data_9J9D
# 
_entry.id   9J9D 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9J9D         pdb_00009j9d 10.2210/pdb9j9d/pdb 
WWPDB D_1300050635 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-04-02 ? 
2 'Structure model' 1 1 2025-04-23 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation_author.identifier_ORCID' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9J9D 
_pdbx_database_status.recvd_initial_deposition_date   2024-08-22 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              masaaki.sawa@dd.carnabio.com 
_pdbx_contact_author.name_first         Masaaki 
_pdbx_contact_author.name_last          Sawa 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-0077-2188 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Arai, M.'      1 ? 
'Hanada, M.'    2 ? 
'Taniguchi, H.' 3 ? 
'Ohmoto, H.'    4 ? 
'Naka, K.'      5 ? 
'Sawa, M.'      6 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            J.Med.Chem. 
_citation.journal_id_ASTM           JMCMAR 
_citation.journal_id_CSD            0151 
_citation.journal_id_ISSN           0022-2623 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            68 
_citation.language                  ? 
_citation.page_first                7106 
_citation.page_last                 7118 
_citation.title                     
'Discovery of HM-279, a Potent Inhibitor of ALK5 for Improving Therapeutic Efficacy of Cancer Immunotherapy.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/acs.jmedchem.4c02293 
_citation.pdbx_database_id_PubMed   40108955 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Arai, M.'      1 ? 
primary 'Hanada, M.'    2 ? 
primary 'Taniguchi, H.' 3 ? 
primary 'Nakajima, F.'  4 ? 
primary 'Ohmoto, H.'    5 ? 
primary 'Inoue, T.'     6 ? 
primary 'Naka, K.'      7 ? 
primary 'Sawa, M.'      8 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'TGF-beta receptor type-1' 34953.223 1   2.7.11.30 ? ? ? 
2 non-polymer syn 
'2-((1-(but-2-yn-1-yl)-1H-pyrazol-4-yl)(cyclopropylmethyl)amino)-5-(4-(dimethylcarbamoyl)-1H-pyrrol-2-yl)thiazole-4-carboxamide' 
451.545   1   ?         ? ? ? 
3 non-polymer syn 1,2-ETHANEDIOL 62.068    4   ?         ? ? ? 
4 water       nat water 18.015    225 ?         ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        
;TGFR-1,Activin A receptor type II-like protein kinase of 53kD,Activin receptor-like kinase 5,ALK-5,ALK5,Serine/threonine-protein kinase receptor R4,SKR4,TGF-beta type I receptor,Transforming growth factor-beta receptor type I,TGF-beta receptor type I,TbetaR-I
;
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GATIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLW
LVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVR
HDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPS
VEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GATIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLW
LVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVR
HDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPS
VEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 '2-((1-(but-2-yn-1-yl)-1H-pyrazol-4-yl)(cyclopropylmethyl)amino)-5-(4-(dimethylcarbamoyl)-1H-pyrrol-2-yl)thiazole-4-carboxamide' 
A1L30 
3 1,2-ETHANEDIOL                                                                                                                   
EDO   
4 water                                                                                                                            
HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   ALA n 
1 3   THR n 
1 4   ILE n 
1 5   ALA n 
1 6   ARG n 
1 7   THR n 
1 8   ILE n 
1 9   VAL n 
1 10  LEU n 
1 11  GLN n 
1 12  GLU n 
1 13  SER n 
1 14  ILE n 
1 15  GLY n 
1 16  LYS n 
1 17  GLY n 
1 18  ARG n 
1 19  PHE n 
1 20  GLY n 
1 21  GLU n 
1 22  VAL n 
1 23  TRP n 
1 24  ARG n 
1 25  GLY n 
1 26  LYS n 
1 27  TRP n 
1 28  ARG n 
1 29  GLY n 
1 30  GLU n 
1 31  GLU n 
1 32  VAL n 
1 33  ALA n 
1 34  VAL n 
1 35  LYS n 
1 36  ILE n 
1 37  PHE n 
1 38  SER n 
1 39  SER n 
1 40  ARG n 
1 41  GLU n 
1 42  GLU n 
1 43  ARG n 
1 44  SER n 
1 45  TRP n 
1 46  PHE n 
1 47  ARG n 
1 48  GLU n 
1 49  ALA n 
1 50  GLU n 
1 51  ILE n 
1 52  TYR n 
1 53  GLN n 
1 54  THR n 
1 55  VAL n 
1 56  MET n 
1 57  LEU n 
1 58  ARG n 
1 59  HIS n 
1 60  GLU n 
1 61  ASN n 
1 62  ILE n 
1 63  LEU n 
1 64  GLY n 
1 65  PHE n 
1 66  ILE n 
1 67  ALA n 
1 68  ALA n 
1 69  ASP n 
1 70  ASN n 
1 71  LYS n 
1 72  ASP n 
1 73  ASN n 
1 74  GLY n 
1 75  THR n 
1 76  TRP n 
1 77  THR n 
1 78  GLN n 
1 79  LEU n 
1 80  TRP n 
1 81  LEU n 
1 82  VAL n 
1 83  SER n 
1 84  ASP n 
1 85  TYR n 
1 86  HIS n 
1 87  GLU n 
1 88  HIS n 
1 89  GLY n 
1 90  SER n 
1 91  LEU n 
1 92  PHE n 
1 93  ASP n 
1 94  TYR n 
1 95  LEU n 
1 96  ASN n 
1 97  ARG n 
1 98  TYR n 
1 99  THR n 
1 100 VAL n 
1 101 THR n 
1 102 VAL n 
1 103 GLU n 
1 104 GLY n 
1 105 MET n 
1 106 ILE n 
1 107 LYS n 
1 108 LEU n 
1 109 ALA n 
1 110 LEU n 
1 111 SER n 
1 112 THR n 
1 113 ALA n 
1 114 SER n 
1 115 GLY n 
1 116 LEU n 
1 117 ALA n 
1 118 HIS n 
1 119 LEU n 
1 120 HIS n 
1 121 MET n 
1 122 GLU n 
1 123 ILE n 
1 124 VAL n 
1 125 GLY n 
1 126 THR n 
1 127 GLN n 
1 128 GLY n 
1 129 LYS n 
1 130 PRO n 
1 131 ALA n 
1 132 ILE n 
1 133 ALA n 
1 134 HIS n 
1 135 ARG n 
1 136 ASP n 
1 137 LEU n 
1 138 LYS n 
1 139 SER n 
1 140 LYS n 
1 141 ASN n 
1 142 ILE n 
1 143 LEU n 
1 144 VAL n 
1 145 LYS n 
1 146 LYS n 
1 147 ASN n 
1 148 GLY n 
1 149 THR n 
1 150 CYS n 
1 151 CYS n 
1 152 ILE n 
1 153 ALA n 
1 154 ASP n 
1 155 LEU n 
1 156 GLY n 
1 157 LEU n 
1 158 ALA n 
1 159 VAL n 
1 160 ARG n 
1 161 HIS n 
1 162 ASP n 
1 163 SER n 
1 164 ALA n 
1 165 THR n 
1 166 ASP n 
1 167 THR n 
1 168 ILE n 
1 169 ASP n 
1 170 ILE n 
1 171 ALA n 
1 172 PRO n 
1 173 ASN n 
1 174 HIS n 
1 175 ARG n 
1 176 VAL n 
1 177 GLY n 
1 178 THR n 
1 179 LYS n 
1 180 ARG n 
1 181 TYR n 
1 182 MET n 
1 183 ALA n 
1 184 PRO n 
1 185 GLU n 
1 186 VAL n 
1 187 LEU n 
1 188 ASP n 
1 189 ASP n 
1 190 SER n 
1 191 ILE n 
1 192 ASN n 
1 193 MET n 
1 194 LYS n 
1 195 HIS n 
1 196 PHE n 
1 197 GLU n 
1 198 SER n 
1 199 PHE n 
1 200 LYS n 
1 201 ARG n 
1 202 ALA n 
1 203 ASP n 
1 204 ILE n 
1 205 TYR n 
1 206 ALA n 
1 207 MET n 
1 208 GLY n 
1 209 LEU n 
1 210 VAL n 
1 211 PHE n 
1 212 TRP n 
1 213 GLU n 
1 214 ILE n 
1 215 ALA n 
1 216 ARG n 
1 217 ARG n 
1 218 CYS n 
1 219 SER n 
1 220 ILE n 
1 221 GLY n 
1 222 GLY n 
1 223 ILE n 
1 224 HIS n 
1 225 GLU n 
1 226 ASP n 
1 227 TYR n 
1 228 GLN n 
1 229 LEU n 
1 230 PRO n 
1 231 TYR n 
1 232 TYR n 
1 233 ASP n 
1 234 LEU n 
1 235 VAL n 
1 236 PRO n 
1 237 SER n 
1 238 ASP n 
1 239 PRO n 
1 240 SER n 
1 241 VAL n 
1 242 GLU n 
1 243 GLU n 
1 244 MET n 
1 245 ARG n 
1 246 LYS n 
1 247 VAL n 
1 248 VAL n 
1 249 CYS n 
1 250 GLU n 
1 251 GLN n 
1 252 LYS n 
1 253 LEU n 
1 254 ARG n 
1 255 PRO n 
1 256 ASN n 
1 257 ILE n 
1 258 PRO n 
1 259 ASN n 
1 260 ARG n 
1 261 TRP n 
1 262 GLN n 
1 263 SER n 
1 264 CYS n 
1 265 GLU n 
1 266 ALA n 
1 267 LEU n 
1 268 ARG n 
1 269 VAL n 
1 270 MET n 
1 271 ALA n 
1 272 LYS n 
1 273 ILE n 
1 274 MET n 
1 275 ARG n 
1 276 GLU n 
1 277 CYS n 
1 278 TRP n 
1 279 TYR n 
1 280 ALA n 
1 281 ASN n 
1 282 GLY n 
1 283 ALA n 
1 284 ALA n 
1 285 ARG n 
1 286 LEU n 
1 287 THR n 
1 288 ALA n 
1 289 LEU n 
1 290 ARG n 
1 291 ILE n 
1 292 LYS n 
1 293 LYS n 
1 294 THR n 
1 295 LEU n 
1 296 SER n 
1 297 GLN n 
1 298 LEU n 
1 299 SER n 
1 300 GLN n 
1 301 GLN n 
1 302 GLU n 
1 303 GLY n 
1 304 ILE n 
1 305 LYS n 
1 306 MET n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   306 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'TGFBR1, ALK5, SKR4' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Spodoptera frugiperda' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     7108 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1L30 non-polymer         . 
'2-((1-(but-2-yn-1-yl)-1H-pyrazol-4-yl)(cyclopropylmethyl)amino)-5-(4-(dimethylcarbamoyl)-1H-pyrrol-2-yl)thiazole-4-carboxamide' ? 
'C22 H25 N7 O2 S' 451.545 
ALA   'L-peptide linking' y ALANINE ?                 'C3 H7 N O2'      89.093  
ARG   'L-peptide linking' y ARGININE ?                 'C6 H15 N4 O2 1'  175.209 
ASN   'L-peptide linking' y ASPARAGINE ?                 'C4 H8 N2 O3'     132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID' ?                 'C4 H7 N O4'      133.103 
CYS   'L-peptide linking' y CYSTEINE ?                 'C3 H7 N O2 S'    121.158 
EDO   non-polymer         . 1,2-ETHANEDIOL 'ETHYLENE GLYCOL' 'C2 H6 O2'        62.068  
GLN   'L-peptide linking' y GLUTAMINE ?                 'C5 H10 N2 O3'    146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID' ?                 'C5 H9 N O4'      147.129 
GLY   'peptide linking'   y GLYCINE ?                 'C2 H5 N O2'      75.067  
HIS   'L-peptide linking' y HISTIDINE ?                 'C6 H10 N3 O2 1'  156.162 
HOH   non-polymer         . WATER ?                 'H2 O'            18.015  
ILE   'L-peptide linking' y ISOLEUCINE ?                 'C6 H13 N O2'     131.173 
LEU   'L-peptide linking' y LEUCINE ?                 'C6 H13 N O2'     131.173 
LYS   'L-peptide linking' y LYSINE ?                 'C6 H15 N2 O2 1'  147.195 
MET   'L-peptide linking' y METHIONINE ?                 'C5 H11 N O2 S'   149.211 
PHE   'L-peptide linking' y PHENYLALANINE ?                 'C9 H11 N O2'     165.189 
PRO   'L-peptide linking' y PROLINE ?                 'C5 H9 N O2'      115.130 
SER   'L-peptide linking' y SERINE ?                 'C3 H7 N O3'      105.093 
THR   'L-peptide linking' y THREONINE ?                 'C4 H9 N O3'      119.119 
TRP   'L-peptide linking' y TRYPTOPHAN ?                 'C11 H12 N2 O2'   204.225 
TYR   'L-peptide linking' y TYROSINE ?                 'C9 H11 N O3'     181.189 
VAL   'L-peptide linking' y VALINE ?                 'C5 H11 N O2'     117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   198 ?   ?   ?   A . n 
A 1 2   ALA 2   199 ?   ?   ?   A . n 
A 1 3   THR 3   200 ?   ?   ?   A . n 
A 1 4   ILE 4   201 ?   ?   ?   A . n 
A 1 5   ALA 5   202 202 ALA ALA A . n 
A 1 6   ARG 6   203 203 ARG ARG A . n 
A 1 7   THR 7   204 204 THR THR A . n 
A 1 8   ILE 8   205 205 ILE ILE A . n 
A 1 9   VAL 9   206 206 VAL VAL A . n 
A 1 10  LEU 10  207 207 LEU LEU A . n 
A 1 11  GLN 11  208 208 GLN GLN A . n 
A 1 12  GLU 12  209 209 GLU GLU A . n 
A 1 13  SER 13  210 210 SER SER A . n 
A 1 14  ILE 14  211 211 ILE ILE A . n 
A 1 15  GLY 15  212 212 GLY GLY A . n 
A 1 16  LYS 16  213 ?   ?   ?   A . n 
A 1 17  GLY 17  214 ?   ?   ?   A . n 
A 1 18  ARG 18  215 ?   ?   ?   A . n 
A 1 19  PHE 19  216 216 PHE PHE A . n 
A 1 20  GLY 20  217 217 GLY GLY A . n 
A 1 21  GLU 21  218 218 GLU GLU A . n 
A 1 22  VAL 22  219 219 VAL VAL A . n 
A 1 23  TRP 23  220 220 TRP TRP A . n 
A 1 24  ARG 24  221 221 ARG ARG A . n 
A 1 25  GLY 25  222 222 GLY GLY A . n 
A 1 26  LYS 26  223 223 LYS LYS A . n 
A 1 27  TRP 27  224 224 TRP TRP A . n 
A 1 28  ARG 28  225 225 ARG ARG A . n 
A 1 29  GLY 29  226 226 GLY GLY A . n 
A 1 30  GLU 30  227 227 GLU GLU A . n 
A 1 31  GLU 31  228 228 GLU GLU A . n 
A 1 32  VAL 32  229 229 VAL VAL A . n 
A 1 33  ALA 33  230 230 ALA ALA A . n 
A 1 34  VAL 34  231 231 VAL VAL A . n 
A 1 35  LYS 35  232 232 LYS LYS A . n 
A 1 36  ILE 36  233 233 ILE ILE A . n 
A 1 37  PHE 37  234 234 PHE PHE A . n 
A 1 38  SER 38  235 235 SER SER A . n 
A 1 39  SER 39  236 236 SER SER A . n 
A 1 40  ARG 40  237 237 ARG ARG A . n 
A 1 41  GLU 41  238 238 GLU GLU A . n 
A 1 42  GLU 42  239 239 GLU GLU A . n 
A 1 43  ARG 43  240 240 ARG ARG A . n 
A 1 44  SER 44  241 241 SER SER A . n 
A 1 45  TRP 45  242 242 TRP TRP A . n 
A 1 46  PHE 46  243 243 PHE PHE A . n 
A 1 47  ARG 47  244 244 ARG ARG A . n 
A 1 48  GLU 48  245 245 GLU GLU A . n 
A 1 49  ALA 49  246 246 ALA ALA A . n 
A 1 50  GLU 50  247 247 GLU GLU A . n 
A 1 51  ILE 51  248 248 ILE ILE A . n 
A 1 52  TYR 52  249 249 TYR TYR A . n 
A 1 53  GLN 53  250 250 GLN GLN A . n 
A 1 54  THR 54  251 251 THR THR A . n 
A 1 55  VAL 55  252 252 VAL VAL A . n 
A 1 56  MET 56  253 253 MET MET A . n 
A 1 57  LEU 57  254 254 LEU LEU A . n 
A 1 58  ARG 58  255 255 ARG ARG A . n 
A 1 59  HIS 59  256 256 HIS HIS A . n 
A 1 60  GLU 60  257 257 GLU GLU A . n 
A 1 61  ASN 61  258 258 ASN ASN A . n 
A 1 62  ILE 62  259 259 ILE ILE A . n 
A 1 63  LEU 63  260 260 LEU LEU A . n 
A 1 64  GLY 64  261 261 GLY GLY A . n 
A 1 65  PHE 65  262 262 PHE PHE A . n 
A 1 66  ILE 66  263 263 ILE ILE A . n 
A 1 67  ALA 67  264 264 ALA ALA A . n 
A 1 68  ALA 68  265 265 ALA ALA A . n 
A 1 69  ASP 69  266 266 ASP ASP A . n 
A 1 70  ASN 70  267 267 ASN ASN A . n 
A 1 71  LYS 71  268 268 LYS LYS A . n 
A 1 72  ASP 72  269 269 ASP ASP A . n 
A 1 73  ASN 73  270 270 ASN ASN A . n 
A 1 74  GLY 74  271 271 GLY GLY A . n 
A 1 75  THR 75  272 272 THR THR A . n 
A 1 76  TRP 76  273 273 TRP TRP A . n 
A 1 77  THR 77  274 274 THR THR A . n 
A 1 78  GLN 78  275 275 GLN GLN A . n 
A 1 79  LEU 79  276 276 LEU LEU A . n 
A 1 80  TRP 80  277 277 TRP TRP A . n 
A 1 81  LEU 81  278 278 LEU LEU A . n 
A 1 82  VAL 82  279 279 VAL VAL A . n 
A 1 83  SER 83  280 280 SER SER A . n 
A 1 84  ASP 84  281 281 ASP ASP A . n 
A 1 85  TYR 85  282 282 TYR TYR A . n 
A 1 86  HIS 86  283 283 HIS HIS A . n 
A 1 87  GLU 87  284 284 GLU GLU A . n 
A 1 88  HIS 88  285 285 HIS HIS A . n 
A 1 89  GLY 89  286 286 GLY GLY A . n 
A 1 90  SER 90  287 287 SER SER A . n 
A 1 91  LEU 91  288 288 LEU LEU A . n 
A 1 92  PHE 92  289 289 PHE PHE A . n 
A 1 93  ASP 93  290 290 ASP ASP A . n 
A 1 94  TYR 94  291 291 TYR TYR A . n 
A 1 95  LEU 95  292 292 LEU LEU A . n 
A 1 96  ASN 96  293 293 ASN ASN A . n 
A 1 97  ARG 97  294 294 ARG ARG A . n 
A 1 98  TYR 98  295 295 TYR TYR A . n 
A 1 99  THR 99  296 296 THR THR A . n 
A 1 100 VAL 100 297 297 VAL VAL A . n 
A 1 101 THR 101 298 298 THR THR A . n 
A 1 102 VAL 102 299 299 VAL VAL A . n 
A 1 103 GLU 103 300 300 GLU GLU A . n 
A 1 104 GLY 104 301 301 GLY GLY A . n 
A 1 105 MET 105 302 302 MET MET A . n 
A 1 106 ILE 106 303 303 ILE ILE A . n 
A 1 107 LYS 107 304 304 LYS LYS A . n 
A 1 108 LEU 108 305 305 LEU LEU A . n 
A 1 109 ALA 109 306 306 ALA ALA A . n 
A 1 110 LEU 110 307 307 LEU LEU A . n 
A 1 111 SER 111 308 308 SER SER A . n 
A 1 112 THR 112 309 309 THR THR A . n 
A 1 113 ALA 113 310 310 ALA ALA A . n 
A 1 114 SER 114 311 311 SER SER A . n 
A 1 115 GLY 115 312 312 GLY GLY A . n 
A 1 116 LEU 116 313 313 LEU LEU A . n 
A 1 117 ALA 117 314 314 ALA ALA A . n 
A 1 118 HIS 118 315 315 HIS HIS A . n 
A 1 119 LEU 119 316 316 LEU LEU A . n 
A 1 120 HIS 120 317 317 HIS HIS A . n 
A 1 121 MET 121 318 318 MET MET A . n 
A 1 122 GLU 122 319 319 GLU GLU A . n 
A 1 123 ILE 123 320 320 ILE ILE A . n 
A 1 124 VAL 124 321 321 VAL VAL A . n 
A 1 125 GLY 125 322 322 GLY GLY A . n 
A 1 126 THR 126 323 323 THR THR A . n 
A 1 127 GLN 127 324 324 GLN GLN A . n 
A 1 128 GLY 128 325 325 GLY GLY A . n 
A 1 129 LYS 129 326 326 LYS LYS A . n 
A 1 130 PRO 130 327 327 PRO PRO A . n 
A 1 131 ALA 131 328 328 ALA ALA A . n 
A 1 132 ILE 132 329 329 ILE ILE A . n 
A 1 133 ALA 133 330 330 ALA ALA A . n 
A 1 134 HIS 134 331 331 HIS HIS A . n 
A 1 135 ARG 135 332 332 ARG ARG A . n 
A 1 136 ASP 136 333 333 ASP ASP A . n 
A 1 137 LEU 137 334 334 LEU LEU A . n 
A 1 138 LYS 138 335 335 LYS LYS A . n 
A 1 139 SER 139 336 336 SER SER A . n 
A 1 140 LYS 140 337 337 LYS LYS A . n 
A 1 141 ASN 141 338 338 ASN ASN A . n 
A 1 142 ILE 142 339 339 ILE ILE A . n 
A 1 143 LEU 143 340 340 LEU LEU A . n 
A 1 144 VAL 144 341 341 VAL VAL A . n 
A 1 145 LYS 145 342 342 LYS LYS A . n 
A 1 146 LYS 146 343 343 LYS LYS A . n 
A 1 147 ASN 147 344 344 ASN ASN A . n 
A 1 148 GLY 148 345 345 GLY GLY A . n 
A 1 149 THR 149 346 346 THR THR A . n 
A 1 150 CYS 150 347 347 CYS CYS A . n 
A 1 151 CYS 151 348 348 CYS CYS A . n 
A 1 152 ILE 152 349 349 ILE ILE A . n 
A 1 153 ALA 153 350 350 ALA ALA A . n 
A 1 154 ASP 154 351 351 ASP ASP A . n 
A 1 155 LEU 155 352 352 LEU LEU A . n 
A 1 156 GLY 156 353 353 GLY GLY A . n 
A 1 157 LEU 157 354 354 LEU LEU A . n 
A 1 158 ALA 158 355 355 ALA ALA A . n 
A 1 159 VAL 159 356 356 VAL VAL A . n 
A 1 160 ARG 160 357 357 ARG ARG A . n 
A 1 161 HIS 161 358 358 HIS HIS A . n 
A 1 162 ASP 162 359 359 ASP ASP A . n 
A 1 163 SER 163 360 360 SER SER A . n 
A 1 164 ALA 164 361 361 ALA ALA A . n 
A 1 165 THR 165 362 362 THR THR A . n 
A 1 166 ASP 166 363 363 ASP ASP A . n 
A 1 167 THR 167 364 364 THR THR A . n 
A 1 168 ILE 168 365 365 ILE ILE A . n 
A 1 169 ASP 169 366 366 ASP ASP A . n 
A 1 170 ILE 170 367 367 ILE ILE A . n 
A 1 171 ALA 171 368 368 ALA ALA A . n 
A 1 172 PRO 172 369 369 PRO PRO A . n 
A 1 173 ASN 173 370 ?   ?   ?   A . n 
A 1 174 HIS 174 371 ?   ?   ?   A . n 
A 1 175 ARG 175 372 372 ARG ARG A . n 
A 1 176 VAL 176 373 373 VAL VAL A . n 
A 1 177 GLY 177 374 374 GLY GLY A . n 
A 1 178 THR 178 375 375 THR THR A . n 
A 1 179 LYS 179 376 376 LYS LYS A . n 
A 1 180 ARG 180 377 377 ARG ARG A . n 
A 1 181 TYR 181 378 378 TYR TYR A . n 
A 1 182 MET 182 379 379 MET MET A . n 
A 1 183 ALA 183 380 380 ALA ALA A . n 
A 1 184 PRO 184 381 381 PRO PRO A . n 
A 1 185 GLU 185 382 382 GLU GLU A . n 
A 1 186 VAL 186 383 383 VAL VAL A . n 
A 1 187 LEU 187 384 384 LEU LEU A . n 
A 1 188 ASP 188 385 385 ASP ASP A . n 
A 1 189 ASP 189 386 386 ASP ASP A . n 
A 1 190 SER 190 387 387 SER SER A . n 
A 1 191 ILE 191 388 388 ILE ILE A . n 
A 1 192 ASN 192 389 389 ASN ASN A . n 
A 1 193 MET 193 390 390 MET MET A . n 
A 1 194 LYS 194 391 391 LYS LYS A . n 
A 1 195 HIS 195 392 392 HIS HIS A . n 
A 1 196 PHE 196 393 393 PHE PHE A . n 
A 1 197 GLU 197 394 394 GLU GLU A . n 
A 1 198 SER 198 395 395 SER SER A . n 
A 1 199 PHE 199 396 396 PHE PHE A . n 
A 1 200 LYS 200 397 397 LYS LYS A . n 
A 1 201 ARG 201 398 398 ARG ARG A . n 
A 1 202 ALA 202 399 399 ALA ALA A . n 
A 1 203 ASP 203 400 400 ASP ASP A . n 
A 1 204 ILE 204 401 401 ILE ILE A . n 
A 1 205 TYR 205 402 402 TYR TYR A . n 
A 1 206 ALA 206 403 403 ALA ALA A . n 
A 1 207 MET 207 404 404 MET MET A . n 
A 1 208 GLY 208 405 405 GLY GLY A . n 
A 1 209 LEU 209 406 406 LEU LEU A . n 
A 1 210 VAL 210 407 407 VAL VAL A . n 
A 1 211 PHE 211 408 408 PHE PHE A . n 
A 1 212 TRP 212 409 409 TRP TRP A . n 
A 1 213 GLU 213 410 410 GLU GLU A . n 
A 1 214 ILE 214 411 411 ILE ILE A . n 
A 1 215 ALA 215 412 412 ALA ALA A . n 
A 1 216 ARG 216 413 413 ARG ARG A . n 
A 1 217 ARG 217 414 414 ARG ARG A . n 
A 1 218 CYS 218 415 415 CYS CYS A . n 
A 1 219 SER 219 416 416 SER SER A . n 
A 1 220 ILE 220 417 417 ILE ILE A . n 
A 1 221 GLY 221 418 418 GLY GLY A . n 
A 1 222 GLY 222 419 419 GLY GLY A . n 
A 1 223 ILE 223 420 420 ILE ILE A . n 
A 1 224 HIS 224 421 421 HIS HIS A . n 
A 1 225 GLU 225 422 422 GLU GLU A . n 
A 1 226 ASP 226 423 423 ASP ASP A . n 
A 1 227 TYR 227 424 424 TYR TYR A . n 
A 1 228 GLN 228 425 425 GLN GLN A . n 
A 1 229 LEU 229 426 426 LEU LEU A . n 
A 1 230 PRO 230 427 427 PRO PRO A . n 
A 1 231 TYR 231 428 428 TYR TYR A . n 
A 1 232 TYR 232 429 429 TYR TYR A . n 
A 1 233 ASP 233 430 430 ASP ASP A . n 
A 1 234 LEU 234 431 431 LEU LEU A . n 
A 1 235 VAL 235 432 432 VAL VAL A . n 
A 1 236 PRO 236 433 433 PRO PRO A . n 
A 1 237 SER 237 434 434 SER SER A . n 
A 1 238 ASP 238 435 435 ASP ASP A . n 
A 1 239 PRO 239 436 436 PRO PRO A . n 
A 1 240 SER 240 437 437 SER SER A . n 
A 1 241 VAL 241 438 438 VAL VAL A . n 
A 1 242 GLU 242 439 439 GLU GLU A . n 
A 1 243 GLU 243 440 440 GLU GLU A . n 
A 1 244 MET 244 441 441 MET MET A . n 
A 1 245 ARG 245 442 442 ARG ARG A . n 
A 1 246 LYS 246 443 443 LYS LYS A . n 
A 1 247 VAL 247 444 444 VAL VAL A . n 
A 1 248 VAL 248 445 445 VAL VAL A . n 
A 1 249 CYS 249 446 446 CYS CYS A . n 
A 1 250 GLU 250 447 447 GLU GLU A . n 
A 1 251 GLN 251 448 448 GLN GLN A . n 
A 1 252 LYS 252 449 449 LYS LYS A . n 
A 1 253 LEU 253 450 450 LEU LEU A . n 
A 1 254 ARG 254 451 451 ARG ARG A . n 
A 1 255 PRO 255 452 452 PRO PRO A . n 
A 1 256 ASN 256 453 453 ASN ASN A . n 
A 1 257 ILE 257 454 454 ILE ILE A . n 
A 1 258 PRO 258 455 455 PRO PRO A . n 
A 1 259 ASN 259 456 456 ASN ASN A . n 
A 1 260 ARG 260 457 457 ARG ARG A . n 
A 1 261 TRP 261 458 458 TRP TRP A . n 
A 1 262 GLN 262 459 459 GLN GLN A . n 
A 1 263 SER 263 460 460 SER SER A . n 
A 1 264 CYS 264 461 461 CYS CYS A . n 
A 1 265 GLU 265 462 462 GLU GLU A . n 
A 1 266 ALA 266 463 463 ALA ALA A . n 
A 1 267 LEU 267 464 464 LEU LEU A . n 
A 1 268 ARG 268 465 465 ARG ARG A . n 
A 1 269 VAL 269 466 466 VAL VAL A . n 
A 1 270 MET 270 467 467 MET MET A . n 
A 1 271 ALA 271 468 468 ALA ALA A . n 
A 1 272 LYS 272 469 469 LYS LYS A . n 
A 1 273 ILE 273 470 470 ILE ILE A . n 
A 1 274 MET 274 471 471 MET MET A . n 
A 1 275 ARG 275 472 472 ARG ARG A . n 
A 1 276 GLU 276 473 473 GLU GLU A . n 
A 1 277 CYS 277 474 474 CYS CYS A . n 
A 1 278 TRP 278 475 475 TRP TRP A . n 
A 1 279 TYR 279 476 476 TYR TYR A . n 
A 1 280 ALA 280 477 477 ALA ALA A . n 
A 1 281 ASN 281 478 478 ASN ASN A . n 
A 1 282 GLY 282 479 479 GLY GLY A . n 
A 1 283 ALA 283 480 480 ALA ALA A . n 
A 1 284 ALA 284 481 481 ALA ALA A . n 
A 1 285 ARG 285 482 482 ARG ARG A . n 
A 1 286 LEU 286 483 483 LEU LEU A . n 
A 1 287 THR 287 484 484 THR THR A . n 
A 1 288 ALA 288 485 485 ALA ALA A . n 
A 1 289 LEU 289 486 486 LEU LEU A . n 
A 1 290 ARG 290 487 487 ARG ARG A . n 
A 1 291 ILE 291 488 488 ILE ILE A . n 
A 1 292 LYS 292 489 489 LYS LYS A . n 
A 1 293 LYS 293 490 490 LYS LYS A . n 
A 1 294 THR 294 491 491 THR THR A . n 
A 1 295 LEU 295 492 492 LEU LEU A . n 
A 1 296 SER 296 493 493 SER SER A . n 
A 1 297 GLN 297 494 494 GLN GLN A . n 
A 1 298 LEU 298 495 495 LEU LEU A . n 
A 1 299 SER 299 496 496 SER SER A . n 
A 1 300 GLN 300 497 497 GLN GLN A . n 
A 1 301 GLN 301 498 498 GLN GLN A . n 
A 1 302 GLU 302 499 499 GLU GLU A . n 
A 1 303 GLY 303 500 500 GLY GLY A . n 
A 1 304 ILE 304 501 501 ILE ILE A . n 
A 1 305 LYS 305 502 502 LYS LYS A . n 
A 1 306 MET 306 503 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1L30 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1L30 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 A1L30 1   701  701 A1L30 279 A . 
C 3 EDO   1   702  1   EDO   EDO A . 
D 3 EDO   1   703  2   EDO   EDO A . 
E 3 EDO   1   704  3   EDO   EDO A . 
F 3 EDO   1   705  4   EDO   EDO A . 
G 4 HOH   1   801  117 HOH   HOH A . 
G 4 HOH   2   802  210 HOH   HOH A . 
G 4 HOH   3   803  212 HOH   HOH A . 
G 4 HOH   4   804  128 HOH   HOH A . 
G 4 HOH   5   805  172 HOH   HOH A . 
G 4 HOH   6   806  115 HOH   HOH A . 
G 4 HOH   7   807  107 HOH   HOH A . 
G 4 HOH   8   808  104 HOH   HOH A . 
G 4 HOH   9   809  187 HOH   HOH A . 
G 4 HOH   10  810  164 HOH   HOH A . 
G 4 HOH   11  811  23  HOH   HOH A . 
G 4 HOH   12  812  17  HOH   HOH A . 
G 4 HOH   13  813  38  HOH   HOH A . 
G 4 HOH   14  814  158 HOH   HOH A . 
G 4 HOH   15  815  146 HOH   HOH A . 
G 4 HOH   16  816  149 HOH   HOH A . 
G 4 HOH   17  817  218 HOH   HOH A . 
G 4 HOH   18  818  63  HOH   HOH A . 
G 4 HOH   19  819  144 HOH   HOH A . 
G 4 HOH   20  820  125 HOH   HOH A . 
G 4 HOH   21  821  75  HOH   HOH A . 
G 4 HOH   22  822  121 HOH   HOH A . 
G 4 HOH   23  823  124 HOH   HOH A . 
G 4 HOH   24  824  35  HOH   HOH A . 
G 4 HOH   25  825  112 HOH   HOH A . 
G 4 HOH   26  826  58  HOH   HOH A . 
G 4 HOH   27  827  8   HOH   HOH A . 
G 4 HOH   28  828  197 HOH   HOH A . 
G 4 HOH   29  829  21  HOH   HOH A . 
G 4 HOH   30  830  78  HOH   HOH A . 
G 4 HOH   31  831  183 HOH   HOH A . 
G 4 HOH   32  832  225 HOH   HOH A . 
G 4 HOH   33  833  132 HOH   HOH A . 
G 4 HOH   34  834  145 HOH   HOH A . 
G 4 HOH   35  835  219 HOH   HOH A . 
G 4 HOH   36  836  153 HOH   HOH A . 
G 4 HOH   37  837  143 HOH   HOH A . 
G 4 HOH   38  838  205 HOH   HOH A . 
G 4 HOH   39  839  99  HOH   HOH A . 
G 4 HOH   40  840  68  HOH   HOH A . 
G 4 HOH   41  841  76  HOH   HOH A . 
G 4 HOH   42  842  201 HOH   HOH A . 
G 4 HOH   43  843  50  HOH   HOH A . 
G 4 HOH   44  844  122 HOH   HOH A . 
G 4 HOH   45  845  155 HOH   HOH A . 
G 4 HOH   46  846  116 HOH   HOH A . 
G 4 HOH   47  847  202 HOH   HOH A . 
G 4 HOH   48  848  56  HOH   HOH A . 
G 4 HOH   49  849  203 HOH   HOH A . 
G 4 HOH   50  850  4   HOH   HOH A . 
G 4 HOH   51  851  142 HOH   HOH A . 
G 4 HOH   52  852  160 HOH   HOH A . 
G 4 HOH   53  853  151 HOH   HOH A . 
G 4 HOH   54  854  93  HOH   HOH A . 
G 4 HOH   55  855  72  HOH   HOH A . 
G 4 HOH   56  856  25  HOH   HOH A . 
G 4 HOH   57  857  40  HOH   HOH A . 
G 4 HOH   58  858  150 HOH   HOH A . 
G 4 HOH   59  859  169 HOH   HOH A . 
G 4 HOH   60  860  108 HOH   HOH A . 
G 4 HOH   61  861  71  HOH   HOH A . 
G 4 HOH   62  862  84  HOH   HOH A . 
G 4 HOH   63  863  214 HOH   HOH A . 
G 4 HOH   64  864  133 HOH   HOH A . 
G 4 HOH   65  865  215 HOH   HOH A . 
G 4 HOH   66  866  36  HOH   HOH A . 
G 4 HOH   67  867  24  HOH   HOH A . 
G 4 HOH   68  868  60  HOH   HOH A . 
G 4 HOH   69  869  87  HOH   HOH A . 
G 4 HOH   70  870  98  HOH   HOH A . 
G 4 HOH   71  871  204 HOH   HOH A . 
G 4 HOH   72  872  129 HOH   HOH A . 
G 4 HOH   73  873  97  HOH   HOH A . 
G 4 HOH   74  874  47  HOH   HOH A . 
G 4 HOH   75  875  22  HOH   HOH A . 
G 4 HOH   76  876  200 HOH   HOH A . 
G 4 HOH   77  877  59  HOH   HOH A . 
G 4 HOH   78  878  114 HOH   HOH A . 
G 4 HOH   79  879  154 HOH   HOH A . 
G 4 HOH   80  880  55  HOH   HOH A . 
G 4 HOH   81  881  44  HOH   HOH A . 
G 4 HOH   82  882  193 HOH   HOH A . 
G 4 HOH   83  883  180 HOH   HOH A . 
G 4 HOH   84  884  106 HOH   HOH A . 
G 4 HOH   85  885  113 HOH   HOH A . 
G 4 HOH   86  886  28  HOH   HOH A . 
G 4 HOH   87  887  51  HOH   HOH A . 
G 4 HOH   88  888  109 HOH   HOH A . 
G 4 HOH   89  889  91  HOH   HOH A . 
G 4 HOH   90  890  11  HOH   HOH A . 
G 4 HOH   91  891  53  HOH   HOH A . 
G 4 HOH   92  892  163 HOH   HOH A . 
G 4 HOH   93  893  83  HOH   HOH A . 
G 4 HOH   94  894  126 HOH   HOH A . 
G 4 HOH   95  895  184 HOH   HOH A . 
G 4 HOH   96  896  127 HOH   HOH A . 
G 4 HOH   97  897  148 HOH   HOH A . 
G 4 HOH   98  898  171 HOH   HOH A . 
G 4 HOH   99  899  206 HOH   HOH A . 
G 4 HOH   100 900  27  HOH   HOH A . 
G 4 HOH   101 901  5   HOH   HOH A . 
G 4 HOH   102 902  82  HOH   HOH A . 
G 4 HOH   103 903  19  HOH   HOH A . 
G 4 HOH   104 904  177 HOH   HOH A . 
G 4 HOH   105 905  192 HOH   HOH A . 
G 4 HOH   106 906  168 HOH   HOH A . 
G 4 HOH   107 907  95  HOH   HOH A . 
G 4 HOH   108 908  85  HOH   HOH A . 
G 4 HOH   109 909  7   HOH   HOH A . 
G 4 HOH   110 910  196 HOH   HOH A . 
G 4 HOH   111 911  15  HOH   HOH A . 
G 4 HOH   112 912  90  HOH   HOH A . 
G 4 HOH   113 913  14  HOH   HOH A . 
G 4 HOH   114 914  41  HOH   HOH A . 
G 4 HOH   115 915  57  HOH   HOH A . 
G 4 HOH   116 916  61  HOH   HOH A . 
G 4 HOH   117 917  176 HOH   HOH A . 
G 4 HOH   118 918  208 HOH   HOH A . 
G 4 HOH   119 919  2   HOH   HOH A . 
G 4 HOH   120 920  16  HOH   HOH A . 
G 4 HOH   121 921  34  HOH   HOH A . 
G 4 HOH   122 922  6   HOH   HOH A . 
G 4 HOH   123 923  223 HOH   HOH A . 
G 4 HOH   124 924  77  HOH   HOH A . 
G 4 HOH   125 925  73  HOH   HOH A . 
G 4 HOH   126 926  100 HOH   HOH A . 
G 4 HOH   127 927  48  HOH   HOH A . 
G 4 HOH   128 928  29  HOH   HOH A . 
G 4 HOH   129 929  3   HOH   HOH A . 
G 4 HOH   130 930  135 HOH   HOH A . 
G 4 HOH   131 931  26  HOH   HOH A . 
G 4 HOH   132 932  31  HOH   HOH A . 
G 4 HOH   133 933  207 HOH   HOH A . 
G 4 HOH   134 934  195 HOH   HOH A . 
G 4 HOH   135 935  39  HOH   HOH A . 
G 4 HOH   136 936  217 HOH   HOH A . 
G 4 HOH   137 937  123 HOH   HOH A . 
G 4 HOH   138 938  79  HOH   HOH A . 
G 4 HOH   139 939  166 HOH   HOH A . 
G 4 HOH   140 940  138 HOH   HOH A . 
G 4 HOH   141 941  92  HOH   HOH A . 
G 4 HOH   142 942  111 HOH   HOH A . 
G 4 HOH   143 943  191 HOH   HOH A . 
G 4 HOH   144 944  1   HOH   HOH A . 
G 4 HOH   145 945  213 HOH   HOH A . 
G 4 HOH   146 946  102 HOH   HOH A . 
G 4 HOH   147 947  81  HOH   HOH A . 
G 4 HOH   148 948  198 HOH   HOH A . 
G 4 HOH   149 949  178 HOH   HOH A . 
G 4 HOH   150 950  30  HOH   HOH A . 
G 4 HOH   151 951  167 HOH   HOH A . 
G 4 HOH   152 952  159 HOH   HOH A . 
G 4 HOH   153 953  173 HOH   HOH A . 
G 4 HOH   154 954  94  HOH   HOH A . 
G 4 HOH   155 955  118 HOH   HOH A . 
G 4 HOH   156 956  105 HOH   HOH A . 
G 4 HOH   157 957  13  HOH   HOH A . 
G 4 HOH   158 958  20  HOH   HOH A . 
G 4 HOH   159 959  64  HOH   HOH A . 
G 4 HOH   160 960  161 HOH   HOH A . 
G 4 HOH   161 961  186 HOH   HOH A . 
G 4 HOH   162 962  130 HOH   HOH A . 
G 4 HOH   163 963  140 HOH   HOH A . 
G 4 HOH   164 964  131 HOH   HOH A . 
G 4 HOH   165 965  70  HOH   HOH A . 
G 4 HOH   166 966  80  HOH   HOH A . 
G 4 HOH   167 967  52  HOH   HOH A . 
G 4 HOH   168 968  147 HOH   HOH A . 
G 4 HOH   169 969  170 HOH   HOH A . 
G 4 HOH   170 970  67  HOH   HOH A . 
G 4 HOH   171 971  136 HOH   HOH A . 
G 4 HOH   172 972  12  HOH   HOH A . 
G 4 HOH   173 973  10  HOH   HOH A . 
G 4 HOH   174 974  119 HOH   HOH A . 
G 4 HOH   175 975  175 HOH   HOH A . 
G 4 HOH   176 976  194 HOH   HOH A . 
G 4 HOH   177 977  43  HOH   HOH A . 
G 4 HOH   178 978  66  HOH   HOH A . 
G 4 HOH   179 979  18  HOH   HOH A . 
G 4 HOH   180 980  42  HOH   HOH A . 
G 4 HOH   181 981  49  HOH   HOH A . 
G 4 HOH   182 982  179 HOH   HOH A . 
G 4 HOH   183 983  46  HOH   HOH A . 
G 4 HOH   184 984  9   HOH   HOH A . 
G 4 HOH   185 985  199 HOH   HOH A . 
G 4 HOH   186 986  141 HOH   HOH A . 
G 4 HOH   187 987  86  HOH   HOH A . 
G 4 HOH   188 988  89  HOH   HOH A . 
G 4 HOH   189 989  33  HOH   HOH A . 
G 4 HOH   190 990  165 HOH   HOH A . 
G 4 HOH   191 991  162 HOH   HOH A . 
G 4 HOH   192 992  216 HOH   HOH A . 
G 4 HOH   193 993  209 HOH   HOH A . 
G 4 HOH   194 994  120 HOH   HOH A . 
G 4 HOH   195 995  88  HOH   HOH A . 
G 4 HOH   196 996  37  HOH   HOH A . 
G 4 HOH   197 997  45  HOH   HOH A . 
G 4 HOH   198 998  156 HOH   HOH A . 
G 4 HOH   199 999  226 HOH   HOH A . 
G 4 HOH   200 1000 54  HOH   HOH A . 
G 4 HOH   201 1001 65  HOH   HOH A . 
G 4 HOH   202 1002 103 HOH   HOH A . 
G 4 HOH   203 1003 224 HOH   HOH A . 
G 4 HOH   204 1004 189 HOH   HOH A . 
G 4 HOH   205 1005 182 HOH   HOH A . 
G 4 HOH   206 1006 157 HOH   HOH A . 
G 4 HOH   207 1007 139 HOH   HOH A . 
G 4 HOH   208 1008 190 HOH   HOH A . 
G 4 HOH   209 1009 62  HOH   HOH A . 
G 4 HOH   210 1010 152 HOH   HOH A . 
G 4 HOH   211 1011 181 HOH   HOH A . 
G 4 HOH   212 1012 32  HOH   HOH A . 
G 4 HOH   213 1013 101 HOH   HOH A . 
G 4 HOH   214 1014 222 HOH   HOH A . 
G 4 HOH   215 1015 134 HOH   HOH A . 
G 4 HOH   216 1016 137 HOH   HOH A . 
G 4 HOH   217 1017 110 HOH   HOH A . 
G 4 HOH   218 1018 174 HOH   HOH A . 
G 4 HOH   219 1019 221 HOH   HOH A . 
G 4 HOH   220 1020 74  HOH   HOH A . 
G 4 HOH   221 1021 69  HOH   HOH A . 
G 4 HOH   222 1022 188 HOH   HOH A . 
G 4 HOH   223 1023 220 HOH   HOH A . 
G 4 HOH   224 1024 96  HOH   HOH A . 
G 4 HOH   225 1025 185 HOH   HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A ARG 203 ? CG  ? A ARG 6   CG  
2  1 Y 1 A ARG 203 ? CD  ? A ARG 6   CD  
3  1 Y 1 A ARG 203 ? NE  ? A ARG 6   NE  
4  1 Y 1 A ARG 203 ? CZ  ? A ARG 6   CZ  
5  1 Y 1 A ARG 203 ? NH1 ? A ARG 6   NH1 
6  1 Y 1 A ARG 203 ? NH2 ? A ARG 6   NH2 
7  1 Y 1 A GLU 284 ? CG  ? A GLU 87  CG  
8  1 Y 1 A GLU 284 ? CD  ? A GLU 87  CD  
9  1 Y 1 A GLU 284 ? OE1 ? A GLU 87  OE1 
10 1 Y 1 A GLU 284 ? OE2 ? A GLU 87  OE2 
11 1 Y 1 A ALA 368 ? CB  ? A ALA 171 CB  
12 1 Y 1 A LYS 391 ? CG  ? A LYS 194 CG  
13 1 Y 1 A LYS 391 ? CD  ? A LYS 194 CD  
14 1 Y 1 A LYS 391 ? CE  ? A LYS 194 CE  
15 1 Y 1 A LYS 391 ? NZ  ? A LYS 194 NZ  
16 1 Y 1 A LYS 490 ? CG  ? A LYS 293 CG  
17 1 Y 1 A LYS 490 ? CD  ? A LYS 293 CD  
18 1 Y 1 A LYS 490 ? CE  ? A LYS 293 CE  
19 1 Y 1 A LYS 490 ? NZ  ? A LYS 293 NZ  
20 1 Y 1 A ILE 501 ? CG1 ? A ILE 304 CG1 
21 1 Y 1 A ILE 501 ? CG2 ? A ILE 304 CG2 
22 1 Y 1 A ILE 501 ? CD1 ? A ILE 304 CD1 
23 1 Y 1 A LYS 502 ? CG  ? A LYS 305 CG  
24 1 Y 1 A LYS 502 ? CD  ? A LYS 305 CD  
25 1 Y 1 A LYS 502 ? CE  ? A LYS 305 CE  
26 1 Y 1 A LYS 502 ? NZ  ? A LYS 305 NZ  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC ? ? ? 5.8.0267 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .        2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .        3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? MOLREP ? ? ? .        4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9J9D 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     42.455 
_cell.length_a_esd                 ? 
_cell.length_b                     75.677 
_cell.length_b_esd                 ? 
_cell.length_c                     89.625 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9J9D 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9J9D 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.06 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          40.28 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              8.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '20-25% PEG8000, 0.2 M Na acetate, 0.1 M Tris-HCl pH8.5' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            277 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-05-25 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.900 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SPRING-8 BEAMLINE BL44XU' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.900 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL44XU 
_diffrn_source.pdbx_synchrotron_site       SPring-8 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9J9D 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.337 
_reflns.d_resolution_low                               50 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     66655 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.2 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                3.52 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          12.6 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.998 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.337 
_reflns_shell.d_res_low                                     1.42 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             20131 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.727 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            0.001 
_refine.aniso_B[1][2]                            0.000 
_refine.aniso_B[1][3]                            -0.000 
_refine.aniso_B[2][2]                            0.003 
_refine.aniso_B[2][3]                            -0.000 
_refine.aniso_B[3][3]                            -0.004 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               12.503 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.959 
_refine.correlation_coeff_Fo_to_Fc_free          0.949 
_refine.details                                  'Hydrogens have been added in their riding positions' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9J9D 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.337 
_refine.ls_d_res_low                             44.813 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     65785 
_refine.ls_number_reflns_R_free                  3290 
_refine.ls_number_reflns_R_work                  62495 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.516 
_refine.ls_percent_reflns_R_free                 5.001 
_refine.ls_R_factor_all                          0.191 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       0.2089 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1903 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'MASK BULK SOLVENT' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      2WOU 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.059 
_refine.pdbx_overall_ESU_R_Free                  0.059 
_refine.pdbx_solvent_vdw_probe_radii             1.200 
_refine.pdbx_solvent_ion_probe_radii             0.800 
_refine.pdbx_solvent_shrinkage_radii             0.800 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             0.883 
_refine.overall_SU_ML                            0.037 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.337 
_refine_hist.d_res_low                        44.813 
_refine_hist.number_atoms_solvent             225 
_refine_hist.number_atoms_total               2624 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2351 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         48 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.003  0.013  2539 ? r_bond_refined_d               ? ? 
'X-RAY DIFFRACTION' ? 0.003  0.017  2412 ? r_bond_other_d                 ? ? 
'X-RAY DIFFRACTION' ? 1.203  1.647  3443 ? r_angle_refined_deg            ? ? 
'X-RAY DIFFRACTION' ? 1.224  1.583  5540 ? r_angle_other_deg              ? ? 
'X-RAY DIFFRACTION' ? 6.626  5.000  319  ? r_dihedral_angle_1_deg         ? ? 
'X-RAY DIFFRACTION' ? 28.311 20.685 146  ? r_dihedral_angle_2_deg         ? ? 
'X-RAY DIFFRACTION' ? 0.012  10.000 1    ? r_dihedral_angle_other_2_deg   ? ? 
'X-RAY DIFFRACTION' ? 10.770 15.000 448  ? r_dihedral_angle_3_deg         ? ? 
'X-RAY DIFFRACTION' ? 13.352 15.000 24   ? r_dihedral_angle_4_deg         ? ? 
'X-RAY DIFFRACTION' ? 0.053  0.200  325  ? r_chiral_restr                 ? ? 
'X-RAY DIFFRACTION' ? 0.004  0.020  2878 ? r_gen_planes_refined           ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.020  621  ? r_gen_planes_other             ? ? 
'X-RAY DIFFRACTION' ? 0.193  0.200  438  ? r_nbd_refined                  ? ? 
'X-RAY DIFFRACTION' ? 0.168  0.200  2127 ? r_symmetry_nbd_other           ? ? 
'X-RAY DIFFRACTION' ? 0.154  0.200  1193 ? r_nbtor_refined                ? ? 
'X-RAY DIFFRACTION' ? 0.078  0.200  983  ? r_symmetry_nbtor_other         ? ? 
'X-RAY DIFFRACTION' ? 0.095  0.200  164  ? r_xyhbond_nbd_refined          ? ? 
'X-RAY DIFFRACTION' ? 0.129  0.200  12   ? r_symmetry_nbd_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.145  0.200  54   ? r_nbd_other                    ? ? 
'X-RAY DIFFRACTION' ? 0.132  0.200  18   ? r_symmetry_xyhbond_nbd_refined ? ? 
'X-RAY DIFFRACTION' ? 0.583  1.270  1207 ? r_mcbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 0.583  1.269  1206 ? r_mcbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 1.054  1.898  1510 ? r_mcangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 1.053  1.899  1511 ? r_mcangle_other                ? ? 
'X-RAY DIFFRACTION' ? 0.634  1.316  1332 ? r_scbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 0.634  1.317  1333 ? r_scbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 1.046  1.943  1917 ? r_scangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 1.046  1.944  1918 ? r_scangle_other                ? ? 
'X-RAY DIFFRACTION' ? 2.684  14.540 2892 ? r_lrange_it                    ? ? 
'X-RAY DIFFRACTION' ? 2.603  14.339 2861 ? r_lrange_other                 ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.337 1.372  4843 . 236 4483 97.4396  . 0.252 . . 0.252 . . . . . 0.231 . 20 . 0.880 0.878 0.257 
'X-RAY DIFFRACTION' 1.372 1.409  4672 . 233 4430 99.8074  . 0.224 . . 0.223 . . . . . 0.203 . 20 . 0.912 0.907 0.241 
'X-RAY DIFFRACTION' 1.409 1.450  4565 . 227 4307 99.3209  . 0.213 . . 0.213 . . . . . 0.192 . 20 . 0.928 0.935 0.209 
'X-RAY DIFFRACTION' 1.450 1.495  4449 . 222 4211 99.6404  . 0.206 . . 0.205 . . . . . 0.183 . 20 . 0.940 0.935 0.217 
'X-RAY DIFFRACTION' 1.495 1.543  4331 . 216 4107 99.8153  . 0.197 . . 0.196 . . . . . 0.175 . 20 . 0.943 0.936 0.217 
'X-RAY DIFFRACTION' 1.543 1.598  4162 . 208 3951 99.9279  . 0.190 . . 0.190 . . . . . 0.168 . 20 . 0.949 0.951 0.187 
'X-RAY DIFFRACTION' 1.598 1.658  4037 . 201 3826 99.7523  . 0.195 . . 0.195 . . . . . 0.175 . 20 . 0.946 0.946 0.192 
'X-RAY DIFFRACTION' 1.658 1.725  3897 . 194 3681 99.4355  . 0.195 . . 0.195 . . . . . 0.175 . 20 . 0.950 0.955 0.183 
'X-RAY DIFFRACTION' 1.725 1.802  3736 . 187 3548 99.9732  . 0.195 . . 0.193 . . . . . 0.176 . 20 . 0.945 0.936 0.221 
'X-RAY DIFFRACTION' 1.802 1.890  3575 . 178 3380 99.5245  . 0.194 . . 0.192 . . . . . 0.178 . 20 . 0.950 0.949 0.213 
'X-RAY DIFFRACTION' 1.890 1.992  3424 . 171 3253 100.0000 . 0.194 . . 0.192 . . . . . 0.181 . 20 . 0.947 0.936 0.225 
'X-RAY DIFFRACTION' 1.992 2.112  3239 . 162 3077 100.0000 . 0.177 . . 0.175 . . . . . 0.172 . 20 . 0.961 0.954 0.197 
'X-RAY DIFFRACTION' 2.112 2.258  3043 . 152 2889 99.9343  . 0.173 . . 0.172 . . . . . 0.172 . 20 . 0.959 0.958 0.195 
'X-RAY DIFFRACTION' 2.258 2.438  2839 . 142 2696 99.9648  . 0.186 . . 0.185 . . . . . 0.191 . 20 . 0.954 0.949 0.203 
'X-RAY DIFFRACTION' 2.438 2.670  2637 . 131 2503 99.8862  . 0.187 . . 0.186 . . . . . 0.197 . 20 . 0.953 0.946 0.210 
'X-RAY DIFFRACTION' 2.670 2.984  2393 . 120 2267 99.7493  . 0.190 . . 0.188 . . . . . 0.205 . 20 . 0.951 0.944 0.216 
'X-RAY DIFFRACTION' 2.984 3.443  2138 . 105 2008 98.8307  . 0.177 . . 0.175 . . . . . 0.199 . 20 . 0.960 0.952 0.204 
'X-RAY DIFFRACTION' 3.443 4.211  1815 . 90  1704 98.8430  . 0.172 . . 0.172 . . . . . 0.200 . 20 . 0.967 0.970 0.172 
'X-RAY DIFFRACTION' 4.211 5.929  1445 . 72  1367 99.5848  . 0.187 . . 0.186 . . . . . 0.231 . 20 . 0.968 0.959 0.223 
'X-RAY DIFFRACTION' 5.929 44.813 864  . 43  807  98.3796  . 0.243 . . 0.241 . . . . . 0.291 . 20 . 0.941 0.937 0.285 
# 
_struct.entry_id                     9J9D 
_struct.title                        'Crystal structure of ALK5 kinase domain in complex with inhibitor HM-279' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9J9D 
_struct_keywords.text            'Protein kinase, Inhibitor complex, Oncoprotein' 
_struct_keywords.pdbx_keywords   ONCOPROTEIN 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 3 ? 
E N N 3 ? 
F N N 3 ? 
G N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    TGFR1_HUMAN 
_struct_ref.pdbx_db_accession          P36897 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;TIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLV
SDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHD
SATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVE
EMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
;
_struct_ref.pdbx_align_begin           200 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9J9D 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 3 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 306 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P36897 
_struct_ref_seq.db_align_beg                  200 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  503 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       200 
_struct_ref_seq.pdbx_auth_seq_align_end       503 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9J9D GLY A 1 ? UNP P36897 ? ? 'expression tag' 198 1 
1 9J9D ALA A 2 ? UNP P36897 ? ? 'expression tag' 199 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 620   ? 
1 MORE         9     ? 
1 'SSA (A^2)'  14170 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 38  ? ARG A 40  ? SER A 235 ARG A 237 5 ? 3  
HELX_P HELX_P2  AA2 GLU A 41  ? GLN A 53  ? GLU A 238 GLN A 250 1 ? 13 
HELX_P HELX_P3  AA3 SER A 90  ? TYR A 98  ? SER A 287 TYR A 295 1 ? 9  
HELX_P HELX_P4  AA4 THR A 101 ? MET A 121 ? THR A 298 MET A 318 1 ? 21 
HELX_P HELX_P5  AA5 LYS A 138 ? LYS A 140 ? LYS A 335 LYS A 337 5 ? 3  
HELX_P HELX_P6  AA6 THR A 178 ? MET A 182 ? THR A 375 MET A 379 5 ? 5  
HELX_P HELX_P7  AA7 ALA A 183 ? ASP A 188 ? ALA A 380 ASP A 385 1 ? 6  
HELX_P HELX_P8  AA8 HIS A 195 ? ARG A 217 ? HIS A 392 ARG A 414 1 ? 23 
HELX_P HELX_P9  AA9 SER A 240 ? CYS A 249 ? SER A 437 CYS A 446 1 ? 10 
HELX_P HELX_P10 AB1 PRO A 258 ? SER A 263 ? PRO A 455 SER A 460 5 ? 6  
HELX_P HELX_P11 AB2 CYS A 264 ? TRP A 278 ? CYS A 461 TRP A 475 1 ? 15 
HELX_P HELX_P12 AB3 ASN A 281 ? ARG A 285 ? ASN A 478 ARG A 482 5 ? 5  
HELX_P HELX_P13 AB4 THR A 287 ? GLN A 300 ? THR A 484 GLN A 497 1 ? 14 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 3 ? 
