  C CB  . SER A 1 236 ? 9.883   1.510   -35.348 1.00 30.15  ? 236 SER A CB  1 
ATOM   1811  O OG  . SER A 1 236 ? 9.604   2.882   -35.124 1.00 30.92  ? 236 SER A OG  1 
ATOM   1812  N N   . ASN A 1 237 ? 7.697   1.730   -32.927 1.00 37.67  ? 237 ASN A N   1 
ATOM   1813  C CA  . ASN A 1 237 ? 6.355   2.132   -32.630 1.00 32.98  ? 237 ASN A CA  1 
ATOM   1814  C C   . ASN A 1 237 ? 6.178   3.545   -33.158 1.00 34.40  ? 237 ASN A C   1 
ATOM   1815  O O   . ASN A 1 237 ? 5.193   4.194   -32.855 1.00 32.19  ? 237 ASN A O   1 
ATOM   1816  C CB  . ASN A 1 237 ? 6.119   2.058   -31.136 1.00 34.45  ? 237 ASN A CB  1 
ATOM   1817  C CG  . ASN A 1 237 ? 6.229   0.644   -30.621 1.00 29.30  ? 237 ASN A CG  1 
ATOM   1818  O OD1 . ASN A 1 237 ? 5.534   -0.237  -31.103 1.00 33.63  ? 237 ASN A OD1 1 
ATOM   1819  N ND2 . ASN A 1 237 ? 7.051   0.400   -29.626 1.00 27.18  ? 237 ASN A ND2 1 
ATOM   1820  N N   . ALA A 1 238 ? 7.111   4.033   -33.975 1.00 34.02  ? 238 ALA A N   1 
ATOM   1821  C CA  . ALA A 1 238 ? 6.904   5.348   -34.569 1.00 38.70  ? 238 ALA A CA  1 
ATOM   1822  C C   . ALA A 1 238 ? 5.692   5.334   -35.512 1.00 38.65  ? 238 ALA A C   1 
ATOM   1823  O O   . ALA A 1 238 ? 5.393   4.327   -36.163 1.00 36.51  ? 238 ALA A O   1 
ATOM   1824  C CB  . ALA A 1 238 ? 8.145   5.765   -35.289 1.00 37.50  ? 238 ALA A CB  1 
ATOM   1825  N N   . THR A 1 239 ? 4.986   6.456   -35.585 1.00 35.02  ? 239 THR A N   1 
ATOM   1826  C CA  . THR A 1 239 ? 3.833   6.563   -36.476 1.00 36.04  ? 239 THR A CA  1 
ATOM   1827  C C   . THR A 1 239 ? 3.965   7.849   -37.274 1.00 37.39  ? 239 THR A C   1 
ATOM   1828  O O   . THR A 1 239 ? 3.133   8.739   -37.135 1.00 40.33  ? 239 THR A O   1 
ATOM   1829  C CB  . THR A 1 239 ? 2.497   6.533   -35.727 1.00 31.68  ? 239 THR A CB  1 
ATOM   1830  O OG1 . THR A 1 239 ? 2.436   7.580   -34.755 1.00 30.57  ? 239 THR A OG1 1 
ATOM   1831  C CG2 . THR A 1 239 ? 2.287   5.234   -34.982 1.00 30.21  ? 239 THR A CG2 1 
ATOM   1832  N N   . PRO A 1 240 ? 4.956   7.926   -38.188 1.00 39.67  ? 240 PRO A N   1 
ATOM   1833  C CA  . PRO A 1 240 ? 5.212   9.141   -38.969 1.00 41.80  ? 240 PRO A CA  1 
ATOM   1834  C C   . PRO A 1 240 ? 4.046   9.603   -39.842 1.00 40.25  ? 240 PRO A C   1 
ATOM   1835  O O   . PRO A 1 240 ? 4.006   10.760  -40.213 1.00 45.12  ? 240 PRO A O   1 
ATOM   1836  C CB  . PRO A 1 240 ? 6.427   8.766   -39.840 1.00 39.16  ? 240 PRO A CB  1 
ATOM   1837  C CG  . PRO A 1 240 ? 6.267   7.254   -40.005 1.00 43.73  ? 240 PRO A CG  1 
ATOM   1838  C CD  . PRO A 1 240 ? 5.782   6.787   -38.630 1.00 42.72  ? 240 PRO A CD  1 
ATOM   1839  N N   . ASP A 1 241 ? 3.107   8.714   -40.175 1.00 45.13  ? 241 ASP A N   1 
ATOM   1840  C CA  . ASP A 1 241 ? 1.989   9.094   -41.028 1.00 51.78  ? 241 ASP A CA  1 
ATOM   1841  C C   . ASP A 1 241 ? 0.703   9.331   -40.239 1.00 52.43  ? 241 ASP A C   1 
ATOM   1842  O O   . ASP A 1 241 ? -0.284  9.758   -40.813 1.00 49.43  ? 241 ASP A O   1 
ATOM   1843  C CB  . ASP A 1 241 ? 1.649   8.012   -42.043 1.00 58.35  ? 241 ASP A CB  1 
ATOM   1844  C CG  . ASP A 1 241 ? 2.710   7.715   -43.090 1.00 63.26  ? 241 ASP A CG  1 
ATOM   1845  O OD1 . ASP A 1 241 ? 3.394   8.682   -43.530 1.00 59.36  ? 241 ASP A OD1 1 
ATOM   1846  O OD2 . ASP A 1 241 ? 2.803   6.528   -43.479 1.00 64.27  ? 241 ASP A OD2 1 
ATOM   1847  N N   . ALA A 1 242 ? 0.659   9.011   -38.944 1.00 45.78  ? 242 ALA A N   1 
ATOM   1848  C CA  . ALA A 1 242 ? -0.540  9.312   -38.197 1.00 40.93  ? 242 ALA A CA  1 
ATOM   1849  C C   . ALA A 1 242 ? -0.714  10.834  -38.128 1.00 47.86  ? 242 ALA A C   1 
ATOM   1850  O O   . ALA A 1 242 ? 0.221   11.583  -38.437 1.00 41.78  ? 242 ALA A O   1 
ATOM   1851  C CB  . ALA A 1 242 ? -0.474  8.666   -36.845 1.00 38.83  ? 242 ALA A CB  1 
ATOM   1852  N N   . ASP A 1 243 ? -1.948  11.267  -37.811 1.00 44.69  ? 243 ASP A N   1 
ATOM   1853  C CA  . ASP A 1 243 ? -2.247  12.645  -37.472 1.00 43.53  ? 243 ASP A CA  1 
ATOM   1854  C C   . ASP A 1 243 ? -1.741  12.981  -36.064 1.00 45.72  ? 243 ASP A C   1 
ATOM   1855  O O   . ASP A 1 243 ? -2.060  12.310  -35.078 1.00 38.57  ? 243 ASP A O   1 
ATOM   1856  C CB  . ASP A 1 243 ? -3.739  12.938  -37.525 1.00 46.66  ? 243 ASP A CB  1 
ATOM   1857  C CG  . ASP A 1 243 ? -4.067  14.425  -37.535 1.00 47.83  ? 243 ASP A CG  1 
ATOM   1858  O OD1 . ASP A 1 243 ? -3.571  15.145  -36.633 1.00 43.93  ? 243 ASP A OD1 1 
ATOM   1859  O OD2 . ASP A 1 243 ? -4.779  14.858  -38.470 1.00 56.54  ? 243 ASP A OD2 1 
ATOM   1860  N N   . PRO A 1 244 ? -0.988  14.090  -35.926 1.00 42.11  ? 244 PRO A N   1 
ATOM   1861  C CA  . PRO A 1 244 ? -0.479  14.529  -34.630 1.00 36.62  ? 244 PRO A CA  1 
ATOM   1862  C C   . PRO A 1 244 ? -1.528  14.754  -33.552 1.00 37.24  ? 244 PRO A C   1 
ATOM   1863  O O   . PRO A 1 244 ? -1.229  14.627  -32.368 1.00 39.44  ? 244 PRO A O   1 
ATOM   1864  C CB  . PRO A 1 244 ? 0.219   15.842  -34.968 1.00 43.79  ? 244 PRO A CB  1 
ATOM   1865  C CG  . PRO A 1 244 ? 0.568   15.732  -36.429 1.00 42.52  ? 244 PRO A CG  1 
ATOM   1866  C CD  . PRO A 1 244 ? -0.559  14.945  -37.044 1.00 41.08  ? 244 PRO A CD  1 
ATOM   1867  N N   . TYR A 1 245 ? -2.754  15.111  -33.940 1.00 37.56  ? 245 TYR A N   1 
ATOM   1868  C CA  . TYR A 1 245 ? -3.824  15.256  -32.956 1.00 31.85  ? 245 TYR A CA  1 
ATOM   1869  C C   . TYR A 1 245 ? -4.127  13.897  -32.333 1.00 32.26  ? 245 TYR A C   1 
ATOM   1870  O O   . TYR A 1 245 ? -4.338  13.798  -31.132 1.00 34.41  ? 245 TYR A O   1 
ATOM   1871  C CB  . TYR A 1 245 ? -5.082  15.889  -33.552 1.00 32.19  ? 245 TYR A CB  1 
ATOM   1872  C CG  . TYR A 1 245 ? -6.154  16.085  -32.511 1.00 31.91  ? 245 TYR A CG  1 
ATOM   1873  C CD1 . TYR A 1 245 ? -7.049  15.075  -32.253 1.00 31.45  ? 245 TYR A CD1 1 
ATOM   1874  C CD2 . TYR A 1 245 ? -6.246  17.242  -31.761 1.00 31.28  ? 245 TYR A CD2 1 
ATOM   1875  C CE1 . TYR A 1 245 ? -8.021  15.202  -31.285 1.00 32.37  ? 245 TYR A CE1 1 
ATOM   1876  C CE2 . TYR A 1 245 ? -7.209  17.370  -30.775 1.00 30.35  ? 245 TYR A CE2 1 
ATOM   1877  C CZ  . TYR A 1 245 ? -8.105  16.349  -30.534 1.00 31.82  ? 245 TYR A CZ  1 
ATOM   1878  O OH  . TYR A 1 245 ? -9.105  16.383  -29.588 1.00 33.49  ? 245 TYR A OH  1 
ATOM   1879  N N   . ASP A 1 246 ? -4.151  12.850  -33.152 1.00 33.31  ? 246 ASP A N   1 
ATOM   1880  C CA  . ASP A 1 246 ? -4.440  11.498  -32.708 1.00 35.68  ? 246 ASP A CA  1 
ATOM   1881  C C   . ASP A 1 246 ? -3.288  10.909  -31.887 1.00 40.85  ? 246 ASP A C   1 
ATOM   1882  O O   . ASP A 1 246 ? -3.519  10.317  -30.832 1.00 37.56  ? 246 ASP A O   1 
ATOM   1883  C CB  . ASP A 1 246 ? -4.744  10.613  -33.915 1.00 37.71  ? 246 ASP A CB  1 
ATOM   1884  C CG  . ASP A 1 246 ? -5.941  11.020  -34.771 1.00 37.67  ? 246 ASP A CG  1 
ATOM   1885  O OD1 . ASP A 1 246 ? -6.765  11.782  -34.261 1.00 38.56  ? 246 ASP A OD1 1 
ATOM   1886  O OD2 . ASP A 1 246 ? -6.015  10.619  -35.959 1.00 41.57  ? 246 ASP A OD2 1 
ATOM   1887  N N   . HIS A 1 247 ? -2.052  11.048  -32.396 1.00 40.17  ? 247 HIS A N   1 
ATOM   1888  C CA  . HIS A 1 247 ? -0.870  10.470  -31.774 1.00 42.38  ? 247 HIS A CA  1 
ATOM   1889  C C   . HIS A 1 247 ? 0.203   11.554  -31.686 1.00 37.67  ? 247 HIS A C   1 
ATOM   1890  O O   . HIS A 1 247 ? 1.027   11.662  -32.574 1.00 37.02  ? 247 HIS A O   1 
ATOM   1891  C CB  . HIS A 1 247 ? -0.461  9.201   -32.535 1.00 45.86  ? 247 HIS A CB  1 
ATOM   1892  C CG  . HIS A 1 247 ? -1.389  8.046   -32.285 1.00 55.33  ? 247 HIS A CG  1 
ATOM   1893  N ND1 . HIS A 1 247 ? -1.676  7.598   -31.008 1.00 64.72  ? 247 HIS A ND1 1 
ATOM   1894  C CD2 . HIS A 1 247 ? -2.113  7.279   -33.111 1.00 46.09  ? 247 HIS A CD2 1 
ATOM   1895  C CE1 . HIS A 1 247 ? -2.551  6.601   -31.069 1.00 56.83  ? 247 HIS A CE1 1 
ATOM   1896  N NE2 . HIS A 1 247 ? -2.820  6.391   -32.340 1.00 57.43  ? 247 HIS A NE2 1 
ATOM   1897  N N   . PRO A 1 248 ? 0.181   12.432  -30.654 1.00 37.01  ? 248 PRO A N   1 
ATOM   1898  C CA  . PRO A 1 248 ? 1.067   13.593  -30.585 1.00 33.87  ? 248 PRO A CA  1 
ATOM   1899  C C   . PRO A 1 248 ? 2.518   13.255  -30.342 1.00 33.84  ? 248 PRO A C   1 
ATOM   1900  O O   . PRO A 1 248 ? 3.358   14.139  -30.476 1.00 36.80  ? 248 PRO A O   1 
ATOM   1901  C CB  . PRO A 1 248 ? 0.526   14.403  -29.388 1.00 33.90  ? 248 PRO A CB  1 
ATOM   1902  C CG  . PRO A 1 248 ? -0.086  13.339  -28.519 1.00 36.43  ? 248 PRO A CG  1 
ATOM   1903  C CD  . PRO A 1 248 ? -0.738  12.388  -29.504 1.00 37.11  ? 248 PRO A CD  1 
ATOM   1904  N N   . LEU A 1 249 ? 2.788   12.037  -29.872 1.00 32.25  ? 249 LEU A N   1 
ATOM   1905  C CA  . LEU A 1 249 ? 4.147   11.728  -29.473 1.00 31.25  ? 249 LEU A CA  1 
ATOM   1906  C C   . LEU A 1 249 ? 4.742   10.692  -30.419 1.00 33.17  ? 249 LEU A C   1 
ATOM   1907  O O   . LEU A 1 249 ? 5.877   10.861  -30.877 1.00 35.70  ? 249 LEU A O   1 
ATOM   1908  C CB  . LEU A 1 249 ? 4.228   11.288  -28.021 1.00 33.10  ? 249 LEU A CB  1 
ATOM   1909  C CG  . LEU A 1 249 ? 3.748   12.294  -26.970 1.00 35.62  ? 249 LEU A CG  1 
ATOM   1910  C CD1 . LEU A 1 249 ? 3.881   11.683  -25.598 1.00 38.84  ? 249 LEU A CD1 1 
ATOM   1911  C CD2 . LEU A 1 249 ? 4.457   13.649  -27.006 1.00 36.80  ? 249 LEU A CD2 1 
ATOM   1912  N N   . SER A 1 250 ? 3.980   9.650   -30.753 1.00 30.71  ? 250 SER A N   1 
ATOM   1913  C CA  . SER A 1 250 ? 4.520   8.626   -31.630 1.00 33.82  ? 250 SER A CA  1 
ATOM   1914  C C   . SER A 1 250 ? 4.784   9.176   -33.035 1.00 35.21  ? 250 SER A C   1 
ATOM   1915  O O   . SER A 1 250 ? 5.575   8.610   -33.789 1.00 33.41  ? 250 SER A O   1 
ATOM   1916  C CB  . SER A 1 250 ? 3.655   7.405   -31.655 1.00 35.77  ? 250 SER A CB  1 
ATOM   1917  O OG  . SER A 1 250 ? 2.441   7.648   -32.336 1.00 36.46  ? 250 SER A OG  1 
ATOM   1918  N N   . THR A 1 251 ? 4.157   10.300  -33.384 1.00 34.02  ? 251 THR A N   1 
ATOM   1919  C CA  . THR A 1 251 ? 4.470   10.952  -34.640 1.00 39.10  ? 251 THR A CA  1 
ATOM   1920  C C   . THR A 1 251 ? 5.876   11.546  -34.628 1.00 38.29  ? 251 THR A C   1 
ATOM   1921  O O   . THR A 1 251 ? 6.453   11.702  -35.692 1.00 38.89  ? 251 THR A O   1 
ATOM   1922  C CB  . THR A 1 251 ? 3.431   12.012  -34.966 1.00 37.53  ? 251 THR A CB  1 
ATOM   1923  O OG1 . THR A 1 251 ? 3.314   12.734  -33.745 1.00 44.31  ? 251 THR A OG1 1 
ATOM   1924  C CG2 . THR A 1 251 ? 2.109   11.393  -35.355 1.00 39.01  ? 251 THR A CG2 1 
ATOM   1925  N N   . ILE A 1 252 ? 6.448   11.826  -33.456 1.00 36.04  ? 252 ILE A N   1 
ATOM   1926  C CA  . ILE A 1 252 ? 7.767   12.446  -33.408 1.00 37.26  ? 252 ILE A CA  1 
ATOM   1927  C C   . ILE A 1 252 ? 8.821   11.410  -33.739 1.00 33.77  ? 252 ILE A C   1 
ATOM   1928  O O   . ILE A 1 252 ? 9.692   11.638  -34.547 1.00 39.03  ? 252 ILE A O   1 
ATOM   1929  C CB  . ILE A 1 252 ? 8.023   13.093  -32.044 1.00 39.92  ? 252 ILE A CB  1 
ATOM   1930  C CG1 . ILE A 1 252 ? 6.926   14.102  -31.685 1.00 40.00  ? 252 ILE A CG1 1 
ATOM   1931  C CG2 . ILE A 1 252 ? 9.400   13.743  -32.011 1.00 41.89  ? 252 ILE A CG2 1 
ATOM   1932  C CD1 . ILE A 1 252 ? 7.036   14.656  -30.281 1.00 42.28  ? 252 ILE A CD1 1 
ATOM   1933  N N   . GLY A 1 253 ? 8.735   10.253  -33.104 1.00 35.71  ? 253 GLY A N   1 
ATOM   1934  C CA  . GLY A 1 253 ? 9.707   9.209   -33.350 1.00 33.42  ? 253 GLY A CA  1 
ATOM   1935  C C   . GLY A 1 253 ? 9.708   8.214   -32.205 1.00 34.13  ? 253 GLY A C   1 
ATOM   1936  O O   . GLY A 1 253 ? 8.876   8.317   -31.315 1.00 38.15  ? 253 GLY A O   1 
ATOM   1937  N N   . ASP A 1 254 ? 10.598  7.228   -32.300 1.00 31.33  ? 254 ASP A N   1 
ATOM   1938  C CA  . ASP A 1 254 ? 10.715  6.214   -31.287 1.00 31.27  ? 254 ASP A CA  1 
ATOM   1939  C C   . ASP A 1 254 ? 12.202  5.940   -31.060 1.00 34.25  ? 254 ASP A C   1 
ATOM   1940  O O   . ASP A 1 254 ? 12.894  5.539   -31.984 1.00 34.61  ? 254 ASP A O   1 
ATOM   1941  C CB  . ASP A 1 254 ? 9.962   4.971   -31.721 1.00 29.87  ? 254 ASP A CB  1 
ATOM   1942  C CG  . ASP A 1 254 ? 9.838   3.891   -30.663 1.00 31.09  ? 254 ASP A CG  1 
ATOM   1943  O OD1 . ASP A 1 254 ? 10.126  4.204   -29.478 1.00 36.76  ? 254 ASP A OD1 1 
ATOM   1944  O OD2 . ASP A 1 254 ? 9.512   2.728   -31.028 1.00 30.34  ? 254 ASP A OD2 1 
ATOM   1945  N N   . GLU A 1 255 ? 12.659  6.123   -29.814 1.00 32.35  ? 255 GLU A N   1 
ATOM   1946  C CA  . GLU A 1 255 ? 14.015  5.824   -29.372 1.00 30.18  ? 255 GLU A CA  1 
ATOM   1947  C C   . GLU A 1 255 ? 14.231  4.321   -29.209 1.00 31.64  ? 255 GLU A C   1 
ATOM   1948  O O   . GLU A 1 255 ? 14.073  3.790   -28.109 1.00 34.12  ? 255 GLU A O   1 
ATOM   1949  C CB  . GLU A 1 255 ? 14.217  6.530   -28.030 1.00 33.86  ? 255 GLU A CB  1 
ATOM   1950  C CG  . GLU A 1 255 ? 15.642  6.483   -27.473 1.00 39.62  ? 255 GLU A CG  1 
ATOM   1951  C CD  . GLU A 1 255 ? 15.821  7.383   -26.269 1.00 38.85  ? 255 GLU A CD  1 
ATOM   1952  O OE1 . GLU A 1 255 ? 15.179  7.052   -25.242 1.00 38.45  ? 255 GLU A OE1 1 
ATOM   1953  O OE2 . GLU A 1 255 ? 16.521  8.418   -26.367 1.00 37.38  ? 255 GLU A OE2 1 
ATOM   1954  N N   . LEU A 1 256 ? 14.681  3.647   -30.283 1.00 30.43  ? 256 LEU A N   1 
ATOM   1955  C CA  . LEU A 1 256 ? 14.752  2.198   -30.292 1.00 28.66  ? 256 LEU A CA  1 
ATOM   1956  C C   . LEU A 1 256 ? 15.828  1.683   -29.334 1.00 34.69  ? 256 LEU A C   1 
ATOM   1957  O O   . LEU A 1 256 ? 16.820  2.345   -29.074 1.00 40.61  ? 256 LEU A O   1 
ATOM   1958  C CB  . LEU A 1 256 ? 15.008  1.677   -31.698 1.00 26.44  ? 256 LEU A CB  1 
ATOM   1959  C CG  . LEU A 1 256 ? 14.038  2.146   -32.779 1.00 32.29  ? 256 LEU A CG  1 
ATOM   1960  C CD1 . LEU A 1 256 ? 14.380  1.549   -34.138 1.00 32.81  ? 256 LEU A CD1 1 
ATOM   1961  C CD2 . LEU A 1 256 ? 12.596  1.862   -32.431 1.00 33.38  ? 256 LEU A CD2 1 
ATOM   1962  N N   . ASP A 1 257 ? 15.601  0.463   -28.855 1.00 36.29  ? 257 ASP A N   1 
ATOM   1963  C CA  . ASP A 1 257 ? 16.478  -0.300  -27.992 1.00 33.94  ? 257 ASP A CA  1 
ATOM   1964  C C   . ASP A 1 257 ? 16.835  -1.571  -28.753 1.00 34.87  ? 257 ASP A C   1 
ATOM   1965  O O   . ASP A 1 257 ? 16.073  -1.995  -29.623 1.00 30.65  ? 257 ASP A O   1 
ATOM   1966  C CB  . ASP A 1 257 ? 15.745  -0.769  -26.745 1.00 34.05  ? 257 ASP A CB  1 
ATOM   1967  C CG  . ASP A 1 257 ? 15.082  0.349   -25.971 1.00 37.79  ? 257 ASP A CG  1 
ATOM   1968  O OD1 . ASP A 1 257 ? 15.844  1.162   -25.413 1.00 41.55  ? 257 ASP A OD1 1 
ATOM   1969  O OD2 . ASP A 1 257 ? 13.818  0.444   -26.015 1.00 37.64  ? 257 ASP A OD2 1 
ATOM   1970  N N   . GLY A 1 258 ? 17.961  -2.198  -28.405 1.00 37.02  ? 258 GLY A N   1 
ATOM   1971  C CA  . GLY A 1 258 ? 18.280  -3.444  -29.064 1.00 36.11  ? 258 GLY A CA  1 
ATOM   1972  C C   . GLY A 1 258 ? 19.439  -4.200  -28.453 1.00 32.52  ? 258 GLY A C   1 
ATOM   1973  O O   . GLY A 1 258 ? 20.064  -3.782  -27.477 1.00 30.88  ? 258 GLY A O   1 
ATOM   1974  N N   . MET A 1 259 ? 19.639  -5.356  -29.079 1.00 32.44  ? 259 MET A N   1 
ATOM   1975  C CA  . MET A 1 259 ? 20.749  -6.246  -28.856 1.00 30.69  ? 259 MET A CA  1 
ATOM   1976  C C   . MET A 1 259 ? 21.750  -6.021  -29.983 1.00 33.27  ? 259 MET A C   1 
ATOM   1977  O O   . MET A 1 259 ? 21.419  -5.407  -30.997 1.00 31.92  ? 259 MET A O   1 
ATOM   1978  C CB  . MET A 1 259 ? 20.262  -7.694  -28.914 1.00 36.22  ? 259 MET A CB  1 
ATOM   1979  C CG  . MET A 1 259 ? 19.062  -8.036  -28.038 1.00 36.42  ? 259 MET A CG  1 
ATOM   1980  S SD  . MET A 1 259 ? 18.610  -9.774  -28.178 1.00 39.86  ? 259 MET A SD  1 
ATOM   1981  C CE  . MET A 1 259 ? 20.080  -10.460 -27.434 1.00 40.19  ? 259 MET A CE  1 
ATOM   1982  N N   . ALA A 1 260 ? 22.962  -6.565  -29.836 1.00 32.50  ? 260 ALA A N   1 
ATOM   1983  C CA  . ALA A 1 260 ? 23.949  -6.458  -30.903 1.00 32.86  ? 260 ALA A CA  1 
ATOM   1984  C C   . ALA A 1 260 ? 24.754  -7.746  -30.979 1.00 34.79  ? 260 ALA A C   1 
ATOM   1985  O O   . ALA A 1 260 ? 25.111  -8.265  -29.932 1.00 35.82  ? 260 ALA A O   1 
ATOM   1986  C CB  . ALA A 1 260 ? 24.830  -5.295  -30.621 1.00 33.27  ? 260 ALA A CB  1 
ATOM   1987  N N   . TYR A 1 261 ? 24.966  -8.268  -32.203 1.00 38.68  ? 261 TYR A N   1 
ATOM   1988  C CA  . TYR A 1 261 ? 25.766  -9.471  -32.434 1.00 37.54  ? 261 TYR A CA  1 
ATOM   1989  C C   . TYR A 1 261 ? 27.111  -9.068  -33.051 1.00 36.38  ? 261 TYR A C   1 
ATOM   1990  O O   . TYR A 1 261 ? 27.161  -8.271  -33.997 1.00 33.95  ? 261 TYR A O   1 
ATOM   1991  C CB  . TYR A 1 261 ? 25.126  -10.530 -33.339 1.00 40.73  ? 261 TYR A CB  1 
ATOM   1992  C CG  . TYR A 1 261 ? 25.951  -11.811 -33.382 1.00 39.90  ? 261 TYR A CG  1 
ATOM   1993  C CD1 . TYR A 1 261 ? 25.989  -12.665 -32.293 1.00 41.99  ? 261 TYR A CD1 1 
ATOM   1994  C CD2 . TYR A 1 261 ? 26.719  -12.143 -34.483 1.00 42.06  ? 261 TYR A CD2 1 
ATOM   1995  C CE1 . TYR A 1 261 ? 26.780  -13.799 -32.283 1.00 42.29  ? 261 TYR A CE1 1 
ATOM   1996  C CE2 . TYR A 1 261 ? 27.493  -13.288 -34.502 1.00 37.24  ? 261 TYR A CE2 1 
ATOM   1997  C CZ  . TYR A 1 261 ? 27.533  -14.115 -33.395 1.00 42.23  ? 261 TYR A CZ  1 
ATOM   1998  O OH  . TYR A 1 261 ? 28.291  -15.255 -33.369 1.00 38.97  ? 261 TYR A OH  1 
ATOM   1999  N N   . PHE A 1 262 ? 28.191  -9.569  -32.440 1.00 35.54  ? 262 PHE A N   1 
ATOM   2000  C CA  . PHE A 1 262 ? 29.558  -9.332  -32.892 1.00 36.76  ? 262 PHE A CA  1 
ATOM   2001  C C   . PHE A 1 262 ? 30.089  -10.615 -33.536 1.00 38.34  ? 262 PHE A C   1 
ATOM   2002  O O   . PHE A 1 262 ? 30.432  -11.576 -32.855 1.00 36.84  ? 262 PHE A O   1 
ATOM   2003  C CB  . PHE A 1 262 ? 30.474  -8.953  -31.729 1.00 34.51  ? 262 PHE A CB  1 
ATOM   2004  C CG  . PHE A 1 262 ? 30.119  -7.638  -31.061 1.00 36.63  ? 262 PHE A CG  1 
ATOM   2005  C CD1 . PHE A 1 262 ? 28.960  -7.507  -30.309 1.00 33.48  ? 262 PHE A CD1 1 
ATOM   2006  C CD2 . PHE A 1 262 ? 30.957  -6.546  -31.166 1.00 33.46  ? 262 PHE A CD2 1 
ATOM   2007  C CE1 . PHE A 1 262 ? 28.652  -6.300  -29.729 1.00 33.19  ? 262 PHE A CE1 1 
ATOM   2008  C CE2 . PHE A 1 262 ? 30.621  -5.346  -30.600 1.00 32.74  ? 262 PHE A CE2 1 
ATOM   2009  C CZ  . PHE A 1 262 ? 29.460  -5.221  -29.905 1.00 32.92  ? 262 PHE A CZ  1 
ATOM   2010  N N   . ASP A 1 263 ? 30.148  -10.615 -34.859 1.00 37.72  ? 263 ASP A N   1 
ATOM   2011  C CA  . ASP A 1 263 ? 30.629  -11.757 -35.614 1.00 44.67  ? 263 ASP A CA  1 
ATOM   2012  C C   . ASP A 1 263 ? 32.118  -11.614 -35.951 1.00 40.15  ? 263 ASP A C   1 
ATOM   2013  O O   . ASP A 1 263 ? 32.456  -11.065 -36.984 1.00 39.39  ? 263 ASP A O   1 
ATOM   2014  C CB  . ASP A 1 263 ? 29.856  -11.848 -36.913 1.00 44.26  ? 263 ASP A CB  1 
ATOM   2015  C CG  . ASP A 1 263 ? 30.175  -13.068 -37.751 1.00 38.97  ? 263 ASP A CG  1 
ATOM   2016  O OD1 . ASP A 1 263 ? 30.510  -14.106 -37.158 1.00 45.44  ? 263 ASP A OD1 1 
ATOM   2017  O OD2 . ASP A 1 263 ? 30.008  -12.975 -38.969 1.00 43.37  ? 263 ASP A OD2 1 
ATOM   2018  N N   . ASP A 1 264 ? 32.987  -12.130 -35.080 1.00 41.61  ? 264 ASP A N   1 
ATOM   2019  C CA  . ASP A 1 264 ? 34.429  -11.943 -35.170 1.00 40.58  ? 264 ASP A CA  1 
ATOM   2020  C C   . ASP A 1 264 ? 34.713  -10.479 -35.449 1.00 38.38  ? 264 ASP A C   1 
ATOM   2021  O O   . ASP A 1 264 ? 35.292  -10.147 -36.451 1.00 37.04  ? 264 ASP A O   1 
ATOM   2022  C CB  . ASP A 1 264 ? 35.049  -12.897 -36.175 1.00 36.08  ? 264 ASP A CB  1 
ATOM   2023  C CG  . ASP A 1 264 ? 34.914  -14.365 -35.777 1.00 40.53  ? 264 ASP A CG  1 
ATOM   2024  O OD1 . ASP A 1 264 ? 34.623  -14.654 -34.589 1.00 41.68  ? 264 ASP A OD1 1 
ATOM   2025  O OD2 . ASP A 1 264 ? 35.055  -15.220 -36.655 1.00 49.25  ? 264 ASP A OD2 1 
ATOM   2026  N N   . VAL A 1 265 ? 34.252  -9.595  -34.580 1.00 43.89  ? 265 VAL A N   1 
ATOM   2027  C CA  . VAL A 1 265 ? 34.517  -8.188  -34.789 1.00 38.90  ? 265 VAL A CA  1 
ATOM   2028  C C   . VAL A 1 265 ? 35.909  -7.915  -34.273 1.00 41.69  ? 265 VAL A C   1 
ATOM   2029  O O   . VAL A 1 265 ? 36.231  -8.371  -33.187 1.00 45.58  ? 265 VAL A O   1 
ATOM   2030  C CB  . VAL A 1 265 ? 33.517  -7.292  -34.055 1.00 38.97  ? 265 VAL A CB  1 
ATOM   2031  C CG1 . VAL A 1 265 ? 34.022  -5.856  -33.921 1.00 40.17  ? 265 VAL A CG1 1 
ATOM   2032  C CG2 . VAL A 1 265 ? 32.168  -7.330  -34.750 1.00 43.92  ? 265 VAL A CG2 1 
ATOM   2033  N N   . PHE A 1 266 ? 36.669  -7.134  -35.040 1.00 40.96  ? 266 PHE A N   1 
ATOM   2034  C CA  . PHE A 1 266 ? 38.015  -6.749  -34.687 1.00 40.15  ? 266 PHE A CA  1 
ATOM   2035  C C   . PHE A 1 266 ? 37.949  -5.377  -34.043 1.00 37.55  ? 266 PHE A C   1 
ATOM   2036  O O   . PHE A 1 266 ? 37.264  -4.520  -34.556 1.00 38.23  ? 266 PHE A O   1 
ATOM   2037  C CB  . PHE A 1 266 ? 38.958  -6.651  -35.899 1.00 43.06  ? 266 PHE A CB  1 
ATOM   2038  C CG  . PHE A 1 266 ? 40.312  -6.047  -35.553 1.00 38.44  ? 266 PHE A CG  1 
ATOM   2039  C CD1 . PHE A 1 266 ? 41.293  -6.808  -34.934 1.00 39.18  ? 266 PHE A CD1 1 
ATOM   2040  C CD2 . PHE A 1 266 ? 40.586  -4.719  -35.805 1.00 37.55  ? 266 PHE A CD2 1 
ATOM   2041  C CE1 . PHE A 1 266 ? 42.521  -6.255  -34.604 1.00 41.63  ? 266 PHE A CE1 1 
ATOM   2042  C CE2 . PHE A 1 266 ? 41.821  -4.173  -35.475 1.00 44.46  ? 266 PHE A CE2 1 
ATOM   2043  C CZ  . PHE A 1 266 ? 42.787  -4.939  -34.883 1.00 39.29  ? 266 PHE A CZ  1 
ATOM   2044  N N   . ILE A 1 267 ? 38.687  -5.202  -32.940 1.00 38.10  ? 267 ILE A N   1 
ATOM   2045  C CA  . ILE A 1 267 ? 38.809  -3.937  -32.241 1.00 37.31  ? 267 ILE A CA  1 
ATOM   2046  C C   . ILE A 1 267 ? 40.307  -3.672  -32.099 1.00 43.14  ? 267 ILE A C   1 
ATOM   2047  O O   . ILE A 1 267 ? 41.034  -4.543  -31.617 1.00 40.79  ? 267 ILE A O   1 
ATOM   2048  C CB  . ILE A 1 267 ? 38.136  -4.035  -30.861 1.00 35.54  ? 267 ILE A CB  1 
ATOM   2049  C CG1 . ILE A 1 267 ? 36.646  -4.398  -30.964 1.00 38.04  ? 267 ILE A CG1 1 
ATOM   2050  C CG2 . ILE A 1 267 ? 38.336  -2.758  -30.055 1.00 33.57  ? 267 ILE A CG2 1 
ATOM   2051  C CD1 . ILE A 1 267 ? 35.992  -4.684  -29.619 1.00 41.27  ? 267 ILE A CD1 1 
ATOM   2052  N N   . PRO A 1 268 ? 40.818  -2.521  -32.582 1.00 37.85  ? 268 PRO A N   1 
ATOM   2053  C CA  . PRO A 1 268 ? 42.226  -2.162  -32.396 1.00 42.10  ? 268 PRO A CA  1 
ATOM   2054  C C   . PRO A 1 268 ? 42.535  -1.781  -30.957 1.00 41.82  ? 268 PRO A C   1 
ATOM   2055  O O   . PRO A 1 268 ? 41.682  -1.235  -30.283 1.00 45.49  ? 268 PRO A O   1 
ATOM   2056  C CB  . PRO A 1 268 ? 42.398  -0.976  -33.347 1.00 39.12  ? 268 PRO A CB  1 
ATOM   2057  C CG  . PRO A 1 268 ? 41.005  -0.341  -33.386 1.00 40.14  ? 268 PRO A CG  1 
ATOM   2058  C CD  . PRO A 1 268 ? 40.079  -1.552  -33.399 1.00 37.56  ? 268 PRO A CD  1 
ATOM   2059  N N   . TRP A 1 269 ? 43.767  -2.046  -30.512 1.00 44.18  ? 269 TRP A N   1 
ATOM   2060  C CA  . TRP A 1 269 ? 44.175  -1.808  -29.134 1.00 41.66  ? 269 TRP A CA  1 
ATOM   2061  C C   . TRP A 1 269 ? 43.840  -0.402  -28.667 1.00 37.61  ? 269 TRP A C   1 
ATOM   2062  O O   . TRP A 1 269 ? 43.523  -0.198  -27.507 1.00 39.63  ? 269 TRP A O   1 
ATOM   2063  C CB  . TRP A 1 269 ? 45.675  -2.073  -28.943 1.00 43.41  ? 269 TRP A CB  1 
ATOM   2064  C CG  . TRP A 1 269 ? 45.993  -3.542  -28.880 1.00 43.43  ? 269 TRP A CG  1 
ATOM   2065  C CD1 . TRP A 1 269 ? 46.707  -4.264  -29.789 1.00 45.80  ? 269 TRP A CD1 1 
ATOM   2066  C CD2 . TRP A 1 269 ? 45.535  -4.486  -27.892 1.00 40.08  ? 269 TRP A CD2 1 
ATOM   2067  N NE1 . TRP A 1 269 ? 46.737  -5.583  -29.427 1.00 44.08  ? 269 TRP A NE1 1 
ATOM   2068  C CE2 . TRP A 1 269 ? 46.036  -5.747  -28.266 1.00 37.96  ? 269 TRP A CE2 1 
ATOM   2069  C CE3 . TRP A 1 269 ? 44.773  -4.388  -26.729 1.00 41.45  ? 269 TRP A CE3 1 
ATOM   2070  C CZ2 . TRP A 1 269 ? 45.774  -6.896  -27.538 1.00 39.73  ? 269 TRP A CZ2 1 
ATOM   2071  C CZ3 . TRP A 1 269 ? 44.543  -5.526  -25.990 1.00 42.61  ? 269 TRP A CZ3 1 
ATOM   2072  C CH2 . TRP A 1 269 ? 45.022  -6.766  -26.399 1.00 39.31  ? 269 TRP A CH2 1 
ATOM   2073  N N   . GLU A 1 270 ? 43.947  0.573   -29.551 1.00 38.55  ? 270 GLU A N   1 
ATOM   2074  C CA  . GLU A 1 270 ? 43.788  1.947   -29.135 1.00 41.71  ? 270 GLU A CA  1 
ATOM   2075  C C   . GLU A 1 270 ? 42.354  2.177   -28.665 1.00 46.13  ? 270 GLU A C   1 
ATOM   2076  O O   . GLU A 1 270 ? 42.085  3.172   -27.996 1.00 46.95  ? 270 GLU A O   1 
ATOM   2077  C CB  . GLU A 1 270 ? 44.106  2.925   -30.265 1.00 48.75  ? 270 GLU A CB  1 
ATOM   2078  C CG  . GLU A 1 270 ? 45.413  2.621   -30.998 1.00 69.39  ? 270 GLU A CG  1 
ATOM   2079  C CD  . GLU A 1 270 ? 45.245  1.962   -32.363 1.00 74.85  ? 270 GLU A CD  1 
ATOM   2080  O OE1 . GLU A 1 270 ? 45.640  0.774   -32.496 1.00 62.14  ? 270 GLU A OE1 1 
ATOM   2081  O OE2 . GLU A 1 270 ? 44.701  2.646   -33.277 1.00 78.18  ? 270 GLU A OE2 1 
ATOM   2082  N N   . ASN A 1 271 ? 41.433  1.308   -29.088 1.00 40.52  ? 271 ASN A N   1 
ATOM   2083  C CA  . ASN A 1 271 ? 40.024  1.447   -28.752 1.00 44.41  ? 271 ASN A CA  1 
ATOM   2084  C C   . ASN A 1 271 ? 39.649  0.644   -27.509 1.00 49.52  ? 271 ASN A C   1 
ATOM   2085  O O   . ASN A 1 271 ? 38.488  0.639   -27.098 1.00 51.15  ? 271 ASN A O   1 
ATOM   2086  C CB  . ASN A 1 271 ? 39.152  0.964   -29.897 1.00 39.65  ? 271 ASN A CB  1 
ATOM   2087  C CG  . ASN A 1 271 ? 39.050  2.008   -30.976 1.00 43.53  ? 271 ASN A CG  1 
ATOM   2088  O OD1 . ASN A 1 271 ? 39.377  3.181   -30.754 1.00 44.08  ? 271 ASN A OD1 1 
ATOM   2089  N ND2 . ASN A 1 271 ? 38.518  1.619   -32.118 1.00 49.07  ? 271 ASN A ND2 1 
ATOM   2090  N N   . VAL A 1 272 ? 40.621  -0.074  -26.949 1.00 39.27  ? 272 VAL A N   1 
ATOM   2091  C CA  . VAL A 1 272 ? 40.353  -0.954  -25.838 1.00 37.75  ? 272 VAL A CA  1 
ATOM   2092  C C   . VAL A 1 272 ? 40.664  -0.154  -24.591 1.00 39.07  ? 272 VAL A C   1 
ATOM   2093  O O   . VAL A 1 272 ? 41.558  0.664   -24.616 1.00 37.46  ? 272 VAL A O   1 
ATOM   2094  C CB  . VAL A 1 272 ? 41.181  -2.237  -25.913 1.00 34.29  ? 272 VAL A CB  1 
ATOM   2095  C CG1 . VAL A 1 272 ? 40.881  -3.181  -24.776 1.00 35.15  ? 272 VAL A CG1 1 
ATOM   2096  C CG2 . VAL A 1 272 ? 40.951  -2.951  -27.222 1.00 36.56  ? 272 VAL A CG2 1 
ATOM   2097  N N   . GLN A 1 273 ? 39.825  -0.311  -23.573 1.00 41.98  ? 273 GLN A N   1 
ATOM   2098  C CA  . GLN A 1 273 ? 39.963  0.413   -22.330 1.00 40.28  ? 273 GLN A CA  1 
ATOM   2099  C C   . GLN A 1 273 ? 40.351  -0.521  -21.184 1.00 39.56  ? 273 GLN A C   1 
ATOM   2100  O O   . GLN A 1 273 ? 40.926  -0.054  -20.214 1.00 41.98  ? 273 GLN A O   1 
ATOM   2101  C CB  . GLN A 1 273 ? 38.633  1.047   -21.959 1.00 42.35  ? 273 GLN A CB  1 
ATOM   2102  C CG  . GLN A 1 273 ? 38.022  1.958   -23.023 1.00 46.56  ? 273 GLN A CG  1 
ATOM   2103  C CD  . GLN A 1 273 ? 36.573  2.263   -22.695 1.00 41.90  ? 273 GLN A CD  1 
ATOM   2104  O OE1 . GLN A 1 273 ? 35.880  1.441   -22.087 1.00 41.84  ? 273 GLN A OE1 1 
ATOM   2105  N NE2 . GLN A 1 273 ? 36.122  3.462   -22.999 1.00 44.14  ? 273 GLN A NE2 1 
ATOM   2106  N N   . HIS A 1 274 ? 39.996  -1.812  -21.268 1.00 40.22  ? 274 HIS A N   1 
ATOM   2107  C CA  . HIS A 1 274 ? 40.414  -2.812  -20.296 1.00 38.81  ? 274 HIS A CA  1 
ATOM   2108  C C   . HIS A 1 274 ? 39.970  -4.182  -20.787 1.00 41.10  ? 274 HIS A C   1 
ATOM   2109  O O   . HIS A 1 274 ? 38.921  -4.278  -21.397 1.00 44.88  ? 274 HIS A O   1 
ATOM   2110  C CB  . HIS A 1 274 ? 39.761  -2.560  -18.935 1.00 37.53  ? 274 HIS A CB  1 
ATOM   2111  C CG  . HIS A 1 274 ? 39.859  -3.729  -18.023 1.00 37.98  ? 274 HIS A CG  1 
ATOM   2112  N ND1 . HIS A 1 274 ? 40.725  -3.741  -16.947 1.00 40.62  ? 274 HIS A ND1 1 
ATOM   2113  C CD2 . HIS A 1 274 ? 39.257  -4.921  -18.032 1.00 38.21  ? 274 HIS A CD2 1 
ATOM   2114  C CE1 . HIS A 1 274 ? 40.644  -4.925  -16.334 1.00 39.09  ? 274 HIS A CE1 1 
ATOM   2115  N NE2 . HIS A 1 274 ? 39.767  -5.665  -16.983 1.00 41.84  ? 274 HIS A NE2 1 
ATOM   2116  N N   . ILE A 1 275 ? 40.757  -5.231  -20.546 1.00 39.61  ? 275 ILE A N   1 
ATOM   2117  C CA  . ILE A 1 275 ? 40.278  -6.590  -20.763 1.00 42.17  ? 275 ILE A CA  1 
ATOM   2118  C C   . ILE A 1 275 ? 40.798  -7.471  -19.641 1.00 43.82  ? 275 ILE A C   1 
ATOM   2119  O O   . ILE A 1 275 ? 41.792  -7.135  -19.013 1.00 55.26  ? 275 ILE A O   1 
ATOM   2120  C CB  . ILE A 1 275 ? 40.733  -7.164  -22.120 1.00 47.12  ? 275 ILE A CB  1 
ATOM   2121  C CG1 . ILE A 1 275 ? 42.247  -7.020  -22.329 1.00 46.76  ? 275 ILE A CG1 1 
ATOM   2122  C CG2 . ILE A 1 275 ? 39.955  -6.536  -23.274 1.00 49.62  ? 275 ILE A CG2 1 
ATOM   2123  C CD1 . ILE A 1 275 ? 42.851  -8.121  -23.178 1.00 47.53  ? 275 ILE A CD1 1 
ATOM   2124  N N   . GLY A 1 276 ? 40.122  -8.592  -19.389 1.00 45.83  ? 276 GLY A N   1 
ATOM   2125  C CA  . GLY A 1 276 ? 40.767  -9.738  -18.765 1.00 41.83  ? 276 GLY A CA  1 
ATOM   2126  C C   . GLY A 1 276 ? 40.527  -9.930  -17.269 1.00 41.01  ? 276 GLY A C   1 
ATOM   2127  O O   . GLY A 1 276 ? 40.772  -11.018 -16.774 1.00 40.22  ? 276 GLY A O   1 
ATOM   2128  N N   . ASN A 1 277 ? 40.030  -8.924  -16.541 1.00 50.16  ? 277 ASN A N   1 
ATOM   2129  C CA  . ASN A 1 277 ? 39.988  -9.007  -15.090 1.00 47.47  ? 277 ASN A CA  1 
ATOM   2130  C C   . ASN A 1 277 ? 38.558  -8.902  -14.560 1.00 48.18  ? 277 ASN A C   1 
ATOM   2131  O O   . ASN A 1 277 ? 38.059  -7.816  -14.255 1.00 45.12  ? 277 ASN A O   1 
ATOM   2132  C CB  . ASN A 1 277 ? 40.842  -7.919  -14.457 1.00 47.66  ? 277 ASN A CB  1 
ATOM   2133  C CG  . ASN A 1 277 ? 41.013  -8.148  -12.977 1.00 51.97  ? 277 ASN A CG  1 
ATOM   2134  O OD1 . ASN A 1 277 ? 40.251  -8.919  -12.389 1.00 50.21  ? 277 ASN A OD1 1 
ATOM   2135  N ND2 . ASN A 1 277 ? 42.012  -7.523  -12.369 1.00 53.18  ? 277 ASN A ND2 1 
ATOM   2136  N N   . PRO A 1 278 ? 37.898  -10.054 -14.344 1.00 48.40  ? 278 PRO A N   1 
ATOM   2137  C CA  . PRO A 1 278 ? 36.558  -10.110 -13.759 1.00 47.02  ? 278 PRO A CA  1 
ATOM   2138  C C   . PRO A 1 278 ? 36.299  -9.258  -12.528 1.00 48.70  ? 278 PRO A C   1 
ATOM   2139  O O   . PRO A 1 278 ? 35.179  -8.789  -12.341 1.00 56.56  ? 278 PRO A O   1 
ATOM   2140  C CB  . PRO A 1 278 ? 36.378  -11.587 -13.401 1.00 46.58  ? 278 PRO A CB  1 
ATOM   2141  C CG  . PRO A 1 278 ? 37.276  -12.319 -14.346 1.00 47.01  ? 278 PRO A CG  1 
ATOM   2142  C CD  . PRO A 1 278 ? 38.404  -11.376 -14.718 1.00 46.54  ? 278 PRO A CD  1 
ATOM   2143  N N   . ASP A 1 279 ? 37.312  -9.096  -11.675 1.00 47.85  ? 279 ASP A N   1 
ATOM   2144  C CA  . ASP A 1 279 ? 37.126  -8.350  -10.440 1.00 52.85  ? 279 ASP A CA  1 
ATOM   2145  C C   . ASP A 1 279 ? 37.103  -6.844  -10.709 1.00 45.35  ? 279 ASP A C   1 
ATOM   2146  O O   . ASP A 1 279 ? 36.458  -6.097  -9.992  1.00 45.12  ? 279 ASP A O   1 
ATOM   2147  C CB  . ASP A 1 279 ? 38.121  -8.786  -9.376  1.00 63.75  ? 279 ASP A CB  1 
ATOM   2148  C CG  . ASP A 1 279 ? 37.893  -10.190 -8.818  1.00 70.49  ? 279 ASP A CG  1 
ATOM   2149  O OD1 . ASP A 1 279 ? 38.059  -11.181 -9.585  1.00 67.03  ? 279 ASP A OD1 1 
ATOM   2150  O OD2 . ASP A 1 279 ? 37.527  -10.284 -7.622  1.00 63.00  ? 279 ASP A OD2 1 
ATOM   2151  N N   . HIS A 1 280 ? 37.805  -6.389  -11.742 1.00 48.87  ? 280 HIS A N   1 
ATOM   2152  C CA  . HIS A 1 280 ? 37.646  -5.024  -12.214 1.00 46.70  ? 280 HIS A CA  1 
ATOM   2153  C C   . HIS A 1 280 ? 36.165  -4.723  -12.449 1.00 41.58  ? 280 HIS A C   1 
ATOM   2154  O O   . HIS A 1 280 ? 35.711  -3.623  -12.204 1.00 41.48  ? 280 HIS A O   1 
ATOM   2155  C CB  . HIS A 1 280 ? 38.402  -4.807  -13.530 1.00 40.72  ? 280 HIS A CB  1 
ATOM   2156  C CG  . HIS A 1 280 ? 38.432  -3.379  -13.954 1.00 39.14  ? 280 HIS A CG  1 
ATOM   2157  N ND1 . HIS A 1 280 ? 39.202  -2.432  -13.320 1.00 38.09  ? 280 HIS A ND1 1 
ATOM   2158  C CD2 . HIS A 1 280 ? 37.754  -2.728  -14.908 1.00 39.43  ? 280 HIS A CD2 1 
ATOM   2159  C CE1 . HIS A 1 280 ? 39.035  -1.265  -13.920 1.00 38.20  ? 280 HIS A CE1 1 
ATOM   2160  N NE2 . HIS A 1 280 ? 38.147  -1.419  -14.889 1.00 36.49  ? 280 HIS A NE2 1 
ATOM   2161  N N   . ALA A 1 281 ? 35.431  -5.706  -12.957 1.00 38.71  ? 281 ALA A N   1 
ATOM   2162  C CA  . ALA A 1 281 ? 34.057  -5.499  -13.370 1.00 46.18  ? 281 ALA A CA  1 
ATOM   2163  C C   . ALA A 1 281 ? 33.114  -5.435  -12.176 1.00 48.43  ? 281 ALA A C   1 
ATOM   2164  O O   . ALA A 1 281 ? 31.925  -5.221  -12.362 1.00 55.91  ? 281 ALA A O   1 
ATOM   2165  C CB  . ALA A 1 281 ? 33.640  -6.611  -14.303 1.00 42.03  ? 281 ALA A CB  1 
ATOM   2166  N N   . LYS A 1 282 ? 33.635  -5.674  -10.972 1.00 52.65  ? 282 LYS A N   1 
ATOM   2167  C CA  . LYS A 1 282 ? 32.820  -5.681  -9.771  1.00 52.52  ? 282 LYS A CA  1 
ATOM   2168  C C   . LYS A 1 282 ? 32.718  -4.290  -9.160  1.00 55.54  ? 282 LYS A C   1 
ATOM   2169  O O   . LYS A 1 282 ? 31.744  -4.011  -8.472  1.00 73.56  ? 282 LYS A O   1 
ATOM   2170  C CB  . LYS A 1 282 ? 33.412  -6.552  -8.661  1.00 57.03  ? 282 LYS A CB  1 
ATOM   2171  C CG  . LYS A 1 282 ? 33.381  -8.042  -8.910  1.00 59.48  ? 282 LYS A CG  1 
ATOM   2172  C CD  . LYS A 1 282 ? 34.093  -8.839  -7.822  1.00 61.07  ? 282 LYS A CD  1 
ATOM   2173  C CE  . LYS A 1 282 ? 34.022  -10.302 -8.132  1.00 68.22  ? 282 LYS A CE  1 
ATOM   2174  N NZ  . LYS A 1 282 ? 35.049  -11.100 -7.467  1.00 74.38  ? 282 LYS A NZ  1 
ATOM   2175  N N   . TRP A 1 283 ? 33.729  -3.441  -9.357  1.00 53.20  ? 283 TRP A N   1 
ATOM   2176  C CA  . TRP A 1 283 ? 33.762  -2.167  -8.657  1.00 62.67  ? 283 TRP A CA  1 
ATOM   2177  C C   . TRP A 1 283 ? 33.624  -1.008  -9.639  1.00 57.13  ? 283 TRP A C   1 
ATOM   2178  O O   . TRP A 1 283 ? 32.934  -0.047  -9.343  1.00 65.04  ? 283 TRP A O   1 
ATOM   2179  C CB  . TRP A 1 283 ? 35.037  -1.995  -7.806  1.00 80.50  ? 283 TRP A CB  1 
ATOM   2180  C CG  . TRP A 1 283 ? 35.563  -3.236  -7.118  1.00 101.34 ? 283 TRP A CG  1 
ATOM   2181  C CD1 . TRP A 1 283 ? 36.738  -3.881  -7.391  1.00 107.73 ? 283 TRP A CD1 1 
ATOM   2182  C CD2 . TRP A 1 283 ? 34.949  -3.979  -6.037  1.00 112.48 ? 283 TRP A CD2 1 
ATOM   2183  N NE1 . TRP A 1 283 ? 36.900  -4.965  -6.567  1.00 107.71 ? 283 TRP A NE1 1 
ATOM   2184  C CE2 . TRP A 1 283 ? 35.820  -5.053  -5.727  1.00 112.02 ? 283 TRP A CE2 1 
ATOM   2185  C CE3 . TRP A 1 283 ? 33.757  -3.851  -5.312  1.00 106.54 ? 283 TRP A CE3 1 
ATOM   2186  C CZ2 . TRP A 1 283 ? 35.531  -5.982  -4.728  1.00 108.00 ? 283 TRP A CZ2 1 
ATOM   2187  C CZ3 . TRP A 1 283 ? 33.472  -4.774  -4.329  1.00 106.49 ? 283 TRP A CZ3 1 
ATOM   2188  C CH2 . TRP A 1 283 ? 34.349  -5.820  -4.040  1.00 107.75 ? 283 TRP A CH2 1 
ATOM   2189  N N   . TYR A 1 284 ? 34.310  -1.064  -10.787 1.00 53.75  ? 284 TYR A N   1 
ATOM   2190  C CA  . TYR A 1 284 ? 34.483  0.128   -11.601 1.00 49.28  ? 284 TYR A CA  1 
ATOM   2191  C C   . TYR A 1 284 ? 33.266  0.423   -12.479 1.00 41.97  ? 284 TYR A C   1 
ATOM   2192  O O   . TYR A 1 284 ? 32.916  1.587   -12.621 1.00 43.82  ? 284 TYR A O   1 
ATOM   2193  C CB  . TYR A 1 284 ? 35.782  0.051   -12.401 1.00 49.62  ? 284 TYR A CB  1 
ATOM   2194  C CG  . TYR A 1 284 ? 36.969  0.367   -11.518 1.00 46.20  ? 284 TYR A CG  1 
ATOM   2195  C CD1 . TYR A 1 284 ? 37.382  1.674   -11.325 1.00 45.90  ? 284 TYR A CD1 1 
ATOM   2196  C CD2 . TYR A 1 284 ? 37.633  -0.635  -10.835 1.00 48.69  ? 284 TYR A CD2 1 
ATOM   2197  C CE1 . TYR A 1 284 ? 38.449  1.966   -10.497 1.00 44.81  ? 284 TYR A CE1 1 
ATOM   2198  C CE2 . TYR A 1 284 ? 38.697  -0.354  -10.001 1.00 44.76  ? 284 TYR A CE2 1 
ATOM   2199  C CZ  . TYR A 1 284 ? 39.115  0.947   -9.843  1.00 42.87  ? 284 TYR A CZ  1 
ATOM   2200  O OH  . TYR A 1 284 ? 40.168  1.218   -9.017  1.00 46.43  ? 284 TYR A OH  1 
ATOM   2201  N N   . PRO A 1 285 ? 32.575  -0.542  -13.129 1.00 46.84  ? 285 PRO A N   1 
ATOM   2202  C CA  . PRO A 1 285 ? 31.363  -0.186  -13.888 1.00 46.80  ? 285 PRO A CA  1 
ATOM   2203  C C   . PRO A 1 285 ? 30.228  0.446   -13.074 1.00 42.75  ? 285 PRO A C   1 
ATOM   2204  O O   . PRO A 1 285 ? 29.478  1.279   -13.581 1.00 46.46  ? 285 PRO A O   1 
ATOM   2205  C CB  . PRO A 1 285 ? 30.952  -1.498  -14.556 1.00 44.03  ? 285 PRO A CB  1 
ATOM   2206  C CG  . PRO A 1 285 ? 31.629  -2.574  -13.748 1.00 47.10  ? 285 PRO A CG  1 
ATOM   2207  C CD  . PRO A 1 285 ? 32.926  -1.967  -13.250 1.00 46.40  ? 285 PRO A CD  1 
ATOM   2208  N N   . GLN A 1 286 ? 30.154  0.092   -11.793 1.00 43.71  ? 286 GLN A N   1 
ATOM   2209  C CA  . GLN A 1 286 ? 29.154  0.620   -10.878 1.00 43.82  ? 286 GLN A CA  1 
ATOM   2210  C C   . GLN A 1 286 ? 29.385  2.115   -10.669 1.00 41.88  ? 286 GLN A C   1 
ATOM   2211  O O   . GLN A 1 286 ? 28.440  2.880   -10.528 1.00 43.04  ? 286 GLN A O   1 
ATOM   2212  C CB  . GLN A 1 286 ? 29.206  -0.144  -9.556  1.00 46.49  ? 286 GLN A CB  1 
ATOM   2213  C CG  . GLN A 1 286 ? 28.779  -1.608  -9.679  1.00 55.68  ? 286 GLN A CG  1 
ATOM   2214  C CD  . GLN A 1 286 ? 29.801  -2.519  -10.343 1.00 64.54  ? 286 GLN A CD  1 
ATOM   2215  O OE1 . GLN A 1 286 ? 30.981  -2.176  -10.530 1.00 58.07  ? 286 GLN A OE1 1 
ATOM   2216  N NE2 . GLN A 1 286 ? 29.347  -3.710  -10.713 1.00 63.62  ? 286 GLN A NE2 1 
ATOM   2217  N N   . ARG A 1 287 ? 30.642  2.548   -10.744 1.00 40.75  ? 287 ARG A N   1 
ATOM   2218  C CA  . ARG A 1 287 ? 30.970  3.961   -10.606 1.00 43.04  ? 287 ARG A CA  1 
ATOM   2219  C C   . ARG A 1 287 ? 30.616  4.710   -11.877 1.00 40.35  ? 287 ARG A C   1 
ATOM   2220  O O   . ARG A 1 287 ? 30.343  5.907   -11.844 1.00 42.80  ? 287 ARG A O   1 
ATOM   2221  C CB  . ARG A 1 287 ? 32.448  4.132   -10.256 1.00 50.61  ? 287 ARG A CB  1 
ATOM   2222  C CG  . ARG A 1 287 ? 32.730  3.477   -8.910  1.00 60.60  ? 287 ARG A CG  1 
ATOM   2223  C CD  . ARG A 1 287 ? 34.198  3.172   -8.683  1.00 76.66  ? 287 ARG A CD  1 
ATOM   2224  N NE  . ARG A 1 287 ? 35.001  4.399   -8.663  1.00 92.55  ? 287 ARG A NE  1 
ATOM   2225  C CZ  . ARG A 1 287 ? 36.265  4.440   -8.269  1.00 96.74  ? 287 ARG A CZ  1 
ATOM   2226  N NH1 . ARG A 1 287 ? 36.765  3.384   -7.650  1.00 85.11  ? 287 ARG A NH1 1 
ATOM   2227  N NH2 . ARG A 1 287 ? 36.992  5.531   -8.477  1.00 94.93  ? 287 ARG A NH2 1 
ATOM   2228  N N   . GLN A 1 288 ? 30.626  3.997   -12.999 1.00 40.22  ? 288 GLN A N   1 
ATOM   2229  C CA  . GLN A 1 288 ? 30.137  4.572   -14.239 1.00 42.09  ? 288 GLN A CA  1 
ATOM   2230  C C   . GLN A 1 288 ? 28.615  4.677   -14.157 1.00 40.09  ? 288 GLN A C   1 
ATOM   2231  O O   . GLN A 1 288 ? 28.052  5.704   -14.520 1.00 38.16  ? 288 GLN A O   1 
ATOM   2232  C CB  . GLN A 1 288 ? 30.518  3.780   -15.490 1.00 37.90  ? 288 GLN A CB  1 
ATOM   2233  C CG  . GLN A 1 288 ? 32.005  3.470   -15.601 1.00 41.03  ? 288 GLN A CG  1 
ATOM   2234  C CD  . GLN A 1 288 ? 32.322  2.667   -16.841 1.00 41.93  ? 288 GLN A CD  1 
ATOM   2235  O OE1 . GLN A 1 288 ? 32.392  1.431   -16.851 1.00 43.98  ? 288 GLN A OE1 1 
ATOM   2236  N NE2 . GLN A 1 288 ? 32.417  3.390   -17.932 1.00 42.45  ? 288 GLN A NE2 1 
ATOM   2237  N N   . PHE A 1 289 ? 27.942  3.628   -13.672 1.00 40.42  ? 289 PHE A N   1 
ATOM   2238  C CA  . PHE A 1 289 ? 26.486  3.656   -13.700 1.00 45.47  ? 289 PHE A CA  1 
ATOM   2239  C C   . PHE A 1 289 ? 25.969  4.657   -12.680 1.00 41.01  ? 289 PHE A C   1 
ATOM   2240  O O   . PHE A 1 289 ? 24.845  5.096   -12.834 1.00 51.54  ? 289 PHE A O   1 
ATOM   2241  C CB  . PHE A 1 289 ? 25.833  2.268   -13.671 1.00 51.17  ? 289 PHE A CB  1 
ATOM   2242  C CG  . PHE A 1 289 ? 25.676  1.796   -15.110 1.00 56.51  ? 289 PHE A CG  1 
ATOM   2243  C CD1 . PHE A 1 289 ? 26.764  1.306   -15.818 1.00 60.45  ? 289 PHE A CD1 1 
ATOM   2244  C CD2 . PHE A 1 289 ? 24.471  1.952   -15.790 1.00 70.89  ? 289 PHE A CD2 1 
ATOM   2245  C CE1 . PHE A 1 289 ? 26.641  0.937   -17.153 1.00 69.12  ? 289 PHE A CE1 1 
ATOM   2246  C CE2 . PHE A 1 289 ? 24.348  1.581   -17.126 1.00 75.80  ? 289 PHE A CE2 1 
ATOM   2247  C CZ  . PHE A 1 289 ? 25.434  1.068   -17.804 1.00 75.91  ? 289 PHE A CZ  1 
ATOM   2248  N N   . ASP A 1 290 ? 26.792  5.098   -11.723 1.00 38.55  ? 290 ASP A N   1 
ATOM   2249  C CA  . ASP A 1 290 ? 26.358  6.126   -10.788 1.00 39.84  ? 290 ASP A CA  1 
ATOM   2250  C C   . ASP A 1 290 ? 25.892  7.379   -11.527 1.00 40.60  ? 290 ASP A C   1 
ATOM   2251  O O   . ASP A 1 290 ? 25.005  8.104   -11.068 1.00 38.65  ? 290 ASP A O   1 
ATOM   2252  C CB  . ASP A 1 290 ? 27.468  6.529   -9.820  1.00 42.51  ? 290 ASP A CB  1 
ATOM   2253  C CG  . ASP A 1 290 ? 27.732  5.562   -8.675  1.00 40.89  ? 290 ASP A CG  1 
ATOM   2254  O OD1 . ASP A 1 290 ? 26.868  4.714   -8.440  1.00 35.97  ? 290 ASP A OD1 1 
ATOM   2255  O OD2 . ASP A 1 290 ? 28.808  5.656   -8.049  1.00 46.11  ? 290 ASP A OD2 1 
ATOM   2256  N N   . TRP A 1 291 ? 26.555  7.685   -12.643 1.00 41.05  ? 291 TRP A N   1 
ATOM   2257  C CA  . TRP A 1 291 ? 26.302  8.936   -13.336 1.00 39.08  ? 291 TRP A CA  1 
ATOM   2258  C C   . TRP A 1 291 ? 25.030  8.851   -14.175 1.00 38.65  ? 291 TRP A C   1 
ATOM   2259  O O   . TRP A 1 291 ? 24.351  9.836   -14.428 1.00 39.61  ? 291 TRP A O   1 
ATOM   2260  C CB  . TRP A 1 291 ? 27.525  9.245   -14.192 1.00 41.29  ? 291 TRP A CB  1 
ATOM   2261  C CG  . TRP A 1 291 ? 28.652  9.714   -13.337 1.00 37.52  ? 291 TRP A CG  1 
ATOM   2262  C CD1 . TRP A 1 291 ? 29.654  8.989   -12.778 1.00 36.80  ? 291 TRP A CD1 1 
ATOM   2263  C CD2 . TRP A 1 291 ? 28.807  11.063  -12.876 1.00 37.42  ? 291 TRP A CD2 1 
ATOM   2264  N NE1 . TRP A 1 291 ? 30.446  9.813   -12.029 1.00 39.04  ? 291 TRP A NE1 1 
ATOM   2265  C CE2 . TRP A 1 291 ? 29.945  11.082  -12.057 1.00 36.77  ? 291 TRP A CE2 1 
ATOM   2266  C CE3 . TRP A 1 291 ? 28.084  12.239  -13.074 1.00 40.63  ? 291 TRP A CE3 1 
ATOM   2267  C CZ2 . TRP A 1 291 ? 30.386  12.241  -11.434 1.00 39.82  ? 291 TRP A CZ2 1 
ATOM   2268  C CZ3 . TRP A 1 291 ? 28.508  13.381  -12.440 1.00 40.60  ? 291 TRP A CZ3 1 
ATOM   2269  C CH2 . TRP A 1 291 ? 29.632  13.373  -11.620 1.00 39.41  ? 291 TRP A CH2 1 
ATOM   2270  N N   . VAL A 1 292 ? 24.724  7.654   -14.639 1.00 33.69  ? 292 VAL A N   1 
ATOM   2271  C CA  . VAL A 1 292 ? 23.464  7.437   -15.310 1.00 37.96  ? 292 VAL A CA  1 
ATOM   2272  C C   . VAL A 1 292 ? 22.316  7.620   -14.319 1.00 39.71  ? 292 VAL A C   1 
ATOM   2273  O O   . VAL A 1 292 ? 21.338  8.289   -14.602 1.00 47.58  ? 292 VAL A O   1 
ATOM   2274  C CB  . VAL A 1 292 ? 23.537  5.986   -15.809 1.00 42.02  ? 292 VAL A CB  1 
ATOM   2275  C CG1 . VAL A 1 292 ? 22.203  5.519   -16.356 1.00 43.83  ? 292 VAL A CG1 1 
ATOM   2276  C CG2 . VAL A 1 292 ? 24.667  5.796   -16.814 1.00 47.43  ? 292 VAL A CG2 1 
ATOM   2277  N N   . HIS A 1 293 ? 22.441  6.962   -13.165 1.00 38.21  ? 293 HIS A N   1 
ATOM   2278  C CA  . HIS A 1 293 ? 21.466  7.032   -12.092 1.00 39.01  ? 293 HIS A CA  1 
ATOM   2279  C C   . HIS A 1 293 ? 21.176  8.475   -11.698 1.00 36.41  ? 293 HIS A C   1 
ATOM   2280  O O   . HIS A 1 293 ? 20.031  8.841   -11.478 1.00 38.58  ? 293 HIS A O   1 
ATOM   2281  C CB  . HIS A 1 293 ? 21.969  6.239   -10.889 1.00 37.68  ? 293 HIS A CB  1 
ATOM   2282  C CG  . HIS A 1 293 ? 22.039  4.785   -11.152 1.00 34.38  ? 293 HIS A CG  1 
ATOM   2283  N ND1 . HIS A 1 293 ? 22.842  3.955   -10.410 1.00 33.38  ? 293 HIS A ND1 1 
ATOM   2284  C CD2 . HIS A 1 293 ? 21.436  4.018   -12.056 1.00 36.29  ? 293 HIS A CD2 1 
ATOM   2285  C CE1 . HIS A 1 293 ? 22.712  2.704   -10.859 1.00 36.33  ? 293 HIS A CE1 1 
ATOM   2286  N NE2 . HIS A 1 293 ? 21.865  2.722   -11.854 1.00 38.06  ? 293 HIS A NE2 1 
ATOM   2287  N N   . ILE A 1 294 ? 22.219  9.290   -11.625 1.00 36.42  ? 294 ILE A N   1 
ATOM   2288  C CA  . ILE A 1 294 ? 22.065  10.700  -11.317 1.00 36.62  ? 294 ILE A CA  1 
ATOM   2289  C C   . ILE A 1 294 ? 21.165  11.365  -12.343 1.00 38.96  ? 294 ILE A C   1 
ATOM   2290  O O   . ILE A 1 294 ? 20.250  12.078  -11.964 1.00 38.35  ? 294 ILE A O   1 
ATOM   2291  C CB  . ILE A 1 294 ? 23.432  11.376  -11.271 1.00 35.59  ? 294 ILE A CB  1 
ATOM   2292  C CG1 . ILE A 1 294 ? 24.162  10.958  -10.027 1.00 39.63  ? 294 ILE A CG1 1 
ATOM   2293  C CG2 . ILE A 1 294 ? 23.309  12.889  -11.373 1.00 42.35  ? 294 ILE A CG2 1 
ATOM   2294  C CD1 . ILE A 1 294 ? 25.640  11.289  -10.030 1.00 41.29  ? 294 ILE A CD1 1 
ATOM   2295  N N   . GLU A 1 295 ? 21.471  11.147  -13.624 1.00 38.36  ? 295 GLU A N   1 
ATOM   2296  C CA  . GLU A 1 295 ? 20.729  11.726  -14.738 1.00 35.53  ? 295 GLU A CA  1 
ATOM   2297  C C   . GLU A 1 295 ? 19.275  11.228  -14.730 1.00 36.00  ? 295 GLU A C   1 
ATOM   2298  O O   . GLU A 1 295 ? 18.316  12.010  -14.788 1.00 33.78  ? 295 GLU A O   1 
ATOM   2299  C CB  . GLU A 1 295 ? 21.543  11.315  -15.964 1.00 37.73  ? 295 GLU A CB  1 
ATOM   2300  C CG  . GLU A 1 295 ? 20.950  11.795  -17.274 1.00 46.10  ? 295 GLU A CG  1 
ATOM   2301  C CD  . GLU A 1 295 ? 19.936  10.883  -17.916 1.00 39.67  ? 295 GLU A CD  1 
ATOM   2302  O OE1 . GLU A 1 295 ? 19.857  9.706   -17.510 1.00 34.30  ? 295 GLU A OE1 1 
ATOM   2303  O OE2 . GLU A 1 295 ? 19.260  11.388  -18.851 1.00 50.64  ? 295 GLU A OE2 1 
ATOM   2304  N N   . THR A 1 296 ? 19.131  9.912   -14.594 1.00 28.86  ? 296 THR A N   1 
ATOM   2305  C CA  . THR A 1 296 ? 17.839  9.278   -14.541 1.00 32.59  ? 296 THR A CA  1 
ATOM   2306  C C   . THR A 1 296 ? 17.016  9.893   -13.430 1.00 29.73  ? 296 THR A C   1 
ATOM   2307  O O   . THR A 1 296 ? 15.871  10.203  -13.645 1.00 32.80  ? 296 THR A O   1 
ATOM   2308  C CB  . THR A 1 296 ? 17.994  7.771   -14.315 1.00 36.49  ? 296 THR A CB  1 
ATOM   2309  O OG1 . THR A 1 296 ? 18.344  7.237   -15.582 1.00 38.58  ? 296 THR A OG1 1 
ATOM   2310  C CG2 . THR A 1 296 ? 16.693  7.093   -13.930 1.00 37.07  ? 296 THR A CG2 1 
ATOM   2311  N N   . GLN A 1 297 ? 17.600  10.028  -12.245 1.00 31.54  ? 297 GLN A N   1 
ATOM   2312  C CA  . GLN A 1 297 ? 16.854  10.426  -11.061 1.00 33.71  ? 297 GLN A CA  1 
ATOM   2313  C C   . GLN A 1 297 ? 16.355  11.855  -11.227 1.00 34.49  ? 297 GLN A C   1 
ATOM   2314  O O   . GLN A 1 297 ? 15.300  12.223  -10.704 1.00 31.32  ? 297 GLN A O   1 
ATOM   2315  C CB  . GLN A 1 297 ? 17.719  10.347  -9.807  1.00 35.34  ? 297 GLN A CB  1 
ATOM   2316  C CG  . GLN A 1 297 ? 16.952  10.263  -8.489  1.00 34.91  ? 297 GLN A CG  1 
ATOM   2317  C CD  . GLN A 1 297 ? 16.664  11.618  -7.905  1.00 35.54  ? 297 GLN A CD  1 
ATOM   2318  O OE1 . GLN A 1 297 ? 17.532  12.483  -7.935  1.00 37.41  ? 297 GLN A OE1 1 
ATOM   2319  N NE2 . GLN A 1 297 ? 15.454  11.829  -7.397  1.00 36.46  ? 297 GLN A NE2 1 
ATOM   2320  N N   . ILE A 1 298 ? 17.098  12.659  -11.983 1.00 34.96  ? 298 ILE A N   1 
ATOM   2321  C CA  . ILE A 1 298 ? 16.611  13.998  -12.281 1.00 37.53  ? 298 ILE A CA  1 
ATOM   2322  C C   . ILE A 1 298 ? 15.416  13.892  -13.224 1.00 35.53  ? 298 ILE A C   1 
ATOM   2323  O O   . ILE A 1 298 ? 14.435  14.585  -13.043 1.00 35.64  ? 298 ILE A O   1 
ATOM   2324  C CB  . ILE A 1 298 ? 17.715  14.879  -12.867 1.00 40.01  ? 298 ILE A CB  1 
ATOM   2325  C CG1 . ILE A 1 298 ? 18.792  15.177  -11.850 1.00 41.19  ? 298 ILE A CG1 1 
ATOM   2326  C CG2 . ILE A 1 298 ? 17.121  16.169  -13.414 1.00 43.50  ? 298 ILE A CG2 1 
ATOM   2327  C CD1 . ILE A 1 298 ? 20.123  15.558  -12.478 1.00 39.66  ? 298 ILE A CD1 1 
ATOM   2328  N N   . ARG A 1 299 ? 15.487  12.994  -14.208 1.00 33.82  ? 299 ARG A N   1 
ATOM   2329  C CA  . ARG A 1 299 ? 14.375  12.793  -15.112 1.00 34.83  ? 299 ARG A CA  1 
ATOM   2330  C C   . ARG A 1 299 ? 13.108  12.375  -14.359 1.00 36.19  ? 299 ARG A C   1 
ATOM   2331  O O   . ARG A 1 299 ? 12.013  12.835  -14.697 1.00 36.77  ? 299 ARG A O   1 
ATOM   2332  C CB  . ARG A 1 299 ? 14.739  11.747  -16.155 1.00 35.33  ? 299 ARG A CB  1 
ATOM   2333  C CG  . ARG A 1 299 ? 13.651  11.522  -17.188 1.00 39.72  ? 299 ARG A CG  1 
ATOM   2334  C CD  . ARG A 1 299 ? 14.193  10.730  -18.369 1.00 42.62  ? 299 ARG A CD  1 
ATOM   2335  N NE  . ARG A 1 299 ? 14.533  9.361   -17.967 1.00 44.23  ? 299 ARG A NE  1 
ATOM   2336  C CZ  . ARG A 1 299 ? 15.775  8.885   -17.872 1.00 45.90  ? 299 ARG A CZ  1 
ATOM   2337  N NH1 . ARG A 1 299 ? 16.813  9.683   -18.040 1.00 40.58  ? 299 ARG A NH1 1 
ATOM   2338  N NH2 . ARG A 1 299 ? 15.979  7.618   -17.552 1.00 49.39  ? 299 ARG A NH2 1 
ATOM   2339  N N   . HIS A 1 300 ? 13.270  11.514  -13.346 1.00 33.25  ? 300 HIS A N   1 
ATOM   2340  C CA  . HIS A 1 300 ? 12.165  11.038  -12.531 1.00 31.26  ? 300 HIS A CA  1 
ATOM   2341  C C   . HIS A 1 300 ? 11.364  12.232  -12.049 1.00 30.62  ? 300 HIS A C   1 
ATOM   2342  O O   . HIS A 1 300 ? 10.137  12.311  -12.179 1.00 31.33  ? 300 HIS A O   1 
ATOM   2343  C CB  . HIS A 1 300 ? 12.694  10.198  -11.367 1.00 32.10  ? 300 HIS A CB  1 
ATOM   2344  C CG  . HIS A 1 300 ? 13.169  8.855   -11.768 1.00 31.34  ? 300 HIS A CG  1 
ATOM   2345  N ND1 . HIS A 1 300 ? 13.813  8.038   -10.863 1.00 32.18  ? 300 HIS A ND1 1 
ATOM   2346  C CD2 . HIS A 1 300 ? 13.033  8.140   -12.895 1.00 28.79  ? 300 HIS A CD2 1 
ATOM   2347  C CE1 . HIS A 1 300 ? 14.098  6.876   -11.441 1.00 26.32  ? 300 HIS A CE1 1 
ATOM   2348  N NE2 . HIS A 1 300 ? 13.652  6.924   -12.679 1.00 30.49  ? 300 HIS A NE2 1 
ATOM   2349  N N   . ALA A 1 301 ? 12.089  13.190  -11.497 1.00 29.07  ? 301 ALA A N   1 
ATOM   2350  C CA  . ALA A 1 301 ? 11.426  14.311  -10.873 1.00 30.73  ? 301 ALA A CA  1 
ATOM   2351  C C   . ALA A 1 301 ? 10.678  15.114  -11.924 1.00 33.22  ? 301 ALA A C   1 
ATOM   2352  O O   . ALA A 1 301 ? 9.600   15.643  -11.664 1.00 41.52  ? 301 ALA A O   1 
ATOM   2353  C CB  . ALA A 1 301 ? 12.425  15.150  -10.141 1.00 33.46  ? 301 ALA A CB  1 
ATOM   2354  N N   . VAL A 1 302 ? 11.240  15.212  -13.124 1.00 34.65  ? 302 VAL A N   1 
ATOM   2355  C CA  . VAL A 1 302 ? 10.591  15.986  -14.171 1.00 31.15  ? 302 VAL A CA  1 
ATOM   2356  C C   . VAL A 1 302 ? 9.352   15.251  -14.669 1.00 27.56  ? 302 VAL A C   1 
ATOM   2357  O O   . VAL A 1 302 ? 8.359   15.878  -14.997 1.00 27.70  ? 302 VAL A O   1 
ATOM   2358  C CB  . VAL A 1 302 ? 11.558  16.289  -15.324 1.00 34.57  ? 302 VAL A CB  1 
ATOM   2359  C CG1 . VAL A 1 302 ? 10.887  17.138  -16.380 1.00 34.16  ? 302 VAL A CG1 1 
ATOM   2360  C CG2 . VAL A 1 302 ? 12.780  17.029  -14.817 1.00 34.49  ? 302 VAL A CG2 1 
ATOM   2361  N N   . HIS A 1 303 ? 9.414   13.921  -14.720 1.00 26.78  ? 303 HIS A N   1 
ATOM   2362  C CA  . HIS A 1 303 ? 8.300   13.130  -15.186 1.00 28.71  ? 303 HIS A CA  1 
ATOM   2363  C C   . HIS A 1 303 ? 7.149   13.306  -14.192 1.00 29.87  ? 303 HIS A C   1 
ATOM   2364  O O   . HIS A 1 303 ? 6.015   13.608  -14.586 1.00 26.84  ? 303 HIS A O   1 
ATOM   2365  C CB  . HIS A 1 303 ? 8.751   11.684  -15.430 1.00 29.93  ? 303 HIS A CB  1 
ATOM   2366  C CG  . HIS A 1 303 ? 7.680   10.819  -16.003 1.00 34.57  ? 303 HIS A CG  1 
ATOM   2367  N ND1 . HIS A 1 303 ? 7.530   9.461   -15.785 1.00 37.04  ? 303 HIS A ND1 1 
ATOM   2368  C CD2 . HIS A 1 303 ? 6.660   11.193  -16.792 1.00 35.94  ? 303 HIS A CD2 1 
ATOM   2369  C CE1 . HIS A 1 303 ? 6.436   9.058   -16.431 1.00 38.44  ? 303 HIS A CE1 1 
ATOM   2370  N NE2 . HIS A 1 303 ? 5.911   10.097  -17.065 1.00 34.81  ? 303 HIS A NE2 1 
ATOM   2371  N N   . ALA A 1 304 ? 7.457   13.170  -12.895 1.00 29.26  ? 304 ALA A N   1 
ATOM   2372  C CA  . ALA A 1 304 ? 6.472   13.417  -11.844 1.00 29.25  ? 304 ALA A CA  1 
ATOM   2373  C C   . ALA A 1 304 ? 5.921   14.838  -11.944 1.00 26.64  ? 304 ALA A C   1 
ATOM   2374  O O   . ALA A 1 304 ? 4.726   15.069  -11.811 1.00 29.04  ? 304 ALA A O   1 
ATOM   2375  C CB  . ALA A 1 304 ? 7.091   13.142  -10.469 1.00 31.46  ? 304 ALA A CB  1 
ATOM   2376  N N   . GLU A 1 305 ? 6.742   15.809  -12.318 1.00 30.09  ? 305 GLU A N   1 
ATOM   2377  C CA  . GLU A 1 305 ? 6.185   17.148  -12.532 1.00 31.36  ? 305 GLU A CA  1 
ATOM   2378  C C   . GLU A 1 305 ? 5.174   17.097  -13.662 1.00 33.28  ? 305 GLU A C   1 
ATOM   2379  O O   . GLU A 1 305 ? 4.102   17.704  -13.595 1.00 32.51  ? 305 GLU A O   1 
ATOM   2380  C CB  . GLU A 1 305 ? 7.323   18.135  -12.766 1.00 33.71  ? 305 GLU A CB  1 
ATOM   2381  C CG  . GLU A 1 305 ? 6.933   19.538  -13.217 1.00 34.21  ? 305 GLU A CG  1 
ATOM   2382  C CD  . GLU A 1 305 ? 8.120   20.478  -13.338 1.00 35.22  ? 305 GLU A CD  1 
ATOM   2383  O OE1 . GLU A 1 305 ? 9.212   20.147  -12.849 1.00 39.90  ? 305 GLU A OE1 1 
ATOM   2384  O OE2 . GLU A 1 305 ? 7.957   21.552  -13.936 1.00 37.87  ? 305 GLU A OE2 1 
ATOM   2385  N N   . LEU A 1 306 ? 5.516   16.366  -14.720 1.00 33.76  ? 306 LEU A N   1 
ATOM   2386  C CA  . LEU A 1 306 ? 4.631   16.344  -15.867 1.00 32.37  ? 306 LEU A CA  1 
ATOM   2387  C C   . LEU A 1 306 ? 3.316   15.672  -15.488 1.00 32.50  ? 306 LEU A C   1 
ATOM   2388  O O   . LEU A 1 306 ? 2.248   16.106  -15.889 1.00 31.67  ? 306 LEU A O   1 
ATOM   2389  C CB  . LEU A 1 306 ? 5.286   15.647  -17.040 1.00 34.69  ? 306 LEU A CB  1 
ATOM   2390  C CG  . LEU A 1 306 ? 4.326   15.357  -18.194 1.00 38.07  ? 306 LEU A CG  1 
ATOM   2391  C CD1 . LEU A 1 306 ? 4.040   16.598  -18.969 1.00 37.85  ? 306 LEU A CD1 1 
ATOM   2392  C CD2 . LEU A 1 306 ? 4.878   14.291  -19.076 1.00 44.51  ? 306 LEU A CD2 1 
ATOM   2393  N N   . ILE A 1 307 ? 3.398   14.620  -14.687 1.00 32.12  ? 307 ILE A N   1 
ATOM   2394  C CA  . ILE A 1 307 ? 2.225   13.870  -14.289 1.00 30.36  ? 307 ILE A CA  1 
ATOM   2395  C C   . ILE A 1 307 ? 1.302   14.744  -13.454 1.00 31.35  ? 307 ILE A C   1 
ATOM   2396  O O   . ILE A 1 307 ? 0.125   14.872  -13.745 1.00 37.21  ? 307 ILE A O   1 
ATOM   2397  C CB  . ILE A 1 307 ? 2.676   12.600  -13.548 1.00 31.90  ? 307 ILE A CB  1 
ATOM   2398  C CG1 . ILE A 1 307 ? 3.193   11.565  -14.561 1.00 32.90  ? 307 ILE A CG1 1 
ATOM   2399  C CG2 . ILE A 1 307 ? 1.566   12.048  -12.664 1.00 30.03  ? 307 ILE A CG2 1 
ATOM   2400  C CD1 . ILE A 1 307 ? 3.948   10.392  -13.963 1.00 36.25  ? 307 ILE A CD1 1 
ATOM   2401  N N   . VAL A 1 308 ? 1.826   15.388  -12.426 1.00 35.33  ? 308 VAL A N   1 
ATOM   2402  C CA  . VAL A 1 308 ? 0.958   16.223  -11.614 1.00 34.92  ? 308 VAL A CA  1 
ATOM   2403  C C   . VAL A 1 308 ? 0.397   17.362  -12.446 1.00 27.33  ? 308 VAL A C   1 
ATOM   2404  O O   . VAL A 1 308 ? -0.769  17.712  -12.305 1.00 31.98  ? 308 VAL A O   1 
ATOM   2405  C CB  . VAL A 1 308 ? 1.575   16.737  -10.301 1.00 39.99  ? 308 VAL A CB  1 
ATOM   2406  C CG1 . VAL A 1 308 ? 2.925   17.355  -10.477 1.00 39.21  ? 308 VAL A CG1 1 
ATOM   2407  C CG2 . VAL A 1 308 ? 0.657   17.736  -9.619  1.00 49.20  ? 308 VAL A CG2 1 
ATOM   2408  N N   . GLY A 1 309 ? 1.177   17.904  -13.363 1.00 28.88  ? 309 GLY A N   1 
ATOM   2409  C CA  . GLY A 1 309 ? 0.670   18.965  -14.235 1.00 29.91  ? 309 GLY A CA  1 
ATOM   2410  C C   . GLY A 1 309 ? -0.531  18.495  -15.043 1.00 33.82  ? 309 GLY A C   1 
ATOM   2411  O O   . GLY A 1 309 ? -1.586  19.139  -15.048 1.00 34.98  ? 309 GLY A O   1 
ATOM   2412  N N   . LEU A 1 310 ? -0.380  17.337  -15.702 1.00 32.80  ? 310 LEU A N   1 
ATOM   2413  C CA  . LEU A 1 310 ? -1.459  16.804  -16.512 1.00 31.15  ? 310 LEU A CA  1 
ATOM   2414  C C   . LEU A 1 310 ? -2.685  16.559  -15.635 1.00 35.86  ? 310 LEU A C   1 
ATOM   2415  O O   . LEU A 1 310 ? -3.828  16.722  -16.061 1.00 36.93  ? 310 LEU A O   1 
ATOM   2416  C CB  . LEU A 1 310 ? -1.000  15.516  -17.181 1.00 31.54  ? 310 LEU A CB  1 
ATOM   2417  C CG  . LEU A 1 310 ? -0.037  15.646  -18.355 1.00 31.10  ? 310 LEU A CG  1 
ATOM   2418  C CD1 . LEU A 1 310 ? 0.415   14.285  -18.753 1.00 30.50  ? 310 LEU A CD1 1 
ATOM   2419  C CD2 . LEU A 1 310 ? -0.686  16.340  -19.526 1.00 32.27  ? 310 LEU A CD2 1 
ATOM   2420  N N   . ALA A 1 311 ? -2.449  16.111  -14.406 1.00 34.10  ? 311 ALA A N   1 
ATOM   2421  C CA  . ALA A 1 311 ? -3.554  15.764  -13.536 1.00 34.25  ? 311 ALA A CA  1 
ATOM   2422  C C   . ALA A 1 311 ? -4.312  17.024  -13.139 1.00 34.61  ? 311 ALA A C   1 
ATOM   2423  O O   . ALA A 1 311 ? -5.540  17.045  -13.060 1.00 33.00  ? 311 ALA A O   1 
ATOM   2424  C CB  . ALA A 1 311 ? -3.029  15.041  -12.332 1.00 37.14  ? 311 ALA A CB  1 
ATOM   2425  N N   . LEU A 1 312 ? -3.564  18.084  -12.865 1.00 37.54  ? 312 LEU A N   1 
ATOM   2426  C CA  . LEU A 1 312 ? -4.202  19.352  -12.538 1.00 38.27  ? 312 LEU A CA  1 
ATOM   2427  C C   . LEU A 1 312 ? -5.064  19.829  -13.700 1.00 33.60  ? 312 LEU A C   1 
ATOM   2428  O O   . LEU A 1 312 ? -6.203  20.218  -13.493 1.00 40.29  ? 312 LEU A O   1 
ATOM   2429  C CB  . LEU A 1 312 ? -3.179  20.413  -12.152 1.00 37.13  ? 312 LEU A CB  1 
ATOM   2430  C CG  . LEU A 1 312 ? -2.697  20.368  -10.705 1.00 39.52  ? 312 LEU A CG  1 
ATOM   2431  C CD1 . LEU A 1 312 ? -1.544  21.346  -10.401 1.00 43.98  ? 312 LEU A CD1 1 
ATOM   2432  C CD2 . LEU A 1 312 ? -3.868  20.705  -9.811  1.00 37.20  ? 312 LEU A CD2 1 
ATOM   2433  N N   . LEU A 1 313 ? -4.538  19.768  -14.920 1.00 31.95  ? 313 LEU A N   1 
ATOM   2434  C CA  . LEU A 1 313 ? -5.268  20.267  -16.073 1.00 31.39  ? 313 LEU A CA  1 
ATOM   2435  C C   . LEU A 1 313 ? -6.491  19.396  -16.279 1.00 35.71  ? 313 LEU A C   1 
ATOM   2436  O O   . LEU A 1 313 ? -7.581  19.902  -16.537 1.00 39.97  ? 313 LEU A O   1 
ATOM   2437  C CB  . LEU A 1 313 ? -4.391  20.270  -17.328 1.00 30.97  ? 313 LEU A CB  1 
ATOM   2438  C CG  . LEU A 1 313 ? -3.295  21.337  -17.362 1.00 36.61  ? 313 LEU A CG  1 
ATOM   2439  C CD1 . LEU A 1 313 ? -2.225  21.018  -18.373 1.00 38.31  ? 313 LEU A CD1 1 
ATOM   2440  C CD2 . LEU A 1 313 ? -3.872  22.707  -17.663 1.00 37.80  ? 313 LEU A CD2 1 
ATOM   2441  N N   . LEU A 1 314 ? -6.272  18.077  -16.174 1.00 34.54  ? 314 LEU A N   1 
ATOM   2442  C CA  . LEU A 1 314 ? -7.324  17.118  -16.427 1.00 31.41  ? 314 LEU A CA  1 
ATOM   2443  C C   . LEU A 1 314 ? -8.482  17.303  -15.454 1.00 32.47  ? 314 LEU A C   1 
ATOM   2444  O O   . LEU A 1 314 ? -9.634  17.336  -15.873 1.00 34.78  ? 314 LEU A O   1 
ATOM   2445  C CB  . LEU A 1 314 ? -6.757  15.714  -16.330 1.00 31.84  ? 314 LEU A CB  1 
ATOM   2446  C CG  . LEU A 1 314 ? -7.783  14.608  -16.504 1.00 34.66  ? 314 LEU A CG  1 
ATOM   2447  C CD1 . LEU A 1 314 ? -8.355  14.567  -17.896 1.00 37.06  ? 314 LEU A CD1 1 
ATOM   2448  C CD2 . LEU A 1 314 ? -7.126  13.310  -16.150 1.00 39.78  ? 314 LEU A CD2 1 
ATOM   2449  N N   . THR A 1 315 ? -8.203  17.357  -14.152 1.00 32.44  ? 315 THR A N   1 
ATOM   2450  C CA  . THR A 1 315 ? -9.294  17.383  -13.198 1.00 33.09  ? 315 THR A CA  1 
ATOM   2451  C C   . THR A 1 315 ? -9.975  18.743  -13.259 1.00 36.02  ? 315 THR A C   1 
ATOM   2452  O O   . THR A 1 315 ? -11.188 18.856  -13.085 1.00 42.27  ? 315 THR A O   1 
ATOM   2453  C CB  . THR A 1 315 ? -8.786  17.026  -11.807 1.00 34.48  ? 315 THR A CB  1 
ATOM   2454  O OG1 . THR A 1 315 ? -7.738  17.939  -11.565 1.00 32.68  ? 315 THR A OG1 1 
ATOM   2455  C CG2 . THR A 1 315 ? -8.287  15.590  -11.757 1.00 35.69  ? 315 THR A CG2 1 
ATOM   2456  N N   . ASN A 1 316 ? -9.201  19.770  -13.577 1.00 36.87  ? 316 ASN A N   1 
ATOM   2457  C CA  . ASN A 1 316 ? -9.784  21.072  -13.806 1.00 37.66  ? 316 ASN A CA  1 
ATOM   2458  C C   . ASN A 1 316 ? -10.691 21.006  -15.029 1.00 39.37  ? 316 ASN A C   1 
ATOM   2459  O O   . ASN A 1 316 ? -11.838 21.425  -14.997 1.00 44.26  ? 316 ASN A O   1 
ATOM   2460  C CB  . ASN A 1 316 ? -8.699  22.122  -13.931 1.00 41.94  ? 316 ASN A CB  1 
ATOM   2461  C CG  . ASN A 1 316 ? -9.284  23.508  -13.927 1.00 46.84  ? 316 ASN A CG  1 
ATOM   2462  O OD1 . ASN A 1 316 ? -9.515  24.069  -14.996 1.00 57.53  ? 316 ASN A OD1 1 
ATOM   2463  N ND2 . ASN A 1 316 ? -9.585  24.039  -12.754 1.00 45.59  ? 316 ASN A ND2 1 
ATOM   2464  N N   . ALA A 1 317 ? -10.214 20.414  -16.115 1.00 35.87  ? 317 ALA A N   1 
ATOM   2465  C CA  . ALA A 1 317 ? -11.028 20.390  -17.312 1.00 35.79  ? 317 ALA A CA  1 
ATOM   2466  C C   . ALA A 1 317 ? -12.311 19.594  -17.103 1.00 36.94  ? 317 ALA A C   1 
ATOM   2467  O O   . ALA A 1 317 ? -13.289 19.811  -17.794 1.00 41.71  ? 317 ALA A O   1 
ATOM   2468  C CB  . ALA A 1 317 ? -10.209 19.827  -18.438 1.00 35.43  ? 317 ALA A CB  1 
ATOM   2469  N N   . LEU A 1 318 ? -12.277 18.598  -16.214 1.00 42.72  ? 318 LEU A N   1 
ATOM   2470  C CA  . LEU A 1 318 ? -13.405 17.714  -16.024 1.00 40.17  ? 318 LEU A CA  1 
ATOM   2471  C C   . LEU A 1 318 ? -14.331 18.236  -14.928 1.00 42.79  ? 318 LEU A C   1 
ATOM   2472  O O   . LEU A 1 318 ? -15.418 17.711  -14.786 1.00 45.73  ? 318 LEU A O   1 
ATOM   2473  C CB  . LEU A 1 318 ? -12.968 16.290  -15.686 1.00 39.89  ? 318 LEU A CB  1 
ATOM   2474  C CG  . LEU A 1 318 ? -12.484 15.415  -16.839 1.00 40.30  ? 318 LEU A CG  1 
ATOM   2475  C CD1 . LEU A 1 318 ? -11.824 14.167  -16.243 1.00 41.93  ? 318 LEU A CD1 1 
ATOM   2476  C CD2 . LEU A 1 318 ? -13.597 15.033  -17.780 1.00 39.01  ? 318 LEU A CD2 1 
ATOM   2477  N N   . GLY A 1 319 ? -13.889 19.179  -14.099 1.00 45.36  ? 319 GLY A N   1 
ATOM   2478  C CA  . GLY A 1 319 ? -14.732 19.739  -13.052 1.00 42.15  ? 319 GLY A CA  1 
ATOM   2479  C C   . GLY A 1 319 ? -14.589 19.006  -11.714 1.00 47.78  ? 319 GLY A C   1 
ATOM   2480  O O   . GLY A 1 319 ? -15.368 19.252  -10.796 1.00 43.67  ? 319 GLY A O   1 
ATOM   2481  N N   . THR A 1 320 ? -13.554 18.169  -11.555 1.00 42.56  ? 320 THR A N   1 
ATOM   2482  C CA  . THR A 1 320 ? -13.497 17.285  -10.402 1.00 38.19  ? 320 THR A CA  1 
ATOM   2483  C C   . THR A 1 320 ? -12.462 17.755  -9.387  1.00 39.38  ? 320 THR A C   1 
ATOM   2484  O O   . THR A 1 320 ? -12.283 17.122  -8.351  1.00 40.33  ? 320 THR A O   1 
ATOM   2485  C CB  . THR A 1 320 ? -13.193 15.860  -10.851 1.00 41.95  ? 320 THR A CB  1 
ATOM   2486  O OG1 . THR A 1 320 ? -11.964 15.905  -11.591 1.00 40.16  ? 320 THR A OG1 1 
ATOM   2487  C CG2 . THR A 1 320 ? -14.332 15.275  -11.673 1.00 38.18  ? 320 THR A CG2 1 
ATOM   2488  N N   . ASN A 1 321 ? -11.786 18.869  -9.639  1.00 42.40  ? 321 ASN A N   1 
ATOM   2489  C CA  . ASN A 1 321 ? -10.641 19.200  -8.804  1.00 47.46  ? 321 ASN A CA  1 
ATOM   2490  C C   . ASN A 1 321 ? -11.082 19.810  -7.462  1.00 50.42  ? 321 ASN A C   1 
ATOM   2491  O O   . ASN A 1 321 ? -10.232 20.062  -6.604  1.00 52.25  ? 321 ASN A O   1 
ATOM   2492  C CB  . ASN A 1 321 ? -9.634  20.045  -9.576  1.00 49.71  ? 321 ASN A CB  1 
ATOM   2493  C CG  . ASN A 1 321 ? -10.176 21.404  -9.933  1.00 51.07  ? 321 ASN A CG  1 
ATOM   2494  O OD1 . ASN A 1 321 ? -11.278 21.529  -10.485 1.00 56.94  ? 321 ASN A OD1 1 
ATOM   2495  N ND2 . ASN A 1 321 ? -9.439  22.434  -9.565  1.00 60.17  ? 321 ASN A ND2 1 
ATOM   2496  N N   . ASN A 1 322 ? -12.399 19.980  -7.255  1.00 51.30  ? 322 ASN A N   1 
ATOM   2497  C CA  . ASN A 1 322 ? -12.936 20.452  -5.984  1.00 63.03  ? 322 ASN A CA  1 
ATOM   2498  C C   . ASN A 1 322 ? -13.474 19.318  -5.113  1.00 52.62  ? 322 ASN A C   1 
ATOM   2499  O O   . ASN A 1 322 ? -13.724 19.555  -3.942  1.00 51.61  ? 322 ASN A O   1 
ATOM   2500  C CB  . ASN A 1 322 ? -14.000 21.526  -6.181  1.00 76.74  ? 322 ASN A CB  1 
ATOM   2501  C CG  . ASN A 1 322 ? -13.446 22.691  -6.976  1.00 99.00  ? 322 ASN A CG  1 
ATOM   2502  O OD1 . ASN A 1 322 ? -14.024 23.085  -8.000  1.00 102.16 ? 322 ASN A OD1 1 
ATOM   2503  N ND2 . ASN A 1 322 ? -12.312 23.233  -6.544  1.00 91.00  ? 322 ASN A ND2 1 
ATOM   2504  N N   . ASN A 1 323 ? -13.644 18.106  -5.662  1.00 48.24  ? 323 ASN A N   1 
ATOM   2505  C CA  . ASN A 1 323 ? -13.892 16.917  -4.858  1.00 44.37  ? 323 ASN A CA  1 
ATOM   2506  C C   . ASN A 1 323 ? -12.763 16.756  -3.841  1.00 42.53  ? 323 ASN A C   1 
ATOM   2507  O O   . ASN A 1 323 ? -11.586 16.738  -4.182  1.00 39.52  ? 323 ASN A O   1 
ATOM   2508  C CB  . ASN A 1 323 ? -14.018 15.675  -5.736  1.00 52.15  ? 323 ASN A CB  1 
ATOM   2509  C CG  . ASN A 1 323 ? -14.312 14.400  -4.968  1.00 57.49  ? 323 ASN A CG  1 
ATOM   2510  O OD1 . ASN A 1 323 ? -13.890 14.215  -3.820  1.00 59.36  ? 323 ASN A OD1 1 
ATOM   2511  N ND2 . ASN A 1 323 ? -15.045 13.491  -5.593  1.00 63.72  ? 323 ASN A ND2 1 
ATOM   2512  N N   . PRO A 1 324 ? -13.057 16.638  -2.538  1.00 40.15  ? 324 PRO A N   1 
ATOM   2513  C CA  . PRO A 1 324 ? -11.996 16.441  -1.567  1.00 41.09  ? 324 PRO A CA  1 
ATOM   2514  C C   . PRO A 1 324 ? -11.154 15.189  -1.796  1.00 42.38  ? 324 PRO A C   1 
ATOM   2515  O O   . PRO A 1 324 ? -9.960  15.209  -1.481  1.00 41.01  ? 324 PRO A O   1 
ATOM   2516  C CB  . PRO A 1 324 ? -12.753 16.398  -0.247  1.00 42.54  ? 324 PRO A CB  1 
ATOM   2517  C CG  . PRO A 1 324 ? -14.032 17.140  -0.527  1.00 40.16  ? 324 PRO A CG  1 
ATOM   2518  C CD  . PRO A 1 324 ? -14.393 16.705  -1.931  1.00 40.52  ? 324 PRO A CD  1 
ATOM   2519  N N   . ILE A 1 325 ? -11.737 14.127  -2.375  1.00 35.54  ? 325 ILE A N   1 
ATOM   2520  C CA  . ILE A 1 325 ? -10.971 12.917  -2.615  1.00 37.07  ? 325 ILE A CA  1 
ATOM   2521  C C   . ILE A 1 325 ? -9.937  13.212  -3.704  1.00 38.17  ? 325 ILE A C   1 
ATOM   2522  O O   . ILE A 1 325 ? -8.754  12.880  -3.584  1.00 37.55  ? 325 ILE A O   1 
ATOM   2523  C CB  . ILE A 1 325 ? -11.874 11.712  -2.961  1.00 44.67  ? 325 ILE A CB  1 
ATOM   2524  C CG1 . ILE A 1 325 ? -12.861 11.374  -1.837  1.00 44.87  ? 325 ILE A CG1 1 
ATOM   2525  C CG2 . ILE A 1 325 ? -11.041 10.475  -3.320  1.00 45.60  ? 325 ILE A CG2 1 
ATOM   2526  C CD1 . ILE A 1 325 ? -13.977 10.433  -2.261  1.00 41.88  ? 325 ILE A CD1 1 
ATOM   2527  N N   . VAL A 1 326 ? -10.398 13.854  -4.770  1.00 36.65  ? 326 VAL A N   1 
ATOM   2528  C CA  . VAL A 1 326 ? -9.535  14.234  -5.874  1.00 35.47  ? 326 VAL A CA  1 
ATOM   2529  C C   . VAL A 1 326 ? -8.440  15.160  -5.358  1.00 36.41  ? 326 VAL A C   1 
ATOM   2530  O O   . VAL A 1 326 ? -7.271  14.978  -5.671  1.00 41.69  ? 326 VAL A O   1 
ATOM   2531  C CB  . VAL A 1 326 ? -10.372 14.894  -6.983  1.00 33.24  ? 326 VAL A CB  1 
ATOM   2532  C CG1 . VAL A 1 326 ? -9.507  15.525  -8.043  1.00 35.89  ? 326 VAL A CG1 1 
ATOM   2533  C CG2 . VAL A 1 326 ? -11.292 13.895  -7.644  1.00 35.45  ? 326 VAL A CG2 1 
ATOM   2534  N N   . GLN A 1 327 ? -8.812  16.153  -4.554  1.00 38.26  ? 327 GLN A N   1 
ATOM   2535  C CA  . GLN A 1 327 ? -7.818  17.044  -3.981  1.00 41.19  ? 327 GLN A CA  1 
ATOM   2536  C C   . GLN A 1 327 ? -6.761  16.212  -3.273  1.00 38.16  ? 327 GLN A C   1 
ATOM   2537  O O   . GLN A 1 327 ? -5.559  16.421  -3.394  1.00 36.54  ? 327 GLN A O   1 
ATOM   2538  C CB  . GLN A 1 327 ? -8.449  17.961  -2.945  1.00 42.30  ? 327 GLN A CB  1 
ATOM   2539  C CG  . GLN A 1 327 ? -9.187  19.144  -3.534  1.00 58.34  ? 327 GLN A CG  1 
ATOM   2540  C CD  . GLN A 1 327 ? -8.400  20.418  -3.379  1.00 79.64  ? 327 GLN A CD  1 
ATOM   2541  O OE1 . GLN A 1 327 ? -8.066  20.811  -2.247  1.00 80.08  ? 327 GLN A OE1 1 
ATOM   2542  N NE2 . GLN A 1 327 ? -8.087  21.042  -4.515  1.00 83.20  ? 327 GLN A NE2 1 
ATOM   2543  N N   . SER A 1 328 ? -7.251  15.256  -2.506  1.00 36.02  ? 328 SER A N   1 
ATOM   2544  C CA  . SER A 1 328 ? -6.377  14.448  -1.688  1.00 37.29  ? 328 SER A CA  1 
ATOM   2545  C C   . SER A 1 328 ? -5.409  13.639  -2.547  1.00 32.96  ? 328 SER A C   1 
ATOM   2546  O O   . SER A 1 328 ? -4.220  13.513  -2.241  1.00 36.47  ? 328 SER A O   1 
ATOM   2547  C CB  . SER A 1 328 ? -7.203  13.586  -0.818  1.00 39.27  ? 328 SER A CB  1 
ATOM   2548  O OG  . SER A 1 328 ? -6.395  13.160  0.251   1.00 48.88  ? 328 SER A OG  1 
ATOM   2549  N N   . GLN A 1 329 ? -5.904  13.074  -3.637  1.00 31.28  ? 329 GLN A N   1 
ATOM   2550  C CA  . GLN A 1 329 ? -5.034  12.303  -4.501  1.00 32.67  ? 329 GLN A CA  1 
ATOM   2551  C C   . GLN A 1 329 ? -4.024  13.201  -5.212  1.00 35.51  ? 329 GLN A C   1 
ATOM   2552  O O   . GLN A 1 329 ? -2.873  12.795  -5.366  1.00 37.55  ? 329 GLN A O   1 
ATOM   2553  C CB  . GLN A 1 329 ? -5.891  11.518  -5.468  1.00 33.76  ? 329 GLN A CB  1 
ATOM   2554  C CG  . GLN A 1 329 ? -6.648  10.388  -4.782  1.00 38.56  ? 329 GLN A CG  1 
ATOM   2555  C CD  . GLN A 1 329 ? -7.938  10.023  -5.498  1.00 36.67  ? 329 GLN A CD  1 
ATOM   2556  O OE1 . GLN A 1 329 ? -8.497  10.807  -6.258  1.00 37.96  ? 329 GLN A OE1 1 
ATOM   2557  N NE2 . GLN A 1 329 ? -8.414  8.813   -5.292  1.00 36.44  ? 329 GLN A NE2 1 
ATOM   2558  N N   . LEU A 1 330 ? -4.454  14.407  -5.644  1.00 34.03  ? 330 LEU A N   1 
ATOM   2559  C CA  . LEU A 1 330 ? -3.565  15.368  -6.285  1.00 28.89  ? 330 LEU A CA  1 
ATOM   2560  C C   . LEU A 1 330 ? -2.422  15.728  -5.352  1.00 29.96  ? 330 LEU A C   1 
ATOM   2561  O O   . LEU A 1 330 ? -1.229  15.689  -5.716  1.00 27.70  ? 330 LEU A O   1 
ATOM   2562  C CB  . LEU A 1 330 ? -4.362  16.597  -6.674  1.00 30.11  ? 330 LEU A CB  1 
ATOM   2563  C CG  . LEU A 1 330 ? -5.233  16.425  -7.918  1.00 31.84  ? 330 LEU A CG  1 
ATOM   2564  C CD1 . LEU A 1 330 ? -6.167  17.572  -7.891  1.00 33.46  ? 330 LEU A CD1 1 
ATOM   2565  C CD2 . LEU A 1 330 ? -4.454  16.380  -9.224  1.00 29.93  ? 330 LEU A CD2 1 
ATOM   2566  N N   . ALA A 1 331 ? -2.799  16.007  -4.105  1.00 28.58  ? 331 ALA A N   1 
ATOM   2567  C CA  . ALA A 1 331 ? -1.800  16.296  -3.089  1.00 29.54  ? 331 ALA A CA  1 
ATOM   2568  C C   . ALA A 1 331 ? -0.744  15.200  -3.019  1.00 28.65  ? 331 ALA A C   1 
ATOM   2569  O O   . ALA A 1 331 ? 0.426   15.516  -2.917  1.00 30.41  ? 331 ALA A O   1 
ATOM   2570  C CB  . ALA A 1 331 ? -2.451  16.534  -1.769  1.00 32.08  ? 331 ALA A CB  1 
ATOM   2571  N N   . ASP A 1 332 ? -1.136  13.929  -3.138  1.00 31.03  ? 332 ASP A N   1 
ATOM   2572  C CA  . ASP A 1 332 ? -0.171  12.840  -3.123  1.00 32.53  ? 332 ASP A CA  1 
ATOM   2573  C C   . ASP A 1 332 ? 0.625   12.803  -4.429  1.00 31.64  ? 332 ASP A C   1 
ATOM   2574  O O   . ASP A 1 332 ? 1.808   12.455  -4.438  1.00 32.37  ? 332 ASP A O   1 
ATOM   2575  C CB  . ASP A 1 332 ? -0.801  11.489  -2.777  1.00 36.34  ? 332 ASP A CB  1 
ATOM   2576  C CG  . ASP A 1 332 ? -1.199  11.257  -1.312  1.00 41.76  ? 332 ASP A CG  1 
ATOM   2577  O OD1 . ASP A 1 332 ? -0.830  12.048  -0.414  1.00 39.25  ? 332 ASP A OD1 1 
ATOM   2578  O OD2 . ASP A 1 332 ? -1.941  10.310  -1.074  1.00 48.98  ? 332 ASP A OD2 1 
ATOM   2579  N N   . LEU A 1 333 ? 0.035   13.221  -5.546  1.00 31.58  ? 333 LEU A N   1 
ATOM   2580  C CA  . LEU A 1 333 ? 0.871   13.365  -6.726  1.00 28.11  ? 333 LEU A CA  1 
ATOM   2581  C C   . LEU A 1 333 ? 1.882   14.488  -6.526  1.00 29.39  ? 333 LEU A C   1 
ATOM   2582  O O   . LEU A 1 333 ? 3.031   14.395  -6.940  1.00 30.11  ? 333 LEU A O   1 
ATOM   2583  C CB  . LEU A 1 333 ? 0.015   13.594  -7.959  1.00 27.78  ? 333 LEU A CB  1 
ATOM   2584  C CG  . LEU A 1 333 ? -0.803  12.395  -8.413  1.00 28.67  ? 333 LEU A CG  1 
ATOM   2585  C CD1 . LEU A 1 333 ? -1.660  12.765  -9.600  1.00 32.24  ? 333 LEU A CD1 1 
ATOM   2586  C CD2 . LEU A 1 333 ? 0.080   11.228  -8.720  1.00 26.88  ? 333 LEU A CD2 1 
ATOM   2587  N N   . VAL A 1 334 ? 1.475   15.564  -5.861  1.00 31.81  ? 334 VAL A N   1 
ATOM   2588  C CA  . VAL A 1 334 ? 2.420   16.643  -5.630  1.00 31.24  ? 334 VAL A CA  1 
ATOM   2589  C C   . VAL A 1 334 ? 3.553   16.130  -4.760  1.00 30.79  ? 334 VAL A C   1 
ATOM   2590  O O   . VAL A 1 334 ? 4.715   16.360  -5.059  1.00 34.55  ? 334 VAL A O   1 
ATOM   2591  C CB  . VAL A 1 334 ? 1.726   17.844  -4.983  1.00 31.99  ? 334 VAL A CB  1 
ATOM   2592  C CG1 . VAL A 1 334 ? 2.739   18.848  -4.455  1.00 36.49  ? 334 VAL A CG1 1 
ATOM   2593  C CG2 . VAL A 1 334 ? 0.769   18.490  -5.955  1.00 30.18  ? 334 VAL A CG2 1 
ATOM   2594  N N   . ARG A 1 335 ? 3.196   15.359  -3.726  1.00 36.14  ? 335 ARG A N   1 
ATOM   2595  C CA  . ARG A 1 335 ? 4.174   14.808  -2.801  1.00 31.82  ? 335 ARG A CA  1 
ATOM   2596  C C   . ARG A 1 335 ? 5.094   13.837  -3.508  1.00 29.41  ? 335 ARG A C   1 
ATOM   2597  O O   . ARG A 1 335 ? 6.275   13.754  -3.173  1.00 34.44  ? 335 ARG A O   1 
ATOM   2598  C CB  . ARG A 1 335 ? 3.545   14.154  -1.576  1.00 33.12  ? 335 ARG A CB  1 
ATOM   2599  C CG  . ARG A 1 335 ? 4.605   13.596  -0.639  1.00 37.19  ? 335 ARG A CG  1 
ATOM   2600  C CD  . ARG A 1 335 ? 4.109   13.447  0.770   1.00 34.64  ? 335 ARG A CD  1 
ATOM   2601  N NE  . ARG A 1 335 ? 2.776   12.829  0.753   1.00 37.68  ? 335 ARG A NE  1 
ATOM   2602  C CZ  . ARG A 1 335 ? 2.579   11.547  0.978   1.00 36.05  ? 335 ARG A CZ  1 
ATOM   2603  N NH1 . ARG A 1 335 ? 3.611   10.743  1.065   1.00 31.43  ? 335 ARG A NH1 1 
ATOM   2604  N NH2 . ARG A 1 335 ? 1.359   11.068  1.079   1.00 39.30  ? 335 ARG A NH2 1 
ATOM   2605  N N   . PHE A 1 336 ? 4.580   13.116  -4.498  1.00 31.04  ? 336 PHE A N   1 
ATOM   2606  C CA  . PHE A 1 336 ? 5.448   12.211  -5.255  1.00 32.81  ? 336 PHE A CA  1 
ATOM   2607  C C   . PHE A 1 336 ? 6.514   13.026  -5.995  1.00 31.51  ? 336 PHE A C   1 
ATOM   2608  O O   . PHE A 1 336 ? 7.691   12.720  -5.954  1.00 31.32  ? 336 PHE A O   1 
ATOM   2609  C CB  . PHE A 1 336 ? 4.543   11.363  -6.145  1.00 31.31  ? 336 PHE A CB  1 
ATOM   2610  C CG  . PHE A 1 336 ? 5.308   10.434  -7.064  1.00 32.26  ? 336 PHE A CG  1 
ATOM   2611  C CD1 . PHE A 1 336 ? 6.008   9.351   -6.552  1.00 31.59  ? 336 PHE A CD1 1 
ATOM   2612  C CD2 . PHE A 1 336 ? 5.286   10.624  -8.438  1.00 31.29  ? 336 PHE A CD2 1 
ATOM   2613  C CE1 . PHE A 1 336 ? 6.711   8.510   -7.387  1.00 30.70  ? 336 PHE A CE1 1 
ATOM   2614  C CE2 . PHE A 1 336 ? 6.011   9.787   -9.260  1.00 34.62  ? 336 PHE A CE2 1 
ATOM   2615  C CZ  . PHE A 1 336 ? 6.706   8.719   -8.736  1.00 31.96  ? 336 PHE A CZ  1 
ATOM   2616  N N   . ARG A 1 337 ? 6.113   14.144  -6.588  1.00 31.55  ? 337 ARG A N   1 
ATOM   2617  C CA  . ARG A 1 337 ? 7.050   15.003  -7.268  1.00 29.72  ? 337 ARG A CA  1 
ATOM   2618  C C   . ARG A 1 337 ? 8.059   15.560  -6.294  1.00 27.57  ? 337 ARG A C   1 
ATOM   2619  O O   . ARG A 1 337 ? 9.279   15.542  -6.557  1.00 32.25  ? 337 ARG A O   1 
ATOM   2620  C CB  . ARG A 1 337 ? 6.302   16.128  -7.983  1.00 35.20  ? 337 ARG A CB  1 
ATOM   2621  C CG  . ARG A 1 337 ? 7.183   17.026  -8.842  1.00 35.60  ? 337 ARG A CG  1 
ATOM   2622  C CD  . ARG A 1 337 ? 7.635   18.216  -8.095  1.00 32.50  ? 337 ARG A CD  1 
ATOM   2623  N NE  . ARG A 1 337 ? 8.431   19.086  -8.949  1.00 37.81  ? 337 ARG A NE  1 
ATOM   2624  C CZ  . ARG A 1 337 ? 8.346   20.422  -8.991  1.00 41.14  ? 337 ARG A CZ  1 
ATOM   2625  N NH1 . ARG A 1 337 ? 7.592   21.089  -8.126  1.00 37.07  ? 337 ARG A NH1 1 
ATOM   2626  N NH2 . ARG A 1 337 ? 9.023   21.088  -9.923  1.00 37.65  ? 337 ARG A NH2 1 
ATOM   2627  N N   . GLU A 1 338 ? 7.572   16.087  -5.181  1.00 27.22  ? 338 GLU A N   1 
ATOM   2628  C CA  . GLU A 1 338 ? 8.503   16.788  -4.300  1.00 28.32  ? 338 GLU A CA  1 
ATOM   2629  C C   . GLU A 1 338 ? 9.467   15.821  -3.620  1.00 28.59  ? 338 GLU A C   1 
ATOM   2630  O O   . GLU A 1 338 ? 10.589  16.209  -3.302  1.00 35.46  ? 338 GLU A O   1 
ATOM   2631  C CB  . GLU A 1 338 ? 7.812   17.698  -3.287  1.00 28.91  ? 338 GLU A CB  1 
ATOM   2632  C CG  . GLU A 1 338 ? 6.976   18.787  -3.935  1.00 29.95  ? 338 GLU A CG  1 
ATOM   2633  C CD  . GLU A 1 338 ? 7.774   19.818  -4.698  1.00 34.35  ? 338 GLU A CD  1 
ATOM   2634  O OE1 . GLU A 1 338 ? 9.020   19.759  -4.636  1.00 41.61  ? 338 GLU A OE1 1 
ATOM   2635  O OE2 . GLU A 1 338 ? 7.127   20.708  -5.300  1.00 36.01  ? 338 GLU A OE2 1 
ATOM   2636  N N   . THR A 1 339 ? 9.062   14.567  -3.413  1.00 28.69  ? 339 THR A N   1 
ATOM   2637  C CA  . THR A 1 339 ? 9.966   13.545  -2.905  1.00 29.03  ? 339 THR A CA  1 
ATOM   2638  C C   . THR A 1 339 ? 11.137  13.342  -3.861  1.00 28.76  ? 339 THR A C   1 
ATOM   2639  O O   . THR A 1 339 ? 12.299  13.344  -3.461  1.00 32.74  ? 339 THR A O   1 
ATOM   2640  C CB  . THR A 1 339 ? 9.202   12.236  -2.650  1.00 29.96  ? 339 THR A CB  1 
ATOM   2641  O OG1 . THR A 1 339 ? 8.141   12.511  -1.746  1.00 31.95  ? 339 THR A OG1 1 
ATOM   2642  C CG2 . THR A 1 339 ? 10.036  11.245  -1.870  1.00 29.92  ? 339 THR A CG2 1 
ATOM   2643  N N   . CYS A 1 340 ? 10.859  13.139  -5.142  1.00 30.52  ? 340 CYS A N   1 
ATOM   2644  C CA  . CYS A 1 340 ? 11.932  12.941  -6.111  1.00 30.52  ? 340 CYS A CA  1 
ATOM   2645  C C   . CYS A 1 340 ? 12.832  14.173  -6.148  1.00 30.86  ? 340 CYS A C   1 
ATOM   2646  O O   . CYS A 1 340 ? 14.054  14.094  -6.058  1.00 31.97  ? 340 CYS A O   1 
ATOM   2647  C CB  . CYS A 1 340 ? 11.355  12.659  -7.489  1.00 35.50  ? 340 CYS A CB  1 
ATOM   2648  S SG  . CYS A 1 340 ? 10.405  11.123  -7.583  1.00 34.67  ? 340 CYS A SG  1 
ATOM   2649  N N   . LYS A 1 341 ? 12.216  15.348  -6.153  1.00 32.28  ? 341 LYS A N   1 
ATOM   2650  C CA  . LYS A 1 341 ? 13.005  16.570  -6.172  1.00 35.73  ? 341 LYS A CA  1 
ATOM   2651  C C   . LYS A 1 341 ? 13.903  16.678  -4.932  1.00 36.58  ? 341 LYS A C   1 
ATOM   2652  O O   . LYS A 1 341 ? 15.076  17.035  -5.039  1.00 34.49  ? 341 LYS A O   1 
ATOM   2653  C CB  . LYS A 1 341 ? 12.038  17.731  -6.396  1.00 35.40  ? 341 LYS A CB  1 
ATOM   2654  C CG  . LYS A 1 341 ? 12.716  19.045  -6.590  1.00 38.53  ? 341 LYS A CG  1 
ATOM   2655  C CD  . LYS A 1 341 ? 11.809  20.077  -7.218  1.00 36.02  ? 341 LYS A CD  1 
ATOM   2656  C CE  . LYS A 1 341 ? 12.602  21.336  -7.333  1.00 36.25  ? 341 LYS A CE  1 
ATOM   2657  N NZ  . LYS A 1 341 ? 11.617  22.407  -7.430  1.00 37.36  ? 341 LYS A NZ  1 
ATOM   2658  N N   . ALA A 1 342 ? 13.373  16.337  -3.753  1.00 35.66  ? 342 ALA A N   1 
ATOM   2659  C CA  . ALA A 1 342 ? 14.156  16.423  -2.522  1.00 33.62  ? 342 ALA A CA  1 
ATOM   2660  C C   . ALA A 1 342 ? 15.341  15.469  -2.533  1.00 34.70  ? 342 ALA A C   1 
ATOM   2661  O O   . ALA A 1 342 ? 16.400  15.811  -2.003  1.00 33.49  ? 342 ALA A O   1 
ATOM   2662  C CB  . ALA A 1 342 ? 13.300  16.152  -1.305  1.00 31.87  ? 342 ALA A CB  1 
ATOM   2663  N N   . PHE A 1 343 ? 15.167  14.247  -3.068  1.00 33.38  ? 343 PHE A N   1 
ATOM   2664  C CA  . PHE A 1 343 ? 16.303  13.354  -3.123  1.00 28.34  ? 343 PHE A CA  1 
ATOM   2665  C C   . PHE A 1 343 ? 17.374  13.928  -4.057  1.00 30.43  ? 343 PHE A C   1 
ATOM   2666  O O   . PHE A 1 343 ? 18.561  13.845  -3.773  1.00 36.45  ? 343 PHE A O   1 
ATOM   2667  C CB  . PHE A 1 343 ? 15.889  11.963  -3.574  1.00 31.76  ? 343 PHE A CB  1 
ATOM   2668  C CG  . PHE A 1 343 ? 15.492  11.015  -2.470  1.00 29.57  ? 343 PHE A CG  1 
ATOM   2669  C CD1 . PHE A 1 343 ? 16.452  10.465  -1.640  1.00 30.22  ? 343 PHE A CD1 1 
ATOM   2670  C CD2 . PHE A 1 343 ? 14.166  10.703  -2.249  1.00 28.68  ? 343 PHE A CD2 1 
ATOM   2671  C CE1 . PHE A 1 343 ? 16.086  9.580   -0.644  1.00 30.29  ? 343 PHE A CE1 1 
ATOM   2672  C CE2 . PHE A 1 343 ? 13.815  9.791   -1.274  1.00 27.62  ? 343 PHE A CE2 1 
ATOM   2673  C CZ  . PHE A 1 343 ? 14.764  9.234   -0.481  1.00 28.42  ? 343 PHE A CZ  1 
ATOM   2674  N N   . ALA A 1 344 ? 16.967  14.530  -5.172  1.00 33.75  ? 344 ALA A N   1 
ATOM   2675  C CA  . ALA A 1 344 ? 17.921  15.152  -6.080  1.00 34.32  ? 344 ALA A CA  1 
ATOM   2676  C C   . ALA A 1 344 ? 18.686  16.289  -5.411  1.00 32.25  ? 344 ALA A C   1 
ATOM   2677  O O   . ALA A 1 344 ? 19.905  16.389  -5.568  1.00 34.07  ? 344 ALA A O   1 
ATOM   2678  C CB  . ALA A 1 344 ? 17.215  15.651  -7.307  1.00 39.37  ? 344 ALA A CB  1 
ATOM   2679  N N   . ILE A 1 345 ? 17.990  17.123  -4.648  1.00 32.15  ? 345 ILE A N   1 
ATOM   2680  C CA  . ILE A 1 345 ? 18.653  18.194  -3.912  1.00 34.23  ? 345 ILE A CA  1 
ATOM   2681  C C   . ILE A 1 345 ? 19.570  17.627  -2.837  1.00 37.80  ? 345 ILE A C   1 
ATOM   2682  O O   . ILE A 1 345 ? 20.702  18.089  -2.672  1.00 37.52  ? 345 ILE A O   1 
ATOM   2683  C CB  . ILE A 1 345 ? 17.641  19.175  -3.325  1.00 36.89  ? 345 ILE A CB  1 
ATOM   2684  C CG1 . ILE A 1 345 ? 17.010  19.996  -4.425  1.00 36.56  ? 345 ILE A CG1 1 
ATOM   2685  C CG2 . ILE A 1 345 ? 18.303  20.065  -2.285  1.00 43.20  ? 345 ILE A CG2 1 
ATOM   2686  C CD1 . ILE A 1 345 ? 15.692  20.618  -4.042  1.00 39.07  ? 345 ILE A CD1 1 
ATOM   2687  N N   . ALA A 1 346 ? 19.120  16.599  -2.114  1.00 39.80  ? 346 ALA A N   1 
ATOM   2688  C CA  . ALA A 1 346 ? 19.953  16.078  -1.039  1.00 33.72  ? 346 ALA A CA  1 
ATOM   2689  C C   . ALA A 1 346 ? 21.202  15.425  -1.612  1.00 33.08  ? 346 ALA A C   1 
ATOM   2690  O O   . ALA A 1 346 ? 22.267  15.437  -0.992  1.00 33.97  ? 346 ALA A O   1 
ATOM   2691  C CB  . ALA A 1 346 ? 19.178  15.116  -0.187  1.00 33.79  ? 346 ALA A CB  1 
ATOM   2692  N N   . ALA A 1 347 ? 21.054  14.816  -2.792  1.00 34.30  ? 347 ALA A N   1 
ATOM   2693  C CA  . ALA A 1 347 ? 22.172  14.138  -3.409  1.00 33.75  ? 347 ALA A CA  1 
ATOM   2694  C C   . ALA A 1 347 ? 23.242  15.155  -3.789  1.00 34.88  ? 347 ALA A C   1 
ATOM   2695  O O   . ALA A 1 347 ? 24.413  14.955  -3.521  1.00 36.02  ? 347 ALA A O   1 
ATOM   2696  C CB  . ALA A 1 347 ? 21.717  13.361  -4.599  1.00 35.11  ? 347 ALA A CB  1 
ATOM   2697  N N   . GLU A 1 348 ? 22.838  16.230  -4.448  1.00 36.52  ? 348 GLU A N   1 
ATOM   2698  C CA  . GLU A 1 348 ? 23.784  17.248  -4.873  1.00 36.58  ? 348 GLU A CA  1 
ATOM   2699  C C   . GLU A 1 348 ? 24.431  17.883  -3.656  1.00 35.80  ? 348 GLU A C   1 
ATOM   2700  O O   . GLU A 1 348 ? 25.645  17.936  -3.542  1.00 44.06  ? 348 GLU A O   1 
ATOM   2701  C CB  . GLU A 1 348 ? 23.057  18.319  -5.666  1.00 37.60  ? 348 GLU A CB  1 
ATOM   2702  C CG  . GLU A 1 348 ? 24.002  19.247  -6.416  1.00 39.23  ? 348 GLU A CG  1 
ATOM   2703  C CD  . GLU A 1 348 ? 23.175  20.005  -7.415  1.00 40.59  ? 348 GLU A CD  1 
ATOM   2704  O OE1 . GLU A 1 348 ? 22.818  19.413  -8.489  1.00 35.31  ? 348 GLU A OE1 1 
ATOM   2705  O OE2 . GLU A 1 348 ? 22.836  21.157  -7.023  1.00 36.18  ? 348 GLU A OE2 1 
ATOM   2706  N N   . GLU A 1 349 ? 23.601  18.255  -2.703  1.00 35.78  ? 349 GLU A N   1 
ATOM   2707  C CA  . GLU A 1 349 ? 24.046  18.977  -1.529  1.00 38.91  ? 349 GLU A CA  1 
ATOM   2708  C C   . GLU A 1 349 ? 25.014  18.169  -0.671  1.00 40.50  ? 349 GLU A C   1 
ATOM   2709  O O   . GLU A 1 349 ? 25.815  18.759  0.027   1.00 39.52  ? 349 GLU A O   1 
ATOM   2710  C CB  . GLU A 1 349 ? 22.832  19.377  -0.699  1.00 41.11  ? 349 GLU A CB  1 
ATOM   2711  C CG  . GLU A 1 349 ? 23.198  19.944  0.662   1.00 48.11  ? 349 GLU A CG  1 
ATOM   2712  C CD  . GLU A 1 349 ? 24.086  21.182  0.643   1.00 54.80  ? 349 GLU A CD  1 
ATOM   2713  O OE1 . GLU A 1 349 ? 24.324  21.793  -0.435  1.00 57.61  ? 349 GLU A OE1 1 
ATOM   2714  O OE2 . GLU A 1 349 ? 24.515  21.528  1.761   1.00 47.13  ? 349 GLU A OE2 1 
ATOM   2715  N N   . THR A 1 350 ? 24.956  16.835  -0.680  1.00 39.28  ? 350 THR A N   1 
ATOM   2716  C CA  . THR A 1 350 ? 25.882  16.080  0.145   1.00 34.28  ? 350 THR A CA  1 
ATOM   2717  C C   . THR A 1 350 ? 26.910  15.359  -0.714  1.00 33.24  ? 350 THR A C   1 
ATOM   2718  O O   . THR A 1 350 ? 27.479  14.362  -0.287  1.00 35.55  ? 350 THR A O   1 
ATOM   2719  C CB  . THR A 1 350 ? 25.068  15.092  0.987   1.00 40.62  ? 350 THR A CB  1 
ATOM   2720  O OG1 . THR A 1 350 ? 24.379  14.210  0.095   1.00 38.63  ? 350 THR A OG1 1 
ATOM   2721  C CG2 . THR A 1 350 ? 24.089  15.817  1.898   1.00 35.78  ? 350 THR A CG2 1 
ATOM   2722  N N   . GLY A 1 351 ? 27.128  15.826  -1.943  1.00 38.08  ? 351 GLY A N   1 
ATOM   2723  C CA  . GLY A 1 351 ? 28.139  15.223  -2.795  1.00 42.33  ? 351 GLY A CA  1 
ATOM   2724  C C   . GLY A 1 351 ? 29.545  15.569  -2.315  1.00 40.72  ? 351 GLY A C   1 
ATOM   2725  O O   . GLY A 1 351 ? 29.707  16.335  -1.379  1.00 41.26  ? 351 GLY A O   1 
ATOM   2726  N N   . PHE A 1 352 ? 30.545  15.012  -2.988  1.00 46.41  ? 352 PHE A N   1 
ATOM   2727  C CA  . PHE A 1 352 ? 31.939  15.144  -2.595  1.00 54.66  ? 352 PHE A CA  1 
ATOM   2728  C C   . PHE A 1 352 ? 32.805  14.970  -3.848  1.00 49.34  ? 352 PHE A C   1 
ATOM   2729  O O   . PHE A 1 352 ? 32.338  14.445  -4.857  1.00 44.00  ? 352 PHE A O   1 
ATOM   2730  C CB  . PHE A 1 352 ? 32.171  14.074  -1.522  1.00 62.03  ? 352 PHE A CB  1 
ATOM   2731  C CG  . PHE A 1 352 ? 31.919  12.689  -2.102  1.00 72.93  ? 352 PHE A CG  1 
ATOM   2732  C CD1 . PHE A 1 352 ? 30.637  12.136  -2.096  1.00 84.39  ? 352 PHE A CD1 1 
ATOM   2733  C CD2 . PHE A 1 352 ? 32.939  11.992  -2.751  1.00 83.67  ? 352 PHE A CD2 1 
ATOM   2734  C CE1 . PHE A 1 352 ? 30.393  10.901  -2.686  1.00 90.29  ? 352 PHE A CE1 1 
ATOM   2735  C CE2 . PHE A 1 352 ? 32.695  10.754  -3.342  1.00 93.24  ? 352 PHE A CE2 1 
ATOM   2736  C CZ  . PHE A 1 352 ? 31.425  10.205  -3.300  1.00 98.48  ? 352 PHE A CZ  1 
ATOM   2737  N N   . THR A 1 353 ? 34.078  15.369  -3.799  1.00 47.22  ? 353 THR A N   1 
ATOM   2738  C CA  . THR A 1 353 ? 34.904  15.271  -4.992  1.00 48.61  ? 353 THR A CA  1 
ATOM   2739  C C   . THR A 1 353 ? 35.595  13.923  -4.959  1.00 43.46  ? 353 THR A C   1 
ATOM   2740  O O   . THR A 1 353 ? 35.956  13.480  -3.894  1.00 48.97  ? 353 THR A O   1 
ATOM   2741  C CB  . THR A 1 353 ? 35.875  16.444  -5.081  1.00 50.51  ? 353 THR A CB  1 
ATOM   2742  O OG1 . THR A 1 353 ? 36.414  16.550  -3.775  1.00 55.49  ? 353 THR A OG1 1 
ATOM   2743  C CG2 . THR A 1 353 ? 35.195  17.765  -5.404  1.00 49.69  ? 353 THR A CG2 1 
ATOM   2744  N N   . THR A 1 354 ? 35.732  13.265  -6.110  1.00 46.03  ? 354 THR A N   1 
ATOM   2745  C CA  . THR A 1 354 ? 36.561  12.069  -6.246  1.00 60.07  ? 354 THR A CA  1 
ATOM   2746  C C   . THR A 1 354 ? 38.036  12.402  -5.996  1.00 59.25  ? 354 THR A C   1 
ATOM   2747  O O   . THR A 1 354 ? 38.393  13.562  -5.829  1.00 55.90  ? 354 THR A O   1 
ATOM   2748  C CB  . THR A 1 354 ? 36.398  11.510  -7.656  1.00 67.05  ? 354 THR A CB  1 
ATOM   2749  O OG1 . THR A 1 354 ? 35.040  11.769  -7.981  1.00 72.52  ? 354 THR A OG1 1 
ATOM   2750  C CG2 . THR A 1 354 ? 36.629  10.012  -7.717  1.00 81.31  ? 354 THR A CG2 1 
ATOM   2751  N N   . ALA A 1 355 ? 38.917  11.397  -5.992  1.00 58.61  ? 355 ALA A N   1 
ATOM   2752  C CA  . ALA A 1 355 ? 40.351  11.686  -5.975  1.00 67.48  ? 355 ALA A CA  1 
ATOM   2753  C C   . ALA A 1 355 ? 40.762  12.517  -7.194  1.00 64.76  ? 355 ALA A C   1 
ATOM   2754  O O   . ALA A 1 355 ? 41.518  13.478  -7.057  1.00 66.71  ? 355 ALA A O   1 
ATOM   2755  C CB  . ALA A 1 355 ? 41.155  10.414  -5.896  1.00 69.58  ? 355 ALA A CB  1 
ATOM   2756  N N   . GLY A 1 356 ? 40.206  12.185  -8.368  1.00 50.96  ? 356 GLY A N   1 
ATOM   2757  C CA  . GLY A 1 356 ? 40.504  12.892  -9.604  1.00 48.64  ? 356 GLY A CA  1 
ATOM   2758  C C   . GLY A 1 356 ? 39.967  14.324  -9.672  1.00 44.80  ? 356 GLY A C   1 
ATOM   2759  O O   . GLY A 1 356 ? 40.267  15.045  -10.621 1.00 49.11  ? 356 GLY A O   1 
ATOM   2760  N N   . GLY A 1 357 ? 39.167  14.746  -8.688  1.00 45.49  ? 357 GLY A N   1 
ATOM   2761  C CA  . GLY A 1 357 ? 38.623  16.098  -8.660  1.00 43.68  ? 357 GLY A CA  1 
ATOM   2762  C C   . GLY A 1 357 ? 37.216  16.182  -9.268  1.00 42.67  ? 357 GLY A C   1 
ATOM   2763  O O   . GLY A 1 357 ? 36.735  17.279  -9.566  1.00 40.36  ? 357 GLY A O   1 
ATOM   2764  N N   . LEU A 1 358 ? 36.554  15.036  -9.469  1.00 40.99  ? 358 LEU A N   1 
ATOM   2765  C CA  . LEU A 1 358 ? 35.193  15.054  -9.989  1.00 46.44  ? 358 LEU A CA  1 
ATOM   2766  C C   . LEU A 1 358 ? 34.236  15.282  -8.829  1.00 41.31  ? 358 LEU A C   1 
ATOM   2767  O O   . LEU A 1 358 ? 34.372  14.610  -7.809  1.00 47.78  ? 358 LEU A O   1 
ATOM   2768  C CB  . LEU A 1 358 ? 34.955  13.703  -10.648 1.00 50.88  ? 358 LEU A CB  1 
ATOM   2769  C CG  . LEU A 1 358 ? 33.922  13.670  -11.774 1.00 60.03  ? 358 LEU A CG  1 
ATOM   2770  C CD1 . LEU A 1 358 ? 34.325  14.549  -12.938 1.00 67.47  ? 358 LEU A CD1 1 
ATOM   2771  C CD2 . LEU A 1 358 ? 33.755  12.230  -12.230 1.00 63.62  ? 358 LEU A CD2 1 
ATOM   2772  N N   . PHE A 1 359 ? 33.325  16.254  -8.944  1.00 42.26  ? 359 PHE A N   1 
ATOM   2773  C CA  . PHE A 1 359 ? 32.280  16.438  -7.936  1.00 45.45  ? 359 PHE A CA  1 
ATOM   2774  C C   . PHE A 1 359 ? 31.076  15.570  -8.284  1.00 46.09  ? 359 PHE A C   1 
ATOM   2775  O O   . PHE A 1 359 ? 30.454  15.759  -9.326  1.00 44.01  ? 359 PHE A O   1 
ATOM   2776  C CB  . PHE A 1 359 ? 31.726  17.849  -7.753  1.00 48.09  ? 359 PHE A CB  1 
ATOM   2777  C CG  . PHE A 1 359 ? 30.725  18.002  -6.615  1.00 44.36  ? 359 PHE A CG  1 
ATOM   2778  C CD1 . PHE A 1 359 ? 29.371  17.807  -6.828  1.00 42.82  ? 359 PHE A CD1 1 
ATOM   2779  C CD2 . PHE A 1 359 ? 31.147  18.361  -5.337  1.00 42.68  ? 359 PHE A CD2 1 
ATOM   2780  C CE1 . PHE A 1 359 ? 28.460  17.982  -5.797  1.00 43.49  ? 359 PHE A CE1 1 
ATOM   2781  C CE2 . PHE A 1 359 ? 30.243  18.517  -4.305  1.00 42.48  ? 359 PHE A CE2 1 
ATOM   2782  C CZ  . PHE A 1 359 ? 28.894  18.344  -4.543  1.00 46.71  ? 359 PHE A CZ  1 
ATOM   2783  N N   . LYS A 1 360 ? 30.796  14.627  -7.382  1.00 46.24  ? 360 LYS A N   1 
ATOM   2784  C CA  . LYS A 1 360 ? 29.860  13.539  -7.584  1.00 47.65  ? 360 LYS A CA  1 
ATOM   2785  C C   . LYS A 1 360 ? 28.751  13.635  -6.542  1.00 45.36  ? 360 LYS A C   1 
ATOM   2786  O O   . LYS A 1 360 ? 29.004  13.561  -5.338  1.00 42.49  ? 360 LYS A O   1 
ATOM   2787  C CB  . LYS A 1 360 ? 30.621  12.233  -7.348  1.00 48.98  ? 360 LYS A CB  1 
ATOM   2788  C CG  . LYS A 1 360 ? 29.950  10.937  -7.792  1.00 52.90  ? 360 LYS A CG  1 
ATOM   2789  C CD  . LYS A 1 360 ? 30.673  9.756   -7.151  1.00 57.96  ? 360 LYS A CD  1 
ATOM   2790  C CE  . LYS A 1 360 ? 29.954  8.462   -7.248  1.00 61.88  ? 360 LYS A CE  1 
ATOM   2791  N NZ  . LYS A 1 360 ? 30.093  7.891   -8.587  1.00 67.31  ? 360 LYS A NZ  1 
ATOM   2792  N N   . PRO A 1 361 ? 27.498  13.855  -6.968  1.00 37.58  ? 361 PRO A N   1 
ATOM   2793  C CA  . PRO A 1 361 ? 26.338  13.678  -6.097  1.00 37.05  ? 361 PRO A CA  1 
ATOM   2794  C C   . PRO A 1 361 ? 26.389  12.413  -5.249  1.00 37.58  ? 361 PRO A C   1 
ATOM   2795  O O   . PRO A 1 361 ? 26.928  11.416  -5.700  1.00 39.41  ? 361 PRO A O   1 
ATOM   2796  C CB  . PRO A 1 361 ? 25.211  13.620  -7.116  1.00 37.05  ? 361 PRO A CB  1 
ATOM   2797  C CG  . PRO A 1 361 ? 25.647  14.622  -8.161  1.00 41.68  ? 361 PRO A CG  1 
ATOM   2798  C CD  . PRO A 1 361 ? 27.143  14.371  -8.291  1.00 40.67  ? 361 PRO A CD  1 
ATOM   2799  N N   . ASN A 1 362 ? 25.792  12.465  -4.040  1.00 37.87  ? 362 ASN A N   1 
ATOM   2800  C CA  . ASN A 1 362 ? 25.780  11.335  -3.126  1.00 36.21  ? 362 ASN A CA  1 
ATOM   2801  C C   . ASN A 1 362 ? 24.882  10.217  -3.661  1.00 36.96  ? 362 ASN A C   1 
ATOM   2802  O O   . ASN A 1 362 ? 23.663  10.358  -3.717  1.00 38.53  ? 362 ASN A O   1 
ATOM   2803  C CB  . ASN A 1 362 ? 25.315  11.823  -1.767  1.00 37.79  ? 362 ASN A CB  1 
ATOM   2804  C CG  . ASN A 1 362 ? 25.471  10.816  -0.663  1.00 38.29  ? 362 ASN A CG  1 
ATOM   2805  O OD1 . ASN A 1 362 ? 25.749  9.636   -0.868  1.00 39.81  ? 362 ASN A OD1 1 
ATOM   2806  N ND2 . ASN A 1 362 ? 25.241  11.282  0.544   1.00 46.64  ? 362 ASN A ND2 1 
ATOM   2807  N N   . ASN A 1 363 ? 25.475  9.074   -4.004  1.00 34.00  ? 363 ASN A N   1 
ATOM   2808  C CA  . ASN A 1 363 ? 24.715  7.991   -4.607  1.00 35.07  ? 363 ASN A CA  1 
ATOM   2809  C C   . ASN A 1 363 ? 23.655  7.416   -3.651  1.00 35.87  ? 363 ASN A C   1 
ATOM   2810  O O   . ASN A 1 363 ? 22.692  6.798   -4.098  1.00 38.35  ? 363 ASN A O   1 
ATOM   2811  C CB  . ASN A 1 363 ? 25.634  6.919   -5.177  1.00 37.12  ? 363 ASN A CB  1 
ATOM   2812  C CG  . ASN A 1 363 ? 26.550  6.335   -4.131  1.00 49.13  ? 363 ASN A CG  1 
ATOM   2813  O OD1 . ASN A 1 363 ? 26.364  6.611   -2.944  1.00 52.74  ? 363 ASN A OD1 1 
ATOM   2814  N ND2 . ASN A 1 363 ? 27.549  5.568   -4.545  1.00 54.62  ? 363 ASN A ND2 1 
ATOM   2815  N N   . ILE A 1 364 ? 23.811  7.594   -2.337  1.00 34.38  ? 364 ILE A N   1 
ATOM   2816  C CA  . ILE A 1 364 ? 22.795  7.128   -1.414  1.00 36.11  ? 364 ILE A CA  1 
ATOM   2817  C C   . ILE A 1 364 ? 21.463  7.822   -1.678  1.00 32.79  ? 364 ILE A C   1 
ATOM   2818  O O   . ILE A 1 364 ? 20.437  7.179   -1.804  1.00 35.19  ? 364 ILE A O   1 
ATOM   2819  C CB  . ILE A 1 364 ? 23.251  7.310   0.033   1.00 44.71  ? 364 ILE A CB  1 
ATOM   2820  C CG1 . ILE A 1 364 ? 24.352  6.275   0.350   1.00 50.19  ? 364 ILE A CG1 1 
ATOM   2821  C CG2 . ILE A 1 364 ? 22.047  7.215   0.971   1.00 44.54  ? 364 ILE A CG2 1 
ATOM   2822  C CD1 . ILE A 1 364 ? 24.870  6.314   1.770   1.00 50.29  ? 364 ILE A CD1 1 
ATOM   2823  N N   . TYR A 1 365 ? 21.464  9.133   -1.794  1.00 33.08  ? 365 TYR A N   1 
ATOM   2824  C CA  . TYR A 1 365 ? 20.233  9.817   -2.111  1.00 32.59  ? 365 TYR A CA  1 
ATOM   2825  C C   . TYR A 1 365 ? 19.834  9.585   -3.554  1.00 35.53  ? 365 TYR A C   1 
ATOM   2826  O O   . TYR A 1 365 ? 18.644  9.506   -3.839  1.00 37.92  ? 365 TYR A O   1 
ATOM   2827  C CB  . TYR A 1 365 ? 20.370  11.295  -1.781  1.00 38.12  ? 365 TYR A CB  1 
ATOM   2828  C CG  . TYR A 1 365 ? 20.537  11.472  -0.286  1.00 38.50  ? 365 TYR A CG  1 
ATOM   2829  C CD1 . TYR A 1 365 ? 19.500  11.178  0.585   1.00 36.22  ? 365 TYR A CD1 1 
ATOM   2830  C CD2 . TYR A 1 365 ? 21.746  11.883  0.245   1.00 39.58  ? 365 TYR A CD2 1 
ATOM   2831  C CE1 . TYR A 1 365 ? 19.659  11.322  1.953   1.00 40.33  ? 365 TYR A CE1 1 
ATOM   2832  C CE2 . TYR A 1 365 ? 21.898  12.082  1.604   1.00 42.00  ? 365 TYR A CE2 1 
ATOM   2833  C CZ  . TYR A 1 365 ? 20.858  11.782  2.461   1.00 42.20  ? 365 TYR A CZ  1 
ATOM   2834  O OH  . TYR A 1 365 ? 21.055  11.953  3.792   1.00 51.09  ? 365 TYR A OH  1 
ATOM   2835  N N   . VAL A 1 366 ? 20.796  9.422   -4.462  1.00 35.86  ? 366 VAL A N   1 
ATOM   2836  C CA  . VAL A 1 366 ? 20.403  9.152   -5.831  1.00 34.15  ? 366 VAL A CA  1 
ATOM   2837  C C   . VAL A 1 366 ? 19.646  7.824   -5.889  1.00 33.05  ? 366 VAL A C   1 
ATOM   2838  O O   . VAL A 1 366 ? 18.579  7.760   -6.492  1.00 30.57  ? 366 VAL A O   1 
ATOM   2839  C CB  . VAL A 1 366 ? 21.569  9.186   -6.830  1.00 35.31  ? 366 VAL A CB  1 
ATOM   2840  C CG1 . VAL A 1 366 ? 21.136  8.864   -8.248  1.00 35.22  ? 366 VAL A CG1 1 
ATOM   2841  C CG2 . VAL A 1 366 ? 22.240  10.543  -6.850  1.00 37.28  ? 366 VAL A CG2 1 
ATOM   2842  N N   . ASP A 1 367 ? 20.202  6.752   -5.325  1.00 30.42  ? 367 ASP A N   1 
ATOM   2843  C CA  . ASP A 1 367 ? 19.602  5.432   -5.495  1.00 31.73  ? 367 ASP A CA  1 
ATOM   2844  C C   . ASP A 1 367 ? 18.306  5.284   -4.703  1.00 35.86  ? 367 ASP A C   1 
ATOM   2845  O O   . ASP A 1 367 ? 17.381  4.593   -5.140  1.00 38.54  ? 367 ASP A O   1 
ATOM   2846  C CB  . ASP A 1 367 ? 20.573  4.338   -5.111  1.00 34.57  ? 367 ASP A CB  1 
ATOM   2847  C CG  . ASP A 1 367 ? 21.783  4.258   -6.038  1.00 43.33  ? 367 ASP A CG  1 
ATOM   2848  O OD1 . ASP A 1 367 ? 21.687  4.779   -7.167  1.00 42.65  ? 367 ASP A OD1 1 
ATOM   2849  O OD2 . ASP A 1 367 ? 22.820  3.718   -5.603  1.00 52.82  ? 367 ASP A OD2 1 
ATOM   2850  N N   . LEU A 1 368 ? 18.232  5.936   -3.538  1.00 31.63  ? 368 LEU A N   1 
ATOM   2851  C CA  . LEU A 1 368 ? 17.049  5.802   -2.736  1.00 32.99  ? 368 LEU A CA  1 
ATOM   2852  C C   . LEU A 1 368 ? 15.952  6.650   -3.349  1.00 29.53  ? 368 LEU A C   1 
ATOM   2853  O O   . LEU A 1 368 ? 14.820  6.246   -3.281  1.00 31.85  ? 368 LEU A O   1 
ATOM   2854  C CB  . LEU A 1 368 ? 17.287  6.020   -1.244  1.00 33.56  ? 368 LEU A CB  1 
ATOM   2855  C CG  . LEU A 1 368 ? 18.292  5.029   -0.640  1.00 37.57  ? 368 LEU A CG  1 
ATOM   2856  C CD1 . LEU A 1 368 ? 18.475  5.237   0.844   1.00 41.93  ? 368 LEU A CD1 1 
ATOM   2857  C CD2 . LEU A 1 368 ? 17.923  3.600   -0.894  1.00 39.80  ? 368 LEU A CD2 1 
ATOM   2858  N N   . GLY A 1 369 ? 16.293  7.730   -4.034  1.00 33.05  ? 369 GLY A N   1 
ATOM   2859  C CA  . GLY A 1 369 ? 15.328  8.507   -4.785  1.00 32.95  ? 369 GLY A CA  1 
ATOM   2860  C C   . GLY A 1 369 ? 14.808  7.719   -5.978  1.00 36.24  ? 369 GLY A C   1 
ATOM   2861  O O   . GLY A 1 369 ? 13.602  7.667   -6.257  1.00 34.90  ? 369 GLY A O   1 
ATOM   2862  N N   . ARG A 1 370 ? 15.722  7.042   -6.661  1.00 35.19  ? 370 ARG A N   1 
ATOM   2863  C CA  . ARG A 1 370 ? 15.283  6.144   -7.720  1.00 35.81  ? 370 ARG A CA  1 
ATOM   2864  C C   . ARG A 1 370 ? 14.303  5.136   -7.147  1.00 30.04  ? 370 ARG A C   1 
ATOM   2865  O O   . ARG A 1 370 ? 13.264  4.912   -7.715  1.00 31.74  ? 370 ARG A O   1 
ATOM   2866  C CB  . ARG A 1 370 ? 16.439  5.447   -8.437  1.00 35.76  ? 370 ARG A CB  1 
ATOM   2867  C CG  . ARG A 1 370 ? 17.154  6.409   -9.383  1.00 41.32  ? 370 ARG A CG  1 
ATOM   2868  C CD  . ARG A 1 370 ? 18.508  5.889   -9.832  1.00 40.00  ? 370 ARG A CD  1 
ATOM   2869  N NE  . ARG A 1 370 ? 18.180  4.642   -10.496 1.00 44.42  ? 370 ARG A NE  1 
ATOM   2870  C CZ  . ARG A 1 370 ? 18.493  3.443   -10.063 1.00 48.57  ? 370 ARG A CZ  1 
ATOM   2871  N NH1 . ARG A 1 370 ? 19.407  3.260   -9.110  1.00 50.60  ? 370 ARG A NH1 1 
ATOM   2872  N NH2 . ARG A 1 370 ? 17.923  2.433   -10.677 1.00 40.87  ? 370 ARG A NH2 1 
ATOM   2873  N N   . ALA A 1 371 ? 14.655  4.516   -6.035  1.00 31.01  ? 371 ALA A N   1 
ATOM   2874  C CA  . ALA A 1 371 ? 13.839  3.473   -5.453  1.00 29.51  ? 371 ALA A CA  1 
ATOM   2875  C C   . ALA A 1 371 ? 12.437  4.004   -5.175  1.00 30.92  ? 371 ALA A C   1 
ATOM   2876  O O   . ALA A 1 371 ? 11.451  3.294   -5.345  1.00 34.31  ? 371 ALA A O   1 
ATOM   2877  C CB  . ALA A 1 371 ? 14.495  2.995   -4.190  1.00 30.17  ? 371 ALA A CB  1 
ATOM   2878  N N   . HIS A 1 372 ? 12.351  5.246   -4.692  1.00 32.97  ? 372 HIS A N   1 
ATOM   2879  C CA  . HIS A 1 372 ? 11.068  5.853   -4.368  1.00 31.42  ? 372 HIS A CA  1 
ATOM   2880  C C   . HIS A 1 372 ? 10.216  5.989   -5.628  1.00 30.08  ? 372 HIS A C   1 
ATOM   2881  O O   . HIS A 1 372 ? 9.020   5.738   -5.584  1.00 29.82  ? 372 HIS A O   1 
ATOM   2882  C CB  . HIS A 1 372 ? 11.233  7.245   -3.765  1.00 29.63  ? 372 HIS A CB  1 
ATOM   2883  C CG  . HIS A 1 372 ? 9.917   7.783   -3.326  1.00 31.35  ? 372 HIS A CG  1 
ATOM   2884  N ND1 . HIS A 1 372 ? 9.078   8.547   -4.106  1.00 32.42  ? 372 HIS A ND1 1 
ATOM   2885  C CD2 . HIS A 1 372 ? 9.268   7.569   -2.181  1.00 33.38  ? 372 HIS A CD2 1 
ATOM   2886  C CE1 . HIS A 1 372 ? 7.982   8.804   -3.417  1.00 32.64  ? 372 HIS A CE1 1 
ATOM   2887  N NE2 . HIS A 1 372 ? 8.083   8.220   -2.251  1.00 31.76  ? 372 HIS A NE2 1 
ATOM   2888  N N   . TYR A 1 373 ? 10.839  6.465   -6.708  1.00 30.88  ? 373 TYR A N   1 
ATOM   2889  C CA  . TYR A 1 373 ? 10.210  6.527   -8.013  1.00 33.11  ? 373 TYR A CA  1 
ATOM   2890  C C   . TYR A 1 373 ? 9.799   5.134   -8.445  1.00 29.41  ? 373 TYR A C   1 
ATOM   2891  O O   . TYR A 1 373 ? 8.651   4.917   -8.791  1.00 31.65  ? 373 TYR A O   1 
ATOM   2892  C CB  . TYR A 1 373 ? 11.120  7.129   -9.092  1.00 33.54  ? 373 TYR A CB  1 
ATOM   2893  C CG  . TYR A 1 373 ? 10.541  7.261   -10.496 1.00 30.70  ? 373 TYR A CG  1 
ATOM   2894  C CD1 . TYR A 1 373 ? 10.643  6.246   -11.435 1.00 34.01  ? 373 TYR A CD1 1 
ATOM   2895  C CD2 . TYR A 1 373 ? 9.835   8.384   -10.873 1.00 34.01  ? 373 TYR A CD2 1 
ATOM   2896  C CE1 . TYR A 1 373 ? 10.097  6.346   -12.705 1.00 31.70  ? 373 TYR A CE1 1 
ATOM   2897  C CE2 . TYR A 1 373 ? 9.336   8.528   -12.160 1.00 33.00  ? 373 TYR A CE2 1 
ATOM   2898  C CZ  . TYR A 1 373 ? 9.470   7.509   -13.082 1.00 31.23  ? 373 TYR A CZ  1 
ATOM   2899  O OH  . TYR A 1 373 ? 8.914   7.666   -14.321 1.00 33.25  ? 373 TYR A OH  1 
ATOM   2900  N N   . LEU A 1 374 ? 10.739  4.201   -8.463  1.00 32.99  ? 374 LEU A N   1 
ATOM   2901  C CA  . LEU A 1 374 ? 10.465  2.865   -8.995  1.00 34.42  ? 374 LEU A CA  1 
ATOM   2902  C C   . LEU A 1 374 ? 9.311   2.197   -8.262  1.00 31.27  ? 374 LEU A C   1 
ATOM   2903  O O   . LEU A 1 374 ? 8.635   1.384   -8.836  1.00 34.99  ? 374 LEU A O   1 
ATOM   2904  C CB  . LEU A 1 374 ? 11.697  1.961   -8.939  1.00 31.05  ? 374 LEU A CB  1 
ATOM   2905  C CG  . LEU A 1 374 ? 12.852  2.413   -9.833  1.00 32.33  ? 374 LEU A CG  1 
ATOM   2906  C CD1 . LEU A 1 374 ? 14.180  1.768   -9.540  1.00 31.34  ? 374 LEU A CD1 1 
ATOM   2907  C CD2 . LEU A 1 374 ? 12.491  2.218   -11.265 1.00 32.63  ? 374 LEU A CD2 1 
ATOM   2908  N N   . GLU A 1 375 ? 9.143   2.452   -6.975  1.00 35.23  ? 375 GLU A N   1 
ATOM   2909  C CA  . GLU A 1 375 ? 8.173   1.720   -6.182  1.00 34.74  ? 375 GLU A CA  1 
ATOM   2910  C C   . GLU A 1 375 ? 6.768   2.241   -6.459  1.00 33.92  ? 375 GLU A C   1 
ATOM   2911  O O   . GLU A 1 375 ? 5.839   1.459   -6.456  1.00 35.62  ? 375 GLU A O   1 
ATOM   2912  C CB  . GLU A 1 375 ? 8.545   1.879   -4.710  1.00 34.44  ? 375 GLU A CB  1 
ATOM   2913  C CG  . GLU A 1 375 ? 7.535   1.324   -3.707  1.00 36.46  ? 375 GLU A CG  1 
ATOM   2914  C CD  . GLU A 1 375 ? 7.883   1.680   -2.251  1.00 43.85  ? 375 GLU A CD  1 
ATOM   2915  O OE1 . GLU A 1 375 ? 8.074   2.885   -1.832  1.00 39.64  ? 375 GLU A OE1 1 
ATOM   2916  O OE2 . GLU A 1 375 ? 7.937   0.684   -1.509  1.00 43.25  ? 375 GLU A OE2 1 
ATOM   2917  N N   . ASN A 1 376 ? 6.642   3.556   -6.677  1.00 31.15  ? 376 ASN A N   1 
ATOM   2918  C CA  . ASN A 1 376 ? 5.377   4.248   -6.649  1.00 33.74  ? 376 ASN A CA  1 
ATOM   2919  C C   . ASN A 1 376 ? 4.911   4.729   -8.033  1.00 31.64  ? 376 ASN A C   1 
ATOM   2920  O O   . ASN A 1 376 ? 3.753   5.105   -8.158  1.00 32.95  ? 376 ASN A O   1 
ATOM   2921  C CB  . ASN A 1 376 ? 5.454   5.416   -5.673  1.00 34.53  ? 376 ASN A CB  1 
ATOM   2922  C CG  . ASN A 1 376 ? 5.681   4.945   -4.260  1.00 35.70  ? 376 ASN A CG  1 
ATOM   2923  O OD1 . ASN A 1 376 ? 4.786   4.362   -3.650  1.00 33.66  ? 376 ASN A OD1 1 
ATOM   2924  N ND2 . ASN A 1 376 ? 6.873   5.155   -3.729  1.00 38.99  ? 376 ASN A ND2 1 
ATOM   2925  N N   . ILE A 1 377 ? 5.774   4.753   -9.057  1.00 25.39  ? 377 ILE A N   1 
ATOM   2926  C CA  . ILE A 1 377 ? 5.418   5.356   -10.334 1.00 27.61  ? 377 ILE A CA  1 
ATOM   2927  C C   . ILE A 1 377 ? 4.150   4.745   -10.925 1.00 28.89  ? 377 ILE A C   1 
ATOM   2928  O O   . ILE A 1 377 ? 3.351   5.464   -11.495 1.00 33.30  ? 377 ILE A O   1 
ATOM   2929  C CB  . ILE A 1 377 ? 6.572   5.312   -11.358 1.00 27.66  ? 377 ILE A CB  1 
ATOM   2930  C CG1 . ILE A 1 377 ? 6.223   6.036   -12.664 1.00 30.51  ? 377 ILE A CG1 1 
ATOM   2931  C CG2 . ILE A 1 377 ? 7.041   3.899   -11.644 1.00 25.77  ? 377 ILE A CG2 1 
ATOM   2932  C CD1 . ILE A 1 377 ? 5.859   7.505   -12.497 1.00 29.84  ? 377 ILE A CD1 1 
ATOM   2933  N N   . HIS A 1 378 ? 4.003   3.426   -10.850 1.00 29.22  ? 378 HIS A N   1 
ATOM   2934  C CA  . HIS A 1 378 ? 2.864   2.756   -11.433 1.00 29.25  ? 378 HIS A CA  1 
ATOM   2935  C C   . HIS A 1 378 ? 1.592   3.195   -10.714 1.00 33.12  ? 378 HIS A C   1 
ATOM   2936  O O   . HIS A 1 378 ? 0.501   3.154   -11.300 1.00 34.19  ? 378 HIS A O   1 
ATOM   2937  C CB  . HIS A 1 378 ? 3.051   1.228   -11.428 1.00 30.32  ? 378 HIS A CB  1 
ATOM   2938  C CG  . HIS A 1 378 ? 2.788   0.535   -10.128 1.00 32.93  ? 378 HIS A CG  1 
ATOM   2939  N ND1 . HIS A 1 378 ? 3.684   0.445   -9.076  1.00 38.97  ? 378 HIS A ND1 1 
ATOM   2940  C CD2 . HIS A 1 378 ? 1.703   -0.137  -9.727  1.00 36.82  ? 378 HIS A CD2 1 
ATOM   2941  C CE1 . HIS A 1 378 ? 3.155   -0.256  -8.097  1.00 37.28  ? 378 HIS A CE1 1 
ATOM   2942  N NE2 . HIS A 1 378 ? 1.940   -0.617  -8.464  1.00 35.32  ? 378 HIS A NE2 1 
ATOM   2943  N N   . ASN A 1 379 ? 1.719   3.547   -9.428  1.00 34.39  ? 379 ASN A N   1 
ATOM   2944  C CA  . ASN A 1 379 ? 0.577   4.044   -8.664  1.00 32.12  ? 379 ASN A CA  1 
ATOM   2945  C C   . ASN A 1 379 ? 0.241   5.471   -9.105  1.00 31.76  ? 379 ASN A C   1 
ATOM   2946  O O   . ASN A 1 379 ? -0.937  5.840   -9.209  1.00 31.05  ? 379 ASN A O   1 
ATOM   2947  C CB  . ASN A 1 379 ? 0.782   3.947   -7.156  1.00 29.86  ? 379 ASN A CB  1 
ATOM   2948  C CG  . ASN A 1 379 ? 0.696   2.534   -6.618  1.00 36.32  ? 379 ASN A CG  1 
ATOM   2949  O OD1 . ASN A 1 379 ? -0.022  1.684   -7.145  1.00 41.12  ? 379 ASN A OD1 1 
ATOM   2950  N ND2 . ASN A 1 379 ? 1.479   2.219   -5.597  1.00 43.58  ? 379 ASN A ND2 1 
ATOM   2951  N N   . ALA A 1 380 ? 1.263   6.267   -9.416  1.00 31.07  ? 380 ALA A N   1 
ATOM   2952  C CA  . ALA A 1 380 ? 0.992   7.638   -9.839  1.00 34.97  ? 380 ALA A CA  1 
ATOM   2953  C C   . ALA A 1 380 ? 0.365   7.647   -11.234 1.00 32.23  ? 380 ALA A C   1 
ATOM   2954  O O   . ALA A 1 380 ? -0.541  8.420   -11.482 1.00 32.75  ? 380 ALA A O   1 
ATOM   2955  C CB  . ALA A 1 380 ? 2.235   8.464   -9.780  1.00 32.05  ? 380 ALA A CB  1 
ATOM   2956  N N   . VAL A 1 381 ? 0.803   6.755   -12.126 1.00 30.18  ? 381 VAL A N   1 
ATOM   2957  C CA  . VAL A 1 381 ? 0.226   6.684   -13.460 1.00 33.30  ? 381 VAL A CA  1 
ATOM   2958  C C   . VAL A 1 381 ? -1.213  6.184   -13.364 1.00 31.09  ? 381 VAL A C   1 
ATOM   2959  O O   . VAL A 1 381 ? -2.127  6.720   -13.989 1.00 32.47  ? 381 VAL A O   1 
ATOM   2960  C CB  . VAL A 1 381 ? 1.083   5.810   -14.392 1.00 35.91  ? 381 VAL A CB  1 
ATOM   2961  C CG1 . VAL A 1 381 ? 0.378   5.448   -15.704 1.00 34.55  ? 381 VAL A CG1 1 
ATOM   2962  C CG2 . VAL A 1 381 ? 2.395   6.519   -14.665 1.00 37.47  ? 381 VAL A CG2 1 
ATOM   2963  N N   . ASN A 1 382 ? -1.400  5.173   -12.536 1.00 31.27  ? 382 ASN A N   1 
ATOM   2964  C CA  . ASN A 1 382 ? -2.700  4.564   -12.384 1.00 33.39  ? 382 ASN A CA  1 
ATOM   2965  C C   . ASN A 1 382 ? -3.699  5.588   -11.885 1.00 30.42  ? 382 ASN A C   1 
ATOM   2966  O O   . ASN A 1 382 ? -4.825  5.593   -12.346 1.00 33.92  ? 382 ASN A O   1 
ATOM   2967  C CB  . ASN A 1 382 ? -2.656  3.354   -11.463 1.00 33.20  ? 382 ASN A CB  1 
ATOM   2968  C CG  . ASN A 1 382 ? -4.046  2.802   -11.267 1.00 32.79  ? 382 ASN A CG  1 
ATOM   2969  O OD1 . ASN A 1 382 ? -4.644  2.298   -12.202 1.00 36.06  ? 382 ASN A OD1 1 
ATOM   2970  N ND2 . ASN A 1 382 ? -4.606  2.892   -10.077 1.00 35.65  ? 382 ASN A ND2 1 
ATOM   2971  N N   . GLN A 1 383 ? -3.281  6.398   -10.913 1.00 33.22  ? 383 GLN A N   1 
ATOM   2972  C CA  . GLN A 1 383 ? -4.094  7.477   -10.368 1.00 31.34  ? 383 GLN A CA  1 
ATOM   2973  C C   . GLN A 1 383 ? -4.391  8.510   -11.447 1.00 30.47  ? 383 GLN A C   1 
ATOM   2974  O O   . GLN A 1 383 ? -5.513  8.924   -11.587 1.00 34.16  ? 383 GLN A O   1 
ATOM   2975  C CB  . GLN A 1 383 ? -3.388  8.115   -9.174  1.00 32.76  ? 383 GLN A CB  1 
ATOM   2976  C CG  . GLN A 1 383 ? -4.179  9.210   -8.469  1.00 32.95  ? 383 GLN A CG  1 
ATOM   2977  C CD  . GLN A 1 383 ? -5.491  8.715   -7.922  1.00 37.29  ? 383 GLN A CD  1 
ATOM   2978  O OE1 . GLN A 1 383 ? -5.531  8.065   -6.875  1.00 40.53  ? 383 GLN A OE1 1 
ATOM   2979  N NE2 . GLN A 1 383 ? -6.553  8.940   -8.688  1.00 35.42  ? 383 GLN A NE2 1 
ATOM   2980  N N   . LEU A 1 384 ? -3.436  8.856   -12.307 1.00 31.58  ? 384 LEU A N   1 
ATOM   2981  C CA  . LEU A 1 384 ? -3.734  9.821   -13.357 1.00 29.72  ? 384 LEU A CA  1 
ATOM   2982  C C   . LEU A 1 384 ? -4.822  9.280   -14.287 1.00 35.34  ? 384 LEU A C   1 
ATOM   2983  O O   . LEU A 1 384 ? -5.681  10.031  -14.749 1.00 35.76  ? 384 LEU A O   1 
ATOM   2984  C CB  . LEU A 1 384 ? -2.461  10.128  -14.134 1.00 28.40  ? 384 LEU A CB  1 
ATOM   2985  C CG  . LEU A 1 384 ? -2.608  11.098  -15.301 1.00 28.43  ? 384 LEU A CG  1 
ATOM   2986  C CD1 . LEU A 1 384 ? -2.980  12.480  -14.835 1.00 31.43  ? 384 LEU A CD1 1 
ATOM   2987  C CD2 . LEU A 1 384 ? -1.317  11.160  -16.062 1.00 30.86  ? 384 LEU A CD2 1 
ATOM   2988  N N   . ILE A 1 385 ? -4.761  7.977   -14.597 1.00 37.34  ? 385 ILE A N   1 
ATOM   2989  C CA  . ILE A 1 385 ? -5.739  7.347   -15.471 1.00 34.61  ? 385 ILE A CA  1 
ATOM   2990  C C   . ILE A 1 385 ? -7.101  7.290   -14.778 1.00 33.69  ? 385 ILE A C   1 
ATOM   2991  O O   . ILE A 1 385 ? -8.123  7.589   -15.376 1.00 41.37  ? 385 ILE A O   1 
ATOM   2992  C CB  . ILE A 1 385 ? -5.222  5.979   -15.925 1.00 38.59  ? 385 ILE A CB  1 
ATOM   2993  C CG1 . ILE A 1 385 ? -4.117  6.179   -16.933 1.00 40.52  ? 385 ILE A CG1 1 
ATOM   2994  C CG2 . ILE A 1 385 ? -6.325  5.092   -16.496 1.00 38.69  ? 385 ILE A CG2 1 
ATOM   2995  C CD1 . ILE A 1 385 ? -3.131  5.037   -16.990 1.00 41.52  ? 385 ILE A CD1 1 
ATOM   2996  N N   . GLU A 1 386 ? -7.121  6.991   -13.495 1.00 36.90  ? 386 GLU A N   1 
ATOM   2997  C CA  . GLU A 1 386 ? -8.366  6.968   -12.751 1.00 38.73  ? 386 GLU A CA  1 
ATOM   2998  C C   . GLU A 1 386 ? -9.093  8.300   -12.932 1.00 41.17  ? 386 GLU A C   1 
ATOM   2999  O O   . GLU A 1 386 ? -10.311 8.347   -13.110 1.00 44.05  ? 386 GLU A O   1 
ATOM   3000  C CB  . GLU A 1 386 ? -8.001  6.654   -11.308 1.00 43.70  ? 386 GLU A CB  1 
ATOM   3001  C CG  . GLU A 1 386 ? -9.037  5.843   -10.546 1.00 59.20  ? 386 GLU A CG  1 
ATOM   3002  C CD  . GLU A 1 386 ? -8.864  4.355   -10.749 1.00 62.64  ? 386 GLU A CD  1 
ATOM   3003  O OE1 . GLU A 1 386 ? -7.733  3.856   -10.622 1.00 72.39  ? 386 GLU A OE1 1 
ATOM   3004  O OE2 . GLU A 1 386 ? -9.880  3.698   -11.009 1.00 72.78  ? 386 GLU A OE2 1 
ATOM   3005  N N   . PHE A 1 387 ? -8.343  9.404   -12.961 1.00 39.72  ? 387 PHE A N   1 
ATOM   3006  C CA  . PHE A 1 387 ? -8.961  10.718  -13.100 1.00 32.99  ? 387 PHE A CA  1 
ATOM   3007  C C   . PHE A 1 387 ? -9.641  10.890  -14.454 1.00 32.11  ? 387 PHE A C   1 
ATOM   3008  O O   . PHE A 1 387 ? -10.517 11.726  -14.577 1.00 35.17  ? 387 PHE A O   1 
ATOM   3009  C CB  . PHE A 1 387 ? -7.940  11.853  -12.986 1.00 32.25  ? 387 PHE A CB  1 
ATOM   3010  C CG  . PHE A 1 387 ? -7.357  12.101  -11.603 1.00 28.56  ? 387 PHE A CG  1 
ATOM   3011  C CD1 . PHE A 1 387 ? -8.119  11.925  -10.458 1.00 29.54  ? 387 PHE A CD1 1 
ATOM   3012  C CD2 . PHE A 1 387 ? -6.027  12.444  -11.451 1.00 26.02  ? 387 PHE A CD2 1 
ATOM   3013  C CE1 . PHE A 1 387 ? -7.568  12.134  -9.205  1.00 28.86  ? 387 PHE A CE1 1 
ATOM   3014  C CE2 . PHE A 1 387 ? -5.493  12.651  -10.202 1.00 27.98  ? 387 PHE A CE2 1 
ATOM   3015  C CZ  . PHE A 1 387 ? -6.257  12.490  -9.082  1.00 26.59  ? 387 PHE A CZ  1 
ATOM   3016  N N   . CYS A 1 388 ? -9.222  10.155  -15.483 1.00 34.95  ? 388 CYS A N   1 
ATOM   3017  C CA  . CYS A 1 388 ? -9.772  10.394  -16.806 1.00 38.94  ? 388 CYS A CA  1 
ATOM   3018  C C   . CYS A 1 388 ? -11.196 9.860   -16.934 1.00 42.41  ? 388 CYS A C   1 
ATOM   3019  O O   . CYS A 1 388 ? -12.001 10.415  -17.663 1.00 45.14  ? 388 CYS A O   1 
ATOM   3020  C CB  . CYS A 1 388 ? -8.964  9.750   -17.916 1.00 35.78  ? 388 CYS A CB  1 
ATOM   3021  S SG  . CYS A 1 388 ? -7.250  10.311  -17.986 1.00 43.40  ? 388 CYS A SG  1 
ATOM   3022  N N   . GLY A 1 389 ? -11.483 8.735   -16.288 1.00 51.38  ? 389 GLY A N   1 
ATOM   3023  C CA  . GLY A 1 389 ? -12.734 8.040   -16.541 1.00 45.25  ? 389 GLY A CA  1 
ATOM   3024  C C   . GLY A 1 389 ? -12.717 7.452   -17.944 1.00 47.66  ? 389 GLY A C   1 
ATOM   3025  O O   . GLY A 1 389 ? -11.660 7.313   -18.548 1.00 45.55  ? 389 GLY A O   1 
ATOM   3026  N N   . ARG A 1 390 ? -13.917 7.202   -18.465 1.00 58.25  ? 390 ARG A N   1 
ATOM   3027  C CA  . ARG A 1 390 ? -14.140 6.585   -19.766 1.00 62.11  ? 390 ARG A CA  1 
ATOM   3028  C C   . ARG A 1 390 ? -13.479 7.369   -20.895 1.00 55.76  ? 390 ARG A C   1 
ATOM   3029  O O   . ARG A 1 390 ? -13.070 6.784   -21.892 1.00 51.47  ? 390 ARG A O   1 
ATOM   3030  C CB  . ARG A 1 390 ? -15.646 6.419   -20.012 1.00 76.34  ? 390 ARG A CB  1 
ATOM   3031  C CG  . ARG A 1 390 ? -16.552 7.565   -19.564 1.00 98.29  ? 390 ARG A CG  1 
ATOM   3032  C CD  . ARG A 1 390 ? -18.063 7.240   -19.483 1.00 102.92 ? 390 ARG A CD  1 
ATOM   3033  N NE  . ARG A 1 390 ? -18.575 6.740   -18.194 1.00 96.78  ? 390 ARG A NE  1 
ATOM   3034  C CZ  . ARG A 1 390 ? -18.668 5.470   -17.755 1.00 84.12  ? 390 ARG A CZ  1 
ATOM   3035  N NH1 . ARG A 1 390 ? -19.369 5.221   -16.659 1.00 79.79  ? 390 ARG A NH1 1 
ATOM   3036  N NH2 . ARG A 1 390 ? -18.141 4.445   -18.419 1.00 78.37  ? 390 ARG A NH2 1 
ATOM   3037  N N   . GLY A 1 391 ? -13.341 8.687   -20.740 1.00 58.70  ? 391 GLY A N   1 
ATOM   3038  C CA  . GLY A 1 391 ? -12.782 9.503   -21.809 1.00 55.41  ? 391 GLY A CA  1 
ATOM   3039  C C   . GLY A 1 391 ? -11.548 8.858   -22.440 1.00 59.85  ? 391 GLY A C   1 
ATOM   3040  O O   . GLY A 1 391 ? -11.148 9.214   -23.548 1.00 62.03  ? 391 GLY A O   1 
ATOM   3041  N N   . VAL A 1 392 ? -10.939 7.911   -21.717 1.00 60.14  ? 392 VAL A N   1 
ATOM   3042  C CA  . VAL A 1 392 ? -9.737  7.227   -22.173 1.00 65.66  ? 392 VAL A CA  1 
ATOM   3043  C C   . VAL A 1 392 ? -10.111 5.997   -23.005 1.00 62.73  ? 392 VAL A C   1 
ATOM   3044  O O   . VAL A 1 392 ? -9.353  5.606   -23.876 1.00 73.90  ? 392 VAL A O   1 
ATOM   3045  C CB  . VAL A 1 392 ? -8.855  6.894   -20.942 1.00 67.18  ? 392 VAL A CB  1 
ATOM   3046  C CG1 . VAL A 1 392 ? -8.502  5.413   -20.813 1.00 72.83  ? 392 VAL A CG1 1 
ATOM   3047  C CG2 . VAL A 1 392 ? -7.597  7.741   -20.903 1.00 55.74  ? 392 VAL A CG2 1 
ATOM   3048  N N   . VAL A 1 393 ? -11.264 5.378   -22.725 1.00 80.24  ? 393 VAL A N   1 
ATOM   3049  C CA  . VAL A 1 393 ? -11.723 4.207   -23.468 1.00 84.57  ? 393 VAL A CA  1 
ATOM   3050  C C   . VAL A 1 393 ? -12.071 4.655   -24.886 1.00 84.83  ? 393 VAL A C   1 
ATOM   3051  O O   . VAL A 1 393 ? -11.644 4.035   -25.859 1.00 76.95  ? 393 VAL A O   1 
ATOM   3052  C CB  . VAL A 1 393 ? -12.942 3.461   -22.882 1.00 81.78  ? 393 VAL A CB  1 
ATOM   3053  C CG1 . VAL A 1 393 ? -13.160 2.116   -23.569 1.00 82.73  ? 393 VAL A CG1 1 
ATOM   3054  C CG2 . VAL A 1 393 ? -12.864 3.254   -21.375 1.00 87.79  ? 393 VAL A CG2 1 
ATOM   3055  N N   . MET A 1 394 ? -12.901 5.700   -24.977 1.00 74.68  ? 394 MET A N   1 
ATOM   3056  C CA  . MET A 1 394 ? -13.293 6.224   -26.263 1.00 69.89  ? 394 MET A CA  1 
ATOM   3057  C C   . MET A 1 394 ? -13.164 7.739   -26.231 1.00 61.14  ? 394 MET A C   1 
ATOM   3058  O O   . MET A 1 394 ? -13.860 8.413   -25.486 1.00 67.64  ? 394 MET A O   1 
ATOM   3059  C CB  . MET A 1 394 ? -14.718 5.800   -26.631 1.00 79.64  ? 394 MET A CB  1 
ATOM   3060  C CG  . MET A 1 394 ? -15.034 5.958   -28.132 1.00 78.00  ? 394 MET A CG  1 
ATOM   3061  S SD  . MET A 1 394 ? -15.272 7.639   -28.752 1.00 78.97  ? 394 MET A SD  1 
ATOM   3062  C CE  . MET A 1 394 ? -15.239 7.465   -30.543 1.00 62.91  ? 394 MET A CE  1 
ATOM   3063  N N   . SER A 1 395 ? -12.225 8.215   -27.043 1.00 59.03  ? 395 SER A N   1 
