data_9J8C
# 
_entry.id   9J8C 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9J8C         pdb_00009j8c 10.2210/pdb9j8c/pdb 
WWPDB D_1300050554 ?            ?                   
EMDB  EMD-61227    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-03-05 ? 
2 'EM metadata'     1 0 2025-03-05 ? 
3 FSC               1 0 2025-03-05 ? 
4 'Half map'        1 0 2025-03-05 1 
5 'Half map'        1 0 2025-03-05 2 
6 Image             1 0 2025-03-05 ? 
7 'Primary map'     1 0 2025-03-05 ? 
8 'Structure model' 1 1 2025-03-19 ? 
9 'Structure model' 1 2 2025-03-26 ? 
# 
loop_
_pdbx_audit_revision_details.ordinal 
_pdbx_audit_revision_details.revision_ordinal 
_pdbx_audit_revision_details.data_content_type 
_pdbx_audit_revision_details.provider 
_pdbx_audit_revision_details.type 
_pdbx_audit_revision_details.description 
_pdbx_audit_revision_details.details 
1 1 'Structure model' repository 'Initial release' ? ? 
2 2 'EM metadata'     repository 'Initial release' ? ? 
3 3 FSC               repository 'Initial release' ? ? 
4 4 'Half map'        repository 'Initial release' ? ? 
5 5 'Half map'        repository 'Initial release' ? ? 
6 6 Image             repository 'Initial release' ? ? 
7 7 'Primary map'     repository 'Initial release' ? ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 8 'Structure model' 'Data collection'     
2 8 'Structure model' 'Database references' 
3 9 'Structure model' 'Data collection'     
4 9 'Structure model' 'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 8 'Structure model' citation        
2 8 'Structure model' em_admin        
3 9 'Structure model' citation        
4 9 'Structure model' citation_author 
5 9 'Structure model' em_admin        
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  8 'Structure model' '_citation.country'                 
2  8 'Structure model' '_citation.journal_abbrev'          
3  8 'Structure model' '_citation.journal_id_CSD'          
4  8 'Structure model' '_citation.journal_id_ISSN'         
5  8 'Structure model' '_citation.pdbx_database_id_DOI'    
6  8 'Structure model' '_citation.title'                   
7  8 'Structure model' '_citation.year'                    
8  8 'Structure model' '_em_admin.last_update'             
9  9 'Structure model' '_citation.journal_volume'          
10 9 'Structure model' '_citation.page_first'              
11 9 'Structure model' '_citation.page_last'               
12 9 'Structure model' '_citation.pdbx_database_id_PubMed' 
13 9 'Structure model' '_citation.title'                   
14 9 'Structure model' '_em_admin.last_update'             
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9J8C 
_pdbx_database_status.recvd_initial_deposition_date   2024-08-21 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Human Glycine Transporter 1 in the Sarcosine-Bound State with an Occluded Conformation' 
_pdbx_database_related.db_id          EMD-61227 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 5 
_pdbx_contact_author.email              zhaoy@ibp.ac.cn 
_pdbx_contact_author.name_first         Yan 
_pdbx_contact_author.name_last          Zhao 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-4348-256X 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Wei, Y.'  1 ? 
'Li, N.'   2 ? 
'Li, R.'   3 ? 
'Zhao, Y.' 4 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Nat Commun' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2041-1723 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            16 
_citation.language                  ? 
_citation.page_first                2412 
_citation.page_last                 2412 
_citation.title                     'Modulation of the human GlyT1 by clinical drugs and cholesterol.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41467-025-57613-z 
_citation.pdbx_database_id_PubMed   40069141 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Li, N.'   1 ? 
primary 'Wei, Y.'  2 ? 
primary 'Li, R.'   3 ? 
primary 'Meng, Y.' 4 ? 
primary 'Zhao, J.' 5 ? 
primary 'Bai, Q.'  6 ? 
primary 'Wang, G.' 7 ? 
primary 'Zhao, Y.' 8 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Isoform GlyT-1B of Sodium- and chloride-dependent glycine transporter 1' 72533.148 1  ? ? ? ? 
2 non-polymer syn SARCOSINE                                                                 89.093    1  ? ? ? ? 
3 non-polymer syn CHOLESTEROL                                                               386.654   3  ? ? ? ? 
4 non-polymer syn 'CHLORIDE ION'                                                            35.453    1  ? ? ? ? 
5 non-polymer syn 'SODIUM ION'                                                              22.990    2  ? ? ? ? 
6 water       nat water                                                                     18.015    14 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'GlyT-1,GlyT1,Solute carrier family 6 member 9' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MSGGDTRAAIARPRMAAAHGPVAPSSPEQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNG
GGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHV
LPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCL
GVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGC
AWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPIS
PLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASF
SLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGF
LMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVG
SNGSSRLQDSRI
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MSGGDTRAAIARPRMAAAHGPVAPSSPEQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNG
GGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHV
LPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCL
GVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGC
AWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPIS
PLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASF
SLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGF
LMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVG
SNGSSRLQDSRI
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 SARCOSINE      SAR 
3 CHOLESTEROL    CLR 
4 'CHLORIDE ION' CL  
5 'SODIUM ION'   NA  
6 water          HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   SER n 
1 3   GLY n 
1 4   GLY n 
1 5   ASP n 
1 6   THR n 
1 7   ARG n 
1 8   ALA n 
1 9   ALA n 
1 10  ILE n 
1 11  ALA n 
1 12  ARG n 
1 13  PRO n 
1 14  ARG n 
1 15  MET n 
1 16  ALA n 
1 17  ALA n 
1 18  ALA n 
1 19  HIS n 
1 20  GLY n 
1 21  PRO n 
1 22  VAL n 
1 23  ALA n 
1 24  PRO n 
1 25  SER n 
1 26  SER n 
1 27  PRO n 
1 28  GLU n 
1 29  GLN n 
1 30  ASN n 
1 31  GLY n 
1 32  ALA n 
1 33  VAL n 
1 34  PRO n 
1 35  SER n 
1 36  GLU n 