AA3 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA3 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ILE A 8   ? SER A 13  ? ILE A 205 SER A 210 
AA1 2 GLU A 21  ? TRP A 27  ? GLU A 218 TRP A 224 
AA1 3 GLU A 30  ? PHE A 37  ? GLU A 227 PHE A 234 
AA1 4 THR A 77  ? ASP A 84  ? THR A 274 ASP A 281 
AA1 5 PHE A 65  ? ASP A 72  ? PHE A 262 ASP A 269 
AA2 1 ILE A 132 ? ALA A 133 ? ILE A 329 ALA A 330 
AA2 2 VAL A 159 ? ASP A 162 ? VAL A 356 ASP A 359 
AA2 3 THR A 167 ? ILE A 168 ? THR A 364 ILE A 365 
AA3 1 ILE A 142 ? VAL A 144 ? ILE A 339 VAL A 341 
AA3 2 CYS A 150 ? ILE A 152 ? CYS A 347 ILE A 349 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N GLN A 11  ? N GLN A 208 O ARG A 24  ? O ARG A 221 
AA1 2 3 N GLU A 21  ? N GLU A 218 O ILE A 36  ? O ILE A 233 
AA1 3 4 N PHE A 37  ? N PHE A 234 O LEU A 79  ? O LEU A 276 
AA1 4 5 O VAL A 82  ? O VAL A 279 N ALA A 67  ? N ALA A 264 
AA2 1 2 N ALA A 133 ? N ALA A 330 O VAL A 159 ? O VAL A 356 
AA2 2 3 N ASP A 162 ? N ASP A 359 O THR A 167 ? O THR A 364 
AA3 1 2 N LEU A 143 ? N LEU A 340 O CYS A 151 ? O CYS A 348 
# 
_pdbx_entry_details.entry_id                   9J9D 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ARG A 332 ? ? 79.18   -0.61 
2 1 ARG A 332 ? ? 79.75   -1.31 
3 1 ASP A 333 ? ? -149.32 40.62 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 198 ? A GLY 1   
2  1 Y 1 A ALA 199 ? A ALA 2   
3  1 Y 1 A THR 200 ? A THR 3   
4  1 Y 1 A ILE 201 ? A ILE 4   
5  1 Y 1 A LYS 213 ? A LYS 16  
6  1 Y 1 A GLY 214 ? A GLY 17  
7  1 Y 1 A ARG 215 ? A ARG 18  
8  1 Y 1 A ASN 370 ? A ASN 173 
9  1 Y 1 A HIS 371 ? A HIS 174 
10 1 Y 1 A MET 503 ? A MET 306 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1L30 C2   C Y N 1   
A1L30 C4   C Y N 2   
A1L30 C5   C Y N 3   
A1L30 C7   C Y N 4   
A1L30 C8   C Y N 5   
A1L30 C9   C Y N 6   
A1L30 C10  C Y N 7   
A1L30 C12  C N N 8   
A1L30 C15  C Y N 9   
A1L30 C16  C Y N 10  
A1L30 C19  C Y N 11  
A1L30 N1   N N N 12  
A1L30 N3   N Y N 13  
A1L30 S6   S Y N 14  
A1L30 N11  N Y N 15  
A1L30 N13  N N N 16  
A1L30 O14  O N N 17  
A1L30 N17  N Y N 18  
A1L30 N18  N Y N 19  
A1L30 C20  C N N 20  
A1L30 C21  C N N 21  
A1L30 C22  C N N 22  
A1L30 C23  C N N 23  
A1L30 C24  C N N 24  
A1L30 C25  C N N 25  
A1L30 C26  C N N 26  
A1L30 C27  C N N 27  
A1L30 C28  C N N 28  
A1L30 O29  O N N 29  
A1L30 N30  N N N 30  
A1L30 C31  C N N 31  
A1L30 C32  C N N 32  
A1L30 H8   H N N 33  
A1L30 H10  H N N 34  
A1L30 H16  H N N 35  
A1L30 H19  H N N 36  
A1L30 H34  H N N 37  
A1L30 H36  H N N 38  
A1L30 H35  H N N 39  
A1L30 H201 H N N 40  
A1L30 H20  H N N 41  
A1L30 H232 H N N 42  
A1L30 H23  H N N 43  
A1L30 H231 H N N 44  
A1L30 H24  H N N 45  
A1L30 H241 H N N 46  
A1L30 H25  H N N 47  
A1L30 H261 H N N 48  
A1L30 H26  H N N 49  
A1L30 H27  H N N 50  
A1L30 H271 H N N 51  
A1L30 H311 H N N 52  
A1L30 H31  H N N 53  
A1L30 H312 H N N 54  
A1L30 H321 H N N 55  
A1L30 H322 H N N 56  
A1L30 H32  H N N 57  
ALA   N    N N N 58  
ALA   CA   C N S 59  
ALA   C    C N N 60  
ALA   O    O N N 61  
ALA   CB   C N N 62  
ALA   OXT  O N N 63  
ALA   H    H N N 64  
ALA   H2   H N N 65  
ALA   HA   H N N 66  
ALA   HB1  H N N 67  
ALA   HB2  H N N 68  
ALA   HB3  H N N 69  
ALA   HXT  H N N 70  
ARG   N    N N N 71  
ARG   CA   C N S 72  
ARG   C    C N N 73  
ARG   O    O N N 74  
ARG   CB   C N N 75  
ARG   CG   C N N 76  
ARG   CD   C N N 77  
ARG   NE   N N N 78  
ARG   CZ   C N N 79  
ARG   NH1  N N N 80  
ARG   NH2  N N N 81  
ARG   OXT  O N N 82  
ARG   H    H N N 83  
ARG   H2   H N N 84  
ARG   HA   H N N 85  
ARG   HB2  H N N 86  
ARG   HB3  H N N 87  
ARG   HG2  H N N 88  
ARG   HG3  H N N 89  
ARG   HD2  H N N 90  
ARG   HD3  H N N 91  
ARG   HE   H N N 92  
ARG   HH11 H N N 93  
ARG   HH12 H N N 94  
ARG   HH21 H N N 95  
ARG   HH22 H N N 96  
ARG   HXT  H N N 97  
ASN   N    N N N 98  
ASN   CA   C N S 99  
ASN   C    C N N 100 
ASN   O    O N N 101 
ASN   CB   C N N 102 
ASN   CG   C N N 103 
ASN   OD1  O N N 104 
ASN   ND2  N N N 105 
ASN   OXT  O N N 106 
ASN   H    H N N 107 
ASN   H2   H N N 108 
ASN   HA   H N N 109 
ASN   HB2  H N N 110 
ASN   HB3  H N N 111 
ASN   HD21 H N N 112 
ASN   HD22 H N N 113 
ASN   HXT  H N N 114 
ASP   N    N N N 115 
ASP   CA   C N S 116 
ASP   C    C N N 117 
ASP   O    O N N 118 
ASP   CB   C N N 119 
ASP   CG   C N N 120 
ASP   OD1  O N N 121 
ASP   OD2  O N N 122 
ASP   OXT  O N N 123 
ASP   H    H N N 124 
ASP   H2   H N N 125 
ASP   HA   H N N 126 
ASP   HB2  H N N 127 
ASP   HB3  H N N 128 
ASP   HD2  H N N 129 
ASP   HXT  H N N 130 
CYS   N    N N N 131 
CYS   CA   C N R 132 
CYS   C    C N N 133 
CYS   O    O N N 134 
CYS   CB   C N N 135 
CYS   SG   S N N 136 
CYS   OXT  O N N 137 
CYS   H    H N N 138 
CYS   H2   H N N 139 
CYS   HA   H N N 140 
CYS   HB2  H N N 141 
CYS   HB3  H N N 142 
CYS   HG   H N N 143 
CYS   HXT  H N N 144 
EDO   C1   C N N 145 
EDO   O1   O N N 146 
EDO   C2   C N N 147 
EDO   O2   O N N 148 
EDO   H11  H N N 149 
EDO   H12  H N N 150 
EDO   HO1  H N N 151 
EDO   H21  H N N 152 
EDO   H22  H N N 153 
EDO   HO2  H N N 154 
GLN   N    N N N 155 
GLN   CA   C N S 156 
GLN   C    C N N 157 
GLN   O    O N N 158 
GLN   CB   C N N 159 
GLN   CG   C N N 160 
GLN   CD   C N N 161 
GLN   OE1  O N N 162 
GLN   NE2  N N N 163 
GLN   OXT  O N N 164 
GLN   H    H N N 165 
GLN   H2   H N N 166 
GLN   HA   H N N 167 
GLN   HB2  H N N 168 
GLN   HB3  H N N 169 
GLN   HG2  H N N 170 
GLN   HG3  H N N 171 
GLN   HE21 H N N 172 
GLN   HE22 H N N 173 
GLN   HXT  H N N 174 
GLU   N    N N N 175 
GLU   CA   C N S 176 
GLU   C    C N N 177 
GLU   O    O N N 178 
GLU   CB   C N N 179 
GLU   CG   C N N 180 
GLU   CD   C N N 181 
GLU   OE1  O N N 182 
GLU   OE2  O N N 183 
GLU   OXT  O N N 184 
GLU   H    H N N 185 
GLU   H2   H N N 186 
GLU   HA   H N N 187 
GLU   HB2  H N N 188 
GLU   HB3  H N N 189 
GLU   HG2  H N N 190 
GLU   HG3  H N N 191 
GLU   HE2  H N N 192 
GLU   HXT  H N N 193 
GLY   N    N N N 194 
GLY   CA   C N N 195 
GLY   C    C N N 196 
GLY   O    O N N 197 
GLY   OXT  O N N 198 
GLY   H    H N N 199 
GLY   H2   H N N 200 
GLY   HA2  H N N 201 
GLY   HA3  H N N 202 
GLY   HXT  H N N 203 
HIS   N    N N N 204 
HIS   CA   C N S 205 
HIS   C    C N N 206 
HIS   O    O N N 207 
HIS   CB   C N N 208 
HIS   CG   C Y N 209 
HIS   ND1  N Y N 210 
HIS   CD2  C Y N 211 
HIS   CE1  C Y N 212 
HIS   NE2  N Y N 213 
HIS   OXT  O N N 214 
HIS   H    H N N 215 
HIS   H2   H N N 216 
HIS   HA   H N N 217 
HIS   HB2  H N N 218 
HIS   HB3  H N N 219 
HIS   HD1  H N N 220 
HIS   HD2  H N N 221 
HIS   HE1  H N N 222 
HIS   HE2  H N N 223 
HIS   HXT  H N N 224 
HOH   O    O N N 225 
HOH   H1   H N N 226 
HOH   H2   H N N 227 
ILE   N    N N N 228 
ILE   CA   C N S 229 
ILE   C    C N N 230 
ILE   O    O N N 231 
ILE   CB   C N S 232 
ILE   CG1  C N N 233 
ILE   CG2  C N N 234 
ILE   CD1  C N N 235 
ILE   OXT  O N N 236 
ILE   H    H N N 237 
ILE   H2   H N N 238 
ILE   HA   H N N 239 
ILE   HB   H N N 240 
ILE   HG12 H N N 241 
ILE   HG13 H N N 242 
ILE   HG21 H N N 243 
ILE   HG22 H N N 244 
ILE   HG23 H N N 245 
ILE   HD11 H N N 246 
ILE   HD12 H N N 247 
ILE   HD13 H N N 248 
ILE   HXT  H N N 249 
LEU   N    N N N 250 
LEU   CA   C N S 251 
LEU   C    C N N 252 
LEU   O    O N N 253 
LEU   CB   C N N 254 
LEU   CG   C N N 255 
LEU   CD1  C N N 256 
LEU   CD2  C N N 257 
LEU   OXT  O N N 258 
LEU   H    H N N 259 
LEU   H2   H N N 260 
LEU   HA   H N N 261 
LEU   HB2  H N N 262 
LEU   HB3  H N N 263 
LEU   HG   H N N 264 
LEU   HD11 H N N 265 
LEU   HD12 H N N 266 
LEU   HD13 H N N 267 
LEU   HD21 H N N 268 
LEU   HD22 H N N 269 
LEU   HD23 H N N 270 
LEU   HXT  H N N 271 
LYS   N    N N N 272 
LYS   CA   C N S 273 
LYS   C    C N N 274 
LYS   O    O N N 275 
LYS   CB   C N N 276 
LYS   CG   C N N 277 
LYS   CD   C N N 278 
LYS   CE   C N N 279 
LYS   NZ   N N N 280 
LYS   OXT  O N N 281 
LYS   H    H N N 282 
LYS   H2   H N N 283 
LYS   HA   H N N 284 
LYS   HB2  H N N 285 
LYS   HB3  H N N 286 
LYS   HG2  H N N 287 
LYS   HG3  H N N 288 
LYS   HD2  H N N 289 
LYS   HD3  H N N 290 
LYS   HE2  H N N 291 
LYS   HE3  H N N 292 
LYS   HZ1  H N N 293 
LYS   HZ2  H N N 294 
LYS   HZ3  H N N 295 
LYS   HXT  H N N 296 
MET   N    N N N 297 
MET   CA   C N S 298 
MET   C    C N N 299 
MET   O    O N N 300 
MET   CB   C N N 301 
MET   CG   C N N 302 
MET   SD   S N N 303 
MET   CE   C N N 304 
MET   OXT  O N N 305 
MET   H    H N N 306 
MET   H2   H N N 307 
MET   HA   H N N 308 
MET   HB2  H N N 309 
MET   HB3  H N N 310 
MET   HG2  H N N 311 
MET   HG3  H N N 312 
MET   HE1  H N N 313 
MET   HE2  H N N 314 
MET   HE3  H N N 315 
MET   HXT  H N N 316 
PHE   N    N N N 317 
PHE   CA   C N S 318 
PHE   C    C N N 319 
PHE   O    O N N 320 
PHE   CB   C N N 321 
PHE   CG   C Y N 322 
PHE   CD1  C Y N 323 
PHE   CD2  C Y N 324 
PHE   CE1  C Y N 325 
PHE   CE2  C Y N 326 
PHE   CZ   C Y N 327 
PHE   OXT  O N N 328 
PHE   H    H N N 329 
PHE   H2   H N N 330 
PHE   HA   H N N 331 
PHE   HB2  H N N 332 
PHE   HB3  H N N 333 
PHE   HD1  H N N 334 
PHE   HD2  H N N 335 
PHE   HE1  H N N 336 
PHE   HE2  H N N 337 
PHE   HZ   H N N 338 
PHE   HXT  H N N 339 
PRO   N    N N N 340 
PRO   CA   C N S 341 
PRO   C    C N N 342 
PRO   O    O N N 343 
PRO   CB   C N N 344 
PRO   CG   C N N 345 
PRO   CD   C N N 346 
PRO   OXT  O N N 347 
PRO   H    H N N 348 
PRO   HA   H N N 349 
PRO   HB2  H N N 350 
PRO   HB3  H N N 351 
PRO   HG2  H N N 352 
PRO   HG3  H N N 353 
PRO   HD2  H N N 354 
PRO   HD3  H N N 355 
PRO   HXT  H N N 356 
SER   N    N N N 357 
SER   CA   C N S 358 
SER   C    C N N 359 
SER   O    O N N 360 
SER   CB   C N N 361 
SER   OG   O N N 362 
SER   OXT  O N N 363 
SER   H    H N N 364 
SER   H2   H N N 365 
SER   HA   H N N 366 
SER   HB2  H N N 367 
SER   HB3  H N N 368 
SER   HG   H N N 369 
SER   HXT  H N N 370 
THR   N    N N N 371 
THR   CA   C N S 372 
THR   C    C N N 373 
THR   O    O N N 374 
THR   CB   C N R 375 
THR   OG1  O N N 376 
THR   CG2  C N N 377 
THR   OXT  O N N 378 
THR   H    H N N 379 
THR   H2   H N N 380 
THR   HA   H N N 381 
THR   HB   H N N 382 
THR   HG1  H N N 383 
THR   HG21 H N N 384 
THR   HG22 H N N 385 
THR   HG23 H N N 386 
THR   HXT  H N N 387 
TRP   N    N N N 388 
TRP   CA   C N S 389 
TRP   C    C N N 390 
TRP   O    O N N 391 
TRP   CB   C N N 392 
TRP   CG   C Y N 393 
TRP   CD1  C Y N 394 
TRP   CD2  C Y N 395 
TRP   NE1  N Y N 396 
TRP   CE2  C Y N 397 
TRP   CE3  C Y N 398 
TRP   CZ2  C Y N 399 
TRP   CZ3  C Y N 400 
TRP   CH2  C Y N 401 
TRP   OXT  O N N 402 
TRP   H    H N N 403 
TRP   H2   H N N 404 
TRP   HA   H N N 405 
TRP   HB2  H N N 406 
TRP   HB3  H N N 407 
TRP   HD1  H N N 408 
TRP   HE1  H N N 409 
TRP   HE3  H N N 410 
TRP   HZ2  H N N 411 
TRP   HZ3  H N N 412 
TRP   HH2  H N N 413 
TRP   HXT  H N N 414 
TYR   N    N N N 415 
TYR   CA   C N S 416 
TYR   C    C N N 417 
TYR   O    O N N 418 
TYR   CB   C N N 419 
TYR   CG   C Y N 420 
TYR   CD1  C Y N 421 
TYR   CD2  C Y N 422 
TYR   CE1  C Y N 423 
TYR   CE2  C Y N 424 
TYR   CZ   C Y N 425 
TYR   OH   O N N 426 
TYR   OXT  O N N 427 
TYR   H    H N N 428 
TYR   H2   H N N 429 
TYR   HA   H N N 430 
TYR   HB2  H N N 431 
TYR   HB3  H N N 432 
TYR   HD1  H N N 433 
TYR   HD2  H N N 434 
TYR   HE1  H N N 435 
TYR   HE2  H N N 436 
TYR   HH   H N N 437 
TYR   HXT  H N N 438 
VAL   N    N N N 439 
VAL   CA   C N S 440 
VAL   C    C N N 441 
VAL   O    O N N 442 
VAL   CB   C N N 443 
VAL   CG1  C N N 444 
VAL   CG2  C N N 445 
VAL   OXT  O N N 446 
VAL   H    H N N 447 
VAL   H2   H N N 448 
VAL   HA   H N N 449 
VAL   HB   H N N 450 
VAL   HG11 H N N 451 
VAL   HG12 H N N 452 
VAL   HG13 H N N 453 
VAL   HG21 H N N 454 
VAL   HG22 H N N 455 
VAL   HG23 H N N 456 
VAL   HXT  H N N 457 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1L30 N1  C2   sing N N 1   
A1L30 N1  C15  sing N N 2   
A1L30 N1  C24  sing N N 3   
A1L30 C2  N3   doub Y N 4   
A1L30 C2  S6   sing Y N 5   
A1L30 N3  C4   sing Y N 6   
A1L30 C4  C5   doub Y N 7   
A1L30 C4  C12  sing N N 8   
A1L30 C5  S6   sing Y N 9   
A1L30 C5  C7   sing N N 10  
A1L30 C7  C8   doub Y N 11  
A1L30 C7  N11  sing Y N 12  
A1L30 C8  C9   sing Y N 13  
A1L30 C9  C10  doub Y N 14  
A1L30 C9  C28  sing N N 15  
A1L30 C10 N11  sing Y N 16  
A1L30 C12 N13  sing N N 17  
A1L30 C12 O14  doub N N 18  
A1L30 C15 C16  doub Y N 19  
A1L30 C15 C19  sing Y N 20  
A1L30 C16 N17  sing Y N 21  
A1L30 N17 N18  sing Y N 22  
A1L30 N17 C20  sing N N 23  
A1L30 N18 C19  doub Y N 24  
A1L30 C20 C21  sing N N 25  
A1L30 C21 C22  trip N N 26  
A1L30 C22 C23  sing N N 27  
A1L30 C24 C25  sing N N 28  
A1L30 C25 C26  sing N N 29  
A1L30 C25 C27  sing N N 30  
A1L30 C26 C27  sing N N 31  
A1L30 C28 O29  doub N N 32  
A1L30 C28 N30  sing N N 33  
A1L30 N30 C31  sing N N 34  
A1L30 N30 C32  sing N N 35  
A1L30 C8  H8   sing N N 36  
A1L30 C10 H10  sing N N 37  
A1L30 C16 H16  sing N N 38  
A1L30 C19 H19  sing N N 39  
A1L30 N11 H34  sing N N 40  
A1L30 N13 H36  sing N N 41  
A1L30 N13 H35  sing N N 42  
A1L30 C20 H201 sing N N 43  
A1L30 C20 H20  sing N N 44  
A1L30 C23 H232 sing N N 45  
A1L30 C23 H23  sing N N 46  
A1L30 C23 H231 sing N N 47  
A1L30 C24 H24  sing N N 48  
A1L30 C24 H241 sing N N 49  
A1L30 C25 H25  sing N N 50  
A1L30 C26 H261 sing N N 51  
A1L30 C26 H26  sing N N 52  
A1L30 C27 H27  sing N N 53  
A1L30 C27 H271 sing N N 54  
A1L30 C31 H311 sing N N 55  
A1L30 C31 H31  sing N N 56  
A1L30 C31 H312 sing N N 57  
A1L30 C32 H321 sing N N 58  
A1L30 C32 H322 sing N N 59  
A1L30 C32 H32  sing N N 60  
ALA   N   CA   sing N N 61  
ALA   N   H    sing N N 62  
ALA   N   H2   sing N N 63  
ALA   CA  C    sing N N 64  
ALA   CA  CB   sing N N 65  
ALA   CA  HA   sing N N 66  
ALA   C   O    doub N N 67  
ALA   C   OXT  sing N N 68  
ALA   CB  HB1  sing N N 69  
ALA   CB  HB2  sing N N 70  
ALA   CB  HB3  sing N N 71  
ALA   OXT HXT  sing N N 72  
ARG   N   CA   sing N N 73  
ARG   N   H    sing N N 74  
ARG   N   H2   sing N N 75  
ARG   CA  C    sing N N 76  
ARG   CA  CB   sing N N 77  
ARG   CA  HA   sing N N 78  
ARG   C   O    doub N N 79  
ARG   C   OXT  sing N N 80  
ARG   CB  CG   sing N N 81  
ARG   CB  HB2  sing N N 82  
ARG   CB  HB3  sing N N 83  
ARG   CG  CD   sing N N 84  
ARG   CG  HG2  sing N N 85  
ARG   CG  HG3  sing N N 86  
ARG   CD  NE   sing N N 87  
ARG   CD  HD2  sing N N 88  
ARG   CD  HD3  sing N N 89  
ARG   NE  CZ   sing N N 90  
ARG   NE  HE   sing N N 91  
ARG   CZ  NH1  sing N N 92  
ARG   CZ  NH2  doub N N 93  
ARG   NH1 HH11 sing N N 94  
ARG   NH1 HH12 sing N N 95  
ARG   NH2 HH21 sing N N 96  
ARG   NH2 HH22 sing N N 97  
ARG   OXT HXT  sing N N 98  
ASN   N   CA   sing N N 99  
ASN   N   H    sing N N 100 
ASN   N   H2   sing N N 101 
ASN   CA  C    sing N N 102 
ASN   CA  CB   sing N N 103 
ASN   CA  HA   sing N N 104 
ASN   C   O    doub N N 105 
ASN   C   OXT  sing N N 106 
ASN   CB  CG   sing N N 107 
ASN   CB  HB2  sing N N 108 
ASN   CB  HB3  sing N N 109 
ASN   CG  OD1  doub N N 110 
ASN   CG  ND2  sing N N 111 
ASN   ND2 HD21 sing N N 112 
ASN   ND2 HD22 sing N N 113 
ASN   OXT HXT  sing N N 114 
ASP   N   CA   sing N N 115 
ASP   N   H    sing N N 116 
ASP   N   H2   sing N N 117 
ASP   CA  C    sing N N 118 
ASP   CA  CB   sing N N 119 
ASP   CA  HA   sing N N 120 
ASP   C   O    doub N N 121 
ASP   C   OXT  sing N N 122 
ASP   CB  CG   sing N N 123 
ASP   CB  HB2  sing N N 124 
ASP   CB  HB3  sing N N 125 
ASP   CG  OD1  doub N N 126 
ASP   CG  OD2  sing N N 127 
ASP   OD2 HD2  sing N N 128 
ASP   OXT HXT  sing N N 129 
CYS   N   CA   sing N N 130 
CYS   N   H    sing N N 131 
CYS   N   H2   sing N N 132 
CYS   CA  C    sing N N 133 
CYS   CA  CB   sing N N 134 
CYS   CA  HA   sing N N 135 
CYS   C   O    doub N N 136 
CYS   C   OXT  sing N N 137 
CYS   CB  SG   sing N N 138 
CYS   CB  HB2  sing N N 139 
CYS   CB  HB3  sing N N 140 
CYS   SG  HG   sing N N 141 
CYS   OXT HXT  sing N N 142 
EDO   C1  O1   sing N N 143 
EDO   C1  C2   sing N N 144 
EDO   C1  H11  sing N N 145 
EDO   C1  H12  sing N N 146 
EDO   O1  HO1  sing N N 147 
EDO   C2  O2   sing N N 148 
EDO   C2  H21  sing N N 149 
EDO   C2  H22  sing N N 150 
EDO   O2  HO2  sing N N 151 
GLN   N   CA   sing N N 152 
GLN   N   H    sing N N 153 
GLN   N   H2   sing N N 154 
GLN   CA  C    sing N N 155 
GLN   CA  CB   sing N N 156 
GLN   CA  HA   sing N N 157 
GLN   C   O    doub N N 158 
GLN   C   OXT  sing N N 159 
GLN   CB  CG   sing N N 160 
GLN   CB  HB2  sing N N 161 
GLN   CB  HB3  sing N N 162 
GLN   CG  CD   sing N N 163 
GLN   CG  HG2  sing N N 164 
GLN   CG  HG3  sing N N 165 
GLN   CD  OE1  doub N N 166 
GLN   CD  NE2  sing N N 167 
GLN   NE2 HE21 sing N N 168 
GLN   NE2 HE22 sing N N 169 
GLN   OXT HXT  sing N N 170 
GLU   N   CA   sing N N 171 
GLU   N   H    sing N N 172 
GLU   N   H2   sing N N 173 
GLU   CA  C    sing N N 174 
GLU   CA  CB   sing N N 175 
GLU   CA  HA   sing N N 176 
GLU   C   O    doub N N 177 
GLU   C   OXT  sing N N 178 
GLU   CB  CG   sing N N 179 
GLU   CB  HB2  sing N N 180 
GLU   CB  HB3  sing N N 181 
GLU   CG  CD   sing N N 182 
GLU   CG  HG2  sing N N 183 
GLU   CG  HG3  sing N N 184 
GLU   CD  OE1  doub N N 185 
GLU   CD  OE2  sing N N 186 
GLU   OE2 HE2  sing N N 187 
GLU   OXT HXT  sing N N 188 
GLY   N   CA   sing N N 189 
GLY   N   H    sing N N 190 
GLY   N   H2   sing N N 191 
GLY   CA  C    sing N N 192 
GLY   CA  HA2  sing N N 193 
GLY   CA  HA3  sing N N 194 
GLY   C   O    doub N N 195 
GLY   C   OXT  sing N N 196 
GLY   OXT HXT  sing N N 197 
HIS   N   CA   sing N N 198 
HIS   N   H    sing N N 199 
HIS   N   H2   sing N N 200 
HIS   CA  C    sing N N 201 
HIS   CA  CB   sing N N 202 
HIS   CA  HA   sing N N 203 
HIS   C   O    doub N N 204 
HIS   C   OXT  sing N N 205 
HIS   CB  CG   sing N N 206 
HIS   CB  HB2  sing N N 207 
HIS   CB  HB3  sing N N 208 
HIS   CG  ND1  sing Y N 209 
HIS   CG  CD2  doub Y N 210 
HIS   ND1 CE1  doub Y N 211 
HIS   ND1 HD1  sing N N 212 
HIS   CD2 NE2  sing Y N 213 
HIS   CD2 HD2  sing N N 214 
HIS   CE1 NE2  sing Y N 215 
HIS   CE1 HE1  sing N N 216 
HIS   NE2 HE2  sing N N 217 
HIS   OXT HXT  sing N N 218 
HOH   O   H1   sing N N 219 
HOH   O   H2   sing N N 220 
ILE   N   CA   sing N N 221 
ILE   N   H    sing N N 222 
ILE   N   H2   sing N N 223 
ILE   CA  C    sing N N 224 
ILE   CA  CB   sing N N 225 
ILE   CA  HA   sing N N 226 
ILE   C   O    doub N N 227 
ILE   C   OXT  sing N N 228 
ILE   CB  CG1  sing N N 229 
ILE   CB  CG2  sing N N 230 
ILE   CB  HB   sing N N 231 
ILE   CG1 CD1  sing N N 232 
ILE   CG1 HG12 sing N N 233 
ILE   CG1 HG13 sing N N 234 
ILE   CG2 HG21 sing N N 235 
ILE   CG2 HG22 sing N N 236 
ILE   CG2 HG23 sing N N 237 
ILE   CD1 HD11 sing N N 238 
ILE   CD1 HD12 sing N N 239 
ILE   CD1 HD13 sing N N 240 
ILE   OXT HXT  sing N N 241 
LEU   N   CA   sing N N 242 
LEU   N   H    sing N N 243 
LEU   N   H2   sing N N 244 
LEU   CA  C    sing N N 245 
LEU   CA  CB   sing N N 246 
LEU   CA  HA   sing N N 247 
LEU   C   O    doub N N 248 
LEU   C   OXT  sing N N 249 
LEU   CB  CG   sing N N 250 
LEU   CB  HB2  sing N N 251 
LEU   CB  HB3  sing N N 252 
LEU   CG  CD1  sing N N 253 
LEU   CG  CD2  sing N N 254 
LEU   CG  HG   sing N N 255 
LEU   CD1 HD11 sing N N 256 
LEU   CD1 HD12 sing N N 257 
LEU   CD1 HD13 sing N N 258 
LEU   CD2 HD21 sing N N 259 
LEU   CD2 HD22 sing N N 260 
LEU   CD2 HD23 sing N N 261 
LEU   OXT HXT  sing N N 262 
LYS   N   CA   sing N N 263 
LYS   N   H    sing N N 264 
LYS   N   H2   sing N N 265 
LYS   CA  C    sing N N 266 
LYS   CA  CB   sing N N 267 
LYS   CA  HA   sing N N 268 
LYS   C   O    doub N N 269 
LYS   C   OXT  sing N N 270 
LYS   CB  CG   sing N N 271 
LYS   CB  HB2  sing N N 272 
LYS   CB  HB3  sing N N 273 
LYS   CG  CD   sing N N 274 
LYS   CG  HG2  sing N N 275 
LYS   CG  HG3  sing N N 276 
LYS   CD  CE   sing N N 277 
LYS   CD  HD2  sing N N 278 
LYS   CD  HD3  sing N N 279 
LYS   CE  NZ   sing N N 280 
LYS   CE  HE2  sing N N 281 
LYS   CE  HE3  sing N N 282 
LYS   NZ  HZ1  sing N N 283 
LYS   NZ  HZ2  sing N N 284 
LYS   NZ  HZ3  sing N N 285 
LYS   OXT HXT  sing N N 286 
MET   N   CA   sing N N 287 
MET   N   H    sing N N 288 
MET   N   H2   sing N N 289 
MET   CA  C    sing N N 290 
MET   CA  CB   sing N N 291 
MET   CA  HA   sing N N 292 
MET   C   O    doub N N 293 
MET   C   OXT  sing N N 294 
MET   CB  CG   sing N N 295 
MET   CB  HB2  sing N N 296 
MET   CB  HB3  sing N N 297 
MET   CG  SD   sing N N 298 
MET   CG  HG2  sing N N 299 
MET   CG  HG3  sing N N 300 
MET   SD  CE   sing N N 301 
MET   CE  HE1  sing N N 302 
MET   CE  HE2  sing N N 303 
MET   CE  HE3  sing N N 304 
MET   OXT HXT  sing N N 305 
PHE   N   CA   sing N N 306 
PHE   N   H    sing N N 307 
PHE   N   H2   sing N N 308 
PHE   CA  C    sing N N 309 
PHE   CA  CB   sing N N 310 
PHE   CA  HA   sing N N 311 
PHE   C   O    doub N N 312 
PHE   C   OXT  sing N N 313 
PHE   CB  CG   sing N N 314 
PHE   CB  HB2  sing N N 315 
PHE   CB  HB3  sing N N 316 
PHE   CG  CD1  doub Y N 317 
PHE   CG  CD2  sing Y N 318 
PHE   CD1 CE1  sing Y N 319 
PHE   CD1 HD1  sing N N 320 
PHE   CD2 CE2  doub Y N 321 
PHE   CD2 HD2  sing N N 322 
PHE   CE1 CZ   doub Y N 323 
PHE   CE1 HE1  sing N N 324 
PHE   CE2 CZ   sing Y N 325 
PHE   CE2 HE2  sing N N 326 
PHE   CZ  HZ   sing N N 327 
PHE   OXT HXT  sing N N 328 
PRO   N   CA   sing N N 329 
PRO   N   CD   sing N N 330 
PRO   N   H    sing N N 331 
PRO   CA  C    sing N N 332 
PRO   CA  CB   sing N N 333 
PRO   CA  HA   sing N N 334 
PRO   C   O    doub N N 335 
PRO   C   OXT  sing N N 336 
PRO   CB  CG   sing N N 337 
PRO   CB  HB2  sing N N 338 
PRO   CB  HB3  sing N N 339 
PRO   CG  CD   sing N N 340 
PRO   CG  HG2  sing N N 341 
PRO   CG  HG3  sing N N 342 
PRO   CD  HD2  sing N N 343 
PRO   CD  HD3  sing N N 344 
PRO   OXT HXT  sing N N 345 
SER   N   CA   sing N N 346 
SER   N   H    sing N N 347 
SER   N   H2   sing N N 348 
SER   CA  C    sing N N 349 
SER   CA  CB   sing N N 350 
SER   CA  HA   sing N N 351 
SER   C   O    doub N N 352 
SER   C   OXT  sing N N 353 
SER   CB  OG   sing N N 354 
SER   CB  HB2  sing N N 355 
SER   CB  HB3  sing N N 356 
SER   OG  HG   sing N N 357 
SER   OXT HXT  sing N N 358 
THR   N   CA   sing N N 359 
THR   N   H    sing N N 360 
THR   N   H2   sing N N 361 
THR   CA  C    sing N N 362 
THR   CA  CB   sing N N 363 
THR   CA  HA   sing N N 364 
THR   C   O    doub N N 365 
THR   C   OXT  sing N N 366 
THR   CB  OG1  sing N N 367 
THR   CB  CG2  sing N N 368 
THR   CB  HB   sing N N 369 
THR   OG1 HG1  sing N N 370 
THR   CG2 HG21 sing N N 371 
THR   CG2 HG22 sing N N 372 
THR   CG2 HG23 sing N N 373 
THR   OXT HXT  sing N N 374 
TRP   N   CA   sing N N 375 
TRP   N   H    sing N N 376 
TRP   N   H2   sing N N 377 
TRP   CA  C    sing N N 378 
TRP   CA  CB   sing N N 379 
TRP   CA  HA   sing N N 380 
TRP   C   O    doub N N 381 
TRP   C   OXT  sing N N 382 
TRP   CB  CG   sing N N 383 
TRP   CB  HB2  sing N N 384 
TRP   CB  HB3  sing N N 385 
TRP   CG  CD1  doub Y N 386 
TRP   CG  CD2  sing Y N 387 
TRP   CD1 NE1  sing Y N 388 
TRP   CD1 HD1  sing N N 389 
TRP   CD2 CE2  doub Y N 390 
TRP   CD2 CE3  sing Y N 391 
TRP   NE1 CE2  sing Y N 392 
TRP   NE1 HE1  sing N N 393 
TRP   CE2 CZ2  sing Y N 394 
TRP   CE3 CZ3  doub Y N 395 
TRP   CE3 HE3  sing N N 396 
TRP   CZ2 CH2  doub Y N 397 
TRP   CZ2 HZ2  sing N N 398 
TRP   CZ3 CH2  sing Y N 399 
TRP   CZ3 HZ3  sing N N 400 
TRP   CH2 HH2  sing N N 401 
TRP   OXT HXT  sing N N 402 
TYR   N   CA   sing N N 403 
TYR   N   H    sing N N 404 
TYR   N   H2   sing N N 405 
TYR   CA  C    sing N N 406 
TYR   CA  CB   sing N N 407 
TYR   CA  HA   sing N N 408 
TYR   C   O    doub N N 409 
TYR   C   OXT  sing N N 410 
TYR   CB  CG   sing N N 411 
TYR   CB  HB2  sing N N 412 
TYR   CB  HB3  sing N N 413 
TYR   CG  CD1  doub Y N 414 
TYR   CG  CD2  sing Y N 415 
TYR   CD1 CE1  sing Y N 416 
TYR   CD1 HD1  sing N N 417 
TYR   CD2 CE2  doub Y N 418 
TYR   CD2 HD2  sing N N 419 
TYR   CE1 CZ   doub Y N 420 
TYR   CE1 HE1  sing N N 421 
TYR   CE2 CZ   sing Y N 422 
TYR   CE2 HE2  sing N N 423 
TYR   CZ  OH   sing N N 424 
TYR   OH  HH   sing N N 425 
TYR   OXT HXT  sing N N 426 
VAL   N   CA   sing N N 427 
VAL   N   H    sing N N 428 
VAL   N   H2   sing N N 429 
VAL   CA  C    sing N N 430 
VAL   CA  CB   sing N N 431 
VAL   CA  HA   sing N N 432 
VAL   C   O    doub N N 433 
VAL   C   OXT  sing N N 434 
VAL   CB  CG1  sing N N 435 
VAL   CB  CG2  sing N N 436 
VAL   CB  HB   sing N N 437 
VAL   CG1 HG11 sing N N 438 
VAL   CG1 HG12 sing N N 439 
VAL   CG1 HG13 sing N N 440 
VAL   CG2 HG21 sing N N 441 
VAL   CG2 HG22 sing N N 442 
VAL   CG2 HG23 sing N N 443 
VAL   OXT HXT  sing N N 444 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   2WOU 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9J9D 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.023554 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.013214 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.011158 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.pdbx_scat_Z 
_atom_type.pdbx_N_electrons 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
C 6  6  2.310  20.844 1.020 10.208 1.589 0.569  0.865 51.651 0.216   
H 1  1  0.493  10.511 0.323 26.126 0.140 3.142  0.041 57.800 0.003   
N 7  7  12.222 0.006  3.135 9.893  2.014 28.997 1.167 0.583  -11.538 
O 8  8  3.049  13.277 2.287 5.701  1.546 0.324  0.867 32.909 0.251   
S 16 16 6.905  1.468  5.203 22.215 1.438 0.254  1.586 56.172 1.026   
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
_atom_site.calc_flag 
ATOM   1    N N   . ALA   A 1 5   ? 10.043  20.885  -3.893  1.000 21.844 0 202  ALA   A N   1 ? 
ATOM   2    C CA  . ALA   A 1 5   ? 8.736   21.333  -3.321  1.000 21.382 0 202  ALA   A CA  1 ? 
ATOM   3    C C   . ALA   A 1 5   ? 8.024   22.270  -4.302  1.000 21.132 0 202  ALA   A C   1 ? 
ATOM   4    O O   . ALA   A 1 5   ? 6.792   22.167  -4.422  1.000 21.415 0 202  ALA   A O   1 ? 
ATOM   5    C CB  . ALA   A 1 5   ? 8.955   22.004  -1.986  1.000 21.139 0 202  ALA   A CB  1 ? 
ATOM   6    N N   . ARG   A 1 6   ? 8.781   23.146  -4.972  1.000 20.295 0 203  ARG   A N   1 ? 
ATOM   7    C CA  . ARG   A 1 6   ? 8.276   24.174  -5.922  1.000 19.710 0 203  ARG   A CA  1 ? 
ATOM   8    C C   . ARG   A 1 6   ? 7.377   23.535  -6.990  1.000 18.939 0 203  ARG   A C   1 ? 
ATOM   9    O O   . ARG   A 1 6   ? 6.399   24.198  -7.389  1.000 19.644 0 203  ARG   A O   1 ? 
ATOM   10   C CB  . ARG   A 1 6   ? 9.449   24.906  -6.583  1.000 20.060 0 203  ARG   A CB  1 ? 
ATOM   11   N N   . THR   A 1 7   ? 7.691   22.310  -7.431  1.000 17.750 0 204  THR   A N   1 ? 
ATOM   12   C CA  . THR   A 1 7   ? 7.065   21.643  -8.608  1.000 17.196 0 204  THR   A CA  1 ? 
ATOM   13   C C   . THR   A 1 7   ? 6.241   20.414  -8.196  1.000 15.974 0 204  THR   A C   1 ? 
ATOM   14   O O   . THR   A 1 7   ? 5.918   19.603  -9.085  1.000 17.006 0 204  THR   A O   1 ? 
ATOM   15   C CB  . THR   A 1 7   ? 8.129   21.236  -9.637  1.000 18.284 0 204  THR   A CB  1 ? 
ATOM   16   O OG1 . THR   A 1 7   ? 8.996   20.276  -9.034  1.000 19.422 0 204  THR   A OG1 1 ? 
ATOM   17   C CG2 . THR   A 1 7   ? 8.941   22.408  -10.143 1.000 18.628 0 204  THR   A CG2 1 ? 
ATOM   18   N N   . ILE   A 1 8   ? 5.910   20.261  -6.913  1.000 13.643 0 205  ILE   A N   1 ? 
ATOM   19   C CA  . ILE   A 1 8   ? 5.035   19.150  -6.434  1.000 12.281 0 205  ILE   A CA  1 ? 
ATOM   20   C C   . ILE   A 1 8   ? 3.632   19.705  -6.178  1.000 11.215 0 205  ILE   A C   1 ? 
ATOM   21   O O   . ILE   A 1 8   ? 3.519   20.800  -5.595  1.000 11.450 0 205  ILE   A O   1 ? 
ATOM   22   C CB  . ILE   A 1 8   ? 5.623   18.459  -5.189  1.000 12.082 0 205  ILE   A CB  1 ? 
ATOM   23   C CG1 . ILE   A 1 8   ? 6.882   17.663  -5.546  1.000 12.322 0 205  ILE   A CG1 1 ? 
ATOM   24   C CG2 . ILE   A 1 8   ? 4.583   17.577  -4.515  1.000 12.144 0 205  ILE   A CG2 1 ? 
ATOM   25   C CD1 . ILE   A 1 8   ? 7.674   17.171  -4.355  1.000 12.495 0 205  ILE   A CD1 1 ? 
ATOM   26   N N   . VAL   A 1 9   ? 2.612   18.962  -6.607  1.000 10.221 0 206  VAL   A N   1 ? 
ATOM   27   C CA  . VAL   A 1 9   ? 1.176   19.297  -6.390  1.000 9.765  0 206  VAL   A CA  1 ? 
ATOM   28   C C   . VAL   A 1 9   ? 0.596   18.268  -5.417  1.000 9.455  0 206  VAL   A C   1 ? 
ATOM   29   O O   . VAL   A 1 9   ? 0.601   17.067  -5.748  1.000 9.475  0 206  VAL   A O   1 ? 
ATOM   30   C CB  . VAL   A 1 9   ? 0.403   19.329  -7.722  1.000 9.584  0 206  VAL   A CB  1 ? 
ATOM   31   C CG1 . VAL   A 1 9   ? -1.077  19.626  -7.510  1.000 9.498  0 206  VAL   A CG1 1 ? 
ATOM   32   C CG2 . VAL   A 1 9   ? 1.011   20.323  -8.705  1.000 9.637  0 206  VAL   A CG2 1 ? 
ATOM   33   N N   . LEU   A 1 10  ? 0.114   18.730  -4.263  1.000 9.402  0 207  LEU   A N   1 ? 
ATOM   34   C CA  . LEU   A 1 10  ? -0.544  17.875  -3.240  1.000 9.764  0 207  LEU   A CA  1 ? 
ATOM   35   C C   . LEU   A 1 10  ? -1.952  17.517  -3.726  1.000 9.895  0 207  LEU   A C   1 ? 
ATOM   36   O O   . LEU   A 1 10  ? -2.658  18.412  -4.234  1.000 10.000 0 207  LEU   A O   1 ? 
ATOM   37   C CB  . LEU   A 1 10  ? -0.582  18.620  -1.902  1.000 10.036 0 207  LEU   A CB  1 ? 
ATOM   38   C CG  . LEU   A 1 10  ? 0.769   19.117  -1.384  1.000 10.406 0 207  LEU   A CG  1 ? 
ATOM   39   C CD1 . LEU   A 1 10  ? 0.604   19.852  -0.062  1.000 10.738 0 207  LEU   A CD1 1 ? 
ATOM   40   C CD2 . LEU   A 1 10  ? 1.762   17.972  -1.238  1.000 10.492 0 207  LEU   A CD2 1 ? 
ATOM   41   N N   . GLN   A 1 11  ? -2.334  16.248  -3.580  1.000 10.145 0 208  GLN   A N   1 ? 
ATOM   42   C CA  . GLN   A 1 11  ? -3.582  15.678  -4.158  1.000 10.696 0 208  GLN   A CA  1 ? 
ATOM   43   C C   . GLN   A 1 11  ? -4.515  15.132  -3.075  1.000 10.662 0 208  GLN   A C   1 ? 
ATOM   44   O O   . GLN   A 1 11  ? -5.739  15.219  -3.260  1.000 10.268 0 208  GLN   A O   1 ? 
ATOM   45   C CB  . GLN   A 1 11  ? -3.247  14.529  -5.105  1.000 11.433 0 208  GLN   A CB  1 ? 
ATOM   46   C CG  . GLN   A 1 11  ? -2.474  14.962  -6.336  1.000 12.134 0 208  GLN   A CG  1 ? 
ATOM   47   C CD  . GLN   A 1 11  ? -1.837  13.763  -6.990  1.000 13.208 0 208  GLN   A CD  1 ? 
ATOM   48   O OE1 . GLN   A 1 11  ? -0.915  13.157  -6.445  1.000 14.998 0 208  GLN   A OE1 1 ? 
ATOM   49   N NE2 . GLN   A 1 11  ? -2.345  13.396  -8.152  1.000 13.750 0 208  GLN   A NE2 1 ? 
ATOM   50   N N   . GLU   A 1 12  ? -3.970  14.521  -2.023  1.000 10.918 0 209  GLU   A N   1 ? 
ATOM   51   C CA  . GLU   A 1 12  ? -4.763  13.695  -1.078  1.000 11.729 0 209  GLU   A CA  1 ? 
ATOM   52   C C   . GLU   A 1 12  ? -4.050  13.619  0.273   1.000 11.659 0 209  GLU   A C   1 ? 
ATOM   53   O O   . GLU   A 1 12  ? -2.839  13.339  0.293   1.000 11.062 0 209  GLU   A O   1 ? 
ATOM   54   C CB  . GLU   A 1 12  ? -4.962  12.304  -1.679  1.000 12.674 0 209  GLU   A CB  1 ? 
ATOM   55   C CG  . GLU   A 1 12  ? -5.771  11.367  -0.806  1.000 13.689 0 209  GLU   A CG  1 ? 
ATOM   56   C CD  . GLU   A 1 12  ? -5.989  9.993   -1.409  1.000 14.694 0 209  GLU   A CD  1 ? 
ATOM   57   O OE1 . GLU   A 1 12  ? -6.798  9.233   -0.844  1.000 16.782 0 209  GLU   A OE1 1 ? 
ATOM   58   O OE2 . GLU   A 1 12  ? -5.348  9.683   -2.432  1.000 16.038 0 209  GLU   A OE2 1 ? 
ATOM   59   N N   . SER   A 1 13  ? -4.789  13.858  1.356   1.000 12.121 0 210  SER   A N   1 ? 
ATOM   60   C CA  . SER   A 1 13  ? -4.337  13.650  2.756   1.000 13.204 0 210  SER   A CA  1 ? 
ATOM   61   C C   . SER   A 1 13  ? -4.221  12.143  3.012   1.000 13.754 0 210  SER   A C   1 ? 
ATOM   62   O O   . SER   A 1 13  ? -5.235  11.449  2.841   1.000 14.114 0 210  SER   A O   1 ? 
ATOM   63   C CB  . SER   A 1 13  ? -5.289  14.309  3.720   1.000 13.607 0 210  SER   A CB  1 ? 
ATOM   64   O OG  . SER   A 1 13  ? -4.938  14.018  5.065   1.000 14.714 0 210  SER   A OG  1 ? 
ATOM   65   N N   . ILE   A 1 14  ? -3.034  11.645  3.373   1.000 14.360 0 211  ILE   A N   1 ? 
ATOM   66   C CA  . ILE   A 1 14  ? -2.800  10.187  3.619   1.000 15.321 0 211  ILE   A CA  1 ? 
ATOM   67   C C   . ILE   A 1 14  ? -2.263  9.982   5.044   1.000 16.822 0 211  ILE   A C   1 ? 
ATOM   68   O O   . ILE   A 1 14  ? -1.497  9.020   5.247   1.000 17.870 0 211  ILE   A O   1 ? 
ATOM   69   C CB  . ILE   A 1 14  ? -1.896  9.567   2.528   1.000 14.855 0 211  ILE   A CB  1 ? 
ATOM   70   C CG1 . ILE   A 1 14  ? -0.510  10.217  2.466   1.000 14.714 0 211  ILE   A CG1 1 ? 
ATOM   71   C CG2 . ILE   A 1 14  ? -2.597  9.604   1.177   1.000 14.808 0 211  ILE   A CG2 1 ? 
ATOM   72   C CD1 . ILE   A 1 14  ? 0.441   9.568   1.484   1.000 14.576 0 211  ILE   A CD1 1 ? 
ATOM   73   N N   . GLY   A 1 15  ? -2.685  10.827  5.996   1.000 18.386 0 212  GLY   A N   1 ? 
ATOM   74   C CA  . GLY   A 1 15  ? -2.524  10.598  7.448   1.000 19.354 0 212  GLY   A CA  1 ? 
ATOM   75   C C   . GLY   A 1 15  ? -1.580  11.589  8.111   1.000 20.545 0 212  GLY   A C   1 ? 
ATOM   76   O O   . GLY   A 1 15  ? -1.098  12.494  7.404   1.000 21.605 0 212  GLY   A O   1 ? 
ATOM   77   N N   . PHE   A 1 19  ? 4.456   14.391  14.571  1.000 23.689 0 216  PHE   A N   1 ? 
ATOM   78   C CA  . PHE   A 1 19  ? 4.789   15.743  14.045  1.000 23.518 0 216  PHE   A CA  1 ? 
ATOM   79   C C   . PHE   A 1 19  ? 4.501   15.787  12.540  1.000 22.569 0 216  PHE   A C   1 ? 
ATOM   80   O O   . PHE   A 1 19  ? 4.848   14.826  11.832  1.000 23.115 0 216  PHE   A O   1 ? 
ATOM   81   C CB  . PHE   A 1 19  ? 6.249   16.101  14.336  1.000 24.517 0 216  PHE   A CB  1 ? 
ATOM   82   C CG  . PHE   A 1 19  ? 6.608   16.122  15.800  1.000 25.535 0 216  PHE   A CG  1 ? 
ATOM   83   C CD1 . PHE   A 1 19  ? 6.283   17.210  16.596  1.000 26.318 0 216  PHE   A CD1 1 ? 
ATOM   84   C CD2 . PHE   A 1 19  ? 7.270   15.053  16.384  1.000 26.341 0 216  PHE   A CD2 1 ? 
ATOM   85   C CE1 . PHE   A 1 19  ? 6.610   17.227  17.944  1.000 26.678 0 216  PHE   A CE1 1 ? 
ATOM   86   C CE2 . PHE   A 1 19  ? 7.598   15.071  17.732  1.000 26.652 0 216  PHE   A CE2 1 ? 
ATOM   87   C CZ  . PHE   A 1 19  ? 7.267   16.158  18.509  1.000 26.919 0 216  PHE   A CZ  1 ? 
ATOM   88   N N   . GLY   A 1 20  ? 3.876   16.872  12.079  1.000 21.512 0 217  GLY   A N   1 ? 
ATOM   89   C CA  . GLY   A 1 20  ? 3.577   17.114  10.655  1.000 20.094 0 217  GLY   A CA  1 ? 
ATOM   90   C C   . GLY   A 1 20  ? 2.390   16.302  10.163  1.000 18.955 0 217  GLY   A C   1 ? 
ATOM   91   O O   . GLY   A 1 20  ? 1.743   15.626  10.985  1.000 19.842 0 217  GLY   A O   1 ? 
ATOM   92   N N   . GLU   A 1 21  ? 2.120   16.376  8.856   1.000 16.929 0 218  GLU   A N   1 ? 
ATOM   93   C CA  . GLU   A 1 21  ? 0.975   15.721  8.167   1.000 16.066 0 218  GLU   A CA  1 ? 
ATOM   94   C C   . GLU   A 1 21  ? 1.465   15.198  6.815   1.000 13.761 0 218  GLU   A C   1 ? 
ATOM   95   O O   . GLU   A 1 21  ? 2.343   15.848  6.214   1.000 12.957 0 218  GLU   A O   1 ? 
ATOM   96   C CB  . GLU   A 1 21  ? -0.181  16.706  7.981   1.000 17.659 0 218  GLU   A CB  1 ? 
ATOM   97   C CG  . GLU   A 1 21  ? 0.214   17.974  7.245   1.000 19.301 0 218  GLU   A CG  1 ? 
ATOM   98   C CD  . GLU   A 1 21  ? -0.893  19.000  7.069   1.000 20.796 0 218  GLU   A CD  1 ? 
ATOM   99   O OE1 . GLU   A 1 21  ? -0.778  19.828  6.141   1.000 22.438 0 218  GLU   A OE1 1 ? 
ATOM   100  O OE2 . GLU   A 1 21  ? -1.862  18.975  7.858   1.000 23.139 0 218  GLU   A OE2 1 ? 
ATOM   101  N N   . VAL   A 1 22  ? 0.923   14.071  6.354   1.000 11.893 0 219  VAL   A N   1 ? 
ATOM   102  C CA  . VAL   A 1 22  ? 1.429   13.362  5.144   1.000 11.029 0 219  VAL   A CA  1 ? 
ATOM   103  C C   . VAL   A 1 22  ? 0.409   13.491  4.010   1.000 10.443 0 219  VAL   A C   1 ? 
ATOM   104  O O   . VAL   A 1 22  ? -0.808  13.357  4.260   1.000 10.124 0 219  VAL   A O   1 ? 
ATOM   105  C CB  . VAL   A 1 22  ? 1.778   11.894  5.440   1.000 11.040 0 219  VAL   A CB  1 ? 
ATOM   106  C CG1 . VAL   A 1 22  ? 2.479   11.242  4.260   1.000 11.043 0 219  VAL   A CG1 1 ? 
ATOM   107  C CG2 . VAL   A 1 22  ? 2.634   11.775  6.691   1.000 11.042 0 219  VAL   A CG2 1 ? 
ATOM   108  N N   . TRP   A 1 23  ? 0.921   13.745  2.807   1.000 9.830  0 220  TRP   A N   1 ? 
ATOM   109  C CA  . TRP   A 1 23  ? 0.137   13.972  1.568   1.000 10.030 0 220  TRP   A CA  1 ? 
ATOM   110  C C   . TRP   A 1 23  ? 0.673   13.083  0.453   1.000 10.007 0 220  TRP   A C   1 ? 
ATOM   111  O O   . TRP   A 1 23  ? 1.903   12.900  0.362   1.000 9.752  0 220  TRP   A O   1 ? 
ATOM   112  C CB  . TRP   A 1 23  ? 0.209   15.443  1.152   1.000 10.249 0 220  TRP   A CB  1 ? 
ATOM   113  C CG  . TRP   A 1 23  ? -0.495  16.352  2.104   1.000 10.669 0 220  TRP   A CG  1 ? 
ATOM   114  C CD1 . TRP   A 1 23  ? -0.000  16.884  3.258   1.000 10.915 0 220  TRP   A CD1 1 ? 
ATOM   115  C CD2 . TRP   A 1 23  ? -1.844  16.829  1.982   1.000 10.953 0 220  TRP   A CD2 1 ? 
ATOM   116  N NE1 . TRP   A 1 23  ? -0.949  17.663  3.861   1.000 11.450 0 220  TRP   A NE1 1 ? 
ATOM   117  C CE2 . TRP   A 1 23  ? -2.091  17.645  3.105   1.000 11.351 0 220  TRP   A CE2 1 ? 
ATOM   118  C CE3 . TRP   A 1 23  ? -2.864  16.641  1.042   1.000 11.239 0 220  TRP   A CE3 1 ? 
ATOM   119  C CZ2 . TRP   A 1 23  ? -3.318  18.276  3.306   1.000 11.596 0 220  TRP   A CZ2 1 ? 
ATOM   120  C CZ3 . TRP   A 1 23  ? -4.074  17.267  1.244   1.000 11.370 0 220  TRP   A CZ3 1 ? 
ATOM   121  C CH2 . TRP   A 1 23  ? -4.294  18.074  2.358   1.000 11.670 0 220  TRP   A CH2 1 ? 
ATOM   122  N N   . ARG   A 1 24  ? -0.230  12.593  -0.389  1.000 10.226 0 221  ARG   A N   1 ? 
ATOM   123  C CA  . ARG   A 1 24  ? 0.110   12.061  -1.728  1.000 10.812 0 221  ARG   A CA  1 ? 
ATOM   124  C C   . ARG   A 1 24  ? 0.239   13.255  -2.674  1.000 10.935 0 221  ARG   A C   1 ? 
ATOM   125  O O   . ARG   A 1 24  ? -0.731  14.032  -2.787  1.000 11.067 0 221  ARG   A O   1 ? 
ATOM   126  C CB  . ARG   A 1 24  ? -0.966  11.080  -2.192  1.000 11.341 0 221  ARG   A CB  1 ? 
ATOM   127  C CG  . ARG   A 1 24  ? -0.719  10.494  -3.573  1.000 12.012 0 221  ARG   A CG  1 ? 
ATOM   128  C CD  . ARG   A 1 24  ? -1.726  9.407   -3.892  1.000 12.741 0 221  ARG   A CD  1 ? 
ATOM   129  N NE  . ARG   A 1 24  ? -3.097  9.888   -4.015  1.000 13.270 0 221  ARG   A NE  1 ? 
ATOM   130  C CZ  . ARG   A 1 24  ? -3.656  10.363  -5.128  1.000 13.833 0 221  ARG   A CZ  1 ? 
ATOM   131  N NH1 . ARG   A 1 24  ? -2.967  10.452  -6.255  1.000 14.203 0 221  ARG   A NH1 1 ? 
ATOM   132  N NH2 . ARG   A 1 24  ? -4.919  10.752  -5.103  1.000 14.183 0 221  ARG   A NH2 1 ? 
ATOM   133  N N   . GLY   A 1 25  ? 1.410   13.415  -3.282  1.000 10.950 0 222  GLY   A N   1 ? 
ATOM   134  C CA  . GLY   A 1 25  ? 1.701   14.506  -4.226  1.000 11.400 0 222  GLY   A CA  1 ? 
ATOM   135  C C   . GLY   A 1 25  ? 2.083   13.951  -5.578  1.000 11.623 0 222  GLY   A C   1 ? 
ATOM   136  O O   . GLY   A 1 25  ? 2.317   12.732  -5.677  1.000 11.102 0 222  GLY   A O   1 ? 
ATOM   137  N N   . LYS   A 1 26  ? 2.145   14.817  -6.585  1.000 12.520 0 223  LYS   A N   1 ? 
ATOM   138  C CA  . LYS   A 1 26  ? 2.630   14.473  -7.942  1.000 13.844 0 223  LYS   A CA  1 ? 
ATOM   139  C C   . LYS   A 1 26  ? 3.822   15.372  -8.266  1.000 13.991 0 223  LYS   A C   1 ? 
ATOM   140  O O   . LYS   A 1 26  ? 3.714   16.599  -8.081  1.000 13.141 0 223  LYS   A O   1 ? 
ATOM   141  C CB  . LYS   A 1 26  ? 1.510   14.612  -8.980  1.000 15.275 0 223  LYS   A CB  1 ? 
ATOM   142  C CG  . LYS   A 1 26  ? 0.871   13.302  -9.427  1.000 16.825 0 223  LYS   A CG  1 ? 
ATOM   143  C CD  . LYS   A 1 26  ? -0.100  13.471  -10.581 1.000 17.622 0 223  LYS   A CD  1 ? 
ATOM   144  C CE  . LYS   A 1 26  ? -0.479  12.175  -11.269 1.000 18.724 0 223  LYS   A CE  1 ? 
ATOM   145  N NZ  . LYS   A 1 26  ? -1.566  11.456  -10.564 1.000 19.708 0 223  LYS   A NZ  1 ? 
ATOM   146  N N   . TRP   A 1 27  ? 4.928   14.744  -8.665  1.000 14.927 0 224  TRP   A N   1 ? 
ATOM   147  C CA  A TRP   A 1 27  ? 6.127   15.426  -9.213  0.500 15.636 0 224  TRP   A CA  1 ? 
ATOM   148  C CA  B TRP   A 1 27  ? 6.159   15.391  -9.191  0.500 15.639 0 224  TRP   A CA  1 ? 
ATOM   149  C C   . TRP   A 1 27  ? 6.298   14.996  -10.669 1.000 16.496 0 224  TRP   A C   1 ? 
ATOM   150  O O   . TRP   A 1 27  ? 6.698   13.840  -10.908 1.000 17.149 0 224  TRP   A O   1 ? 
ATOM   151  C CB  A TRP   A 1 27  ? 7.393   15.133  -8.406  0.500 15.546 0 224  TRP   A CB  1 ? 
ATOM   152  C CB  B TRP   A 1 27  ? 7.349   14.942  -8.324  0.500 15.554 0 224  TRP   A CB  1 ? 
ATOM   153  C CG  A TRP   A 1 27  ? 8.597   15.733  -9.060  0.500 15.529 0 224  TRP   A CG  1 ? 
ATOM   154  C CG  B TRP   A 1 27  ? 8.615   15.738  -8.433  0.500 15.557 0 224  TRP   A CG  1 ? 
ATOM   155  C CD1 A TRP   A 1 27  ? 8.902   17.060  -9.146  0.500 15.577 0 224  TRP   A CD1 1 ? 
ATOM   156  C CD1 B TRP   A 1 27  ? 8.755   17.044  -8.804  0.500 15.591 0 224  TRP   A CD1 1 ? 
ATOM   157  C CD2 A TRP   A 1 27  ? 9.626   15.036  -9.784  0.500 15.539 0 224  TRP   A CD2 1 ? 
ATOM   158  C CD2 B TRP   A 1 27  ? 9.938   15.277  -8.098  0.500 15.429 0 224  TRP   A CD2 1 ? 
ATOM   159  N NE1 A TRP   A 1 27  ? 10.062  17.236  -9.849  0.500 15.629 0 224  TRP   A NE1 1 ? 
ATOM   160  N NE1 B TRP   A 1 27  ? 10.073  17.416  -8.749  0.500 15.646 0 224  TRP   A NE1 1 ? 
ATOM   161  C CE2 A TRP   A 1 27  ? 10.531  16.013  -10.251 0.500 15.648 0 224  TRP   A CE2 1 ? 
ATOM   162  C CE2 B TRP   A 1 27  ? 10.823  16.353  -8.320  0.500 15.434 0 224  TRP   A CE2 1 ? 
ATOM   163  C CE3 A TRP   A 1 27  ? 9.879   13.690  -10.069 0.500 15.690 0 224  TRP   A CE3 1 ? 
ATOM   164  C CE3 B TRP   A 1 27  ? 10.462  14.058  -7.650  0.500 15.351 0 224  TRP   A CE3 1 ? 
ATOM   165  C CZ2 A TRP   A 1 27  ? 11.669  15.681  -10.983 0.500 15.532 0 224  TRP   A CZ2 1 ? 
ATOM   166  C CZ2 B TRP   A 1 27  ? 12.196  16.244  -8.107  0.500 15.423 0 224  TRP   A CZ2 1 ? 
ATOM   167  C CZ3 A TRP   A 1 27  ? 11.004  13.364  -10.792 0.500 15.558 0 224  TRP   A CZ3 1 ? 
ATOM   168  C CZ3 B TRP   A 1 27  ? 11.819  13.951  -7.442  0.500 15.367 0 224  TRP   A CZ3 1 ? 
ATOM   169  C CH2 A TRP   A 1 27  ? 11.884  14.347  -11.243 0.500 15.597 0 224  TRP   A CH2 1 ? 
ATOM   170  C CH2 B TRP   A 1 27  ? 12.673  15.031  -7.669  0.500 15.313 0 224  TRP   A CH2 1 ? 
ATOM   171  N N   . ARG   A 1 28  ? 5.949   15.895  -11.597 1.000 17.717 0 225  ARG   A N   1 ? 
ATOM   172  C CA  . ARG   A 1 28  ? 5.922   15.627  -13.063 1.000 19.009 0 225  ARG   A CA  1 ? 
ATOM   173  C C   . ARG   A 1 28  ? 5.027   14.413  -13.350 1.000 18.978 0 225  ARG   A C   1 ? 
ATOM   174  O O   . ARG   A 1 28  ? 5.374   13.613  -14.246 1.000 19.786 0 225  ARG   A O   1 ? 
ATOM   175  C CB  . ARG   A 1 28  ? 7.336   15.383  -13.595 1.000 20.107 0 225  ARG   A CB  1 ? 
ATOM   176  C CG  . ARG   A 1 28  ? 8.309   16.520  -13.328 1.000 21.197 0 225  ARG   A CG  1 ? 
ATOM   177  C CD  . ARG   A 1 28  ? 9.608   16.293  -14.074 1.000 22.376 0 225  ARG   A CD  1 ? 
ATOM   178  N NE  . ARG   A 1 28  ? 10.616  17.293  -13.753 1.000 23.339 0 225  ARG   A NE  1 ? 
ATOM   179  C CZ  . ARG   A 1 28  ? 11.899  17.220  -14.101 1.000 24.134 0 225  ARG   A CZ  1 ? 
ATOM   180  N NH1 . ARG   A 1 28  ? 12.355  16.182  -14.785 1.000 24.692 0 225  ARG   A NH1 1 ? 
ATOM   181  N NH2 . ARG   A 1 28  ? 12.730  18.188  -13.753 1.000 25.033 0 225  ARG   A NH2 1 ? 
ATOM   182  N N   . GLY   A 1 29  ? 3.924   14.270  -12.612 1.000 18.727 0 226  GLY   A N   1 ? 
ATOM   183  C CA  . GLY   A 1 29  ? 2.936   13.196  -12.816 1.000 18.381 0 226  GLY   A CA  1 ? 
ATOM   184  C C   . GLY   A 1 29  ? 3.289   11.920  -12.068 1.000 17.811 0 226  GLY   A C   1 ? 
ATOM   185  O O   . GLY   A 1 29  ? 2.465   10.992  -12.113 1.000 18.623 0 226  GLY   A O   1 ? 
ATOM   186  N N   . GLU   A 1 30  ? 4.461   11.859  -11.419 1.000 17.568 0 227  GLU   A N   1 ? 
ATOM   187  C CA  . GLU   A 1 30  ? 4.901   10.698  -10.594 1.000 17.333 0 227  GLU   A CA  1 ? 
ATOM   188  C C   . GLU   A 1 30  ? 4.430   10.910  -9.152  1.000 16.243 0 227  GLU   A C   1 ? 
ATOM   189  O O   . GLU   A 1 30  ? 4.696   11.996  -8.591  1.000 15.429 0 227  GLU   A O   1 ? 
ATOM   190  C CB  . GLU   A 1 30  ? 6.421   10.513  -10.629 1.000 17.974 0 227  GLU   A CB  1 ? 
ATOM   191  C CG  . GLU   A 1 30  ? 6.900   9.300   -9.842  1.000 18.737 0 227  GLU   A CG  1 ? 
ATOM   192  C CD  . GLU   A 1 30  ? 8.389   9.001   -9.916  1.000 19.454 0 227  GLU   A CD  1 ? 
ATOM   193  O OE1 . GLU   A 1 30  ? 8.770   7.843   -9.643  1.000 20.420 0 227  GLU   A OE1 1 ? 
ATOM   194  O OE2 . GLU   A 1 30  ? 9.168   9.921   -10.237 1.000 20.413 0 227  GLU   A OE2 1 ? 