ATOM   3064  C CA  . SER A 1 395 ? -11.944 9.610   -27.291 1.00 50.51  ? 395 SER A CA  1 
ATOM   3065  C C   . SER A 1 395 ? -11.832 9.790   -28.793 1.00 41.36  ? 395 SER A C   1 
ATOM   3066  O O   . SER A 1 395 ? -11.047 9.116   -29.439 1.00 42.73  ? 395 SER A O   1 
ATOM   3067  C CB  . SER A 1 395 ? -10.678 10.017  -26.636 1.00 55.13  ? 395 SER A CB  1 
ATOM   3068  O OG  . SER A 1 395 ? -10.971 10.641  -25.401 1.00 65.36  ? 395 SER A OG  1 
ATOM   3069  N N   . PRO A 1 396 ? -12.623 10.677  -29.410 1.00 42.81  ? 396 PRO A N   1 
ATOM   3070  C CA  . PRO A 1 396 ? -12.677 10.753  -30.876 1.00 40.69  ? 396 PRO A CA  1 
ATOM   3071  C C   . PRO A 1 396 ? -11.341 11.079  -31.528 1.00 39.38  ? 396 PRO A C   1 
ATOM   3072  O O   . PRO A 1 396 ? -10.510 11.764  -30.938 1.00 35.42  ? 396 PRO A O   1 
ATOM   3073  C CB  . PRO A 1 396 ? -13.675 11.852  -31.103 1.00 42.50  ? 396 PRO A CB  1 
ATOM   3074  C CG  . PRO A 1 396 ? -14.510 11.848  -29.850 1.00 46.99  ? 396 PRO A CG  1 
ATOM   3075  C CD  . PRO A 1 396 ? -13.520 11.619  -28.739 1.00 41.03  ? 396 PRO A CD  1 
ATOM   3076  N N   . THR A 1 397 ? -11.142 10.562  -32.743 1.00 39.08  ? 397 THR A N   1 
ATOM   3077  C CA  . THR A 1 397 ? -10.015 10.973  -33.570 1.00 36.24  ? 397 THR A CA  1 
ATOM   3078  C C   . THR A 1 397 ? -10.293 12.349  -34.149 1.00 36.23  ? 397 THR A C   1 
ATOM   3079  O O   . THR A 1 397 ? -11.375 12.901  -34.003 1.00 41.16  ? 397 THR A O   1 
ATOM   3080  C CB  . THR A 1 397 ? -9.773  9.983   -34.696 1.00 32.28  ? 397 THR A CB  1 
ATOM   3081  O OG1 . THR A 1 397 ? -10.964 9.926   -35.477 1.00 35.69  ? 397 THR A OG1 1 
ATOM   3082  C CG2 . THR A 1 397 ? -9.498  8.595   -34.162 1.00 31.72  ? 397 THR A CG2 1 
ATOM   3083  N N   . LYS A 1 398 ? -9.292  12.888  -34.822 1.00 39.54  ? 398 LYS A N   1 
ATOM   3084  C CA  . LYS A 1 398 ? -9.449  14.159  -35.493 1.00 40.93  ? 398 LYS A CA  1 
ATOM   3085  C C   . LYS A 1 398 ? -10.455 13.989  -36.628 1.00 35.41  ? 398 LYS A C   1 
ATOM   3086  O O   . LYS A 1 398 ? -11.281 14.863  -36.835 1.00 41.04  ? 398 LYS A O   1 
ATOM   3087  C CB  . LYS A 1 398 ? -8.111  14.717  -35.988 1.00 39.97  ? 398 LYS A CB  1 
ATOM   3088  C CG  . LYS A 1 398 ? -8.288  16.099  -36.544 1.00 41.52  ? 398 LYS A CG  1 
ATOM   3089  C CD  . LYS A 1 398 ? -7.042  16.961  -36.611 1.00 51.70  ? 398 LYS A CD  1 
ATOM   3090  C CE  . LYS A 1 398 ? -7.363  18.306  -37.181 1.00 52.33  ? 398 LYS A CE  1 
ATOM   3091  N NZ  . LYS A 1 398 ? -7.800  18.167  -38.580 1.00 54.44  ? 398 LYS A NZ  1 
ATOM   3092  N N   . ALA A 1 399 ? -10.374 12.869  -37.355 1.00 32.83  ? 399 ALA A N   1 
ATOM   3093  C CA  . ALA A 1 399 ? -11.303 12.603  -38.439 1.00 34.15  ? 399 ALA A CA  1 
ATOM   3094  C C   . ALA A 1 399 ? -12.755 12.600  -37.926 1.00 38.12  ? 399 ALA A C   1 
ATOM   3095  O O   . ALA A 1 399 ? -13.619 13.173  -38.569 1.00 43.15  ? 399 ALA A O   1 
ATOM   3096  C CB  . ALA A 1 399 ? -10.903 11.317  -39.138 1.00 34.90  ? 399 ALA A CB  1 
ATOM   3097  N N   . ASP A 1 400 ? -13.008 12.083  -36.709 1.00 38.61  ? 400 ASP A N   1 
ATOM   3098  C CA  . ASP A 1 400 ? -14.345 12.074  -36.124 1.00 36.42  ? 400 ASP A CA  1 
ATOM   3099  C C   . ASP A 1 400 ? -14.815 13.509  -35.874 1.00 36.48  ? 400 ASP A C   1 
ATOM   3100  O O   . ASP A 1 400 ? -15.945 13.853  -36.179 1.00 41.78  ? 400 ASP A O   1 
ATOM   3101  C CB  . ASP A 1 400 ? -14.425 11.304  -34.815 1.00 32.41  ? 400 ASP A CB  1 
ATOM   3102  C CG  . ASP A 1 400 ? -14.177 9.799   -34.862 1.00 36.08  ? 400 ASP A CG  1 
ATOM   3103  O OD1 . ASP A 1 400 ? -14.892 9.107   -35.602 1.00 35.43  ? 400 ASP A OD1 1 
ATOM   3104  O OD2 . ASP A 1 400 ? -13.266 9.315   -34.137 1.00 39.07  ? 400 ASP A OD2 1 
ATOM   3105  N N   . PHE A 1 401 ? -13.960 14.363  -35.326 1.00 37.51  ? 401 PHE A N   1 
ATOM   3106  C CA  . PHE A 1 401 ? -14.360 15.741  -35.095 1.00 39.45  ? 401 PHE A CA  1 
ATOM   3107  C C   . PHE A 1 401 ? -14.495 16.496  -36.420 1.00 40.02  ? 401 PHE A C   1 
ATOM   3108  O O   . PHE A 1 401 ? -15.233 17.452  -36.494 1.00 42.55  ? 401 PHE A O   1 
ATOM   3109  C CB  . PHE A 1 401 ? -13.348 16.470  -34.215 1.00 36.55  ? 401 PHE A CB  1 
ATOM   3110  C CG  . PHE A 1 401 ? -13.432 16.257  -32.715 1.00 35.62  ? 401 PHE A CG  1 
ATOM   3111  C CD1 . PHE A 1 401 ? -14.614 16.454  -32.024 1.00 35.99  ? 401 PHE A CD1 1 
ATOM   3112  C CD2 . PHE A 1 401 ? -12.305 15.881  -31.994 1.00 37.53  ? 401 PHE A CD2 1 
ATOM   3113  C CE1 . PHE A 1 401 ? -14.676 16.271  -30.650 1.00 37.90  ? 401 PHE A CE1 1 
ATOM   3114  C CE2 . PHE A 1 401 ? -12.369 15.700  -30.631 1.00 38.82  ? 401 PHE A CE2 1 
ATOM   3115  C CZ  . PHE A 1 401 ? -13.552 15.908  -29.955 1.00 38.73  ? 401 PHE A CZ  1 
ATOM   3116  N N   . ASP A 1 402 ? -13.796 16.087  -37.476 1.00 43.50  ? 402 ASP A N   1 
ATOM   3117  C CA  . ASP A 1 402 ? -13.882 16.815  -38.739 1.00 47.29  ? 402 ASP A CA  1 
ATOM   3118  C C   . ASP A 1 402 ? -15.071 16.354  -39.594 1.00 41.85  ? 402 ASP A C   1 
ATOM   3119  O O   . ASP A 1 402 ? -15.304 16.878  -40.670 1.00 41.47  ? 402 ASP A O   1 
ATOM   3120  C CB  . ASP A 1 402 ? -12.583 16.711  -39.533 1.00 44.95  ? 402 ASP A CB  1 
ATOM   3121  C CG  . ASP A 1 402 ? -11.352 17.400  -38.948 1.00 43.04  ? 402 ASP A CG  1 
ATOM   3122  O OD1 . ASP A 1 402 ? -11.500 18.212  -38.016 1.00 47.02  ? 402 ASP A OD1 1 
ATOM   3123  O OD2 . ASP A 1 402 ? -10.239 17.104  -39.421 1.00 44.59  ? 402 ASP A OD2 1 
ATOM   3124  N N   . HIS A 1 403 ? -15.825 15.348  -39.172 1.00 42.44  ? 403 HIS A N   1 
ATOM   3125  C CA  . HIS A 1 403 ? -16.959 14.925  -39.979 1.00 44.62  ? 403 HIS A CA  1 
ATOM   3126  C C   . HIS A 1 403 ? -17.932 16.088  -40.119 1.00 42.62  ? 403 HIS A C   1 
ATOM   3127  O O   . HIS A 1 403 ? -18.233 16.748  -39.137 1.00 46.77  ? 403 HIS A O   1 
ATOM   3128  C CB  . HIS A 1 403 ? -17.675 13.746  -39.331 1.00 41.61  ? 403 HIS A CB  1 
ATOM   3129  C CG  . HIS A 1 403 ? -18.657 13.010  -40.170 1.00 41.29  ? 403 HIS A CG  1 
ATOM   3130  N ND1 . HIS A 1 403 ? -19.966 13.403  -40.329 1.00 44.60  ? 403 HIS A ND1 1 
ATOM   3131  C CD2 . HIS A 1 403 ? -18.538 11.843  -40.798 1.00 43.72  ? 403 HIS A CD2 1 
ATOM   3132  C CE1 . HIS A 1 403 ? -20.590 12.509  -41.070 1.00 43.39  ? 403 HIS A CE1 1 
ATOM   3133  N NE2 . HIS A 1 403 ? -19.741 11.557  -41.378 1.00 46.43  ? 403 HIS A NE2 1 
ATOM   3134  N N   . PRO A 1 404 ? -18.467 16.362  -41.325 1.00 48.38  ? 404 PRO A N   1 
ATOM   3135  C CA  . PRO A 1 404 ? -19.271 17.559  -41.569 1.00 45.51  ? 404 PRO A CA  1 
ATOM   3136  C C   . PRO A 1 404 ? -20.540 17.614  -40.715 1.00 43.80  ? 404 PRO A C   1 
ATOM   3137  O O   . PRO A 1 404 ? -20.959 18.691  -40.305 1.00 45.61  ? 404 PRO A O   1 
ATOM   3138  C CB  . PRO A 1 404 ? -19.643 17.482  -43.058 1.00 49.45  ? 404 PRO A CB  1 
ATOM   3139  C CG  . PRO A 1 404 ? -18.816 16.362  -43.638 1.00 51.69  ? 404 PRO A CG  1 
ATOM   3140  C CD  . PRO A 1 404 ? -18.431 15.468  -42.491 1.00 56.08  ? 404 PRO A CD  1 
ATOM   3141  N N   . PHE A 1 405 ? -21.150 16.460  -40.430 1.00 39.12  ? 405 PHE A N   1 
ATOM   3142  C CA  . PHE A 1 405 ? -22.395 16.465  -39.690 1.00 40.30  ? 405 PHE A CA  1 
ATOM   3143  C C   . PHE A 1 405 ? -22.179 16.070  -38.230 1.00 41.05  ? 405 PHE A C   1 
ATOM   3144  O O   . PHE A 1 405 ? -22.655 16.754  -37.342 1.00 42.20  ? 405 PHE A O   1 
ATOM   3145  C CB  . PHE A 1 405 ? -23.409 15.533  -40.350 1.00 45.18  ? 405 PHE A CB  1 
ATOM   3146  C CG  . PHE A 1 405 ? -24.741 15.475  -39.620 1.00 49.22  ? 405 PHE A CG  1 
ATOM   3147  C CD1 . PHE A 1 405 ? -25.647 16.531  -39.714 1.00 52.96  ? 405 PHE A CD1 1 
ATOM   3148  C CD2 . PHE A 1 405 ? -25.086 14.356  -38.862 1.00 50.81  ? 405 PHE A CD2 1 
ATOM   3149  C CE1 . PHE A 1 405 ? -26.862 16.482  -39.046 1.00 52.34  ? 405 PHE A CE1 1 
ATOM   3150  C CE2 . PHE A 1 405 ? -26.306 14.298  -38.209 1.00 50.56  ? 405 PHE A CE2 1 
ATOM   3151  C CZ  . PHE A 1 405 ? -27.183 15.373  -38.286 1.00 53.62  ? 405 PHE A CZ  1 
ATOM   3152  N N   . LEU A 1 406 ? -21.520 14.938  -37.970 1.00 41.76  ? 406 LEU A N   1 
ATOM   3153  C CA  . LEU A 1 406 ? -21.449 14.420  -36.611 1.00 37.06  ? 406 LEU A CA  1 
ATOM   3154  C C   . LEU A 1 406 ? -20.358 15.142  -35.831 1.00 37.41  ? 406 LEU A C   1 
ATOM   3155  O O   . LEU A 1 406 ? -20.413 15.199  -34.611 1.00 41.89  ? 406 LEU A O   1 
ATOM   3156  C CB  . LEU A 1 406 ? -21.205 12.918  -36.602 1.00 34.13  ? 406 LEU A CB  1 
ATOM   3157  C CG  . LEU A 1 406 ? -22.321 12.080  -37.211 1.00 36.99  ? 406 LEU A CG  1 
ATOM   3158  C CD1 . LEU A 1 406 ? -21.840 10.668  -37.529 1.00 37.38  ? 406 LEU A CD1 1 
ATOM   3159  C CD2 . LEU A 1 406 ? -23.541 12.075  -36.294 1.00 39.46  ? 406 LEU A CD2 1 
ATOM   3160  N N   . GLY A 1 407 ? -19.376 15.694  -36.541 1.00 34.00  ? 407 GLY A N   1 
ATOM   3161  C CA  . GLY A 1 407 ? -18.225 16.270  -35.883 1.00 33.50  ? 407 GLY A CA  1 
ATOM   3162  C C   . GLY A 1 407 ? -18.634 17.449  -35.025 1.00 35.92  ? 407 GLY A C   1 
ATOM   3163  O O   . GLY A 1 407 ? -18.235 17.546  -33.872 1.00 42.98  ? 407 GLY A O   1 
ATOM   3164  N N   . PRO A 1 408 ? -19.378 18.422  -35.572 1.00 36.28  ? 408 PRO A N   1 
ATOM   3165  C CA  . PRO A 1 408 ? -19.875 19.521  -34.754 1.00 41.02  ? 408 PRO A CA  1 
ATOM   3166  C C   . PRO A 1 408 ? -20.729 19.002  -33.609 1.00 38.41  ? 408 PRO A C   1 
ATOM   3167  O O   . PRO A 1 408 ? -20.766 19.627  -32.559 1.00 40.84  ? 408 PRO A O   1 
ATOM   3168  C CB  . PRO A 1 408 ? -20.659 20.404  -35.746 1.00 39.57  ? 408 PRO A CB  1 
ATOM   3169  C CG  . PRO A 1 408 ? -19.986 20.143  -37.060 1.00 36.47  ? 408 PRO A CG  1 
ATOM   3170  C CD  . PRO A 1 408 ? -19.603 18.645  -37.005 1.00 38.89  ? 408 PRO A CD  1 
ATOM   3171  N N   . LYS A 1 409 ? -21.343 17.829  -33.787 1.00 39.46  ? 409 LYS A N   1 
ATOM   3172  C CA  . LYS A 1 409 ? -22.177 17.256  -32.743 1.00 43.43  ? 409 LYS A CA  1 
ATOM   3173  C C   . LYS A 1 409 ? -21.314 16.751  -31.591 1.00 43.48  ? 409 LYS A C   1 
ATOM   3174  O O   . LYS A 1 409 ? -21.734 16.835  -30.439 1.00 40.85  ? 409 LYS A O   1 
ATOM   3175  C CB  . LYS A 1 409 ? -23.125 16.189  -33.299 1.00 48.60  ? 409 LYS A CB  1 
ATOM   3176  C CG  . LYS A 1 409 ? -24.166 16.710  -34.284 1.00 53.45  ? 409 LYS A CG  1 
ATOM   3177  C CD  . LYS A 1 409 ? -25.523 17.031  -33.671 1.00 68.17  ? 409 LYS A CD  1 
ATOM   3178  C CE  . LYS A 1 409 ? -26.457 17.885  -34.506 1.00 68.69  ? 409 LYS A CE  1 
ATOM   3179  N NZ  . LYS A 1 409 ? -26.224 17.664  -35.931 1.00 70.20  ? 409 LYS A NZ  1 
ATOM   3180  N N   . LEU A 1 410 ? -20.123 16.221  -31.915 1.00 44.83  ? 410 LEU A N   1 
ATOM   3181  C CA  . LEU A 1 410 ? -19.152 15.784  -30.913 1.00 43.53  ? 410 LEU A CA  1 
ATOM   3182  C C   . LEU A 1 410 ? -18.579 16.966  -30.155 1.00 38.61  ? 410 LEU A C   1 
ATOM   3183  O O   . LEU A 1 410 ? -18.425 16.924  -28.940 1.00 42.17  ? 410 LEU A O   1 
ATOM   3184  C CB  . LEU A 1 410 ? -18.024 14.977  -31.538 1.00 40.51  ? 410 LEU A CB  1 
ATOM   3185  C CG  . LEU A 1 410 ? -18.378 13.518  -31.795 1.00 41.44  ? 410 LEU A CG  1 
ATOM   3186  C CD1 . LEU A 1 410 ? -17.422 12.954  -32.800 1.00 43.98  ? 410 LEU A CD1 1 
ATOM   3187  C CD2 . LEU A 1 410 ? -18.361 12.719  -30.503 1.00 41.25  ? 410 LEU A CD2 1 
ATOM   3188  N N   . GLU A 1 411 ? -18.265 18.024  -30.884 1.00 41.39  ? 411 GLU A N   1 
ATOM   3189  C CA  . GLU A 1 411 ? -17.693 19.198  -30.265 1.00 39.90  ? 411 GLU A CA  1 
ATOM   3190  C C   . GLU A 1 411 ? -18.683 19.719  -29.247 1.00 42.22  ? 411 GLU A C   1 
ATOM   3191  O O   . GLU A 1 411 ? -18.287 20.324  -28.257 1.00 49.74  ? 411 GLU A O   1 
ATOM   3192  C CB  . GLU A 1 411 ? -17.397 20.286  -31.297 1.00 46.98  ? 411 GLU A CB  1 
ATOM   3193  C CG  . GLU A 1 411 ? -16.320 19.869  -32.290 1.00 47.11  ? 411 GLU A CG  1 
ATOM   3194  C CD  . GLU A 1 411 ? -15.872 20.978  -33.219 1.00 50.82  ? 411 GLU A CD  1 
ATOM   3195  O OE1 . GLU A 1 411 ? -16.731 21.552  -33.894 1.00 63.46  ? 411 GLU A OE1 1 
ATOM   3196  O OE2 . GLU A 1 411 ? -14.670 21.233  -33.308 1.00 60.30  ? 411 GLU A OE2 1 
ATOM   3197  N N   . GLU A 1 412 ? -19.965 19.510  -29.540 1.00 40.17  ? 412 GLU A N   1 
ATOM   3198  C CA  . GLU A 1 412 ? -21.049 19.936  -28.666 1.00 41.35  ? 412 GLU A CA  1 
ATOM   3199  C C   . GLU A 1 412 ? -21.153 18.975  -27.495 1.00 38.38  ? 412 GLU A C   1 
ATOM   3200  O O   . GLU A 1 412 ? -21.169 19.377  -26.346 1.00 42.92  ? 412 GLU A O   1 
ATOM   3201  C CB  . GLU A 1 412 ? -22.365 19.918  -29.453 1.00 44.55  ? 412 GLU A CB  1 
ATOM   3202  C CG  . GLU A 1 412 ? -23.521 20.606  -28.746 1.00 48.70  ? 412 GLU A CG  1 
ATOM   3203  C CD  . GLU A 1 412 ? -24.914 20.388  -29.307 1.00 55.90  ? 412 GLU A CD  1 
ATOM   3204  O OE1 . GLU A 1 412 ? -25.140 19.736  -30.370 1.00 47.79  ? 412 GLU A OE1 1 
ATOM   3205  O OE2 . GLU A 1 412 ? -25.800 20.910  -28.588 1.00 59.59  ? 412 GLU A OE2 1 
ATOM   3206  N N   . ALA A 1 413 ? -21.225 17.686  -27.799 1.00 37.88  ? 413 ALA A N   1 
ATOM   3207  C CA  . ALA A 1 413 ? -21.432 16.693  -26.768 1.00 36.19  ? 413 ALA A CA  1 
ATOM   3208  C C   . ALA A 1 413 ? -20.272 16.585  -25.775 1.00 38.91  ? 413 ALA A C   1 
ATOM   3209  O O   . ALA A 1 413 ? -20.526 16.277  -24.623 1.00 40.99  ? 413 ALA A O   1 
ATOM   3210  C CB  . ALA A 1 413 ? -21.652 15.380  -27.435 1.00 39.07  ? 413 ALA A CB  1 
ATOM   3211  N N   . LEU A 1 414 ? -19.009 16.725  -26.216 1.00 36.78  ? 414 LEU A N   1 
ATOM   3212  C CA  . LEU A 1 414 ? -17.871 16.396  -25.372 1.00 35.64  ? 414 LEU A CA  1 
ATOM   3213  C C   . LEU A 1 414 ? -17.181 17.626  -24.805 1.00 38.31  ? 414 LEU A C   1 
ATOM   3214  O O   . LEU A 1 414 ? -16.124 17.463  -24.206 1.00 43.02  ? 414 LEU A O   1 
ATOM   3215  C CB  . LEU A 1 414 ? -16.862 15.578  -26.169 1.00 36.95  ? 414 LEU A CB  1 
ATOM   3216  C CG  . LEU A 1 414 ? -17.397 14.265  -26.721 1.00 40.30  ? 414 LEU A CG  1 
ATOM   3217  C CD1 . LEU A 1 414 ? -16.304 13.380  -27.269 1.00 39.34  ? 414 LEU A CD1 1 
ATOM   3218  C CD2 . LEU A 1 414 ? -18.148 13.576  -25.605 1.00 42.57  ? 414 LEU A CD2 1 
ATOM   3219  N N   . ARG A 1 415 ? -17.732 18.834  -24.997 1.00 36.51  ? 415 ARG A N   1 
ATOM   3220  C CA  . ARG A 1 415 ? -17.097 20.031  -24.463 1.00 40.93  ? 415 ARG A CA  1 
ATOM   3221  C C   . ARG A 1 415 ? -17.329 20.152  -22.964 1.00 43.02  ? 415 ARG A C   1 
ATOM   3222  O O   . ARG A 1 415 ? -18.218 19.534  -22.408 1.00 46.33  ? 415 ARG A O   1 
ATOM   3223  C CB  . ARG A 1 415 ? -17.608 21.357  -25.023 1.00 43.59  ? 415 ARG A CB  1 
ATOM   3224  C CG  . ARG A 1 415 ? -19.032 21.653  -24.602 1.00 50.09  ? 415 ARG A CG  1 
ATOM   3225  C CD  . ARG A 1 415 ? -19.591 22.852  -25.336 1.00 56.45  ? 415 ARG A CD  1 
ATOM   3226  N NE  . ARG A 1 415 ? -21.030 22.611  -25.468 1.00 63.04  ? 415 ARG A NE  1 
ATOM   3227  C CZ  . ARG A 1 415 ? -21.974 23.314  -24.893 1.00 65.15  ? 415 ARG A CZ  1 
ATOM   3228  N NH1 . ARG A 1 415 ? -21.657 24.370  -24.180 1.00 75.08  ? 415 ARG A NH1 1 
ATOM   3229  N NH2 . ARG A 1 415 ? -23.234 22.977  -25.051 1.00 67.32  ? 415 ARG A NH2 1 
ATOM   3230  N N   . GLY A 1 416 ? -16.513 20.987  -22.327 1.00 48.38  ? 416 GLY A N   1 
ATOM   3231  C CA  . GLY A 1 416 ? -16.691 21.338  -20.933 1.00 46.19  ? 416 GLY A CA  1 
ATOM   3232  C C   . GLY A 1 416 ? -17.060 22.808  -20.806 1.00 49.19  ? 416 GLY A C   1 
ATOM   3233  O O   . GLY A 1 416 ? -17.088 23.549  -21.797 1.00 47.52  ? 416 GLY A O   1 
ATOM   3234  N N   . THR A 1 417 ? -17.315 23.220  -19.568 1.00 49.02  ? 417 THR A N   1 
ATOM   3235  C CA  . THR A 1 417 ? -17.750 24.576  -19.299 1.00 49.92  ? 417 THR A CA  1 
ATOM   3236  C C   . THR A 1 417 ? -16.756 25.555  -19.896 1.00 48.82  ? 417 THR A C   1 
ATOM   3237  O O   . THR A 1 417 ? -17.148 26.577  -20.427 1.00 53.31  ? 417 THR A O   1 
ATOM   3238  C CB  . THR A 1 417 ? -17.857 24.789  -17.797 1.00 52.20  ? 417 THR A CB  1 
ATOM   3239  O OG1 . THR A 1 417 ? -18.659 23.684  -17.408 1.00 58.02  ? 417 THR A OG1 1 
ATOM   3240  C CG2 . THR A 1 417 ? -18.528 26.107  -17.463 1.00 55.68  ? 417 THR A CG2 1 
ATOM   3241  N N   . SER A 1 418 ? -15.468 25.255  -19.750 1.00 46.26  ? 418 SER A N   1 
ATOM   3242  C CA  . SER A 1 418 ? -14.453 26.252  -20.003 1.00 47.67  ? 418 SER A CA  1 
ATOM   3243  C C   . SER A 1 418 ? -13.328 25.644  -20.826 1.00 45.33  ? 418 SER A C   1 
ATOM   3244  O O   . SER A 1 418 ? -12.200 26.125  -20.758 1.00 44.10  ? 418 SER A O   1 
ATOM   3245  C CB  . SER A 1 418 ? -13.926 26.814  -18.696 1.00 53.19  ? 418 SER A CB  1 
ATOM   3246  O OG  . SER A 1 418 ? -14.973 27.290  -17.854 1.00 54.24  ? 418 SER A OG  1 
ATOM   3247  N N   . ILE A 1 419 ? -13.639 24.604  -21.607 1.00 38.16  ? 419 ILE A N   1 
ATOM   3248  C CA  . ILE A 1 419 ? -12.647 24.020  -22.492 1.00 38.46  ? 419 ILE A CA  1 
ATOM   3249  C C   . ILE A 1 419 ? -13.390 23.319  -23.610 1.00 34.89  ? 419 ILE A C   1 
ATOM   3250  O O   . ILE A 1 419 ? -14.401 22.696  -23.350 1.00 45.09  ? 419 ILE A O   1 
ATOM   3251  C CB  . ILE A 1 419 ? -11.713 23.056  -21.737 1.00 36.03  ? 419 ILE A CB  1 
ATOM   3252  C CG1 . ILE A 1 419 ? -10.701 22.444  -22.670 1.00 37.80  ? 419 ILE A CG1 1 
ATOM   3253  C CG2 . ILE A 1 419 ? -12.500 21.961  -21.035 1.00 37.59  ? 419 ILE A CG2 1 
ATOM   3254  C CD1 . ILE A 1 419 ? -9.605  21.666  -21.987 1.00 36.84  ? 419 ILE A CD1 1 
ATOM   3255  N N   . SER A 1 420 ? -12.925 23.465  -24.848 1.00 37.24  ? 420 SER A N   1 
ATOM   3256  C CA  . SER A 1 420 ? -13.579 22.835  -25.986 1.00 36.51  ? 420 SER A CA  1 
ATOM   3257  C C   . SER A 1 420 ? -13.415 21.318  -25.952 1.00 40.08  ? 420 SER A C   1 
ATOM   3258  O O   . SER A 1 420 ? -12.569 20.773  -25.243 1.00 43.37  ? 420 SER A O   1 
ATOM   3259  C CB  . SER A 1 420 ? -13.008 23.348  -27.257 1.00 36.35  ? 420 SER A CB  1 
ATOM   3260  O OG  . SER A 1 420 ? -11.665 22.907  -27.377 1.00 39.05  ? 420 SER A OG  1 
ATOM   3261  N N   . ALA A 1 421 ? -14.189 20.641  -26.795 1.00 35.40  ? 421 ALA A N   1 
ATOM   3262  C CA  . ALA A 1 421 ? -14.141 19.201  -26.878 1.00 33.12  ? 421 ALA A CA  1 
ATOM   3263  C C   . ALA A 1 421 ? -12.759 18.741  -27.298 1.00 36.21  ? 421 ALA A C   1 
ATOM   3264  O O   . ALA A 1 421 ? -12.249 17.758  -26.764 1.00 42.55  ? 421 ALA A O   1 
ATOM   3265  C CB  . ALA A 1 421 ? -15.135 18.740  -27.873 1.00 36.81  ? 421 ALA A CB  1 
ATOM   3266  N N   . ARG A 1 422 ? -12.200 19.440  -28.288 1.00 31.27  ? 422 ARG A N   1 
ATOM   3267  C CA  . ARG A 1 422 ? -10.963 19.048  -28.923 1.00 33.87  ? 422 ARG A CA  1 
ATOM   3268  C C   . ARG A 1 422 ? -9.815  19.188  -27.927 1.00 36.59  ? 422 ARG A C   1 
ATOM   3269  O O   . ARG A 1 422 ? -8.953  18.332  -27.816 1.00 40.49  ? 422 ARG A O   1 
ATOM   3270  C CB  . ARG A 1 422 ? -10.707 19.892  -30.175 1.00 33.32  ? 422 ARG A CB  1 
ATOM   3271  C CG  . ARG A 1 422 ? -11.616 19.585  -31.354 1.00 34.67  ? 422 ARG A CG  1 
ATOM   3272  C CD  . ARG A 1 422 ? -11.260 20.448  -32.556 1.00 35.60  ? 422 ARG A CD  1 
ATOM   3273  N NE  . ARG A 1 422 ? -12.184 20.313  -33.690 1.00 38.33  ? 422 ARG A NE  1 
ATOM   3274  C CZ  . ARG A 1 422 ? -11.976 19.712  -34.877 1.00 39.40  ? 422 ARG A CZ  1 
ATOM   3275  N NH1 . ARG A 1 422 ? -10.833 19.171  -35.199 1.00 41.45  ? 422 ARG A NH1 1 
ATOM   3276  N NH2 . ARG A 1 422 ? -12.921 19.674  -35.789 1.00 40.06  ? 422 ARG A NH2 1 
ATOM   3277  N N   . ASP A 1 423 ? -9.773  20.321  -27.240 1.00 40.29  ? 423 ASP A N   1 
ATOM   3278  C CA  . ASP A 1 423 ? -8.704  20.579  -26.307 1.00 36.10  ? 423 ASP A CA  1 
ATOM   3279  C C   . ASP A 1 423 ? -8.752  19.542  -25.195 1.00 39.42  ? 423 ASP A C   1 
ATOM   3280  O O   . ASP A 1 423 ? -7.725  19.011  -24.821 1.00 38.41  ? 423 ASP A O   1 
ATOM   3281  C CB  . ASP A 1 423 ? -8.842  21.977  -25.755 1.00 40.34  ? 423 ASP A CB  1 
ATOM   3282  C CG  . ASP A 1 423 ? -8.393  23.076  -26.694 1.00 39.44  ? 423 ASP A CG  1 
ATOM   3283  O OD1 . ASP A 1 423 ? -7.725  22.755  -27.677 1.00 44.06  ? 423 ASP A OD1 1 
ATOM   3284  O OD2 . ASP A 1 423 ? -8.703  24.234  -26.397 1.00 43.86  ? 423 ASP A OD2 1 
ATOM   3285  N N   . ARG A 1 424 ? -9.948  19.268  -24.667 1.00 37.34  ? 424 ARG A N   1 
ATOM   3286  C CA  . ARG A 1 424 ? -10.101 18.340  -23.565 1.00 34.36  ? 424 ARG A CA  1 
ATOM   3287  C C   . ARG A 1 424 ? -9.729  16.931  -24.015 1.00 34.42  ? 424 ARG A C   1 
ATOM   3288  O O   . ARG A 1 424 ? -9.041  16.213  -23.295 1.00 36.85  ? 424 ARG A O   1 
ATOM   3289  C CB  . ARG A 1 424 ? -11.519 18.394  -22.983 1.00 33.25  ? 424 ARG A CB  1 
ATOM   3290  C CG  . ARG A 1 424 ? -11.577 17.554  -21.718 1.00 36.38  ? 424 ARG A CG  1 
ATOM   3291  C CD  . ARG A 1 424 ? -12.700 17.856  -20.778 1.00 36.55  ? 424 ARG A CD  1 
ATOM   3292  N NE  . ARG A 1 424 ? -14.009 17.503  -21.321 1.00 41.30  ? 424 ARG A NE  1 
ATOM   3293  C CZ  . ARG A 1 424 ? -15.140 17.680  -20.648 1.00 42.23  ? 424 ARG A CZ  1 
ATOM   3294  N NH1 . ARG A 1 424 ? -15.107 18.214  -19.451 1.00 45.48  ? 424 ARG A NH1 1 
ATOM   3295  N NH2 . ARG A 1 424 ? -16.299 17.364  -21.183 1.00 44.66  ? 424 ARG A NH2 1 
ATOM   3296  N N   . VAL A 1 425 ? -10.120 16.535  -25.220 1.00 34.09  ? 425 VAL A N   1 
ATOM   3297  C CA  . VAL A 1 425 ? -9.782  15.193  -25.670 1.00 33.80  ? 425 VAL A CA  1 
ATOM   3298  C C   . VAL A 1 425 ? -8.273  15.096  -25.916 1.00 37.65  ? 425 VAL A C   1 
ATOM   3299  O O   . VAL A 1 425 ? -7.653  14.037  -25.791 1.00 35.67  ? 425 VAL A O   1 
ATOM   3300  C CB  . VAL A 1 425 ? -10.637 14.864  -26.892 1.00 31.73  ? 425 VAL A CB  1 
ATOM   3301  C CG1 . VAL A 1 425 ? -10.122 13.675  -27.669 1.00 34.63  ? 425 VAL A CG1 1 
ATOM   3302  C CG2 . VAL A 1 425 ? -12.079 14.627  -26.473 1.00 32.17  ? 425 VAL A CG2 1 
ATOM   3303  N N   . SER A 1 426 ? -7.637  16.232  -26.172 1.00 33.20  ? 426 SER A N   1 
ATOM   3304  C CA  . SER A 1 426 ? -6.208  16.185  -26.392 1.00 36.78  ? 426 SER A CA  1 
ATOM   3305  C C   . SER A 1 426 ? -5.504  15.888  -25.078 1.00 33.38  ? 426 SER A C   1 
ATOM   3306  O O   . SER A 1 426 ? -4.372  15.434  -25.101 1.00 34.62  ? 426 SER A O   1 
ATOM   3307  C CB  . SER A 1 426 ? -5.683  17.468  -27.067 1.00 35.90  ? 426 SER A CB  1 
ATOM   3308  O OG  . SER A 1 426 ? -5.651  18.523  -26.123 1.00 40.39  ? 426 SER A OG  1 
ATOM   3309  N N   . ILE A 1 427 ? -6.157  16.139  -23.933 1.00 33.16  ? 427 ILE A N   1 
ATOM   3310  C CA  . ILE A 1 427 ? -5.532  15.807  -22.671 1.00 32.06  ? 427 ILE A CA  1 
ATOM   3311  C C   . ILE A 1 427 ? -5.574  14.294  -22.495 1.00 33.88  ? 427 ILE A C   1 
ATOM   3312  O O   . ILE A 1 427 ? -4.597  13.675  -22.106 1.00 35.44  ? 427 ILE A O   1 
ATOM   3313  C CB  . ILE A 1 427 ? -6.167  16.512  -21.471 1.00 34.94  ? 427 ILE A CB  1 
ATOM   3314  C CG1 . ILE A 1 427 ? -6.262  18.031  -21.631 1.00 36.19  ? 427 ILE A CG1 1 
ATOM   3315  C CG2 . ILE A 1 427 ? -5.361  16.168  -20.220 1.00 35.19  ? 427 ILE A CG2 1 
ATOM   3316  C CD1 . ILE A 1 427 ? -6.995  18.711  -20.476 1.00 33.45  ? 427 ILE A CD1 1 
ATOM   3317  N N   . PHE A 1 428 ? -6.721  13.707  -22.785 1.00 34.61  ? 428 PHE A N   1 
ATOM   3318  C CA  . PHE A 1 428 ? -6.863  12.269  -22.720 1.00 37.69  ? 428 PHE A CA  1 
ATOM   3319  C C   . PHE A 1 428 ? -5.825  11.621  -23.630 1.00 36.36  ? 428 PHE A C   1 
ATOM   3320  O O   . PHE A 1 428 ? -5.102  10.734  -23.201 1.00 37.05  ? 428 PHE A O   1 
ATOM   3321  C CB  . PHE A 1 428 ? -8.292  11.876  -23.086 1.00 36.38  ? 428 PHE A CB  1 
ATOM   3322  C CG  . PHE A 1 428 ? -9.417  12.318  -22.161 1.00 35.14  ? 428 PHE A CG  1 
ATOM   3323  C CD1 . PHE A 1 428 ? -9.398  12.049  -20.815 1.00 42.02  ? 428 PHE A CD1 1 
ATOM   3324  C CD2 . PHE A 1 428 ? -10.565 12.904  -22.681 1.00 45.53  ? 428 PHE A CD2 1 
ATOM   3325  C CE1 . PHE A 1 428 ? -10.467 12.410  -20.002 1.00 43.98  ? 428 PHE A CE1 1 
ATOM   3326  C CE2 . PHE A 1 428 ? -11.618 13.283  -21.865 1.00 45.51  ? 428 PHE A CE2 1 
ATOM   3327  C CZ  . PHE A 1 428 ? -11.562 13.028  -20.523 1.00 45.48  ? 428 PHE A CZ  1 
ATOM   3328  N N   . ARG A 1 429 ? -5.730  12.091  -24.872 1.00 37.88  ? 429 ARG A N   1 
ATOM   3329  C CA  . ARG A 1 429 ? -4.863  11.468  -25.858 1.00 33.17  ? 429 ARG A CA  1 
ATOM   3330  C C   . ARG A 1 429 ? -3.387  11.577  -25.478 1.00 36.20  ? 429 ARG A C   1 
ATOM   3331  O O   . ARG A 1 429 ? -2.606  10.663  -25.752 1.00 39.90  ? 429 ARG A O   1 
ATOM   3332  C CB  . ARG A 1 429 ? -5.112  12.112  -27.217 1.00 31.45  ? 429 ARG A CB  1 
ATOM   3333  C CG  . ARG A 1 429 ? -6.272  11.415  -27.899 1.00 34.59  ? 429 ARG A CG  1 
ATOM   3334  C CD  . ARG A 1 429 ? -6.565  11.948  -29.269 1.00 35.48  ? 429 ARG A CD  1 
ATOM   3335  N NE  . ARG A 1 429 ? -7.629  11.142  -29.863 1.00 38.20  ? 429 ARG A NE  1 
ATOM   3336  C CZ  . ARG A 1 429 ? -7.435  9.952   -30.369 1.00 38.60  ? 429 ARG A CZ  1 
ATOM   3337  N NH1 . ARG A 1 429 ? -6.207  9.468   -30.488 1.00 36.27  ? 429 ARG A NH1 1 
ATOM   3338  N NH2 . ARG A 1 429 ? -8.477  9.273   -30.783 1.00 41.15  ? 429 ARG A NH2 1 
ATOM   3339  N N   . GLN A 1 430 ? -3.009  12.668  -24.817 1.00 29.14  ? 430 GLN A N   1 
ATOM   3340  C CA  . GLN A 1 430 ? -1.641  12.806  -24.328 1.00 32.38  ? 430 GLN A CA  1 
ATOM   3341  C C   . GLN A 1 430 ? -1.369  11.778  -23.229 1.00 34.46  ? 430 GLN A C   1 
ATOM   3342  O O   . GLN A 1 430 ? -0.282  11.217  -23.154 1.00 32.86  ? 430 GLN A O   1 
ATOM   3343  C CB  . GLN A 1 430 ? -1.505  14.241  -23.837 1.00 30.96  ? 430 GLN A CB  1 
ATOM   3344  C CG  . GLN A 1 430 ? -0.169  14.621  -23.237 1.00 33.34  ? 430 GLN A CG  1 
ATOM   3345  C CD  . GLN A 1 430 ? 0.972   14.763  -24.227 1.00 32.95  ? 430 GLN A CD  1 
ATOM   3346  O OE1 . GLN A 1 430 ? 2.132   14.508  -23.884 1.00 31.92  ? 430 GLN A OE1 1 
ATOM   3347  N NE2 . GLN A 1 430 ? 0.688   15.270  -25.413 1.00 32.37  ? 430 GLN A NE2 1 
ATOM   3348  N N   . ILE A 1 431 ? -2.371  11.526  -22.387 1.00 30.46  ? 431 ILE A N   1 
ATOM   3349  C CA  . ILE A 1 431 ? -2.258  10.533  -21.347 1.00 33.56  ? 431 ILE A CA  1 
ATOM   3350  C C   . ILE A 1 431 ? -2.287  9.131   -21.974 1.00 36.59  ? 431 ILE A C   1 
ATOM   3351  O O   . ILE A 1 431 ? -1.487  8.299   -21.622 1.00 40.37  ? 431 ILE A O   1 
ATOM   3352  C CB  . ILE A 1 431 ? -3.352  10.764  -20.301 1.00 33.93  ? 431 ILE A CB  1 
ATOM   3353  C CG1 . ILE A 1 431 ? -3.129  12.062  -19.564 1.00 34.99  ? 431 ILE A CG1 1 
ATOM   3354  C CG2 . ILE A 1 431 ? -3.458  9.594   -19.334 1.00 37.86  ? 431 ILE A CG2 1 
ATOM   3355  C CD1 . ILE A 1 431 ? -4.257  12.424  -18.616 1.00 33.51  ? 431 ILE A CD1 1 
ATOM   3356  N N   . SER A 1 432 ? -3.158  8.863   -22.938 1.00 41.17  ? 432 SER A N   1 
ATOM   3357  C CA  . SER A 1 432 ? -3.213  7.555   -23.593 1.00 44.32  ? 432 SER A CA  1 
ATOM   3358  C C   . SER A 1 432 ? -1.911  7.213   -24.314 1.00 34.80  ? 432 SER A C   1 
ATOM   3359  O O   . SER A 1 432 ? -1.490  6.063   -24.339 1.00 36.19  ? 432 SER A O   1 
ATOM   3360  C CB  . SER A 1 432 ? -4.348  7.464   -24.592 1.00 40.22  ? 432 SER A CB  1 
ATOM   3361  O OG  . SER A 1 432 ? -5.545  7.198   -23.894 1.00 56.06  ? 432 SER A OG  1 
ATOM   3362  N N   . GLU A 1 433 ? -1.365  8.191   -25.010 1.00 30.00  ? 433 GLU A N   1 
ATOM   3363  C CA  . GLU A 1 433 ? -0.158  7.981   -25.787 1.00 34.00  ? 433 GLU A CA  1 
ATOM   3364  C C   . GLU A 1 433 ? 0.979   7.532   -24.867 1.00 32.27  ? 433 GLU A C   1 
ATOM   3365  O O   . GLU A 1 433 ? 1.704   6.594   -25.159 1.00 34.98  ? 433 GLU A O   1 
ATOM   3366  C CB  . GLU A 1 433 ? 0.077   9.333   -26.455 1.00 35.43  ? 433 GLU A CB  1 
ATOM   3367  C CG  . GLU A 1 433 ? 1.205   9.369   -27.461 1.00 36.84  ? 433 GLU A CG  1 
ATOM   3368  C CD  . GLU A 1 433 ? 0.843   8.877   -28.841 1.00 37.46  ? 433 GLU A CD  1 
ATOM   3369  O OE1 . GLU A 1 433 ? 0.132   7.864   -28.924 1.00 42.24  ? 433 GLU A OE1 1 
ATOM   3370  O OE2 . GLU A 1 433 ? 1.363   9.472   -29.817 1.00 37.90  ? 433 GLU A OE2 1 
ATOM   3371  N N   . ARG A 1 434 ? 1.115   8.188   -23.721 1.00 33.23  ? 434 ARG A N   1 
ATOM   3372  C CA  . ARG A 1 434 ? 2.256   7.967   -22.851 1.00 31.01  ? 434 ARG A CA  1 
ATOM   3373  C C   . ARG A 1 434 ? 2.053   6.705   -22.023 1.00 32.84  ? 434 ARG A C   1 
ATOM   3374  O O   . ARG A 1 434 ? 3.032   6.035   -21.740 1.00 37.30  ? 434 ARG A O   1 
ATOM   3375  C CB  . ARG A 1 434 ? 2.437   9.087   -21.819 1.00 28.59  ? 434 ARG A CB  1 
ATOM   3376  C CG  . ARG A 1 434 ? 2.892   10.405  -22.424 1.00 29.38  ? 434 ARG A CG  1 
ATOM   3377  C CD  . ARG A 1 434 ? 2.649   11.550  -21.472 1.00 28.31  ? 434 ARG A CD  1 
ATOM   3378  N NE  . ARG A 1 434 ? 3.100   12.798  -22.063 1.00 28.33  ? 434 ARG A NE  1 
ATOM   3379  C CZ  . ARG A 1 434 ? 4.393   13.078  -22.166 1.00 33.42  ? 434 ARG A CZ  1 
ATOM   3380  N NH1 . ARG A 1 434 ? 5.281   12.355  -21.496 1.00 26.23  ? 434 ARG A NH1 1 
ATOM   3381  N NH2 . ARG A 1 434 ? 4.766   14.113  -22.896 1.00 33.44  ? 434 ARG A NH2 1 
ATOM   3382  N N   . TYR A 1 435 ? 0.814   6.402   -21.588 1.00 31.28  ? 435 TYR A N   1 
ATOM   3383  C CA  . TYR A 1 435 ? 0.651   5.309   -20.637 1.00 31.79  ? 435 TYR A CA  1 
ATOM   3384  C C   . TYR A 1 435 ? -0.219  4.142   -21.123 1.00 32.88  ? 435 TYR A C   1 
ATOM   3385  O O   . TYR A 1 435 ? -0.432  3.215   -20.361 1.00 37.55  ? 435 TYR A O   1 
ATOM   3386  C CB  . TYR A 1 435 ? 0.205   5.905   -19.307 1.00 24.79  ? 435 TYR A CB  1 
ATOM   3387  C CG  . TYR A 1 435 ? 1.035   7.094   -18.865 1.00 26.34  ? 435 TYR A CG  1 
ATOM   3388  C CD1 . TYR A 1 435 ? 2.373   6.960   -18.563 1.00 31.56  ? 435 TYR A CD1 1 
ATOM   3389  C CD2 . TYR A 1 435 ? 0.494   8.354   -18.768 1.00 25.01  ? 435 TYR A CD2 1 
ATOM   3390  C CE1 . TYR A 1 435 ? 3.136   8.055   -18.207 1.00 26.19  ? 435 TYR A CE1 1 
ATOM   3391  C CE2 . TYR A 1 435 ? 1.247   9.461   -18.445 1.00 28.57  ? 435 TYR A CE2 1 
ATOM   3392  C CZ  . TYR A 1 435 ? 2.579   9.304   -18.147 1.00 26.71  ? 435 TYR A CZ  1 
ATOM   3393  O OH  . TYR A 1 435 ? 3.333   10.388  -17.802 1.00 29.36  ? 435 TYR A OH  1 
ATOM   3394  N N   . LEU A 1 436 ? -0.761  4.184   -22.342 1.00 34.16  ? 436 LEU A N   1 
ATOM   3395  C CA  . LEU A 1 436 ? -1.696  3.168   -22.794 1.00 30.14  ? 436 LEU A CA  1 
ATOM   3396  C C   . LEU A 1 436 ? -1.435  2.790   -24.253 1.00 30.40  ? 436 LEU A C   1 
ATOM   3397  O O   . LEU A 1 436 ? -2.350  2.364   -24.927 1.00 35.05  ? 436 LEU A O   1 
ATOM   3398  C CB  . LEU A 1 436 ? -3.136  3.653   -22.612 1.00 31.04  ? 436 LEU A CB  1 
ATOM   3399  C CG  . LEU A 1 436 ? -3.591  3.966   -21.181 1.00 33.97  ? 436 LEU A CG  1 
ATOM   3400  C CD1 . LEU A 1 436 ? -4.963  4.538   -21.232 1.00 31.05  ? 436 LEU A CD1 1 
ATOM   3401  C CD2 . LEU A 1 436 ? -3.589  2.735   -20.285 1.00 35.01  ? 436 LEU A CD2 1 
ATOM   3402  N N   . THR A 1 437 ? -0.188  2.878   -24.720 1.00 31.20  ? 437 THR A N   1 
ATOM   3403  C CA  . THR A 1 437 ? 0.200   2.471   -26.062 1.00 29.03  ? 437 THR A CA  1 
ATOM   3404  C C   . THR A 1 437 ? 1.473   1.672   -25.907 1.00 29.42  ? 437 THR A C   1 
ATOM   3405  O O   . THR A 1 437 ? 2.113   1.805   -24.885 1.00 32.13  ? 437 THR A O   1 
ATOM   3406  C CB  . THR A 1 437 ? 0.471   3.656   -26.988 1.00 30.18  ? 437 THR A CB  1 
ATOM   3407  O OG1 . THR A 1 437 ? 1.471   4.449   -26.354 1.00 30.16  ? 437 THR A OG1 1 
ATOM   3408  C CG2 . THR A 1 437 ? -0.750  4.529   -27.222 1.00 29.99  ? 437 THR A CG2 1 
ATOM   3409  N N   . GLN A 1 438 ? 1.825   0.883   -26.919 1.00 35.14  ? 438 GLN A N   1 
ATOM   3410  C CA  . GLN A 1 438 ? 3.098   0.190   -26.974 1.00 35.30  ? 438 GLN A CA  1 
ATOM   3411  C C   . GLN A 1 438 ? 4.182   1.269   -26.975 1.00 31.52  ? 438 GLN A C   1 
ATOM   3412  O O   . GLN A 1 438 ? 5.134   1.210   -26.208 1.00 30.62  ? 438 GLN A O   1 
ATOM   3413  C CB  . GLN A 1 438 ? 3.142   -0.745  -28.191 1.00 37.70  ? 438 GLN A CB  1 
ATOM   3414  C CG  . GLN A 1 438 ? 3.853   -2.070  -27.907 1.00 57.43  ? 438 GLN A CG  1 
ATOM   3415  C CD  . GLN A 1 438 ? 4.213   -2.930  -29.116 1.00 61.09  ? 438 GLN A CD  1 
ATOM   3416  O OE1 . GLN A 1 438 ? 3.363   -3.396  -29.887 1.00 66.68  ? 438 GLN A OE1 1 
ATOM   3417  N NE2 . GLN A 1 438 ? 5.502   -3.196  -29.273 1.00 71.16  ? 438 GLN A NE2 1 
ATOM   3418  N N   . TRP A 1 439 ? 3.987   2.296   -27.804 1.00 33.25  ? 439 TRP A N   1 
ATOM   3419  C CA  . TRP A 1 439 ? 4.915   3.415   -27.868 1.00 33.48  ? 439 TRP A CA  1 
ATOM   3420  C C   . TRP A 1 439 ? 5.257   3.880   -26.460 1.00 31.11  ? 439 TRP A C   1 
ATOM   3421  O O   . TRP A 1 439 ? 6.427   3.943   -26.091 1.00 31.55  ? 439 TRP A O   1 
ATOM   3422  C CB  . TRP A 1 439 ? 4.360   4.574   -28.702 1.00 31.48  ? 439 TRP A CB  1 
ATOM   3423  C CG  . TRP A 1 439 ? 5.327   5.706   -28.824 1.00 30.65  ? 439 TRP A CG  1 
ATOM   3424  C CD1 . TRP A 1 439 ? 6.282   5.860   -29.779 1.00 34.11  ? 439 TRP A CD1 1 
ATOM   3425  C CD2 . TRP A 1 439 ? 5.481   6.807   -27.919 1.00 32.02  ? 439 TRP A CD2 1 
ATOM   3426  N NE1 . TRP A 1 439 ? 7.015   6.990   -29.547 1.00 32.84  ? 439 TRP A NE1 1 
ATOM   3427  C CE2 . TRP A 1 439 ? 6.558   7.586   -28.407 1.00 33.11  ? 439 TRP A CE2 1 
ATOM   3428  C CE3 . TRP A 1 439 ? 4.841   7.197   -26.741 1.00 33.66  ? 439 TRP A CE3 1 
ATOM   3429  C CZ2 . TRP A 1 439 ? 6.978   8.753   -27.778 1.00 31.57  ? 439 TRP A CZ2 1 
ATOM   3430  C CZ3 . TRP A 1 439 ? 5.271   8.347   -26.114 1.00 36.87  ? 439 TRP A CZ3 1 
ATOM   3431  C CH2 . TRP A 1 439 ? 6.340   9.095   -26.610 1.00 33.19  ? 439 TRP A CH2 1 
ATOM   3432  N N   . GLY A 1 440 ? 4.236   4.190   -25.664 1.00 30.09  ? 440 GLY A N   1 
ATOM   3433  C CA  . GLY A 1 440 ? 4.481   4.758   -24.341 1.00 31.42  ? 440 GLY A CA  1 
ATOM   3434  C C   . GLY A 1 440 ? 4.966   3.710   -23.339 1.00 32.21  ? 440 GLY A C   1 
ATOM   3435  O O   . GLY A 1 440 ? 5.729   4.001   -22.422 1.00 34.63  ? 440 GLY A O   1 
ATOM   3436  N N   . ALA A 1 441 ? 4.508   2.472   -23.518 1.00 32.67  ? 441 ALA A N   1 
ATOM   3437  C CA  . ALA A 1 441 ? 4.817   1.400   -22.594 1.00 32.16  ? 441 ALA A CA  1 
ATOM   3438  C C   . ALA A 1 441 ? 6.323   1.183   -22.549 1.00 31.35  ? 441 ALA A C   1 
ATOM   3439  O O   . ALA A 1 441 ? 6.885   0.880   -21.513 1.00 32.56  ? 441 ALA A O   1 
ATOM   3440  C CB  . ALA A 1 441 ? 4.070   0.159   -23.008 1.00 33.82  ? 441 ALA A CB  1 
ATOM   3441  N N   . ARG A 1 442 ? 6.993   1.339   -23.689 1.00 39.20  ? 442 ARG A N   1 
ATOM   3442  C CA  . ARG A 1 442 ? 8.441   1.222   -23.691 1.00 37.27  ? 442 ARG A CA  1 
ATOM   3443  C C   . ARG A 1 442 ? 9.051   2.215   -22.707 1.00 40.89  ? 442 ARG A C   1 
ATOM   3444  O O   . ARG A 1 442 ? 10.000  1.882   -22.032 1.00 42.68  ? 442 ARG A O   1 
ATOM   3445  C CB  . ARG A 1 442 ? 9.050   1.443   -25.071 1.00 35.87  ? 442 ARG A CB  1 
ATOM   3446  C CG  . ARG A 1 442 ? 10.574  1.476   -25.086 1.00 41.33  ? 442 ARG A CG  1 
ATOM   3447  C CD  . ARG A 1 442 ? 11.214  2.862   -25.001 1.00 44.43  ? 442 ARG A CD  1 
ATOM   3448  N NE  . ARG A 1 442 ? 12.690  2.902   -25.063 1.00 42.67  ? 442 ARG A NE  1 
ATOM   3449  C CZ  . ARG A 1 442 ? 13.347  4.041   -24.842 1.00 46.03  ? 442 ARG A CZ  1 
ATOM   3450  N NH1 . ARG A 1 442 ? 12.676  5.175   -24.679 1.00 42.92  ? 442 ARG A NH1 1 
ATOM   3451  N NH2 . ARG A 1 442 ? 14.662  4.070   -24.837 1.00 49.65  ? 442 ARG A NH2 1 
ATOM   3452  N N   . HIS A 1 443 ? 8.531   3.440   -22.632 1.00 40.86  ? 443 HIS A N   1 
ATOM   3453  C CA  . HIS A 1 443 ? 9.129   4.424   -21.747 1.00 42.10  ? 443 HIS A CA  1 
ATOM   3454  C C   . HIS A 1 443 ? 9.126   3.882   -20.316 1.00 42.42  ? 443 HIS A C   1 
ATOM   3455  O O   . HIS A 1 443 ? 10.159  3.762   -19.642 1.00 40.45  ? 443 HIS A O   1 
ATOM   3456  C CB  . HIS A 1 443 ? 8.429   5.781   -21.886 1.00 41.96  ? 443 HIS A CB  1 
ATOM   3457  C CG  . HIS A 1 443 ? 8.896   6.771   -20.875 1.00 44.35  ? 443 HIS A CG  1 
ATOM   3458  N ND1 . HIS A 1 443 ? 8.320   6.861   -19.628 1.00 45.02  ? 443 HIS A ND1 1 
ATOM   3459  C CD2 . HIS A 1 443 ? 9.894   7.681   -20.891 1.00 46.67  ? 443 HIS A CD2 1 
ATOM   3460  C CE1 . HIS A 1 443 ? 8.942   7.813   -18.922 1.00 47.19  ? 443 HIS A CE1 1 
ATOM   3461  N NE2 . HIS A 1 443 ? 9.903   8.324   -19.668 1.00 48.29  ? 443 HIS A NE2 1 
ATOM   3462  N N   . GLU A 1 444 ? 7.932   3.523   -19.867 1.00 38.02  ? 444 GLU A N   1 
ATOM   3463  C CA  . GLU A 1 444 ? 7.751   3.012   -18.531 1.00 41.76  ? 444 GLU A CA  1 
ATOM   3464  C C   . GLU A 1 444 ? 8.630   1.774   -18.356 1.00 46.84  ? 444 GLU A C   1 
ATOM   3465  O O   . GLU A 1 444 ? 9.268   1.641   -17.314 1.00 50.03  ? 444 GLU A O   1 
ATOM   3466  C CB  . GLU A 1 444 ? 6.269   2.729   -18.229 1.00 42.18  ? 444 GLU A CB  1 
ATOM   3467  C CG  . GLU A 1 444 ? 5.365   3.935   -18.426 1.00 39.28  ? 444 GLU A CG  1 
ATOM   3468  C CD  . GLU A 1 444 ? 5.874   5.173   -17.717 1.00 42.24  ? 444 GLU A CD  1 
ATOM   3469  O OE1 . GLU A 1 444 ? 5.854   5.107   -16.486 1.00 39.25  ? 444 GLU A OE1 1 
ATOM   3470  O OE2 . GLU A 1 444 ? 6.264   6.169   -18.363 1.00 44.66  ? 444 GLU A OE2 1 
ATOM   3471  N N   . MET A 1 445 ? 8.699   0.882   -19.361 1.00 46.07  ? 445 MET A N   1 
ATOM   3472  C CA  . MET A 1 445 ? 9.466   -0.335  -19.149 1.00 45.64  ? 445 MET A CA  1 
ATOM   3473  C C   . MET A 1 445 ? 10.965  -0.033  -19.040 1.00 46.49  ? 445 MET A C   1 
ATOM   3474  O O   . MET A 1 445 ? 11.688  -0.683  -18.265 1.00 37.94  ? 445 MET A O   1 
ATOM   3475  C CB  . MET A 1 445 ? 9.186   -1.375  -20.229 1.00 43.17  ? 445 MET A CB  1 
ATOM   3476  C CG  . MET A 1 445 ? 7.804   -1.962  -20.156 1.00 42.04  ? 445 MET A CG  1 
ATOM   3477  S SD  . MET A 1 445 ? 7.403   -2.456  -18.475 1.00 43.92  ? 445 MET A SD  1 
ATOM   3478  C CE  . MET A 1 445 ? 6.471   -1.104  -17.758 1.00 45.03  ? 445 MET A CE  1 
ATOM   3479  N N   . PHE A 1 446 ? 11.421  0.961   -19.808 1.00 47.56  ? 446 PHE A N   1 
ATOM   3480  C CA  . PHE A 1 446 ? 12.812  1.393   -19.782 1.00 50.59  ? 446 PHE A CA  1 
ATOM   3481  C C   . PHE A 1 446 ? 13.137  1.916   -18.385 1.00 46.32  ? 446 PHE A C   1 
ATOM   3482  O O   . PHE A 1 446 ? 14.102  1.502   -17.785 1.00 43.39  ? 446 PHE A O   1 
ATOM   3483  C CB  . PHE A 1 446 ? 13.084  2.477   -20.832 1.00 48.17  ? 446 PHE A CB  1 
ATOM   3484  C CG  . PHE A 1 446 ? 14.494  3.047   -20.740 1.00 55.78  ? 446 PHE A CG  1 
ATOM   3485  C CD1 . PHE A 1 446 ? 14.786  4.088   -19.849 1.00 57.69  ? 446 PHE A CD1 1 
ATOM   3486  C CD2 . PHE A 1 446 ? 15.526  2.561   -21.550 1.00 46.21  ? 446 PHE A CD2 1 
ATOM   3487  C CE1 . PHE A 1 446 ? 16.082  4.602   -19.742 1.00 46.84  ? 446 PHE A CE1 1 
ATOM   3488  C CE2 . PHE A 1 446 ? 16.810  3.078   -21.429 1.00 49.08  ? 446 PHE A CE2 1 
ATOM   3489  C CZ  . PHE A 1 446 ? 17.085  4.096   -20.520 1.00 45.34  ? 446 PHE A CZ  1 
ATOM   3490  N N   . GLU A 1 447 ? 12.310  2.824   -17.867 1.00 45.70  ? 447 GLU A N   1 
ATOM   3491  C CA  . GLU A 1 447 ? 12.522  3.386   -16.543 1.00 45.29  ? 447 GLU A CA  1 
ATOM   3492  C C   . GLU A 1 447 ? 12.544  2.279   -15.484 1.00 45.38  ? 447 GLU A C   1 
ATOM   3493  O O   . GLU A 1 447 ? 13.253  2.379   -14.477 1.00 43.17  ? 447 GLU A O   1 
ATOM   3494  C CB  . GLU A 1 447 ? 11.486  4.452   -16.161 1.00 39.89  ? 447 GLU A CB  1 
ATOM   3495  C CG  . GLU A 1 447 ? 11.517  5.731   -17.002 1.00 42.48  ? 447 GLU A CG  1 
ATOM   3496  C CD  . GLU A 1 447 ? 12.760  6.618   -16.892 1.00 43.35  ? 447 GLU A CD  1 
ATOM   3497  O OE1 . GLU A 1 447 ? 13.889  6.117   -16.774 1.00 48.69  ? 447 GLU A OE1 1 
ATOM   3498  O OE2 . GLU A 1 447 ? 12.610  7.833   -16.984 1.00 47.69  ? 447 GLU A OE2 1 
ATOM   3499  N N   . LYS A 1 448 ? 11.778  1.212   -15.698 1.00 46.50  ? 448 LYS A N   1 
ATOM   3500  C CA  . LYS A 1 448 ? 11.708  0.160   -14.694 1.00 48.58  ? 448 LYS A CA  1 
ATOM   3501  C C   . LYS A 1 448 ? 13.035  -0.608  -14.651 1.00 43.35  ? 448 LYS A C   1 
ATOM   3502  O O   . LYS A 1 448 ? 13.527  -0.909  -13.571 1.00 49.49  ? 448 LYS A O   1 
ATOM   3503  C CB  . LYS A 1 448 ? 10.398  -0.599  -14.933 1.00 50.67  ? 448 LYS A CB  1 
ATOM   3504  C CG  . LYS A 1 448 ? 9.857   -1.392  -13.759 1.00 65.94  ? 448 LYS A CG  1 
ATOM   3505  C CD  . LYS A 1 448 ? 8.419   -1.911  -13.885 1.00 73.77  ? 448 LYS A CD  1 
ATOM   3506  C CE  . LYS A 1 448 ? 7.386   -0.893  -13.538 1.00 79.19  ? 448 LYS A CE  1 
ATOM   3507  N NZ  . LYS A 1 448 ? 7.469   -0.447  -12.146 1.00 76.41  ? 448 LYS A NZ  1 
ATOM   3508  N N   . PHE A 1 449 ? 13.636  -0.914  -15.805 1.00 41.22  ? 449 PHE A N   1 
ATOM   3509  C CA  . PHE A 1 449 ? 14.732  -1.867  -15.857 1.00 47.62  ? 449 PHE A CA  1 
ATOM   3510  C C   . PHE A 1 449 ? 16.032  -1.201  -16.299 1.00 52.24  ? 449 PHE A C   1 
ATOM   3511  O O   . PHE A 1 449 ? 16.948  -1.882  -16.721 1.00 52.72  ? 449 PHE A O   1 
ATOM   3512  C CB  . PHE A 1 449 ? 14.342  -2.998  -16.814 1.00 52.94  ? 449 PHE A CB  1 
ATOM   3513  C CG  . PHE A 1 449 ? 13.074  -3.743  -16.410 1.00 51.14  ? 449 PHE A CG  1 
ATOM   3514  C CD1 . PHE A 1 449 ? 13.048  -4.511  -15.254 1.00 49.18  ? 449 PHE A CD1 1 
ATOM   3515  C CD2 . PHE A 1 449 ? 11.918  -3.669  -17.182 1.00 52.45  ? 449 PHE A CD2 1 
ATOM   3516  C CE1 . PHE A 1 449 ? 11.888  -5.165  -14.875 1.00 49.53  ? 449 PHE A CE1 1 
ATOM   3517  C CE2 . PHE A 1 449 ? 10.764  -4.327  -16.803 1.00 48.60  ? 449 PHE A CE2 1 
ATOM   3518  C CZ  . PHE A 1 449 ? 10.755  -5.076  -15.656 1.00 55.71  ? 449 PHE A CZ  1 
ATOM   3519  N N   . ASN A 1 450 ? 16.047  0.133   -16.252 1.00 63.67  ? 450 ASN A N   1 
ATOM   3520  C CA  . ASN A 1 450 ? 17.197  0.996   -16.480 1.00 69.97  ? 450 ASN A CA  1 
ATOM   3521  C C   . ASN A 1 450 ? 18.179  0.856   -15.323 1.00 65.55  ? 450 ASN A C   1 
ATOM   3522  O O   . ASN A 1 450 ? 17.801  1.066   -14.176 1.00 80.14  ? 450 ASN A O   1 
ATOM   3523  C CB  . ASN A 1 450 ? 16.712  2.450   -16.527 1.00 72.03  ? 450 ASN A CB  1 
ATOM   3524  C CG  . ASN A 1 450 ? 17.814  3.471   -16.671 1.00 67.07  ? 450 ASN A CG  1 
ATOM   3525  O OD1 . ASN A 1 450 ? 17.737  4.569   -16.103 1.00 66.58  ? 450 ASN A OD1 1 
ATOM   3526  N ND2 . ASN A 1 450 ? 18.805  3.150   -17.483 1.00 58.43  ? 450 ASN A ND2 1 
ATOM   3527  N N   . GLY A 1 451 ? 19.432  0.513   -15.603 1.00 65.48  ? 451 GLY A N   1 
ATOM   3528  C CA  . GLY A 1 451 ? 20.394  0.275   -14.529 1.00 71.72  ? 451 GLY A CA  1 
ATOM   3529  C C   . GLY A 1 451 ? 19.811  -0.570  -13.388 1.00 59.51  ? 451 GLY A C   1 
ATOM   3530  O O   . GLY A 1 451 ? 19.022  -1.480  -13.611 1.00 59.06  ? 451 GLY A O   1 
ATOM   3531  N N   . THR A 1 452 ? 20.144  -0.205  -12.150 1.00 52.58  ? 452 THR A N   1 
ATOM   3532  C CA  . THR A 1 452 ? 19.820  -0.999  -10.974 1.00 53.01  ? 452 THR A CA  1 
ATOM   3533  C C   . THR A 1 452 ? 18.323  -0.966  -10.687 1.00 47.06  ? 452 THR A C   1 
ATOM   3534  O O   . THR A 1 452 ? 17.777  0.060   -10.348 1.00 40.97  ? 452 THR A O   1 
ATOM   3535  C CB  . THR A 1 452 ? 20.620  -0.458  -9.801  1.00 57.46  ? 452 THR A CB  1 
ATOM   3536  O OG1 . THR A 1 452 ? 21.971  -0.563  -10.246 1.00 54.63  ? 452 THR A OG1 1 
ATOM   3537  C CG2 . THR A 1 452 ? 20.394  -1.262  -8.537  1.00 66.52  ? 452 THR A CG2 1 
ATOM   3538  N N   . PRO A 1 453 ? 17.571  -2.070  -10.841 1.00 49.74  ? 453 PRO A N   1 
ATOM   3539  C CA  . PRO A 1 453 ? 16.152  -2.041  -10.477 1.00 47.95  ? 453 PRO A CA  1 
ATOM   3540  C C   . PRO A 1 453 ? 15.895  -2.149  -8.969  1.00 45.74  ? 453 PRO A C   1 
ATOM   3541  O O   . PRO A 1 453 ? 16.782  -2.477  -8.194  1.00 45.87  ? 453 PRO A O   1 
ATOM   3542  C CB  . PRO A 1 453 ? 15.606  -3.240  -11.278 1.00 53.10  ? 453 PRO A CB  1 
ATOM   3543  C CG  . PRO A 1 453 ? 16.770  -4.222  -11.314 1.00 56.95  ? 453 PRO A CG  1 
ATOM   3544  C CD  . PRO A 1 453 ? 18.017  -3.347  -11.423 1.00 49.38  ? 453 PRO A CD  1 
ATOM   3545  N N   . LEU A 1 454 ? 14.653  -1.882  -8.570  1.00 44.76  ? 454 LEU A N   1 
ATOM   3546  C CA  . LEU A 1 454 ? 14.282  -1.688  -7.182  1.00 45.14  ? 454 LEU A CA  1 
ATOM   3547  C C   . LEU A 1 454 ? 14.772  -2.850  -6.329  1.00 42.37  ? 454 LEU A C   1 
ATOM   3548  O O   . LEU A 1 454 ? 15.386  -2.614  -5.287  1.00 40.36  ? 454 LEU A O   1 
ATOM   3549  C CB  . LEU A 1 454 ? 12.767  -1.500  -7.103  1.00 43.91  ? 454 LEU A CB  1 
ATOM   3550  C CG  . LEU A 1 454 ? 12.146  -1.329  -5.715  1.00 44.39  ? 454 LEU A CG  1 
ATOM   3551  C CD1 . LEU A 1 454 ? 12.595  -0.085  -4.982  1.00 45.96  ? 454 LEU A CD1 1 
ATOM   3552  C CD2 . LEU A 1 454 ? 10.614  -1.311  -5.858  1.00 47.64  ? 454 LEU A CD2 1 
ATOM   3553  N N   . TYR A 1 455 ? 14.537  -4.098  -6.771  1.00 45.33  ? 455 TYR A N   1 
ATOM   3554  C CA  . TYR A 1 455 ? 14.820  -5.233  -5.899  1.00 44.89  ? 455 TYR A CA  1 
ATOM   3555  C C   . TYR A 1 455 ? 16.319  -5.252  -5.618  1.00 45.25  ? 455 TYR A C   1 
ATOM   3556  O O   . TYR A 1 455 ? 16.723  -5.684  -4.549  1.00 49.26  ? 455 TYR A O   1 
ATOM   3557  C CB  . TYR A 1 455 ? 14.380  -6.624  -6.359  1.00 52.93  ? 455 TYR A CB  1 
ATOM   3558  C CG  . TYR A 1 455 ? 15.371  -7.342  -7.254  1.00 63.10  ? 455 TYR A CG  1 
ATOM   3559  C CD1 . TYR A 1 455 ? 15.555  -6.928  -8.565  1.00 77.34  ? 455 TYR A CD1 1 
ATOM   3560  C CD2 . TYR A 1 455 ? 16.106  -8.431  -6.799  1.00 69.20  ? 455 TYR A CD2 1 
ATOM   3561  C CE1 . TYR A 1 455 ? 16.452  -7.567  -9.405  1.00 87.25  ? 455 TYR A CE1 1 
ATOM   3562  C CE2 . TYR A 1 455 ? 17.009  -9.077  -7.627  1.00 76.46  ? 455 TYR A CE2 1 
ATOM   3563  C CZ  . TYR A 1 455 ? 17.183  -8.642  -8.932  1.00 91.15  ? 455 TYR A CZ  1 
ATOM   3564  O OH  . TYR A 1 455 ? 18.059  -9.242  -9.791  1.00 104.22 ? 455 TYR A OH  1 
ATOM   3565  N N   . LEU A 1 456 ? 17.132  -4.736  -6.544  1.00 43.13  ? 456 LEU A N   1 
ATOM   3566  C CA  . LEU A 1 456 ? 18.570  -4.759  -6.379  1.00 44.52  ? 456 LEU A CA  1 
ATOM   3567  C C   . LEU A 1 456 ? 19.039  -3.531  -5.606  1.00 45.23  ? 456 LEU A C   1 
ATOM   3568  O O   . LEU A 1 456 ? 20.034  -3.591  -4.880  1.00 41.67  ? 456 LEU A O   1 
ATOM   3569  C CB  . LEU A 1 456 ? 19.205  -4.833  -7.762  1.00 48.64  ? 456 LEU A CB  1 
ATOM   3570  C CG  . LEU A 1 456 ? 20.648  -5.348  -7.823  1.00 58.57  ? 456 LEU A CG  1 
ATOM   3571  C CD1 . LEU A 1 456 ? 20.763  -6.794  -7.373  1.00 56.26  ? 456 LEU A CD1 1 
ATOM   3572  C CD2 . LEU A 1 456 ? 21.196  -5.226  -9.245  1.00 63.03  ? 456 LEU A CD2 1 
ATOM   3573  N N   . VAL A 1 457 ? 18.348  -2.398  -5.767  1.00 40.80  ? 457 VAL A N   1 
ATOM   3574  C CA  . VAL A 1 457 ? 18.679  -1.261  -4.927  1.00 39.65  ? 457 VAL A CA  1 
ATOM   3575  C C   . VAL A 1 457 ? 18.544  -1.701  -3.479  1.00 39.56  ? 457 VAL A C   1 
ATOM   3576  O O   . VAL A 1 457 ? 19.342  -1.316  -2.638  1.00 42.30  ? 457 VAL A O   1 
ATOM   3577  C CB  . VAL A 1 457 ? 17.859  0.009   -5.148  1.00 37.93  ? 457 VAL A CB  1 
ATOM   3578  C CG1 . VAL A 1 457 ? 18.125  1.021   -4.047  1.00 43.20  ? 457 VAL A CG1 1 
ATOM   3579  C CG2 . VAL A 1 457 ? 18.163  0.611   -6.506  1.00 40.51  ? 457 VAL A CG2 1 
ATOM   3580  N N   . ARG A 1 458 ? 17.523  -2.506  -3.213  1.00 41.85  ? 458 ARG A N   1 
ATOM   3581  C CA  . ARG A 1 458 ? 17.245  -2.928  -1.860  1.00 45.88  ? 458 ARG A CA  1 
ATOM   3582  C C   . ARG A 1 458 ? 18.424  -3.735  -1.363  1.00 47.18  ? 458 ARG A C   1 
ATOM   3583  O O   . ARG A 1 458 ? 18.997  -3.378  -0.343  1.00 56.14  ? 458 ARG A O   1 
ATOM   3584  C CB  . ARG A 1 458 ? 15.940  -3.714  -1.749  1.00 41.82  ? 458 ARG A CB  1 
ATOM   3585  C CG  . ARG A 1 458 ? 14.737  -2.839  -2.028  1.00 38.40  ? 458 ARG A CG  1 
ATOM   3586  C CD  . ARG A 1 458 ? 13.464  -3.613  -1.709  1.00 38.96  ? 458 ARG A CD  1 
ATOM   3587  N NE  . ARG A 1 458 ? 12.302  -2.722  -1.778  1.00 39.44  ? 458 ARG A NE  1 
ATOM   3588  C CZ  . ARG A 1 458 ? 11.120  -2.955  -2.303  1.00 38.67  ? 458 ARG A CZ  1 
ATOM   3589  N NH1 . ARG A 1 458 ? 10.907  -3.944  -3.139  1.00 45.00  ? 458 ARG A NH1 1 
ATOM   3590  N NH2 . ARG A 1 458 ? 10.146  -2.133  -2.016  1.00 42.15  ? 458 ARG A NH2 1 
ATOM   3591  N N   . LEU A 1 459 ? 18.804  -4.776  -2.104  1.00 48.94  ? 459 LEU A N   1 
ATOM   3592  C CA  . LEU A 1 459 ? 19.837  -5.688  -1.630  1.00 54.86  ? 459 LEU A CA  1 
ATOM   3593  C C   . LEU A 1 459 ? 21.197  -4.987  -1.580  1.00 47.85  ? 459 LEU A C   1 
ATOM   3594  O O   . LEU A 1 459 ? 21.988  -5.217  -0.681  1.00 51.97  ? 459 LEU A O   1 
ATOM   3595  C CB  . LEU A 1 459 ? 19.852  -6.986  -2.439  1.00 58.32  ? 459 LEU A CB  1 
ATOM   3596  C CG  . LEU A 1 459 ? 18.507  -7.734  -2.488  1.00 68.29  ? 459 LEU A CG  1 
ATOM   3597  C CD1 . LEU A 1 459 ? 18.652  -9.033  -3.270  1.00 76.03  ? 459 LEU A CD1 1 
ATOM   3598  C CD2 . LEU A 1 459 ? 17.853  -8.024  -1.125  1.00 67.36  ? 459 LEU A CD2 1 
ATOM   3599  N N   . LEU A 1 460 ? 21.471  -4.076  -2.499  1.00 51.57  ? 460 LEU A N   1 
ATOM   3600  C CA  . LEU A 1 460 ? 22.730  -3.346  -2.458  1.00 48.57  ? 460 LEU A CA  1 
ATOM   3601  C C   . LEU A 1 460 ? 22.774  -2.368  -1.286  1.00 46.15  ? 460 LEU A C   1 
ATOM   3602  O O   . LEU A 1 460 ? 23.846  -1.960  -0.854  1.00 48.51  ? 460 LEU A O   1 
ATOM   3603  C CB  . LEU A 1 460 ? 22.886  -2.582  -3.766  1.00 50.93  ? 460 LEU A CB  1 
ATOM   3604  C CG  . LEU A 1 460 ? 23.073  -3.427  -5.027  1.00 55.99  ? 460 LEU A CG  1 
ATOM   3605  C CD1 . LEU A 1 460 ? 23.066  -2.526  -6.249  1.00 49.89  ? 460 LEU A CD1 1 
ATOM   3606  C CD2 . LEU A 1 460 ? 24.363  -4.221  -4.921  1.00 56.03  ? 460 LEU A CD2 1 
ATOM   3607  N N   . THR A 1 461 ? 21.610  -1.926  -0.822  1.00 41.89  ? 461 THR A N   1 
ATOM   3608  C CA  . THR A 1 461 ? 21.573  -0.923  0.225   1.00 40.46  ? 461 THR A CA  1 
ATOM   3609  C C   . THR A 1 461 ? 22.188  -1.542  1.467   1.00 40.26  ? 461 THR A C   1 
ATOM   3610  O O   . THR A 1 461 ? 22.986  -0.911  2.151   1.00 44.48  ? 461 THR A O   1 
ATOM   3611  C CB  . THR A 1 461 ? 20.135  -0.452  0.452   1.00 37.54  ? 461 THR A CB  1 
ATOM   3612  O OG1 . THR A 1 461 ? 19.746  0.320   -0.681  1.00 36.32  ? 461 THR A OG1 1 
ATOM   3613  C CG2 . THR A 1 461 ? 19.981  0.431   1.671   1.00 37.45  ? 461 THR A CG2 1 
ATOM   3614  N N   . MET A 1 462 ? 21.814  -2.791  1.738   1.00 39.33  ? 462 MET A N   1 
ATOM   3615  C CA  . MET A 1 462 ? 22.197  -3.406  2.983   1.00 39.02  ? 462 MET A CA  1 
ATOM   3616  C C   . MET A 1 462 ? 23.625  -3.907  2.875   1.00 44.63  ? 462 MET A C   1 
ATOM   3617  O O   . MET A 1 462 ? 24.222  -4.223  3.884   1.00 41.94  ? 462 MET A O   1 
ATOM   3618  C CB  . MET A 1 462 ? 21.269  -4.555  3.348   1.00 43.95  ? 462 MET A CB  1 
ATOM   3619  C CG  . MET A 1 462 ? 19.810  -4.173  3.462   1.00 41.51  ? 462 MET A CG  1 
ATOM   3620  S SD  . MET A 1 462 ? 19.552  -2.611  4.316   1.00 42.31  ? 462 MET A SD  1 
ATOM   3621  C CE  . MET A 1 462 ? 20.183  -3.175  5.892   1.00 43.63  ? 462 MET A CE  1 
ATOM   3622  N N   . GLN A 1 463 ? 24.200  -3.912  1.670   1.00 48.58  ? 463 GLN A N   1 
ATOM   3623  C CA  . GLN A 1 463 ? 25.595  -4.294  1.523   1.00 48.41  ? 463 GLN A CA  1 
ATOM   3624  C C   . GLN A 1 463 ? 26.474  -3.083  1.791   1.00 44.95  ? 463 GLN A C   1 
ATOM   3625  O O   . GLN A 1 463 ? 27.653  -3.236  2.023   1.00 52.46  ? 463 GLN A O   1 
ATOM   3626  C CB  . GLN A 1 463 ? 25.934  -4.930  0.168   1.00 53.05  ? 463 GLN A CB  1 
ATOM   3627  C CG  . GLN A 1 463 ? 25.449  -6.371  -0.001  1.00 52.75  ? 463 GLN A CG  1 
ATOM   3628  C CD  . GLN A 1 463 ? 25.657  -6.943  -1.396  1.00 57.26  ? 463 GLN A CD  1 
ATOM   3629  O OE1 . GLN A 1 463 ? 26.206  -6.297  -2.293  1.00 70.37  ? 463 GLN A OE1 1 
ATOM   3630  N NE2 . GLN A 1 463 ? 25.217  -8.174  -1.612  1.00 61.87  ? 463 GLN A NE2 1 
ATOM   3631  N N   . ARG A 1 464 ? 25.924  -1.873  1.777   1.00 47.30  ? 464 ARG A N   1 
ATOM   3632  C CA  . ARG A 1 464 ? 26.756  -0.706  2.004   1.00 42.79  ? 464 ARG A CA  1 
ATOM   3633  C C   . ARG A 1 464 ? 27.245  -0.643  3.443   1.00 47.89  ? 464 ARG A C   1 
ATOM   3634  O O   . ARG A 1 464 ? 26.574  -1.102  4.355   1.00 56.72  ? 464 ARG A O   1 
ATOM   3635  C CB  . ARG A 1 464 ? 26.000  0.585   1.745   1.00 46.00  ? 464 ARG A CB  1 
ATOM   3636  C CG  . ARG A 1 464 ? 25.536  0.661   0.304   1.00 54.13  ? 464 ARG A CG  1 
ATOM   3637  C CD  . ARG A 1 464 ? 24.972  2.031   0.015   1.00 58.61  ? 464 ARG A CD  1 
ATOM   3638  N NE  . ARG A 1 464 ? 26.127  2.907   -0.172  1.00 66.85  ? 464 ARG A NE  1 
ATOM   3639  C CZ  . ARG A 1 464 ? 26.295  3.709   -1.201  1.00 62.73  ? 464 ARG A CZ  1 
ATOM   3640  N NH1 . ARG A 1 464 ? 25.384  3.794   -2.151  1.00 58.92  ? 464 ARG A NH1 1 
ATOM   3641  N NH2 . ARG A 1 464 ? 27.359  4.470   -1.234  1.00 63.97  ? 464 ARG A NH2 1 
ATOM   3642  N N   . THR A 1 465 ? 28.383  0.021   3.634   1.00 51.82  ? 465 THR A N   1 
ATOM   3643  C CA  . THR A 1 465 ? 29.089  0.034   4.904   1.00 54.75  ? 465 THR A CA  1 
ATOM   3644  C C   . THR A 1 465 ? 28.318  0.872   5.926   1.00 49.14  ? 465 THR A C   1 
ATOM   3645  O O   . THR A 1 465 ? 28.183  0.490   7.090   1.00 48.24  ? 465 THR A O   1 
ATOM   3646  C CB  . THR A 1 465 ? 30.535  0.508   4.706   1.00 58.51  ? 465 THR A CB  1 
ATOM   3647  O OG1 . THR A 1 465 ? 30.876  1.110   5.949   1.00 56.32  ? 465 THR A OG1 1 
ATOM   3648  C CG2 . THR A 1 465 ? 30.718  1.595   3.664   1.00 63.51  ? 465 THR A CG2 1 
ATOM   3649  N N   . GLU A 1 466 ? 27.780  2.005   5.481   1.00 41.54  ? 466 GLU A N   1 
ATOM   3650  C CA  . GLU A 1 466 ? 26.965  2.829   6.346   1.00 45.49  ? 466 GLU A CA  1 
ATOM   3651  C C   . GLU A 1 466 ? 25.848  2.032   7.028   1.00 44.50  ? 466 GLU A C   1 
ATOM   3652  O O   . GLU A 1 466 ? 25.352  2.475   8.046   1.00 47.74  ? 466 GLU A O   1 
ATOM   3653  C CB  . GLU A 1 466 ? 26.266  3.936   5.556   1.00 53.60  ? 466 GLU A CB  1 
ATOM   3654  C CG  . GLU A 1 466 ? 27.182  4.984   4.927   1.00 57.46  ? 466 GLU A CG  1 
ATOM   3655  C CD  . GLU A 1 466 ? 27.830  4.742   3.560   1.00 56.69  ? 466 GLU A CD  1 
ATOM   3656  O OE1 . GLU A 1 466 ? 28.002  3.581   3.112   1.00 52.62  ? 466 GLU A OE1 1 
ATOM   3657  O OE2 . GLU A 1 466 ? 28.183  5.780   2.932   1.00 57.91  ? 466 GLU A OE2 1 
ATOM   3658  N N   . TYR A 1 467 ? 25.391  0.908   6.460   1.00 42.19  ? 467 TYR A N   1 
ATOM   3659  C CA  . TYR A 1 467 ? 24.147  0.304   6.909   1.00 38.31  ? 467 TYR A CA  1 
ATOM   3660  C C   . TYR A 1 467 ? 24.370  -1.099  7.453   1.00 36.86  ? 467 TYR A C   1 
ATOM   3661  O O   . TYR A 1 467 ? 23.411  -1.843  7.642   1.00 38.15  ? 467 TYR A O   1 
ATOM   3662  C CB  . TYR A 1 467 ? 23.146  0.265   5.751   1.00 35.79  ? 467 TYR A CB  1 
ATOM   3663  C CG  . TYR A 1 467 ? 22.787  1.639   5.219   1.00 32.87  ? 467 TYR A CG  1 
ATOM   3664  C CD1 . TYR A 1 467 ? 22.535  2.685   6.076   1.00 32.31  ? 467 TYR A CD1 1 
ATOM   3665  C CD2 . TYR A 1 467 ? 22.786  1.903   3.874   1.00 32.10  ? 467 TYR A CD2 1 
ATOM   3666  C CE1 . TYR A 1 467 ? 22.253  3.944   5.616   1.00 34.86  ? 467 TYR A CE1 1 
ATOM   3667  C CE2 . TYR A 1 467 ? 22.504  3.165   3.393   1.00 32.05  ? 467 TYR A CE2 1 
ATOM   3668  C CZ  . TYR A 1 467 ? 22.209  4.186   4.262   1.00 37.17  ? 467 TYR A CZ  1 
ATOM   3669  O OH  . TYR A 1 467 ? 21.892  5.440   3.801   1.00 39.35  ? 467 TYR A OH  1 
ATOM   3670  N N   . GLN A 1 468 ? 25.614  -1.418  7.792   1.00 38.91  ? 468 GLN A N   1 
ATOM   3671  C CA  . GLN A 1 468 ? 25.928  -2.692  8.414   1.00 38.39  ? 468 GLN A CA  1 
ATOM   3672  C C   . GLN A 1 468 ? 25.501  -2.675  9.870   1.00 37.98  ? 468 GLN A C   1 
ATOM   3673  O O   . GLN A 1 468 ? 25.346  -1.625  10.483  1.00 39.31  ? 468 GLN A O   1 
ATOM   3674  C CB  . GLN A 1 468 ? 27.436  -2.961  8.404   1.00 45.00  ? 468 GLN A CB  1 
ATOM   3675  C CG  . GLN A 1 468 ? 28.000  -3.220  7.014   1.00 44.40  ? 468 GLN A CG  1 
ATOM   3676  C CD  . GLN A 1 468 ? 27.260  -4.334  6.309   1.00 48.69  ? 468 GLN A CD  1 
ATOM   3677  O OE1 . GLN A 1 468 ? 27.470  -5.527  6.562   1.00 56.87  ? 468 GLN A OE1 1 
ATOM   3678  N NE2 . GLN A 1 468 ? 26.362  -3.940  5.422   1.00 50.07  ? 468 GLN A NE2 1 
ATOM   3679  N N   . VAL A 1 469 ? 25.387  -3.863  10.448  1.00 40.19  ? 469 VAL A N   1 
ATOM   3680  C CA  . VAL A 1 469 ? 24.965  -3.964  11.824  1.00 40.07  ? 469 VAL A CA  1 
ATOM   3681  C C   . VAL A 1 469 ? 25.936  -3.246  12.756  1.00 45.25  ? 469 VAL A C   1 
ATOM   3682  O O   . VAL A 1 469 ? 25.485  -2.593  13.700  1.00 45.99  ? 469 VAL A O   1 
ATOM   3683  C CB  . VAL A 1 469 ? 24.717  -5.427  12.198  1.00 43.18  ? 469 VAL A CB  1 
ATOM   3684  C CG1 . VAL A 1 469 ? 25.745  -6.354  11.624  1.00 56.85  ? 469 VAL A CG1 1 
ATOM   3685  C CG2 . VAL A 1 469 ? 24.609  -5.583  13.697  1.00 47.57  ? 469 VAL A CG2 1 
ATOM   3686  N N   . ASP A 1 470 ? 27.249  -3.292  12.476  1.00 49.20  ? 470 ASP A N   1 
ATOM   3687  C CA  . ASP A 1 470 ? 28.230  -2.588  13.298  1.00 44.18  ? 470 ASP A CA  1 
ATOM   3688  C C   . ASP A 1 470 ? 28.558  -1.192  12.785  1.00 44.68  ? 470 ASP A C   1 
ATOM   3689  O O   . ASP A 1 470 ? 29.490  -0.560  13.266  1.00 50.84  ? 470 ASP A O   1 
ATOM   3690  C CB  . ASP A 1 470 ? 29.519  -3.367  13.423  1.00 47.59  ? 470 ASP A CB  1 
ATOM   3691  C CG  . ASP A 1 470 ? 29.435  -4.434  14.489  1.00 55.98  ? 470 ASP A CG  1 
ATOM   3692  O OD1 . ASP A 1 470 ? 29.043  -4.061  15.624  1.00 67.94  ? 470 ASP A OD1 1 
ATOM   3693  O OD2 . ASP A 1 470 ? 29.752  -5.606  14.167  1.00 64.08  ? 470 ASP A OD2 1 
ATOM   3694  N N   . GLY A 1 471 ? 27.805  -0.709  11.803  1.00 41.52  ? 471 GLY A N   1 
ATOM   3695  C CA  . GLY A 1 471 ? 28.055  0.597   11.230  1.00 39.16  ? 471 GLY A CA  1 
ATOM   3696  C C   . GLY A 1 471 ? 27.369  1.675   12.056  1.00 38.65  ? 471 GLY A C   1 
ATOM   3697  O O   . GLY A 1 471 ? 26.731  1.399   13.063  1.00 41.15  ? 471 GLY A O   1 
ATOM   3698  N N   . PRO A 1 472 ? 27.469  2.938   11.632  1.00 37.41  ? 472 PRO A N   1 
ATOM   3699  C CA  . PRO A 1 472 ? 26.967  4.051   12.428  1.00 42.06  ? 472 PRO A CA  1 
ATOM   3700  C C   . PRO A 1 472 ? 25.451  4.211   12.487  1.00 45.50  ? 472 PRO A C   1 
ATOM   3701  O O   . PRO A 1 472 ? 24.943  4.954   13.314  1.00 42.97  ? 472 PRO A O   1 
ATOM   3702  C CB  . PRO A 1 472 ? 27.662  5.276   11.798  1.00 43.31  ? 472 PRO A CB  1 
ATOM   3703  C CG  . PRO A 1 472 ? 27.960  4.870   10.385  1.00 45.46  ? 472 PRO A CG  1 
ATOM   3704  C CD  . PRO A 1 472 ? 28.145  3.350   10.398  1.00 42.61  ? 472 PRO A CD  1 
ATOM   3705  N N   . LEU A 1 473 ? 24.698  3.485   11.667  1.00 46.97  ? 473 LEU A N   1 
ATOM   3706  C CA  . LEU A 1 473 ? 23.265  3.669   11.716  1.00 43.83  ? 473 LEU A CA  1 
ATOM   3707  C C   . LEU A 1 473 ? 22.692  2.954   12.930  1.00 42.46  ? 473 LEU A C   1 
ATOM   3708  O O   . LEU A 1 473 ? 21.504  3.031   13.190  1.00 46.66  ? 473 LEU A O   1 
ATOM   3709  C CB  . LEU A 1 473 ? 22.645  3.135   10.440  1.00 46.57  ? 473 LEU A CB  1 
ATOM   3710  C CG  . LEU A 1 473 ? 21.156  3.436   10.293  1.00 50.63  ? 473 LEU A CG  1 
ATOM   3711  C CD1 . LEU A 1 473 ? 20.892  4.877   9.970   1.00 47.55  ? 473 LEU A CD1 1 
ATOM   3712  C CD2 . LEU A 1 473 ? 20.579  2.545   9.222   1.00 65.42  ? 473 LEU A CD2 1 
ATOM   3713  N N   . THR A 1 474 ? 23.542  2.236   13.648  1.00 38.78  ? 474 THR A N   1 
ATOM   3714  C CA  . THR A 1 474 ? 23.120  1.429   14.777  1.00 40.73  ? 474 THR A CA  1 
ATOM   3715  C C   . THR A 1 474 ? 23.579  2.059   16.091  1.00 38.05  ? 474 THR A C   1 
ATOM   3716  O O   . THR A 1 474 ? 23.262  1.566   17.161  1.00 45.57  ? 474 THR A O   1 
ATOM   3717  C CB  . THR A 1 474 ? 23.743  0.072   14.496  1.00 39.99  ? 474 THR A CB  1 
ATOM   3718  O OG1 . THR A 1 474 ? 22.711  -0.886  14.575  1.00 48.05  ? 474 THR A OG1 1 
ATOM   3719  C CG2 . THR A 1 474 ? 24.919  -0.245  15.379  1.00 45.69  ? 474 THR A CG2 1 
ATOM   3720  N N   . ASP A 1 475 ? 24.325  3.165   15.998  1.00 38.07  ? 475 ASP A N   1 
ATOM   3721  C CA  . ASP A 1 475 ? 24.927  3.822   17.144  1.00 40.91  ? 475 ASP A CA  1 
ATOM   3722  C C   . ASP A 1 475 ? 23.847  4.289   18.101  1.00 39.99  ? 475 ASP A C   1 
ATOM   3723  O O   . ASP A 1 475 ? 23.968  4.078   19.300  1.00 43.45  ? 475 ASP A O   1 
ATOM   3724  C CB  . ASP A 1 475 ? 25.777  5.017   16.747  1.00 41.65  ? 475 ASP A CB  1 
ATOM   3725  C CG  . ASP A 1 475 ? 27.108  4.676   16.097  1.00 47.21  ? 475 ASP A CG  1 
ATOM   3726  O OD1 . ASP A 1 475 ? 27.618  3.557   16.329  1.00 46.90  ? 475 ASP A OD1 1 
ATOM   3727  O OD2 . ASP A 1 475 ? 27.603  5.518   15.326  1.00 52.94  ? 475 ASP A OD2 1 
ATOM   3728  N N   . LEU A 1 476 ? 22.803  4.929   17.572  1.00 39.61  ? 476 LEU A N   1 
ATOM   3729  C CA  . LEU A 1 476 ? 21.779  5.481   18.440  1.00 35.68  ? 476 LEU A CA  1 
ATOM   3730  C C   . LEU A 1 476 ? 21.091  4.338   19.159  1.00 31.87  ? 476 LEU A C   1 
ATOM   3731  O O   . LEU A 1 476 ? 20.910  4.352   20.370  1.00 36.46  ? 476 LEU A O   1 
ATOM   3732  C CB  . LEU A 1 476 ? 20.783  6.345   17.687  1.00 38.32  ? 476 LEU A CB  1 
ATOM   3733  C CG  . LEU A 1 476 ? 19.657  6.907   18.555  1.00 40.06  ? 476 LEU A CG  1 
ATOM   3734  C CD1 . LEU A 1 476 ? 20.228  7.772   19.665  1.00 36.85  ? 476 LEU A CD1 1 
ATOM   3735  C CD2 . LEU A 1 476 ? 18.697  7.672   17.673  1.00 36.56  ? 476 LEU A CD2 1 
ATOM   3736  N N   . ALA A 1 477 ? 20.793  3.290   18.418  1.00 34.55  ? 477 ALA A N   1 
ATOM   3737  C CA  . ALA A 1 477 ? 20.131  2.166   19.041  1.00 35.18  ? 477 ALA A CA  1 
ATOM   3738  C C   . ALA A 1 477 ? 21.025  1.546   20.106  1.00 34.62  ? 477 ALA A C   1 
ATOM   3739  O O   . ALA A 1 477 ? 20.557  1.199   21.178  1.00 35.00  ? 477 ALA A O   1 
ATOM   3740  C CB  . ALA A 1 477 ? 19.719  1.177   17.993  1.00 37.67  ? 477 ALA A CB  1 
ATOM   3741  N N   . ARG A 1 478 ? 22.323  1.415   19.836  1.00 40.54  ? 478 ARG A N   1 
ATOM   3742  C CA  . ARG A 1 478 ? 23.182  0.740   20.792  1.00 36.83  ? 478 ARG A CA  1 
ATOM   3743  C C   . ARG A 1 478 ? 23.270  1.546   22.069  1.00 33.23  ? 478 ARG A C   1 
ATOM   3744  O O   . ARG A 1 478 ? 23.323  1.005   23.161  1.00 37.05  ? 478 ARG A O   1 
ATOM   3745  C CB  . ARG A 1 478 ? 24.602  0.563   20.264  1.00 39.50  ? 478 ARG A CB  1 
ATOM   3746  C CG  . ARG A 1 478 ? 24.734  -0.564  19.261  1.00 40.14  ? 478 ARG A CG  1 
ATOM   3747  C CD  . ARG A 1 478 ? 26.144  -0.560  18.716  1.00 41.68  ? 478 ARG A CD  1 
ATOM   3748  N NE  . ARG A 1 478 ? 26.247  -1.436  17.554  1.00 42.58  ? 478 ARG A NE  1 
ATOM   3749  C CZ  . ARG A 1 478 ? 26.141  -2.777  17.505  1.00 49.20  ? 478 ARG A CZ  1 
ATOM   3750  N NH1 . ARG A 1 478 ? 26.260  -3.535  18.589  1.00 44.68  ? 478 ARG A NH1 1 
ATOM   3751  N NH2 . ARG A 1 478 ? 25.994  -3.362  16.327  1.00 45.72  ? 478 ARG A NH2 1 
ATOM   3752  N N   . GLN A 1 479 ? 23.340  2.850   21.908  1.00 35.95  ? 479 GLN A N   1 
ATOM   3753  C CA  . GLN A 1 479 ? 23.446  3.750   23.041  1.00 40.27  ? 479 GLN A CA  1 
ATOM   3754  C C   . GLN A 1 479 ? 22.195  3.647   23.912  1.00 45.22  ? 479 GLN A C   1 
ATOM   3755  O O   . GLN A 1 479 ? 22.289  3.612   25.126  1.00 52.82  ? 479 GLN A O   1 
ATOM   3756  C CB  . GLN A 1 479 ? 23.712  5.113   22.404  1.00 43.40  ? 479 GLN A CB  1 
ATOM   3757  C CG  . GLN A 1 479 ? 23.771  6.282   23.372  1.00 58.03  ? 479 GLN A CG  1 
ATOM   3758  C CD  . GLN A 1 479 ? 24.055  7.575   22.640  1.00 68.18  ? 479 GLN A CD  1 
ATOM   3759  O OE1 . GLN A 1 479 ? 25.052  7.697   21.916  1.00 74.57  ? 479 GLN A OE1 1 
ATOM   3760  N NE2 . GLN A 1 479 ? 23.144  8.527   22.764  1.00 67.92  ? 479 GLN A NE2 1 
ATOM   3761  N N   . VAL A 1 480 ? 21.017  3.584   23.296  1.00 42.32  ? 480 VAL A N   1 
ATOM   3762  C CA  . VAL A 1 480 ? 19.785  3.420   24.040  1.00 37.21  ? 480 VAL A CA  1 
ATOM   3763  C C   . VAL A 1 480 ? 19.774  2.089   24.785  1.00 38.91  ? 480 VAL A C   1 
ATOM   3764  O O   . VAL A 1 480 ? 19.257  1.994   25.890  1.00 41.24  ? 480 VAL A O   1 
ATOM   3765  C CB  . VAL A 1 480 ? 18.661  3.522   22.995  1.00 43.35  ? 480 VAL A CB  1 
ATOM   3766  C CG1 . VAL A 1 480 ? 17.420  2.732   23.345  1.00 40.05  ? 480 VAL A CG1 1 
ATOM   3767  C CG2 . VAL A 1 480 ? 18.317  4.975   22.681  1.00 48.05  ? 480 VAL A CG2 1 
ATOM   3768  N N   . LEU A 1 481 ? 20.324  1.034   24.190  1.00 38.62  ? 481 LEU A N   1 
ATOM   3769  C CA  . LEU A 1 481 ? 20.298  -0.272  24.827  1.00 38.18  ? 481 LEU A CA  1 
ATOM   3770  C C   . LEU A 1 481 ? 21.471  -0.450  25.786  1.00 40.56  ? 481 LEU A C   1 
ATOM   3771  O O   . LEU A 1 481 ? 21.480  -1.419  26.533  1.00 41.34  ? 481 LEU A O   1 
ATOM   3772  C CB  . LEU A 1 481 ? 20.362  -1.350  23.753  1.00 38.00  ? 481 LEU A CB  1 
ATOM   3773  C CG  . LEU A 1 481 ? 19.113  -1.514  22.897  1.00 41.17  ? 481 LEU A CG  1 
ATOM   3774  C CD1 . LEU A 1 481 ? 19.378  -2.178  21.562  1.00 40.80  ? 481 LEU A CD1 1 
ATOM   3775  C CD2 . LEU A 1 481 ? 18.128  -2.323  23.695  1.00 40.38  ? 481 LEU A CD2 1 
ATOM   3776  N N   . GLY A 1 482 ? 22.471  0.432   25.742  1.00 37.33  ? 482 GLY A N   1 
ATOM   3777  C CA  . GLY A 1 482 ? 23.658  0.246   26.559  1.00 39.63  ? 482 GLY A CA  1 
ATOM   3778  C C   . GLY A 1 482 ? 24.491  -0.931  26.045  1.00 45.15  ? 482 GLY A C   1 
ATOM   3779  O O   . GLY A 1 482 ? 24.871  -1.803  26.796  1.00 44.23  ? 482 GLY A O   1 
ATOM   3780  N N   . PHE A 1 483 ? 24.763  -0.974  24.740  1.00 54.15  ? 483 PHE A N   1 
ATOM   3781  C CA  . PHE A 1 483 ? 25.464  -2.102  24.152  1.00 54.67  ? 483 PHE A CA  1 
ATOM   3782  C C   . PHE A 1 483 ? 26.777  -1.622  23.547  1.00 57.79  ? 483 PHE A C   1 
ATOM   3783  O O   . PHE A 1 483 ? 26.830  -0.564  22.918  1.00 54.74  ? 483 PHE A O   1 
ATOM   3784  C CB  . PHE A 1 483 ? 24.753  -2.786  22.974  1.00 55.27  ? 483 PHE A CB  1 
ATOM   3785  C CG  . PHE A 1 483 ? 23.557  -3.698  23.231  1.00 47.63  ? 483 PHE A CG  1 
ATOM   3786  C CD1 . PHE A 1 483 ? 23.206  -4.110  24.511  1.00 45.61  ? 483 PHE A CD1 1 
ATOM   3787  C CD2 . PHE A 1 483 ? 22.803  -4.168  22.165  1.00 43.08  ? 483 PHE A CD2 1 
ATOM   3788  C CE1 . PHE A 1 483 ? 22.105  -4.915  24.706  1.00 41.31  ? 483 PHE A CE1 1 
ATOM   3789  C CE2 . PHE A 1 483 ? 21.725  -5.006  22.371  1.00 40.59  ? 483 PHE A CE2 1 
ATOM   3790  C CZ  . PHE A 1 483 ? 21.373  -5.361  23.639  1.00 40.17  ? 483 PHE A CZ  1 
ATOM   3791  N N   . GLY A 1 484 ? 27.815  -2.451  23.677  1.00 52.16  ? 484 GLY A N   1 
ATOM   3792  C CA  . GLY A 1 484 ? 28.979  -2.291  22.827  1.00 52.27  ? 484 GLY A CA  1 
ATOM   3793  C C   . GLY A 1 484 ? 28.633  -2.694  21.398  1.00 54.26  ? 484 GLY A C   1 
ATOM   3794  O O   . GLY A 1 484 ? 27.471  -2.632  21.009  1.00 66.83  ? 484 GLY A O   1 
ATOM   3795  N N   . ASP A 1 485 ? 29.655  -3.095  20.633  1.00 57.24  ? 485 ASP A N   1 
ATOM   3796  C CA  . ASP A 1 485 ? 29.526  -3.592  19.265  1.00 56.54  ? 485 ASP A CA  1 
ATOM   3797  C C   . ASP A 1 485 ? 29.250  -5.100  19.301  1.00 51.01  ? 485 ASP A C   1 
ATOM   3798  O O   . ASP A 1 485 ? 29.217  -5.683  20.383  1.00 45.83  ? 485 ASP A O   1 
ATOM   3799  C CB  . ASP A 1 485 ? 30.769  -3.227  18.453  1.00 62.58  ? 485 ASP A CB  1 
ATOM   3800  C CG  . ASP A 1 485 ? 32.079  -3.895  18.871  1.00 64.11  ? 485 ASP A CG  1 
ATOM   3801  O OD1 . ASP A 1 485 ? 32.310  -4.071  20.092  1.00 72.02  ? 485 ASP A OD1 1 
ATOM   3802  O OD2 . ASP A 1 485 ? 32.861  -4.240  17.970  1.00 69.34  ? 485 ASP A OD2 1 
ATOM   3803  N N   . THR A 1 486 ? 29.051  -5.714  18.113  1.00 53.97  ? 486 THR A N   1 
ATOM   3804  C CA  . THR A 1 486 ? 28.827  -7.150  17.947  1.00 54.74  ? 486 THR A CA  1 
ATOM   3805  C C   . THR A 1 486 ? 29.764  -7.973  18.831  1.00 62.38  ? 486 THR A C   1 
ATOM   3806  O O   . THR A 1 486 ? 29.358  -8.936  19.475  1.00 71.77  ? 486 THR A O   1 
ATOM   3807  C CB  . THR A 1 486 ? 29.054  -7.499  16.480  1.00 59.57  ? 486 THR A CB  1 
ATOM   3808  O OG1 . THR A 1 486 ? 28.072  -6.728  15.806  1.00 65.35  ? 486 THR A OG1 1 
ATOM   3809  C CG2 . THR A 1 486 ? 28.870  -8.976  16.169  1.00 66.35  ? 486 THR A CG2 1 
ATOM   3810  N N   . GLU A 1 487 ? 31.033  -7.569  18.822  1.00 69.62  ? 487 GLU A N   1 
ATOM   3811  C CA  . GLU A 1 487 ? 32.130  -8.260  19.469  1.00 71.92  ? 487 GLU A CA  1 
ATOM   3812  C C   . GLU A 1 487 ? 31.938  -8.177  20.984  1.00 58.42  ? 487 GLU A C   1 
ATOM   3813  O O   . GLU A 1 487 ? 32.093  -9.156  21.702  1.00 63.92  ? 487 GLU A O   1 
ATOM   3814  C CB  . GLU A 1 487 ? 33.374  -7.564  18.893  1.00 86.83  ? 487 GLU A CB  1 
ATOM   3815  C CG  . GLU A 1 487 ? 34.625  -8.428  18.797  1.00 95.41  ? 487 GLU A CG  1 
ATOM   3816  C CD  . GLU A 1 487 ? 34.972  -9.050  20.131  1.00 111.77 ? 487 GLU A CD  1 
ATOM   3817  O OE1 . GLU A 1 487 ? 35.124  -8.290  21.118  1.00 116.82 ? 487 GLU A OE1 1 
ATOM   3818  O OE2 . GLU A 1 487 ? 35.059  -10.298 20.178  1.00 120.13 ? 487 GLU A OE2 1 
ATOM   3819  N N   . ALA A 1 488 ? 31.610  -6.986  21.470  1.00 59.18  ? 488 ALA A N   1 
ATOM   3820  C CA  . ALA A 1 488 ? 31.432  -6.773  22.893  1.00 62.50  ? 488 ALA A CA  1 
ATOM   3821  C C   . ALA A 1 488 ? 30.282  -7.633  23.399  1.00 61.58  ? 488 ALA A C   1 
ATOM   3822  O O   . ALA A 1 488 ? 30.408  -8.253  24.443  1.00 65.01  ? 488 ALA A O   1 
ATOM   3823  C CB  . ALA A 1 488 ? 31.177  -5.305  23.163  1.00 67.25  ? 488 ALA A CB  1 
ATOM   3824  N N   . LEU A 1 489 ? 29.168  -7.652  22.647  1.00 60.63  ? 489 LEU A N   1 
ATOM   3825  C CA  . LEU A 1 489 ? 27.972  -8.397  23.023  1.00 57.23  ? 489 LEU A CA  1 
ATOM   3826  C C   . LEU A 1 489 ? 28.225  -9.899  23.003  1.00 52.93  ? 489 LEU A C   1 
ATOM   3827  O O   . LEU A 1 489 ? 27.722  -10.605 23.868  1.00 49.82  ? 489 LEU A O   1 
ATOM   3828  C CB  . LEU A 1 489 ? 26.833  -8.079  22.059  1.00 58.79  ? 489 LEU A CB  1 
ATOM   3829  C CG  . LEU A 1 489 ? 26.128  -6.745  22.276  1.00 59.68  ? 489 LEU A CG  1 
ATOM   3830  C CD1 . LEU A 1 489 ? 25.321  -6.358  21.055  1.00 59.32  ? 489 LEU A CD1 1 
ATOM   3831  C CD2 . LEU A 1 489 ? 25.255  -6.902  23.498  1.00 63.09  ? 489 LEU A CD2 1 
ATOM   3832  N N   . ALA A 1 490 ? 28.916  -10.375 21.955  1.00 51.57  ? 490 ALA A N   1 
ATOM   3833  C CA  . ALA A 1 490 ? 29.237  -11.784 21.799  1.00 56.55  ? 490 ALA A CA  1 
ATOM   3834  C C   . ALA A 1 490 ? 30.131  -12.242 22.947  1.00 61.32  ? 490 ALA A C   1 
ATOM   3835  O O   . ALA A 1 490 ? 29.990  -13.365 23.443  1.00 59.22  ? 490 ALA A O   1 
ATOM   3836  C CB  . ALA A 1 490 ? 29.876  -12.035 20.443  1.00 56.67  ? 490 ALA A CB  1 
ATOM   3837  N N   . ALA A 1 491 ? 31.023  -11.342 23.373  1.00 61.85  ? 491 ALA A N   1 
ATOM   3838  C CA  . ALA A 1 491 ? 31.879  -11.589 24.518  1.00 64.27  ? 491 ALA A CA  1 
ATOM   3839  C C   . ALA A 1 491 ? 31.058  -11.820 25.783  1.00 59.41  ? 491 ALA A C   1 
ATOM   3840  O O   . ALA A 1 491 ? 31.318  -12.776 26.499  1.00 68.65  ? 491 ALA A O   1 
ATOM   3841  C CB  . ALA A 1 491 ? 32.848  -10.438 24.690  1.00 73.97  ? 491 ALA A CB  1 
ATOM   3842  N N   . ARG A 1 492 ? 30.081  -10.952 26.085  1.00 60.52  ? 492 ARG A N   1 
ATOM   3843  C CA  . ARG A 1 492 ? 29.300  -11.125 27.302  1.00 54.79  ? 492 ARG A CA  1 
ATOM   3844  C C   . ARG A 1 492 ? 28.573  -12.470 27.261  1.00 56.17  ? 492 ARG A C   1 
ATOM   3845  O O   . ARG A 1 492 ? 28.552  -13.207 28.241  1.00 58.17  ? 492 ARG A O   1 
ATOM   3846  C CB  . ARG A 1 492 ? 28.284  -10.005 27.555  1.00 62.23  ? 492 ARG A CB  1 
ATOM   3847  C CG  . ARG A 1 492 ? 27.308  -10.353 28.684  1.00 67.15  ? 492 ARG A CG  1 
ATOM   3848  C CD  . ARG A 1 492 ? 26.178  -9.358  28.963  1.00 62.08  ? 492 ARG A CD  1 
ATOM   3849  N NE  . ARG A 1 492 ? 26.748  -8.032  29.206  1.00 64.00  ? 492 ARG A NE  1 
ATOM   3850  C CZ  . ARG A 1 492 ? 26.876  -7.092  28.284  1.00 63.15  ? 492 ARG A CZ  1 
ATOM   3851  N NH1 . ARG A 1 492 ? 26.084  -7.060  27.234  1.00 66.58  ? 492 ARG A NH1 1 
ATOM   3852  N NH2 . ARG A 1 492 ? 27.765  -6.138  28.454  1.00 65.59  ? 492 ARG A NH2 1 
ATOM   3853  N N   . ALA A 1 493 ? 27.955  -12.778 26.118  1.00 56.37  ? 493 ALA A N   1 
ATOM   3854  C CA  . ALA A 1 493 ? 27.207  -14.010 25.958  1.00 52.17  ? 493 ALA A CA  1 
ATOM   3855  C C   . ALA A 1 493 ? 28.097  -15.209 26.274  1.00 53.98  ? 493 ALA A C   1 
ATOM   3856  O O   . ALA A 1 493 ? 27.691  -16.113 27.005  1.00 46.68  ? 493 ALA A O   1 
ATOM   3857  C CB  . ALA A 1 493 ? 26.674  -14.096 24.548  1.00 54.58  ? 493 ALA A CB  1 
ATOM   3858  N N   . ALA A 1 494 ? 29.293  -15.223 25.672  1.00 52.79  ? 494 ALA A N   1 
ATOM   3859  C CA  . ALA A 1 494 ? 30.184  -16.365 25.796  1.00 58.54  ? 494 ALA A CA  1 
ATOM   3860  C C   . ALA A 1 494 ? 30.572  -16.520 27.257  1.00 62.88  ? 494 ALA A C   1 
ATOM   3861  O O   . ALA A 1 494 ? 30.566  -17.631 27.785  1.00 61.40  ? 494 ALA A O   1 
ATOM   3862  C CB  . ALA A 1 494 ? 31.403  -16.205 24.917  1.00 60.76  ? 494 ALA A CB  1 
ATOM   3863  N N   . GLU A 1 495 ? 30.847  -15.387 27.911  1.00 60.96  ? 495 GLU A N   1 
ATOM   3864  C CA  . GLU A 1 495 ? 31.206  -15.424 29.314  1.00 64.79  ? 495 GLU A CA  1 
ATOM   3865  C C   . GLU A 1 495 ? 30.046  -15.949 30.151  1.00 62.82  ? 495 GLU A C   1 
ATOM   3866  O O   . GLU A 1 495 ? 30.270  -16.709 31.084  1.00 74.58  ? 495 GLU A O   1 
ATOM   3867  C CB  . GLU A 1 495 ? 31.739  -14.072 29.775  1.00 68.90  ? 495 GLU A CB  1 
ATOM   3868  C CG  . GLU A 1 495 ? 33.049  -13.694 29.081  1.00 72.93  ? 495 GLU A CG  1 
ATOM   3869  C CD  . GLU A 1 495 ? 34.151  -14.746 28.999  1.00 69.17  ? 495 GLU A CD  1 
ATOM   3870  O OE1 . GLU A 1 495 ? 34.312  -15.520 29.963  1.00 67.76  ? 495 GLU A OE1 1 
ATOM   3871  O OE2 . GLU A 1 495 ? 34.884  -14.756 27.985  1.00 60.78  ? 495 GLU A OE2 1 
ATOM   3872  N N   . VAL A 1 496 ? 28.807  -15.576 29.822  1.00 71.87  ? 496 VAL A N   1 
ATOM   3873  C CA  . VAL A 1 496 ? 27.661  -16.057 30.587  1.00 66.80  ? 496 VAL A CA  1 
ATOM   3874  C C   . VAL A 1 496 ? 27.529  -17.575 30.423  1.00 63.85  ? 496 VAL A C   1 
ATOM   3875  O O   . VAL A 1 496 ? 27.092  -18.247 31.342  1.00 69.78  ? 496 VAL A O   1 
ATOM   3876  C CB  . VAL A 1 496 ? 26.377  -15.301 30.187  1.00 68.84  ? 496 VAL A CB  1 
ATOM   3877  C CG1 . VAL A 1 496 ? 25.110  -16.007 30.667  1.00 71.38  ? 496 VAL A CG1 1 
ATOM   3878  C CG2 . VAL A 1 496 ? 26.398  -13.856 30.671  1.00 61.73  ? 496 VAL A CG2 1 
ATOM   3879  N N   . GLU A 1 497 ? 27.907  -18.112 29.252  1.00 68.26  ? 497 GLU A N   1 
ATOM   3880  C CA  . GLU A 1 497 ? 27.941  -19.550 29.009  1.00 72.03  ? 497 GLU A CA  1 
ATOM   3881  C C   . GLU A 1 497 ? 29.017  -20.203 29.875  1.00 71.69  ? 497 GLU A C   1 
ATOM   3882  O O   . GLU A 1 497 ? 28.751  -21.215 30.521  1.00 64.10  ? 497 GLU A O   1 
ATOM   3883  C CB  . GLU A 1 497 ? 28.209  -19.936 27.549  1.00 71.13  ? 497 GLU A CB  1 
ATOM   3884  C CG  . GLU A 1 497 ? 26.956  -20.030 26.681  1.00 73.91  ? 497 GLU A CG  1 
ATOM   3885  C CD  . GLU A 1 497 ? 27.183  -20.114 25.180  1.00 76.42  ? 497 GLU A CD  1 
ATOM   3886  O OE1 . GLU A 1 497 ? 28.024  -20.957 24.812  1.00 77.01  ? 497 GLU A OE1 1 
ATOM   3887  O OE2 . GLU A 1 497 ? 26.532  -19.379 24.389  1.00 66.49  ? 497 GLU A OE2 1 
ATOM   3888  N N   . LYS A 1 498 ? 30.220  -19.613 29.887  1.00 73.84  ? 498 LYS A N   1 
ATOM   3889  C CA  . LYS A 1 498 ? 31.354  -20.182 30.606  1.00 81.86  ? 498 LYS A CA  1 
ATOM   3890  C C   . LYS A 1 498 ? 31.165  -20.089 32.124  1.00 82.38  ? 498 LYS A C   1 
ATOM   3891  O O   . LYS A 1 498 ? 31.758  -20.879 32.848  1.00 83.99  ? 498 LYS A O   1 
ATOM   3892  C CB  . LYS A 1 498 ? 32.684  -19.551 30.166  1.00 84.13  ? 498 LYS A CB  1 
ATOM   3893  C CG  . LYS A 1 498 ? 33.176  -19.988 28.783  1.00 94.27  ? 498 LYS A CG  1 
ATOM   3894  C CD  . LYS A 1 498 ? 34.194  -19.053 28.129  1.00 98.86  ? 498 LYS A CD  1 
ATOM   3895  C CE  . LYS A 1 498 ? 34.618  -19.528 26.768  1.00 101.79 ? 498 LYS A CE  1 
ATOM   3896  N NZ  . LYS A 1 498 ? 35.432  -18.537 26.063  1.00 102.04 ? 498 LYS A NZ  1 
ATOM   3897  N N   . ASN A 1 499 ? 30.334  -19.155 32.613  1.00 88.57  ? 499 ASN A N   1 
ATOM   3898  C CA  . ASN A 1 499 ? 30.146  -18.968 34.049  1.00 89.92  ? 499 ASN A CA  1 
ATOM   3899  C C   . ASN A 1 499 ? 28.901  -19.716 34.538  1.00 88.87  ? 499 ASN A C   1 
ATOM   3900  O O   . ASN A 1 499 ? 28.351  -19.366 35.579  1.00 93.79  ? 499 ASN A O   1 
ATOM   3901  C CB  . ASN A 1 499 ? 30.098  -17.483 34.425  1.00 91.99  ? 499 ASN A CB  1 
ATOM   3902  C CG  . ASN A 1 499 ? 31.468  -16.844 34.529  1.00 94.15  ? 499 ASN A CG  1 
ATOM   3903  O OD1 . ASN A 1 499 ? 32.274  -17.221 35.388  1.00 106.08 ? 499 ASN A OD1 1 
ATOM   3904  N ND2 . ASN A 1 499 ? 31.759  -15.867 33.684  1.00 91.78  ? 499 ASN A ND2 1 
ATOM   3905  N N   . SER A 1 500 ? 28.445  -20.731 33.790  1.00 83.46  ? 500 SER A N   1 
ATOM   3906  C CA  . SER A 1 500 ? 27.293  -21.537 34.179  1.00 91.16  ? 500 SER A CA  1 
ATOM   3907  C C   . SER A 1 500 ? 27.535  -22.978 33.738  1.00 97.67  ? 500 SER A C   1 
ATOM   3908  O O   . SER A 1 500 ? 28.591  -23.263 33.172  1.00 105.34 ? 500 SER A O   1 
ATOM   3909  C CB  . SER A 1 500 ? 26.022  -20.980 33.585  1.00 92.61  ? 500 SER A CB  1 
ATOM   3910  O OG  . SER A 1 500 ? 26.165  -20.815 32.182  1.00 96.50  ? 500 SER A OG  1 
ATOM   3911  N N   . ASN A 1 501 ? 26.579  -23.887 33.995  1.00 100.88 ? 501 ASN A N   1 
ATOM   3912  C CA  . ASN A 1 501 ? 26.662  -25.232 33.428  1.00 115.28 ? 501 ASN A CA  1 
ATOM   3913  C C   . ASN A 1 501 ? 25.287  -25.702 32.959  1.00 108.87 ? 501 ASN A C   1 
ATOM   3914  O O   . ASN A 1 501 ? 24.329  -25.713 33.729  1.00 106.96 ? 501 ASN A O   1 
ATOM   3915  C CB  . ASN A 1 501 ? 27.378  -26.227 34.343  1.00 118.65 ? 501 ASN A CB  1 
ATOM   3916  C CG  . ASN A 1 501 ? 28.818  -26.476 33.932  1.00 118.70 ? 501 ASN A CG  1 
ATOM   3917  O OD1 . ASN A 1 501 ? 29.247  -26.111 32.828  1.00 113.83 ? 501 ASN A OD1 1 
ATOM   3918  N ND2 . ASN A 1 501 ? 29.583  -27.120 34.800  1.00 110.99 ? 501 ASN A ND2 1 
ATOM   3919  N N   . TRP A 1 502 ? 25.257  -26.147 31.691  1.00 108.86 ? 502 TRP A N   1 
ATOM   3920  C CA  . TRP A 1 502 ? 24.064  -26.197 30.860  1.00 99.27  ? 502 TRP A CA  1 
ATOM   3921  C C   . TRP A 1 502 ? 24.088  -27.458 29.966  1.00 92.05  ? 502 TRP A C   1 
ATOM   3922  O O   . TRP A 1 502 ? 23.366  -28.430 30.280  1.00 85.67  ? 502 TRP A O   1 
ATOM   3923  C CB  . TRP A 1 502 ? 23.994  -24.921 29.998  1.00 98.82  ? 502 TRP A CB  1 
ATOM   3924  C CG  . TRP A 1 502 ? 23.593  -23.635 30.686  1.00 92.73  ? 502 TRP A CG  1 
ATOM   3925  C CD1 . TRP A 1 502 ? 22.977  -23.467 31.895  1.00 94.30  ? 502 TRP A CD1 1 
ATOM   3926  C CD2 . TRP A 1 502 ? 23.720  -22.305 30.126  1.00 87.33  ? 502 TRP A CD2 1 
ATOM   3927  N NE1 . TRP A 1 502 ? 22.746  -22.137 32.141  1.00 85.44  ? 502 TRP A NE1 1 
ATOM   3928  C CE2 . TRP A 1 502 ? 23.180  -21.400 31.071  1.00 79.46  ? 502 TRP A CE2 1 
ATOM   3929  C CE3 . TRP A 1 502 ? 24.235  -21.795 28.924  1.00 80.11  ? 502 TRP A CE3 1 
ATOM   3930  C CZ2 . TRP A 1 502 ? 23.149  -20.024 30.850  1.00 81.28  ? 502 TRP A CZ2 1 
ATOM   3931  C CZ3 . TRP A 1 502 ? 24.195  -20.434 28.708  1.00 77.57  ? 502 TRP A CZ3 1 
ATOM   3932  C CH2 . TRP A 1 502 ? 23.656  -19.562 29.656  1.00 79.70  ? 502 TRP A CH2 1 
ATOM   3933  N N   . MET B 1 1   ? 21.133  42.872  -47.038 1.00 48.30  ? 1   MET B N   1 
ATOM   3934  C CA  . MET B 1 1   ? 20.830  44.320  -46.875 1.00 57.09  ? 1   MET B CA  1 
ATOM   3935  C C   . MET B 1 1   ? 20.635  44.919  -48.262 1.00 58.00  ? 1   MET B C   1 
ATOM   3936  O O   . MET B 1 1   ? 21.517  44.785  -49.103 1.00 60.64  ? 1   MET B O   1 
ATOM   3937  C CB  . MET B 1 1   ? 21.970  45.089  -46.197 1.00 53.97  ? 1   MET B CB  1 
ATOM   3938  C CG  . MET B 1 1   ? 22.359  44.591  -44.819 1.00 56.15  ? 1   MET B CG  1 
ATOM   3939  S SD  . MET B 1 1   ? 23.903  45.317  -44.216 1.00 66.91  ? 1   MET B SD  1 
ATOM   3940  C CE  . MET B 1 1   ? 23.360  47.028  -44.108 1.00 71.20  ? 1   MET B CE  1 
ATOM   3941  N N   . ARG B 1 2   ? 19.475  45.549  -48.486 1.00 58.26  ? 2   ARG B N   1 
ATOM   3942  C CA  . ARG B 1 2   ? 19.121  46.125  -49.774 1.00 61.24  ? 2   ARG B CA  1 
ATOM   3943  C C   . ARG B 1 2   ? 19.721  47.529  -49.944 1.00 64.48  ? 2   ARG B C   1 
ATOM   3944  O O   . ARG B 1 2   ? 20.030  48.217  -48.965 1.00 63.30  ? 2   ARG B O   1 
ATOM   3945  C CB  . ARG B 1 2   ? 17.601  46.193  -49.974 1.00 59.46  ? 2   ARG B CB  1 
ATOM   3946  C CG  . ARG B 1 2   ? 16.903  44.854  -50.195 1.00 64.74  ? 2   ARG B CG  1 
ATOM   3947  C CD  . ARG B 1 2   ? 15.428  45.017  -50.612 1.00 64.60  ? 2   ARG B CD  1 
ATOM   3948  N NE  . ARG B 1 2   ? 14.654  45.777  -49.620 1.00 62.67  ? 2   ARG B NE  1 
ATOM   3949  C CZ  . ARG B 1 2   ? 13.431  46.257  -49.786 1.00 59.88  ? 2   ARG B CZ  1 
ATOM   3950  N NH1 . ARG B 1 2   ? 12.803  46.117  -50.943 1.00 54.79  ? 2   ARG B NH1 1 
ATOM   3951  N NH2 . ARG B 1 2   ? 12.833  46.883  -48.788 1.00 63.45  ? 2   ARG B NH2 1 
ATOM   3952  N N   . THR B 1 3   ? 19.873  47.911  -51.225 1.00 66.62  ? 3   THR B N   1 
ATOM   3953  C CA  . THR B 1 3   ? 20.286  49.239  -51.664 1.00 61.57  ? 3   THR B CA  1 
ATOM   3954  C C   . THR B 1 3   ? 19.061  50.154  -51.730 1.00 59.98  ? 3   THR B C   1 
ATOM   3955  O O   . THR B 1 3   ? 17.918  49.697  -51.867 1.00 55.05  ? 3   THR B O   1 
ATOM   3956  C CB  . THR B 1 3   ? 20.958  49.183  -53.046 1.00 57.27  ? 3   THR B CB  1 
ATOM   3957  O OG1 . THR B 1 3   ? 19.907  48.846  -53.954 1.00 57.61  ? 3   THR B OG1 1 
ATOM   3958  C CG2 . THR B 1 3   ? 22.117  48.200  -53.158 1.00 48.72  ? 3   THR B CG2 1 
ATOM   3959  N N   . GLY B 1 4   ? 19.344  51.463  -51.691 1.00 54.44  ? 4   GLY B N   1 
ATOM   3960  C CA  . GLY B 1 4   ? 18.384  52.487  -52.061 1.00 54.34  ? 4   GLY B CA  1 
ATOM   3961  C C   . GLY B 1 4   ? 17.630  52.130  -53.339 1.00 51.54  ? 4   GLY B C   1 
ATOM   3962  O O   . GLY B 1 4   ? 16.392  52.177  -53.373 1.00 56.55  ? 4   GLY B O   1 
ATOM   3963  N N   . GLN B 1 5   ? 18.389  51.756  -54.376 1.00 59.59  ? 5   GLN B N   1 
ATOM   3964  C CA  . GLN B 1 5   ? 17.826  51.472  -55.689 1.00 63.05  ? 5   GLN B CA  1 
ATOM   3965  C C   . GLN B 1 5   ? 16.896  50.269  -55.588 1.00 57.12  ? 5   GLN B C   1 
ATOM   3966  O O   . GLN B 1 5   ? 15.796  50.290  -56.145 1.00 54.31  ? 5   GLN B O   1 
ATOM   3967  C CB  . GLN B 1 5   ? 18.909  51.245  -56.749 1.00 69.71  ? 5   GLN B CB  1 
ATOM   3968  C CG  . GLN B 1 5   ? 18.491  51.639  -58.162 1.00 83.68  ? 5   GLN B CG  1 
ATOM   3969  C CD  . GLN B 1 5   ? 18.414  53.139  -58.372 1.00 100.64 ? 5   GLN B CD  1 
ATOM   3970  O OE1 . GLN B 1 5   ? 17.681  53.856  -57.681 1.00 101.03 ? 5   GLN B OE1 1 
ATOM   3971  N NE2 . GLN B 1 5   ? 19.169  53.637  -59.342 1.00 108.25 ? 5   GLN B NE2 1 
ATOM   3972  N N   . GLN B 1 6   ? 17.328  49.234  -54.845 1.00 59.94  ? 6   GLN B N   1 
ATOM   3973  C CA  . GLN B 1 6   ? 16.511  48.034  -54.688 1.00 63.43  ? 6   GLN B CA  1 
ATOM   3974  C C   . GLN B 1 6   ? 15.223  48.399  -53.956 1.00 58.89  ? 6   GLN B C   1 
ATOM   3975  O O   . GLN B 1 6   ? 14.139  47.987  -54.369 1.00 56.56  ? 6   GLN B O   1 
ATOM   3976  C CB  . GLN B 1 6   ? 17.256  46.887  -54.003 1.00 69.41  ? 6   GLN B CB  1 
ATOM   3977  C CG  . GLN B 1 6   ? 18.163  46.087  -54.936 1.00 67.22  ? 6   GLN B CG  1 
ATOM   3978  C CD  . GLN B 1 6   ? 19.192  45.259  -54.198 1.00 70.36  ? 6   GLN B CD  1 
ATOM   3979  O OE1 . GLN B 1 6   ? 19.653  45.607  -53.104 1.00 74.05  ? 6   GLN B OE1 1 
ATOM   3980  N NE2 . GLN B 1 6   ? 19.595  44.160  -54.808 1.00 67.37  ? 6   GLN B NE2 1 
ATOM   3981  N N   . TYR B 1 7   ? 15.355  49.227  -52.908 1.00 64.25  ? 7   TYR B N   1 
ATOM   3982  C CA  . TYR B 1 7   ? 14.201  49.718  -52.169 1.00 61.23  ? 7   TYR B CA  1 
ATOM   3983  C C   . TYR B 1 7   ? 13.240  50.448  -53.113 1.00 60.09  ? 7   TYR B C   1 
ATOM   3984  O O   . TYR B 1 7   ? 12.040  50.149  -53.114 1.00 55.36  ? 7   TYR B O   1 
ATOM   3985  C CB  . TYR B 1 7   ? 14.624  50.574  -50.968 1.00 60.73  ? 7   TYR B CB  1 
ATOM   3986  C CG  . TYR B 1 7   ? 13.462  51.383  -50.415 1.00 55.75  ? 7   TYR B CG  1 
ATOM   3987  C CD1 . TYR B 1 7   ? 12.418  50.756  -49.743 1.00 55.83  ? 7   TYR B CD1 1 
ATOM   3988  C CD2 . TYR B 1 7   ? 13.370  52.758  -50.622 1.00 52.59  ? 7   TYR B CD2 1 
ATOM   3989  C CE1 . TYR B 1 7   ? 11.335  51.474  -49.263 1.00 54.83  ? 7   TYR B CE1 1 
ATOM   3990  C CE2 . TYR B 1 7   ? 12.292  53.487  -50.141 1.00 53.28  ? 7   TYR B CE2 1 
ATOM   3991  C CZ  . TYR B 1 7   ? 11.283  52.843  -49.451 1.00 51.48  ? 7   TYR B CZ  1 
ATOM   3992  O OH  . TYR B 1 7   ? 10.227  53.538  -48.973 1.00 52.56  ? 7   TYR B OH  1 
ATOM   3993  N N   . LEU B 1 8   ? 13.751  51.406  -53.910 1.00 57.65  ? 8   LEU B N   1 
ATOM   3994  C CA  . LEU B 1 8   ? 12.871  52.179  -54.777 1.00 54.59  ? 8   LEU B CA  1 
ATOM   3995  C C   . LEU B 1 8   ? 12.127  51.240  -55.731 1.00 56.33  ? 8   LEU B C   1 
ATOM   3996  O O   . LEU B 1 8   ? 10.904  51.342  -55.881 1.00 49.11  ? 8   LEU B O   1 
ATOM   3997  C CB  . LEU B 1 8   ? 13.632  53.277  -55.516 1.00 57.59  ? 8   LEU B CB  1 
ATOM   3998  C CG  . LEU B 1 8   ? 14.040  54.491  -54.669 1.00 71.24  ? 8   LEU B CG  1 
ATOM   3999  C CD1 . LEU B 1 8   ? 14.918  55.479  -55.422 1.00 67.50  ? 8   LEU B CD1 1 
ATOM   4000  C CD2 . LEU B 1 8   ? 12.815  55.217  -54.130 1.00 69.64  ? 8   LEU B CD2 1 
ATOM   4001  N N   . GLU B 1 9   ? 12.874  50.309  -56.351 1.00 61.50  ? 9   GLU B N   1 
ATOM   4002  C CA  . GLU B 1 9   ? 12.331  49.390  -57.347 1.00 60.02  ? 9   GLU B CA  1 
ATOM   4003  C C   . GLU B 1 9   ? 11.167  48.607  -56.737 1.00 57.66  ? 9   GLU B C   1 
ATOM   4004  O O   . GLU B 1 9   ? 10.118  48.475  -57.378 1.00 51.31  ? 9   GLU B O   1 
ATOM   4005  C CB  . GLU B 1 9   ? 13.439  48.491  -57.912 1.00 65.04  ? 9   GLU B CB  1 
ATOM   4006  C CG  . GLU B 1 9   ? 13.084  47.837  -59.249 1.00 79.15  ? 9   GLU B CG  1 
ATOM   4007  C CD  . GLU B 1 9   ? 12.511  48.766  -60.323 1.00 85.00  ? 9   GLU B CD  1 
ATOM   4008  O OE1 . GLU B 1 9   ? 13.105  49.840  -60.552 1.00 88.46  ? 9   GLU B OE1 1 
ATOM   4009  O OE2 . GLU B 1 9   ? 11.470  48.442  -60.937 1.00 72.51  ? 9   GLU B OE2 1 
ATOM   4010  N N   . SER B 1 10  ? 11.331  48.183  -55.467 1.00 52.48  ? 10  SER B N   1 
ATOM   4011  C CA  . SER B 1 10  ? 10.317  47.411  -54.757 1.00 55.63  ? 10  SER B CA  1 
ATOM   4012  C C   . SER B 1 10  ? 8.974   48.148  -54.635 1.00 54.43  ? 10  SER B C   1 
ATOM   4013  O O   . SER B 1 10  ? 7.932   47.481  -54.555 1.00 48.83  ? 10  SER B O   1 
ATOM   4014  C CB  . SER B 1 10  ? 10.828  46.926  -53.397 1.00 58.52  ? 10  SER B CB  1 
ATOM   4015  O OG  . SER B 1 10  ? 10.906  47.961  -52.422 1.00 59.12  ? 10  SER B OG  1 
ATOM   4016  N N   . LEU B 1 11  ? 8.964   49.500  -54.668 1.00 53.55  ? 11  LEU B N   1 
ATOM   4017  C CA  . LEU B 1 11  ? 7.717   50.253  -54.507 1.00 53.26  ? 11  LEU B CA  1 
ATOM   4018  C C   . LEU B 1 11  ? 6.923   50.345  -55.808 1.00 55.27  ? 11  LEU B C   1 
ATOM   4019  O O   . LEU B 1 11  ? 5.765   50.754  -55.764 1.00 56.57  ? 11  LEU B O   1 
ATOM   4020  C CB  . LEU B 1 11  ? 7.915   51.661  -53.962 1.00 54.47  ? 11  LEU B CB  1 
ATOM   4021  C CG  . LEU B 1 11  ? 8.627   51.771  -52.616 1.00 56.93  ? 11  LEU B CG  1 
ATOM   4022  C CD1 . LEU B 1 11  ? 8.926   53.240  -52.353 1.00 52.64  ? 11  LEU B CD1 1 
ATOM   4023  C CD2 . LEU B 1 11  ? 7.777   51.143  -51.518 1.00 63.69  ? 11  LEU B CD2 1 
ATOM   4024  N N   . ARG B 1 12  ? 7.533   49.959  -56.938 1.00 60.06  ? 12  ARG B N   1 
ATOM   4025  C CA  . ARG B 1 12  ? 6.876   49.979  -58.238 1.00 64.74  ? 12  ARG B CA  1 
ATOM   4026  C C   . ARG B 1 12  ? 6.282   48.606  -58.549 1.00 66.40  ? 12  ARG B C   1 
ATOM   4027  O O   . ARG B 1 12  ? 6.775   47.884  -59.406 1.00 73.99  ? 12  ARG B O   1 
ATOM   4028  C CB  . ARG B 1 12  ? 7.899   50.443  -59.279 1.00 62.74  ? 12  ARG B CB  1 
ATOM   4029  C CG  . ARG B 1 12  ? 8.311   51.878  -58.992 1.00 71.46  ? 12  ARG B CG  1 
ATOM   4030  C CD  . ARG B 1 12  ? 9.659   52.263  -59.541 1.00 72.19  ? 12  ARG B CD  1 
ATOM   4031  N NE  . ARG B 1 12  ? 9.576   52.723  -60.928 1.00 81.89  ? 12  ARG B NE  1 
ATOM   4032  C CZ  . ARG B 1 12  ? 10.660  52.999  -61.635 1.00 101.75 ? 12  ARG B CZ  1 
ATOM   4033  N NH1 . ARG B 1 12  ? 11.842  52.790  -61.080 1.00 110.59 ? 12  ARG B NH1 1 
ATOM   4034  N NH2 . ARG B 1 12  ? 10.572  53.469  -62.870 1.00 96.78  ? 12  ARG B NH2 1 
ATOM   4035  N N   . ASP B 1 13  ? 5.168   48.286  -57.890 1.00 65.95  ? 13  ASP B N   1 
ATOM   4036  C CA  . ASP B 1 13  ? 4.660   46.926  -57.839 1.00 58.78  ? 13  ASP B CA  1 
ATOM   4037  C C   . ASP B 1 13  ? 3.147   46.910  -58.034 1.00 55.20  ? 13  ASP B C   1 
ATOM   4038  O O   . ASP B 1 13  ? 2.502   45.943  -57.620 1.00 55.21  ? 13  ASP B O   1 
ATOM   4039  C CB  . ASP B 1 13  ? 5.049   46.269  -56.522 1.00 61.03  ? 13  ASP B CB  1 
ATOM   4040  C CG  . ASP B 1 13  ? 4.617   47.003  -55.251 1.00 61.28  ? 13  ASP B CG  1 
ATOM   4041  O OD1 . ASP B 1 13  ? 4.090   48.134  -55.356 1.00 62.77  ? 13  ASP B OD1 1 
ATOM   4042  O OD2 . ASP B 1 13  ? 4.793   46.435  -54.158 1.00 56.12  ? 13  ASP B OD2 1 
ATOM   4043  N N   . GLY B 1 14  ? 2.598   47.969  -58.660 1.00 48.78  ? 14  GLY B N   1 
ATOM   4044  C CA  . GLY B 1 14  ? 1.174   48.058  -58.971 1.00 48.91  ? 14  GLY B CA  1 
ATOM   4045  C C   . GLY B 1 14  ? 0.261   48.300  -57.758 1.00 53.47  ? 14  GLY B C   1 
ATOM   4046  O O   . GLY B 1 14  ? -0.968  48.187  -57.888 1.00 49.60  ? 14  GLY B O   1 
ATOM   4047  N N   . ARG B 1 15  ? 0.848   48.671  -56.600 1.00 54.43  ? 15  ARG B N   1 
ATOM   4048  C CA  . ARG B 1 15  ? 0.095   49.097  -55.418 1.00 54.95  ? 15  ARG B CA  1 
ATOM   4049  C C   . ARG B 1 15  ? -0.928  50.178  -55.765 1.00 49.72  ? 15  ARG B C   1 
ATOM   4050  O O   . ARG B 1 15  ? -0.653  51.046  -56.589 1.00 54.16  ? 15  ARG B O   1 
ATOM   4051  C CB  . ARG B 1 15  ? 1.016   49.714  -54.354 1.00 55.90  ? 15  ARG B CB  1 
ATOM   4052  C CG  . ARG B 1 15  ? 1.885   50.886  -54.803 1.00 54.10  ? 15  ARG B CG  1 
ATOM   4053  C CD  . ARG B 1 15  ? 2.954   51.244  -53.773 1.00 53.73  ? 15  ARG B CD  1 
ATOM   4054  N NE  . ARG B 1 15  ? 3.776   50.066  -53.457 1.00 54.97  ? 15  ARG B NE  1 
ATOM   4055  C CZ  . ARG B 1 15  ? 4.296   49.721  -52.285 1.00 53.50  ? 15  ARG B CZ  1 
ATOM   4056  N NH1 . ARG B 1 15  ? 4.422   50.568  -51.270 1.00 53.54  ? 15  ARG B NH1 1 
ATOM   4057  N NH2 . ARG B 1 15  ? 4.742   48.499  -52.149 1.00 53.52  ? 15  ARG B NH2 1 
ATOM   4058  N N   . GLN B 1 16  ? -2.096  50.111  -55.119 1.00 50.16  ? 16  GLN B N   1 
ATOM   4059  C CA  . GLN B 1 16  ? -3.164  51.088  -55.260 1.00 53.80  ? 16  GLN B CA  1 
ATOM   4060  C C   . GLN B 1 16  ? -3.071  52.113  -54.124 1.00 56.23  ? 16  GLN B C   1 
ATOM   4061  O O   . GLN B 1 16  ? -3.437  51.831  -52.975 1.00 52.87  ? 16  GLN B O   1 
ATOM   4062  C CB  . GLN B 1 16  ? -4.513  50.367  -55.289 1.00 61.98  ? 16  GLN B CB  1 
ATOM   4063  C CG  . GLN B 1 16  ? -4.740  49.486  -56.518 1.00 71.95  ? 16  GLN B CG  1 
ATOM   4064  C CD  . GLN B 1 16  ? -4.807  50.256  -57.824 1.00 75.21  ? 16  GLN B CD  1 
ATOM   4065  O OE1 . GLN B 1 16  ? -3.971  50.077  -58.719 1.00 74.41  ? 16  GLN B OE1 1 
ATOM   4066  N NE2 . GLN B 1 16  ? -5.805  51.119  -57.951 1.00 70.64  ? 16  GLN B NE2 1 
ATOM   4067  N N   . VAL B 1 17  ? -2.551  53.303  -54.453 1.00 56.03  ? 17  VAL B N   1 
ATOM   4068  C CA  . VAL B 1 17  ? -2.229  54.311  -53.452 1.00 57.83  ? 17  VAL B CA  1 
ATOM   4069  C C   . VAL B 1 17  ? -2.953  55.614  -53.775 1.00 54.25  ? 17  VAL B C   1 
ATOM   4070  O O   . VAL B 1 17  ? -2.728  56.197  -54.833 1.00 51.78  ? 17  VAL B O   1 
ATOM   4071  C CB  . VAL B 1 17  ? -0.718  54.546  -53.356 1.00 57.20  ? 17  VAL B CB  1 
ATOM   4072  C CG1 . VAL B 1 17  ? -0.381  55.682  -52.400 1.00 56.86  ? 17  VAL B CG1 1 
ATOM   4073  C CG2 . VAL B 1 17  ? -0.001  53.275  -52.932 1.00 60.93  ? 17  VAL B CG2 1 
ATOM   4074  N N   . TYR B 1 18  ? -3.842  56.016  -52.855 1.00 53.62  ? 18  TYR B N   1 
ATOM   4075  C CA  . TYR B 1 18  ? -4.544  57.287  -52.917 1.00 57.30  ? 18  TYR B CA  1 
ATOM   4076  C C   . TYR B 1 18  ? -3.901  58.287  -51.950 1.00 57.46  ? 18  TYR B C   1 
ATOM   4077  O O   . TYR B 1 18  ? -3.781  57.990  -50.763 1.00 56.35  ? 18  TYR B O   1 
ATOM   4078  C CB  . TYR B 1 18  ? -6.015  57.020  -52.599 1.00 53.81  ? 18  TYR B CB  1 
ATOM   4079  C CG  . TYR B 1 18  ? -6.748  56.173  -53.627 1.00 57.56  ? 18  TYR B CG  1 
ATOM   4080  C CD1 . TYR B 1 18  ? -6.656  54.784  -53.617 1.00 61.03  ? 18  TYR B CD1 1 
ATOM   4081  C CD2 . TYR B 1 18  ? -7.554  56.765  -54.595 1.00 58.60  ? 18  TYR B CD2 1 
ATOM   4082  C CE1 . TYR B 1 18  ? -7.340  54.009  -54.546 1.00 59.89  ? 18  TYR B CE1 1 
ATOM   4083  C CE2 . TYR B 1 18  ? -8.239  56.006  -55.530 1.00 57.94  ? 18  TYR B CE2 1 
ATOM   4084  C CZ  . TYR B 1 18  ? -8.124  54.625  -55.510 1.00 63.74  ? 18  TYR B CZ  1 
ATOM   4085  O OH  . TYR B 1 18  ? -8.806  53.883  -56.429 1.00 60.00  ? 18  TYR B OH  1 
ATOM   4086  N N   . VAL B 1 19  ? -3.516  59.466  -52.469 1.00 53.63  ? 19  VAL B N   1 
ATOM   4087  C CA  . VAL B 1 19  ? -2.997  60.570  -51.671 1.00 57.23  ? 19  VAL B CA  1 
ATOM   4088  C C   . VAL B 1 19  ? -3.850  61.814  -51.940 1.00 57.99  ? 19  VAL B C   1 
ATOM   4089  O O   . VAL B 1 19  ? -3.757  62.419  -53.009 1.00 54.90  ? 19  VAL B O   1 
ATOM   4090  C CB  . VAL B 1 19  ? -1.509  60.891  -51.927 1.00 54.75  ? 19  VAL B CB  1 
ATOM   4091  C CG1 . VAL B 1 19  ? -1.050  62.100  -51.117 1.00 50.68  ? 19  VAL B CG1 1 
ATOM   4092  C CG2 . VAL B 1 19  ? -0.594  59.698  -51.662 1.00 55.45  ? 19  VAL B CG2 1 
ATOM   4093  N N   . GLY B 1 20  ? -4.641  62.221  -50.937 1.00 56.28  ? 20  GLY B N   1 
ATOM   4094  C CA  . GLY B 1 20  ? -5.549  63.348  -51.068 1.00 57.12  ? 20  GLY B CA  1 
ATOM   4095  C C   . GLY B 1 20  ? -6.726  63.013  -51.984 1.00 58.20  ? 20  GLY B C   1 
ATOM   4096  O O   . GLY B 1 20  ? -7.522  63.888  -52.312 1.00 63.11  ? 20  GLY B O   1 
ATOM   4097  N N   . GLY B 1 21  ? -6.840  61.734  -52.372 1.00 63.85  ? 21  GLY B N   1 
ATOM   4098  C CA  . GLY B 1 21  ? -7.882  61.263  -53.273 1.00 61.03  ? 21  GLY B CA  1 
ATOM   4099  C C   . GLY B 1 21  ? -7.364  60.975  -54.687 1.00 57.54  ? 21  GLY B C   1 
ATOM   4100  O O   . GLY B 1 21  ? -8.072  60.388  -55.492 1.00 59.98  ? 21  GLY B O   1 
ATOM   4101  N N   . GLU B 1 22  ? -6.153  61.416  -55.020 1.00 55.08  ? 22  GLU B N   1 
ATOM   4102  C CA  . GLU B 1 22  ? -5.575  61.129  -56.321 1.00 57.94  ? 22  GLU B CA  1 
ATOM   4103  C C   . GLU B 1 22  ? -4.976  59.728  -56.296 1.00 60.23  ? 22  GLU B C   1 
ATOM   4104  O O   . GLU B 1 22  ? -4.259  59.400  -55.359 1.00 62.67  ? 22  GLU B O   1 
ATOM   4105  C CB  . GLU B 1 22  ? -4.480  62.156  -56.604 1.00 58.41  ? 22  GLU B CB  1 
ATOM   4106  C CG  . GLU B 1 22  ? -3.762  61.955  -57.939 1.00 59.40  ? 22  GLU B CG  1 
ATOM   4107  C CD  . GLU B 1 22  ? -2.590  62.906  -58.141 1.00 57.38  ? 22  GLU B CD  1 
ATOM   4108  O OE1 . GLU B 1 22  ? -2.333  63.788  -57.296 1.00 57.39  ? 22  GLU B OE1 1 
ATOM   4109  O OE2 . GLU B 1 22  ? -1.900  62.739  -59.152 1.00 54.97  ? 22  GLU B OE2 1 
ATOM   4110  N N   . LEU B 1 23  ? -5.252  58.916  -57.322 1.00 58.19  ? 23  LEU B N   1 
ATOM   4111  C CA  . LEU B 1 23  ? -4.569  57.642  -57.481 1.00 54.50  ? 23  LEU B CA  1 
ATOM   4112  C C   . LEU B 1 23  ? -3.152  57.892  -58.005 1.00 55.40  ? 23  LEU B C   1 
ATOM   4113  O O   . LEU B 1 23  ? -2.992  58.509  -59.049 1.00 57.18  ? 23  LEU B O   1 
ATOM   4114  C CB  . LEU B 1 23  ? -5.363  56.750  -58.427 1.00 59.37  ? 23  LEU B CB  1 
ATOM   4115  C CG  . LEU B 1 23  ? -4.778  55.360  -58.697 1.00 66.14  ? 23  LEU B CG  1 
ATOM   4116  C CD1 . LEU B 1 23  ? -4.679  54.520  -57.437 1.00 67.91  ? 23  LEU B CD1 1 
ATOM   4117  C CD2 . LEU B 1 23  ? -5.627  54.658  -59.750 1.00 73.36  ? 23  LEU B CD2 1 
ATOM   4118  N N   . ILE B 1 24  ? -2.136  57.424  -57.258 1.00 52.69  ? 24  ILE B N   1 
ATOM   4119  C CA  . ILE B 1 24  ? -0.733  57.629  -57.587 1.00 56.03  ? 24  ILE B CA  1 
ATOM   4120  C C   . ILE B 1 24  ? -0.228  56.450  -58.417 1.00 59.78  ? 24  ILE B C   1 
ATOM   4121  O O   . ILE B 1 24  ? -0.160  55.330  -57.924 1.00 67.51  ? 24  ILE B O   1 
ATOM   4122  C CB  . ILE B 1 24  ? 0.127   57.821  -56.321 1.00 56.42  ? 24  ILE B CB  1 
ATOM   4123  C CG1 . ILE B 1 24  ? -0.024  59.217  -55.714 1.00 68.13  ? 24  ILE B CG1 1 
ATOM   4124  C CG2 . ILE B 1 24  ? 1.596   57.558  -56.639 1.00 58.36  ? 24  ILE B CG2 1 
ATOM   4125  C CD1 . ILE B 1 24  ? -1.422  59.583  -55.258 1.00 70.81  ? 24  ILE B CD1 1 
ATOM   4126  N N   . ASP B 1 25  ? 0.165   56.750  -59.660 1.00 63.12  ? 25  ASP B N   1 
ATOM   4127  C CA  . ASP B 1 25  ? 0.714   55.802  -60.620 1.00 66.26  ? 25  ASP B CA  1 
ATOM   4128  C C   . ASP B 1 25  ? 2.029   55.190  -60.116 1.00 61.68  ? 25  ASP B C   1 
ATOM   4129  O O   . ASP B 1 25  ? 2.263   53.992  -60.243 1.00 60.75  ? 25  ASP B O   1 
ATOM   4130  C CB  . ASP B 1 25  ? 0.887   56.486  -61.974 1.00 70.11  ? 25  ASP B CB  1 
ATOM   4131  C CG  . ASP B 1 25  ? 1.655   57.814  -62.015 1.00 79.69  ? 25  ASP B CG  1 
ATOM   4132  O OD1 . ASP B 1 25  ? 1.950   58.414  -60.941 1.00 76.44  ? 25  ASP B OD1 1 
ATOM   4133  O OD2 . ASP B 1 25  ? 1.966   58.267  -63.137 1.00 79.26  ? 25  ASP B OD2 1 
ATOM   4134  N N   . ASP B 1 26  ? 2.912   56.038  -59.586 1.00 59.21  ? 26  ASP B N   1 
ATOM   4135  C CA  . ASP B 1 26  ? 4.263   55.645  -59.230 1.00 61.63  ? 26  ASP B CA  1 
ATOM   4136  C C   . ASP B 1 26  ? 4.735   56.538  -58.075 1.00 64.71  ? 26  ASP B C   1 
ATOM   4137  O O   . ASP B 1 26  ? 4.940   57.746  -58.243 1.00 61.89  ? 26  ASP B O   1 
ATOM   4138  C CB  . ASP B 1 26  ? 5.160   55.639  -60.461 1.00 59.89  ? 26  ASP B CB  1 
ATOM   4139  C CG  . ASP B 1 26  ? 6.613   55.265  -60.213 1.00 62.24  ? 26  ASP B CG  1 
ATOM   4140  O OD1 . ASP B 1 26  ? 6.999   55.157  -59.028 1.00 59.55  ? 26  ASP B OD1 1 
ATOM   4141  O OD2 . ASP B 1 26  ? 7.350   55.095  -61.207 1.00 74.86  ? 26  ASP B OD2 1 
ATOM   4142  N N   . VAL B 1 27  ? 4.910   55.902  -56.909 1.00 54.16  ? 27  VAL B N   1 
ATOM   4143  C CA  . VAL B 1 27  ? 5.198   56.577  -55.660 1.00 52.86  ? 27  VAL B CA  1 
ATOM   4144  C C   . VAL B 1 27  ? 6.613   57.154  -55.674 1.00 56.42  ? 27  VAL B C   1 
ATOM   4145  O O   . VAL B 1 27  ? 6.893   58.152  -54.992 1.00 50.38  ? 27  VAL B O   1 
ATOM   4146  C CB  . VAL B 1 27  ? 4.979   55.519  -54.562 1.00 60.62  ? 27  VAL B CB  1 
ATOM   4147  C CG1 . VAL B 1 27  ? 5.746   55.822  -53.290 1.00 68.44  ? 27  VAL B CG1 1 
ATOM   4148  C CG2 . VAL B 1 27  ? 3.496   55.338  -54.263 1.00 63.55  ? 27  VAL B CG2 1 
ATOM   4149  N N   . THR B 1 28  ? 7.492   56.537  -56.480 1.00 55.28  ? 28  THR B N   1 
ATOM   4150  C CA  . THR B 1 28  ? 8.884   56.959  -56.565 1.00 58.87  ? 28  THR B CA  1 
ATOM   4151  C C   . THR B 1 28  ? 9.066   58.170  -57.493 1.00 59.02  ? 28  THR B C   1 
ATOM   4152  O O   . THR B 1 28  ? 10.170  58.717  -57.542 1.00 56.16  ? 28  THR B O   1 
ATOM   4153  C CB  . THR B 1 28  ? 9.751   55.780  -57.025 1.00 62.80  ? 28  THR B CB  1 
ATOM   4154  O OG1 . THR B 1 28  ? 9.413   55.507  -58.385 1.00 56.04  ? 28  THR B OG1 1 
ATOM   4155  C CG2 . THR B 1 28  ? 9.570   54.540  -56.161 1.00 62.60  ? 28  THR B CG2 1 
ATOM   4156  N N   . THR B 1 29  ? 8.031   58.570  -58.262 1.00 62.12  ? 29  THR B N   1 
ATOM   4157  C CA  . THR B 1 29  ? 8.175   59.673  -59.215 1.00 63.59  ? 29  THR B CA  1 
ATOM   4158  C C   . THR B 1 29  ? 7.135   60.769  -58.977 1.00 59.28  ? 29  THR B C   1 
ATOM   4159  O O   . THR B 1 29  ? 7.373   61.917  -59.355 1.00 63.73  ? 29  THR B O   1 
ATOM   4160  C CB  . THR B 1 29  ? 8.121   59.215  -60.681 1.00 59.17  ? 29  THR B CB  1 
ATOM   4161  O OG1 . THR B 1 29  ? 6.832   58.639  -60.943 1.00 53.44  ? 29  THR B OG1 1 
ATOM   4162  C CG2 . THR B 1 29  ? 9.298   58.318  -61.039 1.00 55.62  ? 29  THR B CG2 1 
ATOM   4163  N N   . HIS B 1 30  ? 5.958   60.423  -58.445 1.00 50.98  ? 30  HIS B N   1 
ATOM   4164  C CA  . HIS B 1 30  ? 4.950   61.441  -58.218 1.00 50.15  ? 30  HIS B CA  1 
ATOM   4165  C C   . HIS B 1 30  ? 5.510   62.529  -57.277 1.00 61.90  ? 30  HIS B C   1 
ATOM   4166  O O   . HIS B 1 30  ? 6.113   62.246  -56.236 1.00 55.56  ? 30  HIS B O   1 
ATOM   4167  C CB  . HIS B 1 30  ? 3.686   60.812  -57.645 1.00 48.29  ? 30  HIS B CB  1 
ATOM   4168  C CG  . HIS B 1 30  ? 2.472   61.674  -57.798 1.00 56.90  ? 30  HIS B CG  1 
ATOM   4169  N ND1 . HIS B 1 30  ? 2.264   62.838  -57.081 1.00 53.54  ? 30  HIS B ND1 1 
ATOM   4170  C CD2 . HIS B 1 30  ? 1.396   61.530  -58.612 1.00 51.33  ? 30  HIS B CD2 1 
ATOM   4171  C CE1 . HIS B 1 30  ? 1.082   63.352  -57.427 1.00 58.62  ? 30  HIS B CE1 1 
ATOM   4172  N NE2 . HIS B 1 30  ? 0.536   62.576  -58.359 1.00 54.91  ? 30  HIS B NE2 1 
ATOM   4173  N N   . PRO B 1 31  ? 5.382   63.832  -57.613 1.00 54.65  ? 31  PRO B N   1 
ATOM   4174  C CA  . PRO B 1 31  ? 5.802   64.881  -56.682 1.00 49.13  ? 31  PRO B CA  1 
ATOM   4175  C C   . PRO B 1 31  ? 5.256   64.730  -55.258 1.00 51.50  ? 31  PRO B C   1 
ATOM   4176  O O   . PRO B 1 31  ? 5.924   65.129  -54.309 1.00 56.62  ? 31  PRO B O   1 
ATOM   4177  C CB  . PRO B 1 31  ? 5.319   66.191  -57.348 1.00 54.09  ? 31  PRO B CB  1 
ATOM   4178  C CG  . PRO B 1 31  ? 5.116   65.844  -58.833 1.00 57.50  ? 31  PRO B CG  1 
ATOM   4179  C CD  . PRO B 1 31  ? 4.835   64.344  -58.886 1.00 55.48  ? 31  PRO B CD  1 
ATOM   4180  N N   . LYS B 1 32  ? 4.056   64.145  -55.092 1.00 51.35  ? 32  LYS B N   1 
ATOM   4181  C CA  . LYS B 1 32  ? 3.423   64.073  -53.782 1.00 50.56  ? 32  LYS B CA  1 
ATOM   4182  C C   . LYS B 1 32  ? 4.171   63.115  -52.853 1.00 52.73  ? 32  LYS B C   1 
ATOM   4183  O O   . LYS B 1 32  ? 4.106   63.327  -51.644 1.00 50.15  ? 32  LYS B O   1 
ATOM   4184  C CB  . LYS B 1 32  ? 1.931   63.704  -53.764 1.00 50.41  ? 32  LYS B CB  1 
ATOM   4185  C CG  . LYS B 1 32  ? 0.964   64.773  -54.268 1.00 54.80  ? 32  LYS B CG  1 
ATOM   4186  C CD  . LYS B 1 32  ? -0.497  64.318  -54.305 1.00 55.58  ? 32  LYS B CD  1 
ATOM   4187  C CE  . LYS B 1 32  ? -1.493  65.385  -54.648 1.00 54.66  ? 32  LYS B CE  1 
ATOM   4188  N NZ  . LYS B 1 32  ? -2.873  64.966  -54.365 1.00 60.24  ? 32  LYS B NZ  1 
ATOM   4189  N N   . THR B 1 33  ? 4.869   62.096  -53.403 1.00 53.89  ? 33  THR B N   1 
ATOM   4190  C CA  . THR B 1 33  ? 5.466   61.022  -52.601 1.00 54.74  ? 33  THR B CA  1 
ATOM   4191  C C   . THR B 1 33  ? 6.980   60.839  -52.815 1.00 55.62  ? 33  THR B C   1 
ATOM   4192  O O   . THR B 1 33  ? 7.658   60.234  -51.979 1.00 47.50  ? 33  THR B O   1 
ATOM   4193  C CB  . THR B 1 33  ? 4.716   59.718  -52.882 1.00 54.66  ? 33  THR B CB  1 
ATOM   4194  O OG1 . THR B 1 33  ? 4.829   59.411  -54.270 1.00 50.75  ? 33  THR B OG1 1 
ATOM   4195  C CG2 . THR B 1 33  ? 3.256   59.808  -52.481 1.00 52.62  ? 33  THR B CG2 1 
ATOM   4196  N N   . SER B 1 34  ? 7.533   61.357  -53.919 1.00 58.02  ? 34  SER B N   1 
ATOM   4197  C CA  . SER B 1 34  ? 8.857   60.953  -54.371 1.00 55.80  ? 34  SER B CA  1 
ATOM   4198  C C   . SER B 1 34  ? 9.924   61.269  -53.325 1.00 48.64  ? 34  SER B C   1 
ATOM   4199  O O   . SER B 1 34  ? 10.878  60.513  -53.188 1.00 46.00  ? 34  SER B O   1 
ATOM   4200  C CB  . SER B 1 34  ? 9.213   61.598  -55.702 1.00 56.31  ? 34  SER B CB  1 
ATOM   4201  O OG  . SER B 1 34  ? 9.432   62.996  -55.555 1.00 52.94  ? 34  SER B OG  1 
ATOM   4202  N N   . GLY B 1 35  ? 9.775   62.424  -52.658 1.00 52.34  ? 35  GLY B N   1 
ATOM   4203  C CA  . GLY B 1 35  ? 10.778  62.956  -51.742 1.00 49.94  ? 35  GLY B CA  1 
ATOM   4204  C C   . GLY B 1 35  ? 10.969  62.079  -50.498 1.00 53.51  ? 35  GLY B C   1 
ATOM   4205  O O   . GLY B 1 35  ? 12.110  61.781  -50.142 1.00 52.11  ? 35  GLY B O   1 
ATOM   4206  N N   . TYR B 1 36  ? 9.869   61.660  -49.839 1.00 45.79  ? 36  TYR B N   1 
ATOM   4207  C CA  . TYR B 1 36  ? 9.988   60.717  -48.737 1.00 53.83  ? 36  TYR B CA  1 
ATOM   4208  C C   . TYR B 1 36  ? 10.502  59.352  -49.237 1.00 58.00  ? 36  TYR B C   1 
ATOM   4209  O O   . TYR B 1 36  ? 11.374  58.740  -48.603 1.00 50.70  ? 36  TYR B O   1 
ATOM   4210  C CB  . TYR B 1 36  ? 8.670   60.680  -47.966 1.00 51.93  ? 36  TYR B CB  1 
ATOM   4211  C CG  . TYR B 1 36  ? 8.734   59.746  -46.768 1.00 52.05  ? 36  TYR B CG  1 
ATOM   4212  C CD1 . TYR B 1 36  ? 9.316   60.140  -45.572 1.00 54.92  ? 36  TYR B CD1 1 
ATOM   4213  C CD2 . TYR B 1 36  ? 8.214   58.465  -46.843 1.00 53.22  ? 36  TYR B CD2 1 
ATOM   4214  C CE1 . TYR B 1 36  ? 9.358   59.290  -44.480 1.00 51.63  ? 36  TYR B CE1 1 
ATOM   4215  C CE2 . TYR B 1 36  ? 8.241   57.607  -45.761 1.00 57.70  ? 36  TYR B CE2 1 
ATOM   4216  C CZ  . TYR B 1 36  ? 8.828   58.015  -44.575 1.00 56.43  ? 36  TYR B CZ  1 
ATOM   4217  O OH  . TYR B 1 36  ? 8.871   57.138  -43.517 1.00 49.15  ? 36  TYR B OH  1 
ATOM   4218  N N   . ALA B 1 37  ? 10.030  58.899  -50.408 1.00 53.20  ? 37  ALA B N   1 
ATOM   4219  C CA  . ALA B 1 37  ? 10.560  57.683  -51.014 1.00 62.17  ? 37  ALA B CA  1 
ATOM   4220  C C   . ALA B 1 37  ? 12.088  57.717  -51.061 1.00 62.29  ? 37  ALA B C   1 
ATOM   4221  O O   . ALA B 1 37  ? 12.753  56.762  -50.656 1.00 66.70  ? 37  ALA B O   1 
ATOM   4222  C CB  . ALA B 1 37  ? 9.976   57.485  -52.390 1.00 58.85  ? 37  ALA B CB  1 
ATOM   4223  N N   . LYS B 1 38  ? 12.633  58.837  -51.535 1.00 60.41  ? 38  LYS B N   1 
ATOM   4224  C CA  . LYS B 1 38  ? 14.064  58.989  -51.730 1.00 63.79  ? 38  LYS B CA  1 
ATOM   4225  C C   . LYS B 1 38  ? 14.779  59.135  -50.377 1.00 65.59  ? 38  LYS B C   1 
ATOM   4226  O O   . LYS B 1 38  ? 15.963  58.817  -50.254 1.00 54.12  ? 38  LYS B O   1 
ATOM   4227  C CB  . LYS B 1 38  ? 14.222  60.131  -52.743 1.00 67.14  ? 38  LYS B CB  1 
ATOM   4228  C CG  . LYS B 1 38  ? 15.636  60.405  -53.223 1.00 77.56  ? 38  LYS B CG  1 
ATOM   4229  C CD  . LYS B 1 38  ? 15.702  60.959  -54.644 1.00 90.92  ? 38  LYS B CD  1 
ATOM   4230  C CE  . LYS B 1 38  ? 15.347  59.944  -55.701 1.00 99.24  ? 38  LYS B CE  1 
ATOM   4231  N NZ  . LYS B 1 38  ? 16.326  58.851  -55.773 1.00 99.97  ? 38  LYS B NZ  1 
ATOM   4232  N N   . ALA B 1 39  ? 14.076  59.602  -49.336 1.00 59.57  ? 39  ALA B N   1 
ATOM   4233  C CA  . ALA B 1 39  ? 14.720  59.753  -48.039 1.00 57.27  ? 39  ALA B CA  1 
ATOM   4234  C C   . ALA B 1 39  ? 14.888  58.378  -47.399 1.00 59.19  ? 39  ALA B C   1 
ATOM   4235  O O   . ALA B 1 39  ? 15.872  58.141  -46.706 1.00 63.18  ? 39  ALA B O   1 
ATOM   4236  C CB  . ALA B 1 39  ? 13.953  60.700  -47.138 1.00 57.85  ? 39  ALA B CB  1 
ATOM   4237  N N   . ILE B 1 40  ? 13.944  57.462  -47.653 1.00 60.07  ? 40  ILE B N   1 
ATOM   4238  C CA  . ILE B 1 40  ? 14.063  56.104  -47.136 1.00 59.39  ? 40  ILE B CA  1 
ATOM   4239  C C   . ILE B 1 40  ? 15.105  55.346  -47.974 1.00 58.83  ? 40  ILE B C   1 
ATOM   4240  O O   . ILE B 1 40  ? 15.870  54.542  -47.432 1.00 53.21  ? 40  ILE B O   1 
ATOM   4241  C CB  . ILE B 1 40  ? 12.682  55.411  -47.035 1.00 57.98  ? 40  ILE B CB  1 
ATOM   4242  C CG1 . ILE B 1 40  ? 11.705  56.205  -46.148 1.00 57.03  ? 40  ILE B CG1 1 
ATOM   4243  C CG2 . ILE B 1 40  ? 12.789  53.971  -46.530 1.00 55.30  ? 40  ILE B CG2 1 
ATOM   4244  C CD1 . ILE B 1 40  ? 12.212  56.483  -44.740 1.00 53.14  ? 40  ILE B CD1 1 
ATOM   4245  N N   . ALA B 1 41  ? 15.180  55.646  -49.280 1.00 54.20  ? 41  ALA B N   1 
ATOM   4246  C CA  . ALA B 1 41  ? 16.209  55.063  -50.127 1.00 55.75  ? 41  ALA B CA  1 
ATOM   4247  C C   . ALA B 1 41  ? 17.611  55.420  -49.610 1.00 56.38  ? 41  ALA B C   1 
ATOM   4248  O O   . ALA B 1 41  ? 18.489  54.556  -49.537 1.00 54.80  ? 41  ALA B O   1 
ATOM   4249  C CB  . ALA B 1 41  ? 15.985  55.481  -51.564 1.00 54.39  ? 41  ALA B CB  1 
ATOM   4250  N N   . GLU B 1 42  ? 17.817  56.683  -49.213 1.00 60.28  ? 42  GLU B N   1 
ATOM   4251  C CA  . GLU B 1 42  ? 19.094  57.119  -48.669 1.00 60.36  ? 42  GLU B CA  1 
ATOM   4252  C C   . GLU B 1 42  ? 19.332  56.381  -47.352 1.00 58.52  ? 42  GLU B C   1 
ATOM   4253  O O   . GLU B 1 42  ? 20.472  56.011  -47.071 1.00 58.65  ? 42  GLU B O   1 
ATOM   4254  C CB  . GLU B 1 42  ? 19.228  58.641  -48.494 1.00 61.98  ? 42  GLU B CB  1 
ATOM   4255  C CG  . GLU B 1 42  ? 20.688  59.121  -48.520 1.00 73.35  ? 42  GLU B CG  1 
ATOM   4256  C CD  . GLU B 1 42  ? 21.120  60.371  -47.733 1.00 79.04  ? 42  GLU B CD  1 
ATOM   4257  O OE1 . GLU B 1 42  ? 22.349  60.585  -47.617 1.00 81.84  ? 42  GLU B OE1 1 
ATOM   4258  O OE2 . GLU B 1 42  ? 20.287  61.147  -47.221 1.00 71.70  ? 42  GLU B OE2 1 
ATOM   4259  N N   . TYR B 1 43  ? 18.259  56.167  -46.566 1.00 51.82  ? 43  TYR B N   1 
ATOM   4260  C CA  . TYR B 1 43  ? 18.325  55.408  -45.319 1.00 58.80  ? 43  TYR B CA  1 
ATOM   4261  C C   . TYR B 1 43  ? 18.975  54.039  -45.556 1.00 62.93  ? 43  TYR B C   1 
ATOM   4262  O O   . TYR B 1 43  ? 19.894  53.651  -44.810 1.00 61.54  ? 43  TYR B O   1 
ATOM   4263  C CB  . TYR B 1 43  ? 16.929  55.306  -44.678 1.00 58.53  ? 43  TYR B CB  1 
ATOM   4264  C CG  . TYR B 1 43  ? 16.697  54.307  -43.543 1.00 53.50  ? 43  TYR B CG  1 
ATOM   4265  C CD1 . TYR B 1 43  ? 16.394  52.973  -43.817 1.00 55.89  ? 43  TYR B CD1 1 
ATOM   4266  C CD2 . TYR B 1 43  ? 16.718  54.693  -42.202 1.00 52.37  ? 43  TYR B CD2 1 
ATOM   4267  C CE1 . TYR B 1 43  ? 16.154  52.055  -42.806 1.00 52.44  ? 43  TYR B CE1 1 
ATOM   4268  C CE2 . TYR B 1 43  ? 16.482  53.781  -41.179 1.00 52.20  ? 43  TYR B CE2 1 
ATOM   4269  C CZ  . TYR B 1 43  ? 16.193  52.454  -41.478 1.00 52.65  ? 43  TYR B CZ  1 
ATOM   4270  O OH  . TYR B 1 43  ? 15.964  51.513  -40.496 1.00 44.07  ? 43  TYR B OH  1 
ATOM   4271  N N   . TYR B 1 44  ? 18.506  53.313  -46.590 1.00 54.53  ? 44  TYR B N   1 
ATOM   4272  C CA  . TYR B 1 44  ? 19.045  51.984  -46.899 1.00 59.98  ? 44  TYR B CA  1 
ATOM   4273  C C   . TYR B 1 44  ? 20.522  52.064  -47.322 1.00 53.80  ? 44  TYR B C   1 
ATOM   4274  O O   . TYR B 1 44  ? 21.310  51.198  -46.939 1.00 65.80  ? 44  TYR B O   1 
ATOM   4275  C CB  . TYR B 1 44  ? 18.206  51.219  -47.933 1.00 54.50  ? 44  TYR B CB  1 
ATOM   4276  C CG  . TYR B 1 44  ? 16.955  50.539  -47.389 1.00 53.28  ? 44  TYR B CG  1 
ATOM   4277  C CD1 . TYR B 1 44  ? 17.011  49.249  -46.871 1.00 58.69  ? 44  TYR B CD1 1 
ATOM   4278  C CD2 . TYR B 1 44  ? 15.709  51.163  -47.421 1.00 55.94  ? 44  TYR B CD2 1 
ATOM   4279  C CE1 . TYR B 1 44  ? 15.878  48.602  -46.397 1.00 58.11  ? 44  TYR B CE1 1 
ATOM   4280  C CE2 . TYR B 1 44  ? 14.572  50.542  -46.922 1.00 56.64  ? 44  TYR B CE2 1 
ATOM   4281  C CZ  . TYR B 1 44  ? 14.656  49.254  -46.410 1.00 59.20  ? 44  TYR B CZ  1 
ATOM   4282  O OH  . TYR B 1 44  ? 13.552  48.607  -45.926 1.00 57.43  ? 44  TYR B OH  1 
ATOM   4283  N N   . ASP B 1 45  ? 20.907  53.108  -48.072 1.00 54.34  ? 45  ASP B N   1 
ATOM   4284  C CA  . ASP B 1 45  ? 22.258  53.228  -48.622 1.00 59.96  ? 45  ASP B CA  1 
ATOM   4285  C C   . ASP B 1 45  ? 23.269  53.524  -47.526 1.00 53.41  ? 45  ASP B C   1 
ATOM   4286  O O   . ASP B 1 45  ? 24.396  53.064  -47.611 1.00 55.55  ? 45  ASP B O   1 
ATOM   4287  C CB  . ASP B 1 45  ? 22.382  54.316  -49.682 1.00 60.05  ? 45  ASP B CB  1 
ATOM   4288  C CG  . ASP B 1 45  ? 21.837  53.956  -51.052 1.00 57.63  ? 45  ASP B CG  1 
ATOM   4289  O OD1 . ASP B 1 45  ? 21.821  52.756  -51.380 1.00 62.46  ? 45  ASP B OD1 1 
ATOM   4290  O OD2 . ASP B 1 45  ? 21.386  54.878  -51.755 1.00 62.22  ? 45  ASP B OD2 1 
ATOM   4291  N N   . LEU B 1 46  ? 22.860  54.293  -46.511 1.00 58.64  ? 46  LEU B N   1 
ATOM   4292  C CA  . LEU B 1 46  ? 23.731  54.588  -45.385 1.00 64.10  ? 46  LEU B CA  1 
ATOM   4293  C C   . LEU B 1 46  ? 24.076  53.325  -44.602 1.00 61.38  ? 46  LEU B C   1 
ATOM   4294  O O   . LEU B 1 46  ? 25.183  53.209  -44.086 1.00 59.36  ? 46  LEU B O   1 
ATOM   4295  C CB  . LEU B 1 46  ? 23.071  55.647  -44.511 1.00 64.97  ? 46  LEU B CB  1 
ATOM   4296  C CG  . LEU B 1 46  ? 23.070  57.049  -45.128 1.00 70.83  ? 46  LEU B CG  1 
ATOM   4297  C CD1 . LEU B 1 46  ? 22.235  58.031  -44.314 1.00 72.59  ? 46  LEU B CD1 1 
ATOM   4298  C CD2 . LEU B 1 46  ? 24.503  57.536  -45.269 1.00 69.84  ? 46  LEU B CD2 1 
ATOM   4299  N N   . HIS B 1 47  ? 23.148  52.369  -44.532 1.00 63.37  ? 47  HIS B N   1 
ATOM   4300  C CA  . HIS B 1 47  ? 23.429  51.107  -43.861 1.00 67.70  ? 47  HIS B CA  1 
ATOM   4301  C C   . HIS B 1 47  ? 24.558  50.336  -44.550 1.00 65.23  ? 47  HIS B C   1 
ATOM   4302  O O   . HIS B 1 47  ? 25.306  49.609  -43.887 1.00 57.78  ? 47  HIS B O   1 
ATOM   4303  C CB  . HIS B 1 47  ? 22.176  50.236  -43.781 1.00 62.79  ? 47  HIS B CB  1 
ATOM   4304  C CG  . HIS B 1 47  ? 21.217  50.640  -42.720 1.00 62.55  ? 47  HIS B CG  1 
ATOM   4305  N ND1 . HIS B 1 47  ? 20.213  51.559  -42.926 1.00 63.83  ? 47  HIS B ND1 1 
ATOM   4306  C CD2 . HIS B 1 47  ? 21.094  50.223  -41.453 1.00 62.10  ? 47  HIS B CD2 1 
ATOM   4307  C CE1 . HIS B 1 47  ? 19.501  51.668  -41.813 1.00 64.88  ? 47  HIS B CE1 1 
ATOM   4308  N NE2 . HIS B 1 47  ? 20.019  50.867  -40.907 1.00 60.96  ? 47  HIS B NE2 1 
ATOM   4309  N N   . LEU B 1 48  ? 24.671  50.478  -45.876 1.00 62.57  ? 48  LEU B N   1 
ATOM   4310  C CA  . LEU B 1 48  ? 25.706  49.776  -46.622 1.00 63.59  ? 48  LEU B CA  1 
ATOM   4311  C C   . LEU B 1 48  ? 27.040  50.529  -46.568 1.00 66.62  ? 48  LEU B C   1 
ATOM   4312  O O   . LEU B 1 48  ? 28.077  49.925  -46.834 1.00 68.34  ? 48  LEU B O   1 
ATOM   4313  C CB  . LEU B 1 48  ? 25.202  49.534  -48.046 1.00 63.30  ? 48  LEU B CB  1 
ATOM   4314  C CG  . LEU B 1 48  ? 24.147  48.426  -48.177 1.00 64.41  ? 48  LEU B CG  1 
ATOM   4315  C CD1 . LEU B 1 48  ? 23.367  48.505  -49.480 1.00 61.30  ? 48  LEU B CD1 1 
ATOM   4316  C CD2 . LEU B 1 48  ? 24.781  47.037  -48.027 1.00 59.57  ? 48  LEU B CD2 1 
ATOM   4317  N N   . ASP B 1 49  ? 27.010  51.826  -46.207 1.00 71.55  ? 49  ASP B N   1 