1 37  ALA n 
1 38  THR n 
1 39  LYS n 
1 40  ARG n 
1 41  ASP n 
1 42  GLN n 
1 43  ASN n 
1 44  LEU n 
1 45  LYS n 
1 46  ARG n 
1 47  GLY n 
1 48  ASN n 
1 49  TRP n 
1 50  GLY n 
1 51  ASN n 
1 52  GLN n 
1 53  ILE n 
1 54  GLU n 
1 55  PHE n 
1 56  VAL n 
1 57  LEU n 
1 58  THR n 
1 59  SER n 
1 60  VAL n 
1 61  GLY n 
1 62  TYR n 
1 63  ALA n 
1 64  VAL n 
1 65  GLY n 
1 66  LEU n 
1 67  GLY n 
1 68  ASN n 
1 69  VAL n 
1 70  TRP n 
1 71  ARG n 
1 72  PHE n 
1 73  PRO n 
1 74  TYR n 
1 75  LEU n 
1 76  CYS n 
1 77  TYR n 
1 78  ARG n 
1 79  ASN n 
1 80  GLY n 
1 81  GLY n 
1 82  GLY n 
1 83  ALA n 
1 84  PHE n 
1 85  MET n 
1 86  PHE n 
1 87  PRO n 
1 88  TYR n 
1 89  PHE n 
1 90  ILE n 
1 91  MET n 
1 92  LEU n 
1 93  ILE n 
1 94  PHE n 
1 95  CYS n 
1 96  GLY n 
1 97  ILE n 
1 98  PRO n 
1 99  LEU n 
1 100 PHE n 
1 101 PHE n 
1 102 MET n 
1 103 GLU n 
1 104 LEU n 
1 105 SER n 
1 106 PHE n 
1 107 GLY n 
1 108 GLN n 
1 109 PHE n 
1 110 ALA n 
1 111 SER n 
1 112 GLN n 
1 113 GLY n 
1 114 CYS n 
1 115 LEU n 
1 116 GLY n 
1 117 VAL n 
1 118 TRP n 
1 119 ARG n 
1 120 ILE n 
1 121 SER n 
1 122 PRO n 
1 123 MET n 
1 124 PHE n 
1 125 LYS n 
1 126 GLY n 
1 127 VAL n 
1 128 GLY n 
1 129 TYR n 
1 130 GLY n 
1 131 MET n 
1 132 MET n 
1 133 VAL n 
1 134 VAL n 
1 135 SER n 
1 136 THR n 
1 137 TYR n 
1 138 ILE n 
1 139 GLY n 
1 140 ILE n 
1 141 TYR n 
1 142 TYR n 
1 143 ASN n 
1 144 VAL n 
1 145 VAL n 
1 146 ILE n 
1 147 CYS n 
1 148 ILE n 
1 149 ALA n 
1 150 PHE n 
1 151 TYR n 
1 152 TYR n 
1 153 PHE n 
1 154 PHE n 
1 155 SER n 
1 156 SER n 
1 157 MET n 
1 158 THR n 
1 159 HIS n 
1 160 VAL n 
1 161 LEU n 
1 162 PRO n 
1 163 TRP n 
1 164 ALA n 
1 165 TYR n 
1 166 CYS n 
1 167 ASN n 
1 168 ASN n 
1 169 PRO n 
1 170 TRP n 
1 171 ASN n 
1 172 THR n 
1 173 HIS n 
1 174 ASP n 
1 175 CYS n 
1 176 ALA n 
1 177 GLY n 
1 178 VAL n 
1 179 LEU n 
1 180 ASP n 
1 181 ALA n 
1 182 SER n 
1 183 ASN n 
1 184 LEU n 
1 185 THR n 
1 186 ASN n 
1 187 GLY n 
1 188 SER n 
1 189 ARG n 
1 190 PRO n 
1 191 ALA n 
1 192 ALA n 
1 193 LEU n 
1 194 PRO n 
1 195 SER n 
1 196 ASN n 
1 197 LEU n 
1 198 SER n 
1 199 HIS n 
1 200 LEU n 
1 201 LEU n 
1 202 ASN n 
1 203 HIS n 
1 204 SER n 
1 205 LEU n 
1 206 GLN n 
1 207 ARG n 
1 208 THR n 
1 209 SER n 
1 210 PRO n 
1 211 SER n 
1 212 GLU n 
1 213 GLU n 
1 214 TYR n 
1 215 TRP n 
1 216 ARG n 
1 217 LEU n 
1 218 TYR n 
1 219 VAL n 
1 220 LEU n 
1 221 LYS n 
1 222 LEU n 
1 223 SER n 
1 224 ASP n 
1 225 ASP n 
1 226 ILE n 
1 227 GLY n 
1 228 ASN n 
1 229 PHE n 
1 230 GLY n 
1 231 GLU n 
1 232 VAL n 
1 233 ARG n 
1 234 LEU n 
1 235 PRO n 
1 236 LEU n 
1 237 LEU n 
1 238 GLY n 
1 239 CYS n 
1 240 LEU n 
1 241 GLY n 
1 242 VAL n 
1 243 SER n 
1 244 TRP n 
1 245 LEU n 
1 246 VAL n 
1 247 VAL n 
1 248 PHE n 
1 249 LEU n 
1 250 CYS n 
1 251 LEU n 
1 252 ILE n 
1 253 ARG n 
1 254 GLY n 
1 255 VAL n 
1 256 LYS n 
1 257 SER n 
1 258 SER n 
1 259 GLY n 
1 260 LYS n 
1 261 VAL n 
1 262 VAL n 
1 263 TYR n 
1 264 PHE n 
1 265 THR n 
1 266 ALA n 
1 267 THR n 
1 268 PHE n 
1 269 PRO n 
1 270 TYR n 
1 271 VAL n 
1 272 VAL n 
1 273 LEU n 
1 274 THR n 
1 275 ILE n 
1 276 LEU n 
1 277 PHE n 
1 278 VAL n 
1 279 ARG n 
1 280 GLY n 
1 281 VAL n 
1 282 THR n 
1 283 LEU n 
1 284 GLU n 
1 285 GLY n 
1 286 ALA n 
1 287 PHE n 
1 288 ASP n 
1 289 GLY n 
1 290 ILE n 
1 291 MET n 
1 292 TYR n 
1 293 TYR n 
1 294 LEU n 
1 295 THR n 
1 296 PRO n 
1 297 GLN n 
1 298 TRP n 
1 299 ASP n 
1 300 LYS n 
1 301 ILE n 
1 302 LEU n 
1 303 GLU n 
1 304 ALA n 
1 305 LYS n 
1 306 VAL n 
1 307 TRP n 
1 308 GLY n 
1 309 ASP n 
1 310 ALA n 
1 311 ALA n 
1 312 SER n 
1 313 GLN n 
1 314 ILE n 
1 315 PHE n 
1 316 TYR n 
1 317 SER n 
1 318 LEU n 
1 319 GLY n 
1 320 CYS n 
1 321 ALA n 
1 322 TRP n 
1 323 GLY n 
1 324 GLY n 
1 325 LEU n 
1 326 ILE n 
1 327 THR n 
1 328 MET n 
1 329 ALA n 
1 330 SER n 
1 331 TYR n 
1 332 ASN n 
1 333 LYS n 
1 334 PHE n 
1 335 HIS n 
1 336 ASN n 
1 337 ASN n 
1 338 CYS n 
1 339 TYR n 
1 340 ARG n 
1 341 ASP n 
1 342 SER n 
1 343 VAL n 
1 344 ILE n 
1 345 ILE n 
1 346 SER n 
1 347 ILE n 
1 348 THR n 
1 349 ASN n 
1 350 CYS n 
1 351 ALA n 
1 352 THR n 
1 353 SER n 
1 354 VAL n 
1 355 TYR n 
1 356 ALA n 
1 357 GLY n 
1 358 PHE n 
1 359 VAL n 
1 360 ILE n 
1 361 PHE n 
1 362 SER n 
1 363 ILE n 
1 364 LEU n 
1 365 GLY n 
1 366 PHE n 
1 367 MET n 
1 368 ALA n 
1 369 ASN n 
1 370 HIS n 
1 371 LEU n 
1 372 GLY n 
1 373 VAL n 
1 374 ASP n 
1 375 VAL n 
1 376 SER n 
1 377 ARG n 
1 378 VAL n 
1 379 ALA n 
1 380 ASP n 
1 381 HIS n 
1 382 GLY n 
1 383 PRO n 
1 384 GLY n 
1 385 LEU n 
1 386 ALA n 
1 387 PHE n 
1 388 VAL n 
1 389 ALA n 
1 390 TYR n 
1 391 PRO n 
1 392 GLU n 
1 393 ALA n 
1 394 LEU n 
1 395 THR n 
1 396 LEU n 
1 397 LEU n 
1 398 PRO n 
1 399 ILE n 
1 400 SER n 
1 401 PRO n 
1 402 LEU n 
1 403 TRP n 
1 404 SER n 
1 405 LEU n 
1 406 LEU n 
1 407 PHE n 
1 408 PHE n 
1 409 PHE n 
1 410 MET n 
1 411 LEU n 
1 412 ILE n 
1 413 LEU n 
1 414 LEU n 
1 415 GLY n 
1 416 LEU n 
1 417 GLY n 
1 418 THR n 
1 419 GLN n 
1 420 PHE n 
1 421 CYS n 
1 422 LEU n 
1 423 LEU n 
1 424 GLU n 
1 425 THR n 
1 426 LEU n 
1 427 VAL n 
1 428 THR n 
1 429 ALA n 
1 430 ILE n 
1 431 VAL n 
1 432 ASP n 
1 433 GLU n 
1 434 VAL n 
1 435 GLY n 
1 436 ASN n 
1 437 GLU n 
1 438 TRP n 
1 439 ILE n 
1 440 LEU n 
1 441 GLN n 
1 442 LYS n 
1 443 LYS n 
1 444 THR n 
1 445 TYR n 
1 446 VAL n 
1 447 THR n 
1 448 LEU n 
1 449 GLY n 
1 450 VAL n 
1 451 ALA n 
1 452 VAL n 
1 453 ALA n 
1 454 GLY n 
1 455 PHE n 
1 456 LEU n 
1 457 LEU n 
1 458 GLY n 
1 459 ILE n 
1 460 PRO n 
1 461 LEU n 
1 462 THR n 
1 463 SER n 
1 464 GLN n 
1 465 ALA n 
1 466 GLY n 
1 467 ILE n 
1 468 TYR n 
1 469 TRP n 
1 470 LEU n 
1 471 LEU n 
1 472 LEU n 
1 473 MET n 
1 474 ASP n 
1 475 ASN n 
1 476 TYR n 
1 477 ALA n 
1 478 ALA n 
1 479 SER n 
1 480 PHE n 
1 481 SER n 
1 482 LEU n 
1 483 VAL n 
1 484 VAL n 
1 485 ILE n 
1 486 SER n 
1 487 CYS n 
1 488 ILE n 
1 489 MET n 
1 490 CYS n 
1 491 VAL n 
1 492 ALA n 
1 493 ILE n 
1 494 MET n 
1 495 TYR n 
1 496 ILE n 
1 497 TYR n 
1 498 GLY n 
1 499 HIS n 
1 500 ARG n 
1 501 ASN n 
1 502 TYR n 
1 503 PHE n 
1 504 GLN n 
1 505 ASP n 
1 506 ILE n 
1 507 GLN n 
1 508 MET n 
1 509 MET n 
1 510 LEU n 
1 511 GLY n 
1 512 PHE n 
1 513 PRO n 
1 514 PRO n 
1 515 PRO n 
1 516 LEU n 
1 517 PHE n 
1 518 PHE n 
1 519 GLN n 
1 520 ILE n 
1 521 CYS n 
1 522 TRP n 
1 523 ARG n 
1 524 PHE n 
1 525 VAL n 
1 526 SER n 
1 527 PRO n 
1 528 ALA n 
1 529 ILE n 
1 530 ILE n 
1 531 PHE n 
1 532 PHE n 
1 533 ILE n 
1 534 LEU n 
1 535 VAL n 
1 536 PHE n 
1 537 THR n 
1 538 VAL n 
1 539 ILE n 
1 540 GLN n 
1 541 TYR n 
1 542 GLN n 
1 543 PRO n 
1 544 ILE n 
1 545 THR n 
1 546 TYR n 
1 547 ASN n 
1 548 HIS n 