ATOM   195  N N   . GLU   A 1 31  ? 3.772   9.904   -8.571  1.000 15.322 0 228  GLU   A N   1 ? 
ATOM   196  C CA  . GLU   A 1 31  ? 3.319   9.935   -7.157  1.000 14.726 0 228  GLU   A CA  1 ? 
ATOM   197  C C   . GLU   A 1 31  ? 4.550   9.997   -6.246  1.000 13.054 0 228  GLU   A C   1 ? 
ATOM   198  O O   . GLU   A 1 31  ? 5.509   9.235   -6.477  1.000 12.845 0 228  GLU   A O   1 ? 
ATOM   199  C CB  . GLU   A 1 31  ? 2.466   8.714   -6.805  1.000 16.073 0 228  GLU   A CB  1 ? 
ATOM   200  C CG  . GLU   A 1 31  ? 1.213   8.559   -7.649  1.000 17.760 0 228  GLU   A CG  1 ? 
ATOM   201  C CD  . GLU   A 1 31  ? 0.376   9.815   -7.805  1.000 19.288 0 228  GLU   A CD  1 ? 
ATOM   202  O OE1 . GLU   A 1 31  ? -0.153  10.308  -6.789  1.000 20.560 0 228  GLU   A OE1 1 ? 
ATOM   203  O OE2 . GLU   A 1 31  ? 0.262   10.301  -8.948  1.000 22.299 0 228  GLU   A OE2 1 ? 
ATOM   204  N N   . VAL   A 1 32  ? 4.525   10.907  -5.274  1.000 11.185 0 229  VAL   A N   1 ? 
ATOM   205  C CA  . VAL   A 1 32  ? 5.503   10.986  -4.150  1.000 10.295 0 229  VAL   A CA  1 ? 
ATOM   206  C C   . VAL   A 1 32  ? 4.692   11.130  -2.863  1.000 9.480  0 229  VAL   A C   1 ? 
ATOM   207  O O   . VAL   A 1 32  ? 3.504   11.493  -2.940  1.000 9.182  0 229  VAL   A O   1 ? 
ATOM   208  C CB  . VAL   A 1 32  ? 6.501   12.146  -4.331  1.000 10.362 0 229  VAL   A CB  1 ? 
ATOM   209  C CG1 . VAL   A 1 32  ? 7.423   11.896  -5.515  1.000 10.476 0 229  VAL   A CG1 1 ? 
ATOM   210  C CG2 . VAL   A 1 32  ? 5.803   13.493  -4.469  1.000 10.298 0 229  VAL   A CG2 1 ? 
ATOM   211  N N   . ALA   A 1 33  ? 5.307   10.840  -1.720  1.000 8.746  0 230  ALA   A N   1 ? 
ATOM   212  C CA  . ALA   A 1 33  ? 4.734   11.147  -0.393  1.000 8.448  0 230  ALA   A CA  1 ? 
ATOM   213  C C   . ALA   A 1 33  ? 5.452   12.373  0.170   1.000 8.324  0 230  ALA   A C   1 ? 
ATOM   214  O O   . ALA   A 1 33  ? 6.682   12.473  0.026   1.000 8.107  0 230  ALA   A O   1 ? 
ATOM   215  C CB  . ALA   A 1 33  ? 4.832   9.955   0.525   1.000 8.436  0 230  ALA   A CB  1 ? 
ATOM   216  N N   . VAL   A 1 34  ? 4.695   13.290  0.766   1.000 8.232  0 231  VAL   A N   1 ? 
ATOM   217  C CA  . VAL   A 1 34  ? 5.245   14.539  1.358   1.000 8.462  0 231  VAL   A CA  1 ? 
ATOM   218  C C   . VAL   A 1 34  ? 4.784   14.607  2.810   1.000 8.601  0 231  VAL   A C   1 ? 
ATOM   219  O O   . VAL   A 1 34  ? 3.566   14.604  3.036   1.000 8.964  0 231  VAL   A O   1 ? 
ATOM   220  C CB  . VAL   A 1 34  ? 4.800   15.787  0.573   1.000 8.519  0 231  VAL   A CB  1 ? 
ATOM   221  C CG1 . VAL   A 1 34  ? 5.421   17.048  1.147   1.000 8.738  0 231  VAL   A CG1 1 ? 
ATOM   222  C CG2 . VAL   A 1 34  ? 5.108   15.665  -0.913  1.000 8.571  0 231  VAL   A CG2 1 ? 
ATOM   223  N N   . LYS   A 1 35  ? 5.722   14.658  3.754   1.000 8.804  0 232  LYS   A N   1 ? 
ATOM   224  C CA  . LYS   A 1 35  ? 5.406   15.001  5.160   1.000 9.156  0 232  LYS   A CA  1 ? 
ATOM   225  C C   . LYS   A 1 35  ? 5.696   16.487  5.352   1.000 9.206  0 232  LYS   A C   1 ? 
ATOM   226  O O   . LYS   A 1 35  ? 6.836   16.911  5.083   1.000 9.122  0 232  LYS   A O   1 ? 
ATOM   227  C CB  . LYS   A 1 35  ? 6.184   14.134  6.149   1.000 9.723  0 232  LYS   A CB  1 ? 
ATOM   228  C CG  . LYS   A 1 35  ? 5.769   14.357  7.595   1.000 10.349 0 232  LYS   A CG  1 ? 
ATOM   229  C CD  . LYS   A 1 35  ? 5.962   13.154  8.474   1.000 11.125 0 232  LYS   A CD  1 ? 
ATOM   230  C CE  . LYS   A 1 35  ? 7.419   12.805  8.643   1.000 11.377 0 232  LYS   A CE  1 ? 
ATOM   231  N NZ  . LYS   A 1 35  ? 7.644   12.051  9.899   1.000 11.568 0 232  LYS   A NZ  1 ? 
ATOM   232  N N   . ILE   A 1 36  ? 4.680   17.244  5.766   1.000 9.308  0 233  ILE   A N   1 ? 
ATOM   233  C CA  . ILE   A 1 36  ? 4.746   18.724  5.901   1.000 9.749  0 233  ILE   A CA  1 ? 
ATOM   234  C C   . ILE   A 1 36  ? 4.738   19.084  7.386   1.000 9.871  0 233  ILE   A C   1 ? 
ATOM   235  O O   . ILE   A 1 36  ? 3.848   18.601  8.114   1.000 10.116 0 233  ILE   A O   1 ? 
ATOM   236  C CB  . ILE   A 1 36  ? 3.600   19.404  5.131   1.000 10.091 0 233  ILE   A CB  1 ? 
ATOM   237  C CG1 . ILE   A 1 36  ? 3.641   19.016  3.650   1.000 10.414 0 233  ILE   A CG1 1 ? 
ATOM   238  C CG2 . ILE   A 1 36  ? 3.648   20.911  5.337   1.000 10.309 0 233  ILE   A CG2 1 ? 
ATOM   239  C CD1 . ILE   A 1 36  ? 2.561   19.640  2.804   1.000 10.657 0 233  ILE   A CD1 1 ? 
ATOM   240  N N   . PHE   A 1 37  ? 5.706   19.907  7.790   1.000 9.802  0 234  PHE   A N   1 ? 
ATOM   241  C CA  . PHE   A 1 37  ? 5.866   20.463  9.156   1.000 10.128 0 234  PHE   A CA  1 ? 
ATOM   242  C C   . PHE   A 1 37  ? 5.646   21.977  9.102   1.000 10.632 0 234  PHE   A C   1 ? 
ATOM   243  O O   . PHE   A 1 37  ? 5.942   22.610  8.072   1.000 10.879 0 234  PHE   A O   1 ? 
ATOM   244  C CB  . PHE   A 1 37  ? 7.273   20.196  9.694   1.000 9.950  0 234  PHE   A CB  1 ? 
ATOM   245  C CG  . PHE   A 1 37  ? 7.716   18.755  9.764   1.000 9.880  0 234  PHE   A CG  1 ? 
ATOM   246  C CD1 . PHE   A 1 37  ? 8.076   18.060  8.618   1.000 9.739  0 234  PHE   A CD1 1 ? 
ATOM   247  C CD2 . PHE   A 1 37  ? 7.859   18.118  10.988  1.000 10.015 0 234  PHE   A CD2 1 ? 
ATOM   248  C CE1 . PHE   A 1 37  ? 8.530   16.750  8.693   1.000 9.797  0 234  PHE   A CE1 1 ? 
ATOM   249  C CE2 . PHE   A 1 37  ? 8.310   16.809  11.061  1.000 10.126 0 234  PHE   A CE2 1 ? 
ATOM   250  C CZ  . PHE   A 1 37  ? 8.648   16.129  9.914   1.000 10.016 0 234  PHE   A CZ  1 ? 
ATOM   251  N N   . SER   A 1 38  ? 5.175   22.555  10.206  1.000 11.141 0 235  SER   A N   1 ? 
ATOM   252  C CA  . SER   A 1 38  ? 5.074   24.023  10.393  1.000 11.650 0 235  SER   A CA  1 ? 
ATOM   253  C C   . SER   A 1 38  ? 6.432   24.575  10.838  1.000 11.893 0 235  SER   A C   1 ? 
ATOM   254  O O   . SER   A 1 38  ? 7.312   23.770  11.217  1.000 11.665 0 235  SER   A O   1 ? 
ATOM   255  C CB  . SER   A 1 38  ? 4.003   24.366  11.381  1.000 11.942 0 235  SER   A CB  1 ? 
ATOM   256  O OG  . SER   A 1 38  ? 4.431   24.038  12.688  1.000 12.055 0 235  SER   A OG  1 ? 
ATOM   257  N N   . SER   A 1 39  ? 6.578   25.901  10.806  1.000 12.531 0 236  SER   A N   1 ? 
ATOM   258  C CA  . SER   A 1 39  ? 7.791   26.648  11.232  1.000 12.882 0 236  SER   A CA  1 ? 
ATOM   259  C C   . SER   A 1 39  ? 8.180   26.259  12.662  1.000 12.495 0 236  SER   A C   1 ? 
ATOM   260  O O   . SER   A 1 39  ? 9.386   26.150  12.941  1.000 12.950 0 236  SER   A O   1 ? 
ATOM   261  C CB  . SER   A 1 39  ? 7.573   28.135  11.126  1.000 13.354 0 236  SER   A CB  1 ? 
ATOM   262  O OG  . SER   A 1 39  ? 6.474   28.548  11.927  1.000 14.351 0 236  SER   A OG  1 ? 
ATOM   263  N N   . ARG   A 1 40  ? 7.197   26.062  13.543  1.000 12.001 0 237  ARG   A N   1 ? 
ATOM   264  C CA  . ARG   A 1 40  ? 7.459   25.798  14.981  1.000 11.865 0 237  ARG   A CA  1 ? 
ATOM   265  C C   . ARG   A 1 40  ? 7.883   24.336  15.187  1.000 11.935 0 237  ARG   A C   1 ? 
ATOM   266  O O   . ARG   A 1 40  ? 8.294   24.005  16.311  1.000 12.149 0 237  ARG   A O   1 ? 
ATOM   267  C CB  . ARG   A 1 40  ? 6.250   26.202  15.829  1.000 11.686 0 237  ARG   A CB  1 ? 
ATOM   268  C CG  . ARG   A 1 40  ? 4.984   25.399  15.577  1.000 11.577 0 237  ARG   A CG  1 ? 
ATOM   269  C CD  . ARG   A 1 40  ? 3.970   25.717  16.655  1.000 11.427 0 237  ARG   A CD  1 ? 
ATOM   270  N NE  . ARG   A 1 40  ? 2.650   25.207  16.338  1.000 11.366 0 237  ARG   A NE  1 ? 
ATOM   271  C CZ  . ARG   A 1 40  ? 1.561   25.413  17.072  1.000 11.165 0 237  ARG   A CZ  1 ? 
ATOM   272  N NH1 . ARG   A 1 40  ? 1.623   26.144  18.174  1.000 11.051 0 237  ARG   A NH1 1 ? 
ATOM   273  N NH2 . ARG   A 1 40  ? 0.406   24.909  16.678  1.000 11.303 0 237  ARG   A NH2 1 ? 
ATOM   274  N N   . GLU   A 1 41  ? 7.826   23.502  14.144  1.000 11.777 0 238  GLU   A N   1 ? 
ATOM   275  C CA  . GLU   A 1 41  ? 8.260   22.079  14.181  1.000 12.056 0 238  GLU   A CA  1 ? 
ATOM   276  C C   . GLU   A 1 41  ? 9.623   21.925  13.490  1.000 11.502 0 238  GLU   A C   1 ? 
ATOM   277  O O   . GLU   A 1 41  ? 9.985   20.782  13.150  1.000 10.871 0 238  GLU   A O   1 ? 
ATOM   278  C CB  . GLU   A 1 41  ? 7.211   21.200  13.497  1.000 12.761 0 238  GLU   A CB  1 ? 
ATOM   279  C CG  . GLU   A 1 41  ? 5.855   21.207  14.177  1.000 13.723 0 238  GLU   A CG  1 ? 
ATOM   280  C CD  . GLU   A 1 41  ? 4.795   20.398  13.444  1.000 14.790 0 238  GLU   A CD  1 ? 
ATOM   281  O OE1 . GLU   A 1 41  ? 4.592   20.639  12.235  1.000 15.356 0 238  GLU   A OE1 1 ? 
ATOM   282  O OE2 . GLU   A 1 41  ? 4.184   19.517  14.079  1.000 17.067 0 238  GLU   A OE2 1 ? 
ATOM   283  N N   . GLU   A 1 42  ? 10.374  23.017  13.311  1.000 11.393 0 239  GLU   A N   1 ? 
ATOM   284  C CA  . GLU   A 1 42  ? 11.650  23.006  12.542  1.000 12.114 0 239  GLU   A CA  1 ? 
ATOM   285  C C   . GLU   A 1 42  ? 12.631  21.991  13.146  1.000 11.994 0 239  GLU   A C   1 ? 
ATOM   286  O O   . GLU   A 1 42  ? 13.329  21.320  12.369  1.000 11.092 0 239  GLU   A O   1 ? 
ATOM   287  C CB  . GLU   A 1 42  ? 12.274  24.402  12.473  1.000 13.197 0 239  GLU   A CB  1 ? 
ATOM   288  C CG  . GLU   A 1 42  ? 13.513  24.448  11.592  1.000 14.278 0 239  GLU   A CG  1 ? 
ATOM   289  C CD  . GLU   A 1 42  ? 14.141  25.815  11.375  1.000 15.959 0 239  GLU   A CD  1 ? 
ATOM   290  O OE1 . GLU   A 1 42  ? 13.551  26.822  11.806  1.000 17.656 0 239  GLU   A OE1 1 ? 
ATOM   291  O OE2 . GLU   A 1 42  ? 15.225  25.863  10.760  1.000 18.201 0 239  GLU   A OE2 1 ? 
ATOM   292  N N   . ARG   A 1 43  ? 12.703  21.877  14.473  1.000 12.181 0 240  ARG   A N   1 ? 
ATOM   293  C CA  . ARG   A 1 43  ? 13.697  20.985  15.131  1.000 12.910 0 240  ARG   A CA  1 ? 
ATOM   294  C C   . ARG   A 1 43  ? 13.405  19.527  14.758  1.000 11.869 0 240  ARG   A C   1 ? 
ATOM   295  O O   . ARG   A 1 43  ? 14.367  18.797  14.453  1.000 11.258 0 240  ARG   A O   1 ? 
ATOM   296  C CB  . ARG   A 1 43  ? 13.722  21.215  16.645  1.000 14.730 0 240  ARG   A CB  1 ? 
ATOM   297  C CG  . ARG   A 1 43  ? 14.476  22.470  17.064  1.000 16.716 0 240  ARG   A CG  1 ? 
ATOM   298  C CD  . ARG   A 1 43  ? 15.956  22.409  16.718  1.000 18.748 0 240  ARG   A CD  1 ? 
ATOM   299  N NE  . ARG   A 1 43  ? 16.244  22.830  15.349  1.000 20.858 0 240  ARG   A NE  1 ? 
ATOM   300  C CZ  . ARG   A 1 43  ? 17.361  22.553  14.675  1.000 21.870 0 240  ARG   A CZ  1 ? 
ATOM   301  N NH1 . ARG   A 1 43  ? 18.326  21.838  15.229  1.000 22.742 0 240  ARG   A NH1 1 ? 
ATOM   302  N NH2 . ARG   A 1 43  ? 17.506  22.994  13.436  1.000 22.829 0 240  ARG   A NH2 1 ? 
ATOM   303  N N   . SER   A 1 44  ? 12.134  19.119  14.745  1.000 11.030 0 241  SER   A N   1 ? 
ATOM   304  C CA  . SER   A 1 44  ? 11.712  17.738  14.398  1.000 10.683 0 241  SER   A CA  1 ? 
ATOM   305  C C   . SER   A 1 44  ? 11.985  17.475  12.913  1.000 9.545  0 241  SER   A C   1 ? 
ATOM   306  O O   . SER   A 1 44  ? 12.517  16.404  12.579  1.000 9.141  0 241  SER   A O   1 ? 
ATOM   307  C CB  . SER   A 1 44  ? 10.264  17.505  14.742  1.000 11.131 0 241  SER   A CB  1 ? 
ATOM   308  O OG  . SER   A 1 44  ? 10.079  17.502  16.150  1.000 12.731 0 241  SER   A OG  1 ? 
ATOM   309  N N   . TRP   A 1 45  ? 11.629  18.426  12.049  1.000 8.676  0 242  TRP   A N   1 ? 
ATOM   310  C CA  . TRP   A 1 45  ? 11.873  18.347  10.586  1.000 8.179  0 242  TRP   A CA  1 ? 
ATOM   311  C C   . TRP   A 1 45  ? 13.376  18.222  10.319  1.000 7.997  0 242  TRP   A C   1 ? 
ATOM   312  O O   . TRP   A 1 45  ? 13.778  17.314  9.566   1.000 7.832  0 242  TRP   A O   1 ? 
ATOM   313  C CB  . TRP   A 1 45  ? 11.281  19.572  9.888   1.000 8.008  0 242  TRP   A CB  1 ? 
ATOM   314  C CG  . TRP   A 1 45  ? 11.751  19.761  8.481   1.000 7.882  0 242  TRP   A CG  1 ? 
ATOM   315  C CD1 . TRP   A 1 45  ? 11.272  19.144  7.364   1.000 7.913  0 242  TRP   A CD1 1 ? 
ATOM   316  C CD2 . TRP   A 1 45  ? 12.791  20.648  8.037   1.000 7.865  0 242  TRP   A CD2 1 ? 
ATOM   317  N NE1 . TRP   A 1 45  ? 11.945  19.582  6.257   1.000 7.887  0 242  TRP   A NE1 1 ? 
ATOM   318  C CE2 . TRP   A 1 45  ? 12.878  20.508  6.636   1.000 7.943  0 242  TRP   A CE2 1 ? 
ATOM   319  C CE3 . TRP   A 1 45  ? 13.649  21.545  8.684   1.000 7.903  0 242  TRP   A CE3 1 ? 
ATOM   320  C CZ2 . TRP   A 1 45  ? 13.791  21.233  5.874   1.000 7.960  0 242  TRP   A CZ2 1 ? 
ATOM   321  C CZ3 . TRP   A 1 45  ? 14.550  22.264  7.928   1.000 7.964  0 242  TRP   A CZ3 1 ? 
ATOM   322  C CH2 . TRP   A 1 45  ? 14.617  22.108  6.543   1.000 8.056  0 242  TRP   A CH2 1 ? 
ATOM   323  N N   . PHE   A 1 46  ? 14.179  19.101  10.917  1.000 8.112  0 243  PHE   A N   1 ? 
ATOM   324  C CA  . PHE   A 1 46  ? 15.645  19.131  10.690  1.000 8.307  0 243  PHE   A CA  1 ? 
ATOM   325  C C   . PHE   A 1 46  ? 16.259  17.799  11.131  1.000 8.169  0 243  PHE   A C   1 ? 
ATOM   326  O O   . PHE   A 1 46  ? 17.083  17.223  10.399  1.000 7.984  0 243  PHE   A O   1 ? 
ATOM   327  C CB  . PHE   A 1 46  ? 16.306  20.297  11.421  1.000 8.719  0 243  PHE   A CB  1 ? 
ATOM   328  C CG  . PHE   A 1 46  ? 17.789  20.357  11.168  1.000 9.229  0 243  PHE   A CG  1 ? 
ATOM   329  C CD1 . PHE   A 1 46  ? 18.280  20.999  10.044  1.000 9.700  0 243  PHE   A CD1 1 ? 
ATOM   330  C CD2 . PHE   A 1 46  ? 18.680  19.714  12.010  1.000 9.752  0 243  PHE   A CD2 1 ? 
ATOM   331  C CE1 . PHE   A 1 46  ? 19.641  21.033  9.790   1.000 9.918  0 243  PHE   A CE1 1 ? 
ATOM   332  C CE2 . PHE   A 1 46  ? 20.042  19.749  11.755  1.000 9.827  0 243  PHE   A CE2 1 ? 
ATOM   333  C CZ  . PHE   A 1 46  ? 20.518  20.410  10.645  1.000 9.935  0 243  PHE   A CZ  1 ? 
ATOM   334  N N   . ARG   A 1 47  ? 15.891  17.319  12.317  1.000 7.992  0 244  ARG   A N   1 ? 
ATOM   335  C CA  . ARG   A 1 47  ? 16.462  16.066  12.865  1.000 8.034  0 244  ARG   A CA  1 ? 
ATOM   336  C C   . ARG   A 1 47  ? 16.119  14.900  11.931  1.000 8.051  0 244  ARG   A C   1 ? 
ATOM   337  O O   . ARG   A 1 47  ? 17.002  14.074  11.664  1.000 7.755  0 244  ARG   A O   1 ? 
ATOM   338  C CB  . ARG   A 1 47  ? 15.964  15.829  14.291  1.000 8.116  0 244  ARG   A CB  1 ? 
ATOM   339  C CG  . ARG   A 1 47  ? 16.475  14.536  14.910  1.000 8.218  0 244  ARG   A CG  1 ? 
ATOM   340  C CD  . ARG   A 1 47  ? 17.989  14.409  14.898  1.000 8.350  0 244  ARG   A CD  1 ? 
ATOM   341  N NE  . ARG   A 1 47  ? 18.409  13.204  15.600  1.000 8.519  0 244  ARG   A NE  1 ? 
ATOM   342  C CZ  . ARG   A 1 47  ? 19.656  12.755  15.673  1.000 8.659  0 244  ARG   A CZ  1 ? 
ATOM   343  N NH1 . ARG   A 1 47  ? 20.650  13.404  15.085  1.000 8.861  0 244  ARG   A NH1 1 ? 
ATOM   344  N NH2 . ARG   A 1 47  ? 19.901  11.644  16.346  1.000 8.717  0 244  ARG   A NH2 1 ? 
ATOM   345  N N   . GLU   A 1 48  ? 14.880  14.814  11.449  1.000 7.954  0 245  GLU   A N   1 ? 
ATOM   346  C CA  . GLU   A 1 48  ? 14.486  13.696  10.557  1.000 8.155  0 245  GLU   A CA  1 ? 
ATOM   347  C C   . GLU   A 1 48  ? 15.232  13.823  9.221   1.000 7.881  0 245  GLU   A C   1 ? 
ATOM   348  O O   . GLU   A 1 48  ? 15.718  12.794  8.718   1.000 7.695  0 245  GLU   A O   1 ? 
ATOM   349  C CB  . GLU   A 1 48  ? 12.971  13.630  10.391  1.000 8.548  0 245  GLU   A CB  1 ? 
ATOM   350  C CG  . GLU   A 1 48  ? 12.543  12.361  9.685   1.000 9.013  0 245  GLU   A CG  1 ? 
ATOM   351  C CD  . GLU   A 1 48  ? 11.085  11.984  9.829   1.000 9.606  0 245  GLU   A CD  1 ? 
ATOM   352  O OE1 . GLU   A 1 48  ? 10.310  12.799  10.359  1.000 10.156 0 245  GLU   A OE1 1 ? 
ATOM   353  O OE2 . GLU   A 1 48  ? 10.737  10.868  9.403   1.000 10.394 0 245  GLU   A OE2 1 ? 
ATOM   354  N N   . ALA   A 1 49  ? 15.353  15.036  8.674   1.000 7.766  0 246  ALA   A N   1 ? 
ATOM   355  C CA  . ALA   A 1 49  ? 16.152  15.307  7.453   1.000 7.701  0 246  ALA   A CA  1 ? 
ATOM   356  C C   . ALA   A 1 49  ? 17.593  14.830  7.668   1.000 7.735  0 246  ALA   A C   1 ? 
ATOM   357  O O   . ALA   A 1 49  ? 18.152  14.173  6.773   1.000 7.841  0 246  ALA   A O   1 ? 
ATOM   358  C CB  . ALA   A 1 49  ? 16.119  16.775  7.117   1.000 7.806  0 246  ALA   A CB  1 ? 
ATOM   359  N N   . GLU   A 1 50  ? 18.164  15.148  8.828   1.000 7.829  0 247  GLU   A N   1 ? 
ATOM   360  C CA  . GLU   A 1 50  ? 19.545  14.755  9.209   1.000 7.997  0 247  GLU   A CA  1 ? 
ATOM   361  C C   . GLU   A 1 50  ? 19.680  13.226  9.186   1.000 7.744  0 247  GLU   A C   1 ? 
ATOM   362  O O   . GLU   A 1 50  ? 20.637  12.724  8.577   1.000 7.831  0 247  GLU   A O   1 ? 
ATOM   363  C CB  . GLU   A 1 50  ? 19.870  15.332  10.584  1.000 8.481  0 247  GLU   A CB  1 ? 
ATOM   364  C CG  . GLU   A 1 50  ? 21.255  14.979  11.084  1.000 9.064  0 247  GLU   A CG  1 ? 
ATOM   365  C CD  . GLU   A 1 50  ? 21.629  15.708  12.359  1.000 9.729  0 247  GLU   A CD  1 ? 
ATOM   366  O OE1 . GLU   A 1 50  ? 20.810  15.702  13.304  1.000 10.233 0 247  GLU   A OE1 1 ? 
ATOM   367  O OE2 . GLU   A 1 50  ? 22.728  16.295  12.390  1.000 11.015 0 247  GLU   A OE2 1 ? 
ATOM   368  N N   . ILE   A 1 51  ? 18.757  12.500  9.817   1.000 7.613  0 248  ILE   A N   1 ? 
ATOM   369  C CA  . ILE   A 1 51  ? 18.834  11.010  9.876   1.000 7.561  0 248  ILE   A CA  1 ? 
ATOM   370  C C   . ILE   A 1 51  ? 18.783  10.469  8.442   1.000 7.467  0 248  ILE   A C   1 ? 
ATOM   371  O O   . ILE   A 1 51  ? 19.620  9.632   8.089   1.000 7.085  0 248  ILE   A O   1 ? 
ATOM   372  C CB  . ILE   A 1 51  ? 17.729  10.410  10.769  1.000 7.711  0 248  ILE   A CB  1 ? 
ATOM   373  C CG1 . ILE   A 1 51  ? 17.835  10.891  12.220  1.000 7.858  0 248  ILE   A CG1 1 ? 
ATOM   374  C CG2 . ILE   A 1 51  ? 17.744  8.891   10.679  1.000 7.758  0 248  ILE   A CG2 1 ? 
ATOM   375  C CD1 . ILE   A 1 51  ? 19.109  10.491  12.926  1.000 8.040  0 248  ILE   A CD1 1 ? 
ATOM   376  N N   . TYR   A 1 52  ? 17.840  10.937  7.627   1.000 7.492  0 249  TYR   A N   1 ? 
ATOM   377  C CA  . TYR   A 1 52  ? 17.658  10.427  6.244   1.000 7.742  0 249  TYR   A CA  1 ? 
ATOM   378  C C   . TYR   A 1 52  ? 18.888  10.722  5.378   1.000 7.903  0 249  TYR   A C   1 ? 
ATOM   379  O O   . TYR   A 1 52  ? 19.121  9.972   4.421   1.000 8.174  0 249  TYR   A O   1 ? 
ATOM   380  C CB  . TYR   A 1 52  ? 16.383  10.990  5.617   1.000 7.913  0 249  TYR   A CB  1 ? 
ATOM   381  C CG  . TYR   A 1 52  ? 15.156  10.157  5.872   1.000 8.247  0 249  TYR   A CG  1 ? 
ATOM   382  C CD1 . TYR   A 1 52  ? 14.980  8.948   5.219   1.000 8.463  0 249  TYR   A CD1 1 ? 
ATOM   383  C CD2 . TYR   A 1 52  ? 14.173  10.570  6.754   1.000 8.466  0 249  TYR   A CD2 1 ? 
ATOM   384  C CE1 . TYR   A 1 52  ? 13.851  8.172   5.430   1.000 8.728  0 249  TYR   A CE1 1 ? 
ATOM   385  C CE2 . TYR   A 1 52  ? 13.039  9.805   6.978   1.000 8.706  0 249  TYR   A CE2 1 ? 
ATOM   386  C CZ  . TYR   A 1 52  ? 12.877  8.603   6.311   1.000 8.811  0 249  TYR   A CZ  1 ? 
ATOM   387  O OH  . TYR   A 1 52  ? 11.760  7.843   6.516   1.000 9.262  0 249  TYR   A OH  1 ? 
ATOM   388  N N   . GLN   A 1 53  ? 19.662  11.762  5.698   1.000 7.803  0 250  GLN   A N   1 ? 
ATOM   389  C CA  . GLN   A 1 53  ? 20.849  12.149  4.888   1.000 7.935  0 250  GLN   A CA  1 ? 
ATOM   390  C C   . GLN   A 1 53  ? 22.112  11.456  5.412   1.000 8.053  0 250  GLN   A C   1 ? 
ATOM   391  O O   . GLN   A 1 53  ? 23.189  11.737  4.877   1.000 8.538  0 250  GLN   A O   1 ? 
ATOM   392  C CB  . GLN   A 1 53  ? 20.977  13.668  4.853   1.000 7.950  0 250  GLN   A CB  1 ? 
ATOM   393  C CG  . GLN   A 1 53  ? 19.870  14.306  4.031   1.000 8.120  0 250  GLN   A CG  1 ? 
ATOM   394  C CD  . GLN   A 1 53  ? 19.952  15.810  4.027   1.000 8.312  0 250  GLN   A CD  1 ? 
ATOM   395  O OE1 . GLN   A 1 53  ? 21.001  16.391  3.753   1.000 8.588  0 250  GLN   A OE1 1 ? 
ATOM   396  N NE2 . GLN   A 1 53  ? 18.840  16.460  4.328   1.000 8.435  0 250  GLN   A NE2 1 ? 
ATOM   397  N N   . THR   A 1 54  ? 21.989  10.548  6.385   1.000 8.130  0 251  THR   A N   1 ? 
ATOM   398  C CA  . THR   A 1 54  ? 23.130  9.744   6.890   1.000 8.211  0 251  THR   A CA  1 ? 
ATOM   399  C C   . THR   A 1 54  ? 23.822  9.063   5.705   1.000 8.393  0 251  THR   A C   1 ? 
ATOM   400  O O   . THR   A 1 54  ? 23.132  8.468   4.864   1.000 8.476  0 251  THR   A O   1 ? 
ATOM   401  C CB  . THR   A 1 54  ? 22.686  8.713   7.932   1.000 8.172  0 251  THR   A CB  1 ? 
ATOM   402  O OG1 . THR   A 1 54  ? 22.071  9.401   9.019   1.000 8.136  0 251  THR   A OG1 1 ? 
ATOM   403  C CG2 . THR   A 1 54  ? 23.839  7.883   8.450   1.000 8.124  0 251  THR   A CG2 1 ? 
ATOM   404  N N   . VAL   A 1 55  ? 25.151  9.123   5.671   1.000 8.770  0 252  VAL   A N   1 ? 
ATOM   405  C CA  . VAL   A 1 55  ? 25.976  8.467   4.618   1.000 9.404  0 252  VAL   A CA  1 ? 
ATOM   406  C C   . VAL   A 1 55  ? 25.615  6.977   4.563   1.000 9.520  0 252  VAL   A C   1 ? 
ATOM   407  O O   . VAL   A 1 55  ? 25.511  6.334   5.634   1.000 9.123  0 252  VAL   A O   1 ? 
ATOM   408  C CB  . VAL   A 1 55  ? 27.474  8.709   4.880   1.000 9.974  0 252  VAL   A CB  1 ? 
ATOM   409  C CG1 . VAL   A 1 55  ? 28.369  7.830   4.024   1.000 10.315 0 252  VAL   A CG1 1 ? 
ATOM   410  C CG2 . VAL   A 1 55  ? 27.828  10.175  4.686   1.000 10.195 0 252  VAL   A CG2 1 ? 
ATOM   411  N N   . MET   A 1 56  ? 25.385  6.469   3.351   1.000 9.812  0 253  MET   A N   1 ? 
ATOM   412  C CA  . MET   A 1 56  ? 25.148  5.035   3.037   1.000 10.244 0 253  MET   A CA  1 ? 
ATOM   413  C C   . MET   A 1 56  ? 23.897  4.503   3.750   1.000 9.772  0 253  MET   A C   1 ? 
ATOM   414  O O   . MET   A 1 56  ? 23.819  3.287   3.983   1.000 9.765  0 253  MET   A O   1 ? 
ATOM   415  C CB  . MET   A 1 56  ? 26.367  4.191   3.419   1.000 11.297 0 253  MET   A CB  1 ? 
ATOM   416  C CG  . MET   A 1 56  ? 27.482  4.302   2.407   1.000 12.205 0 253  MET   A CG  1 ? 
ATOM   417  S SD  . MET   A 1 56  ? 28.794  3.099   2.683   1.000 14.806 0 253  MET   A SD  1 ? 
ATOM   418  C CE  . MET   A 1 56  ? 27.949  1.562   2.331   1.000 14.051 0 253  MET   A CE  1 ? 
ATOM   419  N N   . LEU   A 1 57  ? 22.912  5.357   4.030   1.000 9.464  0 254  LEU   A N   1 ? 
ATOM   420  C CA  . LEU   A 1 57  ? 21.649  4.896   4.666   1.000 9.529  0 254  LEU   A CA  1 ? 
ATOM   421  C C   . LEU   A 1 57  ? 20.783  4.125   3.659   1.000 9.399  0 254  LEU   A C   1 ? 
ATOM   422  O O   . LEU   A 1 57  ? 20.059  3.211   4.091   1.000 9.266  0 254  LEU   A O   1 ? 
ATOM   423  C CB  . LEU   A 1 57  ? 20.864  6.082   5.227   1.000 9.685  0 254  LEU   A CB  1 ? 
ATOM   424  C CG  . LEU   A 1 57  ? 19.538  5.707   5.892   1.000 9.786  0 254  LEU   A CG  1 ? 
ATOM   425  C CD1 . LEU   A 1 57  ? 19.758  4.810   7.103   1.000 9.978  0 254  LEU   A CD1 1 ? 
ATOM   426  C CD2 . LEU   A 1 57  ? 18.758  6.949   6.276   1.000 9.966  0 254  LEU   A CD2 1 ? 
ATOM   427  N N   . ARG   A 1 58  ? 20.794  4.498   2.377   1.000 9.328  0 255  ARG   A N   1 ? 
ATOM   428  C CA  . ARG   A 1 58  ? 19.795  3.982   1.404   1.000 9.523  0 255  ARG   A CA  1 ? 
ATOM   429  C C   . ARG   A 1 58  ? 19.830  2.451   1.384   1.000 9.503  0 255  ARG   A C   1 ? 
ATOM   430  O O   . ARG   A 1 58  ? 20.921  1.861   1.351   1.000 9.867  0 255  ARG   A O   1 ? 
ATOM   431  C CB  . ARG   A 1 58  ? 20.020  4.557   0.006   1.000 9.693  0 255  ARG   A CB  1 ? 
ATOM   432  C CG  . ARG   A 1 58  ? 19.605  6.013   -0.131  1.000 9.917  0 255  ARG   A CG  1 ? 
ATOM   433  C CD  . ARG   A 1 58  ? 19.712  6.473   -1.571  1.000 10.227 0 255  ARG   A CD  1 ? 
ATOM   434  N NE  . ARG   A 1 58  ? 18.590  6.015   -2.377  1.000 10.576 0 255  ARG   A NE  1 ? 
ATOM   435  C CZ  . ARG   A 1 58  ? 17.407  6.626   -2.458  1.000 10.966 0 255  ARG   A CZ  1 ? 
ATOM   436  N NH1 . ARG   A 1 58  ? 17.175  7.733   -1.773  1.000 11.084 0 255  ARG   A NH1 1 ? 
ATOM   437  N NH2 . ARG   A 1 58  ? 16.453  6.118   -3.221  1.000 11.558 0 255  ARG   A NH2 1 ? 
ATOM   438  N N   . HIS   A 1 59  ? 18.650  1.843   1.406   1.000 9.301  0 256  HIS   A N   1 ? 
ATOM   439  C CA  . HIS   A 1 59  ? 18.449  0.379   1.519   1.000 9.378  0 256  HIS   A CA  1 ? 
ATOM   440  C C   . HIS   A 1 59  ? 17.018  0.075   1.092   1.000 9.519  0 256  HIS   A C   1 ? 
ATOM   441  O O   . HIS   A 1 59  ? 16.148  0.910   1.371   1.000 9.198  0 256  HIS   A O   1 ? 
ATOM   442  C CB  . HIS   A 1 59  ? 18.739  -0.059  2.956   1.000 9.406  0 256  HIS   A CB  1 ? 
ATOM   443  C CG  . HIS   A 1 59  ? 18.733  -1.533  3.161   1.000 9.452  0 256  HIS   A CG  1 ? 
ATOM   444  N ND1 . HIS   A 1 59  ? 17.571  -2.252  3.337   1.000 9.470  0 256  HIS   A ND1 1 ? 
ATOM   445  C CD2 . HIS   A 1 59  ? 19.749  -2.417  3.249   1.000 9.601  0 256  HIS   A CD2 1 ? 
ATOM   446  C CE1 . HIS   A 1 59  ? 17.873  -3.523  3.522   1.000 9.488  0 256  HIS   A CE1 1 ? 
ATOM   447  N NE2 . HIS   A 1 59  ? 19.201  -3.647  3.467   1.000 9.599  0 256  HIS   A NE2 1 ? 
ATOM   448  N N   . GLU   A 1 60  ? 16.777  -1.074  0.463   1.000 9.914  0 257  GLU   A N   1 ? 
ATOM   449  C CA  A GLU   A 1 60  ? 15.442  -1.427  -0.093  0.500 10.101 0 257  GLU   A CA  1 ? 
ATOM   450  C CA  B GLU   A 1 60  ? 15.437  -1.397  -0.099  0.500 10.065 0 257  GLU   A CA  1 ? 
ATOM   451  C C   . GLU   A 1 60  ? 14.393  -1.454  1.027   1.000 9.749  0 257  GLU   A C   1 ? 
ATOM   452  O O   . GLU   A 1 60  ? 13.213  -1.285  0.715   1.000 9.812  0 257  GLU   A O   1 ? 
ATOM   453  C CB  A GLU   A 1 60  ? 15.492  -2.756  -0.854  0.500 10.787 0 257  GLU   A CB  1 ? 
ATOM   454  C CB  B GLU   A 1 60  ? 15.477  -2.674  -0.946  0.500 10.706 0 257  GLU   A CB  1 ? 
ATOM   455  C CG  A GLU   A 1 60  ? 15.895  -3.957  -0.019  0.500 11.315 0 257  GLU   A CG  1 ? 
ATOM   456  C CG  B GLU   A 1 60  ? 15.810  -3.947  -0.190  0.500 11.153 0 257  GLU   A CG  1 ? 
ATOM   457  C CD  A GLU   A 1 60  ? 15.863  -5.271  -0.783  0.500 11.859 0 257  GLU   A CD  1 ? 
ATOM   458  C CD  B GLU   A 1 60  ? 15.965  -5.167  -1.086  0.500 11.594 0 257  GLU   A CD  1 ? 
ATOM   459  O OE1 A GLU   A 1 60  ? 14.905  -5.480  -1.550  0.500 12.341 0 257  GLU   A OE1 1 ? 
ATOM   460  O OE1 B GLU   A 1 60  ? 16.336  -4.994  -2.262  0.500 12.249 0 257  GLU   A OE1 1 ? 
ATOM   461  O OE2 A GLU   A 1 60  ? 16.797  -6.079  -0.612  0.500 12.348 0 257  GLU   A OE2 1 ? 
ATOM   462  O OE2 B GLU   A 1 60  ? 15.701  -6.290  -0.609  0.500 12.046 0 257  GLU   A OE2 1 ? 
ATOM   463  N N   . ASN   A 1 61  ? 14.808  -1.641  2.286   1.000 9.170  0 258  ASN   A N   1 ? 
ATOM   464  C CA  . ASN   A 1 61  ? 13.854  -1.767  3.424   1.000 8.730  0 258  ASN   A CA  1 ? 
ATOM   465  C C   . ASN   A 1 61  ? 13.892  -0.531  4.333   1.000 8.267  0 258  ASN   A C   1 ? 
ATOM   466  O O   . ASN   A 1 61  ? 13.375  -0.619  5.467   1.000 7.960  0 258  ASN   A O   1 ? 
ATOM   467  C CB  . ASN   A 1 61  ? 14.095  -3.070  4.185   1.000 8.815  0 258  ASN   A CB  1 ? 
ATOM   468  C CG  . ASN   A 1 61  ? 14.082  -4.272  3.266   1.000 9.123  0 258  ASN   A CG  1 ? 
ATOM   469  O OD1 . ASN   A 1 61  ? 15.044  -5.033  3.234   1.000 9.779  0 258  ASN   A OD1 1 ? 
ATOM   470  N ND2 . ASN   A 1 61  ? 13.018  -4.428  2.498   1.000 9.223  0 258  ASN   A ND2 1 ? 
ATOM   471  N N   . ILE   A 1 62  ? 14.420  0.589   3.837   1.000 7.907  0 259  ILE   A N   1 ? 
ATOM   472  C CA  . ILE   A 1 62  ? 14.301  1.939   4.463   1.000 7.970  0 259  ILE   A CA  1 ? 
ATOM   473  C C   . ILE   A 1 62  ? 13.576  2.835   3.459   1.000 7.772  0 259  ILE   A C   1 ? 
ATOM   474  O O   . ILE   A 1 62  ? 13.958  2.821   2.273   1.000 7.548  0 259  ILE   A O   1 ? 
ATOM   475  C CB  . ILE   A 1 62  ? 15.681  2.511   4.846   1.000 8.276  0 259  ILE   A CB  1 ? 
ATOM   476  C CG1 . ILE   A 1 62  ? 16.472  1.565   5.753   1.000 8.690  0 259  ILE   A CG1 1 ? 
ATOM   477  C CG2 . ILE   A 1 62  ? 15.543  3.894   5.464   1.000 8.305  0 259  ILE   A CG2 1 ? 
ATOM   478  C CD1 . ILE   A 1 62  ? 15.833  1.295   7.080   1.000 8.975  0 259  ILE   A CD1 1 ? 
ATOM   479  N N   . LEU   A 1 63  ? 12.566  3.587   3.898   1.000 7.475  0 260  LEU   A N   1 ? 
ATOM   480  C CA  . LEU   A 1 63  ? 11.804  4.482   2.991   1.000 7.462  0 260  LEU   A CA  1 ? 
ATOM   481  C C   . LEU   A 1 63  ? 12.788  5.357   2.206   1.000 7.499  0 260  LEU   A C   1 ? 
ATOM   482  O O   . LEU   A 1 63  ? 13.687  5.950   2.825   1.000 7.289  0 260  LEU   A O   1 ? 
ATOM   483  C CB  . LEU   A 1 63  ? 10.820  5.336   3.794   1.000 7.400  0 260  LEU   A CB  1 ? 
ATOM   484  C CG  . LEU   A 1 63  ? 10.037  6.359   2.968   1.000 7.462  0 260  LEU   A CG  1 ? 
ATOM   485  C CD1 . LEU   A 1 63  ? 9.192   5.679   1.901   1.000 7.483  0 260  LEU   A CD1 1 ? 
ATOM   486  C CD2 . LEU   A 1 63  ? 9.166   7.223   3.865   1.000 7.485  0 260  LEU   A CD2 1 ? 
ATOM   487  N N   . GLY   A 1 64  ? 12.621  5.400   0.883   1.000 7.664  0 261  GLY   A N   1 ? 
ATOM   488  C CA  . GLY   A 1 64  ? 13.507  6.127   -0.046  1.000 7.849  0 261  GLY   A CA  1 ? 
ATOM   489  C C   . GLY   A 1 64  ? 13.345  7.632   0.074   1.000 8.097  0 261  GLY   A C   1 ? 
ATOM   490  O O   . GLY   A 1 64  ? 12.268  8.144   -0.267  1.000 8.078  0 261  GLY   A O   1 ? 
ATOM   491  N N   . PHE   A 1 65  ? 14.380  8.315   0.558   1.000 8.528  0 262  PHE   A N   1 ? 
ATOM   492  C CA  . PHE   A 1 65  ? 14.430  9.790   0.718   1.000 9.170  0 262  PHE   A CA  1 ? 
ATOM   493  C C   . PHE   A 1 65  ? 14.567  10.433  -0.665  1.000 9.390  0 262  PHE   A C   1 ? 
ATOM   494  O O   . PHE   A 1 65  ? 15.352  9.939   -1.489  1.000 10.222 0 262  PHE   A O   1 ? 
ATOM   495  C CB  . PHE   A 1 65  ? 15.591  10.162  1.645   1.000 9.432  0 262  PHE   A CB  1 ? 
ATOM   496  C CG  . PHE   A 1 65  ? 15.913  11.632  1.741   1.000 9.667  0 262  PHE   A CG  1 ? 
ATOM   497  C CD1 . PHE   A 1 65  ? 15.205  12.457  2.597   1.000 9.776  0 262  PHE   A CD1 1 ? 
ATOM   498  C CD2 . PHE   A 1 65  ? 16.945  12.186  0.997   1.000 10.076 0 262  PHE   A CD2 1 ? 
ATOM   499  C CE1 . PHE   A 1 65  ? 15.514  13.804  2.701   1.000 9.908  0 262  PHE   A CE1 1 ? 
ATOM   500  C CE2 . PHE   A 1 65  ? 17.246  13.536  1.093   1.000 10.279 0 262  PHE   A CE2 1 ? 
ATOM   501  C CZ  . PHE   A 1 65  ? 16.532  14.341  1.949   1.000 10.140 0 262  PHE   A CZ  1 ? 
ATOM   502  N N   . ILE   A 1 66  ? 13.808  11.496  -0.923  1.000 9.396  0 263  ILE   A N   1 ? 
ATOM   503  C CA  . ILE   A 1 66  ? 13.957  12.306  -2.167  1.000 9.632  0 263  ILE   A CA  1 ? 
ATOM   504  C C   . ILE   A 1 66  ? 14.539  13.674  -1.803  1.000 9.811  0 263  ILE   A C   1 ? 
ATOM   505  O O   . ILE   A 1 66  ? 15.534  14.072  -2.433  1.000 10.775 0 263  ILE   A O   1 ? 
ATOM   506  C CB  . ILE   A 1 66  ? 12.626  12.407  -2.934  1.000 9.623  0 263  ILE   A CB  1 ? 
ATOM   507  C CG1 . ILE   A 1 66  ? 12.213  11.035  -3.473  1.000 9.665  0 263  ILE   A CG1 1 ? 
ATOM   508  C CG2 . ILE   A 1 66  ? 12.710  13.460  -4.035  1.000 9.766  0 263  ILE   A CG2 1 ? 
ATOM   509  C CD1 . ILE   A 1 66  ? 10.850  10.996  -4.118  1.000 9.652  0 263  ILE   A CD1 1 ? 
ATOM   510  N N   . ALA   A 1 67  ? 13.956  14.385  -0.840  1.000 9.643  0 264  ALA   A N   1 ? 
ATOM   511  C CA  . ALA   A 1 67  ? 14.391  15.765  -0.530  1.000 9.601  0 264  ALA   A CA  1 ? 
ATOM   512  C C   . ALA   A 1 67  ? 13.864  16.234  0.825   1.000 9.491  0 264  ALA   A C   1 ? 
ATOM   513  O O   . ALA   A 1 67  ? 12.784  15.786  1.254   1.000 9.240  0 264  ALA   A O   1 ? 
ATOM   514  C CB  . ALA   A 1 67  ? 13.935  16.693  -1.630  1.000 9.972  0 264  ALA   A CB  1 ? 
ATOM   515  N N   . ALA   A 1 68  ? 14.635  17.110  1.464   1.000 9.408  0 265  ALA   A N   1 ? 
ATOM   516  C CA  . ALA   A 1 68  ? 14.179  18.062  2.497   1.000 9.541  0 265  ALA   A CA  1 ? 
ATOM   517  C C   . ALA   A 1 68  ? 14.173  19.442  1.841   1.000 9.918  0 265  ALA   A C   1 ? 
ATOM   518  O O   . ALA   A 1 68  ? 15.154  19.756  1.153   1.000 10.450 0 265  ALA   A O   1 ? 
ATOM   519  C CB  . ALA   A 1 68  ? 15.084  18.014  3.703   1.000 9.669  0 265  ALA   A CB  1 ? 
ATOM   520  N N   . ASP   A 1 69  ? 13.092  20.206  1.978   1.000 9.990  0 266  ASP   A N   1 ? 
ATOM   521  C CA  . ASP   A 1 69  ? 12.977  21.524  1.302   1.000 10.597 0 266  ASP   A CA  1 ? 
ATOM   522  C C   . ASP   A 1 69  ? 12.035  22.428  2.100   1.000 10.543 0 266  ASP   A C   1 ? 
ATOM   523  O O   . ASP   A 1 69  ? 11.415  21.950  3.074   1.000 9.952  0 266  ASP   A O   1 ? 
ATOM   524  C CB  . ASP   A 1 69  ? 12.522  21.344  -0.149  1.000 11.090 0 266  ASP   A CB  1 ? 
ATOM   525  C CG  . ASP   A 1 69  ? 13.012  22.405  -1.122  1.000 11.862 0 266  ASP   A CG  1 ? 
ATOM   526  O OD1 . ASP   A 1 69  ? 13.572  23.421  -0.668  1.000 11.386 0 266  ASP   A OD1 1 ? 
ATOM   527  O OD2 . ASP   A 1 69  ? 12.819  22.199  -2.337  1.000 14.129 0 266  ASP   A OD2 1 ? 
ATOM   528  N N   . ASN   A 1 70  ? 11.980  23.701  1.703   1.000 11.250 0 267  ASN   A N   1 ? 
ATOM   529  C CA  . ASN   A 1 70  ? 11.051  24.735  2.226   1.000 12.052 0 267  ASN   A CA  1 ? 
ATOM   530  C C   . ASN   A 1 70  ? 10.083  25.116  1.102   1.000 11.812 0 267  ASN   A C   1 ? 
ATOM   531  O O   . ASN   A 1 70  ? 10.500  25.080  -0.073  1.000 11.974 0 267  ASN   A O   1 ? 
ATOM   532  C CB  . ASN   A 1 70  ? 11.791  25.992  2.692   1.000 13.059 0 267  ASN   A CB  1 ? 
ATOM   533  C CG  . ASN   A 1 70  ? 12.701  25.779  3.884   1.000 14.199 0 267  ASN   A CG  1 ? 
ATOM   534  O OD1 . ASN   A 1 70  ? 13.122  24.662  4.181   1.000 15.906 0 267  ASN   A OD1 1 ? 
ATOM   535  N ND2 . ASN   A 1 70  ? 13.013  26.859  4.577   1.000 15.054 0 267  ASN   A ND2 1 ? 
ATOM   536  N N   . LYS   A 1 71  ? 8.845   25.478  1.439   1.000 11.707 0 268  LYS   A N   1 ? 
ATOM   537  C CA  . LYS   A 1 71  ? 7.876   26.036  0.459   1.000 11.920 0 268  LYS   A CA  1 ? 
ATOM   538  C C   . LYS   A 1 71  ? 7.136   27.212  1.097   1.000 11.707 0 268  LYS   A C   1 ? 
ATOM   539  O O   . LYS   A 1 71  ? 6.479   27.019  2.132   1.000 11.549 0 268  LYS   A O   1 ? 
ATOM   540  C CB  . LYS   A 1 71  ? 6.890   24.971  -0.025  1.000 12.548 0 268  LYS   A CB  1 ? 
ATOM   541  C CG  . LYS   A 1 71  ? 6.097   25.360  -1.266  1.000 13.250 0 268  LYS   A CG  1 ? 
ATOM   542  C CD  . LYS   A 1 71  ? 5.337   24.204  -1.877  1.000 13.976 0 268  LYS   A CD  1 ? 
ATOM   543  C CE  . LYS   A 1 71  ? 4.797   24.500  -3.261  1.000 14.517 0 268  LYS   A CE  1 ? 
ATOM   544  N NZ  . LYS   A 1 71  ? 4.274   23.275  -3.913  1.000 14.899 0 268  LYS   A NZ  1 ? 
ATOM   545  N N   . ASP   A 1 72  ? 7.261   28.389  0.485   1.000 11.555 0 269  ASP   A N   1 ? 
ATOM   546  C CA  . ASP   A 1 72  ? 6.588   29.640  0.915   1.000 11.562 0 269  ASP   A CA  1 ? 
ATOM   547  C C   . ASP   A 1 72  ? 5.311   29.809  0.084   1.000 10.971 0 269  ASP   A C   1 ? 
ATOM   548  O O   . ASP   A 1 72  ? 5.427   30.022  -1.135  1.000 10.902 0 269  ASP   A O   1 ? 
ATOM   549  C CB  . ASP   A 1 72  ? 7.544   30.823  0.760   1.000 11.997 0 269  ASP   A CB  1 ? 
ATOM   550  C CG  . ASP   A 1 72  ? 7.024   32.139  1.311   1.000 12.680 0 269  ASP   A CG  1 ? 
ATOM   551  O OD1 . ASP   A 1 72  ? 5.824   32.211  1.650   1.000 12.589 0 269  ASP   A OD1 1 ? 
ATOM   552  O OD2 . ASP   A 1 72  ? 7.834   33.086  1.397   1.000 14.181 0 269  ASP   A OD2 1 ? 
ATOM   553  N N   . ASN   A 1 73  ? 4.134   29.715  0.705   1.000 10.490 0 270  ASN   A N   1 ? 
ATOM   554  C CA  . ASN   A 1 73  ? 2.845   29.840  -0.025  1.000 10.577 0 270  ASN   A CA  1 ? 
ATOM   555  C C   . ASN   A 1 73  ? 2.457   31.318  -0.165  1.000 10.746 0 270  ASN   A C   1 ? 
ATOM   556  O O   . ASN   A 1 73  ? 1.436   31.577  -0.812  1.000 11.004 0 270  ASN   A O   1 ? 
ATOM   557  C CB  . ASN   A 1 73  ? 1.730   29.013  0.621   1.000 10.381 0 270  ASN   A CB  1 ? 
ATOM   558  C CG  . ASN   A 1 73  ? 1.315   29.484  1.998   1.000 10.191 0 270  ASN   A CG  1 ? 
ATOM   559  O OD1 . ASN   A 1 73  ? 1.725   30.549  2.460   1.000 9.958  0 270  ASN   A OD1 1 ? 
ATOM   560  N ND2 . ASN   A 1 73  ? 0.479   28.699  2.654   1.000 10.457 0 270  ASN   A ND2 1 ? 
ATOM   561  N N   . GLY   A 1 74  ? 3.235   32.242  0.411   1.000 10.956 0 271  GLY   A N   1 ? 
ATOM   562  C CA  . GLY   A 1 74  ? 2.965   33.693  0.377   1.000 11.267 0 271  GLY   A CA  1 ? 
ATOM   563  C C   . GLY   A 1 74  ? 2.517   34.231  1.724   1.000 11.519 0 271  GLY   A C   1 ? 
ATOM   564  O O   . GLY   A 1 74  ? 2.544   35.462  1.896   1.000 12.402 0 271  GLY   A O   1 ? 
ATOM   565  N N   . THR   A 1 75  ? 2.107   33.356  2.648   1.000 11.471 0 272  THR   A N   1 ? 
ATOM   566  C CA  . THR   A 1 75  ? 1.690   33.733  4.026   1.000 11.541 0 272  THR   A CA  1 ? 
ATOM   567  C C   . THR   A 1 75  ? 2.615   33.073  5.052   1.000 11.513 0 272  THR   A C   1 ? 
ATOM   568  O O   . THR   A 1 75  ? 3.063   33.781  5.978   1.000 11.813 0 272  THR   A O   1 ? 
ATOM   569  C CB  . THR   A 1 75  ? 0.222   33.376  4.286   1.000 11.490 0 272  THR   A CB  1 ? 
ATOM   570  O OG1 . THR   A 1 75  ? -0.560  34.015  3.275   1.000 12.007 0 272  THR   A OG1 1 ? 
ATOM   571  C CG2 . THR   A 1 75  ? -0.250  33.815  5.655   1.000 11.607 0 272  THR   A CG2 1 ? 
ATOM   572  N N   . TRP   A 1 76  ? 2.872   31.772  4.918   1.000 11.324 0 273  TRP   A N   1 ? 
ATOM   573  C CA  . TRP   A 1 76  ? 3.740   31.024  5.862   1.000 11.365 0 273  TRP   A CA  1 ? 
ATOM   574  C C   . TRP   A 1 76  ? 4.638   30.055  5.095   1.000 11.568 0 273  TRP   A C   1 ? 
ATOM   575  O O   . TRP   A 1 76  ? 4.328   29.728  3.928   1.000 11.395 0 273  TRP   A O   1 ? 
ATOM   576  C CB  . TRP   A 1 76  ? 2.906   30.325  6.946   1.000 11.316 0 273  TRP   A CB  1 ? 
ATOM   577  C CG  . TRP   A 1 76  ? 2.077   29.163  6.489   1.000 11.264 0 273  TRP   A CG  1 ? 
ATOM   578  C CD1 . TRP   A 1 76  ? 2.469   27.858  6.413   1.000 11.399 0 273  TRP   A CD1 1 ? 
ATOM   579  C CD2 . TRP   A 1 76  ? 0.687   29.182  6.111   1.000 11.297 0 273  TRP   A CD2 1 ? 
ATOM   580  N NE1 . TRP   A 1 76  ? 1.432   27.073  5.988   1.000 11.417 0 273  TRP   A NE1 1 ? 
ATOM   581  C CE2 . TRP   A 1 76  ? 0.323   27.853  5.802   1.000 11.392 0 273  TRP   A CE2 1 ? 
ATOM   582  C CE3 . TRP   A 1 76  ? -0.281  30.187  5.998   1.000 11.572 0 273  TRP   A CE3 1 ? 
ATOM   583  C CZ2 . TRP   A 1 76  ? -0.959  27.510  5.378   1.000 11.484 0 273  TRP   A CZ2 1 ? 
ATOM   584  C CZ3 . TRP   A 1 76  ? -1.549  29.847  5.579   1.000 11.571 0 273  TRP   A CZ3 1 ? 
ATOM   585  C CH2 . TRP   A 1 76  ? -1.881  28.526  5.277   1.000 11.504 0 273  TRP   A CH2 1 ? 
ATOM   586  N N   . THR   A 1 77  ? 5.729   29.640  5.737   1.000 11.891 0 274  THR   A N   1 ? 
ATOM   587  C CA  . THR   A 1 77  ? 6.700   28.665  5.187   1.000 12.328 0 274  THR   A CA  1 ? 
ATOM   588  C C   . THR   A 1 77  ? 6.349   27.273  5.713   1.000 11.841 0 274  THR   A C   1 ? 
ATOM   589  O O   . THR   A 1 77  ? 6.103   27.131  6.928   1.000 12.182 0 274  THR   A O   1 ? 
ATOM   590  C CB  . THR   A 1 77  ? 8.141   29.074  5.506   1.000 13.267 0 274  THR   A CB  1 ? 
ATOM   591  O OG1 . THR   A 1 77  ? 8.373   30.303  4.818   1.000 14.538 0 274  THR   A OG1 1 ? 
ATOM   592  C CG2 . THR   A 1 77  ? 9.163   28.044  5.076   1.000 13.652 0 274  THR   A CG2 1 ? 
ATOM   593  N N   . GLN   A 1 78  ? 6.288   26.309  4.797   1.000 11.252 0 275  GLN   A N   1 ? 
ATOM   594  C CA  A GLN   A 1 78  ? 6.115   24.868  5.104   0.500 11.003 0 275  GLN   A CA  1 ? 
ATOM   595  C CA  B GLN   A 1 78  ? 6.114   24.865  5.098   0.500 10.955 0 275  GLN   A CA  1 ? 
ATOM   596  C C   . GLN   A 1 78  ? 7.482   24.187  5.012   1.000 10.465 0 275  GLN   A C   1 ? 
ATOM   597  O O   . GLN   A 1 78  ? 8.256   24.550  4.115   1.000 10.238 0 275  GLN   A O   1 ? 
ATOM   598  C CB  A GLN   A 1 78  ? 5.124   24.238  4.126   0.500 11.266 0 275  GLN   A CB  1 ? 
ATOM   599  C CB  B GLN   A 1 78  ? 5.160   24.210  4.100   0.500 11.151 0 275  GLN   A CB  1 ? 
ATOM   600  C CG  A GLN   A 1 78  ? 3.764   24.917  4.124   0.500 11.594 0 275  GLN   A CG  1 ? 
ATOM   601  C CG  B GLN   A 1 78  ? 3.717   24.671  4.226   0.500 11.407 0 275  GLN   A CG  1 ? 
ATOM   602  C CD  A GLN   A 1 78  ? 2.889   24.423  3.000   0.500 11.826 0 275  GLN   A CD  1 ? 
ATOM   603  C CD  B GLN   A 1 78  ? 2.890   24.157  3.075   0.500 11.558 0 275  GLN   A CD  1 ? 
ATOM   604  O OE1 A GLN   A 1 78  ? 3.016   23.290  2.538   0.500 11.899 0 275  GLN   A OE1 1 ? 
ATOM   605  O OE1 B GLN   A 1 78  ? 3.399   23.922  1.980   0.500 11.423 0 275  GLN   A OE1 1 ? 
ATOM   606  N NE2 A GLN   A 1 78  ? 1.985   25.280  2.556   0.500 11.986 0 275  GLN   A NE2 1 ? 
ATOM   607  N NE2 B GLN   A 1 78  ? 1.602   23.979  3.315   0.500 11.669 0 275  GLN   A NE2 1 ? 
ATOM   608  N N   . LEU   A 1 79  ? 7.747   23.245  5.909   1.000 9.678  0 276  LEU   A N   1 ? 
ATOM   609  C CA  . LEU   A 1 79  ? 8.984   22.428  5.878   1.000 9.408  0 276  LEU   A CA  1 ? 
ATOM   610  C C   . LEU   A 1 79  ? 8.604   21.034  5.376   1.000 9.044  0 276  LEU   A C   1 ? 
ATOM   611  O O   . LEU   A 1 79  ? 7.725   20.402  5.978   1.000 9.201  0 276  LEU   A O   1 ? 
ATOM   612  C CB  . LEU   A 1 79  ? 9.609   22.399  7.273   1.000 9.496  0 276  LEU   A CB  1 ? 
ATOM   613  C CG  . LEU   A 1 79  ? 9.928   23.766  7.876   1.000 9.671  0 276  LEU   A CG  1 ? 
ATOM   614  C CD1 . LEU   A 1 79  ? 10.375  23.622  9.320   1.000 9.641  0 276  LEU   A CD1 1 ? 
ATOM   615  C CD2 . LEU   A 1 79  ? 10.990  24.501  7.073   1.000 9.947  0 276  LEU   A CD2 1 ? 
ATOM   616  N N   . TRP   A 1 80  ? 9.224   20.602  4.280   1.000 8.682  0 277  TRP   A N   1 ? 
ATOM   617  C CA  . TRP   A 1 80  ? 8.835   19.392  3.514   1.000 8.598  0 277  TRP   A CA  1 ? 