ATOM   4318  C CA  . ASP B 1 49  ? 28.193  52.672  -46.119 1.00 69.52  ? 49  ASP B CA  1 
ATOM   4319  C C   . ASP B 1 49  ? 29.078  52.184  -44.976 1.00 69.69  ? 49  ASP B C   1 
ATOM   4320  O O   . ASP B 1 49  ? 28.664  52.214  -43.820 1.00 65.57  ? 49  ASP B O   1 
ATOM   4321  C CB  . ASP B 1 49  ? 27.814  54.139  -45.955 1.00 72.91  ? 49  ASP B CB  1 
ATOM   4322  C CG  . ASP B 1 49  ? 28.922  55.195  -45.944 1.00 81.08  ? 49  ASP B CG  1 
ATOM   4323  O OD1 . ASP B 1 49  ? 30.128  54.844  -45.867 1.00 74.70  ? 49  ASP B OD1 1 
ATOM   4324  O OD2 . ASP B 1 49  ? 28.567  56.398  -45.984 1.00 81.32  ? 49  ASP B OD2 1 
ATOM   4325  N N   . PRO B 1 50  ? 30.333  51.754  -45.265 1.00 88.65  ? 50  PRO B N   1 
ATOM   4326  C CA  . PRO B 1 50  ? 31.216  51.183  -44.239 1.00 84.33  ? 50  PRO B CA  1 
ATOM   4327  C C   . PRO B 1 50  ? 31.636  52.159  -43.144 1.00 74.78  ? 50  PRO B C   1 
ATOM   4328  O O   . PRO B 1 50  ? 32.130  51.742  -42.104 1.00 67.51  ? 50  PRO B O   1 
ATOM   4329  C CB  . PRO B 1 50  ? 32.431  50.687  -45.050 1.00 89.61  ? 50  PRO B CB  1 
ATOM   4330  C CG  . PRO B 1 50  ? 32.447  51.581  -46.277 1.00 92.57  ? 50  PRO B CG  1 
ATOM   4331  C CD  . PRO B 1 50  ? 30.975  51.807  -46.595 1.00 86.53  ? 50  PRO B CD  1 
ATOM   4332  N N   . GLU B 1 51  ? 31.446  53.460  -43.374 1.00 73.46  ? 51  GLU B N   1 
ATOM   4333  C CA  . GLU B 1 51  ? 31.824  54.446  -42.379 1.00 81.21  ? 51  GLU B CA  1 
ATOM   4334  C C   . GLU B 1 51  ? 30.934  54.275  -41.147 1.00 79.50  ? 51  GLU B C   1 
ATOM   4335  O O   . GLU B 1 51  ? 31.385  54.533  -40.034 1.00 71.21  ? 51  GLU B O   1 
ATOM   4336  C CB  . GLU B 1 51  ? 31.758  55.866  -42.953 1.00 89.51  ? 51  GLU B CB  1 
ATOM   4337  C CG  . GLU B 1 51  ? 32.458  56.913  -42.085 1.00 91.29  ? 51  GLU B CG  1 
ATOM   4338  C CD  . GLU B 1 51  ? 32.320  58.359  -42.542 1.00 95.35  ? 51  GLU B CD  1 
ATOM   4339  O OE1 . GLU B 1 51  ? 31.461  58.639  -43.413 1.00 88.32  ? 51  GLU B OE1 1 
ATOM   4340  O OE2 . GLU B 1 51  ? 33.102  59.204  -42.042 1.00 93.73  ? 51  GLU B OE2 1 
ATOM   4341  N N   . HIS B 1 52  ? 29.680  53.829  -41.337 1.00 78.63  ? 52  HIS B N   1 
ATOM   4342  C CA  . HIS B 1 52  ? 28.745  53.711  -40.223 1.00 75.75  ? 52  HIS B CA  1 
ATOM   4343  C C   . HIS B 1 52  ? 28.395  52.255  -39.925 1.00 69.22  ? 52  HIS B C   1 
ATOM   4344  O O   . HIS B 1 52  ? 27.335  51.994  -39.374 1.00 69.35  ? 52  HIS B O   1 
ATOM   4345  C CB  . HIS B 1 52  ? 27.440  54.473  -40.476 1.00 68.41  ? 52  HIS B CB  1 
ATOM   4346  C CG  . HIS B 1 52  ? 27.609  55.821  -41.075 1.00 68.46  ? 52  HIS B CG  1 
ATOM   4347  N ND1 . HIS B 1 52  ? 27.257  56.077  -42.384 1.00 65.56  ? 52  HIS B ND1 1 
ATOM   4348  C CD2 . HIS B 1 52  ? 28.052  56.985  -40.566 1.00 71.53  ? 52  HIS B CD2 1 
ATOM   4349  C CE1 . HIS B 1 52  ? 27.511  57.351  -42.663 1.00 70.46  ? 52  HIS B CE1 1 
ATOM   4350  N NE2 . HIS B 1 52  ? 27.988  57.923  -41.574 1.00 68.29  ? 52  HIS B NE2 1 
ATOM   4351  N N   . GLN B 1 53  ? 29.301  51.323  -40.231 1.00 74.98  ? 53  GLN B N   1 
ATOM   4352  C CA  . GLN B 1 53  ? 29.097  49.908  -39.938 1.00 82.01  ? 53  GLN B CA  1 
ATOM   4353  C C   . GLN B 1 53  ? 28.960  49.625  -38.434 1.00 79.90  ? 53  GLN B C   1 
ATOM   4354  O O   . GLN B 1 53  ? 28.150  48.783  -38.036 1.00 82.00  ? 53  GLN B O   1 
ATOM   4355  C CB  . GLN B 1 53  ? 30.258  49.094  -40.506 1.00 81.40  ? 53  GLN B CB  1 
ATOM   4356  C CG  . GLN B 1 53  ? 30.070  47.588  -40.377 1.00 88.35  ? 53  GLN B CG  1 
ATOM   4357  C CD  . GLN B 1 53  ? 31.220  46.788  -40.947 1.00 82.55  ? 53  GLN B CD  1 
ATOM   4358  O OE1 . GLN B 1 53  ? 31.404  46.702  -42.166 1.00 66.81  ? 53  GLN B OE1 1 
ATOM   4359  N NE2 . GLN B 1 53  ? 31.987  46.167  -40.065 1.00 83.20  ? 53  GLN B NE2 1 
ATOM   4360  N N   . ASP B 1 54  ? 29.768  50.294  -37.598 1.00 74.58  ? 54  ASP B N   1 
ATOM   4361  C CA  . ASP B 1 54  ? 29.740  50.098  -36.152 1.00 71.52  ? 54  ASP B CA  1 
ATOM   4362  C C   . ASP B 1 54  ? 28.336  50.318  -35.577 1.00 71.45  ? 54  ASP B C   1 
ATOM   4363  O O   . ASP B 1 54  ? 27.860  49.497  -34.798 1.00 65.33  ? 54  ASP B O   1 
ATOM   4364  C CB  . ASP B 1 54  ? 30.741  50.990  -35.426 1.00 71.40  ? 54  ASP B CB  1 
ATOM   4365  C CG  . ASP B 1 54  ? 32.190  50.512  -35.368 1.00 83.51  ? 54  ASP B CG  1 
ATOM   4366  O OD1 . ASP B 1 54  ? 32.982  51.147  -34.646 1.00 102.28 ? 54  ASP B OD1 1 
ATOM   4367  O OD2 . ASP B 1 54  ? 32.533  49.517  -36.038 1.00 82.29  ? 54  ASP B OD2 1 
ATOM   4368  N N   . VAL B 1 55  ? 27.686  51.432  -35.954 1.00 76.62  ? 55  VAL B N   1 
ATOM   4369  C CA  . VAL B 1 55  ? 26.454  51.893  -35.317 1.00 74.20  ? 55  VAL B CA  1 
ATOM   4370  C C   . VAL B 1 55  ? 25.212  51.371  -36.055 1.00 59.01  ? 55  VAL B C   1 
ATOM   4371  O O   . VAL B 1 55  ? 24.133  51.347  -35.472 1.00 61.47  ? 55  VAL B O   1 
ATOM   4372  C CB  . VAL B 1 55  ? 26.401  53.438  -35.165 1.00 81.36  ? 55  VAL B CB  1 
ATOM   4373  C CG1 . VAL B 1 55  ? 26.298  54.183  -36.493 1.00 81.09  ? 55  VAL B CG1 1 
ATOM   4374  C CG2 . VAL B 1 55  ? 25.258  53.897  -34.260 1.00 85.43  ? 55  VAL B CG2 1 
ATOM   4375  N N   . LEU B 1 56  ? 25.333  50.969  -37.326 1.00 51.96  ? 56  LEU B N   1 
ATOM   4376  C CA  . LEU B 1 56  ? 24.159  50.698  -38.143 1.00 60.32  ? 56  LEU B CA  1 
ATOM   4377  C C   . LEU B 1 56  ? 23.919  49.204  -38.378 1.00 65.55  ? 56  LEU B C   1 
ATOM   4378  O O   . LEU B 1 56  ? 22.780  48.837  -38.689 1.00 65.63  ? 56  LEU B O   1 
ATOM   4379  C CB  . LEU B 1 56  ? 24.259  51.430  -39.480 1.00 61.44  ? 56  LEU B CB  1 
ATOM   4380  C CG  . LEU B 1 56  ? 24.221  52.956  -39.413 1.00 57.91  ? 56  LEU B CG  1 
ATOM   4381  C CD1 . LEU B 1 56  ? 24.079  53.470  -40.830 1.00 57.99  ? 56  LEU B CD1 1 
ATOM   4382  C CD2 . LEU B 1 56  ? 23.102  53.492  -38.515 1.00 57.76  ? 56  LEU B CD2 1 
ATOM   4383  N N   . THR B 1 57  ? 24.964  48.356  -38.277 1.00 66.61  ? 57  THR B N   1 
ATOM   4384  C CA  . THR B 1 57  ? 24.866  46.971  -38.739 1.00 70.45  ? 57  THR B CA  1 
ATOM   4385  C C   . THR B 1 57  ? 25.363  45.995  -37.671 1.00 67.62  ? 57  THR B C   1 
ATOM   4386  O O   . THR B 1 57  ? 25.983  46.395  -36.686 1.00 64.24  ? 57  THR B O   1 
ATOM   4387  C CB  . THR B 1 57  ? 25.639  46.788  -40.047 1.00 67.29  ? 57  THR B CB  1 
ATOM   4388  O OG1 . THR B 1 57  ? 26.998  46.998  -39.669 1.00 71.19  ? 57  THR B OG1 1 
ATOM   4389  C CG2 . THR B 1 57  ? 25.175  47.725  -41.151 1.00 62.36  ? 57  THR B CG2 1 
ATOM   4390  N N   . PHE B 1 58  ? 25.082  44.705  -37.889 1.00 67.55  ? 58  PHE B N   1 
ATOM   4391  C CA  . PHE B 1 58  ? 25.479  43.666  -36.950 1.00 75.45  ? 58  PHE B CA  1 
ATOM   4392  C C   . PHE B 1 58  ? 25.500  42.302  -37.644 1.00 77.27  ? 58  PHE B C   1 
ATOM   4393  O O   . PHE B 1 58  ? 24.761  42.089  -38.608 1.00 68.69  ? 58  PHE B O   1 
ATOM   4394  C CB  . PHE B 1 58  ? 24.508  43.642  -35.763 1.00 69.91  ? 58  PHE B CB  1 
ATOM   4395  C CG  . PHE B 1 58  ? 23.207  42.890  -36.023 1.00 64.50  ? 58  PHE B CG  1 
ATOM   4396  C CD1 . PHE B 1 58  ? 22.240  43.413  -36.878 1.00 58.92  ? 58  PHE B CD1 1 
ATOM   4397  C CD2 . PHE B 1 58  ? 22.960  41.656  -35.419 1.00 68.54  ? 58  PHE B CD2 1 
ATOM   4398  C CE1 . PHE B 1 58  ? 21.064  42.720  -37.120 1.00 60.69  ? 58  PHE B CE1 1 
ATOM   4399  C CE2 . PHE B 1 58  ? 21.778  40.964  -35.660 1.00 64.91  ? 58  PHE B CE2 1 
ATOM   4400  C CZ  . PHE B 1 58  ? 20.832  41.500  -36.507 1.00 63.27  ? 58  PHE B CZ  1 
ATOM   4401  N N   . VAL B 1 59  ? 26.305  41.376  -37.093 1.00 78.70  ? 59  VAL B N   1 
ATOM   4402  C CA  . VAL B 1 59  ? 26.405  40.011  -37.594 1.00 77.68  ? 59  VAL B CA  1 
ATOM   4403  C C   . VAL B 1 59  ? 25.384  39.117  -36.878 1.00 72.14  ? 59  VAL B C   1 
ATOM   4404  O O   . VAL B 1 59  ? 25.480  38.894  -35.676 1.00 71.03  ? 59  VAL B O   1 
ATOM   4405  C CB  . VAL B 1 59  ? 27.854  39.515  -37.420 1.00 84.64  ? 59  VAL B CB  1 
ATOM   4406  C CG1 . VAL B 1 59  ? 28.079  38.173  -38.115 1.00 86.51  ? 59  VAL B CG1 1 
ATOM   4407  C CG2 . VAL B 1 59  ? 28.868  40.548  -37.912 1.00 81.92  ? 59  VAL B CG2 1 
ATOM   4408  N N   . ASP B 1 60  ? 24.392  38.600  -37.618 1.00 70.87  ? 60  ASP B N   1 
ATOM   4409  C CA  . ASP B 1 60  ? 23.275  37.874  -37.021 1.00 73.89  ? 60  ASP B CA  1 
ATOM   4410  C C   . ASP B 1 60  ? 23.731  36.453  -36.675 1.00 80.56  ? 60  ASP B C   1 
ATOM   4411  O O   . ASP B 1 60  ? 24.856  36.067  -36.988 1.00 72.84  ? 60  ASP B O   1 
ATOM   4412  C CB  . ASP B 1 60  ? 22.046  37.912  -37.925 1.00 71.99  ? 60  ASP B CB  1 
ATOM   4413  C CG  . ASP B 1 60  ? 20.690  37.623  -37.280 1.00 82.19  ? 60  ASP B CG  1 
ATOM   4414  O OD1 . ASP B 1 60  ? 20.652  37.282  -36.069 1.00 88.74  ? 60  ASP B OD1 1 
ATOM   4415  O OD2 . ASP B 1 60  ? 19.664  37.742  -37.991 1.00 72.42  ? 60  ASP B OD2 1 
ATOM   4416  N N   . ASP B 1 61  ? 22.842  35.689  -36.018 1.00 92.79  ? 61  ASP B N   1 
ATOM   4417  C CA  . ASP B 1 61  ? 23.109  34.324  -35.578 1.00 94.97  ? 61  ASP B CA  1 
ATOM   4418  C C   . ASP B 1 61  ? 23.433  33.413  -36.769 1.00 98.40  ? 61  ASP B C   1 
ATOM   4419  O O   . ASP B 1 61  ? 24.315  32.563  -36.675 1.00 102.44 ? 61  ASP B O   1 
ATOM   4420  C CB  . ASP B 1 61  ? 21.937  33.775  -34.775 1.00 88.63  ? 61  ASP B CB  1 
ATOM   4421  C CG  . ASP B 1 61  ? 21.619  34.479  -33.460 1.00 82.90  ? 61  ASP B CG  1 
ATOM   4422  O OD1 . ASP B 1 61  ? 22.457  35.282  -32.999 1.00 77.90  ? 61  ASP B OD1 1 
ATOM   4423  O OD2 . ASP B 1 61  ? 20.530  34.212  -32.902 1.00 75.04  ? 61  ASP B OD2 1 
ATOM   4424  N N   . ASP B 1 62  ? 22.727  33.599  -37.895 1.00 96.97  ? 62  ASP B N   1 
ATOM   4425  C CA  . ASP B 1 62  ? 23.010  32.880  -39.132 1.00 90.19  ? 62  ASP B CA  1 
ATOM   4426  C C   . ASP B 1 62  ? 24.347  33.287  -39.773 1.00 78.71  ? 62  ASP B C   1 
ATOM   4427  O O   . ASP B 1 62  ? 24.641  32.830  -40.870 1.00 77.53  ? 62  ASP B O   1 
ATOM   4428  C CB  . ASP B 1 62  ? 21.877  33.046  -40.138 1.00 89.25  ? 62  ASP B CB  1 
ATOM   4429  C CG  . ASP B 1 62  ? 21.559  34.473  -40.582 1.00 97.65  ? 62  ASP B CG  1 
ATOM   4430  O OD1 . ASP B 1 62  ? 22.497  35.297  -40.707 1.00 100.55 ? 62  ASP B OD1 1 
ATOM   4431  O OD2 . ASP B 1 62  ? 20.371  34.755  -40.837 1.00 77.37  ? 62  ASP B OD2 1 
ATOM   4432  N N   . GLY B 1 63  ? 25.141  34.166  -39.140 1.00 80.13  ? 63  GLY B N   1 
ATOM   4433  C CA  . GLY B 1 63  ? 26.454  34.541  -39.652 1.00 79.83  ? 63  GLY B CA  1 
ATOM   4434  C C   . GLY B 1 63  ? 26.440  35.751  -40.601 1.00 86.39  ? 63  GLY B C   1 
ATOM   4435  O O   . GLY B 1 63  ? 27.513  36.246  -40.948 1.00 93.41  ? 63  GLY B O   1 
ATOM   4436  N N   . VAL B 1 64  ? 25.252  36.243  -41.006 1.00 79.05  ? 64  VAL B N   1 
ATOM   4437  C CA  . VAL B 1 64  ? 25.111  37.258  -42.054 1.00 81.79  ? 64  VAL B CA  1 
ATOM   4438  C C   . VAL B 1 64  ? 25.096  38.677  -41.452 1.00 82.25  ? 64  VAL B C   1 
ATOM   4439  O O   . VAL B 1 64  ? 24.558  38.888  -40.364 1.00 74.78  ? 64  VAL B O   1 
ATOM   4440  C CB  . VAL B 1 64  ? 23.813  36.986  -42.856 1.00 78.26  ? 64  VAL B CB  1 
ATOM   4441  C CG1 . VAL B 1 64  ? 23.538  38.051  -43.914 1.00 69.65  ? 64  VAL B CG1 1 
ATOM   4442  C CG2 . VAL B 1 64  ? 23.788  35.593  -43.486 1.00 74.64  ? 64  VAL B CG2 1 
ATOM   4443  N N   . ARG B 1 65  ? 25.647  39.666  -42.181 1.00 72.07  ? 65  ARG B N   1 
ATOM   4444  C CA  . ARG B 1 65  ? 25.588  41.065  -41.768 1.00 71.13  ? 65  ARG B CA  1 
ATOM   4445  C C   . ARG B 1 65  ? 24.268  41.719  -42.194 1.00 73.31  ? 65  ARG B C   1 
ATOM   4446  O O   . ARG B 1 65  ? 23.925  41.732  -43.380 1.00 69.96  ? 65  ARG B O   1 
ATOM   4447  C CB  . ARG B 1 65  ? 26.748  41.868  -42.361 1.00 75.18  ? 65  ARG B CB  1 
ATOM   4448  C CG  . ARG B 1 65  ? 26.733  43.338  -41.960 1.00 77.90  ? 65  ARG B CG  1 
ATOM   4449  C CD  . ARG B 1 65  ? 28.001  44.073  -42.381 1.00 76.89  ? 65  ARG B CD  1 
ATOM   4450  N NE  . ARG B 1 65  ? 29.181  43.581  -41.663 1.00 76.73  ? 65  ARG B NE  1 
ATOM   4451  C CZ  . ARG B 1 65  ? 29.464  43.764  -40.374 1.00 85.79  ? 65  ARG B CZ  1 
ATOM   4452  N NH1 . ARG B 1 65  ? 28.723  44.540  -39.595 1.00 88.52  ? 65  ARG B NH1 1 
ATOM   4453  N NH2 . ARG B 1 65  ? 30.522  43.171  -39.862 1.00 89.52  ? 65  ARG B NH2 1 
ATOM   4454  N N   . LYS B 1 66  ? 23.551  42.297  -41.211 1.00 76.24  ? 66  LYS B N   1 
ATOM   4455  C CA  . LYS B 1 66  ? 22.231  42.887  -41.418 1.00 71.77  ? 66  LYS B CA  1 
ATOM   4456  C C   . LYS B 1 66  ? 22.137  44.254  -40.733 1.00 68.30  ? 66  LYS B C   1 
ATOM   4457  O O   . LYS B 1 66  ? 23.002  44.614  -39.931 1.00 66.25  ? 66  LYS B O   1 
ATOM   4458  C CB  . LYS B 1 66  ? 21.102  41.997  -40.880 1.00 67.72  ? 66  LYS B CB  1 
ATOM   4459  C CG  . LYS B 1 66  ? 21.283  40.529  -41.183 1.00 69.30  ? 66  LYS B CG  1 
ATOM   4460  C CD  . LYS B 1 66  ? 20.122  39.623  -40.804 1.00 77.62  ? 66  LYS B CD  1 
ATOM   4461  C CE  . LYS B 1 66  ? 20.445  38.205  -41.191 1.00 84.86  ? 66  LYS B CE  1 
ATOM   4462  N NZ  . LYS B 1 66  ? 19.360  37.266  -40.899 1.00 86.90  ? 66  LYS B NZ  1 
ATOM   4463  N N   . SER B 1 67  ? 21.062  44.989  -41.068 1.00 65.14  ? 67  SER B N   1 
ATOM   4464  C CA  . SER B 1 67  ? 20.740  46.285  -40.482 1.00 63.20  ? 67  SER B CA  1 
ATOM   4465  C C   . SER B 1 67  ? 20.248  46.131  -39.038 1.00 55.28  ? 67  SER B C   1 
ATOM   4466  O O   . SER B 1 67  ? 19.599  45.142  -38.705 1.00 50.58  ? 67  SER B O   1 
ATOM   4467  C CB  . SER B 1 67  ? 19.716  47.012  -41.324 1.00 58.13  ? 67  SER B CB  1 
ATOM   4468  O OG  . SER B 1 67  ? 20.234  47.313  -42.614 1.00 62.88  ? 67  SER B OG  1 
ATOM   4469  N N   . MET B 1 68  ? 20.506  47.156  -38.207 1.00 47.05  ? 68  MET B N   1 
ATOM   4470  C CA  . MET B 1 68  ? 20.175  47.110  -36.792 1.00 50.90  ? 68  MET B CA  1 
ATOM   4471  C C   . MET B 1 68  ? 18.666  47.223  -36.568 1.00 49.95  ? 68  MET B C   1 
ATOM   4472  O O   . MET B 1 68  ? 18.179  46.963  -35.463 1.00 49.95  ? 68  MET B O   1 
ATOM   4473  C CB  . MET B 1 68  ? 20.947  48.181  -36.017 1.00 51.26  ? 68  MET B CB  1 
ATOM   4474  C CG  . MET B 1 68  ? 22.386  47.777  -35.724 1.00 59.87  ? 68  MET B CG  1 
ATOM   4475  S SD  . MET B 1 68  ? 22.561  46.700  -34.284 1.00 68.04  ? 68  MET B SD  1 
ATOM   4476  C CE  . MET B 1 68  ? 22.411  47.987  -33.032 1.00 75.22  ? 68  MET B CE  1 
ATOM   4477  N N   . HIS B 1 69  ? 17.910  47.529  -37.627 1.00 46.06  ? 69  HIS B N   1 
ATOM   4478  C CA  . HIS B 1 69  ? 16.467  47.441  -37.529 1.00 49.03  ? 69  HIS B CA  1 
ATOM   4479  C C   . HIS B 1 69  ? 16.000  45.983  -37.379 1.00 51.67  ? 69  HIS B C   1 
ATOM   4480  O O   . HIS B 1 69  ? 14.802  45.764  -37.149 1.00 57.72  ? 69  HIS B O   1 
ATOM   4481  C CB  . HIS B 1 69  ? 15.816  48.290  -38.629 1.00 53.01  ? 69  HIS B CB  1 
ATOM   4482  C CG  . HIS B 1 69  ? 16.123  47.932  -40.048 1.00 56.26  ? 69  HIS B CG  1 
ATOM   4483  N ND1 . HIS B 1 69  ? 16.325  48.912  -41.000 1.00 53.80  ? 69  HIS B ND1 1 
ATOM   4484  C CD2 . HIS B 1 69  ? 16.211  46.746  -40.696 1.00 55.94  ? 69  HIS B CD2 1 
ATOM   4485  C CE1 . HIS B 1 69  ? 16.551  48.331  -42.172 1.00 59.02  ? 69  HIS B CE1 1 
ATOM   4486  N NE2 . HIS B 1 69  ? 16.482  47.013  -42.009 1.00 55.91  ? 69  HIS B NE2 1 
ATOM   4487  N N   . TRP B 1 70  ? 16.921  44.996  -37.487 1.00 48.58  ? 70  TRP B N   1 
ATOM   4488  C CA  . TRP B 1 70  ? 16.609  43.578  -37.252 1.00 53.56  ? 70  TRP B CA  1 
ATOM   4489  C C   . TRP B 1 70  ? 17.242  43.024  -35.969 1.00 52.71  ? 70  TRP B C   1 
ATOM   4490  O O   . TRP B 1 70  ? 17.085  41.837  -35.689 1.00 52.30  ? 70  TRP B O   1 
ATOM   4491  C CB  . TRP B 1 70  ? 17.070  42.696  -38.429 1.00 51.98  ? 70  TRP B CB  1 
ATOM   4492  C CG  . TRP B 1 70  ? 16.428  43.016  -39.754 1.00 46.34  ? 70  TRP B CG  1 
ATOM   4493  C CD1 . TRP B 1 70  ? 17.070  43.254  -40.933 1.00 41.92  ? 70  TRP B CD1 1 
ATOM   4494  C CD2 . TRP B 1 70  ? 15.014  43.114  -40.030 1.00 43.80  ? 70  TRP B CD2 1 
ATOM   4495  N NE1 . TRP B 1 70  ? 16.156  43.497  -41.925 1.00 43.86  ? 70  TRP B NE1 1 
ATOM   4496  C CE2 . TRP B 1 70  ? 14.890  43.420  -41.403 1.00 43.69  ? 70  TRP B CE2 1 
ATOM   4497  C CE3 . TRP B 1 70  ? 13.857  42.975  -39.261 1.00 42.68  ? 70  TRP B CE3 1 
ATOM   4498  C CZ2 . TRP B 1 70  ? 13.650  43.584  -42.014 1.00 47.34  ? 70  TRP B CZ2 1 
ATOM   4499  C CZ3 . TRP B 1 70  ? 12.632  43.116  -39.874 1.00 44.82  ? 70  TRP B CZ3 1 
ATOM   4500  C CH2 . TRP B 1 70  ? 12.528  43.430  -41.227 1.00 47.38  ? 70  TRP B CH2 1 
ATOM   4501  N N   . PHE B 1 71  ? 17.930  43.876  -35.189 1.00 53.97  ? 71  PHE B N   1 
ATOM   4502  C CA  . PHE B 1 71  ? 18.709  43.452  -34.033 1.00 55.70  ? 71  PHE B CA  1 
ATOM   4503  C C   . PHE B 1 71  ? 17.820  43.297  -32.795 1.00 56.40  ? 71  PHE B C   1 
ATOM   4504  O O   . PHE B 1 71  ? 17.307  44.283  -32.274 1.00 54.94  ? 71  PHE B O   1 
ATOM   4505  C CB  . PHE B 1 71  ? 19.827  44.474  -33.792 1.00 55.06  ? 71  PHE B CB  1 
ATOM   4506  C CG  . PHE B 1 71  ? 20.795  44.143  -32.658 1.00 61.35  ? 71  PHE B CG  1 
ATOM   4507  C CD1 . PHE B 1 71  ? 21.780  43.170  -32.816 1.00 66.66  ? 71  PHE B CD1 1 
ATOM   4508  C CD2 . PHE B 1 71  ? 20.751  44.832  -31.448 1.00 58.84  ? 71  PHE B CD2 1 
ATOM   4509  C CE1 . PHE B 1 71  ? 22.683  42.888  -31.796 1.00 64.02  ? 71  PHE B CE1 1 
ATOM   4510  C CE2 . PHE B 1 71  ? 21.649  44.543  -30.425 1.00 61.13  ? 71  PHE B CE2 1 
ATOM   4511  C CZ  . PHE B 1 71  ? 22.620  43.581  -30.602 1.00 61.77  ? 71  PHE B CZ  1 
ATOM   4512  N N   . LEU B 1 72  ? 17.693  42.053  -32.307 1.00 56.80  ? 72  LEU B N   1 
ATOM   4513  C CA  . LEU B 1 72  ? 17.048  41.768  -31.034 1.00 65.19  ? 72  LEU B CA  1 
ATOM   4514  C C   . LEU B 1 72  ? 18.059  41.918  -29.891 1.00 64.67  ? 72  LEU B C   1 
ATOM   4515  O O   . LEU B 1 72  ? 19.071  41.224  -29.866 1.00 59.70  ? 72  LEU B O   1 
ATOM   4516  C CB  . LEU B 1 72  ? 16.490  40.352  -31.147 1.00 68.31  ? 72  LEU B CB  1 
ATOM   4517  C CG  . LEU B 1 72  ? 15.561  40.117  -32.343 1.00 73.96  ? 72  LEU B CG  1 
ATOM   4518  C CD1 . LEU B 1 72  ? 15.270  38.632  -32.544 1.00 73.31  ? 72  LEU B CD1 1 
ATOM   4519  C CD2 . LEU B 1 72  ? 14.270  40.924  -32.194 1.00 66.94  ? 72  LEU B CD2 1 
ATOM   4520  N N   . PRO B 1 73  ? 17.846  42.847  -28.925 1.00 66.14  ? 73  PRO B N   1 
ATOM   4521  C CA  . PRO B 1 73  ? 18.765  43.010  -27.793 1.00 69.32  ? 73  PRO B CA  1 
ATOM   4522  C C   . PRO B 1 73  ? 18.636  41.895  -26.750 1.00 64.86  ? 73  PRO B C   1 
ATOM   4523  O O   . PRO B 1 73  ? 17.527  41.458  -26.431 1.00 61.22  ? 73  PRO B O   1 
ATOM   4524  C CB  . PRO B 1 73  ? 18.368  44.391  -27.233 1.00 66.77  ? 73  PRO B CB  1 
ATOM   4525  C CG  . PRO B 1 73  ? 16.883  44.478  -27.523 1.00 66.75  ? 73  PRO B CG  1 
ATOM   4526  C CD  . PRO B 1 73  ? 16.699  43.767  -28.855 1.00 65.31  ? 73  PRO B CD  1 
ATOM   4527  N N   . ARG B 1 74  ? 19.784  41.426  -26.241 1.00 63.25  ? 74  ARG B N   1 
ATOM   4528  C CA  . ARG B 1 74  ? 19.822  40.301  -25.315 1.00 71.90  ? 74  ARG B CA  1 
ATOM   4529  C C   . ARG B 1 74  ? 20.476  40.731  -24.000 1.00 71.78  ? 74  ARG B C   1 
ATOM   4530  O O   . ARG B 1 74  ? 20.615  39.938  -23.071 1.00 69.43  ? 74  ARG B O   1 
ATOM   4531  C CB  . ARG B 1 74  ? 20.524  39.117  -25.996 1.00 69.31  ? 74  ARG B CB  1 
ATOM   4532  C CG  . ARG B 1 74  ? 19.801  38.589  -27.230 1.00 73.33  ? 74  ARG B CG  1 
ATOM   4533  C CD  . ARG B 1 74  ? 20.412  37.304  -27.754 1.00 76.33  ? 74  ARG B CD  1 
ATOM   4534  N NE  . ARG B 1 74  ? 19.472  36.517  -28.561 1.00 84.99  ? 74  ARG B NE  1 
ATOM   4535  C CZ  . ARG B 1 74  ? 19.690  36.031  -29.791 1.00 88.39  ? 74  ARG B CZ  1 
ATOM   4536  N NH1 . ARG B 1 74  ? 20.719  36.429  -30.525 1.00 85.77  ? 74  ARG B NH1 1 
ATOM   4537  N NH2 . ARG B 1 74  ? 18.855  35.144  -30.304 1.00 84.43  ? 74  ARG B NH2 1 
ATOM   4538  N N   . SER B 1 75  ? 20.792  42.023  -23.912 1.00 65.64  ? 75  SER B N   1 
ATOM   4539  C CA  . SER B 1 75  ? 21.679  42.548  -22.899 1.00 61.26  ? 75  SER B CA  1 
ATOM   4540  C C   . SER B 1 75  ? 21.350  44.015  -22.693 1.00 60.82  ? 75  SER B C   1 
ATOM   4541  O O   . SER B 1 75  ? 20.805  44.644  -23.599 1.00 62.32  ? 75  SER B O   1 
ATOM   4542  C CB  . SER B 1 75  ? 23.100  42.413  -23.326 1.00 59.87  ? 75  SER B CB  1 
ATOM   4543  O OG  . SER B 1 75  ? 23.922  43.059  -22.373 1.00 74.92  ? 75  SER B OG  1 
ATOM   4544  N N   . LYS B 1 76  ? 21.740  44.546  -21.530 1.00 57.53  ? 76  LYS B N   1 
ATOM   4545  C CA  . LYS B 1 76  ? 21.678  45.973  -21.276 1.00 56.38  ? 76  LYS B CA  1 
ATOM   4546  C C   . LYS B 1 76  ? 22.519  46.709  -22.307 1.00 55.28  ? 76  LYS B C   1 
ATOM   4547  O O   . LYS B 1 76  ? 22.103  47.747  -22.821 1.00 54.83  ? 76  LYS B O   1 
ATOM   4548  C CB  . LYS B 1 76  ? 22.195  46.366  -19.890 1.00 56.98  ? 76  LYS B CB  1 
ATOM   4549  C CG  . LYS B 1 76  ? 21.919  47.817  -19.494 1.00 60.75  ? 76  LYS B CG  1 
ATOM   4550  C CD  . LYS B 1 76  ? 22.143  48.122  -18.012 1.00 60.64  ? 76  LYS B CD  1 
ATOM   4551  C CE  . LYS B 1 76  ? 21.177  47.403  -17.097 1.00 63.95  ? 76  LYS B CE  1 
ATOM   4552  N NZ  . LYS B 1 76  ? 21.594  47.448  -15.689 1.00 71.53  ? 76  LYS B NZ  1 
ATOM   4553  N N   . ALA B 1 77  ? 23.727  46.191  -22.563 1.00 61.29  ? 77  ALA B N   1 
ATOM   4554  C CA  . ALA B 1 77  ? 24.645  46.821  -23.506 1.00 59.12  ? 77  ALA B CA  1 
ATOM   4555  C C   . ALA B 1 77  ? 24.020  46.832  -24.907 1.00 58.73  ? 77  ALA B C   1 
ATOM   4556  O O   . ALA B 1 77  ? 24.208  47.772  -25.673 1.00 55.77  ? 77  ALA B O   1 
ATOM   4557  C CB  . ALA B 1 77  ? 25.995  46.115  -23.475 1.00 50.68  ? 77  ALA B CB  1 
ATOM   4558  N N   . ASP B 1 78  ? 23.260  45.780  -25.225 1.00 56.72  ? 78  ASP B N   1 
ATOM   4559  C CA  . ASP B 1 78  ? 22.587  45.666  -26.506 1.00 61.34  ? 78  ASP B CA  1 
ATOM   4560  C C   . ASP B 1 78  ? 21.504  46.740  -26.620 1.00 61.19  ? 78  ASP B C   1 
ATOM   4561  O O   . ASP B 1 78  ? 21.459  47.442  -27.630 1.00 61.68  ? 78  ASP B O   1 
ATOM   4562  C CB  . ASP B 1 78  ? 22.080  44.247  -26.734 1.00 64.95  ? 78  ASP B CB  1 
ATOM   4563  C CG  . ASP B 1 78  ? 23.140  43.206  -27.093 1.00 64.01  ? 78  ASP B CG  1 
ATOM   4564  O OD1 . ASP B 1 78  ? 24.341  43.573  -27.190 1.00 62.95  ? 78  ASP B OD1 1 
ATOM   4565  O OD2 . ASP B 1 78  ? 22.761  42.038  -27.298 1.00 58.52  ? 78  ASP B OD2 1 
ATOM   4566  N N   . ALA B 1 79  ? 20.655  46.863  -25.583 1.00 54.04  ? 79  ALA B N   1 
ATOM   4567  C CA  . ALA B 1 79  ? 19.659  47.928  -25.476 1.00 57.31  ? 79  ALA B CA  1 
ATOM   4568  C C   . ALA B 1 79  ? 20.276  49.319  -25.702 1.00 56.87  ? 79  ALA B C   1 
ATOM   4569  O O   . ALA B 1 79  ? 19.645  50.170  -26.327 1.00 55.65  ? 79  ALA B O   1 
ATOM   4570  C CB  . ALA B 1 79  ? 18.946  47.856  -24.130 1.00 51.52  ? 79  ALA B CB  1 
ATOM   4571  N N   . ALA B 1 80  ? 21.506  49.537  -25.206 1.00 53.11  ? 80  ALA B N   1 
ATOM   4572  C CA  . ALA B 1 80  ? 22.192  50.818  -25.307 1.00 56.57  ? 80  ALA B CA  1 
ATOM   4573  C C   . ALA B 1 80  ? 22.609  51.074  -26.750 1.00 57.40  ? 80  ALA B C   1 
ATOM   4574  O O   . ALA B 1 80  ? 22.514  52.204  -27.234 1.00 56.67  ? 80  ALA B O   1 
ATOM   4575  C CB  . ALA B 1 80  ? 23.406  50.871  -24.379 1.00 53.78  ? 80  ALA B CB  1 
ATOM   4576  N N   . ARG B 1 81  ? 23.090  50.013  -27.408 1.00 60.28  ? 81  ARG B N   1 
ATOM   4577  C CA  . ARG B 1 81  ? 23.541  50.073  -28.790 1.00 55.69  ? 81  ARG B CA  1 
ATOM   4578  C C   . ARG B 1 81  ? 22.341  50.351  -29.698 1.00 56.43  ? 81  ARG B C   1 
ATOM   4579  O O   . ARG B 1 81  ? 22.467  51.034  -30.713 1.00 58.56  ? 81  ARG B O   1 
ATOM   4580  C CB  . ARG B 1 81  ? 24.275  48.750  -29.017 1.00 63.52  ? 81  ARG B CB  1 
ATOM   4581  C CG  . ARG B 1 81  ? 24.871  48.496  -30.390 1.00 74.88  ? 81  ARG B CG  1 
ATOM   4582  C CD  . ARG B 1 81  ? 25.472  47.097  -30.449 1.00 78.40  ? 81  ARG B CD  1 
ATOM   4583  N NE  . ARG B 1 81  ? 25.681  46.650  -31.833 1.00 77.07  ? 81  ARG B NE  1 
ATOM   4584  C CZ  . ARG B 1 81  ? 26.257  45.506  -32.183 1.00 79.42  ? 81  ARG B CZ  1 
ATOM   4585  N NH1 . ARG B 1 81  ? 26.699  44.665  -31.263 1.00 89.06  ? 81  ARG B NH1 1 
ATOM   4586  N NH2 . ARG B 1 81  ? 26.392  45.199  -33.459 1.00 81.84  ? 81  ARG B NH2 1 
ATOM   4587  N N   . ARG B 1 82  ? 21.157  49.857  -29.302 1.00 57.42  ? 82  ARG B N   1 
ATOM   4588  C CA  . ARG B 1 82  ? 19.919  50.131  -30.019 1.00 56.90  ? 82  ARG B CA  1 
ATOM   4589  C C   . ARG B 1 82  ? 19.479  51.577  -29.805 1.00 59.73  ? 82  ARG B C   1 
ATOM   4590  O O   . ARG B 1 82  ? 18.932  52.188  -30.720 1.00 57.13  ? 82  ARG B O   1 
ATOM   4591  C CB  . ARG B 1 82  ? 18.769  49.206  -29.602 1.00 54.83  ? 82  ARG B CB  1 
ATOM   4592  C CG  . ARG B 1 82  ? 18.878  47.797  -30.166 1.00 52.95  ? 82  ARG B CG  1 
ATOM   4593  C CD  . ARG B 1 82  ? 17.569  47.037  -30.055 1.00 52.57  ? 82  ARG B CD  1 
ATOM   4594  N NE  . ARG B 1 82  ? 16.528  47.739  -30.810 1.00 53.73  ? 82  ARG B NE  1 
ATOM   4595  C CZ  . ARG B 1 82  ? 16.478  47.839  -32.131 1.00 61.47  ? 82  ARG B CZ  1 
ATOM   4596  N NH1 . ARG B 1 82  ? 17.137  46.980  -32.899 1.00 60.11  ? 82  ARG B NH1 1 
ATOM   4597  N NH2 . ARG B 1 82  ? 15.704  48.758  -32.677 1.00 62.80  ? 82  ARG B NH2 1 
ATOM   4598  N N   . ARG B 1 83  ? 19.700  52.100  -28.589 1.00 60.93  ? 83  ARG B N   1 
ATOM   4599  C CA  . ARG B 1 83  ? 19.430  53.502  -28.297 1.00 64.51  ? 83  ARG B CA  1 
ATOM   4600  C C   . ARG B 1 83  ? 20.294  54.389  -29.201 1.00 55.92  ? 83  ARG B C   1 
ATOM   4601  O O   . ARG B 1 83  ? 19.763  55.270  -29.871 1.00 48.93  ? 83  ARG B O   1 
ATOM   4602  C CB  . ARG B 1 83  ? 19.572  53.776  -26.791 1.00 65.84  ? 83  ARG B CB  1 
ATOM   4603  C CG  . ARG B 1 83  ? 19.101  55.144  -26.314 1.00 56.56  ? 83  ARG B CG  1 
ATOM   4604  C CD  . ARG B 1 83  ? 18.542  55.079  -24.896 1.00 56.66  ? 83  ARG B CD  1 
ATOM   4605  N NE  . ARG B 1 83  ? 19.549  54.611  -23.937 1.00 57.48  ? 83  ARG B NE  1 
ATOM   4606  C CZ  . ARG B 1 83  ? 20.613  55.284  -23.492 1.00 62.69  ? 83  ARG B CZ  1 
ATOM   4607  N NH1 . ARG B 1 83  ? 20.752  56.577  -23.732 1.00 67.09  ? 83  ARG B NH1 1 
ATOM   4608  N NH2 . ARG B 1 83  ? 21.523  54.665  -22.754 1.00 64.16  ? 83  ARG B NH2 1 
ATOM   4609  N N   . ALA B 1 84  ? 21.606  54.103  -29.291 1.00 58.89  ? 84  ALA B N   1 
ATOM   4610  C CA  . ALA B 1 84  ? 22.491  54.854  -30.179 1.00 55.83  ? 84  ALA B CA  1 
ATOM   4611  C C   . ALA B 1 84  ? 21.986  54.838  -31.619 1.00 53.95  ? 84  ALA B C   1 
ATOM   4612  O O   . ALA B 1 84  ? 22.124  55.836  -32.315 1.00 64.48  ? 84  ALA B O   1 
ATOM   4613  C CB  . ALA B 1 84  ? 23.905  54.342  -30.109 1.00 52.57  ? 84  ALA B CB  1 
ATOM   4614  N N   . TYR B 1 85  ? 21.412  53.709  -32.059 1.00 57.19  ? 85  TYR B N   1 
ATOM   4615  C CA  . TYR B 1 85  ? 20.947  53.543  -33.432 1.00 56.32  ? 85  TYR B CA  1 
ATOM   4616  C C   . TYR B 1 85  ? 19.669  54.338  -33.697 1.00 56.99  ? 85  TYR B C   1 
ATOM   4617  O O   . TYR B 1 85  ? 19.529  54.926  -34.769 1.00 49.10  ? 85  TYR B O   1 
ATOM   4618  C CB  . TYR B 1 85  ? 20.693  52.059  -33.716 1.00 53.52  ? 85  TYR B CB  1 
ATOM   4619  C CG  . TYR B 1 85  ? 20.089  51.686  -35.066 1.00 46.48  ? 85  TYR B CG  1 
ATOM   4620  C CD1 . TYR B 1 85  ? 20.832  51.743  -36.242 1.00 46.32  ? 85  TYR B CD1 1 
ATOM   4621  C CD2 . TYR B 1 85  ? 18.793  51.192  -35.149 1.00 48.27  ? 85  TYR B CD2 1 
ATOM   4622  C CE1 . TYR B 1 85  ? 20.289  51.345  -37.457 1.00 50.18  ? 85  TYR B CE1 1 
ATOM   4623  C CE2 . TYR B 1 85  ? 18.240  50.779  -36.350 1.00 49.96  ? 85  TYR B CE2 1 
ATOM   4624  C CZ  . TYR B 1 85  ? 18.987  50.861  -37.512 1.00 53.73  ? 85  TYR B CZ  1 
ATOM   4625  O OH  . TYR B 1 85  ? 18.408  50.467  -38.687 1.00 54.78  ? 85  TYR B OH  1 
ATOM   4626  N N   . HIS B 1 86  ? 18.708  54.305  -32.762 1.00 56.03  ? 86  HIS B N   1 
ATOM   4627  C CA  . HIS B 1 86  ? 17.514  55.121  -32.937 1.00 56.67  ? 86  HIS B CA  1 
ATOM   4628  C C   . HIS B 1 86  ? 17.930  56.595  -32.910 1.00 55.74  ? 86  HIS B C   1 
ATOM   4629  O O   . HIS B 1 86  ? 17.354  57.402  -33.620 1.00 49.69  ? 86  HIS B O   1 
ATOM   4630  C CB  . HIS B 1 86  ? 16.439  54.847  -31.882 1.00 50.93  ? 86  HIS B CB  1 
ATOM   4631  C CG  . HIS B 1 86  ? 15.791  53.506  -31.919 1.00 58.08  ? 86  HIS B CG  1 
ATOM   4632  N ND1 . HIS B 1 86  ? 14.918  53.104  -32.911 1.00 58.33  ? 86  HIS B ND1 1 
ATOM   4633  C CD2 . HIS B 1 86  ? 15.846  52.485  -31.026 1.00 57.90  ? 86  HIS B CD2 1 
ATOM   4634  C CE1 . HIS B 1 86  ? 14.466  51.885  -32.625 1.00 57.07  ? 86  HIS B CE1 1 
ATOM   4635  N NE2 . HIS B 1 86  ? 15.026  51.483  -31.490 1.00 53.93  ? 86  HIS B NE2 1 
ATOM   4636  N N   . GLU B 1 87  ? 18.971  56.918  -32.133 1.00 55.40  ? 87  GLU B N   1 
ATOM   4637  C CA  . GLU B 1 87  ? 19.414  58.289  -31.937 1.00 63.43  ? 87  GLU B CA  1 
ATOM   4638  C C   . GLU B 1 87  ? 20.092  58.764  -33.222 1.00 59.91  ? 87  GLU B C   1 
ATOM   4639  O O   . GLU B 1 87  ? 19.873  59.894  -33.654 1.00 60.92  ? 87  GLU B O   1 
ATOM   4640  C CB  . GLU B 1 87  ? 20.281  58.390  -30.671 1.00 65.09  ? 87  GLU B CB  1 
ATOM   4641  C CG  . GLU B 1 87  ? 20.173  59.719  -29.920 1.00 69.17  ? 87  GLU B CG  1 
ATOM   4642  C CD  . GLU B 1 87  ? 20.884  59.770  -28.567 1.00 72.62  ? 87  GLU B CD  1 
ATOM   4643  O OE1 . GLU B 1 87  ? 20.230  59.395  -27.575 1.00 66.67  ? 87  GLU B OE1 1 
ATOM   4644  O OE2 . GLU B 1 87  ? 22.083  60.152  -28.482 1.00 73.97  ? 87  GLU B OE2 1 
ATOM   4645  N N   . PHE B 1 88  ? 20.879  57.882  -33.849 1.00 60.96  ? 88  PHE B N   1 
ATOM   4646  C CA  . PHE B 1 88  ? 21.539  58.196  -35.112 1.00 60.90  ? 88  PHE B CA  1 
ATOM   4647  C C   . PHE B 1 88  ? 20.489  58.720  -36.096 1.00 63.26  ? 88  PHE B C   1 
ATOM   4648  O O   . PHE B 1 88  ? 20.689  59.745  -36.746 1.00 56.74  ? 88  PHE B O   1 
ATOM   4649  C CB  . PHE B 1 88  ? 22.257  56.944  -35.645 1.00 58.97  ? 88  PHE B CB  1 
ATOM   4650  C CG  . PHE B 1 88  ? 23.007  57.138  -36.957 1.00 61.68  ? 88  PHE B CG  1 
ATOM   4651  C CD1 . PHE B 1 88  ? 22.329  57.106  -38.181 1.00 57.23  ? 88  PHE B CD1 1 
ATOM   4652  C CD2 . PHE B 1 88  ? 24.383  57.371  -36.971 1.00 60.28  ? 88  PHE B CD2 1 
ATOM   4653  C CE1 . PHE B 1 88  ? 23.006  57.313  -39.378 1.00 55.00  ? 88  PHE B CE1 1 
ATOM   4654  C CE2 . PHE B 1 88  ? 25.051  57.579  -38.175 1.00 59.10  ? 88  PHE B CE2 1 
ATOM   4655  C CZ  . PHE B 1 88  ? 24.363  57.549  -39.373 1.00 53.54  ? 88  PHE B CZ  1 
ATOM   4656  N N   . TRP B 1 89  ? 19.358  58.005  -36.179 1.00 58.07  ? 89  TRP B N   1 
ATOM   4657  C CA  . TRP B 1 89  ? 18.347  58.260  -37.193 1.00 57.83  ? 89  TRP B CA  1 
ATOM   4658  C C   . TRP B 1 89  ? 17.501  59.487  -36.858 1.00 54.32  ? 89  TRP B C   1 
ATOM   4659  O O   . TRP B 1 89  ? 17.088  60.200  -37.771 1.00 49.72  ? 89  TRP B O   1 
ATOM   4660  C CB  . TRP B 1 89  ? 17.489  57.000  -37.433 1.00 55.41  ? 89  TRP B CB  1 
ATOM   4661  C CG  . TRP B 1 89  ? 18.235  55.960  -38.235 1.00 59.64  ? 89  TRP B CG  1 
ATOM   4662  C CD1 . TRP B 1 89  ? 18.602  54.701  -37.848 1.00 57.06  ? 89  TRP B CD1 1 
ATOM   4663  C CD2 . TRP B 1 89  ? 18.817  56.160  -39.544 1.00 52.36  ? 89  TRP B CD2 1 
ATOM   4664  N NE1 . TRP B 1 89  ? 19.320  54.092  -38.841 1.00 57.42  ? 89  TRP B NE1 1 
ATOM   4665  C CE2 . TRP B 1 89  ? 19.480  54.961  -39.889 1.00 56.08  ? 89  TRP B CE2 1 
ATOM   4666  C CE3 . TRP B 1 89  ? 18.820  57.217  -40.458 1.00 50.78  ? 89  TRP B CE3 1 
ATOM   4667  C CZ2 . TRP B 1 89  ? 20.137  54.793  -41.107 1.00 52.05  ? 89  TRP B CZ2 1 
ATOM   4668  C CZ3 . TRP B 1 89  ? 19.497  57.060  -41.648 1.00 53.73  ? 89  TRP B CZ3 1 
ATOM   4669  C CH2 . TRP B 1 89  ? 20.141  55.862  -41.969 1.00 52.28  ? 89  TRP B CH2 1 
ATOM   4670  N N   . PHE B 1 90  ? 17.241  59.729  -35.562 1.00 56.68  ? 90  PHE B N   1 
ATOM   4671  C CA  . PHE B 1 90  ? 16.498  60.915  -35.152 1.00 63.29  ? 90  PHE B CA  1 
ATOM   4672  C C   . PHE B 1 90  ? 17.299  62.154  -35.558 1.00 57.05  ? 90  PHE B C   1 
ATOM   4673  O O   . PHE B 1 90  ? 16.719  63.123  -36.031 1.00 66.43  ? 90  PHE B O   1 
ATOM   4674  C CB  . PHE B 1 90  ? 16.120  60.818  -33.668 1.00 61.43  ? 90  PHE B CB  1 
ATOM   4675  C CG  . PHE B 1 90  ? 15.204  59.647  -33.312 1.00 61.49  ? 90  PHE B CG  1 
ATOM   4676  C CD1 . PHE B 1 90  ? 14.236  59.182  -34.206 1.00 67.42  ? 90  PHE B CD1 1 
ATOM   4677  C CD2 . PHE B 1 90  ? 15.312  59.007  -32.078 1.00 63.85  ? 90  PHE B CD2 1 
ATOM   4678  C CE1 . PHE B 1 90  ? 13.413  58.117  -33.881 1.00 69.63  ? 90  PHE B CE1 1 
ATOM   4679  C CE2 . PHE B 1 90  ? 14.491  57.931  -31.760 1.00 68.14  ? 90  PHE B CE2 1 
ATOM   4680  C CZ  . PHE B 1 90  ? 13.548  57.486  -32.661 1.00 70.04  ? 90  PHE B CZ  1 
ATOM   4681  N N   . ARG B 1 91  ? 18.631  62.054  -35.462 1.00 50.90  ? 91  ARG B N   1 
ATOM   4682  C CA  . ARG B 1 91  ? 19.549  63.148  -35.734 1.00 56.80  ? 91  ARG B CA  1 
ATOM   4683  C C   . ARG B 1 91  ? 19.642  63.397  -37.235 1.00 52.28  ? 91  ARG B C   1 
ATOM   4684  O O   . ARG B 1 91  ? 19.502  64.532  -37.661 1.00 59.26  ? 91  ARG B O   1 
ATOM   4685  C CB  . ARG B 1 91  ? 20.900  62.888  -35.044 1.00 60.18  ? 91  ARG B CB  1 
ATOM   4686  C CG  . ARG B 1 91  ? 20.837  63.110  -33.535 1.00 63.41  ? 91  ARG B CG  1 
ATOM   4687  C CD  . ARG B 1 91  ? 22.135  62.827  -32.778 1.00 69.28  ? 91  ARG B CD  1 
ATOM   4688  N NE  . ARG B 1 91  ? 21.901  62.602  -31.340 1.00 76.81  ? 91  ARG B NE  1 
ATOM   4689  C CZ  . ARG B 1 91  ? 21.715  63.523  -30.379 1.00 73.53  ? 91  ARG B CZ  1 
ATOM   4690  N NH1 . ARG B 1 91  ? 21.927  64.808  -30.611 1.00 70.63  ? 91  ARG B NH1 1 
ATOM   4691  N NH2 . ARG B 1 91  ? 21.365  63.144  -29.163 1.00 62.83  ? 91  ARG B NH2 1 
ATOM   4692  N N   . HIS B 1 92  ? 19.847  62.334  -38.019 1.00 52.74  ? 92  HIS B N   1 
ATOM   4693  C CA  . HIS B 1 92  ? 19.815  62.366  -39.476 1.00 53.95  ? 92  HIS B CA  1 
ATOM   4694  C C   . HIS B 1 92  ? 18.473  62.890  -40.002 1.00 54.12  ? 92  HIS B C   1 
ATOM   4695  O O   . HIS B 1 92  ? 18.424  63.587  -41.017 1.00 53.95  ? 92  HIS B O   1 
ATOM   4696  C CB  . HIS B 1 92  ? 20.120  60.964  -40.036 1.00 57.70  ? 92  HIS B CB  1 
ATOM   4697  C CG  . HIS B 1 92  ? 19.964  60.859  -41.518 1.00 56.50  ? 92  HIS B CG  1 
ATOM   4698  N ND1 . HIS B 1 92  ? 18.767  60.522  -42.123 1.00 57.08  ? 92  HIS B ND1 1 
ATOM   4699  C CD2 . HIS B 1 92  ? 20.834  61.096  -42.509 1.00 58.32  ? 92  HIS B CD2 1 
ATOM   4700  C CE1 . HIS B 1 92  ? 18.924  60.533  -43.445 1.00 62.66  ? 92  HIS B CE1 1 
ATOM   4701  N NE2 . HIS B 1 92  ? 20.173  60.896  -43.702 1.00 62.09  ? 92  HIS B NE2 1 
ATOM   4702  N N   . PHE B 1 93  ? 17.374  62.535  -39.325 1.00 53.09  ? 93  PHE B N   1 
ATOM   4703  C CA  . PHE B 1 93  ? 16.067  63.063  -39.684 1.00 53.01  ? 93  PHE B CA  1 
ATOM   4704  C C   . PHE B 1 93  ? 15.720  64.272  -38.811 1.00 60.19  ? 93  PHE B C   1 
ATOM   4705  O O   . PHE B 1 93  ? 14.538  64.525  -38.554 1.00 64.32  ? 93  PHE B O   1 
ATOM   4706  C CB  . PHE B 1 93  ? 15.030  61.948  -39.560 1.00 53.98  ? 93  PHE B CB  1 
ATOM   4707  C CG  . PHE B 1 93  ? 15.105  60.849  -40.611 1.00 61.40  ? 93  PHE B CG  1 
ATOM   4708  C CD1 . PHE B 1 93  ? 15.216  61.153  -41.967 1.00 54.74  ? 93  PHE B CD1 1 
ATOM   4709  C CD2 . PHE B 1 93  ? 15.055  59.503  -40.235 1.00 64.78  ? 93  PHE B CD2 1 
ATOM   4710  C CE1 . PHE B 1 93  ? 15.248  60.145  -42.920 1.00 59.29  ? 93  PHE B CE1 1 
ATOM   4711  C CE2 . PHE B 1 93  ? 15.103  58.497  -41.193 1.00 66.25  ? 93  PHE B CE2 1 
ATOM   4712  C CZ  . PHE B 1 93  ? 15.202  58.820  -42.535 1.00 62.81  ? 93  PHE B CZ  1 
ATOM   4713  N N   . GLN B 1 94  ? 16.758  64.991  -38.346 1.00 60.63  ? 94  GLN B N   1 
ATOM   4714  C CA  . GLN B 1 94  ? 16.665  66.374  -37.892 1.00 61.61  ? 94  GLN B CA  1 
ATOM   4715  C C   . GLN B 1 94  ? 15.718  66.500  -36.699 1.00 68.64  ? 94  GLN B C   1 
ATOM   4716  O O   . GLN B 1 94  ? 14.706  67.197  -36.778 1.00 78.67  ? 94  GLN B O   1 
ATOM   4717  C CB  . GLN B 1 94  ? 16.285  67.250  -39.089 1.00 59.97  ? 94  GLN B CB  1 
ATOM   4718  C CG  . GLN B 1 94  ? 17.306  67.177  -40.225 1.00 64.50  ? 94  GLN B CG  1 
ATOM   4719  C CD  . GLN B 1 94  ? 17.215  68.334  -41.200 1.00 62.88  ? 94  GLN B CD  1 
ATOM   4720  O OE1 . GLN B 1 94  ? 17.235  69.512  -40.822 1.00 68.63  ? 94  GLN B OE1 1 
ATOM   4721  N NE2 . GLN B 1 94  ? 17.122  68.013  -42.478 1.00 61.94  ? 94  GLN B NE2 1 
ATOM   4722  N N   . GLY B 1 95  ? 16.066  65.817  -35.599 1.00 77.84  ? 95  GLY B N   1 
ATOM   4723  C CA  . GLY B 1 95  ? 15.267  65.810  -34.381 1.00 75.31  ? 95  GLY B CA  1 
ATOM   4724  C C   . GLY B 1 95  ? 14.222  64.697  -34.396 1.00 71.67  ? 95  GLY B C   1 
ATOM   4725  O O   . GLY B 1 95  ? 13.752  64.275  -33.335 1.00 68.05  ? 95  GLY B O   1 
ATOM   4726  N N   . GLY B 1 96  ? 13.881  64.251  -35.619 1.00 68.81  ? 96  GLY B N   1 
ATOM   4727  C CA  . GLY B 1 96  ? 12.946  63.165  -35.867 1.00 66.18  ? 96  GLY B CA  1 
ATOM   4728  C C   . GLY B 1 96  ? 11.730  63.623  -36.675 1.00 63.73  ? 96  GLY B C   1 
ATOM   4729  O O   . GLY B 1 96  ? 10.599  63.273  -36.327 1.00 61.96  ? 96  GLY B O   1 
ATOM   4730  N N   . ILE B 1 97  ? 11.965  64.368  -37.770 1.00 56.70  ? 97  ILE B N   1 
ATOM   4731  C CA  . ILE B 1 97  ? 10.867  64.864  -38.588 1.00 63.75  ? 97  ILE B CA  1 
ATOM   4732  C C   . ILE B 1 97  ? 10.115  63.669  -39.179 1.00 61.52  ? 97  ILE B C   1 
ATOM   4733  O O   . ILE B 1 97  ? 8.904   63.741  -39.378 1.00 56.14  ? 97  ILE B O   1 
ATOM   4734  C CB  . ILE B 1 97  ? 11.340  65.866  -39.665 1.00 68.91  ? 97  ILE B CB  1 
ATOM   4735  C CG1 . ILE B 1 97  ? 12.081  65.193  -40.821 1.00 65.75  ? 97  ILE B CG1 1 
ATOM   4736  C CG2 . ILE B 1 97  ? 12.171  66.984  -39.031 1.00 72.55  ? 97  ILE B CG2 1 
ATOM   4737  C CD1 . ILE B 1 97  ? 12.543  66.147  -41.911 1.00 66.44  ? 97  ILE B CD1 1 
ATOM   4738  N N   . PHE B 1 98  ? 10.842  62.569  -39.435 1.00 58.48  ? 98  PHE B N   1 
ATOM   4739  C CA  . PHE B 1 98  ? 10.245  61.328  -39.898 1.00 57.60  ? 98  PHE B CA  1 
ATOM   4740  C C   . PHE B 1 98  ? 10.343  60.333  -38.758 1.00 54.25  ? 98  PHE B C   1 
ATOM   4741  O O   . PHE B 1 98  ? 11.441  59.999  -38.347 1.00 60.85  ? 98  PHE B O   1 
ATOM   4742  C CB  . PHE B 1 98  ? 10.943  60.846  -41.178 1.00 59.39  ? 98  PHE B CB  1 
ATOM   4743  C CG  . PHE B 1 98  ? 10.884  61.814  -42.360 1.00 51.96  ? 98  PHE B CG  1 
ATOM   4744  C CD1 . PHE B 1 98  ? 9.820   62.704  -42.521 1.00 54.62  ? 98  PHE B CD1 1 
ATOM   4745  C CD2 . PHE B 1 98  ? 11.896  61.828  -43.309 1.00 46.22  ? 98  PHE B CD2 1 
ATOM   4746  C CE1 . PHE B 1 98  ? 9.793   63.596  -43.583 1.00 53.26  ? 98  PHE B CE1 1 
ATOM   4747  C CE2 . PHE B 1 98  ? 11.841  62.688  -44.385 1.00 49.25  ? 98  PHE B CE2 1 
ATOM   4748  C CZ  . PHE B 1 98  ? 10.802  63.580  -44.513 1.00 51.82  ? 98  PHE B CZ  1 
ATOM   4749  N N   . THR B 1 99  ? 9.189   59.901  -38.243 1.00 59.16  ? 99  THR B N   1 
ATOM   4750  C CA  . THR B 1 99  ? 9.126   59.125  -37.010 1.00 66.07  ? 99  THR B CA  1 
ATOM   4751  C C   . THR B 1 99  ? 9.128   57.614  -37.292 1.00 72.90  ? 99  THR B C   1 
ATOM   4752  O O   . THR B 1 99  ? 9.334   56.822  -36.362 1.00 67.52  ? 99  THR B O   1 
ATOM   4753  C CB  . THR B 1 99  ? 7.879   59.535  -36.227 1.00 63.59  ? 99  THR B CB  1 
ATOM   4754  O OG1 . THR B 1 99  ? 6.744   59.263  -37.052 1.00 65.00  ? 99  THR B OG1 1 
ATOM   4755  C CG2 . THR B 1 99  ? 7.916   60.996  -35.821 1.00 65.36  ? 99  THR B CG2 1 
ATOM   4756  N N   . ARG B 1 100 ? 8.944   57.222  -38.572 1.00 60.25  ? 100 ARG B N   1 
ATOM   4757  C CA  . ARG B 1 100 ? 8.568   55.862  -38.928 1.00 56.59  ? 100 ARG B CA  1 
ATOM   4758  C C   . ARG B 1 100 ? 9.309   55.376  -40.174 1.00 48.73  ? 100 ARG B C   1 
ATOM   4759  O O   . ARG B 1 100 ? 8.701   54.866  -41.110 1.00 41.68  ? 100 ARG B O   1 
ATOM   4760  C CB  . ARG B 1 100 ? 7.040   55.781  -39.055 1.00 57.77  ? 100 ARG B CB  1 
ATOM   4761  C CG  . ARG B 1 100 ? 6.329   55.671  -37.709 1.00 65.62  ? 100 ARG B CG  1 
ATOM   4762  C CD  . ARG B 1 100 ? 6.833   54.522  -36.790 1.00 66.77  ? 100 ARG B CD  1 
ATOM   4763  N NE  . ARG B 1 100 ? 6.135   54.438  -35.500 1.00 67.75  ? 100 ARG B NE  1 
ATOM   4764  C CZ  . ARG B 1 100 ? 4.899   53.969  -35.300 1.00 73.80  ? 100 ARG B CZ  1 
ATOM   4765  N NH1 . ARG B 1 100 ? 4.247   53.304  -36.245 1.00 70.70  ? 100 ARG B NH1 1 
ATOM   4766  N NH2 . ARG B 1 100 ? 4.324   54.139  -34.122 1.00 75.89  ? 100 ARG B NH2 1 
ATOM   4767  N N   . PRO B 1 101 ? 10.655  55.447  -40.191 1.00 42.43  ? 101 PRO B N   1 
ATOM   4768  C CA  . PRO B 1 101 ? 11.445  54.648  -41.111 1.00 47.82  ? 101 PRO B CA  1 
ATOM   4769  C C   . PRO B 1 101 ? 11.369  53.191  -40.633 1.00 56.24  ? 101 PRO B C   1 
ATOM   4770  O O   . PRO B 1 101 ? 10.705  52.885  -39.638 1.00 53.25  ? 101 PRO B O   1 
ATOM   4771  C CB  . PRO B 1 101 ? 12.837  55.274  -40.957 1.00 45.23  ? 101 PRO B CB  1 
ATOM   4772  C CG  . PRO B 1 101 ? 12.895  55.699  -39.512 1.00 47.25  ? 101 PRO B CG  1 
ATOM   4773  C CD  . PRO B 1 101 ? 11.492  56.201  -39.240 1.00 49.67  ? 101 PRO B CD  1 
ATOM   4774  N N   . PRO B 1 102 ? 11.983  52.228  -41.354 1.00 53.14  ? 102 PRO B N   1 
ATOM   4775  C CA  . PRO B 1 102 ? 12.063  50.850  -40.854 1.00 58.73  ? 102 PRO B CA  1 
ATOM   4776  C C   . PRO B 1 102 ? 12.568  50.713  -39.413 1.00 55.81  ? 102 PRO B C   1 
ATOM   4777  O O   . PRO B 1 102 ? 12.014  49.938  -38.654 1.00 47.61  ? 102 PRO B O   1 
ATOM   4778  C CB  . PRO B 1 102 ? 12.968  50.187  -41.897 1.00 56.36  ? 102 PRO B CB  1 
ATOM   4779  C CG  . PRO B 1 102 ? 12.648  50.950  -43.184 1.00 54.74  ? 102 PRO B CG  1 
ATOM   4780  C CD  . PRO B 1 102 ? 12.504  52.387  -42.724 1.00 51.75  ? 102 PRO B CD  1 
ATOM   4781  N N   . ALA B 1 103 ? 13.565  51.515  -39.017 1.00 57.96  ? 103 ALA B N   1 
ATOM   4782  C CA  . ALA B 1 103 ? 14.113  51.499  -37.666 1.00 53.24  ? 103 ALA B CA  1 
ATOM   4783  C C   . ALA B 1 103 ? 13.029  51.680  -36.603 1.00 54.53  ? 103 ALA B C   1 
ATOM   4784  O O   . ALA B 1 103 ? 13.140  51.106  -35.522 1.00 60.47  ? 103 ALA B O   1 
ATOM   4785  C CB  . ALA B 1 103 ? 15.154  52.585  -37.517 1.00 50.42  ? 103 ALA B CB  1 
ATOM   4786  N N   . GLY B 1 104 ? 12.034  52.535  -36.888 1.00 53.87  ? 104 GLY B N   1 
ATOM   4787  C CA  . GLY B 1 104 ? 10.986  52.844  -35.931 1.00 51.26  ? 104 GLY B CA  1 
ATOM   4788  C C   . GLY B 1 104 ? 9.834   51.848  -36.024 1.00 54.50  ? 104 GLY B C   1 
ATOM   4789  O O   . GLY B 1 104 ? 9.152   51.592  -35.039 1.00 54.51  ? 104 GLY B O   1 
ATOM   4790  N N   . MET B 1 105 ? 9.636   51.278  -37.216 1.00 55.24  ? 105 MET B N   1 
ATOM   4791  C CA  . MET B 1 105 ? 8.461   50.475  -37.502 1.00 55.24  ? 105 MET B CA  1 
ATOM   4792  C C   . MET B 1 105 ? 8.638   48.996  -37.181 1.00 47.57  ? 105 MET B C   1 
ATOM   4793  O O   . MET B 1 105 ? 7.681   48.338  -36.831 1.00 45.74  ? 105 MET B O   1 
ATOM   4794  C CB  . MET B 1 105 ? 8.134   50.549  -38.987 1.00 58.92  ? 105 MET B CB  1 
ATOM   4795  C CG  . MET B 1 105 ? 7.471   51.849  -39.373 1.00 58.74  ? 105 MET B CG  1 
ATOM   4796  S SD  . MET B 1 105 ? 6.902   51.718  -41.074 1.00 58.04  ? 105 MET B SD  1 
ATOM   4797  C CE  . MET B 1 105 ? 8.509   51.715  -41.881 1.00 55.57  ? 105 MET B CE  1 
ATOM   4798  N N   . HIS B 1 106 ? 9.843   48.463  -37.366 1.00 49.96  ? 106 HIS B N   1 
ATOM   4799  C CA  . HIS B 1 106 ? 10.043  47.024  -37.359 1.00 52.70  ? 106 HIS B CA  1 
ATOM   4800  C C   . HIS B 1 106 ? 10.021  46.508  -35.923 1.00 55.74  ? 106 HIS B C   1 
ATOM   4801  O O   . HIS B 1 106 ? 9.761   45.333  -35.717 1.00 54.60  ? 106 HIS B O   1 
ATOM   4802  C CB  . HIS B 1 106 ? 11.345  46.648  -38.084 1.00 56.68  ? 106 HIS B CB  1 
ATOM   4803  C CG  . HIS B 1 106 ? 11.310  46.820  -39.574 1.00 50.18  ? 106 HIS B CG  1 
ATOM   4804  N ND1 . HIS B 1 106 ? 12.460  46.836  -40.345 1.00 45.86  ? 106 HIS B ND1 1 
ATOM   4805  C CD2 . HIS B 1 106 ? 10.271  46.940  -40.429 1.00 44.81  ? 106 HIS B CD2 1 
ATOM   4806  C CE1 . HIS B 1 106 ? 12.113  46.983  -41.623 1.00 44.45  ? 106 HIS B CE1 1 
ATOM   4807  N NE2 . HIS B 1 106 ? 10.792  47.067  -41.696 1.00 43.13  ? 106 HIS B NE2 1 
ATOM   4808  N N   . VAL B 1 107 ? 10.262  47.404  -34.950 1.00 57.09  ? 107 VAL B N   1 
ATOM   4809  C CA  . VAL B 1 107 ? 10.369  47.038  -33.548 1.00 51.06  ? 107 VAL B CA  1 
ATOM   4810  C C   . VAL B 1 107 ? 9.075   46.362  -33.101 1.00 48.18  ? 107 VAL B C   1 
ATOM   4811  O O   . VAL B 1 107 ? 9.080   45.637  -32.110 1.00 52.12  ? 107 VAL B O   1 
ATOM   4812  C CB  . VAL B 1 107 ? 10.714  48.202  -32.590 1.00 51.56  ? 107 VAL B CB  1 
ATOM   4813  C CG1 . VAL B 1 107 ? 12.042  48.867  -32.949 1.00 46.85  ? 107 VAL B CG1 1 
ATOM   4814  C CG2 . VAL B 1 107 ? 9.577   49.226  -32.465 1.00 48.08  ? 107 VAL B CG2 1 
ATOM   4815  N N   . VAL B 1 108 ? 7.979   46.581  -33.830 1.00 45.57  ? 108 VAL B N   1 
ATOM   4816  C CA  . VAL B 1 108 ? 6.701   46.002  -33.439 1.00 53.79  ? 108 VAL B CA  1 
ATOM   4817  C C   . VAL B 1 108 ? 6.757   44.460  -33.498 1.00 58.47  ? 108 VAL B C   1 
ATOM   4818  O O   . VAL B 1 108 ? 5.970   43.784  -32.837 1.00 55.82  ? 108 VAL B O   1 
ATOM   4819  C CB  . VAL B 1 108 ? 5.572   46.631  -34.295 1.00 56.32  ? 108 VAL B CB  1 
ATOM   4820  C CG1 . VAL B 1 108 ? 5.393   45.946  -35.645 1.00 53.17  ? 108 VAL B CG1 1 
ATOM   4821  C CG2 . VAL B 1 108 ? 4.240   46.665  -33.562 1.00 60.59  ? 108 VAL B CG2 1 
ATOM   4822  N N   . MET B 1 109 ? 7.692   43.877  -34.260 1.00 54.31  ? 109 MET B N   1 
ATOM   4823  C CA  . MET B 1 109 ? 7.750   42.429  -34.408 1.00 62.84  ? 109 MET B CA  1 
ATOM   4824  C C   . MET B 1 109 ? 8.596   41.783  -33.303 1.00 60.60  ? 109 MET B C   1 
ATOM   4825  O O   . MET B 1 109 ? 8.570   40.562  -33.144 1.00 50.30  ? 109 MET B O   1 
ATOM   4826  C CB  . MET B 1 109 ? 8.361   42.005  -35.752 1.00 58.30  ? 109 MET B CB  1 
ATOM   4827  C CG  . MET B 1 109 ? 7.632   42.530  -36.974 1.00 71.39  ? 109 MET B CG  1 
ATOM   4828  S SD  . MET B 1 109 ? 8.491   42.117  -38.509 1.00 71.53  ? 109 MET B SD  1 
ATOM   4829  C CE  . MET B 1 109 ? 8.099   40.359  -38.418 1.00 81.15  ? 109 MET B CE  1 
ATOM   4830  N N   . TYR B 1 110 ? 9.377   42.577  -32.561 1.00 52.43  ? 110 TYR B N   1 
ATOM   4831  C CA  . TYR B 1 110 ? 10.383  42.010  -31.674 1.00 54.78  ? 110 TYR B CA  1 
ATOM   4832  C C   . TYR B 1 110 ? 9.754   41.073  -30.629 1.00 62.64  ? 110 TYR B C   1 
ATOM   4833  O O   . TYR B 1 110 ? 10.355  40.056  -30.267 1.00 54.49  ? 110 TYR B O   1 
ATOM   4834  C CB  . TYR B 1 110 ? 11.215  43.134  -31.043 1.00 56.07  ? 110 TYR B CB  1 
ATOM   4835  C CG  . TYR B 1 110 ? 12.084  43.968  -31.985 1.00 56.23  ? 110 TYR B CG  1 
ATOM   4836  C CD1 . TYR B 1 110 ? 12.197  43.686  -33.344 1.00 51.00  ? 110 TYR B CD1 1 
ATOM   4837  C CD2 . TYR B 1 110 ? 12.841  45.024  -31.491 1.00 59.41  ? 110 TYR B CD2 1 
ATOM   4838  C CE1 . TYR B 1 110 ? 12.995  44.453  -34.180 1.00 52.66  ? 110 TYR B CE1 1 
ATOM   4839  C CE2 . TYR B 1 110 ? 13.659  45.784  -32.314 1.00 59.25  ? 110 TYR B CE2 1 
ATOM   4840  C CZ  . TYR B 1 110 ? 13.728  45.509  -33.669 1.00 54.90  ? 110 TYR B CZ  1 
ATOM   4841  O OH  . TYR B 1 110 ? 14.522  46.273  -34.479 1.00 54.05  ? 110 TYR B OH  1 
ATOM   4842  N N   . ALA B 1 111 ? 8.552   41.399  -30.137 1.00 61.78  ? 111 ALA B N   1 
ATOM   4843  C CA  . ALA B 1 111 ? 7.931   40.598  -29.092 1.00 63.40  ? 111 ALA B CA  1 
ATOM   4844  C C   . ALA B 1 111 ? 7.330   39.314  -29.663 1.00 60.56  ? 111 ALA B C   1 
ATOM   4845  O O   . ALA B 1 111 ? 7.216   38.317  -28.938 1.00 61.08  ? 111 ALA B O   1 
ATOM   4846  C CB  . ALA B 1 111 ? 6.880   41.404  -28.353 1.00 61.54  ? 111 ALA B CB  1 
ATOM   4847  N N   . GLN B 1 112 ? 6.930   39.350  -30.945 1.00 58.68  ? 112 GLN B N   1 
ATOM   4848  C CA  . GLN B 1 112 ? 6.359   38.183  -31.609 1.00 57.12  ? 112 GLN B CA  1 
ATOM   4849  C C   . GLN B 1 112 ? 7.421   37.096  -31.755 1.00 59.35  ? 112 GLN B C   1 
ATOM   4850  O O   . GLN B 1 112 ? 7.192   35.961  -31.349 1.00 56.58  ? 112 GLN B O   1 
ATOM   4851  C CB  . GLN B 1 112 ? 5.813   38.411  -33.014 1.00 53.52  ? 112 GLN B CB  1 
ATOM   4852  C CG  . GLN B 1 112 ? 4.690   39.431  -33.089 1.00 58.24  ? 112 GLN B CG  1 
ATOM   4853  C CD  . GLN B 1 112 ? 4.125   39.550  -34.487 1.00 61.99  ? 112 GLN B CD  1 
ATOM   4854  O OE1 . GLN B 1 112 ? 4.844   39.847  -35.449 1.00 62.21  ? 112 GLN B OE1 1 
ATOM   4855  N NE2 . GLN B 1 112 ? 2.832   39.286  -34.608 1.00 56.82  ? 112 GLN B NE2 1 
ATOM   4856  N N   . ILE B 1 113 ? 8.569   37.454  -32.342 1.00 54.28  ? 113 ILE B N   1 
ATOM   4857  C CA  . ILE B 1 113 ? 9.616   36.488  -32.624 1.00 55.97  ? 113 ILE B CA  1 
ATOM   4858  C C   . ILE B 1 113 ? 10.235  35.972  -31.318 1.00 52.96  ? 113 ILE B C   1 
ATOM   4859  O O   . ILE B 1 113 ? 10.705  34.838  -31.275 1.00 56.12  ? 113 ILE B O   1 
ATOM   4860  C CB  . ILE B 1 113 ? 10.650  37.066  -33.617 1.00 58.07  ? 113 ILE B CB  1 
ATOM   4861  C CG1 . ILE B 1 113 ? 11.709  36.014  -34.025 1.00 60.58  ? 113 ILE B CG1 1 
ATOM   4862  C CG2 . ILE B 1 113 ? 11.309  38.338  -33.082 1.00 59.59  ? 113 ILE B CG2 1 
ATOM   4863  C CD1 . ILE B 1 113 ? 11.153  34.770  -34.714 1.00 60.25  ? 113 ILE B CD1 1 
ATOM   4864  N N   . ASP B 1 114 ? 10.189  36.773  -30.243 1.00 58.57  ? 114 ASP B N   1 
ATOM   4865  C CA  . ASP B 1 114 ? 10.725  36.399  -28.932 1.00 58.38  ? 114 ASP B CA  1 
ATOM   4866  C C   . ASP B 1 114 ? 9.889   35.292  -28.269 1.00 58.53  ? 114 ASP B C   1 
ATOM   4867  O O   . ASP B 1 114 ? 10.405  34.469  -27.518 1.00 50.94  ? 114 ASP B O   1 
ATOM   4868  C CB  . ASP B 1 114 ? 10.811  37.619  -28.023 1.00 53.57  ? 114 ASP B CB  1 
ATOM   4869  C CG  . ASP B 1 114 ? 11.292  37.382  -26.594 1.00 58.84  ? 114 ASP B CG  1 
ATOM   4870  O OD1 . ASP B 1 114 ? 12.463  36.978  -26.409 1.00 53.60  ? 114 ASP B OD1 1 
ATOM   4871  O OD2 . ASP B 1 114 ? 10.501  37.631  -25.662 1.00 60.06  ? 114 ASP B OD2 1 
ATOM   4872  N N   . ASP B 1 115 ? 8.580   35.300  -28.530 1.00 57.88  ? 115 ASP B N   1 
ATOM   4873  C CA  . ASP B 1 115 ? 7.639   34.446  -27.835 1.00 53.95  ? 115 ASP B CA  1 
ATOM   4874  C C   . ASP B 1 115 ? 6.509   34.110  -28.806 1.00 54.81  ? 115 ASP B C   1 
ATOM   4875  O O   . ASP B 1 115 ? 5.379   34.611  -28.668 1.00 49.81  ? 115 ASP B O   1 
ATOM   4876  C CB  . ASP B 1 115 ? 7.154   35.101  -26.552 1.00 58.71  ? 115 ASP B CB  1 
ATOM   4877  C CG  . ASP B 1 115 ? 6.167   34.289  -25.725 1.00 60.56  ? 115 ASP B CG  1 
ATOM   4878  O OD1 . ASP B 1 115 ? 6.115   33.051  -25.905 1.00 60.34  ? 115 ASP B OD1 1 
ATOM   4879  O OD2 . ASP B 1 115 ? 5.433   34.912  -24.931 1.00 65.39  ? 115 ASP B OD2 1 
ATOM   4880  N N   . PRO B 1 116 ? 6.802   33.274  -29.835 1.00 48.60  ? 116 PRO B N   1 
ATOM   4881  C CA  . PRO B 1 116 ? 5.802   32.911  -30.838 1.00 50.49  ? 116 PRO B CA  1 
ATOM   4882  C C   . PRO B 1 116 ? 4.721   31.921  -30.401 1.00 54.62  ? 116 PRO B C   1 
ATOM   4883  O O   . PRO B 1 116 ? 3.631   31.881  -30.986 1.00 54.73  ? 116 PRO B O   1 
ATOM   4884  C CB  . PRO B 1 116 ? 6.640   32.334  -32.003 1.00 47.80  ? 116 PRO B CB  1 
ATOM   4885  C CG  . PRO B 1 116 ? 8.082   32.454  -31.579 1.00 48.26  ? 116 PRO B CG  1 
ATOM   4886  C CD  . PRO B 1 116 ? 8.128   32.707  -30.115 1.00 44.57  ? 116 PRO B CD  1 
ATOM   4887  N N   . GLU B 1 117 ? 5.056   31.066  -29.430 1.00 59.43  ? 117 GLU B N   1 
ATOM   4888  C CA  . GLU B 1 117 ? 4.287   29.845  -29.228 1.00 58.02  ? 117 GLU B CA  1 
ATOM   4889  C C   . GLU B 1 117 ? 2.842   30.214  -28.889 1.00 57.68  ? 117 GLU B C   1 
ATOM   4890  O O   . GLU B 1 117 ? 1.925   29.614  -29.461 1.00 49.34  ? 117 GLU B O   1 
ATOM   4891  C CB  . GLU B 1 117 ? 4.925   28.892  -28.210 1.00 59.37  ? 117 GLU B CB  1 
ATOM   4892  C CG  . GLU B 1 117 ? 6.147   28.134  -28.732 1.00 63.24  ? 117 GLU B CG  1 
ATOM   4893  C CD  . GLU B 1 117 ? 5.873   27.277  -29.968 1.00 69.87  ? 117 GLU B CD  1 
ATOM   4894  O OE1 . GLU B 1 117 ? 4.762   26.680  -30.059 1.00 64.49  ? 117 GLU B OE1 1 
ATOM   4895  O OE2 . GLU B 1 117 ? 6.772   27.203  -30.843 1.00 61.97  ? 117 GLU B OE2 1 
ATOM   4896  N N   . PRO B 1 118 ? 2.605   31.223  -28.000 1.00 54.19  ? 118 PRO B N   1 
ATOM   4897  C CA  . PRO B 1 118 ? 1.251   31.611  -27.591 1.00 51.19  ? 118 PRO B CA  1 
ATOM   4898  C C   . PRO B 1 118 ? 0.383   32.086  -28.751 1.00 55.35  ? 118 PRO B C   1 
ATOM   4899  O O   . PRO B 1 118 ? -0.826  31.855  -28.754 1.00 58.55  ? 118 PRO B O   1 
ATOM   4900  C CB  . PRO B 1 118 ? 1.461   32.728  -26.550 1.00 50.99  ? 118 PRO B CB  1 
ATOM   4901  C CG  . PRO B 1 118 ? 2.884   32.562  -26.098 1.00 51.15  ? 118 PRO B CG  1 
ATOM   4902  C CD  . PRO B 1 118 ? 3.629   32.019  -27.307 1.00 52.60  ? 118 PRO B CD  1 
ATOM   4903  N N   . TRP B 1 119 ? 1.003   32.768  -29.724 1.00 55.50  ? 119 TRP B N   1 
ATOM   4904  C CA  . TRP B 1 119 ? 0.275   33.210  -30.902 1.00 56.68  ? 119 TRP B CA  1 
ATOM   4905  C C   . TRP B 1 119 ? -0.419  32.007  -31.544 1.00 57.76  ? 119 TRP B C   1 
ATOM   4906  O O   . TRP B 1 119 ? -1.579  32.108  -31.954 1.00 60.63  ? 119 TRP B O   1 
ATOM   4907  C CB  . TRP B 1 119 ? 1.211   33.966  -31.858 1.00 57.08  ? 119 TRP B CB  1 
ATOM   4908  C CG  . TRP B 1 119 ? 1.731   35.252  -31.266 1.00 59.69  ? 119 TRP B CG  1 
ATOM   4909  C CD1 . TRP B 1 119 ? 2.758   35.401  -30.378 1.00 62.96  ? 119 TRP B CD1 1 
ATOM   4910  C CD2 . TRP B 1 119 ? 1.208   36.583  -31.490 1.00 63.09  ? 119 TRP B CD2 1 
ATOM   4911  N NE1 . TRP B 1 119 ? 2.919   36.723  -30.039 1.00 55.58  ? 119 TRP B NE1 1 
ATOM   4912  C CE2 . TRP B 1 119 ? 1.982   37.471  -30.701 1.00 60.55  ? 119 TRP B CE2 1 
ATOM   4913  C CE3 . TRP B 1 119 ? 0.167   37.104  -32.273 1.00 65.46  ? 119 TRP B CE3 1 
ATOM   4914  C CZ2 . TRP B 1 119 ? 1.746   38.847  -30.682 1.00 59.94  ? 119 TRP B CZ2 1 
ATOM   4915  C CZ3 . TRP B 1 119 ? -0.069  38.462  -32.248 1.00 62.16  ? 119 TRP B CZ3 1 
ATOM   4916  C CH2 . TRP B 1 119 ? 0.708   39.316  -31.460 1.00 59.45  ? 119 TRP B CH2 1 
ATOM   4917  N N   . GLY B 1 120 ? 0.266   30.851  -31.564 1.00 57.96  ? 120 GLY B N   1 
ATOM   4918  C CA  . GLY B 1 120 ? -0.334  29.597  -32.017 1.00 54.42  ? 120 GLY B CA  1 
ATOM   4919  C C   . GLY B 1 120 ? -1.234  28.964  -30.952 1.00 52.40  ? 120 GLY B C   1 
ATOM   4920  O O   . GLY B 1 120 ? -2.398  28.648  -31.208 1.00 47.55  ? 120 GLY B O   1 
ATOM   4921  N N   . ASP B 1 121 ? -0.686  28.809  -29.740 1.00 54.77  ? 121 ASP B N   1 
ATOM   4922  C CA  . ASP B 1 121 ? -1.388  28.163  -28.640 1.00 53.38  ? 121 ASP B CA  1 
ATOM   4923  C C   . ASP B 1 121 ? -2.773  28.787  -28.442 1.00 59.81  ? 121 ASP B C   1 
ATOM   4924  O O   . ASP B 1 121 ? -3.723  28.046  -28.245 1.00 56.56  ? 121 ASP B O   1 
ATOM   4925  C CB  . ASP B 1 121 ? -0.557  28.183  -27.364 1.00 56.24  ? 121 ASP B CB  1 
ATOM   4926  C CG  . ASP B 1 121 ? 0.772   27.433  -27.390 1.00 55.58  ? 121 ASP B CG  1 
ATOM   4927  O OD1 . ASP B 1 121 ? 1.009   26.646  -28.337 1.00 56.33  ? 121 ASP B OD1 1 
ATOM   4928  O OD2 . ASP B 1 121 ? 1.568   27.642  -26.455 1.00 59.57  ? 121 ASP B OD2 1 
ATOM   4929  N N   . ASN B 1 122 ? -2.897  30.129  -28.541 1.00 67.94  ? 122 ASN B N   1 
ATOM   4930  C CA  . ASN B 1 122 ? -4.124  30.850  -28.204 1.00 61.15  ? 122 ASN B CA  1 
ATOM   4931  C C   . ASN B 1 122 ? -5.104  30.949  -29.377 1.00 58.28  ? 122 ASN B C   1 
ATOM   4932  O O   . ASN B 1 122 ? -6.254  31.326  -29.181 1.00 62.27  ? 122 ASN B O   1 
ATOM   4933  C CB  . ASN B 1 122 ? -3.831  32.266  -27.723 1.00 62.53  ? 122 ASN B CB  1 
ATOM   4934  C CG  . ASN B 1 122 ? -3.041  32.290  -26.433 1.00 66.05  ? 122 ASN B CG  1 
ATOM   4935  O OD1 . ASN B 1 122 ? -2.790  31.247  -25.815 1.00 59.02  ? 122 ASN B OD1 1 
ATOM   4936  N ND2 . ASN B 1 122 ? -2.662  33.484  -25.995 1.00 62.43  ? 122 ASN B ND2 1 
ATOM   4937  N N   . ALA B 1 123 ? -4.678  30.590  -30.591 1.00 59.35  ? 123 ALA B N   1 
ATOM   4938  C CA  . ALA B 1 123 ? -5.483  30.812  -31.788 1.00 64.14  ? 123 ALA B CA  1 
ATOM   4939  C C   . ALA B 1 123 ? -6.793  30.005  -31.802 1.00 62.38  ? 123 ALA B C   1 
ATOM   4940  O O   . ALA B 1 123 ? -6.891  28.939  -31.204 1.00 58.41  ? 123 ALA B O   1 
ATOM   4941  C CB  . ALA B 1 123 ? -4.625  30.502  -33.008 1.00 69.58  ? 123 ALA B CB  1 
ATOM   4942  N N   . VAL B 1 124 ? -7.801  30.522  -32.527 1.00 61.33  ? 124 VAL B N   1 
ATOM   4943  C CA  . VAL B 1 124 ? -9.068  29.843  -32.768 1.00 55.07  ? 124 VAL B CA  1 
ATOM   4944  C C   . VAL B 1 124 ? -9.308  29.796  -34.279 1.00 59.90  ? 124 VAL B C   1 
ATOM   4945  O O   . VAL B 1 124 ? -9.472  30.829  -34.932 1.00 63.11  ? 124 VAL B O   1 
ATOM   4946  C CB  . VAL B 1 124 ? -10.274 30.492  -32.058 1.00 55.04  ? 124 VAL B CB  1 
ATOM   4947  C CG1 . VAL B 1 124 ? -11.500 29.602  -32.150 1.00 61.80  ? 124 VAL B CG1 1 
ATOM   4948  C CG2 . VAL B 1 124 ? -10.007 30.826  -30.599 1.00 54.71  ? 124 VAL B CG2 1 
ATOM   4949  N N   . VAL B 1 125 ? -9.350  28.570  -34.816 1.00 61.48  ? 125 VAL B N   1 
ATOM   4950  C CA  . VAL B 1 125 ? -9.374  28.303  -36.244 1.00 57.53  ? 125 VAL B CA  1 
ATOM   4951  C C   . VAL B 1 125 ? -10.641 27.514  -36.575 1.00 56.57  ? 125 VAL B C   1 
ATOM   4952  O O   . VAL B 1 125 ? -11.227 26.873  -35.715 1.00 58.71  ? 125 VAL B O   1 
ATOM   4953  C CB  . VAL B 1 125 ? -8.092  27.531  -36.616 1.00 57.61  ? 125 VAL B CB  1 
ATOM   4954  C CG1 . VAL B 1 125 ? -7.999  27.251  -38.114 1.00 56.74  ? 125 VAL B CG1 1 
ATOM   4955  C CG2 . VAL B 1 125 ? -6.837  28.243  -36.119 1.00 55.00  ? 125 VAL B CG2 1 
ATOM   4956  N N   . ALA B 1 126 ? -11.095 27.583  -37.824 1.00 60.52  ? 126 ALA B N   1 
ATOM   4957  C CA  . ALA B 1 126 ? -12.333 26.921  -38.195 1.00 63.89  ? 126 ALA B CA  1 
ATOM   4958  C C   . ALA B 1 126 ? -12.025 25.593  -38.892 1.00 69.03  ? 126 ALA B C   1 
ATOM   4959  O O   . ALA B 1 126 ? -10.993 25.464  -39.550 1.00 70.67  ? 126 ALA B O   1 
ATOM   4960  C CB  . ALA B 1 126 ? -13.152 27.840  -39.070 1.00 55.88  ? 126 ALA B CB  1 
ATOM   4961  N N   . GLY B 1 127 ? -12.922 24.612  -38.710 1.00 70.67  ? 127 GLY B N   1 
ATOM   4962  C CA  . GLY B 1 127 ? -13.013 23.438  -39.572 1.00 72.96  ? 127 GLY B CA  1 
ATOM   4963  C C   . GLY B 1 127 ? -11.914 22.404  -39.312 1.00 69.19  ? 127 GLY B C   1 
ATOM   4964  O O   . GLY B 1 127 ? -11.562 21.624  -40.197 1.00 71.37  ? 127 GLY B O   1 
ATOM   4965  N N   . GLY B 1 128 ? -11.344 22.423  -38.104 1.00 58.72  ? 128 GLY B N   1 
ATOM   4966  C CA  . GLY B 1 128 ? -10.292 21.497  -37.738 1.00 58.78  ? 128 GLY B CA  1 
ATOM   4967  C C   . GLY B 1 128 ? -8.997  21.713  -38.520 1.00 63.39  ? 128 GLY B C   1 
ATOM   4968  O O   . GLY B 1 128 ? -8.110  20.870  -38.487 1.00 72.81  ? 128 GLY B O   1 
ATOM   4969  N N   . ARG B 1 129 ? -8.848  22.838  -39.219 1.00 66.29  ? 129 ARG B N   1 
ATOM   4970  C CA  . ARG B 1 129 ? -7.560  23.112  -39.832 1.00 64.15  ? 129 ARG B CA  1 
ATOM   4971  C C   . ARG B 1 129 ? -6.576  23.330  -38.691 1.00 59.75  ? 129 ARG B C   1 
ATOM   4972  O O   . ARG B 1 129 ? -6.951  23.949  -37.698 1.00 61.42  ? 129 ARG B O   1 
ATOM   4973  C CB  . ARG B 1 129 ? -7.620  24.321  -40.769 1.00 62.42  ? 129 ARG B CB  1 
ATOM   4974  C CG  . ARG B 1 129 ? -8.719  24.195  -41.813 1.00 61.29  ? 129 ARG B CG  1 
ATOM   4975  C CD  . ARG B 1 129 ? -8.433  25.046  -43.034 1.00 60.74  ? 129 ARG B CD  1 
ATOM   4976  N NE  . ARG B 1 129 ? -9.349  24.742  -44.135 1.00 58.53  ? 129 ARG B NE  1 
ATOM   4977  C CZ  . ARG B 1 129 ? -10.647 25.010  -44.118 1.00 64.52  ? 129 ARG B CZ  1 
ATOM   4978  N NH1 . ARG B 1 129 ? -11.186 25.609  -43.063 1.00 59.35  ? 129 ARG B NH1 1 
ATOM   4979  N NH2 . ARG B 1 129 ? -11.392 24.673  -45.162 1.00 61.72  ? 129 ARG B NH2 1 
ATOM   4980  N N   . THR B 1 130 ? -5.373  22.753  -38.802 1.00 57.28  ? 130 THR B N   1 
ATOM   4981  C CA  . THR B 1 130 ? -4.289  23.089  -37.886 1.00 70.79  ? 130 THR B CA  1 
ATOM   4982  C C   . THR B 1 130 ? -3.204  23.832  -38.662 1.00 67.72  ? 130 THR B C   1 
ATOM   4983  O O   . THR B 1 130 ? -2.639  23.335  -39.637 1.00 62.16  ? 130 THR B O   1 
ATOM   4984  C CB  . THR B 1 130 ? -3.719  21.887  -37.121 1.00 75.07  ? 130 THR B CB  1 
ATOM   4985  O OG1 . THR B 1 130 ? -3.645  20.778  -38.012 1.00 65.90  ? 130 THR B OG1 1 
ATOM   4986  C CG2 . THR B 1 130 ? -4.550  21.549  -35.895 1.00 77.67  ? 130 THR B CG2 1 
ATOM   4987  N N   . ILE B 1 131 ? -2.926  25.049  -38.192 1.00 69.42  ? 131 ILE B N   1 
ATOM   4988  C CA  . ILE B 1 131 ? -1.984  25.937  -38.837 1.00 62.82  ? 131 ILE B CA  1 
ATOM   4989  C C   . ILE B 1 131 ? -0.835  26.116  -37.854 1.00 56.47  ? 131 ILE B C   1 
ATOM   4990  O O   . ILE B 1 131 ? -1.071  26.246  -36.652 1.00 49.11  ? 131 ILE B O   1 
ATOM   4991  C CB  . ILE B 1 131 ? -2.693  27.249  -39.236 1.00 66.47  ? 131 ILE B CB  1 
ATOM   4992  C CG1 . ILE B 1 131 ? -3.984  26.978  -40.028 1.00 70.77  ? 131 ILE B CG1 1 
ATOM   4993  C CG2 . ILE B 1 131 ? -1.757  28.190  -39.993 1.00 69.51  ? 131 ILE B CG2 1 
ATOM   4994  C CD1 . ILE B 1 131 ? -3.782  26.202  -41.324 1.00 68.15  ? 131 ILE B CD1 1 
ATOM   4995  N N   . SER B 1 132 ? 0.401   26.067  -38.368 1.00 53.46  ? 132 SER B N   1 
ATOM   4996  C CA  . SER B 1 132 ? 1.572   26.205  -37.524 1.00 59.93  ? 132 SER B CA  1 
ATOM   4997  C C   . SER B 1 132 ? 1.936   27.681  -37.348 1.00 59.34  ? 132 SER B C   1 
ATOM   4998  O O   . SER B 1 132 ? 2.917   28.160  -37.910 1.00 59.56  ? 132 SER B O   1 
ATOM   4999  C CB  . SER B 1 132 ? 2.710   25.416  -38.094 1.00 64.24  ? 132 SER B CB  1 
ATOM   5000  O OG  . SER B 1 132 ? 2.449   24.025  -37.989 1.00 72.83  ? 132 SER B OG  1 
ATOM   5001  N N   . PHE B 1 133 ? 1.172   28.394  -36.517 1.00 56.10  ? 133 PHE B N   1 
ATOM   5002  C CA  . PHE B 1 133 ? 1.335   29.837  -36.379 1.00 58.52  ? 133 PHE B CA  1 
ATOM   5003  C C   . PHE B 1 133 ? 2.745   30.203  -35.921 1.00 50.98  ? 133 PHE B C   1 
ATOM   5004  O O   . PHE B 1 133 ? 3.366   31.096  -36.498 1.00 53.20  ? 133 PHE B O   1 
ATOM   5005  C CB  . PHE B 1 133 ? 0.241   30.382  -35.460 1.00 57.27  ? 133 PHE B CB  1 
ATOM   5006  C CG  . PHE B 1 133 ? -1.142  30.331  -36.099 1.00 60.05  ? 133 PHE B CG  1 
ATOM   5007  C CD1 . PHE B 1 133 ? -1.430  31.087  -37.234 1.00 59.41  ? 133 PHE B CD1 1 
ATOM   5008  C CD2 . PHE B 1 133 ? -2.159  29.556  -35.550 1.00 58.02  ? 133 PHE B CD2 1 
ATOM   5009  C CE1 . PHE B 1 133 ? -2.697  31.049  -37.811 1.00 60.04  ? 133 PHE B CE1 1 
ATOM   5010  C CE2 . PHE B 1 133 ? -3.424  29.534  -36.122 1.00 54.29  ? 133 PHE B CE2 1 
ATOM   5011  C CZ  . PHE B 1 133 ? -3.688  30.276  -37.253 1.00 57.58  ? 133 PHE B CZ  1 
ATOM   5012  N N   . ALA B 1 134 ? 3.259   29.510  -34.905 1.00 49.65  ? 134 ALA B N   1 
ATOM   5013  C CA  . ALA B 1 134 ? 4.594   29.788  -34.394 1.00 53.73  ? 134 ALA B CA  1 
ATOM   5014  C C   . ALA B 1 134 ? 5.660   29.609  -35.474 1.00 57.50  ? 134 ALA B C   1 
ATOM   5015  O O   . ALA B 1 134 ? 6.590   30.424  -35.573 1.00 52.56  ? 134 ALA B O   1 
ATOM   5016  C CB  . ALA B 1 134 ? 4.887   28.922  -33.188 1.00 51.95  ? 134 ALA B CB  1 
ATOM   5017  N N   . ASP B 1 135 ? 5.530   28.537  -36.277 1.00 63.29  ? 135 ASP B N   1 
ATOM   5018  C CA  . ASP B 1 135 ? 6.452   28.304  -37.384 1.00 63.02  ? 135 ASP B CA  1 
ATOM   5019  C C   . ASP B 1 135 ? 6.332   29.464  -38.372 1.00 61.06  ? 135 ASP B C   1 
ATOM   5020  O O   . ASP B 1 135 ? 7.332   29.975  -38.879 1.00 55.56  ? 135 ASP B O   1 
ATOM   5021  C CB  . ASP B 1 135 ? 6.218   26.963  -38.067 1.00 64.81  ? 135 ASP B CB  1 
ATOM   5022  C CG  . ASP B 1 135 ? 6.615   25.717  -37.284 1.00 70.88  ? 135 ASP B CG  1 
ATOM   5023  O OD1 . ASP B 1 135 ? 7.507   25.812  -36.413 1.00 69.69  ? 135 ASP B OD1 1 
ATOM   5024  O OD2 . ASP B 1 135 ? 6.007   24.657  -37.542 1.00 78.30  ? 135 ASP B OD2 1 
ATOM   5025  N N   . ASN B 1 136 ? 5.086   29.877  -38.625 1.00 55.60  ? 136 ASN B N   1 
ATOM   5026  C CA  . ASN B 1 136 ? 4.817   31.019  -39.481 1.00 59.64  ? 136 ASN B CA  1 
ATOM   5027  C C   . ASN B 1 136 ? 5.643   32.229  -39.032 1.00 60.03  ? 136 ASN B C   1 
ATOM   5028  O O   . ASN B 1 136 ? 6.277   32.873  -39.869 1.00 56.28  ? 136 ASN B O   1 
ATOM   5029  C CB  . ASN B 1 136 ? 3.319   31.285  -39.580 1.00 51.65  ? 136 ASN B CB  1 
ATOM   5030  C CG  . ASN B 1 136 ? 2.615   30.240  -40.413 1.00 52.34  ? 136 ASN B CG  1 
ATOM   5031  O OD1 . ASN B 1 136 ? 3.279   29.409  -41.039 1.00 57.62  ? 136 ASN B OD1 1 
ATOM   5032  N ND2 . ASN B 1 136 ? 1.287   30.266  -40.454 1.00 55.25  ? 136 ASN B ND2 1 
ATOM   5033  N N   . ILE B 1 137 ? 5.675   32.502  -37.720 1.00 56.79  ? 137 ILE B N   1 
ATOM   5034  C CA  . ILE B 1 137 ? 6.358   33.673  -37.191 1.00 52.93  ? 137 ILE B CA  1 
ATOM   5035  C C   . ILE B 1 137 ? 7.863   33.520  -37.395 1.00 52.89  ? 137 ILE B C   1 
ATOM   5036  O O   . ILE B 1 137 ? 8.537   34.456  -37.843 1.00 54.79  ? 137 ILE B O   1 
ATOM   5037  C CB  . ILE B 1 137 ? 5.954   33.919  -35.721 1.00 51.74  ? 137 ILE B CB  1 
ATOM   5038  C CG1 . ILE B 1 137 ? 4.492   34.390  -35.637 1.00 48.92  ? 137 ILE B CG1 1 
ATOM   5039  C CG2 . ILE B 1 137 ? 6.897   34.897  -35.016 1.00 50.08  ? 137 ILE B CG2 1 
ATOM   5040  C CD1 . ILE B 1 137 ? 3.932   34.414  -34.226 1.00 47.83  ? 137 ILE B CD1 1 
ATOM   5041  N N   . ARG B 1 138 ? 8.384   32.329  -37.098 1.00 53.88  ? 138 ARG B N   1 
ATOM   5042  C CA  . ARG B 1 138 ? 9.820   32.106  -37.193 1.00 56.21  ? 138 ARG B CA  1 
ATOM   5043  C C   . ARG B 1 138 ? 10.277  32.332  -38.635 1.00 53.91  ? 138 ARG B C   1 
ATOM   5044  O O   . ARG B 1 138 ? 11.315  32.950  -38.872 1.00 51.88  ? 138 ARG B O   1 
ATOM   5045  C CB  . ARG B 1 138 ? 10.238  30.739  -36.626 1.00 54.82  ? 138 ARG B CB  1 
ATOM   5046  C CG  . ARG B 1 138 ? 10.570  30.847  -35.145 1.00 59.34  ? 138 ARG B CG  1 
ATOM   5047  C CD  . ARG B 1 138 ? 10.954  29.564  -34.434 1.00 59.71  ? 138 ARG B CD  1 
ATOM   5048  N NE  . ARG B 1 138 ? 9.804   28.659  -34.412 1.00 62.31  ? 138 ARG B NE  1 
ATOM   5049  C CZ  . ARG B 1 138 ? 8.971   28.426  -33.400 1.00 61.94  ? 138 ARG B CZ  1 
ATOM   5050  N NH1 . ARG B 1 138 ? 9.185   28.904  -32.185 1.00 60.75  ? 138 ARG B NH1 1 
ATOM   5051  N NH2 . ARG B 1 138 ? 7.881   27.719  -33.635 1.00 61.35  ? 138 ARG B NH2 1 
ATOM   5052  N N   . SER B 1 139 ? 9.501   31.835  -39.600 1.00 49.15  ? 139 SER B N   1 
ATOM   5053  C CA  . SER B 1 139 ? 9.966   31.829  -40.979 1.00 55.40  ? 139 SER B CA  1 
ATOM   5054  C C   . SER B 1 139 ? 9.646   33.173  -41.641 1.00 56.99  ? 139 SER B C   1 
ATOM   5055  O O   . SER B 1 139 ? 10.405  33.622  -42.503 1.00 55.43  ? 139 SER B O   1 
ATOM   5056  C CB  . SER B 1 139 ? 9.445   30.626  -41.756 1.00 56.04  ? 139 SER B CB  1 
ATOM   5057  O OG  . SER B 1 139 ? 8.044   30.700  -41.964 1.00 63.34  ? 139 SER B OG  1 
ATOM   5058  N N   . GLN B 1 140 ? 8.566   33.842  -41.197 1.00 54.92  ? 140 GLN B N   1 
ATOM   5059  C CA  . GLN B 1 140 ? 8.360   35.257  -41.505 1.00 58.77  ? 140 GLN B CA  1 
ATOM   5060  C C   . GLN B 1 140 ? 9.615   36.040  -41.104 1.00 53.35  ? 140 GLN B C   1 
ATOM   5061  O O   . GLN B 1 140 ? 10.210  36.734  -41.931 1.00 47.89  ? 140 GLN B O   1 
ATOM   5062  C CB  . GLN B 1 140 ? 7.076   35.807  -40.877 1.00 59.83  ? 140 GLN B CB  1 
ATOM   5063  C CG  . GLN B 1 140 ? 5.787   35.217  -41.458 1.00 59.92  ? 140 GLN B CG  1 
ATOM   5064  C CD  . GLN B 1 140 ? 4.555   35.505  -40.622 1.00 61.20  ? 140 GLN B CD  1 
ATOM   5065  O OE1 . GLN B 1 140 ? 4.573   36.350  -39.724 1.00 65.23  ? 140 GLN B OE1 1 
ATOM   5066  N NE2 . GLN B 1 140 ? 3.454   34.830  -40.914 1.00 60.30  ? 140 GLN B NE2 1 
ATOM   5067  N N   . TRP B 1 141 ? 10.080  35.839  -39.866 1.00 55.10  ? 141 TRP B N   1 
ATOM   5068  C CA  . TRP B 1 141 ? 11.262  36.535  -39.368 1.00 56.36  ? 141 TRP B CA  1 
ATOM   5069  C C   . TRP B 1 141 ? 12.500  36.277  -40.236 1.00 59.91  ? 141 TRP B C   1 
ATOM   5070  O O   . TRP B 1 141 ? 13.254  37.204  -40.536 1.00 55.05  ? 141 TRP B O   1 
ATOM   5071  C CB  . TRP B 1 141 ? 11.527  36.151  -37.904 1.00 51.21  ? 141 TRP B CB  1 
ATOM   5072  C CG  . TRP B 1 141 ? 12.594  36.990  -37.257 1.00 54.56  ? 141 TRP B CG  1 
ATOM   5073  C CD1 . TRP B 1 141 ? 13.830  36.580  -36.849 1.00 56.75  ? 141 TRP B CD1 1 
ATOM   5074  C CD2 . TRP B 1 141 ? 12.534  38.409  -36.983 1.00 56.62  ? 141 TRP B CD2 1 
ATOM   5075  N NE1 . TRP B 1 141 ? 14.531  37.630  -36.320 1.00 56.41  ? 141 TRP B NE1 1 
ATOM   5076  C CE2 . TRP B 1 141 ? 13.771  38.766  -36.398 1.00 56.70  ? 141 TRP B CE2 1 
ATOM   5077  C CE3 . TRP B 1 141 ? 11.566  39.400  -37.178 1.00 52.99  ? 141 TRP B CE3 1 
ATOM   5078  C CZ2 . TRP B 1 141 ? 14.067  40.071  -36.012 1.00 56.90  ? 141 TRP B CZ2 1 
ATOM   5079  C CZ3 . TRP B 1 141 ? 11.866  40.688  -36.798 1.00 56.74  ? 141 TRP B CZ3 1 
ATOM   5080  C CH2 . TRP B 1 141 ? 13.095  41.019  -36.227 1.00 53.39  ? 141 TRP B CH2 1 
ATOM   5081  N N   . GLN B 1 142 ? 12.725  35.012  -40.622 1.00 63.12  ? 142 GLN B N   1 
ATOM   5082  C CA  . GLN B 1 142 ? 13.879  34.644  -41.434 1.00 61.07  ? 142 GLN B CA  1 
ATOM   5083  C C   . GLN B 1 142 ? 13.762  35.264  -42.832 1.00 48.55  ? 142 GLN B C   1 
ATOM   5084  O O   . GLN B 1 142 ? 14.762  35.646  -43.410 1.00 44.10  ? 142 GLN B O   1 
ATOM   5085  C CB  . GLN B 1 142 ? 14.075  33.122  -41.469 1.00 64.93  ? 142 GLN B CB  1 
ATOM   5086  C CG  . GLN B 1 142 ? 15.355  32.655  -42.165 1.00 72.89  ? 142 GLN B CG  1 
ATOM   5087  C CD  . GLN B 1 142 ? 15.272  32.647  -43.683 1.00 80.19  ? 142 GLN B CD  1 
ATOM   5088  O OE1 . GLN B 1 142 ? 14.188  32.704  -44.290 1.00 70.68  ? 142 GLN B OE1 1 
ATOM   5089  N NE2 . GLN B 1 142 ? 16.433  32.575  -44.324 1.00 75.95  ? 142 GLN B NE2 1 
ATOM   5090  N N   . ARG B 1 143 ? 12.552  35.378  -43.386 1.00 47.99  ? 143 ARG B N   1 
ATOM   5091  C CA  . ARG B 1 143 ? 12.389  35.942  -44.718 1.00 52.95  ? 143 ARG B CA  1 
ATOM   5092  C C   . ARG B 1 143 ? 12.624  37.454  -44.678 1.00 57.14  ? 143 ARG B C   1 
ATOM   5093  O O   . ARG B 1 143 ? 13.328  38.006  -45.528 1.00 54.97  ? 143 ARG B O   1 
ATOM   5094  C CB  . ARG B 1 143 ? 10.999  35.632  -45.294 1.00 60.19  ? 143 ARG B CB  1 
ATOM   5095  C CG  . ARG B 1 143 ? 10.816  36.036  -46.753 1.00 55.51  ? 143 ARG B CG  1 
ATOM   5096  C CD  . ARG B 1 143 ? 9.455   35.646  -47.324 1.00 55.13  ? 143 ARG B CD  1 
ATOM   5097  N NE  . ARG B 1 143 ? 8.307   36.153  -46.559 1.00 62.94  ? 143 ARG B NE  1 
ATOM   5098  C CZ  . ARG B 1 143 ? 7.917   37.430  -46.482 1.00 61.58  ? 143 ARG B CZ  1 
ATOM   5099  N NH1 . ARG B 1 143 ? 8.591   38.400  -47.083 1.00 55.14  ? 143 ARG B NH1 1 
ATOM   5100  N NH2 . ARG B 1 143 ? 6.845   37.735  -45.786 1.00 59.34  ? 143 ARG B NH2 1 
ATOM   5101  N N   . VAL B 1 144 ? 12.021  38.136  -43.700 1.00 51.54  ? 144 VAL B N   1 
ATOM   5102  C CA  . VAL B 1 144 ? 12.009  39.587  -43.746 1.00 55.25  ? 144 VAL B CA  1 
ATOM   5103  C C   . VAL B 1 144 ? 13.405  40.114  -43.414 1.00 52.76  ? 144 VAL B C   1 
ATOM   5104  O O   . VAL B 1 144 ? 13.789  41.147  -43.964 1.00 46.64  ? 144 VAL B O   1 
ATOM   5105  C CB  . VAL B 1 144 ? 10.897  40.253  -42.908 1.00 58.99  ? 144 VAL B CB  1 
ATOM   5106  C CG1 . VAL B 1 144 ? 9.502   39.801  -43.367 1.00 57.02  ? 144 VAL B CG1 1 
ATOM   5107  C CG2 . VAL B 1 144 ? 11.091  40.052  -41.410 1.00 58.04  ? 144 VAL B CG2 1 
ATOM   5108  N N   . THR B 1 145 ? 14.183  39.368  -42.607 1.00 53.22  ? 145 THR B N   1 
ATOM   5109  C CA  . THR B 1 145 ? 15.506  39.818  -42.173 1.00 54.09  ? 145 THR B CA  1 
ATOM   5110  C C   . THR B 1 145 ? 16.536  39.510  -43.257 1.00 57.41  ? 145 THR B C   1 
ATOM   5111  O O   . THR B 1 145 ? 17.510  40.232  -43.402 1.00 64.01  ? 145 THR B O   1 
ATOM   5112  C CB  . THR B 1 145 ? 15.933  39.188  -40.838 1.00 54.82  ? 145 THR B CB  1 
ATOM   5113  O OG1 . THR B 1 145 ? 15.866  37.774  -40.991 1.00 50.53  ? 145 THR B OG1 1 
ATOM   5114  C CG2 . THR B 1 145 ? 15.062  39.593  -39.658 1.00 54.85  ? 145 THR B CG2 1 
ATOM   5115  N N   . THR B 1 146 ? 16.319  38.423  -44.000 1.00 61.24  ? 146 THR B N   1 
ATOM   5116  C CA  . THR B 1 146 ? 17.238  37.984  -45.039 1.00 58.19  ? 146 THR B CA  1 
ATOM   5117  C C   . THR B 1 146 ? 17.087  38.893  -46.251 1.00 50.12  ? 146 THR B C   1 
ATOM   5118  O O   . THR B 1 146 ? 18.091  39.290  -46.803 1.00 53.14  ? 146 THR B O   1 
ATOM   5119  C CB  . THR B 1 146 ? 16.997  36.509  -45.413 1.00 55.48  ? 146 THR B CB  1 
ATOM   5120  O OG1 . THR B 1 146 ? 17.536  35.735  -44.347 1.00 49.22  ? 146 THR B OG1 1 
ATOM   5121  C CG2 . THR B 1 146 ? 17.691  36.072  -46.695 1.00 51.30  ? 146 THR B CG2 1 
ATOM   5122  N N   . ASP B 1 147 ? 15.843  39.150  -46.679 1.00 52.75  ? 147 ASP B N   1 
ATOM   5123  C CA  . ASP B 1 147 ? 15.529  39.923  -47.876 1.00 54.78  ? 147 ASP B CA  1 
ATOM   5124  C C   . ASP B 1 147 ? 15.457  41.427  -47.578 1.00 56.05  ? 147 ASP B C   1 
ATOM   5125  O O   . ASP B 1 147 ? 15.282  42.224  -48.503 1.00 56.32  ? 147 ASP B O   1 
ATOM   5126  C CB  . ASP B 1 147 ? 14.190  39.493  -48.470 1.00 54.76  ? 147 ASP B CB  1 
ATOM   5127  C CG  . ASP B 1 147 ? 14.103  38.082  -49.044 1.00 55.23  ? 147 ASP B CG  1 
ATOM   5128  O OD1 . ASP B 1 147 ? 15.159  37.427  -49.129 1.00 57.46  ? 147 ASP B OD1 1 
ATOM   5129  O OD2 . ASP B 1 147 ? 12.970  37.641  -49.381 1.00 55.09  ? 147 ASP B OD2 1 
ATOM   5130  N N   . ASP B 1 148 ? 15.518  41.801  -46.285 1.00 57.45  ? 148 ASP B N   1 
ATOM   5131  C CA  . ASP B 1 148 ? 15.459  43.191  -45.835 1.00 56.55  ? 148 ASP B CA  1 
ATOM   5132  C C   . ASP B 1 148 ? 14.171  43.893  -46.287 1.00 51.18  ? 148 ASP B C   1 
ATOM   5133  O O   . ASP B 1 148 ? 14.213  44.994  -46.832 1.00 49.70  ? 148 ASP B O   1 
ATOM   5134  C CB  . ASP B 1 148 ? 16.713  43.935  -46.262 1.00 55.78  ? 148 ASP B CB  1 
ATOM   5135  C CG  . ASP B 1 148 ? 17.056  45.185  -45.469 1.00 56.79  ? 148 ASP B CG  1 
ATOM   5136  O OD1 . ASP B 1 148 ? 16.390  45.442  -44.440 1.00 55.51  ? 148 ASP B OD1 1 
ATOM   5137  O OD2 . ASP B 1 148 ? 17.982  45.895  -45.906 1.00 60.45  ? 148 ASP B OD2 1 
ATOM   5138  N N   . VAL B 1 149 ? 13.015  43.257  -46.049 1.00 48.44  ? 149 VAL B N   1 
ATOM   5139  C CA  . VAL B 1 149 ? 11.729  43.837  -46.408 1.00 52.50  ? 149 VAL B CA  1 
ATOM   5140  C C   . VAL B 1 149 ? 11.410  45.006  -45.461 1.00 54.90  ? 149 VAL B C   1 
ATOM   5141  O O   . VAL B 1 149 ? 11.857  45.051  -44.312 1.00 53.38  ? 149 VAL B O   1 
ATOM   5142  C CB  . VAL B 1 149 ? 10.614  42.766  -46.380 1.00 55.82  ? 149 VAL B CB  1 
ATOM   5143  C CG1 . VAL B 1 149 ? 9.237   43.358  -46.652 1.00 57.36  ? 149 VAL B CG1 1 
ATOM   5144  C CG2 . VAL B 1 149 ? 10.865  41.601  -47.340 1.00 53.88  ? 149 VAL B CG2 1 
ATOM   5145  N N   . ALA B 1 150 ? 10.627  45.963  -45.969 1.00 53.05  ? 150 ALA B N   1 
ATOM   5146  C CA  . ALA B 1 150 ? 10.152  47.092  -45.194 1.00 56.81  ? 150 ALA B CA  1 
ATOM   5147  C C   . ALA B 1 150 ? 8.708   46.810  -44.775 1.00 51.45  ? 150 ALA B C   1 
ATOM   5148  O O   . ALA B 1 150 ? 7.865   46.441  -45.595 1.00 45.09  ? 150 ALA B O   1 
ATOM   5149  C CB  . ALA B 1 150 ? 10.291  48.379  -46.000 1.00 55.20  ? 150 ALA B CB  1 
ATOM   5150  N N   . LEU B 1 151 ? 8.433   46.980  -43.480 1.00 48.13  ? 151 LEU B N   1 
ATOM   5151  C CA  . LEU B 1 151 ? 7.136   46.618  -42.932 1.00 51.47  ? 151 LEU B CA  1 
ATOM   5152  C C   . LEU B 1 151 ? 6.578   47.784  -42.117 1.00 49.31  ? 151 LEU B C   1 
ATOM   5153  O O   . LEU B 1 151 ? 7.341   48.534  -41.510 1.00 46.75  ? 151 LEU B O   1 
ATOM   5154  C CB  . LEU B 1 151 ? 7.274   45.346  -42.095 1.00 56.32  ? 151 LEU B CB  1 
ATOM   5155  C CG  . LEU B 1 151 ? 7.734   44.095  -42.858 1.00 59.26  ? 151 LEU B CG  1 
ATOM   5156  C CD1 . LEU B 1 151 ? 9.122   43.665  -42.454 1.00 58.82  ? 151 LEU B CD1 1 
ATOM   5157  C CD2 . LEU B 1 151 ? 6.739   42.961  -42.696 1.00 65.20  ? 151 LEU B CD2 1 
ATOM   5158  N N   . SER B 1 152 ? 5.246   47.934  -42.128 1.00 43.36  ? 152 SER B N   1 
ATOM   5159  C CA  . SER B 1 152 ? 4.601   48.916  -41.279 1.00 52.65  ? 152 SER B CA  1 
ATOM   5160  C C   . SER B 1 152 ? 3.388   48.294  -40.610 1.00 48.70  ? 152 SER B C   1 
ATOM   5161  O O   . SER B 1 152 ? 2.566   47.702  -41.284 1.00 45.63  ? 152 SER B O   1 
ATOM   5162  C CB  . SER B 1 152 ? 4.205   50.145  -42.067 1.00 53.55  ? 152 SER B CB  1 
ATOM   5163  O OG  . SER B 1 152 ? 3.127   50.831  -41.457 1.00 46.37  ? 152 SER B OG  1 
ATOM   5164  N N   . PRO B 1 153 ? 3.185   48.518  -39.299 1.00 45.01  ? 153 PRO B N   1 
ATOM   5165  C CA  . PRO B 1 153 ? 2.015   47.975  -38.606 1.00 48.04  ? 153 PRO B CA  1 
ATOM   5166  C C   . PRO B 1 153 ? 0.729   48.725  -38.920 1.00 49.72  ? 153 PRO B C   1 
ATOM   5167  O O   . PRO B 1 153 ? 0.756   49.932  -39.084 1.00 51.97  ? 153 PRO B O   1 
ATOM   5168  C CB  . PRO B 1 153 ? 2.422   48.166  -37.139 1.00 49.64  ? 153 PRO B CB  1 
ATOM   5169  C CG  . PRO B 1 153 ? 3.214   49.466  -37.163 1.00 47.84  ? 153 PRO B CG  1 
ATOM   5170  C CD  . PRO B 1 153 ? 4.039   49.356  -38.444 1.00 43.90  ? 153 PRO B CD  1 
ATOM   5171  N N   . MET B 1 154 ? -0.398  48.015  -38.979 1.00 53.04  ? 154 MET B N   1 
ATOM   5172  C CA  . MET B 1 154 ? -1.702  48.657  -38.901 1.00 50.39  ? 154 MET B CA  1 
ATOM   5173  C C   . MET B 1 154 ? -2.521  47.921  -37.847 1.00 51.42  ? 154 MET B C   1 
ATOM   5174  O O   . MET B 1 154 ? -2.995  46.822  -38.099 1.00 50.56  ? 154 MET B O   1 
ATOM   5175  C CB  . MET B 1 154 ? -2.441  48.622  -40.242 1.00 49.28  ? 154 MET B CB  1 
ATOM   5176  C CG  . MET B 1 154 ? -1.695  49.295  -41.365 1.00 52.68  ? 154 MET B CG  1 
ATOM   5177  S SD  . MET B 1 154 ? -2.738  49.644  -42.788 1.00 52.96  ? 154 MET B SD  1 
ATOM   5178  C CE  . MET B 1 154 ? -3.909  50.865  -42.179 1.00 59.52  ? 154 MET B CE  1 
ATOM   5179  N N   . PHE B 1 155 ? -2.637  48.505  -36.649 1.00 53.81  ? 155 PHE B N   1 
ATOM   5180  C CA  . PHE B 1 155 ? -3.262  47.816  -35.526 1.00 56.67  ? 155 PHE B CA  1 
ATOM   5181  C C   . PHE B 1 155 ? -4.562  48.508  -35.097 1.00 55.05  ? 155 PHE B C   1 
ATOM   5182  O O   . PHE B 1 155 ? -5.440  47.872  -34.509 1.00 73.74  ? 155 PHE B O   1 
ATOM   5183  C CB  . PHE B 1 155 ? -2.229  47.672  -34.404 1.00 52.87  ? 155 PHE B CB  1 
ATOM   5184  C CG  . PHE B 1 155 ? -1.300  46.465  -34.493 1.00 54.20  ? 155 PHE B CG  1 
ATOM   5185  C CD1 . PHE B 1 155 ? -0.503  46.237  -35.607 1.00 55.72  ? 155 PHE B CD1 1 
ATOM   5186  C CD2 . PHE B 1 155 ? -1.230  45.542  -33.446 1.00 56.98  ? 155 PHE B CD2 1 
ATOM   5187  C CE1 . PHE B 1 155 ? 0.347   45.127  -35.662 1.00 62.04  ? 155 PHE B CE1 1 
ATOM   5188  C CE2 . PHE B 1 155 ? -0.377  44.446  -33.502 1.00 60.34  ? 155 PHE B CE2 1 
ATOM   5189  C CZ  . PHE B 1 155 ? 0.412   44.237  -34.613 1.00 62.12  ? 155 PHE B CZ  1 
ATOM   5190  N N   . VAL B 1 156 ? -4.711  49.794  -35.420 1.00 54.27  ? 156 VAL B N   1 
ATOM   5191  C CA  . VAL B 1 156 ? -5.849  50.589  -34.982 1.00 53.59  ? 156 VAL B CA  1 
ATOM   5192  C C   . VAL B 1 156 ? -7.071  50.328  -35.881 1.00 55.66  ? 156 VAL B C   1 
ATOM   5193  O O   . VAL B 1 156 ? -6.961  50.247  -37.117 1.00 55.28  ? 156 VAL B O   1 
ATOM   5194  C CB  . VAL B 1 156 ? -5.430  52.080  -34.936 1.00 58.23  ? 156 VAL B CB  1 
ATOM   5195  C CG1 . VAL B 1 156 ? -6.610  53.013  -34.679 1.00 59.20  ? 156 VAL B CG1 1 
ATOM   5196  C CG2 . VAL B 1 156 ? -4.335  52.346  -33.897 1.00 54.76  ? 156 VAL B CG2 1 
ATOM   5197  N N   . ASP B 1 157 ? -8.245  50.260  -35.223 1.00 54.19  ? 157 ASP B N   1 
ATOM   5198  C CA  . ASP B 1 157 ? -9.525  49.951  -35.844 1.00 58.60  ? 157 ASP B CA  1 
ATOM   5199  C C   . ASP B 1 157 ? -10.481 51.139  -35.815 1.00 58.34  ? 157 ASP B C   1 
ATOM   5200  O O   . ASP B 1 157 ? -10.384 52.013  -34.964 1.00 64.69  ? 157 ASP B O   1 
ATOM   5201  C CB  . ASP B 1 157 ? -10.187 48.757  -35.170 1.00 59.16  ? 157 ASP B CB  1 
ATOM   5202  C CG  . ASP B 1 157 ? -9.518  47.435  -35.510 1.00 65.83  ? 157 ASP B CG  1 
ATOM   5203  O OD1 . ASP B 1 157 ? -9.530  47.067  -36.711 1.00 66.87  ? 157 ASP B OD1 1 
ATOM   5204  O OD2 . ASP B 1 157 ? -8.918  46.831  -34.600 1.00 65.02  ? 157 ASP B OD2 1 
ATOM   5205  N N   . VAL B 1 158 ? -11.465 51.042  -36.705 1.00 65.98  ? 158 VAL B N   1 
ATOM   5206  C CA  . VAL B 1 158 ? -12.535 52.066  -36.776 1.00 76.65  ? 158 VAL B CA  1 
ATOM   5207  C C   . VAL B 1 158 ? -13.470 51.872  -35.578 1.00 78.18  ? 158 VAL B C   1 
ATOM   5208  O O   . VAL B 1 158 ? -13.649 50.725  -35.133 1.00 83.10  ? 158 VAL B O   1 
ATOM   5209  C CB  . VAL B 1 158 ? -13.276 51.886  -38.115 1.00 66.68  ? 158 VAL B CB  1 
ATOM   5210  C CG1 . VAL B 1 158 ? -12.393 52.250  -39.301 1.00 67.94  ? 158 VAL B CG1 1 
ATOM   5211  C CG2 . VAL B 1 158 ? -13.842 50.483  -38.285 1.00 66.79  ? 158 VAL B CG2 1 
ATOM   5212  N N   . GLN B 1 159 ? -14.031 52.966  -35.074 1.00 96.85  ? 159 GLN B N   1 
ATOM   5213  C CA  . GLN B 1 159 ? -14.984 52.875  -33.943 1.00 110.04 ? 159 GLN B CA  1 
ATOM   5214  C C   . GLN B 1 159 ? -16.325 52.362  -34.476 1.00 110.27 ? 159 GLN B C   1 
ATOM   5215  O O   . GLN B 1 159 ? -16.630 52.620  -35.658 1.00 105.64 ? 159 GLN B O   1 
ATOM   5216  C CB  . GLN B 1 159 ? -15.147 54.244  -33.283 1.00 117.45 ? 159 GLN B CB  1 
ATOM   5217  C CG  . GLN B 1 159 ? -14.157 55.299  -33.767 1.00 123.61 ? 159 GLN B CG  1 
ATOM   5218  C CD  . GLN B 1 159 ? -14.037 56.490  -32.840 1.00 124.27 ? 159 GLN B CD  1 
ATOM   5219  O OE1 . GLN B 1 159 ? -12.940 56.999  -32.586 1.00 121.86 ? 159 GLN B OE1 1 
ATOM   5220  N NE2 . GLN B 1 159 ? -15.169 56.945  -32.322 1.00 122.10 ? 159 GLN B NE2 1 
ATOM   5221  N N   . PHE B 1 160 ? -17.088 51.663  -33.640 1.00 107.50 ? 160 PHE B N   1 
ATOM   5222  C CA  . PHE B 1 160 ? -18.441 51.222  -34.063 1.00 112.22 ? 160 PHE B CA  1 
ATOM   5223  C C   . PHE B 1 160 ? -19.298 51.024  -32.816 1.00 108.46 ? 160 PHE B C   1 
ATOM   5224  O O   . PHE B 1 160 ? -20.352 51.694  -32.746 1.00 110.39 ? 160 PHE B O   1 
ATOM   5225  C CB  . PHE B 1 160 ? -18.336 49.967  -34.933 1.00 121.28 ? 160 PHE B CB  1 
ATOM   5226  C CG  . PHE B 1 160 ? -19.484 49.837  -35.921 1.00 127.64 ? 160 PHE B CG  1 
ATOM   5227  C CD1 . PHE B 1 160 ? -19.575 50.684  -37.017 1.00 126.95 ? 160 PHE B CD1 1 
ATOM   5228  C CD2 . PHE B 1 160 ? -20.479 48.887  -35.736 1.00 132.57 ? 160 PHE B CD2 1 
ATOM   5229  C CE1 . PHE B 1 160 ? -20.631 50.576  -37.906 1.00 133.74 ? 160 PHE B CE1 1 
ATOM   5230  C CE2 . PHE B 1 160 ? -21.530 48.782  -36.631 1.00 128.02 ? 160 PHE B CE2 1 
ATOM   5231  C CZ  . PHE B 1 160 ? -21.602 49.624  -37.714 1.00 134.30 ? 160 PHE B CZ  1 
ATOM   5232  N N   . GLU B 1 170 ? -22.356 42.703  -40.413 1.00 86.00  ? 170 GLU B N   1 
ATOM   5233  C CA  . GLU B 1 170 ? -20.911 42.919  -40.705 1.00 90.13  ? 170 GLU B CA  1 
ATOM   5234  C C   . GLU B 1 170 ? -20.539 44.381  -40.442 1.00 87.31  ? 170 GLU B C   1 
ATOM   5235  O O   . GLU B 1 170 ? -21.042 45.283  -41.115 1.00 80.35  ? 170 GLU B O   1 
ATOM   5236  C CB  . GLU B 1 170 ? -20.614 42.552  -42.162 1.00 89.86  ? 170 GLU B CB  1 
ATOM   5237  C CG  . GLU B 1 170 ? -19.130 42.566  -42.523 1.00 88.29  ? 170 GLU B CG  1 
ATOM   5238  C CD  . GLU B 1 170 ? -18.901 42.410  -44.012 1.00 81.30  ? 170 GLU B CD  1 
ATOM   5239  O OE1 . GLU B 1 170 ? -17.731 42.383  -44.433 1.00 80.22  ? 170 GLU B OE1 1 
ATOM   5240  O OE2 . GLU B 1 170 ? -19.903 42.324  -44.753 1.00 79.31  ? 170 GLU B OE2 1 
ATOM   5241  N N   . THR B 1 171 ? -19.640 44.597  -39.471 1.00 79.27  ? 171 THR B N   1 
ATOM   5242  C CA  . THR B 1 171 ? -19.113 45.921  -39.180 1.00 79.80  ? 171 THR B CA  1 
ATOM   5243  C C   . THR B 1 171 ? -18.092 46.268  -40.267 1.00 74.77  ? 171 THR B C   1 
ATOM   5244  O O   . THR B 1 171 ? -17.612 45.376  -40.972 1.00 67.36  ? 171 THR B O   1 
ATOM   5245  C CB  . THR B 1 171 ? -18.501 46.012  -37.771 1.00 88.21  ? 171 THR B CB  1 
ATOM   5246  O OG1 . THR B 1 171 ? -17.168 45.508  -37.781 1.00 86.84  ? 171 THR B OG1 1 
ATOM   5247  C CG2 . THR B 1 171 ? -19.309 45.295  -36.699 1.00 87.38  ? 171 THR B CG2 1 
ATOM   5248  N N   . PRO B 1 172 ? -17.739 47.568  -40.435 1.00 67.54  ? 172 PRO B N   1 
ATOM   5249  C CA  . PRO B 1 172 ? -16.744 47.993  -41.423 1.00 65.38  ? 172 PRO B CA  1 
ATOM   5250  C C   . PRO B 1 172 ? -15.312 47.637  -41.039 1.00 57.26  ? 172 PRO B C   1 
ATOM   5251  O O   . PRO B 1 172 ? -14.398 47.789  -41.842 1.00 58.91  ? 172 PRO B O   1 
ATOM   5252  C CB  . PRO B 1 172 ? -16.940 49.539  -41.503 1.00 66.56  ? 172 PRO B CB  1 
ATOM   5253  C CG  . PRO B 1 172 ? -18.250 49.800  -40.782 1.00 67.17  ? 172 PRO B CG  1 
ATOM   5254  C CD  . PRO B 1 172 ? -18.308 48.719  -39.715 1.00 67.27  ? 172 PRO B CD  1 
ATOM   5255  N N   . MET B 1 173 ? -15.118 47.214  -39.790 1.00 57.21  ? 173 MET B N   1 
ATOM   5256  C CA  . MET B 1 173 ? -13.811 46.798  -39.305 1.00 63.14  ? 173 MET B CA  1 
ATOM   5257  C C   . MET B 1 173 ? -13.330 45.579  -40.097 1.00 62.11  ? 173 MET B C   1 
ATOM   5258  O O   . MET B 1 173 ? -14.146 44.784  -40.564 1.00 57.25  ? 173 MET B O   1 
ATOM   5259  C CB  . MET B 1 173 ? -13.940 46.466  -37.817 1.00 64.00  ? 173 MET B CB  1 
ATOM   5260  C CG  . MET B 1 173 ? -12.691 45.953  -37.153 1.00 71.30  ? 173 MET B CG  1 
ATOM   5261  S SD  . MET B 1 173 ? -13.162 45.424  -35.496 1.00 79.26  ? 173 MET B SD  1 
ATOM   5262  C CE  . MET B 1 173 ? -11.642 44.871  -34.707 1.00 86.73  ? 173 MET B CE  1 
ATOM   5263  N N   . LEU B 1 174 ? -12.003 45.424  -40.229 1.00 57.44  ? 174 LEU B N   1 
ATOM   5264  C CA  . LEU B 1 174 ? -11.428 44.264  -40.899 1.00 52.84  ? 174 LEU B CA  1 
ATOM   5265  C C   . LEU B 1 174 ? -11.852 42.994  -40.161 1.00 56.46  ? 174 LEU B C   1 
ATOM   5266  O O   . LEU B 1 174 ? -11.808 42.950  -38.932 1.00 57.44  ? 174 LEU B O   1 
ATOM   5267  C CB  . LEU B 1 174 ? -9.905  44.338  -40.965 1.00 48.54  ? 174 LEU B CB  1 
ATOM   5268  C CG  . LEU B 1 174 ? -9.247  43.241  -41.806 1.00 53.64  ? 174 LEU B CG  1 
ATOM   5269  C CD1 . LEU B 1 174 ? -9.680  43.409  -43.269 1.00 54.63  ? 174 LEU B CD1 1 
ATOM   5270  C CD2 . LEU B 1 174 ? -7.734  43.218  -41.684 1.00 54.06  ? 174 LEU B CD2 1 
ATOM   5271  N N   . SER B 1 175 ? -12.273 41.972  -40.922 1.00 53.38  ? 175 SER B N   1 
ATOM   5272  C CA  . SER B 1 175 ? -12.724 40.708  -40.348 1.00 55.91  ? 175 SER B CA  1 
ATOM   5273  C C   . SER B 1 175 ? -12.695 39.596  -41.397 1.00 57.47  ? 175 SER B C   1 
ATOM   5274  O O   . SER B 1 175 ? -12.829 39.853  -42.594 1.00 51.48  ? 175 SER B O   1 
ATOM   5275  C CB  . SER B 1 175 ? -14.099 40.820  -39.717 1.00 54.90  ? 175 SER B CB  1 
ATOM   5276  O OG  . SER B 1 175 ? -15.123 40.933  -40.694 1.00 52.32  ? 175 SER B OG  1 
ATOM   5277  N N   . ILE B 1 176 ? -12.527 38.356  -40.907 1.00 61.90  ? 176 ILE B N   1 
ATOM   5278  C CA  . ILE B 1 176 ? -12.501 37.150  -41.724 1.00 57.13  ? 176 ILE B CA  1 
ATOM   5279  C C   . ILE B 1 176 ? -13.903 36.853  -42.257 1.00 51.73  ? 176 ILE B C   1 
ATOM   5280  O O   . ILE B 1 176 ? -14.834 36.729  -41.465 1.00 53.68  ? 176 ILE B O   1 
ATOM   5281  C CB  . ILE B 1 176 ? -11.999 35.973  -40.872 1.00 59.94  ? 176 ILE B CB  1 
ATOM   5282  C CG1 . ILE B 1 176 ? -10.645 36.270  -40.236 1.00 62.49  ? 176 ILE B CG1 1 
ATOM   5283  C CG2 . ILE B 1 176 ? -11.977 34.692  -41.706 1.00 60.13  ? 176 ILE B CG2 1 
ATOM   5284  C CD1 . ILE B 1 176 ? -10.283 35.344  -39.089 1.00 63.29  ? 176 ILE B CD1 1 
ATOM   5285  N N   . VAL B 1 177 ? -14.044 36.678  -43.583 1.00 55.90  ? 177 VAL B N   1 
ATOM   5286  C CA  . VAL B 1 177 ? -15.331 36.326  -44.191 1.00 60.64  ? 177 VAL B CA  1 
ATOM   5287  C C   . VAL B 1 177 ? -15.277 34.942  -44.857 1.00 59.91  ? 177 VAL B C   1 
ATOM   5288  O O   . VAL B 1 177 ? -16.299 34.436  -45.314 1.00 57.59  ? 177 VAL B O   1 
ATOM   5289  C CB  . VAL B 1 177 ? -15.827 37.388  -45.198 1.00 64.88  ? 177 VAL B CB  1 
ATOM   5290  C CG1 . VAL B 1 177 ? -16.111 38.725  -44.522 1.00 65.87  ? 177 VAL B CG1 1 
ATOM   5291  C CG2 . VAL B 1 177 ? -14.869 37.573  -46.373 1.00 62.72  ? 177 VAL B CG2 1 
ATOM   5292  N N   . GLU B 1 178 ? -14.091 34.333  -44.919 1.00 58.73  ? 178 GLU B N   1 
ATOM   5293  C CA  . GLU B 1 178 ? -13.935 32.966  -45.383 1.00 64.17  ? 178 GLU B CA  1 
ATOM   5294  C C   . GLU B 1 178 ? -12.633 32.398  -44.813 1.00 69.20  ? 178 GLU B C   1 
ATOM   5295  O O   . GLU B 1 178 ? -11.663 33.138  -44.617 1.00 60.36  ? 178 GLU B O   1 
ATOM   5296  C CB  . GLU B 1 178 ? -13.916 32.930  -46.913 1.00 69.63  ? 178 GLU B CB  1 
ATOM   5297  C CG  . GLU B 1 178 ? -13.897 31.527  -47.521 1.00 66.33  ? 178 GLU B CG  1 
ATOM   5298  C CD  . GLU B 1 178 ? -13.525 31.504  -48.994 1.00 66.55  ? 178 GLU B CD  1 
ATOM   5299  O OE1 . GLU B 1 178 ? -14.208 32.139  -49.832 1.00 70.16  ? 178 GLU B OE1 1 
ATOM   5300  O OE2 . GLU B 1 178 ? -12.515 30.848  -49.294 1.00 66.11  ? 178 GLU B OE2 1 
ATOM   5301  N N   . GLN B 1 179 ? -12.660 31.089  -44.510 1.00 71.38  ? 179 GLN B N   1 
ATOM   5302  C CA  . GLN B 1 179 ? -11.471 30.291  -44.253 1.00 65.40  ? 179 GLN B CA  1 
ATOM   5303  C C   . GLN B 1 179 ? -11.487 29.125  -45.242 1.00 71.89  ? 179 GLN B C   1 
ATOM   5304  O O   . GLN B 1 179 ? -12.550 28.619  -45.595 1.00 68.59  ? 179 GLN B O   1 
ATOM   5305  C CB  . GLN B 1 179 ? -11.425 29.851  -42.787 1.00 67.61  ? 179 GLN B CB  1 
ATOM   5306  C CG  . GLN B 1 179 ? -11.540 31.013  -41.798 1.00 69.74  ? 179 GLN B CG  1 
ATOM   5307  C CD  . GLN B 1 179 ? -11.287 30.640  -40.349 1.00 66.59  ? 179 GLN B CD  1 
ATOM   5308  O OE1 . GLN B 1 179 ? -10.404 29.832  -40.045 1.00 66.01  ? 179 GLN B OE1 1 
ATOM   5309  N NE2 . GLN B 1 179 ? -12.052 31.225  -39.435 1.00 62.25  ? 179 GLN B NE2 1 
ATOM   5310  N N   . ASN B 1 180 ? -10.307 28.750  -45.745 1.00 71.22  ? 180 ASN B N   1 
ATOM   5311  C CA  . ASN B 1 180 ? -10.184 27.640  -46.671 1.00 65.61  ? 180 ASN B CA  1 
ATOM   5312  C C   . ASN B 1 180 ? -8.792  27.032  -46.485 1.00 76.46  ? 180 ASN B C   1 
ATOM   5313  O O   . ASN B 1 180 ? -8.021  27.501  -45.648 1.00 76.82  ? 180 ASN B O   1 
ATOM   5314  C CB  . ASN B 1 180 ? -10.530 28.071  -48.092 1.00 56.95  ? 180 ASN B CB  1 
ATOM   5315  C CG  . ASN B 1 180 ? -9.520  29.039  -48.662 1.00 57.52  ? 180 ASN B CG  1 
ATOM   5316  O OD1 . ASN B 1 180 ? -8.300  28.834  -48.559 1.00 51.61  ? 180 ASN B OD1 1 
ATOM   5317  N ND2 . ASN B 1 180 ? -10.009 30.108  -49.271 1.00 57.89  ? 180 ASN B ND2 1 
ATOM   5318  N N   . ASP B 1 181 ? -8.485  25.980  -47.260 1.00 74.00  ? 181 ASP B N   1 
ATOM   5319  C CA  . ASP B 1 181 ? -7.289  25.177  -47.053 1.00 69.54  ? 181 ASP B CA  1 
ATOM   5320  C C   . ASP B 1 181 ? -6.054  25.992  -47.409 1.00 64.69  ? 181 ASP B C   1 
ATOM   5321  O O   . ASP B 1 181 ? -4.964  25.708  -46.901 1.00 55.31  ? 181 ASP B O   1 
ATOM   5322  C CB  . ASP B 1 181 ? -7.327  23.875  -47.850 1.00 74.97  ? 181 ASP B CB  1 
ATOM   5323  C CG  . ASP B 1 181 ? -8.452  22.892  -47.525 1.00 75.24  ? 181 ASP B CG  1 
ATOM   5324  O OD1 . ASP B 1 181 ? -9.181  23.103  -46.516 1.00 61.22  ? 181 ASP B OD1 1 
ATOM   5325  O OD2 . ASP B 1 181 ? -8.605  21.917  -48.300 1.00 75.58  ? 181 ASP B OD2 1 
ATOM   5326  N N   . GLN B 1 182 ? -6.231  26.992  -48.290 1.00 63.44  ? 182 GLN B N   1 
ATOM   5327  C CA  . GLN B 1 182 ? -5.101  27.776  -48.758 1.00 67.51  ? 182 GLN B CA  1 
ATOM   5328  C C   . GLN B 1 182 ? -4.788  28.918  -47.775 1.00 60.98  ? 182 GLN B C   1 
ATOM   5329  O O   . GLN B 1 182 ? -3.620  29.282  -47.628 1.00 55.12  ? 182 GLN B O   1 
ATOM   5330  C CB  . GLN B 1 182 ? -5.292  28.212  -50.215 1.00 78.75  ? 182 GLN B CB  1 
ATOM   5331  C CG  . GLN B 1 182 ? -4.042  27.969  -51.069 1.00 94.41  ? 182 GLN B CG  1 
ATOM   5332  C CD  . GLN B 1 182 ? -3.822  28.951  -52.209 1.00 98.69  ? 182 GLN B CD  1 
ATOM   5333  O OE1 . GLN B 1 182 ? -2.747  29.563  -52.335 1.00 76.41  ? 182 GLN B OE1 1 
ATOM   5334  N NE2 . GLN B 1 182 ? -4.825  29.093  -53.069 1.00 99.84  ? 182 GLN B NE2 1 
ATOM   5335  N N   . GLY B 1 183 ? -5.802  29.467  -47.083 1.00 58.91  ? 183 GLY B N   1 
ATOM   5336  C CA  . GLY B 1 183 ? -5.598  30.611  -46.194 1.00 65.68  ? 183 GLY B CA  1 
ATOM   5337  C C   . GLY B 1 183 ? -6.915  31.315  -45.863 1.00 67.25  ? 183 GLY B C   1 
ATOM   5338  O O   . GLY B 1 183 ? -7.961  30.667  -45.868 1.00 64.65  ? 183 GLY B O   1 
ATOM   5339  N N   . ILE B 1 184 ? -6.872  32.641  -45.597 1.00 61.72  ? 184 ILE B N   1 
ATOM   5340  C CA  . ILE B 1 184 ? -8.075  33.363  -45.180 1.00 55.27  ? 184 ILE B CA  1 
ATOM   5341  C C   . ILE B 1 184 ? -8.380  34.478  -46.174 1.00 55.57  ? 184 ILE B C   1 
ATOM   5342  O O   . ILE B 1 184 ? -7.487  34.954  -46.871 1.00 60.21  ? 184 ILE B O   1 
ATOM   5343  C CB  . ILE B 1 184 ? -7.995  33.907  -43.733 1.00 53.87  ? 184 ILE B CB  1 
ATOM   5344  C CG1 . ILE B 1 184 ? -6.948  35.028  -43.553 1.00 54.74  ? 184 ILE B CG1 1 
ATOM   5345  C CG2 . ILE B 1 184 ? -7.777  32.785  -42.714 1.00 49.66  ? 184 ILE B CG2 1 
ATOM   5346  C CD1 . ILE B 1 184 ? -6.841  35.558  -42.125 1.00 49.99  ? 184 ILE B CD1 1 
ATOM   5347  N N   . VAL B 1 185 ? -9.661  34.871  -46.206 1.00 53.39  ? 185 VAL B N   1 
ATOM   5348  C CA  . VAL B 1 185 ? -10.112 36.077  -46.877 1.00 56.64  ? 185 VAL B CA  1 
ATOM   5349  C C   . VAL B 1 185 ? -10.647 37.065  -45.834 1.00 58.79  ? 185 VAL B C   1 
ATOM   5350  O O   . VAL B 1 185 ? -11.384 36.678  -44.923 1.00 64.21  ? 185 VAL B O   1 
ATOM   5351  C CB  . VAL B 1 185 ? -11.173 35.731  -47.943 1.00 58.45  ? 185 VAL B CB  1 
ATOM   5352  C CG1 . VAL B 1 185 ? -11.655 36.968  -48.695 1.00 58.05  ? 185 VAL B CG1 1 
ATOM   5353  C CG2 . VAL B 1 185 ? -10.664 34.682  -48.929 1.00 56.48  ? 185 VAL B CG2 1 
ATOM   5354  N N   . VAL B 1 186 ? -10.285 38.351  -45.989 1.00 59.88  ? 186 VAL B N   1 
ATOM   5355  C CA  . VAL B 1 186 ? -10.631 39.404  -45.034 1.00 61.72  ? 186 VAL B CA  1 
ATOM   5356  C C   . VAL B 1 186 ? -11.277 40.566  -45.793 1.00 65.48  ? 186 VAL B C   1 
ATOM   5357  O O   . VAL B 1 186 ? -10.899 40.863  -46.928 1.00 61.60  ? 186 VAL B O   1 
ATOM   5358  C CB  . VAL B 1 186 ? -9.408  39.897  -44.228 1.00 60.84  ? 186 VAL B CB  1 
ATOM   5359  C CG1 . VAL B 1 186 ? -8.760  38.777  -43.417 1.00 59.69  ? 186 VAL B CG1 1 
ATOM   5360  C CG2 . VAL B 1 186 ? -8.348  40.568  -45.113 1.00 58.77  ? 186 VAL B CG2 1 
ATOM   5361  N N   . ARG B 1 187 ? -12.247 41.230  -45.150 1.00 65.98  ? 187 ARG B N   1 
ATOM   5362  C CA  . ARG B 1 187 ? -12.900 42.390  -45.736 1.00 65.29  ? 187 ARG B CA  1 
ATOM   5363  C C   . ARG B 1 187 ? -13.057 43.482  -44.678 1.00 58.99  ? 187 ARG B C   1 
ATOM   5364  O O   . ARG B 1 187 ? -13.341 43.164  -43.530 1.00 51.57  ? 187 ARG B O   1 
ATOM   5365  C CB  . ARG B 1 187 ? -14.246 41.976  -46.338 1.00 69.74  ? 187 ARG B CB  1 
ATOM   5366  C CG  . ARG B 1 187 ? -14.968 43.119  -47.040 1.00 74.55  ? 187 ARG B CG  1 
ATOM   5367  C CD  . ARG B 1 187 ? -16.142 42.674  -47.912 1.00 73.48  ? 187 ARG B CD  1 
ATOM   5368  N NE  . ARG B 1 187 ? -17.192 41.976  -47.160 1.00 71.79  ? 187 ARG B NE  1 
ATOM   5369  C CZ  . ARG B 1 187 ? -17.602 40.726  -47.393 1.00 69.22  ? 187 ARG B CZ  1 
ATOM   5370  N NH1 . ARG B 1 187 ? -17.158 40.044  -48.436 1.00 63.13  ? 187 ARG B NH1 1 
ATOM   5371  N NH2 . ARG B 1 187 ? -18.460 40.156  -46.572 1.00 65.57  ? 187 ARG B NH2 1 
ATOM   5372  N N   . GLY B 1 188 ? -12.853 44.755  -45.085 1.00 61.51  ? 188 GLY B N   1 
ATOM   5373  C CA  . GLY B 1 188 ? -13.067 45.938  -44.250 1.00 52.36  ? 188 GLY B CA  1 
ATOM   5374  C C   . GLY B 1 188 ? -11.818 46.815  -44.084 1.00 53.86  ? 188 GLY B C   1 
ATOM   5375  O O   . GLY B 1 188 ? -10.814 46.652  -44.781 1.00 55.68  ? 188 GLY B O   1 
ATOM   5376  N N   . TRP B 1 189 ? -11.881 47.718  -43.101 1.00 51.03  ? 189 TRP B N   1 
ATOM   5377  C CA  . TRP B 1 189 ? -10.894 48.768  -42.913 1.00 50.28  ? 189 TRP B CA  1 
ATOM   5378  C C   . TRP B 1 189 ? -9.900  48.448  -41.799 1.00 49.65  ? 189 TRP B C   1 
ATOM   5379  O O   . TRP B 1 189 ? -10.272 47.884  -40.772 1.00 46.38  ? 189 TRP B O   1 
ATOM   5380  C CB  . TRP B 1 189 ? -11.606 50.083  -42.571 1.00 53.49  ? 189 TRP B CB  1 
ATOM   5381  C CG  . TRP B 1 189 ? -12.417 50.667  -43.699 1.00 57.79  ? 189 TRP B CG  1 
ATOM   5382  C CD1 . TRP B 1 189 ? -13.750 50.489  -43.924 1.00 56.46  ? 189 TRP B CD1 1 
ATOM   5383  C CD2 . TRP B 1 189 ? -11.942 51.533  -44.754 1.00 50.57  ? 189 TRP B CD2 1 
ATOM   5384  N NE1 . TRP B 1 189 ? -14.139 51.190  -45.035 1.00 54.19  ? 189 TRP B NE1 1 
ATOM   5385  C CE2 . TRP B 1 189 ? -13.058 51.833  -45.570 1.00 54.82  ? 189 TRP B CE2 1 
ATOM   5386  C CE3 . TRP B 1 189 ? -10.694 52.075  -45.087 1.00 53.82  ? 189 TRP B CE3 1 
ATOM   5387  C CZ2 . TRP B 1 189 ? -12.962 52.644  -46.701 1.00 61.80  ? 189 TRP B CZ2 1 
ATOM   5388  C CZ3 . TRP B 1 189 ? -10.596 52.870  -46.208 1.00 58.82  ? 189 TRP B CZ3 1 
ATOM   5389  C CH2 . TRP B 1 189 ? -11.717 53.152  -47.002 1.00 63.51  ? 189 TRP B CH2 1 
ATOM   5390  N N   . LYS B 1 190 ? -8.645  48.885  -42.009 1.00 50.13  ? 190 LYS B N   1 
ATOM   5391  C CA  . LYS B 1 190 ? -7.737  49.263  -40.935 1.00 51.17  ? 190 LYS B CA  1 
ATOM   5392  C C   . LYS B 1 190 ? -7.615  50.794  -40.906 1.00 55.63  ? 190 LYS B C   1 
ATOM   5393  O O   . LYS B 1 190 ? -7.560  51.436  -41.960 1.00 51.33  ? 190 LYS B O   1 
ATOM   5394  C CB  . LYS B 1 190 ? -6.403  48.528  -41.096 1.00 52.49  ? 190 LYS B CB  1 
ATOM   5395  C CG  . LYS B 1 190 ? -6.509  47.003  -41.014 1.00 52.80  ? 190 LYS B CG  1 
ATOM   5396  C CD  . LYS B 1 190 ? -7.110  46.456  -39.718 1.00 53.78  ? 190 LYS B CD  1 
ATOM   5397  C CE  . LYS B 1 190 ? -6.236  46.619  -38.516 1.00 51.67  ? 190 LYS B CE  1 
ATOM   5398  N NZ  . LYS B 1 190 ? -7.025  46.367  -37.312 1.00 54.03  ? 190 LYS B NZ  1 
ATOM   5399  N N   . ALA B 1 191 ? -7.565  51.363  -39.684 1.00 60.10  ? 191 ALA B N   1 
ATOM   5400  C CA  . ALA B 1 191 ? -7.991  52.737  -39.437 1.00 61.06  ? 191 ALA B CA  1 
ATOM   5401  C C   . ALA B 1 191 ? -6.835  53.727  -39.506 1.00 61.92  ? 191 ALA B C   1 
ATOM   5402  O O   . ALA B 1 191 ? -7.054  54.886  -39.853 1.00 63.39  ? 191 ALA B O   1 
ATOM   5403  C CB  . ALA B 1 191 ? -8.694  52.858  -38.101 1.00 65.56  ? 191 ALA B CB  1 
ATOM   5404  N N   . MET B 1 192 ? -5.624  53.305  -39.131 1.00 65.17  ? 192 MET B N   1 
ATOM   5405  C CA  . MET B 1 192 ? -4.490  54.214  -39.187 1.00 63.22  ? 192 MET B CA  1 
ATOM   5406  C C   . MET B 1 192 ? -3.201  53.411  -39.274 1.00 56.52  ? 192 MET B C   1 
ATOM   5407  O O   . MET B 1 192 ? -3.062  52.357  -38.658 1.00 64.81  ? 192 MET B O   1 
ATOM   5408  C CB  . MET B 1 192 ? -4.415  55.177  -37.989 1.00 70.81  ? 192 MET B CB  1 
ATOM   5409  C CG  . MET B 1 192 ? -3.464  56.349  -38.237 1.00 82.15  ? 192 MET B CG  1 
ATOM   5410  S SD  . MET B 1 192 ? -3.581  57.675  -37.020 1.00 120.17 ? 192 MET B SD  1 
ATOM   5411  C CE  . MET B 1 192 ? -2.309  57.408  -35.771 1.00 112.33 ? 192 MET B CE  1 
ATOM   5412  N N   . GLY B 1 193 ? -2.298  53.929  -40.101 1.00 48.48  ? 193 GLY B N   1 
ATOM   5413  C CA  . GLY B 1 193 ? -0.980  53.373  -40.302 1.00 46.63  ? 193 GLY B CA  1 
ATOM   5414  C C   . GLY B 1 193 ? -0.098  54.434  -40.955 1.00 48.86  ? 193 GLY B C   1 
ATOM   5415  O O   . GLY B 1 193 ? -0.618  55.361  -41.573 1.00 46.74  ? 193 GLY B O   1 
ATOM   5416  N N   . THR B 1 194 ? 1.222   54.272  -40.808 1.00 48.33  ? 194 THR B N   1 
ATOM   5417  C CA  . THR B 1 194 ? 2.191   55.272  -41.211 1.00 49.85  ? 194 THR B CA  1 
ATOM   5418  C C   . THR B 1 194 ? 3.170   54.635  -42.195 1.00 51.75  ? 194 THR B C   1 
ATOM   5419  O O   . THR B 1 194 ? 3.505   53.458  -42.063 1.00 46.54  ? 194 THR B O   1 
ATOM   5420  C CB  . THR B 1 194 ? 2.898   55.844  -39.976 1.00 52.46  ? 194 THR B CB  1 
ATOM   5421  O OG1 . THR B 1 194 ? 1.917   56.487  -39.163 1.00 54.03  ? 194 THR B OG1 1 
ATOM   5422  C CG2 . THR B 1 194 ? 3.941   56.882  -40.344 1.00 51.84  ? 194 THR B CG2 1 
ATOM   5423  N N   . SER B 1 195 ? 3.563   55.436  -43.201 1.00 50.02  ? 195 SER B N   1 
ATOM   5424  C CA  . SER B 1 195 ? 4.553   55.087  -44.208 1.00 51.05  ? 195 SER B CA  1 
ATOM   5425  C C   . SER B 1 195 ? 4.005   54.044  -45.189 1.00 50.86  ? 195 SER B C   1 
ATOM   5426  O O   . SER B 1 195 ? 4.795   53.410  -45.894 1.00 47.19  ? 195 SER B O   1 
ATOM   5427  C CB  . SER B 1 195 ? 5.837   54.596  -43.564 1.00 59.82  ? 195 SER B CB  1 
ATOM   5428  O OG  . SER B 1 195 ? 6.350   55.481  -42.581 1.00 59.92  ? 195 SER B OG  1 
ATOM   5429  N N   . LEU B 1 196 ? 2.667   53.895  -45.243 1.00 50.35  ? 196 LEU B N   1 
ATOM   5430  C CA  . LEU B 1 196 ? 2.000   52.791  -45.920 1.00 50.56  ? 196 LEU B CA  1 
ATOM   5431  C C   . LEU B 1 196 ? 2.442   52.723  -47.383 1.00 55.97  ? 196 LEU B C   1 
ATOM   5432  O O   . LEU B 1 196 ? 2.811   51.650  -47.856 1.00 52.16  ? 196 LEU B O   1 
ATOM   5433  C CB  . LEU B 1 196 ? 0.479   52.893  -45.827 1.00 50.05  ? 196 LEU B CB  1 
ATOM   5434  C CG  . LEU B 1 196 ? -0.131  52.894  -44.422 1.00 56.79  ? 196 LEU B CG  1 
ATOM   5435  C CD1 . LEU B 1 196 ? -1.668  52.862  -44.446 1.00 56.84  ? 196 LEU B CD1 1 
ATOM   5436  C CD2 . LEU B 1 196 ? 0.417   51.745  -43.607 1.00 60.88  ? 196 LEU B CD2 1 
ATOM   5437  N N   . PRO B 1 197 ? 2.475   53.852  -48.139 1.00 58.89  ? 197 PRO B N   1 
ATOM   5438  C CA  . PRO B 1 197 ? 2.933   53.828  -49.531 1.00 49.87  ? 197 PRO B CA  1 
ATOM   5439  C C   . PRO B 1 197 ? 4.395   53.465  -49.755 1.00 46.10  ? 197 PRO B C   1 
ATOM   5440  O O   . PRO B 1 197 ? 4.805   53.342  -50.903 1.00 50.46  ? 197 PRO B O   1 
ATOM   5441  C CB  . PRO B 1 197 ? 2.673   55.262  -50.021 1.00 51.78  ? 197 PRO B CB  1 
ATOM   5442  C CG  . PRO B 1 197 ? 1.712   55.826  -49.028 1.00 57.93  ? 197 PRO B CG  1 
ATOM   5443  C CD  . PRO B 1 197 ? 2.100   55.206  -47.700 1.00 55.36  ? 197 PRO B CD  1 
ATOM   5444  N N   . PHE B 1 198 ? 5.183   53.341  -48.674 1.00 47.16  ? 198 PHE B N   1 
ATOM   5445  C CA  . PHE B 1 198 ? 6.638   53.288  -48.761 1.00 46.61  ? 198 PHE B CA  1 
ATOM   5446  C C   . PHE B 1 198 ? 7.182   51.996  -48.149 1.00 48.72  ? 198 PHE B C   1 
ATOM   5447  O O   . PHE B 1 198 ? 8.398   51.873  -47.947 1.00 49.17  ? 198 PHE B O   1 
ATOM   5448  C CB  . PHE B 1 198 ? 7.191   54.541  -48.064 1.00 50.39  ? 198 PHE B CB  1 
ATOM   5449  C CG  . PHE B 1 198 ? 6.624   55.848  -48.615 1.00 52.07  ? 198 PHE B CG  1 
ATOM   5450  C CD1 . PHE B 1 198 ? 6.980   56.310  -49.882 1.00 55.24  ? 198 PHE B CD1 1 
ATOM   5451  C CD2 . PHE B 1 198 ? 5.729   56.605  -47.874 1.00 48.81  ? 198 PHE B CD2 1 
ATOM   5452  C CE1 . PHE B 1 198 ? 6.446   57.491  -50.385 1.00 60.19  ? 198 PHE B CE1 1 
ATOM   5453  C CE2 . PHE B 1 198 ? 5.203   57.793  -48.378 1.00 56.53  ? 198 PHE B CE2 1 
ATOM   5454  C CZ  . PHE B 1 198 ? 5.568   58.240  -49.627 1.00 53.89  ? 198 PHE B CZ  1 
ATOM   5455  N N   . VAL B 1 199 ? 6.292   51.038  -47.842 1.00 45.12  ? 199 VAL B N   1 
ATOM   5456  C CA  . VAL B 1 199 ? 6.730   49.739  -47.346 1.00 49.65  ? 199 VAL B CA  1 
ATOM   5457  C C   . VAL B 1 199 ? 6.298   48.650  -48.333 1.00 49.82  ? 199 VAL B C   1 
ATOM   5458  O O   . VAL B 1 199 ? 5.500   48.891  -49.238 1.00 54.68  ? 199 VAL B O   1 
ATOM   5459  C CB  . VAL B 1 199 ? 6.229   49.473  -45.909 1.00 47.72  ? 199 VAL B CB  1 
ATOM   5460  C CG1 . VAL B 1 199 ? 6.771   50.516  -44.937 1.00 49.71  ? 199 VAL B CG1 1 
ATOM   5461  C CG2 . VAL B 1 199 ? 4.709   49.361  -45.805 1.00 40.97  ? 199 VAL B CG2 1 
ATOM   5462  N N   . ASN B 1 200 ? 6.849   47.446  -48.158 1.00 51.02  ? 200 ASN B N   1 
ATOM   5463  C CA  . ASN B 1 200 ? 6.521   46.311  -49.009 1.00 45.22  ? 200 ASN B CA  1 
ATOM   5464  C C   . ASN B 1 200 ? 5.323   45.551  -48.452 1.00 47.75  ? 200 ASN B C   1 
ATOM   5465  O O   . ASN B 1 200 ? 4.497   45.052  -49.216 1.00 42.27  ? 200 ASN B O   1 
ATOM   5466  C CB  . ASN B 1 200 ? 7.725   45.405  -49.153 1.00 43.65  ? 200 ASN B CB  1 
ATOM   5467  C CG  . ASN B 1 200 ? 8.919   46.204  -49.618 1.00 50.52  ? 200 ASN B CG  1 
ATOM   5468  O OD1 . ASN B 1 200 ? 9.914   46.338  -48.889 1.00 46.61  ? 200 ASN B OD1 1 
ATOM   5469  N ND2 . ASN B 1 200 ? 8.804   46.795  -50.800 1.00 51.48  ? 200 ASN B ND2 1 
ATOM   5470  N N   . GLU B 1 201 ? 5.220   45.483  -47.118 1.00 52.34  ? 201 GLU B N   1 
ATOM   5471  C CA  . GLU B 1 201 ? 4.250   44.609  -46.471 1.00 56.39  ? 201 GLU B CA  1 
ATOM   5472  C C   . GLU B 1 201 ? 3.696   45.301  -45.226 1.00 53.45  ? 201 GLU B C   1 
ATOM   5473  O O   . GLU B 1 201 ? 4.415   46.021  -44.545 1.00 53.89  ? 201 GLU B O   1 
ATOM   5474  C CB  . GLU B 1 201 ? 4.877   43.255  -46.104 1.00 57.54  ? 201 GLU B CB  1 
ATOM   5475  C CG  . GLU B 1 201 ? 5.337   42.419  -47.299 1.00 60.82  ? 201 GLU B CG  1 
ATOM   5476  C CD  . GLU B 1 201 ? 6.092   41.125  -46.993 1.00 60.40  ? 201 GLU B CD  1 
ATOM   5477  O OE1 . GLU B 1 201 ? 6.157   40.735  -45.816 1.00 61.52  ? 201 GLU B OE1 1 
ATOM   5478  O OE2 . GLU B 1 201 ? 6.647   40.511  -47.931 1.00 55.99  ? 201 GLU B OE2 1 
ATOM   5479  N N   . LEU B 1 202 ? 2.416   45.047  -44.933 1.00 52.82  ? 202 LEU B N   1 
ATOM   5480  C CA  . LEU B 1 202 ? 1.782   45.489  -43.704 1.00 46.77  ? 202 LEU B CA  1 
ATOM   5481  C C   . LEU B 1 202 ? 1.765   44.381  -42.642 1.00 53.51  ? 202 LEU B C   1 
ATOM   5482  O O   . LEU B 1 202 ? 1.578   43.195  -42.962 1.00 47.68  ? 202 LEU B O   1 
ATOM   5483  C CB  . LEU B 1 202 ? 0.370   45.905  -44.073 1.00 46.41  ? 202 LEU B CB  1 
ATOM   5484  C CG  . LEU B 1 202 ? 0.233   47.017  -45.105 1.00 49.86  ? 202 LEU B CG  1 
ATOM   5485  C CD1 . LEU B 1 202 ? -1.252  47.162  -45.368 1.00 47.58  ? 202 LEU B CD1 1 
ATOM   5486  C CD2 . LEU B 1 202 ? 0.858   48.332  -44.654 1.00 50.51  ? 202 LEU B CD2 1 
ATOM   5487  N N   . LEU B 1 203 ? 1.955   44.799  -41.372 1.00 48.18  ? 203 LEU B N   1 
ATOM   5488  C CA  . LEU B 1 203 ? 1.693   43.985  -40.191 1.00 46.54  ? 203 LEU B CA  1 
ATOM   5489  C C   . LEU B 1 203 ? 0.309   44.314  -39.631 1.00 47.90  ? 203 LEU B C   1 
ATOM   5490  O O   . LEU B 1 203 ? 0.161   45.200  -38.801 1.00 52.30  ? 203 LEU B O   1 
ATOM   5491  C CB  . LEU B 1 203 ? 2.791   44.246  -39.164 1.00 47.88  ? 203 LEU B CB  1 
ATOM   5492  C CG  . LEU B 1 203 ? 4.167   43.697  -39.536 1.00 50.48  ? 203 LEU B CG  1 
ATOM   5493  C CD1 . LEU B 1 203 ? 5.322   44.317  -38.763 1.00 52.58  ? 203 LEU B CD1 1 
ATOM   5494  C CD2 . LEU B 1 203 ? 4.135   42.195  -39.330 1.00 53.25  ? 203 LEU B CD2 1 
ATOM   5495  N N   . VAL B 1 204 ? -0.721  43.607  -40.094 1.00 50.98  ? 204 VAL B N   1 
ATOM   5496  C CA  . VAL B 1 204 ? -2.064  43.845  -39.599 1.00 54.44  ? 204 VAL B CA  1 
ATOM   5497  C C   . VAL B 1 204 ? -2.210  43.214  -38.215 1.00 56.38  ? 204 VAL B C   1 
ATOM   5498  O O   . VAL B 1 204 ? -1.598  42.189  -37.943 1.00 58.54  ? 204 VAL B O   1 
ATOM   5499  C CB  . VAL B 1 204 ? -3.086  43.301  -40.609 1.00 56.98  ? 204 VAL B CB  1 
ATOM   5500  C CG1 . VAL B 1 204 ? -4.513  43.440  -40.097 1.00 62.35  ? 204 VAL B CG1 1 
ATOM   5501  C CG2 . VAL B 1 204 ? -2.921  43.978  -41.965 1.00 54.91  ? 204 VAL B CG2 1 
ATOM   5502  N N   . GLY B 1 205 ? -3.026  43.844  -37.357 1.00 59.09  ? 205 GLY B N   1 
ATOM   5503  C CA  . GLY B 1 205 ? -3.223  43.421  -35.978 1.00 58.53  ? 205 GLY B CA  1 
ATOM   5504  C C   . GLY B 1 205 ? -4.389  44.165  -35.321 1.00 58.54  ? 205 GLY B C   1 
ATOM   5505  O O   . GLY B 1 205 ? -5.011  45.012  -35.952 1.00 58.64  ? 205 GLY B O   1 
ATOM   5506  N N   . ASN B 1 206 ? -4.684  43.810  -34.062 1.00 56.94  ? 206 ASN B N   1 
ATOM   5507  C CA  . ASN B 1 206 ? -5.727  44.443  -33.272 1.00 63.89  ? 206 ASN B CA  1 
ATOM   5508  C C   . ASN B 1 206 ? -5.206  44.742  -31.865 1.00 62.27  ? 206 ASN B C   1 
ATOM   5509  O O   . ASN B 1 206 ? -4.353  44.011  -31.345 1.00 49.38  ? 206 ASN B O   1 
ATOM   5510  C CB  . ASN B 1 206 ? -6.974  43.573  -33.145 1.00 69.52  ? 206 ASN B CB  1 
ATOM   5511  C CG  . ASN B 1 206 ? -7.479  43.074  -34.480 1.00 70.90  ? 206 ASN B CG  1 
ATOM   5512  O OD1 . ASN B 1 206 ? -7.052  42.015  -34.951 1.00 64.97  ? 206 ASN B OD1 1 
ATOM   5513  N ND2 . ASN B 1 206 ? -8.434  43.777  -35.070 1.00 69.57  ? 206 ASN B ND2 1 
ATOM   5514  N N   . LEU B 1 207 ? -5.711  45.847  -31.292 1.00 60.62  ? 207 LEU B N   1 
ATOM   5515  C CA  . LEU B 1 207 ? -5.699  46.092  -29.855 1.00 65.92  ? 207 LEU B CA  1 
ATOM   5516  C C   . LEU B 1 207 ? -7.120  45.872  -29.345 1.00 64.14  ? 207 LEU B C   1 
ATOM   5517  O O   . LEU B 1 207 ? -8.057  46.438  -29.896 1.00 66.19  ? 207 LEU B O   1 
ATOM   5518  C CB  . LEU B 1 207 ? -5.231  47.501  -29.491 1.00 74.78  ? 207 LEU B CB  1 
ATOM   5519  C CG  . LEU B 1 207 ? -3.756  47.853  -29.731 1.00 76.81  ? 207 LEU B CG  1 
ATOM   5520  C CD1 . LEU B 1 207 ? -2.785  46.787  -29.271 1.00 76.63  ? 207 LEU B CD1 1 
ATOM   5521  C CD2 . LEU B 1 207 ? -3.533  48.178  -31.182 1.00 82.65  ? 207 LEU B CD2 1 
ATOM   5522  N N   . TRP B 1 208 ? -7.280  45.039  -28.312 1.00 60.02  ? 208 TRP B N   1 
ATOM   5523  C CA  . TRP B 1 208 ? -8.602  44.614  -27.884 1.00 63.00  ? 208 TRP B CA  1 
ATOM   5524  C C   . TRP B 1 208 ? -9.502  45.821  -27.607 1.00 64.42  ? 208 TRP B C   1 
ATOM   5525  O O   . TRP B 1 208 ? -9.085  46.760  -26.945 1.00 56.77  ? 208 TRP B O   1 
ATOM   5526  C CB  . TRP B 1 208 ? -8.523  43.717  -26.640 1.00 61.92  ? 208 TRP B CB  1 
ATOM   5527  C CG  . TRP B 1 208 ? -9.891  43.296  -26.158 1.00 68.57  ? 208 TRP B CG  1 
ATOM   5528  C CD1 . TRP B 1 208 ? -10.639 42.270  -26.655 1.00 71.03  ? 208 TRP B CD1 1 
ATOM   5529  C CD2 . TRP B 1 208 ? -10.692 43.908  -25.116 1.00 70.33  ? 208 TRP B CD2 1 
ATOM   5530  N NE1 . TRP B 1 208 ? -11.833 42.183  -25.990 1.00 75.06  ? 208 TRP B NE1 1 
ATOM   5531  C CE2 . TRP B 1 208 ? -11.899 43.172  -25.043 1.00 74.57  ? 208 TRP B CE2 1 
ATOM   5532  C CE3 . TRP B 1 208 ? -10.511 44.992  -24.241 1.00 68.58  ? 208 TRP B CE3 1 
ATOM   5533  C CZ2 . TRP B 1 208 ? -12.910 43.482  -24.131 1.00 77.52  ? 208 TRP B CZ2 1 
ATOM   5534  C CZ3 . TRP B 1 208 ? -11.513 45.301  -23.345 1.00 72.59  ? 208 TRP B CZ3 1 
ATOM   5535  C CH2 . TRP B 1 208 ? -12.695 44.555  -23.291 1.00 78.64  ? 208 TRP B CH2 1 
ATOM   5536  N N   . ARG B 1 209 ? -10.731 45.759  -28.128 1.00 70.67  ? 209 ARG B N   1 
ATOM   5537  C CA  . ARG B 1 209 ? -11.807 46.691  -27.829 1.00 86.56  ? 209 ARG B CA  1 
ATOM   5538  C C   . ARG B 1 209 ? -12.964 45.862  -27.281 1.00 79.97  ? 209 ARG B C   1 
ATOM   5539  O O   . ARG B 1 209 ? -13.103 44.694  -27.624 1.00 79.41  ? 209 ARG B O   1 
ATOM   5540  C CB  . ARG B 1 209 ? -12.399 47.388  -29.066 1.00 100.64 ? 209 ARG B CB  1 
ATOM   5541  C CG  . ARG B 1 209 ? -11.429 47.989  -30.074 1.00 118.29 ? 209 ARG B CG  1 
ATOM   5542  C CD  . ARG B 1 209 ? -10.921 49.375  -29.685 1.00 131.11 ? 209 ARG B CD  1 
ATOM   5543  N NE  . ARG B 1 209 ? -9.583  49.642  -30.236 1.00 138.63 ? 209 ARG B NE  1 
ATOM   5544  C CZ  . ARG B 1 209 ? -9.258  50.464  -31.237 1.00 124.98 ? 209 ARG B CZ  1 
ATOM   5545  N NH1 . ARG B 1 209 ? -10.196 51.100  -31.920 1.00 126.66 ? 209 ARG B NH1 1 
ATOM   5546  N NH2 . ARG B 1 209 ? -7.985  50.630  -31.560 1.00 105.87 ? 209 ARG B NH2 1 
ATOM   5547  N N   . PRO B 1 210 ? -13.831 46.398  -26.403 1.00 81.13  ? 210 PRO B N   1 
ATOM   5548  C CA  . PRO B 1 210 ? -15.064 45.685  -26.050 1.00 79.74  ? 210 PRO B CA  1 
ATOM   5549  C C   . PRO B 1 210 ? -15.932 45.287  -27.249 1.00 70.84  ? 210 PRO B C   1 
ATOM   5550  O O   . PRO B 1 210 ? -16.113 46.066  -28.174 1.00 69.77  ? 210 PRO B O   1 
ATOM   5551  C CB  . PRO B 1 210 ? -15.745 46.705  -25.109 1.00 81.87  ? 210 PRO B CB  1 
ATOM   5552  C CG  . PRO B 1 210 ? -14.586 47.432  -24.461 1.00 79.59  ? 210 PRO B CG  1 
ATOM   5553  C CD  . PRO B 1 210 ? -13.609 47.620  -25.613 1.00 80.74  ? 210 PRO B CD  1 
ATOM   5554  N N   . GLY B 1 211 ? -16.431 44.043  -27.252 1.00 80.41  ? 211 GLY B N   1 
ATOM   5555  C CA  . GLY B 1 211 ? -17.320 43.566  -28.302 1.00 79.72  ? 211 GLY B CA  1 
ATOM   5556  C C   . GLY B 1 211 ? -16.573 43.000  -29.511 1.00 82.23  ? 211 GLY B C   1 
ATOM   5557  O O   . GLY B 1 211 ? -17.212 42.537  -30.457 1.00 86.02  ? 211 GLY B O   1 
ATOM   5558  N N   . GLN B 1 212 ? -15.228 43.034  -29.470 1.00 76.48  ? 212 GLN B N   1 
ATOM   5559  C CA  . GLN B 1 212 ? -14.384 42.455  -30.508 1.00 72.86  ? 212 GLN B CA  1 
ATOM   5560  C C   . GLN B 1 212 ? -14.680 40.964  -30.648 1.00 72.01  ? 212 GLN B C   1 
ATOM   5561  O O   . GLN B 1 212 ? -14.520 40.214  -29.688 1.00 71.97  ? 212 GLN B O   1 
ATOM   5562  C CB  . GLN B 1 212 ? -12.896 42.624  -30.186 1.00 72.86  ? 212 GLN B CB  1 
ATOM   5563  C CG  . GLN B 1 212 ? -11.954 42.060  -31.247 1.00 69.32  ? 212 GLN B CG  1 
ATOM   5564  C CD  . GLN B 1 212 ? -10.539 42.599  -31.158 1.00 71.02  ? 212 GLN B CD  1 
ATOM   5565  O OE1 . GLN B 1 212 ? -10.310 43.807  -31.019 1.00 82.25  ? 212 GLN B OE1 1 
ATOM   5566  N NE2 . GLN B 1 212 ? -9.564  41.706  -31.270 1.00 68.36  ? 212 GLN B NE2 1 
ATOM   5567  N N   . THR B 1 213 ? -15.087 40.551  -31.858 1.00 71.97  ? 213 THR B N   1 
ATOM   5568  C CA  . THR B 1 213 ? -15.438 39.167  -32.129 1.00 63.48  ? 213 THR B CA  1 
ATOM   5569  C C   . THR B 1 213 ? -14.184 38.397  -32.531 1.00 64.38  ? 213 THR B C   1 
ATOM   5570  O O   . THR B 1 213 ? -13.096 38.959  -32.666 1.00 66.48  ? 213 THR B O   1 
ATOM   5571  C CB  . THR B 1 213 ? -16.505 39.085  -33.225 1.00 64.04  ? 213 THR B CB  1 