1 549 TYR n 
1 550 GLN n 
1 551 TYR n 
1 552 PRO n 
1 553 GLY n 
1 554 TRP n 
1 555 ALA n 
1 556 VAL n 
1 557 ALA n 
1 558 ILE n 
1 559 GLY n 
1 560 PHE n 
1 561 LEU n 
1 562 MET n 
1 563 ALA n 
1 564 LEU n 
1 565 SER n 
1 566 SER n 
1 567 VAL n 
1 568 LEU n 
1 569 CYS n 
1 570 ILE n 
1 571 PRO n 
1 572 LEU n 
1 573 TYR n 
1 574 ALA n 
1 575 MET n 
1 576 PHE n 
1 577 ARG n 
1 578 LEU n 
1 579 CYS n 
1 580 ARG n 
1 581 THR n 
1 582 ASP n 
1 583 GLY n 
1 584 ASP n 
1 585 THR n 
1 586 LEU n 
1 587 LEU n 
1 588 GLN n 
1 589 ARG n 
1 590 LEU n 
1 591 LYS n 
1 592 ASN n 
1 593 ALA n 
1 594 THR n 
1 595 LYS n 
1 596 PRO n 
1 597 SER n 
1 598 ARG n 
1 599 ASP n 
1 600 TRP n 
1 601 GLY n 
1 602 PRO n 
1 603 ALA n 
1 604 LEU n 
1 605 LEU n 
1 606 GLU n 
1 607 HIS n 
1 608 ARG n 
1 609 THR n 
1 610 GLY n 
1 611 ARG n 
1 612 TYR n 
1 613 ALA n 
1 614 PRO n 
1 615 THR n 
1 616 ILE n 
1 617 ALA n 
1 618 PRO n 
1 619 SER n 
1 620 PRO n 
1 621 GLU n 
1 622 ASP n 
1 623 GLY n 
1 624 PHE n 
1 625 GLU n 
1 626 VAL n 
1 627 GLN n 
1 628 PRO n 
1 629 LEU n 
1 630 HIS n 
1 631 PRO n 
1 632 ASP n 
1 633 LYS n 
1 634 ALA n 
1 635 GLN n 
1 636 ILE n 
1 637 PRO n 
1 638 ILE n 
1 639 VAL n 
1 640 GLY n 
1 641 SER n 
1 642 ASN n 
1 643 GLY n 
1 644 SER n 
1 645 SER n 
1 646 ARG n 
1 647 LEU n 
1 648 GLN n 
1 649 ASP n 
1 650 SER n 
1 651 ARG n 
1 652 ILE n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   652 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 SLC6A9 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     9606 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            HEK293F 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CL  non-polymer         . 'CHLORIDE ION'  ? 'Cl -1'          35.453  
CLR non-polymer         . CHOLESTEROL     ? 'C27 H46 O'      386.654 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
NA  non-polymer         . 'SODIUM ION'    ? 'Na 1'           22.990  
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SAR 'peptide linking'   n SARCOSINE       ? 'C3 H7 N O2'     89.093  
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   SER 2   2   ?   ?   ?   A . n 
A 1 3   GLY 3   3   ?   ?   ?   A . n 
A 1 4   GLY 4   4   ?   ?   ?   A . n 
A 1 5   ASP 5   5   ?   ?   ?   A . n 
A 1 6   THR 6   6   ?   ?   ?   A . n 
A 1 7   ARG 7   7   ?   ?   ?   A . n 
A 1 8   ALA 8   8   ?   ?   ?   A . n 
A 1 9   ALA 9   9   ?   ?   ?   A . n 
A 1 10  ILE 10  10  ?   ?   ?   A . n 
A 1 11  ALA 11  11  ?   ?   ?   A . n 
A 1 12  ARG 12  12  ?   ?   ?   A . n 
A 1 13  PRO 13  13  ?   ?   ?   A . n 
A 1 14  ARG 14  14  ?   ?   ?   A . n 
A 1 15  MET 15  15  ?   ?   ?   A . n 
A 1 16  ALA 16  16  ?   ?   ?   A . n 
A 1 17  ALA 17  17  ?   ?   ?   A . n 
A 1 18  ALA 18  18  ?   ?   ?   A . n 
A 1 19  HIS 19  19  ?   ?   ?   A . n 
A 1 20  GLY 20  20  ?   ?   ?   A . n 
A 1 21  PRO 21  21  ?   ?   ?   A . n 
A 1 22  VAL 22  22  ?   ?   ?   A . n 
A 1 23  ALA 23  23  ?   ?   ?   A . n 
A 1 24  PRO 24  24  ?   ?   ?   A . n 
A 1 25  SER 25  25  ?   ?   ?   A . n 
A 1 26  SER 26  26  ?   ?   ?   A . n 
A 1 27  PRO 27  27  ?   ?   ?   A . n 
A 1 28  GLU 28  28  ?   ?   ?   A . n 
A 1 29  GLN 29  29  ?   ?   ?   A . n 
A 1 30  ASN 30  30  ?   ?   ?   A . n 
A 1 31  GLY 31  31  ?   ?   ?   A . n 
A 1 32  ALA 32  32  ?   ?   ?   A . n 
A 1 33  VAL 33  33  ?   ?   ?   A . n 
A 1 34  PRO 34  34  ?   ?   ?   A . n 
A 1 35  SER 35  35  ?   ?   ?   A . n 
A 1 36  GLU 36  36  ?   ?   ?   A . n 
A 1 37  ALA 37  37  ?   ?   ?   A . n 
A 1 38  THR 38  38  ?   ?   ?   A . n 
A 1 39  LYS 39  39  ?   ?   ?   A . n 
A 1 40  ARG 40  40  ?   ?   ?   A . n 
A 1 41  ASP 41  41  ?   ?   ?   A . n 
A 1 42  GLN 42  42  ?   ?   ?   A . n 
A 1 43  ASN 43  43  ?   ?   ?   A . n 
A 1 44  LEU 44  44  ?   ?   ?   A . n 
A 1 45  LYS 45  45  ?   ?   ?   A . n 
A 1 46  ARG 46  46  46  ARG ARG A . n 
A 1 47  GLY 47  47  47  GLY GLY A . n 
A 1 48  ASN 48  48  48  ASN ASN A . n 
A 1 49  TRP 49  49  49  TRP TRP A . n 
A 1 50  GLY 50  50  50  GLY GLY A . n 
A 1 51  ASN 51  51  51  ASN ASN A . n 
A 1 52  GLN 52  52  52  GLN GLN A . n 
A 1 53  ILE 53  53  53  ILE ILE A . n 
A 1 54  GLU 54  54  54  GLU GLU A . n 
A 1 55  PHE 55  55  55  PHE PHE A . n 
A 1 56  VAL 56  56  56  VAL VAL A . n 
A 1 57  LEU 57  57  57  LEU LEU A . n 
A 1 58  THR 58  58  58  THR THR A . n 
A 1 59  SER 59  59  59  SER SER A . n 
A 1 60  VAL 60  60  60  VAL VAL A . n 
A 1 61  GLY 61  61  61  GLY GLY A . n 
A 1 62  TYR 62  62  62  TYR TYR A . n 
A 1 63  ALA 63  63  63  ALA ALA A . n 
A 1 64  VAL 64  64  64  VAL VAL A . n 
A 1 65  GLY 65  65  65  GLY GLY A . n 
A 1 66  LEU 66  66  66  LEU LEU A . n 
A 1 67  GLY 67  67  67  GLY GLY A . n 
A 1 68  ASN 68  68  68  ASN ASN A . n 
A 1 69  VAL 69  69  69  VAL VAL A . n 
A 1 70  TRP 70  70  70  TRP TRP A . n 
A 1 71  ARG 71  71  71  ARG ARG A . n 
A 1 72  PHE 72  72  72  PHE PHE A . n 
A 1 73  PRO 73  73  73  PRO PRO A . n 
A 1 74  TYR 74  74  74  TYR TYR A . n 
A 1 75  LEU 75  75  75  LEU LEU A . n 
A 1 76  CYS 76  76  76  CYS CYS A . n 
A 1 77  TYR 77  77  77  TYR TYR A . n 
A 1 78  ARG 78  78  78  ARG ARG A . n 
A 1 79  ASN 79  79  79  ASN ASN A . n 
A 1 80  GLY 80  80  80  GLY GLY A . n 
A 1 81  GLY 81  81  81  GLY GLY A . n 
A 1 82  GLY 82  82  82  GLY GLY A . n 
A 1 83  ALA 83  83  83  ALA ALA A . n 
A 1 84  PHE 84  84  84  PHE PHE A . n 
A 1 85  MET 85  85  85  MET MET A . n 
A 1 86  PHE 86  86  86  PHE PHE A . n 
A 1 87  PRO 87  87  87  PRO PRO A . n 
A 1 88  TYR 88  88  88  TYR TYR A . n 
A 1 89  PHE 89  89  89  PHE PHE A . n 
A 1 90  ILE 90  90  90  ILE ILE A . n 
A 1 91  MET 91  91  91  MET MET A . n 
A 1 92  LEU 92  92  92  LEU LEU A . n 
A 1 93  ILE 93  93  93  ILE ILE A . n 
A 1 94  PHE 94  94  94  PHE PHE A . n 
A 1 95  CYS 95  95  95  CYS CYS A . n 
A 1 96  GLY 96  96  96  GLY GLY A . n 
A 1 97  ILE 97  97  97  ILE ILE A . n 
A 1 98  PRO 98  98  98  PRO PRO A . n 
A 1 99  LEU 99  99  99  LEU LEU A . n 
A 1 100 PHE 100 100 100 PHE PHE A . n 
A 1 101 PHE 101 101 101 PHE PHE A . n 
A 1 102 MET 102 102 102 MET MET A . n 
A 1 103 GLU 103 103 103 GLU GLU A . n 
A 1 104 LEU 104 104 104 LEU LEU A . n 
A 1 105 SER 105 105 105 SER SER A . n 
A 1 106 PHE 106 106 106 PHE PHE A . n 
A 1 107 GLY 107 107 107 GLY GLY A . n 
A 1 108 GLN 108 108 108 GLN GLN A . n 
A 1 109 PHE 109 109 109 PHE PHE A . n 
A 1 110 ALA 110 110 110 ALA ALA A . n 
A 1 111 SER 111 111 111 SER SER A . n 
A 1 112 GLN 112 112 112 GLN GLN A . n 
A 1 113 GLY 113 113 113 GLY GLY A . n 
A 1 114 CYS 114 114 114 CYS CYS A . n 
A 1 115 LEU 115 115 115 LEU LEU A . n 
A 1 116 GLY 116 116 116 GLY GLY A . n 
A 1 117 VAL 117 117 117 VAL VAL A . n 
A 1 118 TRP 118 118 118 TRP TRP A . n 