ATOM   618  C C   . TRP   A 1 80  ? 9.881   18.290  3.671   1.000 8.422  0 277  TRP   A C   1 ? 
ATOM   619  O O   . TRP   A 1 80  ? 11.086  18.595  3.577   1.000 7.904  0 277  TRP   A O   1 ? 
ATOM   620  C CB  . TRP   A 1 80  ? 8.676   19.740  2.033   1.000 8.800  0 277  TRP   A CB  1 ? 
ATOM   621  C CG  . TRP   A 1 80  ? 7.393   20.420  1.673   1.000 8.998  0 277  TRP   A CG  1 ? 
ATOM   622  C CD1 . TRP   A 1 80  ? 6.702   21.349  2.394   1.000 9.291  0 277  TRP   A CD1 1 ? 
ATOM   623  C CD2 . TRP   A 1 80  ? 6.661   20.233  0.452   1.000 9.120  0 277  TRP   A CD2 1 ? 
ATOM   624  N NE1 . TRP   A 1 80  ? 5.579   21.737  1.712   1.000 9.276  0 277  TRP   A NE1 1 ? 
ATOM   625  C CE2 . TRP   A 1 80  ? 5.529   21.071  0.517   1.000 9.152  0 277  TRP   A CE2 1 ? 
ATOM   626  C CE3 . TRP   A 1 80  ? 6.858   19.441  -0.683  1.000 9.118  0 277  TRP   A CE3 1 ? 
ATOM   627  C CZ2 . TRP   A 1 80  ? 4.593   21.130  -0.514  1.000 9.187  0 277  TRP   A CZ2 1 ? 
ATOM   628  C CZ3 . TRP   A 1 80  ? 5.925   19.490  -1.693  1.000 9.419  0 277  TRP   A CZ3 1 ? 
ATOM   629  C CH2 . TRP   A 1 80  ? 4.811   20.327  -1.609  1.000 9.254  0 277  TRP   A CH2 1 ? 
ATOM   630  N N   . LEU   A 1 81  ? 9.422   17.050  3.845   1.000 8.638  0 278  LEU   A N   1 ? 
ATOM   631  C CA  . LEU   A 1 81  ? 10.225  15.821  3.625   1.000 8.924  0 278  LEU   A CA  1 ? 
ATOM   632  C C   . LEU   A 1 81  ? 9.522   15.005  2.545   1.000 8.628  0 278  LEU   A C   1 ? 
ATOM   633  O O   . LEU   A 1 81  ? 8.345   14.654  2.745   1.000 8.730  0 278  LEU   A O   1 ? 
ATOM   634  C CB  . LEU   A 1 81  ? 10.338  15.003  4.914   1.000 9.591  0 278  LEU   A CB  1 ? 
ATOM   635  C CG  . LEU   A 1 81  ? 11.181  15.601  6.036   1.000 10.368 0 278  LEU   A CG  1 ? 
ATOM   636  C CD1 . LEU   A 1 81  ? 11.198  14.661  7.227   1.000 10.599 0 278  LEU   A CD1 1 ? 
ATOM   637  C CD2 . LEU   A 1 81  ? 12.598  15.903  5.581   1.000 10.769 0 278  LEU   A CD2 1 ? 
ATOM   638  N N   . VAL   A 1 82  ? 10.220  14.725  1.449   1.000 8.326  0 279  VAL   A N   1 ? 
ATOM   639  C CA  . VAL   A 1 82  ? 9.646   14.040  0.261   1.000 8.165  0 279  VAL   A CA  1 ? 
ATOM   640  C C   . VAL   A 1 82  ? 10.266  12.645  0.165   1.000 8.031  0 279  VAL   A C   1 ? 
ATOM   641  O O   . VAL   A 1 82  ? 11.496  12.521  0.331   1.000 7.794  0 279  VAL   A O   1 ? 
ATOM   642  C CB  . VAL   A 1 82  ? 9.880   14.854  -1.023  1.000 8.296  0 279  VAL   A CB  1 ? 
ATOM   643  C CG1 . VAL   A 1 82  ? 9.184   14.217  -2.214  1.000 8.396  0 279  VAL   A CG1 1 ? 
ATOM   644  C CG2 . VAL   A 1 82  ? 9.455   16.309  -0.862  1.000 8.489  0 279  VAL   A CG2 1 ? 
ATOM   645  N N   . SER   A 1 83  ? 9.433   11.638  -0.081  1.000 7.789  0 280  SER   A N   1 ? 
ATOM   646  C CA  . SER   A 1 83  ? 9.851   10.220  -0.199  1.000 7.908  0 280  SER   A CA  1 ? 
ATOM   647  C C   . SER   A 1 83  ? 9.169   9.554   -1.390  1.000 7.945  0 280  SER   A C   1 ? 
ATOM   648  O O   . SER   A 1 83  ? 8.197   10.116  -1.939  1.000 7.752  0 280  SER   A O   1 ? 
ATOM   649  C CB  . SER   A 1 83  ? 9.537   9.455   1.058   1.000 7.888  0 280  SER   A CB  1 ? 
ATOM   650  O OG  . SER   A 1 83  ? 8.137   9.241   1.178   1.000 7.912  0 280  SER   A OG  1 ? 
ATOM   651  N N   . ASP   A 1 84  ? 9.627   8.343   -1.697  1.000 8.124  0 281  ASP   A N   1 ? 
ATOM   652  C CA  . ASP   A 1 84  ? 8.912   7.385   -2.573  1.000 8.409  0 281  ASP   A CA  1 ? 
ATOM   653  C C   . ASP   A 1 84  ? 7.477   7.233   -2.060  1.000 8.326  0 281  ASP   A C   1 ? 
ATOM   654  O O   . ASP   A 1 84  ? 7.266   7.317   -0.828  1.000 8.109  0 281  ASP   A O   1 ? 
ATOM   655  C CB  . ASP   A 1 84  ? 9.586   6.012   -2.576  1.000 8.731  0 281  ASP   A CB  1 ? 
ATOM   656  C CG  . ASP   A 1 84  ? 11.026  6.017   -3.050  1.000 9.223  0 281  ASP   A CG  1 ? 
ATOM   657  O OD1 . ASP   A 1 84  ? 11.416  6.978   -3.748  1.000 10.076 0 281  ASP   A OD1 1 ? 
ATOM   658  O OD2 . ASP   A 1 84  ? 11.747  5.056   -2.714  1.000 10.050 0 281  ASP   A OD2 1 ? 
ATOM   659  N N   . TYR   A 1 85  ? 6.533   6.987   -2.968  1.000 8.454  0 282  TYR   A N   1 ? 
ATOM   660  C CA  . TYR   A 1 85  ? 5.118   6.697   -2.641  1.000 8.772  0 282  TYR   A CA  1 ? 
ATOM   661  C C   . TYR   A 1 85  ? 4.878   5.190   -2.737  1.000 8.926  0 282  TYR   A C   1 ? 
ATOM   662  O O   . TYR   A 1 85  ? 5.252   4.573   -3.746  1.000 9.166  0 282  TYR   A O   1 ? 
ATOM   663  C CB  . TYR   A 1 85  ? 4.167   7.456   -3.566  1.000 9.004  0 282  TYR   A CB  1 ? 
ATOM   664  C CG  . TYR   A 1 85  ? 2.717   7.164   -3.282  1.000 9.288  0 282  TYR   A CG  1 ? 
ATOM   665  C CD1 . TYR   A 1 85  ? 2.118   7.626   -2.123  1.000 9.552  0 282  TYR   A CD1 1 ? 
ATOM   666  C CD2 . TYR   A 1 85  ? 1.954   6.397   -4.148  1.000 9.584  0 282  TYR   A CD2 1 ? 
ATOM   667  C CE1 . TYR   A 1 85  ? 0.789   7.352   -1.842  1.000 9.755  0 282  TYR   A CE1 1 ? 
ATOM   668  C CE2 . TYR   A 1 85  ? 0.625   6.111   -3.879  1.000 9.844  0 282  TYR   A CE2 1 ? 
ATOM   669  C CZ  . TYR   A 1 85  ? 0.040   6.593   -2.722  1.000 10.025 0 282  TYR   A CZ  1 ? 
ATOM   670  O OH  . TYR   A 1 85  ? -1.269  6.322   -2.436  1.000 10.915 0 282  TYR   A OH  1 ? 
ATOM   671  N N   . HIS   A 1 86  ? 4.258   4.626   -1.700  1.000 8.910  0 283  HIS   A N   1 ? 
ATOM   672  C CA  . HIS   A 1 86  ? 3.857   3.197   -1.628  1.000 9.038  0 283  HIS   A CA  1 ? 
ATOM   673  C C   . HIS   A 1 86  ? 2.342   3.120   -1.433  1.000 9.291  0 283  HIS   A C   1 ? 
ATOM   674  O O   . HIS   A 1 86  ? 1.868   3.485   -0.353  1.000 9.171  0 283  HIS   A O   1 ? 
ATOM   675  C CB  . HIS   A 1 86  ? 4.650   2.491   -0.525  1.000 9.021  0 283  HIS   A CB  1 ? 
ATOM   676  C CG  . HIS   A 1 86  ? 6.119   2.522   -0.775  1.000 9.167  0 283  HIS   A CG  1 ? 
ATOM   677  N ND1 . HIS   A 1 86  ? 6.685   1.931   -1.884  1.000 9.348  0 283  HIS   A ND1 1 ? 
ATOM   678  C CD2 . HIS   A 1 86  ? 7.135   3.091   -0.089  1.000 9.243  0 283  HIS   A CD2 1 ? 
ATOM   679  C CE1 . HIS   A 1 86  ? 7.986   2.127   -1.867  1.000 9.377  0 283  HIS   A CE1 1 ? 
ATOM   680  N NE2 . HIS   A 1 86  ? 8.288   2.835   -0.776  1.000 9.498  0 283  HIS   A NE2 1 ? 
ATOM   681  N N   . GLU   A 1 87  ? 1.621   2.663   -2.457  1.000 9.718  0 284  GLU   A N   1 ? 
ATOM   682  C CA  . GLU   A 1 87  ? 0.136   2.697   -2.523  1.000 10.134 0 284  GLU   A CA  1 ? 
ATOM   683  C C   . GLU   A 1 87  ? -0.500  1.962   -1.333  1.000 10.337 0 284  GLU   A C   1 ? 
ATOM   684  O O   . GLU   A 1 87  ? -1.584  2.388   -0.906  1.000 10.737 0 284  GLU   A O   1 ? 
ATOM   685  C CB  . GLU   A 1 87  ? -0.343  2.086   -3.840  1.000 10.433 0 284  GLU   A CB  1 ? 
ATOM   686  N N   . HIS   A 1 88  ? 0.123   0.896   -0.821  1.000 10.433 0 285  HIS   A N   1 ? 
ATOM   687  C CA  . HIS   A 1 88  ? -0.449  0.064   0.276   1.000 10.453 0 285  HIS   A CA  1 ? 
ATOM   688  C C   . HIS   A 1 88  ? -0.444  0.826   1.606   1.000 9.981  0 285  HIS   A C   1 ? 
ATOM   689  O O   . HIS   A 1 88  ? -1.223  0.450   2.498   1.000 10.234 0 285  HIS   A O   1 ? 
ATOM   690  C CB  . HIS   A 1 88  ? 0.300   -1.264  0.441   1.000 11.179 0 285  HIS   A CB  1 ? 
ATOM   691  C CG  . HIS   A 1 88  ? -0.002  -2.279  -0.608  1.000 11.890 0 285  HIS   A CG  1 ? 
ATOM   692  N ND1 . HIS   A 1 88  ? -1.291  -2.573  -1.008  1.000 12.599 0 285  HIS   A ND1 1 ? 
ATOM   693  C CD2 . HIS   A 1 88  ? 0.810   -3.095  -1.311  1.000 12.521 0 285  HIS   A CD2 1 ? 
ATOM   694  C CE1 . HIS   A 1 88  ? -1.254  -3.508  -1.935  1.000 12.712 0 285  HIS   A CE1 1 ? 
ATOM   695  N NE2 . HIS   A 1 88  ? 0.023   -3.845  -2.135  1.000 13.114 0 285  HIS   A NE2 1 ? 
ATOM   696  N N   . GLY   A 1 89  ? 0.412   1.838   1.755   1.000 9.318  0 286  GLY   A N   1 ? 
ATOM   697  C CA  . GLY   A 1 89  ? 0.552   2.582   3.019   1.000 8.953  0 286  GLY   A CA  1 ? 
ATOM   698  C C   . GLY   A 1 89  ? 1.126   1.709   4.123   1.000 8.509  0 286  GLY   A C   1 ? 
ATOM   699  O O   . GLY   A 1 89  ? 1.987   0.848   3.834   1.000 8.398  0 286  GLY   A O   1 ? 
ATOM   700  N N   . SER   A 1 90  ? 0.675   1.924   5.357   1.000 8.071  0 287  SER   A N   1 ? 
ATOM   701  C CA  . SER   A 1 90  ? 1.306   1.334   6.562   1.000 7.925  0 287  SER   A CA  1 ? 
ATOM   702  C C   . SER   A 1 90  ? 1.005   -0.163  6.663   1.000 7.783  0 287  SER   A C   1 ? 
ATOM   703  O O   . SER   A 1 90  ? -0.070  -0.615  6.216   1.000 7.682  0 287  SER   A O   1 ? 
ATOM   704  C CB  . SER   A 1 90  ? 0.883   2.042   7.811   1.000 7.938  0 287  SER   A CB  1 ? 
ATOM   705  O OG  . SER   A 1 90  ? -0.456  1.715   8.146   1.000 8.084  0 287  SER   A OG  1 ? 
ATOM   706  N N   . LEU   A 1 91  ? 1.929   -0.900  7.271   1.000 7.651  0 288  LEU   A N   1 ? 
ATOM   707  C CA  . LEU   A 1 91  ? 1.749   -2.331  7.609   1.000 7.682  0 288  LEU   A CA  1 ? 
ATOM   708  C C   . LEU   A 1 91  ? 0.501   -2.480  8.488   1.000 7.888  0 288  LEU   A C   1 ? 
ATOM   709  O O   . LEU   A 1 91  ? -0.257  -3.437  8.285   1.000 7.884  0 288  LEU   A O   1 ? 
ATOM   710  C CB  . LEU   A 1 91  ? 3.011   -2.831  8.313   1.000 7.594  0 288  LEU   A CB  1 ? 
ATOM   711  C CG  . LEU   A 1 91  ? 2.981   -4.296  8.740   1.000 7.545  0 288  LEU   A CG  1 ? 
ATOM   712  C CD1 . LEU   A 1 91  ? 2.823   -5.219  7.540   1.000 7.509  0 288  LEU   A CD1 1 ? 
ATOM   713  C CD2 . LEU   A 1 91  ? 4.235   -4.644  9.526   1.000 7.653  0 288  LEU   A CD2 1 ? 
ATOM   714  N N   . PHE   A 1 92  ? 0.262   -1.539  9.402   1.000 8.024  0 289  PHE   A N   1 ? 
ATOM   715  C CA  . PHE   A 1 92  ? -0.962  -1.521  10.244  1.000 8.315  0 289  PHE   A CA  1 ? 
ATOM   716  C C   . PHE   A 1 92  ? -2.204  -1.576  9.344   1.000 8.540  0 289  PHE   A C   1 ? 
ATOM   717  O O   . PHE   A 1 92  ? -3.056  -2.466  9.522   1.000 8.562  0 289  PHE   A O   1 ? 
ATOM   718  C CB  . PHE   A 1 92  ? -0.969  -0.295  11.156  1.000 8.323  0 289  PHE   A CB  1 ? 
ATOM   719  C CG  . PHE   A 1 92  ? -2.235  -0.133  11.958  1.000 8.333  0 289  PHE   A CG  1 ? 
ATOM   720  C CD1 . PHE   A 1 92  ? -2.414  -0.821  13.148  1.000 8.400  0 289  PHE   A CD1 1 ? 
ATOM   721  C CD2 . PHE   A 1 92  ? -3.253  0.697   11.515  1.000 8.578  0 289  PHE   A CD2 1 ? 
ATOM   722  C CE1 . PHE   A 1 92  ? -3.583  -0.680  13.880  1.000 8.585  0 289  PHE   A CE1 1 ? 
ATOM   723  C CE2 . PHE   A 1 92  ? -4.418  0.843   12.253  1.000 8.668  0 289  PHE   A CE2 1 ? 
ATOM   724  C CZ  . PHE   A 1 92  ? -4.583  0.152   13.432  1.000 8.656  0 289  PHE   A CZ  1 ? 
ATOM   725  N N   . ASP   A 1 93  ? -2.326  -0.645  8.397   1.000 8.825  0 290  ASP   A N   1 ? 
ATOM   726  C CA  . ASP   A 1 93  ? -3.508  -0.582  7.495   1.000 9.105  0 290  ASP   A CA  1 ? 
ATOM   727  C C   . ASP   A 1 93  ? -3.574  -1.864  6.654   1.000 9.029  0 290  ASP   A C   1 ? 
ATOM   728  O O   . ASP   A 1 93  ? -4.675  -2.423  6.509   1.000 8.979  0 290  ASP   A O   1 ? 
ATOM   729  C CB  . ASP   A 1 93  ? -3.484  0.678   6.629   1.000 9.637  0 290  ASP   A CB  1 ? 
ATOM   730  C CG  . ASP   A 1 93  ? -3.867  1.950   7.369   1.000 10.120 0 290  ASP   A CG  1 ? 
ATOM   731  O OD1 . ASP   A 1 93  ? -4.275  1.864   8.543   1.000 10.471 0 290  ASP   A OD1 1 ? 
ATOM   732  O OD2 . ASP   A 1 93  ? -3.774  3.031   6.751   1.000 11.185 0 290  ASP   A OD2 1 ? 
ATOM   733  N N   . TYR   A 1 94  ? -2.442  -2.324  6.123   1.000 9.029  0 291  TYR   A N   1 ? 
ATOM   734  C CA  . TYR   A 1 94  ? -2.347  -3.538  5.271   1.000 9.338  0 291  TYR   A CA  1 ? 
ATOM   735  C C   . TYR   A 1 94  ? -2.866  -4.762  6.038   1.000 9.293  0 291  TYR   A C   1 ? 
ATOM   736  O O   . TYR   A 1 94  ? -3.689  -5.520  5.487   1.000 9.116  0 291  TYR   A O   1 ? 
ATOM   737  C CB  . TYR   A 1 94  ? -0.899  -3.717  4.812   1.000 9.706  0 291  TYR   A CB  1 ? 
ATOM   738  C CG  . TYR   A 1 94  ? -0.655  -4.829  3.826   1.000 10.207 0 291  TYR   A CG  1 ? 
ATOM   739  C CD1 . TYR   A 1 94  ? -0.705  -4.598  2.460   1.000 10.495 0 291  TYR   A CD1 1 ? 
ATOM   740  C CD2 . TYR   A 1 94  ? -0.328  -6.107  4.254   1.000 10.685 0 291  TYR   A CD2 1 ? 
ATOM   741  C CE1 . TYR   A 1 94  ? -0.456  -5.610  1.545   1.000 11.040 0 291  TYR   A CE1 1 ? 
ATOM   742  C CE2 . TYR   A 1 94  ? -0.081  -7.130  3.353   1.000 11.193 0 291  TYR   A CE2 1 ? 
ATOM   743  C CZ  . TYR   A 1 94  ? -0.142  -6.881  1.993   1.000 11.335 0 291  TYR   A CZ  1 ? 
ATOM   744  O OH  . TYR   A 1 94  ? 0.105   -7.889  1.106   1.000 12.922 0 291  TYR   A OH  1 ? 
ATOM   745  N N   . LEU   A 1 95  ? -2.404  -4.958  7.276   1.000 9.075  0 292  LEU   A N   1 ? 
ATOM   746  C CA  . LEU   A 1 95  ? -2.776  -6.136  8.109   1.000 9.159  0 292  LEU   A CA  1 ? 
ATOM   747  C C   . LEU   A 1 95  ? -4.247  -6.050  8.536   1.000 9.497  0 292  LEU   A C   1 ? 
ATOM   748  O O   . LEU   A 1 95  ? -4.838  -7.103  8.809   1.000 9.358  0 292  LEU   A O   1 ? 
ATOM   749  C CB  . LEU   A 1 95  ? -1.855  -6.222  9.329   1.000 9.025  0 292  LEU   A CB  1 ? 
ATOM   750  C CG  . LEU   A 1 95  ? -0.400  -6.585  9.037   1.000 8.952  0 292  LEU   A CG  1 ? 
ATOM   751  C CD1 . LEU   A 1 95  ? 0.417   -6.577  10.317  1.000 8.934  0 292  LEU   A CD1 1 ? 
ATOM   752  C CD2 . LEU   A 1 95  ? -0.281  -7.932  8.339   1.000 9.023  0 292  LEU   A CD2 1 ? 
ATOM   753  N N   . ASN   A 1 96  ? -4.823  -4.852  8.615   1.000 9.733  0 293  ASN   A N   1 ? 
ATOM   754  C CA  . ASN   A 1 96  ? -6.270  -4.681  8.910   1.000 10.171 0 293  ASN   A CA  1 ? 
ATOM   755  C C   . ASN   A 1 96  ? -7.090  -5.126  7.693   1.000 10.850 0 293  ASN   A C   1 ? 
ATOM   756  O O   . ASN   A 1 96  ? -8.146  -5.761  7.885   1.000 11.449 0 293  ASN   A O   1 ? 
ATOM   757  C CB  . ASN   A 1 96  ? -6.595  -3.249  9.339   1.000 10.044 0 293  ASN   A CB  1 ? 
ATOM   758  C CG  . ASN   A 1 96  ? -6.380  -3.043  10.822  1.000 10.145 0 293  ASN   A CG  1 ? 
ATOM   759  O OD1 . ASN   A 1 96  ? -5.289  -2.678  11.259  1.000 10.530 0 293  ASN   A OD1 1 ? 
ATOM   760  N ND2 . ASN   A 1 96  ? -7.401  -3.329  11.607  1.000 9.906  0 293  ASN   A ND2 1 ? 
ATOM   761  N N   . ARG   A 1 97  ? -6.619  -4.827  6.483   1.000 11.351 0 294  ARG   A N   1 ? 
ATOM   762  C CA  . ARG   A 1 97  ? -7.397  -5.052  5.237   1.000 12.230 0 294  ARG   A CA  1 ? 
ATOM   763  C C   . ARG   A 1 97  ? -7.249  -6.495  4.745   1.000 12.179 0 294  ARG   A C   1 ? 
ATOM   764  O O   . ARG   A 1 97  ? -8.245  -7.042  4.217   1.000 12.653 0 294  ARG   A O   1 ? 
ATOM   765  C CB  . ARG   A 1 97  ? -6.948  -4.090  4.136   1.000 13.095 0 294  ARG   A CB  1 ? 
ATOM   766  C CG  . ARG   A 1 97  ? -7.676  -4.309  2.819   1.000 14.187 0 294  ARG   A CG  1 ? 
ATOM   767  C CD  . ARG   A 1 97  ? -7.540  -3.153  1.854   1.000 15.183 0 294  ARG   A CD  1 ? 
ATOM   768  N NE  . ARG   A 1 97  ? -8.173  -3.473  0.580   1.000 16.176 0 294  ARG   A NE  1 ? 
ATOM   769  C CZ  . ARG   A 1 97  ? -8.177  -2.686  -0.491  1.000 16.881 0 294  ARG   A CZ  1 ? 
ATOM   770  N NH1 . ARG   A 1 97  ? -7.580  -1.505  -0.458  1.000 17.264 0 294  ARG   A NH1 1 ? 
ATOM   771  N NH2 . ARG   A 1 97  ? -8.776  -3.086  -1.598  1.000 17.402 0 294  ARG   A NH2 1 ? 
ATOM   772  N N   . TYR   A 1 98  ? -6.054  -7.076  4.865   1.000 11.793 0 295  TYR   A N   1 ? 
ATOM   773  C CA  . TYR   A 1 98  ? -5.677  -8.339  4.181   1.000 11.789 0 295  TYR   A CA  1 ? 
ATOM   774  C C   . TYR   A 1 98  ? -5.281  -9.415  5.197   1.000 11.882 0 295  TYR   A C   1 ? 
ATOM   775  O O   . TYR   A 1 98  ? -4.882  -9.095  6.332   1.000 11.825 0 295  TYR   A O   1 ? 
ATOM   776  C CB  . TYR   A 1 98  ? -4.514  -8.103  3.215   1.000 11.850 0 295  TYR   A CB  1 ? 
ATOM   777  C CG  . TYR   A 1 98  ? -4.738  -7.023  2.186   1.000 12.014 0 295  TYR   A CG  1 ? 
ATOM   778  C CD1 . TYR   A 1 98  ? -5.680  -7.168  1.177   1.000 12.254 0 295  TYR   A CD1 1 ? 
ATOM   779  C CD2 . TYR   A 1 98  ? -3.988  -5.857  2.203   1.000 12.097 0 295  TYR   A CD2 1 ? 
ATOM   780  C CE1 . TYR   A 1 98  ? -5.880  -6.180  0.225   1.000 12.562 0 295  TYR   A CE1 1 ? 
ATOM   781  C CE2 . TYR   A 1 98  ? -4.176  -4.860  1.260   1.000 12.294 0 295  TYR   A CE2 1 ? 
ATOM   782  C CZ  . TYR   A 1 98  ? -5.123  -5.022  0.266   1.000 12.548 0 295  TYR   A CZ  1 ? 
ATOM   783  O OH  . TYR   A 1 98  ? -5.306  -4.036  -0.663  1.000 13.072 0 295  TYR   A OH  1 ? 
ATOM   784  N N   . THR   A 1 99  ? -5.404  -10.675 4.780   1.000 11.986 0 296  THR   A N   1 ? 
ATOM   785  C CA  . THR   A 1 99  ? -4.651  -11.822 5.343   1.000 12.349 0 296  THR   A CA  1 ? 
ATOM   786  C C   . THR   A 1 99  ? -3.452  -12.079 4.431   1.000 12.398 0 296  THR   A C   1 ? 
ATOM   787  O O   . THR   A 1 99  ? -3.446  -11.558 3.293   1.000 12.781 0 296  THR   A O   1 ? 
ATOM   788  C CB  . THR   A 1 99  ? -5.530  -13.069 5.497   1.000 12.557 0 296  THR   A CB  1 ? 
ATOM   789  O OG1 . THR   A 1 99  ? -6.081  -13.391 4.219   1.000 12.814 0 296  THR   A OG1 1 ? 
ATOM   790  C CG2 . THR   A 1 99  ? -6.632  -12.878 6.515   1.000 12.784 0 296  THR   A CG2 1 ? 
ATOM   791  N N   . VAL   A 1 100 ? -2.467  -12.832 4.916   1.000 12.261 0 297  VAL   A N   1 ? 
ATOM   792  C CA  . VAL   A 1 100 ? -1.223  -13.147 4.160   1.000 12.407 0 297  VAL   A CA  1 ? 
ATOM   793  C C   . VAL   A 1 100 ? -1.041  -14.666 4.111   1.000 12.423 0 297  VAL   A C   1 ? 
ATOM   794  O O   . VAL   A 1 100 ? -1.570  -15.373 4.988   1.000 12.382 0 297  VAL   A O   1 ? 
ATOM   795  C CB  . VAL   A 1 100 ? 0.003   -12.433 4.765   1.000 12.357 0 297  VAL   A CB  1 ? 
ATOM   796  C CG1 . VAL   A 1 100 ? -0.168  -10.921 4.738   1.000 12.546 0 297  VAL   A CG1 1 ? 
ATOM   797  C CG2 . VAL   A 1 100 ? 0.320   -12.908 6.175   1.000 12.284 0 297  VAL   A CG2 1 ? 
ATOM   798  N N   . THR   A 1 101 ? -0.331  -15.140 3.091   1.000 12.805 0 298  THR   A N   1 ? 
ATOM   799  C CA  . THR   A 1 101 ? 0.131   -16.544 2.974   1.000 13.129 0 298  THR   A CA  1 ? 
ATOM   800  C C   . THR   A 1 101 ? 1.343   -16.724 3.892   1.000 13.245 0 298  THR   A C   1 ? 
ATOM   801  O O   . THR   A 1 101 ? 1.851   -15.713 4.411   1.000 12.657 0 298  THR   A O   1 ? 
ATOM   802  C CB  . THR   A 1 101 ? 0.483   -16.885 1.523   1.000 13.534 0 298  THR   A CB  1 ? 
ATOM   803  O OG1 . THR   A 1 101 ? 1.565   -16.027 1.159   1.000 13.913 0 298  THR   A OG1 1 ? 
ATOM   804  C CG2 . THR   A 1 101 ? -0.677  -16.709 0.566   1.000 13.805 0 298  THR   A CG2 1 ? 
ATOM   805  N N   . VAL   A 1 102 ? 1.803   -17.960 4.075   1.000 13.446 0 299  VAL   A N   1 ? 
ATOM   806  C CA  . VAL   A 1 102 ? 3.059   -18.250 4.824   1.000 13.431 0 299  VAL   A CA  1 ? 
ATOM   807  C C   . VAL   A 1 102 ? 4.205   -17.485 4.148   1.000 13.444 0 299  VAL   A C   1 ? 
ATOM   808  O O   . VAL   A 1 102 ? 4.957   -16.797 4.862   1.000 13.246 0 299  VAL   A O   1 ? 
ATOM   809  C CB  . VAL   A 1 102 ? 3.340   -19.762 4.908   1.000 13.586 0 299  VAL   A CB  1 ? 
ATOM   810  C CG1 . VAL   A 1 102 ? 4.761   -20.048 5.366   1.000 13.781 0 299  VAL   A CG1 1 ? 
ATOM   811  C CG2 . VAL   A 1 102 ? 2.332   -20.463 5.806   1.000 13.771 0 299  VAL   A CG2 1 ? 
ATOM   812  N N   . GLU   A 1 103 ? 4.328   -17.582 2.822   1.000 13.633 0 300  GLU   A N   1 ? 
ATOM   813  C CA  A GLU   A 1 103 ? 5.376   -16.872 2.036   0.500 13.642 0 300  GLU   A CA  1 ? 
ATOM   814  C CA  B GLU   A 1 103 ? 5.403   -16.877 2.076   0.500 13.556 0 300  GLU   A CA  1 ? 
ATOM   815  C C   . GLU   A 1 103 ? 5.229   -15.363 2.261   1.000 13.189 0 300  GLU   A C   1 ? 
ATOM   816  O O   . GLU   A 1 103 ? 6.257   -14.690 2.437   1.000 12.979 0 300  GLU   A O   1 ? 
ATOM   817  C CB  A GLU   A 1 103 ? 5.270   -17.213 0.547   0.500 14.201 0 300  GLU   A CB  1 ? 
ATOM   818  C CB  B GLU   A 1 103 ? 5.428   -17.305 0.607   0.500 13.983 0 300  GLU   A CB  1 ? 
ATOM   819  C CG  A GLU   A 1 103 ? 6.312   -16.519 -0.318  0.500 14.712 0 300  GLU   A CG  1 ? 
ATOM   820  C CG  B GLU   A 1 103 ? 6.035   -18.684 0.410   0.500 14.394 0 300  GLU   A CG  1 ? 
ATOM   821  C CD  A GLU   A 1 103 ? 6.128   -16.692 -1.817  0.500 15.122 0 300  GLU   A CD  1 ? 
ATOM   822  C CD  B GLU   A 1 103 ? 6.526   -18.987 -0.995  0.500 14.750 0 300  GLU   A CD  1 ? 
ATOM   823  O OE1 A GLU   A 1 103 ? 6.332   -15.706 -2.553  0.500 15.663 0 300  GLU   A OE1 1 ? 
ATOM   824  O OE1 B GLU   A 1 103 ? 7.747   -19.183 -1.160  0.500 15.081 0 300  GLU   A OE1 1 ? 
ATOM   825  O OE2 A GLU   A 1 103 ? 5.789   -17.813 -2.246  0.500 15.899 0 300  GLU   A OE2 1 ? 
ATOM   826  O OE2 B GLU   A 1 103 ? 5.684   -19.044 -1.916  0.500 15.420 0 300  GLU   A OE2 1 ? 
ATOM   827  N N   . GLY   A 1 104 ? 3.987   -14.867 2.245   1.000 12.440 0 301  GLY   A N   1 ? 
ATOM   828  C CA  . GLY   A 1 104 ? 3.675   -13.438 2.442   1.000 12.082 0 301  GLY   A CA  1 ? 
ATOM   829  C C   . GLY   A 1 104 ? 4.129   -12.955 3.807   1.000 11.697 0 301  GLY   A C   1 ? 
ATOM   830  O O   . GLY   A 1 104 ? 4.763   -11.883 3.888   1.000 11.527 0 301  GLY   A O   1 ? 
ATOM   831  N N   . MET   A 1 105 ? 3.816   -13.721 4.852   1.000 11.198 0 302  MET   A N   1 ? 
ATOM   832  C CA  . MET   A 1 105 ? 4.223   -13.425 6.250   1.000 11.030 0 302  MET   A CA  1 ? 
ATOM   833  C C   . MET   A 1 105 ? 5.749   -13.335 6.323   1.000 10.966 0 302  MET   A C   1 ? 
ATOM   834  O O   . MET   A 1 105 ? 6.265   -12.349 6.880   1.000 10.448 0 302  MET   A O   1 ? 
ATOM   835  C CB  . MET   A 1 105 ? 3.735   -14.515 7.208   1.000 11.065 0 302  MET   A CB  1 ? 
ATOM   836  C CG  . MET   A 1 105 ? 4.358   -14.433 8.589   1.000 11.125 0 302  MET   A CG  1 ? 
ATOM   837  S SD  . MET   A 1 105 ? 3.752   -15.718 9.697   1.000 11.530 0 302  MET   A SD  1 ? 
ATOM   838  C CE  . MET   A 1 105 ? 4.475   -17.174 8.943   1.000 11.408 0 302  MET   A CE  1 ? 
ATOM   839  N N   . ILE   A 1 106 ? 6.447   -14.336 5.788   1.000 11.160 0 303  ILE   A N   1 ? 
ATOM   840  C CA  . ILE   A 1 106 ? 7.933   -14.407 5.881   1.000 11.303 0 303  ILE   A CA  1 ? 
ATOM   841  C C   . ILE   A 1 106 ? 8.523   -13.194 5.148   1.000 11.263 0 303  ILE   A C   1 ? 
ATOM   842  O O   . ILE   A 1 106 ? 9.470   -12.600 5.686   1.000 11.249 0 303  ILE   A O   1 ? 
ATOM   843  C CB  . ILE   A 1 106 ? 8.475   -15.752 5.355   1.000 11.591 0 303  ILE   A CB  1 ? 
ATOM   844  C CG1 . ILE   A 1 106 ? 7.980   -16.926 6.204   1.000 11.799 0 303  ILE   A CG1 1 ? 
ATOM   845  C CG2 . ILE   A 1 106 ? 9.995   -15.714 5.283   1.000 11.725 0 303  ILE   A CG2 1 ? 
ATOM   846  C CD1 . ILE   A 1 106 ? 8.233   -18.287 5.598   1.000 12.102 0 303  ILE   A CD1 1 ? 
ATOM   847  N N   . LYS   A 1 107 ? 7.978   -12.823 3.985   1.000 11.288 0 304  LYS   A N   1 ? 
ATOM   848  C CA  A LYS   A 1 107 ? 8.487   -11.671 3.195   0.500 11.342 0 304  LYS   A CA  1 ? 
ATOM   849  C CA  B LYS   A 1 107 ? 8.465   -11.665 3.184   0.500 11.331 0 304  LYS   A CA  1 ? 
ATOM   850  C C   . LYS   A 1 107 ? 8.353   -10.382 4.017   1.000 11.027 0 304  LYS   A C   1 ? 
ATOM   851  O O   . LYS   A 1 107 ? 9.323   -9.607  4.030   1.000 11.043 0 304  LYS   A O   1 ? 
ATOM   852  C CB  A LYS   A 1 107 ? 7.760   -11.555 1.853   0.500 11.774 0 304  LYS   A CB  1 ? 
ATOM   853  C CB  B LYS   A 1 107 ? 7.685   -11.534 1.870   0.500 11.747 0 304  LYS   A CB  1 ? 
ATOM   854  C CG  A LYS   A 1 107 ? 8.386   -10.564 0.884   0.500 12.051 0 304  LYS   A CG  1 ? 
ATOM   855  C CG  B LYS   A 1 107 ? 8.118   -12.490 0.766   0.500 12.024 0 304  LYS   A CG  1 ? 
ATOM   856  C CD  A LYS   A 1 107 ? 8.008   -10.803 -0.559  0.500 12.476 0 304  LYS   A CD  1 ? 
ATOM   857  C CD  B LYS   A 1 107 ? 7.362   -12.316 -0.532  0.500 12.333 0 304  LYS   A CD  1 ? 
ATOM   858  C CE  A LYS   A 1 107 ? 6.514   -10.924 -0.765  0.500 12.761 0 304  LYS   A CE  1 ? 
ATOM   859  C CE  B LYS   A 1 107 ? 7.429   -10.903 -1.069  0.500 12.577 0 304  LYS   A CE  1 ? 
ATOM   860  N NZ  A LYS   A 1 107 ? 6.160   -11.007 -2.202  0.500 13.033 0 304  LYS   A NZ  1 ? 
ATOM   861  N NZ  B LYS   A 1 107 ? 6.922   -10.820 -2.458  0.500 12.802 0 304  LYS   A NZ  1 ? 
ATOM   862  N N   . LEU   A 1 108 ? 7.208   -10.171 4.674   1.000 10.388 0 305  LEU   A N   1 ? 
ATOM   863  C CA  . LEU   A 1 108 ? 6.973   -8.961  5.510   1.000 10.182 0 305  LEU   A CA  1 ? 
ATOM   864  C C   . LEU   A 1 108 ? 7.952   -8.953  6.690   1.000 9.864  0 305  LEU   A C   1 ? 
ATOM   865  O O   . LEU   A 1 108 ? 8.564   -7.902  6.948   1.000 9.704  0 305  LEU   A O   1 ? 
ATOM   866  C CB  . LEU   A 1 108 ? 5.526   -8.933  6.008   1.000 10.164 0 305  LEU   A CB  1 ? 
ATOM   867  C CG  . LEU   A 1 108 ? 4.445   -8.723  4.947   1.000 10.247 0 305  LEU   A CG  1 ? 
ATOM   868  C CD1 . LEU   A 1 108 ? 3.068   -8.977  5.537   1.000 10.410 0 305  LEU   A CD1 1 ? 
ATOM   869  C CD2 . LEU   A 1 108 ? 4.514   -7.325  4.347   1.000 10.226 0 305  LEU   A CD2 1 ? 
ATOM   870  N N   . ALA   A 1 109 ? 8.099   -10.084 7.385   1.000 9.570  0 306  ALA   A N   1 ? 
ATOM   871  C CA  . ALA   A 1 109 ? 8.948   -10.208 8.592   1.000 9.537  0 306  ALA   A CA  1 ? 
ATOM   872  C C   . ALA   A 1 109 ? 10.427  -10.079 8.207   1.000 9.496  0 306  ALA   A C   1 ? 
ATOM   873  O O   . ALA   A 1 109 ? 11.156  -9.325  8.877   1.000 9.264  0 306  ALA   A O   1 ? 
ATOM   874  C CB  . ALA   A 1 109 ? 8.668   -11.516 9.286   1.000 9.593  0 306  ALA   A CB  1 ? 
ATOM   875  N N   . LEU   A 1 110 ? 10.861  -10.794 7.166   1.000 9.603  0 307  LEU   A N   1 ? 
ATOM   876  C CA  . LEU   A 1 110 ? 12.280  -10.790 6.709   1.000 9.633  0 307  LEU   A CA  1 ? 
ATOM   877  C C   . LEU   A 1 110 ? 12.674  -9.384  6.238   1.000 9.532  0 307  LEU   A C   1 ? 
ATOM   878  O O   . LEU   A 1 110 ? 13.778  -8.923  6.585   1.000 9.366  0 307  LEU   A O   1 ? 
ATOM   879  C CB  . LEU   A 1 110 ? 12.459  -11.825 5.594   1.000 9.917  0 307  LEU   A CB  1 ? 
ATOM   880  C CG  . LEU   A 1 110 ? 13.835  -11.867 4.932   1.000 10.334 0 307  LEU   A CG  1 ? 
ATOM   881  C CD1 . LEU   A 1 110 ? 14.952  -11.988 5.960   1.000 10.497 0 307  LEU   A CD1 1 ? 
ATOM   882  C CD2 . LEU   A 1 110 ? 13.902  -13.012 3.931   1.000 10.651 0 307  LEU   A CD2 1 ? 
ATOM   883  N N   . SER   A 1 111 ? 11.815  -8.716  5.471   1.000 9.356  0 308  SER   A N   1 ? 
ATOM   884  C CA  . SER   A 1 111 ? 12.114  -7.366  4.928   1.000 9.356  0 308  SER   A CA  1 ? 
ATOM   885  C C   . SER   A 1 111 ? 12.207  -6.358  6.084   1.000 9.175  0 308  SER   A C   1 ? 
ATOM   886  O O   . SER   A 1 111 ? 13.145  -5.544  6.090   1.000 9.102  0 308  SER   A O   1 ? 
ATOM   887  C CB  . SER   A 1 111 ? 11.121  -6.956  3.873   1.000 9.523  0 308  SER   A CB  1 ? 
ATOM   888  O OG  . SER   A 1 111 ? 9.801   -6.945  4.380   1.000 9.808  0 308  SER   A OG  1 ? 
ATOM   889  N N   . THR   A 1 112 ? 11.312  -6.433  7.071   1.000 9.072  0 309  THR   A N   1 ? 
ATOM   890  C CA  . THR   A 1 112 ? 11.377  -5.583  8.290   1.000 9.000  0 309  THR   A CA  1 ? 
ATOM   891  C C   . THR   A 1 112 ? 12.707  -5.834  9.015   1.000 8.878  0 309  THR   A C   1 ? 
ATOM   892  O O   . THR   A 1 112 ? 13.387  -4.854  9.361   1.000 8.876  0 309  THR   A O   1 ? 
ATOM   893  C CB  . THR   A 1 112 ? 10.166  -5.814  9.201   1.000 9.241  0 309  THR   A CB  1 ? 
ATOM   894  O OG1 . THR   A 1 112 ? 8.987   -5.466  8.476   1.000 9.534  0 309  THR   A OG1 1 ? 
ATOM   895  C CG2 . THR   A 1 112 ? 10.225  -5.001  10.475  1.000 9.348  0 309  THR   A CG2 1 ? 
ATOM   896  N N   . ALA   A 1 113 ? 13.072  -7.096  9.250   1.000 8.622  0 310  ALA   A N   1 ? 
ATOM   897  C CA  . ALA   A 1 113 ? 14.321  -7.468  9.958   1.000 8.631  0 310  ALA   A CA  1 ? 
ATOM   898  C C   . ALA   A 1 113 ? 15.543  -6.976  9.174   1.000 8.671  0 310  ALA   A C   1 ? 
ATOM   899  O O   . ALA   A 1 113 ? 16.521  -6.544  9.811   1.000 8.480  0 310  ALA   A O   1 ? 
ATOM   900  C CB  . ALA   A 1 113 ? 14.376  -8.959  10.179  1.000 8.636  0 310  ALA   A CB  1 ? 
ATOM   901  N N   . SER   A 1 114 ? 15.508  -7.070  7.845   1.000 8.595  0 311  SER   A N   1 ? 
ATOM   902  C CA  A SER   A 1 114 ? 16.620  -6.626  6.965   0.500 8.562  0 311  SER   A CA  1 ? 
ATOM   903  C CA  B SER   A 1 114 ? 16.623  -6.627  6.966   0.500 8.716  0 311  SER   A CA  1 ? 
ATOM   904  C C   . SER   A 1 114 ? 16.792  -5.107  7.071   1.000 8.599  0 311  SER   A C   1 ? 
ATOM   905  O O   . SER   A 1 114 ? 17.939  -4.650  7.159   1.000 8.445  0 311  SER   A O   1 ? 
ATOM   906  C CB  A SER   A 1 114 ? 16.388  -7.063  5.548   0.500 8.538  0 311  SER   A CB  1 ? 
ATOM   907  C CB  B SER   A 1 114 ? 16.412  -7.057  5.539   0.500 8.866  0 311  SER   A CB  1 ? 
ATOM   908  O OG  A SER   A 1 114 ? 16.332  -8.479  5.470   0.500 8.474  0 311  SER   A OG  1 ? 
ATOM   909  O OG  B SER   A 1 114 ? 17.543  -6.732  4.741   0.500 9.247  0 311  SER   A OG  1 ? 
ATOM   910  N N   . GLY   A 1 115 ? 15.684  -4.364  7.070   1.000 8.499  0 312  GLY   A N   1 ? 
ATOM   911  C CA  . GLY   A 1 115 ? 15.708  -2.902  7.258   1.000 8.647  0 312  GLY   A CA  1 ? 
ATOM   912  C C   . GLY   A 1 115 ? 16.297  -2.540  8.609   1.000 8.636  0 312  GLY   A C   1 ? 
ATOM   913  O O   . GLY   A 1 115 ? 17.152  -1.641  8.667   1.000 8.688  0 312  GLY   A O   1 ? 
ATOM   914  N N   . LEU   A 1 116 ? 15.885  -3.235  9.671   1.000 8.719  0 313  LEU   A N   1 ? 
ATOM   915  C CA  . LEU   A 1 116 ? 16.352  -2.920  11.043  1.000 8.800  0 313  LEU   A CA  1 ? 
ATOM   916  C C   . LEU   A 1 116 ? 17.819  -3.332  11.196  1.000 8.820  0 313  LEU   A C   1 ? 
ATOM   917  O O   . LEU   A 1 116 ? 18.567  -2.570  11.825  1.000 8.820  0 313  LEU   A O   1 ? 
ATOM   918  C CB  . LEU   A 1 116 ? 15.467  -3.601  12.089  1.000 8.925  0 313  LEU   A CB  1 ? 
ATOM   919  C CG  . LEU   A 1 116 ? 15.694  -3.107  13.516  1.000 8.976  0 313  LEU   A CG  1 ? 
ATOM   920  C CD1 . LEU   A 1 116 ? 15.361  -1.627  13.645  1.000 9.109  0 313  LEU   A CD1 1 ? 
ATOM   921  C CD2 . LEU   A 1 116 ? 14.883  -3.919  14.514  1.000 9.067  0 313  LEU   A CD2 1 ? 
ATOM   922  N N   . ALA   A 1 117 ? 18.219  -4.479  10.643  1.000 9.020  0 314  ALA   A N   1 ? 
ATOM   923  C CA  . ALA   A 1 117 ? 19.627  -4.944  10.668  1.000 9.175  0 314  ALA   A CA  1 ? 
ATOM   924  C C   . ALA   A 1 117 ? 20.511  -3.891  9.988   1.000 9.401  0 314  ALA   A C   1 ? 
ATOM   925  O O   . ALA   A 1 117 ? 21.593  -3.582  10.523  1.000 9.549  0 314  ALA   A O   1 ? 
ATOM   926  C CB  . ALA   A 1 117 ? 19.753  -6.295  10.008  1.000 9.250  0 314  ALA   A CB  1 ? 
ATOM   927  N N   . HIS   A 1 118 ? 20.052  -3.327  8.871   1.000 9.605  0 315  HIS   A N   1 ? 
ATOM   928  C CA  . HIS   A 1 118 ? 20.787  -2.256  8.149   1.000 9.854  0 315  HIS   A CA  1 ? 
ATOM   929  C C   . HIS   A 1 118 ? 20.896  -1.007  9.033   1.000 9.817  0 315  HIS   A C   1 ? 
ATOM   930  O O   . HIS   A 1 118 ? 22.015  -0.485  9.179   1.000 9.746  0 315  HIS   A O   1 ? 
ATOM   931  C CB  . HIS   A 1 118 ? 20.146  -1.958  6.793   1.000 10.318 0 315  HIS   A CB  1 ? 
ATOM   932  C CG  . HIS   A 1 118 ? 20.823  -0.833  6.090   1.000 10.681 0 315  HIS   A CG  1 ? 
ATOM   933  N ND1 . HIS   A 1 118 ? 22.084  -0.958  5.535   1.000 11.215 0 315  HIS   A ND1 1 ? 
ATOM   934  C CD2 . HIS   A 1 118 ? 20.444  0.447   5.897   1.000 11.441 0 315  HIS   A CD2 1 ? 
ATOM   935  C CE1 . HIS   A 1 118 ? 22.428  0.194   4.994   1.000 11.483 0 315  HIS   A CE1 1 ? 
ATOM   936  N NE2 . HIS   A 1 118 ? 21.449  1.066   5.215   1.000 11.838 0 315  HIS   A NE2 1 ? 
ATOM   937  N N   . LEU   A 1 119 ? 19.792  -0.535  9.616   1.000 9.794  0 316  LEU   A N   1 ? 
ATOM   938  C CA  . LEU   A 1 119 ? 19.833  0.632   10.539  1.000 9.965  0 316  LEU   A CA  1 ? 
ATOM   939  C C   . LEU   A 1 119 ? 20.878  0.383   11.630  1.000 10.114 0 316  LEU   A C   1 ? 
ATOM   940  O O   . LEU   A 1 119 ? 21.725  1.263   11.855  1.000 10.159 0 316  LEU   A O   1 ? 
ATOM   941  C CB  . LEU   A 1 119 ? 18.457  0.861   11.167  1.000 10.157 0 316  LEU   A CB  1 ? 
ATOM   942  C CG  . LEU   A 1 119 ? 17.447  1.596   10.294  1.000 10.477 0 316  LEU   A CG  1 ? 
ATOM   943  C CD1 . LEU   A 1 119 ? 16.086  1.614   10.968  1.000 10.615 0 316  LEU   A CD1 1 ? 
ATOM   944  C CD2 . LEU   A 1 119 ? 17.902  3.019   9.995   1.000 10.511 0 316  LEU   A CD2 1 ? 
ATOM   945  N N   . HIS   A 1 120 ? 20.808  -0.782  12.274  1.000 10.232 0 317  HIS   A N   1 ? 
ATOM   946  C CA  . HIS   A 1 120 ? 21.634  -1.167  13.449  1.000 10.635 0 317  HIS   A CA  1 ? 
ATOM   947  C C   . HIS   A 1 120 ? 23.108  -1.344  13.068  1.000 11.523 0 317  HIS   A C   1 ? 
ATOM   948  O O   . HIS   A 1 120 ? 23.964  -1.181  13.958  1.000 12.124 0 317  HIS   A O   1 ? 
ATOM   949  C CB  . HIS   A 1 120 ? 21.073  -2.449  14.077  1.000 10.056 0 317  HIS   A CB  1 ? 
ATOM   950  C CG  . HIS   A 1 120 ? 19.834  -2.230  14.875  1.000 9.739  0 317  HIS   A CG  1 ? 
ATOM   951  N ND1 . HIS   A 1 120 ? 19.280  -3.223  15.655  1.000 9.546  0 317  HIS   A ND1 1 ? 
ATOM   952  C CD2 . HIS   A 1 120 ? 19.057  -1.137  15.037  1.000 9.409  0 317  HIS   A CD2 1 ? 
ATOM   953  C CE1 . HIS   A 1 120 ? 18.205  -2.757  16.252  1.000 9.383  0 317  HIS   A CE1 1 ? 
ATOM   954  N NE2 . HIS   A 1 120 ? 18.048  -1.474  15.897  1.000 9.321  0 317  HIS   A NE2 1 ? 
ATOM   955  N N   . MET   A 1 121 ? 23.391  -1.671  11.805  1.000 12.695 0 318  MET   A N   1 ? 
ATOM   956  C CA  A MET   A 1 121 ? 24.757  -2.046  11.350  0.500 13.279 0 318  MET   A CA  1 ? 
ATOM   957  C CA  B MET   A 1 121 ? 24.751  -2.045  11.329  0.500 13.306 0 318  MET   A CA  1 ? 
ATOM   958  C C   . MET   A 1 121 ? 25.625  -0.793  11.196  1.000 13.135 0 318  MET   A C   1 ? 
ATOM   959  O O   . MET   A 1 121 ? 25.260  0.099   10.411  1.000 12.944 0 318  MET   A O   1 ? 
ATOM   960  C CB  A MET   A 1 121 ? 24.718  -2.792  10.013  0.500 14.239 0 318  MET   A CB  1 ? 
ATOM   961  C CB  B MET   A 1 121 ? 24.674  -2.748  9.968   0.500 14.301 0 318  MET   A CB  1 ? 
ATOM   962  C CG  A MET   A 1 121 ? 26.082  -3.274  9.555   0.500 14.988 0 318  MET   A CG  1 ? 
ATOM   963  C CG  B MET   A 1 121 ? 26.029  -3.076  9.361   0.500 15.083 0 318  MET   A CG  1 ? 
ATOM   964  S SD  A MET   A 1 121 ? 26.003  -4.188  8.001   0.500 16.501 0 318  MET   A SD  1 ? 
ATOM   965  S SD  B MET   A 1 121 ? 27.007  -4.189  10.399  0.500 16.641 0 318  MET   A SD  1 ? 
ATOM   966  C CE  A MET   A 1 121 ? 27.705  -4.725  7.850   0.500 16.261 0 318  MET   A CE  1 ? 
ATOM   967  C CE  B MET   A 1 121 ? 26.070  -5.705  10.216  0.500 16.452 0 318  MET   A CE  1 ? 
ATOM   968  N N   . GLU   A 1 122 ? 26.744  -0.749  11.916  1.000 13.160 0 319  GLU   A N   1 ? 
ATOM   969  C CA  . GLU   A 1 122 ? 27.820  0.225   11.612  1.000 13.706 0 319  GLU   A CA  1 ? 
ATOM   970  C C   . GLU   A 1 122 ? 28.548  -0.295  10.370  1.000 13.382 0 319  GLU   A C   1 ? 
ATOM   971  O O   . GLU   A 1 122 ? 29.021  -1.446  10.400  1.000 13.412 0 319  GLU   A O   1 ? 
ATOM   972  C CB  . GLU   A 1 122 ? 28.801  0.399   12.772  1.000 14.493 0 319  GLU   A CB  1 ? 
ATOM   973  C CG  . GLU   A 1 122 ? 29.918  1.372   12.436  1.000 15.432 0 319  GLU   A CG  1 ? 
ATOM   974  C CD  . GLU   A 1 122 ? 30.995  1.547   13.488  1.000 16.622 0 319  GLU   A CD  1 ? 
ATOM   975  O OE1 . GLU   A 1 122 ? 31.091  0.694   14.390  1.000 17.679 0 319  GLU   A OE1 1 ? 
ATOM   976  O OE2 . GLU   A 1 122 ? 31.744  2.537   13.385  1.000 18.257 0 319  GLU   A OE2 1 ? 
ATOM   977  N N   . ILE   A 1 123 ? 28.587  0.491   9.297   1.000 13.304 0 320  ILE   A N   1 ? 
ATOM   978  C CA  . ILE   A 1 123 ? 29.452  0.197   8.120   1.000 13.961 0 320  ILE   A CA  1 ? 
ATOM   979  C C   . ILE   A 1 123 ? 30.730  0.995   8.342   1.000 14.695 0 320  ILE   A C   1 ? 
ATOM   980  O O   . ILE   A 1 123 ? 30.689  2.231   8.234   1.000 14.140 0 320  ILE   A O   1 ? 
ATOM   981  C CB  . ILE   A 1 123 ? 28.755  0.511   6.785   1.000 14.053 0 320  ILE   A CB  1 ? 
ATOM   982  C CG1 . ILE   A 1 123 ? 27.465  -0.301  6.641   1.000 14.141 0 320  ILE   A CG1 1 ? 
ATOM   983  C CG2 . ILE   A 1 123 ? 29.705  0.274   5.619   1.000 14.152 0 320  ILE   A CG2 1 ? 
ATOM   984  C CD1 . ILE   A 1 123 ? 26.595  0.110   5.481   1.000 14.309 0 320  ILE   A CD1 1 ? 
ATOM   985  N N   . VAL   A 1 124 ? 31.790  0.296   8.739   1.000 15.535 0 321  VAL   A N   1 ? 
ATOM   986  C CA  . VAL   A 1 124 ? 33.052  0.907   9.235   1.000 17.312 0 321  VAL   A CA  1 ? 
ATOM   987  C C   . VAL   A 1 124 ? 33.805  1.487   8.040   1.000 18.498 0 321  VAL   A C   1 ? 
ATOM   988  O O   . VAL   A 1 124 ? 33.907  0.807   7.000   1.000 19.221 0 321  VAL   A O   1 ? 
ATOM   989  C CB  . VAL   A 1 124 ? 33.897  -0.115  10.017  1.000 17.742 0 321  VAL   A CB  1 ? 
ATOM   990  C CG1 . VAL   A 1 124 ? 35.315  0.381   10.257  1.000 18.145 0 321  VAL   A CG1 1 ? 
ATOM   991  C CG2 . VAL   A 1 124 ? 33.225  -0.480  11.329  1.000 17.886 0 321  VAL   A CG2 1 ? 
ATOM   992  N N   . GLY   A 1 125 ? 34.278  2.719   8.203   1.000 19.652 0 322  GLY   A N   1 ? 
ATOM   993  C CA  . GLY   A 1 125 ? 35.166  3.397   7.249   1.000 20.587 0 322  GLY   A CA  1 ? 
ATOM   994  C C   . GLY   A 1 125 ? 35.416  4.821   7.686   1.000 21.703 0 322  GLY   A C   1 ? 
ATOM   995  O O   . GLY   A 1 125 ? 34.693  5.313   8.581   1.000 22.455 0 322  GLY   A O   1 ? 
ATOM   996  N N   . THR   A 1 126 ? 36.407  5.462   7.071   1.000 22.782 0 323  THR   A N   1 ? 
ATOM   997  C CA  . THR   A 1 126 ? 36.594  6.932   7.095   1.000 23.402 0 323  THR   A CA  1 ? 
ATOM   998  C C   . THR   A 1 126 ? 35.302  7.580   6.571   1.000 23.379 0 323  THR   A C   1 ? 
ATOM   999  O O   . THR   A 1 126 ? 35.017  8.724   6.974   1.000 24.395 0 323  THR   A O   1 ? 
ATOM   1000 C CB  . THR   A 1 126 ? 37.850  7.316   6.302   1.000 23.667 0 323  THR   A CB  1 ? 
ATOM   1001 O OG1 . THR   A 1 126 ? 37.685  6.832   4.969   1.000 23.779 0 323  THR   A OG1 1 ? 
ATOM   1002 C CG2 . THR   A 1 126 ? 39.119  6.741   6.897   1.000 23.786 0 323  THR   A CG2 1 ? 
ATOM   1003 N N   . GLN   A 1 127 ? 34.542  6.853   5.738   1.000 23.425 0 324  GLN   A N   1 ? 
ATOM   1004 C CA  . GLN   A 1 127 ? 33.296  7.322   5.065   1.000 22.726 0 324  GLN   A CA  1 ? 
ATOM   1005 C C   . GLN   A 1 127 ? 32.129  6.363   5.332   1.000 21.574 0 324  GLN   A C   1 ? 
ATOM   1006 O O   . GLN   A 1 127 ? 31.298  6.156   4.418   1.000 22.102 0 324  GLN   A O   1 ? 
ATOM   1007 C CB  . GLN   A 1 127 ? 33.540  7.396   3.562   1.000 23.695 0 324  GLN   A CB  1 ? 
ATOM   1008 C CG  . GLN   A 1 127 ? 34.693  8.315   3.200   1.000 24.267 0 324  GLN   A CG  1 ? 
ATOM   1009 C CD  . GLN   A 1 127 ? 35.208  8.073   1.806   1.000 24.827 0 324  GLN   A CD  1 ? 
ATOM   1010 O OE1 . GLN   A 1 127 ? 34.748  7.184   1.089   1.000 25.284 0 324  GLN   A OE1 1 ? 
ATOM   1011 N NE2 . GLN   A 1 127 ? 36.189  8.869   1.420   1.000 24.551 0 324  GLN   A NE2 1 ? 
ATOM   1012 N N   . GLY   A 1 128 ? 32.052  5.807   6.539   1.000 19.742 0 325  GLY   A N   1 ? 
ATOM   1013 C CA  . GLY   A 1 128 ? 31.095  4.735   6.863   1.000 17.744 0 325  GLY   A CA  1 ? 
ATOM   1014 C C   . GLY   A 1 128 ? 29.707  5.256   7.191   1.000 16.222 0 325  GLY   A C   1 ? 
ATOM   1015 O O   . GLY   A 1 128 ? 29.446  6.476   7.051   1.000 16.957 0 325  GLY   A O   1 ? 
ATOM   1016 N N   . LYS   A 1 129 ? 28.838  4.333   7.593   1.000 13.859 0 326  LYS   A N   1 ? 
ATOM   1017 C CA  . LYS   A 1 129 ? 27.481  4.609   8.116   1.000 12.191 0 326  LYS   A CA  1 ? 
ATOM   1018 C C   . LYS   A 1 129 ? 27.498  4.324   9.610   1.000 11.155 0 326  LYS   A C   1 ? 
ATOM   1019 O O   . LYS   A 1 129 ? 27.870  3.221   10.013  1.000 10.739 0 326  LYS   A O   1 ? 
ATOM   1020 C CB  . LYS   A 1 129 ? 26.461  3.711   7.415   1.000 11.942 0 326  LYS   A CB  1 ? 
ATOM   1021 C CG  . LYS   A 1 129 ? 25.037  3.850   7.925   1.000 11.814 0 326  LYS   A CG  1 ? 
ATOM   1022 C CD  . LYS   A 1 129 ? 24.155  2.705   7.503   1.000 11.832 0 326  LYS   A CD  1 ? 
ATOM   1023 C CE  . LYS   A 1 129 ? 22.986  2.483   8.434   1.000 11.635 0 326  LYS   A CE  1 ? 
ATOM   1024 N NZ  . LYS   A 1 129 ? 23.432  2.004   9.766   1.000 11.351 0 326  LYS   A NZ  1 ? 
ATOM   1025 N N   . PRO   A 1 130 ? 27.090  5.278   10.478  1.000 10.216 0 327  PRO   A N   1 ? 
ATOM   1026 C CA  . PRO   A 1 130 ? 26.978  4.988   11.904  1.000 9.941  0 327  PRO   A CA  1 ? 
ATOM   1027 C C   . PRO   A 1 130 ? 25.824  4.009   12.152  1.000 9.367  0 327  PRO   A C   1 ? 
ATOM   1028 O O   . PRO   A 1 130 ? 24.877  4.000   11.377  1.000 9.365  0 327  PRO   A O   1 ? 
ATOM   1029 C CB  . PRO   A 1 130 ? 26.691  6.358   12.530  1.000 10.056 0 327  PRO   A CB  1 ? 
ATOM   1030 C CG  . PRO   A 1 130 ? 25.986  7.113   11.422  1.000 10.305 0 327  PRO   A CG  1 ? 
ATOM   1031 C CD  . PRO   A 1 130 ? 26.670  6.652   10.152  1.000 10.269 0 327  PRO   A CD  1 ? 
ATOM   1032 N N   . ALA   A 1 131 ? 25.931  3.205   13.207  1.000 9.124  0 328  ALA   A N   1 ? 
ATOM   1033 C CA  . ALA   A 1 131 ? 24.794  2.424   13.734  1.000 8.905  0 328  ALA   A CA  1 ? 
ATOM   1034 C C   . ALA   A 1 131 ? 23.686  3.405   14.130  1.000 8.629  0 328  ALA   A C   1 ? 
ATOM   1035 O O   . ALA   A 1 131 ? 23.997  4.501   14.635  1.000 8.623  0 328  ALA   A O   1 ? 
ATOM   1036 C CB  . ALA   A 1 131 ? 25.222  1.560   14.890  1.000 8.985  0 328  ALA   A CB  1 ? 
ATOM   1037 N N   . ILE   A 1 132 ? 22.437  3.031   13.861  1.000 8.412  0 329  ILE   A N   1 ? 
ATOM   1038 C CA  . ILE   A 1 132 ? 21.229  3.860   14.132  1.000 8.478  0 329  ILE   A CA  1 ? 