ATOM   5572  O OG1 . THR B 1 213 ? -15.807 39.412  -34.424 1.00 55.02  ? 213 THR B OG1 1 
ATOM   5573  C CG2 . THR B 1 213 ? -17.718 39.970  -32.968 1.00 61.68  ? 213 THR B CG2 1 
ATOM   5574  N N   . SER B 1 214 ? -14.377 37.092  -32.743 1.00 64.70  ? 214 SER B N   1 
ATOM   5575  C CA  . SER B 1 214 ? -13.320 36.162  -33.112 1.00 58.64  ? 214 SER B CA  1 
ATOM   5576  C C   . SER B 1 214 ? -12.877 36.414  -34.554 1.00 51.26  ? 214 SER B C   1 
ATOM   5577  O O   . SER B 1 214 ? -11.683 36.447  -34.841 1.00 44.91  ? 214 SER B O   1 
ATOM   5578  C CB  . SER B 1 214 ? -13.809 34.732  -32.902 1.00 58.62  ? 214 SER B CB  1 
ATOM   5579  O OG  . SER B 1 214 ? -12.895 33.778  -33.412 1.00 57.11  ? 214 SER B OG  1 
ATOM   5580  N N   . ASP B 1 215 ? -13.867 36.604  -35.440 1.00 52.58  ? 215 ASP B N   1 
ATOM   5581  C CA  . ASP B 1 215 ? -13.673 36.920  -36.850 1.00 58.62  ? 215 ASP B CA  1 
ATOM   5582  C C   . ASP B 1 215 ? -12.915 38.240  -37.039 1.00 58.01  ? 215 ASP B C   1 
ATOM   5583  O O   . ASP B 1 215 ? -12.292 38.422  -38.086 1.00 52.84  ? 215 ASP B O   1 
ATOM   5584  C CB  . ASP B 1 215 ? -15.003 36.904  -37.600 1.00 67.77  ? 215 ASP B CB  1 
ATOM   5585  C CG  . ASP B 1 215 ? -15.564 35.539  -38.009 1.00 65.81  ? 215 ASP B CG  1 
ATOM   5586  O OD1 . ASP B 1 215 ? -14.788 34.551  -38.089 1.00 59.70  ? 215 ASP B OD1 1 
ATOM   5587  O OD2 . ASP B 1 215 ? -16.787 35.468  -38.252 1.00 61.19  ? 215 ASP B OD2 1 
ATOM   5588  N N   . GLN B 1 216 ? -12.952 39.135  -36.028 1.00 60.40  ? 216 GLN B N   1 
ATOM   5589  C CA  . GLN B 1 216 ? -12.276 40.427  -36.081 1.00 61.11  ? 216 GLN B CA  1 
ATOM   5590  C C   . GLN B 1 216 ? -10.863 40.365  -35.498 1.00 54.75  ? 216 GLN B C   1 
ATOM   5591  O O   . GLN B 1 216 ? -10.158 41.369  -35.498 1.00 61.79  ? 216 GLN B O   1 
ATOM   5592  C CB  . GLN B 1 216 ? -13.049 41.508  -35.321 1.00 58.07  ? 216 GLN B CB  1 
ATOM   5593  C CG  . GLN B 1 216 ? -14.383 41.873  -35.957 1.00 59.17  ? 216 GLN B CG  1 
ATOM   5594  C CD  . GLN B 1 216 ? -15.306 42.657  -35.044 1.00 57.56  ? 216 GLN B CD  1 
ATOM   5595  O OE1 . GLN B 1 216 ? -15.003 42.938  -33.881 1.00 60.27  ? 216 GLN B OE1 1 
ATOM   5596  N NE2 . GLN B 1 216 ? -16.469 43.010  -35.564 1.00 57.38  ? 216 GLN B NE2 1 
ATOM   5597  N N   . THR B 1 217 ? -10.439 39.216  -34.970 1.00 48.61  ? 217 THR B N   1 
ATOM   5598  C CA  . THR B 1 217 ? -9.084  39.124  -34.445 1.00 52.86  ? 217 THR B CA  1 
ATOM   5599  C C   . THR B 1 217 ? -8.175  38.529  -35.527 1.00 56.52  ? 217 THR B C   1 
ATOM   5600  O O   . THR B 1 217 ? -8.248  37.339  -35.834 1.00 53.51  ? 217 THR B O   1 
ATOM   5601  C CB  . THR B 1 217 ? -9.085  38.333  -33.135 1.00 50.78  ? 217 THR B CB  1 
ATOM   5602  O OG1 . THR B 1 217 ? -10.134 38.899  -32.354 1.00 51.28  ? 217 THR B OG1 1 
ATOM   5603  C CG2 . THR B 1 217 ? -7.776  38.434  -32.366 1.00 51.02  ? 217 THR B CG2 1 
ATOM   5604  N N   . VAL B 1 218 ? -7.352  39.389  -36.146 1.00 60.90  ? 218 VAL B N   1 
ATOM   5605  C CA  . VAL B 1 218 ? -6.471  38.969  -37.225 1.00 59.80  ? 218 VAL B CA  1 
ATOM   5606  C C   . VAL B 1 218 ? -5.097  39.614  -37.087 1.00 55.18  ? 218 VAL B C   1 
ATOM   5607  O O   . VAL B 1 218 ? -4.995  40.841  -37.062 1.00 56.61  ? 218 VAL B O   1 
ATOM   5608  C CB  . VAL B 1 218 ? -7.083  39.331  -38.585 1.00 61.71  ? 218 VAL B CB  1 
ATOM   5609  C CG1 . VAL B 1 218 ? -6.124  38.984  -39.724 1.00 60.02  ? 218 VAL B CG1 1 
ATOM   5610  C CG2 . VAL B 1 218 ? -8.442  38.668  -38.773 1.00 63.72  ? 218 VAL B CG2 1 
ATOM   5611  N N   . TYR B 1 219 ? -4.058  38.763  -37.060 1.00 52.68  ? 219 TYR B N   1 
ATOM   5612  C CA  . TYR B 1 219 ? -2.665  39.186  -37.075 1.00 56.06  ? 219 TYR B CA  1 
ATOM   5613  C C   . TYR B 1 219 ? -1.986  38.516  -38.259 1.00 54.60  ? 219 TYR B C   1 
ATOM   5614  O O   . TYR B 1 219 ? -1.970  37.296  -38.321 1.00 55.19  ? 219 TYR B O   1 
ATOM   5615  C CB  . TYR B 1 219 ? -1.952  38.806  -35.778 1.00 56.44  ? 219 TYR B CB  1 
ATOM   5616  C CG  . TYR B 1 219 ? -2.605  39.451  -34.570 1.00 60.72  ? 219 TYR B CG  1 
ATOM   5617  C CD1 . TYR B 1 219 ? -3.759  38.911  -33.995 1.00 51.87  ? 219 TYR B CD1 1 
ATOM   5618  C CD2 . TYR B 1 219 ? -2.080  40.624  -34.033 1.00 56.05  ? 219 TYR B CD2 1 
ATOM   5619  C CE1 . TYR B 1 219 ? -4.368  39.523  -32.912 1.00 51.79  ? 219 TYR B CE1 1 
ATOM   5620  C CE2 . TYR B 1 219 ? -2.672  41.232  -32.940 1.00 51.23  ? 219 TYR B CE2 1 
ATOM   5621  C CZ  . TYR B 1 219 ? -3.822  40.692  -32.397 1.00 53.27  ? 219 TYR B CZ  1 
ATOM   5622  O OH  . TYR B 1 219 ? -4.359  41.337  -31.332 1.00 53.25  ? 219 TYR B OH  1 
ATOM   5623  N N   . ALA B 1 220 ? -1.460  39.310  -39.200 1.00 51.88  ? 220 ALA B N   1 
ATOM   5624  C CA  . ALA B 1 220 ? -0.960  38.759  -40.450 1.00 55.26  ? 220 ALA B CA  1 
ATOM   5625  C C   . ALA B 1 220 ? -0.074  39.771  -41.164 1.00 53.53  ? 220 ALA B C   1 
ATOM   5626  O O   . ALA B 1 220 ? -0.309  40.972  -41.050 1.00 53.97  ? 220 ALA B O   1 
ATOM   5627  C CB  . ALA B 1 220 ? -2.113  38.336  -41.347 1.00 53.23  ? 220 ALA B CB  1 
ATOM   5628  N N   . ILE B 1 221 ? 0.921   39.245  -41.894 1.00 55.28  ? 221 ILE B N   1 
ATOM   5629  C CA  . ILE B 1 221 ? 1.664   39.983  -42.907 1.00 56.25  ? 221 ILE B CA  1 
ATOM   5630  C C   . ILE B 1 221 ? 0.853   40.020  -44.202 1.00 55.09  ? 221 ILE B C   1 
ATOM   5631  O O   . ILE B 1 221 ? 0.356   38.990  -44.642 1.00 58.79  ? 221 ILE B O   1 
ATOM   5632  C CB  . ILE B 1 221 ? 3.041   39.349  -43.146 1.00 58.80  ? 221 ILE B CB  1 
ATOM   5633  C CG1 . ILE B 1 221 ? 3.861   39.322  -41.874 1.00 68.07  ? 221 ILE B CG1 1 
ATOM   5634  C CG2 . ILE B 1 221 ? 3.773   40.069  -44.274 1.00 67.42  ? 221 ILE B CG2 1 
ATOM   5635  C CD1 . ILE B 1 221 ? 5.340   39.033  -42.083 1.00 70.78  ? 221 ILE B CD1 1 
ATOM   5636  N N   . VAL B 1 222 ? 0.722   41.215  -44.800 1.00 54.10  ? 222 VAL B N   1 
ATOM   5637  C CA  . VAL B 1 222 ? -0.019  41.400  -46.047 1.00 55.56  ? 222 VAL B CA  1 
ATOM   5638  C C   . VAL B 1 222 ? 0.797   42.288  -46.993 1.00 55.61  ? 222 VAL B C   1 
ATOM   5639  O O   . VAL B 1 222 ? 1.014   43.463  -46.699 1.00 52.47  ? 222 VAL B O   1 
ATOM   5640  C CB  . VAL B 1 222 ? -1.422  42.007  -45.856 1.00 51.96  ? 222 VAL B CB  1 
ATOM   5641  C CG1 . VAL B 1 222 ? -2.200  42.088  -47.168 1.00 48.56  ? 222 VAL B CG1 1 
ATOM   5642  C CG2 . VAL B 1 222 ? -2.227  41.266  -44.797 1.00 56.59  ? 222 VAL B CG2 1 
ATOM   5643  N N   . PRO B 1 223 ? 1.253   41.772  -48.164 1.00 55.57  ? 223 PRO B N   1 
ATOM   5644  C CA  . PRO B 1 223 ? 1.961   42.609  -49.141 1.00 53.29  ? 223 PRO B CA  1 
ATOM   5645  C C   . PRO B 1 223 ? 1.126   43.825  -49.532 1.00 49.50  ? 223 PRO B C   1 
ATOM   5646  O O   . PRO B 1 223 ? -0.087  43.696  -49.670 1.00 48.95  ? 223 PRO B O   1 
ATOM   5647  C CB  . PRO B 1 223 ? 2.187   41.635  -50.332 1.00 55.08  ? 223 PRO B CB  1 
ATOM   5648  C CG  . PRO B 1 223 ? 2.217   40.257  -49.684 1.00 55.83  ? 223 PRO B CG  1 
ATOM   5649  C CD  . PRO B 1 223 ? 1.136   40.362  -48.598 1.00 53.24  ? 223 PRO B CD  1 
ATOM   5650  N N   . VAL B 1 224 ? 1.772   44.983  -49.748 1.00 49.86  ? 224 VAL B N   1 
ATOM   5651  C CA  . VAL B 1 224 ? 1.052   46.222  -50.064 1.00 56.76  ? 224 VAL B CA  1 
ATOM   5652  C C   . VAL B 1 224 ? 0.341   46.120  -51.425 1.00 52.79  ? 224 VAL B C   1 
ATOM   5653  O O   . VAL B 1 224 ? -0.720  46.713  -51.595 1.00 52.98  ? 224 VAL B O   1 
ATOM   5654  C CB  . VAL B 1 224 ? 1.932   47.494  -49.954 1.00 57.87  ? 224 VAL B CB  1 
ATOM   5655  C CG1 . VAL B 1 224 ? 1.262   48.761  -50.485 1.00 56.52  ? 224 VAL B CG1 1 
ATOM   5656  C CG2 . VAL B 1 224 ? 2.371   47.738  -48.515 1.00 59.86  ? 224 VAL B CG2 1 
ATOM   5657  N N   . ASN B 1 225 ? 0.859   45.323  -52.372 1.00 58.46  ? 225 ASN B N   1 
ATOM   5658  C CA  . ASN B 1 225 ? 0.239   45.220  -53.692 1.00 64.46  ? 225 ASN B CA  1 
ATOM   5659  C C   . ASN B 1 225 ? -0.652  43.981  -53.832 1.00 63.71  ? 225 ASN B C   1 
ATOM   5660  O O   . ASN B 1 225 ? -0.898  43.530  -54.946 1.00 66.52  ? 225 ASN B O   1 
ATOM   5661  C CB  . ASN B 1 225 ? 1.275   45.193  -54.806 1.00 60.86  ? 225 ASN B CB  1 
ATOM   5662  C CG  . ASN B 1 225 ? 2.121   43.946  -54.733 1.00 59.75  ? 225 ASN B CG  1 
ATOM   5663  O OD1 . ASN B 1 225 ? 2.090   43.238  -53.716 1.00 61.21  ? 225 ASN B OD1 1 
ATOM   5664  N ND2 . ASN B 1 225 ? 2.887   43.681  -55.780 1.00 55.42  ? 225 ASN B ND2 1 
ATOM   5665  N N   . THR B 1 226 ? -1.162  43.454  -52.717 1.00 59.40  ? 226 THR B N   1 
ATOM   5666  C CA  . THR B 1 226 ? -2.109  42.354  -52.753 1.00 60.22  ? 226 THR B CA  1 
ATOM   5667  C C   . THR B 1 226 ? -3.375  42.817  -53.476 1.00 57.22  ? 226 THR B C   1 
ATOM   5668  O O   . THR B 1 226 ? -3.842  43.939  -53.247 1.00 54.99  ? 226 THR B O   1 
ATOM   5669  C CB  . THR B 1 226 ? -2.416  41.873  -51.330 1.00 58.81  ? 226 THR B CB  1 
ATOM   5670  O OG1 . THR B 1 226 ? -1.181  41.483  -50.739 1.00 62.70  ? 226 THR B OG1 1 
ATOM   5671  C CG2 . THR B 1 226 ? -3.367  40.693  -51.304 1.00 57.39  ? 226 THR B CG2 1 
ATOM   5672  N N   . PRO B 1 227 ? -3.958  41.973  -54.367 1.00 61.82  ? 227 PRO B N   1 
ATOM   5673  C CA  . PRO B 1 227 ? -5.235  42.290  -55.017 1.00 66.54  ? 227 PRO B CA  1 
ATOM   5674  C C   . PRO B 1 227 ? -6.335  42.632  -54.012 1.00 63.29  ? 227 PRO B C   1 
ATOM   5675  O O   . PRO B 1 227 ? -6.547  41.891  -53.047 1.00 65.21  ? 227 PRO B O   1 
ATOM   5676  C CB  . PRO B 1 227 ? -5.542  41.014  -55.845 1.00 56.17  ? 227 PRO B CB  1 
ATOM   5677  C CG  . PRO B 1 227 ? -4.165  40.475  -56.153 1.00 58.91  ? 227 PRO B CG  1 
ATOM   5678  C CD  . PRO B 1 227 ? -3.389  40.704  -54.862 1.00 60.06  ? 227 PRO B CD  1 
ATOM   5679  N N   . GLY B 1 228 ? -6.989  43.781  -54.241 1.00 58.46  ? 228 GLY B N   1 
ATOM   5680  C CA  . GLY B 1 228 ? -8.111  44.237  -53.431 1.00 57.19  ? 228 GLY B CA  1 
ATOM   5681  C C   . GLY B 1 228 ? -7.707  45.162  -52.273 1.00 51.99  ? 228 GLY B C   1 
ATOM   5682  O O   . GLY B 1 228 ? -8.591  45.672  -51.586 1.00 50.75  ? 228 GLY B O   1 
ATOM   5683  N N   . LEU B 1 229 ? -6.395  45.347  -52.033 1.00 52.57  ? 229 LEU B N   1 
ATOM   5684  C CA  . LEU B 1 229 ? -5.911  46.267  -51.003 1.00 54.24  ? 229 LEU B CA  1 
ATOM   5685  C C   . LEU B 1 229 ? -5.727  47.684  -51.564 1.00 51.05  ? 229 LEU B C   1 
ATOM   5686  O O   . LEU B 1 229 ? -4.983  47.914  -52.519 1.00 47.89  ? 229 LEU B O   1 
ATOM   5687  C CB  . LEU B 1 229 ? -4.607  45.758  -50.388 1.00 55.07  ? 229 LEU B CB  1 
ATOM   5688  C CG  . LEU B 1 229 ? -4.038  46.612  -49.247 1.00 55.77  ? 229 LEU B CG  1 
ATOM   5689  C CD1 . LEU B 1 229 ? -5.022  46.736  -48.073 1.00 57.63  ? 229 LEU B CD1 1 
ATOM   5690  C CD2 . LEU B 1 229 ? -2.718  46.051  -48.771 1.00 53.09  ? 229 LEU B CD2 1 
ATOM   5691  N N   . SER B 1 230 ? -6.424  48.635  -50.945 1.00 51.77  ? 230 SER B N   1 
ATOM   5692  C CA  . SER B 1 230 ? -6.348  50.044  -51.300 1.00 57.27  ? 230 SER B CA  1 
ATOM   5693  C C   . SER B 1 230 ? -5.856  50.827  -50.084 1.00 55.42  ? 230 SER B C   1 
ATOM   5694  O O   . SER B 1 230 ? -6.527  50.789  -49.048 1.00 55.07  ? 230 SER B O   1 
ATOM   5695  C CB  . SER B 1 230 ? -7.701  50.576  -51.743 1.00 56.61  ? 230 SER B CB  1 
ATOM   5696  O OG  . SER B 1 230 ? -8.076  50.094  -53.024 1.00 53.07  ? 230 SER B OG  1 
ATOM   5697  N N   . LEU B 1 231 ? -4.700  51.499  -50.233 1.00 50.65  ? 231 LEU B N   1 
ATOM   5698  C CA  . LEU B 1 231 ? -4.165  52.465  -49.280 1.00 53.35  ? 231 LEU B CA  1 
ATOM   5699  C C   . LEU B 1 231 ? -4.833  53.825  -49.513 1.00 56.55  ? 231 LEU B C   1 
ATOM   5700  O O   . LEU B 1 231 ? -4.716  54.393  -50.602 1.00 54.27  ? 231 LEU B O   1 
ATOM   5701  C CB  . LEU B 1 231 ? -2.655  52.582  -49.477 1.00 54.48  ? 231 LEU B CB  1 
ATOM   5702  C CG  . LEU B 1 231 ? -1.797  51.479  -48.860 1.00 59.63  ? 231 LEU B CG  1 
ATOM   5703  C CD1 . LEU B 1 231 ? -2.353  50.090  -49.089 1.00 67.77  ? 231 LEU B CD1 1 
ATOM   5704  C CD2 . LEU B 1 231 ? -0.386  51.599  -49.405 1.00 59.04  ? 231 LEU B CD2 1 
ATOM   5705  N N   . VAL B 1 232 ? -5.534  54.333  -48.488 1.00 52.39  ? 232 VAL B N   1 
ATOM   5706  C CA  . VAL B 1 232 ? -6.224  55.614  -48.552 1.00 52.86  ? 232 VAL B CA  1 
ATOM   5707  C C   . VAL B 1 232 ? -5.526  56.615  -47.617 1.00 51.10  ? 232 VAL B C   1 
ATOM   5708  O O   . VAL B 1 232 ? -5.772  56.644  -46.412 1.00 49.63  ? 232 VAL B O   1 
ATOM   5709  C CB  . VAL B 1 232 ? -7.711  55.379  -48.213 1.00 48.56  ? 232 VAL B CB  1 
ATOM   5710  C CG1 . VAL B 1 232 ? -8.526  56.660  -48.209 1.00 45.30  ? 232 VAL B CG1 1 
ATOM   5711  C CG2 . VAL B 1 232 ? -8.338  54.382  -49.174 1.00 51.99  ? 232 VAL B CG2 1 
ATOM   5712  N N   . CYS B 1 233 ? -4.639  57.444  -48.181 1.00 49.44  ? 233 CYS B N   1 
ATOM   5713  C CA  . CYS B 1 233 ? -3.776  58.303  -47.387 1.00 52.04  ? 233 CYS B CA  1 
ATOM   5714  C C   . CYS B 1 233 ? -4.238  59.751  -47.441 1.00 55.42  ? 233 CYS B C   1 
ATOM   5715  O O   . CYS B 1 233 ? -4.871  60.199  -48.401 1.00 47.86  ? 233 CYS B O   1 
ATOM   5716  C CB  . CYS B 1 233 ? -2.334  58.289  -47.870 1.00 49.15  ? 233 CYS B CB  1 
ATOM   5717  S SG  . CYS B 1 233 ? -1.648  56.620  -47.862 1.00 54.81  ? 233 CYS B SG  1 
ATOM   5718  N N   . ARG B 1 234 ? -3.824  60.468  -46.393 1.00 55.76  ? 234 ARG B N   1 
ATOM   5719  C CA  . ARG B 1 234 ? -4.004  61.904  -46.284 1.00 52.98  ? 234 ARG B CA  1 
ATOM   5720  C C   . ARG B 1 234 ? -3.247  62.621  -47.410 1.00 56.09  ? 234 ARG B C   1 
ATOM   5721  O O   . ARG B 1 234 ? -2.258  62.105  -47.954 1.00 54.19  ? 234 ARG B O   1 
ATOM   5722  C CB  . ARG B 1 234 ? -3.526  62.322  -44.884 1.00 47.61  ? 234 ARG B CB  1 
ATOM   5723  C CG  . ARG B 1 234 ? -2.017  62.347  -44.679 1.00 45.54  ? 234 ARG B CG  1 
ATOM   5724  C CD  . ARG B 1 234 ? -1.650  62.852  -43.293 1.00 46.72  ? 234 ARG B CD  1 
ATOM   5725  N NE  . ARG B 1 234 ? -0.219  62.717  -42.997 1.00 42.85  ? 234 ARG B NE  1 
ATOM   5726  C CZ  . ARG B 1 234 ? 0.769   63.411  -43.575 1.00 47.09  ? 234 ARG B CZ  1 
ATOM   5727  N NH1 . ARG B 1 234 ? 0.545   64.347  -44.498 1.00 52.52  ? 234 ARG B NH1 1 
ATOM   5728  N NH2 . ARG B 1 234 ? 2.016   63.181  -43.207 1.00 45.28  ? 234 ARG B NH2 1 
ATOM   5729  N N   . GLN B 1 235 ? -3.693  63.855  -47.696 1.00 50.90  ? 235 GLN B N   1 
ATOM   5730  C CA  . GLN B 1 235 ? -3.039  64.724  -48.660 1.00 46.68  ? 235 GLN B CA  1 
ATOM   5731  C C   . GLN B 1 235 ? -1.560  64.876  -48.308 1.00 44.75  ? 235 GLN B C   1 
ATOM   5732  O O   . GLN B 1 235 ? -1.183  64.944  -47.130 1.00 47.89  ? 235 GLN B O   1 
ATOM   5733  C CB  . GLN B 1 235 ? -3.699  66.113  -48.681 1.00 47.13  ? 235 GLN B CB  1 
ATOM   5734  C CG  . GLN B 1 235 ? -3.103  67.036  -49.741 1.00 45.24  ? 235 GLN B CG  1 
ATOM   5735  C CD  . GLN B 1 235 ? -3.232  66.436  -51.125 1.00 50.63  ? 235 GLN B CD  1 
ATOM   5736  O OE1 . GLN B 1 235 ? -2.379  65.677  -51.611 1.00 50.44  ? 235 GLN B OE1 1 
ATOM   5737  N NE2 . GLN B 1 235 ? -4.379  66.687  -51.726 1.00 49.46  ? 235 GLN B NE2 1 
ATOM   5738  N N   . SER B 1 236 ? -0.719  64.972  -49.339 1.00 45.80  ? 236 SER B N   1 
ATOM   5739  C CA  . SER B 1 236 ? 0.682   65.305  -49.115 1.00 45.50  ? 236 SER B CA  1 
ATOM   5740  C C   . SER B 1 236 ? 0.837   66.791  -48.774 1.00 53.94  ? 236 SER B C   1 
ATOM   5741  O O   . SER B 1 236 ? 0.169   67.645  -49.353 1.00 47.74  ? 236 SER B O   1 
ATOM   5742  C CB  . SER B 1 236 ? 1.529   64.936  -50.283 1.00 42.74  ? 236 SER B CB  1 
ATOM   5743  O OG  . SER B 1 236 ? 2.898   65.134  -49.959 1.00 43.38  ? 236 SER B OG  1 
ATOM   5744  N N   . ASN B 1 237 ? 1.726   67.077  -47.812 1.00 57.78  ? 237 ASN B N   1 
ATOM   5745  C CA  . ASN B 1 237 ? 2.122   68.435  -47.482 1.00 50.87  ? 237 ASN B CA  1 
ATOM   5746  C C   . ASN B 1 237 ? 3.543   68.678  -47.992 1.00 51.64  ? 237 ASN B C   1 
ATOM   5747  O O   . ASN B 1 237 ? 4.171   69.689  -47.657 1.00 50.56  ? 237 ASN B O   1 
ATOM   5748  C CB  . ASN B 1 237 ? 1.978   68.701  -45.987 1.00 47.85  ? 237 ASN B CB  1 
ATOM   5749  C CG  . ASN B 1 237 ? 0.558   68.527  -45.488 1.00 47.75  ? 237 ASN B CG  1 
ATOM   5750  O OD1 . ASN B 1 237 ? -0.370  69.133  -46.027 1.00 49.22  ? 237 ASN B OD1 1 
ATOM   5751  N ND2 . ASN B 1 237 ? 0.353   67.711  -44.464 1.00 45.51  ? 237 ASN B ND2 1 
ATOM   5752  N N   . ALA B 1 238 ? 4.050   67.747  -48.808 1.00 49.78  ? 238 ALA B N   1 
ATOM   5753  C CA  . ALA B 1 238 ? 5.354   67.905  -49.444 1.00 56.79  ? 238 ALA B CA  1 
ATOM   5754  C C   . ALA B 1 238 ? 5.355   69.099  -50.414 1.00 52.40  ? 238 ALA B C   1 
ATOM   5755  O O   . ALA B 1 238 ? 4.340   69.394  -51.060 1.00 45.97  ? 238 ALA B O   1 
ATOM   5756  C CB  . ALA B 1 238 ? 5.718   66.617  -50.153 1.00 52.88  ? 238 ALA B CB  1 
ATOM   5757  N N   . THR B 1 239 ? 6.495   69.799  -50.497 1.00 50.25  ? 239 THR B N   1 
ATOM   5758  C CA  . THR B 1 239 ? 6.621   70.991  -51.342 1.00 54.87  ? 239 THR B CA  1 
ATOM   5759  C C   . THR B 1 239 ? 7.926   70.891  -52.118 1.00 53.28  ? 239 THR B C   1 
ATOM   5760  O O   . THR B 1 239 ? 8.846   71.675  -51.896 1.00 50.59  ? 239 THR B O   1 
ATOM   5761  C CB  . THR B 1 239 ? 6.544   72.307  -50.555 1.00 47.63  ? 239 THR B CB  1 
ATOM   5762  O OG1 . THR B 1 239 ? 7.578   72.407  -49.559 1.00 36.56  ? 239 THR B OG1 1 
ATOM   5763  C CG2 . THR B 1 239 ? 5.160   72.485  -49.947 1.00 45.40  ? 239 THR B CG2 1 
ATOM   5764  N N   . PRO B 1 240 ? 8.018   69.926  -53.061 1.00 61.07  ? 240 PRO B N   1 
ATOM   5765  C CA  . PRO B 1 240 ? 9.264   69.688  -53.801 1.00 63.56  ? 240 PRO B CA  1 
ATOM   5766  C C   . PRO B 1 240 ? 9.638   70.786  -54.801 1.00 63.53  ? 240 PRO B C   1 
ATOM   5767  O O   . PRO B 1 240 ? 10.772  70.789  -55.273 1.00 67.22  ? 240 PRO B O   1 
ATOM   5768  C CB  . PRO B 1 240 ? 8.979   68.339  -54.497 1.00 61.12  ? 240 PRO B CB  1 
ATOM   5769  C CG  . PRO B 1 240 ? 7.481   68.388  -54.748 1.00 66.75  ? 240 PRO B CG  1 
ATOM   5770  C CD  . PRO B 1 240 ? 6.902   69.067  -53.506 1.00 62.35  ? 240 PRO B CD  1 
ATOM   5771  N N   . ASP B 1 241 ? 8.685   71.688  -55.128 1.00 68.43  ? 241 ASP B N   1 
ATOM   5772  C CA  . ASP B 1 241 ? 8.918   72.835  -56.011 1.00 75.79  ? 241 ASP B CA  1 
ATOM   5773  C C   . ASP B 1 241 ? 9.299   74.105  -55.235 1.00 78.00  ? 241 ASP B C   1 
ATOM   5774  O O   . ASP B 1 241 ? 9.846   75.043  -55.814 1.00 68.40  ? 241 ASP B O   1 
ATOM   5775  C CB  . ASP B 1 241 ? 7.691   73.191  -56.845 1.00 75.77  ? 241 ASP B CB  1 
ATOM   5776  C CG  . ASP B 1 241 ? 7.350   72.265  -58.002 1.00 79.43  ? 241 ASP B CG  1 
ATOM   5777  O OD1 . ASP B 1 241 ? 8.232   71.460  -58.386 1.00 69.83  ? 241 ASP B OD1 1 
ATOM   5778  O OD2 . ASP B 1 241 ? 6.199   72.365  -58.505 1.00 83.65  ? 241 ASP B OD2 1 
ATOM   5779  N N   . ALA B 1 242 ? 8.985   74.164  -53.934 1.00 72.29  ? 242 ALA B N   1 
ATOM   5780  C CA  . ALA B 1 242 ? 9.329   75.323  -53.125 1.00 68.43  ? 242 ALA B CA  1 
ATOM   5781  C C   . ALA B 1 242 ? 10.852  75.519  -53.043 1.00 70.84  ? 242 ALA B C   1 
ATOM   5782  O O   . ALA B 1 242 ? 11.639  74.633  -53.398 1.00 62.00  ? 242 ALA B O   1 
ATOM   5783  C CB  . ALA B 1 242 ? 8.701   75.183  -51.750 1.00 65.05  ? 242 ALA B CB  1 
ATOM   5784  N N   . ASP B 1 243 ? 11.254  76.719  -52.588 1.00 64.04  ? 243 ASP B N   1 
ATOM   5785  C CA  . ASP B 1 243 ? 12.650  77.045  -52.347 1.00 64.40  ? 243 ASP B CA  1 
ATOM   5786  C C   . ASP B 1 243 ? 13.029  76.487  -50.973 1.00 65.11  ? 243 ASP B C   1 
ATOM   5787  O O   . ASP B 1 243 ? 12.317  76.716  -49.987 1.00 54.22  ? 243 ASP B O   1 
ATOM   5788  C CB  . ASP B 1 243 ? 12.915  78.542  -52.507 1.00 61.63  ? 243 ASP B CB  1 
ATOM   5789  C CG  . ASP B 1 243 ? 14.373  78.956  -52.666 1.00 65.34  ? 243 ASP B CG  1 
ATOM   5790  O OD1 . ASP B 1 243 ? 15.231  78.446  -51.886 1.00 57.73  ? 243 ASP B OD1 1 
ATOM   5791  O OD2 . ASP B 1 243 ? 14.646  79.792  -53.564 1.00 72.39  ? 243 ASP B OD2 1 
ATOM   5792  N N   . PRO B 1 244 ? 14.145  75.717  -50.884 1.00 64.89  ? 244 PRO B N   1 
ATOM   5793  C CA  . PRO B 1 244 ? 14.687  75.255  -49.601 1.00 64.47  ? 244 PRO B CA  1 
ATOM   5794  C C   . PRO B 1 244 ? 14.869  76.307  -48.507 1.00 59.72  ? 244 PRO B C   1 
ATOM   5795  O O   . PRO B 1 244 ? 14.815  75.966  -47.328 1.00 62.71  ? 244 PRO B O   1 
ATOM   5796  C CB  . PRO B 1 244 ? 16.055  74.639  -49.990 1.00 64.07  ? 244 PRO B CB  1 
ATOM   5797  C CG  . PRO B 1 244 ? 15.876  74.209  -51.414 1.00 65.16  ? 244 PRO B CG  1 
ATOM   5798  C CD  . PRO B 1 244 ? 14.912  75.212  -52.035 1.00 64.70  ? 244 PRO B CD  1 
ATOM   5799  N N   . TYR B 1 245 ? 15.154  77.562  -48.883 1.00 60.76  ? 245 TYR B N   1 
ATOM   5800  C CA  . TYR B 1 245 ? 15.322  78.620  -47.895 1.00 56.86  ? 245 TYR B CA  1 
ATOM   5801  C C   . TYR B 1 245 ? 13.956  78.919  -47.274 1.00 53.25  ? 245 TYR B C   1 
ATOM   5802  O O   . TYR B 1 245 ? 13.849  79.091  -46.060 1.00 51.28  ? 245 TYR B O   1 
ATOM   5803  C CB  . TYR B 1 245 ? 16.003  79.890  -48.426 1.00 56.99  ? 245 TYR B CB  1 
ATOM   5804  C CG  . TYR B 1 245 ? 16.144  80.955  -47.347 1.00 54.68  ? 245 TYR B CG  1 
ATOM   5805  C CD1 . TYR B 1 245 ? 17.255  81.002  -46.512 1.00 52.97  ? 245 TYR B CD1 1 
ATOM   5806  C CD2 . TYR B 1 245 ? 15.127  81.881  -47.128 1.00 54.77  ? 245 TYR B CD2 1 
ATOM   5807  C CE1 . TYR B 1 245 ? 17.360  81.955  -45.507 1.00 56.54  ? 245 TYR B CE1 1 
ATOM   5808  C CE2 . TYR B 1 245 ? 15.222  82.837  -46.128 1.00 59.02  ? 245 TYR B CE2 1 
ATOM   5809  C CZ  . TYR B 1 245 ? 16.341  82.879  -45.309 1.00 59.22  ? 245 TYR B CZ  1 
ATOM   5810  O OH  . TYR B 1 245 ? 16.400  83.841  -44.324 1.00 52.63  ? 245 TYR B OH  1 
ATOM   5811  N N   . ASP B 1 246 ? 12.911  78.915  -48.102 1.00 54.91  ? 246 ASP B N   1 
ATOM   5812  C CA  . ASP B 1 246 ? 11.556  79.207  -47.652 1.00 58.59  ? 246 ASP B CA  1 
ATOM   5813  C C   . ASP B 1 246 ? 10.979  78.060  -46.822 1.00 65.06  ? 246 ASP B C   1 
ATOM   5814  O O   . ASP B 1 246 ? 10.372  78.284  -45.771 1.00 60.46  ? 246 ASP B O   1 
ATOM   5815  C CB  . ASP B 1 246 ? 10.638  79.489  -48.835 1.00 57.45  ? 246 ASP B CB  1 
ATOM   5816  C CG  . ASP B 1 246 ? 11.030  80.688  -49.688 1.00 54.48  ? 246 ASP B CG  1 
ATOM   5817  O OD1 . ASP B 1 246 ? 11.775  81.537  -49.175 1.00 58.45  ? 246 ASP B OD1 1 
ATOM   5818  O OD2 . ASP B 1 246 ? 10.639  80.727  -50.870 1.00 59.27  ? 246 ASP B OD2 1 
ATOM   5819  N N   . HIS B 1 247 ? 11.115  76.833  -47.339 1.00 70.28  ? 247 HIS B N   1 
ATOM   5820  C CA  . HIS B 1 247 ? 10.538  75.660  -46.695 1.00 70.63  ? 247 HIS B CA  1 
ATOM   5821  C C   . HIS B 1 247 ? 11.632  74.588  -46.615 1.00 59.60  ? 247 HIS B C   1 
ATOM   5822  O O   . HIS B 1 247 ? 11.766  73.783  -47.529 1.00 52.23  ? 247 HIS B O   1 
ATOM   5823  C CB  . HIS B 1 247 ? 9.219   75.299  -47.404 1.00 69.56  ? 247 HIS B CB  1 
ATOM   5824  C CG  . HIS B 1 247 ? 8.073   76.241  -47.128 1.00 76.33  ? 247 HIS B CG  1 
ATOM   5825  N ND1 . HIS B 1 247 ? 7.659   76.596  -45.857 1.00 83.48  ? 247 HIS B ND1 1 
ATOM   5826  C CD2 . HIS B 1 247 ? 7.251   76.891  -47.965 1.00 71.21  ? 247 HIS B CD2 1 
ATOM   5827  C CE1 . HIS B 1 247 ? 6.635   77.435  -45.933 1.00 78.98  ? 247 HIS B CE1 1 
ATOM   5828  N NE2 . HIS B 1 247 ? 6.378   77.634  -47.205 1.00 77.04  ? 247 HIS B NE2 1 
ATOM   5829  N N   . PRO B 1 248 ? 12.485  74.573  -45.557 1.00 54.48  ? 248 PRO B N   1 
ATOM   5830  C CA  . PRO B 1 248 ? 13.600  73.617  -45.486 1.00 54.73  ? 248 PRO B CA  1 
ATOM   5831  C C   . PRO B 1 248 ? 13.240  72.153  -45.202 1.00 57.31  ? 248 PRO B C   1 
ATOM   5832  O O   . PRO B 1 248 ? 14.108  71.278  -45.293 1.00 49.57  ? 248 PRO B O   1 
ATOM   5833  C CB  . PRO B 1 248 ? 14.524  74.204  -44.369 1.00 51.25  ? 248 PRO B CB  1 
ATOM   5834  C CG  . PRO B 1 248 ? 13.599  75.050  -43.511 1.00 54.74  ? 248 PRO B CG  1 
ATOM   5835  C CD  . PRO B 1 248 ? 12.443  75.494  -44.402 1.00 52.64  ? 248 PRO B CD  1 
ATOM   5836  N N   . LEU B 1 249 ? 11.983  71.885  -44.807 1.00 46.45  ? 249 LEU B N   1 
ATOM   5837  C CA  . LEU B 1 249 ? 11.644  70.542  -44.376 1.00 49.60  ? 249 LEU B CA  1 
ATOM   5838  C C   . LEU B 1 249 ? 10.611  69.950  -45.329 1.00 51.62  ? 249 LEU B C   1 
ATOM   5839  O O   . LEU B 1 249 ? 10.791  68.822  -45.791 1.00 50.34  ? 249 LEU B O   1 
ATOM   5840  C CB  . LEU B 1 249 ? 11.186  70.512  -42.916 1.00 47.70  ? 249 LEU B CB  1 
ATOM   5841  C CG  . LEU B 1 249 ? 12.186  71.051  -41.880 1.00 49.90  ? 249 LEU B CG  1 
ATOM   5842  C CD1 . LEU B 1 249 ? 11.621  71.037  -40.466 1.00 51.84  ? 249 LEU B CD1 1 
ATOM   5843  C CD2 . LEU B 1 249 ? 13.540  70.320  -41.891 1.00 50.51  ? 249 LEU B CD2 1 
ATOM   5844  N N   . SER B 1 250 ? 9.562   70.727  -45.640 1.00 52.04  ? 250 SER B N   1 
ATOM   5845  C CA  . SER B 1 250 ? 8.517   70.277  -46.551 1.00 57.97  ? 250 SER B CA  1 
ATOM   5846  C C   . SER B 1 250 ? 9.090   69.954  -47.941 1.00 62.47  ? 250 SER B C   1 
ATOM   5847  O O   . SER B 1 250 ? 8.529   69.111  -48.646 1.00 59.12  ? 250 SER B O   1 
ATOM   5848  C CB  . SER B 1 250 ? 7.333   71.251  -46.610 1.00 58.59  ? 250 SER B CB  1 
ATOM   5849  O OG  . SER B 1 250 ? 7.653   72.528  -47.158 1.00 49.56  ? 250 SER B OG  1 
ATOM   5850  N N   . THR B 1 251 ? 10.224  70.578  -48.317 1.00 54.92  ? 251 THR B N   1 
ATOM   5851  C CA  . THR B 1 251 ? 10.889  70.270  -49.579 1.00 63.59  ? 251 THR B CA  1 
ATOM   5852  C C   . THR B 1 251 ? 11.487  68.861  -49.551 1.00 64.38  ? 251 THR B C   1 
ATOM   5853  O O   . THR B 1 251 ? 11.628  68.251  -50.612 1.00 48.26  ? 251 THR B O   1 
ATOM   5854  C CB  . THR B 1 251 ? 11.964  71.307  -49.913 1.00 55.72  ? 251 THR B CB  1 
ATOM   5855  O OG1 . THR B 1 251 ? 12.721  71.433  -48.714 1.00 62.16  ? 251 THR B OG1 1 
ATOM   5856  C CG2 . THR B 1 251 ? 11.366  72.645  -50.292 1.00 52.91  ? 251 THR B CG2 1 
ATOM   5857  N N   . ILE B 1 252 ? 11.831  68.349  -48.352 1.00 62.82  ? 252 ILE B N   1 
ATOM   5858  C CA  . ILE B 1 252 ? 12.430  67.025  -48.234 1.00 62.38  ? 252 ILE B CA  1 
ATOM   5859  C C   . ILE B 1 252 ? 11.371  65.979  -48.580 1.00 58.96  ? 252 ILE B C   1 
ATOM   5860  O O   . ILE B 1 252 ? 11.604  65.109  -49.412 1.00 55.50  ? 252 ILE B O   1 
ATOM   5861  C CB  . ILE B 1 252 ? 13.053  66.796  -46.844 1.00 66.95  ? 252 ILE B CB  1 
ATOM   5862  C CG1 . ILE B 1 252 ? 14.100  67.873  -46.488 1.00 63.38  ? 252 ILE B CG1 1 
ATOM   5863  C CG2 . ILE B 1 252 ? 13.648  65.390  -46.750 1.00 66.07  ? 252 ILE B CG2 1 
ATOM   5864  C CD1 . ILE B 1 252 ? 14.576  67.808  -45.047 1.00 60.42  ? 252 ILE B CD1 1 
ATOM   5865  N N   . GLY B 1 253 ? 10.187  66.096  -47.968 1.00 56.49  ? 253 GLY B N   1 
ATOM   5866  C CA  . GLY B 1 253 ? 9.069   65.237  -48.311 1.00 55.75  ? 253 GLY B CA  1 
ATOM   5867  C C   . GLY B 1 253 ? 8.133   65.102  -47.119 1.00 55.43  ? 253 GLY B C   1 
ATOM   5868  O O   . GLY B 1 253 ? 8.292   65.830  -46.143 1.00 51.73  ? 253 GLY B O   1 
ATOM   5869  N N   . ASP B 1 254 ? 7.183   64.162  -47.209 1.00 48.23  ? 254 ASP B N   1 
ATOM   5870  C CA  . ASP B 1 254 ? 6.164   64.019  -46.185 1.00 50.58  ? 254 ASP B CA  1 
ATOM   5871  C C   . ASP B 1 254 ? 5.839   62.536  -45.941 1.00 48.03  ? 254 ASP B C   1 
ATOM   5872  O O   . ASP B 1 254 ? 5.352   61.825  -46.832 1.00 47.84  ? 254 ASP B O   1 
ATOM   5873  C CB  . ASP B 1 254 ? 4.977   64.907  -46.521 1.00 49.09  ? 254 ASP B CB  1 
ATOM   5874  C CG  . ASP B 1 254 ? 3.887   64.930  -45.463 1.00 55.55  ? 254 ASP B CG  1 
ATOM   5875  O OD1 . ASP B 1 254 ? 4.218   64.522  -44.315 1.00 59.38  ? 254 ASP B OD1 1 
ATOM   5876  O OD2 . ASP B 1 254 ? 2.715   65.306  -45.811 1.00 50.12  ? 254 ASP B OD2 1 
ATOM   5877  N N   . GLU B 1 255 ? 6.141   62.082  -44.719 1.00 41.26  ? 255 GLU B N   1 
ATOM   5878  C CA  . GLU B 1 255 ? 5.803   60.754  -44.232 1.00 44.56  ? 255 GLU B CA  1 
ATOM   5879  C C   . GLU B 1 255 ? 4.288   60.596  -44.080 1.00 50.35  ? 255 GLU B C   1 
ATOM   5880  O O   . GLU B 1 255 ? 3.735   60.797  -43.000 1.00 54.30  ? 255 GLU B O   1 
ATOM   5881  C CB  . GLU B 1 255 ? 6.513   60.537  -42.899 1.00 48.42  ? 255 GLU B CB  1 
ATOM   5882  C CG  . GLU B 1 255 ? 6.381   59.137  -42.289 1.00 50.33  ? 255 GLU B CG  1 
ATOM   5883  C CD  . GLU B 1 255 ? 7.288   58.941  -41.072 1.00 52.81  ? 255 GLU B CD  1 
ATOM   5884  O OE1 . GLU B 1 255 ? 7.020   59.550  -39.989 1.00 53.67  ? 255 GLU B OE1 1 
ATOM   5885  O OE2 . GLU B 1 255 ? 8.306   58.217  -41.216 1.00 47.00  ? 255 GLU B OE2 1 
ATOM   5886  N N   . LEU B 1 256 ? 3.629   60.114  -45.142 1.00 53.24  ? 256 LEU B N   1 
ATOM   5887  C CA  . LEU B 1 256 ? 2.176   60.052  -45.179 1.00 51.12  ? 256 LEU B CA  1 
ATOM   5888  C C   . LEU B 1 256 ? 1.638   59.012  -44.203 1.00 55.98  ? 256 LEU B C   1 
ATOM   5889  O O   . LEU B 1 256 ? 2.262   57.981  -43.951 1.00 58.64  ? 256 LEU B O   1 
ATOM   5890  C CB  . LEU B 1 256 ? 1.697   59.743  -46.597 1.00 52.11  ? 256 LEU B CB  1 
ATOM   5891  C CG  . LEU B 1 256 ? 2.120   60.740  -47.684 1.00 58.33  ? 256 LEU B CG  1 
ATOM   5892  C CD1 . LEU B 1 256 ? 1.472   60.382  -49.026 1.00 57.43  ? 256 LEU B CD1 1 
ATOM   5893  C CD2 . LEU B 1 256 ? 1.813   62.192  -47.295 1.00 52.76  ? 256 LEU B CD2 1 
ATOM   5894  N N   . ASP B 1 257 ? 0.429   59.301  -43.714 1.00 61.03  ? 257 ASP B N   1 
ATOM   5895  C CA  . ASP B 1 257 ? -0.364  58.392  -42.900 1.00 53.12  ? 257 ASP B CA  1 
ATOM   5896  C C   . ASP B 1 257 ? -1.621  58.039  -43.698 1.00 54.35  ? 257 ASP B C   1 
ATOM   5897  O O   . ASP B 1 257 ? -2.024  58.790  -44.598 1.00 42.09  ? 257 ASP B O   1 
ATOM   5898  C CB  . ASP B 1 257 ? -0.705  59.020  -41.552 1.00 52.75  ? 257 ASP B CB  1 
ATOM   5899  C CG  . ASP B 1 257 ? 0.443   59.745  -40.861 1.00 57.19  ? 257 ASP B CG  1 
ATOM   5900  O OD1 . ASP B 1 257 ? 1.366   59.054  -40.364 1.00 54.15  ? 257 ASP B OD1 1 
ATOM   5901  O OD2 . ASP B 1 257 ? 0.424   61.001  -40.876 1.00 55.48  ? 257 ASP B OD2 1 
ATOM   5902  N N   . GLY B 1 258 ? -2.241  56.890  -43.369 1.00 55.30  ? 258 GLY B N   1 
ATOM   5903  C CA  . GLY B 1 258 ? -3.480  56.532  -44.033 1.00 55.88  ? 258 GLY B CA  1 
ATOM   5904  C C   . GLY B 1 258 ? -4.253  55.393  -43.378 1.00 54.21  ? 258 GLY B C   1 
ATOM   5905  O O   . GLY B 1 258 ? -3.786  54.743  -42.436 1.00 44.25  ? 258 GLY B O   1 
ATOM   5906  N N   . MET B 1 259 ? -5.464  55.214  -43.934 1.00 53.95  ? 259 MET B N   1 
ATOM   5907  C CA  . MET B 1 259 ? -6.328  54.067  -43.723 1.00 53.36  ? 259 MET B CA  1 
ATOM   5908  C C   . MET B 1 259 ? -6.062  53.052  -44.833 1.00 53.60  ? 259 MET B C   1 
ATOM   5909  O O   . MET B 1 259 ? -5.342  53.361  -45.782 1.00 50.70  ? 259 MET B O   1 
ATOM   5910  C CB  . MET B 1 259 ? -7.796  54.500  -43.762 1.00 57.68  ? 259 MET B CB  1 
ATOM   5911  C CG  . MET B 1 259 ? -8.114  55.727  -42.906 1.00 56.31  ? 259 MET B CG  1 
ATOM   5912  S SD  . MET B 1 259 ? -9.831  56.244  -43.092 1.00 57.72  ? 259 MET B SD  1 
ATOM   5913  C CE  . MET B 1 259 ? -10.680 54.854  -42.340 1.00 59.75  ? 259 MET B CE  1 
ATOM   5914  N N   . ALA B 1 260 ? -6.626  51.841  -44.696 1.00 51.92  ? 260 ALA B N   1 
ATOM   5915  C CA  . ALA B 1 260 ? -6.490  50.814  -45.718 1.00 51.58  ? 260 ALA B CA  1 
ATOM   5916  C C   . ALA B 1 260 ? -7.783  50.011  -45.802 1.00 54.00  ? 260 ALA B C   1 
ATOM   5917  O O   . ALA B 1 260 ? -8.311  49.602  -44.771 1.00 54.23  ? 260 ALA B O   1 
ATOM   5918  C CB  . ALA B 1 260 ? -5.293  49.941  -45.422 1.00 51.45  ? 260 ALA B CB  1 
ATOM   5919  N N   . TYR B 1 261 ? -8.305  49.857  -47.031 1.00 54.25  ? 261 TYR B N   1 
ATOM   5920  C CA  . TYR B 1 261 ? -9.501  49.064  -47.296 1.00 56.26  ? 261 TYR B CA  1 
ATOM   5921  C C   . TYR B 1 261 ? -9.073  47.733  -47.921 1.00 55.85  ? 261 TYR B C   1 
ATOM   5922  O O   . TYR B 1 261 ? -8.331  47.718  -48.921 1.00 44.42  ? 261 TYR B O   1 
ATOM   5923  C CB  . TYR B 1 261 ? -10.564 49.675  -48.221 1.00 55.98  ? 261 TYR B CB  1 
ATOM   5924  C CG  . TYR B 1 261 ? -11.836 48.831  -48.247 1.00 62.31  ? 261 TYR B CG  1 
ATOM   5925  C CD1 . TYR B 1 261 ? -12.704 48.816  -47.154 1.00 58.12  ? 261 TYR B CD1 1 
ATOM   5926  C CD2 . TYR B 1 261 ? -12.154 48.015  -49.335 1.00 61.28  ? 261 TYR B CD2 1 
ATOM   5927  C CE1 . TYR B 1 261 ? -13.844 48.029  -47.143 1.00 55.39  ? 261 TYR B CE1 1 
ATOM   5928  C CE2 . TYR B 1 261 ? -13.301 47.233  -49.338 1.00 56.63  ? 261 TYR B CE2 1 
ATOM   5929  C CZ  . TYR B 1 261 ? -14.140 47.228  -48.231 1.00 57.79  ? 261 TYR B CZ  1 
ATOM   5930  O OH  . TYR B 1 261 ? -15.275 46.456  -48.200 1.00 55.54  ? 261 TYR B OH  1 
ATOM   5931  N N   . PHE B 1 262 ? -9.547  46.636  -47.295 1.00 50.67  ? 262 PHE B N   1 
ATOM   5932  C CA  . PHE B 1 262 ? -9.319  45.275  -47.768 1.00 53.88  ? 262 PHE B CA  1 
ATOM   5933  C C   . PHE B 1 262 ? -10.602 44.787  -48.446 1.00 52.32  ? 262 PHE B C   1 
ATOM   5934  O O   . PHE B 1 262 ? -11.597 44.534  -47.766 1.00 53.23  ? 262 PHE B O   1 
ATOM   5935  C CB  . PHE B 1 262 ? -8.913  44.353  -46.610 1.00 51.03  ? 262 PHE B CB  1 
ATOM   5936  C CG  . PHE B 1 262 ? -7.598  44.714  -45.929 1.00 53.16  ? 262 PHE B CG  1 
ATOM   5937  C CD1 . PHE B 1 262 ? -7.477  45.884  -45.180 1.00 47.39  ? 262 PHE B CD1 1 
ATOM   5938  C CD2 . PHE B 1 262 ? -6.493  43.874  -46.024 1.00 51.32  ? 262 PHE B CD2 1 
ATOM   5939  C CE1 . PHE B 1 262 ? -6.279  46.215  -44.578 1.00 46.44  ? 262 PHE B CE1 1 
ATOM   5940  C CE2 . PHE B 1 262 ? -5.300  44.214  -45.420 1.00 48.84  ? 262 PHE B CE2 1 
ATOM   5941  C CZ  . PHE B 1 262 ? -5.200  45.382  -44.697 1.00 51.25  ? 262 PHE B CZ  1 
ATOM   5942  N N   . ASP B 1 263 ? -10.575 44.662  -49.780 1.00 52.07  ? 263 ASP B N   1 
ATOM   5943  C CA  . ASP B 1 263 ? -11.725 44.181  -50.532 1.00 60.12  ? 263 ASP B CA  1 
ATOM   5944  C C   . ASP B 1 263 ? -11.581 42.695  -50.892 1.00 57.71  ? 263 ASP B C   1 
ATOM   5945  O O   . ASP B 1 263 ? -11.098 42.370  -51.977 1.00 51.36  ? 263 ASP B O   1 
ATOM   5946  C CB  . ASP B 1 263 ? -11.934 44.987  -51.802 1.00 58.44  ? 263 ASP B CB  1 
ATOM   5947  C CG  . ASP B 1 263 ? -13.152 44.567  -52.611 1.00 56.79  ? 263 ASP B CG  1 
ATOM   5948  O OD1 . ASP B 1 263 ? -14.184 44.201  -51.991 1.00 62.25  ? 263 ASP B OD1 1 
ATOM   5949  O OD2 . ASP B 1 263 ? -13.068 44.632  -53.843 1.00 55.24  ? 263 ASP B OD2 1 
ATOM   5950  N N   . ASP B 1 264 ? -12.079 41.815  -50.003 1.00 55.87  ? 264 ASP B N   1 
ATOM   5951  C CA  . ASP B 1 264 ? -11.924 40.363  -50.103 1.00 54.56  ? 264 ASP B CA  1 
ATOM   5952  C C   . ASP B 1 264 ? -10.461 40.029  -50.388 1.00 51.84  ? 264 ASP B C   1 
ATOM   5953  O O   . ASP B 1 264 ? -10.147 39.371  -51.362 1.00 49.10  ? 264 ASP B O   1 
ATOM   5954  C CB  . ASP B 1 264 ? -12.921 39.742  -51.076 1.00 48.44  ? 264 ASP B CB  1 
ATOM   5955  C CG  . ASP B 1 264 ? -14.392 39.900  -50.690 1.00 51.19  ? 264 ASP B CG  1 
ATOM   5956  O OD1 . ASP B 1 264 ? -14.687 40.167  -49.493 1.00 52.08  ? 264 ASP B OD1 1 
ATOM   5957  O OD2 . ASP B 1 264 ? -15.241 39.820  -51.591 1.00 56.91  ? 264 ASP B OD2 1 
ATOM   5958  N N   . VAL B 1 265 ? -9.566  40.533  -49.541 1.00 55.13  ? 265 VAL B N   1 
ATOM   5959  C CA  . VAL B 1 265 ? -8.151  40.279  -49.712 1.00 56.26  ? 265 VAL B CA  1 
ATOM   5960  C C   . VAL B 1 265 ? -7.896  38.878  -49.188 1.00 58.60  ? 265 VAL B C   1 
ATOM   5961  O O   . VAL B 1 265 ? -8.295  38.578  -48.064 1.00 56.93  ? 265 VAL B O   1 
ATOM   5962  C CB  . VAL B 1 265 ? -7.262  41.316  -48.991 1.00 55.22  ? 265 VAL B CB  1 
ATOM   5963  C CG1 . VAL B 1 265 ? -5.832  40.819  -48.734 1.00 51.22  ? 265 VAL B CG1 1 
ATOM   5964  C CG2 . VAL B 1 265 ? -7.253  42.644  -49.741 1.00 57.79  ? 265 VAL B CG2 1 
ATOM   5965  N N   . PHE B 1 266 ? -7.215  38.069  -50.012 1.00 58.75  ? 266 PHE B N   1 
ATOM   5966  C CA  . PHE B 1 266 ? -6.758  36.746  -49.620 1.00 59.01  ? 266 PHE B CA  1 
ATOM   5967  C C   . PHE B 1 266 ? -5.392  36.882  -48.947 1.00 52.09  ? 266 PHE B C   1 
ATOM   5968  O O   . PHE B 1 266 ? -4.526  37.599  -49.446 1.00 55.77  ? 266 PHE B O   1 
ATOM   5969  C CB  . PHE B 1 266 ? -6.713  35.761  -50.802 1.00 58.79  ? 266 PHE B CB  1 
ATOM   5970  C CG  . PHE B 1 266 ? -6.049  34.438  -50.439 1.00 56.18  ? 266 PHE B CG  1 
ATOM   5971  C CD1 . PHE B 1 266 ? -6.768  33.438  -49.794 1.00 55.45  ? 266 PHE B CD1 1 
ATOM   5972  C CD2 . PHE B 1 266 ? -4.701  34.216  -50.710 1.00 54.60  ? 266 PHE B CD2 1 
ATOM   5973  C CE1 . PHE B 1 266 ? -6.149  32.250  -49.432 1.00 58.99  ? 266 PHE B CE1 1 
ATOM   5974  C CE2 . PHE B 1 266 ? -4.091  33.019  -50.363 1.00 60.31  ? 266 PHE B CE2 1 
ATOM   5975  C CZ  . PHE B 1 266 ? -4.813  32.043  -49.714 1.00 60.63  ? 266 PHE B CZ  1 
ATOM   5976  N N   . ILE B 1 267 ? -5.249  36.195  -47.801 1.00 53.55  ? 267 ILE B N   1 
ATOM   5977  C CA  . ILE B 1 267 ? -4.001  36.036  -47.067 1.00 53.59  ? 267 ILE B CA  1 
ATOM   5978  C C   . ILE B 1 267 ? -3.766  34.531  -46.962 1.00 57.39  ? 267 ILE B C   1 
ATOM   5979  O O   . ILE B 1 267 ? -4.639  33.829  -46.447 1.00 53.20  ? 267 ILE B O   1 
ATOM   5980  C CB  . ILE B 1 267 ? -4.074  36.675  -45.659 1.00 51.94  ? 267 ILE B CB  1 
ATOM   5981  C CG1 . ILE B 1 267 ? -4.469  38.174  -45.710 1.00 56.84  ? 267 ILE B CG1 1 
ATOM   5982  C CG2 . ILE B 1 267 ? -2.774  36.463  -44.873 1.00 47.64  ? 267 ILE B CG2 1 
ATOM   5983  C CD1 . ILE B 1 267 ? -4.784  38.793  -44.353 1.00 59.40  ? 267 ILE B CD1 1 
ATOM   5984  N N   . PRO B 1 268 ? -2.624  33.997  -47.466 1.00 55.75  ? 268 PRO B N   1 
ATOM   5985  C CA  . PRO B 1 268 ? -2.283  32.580  -47.296 1.00 59.15  ? 268 PRO B CA  1 
ATOM   5986  C C   . PRO B 1 268 ? -1.871  32.275  -45.858 1.00 56.79  ? 268 PRO B C   1 
ATOM   5987  O O   . PRO B 1 268 ? -1.354  33.163  -45.185 1.00 54.01  ? 268 PRO B O   1 
ATOM   5988  C CB  . PRO B 1 268 ? -1.123  32.389  -48.287 1.00 55.77  ? 268 PRO B CB  1 
ATOM   5989  C CG  . PRO B 1 268 ? -0.433  33.739  -48.277 1.00 61.55  ? 268 PRO B CG  1 
ATOM   5990  C CD  . PRO B 1 268 ? -1.602  34.726  -48.234 1.00 58.22  ? 268 PRO B CD  1 
ATOM   5991  N N   . TRP B 1 269 ? -2.069  31.013  -45.432 1.00 53.16  ? 269 TRP B N   1 
ATOM   5992  C CA  . TRP B 1 269 ? -1.856  30.576  -44.057 1.00 52.57  ? 269 TRP B CA  1 
ATOM   5993  C C   . TRP B 1 269 ? -0.458  30.908  -43.544 1.00 49.14  ? 269 TRP B C   1 
ATOM   5994  O O   . TRP B 1 269 ? -0.298  31.183  -42.356 1.00 44.91  ? 269 TRP B O   1 
ATOM   5995  C CB  . TRP B 1 269 ? -2.148  29.073  -43.892 1.00 55.44  ? 269 TRP B CB  1 
ATOM   5996  C CG  . TRP B 1 269 ? -3.622  28.773  -43.795 1.00 58.26  ? 269 TRP B CG  1 
ATOM   5997  C CD1 . TRP B 1 269 ? -4.370  28.050  -44.679 1.00 58.44  ? 269 TRP B CD1 1 
ATOM   5998  C CD2 . TRP B 1 269 ? -4.544  29.261  -42.790 1.00 54.11  ? 269 TRP B CD2 1 
ATOM   5999  N NE1 . TRP B 1 269 ? -5.682  28.031  -44.287 1.00 56.95  ? 269 TRP B NE1 1 
ATOM   6000  C CE2 . TRP B 1 269 ? -5.823  28.769  -43.136 1.00 58.08  ? 269 TRP B CE2 1 
ATOM   6001  C CE3 . TRP B 1 269 ? -4.418  30.058  -41.643 1.00 53.60  ? 269 TRP B CE3 1 
ATOM   6002  C CZ2 . TRP B 1 269 ? -6.959  29.052  -42.374 1.00 57.03  ? 269 TRP B CZ2 1 
ATOM   6003  C CZ3 . TRP B 1 269 ? -5.541  30.326  -40.885 1.00 56.19  ? 269 TRP B CZ3 1 
ATOM   6004  C CH2 . TRP B 1 269 ? -6.799  29.839  -41.254 1.00 51.16  ? 269 TRP B CH2 1 
ATOM   6005  N N   . GLU B 1 270 ? 0.551   30.872  -44.416 1.00 50.81  ? 270 GLU B N   1 
ATOM   6006  C CA  . GLU B 1 270 ? 1.924   31.042  -43.962 1.00 58.03  ? 270 GLU B CA  1 
ATOM   6007  C C   . GLU B 1 270 ? 2.168   32.501  -43.562 1.00 57.91  ? 270 GLU B C   1 
ATOM   6008  O O   . GLU B 1 270 ? 3.134   32.786  -42.853 1.00 60.13  ? 270 GLU B O   1 
ATOM   6009  C CB  . GLU B 1 270 ? 2.951   30.481  -44.955 1.00 62.56  ? 270 GLU B CB  1 
ATOM   6010  C CG  . GLU B 1 270 ? 2.784   30.963  -46.397 1.00 79.37  ? 270 GLU B CG  1 
ATOM   6011  C CD  . GLU B 1 270 ? 2.149   30.010  -47.413 1.00 86.71  ? 270 GLU B CD  1 
ATOM   6012  O OE1 . GLU B 1 270 ? 1.144   29.300  -47.115 1.00 65.56  ? 270 GLU B OE1 1 
ATOM   6013  O OE2 . GLU B 1 270 ? 2.671   30.031  -48.557 1.00 88.36  ? 270 GLU B OE2 1 
ATOM   6014  N N   . ASN B 1 271 ? 1.287   33.414  -43.998 1.00 53.73  ? 271 ASN B N   1 
ATOM   6015  C CA  . ASN B 1 271 ? 1.408   34.835  -43.684 1.00 61.00  ? 271 ASN B CA  1 
ATOM   6016  C C   . ASN B 1 271 ? 0.606   35.222  -42.439 1.00 67.01  ? 271 ASN B C   1 
ATOM   6017  O O   . ASN B 1 271 ? 0.683   36.372  -41.995 1.00 65.56  ? 271 ASN B O   1 
ATOM   6018  C CB  . ASN B 1 271 ? 0.968   35.716  -44.849 1.00 55.23  ? 271 ASN B CB  1 
ATOM   6019  C CG  . ASN B 1 271 ? 2.051   35.861  -45.891 1.00 60.12  ? 271 ASN B CG  1 
ATOM   6020  O OD1 . ASN B 1 271 ? 3.212   35.496  -45.648 1.00 56.32  ? 271 ASN B OD1 1 
ATOM   6021  N ND2 . ASN B 1 271 ? 1.695   36.431  -47.032 1.00 61.58  ? 271 ASN B ND2 1 
ATOM   6022  N N   . VAL B 1 272 ? -0.162  34.267  -41.894 1.00 56.45  ? 272 VAL B N   1 
ATOM   6023  C CA  . VAL B 1 272 ? -0.996  34.506  -40.730 1.00 52.62  ? 272 VAL B CA  1 
ATOM   6024  C C   . VAL B 1 272 ? -0.160  34.183  -39.494 1.00 54.59  ? 272 VAL B C   1 
ATOM   6025  O O   . VAL B 1 272 ? 0.701   33.317  -39.541 1.00 45.16  ? 272 VAL B O   1 
ATOM   6026  C CB  . VAL B 1 272 ? -2.288  33.680  -40.834 1.00 48.45  ? 272 VAL B CB  1 
ATOM   6027  C CG1 . VAL B 1 272 ? -3.265  33.951  -39.695 1.00 49.31  ? 272 VAL B CG1 1 
ATOM   6028  C CG2 . VAL B 1 272 ? -2.982  33.927  -42.169 1.00 50.96  ? 272 VAL B CG2 1 
ATOM   6029  N N   . GLN B 1 273 ? -0.339  34.983  -38.441 1.00 58.21  ? 273 GLN B N   1 
ATOM   6030  C CA  . GLN B 1 273 ? 0.380   34.816  -37.187 1.00 60.28  ? 273 GLN B CA  1 
ATOM   6031  C C   . GLN B 1 273 ? -0.566  34.452  -36.036 1.00 55.72  ? 273 GLN B C   1 
ATOM   6032  O O   . GLN B 1 273 ? -0.101  33.945  -35.017 1.00 55.28  ? 273 GLN B O   1 
ATOM   6033  C CB  . GLN B 1 273 ? 1.066   36.116  -36.779 1.00 57.73  ? 273 GLN B CB  1 
ATOM   6034  C CG  . GLN B 1 273 ? 1.861   36.798  -37.885 1.00 59.06  ? 273 GLN B CG  1 
ATOM   6035  C CD  . GLN B 1 273 ? 2.115   38.259  -37.566 1.00 58.16  ? 273 GLN B CD  1 
ATOM   6036  O OE1 . GLN B 1 273 ? 1.244   38.953  -37.015 1.00 52.58  ? 273 GLN B OE1 1 
ATOM   6037  N NE2 . GLN B 1 273 ? 3.321   38.723  -37.859 1.00 53.78  ? 273 GLN B NE2 1 
ATOM   6038  N N   . HIS B 1 274 ? -1.867  34.762  -36.184 1.00 54.08  ? 274 HIS B N   1 
ATOM   6039  C CA  . HIS B 1 274 ? -2.898  34.432  -35.205 1.00 56.68  ? 274 HIS B CA  1 
ATOM   6040  C C   . HIS B 1 274 ? -4.266  34.874  -35.725 1.00 55.95  ? 274 HIS B C   1 
ATOM   6041  O O   . HIS B 1 274 ? -4.378  35.906  -36.375 1.00 61.04  ? 274 HIS B O   1 
ATOM   6042  C CB  . HIS B 1 274 ? -2.644  35.105  -33.851 1.00 52.82  ? 274 HIS B CB  1 
ATOM   6043  C CG  . HIS B 1 274 ? -3.807  34.962  -32.941 1.00 55.11  ? 274 HIS B CG  1 
ATOM   6044  N ND1 . HIS B 1 274 ? -3.798  34.107  -31.861 1.00 61.21  ? 274 HIS B ND1 1 
ATOM   6045  C CD2 . HIS B 1 274 ? -5.022  35.531  -32.959 1.00 57.57  ? 274 HIS B CD2 1 
ATOM   6046  C CE1 . HIS B 1 274 ? -4.976  34.165  -31.254 1.00 62.25  ? 274 HIS B CE1 1 
ATOM   6047  N NE2 . HIS B 1 274 ? -5.740  35.022  -31.907 1.00 60.51  ? 274 HIS B NE2 1 
ATOM   6048  N N   . ILE B 1 275 ? -5.307  34.086  -35.447 1.00 53.01  ? 275 ILE B N   1 
ATOM   6049  C CA  . ILE B 1 275 ? -6.678  34.540  -35.644 1.00 57.55  ? 275 ILE B CA  1 
ATOM   6050  C C   . ILE B 1 275 ? -7.549  34.018  -34.502 1.00 57.15  ? 275 ILE B C   1 
ATOM   6051  O O   . ILE B 1 275 ? -7.196  33.044  -33.845 1.00 64.61  ? 275 ILE B O   1 
ATOM   6052  C CB  . ILE B 1 275 ? -7.254  34.099  -37.012 1.00 62.20  ? 275 ILE B CB  1 
ATOM   6053  C CG1 . ILE B 1 275 ? -7.109  32.580  -37.249 1.00 62.30  ? 275 ILE B CG1 1 
ATOM   6054  C CG2 . ILE B 1 275 ? -6.651  34.908  -38.164 1.00 61.82  ? 275 ILE B CG2 1 
ATOM   6055  C CD1 . ILE B 1 275 ? -8.204  31.970  -38.109 1.00 63.26  ? 275 ILE B CD1 1 
ATOM   6056  N N   . GLY B 1 276 ? -8.686  34.681  -34.267 1.00 57.10  ? 276 GLY B N   1 
ATOM   6057  C CA  . GLY B 1 276 ? -9.842  34.039  -33.661 1.00 53.17  ? 276 GLY B CA  1 
ATOM   6058  C C   . GLY B 1 276 ? -10.017 34.283  -32.160 1.00 54.86  ? 276 GLY B C   1 
ATOM   6059  O O   . GLY B 1 276 ? -11.102 34.017  -31.652 1.00 54.23  ? 276 GLY B O   1 
ATOM   6060  N N   . ASN B 1 277 ? -8.992  34.786  -31.453 1.00 54.74  ? 277 ASN B N   1 
ATOM   6061  C CA  . ASN B 1 277 ? -9.034  34.811  -29.997 1.00 58.97  ? 277 ASN B CA  1 
ATOM   6062  C C   . ASN B 1 277 ? -8.919  36.243  -29.464 1.00 62.70  ? 277 ASN B C   1 
ATOM   6063  O O   . ASN B 1 277 ? -7.823  36.716  -29.133 1.00 51.49  ? 277 ASN B O   1 
ATOM   6064  C CB  . ASN B 1 277 ? -7.971  33.903  -29.382 1.00 58.10  ? 277 ASN B CB  1 
ATOM   6065  C CG  . ASN B 1 277 ? -8.141  33.770  -27.883 1.00 66.34  ? 277 ASN B CG  1 
ATOM   6066  O OD1 . ASN B 1 277 ? -8.892  34.545  -27.281 1.00 65.20  ? 277 ASN B OD1 1 
ATOM   6067  N ND2 . ASN B 1 277 ? -7.470  32.809  -27.255 1.00 63.72  ? 277 ASN B ND2 1 
ATOM   6068  N N   . PRO B 1 278 ? -10.069 36.932  -29.263 1.00 62.86  ? 278 PRO B N   1 
ATOM   6069  C CA  . PRO B 1 278 ? -10.105 38.278  -28.678 1.00 67.29  ? 278 PRO B CA  1 
ATOM   6070  C C   . PRO B 1 278 ? -9.238  38.546  -27.450 1.00 64.56  ? 278 PRO B C   1 
ATOM   6071  O O   . PRO B 1 278 ? -8.751  39.668  -27.292 1.00 65.61  ? 278 PRO B O   1 
ATOM   6072  C CB  . PRO B 1 278 ? -11.591 38.482  -28.336 1.00 65.69  ? 278 PRO B CB  1 
ATOM   6073  C CG  . PRO B 1 278 ? -12.313 37.640  -29.357 1.00 68.93  ? 278 PRO B CG  1 
ATOM   6074  C CD  . PRO B 1 278 ? -11.408 36.444  -29.613 1.00 63.76  ? 278 PRO B CD  1 
ATOM   6075  N N   . ASP B 1 279 ? -9.056  37.529  -26.592 1.00 60.21  ? 279 ASP B N   1 
ATOM   6076  C CA  . ASP B 1 279 ? -8.317  37.696  -25.344 1.00 63.10  ? 279 ASP B CA  1 
ATOM   6077  C C   . ASP B 1 279 ? -6.811  37.653  -25.603 1.00 61.04  ? 279 ASP B C   1 
ATOM   6078  O O   . ASP B 1 279 ? -6.022  38.158  -24.802 1.00 53.84  ? 279 ASP B O   1 
ATOM   6079  C CB  . ASP B 1 279 ? -8.789  36.720  -24.278 1.00 75.21  ? 279 ASP B CB  1 
ATOM   6080  C CG  . ASP B 1 279 ? -10.216 36.960  -23.792 1.00 83.82  ? 279 ASP B CG  1 
ATOM   6081  O OD1 . ASP B 1 279 ? -11.168 36.830  -24.611 1.00 79.70  ? 279 ASP B OD1 1 
ATOM   6082  O OD2 . ASP B 1 279 ? -10.363 37.303  -22.601 1.00 79.46  ? 279 ASP B OD2 1 
ATOM   6083  N N   . HIS B 1 280 ? -6.415  37.057  -26.736 1.00 65.17  ? 280 HIS B N   1 
ATOM   6084  C CA  . HIS B 1 280 ? -5.052  37.196  -27.215 1.00 60.36  ? 280 HIS B CA  1 
ATOM   6085  C C   . HIS B 1 280 ? -4.727  38.677  -27.429 1.00 58.48  ? 280 HIS B C   1 
ATOM   6086  O O   . HIS B 1 280 ? -3.611  39.120  -27.158 1.00 53.90  ? 280 HIS B O   1 
ATOM   6087  C CB  . HIS B 1 280 ? -4.852  36.426  -28.523 1.00 54.48  ? 280 HIS B CB  1 
ATOM   6088  C CG  . HIS B 1 280 ? -3.427  36.391  -28.929 1.00 50.05  ? 280 HIS B CG  1 
ATOM   6089  N ND1 . HIS B 1 280 ? -2.505  35.651  -28.221 1.00 51.32  ? 280 HIS B ND1 1 
ATOM   6090  C CD2 . HIS B 1 280 ? -2.744  37.033  -29.889 1.00 52.68  ? 280 HIS B CD2 1 
ATOM   6091  C CE1 . HIS B 1 280 ? -1.307  35.805  -28.782 1.00 52.48  ? 280 HIS B CE1 1 
ATOM   6092  N NE2 . HIS B 1 280 ? -1.427  36.649  -29.794 1.00 48.07  ? 280 HIS B NE2 1 
ATOM   6093  N N   . ALA B 1 281 ? -5.716  39.430  -27.925 1.00 53.76  ? 281 ALA B N   1 
ATOM   6094  C CA  . ALA B 1 281 ? -5.532  40.827  -28.286 1.00 61.88  ? 281 ALA B CA  1 
ATOM   6095  C C   . ALA B 1 281 ? -5.460  41.727  -27.051 1.00 64.54  ? 281 ALA B C   1 
ATOM   6096  O O   . ALA B 1 281 ? -5.186  42.924  -27.182 1.00 63.24  ? 281 ALA B O   1 
ATOM   6097  C CB  . ALA B 1 281 ? -6.650  41.264  -29.215 1.00 61.26  ? 281 ALA B CB  1 
ATOM   6098  N N   . LYS B 1 282 ? -5.718  41.153  -25.864 1.00 63.09  ? 282 LYS B N   1 
ATOM   6099  C CA  . LYS B 1 282 ? -5.770  41.923  -24.634 1.00 68.82  ? 282 LYS B CA  1 
ATOM   6100  C C   . LYS B 1 282 ? -4.374  42.076  -24.047 1.00 71.86  ? 282 LYS B C   1 
ATOM   6101  O O   . LYS B 1 282 ? -4.058  43.136  -23.512 1.00 96.72  ? 282 LYS B O   1 
ATOM   6102  C CB  . LYS B 1 282 ? -6.665  41.300  -23.557 1.00 73.10  ? 282 LYS B CB  1 
ATOM   6103  C CG  . LYS B 1 282 ? -8.158  41.447  -23.768 1.00 75.51  ? 282 LYS B CG  1 
ATOM   6104  C CD  . LYS B 1 282 ? -9.000  40.864  -22.636 1.00 79.05  ? 282 LYS B CD  1 
ATOM   6105  C CE  . LYS B 1 282 ? -10.413 40.639  -23.085 1.00 81.60  ? 282 LYS B CE  1 
ATOM   6106  N NZ  . LYS B 1 282 ? -11.279 40.098  -22.040 1.00 86.54  ? 282 LYS B NZ  1 
ATOM   6107  N N   . TRP B 1 283 ? -3.561  41.016  -24.122 1.00 73.43  ? 283 TRP B N   1 
ATOM   6108  C CA  . TRP B 1 283 ? -2.281  40.983  -23.431 1.00 77.98  ? 283 TRP B CA  1 
ATOM   6109  C C   . TRP B 1 283 ? -1.130  41.153  -24.431 1.00 71.74  ? 283 TRP B C   1 
ATOM   6110  O O   . TRP B 1 283 ? -0.198  41.902  -24.162 1.00 74.71  ? 283 TRP B O   1 
ATOM   6111  C CB  . TRP B 1 283 ? -2.156  39.698  -22.582 1.00 95.14  ? 283 TRP B CB  1 
ATOM   6112  C CG  . TRP B 1 283 ? -3.356  39.362  -21.713 1.00 122.45 ? 283 TRP B CG  1 
ATOM   6113  C CD1 . TRP B 1 283 ? -3.996  38.152  -21.666 1.00 120.46 ? 283 TRP B CD1 1 
ATOM   6114  C CD2 . TRP B 1 283 ? -4.064  40.212  -20.767 1.00 134.43 ? 283 TRP B CD2 1 
ATOM   6115  N NE1 . TRP B 1 283 ? -5.046  38.187  -20.784 1.00 115.46 ? 283 TRP B NE1 1 
ATOM   6116  C CE2 . TRP B 1 283 ? -5.115  39.433  -20.215 1.00 130.72 ? 283 TRP B CE2 1 
ATOM   6117  C CE3 . TRP B 1 283 ? -3.927  41.544  -20.338 1.00 123.07 ? 283 TRP B CE3 1 
ATOM   6118  C CZ2 . TRP B 1 283 ? -6.008  39.944  -19.268 1.00 122.61 ? 283 TRP B CZ2 1 
ATOM   6119  C CZ3 . TRP B 1 283 ? -4.813  42.048  -19.406 1.00 116.43 ? 283 TRP B CZ3 1 
ATOM   6120  C CH2 . TRP B 1 283 ? -5.841  41.258  -18.883 1.00 119.66 ? 283 TRP B CH2 1 
ATOM   6121  N N   . TYR B 1 284 ? -1.207  40.518  -25.613 1.00 64.70  ? 284 TYR B N   1 
ATOM   6122  C CA  . TYR B 1 284 ? -0.025  40.284  -26.439 1.00 61.25  ? 284 TYR B CA  1 
ATOM   6123  C C   . TYR B 1 284 ? 0.381   41.492  -27.293 1.00 58.10  ? 284 TYR B C   1 
ATOM   6124  O O   . TYR B 1 284 ? 1.584   41.784  -27.361 1.00 54.37  ? 284 TYR B O   1 
ATOM   6125  C CB  . TYR B 1 284 ? -0.164  38.990  -27.256 1.00 60.39  ? 284 TYR B CB  1 
ATOM   6126  C CG  . TYR B 1 284 ? 0.230   37.787  -26.413 1.00 56.41  ? 284 TYR B CG  1 
ATOM   6127  C CD1 . TYR B 1 284 ? 1.568   37.413  -26.284 1.00 57.36  ? 284 TYR B CD1 1 
ATOM   6128  C CD2 . TYR B 1 284 ? -0.715  37.096  -25.659 1.00 57.14  ? 284 TYR B CD2 1 
ATOM   6129  C CE1 . TYR B 1 284 ? 1.938   36.342  -25.483 1.00 58.02  ? 284 TYR B CE1 1 
ATOM   6130  C CE2 . TYR B 1 284 ? -0.356  36.029  -24.848 1.00 56.72  ? 284 TYR B CE2 1 
ATOM   6131  C CZ  . TYR B 1 284 ? 0.974   35.649  -24.764 1.00 57.07  ? 284 TYR B CZ  1 
ATOM   6132  O OH  . TYR B 1 284 ? 1.333   34.607  -23.957 1.00 54.82  ? 284 TYR B OH  1 
ATOM   6133  N N   . PRO B 1 285 ? -0.523  42.216  -28.010 1.00 60.04  ? 285 PRO B N   1 
ATOM   6134  C CA  . PRO B 1 285 ? -0.086  43.371  -28.813 1.00 63.80  ? 285 PRO B CA  1 
ATOM   6135  C C   . PRO B 1 285 ? 0.457   44.549  -27.999 1.00 60.95  ? 285 PRO B C   1 
ATOM   6136  O O   . PRO B 1 285 ? 1.200   45.372  -28.535 1.00 58.07  ? 285 PRO B O   1 
ATOM   6137  C CB  . PRO B 1 285 ? -1.327  43.752  -29.641 1.00 59.66  ? 285 PRO B CB  1 
ATOM   6138  C CG  . PRO B 1 285 ? -2.487  43.221  -28.827 1.00 61.48  ? 285 PRO B CG  1 
ATOM   6139  C CD  . PRO B 1 285 ? -1.970  41.965  -28.131 1.00 57.89  ? 285 PRO B CD  1 
ATOM   6140  N N   . GLN B 1 286 ? 0.099   44.585  -26.704 1.00 62.21  ? 286 GLN B N   1 
ATOM   6141  C CA  . GLN B 1 286 ? 0.594   45.554  -25.733 1.00 60.24  ? 286 GLN B CA  1 
ATOM   6142  C C   . GLN B 1 286 ? 2.092   45.354  -25.512 1.00 56.61  ? 286 GLN B C   1 
ATOM   6143  O O   . GLN B 1 286 ? 2.818   46.326  -25.316 1.00 56.05  ? 286 GLN B O   1 
ATOM   6144  C CB  . GLN B 1 286 ? -0.181  45.457  -24.412 1.00 62.71  ? 286 GLN B CB  1 
ATOM   6145  C CG  . GLN B 1 286 ? -1.628  45.960  -24.478 1.00 72.76  ? 286 GLN B CG  1 
ATOM   6146  C CD  . GLN B 1 286 ? -2.592  45.071  -25.252 1.00 78.34  ? 286 GLN B CD  1 
ATOM   6147  O OE1 . GLN B 1 286 ? -2.285  43.919  -25.582 1.00 71.06  ? 286 GLN B OE1 1 
ATOM   6148  N NE2 . GLN B 1 286 ? -3.781  45.585  -25.551 1.00 72.23  ? 286 GLN B NE2 1 
ATOM   6149  N N   . ARG B 1 287 ? 2.564   44.099  -25.552 1.00 56.08  ? 287 ARG B N   1 
ATOM   6150  C CA  . ARG B 1 287 ? 3.994   43.827  -25.423 1.00 62.41  ? 287 ARG B CA  1 
ATOM   6151  C C   . ARG B 1 287 ? 4.724   44.228  -26.703 1.00 55.09  ? 287 ARG B C   1 
ATOM   6152  O O   . ARG B 1 287 ? 5.922   44.517  -26.674 1.00 52.71  ? 287 ARG B O   1 
ATOM   6153  C CB  . ARG B 1 287 ? 4.351   42.357  -25.180 1.00 71.38  ? 287 ARG B CB  1 
ATOM   6154  C CG  . ARG B 1 287 ? 3.851   41.763  -23.873 1.00 81.27  ? 287 ARG B CG  1 
ATOM   6155  C CD  . ARG B 1 287 ? 3.987   40.244  -23.887 1.00 88.24  ? 287 ARG B CD  1 
ATOM   6156  N NE  . ARG B 1 287 ? 2.761   39.697  -23.298 1.00 99.83  ? 287 ARG B NE  1 
ATOM   6157  C CZ  . ARG B 1 287 ? 2.690   38.803  -22.329 1.00 94.78  ? 287 ARG B CZ  1 
ATOM   6158  N NH1 . ARG B 1 287 ? 3.770   38.120  -21.998 1.00 90.14  ? 287 ARG B NH1 1 
ATOM   6159  N NH2 . ARG B 1 287 ? 1.525   38.572  -21.742 1.00 94.62  ? 287 ARG B NH2 1 
ATOM   6160  N N   . GLN B 1 288 ? 4.003   44.197  -27.830 1.00 51.54  ? 288 GLN B N   1 
ATOM   6161  C CA  . GLN B 1 288 ? 4.557   44.661  -29.095 1.00 56.92  ? 288 GLN B CA  1 
ATOM   6162  C C   . GLN B 1 288 ? 4.704   46.185  -29.041 1.00 53.45  ? 288 GLN B C   1 
ATOM   6163  O O   . GLN B 1 288 ? 5.762   46.717  -29.360 1.00 51.55  ? 288 GLN B O   1 
ATOM   6164  C CB  . GLN B 1 288 ? 3.703   44.267  -30.305 1.00 51.18  ? 288 GLN B CB  1 
ATOM   6165  C CG  . GLN B 1 288 ? 3.433   42.772  -30.457 1.00 51.11  ? 288 GLN B CG  1 
ATOM   6166  C CD  . GLN B 1 288 ? 2.661   42.489  -31.723 1.00 54.31  ? 288 GLN B CD  1 
ATOM   6167  O OE1 . GLN B 1 288 ? 1.424   42.399  -31.744 1.00 51.83  ? 288 GLN B OE1 1 
ATOM   6168  N NE2 . GLN B 1 288 ? 3.396   42.474  -32.820 1.00 53.30  ? 288 GLN B NE2 1 
ATOM   6169  N N   . PHE B 1 289 ? 3.649   46.869  -28.582 1.00 53.73  ? 289 PHE B N   1 
ATOM   6170  C CA  . PHE B 1 289 ? 3.630   48.324  -28.574 1.00 66.58  ? 289 PHE B CA  1 
ATOM   6171  C C   . PHE B 1 289 ? 4.607   48.860  -27.527 1.00 60.15  ? 289 PHE B C   1 
ATOM   6172  O O   . PHE B 1 289 ? 5.037   49.996  -27.669 1.00 62.35  ? 289 PHE B O   1 
ATOM   6173  C CB  . PHE B 1 289 ? 2.194   48.879  -28.524 1.00 74.86  ? 289 PHE B CB  1 
ATOM   6174  C CG  . PHE B 1 289 ? 1.684   49.119  -29.942 1.00 85.49  ? 289 PHE B CG  1 
ATOM   6175  C CD1 . PHE B 1 289 ? 1.261   48.058  -30.739 1.00 87.75  ? 289 PHE B CD1 1 
ATOM   6176  C CD2 . PHE B 1 289 ? 1.722   50.391  -30.512 1.00 103.53 ? 289 PHE B CD2 1 
ATOM   6177  C CE1 . PHE B 1 289 ? 0.853   48.270  -32.050 1.00 94.85  ? 289 PHE B CE1 1 
ATOM   6178  C CE2 . PHE B 1 289 ? 1.311   50.600  -31.824 1.00 108.09 ? 289 PHE B CE2 1 
ATOM   6179  C CZ  . PHE B 1 289 ? 0.874   49.539  -32.589 1.00 107.36 ? 289 PHE B CZ  1 
ATOM   6180  N N   . ASP B 1 290 ? 5.033   48.040  -26.551 1.00 55.78  ? 290 ASP B N   1 
ATOM   6181  C CA  . ASP B 1 290 ? 6.084   48.452  -25.631 1.00 57.58  ? 290 ASP B CA  1 
ATOM   6182  C C   . ASP B 1 290 ? 7.360   48.866  -26.372 1.00 58.85  ? 290 ASP B C   1 
ATOM   6183  O O   . ASP B 1 290 ? 8.087   49.756  -25.912 1.00 51.67  ? 290 ASP B O   1 
ATOM   6184  C CB  . ASP B 1 290 ? 6.421   47.367  -24.616 1.00 63.15  ? 290 ASP B CB  1 
ATOM   6185  C CG  . ASP B 1 290 ? 5.434   47.198  -23.468 1.00 57.98  ? 290 ASP B CG  1 
ATOM   6186  O OD1 . ASP B 1 290 ? 4.575   48.075  -23.311 1.00 56.46  ? 290 ASP B OD1 1 
ATOM   6187  O OD2 . ASP B 1 290 ? 5.522   46.176  -22.762 1.00 59.93  ? 290 ASP B OD2 1 
ATOM   6188  N N   . TRP B 1 291 ? 7.654   48.200  -27.502 1.00 54.67  ? 291 TRP B N   1 
ATOM   6189  C CA  . TRP B 1 291 ? 8.869   48.489  -28.255 1.00 53.39  ? 291 TRP B CA  1 
ATOM   6190  C C   . TRP B 1 291 ? 8.735   49.786  -29.069 1.00 52.30  ? 291 TRP B C   1 
ATOM   6191  O O   . TRP B 1 291 ? 9.704   50.519  -29.258 1.00 47.85  ? 291 TRP B O   1 
ATOM   6192  C CB  . TRP B 1 291 ? 9.226   47.270  -29.119 1.00 55.16  ? 291 TRP B CB  1 
ATOM   6193  C CG  . TRP B 1 291 ? 9.765   46.161  -28.259 1.00 55.99  ? 291 TRP B CG  1 
ATOM   6194  C CD1 . TRP B 1 291 ? 9.076   45.131  -27.687 1.00 50.82  ? 291 TRP B CD1 1 
ATOM   6195  C CD2 . TRP B 1 291 ? 11.126  46.061  -27.790 1.00 54.86  ? 291 TRP B CD2 1 
ATOM   6196  N NE1 . TRP B 1 291 ? 9.923   44.387  -26.912 1.00 56.08  ? 291 TRP B NE1 1 
ATOM   6197  C CE2 . TRP B 1 291 ? 11.181  44.929  -26.951 1.00 53.72  ? 291 TRP B CE2 1 
ATOM   6198  C CE3 . TRP B 1 291 ? 12.293  46.812  -28.006 1.00 55.10  ? 291 TRP B CE3 1 
ATOM   6199  C CZ2 . TRP B 1 291 ? 12.360  44.532  -26.326 1.00 53.80  ? 291 TRP B CZ2 1 
ATOM   6200  C CZ3 . TRP B 1 291 ? 13.458  46.411  -27.395 1.00 55.04  ? 291 TRP B CZ3 1 
ATOM   6201  C CH2 . TRP B 1 291 ? 13.483  45.292  -26.561 1.00 54.93  ? 291 TRP B CH2 1 
ATOM   6202  N N   . VAL B 1 292 ? 7.532   50.069  -29.568 1.00 44.80  ? 292 VAL B N   1 
ATOM   6203  C CA  . VAL B 1 292 ? 7.269   51.333  -30.226 1.00 55.53  ? 292 VAL B CA  1 
ATOM   6204  C C   . VAL B 1 292 ? 7.539   52.447  -29.216 1.00 54.00  ? 292 VAL B C   1 
ATOM   6205  O O   . VAL B 1 292 ? 8.309   53.358  -29.477 1.00 57.56  ? 292 VAL B O   1 
ATOM   6206  C CB  . VAL B 1 292 ? 5.809   51.358  -30.735 1.00 66.82  ? 292 VAL B CB  1 
ATOM   6207  C CG1 . VAL B 1 292 ? 5.379   52.739  -31.227 1.00 65.40  ? 292 VAL B CG1 1 
ATOM   6208  C CG2 . VAL B 1 292 ? 5.557   50.285  -31.799 1.00 72.56  ? 292 VAL B CG2 1 
ATOM   6209  N N   . HIS B 1 293 ? 6.916   52.315  -28.045 1.00 51.34  ? 293 HIS B N   1 
ATOM   6210  C CA  . HIS B 1 293 ? 7.020   53.270  -26.954 1.00 56.31  ? 293 HIS B CA  1 
ATOM   6211  C C   . HIS B 1 293 ? 8.471   53.584  -26.579 1.00 52.43  ? 293 HIS B C   1 
ATOM   6212  O O   . HIS B 1 293 ? 8.785   54.739  -26.322 1.00 51.08  ? 293 HIS B O   1 
ATOM   6213  C CB  . HIS B 1 293 ? 6.210   52.766  -25.755 1.00 51.49  ? 293 HIS B CB  1 
ATOM   6214  C CG  . HIS B 1 293 ? 4.750   52.687  -26.052 1.00 48.33  ? 293 HIS B CG  1 
ATOM   6215  N ND1 . HIS B 1 293 ? 3.892   51.904  -25.315 1.00 42.56  ? 293 HIS B ND1 1 
ATOM   6216  C CD2 . HIS B 1 293 ? 4.007   53.293  -26.996 1.00 49.65  ? 293 HIS B CD2 1 
ATOM   6217  C CE1 . HIS B 1 293 ? 2.667   52.023  -25.813 1.00 50.22  ? 293 HIS B CE1 1 
ATOM   6218  N NE2 . HIS B 1 293 ? 2.718   52.855  -26.839 1.00 55.28  ? 293 HIS B NE2 1 
ATOM   6219  N N   . ILE B 1 294 ? 9.334   52.563  -26.527 1.00 51.47  ? 294 ILE B N   1 
ATOM   6220  C CA  . ILE B 1 294 ? 10.743  52.735  -26.188 1.00 51.23  ? 294 ILE B CA  1 
ATOM   6221  C C   . ILE B 1 294 ? 11.411  53.662  -27.204 1.00 52.62  ? 294 ILE B C   1 
ATOM   6222  O O   . ILE B 1 294 ? 12.090  54.621  -26.838 1.00 44.01  ? 294 ILE B O   1 
ATOM   6223  C CB  . ILE B 1 294 ? 11.443  51.363  -26.132 1.00 52.75  ? 294 ILE B CB  1 
ATOM   6224  C CG1 . ILE B 1 294 ? 11.033  50.591  -24.864 1.00 55.91  ? 294 ILE B CG1 1 
ATOM   6225  C CG2 . ILE B 1 294 ? 12.967  51.497  -26.259 1.00 55.18  ? 294 ILE B CG2 1 
ATOM   6226  C CD1 . ILE B 1 294 ? 11.324  49.097  -24.913 1.00 53.69  ? 294 ILE B CD1 1 
ATOM   6227  N N   . GLU B 1 295 ? 11.215  53.329  -28.486 1.00 53.32  ? 295 GLU B N   1 
ATOM   6228  C CA  . GLU B 1 295 ? 11.788  54.055  -29.608 1.00 53.92  ? 295 GLU B CA  1 
ATOM   6229  C C   . GLU B 1 295 ? 11.354  55.524  -29.560 1.00 50.04  ? 295 GLU B C   1 
ATOM   6230  O O   . GLU B 1 295 ? 12.187  56.429  -29.698 1.00 41.56  ? 295 GLU B O   1 
ATOM   6231  C CB  . GLU B 1 295 ? 11.344  53.271  -30.847 1.00 52.42  ? 295 GLU B CB  1 
ATOM   6232  C CG  . GLU B 1 295 ? 11.790  53.891  -32.161 1.00 55.98  ? 295 GLU B CG  1 
ATOM   6233  C CD  . GLU B 1 295 ? 10.792  54.831  -32.806 1.00 52.32  ? 295 GLU B CD  1 
ATOM   6234  O OE1 . GLU B 1 295 ? 9.614   54.925  -32.356 1.00 46.99  ? 295 GLU B OE1 1 
ATOM   6235  O OE2 . GLU B 1 295 ? 11.229  55.473  -33.797 1.00 64.16  ? 295 GLU B OE2 1 
ATOM   6236  N N   . THR B 1 296 ? 10.039  55.708  -29.359 1.00 43.88  ? 296 THR B N   1 
ATOM   6237  C CA  . THR B 1 296 ? 9.367   56.995  -29.337 1.00 50.51  ? 296 THR B CA  1 
ATOM   6238  C C   . THR B 1 296 ? 9.922   57.820  -28.186 1.00 48.63  ? 296 THR B C   1 
ATOM   6239  O O   . THR B 1 296 ? 10.260  58.974  -28.367 1.00 45.93  ? 296 THR B O   1 
ATOM   6240  C CB  . THR B 1 296 ? 7.854   56.801  -29.179 1.00 54.47  ? 296 THR B CB  1 
ATOM   6241  O OG1 . THR B 1 296 ? 7.336   56.358  -30.432 1.00 51.37  ? 296 THR B OG1 1 
ATOM   6242  C CG2 . THR B 1 296 ? 7.143   58.073  -28.744 1.00 57.29  ? 296 THR B CG2 1 
ATOM   6243  N N   . GLN B 1 297 ? 10.007  57.201  -27.010 1.00 53.23  ? 297 GLN B N   1 
ATOM   6244  C CA  . GLN B 1 297 ? 10.482  57.881  -25.818 1.00 53.09  ? 297 GLN B CA  1 
ATOM   6245  C C   . GLN B 1 297 ? 11.886  58.403  -26.090 1.00 49.05  ? 297 GLN B C   1 
ATOM   6246  O O   . GLN B 1 297 ? 12.229  59.529  -25.719 1.00 42.10  ? 297 GLN B O   1 
ATOM   6247  C CB  . GLN B 1 297 ? 10.397  56.958  -24.603 1.00 50.97  ? 297 GLN B CB  1 
ATOM   6248  C CG  . GLN B 1 297 ? 10.287  57.682  -23.261 1.00 51.57  ? 297 GLN B CG  1 
ATOM   6249  C CD  . GLN B 1 297 ? 11.625  58.159  -22.740 1.00 51.01  ? 297 GLN B CD  1 
ATOM   6250  O OE1 . GLN B 1 297 ? 12.645  57.480  -22.889 1.00 54.44  ? 297 GLN B OE1 1 
ATOM   6251  N NE2 . GLN B 1 297 ? 11.651  59.358  -22.177 1.00 56.07  ? 297 GLN B NE2 1 
ATOM   6252  N N   . ILE B 1 298 ? 12.692  57.598  -26.779 1.00 50.95  ? 298 ILE B N   1 
ATOM   6253  C CA  . ILE B 1 298 ? 14.017  58.069  -27.161 1.00 56.33  ? 298 ILE B CA  1 
ATOM   6254  C C   . ILE B 1 298 ? 13.880  59.298  -28.063 1.00 58.11  ? 298 ILE B C   1 
ATOM   6255  O O   . ILE B 1 298 ? 14.630  60.256  -27.879 1.00 50.97  ? 298 ILE B O   1 
ATOM   6256  C CB  . ILE B 1 298 ? 14.860  56.951  -27.800 1.00 55.46  ? 298 ILE B CB  1 
ATOM   6257  C CG1 . ILE B 1 298 ? 15.244  55.886  -26.760 1.00 61.07  ? 298 ILE B CG1 1 
ATOM   6258  C CG2 . ILE B 1 298 ? 16.097  57.516  -28.489 1.00 55.07  ? 298 ILE B CG2 1 
ATOM   6259  C CD1 . ILE B 1 298 ? 15.508  54.510  -27.354 1.00 61.84  ? 298 ILE B CD1 1 
ATOM   6260  N N   . ARG B 1 299 ? 12.926  59.262  -29.014 1.00 50.75  ? 299 ARG B N   1 
ATOM   6261  C CA  . ARG B 1 299 ? 12.717  60.368  -29.935 1.00 53.65  ? 299 ARG B CA  1 
ATOM   6262  C C   . ARG B 1 299 ? 12.281  61.651  -29.210 1.00 54.92  ? 299 ARG B C   1 
ATOM   6263  O O   . ARG B 1 299 ? 12.690  62.749  -29.600 1.00 51.64  ? 299 ARG B O   1 
ATOM   6264  C CB  . ARG B 1 299 ? 11.655  60.042  -30.984 1.00 53.32  ? 299 ARG B CB  1 
ATOM   6265  C CG  . ARG B 1 299 ? 11.426  61.188  -31.956 1.00 54.95  ? 299 ARG B CG  1 
ATOM   6266  C CD  . ARG B 1 299 ? 10.705  60.729  -33.201 1.00 55.26  ? 299 ARG B CD  1 
ATOM   6267  N NE  . ARG B 1 299 ? 9.379   60.233  -32.818 1.00 63.11  ? 299 ARG B NE  1 
ATOM   6268  C CZ  . ARG B 1 299 ? 9.015   58.956  -32.647 1.00 61.68  ? 299 ARG B CZ  1 
ATOM   6269  N NH1 . ARG B 1 299 ? 9.889   57.979  -32.807 1.00 54.82  ? 299 ARG B NH1 1 
ATOM   6270  N NH2 . ARG B 1 299 ? 7.769   58.667  -32.299 1.00 61.41  ? 299 ARG B NH2 1 
ATOM   6271  N N   . HIS B 1 300 ? 11.413  61.515  -28.197 1.00 51.86  ? 300 HIS B N   1 
ATOM   6272  C CA  . HIS B 1 300 ? 10.933  62.637  -27.398 1.00 50.77  ? 300 HIS B CA  1 
ATOM   6273  C C   . HIS B 1 300 ? 12.106  63.469  -26.875 1.00 54.21  ? 300 HIS B C   1 
ATOM   6274  O O   . HIS B 1 300 ? 12.125  64.703  -26.958 1.00 45.83  ? 300 HIS B O   1 
ATOM   6275  C CB  . HIS B 1 300 ? 10.114  62.097  -26.228 1.00 49.36  ? 300 HIS B CB  1 
ATOM   6276  C CG  . HIS B 1 300 ? 8.777   61.604  -26.627 1.00 48.95  ? 300 HIS B CG  1 
ATOM   6277  N ND1 . HIS B 1 300 ? 7.972   60.911  -25.747 1.00 50.85  ? 300 HIS B ND1 1 
ATOM   6278  C CD2 . HIS B 1 300 ? 8.059   61.764  -27.755 1.00 46.50  ? 300 HIS B CD2 1 
ATOM   6279  C CE1 . HIS B 1 300 ? 6.812   60.648  -26.337 1.00 46.68  ? 300 HIS B CE1 1 
ATOM   6280  N NE2 . HIS B 1 300 ? 6.847   61.142  -27.558 1.00 52.11  ? 300 HIS B NE2 1 
ATOM   6281  N N   . ALA B 1 301 ? 13.110  62.764  -26.353 1.00 46.33  ? 301 ALA B N   1 
ATOM   6282  C CA  . ALA B 1 301 ? 14.234  63.432  -25.734 1.00 52.62  ? 301 ALA B CA  1 
ATOM   6283  C C   . ALA B 1 301 ? 15.010  64.231  -26.776 1.00 54.41  ? 301 ALA B C   1 
ATOM   6284  O O   . ALA B 1 301 ? 15.497  65.323  -26.485 1.00 60.41  ? 301 ALA B O   1 
ATOM   6285  C CB  . ALA B 1 301 ? 15.116  62.423  -25.038 1.00 53.25  ? 301 ALA B CB  1 
ATOM   6286  N N   . VAL B 1 302 ? 15.159  63.655  -27.975 1.00 55.71  ? 302 VAL B N   1 
ATOM   6287  C CA  . VAL B 1 302 ? 15.978  64.253  -29.023 1.00 53.95  ? 302 VAL B CA  1 
ATOM   6288  C C   . VAL B 1 302 ? 15.265  65.520  -29.502 1.00 43.58  ? 302 VAL B C   1 
ATOM   6289  O O   . VAL B 1 302 ? 15.878  66.552  -29.734 1.00 40.93  ? 302 VAL B O   1 
ATOM   6290  C CB  . VAL B 1 302 ? 16.244  63.262  -30.185 1.00 59.90  ? 302 VAL B CB  1 
ATOM   6291  C CG1 . VAL B 1 302 ? 17.171  63.852  -31.245 1.00 56.64  ? 302 VAL B CG1 1 
ATOM   6292  C CG2 . VAL B 1 302 ? 16.796  61.919  -29.708 1.00 57.03  ? 302 VAL B CG2 1 
ATOM   6293  N N   . HIS B 1 303 ? 13.945  65.424  -29.612 1.00 43.01  ? 303 HIS B N   1 
ATOM   6294  C CA  . HIS B 1 303 ? 13.133  66.526  -30.068 1.00 49.54  ? 303 HIS B CA  1 
ATOM   6295  C C   . HIS B 1 303 ? 13.317  67.670  -29.067 1.00 50.60  ? 303 HIS B C   1 
ATOM   6296  O O   . HIS B 1 303 ? 13.625  68.796  -29.472 1.00 44.81  ? 303 HIS B O   1 
ATOM   6297  C CB  . HIS B 1 303 ? 11.695  66.047  -30.333 1.00 47.62  ? 303 HIS B CB  1 
ATOM   6298  C CG  . HIS B 1 303 ? 10.811  67.110  -30.897 1.00 49.01  ? 303 HIS B CG  1 
ATOM   6299  N ND1 . HIS B 1 303 ? 9.485   67.259  -30.553 1.00 50.39  ? 303 HIS B ND1 1 
ATOM   6300  C CD2 . HIS B 1 303 ? 11.097  68.125  -31.750 1.00 51.91  ? 303 HIS B CD2 1 
ATOM   6301  C CE1 . HIS B 1 303 ? 8.987   68.316  -31.197 1.00 56.44  ? 303 HIS B CE1 1 
ATOM   6302  N NE2 . HIS B 1 303 ? 9.953   68.848  -31.934 1.00 52.79  ? 303 HIS B NE2 1 
ATOM   6303  N N   . ALA B 1 304 ? 13.174  67.365  -27.765 1.00 54.72  ? 304 ALA B N   1 
ATOM   6304  C CA  . ALA B 1 304 ? 13.370  68.353  -26.703 1.00 50.55  ? 304 ALA B CA  1 
ATOM   6305  C C   . ALA B 1 304 ? 14.777  68.943  -26.802 1.00 49.12  ? 304 ALA B C   1 
ATOM   6306  O O   . ALA B 1 304 ? 14.961  70.144  -26.605 1.00 44.98  ? 304 ALA B O   1 
ATOM   6307  C CB  . ALA B 1 304 ? 13.101  67.753  -25.332 1.00 51.48  ? 304 ALA B CB  1 
ATOM   6308  N N   . GLU B 1 305 ? 15.750  68.118  -27.200 1.00 45.00  ? 305 GLU B N   1 
ATOM   6309  C CA  . GLU B 1 305 ? 17.096  68.622  -27.438 1.00 49.58  ? 305 GLU B CA  1 
ATOM   6310  C C   . GLU B 1 305 ? 17.064  69.648  -28.578 1.00 50.14  ? 305 GLU B C   1 
ATOM   6311  O O   . GLU B 1 305 ? 17.663  70.727  -28.500 1.00 44.41  ? 305 GLU B O   1 
ATOM   6312  C CB  . GLU B 1 305 ? 18.046  67.435  -27.614 1.00 49.52  ? 305 GLU B CB  1 
ATOM   6313  C CG  . GLU B 1 305 ? 19.473  67.806  -28.011 1.00 54.32  ? 305 GLU B CG  1 
ATOM   6314  C CD  . GLU B 1 305 ? 20.395  66.602  -28.148 1.00 55.28  ? 305 GLU B CD  1 
ATOM   6315  O OE1 . GLU B 1 305 ? 19.999  65.502  -27.729 1.00 64.38  ? 305 GLU B OE1 1 
ATOM   6316  O OE2 . GLU B 1 305 ? 21.501  66.747  -28.679 1.00 53.47  ? 305 GLU B OE2 1 
ATOM   6317  N N   . LEU B 1 306 ? 16.364  69.317  -29.659 1.00 45.10  ? 306 LEU B N   1 
ATOM   6318  C CA  . LEU B 1 306 ? 16.344  70.212  -30.796 1.00 45.63  ? 306 LEU B CA  1 
ATOM   6319  C C   . LEU B 1 306 ? 15.709  71.537  -30.377 1.00 46.37  ? 306 LEU B C   1 
ATOM   6320  O O   . LEU B 1 306 ? 16.203  72.598  -30.730 1.00 48.58  ? 306 LEU B O   1 
ATOM   6321  C CB  . LEU B 1 306 ? 15.596  69.569  -31.957 1.00 49.11  ? 306 LEU B CB  1 
ATOM   6322  C CG  . LEU B 1 306 ? 15.381  70.472  -33.172 1.00 57.33  ? 306 LEU B CG  1 
ATOM   6323  C CD1 . LEU B 1 306 ? 16.694  70.786  -33.880 1.00 58.97  ? 306 LEU B CD1 1 
ATOM   6324  C CD2 . LEU B 1 306 ? 14.385  69.818  -34.102 1.00 66.34  ? 306 LEU B CD2 1 
ATOM   6325  N N   . ILE B 1 307 ? 14.619  71.459  -29.614 1.00 44.15  ? 307 ILE B N   1 
ATOM   6326  C CA  . ILE B 1 307 ? 13.846  72.624  -29.225 1.00 47.70  ? 307 ILE B CA  1 
ATOM   6327  C C   . ILE B 1 307 ? 14.719  73.561  -28.397 1.00 48.13  ? 307 ILE B C   1 
ATOM   6328  O O   . ILE B 1 307 ? 14.776  74.757  -28.663 1.00 54.25  ? 307 ILE B O   1 
ATOM   6329  C CB  . ILE B 1 307 ? 12.563  72.183  -28.486 1.00 51.92  ? 307 ILE B CB  1 
ATOM   6330  C CG1 . ILE B 1 307 ? 11.487  71.684  -29.490 1.00 54.03  ? 307 ILE B CG1 1 
ATOM   6331  C CG2 . ILE B 1 307 ? 12.035  73.287  -27.566 1.00 49.69  ? 307 ILE B CG2 1 
ATOM   6332  C CD1 . ILE B 1 307 ? 10.431  70.750  -28.914 1.00 57.10  ? 307 ILE B CD1 1 
ATOM   6333  N N   . VAL B 1 308 ? 15.408  73.015  -27.401 1.00 52.58  ? 308 VAL B N   1 
ATOM   6334  C CA  . VAL B 1 308 ? 16.187  73.839  -26.491 1.00 55.01  ? 308 VAL B CA  1 
ATOM   6335  C C   . VAL B 1 308 ? 17.369  74.432  -27.247 1.00 45.95  ? 308 VAL B C   1 
ATOM   6336  O O   . VAL B 1 308 ? 17.721  75.586  -27.017 1.00 47.82  ? 308 VAL B O   1 
ATOM   6337  C CB  . VAL B 1 308 ? 16.656  73.124  -25.209 1.00 60.64  ? 308 VAL B CB  1 
ATOM   6338  C CG1 . VAL B 1 308 ? 17.620  71.979  -25.486 1.00 58.29  ? 308 VAL B CG1 1 
ATOM   6339  C CG2 . VAL B 1 308 ? 17.270  74.120  -24.231 1.00 74.68  ? 308 VAL B CG2 1 
ATOM   6340  N N   . GLY B 1 309 ? 17.952  73.655  -28.167 1.00 48.94  ? 309 GLY B N   1 
ATOM   6341  C CA  . GLY B 1 309 ? 19.028  74.137  -29.031 1.00 48.81  ? 309 GLY B CA  1 
ATOM   6342  C C   . GLY B 1 309 ? 18.578  75.306  -29.908 1.00 52.33  ? 309 GLY B C   1 
ATOM   6343  O O   . GLY B 1 309 ? 19.229  76.353  -29.931 1.00 53.63  ? 309 GLY B O   1 
ATOM   6344  N N   . LEU B 1 310 ? 17.427  75.137  -30.584 1.00 49.44  ? 310 LEU B N   1 
ATOM   6345  C CA  . LEU B 1 310 ? 16.823  76.201  -31.371 1.00 50.71  ? 310 LEU B CA  1 
ATOM   6346  C C   . LEU B 1 310 ? 16.575  77.447  -30.514 1.00 53.78  ? 310 LEU B C   1 
ATOM   6347  O O   . LEU B 1 310 ? 16.724  78.578  -30.977 1.00 52.35  ? 310 LEU B O   1 
ATOM   6348  C CB  . LEU B 1 310 ? 15.522  75.695  -31.993 1.00 51.69  ? 310 LEU B CB  1 
ATOM   6349  C CG  . LEU B 1 310 ? 15.656  74.775  -33.214 1.00 51.36  ? 310 LEU B CG  1 
ATOM   6350  C CD1 . LEU B 1 310 ? 14.265  74.295  -33.597 1.00 49.70  ? 310 LEU B CD1 1 
ATOM   6351  C CD2 . LEU B 1 310 ? 16.357  75.442  -34.383 1.00 43.76  ? 310 LEU B CD2 1 
ATOM   6352  N N   . ALA B 1 311 ? 16.137  77.245  -29.274 1.00 48.62  ? 311 ALA B N   1 
ATOM   6353  C CA  . ALA B 1 311 ? 15.750  78.362  -28.438 1.00 48.79  ? 311 ALA B CA  1 
ATOM   6354  C C   . ALA B 1 311 ? 17.005  79.110  -28.005 1.00 50.83  ? 311 ALA B C   1 
ATOM   6355  O O   . ALA B 1 311 ? 17.005  80.336  -27.924 1.00 45.24  ? 311 ALA B O   1 
ATOM   6356  C CB  . ALA B 1 311 ? 14.947  77.866  -27.261 1.00 51.96  ? 311 ALA B CB  1 
ATOM   6357  N N   . LEU B 1 312 ? 18.082  78.357  -27.763 1.00 51.34  ? 312 LEU B N   1 
ATOM   6358  C CA  . LEU B 1 312 ? 19.347  78.962  -27.385 1.00 55.48  ? 312 LEU B CA  1 
ATOM   6359  C C   . LEU B 1 312 ? 19.817  79.845  -28.532 1.00 53.24  ? 312 LEU B C   1 
ATOM   6360  O O   . LEU B 1 312 ? 20.262  80.956  -28.289 1.00 61.24  ? 312 LEU B O   1 
ATOM   6361  C CB  . LEU B 1 312 ? 20.432  77.950  -27.000 1.00 53.39  ? 312 LEU B CB  1 
ATOM   6362  C CG  . LEU B 1 312 ? 20.438  77.474  -25.545 1.00 57.69  ? 312 LEU B CG  1 
ATOM   6363  C CD1 . LEU B 1 312 ? 21.494  76.389  -25.296 1.00 56.32  ? 312 LEU B CD1 1 
ATOM   6364  C CD2 . LEU B 1 312 ? 20.662  78.652  -24.590 1.00 56.15  ? 312 LEU B CD2 1 
ATOM   6365  N N   . LEU B 1 313 ? 19.747  79.321  -29.760 1.00 55.54  ? 313 LEU B N   1 
ATOM   6366  C CA  . LEU B 1 313 ? 20.252  80.015  -30.941 1.00 59.89  ? 313 LEU B CA  1 
ATOM   6367  C C   . LEU B 1 313 ? 19.422  81.276  -31.192 1.00 58.92  ? 313 LEU B C   1 
ATOM   6368  O O   . LEU B 1 313 ? 19.965  82.344  -31.484 1.00 56.17  ? 313 LEU B O   1 
ATOM   6369  C CB  . LEU B 1 313 ? 20.227  79.086  -32.165 1.00 56.33  ? 313 LEU B CB  1 
ATOM   6370  C CG  . LEU B 1 313 ? 21.306  77.992  -32.232 1.00 58.33  ? 313 LEU B CG  1 
ATOM   6371  C CD1 . LEU B 1 313 ? 21.033  76.983  -33.365 1.00 55.13  ? 313 LEU B CD1 1 
ATOM   6372  C CD2 . LEU B 1 313 ? 22.693  78.624  -32.381 1.00 55.87  ? 313 LEU B CD2 1 
ATOM   6373  N N   . LEU B 1 314 ? 18.097  81.115  -31.083 1.00 55.74  ? 314 LEU B N   1 
ATOM   6374  C CA  . LEU B 1 314 ? 17.148  82.171  -31.374 1.00 53.30  ? 314 LEU B CA  1 
ATOM   6375  C C   . LEU B 1 314 ? 17.372  83.350  -30.430 1.00 51.29  ? 314 LEU B C   1 
ATOM   6376  O O   . LEU B 1 314 ? 17.431  84.486  -30.886 1.00 47.02  ? 314 LEU B O   1 
ATOM   6377  C CB  . LEU B 1 314 ? 15.732  81.614  -31.244 1.00 50.10  ? 314 LEU B CB  1 
ATOM   6378  C CG  . LEU B 1 314 ? 14.599  82.614  -31.475 1.00 52.40  ? 314 LEU B CG  1 
ATOM   6379  C CD1 . LEU B 1 314 ? 14.578  83.061  -32.919 1.00 57.11  ? 314 LEU B CD1 1 
ATOM   6380  C CD2 . LEU B 1 314 ? 13.277  82.008  -31.069 1.00 58.82  ? 314 LEU B CD2 1 
ATOM   6381  N N   . THR B 1 315 ? 17.461  83.067  -29.122 1.00 51.05  ? 315 THR B N   1 
ATOM   6382  C CA  . THR B 1 315 ? 17.491  84.110  -28.114 1.00 53.12  ? 315 THR B CA  1 
ATOM   6383  C C   . THR B 1 315 ? 18.860  84.788  -28.148 1.00 55.42  ? 315 THR B C   1 
ATOM   6384  O O   . THR B 1 315 ? 18.973  85.987  -27.874 1.00 58.84  ? 315 THR B O   1 
ATOM   6385  C CB  . THR B 1 315 ? 17.131  83.543  -26.740 1.00 52.98  ? 315 THR B CB  1 
ATOM   6386  O OG1 . THR B 1 315 ? 18.053  82.492  -26.484 1.00 49.67  ? 315 THR B OG1 1 
ATOM   6387  C CG2 . THR B 1 315 ? 15.701  83.025  -26.677 1.00 53.57  ? 315 THR B CG2 1 
ATOM   6388  N N   . ASN B 1 316 ? 19.887  84.030  -28.538 1.00 50.56  ? 316 ASN B N   1 
ATOM   6389  C CA  . ASN B 1 316 ? 21.199  84.607  -28.740 1.00 60.03  ? 316 ASN B CA  1 
ATOM   6390  C C   . ASN B 1 316 ? 21.162  85.509  -29.975 1.00 62.94  ? 316 ASN B C   1 
ATOM   6391  O O   . ASN B 1 316 ? 21.730  86.601  -29.966 1.00 66.02  ? 316 ASN B O   1 
ATOM   6392  C CB  . ASN B 1 316 ? 22.287  83.549  -28.834 1.00 65.99  ? 316 ASN B CB  1 
ATOM   6393  C CG  . ASN B 1 316 ? 23.661  84.180  -28.855 1.00 71.80  ? 316 ASN B CG  1 
ATOM   6394  O OD1 . ASN B 1 316 ? 24.191  84.547  -27.798 1.00 70.31  ? 316 ASN B OD1 1 
ATOM   6395  N ND2 . ASN B 1 316 ? 24.250  84.309  -30.036 1.00 68.48  ? 316 ASN B ND2 1 
ATOM   6396  N N   . ALA B 1 317 ? 20.471  85.055  -31.026 1.00 55.53  ? 317 ALA B N   1 
ATOM   6397  C CA  . ALA B 1 317 ? 20.397  85.811  -32.269 1.00 60.31  ? 317 ALA B CA  1 
ATOM   6398  C C   . ALA B 1 317 ? 19.620  87.124  -32.077 1.00 59.11  ? 317 ALA B C   1 
ATOM   6399  O O   . ALA B 1 317 ? 19.897  88.108  -32.752 1.00 62.78  ? 317 ALA B O   1 
ATOM   6400  C CB  . ALA B 1 317 ? 19.799  84.939  -33.366 1.00 53.25  ? 317 ALA B CB  1 
ATOM   6401  N N   . LEU B 1 318 ? 18.645  87.132  -31.158 1.00 61.72  ? 318 LEU B N   1 
ATOM   6402  C CA  . LEU B 1 318 ? 17.797  88.289  -30.913 1.00 60.39  ? 318 LEU B CA  1 
ATOM   6403  C C   . LEU B 1 318 ? 18.349  89.145  -29.762 1.00 63.02  ? 318 LEU B C   1 
ATOM   6404  O O   . LEU B 1 318 ? 17.830  90.229  -29.519 1.00 65.98  ? 318 LEU B O   1 
ATOM   6405  C CB  . LEU B 1 318 ? 16.354  87.853  -30.619 1.00 60.98  ? 318 LEU B CB  1 
ATOM   6406  C CG  . LEU B 1 318 ? 15.514  87.312  -31.786 1.00 59.52  ? 318 LEU B CG  1 
ATOM   6407  C CD1 . LEU B 1 318 ? 14.297  86.563  -31.254 1.00 57.67  ? 318 LEU B CD1 1 
ATOM   6408  C CD2 . LEU B 1 318 ? 15.065  88.391  -32.769 1.00 60.58  ? 318 LEU B CD2 1 
ATOM   6409  N N   . GLY B 1 319 ? 19.355  88.663  -29.016 1.00 62.07  ? 319 GLY B N   1 
ATOM   6410  C CA  . GLY B 1 319 ? 19.946  89.426  -27.920 1.00 59.22  ? 319 GLY B CA  1 
ATOM   6411  C C   . GLY B 1 319 ? 19.126  89.411  -26.619 1.00 67.29  ? 319 GLY B C   1 
ATOM   6412  O O   . GLY B 1 319 ? 19.327  90.276  -25.754 1.00 63.11  ? 319 GLY B O   1 
ATOM   6413  N N   . THR B 1 320 ? 18.261  88.392  -26.443 1.00 63.42  ? 320 THR B N   1 
ATOM   6414  C CA  . THR B 1 320 ? 17.298  88.349  -25.345 1.00 61.46  ? 320 THR B CA  1 
ATOM   6415  C C   . THR B 1 320 ? 17.708  87.341  -24.262 1.00 62.97  ? 320 THR B C   1 
ATOM   6416  O O   . THR B 1 320 ? 17.011  87.225  -23.251 1.00 59.43  ? 320 THR B O   1 
ATOM   6417  C CB  . THR B 1 320 ? 15.909  88.008  -25.903 1.00 63.83  ? 320 THR B CB  1 
ATOM   6418  O OG1 . THR B 1 320 ? 15.956  86.725  -26.545 1.00 60.21  ? 320 THR B OG1 1 
ATOM   6419  C CG2 . THR B 1 320 ? 15.395  89.071  -26.862 1.00 58.72  ? 320 THR B CG2 1 
ATOM   6420  N N   . ASN B 1 321 ? 18.826  86.617  -24.462 1.00 67.68  ? 321 ASN B N   1 
ATOM   6421  C CA  . ASN B 1 321 ? 19.176  85.457  -23.640 1.00 75.69  ? 321 ASN B CA  1 
ATOM   6422  C C   . ASN B 1 321 ? 19.827  85.853  -22.307 1.00 76.17  ? 321 ASN B C   1 
ATOM   6423  O O   . ASN B 1 321 ? 20.039  84.986  -21.461 1.00 81.31  ? 321 ASN B O   1 
ATOM   6424  C CB  . ASN B 1 321 ? 20.027  84.451  -24.418 1.00 73.93  ? 321 ASN B CB  1 
ATOM   6425  C CG  . ASN B 1 321 ? 21.392  84.971  -24.809 1.00 81.83  ? 321 ASN B CG  1 
ATOM   6426  O OD1 . ASN B 1 321 ? 21.507  86.071  -25.369 1.00 87.55  ? 321 ASN B OD1 1 
ATOM   6427  N ND2 . ASN B 1 321 ? 22.433  84.188  -24.548 1.00 85.65  ? 321 ASN B ND2 1 
ATOM   6428  N N   . ASN B 1 322 ? 20.114  87.151  -22.119 1.00 82.39  ? 322 ASN B N   1 
ATOM   6429  C CA  . ASN B 1 322 ? 20.572  87.704  -20.848 1.00 90.12  ? 322 ASN B CA  1 
ATOM   6430  C C   . ASN B 1 322 ? 19.410  88.265  -20.009 1.00 72.38  ? 322 ASN B C   1 
ATOM   6431  O O   . ASN B 1 322 ? 19.614  88.537  -18.827 1.00 69.96  ? 322 ASN B O   1 
ATOM   6432  C CB  . ASN B 1 322 ? 21.651  88.765  -21.062 1.00 105.98 ? 322 ASN B CB  1 
ATOM   6433  C CG  . ASN B 1 322 ? 21.125  89.970  -21.817 1.00 121.34 ? 322 ASN B CG  1 
ATOM   6434  O OD1 . ASN B 1 322 ? 20.769  89.854  -22.998 1.00 128.55 ? 322 ASN B OD1 1 
ATOM   6435  N ND2 . ASN B 1 322 ? 21.051  91.124  -21.164 1.00 109.93 ? 322 ASN B ND2 1 
ATOM   6436  N N   . ASN B 1 323 ? 18.206  88.448  -20.593 1.00 59.58  ? 323 ASN B N   1 
ATOM   6437  C CA  . ASN B 1 323 ? 16.999  88.752  -19.824 1.00 64.48  ? 323 ASN B CA  1 
ATOM   6438  C C   . ASN B 1 323 ? 16.784  87.653  -18.771 1.00 62.37  ? 323 ASN B C   1 
ATOM   6439  O O   . ASN B 1 323 ? 16.749  86.471  -19.105 1.00 56.61  ? 323 ASN B O   1 
ATOM   6440  C CB  . ASN B 1 323 ? 15.782  88.927  -20.741 1.00 69.88  ? 323 ASN B CB  1 
ATOM   6441  C CG  . ASN B 1 323 ? 14.491  89.268  -20.011 1.00 82.48  ? 323 ASN B CG  1 
ATOM   6442  O OD1 . ASN B 1 323 ? 14.151  88.654  -18.992 1.00 77.10  ? 323 ASN B OD1 1 
ATOM   6443  N ND2 . ASN B 1 323 ? 13.726  90.232  -20.514 1.00 81.65  ? 323 ASN B ND2 1 
ATOM   6444  N N   . PRO B 1 324 ? 16.669  87.974  -17.459 1.00 62.40  ? 324 PRO B N   1 
ATOM   6445  C CA  . PRO B 1 324 ? 16.338  86.965  -16.435 1.00 66.45  ? 324 PRO B CA  1 
ATOM   6446  C C   . PRO B 1 324 ? 15.109  86.063  -16.633 1.00 62.06  ? 324 PRO B C   1 
ATOM   6447  O O   . PRO B 1 324 ? 15.082  84.930  -16.147 1.00 58.55  ? 324 PRO B O   1 
ATOM   6448  C CB  . PRO B 1 324 ? 16.158  87.855  -15.176 1.00 64.88  ? 324 PRO B CB  1 
ATOM   6449  C CG  . PRO B 1 324 ? 17.089  89.021  -15.415 1.00 61.55  ? 324 PRO B CG  1 
ATOM   6450  C CD  . PRO B 1 324 ? 16.903  89.311  -16.888 1.00 63.22  ? 324 PRO B CD  1 
ATOM   6451  N N   . ILE B 1 325 ? 14.068  86.576  -17.303 1.00 53.67  ? 325 ILE B N   1 
ATOM   6452  C CA  . ILE B 1 325 ? 12.852  85.813  -17.529 1.00 56.92  ? 325 ILE B CA  1 
ATOM   6453  C C   . ILE B 1 325 ? 13.134  84.776  -18.614 1.00 59.60  ? 325 ILE B C   1 
ATOM   6454  O O   . ILE B 1 325 ? 12.801  83.600  -18.454 1.00 56.87  ? 325 ILE B O   1 
ATOM   6455  C CB  . ILE B 1 325 ? 11.670  86.743  -17.868 1.00 58.26  ? 325 ILE B CB  1 
ATOM   6456  C CG1 . ILE B 1 325 ? 11.292  87.598  -16.652 1.00 61.09  ? 325 ILE B CG1 1 
ATOM   6457  C CG2 . ILE B 1 325 ? 10.463  85.966  -18.392 1.00 54.80  ? 325 ILE B CG2 1 
ATOM   6458  C CD1 . ILE B 1 325 ? 10.401  88.778  -16.979 1.00 57.76  ? 325 ILE B CD1 1 
ATOM   6459  N N   . VAL B 1 326 ? 13.793  85.224  -19.687 1.00 58.35  ? 326 VAL B N   1 
ATOM   6460  C CA  . VAL B 1 326 ? 14.142  84.372  -20.815 1.00 60.96  ? 326 VAL B CA  1 
ATOM   6461  C C   . VAL B 1 326 ? 15.060  83.235  -20.370 1.00 55.58  ? 326 VAL B C   1 
ATOM   6462  O O   . VAL B 1 326 ? 14.866  82.092  -20.752 1.00 61.85  ? 326 VAL B O   1 
ATOM   6463  C CB  . VAL B 1 326 ? 14.787  85.237  -21.914 1.00 54.13  ? 326 VAL B CB  1 
ATOM   6464  C CG1 . VAL B 1 326 ? 15.510  84.396  -22.956 1.00 54.17  ? 326 VAL B CG1 1 
ATOM   6465  C CG2 . VAL B 1 326 ? 13.736  86.134  -22.551 1.00 55.89  ? 326 VAL B CG2 1 
ATOM   6466  N N   . GLN B 1 327 ? 16.070  83.571  -19.577 1.00 57.89  ? 327 GLN B N   1 
ATOM   6467  C CA  . GLN B 1 327 ? 17.009  82.605  -19.027 1.00 63.59  ? 327 GLN B CA  1 
ATOM   6468  C C   . GLN B 1 327 ? 16.273  81.524  -18.223 1.00 64.09  ? 327 GLN B C   1 
ATOM   6469  O O   . GLN B 1 327 ? 16.595  80.320  -18.292 1.00 52.16  ? 327 GLN B O   1 
ATOM   6470  C CB  . GLN B 1 327 ? 18.034  83.428  -18.239 1.00 57.43  ? 327 GLN B CB  1 
ATOM   6471  C CG  . GLN B 1 327 ? 18.934  82.600  -17.338 1.00 72.47  ? 327 GLN B CG  1 
ATOM   6472  C CD  . GLN B 1 327 ? 20.397  82.931  -17.500 1.00 85.77  ? 327 GLN B CD  1 
ATOM   6473  O OE1 . GLN B 1 327 ? 20.827  83.409  -18.557 1.00 99.43  ? 327 GLN B OE1 1 
ATOM   6474  N NE2 . GLN B 1 327 ? 21.174  82.626  -16.467 1.00 83.44  ? 327 GLN B NE2 1 
ATOM   6475  N N   . SER B 1 328 ? 15.293  81.982  -17.437 1.00 57.58  ? 328 SER B N   1 
ATOM   6476  C CA  . SER B 1 328 ? 14.537  81.103  -16.565 1.00 61.40  ? 328 SER B CA  1 
ATOM   6477  C C   . SER B 1 328 ? 13.733  80.114  -17.411 1.00 56.00  ? 328 SER B C   1 
ATOM   6478  O O   . SER B 1 328 ? 13.699  78.923  -17.108 1.00 55.24  ? 328 SER B O   1 
ATOM   6479  C CB  . SER B 1 328 ? 13.671  81.920  -15.626 1.00 64.16  ? 328 SER B CB  1 
ATOM   6480  O OG  . SER B 1 328 ? 13.042  81.104  -14.644 1.00 79.19  ? 328 SER B OG  1 
ATOM   6481  N N   . GLN B 1 329 ? 13.079  80.620  -18.467 1.00 53.34  ? 329 GLN B N   1 
ATOM   6482  C CA  . GLN B 1 329 ? 12.259  79.797  -19.344 1.00 51.40  ? 329 GLN B CA  1 
ATOM   6483  C C   . GLN B 1 329 ? 13.134  78.793  -20.093 1.00 54.49  ? 329 GLN B C   1 
ATOM   6484  O O   . GLN B 1 329 ? 12.697  77.658  -20.315 1.00 50.20  ? 329 GLN B O   1 
ATOM   6485  C CB  . GLN B 1 329 ? 11.495  80.675  -20.329 1.00 50.91  ? 329 GLN B CB  1 
ATOM   6486  C CG  . GLN B 1 329 ? 10.365  81.483  -19.693 1.00 55.55  ? 329 GLN B CG  1 
ATOM   6487  C CD  . GLN B 1 329 ? 10.046  82.783  -20.415 1.00 50.96  ? 329 GLN B CD  1 
ATOM   6488  O OE1 . GLN B 1 329 ? 10.871  83.368  -21.131 1.00 51.93  ? 329 GLN B OE1 1 
ATOM   6489  N NE2 . GLN B 1 329 ? 8.831   83.263  -20.215 1.00 48.19  ? 329 GLN B NE2 1 
ATOM   6490  N N   . LEU B 1 330 ? 14.351  79.239  -20.472 1.00 52.56  ? 330 LEU B N   1 
ATOM   6491  C CA  . LEU B 1 330 ? 15.350  78.420  -21.153 1.00 50.21  ? 330 LEU B CA  1 
ATOM   6492  C C   . LEU B 1 330 ? 15.744  77.260  -20.251 1.00 46.75  ? 330 LEU B C   1 
ATOM   6493  O O   . LEU B 1 330 ? 15.776  76.111  -20.696 1.00 42.67  ? 330 LEU B O   1 
ATOM   6494  C CB  . LEU B 1 330 ? 16.594  79.212  -21.555 1.00 50.86  ? 330 LEU B CB  1 
ATOM   6495  C CG  . LEU B 1 330 ? 16.455  80.118  -22.783 1.00 52.34  ? 330 LEU B CG  1 
ATOM   6496  C CD1 . LEU B 1 330 ? 17.595  81.116  -22.808 1.00 55.91  ? 330 LEU B CD1 1 
ATOM   6497  C CD2 . LEU B 1 330 ? 16.430  79.316  -24.080 1.00 48.09  ? 330 LEU B CD2 1 
ATOM   6498  N N   . ALA B 1 331 ? 16.033  77.584  -18.982 1.00 44.83  ? 331 ALA B N   1 
ATOM   6499  C CA  . ALA B 1 331 ? 16.344  76.561  -17.996 1.00 47.70  ? 331 ALA B CA  1 
ATOM   6500  C C   . ALA B 1 331 ? 15.229  75.506  -17.895 1.00 46.73  ? 331 ALA B C   1 
ATOM   6501  O O   . ALA B 1 331 ? 15.522  74.332  -17.740 1.00 44.50  ? 331 ALA B O   1 
ATOM   6502  C CB  . ALA B 1 331 ? 16.625  77.213  -16.679 1.00 48.73  ? 331 ALA B CB  1 
ATOM   6503  N N   . ASP B 1 332 ? 13.952  75.903  -18.014 1.00 49.69  ? 332 ASP B N   1 
ATOM   6504  C CA  . ASP B 1 332 ? 12.837  74.966  -17.948 1.00 50.45  ? 332 ASP B CA  1 
ATOM   6505  C C   . ASP B 1 332 ? 12.799  74.090  -19.205 1.00 56.64  ? 332 ASP B C   1 
ATOM   6506  O O   . ASP B 1 332 ? 12.427  72.916  -19.119 1.00 49.33  ? 332 ASP B O   1 
ATOM   6507  C CB  . ASP B 1 332 ? 11.509  75.663  -17.663 1.00 58.40  ? 332 ASP B CB  1 
ATOM   6508  C CG  . ASP B 1 332 ? 11.211  75.999  -16.201 1.00 62.81  ? 332 ASP B CG  1 
ATOM   6509  O OD1 . ASP B 1 332 ? 12.087  75.757  -15.308 1.00 53.05  ? 332 ASP B OD1 1 
ATOM   6510  O OD2 . ASP B 1 332 ? 10.103  76.503  -15.960 1.00 59.21  ? 332 ASP B OD2 1 
ATOM   6511  N N   . LEU B 1 333 ? 13.223  74.637  -20.361 1.00 55.83  ? 333 LEU B N   1 
ATOM   6512  C CA  . LEU B 1 333 ? 13.356  73.832  -21.572 1.00 54.63  ? 333 LEU B CA  1 
ATOM   6513  C C   . LEU B 1 333 ? 14.495  72.821  -21.434 1.00 48.97  ? 333 LEU B C   1 
ATOM   6514  O O   . LEU B 1 333 ? 14.366  71.676  -21.861 1.00 44.62  ? 333 LEU B O   1 
ATOM   6515  C CB  . LEU B 1 333 ? 13.561  74.709  -22.801 1.00 52.33  ? 333 LEU B CB  1 
ATOM   6516  C CG  . LEU B 1 333 ? 12.358  75.553  -23.205 1.00 51.19  ? 333 LEU B CG  1 
ATOM   6517  C CD1 . LEU B 1 333 ? 12.721  76.312  -24.465 1.00 59.08  ? 333 LEU B CD1 1 
ATOM   6518  C CD2 . LEU B 1 333 ? 11.121  74.696  -23.396 1.00 48.21  ? 333 LEU B CD2 1 
ATOM   6519  N N   . VAL B 1 334 ? 15.596  73.253  -20.818 1.00 48.34  ? 334 VAL B N   1 
ATOM   6520  C CA  . VAL B 1 334 ? 16.683  72.346  -20.511 1.00 51.37  ? 334 VAL B CA  1 
ATOM   6521  C C   . VAL B 1 334 ? 16.120  71.228  -19.637 1.00 53.04  ? 334 VAL B C   1 
ATOM   6522  O O   . VAL B 1 334 ? 16.380  70.053  -19.887 1.00 51.37  ? 334 VAL B O   1 
ATOM   6523  C CB  . VAL B 1 334 ? 17.868  73.058  -19.828 1.00 53.05  ? 334 VAL B CB  1 
ATOM   6524  C CG1 . VAL B 1 334 ? 18.953  72.081  -19.362 1.00 55.29  ? 334 VAL B CG1 1 
ATOM   6525  C CG2 . VAL B 1 334 ? 18.476  74.137  -20.719 1.00 48.88  ? 334 VAL B CG2 1 
ATOM   6526  N N   . ARG B 1 335 ? 15.299  71.602  -18.649 1.00 51.41  ? 335 ARG B N   1 
ATOM   6527  C CA  . ARG B 1 335 ? 14.763  70.626  -17.716 1.00 55.18  ? 335 ARG B CA  1 
ATOM   6528  C C   . ARG B 1 335 ? 13.816  69.671  -18.440 1.00 46.37  ? 335 ARG B C   1 
ATOM   6529  O O   . ARG B 1 335 ? 13.821  68.480  -18.157 1.00 51.36  ? 335 ARG B O   1 
ATOM   6530  C CB  . ARG B 1 335 ? 14.077  71.269  -16.504 1.00 55.38  ? 335 ARG B CB  1 
ATOM   6531  C CG  . ARG B 1 335 ? 13.573  70.234  -15.508 1.00 57.53  ? 335 ARG B CG  1 
ATOM   6532  C CD  . ARG B 1 335 ? 13.548  70.736  -14.068 1.00 59.73  ? 335 ARG B CD  1 
ATOM   6533  N NE  . ARG B 1 335 ? 12.807  72.005  -14.036 1.00 64.42  ? 335 ARG B NE  1 
ATOM   6534  C CZ  . ARG B 1 335 ? 11.508  72.094  -13.806 1.00 60.04  ? 335 ARG B CZ  1 
ATOM   6535  N NH1 . ARG B 1 335 ? 10.810  70.989  -13.632 1.00 52.55  ? 335 ARG B NH1 1 
ATOM   6536  N NH2 . ARG B 1 335 ? 10.919  73.279  -13.763 1.00 62.46  ? 335 ARG B NH2 1 
ATOM   6537  N N   . PHE B 1 336 ? 13.032  70.186  -19.389 1.00 48.69  ? 336 PHE B N   1 
ATOM   6538  C CA  . PHE B 1 336 ? 12.127  69.349  -20.157 1.00 47.79  ? 336 PHE B CA  1 
ATOM   6539  C C   . PHE B 1 336 ? 12.944  68.280  -20.871 1.00 46.51  ? 336 PHE B C   1 
ATOM   6540  O O   . PHE B 1 336 ? 12.615  67.101  -20.819 1.00 45.70  ? 336 PHE B O   1 
ATOM   6541  C CB  . PHE B 1 336 ? 11.309  70.217  -21.114 1.00 50.49  ? 336 PHE B CB  1 
ATOM   6542  C CG  . PHE B 1 336 ? 10.368  69.447  -22.025 1.00 50.11  ? 336 PHE B CG  1 
ATOM   6543  C CD1 . PHE B 1 336 ? 9.295   68.736  -21.499 1.00 52.56  ? 336 PHE B CD1 1 
ATOM   6544  C CD2 . PHE B 1 336 ? 10.565  69.434  -23.404 1.00 47.45  ? 336 PHE B CD2 1 
ATOM   6545  C CE1 . PHE B 1 336 ? 8.442   68.024  -22.333 1.00 59.67  ? 336 PHE B CE1 1 
ATOM   6546  C CE2 . PHE B 1 336 ? 9.720   68.708  -24.228 1.00 52.00  ? 336 PHE B CE2 1 
ATOM   6547  C CZ  . PHE B 1 336 ? 8.659   68.004  -23.694 1.00 54.21  ? 336 PHE B CZ  1 
ATOM   6548  N N   . ARG B 1 337 ? 14.050  68.687  -21.489 1.00 44.94  ? 337 ARG B N   1 
ATOM   6549  C CA  . ARG B 1 337 ? 14.901  67.729  -22.168 1.00 47.93  ? 337 ARG B CA  1 
ATOM   6550  C C   . ARG B 1 337 ? 15.489  66.702  -21.191 1.00 47.27  ? 337 ARG B C   1 
ATOM   6551  O O   . ARG B 1 337 ? 15.514  65.492  -21.465 1.00 44.06  ? 337 ARG B O   1 
ATOM   6552  C CB  . ARG B 1 337 ? 15.955  68.508  -22.959 1.00 50.43  ? 337 ARG B CB  1 
ATOM   6553  C CG  . ARG B 1 337 ? 16.902  67.619  -23.753 1.00 53.79  ? 337 ARG B CG  1 
ATOM   6554  C CD  . ARG B 1 337 ? 18.088  67.143  -22.940 1.00 51.05  ? 337 ARG B CD  1 
ATOM   6555  N NE  . ARG B 1 337 ? 18.981  66.382  -23.817 1.00 62.33  ? 337 ARG B NE  1 
ATOM   6556  C CZ  . ARG B 1 337 ? 20.310  66.414  -23.863 1.00 60.41  ? 337 ARG B CZ  1 
ATOM   6557  N NH1 . ARG B 1 337 ? 21.003  67.115  -22.979 1.00 54.24  ? 337 ARG B NH1 1 
ATOM   6558  N NH2 . ARG B 1 337 ? 20.932  65.716  -24.804 1.00 58.96  ? 337 ARG B NH2 1 
ATOM   6559  N N   . GLU B 1 338 ? 16.006  67.178  -20.060 1.00 41.09  ? 338 GLU B N   1 
ATOM   6560  C CA  . GLU B 1 338 ? 16.745  66.297  -19.177 1.00 44.83  ? 338 GLU B CA  1 
ATOM   6561  C C   . GLU B 1 338 ? 15.776  65.334  -18.493 1.00 47.49  ? 338 GLU B C   1 
ATOM   6562  O O   . GLU B 1 338 ? 16.169  64.233  -18.102 1.00 50.31  ? 338 GLU B O   1 
ATOM   6563  C CB  . GLU B 1 338 ? 17.604  67.066  -18.168 1.00 48.79  ? 338 GLU B CB  1 
ATOM   6564  C CG  . GLU B 1 338 ? 18.779  67.823  -18.781 1.00 50.24  ? 338 GLU B CG  1 
ATOM   6565  C CD  . GLU B 1 338 ? 19.841  66.957  -19.450 1.00 54.88  ? 338 GLU B CD  1 
ATOM   6566  O OE1 . GLU B 1 338 ? 19.795  65.711  -19.308 1.00 59.99  ? 338 GLU B OE1 1 
ATOM   6567  O OE2 . GLU B 1 338 ? 20.730  67.533  -20.117 1.00 57.44  ? 338 GLU B OE2 1 
ATOM   6568  N N   . THR B 1 339 ? 14.512  65.733  -18.337 1.00 45.31  ? 339 THR B N   1 
ATOM   6569  C CA  . THR B 1 339 ? 13.528  64.813  -17.782 1.00 50.83  ? 339 THR B CA  1 
ATOM   6570  C C   . THR B 1 339 ? 13.326  63.628  -18.746 1.00 50.69  ? 339 THR B C   1 
ATOM   6571  O O   . THR B 1 339 ? 13.346  62.457  -18.329 1.00 47.88  ? 339 THR B O   1 
ATOM   6572  C CB  . THR B 1 339 ? 12.219  65.547  -17.459 1.00 52.79  ? 339 THR B CB  1 
ATOM   6573  O OG1 . THR B 1 339 ? 12.513  66.597  -16.544 1.00 48.76  ? 339 THR B OG1 1 
ATOM   6574  C CG2 . THR B 1 339 ? 11.195  64.650  -16.777 1.00 51.65  ? 339 THR B CG2 1 
ATOM   6575  N N   . CYS B 1 340 ? 13.122  63.916  -20.038 1.00 46.42  ? 340 CYS B N   1 
ATOM   6576  C CA  . CYS B 1 340 ? 12.943  62.860  -21.028 1.00 46.34  ? 340 CYS B CA  1 
ATOM   6577  C C   . CYS B 1 340 ? 14.160  61.927  -21.016 1.00 51.83  ? 340 CYS B C   1 
ATOM   6578  O O   . CYS B 1 340 ? 14.025  60.706  -20.903 1.00 48.87  ? 340 CYS B O   1 
ATOM   6579  C CB  . CYS B 1 340 ? 12.670  63.463  -22.395 1.00 45.83  ? 340 CYS B CB  1 
ATOM   6580  S SG  . CYS B 1 340 ? 11.135  64.418  -22.427 1.00 51.03  ? 340 CYS B SG  1 
ATOM   6581  N N   . LYS B 1 341 ? 15.356  62.527  -21.025 1.00 47.47  ? 341 LYS B N   1 
ATOM   6582  C CA  . LYS B 1 341 ? 16.595  61.764  -21.006 1.00 56.74  ? 341 LYS B CA  1 
ATOM   6583  C C   . LYS B 1 341 ? 16.667  60.880  -19.748 1.00 58.84  ? 341 LYS B C   1 
ATOM   6584  O O   . LYS B 1 341 ? 17.021  59.700  -19.820 1.00 46.26  ? 341 LYS B O   1 
ATOM   6585  C CB  . LYS B 1 341 ? 17.771  62.741  -21.154 1.00 50.68  ? 341 LYS B CB  1 
ATOM   6586  C CG  . LYS B 1 341 ? 19.089  62.077  -21.454 1.00 56.64  ? 341 LYS B CG  1 
ATOM   6587  C CD  . LYS B 1 341 ? 20.194  62.964  -22.022 1.00 59.14  ? 341 LYS B CD  1 
ATOM   6588  C CE  . LYS B 1 341 ? 21.412  62.113  -22.277 1.00 57.08  ? 341 LYS B CE  1 
ATOM   6589  N NZ  . LYS B 1 341 ? 22.598  62.927  -22.499 1.00 56.59  ? 341 LYS B NZ  1 
ATOM   6590  N N   . ALA B 1 342 ? 16.340  61.456  -18.584 1.00 57.31  ? 342 ALA B N   1 
ATOM   6591  C CA  . ALA B 1 342 ? 16.427  60.733  -17.327 1.00 54.07  ? 342 ALA B CA  1 
ATOM   6592  C C   . ALA B 1 342 ? 15.488  59.529  -17.348 1.00 51.53  ? 342 ALA B C   1 
ATOM   6593  O O   . ALA B 1 342 ? 15.839  58.484  -16.806 1.00 48.83  ? 342 ALA B O   1 
ATOM   6594  C CB  . ALA B 1 342 ? 16.123  61.654  -16.158 1.00 53.40  ? 342 ALA B CB  1 
ATOM   6595  N N   . PHE B 1 343 ? 14.307  59.654  -17.980 1.00 47.91  ? 343 PHE B N   1 
ATOM   6596  C CA  . PHE B 1 343 ? 13.388  58.520  -18.047 1.00 49.93  ? 343 PHE B CA  1 
ATOM   6597  C C   . PHE B 1 343 ? 13.920  57.392  -18.946 1.00 52.03  ? 343 PHE B C   1 
ATOM   6598  O O   . PHE B 1 343 ? 13.786  56.218  -18.592 1.00 54.01  ? 343 PHE B O   1 
ATOM   6599  C CB  . PHE B 1 343 ? 11.992  58.941  -18.496 1.00 48.81  ? 343 PHE B CB  1 
ATOM   6600  C CG  . PHE B 1 343 ? 11.055  59.307  -17.357 1.00 50.51  ? 343 PHE B CG  1 
ATOM   6601  C CD1 . PHE B 1 343 ? 10.504  58.313  -16.546 1.00 51.14  ? 343 PHE B CD1 1 
ATOM   6602  C CD2 . PHE B 1 343 ? 10.712  60.636  -17.104 1.00 48.99  ? 343 PHE B CD2 1 
ATOM   6603  C CE1 . PHE B 1 343 ? 9.618   58.636  -15.524 1.00 52.83  ? 343 PHE B CE1 1 
ATOM   6604  C CE2 . PHE B 1 343 ? 9.805   60.954  -16.096 1.00 50.00  ? 343 PHE B CE2 1 
ATOM   6605  C CZ  . PHE B 1 343 ? 9.265   59.961  -15.303 1.00 49.28  ? 343 PHE B CZ  1 
ATOM   6606  N N   . ALA B 1 344 ? 14.512  57.748  -20.099 1.00 45.89  ? 344 ALA B N   1 
ATOM   6607  C CA  . ALA B 1 344 ? 15.136  56.793  -21.012 1.00 50.31  ? 344 ALA B CA  1 
ATOM   6608  C C   . ALA B 1 344 ? 16.293  56.041  -20.351 1.00 50.47  ? 344 ALA B C   1 
ATOM   6609  O O   . ALA B 1 344 ? 16.419  54.836  -20.549 1.00 50.63  ? 344 ALA B O   1 
ATOM   6610  C CB  . ALA B 1 344 ? 15.652  57.510  -22.242 1.00 55.96  ? 344 ALA B CB  1 
ATOM   6611  N N   . ILE B 1 345 ? 17.164  56.767  -19.629 1.00 47.70  ? 345 ILE B N   1 
ATOM   6612  C CA  . ILE B 1 345 ? 18.236  56.167  -18.853 1.00 47.54  ? 345 ILE B CA  1 
ATOM   6613  C C   . ILE B 1 345 ? 17.673  55.270  -17.756 1.00 52.89  ? 345 ILE B C   1 
ATOM   6614  O O   . ILE B 1 345 ? 18.205  54.191  -17.529 1.00 53.13  ? 345 ILE B O   1 
ATOM   6615  C CB  . ILE B 1 345 ? 19.143  57.239  -18.243 1.00 56.00  ? 345 ILE B CB  1 
ATOM   6616  C CG1 . ILE B 1 345 ? 20.063  57.831  -19.302 1.00 54.48  ? 345 ILE B CG1 1 
ATOM   6617  C CG2 . ILE B 1 345 ? 19.923  56.672  -17.052 1.00 63.97  ? 345 ILE B CG2 1 
ATOM   6618  C CD1 . ILE B 1 345 ? 20.602  59.194  -18.931 1.00 55.70  ? 345 ILE B CD1 1 
ATOM   6619  N N   . ALA B 1 346 ? 16.608  55.691  -17.063 1.00 52.40  ? 346 ALA B N   1 
ATOM   6620  C CA  . ALA B 1 346 ? 16.106  54.861  -15.976 1.00 51.75  ? 346 ALA B CA  1 
ATOM   6621  C C   . ALA B 1 346 ? 15.436  53.602  -16.533 1.00 51.25  ? 346 ALA B C   1 
ATOM   6622  O O   . ALA B 1 346 ? 15.481  52.541  -15.902 1.00 46.94  ? 346 ALA B O   1 
ATOM   6623  C CB  . ALA B 1 346 ? 15.174  55.643  -15.075 1.00 48.21  ? 346 ALA B CB  1 
ATOM   6624  N N   . ALA B 1 347 ? 14.796  53.732  -17.706 1.00 47.01  ? 347 ALA B N   1 
ATOM   6625  C CA  . ALA B 1 347 ? 14.050  52.632  -18.287 1.00 50.72  ? 347 ALA B CA  1 
ATOM   6626  C C   . ALA B 1 347 ? 15.020  51.510  -18.650 1.00 55.60  ? 347 ALA B C   1 
ATOM   6627  O O   . ALA B 1 347 ? 14.758  50.336  -18.394 1.00 47.62  ? 347 ALA B O   1 
ATOM   6628  C CB  . ALA B 1 347 ? 13.268  53.107  -19.492 1.00 53.33  ? 347 ALA B CB  1 
ATOM   6629  N N   . GLU B 1 348 ? 16.143  51.906  -19.255 1.00 55.95  ? 348 GLU B N   1 
ATOM   6630  C CA  . GLU B 1 348 ? 17.163  50.972  -19.684 1.00 56.89  ? 348 GLU B CA  1 
ATOM   6631  C C   . GLU B 1 348 ? 17.852  50.370  -18.466 1.00 55.18  ? 348 GLU B C   1 
ATOM   6632  O O   . GLU B 1 348 ? 17.977  49.157  -18.352 1.00 58.60  ? 348 GLU B O   1 
ATOM   6633  C CB  . GLU B 1 348 ? 18.167  51.712  -20.556 1.00 55.95  ? 348 GLU B CB  1 
ATOM   6634  C CG  . GLU B 1 348 ? 19.238  50.784  -21.109 1.00 60.38  ? 348 GLU B CG  1 
ATOM   6635  C CD  . GLU B 1 348 ? 20.123  51.546  -22.060 1.00 65.20  ? 348 GLU B CD  1 
ATOM   6636  O OE1 . GLU B 1 348 ? 19.575  51.916  -23.155 1.00 52.43  ? 348 GLU B OE1 1 
ATOM   6637  O OE2 . GLU B 1 348 ? 21.306  51.791  -21.654 1.00 60.80  ? 348 GLU B OE2 1 
ATOM   6638  N N   . GLU B 1 349 ? 18.270  51.234  -17.545 1.00 56.41  ? 349 GLU B N   1 
ATOM   6639  C CA  . GLU B 1 349 ? 18.999  50.821  -16.358 1.00 56.66  ? 349 GLU B CA  1 
ATOM   6640  C C   . GLU B 1 349 ? 18.222  49.776  -15.550 1.00 55.24  ? 349 GLU B C   1 
ATOM   6641  O O   . GLU B 1 349 ? 18.844  48.892  -14.984 1.00 50.05  ? 349 GLU B O   1 
ATOM   6642  C CB  . GLU B 1 349 ? 19.376  52.063  -15.543 1.00 61.13  ? 349 GLU B CB  1 
ATOM   6643  C CG  . GLU B 1 349 ? 20.052  51.762  -14.209 1.00 70.14  ? 349 GLU B CG  1 
ATOM   6644  C CD  . GLU B 1 349 ? 21.230  50.797  -14.241 1.00 71.77  ? 349 GLU B CD  1 
ATOM   6645  O OE1 . GLU B 1 349 ? 21.824  50.553  -15.317 1.00 78.15  ? 349 GLU B OE1 1 
ATOM   6646  O OE2 . GLU B 1 349 ? 21.522  50.266  -13.157 1.00 63.16  ? 349 GLU B OE2 1 
ATOM   6647  N N   . THR B 1 350 ? 16.880  49.857  -15.498 1.00 57.41  ? 350 THR B N   1 
ATOM   6648  C CA  . THR B 1 350 ? 16.083  48.955  -14.671 1.00 51.42  ? 350 THR B CA  1 
ATOM   6649  C C   . THR B 1 350 ? 15.344  47.927  -15.528 1.00 49.49  ? 350 THR B C   1 
ATOM   6650  O O   . THR B 1 350 ? 14.400  47.282  -15.052 1.00 48.51  ? 350 THR B O   1 
ATOM   6651  C CB  . THR B 1 350 ? 15.108  49.776  -13.822 1.00 57.10  ? 350 THR B CB  1 
ATOM   6652  O OG1 . THR B 1 350 ? 14.214  50.424  -14.730 1.00 56.14  ? 350 THR B OG1 1 
ATOM   6653  C CG2 . THR B 1 350 ? 15.842  50.752  -12.913 1.00 55.64  ? 350 THR B CG2 1 
ATOM   6654  N N   . GLY B 1 351 ? 15.786  47.768  -16.787 1.00 49.42  ? 351 GLY B N   1 
ATOM   6655  C CA  . GLY B 1 351 ? 15.259  46.734  -17.662 1.00 58.24  ? 351 GLY B CA  1 
ATOM   6656  C C   . GLY B 1 351 ? 15.634  45.329  -17.180 1.00 60.15  ? 351 GLY B C   1 
ATOM   6657  O O   . GLY B 1 351 ? 16.432  45.175  -16.254 1.00 55.58  ? 351 GLY B O   1 
ATOM   6658  N N   . PHE B 1 352 ? 15.056  44.321  -17.847 1.00 66.90  ? 352 PHE B N   1 
ATOM   6659  C CA  . PHE B 1 352 ? 15.108  42.925  -17.430 1.00 78.96  ? 352 PHE B CA  1 
ATOM   6660  C C   . PHE B 1 352 ? 14.947  42.052  -18.682 1.00 74.97  ? 352 PHE B C   1 
ATOM   6661  O O   . PHE B 1 352 ? 14.376  42.498  -19.678 1.00 62.76  ? 352 PHE B O   1 
ATOM   6662  C CB  . PHE B 1 352 ? 13.994  42.697  -16.395 1.00 83.32  ? 352 PHE B CB  1 
ATOM   6663  C CG  . PHE B 1 352 ? 12.597  42.854  -16.990 1.00 95.17  ? 352 PHE B CG  1 
ATOM   6664  C CD1 . PHE B 1 352 ? 12.018  44.116  -17.149 1.00 104.71 ? 352 PHE B CD1 1 
ATOM   6665  C CD2 . PHE B 1 352 ? 11.882  41.742  -17.444 1.00 102.88 ? 352 PHE B CD2 1 
ATOM   6666  C CE1 . PHE B 1 352 ? 10.759  44.259  -17.731 1.00 110.70 ? 352 PHE B CE1 1 
ATOM   6667  C CE2 . PHE B 1 352 ? 10.621  41.888  -18.022 1.00 110.98 ? 352 PHE B CE2 1 
ATOM   6668  C CZ  . PHE B 1 352 ? 10.060  43.144  -18.161 1.00 112.05 ? 352 PHE B CZ  1 
ATOM   6669  N N   . THR B 1 353 ? 15.427  40.800  -18.638 1.00 68.80  ? 353 THR B N   1 
ATOM   6670  C CA  . THR B 1 353 ? 15.322  39.918  -19.793 1.00 68.89  ? 353 THR B CA  1 
ATOM   6671  C C   . THR B 1 353 ? 13.972  39.206  -19.736 1.00 63.44  ? 353 THR B C   1 
ATOM   6672  O O   . THR B 1 353 ? 13.516  38.863  -18.658 1.00 64.25  ? 353 THR B O   1 
ATOM   6673  C CB  . THR B 1 353 ? 16.523  38.964  -19.856 1.00 73.95  ? 353 THR B CB  1 
ATOM   6674  O OG1 . THR B 1 353 ? 16.910  38.622  -18.530 1.00 78.27  ? 353 THR B OG1 1 
ATOM   6675  C CG2 . THR B 1 353 ? 17.753  39.590  -20.495 1.00 69.04  ? 353 THR B CG2 1 
ATOM   6676  N N   . THR B 1 354 ? 13.322  39.008  -20.893 1.00 68.72  ? 354 THR B N   1 
ATOM   6677  C CA  . THR B 1 354 ? 12.063  38.270  -20.960 1.00 78.58  ? 354 THR B CA  1 
ATOM   6678  C C   . THR B 1 354 ? 12.325  36.765  -20.807 1.00 79.27  ? 354 THR B C   1 
ATOM   6679  O O   . THR B 1 354 ? 13.466  36.342  -20.622 1.00 73.03  ? 354 THR B O   1 
ATOM   6680  C CB  . THR B 1 354 ? 11.349  38.577  -22.278 1.00 79.63  ? 354 THR B CB  1 
ATOM   6681  O OG1 . THR B 1 354 ? 12.241  38.120  -23.288 1.00 84.94  ? 354 THR B OG1 1 
ATOM   6682  C CG2 . THR B 1 354 ? 11.046  40.053  -22.465 1.00 82.59  ? 354 THR B CG2 1 
ATOM   6683  N N   . ALA B 1 355 ? 11.258  35.953  -20.862 1.00 82.15  ? 355 ALA B N   1 
ATOM   6684  C CA  . ALA B 1 355 ? 11.389  34.499  -20.913 1.00 88.38  ? 355 ALA B CA  1 
ATOM   6685  C C   . ALA B 1 355 ? 12.343  34.089  -22.035 1.00 81.92  ? 355 ALA B C   1 
ATOM   6686  O O   . ALA B 1 355 ? 13.345  33.412  -21.784 1.00 68.98  ? 355 ALA B O   1 
ATOM   6687  C CB  . ALA B 1 355 ? 10.032  33.857  -21.117 1.00 92.34  ? 355 ALA B CB  1 
ATOM   6688  N N   . GLY B 1 356 ? 12.037  34.568  -23.253 1.00 72.16  ? 356 GLY B N   1 
ATOM   6689  C CA  . GLY B 1 356 ? 12.760  34.213  -24.468 1.00 70.59  ? 356 GLY B CA  1 
ATOM   6690  C C   . GLY B 1 356 ? 14.196  34.749  -24.561 1.00 66.61  ? 356 GLY B C   1 
ATOM   6691  O O   . GLY B 1 356 ? 14.878  34.439  -25.542 1.00 60.14  ? 356 GLY B O   1 
ATOM   6692  N N   . GLY B 1 357 ? 14.642  35.575  -23.592 1.00 62.93  ? 357 GLY B N   1 
ATOM   6693  C CA  . GLY B 1 357 ? 16.009  36.088  -23.542 1.00 60.26  ? 357 GLY B CA  1 
ATOM   6694  C C   . GLY B 1 357 ? 16.156  37.512  -24.109 1.00 61.57  ? 357 GLY B C   1 
ATOM   6695  O O   . GLY B 1 357 ? 17.280  37.966  -24.376 1.00 53.94  ? 357 GLY B O   1 
ATOM   6696  N N   . LEU B 1 358 ? 15.030  38.216  -24.309 1.00 52.86  ? 358 LEU B N   1 
ATOM   6697  C CA  . LEU B 1 358 ? 15.054  39.568  -24.861 1.00 63.20  ? 358 LEU B CA  1 
ATOM   6698  C C   . LEU B 1 358 ? 15.222  40.582  -23.731 1.00 55.96  ? 358 LEU B C   1 
ATOM   6699  O O   . LEU B 1 358 ? 14.379  40.607  -22.836 1.00 59.03  ? 358 LEU B O   1 
ATOM   6700  C CB  . LEU B 1 358 ? 13.743  39.812  -25.610 1.00 69.29  ? 358 LEU B CB  1 
ATOM   6701  C CG  . LEU B 1 358 ? 13.739  40.922  -26.666 1.00 77.29  ? 358 LEU B CG  1 
ATOM   6702  C CD1 . LEU B 1 358 ? 14.555  40.524  -27.888 1.00 82.83  ? 358 LEU B CD1 1 
ATOM   6703  C CD2 . LEU B 1 358 ? 12.305  41.240  -27.067 1.00 82.08  ? 358 LEU B CD2 1 
ATOM   6704  N N   . PHE B 1 359 ? 16.284  41.407  -23.779 1.00 57.93  ? 359 PHE B N   1 
ATOM   6705  C CA  . PHE B 1 359 ? 16.463  42.486  -22.807 1.00 66.58  ? 359 PHE B CA  1 
ATOM   6706  C C   . PHE B 1 359 ? 15.598  43.689  -23.182 1.00 67.15  ? 359 PHE B C   1 
ATOM   6707  O O   . PHE B 1 359 ? 15.823  44.341  -24.204 1.00 64.35  ? 359 PHE B O   1 
ATOM   6708  C CB  . PHE B 1 359 ? 17.883  43.027  -22.621 1.00 67.99  ? 359 PHE B CB  1 
ATOM   6709  C CG  . PHE B 1 359 ? 18.035  44.017  -21.466 1.00 69.35  ? 359 PHE B CG  1 
ATOM   6710  C CD1 . PHE B 1 359 ? 17.737  45.371  -21.635 1.00 69.35  ? 359 PHE B CD1 1 
ATOM   6711  C CD2 . PHE B 1 359 ? 18.500  43.597  -20.217 1.00 66.24  ? 359 PHE B CD2 1 
ATOM   6712  C CE1 . PHE B 1 359 ? 17.904  46.270  -20.587 1.00 68.09  ? 359 PHE B CE1 1 
ATOM   6713  C CE2 . PHE B 1 359 ? 18.674  44.500  -19.175 1.00 65.72  ? 359 PHE B CE2 1 
ATOM   6714  C CZ  . PHE B 1 359 ? 18.374  45.834  -19.363 1.00 68.00  ? 359 PHE B CZ  1 
ATOM   6715  N N   . LYS B 1 360 ? 14.647  43.993  -22.292 1.00 67.81  ? 360 LYS B N   1 
ATOM   6716  C CA  . LYS B 1 360 ? 13.585  44.954  -22.528 1.00 69.63  ? 360 LYS B CA  1 
ATOM   6717  C C   . LYS B 1 360 ? 13.693  46.049  -21.472 1.00 63.83  ? 360 LYS B C   1 
ATOM   6718  O O   . LYS B 1 360 ? 13.636  45.757  -20.277 1.00 62.88  ? 360 LYS B O   1 
ATOM   6719  C CB  . LYS B 1 360 ? 12.266  44.179  -22.427 1.00 75.50  ? 360 LYS B CB  1 
ATOM   6720  C CG  . LYS B 1 360 ? 10.941  44.915  -22.644 1.00 76.45  ? 360 LYS B CG  1 
ATOM   6721  C CD  . LYS B 1 360 ? 9.797   44.065  -22.098 1.00 80.42  ? 360 LYS B CD  1 
ATOM   6722  C CE  . LYS B 1 360 ? 8.491   44.774  -21.969 1.00 84.48  ? 360 LYS B CE  1 
ATOM   6723  N NZ  . LYS B 1 360 ? 7.811   44.858  -23.261 1.00 86.61  ? 360 LYS B NZ  1 
ATOM   6724  N N   . PRO B 1 361 ? 13.908  47.321  -21.877 1.00 56.75  ? 361 PRO B N   1 
ATOM   6725  C CA  . PRO B 1 361 ? 13.723  48.464  -20.982 1.00 55.75  ? 361 PRO B CA  1 
ATOM   6726  C C   . PRO B 1 361 ? 12.425  48.414  -20.176 1.00 56.54  ? 361 PRO B C   1 
ATOM   6727  O O   . PRO B 1 361 ? 11.399  47.956  -20.681 1.00 50.84  ? 361 PRO B O   1 
ATOM   6728  C CB  . PRO B 1 361 ? 13.746  49.657  -21.952 1.00 55.45  ? 361 PRO B CB  1 
ATOM   6729  C CG  . PRO B 1 361 ? 14.676  49.210  -23.063 1.00 59.22  ? 361 PRO B CG  1 
ATOM   6730  C CD  . PRO B 1 361 ? 14.436  47.716  -23.195 1.00 60.28  ? 361 PRO B CD  1 
ATOM   6731  N N   . ASN B 1 362 ? 12.507  48.917  -18.930 1.00 59.53  ? 362 ASN B N   1 
ATOM   6732  C CA  . ASN B 1 362 ? 11.397  48.989  -17.987 1.00 58.68  ? 362 ASN B CA  1 
ATOM   6733  C C   . ASN B 1 362 ? 10.282  49.893  -18.522 1.00 56.43  ? 362 ASN B C   1 
ATOM   6734  O O   . ASN B 1 362 ? 10.456  51.108  -18.588 1.00 54.09  ? 362 ASN B O   1 
ATOM   6735  C CB  . ASN B 1 362 ? 11.927  49.490  -16.648 1.00 56.66  ? 362 ASN B CB  1 
ATOM   6736  C CG  . ASN B 1 362 ? 10.934  49.395  -15.510 1.00 58.43  ? 362 ASN B CG  1 
ATOM   6737  O OD1 . ASN B 1 362 ? 9.757   49.052  -15.684 1.00 50.84  ? 362 ASN B OD1 1 
ATOM   6738  N ND2 . ASN B 1 362 ? 11.400  49.727  -14.319 1.00 59.02  ? 362 ASN B ND2 1 
ATOM   6739  N N   . ASN B 1 363 ? 9.115   49.313  -18.843 1.00 54.42  ? 363 ASN B N   1 
ATOM   6740  C CA  . ASN B 1 363 ? 8.042   50.065  -19.484 1.00 58.01  ? 363 ASN B CA  1 
ATOM   6741  C C   . ASN B 1 363 ? 7.418   51.110  -18.541 1.00 63.09  ? 363 ASN B C   1 
ATOM   6742  O O   . ASN B 1 363 ? 6.721   52.017  -19.013 1.00 53.25  ? 363 ASN B O   1 
ATOM   6743  C CB  . ASN B 1 363 ? 6.992   49.154  -20.120 1.00 59.16  ? 363 ASN B CB  1 
ATOM   6744  C CG  . ASN B 1 363 ? 6.358   48.196  -19.135 1.00 70.80  ? 363 ASN B CG  1 
ATOM   6745  O OD1 . ASN B 1 363 ? 6.618   48.286  -17.933 1.00 66.52  ? 363 ASN B OD1 1 
ATOM   6746  N ND2 . ASN B 1 363 ? 5.538   47.270  -19.613 1.00 74.12  ? 363 ASN B ND2 1 
ATOM   6747  N N   . ILE B 1 364 ? 7.641   50.992  -17.219 1.00 58.03  ? 364 ILE B N   1 
ATOM   6748  C CA  . ILE B 1 364 ? 7.133   51.983  -16.277 1.00 58.60  ? 364 ILE B CA  1 
ATOM   6749  C C   . ILE B 1 364 ? 7.816   53.328  -16.523 1.00 52.10  ? 364 ILE B C   1 
ATOM   6750  O O   . ILE B 1 364 ? 7.151   54.352  -16.638 1.00 45.65  ? 364 ILE B O   1 
ATOM   6751  C CB  . ILE B 1 364 ? 7.274   51.514  -14.816 1.00 69.93  ? 364 ILE B CB  1 
ATOM   6752  C CG1 . ILE B 1 364 ? 6.126   50.550  -14.450 1.00 76.42  ? 364 ILE B CG1 1 
ATOM   6753  C CG2 . ILE B 1 364 ? 7.355   52.699  -13.844 1.00 66.42  ? 364 ILE B CG2 1 
ATOM   6754  C CD1 . ILE B 1 364 ? 6.138   50.060  -13.009 1.00 74.52  ? 364 ILE B CD1 1 
ATOM   6755  N N   . TYR B 1 365 ? 9.141   53.337  -16.644 1.00 50.26  ? 365 TYR B N   1 
ATOM   6756  C CA  . TYR B 1 365 ? 9.834   54.584  -16.917 1.00 51.66  ? 365 TYR B CA  1 
ATOM   6757  C C   . TYR B 1 365 ? 9.605   55.017  -18.365 1.00 54.32  ? 365 TYR B C   1 
ATOM   6758  O O   . TYR B 1 365 ? 9.444   56.209  -18.610 1.00 49.68  ? 365 TYR B O   1 
ATOM   6759  C CB  . TYR B 1 365 ? 11.309  54.474  -16.533 1.00 59.17  ? 365 TYR B CB  1 
ATOM   6760  C CG  . TYR B 1 365 ? 11.502  54.255  -15.042 1.00 59.13  ? 365 TYR B CG  1 
ATOM   6761  C CD1 . TYR B 1 365 ? 11.207  55.264  -14.126 1.00 59.39  ? 365 TYR B CD1 1 
ATOM   6762  C CD2 . TYR B 1 365 ? 11.977  53.044  -14.555 1.00 59.03  ? 365 TYR B CD2 1 
ATOM   6763  C CE1 . TYR B 1 365 ? 11.378  55.068  -12.764 1.00 64.33  ? 365 TYR B CE1 1 
ATOM   6764  C CE2 . TYR B 1 365 ? 12.165  52.845  -13.197 1.00 66.44  ? 365 TYR B CE2 1 
ATOM   6765  C CZ  . TYR B 1 365 ? 11.854  53.854  -12.298 1.00 69.61  ? 365 TYR B CZ  1 
ATOM   6766  O OH  . TYR B 1 365 ? 12.034  53.644  -10.960 1.00 76.08  ? 365 TYR B OH  1 
ATOM   6767  N N   . VAL B 1 366 ? 9.518   54.069  -19.311 1.00 54.08  ? 366 VAL B N   1 
ATOM   6768  C CA  . VAL B 1 366 ? 9.236   54.436  -20.695 1.00 56.81  ? 366 VAL B CA  1 
ATOM   6769  C C   . VAL B 1 366 ? 7.893   55.182  -20.769 1.00 53.36  ? 366 VAL B C   1 
ATOM   6770  O O   . VAL B 1 366 ? 7.794   56.235  -21.407 1.00 44.00  ? 366 VAL B O   1 
ATOM   6771  C CB  . VAL B 1 366 ? 9.254   53.241  -21.674 1.00 58.23  ? 366 VAL B CB  1 
ATOM   6772  C CG1 . VAL B 1 366 ? 9.029   53.678  -23.121 1.00 57.30  ? 366 VAL B CG1 1 
ATOM   6773  C CG2 . VAL B 1 366 ? 10.545  52.442  -21.593 1.00 58.15  ? 366 VAL B CG2 1 
ATOM   6774  N N   . ASP B 1 367 ? 6.840   54.625  -20.151 1.00 52.08  ? 367 ASP B N   1 
ATOM   6775  C CA  . ASP B 1 367 ? 5.488   55.142  -20.353 1.00 55.81  ? 367 ASP B CA  1 
ATOM   6776  C C   . ASP B 1 367 ? 5.293   56.454  -19.595 1.00 58.14  ? 367 ASP B C   1 
ATOM   6777  O O   . ASP B 1 367 ? 4.593   57.351  -20.070 1.00 55.16  ? 367 ASP B O   1 
ATOM   6778  C CB  . ASP B 1 367 ? 4.418   54.108  -20.031 1.00 55.18  ? 367 ASP B CB  1 
ATOM   6779  C CG  . ASP B 1 367 ? 4.324   52.934  -21.004 1.00 64.66  ? 367 ASP B CG  1 
ATOM   6780  O OD1 . ASP B 1 367 ? 4.748   53.091  -22.179 1.00 59.86  ? 367 ASP B OD1 1 
ATOM   6781  O OD2 . ASP B 1 367 ? 3.872   51.850  -20.561 1.00 74.12  ? 367 ASP B OD2 1 
ATOM   6782  N N   . LEU B 1 368 ? 5.923   56.565  -18.421 1.00 52.31  ? 368 LEU B N   1 
ATOM   6783  C CA  . LEU B 1 368 ? 5.778   57.765  -17.628 1.00 52.68  ? 368 LEU B CA  1 
ATOM   6784  C C   . LEU B 1 368 ? 6.647   58.875  -18.216 1.00 48.01  ? 368 LEU B C   1 
ATOM   6785  O O   . LEU B 1 368 ? 6.308   60.045  -18.072 1.00 43.54  ? 368 LEU B O   1 
ATOM   6786  C CB  . LEU B 1 368 ? 6.032   57.508  -16.144 1.00 51.80  ? 368 LEU B CB  1 
ATOM   6787  C CG  . LEU B 1 368 ? 5.040   56.549  -15.467 1.00 59.83  ? 368 LEU B CG  1 
ATOM   6788  C CD1 . LEU B 1 368 ? 5.263   56.561  -13.955 1.00 66.29  ? 368 LEU B CD1 1 
ATOM   6789  C CD2 . LEU B 1 368 ? 3.568   56.795  -15.769 1.00 57.29  ? 368 LEU B CD2 1 
ATOM   6790  N N   . GLY B 1 369 ? 7.740   58.508  -18.894 1.00 53.67  ? 369 GLY B N   1 
ATOM   6791  C CA  . GLY B 1 369 ? 8.536   59.464  -19.650 1.00 53.85  ? 369 GLY B CA  1 
ATOM   6792  C C   . GLY B 1 369 ? 7.723   60.033  -20.815 1.00 59.31  ? 369 GLY B C   1 
ATOM   6793  O O   . GLY B 1 369 ? 7.698   61.243  -21.058 1.00 51.85  ? 369 GLY B O   1 
ATOM   6794  N N   . ARG B 1 370 ? 7.034   59.137  -21.527 1.00 58.95  ? 370 ARG B N   1 
ATOM   6795  C CA  . ARG B 1 370 ? 6.153   59.556  -22.607 1.00 58.07  ? 370 ARG B CA  1 
ATOM   6796  C C   . ARG B 1 370 ? 5.097   60.515  -22.053 1.00 48.57  ? 370 ARG B C   1 
ATOM   6797  O O   . ARG B 1 370 ? 4.884   61.581  -22.610 1.00 45.62  ? 370 ARG B O   1 
ATOM   6798  C CB  . ARG B 1 370 ? 5.565   58.334  -23.324 1.00 53.58  ? 370 ARG B CB  1 
ATOM   6799  C CG  . ARG B 1 370 ? 6.527   57.671  -24.302 1.00 54.19  ? 370 ARG B CG  1 
ATOM   6800  C CD  . ARG B 1 370 ? 5.952   56.406  -24.897 1.00 54.08  ? 370 ARG B CD  1 
ATOM   6801  N NE  . ARG B 1 370 ? 4.602   56.686  -25.391 1.00 57.55  ? 370 ARG B NE  1 
ATOM   6802  C CZ  . ARG B 1 370 ? 3.470   56.215  -24.879 1.00 66.60  ? 370 ARG B CZ  1 
ATOM   6803  N NH1 . ARG B 1 370 ? 3.447   55.269  -23.938 1.00 72.28  ? 370 ARG B NH1 1 
ATOM   6804  N NH2 . ARG B 1 370 ? 2.342   56.702  -25.344 1.00 61.64  ? 370 ARG B NH2 1 
ATOM   6805  N N   . ALA B 1 371 ? 4.434   60.118  -20.965 1.00 45.68  ? 371 ALA B N   1 
ATOM   6806  C CA  . ALA B 1 371 ? 3.451   60.964  -20.314 1.00 47.30  ? 371 ALA B CA  1 
ATOM   6807  C C   . ALA B 1 371 ? 4.023   62.368  -20.104 1.00 46.46  ? 371 ALA B C   1 
ATOM   6808  O O   . ALA B 1 371 ? 3.355   63.345  -20.433 1.00 43.93  ? 371 ALA B O   1 
ATOM   6809  C CB  . ALA B 1 371 ? 3.008   60.340  -18.998 1.00 47.72  ? 371 ALA B CB  1 
ATOM   6810  N N   . HIS B 1 372 ? 5.242   62.459  -19.537 1.00 50.43  ? 372 HIS B N   1 
ATOM   6811  C CA  . HIS B 1 372 ? 5.840   63.743  -19.195 1.00 48.37  ? 372 HIS B CA  1 
ATOM   6812  C C   . HIS B 1 372 ? 5.928   64.583  -20.460 1.00 47.36  ? 372 HIS B C   1 
ATOM   6813  O O   . HIS B 1 372 ? 5.522   65.738  -20.448 1.00 47.70  ? 372 HIS B O   1 
ATOM   6814  C CB  . HIS B 1 372 ? 7.226   63.600  -18.551 1.00 49.10  ? 372 HIS B CB  1 
ATOM   6815  C CG  . HIS B 1 372 ? 7.840   64.923  -18.187 1.00 52.15  ? 372 HIS B CG  1 
ATOM   6816  N ND1 . HIS B 1 372 ? 8.619   65.671  -19.049 1.00 53.58  ? 372 HIS B ND1 1 
ATOM   6817  C CD2 . HIS B 1 372 ? 7.745   65.650  -17.062 1.00 52.69  ? 372 HIS B CD2 1 
ATOM   6818  C CE1 . HIS B 1 372 ? 9.001   66.786  -18.444 1.00 55.29  ? 372 HIS B CE1 1 
ATOM   6819  N NE2 . HIS B 1 372 ? 8.479   66.789  -17.240 1.00 52.80  ? 372 HIS B NE2 1 
ATOM   6820  N N   . TYR B 1 373 ? 6.464   63.968  -21.527 1.00 48.44  ? 373 TYR B N   1 
ATOM   6821  C CA  . TYR B 1 373 ? 6.573   64.585  -22.841 1.00 50.18  ? 373 TYR B CA  1 
ATOM   6822  C C   . TYR B 1 373 ? 5.192   65.035  -23.276 1.00 45.96  ? 373 TYR B C   1 
ATOM   6823  O O   . TYR B 1 373 ? 5.035   66.180  -23.693 1.00 46.68  ? 373 TYR B O   1 
ATOM   6824  C CB  . TYR B 1 373 ? 7.169   63.669  -23.923 1.00 50.19  ? 373 TYR B CB  1 
ATOM   6825  C CG  . TYR B 1 373 ? 7.277   64.255  -25.329 1.00 50.46  ? 373 TYR B CG  1 