A 1 119 ARG 119 119 119 ARG ARG A . n 
A 1 120 ILE 120 120 120 ILE ILE A . n 
A 1 121 SER 121 121 121 SER SER A . n 
A 1 122 PRO 122 122 122 PRO PRO A . n 
A 1 123 MET 123 123 123 MET MET A . n 
A 1 124 PHE 124 124 124 PHE PHE A . n 
A 1 125 LYS 125 125 125 LYS LYS A . n 
A 1 126 GLY 126 126 126 GLY GLY A . n 
A 1 127 VAL 127 127 127 VAL VAL A . n 
A 1 128 GLY 128 128 128 GLY GLY A . n 
A 1 129 TYR 129 129 129 TYR TYR A . n 
A 1 130 GLY 130 130 130 GLY GLY A . n 
A 1 131 MET 131 131 131 MET MET A . n 
A 1 132 MET 132 132 132 MET MET A . n 
A 1 133 VAL 133 133 133 VAL VAL A . n 
A 1 134 VAL 134 134 134 VAL VAL A . n 
A 1 135 SER 135 135 135 SER SER A . n 
A 1 136 THR 136 136 136 THR THR A . n 
A 1 137 TYR 137 137 137 TYR TYR A . n 
A 1 138 ILE 138 138 138 ILE ILE A . n 
A 1 139 GLY 139 139 139 GLY GLY A . n 
A 1 140 ILE 140 140 140 ILE ILE A . n 
A 1 141 TYR 141 141 141 TYR TYR A . n 
A 1 142 TYR 142 142 142 TYR TYR A . n 
A 1 143 ASN 143 143 143 ASN ASN A . n 
A 1 144 VAL 144 144 144 VAL VAL A . n 
A 1 145 VAL 145 145 145 VAL VAL A . n 
A 1 146 ILE 146 146 146 ILE ILE A . n 
A 1 147 CYS 147 147 147 CYS CYS A . n 
A 1 148 ILE 148 148 148 ILE ILE A . n 
A 1 149 ALA 149 149 149 ALA ALA A . n 
A 1 150 PHE 150 150 150 PHE PHE A . n 
A 1 151 TYR 151 151 151 TYR TYR A . n 
A 1 152 TYR 152 152 152 TYR TYR A . n 
A 1 153 PHE 153 153 153 PHE PHE A . n 
A 1 154 PHE 154 154 154 PHE PHE A . n 
A 1 155 SER 155 155 155 SER SER A . n 
A 1 156 SER 156 156 156 SER SER A . n 
A 1 157 MET 157 157 157 MET MET A . n 
A 1 158 THR 158 158 158 THR THR A . n 
A 1 159 HIS 159 159 159 HIS HIS A . n 
A 1 160 VAL 160 160 160 VAL VAL A . n 
A 1 161 LEU 161 161 161 LEU LEU A . n 
A 1 162 PRO 162 162 162 PRO PRO A . n 
A 1 163 TRP 163 163 163 TRP TRP A . n 
A 1 164 ALA 164 164 164 ALA ALA A . n 
A 1 165 TYR 165 165 165 TYR TYR A . n 
A 1 166 CYS 166 166 166 CYS CYS A . n 
A 1 167 ASN 167 167 167 ASN ASN A . n 
A 1 168 ASN 168 168 168 ASN ASN A . n 
A 1 169 PRO 169 169 169 PRO PRO A . n 
A 1 170 TRP 170 170 170 TRP TRP A . n 
A 1 171 ASN 171 171 171 ASN ASN A . n 
A 1 172 THR 172 172 172 THR THR A . n 
A 1 173 HIS 173 173 173 HIS HIS A . n 
A 1 174 ASP 174 174 174 ASP ASP A . n 
A 1 175 CYS 175 175 175 CYS CYS A . n 
A 1 176 ALA 176 176 176 ALA ALA A . n 
A 1 177 GLY 177 177 177 GLY GLY A . n 
A 1 178 VAL 178 178 178 VAL VAL A . n 
A 1 179 LEU 179 179 179 LEU LEU A . n 
A 1 180 ASP 180 180 ?   ?   ?   A . n 
A 1 181 ALA 181 181 ?   ?   ?   A . n 
A 1 182 SER 182 182 ?   ?   ?   A . n 
A 1 183 ASN 183 183 ?   ?   ?   A . n 
A 1 184 LEU 184 184 ?   ?   ?   A . n 
A 1 185 THR 185 185 ?   ?   ?   A . n 
A 1 186 ASN 186 186 ?   ?   ?   A . n 
A 1 187 GLY 187 187 ?   ?   ?   A . n 
A 1 188 SER 188 188 ?   ?   ?   A . n 
A 1 189 ARG 189 189 ?   ?   ?   A . n 
A 1 190 PRO 190 190 ?   ?   ?   A . n 
A 1 191 ALA 191 191 ?   ?   ?   A . n 
A 1 192 ALA 192 192 ?   ?   ?   A . n 
A 1 193 LEU 193 193 ?   ?   ?   A . n 
A 1 194 PRO 194 194 ?   ?   ?   A . n 
A 1 195 SER 195 195 ?   ?   ?   A . n 
A 1 196 ASN 196 196 ?   ?   ?   A . n 
A 1 197 LEU 197 197 ?   ?   ?   A . n 
A 1 198 SER 198 198 ?   ?   ?   A . n 
A 1 199 HIS 199 199 ?   ?   ?   A . n 
A 1 200 LEU 200 200 ?   ?   ?   A . n 
A 1 201 LEU 201 201 ?   ?   ?   A . n 
A 1 202 ASN 202 202 ?   ?   ?   A . n 
A 1 203 HIS 203 203 ?   ?   ?   A . n 
A 1 204 SER 204 204 ?   ?   ?   A . n 
A 1 205 LEU 205 205 ?   ?   ?   A . n 
A 1 206 GLN 206 206 ?   ?   ?   A . n 
A 1 207 ARG 207 207 207 ARG ARG A . n 
A 1 208 THR 208 208 208 THR THR A . n 
A 1 209 SER 209 209 209 SER SER A . n 
A 1 210 PRO 210 210 210 PRO PRO A . n 
A 1 211 SER 211 211 211 SER SER A . n 
A 1 212 GLU 212 212 212 GLU GLU A . n 
A 1 213 GLU 213 213 213 GLU GLU A . n 
A 1 214 TYR 214 214 214 TYR TYR A . n 
A 1 215 TRP 215 215 215 TRP TRP A . n 
A 1 216 ARG 216 216 216 ARG ARG A . n 
A 1 217 LEU 217 217 217 LEU LEU A . n 
A 1 218 TYR 218 218 218 TYR TYR A . n 
A 1 219 VAL 219 219 219 VAL VAL A . n 
A 1 220 LEU 220 220 220 LEU LEU A . n 
A 1 221 LYS 221 221 221 LYS LYS A . n 
A 1 222 LEU 222 222 222 LEU LEU A . n 
A 1 223 SER 223 223 223 SER SER A . n 
A 1 224 ASP 224 224 224 ASP ASP A . n 
A 1 225 ASP 225 225 225 ASP ASP A . n 
A 1 226 ILE 226 226 226 ILE ILE A . n 
A 1 227 GLY 227 227 227 GLY GLY A . n 
A 1 228 ASN 228 228 228 ASN ASN A . n 
A 1 229 PHE 229 229 229 PHE PHE A . n 
A 1 230 GLY 230 230 230 GLY GLY A . n 
A 1 231 GLU 231 231 231 GLU GLU A . n 
A 1 232 VAL 232 232 232 VAL VAL A . n 
A 1 233 ARG 233 233 233 ARG ARG A . n 
A 1 234 LEU 234 234 234 LEU LEU A . n 
A 1 235 PRO 235 235 235 PRO PRO A . n 
A 1 236 LEU 236 236 236 LEU LEU A . n 
A 1 237 LEU 237 237 237 LEU LEU A . n 
A 1 238 GLY 238 238 238 GLY GLY A . n 
A 1 239 CYS 239 239 239 CYS CYS A . n 
A 1 240 LEU 240 240 240 LEU LEU A . n 
A 1 241 GLY 241 241 241 GLY GLY A . n 
A 1 242 VAL 242 242 242 VAL VAL A . n 
A 1 243 SER 243 243 243 SER SER A . n 
A 1 244 TRP 244 244 244 TRP TRP A . n 
A 1 245 LEU 245 245 245 LEU LEU A . n 
A 1 246 VAL 246 246 246 VAL VAL A . n 
A 1 247 VAL 247 247 247 VAL VAL A . n 
A 1 248 PHE 248 248 248 PHE PHE A . n 
A 1 249 LEU 249 249 249 LEU LEU A . n 
A 1 250 CYS 250 250 250 CYS CYS A . n 
A 1 251 LEU 251 251 251 LEU LEU A . n 
A 1 252 ILE 252 252 252 ILE ILE A . n 
A 1 253 ARG 253 253 253 ARG ARG A . n 
A 1 254 GLY 254 254 254 GLY GLY A . n 
A 1 255 VAL 255 255 255 VAL VAL A . n 
A 1 256 LYS 256 256 256 LYS LYS A . n 
A 1 257 SER 257 257 257 SER SER A . n 
A 1 258 SER 258 258 258 SER SER A . n 
A 1 259 GLY 259 259 259 GLY GLY A . n 
A 1 260 LYS 260 260 260 LYS LYS A . n 
A 1 261 VAL 261 261 261 VAL VAL A . n 
A 1 262 VAL 262 262 262 VAL VAL A . n 
A 1 263 TYR 263 263 263 TYR TYR A . n 
A 1 264 PHE 264 264 264 PHE PHE A . n 
A 1 265 THR 265 265 265 THR THR A . n 
A 1 266 ALA 266 266 266 ALA ALA A . n 
A 1 267 THR 267 267 267 THR THR A . n 
A 1 268 PHE 268 268 268 PHE PHE A . n 
A 1 269 PRO 269 269 269 PRO PRO A . n 
A 1 270 TYR 270 270 270 TYR TYR A . n 
A 1 271 VAL 271 271 271 VAL VAL A . n 
A 1 272 VAL 272 272 272 VAL VAL A . n 
A 1 273 LEU 273 273 273 LEU LEU A . n 
A 1 274 THR 274 274 274 THR THR A . n 
A 1 275 ILE 275 275 275 ILE ILE A . n 
A 1 276 LEU 276 276 276 LEU LEU A . n 
A 1 277 PHE 277 277 277 PHE PHE A . n 
A 1 278 VAL 278 278 278 VAL VAL A . n 
A 1 279 ARG 279 279 279 ARG ARG A . n 
A 1 280 GLY 280 280 280 GLY GLY A . n 
A 1 281 VAL 281 281 281 VAL VAL A . n 
A 1 282 THR 282 282 282 THR THR A . n 
A 1 283 LEU 283 283 283 LEU LEU A . n 
A 1 284 GLU 284 284 284 GLU GLU A . n 
A 1 285 GLY 285 285 285 GLY GLY A . n 
A 1 286 ALA 286 286 286 ALA ALA A . n 
A 1 287 PHE 287 287 287 PHE PHE A . n 
A 1 288 ASP 288 288 288 ASP ASP A . n 
A 1 289 GLY 289 289 289 GLY GLY A . n 