ATOM   1039 C C   . ILE   A 1 132 ? 20.214  2.982   14.863  1.000 8.234  0 329  ILE   A C   1 ? 
ATOM   1040 O O   . ILE   A 1 132 ? 19.993  1.853   14.410  1.000 8.329  0 329  ILE   A O   1 ? 
ATOM   1041 C CB  . ILE   A 1 132 ? 20.645  4.423   12.819  1.000 8.631  0 329  ILE   A CB  1 ? 
ATOM   1042 C CG1 . ILE   A 1 132 ? 21.689  5.194   12.003  1.000 8.911  0 329  ILE   A CG1 1 ? 
ATOM   1043 C CG2 . ILE   A 1 132 ? 19.409  5.264   13.103  1.000 8.749  0 329  ILE   A CG2 1 ? 
ATOM   1044 C CD1 . ILE   A 1 132 ? 21.257  5.515   10.594  1.000 9.151  0 329  ILE   A CD1 1 ? 
ATOM   1045 N N   . ALA   A 1 133 ? 19.625  3.490   15.946  1.000 8.099  0 330  ALA   A N   1 ? 
ATOM   1046 C CA  . ALA   A 1 133 ? 18.449  2.882   16.609  1.000 8.082  0 330  ALA   A CA  1 ? 
ATOM   1047 C C   . ALA   A 1 133 ? 17.236  3.771   16.326  1.000 8.091  0 330  ALA   A C   1 ? 
ATOM   1048 O O   . ALA   A 1 133 ? 17.374  5.003   16.372  1.000 8.075  0 330  ALA   A O   1 ? 
ATOM   1049 C CB  . ALA   A 1 133 ? 18.688  2.701   18.085  1.000 8.109  0 330  ALA   A CB  1 ? 
ATOM   1050 N N   . HIS   A 1 134 ? 16.098  3.155   16.016  1.000 8.148  0 331  HIS   A N   1 ? 
ATOM   1051 C CA  . HIS   A 1 134 ? 14.872  3.843   15.534  1.000 8.439  0 331  HIS   A CA  1 ? 
ATOM   1052 C C   . HIS   A 1 134 ? 14.145  4.530   16.699  1.000 8.765  0 331  HIS   A C   1 ? 
ATOM   1053 O O   . HIS   A 1 134 ? 13.782  5.713   16.545  1.000 8.479  0 331  HIS   A O   1 ? 
ATOM   1054 C CB  . HIS   A 1 134 ? 13.984  2.821   14.824  1.000 8.283  0 331  HIS   A CB  1 ? 
ATOM   1055 C CG  . HIS   A 1 134 ? 12.806  3.420   14.137  1.000 8.181  0 331  HIS   A CG  1 ? 
ATOM   1056 N ND1 . HIS   A 1 134 ? 11.709  3.893   14.830  1.000 8.201  0 331  HIS   A ND1 1 ? 
ATOM   1057 C CD2 . HIS   A 1 134 ? 12.550  3.625   12.828  1.000 8.309  0 331  HIS   A CD2 1 ? 
ATOM   1058 C CE1 . HIS   A 1 134 ? 10.828  4.366   13.975  1.000 8.258  0 331  HIS   A CE1 1 ? 
ATOM   1059 N NE2 . HIS   A 1 134 ? 11.314  4.203   12.743  1.000 8.320  0 331  HIS   A NE2 1 ? 
ATOM   1060 N N   . ARG   A 1 135 ? 13.891  3.766   17.771  1.000 9.181  0 332  ARG   A N   1 ? 
ATOM   1061 C CA  A ARG   A 1 135 ? 13.294  4.212   19.065  0.500 9.655  0 332  ARG   A CA  1 ? 
ATOM   1062 C CA  B ARG   A 1 135 ? 13.295  4.221   19.064  0.500 9.540  0 332  ARG   A CA  1 ? 
ATOM   1063 C C   . ARG   A 1 135 ? 11.769  4.361   18.970  1.000 9.734  0 332  ARG   A C   1 ? 
ATOM   1064 O O   . ARG   A 1 135 ? 11.158  4.685   20.002  1.000 10.087 0 332  ARG   A O   1 ? 
ATOM   1065 C CB  A ARG   A 1 135 ? 13.935  5.513   19.558  0.500 10.056 0 332  ARG   A CB  1 ? 
ATOM   1066 C CB  B ARG   A 1 135 ? 13.914  5.537   19.549  0.500 9.782  0 332  ARG   A CB  1 ? 
ATOM   1067 C CG  A ARG   A 1 135 ? 15.414  5.380   19.890  0.500 10.407 0 332  ARG   A CG  1 ? 
ATOM   1068 C CG  B ARG   A 1 135 ? 15.370  5.422   19.978  0.500 9.970  0 332  ARG   A CG  1 ? 
ATOM   1069 C CD  A ARG   A 1 135 ? 15.999  6.669   20.427  0.500 10.857 0 332  ARG   A CD  1 ? 
ATOM   1070 C CD  B ARG   A 1 135 ? 15.742  6.479   20.999  0.500 10.241 0 332  ARG   A CD  1 ? 
ATOM   1071 N NE  A ARG   A 1 135 ? 15.391  7.077   21.682  0.500 11.295 0 332  ARG   A NE  1 ? 
ATOM   1072 N NE  B ARG   A 1 135 ? 15.468  7.818   20.503  0.500 10.544 0 332  ARG   A NE  1 ? 
ATOM   1073 C CZ  A ARG   A 1 135 ? 15.243  8.337   22.069  0.500 11.791 0 332  ARG   A CZ  1 ? 
ATOM   1074 C CZ  B ARG   A 1 135 ? 15.432  8.915   21.251  0.500 10.832 0 332  ARG   A CZ  1 ? 
ATOM   1075 N NH1 A ARG   A 1 135 ? 15.640  9.323   21.284  0.500 12.033 0 332  ARG   A NH1 1 ? 
ATOM   1076 N NH1 B ARG   A 1 135 ? 15.653  8.845   22.553  0.500 11.034 0 332  ARG   A NH1 1 ? 
ATOM   1077 N NH2 A ARG   A 1 135 ? 14.694  8.607   23.239  0.500 11.936 0 332  ARG   A NH2 1 ? 
ATOM   1078 N NH2 B ARG   A 1 135 ? 15.185  10.083  20.686  0.500 10.878 0 332  ARG   A NH2 1 ? 
ATOM   1079 N N   . ASP   A 1 136 ? 11.159  4.108   17.814  1.000 9.729  0 333  ASP   A N   1 ? 
ATOM   1080 C CA  . ASP   A 1 136 ? 9.677   4.197   17.710  1.000 9.826  0 333  ASP   A CA  1 ? 
ATOM   1081 C C   . ASP   A 1 136 ? 9.148   3.209   16.666  1.000 9.390  0 333  ASP   A C   1 ? 
ATOM   1082 O O   . ASP   A 1 136 ? 8.201   3.559   15.946  1.000 9.560  0 333  ASP   A O   1 ? 
ATOM   1083 C CB  . ASP   A 1 136 ? 9.233   5.630   17.405  1.000 10.656 0 333  ASP   A CB  1 ? 
ATOM   1084 C CG  . ASP   A 1 136 ? 7.735   5.840   17.524  1.000 11.412 0 333  ASP   A CG  1 ? 
ATOM   1085 O OD1 . ASP   A 1 136 ? 7.095   5.092   18.297  1.000 11.922 0 333  ASP   A OD1 1 ? 
ATOM   1086 O OD2 . ASP   A 1 136 ? 7.219   6.735   16.823  1.000 13.049 0 333  ASP   A OD2 1 ? 
ATOM   1087 N N   . LEU   A 1 137 ? 9.693   1.996   16.617  1.000 9.112  0 334  LEU   A N   1 ? 
ATOM   1088 C CA  . LEU   A 1 137 ? 9.265   0.987   15.618  1.000 9.088  0 334  LEU   A CA  1 ? 
ATOM   1089 C C   . LEU   A 1 137 ? 7.873   0.473   15.994  1.000 8.635  0 334  LEU   A C   1 ? 
ATOM   1090 O O   . LEU   A 1 137 ? 7.640   0.160   17.172  1.000 8.340  0 334  LEU   A O   1 ? 
ATOM   1091 C CB  . LEU   A 1 137 ? 10.283  -0.151  15.545  1.000 9.528  0 334  LEU   A CB  1 ? 
ATOM   1092 C CG  . LEU   A 1 137 ? 10.118  -1.082  14.347  1.000 10.008 0 334  LEU   A CG  1 ? 
ATOM   1093 C CD1 . LEU   A 1 137 ? 10.305  -0.330  13.036  1.000 10.273 0 334  LEU   A CD1 1 ? 
ATOM   1094 C CD2 . LEU   A 1 137 ? 11.090  -2.247  14.437  1.000 10.132 0 334  LEU   A CD2 1 ? 
ATOM   1095 N N   . LYS   A 1 138 ? 6.976   0.403   15.016  1.000 8.332  0 335  LYS   A N   1 ? 
ATOM   1096 C CA  . LYS   A 1 138 ? 5.587   -0.096  15.189  1.000 8.465  0 335  LYS   A CA  1 ? 
ATOM   1097 C C   . LYS   A 1 138 ? 5.011   -0.358  13.799  1.000 8.297  0 335  LYS   A C   1 ? 
ATOM   1098 O O   . LYS   A 1 138 ? 5.593   0.114   12.808  1.000 8.224  0 335  LYS   A O   1 ? 
ATOM   1099 C CB  . LYS   A 1 138 ? 4.740   0.907   15.978  1.000 8.589  0 335  LYS   A CB  1 ? 
ATOM   1100 C CG  . LYS   A 1 138 ? 4.688   2.319   15.409  1.000 8.842  0 335  LYS   A CG  1 ? 
ATOM   1101 C CD  . LYS   A 1 138 ? 3.802   3.249   16.213  1.000 9.182  0 335  LYS   A CD  1 ? 
ATOM   1102 C CE  . LYS   A 1 138 ? 3.825   4.666   15.686  1.000 9.556  0 335  LYS   A CE  1 ? 
ATOM   1103 N NZ  . LYS   A 1 138 ? 3.013   5.581   16.520  1.000 9.945  0 335  LYS   A NZ  1 ? 
ATOM   1104 N N   . SER   A 1 139 ? 3.895   -1.075  13.714  1.000 8.202  0 336  SER   A N   1 ? 
ATOM   1105 C CA  . SER   A 1 139 ? 3.268   -1.418  12.415  1.000 8.309  0 336  SER   A CA  1 ? 
ATOM   1106 C C   . SER   A 1 139 ? 2.808   -0.139  11.698  1.000 8.314  0 336  SER   A C   1 ? 
ATOM   1107 O O   . SER   A 1 139 ? 2.761   -0.150  10.456  1.000 8.280  0 336  SER   A O   1 ? 
ATOM   1108 C CB  . SER   A 1 139 ? 2.154   -2.412  12.582  1.000 8.346  0 336  SER   A CB  1 ? 
ATOM   1109 O OG  . SER   A 1 139 ? 1.180   -1.937  13.487  1.000 8.308  0 336  SER   A OG  1 ? 
ATOM   1110 N N   . LYS   A 1 140 ? 2.510   0.941   12.428  1.000 8.448  0 337  LYS   A N   1 ? 
ATOM   1111 C CA  . LYS   A 1 140 ? 2.031   2.207   11.809  1.000 8.913  0 337  LYS   A CA  1 ? 
ATOM   1112 C C   . LYS   A 1 140 ? 3.175   2.983   11.136  1.000 8.788  0 337  LYS   A C   1 ? 
ATOM   1113 O O   . LYS   A 1 140 ? 2.843   3.867   10.341  1.000 9.260  0 337  LYS   A O   1 ? 
ATOM   1114 C CB  . LYS   A 1 140 ? 1.284   3.065   12.834  1.000 9.555  0 337  LYS   A CB  1 ? 
ATOM   1115 C CG  . LYS   A 1 140 ? -0.131  2.587   13.132  1.000 10.282 0 337  LYS   A CG  1 ? 
ATOM   1116 C CD  . LYS   A 1 140 ? -0.803  3.315   14.276  1.000 11.208 0 337  LYS   A CD  1 ? 
ATOM   1117 C CE  . LYS   A 1 140 ? -2.015  2.576   14.805  1.000 11.985 0 337  LYS   A CE  1 ? 
ATOM   1118 N NZ  . LYS   A 1 140 ? -2.580  3.226   16.012  1.000 12.879 0 337  LYS   A NZ  1 ? 
ATOM   1119 N N   . ASN   A 1 141 ? 4.457   2.681   11.385  1.000 8.499  0 338  ASN   A N   1 ? 
ATOM   1120 C CA  A ASN   A 1 141 ? 5.517   3.449   10.660  0.500 8.309  0 338  ASN   A CA  1 ? 
ATOM   1121 C CA  B ASN   A 1 141 ? 5.652   3.388   10.844  0.500 8.579  0 338  ASN   A CA  1 ? 
ATOM   1122 C C   . ASN   A 1 141 ? 6.400   2.506   9.835   1.000 8.345  0 338  ASN   A C   1 ? 
ATOM   1123 O O   . ASN   A 1 141 ? 7.498   2.921   9.408   1.000 8.684  0 338  ASN   A O   1 ? 
ATOM   1124 C CB  A ASN   A 1 141 ? 6.303   4.393   11.569  0.500 8.113  0 338  ASN   A CB  1 ? 
ATOM   1125 C CB  B ASN   A 1 141 ? 6.629   3.767   11.962  0.500 8.742  0 338  ASN   A CB  1 ? 
ATOM   1126 C CG  A ASN   A 1 141 ? 6.908   3.711   12.771  0.500 7.945  0 338  ASN   A CG  1 ? 
ATOM   1127 C CG  B ASN   A 1 141 ? 6.133   4.916   12.807  0.500 8.961  0 338  ASN   A CG  1 ? 
ATOM   1128 O OD1 A ASN   A 1 141 ? 7.171   2.513   12.746  0.500 7.815  0 338  ASN   A OD1 1 ? 
ATOM   1129 O OD1 B ASN   A 1 141 ? 5.199   5.611   12.416  0.500 9.207  0 338  ASN   A OD1 1 ? 
ATOM   1130 N ND2 A ASN   A 1 141 ? 7.139   4.477   13.822  0.500 7.977  0 338  ASN   A ND2 1 ? 
ATOM   1131 N ND2 B ASN   A 1 141 ? 6.764   5.131   13.950  0.500 9.030  0 338  ASN   A ND2 1 ? 
ATOM   1132 N N   . ILE   A 1 142 ? 5.873   1.328   9.525   1.000 7.984  0 339  ILE   A N   1 ? 
ATOM   1133 C CA  . ILE   A 1 142 ? 6.435   0.436   8.477   1.000 8.002  0 339  ILE   A CA  1 ? 
ATOM   1134 C C   . ILE   A 1 142 ? 5.473   0.521   7.293   1.000 8.048  0 339  ILE   A C   1 ? 
ATOM   1135 O O   . ILE   A 1 142 ? 4.258   0.499   7.536   1.000 8.071  0 339  ILE   A O   1 ? 
ATOM   1136 C CB  . ILE   A 1 142 ? 6.609   -0.997  9.011   1.000 7.953  0 339  ILE   A CB  1 ? 
ATOM   1137 C CG1 . ILE   A 1 142 ? 7.563   -1.035  10.208  1.000 8.110  0 339  ILE   A CG1 1 ? 
ATOM   1138 C CG2 . ILE   A 1 142 ? 7.060   -1.934  7.904   1.000 7.970  0 339  ILE   A CG2 1 ? 
ATOM   1139 C CD1 . ILE   A 1 142 ? 7.459   -2.293  11.035  1.000 8.169  0 339  ILE   A CD1 1 ? 
ATOM   1140 N N   . LEU   A 1 143 ? 5.998   0.665   6.077   1.000 8.083  0 340  LEU   A N   1 ? 
ATOM   1141 C CA  . LEU   A 1 143 ? 5.188   0.779   4.837   1.000 8.480  0 340  LEU   A CA  1 ? 
ATOM   1142 C C   . LEU   A 1 143 ? 5.334   -0.507  4.026   1.000 8.676  0 340  LEU   A C   1 ? 
ATOM   1143 O O   . LEU   A 1 143 ? 6.415   -1.112  4.064   1.000 9.443  0 340  LEU   A O   1 ? 
ATOM   1144 C CB  . LEU   A 1 143 ? 5.659   1.993   4.034   1.000 8.554  0 340  LEU   A CB  1 ? 
ATOM   1145 C CG  . LEU   A 1 143 ? 5.494   3.339   4.736   1.000 8.777  0 340  LEU   A CG  1 ? 
ATOM   1146 C CD1 . LEU   A 1 143 ? 6.306   4.406   4.024   1.000 8.900  0 340  LEU   A CD1 1 ? 
ATOM   1147 C CD2 . LEU   A 1 143 ? 4.031   3.749   4.819   1.000 8.964  0 340  LEU   A CD2 1 ? 
ATOM   1148 N N   . VAL   A 1 144 ? 4.277   -0.903  3.318   1.000 8.738  0 341  VAL   A N   1 ? 
ATOM   1149 C CA  . VAL   A 1 144 ? 4.286   -2.127  2.468   1.000 9.059  0 341  VAL   A CA  1 ? 
ATOM   1150 C C   . VAL   A 1 144 ? 4.408   -1.677  1.010   1.000 9.547  0 341  VAL   A C   1 ? 
ATOM   1151 O O   . VAL   A 1 144 ? 3.555   -0.904  0.546   1.000 9.431  0 341  VAL   A O   1 ? 
ATOM   1152 C CB  . VAL   A 1 144 ? 3.045   -3.006  2.712   1.000 8.985  0 341  VAL   A CB  1 ? 
ATOM   1153 C CG1 . VAL   A 1 144 ? 3.088   -4.274  1.871   1.000 9.098  0 341  VAL   A CG1 1 ? 
ATOM   1154 C CG2 . VAL   A 1 144 ? 2.879   -3.353  4.187   1.000 8.925  0 341  VAL   A CG2 1 ? 
ATOM   1155 N N   . LYS   A 1 145 ? 5.454   -2.133  0.327   1.000 10.162 0 342  LYS   A N   1 ? 
ATOM   1156 C CA  . LYS   A 1 145 ? 5.679   -1.830  -1.108  1.000 10.958 0 342  LYS   A CA  1 ? 
ATOM   1157 C C   . LYS   A 1 145 ? 4.801   -2.737  -1.972  1.000 11.552 0 342  LYS   A C   1 ? 
ATOM   1158 O O   . LYS   A 1 145 ? 4.288   -3.749  -1.454  1.000 11.488 0 342  LYS   A O   1 ? 
ATOM   1159 C CB  . LYS   A 1 145 ? 7.145   -2.049  -1.472  1.000 11.400 0 342  LYS   A CB  1 ? 
ATOM   1160 C CG  . LYS   A 1 145 ? 8.143   -1.222  -0.684  1.000 11.856 0 342  LYS   A CG  1 ? 
ATOM   1161 C CD  . LYS   A 1 145 ? 9.482   -1.200  -1.377  1.000 12.488 0 342  LYS   A CD  1 ? 
ATOM   1162 C CE  . LYS   A 1 145 ? 10.555  -0.485  -0.592  1.000 12.993 0 342  LYS   A CE  1 ? 
ATOM   1163 N NZ  . LYS   A 1 145 ? 11.833  -0.463  -1.341  1.000 13.645 0 342  LYS   A NZ  1 ? 
ATOM   1164 N N   . LYS   A 1 146 ? 4.674   -2.404  -3.259  1.000 12.429 0 343  LYS   A N   1 ? 
ATOM   1165 C CA  . LYS   A 1 146 ? 3.856   -3.172  -4.235  1.000 13.338 0 343  LYS   A CA  1 ? 
ATOM   1166 C C   . LYS   A 1 146 ? 4.343   -4.626  -4.316  1.000 13.278 0 343  LYS   A C   1 ? 
ATOM   1167 O O   . LYS   A 1 146 ? 3.496   -5.505  -4.542  1.000 13.689 0 343  LYS   A O   1 ? 
ATOM   1168 C CB  . LYS   A 1 146 ? 3.895   -2.520  -5.619  1.000 14.143 0 343  LYS   A CB  1 ? 
ATOM   1169 C CG  . LYS   A 1 146 ? 2.922   -3.128  -6.619  1.000 15.277 0 343  LYS   A CG  1 ? 
ATOM   1170 C CD  . LYS   A 1 146 ? 2.592   -2.226  -7.782  1.000 16.103 0 343  LYS   A CD  1 ? 
ATOM   1171 C CE  . LYS   A 1 146 ? 1.457   -2.770  -8.623  1.000 16.853 0 343  LYS   A CE  1 ? 
ATOM   1172 N NZ  . LYS   A 1 146 ? 1.205   -1.934  -9.820  1.000 17.611 0 343  LYS   A NZ  1 ? 
ATOM   1173 N N   . ASN   A 1 147 ? 5.644   -4.876  -4.124  1.000 13.147 0 344  ASN   A N   1 ? 
ATOM   1174 C CA  . ASN   A 1 147 ? 6.250   -6.232  -4.246  1.000 13.390 0 344  ASN   A CA  1 ? 
ATOM   1175 C C   . ASN   A 1 147 ? 6.057   -7.040  -2.953  1.000 13.308 0 344  ASN   A C   1 ? 
ATOM   1176 O O   . ASN   A 1 147 ? 6.596   -8.162  -2.889  1.000 13.965 0 344  ASN   A O   1 ? 
ATOM   1177 C CB  . ASN   A 1 147 ? 7.726   -6.162  -4.655  1.000 13.565 0 344  ASN   A CB  1 ? 
ATOM   1178 C CG  . ASN   A 1 147 ? 8.646   -5.631  -3.574  1.000 13.893 0 344  ASN   A CG  1 ? 
ATOM   1179 O OD1 . ASN   A 1 147 ? 8.203   -5.244  -2.494  1.000 13.696 0 344  ASN   A OD1 1 ? 
ATOM   1180 N ND2 . ASN   A 1 147 ? 9.938   -5.608  -3.856  1.000 14.246 0 344  ASN   A ND2 1 ? 
ATOM   1181 N N   . GLY   A 1 148 ? 5.331   -6.505  -1.964  1.000 12.820 0 345  GLY   A N   1 ? 
ATOM   1182 C CA  . GLY   A 1 148 ? 4.958   -7.231  -0.735  1.000 12.495 0 345  GLY   A CA  1 ? 
ATOM   1183 C C   . GLY   A 1 148 ? 6.075   -7.259  0.297   1.000 12.164 0 345  GLY   A C   1 ? 
ATOM   1184 O O   . GLY   A 1 148 ? 5.975   -8.054  1.252   1.000 12.354 0 345  GLY   A O   1 ? 
ATOM   1185 N N   . THR   A 1 149 ? 7.114   -6.439  0.119   1.000 11.815 0 346  THR   A N   1 ? 
ATOM   1186 C CA  . THR   A 1 149 ? 8.188   -6.228  1.123   1.000 11.650 0 346  THR   A CA  1 ? 
ATOM   1187 C C   . THR   A 1 149 ? 7.921   -4.912  1.856   1.000 11.196 0 346  THR   A C   1 ? 
ATOM   1188 O O   . THR   A 1 149 ? 7.158   -4.073  1.334   1.000 11.329 0 346  THR   A O   1 ? 
ATOM   1189 C CB  . THR   A 1 149 ? 9.590   -6.232  0.499   1.000 12.018 0 346  THR   A CB  1 ? 
ATOM   1190 O OG1 . THR   A 1 149 ? 9.732   -5.070  -0.318  1.000 12.774 0 346  THR   A OG1 1 ? 
ATOM   1191 C CG2 . THR   A 1 149 ? 9.871   -7.476  -0.316  1.000 12.295 0 346  THR   A CG2 1 ? 
ATOM   1192 N N   . CYS   A 1 150 ? 8.543   -4.748  3.020   1.000 10.775 0 347  CYS   A N   1 ? 
ATOM   1193 C CA  . CYS   A 1 150 ? 8.352   -3.594  3.930   1.000 10.732 0 347  CYS   A CA  1 ? 
ATOM   1194 C C   . CYS   A 1 150 ? 9.526   -2.626  3.817   1.000 10.050 0 347  CYS   A C   1 ? 
ATOM   1195 O O   . CYS   A 1 150 ? 10.645  -3.060  3.491   1.000 9.973  0 347  CYS   A O   1 ? 
ATOM   1196 C CB  . CYS   A 1 150 ? 8.242   -4.060  5.374   1.000 11.104 0 347  CYS   A CB  1 ? 
ATOM   1197 S SG  . CYS   A 1 150 ? 6.720   -4.981  5.701   1.000 12.278 0 347  CYS   A SG  1 ? 
ATOM   1198 N N   . CYS   A 1 151 ? 9.284   -1.357  4.130   1.000 9.434  0 348  CYS   A N   1 ? 
ATOM   1199 C CA  . CYS   A 1 151 ? 10.370  -0.387  4.405   1.000 9.274  0 348  CYS   A CA  1 ? 
ATOM   1200 C C   . CYS   A 1 151 ? 10.013  0.449   5.634   1.000 8.933  0 348  CYS   A C   1 ? 
ATOM   1201 O O   . CYS   A 1 151 ? 8.827   0.736   5.867   1.000 9.054  0 348  CYS   A O   1 ? 
ATOM   1202 C CB  . CYS   A 1 151 ? 10.702  0.470   3.190   1.000 9.364  0 348  CYS   A CB  1 ? 
ATOM   1203 S SG  . CYS   A 1 151 ? 9.347   1.518   2.604   1.000 9.877  0 348  CYS   A SG  1 ? 
ATOM   1204 N N   . ILE   A 1 152 ? 11.030  0.781   6.421   1.000 8.631  0 349  ILE   A N   1 ? 
ATOM   1205 C CA  . ILE   A 1 152 ? 10.874  1.493   7.718   1.000 8.553  0 349  ILE   A CA  1 ? 
ATOM   1206 C C   . ILE   A 1 152 ? 10.883  3.003   7.453   1.000 8.461  0 349  ILE   A C   1 ? 
ATOM   1207 O O   . ILE   A 1 152 ? 11.731  3.466   6.670   1.000 8.445  0 349  ILE   A O   1 ? 
ATOM   1208 C CB  . ILE   A 1 152 ? 11.975  1.037   8.691   1.000 8.619  0 349  ILE   A CB  1 ? 
ATOM   1209 C CG1 . ILE   A 1 152 ? 11.878  -0.469  8.955   1.000 8.786  0 349  ILE   A CG1 1 ? 
ATOM   1210 C CG2 . ILE   A 1 152 ? 11.927  1.844   9.978   1.000 8.699  0 349  ILE   A CG2 1 ? 
ATOM   1211 C CD1 . ILE   A 1 152 ? 13.088  -1.061  9.641   1.000 8.919  0 349  ILE   A CD1 1 ? 
ATOM   1212 N N   . ALA   A 1 153 ? 9.959   3.730   8.083   1.000 8.445  0 350  ALA   A N   1 ? 
ATOM   1213 C CA  . ALA   A 1 153 ? 9.792   5.194   7.949   1.000 8.776  0 350  ALA   A CA  1 ? 
ATOM   1214 C C   . ALA   A 1 153 ? 9.753   5.846   9.337   1.000 8.967  0 350  ALA   A C   1 ? 
ATOM   1215 O O   . ALA   A 1 153 ? 9.987   5.147   10.338  1.000 8.888  0 350  ALA   A O   1 ? 
ATOM   1216 C CB  . ALA   A 1 153 ? 8.539   5.473   7.158   1.000 8.865  0 350  ALA   A CB  1 ? 
ATOM   1217 N N   . ASP   A 1 154 ? 9.472   7.152   9.381   1.000 9.344  0 351  ASP   A N   1 ? 
ATOM   1218 C CA  . ASP   A 1 154 ? 9.380   7.985   10.612  1.000 9.933  0 351  ASP   A CA  1 ? 
ATOM   1219 C C   . ASP   A 1 154 ? 10.652  7.796   11.450  1.000 9.893  0 351  ASP   A C   1 ? 
ATOM   1220 O O   . ASP   A 1 154 ? 10.575  7.259   12.570  1.000 9.647  0 351  ASP   A O   1 ? 
ATOM   1221 C CB  . ASP   A 1 154 ? 8.078   7.702   11.371  1.000 10.807 0 351  ASP   A CB  1 ? 
ATOM   1222 C CG  . ASP   A 1 154 ? 6.911   8.590   10.959  1.000 11.893 0 351  ASP   A CG  1 ? 
ATOM   1223 O OD1 . ASP   A 1 154 ? 7.028   9.291   9.934   1.000 12.791 0 351  ASP   A OD1 1 ? 
ATOM   1224 O OD2 . ASP   A 1 154 ? 5.894   8.584   11.676  1.000 14.206 0 351  ASP   A OD2 1 ? 
ATOM   1225 N N   . LEU   A 1 155 ? 11.782  8.279   10.931  1.000 9.889  0 352  LEU   A N   1 ? 
ATOM   1226 C CA  . LEU   A 1 155 ? 13.124  8.130   11.559  1.000 10.070 0 352  LEU   A CA  1 ? 
ATOM   1227 C C   . LEU   A 1 155 ? 13.445  9.318   12.479  1.000 9.974  0 352  LEU   A C   1 ? 
ATOM   1228 O O   . LEU   A 1 155 ? 14.601  9.408   12.930  1.000 10.118 0 352  LEU   A O   1 ? 
ATOM   1229 C CB  . LEU   A 1 155 ? 14.179  8.020   10.454  1.000 10.232 0 352  LEU   A CB  1 ? 
ATOM   1230 C CG  . LEU   A 1 155 ? 13.939  6.967   9.375   1.000 10.557 0 352  LEU   A CG  1 ? 
ATOM   1231 C CD1 . LEU   A 1 155 ? 15.105  6.939   8.396   1.000 10.815 0 352  LEU   A CD1 1 ? 
ATOM   1232 C CD2 . LEU   A 1 155 ? 13.718  5.590   9.981   1.000 10.606 0 352  LEU   A CD2 1 ? 
ATOM   1233 N N   . GLY   A 1 156 ? 12.474  10.184  12.781  1.000 9.801  0 353  GLY   A N   1 ? 
ATOM   1234 C CA  . GLY   A 1 156 ? 12.699  11.459  13.487  1.000 9.983  0 353  GLY   A CA  1 ? 
ATOM   1235 C C   . GLY   A 1 156 ? 13.214  11.279  14.908  1.000 9.931  0 353  GLY   A C   1 ? 
ATOM   1236 O O   . GLY   A 1 156 ? 13.858  12.214  15.414  1.000 10.133 0 353  GLY   A O   1 ? 
ATOM   1237 N N   . LEU   A 1 157 ? 12.920  10.148  15.563  1.000 9.689  0 354  LEU   A N   1 ? 
ATOM   1238 C CA  . LEU   A 1 157 ? 13.328  9.901   16.974  1.000 9.767  0 354  LEU   A CA  1 ? 
ATOM   1239 C C   . LEU   A 1 157 ? 14.605  9.054   17.022  1.000 9.414  0 354  LEU   A C   1 ? 
ATOM   1240 O O   . LEU   A 1 157 ? 15.047  8.718   18.133  1.000 9.572  0 354  LEU   A O   1 ? 
ATOM   1241 C CB  . LEU   A 1 157 ? 12.176  9.226   17.725  1.000 10.086 0 354  LEU   A CB  1 ? 
ATOM   1242 C CG  . LEU   A 1 157 ? 10.936  10.097  17.941  1.000 10.453 0 354  LEU   A CG  1 ? 
ATOM   1243 C CD1 . LEU   A 1 157 ? 9.831   9.308   18.625  1.000 10.784 0 354  LEU   A CD1 1 ? 
ATOM   1244 C CD2 . LEU   A 1 157 ? 11.267  11.349  18.741  1.000 10.740 0 354  LEU   A CD2 1 ? 
ATOM   1245 N N   . ALA   A 1 158 ? 15.212  8.741   15.877  1.000 9.239  0 355  ALA   A N   1 ? 
ATOM   1246 C CA  . ALA   A 1 158 ? 16.390  7.849   15.807  1.000 9.196  0 355  ALA   A CA  1 ? 
ATOM   1247 C C   . ALA   A 1 158 ? 17.585  8.474   16.537  1.000 9.237  0 355  ALA   A C   1 ? 
ATOM   1248 O O   . ALA   A 1 158 ? 17.676  9.718   16.639  1.000 9.377  0 355  ALA   A O   1 ? 
ATOM   1249 C CB  . ALA   A 1 158 ? 16.725  7.542   14.373  1.000 9.127  0 355  ALA   A CB  1 ? 
ATOM   1250 N N   . VAL   A 1 159 ? 18.485  7.623   17.025  1.000 9.130  0 356  VAL   A N   1 ? 
ATOM   1251 C CA  . VAL   A 1 159 ? 19.785  8.039   17.624  1.000 9.468  0 356  VAL   A CA  1 ? 
ATOM   1252 C C   . VAL   A 1 159 ? 20.899  7.348   16.841  1.000 9.323  0 356  VAL   A C   1 ? 
ATOM   1253 O O   . VAL   A 1 159 ? 20.697  6.212   16.392  1.000 8.942  0 356  VAL   A O   1 ? 
ATOM   1254 C CB  . VAL   A 1 159 ? 19.858  7.729   19.130  1.000 9.825  0 356  VAL   A CB  1 ? 
ATOM   1255 C CG1 . VAL   A 1 159 ? 18.918  8.622   19.921  1.000 10.159 0 356  VAL   A CG1 1 ? 
ATOM   1256 C CG2 . VAL   A 1 159 ? 19.606  6.263   19.443  1.000 9.961  0 356  VAL   A CG2 1 ? 
ATOM   1257 N N   . ARG   A 1 160 ? 22.034  8.023   16.687  1.000 9.656  0 357  ARG   A N   1 ? 
ATOM   1258 C CA  . ARG   A 1 160 ? 23.182  7.503   15.906  1.000 10.200 0 357  ARG   A CA  1 ? 
ATOM   1259 C C   . ARG   A 1 160 ? 24.391  7.345   16.827  1.000 10.735 0 357  ARG   A C   1 ? 
ATOM   1260 O O   . ARG   A 1 160 ? 24.570  8.180   17.728  1.000 10.838 0 357  ARG   A O   1 ? 
ATOM   1261 C CB  . ARG   A 1 160 ? 23.478  8.430   14.729  1.000 10.033 0 357  ARG   A CB  1 ? 
ATOM   1262 C CG  . ARG   A 1 160 ? 22.270  8.649   13.832  1.000 10.127 0 357  ARG   A CG  1 ? 
ATOM   1263 C CD  . ARG   A 1 160 ? 22.620  9.395   12.565  1.000 10.241 0 357  ARG   A CD  1 ? 
ATOM   1264 N NE  . ARG   A 1 160 ? 23.085  10.737  12.870  1.000 10.350 0 357  ARG   A NE  1 ? 
ATOM   1265 C CZ  . ARG   A 1 160 ? 23.460  11.631  11.969  1.000 10.656 0 357  ARG   A CZ  1 ? 
ATOM   1266 N NH1 . ARG   A 1 160 ? 23.427  11.341  10.678  1.000 10.762 0 357  ARG   A NH1 1 ? 
ATOM   1267 N NH2 . ARG   A 1 160 ? 23.872  12.819  12.371  1.000 10.985 0 357  ARG   A NH2 1 ? 
ATOM   1268 N N   . HIS   A 1 161 ? 25.179  6.302   16.577  1.000 11.562 0 358  HIS   A N   1 ? 
ATOM   1269 C CA  . HIS   A 1 161 ? 26.312  5.843   17.421  1.000 12.896 0 358  HIS   A CA  1 ? 
ATOM   1270 C C   . HIS   A 1 161 ? 27.638  6.338   16.840  1.000 13.925 0 358  HIS   A C   1 ? 
ATOM   1271 O O   . HIS   A 1 161 ? 27.874  6.116   15.640  1.000 14.027 0 358  HIS   A O   1 ? 
ATOM   1272 C CB  . HIS   A 1 161 ? 26.273  4.313   17.478  1.000 13.319 0 358  HIS   A CB  1 ? 
ATOM   1273 C CG  . HIS   A 1 161 ? 27.235  3.695   18.431  1.000 14.120 0 358  HIS   A CG  1 ? 
ATOM   1274 N ND1 . HIS   A 1 161 ? 27.438  4.188   19.698  1.000 14.886 0 358  HIS   A ND1 1 ? 
ATOM   1275 C CD2 . HIS   A 1 161 ? 28.016  2.600   18.314  1.000 14.749 0 358  HIS   A CD2 1 ? 
ATOM   1276 C CE1 . HIS   A 1 161 ? 28.316  3.430   20.319  1.000 14.674 0 358  HIS   A CE1 1 ? 
ATOM   1277 N NE2 . HIS   A 1 161 ? 28.686  2.451   19.494  1.000 15.458 0 358  HIS   A NE2 1 ? 
ATOM   1278 N N   . ASP   A 1 162 ? 28.473  6.972   17.667  1.000 15.428 0 359  ASP   A N   1 ? 
ATOM   1279 C CA  . ASP   A 1 162 ? 29.914  7.193   17.377  1.000 17.213 0 359  ASP   A CA  1 ? 
ATOM   1280 C C   . ASP   A 1 162 ? 30.696  6.055   18.041  1.000 17.174 0 359  ASP   A C   1 ? 
ATOM   1281 O O   . ASP   A 1 162 ? 30.861  6.097   19.279  1.000 17.023 0 359  ASP   A O   1 ? 
ATOM   1282 C CB  . ASP   A 1 162 ? 30.395  8.564   17.854  1.000 18.749 0 359  ASP   A CB  1 ? 
ATOM   1283 C CG  . ASP   A 1 162 ? 31.826  8.857   17.440  1.000 20.164 0 359  ASP   A CG  1 ? 
ATOM   1284 O OD1 . ASP   A 1 162 ? 32.099  8.829   16.220  1.000 22.052 0 359  ASP   A OD1 1 ? 
ATOM   1285 O OD2 . ASP   A 1 162 ? 32.658  9.086   18.338  1.000 22.678 0 359  ASP   A OD2 1 ? 
ATOM   1286 N N   . SER   A 1 163 ? 31.130  5.071   17.251  1.000 18.098 0 360  SER   A N   1 ? 
ATOM   1287 C CA  . SER   A 1 163 ? 31.765  3.810   17.720  1.000 19.023 0 360  SER   A CA  1 ? 
ATOM   1288 C C   . SER   A 1 163 ? 33.143  4.088   18.334  1.000 19.504 0 360  SER   A C   1 ? 
ATOM   1289 O O   . SER   A 1 163 ? 33.567  3.303   19.201  1.000 19.577 0 360  SER   A O   1 ? 
ATOM   1290 C CB  . SER   A 1 163 ? 31.865  2.811   16.599  1.000 19.479 0 360  SER   A CB  1 ? 
ATOM   1291 O OG  . SER   A 1 163 ? 32.623  3.344   15.524  1.000 19.918 0 360  SER   A OG  1 ? 
ATOM   1292 N N   . ALA   A 1 164 ? 33.820  5.153   17.896  1.000 19.732 0 361  ALA   A N   1 ? 
ATOM   1293 C CA  . ALA   A 1 164 ? 35.168  5.539   18.377  1.000 20.218 0 361  ALA   A CA  1 ? 
ATOM   1294 C C   . ALA   A 1 164 ? 35.122  5.823   19.884  1.000 20.343 0 361  ALA   A C   1 ? 
ATOM   1295 O O   . ALA   A 1 164 ? 36.037  5.363   20.593  1.000 20.584 0 361  ALA   A O   1 ? 
ATOM   1296 C CB  . ALA   A 1 164 ? 35.675  6.727   17.597  1.000 20.507 0 361  ALA   A CB  1 ? 
ATOM   1297 N N   . THR   A 1 165 ? 34.086  6.527   20.357  1.000 20.143 0 362  THR   A N   1 ? 
ATOM   1298 C CA  . THR   A 1 165 ? 33.947  7.005   21.763  1.000 20.129 0 362  THR   A CA  1 ? 
ATOM   1299 C C   . THR   A 1 165 ? 32.818  6.273   22.505  1.000 19.876 0 362  THR   A C   1 ? 
ATOM   1300 O O   . THR   A 1 165 ? 32.709  6.475   23.730  1.000 19.938 0 362  THR   A O   1 ? 
ATOM   1301 C CB  . THR   A 1 165 ? 33.710  8.519   21.794  1.000 20.369 0 362  THR   A CB  1 ? 
ATOM   1302 O OG1 . THR   A 1 165 ? 32.588  8.804   20.958  1.000 20.931 0 362  THR   A OG1 1 ? 
ATOM   1303 C CG2 . THR   A 1 165 ? 34.915  9.306   21.327  1.000 20.566 0 362  THR   A CG2 1 ? 
ATOM   1304 N N   . ASP   A 1 166 ? 32.020  5.457   21.806  1.000 19.639 0 363  ASP   A N   1 ? 
ATOM   1305 C CA  . ASP   A 1 166 ? 30.810  4.780   22.349  1.000 19.226 0 363  ASP   A CA  1 ? 
ATOM   1306 C C   . ASP   A 1 166 ? 29.877  5.842   22.944  1.000 18.675 0 363  ASP   A C   1 ? 
ATOM   1307 O O   . ASP   A 1 166 ? 29.493  5.715   24.126  1.000 18.266 0 363  ASP   A O   1 ? 
ATOM   1308 C CB  . ASP   A 1 166 ? 31.168  3.693   23.370  1.000 19.511 0 363  ASP   A CB  1 ? 
ATOM   1309 C CG  . ASP   A 1 166 ? 30.007  2.795   23.772  1.000 20.128 0 363  ASP   A CG  1 ? 
ATOM   1310 O OD1 . ASP   A 1 166 ? 28.945  2.869   23.122  1.000 20.371 0 363  ASP   A OD1 1 ? 
ATOM   1311 O OD2 . ASP   A 1 166 ? 30.171  2.023   24.735  1.000 20.705 0 363  ASP   A OD2 1 ? 
ATOM   1312 N N   . THR   A 1 167 ? 29.541  6.857   22.147  1.000 18.220 0 364  THR   A N   1 ? 
ATOM   1313 C CA  . THR   A 1 167 ? 28.610  7.955   22.514  1.000 18.313 0 364  THR   A CA  1 ? 
ATOM   1314 C C   . THR   A 1 167 ? 27.482  8.023   21.483  1.000 17.813 0 364  THR   A C   1 ? 
ATOM   1315 O O   . THR   A 1 167 ? 27.596  7.382   20.419  1.000 17.683 0 364  THR   A O   1 ? 
ATOM   1316 C CB  . THR   A 1 167 ? 29.339  9.298   22.638  1.000 18.628 0 364  THR   A CB  1 ? 
ATOM   1317 O OG1 . THR   A 1 167 ? 29.936  9.609   21.380  1.000 19.385 0 364  THR   A OG1 1 ? 
ATOM   1318 C CG2 . THR   A 1 167 ? 30.396  9.291   23.720  1.000 18.857 0 364  THR   A CG2 1 ? 
ATOM   1319 N N   . ILE   A 1 168 ? 26.435  8.775   21.812  1.000 17.396 0 365  ILE   A N   1 ? 
ATOM   1320 C CA  . ILE   A 1 168 ? 25.219  8.966   20.971  1.000 17.142 0 365  ILE   A CA  1 ? 
ATOM   1321 C C   . ILE   A 1 168 ? 25.197  10.430  20.518  1.000 16.459 0 365  ILE   A C   1 ? 
ATOM   1322 O O   . ILE   A 1 168 ? 25.686  11.291  21.275  1.000 16.671 0 365  ILE   A O   1 ? 
ATOM   1323 C CB  . ILE   A 1 168 ? 23.965  8.539   21.757  1.000 17.901 0 365  ILE   A CB  1 ? 
ATOM   1324 C CG1 . ILE   A 1 168 ? 24.125  7.125   22.328  1.000 18.504 0 365  ILE   A CG1 1 ? 
ATOM   1325 C CG2 . ILE   A 1 168 ? 22.723  8.657   20.891  1.000 18.039 0 365  ILE   A CG2 1 ? 
ATOM   1326 C CD1 . ILE   A 1 168 ? 23.062  6.726   23.323  1.000 18.848 0 365  ILE   A CD1 1 ? 
ATOM   1327 N N   . ASP   A 1 169 ? 24.683  10.699  19.315  1.000 15.564 0 366  ASP   A N   1 ? 
ATOM   1328 C CA  . ASP   A 1 169 ? 24.864  12.003  18.619  1.000 15.523 0 366  ASP   A CA  1 ? 
ATOM   1329 C C   . ASP   A 1 169 ? 23.941  13.075  19.213  1.000 16.616 0 366  ASP   A C   1 ? 
ATOM   1330 O O   . ASP   A 1 169 ? 24.184  14.264  18.929  1.000 17.675 0 366  ASP   A O   1 ? 
ATOM   1331 C CB  . ASP   A 1 169 ? 24.685  11.872  17.104  1.000 14.339 0 366  ASP   A CB  1 ? 
ATOM   1332 C CG  . ASP   A 1 169 ? 23.287  11.513  16.631  1.000 13.678 0 366  ASP   A CG  1 ? 
ATOM   1333 O OD1 . ASP   A 1 169 ? 22.532  10.871  17.400  1.000 12.948 0 366  ASP   A OD1 1 ? 
ATOM   1334 O OD2 . ASP   A 1 169 ? 22.976  11.860  15.478  1.000 12.969 0 366  ASP   A OD2 1 ? 
ATOM   1335 N N   . ILE   A 1 170 ? 22.929  12.685  19.995  1.000 17.429 0 367  ILE   A N   1 ? 
ATOM   1336 C CA  . ILE   A 1 170 ? 22.031  13.624  20.733  1.000 18.762 0 367  ILE   A CA  1 ? 
ATOM   1337 C C   . ILE   A 1 170 ? 21.934  13.168  22.192  1.000 20.514 0 367  ILE   A C   1 ? 
ATOM   1338 O O   . ILE   A 1 170 ? 22.380  12.046  22.487  1.000 20.968 0 367  ILE   A O   1 ? 
ATOM   1339 C CB  . ILE   A 1 170 ? 20.644  13.716  20.061  1.000 18.630 0 367  ILE   A CB  1 ? 
ATOM   1340 C CG1 . ILE   A 1 170 ? 19.942  12.357  19.987  1.000 18.662 0 367  ILE   A CG1 1 ? 
ATOM   1341 C CG2 . ILE   A 1 170 ? 20.756  14.364  18.690  1.000 18.835 0 367  ILE   A CG2 1 ? 
ATOM   1342 C CD1 . ILE   A 1 170 ? 18.447  12.453  19.777  1.000 18.766 0 367  ILE   A CD1 1 ? 
ATOM   1343 N N   . ALA   A 1 171 ? 21.378  14.017  23.060  1.000 22.626 0 368  ALA   A N   1 ? 
ATOM   1344 C CA  . ALA   A 1 171 ? 21.067  13.708  24.475  1.000 24.832 0 368  ALA   A CA  1 ? 
ATOM   1345 C C   . ALA   A 1 171 ? 19.637  13.181  24.551  1.000 26.900 0 368  ALA   A C   1 ? 
ATOM   1346 O O   . ALA   A 1 171 ? 18.691  13.967  24.586  1.000 28.483 0 368  ALA   A O   1 ? 
ATOM   1347 N N   . PRO   A 1 172 ? 19.435  11.842  24.564  1.000 28.698 0 369  PRO   A N   1 ? 
ATOM   1348 C CA  . PRO   A 1 172 ? 18.098  11.256  24.451  1.000 29.193 0 369  PRO   A CA  1 ? 
ATOM   1349 C C   . PRO   A 1 172 ? 17.187  11.611  25.637  1.000 29.637 0 369  PRO   A C   1 ? 
ATOM   1350 O O   . PRO   A 1 172 ? 17.694  11.618  26.746  1.000 30.007 0 369  PRO   A O   1 ? 
ATOM   1351 C CB  . PRO   A 1 172 ? 18.361  9.740   24.406  1.000 29.209 0 369  PRO   A CB  1 ? 
ATOM   1352 C CG  . PRO   A 1 172 ? 19.825  9.615   24.036  1.000 29.108 0 369  PRO   A CG  1 ? 
ATOM   1353 C CD  . PRO   A 1 172 ? 20.480  10.814  24.686  1.000 28.812 0 369  PRO   A CD  1 ? 
ATOM   1354 N N   . ARG   A 1 175 ? 11.472  8.356   27.354  1.000 30.673 0 372  ARG   A N   1 ? 
ATOM   1355 C CA  . ARG   A 1 175 ? 10.153  7.777   26.970  1.000 30.502 0 372  ARG   A CA  1 ? 
ATOM   1356 C C   . ARG   A 1 175 ? 9.538   8.633   25.852  1.000 29.315 0 372  ARG   A C   1 ? 
ATOM   1357 O O   . ARG   A 1 175 ? 8.508   9.294   26.106  1.000 30.373 0 372  ARG   A O   1 ? 
ATOM   1358 C CB  . ARG   A 1 175 ? 9.227   7.697   28.191  1.000 31.216 0 372  ARG   A CB  1 ? 
ATOM   1359 C CG  . ARG   A 1 175 ? 9.554   6.581   29.176  1.000 31.860 0 372  ARG   A CG  1 ? 
ATOM   1360 C CD  . ARG   A 1 175 ? 8.813   6.795   30.484  1.000 32.479 0 372  ARG   A CD  1 ? 
ATOM   1361 N NE  . ARG   A 1 175 ? 9.156   5.854   31.545  1.000 33.034 0 372  ARG   A NE  1 ? 
ATOM   1362 C CZ  . ARG   A 1 175 ? 8.694   5.922   32.794  1.000 33.869 0 372  ARG   A CZ  1 ? 
ATOM   1363 N NH1 . ARG   A 1 175 ? 9.060   5.019   33.690  1.000 33.972 0 372  ARG   A NH1 1 ? 
ATOM   1364 N NH2 . ARG   A 1 175 ? 7.863   6.888   33.150  1.000 34.444 0 372  ARG   A NH2 1 ? 
ATOM   1365 N N   . VAL   A 1 176 ? 10.141  8.606   24.657  1.000 26.931 0 373  VAL   A N   1 ? 
ATOM   1366 C CA  . VAL   A 1 176 ? 9.829   9.530   23.521  1.000 25.187 0 373  VAL   A CA  1 ? 
ATOM   1367 C C   . VAL   A 1 176 ? 8.768   8.917   22.598  1.000 23.048 0 373  VAL   A C   1 ? 
ATOM   1368 O O   . VAL   A 1 176 ? 7.967   9.691   22.034  1.000 24.619 0 373  VAL   A O   1 ? 
ATOM   1369 C CB  . VAL   A 1 176 ? 11.093  9.901   22.717  1.000 25.488 0 373  VAL   A CB  1 ? 
ATOM   1370 C CG1 . VAL   A 1 176 ? 12.052  10.751  23.535  1.000 25.807 0 373  VAL   A CG1 1 ? 
ATOM   1371 C CG2 . VAL   A 1 176 ? 11.805  8.682   22.142  1.000 25.473 0 373  VAL   A CG2 1 ? 
ATOM   1372 N N   . GLY   A 1 177 ? 8.779   7.593   22.425  1.000 19.964 0 374  GLY   A N   1 ? 
ATOM   1373 C CA  . GLY   A 1 177 ? 8.029   6.899   21.361  1.000 17.471 0 374  GLY   A CA  1 ? 
ATOM   1374 C C   . GLY   A 1 177 ? 6.617   6.517   21.773  1.000 15.373 0 374  GLY   A C   1 ? 
ATOM   1375 O O   . GLY   A 1 177 ? 6.064   7.123   22.714  1.000 15.415 0 374  GLY   A O   1 ? 
ATOM   1376 N N   . THR   A 1 178 ? 6.050   5.543   21.063  1.000 13.111 0 375  THR   A N   1 ? 
ATOM   1377 C CA  . THR   A 1 178 ? 4.662   5.045   21.231  1.000 11.947 0 375  THR   A CA  1 ? 
ATOM   1378 C C   . THR   A 1 178 ? 4.605   4.139   22.466  1.000 11.292 0 375  THR   A C   1 ? 
ATOM   1379 O O   . THR   A 1 178 ? 5.342   3.138   22.508  1.000 10.501 0 375  THR   A O   1 ? 
ATOM   1380 C CB  . THR   A 1 178 ? 4.210   4.331   19.953  1.000 11.634 0 375  THR   A CB  1 ? 
ATOM   1381 O OG1 . THR   A 1 178 ? 4.437   5.238   18.870  1.000 11.649 0 375  THR   A OG1 1 ? 
ATOM   1382 C CG2 . THR   A 1 178 ? 2.763   3.895   20.001  1.000 11.486 0 375  THR   A CG2 1 ? 
ATOM   1383 N N   . LYS   A 1 179 ? 3.742   4.463   23.426  1.000 10.744 0 376  LYS   A N   1 ? 
ATOM   1384 C CA  . LYS   A 1 179 ? 3.746   3.821   24.768  1.000 10.982 0 376  LYS   A CA  1 ? 
ATOM   1385 C C   . LYS   A 1 179 ? 3.492   2.314   24.634  1.000 10.199 0 376  LYS   A C   1 ? 
ATOM   1386 O O   . LYS   A 1 179 ? 4.196   1.549   25.302  1.000 9.754  0 376  LYS   A O   1 ? 
ATOM   1387 C CB  . LYS   A 1 179 ? 2.751   4.532   25.688  1.000 11.960 0 376  LYS   A CB  1 ? 
ATOM   1388 C CG  . LYS   A 1 179 ? 3.168   5.951   26.049  1.000 13.052 0 376  LYS   A CG  1 ? 
ATOM   1389 C CD  . LYS   A 1 179 ? 2.063   6.810   26.608  1.000 13.937 0 376  LYS   A CD  1 ? 
ATOM   1390 C CE  . LYS   A 1 179 ? 2.522   8.227   26.883  1.000 14.609 0 376  LYS   A CE  1 ? 
ATOM   1391 N NZ  . LYS   A 1 179 ? 2.716   9.008   25.639  1.000 15.201 0 376  LYS   A NZ  1 ? 
ATOM   1392 N N   . ARG   A 1 180 ? 2.567   1.899   23.768  1.000 9.548  0 377  ARG   A N   1 ? 
ATOM   1393 C CA  . ARG   A 1 180 ? 2.194   0.469   23.601  1.000 9.296  0 377  ARG   A CA  1 ? 
ATOM   1394 C C   . ARG   A 1 180 ? 3.420   -0.383  23.239  1.000 9.041  0 377  ARG   A C   1 ? 
ATOM   1395 O O   . ARG   A 1 180 ? 3.473   -1.549  23.665  1.000 8.944  0 377  ARG   A O   1 ? 
ATOM   1396 C CB  . ARG   A 1 180 ? 1.113   0.340   22.527  1.000 9.269  0 377  ARG   A CB  1 ? 
ATOM   1397 C CG  . ARG   A 1 180 ? 0.604   -1.079  22.318  1.000 9.404  0 377  ARG   A CG  1 ? 
ATOM   1398 C CD  . ARG   A 1 180 ? -0.436  -1.136  21.218  1.000 9.382  0 377  ARG   A CD  1 ? 
ATOM   1399 N NE  . ARG   A 1 180 ? -1.611  -0.339  21.540  1.000 9.421  0 377  ARG   A NE  1 ? 
ATOM   1400 C CZ  . ARG   A 1 180 ? -2.649  -0.752  22.266  1.000 9.453  0 377  ARG   A CZ  1 ? 
ATOM   1401 N NH1 . ARG   A 1 180 ? -2.691  -1.980  22.758  1.000 9.384  0 377  ARG   A NH1 1 ? 
ATOM   1402 N NH2 . ARG   A 1 180 ? -3.656  0.073   22.495  1.000 9.653  0 377  ARG   A NH2 1 ? 
ATOM   1403 N N   . TYR   A 1 181 ? 4.368   0.158   22.471  1.000 8.908  0 378  TYR   A N   1 ? 
ATOM   1404 C CA  . TYR   A 1 181 ? 5.523   -0.607  21.935  1.000 8.912  0 378  TYR   A CA  1 ? 
ATOM   1405 C C   . TYR   A 1 181 ? 6.794   -0.349  22.752  1.000 9.134  0 378  TYR   A C   1 ? 
ATOM   1406 O O   . TYR   A 1 181 ? 7.855   -0.866  22.365  1.000 9.214  0 378  TYR   A O   1 ? 
ATOM   1407 C CB  . TYR   A 1 181 ? 5.769   -0.244  20.471  1.000 8.650  0 378  TYR   A CB  1 ? 
ATOM   1408 C CG  . TYR   A 1 181 ? 4.715   -0.721  19.506  1.000 8.505  0 378  TYR   A CG  1 ? 
ATOM   1409 C CD1 . TYR   A 1 181 ? 3.531   -0.020  19.335  1.000 8.484  0 378  TYR   A CD1 1 ? 
ATOM   1410 C CD2 . TYR   A 1 181 ? 4.910   -1.859  18.741  1.000 8.452  0 378  TYR   A CD2 1 ? 
ATOM   1411 C CE1 . TYR   A 1 181 ? 2.564   -0.442  18.437  1.000 8.468  0 378  TYR   A CE1 1 ? 
ATOM   1412 C CE2 . TYR   A 1 181 ? 3.954   -2.295  17.838  1.000 8.486  0 378  TYR   A CE2 1 ? 
ATOM   1413 C CZ  . TYR   A 1 181 ? 2.778   -1.583  17.684  1.000 8.462  0 378  TYR   A CZ  1 ? 
ATOM   1414 O OH  . TYR   A 1 181 ? 1.835   -1.988  16.783  1.000 8.776  0 378  TYR   A OH  1 ? 
ATOM   1415 N N   . MET   A 1 182 ? 6.715   0.424   23.838  1.000 9.540  0 379  MET   A N   1 ? 
ATOM   1416 C CA  . MET   A 1 182 ? 7.919   0.756   24.643  1.000 10.106 0 379  MET   A CA  1 ? 
ATOM   1417 C C   . MET   A 1 182 ? 8.461   -0.519  25.288  1.000 10.142 0 379  MET   A C   1 ? 
ATOM   1418 O O   . MET   A 1 182 ? 7.670   -1.303  25.841  1.000 9.972  0 379  MET   A O   1 ? 
ATOM   1419 C CB  . MET   A 1 182 ? 7.617   1.779   25.738  1.000 10.643 0 379  MET   A CB  1 ? 
ATOM   1420 C CG  . MET   A 1 182 ? 7.534   3.190   25.228  1.000 11.237 0 379  MET   A CG  1 ? 
ATOM   1421 S SD  . MET   A 1 182 ? 7.046   4.306   26.551  1.000 12.213 0 379  MET   A SD  1 ? 
ATOM   1422 C CE  . MET   A 1 182 ? 7.063   5.874   25.685  1.000 12.534 0 379  MET   A CE  1 ? 
ATOM   1423 N N   . ALA   A 1 183 ? 9.778   -0.707  25.219  1.000 10.448 0 380  ALA   A N   1 ? 
ATOM   1424 C CA  . ALA   A 1 183 ? 10.486  -1.851  25.825  1.000 10.841 0 380  ALA   A CA  1 ? 
ATOM   1425 C C   . ALA   A 1 183 ? 10.308  -1.801  27.339  1.000 10.815 0 380  ALA   A C   1 ? 
ATOM   1426 O O   . ALA   A 1 183 ? 10.141  -0.731  27.921  1.000 10.370 0 380  ALA   A O   1 ? 
ATOM   1427 C CB  . ALA   A 1 183 ? 11.940  -1.821  25.428  1.000 10.960 0 380  ALA   A CB  1 ? 
ATOM   1428 N N   . PRO   A 1 184 ? 10.319  -2.968  28.016  1.000 11.257 0 381  PRO   A N   1 ? 
ATOM   1429 C CA  . PRO   A 1 184 ? 10.200  -3.024  29.473  1.000 11.531 0 381  PRO   A CA  1 ? 
ATOM   1430 C C   . PRO   A 1 184 ? 11.119  -2.021  30.195  1.000 11.499 0 381  PRO   A C   1 ? 
ATOM   1431 O O   . PRO   A 1 184 ? 10.667  -1.334  31.091  1.000 11.505 0 381  PRO   A O   1 ? 
ATOM   1432 C CB  . PRO   A 1 184 ? 10.603  -4.475  29.787  1.000 11.744 0 381  PRO   A CB  1 ? 
ATOM   1433 C CG  . PRO   A 1 184 ? 10.212  -5.250  28.550  1.000 11.791 0 381  PRO   A CG  1 ? 
ATOM   1434 C CD  . PRO   A 1 184 ? 10.435  -4.298  27.398  1.000 11.644 0 381  PRO   A CD  1 ? 
ATOM   1435 N N   . GLU   A 1 185 ? 12.383  -1.944  29.768  1.000 11.603 0 382  GLU   A N   1 ? 
ATOM   1436 C CA  . GLU   A 1 185 ? 13.431  -1.086  30.388  1.000 11.703 0 382  GLU   A CA  1 ? 
ATOM   1437 C C   . GLU   A 1 185 ? 13.153  0.400   30.113  1.000 11.780 0 382  GLU   A C   1 ? 
ATOM   1438 O O   . GLU   A 1 185 ? 13.680  1.245   30.854  1.000 11.737 0 382  GLU   A O   1 ? 
ATOM   1439 C CB  . GLU   A 1 185 ? 14.826  -1.500  29.906  1.000 11.822 0 382  GLU   A CB  1 ? 
ATOM   1440 C CG  . GLU   A 1 185 ? 15.052  -1.365  28.406  1.000 11.940 0 382  GLU   A CG  1 ? 
ATOM   1441 C CD  . GLU   A 1 185 ? 14.646  -2.552  27.545  1.000 12.185 0 382  GLU   A CD  1 ? 
ATOM   1442 O OE1 . GLU   A 1 185 ? 13.797  -3.358  27.987  1.000 12.648 0 382  GLU   A OE1 1 ? 
ATOM   1443 O OE2 . GLU   A 1 185 ? 15.177  -2.669  26.425  1.000 12.422 0 382  GLU   A OE2 1 ? 
ATOM   1444 N N   . VAL   A 1 186 ? 12.370  0.719   29.080  1.000 11.696 0 383  VAL   A N   1 ? 
ATOM   1445 C CA  . VAL   A 1 186 ? 11.919  2.114   28.797  1.000 12.035 0 383  VAL   A CA  1 ? 
ATOM   1446 C C   . VAL   A 1 186 ? 10.731  2.433   29.716  1.000 12.188 0 383  VAL   A C   1 ? 
ATOM   1447 O O   . VAL   A 1 186 ? 10.716  3.528   30.305  1.000 12.368 0 383  VAL   A O   1 ? 
ATOM   1448 C CB  . VAL   A 1 186 ? 11.586  2.302   27.305  1.000 12.114 0 383  VAL   A CB  1 ? 
ATOM   1449 C CG1 . VAL   A 1 186 ? 10.938  3.652   27.030  1.000 12.216 0 383  VAL   A CG1 1 ? 
ATOM   1450 C CG2 . VAL   A 1 186 ? 12.825  2.119   26.443  1.000 12.079 0 383  VAL   A CG2 1 ? 
ATOM   1451 N N   . LEU   A 1 187 ? 9.790   1.496   29.864  1.000 12.467 0 384  LEU   A N   1 ? 
ATOM   1452 C CA  . LEU   A 1 187 ? 8.568   1.666   30.697  1.000 12.894 0 384  LEU   A CA  1 ? 
ATOM   1453 C C   . LEU   A 1 187 ? 8.936   1.898   32.168  1.000 13.838 0 384  LEU   A C   1 ? 
ATOM   1454 O O   . LEU   A 1 187 ? 8.261   2.723   32.808  1.000 14.629 0 384  LEU   A O   1 ? 
ATOM   1455 C CB  . LEU   A 1 187 ? 7.679   0.427   30.558  1.000 12.425 0 384  LEU   A CB  1 ? 
ATOM   1456 C CG  . LEU   A 1 187 ? 6.957   0.280   29.221  1.000 12.222 0 384  LEU   A CG  1 ? 