ATOM   6826  C CD1 . TYR B 1 373 ? 6.221   64.176  -26.234 1.00 53.06  ? 373 TYR B CD1 1 
ATOM   6827  C CD2 . TYR B 1 373 ? 8.442   64.882  -25.762 1.00 57.94  ? 373 TYR B CD2 1 
ATOM   6828  C CE1 . TYR B 1 373 ? 6.310   64.711  -27.511 1.00 51.50  ? 373 TYR B CE1 1 
ATOM   6829  C CE2 . TYR B 1 373 ? 8.552   65.413  -27.039 1.00 53.89  ? 373 TYR B CE2 1 
ATOM   6830  C CZ  . TYR B 1 373 ? 7.484   65.325  -27.916 1.00 53.72  ? 373 TYR B CZ  1 
ATOM   6831  O OH  . TYR B 1 373 ? 7.589   65.857  -29.167 1.00 51.41  ? 373 TYR B OH  1 
ATOM   6832  N N   . LEU B 1 374 ? 4.229   64.111  -23.184 1.00 46.75  ? 374 LEU B N   1 
ATOM   6833  C CA  . LEU B 1 374 ? 2.910   64.299  -23.778 1.00 57.31  ? 374 LEU B CA  1 
ATOM   6834  C C   . LEU B 1 374 ? 2.137   65.416  -23.070 1.00 51.89  ? 374 LEU B C   1 
ATOM   6835  O O   . LEU B 1 374 ? 1.295   66.051  -23.686 1.00 42.40  ? 374 LEU B O   1 
ATOM   6836  C CB  . LEU B 1 374 ? 2.098   63.000  -23.756 1.00 61.15  ? 374 LEU B CB  1 
ATOM   6837  C CG  . LEU B 1 374 ? 2.511   61.893  -24.740 1.00 64.65  ? 374 LEU B CG  1 
ATOM   6838  C CD1 . LEU B 1 374 ? 1.636   60.634  -24.578 1.00 60.18  ? 374 LEU B CD1 1 
ATOM   6839  C CD2 . LEU B 1 374 ? 2.459   62.366  -26.184 1.00 59.22  ? 374 LEU B CD2 1 
ATOM   6840  N N   . GLU B 1 375 ? 2.356   65.580  -21.760 1.00 54.64  ? 375 GLU B N   1 
ATOM   6841  C CA  . GLU B 1 375 ? 1.669   66.589  -20.973 1.00 55.53  ? 375 GLU B CA  1 
ATOM   6842  C C   . GLU B 1 375 ? 2.251   67.974  -21.282 1.00 56.66  ? 375 GLU B C   1 
ATOM   6843  O O   . GLU B 1 375 ? 1.490   68.933  -21.307 1.00 51.86  ? 375 GLU B O   1 
ATOM   6844  C CB  . GLU B 1 375 ? 1.772   66.232  -19.486 1.00 53.34  ? 375 GLU B CB  1 
ATOM   6845  C CG  . GLU B 1 375 ? 1.401   67.350  -18.512 1.00 47.85  ? 375 GLU B CG  1 
ATOM   6846  C CD  . GLU B 1 375 ? 1.650   67.002  -17.044 1.00 52.46  ? 375 GLU B CD  1 
ATOM   6847  O OE1 . GLU B 1 375 ? 2.805   66.828  -16.590 1.00 44.74  ? 375 GLU B OE1 1 
ATOM   6848  O OE2 . GLU B 1 375 ? 0.641   66.902  -16.326 1.00 58.49  ? 375 GLU B OE2 1 
ATOM   6849  N N   . ASN B 1 376 ? 3.574   68.055  -21.546 1.00 51.06  ? 376 ASN B N   1 
ATOM   6850  C CA  . ASN B 1 376 ? 4.327   69.299  -21.491 1.00 50.07  ? 376 ASN B CA  1 
ATOM   6851  C C   . ASN B 1 376 ? 4.781   69.824  -22.864 1.00 51.61  ? 376 ASN B C   1 
ATOM   6852  O O   . ASN B 1 376 ? 5.080   71.015  -22.954 1.00 48.09  ? 376 ASN B O   1 
ATOM   6853  C CB  . ASN B 1 376 ? 5.461   69.154  -20.484 1.00 52.42  ? 376 ASN B CB  1 
ATOM   6854  C CG  . ASN B 1 376 ? 4.918   69.016  -19.074 1.00 55.91  ? 376 ASN B CG  1 
ATOM   6855  O OD1 . ASN B 1 376 ? 4.356   69.979  -18.534 1.00 46.18  ? 376 ASN B OD1 1 
ATOM   6856  N ND2 . ASN B 1 376 ? 5.050   67.842  -18.463 1.00 54.90  ? 376 ASN B ND2 1 
ATOM   6857  N N   . ILE B 1 377 ? 4.766   69.002  -23.934 1.00 43.31  ? 377 ILE B N   1 
ATOM   6858  C CA  . ILE B 1 377 ? 5.326   69.379  -25.232 1.00 43.12  ? 377 ILE B CA  1 
ATOM   6859  C C   . ILE B 1 377 ? 4.664   70.629  -25.819 1.00 39.23  ? 377 ILE B C   1 
ATOM   6860  O O   . ILE B 1 377 ? 5.334   71.445  -26.433 1.00 47.82  ? 377 ILE B O   1 
ATOM   6861  C CB  . ILE B 1 377 ? 5.305   68.226  -26.273 1.00 44.22  ? 377 ILE B CB  1 
ATOM   6862  C CG1 . ILE B 1 377 ? 6.066   68.598  -27.581 1.00 49.05  ? 377 ILE B CG1 1 
ATOM   6863  C CG2 . ILE B 1 377 ? 3.896   67.753  -26.628 1.00 39.90  ? 377 ILE B CG2 1 
ATOM   6864  C CD1 . ILE B 1 377 ? 7.558   68.873  -27.409 1.00 49.84  ? 377 ILE B CD1 1 
ATOM   6865  N N   . HIS B 1 378 ? 3.346   70.751  -25.733 1.00 42.65  ? 378 HIS B N   1 
ATOM   6866  C CA  . HIS B 1 378 ? 2.685   71.912  -26.309 1.00 47.92  ? 378 HIS B CA  1 
ATOM   6867  C C   . HIS B 1 378 ? 3.191   73.188  -25.628 1.00 51.60  ? 378 HIS B C   1 
ATOM   6868  O O   . HIS B 1 378 ? 3.253   74.227  -26.281 1.00 47.75  ? 378 HIS B O   1 
ATOM   6869  C CB  . HIS B 1 378 ? 1.158   71.763  -26.314 1.00 44.29  ? 378 HIS B CB  1 
ATOM   6870  C CG  . HIS B 1 378 ? 0.513   71.916  -24.982 1.00 52.65  ? 378 HIS B CG  1 
ATOM   6871  N ND1 . HIS B 1 378 ? 0.510   70.923  -24.017 1.00 59.27  ? 378 HIS B ND1 1 
ATOM   6872  C CD2 . HIS B 1 378 ? -0.168  72.941  -24.462 1.00 55.41  ? 378 HIS B CD2 1 
ATOM   6873  C CE1 . HIS B 1 378 ? -0.153  71.343  -22.957 1.00 53.05  ? 378 HIS B CE1 1 
ATOM   6874  N NE2 . HIS B 1 378 ? -0.569  72.573  -23.203 1.00 56.32  ? 378 HIS B NE2 1 
ATOM   6875  N N   . ASN B 1 379 ? 3.595   73.088  -24.345 1.00 53.28  ? 379 ASN B N   1 
ATOM   6876  C CA  . ASN B 1 379 ? 4.092   74.240  -23.602 1.00 51.38  ? 379 ASN B CA  1 
ATOM   6877  C C   . ASN B 1 379 ? 5.523   74.573  -24.042 1.00 49.71  ? 379 ASN B C   1 
ATOM   6878  O O   . ASN B 1 379 ? 5.897   75.754  -24.141 1.00 44.27  ? 379 ASN B O   1 
ATOM   6879  C CB  . ASN B 1 379 ? 3.942   74.086  -22.085 1.00 47.95  ? 379 ASN B CB  1 
ATOM   6880  C CG  . ASN B 1 379 ? 2.507   74.168  -21.606 1.00 55.03  ? 379 ASN B CG  1 
ATOM   6881  O OD1 . ASN B 1 379 ? 1.725   75.001  -22.071 1.00 59.60  ? 379 ASN B OD1 1 
ATOM   6882  N ND2 . ASN B 1 379 ? 2.115   73.283  -20.700 1.00 63.61  ? 379 ASN B ND2 1 
ATOM   6883  N N   . ALA B 1 380 ? 6.341   73.554  -24.318 1.00 53.48  ? 380 ALA B N   1 
ATOM   6884  C CA  . ALA B 1 380 ? 7.722   73.825  -24.715 1.00 55.82  ? 380 ALA B CA  1 
ATOM   6885  C C   . ALA B 1 380 ? 7.762   74.420  -26.129 1.00 51.76  ? 380 ALA B C   1 
ATOM   6886  O O   . ALA B 1 380 ? 8.535   75.340  -26.385 1.00 53.09  ? 380 ALA B O   1 
ATOM   6887  C CB  . ALA B 1 380 ? 8.574   72.587  -24.593 1.00 52.84  ? 380 ALA B CB  1 
ATOM   6888  N N   . VAL B 1 381 ? 6.900   73.927  -27.028 1.00 46.02  ? 381 VAL B N   1 
ATOM   6889  C CA  . VAL B 1 381 ? 6.768   74.493  -28.363 1.00 51.24  ? 381 VAL B CA  1 
ATOM   6890  C C   . VAL B 1 381 ? 6.225   75.929  -28.268 1.00 55.62  ? 381 VAL B C   1 
ATOM   6891  O O   . VAL B 1 381 ? 6.730   76.847  -28.938 1.00 45.22  ? 381 VAL B O   1 
ATOM   6892  C CB  . VAL B 1 381 ? 5.877   73.577  -29.229 1.00 53.95  ? 381 VAL B CB  1 
ATOM   6893  C CG1 . VAL B 1 381 ? 5.449   74.229  -30.550 1.00 48.36  ? 381 VAL B CG1 1 
ATOM   6894  C CG2 . VAL B 1 381 ? 6.578   72.250  -29.497 1.00 56.93  ? 381 VAL B CG2 1 
ATOM   6895  N N   . ASN B 1 382 ? 5.206   76.116  -27.413 1.00 50.68  ? 382 ASN B N   1 
ATOM   6896  C CA  . ASN B 1 382 ? 4.584   77.415  -27.219 1.00 53.80  ? 382 ASN B CA  1 
ATOM   6897  C C   . ASN B 1 382 ? 5.615   78.434  -26.731 1.00 53.98  ? 382 ASN B C   1 
ATOM   6898  O O   . ASN B 1 382 ? 5.638   79.558  -27.232 1.00 59.44  ? 382 ASN B O   1 
ATOM   6899  C CB  . ASN B 1 382 ? 3.377   77.342  -26.292 1.00 54.79  ? 382 ASN B CB  1 
ATOM   6900  C CG  . ASN B 1 382 ? 2.710   78.692  -26.176 1.00 56.78  ? 382 ASN B CG  1 
ATOM   6901  O OD1 . ASN B 1 382 ? 2.965   79.439  -25.221 1.00 56.29  ? 382 ASN B OD1 1 
ATOM   6902  N ND2 . ASN B 1 382 ? 1.877   79.028  -27.146 1.00 56.63  ? 382 ASN B ND2 1 
ATOM   6903  N N   . GLN B 1 383 ? 6.472   78.022  -25.788 1.00 52.18  ? 383 GLN B N   1 
ATOM   6904  C CA  . GLN B 1 383 ? 7.530   78.871  -25.254 1.00 51.38  ? 383 GLN B CA  1 
ATOM   6905  C C   . GLN B 1 383 ? 8.530   79.228  -26.358 1.00 53.44  ? 383 GLN B C   1 
ATOM   6906  O O   . GLN B 1 383 ? 8.961   80.367  -26.462 1.00 53.63  ? 383 GLN B O   1 
ATOM   6907  C CB  . GLN B 1 383 ? 8.169   78.175  -24.046 1.00 50.25  ? 383 GLN B CB  1 
ATOM   6908  C CG  . GLN B 1 383 ? 9.213   79.006  -23.305 1.00 50.69  ? 383 GLN B CG  1 
ATOM   6909  C CD  . GLN B 1 383 ? 8.699   80.365  -22.879 1.00 54.47  ? 383 GLN B CD  1 
ATOM   6910  O OE1 . GLN B 1 383 ? 8.911   81.376  -23.560 1.00 55.32  ? 383 GLN B OE1 1 
ATOM   6911  N NE2 . GLN B 1 383 ? 7.953   80.387  -21.787 1.00 54.56  ? 383 GLN B NE2 1 
ATOM   6912  N N   . LEU B 1 384 ? 8.880   78.275  -27.227 1.00 54.57  ? 384 LEU B N   1 
ATOM   6913  C CA  . LEU B 1 384 ? 9.845   78.556  -28.277 1.00 52.00  ? 384 LEU B CA  1 
ATOM   6914  C C   . LEU B 1 384 ? 9.308   79.681  -29.168 1.00 56.17  ? 384 LEU B C   1 
ATOM   6915  O O   . LEU B 1 384 ? 10.037  80.625  -29.486 1.00 48.92  ? 384 LEU B O   1 
ATOM   6916  C CB  . LEU B 1 384 ? 10.119  77.274  -29.068 1.00 52.64  ? 384 LEU B CB  1 
ATOM   6917  C CG  . LEU B 1 384 ? 11.118  77.374  -30.228 1.00 50.17  ? 384 LEU B CG  1 
ATOM   6918  C CD1 . LEU B 1 384 ? 12.534  77.696  -29.761 1.00 50.91  ? 384 LEU B CD1 1 
ATOM   6919  C CD2 . LEU B 1 384 ? 11.106  76.078  -31.047 1.00 54.94  ? 384 LEU B CD2 1 
ATOM   6920  N N   . ILE B 1 385 ? 8.039   79.538  -29.587 1.00 50.79  ? 385 ILE B N   1 
ATOM   6921  C CA  . ILE B 1 385 ? 7.367   80.521  -30.417 1.00 53.93  ? 385 ILE B CA  1 
ATOM   6922  C C   . ILE B 1 385 ? 7.377   81.891  -29.716 1.00 55.74  ? 385 ILE B C   1 
ATOM   6923  O O   . ILE B 1 385 ? 7.665   82.905  -30.343 1.00 53.23  ? 385 ILE B O   1 
ATOM   6924  C CB  . ILE B 1 385 ? 5.950   80.028  -30.781 1.00 63.94  ? 385 ILE B CB  1 
ATOM   6925  C CG1 . ILE B 1 385 ? 5.928   79.100  -32.026 1.00 70.22  ? 385 ILE B CG1 1 
ATOM   6926  C CG2 . ILE B 1 385 ? 4.993   81.197  -31.006 1.00 62.68  ? 385 ILE B CG2 1 
ATOM   6927  C CD1 . ILE B 1 385 ? 6.837   77.885  -31.973 1.00 72.05  ? 385 ILE B CD1 1 
ATOM   6928  N N   . GLU B 1 386 ? 7.101   81.945  -28.407 1.00 57.04  ? 386 GLU B N   1 
ATOM   6929  C CA  . GLU B 1 386 ? 7.106   83.221  -27.702 1.00 58.65  ? 386 GLU B CA  1 
ATOM   6930  C C   . GLU B 1 386 ? 8.456   83.922  -27.889 1.00 61.72  ? 386 GLU B C   1 
ATOM   6931  O O   . GLU B 1 386 ? 8.522   85.143  -28.079 1.00 59.51  ? 386 GLU B O   1 
ATOM   6932  C CB  . GLU B 1 386 ? 6.789   83.083  -26.213 1.00 63.38  ? 386 GLU B CB  1 
ATOM   6933  C CG  . GLU B 1 386 ? 5.402   82.510  -25.927 1.00 70.55  ? 386 GLU B CG  1 
ATOM   6934  C CD  . GLU B 1 386 ? 4.272   83.487  -25.681 1.00 78.70  ? 386 GLU B CD  1 
ATOM   6935  O OE1 . GLU B 1 386 ? 4.432   84.721  -25.834 1.00 85.97  ? 386 GLU B OE1 1 
ATOM   6936  O OE2 . GLU B 1 386 ? 3.200   82.962  -25.307 1.00 91.14  ? 386 GLU B OE2 1 
ATOM   6937  N N   . PHE B 1 387 ? 9.543   83.146  -27.850 1.00 53.13  ? 387 PHE B N   1 
ATOM   6938  C CA  . PHE B 1 387 ? 10.871  83.716  -27.987 1.00 51.14  ? 387 PHE B CA  1 
ATOM   6939  C C   . PHE B 1 387 ? 11.022  84.409  -29.340 1.00 51.24  ? 387 PHE B C   1 
ATOM   6940  O O   . PHE B 1 387 ? 11.784  85.369  -29.447 1.00 49.72  ? 387 PHE B O   1 
ATOM   6941  C CB  . PHE B 1 387 ? 11.958  82.649  -27.823 1.00 54.41  ? 387 PHE B CB  1 
ATOM   6942  C CG  . PHE B 1 387 ? 12.156  82.100  -26.413 1.00 53.00  ? 387 PHE B CG  1 
ATOM   6943  C CD1 . PHE B 1 387 ? 12.006  82.919  -25.291 1.00 51.64  ? 387 PHE B CD1 1 
ATOM   6944  C CD2 . PHE B 1 387 ? 12.494  80.761  -26.219 1.00 45.82  ? 387 PHE B CD2 1 
ATOM   6945  C CE1 . PHE B 1 387 ? 12.199  82.415  -24.017 1.00 52.01  ? 387 PHE B CE1 1 
ATOM   6946  C CE2 . PHE B 1 387 ? 12.671  80.264  -24.942 1.00 49.96  ? 387 PHE B CE2 1 
ATOM   6947  C CZ  . PHE B 1 387 ? 12.528  81.088  -23.845 1.00 52.85  ? 387 PHE B CZ  1 
ATOM   6948  N N   . CYS B 1 388 ? 10.311  83.931  -30.371 1.00 52.76  ? 388 CYS B N   1 
ATOM   6949  C CA  . CYS B 1 388 ? 10.471  84.496  -31.706 1.00 63.47  ? 388 CYS B CA  1 
ATOM   6950  C C   . CYS B 1 388 ? 9.946   85.931  -31.789 1.00 67.09  ? 388 CYS B C   1 
ATOM   6951  O O   . CYS B 1 388 ? 10.531  86.773  -32.463 1.00 62.96  ? 388 CYS B O   1 
ATOM   6952  C CB  . CYS B 1 388 ? 9.777   83.654  -32.765 1.00 62.83  ? 388 CYS B CB  1 
ATOM   6953  S SG  . CYS B 1 388 ? 10.452  81.979  -32.888 1.00 67.47  ? 388 CYS B SG  1 
ATOM   6954  N N   . GLY B 1 389 ? 8.829   86.205  -31.113 1.00 72.05  ? 389 GLY B N   1 
ATOM   6955  C CA  . GLY B 1 389 ? 8.108   87.445  -31.340 1.00 70.66  ? 389 GLY B CA  1 
ATOM   6956  C C   . GLY B 1 389 ? 7.556   87.462  -32.760 1.00 72.96  ? 389 GLY B C   1 
ATOM   6957  O O   . GLY B 1 389 ? 7.235   86.407  -33.308 1.00 66.39  ? 389 GLY B O   1 
ATOM   6958  N N   . ARG B 1 390 ? 7.540   88.659  -33.362 1.00 80.35  ? 390 ARG B N   1 
ATOM   6959  C CA  . ARG B 1 390 ? 6.825   88.908  -34.606 1.00 78.13  ? 390 ARG B CA  1 
ATOM   6960  C C   . ARG B 1 390 ? 7.527   88.254  -35.801 1.00 75.15  ? 390 ARG B C   1 
ATOM   6961  O O   . ARG B 1 390 ? 6.866   87.908  -36.770 1.00 68.98  ? 390 ARG B O   1 
ATOM   6962  C CB  . ARG B 1 390 ? 6.534   90.404  -34.782 1.00 87.36  ? 390 ARG B CB  1 
ATOM   6963  C CG  . ARG B 1 390 ? 7.512   91.370  -34.125 1.00 101.36 ? 390 ARG B CG  1 
ATOM   6964  C CD  . ARG B 1 390 ? 7.267   92.811  -34.538 1.00 105.35 ? 390 ARG B CD  1 
ATOM   6965  N NE  . ARG B 1 390 ? 8.532   93.548  -34.440 1.00 111.73 ? 390 ARG B NE  1 
ATOM   6966  C CZ  . ARG B 1 390 ? 9.428   93.696  -35.423 1.00 109.52 ? 390 ARG B CZ  1 
ATOM   6967  N NH1 . ARG B 1 390 ? 9.280   93.076  -36.589 1.00 98.73  ? 390 ARG B NH1 1 
ATOM   6968  N NH2 . ARG B 1 390 ? 10.487  94.466  -35.223 1.00 104.27 ? 390 ARG B NH2 1 
ATOM   6969  N N   . GLY B 1 391 ? 8.842   88.011  -35.722 1.00 81.58  ? 391 GLY B N   1 
ATOM   6970  C CA  . GLY B 1 391 ? 9.574   87.321  -36.781 1.00 76.71  ? 391 GLY B CA  1 
ATOM   6971  C C   . GLY B 1 391 ? 8.837   86.110  -37.366 1.00 78.06  ? 391 GLY B C   1 
ATOM   6972  O O   . GLY B 1 391 ? 9.098   85.730  -38.502 1.00 77.43  ? 391 GLY B O   1 
ATOM   6973  N N   . VAL B 1 392 ? 7.918   85.505  -36.600 1.00 85.86  ? 392 VAL B N   1 
ATOM   6974  C CA  . VAL B 1 392 ? 7.166   84.326  -37.023 1.00 88.04  ? 392 VAL B CA  1 
ATOM   6975  C C   . VAL B 1 392 ? 5.880   84.706  -37.770 1.00 85.37  ? 392 VAL B C   1 
ATOM   6976  O O   . VAL B 1 392 ? 5.303   83.868  -38.452 1.00 86.76  ? 392 VAL B O   1 
ATOM   6977  C CB  . VAL B 1 392 ? 6.902   83.424  -35.790 1.00 80.29  ? 392 VAL B CB  1 
ATOM   6978  C CG1 . VAL B 1 392 ? 5.449   82.963  -35.627 1.00 72.72  ? 392 VAL B CG1 1 
ATOM   6979  C CG2 . VAL B 1 392 ? 7.854   82.238  -35.771 1.00 64.40  ? 392 VAL B CG2 1 
ATOM   6980  N N   . VAL B 1 393 ? 5.419   85.956  -37.642 1.00 103.69 ? 393 VAL B N   1 
ATOM   6981  C CA  . VAL B 1 393 ? 4.250   86.430  -38.376 1.00 108.22 ? 393 VAL B CA  1 
ATOM   6982  C C   . VAL B 1 393 ? 4.685   86.735  -39.812 1.00 103.32 ? 393 VAL B C   1 
ATOM   6983  O O   . VAL B 1 393 ? 4.119   86.199  -40.765 1.00 102.44 ? 393 VAL B O   1 
ATOM   6984  C CB  . VAL B 1 393 ? 3.559   87.656  -37.729 1.00 111.62 ? 393 VAL B CB  1 
ATOM   6985  C CG1 . VAL B 1 393 ? 2.288   88.070  -38.471 1.00 113.77 ? 393 VAL B CG1 1 
ATOM   6986  C CG2 . VAL B 1 393 ? 3.239   87.444  -36.250 1.00 111.97 ? 393 VAL B CG2 1 
ATOM   6987  N N   . MET B 1 394 ? 5.686   87.615  -39.952 1.00 87.75  ? 394 MET B N   1 
ATOM   6988  C CA  . MET B 1 394 ? 6.246   87.949  -41.249 1.00 87.79  ? 394 MET B CA  1 
ATOM   6989  C C   . MET B 1 394 ? 7.751   87.721  -41.171 1.00 77.38  ? 394 MET B C   1 
ATOM   6990  O O   . MET B 1 394 ? 8.440   88.350  -40.379 1.00 83.45  ? 394 MET B O   1 
ATOM   6991  C CB  . MET B 1 394 ? 5.924   89.396  -41.657 1.00 98.64  ? 394 MET B CB  1 
ATOM   6992  C CG  . MET B 1 394 ? 6.195   89.736  -43.142 1.00 103.23 ? 394 MET B CG  1 
ATOM   6993  S SD  . MET B 1 394 ? 7.915   89.985  -43.652 1.00 100.82 ? 394 MET B SD  1 
ATOM   6994  C CE  . MET B 1 394 ? 7.879   90.091  -45.447 1.00 78.32  ? 394 MET B CE  1 
ATOM   6995  N N   . SER B 1 395 ? 8.214   86.745  -41.948 1.00 72.70  ? 395 SER B N   1 
ATOM   6996  C CA  . SER B 1 395 ? 9.615   86.560  -42.268 1.00 67.39  ? 395 SER B CA  1 
ATOM   6997  C C   . SER B 1 395 ? 9.741   86.532  -43.787 1.00 62.07  ? 395 SER B C   1 
ATOM   6998  O O   . SER B 1 395 ? 8.993   85.805  -44.448 1.00 56.17  ? 395 SER B O   1 
ATOM   6999  C CB  . SER B 1 395 ? 10.171  85.309  -41.640 1.00 71.06  ? 395 SER B CB  1 
ATOM   7000  O OG  . SER B 1 395 ? 10.750  85.600  -40.375 1.00 73.31  ? 395 SER B OG  1 
ATOM   7001  N N   . PRO B 1 396 ? 10.646  87.354  -44.377 1.00 67.93  ? 396 PRO B N   1 
ATOM   7002  C CA  . PRO B 1 396 ? 10.776  87.458  -45.842 1.00 65.51  ? 396 PRO B CA  1 
ATOM   7003  C C   . PRO B 1 396 ? 11.201  86.156  -46.523 1.00 60.94  ? 396 PRO B C   1 
ATOM   7004  O O   . PRO B 1 396 ? 11.977  85.390  -45.960 1.00 55.55  ? 396 PRO B O   1 
ATOM   7005  C CB  . PRO B 1 396 ? 11.822  88.564  -46.056 1.00 67.60  ? 396 PRO B CB  1 
ATOM   7006  C CG  . PRO B 1 396 ? 11.904  89.282  -44.719 1.00 70.52  ? 396 PRO B CG  1 
ATOM   7007  C CD  . PRO B 1 396 ? 11.559  88.259  -43.661 1.00 62.50  ? 396 PRO B CD  1 
ATOM   7008  N N   . THR B 1 397 ? 10.675  85.918  -47.735 1.00 63.01  ? 397 THR B N   1 
ATOM   7009  C CA  . THR B 1 397 ? 11.075  84.788  -48.564 1.00 55.57  ? 397 THR B CA  1 
ATOM   7010  C C   . THR B 1 397 ? 12.470  85.054  -49.121 1.00 58.08  ? 397 THR B C   1 
ATOM   7011  O O   . THR B 1 397 ? 13.041  86.122  -48.898 1.00 55.06  ? 397 THR B O   1 
ATOM   7012  C CB  . THR B 1 397 ? 10.073  84.540  -49.696 1.00 50.57  ? 397 THR B CB  1 
ATOM   7013  O OG1 . THR B 1 397 ? 10.052  85.660  -50.589 1.00 45.85  ? 397 THR B OG1 1 
ATOM   7014  C CG2 . THR B 1 397 ? 8.680   84.234  -49.169 1.00 46.45  ? 397 THR B CG2 1 
ATOM   7015  N N   . LYS B 1 398 ? 13.004  84.060  -49.842 1.00 62.16  ? 398 LYS B N   1 
ATOM   7016  C CA  . LYS B 1 398 ? 14.275  84.207  -50.531 1.00 63.00  ? 398 LYS B CA  1 
ATOM   7017  C C   . LYS B 1 398 ? 14.107  85.261  -51.634 1.00 56.35  ? 398 LYS B C   1 
ATOM   7018  O O   . LYS B 1 398 ? 15.002  86.090  -51.822 1.00 54.07  ? 398 LYS B O   1 
ATOM   7019  C CB  . LYS B 1 398 ? 14.846  82.862  -51.015 1.00 61.45  ? 398 LYS B CB  1 
ATOM   7020  C CG  . LYS B 1 398 ? 16.226  83.021  -51.671 1.00 68.20  ? 398 LYS B CG  1 
ATOM   7021  C CD  . LYS B 1 398 ? 17.162  81.814  -51.730 1.00 77.23  ? 398 LYS B CD  1 
ATOM   7022  C CE  . LYS B 1 398 ? 18.585  82.141  -52.155 1.00 70.38  ? 398 LYS B CE  1 
ATOM   7023  N NZ  . LYS B 1 398 ? 18.670  82.766  -53.485 1.00 62.70  ? 398 LYS B NZ  1 
ATOM   7024  N N   . ALA B 1 399 ? 12.945  85.224  -52.320 1.00 53.09  ? 399 ALA B N   1 
ATOM   7025  C CA  . ALA B 1 399 ? 12.597  86.156  -53.384 1.00 56.20  ? 399 ALA B CA  1 
ATOM   7026  C C   . ALA B 1 399 ? 12.646  87.604  -52.869 1.00 59.90  ? 399 ALA B C   1 
ATOM   7027  O O   . ALA B 1 399 ? 13.264  88.441  -53.525 1.00 65.58  ? 399 ALA B O   1 
ATOM   7028  C CB  . ALA B 1 399 ? 11.239  85.802  -53.970 1.00 51.94  ? 399 ALA B CB  1 
ATOM   7029  N N   . ASP B 1 400 ? 12.066  87.869  -51.677 1.00 56.31  ? 400 ASP B N   1 
ATOM   7030  C CA  . ASP B 1 400 ? 12.114  89.175  -51.008 1.00 55.01  ? 400 ASP B CA  1 
ATOM   7031  C C   . ASP B 1 400 ? 13.561  89.642  -50.794 1.00 52.12  ? 400 ASP B C   1 
ATOM   7032  O O   . ASP B 1 400 ? 13.892  90.781  -51.111 1.00 56.48  ? 400 ASP B O   1 
ATOM   7033  C CB  . ASP B 1 400 ? 11.387  89.204  -49.661 1.00 47.60  ? 400 ASP B CB  1 
ATOM   7034  C CG  . ASP B 1 400 ? 9.885   88.939  -49.669 1.00 51.48  ? 400 ASP B CG  1 
ATOM   7035  O OD1 . ASP B 1 400 ? 9.180   89.619  -50.422 1.00 48.39  ? 400 ASP B OD1 1 
ATOM   7036  O OD2 . ASP B 1 400 ? 9.406   88.053  -48.900 1.00 60.90  ? 400 ASP B OD2 1 
ATOM   7037  N N   . PHE B 1 401 ? 14.416  88.771  -50.237 1.00 53.66  ? 401 PHE B N   1 
ATOM   7038  C CA  . PHE B 1 401 ? 15.825  89.079  -50.020 1.00 58.24  ? 401 PHE B CA  1 
ATOM   7039  C C   . PHE B 1 401 ? 16.577  89.192  -51.353 1.00 57.25  ? 401 PHE B C   1 
ATOM   7040  O O   . PHE B 1 401 ? 17.575  89.893  -51.416 1.00 58.42  ? 401 PHE B O   1 
ATOM   7041  C CB  . PHE B 1 401 ? 16.540  88.035  -49.150 1.00 58.99  ? 401 PHE B CB  1 
ATOM   7042  C CG  . PHE B 1 401 ? 16.349  88.120  -47.640 1.00 61.67  ? 401 PHE B CG  1 
ATOM   7043  C CD1 . PHE B 1 401 ? 16.575  89.309  -46.946 1.00 63.61  ? 401 PHE B CD1 1 
ATOM   7044  C CD2 . PHE B 1 401 ? 15.946  87.001  -46.909 1.00 61.51  ? 401 PHE B CD2 1 
ATOM   7045  C CE1 . PHE B 1 401 ? 16.403  89.374  -45.565 1.00 63.99  ? 401 PHE B CE1 1 
ATOM   7046  C CE2 . PHE B 1 401 ? 15.763  87.073  -45.535 1.00 60.04  ? 401 PHE B CE2 1 
ATOM   7047  C CZ  . PHE B 1 401 ? 16.010  88.253  -44.859 1.00 60.13  ? 401 PHE B CZ  1 
ATOM   7048  N N   . ASP B 1 402 ? 16.116  88.524  -52.417 1.00 58.11  ? 402 ASP B N   1 
ATOM   7049  C CA  . ASP B 1 402 ? 16.772  88.626  -53.717 1.00 64.90  ? 402 ASP B CA  1 
ATOM   7050  C C   . ASP B 1 402 ? 16.342  89.861  -54.535 1.00 65.32  ? 402 ASP B C   1 
ATOM   7051  O O   . ASP B 1 402 ? 16.938  90.113  -55.583 1.00 61.54  ? 402 ASP B O   1 
ATOM   7052  C CB  . ASP B 1 402 ? 16.591  87.346  -54.524 1.00 60.99  ? 402 ASP B CB  1 
ATOM   7053  C CG  . ASP B 1 402 ? 17.340  86.123  -54.013 1.00 59.51  ? 402 ASP B CG  1 
ATOM   7054  O OD1 . ASP B 1 402 ? 18.169  86.280  -53.087 1.00 59.40  ? 402 ASP B OD1 1 
ATOM   7055  O OD2 . ASP B 1 402 ? 17.066  85.014  -54.525 1.00 62.66  ? 402 ASP B OD2 1 
ATOM   7056  N N   . HIS B 1 403 ? 15.321  90.631  -54.113 1.00 64.33  ? 403 HIS B N   1 
ATOM   7057  C CA  . HIS B 1 403 ? 14.917  91.830  -54.851 1.00 67.17  ? 403 HIS B CA  1 
ATOM   7058  C C   . HIS B 1 403 ? 16.127  92.752  -55.036 1.00 65.08  ? 403 HIS B C   1 
ATOM   7059  O O   . HIS B 1 403 ? 16.849  93.000  -54.071 1.00 65.77  ? 403 HIS B O   1 
ATOM   7060  C CB  . HIS B 1 403 ? 13.775  92.580  -54.147 1.00 65.85  ? 403 HIS B CB  1 
ATOM   7061  C CG  . HIS B 1 403 ? 13.011  93.553  -55.001 1.00 69.01  ? 403 HIS B CG  1 
ATOM   7062  N ND1 . HIS B 1 403 ? 13.476  94.800  -55.372 1.00 66.52  ? 403 HIS B ND1 1 
ATOM   7063  C CD2 . HIS B 1 403 ? 11.786  93.441  -55.552 1.00 66.50  ? 403 HIS B CD2 1 
ATOM   7064  C CE1 . HIS B 1 403 ? 12.562  95.401  -56.122 1.00 65.30  ? 403 HIS B CE1 1 
ATOM   7065  N NE2 . HIS B 1 403 ? 11.532  94.591  -56.256 1.00 65.87  ? 403 HIS B NE2 1 
ATOM   7066  N N   . PRO B 1 404 ? 16.400  93.274  -56.262 1.00 72.45  ? 404 PRO B N   1 
ATOM   7067  C CA  . PRO B 1 404 ? 17.582  94.112  -56.519 1.00 70.88  ? 404 PRO B CA  1 
ATOM   7068  C C   . PRO B 1 404 ? 17.743  95.334  -55.612 1.00 68.53  ? 404 PRO B C   1 
ATOM   7069  O O   . PRO B 1 404 ? 18.870  95.653  -55.214 1.00 61.92  ? 404 PRO B O   1 
ATOM   7070  C CB  . PRO B 1 404 ? 17.408  94.554  -57.989 1.00 72.73  ? 404 PRO B CB  1 
ATOM   7071  C CG  . PRO B 1 404 ? 16.525  93.490  -58.596 1.00 77.69  ? 404 PRO B CG  1 
ATOM   7072  C CD  . PRO B 1 404 ? 15.583  93.083  -57.475 1.00 78.85  ? 404 PRO B CD  1 
ATOM   7073  N N   . PHE B 1 405 ? 16.613  95.999  -55.299 1.00 57.94  ? 405 PHE B N   1 
ATOM   7074  C CA  . PHE B 1 405 ? 16.612  97.250  -54.550 1.00 64.69  ? 405 PHE B CA  1 
ATOM   7075  C C   . PHE B 1 405 ? 16.202  97.041  -53.086 1.00 66.92  ? 405 PHE B C   1 
ATOM   7076  O O   . PHE B 1 405 ? 16.914  97.487  -52.184 1.00 61.15  ? 405 PHE B O   1 
ATOM   7077  C CB  . PHE B 1 405 ? 15.690  98.264  -55.240 1.00 68.72  ? 405 PHE B CB  1 
ATOM   7078  C CG  . PHE B 1 405 ? 15.526  99.589  -54.503 1.00 75.65  ? 405 PHE B CG  1 
ATOM   7079  C CD1 . PHE B 1 405 ? 16.540  100.550 -54.534 1.00 79.66  ? 405 PHE B CD1 1 
ATOM   7080  C CD2 . PHE B 1 405 ? 14.354  99.873  -53.794 1.00 72.89  ? 405 PHE B CD2 1 
ATOM   7081  C CE1 . PHE B 1 405 ? 16.390  101.757 -53.862 1.00 81.87  ? 405 PHE B CE1 1 
ATOM   7082  C CE2 . PHE B 1 405 ? 14.206  101.080 -53.124 1.00 75.05  ? 405 PHE B CE2 1 
ATOM   7083  C CZ  . PHE B 1 405 ? 15.226  102.018 -53.156 1.00 82.73  ? 405 PHE B CZ  1 
ATOM   7084  N N   . LEU B 1 406 ? 15.033  96.412  -52.854 1.00 67.10  ? 406 LEU B N   1 
ATOM   7085  C CA  . LEU B 1 406 ? 14.458  96.296  -51.517 1.00 59.12  ? 406 LEU B CA  1 
ATOM   7086  C C   . LEU B 1 406 ? 15.164  95.204  -50.724 1.00 58.39  ? 406 LEU B C   1 
ATOM   7087  O O   . LEU B 1 406 ? 15.092  95.208  -49.500 1.00 57.92  ? 406 LEU B O   1 
ATOM   7088  C CB  . LEU B 1 406 ? 12.961  95.998  -51.557 1.00 56.35  ? 406 LEU B CB  1 
ATOM   7089  C CG  . LEU B 1 406 ? 12.061  97.097  -52.121 1.00 60.39  ? 406 LEU B CG  1 
ATOM   7090  C CD1 . LEU B 1 406 ? 10.678  96.530  -52.440 1.00 58.84  ? 406 LEU B CD1 1 
ATOM   7091  C CD2 . LEU B 1 406 ? 11.983  98.304  -51.172 1.00 61.90  ? 406 LEU B CD2 1 
ATOM   7092  N N   . GLY B 1 407 ? 15.786  94.251  -51.435 1.00 58.22  ? 407 GLY B N   1 
ATOM   7093  C CA  . GLY B 1 407 ? 16.319  93.045  -50.827 1.00 52.78  ? 407 GLY B CA  1 
ATOM   7094  C C   . GLY B 1 407 ? 17.547  93.337  -49.977 1.00 53.49  ? 407 GLY B C   1 
ATOM   7095  O O   . GLY B 1 407 ? 17.678  92.812  -48.874 1.00 57.91  ? 407 GLY B O   1 
ATOM   7096  N N   . PRO B 1 408 ? 18.523  94.125  -50.471 1.00 54.67  ? 408 PRO B N   1 
ATOM   7097  C CA  . PRO B 1 408 ? 19.609  94.594  -49.604 1.00 56.94  ? 408 PRO B CA  1 
ATOM   7098  C C   . PRO B 1 408 ? 19.108  95.474  -48.451 1.00 60.25  ? 408 PRO B C   1 
ATOM   7099  O O   . PRO B 1 408 ? 19.735  95.501  -47.389 1.00 53.93  ? 408 PRO B O   1 
ATOM   7100  C CB  . PRO B 1 408 ? 20.586  95.320  -50.552 1.00 52.19  ? 408 PRO B CB  1 
ATOM   7101  C CG  . PRO B 1 408 ? 20.204  94.846  -51.950 1.00 49.20  ? 408 PRO B CG  1 
ATOM   7102  C CD  . PRO B 1 408 ? 18.721  94.467  -51.891 1.00 54.47  ? 408 PRO B CD  1 
ATOM   7103  N N   . LYS B 1 409 ? 17.946  96.131  -48.635 1.00 57.40  ? 409 LYS B N   1 
ATOM   7104  C CA  . LYS B 1 409 ? 17.328  96.932  -47.586 1.00 62.74  ? 409 LYS B CA  1 
ATOM   7105  C C   . LYS B 1 409 ? 16.821  96.035  -46.457 1.00 60.73  ? 409 LYS B C   1 
ATOM   7106  O O   . LYS B 1 409 ? 16.862  96.433  -45.298 1.00 53.68  ? 409 LYS B O   1 
ATOM   7107  C CB  . LYS B 1 409 ? 16.188  97.809  -48.119 1.00 71.64  ? 409 LYS B CB  1 
ATOM   7108  C CG  . LYS B 1 409 ? 16.574  98.886  -49.132 1.00 80.42  ? 409 LYS B CG  1 
ATOM   7109  C CD  . LYS B 1 409 ? 17.243  100.131 -48.561 1.00 89.37  ? 409 LYS B CD  1 
ATOM   7110  C CE  . LYS B 1 409 ? 17.270  101.268 -49.548 1.00 91.82  ? 409 LYS B CE  1 
ATOM   7111  N NZ  . LYS B 1 409 ? 17.991  100.944 -50.778 1.00 96.45  ? 409 LYS B NZ  1 
ATOM   7112  N N   . LEU B 1 410 ? 16.334  94.830  -46.796 1.00 66.07  ? 410 LEU B N   1 
ATOM   7113  C CA  . LEU B 1 410 ? 15.879  93.857  -45.804 1.00 65.25  ? 410 LEU B CA  1 
ATOM   7114  C C   . LEU B 1 410 ? 17.070  93.262  -45.056 1.00 62.07  ? 410 LEU B C   1 
ATOM   7115  O O   . LEU B 1 410 ? 17.018  93.119  -43.837 1.00 58.14  ? 410 LEU B O   1 
ATOM   7116  C CB  . LEU B 1 410 ? 15.054  92.744  -46.441 1.00 61.48  ? 410 LEU B CB  1 
ATOM   7117  C CG  . LEU B 1 410 ? 13.579  93.059  -46.671 1.00 62.88  ? 410 LEU B CG  1 
ATOM   7118  C CD1 . LEU B 1 410 ? 12.973  92.003  -47.582 1.00 64.23  ? 410 LEU B CD1 1 
ATOM   7119  C CD2 . LEU B 1 410 ? 12.887  93.132  -45.322 1.00 59.64  ? 410 LEU B CD2 1 
ATOM   7120  N N   . GLU B 1 411 ? 18.118  92.894  -45.804 1.00 61.03  ? 411 GLU B N   1 
ATOM   7121  C CA  . GLU B 1 411 ? 19.348  92.396  -45.220 1.00 61.44  ? 411 GLU B CA  1 
ATOM   7122  C C   . GLU B 1 411 ? 19.821  93.403  -44.183 1.00 59.88  ? 411 GLU B C   1 
ATOM   7123  O O   . GLU B 1 411 ? 20.379  93.012  -43.163 1.00 65.72  ? 411 GLU B O   1 
ATOM   7124  C CB  . GLU B 1 411 ? 20.437  92.149  -46.270 1.00 67.45  ? 411 GLU B CB  1 
ATOM   7125  C CG  . GLU B 1 411 ? 20.110  91.021  -47.247 1.00 70.45  ? 411 GLU B CG  1 
ATOM   7126  C CD  . GLU B 1 411 ? 21.171  90.730  -48.300 1.00 77.31  ? 411 GLU B CD  1 
ATOM   7127  O OE1 . GLU B 1 411 ? 21.600  91.670  -49.006 1.00 82.77  ? 411 GLU B OE1 1 
ATOM   7128  O OE2 . GLU B 1 411 ? 21.557  89.552  -48.428 1.00 76.81  ? 411 GLU B OE2 1 
ATOM   7129  N N   . GLU B 1 412 ? 19.584  94.691  -44.466 1.00 59.37  ? 412 GLU B N   1 
ATOM   7130  C CA  . GLU B 1 412 ? 19.962  95.785  -43.579 1.00 64.37  ? 412 GLU B CA  1 
ATOM   7131  C C   . GLU B 1 412 ? 18.977  95.867  -42.413 1.00 55.33  ? 412 GLU B C   1 
ATOM   7132  O O   . GLU B 1 412 ? 19.379  95.877  -41.256 1.00 55.61  ? 412 GLU B O   1 
ATOM   7133  C CB  . GLU B 1 412 ? 20.006  97.096  -44.378 1.00 65.24  ? 412 GLU B CB  1 
ATOM   7134  C CG  . GLU B 1 412 ? 20.826  98.214  -43.740 1.00 69.67  ? 412 GLU B CG  1 
ATOM   7135  C CD  . GLU B 1 412 ? 20.591  99.618  -44.297 1.00 74.51  ? 412 GLU B CD  1 
ATOM   7136  O OE1 . GLU B 1 412 ? 19.968  99.814  -45.371 1.00 63.03  ? 412 GLU B OE1 1 
ATOM   7137  O OE2 . GLU B 1 412 ? 21.025  100.551 -43.587 1.00 73.15  ? 412 GLU B OE2 1 
ATOM   7138  N N   . ALA B 1 413 ? 17.681  95.929  -42.730 1.00 57.38  ? 413 ALA B N   1 
ATOM   7139  C CA  . ALA B 1 413 ? 16.641  96.150  -41.735 1.00 59.71  ? 413 ALA B CA  1 
ATOM   7140  C C   . ALA B 1 413 ? 16.576  95.032  -40.686 1.00 61.90  ? 413 ALA B C   1 
ATOM   7141  O O   . ALA B 1 413 ? 16.276  95.310  -39.533 1.00 55.90  ? 413 ALA B O   1 
ATOM   7142  C CB  . ALA B 1 413 ? 15.312  96.296  -42.437 1.00 60.01  ? 413 ALA B CB  1 
ATOM   7143  N N   . LEU B 1 414 ? 16.835  93.773  -41.086 1.00 66.33  ? 414 LEU B N   1 
ATOM   7144  C CA  . LEU B 1 414 ? 16.493  92.611  -40.275 1.00 61.44  ? 414 LEU B CA  1 
ATOM   7145  C C   . LEU B 1 414 ? 17.734  91.873  -39.760 1.00 57.87  ? 414 LEU B C   1 
ATOM   7146  O O   . LEU B 1 414 ? 17.597  90.800  -39.183 1.00 61.40  ? 414 LEU B O   1 
ATOM   7147  C CB  . LEU B 1 414 ? 15.565  91.701  -41.090 1.00 57.26  ? 414 LEU B CB  1 
ATOM   7148  C CG  . LEU B 1 414 ? 14.166  92.260  -41.374 1.00 60.90  ? 414 LEU B CG  1 
ATOM   7149  C CD1 . LEU B 1 414 ? 13.266  91.269  -42.095 1.00 59.12  ? 414 LEU B CD1 1 
ATOM   7150  C CD2 . LEU B 1 414 ? 13.503  92.740  -40.088 1.00 65.70  ? 414 LEU B CD2 1 
ATOM   7151  N N   . ARG B 1 415 ? 18.934  92.450  -39.911 1.00 57.45  ? 415 ARG B N   1 
ATOM   7152  C CA  . ARG B 1 415 ? 20.144  91.863  -39.344 1.00 62.19  ? 415 ARG B CA  1 
ATOM   7153  C C   . ARG B 1 415 ? 20.217  92.128  -37.838 1.00 71.14  ? 415 ARG B C   1 
ATOM   7154  O O   . ARG B 1 415 ? 19.559  93.032  -37.317 1.00 70.75  ? 415 ARG B O   1 
ATOM   7155  C CB  . ARG B 1 415 ? 21.444  92.386  -39.975 1.00 62.38  ? 415 ARG B CB  1 
ATOM   7156  C CG  . ARG B 1 415 ? 21.825  93.813  -39.602 1.00 67.73  ? 415 ARG B CG  1 
ATOM   7157  C CD  . ARG B 1 415 ? 23.073  94.295  -40.323 1.00 79.59  ? 415 ARG B CD  1 
ATOM   7158  N NE  . ARG B 1 415 ? 23.081  95.750  -40.532 1.00 84.56  ? 415 ARG B NE  1 
ATOM   7159  C CZ  . ARG B 1 415 ? 23.332  96.693  -39.633 1.00 85.57  ? 415 ARG B CZ  1 
ATOM   7160  N NH1 . ARG B 1 415 ? 23.669  96.382  -38.393 1.00 95.97  ? 415 ARG B NH1 1 
ATOM   7161  N NH2 . ARG B 1 415 ? 23.250  97.960  -39.988 1.00 81.72  ? 415 ARG B NH2 1 
ATOM   7162  N N   . GLY B 1 416 ? 21.063  91.334  -37.163 1.00 76.86  ? 416 GLY B N   1 
ATOM   7163  C CA  . GLY B 1 416 ? 21.427  91.540  -35.769 1.00 77.02  ? 416 GLY B CA  1 
ATOM   7164  C C   . GLY B 1 416 ? 22.917  91.851  -35.644 1.00 79.61  ? 416 GLY B C   1 
ATOM   7165  O O   . GLY B 1 416 ? 23.641  91.823  -36.637 1.00 71.43  ? 416 GLY B O   1 
ATOM   7166  N N   . THR B 1 417 ? 23.371  92.131  -34.415 1.00 80.29  ? 417 THR B N   1 
ATOM   7167  C CA  . THR B 1 417 ? 24.748  92.545  -34.180 1.00 77.33  ? 417 THR B CA  1 
ATOM   7168  C C   . THR B 1 417 ? 25.709  91.520  -34.779 1.00 72.98  ? 417 THR B C   1 
ATOM   7169  O O   . THR B 1 417 ? 26.756  91.897  -35.297 1.00 75.84  ? 417 THR B O   1 
ATOM   7170  C CB  . THR B 1 417 ? 25.014  92.706  -32.681 1.00 77.34  ? 417 THR B CB  1 
ATOM   7171  O OG1 . THR B 1 417 ? 23.831  93.248  -32.104 1.00 68.43  ? 417 THR B OG1 1 
ATOM   7172  C CG2 . THR B 1 417 ? 26.230  93.576  -32.404 1.00 74.73  ? 417 THR B CG2 1 
ATOM   7173  N N   . SER B 1 418 ? 25.362  90.228  -34.663 1.00 72.56  ? 418 SER B N   1 
ATOM   7174  C CA  . SER B 1 418 ? 26.300  89.141  -34.908 1.00 74.17  ? 418 SER B CA  1 
ATOM   7175  C C   . SER B 1 418 ? 25.671  88.034  -35.754 1.00 70.64  ? 418 SER B C   1 
ATOM   7176  O O   . SER B 1 418 ? 26.148  86.903  -35.703 1.00 64.53  ? 418 SER B O   1 
ATOM   7177  C CB  . SER B 1 418 ? 26.820  88.569  -33.596 1.00 74.65  ? 418 SER B CB  1 
ATOM   7178  O OG  . SER B 1 418 ? 27.496  89.548  -32.815 1.00 75.70  ? 418 SER B OG  1 
ATOM   7179  N N   . ILE B 1 419 ? 24.628  88.353  -36.540 1.00 64.80  ? 419 ILE B N   1 
ATOM   7180  C CA  . ILE B 1 419 ? 23.998  87.376  -37.420 1.00 62.00  ? 419 ILE B CA  1 
ATOM   7181  C C   . ILE B 1 419 ? 23.305  88.107  -38.572 1.00 55.52  ? 419 ILE B C   1 
ATOM   7182  O O   . ILE B 1 419 ? 22.548  89.047  -38.345 1.00 62.14  ? 419 ILE B O   1 
ATOM   7183  C CB  . ILE B 1 419 ? 23.029  86.455  -36.636 1.00 59.93  ? 419 ILE B CB  1 
ATOM   7184  C CG1 . ILE B 1 419 ? 22.410  85.374  -37.550 1.00 60.24  ? 419 ILE B CG1 1 
ATOM   7185  C CG2 . ILE B 1 419 ? 21.947  87.258  -35.914 1.00 58.06  ? 419 ILE B CG2 1 
ATOM   7186  C CD1 . ILE B 1 419 ? 21.624  84.284  -36.839 1.00 59.45  ? 419 ILE B CD1 1 
ATOM   7187  N N   . SER B 1 420 ? 23.529  87.651  -39.811 1.00 53.14  ? 420 SER B N   1 
ATOM   7188  C CA  . SER B 1 420 ? 22.897  88.258  -40.976 1.00 55.03  ? 420 SER B CA  1 
ATOM   7189  C C   . SER B 1 420 ? 21.371  88.144  -40.894 1.00 61.20  ? 420 SER B C   1 
ATOM   7190  O O   . SER B 1 420 ? 20.826  87.338  -40.131 1.00 58.01  ? 420 SER B O   1 
ATOM   7191  C CB  . SER B 1 420 ? 23.425  87.656  -42.273 1.00 55.01  ? 420 SER B CB  1 
ATOM   7192  O OG  . SER B 1 420 ? 23.095  86.277  -42.396 1.00 56.28  ? 420 SER B OG  1 
ATOM   7193  N N   . ALA B 1 421 ? 20.684  88.953  -41.712 1.00 57.10  ? 421 ALA B N   1 
ATOM   7194  C CA  . ALA B 1 421 ? 19.235  88.898  -41.807 1.00 57.70  ? 421 ALA B CA  1 
ATOM   7195  C C   . ALA B 1 421 ? 18.783  87.507  -42.262 1.00 59.08  ? 421 ALA B C   1 
ATOM   7196  O O   . ALA B 1 421 ? 17.803  86.974  -41.736 1.00 57.84  ? 421 ALA B O   1 
ATOM   7197  C CB  . ALA B 1 421 ? 18.738  89.962  -42.758 1.00 52.56  ? 421 ALA B CB  1 
ATOM   7198  N N   . ARG B 1 422 ? 19.502  86.944  -43.245 1.00 53.46  ? 422 ARG B N   1 
ATOM   7199  C CA  . ARG B 1 422 ? 19.153  85.674  -43.860 1.00 53.88  ? 422 ARG B CA  1 
ATOM   7200  C C   . ARG B 1 422 ? 19.311  84.526  -42.856 1.00 56.25  ? 422 ARG B C   1 
ATOM   7201  O O   . ARG B 1 422 ? 18.433  83.676  -42.726 1.00 50.40  ? 422 ARG B O   1 
ATOM   7202  C CB  . ARG B 1 422 ? 20.009  85.441  -45.111 1.00 53.19  ? 422 ARG B CB  1 
ATOM   7203  C CG  . ARG B 1 422 ? 19.689  86.359  -46.283 1.00 56.41  ? 422 ARG B CG  1 
ATOM   7204  C CD  . ARG B 1 422 ? 20.600  86.034  -47.466 1.00 57.94  ? 422 ARG B CD  1 
ATOM   7205  N NE  . ARG B 1 422 ? 20.407  86.935  -48.610 1.00 64.49  ? 422 ARG B NE  1 
ATOM   7206  C CZ  . ARG B 1 422 ? 19.818  86.655  -49.785 1.00 67.11  ? 422 ARG B CZ  1 
ATOM   7207  N NH1 . ARG B 1 422 ? 19.260  85.482  -50.041 1.00 67.95  ? 422 ARG B NH1 1 
ATOM   7208  N NH2 . ARG B 1 422 ? 19.771  87.575  -50.725 1.00 65.15  ? 422 ARG B NH2 1 
ATOM   7209  N N   . ASP B 1 423 ? 20.433  84.507  -42.133 1.00 55.51  ? 423 ASP B N   1 
ATOM   7210  C CA  . ASP B 1 423 ? 20.702  83.445  -41.181 1.00 56.15  ? 423 ASP B CA  1 
ATOM   7211  C C   . ASP B 1 423 ? 19.625  83.447  -40.102 1.00 64.59  ? 423 ASP B C   1 
ATOM   7212  O O   . ASP B 1 423 ? 19.101  82.391  -39.741 1.00 59.30  ? 423 ASP B O   1 
ATOM   7213  C CB  . ASP B 1 423 ? 22.096  83.598  -40.597 1.00 63.07  ? 423 ASP B CB  1 
ATOM   7214  C CG  . ASP B 1 423 ? 23.245  83.205  -41.517 1.00 61.26  ? 423 ASP B CG  1 
ATOM   7215  O OD1 . ASP B 1 423 ? 22.984  82.506  -42.509 1.00 58.87  ? 423 ASP B OD1 1 
ATOM   7216  O OD2 . ASP B 1 423 ? 24.391  83.597  -41.226 1.00 73.33  ? 423 ASP B OD2 1 
ATOM   7217  N N   . ARG B 1 424 ? 19.305  84.653  -39.608 1.00 58.02  ? 424 ARG B N   1 
ATOM   7218  C CA  . ARG B 1 424 ? 18.406  84.798  -38.483 1.00 53.42  ? 424 ARG B CA  1 
ATOM   7219  C C   . ARG B 1 424 ? 16.992  84.416  -38.915 1.00 50.52  ? 424 ARG B C   1 
ATOM   7220  O O   . ARG B 1 424 ? 16.255  83.769  -38.168 1.00 49.09  ? 424 ARG B O   1 
ATOM   7221  C CB  . ARG B 1 424 ? 18.469  86.210  -37.884 1.00 52.94  ? 424 ARG B CB  1 
ATOM   7222  C CG  . ARG B 1 424 ? 17.614  86.325  -36.628 1.00 57.76  ? 424 ARG B CG  1 
ATOM   7223  C CD  . ARG B 1 424 ? 17.984  87.468  -35.700 1.00 62.57  ? 424 ARG B CD  1 
ATOM   7224  N NE  . ARG B 1 424 ? 17.600  88.787  -36.213 1.00 64.23  ? 424 ARG B NE  1 
ATOM   7225  C CZ  . ARG B 1 424 ? 17.695  89.906  -35.506 1.00 62.94  ? 424 ARG B CZ  1 
ATOM   7226  N NH1 . ARG B 1 424 ? 18.052  89.859  -34.238 1.00 64.04  ? 424 ARG B NH1 1 
ATOM   7227  N NH2 . ARG B 1 424 ? 17.430  91.070  -36.063 1.00 60.62  ? 424 ARG B NH2 1 
ATOM   7228  N N   . VAL B 1 425 ? 16.605  84.814  -40.122 1.00 47.10  ? 425 VAL B N   1 
ATOM   7229  C CA  . VAL B 1 425 ? 15.256  84.526  -40.577 1.00 50.90  ? 425 VAL B CA  1 
ATOM   7230  C C   . VAL B 1 425 ? 15.088  83.021  -40.845 1.00 56.13  ? 425 VAL B C   1 
ATOM   7231  O O   . VAL B 1 425 ? 13.992  82.483  -40.674 1.00 50.49  ? 425 VAL B O   1 
ATOM   7232  C CB  . VAL B 1 425 ? 14.941  85.425  -41.782 1.00 47.04  ? 425 VAL B CB  1 
ATOM   7233  C CG1 . VAL B 1 425 ? 13.730  84.947  -42.570 1.00 50.17  ? 425 VAL B CG1 1 
ATOM   7234  C CG2 . VAL B 1 425 ? 14.758  86.868  -41.317 1.00 48.98  ? 425 VAL B CG2 1 
ATOM   7235  N N   . SER B 1 426 ? 16.174  82.316  -41.191 1.00 51.41  ? 426 SER B N   1 
ATOM   7236  C CA  . SER B 1 426 ? 16.107  80.870  -41.366 1.00 59.90  ? 426 SER B CA  1 
ATOM   7237  C C   . SER B 1 426 ? 15.927  80.138  -40.031 1.00 56.10  ? 426 SER B C   1 
ATOM   7238  O O   . SER B 1 426 ? 15.477  78.997  -40.040 1.00 55.24  ? 426 SER B O   1 
ATOM   7239  C CB  . SER B 1 426 ? 17.309  80.332  -42.132 1.00 58.64  ? 426 SER B CB  1 
ATOM   7240  O OG  . SER B 1 426 ? 18.436  80.257  -41.278 1.00 60.61  ? 426 SER B OG  1 
ATOM   7241  N N   . ILE B 1 427 ? 16.252  80.777  -38.890 1.00 53.89  ? 427 ILE B N   1 
ATOM   7242  C CA  . ILE B 1 427 ? 15.882  80.226  -37.589 1.00 54.64  ? 427 ILE B CA  1 
ATOM   7243  C C   . ILE B 1 427 ? 14.361  80.298  -37.436 1.00 56.31  ? 427 ILE B C   1 
ATOM   7244  O O   . ILE B 1 427 ? 13.730  79.357  -36.947 1.00 53.20  ? 427 ILE B O   1 
ATOM   7245  C CB  . ILE B 1 427 ? 16.567  80.912  -36.389 1.00 56.85  ? 427 ILE B CB  1 
ATOM   7246  C CG1 . ILE B 1 427 ? 18.082  81.117  -36.582 1.00 57.99  ? 427 ILE B CG1 1 
ATOM   7247  C CG2 . ILE B 1 427 ? 16.277  80.132  -35.097 1.00 53.22  ? 427 ILE B CG2 1 
ATOM   7248  C CD1 . ILE B 1 427 ? 18.773  81.763  -35.387 1.00 55.39  ? 427 ILE B CD1 1 
ATOM   7249  N N   . PHE B 1 428 ? 13.787  81.436  -37.832 1.00 53.85  ? 428 PHE B N   1 
ATOM   7250  C CA  . PHE B 1 428 ? 12.353  81.646  -37.724 1.00 61.61  ? 428 PHE B CA  1 
ATOM   7251  C C   . PHE B 1 428 ? 11.643  80.611  -38.597 1.00 58.49  ? 428 PHE B C   1 
ATOM   7252  O O   . PHE B 1 428 ? 10.689  79.983  -38.140 1.00 51.58  ? 428 PHE B O   1 
ATOM   7253  C CB  . PHE B 1 428 ? 11.905  83.083  -38.049 1.00 61.19  ? 428 PHE B CB  1 
ATOM   7254  C CG  . PHE B 1 428 ? 12.331  84.171  -37.064 1.00 65.26  ? 428 PHE B CG  1 
ATOM   7255  C CD1 . PHE B 1 428 ? 11.827  84.204  -35.765 1.00 68.86  ? 428 PHE B CD1 1 
ATOM   7256  C CD2 . PHE B 1 428 ? 13.178  85.207  -37.460 1.00 69.92  ? 428 PHE B CD2 1 
ATOM   7257  C CE1 . PHE B 1 428 ? 12.204  85.209  -34.881 1.00 68.94  ? 428 PHE B CE1 1 
ATOM   7258  C CE2 . PHE B 1 428 ? 13.545  86.213  -36.575 1.00 67.09  ? 428 PHE B CE2 1 
ATOM   7259  C CZ  . PHE B 1 428 ? 13.066  86.205  -35.285 1.00 66.45  ? 428 PHE B CZ  1 
ATOM   7260  N N   . ARG B 1 429 ? 12.134  80.425  -39.830 1.00 55.42  ? 429 ARG B N   1 
ATOM   7261  C CA  . ARG B 1 429 ? 11.495  79.553  -40.803 1.00 54.90  ? 429 ARG B CA  1 
ATOM   7262  C C   . ARG B 1 429 ? 11.591  78.073  -40.390 1.00 55.84  ? 429 ARG B C   1 
ATOM   7263  O O   . ARG B 1 429 ? 10.664  77.300  -40.636 1.00 58.99  ? 429 ARG B O   1 
ATOM   7264  C CB  . ARG B 1 429 ? 12.055  79.869  -42.199 1.00 52.10  ? 429 ARG B CB  1 
ATOM   7265  C CG  . ARG B 1 429 ? 11.372  81.048  -42.881 1.00 55.64  ? 429 ARG B CG  1 
ATOM   7266  C CD  . ARG B 1 429 ? 11.759  81.248  -44.351 1.00 58.22  ? 429 ARG B CD  1 
ATOM   7267  N NE  . ARG B 1 429 ? 10.960  82.281  -45.020 1.00 62.18  ? 429 ARG B NE  1 
ATOM   7268  C CZ  . ARG B 1 429 ? 9.696   82.148  -45.397 1.00 67.79  ? 429 ARG B CZ  1 
ATOM   7269  N NH1 . ARG B 1 429 ? 9.143   80.946  -45.438 1.00 67.20  ? 429 ARG B NH1 1 
ATOM   7270  N NH2 . ARG B 1 429 ? 8.992   83.217  -45.748 1.00 71.49  ? 429 ARG B NH2 1 
ATOM   7271  N N   . GLN B 1 430 ? 12.701  77.671  -39.763 1.00 48.10  ? 430 GLN B N   1 
ATOM   7272  C CA  . GLN B 1 430 ? 12.839  76.341  -39.189 1.00 48.23  ? 430 GLN B CA  1 
ATOM   7273  C C   . GLN B 1 430 ? 11.759  76.101  -38.124 1.00 55.70  ? 430 GLN B C   1 
ATOM   7274  O O   . GLN B 1 430 ? 11.113  75.042  -38.085 1.00 47.41  ? 430 GLN B O   1 
ATOM   7275  C CB  . GLN B 1 430 ? 14.259  76.285  -38.625 1.00 49.93  ? 430 GLN B CB  1 
ATOM   7276  C CG  . GLN B 1 430 ? 14.702  74.938  -38.069 1.00 52.58  ? 430 GLN B CG  1 
ATOM   7277  C CD  . GLN B 1 430 ? 14.790  73.823  -39.102 1.00 57.36  ? 430 GLN B CD  1 
ATOM   7278  O OE1 . GLN B 1 430 ? 14.493  72.659  -38.800 1.00 53.39  ? 430 GLN B OE1 1 
ATOM   7279  N NE2 . GLN B 1 430 ? 15.239  74.142  -40.311 1.00 52.92  ? 430 GLN B NE2 1 
ATOM   7280  N N   . ILE B 1 431 ? 11.538  77.112  -37.271 1.00 49.14  ? 431 ILE B N   1 
ATOM   7281  C CA  . ILE B 1 431 ? 10.551  77.019  -36.210 1.00 50.14  ? 431 ILE B CA  1 
ATOM   7282  C C   . ILE B 1 431 ? 9.141   77.021  -36.814 1.00 52.20  ? 431 ILE B C   1 
ATOM   7283  O O   . ILE B 1 431 ? 8.304   76.234  -36.399 1.00 53.44  ? 431 ILE B O   1 
ATOM   7284  C CB  . ILE B 1 431 ? 10.791  78.134  -35.171 1.00 52.57  ? 431 ILE B CB  1 
ATOM   7285  C CG1 . ILE B 1 431 ? 12.176  77.978  -34.496 1.00 54.53  ? 431 ILE B CG1 1 
ATOM   7286  C CG2 . ILE B 1 431 ? 9.655   78.198  -34.151 1.00 53.71  ? 431 ILE B CG2 1 
ATOM   7287  C CD1 . ILE B 1 431 ? 12.503  79.037  -33.457 1.00 52.20  ? 431 ILE B CD1 1 
ATOM   7288  N N   . SER B 1 432 ? 8.884   77.876  -37.812 1.00 58.92  ? 432 SER B N   1 
ATOM   7289  C CA  . SER B 1 432 ? 7.591   77.958  -38.492 1.00 62.29  ? 432 SER B CA  1 
ATOM   7290  C C   . SER B 1 432 ? 7.249   76.643  -39.191 1.00 52.63  ? 432 SER B C   1 
ATOM   7291  O O   . SER B 1 432 ? 6.103   76.180  -39.162 1.00 52.46  ? 432 SER B O   1 
ATOM   7292  C CB  . SER B 1 432 ? 7.546   79.108  -39.508 1.00 53.62  ? 432 SER B CB  1 
ATOM   7293  O OG  . SER B 1 432 ? 7.378   80.337  -38.825 1.00 68.88  ? 432 SER B OG  1 
ATOM   7294  N N   . GLU B 1 433 ? 8.239   76.110  -39.898 1.00 44.19  ? 433 GLU B N   1 
ATOM   7295  C CA  . GLU B 1 433 ? 8.050   74.880  -40.646 1.00 54.68  ? 433 GLU B CA  1 
ATOM   7296  C C   . GLU B 1 433 ? 7.552   73.765  -39.716 1.00 53.38  ? 433 GLU B C   1 
ATOM   7297  O O   . GLU B 1 433 ? 6.581   73.086  -40.052 1.00 48.13  ? 433 GLU B O   1 
ATOM   7298  C CB  . GLU B 1 433 ? 9.354   74.505  -41.349 1.00 52.55  ? 433 GLU B CB  1 
ATOM   7299  C CG  . GLU B 1 433 ? 9.186   73.437  -42.417 1.00 50.05  ? 433 GLU B CG  1 
ATOM   7300  C CD  . GLU B 1 433 ? 8.755   73.919  -43.786 1.00 52.87  ? 433 GLU B CD  1 
ATOM   7301  O OE1 . GLU B 1 433 ? 7.769   74.686  -43.904 1.00 61.55  ? 433 GLU B OE1 1 
ATOM   7302  O OE2 . GLU B 1 433 ? 9.403   73.440  -44.751 1.00 55.48  ? 433 GLU B OE2 1 
ATOM   7303  N N   . ARG B 1 434 ? 8.203   73.603  -38.550 1.00 50.27  ? 434 ARG B N   1 
ATOM   7304  C CA  . ARG B 1 434 ? 7.936   72.488  -37.645 1.00 50.40  ? 434 ARG B CA  1 
ATOM   7305  C C   . ARG B 1 434 ? 6.646   72.694  -36.853 1.00 51.09  ? 434 ARG B C   1 
ATOM   7306  O O   . ARG B 1 434 ? 5.943   71.723  -36.587 1.00 54.70  ? 434 ARG B O   1 
ATOM   7307  C CB  . ARG B 1 434 ? 9.044   72.282  -36.605 1.00 42.94  ? 434 ARG B CB  1 
ATOM   7308  C CG  . ARG B 1 434 ? 10.391  71.897  -37.204 1.00 45.40  ? 434 ARG B CG  1 
ATOM   7309  C CD  . ARG B 1 434 ? 11.556  72.174  -36.241 1.00 46.28  ? 434 ARG B CD  1 
ATOM   7310  N NE  . ARG B 1 434 ? 12.804  71.697  -36.831 1.00 47.20  ? 434 ARG B NE  1 
ATOM   7311  C CZ  . ARG B 1 434 ? 13.064  70.396  -37.018 1.00 54.90  ? 434 ARG B CZ  1 
ATOM   7312  N NH1 . ARG B 1 434 ? 12.290  69.479  -36.446 1.00 45.34  ? 434 ARG B NH1 1 
ATOM   7313  N NH2 . ARG B 1 434 ? 14.139  70.027  -37.704 1.00 50.28  ? 434 ARG B NH2 1 
ATOM   7314  N N   . TYR B 1 435 ? 6.351   73.932  -36.420 1.00 47.77  ? 435 TYR B N   1 
ATOM   7315  C CA  . TYR B 1 435 ? 5.264   74.109  -35.464 1.00 48.09  ? 435 TYR B CA  1 
ATOM   7316  C C   . TYR B 1 435 ? 4.140   75.021  -35.969 1.00 48.43  ? 435 TYR B C   1 
ATOM   7317  O O   . TYR B 1 435 ? 3.180   75.221  -35.229 1.00 49.78  ? 435 TYR B O   1 
ATOM   7318  C CB  . TYR B 1 435 ? 5.881   74.541  -34.136 1.00 43.97  ? 435 TYR B CB  1 
ATOM   7319  C CG  . TYR B 1 435 ? 7.077   73.699  -33.716 1.00 46.45  ? 435 TYR B CG  1 
ATOM   7320  C CD1 . TYR B 1 435 ? 6.932   72.367  -33.337 1.00 48.09  ? 435 TYR B CD1 1 
ATOM   7321  C CD2 . TYR B 1 435 ? 8.352   74.246  -33.680 1.00 41.68  ? 435 TYR B CD2 1 
ATOM   7322  C CE1 . TYR B 1 435 ? 8.036   71.606  -32.990 1.00 43.52  ? 435 TYR B CE1 1 
ATOM   7323  C CE2 . TYR B 1 435 ? 9.453   73.500  -33.311 1.00 45.25  ? 435 TYR B CE2 1 
ATOM   7324  C CZ  . TYR B 1 435 ? 9.299   72.170  -32.971 1.00 45.26  ? 435 TYR B CZ  1 
ATOM   7325  O OH  . TYR B 1 435 ? 10.417  71.448  -32.619 1.00 50.28  ? 435 TYR B OH  1 
ATOM   7326  N N   . LEU B 1 436 ? 4.225   75.539  -37.211 1.00 49.68  ? 436 LEU B N   1 
ATOM   7327  C CA  . LEU B 1 436 ? 3.233   76.483  -37.708 1.00 48.65  ? 436 LEU B CA  1 
ATOM   7328  C C   . LEU B 1 436 ? 2.822   76.197  -39.156 1.00 52.61  ? 436 LEU B C   1 
ATOM   7329  O O   . LEU B 1 436 ? 2.271   77.089  -39.805 1.00 52.58  ? 436 LEU B O   1 
ATOM   7330  C CB  . LEU B 1 436 ? 3.729   77.923  -37.550 1.00 51.68  ? 436 LEU B CB  1 
ATOM   7331  C CG  . LEU B 1 436 ? 3.967   78.419  -36.117 1.00 51.84  ? 436 LEU B CG  1 
ATOM   7332  C CD1 . LEU B 1 436 ? 4.574   79.795  -36.197 1.00 51.68  ? 436 LEU B CD1 1 
ATOM   7333  C CD2 . LEU B 1 436 ? 2.728   78.448  -35.222 1.00 48.90  ? 436 LEU B CD2 1 
ATOM   7334  N N   . THR B 1 437 ? 2.999   74.949  -39.632 1.00 53.17  ? 437 THR B N   1 
ATOM   7335  C CA  . THR B 1 437 ? 2.519   74.534  -40.948 1.00 48.36  ? 437 THR B CA  1 
ATOM   7336  C C   . THR B 1 437 ? 1.736   73.244  -40.764 1.00 53.18  ? 437 THR B C   1 
ATOM   7337  O O   . THR B 1 437 ? 1.900   72.580  -39.747 1.00 54.25  ? 437 THR B O   1 
ATOM   7338  C CB  . THR B 1 437 ? 3.666   74.306  -41.934 1.00 46.56  ? 437 THR B CB  1 
ATOM   7339  O OG1 . THR B 1 437 ? 4.523   73.351  -41.303 1.00 50.63  ? 437 THR B OG1 1 
ATOM   7340  C CG2 . THR B 1 437 ? 4.456   75.560  -42.277 1.00 41.70  ? 437 THR B CG2 1 
ATOM   7341  N N   . GLN B 1 438 ? 0.896   72.909  -41.753 1.00 58.74  ? 438 GLN B N   1 
ATOM   7342  C CA  . GLN B 1 438 ? 0.181   71.643  -41.761 1.00 61.94  ? 438 GLN B CA  1 
ATOM   7343  C C   . GLN B 1 438 ? 1.208   70.511  -41.847 1.00 51.63  ? 438 GLN B C   1 
ATOM   7344  O O   . GLN B 1 438 ? 1.068   69.489  -41.168 1.00 42.60  ? 438 GLN B O   1 
ATOM   7345  C CB  . GLN B 1 438 ? -0.952  71.616  -42.794 1.00 63.10  ? 438 GLN B CB  1 
ATOM   7346  C CG  . GLN B 1 438 ? -0.518  71.647  -44.257 1.00 85.44  ? 438 GLN B CG  1 
ATOM   7347  C CD  . GLN B 1 438 ? -0.326  73.033  -44.846 1.00 102.38 ? 438 GLN B CD  1 
ATOM   7348  O OE1 . GLN B 1 438 ? -1.289  73.718  -45.219 1.00 87.32  ? 438 GLN B OE1 1 
ATOM   7349  N NE2 . GLN B 1 438 ? 0.933   73.422  -45.013 1.00 111.63 ? 438 GLN B NE2 1 
ATOM   7350  N N   . TRP B 1 439 ? 2.260   70.733  -42.643 1.00 47.77  ? 439 TRP B N   1 
ATOM   7351  C CA  . TRP B 1 439 ? 3.379   69.813  -42.728 1.00 49.03  ? 439 TRP B CA  1 
ATOM   7352  C C   . TRP B 1 439 ? 3.894   69.473  -41.327 1.00 54.76  ? 439 TRP B C   1 
ATOM   7353  O O   . TRP B 1 439 ? 3.983   68.296  -40.978 1.00 52.04  ? 439 TRP B O   1 
ATOM   7354  C CB  . TRP B 1 439 ? 4.499   70.390  -43.594 1.00 48.24  ? 439 TRP B CB  1 
ATOM   7355  C CG  . TRP B 1 439 ? 5.657   69.455  -43.711 1.00 49.28  ? 439 TRP B CG  1 
ATOM   7356  C CD1 . TRP B 1 439 ? 5.854   68.506  -44.669 1.00 53.37  ? 439 TRP B CD1 1 
ATOM   7357  C CD2 . TRP B 1 439 ? 6.741   69.323  -42.774 1.00 56.67  ? 439 TRP B CD2 1 
ATOM   7358  N NE1 . TRP B 1 439 ? 7.005   67.804  -44.412 1.00 53.94  ? 439 TRP B NE1 1 
ATOM   7359  C CE2 . TRP B 1 439 ? 7.569   68.279  -43.254 1.00 58.01  ? 439 TRP B CE2 1 
ATOM   7360  C CE3 . TRP B 1 439 ? 7.087   69.974  -41.587 1.00 54.78  ? 439 TRP B CE3 1 
ATOM   7361  C CZ2 . TRP B 1 439 ? 8.731   67.890  -42.592 1.00 56.04  ? 439 TRP B CZ2 1 
ATOM   7362  C CZ3 . TRP B 1 439 ? 8.236   69.585  -40.937 1.00 55.81  ? 439 TRP B CZ3 1 
ATOM   7363  C CH2 . TRP B 1 439 ? 9.037   68.552  -41.428 1.00 57.19  ? 439 TRP B CH2 1 
ATOM   7364  N N   . GLY B 1 440 ? 4.188   70.498  -40.518 1.00 44.26  ? 440 GLY B N   1 
ATOM   7365  C CA  . GLY B 1 440 ? 4.782   70.271  -39.217 1.00 47.31  ? 440 GLY B CA  1 
ATOM   7366  C C   . GLY B 1 440 ? 3.739   69.805  -38.205 1.00 48.24  ? 440 GLY B C   1 
ATOM   7367  O O   . GLY B 1 440 ? 4.063   69.076  -37.272 1.00 55.31  ? 440 GLY B O   1 
ATOM   7368  N N   . ALA B 1 441 ? 2.491   70.232  -38.412 1.00 49.40  ? 441 ALA B N   1 
ATOM   7369  C CA  . ALA B 1 441 ? 1.388   69.937  -37.512 1.00 49.72  ? 441 ALA B CA  1 
ATOM   7370  C C   . ALA B 1 441 ? 1.158   68.428  -37.427 1.00 50.19  ? 441 ALA B C   1 
ATOM   7371  O O   . ALA B 1 441 ? 0.956   67.900  -36.343 1.00 53.02  ? 441 ALA B O   1 
ATOM   7372  C CB  . ALA B 1 441 ? 0.137   70.665  -37.982 1.00 48.42  ? 441 ALA B CB  1 
ATOM   7373  N N   . ARG B 1 442 ? 1.165   67.754  -38.584 1.00 53.32  ? 442 ARG B N   1 
ATOM   7374  C CA  . ARG B 1 442 ? 1.140   66.303  -38.644 1.00 58.58  ? 442 ARG B CA  1 
ATOM   7375  C C   . ARG B 1 442 ? 2.115   65.700  -37.623 1.00 59.51  ? 442 ARG B C   1 
ATOM   7376  O O   . ARG B 1 442 ? 1.753   64.766  -36.926 1.00 55.29  ? 442 ARG B O   1 
ATOM   7377  C CB  . ARG B 1 442 ? 1.436   65.801  -40.066 1.00 61.04  ? 442 ARG B CB  1 
ATOM   7378  C CG  . ARG B 1 442 ? 1.538   64.281  -40.174 1.00 65.94  ? 442 ARG B CG  1 
ATOM   7379  C CD  . ARG B 1 442 ? 2.949   63.690  -40.004 1.00 66.68  ? 442 ARG B CD  1 
ATOM   7380  N NE  . ARG B 1 442 ? 2.999   62.218  -39.951 1.00 65.45  ? 442 ARG B NE  1 
ATOM   7381  C CZ  . ARG B 1 442 ? 4.102   61.473  -39.715 1.00 65.62  ? 442 ARG B CZ  1 
ATOM   7382  N NH1 . ARG B 1 442 ? 5.299   62.033  -39.553 1.00 59.46  ? 442 ARG B NH1 1 
ATOM   7383  N NH2 . ARG B 1 442 ? 4.013   60.152  -39.646 1.00 63.75  ? 442 ARG B NH2 1 
ATOM   7384  N N   . HIS B 1 443 ? 3.357   66.196  -37.538 1.00 58.80  ? 443 HIS B N   1 
ATOM   7385  C CA  . HIS B 1 443 ? 4.341   65.605  -36.641 1.00 57.87  ? 443 HIS B CA  1 
ATOM   7386  C C   . HIS B 1 443 ? 3.834   65.624  -35.188 1.00 63.93  ? 443 HIS B C   1 
ATOM   7387  O O   . HIS B 1 443 ? 3.762   64.585  -34.516 1.00 56.74  ? 443 HIS B O   1 
ATOM   7388  C CB  . HIS B 1 443 ? 5.704   66.290  -36.804 1.00 57.24  ? 443 HIS B CB  1 
ATOM   7389  C CG  . HIS B 1 443 ? 6.685   65.802  -35.791 1.00 62.05  ? 443 HIS B CG  1 
ATOM   7390  N ND1 . HIS B 1 443 ? 6.745   66.308  -34.510 1.00 59.40  ? 443 HIS B ND1 1 
ATOM   7391  C CD2 . HIS B 1 443 ? 7.586   64.806  -35.841 1.00 61.30  ? 443 HIS B CD2 1 
ATOM   7392  C CE1 . HIS B 1 443 ? 7.688   65.660  -33.832 1.00 64.93  ? 443 HIS B CE1 1 
ATOM   7393  N NE2 . HIS B 1 443 ? 8.200   64.731  -34.618 1.00 61.16  ? 443 HIS B NE2 1 
ATOM   7394  N N   . GLU B 1 444 ? 3.465   66.814  -34.699 1.00 56.23  ? 444 GLU B N   1 
ATOM   7395  C CA  . GLU B 1 444 ? 3.018   66.978  -33.321 1.00 55.84  ? 444 GLU B CA  1 
ATOM   7396  C C   . GLU B 1 444 ? 1.771   66.130  -33.085 1.00 55.80  ? 444 GLU B C   1 
ATOM   7397  O O   . GLU B 1 444 ? 1.606   65.560  -32.015 1.00 55.33  ? 444 GLU B O   1 
ATOM   7398  C CB  . GLU B 1 444 ? 2.703   68.447  -33.007 1.00 54.82  ? 444 GLU B CB  1 
ATOM   7399  C CG  . GLU B 1 444 ? 3.860   69.393  -33.324 1.00 58.77  ? 444 GLU B CG  1 
ATOM   7400  C CD  . GLU B 1 444 ? 5.184   69.026  -32.675 1.00 54.61  ? 444 GLU B CD  1 
ATOM   7401  O OE1 . GLU B 1 444 ? 5.232   69.083  -31.439 1.00 52.13  ? 444 GLU B OE1 1 
ATOM   7402  O OE2 . GLU B 1 444 ? 6.143   68.680  -33.383 1.00 56.70  ? 444 GLU B OE2 1 
ATOM   7403  N N   . MET B 1 445 ? 0.883   66.077  -34.088 1.00 56.40  ? 445 MET B N   1 
ATOM   7404  C CA  . MET B 1 445 ? -0.367  65.344  -33.965 1.00 64.93  ? 445 MET B CA  1 
ATOM   7405  C C   . MET B 1 445 ? -0.106  63.840  -33.907 1.00 67.43  ? 445 MET B C   1 
ATOM   7406  O O   . MET B 1 445 ? -0.823  63.127  -33.196 1.00 57.07  ? 445 MET B O   1 
ATOM   7407  C CB  . MET B 1 445 ? -1.329  65.665  -35.115 1.00 66.21  ? 445 MET B CB  1 
ATOM   7408  C CG  . MET B 1 445 ? -1.974  67.039  -35.022 1.00 63.72  ? 445 MET B CG  1 
ATOM   7409  S SD  . MET B 1 445 ? -2.553  67.438  -33.360 1.00 59.43  ? 445 MET B SD  1 
ATOM   7410  C CE  . MET B 1 445 ? -1.214  68.427  -32.672 1.00 60.07  ? 445 MET B CE  1 
ATOM   7411  N N   . PHE B 1 446 ? 0.916   63.386  -34.656 1.00 70.23  ? 446 PHE B N   1 
ATOM   7412  C CA  . PHE B 1 446 ? 1.372   62.000  -34.640 1.00 74.21  ? 446 PHE B CA  1 
ATOM   7413  C C   . PHE B 1 446 ? 1.849   61.643  -33.228 1.00 66.64  ? 446 PHE B C   1 
ATOM   7414  O O   . PHE B 1 446 ? 1.372   60.660  -32.672 1.00 60.52  ? 446 PHE B O   1 
ATOM   7415  C CB  . PHE B 1 446 ? 2.441   61.728  -35.712 1.00 70.89  ? 446 PHE B CB  1 
ATOM   7416  C CG  . PHE B 1 446 ? 3.058   60.333  -35.639 1.00 71.92  ? 446 PHE B CG  1 
ATOM   7417  C CD1 . PHE B 1 446 ? 4.153   60.073  -34.805 1.00 77.41  ? 446 PHE B CD1 1 
ATOM   7418  C CD2 . PHE B 1 446 ? 2.540   59.282  -36.387 1.00 65.85  ? 446 PHE B CD2 1 
ATOM   7419  C CE1 . PHE B 1 446 ? 4.712   58.802  -34.720 1.00 61.48  ? 446 PHE B CE1 1 
ATOM   7420  C CE2 . PHE B 1 446 ? 3.113   58.017  -36.302 1.00 70.86  ? 446 PHE B CE2 1 
ATOM   7421  C CZ  . PHE B 1 446 ? 4.199   57.786  -35.477 1.00 62.65  ? 446 PHE B CZ  1 
ATOM   7422  N N   . GLU B 1 447 ? 2.749   62.465  -32.655 1.00 64.67  ? 447 GLU B N   1 
ATOM   7423  C CA  . GLU B 1 447 ? 3.356   62.219  -31.351 1.00 64.25  ? 447 GLU B CA  1 
ATOM   7424  C C   . GLU B 1 447 ? 2.305   62.200  -30.240 1.00 61.32  ? 447 GLU B C   1 
ATOM   7425  O O   . GLU B 1 447 ? 2.490   61.513  -29.235 1.00 56.30  ? 447 GLU B O   1 
ATOM   7426  C CB  . GLU B 1 447 ? 4.443   63.237  -30.988 1.00 63.77  ? 447 GLU B CB  1 
ATOM   7427  C CG  . GLU B 1 447 ? 5.673   63.203  -31.897 1.00 71.86  ? 447 GLU B CG  1 
ATOM   7428  C CD  . GLU B 1 447 ? 6.599   61.993  -31.767 1.00 70.42  ? 447 GLU B CD  1 
ATOM   7429  O OE1 . GLU B 1 447 ? 6.111   60.836  -31.701 1.00 68.32  ? 447 GLU B OE1 1 
ATOM   7430  O OE2 . GLU B 1 447 ? 7.831   62.226  -31.770 1.00 66.02  ? 447 GLU B OE2 1 
ATOM   7431  N N   . LYS B 1 448 ? 1.192   62.916  -30.448 1.00 61.99  ? 448 LYS B N   1 
ATOM   7432  C CA  . LYS B 1 448 ? 0.101   62.978  -29.479 1.00 68.95  ? 448 LYS B CA  1 
ATOM   7433  C C   . LYS B 1 448 ? -0.656  61.644  -29.422 1.00 64.97  ? 448 LYS B C   1 
ATOM   7434  O O   . LYS B 1 448 ? -0.930  61.129  -28.331 1.00 69.98  ? 448 LYS B O   1 
ATOM   7435  C CB  . LYS B 1 448 ? -0.784  64.169  -29.870 1.00 70.11  ? 448 LYS B CB  1 
ATOM   7436  C CG  . LYS B 1 448 ? -1.462  64.925  -28.752 1.00 76.52  ? 448 LYS B CG  1 
ATOM   7437  C CD  . LYS B 1 448 ? -1.553  66.410  -29.091 1.00 78.23  ? 448 LYS B CD  1 
ATOM   7438  C CE  . LYS B 1 448 ? -1.857  67.304  -27.929 1.00 82.24  ? 448 LYS B CE  1 
ATOM   7439  N NZ  . LYS B 1 448 ? -0.894  67.260  -26.817 1.00 76.02  ? 448 LYS B NZ  1 
ATOM   7440  N N   . PHE B 1 449 ? -0.980  61.090  -30.604 1.00 60.74  ? 449 PHE B N   1 
ATOM   7441  C CA  . PHE B 1 449 ? -1.890  59.958  -30.718 1.00 71.10  ? 449 PHE B CA  1 
ATOM   7442  C C   . PHE B 1 449 ? -1.154  58.713  -31.230 1.00 66.03  ? 449 PHE B C   1 
ATOM   7443  O O   . PHE B 1 449 ? -1.774  57.822  -31.782 1.00 66.10  ? 449 PHE B O   1 
ATOM   7444  C CB  . PHE B 1 449 ? -3.071  60.373  -31.618 1.00 79.23  ? 449 PHE B CB  1 
ATOM   7445  C CG  . PHE B 1 449 ? -3.725  61.713  -31.287 1.00 75.01  ? 449 PHE B CG  1 
ATOM   7446  C CD1 . PHE B 1 449 ? -4.415  61.898  -30.092 1.00 79.02  ? 449 PHE B CD1 1 
ATOM   7447  C CD2 . PHE B 1 449 ? -3.665  62.784  -32.178 1.00 79.16  ? 449 PHE B CD2 1 
ATOM   7448  C CE1 . PHE B 1 449 ? -4.991  63.128  -29.791 1.00 82.06  ? 449 PHE B CE1 1 
ATOM   7449  C CE2 . PHE B 1 449 ? -4.237  64.014  -31.871 1.00 75.62  ? 449 PHE B CE2 1 
ATOM   7450  C CZ  . PHE B 1 449 ? -4.907  64.179  -30.685 1.00 83.04  ? 449 PHE B CZ  1 
ATOM   7451  N N   . ASN B 1 450 ? 0.172   58.659  -31.072 1.00 78.63  ? 450 ASN B N   1 
ATOM   7452  C CA  . ASN B 1 450 ? 0.973   57.490  -31.415 1.00 93.47  ? 450 ASN B CA  1 
ATOM   7453  C C   . ASN B 1 450 ? 0.958   56.535  -30.219 1.00 87.81  ? 450 ASN B C   1 
ATOM   7454  O O   . ASN B 1 450 ? 1.245   56.948  -29.100 1.00 99.83  ? 450 ASN B O   1 
ATOM   7455  C CB  . ASN B 1 450 ? 2.376   57.928  -31.850 1.00 101.19 ? 450 ASN B CB  1 
ATOM   7456  C CG  . ASN B 1 450 ? 3.406   56.818  -31.885 1.00 91.46  ? 450 ASN B CG  1 
ATOM   7457  O OD1 . ASN B 1 450 ? 3.182   55.769  -32.507 1.00 77.93  ? 450 ASN B OD1 1 
ATOM   7458  N ND2 . ASN B 1 450 ? 4.549   57.044  -31.249 1.00 82.50  ? 450 ASN B ND2 1 
ATOM   7459  N N   . GLY B 1 451 ? 0.609   55.265  -30.450 1.00 85.37  ? 451 GLY B N   1 
ATOM   7460  C CA  . GLY B 1 451 ? 0.394   54.324  -29.360 1.00 87.36  ? 451 GLY B CA  1 
ATOM   7461  C C   . GLY B 1 451 ? -0.560  54.886  -28.299 1.00 79.27  ? 451 GLY B C   1 
ATOM   7462  O O   . GLY B 1 451 ? -1.565  55.521  -28.630 1.00 65.49  ? 451 GLY B O   1 
ATOM   7463  N N   . THR B 1 452 ? -0.184  54.679  -27.026 1.00 72.60  ? 452 THR B N   1 
ATOM   7464  C CA  . THR B 1 452 ? -0.984  55.031  -25.860 1.00 75.32  ? 452 THR B CA  1 
ATOM   7465  C C   . THR B 1 452 ? -0.941  56.546  -25.609 1.00 71.78  ? 452 THR B C   1 
ATOM   7466  O O   . THR B 1 452 ? 0.096   57.070  -25.214 1.00 61.40  ? 452 THR B O   1 
ATOM   7467  C CB  . THR B 1 452 ? -0.418  54.251  -24.669 1.00 69.72  ? 452 THR B CB  1 
ATOM   7468  O OG1 . THR B 1 452 ? -0.357  52.881  -25.048 1.00 61.28  ? 452 THR B OG1 1 
ATOM   7469  C CG2 . THR B 1 452 ? -1.261  54.368  -23.413 1.00 74.28  ? 452 THR B CG2 1 
ATOM   7470  N N   . PRO B 1 453 ? -2.040  57.324  -25.795 1.00 75.24  ? 453 PRO B N   1 
ATOM   7471  C CA  . PRO B 1 453 ? -2.046  58.733  -25.375 1.00 74.91  ? 453 PRO B CA  1 
ATOM   7472  C C   . PRO B 1 453 ? -2.077  58.933  -23.851 1.00 66.91  ? 453 PRO B C   1 
ATOM   7473  O O   . PRO B 1 453 ? -2.352  58.006  -23.087 1.00 56.34  ? 453 PRO B O   1 
ATOM   7474  C CB  . PRO B 1 453 ? -3.306  59.310  -26.076 1.00 77.32  ? 453 PRO B CB  1 
ATOM   7475  C CG  . PRO B 1 453 ? -4.245  58.123  -26.212 1.00 79.53  ? 453 PRO B CG  1 
ATOM   7476  C CD  . PRO B 1 453 ? -3.315  56.916  -26.416 1.00 76.66  ? 453 PRO B CD  1 
ATOM   7477  N N   . LEU B 1 454 ? -1.800  60.169  -23.425 1.00 64.90  ? 454 LEU B N   1 
ATOM   7478  C CA  . LEU B 1 454 ? -1.608  60.509  -22.024 1.00 66.87  ? 454 LEU B CA  1 
ATOM   7479  C C   . LEU B 1 454 ? -2.775  59.988  -21.173 1.00 68.90  ? 454 LEU B C   1 
ATOM   7480  O O   . LEU B 1 454 ? -2.539  59.327  -20.160 1.00 59.91  ? 454 LEU B O   1 
ATOM   7481  C CB  . LEU B 1 454 ? -1.393  62.023  -21.904 1.00 62.79  ? 454 LEU B CB  1 
ATOM   7482  C CG  . LEU B 1 454 ? -1.207  62.593  -20.492 1.00 64.84  ? 454 LEU B CG  1 
ATOM   7483  C CD1 . LEU B 1 454 ? 0.142   62.237  -19.866 1.00 62.11  ? 454 LEU B CD1 1 
ATOM   7484  C CD2 . LEU B 1 454 ? -1.433  64.107  -20.496 1.00 68.81  ? 454 LEU B CD2 1 
ATOM   7485  N N   . TYR B 1 455 ? -4.030  60.230  -21.589 1.00 71.95  ? 455 TYR B N   1 
ATOM   7486  C CA  . TYR B 1 455 ? -5.170  59.964  -20.717 1.00 75.97  ? 455 TYR B CA  1 
ATOM   7487  C C   . TYR B 1 455 ? -5.260  58.461  -20.439 1.00 70.57  ? 455 TYR B C   1 
ATOM   7488  O O   . TYR B 1 455 ? -5.772  58.063  -19.391 1.00 66.18  ? 455 TYR B O   1 
ATOM   7489  C CB  . TYR B 1 455 ? -6.502  60.510  -21.255 1.00 85.53  ? 455 TYR B CB  1 
ATOM   7490  C CG  . TYR B 1 455 ? -7.358  59.553  -22.081 1.00 92.02  ? 455 TYR B CG  1 
ATOM   7491  C CD1 . TYR B 1 455 ? -7.102  59.357  -23.438 1.00 95.11  ? 455 TYR B CD1 1 
ATOM   7492  C CD2 . TYR B 1 455 ? -8.437  58.872  -21.513 1.00 87.61  ? 455 TYR B CD2 1 
ATOM   7493  C CE1 . TYR B 1 455 ? -7.876  58.497  -24.198 1.00 100.47 ? 455 TYR B CE1 1 
ATOM   7494  C CE2 . TYR B 1 455 ? -9.215  58.003  -22.263 1.00 86.83  ? 455 TYR B CE2 1 
ATOM   7495  C CZ  . TYR B 1 455 ? -8.930  57.821  -23.607 1.00 101.89 ? 455 TYR B CZ  1 
ATOM   7496  O OH  . TYR B 1 455 ? -9.665  56.980  -24.385 1.00 119.91 ? 455 TYR B OH  1 
ATOM   7497  N N   . LEU B 1 456 ? -4.759  57.648  -21.382 1.00 66.43  ? 456 LEU B N   1 
ATOM   7498  C CA  . LEU B 1 456 ? -4.767  56.198  -21.258 1.00 69.00  ? 456 LEU B CA  1 
ATOM   7499  C C   . LEU B 1 456 ? -3.525  55.708  -20.506 1.00 66.20  ? 456 LEU B C   1 
ATOM   7500  O O   . LEU B 1 456 ? -3.585  54.722  -19.768 1.00 59.45  ? 456 LEU B O   1 
ATOM   7501  C CB  . LEU B 1 456 ? -4.876  55.590  -22.655 1.00 72.18  ? 456 LEU B CB  1 
ATOM   7502  C CG  . LEU B 1 456 ? -5.323  54.123  -22.722 1.00 81.91  ? 456 LEU B CG  1 
ATOM   7503  C CD1 . LEU B 1 456 ? -6.742  53.925  -22.187 1.00 77.49  ? 456 LEU B CD1 1 
ATOM   7504  C CD2 . LEU B 1 456 ? -5.217  53.580  -24.148 1.00 81.44  ? 456 LEU B CD2 1 
ATOM   7505  N N   . VAL B 1 457 ? -2.388  56.396  -20.659 1.00 59.17  ? 457 VAL B N   1 
ATOM   7506  C CA  . VAL B 1 457 ? -1.245  56.074  -19.817 1.00 61.71  ? 457 VAL B CA  1 
ATOM   7507  C C   . VAL B 1 457 ? -1.683  56.214  -18.360 1.00 59.00  ? 457 VAL B C   1 
ATOM   7508  O O   . VAL B 1 457 ? -1.308  55.410  -17.513 1.00 56.87  ? 457 VAL B O   1 
ATOM   7509  C CB  . VAL B 1 457 ? 0.028   56.893  -20.100 1.00 60.10  ? 457 VAL B CB  1 
ATOM   7510  C CG1 . VAL B 1 457 ? 1.091   56.705  -19.016 1.00 60.06  ? 457 VAL B CG1 1 
ATOM   7511  C CG2 . VAL B 1 457 ? 0.598   56.554  -21.469 1.00 62.14  ? 457 VAL B CG2 1 
ATOM   7512  N N   . ARG B 1 458 ? -2.497  57.230  -18.082 1.00 58.99  ? 458 ARG B N   1 
ATOM   7513  C CA  . ARG B 1 458 ? -2.922  57.505  -16.724 1.00 65.05  ? 458 ARG B CA  1 
ATOM   7514  C C   . ARG B 1 458 ? -3.730  56.340  -16.166 1.00 64.37  ? 458 ARG B C   1 
ATOM   7515  O O   . ARG B 1 458 ? -3.484  55.919  -15.039 1.00 64.44  ? 458 ARG B O   1 
ATOM   7516  C CB  . ARG B 1 458 ? -3.714  58.812  -16.674 1.00 58.64  ? 458 ARG B CB  1 
ATOM   7517  C CG  . ARG B 1 458 ? -2.785  59.989  -16.900 1.00 52.44  ? 458 ARG B CG  1 
ATOM   7518  C CD  . ARG B 1 458 ? -3.576  61.243  -16.659 1.00 55.53  ? 458 ARG B CD  1 
ATOM   7519  N NE  . ARG B 1 458 ? -2.677  62.395  -16.535 1.00 55.78  ? 458 ARG B NE  1 
ATOM   7520  C CZ  . ARG B 1 458 ? -2.869  63.571  -17.113 1.00 56.43  ? 458 ARG B CZ  1 
ATOM   7521  N NH1 . ARG B 1 458 ? -3.905  63.777  -17.911 1.00 57.36  ? 458 ARG B NH1 1 
ATOM   7522  N NH2 . ARG B 1 458 ? -2.001  64.539  -16.908 1.00 61.01  ? 458 ARG B NH2 1 
ATOM   7523  N N   . LEU B 1 459 ? -4.689  55.838  -16.952 1.00 69.50  ? 459 LEU B N   1 
ATOM   7524  C CA  . LEU B 1 459 ? -5.613  54.824  -16.465 1.00 78.14  ? 459 LEU B CA  1 
ATOM   7525  C C   . LEU B 1 459 ? -4.914  53.461  -16.424 1.00 72.39  ? 459 LEU B C   1 
ATOM   7526  O O   . LEU B 1 459 ? -5.094  52.710  -15.470 1.00 71.37  ? 459 LEU B O   1 
ATOM   7527  C CB  . LEU B 1 459 ? -6.912  54.846  -17.279 1.00 85.67  ? 459 LEU B CB  1 
ATOM   7528  C CG  . LEU B 1 459 ? -7.698  56.170  -17.241 1.00 101.22 ? 459 LEU B CG  1 
ATOM   7529  C CD1 . LEU B 1 459 ? -9.137  56.019  -17.710 1.00 102.86 ? 459 LEU B CD1 1 
ATOM   7530  C CD2 . LEU B 1 459 ? -7.696  56.840  -15.864 1.00 103.60 ? 459 LEU B CD2 1 
ATOM   7531  N N   . LEU B 1 460 ? -4.046  53.184  -17.405 1.00 70.34  ? 460 LEU B N   1 
ATOM   7532  C CA  . LEU B 1 460 ? -3.240  51.969  -17.415 1.00 72.91  ? 460 LEU B CA  1 
ATOM   7533  C C   . LEU B 1 460 ? -2.279  51.923  -16.221 1.00 68.99  ? 460 LEU B C   1 
ATOM   7534  O O   . LEU B 1 460 ? -1.926  50.842  -15.746 1.00 67.28  ? 460 LEU B O   1 
ATOM   7535  C CB  . LEU B 1 460 ? -2.466  51.864  -18.732 1.00 78.77  ? 460 LEU B CB  1 
ATOM   7536  C CG  . LEU B 1 460 ? -3.295  51.679  -20.012 1.00 80.57  ? 460 LEU B CG  1 
ATOM   7537  C CD1 . LEU B 1 460 ? -2.342  51.636  -21.201 1.00 73.50  ? 460 LEU B CD1 1 
ATOM   7538  C CD2 . LEU B 1 460 ? -4.208  50.450  -19.987 1.00 72.58  ? 460 LEU B CD2 1 
ATOM   7539  N N   . THR B 1 461 ? -1.830  53.095  -15.760 1.00 64.45  ? 461 THR B N   1 
ATOM   7540  C CA  . THR B 1 461 ? -0.884  53.184  -14.659 1.00 63.90  ? 461 THR B CA  1 
ATOM   7541  C C   . THR B 1 461 ? -1.547  52.630  -13.397 1.00 59.61  ? 461 THR B C   1 
ATOM   7542  O O   . THR B 1 461 ? -0.947  51.844  -12.665 1.00 55.28  ? 461 THR B O   1 
ATOM   7543  C CB  . THR B 1 461 ? -0.404  54.635  -14.495 1.00 62.34  ? 461 THR B CB  1 
ATOM   7544  O OG1 . THR B 1 461 ? 0.347   55.012  -15.654 1.00 58.62  ? 461 THR B OG1 1 
ATOM   7545  C CG2 . THR B 1 461 ? 0.484   54.839  -13.278 1.00 61.55  ? 461 THR B CG2 1 
ATOM   7546  N N   . MET B 1 462 ? -2.802  53.023  -13.156 1.00 57.93  ? 462 MET B N   1 
ATOM   7547  C CA  . MET B 1 462 ? -3.463  52.656  -11.919 1.00 65.41  ? 462 MET B CA  1 
ATOM   7548  C C   . MET B 1 462 ? -3.959  51.211  -11.995 1.00 70.73  ? 462 MET B C   1 
ATOM   7549  O O   . MET B 1 462 ? -4.317  50.646  -10.959 1.00 66.04  ? 462 MET B O   1 
ATOM   7550  C CB  . MET B 1 462 ? -4.611  53.619  -11.586 1.00 65.45  ? 462 MET B CB  1 
ATOM   7551  C CG  . MET B 1 462 ? -4.183  55.073  -11.401 1.00 61.62  ? 462 MET B CG  1 
ATOM   7552  S SD  . MET B 1 462 ? -2.629  55.303  -10.510 1.00 57.33  ? 462 MET B SD  1 
ATOM   7553  C CE  . MET B 1 462 ? -3.098  54.524  -8.957  1.00 65.62  ? 462 MET B CE  1 
ATOM   7554  N N   . GLN B 1 463 ? -3.957  50.620  -13.206 1.00 71.59  ? 463 GLN B N   1 
ATOM   7555  C CA  . GLN B 1 463 ? -4.314  49.215  -13.385 1.00 72.82  ? 463 GLN B CA  1 
ATOM   7556  C C   . GLN B 1 463 ? -3.103  48.310  -13.141 1.00 62.59  ? 463 GLN B C   1 
ATOM   7557  O O   . GLN B 1 463 ? -3.286  47.124  -12.927 1.00 68.42  ? 463 GLN B O   1 
ATOM   7558  C CB  . GLN B 1 463 ? -5.005  48.927  -14.727 1.00 73.28  ? 463 GLN B CB  1 
ATOM   7559  C CG  . GLN B 1 463 ? -6.467  49.380  -14.782 1.00 72.25  ? 463 GLN B CG  1 
ATOM   7560  C CD  . GLN B 1 463 ? -7.110  49.291  -16.156 1.00 78.21  ? 463 GLN B CD  1 
ATOM   7561  O OE1 . GLN B 1 463 ? -6.493  48.899  -17.153 1.00 81.95  ? 463 GLN B OE1 1 
ATOM   7562  N NE2 . GLN B 1 463 ? -8.385  49.648  -16.234 1.00 85.55  ? 463 GLN B NE2 1 
ATOM   7563  N N   . ARG B 1 464 ? -1.881  48.859  -13.104 1.00 64.59  ? 464 ARG B N   1 
ATOM   7564  C CA  . ARG B 1 464 ? -0.684  48.056  -12.874 1.00 64.60  ? 464 ARG B CA  1 
ATOM   7565  C C   . ARG B 1 464 ? -0.566  47.588  -11.425 1.00 65.53  ? 464 ARG B C   1 
ATOM   7566  O O   . ARG B 1 464 ? -0.940  48.290  -10.484 1.00 68.85  ? 464 ARG B O   1 
ATOM   7567  C CB  . ARG B 1 464 ? 0.615   48.798  -13.192 1.00 68.89  ? 464 ARG B CB  1 
ATOM   7568  C CG  . ARG B 1 464 ? 0.661   49.324  -14.616 1.00 76.41  ? 464 ARG B CG  1 
ATOM   7569  C CD  . ARG B 1 464 ? 2.022   49.897  -14.934 1.00 84.79  ? 464 ARG B CD  1 
ATOM   7570  N NE  . ARG B 1 464 ? 2.984   48.811  -15.149 1.00 93.31  ? 464 ARG B NE  1 
ATOM   7571  C CZ  . ARG B 1 464 ? 3.809   48.691  -16.185 1.00 86.10  ? 464 ARG B CZ  1 
ATOM   7572  N NH1 . ARG B 1 464 ? 3.814   49.570  -17.174 1.00 76.51  ? 464 ARG B NH1 1 
ATOM   7573  N NH2 . ARG B 1 464 ? 4.656   47.683  -16.208 1.00 86.10  ? 464 ARG B NH2 1 
ATOM   7574  N N   . THR B 1 465 ? 0.036   46.406  -11.277 1.00 67.12  ? 465 THR B N   1 
ATOM   7575  C CA  . THR B 1 465 ? 0.089   45.678  -10.020 1.00 73.37  ? 465 THR B CA  1 
ATOM   7576  C C   . THR B 1 465 ? 0.865   46.473  -8.963  1.00 69.57  ? 465 THR B C   1 
ATOM   7577  O O   . THR B 1 465 ? 0.466   46.493  -7.798  1.00 67.04  ? 465 THR B O   1 
ATOM   7578  C CB  . THR B 1 465 ? 0.676   44.282  -10.271 1.00 78.20  ? 465 THR B CB  1 
ATOM   7579  O OG1 . THR B 1 465 ? 0.824   43.758  -8.959  1.00 74.59  ? 465 THR B OG1 1 
ATOM   7580  C CG2 . THR B 1 465 ? 2.042   44.269  -10.940 1.00 79.48  ? 465 THR B CG2 1 
ATOM   7581  N N   . GLU B 1 466 ? 1.950   47.144  -9.377  1.00 61.52  ? 466 GLU B N   1 
ATOM   7582  C CA  . GLU B 1 466 ? 2.803   47.902  -8.474  1.00 68.68  ? 466 GLU B CA  1 
ATOM   7583  C C   . GLU B 1 466 ? 2.053   49.057  -7.806  1.00 66.12  ? 466 GLU B C   1 
ATOM   7584  O O   . GLU B 1 466 ? 2.502   49.542  -6.775  1.00 70.23  ? 466 GLU B O   1 
ATOM   7585  C CB  . GLU B 1 466 ? 4.022   48.497  -9.186  1.00 80.68  ? 466 GLU B CB  1 
ATOM   7586  C CG  . GLU B 1 466 ? 4.987   47.459  -9.760  1.00 87.90  ? 466 GLU B CG  1 
ATOM   7587  C CD  . GLU B 1 466 ? 4.778   47.003  -11.206 1.00 81.76  ? 466 GLU B CD  1 
ATOM   7588  O OE1 . GLU B 1 466 ? 5.813   46.858  -11.917 1.00 68.54  ? 466 GLU B OE1 1 
ATOM   7589  O OE2 . GLU B 1 466 ? 3.609   46.783  -11.622 1.00 69.96  ? 466 GLU B OE2 1 
ATOM   7590  N N   . TYR B 1 467 ? 0.922   49.495  -8.382  1.00 66.12  ? 467 TYR B N   1 
ATOM   7591  C CA  . TYR B 1 467 ? 0.246   50.713  -7.949  1.00 58.07  ? 467 TYR B CA  1 
ATOM   7592  C C   . TYR B 1 467 ? -1.165  50.422  -7.424  1.00 56.42  ? 467 TYR B C   1 
ATOM   7593  O O   . TYR B 1 467 ? -1.999  51.320  -7.313  1.00 57.28  ? 467 TYR B O   1 
ATOM   7594  C CB  . TYR B 1 467 ? 0.274   51.673  -9.146  1.00 52.47  ? 467 TYR B CB  1 
ATOM   7595  C CG  . TYR B 1 467 ? 1.671   52.000  -9.671  1.00 51.96  ? 467 TYR B CG  1 
ATOM   7596  C CD1 . TYR B 1 467 ? 2.725   52.284  -8.808  1.00 48.04  ? 467 TYR B CD1 1 
ATOM   7597  C CD2 . TYR B 1 467 ? 1.944   51.997  -11.032 1.00 49.81  ? 467 TYR B CD2 1 
ATOM   7598  C CE1 . TYR B 1 467 ? 3.993   52.568  -9.279  1.00 52.10  ? 467 TYR B CE1 1 
ATOM   7599  C CE2 . TYR B 1 467 ? 3.210   52.277  -11.520 1.00 49.41  ? 467 TYR B CE2 1 
ATOM   7600  C CZ  . TYR B 1 467 ? 4.233   52.575  -10.643 1.00 54.55  ? 467 TYR B CZ  1 
ATOM   7601  O OH  . TYR B 1 467 ? 5.472   52.870  -11.136 1.00 58.01  ? 467 TYR B OH  1 
ATOM   7602  N N   . GLN B 1 468 ? -1.426  49.174  -7.030  1.00 59.13  ? 468 GLN B N   1 
ATOM   7603  C CA  . GLN B 1 468 ? -2.696  48.841  -6.400  1.00 58.66  ? 468 GLN B CA  1 
ATOM   7604  C C   . GLN B 1 468 ? -2.673  49.312  -4.950  1.00 54.84  ? 468 GLN B C   1 
ATOM   7605  O O   . GLN B 1 468 ? -1.599  49.514  -4.373  1.00 50.67  ? 468 GLN B O   1 
ATOM   7606  C CB  . GLN B 1 468 ? -2.970  47.334  -6.470  1.00 64.90  ? 468 GLN B CB  1 
ATOM   7607  C CG  . GLN B 1 468 ? -3.137  46.809  -7.892  1.00 66.22  ? 468 GLN B CG  1 
ATOM   7608  C CD  . GLN B 1 468 ? -4.169  47.608  -8.660  1.00 73.48  ? 468 GLN B CD  1 
ATOM   7609  O OE1 . GLN B 1 468 ? -5.383  47.475  -8.440  1.00 67.93  ? 468 GLN B OE1 1 
ATOM   7610  N NE2 . GLN B 1 468 ? -3.679  48.485  -9.530  1.00 68.83  ? 468 GLN B NE2 1 
ATOM   7611  N N   . VAL B 1 469 ? -3.876  49.441  -4.373  1.00 55.58  ? 469 VAL B N   1 
ATOM   7612  C CA  . VAL B 1 469 ? -4.048  49.778  -2.966  1.00 56.80  ? 469 VAL B CA  1 
ATOM   7613  C C   . VAL B 1 469 ? -3.211  48.852  -2.079  1.00 63.22  ? 469 VAL B C   1 
ATOM   7614  O O   . VAL B 1 469 ? -2.544  49.341  -1.166  1.00 64.31  ? 469 VAL B O   1 
ATOM   7615  C CB  . VAL B 1 469 ? -5.525  49.732  -2.542  1.00 54.68  ? 469 VAL B CB  1 
ATOM   7616  C CG1 . VAL B 1 469 ? -5.714  50.388  -1.180  1.00 60.39  ? 469 VAL B CG1 1 
ATOM   7617  C CG2 . VAL B 1 469 ? -6.429  50.384  -3.579  1.00 62.02  ? 469 VAL B CG2 1 
ATOM   7618  N N   . ASP B 1 470 ? -3.252  47.528  -2.340  1.00 64.56  ? 470 ASP B N   1 
ATOM   7619  C CA  . ASP B 1 470 ? -2.502  46.542  -1.565  1.00 64.67  ? 470 ASP B CA  1 
ATOM   7620  C C   . ASP B 1 470 ? -1.108  46.274  -2.132  1.00 65.59  ? 470 ASP B C   1 
ATOM   7621  O O   . ASP B 1 470 ? -0.408  45.382  -1.654  1.00 72.51  ? 470 ASP B O   1 
ATOM   7622  C CB  . ASP B 1 470 ? -3.260  45.230  -1.462  1.00 66.98  ? 470 ASP B CB  1 
ATOM   7623  C CG  . ASP B 1 470 ? -4.389  45.271  -0.448  1.00 72.93  ? 470 ASP B CG  1 
ATOM   7624  O OD1 . ASP B 1 470 ? -4.098  45.633  0.711   1.00 84.66  ? 470 ASP B OD1 1 
ATOM   7625  O OD2 . ASP B 1 470 ? -5.544  44.970  -0.828  1.00 72.22  ? 470 ASP B OD2 1 
ATOM   7626  N N   . GLY B 1 471 ? -0.703  47.038  -3.149  1.00 59.07  ? 471 GLY B N   1 
ATOM   7627  C CA  . GLY B 1 471 ? 0.606   46.877  -3.752  1.00 58.22  ? 471 GLY B CA  1 
ATOM   7628  C C   . GLY B 1 471 ? 1.706   47.439  -2.855  1.00 54.81  ? 471 GLY B C   1 
ATOM   7629  O O   . GLY B 1 471 ? 1.436   47.993  -1.786  1.00 51.97  ? 471 GLY B O   1 
ATOM   7630  N N   . PRO B 1 472 ? 2.983   47.310  -3.275  1.00 54.77  ? 472 PRO B N   1 
ATOM   7631  C CA  . PRO B 1 472 ? 4.109   47.792  -2.472  1.00 62.64  ? 472 PRO B CA  1 
ATOM   7632  C C   . PRO B 1 472 ? 4.204   49.314  -2.351  1.00 60.41  ? 472 PRO B C   1 
ATOM   7633  O O   . PRO B 1 472 ? 4.973   49.819  -1.549  1.00 55.64  ? 472 PRO B O   1 
ATOM   7634  C CB  . PRO B 1 472 ? 5.357   47.183  -3.169  1.00 62.82  ? 472 PRO B CB  1 
ATOM   7635  C CG  . PRO B 1 472 ? 4.916   46.939  -4.604  1.00 64.62  ? 472 PRO B CG  1 
ATOM   7636  C CD  . PRO B 1 472 ? 3.403   46.694  -4.544  1.00 62.77  ? 472 PRO B CD  1 
ATOM   7637  N N   . LEU B 1 473 ? 3.412   50.061  -3.123  1.00 62.10  ? 473 LEU B N   1 
ATOM   7638  C CA  . LEU B 1 473 ? 3.542   51.503  -3.058  1.00 66.61  ? 473 LEU B CA  1 
ATOM   7639  C C   . LEU B 1 473 ? 2.788   52.065  -1.847  1.00 60.88  ? 473 LEU B C   1 
ATOM   7640  O O   . LEU B 1 473 ? 2.968   53.242  -1.551  1.00 58.30  ? 473 LEU B O   1 
ATOM   7641  C CB  . LEU B 1 473 ? 3.115   52.162  -4.371  1.00 66.54  ? 473 LEU B CB  1 
ATOM   7642  C CG  . LEU B 1 473 ? 3.686   53.564  -4.618  1.00 64.36  ? 473 LEU B CG  1 
ATOM   7643  C CD1 . LEU B 1 473 ? 5.195   53.597  -4.552  1.00 68.08  ? 473 LEU B CD1 1 
ATOM   7644  C CD2 . LEU B 1 473 ? 3.256   54.100  -5.960  1.00 76.40  ? 473 LEU B CD2 1 
ATOM   7645  N N   . THR B 1 474 ? 1.978   51.244  -1.142  1.00 53.89  ? 474 THR B N   1 
ATOM   7646  C CA  . THR B 1 474 ? 1.327   51.680  0.091   1.00 57.24  ? 474 THR B CA  1 
ATOM   7647  C C   . THR B 1 474 ? 2.065   51.182  1.331   1.00 56.47  ? 474 THR B C   1 
ATOM   7648  O O   . THR B 1 474 ? 1.601   51.434  2.446   1.00 57.18  ? 474 THR B O   1 
ATOM   7649  C CB  . THR B 1 474 ? -0.135  51.242  0.159   1.00 56.72  ? 474 THR B CB  1 
ATOM   7650  O OG1 . THR B 1 474 ? -0.166  49.837  -0.089  1.00 66.19  ? 474 THR B OG1 1 
ATOM   7651  C CG2 . THR B 1 474 ? -1.000  52.029  -0.808  1.00 59.13  ? 474 THR B CG2 1 
ATOM   7652  N N   . ASP B 1 475 ? 3.204   50.498  1.146   1.00 58.27  ? 475 ASP B N   1 
ATOM   7653  C CA  . ASP B 1 475 ? 3.883   49.846  2.255   1.00 58.04  ? 475 ASP B CA  1 
ATOM   7654  C C   . ASP B 1 475 ? 4.336   50.904  3.249   1.00 56.17  ? 475 ASP B C   1 
ATOM   7655  O O   . ASP B 1 475 ? 4.065   50.778  4.441   1.00 56.76  ? 475 ASP B O   1 
ATOM   7656  C CB  . ASP B 1 475 ? 5.065   48.989  1.830   1.00 61.35  ? 475 ASP B CB  1 
ATOM   7657  C CG  . ASP B 1 475 ? 4.728   47.650  1.197   1.00 66.43  ? 475 ASP B CG  1 
ATOM   7658  O OD1 . ASP B 1 475 ? 3.636   47.117  1.493   1.00 62.44  ? 475 ASP B OD1 1 
ATOM   7659  O OD2 . ASP B 1 475 ? 5.559   47.169  0.396   1.00 72.27  ? 475 ASP B OD2 1 
ATOM   7660  N N   . LEU B 1 476 ? 5.014   51.939  2.744   1.00 56.40  ? 476 LEU B N   1 
ATOM   7661  C CA  . LEU B 1 476 ? 5.537   52.981  3.612   1.00 54.56  ? 476 LEU B CA  1 
ATOM   7662  C C   . LEU B 1 476 ? 4.392   53.665  4.354   1.00 49.20  ? 476 LEU B C   1 
ATOM   7663  O O   . LEU B 1 476 ? 4.464   53.864  5.565   1.00 50.24  ? 476 LEU B O   1 
ATOM   7664  C CB  . LEU B 1 476 ? 6.367   53.994  2.839   1.00 56.75  ? 476 LEU B CB  1 
ATOM   7665  C CG  . LEU B 1 476 ? 6.939   55.126  3.693   1.00 58.63  ? 476 LEU B CG  1 
ATOM   7666  C CD1 . LEU B 1 476 ? 7.850   54.566  4.787   1.00 52.92  ? 476 LEU B CD1 1 
ATOM   7667  C CD2 . LEU B 1 476 ? 7.642   56.115  2.769   1.00 57.91  ? 476 LEU B CD2 1 
ATOM   7668  N N   . ALA B 1 477 ? 3.318   53.974  3.629   1.00 46.96  ? 477 ALA B N   1 
ATOM   7669  C CA  . ALA B 1 477 ? 2.196   54.677  4.223   1.00 53.30  ? 477 ALA B CA  1 
ATOM   7670  C C   . ALA B 1 477 ? 1.530   53.806  5.291   1.00 50.85  ? 477 ALA B C   1 
ATOM   7671  O O   . ALA B 1 477 ? 1.173   54.313  6.354   1.00 45.52  ? 477 ALA B O   1 
ATOM   7672  C CB  . ALA B 1 477 ? 1.231   55.136  3.141   1.00 53.72  ? 477 ALA B CB  1 
ATOM   7673  N N   . ARG B 1 478 ? 1.409   52.498  5.013   1.00 54.27  ? 478 ARG B N   1 
ATOM   7674  C CA  . ARG B 1 478 ? 0.738   51.572  5.918   1.00 54.18  ? 478 ARG B CA  1 
ATOM   7675  C C   . ARG B 1 478 ? 1.501   51.461  7.234   1.00 46.01  ? 478 ARG B C   1 
ATOM   7676  O O   . ARG B 1 478 ? 0.884   51.411  8.295   1.00 46.58  ? 478 ARG B O   1 
ATOM   7677  C CB  . ARG B 1 478 ? 0.593   50.159  5.332   1.00 56.48  ? 478 ARG B CB  1 
ATOM   7678  C CG  . ARG B 1 478 ? -0.573  49.939  4.379   1.00 62.32  ? 478 ARG B CG  1 
ATOM   7679  C CD  . ARG B 1 478 ? -0.534  48.601  3.605   1.00 61.27  ? 478 ARG B CD  1 
ATOM   7680  N NE  . ARG B 1 478 ? -1.459  48.582  2.462   1.00 63.79  ? 478 ARG B NE  1 
ATOM   7681  C CZ  . ARG B 1 478 ? -2.812  48.636  2.491   1.00 76.08  ? 478 ARG B CZ  1 
ATOM   7682  N NH1 . ARG B 1 478 ? -3.513  48.627  3.632   1.00 63.94  ? 478 ARG B NH1 1 
ATOM   7683  N NH2 . ARG B 1 478 ? -3.472  48.695  1.340   1.00 79.91  ? 478 ARG B NH2 1 
ATOM   7684  N N   . GLN B 1 479 ? 2.829   51.360  7.135   1.00 48.81  ? 479 GLN B N   1 
ATOM   7685  C CA  . GLN B 1 479 ? 3.712   51.305  8.289   1.00 57.84  ? 479 GLN B CA  1 
ATOM   7686  C C   . GLN B 1 479 ? 3.533   52.546  9.154   1.00 59.20  ? 479 GLN B C   1 
ATOM   7687  O O   . GLN B 1 479 ? 3.500   52.441  10.372  1.00 71.54  ? 479 GLN B O   1 
ATOM   7688  C CB  . GLN B 1 479 ? 5.196   51.337  7.925   1.00 60.98  ? 479 GLN B CB  1 
ATOM   7689  C CG  . GLN B 1 479 ? 5.779   50.012  7.451   1.00 71.50  ? 479 GLN B CG  1 
ATOM   7690  C CD  . GLN B 1 479 ? 7.273   50.110  7.209   1.00 86.31  ? 479 GLN B CD  1 
ATOM   7691  O OE1 . GLN B 1 479 ? 8.011   50.767  7.958   1.00 82.45  ? 479 GLN B OE1 1 
ATOM   7692  N NE2 . GLN B 1 479 ? 7.731   49.498  6.126   1.00 91.98  ? 479 GLN B NE2 1 
ATOM   7693  N N   . VAL B 1 480 ? 3.471   53.710  8.501   1.00 53.65  ? 480 VAL B N   1 
ATOM   7694  C CA  . VAL B 1 480 ? 3.352   54.996  9.162   1.00 55.77  ? 480 VAL B CA  1 
ATOM   7695  C C   . VAL B 1 480 ? 2.051   55.067  9.964   1.00 55.50  ? 480 VAL B C   1 
ATOM   7696  O O   . VAL B 1 480 ? 2.047   55.578  11.078  1.00 54.85  ? 480 VAL B O   1 
ATOM   7697  C CB  . VAL B 1 480 ? 3.451   56.109  8.093   1.00 59.04  ? 480 VAL B CB  1 
ATOM   7698  C CG1 . VAL B 1 480 ? 2.625   57.344  8.419   1.00 52.89  ? 480 VAL B CG1 1 
ATOM   7699  C CG2 . VAL B 1 480 ? 4.902   56.486  7.810   1.00 61.16  ? 480 VAL B CG2 1 
ATOM   7700  N N   . LEU B 1 481 ? 0.952   54.562  9.392   1.00 54.64  ? 481 LEU B N   1 
ATOM   7701  C CA  . LEU B 1 481 ? -0.344  54.544  10.056  1.00 57.56  ? 481 LEU B CA  1 
ATOM   7702  C C   . LEU B 1 481 ? -0.514  53.353  11.004  1.00 58.85  ? 481 LEU B C   1 
ATOM   7703  O O   . LEU B 1 481 ? -1.459  53.370  11.798  1.00 54.50  ? 481 LEU B O   1 
ATOM   7704  C CB  . LEU B 1 481 ? -1.397  54.482  8.952   1.00 59.18  ? 481 LEU B CB  1 
ATOM   7705  C CG  . LEU B 1 481 ? -1.624  55.786  8.185   1.00 63.41  ? 481 LEU B CG  1 
ATOM   7706  C CD1 . LEU B 1 481 ? -2.217  55.527  6.808   1.00 63.18  ? 481 LEU B CD1 1 
ATOM   7707  C CD2 . LEU B 1 481 ? -2.513  56.699  9.016   1.00 59.93  ? 481 LEU B CD2 1 
ATOM   7708  N N   . GLY B 1 482 ? 0.352   52.325  10.867  1.00 55.37  ? 482 GLY B N   1 
ATOM   7709  C CA  . GLY B 1 482 ? 0.232   51.043  11.554  1.00 59.35  ? 482 GLY B CA  1 
ATOM   7710  C C   . GLY B 1 482 ? -1.071  50.312  11.207  1.00 65.95  ? 482 GLY B C   1 
ATOM   7711  O O   . GLY B 1 482 ? -1.960  50.253  12.048  1.00 70.22  ? 482 GLY B O   1 
ATOM   7712  N N   . PHE B 1 483 ? -1.195  49.727  9.999   1.00 68.56  ? 483 PHE B N   1 
ATOM   7713  C CA  . PHE B 1 483 ? -2.523  49.386  9.489   1.00 81.35  ? 483 PHE B CA  1 
ATOM   7714  C C   . PHE B 1 483 ? -2.775  47.880  9.335   1.00 83.82  ? 483 PHE B C   1 
ATOM   7715  O O   . PHE B 1 483 ? -3.714  47.347  9.958   1.00 70.35  ? 483 PHE B O   1 
ATOM   7716  C CB  . PHE B 1 483 ? -2.793  50.166  8.191   1.00 80.25  ? 483 PHE B CB  1 
ATOM   7717  C CG  . PHE B 1 483 ? -3.749  51.352  8.337   1.00 71.48  ? 483 PHE B CG  1 
ATOM   7718  C CD1 . PHE B 1 483 ? -4.230  52.012  7.211   1.00 63.83  ? 483 PHE B CD1 1 
ATOM   7719  C CD2 . PHE B 1 483 ? -4.191  51.792  9.590   1.00 66.66  ? 483 PHE B CD2 1 
ATOM   7720  C CE1 . PHE B 1 483 ? -5.100  53.087  7.333   1.00 64.28  ? 483 PHE B CE1 1 
ATOM   7721  C CE2 . PHE B 1 483 ? -5.059  52.866  9.705   1.00 65.91  ? 483 PHE B CE2 1 
ATOM   7722  C CZ  . PHE B 1 483 ? -5.516  53.509  8.575   1.00 64.33  ? 483 PHE B CZ  1 
ATOM   7723  N N   . GLY B 1 484 ? -1.970  47.231  8.478   1.00 74.93  ? 484 GLY B N   1 
ATOM   7724  C CA  . GLY B 1 484 ? -2.319  45.950  7.880   1.00 74.87  ? 484 GLY B CA  1 
ATOM   7725  C C   . GLY B 1 484 ? -2.653  46.163  6.408   1.00 78.91  ? 484 GLY B C   1 
ATOM   7726  O O   . GLY B 1 484 ? -2.421  47.260  5.906   1.00 89.71  ? 484 GLY B O   1 
ATOM   7727  N N   . ASP B 1 485 ? -3.187  45.132  5.725   1.00 87.67  ? 485 ASP B N   1 
ATOM   7728  C CA  . ASP B 1 485 ? -3.667  45.256  4.345   1.00 77.20  ? 485 ASP B CA  1 
ATOM   7729  C C   . ASP B 1 485 ? -5.175  45.551  4.366   1.00 70.42  ? 485 ASP B C   1 
ATOM   7730  O O   . ASP B 1 485 ? -5.755  45.662  5.449   1.00 62.49  ? 485 ASP B O   1 
ATOM   7731  C CB  . ASP B 1 485 ? -3.185  44.101  3.466   1.00 79.44  ? 485 ASP B CB  1 
ATOM   7732  C CG  . ASP B 1 485 ? -3.923  42.763  3.537   1.00 82.09  ? 485 ASP B CG  1 
ATOM   7733  O OD1 . ASP B 1 485 ? -4.180  42.274  4.665   1.00 82.32  ? 485 ASP B OD1 1 
ATOM   7734  O OD2 . ASP B 1 485 ? -4.210  42.193  2.451   1.00 82.01  ? 485 ASP B OD2 1 
ATOM   7735  N N   . THR B 1 486 ? -5.786  45.721  3.171   1.00 72.72  ? 486 THR B N   1 
ATOM   7736  C CA  . THR B 1 486 ? -7.213  45.992  2.996   1.00 71.50  ? 486 THR B CA  1 
ATOM   7737  C C   . THR B 1 486 ? -8.045  45.060  3.881   1.00 83.40  ? 486 THR B C   1 
ATOM   7738  O O   . THR B 1 486 ? -8.952  45.513  4.583   1.00 86.83  ? 486 THR B O   1 
ATOM   7739  C CB  . THR B 1 486 ? -7.592  45.834  1.519   1.00 76.23  ? 486 THR B CB  1 
ATOM   7740  O OG1 . THR B 1 486 ? -6.777  46.755  0.803   1.00 81.91  ? 486 THR B OG1 1 
ATOM   7741  C CG2 . THR B 1 486 ? -9.048  46.152  1.212   1.00 79.13  ? 486 THR B CG2 1 
ATOM   7742  N N   . GLU B 1 487 ? -7.696  43.762  3.843   1.00 92.28  ? 487 GLU B N   1 
ATOM   7743  C CA  . GLU B 1 487 ? -8.433  42.692  4.504   1.00 98.16  ? 487 GLU B CA  1 
ATOM   7744  C C   . GLU B 1 487 ? -8.239  42.762  6.024   1.00 83.03  ? 487 GLU B C   1 
ATOM   7745  O O   . GLU B 1 487 ? -9.164  42.467  6.783   1.00 78.31  ? 487 GLU B O   1 
ATOM   7746  C CB  . GLU B 1 487 ? -8.023  41.385  3.807   1.00 109.55 ? 487 GLU B CB  1 
ATOM   7747  C CG  . GLU B 1 487 ? -8.497  40.105  4.494   1.00 122.64 ? 487 GLU B CG  1 
ATOM   7748  C CD  . GLU B 1 487 ? -7.512  39.538  5.506   1.00 148.46 ? 487 GLU B CD  1 
ATOM   7749  O OE1 . GLU B 1 487 ? -6.400  39.147  5.088   1.00 168.07 ? 487 GLU B OE1 1 
ATOM   7750  O OE2 . GLU B 1 487 ? -7.846  39.493  6.709   1.00 155.89 ? 487 GLU B OE2 1 
ATOM   7751  N N   . ALA B 1 488 ? -7.037  43.146  6.470   1.00 78.12  ? 488 ALA B N   1 
ATOM   7752  C CA  . ALA B 1 488 ? -6.740  43.253  7.891   1.00 83.82  ? 488 ALA B CA  1 
ATOM   7753  C C   . ALA B 1 488 ? -7.469  44.457  8.495   1.00 84.49  ? 488 ALA B C   1 
ATOM   7754  O O   . ALA B 1 488 ? -7.877  44.400  9.651   1.00 90.66  ? 488 ALA B O   1 
ATOM   7755  C CB  . ALA B 1 488 ? -5.239  43.334  8.090   1.00 82.92  ? 488 ALA B CB  1 
ATOM   7756  N N   . LEU B 1 489 ? -7.611  45.534  7.697   1.00 82.46  ? 489 LEU B N   1 
ATOM   7757  C CA  . LEU B 1 489 ? -8.347  46.749  8.051   1.00 78.00  ? 489 LEU B CA  1 
ATOM   7758  C C   . LEU B 1 489 ? -9.854  46.506  8.022   1.00 70.89  ? 489 LEU B C   1 
ATOM   7759  O O   . LEU B 1 489 ? -10.574 46.972  8.897   1.00 61.66  ? 489 LEU B O   1 
ATOM   7760  C CB  . LEU B 1 489 ? -8.029  47.877  7.066   1.00 81.04  ? 489 LEU B CB  1 
ATOM   7761  C CG  . LEU B 1 489 ? -6.807  48.746  7.363   1.00 78.91  ? 489 LEU B CG  1 
ATOM   7762  C CD1 . LEU B 1 489 ? -6.331  49.459  6.105   1.00 76.60  ? 489 LEU B CD1 1 
ATOM   7763  C CD2 . LEU B 1 489 ? -7.172  49.727  8.464   1.00 81.29  ? 489 LEU B CD2 1 
ATOM   7764  N N   . ALA B 1 490 ? -10.336 45.864  6.948   1.00 67.08  ? 490 ALA B N   1 
ATOM   7765  C CA  . ALA B 1 490 ? -11.748 45.539  6.829   1.00 71.47  ? 490 ALA B CA  1 
ATOM   7766  C C   . ALA B 1 490 ? -12.189 44.664  8.007   1.00 75.45  ? 490 ALA B C   1 
ATOM   7767  O O   . ALA B 1 490 ? -13.319 44.795  8.491   1.00 61.95  ? 490 ALA B O   1 
ATOM   7768  C CB  . ALA B 1 490 ? -12.015 44.883  5.487   1.00 70.60  ? 490 ALA B CB  1 
ATOM   7769  N N   . ALA B 1 491 ? -11.268 43.799  8.469   1.00 81.28  ? 491 ALA B N   1 
ATOM   7770  C CA  . ALA B 1 491 ? -11.488 42.917  9.605   1.00 78.52  ? 491 ALA B CA  1 
ATOM   7771  C C   . ALA B 1 491 ? -11.804 43.700  10.881  1.00 70.24  ? 491 ALA B C   1 
ATOM   7772  O O   . ALA B 1 491 ? -12.784 43.381  11.537  1.00 70.28  ? 491 ALA B O   1 
ATOM   7773  C CB  . ALA B 1 491 ? -10.281 42.025  9.788   1.00 87.08  ? 491 ALA B CB  1 
ATOM   7774  N N   . ARG B 1 492 ? -10.986 44.710  11.239  1.00 72.76  ? 492 ARG B N   1 
ATOM   7775  C CA  . ARG B 1 492 ? -11.225 45.523  12.431  1.00 65.83  ? 492 ARG B CA  1 
ATOM   7776  C C   . ARG B 1 492 ? -12.584 46.214  12.347  1.00 65.99  ? 492 ARG B C   1 
ATOM   7777  O O   . ARG B 1 492 ? -13.348 46.147  13.302  1.00 65.65  ? 492 ARG B O   1 
ATOM   7778  C CB  . ARG B 1 492 ? -10.162 46.603  12.697  1.00 72.75  ? 492 ARG B CB  1 
ATOM   7779  C CG  . ARG B 1 492 ? -10.464 47.579  13.841  1.00 72.96  ? 492 ARG B CG  1 
ATOM   7780  C CD  . ARG B 1 492 ? -9.407  48.672  14.107  1.00 64.65  ? 492 ARG B CD  1 
ATOM   7781  N NE  . ARG B 1 492 ? -8.066  48.101  14.280  1.00 65.57  ? 492 ARG B NE  1 
ATOM   7782  C CZ  . ARG B 1 492 ? -7.115  47.969  13.341  1.00 72.69  ? 492 ARG B CZ  1 
ATOM   7783  N NH1 . ARG B 1 492 ? -7.103  48.701  12.238  1.00 79.39  ? 492 ARG B NH1 1 
ATOM   7784  N NH2 . ARG B 1 492 ? -6.127  47.112  13.526  1.00 71.50  ? 492 ARG B NH2 1 
ATOM   7785  N N   . ALA B 1 493 ? -12.862 46.892  11.217  1.00 71.98  ? 493 ALA B N   1 
ATOM   7786  C CA  . ALA B 1 493 ? -14.111 47.615  10.994  1.00 67.36  ? 493 ALA B CA  1 
ATOM   7787  C C   . ALA B 1 493 ? -15.319 46.720  11.271  1.00 68.16  ? 493 ALA B C   1 
ATOM   7788  O O   . ALA B 1 493 ? -16.199 47.088  12.053  1.00 56.62  ? 493 ALA B O   1 
ATOM   7789  C CB  . ALA B 1 493 ? -14.166 48.146  9.572   1.00 66.44  ? 493 ALA B CB  1 
ATOM   7790  N N   . ALA B 1 494 ? -15.366 45.554  10.609  1.00 63.83  ? 494 ALA B N   1 
ATOM   7791  C CA  . ALA B 1 494 ? -16.485 44.634  10.772  1.00 67.39  ? 494 ALA B CA  1 
ATOM   7792  C C   . ALA B 1 494 ? -16.652 44.267  12.248  1.00 70.83  ? 494 ALA B C   1 
ATOM   7793  O O   . ALA B 1 494 ? -17.773 44.207  12.746  1.00 70.02  ? 494 ALA B O   1 
ATOM   7794  C CB  . ALA B 1 494 ? -16.305 43.401  9.898   1.00 67.17  ? 494 ALA B CB  1 
ATOM   7795  N N   . GLU B 1 495 ? -15.531 44.074  12.960  1.00 77.68  ? 495 GLU B N   1 
ATOM   7796  C CA  . GLU B 1 495 ? -15.573 43.677  14.361  1.00 76.80  ? 495 GLU B CA  1 
ATOM   7797  C C   . GLU B 1 495 ? -16.034 44.825  15.262  1.00 80.45  ? 495 GLU B C   1 
ATOM   7798  O O   . GLU B 1 495 ? -16.696 44.563  16.261  1.00 86.58  ? 495 GLU B O   1 
ATOM   7799  C CB  . GLU B 1 495 ? -14.238 43.065  14.790  1.00 76.57  ? 495 GLU B CB  1 
ATOM   7800  C CG  . GLU B 1 495 ? -13.856 41.819  13.991  1.00 74.68  ? 495 GLU B CG  1 
ATOM   7801  C CD  . GLU B 1 495 ? -14.823 40.647  14.057  1.00 69.91  ? 495 GLU B CD  1 
ATOM   7802  O OE1 . GLU B 1 495 ? -15.687 40.631  14.966  1.00 68.66  ? 495 GLU B OE1 1 
ATOM   7803  O OE2 . GLU B 1 495 ? -14.724 39.760  13.176  1.00 58.02  ? 495 GLU B OE2 1 
ATOM   7804  N N   . VAL B 1 496 ? -15.708 46.085  14.920  1.00 85.05  ? 496 VAL B N   1 
ATOM   7805  C CA  . VAL B 1 496 ? -16.184 47.239  15.683  1.00 79.41  ? 496 VAL B CA  1 
ATOM   7806  C C   . VAL B 1 496 ? -17.692 47.430  15.461  1.00 74.91  ? 496 VAL B C   1 
ATOM   7807  O O   . VAL B 1 496 ? -18.376 47.930  16.346  1.00 81.75  ? 496 VAL B O   1 
ATOM   7808  C CB  . VAL B 1 496 ? -15.386 48.525  15.368  1.00 80.02  ? 496 VAL B CB  1 
ATOM   7809  C CG1 . VAL B 1 496 ? -16.022 49.784  15.972  1.00 76.82  ? 496 VAL B CG1 1 
ATOM   7810  C CG2 . VAL B 1 496 ? -13.925 48.404  15.796  1.00 71.17  ? 496 VAL B CG2 1 
ATOM   7811  N N   . GLU B 1 497 ? -18.208 47.044  14.280  1.00 77.83  ? 497 GLU B N   1 
ATOM   7812  C CA  . GLU B 1 497 ? -19.642 46.998  14.007  1.00 83.22  ? 497 GLU B CA  1 
ATOM   7813  C C   . GLU B 1 497 ? -20.324 45.911  14.843  1.00 83.84  ? 497 GLU B C   1 
ATOM   7814  O O   . GLU B 1 497 ? -21.376 46.159  15.434  1.00 70.71  ? 497 GLU B O   1 
ATOM   7815  C CB  . GLU B 1 497 ? -19.953 46.681  12.540  1.00 87.98  ? 497 GLU B CB  1 
ATOM   7816  C CG  . GLU B 1 497 ? -20.062 47.894  11.619  1.00 91.95  ? 497 GLU B CG  1 
ATOM   7817  C CD  . GLU B 1 497 ? -20.117 47.527  10.142  1.00 88.29  ? 497 GLU B CD  1 
ATOM   7818  O OE1 . GLU B 1 497 ? -19.061 47.242  9.531   1.00 86.89  ? 497 GLU B OE1 1 
ATOM   7819  O OE2 . GLU B 1 497 ? -21.242 47.494  9.610   1.00 85.82  ? 497 GLU B OE2 1 
ATOM   7820  N N   . LYS B 1 498 ? -19.727 44.707  14.864  1.00 84.44  ? 498 LYS B N   1 
ATOM   7821  C CA  . LYS B 1 498 ? -20.321 43.541  15.509  1.00 95.46  ? 498 LYS B CA  1 
ATOM   7822  C C   . LYS B 1 498 ? -20.318 43.668  17.034  1.00 95.61  ? 498 LYS B C   1 
ATOM   7823  O O   . LYS B 1 498 ? -21.179 43.075  17.677  1.00 91.14  ? 498 LYS B O   1 
ATOM   7824  C CB  . LYS B 1 498 ? -19.649 42.222  15.095  1.00 98.39  ? 498 LYS B CB  1 
ATOM   7825  C CG  . LYS B 1 498 ? -20.222 41.587  13.827  1.00 107.33 ? 498 LYS B CG  1 
ATOM   7826  C CD  . LYS B 1 498 ? -19.268 40.666  13.070  1.00 109.84 ? 498 LYS B CD  1 
ATOM   7827  C CE  . LYS B 1 498 ? -19.722 40.441  11.656  1.00 111.59 ? 498 LYS B CE  1 
ATOM   7828  N NZ  . LYS B 1 498 ? -18.637 39.933  10.816  1.00 110.27 ? 498 LYS B NZ  1 
ATOM   7829  N N   . ASN B 1 499 ? -19.367 44.434  17.601  1.00 99.42  ? 499 ASN B N   1 
ATOM   7830  C CA  . ASN B 1 499 ? -19.215 44.569  19.048  1.00 98.52  ? 499 ASN B CA  1 
ATOM   7831  C C   . ASN B 1 499 ? -19.937 45.823  19.559  1.00 95.23  ? 499 ASN B C   1 
ATOM   7832  O O   . ASN B 1 499 ? -19.575 46.341  20.613  1.00 91.59  ? 499 ASN B O   1 
ATOM   7833  C CB  . ASN B 1 499 ? -17.739 44.551  19.460  1.00 96.28  ? 499 ASN B CB  1 
ATOM   7834  C CG  . ASN B 1 499 ? -17.104 43.174  19.381  1.00 101.24 ? 499 ASN B CG  1 
ATOM   7835  O OD1 . ASN B 1 499 ? -17.419 42.293  20.189  1.00 105.01 ? 499 ASN B OD1 1 
ATOM   7836  N ND2 . ASN B 1 499 ? -16.190 42.959  18.444  1.00 94.86  ? 499 ASN B ND2 1 
ATOM   7837  N N   . SER B 1 500 ? -20.971 46.290  18.835  1.00 92.48  ? 500 SER B N   1 
ATOM   7838  C CA  . SER B 1 500 ? -21.713 47.492  19.194  1.00 93.25  ? 500 SER B CA  1 
ATOM   7839  C C   . SER B 1 500 ? -23.225 47.245  19.060  1.00 84.90  ? 500 SER B C   1 
ATOM   7840  O O   . SER B 1 500 ? -23.980 48.246  19.139  1.00 80.27  ? 500 SER B O   1 
ATOM   7841  C CB  . SER B 1 500 ? -21.275 48.662  18.345  1.00 96.39  ? 500 SER B CB  1 
ATOM   7842  O OG  . SER B 1 500 ? -21.495 48.396  16.966  1.00 101.59 ? 500 SER B OG  1 
ATOM   7843  N N   . MET C 1 1   ? 31.825  53.631  17.356  1.00 74.56  ? 1   MET C N   1 
ATOM   7844  C CA  . MET C 1 1   ? 30.376  53.927  17.219  1.00 78.24  ? 1   MET C CA  1 
ATOM   7845  C C   . MET C 1 1   ? 29.811  54.200  18.615  1.00 77.32  ? 1   MET C C   1 
ATOM   7846  O O   . MET C 1 1   ? 29.988  53.394  19.521  1.00 68.34  ? 1   MET C O   1 
ATOM   7847  C CB  . MET C 1 1   ? 29.627  52.768  16.543  1.00 73.96  ? 1   MET C CB  1 
ATOM   7848  C CG  . MET C 1 1   ? 30.305  52.203  15.302  1.00 71.47  ? 1   MET C CG  1 
ATOM   7849  S SD  . MET C 1 1   ? 29.233  51.230  14.216  1.00 81.63  ? 1   MET C SD  1 
ATOM   7850  C CE  . MET C 1 1   ? 28.216  50.074  15.137  1.00 81.83  ? 1   MET C CE  1 
ATOM   7851  N N   . ARG C 1 2   ? 29.148  55.350  18.785  1.00 73.77  ? 2   ARG C N   1 
ATOM   7852  C CA  . ARG C 1 2   ? 28.601  55.739  20.074  1.00 68.81  ? 2   ARG C CA  1 
ATOM   7853  C C   . ARG C 1 2   ? 27.225  55.112  20.297  1.00 64.86  ? 2   ARG C C   1 
ATOM   7854  O O   . ARG C 1 2   ? 26.478  54.818  19.357  1.00 62.86  ? 2   ARG C O   1 
ATOM   7855  C CB  . ARG C 1 2   ? 28.508  57.263  20.228  1.00 72.52  ? 2   ARG C CB  1 
ATOM   7856  C CG  . ARG C 1 2   ? 29.843  57.932  20.529  1.00 74.26  ? 2   ARG C CG  1 
ATOM   7857  C CD  . ARG C 1 2   ? 29.692  59.395  20.909  1.00 75.35  ? 2   ARG C CD  1 
ATOM   7858  N NE  . ARG C 1 2   ? 29.089  60.179  19.824  1.00 70.75  ? 2   ARG C NE  1 
ATOM   7859  C CZ  . ARG C 1 2   ? 28.524  61.365  19.978  1.00 65.14  ? 2   ARG C CZ  1 
ATOM   7860  N NH1 . ARG C 1 2   ? 28.422  61.888  21.188  1.00 67.73  ? 2   ARG C NH1 1 
ATOM   7861  N NH2 . ARG C 1 2   ? 28.041  62.012  18.931  1.00 64.17  ? 2   ARG C NH2 1 
ATOM   7862  N N   . THR C 1 3   ? 26.912  54.913  21.581  1.00 58.59  ? 3   THR C N   1 
ATOM   7863  C CA  . THR C 1 3   ? 25.590  54.487  21.999  1.00 65.00  ? 3   THR C CA  1 
ATOM   7864  C C   . THR C 1 3   ? 24.683  55.715  22.021  1.00 60.47  ? 3   THR C C   1 
ATOM   7865  O O   . THR C 1 3   ? 25.163  56.838  22.140  1.00 57.93  ? 3   THR C O   1 
ATOM   7866  C CB  . THR C 1 3   ? 25.641  53.838  23.388  1.00 68.58  ? 3   THR C CB  1 
ATOM   7867  O OG1 . THR C 1 3   ? 25.963  54.929  24.250  1.00 66.35  ? 3   THR C OG1 1 
ATOM   7868  C CG2 . THR C 1 3   ? 26.605  52.664  23.498  1.00 58.03  ? 3   THR C CG2 1 
ATOM   7869  N N   . GLY C 1 4   ? 23.371  55.479  21.954  1.00 59.06  ? 4   GLY C N   1 
ATOM   7870  C CA  . GLY C 1 4   ? 22.386  56.473  22.354  1.00 63.28  ? 4   GLY C CA  1 
ATOM   7871  C C   . GLY C 1 4   ? 22.760  57.159  23.671  1.00 61.35  ? 4   GLY C C   1 
ATOM   7872  O O   . GLY C 1 4   ? 22.772  58.388  23.739  1.00 57.04  ? 4   GLY C O   1 
ATOM   7873  N N   . GLN C 1 5   ? 23.079  56.362  24.705  1.00 63.89  ? 5   GLN C N   1 
ATOM   7874  C CA  . GLN C 1 5   ? 23.423  56.907  26.013  1.00 68.29  ? 5   GLN C CA  1 
ATOM   7875  C C   . GLN C 1 5   ? 24.582  57.900  25.915  1.00 60.79  ? 5   GLN C C   1 
ATOM   7876  O O   . GLN C 1 5   ? 24.506  58.996  26.469  1.00 59.82  ? 5   GLN C O   1 
ATOM   7877  C CB  . GLN C 1 5   ? 23.744  55.857  27.082  1.00 72.87  ? 5   GLN C CB  1 
ATOM   7878  C CG  . GLN C 1 5   ? 22.594  55.612  28.050  1.00 82.64  ? 5   GLN C CG  1 
ATOM   7879  C CD  . GLN C 1 5   ? 22.024  56.906  28.599  1.00 94.91  ? 5   GLN C CD  1 
ATOM   7880  O OE1 . GLN C 1 5   ? 22.717  57.661  29.296  1.00 88.71  ? 5   GLN C OE1 1 
ATOM   7881  N NE2 . GLN C 1 5   ? 20.771  57.197  28.259  1.00 84.22  ? 5   GLN C NE2 1 
ATOM   7882  N N   . GLN C 1 6   ? 25.654  57.517  25.219  1.00 62.41  ? 6   GLN C N   1 
ATOM   7883  C CA  . GLN C 1 6   ? 26.817  58.385  25.093  1.00 62.59  ? 6   GLN C CA  1 
ATOM   7884  C C   . GLN C 1 6   ? 26.419  59.633  24.302  1.00 61.24  ? 6   GLN C C   1 
ATOM   7885  O O   . GLN C 1 6   ? 26.876  60.733  24.613  1.00 54.42  ? 6   GLN C O   1 
ATOM   7886  C CB  . GLN C 1 6   ? 28.021  57.667  24.471  1.00 65.90  ? 6   GLN C CB  1 
ATOM   7887  C CG  . GLN C 1 6   ? 28.598  56.527  25.313  1.00 65.40  ? 6   GLN C CG  1 
ATOM   7888  C CD  . GLN C 1 6   ? 29.429  55.545  24.506  1.00 67.16  ? 6   GLN C CD  1 
ATOM   7889  O OE1 . GLN C 1 6   ? 28.950  54.938  23.539  1.00 74.26  ? 6   GLN C OE1 1 
ATOM   7890  N NE2 . GLN C 1 6   ? 30.693  55.380  24.871  1.00 62.18  ? 6   GLN C NE2 1 
ATOM   7891  N N   . TYR C 1 7   ? 25.527  59.459  23.314  1.00 60.49  ? 7   TYR C N   1 
ATOM   7892  C CA  . TYR C 1 7   ? 25.047  60.574  22.512  1.00 60.35  ? 7   TYR C CA  1 
ATOM   7893  C C   . TYR C 1 7   ? 24.262  61.564  23.373  1.00 57.75  ? 7   TYR C C   1 
ATOM   7894  O O   . TYR C 1 7   ? 24.485  62.770  23.262  1.00 56.08  ? 7   TYR C O   1 
ATOM   7895  C CB  . TYR C 1 7   ? 24.173  60.155  21.330  1.00 62.25  ? 7   TYR C CB  1 
ATOM   7896  C CG  . TYR C 1 7   ? 23.395  61.328  20.751  1.00 61.53  ? 7   TYR C CG  1 
ATOM   7897  C CD1 . TYR C 1 7   ? 24.043  62.314  20.015  1.00 59.50  ? 7   TYR C CD1 1 
ATOM   7898  C CD2 . TYR C 1 7   ? 22.024  61.457  20.959  1.00 58.02  ? 7   TYR C CD2 1 
ATOM   7899  C CE1 . TYR C 1 7   ? 23.349  63.392  19.489  1.00 61.95  ? 7   TYR C CE1 1 
ATOM   7900  C CE2 . TYR C 1 7   ? 21.316  62.527  20.434  1.00 59.58  ? 7   TYR C CE2 1 
ATOM   7901  C CZ  . TYR C 1 7   ? 21.980  63.489  19.689  1.00 63.25  ? 7   TYR C CZ  1 
ATOM   7902  O OH  . TYR C 1 7   ? 21.297  64.544  19.163  1.00 59.86  ? 7   TYR C OH  1 
ATOM   7903  N N   . LEU C 1 8   ? 23.333  61.062  24.198  1.00 56.33  ? 8   LEU C N   1 
ATOM   7904  C CA  . LEU C 1 8   ? 22.539  61.932  25.055  1.00 58.52  ? 8   LEU C CA  1 
ATOM   7905  C C   . LEU C 1 8   ? 23.487  62.639  26.026  1.00 59.13  ? 8   LEU C C   1 
ATOM   7906  O O   . LEU C 1 8   ? 23.422  63.859  26.177  1.00 57.00  ? 8   LEU C O   1 
ATOM   7907  C CB  . LEU C 1 8   ? 21.410  61.182  25.775  1.00 57.66  ? 8   LEU C CB  1 
ATOM   7908  C CG  . LEU C 1 8   ? 20.186  60.782  24.933  1.00 64.16  ? 8   LEU C CG  1 
ATOM   7909  C CD1 . LEU C 1 8   ? 19.224  59.830  25.654  1.00 64.73  ? 8   LEU C CD1 1 
ATOM   7910  C CD2 . LEU C 1 8   ? 19.384  61.997  24.471  1.00 63.10  ? 8   LEU C CD2 1 
ATOM   7911  N N   . GLU C 1 9   ? 24.411  61.878  26.626  1.00 58.25  ? 9   GLU C N   1 
ATOM   7912  C CA  . GLU C 1 9   ? 25.341  62.426  27.606  1.00 65.77  ? 9   GLU C CA  1 
ATOM   7913  C C   . GLU C 1 9   ? 26.154  63.572  26.997  1.00 56.68  ? 9   GLU C C   1 
ATOM   7914  O O   . GLU C 1 9   ? 26.371  64.582  27.657  1.00 61.64  ? 9   GLU C O   1 
ATOM   7915  C CB  . GLU C 1 9   ? 26.258  61.351  28.212  1.00 74.17  ? 9   GLU C CB  1 
ATOM   7916  C CG  . GLU C 1 9   ? 26.949  61.753  29.519  1.00 77.89  ? 9   GLU C CG  1 
ATOM   7917  C CD  . GLU C 1 9   ? 26.023  62.291  30.608  1.00 86.98  ? 9   GLU C CD  1 
ATOM   7918  O OE1 . GLU C 1 9   ? 24.921  61.733  30.809  1.00 84.73  ? 9   GLU C OE1 1 
ATOM   7919  O OE2 . GLU C 1 9   ? 26.394  63.288  31.259  1.00 84.00  ? 9   GLU C OE2 1 
ATOM   7920  N N   . SER C 1 10  ? 26.591  63.437  25.740  1.00 56.17  ? 10  SER C N   1 
ATOM   7921  C CA  . SER C 1 10  ? 27.425  64.453  25.107  1.00 59.66  ? 10  SER C CA  1 
ATOM   7922  C C   . SER C 1 10  ? 26.679  65.787  24.941  1.00 58.85  ? 10  SER C C   1 
ATOM   7923  O O   . SER C 1 10  ? 27.320  66.830  24.771  1.00 50.35  ? 10  SER C O   1 
ATOM   7924  C CB  . SER C 1 10  ? 27.971  63.966  23.779  1.00 63.25  ? 10  SER C CB  1 
ATOM   7925  O OG  . SER C 1 10  ? 26.924  63.700  22.845  1.00 59.25  ? 10  SER C OG  1 
ATOM   7926  N N   . LEU C 1 11  ? 25.332  65.756  25.003  1.00 60.08  ? 11  LEU C N   1 
ATOM   7927  C CA  . LEU C 1 11  ? 24.515  66.958  24.868  1.00 61.31  ? 11  LEU C CA  1 
ATOM   7928  C C   . LEU C 1 11  ? 24.420  67.749  26.181  1.00 59.29  ? 11  LEU C C   1 
ATOM   7929  O O   . LEU C 1 11  ? 24.003  68.904  26.150  1.00 60.32  ? 11  LEU C O   1 
ATOM   7930  C CB  . LEU C 1 11  ? 23.127  66.601  24.328  1.00 63.23  ? 11  LEU C CB  1 
ATOM   7931  C CG  . LEU C 1 11  ? 23.072  65.888  22.965  1.00 60.52  ? 11  LEU C CG  1 
ATOM   7932  C CD1 . LEU C 1 11  ? 21.628  65.814  22.503  1.00 58.06  ? 11  LEU C CD1 1 
ATOM   7933  C CD2 . LEU C 1 11  ? 23.931  66.494  21.864  1.00 60.21  ? 11  LEU C CD2 1 
ATOM   7934  N N   . ARG C 1 12  ? 24.800  67.151  27.324  1.00 58.57  ? 12  ARG C N   1 
ATOM   7935  C CA  . ARG C 1 12  ? 24.753  67.826  28.616  1.00 61.94  ? 12  ARG C CA  1 
ATOM   7936  C C   . ARG C 1 12  ? 26.114  68.437  28.945  1.00 62.90  ? 12  ARG C C   1 
ATOM   7937  O O   . ARG C 1 12  ? 26.818  67.966  29.832  1.00 65.58  ? 12  ARG C O   1 
ATOM   7938  C CB  . ARG C 1 12  ? 24.328  66.834  29.701  1.00 66.84  ? 12  ARG C CB  1 
ATOM   7939  C CG  . ARG C 1 12  ? 22.879  66.407  29.539  1.00 73.74  ? 12  ARG C CG  1 
ATOM   7940  C CD  . ARG C 1 12  ? 22.614  64.959  29.908  1.00 82.17  ? 12  ARG C CD  1 
ATOM   7941  N NE  . ARG C 1 12  ? 22.165  64.777  31.291  1.00 95.44  ? 12  ARG C NE  1 
ATOM   7942  C CZ  . ARG C 1 12  ? 21.617  63.650  31.739  1.00 106.47 ? 12  ARG C CZ  1 
ATOM   7943  N NH1 . ARG C 1 12  ? 21.466  62.618  30.923  1.00 108.54 ? 12  ARG C NH1 1 
ATOM   7944  N NH2 . ARG C 1 12  ? 21.215  63.554  32.994  1.00 96.12  ? 12  ARG C NH2 1 
ATOM   7945  N N   . ASP C 1 13  ? 26.432  69.534  28.258  1.00 62.74  ? 13  ASP C N   1 
ATOM   7946  C CA  . ASP C 1 13  ? 27.777  70.071  28.180  1.00 63.54  ? 13  ASP C CA  1 
ATOM   7947  C C   . ASP C 1 13  ? 27.779  71.594  28.381  1.00 62.69  ? 13  ASP C C   1 
ATOM   7948  O O   . ASP C 1 13  ? 28.732  72.264  27.954  1.00 60.18  ? 13  ASP C O   1 
ATOM   7949  C CB  . ASP C 1 13  ? 28.396  69.687  26.840  1.00 67.36  ? 13  ASP C CB  1 
ATOM   7950  C CG  . ASP C 1 13  ? 27.666  70.203  25.603  1.00 64.09  ? 13  ASP C CG  1 
ATOM   7951  O OD1 . ASP C 1 13  ? 26.509  70.673  25.739  1.00 58.44  ? 13  ASP C OD1 1 
ATOM   7952  O OD2 . ASP C 1 13  ? 28.272  70.171  24.516  1.00 56.30  ? 13  ASP C OD2 1 
ATOM   7953  N N   . GLY C 1 14  ? 26.719  72.137  29.012  1.00 55.96  ? 14  GLY C N   1 
ATOM   7954  C CA  . GLY C 1 14  ? 26.615  73.566  29.294  1.00 58.54  ? 14  GLY C CA  1 
ATOM   7955  C C   . GLY C 1 14  ? 26.461  74.458  28.051  1.00 63.67  ? 14  GLY C C   1 
ATOM   7956  O O   . GLY C 1 14  ? 26.698  75.663  28.127  1.00 64.81  ? 14  GLY C O   1 
ATOM   7957  N N   . ARG C 1 15  ? 26.062  73.879  26.908  1.00 63.25  ? 15  ARG C N   1 
ATOM   7958  C CA  . ARG C 1 15  ? 25.699  74.632  25.713  1.00 57.93  ? 15  ARG C CA  1 
ATOM   7959  C C   . ARG C 1 15  ? 24.625  75.663  26.056  1.00 51.74  ? 15  ARG C C   1 
ATOM   7960  O O   . ARG C 1 15  ? 23.756  75.367  26.874  1.00 56.54  ? 15  ARG C O   1 
ATOM   7961  C CB  . ARG C 1 15  ? 25.173  73.660  24.644  1.00 54.48  ? 15  ARG C CB  1 
ATOM   7962  C CG  . ARG C 1 15  ? 23.876  72.952  25.025  1.00 59.90  ? 15  ARG C CG  1 
ATOM   7963  C CD  . ARG C 1 15  ? 23.453  71.869  24.034  1.00 60.17  ? 15  ARG C CD  1 
ATOM   7964  N NE  . ARG C 1 15  ? 24.591  70.983  23.777  1.00 61.74  ? 15  ARG C NE  1 
ATOM   7965  C CZ  . ARG C 1 15  ? 24.917  70.455  22.613  1.00 61.35  ? 15  ARG C CZ  1 
ATOM   7966  N NH1 . ARG C 1 15  ? 24.048  70.444  21.612  1.00 62.45  ? 15  ARG C NH1 1 
ATOM   7967  N NH2 . ARG C 1 15  ? 26.102  69.896  22.479  1.00 57.02  ? 15  ARG C NH2 1 
ATOM   7968  N N   . GLN C 1 16  ? 24.701  76.849  25.419  1.00 51.20  ? 16  GLN C N   1 
ATOM   7969  C CA  . GLN C 1 16  ? 23.735  77.930  25.572  1.00 52.91  ? 16  GLN C CA  1 
ATOM   7970  C C   . GLN C 1 16  ? 22.712  77.865  24.432  1.00 52.26  ? 16  GLN C C   1 
ATOM   7971  O O   . GLN C 1 16  ? 23.012  78.267  23.311  1.00 54.26  ? 16  GLN C O   1 
ATOM   7972  C CB  . GLN C 1 16  ? 24.423  79.298  25.591  1.00 60.63  ? 16  GLN C CB  1 
ATOM   7973  C CG  . GLN C 1 16  ? 25.244  79.588  26.847  1.00 75.63  ? 16  GLN C CG  1 
ATOM   7974  C CD  . GLN C 1 16  ? 24.451  79.617  28.145  1.00 84.49  ? 16  GLN C CD  1 
ATOM   7975  O OE1 . GLN C 1 16  ? 23.798  80.609  28.497  1.00 80.04  ? 16  GLN C OE1 1 
ATOM   7976  N NE2 . GLN C 1 16  ? 24.547  78.538  28.909  1.00 89.34  ? 16  GLN C NE2 1 
ATOM   7977  N N   . VAL C 1 17  ? 21.489  77.401  24.739  1.00 48.71  ? 17  VAL C N   1 
ATOM   7978  C CA  . VAL C 1 17  ? 20.500  77.054  23.729  1.00 49.31  ? 17  VAL C CA  1 
ATOM   7979  C C   . VAL C 1 17  ? 19.188  77.763  24.032  1.00 51.64  ? 17  VAL C C   1 
ATOM   7980  O O   . VAL C 1 17  ? 18.600  77.574  25.103  1.00 49.12  ? 17  VAL C O   1 
ATOM   7981  C CB  . VAL C 1 17  ? 20.265  75.543  23.581  1.00 51.50  ? 17  VAL C CB  1 
ATOM   7982  C CG1 . VAL C 1 17  ? 18.969  75.230  22.841  1.00 53.03  ? 17  VAL C CG1 1 
ATOM   7983  C CG2 . VAL C 1 17  ? 21.441  74.873  22.889  1.00 52.36  ? 17  VAL C CG2 1 
ATOM   7984  N N   . TYR C 1 18  ? 18.763  78.569  23.050  1.00 52.01  ? 18  TYR C N   1 
ATOM   7985  C CA  . TYR C 1 18  ? 17.523  79.321  23.107  1.00 59.39  ? 18  TYR C CA  1 
ATOM   7986  C C   . TYR C 1 18  ? 16.539  78.669  22.138  1.00 59.43  ? 18  TYR C C   1 
ATOM   7987  O O   . TYR C 1 18  ? 16.886  78.397  20.981  1.00 53.32  ? 18  TYR C O   1 
ATOM   7988  C CB  . TYR C 1 18  ? 17.779  80.803  22.797  1.00 60.50  ? 18  TYR C CB  1 
ATOM   7989  C CG  . TYR C 1 18  ? 18.622  81.549  23.833  1.00 61.16  ? 18  TYR C CG  1 
ATOM   7990  C CD1 . TYR C 1 18  ? 20.011  81.604  23.728  1.00 63.57  ? 18  TYR C CD1 1 
ATOM   7991  C CD2 . TYR C 1 18  ? 18.031  82.196  24.920  1.00 55.68  ? 18  TYR C CD2 1 
ATOM   7992  C CE1 . TYR C 1 18  ? 20.789  82.271  24.667  1.00 55.32  ? 18  TYR C CE1 1 
ATOM   7993  C CE2 . TYR C 1 18  ? 18.795  82.871  25.859  1.00 53.56  ? 18  TYR C CE2 1 
ATOM   7994  C CZ  . TYR C 1 18  ? 20.177  82.905  25.732  1.00 54.67  ? 18  TYR C CZ  1 
ATOM   7995  O OH  . TYR C 1 18  ? 20.946  83.566  26.641  1.00 60.57  ? 18  TYR C OH  1 
ATOM   7996  N N   . VAL C 1 19  ? 15.321  78.427  22.644  1.00 52.95  ? 19  VAL C N   1 
ATOM   7997  C CA  . VAL C 1 19  ? 14.236  77.841  21.878  1.00 54.51  ? 19  VAL C CA  1 
ATOM   7998  C C   . VAL C 1 19  ? 12.970  78.651  22.146  1.00 50.01  ? 19  VAL C C   1 
ATOM   7999  O O   . VAL C 1 19  ? 12.427  78.589  23.246  1.00 45.95  ? 19  VAL C O   1 
ATOM   8000  C CB  . VAL C 1 19  ? 14.014  76.351  22.220  1.00 51.12  ? 19  VAL C CB  1 
ATOM   8001  C CG1 . VAL C 1 19  ? 12.831  75.792  21.449  1.00 49.84  ? 19  VAL C CG1 1 
ATOM   8002  C CG2 . VAL C 1 19  ? 15.257  75.499  21.963  1.00 48.65  ? 19  VAL C CG2 1 
ATOM   8003  N N   . GLY C 1 20  ? 12.523  79.411  21.136  1.00 53.63  ? 20  GLY C N   1 
ATOM   8004  C CA  . GLY C 1 20  ? 11.399  80.329  21.273  1.00 55.43  ? 20  GLY C CA  1 
ATOM   8005  C C   . GLY C 1 20  ? 11.688  81.504  22.210  1.00 49.94  ? 20  GLY C C   1 
ATOM   8006  O O   . GLY C 1 20  ? 10.766  82.226  22.592  1.00 49.16  ? 20  GLY C O   1 
ATOM   8007  N N   . GLY C 1 21  ? 12.968  81.710  22.548  1.00 53.95  ? 21  GLY C N   1 
ATOM   8008  C CA  . GLY C 1 21  ? 13.388  82.725  23.510  1.00 61.34  ? 21  GLY C CA  1 
ATOM   8009  C C   . GLY C 1 21  ? 13.730  82.164  24.897  1.00 57.74  ? 21  GLY C C   1 
ATOM   8010  O O   . GLY C 1 21  ? 14.267  82.885  25.735  1.00 53.67  ? 21  GLY C O   1 
ATOM   8011  N N   . GLU C 1 22  ? 13.417  80.888  25.149  1.00 52.12  ? 22  GLU C N   1 
ATOM   8012  C CA  . GLU C 1 22  ? 13.652  80.287  26.454  1.00 57.42  ? 22  GLU C CA  1 
ATOM   8013  C C   . GLU C 1 22  ? 15.018  79.613  26.491  1.00 56.59  ? 22  GLU C C   1 
ATOM   8014  O O   . GLU C 1 22  ? 15.300  78.745  25.664  1.00 56.67  ? 22  GLU C O   1 
ATOM   8015  C CB  . GLU C 1 22  ? 12.593  79.217  26.714  1.00 62.57  ? 22  GLU C CB  1 
ATOM   8016  C CG  . GLU C 1 22  ? 12.794  78.463  28.024  1.00 63.64  ? 22  GLU C CG  1 
ATOM   8017  C CD  . GLU C 1 22  ? 11.748  77.398  28.306  1.00 59.19  ? 22  GLU C CD  1 
ATOM   8018  O OE1 . GLU C 1 22  ? 10.763  77.219  27.549  1.00 58.91  ? 22  GLU C OE1 1 
ATOM   8019  O OE2 . GLU C 1 22  ? 11.960  76.731  29.329  1.00 61.30  ? 22  GLU C OE2 1 
ATOM   8020  N N   . LEU C 1 23  ? 15.852  80.003  27.460  1.00 58.94  ? 23  LEU C N   1 
ATOM   8021  C CA  . LEU C 1 23  ? 17.124  79.333  27.682  1.00 59.54  ? 23  LEU C CA  1 
ATOM   8022  C C   . LEU C 1 23  ? 16.862  77.910  28.180  1.00 58.45  ? 23  LEU C C   1 
ATOM   8023  O O   . LEU C 1 23  ? 16.119  77.725  29.133  1.00 61.54  ? 23  LEU C O   1 
ATOM   8024  C CB  . LEU C 1 23  ? 17.972  80.112  28.682  1.00 64.84  ? 23  LEU C CB  1 
ATOM   8025  C CG  . LEU C 1 23  ? 19.400  79.585  28.886  1.00 72.25  ? 23  LEU C CG  1 
ATOM   8026  C CD1 . LEU C 1 23  ? 20.206  79.633  27.602  1.00 67.46  ? 23  LEU C CD1 1 
ATOM   8027  C CD2 . LEU C 1 23  ? 20.138  80.356  29.980  1.00 78.17  ? 23  LEU C CD2 1 
ATOM   8028  N N   . ILE C 1 24  ? 17.458  76.904  27.524  1.00 58.94  ? 24  ILE C N   1 
ATOM   8029  C CA  . ILE C 1 24  ? 17.205  75.503  27.851  1.00 55.96  ? 24  ILE C CA  1 
ATOM   8030  C C   . ILE C 1 24  ? 18.336  74.976  28.728  1.00 60.10  ? 24  ILE C C   1 
ATOM   8031  O O   . ILE C 1 24  ? 19.451  74.791  28.239  1.00 59.19  ? 24  ILE C O   1 
ATOM   8032  C CB  . ILE C 1 24  ? 17.085  74.643  26.580  1.00 54.89  ? 24  ILE C CB  1 
ATOM   8033  C CG1 . ILE C 1 24  ? 16.111  75.251  25.562  1.00 57.52  ? 24  ILE C CG1 1 
ATOM   8034  C CG2 . ILE C 1 24  ? 16.718  73.201  26.936  1.00 53.76  ? 24  ILE C CG2 1 
ATOM   8035  C CD1 . ILE C 1 24  ? 14.683  75.384  26.062  1.00 63.81  ? 24  ILE C CD1 1 
ATOM   8036  N N   . ASP C 1 25  ? 18.020  74.724  30.004  1.00 64.29  ? 25  ASP C N   1 
ATOM   8037  C CA  . ASP C 1 25  ? 18.925  74.109  30.968  1.00 66.00  ? 25  ASP C CA  1 
ATOM   8038  C C   . ASP C 1 25  ? 19.584  72.856  30.391  1.00 61.31  ? 25  ASP C C   1 
ATOM   8039  O O   . ASP C 1 25  ? 20.803  72.733  30.433  1.00 64.96  ? 25  ASP C O   1 
ATOM   8040  C CB  . ASP C 1 25  ? 18.192  73.754  32.258  1.00 76.03  ? 25  ASP C CB  1 
ATOM   8041  C CG  . ASP C 1 25  ? 16.853  73.019  32.124  1.00 84.46  ? 25  ASP C CG  1 
ATOM   8042  O OD1 . ASP C 1 25  ? 16.478  72.629  30.991  1.00 77.99  ? 25  ASP C OD1 1 
ATOM   8043  O OD2 . ASP C 1 25  ? 16.166  72.851  33.159  1.00 86.53  ? 25  ASP C OD2 1 
ATOM   8044  N N   . ASP C 1 26  ? 18.761  71.941  29.863  1.00 55.44  ? 26  ASP C N   1 
ATOM   8045  C CA  . ASP C 1 26  ? 19.174  70.583  29.519  1.00 59.21  ? 26  ASP C CA  1 
ATOM   8046  C C   . ASP C 1 26  ? 18.322  70.092  28.347  1.00 54.14  ? 26  ASP C C   1 
ATOM   8047  O O   . ASP C 1 26  ? 17.130  69.814  28.495  1.00 47.56  ? 26  ASP C O   1 
ATOM   8048  C CB  . ASP C 1 26  ? 19.058  69.626  30.702  1.00 61.34  ? 26  ASP C CB  1 
ATOM   8049  C CG  . ASP C 1 26  ? 19.624  68.222  30.491  1.00 67.07  ? 26  ASP C CG  1 
ATOM   8050  O OD1 . ASP C 1 26  ? 19.398  67.636  29.410  1.00 60.93  ? 26  ASP C OD1 1 
ATOM   8051  O OD2 . ASP C 1 26  ? 20.281  67.704  31.415  1.00 75.73  ? 26  ASP C OD2 1 
ATOM   8052  N N   . VAL C 1 27  ? 18.955  69.984  27.175  1.00 54.75  ? 27  VAL C N   1 
ATOM   8053  C CA  . VAL C 1 27  ? 18.276  69.645  25.933  1.00 54.19  ? 27  VAL C CA  1 
ATOM   8054  C C   . VAL C 1 27  ? 17.676  68.235  25.971  1.00 60.10  ? 27  VAL C C   1 
ATOM   8055  O O   . VAL C 1 27  ? 16.671  67.994  25.298  1.00 63.22  ? 27  VAL C O   1 
ATOM   8056  C CB  . VAL C 1 27  ? 19.347  69.834  24.846  1.00 55.66  ? 27  VAL C CB  1 
ATOM   8057  C CG1 . VAL C 1 27  ? 19.279  68.807  23.726  1.00 61.12  ? 27  VAL C CG1 1 
ATOM   8058  C CG2 . VAL C 1 27  ? 19.307  71.255  24.309  1.00 58.52  ? 27  VAL C CG2 1 
ATOM   8059  N N   . THR C 1 28  ? 18.263  67.323  26.775  1.00 55.16  ? 28  THR C N   1 
ATOM   8060  C CA  . THR C 1 28  ? 17.839  65.926  26.825  1.00 58.54  ? 28  THR C CA  1 
ATOM   8061  C C   . THR C 1 28  ? 16.579  65.753  27.675  1.00 58.89  ? 28  THR C C   1 
ATOM   8062  O O   . THR C 1 28  ? 15.914  64.730  27.532  1.00 58.32  ? 28  THR C O   1 
ATOM   8063  C CB  . THR C 1 28  ? 18.940  64.999  27.358  1.00 58.24  ? 28  THR C CB  1 
ATOM   8064  O OG1 . THR C 1 28  ? 19.115  65.276  28.744  1.00 57.46  ? 28  THR C OG1 1 
ATOM   8065  C CG2 . THR C 1 28  ? 20.278  65.150  26.651  1.00 57.79  ? 28  THR C CG2 1 
ATOM   8066  N N   . THR C 1 29  ? 16.265  66.701  28.577  1.00 58.92  ? 29  THR C N   1 
ATOM   8067  C CA  . THR C 1 29  ? 15.143  66.513  29.498  1.00 63.99  ? 29  THR C CA  1 
ATOM   8068  C C   . THR C 1 29  ? 14.028  67.532  29.244  1.00 63.70  ? 29  THR C C   1 
ATOM   8069  O O   . THR C 1 29  ? 12.882  67.264  29.606  1.00 57.75  ? 29  THR C O   1 
ATOM   8070  C CB  . THR C 1 29  ? 15.587  66.537  30.969  1.00 66.12  ? 29  THR C CB  1 
ATOM   8071  O OG1 . THR C 1 29  ? 16.098  67.828  31.288  1.00 55.38  ? 29  THR C OG1 1 
ATOM   8072  C CG2 . THR C 1 29  ? 16.614  65.464  31.299  1.00 64.73  ? 29  THR C CG2 1 
ATOM   8073  N N   . HIS C 1 30  ? 14.348  68.682  28.624  1.00 57.75  ? 30  HIS C N   1 
ATOM   8074  C CA  . HIS C 1 30  ? 13.357  69.729  28.420  1.00 58.03  ? 30  HIS C CA  1 
ATOM   8075  C C   . HIS C 1 30  ? 12.243  69.247  27.480  1.00 57.52  ? 30  HIS C C   1 
ATOM   8076  O O   . HIS C 1 30  ? 12.483  68.672  26.422  1.00 59.59  ? 30  HIS C O   1 
ATOM   8077  C CB  . HIS C 1 30  ? 14.014  71.035  27.951  1.00 54.82  ? 30  HIS C CB  1 
ATOM   8078  C CG  . HIS C 1 30  ? 13.121  72.229  28.082  1.00 57.31  ? 30  HIS C CG  1 