A 1 290 ILE 290 290 290 ILE ILE A . n 
A 1 291 MET 291 291 291 MET MET A . n 
A 1 292 TYR 292 292 292 TYR TYR A . n 
A 1 293 TYR 293 293 293 TYR TYR A . n 
A 1 294 LEU 294 294 294 LEU LEU A . n 
A 1 295 THR 295 295 295 THR THR A . n 
A 1 296 PRO 296 296 296 PRO PRO A . n 
A 1 297 GLN 297 297 297 GLN GLN A . n 
A 1 298 TRP 298 298 298 TRP TRP A . n 
A 1 299 ASP 299 299 299 ASP ASP A . n 
A 1 300 LYS 300 300 300 LYS LYS A . n 
A 1 301 ILE 301 301 301 ILE ILE A . n 
A 1 302 LEU 302 302 302 LEU LEU A . n 
A 1 303 GLU 303 303 303 GLU GLU A . n 
A 1 304 ALA 304 304 304 ALA ALA A . n 
A 1 305 LYS 305 305 305 LYS LYS A . n 
A 1 306 VAL 306 306 306 VAL VAL A . n 
A 1 307 TRP 307 307 307 TRP TRP A . n 
A 1 308 GLY 308 308 308 GLY GLY A . n 
A 1 309 ASP 309 309 309 ASP ASP A . n 
A 1 310 ALA 310 310 310 ALA ALA A . n 
A 1 311 ALA 311 311 311 ALA ALA A . n 
A 1 312 SER 312 312 312 SER SER A . n 
A 1 313 GLN 313 313 313 GLN GLN A . n 
A 1 314 ILE 314 314 314 ILE ILE A . n 
A 1 315 PHE 315 315 315 PHE PHE A . n 
A 1 316 TYR 316 316 316 TYR TYR A . n 
A 1 317 SER 317 317 317 SER SER A . n 
A 1 318 LEU 318 318 318 LEU LEU A . n 
A 1 319 GLY 319 319 319 GLY GLY A . n 
A 1 320 CYS 320 320 320 CYS CYS A . n 
A 1 321 ALA 321 321 321 ALA ALA A . n 
A 1 322 TRP 322 322 322 TRP TRP A . n 
A 1 323 GLY 323 323 323 GLY GLY A . n 
A 1 324 GLY 324 324 324 GLY GLY A . n 
A 1 325 LEU 325 325 325 LEU LEU A . n 
A 1 326 ILE 326 326 326 ILE ILE A . n 
A 1 327 THR 327 327 327 THR THR A . n 
A 1 328 MET 328 328 328 MET MET A . n 
A 1 329 ALA 329 329 329 ALA ALA A . n 
A 1 330 SER 330 330 330 SER SER A . n 
A 1 331 TYR 331 331 331 TYR TYR A . n 
A 1 332 ASN 332 332 332 ASN ASN A . n 
A 1 333 LYS 333 333 333 LYS LYS A . n 
A 1 334 PHE 334 334 334 PHE PHE A . n 
A 1 335 HIS 335 335 335 HIS HIS A . n 
A 1 336 ASN 336 336 336 ASN ASN A . n 
A 1 337 ASN 337 337 337 ASN ASN A . n 
A 1 338 CYS 338 338 338 CYS CYS A . n 
A 1 339 TYR 339 339 339 TYR TYR A . n 
A 1 340 ARG 340 340 340 ARG ARG A . n 
A 1 341 ASP 341 341 341 ASP ASP A . n 
A 1 342 SER 342 342 342 SER SER A . n 
A 1 343 VAL 343 343 343 VAL VAL A . n 
A 1 344 ILE 344 344 344 ILE ILE A . n 
A 1 345 ILE 345 345 345 ILE ILE A . n 
A 1 346 SER 346 346 346 SER SER A . n 
A 1 347 ILE 347 347 347 ILE ILE A . n 
A 1 348 THR 348 348 348 THR THR A . n 
A 1 349 ASN 349 349 349 ASN ASN A . n 
A 1 350 CYS 350 350 350 CYS CYS A . n 
A 1 351 ALA 351 351 351 ALA ALA A . n 
A 1 352 THR 352 352 352 THR THR A . n 
A 1 353 SER 353 353 353 SER SER A . n 
A 1 354 VAL 354 354 354 VAL VAL A . n 
A 1 355 TYR 355 355 355 TYR TYR A . n 
A 1 356 ALA 356 356 356 ALA ALA A . n 
A 1 357 GLY 357 357 357 GLY GLY A . n 
A 1 358 PHE 358 358 358 PHE PHE A . n 
A 1 359 VAL 359 359 359 VAL VAL A . n 
A 1 360 ILE 360 360 360 ILE ILE A . n 
A 1 361 PHE 361 361 361 PHE PHE A . n 
A 1 362 SER 362 362 362 SER SER A . n 
A 1 363 ILE 363 363 363 ILE ILE A . n 
A 1 364 LEU 364 364 364 LEU LEU A . n 
A 1 365 GLY 365 365 365 GLY GLY A . n 
A 1 366 PHE 366 366 366 PHE PHE A . n 
A 1 367 MET 367 367 367 MET MET A . n 
A 1 368 ALA 368 368 368 ALA ALA A . n 
A 1 369 ASN 369 369 369 ASN ASN A . n 
A 1 370 HIS 370 370 370 HIS HIS A . n 
A 1 371 LEU 371 371 371 LEU LEU A . n 
A 1 372 GLY 372 372 372 GLY GLY A . n 
A 1 373 VAL 373 373 373 VAL VAL A . n 
A 1 374 ASP 374 374 374 ASP ASP A . n 
A 1 375 VAL 375 375 375 VAL VAL A . n 
A 1 376 SER 376 376 376 SER SER A . n 
A 1 377 ARG 377 377 377 ARG ARG A . n 
A 1 378 VAL 378 378 378 VAL VAL A . n 
A 1 379 ALA 379 379 379 ALA ALA A . n 
A 1 380 ASP 380 380 380 ASP ASP A . n 
A 1 381 HIS 381 381 381 HIS HIS A . n 
A 1 382 GLY 382 382 382 GLY GLY A . n 
A 1 383 PRO 383 383 383 PRO PRO A . n 
A 1 384 GLY 384 384 384 GLY GLY A . n 
A 1 385 LEU 385 385 385 LEU LEU A . n 
A 1 386 ALA 386 386 386 ALA ALA A . n 
A 1 387 PHE 387 387 387 PHE PHE A . n 
A 1 388 VAL 388 388 388 VAL VAL A . n 
A 1 389 ALA 389 389 389 ALA ALA A . n 
A 1 390 TYR 390 390 390 TYR TYR A . n 
A 1 391 PRO 391 391 391 PRO PRO A . n 
A 1 392 GLU 392 392 392 GLU GLU A . n 
A 1 393 ALA 393 393 393 ALA ALA A . n 
A 1 394 LEU 394 394 394 LEU LEU A . n 
A 1 395 THR 395 395 395 THR THR A . n 
A 1 396 LEU 396 396 396 LEU LEU A . n 
A 1 397 LEU 397 397 397 LEU LEU A . n 
A 1 398 PRO 398 398 398 PRO PRO A . n 
A 1 399 ILE 399 399 399 ILE ILE A . n 
A 1 400 SER 400 400 400 SER SER A . n 
A 1 401 PRO 401 401 401 PRO PRO A . n 
A 1 402 LEU 402 402 402 LEU LEU A . n 
A 1 403 TRP 403 403 403 TRP TRP A . n 
A 1 404 SER 404 404 404 SER SER A . n 
A 1 405 LEU 405 405 405 LEU LEU A . n 
A 1 406 LEU 406 406 406 LEU LEU A . n 
A 1 407 PHE 407 407 407 PHE PHE A . n 
A 1 408 PHE 408 408 408 PHE PHE A . n 
A 1 409 PHE 409 409 409 PHE PHE A . n 
A 1 410 MET 410 410 410 MET MET A . n 
A 1 411 LEU 411 411 411 LEU LEU A . n 
A 1 412 ILE 412 412 412 ILE ILE A . n 
A 1 413 LEU 413 413 413 LEU LEU A . n 
A 1 414 LEU 414 414 414 LEU LEU A . n 
A 1 415 GLY 415 415 415 GLY GLY A . n 
A 1 416 LEU 416 416 416 LEU LEU A . n 
A 1 417 GLY 417 417 417 GLY GLY A . n 
A 1 418 THR 418 418 418 THR THR A . n 
A 1 419 GLN 419 419 419 GLN GLN A . n 
A 1 420 PHE 420 420 420 PHE PHE A . n 
A 1 421 CYS 421 421 421 CYS CYS A . n 
A 1 422 LEU 422 422 422 LEU LEU A . n 
A 1 423 LEU 423 423 423 LEU LEU A . n 
A 1 424 GLU 424 424 424 GLU GLU A . n 
A 1 425 THR 425 425 425 THR THR A . n 
A 1 426 LEU 426 426 426 LEU LEU A . n 
A 1 427 VAL 427 427 427 VAL VAL A . n 
A 1 428 THR 428 428 428 THR THR A . n 
A 1 429 ALA 429 429 429 ALA ALA A . n 
A 1 430 ILE 430 430 430 ILE ILE A . n 
A 1 431 VAL 431 431 431 VAL VAL A . n 
A 1 432 ASP 432 432 432 ASP ASP A . n 
A 1 433 GLU 433 433 433 GLU GLU A . n 
A 1 434 VAL 434 434 434 VAL VAL A . n 
A 1 435 GLY 435 435 435 GLY GLY A . n 
A 1 436 ASN 436 436 436 ASN ASN A . n 
A 1 437 GLU 437 437 437 GLU GLU A . n 
A 1 438 TRP 438 438 438 TRP TRP A . n 
A 1 439 ILE 439 439 439 ILE ILE A . n 
A 1 440 LEU 440 440 440 LEU LEU A . n 
A 1 441 GLN 441 441 441 GLN GLN A . n 
A 1 442 LYS 442 442 442 LYS LYS A . n 
A 1 443 LYS 443 443 443 LYS LYS A . n 
A 1 444 THR 444 444 444 THR THR A . n 
A 1 445 TYR 445 445 445 TYR TYR A . n 
A 1 446 VAL 446 446 446 VAL VAL A . n 
A 1 447 THR 447 447 447 THR THR A . n 
A 1 448 LEU 448 448 448 LEU LEU A . n 
A 1 449 GLY 449 449 449 GLY GLY A . n 
A 1 450 VAL 450 450 450 VAL VAL A . n 
A 1 451 ALA 451 451 451 ALA ALA A . n 
A 1 452 VAL 452 452 452 VAL VAL A . n 
A 1 453 ALA 453 453 453 ALA ALA A . n 
A 1 454 GLY 454 454 454 GLY GLY A . n 
A 1 455 PHE 455 455 455 PHE PHE A . n 
A 1 456 LEU 456 456 456 LEU LEU A . n 
A 1 457 LEU 457 457 457 LEU LEU A . n 
A 1 458 GLY 458 458 458 GLY GLY A . n 
A 1 459 ILE 459 459 459 ILE ILE A . n 