ATOM   1457 C CD1 . LEU   A 1 187 ? 6.235   -1.054  29.156  1.000 12.072 0 384  LEU   A CD1 1 ? 
ATOM   1458 C CD2 . LEU   A 1 187 ? 5.986   1.430   28.991  1.000 12.092 0 384  LEU   A CD2 1 ? 
ATOM   1459 N N   . ASP   A 1 188 ? 9.937   1.186   32.696  1.000 14.835 0 385  ASP   A N   1 ? 
ATOM   1460 C CA  . ASP   A 1 188 ? 10.337  1.305   34.126  1.000 15.862 0 385  ASP   A CA  1 ? 
ATOM   1461 C C   . ASP   A 1 188 ? 11.526  2.271   34.259  1.000 16.580 0 385  ASP   A C   1 ? 
ATOM   1462 O O   . ASP   A 1 188 ? 11.999  2.459   35.397  1.000 16.388 0 385  ASP   A O   1 ? 
ATOM   1463 C CB  . ASP   A 1 188 ? 10.585  -0.069  34.755  1.000 16.495 0 385  ASP   A CB  1 ? 
ATOM   1464 C CG  . ASP   A 1 188 ? 11.863  -0.763  34.322  1.000 16.770 0 385  ASP   A CG  1 ? 
ATOM   1465 O OD1 . ASP   A 1 188 ? 12.661  -0.137  33.596  1.000 16.714 0 385  ASP   A OD1 1 ? 
ATOM   1466 O OD2 . ASP   A 1 188 ? 12.051  -1.928  34.727  1.000 18.416 0 385  ASP   A OD2 1 ? 
ATOM   1467 N N   . ASP   A 1 189 ? 11.992  2.847   33.144  1.000 17.344 0 386  ASP   A N   1 ? 
ATOM   1468 C CA  . ASP   A 1 189 ? 13.012  3.932   33.082  1.000 18.577 0 386  ASP   A CA  1 ? 
ATOM   1469 C C   . ASP   A 1 189 ? 14.366  3.437   33.609  1.000 18.234 0 386  ASP   A C   1 ? 
ATOM   1470 O O   . ASP   A 1 189 ? 15.174  4.290   34.039  1.000 18.705 0 386  ASP   A O   1 ? 
ATOM   1471 C CB  . ASP   A 1 189 ? 12.550  5.171   33.856  1.000 19.815 0 386  ASP   A CB  1 ? 
ATOM   1472 C CG  . ASP   A 1 189 ? 13.252  6.460   33.460  1.000 21.047 0 386  ASP   A CG  1 ? 
ATOM   1473 O OD1 . ASP   A 1 189 ? 13.809  6.513   32.342  1.000 21.968 0 386  ASP   A OD1 1 ? 
ATOM   1474 O OD2 . ASP   A 1 189 ? 13.237  7.405   34.274  1.000 23.378 0 386  ASP   A OD2 1 ? 
ATOM   1475 N N   . SER   A 1 190 ? 14.626  2.127   33.550  1.000 17.541 0 387  SER   A N   1 ? 
ATOM   1476 C CA  . SER   A 1 190 ? 15.892  1.500   34.013  1.000 17.834 0 387  SER   A CA  1 ? 
ATOM   1477 C C   . SER   A 1 190 ? 16.928  1.494   32.882  1.000 17.619 0 387  SER   A C   1 ? 
ATOM   1478 O O   . SER   A 1 190 ? 18.105  1.223   33.173  1.000 18.026 0 387  SER   A O   1 ? 
ATOM   1479 C CB  . SER   A 1 190 ? 15.656  0.112   34.539  1.000 18.033 0 387  SER   A CB  1 ? 
ATOM   1480 O OG  . SER   A 1 190 ? 15.246  -0.761  33.500  1.000 18.037 0 387  SER   A OG  1 ? 
ATOM   1481 N N   . ILE   A 1 191 ? 16.509  1.776   31.644  1.000 17.282 0 388  ILE   A N   1 ? 
ATOM   1482 C CA  . ILE   A 1 191 ? 17.410  1.787   30.454  1.000 17.117 0 388  ILE   A CA  1 ? 
ATOM   1483 C C   . ILE   A 1 191 ? 18.543  2.793   30.695  1.000 17.872 0 388  ILE   A C   1 ? 
ATOM   1484 O O   . ILE   A 1 191 ? 18.265  3.906   31.189  1.000 17.531 0 388  ILE   A O   1 ? 
ATOM   1485 C CB  . ILE   A 1 191 ? 16.638  2.077   29.148  1.000 16.558 0 388  ILE   A CB  1 ? 
ATOM   1486 C CG1 . ILE   A 1 191 ? 17.550  1.917   27.929  1.000 16.285 0 388  ILE   A CG1 1 ? 
ATOM   1487 C CG2 . ILE   A 1 191 ? 15.970  3.446   29.177  1.000 16.372 0 388  ILE   A CG2 1 ? 
ATOM   1488 C CD1 . ILE   A 1 191 ? 16.820  1.886   26.607  1.000 16.017 0 388  ILE   A CD1 1 ? 
ATOM   1489 N N   . ASN   A 1 192 ? 19.776  2.390   30.375  1.000 18.839 0 389  ASN   A N   1 ? 
ATOM   1490 C CA  . ASN   A 1 192 ? 20.976  3.265   30.374  1.000 20.384 0 389  ASN   A CA  1 ? 
ATOM   1491 C C   . ASN   A 1 192 ? 20.977  4.058   29.062  1.000 21.435 0 389  ASN   A C   1 ? 
ATOM   1492 O O   . ASN   A 1 192 ? 21.328  3.477   28.019  1.000 21.485 0 389  ASN   A O   1 ? 
ATOM   1493 C CB  . ASN   A 1 192 ? 22.256  2.447   30.565  1.000 20.537 0 389  ASN   A CB  1 ? 
ATOM   1494 C CG  . ASN   A 1 192 ? 23.499  3.300   30.699  1.000 20.879 0 389  ASN   A CG  1 ? 
ATOM   1495 O OD1 . ASN   A 1 192 ? 23.455  4.513   30.502  1.000 21.128 0 389  ASN   A OD1 1 ? 
ATOM   1496 N ND2 . ASN   A 1 192 ? 24.612  2.672   31.037  1.000 21.605 0 389  ASN   A ND2 1 ? 
ATOM   1497 N N   . MET   A 1 193 ? 20.598  5.338   29.119  1.000 23.092 0 390  MET   A N   1 ? 
ATOM   1498 C CA  . MET   A 1 193 ? 20.383  6.194   27.920  1.000 24.729 0 390  MET   A CA  1 ? 
ATOM   1499 C C   . MET   A 1 193 ? 21.717  6.737   27.391  1.000 24.470 0 390  MET   A C   1 ? 
ATOM   1500 O O   . MET   A 1 193 ? 21.687  7.461   26.375  1.000 25.155 0 390  MET   A O   1 ? 
ATOM   1501 C CB  . MET   A 1 193 ? 19.438  7.354   28.244  1.000 26.651 0 390  MET   A CB  1 ? 
ATOM   1502 C CG  . MET   A 1 193 ? 18.042  6.889   28.605  1.000 28.143 0 390  MET   A CG  1 ? 
ATOM   1503 S SD  . MET   A 1 193 ? 16.768  7.938   27.878  1.000 31.282 0 390  MET   A SD  1 ? 
ATOM   1504 C CE  . MET   A 1 193 ? 16.908  9.386   28.923  1.000 30.890 0 390  MET   A CE  1 ? 
ATOM   1505 N N   . LYS   A 1 194 ? 22.835  6.398   28.042  1.000 23.790 0 391  LYS   A N   1 ? 
ATOM   1506 C CA  . LYS   A 1 194 ? 24.215  6.681   27.559  1.000 23.186 0 391  LYS   A CA  1 ? 
ATOM   1507 C C   . LYS   A 1 194 ? 24.742  5.485   26.753  1.000 22.735 0 391  LYS   A C   1 ? 
ATOM   1508 O O   . LYS   A 1 194 ? 25.798  5.635   26.109  1.000 23.449 0 391  LYS   A O   1 ? 
ATOM   1509 C CB  . LYS   A 1 194 ? 25.138  6.982   28.745  1.000 23.383 0 391  LYS   A CB  1 ? 
ATOM   1510 N N   . HIS   A 1 195 ? 24.030  4.352   26.779  1.000 21.494 0 392  HIS   A N   1 ? 
ATOM   1511 C CA  . HIS   A 1 195 ? 24.453  3.049   26.198  1.000 20.453 0 392  HIS   A CA  1 ? 
ATOM   1512 C C   . HIS   A 1 195 ? 23.683  2.789   24.896  1.000 18.554 0 392  HIS   A C   1 ? 
ATOM   1513 O O   . HIS   A 1 195 ? 22.503  2.405   24.974  1.000 18.412 0 392  HIS   A O   1 ? 
ATOM   1514 C CB  . HIS   A 1 195 ? 24.244  1.941   27.240  1.000 21.259 0 392  HIS   A CB  1 ? 
ATOM   1515 C CG  . HIS   A 1 195 ? 24.854  0.631   26.879  1.000 22.136 0 392  HIS   A CG  1 ? 
ATOM   1516 N ND1 . HIS   A 1 195 ? 24.149  -0.554  26.953  1.000 22.554 0 392  HIS   A ND1 1 ? 
ATOM   1517 C CD2 . HIS   A 1 195 ? 26.093  0.309   26.450  1.000 22.581 0 392  HIS   A CD2 1 ? 
ATOM   1518 C CE1 . HIS   A 1 195 ? 24.929  -1.551  26.588  1.000 22.814 0 392  HIS   A CE1 1 ? 
ATOM   1519 N NE2 . HIS   A 1 195 ? 26.127  -1.047  26.271  1.000 23.102 0 392  HIS   A NE2 1 ? 
ATOM   1520 N N   . PHE   A 1 196 ? 24.321  2.984   23.739  1.000 16.667 0 393  PHE   A N   1 ? 
ATOM   1521 C CA  . PHE   A 1 196 ? 23.666  2.860   22.408  1.000 15.351 0 393  PHE   A CA  1 ? 
ATOM   1522 C C   . PHE   A 1 196 ? 23.081  1.450   22.231  1.000 14.946 0 393  PHE   A C   1 ? 
ATOM   1523 O O   . PHE   A 1 196 ? 21.955  1.331   21.713  1.000 13.749 0 393  PHE   A O   1 ? 
ATOM   1524 C CB  . PHE   A 1 196 ? 24.637  3.196   21.274  1.000 14.663 0 393  PHE   A CB  1 ? 
ATOM   1525 C CG  . PHE   A 1 196 ? 24.040  2.980   19.907  1.000 14.109 0 393  PHE   A CG  1 ? 
ATOM   1526 C CD1 . PHE   A 1 196 ? 23.166  3.906   19.353  1.000 14.348 0 393  PHE   A CD1 1 ? 
ATOM   1527 C CD2 . PHE   A 1 196 ? 24.309  1.820   19.197  1.000 14.085 0 393  PHE   A CD2 1 ? 
ATOM   1528 C CE1 . PHE   A 1 196 ? 22.604  3.686   18.105  1.000 14.058 0 393  PHE   A CE1 1 ? 
ATOM   1529 C CE2 . PHE   A 1 196 ? 23.744  1.603   17.952  1.000 14.314 0 393  PHE   A CE2 1 ? 
ATOM   1530 C CZ  . PHE   A 1 196 ? 22.891  2.535   17.410  1.000 13.971 0 393  PHE   A CZ  1 ? 
ATOM   1531 N N   . GLU   A 1 197 ? 23.816  0.412   22.640  1.000 15.077 0 394  GLU   A N   1 ? 
ATOM   1532 C CA  . GLU   A 1 197 ? 23.410  -1.011  22.478  1.000 15.525 0 394  GLU   A CA  1 ? 
ATOM   1533 C C   . GLU   A 1 197 ? 22.034  -1.237  23.120  1.000 14.465 0 394  GLU   A C   1 ? 
ATOM   1534 O O   . GLU   A 1 197 ? 21.271  -2.070  22.600  1.000 13.827 0 394  GLU   A O   1 ? 
ATOM   1535 C CB  . GLU   A 1 197 ? 24.462  -1.944  23.082  1.000 17.233 0 394  GLU   A CB  1 ? 
ATOM   1536 C CG  . GLU   A 1 197 ? 24.270  -3.406  22.717  1.000 19.095 0 394  GLU   A CG  1 ? 
ATOM   1537 C CD  . GLU   A 1 197 ? 24.482  -3.751  21.253  1.000 20.766 0 394  GLU   A CD  1 ? 
ATOM   1538 O OE1 . GLU   A 1 197 ? 25.183  -2.989  20.558  1.000 22.610 0 394  GLU   A OE1 1 ? 
ATOM   1539 O OE2 . GLU   A 1 197 ? 23.942  -4.786  20.813  1.000 23.826 0 394  GLU   A OE2 1 ? 
ATOM   1540 N N   . SER   A 1 198 ? 21.714  -0.518  24.199  1.000 13.776 0 395  SER   A N   1 ? 
ATOM   1541 C CA  . SER   A 1 198 ? 20.408  -0.624  24.902  1.000 13.584 0 395  SER   A CA  1 ? 
ATOM   1542 C C   . SER   A 1 198 ? 19.272  -0.149  23.984  1.000 12.920 0 395  SER   A C   1 ? 
ATOM   1543 O O   . SER   A 1 198 ? 18.198  -0.763  24.019  1.000 12.373 0 395  SER   A O   1 ? 
ATOM   1544 C CB  . SER   A 1 198 ? 20.424  0.115   26.212  1.000 13.932 0 395  SER   A CB  1 ? 
ATOM   1545 O OG  . SER   A 1 198 ? 21.264  -0.547  27.150  1.000 14.823 0 395  SER   A OG  1 ? 
ATOM   1546 N N   . PHE   A 1 199 ? 19.491  0.893   23.178  1.000 12.636 0 396  PHE   A N   1 ? 
ATOM   1547 C CA  . PHE   A 1 199 ? 18.481  1.392   22.207  1.000 12.625 0 396  PHE   A CA  1 ? 
ATOM   1548 C C   . PHE   A 1 199 ? 18.260  0.351   21.100  1.000 12.002 0 396  PHE   A C   1 ? 
ATOM   1549 O O   . PHE   A 1 199 ? 17.102  0.144   20.719  1.000 11.155 0 396  PHE   A O   1 ? 
ATOM   1550 C CB  . PHE   A 1 199 ? 18.874  2.762   21.650  1.000 13.518 0 396  PHE   A CB  1 ? 
ATOM   1551 C CG  . PHE   A 1 199 ? 18.779  3.877   22.659  1.000 14.423 0 396  PHE   A CG  1 ? 
ATOM   1552 C CD1 . PHE   A 1 199 ? 17.546  4.297   23.135  1.000 15.039 0 396  PHE   A CD1 1 ? 
ATOM   1553 C CD2 . PHE   A 1 199 ? 19.919  4.494   23.149  1.000 15.332 0 396  PHE   A CD2 1 ? 
ATOM   1554 C CE1 . PHE   A 1 199 ? 17.456  5.314   24.074  1.000 15.702 0 396  PHE   A CE1 1 ? 
ATOM   1555 C CE2 . PHE   A 1 199 ? 19.826  5.516   24.081  1.000 15.697 0 396  PHE   A CE2 1 ? 
ATOM   1556 C CZ  . PHE   A 1 199 ? 18.596  5.922   24.542  1.000 15.771 0 396  PHE   A CZ  1 ? 
ATOM   1557 N N   . LYS   A 1 200 ? 19.317  -0.298  20.606  1.000 11.594 0 397  LYS   A N   1 ? 
ATOM   1558 C CA  . LYS   A 1 200 ? 19.189  -1.385  19.594  1.000 12.057 0 397  LYS   A CA  1 ? 
ATOM   1559 C C   . LYS   A 1 200 ? 18.292  -2.493  20.155  1.000 11.590 0 397  LYS   A C   1 ? 
ATOM   1560 O O   . LYS   A 1 200 ? 17.375  -2.946  19.448  1.000 11.110 0 397  LYS   A O   1 ? 
ATOM   1561 C CB  . LYS   A 1 200 ? 20.551  -1.980  19.223  1.000 12.786 0 397  LYS   A CB  1 ? 
ATOM   1562 C CG  . LYS   A 1 200 ? 21.371  -1.179  18.222  1.000 13.647 0 397  LYS   A CG  1 ? 
ATOM   1563 C CD  . LYS   A 1 200 ? 22.761  -1.748  17.979  1.000 14.410 0 397  LYS   A CD  1 ? 
ATOM   1564 C CE  . LYS   A 1 200 ? 22.788  -3.216  17.604  1.000 15.126 0 397  LYS   A CE  1 ? 
ATOM   1565 N NZ  . LYS   A 1 200 ? 24.176  -3.734  17.542  1.000 15.663 0 397  LYS   A NZ  1 ? 
ATOM   1566 N N   . ARG   A 1 201 ? 18.559  -2.919  21.389  1.000 11.463 0 398  ARG   A N   1 ? 
ATOM   1567 C CA  . ARG   A 1 201 ? 17.829  -4.032  22.050  1.000 11.652 0 398  ARG   A CA  1 ? 
ATOM   1568 C C   . ARG   A 1 201 ? 16.351  -3.656  22.223  1.000 10.854 0 398  ARG   A C   1 ? 
ATOM   1569 O O   . ARG   A 1 201 ? 15.499  -4.544  22.072  1.000 10.904 0 398  ARG   A O   1 ? 
ATOM   1570 C CB  . ARG   A 1 201 ? 18.508  -4.377  23.377  1.000 12.667 0 398  ARG   A CB  1 ? 
ATOM   1571 C CG  . ARG   A 1 201 ? 19.875  -5.021  23.205  1.000 13.619 0 398  ARG   A CG  1 ? 
ATOM   1572 C CD  . ARG   A 1 201 ? 20.772  -4.845  24.413  1.000 14.786 0 398  ARG   A CD  1 ? 
ATOM   1573 N NE  . ARG   A 1 201 ? 22.017  -5.585  24.276  1.000 15.871 0 398  ARG   A NE  1 ? 
ATOM   1574 C CZ  . ARG   A 1 201 ? 23.014  -5.560  25.158  1.000 16.711 0 398  ARG   A CZ  1 ? 
ATOM   1575 N NH1 . ARG   A 1 201 ? 22.918  -4.824  26.253  1.000 17.129 0 398  ARG   A NH1 1 ? 
ATOM   1576 N NH2 . ARG   A 1 201 ? 24.105  -6.273  24.937  1.000 17.643 0 398  ARG   A NH2 1 ? 
ATOM   1577 N N   . ALA   A 1 202 ? 16.047  -2.394  22.527  1.000 10.063 0 399  ALA   A N   1 ? 
ATOM   1578 C CA  . ALA   A 1 202 ? 14.655  -1.905  22.666  1.000 9.602  0 399  ALA   A CA  1 ? 
ATOM   1579 C C   . ALA   A 1 202 ? 13.931  -2.018  21.315  1.000 9.064  0 399  ALA   A C   1 ? 
ATOM   1580 O O   . ALA   A 1 202 ? 12.755  -2.415  21.309  1.000 9.062  0 399  ALA   A O   1 ? 
ATOM   1581 C CB  . ALA   A 1 202 ? 14.639  -0.498  23.205  1.000 9.698  0 399  ALA   A CB  1 ? 
ATOM   1582 N N   . ASP   A 1 203 ? 14.606  -1.707  20.202  1.000 8.560  0 400  ASP   A N   1 ? 
ATOM   1583 C CA  . ASP   A 1 203 ? 14.027  -1.857  18.839  1.000 8.382  0 400  ASP   A CA  1 ? 
ATOM   1584 C C   . ASP   A 1 203 ? 13.614  -3.317  18.606  1.000 8.235  0 400  ASP   A C   1 ? 
ATOM   1585 O O   . ASP   A 1 203 ? 12.568  -3.540  17.980  1.000 8.023  0 400  ASP   A O   1 ? 
ATOM   1586 C CB  . ASP   A 1 203 ? 15.000  -1.439  17.733  1.000 8.307  0 400  ASP   A CB  1 ? 
ATOM   1587 C CG  . ASP   A 1 203 ? 15.197  0.055   17.526  1.000 8.340  0 400  ASP   A CG  1 ? 
ATOM   1588 O OD1 . ASP   A 1 203 ? 14.410  0.857   18.070  1.000 8.497  0 400  ASP   A OD1 1 ? 
ATOM   1589 O OD2 . ASP   A 1 203 ? 16.142  0.400   16.789  1.000 8.324  0 400  ASP   A OD2 1 ? 
ATOM   1590 N N   . ILE   A 1 204 ? 14.420  -4.281  19.057  1.000 8.052  0 401  ILE   A N   1 ? 
ATOM   1591 C CA  . ILE   A 1 204 ? 14.165  -5.732  18.819  1.000 8.165  0 401  ILE   A CA  1 ? 
ATOM   1592 C C   . ILE   A 1 204 ? 12.861  -6.131  19.520  1.000 7.743  0 401  ILE   A C   1 ? 
ATOM   1593 O O   . ILE   A 1 204 ? 12.070  -6.871  18.917  1.000 7.847  0 401  ILE   A O   1 ? 
ATOM   1594 C CB  . ILE   A 1 204 ? 15.363  -6.585  19.282  1.000 8.375  0 401  ILE   A CB  1 ? 
ATOM   1595 C CG1 . ILE   A 1 204 ? 16.623  -6.288  18.460  1.000 8.811  0 401  ILE   A CG1 1 ? 
ATOM   1596 C CG2 . ILE   A 1 204 ? 15.011  -8.068  19.278  1.000 8.499  0 401  ILE   A CG2 1 ? 
ATOM   1597 C CD1 . ILE   A 1 204 ? 16.485  -6.560  16.982  1.000 9.072  0 401  ILE   A CD1 1 ? 
ATOM   1598 N N   . TYR   A 1 205 ? 12.640  -5.662  20.747  1.000 7.657  0 402  TYR   A N   1 ? 
ATOM   1599 C CA  . TYR   A 1 205 ? 11.386  -5.928  21.498  1.000 7.622  0 402  TYR   A CA  1 ? 
ATOM   1600 C C   . TYR   A 1 205 ? 10.189  -5.462  20.659  1.000 7.588  0 402  TYR   A C   1 ? 
ATOM   1601 O O   . TYR   A 1 205 ? 9.232   -6.232  20.481  1.000 7.482  0 402  TYR   A O   1 ? 
ATOM   1602 C CB  . TYR   A 1 205 ? 11.418  -5.265  22.874  1.000 7.575  0 402  TYR   A CB  1 ? 
ATOM   1603 C CG  . TYR   A 1 205 ? 10.071  -5.205  23.548  1.000 7.601  0 402  TYR   A CG  1 ? 
ATOM   1604 C CD1 . TYR   A 1 205 ? 9.619   -6.250  24.338  1.000 7.662  0 402  TYR   A CD1 1 ? 
ATOM   1605 C CD2 . TYR   A 1 205 ? 9.230   -4.120  23.367  1.000 7.563  0 402  TYR   A CD2 1 ? 
ATOM   1606 C CE1 . TYR   A 1 205 ? 8.376   -6.210  24.949  1.000 7.782  0 402  TYR   A CE1 1 ? 
ATOM   1607 C CE2 . TYR   A 1 205 ? 7.986   -4.061  23.972  1.000 7.616  0 402  TYR   A CE2 1 ? 
ATOM   1608 C CZ  . TYR   A 1 205 ? 7.554   -5.113  24.760  1.000 7.733  0 402  TYR   A CZ  1 ? 
ATOM   1609 O OH  . TYR   A 1 205 ? 6.331   -5.061  25.364  1.000 7.833  0 402  TYR   A OH  1 ? 
ATOM   1610 N N   . ALA   A 1 206 ? 10.244  -4.229  20.149  1.000 7.588  0 403  ALA   A N   1 ? 
ATOM   1611 C CA  . ALA   A 1 206 ? 9.159   -3.637  19.333  1.000 7.740  0 403  ALA   A CA  1 ? 
ATOM   1612 C C   . ALA   A 1 206 ? 8.970   -4.462  18.057  1.000 7.793  0 403  ALA   A C   1 ? 
ATOM   1613 O O   . ALA   A 1 206 ? 7.814   -4.719  17.678  1.000 7.753  0 403  ALA   A O   1 ? 
ATOM   1614 C CB  . ALA   A 1 206 ? 9.457   -2.195  19.027  1.000 7.810  0 403  ALA   A CB  1 ? 
ATOM   1615 N N   . MET   A 1 207 ? 10.055  -4.876  17.403  1.000 7.949  0 404  MET   A N   1 ? 
ATOM   1616 C CA  . MET   A 1 207 ? 9.934   -5.685  16.163  1.000 8.197  0 404  MET   A CA  1 ? 
ATOM   1617 C C   . MET   A 1 207 ? 9.244   -7.020  16.484  1.000 7.927  0 404  MET   A C   1 ? 
ATOM   1618 O O   . MET   A 1 207 ? 8.452   -7.484  15.645  1.000 7.807  0 404  MET   A O   1 ? 
ATOM   1619 C CB  . MET   A 1 207 ? 11.285  -5.952  15.496  1.000 8.699  0 404  MET   A CB  1 ? 
ATOM   1620 C CG  . MET   A 1 207 ? 11.118  -6.565  14.118  1.000 8.983  0 404  MET   A CG  1 ? 
ATOM   1621 S SD  . MET   A 1 207 ? 12.622  -6.622  13.130  1.000 10.082 0 404  MET   A SD  1 ? 
ATOM   1622 C CE  . MET   A 1 207 ? 13.556  -7.841  14.050  1.000 10.192 0 404  MET   A CE  1 ? 
ATOM   1623 N N   . GLY   A 1 208 ? 9.521   -7.616  17.648  1.000 7.723  0 405  GLY   A N   1 ? 
ATOM   1624 C CA  . GLY   A 1 208 ? 8.822   -8.835  18.100  1.000 7.550  0 405  GLY   A CA  1 ? 
ATOM   1625 C C   . GLY   A 1 208 ? 7.316   -8.626  18.151  1.000 7.350  0 405  GLY   A C   1 ? 
ATOM   1626 O O   . GLY   A 1 208 ? 6.568   -9.512  17.696  1.000 7.361  0 405  GLY   A O   1 ? 
ATOM   1627 N N   . LEU   A 1 209 ? 6.873   -7.484  18.682  1.000 7.289  0 406  LEU   A N   1 ? 
ATOM   1628 C CA  . LEU   A 1 209 ? 5.429   -7.130  18.749  1.000 7.249  0 406  LEU   A CA  1 ? 
ATOM   1629 C C   . LEU   A 1 209 ? 4.870   -7.033  17.325  1.000 7.367  0 406  LEU   A C   1 ? 
ATOM   1630 O O   . LEU   A 1 209 ? 3.767   -7.545  17.083  1.000 7.421  0 406  LEU   A O   1 ? 
ATOM   1631 C CB  . LEU   A 1 209 ? 5.242   -5.809  19.502  1.000 7.141  0 406  LEU   A CB  1 ? 
ATOM   1632 C CG  . LEU   A 1 209 ? 5.675   -5.788  20.969  1.000 7.072  0 406  LEU   A CG  1 ? 
ATOM   1633 C CD1 . LEU   A 1 209 ? 5.450   -4.409  21.569  1.000 7.103  0 406  LEU   A CD1 1 ? 
ATOM   1634 C CD2 . LEU   A 1 209 ? 4.946   -6.848  21.791  1.000 7.069  0 406  LEU   A CD2 1 ? 
ATOM   1635 N N   . VAL   A 1 210 ? 5.610   -6.407  16.408  1.000 7.334  0 407  VAL   A N   1 ? 
ATOM   1636 C CA  . VAL   A 1 210 ? 5.178   -6.259  14.987  1.000 7.519  0 407  VAL   A CA  1 ? 
ATOM   1637 C C   . VAL   A 1 210 ? 5.053   -7.653  14.354  1.000 7.537  0 407  VAL   A C   1 ? 
ATOM   1638 O O   . VAL   A 1 210 ? 4.075   -7.892  13.632  1.000 7.606  0 407  VAL   A O   1 ? 
ATOM   1639 C CB  . VAL   A 1 210 ? 6.132   -5.352  14.189  1.000 7.565  0 407  VAL   A CB  1 ? 
ATOM   1640 C CG1 . VAL   A 1 210 ? 5.805   -5.379  12.705  1.000 7.690  0 407  VAL   A CG1 1 ? 
ATOM   1641 C CG2 . VAL   A 1 210 ? 6.118   -3.925  14.715  1.000 7.651  0 407  VAL   A CG2 1 ? 
ATOM   1642 N N   . PHE   A 1 211 ? 6.001   -8.556  14.611  1.000 7.536  0 408  PHE   A N   1 ? 
ATOM   1643 C CA  . PHE   A 1 211 ? 5.971   -9.942  14.072  1.000 7.763  0 408  PHE   A CA  1 ? 
ATOM   1644 C C   . PHE   A 1 211 ? 4.685   -10.642 14.528  1.000 7.717  0 408  PHE   A C   1 ? 
ATOM   1645 O O   . PHE   A 1 211 ? 4.066   -11.360 13.725  1.000 7.597  0 408  PHE   A O   1 ? 
ATOM   1646 C CB  . PHE   A 1 211 ? 7.218   -10.715 14.503  1.000 7.982  0 408  PHE   A CB  1 ? 
ATOM   1647 C CG  . PHE   A 1 211 ? 8.453   -10.494 13.665  1.000 8.192  0 408  PHE   A CG  1 ? 
ATOM   1648 C CD1 . PHE   A 1 211 ? 8.618   -9.363  12.876  1.000 8.371  0 408  PHE   A CD1 1 ? 
ATOM   1649 C CD2 . PHE   A 1 211 ? 9.468   -11.435 13.680  1.000 8.442  0 408  PHE   A CD2 1 ? 
ATOM   1650 C CE1 . PHE   A 1 211 ? 9.769   -9.187  12.121  1.000 8.581  0 408  PHE   A CE1 1 ? 
ATOM   1651 C CE2 . PHE   A 1 211 ? 10.621  -11.253 12.932  1.000 8.583  0 408  PHE   A CE2 1 ? 
ATOM   1652 C CZ  . PHE   A 1 211 ? 10.768  -10.132 12.151  1.000 8.564  0 408  PHE   A CZ  1 ? 
ATOM   1653 N N   . TRP   A 1 212 ? 4.292   -10.441 15.786  1.000 7.762  0 409  TRP   A N   1 ? 
ATOM   1654 C CA  . TRP   A 1 212 ? 3.047   -11.015 16.358  1.000 7.887  0 409  TRP   A CA  1 ? 
ATOM   1655 C C   . TRP   A 1 212 ? 1.838   -10.489 15.571  1.000 7.886  0 409  TRP   A C   1 ? 
ATOM   1656 O O   . TRP   A 1 212 ? 0.966   -11.299 15.211  1.000 8.046  0 409  TRP   A O   1 ? 
ATOM   1657 C CB  . TRP   A 1 212 ? 2.985   -10.702 17.855  1.000 7.993  0 409  TRP   A CB  1 ? 
ATOM   1658 C CG  . TRP   A 1 212 ? 1.741   -11.156 18.549  1.000 8.143  0 409  TRP   A CG  1 ? 
ATOM   1659 C CD1 . TRP   A 1 212 ? 1.532   -12.359 19.158  1.000 8.272  0 409  TRP   A CD1 1 ? 
ATOM   1660 C CD2 . TRP   A 1 212 ? 0.543   -10.386 18.749  1.000 8.274  0 409  TRP   A CD2 1 ? 
ATOM   1661 N NE1 . TRP   A 1 212 ? 0.277   -12.395 19.702  1.000 8.417  0 409  TRP   A NE1 1 ? 
ATOM   1662 C CE2 . TRP   A 1 212 ? -0.352  -11.201 19.477  1.000 8.358  0 409  TRP   A CE2 1 ? 
ATOM   1663 C CE3 . TRP   A 1 212 ? 0.138   -9.096  18.386  1.000 8.418  0 409  TRP   A CE3 1 ? 
ATOM   1664 C CZ2 . TRP   A 1 212 ? -1.623  -10.762 19.848  1.000 8.480  0 409  TRP   A CZ2 1 ? 
ATOM   1665 C CZ3 . TRP   A 1 212 ? -1.124  -8.670  18.737  1.000 8.575  0 409  TRP   A CZ3 1 ? 
ATOM   1666 C CH2 . TRP   A 1 212 ? -1.987  -9.490  19.464  1.000 8.509  0 409  TRP   A CH2 1 ? 
ATOM   1667 N N   . GLU   A 1 213 ? 1.808   -9.190  15.257  1.000 7.920  0 410  GLU   A N   1 ? 
ATOM   1668 C CA  . GLU   A 1 213 ? 0.701   -8.578  14.471  1.000 8.024  0 410  GLU   A CA  1 ? 
ATOM   1669 C C   . GLU   A 1 213 ? 0.602   -9.249  13.095  1.000 8.214  0 410  GLU   A C   1 ? 
ATOM   1670 O O   . GLU   A 1 213 ? -0.526  -9.507  12.639  1.000 8.108  0 410  GLU   A O   1 ? 
ATOM   1671 C CB  . GLU   A 1 213 ? 0.911   -7.080  14.273  1.000 7.998  0 410  GLU   A CB  1 ? 
ATOM   1672 C CG  . GLU   A 1 213 ? 0.817   -6.266  15.543  1.000 8.107  0 410  GLU   A CG  1 ? 
ATOM   1673 C CD  . GLU   A 1 213 ? 1.119   -4.802  15.293  1.000 8.258  0 410  GLU   A CD  1 ? 
ATOM   1674 O OE1 . GLU   A 1 213 ? 0.326   -4.160  14.578  1.000 8.502  0 410  GLU   A OE1 1 ? 
ATOM   1675 O OE2 . GLU   A 1 213 ? 2.157   -4.326  15.778  1.000 8.535  0 410  GLU   A OE2 1 ? 
ATOM   1676 N N   . ILE   A 1 214 ? 1.741   -9.506  12.447  1.000 8.367  0 411  ILE   A N   1 ? 
ATOM   1677 C CA  . ILE   A 1 214 ? 1.791   -10.137 11.094  1.000 8.690  0 411  ILE   A CA  1 ? 
ATOM   1678 C C   . ILE   A 1 214 ? 1.285   -11.582 11.192  1.000 8.971  0 411  ILE   A C   1 ? 
ATOM   1679 O O   . ILE   A 1 214 ? 0.420   -11.961 10.382  1.000 9.189  0 411  ILE   A O   1 ? 
ATOM   1680 C CB  . ILE   A 1 214 ? 3.206   -10.078 10.485  1.000 8.599  0 411  ILE   A CB  1 ? 
ATOM   1681 C CG1 . ILE   A 1 214 ? 3.710   -8.643  10.309  1.000 8.637  0 411  ILE   A CG1 1 ? 
ATOM   1682 C CG2 . ILE   A 1 214 ? 3.238   -10.837 9.166   1.000 8.681  0 411  ILE   A CG2 1 ? 
ATOM   1683 C CD1 . ILE   A 1 214 ? 5.190   -8.550  10.039  1.000 8.612  0 411  ILE   A CD1 1 ? 
ATOM   1684 N N   . ALA   A 1 215 ? 1.806   -12.361 12.142  1.000 9.401  0 412  ALA   A N   1 ? 
ATOM   1685 C CA  . ALA   A 1 215 ? 1.553   -13.818 12.250  1.000 9.647  0 412  ALA   A CA  1 ? 
ATOM   1686 C C   . ALA   A 1 215 ? 0.057   -14.087 12.449  1.000 9.957  0 412  ALA   A C   1 ? 
ATOM   1687 O O   . ALA   A 1 215 ? -0.440  -15.092 11.907  1.000 9.937  0 412  ALA   A O   1 ? 
ATOM   1688 C CB  . ALA   A 1 215 ? 2.378   -14.409 13.363  1.000 9.767  0 412  ALA   A CB  1 ? 
ATOM   1689 N N   . ARG   A 1 216 ? -0.641  -13.215 13.177  1.000 10.096 0 413  ARG   A N   1 ? 
ATOM   1690 C CA  . ARG   A 1 216 ? -2.108  -13.331 13.397  1.000 10.535 0 413  ARG   A CA  1 ? 
ATOM   1691 C C   . ARG   A 1 216 ? -2.836  -13.391 12.049  1.000 10.822 0 413  ARG   A C   1 ? 
ATOM   1692 O O   . ARG   A 1 216 ? -3.877  -14.069 11.971  1.000 10.912 0 413  ARG   A O   1 ? 
ATOM   1693 C CB  . ARG   A 1 216 ? -2.627  -12.161 14.235  1.000 10.746 0 413  ARG   A CB  1 ? 
ATOM   1694 C CG  . ARG   A 1 216 ? -2.228  -12.235 15.700  1.000 11.081 0 413  ARG   A CG  1 ? 
ATOM   1695 C CD  . ARG   A 1 216 ? -2.755  -11.050 16.481  1.000 11.408 0 413  ARG   A CD  1 ? 
ATOM   1696 N NE  . ARG   A 1 216 ? -4.208  -11.048 16.552  1.000 11.681 0 413  ARG   A NE  1 ? 
ATOM   1697 C CZ  . ARG   A 1 216 ? -4.930  -11.670 17.481  1.000 11.972 0 413  ARG   A CZ  1 ? 
ATOM   1698 N NH1 . ARG   A 1 216 ? -4.340  -12.356 18.446  1.000 12.262 0 413  ARG   A NH1 1 ? 
ATOM   1699 N NH2 . ARG   A 1 216 ? -6.249  -11.599 17.441  1.000 12.255 0 413  ARG   A NH2 1 ? 
ATOM   1700 N N   . ARG   A 1 217 ? -2.320  -12.691 11.035  1.000 11.000 0 414  ARG   A N   1 ? 
ATOM   1701 C CA  . ARG   A 1 217 ? -3.003  -12.516 9.727   1.000 11.291 0 414  ARG   A CA  1 ? 
ATOM   1702 C C   . ARG   A 1 217 ? -2.548  -13.587 8.732   1.000 11.673 0 414  ARG   A C   1 ? 
ATOM   1703 O O   . ARG   A 1 217 ? -3.046  -13.577 7.595   1.000 11.654 0 414  ARG   A O   1 ? 
ATOM   1704 C CB  . ARG   A 1 217 ? -2.738  -11.105 9.199   1.000 11.315 0 414  ARG   A CB  1 ? 
ATOM   1705 C CG  . ARG   A 1 217 ? -3.148  -10.013 10.175  1.000 11.282 0 414  ARG   A CG  1 ? 
ATOM   1706 C CD  . ARG   A 1 217 ? -4.620  -10.073 10.535  1.000 11.445 0 414  ARG   A CD  1 ? 
ATOM   1707 N NE  . ARG   A 1 217 ? -5.445  -9.649  9.414   1.000 11.566 0 414  ARG   A NE  1 ? 
ATOM   1708 C CZ  . ARG   A 1 217 ? -6.724  -9.963  9.231   1.000 11.709 0 414  ARG   A CZ  1 ? 
ATOM   1709 N NH1 . ARG   A 1 217 ? -7.359  -10.758 10.080  1.000 12.004 0 414  ARG   A NH1 1 ? 
ATOM   1710 N NH2 . ARG   A 1 217 ? -7.362  -9.483  8.179   1.000 12.025 0 414  ARG   A NH2 1 ? 
ATOM   1711 N N   . CYS   A 1 218 ? -1.650  -14.485 9.136   1.000 12.229 0 415  CYS   A N   1 ? 
ATOM   1712 C CA  . CYS   A 1 218 ? -1.213  -15.626 8.297   1.000 13.153 0 415  CYS   A CA  1 ? 
ATOM   1713 C C   . CYS   A 1 218 ? -2.335  -16.671 8.262   1.000 13.865 0 415  CYS   A C   1 ? 
ATOM   1714 O O   . CYS   A 1 218 ? -2.561  -17.331 9.292   1.000 14.031 0 415  CYS   A O   1 ? 
ATOM   1715 C CB  . CYS   A 1 218 ? 0.089   -16.216 8.815   1.000 13.140 0 415  CYS   A CB  1 ? 
ATOM   1716 S SG  . CYS   A 1 218 ? 0.707   -17.546 7.757   1.000 13.900 0 415  CYS   A SG  1 ? 
ATOM   1717 N N   . SER   A 1 219 ? -3.023  -16.785 7.124   1.000 14.781 0 416  SER   A N   1 ? 
ATOM   1718 C CA  . SER   A 1 219 ? -4.224  -17.638 6.936   1.000 16.056 0 416  SER   A CA  1 ? 
ATOM   1719 C C   . SER   A 1 219 ? -3.827  -18.970 6.291   1.000 16.834 0 416  SER   A C   1 ? 
ATOM   1720 O O   . SER   A 1 219 ? -3.320  -18.947 5.153   1.000 17.482 0 416  SER   A O   1 ? 
ATOM   1721 C CB  . SER   A 1 219 ? -5.260  -16.917 6.120   1.000 16.261 0 416  SER   A CB  1 ? 
ATOM   1722 O OG  . SER   A 1 219 ? -6.459  -17.672 6.058   1.000 16.940 0 416  SER   A OG  1 ? 
ATOM   1723 N N   . ILE   A 1 220 ? -4.042  -20.078 7.008   1.000 18.008 0 417  ILE   A N   1 ? 
ATOM   1724 C CA  . ILE   A 1 220 ? -3.763  -21.468 6.539   1.000 19.218 0 417  ILE   A CA  1 ? 
ATOM   1725 C C   . ILE   A 1 220 ? -5.039  -22.296 6.721   1.000 19.882 0 417  ILE   A C   1 ? 
ATOM   1726 O O   . ILE   A 1 220 ? -5.570  -22.324 7.848   1.000 20.427 0 417  ILE   A O   1 ? 
ATOM   1727 C CB  . ILE   A 1 220 ? -2.568  -22.087 7.292   1.000 19.724 0 417  ILE   A CB  1 ? 
ATOM   1728 C CG1 . ILE   A 1 220 ? -1.328  -21.189 7.241   1.000 20.199 0 417  ILE   A CG1 1 ? 
ATOM   1729 C CG2 . ILE   A 1 220 ? -2.276  -23.485 6.763   1.000 20.046 0 417  ILE   A CG2 1 ? 
ATOM   1730 C CD1 . ILE   A 1 220 ? -0.273  -21.542 8.261   1.000 20.476 0 417  ILE   A CD1 1 ? 
ATOM   1731 N N   . GLY   A 1 221 ? -5.499  -22.949 5.649   1.000 20.632 0 418  GLY   A N   1 ? 
ATOM   1732 C CA  . GLY   A 1 221 ? -6.778  -23.686 5.616   1.000 20.934 0 418  GLY   A CA  1 ? 
ATOM   1733 C C   . GLY   A 1 221 ? -7.950  -22.792 5.987   1.000 21.219 0 418  GLY   A C   1 ? 
ATOM   1734 O O   . GLY   A 1 221 ? -8.898  -23.301 6.614   1.000 21.676 0 418  GLY   A O   1 ? 
ATOM   1735 N N   . GLY   A 1 222 ? -7.872  -21.502 5.635   1.000 21.212 0 419  GLY   A N   1 ? 
ATOM   1736 C CA  . GLY   A 1 222 ? -8.917  -20.488 5.880   1.000 20.842 0 419  GLY   A CA  1 ? 
ATOM   1737 C C   . GLY   A 1 222 ? -8.932  -19.984 7.316   1.000 20.392 0 419  GLY   A C   1 ? 
ATOM   1738 O O   . GLY   A 1 222 ? -9.820  -19.171 7.637   1.000 21.027 0 419  GLY   A O   1 ? 
ATOM   1739 N N   . ILE   A 1 223 ? -7.981  -20.424 8.148   1.000 19.339 0 420  ILE   A N   1 ? 
ATOM   1740 C CA  . ILE   A 1 223 ? -7.932  -20.128 9.611   1.000 18.803 0 420  ILE   A CA  1 ? 
ATOM   1741 C C   . ILE   A 1 223 ? -6.882  -19.042 9.861   1.000 17.428 0 420  ILE   A C   1 ? 
ATOM   1742 O O   . ILE   A 1 223 ? -5.734  -19.211 9.419   1.000 16.880 0 420  ILE   A O   1 ? 
ATOM   1743 C CB  . ILE   A 1 223 ? -7.637  -21.399 10.434  1.000 19.602 0 420  ILE   A CB  1 ? 
ATOM   1744 C CG1 . ILE   A 1 223 ? -8.570  -22.558 10.069  1.000 20.152 0 420  ILE   A CG1 1 ? 
ATOM   1745 C CG2 . ILE   A 1 223 ? -7.677  -21.095 11.925  1.000 19.892 0 420  ILE   A CG2 1 ? 
ATOM   1746 C CD1 . ILE   A 1 223 ? -10.039 -22.258 10.255  1.000 20.398 0 420  ILE   A CD1 1 ? 
ATOM   1747 N N   . HIS   A 1 224 ? -7.275  -17.982 10.567  1.000 16.404 0 421  HIS   A N   1 ? 
ATOM   1748 C CA  . HIS   A 1 224 ? -6.397  -16.863 10.999  1.000 15.896 0 421  HIS   A CA  1 ? 
ATOM   1749 C C   . HIS   A 1 224 ? -7.063  -16.143 12.169  1.000 15.167 0 421  HIS   A C   1 ? 
ATOM   1750 O O   . HIS   A 1 224 ? -8.256  -16.399 12.421  1.000 15.161 0 421  HIS   A O   1 ? 
ATOM   1751 C CB  . HIS   A 1 224 ? -6.129  -15.901 9.836   1.000 16.051 0 421  HIS   A CB  1 ? 
ATOM   1752 C CG  . HIS   A 1 224 ? -7.372  -15.441 9.154   1.000 16.165 0 421  HIS   A CG  1 ? 
ATOM   1753 N ND1 . HIS   A 1 224 ? -8.067  -14.317 9.557   1.000 16.715 0 421  HIS   A ND1 1 ? 
ATOM   1754 C CD2 . HIS   A 1 224 ? -8.059  -15.959 8.114   1.000 16.222 0 421  HIS   A CD2 1 ? 
ATOM   1755 C CE1 . HIS   A 1 224 ? -9.124  -14.160 8.785   1.000 16.458 0 421  HIS   A CE1 1 ? 
ATOM   1756 N NE2 . HIS   A 1 224 ? -9.141  -15.153 7.893   1.000 16.867 0 421  HIS   A NE2 1 ? 
ATOM   1757 N N   . GLU   A 1 225 ? -6.319  -15.271 12.848  1.000 14.279 0 422  GLU   A N   1 ? 
ATOM   1758 C CA  . GLU   A 1 225 ? -6.844  -14.422 13.946  1.000 14.101 0 422  GLU   A CA  1 ? 
ATOM   1759 C C   . GLU   A 1 225 ? -7.293  -13.079 13.362  1.000 13.686 0 422  GLU   A C   1 ? 
ATOM   1760 O O   . GLU   A 1 225 ? -6.801  -12.697 12.277  1.000 13.554 0 422  GLU   A O   1 ? 
ATOM   1761 C CB  . GLU   A 1 225 ? -5.784  -14.234 15.034  1.000 14.183 0 422  GLU   A CB  1 ? 
ATOM   1762 C CG  . GLU   A 1 225 ? -5.505  -15.494 15.841  1.000 14.489 0 422  GLU   A CG  1 ? 
ATOM   1763 C CD  . GLU   A 1 225 ? -4.596  -16.511 15.172  1.000 14.755 0 422  GLU   A CD  1 ? 
ATOM   1764 O OE1 . GLU   A 1 225 ? -3.612  -16.097 14.531  1.000 14.303 0 422  GLU   A OE1 1 ? 
ATOM   1765 O OE2 . GLU   A 1 225 ? -4.872  -17.720 15.292  1.000 15.375 0 422  GLU   A OE2 1 ? 
ATOM   1766 N N   . ASP   A 1 226 ? -8.207  -12.395 14.051  1.000 13.659 0 423  ASP   A N   1 ? 
ATOM   1767 C CA  . ASP   A 1 226 ? -8.591  -10.996 13.731  1.000 13.763 0 423  ASP   A CA  1 ? 
ATOM   1768 C C   . ASP   A 1 226 ? -7.354  -10.115 13.906  1.000 12.378 0 423  ASP   A C   1 ? 
ATOM   1769 O O   . ASP   A 1 226 ? -6.500  -10.450 14.752  1.000 12.032 0 423  ASP   A O   1 ? 
ATOM   1770 C CB  . ASP   A 1 226 ? -9.703  -10.470 14.641  1.000 15.388 0 423  ASP   A CB  1 ? 
ATOM   1771 C CG  . ASP   A 1 226 ? -10.986 -11.279 14.606  1.000 17.333 0 423  ASP   A CG  1 ? 
ATOM   1772 O OD1 . ASP   A 1 226 ? -11.303 -11.832 13.533  1.000 18.899 0 423  ASP   A OD1 1 ? 
ATOM   1773 O OD2 . ASP   A 1 226 ? -11.656 -11.347 15.657  1.000 20.433 0 423  ASP   A OD2 1 ? 
ATOM   1774 N N   . TYR   A 1 227 ? -7.256  -9.020  13.153  1.000 10.977 0 424  TYR   A N   1 ? 
ATOM   1775 C CA  . TYR   A 1 227 ? -6.197  -8.015  13.404  1.000 10.368 0 424  TYR   A CA  1 ? 
ATOM   1776 C C   . TYR   A 1 227 ? -6.361  -7.488  14.837  1.000 10.023 0 424  TYR   A C   1 ? 
ATOM   1777 O O   . TYR   A 1 227 ? -7.482  -7.127  15.232  1.000 9.956  0 424  TYR   A O   1 ? 
ATOM   1778 C CB  . TYR   A 1 227 ? -6.195  -6.830  12.430  1.000 10.052 0 424  TYR   A CB  1 ? 
ATOM   1779 C CG  . TYR   A 1 227 ? -5.157  -5.859  12.914  1.000 9.791  0 424  TYR   A CG  1 ? 
ATOM   1780 C CD1 . TYR   A 1 227 ? -3.818  -6.062  12.628  1.000 9.766  0 424  TYR   A CD1 1 ? 
ATOM   1781 C CD2 . TYR   A 1 227 ? -5.481  -4.894  13.853  1.000 9.726  0 424  TYR   A CD2 1 ? 
ATOM   1782 C CE1 . TYR   A 1 227 ? -2.835  -5.262  13.187  1.000 9.658  0 424  TYR   A CE1 1 ? 
ATOM   1783 C CE2 . TYR   A 1 227 ? -4.514  -4.084  14.419  1.000 9.704  0 424  TYR   A CE2 1 ? 
ATOM   1784 C CZ  . TYR   A 1 227 ? -3.185  -4.268  14.085  1.000 9.669  0 424  TYR   A CZ  1 ? 
ATOM   1785 O OH  . TYR   A 1 227 ? -2.238  -3.486  14.673  1.000 10.056 0 424  TYR   A OH  1 ? 
ATOM   1786 N N   . GLN   A 1 228 ? -5.271  -7.439  15.604  1.000 9.616  0 425  GLN   A N   1 ? 
ATOM   1787 C CA  . GLN   A 1 228 ? -5.224  -6.689  16.886  1.000 9.660  0 425  GLN   A CA  1 ? 
ATOM   1788 C C   . GLN   A 1 228 ? -3.850  -6.040  17.055  1.000 9.173  0 425  GLN   A C   1 ? 
ATOM   1789 O O   . GLN   A 1 228 ? -2.854  -6.587  16.545  1.000 8.882  0 425  GLN   A O   1 ? 
ATOM   1790 C CB  . GLN   A 1 228 ? -5.482  -7.590  18.098  1.000 10.147 0 425  GLN   A CB  1 ? 
ATOM   1791 C CG  . GLN   A 1 228 ? -6.857  -8.248  18.133  1.000 10.652 0 425  GLN   A CG  1 ? 
ATOM   1792 C CD  . GLN   A 1 228 ? -8.007  -7.298  18.368  1.000 11.116 0 425  GLN   A CD  1 ? 
ATOM   1793 O OE1 . GLN   A 1 228 ? -7.836  -6.118  18.664  1.000 11.569 0 425  GLN   A OE1 1 ? 
ATOM   1794 N NE2 . GLN   A 1 228 ? -9.216  -7.822  18.253  1.000 11.881 0 425  GLN   A NE2 1 ? 
ATOM   1795 N N   . LEU   A 1 229 ? -3.814  -4.920  17.774  1.000 8.881  0 426  LEU   A N   1 ? 
ATOM   1796 C CA  . LEU   A 1 229 ? -2.564  -4.330  18.310  1.000 8.916  0 426  LEU   A CA  1 ? 
ATOM   1797 C C   . LEU   A 1 229 ? -2.054  -5.208  19.449  1.000 8.665  0 426  LEU   A C   1 ? 
ATOM   1798 O O   . LEU   A 1 229 ? -2.834  -5.855  20.154  1.000 8.449  0 426  LEU   A O   1 ? 
ATOM   1799 C CB  . LEU   A 1 229 ? -2.843  -2.909  18.809  1.000 9.155  0 426  LEU   A CB  1 ? 
ATOM   1800 C CG  . LEU   A 1 229 ? -2.981  -1.843  17.724  1.000 9.470  0 426  LEU   A CG  1 ? 
ATOM   1801 C CD1 . LEU   A 1 229 ? -3.677  -0.604  18.267  1.000 9.739  0 426  LEU   A CD1 1 ? 
ATOM   1802 C CD2 . LEU   A 1 229 ? -1.620  -1.481  17.152  1.000 9.612  0 426  LEU   A CD2 1 ? 
ATOM   1803 N N   . PRO   A 1 230 ? -0.730  -5.233  19.705  1.000 8.482  0 427  PRO   A N   1 ? 
ATOM   1804 C CA  . PRO   A 1 230 ? -0.205  -5.965  20.853  1.000 8.563  0 427  PRO   A CA  1 ? 
ATOM   1805 C C   . PRO   A 1 230 ? -0.804  -5.379  22.140  1.000 8.452  0 427  PRO   A C   1 ? 
ATOM   1806 O O   . PRO   A 1 230 ? -0.923  -4.171  22.234  1.000 8.253  0 427  PRO   A O   1 ? 
ATOM   1807 C CB  . PRO   A 1 230 ? 1.313   -5.758  20.772  1.000 8.551  0 427  PRO   A CB  1 ? 
ATOM   1808 C CG  . PRO   A 1 230 ? 1.477   -4.502  19.935  1.000 8.582  0 427  PRO   A CG  1 ? 
ATOM   1809 C CD  . PRO   A 1 230 ? 0.318   -4.520  18.960  1.000 8.537  0 427  PRO   A CD  1 ? 
ATOM   1810 N N   . TYR   A 1 231 ? -1.201  -6.248  23.075  1.000 8.603  0 428  TYR   A N   1 ? 
ATOM   1811 C CA  . TYR   A 1 231 ? -1.772  -5.890  24.402  1.000 8.792  0 428  TYR   A CA  1 ? 
ATOM   1812 C C   . TYR   A 1 231 ? -3.204  -5.355  24.263  1.000 9.165  0 428  TYR   A C   1 ? 
ATOM   1813 O O   . TYR   A 1 231 ? -3.689  -4.762  25.240  1.000 9.155  0 428  TYR   A O   1 ? 
ATOM   1814 C CB  . TYR   A 1 231 ? -0.865  -4.896  25.134  1.000 8.736  0 428  TYR   A CB  1 ? 
ATOM   1815 C CG  . TYR   A 1 231 ? 0.537   -5.408  25.332  1.000 8.495  0 428  TYR   A CG  1 ? 
ATOM   1816 C CD1 . TYR   A 1 231 ? 0.789   -6.435  26.227  1.000 8.475  0 428  TYR   A CD1 1 ? 
ATOM   1817 C CD2 . TYR   A 1 231 ? 1.604   -4.898  24.611  1.000 8.391  0 428  TYR   A CD2 1 ? 
ATOM   1818 C CE1 . TYR   A 1 231 ? 2.065   -6.935  26.410  1.000 8.446  0 428  TYR   A CE1 1 ? 
ATOM   1819 C CE2 . TYR   A 1 231 ? 2.890   -5.384  24.786  1.000 8.314  0 428  TYR   A CE2 1 ? 
ATOM   1820 C CZ  . TYR   A 1 231 ? 3.120   -6.406  25.691  1.000 8.348  0 428  TYR   A CZ  1 ? 
ATOM   1821 O OH  . TYR   A 1 231 ? 4.375   -6.903  25.874  1.000 8.375  0 428  TYR   A OH  1 ? 
ATOM   1822 N N   . TYR   A 1 232 ? -3.879  -5.600  23.133  1.000 9.652  0 429  TYR   A N   1 ? 
ATOM   1823 C CA  . TYR   A 1 232 ? -5.310  -5.246  22.917  1.000 10.324 0 429  TYR   A CA  1 ? 
ATOM   1824 C C   . TYR   A 1 232 ? -6.159  -5.820  24.058  1.000 10.760 0 429  TYR   A C   1 ? 
ATOM   1825 O O   . TYR   A 1 232 ? -7.228  -5.261  24.351  1.000 11.421 0 429  TYR   A O   1 ? 
ATOM   1826 C CB  . TYR   A 1 232 ? -5.829  -5.795  21.584  1.000 10.522 0 429  TYR   A CB  1 ? 
ATOM   1827 C CG  . TYR   A 1 232 ? -6.114  -7.276  21.595  1.000 10.739 0 429  TYR   A CG  1 ? 
ATOM   1828 C CD1 . TYR   A 1 232 ? -5.094  -8.206  21.470  1.000 10.859 0 429  TYR   A CD1 1 ? 
ATOM   1829 C CD2 . TYR   A 1 232 ? -7.406  -7.754  21.760  1.000 10.900 0 429  TYR   A CD2 1 ? 
ATOM   1830 C CE1 . TYR   A 1 232 ? -5.350  -9.568  21.493  1.000 11.166 0 429  TYR   A CE1 1 ? 
ATOM   1831 C CE2 . TYR   A 1 232 ? -7.676  -9.112  21.793  1.000 11.359 0 429  TYR   A CE2 1 ? 
ATOM   1832 C CZ  . TYR   A 1 232 ? -6.645  -10.023 21.659  1.000 11.539 0 429  TYR   A CZ  1 ? 
ATOM   1833 O OH  . TYR   A 1 232 ? -6.899  -11.364 21.688  1.000 12.515 0 429  TYR   A OH  1 ? 
ATOM   1834 N N   . ASP   A 1 233 ? -5.688  -6.919  24.658  1.000 11.301 0 430  ASP   A N   1 ? 
ATOM   1835 C CA  . ASP   A 1 233 ? -6.426  -7.769  25.629  1.000 11.823 0 430  ASP   A CA  1 ? 
ATOM   1836 C C   . ASP   A 1 233 ? -6.103  -7.365  27.073  1.000 11.952 0 430  ASP   A C   1 ? 
ATOM   1837 O O   . ASP   A 1 233 ? -6.656  -8.006  27.984  1.000 12.632 0 430  ASP   A O   1 ? 
ATOM   1838 C CB  . ASP   A 1 233 ? -6.101  -9.249  25.393  1.000 12.120 0 430  ASP   A CB  1 ? 
ATOM   1839 C CG  . ASP   A 1 233 ? -4.617  -9.596  25.314  1.000 12.358 0 430  ASP   A CG  1 ? 
ATOM   1840 O OD1 . ASP   A 1 233 ? -3.777  -8.664  25.277  1.000 12.587 0 430  ASP   A OD1 1 ? 
ATOM   1841 O OD2 . ASP   A 1 233 ? -4.308  -10.801 25.277  1.000 12.912 0 430  ASP   A OD2 1 ? 
ATOM   1842 N N   . LEU   A 1 234 ? -5.250  -6.358  27.288  1.000 11.736 0 431  LEU   A N   1 ? 
ATOM   1843 C CA  . LEU   A 1 234 ? -4.675  -6.069  28.632  1.000 11.650 0 431  LEU   A CA  1 ? 
ATOM   1844 C C   . LEU   A 1 234 ? -4.646  -4.571  28.968  1.000 11.631 0 431  LEU   A C   1 ? 
ATOM   1845 O O   . LEU   A 1 234 ? -4.541  -4.268  30.171  1.000 11.780 0 431  LEU   A O   1 ? 
ATOM   1846 C CB  . LEU   A 1 234 ? -3.267  -6.669  28.686  1.000 11.654 0 431  LEU   A CB  1 ? 
ATOM   1847 C CG  . LEU   A 1 234 ? -3.210  -8.193  28.773  1.000 11.786 0 431  LEU   A CG  1 ? 
ATOM   1848 C CD1 . LEU   A 1 234 ? -1.806  -8.702  28.482  1.000 11.808 0 431  LEU   A CD1 1 ? 
ATOM   1849 C CD2 . LEU   A 1 234 ? -3.687  -8.683  30.134  1.000 11.936 0 431  LEU   A CD2 1 ? 
ATOM   1850 N N   . VAL   A 1 235 ? -4.691  -3.667  27.984  1.000 11.408 0 432  VAL   A N   1 ? 
ATOM   1851 C CA  . VAL   A 1 235 ? -4.576  -2.199  28.231  1.000 11.642 0 432  VAL   A CA  1 ? 
ATOM   1852 C C   . VAL   A 1 235 ? -5.649  -1.463  27.438  1.000 12.133 0 432  VAL   A C   1 ? 
ATOM   1853 O O   . VAL   A 1 235 ? -6.149  -1.973  26.438  1.000 11.715 0 432  VAL   A O   1 ? 
ATOM   1854 C CB  . VAL   A 1 235 ? -3.168  -1.663  27.901  1.000 11.440 0 432  VAL   A CB  1 ? 
ATOM   1855 C CG1 . VAL   A 1 235 ? -2.094  -2.391  28.697  1.000 11.430 0 432  VAL   A CG1 1 ? 
ATOM   1856 C CG2 . VAL   A 1 235 ? -2.864  -1.708  26.409  1.000 11.387 0 432  VAL   A CG2 1 ? 
ATOM   1857 N N   . PRO   A 1 236 ? -6.018  -0.231  27.855  1.000 13.001 0 433  PRO   A N   1 ? 
ATOM   1858 C CA  . PRO   A 1 236 ? -6.964  0.577   27.092  1.000 13.430 0 433  PRO   A CA  1 ? 
ATOM   1859 C C   . PRO   A 1 236 ? -6.343  1.030   25.764  1.000 13.826 0 433  PRO   A C   1 ? 
ATOM   1860 O O   . PRO   A 1 236 ? -5.135  0.954   25.609  1.000 13.740 0 433  PRO   A O   1 ? 
ATOM   1861 C CB  . PRO   A 1 236 ? -7.254  1.797   27.983  1.000 13.691 0 433  PRO   A CB  1 ? 
ATOM   1862 C CG  . PRO   A 1 236 ? -6.660  1.459   29.338  1.000 13.664 0 433  PRO   A CG  1 ? 
ATOM   1863 C CD  . PRO   A 1 236 ? -5.559  0.455   29.071  1.000 13.397 0 433  PRO   A CD  1 ? 
ATOM   1864 N N   . SER   A 1 237 ? -7.178  1.500   24.837  1.000 14.168 0 434  SER   A N   1 ? 
ATOM   1865 C CA  . SER   A 1 237 ? -6.726  2.255   23.642  1.000 14.716 0 434  SER   A CA  1 ? 
ATOM   1866 C C   . SER   A 1 237 ? -5.975  3.502   24.126  1.000 14.919 0 434  SER   A C   1 ? 
ATOM   1867 O O   . SER   A 1 237 ? -6.372  4.067   25.166  1.000 15.765 0 434  SER   A O   1 ? 
ATOM   1868 C CB  . SER   A 1 237 ? -7.882  2.600   22.740  1.000 14.791 0 434  SER   A CB  1 ? 
ATOM   1869 O OG  . SER   A 1 237 ? -8.657  1.444   22.456  1.000 15.248 0 434  SER   A OG  1 ? 
ATOM   1870 N N   . ASP   A 1 238 ? -4.898  3.875   23.434  1.000 15.201 0 435  ASP   A N   1 ? 