ATOM   8079  N ND1 . HIS C 1 30  ? 11.952  72.372  27.358  1.00 56.58  ? 30  HIS C ND1 1 
ATOM   8080  C CD2 . HIS C 1 30  ? 13.207  73.319  28.865  1.00 57.10  ? 30  HIS C CD2 1 
ATOM   8081  C CE1 . HIS C 1 30  ? 11.360  73.519  27.694  1.00 51.76  ? 30  HIS C CE1 1 
ATOM   8082  N NE2 . HIS C 1 30  ? 12.108  74.113  28.602  1.00 54.38  ? 30  HIS C NE2 1 
ATOM   8083  N N   . PRO C 1 31  ? 10.958  69.461  27.821  1.00 56.51  ? 31  PRO C N   1 
ATOM   8084  C CA  . PRO C 1 31  ? 9.874   69.035  26.940  1.00 53.17  ? 31  PRO C CA  1 
ATOM   8085  C C   . PRO C 1 31  ? 9.987   69.523  25.497  1.00 52.89  ? 31  PRO C C   1 
ATOM   8086  O O   . PRO C 1 31  ? 9.473   68.868  24.600  1.00 55.81  ? 31  PRO C O   1 
ATOM   8087  C CB  . PRO C 1 31  ? 8.602   69.592  27.615  1.00 55.07  ? 31  PRO C CB  1 
ATOM   8088  C CG  . PRO C 1 31  ? 8.995   69.834  29.054  1.00 56.79  ? 31  PRO C CG  1 
ATOM   8089  C CD  . PRO C 1 31  ? 10.490  70.098  29.062  1.00 56.37  ? 31  PRO C CD  1 
ATOM   8090  N N   . LYS C 1 32  ? 10.596  70.696  25.269  1.00 53.88  ? 32  LYS C N   1 
ATOM   8091  C CA  . LYS C 1 32  ? 10.621  71.282  23.934  1.00 53.66  ? 32  LYS C CA  1 
ATOM   8092  C C   . LYS C 1 32  ? 11.558  70.506  23.004  1.00 50.08  ? 32  LYS C C   1 
ATOM   8093  O O   . LYS C 1 32  ? 11.356  70.521  21.790  1.00 43.22  ? 32  LYS C O   1 
ATOM   8094  C CB  . LYS C 1 32  ? 11.027  72.767  23.927  1.00 54.24  ? 32  LYS C CB  1 
ATOM   8095  C CG  . LYS C 1 32  ? 9.947   73.763  24.367  1.00 53.49  ? 32  LYS C CG  1 
ATOM   8096  C CD  . LYS C 1 32  ? 10.427  75.192  24.633  1.00 54.61  ? 32  LYS C CD  1 
ATOM   8097  C CE  . LYS C 1 32  ? 9.279   76.110  24.953  1.00 53.74  ? 32  LYS C CE  1 
ATOM   8098  N NZ  . LYS C 1 32  ? 9.569   77.500  24.629  1.00 54.02  ? 32  LYS C NZ  1 
ATOM   8099  N N   . THR C 1 33  ? 12.590  69.869  23.582  1.00 48.77  ? 33  THR C N   1 
ATOM   8100  C CA  . THR C 1 33  ? 13.728  69.357  22.823  1.00 52.33  ? 33  THR C CA  1 
ATOM   8101  C C   . THR C 1 33  ? 13.899  67.848  23.008  1.00 50.74  ? 33  THR C C   1 
ATOM   8102  O O   . THR C 1 33  ? 14.570  67.220  22.196  1.00 50.21  ? 33  THR C O   1 
ATOM   8103  C CB  . THR C 1 33  ? 15.013  70.091  23.230  1.00 53.98  ? 33  THR C CB  1 
ATOM   8104  O OG1 . THR C 1 33  ? 15.066  70.085  24.659  1.00 47.34  ? 33  THR C OG1 1 
ATOM   8105  C CG2 . THR C 1 33  ? 15.068  71.509  22.683  1.00 52.20  ? 33  THR C CG2 1 
ATOM   8106  N N   . SER C 1 34  ? 13.279  67.273  24.047  1.00 55.61  ? 34  SER C N   1 
ATOM   8107  C CA  . SER C 1 34  ? 13.662  65.958  24.539  1.00 56.37  ? 34  SER C CA  1 
ATOM   8108  C C   . SER C 1 34  ? 13.310  64.877  23.522  1.00 49.48  ? 34  SER C C   1 
ATOM   8109  O O   . SER C 1 34  ? 14.113  63.988  23.306  1.00 48.45  ? 34  SER C O   1 
ATOM   8110  C CB  . SER C 1 34  ? 13.062  65.649  25.912  1.00 55.27  ? 34  SER C CB  1 
ATOM   8111  O OG  . SER C 1 34  ? 11.646  65.541  25.854  1.00 58.90  ? 34  SER C OG  1 
ATOM   8112  N N   . GLY C 1 35  ? 12.112  64.951  22.924  1.00 50.71  ? 35  GLY C N   1 
ATOM   8113  C CA  . GLY C 1 35  ? 11.647  63.960  21.959  1.00 47.57  ? 35  GLY C CA  1 
ATOM   8114  C C   . GLY C 1 35  ? 12.637  63.737  20.809  1.00 53.80  ? 35  GLY C C   1 
ATOM   8115  O O   . GLY C 1 35  ? 13.000  62.594  20.505  1.00 58.95  ? 35  GLY C O   1 
ATOM   8116  N N   . TYR C 1 36  ? 13.095  64.830  20.180  1.00 51.22  ? 36  TYR C N   1 
ATOM   8117  C CA  . TYR C 1 36  ? 14.000  64.726  19.045  1.00 49.74  ? 36  TYR C CA  1 
ATOM   8118  C C   . TYR C 1 36  ? 15.365  64.227  19.511  1.00 51.15  ? 36  TYR C C   1 
ATOM   8119  O O   . TYR C 1 36  ? 16.008  63.489  18.770  1.00 51.37  ? 36  TYR C O   1 
ATOM   8120  C CB  . TYR C 1 36  ? 14.175  66.035  18.271  1.00 45.74  ? 36  TYR C CB  1 
ATOM   8121  C CG  . TYR C 1 36  ? 15.099  65.917  17.063  1.00 46.39  ? 36  TYR C CG  1 
ATOM   8122  C CD1 . TYR C 1 36  ? 14.657  65.404  15.846  1.00 49.66  ? 36  TYR C CD1 1 
ATOM   8123  C CD2 . TYR C 1 36  ? 16.427  66.310  17.143  1.00 45.28  ? 36  TYR C CD2 1 
ATOM   8124  C CE1 . TYR C 1 36  ? 15.503  65.304  14.753  1.00 48.47  ? 36  TYR C CE1 1 
ATOM   8125  C CE2 . TYR C 1 36  ? 17.278  66.236  16.052  1.00 48.83  ? 36  TYR C CE2 1 
ATOM   8126  C CZ  . TYR C 1 36  ? 16.813  65.742  14.848  1.00 50.90  ? 36  TYR C CZ  1 
ATOM   8127  O OH  . TYR C 1 36  ? 17.682  65.660  13.790  1.00 55.65  ? 36  TYR C OH  1 
ATOM   8128  N N   . ALA C 1 37  ? 15.801  64.656  20.710  1.00 58.30  ? 37  ALA C N   1 
ATOM   8129  C CA  . ALA C 1 37  ? 17.014  64.154  21.349  1.00 57.29  ? 37  ALA C CA  1 
ATOM   8130  C C   . ALA C 1 37  ? 16.977  62.628  21.424  1.00 60.13  ? 37  ALA C C   1 
ATOM   8131  O O   . ALA C 1 37  ? 17.946  61.972  21.024  1.00 54.74  ? 37  ALA C O   1 
ATOM   8132  C CB  . ALA C 1 37  ? 17.191  64.753  22.725  1.00 53.67  ? 37  ALA C CB  1 
ATOM   8133  N N   . LYS C 1 38  ? 15.836  62.092  21.891  1.00 56.66  ? 38  LYS C N   1 
ATOM   8134  C CA  . LYS C 1 38  ? 15.656  60.658  22.055  1.00 68.00  ? 38  LYS C CA  1 
ATOM   8135  C C   . LYS C 1 38  ? 15.636  59.968  20.678  1.00 65.03  ? 38  LYS C C   1 
ATOM   8136  O O   . LYS C 1 38  ? 16.160  58.869  20.531  1.00 62.15  ? 38  LYS C O   1 
ATOM   8137  C CB  . LYS C 1 38  ? 14.476  60.388  23.008  1.00 69.79  ? 38  LYS C CB  1 
ATOM   8138  C CG  . LYS C 1 38  ? 14.175  58.901  23.281  1.00 87.33  ? 38  LYS C CG  1 
ATOM   8139  C CD  . LYS C 1 38  ? 15.336  58.097  23.872  1.00 105.63 ? 38  LYS C CD  1 
ATOM   8140  C CE  . LYS C 1 38  ? 15.369  56.631  23.509  1.00 110.11 ? 38  LYS C CE  1 
ATOM   8141  N NZ  . LYS C 1 38  ? 16.656  56.014  23.856  1.00 103.53 ? 38  LYS C NZ  1 
ATOM   8142  N N   . ALA C 1 39  ? 15.100  60.612  19.637  1.00 62.20  ? 39  ALA C N   1 
ATOM   8143  C CA  . ALA C 1 39  ? 15.052  59.975  18.327  1.00 63.36  ? 39  ALA C CA  1 
ATOM   8144  C C   . ALA C 1 39  ? 16.455  59.807  17.723  1.00 62.16  ? 39  ALA C C   1 
ATOM   8145  O O   . ALA C 1 39  ? 16.746  58.792  17.088  1.00 64.70  ? 39  ALA C O   1 
ATOM   8146  C CB  . ALA C 1 39  ? 14.132  60.738  17.398  1.00 58.45  ? 39  ALA C CB  1 
ATOM   8147  N N   . ILE C 1 40  ? 17.337  60.795  17.909  1.00 63.31  ? 40  ILE C N   1 
ATOM   8148  C CA  . ILE C 1 40  ? 18.697  60.678  17.397  1.00 63.21  ? 40  ILE C CA  1 
ATOM   8149  C C   . ILE C 1 40  ? 19.450  59.635  18.233  1.00 58.15  ? 40  ILE C C   1 
ATOM   8150  O O   . ILE C 1 40  ? 20.296  58.925  17.706  1.00 52.06  ? 40  ILE C O   1 
ATOM   8151  C CB  . ILE C 1 40  ? 19.420  62.046  17.328  1.00 64.22  ? 40  ILE C CB  1 
ATOM   8152  C CG1 . ILE C 1 40  ? 18.591  63.109  16.580  1.00 61.75  ? 40  ILE C CG1 1 
ATOM   8153  C CG2 . ILE C 1 40  ? 20.806  61.911  16.688  1.00 63.27  ? 40  ILE C CG2 1 
ATOM   8154  C CD1 . ILE C 1 40  ? 18.206  62.695  15.167  1.00 59.67  ? 40  ILE C CD1 1 
ATOM   8155  N N   . ALA C 1 41  ? 19.110  59.515  19.523  1.00 55.76  ? 41  ALA C N   1 
ATOM   8156  C CA  . ALA C 1 41  ? 19.752  58.556  20.406  1.00 55.23  ? 41  ALA C CA  1 
ATOM   8157  C C   . ALA C 1 41  ? 19.441  57.118  19.959  1.00 61.93  ? 41  ALA C C   1 
ATOM   8158  O O   . ALA C 1 41  ? 20.341  56.289  19.849  1.00 58.14  ? 41  ALA C O   1 
ATOM   8159  C CB  . ALA C 1 41  ? 19.311  58.819  21.823  1.00 47.00  ? 41  ALA C CB  1 
ATOM   8160  N N   . GLU C 1 42  ? 18.157  56.841  19.708  1.00 59.75  ? 42  GLU C N   1 
ATOM   8161  C CA  . GLU C 1 42  ? 17.684  55.616  19.081  1.00 62.17  ? 42  GLU C CA  1 
ATOM   8162  C C   . GLU C 1 42  ? 18.387  55.375  17.740  1.00 60.74  ? 42  GLU C C   1 
ATOM   8163  O O   . GLU C 1 42  ? 18.716  54.239  17.430  1.00 66.40  ? 42  GLU C O   1 
ATOM   8164  C CB  . GLU C 1 42  ? 16.167  55.794  18.996  1.00 70.65  ? 42  GLU C CB  1 
ATOM   8165  C CG  . GLU C 1 42  ? 15.394  54.708  18.252  1.00 81.85  ? 42  GLU C CG  1 
ATOM   8166  C CD  . GLU C 1 42  ? 13.909  55.032  18.097  1.00 91.97  ? 42  GLU C CD  1 
ATOM   8167  O OE1 . GLU C 1 42  ? 13.428  56.015  18.729  1.00 87.00  ? 42  GLU C OE1 1 
ATOM   8168  O OE2 . GLU C 1 42  ? 13.230  54.305  17.328  1.00 79.63  ? 42  GLU C OE2 1 
ATOM   8169  N N   . TYR C 1 43  ? 18.609  56.433  16.947  1.00 58.53  ? 43  TYR C N   1 
ATOM   8170  C CA  . TYR C 1 43  ? 19.308  56.347  15.670  1.00 60.51  ? 43  TYR C CA  1 
ATOM   8171  C C   . TYR C 1 43  ? 20.684  55.717  15.871  1.00 61.06  ? 43  TYR C C   1 
ATOM   8172  O O   . TYR C 1 43  ? 21.093  54.856  15.081  1.00 61.76  ? 43  TYR C O   1 
ATOM   8173  C CB  . TYR C 1 43  ? 19.409  57.740  15.018  1.00 55.56  ? 43  TYR C CB  1 
ATOM   8174  C CG  . TYR C 1 43  ? 20.430  57.958  13.900  1.00 45.57  ? 43  TYR C CG  1 
ATOM   8175  C CD1 . TYR C 1 43  ? 21.769  58.207  14.188  1.00 52.33  ? 43  TYR C CD1 1 
ATOM   8176  C CD2 . TYR C 1 43  ? 20.055  57.972  12.559  1.00 48.20  ? 43  TYR C CD2 1 
ATOM   8177  C CE1 . TYR C 1 43  ? 22.703  58.428  13.183  1.00 52.01  ? 43  TYR C CE1 1 
ATOM   8178  C CE2 . TYR C 1 43  ? 20.976  58.179  11.540  1.00 47.98  ? 43  TYR C CE2 1 
ATOM   8179  C CZ  . TYR C 1 43  ? 22.307  58.411  11.856  1.00 50.85  ? 43  TYR C CZ  1 
ATOM   8180  O OH  . TYR C 1 43  ? 23.244  58.635  10.895  1.00 48.14  ? 43  TYR C OH  1 
ATOM   8181  N N   . TYR C 1 44  ? 21.390  56.181  16.914  1.00 59.52  ? 44  TYR C N   1 
ATOM   8182  C CA  . TYR C 1 44  ? 22.737  55.714  17.213  1.00 59.83  ? 44  TYR C CA  1 
ATOM   8183  C C   . TYR C 1 44  ? 22.683  54.243  17.633  1.00 63.69  ? 44  TYR C C   1 
ATOM   8184  O O   . TYR C 1 44  ? 23.522  53.455  17.186  1.00 66.14  ? 44  TYR C O   1 
ATOM   8185  C CB  . TYR C 1 44  ? 23.442  56.576  18.264  1.00 56.39  ? 44  TYR C CB  1 
ATOM   8186  C CG  . TYR C 1 44  ? 24.143  57.820  17.729  1.00 60.03  ? 44  TYR C CG  1 
ATOM   8187  C CD1 . TYR C 1 44  ? 25.457  57.751  17.269  1.00 61.28  ? 44  TYR C CD1 1 
ATOM   8188  C CD2 . TYR C 1 44  ? 23.510  59.064  17.701  1.00 55.02  ? 44  TYR C CD2 1 
ATOM   8189  C CE1 . TYR C 1 44  ? 26.116  58.874  16.791  1.00 63.68  ? 44  TYR C CE1 1 
ATOM   8190  C CE2 . TYR C 1 44  ? 24.157  60.195  17.221  1.00 55.02  ? 44  TYR C CE2 1 
ATOM   8191  C CZ  . TYR C 1 44  ? 25.468  60.102  16.775  1.00 62.90  ? 44  TYR C CZ  1 
ATOM   8192  O OH  . TYR C 1 44  ? 26.133  61.194  16.286  1.00 59.08  ? 44  TYR C OH  1 
ATOM   8193  N N   . ASP C 1 45  ? 21.680  53.875  18.448  1.00 52.71  ? 45  ASP C N   1 
ATOM   8194  C CA  . ASP C 1 45  ? 21.555  52.516  18.954  1.00 58.69  ? 45  ASP C CA  1 
ATOM   8195  C C   . ASP C 1 45  ? 21.355  51.519  17.812  1.00 61.54  ? 45  ASP C C   1 
ATOM   8196  O O   . ASP C 1 45  ? 21.991  50.471  17.811  1.00 61.37  ? 45  ASP C O   1 
ATOM   8197  C CB  . ASP C 1 45  ? 20.475  52.412  20.016  1.00 52.99  ? 45  ASP C CB  1 
ATOM   8198  C CG  . ASP C 1 45  ? 20.873  52.931  21.386  1.00 53.87  ? 45  ASP C CG  1 
ATOM   8199  O OD1 . ASP C 1 45  ? 22.090  53.068  21.646  1.00 63.69  ? 45  ASP C OD1 1 
ATOM   8200  O OD2 . ASP C 1 45  ? 19.961  53.201  22.177  1.00 56.48  ? 45  ASP C OD2 1 
ATOM   8201  N N   . LEU C 1 46  ? 20.507  51.867  16.836  1.00 60.37  ? 46  LEU C N   1 
ATOM   8202  C CA  . LEU C 1 46  ? 20.195  50.976  15.729  1.00 64.62  ? 46  LEU C CA  1 
ATOM   8203  C C   . LEU C 1 46  ? 21.469  50.635  14.955  1.00 66.36  ? 46  LEU C C   1 
ATOM   8204  O O   . LEU C 1 46  ? 21.641  49.498  14.528  1.00 67.10  ? 46  LEU C O   1 
ATOM   8205  C CB  . LEU C 1 46  ? 19.133  51.580  14.809  1.00 63.64  ? 46  LEU C CB  1 
ATOM   8206  C CG  . LEU C 1 46  ? 17.707  51.641  15.368  1.00 64.37  ? 46  LEU C CG  1 
ATOM   8207  C CD1 . LEU C 1 46  ? 16.849  52.492  14.452  1.00 65.75  ? 46  LEU C CD1 1 
ATOM   8208  C CD2 . LEU C 1 46  ? 17.077  50.259  15.567  1.00 63.14  ? 46  LEU C CD2 1 
ATOM   8209  N N   . HIS C 1 47  ? 22.373  51.605  14.786  1.00 68.18  ? 47  HIS C N   1 
ATOM   8210  C CA  . HIS C 1 47  ? 23.659  51.324  14.155  1.00 70.37  ? 47  HIS C CA  1 
ATOM   8211  C C   . HIS C 1 47  ? 24.383  50.178  14.865  1.00 70.39  ? 47  HIS C C   1 
ATOM   8212  O O   . HIS C 1 47  ? 25.053  49.378  14.212  1.00 66.65  ? 47  HIS C O   1 
ATOM   8213  C CB  . HIS C 1 47  ? 24.542  52.575  14.106  1.00 67.62  ? 47  HIS C CB  1 
ATOM   8214  C CG  . HIS C 1 47  ? 24.141  53.533  13.046  1.00 66.84  ? 47  HIS C CG  1 
ATOM   8215  N ND1 . HIS C 1 47  ? 23.038  54.355  13.151  1.00 70.21  ? 47  HIS C ND1 1 
ATOM   8216  C CD2 . HIS C 1 47  ? 24.679  53.773  11.849  1.00 65.37  ? 47  HIS C CD2 1 
ATOM   8217  C CE1 . HIS C 1 47  ? 22.942  55.088  12.050  1.00 64.57  ? 47  HIS C CE1 1 
ATOM   8218  N NE2 . HIS C 1 47  ? 23.931  54.751  11.246  1.00 65.19  ? 47  HIS C NE2 1 
ATOM   8219  N N   . LEU C 1 48  ? 24.231  50.114  16.197  1.00 64.61  ? 48  LEU C N   1 
ATOM   8220  C CA  . LEU C 1 48  ? 24.874  49.102  17.017  1.00 68.06  ? 48  LEU C CA  1 
ATOM   8221  C C   . LEU C 1 48  ? 24.105  47.780  16.978  1.00 68.02  ? 48  LEU C C   1 
ATOM   8222  O O   . LEU C 1 48  ? 24.630  46.761  17.414  1.00 63.81  ? 48  LEU C O   1 
ATOM   8223  C CB  . LEU C 1 48  ? 25.033  49.632  18.445  1.00 65.99  ? 48  LEU C CB  1 
ATOM   8224  C CG  . LEU C 1 48  ? 26.123  50.693  18.649  1.00 67.66  ? 48  LEU C CG  1 
ATOM   8225  C CD1 . LEU C 1 48  ? 26.125  51.194  20.081  1.00 68.72  ? 48  LEU C CD1 1 
ATOM   8226  C CD2 . LEU C 1 48  ? 27.512  50.196  18.292  1.00 63.09  ? 48  LEU C CD2 1 
ATOM   8227  N N   . ASP C 1 49  ? 22.875  47.788  16.453  1.00 71.82  ? 49  ASP C N   1 
ATOM   8228  C CA  . ASP C 1 49  ? 22.080  46.573  16.393  1.00 82.46  ? 49  ASP C CA  1 
ATOM   8229  C C   . ASP C 1 49  ? 22.600  45.672  15.275  1.00 95.31  ? 49  ASP C C   1 
ATOM   8230  O O   . ASP C 1 49  ? 22.588  46.061  14.107  1.00 90.23  ? 49  ASP C O   1 
ATOM   8231  C CB  . ASP C 1 49  ? 20.602  46.850  16.189  1.00 79.97  ? 49  ASP C CB  1 
ATOM   8232  C CG  . ASP C 1 49  ? 19.682  45.671  16.470  1.00 87.60  ? 49  ASP C CG  1 
ATOM   8233  O OD1 . ASP C 1 49  ? 18.673  45.885  17.174  1.00 82.24  ? 49  ASP C OD1 1 
ATOM   8234  O OD2 . ASP C 1 49  ? 19.988  44.544  15.999  1.00 89.77  ? 49  ASP C OD2 1 
ATOM   8235  N N   . PRO C 1 50  ? 23.065  44.442  15.605  1.00 108.81 ? 50  PRO C N   1 
ATOM   8236  C CA  . PRO C 1 50  ? 23.491  43.465  14.593  1.00 107.67 ? 50  PRO C CA  1 
ATOM   8237  C C   . PRO C 1 50  ? 22.520  43.146  13.453  1.00 90.07  ? 50  PRO C C   1 
ATOM   8238  O O   . PRO C 1 50  ? 22.952  42.829  12.349  1.00 80.48  ? 50  PRO C O   1 
ATOM   8239  C CB  . PRO C 1 50  ? 23.758  42.227  15.467  1.00 111.80 ? 50  PRO C CB  1 
ATOM   8240  C CG  . PRO C 1 50  ? 24.229  42.809  16.778  1.00 110.52 ? 50  PRO C CG  1 
ATOM   8241  C CD  . PRO C 1 50  ? 23.265  43.956  16.983  1.00 105.72 ? 50  PRO C CD  1 
ATOM   8242  N N   . GLU C 1 51  ? 21.212  43.235  13.714  1.00 85.02  ? 51  GLU C N   1 
ATOM   8243  C CA  . GLU C 1 51  ? 20.214  42.985  12.684  1.00 88.24  ? 51  GLU C CA  1 
ATOM   8244  C C   . GLU C 1 51  ? 20.365  43.961  11.509  1.00 87.44  ? 51  GLU C C   1 
ATOM   8245  O O   . GLU C 1 51  ? 20.053  43.614  10.372  1.00 77.01  ? 51  GLU C O   1 
ATOM   8246  C CB  . GLU C 1 51  ? 18.813  43.059  13.290  1.00 93.47  ? 51  GLU C CB  1 
ATOM   8247  C CG  . GLU C 1 51  ? 17.740  42.483  12.368  1.00 106.67 ? 51  GLU C CG  1 
ATOM   8248  C CD  . GLU C 1 51  ? 16.433  42.128  13.057  1.00 111.12 ? 51  GLU C CD  1 
ATOM   8249  O OE1 . GLU C 1 51  ? 16.455  41.390  14.074  1.00 100.93 ? 51  GLU C OE1 1 
ATOM   8250  O OE2 . GLU C 1 51  ? 15.384  42.588  12.555  1.00 110.75 ? 51  GLU C OE2 1 
ATOM   8251  N N   . HIS C 1 52  ? 20.852  45.183  11.771  1.00 85.10  ? 52  HIS C N   1 
ATOM   8252  C CA  . HIS C 1 52  ? 20.918  46.214  10.742  1.00 77.32  ? 52  HIS C CA  1 
ATOM   8253  C C   . HIS C 1 52  ? 22.366  46.480  10.325  1.00 76.57  ? 52  HIS C C   1 
ATOM   8254  O O   . HIS C 1 52  ? 22.631  47.447  9.609   1.00 73.95  ? 52  HIS C O   1 
ATOM   8255  C CB  . HIS C 1 52  ? 20.170  47.473  11.207  1.00 71.04  ? 52  HIS C CB  1 
ATOM   8256  C CG  . HIS C 1 52  ? 18.779  47.219  11.712  1.00 69.85  ? 52  HIS C CG  1 
ATOM   8257  N ND1 . HIS C 1 52  ? 18.444  47.292  13.051  1.00 68.62  ? 52  HIS C ND1 1 
ATOM   8258  C CD2 . HIS C 1 52  ? 17.636  46.914  11.056  1.00 63.56  ? 52  HIS C CD2 1 
ATOM   8259  C CE1 . HIS C 1 52  ? 17.146  47.036  13.200  1.00 63.57  ? 52  HIS C CE1 1 
ATOM   8260  N NE2 . HIS C 1 52  ? 16.637  46.808  12.001  1.00 65.95  ? 52  HIS C NE2 1 
ATOM   8261  N N   . GLN C 1 53  ? 23.286  45.587  10.717  1.00 72.14  ? 53  GLN C N   1 
ATOM   8262  C CA  . GLN C 1 53  ? 24.705  45.740  10.431  1.00 74.80  ? 53  GLN C CA  1 
ATOM   8263  C C   . GLN C 1 53  ? 24.988  45.849  8.929   1.00 74.63  ? 53  GLN C C   1 
ATOM   8264  O O   . GLN C 1 53  ? 25.885  46.592  8.529   1.00 70.90  ? 53  GLN C O   1 
ATOM   8265  C CB  . GLN C 1 53  ? 25.512  44.583  11.020  1.00 76.14  ? 53  GLN C CB  1 
ATOM   8266  C CG  . GLN C 1 53  ? 27.019  44.746  10.843  1.00 84.65  ? 53  GLN C CG  1 
ATOM   8267  C CD  . GLN C 1 53  ? 27.825  43.587  11.386  1.00 87.44  ? 53  GLN C CD  1 
ATOM   8268  O OE1 . GLN C 1 53  ? 28.007  43.447  12.601  1.00 77.04  ? 53  GLN C OE1 1 
ATOM   8269  N NE2 . GLN C 1 53  ? 28.343  42.760  10.485  1.00 80.75  ? 53  GLN C NE2 1 
ATOM   8270  N N   . ASP C 1 54  ? 24.254  45.105  8.090   1.00 76.59  ? 54  ASP C N   1 
ATOM   8271  C CA  . ASP C 1 54  ? 24.549  45.079  6.662   1.00 77.14  ? 54  ASP C CA  1 
ATOM   8272  C C   . ASP C 1 54  ? 24.327  46.453  6.028   1.00 73.29  ? 54  ASP C C   1 
ATOM   8273  O O   . ASP C 1 54  ? 25.217  46.976  5.361   1.00 68.00  ? 54  ASP C O   1 
ATOM   8274  C CB  . ASP C 1 54  ? 23.806  43.965  5.941   1.00 82.59  ? 54  ASP C CB  1 
ATOM   8275  C CG  . ASP C 1 54  ? 24.418  42.577  6.097   1.00 93.50  ? 54  ASP C CG  1 
ATOM   8276  O OD1 . ASP C 1 54  ? 25.215  42.385  7.046   1.00 96.52  ? 54  ASP C OD1 1 
ATOM   8277  O OD2 . ASP C 1 54  ? 24.127  41.706  5.248   1.00 86.56  ? 54  ASP C OD2 1 
ATOM   8278  N N   . VAL C 1 55  ? 23.153  47.055  6.253   1.00 75.23  ? 55  VAL C N   1 
ATOM   8279  C CA  . VAL C 1 55  ? 22.821  48.315  5.599   1.00 73.71  ? 55  VAL C CA  1 
ATOM   8280  C C   . VAL C 1 55  ? 23.427  49.516  6.355   1.00 71.26  ? 55  VAL C C   1 
ATOM   8281  O O   . VAL C 1 55  ? 23.707  50.522  5.707   1.00 58.55  ? 55  VAL C O   1 
ATOM   8282  C CB  . VAL C 1 55  ? 21.297  48.444  5.345   1.00 75.78  ? 55  VAL C CB  1 
ATOM   8283  C CG1 . VAL C 1 55  ? 20.470  48.431  6.634   1.00 73.78  ? 55  VAL C CG1 1 
ATOM   8284  C CG2 . VAL C 1 55  ? 20.940  49.656  4.477   1.00 74.31  ? 55  VAL C CG2 1 
ATOM   8285  N N   . LEU C 1 56  ? 23.698  49.413  7.681   1.00 69.60  ? 56  LEU C N   1 
ATOM   8286  C CA  . LEU C 1 56  ? 23.977  50.588  8.513   1.00 66.09  ? 56  LEU C CA  1 
ATOM   8287  C C   . LEU C 1 56  ? 25.469  50.810  8.754   1.00 67.95  ? 56  LEU C C   1 
ATOM   8288  O O   . LEU C 1 56  ? 25.852  51.936  9.076   1.00 65.77  ? 56  LEU C O   1 
ATOM   8289  C CB  . LEU C 1 56  ? 23.278  50.578  9.876   1.00 64.36  ? 56  LEU C CB  1 
ATOM   8290  C CG  . LEU C 1 56  ? 21.745  50.614  9.874   1.00 62.80  ? 56  LEU C CG  1 
ATOM   8291  C CD1 . LEU C 1 56  ? 21.231  50.805  11.293  1.00 65.13  ? 56  LEU C CD1 1 
ATOM   8292  C CD2 . LEU C 1 56  ? 21.166  51.674  8.942   1.00 61.22  ? 56  LEU C CD2 1 
ATOM   8293  N N   . THR C 1 57  ? 26.294  49.757  8.664   1.00 69.52  ? 57  THR C N   1 
ATOM   8294  C CA  . THR C 1 57  ? 27.691  49.862  9.082   1.00 72.25  ? 57  THR C CA  1 
ATOM   8295  C C   . THR C 1 57  ? 28.610  49.383  7.960   1.00 68.87  ? 57  THR C C   1 
ATOM   8296  O O   . THR C 1 57  ? 28.146  48.806  6.981   1.00 65.18  ? 57  THR C O   1 
ATOM   8297  C CB  . THR C 1 57  ? 27.930  49.086  10.383  1.00 73.86  ? 57  THR C CB  1 
ATOM   8298  O OG1 . THR C 1 57  ? 27.762  47.686  10.140  1.00 69.64  ? 57  THR C OG1 1 
ATOM   8299  C CG2 . THR C 1 57  ? 27.005  49.535  11.503  1.00 69.24  ? 57  THR C CG2 1 
ATOM   8300  N N   . PHE C 1 58  ? 29.909  49.671  8.117   1.00 73.09  ? 58  PHE C N   1 
ATOM   8301  C CA  . PHE C 1 58  ? 30.954  49.171  7.234   1.00 79.64  ? 58  PHE C CA  1 
ATOM   8302  C C   . PHE C 1 58  ? 32.270  49.093  8.007   1.00 82.40  ? 58  PHE C C   1 
ATOM   8303  O O   . PHE C 1 58  ? 32.402  49.692  9.074   1.00 73.80  ? 58  PHE C O   1 
ATOM   8304  C CB  . PHE C 1 58  ? 31.174  50.050  5.997   1.00 75.52  ? 58  PHE C CB  1 
ATOM   8305  C CG  . PHE C 1 58  ? 31.931  51.349  6.255   1.00 73.98  ? 58  PHE C CG  1 
ATOM   8306  C CD1 . PHE C 1 58  ? 31.365  52.370  7.026   1.00 67.49  ? 58  PHE C CD1 1 
ATOM   8307  C CD2 . PHE C 1 58  ? 33.198  51.560  5.708   1.00 73.36  ? 58  PHE C CD2 1 
ATOM   8308  C CE1 . PHE C 1 58  ? 32.053  53.555  7.259   1.00 65.67  ? 58  PHE C CE1 1 
ATOM   8309  C CE2 . PHE C 1 58  ? 33.881  52.754  5.930   1.00 71.25  ? 58  PHE C CE2 1 
ATOM   8310  C CZ  . PHE C 1 58  ? 33.310  53.747  6.711   1.00 73.12  ? 58  PHE C CZ  1 
ATOM   8311  N N   . VAL C 1 59  ? 33.245  48.378  7.423   1.00 82.39  ? 59  VAL C N   1 
ATOM   8312  C CA  . VAL C 1 59  ? 34.582  48.257  7.981   1.00 78.89  ? 59  VAL C CA  1 
ATOM   8313  C C   . VAL C 1 59  ? 35.552  49.123  7.172   1.00 72.06  ? 59  VAL C C   1 
ATOM   8314  O O   . VAL C 1 59  ? 35.659  48.976  5.956   1.00 74.37  ? 59  VAL C O   1 
ATOM   8315  C CB  . VAL C 1 59  ? 35.008  46.777  8.006   1.00 80.53  ? 59  VAL C CB  1 
ATOM   8316  C CG1 . VAL C 1 59  ? 36.375  46.609  8.659   1.00 83.24  ? 59  VAL C CG1 1 
ATOM   8317  C CG2 . VAL C 1 59  ? 33.974  45.896  8.702   1.00 79.99  ? 59  VAL C CG2 1 
ATOM   8318  N N   . ASP C 1 60  ? 36.270  50.018  7.859   1.00 66.26  ? 60  ASP C N   1 
ATOM   8319  C CA  . ASP C 1 60  ? 37.074  51.053  7.216   1.00 75.67  ? 60  ASP C CA  1 
ATOM   8320  C C   . ASP C 1 60  ? 38.431  50.465  6.815   1.00 87.08  ? 60  ASP C C   1 
ATOM   8321  O O   . ASP C 1 60  ? 38.722  49.299  7.093   1.00 70.55  ? 60  ASP C O   1 
ATOM   8322  C CB  . ASP C 1 60  ? 37.186  52.275  8.126   1.00 79.37  ? 60  ASP C CB  1 
ATOM   8323  C CG  . ASP C 1 60  ? 37.370  53.647  7.474   1.00 93.94  ? 60  ASP C CG  1 
ATOM   8324  O OD1 . ASP C 1 60  ? 37.766  53.703  6.282   1.00 91.78  ? 60  ASP C OD1 1 
ATOM   8325  O OD2 . ASP C 1 60  ? 37.101  54.671  8.163   1.00 84.24  ? 60  ASP C OD2 1 
ATOM   8326  N N   . ASP C 1 61  ? 39.248  51.290  6.138   1.00 111.42 ? 61  ASP C N   1 
ATOM   8327  C CA  . ASP C 1 61  ? 40.647  50.995  5.839   1.00 112.16 ? 61  ASP C CA  1 
ATOM   8328  C C   . ASP C 1 61  ? 41.318  50.346  7.054   1.00 115.01 ? 61  ASP C C   1 
ATOM   8329  O O   . ASP C 1 61  ? 41.744  49.190  6.982   1.00 103.50 ? 61  ASP C O   1 
ATOM   8330  C CB  . ASP C 1 61  ? 41.374  52.260  5.395   1.00 110.09 ? 61  ASP C CB  1 
ATOM   8331  C CG  . ASP C 1 61  ? 41.115  52.744  3.970   1.00 104.24 ? 61  ASP C CG  1 
ATOM   8332  O OD1 . ASP C 1 61  ? 41.781  52.236  3.045   1.00 94.91  ? 61  ASP C OD1 1 
ATOM   8333  O OD2 . ASP C 1 61  ? 40.260  53.639  3.785   1.00 87.74  ? 61  ASP C OD2 1 
ATOM   8334  N N   . ASP C 1 62  ? 41.334  51.093  8.174   1.00 115.34 ? 62  ASP C N   1 
ATOM   8335  C CA  . ASP C 1 62  ? 42.018  50.740  9.416   1.00 109.39 ? 62  ASP C CA  1 
ATOM   8336  C C   . ASP C 1 62  ? 41.453  49.477  10.085  1.00 107.07 ? 62  ASP C C   1 
ATOM   8337  O O   . ASP C 1 62  ? 42.047  48.958  11.029  1.00 102.20 ? 62  ASP C O   1 
ATOM   8338  C CB  . ASP C 1 62  ? 42.023  51.931  10.368  1.00 109.03 ? 62  ASP C CB  1 
ATOM   8339  C CG  . ASP C 1 62  ? 40.663  52.475  10.798  1.00 111.16 ? 62  ASP C CG  1 
ATOM   8340  O OD1 . ASP C 1 62  ? 39.661  51.727  10.708  1.00 113.08 ? 62  ASP C OD1 1 
ATOM   8341  O OD2 . ASP C 1 62  ? 40.608  53.655  11.213  1.00 98.02  ? 62  ASP C OD2 1 
ATOM   8342  N N   . GLY C 1 63  ? 40.292  48.988  9.638   1.00 103.95 ? 63  GLY C N   1 
ATOM   8343  C CA  . GLY C 1 63  ? 39.741  47.749  10.164  1.00 98.83  ? 63  GLY C CA  1 
ATOM   8344  C C   . GLY C 1 63  ? 38.672  47.982  11.236  1.00 99.21  ? 63  GLY C C   1 
ATOM   8345  O O   . GLY C 1 63  ? 38.075  47.018  11.714  1.00 82.31  ? 63  GLY C O   1 
ATOM   8346  N N   . VAL C 1 64  ? 38.423  49.252  11.604  1.00 100.22 ? 64  VAL C N   1 
ATOM   8347  C CA  . VAL C 1 64  ? 37.417  49.587  12.609  1.00 98.22  ? 64  VAL C CA  1 
ATOM   8348  C C   . VAL C 1 64  ? 36.031  49.584  11.946  1.00 85.89  ? 64  VAL C C   1 
ATOM   8349  O O   . VAL C 1 64  ? 35.881  50.089  10.833  1.00 81.34  ? 64  VAL C O   1 
ATOM   8350  C CB  . VAL C 1 64  ? 37.739  50.942  13.286  1.00 92.99  ? 64  VAL C CB  1 
ATOM   8351  C CG1 . VAL C 1 64  ? 36.653  51.376  14.268  1.00 84.57  ? 64  VAL C CG1 1 
ATOM   8352  C CG2 . VAL C 1 64  ? 39.102  50.936  13.980  1.00 85.20  ? 64  VAL C CG2 1 
ATOM   8353  N N   . ARG C 1 65  ? 35.028  48.996  12.624  1.00 77.40  ? 65  ARG C N   1 
ATOM   8354  C CA  . ARG C 1 65  ? 33.644  49.035  12.159  1.00 76.89  ? 65  ARG C CA  1 
ATOM   8355  C C   . ARG C 1 65  ? 33.033  50.384  12.541  1.00 74.49  ? 65  ARG C C   1 
ATOM   8356  O O   . ARG C 1 65  ? 32.975  50.721  13.723  1.00 72.04  ? 65  ARG C O   1 
ATOM   8357  C CB  . ARG C 1 65  ? 32.741  47.914  12.693  1.00 75.87  ? 65  ARG C CB  1 
ATOM   8358  C CG  . ARG C 1 65  ? 31.309  47.986  12.171  1.00 81.59  ? 65  ARG C CG  1 
ATOM   8359  C CD  . ARG C 1 65  ? 30.375  46.888  12.688  1.00 79.10  ? 65  ARG C CD  1 
ATOM   8360  N NE  . ARG C 1 65  ? 30.801  45.549  12.265  1.00 82.80  ? 65  ARG C NE  1 
ATOM   8361  C CZ  . ARG C 1 65  ? 30.864  45.126  11.008  1.00 89.60  ? 65  ARG C CZ  1 
ATOM   8362  N NH1 . ARG C 1 65  ? 30.322  45.834  10.036  1.00 91.64  ? 65  ARG C NH1 1 
ATOM   8363  N NH2 . ARG C 1 65  ? 31.448  43.977  10.721  1.00 91.99  ? 65  ARG C NH2 1 
ATOM   8364  N N   . LYS C 1 66  ? 32.600  51.142  11.515  1.00 72.89  ? 66  LYS C N   1 
ATOM   8365  C CA  . LYS C 1 66  ? 32.055  52.480  11.675  1.00 67.98  ? 66  LYS C CA  1 
ATOM   8366  C C   . LYS C 1 66  ? 30.705  52.588  10.963  1.00 68.73  ? 66  LYS C C   1 
ATOM   8367  O O   . LYS C 1 66  ? 30.392  51.802  10.066  1.00 68.10  ? 66  LYS C O   1 
ATOM   8368  C CB  . LYS C 1 66  ? 33.024  53.522  11.112  1.00 71.81  ? 66  LYS C CB  1 
ATOM   8369  C CG  . LYS C 1 66  ? 34.349  53.653  11.839  1.00 77.31  ? 66  LYS C CG  1 
ATOM   8370  C CD  . LYS C 1 66  ? 35.437  54.333  11.015  1.00 84.83  ? 66  LYS C CD  1 
ATOM   8371  C CE  . LYS C 1 66  ? 36.706  54.481  11.804  1.00 95.82  ? 66  LYS C CE  1 
ATOM   8372  N NZ  . LYS C 1 66  ? 37.886  54.799  10.995  1.00 94.78  ? 66  LYS C NZ  1 
ATOM   8373  N N   . SER C 1 67  ? 29.924  53.598  11.368  1.00 65.67  ? 67  SER C N   1 
ATOM   8374  C CA  . SER C 1 67  ? 28.622  53.880  10.788  1.00 64.87  ? 67  SER C CA  1 
ATOM   8375  C C   . SER C 1 67  ? 28.762  54.435  9.365   1.00 62.11  ? 67  SER C C   1 
ATOM   8376  O O   . SER C 1 67  ? 29.702  55.176  9.071   1.00 56.20  ? 67  SER C O   1 
ATOM   8377  C CB  . SER C 1 67  ? 27.859  54.826  11.678  1.00 66.63  ? 67  SER C CB  1 
ATOM   8378  O OG  . SER C 1 67  ? 27.616  54.247  12.954  1.00 69.51  ? 67  SER C OG  1 
ATOM   8379  N N   . MET C 1 68  ? 27.791  54.081  8.502   1.00 53.05  ? 68  MET C N   1 
ATOM   8380  C CA  . MET C 1 68  ? 27.763  54.480  7.099   1.00 54.65  ? 68  MET C CA  1 
ATOM   8381  C C   . MET C 1 68  ? 27.652  56.000  6.930   1.00 52.27  ? 68  MET C C   1 
ATOM   8382  O O   . MET C 1 68  ? 27.973  56.519  5.860   1.00 52.45  ? 68  MET C O   1 
ATOM   8383  C CB  . MET C 1 68  ? 26.623  53.779  6.336   1.00 54.55  ? 68  MET C CB  1 
ATOM   8384  C CG  . MET C 1 68  ? 26.923  52.310  5.991   1.00 64.50  ? 68  MET C CG  1 
ATOM   8385  S SD  . MET C 1 68  ? 28.132  52.071  4.664   1.00 63.92  ? 68  MET C SD  1 
ATOM   8386  C CE  . MET C 1 68  ? 27.009  52.505  3.323   1.00 67.52  ? 68  MET C CE  1 
ATOM   8387  N N   . HIS C 1 69  ? 27.248  56.737  7.974   1.00 56.90  ? 69  HIS C N   1 
ATOM   8388  C CA  . HIS C 1 69  ? 27.270  58.189  7.871   1.00 62.36  ? 69  HIS C CA  1 
ATOM   8389  C C   . HIS C 1 69  ? 28.711  58.677  7.694   1.00 61.04  ? 69  HIS C C   1 
ATOM   8390  O O   . HIS C 1 69  ? 28.914  59.848  7.370   1.00 66.11  ? 69  HIS C O   1 
ATOM   8391  C CB  . HIS C 1 69  ? 26.442  58.860  8.979   1.00 64.16  ? 69  HIS C CB  1 
ATOM   8392  C CG  . HIS C 1 69  ? 26.859  58.561  10.379  1.00 73.58  ? 69  HIS C CG  1 
ATOM   8393  N ND1 . HIS C 1 69  ? 25.941  58.456  11.405  1.00 74.24  ? 69  HIS C ND1 1 
ATOM   8394  C CD2 . HIS C 1 69  ? 28.066  58.364  10.939  1.00 74.02  ? 69  HIS C CD2 1 
ATOM   8395  C CE1 . HIS C 1 69  ? 26.579  58.203  12.542  1.00 74.37  ? 69  HIS C CE1 1 
ATOM   8396  N NE2 . HIS C 1 69  ? 27.873  58.144  12.283  1.00 77.29  ? 69  HIS C NE2 1 
ATOM   8397  N N   . TRP C 1 70  ? 29.705  57.786  7.881   1.00 58.00  ? 70  TRP C N   1 
ATOM   8398  C CA  . TRP C 1 70  ? 31.098  58.124  7.609   1.00 58.31  ? 70  TRP C CA  1 
ATOM   8399  C C   . TRP C 1 70  ? 31.640  57.467  6.328   1.00 59.98  ? 70  TRP C C   1 
ATOM   8400  O O   . TRP C 1 70  ? 32.828  57.611  6.046   1.00 52.88  ? 70  TRP C O   1 
ATOM   8401  C CB  . TRP C 1 70  ? 31.971  57.730  8.805   1.00 61.18  ? 70  TRP C CB  1 
ATOM   8402  C CG  . TRP C 1 70  ? 31.639  58.404  10.110  1.00 54.55  ? 70  TRP C CG  1 
ATOM   8403  C CD1 . TRP C 1 70  ? 31.384  57.776  11.293  1.00 53.71  ? 70  TRP C CD1 1 
ATOM   8404  C CD2 . TRP C 1 70  ? 31.594  59.821  10.389  1.00 53.04  ? 70  TRP C CD2 1 
ATOM   8405  N NE1 . TRP C 1 70  ? 31.153  58.692  12.285  1.00 53.29  ? 70  TRP C NE1 1 
ATOM   8406  C CE2 . TRP C 1 70  ? 31.281  59.954  11.761  1.00 53.30  ? 70  TRP C CE2 1 
ATOM   8407  C CE3 . TRP C 1 70  ? 31.765  60.980  9.623   1.00 56.16  ? 70  TRP C CE3 1 
ATOM   8408  C CZ2 . TRP C 1 70  ? 31.135  61.199  12.367  1.00 53.32  ? 70  TRP C CZ2 1 
ATOM   8409  C CZ3 . TRP C 1 70  ? 31.641  62.214  10.230  1.00 56.29  ? 70  TRP C CZ3 1 
ATOM   8410  C CH2 . TRP C 1 70  ? 31.330  62.318  11.586  1.00 55.10  ? 70  TRP C CH2 1 
ATOM   8411  N N   . PHE C 1 71  ? 30.780  56.813  5.523   1.00 56.72  ? 71  PHE C N   1 
ATOM   8412  C CA  . PHE C 1 71  ? 31.216  56.032  4.371   1.00 61.71  ? 71  PHE C CA  1 
ATOM   8413  C C   . PHE C 1 71  ? 31.368  56.907  3.120   1.00 61.26  ? 71  PHE C C   1 
ATOM   8414  O O   . PHE C 1 71  ? 30.413  57.521  2.652   1.00 63.22  ? 71  PHE C O   1 
ATOM   8415  C CB  . PHE C 1 71  ? 30.224  54.884  4.139   1.00 70.06  ? 71  PHE C CB  1 
ATOM   8416  C CG  . PHE C 1 71  ? 30.559  53.977  2.958   1.00 75.20  ? 71  PHE C CG  1 
ATOM   8417  C CD1 . PHE C 1 71  ? 31.646  53.115  3.005   1.00 74.60  ? 71  PHE C CD1 1 
ATOM   8418  C CD2 . PHE C 1 71  ? 29.770  53.966  1.812   1.00 73.34  ? 71  PHE C CD2 1 
ATOM   8419  C CE1 . PHE C 1 71  ? 31.936  52.278  1.937   1.00 75.42  ? 71  PHE C CE1 1 
ATOM   8420  C CE2 . PHE C 1 71  ? 30.073  53.137  0.743   1.00 73.52  ? 71  PHE C CE2 1 
ATOM   8421  C CZ  . PHE C 1 71  ? 31.151  52.292  0.810   1.00 74.42  ? 71  PHE C CZ  1 
ATOM   8422  N N   . LEU C 1 72  ? 32.580  56.920  2.556   1.00 65.89  ? 72  LEU C N   1 
ATOM   8423  C CA  . LEU C 1 72  ? 32.878  57.644  1.330   1.00 73.16  ? 72  LEU C CA  1 
ATOM   8424  C C   . LEU C 1 72  ? 32.799  56.686  0.143   1.00 71.74  ? 72  LEU C C   1 
ATOM   8425  O O   . LEU C 1 72  ? 33.566  55.734  0.074   1.00 66.26  ? 72  LEU C O   1 
ATOM   8426  C CB  . LEU C 1 72  ? 34.275  58.238  1.460   1.00 69.33  ? 72  LEU C CB  1 
ATOM   8427  C CG  . LEU C 1 72  ? 34.456  59.286  2.559   1.00 71.60  ? 72  LEU C CG  1 
ATOM   8428  C CD1 . LEU C 1 72  ? 35.924  59.366  2.912   1.00 76.36  ? 72  LEU C CD1 1 
ATOM   8429  C CD2 . LEU C 1 72  ? 33.921  60.634  2.113   1.00 72.49  ? 72  LEU C CD2 1 
ATOM   8430  N N   . PRO C 1 73  ? 31.871  56.885  -0.820  1.00 73.25  ? 73  PRO C N   1 
ATOM   8431  C CA  . PRO C 1 73  ? 31.693  55.921  -1.913  1.00 75.46  ? 73  PRO C CA  1 
ATOM   8432  C C   . PRO C 1 73  ? 32.783  56.016  -2.981  1.00 66.23  ? 73  PRO C C   1 
ATOM   8433  O O   . PRO C 1 73  ? 33.129  57.118  -3.393  1.00 54.40  ? 73  PRO C O   1 
ATOM   8434  C CB  . PRO C 1 73  ? 30.298  56.302  -2.441  1.00 72.10  ? 73  PRO C CB  1 
ATOM   8435  C CG  . PRO C 1 73  ? 30.225  57.796  -2.226  1.00 72.06  ? 73  PRO C CG  1 
ATOM   8436  C CD  . PRO C 1 73  ? 30.945  58.024  -0.903  1.00 71.19  ? 73  PRO C CD  1 
ATOM   8437  N N   . ARG C 1 74  ? 33.319  54.860  -3.410  1.00 64.63  ? 74  ARG C N   1 
ATOM   8438  C CA  . ARG C 1 74  ? 34.435  54.821  -4.350  1.00 72.68  ? 74  ARG C CA  1 
ATOM   8439  C C   . ARG C 1 74  ? 34.020  54.190  -5.682  1.00 71.42  ? 74  ARG C C   1 
ATOM   8440  O O   . ARG C 1 74  ? 34.863  54.062  -6.575  1.00 66.97  ? 74  ARG C O   1 
ATOM   8441  C CB  . ARG C 1 74  ? 35.637  54.120  -3.695  1.00 77.30  ? 74  ARG C CB  1 
ATOM   8442  C CG  . ARG C 1 74  ? 36.467  55.023  -2.788  1.00 84.77  ? 74  ARG C CG  1 
ATOM   8443  C CD  . ARG C 1 74  ? 37.370  54.308  -1.769  1.00 90.76  ? 74  ARG C CD  1 
ATOM   8444  N NE  . ARG C 1 74  ? 38.351  55.229  -1.171  1.00 99.56  ? 74  ARG C NE  1 
ATOM   8445  C CZ  . ARG C 1 74  ? 38.076  56.299  -0.418  1.00 108.98 ? 74  ARG C CZ  1 
ATOM   8446  N NH1 . ARG C 1 74  ? 36.838  56.521  -0.017  1.00 118.78 ? 74  ARG C NH1 1 
ATOM   8447  N NH2 . ARG C 1 74  ? 39.029  57.137  -0.038  1.00 104.82 ? 74  ARG C NH2 1 
ATOM   8448  N N   . SER C 1 75  ? 32.724  53.844  -5.815  1.00 62.83  ? 75  SER C N   1 
ATOM   8449  C CA  . SER C 1 75  ? 32.170  53.219  -7.010  1.00 64.38  ? 75  SER C CA  1 
ATOM   8450  C C   . SER C 1 75  ? 30.669  53.474  -7.082  1.00 66.02  ? 75  SER C C   1 
ATOM   8451  O O   . SER C 1 75  ? 30.063  53.902  -6.105  1.00 69.01  ? 75  SER C O   1 
ATOM   8452  C CB  . SER C 1 75  ? 32.415  51.729  -7.048  1.00 61.50  ? 75  SER C CB  1 
ATOM   8453  O OG  . SER C 1 75  ? 31.691  51.077  -6.010  1.00 58.98  ? 75  SER C OG  1 
ATOM   8454  N N   . LYS C 1 76  ? 30.083  53.136  -8.235  1.00 67.88  ? 76  LYS C N   1 
ATOM   8455  C CA  . LYS C 1 76  ? 28.644  53.201  -8.437  1.00 67.96  ? 76  LYS C CA  1 
ATOM   8456  C C   . LYS C 1 76  ? 27.939  52.339  -7.390  1.00 69.78  ? 76  LYS C C   1 
ATOM   8457  O O   . LYS C 1 76  ? 26.943  52.762  -6.808  1.00 69.97  ? 76  LYS C O   1 
ATOM   8458  C CB  . LYS C 1 76  ? 28.343  52.781  -9.881  1.00 66.62  ? 76  LYS C CB  1 
ATOM   8459  C CG  . LYS C 1 76  ? 26.903  52.977  -10.363 1.00 70.21  ? 76  LYS C CG  1 
ATOM   8460  C CD  . LYS C 1 76  ? 26.676  52.638  -11.836 1.00 68.48  ? 76  LYS C CD  1 
ATOM   8461  C CE  . LYS C 1 76  ? 27.334  53.645  -12.734 1.00 78.79  ? 76  LYS C CE  1 
ATOM   8462  N NZ  . LYS C 1 76  ? 27.395  53.246  -14.144 1.00 78.80  ? 76  LYS C NZ  1 
ATOM   8463  N N   . ALA C 1 77  ? 28.487  51.142  -7.140  1.00 66.79  ? 77  ALA C N   1 
ATOM   8464  C CA  . ALA C 1 77  ? 27.906  50.186  -6.205  1.00 67.90  ? 77  ALA C CA  1 
ATOM   8465  C C   . ALA C 1 77  ? 27.911  50.751  -4.780  1.00 62.59  ? 77  ALA C C   1 
ATOM   8466  O O   . ALA C 1 77  ? 26.973  50.527  -4.017  1.00 55.39  ? 77  ALA C O   1 
ATOM   8467  C CB  . ALA C 1 77  ? 28.647  48.850  -6.298  1.00 56.27  ? 77  ALA C CB  1 
ATOM   8468  N N   . ASP C 1 78  ? 28.973  51.480  -4.428  1.00 59.43  ? 78  ASP C N   1 
ATOM   8469  C CA  . ASP C 1 78  ? 29.054  52.157  -3.144  1.00 71.98  ? 78  ASP C CA  1 
ATOM   8470  C C   . ASP C 1 78  ? 27.960  53.225  -3.039  1.00 67.29  ? 78  ASP C C   1 
ATOM   8471  O O   . ASP C 1 78  ? 27.262  53.307  -2.026  1.00 59.02  ? 78  ASP C O   1 
ATOM   8472  C CB  . ASP C 1 78  ? 30.449  52.717  -2.905  1.00 74.61  ? 78  ASP C CB  1 
ATOM   8473  C CG  . ASP C 1 78  ? 31.547  51.681  -2.687  1.00 70.72  ? 78  ASP C CG  1 
ATOM   8474  O OD1 . ASP C 1 78  ? 31.214  50.480  -2.577  1.00 69.62  ? 78  ASP C OD1 1 
ATOM   8475  O OD2 . ASP C 1 78  ? 32.728  52.088  -2.612  1.00 70.79  ? 78  ASP C OD2 1 
ATOM   8476  N N   . ALA C 1 79  ? 27.807  54.021  -4.104  1.00 61.73  ? 79  ALA C N   1 
ATOM   8477  C CA  . ALA C 1 79  ? 26.751  55.019  -4.190  1.00 61.14  ? 79  ALA C CA  1 
ATOM   8478  C C   . ALA C 1 79  ? 25.365  54.391  -3.993  1.00 59.05  ? 79  ALA C C   1 
ATOM   8479  O O   . ALA C 1 79  ? 24.556  54.929  -3.239  1.00 56.26  ? 79  ALA C O   1 
ATOM   8480  C CB  . ALA C 1 79  ? 26.859  55.752  -5.508  1.00 65.77  ? 79  ALA C CB  1 
ATOM   8481  N N   . ALA C 1 80  ? 25.104  53.229  -4.616  1.00 59.08  ? 80  ALA C N   1 
ATOM   8482  C CA  . ALA C 1 80  ? 23.816  52.550  -4.472  1.00 63.41  ? 80  ALA C CA  1 
ATOM   8483  C C   . ALA C 1 80  ? 23.608  52.051  -3.039  1.00 64.34  ? 80  ALA C C   1 
ATOM   8484  O O   . ALA C 1 80  ? 22.466  51.867  -2.612  1.00 63.81  ? 80  ALA C O   1 
ATOM   8485  C CB  . ALA C 1 80  ? 23.674  51.407  -5.475  1.00 56.27  ? 80  ALA C CB  1 
ATOM   8486  N N   . ARG C 1 81  ? 24.714  51.809  -2.322  1.00 62.56  ? 81  ARG C N   1 
ATOM   8487  C CA  . ARG C 1 81  ? 24.683  51.332  -0.947  1.00 65.96  ? 81  ARG C CA  1 
ATOM   8488  C C   . ARG C 1 81  ? 24.402  52.509  -0.010  1.00 62.18  ? 81  ARG C C   1 
ATOM   8489  O O   . ARG C 1 81  ? 23.691  52.365  0.982   1.00 55.51  ? 81  ARG C O   1 
ATOM   8490  C CB  . ARG C 1 81  ? 26.019  50.625  -0.679  1.00 68.72  ? 81  ARG C CB  1 
ATOM   8491  C CG  . ARG C 1 81  ? 26.120  49.828  0.610   1.00 76.55  ? 81  ARG C CG  1 
ATOM   8492  C CD  . ARG C 1 81  ? 27.508  49.224  0.755   1.00 83.78  ? 81  ARG C CD  1 
ATOM   8493  N NE  . ARG C 1 81  ? 27.845  48.905  2.149   1.00 87.23  ? 81  ARG C NE  1 
ATOM   8494  C CZ  . ARG C 1 81  ? 29.077  48.637  2.593   1.00 78.79  ? 81  ARG C CZ  1 
ATOM   8495  N NH1 . ARG C 1 81  ? 30.110  48.738  1.774   1.00 83.08  ? 81  ARG C NH1 1 
ATOM   8496  N NH2 . ARG C 1 81  ? 29.280  48.283  3.853   1.00 70.04  ? 81  ARG C NH2 1 
ATOM   8497  N N   . ARG C 1 82  ? 24.952  53.684  -0.349  1.00 61.03  ? 82  ARG C N   1 
ATOM   8498  C CA  . ARG C 1 82  ? 24.644  54.923  0.357   1.00 64.09  ? 82  ARG C CA  1 
ATOM   8499  C C   . ARG C 1 82  ? 23.192  55.340  0.129   1.00 63.77  ? 82  ARG C C   1 
ATOM   8500  O O   . ARG C 1 82  ? 22.526  55.816  1.045   1.00 63.80  ? 82  ARG C O   1 
ATOM   8501  C CB  . ARG C 1 82  ? 25.550  56.068  -0.108  1.00 61.64  ? 82  ARG C CB  1 
ATOM   8502  C CG  . ARG C 1 82  ? 26.989  55.950  0.368   1.00 59.71  ? 82  ARG C CG  1 
ATOM   8503  C CD  . ARG C 1 82  ? 27.703  57.276  0.293   1.00 63.95  ? 82  ARG C CD  1 
ATOM   8504  N NE  . ARG C 1 82  ? 26.938  58.281  1.039   1.00 64.06  ? 82  ARG C NE  1 
ATOM   8505  C CZ  . ARG C 1 82  ? 26.835  58.318  2.359   1.00 67.81  ? 82  ARG C CZ  1 
ATOM   8506  N NH1 . ARG C 1 82  ? 27.640  57.602  3.141   1.00 64.24  ? 82  ARG C NH1 1 
ATOM   8507  N NH2 . ARG C 1 82  ? 25.950  59.133  2.891   1.00 68.19  ? 82  ARG C NH2 1 
ATOM   8508  N N   . ARG C 1 83  ? 22.720  55.175  -1.113  1.00 63.30  ? 83  ARG C N   1 
ATOM   8509  C CA  . ARG C 1 83  ? 21.331  55.427  -1.443  1.00 61.55  ? 83  ARG C CA  1 
ATOM   8510  C C   . ARG C 1 83  ? 20.446  54.598  -0.513  1.00 56.88  ? 83  ARG C C   1 
ATOM   8511  O O   . ARG C 1 83  ? 19.528  55.135  0.098   1.00 53.54  ? 83  ARG C O   1 
ATOM   8512  C CB  . ARG C 1 83  ? 21.071  55.188  -2.939  1.00 63.26  ? 83  ARG C CB  1 
ATOM   8513  C CG  . ARG C 1 83  ? 19.684  55.596  -3.430  1.00 70.03  ? 83  ARG C CG  1 
ATOM   8514  C CD  . ARG C 1 83  ? 19.680  56.121  -4.862  1.00 66.44  ? 83  ARG C CD  1 
ATOM   8515  N NE  . ARG C 1 83  ? 20.236  55.084  -5.734  1.00 77.04  ? 83  ARG C NE  1 
ATOM   8516  C CZ  . ARG C 1 83  ? 19.571  54.037  -6.198  1.00 75.93  ? 83  ARG C CZ  1 
ATOM   8517  N NH1 . ARG C 1 83  ? 18.262  54.106  -6.339  1.00 75.80  ? 83  ARG C NH1 1 
ATOM   8518  N NH2 . ARG C 1 83  ? 20.229  52.971  -6.610  1.00 72.97  ? 83  ARG C NH2 1 
ATOM   8519  N N   . ALA C 1 84  ? 20.743  53.301  -0.379  1.00 54.15  ? 84  ALA C N   1 
ATOM   8520  C CA  . ALA C 1 84  ? 19.934  52.424  0.462   1.00 58.44  ? 84  ALA C CA  1 
ATOM   8521  C C   . ALA C 1 84  ? 20.026  52.831  1.932   1.00 57.35  ? 84  ALA C C   1 
ATOM   8522  O O   . ALA C 1 84  ? 19.099  52.564  2.693   1.00 63.71  ? 84  ALA C O   1 
ATOM   8523  C CB  . ALA C 1 84  ? 20.318  50.964  0.268   1.00 53.71  ? 84  ALA C CB  1 
ATOM   8524  N N   . TYR C 1 85  ? 21.151  53.447  2.327   1.00 56.29  ? 85  TYR C N   1 
ATOM   8525  C CA  . TYR C 1 85  ? 21.340  53.915  3.691   1.00 58.86  ? 85  TYR C CA  1 
ATOM   8526  C C   . TYR C 1 85  ? 20.450  55.137  3.951   1.00 60.52  ? 85  TYR C C   1 
ATOM   8527  O O   . TYR C 1 85  ? 19.804  55.240  4.994   1.00 57.60  ? 85  TYR C O   1 
ATOM   8528  C CB  . TYR C 1 85  ? 22.827  54.204  3.944   1.00 57.31  ? 85  TYR C CB  1 
ATOM   8529  C CG  . TYR C 1 85  ? 23.176  54.772  5.319   1.00 55.35  ? 85  TYR C CG  1 
ATOM   8530  C CD1 . TYR C 1 85  ? 23.140  53.986  6.462   1.00 53.45  ? 85  TYR C CD1 1 
ATOM   8531  C CD2 . TYR C 1 85  ? 23.584  56.091  5.467   1.00 55.23  ? 85  TYR C CD2 1 
ATOM   8532  C CE1 . TYR C 1 85  ? 23.492  54.491  7.705   1.00 55.06  ? 85  TYR C CE1 1 
ATOM   8533  C CE2 . TYR C 1 85  ? 23.944  56.608  6.700   1.00 56.81  ? 85  TYR C CE2 1 
ATOM   8534  C CZ  . TYR C 1 85  ? 23.894  55.808  7.827   1.00 57.13  ? 85  TYR C CZ  1 
ATOM   8535  O OH  . TYR C 1 85  ? 24.241  56.326  9.043   1.00 60.33  ? 85  TYR C OH  1 
ATOM   8536  N N   . HIS C 1 86  ? 20.429  56.080  3.006   1.00 57.42  ? 86  HIS C N   1 
ATOM   8537  C CA  . HIS C 1 86  ? 19.589  57.255  3.157   1.00 60.48  ? 86  HIS C CA  1 
ATOM   8538  C C   . HIS C 1 86  ? 18.114  56.821  3.183   1.00 59.41  ? 86  HIS C C   1 
ATOM   8539  O O   . HIS C 1 86  ? 17.337  57.327  3.991   1.00 56.39  ? 86  HIS C O   1 
ATOM   8540  C CB  . HIS C 1 86  ? 19.962  58.285  2.086   1.00 61.18  ? 86  HIS C CB  1 
ATOM   8541  C CG  . HIS C 1 86  ? 21.272  59.000  2.281   1.00 66.83  ? 86  HIS C CG  1 
ATOM   8542  N ND1 . HIS C 1 86  ? 21.625  59.707  3.416   1.00 63.20  ? 86  HIS C ND1 1 
ATOM   8543  C CD2 . HIS C 1 86  ? 22.294  59.166  1.398   1.00 63.21  ? 86  HIS C CD2 1 
ATOM   8544  C CE1 . HIS C 1 86  ? 22.820  60.258  3.225   1.00 60.65  ? 86  HIS C CE1 1 
ATOM   8545  N NE2 . HIS C 1 86  ? 23.237  59.947  2.004   1.00 57.55  ? 86  HIS C NE2 1 
ATOM   8546  N N   . GLU C 1 87  ? 17.737  55.856  2.329   1.00 59.66  ? 87  GLU C N   1 
ATOM   8547  C CA  . GLU C 1 87  ? 16.359  55.390  2.245   1.00 65.01  ? 87  GLU C CA  1 
ATOM   8548  C C   . GLU C 1 87  ? 15.954  54.759  3.575   1.00 64.67  ? 87  GLU C C   1 
ATOM   8549  O O   . GLU C 1 87  ? 14.863  55.032  4.073   1.00 65.98  ? 87  GLU C O   1 
ATOM   8550  C CB  . GLU C 1 87  ? 16.070  54.348  1.158   1.00 64.40  ? 87  GLU C CB  1 
ATOM   8551  C CG  . GLU C 1 87  ? 16.492  54.771  -0.250  1.00 68.12  ? 87  GLU C CG  1 
ATOM   8552  C CD  . GLU C 1 87  ? 15.496  54.423  -1.342  1.00 66.69  ? 87  GLU C CD  1 
ATOM   8553  O OE1 . GLU C 1 87  ? 14.366  54.039  -0.973  1.00 66.86  ? 87  GLU C OE1 1 
ATOM   8554  O OE2 . GLU C 1 87  ? 15.831  54.556  -2.540  1.00 66.58  ? 87  GLU C OE2 1 
ATOM   8555  N N   . PHE C 1 88  ? 16.821  53.903  4.136   1.00 56.19  ? 88  PHE C N   1 
ATOM   8556  C CA  . PHE C 1 88  ? 16.549  53.321  5.444   1.00 59.22  ? 88  PHE C CA  1 
ATOM   8557  C C   . PHE C 1 88  ? 16.105  54.438  6.399   1.00 54.68  ? 88  PHE C C   1 
ATOM   8558  O O   . PHE C 1 88  ? 15.077  54.320  7.058   1.00 50.21  ? 88  PHE C O   1 
ATOM   8559  C CB  . PHE C 1 88  ? 17.772  52.579  5.997   1.00 61.65  ? 88  PHE C CB  1 
ATOM   8560  C CG  . PHE C 1 88  ? 17.562  51.887  7.339   1.00 62.98  ? 88  PHE C CG  1 
ATOM   8561  C CD1 . PHE C 1 88  ? 17.527  52.616  8.525   1.00 61.62  ? 88  PHE C CD1 1 
ATOM   8562  C CD2 . PHE C 1 88  ? 17.440  50.501  7.418   1.00 62.50  ? 88  PHE C CD2 1 
ATOM   8563  C CE1 . PHE C 1 88  ? 17.348  51.983  9.746   1.00 59.80  ? 88  PHE C CE1 1 
ATOM   8564  C CE2 . PHE C 1 88  ? 17.259  49.873  8.642   1.00 61.56  ? 88  PHE C CE2 1 
ATOM   8565  C CZ  . PHE C 1 88  ? 17.212  50.617  9.803   1.00 61.53  ? 88  PHE C CZ  1 
ATOM   8566  N N   . TRP C 1 89  ? 16.871  55.539  6.442   1.00 48.59  ? 89  TRP C N   1 
ATOM   8567  C CA  . TRP C 1 89  ? 16.632  56.585  7.424   1.00 53.80  ? 89  TRP C CA  1 
ATOM   8568  C C   . TRP C 1 89  ? 15.371  57.389  7.128   1.00 54.25  ? 89  TRP C C   1 
ATOM   8569  O O   . TRP C 1 89  ? 14.646  57.671  8.072   1.00 48.73  ? 89  TRP C O   1 
ATOM   8570  C CB  . TRP C 1 89  ? 17.879  57.456  7.613   1.00 51.98  ? 89  TRP C CB  1 
ATOM   8571  C CG  . TRP C 1 89  ? 18.877  56.670  8.414   1.00 57.15  ? 89  TRP C CG  1 
ATOM   8572  C CD1 . TRP C 1 89  ? 20.106  56.209  8.038   1.00 52.15  ? 89  TRP C CD1 1 
ATOM   8573  C CD2 . TRP C 1 89  ? 18.602  56.090  9.707   1.00 53.87  ? 89  TRP C CD2 1 
ATOM   8574  N NE1 . TRP C 1 89  ? 20.638  55.432  9.034   1.00 51.21  ? 89  TRP C NE1 1 
ATOM   8575  C CE2 . TRP C 1 89  ? 19.742  55.338  10.067  1.00 52.46  ? 89  TRP C CE2 1 
ATOM   8576  C CE3 . TRP C 1 89  ? 17.517  56.148  10.593  1.00 52.41  ? 89  TRP C CE3 1 
ATOM   8577  C CZ2 . TRP C 1 89  ? 19.824  54.659  11.282  1.00 51.67  ? 89  TRP C CZ2 1 
ATOM   8578  C CZ3 . TRP C 1 89  ? 17.599  55.470  11.792  1.00 53.85  ? 89  TRP C CZ3 1 
ATOM   8579  C CH2 . TRP C 1 89  ? 18.735  54.729  12.124  1.00 57.03  ? 89  TRP C CH2 1 
ATOM   8580  N N   . PHE C 1 90  ? 15.099  57.690  5.846   1.00 53.68  ? 90  PHE C N   1 
ATOM   8581  C CA  . PHE C 1 90  ? 13.900  58.413  5.452   1.00 56.46  ? 90  PHE C CA  1 
ATOM   8582  C C   . PHE C 1 90  ? 12.672  57.562  5.767   1.00 56.43  ? 90  PHE C C   1 
ATOM   8583  O O   . PHE C 1 90  ? 11.651  58.083  6.198   1.00 56.57  ? 90  PHE C O   1 
ATOM   8584  C CB  . PHE C 1 90  ? 13.989  58.833  3.979   1.00 62.50  ? 90  PHE C CB  1 
ATOM   8585  C CG  . PHE C 1 90  ? 15.201  59.682  3.591   1.00 63.54  ? 90  PHE C CG  1 
ATOM   8586  C CD1 . PHE C 1 90  ? 15.706  60.666  4.440   1.00 67.01  ? 90  PHE C CD1 1 
ATOM   8587  C CD2 . PHE C 1 90  ? 15.842  59.489  2.367   1.00 67.22  ? 90  PHE C CD2 1 
ATOM   8588  C CE1 . PHE C 1 90  ? 16.814  61.423  4.077   1.00 68.06  ? 90  PHE C CE1 1 
ATOM   8589  C CE2 . PHE C 1 90  ? 16.960  60.240  2.016   1.00 63.60  ? 90  PHE C CE2 1 
ATOM   8590  C CZ  . PHE C 1 90  ? 17.445  61.199  2.871   1.00 65.46  ? 90  PHE C CZ  1 
ATOM   8591  N N   . ARG C 1 91  ? 12.801  56.239  5.613   1.00 61.94  ? 91  ARG C N   1 
ATOM   8592  C CA  . ARG C 1 91  ? 11.713  55.318  5.895   1.00 58.88  ? 91  ARG C CA  1 
ATOM   8593  C C   . ARG C 1 91  ? 11.515  55.190  7.404   1.00 53.41  ? 91  ARG C C   1 
ATOM   8594  O O   . ARG C 1 91  ? 10.381  55.213  7.869   1.00 53.23  ? 91  ARG C O   1 
ATOM   8595  C CB  . ARG C 1 91  ? 11.919  53.963  5.199   1.00 60.81  ? 91  ARG C CB  1 
ATOM   8596  C CG  . ARG C 1 91  ? 11.713  54.086  3.694   1.00 62.38  ? 91  ARG C CG  1 
ATOM   8597  C CD  . ARG C 1 91  ? 11.882  52.811  2.888   1.00 63.79  ? 91  ARG C CD  1 
ATOM   8598  N NE  . ARG C 1 91  ? 12.156  53.138  1.483   1.00 63.32  ? 91  ARG C NE  1 
ATOM   8599  C CZ  . ARG C 1 91  ? 11.252  53.416  0.538   1.00 66.41  ? 91  ARG C CZ  1 
ATOM   8600  N NH1 . ARG C 1 91  ? 9.955   53.201  0.746   1.00 59.66  ? 91  ARG C NH1 1 
ATOM   8601  N NH2 . ARG C 1 91  ? 11.667  53.867  -0.637  1.00 59.52  ? 91  ARG C NH2 1 
ATOM   8602  N N   . HIS C 1 92  ? 12.605  55.051  8.165   1.00 53.63  ? 92  HIS C N   1 
ATOM   8603  C CA  . HIS C 1 92  ? 12.508  54.923  9.615   1.00 60.59  ? 92  HIS C CA  1 
ATOM   8604  C C   . HIS C 1 92  ? 11.867  56.178  10.227  1.00 64.93  ? 92  HIS C C   1 
ATOM   8605  O O   . HIS C 1 92  ? 11.077  56.079  11.163  1.00 60.38  ? 92  HIS C O   1 
ATOM   8606  C CB  . HIS C 1 92  ? 13.876  54.575  10.215  1.00 58.85  ? 92  HIS C CB  1 
ATOM   8607  C CG  . HIS C 1 92  ? 13.908  54.591  11.709  1.00 66.57  ? 92  HIS C CG  1 
ATOM   8608  N ND1 . HIS C 1 92  ? 14.220  55.725  12.434  1.00 74.68  ? 92  HIS C ND1 1 
ATOM   8609  C CD2 . HIS C 1 92  ? 13.686  53.621  12.612  1.00 75.86  ? 92  HIS C CD2 1 
ATOM   8610  C CE1 . HIS C 1 92  ? 14.187  55.442  13.732  1.00 73.77  ? 92  HIS C CE1 1 
ATOM   8611  N NE2 . HIS C 1 92  ? 13.864  54.168  13.866  1.00 74.90  ? 92  HIS C NE2 1 
ATOM   8612  N N   . PHE C 1 93  ? 12.187  57.354  9.665   1.00 64.47  ? 93  PHE C N   1 
ATOM   8613  C CA  . PHE C 1 93  ? 11.584  58.619  10.063  1.00 65.43  ? 93  PHE C CA  1 
ATOM   8614  C C   . PHE C 1 93  ? 10.383  58.977  9.174   1.00 68.84  ? 93  PHE C C   1 
ATOM   8615  O O   . PHE C 1 93  ? 10.175  60.147  8.854   1.00 67.61  ? 93  PHE C O   1 
ATOM   8616  C CB  . PHE C 1 93  ? 12.657  59.712  9.969   1.00 59.61  ? 93  PHE C CB  1 
ATOM   8617  C CG  . PHE C 1 93  ? 13.792  59.640  10.980  1.00 60.88  ? 93  PHE C CG  1 
ATOM   8618  C CD1 . PHE C 1 93  ? 13.531  59.536  12.344  1.00 53.87  ? 93  PHE C CD1 1 
ATOM   8619  C CD2 . PHE C 1 93  ? 15.122  59.680  10.557  1.00 62.57  ? 93  PHE C CD2 1 
ATOM   8620  C CE1 . PHE C 1 93  ? 14.570  59.487  13.260  1.00 54.41  ? 93  PHE C CE1 1 
ATOM   8621  C CE2 . PHE C 1 93  ? 16.155  59.619  11.479  1.00 60.24  ? 93  PHE C CE2 1 
ATOM   8622  C CZ  . PHE C 1 93  ? 15.873  59.525  12.827  1.00 58.15  ? 93  PHE C CZ  1 
ATOM   8623  N N   . GLN C 1 94  ? 9.625   57.970  8.722   1.00 69.16  ? 94  GLN C N   1 
ATOM   8624  C CA  . GLN C 1 94  ? 8.247   58.148  8.291   1.00 60.24  ? 94  GLN C CA  1 
ATOM   8625  C C   . GLN C 1 94  ? 8.168   59.062  7.066   1.00 68.45  ? 94  GLN C C   1 
ATOM   8626  O O   . GLN C 1 94  ? 7.388   60.018  7.038   1.00 67.67  ? 94  GLN C O   1 
ATOM   8627  C CB  . GLN C 1 94  ? 7.455   58.655  9.500   1.00 65.73  ? 94  GLN C CB  1 
ATOM   8628  C CG  . GLN C 1 94  ? 7.750   57.896  10.794  1.00 65.87  ? 94  GLN C CG  1 
ATOM   8629  C CD  . GLN C 1 94  ? 6.537   57.653  11.674  1.00 71.16  ? 94  GLN C CD  1 
ATOM   8630  O OE1 . GLN C 1 94  ? 5.374   57.848  11.288  1.00 72.06  ? 94  GLN C OE1 1 
ATOM   8631  N NE2 . GLN C 1 94  ? 6.801   57.151  12.871  1.00 66.23  ? 94  GLN C NE2 1 
ATOM   8632  N N   . GLY C 1 95  ? 8.991   58.769  6.053   1.00 70.70  ? 95  GLY C N   1 
ATOM   8633  C CA  . GLY C 1 95  ? 8.941   59.479  4.784   1.00 76.02  ? 95  GLY C CA  1 
ATOM   8634  C C   . GLY C 1 95  ? 9.981   60.592  4.715   1.00 69.52  ? 95  GLY C C   1 
ATOM   8635  O O   . GLY C 1 95  ? 10.378  61.014  3.627   1.00 70.10  ? 95  GLY C O   1 
ATOM   8636  N N   . GLY C 1 96  ? 10.406  61.055  5.894   1.00 71.13  ? 96  GLY C N   1 
ATOM   8637  C CA  . GLY C 1 96  ? 11.514  61.994  6.011   1.00 75.75  ? 96  GLY C CA  1 
ATOM   8638  C C   . GLY C 1 96  ? 11.133  63.235  6.815   1.00 65.89  ? 96  GLY C C   1 
ATOM   8639  O O   . GLY C 1 96  ? 11.459  64.339  6.397   1.00 65.67  ? 96  GLY C O   1 
ATOM   8640  N N   . ILE C 1 97  ? 10.469  63.018  7.965   1.00 64.44  ? 97  ILE C N   1 
ATOM   8641  C CA  . ILE C 1 97  ? 9.973   64.082  8.822   1.00 64.29  ? 97  ILE C CA  1 
ATOM   8642  C C   . ILE C 1 97  ? 11.167  64.791  9.460   1.00 67.02  ? 97  ILE C C   1 
ATOM   8643  O O   . ILE C 1 97  ? 11.128  66.013  9.639   1.00 61.28  ? 97  ILE C O   1 
ATOM   8644  C CB  . ILE C 1 97  ? 8.954   63.573  9.871   1.00 63.70  ? 97  ILE C CB  1 
ATOM   8645  C CG1 . ILE C 1 97  ? 9.574   62.700  10.989  1.00 59.63  ? 97  ILE C CG1 1 
ATOM   8646  C CG2 . ILE C 1 97  ? 7.785   62.872  9.181   1.00 64.48  ? 97  ILE C CG2 1 
ATOM   8647  C CD1 . ILE C 1 97  ? 8.654   62.447  12.181  1.00 56.66  ? 97  ILE C CD1 1 
ATOM   8648  N N   . PHE C 1 98  ? 12.213  64.011  9.782   1.00 59.54  ? 98  PHE C N   1 
ATOM   8649  C CA  . PHE C 1 98  ? 13.496  64.555  10.199  1.00 57.00  ? 98  PHE C CA  1 
ATOM   8650  C C   . PHE C 1 98  ? 14.460  64.442  9.024   1.00 54.39  ? 98  PHE C C   1 
ATOM   8651  O O   . PHE C 1 98  ? 14.824  63.342  8.629   1.00 58.96  ? 98  PHE C O   1 
ATOM   8652  C CB  . PHE C 1 98  ? 13.965  63.830  11.464  1.00 57.05  ? 98  PHE C CB  1 
ATOM   8653  C CG  . PHE C 1 98  ? 12.986  63.870  12.629  1.00 55.20  ? 98  PHE C CG  1 
ATOM   8654  C CD1 . PHE C 1 98  ? 12.044  64.893  12.755  1.00 59.34  ? 98  PHE C CD1 1 
ATOM   8655  C CD2 . PHE C 1 98  ? 13.010  62.885  13.607  1.00 50.58  ? 98  PHE C CD2 1 
ATOM   8656  C CE1 . PHE C 1 98  ? 11.141  64.912  13.814  1.00 61.84  ? 98  PHE C CE1 1 
ATOM   8657  C CE2 . PHE C 1 98  ? 12.107  62.913  14.665  1.00 56.66  ? 98  PHE C CE2 1 
ATOM   8658  C CZ  . PHE C 1 98  ? 11.177  63.922  14.768  1.00 57.66  ? 98  PHE C CZ  1 
ATOM   8659  N N   . THR C 1 99  ? 14.852  65.601  8.480   1.00 65.75  ? 99  THR C N   1 
ATOM   8660  C CA  . THR C 1 99  ? 15.581  65.705  7.224   1.00 71.81  ? 99  THR C CA  1 
ATOM   8661  C C   . THR C 1 99  ? 17.090  65.649  7.473   1.00 73.49  ? 99  THR C C   1 
ATOM   8662  O O   . THR C 1 99  ? 17.860  65.422  6.535   1.00 77.48  ? 99  THR C O   1 
ATOM   8663  C CB  . THR C 1 99  ? 15.187  66.998  6.492   1.00 75.40  ? 99  THR C CB  1 
ATOM   8664  O OG1 . THR C 1 99  ? 15.321  68.109  7.376   1.00 67.26  ? 99  THR C OG1 1 
ATOM   8665  C CG2 . THR C 1 99  ? 13.758  66.980  5.974   1.00 76.05  ? 99  THR C CG2 1 
ATOM   8666  N N   . ARG C 1 100 ? 17.503  65.824  8.738   1.00 67.72  ? 100 ARG C N   1 
ATOM   8667  C CA  . ARG C 1 100 ? 18.897  66.078  9.064   1.00 69.66  ? 100 ARG C CA  1 
ATOM   8668  C C   . ARG C 1 100 ? 19.331  65.301  10.299  1.00 63.95  ? 100 ARG C C   1 
ATOM   8669  O O   . ARG C 1 100 ? 19.778  65.904  11.269  1.00 57.40  ? 100 ARG C O   1 
ATOM   8670  C CB  . ARG C 1 100 ? 19.101  67.574  9.347   1.00 78.02  ? 100 ARG C CB  1 
ATOM   8671  C CG  . ARG C 1 100 ? 19.128  68.476  8.122   1.00 79.66  ? 100 ARG C CG  1 
ATOM   8672  C CD  . ARG C 1 100 ? 20.293  68.109  7.214   1.00 88.25  ? 100 ARG C CD  1 
ATOM   8673  N NE  . ARG C 1 100 ? 20.490  69.098  6.153   1.00 87.01  ? 100 ARG C NE  1 
ATOM   8674  C CZ  . ARG C 1 100 ? 20.096  68.940  4.899   1.00 100.86 ? 100 ARG C CZ  1 
ATOM   8675  N NH1 . ARG C 1 100 ? 19.473  67.833  4.505   1.00 101.98 ? 100 ARG C NH1 1 
ATOM   8676  N NH2 . ARG C 1 100 ? 20.318  69.922  4.049   1.00 97.97  ? 100 ARG C NH2 1 
ATOM   8677  N N   . PRO C 1 101 ? 19.243  63.952  10.305  1.00 65.39  ? 101 PRO C N   1 
ATOM   8678  C CA  . PRO C 1 101 ? 20.004  63.157  11.268  1.00 64.14  ? 101 PRO C CA  1 
ATOM   8679  C C   . PRO C 1 101 ? 21.478  63.337  10.895  1.00 67.93  ? 101 PRO C C   1 
ATOM   8680  O O   . PRO C 1 101 ? 21.783  63.994  9.901   1.00 67.96  ? 101 PRO C O   1 
ATOM   8681  C CB  . PRO C 1 101 ? 19.501  61.718  11.065  1.00 70.64  ? 101 PRO C CB  1 
ATOM   8682  C CG  . PRO C 1 101 ? 18.950  61.708  9.643   1.00 73.96  ? 101 PRO C CG  1 
ATOM   8683  C CD  . PRO C 1 101 ? 18.457  63.131  9.367   1.00 68.04  ? 101 PRO C CD  1 
ATOM   8684  N N   . PRO C 1 102 ? 22.453  62.795  11.663  1.00 67.41  ? 102 PRO C N   1 
ATOM   8685  C CA  . PRO C 1 102 ? 23.848  62.738  11.197  1.00 68.55  ? 102 PRO C CA  1 
ATOM   8686  C C   . PRO C 1 102 ? 24.107  62.236  9.770   1.00 70.58  ? 102 PRO C C   1 
ATOM   8687  O O   . PRO C 1 102 ? 25.034  62.715  9.123   1.00 58.17  ? 102 PRO C O   1 
ATOM   8688  C CB  . PRO C 1 102 ? 24.451  61.812  12.254  1.00 65.19  ? 102 PRO C CB  1 
ATOM   8689  C CG  . PRO C 1 102 ? 23.726  62.225  13.508  1.00 63.78  ? 102 PRO C CG  1 
ATOM   8690  C CD  . PRO C 1 102 ? 22.282  62.310  13.042  1.00 64.70  ? 102 PRO C CD  1 
ATOM   8691  N N   . ALA C 1 103 ? 23.265  61.301  9.286   1.00 73.83  ? 103 ALA C N   1 
ATOM   8692  C CA  . ALA C 1 103 ? 23.382  60.719  7.954   1.00 72.77  ? 103 ALA C CA  1 
ATOM   8693  C C   . ALA C 1 103 ? 23.243  61.771  6.852   1.00 70.51  ? 103 ALA C C   1 
ATOM   8694  O O   . ALA C 1 103 ? 23.921  61.665  5.829   1.00 64.01  ? 103 ALA C O   1 
ATOM   8695  C CB  . ALA C 1 103 ? 22.353  59.618  7.779   1.00 70.54  ? 103 ALA C CB  1 
ATOM   8696  N N   . GLY C 1 104 ? 22.357  62.760  7.066   1.00 67.30  ? 104 GLY C N   1 
ATOM   8697  C CA  . GLY C 1 104 ? 22.090  63.814  6.095   1.00 72.05  ? 104 GLY C CA  1 
ATOM   8698  C C   . GLY C 1 104 ? 23.056  64.994  6.221   1.00 68.10  ? 104 GLY C C   1 
ATOM   8699  O O   . GLY C 1 104 ? 23.374  65.651  5.240   1.00 72.54  ? 104 GLY C O   1 
ATOM   8700  N N   . MET C 1 105 ? 23.536  65.247  7.435   1.00 65.71  ? 105 MET C N   1 
ATOM   8701  C CA  . MET C 1 105 ? 24.321  66.433  7.730   1.00 70.30  ? 105 MET C CA  1 
ATOM   8702  C C   . MET C 1 105 ? 25.804  66.216  7.429   1.00 65.45  ? 105 MET C C   1 
ATOM   8703  O O   . MET C 1 105 ? 26.484  67.153  7.024   1.00 70.88  ? 105 MET C O   1 
ATOM   8704  C CB  . MET C 1 105 ? 24.185  66.798  9.211   1.00 75.87  ? 105 MET C CB  1 
ATOM   8705  C CG  . MET C 1 105 ? 22.751  66.979  9.674   1.00 79.71  ? 105 MET C CG  1 
ATOM   8706  S SD  . MET C 1 105 ? 22.589  66.868  11.470  1.00 83.90  ? 105 MET C SD  1 
ATOM   8707  C CE  . MET C 1 105 ? 23.446  68.417  11.711  1.00 66.68  ? 105 MET C CE  1 
ATOM   8708  N N   . HIS C 1 106 ? 26.310  64.990  7.620   1.00 65.93  ? 106 HIS C N   1 
ATOM   8709  C CA  . HIS C 1 106 ? 27.749  64.737  7.576   1.00 73.46  ? 106 HIS C CA  1 
ATOM   8710  C C   . HIS C 1 106 ? 28.317  64.785  6.153   1.00 75.51  ? 106 HIS C C   1 
ATOM   8711  O O   . HIS C 1 106 ? 29.536  64.926  5.999   1.00 69.77  ? 106 HIS C O   1 
ATOM   8712  C CB  . HIS C 1 106 ? 28.097  63.413  8.274   1.00 70.89  ? 106 HIS C CB  1 
ATOM   8713  C CG  . HIS C 1 106 ? 27.934  63.466  9.758   1.00 70.14  ? 106 HIS C CG  1 
ATOM   8714  N ND1 . HIS C 1 106 ? 27.894  62.330  10.536  1.00 67.07  ? 106 HIS C ND1 1 
ATOM   8715  C CD2 . HIS C 1 106 ? 27.828  64.512  10.609  1.00 64.42  ? 106 HIS C CD2 1 
ATOM   8716  C CE1 . HIS C 1 106 ? 27.754  62.685  11.811  1.00 69.82  ? 106 HIS C CE1 1 
ATOM   8717  N NE2 . HIS C 1 106 ? 27.702  64.003  11.875  1.00 62.52  ? 106 HIS C NE2 1 
ATOM   8718  N N   . VAL C 1 107 ? 27.428  64.697  5.143   1.00 72.04  ? 107 VAL C N   1 
ATOM   8719  C CA  . VAL C 1 107 ? 27.792  64.525  3.744   1.00 69.36  ? 107 VAL C CA  1 
ATOM   8720  C C   . VAL C 1 107 ? 28.518  65.766  3.215   1.00 77.55  ? 107 VAL C C   1 
ATOM   8721  O O   . VAL C 1 107 ? 29.162  65.679  2.164   1.00 70.39  ? 107 VAL C O   1 
ATOM   8722  C CB  . VAL C 1 107 ? 26.587  64.183  2.834   1.00 76.00  ? 107 VAL C CB  1 
ATOM   8723  C CG1 . VAL C 1 107 ? 25.936  62.838  3.167   1.00 69.82  ? 107 VAL C CG1 1 
ATOM   8724  C CG2 . VAL C 1 107 ? 25.545  65.299  2.805   1.00 74.62  ? 107 VAL C CG2 1 
ATOM   8725  N N   . VAL C 1 108 ? 28.416  66.904  3.935   1.00 80.57  ? 108 VAL C N   1 
ATOM   8726  C CA  . VAL C 1 108 ? 29.101  68.143  3.567   1.00 84.15  ? 108 VAL C CA  1 
ATOM   8727  C C   . VAL C 1 108 ? 30.618  67.937  3.594   1.00 77.59  ? 108 VAL C C   1 
ATOM   8728  O O   . VAL C 1 108 ? 31.343  68.488  2.765   1.00 72.68  ? 108 VAL C O   1 
ATOM   8729  C CB  . VAL C 1 108 ? 28.720  69.355  4.448   1.00 84.70  ? 108 VAL C CB  1 
ATOM   8730  C CG1 . VAL C 1 108 ? 27.231  69.666  4.370   1.00 88.91  ? 108 VAL C CG1 1 
ATOM   8731  C CG2 . VAL C 1 108 ? 29.159  69.191  5.903   1.00 80.44  ? 108 VAL C CG2 1 
ATOM   8732  N N   . MET C 1 109 ? 31.101  67.147  4.556   1.00 75.39  ? 109 MET C N   1 
ATOM   8733  C CA  . MET C 1 109 ? 32.535  66.991  4.732   1.00 78.73  ? 109 MET C CA  1 
ATOM   8734  C C   . MET C 1 109 ? 33.134  66.167  3.596   1.00 71.44  ? 109 MET C C   1 
ATOM   8735  O O   . MET C 1 109 ? 34.331  66.262  3.352   1.00 69.79  ? 109 MET C O   1 
ATOM   8736  C CB  . MET C 1 109 ? 32.873  66.285  6.046   1.00 70.70  ? 109 MET C CB  1 
ATOM   8737  C CG  . MET C 1 109 ? 32.324  66.972  7.257   1.00 73.58  ? 109 MET C CG  1 
ATOM   8738  S SD  . MET C 1 109 ? 33.177  66.367  8.721   1.00 82.23  ? 109 MET C SD  1 
ATOM   8739  C CE  . MET C 1 109 ? 34.803  67.116  8.492   1.00 77.85  ? 109 MET C CE  1 
ATOM   8740  N N   . TYR C 1 110 ? 32.313  65.345  2.930   1.00 65.54  ? 110 TYR C N   1 
ATOM   8741  C CA  . TYR C 1 110 ? 32.826  64.329  2.021   1.00 71.45  ? 110 TYR C CA  1 
ATOM   8742  C C   . TYR C 1 110 ? 33.694  64.956  0.927   1.00 70.09  ? 110 TYR C C   1 
ATOM   8743  O O   . TYR C 1 110 ? 34.731  64.395  0.583   1.00 70.42  ? 110 TYR C O   1 
ATOM   8744  C CB  . TYR C 1 110 ? 31.716  63.484  1.387   1.00 73.49  ? 110 TYR C CB  1 
ATOM   8745  C CG  . TYR C 1 110 ? 30.878  62.633  2.338   1.00 74.45  ? 110 TYR C CG  1 
ATOM   8746  C CD1 . TYR C 1 110 ? 31.176  62.506  3.701   1.00 66.72  ? 110 TYR C CD1 1 
ATOM   8747  C CD2 . TYR C 1 110 ? 29.792  61.918  1.844   1.00 67.24  ? 110 TYR C CD2 1 
ATOM   8748  C CE1 . TYR C 1 110 ? 30.403  61.712  4.538   1.00 63.51  ? 110 TYR C CE1 1 
ATOM   8749  C CE2 . TYR C 1 110 ? 29.024  61.113  2.669   1.00 74.25  ? 110 TYR C CE2 1 
ATOM   8750  C CZ  . TYR C 1 110 ? 29.320  61.018  4.019   1.00 67.55  ? 110 TYR C CZ  1 
ATOM   8751  O OH  . TYR C 1 110 ? 28.505  60.233  4.783   1.00 60.05  ? 110 TYR C OH  1 
ATOM   8752  N N   . ALA C 1 111 ? 33.286  66.114  0.389   1.00 76.19  ? 111 ALA C N   1 
ATOM   8753  C CA  . ALA C 1 111 ? 34.034  66.749  -0.693  1.00 74.71  ? 111 ALA C CA  1 
ATOM   8754  C C   . ALA C 1 111 ? 35.371  67.286  -0.174  1.00 74.38  ? 111 ALA C C   1 
ATOM   8755  O O   . ALA C 1 111 ? 36.361  67.336  -0.918  1.00 65.73  ? 111 ALA C O   1 
ATOM   8756  C CB  . ALA C 1 111 ? 33.196  67.839  -1.340  1.00 68.66  ? 111 ALA C CB  1 
ATOM   8757  N N   . GLN C 1 112 ? 35.377  67.675  1.113   1.00 75.18  ? 112 GLN C N   1 
ATOM   8758  C CA  . GLN C 1 112 ? 36.538  68.282  1.750   1.00 77.15  ? 112 GLN C CA  1 
ATOM   8759  C C   . GLN C 1 112 ? 37.698  67.300  1.880   1.00 74.75  ? 112 GLN C C   1 
ATOM   8760  O O   . GLN C 1 112 ? 38.824  67.664  1.562   1.00 66.02  ? 112 GLN C O   1 
ATOM   8761  C CB  . GLN C 1 112 ? 36.280  68.746  3.178   1.00 70.99  ? 112 GLN C CB  1 
ATOM   8762  C CG  . GLN C 1 112 ? 35.292  69.892  3.298   1.00 75.89  ? 112 GLN C CG  1 
ATOM   8763  C CD  . GLN C 1 112 ? 35.416  70.551  4.650   1.00 79.68  ? 112 GLN C CD  1 
ATOM   8764  O OE1 . GLN C 1 112 ? 35.392  69.872  5.685   1.00 85.44  ? 112 GLN C OE1 1 
ATOM   8765  N NE2 . GLN C 1 112 ? 35.638  71.859  4.640   1.00 75.07  ? 112 GLN C NE2 1 
ATOM   8766  N N   . ILE C 1 113 ? 37.418  66.096  2.405   1.00 75.00  ? 113 ILE C N   1 
ATOM   8767  C CA  . ILE C 1 113 ? 38.435  65.083  2.653   1.00 79.86  ? 113 ILE C CA  1 
ATOM   8768  C C   . ILE C 1 113 ? 38.856  64.400  1.349   1.00 83.55  ? 113 ILE C C   1 
ATOM   8769  O O   . ILE C 1 113 ? 39.967  63.869  1.265   1.00 74.87  ? 113 ILE C O   1 
ATOM   8770  C CB  . ILE C 1 113 ? 37.943  64.041  3.674   1.00 83.24  ? 113 ILE C CB  1 
ATOM   8771  C CG1 . ILE C 1 113 ? 36.756  63.265  3.125   1.00 89.21  ? 113 ILE C CG1 1 
ATOM   8772  C CG2 . ILE C 1 113 ? 37.638  64.682  5.025   1.00 86.51  ? 113 ILE C CG2 1 
ATOM   8773  C CD1 . ILE C 1 113 ? 36.099  62.363  4.138   1.00 93.17  ? 113 ILE C CD1 1 
ATOM   8774  N N   . ASP C 1 114 ? 37.950  64.358  0.360   1.00 83.75  ? 114 ASP C N   1 
ATOM   8775  C CA  . ASP C 1 114 ? 38.302  63.883  -0.970  1.00 87.95  ? 114 ASP C CA  1 
ATOM   8776  C C   . ASP C 1 114 ? 39.419  64.753  -1.554  1.00 90.52  ? 114 ASP C C   1 
ATOM   8777  O O   . ASP C 1 114 ? 40.396  64.224  -2.105  1.00 80.64  ? 114 ASP C O   1 
ATOM   8778  C CB  . ASP C 1 114 ? 37.105  63.860  -1.909  1.00 87.41  ? 114 ASP C CB  1 
ATOM   8779  C CG  . ASP C 1 114 ? 37.422  63.378  -3.319  1.00 84.65  ? 114 ASP C CG  1 
ATOM   8780  O OD1 . ASP C 1 114 ? 37.776  62.185  -3.451  1.00 83.16  ? 114 ASP C OD1 1 
ATOM   8781  O OD2 . ASP C 1 114 ? 37.353  64.202  -4.266  1.00 84.73  ? 114 ASP C OD2 1 
ATOM   8782  N N   . ASP C 1 115 ? 39.269  66.084  -1.408  1.00 81.96  ? 115 ASP C N   1 
ATOM   8783  C CA  . ASP C 1 115 ? 40.192  67.036  -2.007  1.00 78.54  ? 115 ASP C CA  1 
ATOM   8784  C C   . ASP C 1 115 ? 40.662  68.081  -0.988  1.00 73.99  ? 115 ASP C C   1 
ATOM   8785  O O   . ASP C 1 115 ? 40.287  69.248  -1.099  1.00 67.95  ? 115 ASP C O   1 
ATOM   8786  C CB  . ASP C 1 115 ? 39.551  67.676  -3.228  1.00 79.01  ? 115 ASP C CB  1 
ATOM   8787  C CG  . ASP C 1 115 ? 40.489  68.525  -4.068  1.00 78.06  ? 115 ASP C CG  1 
ATOM   8788  O OD1 . ASP C 1 115 ? 41.715  68.334  -3.940  1.00 77.80  ? 115 ASP C OD1 1 
ATOM   8789  O OD2 . ASP C 1 115 ? 39.984  69.400  -4.800  1.00 84.84  ? 115 ASP C OD2 1 
ATOM   8790  N N   . PRO C 1 116 ? 41.535  67.732  -0.002  1.00 71.90  ? 116 PRO C N   1 
ATOM   8791  C CA  . PRO C 1 116 ? 41.944  68.685  1.037   1.00 77.76  ? 116 PRO C CA  1 
ATOM   8792  C C   . PRO C 1 116 ? 42.927  69.805  0.645   1.00 86.34  ? 116 PRO C C   1 
ATOM   8793  O O   . PRO C 1 116 ? 42.859  70.902  1.215   1.00 75.28  ? 116 PRO C O   1 
ATOM   8794  C CB  . PRO C 1 116 ? 42.519  67.774  2.183   1.00 78.08  ? 116 PRO C CB  1 
ATOM   8795  C CG  . PRO C 1 116 ? 42.488  66.341  1.670   1.00 74.60  ? 116 PRO C CG  1 
ATOM   8796  C CD  . PRO C 1 116 ? 42.156  66.408  0.185   1.00 77.03  ? 116 PRO C CD  1 
ATOM   8797  N N   . GLU C 1 117 ? 43.830  69.543  -0.324  1.00 89.60  ? 117 GLU C N   1 
ATOM   8798  C CA  . GLU C 1 117 ? 45.011  70.377  -0.540  1.00 77.45  ? 117 GLU C CA  1 
ATOM   8799  C C   . GLU C 1 117 ? 44.603  71.803  -0.930  1.00 79.28  ? 117 GLU C C   1 
ATOM   8800  O O   . GLU C 1 117 ? 45.123  72.763  -0.352  1.00 69.02  ? 117 GLU C O   1 
ATOM   8801  C CB  . GLU C 1 117 ? 46.021  69.809  -1.547  1.00 86.83  ? 117 GLU C CB  1 
ATOM   8802  C CG  . GLU C 1 117 ? 46.595  68.425  -1.226  1.00 85.87  ? 117 GLU C CG  1 
ATOM   8803  C CD  . GLU C 1 117 ? 47.133  68.174  0.178   1.00 88.46  ? 117 GLU C CD  1 
ATOM   8804  O OE1 . GLU C 1 117 ? 47.783  69.078  0.759   1.00 82.55  ? 117 GLU C OE1 1 
ATOM   8805  O OE2 . GLU C 1 117 ? 46.917  67.042  0.682   1.00 76.32  ? 117 GLU C OE2 1 
ATOM   8806  N N   . PRO C 1 118 ? 43.660  72.012  -1.889  1.00 76.75  ? 118 PRO C N   1 
ATOM   8807  C CA  . PRO C 1 118 ? 43.255  73.372  -2.274  1.00 67.80  ? 118 PRO C CA  1 
ATOM   8808  C C   . PRO C 1 118 ? 42.647  74.226  -1.155  1.00 74.26  ? 118 PRO C C   1 
ATOM   8809  O O   . PRO C 1 118 ? 42.585  75.449  -1.292  1.00 72.32  ? 118 PRO C O   1 
ATOM   8810  C CB  . PRO C 1 118 ? 42.241  73.169  -3.441  1.00 68.05  ? 118 PRO C CB  1 
ATOM   8811  C CG  . PRO C 1 118 ? 42.392  71.716  -3.857  1.00 74.46  ? 118 PRO C CG  1 
ATOM   8812  C CD  . PRO C 1 118 ? 42.933  70.969  -2.638  1.00 71.20  ? 118 PRO C CD  1 
ATOM   8813  N N   . TRP C 1 119 ? 42.155  73.589  -0.073  1.00 78.53  ? 119 TRP C N   1 
ATOM   8814  C CA  . TRP C 1 119 ? 41.677  74.310  1.100   1.00 82.97  ? 119 TRP C CA  1 
ATOM   8815  C C   . TRP C 1 119 ? 42.849  75.022  1.773   1.00 99.29  ? 119 TRP C C   1 
ATOM   8816  O O   . TRP C 1 119 ? 42.715  76.183  2.179   1.00 88.53  ? 119 TRP C O   1 
ATOM   8817  C CB  . TRP C 1 119 ? 40.934  73.381  2.073   1.00 79.91  ? 119 TRP C CB  1 
ATOM   8818  C CG  . TRP C 1 119 ? 39.598  72.912  1.554   1.00 83.21  ? 119 TRP C CG  1 
ATOM   8819  C CD1 . TRP C 1 119 ? 39.371  71.865  0.708   1.00 77.46  ? 119 TRP C CD1 1 
ATOM   8820  C CD2 . TRP C 1 119 ? 38.299  73.487  1.832   1.00 87.56  ? 119 TRP C CD2 1 
ATOM   8821  N NE1 . TRP C 1 119 ? 38.033  71.747  0.441   1.00 81.23  ? 119 TRP C NE1 1 
ATOM   8822  C CE2 . TRP C 1 119 ? 37.347  72.725  1.113   1.00 89.71  ? 119 TRP C CE2 1 
ATOM   8823  C CE3 . TRP C 1 119 ? 37.847  74.562  2.609   1.00 82.53  ? 119 TRP C CE3 1 
ATOM   8824  C CZ2 . TRP C 1 119 ? 35.978  73.007  1.154   1.00 92.25  ? 119 TRP C CZ2 1 
ATOM   8825  C CZ3 . TRP C 1 119 ? 36.496  74.841  2.643   1.00 82.24  ? 119 TRP C CZ3 1 
ATOM   8826  C CH2 . TRP C 1 119 ? 35.572  74.075  1.928   1.00 88.26  ? 119 TRP C CH2 1 
ATOM   8827  N N   . GLY C 1 120 ? 43.996  74.320  1.841   1.00 107.22 ? 120 GLY C N   1 
ATOM   8828  C CA  . GLY C 1 120 ? 45.258  74.895  2.289   1.00 103.13 ? 120 GLY C CA  1 
ATOM   8829  C C   . GLY C 1 120 ? 45.853  75.898  1.294   1.00 96.32  ? 120 GLY C C   1 
ATOM   8830  O O   . GLY C 1 120 ? 46.104  77.049  1.661   1.00 85.96  ? 120 GLY C O   1 
ATOM   8831  N N   . ASP C 1 121 ? 46.053  75.454  0.040   1.00 89.89  ? 121 ASP C N   1 
ATOM   8832  C CA  . ASP C 1 121 ? 46.826  76.179  -0.966  1.00 82.35  ? 121 ASP C CA  1 
ATOM   8833  C C   . ASP C 1 121 ? 46.182  77.523  -1.324  1.00 88.27  ? 121 ASP C C   1 
ATOM   8834  O O   . ASP C 1 121 ? 46.874  78.458  -1.717  1.00 90.07  ? 121 ASP C O   1 
ATOM   8835  C CB  . ASP C 1 121 ? 47.016  75.348  -2.229  1.00 75.30  ? 121 ASP C CB  1 
ATOM   8836  C CG  . ASP C 1 121 ? 47.651  73.975  -2.052  1.00 75.00  ? 121 ASP C CG  1 
ATOM   8837  O OD1 . ASP C 1 121 ? 48.263  73.727  -0.988  1.00 64.99  ? 121 ASP C OD1 1 
ATOM   8838  O OD2 . ASP C 1 121 ? 47.501  73.148  -2.974  1.00 78.50  ? 121 ASP C OD2 1 
ATOM   8839  N N   . ASN C 1 122 ? 44.852  77.623  -1.200  1.00 98.30  ? 122 ASN C N   1 
ATOM   8840  C CA  . ASN C 1 122 ? 44.129  78.822  -1.598  1.00 90.10  ? 122 ASN C CA  1 
ATOM   8841  C C   . ASN C 1 122 ? 44.096  79.844  -0.463  1.00 83.04  ? 122 ASN C C   1 
ATOM   8842  O O   . ASN C 1 122 ? 43.731  80.991  -0.700  1.00 80.98  ? 122 ASN C O   1 
ATOM   8843  C CB  . ASN C 1 122 ? 42.719  78.490  -2.088  1.00 88.34  ? 122 ASN C CB  1 
ATOM   8844  C CG  . ASN C 1 122 ? 42.732  77.794  -3.430  1.00 80.63  ? 122 ASN C CG  1 
ATOM   8845  O OD1 . ASN C 1 122 ? 43.664  77.993  -4.215  1.00 75.51  ? 122 ASN C OD1 1 
ATOM   8846  N ND2 . ASN C 1 122 ? 41.711  77.002  -3.726  1.00 76.28  ? 122 ASN C ND2 1 
ATOM   8847  N N   . ALA C 1 123 ? 44.491  79.436  0.753   1.00 88.68  ? 123 ALA C N   1 
ATOM   8848  C CA  . ALA C 1 123 ? 44.232  80.221  1.954   1.00 90.71  ? 123 ALA C CA  1 
ATOM   8849  C C   . ALA C 1 123 ? 44.967  81.562  1.883   1.00 94.17  ? 123 ALA C C   1 
ATOM   8850  O O   . ALA C 1 123 ? 45.904  81.710  1.100   1.00 101.30 ? 123 ALA C O   1 
ATOM   8851  C CB  . ALA C 1 123 ? 44.612  79.421  3.188   1.00 86.71  ? 123 ALA C CB  1 
ATOM   8852  N N   . VAL C 1 124 ? 44.484  82.543  2.665   1.00 88.36  ? 124 VAL C N   1 
ATOM   8853  C CA  . VAL C 1 124 ? 45.153  83.824  2.859   1.00 87.58  ? 124 VAL C CA  1 
ATOM   8854  C C   . VAL C 1 124 ? 45.187  84.114  4.366   1.00 84.99  ? 124 VAL C C   1 
ATOM   8855  O O   . VAL C 1 124 ? 44.185  84.543  4.943   1.00 86.31  ? 124 VAL C O   1 
ATOM   8856  C CB  . VAL C 1 124 ? 44.464  84.943  2.042   1.00 86.91  ? 124 VAL C CB  1 
ATOM   8857  C CG1 . VAL C 1 124 ? 45.194  86.288  2.130   1.00 81.48  ? 124 VAL C CG1 1 
ATOM   8858  C CG2 . VAL C 1 124 ? 44.276  84.532  0.583   1.00 78.11  ? 124 VAL C CG2 1 
ATOM   8859  N N   . VAL C 1 125 ? 46.345  83.840  4.994   1.00 85.46  ? 125 VAL C N   1 
ATOM   8860  C CA  . VAL C 1 125 ? 46.521  83.934  6.441   1.00 89.01  ? 125 VAL C CA  1 
ATOM   8861  C C   . VAL C 1 125 ? 47.270  85.226  6.786   1.00 90.03  ? 125 VAL C C   1 
ATOM   8862  O O   . VAL C 1 125 ? 48.197  85.626  6.087   1.00 75.12  ? 125 VAL C O   1 
ATOM   8863  C CB  . VAL C 1 125 ? 47.263  82.717  7.031   1.00 83.86  ? 125 VAL C CB  1 
ATOM   8864  C CG1 . VAL C 1 125 ? 47.170  82.722  8.549   1.00 86.99  ? 125 VAL C CG1 1 
ATOM   8865  C CG2 . VAL C 1 125 ? 46.766  81.383  6.479   1.00 80.87  ? 125 VAL C CG2 1 
ATOM   8866  N N   . ALA C 1 126 ? 46.870  85.874  7.886   1.00 102.36 ? 126 ALA C N   1 
ATOM   8867  C CA  . ALA C 1 126 ? 47.446  87.153  8.267   1.00 106.12 ? 126 ALA C CA  1 
ATOM   8868  C C   . ALA C 1 126 ? 48.758  86.930  9.023   1.00 106.16 ? 126 ALA C C   1 
ATOM   8869  O O   . ALA C 1 126 ? 48.980  85.872  9.626   1.00 94.66  ? 126 ALA C O   1 
ATOM   8870  C CB  . ALA C 1 126 ? 46.448  87.966  9.073   1.00 99.49  ? 126 ALA C CB  1 
ATOM   8871  N N   . GLY C 1 127 ? 49.617  87.956  8.974   1.00 100.22 ? 127 GLY C N   1 
ATOM   8872  C CA  . GLY C 1 127 ? 50.949  87.880  9.542   1.00 100.45 ? 127 GLY C CA  1 
ATOM   8873  C C   . GLY C 1 127 ? 51.771  86.858  8.770   1.00 104.09 ? 127 GLY C C   1 
ATOM   8874  O O   . GLY C 1 127 ? 51.449  86.538  7.627   1.00 104.19 ? 127 GLY C O   1 
ATOM   8875  N N   . GLY C 1 128 ? 52.808  86.328  9.419   1.00 94.97  ? 128 GLY C N   1 
ATOM   8876  C CA  . GLY C 1 128 ? 53.683  85.362  8.783   1.00 93.50  ? 128 GLY C CA  1 
ATOM   8877  C C   . GLY C 1 128 ? 53.163  83.934  8.918   1.00 95.80  ? 128 GLY C C   1 
ATOM   8878  O O   . GLY C 1 128 ? 53.771  83.025  8.363   1.00 91.76  ? 128 GLY C O   1 
ATOM   8879  N N   . ARG C 1 129 ? 52.047  83.731  9.640   1.00 105.07 ? 129 ARG C N   1 
ATOM   8880  C CA  . ARG C 1 129 ? 51.633  82.389  10.033  1.00 100.71 ? 129 ARG C CA  1 
ATOM   8881  C C   . ARG C 1 129 ? 51.364  81.519  8.805   1.00 97.03  ? 129 ARG C C   1 
ATOM   8882  O O   . ARG C 1 129 ? 50.693  81.934  7.859   1.00 85.09  ? 129 ARG C O   1 
ATOM   8883  C CB  . ARG C 1 129 ? 50.362  82.332  10.887  1.00 98.87  ? 129 ARG C CB  1 
ATOM   8884  C CG  . ARG C 1 129 ? 50.478  82.709  12.355  1.00 95.13  ? 129 ARG C CG  1 
ATOM   8885  C CD  . ARG C 1 129 ? 50.034  84.136  12.608  1.00 95.61  ? 129 ARG C CD  1 
ATOM   8886  N NE  . ARG C 1 129 ? 50.041  84.415  14.047  1.00 98.19  ? 129 ARG C NE  1 
ATOM   8887  C CZ  . ARG C 1 129 ? 49.973  85.631  14.575  1.00 104.84 ? 129 ARG C CZ  1 
ATOM   8888  N NH1 . ARG C 1 129 ? 49.769  86.677  13.791  1.00 103.96 ? 129 ARG C NH1 1 
ATOM   8889  N NH2 . ARG C 1 129 ? 50.114  85.797  15.880  1.00 102.86 ? 129 ARG C NH2 1 
ATOM   8890  N N   . THR C 1 130 ? 51.906  80.299  8.832   1.00 89.79  ? 130 THR C N   1 
ATOM   8891  C CA  . THR C 1 130 ? 51.546  79.290  7.851   1.00 96.61  ? 130 THR C CA  1 
ATOM   8892  C C   . THR C 1 130 ? 50.918  78.142  8.637   1.00 92.75  ? 130 THR C C   1 
ATOM   8893  O O   . THR C 1 130 ? 51.503  77.677  9.610   1.00 79.44  ? 130 THR C O   1 
ATOM   8894  C CB  . THR C 1 130 ? 52.742  78.856  6.987   1.00 96.62  ? 130 THR C CB  1 
ATOM   8895  O OG1 . THR C 1 130 ? 53.846  78.600  7.852   1.00 87.10  ? 130 THR C OG1 1 
ATOM   8896  C CG2 . THR C 1 130 ? 53.138  79.882  5.930   1.00 84.74  ? 130 THR C CG2 1 
ATOM   8897  N N   . ILE C 1 131 ? 49.697  77.746  8.245   1.00 89.07  ? 131 ILE C N   1 
ATOM   8898  C CA  . ILE C 1 131 ? 48.981  76.670  8.910   1.00 83.71  ? 131 ILE C CA  1 
ATOM   8899  C C   . ILE C 1 131 ? 48.735  75.552  7.902   1.00 76.31  ? 131 ILE C C   1 
ATOM   8900  O O   . ILE C 1 131 ? 48.473  75.811  6.729   1.00 77.24  ? 131 ILE C O   1 
ATOM   8901  C CB  . ILE C 1 131 ? 47.687  77.199  9.564   1.00 86.12  ? 131 ILE C CB  1 
ATOM   8902  C CG1 . ILE C 1 131 ? 48.014  78.205  10.668  1.00 84.91  ? 131 ILE C CG1 1 
ATOM   8903  C CG2 . ILE C 1 131 ? 46.797  76.068  10.090  1.00 84.54  ? 131 ILE C CG2 1 
ATOM   8904  C CD1 . ILE C 1 131 ? 48.163  79.632  10.182  1.00 84.24  ? 131 ILE C CD1 1 
ATOM   8905  N N   . SER C 1 132 ? 48.823  74.305  8.380   1.00 83.75  ? 132 SER C N   1 
ATOM   8906  C CA  . SER C 1 132 ? 48.672  73.141  7.520   1.00 86.86  ? 132 SER C CA  1 
ATOM   8907  C C   . SER C 1 132 ? 47.199  72.725  7.450   1.00 82.43  ? 132 SER C C   1 
ATOM   8908  O O   . SER C 1 132 ? 46.789  71.725  8.040   1.00 65.89  ? 132 SER C O   1 
ATOM   8909  C CB  . SER C 1 132 ? 49.563  72.014  7.972   1.00 77.42  ? 132 SER C CB  1 
ATOM   8910  O OG  . SER C 1 132 ? 49.489  70.956  7.027   1.00 90.81  ? 132 SER C OG  1 
ATOM   8911  N N   . PHE C 1 133 ? 46.416  73.498  6.684   1.00 87.18  ? 133 PHE C N   1 
ATOM   8912  C CA  . PHE C 1 133 ? 44.967  73.341  6.603   1.00 83.23  ? 133 PHE C CA  1 
ATOM   8913  C C   . PHE C 1 133 ? 44.591  71.944  6.108   1.00 71.94  ? 133 PHE C C   1 
ATOM   8914  O O   . PHE C 1 133 ? 43.745  71.290  6.707   1.00 63.79  ? 133 PHE C O   1 
ATOM   8915  C CB  . PHE C 1 133 ? 44.374  74.424  5.700   1.00 76.86  ? 133 PHE C CB  1 
ATOM   8916  C CG  . PHE C 1 133 ? 44.460  75.832  6.276   1.00 78.95  ? 133 PHE C CG  1 
ATOM   8917  C CD1 . PHE C 1 133 ? 43.654  76.213  7.346   1.00 81.03  ? 133 PHE C CD1 1 
ATOM   8918  C CD2 . PHE C 1 133 ? 45.316  76.781  5.726   1.00 79.99  ? 133 PHE C CD2 1 
ATOM   8919  C CE1 . PHE C 1 133 ? 43.719  77.499  7.862   1.00 78.01  ? 133 PHE C CE1 1 
ATOM   8920  C CE2 . PHE C 1 133 ? 45.377  78.066  6.246   1.00 80.20  ? 133 PHE C CE2 1 
ATOM   8921  C CZ  . PHE C 1 133 ? 44.581  78.421  7.314   1.00 81.58  ? 133 PHE C CZ  1 
ATOM   8922  N N   . ALA C 1 134 ? 45.235  71.491  5.027   1.00 72.90  ? 134 ALA C N   1 
ATOM   8923  C CA  . ALA C 1 134 ? 45.027  70.150  4.505   1.00 75.56  ? 134 ALA C CA  1 
ATOM   8924  C C   . ALA C 1 134 ? 45.158  69.095  5.610   1.00 78.35  ? 134 ALA C C   1 
ATOM   8925  O O   . ALA C 1 134 ? 44.269  68.254  5.754   1.00 76.92  ? 134 ALA C O   1 
ATOM   8926  C CB  . ALA C 1 134 ? 45.987  69.894  3.361   1.00 76.93  ? 134 ALA C CB  1 
ATOM   8927  N N   . ASP C 1 135 ? 46.252  69.151  6.394   1.00 87.07  ? 135 ASP C N   1 
ATOM   8928  C CA  . ASP C 1 135 ? 46.506  68.192  7.470   1.00 88.42  ? 135 ASP C CA  1 
ATOM   8929  C C   . ASP C 1 135 ? 45.419  68.261  8.544   1.00 79.24  ? 135 ASP C C   1 
ATOM   8930  O O   . ASP C 1 135 ? 45.006  67.224  9.072   1.00 74.30  ? 135 ASP C O   1 
ATOM   8931  C CB  . ASP C 1 135 ? 47.833  68.417  8.189   1.00 92.15  ? 135 ASP C CB  1 
ATOM   8932  C CG  . ASP C 1 135 ? 49.116  68.006  7.475   1.00 90.57  ? 135 ASP C CG  1 
ATOM   8933  O OD1 . ASP C 1 135 ? 49.088  67.029  6.685   1.00 79.02  ? 135 ASP C OD1 1 
ATOM   8934  O OD2 . ASP C 1 135 ? 50.155  68.630  7.777   1.00 87.32  ? 135 ASP C OD2 1 
ATOM   8935  N N   . ASN C 1 136 ? 45.009  69.492  8.896   1.00 67.18  ? 136 ASN C N   1 
ATOM   8936  C CA  . ASN C 1 136 ? 43.911  69.714  9.826   1.00 68.45  ? 136 ASN C CA  1 
ATOM   8937  C C   . ASN C 1 136 ? 42.709  68.873  9.399   1.00 68.62  ? 136 ASN C C   1 
ATOM   8938  O O   . ASN C 1 136 ? 42.156  68.132  10.210  1.00 71.05  ? 136 ASN C O   1 
ATOM   8939  C CB  . ASN C 1 136 ? 43.519  71.189  9.929   1.00 68.53  ? 136 ASN C CB  1 
ATOM   8940  C CG  . ASN C 1 136 ? 44.560  72.045  10.617  1.00 68.29  ? 136 ASN C CG  1 
ATOM   8941  O OD1 . ASN C 1 136 ? 45.460  71.521  11.285  1.00 61.25  ? 136 ASN C OD1 1 
ATOM   8942  N ND2 . ASN C 1 136 ? 44.449  73.362  10.477  1.00 73.07  ? 136 ASN C ND2 1 
ATOM   8943  N N   . ILE C 1 137 ? 42.347  68.972  8.109   1.00 69.82  ? 137 ILE C N   1 
ATOM   8944  C CA  . ILE C 1 137 ? 41.192  68.274  7.561   1.00 69.50  ? 137 ILE C CA  1 
ATOM   8945  C C   . ILE C 1 137 ? 41.349  66.771  7.769   1.00 62.80  ? 137 ILE C C   1 
ATOM   8946  O O   . ILE C 1 137 ? 40.397  66.109  8.167   1.00 69.80  ? 137 ILE C O   1 
ATOM   8947  C CB  . ILE C 1 137 ? 40.962  68.631  6.079   1.00 71.32  ? 137 ILE C CB  1 
ATOM   8948  C CG1 . ILE C 1 137 ? 40.524  70.096  5.930   1.00 69.23  ? 137 ILE C CG1 1 
ATOM   8949  C CG2 . ILE C 1 137 ? 39.968  67.664  5.420   1.00 61.03  ? 137 ILE C CG2 1 
ATOM   8950  C CD1 . ILE C 1 137 ? 40.715  70.669  4.534   1.00 71.47  ? 137 ILE C CD1 1 
ATOM   8951  N N   . ARG C 1 138 ? 42.547  66.236  7.535   1.00 64.72  ? 138 ARG C N   1 
ATOM   8952  C CA  . ARG C 1 138 ? 42.745  64.797  7.653   1.00 74.89  ? 138 ARG C CA  1 
ATOM   8953  C C   . ARG C 1 138 ? 42.595  64.352  9.109   1.00 73.87  ? 138 ARG C C   1 
ATOM   8954  O O   . ARG C 1 138 ? 42.019  63.294  9.356   1.00 71.08  ? 138 ARG C O   1 
ATOM   8955  C CB  . ARG C 1 138 ? 44.056  64.323  7.011   1.00 82.71  ? 138 ARG C CB  1 
ATOM   8956  C CG  . ARG C 1 138 ? 43.941  64.159  5.500   1.00 84.69  ? 138 ARG C CG  1 
ATOM   8957  C CD  . ARG C 1 138 ? 45.247  63.742  4.818   1.00 94.65  ? 138 ARG C CD  1 
ATOM   8958  N NE  . ARG C 1 138 ? 46.262  64.805  4.804   1.00 94.59  ? 138 ARG C NE  1 
ATOM   8959  C CZ  . ARG C 1 138 ? 46.525  65.641  3.795   1.00 99.15  ? 138 ARG C CZ  1 
ATOM   8960  N NH1 . ARG C 1 138 ? 45.832  65.594  2.669   1.00 100.15 ? 138 ARG C NH1 1 
ATOM   8961  N NH2 . ARG C 1 138 ? 47.470  66.559  3.926   1.00 100.92 ? 138 ARG C NH2 1 
ATOM   8962  N N   . SER C 1 139 ? 43.073  65.163  10.068  1.00 79.26  ? 139 SER C N   1 
ATOM   8963  C CA  . SER C 1 139 ? 43.051  64.775  11.477  1.00 78.33  ? 139 SER C CA  1 
ATOM   8964  C C   . SER C 1 139 ? 41.660  64.989  12.080  1.00 72.00  ? 139 SER C C   1 
ATOM   8965  O O   . SER C 1 139 ? 41.218  64.182  12.900  1.00 66.49  ? 139 SER C O   1 
ATOM   8966  C CB  . SER C 1 139 ? 44.131  65.484  12.288  1.00 79.41  ? 139 SER C CB  1 
ATOM   8967  O OG  . SER C 1 139 ? 43.911  66.888  12.347  1.00 75.63  ? 139 SER C OG  1 
ATOM   8968  N N   . GLN C 1 140 ? 40.987  66.084  11.684  1.00 70.75  ? 140 GLN C N   1 
ATOM   8969  C CA  . GLN C 1 140 ? 39.588  66.316  12.034  1.00 74.02  ? 140 GLN C CA  1 
ATOM   8970  C C   . GLN C 1 140 ? 38.752  65.096  11.625  1.00 67.87  ? 140 GLN C C   1 
ATOM   8971  O O   . GLN C 1 140 ? 37.981  64.554  12.423  1.00 62.40  ? 140 GLN C O   1 
ATOM   8972  C CB  . GLN C 1 140 ? 39.044  67.586  11.365  1.00 72.52  ? 140 GLN C CB  1 
ATOM   8973  C CG  . GLN C 1 140 ? 39.580  68.913  11.907  1.00 65.32  ? 140 GLN C CG  1 
ATOM   8974  C CD  . GLN C 1 140 ? 39.348  70.076  10.957  1.00 78.38  ? 140 GLN C CD  1 
ATOM   8975  O OE1 . GLN C 1 140 ? 38.701  69.942  9.907   1.00 88.34  ? 140 GLN C OE1 1 
ATOM   8976  N NE2 . GLN C 1 140 ? 39.878  71.246  11.295  1.00 71.54  ? 140 GLN C NE2 1 
ATOM   8977  N N   . TRP C 1 141 ? 38.952  64.643  10.380  1.00 62.54  ? 141 TRP C N   1 
ATOM   8978  C CA  . TRP C 1 141 ? 38.217  63.522  9.819   1.00 59.33  ? 141 TRP C CA  1 
ATOM   8979  C C   . TRP C 1 141 ? 38.493  62.246  10.617  1.00 63.86  ? 141 TRP C C   1 
ATOM   8980  O O   . TRP C 1 141 ? 37.563  61.490  10.894  1.00 60.54  ? 141 TRP C O   1 
ATOM   8981  C CB  . TRP C 1 141 ? 38.567  63.365  8.328   1.00 60.12  ? 141 TRP C CB  1 
ATOM   8982  C CG  . TRP C 1 141 ? 37.883  62.203  7.669   1.00 52.06  ? 141 TRP C CG  1 
ATOM   8983  C CD1 . TRP C 1 141 ? 38.445  61.000  7.366   1.00 59.83  ? 141 TRP C CD1 1 
ATOM   8984  C CD2 . TRP C 1 141 ? 36.489  62.097  7.324   1.00 56.32  ? 141 TRP C CD2 1 
ATOM   8985  N NE1 . TRP C 1 141 ? 37.505  60.158  6.835   1.00 59.07  ? 141 TRP C NE1 1 
ATOM   8986  C CE2 . TRP C 1 141 ? 36.294  60.795  6.806   1.00 62.03  ? 141 TRP C CE2 1 
ATOM   8987  C CE3 . TRP C 1 141 ? 35.387  62.959  7.412   1.00 63.90  ? 141 TRP C CE3 1 
ATOM   8988  C CZ2 . TRP C 1 141 ? 35.047  60.345  6.365   1.00 64.79  ? 141 TRP C CZ2 1 
ATOM   8989  C CZ3 . TRP C 1 141 ? 34.149  62.509  6.988   1.00 67.92  ? 141 TRP C CZ3 1 
ATOM   8990  C CH2 . TRP C 1 141 ? 33.983  61.216  6.477   1.00 66.06  ? 141 TRP C CH2 1 
ATOM   8991  N N   . GLN C 1 142 ? 39.762  62.019  11.005  1.00 70.14  ? 142 GLN C N   1 
ATOM   8992  C CA  . GLN C 1 142 ? 40.134  60.844  11.788  1.00 72.02  ? 142 GLN C CA  1 
ATOM   8993  C C   . GLN C 1 142 ? 39.490  60.918  13.176  1.00 63.32  ? 142 GLN C C   1 
ATOM   8994  O O   . GLN C 1 142 ? 39.050  59.895  13.708  1.00 62.38  ? 142 GLN C O   1 
ATOM   8995  C CB  . GLN C 1 142 ? 41.655  60.647  11.872  1.00 85.76  ? 142 GLN C CB  1 
ATOM   8996  C CG  . GLN C 1 142 ? 42.102  59.279  12.402  1.00 91.75  ? 142 GLN C CG  1 
ATOM   8997  C CD  . GLN C 1 142 ? 42.152  59.162  13.918  1.00 95.25  ? 142 GLN C CD  1 
ATOM   8998  O OE1 . GLN C 1 142 ? 42.071  60.153  14.661  1.00 80.95  ? 142 GLN C OE1 1 
ATOM   8999  N NE2 . GLN C 1 142 ? 42.305  57.934  14.401  1.00 88.44  ? 142 GLN C NE2 1 
ATOM   9000  N N   . ARG C 1 143 ? 39.412  62.129  13.747  1.00 63.49  ? 143 ARG C N   1 
ATOM   9001  C CA  . ARG C 1 143 ? 38.828  62.321  15.070  1.00 67.95  ? 143 ARG C CA  1 
ATOM   9002  C C   . ARG C 1 143 ? 37.318  62.044  15.041  1.00 69.72  ? 143 ARG C C   1 
ATOM   9003  O O   . ARG C 1 143 ? 36.814  61.203  15.798  1.00 64.20  ? 143 ARG C O   1 
ATOM   9004  C CB  . ARG C 1 143 ? 39.154  63.721  15.613  1.00 65.77  ? 143 ARG C CB  1 
ATOM   9005  C CG  . ARG C 1 143 ? 38.687  64.014  17.036  1.00 63.56  ? 143 ARG C CG  1 
ATOM   9006  C CD  . ARG C 1 143 ? 39.127  65.401  17.566  1.00 62.84  ? 143 ARG C CD  1 
ATOM   9007  N NE  . ARG C 1 143 ? 38.610  66.526  16.779  1.00 64.74  ? 143 ARG C NE  1 
ATOM   9008  C CZ  . ARG C 1 143 ? 37.317  66.852  16.667  1.00 66.95  ? 143 ARG C CZ  1 
ATOM   9009  N NH1 . ARG C 1 143 ? 36.396  66.224  17.375  1.00 59.28  ? 143 ARG C NH1 1 
ATOM   9010  N NH2 . ARG C 1 143 ? 36.947  67.831  15.861  1.00 67.97  ? 143 ARG C NH2 1 
ATOM   9011  N N   . VAL C 1 144 ? 36.587  62.746  14.164  1.00 65.01  ? 144 VAL C N   1 
ATOM   9012  C CA  . VAL C 1 144 ? 35.133  62.698  14.212  1.00 58.68  ? 144 VAL C CA  1 
ATOM   9013  C C   . VAL C 1 144 ? 34.635  61.309  13.811  1.00 58.35  ? 144 VAL C C   1 
ATOM   9014  O O   . VAL C 1 144 ? 33.586  60.893  14.299  1.00 51.96  ? 144 VAL C O   1 
ATOM   9015  C CB  . VAL C 1 144 ? 34.459  63.792  13.366  1.00 63.88  ? 144 VAL C CB  1 
ATOM   9016  C CG1 . VAL C 1 144 ? 34.991  65.179  13.725  1.00 62.34  ? 144 VAL C CG1 1 
ATOM   9017  C CG2 . VAL C 1 144 ? 34.577  63.514  11.867  1.00 65.79  ? 144 VAL C CG2 1 
ATOM   9018  N N   . THR C 1 145 ? 35.384  60.587  12.954  1.00 59.33  ? 145 THR C N   1 
ATOM   9019  C CA  . THR C 1 145 ? 34.937  59.286  12.469  1.00 66.39  ? 145 THR C CA  1 
ATOM   9020  C C   . THR C 1 145 ? 35.109  58.219  13.551  1.00 65.65  ? 145 THR C C   1 
ATOM   9021  O O   . THR C 1 145 ? 34.224  57.383  13.722  1.00 64.44  ? 145 THR C O   1 
ATOM   9022  C CB  . THR C 1 145 ? 35.636  58.873  11.168  1.00 68.86  ? 145 THR C CB  1 
ATOM   9023  O OG1 . THR C 1 145 ? 37.032  59.076  11.330  1.00 64.33  ? 145 THR C OG1 1 
ATOM   9024  C CG2 . THR C 1 145 ? 35.203  59.697  9.969   1.00 74.85  ? 145 THR C CG2 1 
ATOM   9025  N N   . THR C 1 146 ? 36.244  58.223  14.265  1.00 67.49  ? 146 THR C N   1 
ATOM   9026  C CA  . THR C 1 146 ? 36.493  57.173  15.245  1.00 70.78  ? 146 THR C CA  1 
ATOM   9027  C C   . THR C 1 146 ? 35.800  57.531  16.564  1.00 60.64  ? 146 THR C C   1 
ATOM   9028  O O   . THR C 1 146 ? 35.334  56.626  17.251  1.00 63.98  ? 146 THR C O   1 
ATOM   9029  C CB  . THR C 1 146 ? 37.985  56.830  15.410  1.00 76.40  ? 146 THR C CB  1 
ATOM   9030  O OG1 . THR C 1 146 ? 38.733  57.933  15.896  1.00 75.58  ? 146 THR C OG1 1 
ATOM   9031  C CG2 . THR C 1 146 ? 38.673  56.452  14.109  1.00 74.09  ? 146 THR C CG2 1 
ATOM   9032  N N   . ASP C 1 147 ? 35.652  58.827  16.898  1.00 60.44  ? 147 ASP C N   1 
ATOM   9033  C CA  . ASP C 1 147 ? 34.889  59.208  18.093  1.00 61.47  ? 147 ASP C CA  1 
ATOM   9034  C C   . ASP C 1 147 ? 33.385  59.297  17.812  1.00 62.35  ? 147 ASP C C   1 
ATOM   9035  O O   . ASP C 1 147 ? 32.609  59.401  18.758  1.00 62.62  ? 147 ASP C O   1 
ATOM   9036  C CB  . ASP C 1 147 ? 35.375  60.498  18.738  1.00 62.60  ? 147 ASP C CB  1 
ATOM   9037  C CG  . ASP C 1 147 ? 36.767  60.442  19.352  1.00 63.41  ? 147 ASP C CG  1 
ATOM   9038  O OD1 . ASP C 1 147 ? 37.226  59.309  19.631  1.00 61.93  ? 147 ASP C OD1 1 
ATOM   9039  O OD2 . ASP C 1 147 ? 37.395  61.525  19.503  1.00 56.89  ? 147 ASP C OD2 1 
ATOM   9040  N N   . ASP C 1 148 ? 32.981  59.249  16.528  1.00 66.83  ? 148 ASP C N   1 
ATOM   9041  C CA  . ASP C 1 148 ? 31.582  59.284  16.100  1.00 65.94  ? 148 ASP C CA  1 
ATOM   9042  C C   . ASP C 1 148 ? 30.889  60.566  16.580  1.00 60.43  ? 148 ASP C C   1 
ATOM   9043  O O   . ASP C 1 148 ? 29.861  60.504  17.259  1.00 52.32  ? 148 ASP C O   1 
ATOM   9044  C CB  . ASP C 1 148 ? 30.826  58.031  16.526  1.00 64.51  ? 148 ASP C CB  1 
ATOM   9045  C CG  . ASP C 1 148 ? 29.598  57.688  15.695  1.00 61.44  ? 148 ASP C CG  1 
ATOM   9046  O OD1 . ASP C 1 148 ? 29.423  58.302  14.626  1.00 63.08  ? 148 ASP C OD1 1 
ATOM   9047  O OD2 . ASP C 1 148 ? 28.831  56.803  16.120  1.00 62.28  ? 148 ASP C OD2 1 
ATOM   9048  N N   . VAL C 1 149 ? 31.463  61.721  16.206  1.00 53.53  ? 149 VAL C N   1 
ATOM   9049  C CA  . VAL C 1 149 ? 30.936  63.022  16.592  1.00 56.26  ? 149 VAL C CA  1 
ATOM   9050  C C   . VAL C 1 149 ? 29.757  63.403  15.695  1.00 60.28  ? 149 VAL C C   1 
ATOM   9051  O O   . VAL C 1 149 ? 29.728  63.071  14.508  1.00 59.54  ? 149 VAL C O   1 
ATOM   9052  C CB  . VAL C 1 149 ? 32.028  64.103  16.515  1.00 53.34  ? 149 VAL C CB  1 
ATOM   9053  C CG1 . VAL C 1 149 ? 31.488  65.473  16.904  1.00 57.85  ? 149 VAL C CG1 1 
ATOM   9054  C CG2 . VAL C 1 149 ? 33.228  63.757  17.379  1.00 56.92  ? 149 VAL C CG2 1 
ATOM   9055  N N   . ALA C 1 150 ? 28.812  64.160  16.266  1.00 57.04  ? 150 ALA C N   1 
ATOM   9056  C CA  . ALA C 1 150 ? 27.702  64.704  15.500  1.00 57.28  ? 150 ALA C CA  1 
ATOM   9057  C C   . ALA C 1 150 ? 28.005  66.157  15.128  1.00 53.20  ? 150 ALA C C   1 
ATOM   9058  O O   . ALA C 1 150 ? 28.383  66.962  15.967  1.00 53.97  ? 150 ALA C O   1 
ATOM   9059  C CB  . ALA C 1 150 ? 26.407  64.551  16.275  1.00 53.03  ? 150 ALA C CB  1 
ATOM   9060  N N   . LEU C 1 151 ? 27.834  66.473  13.845  1.00 52.66  ? 151 LEU C N   1 
ATOM   9061  C CA  . LEU C 1 151 ? 28.258  67.739  13.274  1.00 55.15  ? 151 LEU C CA  1 
ATOM   9062  C C   . LEU C 1 151 ? 27.111  68.332  12.451  1.00 56.53  ? 151 LEU C C   1 
ATOM   9063  O O   . LEU C 1 151 ? 26.426  67.611  11.722  1.00 48.28  ? 151 LEU C O   1 
ATOM   9064  C CB  . LEU C 1 151 ? 29.496  67.437  12.427  1.00 61.61  ? 151 LEU C CB  1 
ATOM   9065  C CG  . LEU C 1 151 ? 30.753  66.995  13.196  1.00 65.36  ? 151 LEU C CG  1 
ATOM   9066  C CD1 . LEU C 1 151 ? 31.518  65.894  12.494  1.00 61.26  ? 151 LEU C CD1 1 
ATOM   9067  C CD2 . LEU C 1 151 ? 31.690  68.166  13.420  1.00 70.55  ? 151 LEU C CD2 1 
ATOM   9068  N N   . SER C 1 152 ? 26.872  69.643  12.608  1.00 53.89  ? 152 SER C N   1 
ATOM   9069  C CA  . SER C 1 152 ? 25.917  70.341  11.766  1.00 58.57  ? 152 SER C CA  1 
ATOM   9070  C C   . SER C 1 152 ? 26.634  71.407  10.959  1.00 55.55  ? 152 SER C C   1 
ATOM   9071  O O   . SER C 1 152 ? 27.425  72.165  11.507  1.00 58.03  ? 152 SER C O   1 
ATOM   9072  C CB  . SER C 1 152 ? 24.788  70.957  12.561  1.00 63.82  ? 152 SER C CB  1 
ATOM   9073  O OG  . SER C 1 152 ? 23.747  71.415  11.703  1.00 54.48  ? 152 SER C OG  1 
ATOM   9074  N N   . PRO C 1 153 ? 26.351  71.513  9.647   1.00 52.96  ? 153 PRO C N   1 
ATOM   9075  C CA  . PRO C 1 153 ? 26.870  72.626  8.856   1.00 54.19  ? 153 PRO C CA  1 
ATOM   9076  C C   . PRO C 1 153 ? 26.104  73.922  9.116   1.00 52.32  ? 153 PRO C C   1 
ATOM   9077  O O   . PRO C 1 153 ? 24.880  73.929  9.230   1.00 53.60  ? 153 PRO C O   1 
ATOM   9078  C CB  . PRO C 1 153 ? 26.670  72.099  7.413   1.00 53.45  ? 153 PRO C CB  1 
ATOM   9079  C CG  . PRO C 1 153 ? 25.393  71.300  7.500   1.00 48.93  ? 153 PRO C CG  1 
ATOM   9080  C CD  . PRO C 1 153 ? 25.482  70.608  8.868   1.00 51.63  ? 153 PRO C CD  1 
ATOM   9081  N N   . MET C 1 154 ? 26.831  75.032  9.209   1.00 55.18  ? 154 MET C N   1 
ATOM   9082  C CA  . MET C 1 154 ? 26.213  76.346  9.173   1.00 56.23  ? 154 MET C CA  1 
ATOM   9083  C C   . MET C 1 154 ? 26.948  77.154  8.111   1.00 59.45  ? 154 MET C C   1 
ATOM   9084  O O   . MET C 1 154 ? 28.113  77.486  8.332   1.00 56.54  ? 154 MET C O   1 
ATOM   9085  C CB  . MET C 1 154 ? 26.310  77.048  10.532  1.00 56.32  ? 154 MET C CB  1 
ATOM   9086  C CG  . MET C 1 154 ? 25.507  76.393  11.657  1.00 62.27  ? 154 MET C CG  1 
ATOM   9087  S SD  . MET C 1 154 ? 25.123  77.496  13.041  1.00 56.07  ? 154 MET C SD  1 
ATOM   9088  C CE  . MET C 1 154 ? 23.883  78.527  12.243  1.00 56.82  ? 154 MET C CE  1 
ATOM   9089  N N   . PHE C 1 155 ? 26.289  77.425  6.966   1.00 57.41  ? 155 PHE C N   1 
ATOM   9090  C CA  . PHE C 1 155 ? 26.953  78.060  5.828   1.00 59.85  ? 155 PHE C CA  1 
ATOM   9091  C C   . PHE C 1 155 ? 26.250  79.343  5.367   1.00 58.63  ? 155 PHE C C   1 
ATOM   9092  O O   . PHE C 1 155 ? 26.883  80.173  4.716   1.00 64.57  ? 155 PHE C O   1 
ATOM   9093  C CB  . PHE C 1 155 ? 27.091  77.104  4.632   1.00 59.57  ? 155 PHE C CB  1 
ATOM   9094  C CG  . PHE C 1 155 ? 28.305  76.180  4.607   1.00 56.73  ? 155 PHE C CG  1 
ATOM   9095  C CD1 . PHE C 1 155 ? 28.624  75.364  5.692   1.00 62.67  ? 155 PHE C CD1 1 
ATOM   9096  C CD2 . PHE C 1 155 ? 29.148  76.146  3.496   1.00 62.01  ? 155 PHE C CD2 1 
ATOM   9097  C CE1 . PHE C 1 155 ? 29.750  74.540  5.660   1.00 71.03  ? 155 PHE C CE1 1 
ATOM   9098  C CE2 . PHE C 1 155 ? 30.271  75.320  3.464   1.00 65.66  ? 155 PHE C CE2 1 
ATOM   9099  C CZ  . PHE C 1 155 ? 30.574  74.519  4.547   1.00 68.86  ? 155 PHE C CZ  1 
ATOM   9100  N N   . VAL C 1 156 ? 24.955  79.522  5.654   1.00 54.55  ? 156 VAL C N   1 
ATOM   9101  C CA  . VAL C 1 156 ? 24.242  80.665  5.089   1.00 64.82  ? 156 VAL C CA  1 
ATOM   9102  C C   . VAL C 1 156 ? 24.460  81.903  5.977   1.00 60.57  ? 156 VAL C C   1 
ATOM   9103  O O   . VAL C 1 156 ? 24.588  81.795  7.201   1.00 53.70  ? 156 VAL C O   1 
ATOM   9104  C CB  . VAL C 1 156 ? 22.746  80.398  4.783   1.00 63.30  ? 156 VAL C CB  1 
ATOM   9105  C CG1 . VAL C 1 156 ? 22.551  79.078  4.048   1.00 60.19  ? 156 VAL C CG1 1 
ATOM   9106  C CG2 . VAL C 1 156 ? 21.863  80.416  6.018   1.00 70.23  ? 156 VAL C CG2 1 
ATOM   9107  N N   . ASP C 1 157 ? 24.492  83.080  5.323   1.00 63.30  ? 157 ASP C N   1 
ATOM   9108  C CA  . ASP C 1 157 ? 24.875  84.353  5.926   1.00 65.24  ? 157 ASP C CA  1 
ATOM   9109  C C   . ASP C 1 157 ? 23.705  85.337  5.850   1.00 67.85  ? 157 ASP C C   1 
ATOM   9110  O O   . ASP C 1 157 ? 22.858  85.244  4.962   1.00 68.75  ? 157 ASP C O   1 
ATOM   9111  C CB  . ASP C 1 157 ? 26.173  84.881  5.317   1.00 61.92  ? 157 ASP C CB  1 
ATOM   9112  C CG  . ASP C 1 157 ? 27.442  84.137  5.733   1.00 68.81  ? 157 ASP C CG  1 
ATOM   9113  O OD1 . ASP C 1 157 ? 27.695  84.007  6.965   1.00 64.34  ? 157 ASP C OD1 1 
ATOM   9114  O OD2 . ASP C 1 157 ? 28.183  83.675  4.834   1.00 68.89  ? 157 ASP C OD2 1 
ATOM   9115  N N   . VAL C 1 158 ? 23.700  86.310  6.771   1.00 73.14  ? 158 VAL C N   1 
ATOM   9116  C CA  . VAL C 1 158 ? 22.517  87.116  7.057   1.00 87.84  ? 158 VAL C CA  1 
ATOM   9117  C C   . VAL C 1 158 ? 22.173  88.032  5.861   1.00 79.99  ? 158 VAL C C   1 
ATOM   9118  O O   . VAL C 1 158 ? 23.089  88.708  5.370   1.00 77.14  ? 158 VAL C O   1 
ATOM   9119  C CB  . VAL C 1 158 ? 22.611  87.913  8.383   1.00 82.76  ? 158 VAL C CB  1 
ATOM   9120  C CG1 . VAL C 1 158 ? 22.253  87.048  9.589   1.00 77.86  ? 158 VAL C CG1 1 
ATOM   9121  C CG2 . VAL C 1 158 ? 23.961  88.586  8.606   1.00 78.56  ? 158 VAL C CG2 1 
ATOM   9122  N N   . GLU C 1 170 ? 32.078  96.980  10.210  1.00 85.61  ? 170 GLU C N   1 
ATOM   9123  C CA  . GLU C 1 170 ? 31.884  95.557  10.604  1.00 89.33  ? 170 GLU C CA  1 
ATOM   9124  C C   . GLU C 1 170 ? 30.452  95.132  10.252  1.00 88.40  ? 170 GLU C C   1 
ATOM   9125  O O   . GLU C 1 170 ? 29.495  95.760  10.701  1.00 84.50  ? 170 GLU C O   1 
ATOM   9126  C CB  . GLU C 1 170 ? 32.203  95.414  12.100  1.00 92.11  ? 170 GLU C CB  1 
ATOM   9127  C CG  . GLU C 1 170 ? 32.448  93.977  12.572  1.00 90.35  ? 170 GLU C CG  1 
ATOM   9128  C CD  . GLU C 1 170 ? 32.430  93.749  14.082  1.00 85.75  ? 170 GLU C CD  1 
ATOM   9129  O OE1 . GLU C 1 170 ? 32.513  94.744  14.829  1.00 90.94  ? 170 GLU C OE1 1 
ATOM   9130  O OE2 . GLU C 1 170 ? 32.298  92.587  14.533  1.00 74.08  ? 170 GLU C OE2 1 
ATOM   9131  N N   . THR C 1 171 ? 30.309  94.078  9.433   1.00 83.87  ? 171 THR C N   1 
ATOM   9132  C CA  . THR C 1 171 ? 29.015  93.470  9.131   1.00 82.59  ? 171 THR C CA  1 
ATOM   9133  C C   . THR C 1 171 ? 28.532  92.689  10.354  1.00 75.27  ? 171 THR C C   1 
ATOM   9134  O O   . THR C 1 171 ? 29.354  92.278  11.166  1.00 66.75  ? 171 THR C O   1 
ATOM   9135  C CB  . THR C 1 171 ? 29.165  92.549  7.918   1.00 81.58  ? 171 THR C CB  1 
ATOM   9136  O OG1 . THR C 1 171 ? 29.761  93.383  6.936   1.00 93.55  ? 171 THR C OG1 1 
ATOM   9137  C CG2 . THR C 1 171 ? 27.855  92.061  7.325   1.00 85.07  ? 171 THR C CG2 1 
ATOM   9138  N N   . PRO C 1 172 ? 27.206  92.461  10.546  1.00 72.23  ? 172 PRO C N   1 
ATOM   9139  C CA  . PRO C 1 172 ? 26.727  91.463  11.514  1.00 64.91  ? 172 PRO C CA  1 
ATOM   9140  C C   . PRO C 1 172 ? 27.147  90.028  11.182  1.00 60.17  ? 172 PRO C C   1 
ATOM   9141  O O   . PRO C 1 172 ? 27.175  89.168  12.052  1.00 59.80  ? 172 PRO C O   1 
ATOM   9142  C CB  . PRO C 1 172 ? 25.186  91.642  11.495  1.00 65.42  ? 172 PRO C CB  1 
ATOM   9143  C CG  . PRO C 1 172 ? 24.974  93.031  10.922  1.00 69.20  ? 172 PRO C CG  1 
ATOM   9144  C CD  . PRO C 1 172 ? 26.100  93.203  9.911   1.00 69.30  ? 172 PRO C CD  1 
ATOM   9145  N N   . MET C 1 173 ? 27.433  89.782  9.902   1.00 66.03  ? 173 MET C N   1 
ATOM   9146  C CA  . MET C 1 173 ? 28.007  88.543  9.400   1.00 71.85  ? 173 MET C CA  1 
ATOM   9147  C C   . MET C 1 173 ? 29.237  88.136  10.217  1.00 73.39  ? 173 MET C C   1 
ATOM   9148  O O   . MET C 1 173 ? 29.990  88.983  10.697  1.00 69.92  ? 173 MET C O   1 
ATOM   9149  C CB  . MET C 1 173 ? 28.381  88.739  7.923   1.00 80.97  ? 173 MET C CB  1 
ATOM   9150  C CG  . MET C 1 173 ? 29.071  87.559  7.260   1.00 84.43  ? 173 MET C CG  1 
ATOM   9151  S SD  . MET C 1 173 ? 29.410  87.873  5.517   1.00 90.96  ? 173 MET C SD  1 
ATOM   9152  C CE  . MET C 1 173 ? 30.352  86.394  5.108   1.00 93.11  ? 173 MET C CE  1 
ATOM   9153  N N   . LEU C 1 174 ? 29.430  86.818  10.356  1.00 68.92  ? 174 LEU C N   1 
ATOM   9154  C CA  . LEU C 1 174 ? 30.567  86.261  11.068  1.00 65.70  ? 174 LEU C CA  1 
ATOM   9155  C C   . LEU C 1 174 ? 31.850  86.653  10.338  1.00 74.38  ? 174 LEU C C   1 
ATOM   9156  O O   . LEU C 1 174 ? 31.960  86.459  9.122   1.00 66.69  ? 174 LEU C O   1 
ATOM   9157  C CB  . LEU C 1 174 ? 30.425  84.741  11.150  1.00 66.08  ? 174 LEU C CB  1 
ATOM   9158  C CG  . LEU C 1 174 ? 31.490  84.016  11.980  1.00 64.64  ? 174 LEU C CG  1 
ATOM   9159  C CD1 . LEU C 1 174 ? 31.254  84.259  13.470  1.00 63.54  ? 174 LEU C CD1 1 
ATOM   9160  C CD2 . LEU C 1 174 ? 31.524  82.533  11.677  1.00 63.76  ? 174 LEU C CD2 1 
ATOM   9161  N N   . SER C 1 175 ? 32.817  87.198  11.096  1.00 73.29  ? 175 SER C N   1 
ATOM   9162  C CA  . SER C 1 175 ? 34.111  87.581  10.546  1.00 62.14  ? 175 SER C CA  1 
ATOM   9163  C C   . SER C 1 175 ? 35.214  87.433  11.590  1.00 65.28  ? 175 SER C C   1 
ATOM   9164  O O   . SER C 1 175 ? 34.961  87.421  12.791  1.00 66.69  ? 175 SER C O   1 
ATOM   9165  C CB  . SER C 1 175 ? 34.095  88.978  9.951   1.00 61.86  ? 175 SER C CB  1 
ATOM   9166  O OG  . SER C 1 175 ? 33.724  89.959  10.908  1.00 57.02  ? 175 SER C OG  1 
ATOM   9167  N N   . ILE C 1 176 ? 36.443  87.294  11.085  1.00 71.24  ? 176 ILE C N   1 
ATOM   9168  C CA  . ILE C 1 176 ? 37.644  87.202  11.894  1.00 71.54  ? 176 ILE C CA  1 
ATOM   9169  C C   . ILE C 1 176 ? 37.949  88.596  12.437  1.00 67.21  ? 176 ILE C C   1 
ATOM   9170  O O   . ILE C 1 176 ? 37.963  89.554  11.671  1.00 65.41  ? 176 ILE C O   1 
ATOM   9171  C CB  . ILE C 1 176 ? 38.808  86.669  11.037  1.00 80.35  ? 176 ILE C CB  1 
ATOM   9172  C CG1 . ILE C 1 176 ? 38.449  85.345  10.338  1.00 80.05  ? 176 ILE C CG1 1 
ATOM   9173  C CG2 . ILE C 1 176 ? 40.086  86.557  11.873  1.00 80.70  ? 176 ILE C CG2 1 
ATOM   9174  C CD1 . ILE C 1 176 ? 39.422  84.912  9.254   1.00 76.89  ? 176 ILE C CD1 1 
ATOM   9175  N N   . VAL C 1 177 ? 38.181  88.700  13.752  1.00 71.01  ? 177 VAL C N   1 
ATOM   9176  C CA  . VAL C 1 177 ? 38.466  89.978  14.397  1.00 74.53  ? 177 VAL C CA  1 
ATOM   9177  C C   . VAL C 1 177 ? 39.854  89.959  15.041  1.00 71.45  ? 177 VAL C C   1 
ATOM   9178  O O   . VAL C 1 177 ? 40.320  91.011  15.470  1.00 63.70  ? 177 VAL C O   1 
ATOM   9179  C CB  . VAL C 1 177 ? 37.398  90.373  15.439  1.00 75.12  ? 177 VAL C CB  1 
ATOM   9180  C CG1 . VAL C 1 177 ? 36.034  90.625  14.789  1.00 74.00  ? 177 VAL C CG1 1 
ATOM   9181  C CG2 . VAL C 1 177 ? 37.290  89.359  16.578  1.00 68.65  ? 177 VAL C CG2 1 
ATOM   9182  N N   . GLU C 1 178 ? 40.470  88.770  15.139  1.00 66.30  ? 178 GLU C N   1 
ATOM   9183  C CA  . GLU C 1 178 ? 41.843  88.600  15.598  1.00 73.18  ? 178 GLU C CA  1 
ATOM   9184  C C   . GLU C 1 178 ? 42.399  87.291  15.030  1.00 71.16  ? 178 GLU C C   1 
ATOM   9185  O O   . GLU C 1 178 ? 41.679  86.294  14.938  1.00 66.98  ? 178 GLU C O   1 
ATOM   9186  C CB  . GLU C 1 178 ? 41.939  88.610  17.129  1.00 76.12  ? 178 GLU C CB  1 
ATOM   9187  C CG  . GLU C 1 178 ? 43.308  88.228  17.706  1.00 77.80  ? 178 GLU C CG  1 
ATOM   9188  C CD  . GLU C 1 178 ? 43.385  88.158  19.235  1.00 78.41  ? 178 GLU C CD  1 
ATOM   9189  O OE1 . GLU C 1 178 ? 42.589  88.820  19.938  1.00 75.49  ? 178 GLU C OE1 1 
ATOM   9190  O OE2 . GLU C 1 178 ? 44.228  87.393  19.745  1.00 75.66  ? 178 GLU C OE2 1 
ATOM   9191  N N   . GLN C 1 179 ? 43.683  87.325  14.639  1.00 73.11  ? 179 GLN C N   1 
ATOM   9192  C CA  . GLN C 1 179 ? 44.480  86.132  14.392  1.00 78.45  ? 179 GLN C CA  1 
ATOM   9193  C C   . GLN C 1 179 ? 45.713  86.177  15.296  1.00 75.62  ? 179 GLN C C   1 
ATOM   9194  O O   . GLN C 1 179 ? 46.435  87.166  15.303  1.00 75.07  ? 179 GLN C O   1 
ATOM   9195  C CB  . GLN C 1 179 ? 44.874  86.041  12.917  1.00 81.14  ? 179 GLN C CB  1 
ATOM   9196  C CG  . GLN C 1 179 ? 43.731  86.353  11.953  1.00 84.28  ? 179 GLN C CG  1 
ATOM   9197  C CD  . GLN C 1 179 ? 44.060  86.064  10.503  1.00 79.54  ? 179 GLN C CD  1 
ATOM   9198  O OE1 . GLN C 1 179 ? 45.045  85.386  10.192  1.00 88.88  ? 179 GLN C OE1 1 
ATOM   9199  N NE2 . GLN C 1 179 ? 43.221  86.555  9.602   1.00 76.71  ? 179 GLN C NE2 1 
ATOM   9200  N N   . ASN C 1 180 ? 45.918  85.119  16.088  1.00 77.31  ? 180 ASN C N   1 
ATOM   9201  C CA  . ASN C 1 180 ? 47.081  85.002  16.954  1.00 82.23  ? 180 ASN C CA  1 
ATOM   9202  C C   . ASN C 1 180 ? 47.708  83.618  16.742  1.00 96.02  ? 180 ASN C C   1 
ATOM   9203  O O   . ASN C 1 180 ? 47.245  82.860  15.889  1.00 105.65 ? 180 ASN C O   1 
ATOM   9204  C CB  . ASN C 1 180 ? 46.727  85.336  18.402  1.00 73.23  ? 180 ASN C CB  1 
ATOM   9205  C CG  . ASN C 1 180 ? 45.782  84.332  19.019  1.00 78.09  ? 180 ASN C CG  1 
ATOM   9206  O OD1 . ASN C 1 180 ? 46.003  83.120  18.913  1.00 77.15  ? 180 ASN C OD1 1 
ATOM   9207  N ND2 . ASN C 1 180 ? 44.723  84.804  19.662  1.00 78.03  ? 180 ASN C ND2 1 
ATOM   9208  N N   . ASP C 1 181 ? 48.758  83.298  17.519  1.00 94.62  ? 181 ASP C N   1 
ATOM   9209  C CA  . ASP C 1 181 ? 49.555  82.090  17.325  1.00 93.04  ? 181 ASP C CA  1 
ATOM   9210  C C   . ASP C 1 181 ? 48.760  80.832  17.667  1.00 86.47  ? 181 ASP C C   1 
ATOM   9211  O O   . ASP C 1 181 ? 49.055  79.760  17.138  1.00 85.43  ? 181 ASP C O   1 
ATOM   9212  C CB  . ASP C 1 181 ? 50.839  82.081  18.152  1.00 94.90  ? 181 ASP C CB  1 
ATOM   9213  C CG  . ASP C 1 181 ? 51.944  83.035  17.711  1.00 92.06  ? 181 ASP C CG  1 
ATOM   9214  O OD1 . ASP C 1 181 ? 52.050  83.306  16.497  1.00 83.13  ? 181 ASP C OD1 1 
ATOM   9215  O OD2 . ASP C 1 181 ? 52.727  83.468  18.578  1.00 96.77  ? 181 ASP C OD2 1 
ATOM   9216  N N   . GLN C 1 182 ? 47.787  80.953  18.580  1.00 87.51  ? 182 GLN C N   1 
ATOM   9217  C CA  . GLN C 1 182 ? 47.052  79.793  19.054  1.00 84.43  ? 182 GLN C CA  1 
ATOM   9218  C C   . GLN C 1 182 ? 45.884  79.483  18.105  1.00 81.20  ? 182 GLN C C   1 
ATOM   9219  O O   . GLN C 1 182 ? 45.552  78.316  17.893  1.00 65.03  ? 182 GLN C O   1 
ATOM   9220  C CB  . GLN C 1 182 ? 46.667  79.983  20.523  1.00 87.59  ? 182 GLN C CB  1 
ATOM   9221  C CG  . GLN C 1 182 ? 46.674  78.679  21.319  1.00 95.63  ? 182 GLN C CG  1 
ATOM   9222  C CD  . GLN C 1 182 ? 45.857  78.719  22.596  1.00 94.35  ? 182 GLN C CD  1 
ATOM   9223  O OE1 . GLN C 1 182 ? 45.863  79.703  23.352  1.00 92.29  ? 182 GLN C OE1 1 
ATOM   9224  N NE2 . GLN C 1 182 ? 45.134  77.634  22.842  1.00 83.73  ? 182 GLN C NE2 1 
ATOM   9225  N N   . GLY C 1 183 ? 45.270  80.513  17.505  1.00 73.80  ? 183 GLY C N   1 
ATOM   9226  C CA  . GLY C 1 183 ? 44.118  80.299  16.641  1.00 78.24  ? 183 GLY C CA  1 
ATOM   9227  C C   . GLY C 1 183 ? 43.523  81.625  16.184  1.00 77.24  ? 183 GLY C C   1 
ATOM   9228  O O   . GLY C 1 183 ? 44.261  82.606  16.095  1.00 69.43  ? 183 GLY C O   1 
ATOM   9229  N N   . ILE C 1 184 ? 42.197  81.649  15.923  1.00 77.07  ? 184 ILE C N   1 
ATOM   9230  C CA  . ILE C 1 184 ? 41.515  82.875  15.502  1.00 70.80  ? 184 ILE C CA  1 
ATOM   9231  C C   . ILE C 1 184 ? 40.354  83.208  16.440  1.00 67.93  ? 184 ILE C C   1 
ATOM   9232  O O   . ILE C 1 184 ? 39.945  82.395  17.273  1.00 64.15  ? 184 ILE C O   1 
ATOM   9233  C CB  . ILE C 1 184 ? 41.040  82.812  14.034  1.00 68.54  ? 184 ILE C CB  1 
ATOM   9234  C CG1 . ILE C 1 184 ? 39.975  81.733  13.797  1.00 64.08  ? 184 ILE C CG1 1 
ATOM   9235  C CG2 . ILE C 1 184 ? 42.224  82.653  13.077  1.00 70.03  ? 184 ILE C CG2 1 
ATOM   9236  C CD1 . ILE C 1 184 ? 39.359  81.795  12.409  1.00 62.61  ? 184 ILE C CD1 1 
ATOM   9237  N N   . VAL C 1 185 ? 39.833  84.433  16.277  1.00 65.22  ? 185 VAL C N   1 
ATOM   9238  C CA  . VAL C 1 185 ? 38.677  84.905  17.021  1.00 64.38  ? 185 VAL C CA  1 
ATOM   9239  C C   . VAL C 1 185 ? 37.670  85.475  16.021  1.00 64.98  ? 185 VAL C C   1 
ATOM   9240  O O   . VAL C 1 185 ? 38.030  86.282  15.167  1.00 68.26  ? 185 VAL C O   1 
ATOM   9241  C CB  . VAL C 1 185 ? 39.065  85.943  18.098  1.00 64.76  ? 185 VAL C CB  1 
ATOM   9242  C CG1 . VAL C 1 185 ? 37.849  86.485  18.843  1.00 62.28  ? 185 VAL C CG1 1 
ATOM   9243  C CG2 . VAL C 1 185 ? 40.077  85.378  19.091  1.00 61.39  ? 185 VAL C CG2 1 
ATOM   9244  N N   . VAL C 1 186 ? 36.406  85.051  16.152  1.00 62.13  ? 186 VAL C N   1 
ATOM   9245  C CA  . VAL C 1 186 ? 35.365  85.353  15.181  1.00 63.40  ? 186 VAL C CA  1 
ATOM   9246  C C   . VAL C 1 186 ? 34.191  86.001  15.916  1.00 68.05  ? 186 VAL C C   1 
ATOM   9247  O O   . VAL C 1 186 ? 33.897  85.662  17.067  1.00 63.58  ? 186 VAL C O   1 
ATOM   9248  C CB  . VAL C 1 186 ? 34.931  84.080  14.418  1.00 65.73  ? 186 VAL C CB  1 
ATOM   9249  C CG1 . VAL C 1 186 ? 36.085  83.453  13.644  1.00 66.07  ? 186 VAL C CG1 1 
ATOM   9250  C CG2 . VAL C 1 186 ? 34.306  83.025  15.334  1.00 68.42  ? 186 VAL C CG2 1 
ATOM   9251  N N   . ARG C 1 187 ? 33.517  86.938  15.239  1.00 63.28  ? 187 ARG C N   1 
ATOM   9252  C CA  . ARG C 1 187 ? 32.382  87.622  15.826  1.00 62.92  ? 187 ARG C CA  1 
ATOM   9253  C C   . ARG C 1 187 ? 31.314  87.795  14.750  1.00 62.47  ? 187 ARG C C   1 
ATOM   9254  O O   . ARG C 1 187 ? 31.646  88.003  13.580  1.00 56.33  ? 187 ARG C O   1 
ATOM   9255  C CB  . ARG C 1 187 ? 32.789  88.973  16.429  1.00 66.05  ? 187 ARG C CB  1 
ATOM   9256  C CG  . ARG C 1 187 ? 31.762  89.555  17.395  1.00 74.13  ? 187 ARG C CG  1 
ATOM   9257  C CD  . ARG C 1 187 ? 31.974  91.026  17.760  1.00 78.54  ? 187 ARG C CD  1 
ATOM   9258  N NE  . ARG C 1 187 ? 33.288  91.265  18.368  1.00 84.12  ? 187 ARG C NE  1 
ATOM   9259  C CZ  . ARG C 1 187 ? 34.211  92.105  17.916  1.00 75.77  ? 187 ARG C CZ  1 
ATOM   9260  N NH1 . ARG C 1 187 ? 33.943  92.891  16.893  1.00 69.81  ? 187 ARG C NH1 1 
ATOM   9261  N NH2 . ARG C 1 187 ? 35.398  92.152  18.497  1.00 81.94  ? 187 ARG C NH2 1 
ATOM   9262  N N   . GLY C 1 188 ? 30.043  87.717  15.180  1.00 58.88  ? 188 GLY C N   1 
ATOM   9263  C CA  . GLY C 1 188 ? 28.887  87.860  14.306  1.00 62.18  ? 188 GLY C CA  1 
ATOM   9264  C C   . GLY C 1 188 ? 28.008  86.605  14.307  1.00 65.55  ? 188 GLY C C   1 
ATOM   9265  O O   . GLY C 1 188 ? 28.140  85.730  15.164  1.00 63.90  ? 188 GLY C O   1 
ATOM   9266  N N   . TRP C 1 189 ? 27.132  86.532  13.301  1.00 66.98  ? 189 TRP C N   1 
ATOM   9267  C CA  . TRP C 1 189 ? 26.092  85.523  13.190  1.00 63.07  ? 189 TRP C CA  1 
ATOM   9268  C C   . TRP C 1 189 ? 26.388  84.543  12.053  1.00 66.67  ? 189 TRP C C   1 
ATOM   9269  O O   . TRP C 1 189 ? 26.876  84.954  10.993  1.00 53.57  ? 189 TRP C O   1 
ATOM   9270  C CB  . TRP C 1 189 ? 24.757  86.205  12.880  1.00 61.37  ? 189 TRP C CB  1 
ATOM   9271  C CG  . TRP C 1 189 ? 24.194  87.063  13.978  1.00 60.82  ? 189 TRP C CG  1 
ATOM   9272  C CD1 . TRP C 1 189 ? 24.364  88.403  14.173  1.00 56.06  ? 189 TRP C CD1 1 
ATOM   9273  C CD2 . TRP C 1 189 ? 23.287  86.613  15.002  1.00 57.57  ? 189 TRP C CD2 1 
ATOM   9274  N NE1 . TRP C 1 189 ? 23.645  88.814  15.265  1.00 58.84  ? 189 TRP C NE1 1 
ATOM   9275  C CE2 . TRP C 1 189 ? 22.969  87.743  15.788  1.00 57.38  ? 189 TRP C CE2 1 
ATOM   9276  C CE3 . TRP C 1 189 ? 22.723  85.371  15.318  1.00 55.81  ? 189 TRP C CE3 1 
ATOM   9277  C CZ2 . TRP C 1 189 ? 22.108  87.662  16.878  1.00 60.77  ? 189 TRP C CZ2 1 
ATOM   9278  C CZ3 . TRP C 1 189 ? 21.867  85.294  16.393  1.00 56.97  ? 189 TRP C CZ3 1 
ATOM   9279  C CH2 . TRP C 1 189 ? 21.563  86.425  17.154  1.00 62.10  ? 189 TRP C CH2 1 
ATOM   9280  N N   . LYS C 1 190 ? 26.025  83.264  12.271  1.00 61.23  ? 190 LYS C N   1 
ATOM   9281  C CA  . LYS C 1 190 ? 25.699  82.359  11.176  1.00 57.81  ? 190 LYS C CA  1 
ATOM   9282  C C   . LYS C 1 190 ? 24.181  82.256  11.091  1.00 59.34  ? 190 LYS C C   1 
ATOM   9283  O O   . LYS C 1 190 ? 23.514  82.085  12.107  1.00 56.32  ? 190 LYS C O   1 
ATOM   9284  C CB  . LYS C 1 190 ? 26.362  80.984  11.301  1.00 51.94  ? 190 LYS C CB  1 
ATOM   9285  C CG  . LYS C 1 190 ? 27.861  81.015  11.101  1.00 56.17  ? 190 LYS C CG  1 
ATOM   9286  C CD  . LYS C 1 190 ? 28.312  81.720  9.821   1.00 58.56  ? 190 LYS C CD  1 
ATOM   9287  C CE  . LYS C 1 190 ? 27.982  80.946  8.578   1.00 60.11  ? 190 LYS C CE  1 
ATOM   9288  N NZ  . LYS C 1 190 ? 28.598  81.505  7.367   1.00 57.81  ? 190 LYS C NZ  1 
ATOM   9289  N N   . ALA C 1 191 ? 23.659  82.343  9.859   1.00 66.94  ? 191 ALA C N   1 
ATOM   9290  C CA  . ALA C 1 191 ? 22.271  82.719  9.626   1.00 73.08  ? 191 ALA C CA  1 
ATOM   9291  C C   . ALA C 1 191 ? 21.313  81.541  9.822   1.00 69.55  ? 191 ALA C C   1 
ATOM   9292  O O   . ALA C 1 191 ? 20.220  81.739  10.336  1.00 74.38  ? 191 ALA C O   1 
ATOM   9293  C CB  . ALA C 1 191 ? 22.134  83.334  8.251   1.00 75.39  ? 191 ALA C CB  1 
ATOM   9294  N N   . MET C 1 192 ? 21.691  80.321  9.415   1.00 65.09  ? 192 MET C N   1 
ATOM   9295  C CA  . MET C 1 192 ? 20.780  79.209  9.598   1.00 69.43  ? 192 MET C CA  1 
ATOM   9296  C C   . MET C 1 192 ? 21.510  77.878  9.573   1.00 68.48  ? 192 MET C C   1 
ATOM   9297  O O   . MET C 1 192 ? 22.523  77.720  8.886   1.00 72.96  ? 192 MET C O   1 
ATOM   9298  C CB  . MET C 1 192 ? 19.697  79.142  8.518   1.00 85.32  ? 192 MET C CB  1 
ATOM   9299  C CG  . MET C 1 192 ? 18.334  78.773  9.086   1.00 92.60  ? 192 MET C CG  1 
ATOM   9300  S SD  . MET C 1 192 ? 17.383  77.760  7.945   1.00 114.36 ? 192 MET C SD  1 
ATOM   9301  C CE  . MET C 1 192 ? 17.730  78.623  6.407   1.00 104.11 ? 192 MET C CE  1 
ATOM   9302  N N   . GLY C 1 193 ? 20.936  76.946  10.346  1.00 51.85  ? 193 GLY C N   1 
ATOM   9303  C CA  . GLY C 1 193 ? 21.482  75.619  10.549  1.00 50.81  ? 193 GLY C CA  1 
ATOM   9304  C C   . GLY C 1 193 ? 20.436  74.751  11.245  1.00 56.93  ? 193 GLY C C   1 
ATOM   9305  O O   . GLY C 1 193 ? 19.507  75.273  11.873  1.00 59.27  ? 193 GLY C O   1 
ATOM   9306  N N   . THR C 1 194 ? 20.601  73.434  11.110  1.00 48.82  ? 194 THR C N   1 
ATOM   9307  C CA  . THR C 1 194 ? 19.564  72.489  11.471  1.00 57.30  ? 194 THR C CA  1 
ATOM   9308  C C   . THR C 1 194 ? 20.119  71.498  12.488  1.00 54.94  ? 194 THR C C   1 
ATOM   9309  O O   . THR C 1 194 ? 21.271  71.080  12.389  1.00 48.95  ? 194 THR C O   1 
ATOM   9310  C CB  . THR C 1 194 ? 19.051  71.796  10.209  1.00 66.82  ? 194 THR C CB  1 
ATOM   9311  O OG1 . THR C 1 194 ? 18.530  72.854  9.403   1.00 69.62  ? 194 THR C OG1 1 
ATOM   9312  C CG2 . THR C 1 194 ? 17.955  70.786  10.507  1.00 68.75  ? 194 THR C CG2 1 
ATOM   9313  N N   . SER C 1 195 ? 19.272  71.169  13.474  1.00 50.15  ? 195 SER C N   1 
ATOM   9314  C CA  . SER C 1 195 ? 19.603  70.252  14.547  1.00 53.53  ? 195 SER C CA  1 
ATOM   9315  C C   . SER C 1 195 ? 20.690  70.813  15.472  1.00 50.14  ? 195 SER C C   1 
ATOM   9316  O O   . SER C 1 195 ? 21.372  70.036  16.129  1.00 55.84  ? 195 SER C O   1 
ATOM   9317  C CB  . SER C 1 195 ? 20.035  68.912  13.974  1.00 57.24  ? 195 SER C CB  1 
ATOM   9318  O OG  . SER C 1 195 ? 19.302  68.558  12.811  1.00 52.31  ? 195 SER C OG  1 
ATOM   9319  N N   . LEU C 1 196 ? 20.847  72.142  15.548  1.00 59.93  ? 196 LEU C N   1 
ATOM   9320  C CA  . LEU C 1 196 ? 21.956  72.769  16.269  1.00 58.36  ? 196 LEU C CA  1 
ATOM   9321  C C   . LEU C 1 196 ? 22.023  72.297  17.727  1.00 53.10  ? 196 LEU C C   1 
ATOM   9322  O O   . LEU C 1 196 ? 23.114  71.977  18.204  1.00 53.50  ? 196 LEU C O   1 
ATOM   9323  C CB  . LEU C 1 196 ? 21.914  74.298  16.211  1.00 55.71  ? 196 LEU C CB  1 
ATOM   9324  C CG  . LEU C 1 196 ? 21.923  74.935  14.817  1.00 65.32  ? 196 LEU C CG  1 
ATOM   9325  C CD1 . LEU C 1 196 ? 22.069  76.450  14.961  1.00 65.85  ? 196 LEU C CD1 1 
ATOM   9326  C CD2 . LEU C 1 196 ? 23.003  74.349  13.895  1.00 67.52  ? 196 LEU C CD2 1 
ATOM   9327  N N   . PRO C 1 197 ? 20.898  72.199  18.479  1.00 46.64  ? 197 PRO C N   1 
ATOM   9328  C CA  . PRO C 1 197 ? 20.960  71.786  19.877  1.00 50.01  ? 197 PRO C CA  1 
ATOM   9329  C C   . PRO C 1 197 ? 21.193  70.289  20.093  1.00 51.76  ? 197 PRO C C   1 
ATOM   9330  O O   . PRO C 1 197 ? 21.294  69.845  21.241  1.00 57.84  ? 197 PRO C O   1 
ATOM   9331  C CB  . PRO C 1 197 ? 19.610  72.253  20.484  1.00 52.73  ? 197 PRO C CB  1 
ATOM   9332  C CG  . PRO C 1 197 ? 18.776  72.759  19.322  1.00 54.77  ? 197 PRO C CG  1 