A 1 460 PRO 460 460 460 PRO PRO A . n 
A 1 461 LEU 461 461 461 LEU LEU A . n 
A 1 462 THR 462 462 462 THR THR A . n 
A 1 463 SER 463 463 463 SER SER A . n 
A 1 464 GLN 464 464 464 GLN GLN A . n 
A 1 465 ALA 465 465 465 ALA ALA A . n 
A 1 466 GLY 466 466 466 GLY GLY A . n 
A 1 467 ILE 467 467 467 ILE ILE A . n 
A 1 468 TYR 468 468 468 TYR TYR A . n 
A 1 469 TRP 469 469 469 TRP TRP A . n 
A 1 470 LEU 470 470 470 LEU LEU A . n 
A 1 471 LEU 471 471 471 LEU LEU A . n 
A 1 472 LEU 472 472 472 LEU LEU A . n 
A 1 473 MET 473 473 473 MET MET A . n 
A 1 474 ASP 474 474 474 ASP ASP A . n 
A 1 475 ASN 475 475 475 ASN ASN A . n 
A 1 476 TYR 476 476 476 TYR TYR A . n 
A 1 477 ALA 477 477 477 ALA ALA A . n 
A 1 478 ALA 478 478 478 ALA ALA A . n 
A 1 479 SER 479 479 479 SER SER A . n 
A 1 480 PHE 480 480 480 PHE PHE A . n 
A 1 481 SER 481 481 481 SER SER A . n 
A 1 482 LEU 482 482 482 LEU LEU A . n 
A 1 483 VAL 483 483 483 VAL VAL A . n 
A 1 484 VAL 484 484 484 VAL VAL A . n 
A 1 485 ILE 485 485 485 ILE ILE A . n 
A 1 486 SER 486 486 486 SER SER A . n 
A 1 487 CYS 487 487 487 CYS CYS A . n 
A 1 488 ILE 488 488 488 ILE ILE A . n 
A 1 489 MET 489 489 489 MET MET A . n 
A 1 490 CYS 490 490 490 CYS CYS A . n 
A 1 491 VAL 491 491 491 VAL VAL A . n 
A 1 492 ALA 492 492 492 ALA ALA A . n 
A 1 493 ILE 493 493 493 ILE ILE A . n 
A 1 494 MET 494 494 494 MET MET A . n 
A 1 495 TYR 495 495 495 TYR TYR A . n 
A 1 496 ILE 496 496 496 ILE ILE A . n 
A 1 497 TYR 497 497 497 TYR TYR A . n 
A 1 498 GLY 498 498 498 GLY GLY A . n 
A 1 499 HIS 499 499 499 HIS HIS A . n 
A 1 500 ARG 500 500 500 ARG ARG A . n 
A 1 501 ASN 501 501 501 ASN ASN A . n 
A 1 502 TYR 502 502 502 TYR TYR A . n 
A 1 503 PHE 503 503 503 PHE PHE A . n 
A 1 504 GLN 504 504 504 GLN GLN A . n 
A 1 505 ASP 505 505 505 ASP ASP A . n 
A 1 506 ILE 506 506 506 ILE ILE A . n 
A 1 507 GLN 507 507 507 GLN GLN A . n 
A 1 508 MET 508 508 508 MET MET A . n 
A 1 509 MET 509 509 509 MET MET A . n 
A 1 510 LEU 510 510 510 LEU LEU A . n 
A 1 511 GLY 511 511 511 GLY GLY A . n 
A 1 512 PHE 512 512 512 PHE PHE A . n 
A 1 513 PRO 513 513 513 PRO PRO A . n 
A 1 514 PRO 514 514 514 PRO PRO A . n 
A 1 515 PRO 515 515 515 PRO PRO A . n 
A 1 516 LEU 516 516 516 LEU LEU A . n 
A 1 517 PHE 517 517 517 PHE PHE A . n 
A 1 518 PHE 518 518 518 PHE PHE A . n 
A 1 519 GLN 519 519 519 GLN GLN A . n 
A 1 520 ILE 520 520 520 ILE ILE A . n 
A 1 521 CYS 521 521 521 CYS CYS A . n 
A 1 522 TRP 522 522 522 TRP TRP A . n 
A 1 523 ARG 523 523 523 ARG ARG A . n 
A 1 524 PHE 524 524 524 PHE PHE A . n 
A 1 525 VAL 525 525 525 VAL VAL A . n 
A 1 526 SER 526 526 526 SER SER A . n 
A 1 527 PRO 527 527 527 PRO PRO A . n 
A 1 528 ALA 528 528 528 ALA ALA A . n 
A 1 529 ILE 529 529 529 ILE ILE A . n 
A 1 530 ILE 530 530 530 ILE ILE A . n 
A 1 531 PHE 531 531 531 PHE PHE A . n 
A 1 532 PHE 532 532 532 PHE PHE A . n 
A 1 533 ILE 533 533 533 ILE ILE A . n 
A 1 534 LEU 534 534 534 LEU LEU A . n 
A 1 535 VAL 535 535 535 VAL VAL A . n 
A 1 536 PHE 536 536 536 PHE PHE A . n 
A 1 537 THR 537 537 537 THR THR A . n 
A 1 538 VAL 538 538 538 VAL VAL A . n 
A 1 539 ILE 539 539 539 ILE ILE A . n 
A 1 540 GLN 540 540 540 GLN GLN A . n 
A 1 541 TYR 541 541 541 TYR TYR A . n 
A 1 542 GLN 542 542 542 GLN GLN A . n 
A 1 543 PRO 543 543 543 PRO PRO A . n 
A 1 544 ILE 544 544 544 ILE ILE A . n 
A 1 545 THR 545 545 545 THR THR A . n 
A 1 546 TYR 546 546 546 TYR TYR A . n 
A 1 547 ASN 547 547 547 ASN ASN A . n 
A 1 548 HIS 548 548 548 HIS HIS A . n 
A 1 549 TYR 549 549 549 TYR TYR A . n 
A 1 550 GLN 550 550 550 GLN GLN A . n 
A 1 551 TYR 551 551 551 TYR TYR A . n 
A 1 552 PRO 552 552 552 PRO PRO A . n 
A 1 553 GLY 553 553 553 GLY GLY A . n 
A 1 554 TRP 554 554 554 TRP TRP A . n 
A 1 555 ALA 555 555 555 ALA ALA A . n 
A 1 556 VAL 556 556 556 VAL VAL A . n 
A 1 557 ALA 557 557 557 ALA ALA A . n 
A 1 558 ILE 558 558 558 ILE ILE A . n 
A 1 559 GLY 559 559 559 GLY GLY A . n 
A 1 560 PHE 560 560 560 PHE PHE A . n 
A 1 561 LEU 561 561 561 LEU LEU A . n 
A 1 562 MET 562 562 562 MET MET A . n 
A 1 563 ALA 563 563 563 ALA ALA A . n 
A 1 564 LEU 564 564 564 LEU LEU A . n 
A 1 565 SER 565 565 565 SER SER A . n 
A 1 566 SER 566 566 566 SER SER A . n 
A 1 567 VAL 567 567 567 VAL VAL A . n 
A 1 568 LEU 568 568 568 LEU LEU A . n 
A 1 569 CYS 569 569 569 CYS CYS A . n 
A 1 570 ILE 570 570 570 ILE ILE A . n 
A 1 571 PRO 571 571 571 PRO PRO A . n 
A 1 572 LEU 572 572 572 LEU LEU A . n 
A 1 573 TYR 573 573 573 TYR TYR A . n 
A 1 574 ALA 574 574 574 ALA ALA A . n 
A 1 575 MET 575 575 575 MET MET A . n 
A 1 576 PHE 576 576 576 PHE PHE A . n 
A 1 577 ARG 577 577 577 ARG ARG A . n 
A 1 578 LEU 578 578 578 LEU LEU A . n 
A 1 579 CYS 579 579 579 CYS CYS A . n 
A 1 580 ARG 580 580 580 ARG ARG A . n 
A 1 581 THR 581 581 581 THR THR A . n 
A 1 582 ASP 582 582 582 ASP ASP A . n 
A 1 583 GLY 583 583 583 GLY GLY A . n 
A 1 584 ASP 584 584 584 ASP ASP A . n 
A 1 585 THR 585 585 585 THR THR A . n 
A 1 586 LEU 586 586 586 LEU LEU A . n 
A 1 587 LEU 587 587 587 LEU LEU A . n 
A 1 588 GLN 588 588 588 GLN GLN A . n 
A 1 589 ARG 589 589 589 ARG ARG A . n 
A 1 590 LEU 590 590 590 LEU LEU A . n 
A 1 591 LYS 591 591 591 LYS LYS A . n 
A 1 592 ASN 592 592 592 ASN ASN A . n 
A 1 593 ALA 593 593 593 ALA ALA A . n 
A 1 594 THR 594 594 594 THR THR A . n 
A 1 595 LYS 595 595 595 LYS LYS A . n 
A 1 596 PRO 596 596 596 PRO PRO A . n 
A 1 597 SER 597 597 597 SER SER A . n 
A 1 598 ARG 598 598 598 ARG ARG A . n 
A 1 599 ASP 599 599 599 ASP ASP A . n 
A 1 600 TRP 600 600 600 TRP TRP A . n 
A 1 601 GLY 601 601 601 GLY GLY A . n 
A 1 602 PRO 602 602 602 PRO PRO A . n 
A 1 603 ALA 603 603 603 ALA ALA A . n 
A 1 604 LEU 604 604 604 LEU LEU A . n 
A 1 605 LEU 605 605 605 LEU LEU A . n 
A 1 606 GLU 606 606 606 GLU GLU A . n 
A 1 607 HIS 607 607 607 HIS HIS A . n 
A 1 608 ARG 608 608 608 ARG ARG A . n 
A 1 609 THR 609 609 609 THR THR A . n 
A 1 610 GLY 610 610 610 GLY GLY A . n 
A 1 611 ARG 611 611 611 ARG ARG A . n 
A 1 612 TYR 612 612 612 TYR TYR A . n 
A 1 613 ALA 613 613 613 ALA ALA A . n 
A 1 614 PRO 614 614 614 PRO PRO A . n 
A 1 615 THR 615 615 ?   ?   ?   A . n 
A 1 616 ILE 616 616 ?   ?   ?   A . n 
A 1 617 ALA 617 617 ?   ?   ?   A . n 
A 1 618 PRO 618 618 ?   ?   ?   A . n 
A 1 619 SER 619 619 ?   ?   ?   A . n 
A 1 620 PRO 620 620 ?   ?   ?   A . n 
A 1 621 GLU 621 621 ?   ?   ?   A . n 
A 1 622 ASP 622 622 ?   ?   ?   A . n 
A 1 623 GLY 623 623 ?   ?   ?   A . n 
A 1 624 PHE 624 624 ?   ?   ?   A . n 
A 1 625 GLU 625 625 ?   ?   ?   A . n 
A 1 626 VAL 626 626 ?   ?   ?   A . n 
A 1 627 GLN 627 627 ?   ?   ?   A . n 
A 1 628 PRO 628 628 ?   ?   ?   A . n 
A 1 629 LEU 629 629 ?   ?   ?   A . n 
A 1 630 HIS 630 630 ?   ?   ?   A . n 