ATOM   1871 C CA  . ASP   A 1 238 ? -4.010  5.008   23.802  1.000 15.070 0 435  ASP   A CA  1 ? 
ATOM   1872 C C   . ASP   A 1 238 ? -3.558  4.845   25.253  1.000 14.360 0 435  ASP   A C   1 ? 
ATOM   1873 O O   . ASP   A 1 238 ? -3.804  5.715   26.088  1.000 15.016 0 435  ASP   A O   1 ? 
ATOM   1874 C CB  . ASP   A 1 238 ? -4.713  6.348   23.566  1.000 15.892 0 435  ASP   A CB  1 ? 
ATOM   1875 C CG  . ASP   A 1 238 ? -3.777  7.542   23.605  1.000 16.846 0 435  ASP   A CG  1 ? 
ATOM   1876 O OD1 . ASP   A 1 238 ? -2.568  7.348   23.368  1.000 17.273 0 435  ASP   A OD1 1 ? 
ATOM   1877 O OD2 . ASP   A 1 238 ? -4.266  8.663   23.869  1.000 18.563 0 435  ASP   A OD2 1 ? 
ATOM   1878 N N   . PRO   A 1 239 ? -2.876  3.729   25.600  1.000 13.198 0 436  PRO   A N   1 ? 
ATOM   1879 C CA  . PRO   A 1 239 ? -2.506  3.454   26.989  1.000 12.857 0 436  PRO   A CA  1 ? 
ATOM   1880 C C   . PRO   A 1 239 ? -1.429  4.411   27.520  1.000 12.656 0 436  PRO   A C   1 ? 
ATOM   1881 O O   . PRO   A 1 239 ? -0.638  4.908   26.743  1.000 12.875 0 436  PRO   A O   1 ? 
ATOM   1882 C CB  . PRO   A 1 239 ? -1.980  2.012   26.924  1.000 12.676 0 436  PRO   A CB  1 ? 
ATOM   1883 C CG  . PRO   A 1 239 ? -1.437  1.886   25.521  1.000 12.656 0 436  PRO   A CG  1 ? 
ATOM   1884 C CD  . PRO   A 1 239 ? -2.405  2.685   24.676  1.000 12.747 0 436  PRO   A CD  1 ? 
ATOM   1885 N N   . SER   A 1 240 ? -1.430  4.649   28.833  1.000 12.491 0 437  SER   A N   1 ? 
ATOM   1886 C CA  . SER   A 1 240 ? -0.399  5.447   29.544  1.000 12.609 0 437  SER   A CA  1 ? 
ATOM   1887 C C   . SER   A 1 240 ? 0.841   4.582   29.789  1.000 12.475 0 437  SER   A C   1 ? 
ATOM   1888 O O   . SER   A 1 240 ? 0.740   3.342   29.702  1.000 12.215 0 437  SER   A O   1 ? 
ATOM   1889 C CB  . SER   A 1 240 ? -0.932  5.990   30.838  1.000 12.702 0 437  SER   A CB  1 ? 
ATOM   1890 O OG  . SER   A 1 240 ? -1.119  4.939   31.773  1.000 12.990 0 437  SER   A OG  1 ? 
ATOM   1891 N N   . VAL   A 1 241 ? 1.965   5.218   30.118  1.000 12.431 0 438  VAL   A N   1 ? 
ATOM   1892 C CA  . VAL   A 1 241 ? 3.218   4.521   30.529  1.000 12.821 0 438  VAL   A CA  1 ? 
ATOM   1893 C C   . VAL   A 1 241 ? 2.899   3.631   31.737  1.000 12.796 0 438  VAL   A C   1 ? 
ATOM   1894 O O   . VAL   A 1 241 ? 3.337   2.467   31.743  1.000 12.495 0 438  VAL   A O   1 ? 
ATOM   1895 C CB  . VAL   A 1 241 ? 4.349   5.525   30.826  1.000 12.843 0 438  VAL   A CB  1 ? 
ATOM   1896 C CG1 . VAL   A 1 241 ? 5.525   4.861   31.524  1.000 13.073 0 438  VAL   A CG1 1 ? 
ATOM   1897 C CG2 . VAL   A 1 241 ? 4.807   6.246   29.564  1.000 13.083 0 438  VAL   A CG2 1 ? 
ATOM   1898 N N   . GLU   A 1 242 ? 2.138   4.141   32.708  1.000 13.154 0 439  GLU   A N   1 ? 
ATOM   1899 C CA  . GLU   A 1 242 ? 1.822   3.405   33.962  1.000 13.665 0 439  GLU   A CA  1 ? 
ATOM   1900 C C   . GLU   A 1 242 ? 0.985   2.160   33.640  1.000 12.778 0 439  GLU   A C   1 ? 
ATOM   1901 O O   . GLU   A 1 242 ? 1.299   1.085   34.185  1.000 12.498 0 439  GLU   A O   1 ? 
ATOM   1902 C CB  . GLU   A 1 242 ? 1.142   4.335   34.969  1.000 15.038 0 439  GLU   A CB  1 ? 
ATOM   1903 C CG  . GLU   A 1 242 ? 2.132   5.196   35.730  1.000 16.435 0 439  GLU   A CG  1 ? 
ATOM   1904 C CD  . GLU   A 1 242 ? 3.153   4.400   36.527  1.000 17.688 0 439  GLU   A CD  1 ? 
ATOM   1905 O OE1 . GLU   A 1 242 ? 4.344   4.398   36.141  1.000 19.500 0 439  GLU   A OE1 1 ? 
ATOM   1906 O OE2 . GLU   A 1 242 ? 2.753   3.771   37.527  1.000 20.015 0 439  GLU   A OE2 1 ? 
ATOM   1907 N N   . GLU   A 1 243 ? -0.024  2.281   32.776  1.000 12.278 0 440  GLU   A N   1 ? 
ATOM   1908 C CA  . GLU   A 1 243 ? -0.868  1.132   32.350  1.000 12.026 0 440  GLU   A CA  1 ? 
ATOM   1909 C C   . GLU   A 1 243 ? 0.021   0.071   31.689  1.000 11.300 0 440  GLU   A C   1 ? 
ATOM   1910 O O   . GLU   A 1 243 ? -0.109  -1.115  32.037  1.000 11.181 0 440  GLU   A O   1 ? 
ATOM   1911 C CB  . GLU   A 1 243 ? -1.992  1.612   31.431  1.000 12.626 0 440  GLU   A CB  1 ? 
ATOM   1912 C CG  . GLU   A 1 243 ? -3.065  2.383   32.179  1.000 13.209 0 440  GLU   A CG  1 ? 
ATOM   1913 C CD  . GLU   A 1 243 ? -4.042  3.177   31.329  1.000 13.946 0 440  GLU   A CD  1 ? 
ATOM   1914 O OE1 . GLU   A 1 243 ? -3.733  3.451   30.150  1.000 14.256 0 440  GLU   A OE1 1 ? 
ATOM   1915 O OE2 . GLU   A 1 243 ? -5.122  3.524   31.856  1.000 15.428 0 440  GLU   A OE2 1 ? 
ATOM   1916 N N   . MET   A 1 244 ? 0.911   0.483   30.785  1.000 10.579 0 441  MET   A N   1 ? 
ATOM   1917 C CA  . MET   A 1 244 ? 1.835   -0.442  30.077  1.000 10.341 0 441  MET   A CA  1 ? 
ATOM   1918 C C   . MET   A 1 244 ? 2.805   -1.074  31.083  1.000 10.156 0 441  MET   A C   1 ? 
ATOM   1919 O O   . MET   A 1 244 ? 2.991   -2.300  31.030  1.000 9.631  0 441  MET   A O   1 ? 
ATOM   1920 C CB  . MET   A 1 244 ? 2.628   0.290   28.993  1.000 10.072 0 441  MET   A CB  1 ? 
ATOM   1921 C CG  . MET   A 1 244 ? 1.790   0.733   27.803  1.000 10.036 0 441  MET   A CG  1 ? 
ATOM   1922 S SD  . MET   A 1 244 ? 0.823   -0.595  27.034  1.000 9.969  0 441  MET   A SD  1 ? 
ATOM   1923 C CE  . MET   A 1 244 ? 2.083   -1.840  26.769  1.000 10.179 0 441  MET   A CE  1 ? 
ATOM   1924 N N   . ARG   A 1 245 ? 3.390   -0.273  31.975  1.000 10.457 0 442  ARG   A N   1 ? 
ATOM   1925 C CA  . ARG   A 1 245 ? 4.399   -0.746  32.960  1.000 11.073 0 442  ARG   A CA  1 ? 
ATOM   1926 C C   . ARG   A 1 245 ? 3.785   -1.833  33.853  1.000 10.727 0 442  ARG   A C   1 ? 
ATOM   1927 O O   . ARG   A 1 245 ? 4.460   -2.840  34.109  1.000 10.456 0 442  ARG   A O   1 ? 
ATOM   1928 C CB  . ARG   A 1 245 ? 4.924   0.420   33.801  1.000 11.785 0 442  ARG   A CB  1 ? 
ATOM   1929 C CG  . ARG   A 1 245 ? 6.155   0.070   34.627  1.000 12.700 0 442  ARG   A CG  1 ? 
ATOM   1930 C CD  . ARG   A 1 245 ? 6.519   1.145   35.634  1.000 13.732 0 442  ARG   A CD  1 ? 
ATOM   1931 N NE  . ARG   A 1 245 ? 5.380   1.507   36.465  1.000 14.858 0 442  ARG   A NE  1 ? 
ATOM   1932 C CZ  . ARG   A 1 245 ? 4.859   0.749   37.429  1.000 15.862 0 442  ARG   A CZ  1 ? 
ATOM   1933 N NH1 . ARG   A 1 245 ? 5.380   -0.433  37.719  1.000 16.455 0 442  ARG   A NH1 1 ? 
ATOM   1934 N NH2 . ARG   A 1 245 ? 3.810   1.182   38.108  1.000 16.698 0 442  ARG   A NH2 1 ? 
ATOM   1935 N N   . LYS   A 1 246 ? 2.548   -1.649  34.314  1.000 10.598 0 443  LYS   A N   1 ? 
ATOM   1936 C CA  . LYS   A 1 246 ? 1.893   -2.608  35.243  1.000 10.858 0 443  LYS   A CA  1 ? 
ATOM   1937 C C   . LYS   A 1 246 ? 1.712   -3.962  34.544  1.000 10.201 0 443  LYS   A C   1 ? 
ATOM   1938 O O   . LYS   A 1 246 ? 1.836   -4.999  35.223  1.000 9.899  0 443  LYS   A O   1 ? 
ATOM   1939 C CB  . LYS   A 1 246 ? 0.583   -2.017  35.768  1.000 11.768 0 443  LYS   A CB  1 ? 
ATOM   1940 C CG  . LYS   A 1 246 ? 0.784   -0.883  36.764  1.000 12.713 0 443  LYS   A CG  1 ? 
ATOM   1941 C CD  . LYS   A 1 246 ? -0.457  -0.094  37.100  1.000 13.849 0 443  LYS   A CD  1 ? 
ATOM   1942 C CE  . LYS   A 1 246 ? -0.151  1.055   38.039  1.000 14.786 0 443  LYS   A CE  1 ? 
ATOM   1943 N NZ  . LYS   A 1 246 ? -1.363  1.824   38.398  1.000 15.769 0 443  LYS   A NZ  1 ? 
ATOM   1944 N N   . VAL   A 1 247 ? 1.452   -3.968  33.234  1.000 9.739  0 444  VAL   A N   1 ? 
ATOM   1945 C CA  . VAL   A 1 247 ? 1.237   -5.222  32.456  1.000 9.630  0 444  VAL   A CA  1 ? 
ATOM   1946 C C   . VAL   A 1 247 ? 2.596   -5.831  32.090  1.000 9.532  0 444  VAL   A C   1 ? 
ATOM   1947 O O   . VAL   A 1 247 ? 2.796   -7.028  32.350  1.000 9.403  0 444  VAL   A O   1 ? 
ATOM   1948 C CB  . VAL   A 1 247 ? 0.373   -4.961  31.208  1.000 9.491  0 444  VAL   A CB  1 ? 
ATOM   1949 C CG1 . VAL   A 1 247 ? 0.366   -6.150  30.259  1.000 9.540  0 444  VAL   A CG1 1 ? 
ATOM   1950 C CG2 . VAL   A 1 247 ? -1.044  -4.571  31.596  1.000 9.596  0 444  VAL   A CG2 1 ? 
ATOM   1951 N N   . VAL   A 1 248 ? 3.486   -5.041  31.491  1.000 9.838  0 445  VAL   A N   1 ? 
ATOM   1952 C CA  . VAL   A 1 248 ? 4.734   -5.544  30.849  1.000 10.117 0 445  VAL   A CA  1 ? 
ATOM   1953 C C   . VAL   A 1 248 ? 5.801   -5.820  31.918  1.000 10.662 0 445  VAL   A C   1 ? 
ATOM   1954 O O   . VAL   A 1 248 ? 6.483   -6.852  31.807  1.000 10.723 0 445  VAL   A O   1 ? 
ATOM   1955 C CB  . VAL   A 1 248 ? 5.219   -4.556  29.770  1.000 10.063 0 445  VAL   A CB  1 ? 
ATOM   1956 C CG1 . VAL   A 1 248 ? 6.583   -4.925  29.211  1.000 10.204 0 445  VAL   A CG1 1 ? 
ATOM   1957 C CG2 . VAL   A 1 248 ? 4.201   -4.439  28.647  1.000 10.099 0 445  VAL   A CG2 1 ? 
ATOM   1958 N N   . CYS   A 1 249 ? 5.943   -4.943  32.914  1.000 11.311 0 446  CYS   A N   1 ? 
ATOM   1959 C CA  . CYS   A 1 249 ? 7.045   -4.996  33.913  1.000 12.157 0 446  CYS   A CA  1 ? 
ATOM   1960 C C   . CYS   A 1 249 ? 6.610   -5.729  35.188  1.000 12.264 0 446  CYS   A C   1 ? 
ATOM   1961 O O   . CYS   A 1 249 ? 7.397   -6.557  35.671  1.000 13.378 0 446  CYS   A O   1 ? 
ATOM   1962 C CB  . CYS   A 1 249 ? 7.541   -3.598  34.254  1.000 12.687 0 446  CYS   A CB  1 ? 
ATOM   1963 S SG  . CYS   A 1 249 ? 8.214   -2.715  32.824  1.000 14.006 0 446  CYS   A SG  1 ? 
ATOM   1964 N N   . GLU   A 1 250 ? 5.424   -5.433  35.730  1.000 12.280 0 447  GLU   A N   1 ? 
ATOM   1965 C CA  . GLU   A 1 250 ? 4.972   -5.983  37.038  1.000 12.574 0 447  GLU   A CA  1 ? 
ATOM   1966 C C   . GLU   A 1 250 ? 4.346   -7.368  36.837  1.000 12.167 0 447  GLU   A C   1 ? 
ATOM   1967 O O   . GLU   A 1 250 ? 4.827   -8.330  37.460  1.000 12.223 0 447  GLU   A O   1 ? 
ATOM   1968 C CB  . GLU   A 1 250 ? 3.999   -5.029  37.729  1.000 13.299 0 447  GLU   A CB  1 ? 
ATOM   1969 C CG  . GLU   A 1 250 ? 4.670   -3.795  38.298  1.000 14.137 0 447  GLU   A CG  1 ? 
ATOM   1970 C CD  . GLU   A 1 250 ? 3.842   -3.084  39.353  1.000 14.729 0 447  GLU   A CD  1 ? 
ATOM   1971 O OE1 . GLU   A 1 250 ? 3.614   -3.677  40.427  1.000 15.227 0 447  GLU   A OE1 1 ? 
ATOM   1972 O OE2 . GLU   A 1 250 ? 3.415   -1.946  39.087  1.000 16.423 0 447  GLU   A OE2 1 ? 
ATOM   1973 N N   . GLN   A 1 251 ? 3.308   -7.479  36.004  1.000 11.565 0 448  GLN   A N   1 ? 
ATOM   1974 C CA  . GLN   A 1 251 ? 2.625   -8.777  35.754  1.000 11.516 0 448  GLN   A CA  1 ? 
ATOM   1975 C C   . GLN   A 1 251 ? 3.458   -9.616  34.776  1.000 11.355 0 448  GLN   A C   1 ? 
ATOM   1976 O O   . GLN   A 1 251 ? 3.254   -10.842 34.740  1.000 11.320 0 448  GLN   A O   1 ? 
ATOM   1977 C CB  . GLN   A 1 251 ? 1.194   -8.560  35.264  1.000 11.631 0 448  GLN   A CB  1 ? 
ATOM   1978 C CG  . GLN   A 1 251 ? 0.321   -9.792  35.454  1.000 11.605 0 448  GLN   A CG  1 ? 
ATOM   1979 C CD  . GLN   A 1 251 ? -1.133  -9.559  35.127  1.000 11.892 0 448  GLN   A CD  1 ? 
ATOM   1980 O OE1 . GLN   A 1 251 ? -1.571  -8.435  34.892  1.000 12.494 0 448  GLN   A OE1 1 ? 
ATOM   1981 N NE2 . GLN   A 1 251 ? -1.895  -10.639 35.101  1.000 11.932 0 448  GLN   A NE2 1 ? 
ATOM   1982 N N   . LYS   A 1 252 ? 4.369   -8.983  34.029  1.000 11.364 0 449  LYS   A N   1 ? 
ATOM   1983 C CA  . LYS   A 1 252 ? 5.354   -9.645  33.126  1.000 11.718 0 449  LYS   A CA  1 ? 
ATOM   1984 C C   . LYS   A 1 252 ? 4.614   -10.424 32.030  1.000 11.238 0 449  LYS   A C   1 ? 
ATOM   1985 O O   . LYS   A 1 252 ? 5.046   -11.544 31.685  1.000 11.738 0 449  LYS   A O   1 ? 
ATOM   1986 C CB  . LYS   A 1 252 ? 6.313   -10.515 33.943  1.000 12.427 0 449  LYS   A CB  1 ? 
ATOM   1987 C CG  . LYS   A 1 252 ? 7.148   -9.737  34.950  1.000 13.051 0 449  LYS   A CG  1 ? 
ATOM   1988 C CD  . LYS   A 1 252 ? 8.124   -10.587 35.731  1.000 13.802 0 449  LYS   A CD  1 ? 
ATOM   1989 C CE  . LYS   A 1 252 ? 8.789   -9.827  36.858  1.000 14.264 0 449  LYS   A CE  1 ? 
ATOM   1990 N NZ  . LYS   A 1 252 ? 9.472   -8.604  36.377  1.000 14.787 0 449  LYS   A NZ  1 ? 
ATOM   1991 N N   . LEU   A 1 253 ? 3.554   -9.835  31.476  1.000 10.449 0 450  LEU   A N   1 ? 
ATOM   1992 C CA  . LEU   A 1 253 ? 2.776   -10.453 30.375  1.000 10.075 0 450  LEU   A CA  1 ? 
ATOM   1993 C C   . LEU   A 1 253 ? 3.307   -9.962  29.029  1.000 9.623  0 450  LEU   A C   1 ? 
ATOM   1994 O O   . LEU   A 1 253 ? 3.856   -8.845  28.947  1.000 9.430  0 450  LEU   A O   1 ? 
ATOM   1995 C CB  . LEU   A 1 253 ? 1.289   -10.125 30.528  1.000 10.195 0 450  LEU   A CB  1 ? 
ATOM   1996 C CG  . LEU   A 1 253 ? 0.638   -10.595 31.829  1.000 10.341 0 450  LEU   A CG  1 ? 
ATOM   1997 C CD1 . LEU   A 1 253 ? -0.867  -10.406 31.763  1.000 10.539 0 450  LEU   A CD1 1 ? 
ATOM   1998 C CD2 . LEU   A 1 253 ? 0.978   -12.047 32.131  1.000 10.397 0 450  LEU   A CD2 1 ? 
ATOM   1999 N N   . ARG   A 1 254 ? 3.132   -10.805 28.019  1.000 9.206  0 451  ARG   A N   1 ? 
ATOM   2000 C CA  . ARG   A 1 254 ? 3.447   -10.509 26.604  1.000 9.176  0 451  ARG   A CA  1 ? 
ATOM   2001 C C   . ARG   A 1 254 ? 2.222   -10.893 25.788  1.000 9.291  0 451  ARG   A C   1 ? 
ATOM   2002 O O   . ARG   A 1 254 ? 1.314   -11.543 26.304  1.000 9.388  0 451  ARG   A O   1 ? 
ATOM   2003 C CB  . ARG   A 1 254 ? 4.693   -11.291 26.182  1.000 9.005  0 451  ARG   A CB  1 ? 
ATOM   2004 C CG  . ARG   A 1 254 ? 5.949   -10.930 26.962  1.000 8.891  0 451  ARG   A CG  1 ? 
ATOM   2005 C CD  . ARG   A 1 254 ? 6.440   -9.518  26.703  1.000 8.860  0 451  ARG   A CD  1 ? 
ATOM   2006 N NE  . ARG   A 1 254 ? 7.683   -9.258  27.419  1.000 8.752  0 451  ARG   A NE  1 ? 
ATOM   2007 C CZ  . ARG   A 1 254 ? 7.782   -8.775  28.656  1.000 8.861  0 451  ARG   A CZ  1 ? 
ATOM   2008 N NH1 . ARG   A 1 254 ? 6.700   -8.462  29.353  1.000 8.923  0 451  ARG   A NH1 1 ? 
ATOM   2009 N NH2 . ARG   A 1 254 ? 8.979   -8.600  29.191  1.000 9.043  0 451  ARG   A NH2 1 ? 
ATOM   2010 N N   . PRO   A 1 255 ? 2.130   -10.504 24.499  1.000 9.539  0 452  PRO   A N   1 ? 
ATOM   2011 C CA  . PRO   A 1 255 ? 1.019   -10.964 23.666  1.000 10.046 0 452  PRO   A CA  1 ? 
ATOM   2012 C C   . PRO   A 1 255 ? 0.934   -12.499 23.661  1.000 10.870 0 452  PRO   A C   1 ? 
ATOM   2013 O O   . PRO   A 1 255 ? 1.963   -13.150 23.679  1.000 10.663 0 452  PRO   A O   1 ? 
ATOM   2014 C CB  . PRO   A 1 255 ? 1.356   -10.382 22.286  1.000 9.858  0 452  PRO   A CB  1 ? 
ATOM   2015 C CG  . PRO   A 1 255 ? 2.202   -9.164  22.605  1.000 9.638  0 452  PRO   A CG  1 ? 
ATOM   2016 C CD  . PRO   A 1 255 ? 3.044   -9.597  23.786  1.000 9.544  0 452  PRO   A CD  1 ? 
ATOM   2017 N N   . ASN   A 1 256 ? -0.286  -13.041 23.682  1.000 12.121 0 453  ASN   A N   1 ? 
ATOM   2018 C CA  . ASN   A 1 256 ? -0.529  -14.508 23.732  1.000 13.587 0 453  ASN   A CA  1 ? 
ATOM   2019 C C   . ASN   A 1 256 ? -0.169  -15.127 22.377  1.000 13.786 0 453  ASN   A C   1 ? 
ATOM   2020 O O   . ASN   A 1 256 ? -0.524  -14.539 21.345  1.000 12.933 0 453  ASN   A O   1 ? 
ATOM   2021 C CB  . ASN   A 1 256 ? -1.976  -14.853 24.100  1.000 14.728 0 453  ASN   A CB  1 ? 
ATOM   2022 C CG  . ASN   A 1 256 ? -2.203  -15.064 25.583  1.000 16.128 0 453  ASN   A CG  1 ? 
ATOM   2023 O OD1 . ASN   A 1 256 ? -1.262  -15.294 26.341  1.000 18.040 0 453  ASN   A OD1 1 ? 
ATOM   2024 N ND2 . ASN   A 1 256 ? -3.456  -15.015 26.004  1.000 17.480 0 453  ASN   A ND2 1 ? 
ATOM   2025 N N   . ILE   A 1 257 ? 0.500   -16.280 22.394  1.000 14.476 0 454  ILE   A N   1 ? 
ATOM   2026 C CA  . ILE   A 1 257 ? 0.822   -17.095 21.186  1.000 15.678 0 454  ILE   A CA  1 ? 
ATOM   2027 C C   . ILE   A 1 257 ? -0.318  -18.082 20.960  1.000 16.325 0 454  ILE   A C   1 ? 
ATOM   2028 O O   . ILE   A 1 257 ? -0.484  -19.011 21.748  1.000 17.401 0 454  ILE   A O   1 ? 
ATOM   2029 C CB  . ILE   A 1 257 ? 2.174   -17.813 21.369  1.000 15.986 0 454  ILE   A CB  1 ? 
ATOM   2030 C CG1 . ILE   A 1 257 ? 3.292   -16.832 21.730  1.000 16.439 0 454  ILE   A CG1 1 ? 
ATOM   2031 C CG2 . ILE   A 1 257 ? 2.525   -18.646 20.147  1.000 15.970 0 454  ILE   A CG2 1 ? 
ATOM   2032 C CD1 . ILE   A 1 257 ? 3.456   -15.690 20.755  1.000 16.606 0 454  ILE   A CD1 1 ? 
ATOM   2033 N N   . PRO   A 1 258 ? -1.154  -17.906 19.909  1.000 17.011 0 455  PRO   A N   1 ? 
ATOM   2034 C CA  . PRO   A 1 258 ? -2.203  -18.876 19.594  1.000 17.842 0 455  PRO   A CA  1 ? 
ATOM   2035 C C   . PRO   A 1 258 ? -1.651  -20.303 19.449  1.000 18.604 0 455  PRO   A C   1 ? 
ATOM   2036 O O   . PRO   A 1 258 ? -0.563  -20.468 18.923  1.000 18.420 0 455  PRO   A O   1 ? 
ATOM   2037 C CB  . PRO   A 1 258 ? -2.775  -18.380 18.257  1.000 17.699 0 455  PRO   A CB  1 ? 
ATOM   2038 C CG  . PRO   A 1 258 ? -2.481  -16.895 18.257  1.000 17.395 0 455  PRO   A CG  1 ? 
ATOM   2039 C CD  . PRO   A 1 258 ? -1.161  -16.759 18.988  1.000 17.117 0 455  PRO   A CD  1 ? 
ATOM   2040 N N   . ASN   A 1 259 ? -2.411  -21.293 19.927  1.000 19.915 0 456  ASN   A N   1 ? 
ATOM   2041 C CA  . ASN   A 1 259 ? -2.073  -22.740 19.838  1.000 21.030 0 456  ASN   A CA  1 ? 
ATOM   2042 C C   . ASN   A 1 259 ? -1.939  -23.137 18.361  1.000 20.724 0 456  ASN   A C   1 ? 
ATOM   2043 O O   . ASN   A 1 259 ? -1.108  -24.009 18.060  1.000 20.753 0 456  ASN   A O   1 ? 
ATOM   2044 C CB  . ASN   A 1 259 ? -3.113  -23.592 20.571  1.000 22.400 0 456  ASN   A CB  1 ? 
ATOM   2045 C CG  . ASN   A 1 259 ? -2.789  -25.071 20.566  1.000 23.660 0 456  ASN   A CG  1 ? 
ATOM   2046 O OD1 . ASN   A 1 259 ? -1.665  -25.469 20.866  1.000 25.519 0 456  ASN   A OD1 1 ? 
ATOM   2047 N ND2 . ASN   A 1 259 ? -3.773  -25.894 20.241  1.000 24.833 0 456  ASN   A ND2 1 ? 
ATOM   2048 N N   . ARG   A 1 260 ? -2.718  -22.493 17.483  1.000 20.579 0 457  ARG   A N   1 ? 
ATOM   2049 C CA  . ARG   A 1 260 ? -2.721  -22.696 16.006  1.000 20.825 0 457  ARG   A CA  1 ? 
ATOM   2050 C C   . ARG   A 1 260 ? -1.298  -22.632 15.432  1.000 20.762 0 457  ARG   A C   1 ? 
ATOM   2051 O O   . ARG   A 1 260 ? -1.016  -23.388 14.482  1.000 21.226 0 457  ARG   A O   1 ? 
ATOM   2052 C CB  . ARG   A 1 260 ? -3.595  -21.627 15.341  1.000 20.928 0 457  ARG   A CB  1 ? 
ATOM   2053 C CG  . ARG   A 1 260 ? -3.543  -21.636 13.820  1.000 20.878 0 457  ARG   A CG  1 ? 
ATOM   2054 C CD  . ARG   A 1 260 ? -4.551  -20.688 13.208  1.000 20.658 0 457  ARG   A CD  1 ? 
ATOM   2055 N NE  . ARG   A 1 260 ? -4.061  -19.317 13.118  1.000 20.105 0 457  ARG   A NE  1 ? 
ATOM   2056 C CZ  . ARG   A 1 260 ? -3.325  -18.827 12.121  1.000 19.574 0 457  ARG   A CZ  1 ? 
ATOM   2057 N NH1 . ARG   A 1 260 ? -2.964  -19.594 11.104  1.000 19.443 0 457  ARG   A NH1 1 ? 
ATOM   2058 N NH2 . ARG   A 1 260 ? -2.955  -17.557 12.141  1.000 19.229 0 457  ARG   A NH2 1 ? 
ATOM   2059 N N   . TRP   A 1 261 ? -0.442  -21.757 15.970  1.000 20.724 0 458  TRP   A N   1 ? 
ATOM   2060 C CA  . TRP   A 1 261 ? 0.897   -21.430 15.406  1.000 20.815 0 458  TRP   A CA  1 ? 
ATOM   2061 C C   . TRP   A 1 261 ? 1.872   -22.607 15.564  1.000 22.206 0 458  TRP   A C   1 ? 
ATOM   2062 O O   . TRP   A 1 261 ? 2.960   -22.547 14.956  1.000 22.423 0 458  TRP   A O   1 ? 
ATOM   2063 C CB  . TRP   A 1 261 ? 1.443   -20.148 16.047  1.000 19.488 0 458  TRP   A CB  1 ? 
ATOM   2064 C CG  . TRP   A 1 261 ? 0.645   -18.921 15.725  1.000 18.481 0 458  TRP   A CG  1 ? 
ATOM   2065 C CD1 . TRP   A 1 261 ? -0.533  -18.854 15.037  1.000 17.952 0 458  TRP   A CD1 1 ? 
ATOM   2066 C CD2 . TRP   A 1 261 ? 0.956   -17.571 16.114  1.000 17.669 0 458  TRP   A CD2 1 ? 
ATOM   2067 N NE1 . TRP   A 1 261 ? -0.968  -17.558 14.961  1.000 17.483 0 458  TRP   A NE1 1 ? 
ATOM   2068 C CE2 . TRP   A 1 261 ? -0.076  -16.748 15.613  1.000 17.486 0 458  TRP   A CE2 1 ? 
ATOM   2069 C CE3 . TRP   A 1 261 ? 2.000   -16.978 16.833  1.000 17.476 0 458  TRP   A CE3 1 ? 
ATOM   2070 C CZ2 . TRP   A 1 261 ? -0.090  -15.368 15.811  1.000 17.443 0 458  TRP   A CZ2 1 ? 
ATOM   2071 C CZ3 . TRP   A 1 261 ? 1.985   -15.614 17.028  1.000 17.549 0 458  TRP   A CZ3 1 ? 
ATOM   2072 C CH2 . TRP   A 1 261 ? 0.953   -14.822 16.523  1.000 17.473 0 458  TRP   A CH2 1 ? 
ATOM   2073 N N   . GLN   A 1 262 ? 1.503   -23.637 16.336  1.000 24.148 0 459  GLN   A N   1 ? 
ATOM   2074 C CA  . GLN   A 1 262 ? 2.320   -24.868 16.526  1.000 25.385 0 459  GLN   A CA  1 ? 
ATOM   2075 C C   . GLN   A 1 262 ? 2.058   -25.870 15.392  1.000 25.782 0 459  GLN   A C   1 ? 
ATOM   2076 O O   . GLN   A 1 262 ? 2.845   -26.826 15.274  1.000 26.392 0 459  GLN   A O   1 ? 
ATOM   2077 C CB  . GLN   A 1 262 ? 2.037   -25.495 17.894  1.000 26.410 0 459  GLN   A CB  1 ? 
ATOM   2078 C CG  . GLN   A 1 262 ? 2.635   -24.710 19.054  1.000 27.140 0 459  GLN   A CG  1 ? 
ATOM   2079 C CD  . GLN   A 1 262 ? 4.128   -24.525 18.916  1.000 28.010 0 459  GLN   A CD  1 ? 
ATOM   2080 O OE1 . GLN   A 1 262 ? 4.853   -25.436 18.520  1.000 28.970 0 459  GLN   A OE1 1 ? 
ATOM   2081 N NE2 . GLN   A 1 262 ? 4.604   -23.331 19.233  1.000 28.614 0 459  GLN   A NE2 1 ? 
ATOM   2082 N N   . SER   A 1 263 ? 1.017   -25.656 14.580  1.000 26.015 0 460  SER   A N   1 ? 
ATOM   2083 C CA  . SER   A 1 263 ? 0.590   -26.572 13.486  1.000 26.312 0 460  SER   A CA  1 ? 
ATOM   2084 C C   . SER   A 1 263 ? 1.434   -26.357 12.221  1.000 25.937 0 460  SER   A C   1 ? 
ATOM   2085 O O   . SER   A 1 263 ? 1.327   -27.189 11.300  1.000 25.800 0 460  SER   A O   1 ? 
ATOM   2086 C CB  . SER   A 1 263 ? -0.880  -26.406 13.188  1.000 26.959 0 460  SER   A CB  1 ? 
ATOM   2087 O OG  . SER   A 1 263 ? -1.130  -25.179 12.516  1.000 27.630 0 460  SER   A OG  1 ? 
ATOM   2088 N N   . CYS   A 1 264 ? 2.241   -25.291 12.177  1.000 25.673 0 461  CYS   A N   1 ? 
ATOM   2089 C CA  . CYS   A 1 264 ? 2.960   -24.812 10.966  1.000 25.275 0 461  CYS   A CA  1 ? 
ATOM   2090 C C   . CYS   A 1 264 ? 4.401   -24.430 11.331  1.000 23.577 0 461  CYS   A C   1 ? 
ATOM   2091 O O   . CYS   A 1 264 ? 4.570   -23.631 12.271  1.000 23.185 0 461  CYS   A O   1 ? 
ATOM   2092 C CB  . CYS   A 1 264 ? 2.218   -23.620 10.373  1.000 26.055 0 461  CYS   A CB  1 ? 
ATOM   2093 S SG  . CYS   A 1 264 ? 2.675   -23.254 8.661   1.000 28.776 0 461  CYS   A SG  1 ? 
ATOM   2094 N N   . GLU   A 1 265 ? 5.391   -24.972 10.612  1.000 22.284 0 462  GLU   A N   1 ? 
ATOM   2095 C CA  . GLU   A 1 265 ? 6.843   -24.773 10.885  1.000 21.477 0 462  GLU   A CA  1 ? 
ATOM   2096 C C   . GLU   A 1 265 ? 7.192   -23.280 10.814  1.000 19.555 0 462  GLU   A C   1 ? 
ATOM   2097 O O   . GLU   A 1 265 ? 7.964   -22.818 11.676  1.000 19.064 0 462  GLU   A O   1 ? 
ATOM   2098 C CB  . GLU   A 1 265 ? 7.694   -25.585 9.905   1.000 22.648 0 462  GLU   A CB  1 ? 
ATOM   2099 C CG  . GLU   A 1 265 ? 9.195   -25.399 10.078  1.000 23.716 0 462  GLU   A CG  1 ? 
ATOM   2100 C CD  . GLU   A 1 265 ? 9.768   -25.791 11.431  1.000 24.852 0 462  GLU   A CD  1 ? 
ATOM   2101 O OE1 . GLU   A 1 265 ? 9.097   -26.540 12.174  1.000 26.001 0 462  GLU   A OE1 1 ? 
ATOM   2102 O OE2 . GLU   A 1 265 ? 10.897  -25.354 11.739  1.000 26.710 0 462  GLU   A OE2 1 ? 
ATOM   2103 N N   . ALA   A 1 266 ? 6.657   -22.557 9.826   1.000 17.719 0 463  ALA   A N   1 ? 
ATOM   2104 C CA  . ALA   A 1 266 ? 6.871   -21.101 9.643   1.000 16.636 0 463  ALA   A CA  1 ? 
ATOM   2105 C C   . ALA   A 1 266 ? 6.366   -20.340 10.875  1.000 15.634 0 463  ALA   A C   1 ? 
ATOM   2106 O O   . ALA   A 1 266 ? 7.112   -19.487 11.391  1.000 14.818 0 463  ALA   A O   1 ? 
ATOM   2107 C CB  . ALA   A 1 266 ? 6.191   -20.624 8.384   1.000 16.731 0 463  ALA   A CB  1 ? 
ATOM   2108 N N   . LEU   A 1 267 ? 5.152   -20.640 11.343  1.000 15.018 0 464  LEU   A N   1 ? 
ATOM   2109 C CA  . LEU   A 1 267 ? 4.548   -19.965 12.523  1.000 14.963 0 464  LEU   A CA  1 ? 
ATOM   2110 C C   . LEU   A 1 267 ? 5.288   -20.380 13.803  1.000 14.568 0 464  LEU   A C   1 ? 
ATOM   2111 O O   . LEU   A 1 267 ? 5.421   -19.522 14.699  1.000 14.069 0 464  LEU   A O   1 ? 
ATOM   2112 C CB  . LEU   A 1 267 ? 3.049   -20.275 12.597  1.000 15.015 0 464  LEU   A CB  1 ? 
ATOM   2113 C CG  . LEU   A 1 267 ? 2.172   -19.499 11.614  1.000 15.249 0 464  LEU   A CG  1 ? 
ATOM   2114 C CD1 . LEU   A 1 267 ? 0.759   -20.058 11.590  1.000 15.361 0 464  LEU   A CD1 1 ? 
ATOM   2115 C CD2 . LEU   A 1 267 ? 2.142   -18.015 11.952  1.000 15.384 0 464  LEU   A CD2 1 ? 
ATOM   2116 N N   . ARG   A 1 268 ? 5.765   -21.628 13.891  1.000 14.498 0 465  ARG   A N   1 ? 
ATOM   2117 C CA  A ARG   A 1 268 ? 6.556   -22.115 15.055  0.500 14.586 0 465  ARG   A CA  1 ? 
ATOM   2118 C CA  B ARG   A 1 268 ? 6.558   -22.115 15.054  0.500 14.474 0 465  ARG   A CA  1 ? 
ATOM   2119 C C   . ARG   A 1 268 ? 7.843   -21.288 15.161  1.000 14.160 0 465  ARG   A C   1 ? 
ATOM   2120 O O   . ARG   A 1 268 ? 8.173   -20.859 16.275  1.000 13.978 0 465  ARG   A O   1 ? 
ATOM   2121 C CB  A ARG   A 1 268 ? 6.879   -23.607 14.920  0.500 15.041 0 465  ARG   A CB  1 ? 
ATOM   2122 C CB  B ARG   A 1 268 ? 6.889   -23.607 14.925  0.500 14.774 0 465  ARG   A CB  1 ? 
ATOM   2123 C CG  A ARG   A 1 268 ? 7.439   -24.239 16.187  0.500 15.575 0 465  ARG   A CG  1 ? 
ATOM   2124 C CG  B ARG   A 1 268 ? 5.749   -24.532 15.324  0.500 15.127 0 465  ARG   A CG  1 ? 
ATOM   2125 C CD  A ARG   A 1 268 ? 7.949   -25.653 15.973  0.500 16.021 0 465  ARG   A CD  1 ? 
ATOM   2126 C CD  B ARG   A 1 268 ? 6.204   -25.955 15.600  0.500 15.433 0 465  ARG   A CD  1 ? 
ATOM   2127 N NE  A ARG   A 1 268 ? 9.136   -25.689 15.130  0.500 16.354 0 465  ARG   A NE  1 ? 
ATOM   2128 N NE  B ARG   A 1 268 ? 6.835   -26.595 14.454  0.500 15.759 0 465  ARG   A NE  1 ? 
ATOM   2129 C CZ  A ARG   A 1 268 ? 10.331  -25.238 15.495  0.500 16.552 0 465  ARG   A CZ  1 ? 
ATOM   2130 C CZ  B ARG   A 1 268 ? 6.192   -27.316 13.542  0.500 15.908 0 465  ARG   A CZ  1 ? 
ATOM   2131 N NH1 A ARG   A 1 268 ? 10.499  -24.704 16.693  0.500 16.776 0 465  ARG   A NH1 1 ? 
ATOM   2132 N NH1 B ARG   A 1 268 ? 6.858   -27.864 12.541  0.500 15.991 0 465  ARG   A NH1 1 ? 
ATOM   2133 N NH2 A ARG   A 1 268 ? 11.352  -25.315 14.661  0.500 16.673 0 465  ARG   A NH2 1 ? 
ATOM   2134 N NH2 B ARG   A 1 268 ? 4.886   -27.486 13.632  0.500 16.105 0 465  ARG   A NH2 1 ? 
ATOM   2135 N N   . VAL   A 1 269 ? 8.529   -21.082 14.037  1.000 13.667 0 466  VAL   A N   1 ? 
ATOM   2136 C CA  . VAL   A 1 269 ? 9.798   -20.297 13.986  1.000 13.279 0 466  VAL   A CA  1 ? 
ATOM   2137 C C   . VAL   A 1 269 ? 9.494   -18.831 14.320  1.000 12.614 0 466  VAL   A C   1 ? 
ATOM   2138 O O   . VAL   A 1 269 ? 10.269  -18.237 15.089  1.000 12.478 0 466  VAL   A O   1 ? 
ATOM   2139 C CB  . VAL   A 1 269 ? 10.512  -20.457 12.630  1.000 13.549 0 466  VAL   A CB  1 ? 
ATOM   2140 C CG1 . VAL   A 1 269 ? 11.613  -19.425 12.433  1.000 13.753 0 466  VAL   A CG1 1 ? 
ATOM   2141 C CG2 . VAL   A 1 269 ? 11.070  -21.864 12.471  1.000 13.886 0 466  VAL   A CG2 1 ? 
ATOM   2142 N N   . MET   A 1 270 ? 8.404   -18.274 13.786  1.000 12.016 0 467  MET   A N   1 ? 
ATOM   2143 C CA  . MET   A 1 270 ? 7.986   -16.873 14.068  1.000 11.853 0 467  MET   A CA  1 ? 
ATOM   2144 C C   . MET   A 1 270 ? 7.715   -16.716 15.571  1.000 11.475 0 467  MET   A C   1 ? 
ATOM   2145 O O   . MET   A 1 270 ? 8.194   -15.733 16.160  1.000 10.817 0 467  MET   A O   1 ? 
ATOM   2146 C CB  . MET   A 1 270 ? 6.737   -16.497 13.263  1.000 12.158 0 467  MET   A CB  1 ? 
ATOM   2147 C CG  . MET   A 1 270 ? 7.025   -16.206 11.800  1.000 12.503 0 467  MET   A CG  1 ? 
ATOM   2148 S SD  . MET   A 1 270 ? 7.921   -14.646 11.548  1.000 13.139 0 467  MET   A SD  1 ? 
ATOM   2149 C CE  . MET   A 1 270 ? 6.613   -13.454 11.835  1.000 13.056 0 467  MET   A CE  1 ? 
ATOM   2150 N N   . ALA   A 1 271 ? 6.993   -17.662 16.176  1.000 11.388 0 468  ALA   A N   1 ? 
ATOM   2151 C CA  . ALA   A 1 271 ? 6.631   -17.649 17.614  1.000 11.375 0 468  ALA   A CA  1 ? 
ATOM   2152 C C   . ALA   A 1 271 ? 7.903   -17.690 18.473  1.000 11.328 0 468  ALA   A C   1 ? 
ATOM   2153 O O   . ALA   A 1 271 ? 7.972   -16.959 19.477  1.000 10.967 0 468  ALA   A O   1 ? 
ATOM   2154 C CB  . ALA   A 1 271 ? 5.712   -18.803 17.934  1.000 11.398 0 468  ALA   A CB  1 ? 
ATOM   2155 N N   . LYS   A 1 272 ? 8.880   -18.512 18.089  1.000 11.560 0 469  LYS   A N   1 ? 
ATOM   2156 C CA  . LYS   A 1 272 ? 10.168  -18.655 18.818  1.000 12.243 0 469  LYS   A CA  1 ? 
ATOM   2157 C C   . LYS   A 1 272 ? 10.940  -17.330 18.747  1.000 11.585 0 469  LYS   A C   1 ? 
ATOM   2158 O O   . LYS   A 1 272 ? 11.491  -16.902 19.772  1.000 11.370 0 469  LYS   A O   1 ? 
ATOM   2159 C CB  . LYS   A 1 272 ? 10.969  -19.824 18.241  1.000 13.391 0 469  LYS   A CB  1 ? 
ATOM   2160 C CG  . LYS   A 1 272 ? 12.312  -20.082 18.909  1.000 14.523 0 469  LYS   A CG  1 ? 
ATOM   2161 C CD  . LYS   A 1 272 ? 13.020  -21.308 18.374  1.000 15.748 0 469  LYS   A CD  1 ? 
ATOM   2162 C CE  . LYS   A 1 272 ? 14.498  -21.333 18.704  1.000 16.899 0 469  LYS   A CE  1 ? 
ATOM   2163 N NZ  . LYS   A 1 272 ? 14.737  -21.426 20.161  1.000 17.773 0 469  LYS   A NZ  1 ? 
ATOM   2164 N N   . ILE   A 1 273 ? 10.973  -16.685 17.580  1.000 11.252 0 470  ILE   A N   1 ? 
ATOM   2165 C CA  . ILE   A 1 273 ? 11.627  -15.353 17.416  1.000 10.863 0 470  ILE   A CA  1 ? 
ATOM   2166 C C   . ILE   A 1 273 ? 10.953  -14.356 18.370  1.000 10.730 0 470  ILE   A C   1 ? 
ATOM   2167 O O   . ILE   A 1 273 ? 11.673  -13.643 19.084  1.000 10.368 0 470  ILE   A O   1 ? 
ATOM   2168 C CB  . ILE   A 1 273 ? 11.589  -14.888 15.947  1.000 10.771 0 470  ILE   A CB  1 ? 
ATOM   2169 C CG1 . ILE   A 1 273 ? 12.529  -15.731 15.080  1.000 10.909 0 470  ILE   A CG1 1 ? 
ATOM   2170 C CG2 . ILE   A 1 273 ? 11.901  -13.400 15.836  1.000 10.730 0 470  ILE   A CG2 1 ? 
ATOM   2171 C CD1 . ILE   A 1 273 ? 12.302  -15.581 13.595  1.000 11.077 0 470  ILE   A CD1 1 ? 
ATOM   2172 N N   . MET   A 1 274 ? 9.620   -14.320 18.400  1.000 10.513 0 471  MET   A N   1 ? 
ATOM   2173 C CA  . MET   A 1 274 ? 8.866   -13.368 19.257  1.000 10.884 0 471  MET   A CA  1 ? 
ATOM   2174 C C   . MET   A 1 274 ? 9.300   -13.534 20.716  1.000 11.338 0 471  MET   A C   1 ? 
ATOM   2175 O O   . MET   A 1 274 ? 9.638   -12.523 21.349  1.000 10.963 0 471  MET   A O   1 ? 
ATOM   2176 C CB  . MET   A 1 274 ? 7.358   -13.590 19.162  1.000 10.782 0 471  MET   A CB  1 ? 
ATOM   2177 C CG  . MET   A 1 274 ? 6.783   -13.168 17.842  1.000 10.677 0 471  MET   A CG  1 ? 
ATOM   2178 S SD  . MET   A 1 274 ? 5.112   -13.809 17.684  1.000 10.643 0 471  MET   A SD  1 ? 
ATOM   2179 C CE  . MET   A 1 274 ? 5.032   -14.064 15.912  1.000 11.067 0 471  MET   A CE  1 ? 
ATOM   2180 N N   . ARG   A 1 275 ? 9.282   -14.759 21.246  1.000 12.040 0 472  ARG   A N   1 ? 
ATOM   2181 C CA  A ARG   A 1 275 ? 9.617   -14.972 22.680  0.500 12.678 0 472  ARG   A CA  1 ? 
ATOM   2182 C CA  B ARG   A 1 275 ? 9.648   -15.042 22.661  0.500 12.450 0 472  ARG   A CA  1 ? 
ATOM   2183 C C   . ARG   A 1 275 ? 11.065  -14.524 22.928  1.000 12.394 0 472  ARG   A C   1 ? 
ATOM   2184 O O   . ARG   A 1 275 ? 11.305  -13.951 24.005  1.000 12.600 0 472  ARG   A O   1 ? 
ATOM   2185 C CB  A ARG   A 1 275 ? 9.307   -16.401 23.147  0.500 13.470 0 472  ARG   A CB  1 ? 
ATOM   2186 C CB  B ARG   A 1 275 ? 9.545   -16.544 22.948  0.500 12.869 0 472  ARG   A CB  1 ? 
ATOM   2187 C CG  A ARG   A 1 275 ? 10.031  -17.529 22.426  0.500 14.225 0 472  ARG   A CG  1 ? 
ATOM   2188 C CG  B ARG   A 1 275 ? 8.117   -17.072 22.974  0.500 13.350 0 472  ARG   A CG  1 ? 
ATOM   2189 C CD  A ARG   A 1 275 ? 9.684   -18.857 23.085  0.500 14.803 0 472  ARG   A CD  1 ? 
ATOM   2190 C CD  B ARG   A 1 275 ? 8.025   -18.497 23.487  0.500 13.875 0 472  ARG   A CD  1 ? 
ATOM   2191 N NE  A ARG   A 1 275 ? 10.220  -20.033 22.412  0.500 15.386 0 472  ARG   A NE  1 ? 
ATOM   2192 N NE  B ARG   A 1 275 ? 6.679   -19.038 23.356  0.500 14.471 0 472  ARG   A NE  1 ? 
ATOM   2193 C CZ  A ARG   A 1 275 ? 9.538   -20.793 21.561  0.500 15.683 0 472  ARG   A CZ  1 ? 
ATOM   2194 C CZ  B ARG   A 1 275 ? 6.244   -19.725 22.305  0.500 14.692 0 472  ARG   A CZ  1 ? 
ATOM   2195 N NH1 A ARG   A 1 275 ? 8.285   -20.495 21.262  0.500 15.793 0 472  ARG   A NH1 1 ? 
ATOM   2196 N NH1 B ARG   A 1 275 ? 7.052   -19.957 21.285  0.500 15.028 0 472  ARG   A NH1 1 ? 
ATOM   2197 N NH2 A ARG   A 1 275 ? 10.114  -21.841 21.001  0.500 16.076 0 472  ARG   A NH2 1 ? 
ATOM   2198 N NH2 B ARG   A 1 275 ? 5.003   -20.173 22.275  0.500 14.954 0 472  ARG   A NH2 1 ? 
ATOM   2199 N N   . GLU   A 1 276 ? 11.965  -14.707 21.958  1.000 12.079 0 473  GLU   A N   1 ? 
ATOM   2200 C CA  . GLU   A 1 276 ? 13.399  -14.339 22.106  1.000 12.029 0 473  GLU   A CA  1 ? 
ATOM   2201 C C   . GLU   A 1 276 ? 13.621  -12.849 21.806  1.000 11.355 0 473  GLU   A C   1 ? 
ATOM   2202 O O   . GLU   A 1 276 ? 14.765  -12.403 21.949  1.000 11.503 0 473  GLU   A O   1 ? 
ATOM   2203 C CB  . GLU   A 1 276 ? 14.256  -15.263 21.242  1.000 12.769 0 473  GLU   A CB  1 ? 
ATOM   2204 C CG  . GLU   A 1 276 ? 14.206  -16.701 21.728  1.000 13.688 0 473  GLU   A CG  1 ? 
ATOM   2205 C CD  . GLU   A 1 276 ? 14.898  -17.741 20.865  1.000 14.833 0 473  GLU   A CD  1 ? 
ATOM   2206 O OE1 . GLU   A 1 276 ? 15.454  -17.376 19.810  1.000 15.906 0 473  GLU   A OE1 1 ? 
ATOM   2207 O OE2 . GLU   A 1 276 ? 14.870  -18.926 21.259  1.000 16.500 0 473  GLU   A OE2 1 ? 
ATOM   2208 N N   . CYS   A 1 277 ? 12.573  -12.107 21.429  1.000 10.497 0 474  CYS   A N   1 ? 
ATOM   2209 C CA  . CYS   A 1 277 ? 12.571  -10.619 21.348  1.000 10.238 0 474  CYS   A CA  1 ? 
ATOM   2210 C C   . CYS   A 1 277 ? 12.001  -10.013 22.638  1.000 9.898  0 474  CYS   A C   1 ? 
ATOM   2211 O O   . CYS   A 1 277 ? 12.181  -8.813  22.849  1.000 10.162 0 474  CYS   A O   1 ? 
ATOM   2212 C CB  . CYS   A 1 277 ? 11.719  -10.122 20.184  1.000 9.983  0 474  CYS   A CB  1 ? 
ATOM   2213 S SG  . CYS   A 1 277 ? 12.411  -10.479 18.548  1.000 10.190 0 474  CYS   A SG  1 ? 
ATOM   2214 N N   . TRP   A 1 278 ? 11.309  -10.803 23.464  1.000 9.920  0 475  TRP   A N   1 ? 
ATOM   2215 C CA  . TRP   A 1 278 ? 10.391  -10.273 24.507  1.000 9.989  0 475  TRP   A CA  1 ? 
ATOM   2216 C C   . TRP   A 1 278 ? 10.970  -10.398 25.918  1.000 10.331 0 475  TRP   A C   1 ? 
ATOM   2217 O O   . TRP   A 1 278 ? 10.287  -9.963  26.859  1.000 10.420 0 475  TRP   A O   1 ? 
ATOM   2218 C CB  . TRP   A 1 278 ? 9.026   -10.952 24.393  1.000 9.768  0 475  TRP   A CB  1 ? 
ATOM   2219 C CG  . TRP   A 1 278 ? 8.236   -10.491 23.210  1.000 9.360  0 475  TRP   A CG  1 ? 
ATOM   2220 C CD1 . TRP   A 1 278 ? 8.469   -9.396  22.426  1.000 9.339  0 475  TRP   A CD1 1 ? 
ATOM   2221 C CD2 . TRP   A 1 278 ? 7.053   -11.114 22.688  1.000 9.276  0 475  TRP   A CD2 1 ? 
ATOM   2222 N NE1 . TRP   A 1 278 ? 7.520   -9.308  21.444  1.000 9.223  0 475  TRP   A NE1 1 ? 
ATOM   2223 C CE2 . TRP   A 1 278 ? 6.632   -10.342 21.585  1.000 9.176  0 475  TRP   A CE2 1 ? 
ATOM   2224 C CE3 . TRP   A 1 278 ? 6.309   -12.243 23.047  1.000 9.272  0 475  TRP   A CE3 1 ? 
ATOM   2225 C CZ2 . TRP   A 1 278 ? 5.501   -10.671 20.840  1.000 9.243  0 475  TRP   A CZ2 1 ? 
ATOM   2226 C CZ3 . TRP   A 1 278 ? 5.193   -12.567 22.310  1.000 9.215  0 475  TRP   A CZ3 1 ? 
ATOM   2227 C CH2 . TRP   A 1 278 ? 4.799   -11.791 21.221  1.000 9.114  0 475  TRP   A CH2 1 ? 
ATOM   2228 N N   . TYR   A 1 279 ? 12.184  -10.925 26.071  1.000 10.963 0 476  TYR   A N   1 ? 
ATOM   2229 C CA  . TYR   A 1 279 ? 12.867  -10.985 27.388  1.000 11.527 0 476  TYR   A CA  1 ? 
ATOM   2230 C C   . TYR   A 1 279 ? 12.887  -9.582  27.998  1.000 11.650 0 476  TYR   A C   1 ? 
ATOM   2231 O O   . TYR   A 1 279 ? 13.121  -8.605  27.260  1.000 11.149 0 476  TYR   A O   1 ? 
ATOM   2232 C CB  . TYR   A 1 279 ? 14.297  -11.509 27.255  1.000 12.152 0 476  TYR   A CB  1 ? 
ATOM   2233 C CG  . TYR   A 1 279 ? 14.412  -12.918 26.735  1.000 12.890 0 476  TYR   A CG  1 ? 
ATOM   2234 C CD1 . TYR   A 1 279 ? 13.785  -13.974 27.378  1.000 13.391 0 476  TYR   A CD1 1 ? 
ATOM   2235 C CD2 . TYR   A 1 279 ? 15.161  -13.199 25.605  1.000 13.260 0 476  TYR   A CD2 1 ? 
ATOM   2236 C CE1 . TYR   A 1 279 ? 13.895  -15.271 26.905  1.000 14.029 0 476  TYR   A CE1 1 ? 
ATOM   2237 C CE2 . TYR   A 1 279 ? 15.282  -14.490 25.121  1.000 13.844 0 476  TYR   A CE2 1 ? 
ATOM   2238 C CZ  . TYR   A 1 279 ? 14.647  -15.531 25.774  1.000 14.085 0 476  TYR   A CZ  1 ? 
ATOM   2239 O OH  . TYR   A 1 279 ? 14.765  -16.804 25.298  1.000 15.847 0 476  TYR   A OH  1 ? 
ATOM   2240 N N   . ALA   A 1 280 ? 12.650  -9.488  29.305  1.000 12.197 0 477  ALA   A N   1 ? 
ATOM   2241 C CA  . ALA   A 1 280 ? 12.729  -8.231  30.084  1.000 12.659 0 477  ALA   A CA  1 ? 
ATOM   2242 C C   . ALA   A 1 280 ? 14.124  -7.614  29.925  1.000 13.302 0 477  ALA   A C   1 ? 
ATOM   2243 O O   . ALA   A 1 280 ? 14.204  -6.384  29.749  1.000 13.962 0 477  ALA   A O   1 ? 
ATOM   2244 C CB  . ALA   A 1 280 ? 12.407  -8.500  31.535  1.000 12.626 0 477  ALA   A CB  1 ? 
ATOM   2245 N N   . ASN   A 1 281 ? 15.175  -8.442  29.972  1.000 13.863 0 478  ASN   A N   1 ? 
ATOM   2246 C CA  . ASN   A 1 281 ? 16.590  -8.003  29.841  1.000 14.389 0 478  ASN   A CA  1 ? 
ATOM   2247 C C   . ASN   A 1 281 ? 16.951  -7.923  28.353  1.000 13.760 0 478  ASN   A C   1 ? 
ATOM   2248 O O   . ASN   A 1 281 ? 16.979  -8.974  27.692  1.000 13.726 0 478  ASN   A O   1 ? 
ATOM   2249 C CB  . ASN   A 1 281 ? 17.549  -8.928  30.598  1.000 15.344 0 478  ASN   A CB  1 ? 
ATOM   2250 C CG  . ASN   A 1 281 ? 18.979  -8.426  30.614  1.000 16.242 0 478  ASN   A CG  1 ? 
ATOM   2251 O OD1 . ASN   A 1 281 ? 19.322  -7.468  29.924  1.000 17.516 0 478  ASN   A OD1 1 ? 
ATOM   2252 N ND2 . ASN   A 1 281 ? 19.827  -9.064  31.403  1.000 17.585 0 478  ASN   A ND2 1 ? 
ATOM   2253 N N   . GLY   A 1 282 ? 17.225  -6.713  27.859  1.000 13.583 0 479  GLY   A N   1 ? 
ATOM   2254 C CA  . GLY   A 1 282 ? 17.605  -6.452  26.457  1.000 13.283 0 479  GLY   A CA  1 ? 
ATOM   2255 C C   . GLY   A 1 282 ? 18.792  -7.292  26.004  1.000 13.095 0 479  GLY   A C   1 ? 
ATOM   2256 O O   . GLY   A 1 282 ? 18.806  -7.707  24.832  1.000 12.672 0 479  GLY   A O   1 ? 
ATOM   2257 N N   . ALA   A 1 283 ? 19.750  -7.559  26.899  1.000 13.395 0 480  ALA   A N   1 ? 
ATOM   2258 C CA  . ALA   A 1 283 ? 20.996  -8.305  26.600  1.000 13.552 0 480  ALA   A CA  1 ? 
ATOM   2259 C C   . ALA   A 1 283 ? 20.687  -9.755  26.200  1.000 13.349 0 480  ALA   A C   1 ? 
ATOM   2260 O O   . ALA   A 1 283 ? 21.543  -10.373 25.547  1.000 14.235 0 480  ALA   A O   1 ? 
ATOM   2261 C CB  . ALA   A 1 283 ? 21.927  -8.253  27.787  1.000 13.872 0 480  ALA   A CB  1 ? 
ATOM   2262 N N   . ALA   A 1 284 ? 19.517  -10.283 26.577  1.000 12.867 0 481  ALA   A N   1 ? 
ATOM   2263 C CA  . ALA   A 1 284 ? 19.088  -11.672 26.280  1.000 12.446 0 481  ALA   A CA  1 ? 
ATOM   2264 C C   . ALA   A 1 284 ? 18.436  -11.769 24.893  1.000 12.110 0 481  ALA   A C   1 ? 
ATOM   2265 O O   . ALA   A 1 284 ? 18.303  -12.896 24.389  1.000 12.234 0 481  ALA   A O   1 ? 
ATOM   2266 C CB  . ALA   A 1 284 ? 18.146  -12.161 27.354  1.000 12.499 0 481  ALA   A CB  1 ? 
ATOM   2267 N N   . ARG   A 1 285 ? 18.024  -10.645 24.299  1.000 11.795 0 482  ARG   A N   1 ? 
ATOM   2268 C CA  . ARG   A 1 285 ? 17.220  -10.632 23.045  1.000 11.524 0 482  ARG   A CA  1 ? 
ATOM   2269 C C   . ARG   A 1 285 ? 18.088  -10.991 21.835  1.000 11.601 0 482  ARG   A C   1 ? 
ATOM   2270 O O   . ARG   A 1 285 ? 19.306  -10.717 21.856  1.000 11.636 0 482  ARG   A O   1 ? 
ATOM   2271 C CB  . ARG   A 1 285 ? 16.564  -9.266  22.834  1.000 11.092 0 482  ARG   A CB  1 ? 
ATOM   2272 C CG  . ARG   A 1 285 ? 15.514  -8.941  23.882  1.000 10.820 0 482  ARG   A CG  1 ? 
ATOM   2273 C CD  . ARG   A 1 285 ? 14.941  -7.544  23.746  1.000 10.549 0 482  ARG   A CD  1 ? 
ATOM   2274 N NE  . ARG   A 1 285 ? 14.272  -7.191  24.991  1.000 10.389 0 482  ARG   A NE  1 ? 
ATOM   2275 C CZ  . ARG   A 1 285 ? 14.212  -5.976  25.525  1.000 10.268 0 482  ARG   A CZ  1 ? 
ATOM   2276 N NH1 . ARG   A 1 285 ? 14.738  -4.935  24.900  1.000 10.291 0 482  ARG   A NH1 1 ? 
ATOM   2277 N NH2 . ARG   A 1 285 ? 13.620  -5.806  26.694  1.000 10.515 0 482  ARG   A NH2 1 ? 
ATOM   2278 N N   . LEU   A 1 286 ? 17.463  -11.553 20.799  1.000 11.911 0 483  LEU   A N   1 ? 
ATOM   2279 C CA  . LEU   A 1 286 ? 18.095  -11.775 19.472  1.000 12.202 0 483  LEU   A CA  1 ? 
ATOM   2280 C C   . LEU   A 1 286 ? 18.588  -10.436 18.916  1.000 12.265 0 483  LEU   A C   1 ? 
ATOM   2281 O O   . LEU   A 1 286 ? 18.051  -9.384  19.319  1.000 12.161 0 483  LEU   A O   1 ? 
ATOM   2282 C CB  . LEU   A 1 286 ? 17.070  -12.384 18.513  1.000 12.734 0 483  LEU   A CB  1 ? 
ATOM   2283 C CG  . LEU   A 1 286 ? 16.628  -13.811 18.821  1.000 13.052 0 483  LEU   A CG  1 ? 