ATOM   9333  C CD  . PRO C 1 197 ? 19.520  72.442  18.036  1.00 53.36  ? 197 PRO C CD  1 
ATOM   9334  N N   . PHE C 1 198 ? 21.288  69.519  18.999  1.00 50.04  ? 198 PHE C N   1 
ATOM   9335  C CA  . PHE C 1 198 ? 21.389  68.067  19.066  1.00 47.56  ? 198 PHE C CA  1 
ATOM   9336  C C   . PHE C 1 198 ? 22.695  67.575  18.433  1.00 50.26  ? 198 PHE C C   1 
ATOM   9337  O O   . PHE C 1 198 ? 22.832  66.368  18.202  1.00 51.51  ? 198 PHE C O   1 
ATOM   9338  C CB  . PHE C 1 198 ? 20.130  67.493  18.407  1.00 47.75  ? 198 PHE C CB  1 
ATOM   9339  C CG  . PHE C 1 198 ? 18.838  68.094  18.954  1.00 52.46  ? 198 PHE C CG  1 
ATOM   9340  C CD1 . PHE C 1 198 ? 18.312  67.674  20.176  1.00 58.18  ? 198 PHE C CD1 1 
ATOM   9341  C CD2 . PHE C 1 198 ? 18.162  69.100  18.262  1.00 50.22  ? 198 PHE C CD2 1 
ATOM   9342  C CE1 . PHE C 1 198 ? 17.141  68.242  20.683  1.00 59.43  ? 198 PHE C CE1 1 
ATOM   9343  C CE2 . PHE C 1 198 ? 16.981  69.646  18.760  1.00 52.72  ? 198 PHE C CE2 1 
ATOM   9344  C CZ  . PHE C 1 198 ? 16.476  69.224  19.974  1.00 52.88  ? 198 PHE C CZ  1 
ATOM   9345  N N   . VAL C 1 199 ? 23.650  68.490  18.169  1.00 45.25  ? 199 VAL C N   1 
ATOM   9346  C CA  . VAL C 1 199 ? 24.977  68.093  17.704  1.00 50.33  ? 199 VAL C CA  1 
ATOM   9347  C C   . VAL C 1 199 ? 26.063  68.513  18.704  1.00 49.48  ? 199 VAL C C   1 
ATOM   9348  O O   . VAL C 1 199 ? 25.799  69.212  19.678  1.00 58.59  ? 199 VAL C O   1 
ATOM   9349  C CB  . VAL C 1 199 ? 25.267  68.610  16.280  1.00 49.31  ? 199 VAL C CB  1 
ATOM   9350  C CG1 . VAL C 1 199 ? 24.298  67.985  15.275  1.00 51.99  ? 199 VAL C CG1 1 
ATOM   9351  C CG2 . VAL C 1 199 ? 25.280  70.133  16.174  1.00 46.18  ? 199 VAL C CG2 1 
ATOM   9352  N N   . ASN C 1 200 ? 27.295  68.054  18.450  1.00 50.11  ? 200 ASN C N   1 
ATOM   9353  C CA  . ASN C 1 200 ? 28.446  68.278  19.315  1.00 47.75  ? 200 ASN C CA  1 
ATOM   9354  C C   . ASN C 1 200 ? 29.267  69.456  18.788  1.00 53.63  ? 200 ASN C C   1 
ATOM   9355  O O   . ASN C 1 200 ? 29.770  70.258  19.572  1.00 45.48  ? 200 ASN C O   1 
ATOM   9356  C CB  . ASN C 1 200 ? 29.289  67.010  19.428  1.00 46.91  ? 200 ASN C CB  1 
ATOM   9357  C CG  . ASN C 1 200 ? 28.465  65.840  19.925  1.00 52.92  ? 200 ASN C CG  1 
ATOM   9358  O OD1 . ASN C 1 200 ? 28.201  64.883  19.180  1.00 51.65  ? 200 ASN C OD1 1 
ATOM   9359  N ND2 . ASN C 1 200 ? 27.992  65.914  21.162  1.00 51.81  ? 200 ASN C ND2 1 
ATOM   9360  N N   . GLU C 1 201 ? 29.382  69.572  17.453  1.00 56.86  ? 201 GLU C N   1 
ATOM   9361  C CA  . GLU C 1 201 ? 30.269  70.542  16.822  1.00 54.74  ? 201 GLU C CA  1 
ATOM   9362  C C   . GLU C 1 201 ? 29.594  71.086  15.568  1.00 52.46  ? 201 GLU C C   1 
ATOM   9363  O O   . GLU C 1 201 ? 28.897  70.333  14.900  1.00 52.90  ? 201 GLU C O   1 
ATOM   9364  C CB  . GLU C 1 201 ? 31.593  69.871  16.433  1.00 54.86  ? 201 GLU C CB  1 
ATOM   9365  C CG  . GLU C 1 201 ? 32.454  69.432  17.617  1.00 59.63  ? 201 GLU C CG  1 
ATOM   9366  C CD  . GLU C 1 201 ? 33.735  68.650  17.352  1.00 58.62  ? 201 GLU C CD  1 
ATOM   9367  O OE1 . GLU C 1 201 ? 34.195  68.017  18.317  1.00 56.06  ? 201 GLU C OE1 1 
ATOM   9368  O OE2 . GLU C 1 201 ? 34.281  68.657  16.235  1.00 63.42  ? 201 GLU C OE2 1 
ATOM   9369  N N   . LEU C 1 202 ? 29.832  72.371  15.258  1.00 49.62  ? 202 LEU C N   1 
ATOM   9370  C CA  . LEU C 1 202 ? 29.402  72.998  14.015  1.00 48.81  ? 202 LEU C CA  1 
ATOM   9371  C C   . LEU C 1 202 ? 30.509  72.994  12.965  1.00 54.88  ? 202 LEU C C   1 
ATOM   9372  O O   . LEU C 1 202 ? 31.691  73.123  13.285  1.00 51.22  ? 202 LEU C O   1 
ATOM   9373  C CB  . LEU C 1 202 ? 28.976  74.430  14.308  1.00 50.75  ? 202 LEU C CB  1 
ATOM   9374  C CG  . LEU C 1 202 ? 27.912  74.577  15.396  1.00 55.35  ? 202 LEU C CG  1 
ATOM   9375  C CD1 . LEU C 1 202 ? 27.607  76.050  15.587  1.00 52.22  ? 202 LEU C CD1 1 
ATOM   9376  C CD2 . LEU C 1 202 ? 26.671  73.756  15.064  1.00 51.30  ? 202 LEU C CD2 1 
ATOM   9377  N N   . LEU C 1 203 ? 30.089  72.867  11.697  1.00 62.08  ? 203 LEU C N   1 
ATOM   9378  C CA  . LEU C 1 203 ? 30.943  73.065  10.534  1.00 60.97  ? 203 LEU C CA  1 
ATOM   9379  C C   . LEU C 1 203 ? 30.588  74.410  9.916   1.00 59.81  ? 203 LEU C C   1 
ATOM   9380  O O   . LEU C 1 203 ? 29.655  74.474  9.128   1.00 59.15  ? 203 LEU C O   1 
ATOM   9381  C CB  . LEU C 1 203 ? 30.696  71.928  9.540   1.00 61.36  ? 203 LEU C CB  1 
ATOM   9382  C CG  . LEU C 1 203 ? 31.170  70.536  9.967   1.00 67.71  ? 203 LEU C CG  1 
ATOM   9383  C CD1 . LEU C 1 203 ? 30.473  69.417  9.203   1.00 69.79  ? 203 LEU C CD1 1 
ATOM   9384  C CD2 . LEU C 1 203 ? 32.682  70.441  9.786   1.00 69.97  ? 203 LEU C CD2 1 
ATOM   9385  N N   . VAL C 1 204 ? 31.277  75.491  10.303  1.00 61.67  ? 204 VAL C N   1 
ATOM   9386  C CA  . VAL C 1 204 ? 30.912  76.809  9.799   1.00 63.30  ? 204 VAL C CA  1 
ATOM   9387  C C   . VAL C 1 204 ? 31.658  77.015  8.485   1.00 58.46  ? 204 VAL C C   1 
ATOM   9388  O O   . VAL C 1 204 ? 32.797  76.592  8.353   1.00 50.89  ? 204 VAL C O   1 
ATOM   9389  C CB  . VAL C 1 204 ? 31.132  78.007  10.749  1.00 67.15  ? 204 VAL C CB  1 
ATOM   9390  C CG1 . VAL C 1 204 ? 30.488  77.771  12.112  1.00 67.07  ? 204 VAL C CG1 1 
ATOM   9391  C CG2 . VAL C 1 204 ? 32.606  78.367  10.905  1.00 72.54  ? 204 VAL C CG2 1 
ATOM   9392  N N   . GLY C 1 205 ? 30.978  77.650  7.526   1.00 59.99  ? 205 GLY C N   1 
ATOM   9393  C CA  . GLY C 1 205 ? 31.545  78.000  6.235   1.00 60.76  ? 205 GLY C CA  1 
ATOM   9394  C C   . GLY C 1 205 ? 30.737  79.118  5.573   1.00 60.85  ? 205 GLY C C   1 
ATOM   9395  O O   . GLY C 1 205 ? 29.795  79.642  6.157   1.00 64.18  ? 205 GLY C O   1 
ATOM   9396  N N   . ASN C 1 206 ? 31.121  79.469  4.345   1.00 64.18  ? 206 ASN C N   1 
ATOM   9397  C CA  . ASN C 1 206 ? 30.454  80.494  3.564   1.00 66.50  ? 206 ASN C CA  1 
ATOM   9398  C C   . ASN C 1 206 ? 30.144  79.937  2.182   1.00 74.42  ? 206 ASN C C   1 
ATOM   9399  O O   . ASN C 1 206 ? 30.826  79.030  1.721   1.00 64.78  ? 206 ASN C O   1 
ATOM   9400  C CB  . ASN C 1 206 ? 31.337  81.727  3.418   1.00 71.99  ? 206 ASN C CB  1 
ATOM   9401  C CG  . ASN C 1 206 ? 31.995  82.087  4.728   1.00 71.48  ? 206 ASN C CG  1 
ATOM   9402  O OD1 . ASN C 1 206 ? 32.972  81.451  5.127   1.00 75.07  ? 206 ASN C OD1 1 
ATOM   9403  N ND2 . ASN C 1 206 ? 31.481  83.098  5.409   1.00 73.07  ? 206 ASN C ND2 1 
ATOM   9404  N N   . LEU C 1 207 ? 29.104  80.478  1.542   1.00 87.23  ? 207 LEU C N   1 
ATOM   9405  C CA  . LEU C 1 207 ? 28.951  80.399  0.097   1.00 89.62  ? 207 LEU C CA  1 
ATOM   9406  C C   . LEU C 1 207 ? 29.096  81.817  -0.438  1.00 83.56  ? 207 LEU C C   1 
ATOM   9407  O O   . LEU C 1 207 ? 28.544  82.736  0.160   1.00 79.10  ? 207 LEU C O   1 
ATOM   9408  C CB  . LEU C 1 207 ? 27.589  79.811  -0.258  1.00 84.15  ? 207 LEU C CB  1 
ATOM   9409  C CG  . LEU C 1 207 ? 27.327  78.389  0.234   1.00 82.40  ? 207 LEU C CG  1 
ATOM   9410  C CD1 . LEU C 1 207 ? 25.976  78.360  0.937   1.00 86.28  ? 207 LEU C CD1 1 
ATOM   9411  C CD2 . LEU C 1 207 ? 27.378  77.386  -0.920  1.00 87.29  ? 207 LEU C CD2 1 
ATOM   9412  N N   . TRP C 1 208 ? 29.819  81.992  -1.552  1.00 80.12  ? 208 TRP C N   1 
ATOM   9413  C CA  . TRP C 1 208 ? 30.180  83.334  -1.986  1.00 85.16  ? 208 TRP C CA  1 
ATOM   9414  C C   . TRP C 1 208 ? 28.936  84.192  -2.241  1.00 82.35  ? 208 TRP C C   1 
ATOM   9415  O O   . TRP C 1 208 ? 27.994  83.778  -2.909  1.00 82.99  ? 208 TRP C O   1 
ATOM   9416  C CB  . TRP C 1 208 ? 31.104  83.307  -3.213  1.00 89.57  ? 208 TRP C CB  1 
ATOM   9417  C CG  . TRP C 1 208 ? 31.567  84.680  -3.628  1.00 95.41  ? 208 TRP C CG  1 
ATOM   9418  C CD1 . TRP C 1 208 ? 32.553  85.429  -3.050  1.00 97.88  ? 208 TRP C CD1 1 
ATOM   9419  C CD2 . TRP C 1 208 ? 31.033  85.481  -4.707  1.00 101.30 ? 208 TRP C CD2 1 
ATOM   9420  N NE1 . TRP C 1 208 ? 32.671  86.637  -3.686  1.00 96.49  ? 208 TRP C NE1 1 
ATOM   9421  C CE2 . TRP C 1 208 ? 31.756  86.698  -4.708  1.00 95.63  ? 208 TRP C CE2 1 
ATOM   9422  C CE3 . TRP C 1 208 ? 30.028  85.286  -5.665  1.00 95.84  ? 208 TRP C CE3 1 
ATOM   9423  C CZ2 . TRP C 1 208 ? 31.501  87.711  -5.632  1.00 89.48  ? 208 TRP C CZ2 1 
ATOM   9424  C CZ3 . TRP C 1 208 ? 29.781  86.287  -6.579  1.00 95.57  ? 208 TRP C CZ3 1 
ATOM   9425  C CH2 . TRP C 1 208 ? 30.503  87.484  -6.556  1.00 92.65  ? 208 TRP C CH2 1 
ATOM   9426  N N   . ARG C 1 209 ? 28.958  85.393  -1.656  1.00 88.87  ? 209 ARG C N   1 
ATOM   9427  C CA  . ARG C 1 209 ? 28.029  86.468  -1.954  1.00 102.16 ? 209 ARG C CA  1 
ATOM   9428  C C   . ARG C 1 209 ? 28.847  87.668  -2.444  1.00 113.58 ? 209 ARG C C   1 
ATOM   9429  O O   . ARG C 1 209 ? 30.026  87.795  -2.098  1.00 94.81  ? 209 ARG C O   1 
ATOM   9430  C CB  . ARG C 1 209 ? 27.202  86.767  -0.697  1.00 108.94 ? 209 ARG C CB  1 
ATOM   9431  C CG  . ARG C 1 209 ? 27.994  86.731  0.605   1.00 121.00 ? 209 ARG C CG  1 
ATOM   9432  C CD  . ARG C 1 209 ? 27.277  87.395  1.777   1.00 129.32 ? 209 ARG C CD  1 
ATOM   9433  N NE  . ARG C 1 209 ? 27.143  88.847  1.597   1.00 136.04 ? 209 ARG C NE  1 
ATOM   9434  C CZ  . ARG C 1 209 ? 28.102  89.765  1.748   1.00 134.43 ? 209 ARG C CZ  1 
ATOM   9435  N NH1 . ARG C 1 209 ? 29.308  89.436  2.183   1.00 138.78 ? 209 ARG C NH1 1 
ATOM   9436  N NH2 . ARG C 1 209 ? 27.838  91.033  1.488   1.00 128.69 ? 209 ARG C NH2 1 
ATOM   9437  N N   . PRO C 1 210 ? 28.285  88.572  -3.288  1.00 122.39 ? 210 PRO C N   1 
ATOM   9438  C CA  . PRO C 1 210 ? 29.033  89.744  -3.767  1.00 114.65 ? 210 PRO C CA  1 
ATOM   9439  C C   . PRO C 1 210 ? 29.439  90.733  -2.670  1.00 105.21 ? 210 PRO C C   1 
ATOM   9440  O O   . PRO C 1 210 ? 28.599  91.176  -1.888  1.00 92.15  ? 210 PRO C O   1 
ATOM   9441  C CB  . PRO C 1 210 ? 28.075  90.387  -4.808  1.00 111.07 ? 210 PRO C CB  1 
ATOM   9442  C CG  . PRO C 1 210 ? 27.098  89.284  -5.166  1.00 107.09 ? 210 PRO C CG  1 
ATOM   9443  C CD  . PRO C 1 210 ? 26.938  88.483  -3.882  1.00 112.54 ? 210 PRO C CD  1 
ATOM   9444  N N   . GLY C 1 211 ? 30.735  91.085  -2.640  1.00 104.72 ? 211 GLY C N   1 
ATOM   9445  C CA  . GLY C 1 211 ? 31.287  92.004  -1.656  1.00 100.66 ? 211 GLY C CA  1 
ATOM   9446  C C   . GLY C 1 211 ? 31.871  91.272  -0.446  1.00 111.24 ? 211 GLY C C   1 
ATOM   9447  O O   . GLY C 1 211 ? 32.223  91.907  0.552   1.00 111.33 ? 211 GLY C O   1 
ATOM   9448  N N   . GLN C 1 212 ? 31.980  89.936  -0.549  1.00 113.01 ? 212 GLN C N   1 
ATOM   9449  C CA  . GLN C 1 212 ? 32.554  89.113  0.506   1.00 103.67 ? 212 GLN C CA  1 
ATOM   9450  C C   . GLN C 1 212 ? 34.028  89.486  0.700   1.00 95.17  ? 212 GLN C C   1 
ATOM   9451  O O   . GLN C 1 212 ? 34.822  89.409  -0.236  1.00 77.90  ? 212 GLN C O   1 
ATOM   9452  C CB  . GLN C 1 212 ? 32.363  87.620  0.214   1.00 95.13  ? 212 GLN C CB  1 
ATOM   9453  C CG  . GLN C 1 212 ? 32.976  86.707  1.272   1.00 91.40  ? 212 GLN C CG  1 
ATOM   9454  C CD  . GLN C 1 212 ? 32.256  85.387  1.436   1.00 97.38  ? 212 GLN C CD  1 
ATOM   9455  O OE1 . GLN C 1 212 ? 31.021  85.329  1.488   1.00 106.06 ? 212 GLN C OE1 1 
ATOM   9456  N NE2 . GLN C 1 212 ? 33.026  84.313  1.543   1.00 91.35  ? 212 GLN C NE2 1 
ATOM   9457  N N   . THR C 1 213 ? 34.380  89.879  1.935   1.00 93.30  ? 213 THR C N   1 
ATOM   9458  C CA  . THR C 1 213 ? 35.739  90.271  2.283   1.00 85.23  ? 213 THR C CA  1 
ATOM   9459  C C   . THR C 1 213 ? 36.538  89.030  2.691   1.00 81.66  ? 213 THR C C   1 
ATOM   9460  O O   . THR C 1 213 ? 36.020  87.912  2.768   1.00 77.55  ? 213 THR C O   1 
ATOM   9461  C CB  . THR C 1 213 ? 35.715  91.329  3.393   1.00 74.90  ? 213 THR C CB  1 
ATOM   9462  O OG1 . THR C 1 213 ? 35.439  90.635  4.605   1.00 72.43  ? 213 THR C OG1 1 
ATOM   9463  C CG2 . THR C 1 213 ? 34.665  92.407  3.170   1.00 73.39  ? 213 THR C CG2 1 
ATOM   9464  N N   . SER C 1 214 ? 37.827  89.250  2.943   1.00 82.99  ? 214 SER C N   1 
ATOM   9465  C CA  . SER C 1 214 ? 38.755  88.188  3.298   1.00 81.59  ? 214 SER C CA  1 
ATOM   9466  C C   . SER C 1 214 ? 38.425  87.652  4.693   1.00 75.89  ? 214 SER C C   1 
ATOM   9467  O O   . SER C 1 214 ? 38.263  86.449  4.877   1.00 67.13  ? 214 SER C O   1 
ATOM   9468  C CB  . SER C 1 214 ? 40.183  88.709  3.200   1.00 78.66  ? 214 SER C CB  1 
ATOM   9469  O OG  . SER C 1 214 ? 41.138  87.735  3.591   1.00 71.71  ? 214 SER C OG  1 
ATOM   9470  N N   . ASP C 1 215 ? 38.291  88.574  5.656   1.00 75.62  ? 215 ASP C N   1 
ATOM   9471  C CA  . ASP C 1 215 ? 38.049  88.260  7.056   1.00 82.26  ? 215 ASP C CA  1 
ATOM   9472  C C   . ASP C 1 215 ? 36.648  87.690  7.275   1.00 81.88  ? 215 ASP C C   1 
ATOM   9473  O O   . ASP C 1 215 ? 36.360  87.234  8.381   1.00 72.54  ? 215 ASP C O   1 
ATOM   9474  C CB  . ASP C 1 215 ? 38.186  89.497  7.939   1.00 87.34  ? 215 ASP C CB  1 
ATOM   9475  C CG  . ASP C 1 215 ? 39.589  90.029  8.215   1.00 82.13  ? 215 ASP C CG  1 
ATOM   9476  O OD1 . ASP C 1 215 ? 39.696  91.245  8.461   1.00 74.45  ? 215 ASP C OD1 1 
ATOM   9477  O OD2 . ASP C 1 215 ? 40.551  89.227  8.235   1.00 81.64  ? 215 ASP C OD2 1 
ATOM   9478  N N   . GLN C 1 216 ? 35.779  87.752  6.249   1.00 82.08  ? 216 GLN C N   1 
ATOM   9479  C CA  . GLN C 1 216 ? 34.442  87.171  6.310   1.00 83.18  ? 216 GLN C CA  1 
ATOM   9480  C C   . GLN C 1 216 ? 34.445  85.709  5.839   1.00 82.66  ? 216 GLN C C   1 
ATOM   9481  O O   . GLN C 1 216 ? 33.398  85.063  5.880   1.00 83.72  ? 216 GLN C O   1 
ATOM   9482  C CB  . GLN C 1 216 ? 33.450  87.983  5.468   1.00 85.45  ? 216 GLN C CB  1 
ATOM   9483  C CG  . GLN C 1 216 ? 33.000  89.306  6.084   1.00 85.70  ? 216 GLN C CG  1 
ATOM   9484  C CD  . GLN C 1 216 ? 32.185  90.192  5.155   1.00 82.28  ? 216 GLN C CD  1 
ATOM   9485  O OE1 . GLN C 1 216 ? 32.028  89.945  3.954   1.00 81.71  ? 216 GLN C OE1 1 
ATOM   9486  N NE2 . GLN C 1 216 ? 31.649  91.267  5.709   1.00 83.81  ? 216 GLN C NE2 1 
ATOM   9487  N N   . THR C 1 217 ? 35.609  85.181  5.414   1.00 74.00  ? 217 THR C N   1 
ATOM   9488  C CA  . THR C 1 217 ? 35.706  83.835  4.846   1.00 81.19  ? 217 THR C CA  1 
ATOM   9489  C C   . THR C 1 217 ? 36.281  82.849  5.881   1.00 79.83  ? 217 THR C C   1 
ATOM   9490  O O   . THR C 1 217 ? 37.492  82.803  6.103   1.00 75.47  ? 217 THR C O   1 
ATOM   9491  C CB  . THR C 1 217 ? 36.547  83.878  3.558   1.00 79.50  ? 217 THR C CB  1 
ATOM   9492  O OG1 . THR C 1 217 ? 36.161  84.993  2.749   1.00 78.50  ? 217 THR C OG1 1 
ATOM   9493  C CG2 . THR C 1 217 ? 36.436  82.597  2.746   1.00 74.03  ? 217 THR C CG2 1 
ATOM   9494  N N   . VAL C 1 218 ? 35.409  82.018  6.484   1.00 73.83  ? 218 VAL C N   1 
ATOM   9495  C CA  . VAL C 1 218 ? 35.797  81.112  7.557   1.00 71.08  ? 218 VAL C CA  1 
ATOM   9496  C C   . VAL C 1 218 ? 35.204  79.726  7.316   1.00 73.53  ? 218 VAL C C   1 
ATOM   9497  O O   . VAL C 1 218 ? 33.983  79.605  7.243   1.00 75.97  ? 218 VAL C O   1 
ATOM   9498  C CB  . VAL C 1 218 ? 35.289  81.646  8.907   1.00 70.43  ? 218 VAL C CB  1 
ATOM   9499  C CG1 . VAL C 1 218 ? 35.938  80.916  10.079  1.00 67.24  ? 218 VAL C CG1 1 
ATOM   9500  C CG2 . VAL C 1 218 ? 35.470  83.154  9.019   1.00 76.99  ? 218 VAL C CG2 1 
ATOM   9501  N N   . TYR C 1 219 ? 36.065  78.692  7.254   1.00 71.26  ? 219 TYR C N   1 
ATOM   9502  C CA  . TYR C 1 219 ? 35.642  77.294  7.341   1.00 69.49  ? 219 TYR C CA  1 
ATOM   9503  C C   . TYR C 1 219 ? 36.325  76.651  8.545   1.00 70.33  ? 219 TYR C C   1 
ATOM   9504  O O   . TYR C 1 219 ? 37.559  76.606  8.596   1.00 72.75  ? 219 TYR C O   1 
ATOM   9505  C CB  . TYR C 1 219 ? 35.937  76.474  6.076   1.00 63.25  ? 219 TYR C CB  1 
ATOM   9506  C CG  . TYR C 1 219 ? 35.291  77.094  4.845   1.00 69.95  ? 219 TYR C CG  1 
ATOM   9507  C CD1 . TYR C 1 219 ? 35.802  78.276  4.312   1.00 71.56  ? 219 TYR C CD1 1 
ATOM   9508  C CD2 . TYR C 1 219 ? 34.157  76.540  4.247   1.00 60.09  ? 219 TYR C CD2 1 
ATOM   9509  C CE1 . TYR C 1 219 ? 35.220  78.883  3.211   1.00 75.16  ? 219 TYR C CE1 1 
ATOM   9510  C CE2 . TYR C 1 219 ? 33.571  77.136  3.140   1.00 63.12  ? 219 TYR C CE2 1 
ATOM   9511  C CZ  . TYR C 1 219 ? 34.106  78.310  2.622   1.00 72.02  ? 219 TYR C CZ  1 
ATOM   9512  O OH  . TYR C 1 219 ? 33.588  78.952  1.530   1.00 61.06  ? 219 TYR C OH  1 
ATOM   9513  N N   . ALA C 1 220 ? 35.523  76.145  9.497   1.00 58.32  ? 220 ALA C N   1 
ATOM   9514  C CA  . ALA C 1 220 ? 36.078  75.681  10.758  1.00 63.07  ? 220 ALA C CA  1 
ATOM   9515  C C   . ALA C 1 220 ? 35.110  74.769  11.507  1.00 63.08  ? 220 ALA C C   1 
ATOM   9516  O O   . ALA C 1 220 ? 33.896  74.897  11.372  1.00 68.63  ? 220 ALA C O   1 
ATOM   9517  C CB  . ALA C 1 220 ? 36.453  76.879  11.604  1.00 65.44  ? 220 ALA C CB  1 
ATOM   9518  N N   . ILE C 1 221 ? 35.672  73.852  12.306  1.00 61.42  ? 221 ILE C N   1 
ATOM   9519  C CA  . ILE C 1 221 ? 34.898  73.095  13.271  1.00 63.26  ? 221 ILE C CA  1 
ATOM   9520  C C   . ILE C 1 221 ? 34.868  73.869  14.591  1.00 64.28  ? 221 ILE C C   1 
ATOM   9521  O O   . ILE C 1 221 ? 35.898  74.370  15.057  1.00 66.00  ? 221 ILE C O   1 
ATOM   9522  C CB  . ILE C 1 221 ? 35.462  71.676  13.447  1.00 73.32  ? 221 ILE C CB  1 
ATOM   9523  C CG1 . ILE C 1 221 ? 35.473  70.908  12.133  1.00 83.72  ? 221 ILE C CG1 1 
ATOM   9524  C CG2 . ILE C 1 221 ? 34.678  70.918  14.516  1.00 80.41  ? 221 ILE C CG2 1 
ATOM   9525  C CD1 . ILE C 1 221 ? 36.075  69.515  12.223  1.00 86.53  ? 221 ILE C CD1 1 
ATOM   9526  N N   . VAL C 1 222 ? 33.664  73.966  15.177  1.00 52.33  ? 222 VAL C N   1 
ATOM   9527  C CA  . VAL C 1 222 ? 33.451  74.696  16.415  1.00 52.50  ? 222 VAL C CA  1 
ATOM   9528  C C   . VAL C 1 222 ? 32.528  73.897  17.345  1.00 58.57  ? 222 VAL C C   1 
ATOM   9529  O O   . VAL C 1 222 ? 31.334  73.718  17.073  1.00 51.72  ? 222 VAL C O   1 
ATOM   9530  C CB  . VAL C 1 222 ? 32.894  76.106  16.161  1.00 53.89  ? 222 VAL C CB  1 
ATOM   9531  C CG1 . VAL C 1 222 ? 32.649  76.854  17.473  1.00 53.71  ? 222 VAL C CG1 1 
ATOM   9532  C CG2 . VAL C 1 222 ? 33.803  76.900  15.233  1.00 55.32  ? 222 VAL C CG2 1 
ATOM   9533  N N   . PRO C 1 223 ? 33.046  73.409  18.498  1.00 57.90  ? 223 PRO C N   1 
ATOM   9534  C CA  . PRO C 1 223 ? 32.205  72.691  19.456  1.00 58.42  ? 223 PRO C CA  1 
ATOM   9535  C C   . PRO C 1 223 ? 31.009  73.543  19.873  1.00 54.93  ? 223 PRO C C   1 
ATOM   9536  O O   . PRO C 1 223 ? 31.143  74.751  20.017  1.00 49.51  ? 223 PRO C O   1 
ATOM   9537  C CB  . PRO C 1 223 ? 33.184  72.389  20.609  1.00 61.74  ? 223 PRO C CB  1 
ATOM   9538  C CG  . PRO C 1 223 ? 34.548  72.365  19.945  1.00 63.54  ? 223 PRO C CG  1 
ATOM   9539  C CD  . PRO C 1 223 ? 34.461  73.486  18.916  1.00 60.78  ? 223 PRO C CD  1 
ATOM   9540  N N   . VAL C 1 224 ? 29.843  72.915  20.075  1.00 55.29  ? 224 VAL C N   1 
ATOM   9541  C CA  . VAL C 1 224 ? 28.623  73.673  20.312  1.00 58.79  ? 224 VAL C CA  1 
ATOM   9542  C C   . VAL C 1 224 ? 28.724  74.453  21.628  1.00 56.63  ? 224 VAL C C   1 
ATOM   9543  O O   . VAL C 1 224 ? 28.178  75.543  21.718  1.00 59.12  ? 224 VAL C O   1 
ATOM   9544  C CB  . VAL C 1 224 ? 27.348  72.804  20.230  1.00 61.96  ? 224 VAL C CB  1 
ATOM   9545  C CG1 . VAL C 1 224 ? 26.116  73.489  20.817  1.00 63.68  ? 224 VAL C CG1 1 
ATOM   9546  C CG2 . VAL C 1 224 ? 27.062  72.395  18.787  1.00 63.65  ? 224 VAL C CG2 1 
ATOM   9547  N N   . ASN C 1 225 ? 29.447  73.937  22.629  1.00 62.69  ? 225 ASN C N   1 
ATOM   9548  C CA  . ASN C 1 225 ? 29.552  74.598  23.927  1.00 65.11  ? 225 ASN C CA  1 
ATOM   9549  C C   . ASN C 1 225 ? 30.799  75.479  24.042  1.00 63.87  ? 225 ASN C C   1 
ATOM   9550  O O   . ASN C 1 225 ? 31.241  75.771  25.151  1.00 66.28  ? 225 ASN C O   1 
ATOM   9551  C CB  . ASN C 1 225 ? 29.582  73.583  25.063  1.00 69.17  ? 225 ASN C CB  1 
ATOM   9552  C CG  . ASN C 1 225 ? 30.789  72.677  24.984  1.00 68.34  ? 225 ASN C CG  1 
ATOM   9553  O OD1 . ASN C 1 225 ? 31.529  72.697  23.985  1.00 61.74  ? 225 ASN C OD1 1 
ATOM   9554  N ND2 . ASN C 1 225 ? 30.978  71.863  26.013  1.00 62.60  ? 225 ASN C ND2 1 
ATOM   9555  N N   . THR C 1 226 ? 31.376  75.904  22.912  1.00 68.07  ? 226 THR C N   1 
ATOM   9556  C CA  . THR C 1 226 ? 32.507  76.817  22.954  1.00 68.31  ? 226 THR C CA  1 
ATOM   9557  C C   . THR C 1 226 ? 32.053  78.064  23.708  1.00 67.73  ? 226 THR C C   1 
ATOM   9558  O O   . THR C 1 226 ? 30.933  78.524  23.494  1.00 58.26  ? 226 THR C O   1 
ATOM   9559  C CB  . THR C 1 226 ? 33.014  77.182  21.556  1.00 69.90  ? 226 THR C CB  1 
ATOM   9560  O OG1 . THR C 1 226 ? 33.332  76.004  20.822  1.00 71.18  ? 226 THR C OG1 1 
ATOM   9561  C CG2 . THR C 1 226 ? 34.265  78.042  21.606  1.00 70.10  ? 226 THR C CG2 1 
ATOM   9562  N N   . PRO C 1 227 ? 32.899  78.640  24.598  1.00 73.95  ? 227 PRO C N   1 
ATOM   9563  C CA  . PRO C 1 227 ? 32.584  79.913  25.255  1.00 70.63  ? 227 PRO C CA  1 
ATOM   9564  C C   . PRO C 1 227 ? 32.254  81.016  24.248  1.00 61.94  ? 227 PRO C C   1 
ATOM   9565  O O   . PRO C 1 227 ? 32.995  81.201  23.278  1.00 59.53  ? 227 PRO C O   1 
ATOM   9566  C CB  . PRO C 1 227 ? 33.862  80.222  26.060  1.00 71.76  ? 227 PRO C CB  1 
ATOM   9567  C CG  . PRO C 1 227 ? 34.497  78.867  26.284  1.00 72.29  ? 227 PRO C CG  1 
ATOM   9568  C CD  . PRO C 1 227 ? 34.209  78.100  25.010  1.00 74.41  ? 227 PRO C CD  1 
ATOM   9569  N N   . GLY C 1 228 ? 31.118  81.701  24.475  1.00 52.37  ? 228 GLY C N   1 
ATOM   9570  C CA  . GLY C 1 228 ? 30.682  82.812  23.639  1.00 57.99  ? 228 GLY C CA  1 
ATOM   9571  C C   . GLY C 1 228 ? 29.717  82.422  22.505  1.00 61.07  ? 228 GLY C C   1 
ATOM   9572  O O   . GLY C 1 228 ? 29.151  83.326  21.879  1.00 56.57  ? 228 GLY C O   1 
ATOM   9573  N N   . LEU C 1 229 ? 29.526  81.109  22.235  1.00 60.35  ? 229 LEU C N   1 
ATOM   9574  C CA  . LEU C 1 229 ? 28.616  80.637  21.188  1.00 59.59  ? 229 LEU C CA  1 
ATOM   9575  C C   . LEU C 1 229 ? 27.189  80.506  21.730  1.00 52.39  ? 229 LEU C C   1 
ATOM   9576  O O   . LEU C 1 229 ? 26.954  79.790  22.694  1.00 52.76  ? 229 LEU C O   1 
ATOM   9577  C CB  . LEU C 1 229 ? 29.080  79.307  20.593  1.00 58.43  ? 229 LEU C CB  1 
ATOM   9578  C CG  . LEU C 1 229 ? 28.235  78.768  19.431  1.00 62.47  ? 229 LEU C CG  1 
ATOM   9579  C CD1 . LEU C 1 229 ? 28.153  79.769  18.284  1.00 64.65  ? 229 LEU C CD1 1 
ATOM   9580  C CD2 . LEU C 1 229 ? 28.779  77.454  18.914  1.00 62.27  ? 229 LEU C CD2 1 
ATOM   9581  N N   . SER C 1 230 ? 26.229  81.192  21.102  1.00 52.78  ? 230 SER C N   1 
ATOM   9582  C CA  . SER C 1 230 ? 24.820  81.073  21.473  1.00 55.90  ? 230 SER C CA  1 
ATOM   9583  C C   . SER C 1 230 ? 24.011  80.535  20.290  1.00 54.09  ? 230 SER C C   1 
ATOM   9584  O O   . SER C 1 230 ? 24.121  81.055  19.173  1.00 51.66  ? 230 SER C O   1 
ATOM   9585  C CB  . SER C 1 230 ? 24.255  82.398  21.940  1.00 56.78  ? 230 SER C CB  1 
ATOM   9586  O OG  . SER C 1 230 ? 24.699  82.721  23.249  1.00 62.06  ? 230 SER C OG  1 
ATOM   9587  N N   . LEU C 1 231 ? 23.207  79.495  20.551  1.00 53.25  ? 231 LEU C N   1 
ATOM   9588  C CA  . LEU C 1 231 ? 22.312  78.912  19.560  1.00 53.74  ? 231 LEU C CA  1 
ATOM   9589  C C   . LEU C 1 231 ? 20.903  79.487  19.726  1.00 54.10  ? 231 LEU C C   1 
ATOM   9590  O O   . LEU C 1 231 ? 20.245  79.257  20.741  1.00 50.19  ? 231 LEU C O   1 
ATOM   9591  C CB  . LEU C 1 231 ? 22.320  77.393  19.717  1.00 56.49  ? 231 LEU C CB  1 
ATOM   9592  C CG  . LEU C 1 231 ? 23.681  76.706  19.551  1.00 63.57  ? 231 LEU C CG  1 
ATOM   9593  C CD1 . LEU C 1 231 ? 23.495  75.199  19.488  1.00 69.25  ? 231 LEU C CD1 1 
ATOM   9594  C CD2 . LEU C 1 231 ? 24.460  77.189  18.339  1.00 60.70  ? 231 LEU C CD2 1 
ATOM   9595  N N   . VAL C 1 232 ? 20.439  80.226  18.708  1.00 52.87  ? 232 VAL C N   1 
ATOM   9596  C CA  . VAL C 1 232 ? 19.146  80.887  18.783  1.00 56.32  ? 232 VAL C CA  1 
ATOM   9597  C C   . VAL C 1 232 ? 18.164  80.152  17.866  1.00 54.00  ? 232 VAL C C   1 
ATOM   9598  O O   . VAL C 1 232 ? 18.091  80.422  16.666  1.00 46.83  ? 232 VAL C O   1 
ATOM   9599  C CB  . VAL C 1 232 ? 19.260  82.394  18.470  1.00 53.50  ? 232 VAL C CB  1 
ATOM   9600  C CG1 . VAL C 1 232 ? 17.933  83.121  18.656  1.00 48.08  ? 232 VAL C CG1 1 
ATOM   9601  C CG2 . VAL C 1 232 ? 20.338  83.037  19.329  1.00 52.10  ? 232 VAL C CG2 1 
ATOM   9602  N N   . CYS C 1 233 ? 17.383  79.242  18.471  1.00 51.38  ? 233 CYS C N   1 
ATOM   9603  C CA  . CYS C 1 233 ? 16.527  78.343  17.719  1.00 53.42  ? 233 CYS C CA  1 
ATOM   9604  C C   . CYS C 1 233 ? 15.097  78.881  17.693  1.00 49.55  ? 233 CYS C C   1 
ATOM   9605  O O   . CYS C 1 233 ? 14.665  79.572  18.613  1.00 50.68  ? 233 CYS C O   1 
ATOM   9606  C CB  . CYS C 1 233 ? 16.614  76.911  18.257  1.00 50.23  ? 233 CYS C CB  1 
ATOM   9607  S SG  . CYS C 1 233 ? 18.307  76.267  18.227  1.00 54.28  ? 233 CYS C SG  1 
ATOM   9608  N N   . ARG C 1 234 ? 14.386  78.524  16.613  1.00 46.28  ? 234 ARG C N   1 
ATOM   9609  C CA  . ARG C 1 234 ? 12.958  78.736  16.472  1.00 43.70  ? 234 ARG C CA  1 
ATOM   9610  C C   . ARG C 1 234 ? 12.234  78.016  17.606  1.00 44.33  ? 234 ARG C C   1 
ATOM   9611  O O   . ARG C 1 234 ? 12.783  77.103  18.230  1.00 53.16  ? 234 ARG C O   1 
ATOM   9612  C CB  . ARG C 1 234 ? 12.502  78.273  15.074  1.00 44.04  ? 234 ARG C CB  1 
ATOM   9613  C CG  . ARG C 1 234 ? 12.498  76.760  14.873  1.00 45.67  ? 234 ARG C CG  1 
ATOM   9614  C CD  . ARG C 1 234 ? 12.057  76.362  13.477  1.00 47.86  ? 234 ARG C CD  1 
ATOM   9615  N NE  . ARG C 1 234 ? 12.124  74.912  13.230  1.00 53.05  ? 234 ARG C NE  1 
ATOM   9616  C CZ  . ARG C 1 234 ? 11.351  73.957  13.787  1.00 50.79  ? 234 ARG C CZ  1 
ATOM   9617  N NH1 . ARG C 1 234 ? 10.418  74.252  14.693  1.00 49.67  ? 234 ARG C NH1 1 
ATOM   9618  N NH2 . ARG C 1 234 ? 11.543  72.684  13.458  1.00 45.48  ? 234 ARG C NH2 1 
ATOM   9619  N N   . GLN C 1 235 ? 10.973  78.407  17.830  1.00 44.94  ? 235 GLN C N   1 
ATOM   9620  C CA  . GLN C 1 235 ? 10.141  77.768  18.838  1.00 46.53  ? 235 GLN C CA  1 
ATOM   9621  C C   . GLN C 1 235 ? 9.969   76.279  18.501  1.00 45.27  ? 235 GLN C C   1 
ATOM   9622  O O   . GLN C 1 235 ? 9.930   75.903  17.329  1.00 46.73  ? 235 GLN C O   1 
ATOM   9623  C CB  . GLN C 1 235 ? 8.801   78.512  18.855  1.00 46.46  ? 235 GLN C CB  1 
ATOM   9624  C CG  . GLN C 1 235 ? 7.798   77.974  19.871  1.00 46.50  ? 235 GLN C CG  1 
ATOM   9625  C CD  . GLN C 1 235 ? 8.340   78.039  21.282  1.00 47.70  ? 235 GLN C CD  1 
ATOM   9626  O OE1 . GLN C 1 235 ? 9.214   77.267  21.677  1.00 45.60  ? 235 GLN C OE1 1 
ATOM   9627  N NE2 . GLN C 1 235 ? 7.875   79.014  22.045  1.00 52.12  ? 235 GLN C NE2 1 
ATOM   9628  N N   . SER C 1 236 ? 9.841   75.431  19.526  1.00 45.80  ? 236 SER C N   1 
ATOM   9629  C CA  . SER C 1 236 ? 9.493   74.035  19.306  1.00 47.99  ? 236 SER C CA  1 
ATOM   9630  C C   . SER C 1 236 ? 7.991   73.895  19.031  1.00 55.97  ? 236 SER C C   1 
ATOM   9631  O O   . SER C 1 236 ? 7.156   74.502  19.707  1.00 49.17  ? 236 SER C O   1 
ATOM   9632  C CB  . SER C 1 236 ? 9.899   73.162  20.457  1.00 49.10  ? 236 SER C CB  1 
ATOM   9633  O OG  . SER C 1 236 ? 9.590   71.802  20.176  1.00 47.69  ? 236 SER C OG  1 
ATOM   9634  N N   . ASN C 1 237 ? 7.673   73.070  18.024  1.00 51.90  ? 237 ASN C N   1 
ATOM   9635  C CA  . ASN C 1 237 ? 6.331   72.594  17.761  1.00 47.40  ? 237 ASN C CA  1 
ATOM   9636  C C   . ASN C 1 237 ? 6.170   71.177  18.321  1.00 52.63  ? 237 ASN C C   1 
ATOM   9637  O O   . ASN C 1 237 ? 5.198   70.494  18.000  1.00 51.48  ? 237 ASN C O   1 
ATOM   9638  C CB  . ASN C 1 237 ? 6.071   72.648  16.262  1.00 48.47  ? 237 ASN C CB  1 
ATOM   9639  C CG  . ASN C 1 237 ? 6.206   74.054  15.710  1.00 44.98  ? 237 ASN C CG  1 
ATOM   9640  O OD1 . ASN C 1 237 ? 5.477   74.946  16.135  1.00 46.19  ? 237 ASN C OD1 1 
ATOM   9641  N ND2 . ASN C 1 237 ? 7.089   74.278  14.751  1.00 41.06  ? 237 ASN C ND2 1 
ATOM   9642  N N   . ALA C 1 238 ? 7.116   70.706  19.152  1.00 51.17  ? 238 ALA C N   1 
ATOM   9643  C CA  . ALA C 1 238 ? 6.948   69.395  19.778  1.00 56.66  ? 238 ALA C CA  1 
ATOM   9644  C C   . ALA C 1 238 ? 5.714   69.442  20.679  1.00 53.80  ? 238 ALA C C   1 
ATOM   9645  O O   . ALA C 1 238 ? 5.405   70.495  21.243  1.00 53.36  ? 238 ALA C O   1 
ATOM   9646  C CB  . ALA C 1 238 ? 8.187   68.971  20.548  1.00 50.16  ? 238 ALA C CB  1 
ATOM   9647  N N   . THR C 1 239 ? 4.988   68.323  20.761  1.00 50.59  ? 239 THR C N   1 
ATOM   9648  C CA  . THR C 1 239 ? 3.827   68.229  21.637  1.00 54.24  ? 239 THR C CA  1 
ATOM   9649  C C   . THR C 1 239 ? 3.963   66.954  22.467  1.00 57.58  ? 239 THR C C   1 
ATOM   9650  O O   . THR C 1 239 ? 3.176   66.024  22.305  1.00 65.59  ? 239 THR C O   1 
ATOM   9651  C CB  . THR C 1 239 ? 2.514   68.291  20.837  1.00 53.41  ? 239 THR C CB  1 
ATOM   9652  O OG1 . THR C 1 239 ? 2.461   67.231  19.880  1.00 47.71  ? 239 THR C OG1 1 
ATOM   9653  C CG2 . THR C 1 239 ? 2.309   69.614  20.110  1.00 47.87  ? 239 THR C CG2 1 
ATOM   9654  N N   . PRO C 1 240 ? 4.944   66.877  23.401  1.00 63.13  ? 240 PRO C N   1 
ATOM   9655  C CA  . PRO C 1 240 ? 5.175   65.652  24.183  1.00 63.67  ? 240 PRO C CA  1 
ATOM   9656  C C   . PRO C 1 240 ? 3.995   65.151  25.023  1.00 63.84  ? 240 PRO C C   1 
ATOM   9657  O O   . PRO C 1 240 ? 3.917   63.965  25.321  1.00 68.78  ? 240 PRO C O   1 
ATOM   9658  C CB  . PRO C 1 240 ? 6.382   66.033  25.072  1.00 63.20  ? 240 PRO C CB  1 
ATOM   9659  C CG  . PRO C 1 240 ? 6.283   67.551  25.182  1.00 68.88  ? 240 PRO C CG  1 
ATOM   9660  C CD  . PRO C 1 240 ? 5.827   67.987  23.804  1.00 63.87  ? 240 PRO C CD  1 
ATOM   9661  N N   . ASP C 1 241 ? 3.068   66.048  25.392  1.00 65.78  ? 241 ASP C N   1 
ATOM   9662  C CA  . ASP C 1 241 ? 1.958   65.697  26.266  1.00 67.31  ? 241 ASP C CA  1 
ATOM   9663  C C   . ASP C 1 241 ? 0.676   65.451  25.483  1.00 66.06  ? 241 ASP C C   1 
ATOM   9664  O O   . ASP C 1 241 ? -0.303  65.038  26.084  1.00 62.31  ? 241 ASP C O   1 
ATOM   9665  C CB  . ASP C 1 241 ? 1.626   66.789  27.278  1.00 72.43  ? 241 ASP C CB  1 
ATOM   9666  C CG  . ASP C 1 241 ? 2.717   67.105  28.290  1.00 77.34  ? 241 ASP C CG  1 
ATOM   9667  O OD1 . ASP C 1 241 ? 3.414   66.142  28.708  1.00 73.96  ? 241 ASP C OD1 1 
ATOM   9668  O OD2 . ASP C 1 241 ? 2.836   68.302  28.671  1.00 72.79  ? 241 ASP C OD2 1 
ATOM   9669  N N   . ALA C 1 242 ? 0.644   65.751  24.177  1.00 63.52  ? 242 ALA C N   1 
ATOM   9670  C CA  . ALA C 1 242 ? -0.545  65.453  23.397  1.00 59.69  ? 242 ALA C CA  1 
ATOM   9671  C C   . ALA C 1 242 ? -0.701  63.935  23.268  1.00 64.35  ? 242 ALA C C   1 
ATOM   9672  O O   . ALA C 1 242 ? 0.241   63.171  23.510  1.00 59.29  ? 242 ALA C O   1 
ATOM   9673  C CB  . ALA C 1 242 ? -0.502  66.138  22.052  1.00 52.11  ? 242 ALA C CB  1 
ATOM   9674  N N   . ASP C 1 243 ? -1.927  63.527  22.927  1.00 65.59  ? 243 ASP C N   1 
ATOM   9675  C CA  . ASP C 1 243 ? -2.259  62.149  22.602  1.00 69.87  ? 243 ASP C CA  1 
ATOM   9676  C C   . ASP C 1 243 ? -1.763  61.813  21.187  1.00 70.74  ? 243 ASP C C   1 
ATOM   9677  O O   . ASP C 1 243 ? -2.076  62.518  20.218  1.00 52.89  ? 243 ASP C O   1 
ATOM   9678  C CB  . ASP C 1 243 ? -3.756  61.904  22.761  1.00 64.23  ? 243 ASP C CB  1 
ATOM   9679  C CG  . ASP C 1 243 ? -4.185  60.448  22.697  1.00 64.32  ? 243 ASP C CG  1 
ATOM   9680  O OD1 . ASP C 1 243 ? -3.729  59.749  21.763  1.00 57.79  ? 243 ASP C OD1 1 
ATOM   9681  O OD2 . ASP C 1 243 ? -4.988  60.036  23.569  1.00 73.44  ? 243 ASP C OD2 1 
ATOM   9682  N N   . PRO C 1 244 ? -1.007  60.698  21.025  1.00 66.98  ? 244 PRO C N   1 
ATOM   9683  C CA  . PRO C 1 244 ? -0.482  60.276  19.720  1.00 55.20  ? 244 PRO C CA  1 
ATOM   9684  C C   . PRO C 1 244 ? -1.516  60.066  18.618  1.00 54.44  ? 244 PRO C C   1 
ATOM   9685  O O   . PRO C 1 244 ? -1.224  60.245  17.428  1.00 48.93  ? 244 PRO C O   1 
ATOM   9686  C CB  . PRO C 1 244 ? 0.215   58.959  20.072  1.00 63.42  ? 244 PRO C CB  1 
ATOM   9687  C CG  . PRO C 1 244 ? 0.615   59.125  21.513  1.00 64.68  ? 244 PRO C CG  1 
ATOM   9688  C CD  . PRO C 1 244 ? -0.589  59.805  22.122  1.00 64.07  ? 244 PRO C CD  1 
ATOM   9689  N N   . TYR C 1 245 ? -2.736  59.682  19.009  1.00 48.52  ? 245 TYR C N   1 
ATOM   9690  C CA  . TYR C 1 245 ? -3.817  59.586  18.038  1.00 46.58  ? 245 TYR C CA  1 
ATOM   9691  C C   . TYR C 1 245 ? -4.119  60.966  17.436  1.00 49.61  ? 245 TYR C C   1 
ATOM   9692  O O   . TYR C 1 245 ? -4.367  61.082  16.237  1.00 51.94  ? 245 TYR C O   1 
ATOM   9693  C CB  . TYR C 1 245 ? -5.058  58.958  18.678  1.00 47.67  ? 245 TYR C CB  1 
ATOM   9694  C CG  . TYR C 1 245 ? -6.160  58.782  17.655  1.00 48.49  ? 245 TYR C CG  1 
ATOM   9695  C CD1 . TYR C 1 245 ? -6.257  57.623  16.883  1.00 47.62  ? 245 TYR C CD1 1 
ATOM   9696  C CD2 . TYR C 1 245 ? -7.051  59.811  17.413  1.00 45.12  ? 245 TYR C CD2 1 
ATOM   9697  C CE1 . TYR C 1 245 ? -7.249  57.487  15.927  1.00 47.55  ? 245 TYR C CE1 1 
ATOM   9698  C CE2 . TYR C 1 245 ? -8.038  59.690  16.451  1.00 53.91  ? 245 TYR C CE2 1 
ATOM   9699  C CZ  . TYR C 1 245 ? -8.138  58.527  15.704  1.00 51.22  ? 245 TYR C CZ  1 
ATOM   9700  O OH  . TYR C 1 245 ? -9.144  58.454  14.779  1.00 50.71  ? 245 TYR C OH  1 
ATOM   9701  N N   . ASP C 1 246 ? -4.119  62.006  18.282  1.00 50.28  ? 246 ASP C N   1 
ATOM   9702  C CA  . ASP C 1 246 ? -4.483  63.349  17.874  1.00 53.01  ? 246 ASP C CA  1 
ATOM   9703  C C   . ASP C 1 246 ? -3.354  63.944  17.037  1.00 54.74  ? 246 ASP C C   1 
ATOM   9704  O O   . ASP C 1 246 ? -3.620  64.454  15.949  1.00 51.47  ? 246 ASP C O   1 
ATOM   9705  C CB  . ASP C 1 246 ? -4.818  64.213  19.083  1.00 61.46  ? 246 ASP C CB  1 
ATOM   9706  C CG  . ASP C 1 246 ? -6.037  63.779  19.888  1.00 59.78  ? 246 ASP C CG  1 
ATOM   9707  O OD1 . ASP C 1 246 ? -6.882  63.071  19.309  1.00 60.38  ? 246 ASP C OD1 1 
ATOM   9708  O OD2 . ASP C 1 246 ? -6.121  64.129  21.092  1.00 59.60  ? 246 ASP C OD2 1 
ATOM   9709  N N   . HIS C 1 247 ? -2.115  63.846  17.553  1.00 50.24  ? 247 HIS C N   1 
ATOM   9710  C CA  . HIS C 1 247 ? -0.925  64.373  16.897  1.00 59.46  ? 247 HIS C CA  1 
ATOM   9711  C C   . HIS C 1 247 ? 0.136   63.268  16.799  1.00 59.51  ? 247 HIS C C   1 
ATOM   9712  O O   . HIS C 1 247 ? 1.010   63.186  17.665  1.00 48.50  ? 247 HIS C O   1 
ATOM   9713  C CB  . HIS C 1 247 ? -0.444  65.662  17.586  1.00 62.45  ? 247 HIS C CB  1 
ATOM   9714  C CG  . HIS C 1 247 ? -1.408  66.807  17.426  1.00 70.31  ? 247 HIS C CG  1 
ATOM   9715  N ND1 . HIS C 1 247 ? -1.679  67.385  16.199  1.00 78.16  ? 247 HIS C ND1 1 
ATOM   9716  C CD2 . HIS C 1 247 ? -2.217  67.418  18.301  1.00 63.65  ? 247 HIS C CD2 1 
ATOM   9717  C CE1 . HIS C 1 247 ? -2.598  68.329  16.344  1.00 69.95  ? 247 HIS C CE1 1 
ATOM   9718  N NE2 . HIS C 1 247 ? -2.927  68.372  17.615  1.00 71.09  ? 247 HIS C NE2 1 
ATOM   9719  N N   . PRO C 1 248 ? 0.094   62.401  15.742  1.00 54.25  ? 248 PRO C N   1 
ATOM   9720  C CA  . PRO C 1 248 ? 0.983   61.237  15.630  1.00 51.57  ? 248 PRO C CA  1 
ATOM   9721  C C   . PRO C 1 248 ? 2.462   61.516  15.428  1.00 50.95  ? 248 PRO C C   1 
ATOM   9722  O O   . PRO C 1 248 ? 3.264   60.608  15.636  1.00 52.26  ? 248 PRO C O   1 
ATOM   9723  C CB  . PRO C 1 248 ? 0.425   60.478  14.407  1.00 50.02  ? 248 PRO C CB  1 
ATOM   9724  C CG  . PRO C 1 248 ? -0.197  61.571  13.576  1.00 52.64  ? 248 PRO C CG  1 
ATOM   9725  C CD  . PRO C 1 248 ? -0.849  62.472  14.610  1.00 51.36  ? 248 PRO C CD  1 
ATOM   9726  N N   . LEU C 1 249 ? 2.805   62.741  15.002  1.00 47.50  ? 249 LEU C N   1 
ATOM   9727  C CA  . LEU C 1 249 ? 4.177   63.056  14.624  1.00 50.01  ? 249 LEU C CA  1 
ATOM   9728  C C   . LEU C 1 249 ? 4.787   64.104  15.563  1.00 52.91  ? 249 LEU C C   1 
ATOM   9729  O O   . LEU C 1 249 ? 5.951   63.955  15.948  1.00 50.54  ? 249 LEU C O   1 
ATOM   9730  C CB  . LEU C 1 249 ? 4.272   63.469  13.151  1.00 52.82  ? 249 LEU C CB  1 
ATOM   9731  C CG  . LEU C 1 249 ? 3.752   62.453  12.116  1.00 58.80  ? 249 LEU C CG  1 
ATOM   9732  C CD1 . LEU C 1 249 ? 3.855   62.978  10.687  1.00 55.56  ? 249 LEU C CD1 1 
ATOM   9733  C CD2 . LEU C 1 249 ? 4.447   61.081  12.200  1.00 58.16  ? 249 LEU C CD2 1 
ATOM   9734  N N   . SER C 1 250 ? 4.028   65.151  15.941  1.00 49.27  ? 250 SER C N   1 
ATOM   9735  C CA  . SER C 1 250 ? 4.555   66.192  16.824  1.00 48.25  ? 250 SER C CA  1 
ATOM   9736  C C   . SER C 1 250 ? 4.809   65.656  18.231  1.00 45.37  ? 250 SER C C   1 
ATOM   9737  O O   . SER C 1 250 ? 5.568   66.249  18.991  1.00 45.45  ? 250 SER C O   1 
ATOM   9738  C CB  . SER C 1 250 ? 3.672   67.437  16.882  1.00 50.29  ? 250 SER C CB  1 
ATOM   9739  O OG  . SER C 1 250 ? 2.398   67.180  17.463  1.00 48.90  ? 250 SER C OG  1 
ATOM   9740  N N   . THR C 1 251 ? 4.166   64.538  18.576  1.00 50.94  ? 251 THR C N   1 
ATOM   9741  C CA  . THR C 1 251 ? 4.437   63.829  19.817  1.00 54.72  ? 251 THR C CA  1 
ATOM   9742  C C   . THR C 1 251 ? 5.841   63.210  19.820  1.00 49.94  ? 251 THR C C   1 
ATOM   9743  O O   . THR C 1 251 ? 6.382   62.988  20.894  1.00 49.30  ? 251 THR C O   1 
ATOM   9744  C CB  . THR C 1 251 ? 3.357   62.771  20.045  1.00 54.87  ? 251 THR C CB  1 
ATOM   9745  O OG1 . THR C 1 251 ? 3.158   62.158  18.775  1.00 63.32  ? 251 THR C OG1 1 
ATOM   9746  C CG2 . THR C 1 251 ? 2.045   63.347  20.536  1.00 53.71  ? 251 THR C CG2 1 
ATOM   9747  N N   . ILE C 1 252 ? 6.426   62.916  18.650  1.00 49.13  ? 252 ILE C N   1 
ATOM   9748  C CA  . ILE C 1 252 ? 7.740   62.283  18.590  1.00 53.87  ? 252 ILE C CA  1 
ATOM   9749  C C   . ILE C 1 252 ? 8.790   63.323  18.939  1.00 49.66  ? 252 ILE C C   1 
ATOM   9750  O O   . ILE C 1 252 ? 9.701   63.057  19.702  1.00 52.62  ? 252 ILE C O   1 
ATOM   9751  C CB  . ILE C 1 252 ? 8.045   61.643  17.215  1.00 57.41  ? 252 ILE C CB  1 
ATOM   9752  C CG1 . ILE C 1 252 ? 6.992   60.609  16.781  1.00 59.06  ? 252 ILE C CG1 1 
ATOM   9753  C CG2 . ILE C 1 252 ? 9.446   61.029  17.199  1.00 55.65  ? 252 ILE C CG2 1 
ATOM   9754  C CD1 . ILE C 1 252 ? 7.160   60.110  15.352  1.00 57.56  ? 252 ILE C CD1 1 
ATOM   9755  N N   . GLY C 1 253 ? 8.664   64.510  18.353  1.00 54.03  ? 253 GLY C N   1 
ATOM   9756  C CA  . GLY C 1 253 ? 9.709   65.509  18.485  1.00 52.27  ? 253 GLY C CA  1 
ATOM   9757  C C   . GLY C 1 253 ? 9.674   66.493  17.323  1.00 51.45  ? 253 GLY C C   1 
ATOM   9758  O O   . GLY C 1 253 ? 8.851   66.340  16.418  1.00 51.89  ? 253 GLY C O   1 
ATOM   9759  N N   . ASP C 1 254 ? 10.571  67.492  17.409  1.00 50.09  ? 254 ASP C N   1 
ATOM   9760  C CA  . ASP C 1 254 ? 10.715  68.578  16.455  1.00 47.16  ? 254 ASP C CA  1 
ATOM   9761  C C   . ASP C 1 254 ? 12.209  68.823  16.216  1.00 50.03  ? 254 ASP C C   1 
ATOM   9762  O O   . ASP C 1 254 ? 12.936  69.181  17.143  1.00 51.02  ? 254 ASP C O   1 
ATOM   9763  C CB  . ASP C 1 254 ? 10.030  69.849  16.953  1.00 48.33  ? 254 ASP C CB  1 
ATOM   9764  C CG  . ASP C 1 254 ? 9.862   70.942  15.899  1.00 51.43  ? 254 ASP C CG  1 
ATOM   9765  O OD1 . ASP C 1 254 ? 10.217  70.672  14.734  1.00 48.65  ? 254 ASP C OD1 1 
ATOM   9766  O OD2 . ASP C 1 254 ? 9.398   72.068  16.237  1.00 49.52  ? 254 ASP C OD2 1 
ATOM   9767  N N   . GLU C 1 255 ? 12.651  68.635  14.962  1.00 49.59  ? 255 GLU C N   1 
ATOM   9768  C CA  . GLU C 1 255 ? 14.011  68.924  14.520  1.00 48.85  ? 255 GLU C CA  1 
ATOM   9769  C C   . GLU C 1 255 ? 14.245  70.431  14.348  1.00 51.44  ? 255 GLU C C   1 
ATOM   9770  O O   . GLU C 1 255 ? 14.068  70.984  13.255  1.00 48.61  ? 255 GLU C O   1 
ATOM   9771  C CB  . GLU C 1 255 ? 14.217  68.162  13.213  1.00 48.80  ? 255 GLU C CB  1 
ATOM   9772  C CG  . GLU C 1 255 ? 15.649  68.193  12.690  1.00 59.46  ? 255 GLU C CG  1 
ATOM   9773  C CD  . GLU C 1 255 ? 15.819  67.329  11.451  1.00 61.56  ? 255 GLU C CD  1 
ATOM   9774  O OE1 . GLU C 1 255 ? 15.223  67.726  10.418  1.00 59.61  ? 255 GLU C OE1 1 
ATOM   9775  O OE2 . GLU C 1 255 ? 16.495  66.266  11.523  1.00 58.91  ? 255 GLU C OE2 1 
ATOM   9776  N N   . LEU C 1 256 ? 14.731  71.083  15.415  1.00 50.29  ? 256 LEU C N   1 
ATOM   9777  C CA  . LEU C 1 256 ? 14.769  72.536  15.465  1.00 51.97  ? 256 LEU C CA  1 
ATOM   9778  C C   . LEU C 1 256 ? 15.851  73.090  14.538  1.00 52.32  ? 256 LEU C C   1 
ATOM   9779  O O   . LEU C 1 256 ? 16.909  72.490  14.381  1.00 60.24  ? 256 LEU C O   1 
ATOM   9780  C CB  . LEU C 1 256 ? 14.971  73.012  16.902  1.00 48.06  ? 256 LEU C CB  1 
ATOM   9781  C CG  . LEU C 1 256 ? 13.948  72.517  17.923  1.00 50.35  ? 256 LEU C CG  1 
ATOM   9782  C CD1 . LEU C 1 256 ? 14.236  73.138  19.272  1.00 52.40  ? 256 LEU C CD1 1 
ATOM   9783  C CD2 . LEU C 1 256 ? 12.500  72.773  17.529  1.00 50.48  ? 256 LEU C CD2 1 
ATOM   9784  N N   . ASP C 1 257 ? 15.540  74.246  13.937  1.00 52.58  ? 257 ASP C N   1 
ATOM   9785  C CA  . ASP C 1 257 ? 16.466  75.049  13.151  1.00 53.74  ? 257 ASP C CA  1 
ATOM   9786  C C   . ASP C 1 257 ? 16.792  76.313  13.934  1.00 52.44  ? 257 ASP C C   1 
ATOM   9787  O O   . ASP C 1 257 ? 16.027  76.688  14.827  1.00 45.15  ? 257 ASP C O   1 
ATOM   9788  C CB  . ASP C 1 257 ? 15.836  75.508  11.845  1.00 51.78  ? 257 ASP C CB  1 
ATOM   9789  C CG  . ASP C 1 257 ? 15.168  74.394  11.053  1.00 59.75  ? 257 ASP C CG  1 
ATOM   9790  O OD1 . ASP C 1 257 ? 15.928  73.581  10.458  1.00 61.90  ? 257 ASP C OD1 1 
ATOM   9791  O OD2 . ASP C 1 257 ? 13.903  74.313  11.096  1.00 51.85  ? 257 ASP C OD2 1 
ATOM   9792  N N   . GLY C 1 258 ? 17.893  76.988  13.567  1.00 56.94  ? 258 GLY C N   1 
ATOM   9793  C CA  . GLY C 1 258 ? 18.134  78.319  14.106  1.00 55.29  ? 258 GLY C CA  1 
ATOM   9794  C C   . GLY C 1 258 ? 19.400  78.994  13.590  1.00 48.19  ? 258 GLY C C   1 
ATOM   9795  O O   . GLY C 1 258 ? 20.047  78.544  12.653  1.00 48.92  ? 258 GLY C O   1 
ATOM   9796  N N   . MET C 1 259 ? 19.706  80.115  14.241  1.00 52.31  ? 259 MET C N   1 
ATOM   9797  C CA  . MET C 1 259 ? 20.888  80.922  13.998  1.00 51.62  ? 259 MET C CA  1 
ATOM   9798  C C   . MET C 1 259 ? 21.851  80.718  15.167  1.00 50.81  ? 259 MET C C   1 
ATOM   9799  O O   . MET C 1 259 ? 21.491  80.156  16.204  1.00 50.63  ? 259 MET C O   1 
ATOM   9800  C CB  . MET C 1 259 ? 20.512  82.408  13.899  1.00 58.48  ? 259 MET C CB  1 
ATOM   9801  C CG  . MET C 1 259 ? 19.129  82.687  13.292  1.00 60.94  ? 259 MET C CG  1 
ATOM   9802  S SD  . MET C 1 259 ? 18.594  84.413  13.312  1.00 60.87  ? 259 MET C SD  1 
ATOM   9803  C CE  . MET C 1 259 ? 20.069  85.181  12.629  1.00 62.75  ? 259 MET C CE  1 
ATOM   9804  N N   . ALA C 1 260 ? 23.086  81.179  14.989  1.00 52.25  ? 260 ALA C N   1 
ATOM   9805  C CA  . ALA C 1 260 ? 24.083  81.122  16.046  1.00 53.53  ? 260 ALA C CA  1 
ATOM   9806  C C   . ALA C 1 260 ? 24.794  82.468  16.141  1.00 55.25  ? 260 ALA C C   1 
ATOM   9807  O O   . ALA C 1 260 ? 25.127  83.051  15.105  1.00 52.13  ? 260 ALA C O   1 
ATOM   9808  C CB  . ALA C 1 260 ? 25.050  80.001  15.761  1.00 54.72  ? 260 ALA C CB  1 
ATOM   9809  N N   . TYR C 1 261 ? 24.982  82.968  17.378  1.00 60.28  ? 261 TYR C N   1 
ATOM   9810  C CA  . TYR C 1 261 ? 25.783  84.167  17.605  1.00 63.57  ? 261 TYR C CA  1 
ATOM   9811  C C   . TYR C 1 261 ? 27.138  83.775  18.216  1.00 62.12  ? 261 TYR C C   1 
ATOM   9812  O O   . TYR C 1 261 ? 27.194  83.064  19.226  1.00 54.63  ? 261 TYR C O   1 
ATOM   9813  C CB  . TYR C 1 261 ? 25.087  85.240  18.455  1.00 64.56  ? 261 TYR C CB  1 
ATOM   9814  C CG  . TYR C 1 261 ? 25.916  86.516  18.461  1.00 62.98  ? 261 TYR C CG  1 
ATOM   9815  C CD1 . TYR C 1 261 ? 25.993  87.318  17.324  1.00 67.01  ? 261 TYR C CD1 1 
ATOM   9816  C CD2 . TYR C 1 261 ? 26.683  86.878  19.563  1.00 61.04  ? 261 TYR C CD2 1 
ATOM   9817  C CE1 . TYR C 1 261 ? 26.784  88.457  17.289  1.00 68.74  ? 261 TYR C CE1 1 
ATOM   9818  C CE2 . TYR C 1 261 ? 27.464  88.026  19.551  1.00 60.11  ? 261 TYR C CE2 1 
ATOM   9819  C CZ  . TYR C 1 261 ? 27.521  88.816  18.409  1.00 69.05  ? 261 TYR C CZ  1 
ATOM   9820  O OH  . TYR C 1 261 ? 28.294  89.947  18.367  1.00 60.06  ? 261 TYR C OH  1 
ATOM   9821  N N   . PHE C 1 262 ? 28.219  84.245  17.568  1.00 55.85  ? 262 PHE C N   1 
ATOM   9822  C CA  . PHE C 1 262 ? 29.590  84.047  18.022  1.00 59.87  ? 262 PHE C CA  1 
ATOM   9823  C C   . PHE C 1 262 ? 30.107  85.348  18.659  1.00 64.45  ? 262 PHE C C   1 
ATOM   9824  O O   . PHE C 1 262 ? 30.446  86.311  17.962  1.00 53.06  ? 262 PHE C O   1 
ATOM   9825  C CB  . PHE C 1 262 ? 30.476  83.617  16.846  1.00 55.67  ? 262 PHE C CB  1 
ATOM   9826  C CG  . PHE C 1 262 ? 30.115  82.297  16.169  1.00 59.55  ? 262 PHE C CG  1 
ATOM   9827  C CD1 . PHE C 1 262 ? 28.974  82.177  15.382  1.00 55.01  ? 262 PHE C CD1 1 
ATOM   9828  C CD2 . PHE C 1 262 ? 30.948  81.186  16.275  1.00 56.02  ? 262 PHE C CD2 1 
ATOM   9829  C CE1 . PHE C 1 262 ? 28.661  80.973  14.768  1.00 58.15  ? 262 PHE C CE1 1 
ATOM   9830  C CE2 . PHE C 1 262 ? 30.626  79.989  15.654  1.00 56.74  ? 262 PHE C CE2 1 
ATOM   9831  C CZ  . PHE C 1 262 ? 29.483  79.882  14.907  1.00 52.56  ? 262 PHE C CZ  1 
ATOM   9832  N N   . ASP C 1 263 ? 30.153  85.362  20.000  1.00 59.61  ? 263 ASP C N   1 
ATOM   9833  C CA  . ASP C 1 263 ? 30.628  86.492  20.783  1.00 66.74  ? 263 ASP C CA  1 
ATOM   9834  C C   . ASP C 1 263 ? 32.126  86.349  21.085  1.00 65.55  ? 263 ASP C C   1 
ATOM   9835  O O   . ASP C 1 263 ? 32.496  85.769  22.108  1.00 62.95  ? 263 ASP C O   1 
ATOM   9836  C CB  . ASP C 1 263 ? 29.843  86.573  22.085  1.00 70.60  ? 263 ASP C CB  1 
ATOM   9837  C CG  . ASP C 1 263 ? 30.053  87.838  22.903  1.00 63.80  ? 263 ASP C CG  1 
ATOM   9838  O OD1 . ASP C 1 263 ? 30.526  88.839  22.330  1.00 63.59  ? 263 ASP C OD1 1 
ATOM   9839  O OD2 . ASP C 1 263 ? 29.730  87.811  24.099  1.00 63.91  ? 263 ASP C OD2 1 
ATOM   9840  N N   . ASP C 1 264 ? 32.976  86.895  20.198  1.00 68.34  ? 264 ASP C N   1 
ATOM   9841  C CA  . ASP C 1 264 ? 34.425  86.717  20.241  1.00 68.69  ? 264 ASP C CA  1 
ATOM   9842  C C   . ASP C 1 264 ? 34.772  85.253  20.524  1.00 67.00  ? 264 ASP C C   1 
ATOM   9843  O O   . ASP C 1 264 ? 35.515  84.954  21.450  1.00 65.30  ? 264 ASP C O   1 
ATOM   9844  C CB  . ASP C 1 264 ? 35.104  87.653  21.236  1.00 66.03  ? 264 ASP C CB  1 
ATOM   9845  C CG  . ASP C 1 264 ? 34.939  89.146  20.981  1.00 70.99  ? 264 ASP C CG  1 
ATOM   9846  O OD1 . ASP C 1 264 ? 34.845  89.542  19.800  1.00 68.73  ? 264 ASP C OD1 1 
ATOM   9847  O OD2 . ASP C 1 264 ? 34.943  89.913  21.967  1.00 79.75  ? 264 ASP C OD2 1 
ATOM   9848  N N   . VAL C 1 265 ? 34.233  84.332  19.720  1.00 71.93  ? 265 VAL C N   1 
ATOM   9849  C CA  . VAL C 1 265 ? 34.490  82.916  19.922  1.00 69.03  ? 265 VAL C CA  1 
ATOM   9850  C C   . VAL C 1 265 ? 35.911  82.626  19.457  1.00 66.45  ? 265 VAL C C   1 
ATOM   9851  O O   . VAL C 1 265 ? 36.338  83.157  18.436  1.00 62.59  ? 265 VAL C O   1 
ATOM   9852  C CB  . VAL C 1 265 ? 33.475  82.006  19.198  1.00 70.45  ? 265 VAL C CB  1 
ATOM   9853  C CG1 . VAL C 1 265 ? 33.960  80.556  19.102  1.00 67.13  ? 265 VAL C CG1 1 
ATOM   9854  C CG2 . VAL C 1 265 ? 32.101  82.069  19.854  1.00 69.29  ? 265 VAL C CG2 1 
ATOM   9855  N N   . PHE C 1 266 ? 36.606  81.756  20.204  1.00 67.91  ? 266 PHE C N   1 
ATOM   9856  C CA  . PHE C 1 266 ? 37.966  81.353  19.893  1.00 65.51  ? 266 PHE C CA  1 
ATOM   9857  C C   . PHE C 1 266 ? 37.931  80.014  19.163  1.00 59.87  ? 266 PHE C C   1 
ATOM   9858  O O   . PHE C 1 266 ? 37.238  79.093  19.577  1.00 64.19  ? 266 PHE C O   1 
ATOM   9859  C CB  . PHE C 1 266 ? 38.865  81.209  21.132  1.00 67.87  ? 266 PHE C CB  1 
ATOM   9860  C CG  . PHE C 1 266 ? 40.254  80.691  20.779  1.00 63.15  ? 266 PHE C CG  1 
ATOM   9861  C CD1 . PHE C 1 266 ? 41.180  81.519  20.146  1.00 62.57  ? 266 PHE C CD1 1 
ATOM   9862  C CD2 . PHE C 1 266 ? 40.609  79.368  21.025  1.00 60.73  ? 266 PHE C CD2 1 
ATOM   9863  C CE1 . PHE C 1 266 ? 42.436  81.042  19.795  1.00 63.06  ? 266 PHE C CE1 1 
ATOM   9864  C CE2 . PHE C 1 266 ? 41.869  78.900  20.686  1.00 62.26  ? 266 PHE C CE2 1 
ATOM   9865  C CZ  . PHE C 1 266 ? 42.778  79.734  20.069  1.00 60.74  ? 266 PHE C CZ  1 
ATOM   9866  N N   . ILE C 1 267 ? 38.718  79.917  18.090  1.00 59.80  ? 267 ILE C N   1 
ATOM   9867  C CA  . ILE C 1 267 ? 38.896  78.673  17.365  1.00 61.53  ? 267 ILE C CA  1 
ATOM   9868  C C   . ILE C 1 267 ? 40.401  78.401  17.272  1.00 64.60  ? 267 ILE C C   1 
ATOM   9869  O O   . ILE C 1 267 ? 41.171  79.240  16.787  1.00 60.88  ? 267 ILE C O   1 
ATOM   9870  C CB  . ILE C 1 267 ? 38.208  78.768  15.988  1.00 60.14  ? 267 ILE C CB  1 
ATOM   9871  C CG1 . ILE C 1 267 ? 36.712  79.096  16.130  1.00 60.26  ? 267 ILE C CG1 1 
ATOM   9872  C CG2 . ILE C 1 267 ? 38.429  77.505  15.151  1.00 60.20  ? 267 ILE C CG2 1 
ATOM   9873  C CD1 . ILE C 1 267 ? 36.015  79.442  14.821  1.00 63.76  ? 267 ILE C CD1 1 
ATOM   9874  N N   . PRO C 1 268 ? 40.881  77.248  17.792  1.00 58.67  ? 268 PRO C N   1 
ATOM   9875  C CA  . PRO C 1 268 ? 42.278  76.845  17.591  1.00 65.18  ? 268 PRO C CA  1 
ATOM   9876  C C   . PRO C 1 268 ? 42.590  76.499  16.134  1.00 65.61  ? 268 PRO C C   1 
ATOM   9877  O O   . PRO C 1 268 ? 41.713  76.077  15.389  1.00 60.87  ? 268 PRO C O   1 
ATOM   9878  C CB  . PRO C 1 268 ? 42.440  75.640  18.541  1.00 61.27  ? 268 PRO C CB  1 
ATOM   9879  C CG  . PRO C 1 268 ? 41.028  75.094  18.689  1.00 60.87  ? 268 PRO C CG  1 
ATOM   9880  C CD  . PRO C 1 268 ? 40.133  76.323  18.659  1.00 57.75  ? 268 PRO C CD  1 
ATOM   9881  N N   . TRP C 1 269 ? 43.850  76.685  15.726  1.00 70.48  ? 269 TRP C N   1 
ATOM   9882  C CA  . TRP C 1 269 ? 44.244  76.485  14.338  1.00 68.08  ? 269 TRP C CA  1 
ATOM   9883  C C   . TRP C 1 269 ? 43.921  75.064  13.882  1.00 67.59  ? 269 TRP C C   1 
ATOM   9884  O O   . TRP C 1 269 ? 43.566  74.859  12.718  1.00 61.45  ? 269 TRP C O   1 
ATOM   9885  C CB  . TRP C 1 269 ? 45.732  76.811  14.112  1.00 69.29  ? 269 TRP C CB  1 
ATOM   9886  C CG  . TRP C 1 269 ? 46.033  78.288  14.012  1.00 71.40  ? 269 TRP C CG  1 
ATOM   9887  C CD1 . TRP C 1 269 ? 46.811  79.014  14.866  1.00 66.64  ? 269 TRP C CD1 1 
ATOM   9888  C CD2 . TRP C 1 269 ? 45.544  79.224  13.015  1.00 70.14  ? 269 TRP C CD2 1 
ATOM   9889  N NE1 . TRP C 1 269 ? 46.831  80.330  14.482  1.00 74.84  ? 269 TRP C NE1 1 
ATOM   9890  C CE2 . TRP C 1 269 ? 46.079  80.490  13.347  1.00 67.60  ? 269 TRP C CE2 1 
ATOM   9891  C CE3 . TRP C 1 269 ? 44.730  79.118  11.876  1.00 64.21  ? 269 TRP C CE3 1 
ATOM   9892  C CZ2 . TRP C 1 269 ? 45.818  81.631  12.591  1.00 65.72  ? 269 TRP C CZ2 1 
ATOM   9893  C CZ3 . TRP C 1 269 ? 44.493  80.242  11.113  1.00 64.21  ? 269 TRP C CZ3 1 
ATOM   9894  C CH2 . TRP C 1 269 ? 45.025  81.482  11.473  1.00 65.50  ? 269 TRP C CH2 1 
ATOM   9895  N N   . GLU C 1 270 ? 44.034  74.098  14.806  1.00 68.96  ? 270 GLU C N   1 
ATOM   9896  C CA  . GLU C 1 270 ? 43.856  72.695  14.473  1.00 75.56  ? 270 GLU C CA  1 
ATOM   9897  C C   . GLU C 1 270 ? 42.447  72.483  13.912  1.00 79.05  ? 270 GLU C C   1 
ATOM   9898  O O   . GLU C 1 270 ? 42.231  71.517  13.182  1.00 73.25  ? 270 GLU C O   1 
ATOM   9899  C CB  . GLU C 1 270 ? 44.159  71.759  15.649  1.00 82.11  ? 270 GLU C CB  1 
ATOM   9900  C CG  . GLU C 1 270 ? 45.521  72.002  16.303  1.00 95.58  ? 270 GLU C CG  1 
ATOM   9901  C CD  . GLU C 1 270 ? 45.504  72.731  17.648  1.00 103.97 ? 270 GLU C CD  1 
ATOM   9902  O OE1 . GLU C 1 270 ? 45.752  73.960  17.660  1.00 86.95  ? 270 GLU C OE1 1 
ATOM   9903  O OE2 . GLU C 1 270 ? 45.273  72.071  18.694  1.00 101.08 ? 270 GLU C OE2 1 
ATOM   9904  N N   . ASN C 1 271 ? 41.519  73.401  14.240  1.00 71.18  ? 271 ASN C N   1 
ATOM   9905  C CA  . ASN C 1 271 ? 40.106  73.304  13.891  1.00 69.58  ? 271 ASN C CA  1 
ATOM   9906  C C   . ASN C 1 271 ? 39.735  74.101  12.639  1.00 70.24  ? 271 ASN C C   1 
ATOM   9907  O O   . ASN C 1 271 ? 38.577  74.084  12.220  1.00 69.04  ? 271 ASN C O   1 
ATOM   9908  C CB  . ASN C 1 271 ? 39.223  73.878  14.993  1.00 65.12  ? 271 ASN C CB  1 
ATOM   9909  C CG  . ASN C 1 271 ? 39.091  72.955  16.174  1.00 65.23  ? 271 ASN C CG  1 
ATOM   9910  O OD1 . ASN C 1 271 ? 39.495  71.786  16.110  1.00 65.53  ? 271 ASN C OD1 1 
ATOM   9911  N ND2 . ASN C 1 271 ? 38.499  73.465  17.243  1.00 66.71  ? 271 ASN C ND2 1 
ATOM   9912  N N   . VAL C 1 272 ? 40.686  74.848  12.080  1.00 64.39  ? 272 VAL C N   1 
ATOM   9913  C CA  . VAL C 1 272 ? 40.398  75.702  10.945  1.00 62.35  ? 272 VAL C CA  1 
ATOM   9914  C C   . VAL C 1 272 ? 40.704  74.892  9.692   1.00 64.47  ? 272 VAL C C   1 
ATOM   9915  O O   . VAL C 1 272 ? 41.695  74.172  9.671   1.00 66.01  ? 272 VAL C O   1 
ATOM   9916  C CB  . VAL C 1 272 ? 41.215  77.003  11.000  1.00 57.41  ? 272 VAL C CB  1 
ATOM   9917  C CG1 . VAL C 1 272 ? 40.846  77.952  9.870   1.00 60.93  ? 272 VAL C CG1 1 
ATOM   9918  C CG2 . VAL C 1 272 ? 41.077  77.703  12.344  1.00 59.90  ? 272 VAL C CG2 1 
ATOM   9919  N N   . GLN C 1 273 ? 39.830  75.006  8.680   1.00 66.75  ? 273 GLN C N   1 
ATOM   9920  C CA  . GLN C 1 273 ? 40.005  74.327  7.404   1.00 71.10  ? 273 GLN C CA  1 
ATOM   9921  C C   . GLN C 1 273 ? 40.379  75.309  6.289   1.00 73.96  ? 273 GLN C C   1 
ATOM   9922  O O   . GLN C 1 273 ? 41.034  74.917  5.323   1.00 73.50  ? 273 GLN C O   1 
ATOM   9923  C CB  . GLN C 1 273 ? 38.719  73.623  6.981   1.00 72.80  ? 273 GLN C CB  1 
ATOM   9924  C CG  . GLN C 1 273 ? 38.026  72.840  8.089   1.00 75.71  ? 273 GLN C CG  1 
ATOM   9925  C CD  . GLN C 1 273 ? 36.560  72.626  7.788   1.00 71.87  ? 273 GLN C CD  1 
ATOM   9926  O OE1 . GLN C 1 273 ? 35.870  73.526  7.288   1.00 68.10  ? 273 GLN C OE1 1 
ATOM   9927  N NE2 . GLN C 1 273 ? 36.081  71.421  8.061   1.00 76.20  ? 273 GLN C NE2 1 
ATOM   9928  N N   . HIS C 1 274 ? 39.924  76.565  6.400   1.00 75.33  ? 274 HIS C N   1 
ATOM   9929  C CA  . HIS C 1 274 ? 40.296  77.614  5.463   1.00 72.85  ? 274 HIS C CA  1 
ATOM   9930  C C   . HIS C 1 274 ? 39.854  78.976  5.999   1.00 73.57  ? 274 HIS C C   1 
ATOM   9931  O O   . HIS C 1 274 ? 38.834  79.071  6.678   1.00 78.47  ? 274 HIS C O   1 
ATOM   9932  C CB  . HIS C 1 274 ? 39.671  77.341  4.089   1.00 71.40  ? 274 HIS C CB  1 
ATOM   9933  C CG  . HIS C 1 274 ? 39.786  78.492  3.144   1.00 71.65  ? 274 HIS C CG  1 
ATOM   9934  N ND1 . HIS C 1 274 ? 40.733  78.549  2.141   1.00 73.04  ? 274 HIS C ND1 1 
ATOM   9935  C CD2 . HIS C 1 274 ? 39.071  79.636  3.055   1.00 72.18  ? 274 HIS C CD2 1 
ATOM   9936  C CE1 . HIS C 1 274 ? 40.586  79.692  1.473   1.00 74.65  ? 274 HIS C CE1 1 
ATOM   9937  N NE2 . HIS C 1 274 ? 39.593  80.374  2.023   1.00 74.83  ? 274 HIS C NE2 1 
ATOM   9938  N N   . ILE C 1 275 ? 40.638  80.020  5.684   1.00 78.77  ? 275 ILE C N   1 
ATOM   9939  C CA  . ILE C 1 275 ? 40.249  81.416  5.867   1.00 77.45  ? 275 ILE C CA  1 
ATOM   9940  C C   . ILE C 1 275 ? 40.819  82.233  4.705   1.00 77.76  ? 275 ILE C C   1 
ATOM   9941  O O   . ILE C 1 275 ? 41.770  81.802  4.058   1.00 81.52  ? 275 ILE C O   1 
ATOM   9942  C CB  . ILE C 1 275 ? 40.745  81.984  7.219   1.00 82.76  ? 275 ILE C CB  1 
ATOM   9943  C CG1 . ILE C 1 275 ? 42.285  81.845  7.389   1.00 78.55  ? 275 ILE C CG1 1 
ATOM   9944  C CG2 . ILE C 1 275 ? 39.986  81.375  8.403   1.00 77.18  ? 275 ILE C CG2 1 
ATOM   9945  C CD1 . ILE C 1 275 ? 42.885  82.751  8.451   1.00 74.37  ? 275 ILE C CD1 1 
ATOM   9946  N N   . GLY C 1 276 ? 40.257  83.422  4.452   1.00 77.89  ? 276 GLY C N   1 
ATOM   9947  C CA  . GLY C 1 276 ? 40.986  84.462  3.734   1.00 77.72  ? 276 GLY C CA  1 
ATOM   9948  C C   . GLY C 1 276 ? 40.507  84.741  2.305   1.00 76.32  ? 276 GLY C C   1 
ATOM   9949  O O   . GLY C 1 276 ? 40.502  85.893  1.883   1.00 77.03  ? 276 GLY C O   1 
ATOM   9950  N N   . ASN C 1 277 ? 40.134  83.697  1.553   1.00 82.59  ? 277 ASN C N   1 
ATOM   9951  C CA  . ASN C 1 277 ? 40.004  83.791  0.105   1.00 81.00  ? 277 ASN C CA  1 
ATOM   9952  C C   . ASN C 1 277 ? 38.531  83.754  -0.305  1.00 80.94  ? 277 ASN C C   1 
ATOM   9953  O O   . ASN C 1 277 ? 37.919  82.686  -0.291  1.00 76.34  ? 277 ASN C O   1 
ATOM   9954  C CB  . ASN C 1 277 ? 40.760  82.652  -0.575  1.00 77.53  ? 277 ASN C CB  1 
ATOM   9955  C CG  . ASN C 1 277 ? 41.134  82.969  -2.002  1.00 75.70  ? 277 ASN C CG  1 
ATOM   9956  O OD1 . ASN C 1 277 ? 40.407  83.677  -2.707  1.00 74.99  ? 277 ASN C OD1 1 
ATOM   9957  N ND2 . ASN C 1 277 ? 42.285  82.483  -2.437  1.00 77.51  ? 277 ASN C ND2 1 
ATOM   9958  N N   . PRO C 1 278 ? 37.920  84.904  -0.687  1.00 81.45  ? 278 PRO C N   1 
ATOM   9959  C CA  . PRO C 1 278 ? 36.571  84.916  -1.278  1.00 79.41  ? 278 PRO C CA  1 
ATOM   9960  C C   . PRO C 1 278 ? 36.332  84.061  -2.526  1.00 82.34  ? 278 PRO C C   1 
ATOM   9961  O O   . PRO C 1 278 ? 35.195  83.659  -2.772  1.00 79.85  ? 278 PRO C O   1 
ATOM   9962  C CB  . PRO C 1 278 ? 36.346  86.409  -1.592  1.00 78.09  ? 278 PRO C CB  1 
ATOM   9963  C CG  . PRO C 1 278 ? 37.231  87.137  -0.609  1.00 76.56  ? 278 PRO C CG  1 
ATOM   9964  C CD  . PRO C 1 278 ? 38.463  86.256  -0.480  1.00 77.12  ? 278 PRO C CD  1 
ATOM   9965  N N   . ASP C 1 279 ? 37.400  83.798  -3.303  1.00 87.45  ? 279 ASP C N   1 
ATOM   9966  C CA  . ASP C 1 279 ? 37.320  83.046  -4.554  1.00 93.17  ? 279 ASP C CA  1 
ATOM   9967  C C   . ASP C 1 279 ? 37.214  81.538  -4.288  1.00 84.58  ? 279 ASP C C   1 
ATOM   9968  O O   . ASP C 1 279 ? 36.618  80.804  -5.073  1.00 80.96  ? 279 ASP C O   1 
ATOM   9969  C CB  . ASP C 1 279 ? 38.449  83.428  -5.508  1.00 96.81  ? 279 ASP C CB  1 
ATOM   9970  C CG  . ASP C 1 279 ? 38.327  84.813  -6.144  1.00 98.60  ? 279 ASP C CG  1 
ATOM   9971  O OD1 . ASP C 1 279 ? 37.332  85.055  -6.876  1.00 82.95  ? 279 ASP C OD1 1 
ATOM   9972  O OD2 . ASP C 1 279 ? 39.220  85.652  -5.899  1.00 95.10  ? 279 ASP C OD2 1 
ATOM   9973  N N   . HIS C 1 280 ? 37.805  81.072  -3.182  1.00 87.90  ? 280 HIS C N   1 
ATOM   9974  C CA  . HIS C 1 280 ? 37.616  79.710  -2.700  1.00 81.61  ? 280 HIS C CA  1 
ATOM   9975  C C   . HIS C 1 280 ? 36.125  79.421  -2.499  1.00 74.95  ? 280 HIS C C   1 
ATOM   9976  O O   . HIS C 1 280 ? 35.649  78.334  -2.821  1.00 68.63  ? 280 HIS C O   1 
ATOM   9977  C CB  . HIS C 1 280 ? 38.412  79.492  -1.402  1.00 73.88  ? 280 HIS C CB  1 
ATOM   9978  C CG  . HIS C 1 280 ? 38.424  78.070  -0.929  1.00 75.58  ? 280 HIS C CG  1 
ATOM   9979  N ND1 . HIS C 1 280 ? 39.301  77.122  -1.419  1.00 76.97  ? 280 HIS C ND1 1 
ATOM   9980  C CD2 . HIS C 1 280 ? 37.652  77.433  -0.039  1.00 70.99  ? 280 HIS C CD2 1 
ATOM   9981  C CE1 . HIS C 1 280 ? 39.071  75.960  -0.828  1.00 70.24  ? 280 HIS C CE1 1 
ATOM   9982  N NE2 . HIS C 1 280 ? 38.074  76.127  0.014   1.00 68.29  ? 280 HIS C NE2 1 
ATOM   9983  N N   . ALA C 1 281 ? 35.406  80.424  -1.973  1.00 75.65  ? 281 ALA C N   1 
ATOM   9984  C CA  . ALA C 1 281 ? 34.041  80.281  -1.493  1.00 75.96  ? 281 ALA C CA  1 
ATOM   9985  C C   . ALA C 1 281 ? 33.055  80.140  -2.649  1.00 74.61  ? 281 ALA C C   1 
ATOM   9986  O O   . ALA C 1 281 ? 31.950  79.641  -2.454  1.00 86.35  ? 281 ALA C O   1 
ATOM   9987  C CB  . ALA C 1 281 ? 33.689  81.469  -0.611  1.00 66.91  ? 281 ALA C CB  1 
ATOM   9988  N N   . LYS C 1 282 ? 33.439  80.617  -3.839  1.00 81.54  ? 282 LYS C N   1 
ATOM   9989  C CA  . LYS C 1 282 ? 32.543  80.583  -4.984  1.00 83.76  ? 282 LYS C CA  1 
ATOM   9990  C C   . LYS C 1 282 ? 32.647  79.234  -5.701  1.00 83.62  ? 282 LYS C C   1 
ATOM   9991  O O   . LYS C 1 282 ? 31.752  78.900  -6.476  1.00 95.01  ? 282 LYS C O   1 
ATOM   9992  C CB  . LYS C 1 282 ? 32.732  81.789  -5.914  1.00 89.20  ? 282 LYS C CB  1 
ATOM   9993  C CG  . LYS C 1 282 ? 34.139  82.057  -6.417  1.00 101.81 ? 282 LYS C CG  1 
ATOM   9994  C CD  . LYS C 1 282 ? 34.240  83.116  -7.511  1.00 107.50 ? 282 LYS C CD  1 
ATOM   9995  C CE  . LYS C 1 282 ? 33.846  84.479  -7.040  1.00 105.43 ? 282 LYS C CE  1 
ATOM   9996  N NZ  . LYS C 1 282 ? 34.525  85.524  -7.808  1.00 103.85 ? 282 LYS C NZ  1 
ATOM   9997  N N   . TRP C 1 283 ? 33.690  78.439  -5.408  1.00 86.66  ? 283 TRP C N   1 
ATOM   9998  C CA  . TRP C 1 283 ? 33.921  77.182  -6.110  1.00 97.81  ? 283 TRP C CA  1 
ATOM   9999  C C   . TRP C 1 283 ? 33.666  75.958  -5.215  1.00 90.36  ? 283 TRP C C   1 
ATOM   10000 O O   . TRP C 1 283 ? 32.945  75.052  -5.630  1.00 92.60  ? 283 TRP C O   1 
ATOM   10001 C CB  . TRP C 1 283 ? 35.338  77.146  -6.717  1.00 117.41 ? 283 TRP C CB  1 
ATOM   10002 C CG  . TRP C 1 283 ? 35.687  78.284  -7.652  1.00 131.06 ? 283 TRP C CG  1 
ATOM   10003 C CD1 . TRP C 1 283 ? 36.844  79.009  -7.621  1.00 124.83 ? 283 TRP C CD1 1 
ATOM   10004 C CD2 . TRP C 1 283 ? 34.916  78.814  -8.764  1.00 142.55 ? 283 TRP C CD2 1 
ATOM   10005 N NE1 . TRP C 1 283 ? 36.842  79.961  -8.607  1.00 126.20 ? 283 TRP C NE1 1 
ATOM   10006 C CE2 . TRP C 1 283 ? 35.679  79.865  -9.327  1.00 138.01 ? 283 TRP C CE2 1 
ATOM   10007 C CE3 . TRP C 1 283 ? 33.667  78.517  -9.335  1.00 133.29 ? 283 TRP C CE3 1 
ATOM   10008 C CZ2 . TRP C 1 283 ? 35.230  80.607  -10.422 1.00 131.51 ? 283 TRP C CZ2 1 
ATOM   10009 C CZ3 . TRP C 1 283 ? 33.228  79.252  -10.417 1.00 126.37 ? 283 TRP C CZ3 1 
ATOM   10010 C CH2 . TRP C 1 283 ? 34.000  80.282  -10.951 1.00 128.01 ? 283 TRP C CH2 1 
ATOM   10011 N N   . TYR C 1 284 ? 34.251  75.910  -4.005  1.00 78.50  ? 284 TYR C N   1 
ATOM   10012 C CA  . TYR C 1 284 ? 34.401  74.649  -3.273  1.00 78.32  ? 284 TYR C CA  1 
ATOM   10013 C C   . TYR C 1 284 ? 33.208  74.313  -2.363  1.00 76.76  ? 284 TYR C C   1 
ATOM   10014 O O   . TYR C 1 284 ? 32.988  73.138  -2.091  1.00 69.55  ? 284 TYR C O   1 
ATOM   10015 C CB  . TYR C 1 284 ? 35.707  74.581  -2.464  1.00 74.32  ? 284 TYR C CB  1 
ATOM   10016 C CG  . TYR C 1 284 ? 36.942  74.290  -3.309  1.00 79.24  ? 284 TYR C CG  1 
ATOM   10017 C CD1 . TYR C 1 284 ? 37.414  72.987  -3.465  1.00 79.20  ? 284 TYR C CD1 1 
ATOM   10018 C CD2 . TYR C 1 284 ? 37.624  75.310  -3.975  1.00 80.80  ? 284 TYR C CD2 1 
ATOM   10019 C CE1 . TYR C 1 284 ? 38.520  72.708  -4.254  1.00 76.03  ? 284 TYR C CE1 1 
ATOM   10020 C CE2 . TYR C 1 284 ? 38.731  75.043  -4.766  1.00 78.97  ? 284 TYR C CE2 1 
ATOM   10021 C CZ  . TYR C 1 284 ? 39.181  73.739  -4.905  1.00 79.82  ? 284 TYR C CZ  1 
ATOM   10022 O OH  . TYR C 1 284 ? 40.279  73.464  -5.673  1.00 75.33  ? 284 TYR C OH  1 
ATOM   10023 N N   . PRO C 1 285 ? 32.432  75.273  -1.798  1.00 83.95  ? 285 PRO C N   1 
ATOM   10024 C CA  . PRO C 1 285 ? 31.223  74.923  -1.024  1.00 81.46  ? 285 PRO C CA  1 
ATOM   10025 C C   . PRO C 1 285 ? 30.088  74.243  -1.793  1.00 76.05  ? 285 PRO C C   1 
ATOM   10026 O O   . PRO C 1 285 ? 29.334  73.449  -1.225  1.00 65.88  ? 285 PRO C O   1 
ATOM   10027 C CB  . PRO C 1 285 ? 30.755  76.275  -0.477  1.00 74.93  ? 285 PRO C CB  1 
ATOM   10028 C CG  . PRO C 1 285 ? 31.985  77.143  -0.551  1.00 77.72  ? 285 PRO C CG  1 
ATOM   10029 C CD  . PRO C 1 285 ? 32.724  76.715  -1.790  1.00 75.07  ? 285 PRO C CD  1 
ATOM   10030 N N   . GLN C 1 286 ? 29.977  74.610  -3.079  1.00 74.69  ? 286 GLN C N   1 
ATOM   10031 C CA  . GLN C 1 286 ? 29.045  74.031  -4.035  1.00 73.85  ? 286 GLN C CA  1 
ATOM   10032 C C   . GLN C 1 286 ? 29.364  72.547  -4.230  1.00 68.78  ? 286 GLN C C   1 
ATOM   10033 O O   . GLN C 1 286 ? 28.445  71.739  -4.312  1.00 62.15  ? 286 GLN C O   1 
ATOM   10034 C CB  . GLN C 1 286 ? 29.096  74.787  -5.371  1.00 79.68  ? 286 GLN C CB  1 
ATOM   10035 C CG  . GLN C 1 286 ? 28.631  76.245  -5.310  1.00 90.46  ? 286 GLN C CG  1 
ATOM   10036 C CD  . GLN C 1 286 ? 29.623  77.204  -4.671  1.00 99.70  ? 286 GLN C CD  1 
ATOM   10037 O OE1 . GLN C 1 286 ? 30.826  76.925  -4.562  1.00 89.95  ? 286 GLN C OE1 1 
ATOM   10038 N NE2 . GLN C 1 286 ? 29.128  78.356  -4.231  1.00 91.52  ? 286 GLN C NE2 1 
ATOM   10039 N N   . ARG C 1 287 ? 30.661  72.191  -4.276  1.00 69.01  ? 287 ARG C N   1 
ATOM   10040 C CA  . ARG C 1 287 ? 31.098  70.798  -4.322  1.00 74.77  ? 287 ARG C CA  1 
ATOM   10041 C C   . ARG C 1 287 ? 30.667  70.040  -3.056  1.00 69.63  ? 287 ARG C C   1 
ATOM   10042 O O   . ARG C 1 287 ? 30.361  68.845  -3.121  1.00 63.82  ? 287 ARG C O   1 
ATOM   10043 C CB  . ARG C 1 287 ? 32.609  70.696  -4.594  1.00 84.76  ? 287 ARG C CB  1 
ATOM   10044 C CG  . ARG C 1 287 ? 32.989  70.821  -6.067  1.00 99.00  ? 287 ARG C CG  1 
ATOM   10045 C CD  . ARG C 1 287 ? 34.472  70.563  -6.389  1.00 108.73 ? 287 ARG C CD  1 
ATOM   10046 N NE  . ARG C 1 287 ? 35.281  71.789  -6.309  1.00 118.64 ? 287 ARG C NE  1 
ATOM   10047 C CZ  . ARG C 1 287 ? 35.844  72.451  -7.329  1.00 117.86 ? 287 ARG C CZ  1 
ATOM   10048 N NH1 . ARG C 1 287 ? 35.822  71.955  -8.553  1.00 110.63 ? 287 ARG C NH1 1 
ATOM   10049 N NH2 . ARG C 1 287 ? 36.436  73.619  -7.128  1.00 119.68 ? 287 ARG C NH2 1 
ATOM   10050 N N   . GLN C 1 288 ? 30.626  70.737  -1.909  1.00 67.69  ? 288 GLN C N   1 
ATOM   10051 C CA  . GLN C 1 288 ? 30.127  70.167  -0.661  1.00 73.53  ? 288 GLN C CA  1 
ATOM   10052 C C   . GLN C 1 288 ? 28.603  70.026  -0.689  1.00 76.40  ? 288 GLN C C   1 
ATOM   10053 O O   . GLN C 1 288 ? 28.065  69.009  -0.233  1.00 67.93  ? 288 GLN C O   1 
ATOM   10054 C CB  . GLN C 1 288 ? 30.475  70.998  0.577   1.00 65.99  ? 288 GLN C CB  1 
ATOM   10055 C CG  . GLN C 1 288 ? 31.970  71.158  0.826   1.00 68.08  ? 288 GLN C CG  1 
ATOM   10056 C CD  . GLN C 1 288 ? 32.280  72.134  1.941   1.00 73.21  ? 288 GLN C CD  1 
ATOM   10057 O OE1 . GLN C 1 288 ? 32.331  73.361  1.760   1.00 73.81  ? 288 GLN C OE1 1 
ATOM   10058 N NE2 . GLN C 1 288 ? 32.506  71.575  3.120   1.00 72.78  ? 288 GLN C NE2 1 
ATOM   10059 N N   . PHE C 1 289 ? 27.908  71.062  -1.186  1.00 73.12  ? 289 PHE C N   1 
ATOM   10060 C CA  . PHE C 1 289 ? 26.453  71.074  -1.129  1.00 78.86  ? 289 PHE C CA  1 
ATOM   10061 C C   . PHE C 1 289 ? 25.897  70.115  -2.179  1.00 69.97  ? 289 PHE C C   1 
ATOM   10062 O O   . PHE C 1 289 ? 24.747  69.714  -2.065  1.00 73.62  ? 289 PHE C O   1 
ATOM   10063 C CB  . PHE C 1 289 ? 25.885  72.503  -1.152  1.00 87.34  ? 289 PHE C CB  1 
ATOM   10064 C CG  . PHE C 1 289 ? 25.664  73.022  0.263   1.00 96.21  ? 289 PHE C CG  1 
ATOM   10065 C CD1 . PHE C 1 289 ? 24.392  73.031  0.835   1.00 108.77 ? 289 PHE C CD1 1 
ATOM   10066 C CD2 . PHE C 1 289 ? 26.741  73.405  1.057   1.00 102.21 ? 289 PHE C CD2 1 
ATOM   10067 C CE1 . PHE C 1 289 ? 24.200  73.459  2.146   1.00 119.65 ? 289 PHE C CE1 1 
ATOM   10068 C CE2 . PHE C 1 289 ? 26.545  73.832  2.367   1.00 118.34 ? 289 PHE C CE2 1 
ATOM   10069 C CZ  . PHE C 1 289 ? 25.276  73.860  2.910   1.00 119.81 ? 289 PHE C CZ  1 
ATOM   10070 N N   . ASP C 1 290 ? 26.718  69.716  -3.163  1.00 63.82  ? 290 ASP C N   1 
ATOM   10071 C CA  . ASP C 1 290 ? 26.350  68.650  -4.090  1.00 68.56  ? 290 ASP C CA  1 
ATOM   10072 C C   . ASP C 1 290 ? 25.897  67.402  -3.328  1.00 66.93  ? 290 ASP C C   1 
ATOM   10073 O O   . ASP C 1 290 ? 24.987  66.703  -3.766  1.00 56.36  ? 290 ASP C O   1 
ATOM   10074 C CB  . ASP C 1 290 ? 27.498  68.244  -5.008  1.00 67.34  ? 290 ASP C CB  1 
ATOM   10075 C CG  . ASP C 1 290 ? 27.806  69.166  -6.179  1.00 63.35  ? 290 ASP C CG  1 
ATOM   10076 O OD1 . ASP C 1 290 ? 26.945  69.992  -6.513  1.00 58.85  ? 290 ASP C OD1 1 
ATOM   10077 O OD2 . ASP C 1 290 ? 28.922  69.063  -6.735  1.00 70.28  ? 290 ASP C OD2 1 
ATOM   10078 N N   . TRP C 1 291 ? 26.568  67.102  -2.210  1.00 66.29  ? 291 TRP C N   1 
ATOM   10079 C CA  . TRP C 1 291 ? 26.342  65.854  -1.493  1.00 71.23  ? 291 TRP C CA  1 
ATOM   10080 C C   . TRP C 1 291 ? 25.075  65.927  -0.629  1.00 65.85  ? 291 TRP C C   1 
ATOM   10081 O O   . TRP C 1 291 ? 24.388  64.922  -0.412  1.00 55.56  ? 291 TRP C O   1 
ATOM   10082 C CB  . TRP C 1 291 ? 27.608  65.503  -0.696  1.00 69.37  ? 291 TRP C CB  1 
ATOM   10083 C CG  . TRP C 1 291 ? 28.716  65.007  -1.588  1.00 68.60  ? 291 TRP C CG  1 
ATOM   10084 C CD1 . TRP C 1 291 ? 29.743  65.724  -2.133  1.00 70.06  ? 291 TRP C CD1 1 
ATOM   10085 C CD2 . TRP C 1 291 ? 28.859  63.655  -2.083  1.00 67.70  ? 291 TRP C CD2 1 
ATOM   10086 N NE1 . TRP C 1 291 ? 30.524  64.913  -2.914  1.00 69.82  ? 291 TRP C NE1 1 
ATOM   10087 C CE2 . TRP C 1 291 ? 30.006  63.641  -2.910  1.00 72.48  ? 291 TRP C CE2 1 
ATOM   10088 C CE3 . TRP C 1 291 ? 28.134  62.468  -1.907  1.00 68.78  ? 291 TRP C CE3 1 
ATOM   10089 C CZ2 . TRP C 1 291 ? 30.439  62.479  -3.554  1.00 74.08  ? 291 TRP C CZ2 1 
ATOM   10090 C CZ3 . TRP C 1 291 ? 28.559  61.323  -2.548  1.00 70.79  ? 291 TRP C CZ3 1 
ATOM   10091 C CH2 . TRP C 1 291 ? 29.694  61.334  -3.364  1.00 72.73  ? 291 TRP C CH2 1 
ATOM   10092 N N   . VAL C 1 292 ? 24.767  67.138  -0.159  1.00 57.39  ? 292 VAL C N   1 
ATOM   10093 C CA  . VAL C 1 292 ? 23.502  67.438  0.491   1.00 63.26  ? 292 VAL C CA  1 
ATOM   10094 C C   . VAL C 1 292 ? 22.356  67.253  -0.507  1.00 65.40  ? 292 VAL C C   1 
ATOM   10095 O O   . VAL C 1 292 ? 21.324  66.675  -0.171  1.00 61.69  ? 292 VAL C O   1 
ATOM   10096 C CB  . VAL C 1 292 ? 23.559  68.891  1.009   1.00 62.31  ? 292 VAL C CB  1 
ATOM   10097 C CG1 . VAL C 1 292 ? 22.186  69.412  1.432   1.00 58.79  ? 292 VAL C CG1 1 
ATOM   10098 C CG2 . VAL C 1 292 ? 24.606  69.059  2.108   1.00 67.74  ? 292 VAL C CG2 1 
ATOM   10099 N N   . HIS C 1 293 ? 22.552  67.798  -1.716  1.00 60.88  ? 293 HIS C N   1 
ATOM   10100 C CA  . HIS C 1 293 ? 21.570  67.776  -2.787  1.00 60.24  ? 293 HIS C CA  1 
ATOM   10101 C C   . HIS C 1 293 ? 21.208  66.332  -3.132  1.00 61.62  ? 293 HIS C C   1 
ATOM   10102 O O   . HIS C 1 293 ? 20.024  66.008  -3.232  1.00 60.50  ? 293 HIS C O   1 
ATOM   10103 C CB  . HIS C 1 293 ? 22.080  68.606  -3.979  1.00 55.35  ? 293 HIS C CB  1 
ATOM   10104 C CG  . HIS C 1 293 ? 22.081  70.088  -3.724  1.00 57.83  ? 293 HIS C CG  1 
ATOM   10105 N ND1 . HIS C 1 293 ? 22.877  70.982  -4.408  1.00 59.59  ? 293 HIS C ND1 1 
ATOM   10106 C CD2 . HIS C 1 293 ? 21.365  70.824  -2.855  1.00 55.80  ? 293 HIS C CD2 1 
ATOM   10107 C CE1 . HIS C 1 293 ? 22.659  72.207  -3.951  1.00 64.72  ? 293 HIS C CE1 1 
ATOM   10108 N NE2 . HIS C 1 293 ? 21.740  72.133  -3.011  1.00 66.29  ? 293 HIS C NE2 1 
ATOM   10109 N N   . ILE C 1 294 ? 22.237  65.479  -3.277  1.00 62.84  ? 294 ILE C N   1 
ATOM   10110 C CA  . ILE C 1 294 ? 22.088  64.057  -3.565  1.00 59.54  ? 294 ILE C CA  1 
ATOM   10111 C C   . ILE C 1 294 ? 21.160  63.411  -2.530  1.00 60.95  ? 294 ILE C C   1 
ATOM   10112 O O   . ILE C 1 294 ? 20.211  62.710  -2.888  1.00 56.52  ? 294 ILE C O   1 
ATOM   10113 C CB  . ILE C 1 294 ? 23.472  63.374  -3.611  1.00 61.32  ? 294 ILE C CB  1 
ATOM   10114 C CG1 . ILE C 1 294 ? 24.296  63.852  -4.815  1.00 63.69  ? 294 ILE C CG1 1 
ATOM   10115 C CG2 . ILE C 1 294 ? 23.344  61.848  -3.613  1.00 72.88  ? 294 ILE C CG2 1 
ATOM   10116 C CD1 . ILE C 1 294 ? 25.769  63.477  -4.775  1.00 63.30  ? 294 ILE C CD1 1 
ATOM   10117 N N   . GLU C 1 295 ? 21.453  63.649  -1.246  1.00 57.14  ? 295 GLU C N   1 
ATOM   10118 C CA  . GLU C 1 295 ? 20.694  63.088  -0.134  1.00 58.95  ? 295 GLU C CA  1 
ATOM   10119 C C   . GLU C 1 295 ? 19.251  63.622  -0.143  1.00 55.73  ? 295 GLU C C   1 
ATOM   10120 O O   . GLU C 1 295 ? 18.274  62.863  -0.021  1.00 50.43  ? 295 GLU C O   1 
ATOM   10121 C CB  . GLU C 1 295 ? 21.547  63.410  1.098   1.00 61.00  ? 295 GLU C CB  1 
ATOM   10122 C CG  . GLU C 1 295 ? 20.938  62.972  2.423   1.00 71.41  ? 295 GLU C CG  1 
ATOM   10123 C CD  . GLU C 1 295 ? 19.956  63.943  3.050   1.00 72.23  ? 295 GLU C CD  1 
ATOM   10124 O OE1 . GLU C 1 295 ? 19.906  65.111  2.596   1.00 60.99  ? 295 GLU C OE1 1 
ATOM   10125 O OE2 . GLU C 1 295 ? 19.249  63.511  3.998   1.00 79.84  ? 295 GLU C OE2 1 
ATOM   10126 N N   . THR C 1 296 ? 19.120  64.943  -0.311  1.00 48.60  ? 296 THR C N   1 
ATOM   10127 C CA  . THR C 1 296 ? 17.817  65.587  -0.357  1.00 54.52  ? 296 THR C CA  1 
ATOM   10128 C C   . THR C 1 296 ? 16.971  64.934  -1.444  1.00 45.07  ? 296 THR C C   1 
ATOM   10129 O O   . THR C 1 296 ? 15.825  64.605  -1.196  1.00 50.43  ? 296 THR C O   1 
ATOM   10130 C CB  . THR C 1 296 ? 17.954  67.097  -0.593  1.00 57.90  ? 296 THR C CB  1 
ATOM   10131 O OG1 . THR C 1 296 ? 18.461  67.615  0.635   1.00 61.62  ? 296 THR C OG1 1 
ATOM   10132 C CG2 . THR C 1 296 ? 16.631  67.753  -0.964  1.00 54.26  ? 296 THR C CG2 1 
ATOM   10133 N N   . GLN C 1 297 ? 17.556  64.768  -2.634  1.00 45.32  ? 297 GLN C N   1 
ATOM   10134 C CA  . GLN C 1 297 ? 16.856  64.290  -3.824  1.00 54.35  ? 297 GLN C CA  1 
ATOM   10135 C C   . GLN C 1 297 ? 16.330  62.865  -3.628  1.00 51.43  ? 297 GLN C C   1 
ATOM   10136 O O   . GLN C 1 297 ? 15.265  62.510  -4.139  1.00 47.23  ? 297 GLN C O   1 
ATOM   10137 C CB  . GLN C 1 297 ? 17.799  64.364  -5.029  1.00 58.73  ? 297 GLN C CB  1 
ATOM   10138 C CG  . GLN C 1 297 ? 17.095  64.483  -6.377  1.00 63.83  ? 297 GLN C CG  1 
ATOM   10139 C CD  . GLN C 1 297 ? 16.826  63.145  -7.021  1.00 60.14  ? 297 GLN C CD  1 
ATOM   10140 O OE1 . GLN C 1 297 ? 17.729  62.305  -7.099  1.00 58.68  ? 297 GLN C OE1 1 
ATOM   10141 N NE2 . GLN C 1 297 ? 15.593  62.948  -7.480  1.00 54.58  ? 297 GLN C NE2 1 
ATOM   10142 N N   . ILE C 1 298 ? 17.067  62.051  -2.867  1.00 54.96  ? 298 ILE C N   1 
ATOM   10143 C CA  . ILE C 1 298 ? 16.587  60.718  -2.522  1.00 61.21  ? 298 ILE C CA  1 
ATOM   10144 C C   . ILE C 1 298 ? 15.388  60.849  -1.574  1.00 55.39  ? 298 ILE C C   1 
ATOM   10145 O O   . ILE C 1 298 ? 14.366  60.202  -1.788  1.00 56.51  ? 298 ILE C O   1 
ATOM   10146 C CB  . ILE C 1 298 ? 17.728  59.841  -1.967  1.00 66.50  ? 298 ILE C CB  1 
ATOM   10147 C CG1 . ILE C 1 298 ? 18.861  59.658  -3.013  1.00 66.44  ? 298 ILE C CG1 1 
ATOM   10148 C CG2 . ILE C 1 298 ? 17.188  58.495  -1.486  1.00 70.10  ? 298 ILE C CG2 1 
ATOM   10149 C CD1 . ILE C 1 298 ? 20.192  59.209  -2.428  1.00 66.32  ? 298 ILE C CD1 1 
ATOM   10150 N N   . ARG C 1 299 ? 15.478  61.752  -0.587  1.00 54.10  ? 299 ARG C N   1 
ATOM   10151 C CA  . ARG C 1 299 ? 14.373  62.022  0.322   1.00 54.19  ? 299 ARG C CA  1 
ATOM   10152 C C   . ARG C 1 299 ? 13.103  62.436  -0.434  1.00 54.40  ? 299 ARG C C   1 
ATOM   10153 O O   . ARG C 1 299 ? 12.006  61.952  -0.121  1.00 49.61  ? 299 ARG C O   1 
ATOM   10154 C CB  . ARG C 1 299 ? 14.798  63.067  1.354   1.00 53.20  ? 299 ARG C CB  1 
ATOM   10155 C CG  . ARG C 1 299 ? 13.754  63.266  2.441   1.00 60.02  ? 299 ARG C CG  1 
ATOM   10156 C CD  . ARG C 1 299 ? 14.263  64.159  3.566   1.00 65.79  ? 299 ARG C CD  1 
ATOM   10157 N NE  . ARG C 1 299 ? 14.626  65.503  3.091   1.00 67.10  ? 299 ARG C NE  1 
ATOM   10158 C CZ  . ARG C 1 299 ? 15.873  65.973  3.010   1.00 69.83  ? 299 ARG C CZ  1 
ATOM   10159 N NH1 . ARG C 1 299 ? 16.903  65.198  3.321   1.00 67.70  ? 299 ARG C NH1 1 
ATOM   10160 N NH2 . ARG C 1 299 ? 16.093  67.215  2.609   1.00 76.64  ? 299 ARG C NH2 1 
ATOM   10161 N N   . HIS C 1 300 ? 13.261  63.297  -1.452  1.00 50.78  ? 300 HIS C N   1 
ATOM   10162 C CA  . HIS C 1 300 ? 12.144  63.747  -2.270  1.00 51.41  ? 300 HIS C CA  1 
ATOM   10163 C C   . HIS C 1 300 ? 11.317  62.553  -2.742  1.00 48.96  ? 300 HIS C C   1 
ATOM   10164 O O   . HIS C 1 300 ? 10.079  62.545  -2.644  1.00 45.58  ? 300 HIS C O   1 
ATOM   10165 C CB  . HIS C 1 300 ? 12.638  64.579  -3.465  1.00 50.85  ? 300 HIS C CB  1 
ATOM   10166 C CG  . HIS C 1 300 ? 13.133  65.935  -3.089  1.00 51.21  ? 300 HIS C CG  1 
ATOM   10167 N ND1 . HIS C 1 300 ? 13.797  66.758  -3.969  1.00 53.01  ? 300 HIS C ND1 1 
ATOM   10168 C CD2 . HIS C 1 300 ? 13.018  66.624  -1.945  1.00 49.77  ? 300 HIS C CD2 1 
ATOM   10169 C CE1 . HIS C 1 300 ? 14.101  67.888  -3.355  1.00 48.91  ? 300 HIS C CE1 1 
ATOM   10170 N NE2 . HIS C 1 300 ? 13.638  67.826  -2.126  1.00 49.93  ? 300 HIS C NE2 1 
ATOM   10171 N N   . ALA C 1 301 ? 12.031  61.554  -3.267  1.00 45.77  ? 301 ALA C N   1 
ATOM   10172 C CA  . ALA C 1 301 ? 11.397  60.424  -3.918  1.00 49.51  ? 301 ALA C CA  1 
ATOM   10173 C C   . ALA C 1 301 ? 10.636  59.618  -2.875  1.00 47.18  ? 301 ALA C C   1 
ATOM   10174 O O   . ALA C 1 301 ? 9.507   59.185  -3.113  1.00 55.18  ? 301 ALA C O   1 
ATOM   10175 C CB  . ALA C 1 301 ? 12.434  59.597  -4.663  1.00 52.31  ? 301 ALA C CB  1 
ATOM   10176 N N   . VAL C 1 302 ? 11.235  59.470  -1.695  1.00 47.46  ? 302 VAL C N   1 
ATOM   10177 C CA  . VAL C 1 302 ? 10.590  58.722  -0.626  1.00 52.78  ? 302 VAL C CA  1 
ATOM   10178 C C   . VAL C 1 302 ? 9.339   59.469  -0.162  1.00 49.14  ? 302 VAL C C   1 
ATOM   10179 O O   . VAL C 1 302 ? 8.317   58.847  0.143   1.00 46.51  ? 302 VAL C O   1 
ATOM   10180 C CB  . VAL C 1 302 ? 11.549  58.454  0.548   1.00 54.21  ? 302 VAL C CB  1 
ATOM   10181 C CG1 . VAL C 1 302 ? 10.861  57.686  1.669   1.00 51.67  ? 302 VAL C CG1 1 
ATOM   10182 C CG2 . VAL C 1 302 ? 12.808  57.722  0.089   1.00 53.52  ? 302 VAL C CG2 1 
ATOM   10183 N N   . HIS C 1 303 ? 9.434   60.804  -0.101  1.00 45.97  ? 303 HIS C N   1 
ATOM   10184 C CA  . HIS C 1 303 ? 8.317   61.627  0.332   1.00 50.87  ? 303 HIS C CA  1 
ATOM   10185 C C   . HIS C 1 303 ? 7.163   61.472  -0.673  1.00 50.39  ? 303 HIS C C   1 
ATOM   10186 O O   . HIS C 1 303 ? 6.008   61.236  -0.284  1.00 41.92  ? 303 HIS C O   1 
ATOM   10187 C CB  . HIS C 1 303 ? 8.789   63.071  0.588   1.00 49.81  ? 303 HIS C CB  1 
ATOM   10188 C CG  . HIS C 1 303 ? 7.725   63.947  1.188   1.00 58.09  ? 303 HIS C CG  1 
ATOM   10189 N ND1 . HIS C 1 303 ? 7.574   65.300  0.936   1.00 56.92  ? 303 HIS C ND1 1 
ATOM   10190 C CD2 . HIS C 1 303 ? 6.733   63.611  2.037   1.00 55.02  ? 303 HIS C CD2 1 
ATOM   10191 C CE1 . HIS C 1 303 ? 6.535   65.754  1.621   1.00 55.65  ? 303 HIS C CE1 1 
ATOM   10192 N NE2 . HIS C 1 303 ? 6.004   64.740  2.289   1.00 55.71  ? 303 HIS C NE2 1 
ATOM   10193 N N   . ALA C 1 304 ? 7.477   61.580  -1.976  1.00 45.68  ? 304 ALA C N   1 
ATOM   10194 C CA  . ALA C 1 304 ? 6.482   61.382  -3.032  1.00 47.60  ? 304 ALA C CA  1 
ATOM   10195 C C   . ALA C 1 304 ? 5.884   59.972  -2.948  1.00 41.85  ? 304 ALA C C   1 
ATOM   10196 O O   . ALA C 1 304 ? 4.678   59.773  -3.138  1.00 40.58  ? 304 ALA C O   1 
ATOM   10197 C CB  . ALA C 1 304 ? 7.094   61.658  -4.414  1.00 47.89  ? 304 ALA C CB  1 
ATOM   10198 N N   . GLU C 1 305 ? 6.707   58.987  -2.576  1.00 45.87  ? 305 GLU C N   1 
ATOM   10199 C CA  . GLU C 1 305 ? 6.185   57.643  -2.355  1.00 47.07  ? 305 GLU C CA  1 
ATOM   10200 C C   . GLU C 1 305 ? 5.183   57.660  -1.200  1.00 48.08  ? 305 GLU C C   1 
ATOM   10201 O O   . GLU C 1 305 ? 4.107   57.067  -1.303  1.00 48.21  ? 305 GLU C O   1 
ATOM   10202 C CB  . GLU C 1 305 ? 7.341   56.660  -2.185  1.00 50.06  ? 305 GLU C CB  1 
ATOM   10203 C CG  . GLU C 1 305 ? 6.915   55.323  -1.589  1.00 51.24  ? 305 GLU C CG  1 
ATOM   10204 C CD  . GLU C 1 305 ? 8.042   54.318  -1.493  1.00 53.23  ? 305 GLU C CD  1 
ATOM   10205 O OE1 . GLU C 1 305 ? 9.165   54.608  -1.961  1.00 56.84  ? 305 GLU C OE1 1 
ATOM   10206 O OE2 . GLU C 1 305 ? 7.782   53.244  -0.915  1.00 57.17  ? 305 GLU C OE2 1 
ATOM   10207 N N   . LEU C 1 306 ? 5.527   58.352  -0.102  1.00 47.89  ? 306 LEU C N   1 
ATOM   10208 C CA  . LEU C 1 306 ? 4.627   58.441  1.038   1.00 47.99  ? 306 LEU C CA  1 
ATOM   10209 C C   . LEU C 1 306 ? 3.307   59.095  0.625   1.00 47.39  ? 306 LEU C C   1 
ATOM   10210 O O   . LEU C 1 306 ? 2.232   58.662  1.034   1.00 44.86  ? 306 LEU C O   1 
ATOM   10211 C CB  . LEU C 1 306 ? 5.283   59.207  2.181   1.00 50.88  ? 306 LEU C CB  1 
ATOM   10212 C CG  . LEU C 1 306 ? 4.361   59.490  3.370   1.00 56.61  ? 306 LEU C CG  1 
ATOM   10213 C CD1 . LEU C 1 306 ? 4.067   58.214  4.141   1.00 57.94  ? 306 LEU C CD1 1 
ATOM   10214 C CD2 . LEU C 1 306 ? 4.934   60.559  4.265   1.00 60.75  ? 306 LEU C CD2 1 
ATOM   10215 N N   . ILE C 1 307 ? 3.402   60.129  -0.210  1.00 47.45  ? 307 ILE C N   1 
ATOM   10216 C CA  . ILE C 1 307 ? 2.239   60.896  -0.610  1.00 45.85  ? 307 ILE C CA  1 
ATOM   10217 C C   . ILE C 1 307 ? 1.290   60.024  -1.426  1.00 45.31  ? 307 ILE C C   1 
ATOM   10218 O O   . ILE C 1 307 ? 0.129   59.873  -1.049  1.00 47.65  ? 307 ILE C O   1 
ATOM   10219 C CB  . ILE C 1 307 ? 2.677   62.189  -1.323  1.00 45.01  ? 307 ILE C CB  1 
ATOM   10220 C CG1 . ILE C 1 307 ? 3.223   63.196  -0.265  1.00 48.68  ? 307 ILE C CG1 1 
ATOM   10221 C CG2 . ILE C 1 307 ? 1.531   62.766  -2.154  1.00 45.28  ? 307 ILE C CG2 1 
ATOM   10222 C CD1 . ILE C 1 307 ? 3.833   64.483  -0.808  1.00 50.16  ? 307 ILE C CD1 1 
ATOM   10223 N N   . VAL C 1 308 ? 1.777   59.413  -2.511  1.00 51.56  ? 308 VAL C N   1 
ATOM   10224 C CA  . VAL C 1 308 ? 0.922   58.519  -3.292  1.00 54.40  ? 308 VAL C CA  1 
ATOM   10225 C C   . VAL C 1 308 ? 0.325   57.425  -2.391  1.00 45.47  ? 308 VAL C C   1 
ATOM   10226 O O   . VAL C 1 308 ? -0.868  57.131  -2.480  1.00 43.41  ? 308 VAL C O   1 
ATOM   10227 C CB  . VAL C 1 308 ? 1.562   57.897  -4.555  1.00 57.89  ? 308 VAL C CB  1 
ATOM   10228 C CG1 . VAL C 1 308 ? 3.013   57.494  -4.371  1.00 57.91  ? 308 VAL C CG1 1 
ATOM   10229 C CG2 . VAL C 1 308 ? 0.758   56.704  -5.069  1.00 65.34  ? 308 VAL C CG2 1 
ATOM   10230 N N   . GLY C 1 309 ? 1.136   56.816  -1.524  1.00 44.14  ? 309 GLY C N   1 
ATOM   10231 C CA  . GLY C 1 309 ? 0.631   55.794  -0.616  1.00 49.67  ? 309 GLY C CA  1 
ATOM   10232 C C   . GLY C 1 309 ? -0.564  56.301  0.192   1.00 50.61  ? 309 GLY C C   1 
ATOM   10233 O O   . GLY C 1 309 ? -1.617  55.651  0.218   1.00 47.92  ? 309 GLY C O   1 
ATOM   10234 N N   . LEU C 1 310 ? -0.407  57.483  0.818   1.00 46.80  ? 310 LEU C N   1 
ATOM   10235 C CA  . LEU C 1 310 ? -1.480  58.071  1.612   1.00 47.46  ? 310 LEU C CA  1 
ATOM   10236 C C   . LEU C 1 310 ? -2.698  58.313  0.719   1.00 52.60  ? 310 LEU C C   1 
ATOM   10237 O O   . LEU C 1 310 ? -3.837  58.101  1.135   1.00 51.51  ? 310 LEU C O   1 
ATOM   10238 C CB  . LEU C 1 310 ? -1.027  59.352  2.312   1.00 46.52  ? 310 LEU C CB  1 
ATOM   10239 C CG  . LEU C 1 310 ? -0.031  59.190  3.465   1.00 46.74  ? 310 LEU C CG  1 
ATOM   10240 C CD1 . LEU C 1 310 ? 0.622   60.498  3.873   1.00 46.19  ? 310 LEU C CD1 1 
ATOM   10241 C CD2 . LEU C 1 310 ? -0.715  58.573  4.675   1.00 50.47  ? 310 LEU C CD2 1 
ATOM   10242 N N   . ALA C 1 311 ? -2.447  58.732  -0.526  1.00 49.75  ? 311 ALA C N   1 
ATOM   10243 C CA  . ALA C 1 311 ? -3.516  59.010  -1.468  1.00 51.88  ? 311 ALA C CA  1 
ATOM   10244 C C   . ALA C 1 311 ? -4.275  57.728  -1.819  1.00 48.09  ? 311 ALA C C   1 
ATOM   10245 O O   . ALA C 1 311 ? -5.504  57.715  -1.835  1.00 45.60  ? 311 ALA C O   1 
ATOM   10246 C CB  . ALA C 1 311 ? -2.941  59.691  -2.698  1.00 54.06  ? 311 ALA C CB  1 
ATOM   10247 N N   . LEU C 1 312 ? -3.543  56.651  -2.112  1.00 51.79  ? 312 LEU C N   1 
ATOM   10248 C CA  . LEU C 1 312 ? -4.168  55.352  -2.376  1.00 54.75  ? 312 LEU C CA  1 
ATOM   10249 C C   . LEU C 1 312 ? -5.035  54.889  -1.200  1.00 46.92  ? 312 LEU C C   1 
ATOM   10250 O O   . LEU C 1 312 ? -6.186  54.516  -1.402  1.00 50.09  ? 312 LEU C O   1 
ATOM   10251 C CB  . LEU C 1 312 ? -3.103  54.315  -2.735  1.00 52.18  ? 312 LEU C CB  1 
ATOM   10252 C CG  . LEU C 1 312 ? -2.595  54.378  -4.178  1.00 57.01  ? 312 LEU C CG  1 
ATOM   10253 C CD1 . LEU C 1 312 ? -1.364  53.495  -4.433  1.00 59.60  ? 312 LEU C CD1 1 
ATOM   10254 C CD2 . LEU C 1 312 ? -3.744  53.999  -5.105  1.00 56.78  ? 312 LEU C CD2 1 
ATOM   10255 N N   . LEU C 1 313 ? -4.508  54.955  0.032   1.00 46.54  ? 313 LEU C N   1 
ATOM   10256 C CA  . LEU C 1 313 ? -5.258  54.518  1.206   1.00 48.45  ? 313 LEU C CA  1 
ATOM   10257 C C   . LEU C 1 313 ? -6.501  55.386  1.383   1.00 54.65  ? 313 LEU C C   1 
ATOM   10258 O O   . LEU C 1 313 ? -7.602  54.856  1.543   1.00 51.01  ? 313 LEU C O   1 
ATOM   10259 C CB  . LEU C 1 313 ? -4.368  54.545  2.448   1.00 46.87  ? 313 LEU C CB  1 
ATOM   10260 C CG  . LEU C 1 313 ? -3.282  53.467  2.483   1.00 55.71  ? 313 LEU C CG  1 
ATOM   10261 C CD1 . LEU C 1 313 ? -2.099  53.883  3.324   1.00 57.61  ? 313 LEU C CD1 1 
ATOM   10262 C CD2 . LEU C 1 313 ? -3.853  52.142  2.988   1.00 55.95  ? 313 LEU C CD2 1 
ATOM   10263 N N   . LEU C 1 314 ? -6.293  56.717  1.324   1.00 56.67  ? 314 LEU C N   1 
ATOM   10264 C CA  . LEU C 1 314 ? -7.326  57.714  1.548   1.00 50.55  ? 314 LEU C CA  1 
ATOM   10265 C C   . LEU C 1 314 ? -8.471  57.556  0.546   1.00 54.25  ? 314 LEU C C   1 
ATOM   10266 O O   . LEU C 1 314 ? -9.644  57.507  0.940   1.00 52.43  ? 314 LEU C O   1 
ATOM   10267 C CB  . LEU C 1 314 ? -6.709  59.107  1.455   1.00 53.73  ? 314 LEU C CB  1 
ATOM   10268 C CG  . LEU C 1 314 ? -7.693  60.280  1.533   1.00 58.31  ? 314 LEU C CG  1 
ATOM   10269 C CD1 . LEU C 1 314 ? -8.361  60.365  2.907   1.00 52.80  ? 314 LEU C CD1 1 
ATOM   10270 C CD2 . LEU C 1 314 ? -7.005  61.588  1.139   1.00 60.10  ? 314 LEU C CD2 1 
ATOM   10271 N N   . THR C 1 315 ? -8.146  57.524  -0.754  1.00 48.58  ? 315 THR C N   1 
ATOM   10272 C CA  . THR C 1 315 ? -9.202  57.482  -1.751  1.00 54.29  ? 315 THR C CA  1 
ATOM   10273 C C   . THR C 1 315 ? -9.908  56.135  -1.651  1.00 55.65  ? 315 THR C C   1 
ATOM   10274 O O   . THR C 1 315 ? -11.113 56.068  -1.876  1.00 53.47  ? 315 THR C O   1 
ATOM   10275 C CB  . THR C 1 315 ? -8.686  57.773  -3.162  1.00 54.15  ? 315 THR C CB  1 
ATOM   10276 O OG1 . THR C 1 315 ? -7.639  56.844  -3.425  1.00 47.78  ? 315 THR C OG1 1 
ATOM   10277 C CG2 . THR C 1 315 ? -8.199  59.212  -3.296  1.00 56.32  ? 315 THR C CG2 1 
ATOM   10278 N N   . ASN C 1 316 ? -9.159  55.090  -1.261  1.00 58.24  ? 316 ASN C N   1 
ATOM   10279 C CA  . ASN C 1 316 ? -9.732  53.766  -1.089  1.00 58.11  ? 316 ASN C CA  1 
ATOM   10280 C C   . ASN C 1 316 ? -10.693 53.779  0.101   1.00 53.47  ? 316 ASN C C   1 
ATOM   10281 O O   . ASN C 1 316 ? -11.814 53.293  -0.008  1.00 55.51  ? 316 ASN C O   1 
ATOM   10282 C CB  . ASN C 1 316 ? -8.661  52.683  -0.987  1.00 59.40  ? 316 ASN C CB  1 
ATOM   10283 C CG  . ASN C 1 316 ? -9.267  51.299  -1.055  1.00 62.66  ? 316 ASN C CG  1 
ATOM   10284 O OD1 . ASN C 1 316 ? -9.566  50.804  -2.149  1.00 57.73  ? 316 ASN C OD1 1 
ATOM   10285 N ND2 . ASN C 1 316 ? -9.480  50.674  0.095   1.00 65.02  ? 316 ASN C ND2 1 
ATOM   10286 N N   . ALA C 1 317 ? -10.272 54.371  1.225   1.00 50.77  ? 317 ALA C N   1 
ATOM   10287 C CA  . ALA C 1 317 ? -11.102 54.413  2.418   1.00 52.19  ? 317 ALA C CA  1 
ATOM   10288 C C   . ALA C 1 317 ? -12.351 55.276  2.219   1.00 53.77  ? 317 ALA C C   1 
ATOM   10289 O O   . ALA C 1 317 ? -13.340 55.102  2.919   1.00 54.96  ? 317 ALA C O   1 
ATOM   10290 C CB  . ALA C 1 317 ? -10.272 54.920  3.572   1.00 54.09  ? 317 ALA C CB  1 
ATOM   10291 N N   . LEU C 1 318 ? -12.289 56.249  1.303   1.00 58.77  ? 318 LEU C N   1 
ATOM   10292 C CA  . LEU C 1 318 ? -13.404 57.148  1.060   1.00 59.52  ? 318 LEU C CA  1 
ATOM   10293 C C   . LEU C 1 318 ? -14.324 56.586  -0.019  1.00 59.46  ? 318 LEU C C   1 
ATOM   10294 O O   . LEU C 1 318 ? -15.448 57.050  -0.122  1.00 61.34  ? 318 LEU C O   1 
ATOM   10295 C CB  . LEU C 1 318 ? -12.924 58.556  0.692   1.00 57.27  ? 318 LEU C CB  1 
ATOM   10296 C CG  . LEU C 1 318 ? -12.416 59.423  1.850   1.00 55.31  ? 318 LEU C CG  1 
ATOM   10297 C CD1 . LEU C 1 318 ? -11.763 60.723  1.341   1.00 55.52  ? 318 LEU C CD1 1 
ATOM   10298 C CD2 . LEU C 1 318 ? -13.546 59.725  2.818   1.00 51.12  ? 318 LEU C CD2 1 
ATOM   10299 N N   . GLY C 1 319 ? -13.832 55.661  -0.853  1.00 61.91  ? 319 GLY C N   1 
ATOM   10300 C CA  . GLY C 1 319 ? -14.623 55.055  -1.919  1.00 64.59  ? 319 GLY C CA  1 
ATOM   10301 C C   . GLY C 1 319 ? -14.531 55.807  -3.257  1.00 67.82  ? 319 GLY C C   1 
ATOM   10302 O O   . GLY C 1 319 ? -15.330 55.555  -4.157  1.00 60.18  ? 319 GLY C O   1 
ATOM   10303 N N   . THR C 1 320 ? -13.531 56.690  -3.413  1.00 62.41  ? 320 THR C N   1 
ATOM   10304 C CA  . THR C 1 320 ? -13.466 57.585  -4.561  1.00 64.93  ? 320 THR C CA  1 
ATOM   10305 C C   . THR C 1 320 ? -12.410 57.126  -5.566  1.00 61.57  ? 320 THR C C   1 
ATOM   10306 O O   . THR C 1 320 ? -12.176 57.821  -6.555  1.00 62.65  ? 320 THR C O   1 
ATOM   10307 C CB  . THR C 1 320 ? -13.190 59.032  -4.125  1.00 65.21  ? 320 THR C CB  1 
ATOM   10308 O OG1 . THR C 1 320 ? -11.991 59.046  -3.352  1.00 62.36  ? 320 THR C OG1 1 
ATOM   10309 C CG2 . THR C 1 320 ? -14.341 59.645  -3.345  1.00 61.91  ? 320 THR C CG2 1 
ATOM   10310 N N   . ASN C 1 321 ? -11.799 55.956  -5.350  1.00 58.29  ? 321 ASN C N   1 
ATOM   10311 C CA  . ASN C 1 321 ? -10.619 55.577  -6.123  1.00 63.96  ? 321 ASN C CA  1 
ATOM   10312 C C   . ASN C 1 321 ? -11.014 54.998  -7.491  1.00 66.06  ? 321 ASN C C   1 
ATOM   10313 O O   . ASN C 1 321 ? -10.157 54.864  -8.364  1.00 60.87  ? 321 ASN C O   1 
ATOM   10314 C CB  . ASN C 1 321 ? -9.677  54.697  -5.298  1.00 66.45  ? 321 ASN C CB  1 
ATOM   10315 C CG  . ASN C 1 321 ? -10.289 53.384  -4.861  1.00 68.92  ? 321 ASN C CG  1 
ATOM   10316 O OD1 . ASN C 1 321 ? -11.428 53.337  -4.373  1.00 67.66  ? 321 ASN C OD1 1 
ATOM   10317 N ND2 . ASN C 1 321 ? -9.545  52.305  -5.031  1.00 74.20  ? 321 ASN C ND2 1 
ATOM   10318 N N   . ASN C 1 322 ? -12.312 54.705  -7.684  1.00 69.94  ? 322 ASN C N   1 
ATOM   10319 C CA  . ASN C 1 322 ? -12.849 54.196  -8.941  1.00 81.96  ? 322 ASN C CA  1 
ATOM   10320 C C   . ASN C 1 322 ? -13.349 55.323  -9.859  1.00 70.40  ? 322 ASN C C   1 
ATOM   10321 O O   . ASN C 1 322 ? -13.621 55.060  -11.026 1.00 69.06  ? 322 ASN C O   1 
ATOM   10322 C CB  . ASN C 1 322 ? -13.987 53.215  -8.681  1.00 95.15  ? 322 ASN C CB  1 
ATOM   10323 C CG  . ASN C 1 322 ? -15.071 53.870  -7.855  1.00 116.37 ? 322 ASN C CG  1 
ATOM   10324 O OD1 . ASN C 1 322 ? -14.836 54.219  -6.690  1.00 113.11 ? 322 ASN C OD1 1 
ATOM   10325 N ND2 . ASN C 1 322 ? -16.236 54.096  -8.447  1.00 122.22 ? 322 ASN C ND2 1 
ATOM   10326 N N   . ASN C 1 323 ? -13.511 56.552  -9.331  1.00 71.44  ? 323 ASN C N   1 
ATOM   10327 C CA  . ASN C 1 323 ? -13.814 57.746  -10.120 1.00 65.21  ? 323 ASN C CA  1 
ATOM   10328 C C   . ASN C 1 323 ? -12.696 57.935  -11.148 1.00 59.64  ? 323 ASN C C   1 
ATOM   10329 O O   . ASN C 1 323 ? -11.516 57.899  -10.800 1.00 50.44  ? 323 ASN C O   1 
ATOM   10330 C CB  . ASN C 1 323 ? -13.985 58.980  -9.224  1.00 72.80  ? 323 ASN C CB  1 
ATOM   10331 C CG  . ASN C 1 323 ? -14.377 60.268  -9.936  1.00 81.67  ? 323 ASN C CG  1 
ATOM   10332 O OD1 . ASN C 1 323 ? -14.026 60.514  -11.099 1.00 81.44  ? 323 ASN C OD1 1 
ATOM   10333 N ND2 . ASN C 1 323 ? -15.104 61.136  -9.245  1.00 79.49  ? 323 ASN C ND2 1 
ATOM   10334 N N   . PRO C 1 324 ? -13.024 58.127  -12.445 1.00 58.87  ? 324 PRO C N   1 
ATOM   10335 C CA  . PRO C 1 324 ? -12.010 58.402  -13.465 1.00 60.25  ? 324 PRO C CA  1 
ATOM   10336 C C   . PRO C 1 324 ? -11.108 59.616  -13.223 1.00 59.77  ? 324 PRO C C   1 
ATOM   10337 O O   . PRO C 1 324 ? -9.933  59.588  -13.600 1.00 58.68  ? 324 PRO C O   1 
ATOM   10338 C CB  . PRO C 1 324 ? -12.867 58.571  -14.739 1.00 63.70  ? 324 PRO C CB  1 
ATOM   10339 C CG  . PRO C 1 324 ? -14.117 57.767  -14.469 1.00 57.76  ? 324 PRO C CG  1 
ATOM   10340 C CD  . PRO C 1 324 ? -14.386 58.038  -13.005 1.00 59.35  ? 324 PRO C CD  1 
ATOM   10341 N N   . ILE C 1 325 ? -11.639 60.667  -12.574 1.00 56.26  ? 325 ILE C N   1 
ATOM   10342 C CA  . ILE C 1 325 ? -10.876 61.888  -12.325 1.00 55.04  ? 325 ILE C CA  1 
ATOM   10343 C C   . ILE C 1 325 ? -9.826  61.626  -11.242 1.00 54.69  ? 325 ILE C C   1 
ATOM   10344 O O   . ILE C 1 325 ? -8.655  62.003  -11.402 1.00 55.33  ? 325 ILE C O   1 
ATOM   10345 C CB  . ILE C 1 325 ? -11.798 63.070  -11.951 1.00 62.19  ? 325 ILE C CB  1 
ATOM   10346 C CG1 . ILE C 1 325 ? -12.873 63.329  -13.021 1.00 61.90  ? 325 ILE C CG1 1 
ATOM   10347 C CG2 . ILE C 1 325 ? -10.978 64.335  -11.668 1.00 60.75  ? 325 ILE C CG2 1 
ATOM   10348 C CD1 . ILE C 1 325 ? -13.963 64.299  -12.591 1.00 62.83  ? 325 ILE C CD1 1 
ATOM   10349 N N   . VAL C 1 326 ? -10.271 60.980  -10.150 1.00 51.93  ? 326 VAL C N   1 
ATOM   10350 C CA  . VAL C 1 326 ? -9.425  60.606  -9.024  1.00 49.38  ? 326 VAL C CA  1 
ATOM   10351 C C   . VAL C 1 326 ? -8.336  59.652  -9.519  1.00 53.44  ? 326 VAL C C   1 
ATOM   10352 O O   . VAL C 1 326 ? -7.162  59.781  -9.148  1.00 50.14  ? 326 VAL C O   1 
ATOM   10353 C CB  . VAL C 1 326 ? -10.264 59.979  -7.891  1.00 48.52  ? 326 VAL C CB  1 
ATOM   10354 C CG1 . VAL C 1 326 ? -9.389  59.357  -6.806  1.00 52.57  ? 326 VAL C CG1 1 
ATOM   10355 C CG2 . VAL C 1 326 ? -11.252 60.970  -7.276  1.00 47.49  ? 326 VAL C CG2 1 
ATOM   10356 N N   . GLN C 1 327 ? -8.742  58.711  -10.381 1.00 53.46  ? 327 GLN C N   1 
ATOM   10357 C CA  . GLN C 1 327 ? -7.808  57.803  -11.029 1.00 59.15  ? 327 GLN C CA  1 
ATOM   10358 C C   . GLN C 1 327 ? -6.711  58.635  -11.705 1.00 57.08  ? 327 GLN C C   1 
ATOM   10359 O O   . GLN C 1 327 ? -5.525  58.449  -11.428 1.00 50.67  ? 327 GLN C O   1 
ATOM   10360 C CB  . GLN C 1 327 ? -8.582  56.888  -11.988 1.00 59.40  ? 327 GLN C CB  1 
ATOM   10361 C CG  . GLN C 1 327 ? -8.086  55.449  -12.073 1.00 65.83  ? 327 GLN C CG  1 
ATOM   10362 C CD  . GLN C 1 327 ? -8.751  54.531  -11.066 1.00 83.09  ? 327 GLN C CD  1 
ATOM   10363 O OE1 . GLN C 1 327 ? -9.970  54.324  -11.097 1.00 99.26  ? 327 GLN C OE1 1 
ATOM   10364 N NE2 . GLN C 1 327 ? -7.968  53.954  -10.162 1.00 81.09  ? 327 GLN C NE2 1 
ATOM   10365 N N   . SER C 1 328 ? -7.112  59.591  -12.562 1.00 55.56  ? 328 SER C N   1 
ATOM   10366 C CA  . SER C 1 328 ? -6.149  60.405  -13.300 1.00 59.24  ? 328 SER C CA  1 
ATOM   10367 C C   . SER C 1 328 ? -5.217  61.169  -12.362 1.00 46.86  ? 328 SER C C   1 
ATOM   10368 O O   . SER C 1 328 ? -4.022  61.287  -12.636 1.00 45.75  ? 328 SER C O   1 
ATOM   10369 C CB  . SER C 1 328 ? -6.817  61.372  -14.252 1.00 58.20  ? 328 SER C CB  1 
ATOM   10370 O OG  . SER C 1 328 ? -7.774  60.691  -15.041 1.00 71.64  ? 328 SER C OG  1 
ATOM   10371 N N   . GLN C 1 329 ? -5.784  61.751  -11.304 1.00 45.35  ? 329 GLN C N   1 
ATOM   10372 C CA  . GLN C 1 329 ? -5.005  62.543  -10.365 1.00 49.79  ? 329 GLN C CA  1 
ATOM   10373 C C   . GLN C 1 329 ? -3.987  61.649  -9.655  1.00 49.42  ? 329 GLN C C   1 
ATOM   10374 O O   . GLN C 1 329 ? -2.835  62.053  -9.510  1.00 48.50  ? 329 GLN C O   1 
ATOM   10375 C CB  . GLN C 1 329 ? -5.930  63.284  -9.399  1.00 48.12  ? 329 GLN C CB  1 
ATOM   10376 C CG  . GLN C 1 329 ? -6.710  64.424  -10.049 1.00 52.39  ? 329 GLN C CG  1 
ATOM   10377 C CD  . GLN C 1 329 ? -8.014  64.767  -9.346  1.00 53.00  ? 329 GLN C CD  1 
ATOM   10378 O OE1 . GLN C 1 329 ? -8.626  63.947  -8.650  1.00 51.00  ? 329 GLN C OE1 1 
ATOM   10379 N NE2 . GLN C 1 329 ? -8.466  65.998  -9.534  1.00 51.64  ? 329 GLN C NE2 1 
ATOM   10380 N N   . LEU C 1 330 ? -4.431  60.448  -9.223  1.00 48.00  ? 330 LEU C N   1 
ATOM   10381 C CA  . LEU C 1 330 ? -3.581  59.466  -8.555  1.00 45.46  ? 330 LEU C CA  1 
ATOM   10382 C C   . LEU C 1 330 ? -2.440  59.085  -9.485  1.00 43.74  ? 330 LEU C C   1 
ATOM   10383 O O   . LEU C 1 330 ? -1.268  59.072  -9.077  1.00 38.43  ? 330 LEU C O   1 
ATOM   10384 C CB  . LEU C 1 330 ? -4.370  58.226  -8.131  1.00 48.92  ? 330 LEU C CB  1 
ATOM   10385 C CG  . LEU C 1 330 ? -5.238  58.387  -6.877  1.00 49.31  ? 330 LEU C CG  1 
ATOM   10386 C CD1 . LEU C 1 330 ? -6.209  57.253  -6.876  1.00 50.17  ? 330 LEU C CD1 1 
ATOM   10387 C CD2 . LEU C 1 330 ? -4.432  58.430  -5.562  1.00 48.43  ? 330 LEU C CD2 1 
ATOM   10388 N N   . ALA C 1 331 ? -2.802  58.854  -10.755 1.00 41.74  ? 331 ALA C N   1 
ATOM   10389 C CA  . ALA C 1 331 ? -1.822  58.580  -11.801 1.00 48.45  ? 331 ALA C CA  1 
ATOM   10390 C C   . ALA C 1 331 ? -0.742  59.668  -11.870 1.00 46.15  ? 331 ALA C C   1 
ATOM   10391 O O   . ALA C 1 331 ? 0.431   59.327  -11.967 1.00 46.57  ? 331 ALA C O   1 
ATOM   10392 C CB  . ALA C 1 331 ? -2.519  58.359  -13.137 1.00 51.97  ? 331 ALA C CB  1 
ATOM   10393 N N   . ASP C 1 332 ? -1.102  60.962  -11.773 1.00 51.15  ? 332 ASP C N   1 
ATOM   10394 C CA  . ASP C 1 332 ? -0.093  62.028  -11.772 1.00 52.27  ? 332 ASP C CA  1 
ATOM   10395 C C   . ASP C 1 332 ? 0.706   62.028  -10.461 1.00 44.79  ? 332 ASP C C   1 
ATOM   10396 O O   . ASP C 1 332 ? 1.866   62.421  -10.448 1.00 43.06  ? 332 ASP C O   1 
ATOM   10397 C CB  . ASP C 1 332 ? -0.655  63.415  -12.093 1.00 56.41  ? 332 ASP C CB  1 
ATOM   10398 C CG  . ASP C 1 332 ? -1.436  63.546  -13.401 1.00 63.72  ? 332 ASP C CG  1 
ATOM   10399 O OD1 . ASP C 1 332 ? -0.974  63.014  -14.433 1.00 50.22  ? 332 ASP C OD1 1 
ATOM   10400 O OD2 . ASP C 1 332 ? -2.528  64.161  -13.379 1.00 74.99  ? 332 ASP C OD2 1 
ATOM   10401 N N   . LEU C 1 333 ? 0.131   61.564  -9.344  1.00 44.64  ? 333 LEU C N   1 
ATOM   10402 C CA  . LEU C 1 333 ? 0.935   61.402  -8.133  1.00 45.30  ? 333 LEU C CA  1 
ATOM   10403 C C   . LEU C 1 333 ? 1.960   60.281  -8.322  1.00 47.71  ? 333 LEU C C   1 
ATOM   10404 O O   . LEU C 1 333 ? 3.126   60.423  -7.936  1.00 45.23  ? 333 LEU C O   1 
ATOM   10405 C CB  . LEU C 1 333 ? 0.054   61.171  -6.904  1.00 43.79  ? 333 LEU C CB  1 
ATOM   10406 C CG  . LEU C 1 333 ? -0.832  62.350  -6.488  1.00 44.52  ? 333 LEU C CG  1 
ATOM   10407 C CD1 . LEU C 1 333 ? -1.738  62.018  -5.295  1.00 44.96  ? 333 LEU C CD1 1 
ATOM   10408 C CD2 . LEU C 1 333 ? 0.030   63.587  -6.184  1.00 43.79  ? 333 LEU C CD2 1 
ATOM   10409 N N   . VAL C 1 334 ? 1.528   59.171  -8.949  1.00 49.44  ? 334 VAL C N   1 
ATOM   10410 C CA  . VAL C 1 334 ? 2.442   58.079  -9.244  1.00 51.40  ? 334 VAL C CA  1 
ATOM   10411 C C   . VAL C 1 334 ? 3.596   58.628  -10.083 1.00 49.90  ? 334 VAL C C   1 
ATOM   10412 O O   . VAL C 1 334 ? 4.767   58.376  -9.779  1.00 45.02  ? 334 VAL C O   1 
ATOM   10413 C CB  . VAL C 1 334 ? 1.750   56.889  -9.942  1.00 52.64  ? 334 VAL C CB  1 
ATOM   10414 C CG1 . VAL C 1 334 ? 2.771   55.899  -10.510 1.00 54.35  ? 334 VAL C CG1 1 
ATOM   10415 C CG2 . VAL C 1 334 ? 0.749   56.179  -9.028  1.00 49.12  ? 334 VAL C CG2 1 
ATOM   10416 N N   . ARG C 1 335 ? 3.242   59.405  -11.125 1.00 54.86  ? 335 ARG C N   1 
ATOM   10417 C CA  . ARG C 1 335 ? 4.206   59.952  -12.072 1.00 48.80  ? 335 ARG C CA  1 
ATOM   10418 C C   . ARG C 1 335 ? 5.167   60.918  -11.380 1.00 44.19  ? 335 ARG C C   1 
ATOM   10419 O O   . ARG C 1 335 ? 6.362   60.948  -11.702 1.00 44.01  ? 335 ARG C O   1 
ATOM   10420 C CB  . ARG C 1 335 ? 3.537   60.619  -13.273 1.00 47.58  ? 335 ARG C CB  1 
ATOM   10421 C CG  . ARG C 1 335 ? 4.581   61.195  -14.220 1.00 54.08  ? 335 ARG C CG  1 
ATOM   10422 C CD  . ARG C 1 335 ? 4.068   61.297  -15.635 1.00 54.85  ? 335 ARG C CD  1 
ATOM   10423 N NE  . ARG C 1 335 ? 2.772   61.980  -15.611 1.00 52.24  ? 335 ARG C NE  1 
ATOM   10424 C CZ  . ARG C 1 335 ? 2.644   63.272  -15.825 1.00 49.04  ? 335 ARG C CZ  1 
ATOM   10425 N NH1 . ARG C 1 335 ? 3.715   64.030  -15.941 1.00 47.37  ? 335 ARG C NH1 1 
ATOM   10426 N NH2 . ARG C 1 335 ? 1.441   63.795  -15.899 1.00 51.47  ? 335 ARG C NH2 1 
ATOM   10427 N N   . PHE C 1 336 ? 4.659   61.687  -10.412 1.00 46.45  ? 336 PHE C N   1 
ATOM   10428 C CA  . PHE C 1 336 ? 5.518   62.625  -9.690  1.00 52.53  ? 336 PHE C CA  1 
ATOM   10429 C C   . PHE C 1 336 ? 6.597   61.824  -8.945  1.00 50.99  ? 336 PHE C C   1 
ATOM   10430 O O   . PHE C 1 336 ? 7.775   62.189  -8.977  1.00 48.34  ? 336 PHE C O   1 
ATOM   10431 C CB  . PHE C 1 336 ? 4.634   63.542  -8.827  1.00 48.18  ? 336 PHE C CB  1 
ATOM   10432 C CG  . PHE C 1 336 ? 5.391   64.440  -7.857  1.00 51.38  ? 336 PHE C CG  1 
ATOM   10433 C CD1 . PHE C 1 336 ? 6.140   65.521  -8.318  1.00 50.75  ? 336 PHE C CD1 1 
ATOM   10434 C CD2 . PHE C 1 336 ? 5.337   64.214  -6.483  1.00 49.33  ? 336 PHE C CD2 1 
ATOM   10435 C CE1 . PHE C 1 336 ? 6.809   66.352  -7.435  1.00 48.60  ? 336 PHE C CE1 1 
ATOM   10436 C CE2 . PHE C 1 336 ? 6.027   65.039  -5.607  1.00 51.18  ? 336 PHE C CE2 1 
ATOM   10437 C CZ  . PHE C 1 336 ? 6.759   66.107  -6.087  1.00 50.62  ? 336 PHE C CZ  1 
ATOM   10438 N N   . ARG C 1 337 ? 6.175   60.707  -8.317  1.00 45.06  ? 337 ARG C N   1 
ATOM   10439 C CA  . ARG C 1 337 ? 7.068   59.811  -7.606  1.00 45.74  ? 337 ARG C CA  1 
ATOM   10440 C C   . ARG C 1 337 ? 8.107   59.233  -8.556  1.00 45.76  ? 337 ARG C C   1 
ATOM   10441 O O   . ARG C 1 337 ? 9.320   59.304  -8.290  1.00 46.52  ? 337 ARG C O   1 
ATOM   10442 C CB  . ARG C 1 337 ? 6.282   58.698  -6.899  1.00 52.93  ? 337 ARG C CB  1 
ATOM   10443 C CG  . ARG C 1 337 ? 7.102   57.738  -6.045  1.00 55.50  ? 337 ARG C CG  1 
ATOM   10444 C CD  . ARG C 1 337 ? 7.677   56.553  -6.827  1.00 53.61  ? 337 ARG C CD  1 
ATOM   10445 N NE  . ARG C 1 337 ? 8.514   55.697  -5.977  1.00 60.75  ? 337 ARG C NE  1 
ATOM   10446 C CZ  . ARG C 1 337 ? 8.444   54.362  -5.853  1.00 65.44  ? 337 ARG C CZ  1 
ATOM   10447 N NH1 . ARG C 1 337 ? 7.695   53.617  -6.664  1.00 65.71  ? 337 ARG C NH1 1 
ATOM   10448 N NH2 . ARG C 1 337 ? 9.151   53.768  -4.902  1.00 60.66  ? 337 ARG C NH2 1 
ATOM   10449 N N   . GLU C 1 338 ? 7.635   58.667  -9.671  1.00 45.17  ? 338 GLU C N   1 
ATOM   10450 C CA  . GLU C 1 338 ? 8.556   57.982  -10.570 1.00 47.79  ? 338 GLU C CA  1 
ATOM   10451 C C   . GLU C 1 338 ? 9.518   58.979  -11.218 1.00 46.08  ? 338 GLU C C   1 
ATOM   10452 O O   . GLU C 1 338 ? 10.651  58.607  -11.533 1.00 49.49  ? 338 GLU C O   1 
ATOM   10453 C CB  . GLU C 1 338 ? 7.822   57.099  -11.585 1.00 48.98  ? 338 GLU C CB  1 
ATOM   10454 C CG  . GLU C 1 338 ? 7.019   55.965  -10.945 1.00 48.22  ? 338 GLU C CG  1 
ATOM   10455 C CD  . GLU C 1 338 ? 7.812   54.956  -10.125 1.00 53.17  ? 338 GLU C CD  1 
ATOM   10456 O OE1 . GLU C 1 338 ? 9.073   55.008  -10.115 1.00 58.12  ? 338 GLU C OE1 1 
ATOM   10457 O OE2 . GLU C 1 338 ? 7.142   54.108  -9.481  1.00 51.77  ? 338 GLU C OE2 1 
ATOM   10458 N N   . THR C 1 339 ? 9.079   60.235  -11.418 1.00 41.20  ? 339 THR C N   1 
ATOM   10459 C CA  . THR C 1 339 ? 9.954   61.262  -11.970 1.00 43.81  ? 339 THR C CA  1 
ATOM   10460 C C   . THR C 1 339 ? 11.144  61.498  -11.032 1.00 40.72  ? 339 THR C C   1 
ATOM   10461 O O   . THR C 1 339 ? 12.301  61.481  -11.459 1.00 42.21  ? 339 THR C O   1 
ATOM   10462 C CB  . THR C 1 339 ? 9.164   62.552  -12.225 1.00 46.18  ? 339 THR C CB  1 
ATOM   10463 O OG1 . THR C 1 339 ? 8.074   62.327  -13.122 1.00 46.13  ? 339 THR C OG1 1 
ATOM   10464 C CG2 . THR C 1 339 ? 10.045  63.594  -12.874 1.00 45.81  ? 339 THR C CG2 1 
ATOM   10465 N N   . CYS C 1 340 ? 10.880  61.685  -9.734  1.00 43.61  ? 340 CYS C N   1 
ATOM   10466 C CA  . CYS C 1 340 ? 11.958  61.877  -8.757  1.00 49.36  ? 340 CYS C CA  1 
ATOM   10467 C C   . CYS C 1 340 ? 12.888  60.657  -8.733  1.00 50.37  ? 340 CYS C C   1 
ATOM   10468 O O   . CYS C 1 340 ? 14.107  60.785  -8.756  1.00 45.64  ? 340 CYS C O   1 
ATOM   10469 C CB  . CYS C 1 340 ? 11.406  62.163  -7.363  1.00 49.79  ? 340 CYS C CB  1 
ATOM   10470 S SG  . CYS C 1 340 ? 10.361  63.646  -7.281  1.00 48.60  ? 340 CYS C SG  1 
ATOM   10471 N N   . LYS C 1 341 ? 12.301  59.458  -8.759  1.00 50.23  ? 341 LYS C N   1 
ATOM   10472 C CA  . LYS C 1 341 ? 13.073  58.223  -8.739  1.00 55.56  ? 341 LYS C CA  1 
ATOM   10473 C C   . LYS C 1 341 ? 13.982  58.107  -9.976  1.00 54.92  ? 341 LYS C C   1 
ATOM   10474 O O   . LYS C 1 341 ? 15.173  57.779  -9.869  1.00 46.66  ? 341 LYS C O   1 
ATOM   10475 C CB  . LYS C 1 341 ? 12.031  57.119  -8.525  1.00 54.20  ? 341 LYS C CB  1 
ATOM   10476 C CG  . LYS C 1 341 ? 12.620  55.752  -8.381  1.00 58.57  ? 341 LYS C CG  1 
ATOM   10477 C CD  . LYS C 1 341 ? 11.799  54.815  -7.516  1.00 56.06  ? 341 LYS C CD  1 
ATOM   10478 C CE  . LYS C 1 341 ? 12.573  53.544  -7.399  1.00 56.96  ? 341 LYS C CE  1 
ATOM   10479 N NZ  . LYS C 1 341 ? 11.648  52.419  -7.286  1.00 56.66  ? 341 LYS C NZ  1 
ATOM   10480 N N   . ALA C 1 342 ? 13.428  58.414  -11.154 1.00 49.62  ? 342 ALA C N   1 
ATOM   10481 C CA  . ALA C 1 342 ? 14.167  58.353  -12.408 1.00 50.00  ? 342 ALA C CA  1 
ATOM   10482 C C   . ALA C 1 342 ? 15.375  59.278  -12.375 1.00 53.39  ? 342 ALA C C   1 
ATOM   10483 O O   . ALA C 1 342 ? 16.439  58.919  -12.881 1.00 56.50  ? 342 ALA C O   1 
ATOM   10484 C CB  . ALA C 1 342 ? 13.266  58.705  -13.578 1.00 52.01  ? 342 ALA C CB  1 
ATOM   10485 N N   . PHE C 1 343 ? 15.201  60.483  -11.824 1.00 51.29  ? 343 PHE C N   1 
ATOM   10486 C CA  . PHE C 1 343 ? 16.321  61.409  -11.751 1.00 51.02  ? 343 PHE C CA  1 
ATOM   10487 C C   . PHE C 1 343 ? 17.414  60.854  -10.829 1.00 50.88  ? 343 PHE C C   1 
ATOM   10488 O O   . PHE C 1 343 ? 18.608  60.976  -11.123 1.00 52.13  ? 343 PHE C O   1 
ATOM   10489 C CB  . PHE C 1 343 ? 15.863  62.798  -11.293 1.00 48.51  ? 343 PHE C CB  1 
ATOM   10490 C CG  . PHE C 1 343 ? 15.440  63.758  -12.390 1.00 44.10  ? 343 PHE C CG  1 
ATOM   10491 C CD1 . PHE C 1 343 ? 16.386  64.284  -13.270 1.00 46.55  ? 343 PHE C CD1 1 
ATOM   10492 C CD2 . PHE C 1 343 ? 14.113  64.164  -12.512 1.00 42.32  ? 343 PHE C CD2 1 
ATOM   10493 C CE1 . PHE C 1 343 ? 15.999  65.181  -14.260 1.00 50.89  ? 343 PHE C CE1 1 
ATOM   10494 C CE2 . PHE C 1 343 ? 13.738  65.092  -13.474 1.00 48.16  ? 343 PHE C CE2 1 
ATOM   10495 C CZ  . PHE C 1 343 ? 14.679  65.605  -14.342 1.00 47.40  ? 343 PHE C CZ  1 
ATOM   10496 N N   . ALA C 1 344 ? 17.006  60.266  -9.698  1.00 53.29  ? 344 ALA C N   1 
ATOM   10497 C CA  . ALA C 1 344 ? 17.949  59.639  -8.780  1.00 56.76  ? 344 ALA C CA  1 
ATOM   10498 C C   . ALA C 1 344 ? 18.721  58.509  -9.477  1.00 56.57  ? 344 ALA C C   1 
ATOM   10499 O O   . ALA C 1 344 ? 19.947  58.437  -9.366  1.00 52.23  ? 344 ALA C O   1 
ATOM   10500 C CB  . ALA C 1 344 ? 17.218  59.148  -7.543  1.00 54.96  ? 344 ALA C CB  1 
ATOM   10501 N N   . ILE C 1 345 ? 18.003  57.650  -10.219 1.00 53.03  ? 345 ILE C N   1 
ATOM   10502 C CA  . ILE C 1 345 ? 18.628  56.572  -10.976 1.00 53.66  ? 345 ILE C CA  1 
ATOM   10503 C C   . ILE C 1 345 ? 19.589  57.120  -12.035 1.00 54.78  ? 345 ILE C C   1 
ATOM   10504 O O   . ILE C 1 345 ? 20.712  56.621  -12.160 1.00 54.34  ? 345 ILE C O   1 
ATOM   10505 C CB  . ILE C 1 345 ? 17.569  55.636  -11.575 1.00 55.17  ? 345 ILE C CB  1 
ATOM   10506 C CG1 . ILE C 1 345 ? 16.969  54.761  -10.484 1.00 54.75  ? 345 ILE C CG1 1 
ATOM   10507 C CG2 . ILE C 1 345 ? 18.165  54.793  -12.706 1.00 59.87  ? 345 ILE C CG2 1 
ATOM   10508 C CD1 . ILE C 1 345 ? 15.694  54.047  -10.884 1.00 58.17  ? 345 ILE C CD1 1 
ATOM   10509 N N   . ALA C 1 346 ? 19.168  58.157  -12.780 1.00 58.33  ? 346 ALA C N   1 
ATOM   10510 C CA  . ALA C 1 346 ? 20.005  58.733  -13.830 1.00 51.29  ? 346 ALA C CA  1 
ATOM   10511 C C   . ALA C 1 346 ? 21.229  59.430  -13.226 1.00 51.51  ? 346 ALA C C   1 
ATOM   10512 O O   . ALA C 1 346 ? 22.318  59.390  -13.802 1.00 51.22  ? 346 ALA C O   1 
ATOM   10513 C CB  . ALA C 1 346 ? 19.191  59.658  -14.726 1.00 47.94  ? 346 ALA C CB  1 
ATOM   10514 N N   . ALA C 1 347 ? 21.063  60.062  -12.056 1.00 49.39  ? 347 ALA C N   1 
ATOM   10515 C CA  . ALA C 1 347 ? 22.172  60.758  -11.426 1.00 46.17  ? 347 ALA C CA  1 
ATOM   10516 C C   . ALA C 1 347 ? 23.277  59.759  -11.101 1.00 53.70  ? 347 ALA C C   1 
ATOM   10517 O O   . ALA C 1 347 ? 24.437  59.968  -11.449 1.00 58.67  ? 347 ALA C O   1 
ATOM   10518 C CB  . ALA C 1 347 ? 21.697  61.484  -10.200 1.00 41.78  ? 347 ALA C CB  1 
ATOM   10519 N N   . GLU C 1 348 ? 22.895  58.683  -10.414 1.00 56.84  ? 348 GLU C N   1 
ATOM   10520 C CA  . GLU C 1 348 ? 23.821  57.642  -10.005 1.00 53.80  ? 348 GLU C CA  1 
ATOM   10521 C C   . GLU C 1 348 ? 24.412  56.974  -11.239 1.00 56.61  ? 348 GLU C C   1 
ATOM   10522 O O   . GLU C 1 348 ? 25.629  56.821  -11.345 1.00 60.23  ? 348 GLU C O   1 
ATOM   10523 C CB  . GLU C 1 348 ? 23.067  56.608  -9.181  1.00 50.00  ? 348 GLU C CB  1 
ATOM   10524 C CG  . GLU C 1 348 ? 23.985  55.629  -8.469  1.00 56.36  ? 348 GLU C CG  1 
ATOM   10525 C CD  . GLU C 1 348 ? 23.190  54.783  -7.503  1.00 61.59  ? 348 GLU C CD  1 
ATOM   10526 O OE1 . GLU C 1 348 ? 22.738  55.345  -6.464  1.00 56.31  ? 348 GLU C OE1 1 
ATOM   10527 O OE2 . GLU C 1 348 ? 22.995  53.585  -7.836  1.00 59.74  ? 348 GLU C OE2 1 
ATOM   10528 N N   . GLU C 1 349 ? 23.546  56.645  -12.200 1.00 55.40  ? 349 GLU C N   1 
ATOM   10529 C CA  . GLU C 1 349 ? 23.980  55.899  -13.374 1.00 60.74  ? 349 GLU C CA  1 
ATOM   10530 C C   . GLU C 1 349 ? 24.984  56.666  -14.248 1.00 58.68  ? 349 GLU C C   1 
ATOM   10531 O O   . GLU C 1 349 ? 25.726  56.030  -14.987 1.00 57.20  ? 349 GLU C O   1 
ATOM   10532 C CB  . GLU C 1 349 ? 22.753  55.478  -14.178 1.00 62.13  ? 349 GLU C CB  1 
ATOM   10533 C CG  . GLU C 1 349 ? 23.106  54.697  -15.438 1.00 78.41  ? 349 GLU C CG  1 
ATOM   10534 C CD  . GLU C 1 349 ? 23.923  53.439  -15.184 1.00 87.88  ? 349 GLU C CD  1 
ATOM   10535 O OE1 . GLU C 1 349 ? 23.959  52.923  -14.034 1.00 89.57  ? 349 GLU C OE1 1 
ATOM   10536 O OE2 . GLU C 1 349 ? 24.539  52.989  -16.173 1.00 79.65  ? 349 GLU C OE2 1 
ATOM   10537 N N   . THR C 1 350 ? 25.004  58.013  -14.188 1.00 57.42  ? 350 THR C N   1 
ATOM   10538 C CA  . THR C 1 350 ? 25.890  58.830  -15.016 1.00 61.02  ? 350 THR C CA  1 
ATOM   10539 C C   . THR C 1 350 ? 26.944  59.559  -14.162 1.00 62.42  ? 350 THR C C   1 
ATOM   10540 O O   . THR C 1 350 ? 27.569  60.534  -14.612 1.00 59.35  ? 350 THR C O   1 
ATOM   10541 C CB  . THR C 1 350 ? 25.042  59.796  -15.859 1.00 63.75  ? 350 THR C CB  1 
ATOM   10542 O OG1 . THR C 1 350 ? 24.271  60.618  -14.980 1.00 54.55  ? 350 THR C OG1 1 
ATOM   10543 C CG2 . THR C 1 350 ? 24.129  59.061  -16.830 1.00 60.14  ? 350 THR C CG2 1 
ATOM   10544 N N   . GLY C 1 351 ? 27.177  59.053  -12.937 1.00 64.85  ? 351 GLY C N   1 
ATOM   10545 C CA  . GLY C 1 351 ? 28.208  59.579  -12.054 1.00 67.94  ? 351 GLY C CA  1 
ATOM   10546 C C   . GLY C 1 351 ? 29.622  59.310  -12.580 1.00 66.32  ? 351 GLY C C   1 
ATOM   10547 O O   . GLY C 1 351 ? 29.802  58.781  -13.671 1.00 63.94  ? 351 GLY C O   1 
ATOM   10548 N N   . PHE C 1 352 ? 30.623  59.679  -11.776 1.00 72.66  ? 352 PHE C N   1 
ATOM   10549 C CA  . PHE C 1 352 ? 32.026  59.665  -12.173 1.00 83.44  ? 352 PHE C CA  1 
ATOM   10550 C C   . PHE C 1 352 ? 32.868  59.804  -10.904 1.00 73.92  ? 352 PHE C C   1 
ATOM   10551 O O   . PHE C 1 352 ? 32.385  60.322  -9.898  1.00 66.50  ? 352 PHE C O   1 
ATOM   10552 C CB  . PHE C 1 352 ? 32.300  60.780  -13.194 1.00 90.98  ? 352 PHE C CB  1 
ATOM   10553 C CG  . PHE C 1 352 ? 31.858  62.171  -12.742 1.00 113.39 ? 352 PHE C CG  1 
ATOM   10554 C CD1 . PHE C 1 352 ? 30.561  62.629  -12.990 1.00 123.62 ? 352 PHE C CD1 1 
ATOM   10555 C CD2 . PHE C 1 352 ? 32.729  63.011  -12.047 1.00 118.85 ? 352 PHE C CD2 1 
ATOM   10556 C CE1 . PHE C 1 352 ? 30.150  63.884  -12.558 1.00 127.15 ? 352 PHE C CE1 1 
ATOM   10557 C CE2 . PHE C 1 352 ? 32.314  64.267  -11.620 1.00 127.46 ? 352 PHE C CE2 1 
ATOM   10558 C CZ  . PHE C 1 352 ? 31.027  64.703  -11.878 1.00 130.85 ? 352 PHE C CZ  1 
ATOM   10559 N N   . THR C 1 353 ? 34.119  59.328  -10.936 1.00 75.50  ? 353 THR C N   1 
ATOM   10560 C CA  . THR C 1 353 ? 35.015  59.494  -9.798  1.00 76.72  ? 353 THR C CA  1 
ATOM   10561 C C   . THR C 1 353 ? 35.661  60.877  -9.893  1.00 72.20  ? 353 THR C C   1 
ATOM   10562 O O   . THR C 1 353 ? 35.924  61.352  -10.996 1.00 71.75  ? 353 THR C O   1 
ATOM   10563 C CB  . THR C 1 353 ? 36.033  58.350  -9.723  1.00 75.36  ? 353 THR C CB  1 
ATOM   10564 O OG1 . THR C 1 353 ? 36.590  58.204  -11.024 1.00 72.22  ? 353 THR C OG1 1 
ATOM   10565 C CG2 . THR C 1 353 ? 35.411  57.024  -9.311  1.00 72.08  ? 353 THR C CG2 1 
ATOM   10566 N N   . THR C 1 354 ? 35.857  61.540  -8.740  1.00 75.94  ? 354 THR C N   1 
ATOM   10567 C CA  . THR C 1 354 ? 36.544  62.828  -8.682  1.00 83.68  ? 354 THR C CA  1 
ATOM   10568 C C   . THR C 1 354 ? 38.052  62.586  -8.807  1.00 86.39  ? 354 THR C C   1 
ATOM   10569 O O   . THR C 1 354 ? 38.495  61.449  -8.977  1.00 74.13  ? 354 THR C O   1 
ATOM   10570 C CB  . THR C 1 354 ? 36.188  63.597  -7.402  1.00 84.22  ? 354 THR C CB  1 
ATOM   10571 O OG1 . THR C 1 354 ? 36.306  62.704  -6.301  1.00 85.35  ? 354 THR C OG1 1 
ATOM   10572 C CG2 . THR C 1 354 ? 34.770  64.142  -7.395  1.00 83.73  ? 354 THR C CG2 1 
ATOM   10573 N N   . ALA C 1 355 ? 38.840  63.667  -8.737  1.00 93.51  ? 355 ALA C N   1 
ATOM   10574 C CA  . ALA C 1 355 ? 40.293  63.568  -8.703  1.00 94.13  ? 355 ALA C CA  1 
ATOM   10575 C C   . ALA C 1 355 ? 40.760  62.593  -7.615  1.00 90.86  ? 355 ALA C C   1 
ATOM   10576 O O   . ALA C 1 355 ? 41.733  61.874  -7.826  1.00 89.09  ? 355 ALA C O   1 
ATOM   10577 C CB  . ALA C 1 355 ? 40.899  64.947  -8.516  1.00 94.51  ? 355 ALA C CB  1 
ATOM   10578 N N   . GLY C 1 356 ? 40.050  62.536  -6.473  1.00 82.49  ? 356 GLY C N   1 
ATOM   10579 C CA  . GLY C 1 356 ? 40.497  61.773  -5.311  1.00 80.75  ? 356 GLY C CA  1 
ATOM   10580 C C   . GLY C 1 356 ? 39.944  60.345  -5.217  1.00 75.89  ? 356 GLY C C   1 
ATOM   10581 O O   . GLY C 1 356 ? 40.244  59.638  -4.255  1.00 66.78  ? 356 GLY C O   1 
ATOM   10582 N N   . GLY C 1 357 ? 39.141  59.918  -6.202  1.00 78.32  ? 357 GLY C N   1 
ATOM   10583 C CA  . GLY C 1 357 ? 38.607  58.562  -6.244  1.00 72.21  ? 357 GLY C CA  1 
ATOM   10584 C C   . GLY C 1 357 ? 37.230  58.450  -5.582  1.00 71.44  ? 357 GLY C C   1 
ATOM   10585 O O   . GLY C 1 357 ? 36.747  57.343  -5.345  1.00 70.79  ? 357 GLY C O   1 
ATOM   10586 N N   . LEU C 1 358 ? 36.601  59.596  -5.281  1.00 71.53  ? 358 LEU C N   1 