A 1 631 PRO 631 631 ?   ?   ?   A . n 
A 1 632 ASP 632 632 ?   ?   ?   A . n 
A 1 633 LYS 633 633 ?   ?   ?   A . n 
A 1 634 ALA 634 634 ?   ?   ?   A . n 
A 1 635 GLN 635 635 ?   ?   ?   A . n 
A 1 636 ILE 636 636 ?   ?   ?   A . n 
A 1 637 PRO 637 637 ?   ?   ?   A . n 
A 1 638 ILE 638 638 ?   ?   ?   A . n 
A 1 639 VAL 639 639 ?   ?   ?   A . n 
A 1 640 GLY 640 640 ?   ?   ?   A . n 
A 1 641 SER 641 641 ?   ?   ?   A . n 
A 1 642 ASN 642 642 ?   ?   ?   A . n 
A 1 643 GLY 643 643 ?   ?   ?   A . n 
A 1 644 SER 644 644 ?   ?   ?   A . n 
A 1 645 SER 645 645 ?   ?   ?   A . n 
A 1 646 ARG 646 646 ?   ?   ?   A . n 
A 1 647 LEU 647 647 ?   ?   ?   A . n 
A 1 648 GLN 648 648 ?   ?   ?   A . n 
A 1 649 ASP 649 649 ?   ?   ?   A . n 
A 1 650 SER 650 650 ?   ?   ?   A . n 
A 1 651 ARG 651 651 ?   ?   ?   A . n 
A 1 652 ILE 652 652 ?   ?   ?   A . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 CLR ? ? CLR ? ? 'SUBJECT OF INVESTIGATION' ? 
2 CL  ? ? CL  ? ? 'SUBJECT OF INVESTIGATION' ? 
3 NA  ? ? NA  ? ? 'SUBJECT OF INVESTIGATION' ? 
4 SAR ? ? SAR ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 SAR 1  701 701 SAR SAR A . 
C 3 CLR 1  702 709 CLR CHO A . 
D 3 CLR 1  703 710 CLR CHO A . 
E 3 CLR 1  704 711 CLR CHO A . 
F 4 CL  1  705 1   CL  CL  A . 
G 5 NA  1  706 1   NA  NA  A . 
H 5 NA  1  707 2   NA  NA  A . 
I 6 HOH 1  801 23  HOH HOH A . 
I 6 HOH 2  802 3   HOH HOH A . 
I 6 HOH 3  803 30  HOH HOH A . 
I 6 HOH 4  804 19  HOH HOH A . 
I 6 HOH 5  805 20  HOH HOH A . 
I 6 HOH 6  806 10  HOH HOH A . 
I 6 HOH 7  807 9   HOH HOH A . 
I 6 HOH 8  808 21  HOH HOH A . 
I 6 HOH 9  809 27  HOH HOH A . 
I 6 HOH 10 810 28  HOH HOH A . 
I 6 HOH 11 811 26  HOH HOH A . 
I 6 HOH 12 812 12  HOH HOH A . 
I 6 HOH 13 813 4   HOH HOH A . 
I 6 HOH 14 814 29  HOH HOH A . 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9J8C 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9J8C 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9J8C 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.entry_id                                 9J8C 
_refine.pdbx_diffrn_id                           ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             ? 
_refine.ls_d_res_high                            . 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.B_iso_mean                               ? 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.details                                  ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.overall_SU_ML                            ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.002 ? 4550 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 0.502 ? 6221 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 6.341 ? 619  ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.039 ? 693  ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.004 ? 750  ? f_plane_restr      ? ? 
# 
_struct.entry_id                     9J8C 
_struct.title                        'Human Glycine Transporter 1 in the Sarcosine-Bound State with an Occluded Conformation' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9J8C 
_struct_keywords.text            'human glycine transporter 1, GlyT1, sarcosine, MEMBRANE PROTEIN' 
_struct_keywords.pdbx_keywords   'MEMBRANE PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 3 ? 
E N N 3 ? 
F N N 4 ? 
G N N 5 ? 
H N N 5 ? 
I N N 6 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    SC6A9_HUMAN 
_struct_ref.pdbx_db_accession          P48067 
_struct_ref.pdbx_db_isoform            P48067-3 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MSGGDTRAAIARPRMAAAHGPVAPSSPEQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNG
GGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHV
LPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCL
GVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGC
AWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPIS
PLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASF
SLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGF
LMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVG
SNGSSRLQDSRI
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9J8C 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 652 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P48067 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  652 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       652 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASN A 51  ? VAL A 64  ? ASN A 51  VAL A 64  1 ? 14 
HELX_P HELX_P2  AA2 GLY A 65  ? TRP A 70  ? GLY A 65  TRP A 70  1 ? 6  
HELX_P HELX_P3  AA3 TRP A 70  ? ASN A 79  ? TRP A 70  ASN A 79  1 ? 10 
HELX_P HELX_P4  AA4 GLY A 80  ? ALA A 83  ? GLY A 80  ALA A 83  5 ? 4  
HELX_P HELX_P5  AA5 PHE A 84  ? CYS A 95  ? PHE A 84  CYS A 95  1 ? 12 
HELX_P HELX_P6  AA6 CYS A 95  ? SER A 111 ? CYS A 95  SER A 111 1 ? 17 
HELX_P HELX_P7  AA7 LEU A 115 ? ILE A 120 ? LEU A 115 ILE A 120 5 ? 6  
HELX_P HELX_P8  AA8 SER A 121 ? PHE A 124 ? SER A 121 PHE A 124 5 ? 4  
HELX_P HELX_P9  AA9 LYS A 125 ? SER A 155 ? LYS A 125 SER A 155 1 ? 31 
HELX_P HELX_P10 AB1 SER A 209 ? TYR A 218 ? SER A 209 TYR A 218 1 ? 10 
HELX_P HELX_P11 AB2 ARG A 233 ? ARG A 253 ? ARG A 233 ARG A 253 1 ? 21 
HELX_P HELX_P12 AB3 TYR A 263 ? LEU A 283 ? TYR A 263 LEU A 283 1 ? 21 
HELX_P HELX_P13 AB4 GLY A 285 ? THR A 295 ? GLY A 285 THR A 295 1 ? 11 
HELX_P HELX_P14 AB5 GLU A 303 ? GLY A 319 ? GLU A 303 GLY A 319 1 ? 17 
HELX_P HELX_P15 AB6 GLY A 323 ? SER A 330 ? GLY A 323 SER A 330 1 ? 8  
HELX_P HELX_P16 AB7 ASN A 337 ? GLY A 372 ? ASN A 337 GLY A 372 1 ? 36 
HELX_P HELX_P17 AB8 LEU A 385 ? LEU A 397 ? LEU A 385 LEU A 397 1 ? 13 
HELX_P HELX_P18 AB9 ILE A 399 ? GLY A 435 ? ILE A 399 GLY A 435 1 ? 37 
HELX_P HELX_P19 AC1 LYS A 442 ? GLY A 458 ? LYS A 442 GLY A 458 1 ? 17 
HELX_P HELX_P20 AC2 ILE A 459 ? SER A 463 ? ILE A 459 SER A 463 5 ? 5  
HELX_P HELX_P21 AC3 ALA A 465 ? ALA A 477 ? ALA A 465 ALA A 477 1 ? 13 
HELX_P HELX_P22 AC4 PHE A 480 ? ILE A 496 ? PHE A 480 ILE A 496 1 ? 17 
HELX_P HELX_P23 AC5 GLY A 498 ? GLY A 511 ? GLY A 498 GLY A 511 1 ? 14 
HELX_P HELX_P24 AC6 PRO A 515 ? PHE A 524 ? PRO A 515 PHE A 524 1 ? 10 
HELX_P HELX_P25 AC7 PHE A 524 ? GLN A 540 ? PHE A 524 GLN A 540 1 ? 17 
HELX_P HELX_P26 AC8 PRO A 552 ? LEU A 568 ? PRO A 552 LEU A 568 1 ? 17 
HELX_P HELX_P27 AC9 LEU A 568 ? CYS A 579 ? LEU A 568 CYS A 579 1 ? 12 
HELX_P HELX_P28 AD1 THR A 585 ? ALA A 593 ? THR A 585 ALA A 593 1 ? 9  
HELX_P HELX_P29 AD2 LEU A 604 ? ARG A 608 ? LEU A 604 ARG A 608 5 ? 5  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? A CYS 166 SG  ? ? ? 1_555 A CYS 175 SG ? ? A CYS 166 A CYS 175 1_555 ? ? ? ? ? ? ? 2.031 ? ? 