ATOM   2284 C CD1 . LEU   A 1 286 ? 15.434  -14.198 17.965  1.000 13.301 0 483  LEU   A CD1 1 ? 
ATOM   2285 C CD2 . LEU   A 1 286 ? 17.770  -14.794 18.613  1.000 13.388 0 483  LEU   A CD2 1 ? 
ATOM   2286 N N   . THR   A 1 287 ? 19.560  -10.476 18.005  1.000 12.047 0 484  THR   A N   1 ? 
ATOM   2287 C CA  . THR   A 1 287 ? 19.942  -9.313  17.164  1.000 12.111 0 484  THR   A CA  1 ? 
ATOM   2288 C C   . THR   A 1 287 ? 19.083  -9.322  15.895  1.000 11.903 0 484  THR   A C   1 ? 
ATOM   2289 O O   . THR   A 1 287 ? 18.586  -10.400 15.511  1.000 11.798 0 484  THR   A O   1 ? 
ATOM   2290 C CB  . THR   A 1 287 ? 21.432  -9.329  16.809  1.000 12.384 0 484  THR   A CB  1 ? 
ATOM   2291 O OG1 . THR   A 1 287 ? 21.648  -10.475 15.986  1.000 12.580 0 484  THR   A OG1 1 ? 
ATOM   2292 C CG2 . THR   A 1 287 ? 22.331  -9.345  18.026  1.000 12.594 0 484  THR   A CG2 1 ? 
ATOM   2293 N N   . ALA   A 1 288 ? 18.934  -8.163  15.252  1.000 11.857 0 485  ALA   A N   1 ? 
ATOM   2294 C CA  . ALA   A 1 288 ? 18.236  -8.033  13.954  1.000 12.015 0 485  ALA   A CA  1 ? 
ATOM   2295 C C   . ALA   A 1 288 ? 18.925  -8.933  12.919  1.000 12.086 0 485  ALA   A C   1 ? 
ATOM   2296 O O   . ALA   A 1 288 ? 18.212  -9.590  12.142  1.000 12.085 0 485  ALA   A O   1 ? 
ATOM   2297 C CB  . ALA   A 1 288 ? 18.203  -6.589  13.516  1.000 11.996 0 485  ALA   A CB  1 ? 
ATOM   2298 N N   . LEU   A 1 289 ? 20.261  -8.992  12.933  1.000 12.819 0 486  LEU   A N   1 ? 
ATOM   2299 C CA  . LEU   A 1 289 ? 21.047  -9.792  11.953  1.000 13.500 0 486  LEU   A CA  1 ? 
ATOM   2300 C C   . LEU   A 1 289 ? 20.743  -11.287 12.129  1.000 13.452 0 486  LEU   A C   1 ? 
ATOM   2301 O O   . LEU   A 1 289 ? 20.541  -11.972 11.103  1.000 13.227 0 486  LEU   A O   1 ? 
ATOM   2302 C CB  . LEU   A 1 289 ? 22.541  -9.503  12.128  1.000 14.245 0 486  LEU   A CB  1 ? 
ATOM   2303 C CG  . LEU   A 1 289 ? 23.463  -10.150 11.094  1.000 15.383 0 486  LEU   A CG  1 ? 
ATOM   2304 C CD1 . LEU   A 1 289 ? 23.091  -9.726  9.680   1.000 15.830 0 486  LEU   A CD1 1 ? 
ATOM   2305 C CD2 . LEU   A 1 289 ? 24.915  -9.809  11.384  1.000 15.736 0 486  LEU   A CD2 1 ? 
ATOM   2306 N N   . ARG   A 1 290 ? 20.683  -11.776 13.371  1.000 13.834 0 487  ARG   A N   1 ? 
ATOM   2307 C CA  . ARG   A 1 290 ? 20.347  -13.195 13.672  1.000 14.391 0 487  ARG   A CA  1 ? 
ATOM   2308 C C   . ARG   A 1 290 ? 18.926  -13.493 13.176  1.000 13.599 0 487  ARG   A C   1 ? 
ATOM   2309 O O   . ARG   A 1 290 ? 18.721  -14.563 12.575  1.000 13.648 0 487  ARG   A O   1 ? 
ATOM   2310 C CB  . ARG   A 1 290 ? 20.481  -13.479 15.170  1.000 15.602 0 487  ARG   A CB  1 ? 
ATOM   2311 C CG  . ARG   A 1 290 ? 20.241  -14.930 15.565  1.000 17.074 0 487  ARG   A CG  1 ? 
ATOM   2312 C CD  . ARG   A 1 290 ? 21.152  -15.912 14.849  1.000 18.508 0 487  ARG   A CD  1 ? 
ATOM   2313 N NE  . ARG   A 1 290 ? 20.490  -16.601 13.749  1.000 19.873 0 487  ARG   A NE  1 ? 
ATOM   2314 C CZ  . ARG   A 1 290 ? 21.056  -17.530 12.980  1.000 21.203 0 487  ARG   A CZ  1 ? 
ATOM   2315 N NH1 . ARG   A 1 290 ? 22.317  -17.882 13.174  1.000 21.940 0 487  ARG   A NH1 1 ? 
ATOM   2316 N NH2 . ARG   A 1 290 ? 20.356  -18.102 12.014  1.000 21.461 0 487  ARG   A NH2 1 ? 
ATOM   2317 N N   . ILE   A 1 291 ? 17.979  -12.581 13.410  1.000 12.978 0 488  ILE   A N   1 ? 
ATOM   2318 C CA  . ILE   A 1 291 ? 16.565  -12.745 12.959  1.000 12.671 0 488  ILE   A CA  1 ? 
ATOM   2319 C C   . ILE   A 1 291 ? 16.541  -12.794 11.427  1.000 12.562 0 488  ILE   A C   1 ? 
ATOM   2320 O O   . ILE   A 1 291 ? 15.862  -13.678 10.864  1.000 12.446 0 488  ILE   A O   1 ? 
ATOM   2321 C CB  . ILE   A 1 291 ? 15.662  -11.636 13.531  1.000 12.298 0 488  ILE   A CB  1 ? 
ATOM   2322 C CG1 . ILE   A 1 291 ? 15.515  -11.785 15.048  1.000 12.233 0 488  ILE   A CG1 1 ? 
ATOM   2323 C CG2 . ILE   A 1 291 ? 14.313  -11.627 12.829  1.000 12.191 0 488  ILE   A CG2 1 ? 
ATOM   2324 C CD1 . ILE   A 1 291 ? 14.924  -10.583 15.738  1.000 12.017 0 488  ILE   A CD1 1 ? 
ATOM   2325 N N   . LYS   A 1 292 ? 17.271  -11.889 10.772  1.000 12.807 0 489  LYS   A N   1 ? 
ATOM   2326 C CA  . LYS   A 1 292 ? 17.365  -11.847 9.289   1.000 13.276 0 489  LYS   A CA  1 ? 
ATOM   2327 C C   . LYS   A 1 292 ? 17.879  -13.202 8.781   1.000 13.390 0 489  LYS   A C   1 ? 
ATOM   2328 O O   . LYS   A 1 292 ? 17.271  -13.747 7.844   1.000 13.237 0 489  LYS   A O   1 ? 
ATOM   2329 C CB  . LYS   A 1 292 ? 18.269  -10.699 8.833   1.000 13.444 0 489  LYS   A CB  1 ? 
ATOM   2330 C CG  . LYS   A 1 292 ? 18.438  -10.583 7.325   1.000 13.793 0 489  LYS   A CG  1 ? 
ATOM   2331 C CD  . LYS   A 1 292 ? 19.452  -9.546  6.905   1.000 14.233 0 489  LYS   A CD  1 ? 
ATOM   2332 C CE  . LYS   A 1 292 ? 19.620  -9.479  5.404   1.000 14.810 0 489  LYS   A CE  1 ? 
ATOM   2333 N NZ  . LYS   A 1 292 ? 20.626  -8.465  5.013   1.000 15.207 0 489  LYS   A NZ  1 ? 
ATOM   2334 N N   . LYS   A 1 293 ? 18.949  -13.722 9.389   1.000 13.732 0 490  LYS   A N   1 ? 
ATOM   2335 C CA  . LYS   A 1 293 ? 19.576  -15.021 9.019   1.000 14.218 0 490  LYS   A CA  1 ? 
ATOM   2336 C C   . LYS   A 1 293 ? 18.544  -16.146 9.159   1.000 14.352 0 490  LYS   A C   1 ? 
ATOM   2337 O O   . LYS   A 1 293 ? 18.395  -16.935 8.206   1.000 14.674 0 490  LYS   A O   1 ? 
ATOM   2338 C CB  . LYS   A 1 293 ? 20.804  -15.286 9.895   1.000 14.495 0 490  LYS   A CB  1 ? 
ATOM   2339 N N   . THR   A 1 294 ? 17.846  -16.209 10.296  1.000 14.288 0 491  THR   A N   1 ? 
ATOM   2340 C CA  . THR   A 1 294 ? 16.846  -17.266 10.607  1.000 14.359 0 491  THR   A CA  1 ? 
ATOM   2341 C C   . THR   A 1 294 ? 15.714  -17.238 9.570   1.000 14.269 0 491  THR   A C   1 ? 
ATOM   2342 O O   . THR   A 1 294 ? 15.372  -18.315 9.048   1.000 14.463 0 491  THR   A O   1 ? 
ATOM   2343 C CB  . THR   A 1 294 ? 16.320  -17.122 12.040  1.000 14.635 0 491  THR   A CB  1 ? 
ATOM   2344 O OG1 . THR   A 1 294 ? 17.448  -17.250 12.908  1.000 15.254 0 491  THR   A OG1 1 ? 
ATOM   2345 C CG2 . THR   A 1 294 ? 15.268  -18.152 12.391  1.000 14.800 0 491  THR   A CG2 1 ? 
ATOM   2346 N N   . LEU   A 1 295 ? 15.160  -16.057 9.274   1.000 14.190 0 492  LEU   A N   1 ? 
ATOM   2347 C CA  . LEU   A 1 295 ? 14.003  -15.919 8.347   1.000 14.194 0 492  LEU   A CA  1 ? 
ATOM   2348 C C   . LEU   A 1 295 ? 14.452  -16.185 6.905   1.000 14.709 0 492  LEU   A C   1 ? 
ATOM   2349 O O   . LEU   A 1 295 ? 13.639  -16.719 6.132   1.000 14.321 0 492  LEU   A O   1 ? 
ATOM   2350 C CB  . LEU   A 1 295 ? 13.373  -14.531 8.498   1.000 13.867 0 492  LEU   A CB  1 ? 
ATOM   2351 C CG  . LEU   A 1 295 ? 12.628  -14.295 9.812   1.000 13.678 0 492  LEU   A CG  1 ? 
ATOM   2352 C CD1 . LEU   A 1 295 ? 12.170  -12.850 9.911   1.000 13.740 0 492  LEU   A CD1 1 ? 
ATOM   2353 C CD2 . LEU   A 1 295 ? 11.443  -15.241 9.959   1.000 13.806 0 492  LEU   A CD2 1 ? 
ATOM   2354 N N   . SER   A 1 296 ? 15.695  -15.840 6.558   1.000 15.530 0 493  SER   A N   1 ? 
ATOM   2355 C CA  A SER   A 1 296 ? 16.288  -16.127 5.224   0.500 16.167 0 493  SER   A CA  1 ? 
ATOM   2356 C CA  B SER   A 1 296 ? 16.286  -16.127 5.223   0.500 16.148 0 493  SER   A CA  1 ? 
ATOM   2357 C C   . SER   A 1 296 ? 16.338  -17.644 5.005   1.000 16.523 0 493  SER   A C   1 ? 
ATOM   2358 O O   . SER   A 1 296 ? 15.916  -18.096 3.923   1.000 16.895 0 493  SER   A O   1 ? 
ATOM   2359 C CB  A SER   A 1 296 ? 17.651  -15.503 5.088   0.500 16.262 0 493  SER   A CB  1 ? 
ATOM   2360 C CB  B SER   A 1 296 ? 17.648  -15.501 5.078   0.500 16.222 0 493  SER   A CB  1 ? 
ATOM   2361 O OG  A SER   A 1 296 ? 17.571  -14.090 5.193   0.500 16.496 0 493  SER   A OG  1 ? 
ATOM   2362 O OG  B SER   A 1 296 ? 18.124  -15.634 3.747   0.500 16.407 0 493  SER   A OG  1 ? 
ATOM   2363 N N   . GLN   A 1 297 ? 16.820  -18.382 6.010   1.000 17.495 0 494  GLN   A N   1 ? 
ATOM   2364 C CA  . GLN   A 1 297 ? 16.912  -19.868 5.994   1.000 18.804 0 494  GLN   A CA  1 ? 
ATOM   2365 C C   . GLN   A 1 297 ? 15.499  -20.454 5.881   1.000 18.739 0 494  GLN   A C   1 ? 
ATOM   2366 O O   . GLN   A 1 297 ? 15.289  -21.335 5.026   1.000 19.038 0 494  GLN   A O   1 ? 
ATOM   2367 C CB  . GLN   A 1 297 ? 17.636  -20.373 7.244   1.000 19.958 0 494  GLN   A CB  1 ? 
ATOM   2368 C CG  . GLN   A 1 297 ? 19.115  -20.003 7.275   1.000 21.489 0 494  GLN   A CG  1 ? 
ATOM   2369 C CD  . GLN   A 1 297 ? 19.826  -20.326 8.569   1.000 22.779 0 494  GLN   A CD  1 ? 
ATOM   2370 O OE1 . GLN   A 1 297 ? 21.051  -20.426 8.607   1.000 24.872 0 494  GLN   A OE1 1 ? 
ATOM   2371 N NE2 . GLN   A 1 297 ? 19.076  -20.483 9.648   1.000 23.696 0 494  GLN   A NE2 1 ? 
ATOM   2372 N N   . LEU   A 1 298 ? 14.561  -19.959 6.697   1.000 18.617 0 495  LEU   A N   1 ? 
ATOM   2373 C CA  . LEU   A 1 298 ? 13.146  -20.421 6.727   1.000 18.805 0 495  LEU   A CA  1 ? 
ATOM   2374 C C   . LEU   A 1 298 ? 12.493  -20.242 5.349   1.000 19.522 0 495  LEU   A C   1 ? 
ATOM   2375 O O   . LEU   A 1 298 ? 11.737  -21.145 4.937   1.000 19.716 0 495  LEU   A O   1 ? 
ATOM   2376 C CB  . LEU   A 1 298 ? 12.385  -19.627 7.794   1.000 18.117 0 495  LEU   A CB  1 ? 
ATOM   2377 C CG  . LEU   A 1 298 ? 10.914  -20.003 7.971   1.000 17.657 0 495  LEU   A CG  1 ? 
ATOM   2378 C CD1 . LEU   A 1 298 ? 10.779  -21.394 8.574   1.000 17.675 0 495  LEU   A CD1 1 ? 
ATOM   2379 C CD2 . LEU   A 1 298 ? 10.190  -18.974 8.828   1.000 17.446 0 495  LEU   A CD2 1 ? 
ATOM   2380 N N   . SER   A 1 299 ? 12.776  -19.124 4.670   1.000 20.307 0 496  SER   A N   1 ? 
ATOM   2381 C CA  A SER   A 1 299 ? 12.140  -18.725 3.386   0.500 21.019 0 496  SER   A CA  1 ? 
ATOM   2382 C CA  B SER   A 1 299 ? 12.123  -18.735 3.391   0.500 20.634 0 496  SER   A CA  1 ? 
ATOM   2383 C C   . SER   A 1 299 ? 12.422  -19.766 2.295   1.000 21.364 0 496  SER   A C   1 ? 
ATOM   2384 O O   . SER   A 1 299 ? 11.569  -19.920 1.401   1.000 21.816 0 496  SER   A O   1 ? 
ATOM   2385 C CB  A SER   A 1 299 ? 12.608  -17.352 2.966   0.500 21.167 0 496  SER   A CB  1 ? 
ATOM   2386 C CB  B SER   A 1 299 ? 12.533  -17.348 2.962   0.500 20.355 0 496  SER   A CB  1 ? 
ATOM   2387 O OG  A SER   A 1 299 ? 11.907  -16.899 1.817   0.500 21.676 0 496  SER   A OG  1 ? 
ATOM   2388 O OG  B SER   A 1 299 ? 13.870  -17.335 2.486   0.500 19.820 0 496  SER   A OG  1 ? 
ATOM   2389 N N   . GLN   A 1 300 ? 13.575  -20.442 2.374   1.000 22.823 0 497  GLN   A N   1 ? 
ATOM   2390 C CA  . GLN   A 1 300 ? 14.060  -21.387 1.329   1.000 23.932 0 497  GLN   A CA  1 ? 
ATOM   2391 C C   . GLN   A 1 300 ? 13.800  -22.853 1.710   1.000 24.599 0 497  GLN   A C   1 ? 
ATOM   2392 O O   . GLN   A 1 300 ? 14.155  -23.726 0.895   1.000 24.521 0 497  GLN   A O   1 ? 
ATOM   2393 C CB  . GLN   A 1 300 ? 15.552  -21.154 1.079   1.000 24.735 0 497  GLN   A CB  1 ? 
ATOM   2394 C CG  . GLN   A 1 300 ? 15.873  -19.758 0.559   1.000 25.410 0 497  GLN   A CG  1 ? 
ATOM   2395 C CD  . GLN   A 1 300 ? 15.103  -19.403 -0.692  1.000 26.340 0 497  GLN   A CD  1 ? 
ATOM   2396 O OE1 . GLN   A 1 300 ? 14.362  -18.422 -0.729  1.000 27.684 0 497  GLN   A OE1 1 ? 
ATOM   2397 N NE2 . GLN   A 1 300 ? 15.259  -20.211 -1.729  1.000 26.919 0 497  GLN   A NE2 1 ? 
ATOM   2398 N N   . GLN   A 1 301 ? 13.197  -23.127 2.873   1.000 25.162 0 498  GLN   A N   1 ? 
ATOM   2399 C CA  . GLN   A 1 301 ? 12.983  -24.512 3.383   1.000 26.063 0 498  GLN   A CA  1 ? 
ATOM   2400 C C   . GLN   A 1 301 ? 11.972  -25.256 2.500   1.000 26.111 0 498  GLN   A C   1 ? 
ATOM   2401 O O   . GLN   A 1 301 ? 11.029  -24.611 2.000   1.000 25.600 0 498  GLN   A O   1 ? 
ATOM   2402 C CB  . GLN   A 1 301 ? 12.497  -24.505 4.834   1.000 27.003 0 498  GLN   A CB  1 ? 
ATOM   2403 C CG  . GLN   A 1 301 ? 13.611  -24.289 5.848   1.000 27.691 0 498  GLN   A CG  1 ? 
ATOM   2404 C CD  . GLN   A 1 301 ? 13.145  -24.460 7.273   1.000 28.312 0 498  GLN   A CD  1 ? 
ATOM   2405 O OE1 . GLN   A 1 301 ? 12.050  -24.955 7.538   1.000 29.755 0 498  GLN   A OE1 1 ? 
ATOM   2406 N NE2 . GLN   A 1 301 ? 13.982  -24.050 8.211   1.000 29.116 0 498  GLN   A NE2 1 ? 
ATOM   2407 N N   . GLU   A 1 302 ? 12.169  -26.569 2.331   1.000 26.367 0 499  GLU   A N   1 ? 
ATOM   2408 C CA  . GLU   A 1 302 ? 11.227  -27.487 1.635   1.000 26.589 0 499  GLU   A CA  1 ? 
ATOM   2409 C C   . GLU   A 1 302 ? 9.891   -27.484 2.387   1.000 26.984 0 499  GLU   A C   1 ? 
ATOM   2410 O O   . GLU   A 1 302 ? 9.909   -27.692 3.617   1.000 26.652 0 499  GLU   A O   1 ? 
ATOM   2411 C CB  . GLU   A 1 302 ? 11.811  -28.901 1.570   1.000 26.639 0 499  GLU   A CB  1 ? 
ATOM   2412 C CG  . GLU   A 1 302 ? 11.042  -29.841 0.659   1.000 26.656 0 499  GLU   A CG  1 ? 
ATOM   2413 C CD  . GLU   A 1 302 ? 11.506  -31.287 0.697   1.000 26.495 0 499  GLU   A CD  1 ? 
ATOM   2414 O OE1 . GLU   A 1 302 ? 11.983  -31.731 1.762   1.000 26.636 0 499  GLU   A OE1 1 ? 
ATOM   2415 O OE2 . GLU   A 1 302 ? 11.387  -31.970 -0.340  1.000 26.468 0 499  GLU   A OE2 1 ? 
ATOM   2416 N N   . GLY   A 1 303 ? 8.784   -27.248 1.675   1.000 27.353 0 500  GLY   A N   1 ? 
ATOM   2417 C CA  . GLY   A 1 303 ? 7.428   -27.146 2.251   1.000 27.705 0 500  GLY   A CA  1 ? 
ATOM   2418 C C   . GLY   A 1 303 ? 7.011   -25.703 2.492   1.000 27.901 0 500  GLY   A C   1 ? 
ATOM   2419 O O   . GLY   A 1 303 ? 5.793   -25.462 2.613   1.000 28.226 0 500  GLY   A O   1 ? 
ATOM   2420 N N   . ILE   A 1 304 ? 7.980   -24.781 2.568   1.000 27.978 0 501  ILE   A N   1 ? 
ATOM   2421 C CA  . ILE   A 1 304 ? 7.757   -23.312 2.738   1.000 28.010 0 501  ILE   A CA  1 ? 
ATOM   2422 C C   . ILE   A 1 304 ? 7.925   -22.629 1.375   1.000 28.028 0 501  ILE   A C   1 ? 
ATOM   2423 O O   . ILE   A 1 304 ? 6.974   -21.948 0.936   1.000 28.369 0 501  ILE   A O   1 ? 
ATOM   2424 C CB  . ILE   A 1 304 ? 8.718   -22.730 3.794   1.000 27.972 0 501  ILE   A CB  1 ? 
ATOM   2425 N N   . LYS   A 1 305 ? 9.087   -22.812 0.738   1.000 28.055 0 502  LYS   A N   1 ? 
ATOM   2426 C CA  . LYS   A 1 305 ? 9.445   -22.208 -0.576  1.000 28.180 0 502  LYS   A CA  1 ? 
ATOM   2427 C C   . LYS   A 1 305 ? 8.522   -22.770 -1.664  1.000 28.577 0 502  LYS   A C   1 ? 
ATOM   2428 O O   . LYS   A 1 305 ? 7.852   -22.013 -2.371  1.000 29.481 0 502  LYS   A O   1 ? 
ATOM   2429 C CB  . LYS   A 1 305 ? 10.914  -22.485 -0.911  1.000 28.191 0 502  LYS   A CB  1 ? 
HETATM 2430 C C2  . A1L30 B 2 .   ? 3.854   7.784   4.865   1.000 8.336  0 701  A1L30 A C2  1 ? 
HETATM 2431 C C4  . A1L30 B 2 .   ? 3.650   6.912   2.793   1.000 7.981  0 701  A1L30 A C4  1 ? 
HETATM 2432 C C5  . A1L30 B 2 .   ? 2.368   6.736   3.278   1.000 8.278  0 701  A1L30 A C5  1 ? 
HETATM 2433 C C7  . A1L30 B 2 .   ? 1.142   6.222   2.684   1.000 8.816  0 701  A1L30 A C7  1 ? 
HETATM 2434 C C8  . A1L30 B 2 .   ? -0.143  6.213   3.202   1.000 9.341  0 701  A1L30 A C8  1 ? 
HETATM 2435 C C9  . A1L30 B 2 .   ? -1.004  5.627   2.249   1.000 9.981  0 701  A1L30 A C9  1 ? 
HETATM 2436 C C10 . A1L30 B 2 .   ? -0.210  5.290   1.169   1.000 9.533  0 701  A1L30 A C10 1 ? 
HETATM 2437 C C12 . A1L30 B 2 .   ? 4.234   6.600   1.552   1.000 7.888  0 701  A1L30 A C12 1 ? 
HETATM 2438 C C15 . A1L30 B 2 .   ? 5.602   9.230   5.704   1.000 8.862  0 701  A1L30 A C15 1 ? 
HETATM 2439 C C16 . A1L30 B 2 .   ? 5.973   9.860   4.534   1.000 8.922  0 701  A1L30 A C16 1 ? 
HETATM 2440 C C19 . A1L30 B 2 .   ? 6.575   9.586   6.642   1.000 8.988  0 701  A1L30 A C19 1 ? 
HETATM 2441 N N1  . A1L30 B 2 .   ? 4.458   8.430   5.912   1.000 8.793  0 701  A1L30 A N1  1 ? 
HETATM 2442 N N3  . A1L30 B 2 .   ? 4.474   7.525   3.751   1.000 8.058  0 701  A1L30 A N3  1 ? 
HETATM 2443 S S6  . A1L30 B 2 .   ? 2.205   7.266   4.927   1.000 7.947  0 701  A1L30 A S6  1 ? 
HETATM 2444 N N11 . A1L30 B 2 .   ? 1.064   5.654   1.435   1.000 9.084  0 701  A1L30 A N11 1 ? 
HETATM 2445 N N13 . A1L30 B 2 .   ? 5.539   6.809   1.460   1.000 7.847  0 701  A1L30 A N13 1 ? 
HETATM 2446 O O14 . A1L30 B 2 .   ? 3.585   6.164   0.603   1.000 8.031  0 701  A1L30 A O14 1 ? 
HETATM 2447 N N17 . A1L30 B 2 .   ? 7.115   10.523  4.793   1.000 9.002  0 701  A1L30 A N17 1 ? 
HETATM 2448 N N18 . A1L30 B 2 .   ? 7.487   10.376  6.096   1.000 9.086  0 701  A1L30 A N18 1 ? 
HETATM 2449 C C20 . A1L30 B 2 .   ? 7.873   11.369  3.894   1.000 9.307  0 701  A1L30 A C20 1 ? 
HETATM 2450 C C21 . A1L30 B 2 .   ? 9.323   11.240  4.022   1.000 9.578  0 701  A1L30 A C21 1 ? 
HETATM 2451 C C22 . A1L30 B 2 .   ? 10.567  11.139  3.963   1.000 9.997  0 701  A1L30 A C22 1 ? 
HETATM 2452 C C23 . A1L30 B 2 .   ? 12.023  11.169  3.831   1.000 10.393 0 701  A1L30 A C23 1 ? 
HETATM 2453 C C24 . A1L30 B 2 .   ? 3.897   8.338   7.273   1.000 9.437  0 701  A1L30 A C24 1 ? 
HETATM 2454 C C25 . A1L30 B 2 .   ? 4.069   6.961   7.845   1.000 10.307 0 701  A1L30 A C25 1 ? 
HETATM 2455 C C26 . A1L30 B 2 .   ? 5.373   6.565   8.438   1.000 10.731 0 701  A1L30 A C26 1 ? 
HETATM 2456 C C27 . A1L30 B 2 .   ? 4.191   6.791   9.318   1.000 10.428 0 701  A1L30 A C27 1 ? 
HETATM 2457 C C28 . A1L30 B 2 .   ? -2.445  5.450   2.451   1.000 11.258 0 701  A1L30 A C28 1 ? 
HETATM 2458 O O29 . A1L30 B 2 .   ? -2.823  5.199   3.604   1.000 12.410 0 701  A1L30 A O29 1 ? 
HETATM 2459 N N30 . A1L30 B 2 .   ? -3.374  5.568   1.482   1.000 11.965 0 701  A1L30 A N30 1 ? 
HETATM 2460 C C31 . A1L30 B 2 .   ? -4.785  5.272   1.725   1.000 12.387 0 701  A1L30 A C31 1 ? 
HETATM 2461 C C32 . A1L30 B 2 .   ? -3.081  6.011   0.121   1.000 12.060 0 701  A1L30 A C32 1 ? 
HETATM 2462 C C1  . EDO   C 3 .   ? 6.802   35.675  3.351   1.000 23.216 0 702  EDO   A C1  1 ? 
HETATM 2463 O O1  . EDO   C 3 .   ? 7.034   35.537  1.965   1.000 23.218 0 702  EDO   A O1  1 ? 
HETATM 2464 C C2  . EDO   C 3 .   ? 5.506   35.099  3.787   1.000 23.198 0 702  EDO   A C2  1 ? 
HETATM 2465 O O2  . EDO   C 3 .   ? 5.505   33.683  3.841   1.000 22.619 0 702  EDO   A O2  1 ? 
HETATM 2466 C C1  . EDO   D 3 .   ? 11.599  0.742   19.887  1.000 14.829 0 703  EDO   A C1  1 ? 
HETATM 2467 O O1  . EDO   D 3 .   ? 11.705  0.981   18.505  1.000 13.218 0 703  EDO   A O1  1 ? 
HETATM 2468 C C2  . EDO   D 3 .   ? 10.226  0.958   20.393  1.000 15.231 0 703  EDO   A C2  1 ? 
HETATM 2469 O O2  . EDO   D 3 .   ? 9.982   0.254   21.592  1.000 16.201 0 703  EDO   A O2  1 ? 
HETATM 2470 C C1  . EDO   E 3 .   ? -7.626  -10.678 1.608   1.000 22.804 0 704  EDO   A C1  1 ? 
HETATM 2471 O O1  . EDO   E 3 .   ? -6.238  -10.735 1.862   1.000 21.925 0 704  EDO   A O1  1 ? 
HETATM 2472 C C2  . EDO   E 3 .   ? -8.330  -11.928 1.984   1.000 22.719 0 704  EDO   A C2  1 ? 
HETATM 2473 O O2  . EDO   E 3 .   ? -8.277  -12.193 3.372   1.000 22.613 0 704  EDO   A O2  1 ? 
HETATM 2474 C C1  . EDO   F 3 .   ? 25.135  18.732  11.605  1.000 24.371 0 705  EDO   A C1  1 ? 
HETATM 2475 O O1  . EDO   F 3 .   ? 26.451  19.192  11.377  1.000 23.838 0 705  EDO   A O1  1 ? 
HETATM 2476 C C2  . EDO   F 3 .   ? 24.100  19.660  11.095  1.000 24.199 0 705  EDO   A C2  1 ? 
HETATM 2477 O O2  . EDO   F 3 .   ? 24.183  20.966  11.640  1.000 24.659 0 705  EDO   A O2  1 ? 
HETATM 2478 O O   . HOH   G 4 .   ? 3.103   37.295  0.412   1.000 20.144 0 801  HOH   A O   1 ? 
HETATM 2479 O O   . HOH   G 4 .   ? 5.250   36.190  0.451   1.000 29.811 0 802  HOH   A O   1 ? 
HETATM 2480 O O   . HOH   G 4 .   ? 6.793   13.319  12.322  1.000 23.814 0 803  HOH   A O   1 ? 
HETATM 2481 O O   . HOH   G 4 .   ? -4.946  3.285   4.526   1.000 20.563 0 804  HOH   A O   1 ? 
HETATM 2482 O O   . HOH   G 4 .   ? 35.798  6.394   -1.106  1.000 30.209 0 805  HOH   A O   1 ? 
HETATM 2483 O O   . HOH   G 4 .   ? 6.424   11.271  -14.126 1.000 19.323 0 806  HOH   A O   1 ? 
HETATM 2484 O O   . HOH   G 4 .   ? -9.751  -6.512  9.751   1.000 18.037 0 807  HOH   A O   1 ? 
HETATM 2485 O O   . HOH   G 4 .   ? 32.516  1.822   25.787  1.000 19.843 0 808  HOH   A O   1 ? 
HETATM 2486 O O   . HOH   G 4 .   ? 5.678   7.509   14.104  1.000 25.899 0 809  HOH   A O   1 ? 
HETATM 2487 O O   . HOH   G 4 .   ? -6.472  -18.945 16.919  1.000 26.332 0 810  HOH   A O   1 ? 
HETATM 2488 O O   . HOH   G 4 .   ? 0.679   5.208   9.830   1.000 17.550 0 811  HOH   A O   1 ? 
HETATM 2489 O O   . HOH   G 4 .   ? 5.350   -2.657  25.472  1.000 8.994  0 812  HOH   A O   1 ? 
HETATM 2490 O O   . HOH   G 4 .   ? 15.177  1.899   20.606  1.000 12.993 0 813  HOH   A O   1 ? 
HETATM 2491 O O   . HOH   G 4 .   ? 0.901   -5.546  -4.282  1.000 28.157 0 814  HOH   A O   1 ? 
HETATM 2492 O O   . HOH   G 4 .   ? 7.431   32.651  5.465   1.000 23.805 0 815  HOH   A O   1 ? 
HETATM 2493 O O   . HOH   G 4 .   ? -6.183  -12.549 24.718  1.000 28.310 0 816  HOH   A O   1 ? 
HETATM 2494 O O   . HOH   G 4 .   ? 3.394   36.380  6.196   1.000 30.015 0 817  HOH   A O   1 ? 
HETATM 2495 O O   . HOH   G 4 .   ? 2.372   23.388  14.203  1.000 15.935 0 818  HOH   A O   1 ? 
HETATM 2496 O O   . HOH   G 4 .   ? 6.326   -9.343  39.382  1.000 25.220 0 819  HOH   A O   1 ? 
HETATM 2497 O O   . HOH   G 4 .   ? -2.335  5.908   33.908  1.000 24.062 0 820  HOH   A O   1 ? 
HETATM 2498 O O   . HOH   G 4 .   ? 11.260  1.500   23.545  1.000 14.530 0 821  HOH   A O   1 ? 
HETATM 2499 O O   . HOH   G 4 .   ? -2.861  5.542   -4.404  1.000 30.968 0 822  HOH   A O   1 ? 
HETATM 2500 O O   . HOH   G 4 .   ? 21.130  17.600  15.126  1.000 27.139 0 823  HOH   A O   1 ? 
HETATM 2501 O O   . HOH   G 4 .   ? 18.509  8.143   2.596   1.000 12.343 0 824  HOH   A O   1 ? 
HETATM 2502 O O   . HOH   G 4 .   ? 31.812  1.926   20.646  1.000 24.545 0 825  HOH   A O   1 ? 
HETATM 2503 O O   . HOH   G 4 .   ? 17.805  -2.317  26.226  1.000 16.551 0 826  HOH   A O   1 ? 
HETATM 2504 O O   . HOH   G 4 .   ? 11.034  3.546   -0.642  1.000 8.928  0 827  HOH   A O   1 ? 
HETATM 2505 O O   . HOH   G 4 .   ? -9.960  -6.702  14.359  1.000 25.669 0 828  HOH   A O   1 ? 
HETATM 2506 O O   . HOH   G 4 .   ? 9.739   9.357   7.452   1.000 9.198  0 829  HOH   A O   1 ? 
HETATM 2507 O O   . HOH   G 4 .   ? 7.575   29.506  14.156  1.000 22.372 0 830  HOH   A O   1 ? 
HETATM 2508 O O   . HOH   G 4 .   ? 17.680  -20.312 -2.838  1.000 27.327 0 831  HOH   A O   1 ? 
HETATM 2509 O O   . HOH   G 4 .   ? -2.561  14.889  5.899   1.000 23.120 0 832  HOH   A O   1 ? 
HETATM 2510 O O   . HOH   G 4 .   ? 24.200  -10.941 15.355  1.000 22.949 0 833  HOH   A O   1 ? 
HETATM 2511 O O   . HOH   G 4 .   ? -4.751  -12.950 21.685  1.000 23.364 0 834  HOH   A O   1 ? 
HETATM 2512 O O   . HOH   G 4 .   ? 2.018   -12.899 35.916  1.000 29.473 0 835  HOH   A O   1 ? 
HETATM 2513 O O   . HOH   G 4 .   ? 25.555  -1.741  16.037  1.000 23.726 0 836  HOH   A O   1 ? 
HETATM 2514 O O   . HOH   G 4 .   ? 11.626  -3.989  33.071  1.000 27.238 0 837  HOH   A O   1 ? 
HETATM 2515 O O   . HOH   G 4 .   ? 1.303   -1.299  40.602  1.000 26.842 0 838  HOH   A O   1 ? 
HETATM 2516 O O   . HOH   G 4 .   ? -4.999  3.843   10.197  1.000 21.316 0 839  HOH   A O   1 ? 
HETATM 2517 O O   . HOH   G 4 .   ? 23.588  1.617   1.897   1.000 17.216 0 840  HOH   A O   1 ? 
HETATM 2518 O O   . HOH   G 4 .   ? 10.030  -14.359 26.331  1.000 19.978 0 841  HOH   A O   1 ? 
HETATM 2519 O O   . HOH   G 4 .   ? 3.059   -19.006 -1.358  1.000 33.470 0 842  HOH   A O   1 ? 
HETATM 2520 O O   . HOH   G 4 .   ? 14.131  4.173   -3.582  1.000 16.487 0 843  HOH   A O   1 ? 
HETATM 2521 O O   . HOH   G 4 .   ? 1.543   23.400  0.103   1.000 23.100 0 844  HOH   A O   1 ? 
HETATM 2522 O O   . HOH   G 4 .   ? 2.856   6.886   12.774  1.000 31.882 0 845  HOH   A O   1 ? 
HETATM 2523 O O   . HOH   G 4 .   ? -5.290  5.310   28.976  1.000 28.398 0 846  HOH   A O   1 ? 
HETATM 2524 O O   . HOH   G 4 .   ? 5.544   9.071   24.501  1.000 28.998 0 847  HOH   A O   1 ? 
HETATM 2525 O O   . HOH   G 4 .   ? 16.532  -6.900  1.941   1.000 19.280 0 848  HOH   A O   1 ? 
HETATM 2526 O O   . HOH   G 4 .   ? 10.472  32.771  1.857   1.000 29.456 0 849  HOH   A O   1 ? 
HETATM 2527 O O   . HOH   G 4 .   ? 16.175  11.941  16.928  1.000 9.871  0 850  HOH   A O   1 ? 
HETATM 2528 O O   . HOH   G 4 .   ? 10.186  14.223  12.651  1.000 20.194 0 851  HOH   A O   1 ? 
HETATM 2529 O O   . HOH   G 4 .   ? 3.531   -1.749  42.319  1.000 30.462 0 852  HOH   A O   1 ? 
HETATM 2530 O O   . HOH   G 4 .   ? 4.479   -21.679 1.941   1.000 30.869 0 853  HOH   A O   1 ? 
HETATM 2531 O O   . HOH   G 4 .   ? 22.840  -5.139  12.350  1.000 15.678 0 854  HOH   A O   1 ? 
HETATM 2532 O O   . HOH   G 4 .   ? 9.042   -7.716  31.964  1.000 16.042 0 855  HOH   A O   1 ? 
HETATM 2533 O O   . HOH   G 4 .   ? -0.597  5.647   24.107  1.000 13.712 0 856  HOH   A O   1 ? 
HETATM 2534 O O   . HOH   G 4 .   ? -6.402  -3.827  18.507  1.000 12.370 0 857  HOH   A O   1 ? 
HETATM 2535 O O   . HOH   G 4 .   ? 15.985  -9.376  2.939   1.000 24.744 0 858  HOH   A O   1 ? 
HETATM 2536 O O   . HOH   G 4 .   ? 12.072  -4.636  -1.612  1.000 29.746 0 859  HOH   A O   1 ? 
HETATM 2537 O O   . HOH   G 4 .   ? 30.320  -3.077  12.131  1.000 23.549 0 860  HOH   A O   1 ? 
HETATM 2538 O O   . HOH   G 4 .   ? 10.263  7.836   -6.047  1.000 15.441 0 861  HOH   A O   1 ? 
HETATM 2539 O O   . HOH   G 4 .   ? 20.612  -8.543  22.815  1.000 17.805 0 862  HOH   A O   1 ? 
HETATM 2540 O O   . HOH   G 4 .   ? 0.542   -29.695 10.606  1.000 27.165 0 863  HOH   A O   1 ? 
HETATM 2541 O O   . HOH   G 4 .   ? 23.661  16.312  14.941  1.000 38.342 0 864  HOH   A O   1 ? 
HETATM 2542 O O   . HOH   G 4 .   ? 10.765  15.017  17.012  1.000 26.311 0 865  HOH   A O   1 ? 
HETATM 2543 O O   . HOH   G 4 .   ? 2.621   -0.160  -1.897  1.000 11.971 0 866  HOH   A O   1 ? 
HETATM 2544 O O   . HOH   G 4 .   ? 4.301   -10.169 1.599   1.000 14.418 0 867  HOH   A O   1 ? 
HETATM 2545 O O   . HOH   G 4 .   ? -3.193  -1.429  2.486   1.000 15.237 0 868  HOH   A O   1 ? 
HETATM 2546 O O   . HOH   G 4 .   ? -4.572  -5.440  32.632  1.000 15.885 0 869  HOH   A O   1 ? 
HETATM 2547 O O   . HOH   G 4 .   ? 7.672   -22.016 18.692  1.000 22.000 0 870  HOH   A O   1 ? 
HETATM 2548 O O   . HOH   G 4 .   ? 12.643  14.531  14.646  1.000 26.836 0 871  HOH   A O   1 ? 
HETATM 2549 O O   . HOH   G 4 .   ? 10.238  -2.888  36.528  1.000 23.912 0 872  HOH   A O   1 ? 
HETATM 2550 O O   . HOH   G 4 .   ? 0.477   5.011   17.359  1.000 20.024 0 873  HOH   A O   1 ? 
HETATM 2551 O O   . HOH   G 4 .   ? -3.874  -1.764  -0.161  1.000 15.575 0 874  HOH   A O   1 ? 
HETATM 2552 O O   . HOH   G 4 .   ? 7.830   2.709   21.463  1.000 13.009 0 875  HOH   A O   1 ? 
HETATM 2553 O O   . HOH   G 4 .   ? 17.135  -17.153 23.982  1.000 35.472 0 876  HOH   A O   1 ? 
HETATM 2554 O O   . HOH   G 4 .   ? 19.186  -7.268  20.628  1.000 16.372 0 877  HOH   A O   1 ? 
HETATM 2555 O O   . HOH   G 4 .   ? 20.242  -0.215  29.674  1.000 22.706 0 878  HOH   A O   1 ? 
HETATM 2556 O O   . HOH   G 4 .   ? 10.693  6.416   -10.971 1.000 21.764 0 879  HOH   A O   1 ? 
HETATM 2557 O O   . HOH   G 4 .   ? 4.747   27.417  9.291   1.000 13.960 0 880  HOH   A O   1 ? 
HETATM 2558 O O   . HOH   G 4 .   ? 2.076   22.514  -2.465  1.000 16.380 0 881  HOH   A O   1 ? 
HETATM 2559 O O   . HOH   G 4 .   ? -6.697  -0.787  5.647   1.000 26.774 0 882  HOH   A O   1 ? 
HETATM 2560 O O   . HOH   G 4 .   ? 8.872   25.675  18.410  1.000 32.962 0 883  HOH   A O   1 ? 
HETATM 2561 O O   . HOH   G 4 .   ? 3.818   24.290  -6.457  1.000 24.379 0 884  HOH   A O   1 ? 
HETATM 2562 O O   . HOH   G 4 .   ? -8.055  -2.368  14.098  1.000 19.756 0 885  HOH   A O   1 ? 
HETATM 2563 O O   . HOH   G 4 .   ? 20.205  -5.887  6.211   1.000 15.507 0 886  HOH   A O   1 ? 
HETATM 2564 O O   . HOH   G 4 .   ? 2.876   -14.649 25.800  1.000 16.947 0 887  HOH   A O   1 ? 
HETATM 2565 O O   . HOH   G 4 .   ? 16.935  19.420  15.228  1.000 20.554 0 888  HOH   A O   1 ? 
HETATM 2566 O O   . HOH   G 4 .   ? 4.711   33.598  8.180   1.000 19.906 0 889  HOH   A O   1 ? 
HETATM 2567 O O   . HOH   G 4 .   ? -1.426  3.938   5.619   1.000 9.199  0 890  HOH   A O   1 ? 
HETATM 2568 O O   . HOH   G 4 .   ? 23.335  13.312  8.508   1.000 16.250 0 891  HOH   A O   1 ? 
HETATM 2569 O O   . HOH   G 4 .   ? -8.163  -3.069  22.954  1.000 29.396 0 892  HOH   A O   1 ? 
HETATM 2570 O O   . HOH   G 4 .   ? 1.570   -10.077 1.942   1.000 19.545 0 893  HOH   A O   1 ? 
HETATM 2571 O O   . HOH   G 4 .   ? 2.305   -16.039 -1.505  1.000 28.434 0 894  HOH   A O   1 ? 
HETATM 2572 O O   . HOH   G 4 .   ? 9.394   -18.206 0.836   1.000 25.526 0 895  HOH   A O   1 ? 
HETATM 2573 O O   . HOH   G 4 .   ? 12.862  -19.830 23.217  1.000 26.795 0 896  HOH   A O   1 ? 
HETATM 2574 O O   . HOH   G 4 .   ? -9.682  -4.798  20.253  1.000 27.018 0 897  HOH   A O   1 ? 
HETATM 2575 O O   . HOH   G 4 .   ? -9.146  -9.628  4.643   1.000 27.119 0 898  HOH   A O   1 ? 
HETATM 2576 O O   . HOH   G 4 .   ? 34.750  7.375   25.375  1.000 32.692 0 899  HOH   A O   1 ? 
HETATM 2577 O O   . HOH   G 4 .   ? -2.740  -11.653 23.156  1.000 12.251 0 900  HOH   A O   1 ? 
HETATM 2578 O O   . HOH   G 4 .   ? 20.254  -5.743  16.277  1.000 12.666 0 901  HOH   A O   1 ? 
HETATM 2579 O O   . HOH   G 4 .   ? -5.145  2.403   16.672  1.000 19.996 0 902  HOH   A O   1 ? 
HETATM 2580 O O   . HOH   G 4 .   ? 21.549  8.537   2.587   1.000 16.809 0 903  HOH   A O   1 ? 
HETATM 2581 O O   . HOH   G 4 .   ? 0.104   8.342   7.409   1.000 24.114 0 904  HOH   A O   1 ? 
HETATM 2582 O O   . HOH   G 4 .   ? 15.418  -20.950 9.923   1.000 31.239 0 905  HOH   A O   1 ? 
HETATM 2583 O O   . HOH   G 4 .   ? 21.556  -12.111 21.008  1.000 24.027 0 906  HOH   A O   1 ? 
HETATM 2584 O O   . HOH   G 4 .   ? 26.682  4.561   23.702  1.000 19.336 0 907  HOH   A O   1 ? 
HETATM 2585 O O   . HOH   G 4 .   ? -4.123  2.516   21.132  1.000 20.412 0 908  HOH   A O   1 ? 
HETATM 2586 O O   . HOH   G 4 .   ? -1.672  -8.978  23.344  1.000 10.778 0 909  HOH   A O   1 ? 
HETATM 2587 O O   . HOH   G 4 .   ? -7.862  11.927  2.039   1.000 30.043 0 910  HOH   A O   1 ? 
HETATM 2588 O O   . HOH   G 4 .   ? 7.500   7.449   -5.687  1.000 12.562 0 911  HOH   A O   1 ? 
HETATM 2589 O O   . HOH   G 4 .   ? 16.584  -4.460  29.374  1.000 20.779 0 912  HOH   A O   1 ? 
HETATM 2590 O O   . HOH   G 4 .   ? 13.121  1.737   -0.201  1.000 12.852 0 913  HOH   A O   1 ? 
HETATM 2591 O O   . HOH   G 4 .   ? -6.571  11.962  -7.004  1.000 21.313 0 914  HOH   A O   1 ? 
HETATM 2592 O O   . HOH   G 4 .   ? 4.348   29.966  10.798  1.000 15.411 0 915  HOH   A O   1 ? 
HETATM 2593 O O   . HOH   G 4 .   ? 31.837  -2.479  8.411   1.000 16.807 0 916  HOH   A O   1 ? 
HETATM 2594 O O   . HOH   G 4 .   ? 8.944   -26.308 -0.954  1.000 27.832 0 917  HOH   A O   1 ? 
HETATM 2595 O O   . HOH   G 4 .   ? 16.776  27.142  8.809   1.000 30.634 0 918  HOH   A O   1 ? 
HETATM 2596 O O   . HOH   G 4 .   ? 12.276  7.387   14.794  1.000 11.577 0 919  HOH   A O   1 ? 
HETATM 2597 O O   . HOH   G 4 .   ? -0.917  -5.771  35.497  1.000 13.138 0 920  HOH   A O   1 ? 
HETATM 2598 O O   . HOH   G 4 .   ? -9.551  -8.392  11.659  1.000 16.403 0 921  HOH   A O   1 ? 
HETATM 2599 O O   . HOH   G 4 .   ? -5.443  -1.750  23.672  1.000 11.696 0 922  HOH   A O   1 ? 
HETATM 2600 O O   . HOH   G 4 .   ? -0.737  -13.164 35.547  1.000 21.042 0 923  HOH   A O   1 ? 
HETATM 2601 O O   . HOH   G 4 .   ? -9.992  -3.921  10.680  1.000 16.725 0 924  HOH   A O   1 ? 
HETATM 2602 O O   . HOH   G 4 .   ? -1.609  3.657   9.829   1.000 19.456 0 925  HOH   A O   1 ? 
HETATM 2603 O O   . HOH   G 4 .   ? -10.034 -9.815  7.350   1.000 25.141 0 926  HOH   A O   1 ? 
HETATM 2604 O O   . HOH   G 4 .   ? 7.036   2.326   18.873  1.000 10.658 0 927  HOH   A O   1 ? 
HETATM 2605 O O   . HOH   G 4 .   ? 14.087  7.783   -3.278  1.000 12.126 0 928  HOH   A O   1 ? 
HETATM 2606 O O   . HOH   G 4 .   ? 16.328  6.569   2.011   1.000 8.546  0 929  HOH   A O   1 ? 
HETATM 2607 O O   . HOH   G 4 .   ? 14.179  3.033   37.114  1.000 25.556 0 930  HOH   A O   1 ? 
HETATM 2608 O O   . HOH   G 4 .   ? -2.481  -1.700  33.474  1.000 12.492 0 931  HOH   A O   1 ? 
HETATM 2609 O O   . HOH   G 4 .   ? 11.783  -11.810 30.682  1.000 18.065 0 932  HOH   A O   1 ? 
HETATM 2610 O O   . HOH   G 4 .   ? 26.844  -0.698  20.377  1.000 32.965 0 933  HOH   A O   1 ? 
HETATM 2611 O O   . HOH   G 4 .   ? 21.058  16.687  22.154  1.000 29.775 0 934  HOH   A O   1 ? 
HETATM 2612 O O   . HOH   G 4 .   ? 5.299   0.419   -3.852  1.000 14.407 0 935  HOH   A O   1 ? 
HETATM 2613 O O   . HOH   G 4 .   ? 12.779  5.478   29.901  1.000 21.871 0 936  HOH   A O   1 ? 
HETATM 2614 O O   . HOH   G 4 .   ? -4.378  -14.908 2.519   1.000 27.300 0 937  HOH   A O   1 ? 
HETATM 2615 O O   . HOH   G 4 .   ? 24.687  15.137  10.681  1.000 20.306 0 938  HOH   A O   1 ? 
HETATM 2616 O O   . HOH   G 4 .   ? 7.756   4.082   -5.008  1.000 25.199 0 939  HOH   A O   1 ? 
HETATM 2617 O O   . HOH   G 4 .   ? 10.506  30.260  2.933   1.000 24.009 0 940  HOH   A O   1 ? 
HETATM 2618 O O   . HOH   G 4 .   ? 8.862   8.234   15.045  1.000 23.457 0 941  HOH   A O   1 ? 
HETATM 2619 O O   . HOH   G 4 .   ? -9.030  -13.706 16.457  1.000 23.322 0 942  HOH   A O   1 ? 
HETATM 2620 O O   . HOH   G 4 .   ? 23.056  -7.358  22.283  1.000 35.448 0 943  HOH   A O   1 ? 
HETATM 2621 O O   . HOH   G 4 .   ? 16.371  3.882   1.155   1.000 9.250  0 944  HOH   A O   1 ? 
HETATM 2622 O O   . HOH   G 4 .   ? 1.916   20.620  8.739   1.000 28.742 0 945  HOH   A O   1 ? 
HETATM 2623 O O   . HOH   G 4 .   ? 27.115  -2.852  13.835  1.000 22.128 0 946  HOH   A O   1 ? 
HETATM 2624 O O   . HOH   G 4 .   ? -4.514  -1.876  31.763  1.000 17.002 0 947  HOH   A O   1 ? 
HETATM 2625 O O   . HOH   G 4 .   ? 15.112  -17.909 17.007  1.000 30.113 0 948  HOH   A O   1 ? 
HETATM 2626 O O   . HOH   G 4 .   ? -7.823  -16.345 3.903   1.000 33.716 0 949  HOH   A O   1 ? 
HETATM 2627 O O   . HOH   G 4 .   ? 18.852  9.275   -0.019  1.000 16.907 0 950  HOH   A O   1 ? 
HETATM 2628 O O   . HOH   G 4 .   ? -10.208 -11.129 10.271  1.000 26.695 0 951  HOH   A O   1 ? 
HETATM 2629 O O   . HOH   G 4 .   ? 10.030  3.769   22.488  1.000 22.698 0 952  HOH   A O   1 ? 
HETATM 2630 O O   . HOH   G 4 .   ? 3.617   8.226   15.547  1.000 30.521 0 953  HOH   A O   1 ? 
HETATM 2631 O O   . HOH   G 4 .   ? 28.397  3.230   14.699  1.000 15.743 0 954  HOH   A O   1 ? 
HETATM 2632 O O   . HOH   G 4 .   ? 23.738  -3.318  5.768   1.000 28.543 0 955  HOH   A O   1 ? 
HETATM 2633 O O   . HOH   G 4 .   ? 9.942   20.330  16.753  1.000 24.895 0 956  HOH   A O   1 ? 
HETATM 2634 O O   . HOH   G 4 .   ? -2.736  -8.553  14.250  1.000 10.890 0 957  HOH   A O   1 ? 
HETATM 2635 O O   . HOH   G 4 .   ? 19.052  -2.613  -0.457  1.000 17.932 0 958  HOH   A O   1 ? 
HETATM 2636 O O   . HOH   G 4 .   ? 9.623   10.598  12.477  1.000 15.562 0 959  HOH   A O   1 ? 
HETATM 2637 O O   . HOH   G 4 .   ? 3.608   -11.327 -0.867  1.000 25.223 0 960  HOH   A O   1 ? 
HETATM 2638 O O   . HOH   G 4 .   ? 20.452  -8.877  2.148   1.000 30.684 0 961  HOH   A O   1 ? 
HETATM 2639 O O   . HOH   G 4 .   ? 11.071  0.950   -3.769  1.000 25.423 0 962  HOH   A O   1 ? 
HETATM 2640 O O   . HOH   G 4 .   ? 8.085   -1.464  37.361  1.000 25.318 0 963  HOH   A O   1 ? 
HETATM 2641 O O   . HOH   G 4 .   ? 20.563  -3.376  27.385  1.000 31.896 0 964  HOH   A O   1 ? 
HETATM 2642 O O   . HOH   G 4 .   ? 11.144  23.283  16.524  1.000 19.212 0 965  HOH   A O   1 ? 
HETATM 2643 O O   . HOH   G 4 .   ? 8.899   -15.722 1.652   1.000 21.264 0 966  HOH   A O   1 ? 
HETATM 2644 O O   . HOH   G 4 .   ? 17.343  17.518  0.382   1.000 14.872 0 967  HOH   A O   1 ? 
HETATM 2645 O O   . HOH   G 4 .   ? 1.604   -17.037 25.022  1.000 22.788 0 968  HOH   A O   1 ? 
HETATM 2646 O O   . HOH   G 4 .   ? 4.118   -23.516 4.076   1.000 29.127 0 969  HOH   A O   1 ? 
HETATM 2647 O O   . HOH   G 4 .   ? -0.970  26.593  1.167   1.000 20.782 0 970  HOH   A O   1 ? 
HETATM 2648 O O   . HOH   G 4 .   ? 13.015  -19.220 15.581  1.000 21.399 0 971  HOH   A O   1 ? 
HETATM 2649 O O   . HOH   G 4 .   ? 6.025   30.747  8.465   1.000 15.758 0 972  HOH   A O   1 ? 
HETATM 2650 O O   . HOH   G 4 .   ? 2.683   -13.692 28.493  1.000 14.187 0 973  HOH   A O   1 ? 
HETATM 2651 O O   . HOH   G 4 .   ? 3.082   1.673   -4.835  1.000 19.778 0 974  HOH   A O   1 ? 
HETATM 2652 O O   . HOH   G 4 .   ? 32.794  2.355   4.734   1.000 29.209 0 975  HOH   A O   1 ? 
HETATM 2653 O O   . HOH   G 4 .   ? 3.384   7.314   -9.956  1.000 29.770 0 976  HOH   A O   1 ? 
HETATM 2654 O O   . HOH   G 4 .   ? -1.237  2.436   20.570  1.000 14.572 0 977  HOH   A O   1 ? 
HETATM 2655 O O   . HOH   G 4 .   ? 13.082  -6.801  0.688   1.000 20.278 0 978  HOH   A O   1 ? 
HETATM 2656 O O   . HOH   G 4 .   ? 1.278   0.521   15.287  1.000 10.276 0 979  HOH   A O   1 ? 
HETATM 2657 O O   . HOH   G 4 .   ? 26.388  10.748  7.836   1.000 16.732 0 980  HOH   A O   1 ? 
HETATM 2658 O O   . HOH   G 4 .   ? 1.849   8.193   30.118  1.000 16.076 0 981  HOH   A O   1 ? 
HETATM 2659 O O   . HOH   G 4 .   ? 36.278  2.086   19.408  1.000 27.520 0 982  HOH   A O   1 ? 
HETATM 2660 O O   . HOH   G 4 .   ? 1.851   6.699   22.875  1.000 17.525 0 983  HOH   A O   1 ? 
HETATM 2661 O O   . HOH   G 4 .   ? 21.897  -6.849  14.236  1.000 13.124 0 984  HOH   A O   1 ? 
HETATM 2662 O O   . HOH   G 4 .   ? 26.335  9.284   24.765  1.000 33.729 0 985  HOH   A O   1 ? 
HETATM 2663 O O   . HOH   G 4 .   ? 26.781  0.792   22.910  1.000 22.117 0 986  HOH   A O   1 ? 
HETATM 2664 O O   . HOH   G 4 .   ? 0.397   -20.313 2.827   1.000 25.900 0 987  HOH   A O   1 ? 
HETATM 2665 O O   . HOH   G 4 .   ? 7.699   -2.820  -4.924  1.000 19.707 0 988  HOH   A O   1 ? 
HETATM 2666 O O   . HOH   G 4 .   ? 0.477   3.671   22.509  1.000 12.558 0 989  HOH   A O   1 ? 
HETATM 2667 O O   . HOH   G 4 .   ? 16.497  -14.116 1.711   1.000 33.210 0 990  HOH   A O   1 ? 
HETATM 2668 O O   . HOH   G 4 .   ? -10.470 -17.803 10.250  1.000 31.327 0 991  HOH   A O   1 ? 
HETATM 2669 O O   . HOH   G 4 .   ? 14.013  -4.535  32.130  1.000 33.483 0 992  HOH   A O   1 ? 
HETATM 2670 O O   . HOH   G 4 .   ? -4.998  -20.553 21.305  1.000 29.557 0 993  HOH   A O   1 ? 
HETATM 2671 O O   . HOH   G 4 .   ? 10.989  -14.004 1.771   1.000 26.214 0 994  HOH   A O   1 ? 
HETATM 2672 O O   . HOH   G 4 .   ? 13.878  5.399   23.728  1.000 27.377 0 995  HOH   A O   1 ? 
HETATM 2673 O O   . HOH   G 4 .   ? 2.708   -19.660 1.281   1.000 17.897 0 996  HOH   A O   1 ? 
HETATM 2674 O O   . HOH   G 4 .   ? 1.723   7.186   32.874  1.000 16.179 0 997  HOH   A O   1 ? 
HETATM 2675 O O   . HOH   G 4 .   ? 33.408  6.325   14.937  1.000 29.874 0 998  HOH   A O   1 ? 
HETATM 2676 O O   . HOH   G 4 .   ? 0.802   24.046  6.351   1.000 28.091 0 999  HOH   A O   1 ? 
HETATM 2677 O O   . HOH   G 4 .   ? 0.419   -12.698 1.311   1.000 16.810 0 1000 HOH   A O   1 ? 
HETATM 2678 O O   . HOH   G 4 .   ? 21.270  -13.053 18.514  1.000 17.958 0 1001 HOH   A O   1 ? 
HETATM 2679 O O   . HOH   G 4 .   ? -5.346  -20.998 18.326  1.000 22.367 0 1002 HOH   A O   1 ? 
HETATM 2680 O O   . HOH   G 4 .   ? 34.841  4.195   3.911   1.000 28.996 0 1003 HOH   A O   1 ? 
HETATM 2681 O O   . HOH   G 4 .   ? 11.000  13.440  -15.916 1.000 25.126 0 1004 HOH   A O   1 ? 
HETATM 2682 O O   . HOH   G 4 .   ? 24.671  -4.345  14.322  1.000 28.026 0 1005 HOH   A O   1 ? 
HETATM 2683 O O   . HOH   G 4 .   ? 15.230  5.566   37.061  1.000 28.192 0 1006 HOH   A O   1 ? 
HETATM 2684 O O   . HOH   G 4 .   ? -0.046  2.201   17.839  1.000 10.094 0 1007 HOH   A O   1 ? 
HETATM 2685 O O   . HOH   G 4 .   ? 30.911  4.687   10.671  1.000 27.093 0 1008 HOH   A O   1 ? 
HETATM 2686 O O   . HOH   G 4 .   ? 15.632  3.104   -1.337  1.000 19.101 0 1009 HOH   A O   1 ? 
HETATM 2687 O O   . HOH   G 4 .   ? 13.392  -9.073  2.166   1.000 27.855 0 1010 HOH   A O   1 ? 
HETATM 2688 O O   . HOH   G 4 .   ? 22.699  -5.350  7.289   1.000 28.697 0 1011 HOH   A O   1 ? 
HETATM 2689 O O   . HOH   G 4 .   ? 20.829  -5.808  18.957  1.000 17.187 0 1012 HOH   A O   1 ? 
HETATM 2690 O O   . HOH   G 4 .   ? 0.121   5.640   7.298   1.000 16.656 0 1013 HOH   A O   1 ? 
HETATM 2691 O O   . HOH   G 4 .   ? 5.298   -15.688 25.219  1.000 29.795 0 1014 HOH   A O   1 ? 
HETATM 2692 O O   . HOH   G 4 .   ? -6.636  -2.357  20.896  1.000 23.978 0 1015 HOH   A O   1 ? 
HETATM 2693 O O   . HOH   G 4 .   ? 8.694   30.641  9.010   1.000 26.906 0 1016 HOH   A O   1 ? 
HETATM 2694 O O   . HOH   G 4 .   ? 13.813  2.912   22.786  1.000 18.497 0 1017 HOH   A O   1 ? 
HETATM 2695 O O   . HOH   G 4 .   ? -5.360  0.457   3.410   1.000 25.645 0 1018 HOH   A O   1 ? 
HETATM 2696 O O   . HOH   G 4 .   ? -2.701  -7.369  -2.075  1.000 37.469 0 1019 HOH   A O   1 ? 
HETATM 2697 O O   . HOH   G 4 .   ? 2.961   33.695  10.276  1.000 14.707 0 1020 HOH   A O   1 ? 
HETATM 2698 O O   . HOH   G 4 .   ? -6.735  -2.059  16.353  1.000 21.138 0 1021 HOH   A O   1 ? 
HETATM 2699 O O   . HOH   G 4 .   ? -3.838  0.002   35.133  1.000 23.213 0 1022 HOH   A O   1 ? 
HETATM 2700 O O   . HOH   G 4 .   ? 1.438   9.606   9.745   1.000 24.135 0 1023 HOH   A O   1 ? 
HETATM 2701 O O   . HOH   G 4 .   ? 7.328   -14.221 26.139  1.000 20.362 0 1024 HOH   A O   1 ? 
HETATM 2702 O O   . HOH   G 4 .   ? 0.889   -22.862 3.349   1.000 37.120 0 1025 HOH   A O   1 ? 
# 