ATOM   10587 C CA  . LEU C 1 358 ? 35.231  59.628  -4.783  1.00 74.04  ? 358 LEU C CA  1 
ATOM   10588 C C   . LEU C 1 358 ? 34.271  59.484  -5.964  1.00 67.10  ? 358 LEU C C   1 
ATOM   10589 O O   . LEU C 1 358 ? 34.420  60.188  -6.958  1.00 69.44  ? 358 LEU C O   1 
ATOM   10590 C CB  . LEU C 1 358 ? 35.029  60.956  -4.053  1.00 78.58  ? 358 LEU C CB  1 
ATOM   10591 C CG  . LEU C 1 358 ? 33.902  61.026  -3.020  1.00 84.38  ? 358 LEU C CG  1 
ATOM   10592 C CD1 . LEU C 1 358 ? 34.232  60.145  -1.824  1.00 88.47  ? 358 LEU C CD1 1 
ATOM   10593 C CD2 . LEU C 1 358 ? 33.653  62.472  -2.584  1.00 79.61  ? 358 LEU C CD2 1 
ATOM   10594 N N   . PHE C 1 359 ? 33.314  58.549  -5.878  1.00 69.77  ? 359 PHE C N   1 
ATOM   10595 C CA  . PHE C 1 359 ? 32.302  58.394  -6.917  1.00 70.50  ? 359 PHE C CA  1 
ATOM   10596 C C   . PHE C 1 359 ? 31.123  59.306  -6.588  1.00 71.29  ? 359 PHE C C   1 
ATOM   10597 O O   . PHE C 1 359 ? 30.487  59.150  -5.541  1.00 65.12  ? 359 PHE C O   1 
ATOM   10598 C CB  . PHE C 1 359 ? 31.786  56.967  -7.120  1.00 70.60  ? 359 PHE C CB  1 
ATOM   10599 C CG  . PHE C 1 359 ? 30.815  56.804  -8.287  1.00 66.77  ? 359 PHE C CG  1 
ATOM   10600 C CD1 . PHE C 1 359 ? 31.279  56.472  -9.563  1.00 65.15  ? 359 PHE C CD1 1 
ATOM   10601 C CD2 . PHE C 1 359 ? 29.443  56.973  -8.105  1.00 63.89  ? 359 PHE C CD2 1 
ATOM   10602 C CE1 . PHE C 1 359 ? 30.399  56.309  -10.627 1.00 60.71  ? 359 PHE C CE1 1 
ATOM   10603 C CE2 . PHE C 1 359 ? 28.563  56.810  -9.170  1.00 68.61  ? 359 PHE C CE2 1 
ATOM   10604 C CZ  . PHE C 1 359 ? 29.040  56.475  -10.428 1.00 66.49  ? 359 PHE C CZ  1 
ATOM   10605 N N   . LYS C 1 360 ? 30.856  60.233  -7.518  1.00 69.94  ? 360 LYS C N   1 
ATOM   10606 C CA  . LYS C 1 360 ? 29.905  61.316  -7.336  1.00 69.97  ? 360 LYS C CA  1 
ATOM   10607 C C   . LYS C 1 360 ? 28.775  61.168  -8.351  1.00 65.92  ? 360 LYS C C   1 
ATOM   10608 O O   . LYS C 1 360 ? 29.031  61.218  -9.550  1.00 58.24  ? 360 LYS C O   1 
ATOM   10609 C CB  . LYS C 1 360 ? 30.621  62.651  -7.579  1.00 71.40  ? 360 LYS C CB  1 
ATOM   10610 C CG  . LYS C 1 360 ? 29.855  63.916  -7.212  1.00 76.04  ? 360 LYS C CG  1 
ATOM   10611 C CD  . LYS C 1 360 ? 30.441  65.142  -7.904  1.00 83.01  ? 360 LYS C CD  1 
ATOM   10612 C CE  . LYS C 1 360 ? 29.817  66.426  -7.472  1.00 82.27  ? 360 LYS C CE  1 
ATOM   10613 N NZ  . LYS C 1 360 ? 30.034  66.660  -6.041  1.00 87.98  ? 360 LYS C NZ  1 
ATOM   10614 N N   . PRO C 1 361 ? 27.510  60.946  -7.918  1.00 61.11  ? 361 PRO C N   1 
ATOM   10615 C CA  . PRO C 1 361 ? 26.344  61.210  -8.762  1.00 60.68  ? 361 PRO C CA  1 
ATOM   10616 C C   . PRO C 1 361 ? 26.429  62.473  -9.616  1.00 59.05  ? 361 PRO C C   1 
ATOM   10617 O O   . PRO C 1 361 ? 27.011  63.473  -9.204  1.00 54.95  ? 361 PRO C O   1 
ATOM   10618 C CB  . PRO C 1 361 ? 25.234  61.301  -7.724  1.00 62.22  ? 361 PRO C CB  1 
ATOM   10619 C CG  . PRO C 1 361 ? 25.617  60.234  -6.724  1.00 70.74  ? 361 PRO C CG  1 
ATOM   10620 C CD  . PRO C 1 361 ? 27.137  60.340  -6.631  1.00 68.26  ? 361 PRO C CD  1 
ATOM   10621 N N   . ASN C 1 362 ? 25.856  62.385  -10.824 1.00 59.14  ? 362 ASN C N   1 
ATOM   10622 C CA  . ASN C 1 362 ? 25.775  63.494  -11.758 1.00 59.58  ? 362 ASN C CA  1 
ATOM   10623 C C   . ASN C 1 362 ? 24.844  64.573  -11.193 1.00 59.59  ? 362 ASN C C   1 
ATOM   10624 O O   . ASN C 1 362 ? 23.644  64.340  -11.019 1.00 54.11  ? 362 ASN C O   1 
ATOM   10625 C CB  . ASN C 1 362 ? 25.305  62.967  -13.105 1.00 59.59  ? 362 ASN C CB  1 
ATOM   10626 C CG  . ASN C 1 362 ? 25.492  63.948  -14.235 1.00 58.28  ? 362 ASN C CG  1 
ATOM   10627 O OD1 . ASN C 1 362 ? 25.987  65.060  -14.044 1.00 62.96  ? 362 ASN C OD1 1 
ATOM   10628 N ND2 . ASN C 1 362 ? 25.102  63.541  -15.432 1.00 63.09  ? 362 ASN C ND2 1 
ATOM   10629 N N   . ASN C 1 363 ? 25.425  65.743  -10.891 1.00 54.11  ? 363 ASN C N   1 
ATOM   10630 C CA  . ASN C 1 363 ? 24.718  66.854  -10.262 1.00 58.10  ? 363 ASN C CA  1 
ATOM   10631 C C   . ASN C 1 363 ? 23.664  67.446  -11.198 1.00 51.69  ? 363 ASN C C   1 
ATOM   10632 O O   . ASN C 1 363 ? 22.755  68.131  -10.744 1.00 52.07  ? 363 ASN C O   1 
ATOM   10633 C CB  . ASN C 1 363 ? 25.658  67.956  -9.767  1.00 65.54  ? 363 ASN C CB  1 
ATOM   10634 C CG  . ASN C 1 363 ? 26.876  68.199  -10.642 1.00 78.06  ? 363 ASN C CG  1 
ATOM   10635 O OD1 . ASN C 1 363 ? 27.295  67.340  -11.434 1.00 83.38  ? 363 ASN C OD1 1 
ATOM   10636 N ND2 . ASN C 1 363 ? 27.522  69.341  -10.447 1.00 75.00  ? 363 ASN C ND2 1 
ATOM   10637 N N   . ILE C 1 364 ? 23.793  67.218  -12.505 1.00 48.38  ? 364 ILE C N   1 
ATOM   10638 C CA  . ILE C 1 364 ? 22.803  67.706  -13.448 1.00 57.05  ? 364 ILE C CA  1 
ATOM   10639 C C   . ILE C 1 364 ? 21.472  67.013  -13.164 1.00 53.05  ? 364 ILE C C   1 
ATOM   10640 O O   . ILE C 1 364 ? 20.434  67.660  -13.054 1.00 57.24  ? 364 ILE C O   1 
ATOM   10641 C CB  . ILE C 1 364 ? 23.275  67.539  -14.908 1.00 64.26  ? 364 ILE C CB  1 
ATOM   10642 C CG1 . ILE C 1 364 ? 24.447  68.517  -15.225 1.00 67.26  ? 364 ILE C CG1 1 
ATOM   10643 C CG2 . ILE C 1 364 ? 22.097  67.710  -15.878 1.00 63.67  ? 364 ILE C CG2 1 
ATOM   10644 C CD1 . ILE C 1 364 ? 25.061  68.386  -16.617 1.00 67.97  ? 364 ILE C CD1 1 
ATOM   10645 N N   . TYR C 1 365 ? 21.502  65.697  -12.995 1.00 53.41  ? 365 TYR C N   1 
ATOM   10646 C CA  . TYR C 1 365 ? 20.274  64.967  -12.728 1.00 57.79  ? 365 TYR C CA  1 
ATOM   10647 C C   . TYR C 1 365 ? 19.811  65.181  -11.288 1.00 57.65  ? 365 TYR C C   1 
ATOM   10648 O O   . TYR C 1 365 ? 18.603  65.218  -11.028 1.00 59.80  ? 365 TYR C O   1 
ATOM   10649 C CB  . TYR C 1 365 ? 20.508  63.510  -13.134 1.00 62.12  ? 365 TYR C CB  1 
ATOM   10650 C CG  . TYR C 1 365 ? 20.654  63.350  -14.643 1.00 66.69  ? 365 TYR C CG  1 
ATOM   10651 C CD1 . TYR C 1 365 ? 19.551  63.474  -15.477 1.00 59.73  ? 365 TYR C CD1 1 
ATOM   10652 C CD2 . TYR C 1 365 ? 21.886  63.086  -15.228 1.00 61.09  ? 365 TYR C CD2 1 
ATOM   10653 C CE1 . TYR C 1 365 ? 19.671  63.324  -16.846 1.00 65.86  ? 365 TYR C CE1 1 
ATOM   10654 C CE2 . TYR C 1 365 ? 22.017  62.939  -16.595 1.00 61.67  ? 365 TYR C CE2 1 
ATOM   10655 C CZ  . TYR C 1 365 ? 20.905  63.056  -17.409 1.00 66.06  ? 365 TYR C CZ  1 
ATOM   10656 O OH  . TYR C 1 365 ? 20.995  62.891  -18.765 1.00 60.91  ? 365 TYR C OH  1 
ATOM   10657 N N   . VAL C 1 366 ? 20.761  65.350  -10.360 1.00 53.30  ? 366 VAL C N   1 
ATOM   10658 C CA  . VAL C 1 366 ? 20.407  65.618  -8.976  1.00 57.53  ? 366 VAL C CA  1 
ATOM   10659 C C   . VAL C 1 366 ? 19.599  66.918  -8.922  1.00 56.89  ? 366 VAL C C   1 
ATOM   10660 O O   . VAL C 1 366 ? 18.464  66.921  -8.442  1.00 49.65  ? 366 VAL C O   1 
ATOM   10661 C CB  . VAL C 1 366 ? 21.626  65.661  -8.030  1.00 59.46  ? 366 VAL C CB  1 
ATOM   10662 C CG1 . VAL C 1 366 ? 21.231  65.954  -6.592  1.00 56.14  ? 366 VAL C CG1 1 
ATOM   10663 C CG2 . VAL C 1 366 ? 22.435  64.371  -8.064  1.00 57.39  ? 366 VAL C CG2 1 
ATOM   10664 N N   . ASP C 1 367 ? 20.184  68.016  -9.419  1.00 55.21  ? 367 ASP C N   1 
ATOM   10665 C CA  . ASP C 1 367 ? 19.616  69.348  -9.235  1.00 54.84  ? 367 ASP C CA  1 
ATOM   10666 C C   . ASP C 1 367 ? 18.323  69.528  -10.027 1.00 53.27  ? 367 ASP C C   1 
ATOM   10667 O O   . ASP C 1 367 ? 17.421  70.221  -9.569  1.00 56.55  ? 367 ASP C O   1 
ATOM   10668 C CB  . ASP C 1 367 ? 20.572  70.444  -9.669  1.00 59.06  ? 367 ASP C CB  1 
ATOM   10669 C CG  . ASP C 1 367 ? 21.851  70.581  -8.856  1.00 64.09  ? 367 ASP C CG  1 
ATOM   10670 O OD1 . ASP C 1 367 ? 21.900  70.051  -7.721  1.00 62.29  ? 367 ASP C OD1 1 
ATOM   10671 O OD2 . ASP C 1 367 ? 22.796  71.199  -9.388  1.00 73.10  ? 367 ASP C OD2 1 
ATOM   10672 N N   . LEU C 1 368 ? 18.239  68.938  -11.225 1.00 51.11  ? 368 LEU C N   1 
ATOM   10673 C CA  . LEU C 1 368 ? 17.027  69.071  -12.015 1.00 58.29  ? 368 LEU C CA  1 
ATOM   10674 C C   . LEU C 1 368 ? 15.934  68.188  -11.424 1.00 49.69  ? 368 LEU C C   1 
ATOM   10675 O O   . LEU C 1 368 ? 14.759  68.449  -11.659 1.00 55.03  ? 368 LEU C O   1 
ATOM   10676 C CB  . LEU C 1 368 ? 17.250  68.780  -13.501 1.00 60.66  ? 368 LEU C CB  1 
ATOM   10677 C CG  . LEU C 1 368 ? 18.267  69.677  -14.220 1.00 67.29  ? 368 LEU C CG  1 
ATOM   10678 C CD1 . LEU C 1 368 ? 18.387  69.249  -15.677 1.00 68.95  ? 368 LEU C CD1 1 
ATOM   10679 C CD2 . LEU C 1 368 ? 17.947  71.166  -14.129 1.00 70.21  ? 368 LEU C CD2 1 
ATOM   10680 N N   . GLY C 1 369 ? 16.326  67.131  -10.703 1.00 49.04  ? 369 GLY C N   1 
ATOM   10681 C CA  . GLY C 1 369 ? 15.384  66.314  -9.943  1.00 52.19  ? 369 GLY C CA  1 
ATOM   10682 C C   . GLY C 1 369 ? 14.767  67.104  -8.789  1.00 53.99  ? 369 GLY C C   1 
ATOM   10683 O O   . GLY C 1 369 ? 13.548  67.143  -8.612  1.00 49.90  ? 369 GLY C O   1 
ATOM   10684 N N   . ARG C 1 370 ? 15.631  67.795  -8.045  1.00 51.18  ? 370 ARG C N   1 
ATOM   10685 C CA  . ARG C 1 370 ? 15.195  68.673  -6.973  1.00 52.96  ? 370 ARG C CA  1 
ATOM   10686 C C   . ARG C 1 370 ? 14.202  69.695  -7.510  1.00 43.80  ? 370 ARG C C   1 
ATOM   10687 O O   . ARG C 1 370 ? 13.146  69.876  -6.940  1.00 44.73  ? 370 ARG C O   1 
ATOM   10688 C CB  . ARG C 1 370 ? 16.419  69.340  -6.331  1.00 57.88  ? 370 ARG C CB  1 
ATOM   10689 C CG  . ARG C 1 370 ? 17.244  68.377  -5.481  1.00 66.31  ? 370 ARG C CG  1 
ATOM   10690 C CD  . ARG C 1 370 ? 18.560  68.997  -5.024  1.00 64.16  ? 370 ARG C CD  1 
ATOM   10691 N NE  . ARG C 1 370 ? 18.190  70.233  -4.331  1.00 67.09  ? 370 ARG C NE  1 
ATOM   10692 C CZ  . ARG C 1 370 ? 18.467  71.472  -4.743  1.00 73.34  ? 370 ARG C CZ  1 
ATOM   10693 N NH1 . ARG C 1 370 ? 19.405  71.701  -5.676  1.00 61.87  ? 370 ARG C NH1 1 
ATOM   10694 N NH2 . ARG C 1 370 ? 17.824  72.473  -4.155  1.00 62.07  ? 370 ARG C NH2 1 
ATOM   10695 N N   . ALA C 1 371 ? 14.586  70.369  -8.592  1.00 45.33  ? 371 ALA C N   1 
ATOM   10696 C CA  . ALA C 1 371 ? 13.789  71.362  -9.284  1.00 46.40  ? 371 ALA C CA  1 
ATOM   10697 C C   . ALA C 1 371 ? 12.395  70.840  -9.623  1.00 51.36  ? 371 ALA C C   1 
ATOM   10698 O O   . ALA C 1 371 ? 11.411  71.565  -9.485  1.00 53.47  ? 371 ALA C O   1 
ATOM   10699 C CB  . ALA C 1 371 ? 14.519  71.751  -10.556 1.00 50.98  ? 371 ALA C CB  1 
ATOM   10700 N N   . HIS C 1 372 ? 12.334  69.602  -10.136 1.00 56.24  ? 372 HIS C N   1 
ATOM   10701 C CA  . HIS C 1 372 ? 11.068  68.973  -10.487 1.00 50.59  ? 372 HIS C CA  1 
ATOM   10702 C C   . HIS C 1 372 ? 10.218  68.834  -9.237  1.00 44.45  ? 372 HIS C C   1 
ATOM   10703 O O   . HIS C 1 372 ? 9.014   69.067  -9.291  1.00 39.53  ? 372 HIS C O   1 
ATOM   10704 C CB  . HIS C 1 372 ? 11.248  67.575  -11.092 1.00 49.24  ? 372 HIS C CB  1 
ATOM   10705 C CG  . HIS C 1 372 ? 9.931   67.013  -11.514 1.00 52.21  ? 372 HIS C CG  1 
ATOM   10706 N ND1 . HIS C 1 372 ? 9.132   66.226  -10.705 1.00 50.17  ? 372 HIS C ND1 1 
ATOM   10707 C CD2 . HIS C 1 372 ? 9.247   67.200  -12.659 1.00 50.93  ? 372 HIS C CD2 1 
ATOM   10708 C CE1 . HIS C 1 372 ? 8.005   65.945  -11.352 1.00 50.91  ? 372 HIS C CE1 1 
ATOM   10709 N NE2 . HIS C 1 372 ? 8.062   66.507  -12.542 1.00 52.55  ? 372 HIS C NE2 1 
ATOM   10710 N N   . TYR C 1 373 ? 10.881  68.427  -8.143  1.00 45.65  ? 373 TYR C N   1 
ATOM   10711 C CA  . TYR C 1 373 ? 10.249  68.278  -6.843  1.00 51.53  ? 373 TYR C CA  1 
ATOM   10712 C C   . TYR C 1 373 ? 9.766   69.648  -6.374  1.00 44.34  ? 373 TYR C C   1 
ATOM   10713 O O   . TYR C 1 373 ? 8.591   69.787  -6.050  1.00 43.55  ? 373 TYR C O   1 
ATOM   10714 C CB  . TYR C 1 373 ? 11.162  67.622  -5.789  1.00 53.55  ? 373 TYR C CB  1 
ATOM   10715 C CG  . TYR C 1 373 ? 10.567  67.477  -4.387  1.00 50.16  ? 373 TYR C CG  1 
ATOM   10716 C CD1 . TYR C 1 373 ? 10.682  68.490  -3.443  1.00 54.57  ? 373 TYR C CD1 1 
ATOM   10717 C CD2 . TYR C 1 373 ? 9.856   66.344  -4.014  1.00 54.21  ? 373 TYR C CD2 1 
ATOM   10718 C CE1 . TYR C 1 373 ? 10.129  68.382  -2.176  1.00 51.84  ? 373 TYR C CE1 1 
ATOM   10719 C CE2 . TYR C 1 373 ? 9.329   66.203  -2.738  1.00 55.84  ? 373 TYR C CE2 1 
ATOM   10720 C CZ  . TYR C 1 373 ? 9.466   67.227  -1.815  1.00 52.00  ? 373 TYR C CZ  1 
ATOM   10721 O OH  . TYR C 1 373 ? 8.926   67.114  -0.571  1.00 50.22  ? 373 TYR C OH  1 
ATOM   10722 N N   . LEU C 1 374 ? 10.676  70.634  -6.347  1.00 45.08  ? 374 LEU C N   1 
ATOM   10723 C CA  . LEU C 1 374 ? 10.405  71.967  -5.802  1.00 51.05  ? 374 LEU C CA  1 
ATOM   10724 C C   . LEU C 1 374 ? 9.259   72.679  -6.537  1.00 50.40  ? 374 LEU C C   1 
ATOM   10725 O O   . LEU C 1 374 ? 8.528   73.451  -5.922  1.00 56.41  ? 374 LEU C O   1 
ATOM   10726 C CB  . LEU C 1 374 ? 11.684  72.808  -5.840  1.00 50.61  ? 374 LEU C CB  1 
ATOM   10727 C CG  . LEU C 1 374 ? 12.815  72.354  -4.912  1.00 51.72  ? 374 LEU C CG  1 
ATOM   10728 C CD1 . LEU C 1 374 ? 14.140  72.977  -5.304  1.00 52.83  ? 374 LEU C CD1 1 
ATOM   10729 C CD2 . LEU C 1 374 ? 12.480  72.659  -3.473  1.00 52.31  ? 374 LEU C CD2 1 
ATOM   10730 N N   . GLU C 1 375 ? 9.109   72.415  -7.843  1.00 53.10  ? 375 GLU C N   1 
ATOM   10731 C CA  . GLU C 1 375 ? 8.136   73.089  -8.693  1.00 57.05  ? 375 GLU C CA  1 
ATOM   10732 C C   . GLU C 1 375 ? 6.732   72.563  -8.402  1.00 54.64  ? 375 GLU C C   1 
ATOM   10733 O O   . GLU C 1 375 ? 5.797   73.356  -8.341  1.00 49.86  ? 375 GLU C O   1 
ATOM   10734 C CB  . GLU C 1 375 ? 8.504   72.910  -10.172 1.00 57.35  ? 375 GLU C CB  1 
ATOM   10735 C CG  . GLU C 1 375 ? 7.457   73.408  -11.171 1.00 60.18  ? 375 GLU C CG  1 
ATOM   10736 C CD  . GLU C 1 375 ? 7.795   73.171  -12.649 1.00 65.50  ? 375 GLU C CD  1 
ATOM   10737 O OE1 . GLU C 1 375 ? 8.014   72.008  -13.120 1.00 54.96  ? 375 GLU C OE1 1 
ATOM   10738 O OE2 . GLU C 1 375 ? 7.830   74.204  -13.350 1.00 65.78  ? 375 GLU C OE2 1 
ATOM   10739 N N   . ASN C 1 376 ? 6.610   71.240  -8.199  1.00 49.27  ? 376 ASN C N   1 
ATOM   10740 C CA  . ASN C 1 376 ? 5.326   70.558  -8.232  1.00 51.94  ? 376 ASN C CA  1 
ATOM   10741 C C   . ASN C 1 376 ? 4.867   70.060  -6.855  1.00 47.35  ? 376 ASN C C   1 
ATOM   10742 O O   . ASN C 1 376 ? 3.692   69.704  -6.741  1.00 47.88  ? 376 ASN C O   1 
ATOM   10743 C CB  . ASN C 1 376 ? 5.355   69.401  -9.228  1.00 54.18  ? 376 ASN C CB  1 
ATOM   10744 C CG  . ASN C 1 376 ? 5.615   69.873  -10.642 1.00 55.92  ? 376 ASN C CG  1 
ATOM   10745 O OD1 . ASN C 1 376 ? 4.727   70.462  -11.262 1.00 54.03  ? 376 ASN C OD1 1 
ATOM   10746 N ND2 . ASN C 1 376 ? 6.807   69.628  -11.169 1.00 54.30  ? 376 ASN C ND2 1 
ATOM   10747 N N   . ILE C 1 377 ? 5.752   70.024  -5.834  1.00 38.20  ? 377 ILE C N   1 
ATOM   10748 C CA  . ILE C 1 377 ? 5.424   69.439  -4.530  1.00 47.44  ? 377 ILE C CA  1 
ATOM   10749 C C   . ILE C 1 377 ? 4.136   70.021  -3.933  1.00 47.28  ? 377 ILE C C   1 
ATOM   10750 O O   . ILE C 1 377 ? 3.326   69.264  -3.409  1.00 53.11  ? 377 ILE C O   1 
ATOM   10751 C CB  . ILE C 1 377 ? 6.583   69.527  -3.498  1.00 52.14  ? 377 ILE C CB  1 
ATOM   10752 C CG1 . ILE C 1 377 ? 6.215   68.841  -2.154  1.00 52.62  ? 377 ILE C CG1 1 
ATOM   10753 C CG2 . ILE C 1 377 ? 7.059   70.963  -3.248  1.00 49.59  ? 377 ILE C CG2 1 
ATOM   10754 C CD1 . ILE C 1 377 ? 5.916   67.351  -2.249  1.00 49.65  ? 377 ILE C CD1 1 
ATOM   10755 N N   . HIS C 1 378 ? 3.982   71.356  -3.957  1.00 48.24  ? 378 HIS C N   1 
ATOM   10756 C CA  . HIS C 1 378 ? 2.831   72.028  -3.375  1.00 45.63  ? 378 HIS C CA  1 
ATOM   10757 C C   . HIS C 1 378 ? 1.563   71.623  -4.132  1.00 46.79  ? 378 HIS C C   1 
ATOM   10758 O O   . HIS C 1 378 ? 0.477   71.623  -3.556  1.00 51.79  ? 378 HIS C O   1 
ATOM   10759 C CB  . HIS C 1 378 ? 3.051   73.554  -3.314  1.00 47.37  ? 378 HIS C CB  1 
ATOM   10760 C CG  . HIS C 1 378 ? 2.814   74.268  -4.611  1.00 50.90  ? 378 HIS C CG  1 
ATOM   10761 N ND1 . HIS C 1 378 ? 3.754   74.380  -5.621  1.00 55.73  ? 378 HIS C ND1 1 
ATOM   10762 C CD2 . HIS C 1 378 ? 1.693   74.844  -5.086  1.00 52.60  ? 378 HIS C CD2 1 
ATOM   10763 C CE1 . HIS C 1 378 ? 3.219   75.032  -6.651  1.00 54.70  ? 378 HIS C CE1 1 
ATOM   10764 N NE2 . HIS C 1 378 ? 1.965   75.331  -6.350  1.00 53.24  ? 378 HIS C NE2 1 
ATOM   10765 N N   . ASN C 1 379 ? 1.702   71.295  -5.425  1.00 48.10  ? 379 ASN C N   1 
ATOM   10766 C CA  . ASN C 1 379 ? 0.593   70.777  -6.226  1.00 50.41  ? 379 ASN C CA  1 
ATOM   10767 C C   . ASN C 1 379 ? 0.232   69.362  -5.769  1.00 47.93  ? 379 ASN C C   1 
ATOM   10768 O O   . ASN C 1 379 ? -0.955  69.021  -5.681  1.00 43.87  ? 379 ASN C O   1 
ATOM   10769 C CB  . ASN C 1 379 ? 0.873   70.839  -7.730  1.00 47.81  ? 379 ASN C CB  1 
ATOM   10770 C CG  . ASN C 1 379 ? 0.753   72.243  -8.297  1.00 55.58  ? 379 ASN C CG  1 
ATOM   10771 O OD1 . ASN C 1 379 ? -0.011  73.077  -7.793  1.00 54.50  ? 379 ASN C OD1 1 
ATOM   10772 N ND2 . ASN C 1 379 ? 1.493   72.536  -9.357  1.00 58.58  ? 379 ASN C ND2 1 
ATOM   10773 N N   . ALA C 1 380 ? 1.257   68.554  -5.462  1.00 45.75  ? 380 ALA C N   1 
ATOM   10774 C CA  . ALA C 1 380 ? 1.034   67.171  -5.049  1.00 50.23  ? 380 ALA C CA  1 
ATOM   10775 C C   . ALA C 1 380 ? 0.368   67.121  -3.669  1.00 49.75  ? 380 ALA C C   1 
ATOM   10776 O O   . ALA C 1 380 ? -0.551  66.323  -3.448  1.00 45.72  ? 380 ALA C O   1 
ATOM   10777 C CB  . ALA C 1 380 ? 2.336   66.404  -5.082  1.00 48.14  ? 380 ALA C CB  1 
ATOM   10778 N N   . VAL C 1 381 ? 0.823   67.993  -2.754  1.00 44.23  ? 381 VAL C N   1 
ATOM   10779 C CA  . VAL C 1 381 ? 0.241   68.078  -1.421  1.00 49.95  ? 381 VAL C CA  1 
ATOM   10780 C C   . VAL C 1 381 ? -1.203  68.582  -1.508  1.00 46.80  ? 381 VAL C C   1 
ATOM   10781 O O   . VAL C 1 381 ? -2.112  68.002  -0.912  1.00 41.49  ? 381 VAL C O   1 
ATOM   10782 C CB  . VAL C 1 381 ? 1.107   68.949  -0.487  1.00 52.59  ? 381 VAL C CB  1 
ATOM   10783 C CG1 . VAL C 1 381 ? 0.372   69.362  0.794   1.00 48.38  ? 381 VAL C CG1 1 
ATOM   10784 C CG2 . VAL C 1 381 ? 2.429   68.243  -0.170  1.00 53.42  ? 381 VAL C CG2 1 
ATOM   10785 N N   . ASN C 1 382 ? -1.409  69.656  -2.274  1.00 49.16  ? 382 ASN C N   1 
ATOM   10786 C CA  . ASN C 1 382 ? -2.725  70.261  -2.427  1.00 49.61  ? 382 ASN C CA  1 
ATOM   10787 C C   . ASN C 1 382 ? -3.720  69.229  -2.954  1.00 46.63  ? 382 ASN C C   1 
ATOM   10788 O O   . ASN C 1 382 ? -4.867  69.210  -2.511  1.00 42.51  ? 382 ASN C O   1 
ATOM   10789 C CB  . ASN C 1 382 ? -2.666  71.504  -3.315  1.00 50.47  ? 382 ASN C CB  1 
ATOM   10790 C CG  . ASN C 1 382 ? -4.046  72.027  -3.627  1.00 48.46  ? 382 ASN C CG  1 
ATOM   10791 O OD1 . ASN C 1 382 ? -4.744  72.481  -2.723  1.00 48.14  ? 382 ASN C OD1 1 
ATOM   10792 N ND2 . ASN C 1 382 ? -4.485  71.928  -4.874  1.00 52.08  ? 382 ASN C ND2 1 
ATOM   10793 N N   . GLN C 1 383 ? -3.268  68.412  -3.925  1.00 50.01  ? 383 GLN C N   1 
ATOM   10794 C CA  . GLN C 1 383 ? -4.047  67.305  -4.466  1.00 49.00  ? 383 GLN C CA  1 
ATOM   10795 C C   . GLN C 1 383 ? -4.403  66.277  -3.382  1.00 47.31  ? 383 GLN C C   1 
ATOM   10796 O O   . GLN C 1 383 ? -5.541  65.833  -3.307  1.00 47.55  ? 383 GLN C O   1 
ATOM   10797 C CB  . GLN C 1 383 ? -3.314  66.605  -5.611  1.00 51.37  ? 383 GLN C CB  1 
ATOM   10798 C CG  . GLN C 1 383 ? -4.134  65.510  -6.286  1.00 53.85  ? 383 GLN C CG  1 
ATOM   10799 C CD  . GLN C 1 383 ? -5.384  66.047  -6.956  1.00 57.46  ? 383 GLN C CD  1 
ATOM   10800 O OE1 . GLN C 1 383 ? -5.307  66.659  -8.030  1.00 55.46  ? 383 GLN C OE1 1 
ATOM   10801 N NE2 . GLN C 1 383 ? -6.536  65.856  -6.314  1.00 52.72  ? 383 GLN C NE2 1 
ATOM   10802 N N   . LEU C 1 384 ? -3.450  65.885  -2.537  1.00 46.37  ? 384 LEU C N   1 
ATOM   10803 C CA  . LEU C 1 384 ? -3.732  64.923  -1.473  1.00 49.24  ? 384 LEU C CA  1 
ATOM   10804 C C   . LEU C 1 384 ? -4.825  65.478  -0.548  1.00 53.46  ? 384 LEU C C   1 
ATOM   10805 O O   . LEU C 1 384 ? -5.728  64.752  -0.104  1.00 46.73  ? 384 LEU C O   1 
ATOM   10806 C CB  . LEU C 1 384 ? -2.431  64.630  -0.718  1.00 47.30  ? 384 LEU C CB  1 
ATOM   10807 C CG  . LEU C 1 384 ? -2.531  63.696  0.493   1.00 48.65  ? 384 LEU C CG  1 
ATOM   10808 C CD1 . LEU C 1 384 ? -2.947  62.298  0.025   1.00 52.51  ? 384 LEU C CD1 1 
ATOM   10809 C CD2 . LEU C 1 384 ? -1.223  63.634  1.270   1.00 45.06  ? 384 LEU C CD2 1 
ATOM   10810 N N   . ILE C 1 385 ? -4.749  66.793  -0.275  1.00 55.27  ? 385 ILE C N   1 
ATOM   10811 C CA  . ILE C 1 385 ? -5.728  67.459  0.575   1.00 53.91  ? 385 ILE C CA  1 
ATOM   10812 C C   . ILE C 1 385 ? -7.089  67.507  -0.132  1.00 46.25  ? 385 ILE C C   1 
ATOM   10813 O O   . ILE C 1 385 ? -8.097  67.208  0.491   1.00 52.72  ? 385 ILE C O   1 
ATOM   10814 C CB  . ILE C 1 385 ? -5.208  68.834  1.042   1.00 57.12  ? 385 ILE C CB  1 
ATOM   10815 C CG1 . ILE C 1 385 ? -4.061  68.654  2.046   1.00 55.54  ? 385 ILE C CG1 1 
ATOM   10816 C CG2 . ILE C 1 385 ? -6.328  69.691  1.632   1.00 53.61  ? 385 ILE C CG2 1 
ATOM   10817 C CD1 . ILE C 1 385 ? -3.042  69.772  2.031   1.00 59.48  ? 385 ILE C CD1 1 
ATOM   10818 N N   . GLU C 1 386 ? -7.132  67.779  -1.439  1.00 47.39  ? 386 GLU C N   1 
ATOM   10819 C CA  . GLU C 1 386 ? -8.405  67.764  -2.157  1.00 57.49  ? 386 GLU C CA  1 
ATOM   10820 C C   . GLU C 1 386 ? -9.119  66.430  -1.922  1.00 57.72  ? 386 GLU C C   1 
ATOM   10821 O O   . GLU C 1 386 ? -10.335 66.411  -1.736  1.00 56.84  ? 386 GLU C O   1 
ATOM   10822 C CB  . GLU C 1 386 ? -8.302  68.018  -3.665  1.00 60.19  ? 386 GLU C CB  1 
ATOM   10823 C CG  . GLU C 1 386 ? -7.865  69.432  -4.040  1.00 71.68  ? 386 GLU C CG  1 
ATOM   10824 C CD  . GLU C 1 386 ? -8.956  70.454  -4.300  1.00 77.46  ? 386 GLU C CD  1 
ATOM   10825 O OE1 . GLU C 1 386 ? -10.162 70.175  -4.153  1.00 87.05  ? 386 GLU C OE1 1 
ATOM   10826 O OE2 . GLU C 1 386 ? -8.564  71.566  -4.687  1.00 94.92  ? 386 GLU C OE2 1 
ATOM   10827 N N   . PHE C 1 387 ? -8.358  65.323  -1.897  1.00 58.16  ? 387 PHE C N   1 
ATOM   10828 C CA  . PHE C 1 387 ? -8.933  63.989  -1.756  1.00 52.24  ? 387 PHE C CA  1 
ATOM   10829 C C   . PHE C 1 387 ? -9.685  63.843  -0.429  1.00 48.97  ? 387 PHE C C   1 
ATOM   10830 O O   . PHE C 1 387 ? -10.616 63.051  -0.341  1.00 51.83  ? 387 PHE C O   1 
ATOM   10831 C CB  . PHE C 1 387 ? -7.846  62.913  -1.898  1.00 48.88  ? 387 PHE C CB  1 
ATOM   10832 C CG  . PHE C 1 387 ? -7.273  62.684  -3.297  1.00 45.23  ? 387 PHE C CG  1 
ATOM   10833 C CD1 . PHE C 1 387 ? -8.059  62.825  -4.443  1.00 44.51  ? 387 PHE C CD1 1 
ATOM   10834 C CD2 . PHE C 1 387 ? -5.935  62.348  -3.465  1.00 42.12  ? 387 PHE C CD2 1 
ATOM   10835 C CE1 . PHE C 1 387 ? -7.523  62.614  -5.704  1.00 46.10  ? 387 PHE C CE1 1 
ATOM   10836 C CE2 . PHE C 1 387 ? -5.408  62.134  -4.730  1.00 45.22  ? 387 PHE C CE2 1 
ATOM   10837 C CZ  . PHE C 1 387 ? -6.201  62.262  -5.845  1.00 45.03  ? 387 PHE C CZ  1 
ATOM   10838 N N   . CYS C 1 388 ? -9.287  64.596  0.603   1.00 51.77  ? 388 CYS C N   1 
ATOM   10839 C CA  . CYS C 1 388 ? -9.836  64.389  1.934   1.00 58.03  ? 388 CYS C CA  1 
ATOM   10840 C C   . CYS C 1 388 ? -11.258 64.927  2.054   1.00 63.58  ? 388 CYS C C   1 
ATOM   10841 O O   . CYS C 1 388 ? -12.054 64.356  2.794   1.00 63.98  ? 388 CYS C O   1 
ATOM   10842 C CB  . CYS C 1 388 ? -9.005  65.048  3.025   1.00 55.02  ? 388 CYS C CB  1 
ATOM   10843 S SG  . CYS C 1 388 ? -7.296  64.452  3.106   1.00 56.88  ? 388 CYS C SG  1 
ATOM   10844 N N   . GLY C 1 389 ? -11.555 66.045  1.368   1.00 71.51  ? 389 GLY C N   1 
ATOM   10845 C CA  . GLY C 1 389 ? -12.796 66.778  1.600   1.00 63.19  ? 389 GLY C CA  1 
ATOM   10846 C C   . GLY C 1 389 ? -12.805 67.415  2.992   1.00 64.95  ? 389 GLY C C   1 
ATOM   10847 O O   . GLY C 1 389 ? -11.749 67.678  3.575   1.00 56.49  ? 389 GLY C O   1 
ATOM   10848 N N   . ARG C 1 390 ? -14.016 67.582  3.542   1.00 74.90  ? 390 ARG C N   1 
ATOM   10849 C CA  . ARG C 1 390 ? -14.263 68.158  4.862   1.00 78.94  ? 390 ARG C CA  1 
ATOM   10850 C C   . ARG C 1 390 ? -13.487 67.428  5.964   1.00 77.74  ? 390 ARG C C   1 
ATOM   10851 O O   . ARG C 1 390 ? -13.157 68.017  6.992   1.00 72.36  ? 390 ARG C O   1 
ATOM   10852 C CB  . ARG C 1 390 ? -15.762 68.062  5.189   1.00 95.39  ? 390 ARG C CB  1 
ATOM   10853 C CG  . ARG C 1 390 ? -16.695 68.614  4.113   1.00 110.40 ? 390 ARG C CG  1 
ATOM   10854 C CD  . ARG C 1 390 ? -18.181 68.220  4.199   1.00 104.20 ? 390 ARG C CD  1 
ATOM   10855 N NE  . ARG C 1 390 ? -18.919 68.575  2.975   1.00 99.83  ? 390 ARG C NE  1 
ATOM   10856 C CZ  . ARG C 1 390 ? -19.003 69.785  2.402   1.00 101.79 ? 390 ARG C CZ  1 
ATOM   10857 N NH1 . ARG C 1 390 ? -18.453 70.846  2.966   1.00 110.39 ? 390 ARG C NH1 1 
ATOM   10858 N NH2 . ARG C 1 390 ? -19.643 69.945  1.254   1.00 96.75  ? 390 ARG C NH2 1 
ATOM   10859 N N   . GLY C 1 391 ? -13.192 66.140  5.746   1.00 79.98  ? 391 GLY C N   1 
ATOM   10860 C CA  . GLY C 1 391 ? -12.579 65.288  6.752   1.00 79.17  ? 391 GLY C CA  1 
ATOM   10861 C C   . GLY C 1 391 ? -11.456 65.956  7.546   1.00 79.94  ? 391 GLY C C   1 
ATOM   10862 O O   . GLY C 1 391 ? -11.228 65.577  8.692   1.00 79.34  ? 391 GLY C O   1 
ATOM   10863 N N   . VAL C 1 392 ? -10.731 66.910  6.944   1.00 83.14  ? 392 VAL C N   1 
ATOM   10864 C CA  . VAL C 1 392 ? -9.570  67.509  7.598   1.00 89.77  ? 392 VAL C CA  1 
ATOM   10865 C C   . VAL C 1 392 ? -9.987  68.653  8.531   1.00 97.03  ? 392 VAL C C   1 
ATOM   10866 O O   . VAL C 1 392 ? -9.184  69.076  9.358   1.00 99.63  ? 392 VAL C O   1 
ATOM   10867 C CB  . VAL C 1 392 ? -8.479  67.971  6.607   1.00 86.59  ? 392 VAL C CB  1 
ATOM   10868 C CG1 . VAL C 1 392 ? -7.778  66.793  5.949   1.00 78.95  ? 392 VAL C CG1 1 
ATOM   10869 C CG2 . VAL C 1 392 ? -9.000  68.949  5.557   1.00 86.77  ? 392 VAL C CG2 1 
ATOM   10870 N N   . VAL C 1 393 ? -11.225 69.158  8.401   1.00 112.02 ? 393 VAL C N   1 
ATOM   10871 C CA  . VAL C 1 393 ? -11.766 70.174  9.304   1.00 113.74 ? 393 VAL C CA  1 
ATOM   10872 C C   . VAL C 1 393 ? -12.545 69.486  10.429  1.00 107.48 ? 393 VAL C C   1 
ATOM   10873 O O   . VAL C 1 393 ? -12.496 69.908  11.581  1.00 106.09 ? 393 VAL C O   1 
ATOM   10874 C CB  . VAL C 1 393 ? -12.690 71.180  8.583   1.00 111.62 ? 393 VAL C CB  1 
ATOM   10875 C CG1 . VAL C 1 393 ? -12.832 72.472  9.377   1.00 114.31 ? 393 VAL C CG1 1 
ATOM   10876 C CG2 . VAL C 1 393 ? -12.241 71.484  7.158   1.00 116.55 ? 393 VAL C CG2 1 
ATOM   10877 N N   . MET C 1 394 ? -13.234 68.404  10.052  1.00 102.17 ? 394 MET C N   1 
ATOM   10878 C CA  . MET C 1 394 ? -14.290 67.753  10.807  1.00 101.59 ? 394 MET C CA  1 
ATOM   10879 C C   . MET C 1 394 ? -13.720 66.939  11.971  1.00 101.09 ? 394 MET C C   1 
ATOM   10880 O O   . MET C 1 394 ? -14.361 66.830  13.020  1.00 108.34 ? 394 MET C O   1 
ATOM   10881 C CB  . MET C 1 394 ? -14.996 66.796  9.836   1.00 110.68 ? 394 MET C CB  1 
ATOM   10882 C CG  . MET C 1 394 ? -16.429 66.403  10.157  1.00 117.95 ? 394 MET C CG  1 
ATOM   10883 S SD  . MET C 1 394 ? -17.102 65.494  8.747   1.00 110.60 ? 394 MET C SD  1 
ATOM   10884 C CE  . MET C 1 394 ? -18.884 65.560  8.903   1.00 97.91  ? 394 MET C CE  1 
ATOM   10885 N N   . SER C 1 395 ? -12.480 66.456  11.779  1.00 81.97  ? 395 SER C N   1 
ATOM   10886 C CA  . SER C 1 395 ? -11.967 65.191  12.294  1.00 68.91  ? 395 SER C CA  1 
ATOM   10887 C C   . SER C 1 395 ? -11.870 65.110  13.822  1.00 60.34  ? 395 SER C C   1 
ATOM   10888 O O   . SER C 1 395 ? -10.993 65.724  14.432  1.00 54.65  ? 395 SER C O   1 
ATOM   10889 C CB  . SER C 1 395 ? -10.620 64.890  11.677  1.00 73.10  ? 395 SER C CB  1 
ATOM   10890 O OG  . SER C 1 395 ? -10.778 64.021  10.566  1.00 81.19  ? 395 SER C OG  1 
ATOM   10891 N N   . PRO C 1 396 ? -12.657 64.220  14.477  1.00 56.15  ? 396 PRO C N   1 
ATOM   10892 C CA  . PRO C 1 396 ? -12.701 64.147  15.943  1.00 58.58  ? 396 PRO C CA  1 
ATOM   10893 C C   . PRO C 1 396 ? -11.398 63.738  16.618  1.00 55.81  ? 396 PRO C C   1 
ATOM   10894 O O   . PRO C 1 396 ? -10.544 63.068  16.023  1.00 47.03  ? 396 PRO C O   1 
ATOM   10895 C CB  . PRO C 1 396 ? -13.800 63.134  16.251  1.00 58.07  ? 396 PRO C CB  1 
ATOM   10896 C CG  . PRO C 1 396 ? -14.551 62.991  14.950  1.00 61.37  ? 396 PRO C CG  1 
ATOM   10897 C CD  . PRO C 1 396 ? -13.541 63.231  13.847  1.00 55.45  ? 396 PRO C CD  1 
ATOM   10898 N N   . THR C 1 397 ? -11.256 64.184  17.869  1.00 51.65  ? 397 THR C N   1 
ATOM   10899 C CA  . THR C 1 397 ? -10.097 63.830  18.680  1.00 54.45  ? 397 THR C CA  1 
ATOM   10900 C C   . THR C 1 397 ? -10.342 62.436  19.250  1.00 55.88  ? 397 THR C C   1 
ATOM   10901 O O   . THR C 1 397 ? -11.437 61.886  19.115  1.00 56.07  ? 397 THR C O   1 
ATOM   10902 C CB  . THR C 1 397 ? -9.860  64.872  19.780  1.00 49.97  ? 397 THR C CB  1 
ATOM   10903 O OG1 . THR C 1 397 ? -11.014 64.915  20.628  1.00 45.75  ? 397 THR C OG1 1 
ATOM   10904 C CG2 . THR C 1 397 ? -9.633  66.261  19.210  1.00 48.35  ? 397 THR C CG2 1 
ATOM   10905 N N   . LYS C 1 398 ? -9.310  61.878  19.887  1.00 54.57  ? 398 LYS C N   1 
ATOM   10906 C CA  . LYS C 1 398 ? -9.447  60.612  20.582  1.00 56.92  ? 398 LYS C CA  1 
ATOM   10907 C C   . LYS C 1 398 ? -10.430 60.779  21.745  1.00 52.39  ? 398 LYS C C   1 
ATOM   10908 O O   . LYS C 1 398 ? -11.258 59.907  21.973  1.00 51.91  ? 398 LYS C O   1 
ATOM   10909 C CB  . LYS C 1 398 ? -8.090  60.044  21.011  1.00 58.62  ? 398 LYS C CB  1 
ATOM   10910 C CG  . LYS C 1 398 ? -8.237  58.786  21.835  1.00 63.69  ? 398 LYS C CG  1 
ATOM   10911 C CD  . LYS C 1 398 ? -7.233  57.682  21.537  1.00 72.66  ? 398 LYS C CD  1 
ATOM   10912 C CE  . LYS C 1 398 ? -7.430  56.557  22.496  1.00 69.48  ? 398 LYS C CE  1 
ATOM   10913 N NZ  . LYS C 1 398 ? -7.247  56.995  23.888  1.00 67.79  ? 398 LYS C NZ  1 
ATOM   10914 N N   . ALA C 1 399 ? -10.364 61.913  22.446  1.00 48.51  ? 399 ALA C N   1 
ATOM   10915 C CA  . ALA C 1 399 ? -11.306 62.194  23.516  1.00 49.38  ? 399 ALA C CA  1 
ATOM   10916 C C   . ALA C 1 399 ? -12.750 62.199  22.989  1.00 55.63  ? 399 ALA C C   1 
ATOM   10917 O O   . ALA C 1 399 ? -13.656 61.701  23.667  1.00 53.69  ? 399 ALA C O   1 
ATOM   10918 C CB  . ALA C 1 399 ? -10.912 63.496  24.206  1.00 48.34  ? 399 ALA C CB  1 
ATOM   10919 N N   . ASP C 1 400 ? -12.970 62.717  21.763  1.00 54.97  ? 400 ASP C N   1 
ATOM   10920 C CA  . ASP C 1 400 ? -14.306 62.743  21.172  1.00 53.95  ? 400 ASP C CA  1 
ATOM   10921 C C   . ASP C 1 400 ? -14.823 61.323  20.933  1.00 59.50  ? 400 ASP C C   1 
ATOM   10922 O O   . ASP C 1 400 ? -16.004 61.059  21.161  1.00 66.12  ? 400 ASP C O   1 
ATOM   10923 C CB  . ASP C 1 400 ? -14.373 63.538  19.874  1.00 51.49  ? 400 ASP C CB  1 
ATOM   10924 C CG  . ASP C 1 400 ? -14.158 65.042  20.000  1.00 52.37  ? 400 ASP C CG  1 
ATOM   10925 O OD1 . ASP C 1 400 ? -14.934 65.681  20.732  1.00 51.66  ? 400 ASP C OD1 1 
ATOM   10926 O OD2 . ASP C 1 400 ? -13.207 65.562  19.376  1.00 51.61  ? 400 ASP C OD2 1 
ATOM   10927 N N   . PHE C 1 401 ? -13.944 60.427  20.450  1.00 58.22  ? 401 PHE C N   1 
ATOM   10928 C CA  . PHE C 1 401 ? -14.299 59.038  20.182  1.00 56.23  ? 401 PHE C CA  1 
ATOM   10929 C C   . PHE C 1 401 ? -14.468 58.261  21.494  1.00 54.13  ? 401 PHE C C   1 
ATOM   10930 O O   . PHE C 1 401 ? -15.299 57.372  21.552  1.00 56.32  ? 401 PHE C O   1 
ATOM   10931 C CB  . PHE C 1 401 ? -13.276 58.360  19.264  1.00 53.22  ? 401 PHE C CB  1 
ATOM   10932 C CG  . PHE C 1 401 ? -13.441 58.567  17.760  1.00 53.18  ? 401 PHE C CG  1 
ATOM   10933 C CD1 . PHE C 1 401 ? -14.660 58.343  17.124  1.00 54.05  ? 401 PHE C CD1 1 
ATOM   10934 C CD2 . PHE C 1 401 ? -12.367 58.997  16.978  1.00 57.27  ? 401 PHE C CD2 1 
ATOM   10935 C CE1 . PHE C 1 401 ? -14.796 58.527  15.751  1.00 53.96  ? 401 PHE C CE1 1 
ATOM   10936 C CE2 . PHE C 1 401 ? -12.511 59.187  15.611  1.00 61.24  ? 401 PHE C CE2 1 
ATOM   10937 C CZ  . PHE C 1 401 ? -13.724 58.949  14.999  1.00 58.29  ? 401 PHE C CZ  1 
ATOM   10938 N N   . ASP C 1 402 ? -13.734 58.628  22.556  1.00 55.87  ? 402 ASP C N   1 
ATOM   10939 C CA  . ASP C 1 402 ? -13.805 57.938  23.843  1.00 56.30  ? 402 ASP C CA  1 
ATOM   10940 C C   . ASP C 1 402 ? -14.950 58.453  24.719  1.00 54.39  ? 402 ASP C C   1 
ATOM   10941 O O   . ASP C 1 402 ? -15.170 57.924  25.800  1.00 58.76  ? 402 ASP C O   1 
ATOM   10942 C CB  . ASP C 1 402 ? -12.495 58.026  24.624  1.00 50.61  ? 402 ASP C CB  1 
ATOM   10943 C CG  . ASP C 1 402 ? -11.265 57.458  23.925  1.00 52.13  ? 402 ASP C CG  1 
ATOM   10944 O OD1 . ASP C 1 402 ? -11.439 56.902  22.813  1.00 53.54  ? 402 ASP C OD1 1 
ATOM   10945 O OD2 . ASP C 1 402 ? -10.132 57.599  24.478  1.00 54.56  ? 402 ASP C OD2 1 
ATOM   10946 N N   . HIS C 1 403 ? -15.679 59.487  24.292  1.00 61.68  ? 403 HIS C N   1 
ATOM   10947 C CA  . HIS C 1 403 ? -16.828 59.942  25.065  1.00 64.38  ? 403 HIS C CA  1 
ATOM   10948 C C   . HIS C 1 403 ? -17.817 58.784  25.245  1.00 65.76  ? 403 HIS C C   1 
ATOM   10949 O O   . HIS C 1 403 ? -18.133 58.088  24.281  1.00 61.32  ? 403 HIS C O   1 
ATOM   10950 C CB  . HIS C 1 403 ? -17.481 61.164  24.410  1.00 60.82  ? 403 HIS C CB  1 
ATOM   10951 C CG  . HIS C 1 403 ? -18.540 61.857  25.220  1.00 61.90  ? 403 HIS C CG  1 
ATOM   10952 N ND1 . HIS C 1 403 ? -19.868 61.483  25.197  1.00 56.68  ? 403 HIS C ND1 1 
ATOM   10953 C CD2 . HIS C 1 403 ? -18.470 62.924  26.033  1.00 59.62  ? 403 HIS C CD2 1 
ATOM   10954 C CE1 . HIS C 1 403 ? -20.565 62.300  25.971  1.00 59.93  ? 403 HIS C CE1 1 
ATOM   10955 N NE2 . HIS C 1 403 ? -19.739 63.177  26.491  1.00 63.72  ? 403 HIS C NE2 1 
ATOM   10956 N N   . PRO C 1 404 ? -18.338 58.546  26.475  1.00 69.59  ? 404 PRO C N   1 
ATOM   10957 C CA  . PRO C 1 404 ? -19.209 57.397  26.740  1.00 68.00  ? 404 PRO C CA  1 
ATOM   10958 C C   . PRO C 1 404 ? -20.468 57.310  25.870  1.00 66.23  ? 404 PRO C C   1 
ATOM   10959 O O   . PRO C 1 404 ? -20.819 56.220  25.436  1.00 57.14  ? 404 PRO C O   1 
ATOM   10960 C CB  . PRO C 1 404 ? -19.571 57.542  28.239  1.00 71.72  ? 404 PRO C CB  1 
ATOM   10961 C CG  . PRO C 1 404 ? -18.503 58.447  28.817  1.00 74.98  ? 404 PRO C CG  1 
ATOM   10962 C CD  . PRO C 1 404 ? -18.114 59.369  27.679  1.00 77.76  ? 404 PRO C CD  1 
ATOM   10963 N N   . PHE C 1 405 ? -21.150 58.439  25.621  1.00 59.86  ? 405 PHE C N   1 
ATOM   10964 C CA  . PHE C 1 405 ? -22.395 58.409  24.873  1.00 60.33  ? 405 PHE C CA  1 
ATOM   10965 C C   . PHE C 1 405 ? -22.143 58.761  23.399  1.00 62.34  ? 405 PHE C C   1 
ATOM   10966 O O   . PHE C 1 405 ? -22.595 58.033  22.515  1.00 55.52  ? 405 PHE C O   1 
ATOM   10967 C CB  . PHE C 1 405 ? -23.465 59.303  25.515  1.00 65.70  ? 405 PHE C CB  1 
ATOM   10968 C CG  . PHE C 1 405 ? -24.802 59.305  24.776  1.00 69.02  ? 405 PHE C CG  1 
ATOM   10969 C CD1 . PHE C 1 405 ? -25.634 58.184  24.796  1.00 75.61  ? 405 PHE C CD1 1 
ATOM   10970 C CD2 . PHE C 1 405 ? -25.223 60.425  24.053  1.00 75.15  ? 405 PHE C CD2 1 
ATOM   10971 C CE1 . PHE C 1 405 ? -26.844 58.180  24.107  1.00 75.43  ? 405 PHE C CE1 1 
ATOM   10972 C CE2 . PHE C 1 405 ? -26.437 60.424  23.371  1.00 71.43  ? 405 PHE C CE2 1 
ATOM   10973 C CZ  . PHE C 1 405 ? -27.241 59.298  23.395  1.00 77.33  ? 405 PHE C CZ  1 
ATOM   10974 N N   . LEU C 1 406 ? -21.458 59.882  23.122  1.00 61.69  ? 406 LEU C N   1 
ATOM   10975 C CA  . LEU C 1 406 ? -21.384 60.415  21.761  1.00 60.36  ? 406 LEU C CA  1 
ATOM   10976 C C   . LEU C 1 406 ? -20.310 59.678  20.959  1.00 57.41  ? 406 LEU C C   1 
ATOM   10977 O O   . LEU C 1 406 ? -20.386 59.626  19.737  1.00 55.94  ? 406 LEU C O   1 
ATOM   10978 C CB  . LEU C 1 406 ? -21.130 61.924  21.750  1.00 57.72  ? 406 LEU C CB  1 
ATOM   10979 C CG  . LEU C 1 406 ? -22.240 62.790  22.359  1.00 64.30  ? 406 LEU C CG  1 
ATOM   10980 C CD1 . LEU C 1 406 ? -21.738 64.213  22.592  1.00 64.15  ? 406 LEU C CD1 1 
ATOM   10981 C CD2 . LEU C 1 406 ? -23.521 62.776  21.510  1.00 61.28  ? 406 LEU C CD2 1 
ATOM   10982 N N   . GLY C 1 407 ? -19.312 59.130  21.657  1.00 53.81  ? 407 GLY C N   1 
ATOM   10983 C CA  . GLY C 1 407 ? -18.192 58.466  21.021  1.00 59.25  ? 407 GLY C CA  1 
ATOM   10984 C C   . GLY C 1 407 ? -18.662 57.322  20.129  1.00 62.23  ? 407 GLY C C   1 
ATOM   10985 O O   . GLY C 1 407 ? -18.355 57.307  18.933  1.00 57.62  ? 407 GLY C O   1 
ATOM   10986 N N   . PRO C 1 408 ? -19.358 56.305  20.696  1.00 66.10  ? 408 PRO C N   1 
ATOM   10987 C CA  . PRO C 1 408 ? -19.953 55.239  19.891  1.00 65.49  ? 408 PRO C CA  1 
ATOM   10988 C C   . PRO C 1 408 ? -20.745 55.754  18.689  1.00 60.14  ? 408 PRO C C   1 
ATOM   10989 O O   . PRO C 1 408 ? -20.698 55.124  17.635  1.00 59.17  ? 408 PRO C O   1 
ATOM   10990 C CB  . PRO C 1 408 ? -20.827 54.503  20.943  1.00 64.95  ? 408 PRO C CB  1 
ATOM   10991 C CG  . PRO C 1 408 ? -20.007 54.612  22.199  1.00 64.11  ? 408 PRO C CG  1 
ATOM   10992 C CD  . PRO C 1 408 ? -19.510 56.058  22.142  1.00 66.61  ? 408 PRO C CD  1 
ATOM   10993 N N   . LYS C 1 409 ? -21.431 56.902  18.857  1.00 61.84  ? 409 LYS C N   1 
ATOM   10994 C CA  . LYS C 1 409 ? -22.233 57.540  17.812  1.00 67.27  ? 409 LYS C CA  1 
ATOM   10995 C C   . LYS C 1 409 ? -21.359 58.053  16.659  1.00 64.84  ? 409 LYS C C   1 
ATOM   10996 O O   . LYS C 1 409 ? -21.780 57.997  15.499  1.00 56.65  ? 409 LYS C O   1 
ATOM   10997 C CB  . LYS C 1 409 ? -23.107 58.674  18.378  1.00 70.84  ? 409 LYS C CB  1 
ATOM   10998 C CG  . LYS C 1 409 ? -24.518 58.305  18.854  1.00 74.80  ? 409 LYS C CG  1 
ATOM   10999 C CD  . LYS C 1 409 ? -24.583 57.471  20.130  1.00 80.31  ? 409 LYS C CD  1 
ATOM   11000 C CE  . LYS C 1 409 ? -25.936 57.414  20.772  1.00 80.25  ? 409 LYS C CE  1 
ATOM   11001 N NZ  . LYS C 1 409 ? -26.964 57.010  19.814  1.00 77.84  ? 409 LYS C NZ  1 
ATOM   11002 N N   . LEU C 1 410 ? -20.167 58.583  16.990  1.00 61.02  ? 410 LEU C N   1 
ATOM   11003 C CA  . LEU C 1 410 ? -19.191 59.037  16.003  1.00 60.53  ? 410 LEU C CA  1 
ATOM   11004 C C   . LEU C 1 410 ? -18.620 57.863  15.211  1.00 56.16  ? 410 LEU C C   1 
ATOM   11005 O O   . LEU C 1 410 ? -18.406 57.995  14.006  1.00 57.28  ? 410 LEU C O   1 
ATOM   11006 C CB  . LEU C 1 410 ? -18.056 59.823  16.661  1.00 60.24  ? 410 LEU C CB  1 
ATOM   11007 C CG  . LEU C 1 410 ? -18.336 61.301  16.926  1.00 61.86  ? 410 LEU C CG  1 
ATOM   11008 C CD1 . LEU C 1 410 ? -17.353 61.878  17.927  1.00 63.07  ? 410 LEU C CD1 1 
ATOM   11009 C CD2 . LEU C 1 410 ? -18.317 62.067  15.601  1.00 60.91  ? 410 LEU C CD2 1 
ATOM   11010 N N   . GLU C 1 411 ? -18.331 56.746  15.902  1.00 58.10  ? 411 GLU C N   1 
ATOM   11011 C CA  . GLU C 1 411 ? -17.771 55.548  15.291  1.00 58.04  ? 411 GLU C CA  1 
ATOM   11012 C C   . GLU C 1 411 ? -18.757 54.956  14.281  1.00 62.02  ? 411 GLU C C   1 
ATOM   11013 O O   . GLU C 1 411 ? -18.334 54.388  13.265  1.00 55.94  ? 411 GLU C O   1 
ATOM   11014 C CB  . GLU C 1 411 ? -17.423 54.478  16.328  1.00 64.56  ? 411 GLU C CB  1 
ATOM   11015 C CG  . GLU C 1 411 ? -16.307 54.891  17.285  1.00 66.59  ? 411 GLU C CG  1 
ATOM   11016 C CD  . GLU C 1 411 ? -15.897 53.810  18.270  1.00 68.05  ? 411 GLU C CD  1 
ATOM   11017 O OE1 . GLU C 1 411 ? -16.746 53.382  19.072  1.00 75.01  ? 411 GLU C OE1 1 
ATOM   11018 O OE2 . GLU C 1 411 ? -14.730 53.391  18.243  1.00 73.41  ? 411 GLU C OE2 1 
ATOM   11019 N N   . GLU C 1 412 ? -20.057 55.084  14.603  1.00 56.10  ? 412 GLU C N   1 
ATOM   11020 C CA  . GLU C 1 412 ? -21.167 54.730  13.727  1.00 57.01  ? 412 GLU C CA  1 
ATOM   11021 C C   . GLU C 1 412 ? -21.219 55.705  12.544  1.00 60.01  ? 412 GLU C C   1 
ATOM   11022 O O   . GLU C 1 412 ? -21.202 55.285  11.386  1.00 63.15  ? 412 GLU C O   1 
ATOM   11023 C CB  . GLU C 1 412 ? -22.460 54.717  14.563  1.00 62.04  ? 412 GLU C CB  1 
ATOM   11024 C CG  . GLU C 1 412 ? -23.690 54.169  13.836  1.00 66.63  ? 412 GLU C CG  1 
ATOM   11025 C CD  . GLU C 1 412 ? -25.084 54.475  14.383  1.00 74.16  ? 412 GLU C CD  1 
ATOM   11026 O OE1 . GLU C 1 412 ? -25.284 55.044  15.488  1.00 63.45  ? 412 GLU C OE1 1 
ATOM   11027 O OE2 . GLU C 1 412 ? -26.017 54.122  13.626  1.00 78.38  ? 412 GLU C OE2 1 
ATOM   11028 N N   . ALA C 1 413 ? -21.250 57.017  12.830  1.00 58.21  ? 413 ALA C N   1 
ATOM   11029 C CA  . ALA C 1 413 ? -21.511 58.022  11.810  1.00 54.16  ? 413 ALA C CA  1 
ATOM   11030 C C   . ALA C 1 413 ? -20.337 58.235  10.846  1.00 52.89  ? 413 ALA C C   1 
ATOM   11031 O O   . ALA C 1 413 ? -20.558 58.593  9.687   1.00 54.87  ? 413 ALA C O   1 
ATOM   11032 C CB  . ALA C 1 413 ? -21.901 59.315  12.477  1.00 57.02  ? 413 ALA C CB  1 
ATOM   11033 N N   . LEU C 1 414 ? -19.091 58.066  11.307  1.00 49.38  ? 414 LEU C N   1 
ATOM   11034 C CA  . LEU C 1 414 ? -17.949 58.446  10.490  1.00 51.72  ? 414 LEU C CA  1 
ATOM   11035 C C   . LEU C 1 414 ? -17.230 57.237  9.892   1.00 54.54  ? 414 LEU C C   1 
ATOM   11036 O O   . LEU C 1 414 ? -16.191 57.430  9.258   1.00 54.69  ? 414 LEU C O   1 
ATOM   11037 C CB  . LEU C 1 414 ? -16.989 59.311  11.309  1.00 56.58  ? 414 LEU C CB  1 
ATOM   11038 C CG  . LEU C 1 414 ? -17.507 60.697  11.709  1.00 60.16  ? 414 LEU C CG  1 
ATOM   11039 C CD1 . LEU C 1 414 ? -16.425 61.510  12.427  1.00 54.59  ? 414 LEU C CD1 1 
ATOM   11040 C CD2 . LEU C 1 414 ? -18.039 61.446  10.490  1.00 59.62  ? 414 LEU C CD2 1 
ATOM   11041 N N   . ARG C 1 415 ? -17.758 56.009  10.071  1.00 59.83  ? 415 ARG C N   1 
ATOM   11042 C CA  . ARG C 1 415 ? -17.119 54.813  9.515   1.00 64.35  ? 415 ARG C CA  1 
ATOM   11043 C C   . ARG C 1 415 ? -17.338 54.699  8.002   1.00 59.88  ? 415 ARG C C   1 
ATOM   11044 O O   . ARG C 1 415 ? -18.256 55.281  7.434   1.00 57.42  ? 415 ARG C O   1 
ATOM   11045 C CB  . ARG C 1 415 ? -17.598 53.493  10.131  1.00 68.54  ? 415 ARG C CB  1 
ATOM   11046 C CG  . ARG C 1 415 ? -19.017 53.042  9.807   1.00 68.88  ? 415 ARG C CG  1 
ATOM   11047 C CD  . ARG C 1 415 ? -19.434 51.918  10.758  1.00 73.02  ? 415 ARG C CD  1 
ATOM   11048 N NE  . ARG C 1 415 ? -20.603 51.164  10.292  1.00 79.70  ? 415 ARG C NE  1 
ATOM   11049 C CZ  . ARG C 1 415 ? -21.817 51.666  10.091  1.00 75.51  ? 415 ARG C CZ  1 
ATOM   11050 N NH1 . ARG C 1 415 ? -22.099 52.919  10.376  1.00 79.73  ? 415 ARG C NH1 1 
ATOM   11051 N NH2 . ARG C 1 415 ? -22.768 50.911  9.594   1.00 73.18  ? 415 ARG C NH2 1 
ATOM   11052 N N   . GLY C 1 416 ? -16.446 53.947  7.353   1.00 62.85  ? 416 GLY C N   1 
ATOM   11053 C CA  . GLY C 1 416 ? -16.621 53.542  5.969   1.00 59.53  ? 416 GLY C CA  1 
ATOM   11054 C C   . GLY C 1 416 ? -17.100 52.096  5.888   1.00 63.87  ? 416 GLY C C   1 
ATOM   11055 O O   . GLY C 1 416 ? -17.186 51.397  6.908   1.00 58.62  ? 416 GLY C O   1 
ATOM   11056 N N   . THR C 1 417 ? -17.384 51.666  4.653   1.00 67.32  ? 417 THR C N   1 
ATOM   11057 C CA  . THR C 1 417 ? -17.800 50.305  4.364   1.00 71.43  ? 417 THR C CA  1 
ATOM   11058 C C   . THR C 1 417 ? -16.796 49.317  4.958   1.00 76.47  ? 417 THR C C   1 
ATOM   11059 O O   . THR C 1 417 ? -17.205 48.340  5.585   1.00 70.53  ? 417 THR C O   1 
ATOM   11060 C CB  . THR C 1 417 ? -17.926 50.120  2.853   1.00 72.26  ? 417 THR C CB  1 
ATOM   11061 O OG1 . THR C 1 417 ? -18.757 51.204  2.458   1.00 81.03  ? 417 THR C OG1 1 
ATOM   11062 C CG2 . THR C 1 417 ? -18.557 48.789  2.472   1.00 75.65  ? 417 THR C CG2 1 
ATOM   11063 N N   . SER C 1 418 ? -15.496 49.571  4.741   1.00 68.37  ? 418 SER C N   1 
ATOM   11064 C CA  . SER C 1 418 ? -14.474 48.561  4.969   1.00 71.57  ? 418 SER C CA  1 
ATOM   11065 C C   . SER C 1 418 ? -13.364 49.100  5.873   1.00 68.26  ? 418 SER C C   1 
ATOM   11066 O O   . SER C 1 418 ? -12.250 48.571  5.865   1.00 64.43  ? 418 SER C O   1 
ATOM   11067 C CB  . SER C 1 418 ? -13.916 48.061  3.640   1.00 71.45  ? 418 SER C CB  1 
ATOM   11068 O OG  . SER C 1 418 ? -14.935 47.501  2.816   1.00 64.45  ? 418 SER C OG  1 
ATOM   11069 N N   . ILE C 1 419 ? -13.679 50.140  6.659   1.00 54.71  ? 419 ILE C N   1 
ATOM   11070 C CA  . ILE C 1 419 ? -12.710 50.759  7.557   1.00 55.55  ? 419 ILE C CA  1 
ATOM   11071 C C   . ILE C 1 419 ? -13.499 51.451  8.663   1.00 52.46  ? 419 ILE C C   1 
ATOM   11072 O O   . ILE C 1 419 ? -14.572 51.983  8.392   1.00 56.44  ? 419 ILE C O   1 
ATOM   11073 C CB  . ILE C 1 419 ? -11.761 51.727  6.811   1.00 55.91  ? 419 ILE C CB  1 
ATOM   11074 C CG1 . ILE C 1 419 ? -10.652 52.287  7.735   1.00 55.42  ? 419 ILE C CG1 1 
ATOM   11075 C CG2 . ILE C 1 419 ? -12.542 52.851  6.116   1.00 53.59  ? 419 ILE C CG2 1 
ATOM   11076 C CD1 . ILE C 1 419 ? -9.588  53.118  7.024   1.00 53.98  ? 419 ILE C CD1 1 
ATOM   11077 N N   . SER C 1 420 ? -12.997 51.369  9.904   1.00 51.99  ? 420 SER C N   1 
ATOM   11078 C CA  . SER C 1 420 ? -13.636 51.978  11.062  1.00 50.09  ? 420 SER C CA  1 
ATOM   11079 C C   . SER C 1 420 ? -13.480 53.500  11.028  1.00 50.79  ? 420 SER C C   1 
ATOM   11080 O O   . SER C 1 420 ? -12.636 54.038  10.312  1.00 52.50  ? 420 SER C O   1 
ATOM   11081 C CB  . SER C 1 420 ? -13.052 51.442  12.336  1.00 48.75  ? 420 SER C CB  1 
ATOM   11082 O OG  . SER C 1 420 ? -11.714 51.896  12.505  1.00 51.30  ? 420 SER C OG  1 
ATOM   11083 N N   . ALA C 1 421 ? -14.277 54.188  11.848  1.00 48.53  ? 421 ALA C N   1 
ATOM   11084 C CA  . ALA C 1 421 ? -14.218 55.636  11.938  1.00 48.74  ? 421 ALA C CA  1 
ATOM   11085 C C   . ALA C 1 421 ? -12.821 56.076  12.348  1.00 51.94  ? 421 ALA C C   1 
ATOM   11086 O O   . ALA C 1 421 ? -12.289 57.024  11.779  1.00 59.78  ? 421 ALA C O   1 
ATOM   11087 C CB  . ALA C 1 421 ? -15.244 56.142  12.920  1.00 54.53  ? 421 ALA C CB  1 
ATOM   11088 N N   . ARG C 1 422 ? -12.242 55.366  13.329  1.00 49.87  ? 422 ARG C N   1 
ATOM   11089 C CA  . ARG C 1 422 ? -11.008 55.788  13.973  1.00 49.82  ? 422 ARG C CA  1 
ATOM   11090 C C   . ARG C 1 422 ? -9.869  55.700  12.962  1.00 53.36  ? 422 ARG C C   1 
ATOM   11091 O O   . ARG C 1 422 ? -9.080  56.624  12.809  1.00 58.19  ? 422 ARG C O   1 
ATOM   11092 C CB  . ARG C 1 422 ? -10.717 54.972  15.245  1.00 48.00  ? 422 ARG C CB  1 
ATOM   11093 C CG  . ARG C 1 422 ? -11.682 55.200  16.408  1.00 50.18  ? 422 ARG C CG  1 
ATOM   11094 C CD  . ARG C 1 422 ? -11.365 54.298  17.613  1.00 52.78  ? 422 ARG C CD  1 
ATOM   11095 N NE  . ARG C 1 422 ? -12.266 54.494  18.759  1.00 53.90  ? 422 ARG C NE  1 
ATOM   11096 C CZ  . ARG C 1 422 ? -12.000 55.067  19.950  1.00 53.74  ? 422 ARG C CZ  1 
ATOM   11097 N NH1 . ARG C 1 422 ? -10.799 55.507  20.259  1.00 59.31  ? 422 ARG C NH1 1 
ATOM   11098 N NH2 . ARG C 1 422 ? -12.958 55.216  20.849  1.00 53.25  ? 422 ARG C NH2 1 
ATOM   11099 N N   . ASP C 1 423 ? -9.811  54.565  12.268  1.00 58.48  ? 423 ASP C N   1 
ATOM   11100 C CA  . ASP C 1 423 ? -8.757  54.299  11.316  1.00 55.04  ? 423 ASP C CA  1 
ATOM   11101 C C   . ASP C 1 423 ? -8.808  55.327  10.192  1.00 51.83  ? 423 ASP C C   1 
ATOM   11102 O O   . ASP C 1 423 ? -7.777  55.836  9.776   1.00 49.04  ? 423 ASP C O   1 
ATOM   11103 C CB  . ASP C 1 423 ? -8.873  52.877  10.790  1.00 61.52  ? 423 ASP C CB  1 
ATOM   11104 C CG  . ASP C 1 423 ? -8.425  51.802  11.764  1.00 57.21  ? 423 ASP C CG  1 
ATOM   11105 O OD1 . ASP C 1 423 ? -7.864  52.168  12.813  1.00 59.41  ? 423 ASP C OD1 1 
ATOM   11106 O OD2 . ASP C 1 423 ? -8.631  50.617  11.452  1.00 55.03  ? 423 ASP C OD2 1 
ATOM   11107 N N   . ARG C 1 424 ? -10.008 55.600  9.679   1.00 50.11  ? 424 ARG C N   1 
ATOM   11108 C CA  . ARG C 1 424 ? -10.149 56.522  8.569   1.00 52.76  ? 424 ARG C CA  1 
ATOM   11109 C C   . ARG C 1 424 ? -9.751  57.917  9.050   1.00 54.35  ? 424 ARG C C   1 
ATOM   11110 O O   . ARG C 1 424 ? -9.031  58.635  8.356   1.00 52.48  ? 424 ARG C O   1 
ATOM   11111 C CB  . ARG C 1 424 ? -11.561 56.463  7.964   1.00 54.03  ? 424 ARG C CB  1 
ATOM   11112 C CG  . ARG C 1 424 ? -11.681 57.317  6.707   1.00 55.18  ? 424 ARG C CG  1 
ATOM   11113 C CD  . ARG C 1 424 ? -12.872 56.993  5.838   1.00 55.45  ? 424 ARG C CD  1 
ATOM   11114 N NE  . ARG C 1 424 ? -14.168 57.265  6.466   1.00 59.55  ? 424 ARG C NE  1 
ATOM   11115 C CZ  . ARG C 1 424 ? -15.340 57.135  5.845   1.00 59.21  ? 424 ARG C CZ  1 
ATOM   11116 N NH1 . ARG C 1 424 ? -15.388 56.700  4.597   1.00 57.56  ? 424 ARG C NH1 1 
ATOM   11117 N NH2 . ARG C 1 424 ? -16.466 57.414  6.481   1.00 57.78  ? 424 ARG C NH2 1 
ATOM   11118 N N   . VAL C 1 425 ? -10.162 58.278  10.269  1.00 53.43  ? 425 VAL C N   1 
ATOM   11119 C CA  . VAL C 1 425 ? -9.848  59.608  10.767  1.00 53.10  ? 425 VAL C CA  1 
ATOM   11120 C C   . VAL C 1 425 ? -8.335  59.729  10.981  1.00 55.19  ? 425 VAL C C   1 
ATOM   11121 O O   . VAL C 1 425 ? -7.757  60.802  10.804  1.00 52.73  ? 425 VAL C O   1 
ATOM   11122 C CB  . VAL C 1 425 ? -10.692 59.965  12.003  1.00 46.57  ? 425 VAL C CB  1 
ATOM   11123 C CG1 . VAL C 1 425 ? -10.109 61.128  12.794  1.00 49.65  ? 425 VAL C CG1 1 
ATOM   11124 C CG2 . VAL C 1 425 ? -12.147 60.249  11.618  1.00 45.33  ? 425 VAL C CG2 1 
ATOM   11125 N N   . SER C 1 426 ? -7.662  58.614  11.267  1.00 51.63  ? 426 SER C N   1 
ATOM   11126 C CA  . SER C 1 426 ? -6.223  58.674  11.473  1.00 57.69  ? 426 SER C CA  1 
ATOM   11127 C C   . SER C 1 426 ? -5.503  58.950  10.149  1.00 48.88  ? 426 SER C C   1 
ATOM   11128 O O   . SER C 1 426 ? -4.340  59.358  10.143  1.00 44.63  ? 426 SER C O   1 
ATOM   11129 C CB  . SER C 1 426 ? -5.694  57.413  12.177  1.00 58.73  ? 426 SER C CB  1 
ATOM   11130 O OG  . SER C 1 426 ? -5.656  56.289  11.308  1.00 61.48  ? 426 SER C OG  1 
ATOM   11131 N N   . ILE C 1 427 ? -6.179  58.702  9.018   1.00 44.87  ? 427 ILE C N   1 
ATOM   11132 C CA  . ILE C 1 427 ? -5.578  59.019  7.734   1.00 50.38  ? 427 ILE C CA  1 
ATOM   11133 C C   . ILE C 1 427 ? -5.593  60.536  7.544   1.00 49.89  ? 427 ILE C C   1 
ATOM   11134 O O   . ILE C 1 427 ? -4.591  61.114  7.126   1.00 47.76  ? 427 ILE C O   1 
ATOM   11135 C CB  . ILE C 1 427 ? -6.268  58.312  6.556   1.00 50.56  ? 427 ILE C CB  1 
ATOM   11136 C CG1 . ILE C 1 427 ? -6.312  56.777  6.707   1.00 51.15  ? 427 ILE C CG1 1 
ATOM   11137 C CG2 . ILE C 1 427 ? -5.579  58.724  5.255   1.00 51.18  ? 427 ILE C CG2 1 
ATOM   11138 C CD1 . ILE C 1 427 ? -7.166  56.078  5.651   1.00 52.06  ? 427 ILE C CD1 1 
ATOM   11139 N N   . PHE C 1 428 ? -6.740  61.154  7.863   1.00 50.29  ? 428 PHE C N   1 
ATOM   11140 C CA  . PHE C 1 428 ? -6.902  62.599  7.797   1.00 57.25  ? 428 PHE C CA  1 
ATOM   11141 C C   . PHE C 1 428 ? -5.858  63.266  8.691   1.00 53.97  ? 428 PHE C C   1 
ATOM   11142 O O   . PHE C 1 428 ? -5.082  64.088  8.205   1.00 51.36  ? 428 PHE C O   1 
ATOM   11143 C CB  . PHE C 1 428 ? -8.326  63.016  8.181   1.00 54.47  ? 428 PHE C CB  1 
ATOM   11144 C CG  . PHE C 1 428 ? -9.437  62.513  7.273   1.00 51.55  ? 428 PHE C CG  1 
ATOM   11145 C CD1 . PHE C 1 428 ? -9.332  62.595  5.890   1.00 60.18  ? 428 PHE C CD1 1 
ATOM   11146 C CD2 . PHE C 1 428 ? -10.603 61.979  7.814   1.00 59.68  ? 428 PHE C CD2 1 
ATOM   11147 C CE1 . PHE C 1 428 ? -10.365 62.153  5.076   1.00 63.30  ? 428 PHE C CE1 1 
ATOM   11148 C CE2 . PHE C 1 428 ? -11.623 61.521  6.996   1.00 61.36  ? 428 PHE C CE2 1 
ATOM   11149 C CZ  . PHE C 1 428 ? -11.499 61.608  5.629   1.00 63.67  ? 428 PHE C CZ  1 
ATOM   11150 N N   . ARG C 1 429 ? -5.818  62.855  9.970   1.00 54.96  ? 429 ARG C N   1 
ATOM   11151 C CA  . ARG C 1 429 ? -4.912  63.415  10.969  1.00 53.65  ? 429 ARG C CA  1 
ATOM   11152 C C   . ARG C 1 429 ? -3.442  63.252  10.577  1.00 51.42  ? 429 ARG C C   1 
ATOM   11153 O O   . ARG C 1 429 ? -2.622  64.115  10.886  1.00 52.26  ? 429 ARG C O   1 
ATOM   11154 C CB  . ARG C 1 429 ? -5.140  62.790  12.350  1.00 48.89  ? 429 ARG C CB  1 
ATOM   11155 C CG  . ARG C 1 429 ? -6.422  63.302  12.981  1.00 50.24  ? 429 ARG C CG  1 
ATOM   11156 C CD  . ARG C 1 429 ? -6.672  62.772  14.374  1.00 50.18  ? 429 ARG C CD  1 
ATOM   11157 N NE  . ARG C 1 429 ? -7.683  63.632  14.998  1.00 56.88  ? 429 ARG C NE  1 
ATOM   11158 C CZ  . ARG C 1 429 ? -7.460  64.867  15.445  1.00 53.97  ? 429 ARG C CZ  1 
ATOM   11159 N NH1 . ARG C 1 429 ? -6.215  65.329  15.542  1.00 49.29  ? 429 ARG C NH1 1 
ATOM   11160 N NH2 . ARG C 1 429 ? -8.483  65.613  15.825  1.00 52.44  ? 429 ARG C NH2 1 
ATOM   11161 N N   . GLN C 1 430 ? -3.097  62.158  9.897   1.00 46.42  ? 430 GLN C N   1 
ATOM   11162 C CA  . GLN C 1 430 ? -1.722  61.979  9.435   1.00 50.01  ? 430 GLN C CA  1 
ATOM   11163 C C   . GLN C 1 430 ? -1.391  63.030  8.363   1.00 50.26  ? 430 GLN C C   1 
ATOM   11164 O O   . GLN C 1 430 ? -0.289  63.582  8.349   1.00 43.29  ? 430 GLN C O   1 
ATOM   11165 C CB  . GLN C 1 430 ? -1.580  60.517  9.010   1.00 46.08  ? 430 GLN C CB  1 
ATOM   11166 C CG  . GLN C 1 430 ? -0.237  60.134  8.409   1.00 48.26  ? 430 GLN C CG  1 
ATOM   11167 C CD  . GLN C 1 430 ? 0.892   60.004  9.412   1.00 48.78  ? 430 GLN C CD  1 
ATOM   11168 O OE1 . GLN C 1 430 ? 2.058   60.263  9.086   1.00 42.41  ? 430 GLN C OE1 1 
ATOM   11169 N NE2 . GLN C 1 430 ? 0.580   59.550  10.618  1.00 46.47  ? 430 GLN C NE2 1 
ATOM   11170 N N   . ILE C 1 431 ? -2.367  63.316  7.490   1.00 47.06  ? 431 ILE C N   1 
ATOM   11171 C CA  . ILE C 1 431 ? -2.235  64.324  6.449   1.00 53.67  ? 431 ILE C CA  1 
ATOM   11172 C C   . ILE C 1 431 ? -2.238  65.737  7.066   1.00 53.91  ? 431 ILE C C   1 
ATOM   11173 O O   . ILE C 1 431 ? -1.408  66.558  6.706   1.00 50.20  ? 431 ILE C O   1 
ATOM   11174 C CB  . ILE C 1 431 ? -3.343  64.106  5.397   1.00 54.49  ? 431 ILE C CB  1 
ATOM   11175 C CG1 . ILE C 1 431 ? -3.129  62.784  4.645   1.00 53.44  ? 431 ILE C CG1 1 
ATOM   11176 C CG2 . ILE C 1 431 ? -3.462  65.287  4.433   1.00 53.03  ? 431 ILE C CG2 1 
ATOM   11177 C CD1 . ILE C 1 431 ? -4.311  62.368  3.793   1.00 50.94  ? 431 ILE C CD1 1 
ATOM   11178 N N   . SER C 1 432 ? -3.141  66.016  8.015   1.00 54.45  ? 432 SER C N   1 
ATOM   11179 C CA  . SER C 1 432 ? -3.217  67.311  8.692   1.00 60.04  ? 432 SER C CA  1 
ATOM   11180 C C   . SER C 1 432 ? -1.926  67.629  9.445   1.00 51.46  ? 432 SER C C   1 
ATOM   11181 O O   . SER C 1 432 ? -1.478  68.768  9.449   1.00 50.33  ? 432 SER C O   1 
ATOM   11182 C CB  . SER C 1 432 ? -4.400  67.390  9.654   1.00 58.42  ? 432 SER C CB  1 
ATOM   11183 O OG  . SER C 1 432 ? -5.628  67.282  8.948   1.00 72.13  ? 432 SER C OG  1 
ATOM   11184 N N   . GLU C 1 433 ? -1.371  66.630  10.127  1.00 45.72  ? 433 GLU C N   1 
ATOM   11185 C CA  . GLU C 1 433 ? -0.148  66.800  10.894  1.00 53.17  ? 433 GLU C CA  1 
ATOM   11186 C C   . GLU C 1 433 ? 0.966   67.279  9.954   1.00 52.56  ? 433 GLU C C   1 
ATOM   11187 O O   . GLU C 1 433 ? 1.649   68.278  10.222  1.00 49.98  ? 433 GLU C O   1 
ATOM   11188 C CB  . GLU C 1 433 ? 0.090   65.433  11.551  1.00 53.87  ? 433 GLU C CB  1 
ATOM   11189 C CG  . GLU C 1 433 ? 1.226   65.365  12.558  1.00 52.06  ? 433 GLU C CG  1 
ATOM   11190 C CD  . GLU C 1 433 ? 0.870   65.897  13.932  1.00 54.31  ? 433 GLU C CD  1 
ATOM   11191 O OE1 . GLU C 1 433 ? 0.076   66.864  14.002  1.00 63.94  ? 433 GLU C OE1 1 
ATOM   11192 O OE2 . GLU C 1 433 ? 1.453   65.387  14.919  1.00 46.07  ? 433 GLU C OE2 1 
ATOM   11193 N N   . ARG C 1 434 ? 1.106   66.588  8.816   1.00 46.62  ? 434 ARG C N   1 
ATOM   11194 C CA  . ARG C 1 434 ? 2.227   66.823  7.917   1.00 53.15  ? 434 ARG C CA  1 
ATOM   11195 C C   . ARG C 1 434 ? 2.064   68.141  7.154   1.00 52.75  ? 434 ARG C C   1 
ATOM   11196 O O   . ARG C 1 434 ? 3.050   68.830  6.917   1.00 57.63  ? 434 ARG C O   1 
ATOM   11197 C CB  . ARG C 1 434 ? 2.396   65.685  6.899   1.00 45.70  ? 434 ARG C CB  1 
ATOM   11198 C CG  . ARG C 1 434 ? 2.909   64.396  7.523   1.00 46.96  ? 434 ARG C CG  1 
ATOM   11199 C CD  . ARG C 1 434 ? 2.615   63.174  6.639   1.00 48.31  ? 434 ARG C CD  1 
ATOM   11200 N NE  . ARG C 1 434 ? 3.110   61.944  7.254   1.00 47.53  ? 434 ARG C NE  1 
ATOM   11201 C CZ  . ARG C 1 434 ? 4.389   61.640  7.393   1.00 49.60  ? 434 ARG C CZ  1 
ATOM   11202 N NH1 . ARG C 1 434 ? 5.301   62.306  6.695   1.00 46.85  ? 434 ARG C NH1 1 
ATOM   11203 N NH2 . ARG C 1 434 ? 4.735   60.651  8.206   1.00 51.85  ? 434 ARG C NH2 1 
ATOM   11204 N N   . TYR C 1 435 ? 0.839   68.483  6.739   1.00 51.75  ? 435 TYR C N   1 
ATOM   11205 C CA  . TYR C 1 435 ? 0.672   69.546  5.754   1.00 55.63  ? 435 TYR C CA  1 
ATOM   11206 C C   . TYR C 1 435 ? -0.250  70.688  6.219   1.00 54.09  ? 435 TYR C C   1 
ATOM   11207 O O   . TYR C 1 435 ? -0.484  71.607  5.447   1.00 57.07  ? 435 TYR C O   1 
ATOM   11208 C CB  . TYR C 1 435 ? 0.217   68.855  4.463   1.00 46.59  ? 435 TYR C CB  1 
ATOM   11209 C CG  . TYR C 1 435 ? 1.063   67.655  4.048   1.00 49.08  ? 435 TYR C CG  1 
ATOM   11210 C CD1 . TYR C 1 435 ? 2.416   67.794  3.760   1.00 54.45  ? 435 TYR C CD1 1 
ATOM   11211 C CD2 . TYR C 1 435 ? 0.509   66.388  3.916   1.00 46.96  ? 435 TYR C CD2 1 
ATOM   11212 C CE1 . TYR C 1 435 ? 3.194   66.709  3.394   1.00 47.72  ? 435 TYR C CE1 1 
ATOM   11213 C CE2 . TYR C 1 435 ? 1.279   65.291  3.566   1.00 49.11  ? 435 TYR C CE2 1 
ATOM   11214 C CZ  . TYR C 1 435 ? 2.622   65.457  3.290   1.00 48.91  ? 435 TYR C CZ  1 
ATOM   11215 O OH  . TYR C 1 435 ? 3.384   64.388  2.925   1.00 49.65  ? 435 TYR C OH  1 
ATOM   11216 N N   . LEU C 1 436 ? -0.786  70.645  7.451   1.00 53.81  ? 436 LEU C N   1 
ATOM   11217 C CA  . LEU C 1 436 ? -1.759  71.631  7.913   1.00 46.65  ? 436 LEU C CA  1 
ATOM   11218 C C   . LEU C 1 436 ? -1.509  71.980  9.379   1.00 44.54  ? 436 LEU C C   1 
ATOM   11219 O O   . LEU C 1 436 ? -2.453  72.313  10.089  1.00 48.49  ? 436 LEU C O   1 
ATOM   11220 C CB  . LEU C 1 436 ? -3.205  71.150  7.739   1.00 50.40  ? 436 LEU C CB  1 
ATOM   11221 C CG  . LEU C 1 436 ? -3.659  70.767  6.323   1.00 51.61  ? 436 LEU C CG  1 
ATOM   11222 C CD1 . LEU C 1 436 ? -5.050  70.173  6.367   1.00 49.93  ? 436 LEU C CD1 1 
ATOM   11223 C CD2 . LEU C 1 436 ? -3.630  71.962  5.375   1.00 52.56  ? 436 LEU C CD2 1 
ATOM   11224 N N   . THR C 1 437 ? -0.242  71.916  9.817   1.00 45.00  ? 437 THR C N   1 
ATOM   11225 C CA  . THR C 1 437 ? 0.167   72.347  11.147  1.00 42.37  ? 437 THR C CA  1 
ATOM   11226 C C   . THR C 1 437 ? 1.452   73.151  11.008  1.00 43.09  ? 437 THR C C   1 
ATOM   11227 O O   . THR C 1 437 ? 2.129   73.054  9.986   1.00 43.00  ? 437 THR C O   1 
ATOM   11228 C CB  . THR C 1 437 ? 0.428   71.176  12.108  1.00 43.01  ? 437 THR C CB  1 
ATOM   11229 O OG1 . THR C 1 437 ? 1.541   70.450  11.590  1.00 42.50  ? 437 THR C OG1 1 
ATOM   11230 C CG2 . THR C 1 437 ? -0.774  70.269  12.308  1.00 42.86  ? 437 THR C CG2 1 
ATOM   11231 N N   . GLN C 1 438 ? 1.812   73.871  12.077  1.00 48.68  ? 438 GLN C N   1 
ATOM   11232 C CA  . GLN C 1 438 ? 3.086   74.561  12.130  1.00 51.21  ? 438 GLN C CA  1 
ATOM   11233 C C   . GLN C 1 438 ? 4.185   73.500  12.070  1.00 46.69  ? 438 GLN C C   1 
ATOM   11234 O O   . GLN C 1 438 ? 5.138   73.616  11.281  1.00 41.97  ? 438 GLN C O   1 
ATOM   11235 C CB  . GLN C 1 438 ? 3.151   75.495  13.341  1.00 55.60  ? 438 GLN C CB  1 
ATOM   11236 C CG  . GLN C 1 438 ? 3.945   76.779  13.069  1.00 72.58  ? 438 GLN C CG  1 
ATOM   11237 C CD  . GLN C 1 438 ? 4.077   77.698  14.276  1.00 78.61  ? 438 GLN C CD  1 
ATOM   11238 O OE1 . GLN C 1 438 ? 3.088   78.189  14.840  1.00 84.76  ? 438 GLN C OE1 1 
ATOM   11239 N NE2 . GLN C 1 438 ? 5.311   77.923  14.704  1.00 71.98  ? 438 GLN C NE2 1 
ATOM   11240 N N   . TRP C 1 439 ? 3.983   72.445  12.875  1.00 50.22  ? 439 TRP C N   1 
ATOM   11241 C CA  . TRP C 1 439 ? 4.906   71.325  12.977  1.00 48.63  ? 439 TRP C CA  1 
ATOM   11242 C C   . TRP C 1 439 ? 5.269   70.858  11.570  1.00 44.09  ? 439 TRP C C   1 
ATOM   11243 O O   . TRP C 1 439 ? 6.443   70.790  11.222  1.00 38.69  ? 439 TRP C O   1 
ATOM   11244 C CB  . TRP C 1 439 ? 4.341   70.174  13.839  1.00 47.58  ? 439 TRP C CB  1 
ATOM   11245 C CG  . TRP C 1 439 ? 5.348   69.066  13.997  1.00 53.27  ? 439 TRP C CG  1 
ATOM   11246 C CD1 . TRP C 1 439 ? 6.338   68.968  14.937  1.00 58.53  ? 439 TRP C CD1 1 
ATOM   11247 C CD2 . TRP C 1 439 ? 5.560   67.969  13.087  1.00 54.15  ? 439 TRP C CD2 1 
ATOM   11248 N NE1 . TRP C 1 439 ? 7.119   67.869  14.704  1.00 54.65  ? 439 TRP C NE1 1 
ATOM   11249 C CE2 . TRP C 1 439 ? 6.670   67.238  13.575  1.00 53.78  ? 439 TRP C CE2 1 
ATOM   11250 C CE3 . TRP C 1 439 ? 4.916   67.536  11.924  1.00 53.02  ? 439 TRP C CE3 1 
ATOM   11251 C CZ2 . TRP C 1 439 ? 7.138   66.092  12.941  1.00 53.18  ? 439 TRP C CZ2 1 
ATOM   11252 C CZ3 . TRP C 1 439 ? 5.391   66.407  11.293  1.00 59.78  ? 439 TRP C CZ3 1 
ATOM   11253 C CH2 . TRP C 1 439 ? 6.501   65.713  11.780  1.00 56.52  ? 439 TRP C CH2 1 
ATOM   11254 N N   . GLY C 1 440 ? 4.255   70.580  10.747  1.00 42.36  ? 440 GLY C N   1 
ATOM   11255 C CA  . GLY C 1 440 ? 4.502   70.085  9.403   1.00 49.44  ? 440 GLY C CA  1 
ATOM   11256 C C   . GLY C 1 440 ? 5.015   71.161  8.439   1.00 50.67  ? 440 GLY C C   1 
ATOM   11257 O O   . GLY C 1 440 ? 5.788   70.871  7.521   1.00 53.14  ? 440 GLY C O   1 
ATOM   11258 N N   . ALA C 1 441 ? 4.553   72.401  8.621   1.00 51.83  ? 441 ALA C N   1 
ATOM   11259 C CA  . ALA C 1 441 ? 4.863   73.480  7.697   1.00 49.52  ? 441 ALA C CA  1 
ATOM   11260 C C   . ALA C 1 441 ? 6.375   73.685  7.634   1.00 46.44  ? 441 ALA C C   1 
ATOM   11261 O O   . ALA C 1 441 ? 6.923   73.928  6.559   1.00 43.62  ? 441 ALA C O   1 
ATOM   11262 C CB  . ALA C 1 441 ? 4.108   74.731  8.113   1.00 52.95  ? 441 ALA C CB  1 
ATOM   11263 N N   . ARG C 1 442 ? 7.055   73.511  8.779   1.00 53.40  ? 442 ARG C N   1 
ATOM   11264 C CA  . ARG C 1 442 ? 8.507   73.571  8.808   1.00 53.73  ? 442 ARG C CA  1 
ATOM   11265 C C   . ARG C 1 442 ? 9.132   72.538  7.866   1.00 65.24  ? 442 ARG C C   1 
ATOM   11266 O O   . ARG C 1 442 ? 10.151  72.834  7.238   1.00 65.00  ? 442 ARG C O   1 
ATOM   11267 C CB  . ARG C 1 442 ? 9.059   73.361  10.218  1.00 56.46  ? 442 ARG C CB  1 
ATOM   11268 C CG  . ARG C 1 442 ? 10.579  73.245  10.253  1.00 63.15  ? 442 ARG C CG  1 
ATOM   11269 C CD  . ARG C 1 442 ? 11.161  71.827  10.091  1.00 65.05  ? 442 ARG C CD  1 
ATOM   11270 N NE  . ARG C 1 442 ? 12.633  71.758  10.158  1.00 66.59  ? 442 ARG C NE  1 
ATOM   11271 C CZ  . ARG C 1 442 ? 13.346  70.651  9.917   1.00 70.33  ? 442 ARG C CZ  1 
ATOM   11272 N NH1 . ARG C 1 442 ? 12.735  69.490  9.757   1.00 67.30  ? 442 ARG C NH1 1 
ATOM   11273 N NH2 . ARG C 1 442 ? 14.669  70.689  9.860   1.00 73.97  ? 442 ARG C NH2 1 
ATOM   11274 N N   . HIS C 1 443 ? 8.573   71.315  7.813   1.00 63.47  ? 443 HIS C N   1 
ATOM   11275 C CA  . HIS C 1 443 ? 9.097   70.295  6.912   1.00 70.31  ? 443 HIS C CA  1 
ATOM   11276 C C   . HIS C 1 443 ? 9.114   70.860  5.482   1.00 68.25  ? 443 HIS C C   1 
ATOM   11277 O O   . HIS C 1 443 ? 10.174  70.939  4.843   1.00 60.04  ? 443 HIS C O   1 
ATOM   11278 C CB  . HIS C 1 443 ? 8.376   68.934  7.049   1.00 65.81  ? 443 HIS C CB  1 
ATOM   11279 C CG  . HIS C 1 443 ? 8.860   67.917  6.042   1.00 75.41  ? 443 HIS C CG  1 
ATOM   11280 N ND1 . HIS C 1 443 ? 8.349   67.806  4.759   1.00 69.44  ? 443 HIS C ND1 1 
ATOM   11281 C CD2 . HIS C 1 443 ? 9.873   67.018  6.110   1.00 77.87  ? 443 HIS C CD2 1 
ATOM   11282 C CE1 . HIS C 1 443 ? 9.010   66.857  4.097   1.00 75.10  ? 443 HIS C CE1 1 
ATOM   11283 N NE2 . HIS C 1 443 ? 9.942   66.362  4.899   1.00 78.17  ? 443 HIS C NE2 1 
ATOM   11284 N N   . GLU C 1 444 ? 7.934   71.269  4.997   1.00 59.50  ? 444 GLU C N   1 
ATOM   11285 C CA  . GLU C 1 444 ? 7.778   71.754  3.634   1.00 69.64  ? 444 GLU C CA  1 
ATOM   11286 C C   . GLU C 1 444 ? 8.671   72.978  3.404   1.00 77.13  ? 444 GLU C C   1 
ATOM   11287 O O   . GLU C 1 444 ? 9.242   73.103  2.318   1.00 78.34  ? 444 GLU C O   1 
ATOM   11288 C CB  . GLU C 1 444 ? 6.313   72.062  3.285   1.00 70.80  ? 444 GLU C CB  1 
ATOM   11289 C CG  . GLU C 1 444 ? 5.376   70.863  3.401   1.00 61.80  ? 444 GLU C CG  1 
ATOM   11290 C CD  . GLU C 1 444 ? 5.943   69.621  2.742   1.00 65.58  ? 444 GLU C CD  1 
ATOM   11291 O OE1 . GLU C 1 444 ? 5.997   69.615  1.491   1.00 69.91  ? 444 GLU C OE1 1 
ATOM   11292 O OE2 . GLU C 1 444 ? 6.395   68.702  3.474   1.00 60.85  ? 444 GLU C OE2 1 
ATOM   11293 N N   . MET C 1 445 ? 8.810   73.857  4.419   1.00 68.77  ? 445 MET C N   1 
ATOM   11294 C CA  . MET C 1 445 ? 9.582   75.085  4.262   1.00 67.63  ? 445 MET C CA  1 
ATOM   11295 C C   . MET C 1 445 ? 11.085  74.803  4.234   1.00 66.60  ? 445 MET C C   1 
ATOM   11296 O O   . MET C 1 445 ? 11.812  75.431  3.454   1.00 56.30  ? 445 MET C O   1 
ATOM   11297 C CB  . MET C 1 445 ? 9.273   76.115  5.355   1.00 65.35  ? 445 MET C CB  1 
ATOM   11298 C CG  . MET C 1 445 ? 7.863   76.672  5.311   1.00 64.92  ? 445 MET C CG  1 
ATOM   11299 S SD  . MET C 1 445 ? 7.371   77.168  3.651   1.00 63.31  ? 445 MET C SD  1 
ATOM   11300 C CE  . MET C 1 445 ? 6.679   75.734  2.806   1.00 65.93  ? 445 MET C CE  1 
ATOM   11301 N N   . PHE C 1 446 ? 11.547  73.872  5.079   1.00 69.25  ? 446 PHE C N   1 
ATOM   11302 C CA  . PHE C 1 446 ? 12.918  73.382  4.991   1.00 70.43  ? 446 PHE C CA  1 
ATOM   11303 C C   . PHE C 1 446 ? 13.182  72.866  3.572   1.00 69.42  ? 446 PHE C C   1 
ATOM   11304 O O   . PHE C 1 446 ? 14.141  73.278  2.934   1.00 56.83  ? 446 PHE C O   1 
ATOM   11305 C CB  . PHE C 1 446 ? 13.202  72.290  6.029   1.00 72.75  ? 446 PHE C CB  1 
ATOM   11306 C CG  . PHE C 1 446 ? 14.584  71.667  5.878   1.00 79.56  ? 446 PHE C CG  1 
ATOM   11307 C CD1 . PHE C 1 446 ? 14.786  70.576  5.025   1.00 77.46  ? 446 PHE C CD1 1 
ATOM   11308 C CD2 . PHE C 1 446 ? 15.682  72.175  6.577   1.00 75.53  ? 446 PHE C CD2 1 
ATOM   11309 C CE1 . PHE C 1 446 ? 16.056  70.024  4.864   1.00 72.43  ? 446 PHE C CE1 1 
ATOM   11310 C CE2 . PHE C 1 446 ? 16.945  71.612  6.414   1.00 75.11  ? 446 PHE C CE2 1 
ATOM   11311 C CZ  . PHE C 1 446 ? 17.127  70.541  5.555   1.00 69.16  ? 446 PHE C CZ  1 
ATOM   11312 N N   . GLU C 1 447 ? 12.312  71.979  3.063   1.00 72.28  ? 447 GLU C N   1 
ATOM   11313 C CA  . GLU C 1 447 ? 12.504  71.390  1.742   1.00 78.69  ? 447 GLU C CA  1 
ATOM   11314 C C   . GLU C 1 447 ? 12.577  72.485  0.669   1.00 77.99  ? 447 GLU C C   1 
ATOM   11315 O O   . GLU C 1 447 ? 13.286  72.336  -0.322  1.00 70.47  ? 447 GLU C O   1 
ATOM   11316 C CB  . GLU C 1 447 ? 11.428  70.353  1.387   1.00 74.22  ? 447 GLU C CB  1 
ATOM   11317 C CG  . GLU C 1 447 ? 11.448  69.088  2.249   1.00 77.23  ? 447 GLU C CG  1 
ATOM   11318 C CD  . GLU C 1 447 ? 12.567  68.082  1.999   1.00 76.56  ? 447 GLU C CD  1 
ATOM   11319 O OE1 . GLU C 1 447 ? 13.753  68.480  1.882   1.00 72.09  ? 447 GLU C OE1 1 
ATOM   11320 O OE2 . GLU C 1 447 ? 12.241  66.875  1.956   1.00 77.96  ? 447 GLU C OE2 1 
ATOM   11321 N N   . LYS C 1 448 ? 11.851  73.592  0.863   1.00 76.34  ? 448 LYS C N   1 
ATOM   11322 C CA  . LYS C 1 448 ? 11.754  74.623  -0.158  1.00 78.84  ? 448 LYS C CA  1 
ATOM   11323 C C   . LYS C 1 448 ? 13.068  75.411  -0.240  1.00 72.93  ? 448 LYS C C   1 
ATOM   11324 O O   . LYS C 1 448 ? 13.547  75.703  -1.340  1.00 64.63  ? 448 LYS C O   1 
ATOM   11325 C CB  . LYS C 1 448 ? 10.525  75.493  0.133   1.00 83.86  ? 448 LYS C CB  1 
ATOM   11326 C CG  . LYS C 1 448 ? 9.801   76.049  -1.079  1.00 90.95  ? 448 LYS C CG  1 
ATOM   11327 C CD  . LYS C 1 448 ? 8.841   75.055  -1.734  1.00 102.89 ? 448 LYS C CD  1 
ATOM   11328 C CE  . LYS C 1 448 ? 7.718   75.717  -2.469  1.00 102.66 ? 448 LYS C CE  1 
ATOM   11329 N NZ  . LYS C 1 448 ? 7.089   76.758  -1.644  1.00 104.61 ? 448 LYS C NZ  1 
ATOM   11330 N N   . PHE C 1 449 ? 13.647  75.766  0.918   1.00 64.24  ? 449 PHE C N   1 
ATOM   11331 C CA  . PHE C 1 449 ? 14.755  76.711  0.942   1.00 73.11  ? 449 PHE C CA  1 
ATOM   11332 C C   . PHE C 1 449 ? 16.021  75.994  1.394   1.00 75.04  ? 449 PHE C C   1 
ATOM   11333 O O   . PHE C 1 449 ? 17.007  76.636  1.728   1.00 72.37  ? 449 PHE C O   1 
ATOM   11334 C CB  . PHE C 1 449 ? 14.416  77.921  1.822   1.00 79.02  ? 449 PHE C CB  1 
ATOM   11335 C CG  . PHE C 1 449 ? 13.073  78.573  1.495   1.00 78.44  ? 449 PHE C CG  1 
ATOM   11336 C CD1 . PHE C 1 449 ? 12.897  79.335  0.340   1.00 74.45  ? 449 PHE C CD1 1 
ATOM   11337 C CD2 . PHE C 1 449 ? 11.982  78.413  2.346   1.00 74.85  ? 449 PHE C CD2 1 
ATOM   11338 C CE1 . PHE C 1 449 ? 11.662  79.898  0.044   1.00 76.71  ? 449 PHE C CE1 1 
ATOM   11339 C CE2 . PHE C 1 449 ? 10.751  78.976  2.046   1.00 75.00  ? 449 PHE C CE2 1 
ATOM   11340 C CZ  . PHE C 1 449 ? 10.593  79.722  0.899   1.00 80.48  ? 449 PHE C CZ  1 
ATOM   11341 N N   . ASN C 1 450 ? 15.958  74.660  1.388   1.00 88.35  ? 450 ASN C N   1 
ATOM   11342 C CA  . ASN C 1 450 ? 17.086  73.775  1.630   1.00 95.46  ? 450 ASN C CA  1 
ATOM   11343 C C   . ASN C 1 450 ? 18.093  73.893  0.487   1.00 97.97  ? 450 ASN C C   1 
ATOM   11344 O O   . ASN C 1 450 ? 17.756  73.602  -0.659  1.00 107.67 ? 450 ASN C O   1 
ATOM   11345 C CB  . ASN C 1 450 ? 16.590  72.334  1.738   1.00 93.75  ? 450 ASN C CB  1 
ATOM   11346 C CG  . ASN C 1 450 ? 17.711  71.330  1.663   1.00 89.65  ? 450 ASN C CG  1 
ATOM   11347 O OD1 . ASN C 1 450 ? 17.593  70.316  0.964   1.00 91.63  ? 450 ASN C OD1 1 
ATOM   11348 N ND2 . ASN C 1 450 ? 18.786  71.595  2.390   1.00 75.84  ? 450 ASN C ND2 1 
ATOM   11349 N N   . GLY C 1 451 ? 19.333  74.289  0.797   1.00 87.98  ? 451 GLY C N   1 
ATOM   11350 C CA  . GLY C 1 451 ? 20.319  74.547  -0.244  1.00 95.10  ? 451 GLY C CA  1 
ATOM   11351 C C   . GLY C 1 451 ? 19.759  75.475  -1.329  1.00 89.14  ? 451 GLY C C   1 
ATOM   11352 O O   . GLY C 1 451 ? 18.982  76.389  -1.034  1.00 82.53  ? 451 GLY C O   1 
ATOM   11353 N N   . THR C 1 452 ? 20.121  75.206  -2.594  1.00 78.57  ? 452 THR C N   1 
ATOM   11354 C CA  . THR C 1 452 ? 19.846  76.136  -3.683  1.00 83.95  ? 452 THR C CA  1 
ATOM   11355 C C   . THR C 1 452 ? 18.373  76.007  -4.098  1.00 73.99  ? 452 THR C C   1 
ATOM   11356 O O   . THR C 1 452 ? 17.917  74.934  -4.485  1.00 58.08  ? 452 THR C O   1 
ATOM   11357 C CB  . THR C 1 452 ? 20.818  75.941  -4.859  1.00 82.99  ? 452 THR C CB  1 
ATOM   11358 O OG1 . THR C 1 452 ? 20.465  74.721  -5.496  1.00 90.53  ? 452 THR C OG1 1 
ATOM   11359 C CG2 . THR C 1 452 ? 22.286  75.927  -4.455  1.00 78.25  ? 452 THR C CG2 1 
ATOM   11360 N N   . PRO C 1 453 ? 17.558  77.086  -4.001  1.00 75.44  ? 453 PRO C N   1 
ATOM   11361 C CA  . PRO C 1 453 ? 16.147  77.015  -4.398  1.00 79.36  ? 453 PRO C CA  1 
ATOM   11362 C C   . PRO C 1 453 ? 15.871  77.049  -5.907  1.00 71.01  ? 453 PRO C C   1 
ATOM   11363 O O   . PRO C 1 453 ? 16.751  77.395  -6.698  1.00 60.84  ? 453 PRO C O   1 
ATOM   11364 C CB  . PRO C 1 453 ? 15.561  78.252  -3.655  1.00 85.27  ? 453 PRO C CB  1 
ATOM   11365 C CG  . PRO C 1 453 ? 16.694  79.263  -3.663  1.00 82.26  ? 453 PRO C CG  1 
ATOM   11366 C CD  . PRO C 1 453 ? 17.942  78.410  -3.476  1.00 76.17  ? 453 PRO C CD  1 
ATOM   11367 N N   . LEU C 1 454 ? 14.614  76.731  -6.268  1.00 72.29  ? 454 LEU C N   1 
ATOM   11368 C CA  . LEU C 1 454 ? 14.146  76.524  -7.637  1.00 69.31  ? 454 LEU C CA  1 
ATOM   11369 C C   . LEU C 1 454 ? 14.605  77.638  -8.585  1.00 68.56  ? 454 LEU C C   1 
ATOM   11370 O O   . LEU C 1 454 ? 15.191  77.346  -9.632  1.00 62.50  ? 454 LEU C O   1 
ATOM   11371 C CB  . LEU C 1 454 ? 12.620  76.375  -7.604  1.00 65.75  ? 454 LEU C CB  1 
ATOM   11372 C CG  . LEU C 1 454 ? 11.895  76.252  -8.950  1.00 65.39  ? 454 LEU C CG  1 
ATOM   11373 C CD1 . LEU C 1 454 ? 12.372  75.084  -9.799  1.00 68.98  ? 454 LEU C CD1 1 
ATOM   11374 C CD2 . LEU C 1 454 ? 10.391  76.160  -8.733  1.00 69.46  ? 454 LEU C CD2 1 
ATOM   11375 N N   . TYR C 1 455 ? 14.328  78.907  -8.239  1.00 69.37  ? 455 TYR C N   1 
ATOM   11376 C CA  . TYR C 1 455 ? 14.621  80.011  -9.143  1.00 69.62  ? 455 TYR C CA  1 
ATOM   11377 C C   . TYR C 1 455 ? 16.134  80.061  -9.362  1.00 66.04  ? 455 TYR C C   1 
ATOM   11378 O O   . TYR C 1 455 ? 16.578  80.493  -10.425 1.00 68.56  ? 455 TYR C O   1 
ATOM   11379 C CB  . TYR C 1 455 ? 14.088  81.373  -8.682  1.00 80.61  ? 455 TYR C CB  1 
ATOM   11380 C CG  . TYR C 1 455 ? 15.036  82.129  -7.760  1.00 92.40  ? 455 TYR C CG  1 
ATOM   11381 C CD1 . TYR C 1 455 ? 15.219  81.719  -6.440  1.00 99.37  ? 455 TYR C CD1 1 
ATOM   11382 C CD2 . TYR C 1 455 ? 15.757  83.236  -8.209  1.00 97.01  ? 455 TYR C CD2 1 
ATOM   11383 C CE1 . TYR C 1 455 ? 16.098  82.377  -5.595  1.00 102.71 ? 455 TYR C CE1 1 
ATOM   11384 C CE2 . TYR C 1 455 ? 16.642  83.900  -7.374  1.00 103.00 ? 455 TYR C CE2 1 
ATOM   11385 C CZ  . TYR C 1 455 ? 16.808  83.468  -6.065  1.00 109.88 ? 455 TYR C CZ  1 
ATOM   11386 O OH  . TYR C 1 455 ? 17.661  84.101  -5.215  1.00 114.98 ? 455 TYR C OH  1 
ATOM   11387 N N   . LEU C 1 456 ? 16.918  79.601  -8.372  1.00 59.70  ? 456 LEU C N   1 
ATOM   11388 C CA  . LEU C 1 456 ? 18.369  79.649  -8.462  1.00 61.44  ? 456 LEU C CA  1 
ATOM   11389 C C   . LEU C 1 456 ? 18.905  78.430  -9.217  1.00 66.52  ? 456 LEU C C   1 
ATOM   11390 O O   . LEU C 1 456 ? 19.941  78.519  -9.885  1.00 60.68  ? 456 LEU C O   1 
ATOM   11391 C CB  . LEU C 1 456 ? 19.007  79.778  -7.080  1.00 67.28  ? 456 LEU C CB  1 
ATOM   11392 C CG  . LEU C 1 456 ? 20.517  80.071  -7.067  1.00 83.58  ? 456 LEU C CG  1 
ATOM   11393 C CD1 . LEU C 1 456 ? 20.833  81.461  -7.608  1.00 83.68  ? 456 LEU C CD1 1 
ATOM   11394 C CD2 . LEU C 1 456 ? 21.138  79.896  -5.678  1.00 89.73  ? 456 LEU C CD2 1 
ATOM   11395 N N   . VAL C 1 457 ? 18.223  77.279  -9.105  1.00 64.97  ? 457 VAL C N   1 
ATOM   11396 C CA  . VAL C 1 457 ? 18.621  76.120  -9.893  1.00 64.02  ? 457 VAL C CA  1 
ATOM   11397 C C   . VAL C 1 457 ? 18.589  76.534  -11.363 1.00 58.35  ? 457 VAL C C   1 
ATOM   11398 O O   . VAL C 1 457 ? 19.476  76.175  -12.129 1.00 55.42  ? 457 VAL C O   1 
ATOM   11399 C CB  . VAL C 1 457 ? 17.771  74.857  -9.642  1.00 62.19  ? 457 VAL C CB  1 
ATOM   11400 C CG1 . VAL C 1 457 ? 18.017  73.774  -10.689 1.00 64.14  ? 457 VAL C CG1 1 
ATOM   11401 C CG2 . VAL C 1 457 ? 18.003  74.303  -8.243  1.00 64.67  ? 457 VAL C CG2 1 
ATOM   11402 N N   . ARG C 1 458 ? 17.563  77.319  -11.708 1.00 61.64  ? 458 ARG C N   1 
ATOM   11403 C CA  . ARG C 1 458 ? 17.291  77.744  -13.069 1.00 63.95  ? 458 ARG C CA  1 
ATOM   11404 C C   . ARG C 1 458 ? 18.425  78.629  -13.561 1.00 69.21  ? 458 ARG C C   1 
ATOM   11405 O O   . ARG C 1 458 ? 18.977  78.382  -14.627 1.00 83.21  ? 458 ARG C O   1 
ATOM   11406 C CB  . ARG C 1 458 ? 15.945  78.473  -13.157 1.00 59.37  ? 458 ARG C CB  1 
ATOM   11407 C CG  . ARG C 1 458 ? 14.720  77.595  -12.960 1.00 56.02  ? 458 ARG C CG  1 
ATOM   11408 C CD  . ARG C 1 458 ? 13.445  78.419  -13.142 1.00 58.62  ? 458 ARG C CD  1 
ATOM   11409 N NE  . ARG C 1 458 ? 12.246  77.573  -13.135 1.00 58.63  ? 458 ARG C NE  1 
ATOM   11410 C CZ  . ARG C 1 458 ? 11.066  77.774  -12.545 1.00 55.56  ? 458 ARG C CZ  1 
ATOM   11411 N NH1 . ARG C 1 458 ? 10.863  78.758  -11.685 1.00 57.56  ? 458 ARG C NH1 1 
ATOM   11412 N NH2 . ARG C 1 458 ? 10.065  76.961  -12.835 1.00 56.98  ? 458 ARG C NH2 1 
ATOM   11413 N N   . LEU C 1 459 ? 18.782  79.645  -12.775 1.00 68.63  ? 459 LEU C N   1 
ATOM   11414 C CA  . LEU C 1 459 ? 19.800  80.594  -13.203 1.00 77.31  ? 459 LEU C CA  1 
ATOM   11415 C C   . LEU C 1 459 ? 21.171  79.909  -13.285 1.00 73.25  ? 459 LEU C C   1 
ATOM   11416 O O   . LEU C 1 459 ? 21.971  80.221  -14.166 1.00 76.82  ? 459 LEU C O   1 
ATOM   11417 C CB  . LEU C 1 459 ? 19.769  81.823  -12.289 1.00 78.06  ? 459 LEU C CB  1 
ATOM   11418 C CG  . LEU C 1 459 ? 18.431  82.584  -12.241 1.00 88.94  ? 459 LEU C CG  1 
ATOM   11419 C CD1 . LEU C 1 459 ? 18.511  83.793  -11.306 1.00 91.53  ? 459 LEU C CD1 1 
ATOM   11420 C CD2 . LEU C 1 459 ? 17.906  83.022  -13.620 1.00 86.62  ? 459 LEU C CD2 1 
ATOM   11421 N N   . LEU C 1 460 ? 21.421  78.931  -12.405 1.00 76.76  ? 460 LEU C N   1 
ATOM   11422 C CA  . LEU C 1 460 ? 22.671  78.182  -12.403 1.00 68.78  ? 460 LEU C CA  1 
ATOM   11423 C C   . LEU C 1 460 ? 22.723  77.191  -13.566 1.00 66.90  ? 460 LEU C C   1 
ATOM   11424 O O   . LEU C 1 460 ? 23.804  76.873  -14.066 1.00 63.78  ? 460 LEU C O   1 
ATOM   11425 C CB  . LEU C 1 460 ? 22.838  77.432  -11.084 1.00 75.33  ? 460 LEU C CB  1 
ATOM   11426 C CG  . LEU C 1 460 ? 23.278  78.253  -9.871  1.00 82.19  ? 460 LEU C CG  1 
ATOM   11427 C CD1 . LEU C 1 460 ? 23.498  77.283  -8.714  1.00 84.01  ? 460 LEU C CD1 1 
ATOM   11428 C CD2 . LEU C 1 460 ? 24.521  79.091  -10.144 1.00 77.41  ? 460 LEU C CD2 1 
ATOM   11429 N N   . THR C 1 461 ? 21.563  76.664  -13.973 1.00 64.36  ? 461 THR C N   1 
ATOM   11430 C CA  . THR C 1 461 ? 21.545  75.648  -15.013 1.00 62.87  ? 461 THR C CA  1 
ATOM   11431 C C   . THR C 1 461 ? 22.213  76.249  -16.244 1.00 59.64  ? 461 THR C C   1 
ATOM   11432 O O   . THR C 1 461 ? 23.021  75.581  -16.884 1.00 58.42  ? 461 THR C O   1 
ATOM   11433 C CB  . THR C 1 461 ? 20.122  75.147  -15.293 1.00 59.78  ? 461 THR C CB  1 
ATOM   11434 O OG1 . THR C 1 461 ? 19.690  74.423  -14.142 1.00 52.59  ? 461 THR C OG1 1 
ATOM   11435 C CG2 . THR C 1 461 ? 20.046  74.233  -16.506 1.00 60.98  ? 461 THR C CG2 1 
ATOM   11436 N N   . MET C 1 462 ? 21.894  77.526  -16.513 1.00 53.59  ? 462 MET C N   1 
ATOM   11437 C CA  . MET C 1 462 ? 22.231  78.163  -17.765 1.00 53.19  ? 462 MET C CA  1 
ATOM   11438 C C   . MET C 1 462 ? 23.660  78.675  -17.717 1.00 60.89  ? 462 MET C C   1 
ATOM   11439 O O   . MET C 1 462 ? 24.197  79.034  -18.758 1.00 58.94  ? 462 MET C O   1 
ATOM   11440 C CB  . MET C 1 462 ? 21.295  79.328  -18.092 1.00 62.65  ? 462 MET C CB  1 
ATOM   11441 C CG  . MET C 1 462 ? 19.830  78.956  -18.222 1.00 66.15  ? 462 MET C CG  1 
ATOM   11442 S SD  . MET C 1 462 ? 19.504  77.467  -19.191 1.00 62.93  ? 462 MET C SD  1 
ATOM   11443 C CE  . MET C 1 462 ? 20.234  77.954  -20.760 1.00 69.72  ? 462 MET C CE  1 
ATOM   11444 N N   . GLN C 1 463 ? 24.279  78.687  -16.529 1.00 65.65  ? 463 GLN C N   1 
ATOM   11445 C CA  . GLN C 1 463 ? 25.675  79.090  -16.427 1.00 67.61  ? 463 GLN C CA  1 
ATOM   11446 C C   . GLN C 1 463 ? 26.594  77.910  -16.735 1.00 67.05  ? 463 GLN C C   1 
ATOM   11447 O O   . GLN C 1 463 ? 27.789  78.115  -16.938 1.00 68.32  ? 463 GLN C O   1 
ATOM   11448 C CB  . GLN C 1 463 ? 26.018  79.724  -15.076 1.00 70.15  ? 463 GLN C CB  1 
ATOM   11449 C CG  . GLN C 1 463 ? 25.405  81.103  -14.862 1.00 69.74  ? 463 GLN C CG  1 
ATOM   11450 C CD  . GLN C 1 463 ? 25.636  81.617  -13.458 1.00 78.96  ? 463 GLN C CD  1 
ATOM   11451 O OE1 . GLN C 1 463 ? 26.433  81.052  -12.698 1.00 86.53  ? 463 GLN C OE1 1 
ATOM   11452 N NE2 . GLN C 1 463 ? 24.933  82.683  -13.091 1.00 74.62  ? 463 GLN C NE2 1 
ATOM   11453 N N   . ARG C 1 464 ? 26.042  76.688  -16.776 1.00 69.49  ? 464 ARG C N   1 
ATOM   11454 C CA  . ARG C 1 464 ? 26.840  75.494  -17.017 1.00 65.31  ? 464 ARG C CA  1 
ATOM   11455 C C   . ARG C 1 464 ? 27.338  75.444  -18.462 1.00 68.24  ? 464 ARG C C   1 
ATOM   11456 O O   . ARG C 1 464 ? 26.632  75.836  -19.391 1.00 63.12  ? 464 ARG C O   1 
ATOM   11457 C CB  . ARG C 1 464 ? 26.071  74.203  -16.723 1.00 66.89  ? 464 ARG C CB  1 
ATOM   11458 C CG  . ARG C 1 464 ? 26.053  73.724  -15.280 1.00 66.38  ? 464 ARG C CG  1 
ATOM   11459 C CD  . ARG C 1 464 ? 25.006  72.637  -15.177 1.00 71.41  ? 464 ARG C CD  1 
ATOM   11460 N NE  . ARG C 1 464 ? 24.954  71.948  -13.883 1.00 83.80  ? 464 ARG C NE  1 
ATOM   11461 C CZ  . ARG C 1 464 ? 25.873  71.107  -13.441 1.00 76.11  ? 464 ARG C CZ  1 
ATOM   11462 N NH1 . ARG C 1 464 ? 26.986  70.927  -14.126 1.00 68.17  ? 464 ARG C NH1 1 
ATOM   11463 N NH2 . ARG C 1 464 ? 25.662  70.451  -12.319 1.00 80.01  ? 464 ARG C NH2 1 
ATOM   11464 N N   . THR C 1 465 ? 28.553  74.894  -18.614 1.00 73.82  ? 465 THR C N   1 
ATOM   11465 C CA  . THR C 1 465 ? 29.246  74.752  -19.893 1.00 78.82  ? 465 THR C CA  1 
ATOM   11466 C C   . THR C 1 465 ? 28.404  73.903  -20.857 1.00 69.73  ? 465 THR C C   1 
ATOM   11467 O O   . THR C 1 465 ? 28.290  74.235  -22.038 1.00 65.49  ? 465 THR C O   1 
ATOM   11468 C CB  . THR C 1 465 ? 30.696  74.251  -19.690 1.00 75.96  ? 465 THR C CB  1 
ATOM   11469 O OG1 . THR C 1 465 ? 31.023  73.366  -20.758 1.00 78.50  ? 465 THR C OG1 1 
ATOM   11470 C CG2 . THR C 1 465 ? 30.975  73.480  -18.407 1.00 75.48  ? 465 THR C CG2 1 
ATOM   11471 N N   . GLU C 1 466 ? 27.767  72.844  -20.341 1.00 66.14  ? 466 GLU C N   1 
ATOM   11472 C CA  . GLU C 1 466 ? 26.909  71.970  -21.134 1.00 71.85  ? 466 GLU C CA  1 
ATOM   11473 C C   . GLU C 1 466 ? 25.842  72.780  -21.890 1.00 63.63  ? 466 GLU C C   1 
ATOM   11474 O O   . GLU C 1 466 ? 25.494  72.398  -23.010 1.00 66.96  ? 466 GLU C O   1 
ATOM   11475 C CB  . GLU C 1 466 ? 26.301  70.833  -20.288 1.00 73.11  ? 466 GLU C CB  1 
ATOM   11476 C CG  . GLU C 1 466 ? 27.300  69.781  -19.783 1.00 81.54  ? 466 GLU C CG  1 
ATOM   11477 C CD  . GLU C 1 466 ? 28.005  69.933  -18.421 1.00 85.44  ? 466 GLU C CD  1 
ATOM   11478 O OE1 . GLU C 1 466 ? 28.282  71.077  -17.981 1.00 82.88  ? 466 GLU C OE1 1 
ATOM   11479 O OE2 . GLU C 1 466 ? 28.338  68.886  -17.796 1.00 76.31  ? 466 GLU C OE2 1 
ATOM   11480 N N   . TYR C 1 467 ? 25.335  73.894  -21.315 1.00 58.38  ? 467 TYR C N   1 
ATOM   11481 C CA  . TYR C 1 467 ? 24.073  74.490  -21.773 1.00 62.71  ? 467 TYR C CA  1 
ATOM   11482 C C   . TYR C 1 467 ? 24.267  75.876  -22.407 1.00 57.33  ? 467 TYR C C   1 
ATOM   11483 O O   . TYR C 1 467 ? 23.293  76.581  -22.662 1.00 59.92  ? 467 TYR C O   1 
ATOM   11484 C CB  . TYR C 1 467 ? 23.043  74.541  -20.631 1.00 56.27  ? 467 TYR C CB  1 
ATOM   11485 C CG  . TYR C 1 467 ? 22.685  73.167  -20.090 1.00 51.17  ? 467 TYR C CG  1 
ATOM   11486 C CD1 . TYR C 1 467 ? 22.351  72.136  -20.950 1.00 50.53  ? 467 TYR C CD1 1 
ATOM   11487 C CD2 . TYR C 1 467 ? 22.793  72.868  -18.742 1.00 52.79  ? 467 TYR C CD2 1 
ATOM   11488 C CE1 . TYR C 1 467 ? 22.056  70.868  -20.492 1.00 57.42  ? 467 TYR C CE1 1 
ATOM   11489 C CE2 . TYR C 1 467 ? 22.525  71.595  -18.267 1.00 55.32  ? 467 TYR C CE2 1 
ATOM   11490 C CZ  . TYR C 1 467 ? 22.138  70.592  -19.142 1.00 61.32  ? 467 TYR C CZ  1 
ATOM   11491 O OH  . TYR C 1 467 ? 21.841  69.322  -18.717 1.00 56.66  ? 467 TYR C OH  1 
ATOM   11492 N N   . GLN C 1 468 ? 25.518  76.231  -22.701 1.00 53.61  ? 468 GLN C N   1 
ATOM   11493 C CA  . GLN C 1 468 ? 25.864  77.486  -23.337 1.00 54.32  ? 468 GLN C CA  1 
ATOM   11494 C C   . GLN C 1 468 ? 25.544  77.438  -24.825 1.00 56.85  ? 468 GLN C C   1 
ATOM   11495 O O   . GLN C 1 468 ? 25.452  76.361  -25.406 1.00 56.63  ? 468 GLN C O   1 
ATOM   11496 C CB  . GLN C 1 468 ? 27.376  77.723  -23.266 1.00 60.93  ? 468 GLN C CB  1 
ATOM   11497 C CG  . GLN C 1 468 ? 27.929  77.901  -21.855 1.00 62.54  ? 468 GLN C CG  1 
ATOM   11498 C CD  . GLN C 1 468 ? 27.295  79.052  -21.103 1.00 67.76  ? 468 GLN C CD  1 
ATOM   11499 O OE1 . GLN C 1 468 ? 26.375  78.856  -20.301 1.00 72.51  ? 468 GLN C OE1 1 
ATOM   11500 N NE2 . GLN C 1 468 ? 27.771  80.263  -21.359 1.00 66.62  ? 468 GLN C NE2 1 
ATOM   11501 N N   . VAL C 1 469 ? 25.466  78.634  -25.432 1.00 59.77  ? 469 VAL C N   1 
ATOM   11502 C CA  . VAL C 1 469 ? 25.130  78.809  -26.835 1.00 59.04  ? 469 VAL C CA  1 
ATOM   11503 C C   . VAL C 1 469 ? 26.089  78.000  -27.723 1.00 60.96  ? 469 VAL C C   1 
ATOM   11504 O O   . VAL C 1 469 ? 25.642  77.314  -28.641 1.00 61.73  ? 469 VAL C O   1 
ATOM   11505 C CB  . VAL C 1 469 ? 25.110  80.312  -27.200 1.00 62.66  ? 469 VAL C CB  1 
ATOM   11506 C CG1 . VAL C 1 469 ? 24.676  80.541  -28.644 1.00 68.61  ? 469 VAL C CG1 1 
ATOM   11507 C CG2 . VAL C 1 469 ? 24.220  81.141  -26.272 1.00 68.91  ? 469 VAL C CG2 1 
ATOM   11508 N N   . ASP C 1 470 ? 27.404  78.056  -27.451 1.00 60.89  ? 470 ASP C N   1 
ATOM   11509 C CA  . ASP C 1 470 ? 28.409  77.380  -28.266 1.00 67.88  ? 470 ASP C CA  1 
ATOM   11510 C C   . ASP C 1 470 ? 28.671  75.963  -27.750 1.00 71.01  ? 470 ASP C C   1 
ATOM   11511 O O   . ASP C 1 470 ? 29.622  75.305  -28.168 1.00 72.43  ? 470 ASP C O   1 
ATOM   11512 C CB  . ASP C 1 470 ? 29.704  78.178  -28.324 1.00 74.30  ? 470 ASP C CB  1 
ATOM   11513 C CG  . ASP C 1 470 ? 29.731  79.271  -29.379 1.00 85.19  ? 470 ASP C CG  1 
ATOM   11514 O OD1 . ASP C 1 470 ? 29.861  78.923  -30.571 1.00 89.66  ? 470 ASP C OD1 1 
ATOM   11515 O OD2 . ASP C 1 470 ? 29.602  80.456  -28.997 1.00 98.98  ? 470 ASP C OD2 1 
ATOM   11516 N N   . GLY C 1 471 ? 27.810  75.490  -26.848 1.00 68.52  ? 471 GLY C N   1 
ATOM   11517 C CA  . GLY C 1 471 ? 28.006  74.211  -26.196 1.00 71.92  ? 471 GLY C CA  1 
ATOM   11518 C C   . GLY C 1 471 ? 27.255  73.090  -26.908 1.00 67.00  ? 471 GLY C C   1 
ATOM   11519 O O   . GLY C 1 471 ? 26.551  73.311  -27.888 1.00 60.80  ? 471 GLY C O   1 
ATOM   11520 N N   . PRO C 1 472 ? 27.371  71.845  -26.403 1.00 71.59  ? 472 PRO C N   1 
ATOM   11521 C CA  . PRO C 1 472 ? 26.950  70.672  -27.160 1.00 72.97  ? 472 PRO C CA  1 
ATOM   11522 C C   . PRO C 1 472 ? 25.441  70.603  -27.337 1.00 61.63  ? 472 PRO C C   1 
ATOM   11523 O O   . PRO C 1 472 ? 24.981  70.004  -28.292 1.00 65.34  ? 472 PRO C O   1 
ATOM   11524 C CB  . PRO C 1 472 ? 27.522  69.515  -26.316 1.00 80.19  ? 472 PRO C CB  1 
ATOM   11525 C CG  . PRO C 1 472 ? 27.473  70.051  -24.901 1.00 88.88  ? 472 PRO C CG  1 
ATOM   11526 C CD  . PRO C 1 472 ? 27.908  71.502  -25.075 1.00 82.91  ? 472 PRO C CD  1 
ATOM   11527 N N   . LEU C 1 473 ? 24.680  71.269  -26.465 1.00 67.01  ? 473 LEU C N   1 
ATOM   11528 C CA  . LEU C 1 473 ? 23.229  71.190  -26.512 1.00 64.52  ? 473 LEU C CA  1 
ATOM   11529 C C   . LEU C 1 473 ? 22.663  71.854  -27.770 1.00 63.54  ? 473 LEU C C   1 
ATOM   11530 O O   . LEU C 1 473 ? 21.505  71.593  -28.087 1.00 69.42  ? 473 LEU C O   1 
ATOM   11531 C CB  . LEU C 1 473 ? 22.599  71.783  -25.253 1.00 70.67  ? 473 LEU C CB  1 
ATOM   11532 C CG  . LEU C 1 473 ? 21.130  71.412  -24.996 1.00 75.87  ? 473 LEU C CG  1 
ATOM   11533 C CD1 . LEU C 1 473 ? 20.969  70.014  -24.421 1.00 69.84  ? 473 LEU C CD1 1 
ATOM   11534 C CD2 . LEU C 1 473 ? 20.443  72.434  -24.098 1.00 78.82  ? 473 LEU C CD2 1 
ATOM   11535 N N   . THR C 1 474 ? 23.440  72.690  -28.489 1.00 60.62  ? 474 THR C N   1 
ATOM   11536 C CA  . THR C 1 474 ? 22.957  73.281  -29.740 1.00 61.38  ? 474 THR C CA  1 
ATOM   11537 C C   . THR C 1 474 ? 23.553  72.585  -30.962 1.00 61.11  ? 474 THR C C   1 
ATOM   11538 O O   . THR C 1 474 ? 23.278  73.030  -32.074 1.00 57.44  ? 474 THR C O   1 
ATOM   11539 C CB  . THR C 1 474 ? 23.224  74.787  -29.881 1.00 54.56  ? 474 THR C CB  1 
ATOM   11540 O OG1 . THR C 1 474 ? 24.624  75.006  -30.029 1.00 53.46  ? 474 THR C OG1 1 
ATOM   11541 C CG2 . THR C 1 474 ? 22.655  75.603  -28.740 1.00 54.08  ? 474 THR C CG2 1 
ATOM   11542 N N   . ASP C 1 475 ? 24.372  71.537  -30.767 1.00 65.36  ? 475 ASP C N   1 
ATOM   11543 C CA  . ASP C 1 475 ? 24.999  70.837  -31.887 1.00 69.14  ? 475 ASP C CA  1 
ATOM   11544 C C   . ASP C 1 475 ? 23.927  70.366  -32.877 1.00 64.61  ? 475 ASP C C   1 
ATOM   11545 O O   . ASP C 1 475 ? 24.050  70.619  -34.075 1.00 61.90  ? 475 ASP C O   1 
ATOM   11546 C CB  . ASP C 1 475 ? 25.977  69.754  -31.433 1.00 63.82  ? 475 ASP C CB  1 
ATOM   11547 C CG  . ASP C 1 475 ? 27.362  70.236  -30.998 1.00 70.41  ? 475 ASP C CG  1 
ATOM   11548 O OD1 . ASP C 1 475 ? 27.762  71.363  -31.380 1.00 75.57  ? 475 ASP C OD1 1 
ATOM   11549 O OD2 . ASP C 1 475 ? 28.031  69.503  -30.248 1.00 64.18  ? 475 ASP C OD2 1 
ATOM   11550 N N   . LEU C 1 476 ? 22.854  69.734  -32.377 1.00 60.15  ? 476 LEU C N   1 
ATOM   11551 C CA  . LEU C 1 476 ? 21.799  69.238  -33.248 1.00 57.98  ? 476 LEU C CA  1 
ATOM   11552 C C   . LEU C 1 476 ? 21.113  70.404  -33.976 1.00 56.70  ? 476 LEU C C   1 
ATOM   11553 O O   . LEU C 1 476 ? 20.923  70.355  -35.197 1.00 52.95  ? 476 LEU C O   1 
ATOM   11554 C CB  . LEU C 1 476 ? 20.805  68.357  -32.484 1.00 59.59  ? 476 LEU C CB  1 
ATOM   11555 C CG  . LEU C 1 476 ? 19.612  67.833  -33.301 1.00 64.77  ? 476 LEU C CG  1 
ATOM   11556 C CD1 . LEU C 1 476 ? 20.066  66.984  -34.482 1.00 64.68  ? 476 LEU C CD1 1 
ATOM   11557 C CD2 . LEU C 1 476 ? 18.635  67.050  -32.448 1.00 62.93  ? 476 LEU C CD2 1 
ATOM   11558 N N   . ALA C 1 477 ? 20.743  71.463  -33.240 1.00 55.69  ? 477 ALA C N   1 
ATOM   11559 C CA  . ALA C 1 477 ? 20.080  72.606  -33.854 1.00 55.16  ? 477 ALA C CA  1 
ATOM   11560 C C   . ALA C 1 477 ? 20.960  73.237  -34.937 1.00 52.60  ? 477 ALA C C   1 
ATOM   11561 O O   . ALA C 1 477 ? 20.447  73.661  -35.967 1.00 48.95  ? 477 ALA C O   1 
ATOM   11562 C CB  . ALA C 1 477 ? 19.685  73.617  -32.803 1.00 56.15  ? 477 ALA C CB  1 
ATOM   11563 N N   . ARG C 1 478 ? 22.284  73.283  -34.706 1.00 61.52  ? 478 ARG C N   1 
ATOM   11564 C CA  . ARG C 1 478 ? 23.229  73.860  -35.653 1.00 61.90  ? 478 ARG C CA  1 
ATOM   11565 C C   . ARG C 1 478 ? 23.254  73.027  -36.934 1.00 62.36  ? 478 ARG C C   1 
ATOM   11566 O O   . ARG C 1 478 ? 23.195  73.603  -38.020 1.00 59.12  ? 478 ARG C O   1 
ATOM   11567 C CB  . ARG C 1 478 ? 24.649  74.005  -35.080 1.00 65.12  ? 478 ARG C CB  1 
ATOM   11568 C CG  . ARG C 1 478 ? 24.816  75.140  -34.081 1.00 62.27  ? 478 ARG C CG  1 
ATOM   11569 C CD  . ARG C 1 478 ? 26.209  75.231  -33.460 1.00 64.21  ? 478 ARG C CD  1 
ATOM   11570 N NE  . ARG C 1 478 ? 26.232  76.156  -32.313 1.00 74.50  ? 478 ARG C NE  1 
ATOM   11571 C CZ  . ARG C 1 478 ? 26.203  77.505  -32.315 1.00 74.46  ? 478 ARG C CZ  1 
ATOM   11572 N NH1 . ARG C 1 478 ? 26.314  78.196  -33.444 1.00 70.93  ? 478 ARG C NH1 1 
ATOM   11573 N NH2 . ARG C 1 478 ? 26.083  78.169  -31.170 1.00 66.63  ? 478 ARG C NH2 1 
ATOM   11574 N N   . GLN C 1 479 ? 23.332  71.686  -36.818 1.00 62.61  ? 479 GLN C N   1 
ATOM   11575 C CA  . GLN C 1 479 ? 23.505  70.854  -38.004 1.00 68.61  ? 479 GLN C CA  1 
ATOM   11576 C C   . GLN C 1 479 ? 22.261  70.983  -38.895 1.00 60.11  ? 479 GLN C C   1 
ATOM   11577 O O   . GLN C 1 479 ? 22.402  71.077  -40.107 1.00 53.38  ? 479 GLN C O   1 
ATOM   11578 C CB  . GLN C 1 479 ? 24.005  69.431  -37.717 1.00 72.32  ? 479 GLN C CB  1 
ATOM   11579 C CG  . GLN C 1 479 ? 23.002  68.509  -37.030 1.00 89.43  ? 479 GLN C CG  1 
ATOM   11580 C CD  . GLN C 1 479 ? 23.334  67.033  -37.156 1.00 93.97  ? 479 GLN C CD  1 
ATOM   11581 O OE1 . GLN C 1 479 ? 24.364  66.553  -36.667 1.00 79.70  ? 479 GLN C OE1 1 
ATOM   11582 N NE2 . GLN C 1 479 ? 22.442  66.291  -37.803 1.00 89.86  ? 479 GLN C NE2 1 
ATOM   11583 N N   . VAL C 1 480 ? 21.071  71.077  -38.281 1.00 58.63  ? 480 VAL C N   1 
ATOM   11584 C CA  . VAL C 1 480 ? 19.795  71.266  -38.967 1.00 60.68  ? 480 VAL C CA  1 
ATOM   11585 C C   . VAL C 1 480 ? 19.745  72.597  -39.737 1.00 63.11  ? 480 VAL C C   1 
ATOM   11586 O O   . VAL C 1 480 ? 19.191  72.682  -40.837 1.00 60.08  ? 480 VAL C O   1 
ATOM   11587 C CB  . VAL C 1 480 ? 18.714  71.188  -37.861 1.00 68.23  ? 480 VAL C CB  1 
ATOM   11588 C CG1 . VAL C 1 480 ? 17.380  71.817  -38.256 1.00 62.71  ? 480 VAL C CG1 1 
ATOM   11589 C CG2 . VAL C 1 480 ? 18.503  69.760  -37.359 1.00 74.04  ? 480 VAL C CG2 1 
ATOM   11590 N N   . LEU C 1 481 ? 20.281  73.661  -39.132 1.00 57.50  ? 481 LEU C N   1 
ATOM   11591 C CA  . LEU C 1 481 ? 20.270  74.986  -39.728 1.00 57.27  ? 481 LEU C CA  1 
ATOM   11592 C C   . LEU C 1 481 ? 21.443  75.159  -40.686 1.00 54.57  ? 481 LEU C C   1 
ATOM   11593 O O   . LEU C 1 481 ? 21.419  76.077  -41.478 1.00 57.16  ? 481 LEU C O   1 
ATOM   11594 C CB  . LEU C 1 481 ? 20.331  76.027  -38.611 1.00 56.92  ? 481 LEU C CB  1 
ATOM   11595 C CG  . LEU C 1 481 ? 19.046  76.194  -37.798 1.00 57.84  ? 481 LEU C CG  1 
ATOM   11596 C CD1 . LEU C 1 481 ? 19.351  76.870  -36.477 1.00 54.80  ? 481 LEU C CD1 1 
ATOM   11597 C CD2 . LEU C 1 481 ? 17.991  76.966  -38.598 1.00 60.05  ? 481 LEU C CD2 1 
ATOM   11598 N N   . GLY C 1 482 ? 22.471  74.308  -40.596 1.00 55.48  ? 482 GLY C N   1 
ATOM   11599 C CA  . GLY C 1 482 ? 23.662  74.451  -41.422 1.00 60.28  ? 482 GLY C CA  1 
ATOM   11600 C C   . GLY C 1 482 ? 24.548  75.597  -40.925 1.00 62.58  ? 482 GLY C C   1 
ATOM   11601 O O   . GLY C 1 482 ? 25.012  76.417  -41.704 1.00 55.17  ? 482 GLY C O   1 
ATOM   11602 N N   . PHE C 1 483 ? 24.762  75.648  -39.610 1.00 66.41  ? 483 PHE C N   1 
ATOM   11603 C CA  . PHE C 1 483 ? 25.482  76.728  -38.966 1.00 70.55  ? 483 PHE C CA  1 
ATOM   11604 C C   . PHE C 1 483 ? 26.801  76.201  -38.405 1.00 72.97  ? 483 PHE C C   1 
ATOM   11605 O O   . PHE C 1 483 ? 26.826  75.106  -37.848 1.00 72.51  ? 483 PHE C O   1 
ATOM   11606 C CB  . PHE C 1 483 ? 24.668  77.292  -37.793 1.00 70.10  ? 483 PHE C CB  1 
ATOM   11607 C CG  . PHE C 1 483 ? 23.536  78.267  -38.089 1.00 63.30  ? 483 PHE C CG  1 
ATOM   11608 C CD1 . PHE C 1 483 ? 23.266  78.715  -39.378 1.00 66.85  ? 483 PHE C CD1 1 
ATOM   11609 C CD2 . PHE C 1 483 ? 22.779  78.786  -37.042 1.00 62.51  ? 483 PHE C CD2 1 
ATOM   11610 C CE1 . PHE C 1 483 ? 22.229  79.605  -39.610 1.00 64.22  ? 483 PHE C CE1 1 
ATOM   11611 C CE2 . PHE C 1 483 ? 21.758  79.692  -37.281 1.00 54.97  ? 483 PHE C CE2 1 
ATOM   11612 C CZ  . PHE C 1 483 ? 21.478  80.087  -38.562 1.00 58.83  ? 483 PHE C CZ  1 
ATOM   11613 N N   . GLY C 1 484 ? 27.867  77.010  -38.522 1.00 69.34  ? 484 GLY C N   1 
ATOM   11614 C CA  . GLY C 1 484 ? 29.054  76.870  -37.690 1.00 74.90  ? 484 GLY C CA  1 
ATOM   11615 C C   . GLY C 1 484 ? 28.803  77.429  -36.285 1.00 74.29  ? 484 GLY C C   1 
ATOM   11616 O O   . GLY C 1 484 ? 27.652  77.501  -35.851 1.00 71.72  ? 484 GLY C O   1 
ATOM   11617 N N   . ASP C 1 485 ? 29.881  77.830  -35.588 1.00 79.98  ? 485 ASP C N   1 
ATOM   11618 C CA  . ASP C 1 485 ? 29.797  78.411  -34.248 1.00 78.46  ? 485 ASP C CA  1 
ATOM   11619 C C   . ASP C 1 485 ? 29.389  79.891  -34.325 1.00 72.87  ? 485 ASP C C   1 
ATOM   11620 O O   . ASP C 1 485 ? 29.127  80.422  -35.402 1.00 66.47  ? 485 ASP C O   1 
ATOM   11621 C CB  . ASP C 1 485 ? 31.051  78.108  -33.429 1.00 79.20  ? 485 ASP C CB  1 
ATOM   11622 C CG  . ASP C 1 485 ? 32.389  78.637  -33.938 1.00 80.94  ? 485 ASP C CG  1 
ATOM   11623 O OD1 . ASP C 1 485 ? 32.434  79.161  -35.068 1.00 93.40  ? 485 ASP C OD1 1 
ATOM   11624 O OD2 . ASP C 1 485 ? 33.387  78.519  -33.194 1.00 74.08  ? 485 ASP C OD2 1 
ATOM   11625 N N   . THR C 1 486 ? 29.295  80.556  -33.164 1.00 82.04  ? 486 THR C N   1 
ATOM   11626 C CA  . THR C 1 486 ? 28.847  81.942  -33.118 1.00 92.24  ? 486 THR C CA  1 
ATOM   11627 C C   . THR C 1 486 ? 29.893  82.874  -33.741 1.00 91.55  ? 486 THR C C   1 
ATOM   11628 O O   . THR C 1 486 ? 29.547  83.982  -34.144 1.00 86.90  ? 486 THR C O   1 
ATOM   11629 C CB  . THR C 1 486 ? 28.473  82.369  -31.695 1.00 92.03  ? 486 THR C CB  1 
ATOM   11630 O OG1 . THR C 1 486 ? 29.533  81.941  -30.851 1.00 97.22  ? 486 THR C OG1 1 
ATOM   11631 C CG2 . THR C 1 486 ? 27.162  81.762  -31.228 1.00 93.00  ? 486 THR C CG2 1 
ATOM   11632 N N   . GLU C 1 487 ? 31.159  82.436  -33.835 1.00 94.89  ? 487 GLU C N   1 
ATOM   11633 C CA  . GLU C 1 487 ? 32.162  83.201  -34.565 1.00 101.52 ? 487 GLU C CA  1 
ATOM   11634 C C   . GLU C 1 487 ? 31.933  83.031  -36.067 1.00 94.84  ? 487 GLU C C   1 
ATOM   11635 O O   . GLU C 1 487 ? 31.817  84.024  -36.779 1.00 100.85 ? 487 GLU C O   1 
ATOM   11636 C CB  . GLU C 1 487 ? 33.615  82.861  -34.218 1.00 105.30 ? 487 GLU C CB  1 
ATOM   11637 C CG  . GLU C 1 487 ? 34.598  83.870  -34.811 1.00 109.85 ? 487 GLU C CG  1 
ATOM   11638 C CD  . GLU C 1 487 ? 36.070  83.573  -34.590 1.00 113.91 ? 487 GLU C CD  1 
ATOM   11639 O OE1 . GLU C 1 487 ? 36.823  83.392  -35.583 1.00 109.39 ? 487 GLU C OE1 1 
ATOM   11640 O OE2 . GLU C 1 487 ? 36.451  83.550  -33.399 1.00 98.85  ? 487 GLU C OE2 1 
ATOM   11641 N N   . ALA C 1 488 ? 31.878  81.774  -36.540 1.00 92.89  ? 488 ALA C N   1 
ATOM   11642 C CA  . ALA C 1 488 ? 31.628  81.482  -37.945 1.00 83.36  ? 488 ALA C CA  1 
ATOM   11643 C C   . ALA C 1 488 ? 30.402  82.260  -38.419 1.00 78.90  ? 488 ALA C C   1 
ATOM   11644 O O   . ALA C 1 488 ? 30.429  82.818  -39.511 1.00 72.77  ? 488 ALA C O   1 
ATOM   11645 C CB  . ALA C 1 488 ? 31.472  79.987  -38.184 1.00 76.26  ? 488 ALA C CB  1 
ATOM   11646 N N   . LEU C 1 489 ? 29.351  82.294  -37.582 1.00 80.67  ? 489 LEU C N   1 
ATOM   11647 C CA  . LEU C 1 489 ? 28.089  82.954  -37.898 1.00 79.96  ? 489 LEU C CA  1 
ATOM   11648 C C   . LEU C 1 489 ? 28.249  84.473  -37.955 1.00 72.71  ? 489 LEU C C   1 
ATOM   11649 O O   . LEU C 1 489 ? 27.690  85.117  -38.837 1.00 63.16  ? 489 LEU C O   1 
ATOM   11650 C CB  . LEU C 1 489 ? 27.039  82.586  -36.848 1.00 85.11  ? 489 LEU C CB  1 
ATOM   11651 C CG  . LEU C 1 489 ? 26.157  81.368  -37.140 1.00 83.68  ? 489 LEU C CG  1 
ATOM   11652 C CD1 . LEU C 1 489 ? 25.347  80.991  -35.903 1.00 79.41  ? 489 LEU C CD1 1 
ATOM   11653 C CD2 . LEU C 1 489 ? 25.244  81.672  -38.318 1.00 82.11  ? 489 LEU C CD2 1 
ATOM   11654 N N   . ALA C 1 490 ? 28.949  85.033  -36.958 1.00 75.55  ? 490 ALA C N   1 
ATOM   11655 C CA  . ALA C 1 490 ? 29.181  86.466  -36.848 1.00 81.21  ? 490 ALA C CA  1 
ATOM   11656 C C   . ALA C 1 490 ? 30.073  86.953  -37.990 1.00 86.90  ? 490 ALA C C   1 
ATOM   11657 O O   . ALA C 1 490 ? 29.928  88.091  -38.447 1.00 81.30  ? 490 ALA C O   1 
ATOM   11658 C CB  . ALA C 1 490 ? 29.796  86.785  -35.496 1.00 84.68  ? 490 ALA C CB  1 
ATOM   11659 N N   . ALA C 1 491 ? 30.987  86.071  -38.426 1.00 83.83  ? 491 ALA C N   1 
ATOM   11660 C CA  . ALA C 1 491 ? 31.901  86.321  -39.531 1.00 78.46  ? 491 ALA C CA  1 
ATOM   11661 C C   . ALA C 1 491 ? 31.145  86.479  -40.848 1.00 75.33  ? 491 ALA C C   1 
ATOM   11662 O O   . ALA C 1 491 ? 31.475  87.353  -41.645 1.00 82.39  ? 491 ALA C O   1 
ATOM   11663 C CB  . ALA C 1 491 ? 32.907  85.193  -39.613 1.00 79.30  ? 491 ALA C CB  1 
ATOM   11664 N N   . ARG C 1 492 ? 30.140  85.626  -41.086 1.00 74.72  ? 492 ARG C N   1 
ATOM   11665 C CA  . ARG C 1 492 ? 29.319  85.739  -42.282 1.00 79.45  ? 492 ARG C CA  1 
ATOM   11666 C C   . ARG C 1 492 ? 28.486  87.023  -42.222 1.00 80.71  ? 492 ARG C C   1 
ATOM   11667 O O   . ARG C 1 492 ? 28.169  87.600  -43.265 1.00 82.09  ? 492 ARG C O   1 
ATOM   11668 C CB  . ARG C 1 492 ? 28.440  84.495  -42.463 1.00 87.43  ? 492 ARG C CB  1 
ATOM   11669 C CG  . ARG C 1 492 ? 27.768  84.349  -43.827 1.00 94.61  ? 492 ARG C CG  1 
ATOM   11670 C CD  . ARG C 1 492 ? 26.654  83.291  -43.857 1.00 97.70  ? 492 ARG C CD  1 
ATOM   11671 N NE  . ARG C 1 492 ? 26.919  82.113  -43.015 1.00 94.68  ? 492 ARG C NE  1 
ATOM   11672 C CZ  . ARG C 1 492 ? 26.040  81.155  -42.724 1.00 105.50 ? 492 ARG C CZ  1 
ATOM   11673 N NH1 . ARG C 1 492 ? 24.915  81.066  -43.412 1.00 110.41 ? 492 ARG C NH1 1 
ATOM   11674 N NH2 . ARG C 1 492 ? 26.294  80.263  -41.774 1.00 103.96 ? 492 ARG C NH2 1 
ATOM   11675 N N   . ALA C 1 493 ? 28.121  87.451  -41.000 1.00 78.91  ? 493 ALA C N   1 
ATOM   11676 C CA  . ALA C 1 493 ? 27.360  88.675  -40.780 1.00 71.97  ? 493 ALA C CA  1 
ATOM   11677 C C   . ALA C 1 493 ? 28.162  89.897  -41.223 1.00 77.13  ? 493 ALA C C   1 
ATOM   11678 O O   . ALA C 1 493 ? 27.630  90.750  -41.937 1.00 71.70  ? 493 ALA C O   1 
ATOM   11679 C CB  . ALA C 1 493 ? 26.972  88.791  -39.325 1.00 67.85  ? 493 ALA C CB  1 
ATOM   11680 N N   . ALA C 1 494 ? 29.431  89.956  -40.777 1.00 88.16  ? 494 ALA C N   1 
ATOM   11681 C CA  . ALA C 1 494 ? 30.371  91.027  -41.092 1.00 92.02  ? 494 ALA C CA  1 
ATOM   11682 C C   . ALA C 1 494 ? 30.774  91.005  -42.569 1.00 93.20  ? 494 ALA C C   1 
ATOM   11683 O O   . ALA C 1 494 ? 31.086  92.052  -43.136 1.00 93.98  ? 494 ALA C O   1 
ATOM   11684 C CB  . ALA C 1 494 ? 31.595  90.928  -40.194 1.00 87.38  ? 494 ALA C CB  1 
ATOM   11685 N N   . GLU C 1 495 ? 30.777  89.815  -43.181 1.00 92.80  ? 495 GLU C N   1 
ATOM   11686 C CA  . GLU C 1 495 ? 31.113  89.666  -44.588 1.00 101.25 ? 495 GLU C CA  1 
ATOM   11687 C C   . GLU C 1 495 ? 30.025  90.295  -45.466 1.00 105.86 ? 495 GLU C C   1 
ATOM   11688 O O   . GLU C 1 495 ? 30.360  90.909  -46.478 1.00 123.31 ? 495 GLU C O   1 
ATOM   11689 C CB  . GLU C 1 495 ? 31.388  88.191  -44.899 1.00 105.03 ? 495 GLU C CB  1 
ATOM   11690 C CG  . GLU C 1 495 ? 31.837  87.903  -46.332 1.00 113.01 ? 495 GLU C CG  1 
ATOM   11691 C CD  . GLU C 1 495 ? 32.217  86.446  -46.594 1.00 118.96 ? 495 GLU C CD  1 
ATOM   11692 O OE1 . GLU C 1 495 ? 31.401  85.546  -46.263 1.00 99.74  ? 495 GLU C OE1 1 
ATOM   11693 O OE2 . GLU C 1 495 ? 33.324  86.204  -47.138 1.00 112.36 ? 495 GLU C OE2 1 
ATOM   11694 N N   . VAL C 1 496 ? 28.738  90.160  -45.088 1.00 105.83 ? 496 VAL C N   1 
ATOM   11695 C CA  . VAL C 1 496 ? 27.637  90.635  -45.927 1.00 100.48 ? 496 VAL C CA  1 
ATOM   11696 C C   . VAL C 1 496 ? 27.470  92.149  -45.762 1.00 94.97  ? 496 VAL C C   1 
ATOM   11697 O O   . VAL C 1 496 ? 26.860  92.786  -46.615 1.00 90.80  ? 496 VAL C O   1 
ATOM   11698 C CB  . VAL C 1 496 ? 26.270  89.930  -45.760 1.00 94.81  ? 496 VAL C CB  1 
ATOM   11699 C CG1 . VAL C 1 496 ? 26.282  88.501  -46.296 1.00 90.79  ? 496 VAL C CG1 1 
ATOM   11700 C CG2 . VAL C 1 496 ? 25.759  89.962  -44.325 1.00 100.60 ? 496 VAL C CG2 1 
ATOM   11701 N N   . GLU C 1 497 ? 27.998  92.732  -44.677 1.00 94.64  ? 497 GLU C N   1 
ATOM   11702 C CA  . GLU C 1 497 ? 28.090  94.183  -44.570 1.00 103.13 ? 497 GLU C CA  1 
ATOM   11703 C C   . GLU C 1 497 ? 29.071  94.710  -45.621 1.00 108.95 ? 497 GLU C C   1 
ATOM   11704 O O   . GLU C 1 497 ? 28.684  95.491  -46.489 1.00 111.39 ? 497 GLU C O   1 
ATOM   11705 C CB  . GLU C 1 497 ? 28.415  94.632  -43.143 1.00 99.39  ? 497 GLU C CB  1 
ATOM   11706 C CG  . GLU C 1 497 ? 27.178  94.645  -42.247 1.00 101.70 ? 497 GLU C CG  1 
ATOM   11707 C CD  . GLU C 1 497 ? 27.414  95.095  -40.818 1.00 107.10 ? 497 GLU C CD  1 
ATOM   11708 O OE1 . GLU C 1 497 ? 28.129  96.107  -40.671 1.00 105.43 ? 497 GLU C OE1 1 
ATOM   11709 O OE2 . GLU C 1 497 ? 26.883  94.466  -39.867 1.00 100.25 ? 497 GLU C OE2 1 
ATOM   11710 N N   . LYS C 1 498 ? 30.327  94.247  -45.561 1.00 113.54 ? 498 LYS C N   1 
ATOM   11711 C CA  . LYS C 1 498 ? 31.341  94.586  -46.553 1.00 115.72 ? 498 LYS C CA  1 
ATOM   11712 C C   . LYS C 1 498 ? 31.062  93.846  -47.881 1.00 103.27 ? 498 LYS C C   1 
ATOM   11713 O O   . LYS C 1 498 ? 30.066  94.197  -48.569 1.00 84.23  ? 498 LYS C O   1 
ATOM   11714 C CB  . LYS C 1 498 ? 32.729  94.203  -46.021 1.00 120.59 ? 498 LYS C CB  1 
ATOM   11715 C CG  . LYS C 1 498 ? 33.140  94.830  -44.686 1.00 124.01 ? 498 LYS C CG  1 
ATOM   11716 C CD  . LYS C 1 498 ? 34.092  93.955  -43.875 1.00 125.46 ? 498 LYS C CD  1 
ATOM   11717 C CE  . LYS C 1 498 ? 34.559  94.584  -42.602 1.00 121.55 ? 498 LYS C CE  1 
ATOM   11718 N NZ  . LYS C 1 498 ? 35.287  93.609  -41.788 1.00 114.15 ? 498 LYS C NZ  1 
HETATM 11719 O O   . HOH D 2 .   ? -14.945 19.713  -8.478  1.00 67.94  ? 601 HOH A O   1 
HETATM 11720 O O   . HOH D 2 .   ? 27.008  18.998  -29.591 1.00 46.81  ? 602 HOH A O   1 
HETATM 11721 O O   . HOH D 2 .   ? 0.714   14.115  0.818   1.00 45.26  ? 603 HOH A O   1 
HETATM 11722 O O   . HOH D 2 .   ? -7.833  11.179  -37.511 1.00 42.72  ? 604 HOH A O   1 
HETATM 11723 O O   . HOH D 2 .   ? 39.358  9.872   -8.700  1.00 58.66  ? 605 HOH A O   1 
HETATM 11724 O O   . HOH D 2 .   ? 12.976  4.974   -34.426 1.00 36.06  ? 606 HOH A O   1 
HETATM 11725 O O   . HOH D 2 .   ? 23.201  17.024  -9.219  1.00 37.45  ? 607 HOH A O   1 
HETATM 11726 O O   . HOH D 2 .   ? 8.369   5.548   -15.607 1.00 32.80  ? 608 HOH A O   1 
HETATM 11727 O O   . HOH D 2 .   ? -10.588 25.064  -24.877 1.00 40.00  ? 609 HOH A O   1 
HETATM 11728 O O   . HOH D 2 .   ? 42.938  11.626  -29.671 1.00 50.89  ? 610 HOH A O   1 
HETATM 11729 O O   . HOH D 2 .   ? 25.233  -17.176 24.130  1.00 48.43  ? 611 HOH A O   1 
HETATM 11730 O O   . HOH D 2 .   ? -15.227 6.557   -35.556 1.00 33.44  ? 612 HOH A O   1 
HETATM 11731 O O   . HOH D 2 .   ? -3.636  17.723  -36.803 1.00 40.59  ? 613 HOH A O   1 
HETATM 11732 O O   . HOH D 2 .   ? 36.300  10.619  -34.443 1.00 47.41  ? 614 HOH A O   1 
HETATM 11733 O O   . HOH D 2 .   ? 43.625  7.242   -12.525 1.00 43.18  ? 615 HOH A O   1 
HETATM 11734 O O   . HOH D 2 .   ? 26.084  -10.711 -23.436 1.00 39.49  ? 616 HOH A O   1 
HETATM 11735 O O   . HOH D 2 .   ? -13.616 23.567  -33.897 1.00 53.06  ? 617 HOH A O   1 
HETATM 11736 O O   . HOH D 2 .   ? 24.187  4.915   -8.006  1.00 49.80  ? 618 HOH A O   1 
HETATM 11737 O O   . HOH D 2 .   ? 37.044  4.759   -13.508 1.00 46.66  ? 619 HOH A O   1 
HETATM 11738 O O   . HOH D 2 .   ? 25.847  14.643  -20.344 1.00 43.11  ? 620 HOH A O   1 
HETATM 11739 O O   . HOH D 2 .   ? 28.140  14.076  -29.434 1.00 37.92  ? 621 HOH A O   1 
HETATM 11740 O O   . HOH D 2 .   ? 2.835   16.928  -27.001 1.00 44.00  ? 622 HOH A O   1 
HETATM 11741 O O   . HOH D 2 .   ? 33.451  21.733  -30.113 1.00 44.71  ? 623 HOH A O   1 
HETATM 11742 O O   . HOH D 2 .   ? 20.292  9.327   -28.821 1.00 38.63  ? 624 HOH A O   1 
HETATM 11743 O O   . HOH D 2 .   ? -4.083  15.526  -29.111 1.00 43.53  ? 625 HOH A O   1 
HETATM 11744 O O   . HOH D 2 .   ? 26.772  -9.657  -37.240 1.00 38.11  ? 626 HOH A O   1 
HETATM 11745 O O   . HOH D 2 .   ? 39.278  5.833   -30.146 1.00 43.66  ? 627 HOH A O   1 
HETATM 11746 O O   . HOH D 2 .   ? 49.523  -15.343 -22.416 1.00 59.75  ? 628 HOH A O   1 
HETATM 11747 O O   . HOH D 2 .   ? 13.540  9.524   -8.279  1.00 43.63  ? 629 HOH A O   1 
HETATM 11748 O O   . HOH D 2 .   ? 10.213  18.310  -10.890 1.00 37.64  ? 630 HOH A O   1 
HETATM 11749 O O   . HOH D 2 .   ? 4.527   3.115   -15.137 1.00 48.27  ? 631 HOH A O   1 
HETATM 11750 O O   . HOH D 2 .   ? 20.008  3.693   15.413  1.00 38.37  ? 632 HOH A O   1 
HETATM 11751 O O   . HOH D 2 .   ? 5.723   9.892   -20.301 1.00 36.42  ? 633 HOH A O   1 
HETATM 11752 O O   . HOH D 2 .   ? 29.149  6.818   -2.635  1.00 54.78  ? 634 HOH A O   1 
HETATM 11753 O O   . HOH D 2 .   ? 10.378  7.764   -37.431 1.00 40.44  ? 635 HOH A O   1 
HETATM 11754 O O   . HOH D 2 .   ? 29.097  6.630   -37.463 1.00 49.17  ? 636 HOH A O   1 
HETATM 11755 O O   . HOH D 2 .   ? 5.494   7.199   -20.847 1.00 38.25  ? 637 HOH A O   1 
HETATM 11756 O O   . HOH D 2 .   ? 2.490   6.052   -39.550 1.00 38.28  ? 638 HOH A O   1 
HETATM 11757 O O   . HOH D 2 .   ? 20.205  12.988  -8.631  1.00 36.26  ? 639 HOH A O   1 
HETATM 11758 O O   . HOH D 2 .   ? 21.709  4.443   -42.036 1.00 36.57  ? 640 HOH A O   1 
HETATM 11759 O O   . HOH D 2 .   ? 24.917  -16.488 26.643  1.00 47.67  ? 641 HOH A O   1 
HETATM 11760 O O   . HOH D 2 .   ? 22.344  21.204  -39.304 1.00 46.41  ? 642 HOH A O   1 
HETATM 11761 O O   . HOH D 2 .   ? 24.482  16.895  -11.735 1.00 43.15  ? 643 HOH A O   1 
HETATM 11762 O O   . HOH D 2 .   ? 10.331  6.241   -27.466 1.00 33.80  ? 644 HOH A O   1 
HETATM 11763 O O   . HOH D 2 .   ? 28.414  8.486   -3.669  1.00 49.43  ? 645 HOH A O   1 
HETATM 11764 O O   . HOH D 2 .   ? -17.076 9.970   -37.286 1.00 38.23  ? 646 HOH A O   1 
HETATM 11765 O O   . HOH D 2 .   ? 10.479  -6.214  -31.422 1.00 30.13  ? 647 HOH A O   1 
HETATM 11766 O O   . HOH D 2 .   ? 1.125   5.593   -30.444 1.00 49.41  ? 648 HOH A O   1 
HETATM 11767 O O   . HOH D 2 .   ? 44.528  -15.346 -29.103 1.00 57.03  ? 649 HOH A O   1 
HETATM 11768 O O   . HOH D 2 .   ? 7.156   2.654   -37.783 1.00 52.09  ? 650 HOH A O   1 
HETATM 11769 O O   . HOH D 2 .   ? -16.227 22.397  -28.200 1.00 44.11  ? 651 HOH A O   1 
HETATM 11770 O O   . HOH D 2 .   ? -0.035  1.444   -13.612 1.00 54.51  ? 652 HOH A O   1 
HETATM 11771 O O   . HOH D 2 .   ? 25.331  15.221  -13.841 1.00 49.07  ? 653 HOH A O   1 
HETATM 11772 O O   . HOH D 2 .   ? 49.519  0.865   -26.295 1.00 53.18  ? 654 HOH A O   1 
HETATM 11773 O O   . HOH D 2 .   ? 35.573  20.744  -16.573 1.00 46.62  ? 655 HOH A O   1 
HETATM 11774 O O   . HOH D 2 .   ? 11.751  7.217   -35.145 1.00 40.39  ? 656 HOH A O   1 
HETATM 11775 O O   . HOH D 2 .   ? 9.626   6.087   -25.228 1.00 38.14  ? 657 HOH A O   1 
HETATM 11776 O O   . HOH D 2 .   ? 21.079  15.339  -8.200  1.00 36.79  ? 658 HOH A O   1 
HETATM 11777 O O   . HOH D 2 .   ? 8.218   9.513   -36.920 1.00 48.68  ? 659 HOH A O   1 
HETATM 11778 O O   . HOH D 2 .   ? -6.959  21.916  -7.282  1.00 63.48  ? 660 HOH A O   1 
HETATM 11779 O O   . HOH D 2 .   ? -10.465 6.010   -28.407 1.00 61.55  ? 661 HOH A O   1 
HETATM 11780 O O   . HOH D 2 .   ? 30.517  7.665   -39.334 1.00 53.05  ? 662 HOH A O   1 
HETATM 11781 O O   . HOH D 2 .   ? 8.840   23.636  -17.864 1.00 49.06  ? 663 HOH A O   1 
HETATM 11782 O O   . HOH D 2 .   ? -18.132 11.535  -36.309 1.00 41.10  ? 664 HOH A O   1 
HETATM 11783 O O   . HOH D 2 .   ? -7.706  8.049   -26.084 1.00 62.80  ? 665 HOH A O   1 
HETATM 11784 O O   . HOH D 2 .   ? 1.690   2.769   -30.027 1.00 37.44  ? 666 HOH A O   1 
HETATM 11785 O O   . HOH D 2 .   ? 35.333  19.277  -18.414 1.00 45.68  ? 667 HOH A O   1 
HETATM 11786 O O   . HOH D 2 .   ? 41.239  7.253   -30.031 1.00 40.22  ? 668 HOH A O   1 
HETATM 11787 O O   . HOH D 2 .   ? 5.556   1.219   -14.556 1.00 53.76  ? 669 HOH A O   1 
HETATM 11788 O O   . HOH D 2 .   ? 37.726  4.648   -34.003 1.00 55.98  ? 670 HOH A O   1 
HETATM 11789 O O   . HOH D 2 .   ? -16.994 17.207  -6.948  1.00 61.15  ? 671 HOH A O   1 
HETATM 11790 O O   . HOH D 2 .   ? 31.321  5.880   -37.555 1.00 50.28  ? 672 HOH A O   1 
HETATM 11791 O O   . HOH D 2 .   ? -17.197 15.900  -8.909  1.00 52.08  ? 673 HOH A O   1 
HETATM 11792 O O   . HOH D 2 .   ? 2.526   2.099   -15.352 1.00 50.78  ? 674 HOH A O   1 
HETATM 11793 O O   . HOH E 2 .   ? 12.473  73.354  -55.230 1.00 66.62  ? 601 HOH B O   1 
HETATM 11794 O O   . HOH E 2 .   ? 4.745   37.514  -28.652 1.00 55.62  ? 602 HOH B O   1 
HETATM 11795 O O   . HOH E 2 .   ? 25.257  85.367  -39.785 1.00 48.38  ? 603 HOH B O   1 
HETATM 11796 O O   . HOH E 2 .   ? 17.723  78.333  -51.540 1.00 53.71  ? 604 HOH B O   1 
HETATM 11797 O O   . HOH E 2 .   ? 9.217   54.445  -43.554 1.00 46.36  ? 605 HOH B O   1 
HETATM 11798 O O   . HOH E 2 .   ? -10.721 48.690  -38.405 1.00 52.57  ? 606 HOH B O   1 
HETATM 11799 O O   . HOH E 2 .   ? 5.554   66.500  -30.567 1.00 43.90  ? 607 HOH B O   1 
HETATM 11800 O O   . HOH E 2 .   ? 13.939  46.576  -44.299 1.00 42.05  ? 608 HOH B O   1 
HETATM 11801 O O   . HOH E 2 .   ? 6.608   89.918  -50.391 1.00 51.01  ? 609 HOH B O   1 
HETATM 11802 O O   . HOH E 2 .   ? 2.743   57.854  12.171  1.00 48.63  ? 610 HOH B O   1 
HETATM 11803 O O   . HOH E 2 .   ? 4.780   61.652  -49.394 1.00 43.58  ? 611 HOH B O   1 
HETATM 11804 O O   . HOH E 2 .   ? 17.026  50.357  -26.699 1.00 45.50  ? 612 HOH B O   1 
HETATM 11805 O O   . HOH E 2 .   ? 18.539  64.524  -25.726 1.00 55.97  ? 613 HOH B O   1 
HETATM 11806 O O   . HOH E 2 .   ? 7.447   69.235  -35.647 1.00 45.43  ? 614 HOH B O   1 
HETATM 11807 O O   . HOH E 2 .   ? 7.452   64.300  -52.249 1.00 52.95  ? 615 HOH B O   1 
HETATM 11808 O O   . HOH E 2 .   ? 9.364   61.304  -23.230 1.00 49.69  ? 616 HOH B O   1 
HETATM 11809 O O   . HOH E 2 .   ? 5.953   35.279  -44.951 1.00 53.52  ? 617 HOH B O   1 
HETATM 11810 O O   . HOH E 2 .   ? 6.108   72.358  -54.453 1.00 48.22  ? 618 HOH B O   1 
HETATM 11811 O O   . HOH E 2 .   ? 3.686   54.756  0.728   1.00 46.91  ? 619 HOH B O   1 
HETATM 11812 O O   . HOH E 2 .   ? 9.856   69.178  -35.008 1.00 49.20  ? 620 HOH B O   1 
HETATM 11813 O O   . HOH E 2 .   ? 7.285   62.960  -50.093 1.00 50.01  ? 621 HOH B O   1 
HETATM 11814 O O   . HOH E 2 .   ? 22.418  90.827  -43.113 1.00 47.76  ? 622 HOH B O   1 
HETATM 11815 O O   . HOH E 2 .   ? -6.259  64.167  -46.294 1.00 47.38  ? 623 HOH B O   1 
HETATM 11816 O O   . HOH E 2 .   ? 6.341   81.441  -46.353 1.00 51.41  ? 624 HOH B O   1 
HETATM 11817 O O   . HOH E 2 .   ? 20.703  39.252  -31.588 1.00 55.81  ? 625 HOH B O   1 
HETATM 11818 O O   . HOH E 2 .   ? 21.466  51.509  -18.523 1.00 62.67  ? 626 HOH B O   1 
HETATM 11819 O O   . HOH E 2 .   ? 19.141  39.439  -33.303 1.00 52.14  ? 627 HOH B O   1 
HETATM 11820 O O   . HOH E 2 .   ? 7.477   33.500  -44.867 1.00 51.12  ? 628 HOH B O   1 
HETATM 11821 O O   . HOH E 2 .   ? 28.208  42.473  -34.269 1.00 46.99  ? 629 HOH B O   1 
HETATM 11822 O O   . HOH E 2 .   ? 19.268  62.108  -25.565 1.00 60.23  ? 630 HOH B O   1 
HETATM 11823 O O   . HOH E 2 .   ? 20.855  96.169  -36.080 1.00 82.88  ? 631 HOH B O   1 
HETATM 11824 O O   . HOH F 2 .   ? 26.826  55.756  14.792  1.00 60.20  ? 601 HOH C O   1 
HETATM 11825 O O   . HOH F 2 .   ? 26.195  85.445  8.603   1.00 52.25  ? 602 HOH C O   1 
HETATM 11826 O O   . HOH F 2 .   ? -15.242 68.212  20.651  1.00 42.57  ? 603 HOH C O   1 
HETATM 11827 O O   . HOH F 2 .   ? -10.599 49.905  9.908   1.00 51.78  ? 604 HOH C O   1 
HETATM 11828 O O   . HOH F 2 .   ? 25.975  60.074  5.459   1.00 53.10  ? 605 HOH C O   1 
HETATM 11829 O O   . HOH F 2 .   ? 26.097  54.019  16.745  1.00 70.53  ? 606 HOH C O   1 
HETATM 11830 O O   . HOH F 2 .   ? 20.194  70.873  -30.314 1.00 53.07  ? 607 HOH C O   1 
HETATM 11831 O O   . HOH F 2 .   ? 26.704  84.423  22.200  1.00 53.23  ? 608 HOH C O   1 
HETATM 11832 O O   . HOH F 2 .   ? 6.587   63.787  -14.897 1.00 39.16  ? 609 HOH C O   1 
HETATM 11833 O O   . HOH F 2 .   ? 10.186  56.542  -3.873  1.00 46.89  ? 610 HOH C O   1 
HETATM 11834 O O   . HOH F 2 .   ? 21.807  70.414  27.087  1.00 45.22  ? 611 HOH C O   1 
HETATM 11835 O O   . HOH F 2 .   ? -17.120 64.894  22.400  1.00 48.29  ? 612 HOH C O   1 
HETATM 11836 O O   . HOH F 2 .   ? 2.458   68.773  24.621  1.00 43.22  ? 613 HOH C O   1 
HETATM 11837 O O   . HOH F 2 .   ? 10.444  80.991  16.599  1.00 37.40  ? 614 HOH C O   1 
HETATM 11838 O O   . HOH F 2 .   ? -18.175 63.324  21.303  1.00 52.67  ? 615 HOH C O   1 
HETATM 11839 O O   . HOH F 2 .   ? 8.825   51.290  3.077   1.00 50.88  ? 616 HOH C O   1 
HETATM 11840 O O   . HOH F 2 .   ? 22.094  53.565  -18.540 1.00 58.97  ? 617 HOH C O   1 
# 