metalc1 metalc ? ? A GLY 61  O   ? ? ? 1_555 H NA  .   NA ? ? A GLY 61  A NA  707 1_555 ? ? ? ? ? ? ? 2.649 ? ? 
metalc2 metalc ? ? A ALA 63  O   ? ? ? 1_555 G NA  .   NA ? ? A ALA 63  A NA  706 1_555 ? ? ? ? ? ? ? 2.311 ? ? 
metalc3 metalc ? ? A VAL 64  O   ? ? ? 1_555 H NA  .   NA ? ? A VAL 64  A NA  707 1_555 ? ? ? ? ? ? ? 2.364 ? ? 
metalc4 metalc ? ? A ASN 68  OD1 ? ? ? 1_555 G NA  .   NA ? ? A ASN 68  A NA  706 1_555 ? ? ? ? ? ? ? 2.297 ? ? 
metalc5 metalc ? ? A SER 317 O   ? ? ? 1_555 G NA  .   NA ? ? A SER 317 A NA  706 1_555 ? ? ? ? ? ? ? 2.377 ? ? 
metalc6 metalc ? ? A SER 317 OG  ? ? ? 1_555 G NA  .   NA ? ? A SER 317 A NA  706 1_555 ? ? ? ? ? ? ? 2.536 ? ? 
metalc7 metalc ? ? A LEU 414 O   ? ? ? 1_555 H NA  .   NA ? ? A LEU 414 A NA  707 1_555 ? ? ? ? ? ? ? 2.414 ? ? 
metalc8 metalc ? ? A THR 418 OG1 ? ? ? 1_555 H NA  .   NA ? ? A THR 418 A NA  707 1_555 ? ? ? ? ? ? ? 2.802 ? ? 
metalc9 metalc ? ? B SAR .   O   ? ? ? 1_555 G NA  .   NA ? ? A SAR 701 A NA  706 1_555 ? ? ? ? ? ? ? 2.644 ? ? 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
metalc ? ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  O   ? A GLY 61  ? A GLY 61  ? 1_555 NA ? H NA . ? A NA 707 ? 1_555 O   ? A VAL 64  ? A VAL 64  ? 1_555 81.2  ? 
2  O   ? A GLY 61  ? A GLY 61  ? 1_555 NA ? H NA . ? A NA 707 ? 1_555 O   ? A LEU 414 ? A LEU 414 ? 1_555 155.7 ? 
3  O   ? A VAL 64  ? A VAL 64  ? 1_555 NA ? H NA . ? A NA 707 ? 1_555 O   ? A LEU 414 ? A LEU 414 ? 1_555 119.6 ? 
4  O   ? A GLY 61  ? A GLY 61  ? 1_555 NA ? H NA . ? A NA 707 ? 1_555 OG1 ? A THR 418 ? A THR 418 ? 1_555 95.8  ? 
5  O   ? A VAL 64  ? A VAL 64  ? 1_555 NA ? H NA . ? A NA 707 ? 1_555 OG1 ? A THR 418 ? A THR 418 ? 1_555 96.2  ? 
6  O   ? A LEU 414 ? A LEU 414 ? 1_555 NA ? H NA . ? A NA 707 ? 1_555 OG1 ? A THR 418 ? A THR 418 ? 1_555 94.2  ? 
7  O   ? A ALA 63  ? A ALA 63  ? 1_555 NA ? G NA . ? A NA 706 ? 1_555 OD1 ? A ASN 68  ? A ASN 68  ? 1_555 115.8 ? 
8  O   ? A ALA 63  ? A ALA 63  ? 1_555 NA ? G NA . ? A NA 706 ? 1_555 O   ? A SER 317 ? A SER 317 ? 1_555 84.8  ? 
9  OD1 ? A ASN 68  ? A ASN 68  ? 1_555 NA ? G NA . ? A NA 706 ? 1_555 O   ? A SER 317 ? A SER 317 ? 1_555 159.2 ? 
10 O   ? A ALA 63  ? A ALA 63  ? 1_555 NA ? G NA . ? A NA 706 ? 1_555 OG  ? A SER 317 ? A SER 317 ? 1_555 156.6 ? 
11 OD1 ? A ASN 68  ? A ASN 68  ? 1_555 NA ? G NA . ? A NA 706 ? 1_555 OG  ? A SER 317 ? A SER 317 ? 1_555 84.6  ? 
12 O   ? A SER 317 ? A SER 317 ? 1_555 NA ? G NA . ? A NA 706 ? 1_555 OG  ? A SER 317 ? A SER 317 ? 1_555 75.9  ? 
13 O   ? A ALA 63  ? A ALA 63  ? 1_555 NA ? G NA . ? A NA 706 ? 1_555 O   ? B SAR .   ? A SAR 701 ? 1_555 75.2  ? 
14 OD1 ? A ASN 68  ? A ASN 68  ? 1_555 NA ? G NA . ? A NA 706 ? 1_555 O   ? B SAR .   ? A SAR 701 ? 1_555 94.2  ? 
15 O   ? A SER 317 ? A SER 317 ? 1_555 NA ? G NA . ? A NA 706 ? 1_555 O   ? B SAR .   ? A SAR 701 ? 1_555 88.3  ? 
16 OG  ? A SER 317 ? A SER 317 ? 1_555 NA ? G NA . ? A NA 706 ? 1_555 O   ? B SAR .   ? A SAR 701 ? 1_555 116.7 ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      CYS 
_pdbx_modification_feature.label_asym_id                      A 
_pdbx_modification_feature.label_seq_id                       166 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      175 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       CYS 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        166 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       175 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               SG 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                . 
_pdbx_modification_feature.ref_pcm_id                         . 
_pdbx_modification_feature.ref_comp_id                        . 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Disulfide bridge' 
# 
_pdbx_entry_details.entry_id                   9J8C 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 LYS A 260 ? ? -119.63 -166.75 
2 1 ILE A 399 ? ? 55.30   70.74   
3 1 TYR A 476 ? ? -130.89 -38.09  
4 1 HIS A 548 ? ? 67.22   -5.53   
5 1 TYR A 549 ? ? -140.42 10.62   
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9J8C 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    9J8C 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  2.9 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               639501 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.5 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'human glycine transporter 1 (GlyT1)' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        9J8C 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             1200 
_em_imaging.nominal_defocus_max             2200 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              9J8C 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              100 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9J8C 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A MET 1   ? A MET 1   
2   1 Y 1 A SER 2   ? A SER 2   
3   1 Y 1 A GLY 3   ? A GLY 3   
4   1 Y 1 A GLY 4   ? A GLY 4   
5   1 Y 1 A ASP 5   ? A ASP 5   
6   1 Y 1 A THR 6   ? A THR 6   
7   1 Y 1 A ARG 7   ? A ARG 7   
8   1 Y 1 A ALA 8   ? A ALA 8   
9   1 Y 1 A ALA 9   ? A ALA 9   
10  1 Y 1 A ILE 10  ? A ILE 10  
11  1 Y 1 A ALA 11  ? A ALA 11  
12  1 Y 1 A ARG 12  ? A ARG 12  
13  1 Y 1 A PRO 13  ? A PRO 13  
14  1 Y 1 A ARG 14  ? A ARG 14  
15  1 Y 1 A MET 15  ? A MET 15  
16  1 Y 1 A ALA 16  ? A ALA 16  
17  1 Y 1 A ALA 17  ? A ALA 17  
18  1 Y 1 A ALA 18  ? A ALA 18  
19  1 Y 1 A HIS 19  ? A HIS 19  
20  1 Y 1 A GLY 20  ? A GLY 20  
21  1 Y 1 A PRO 21  ? A PRO 21  
22  1 Y 1 A VAL 22  ? A VAL 22  
23  1 Y 1 A ALA 23  ? A ALA 23  
24  1 Y 1 A PRO 24  ? A PRO 24  
25  1 Y 1 A SER 25  ? A SER 25  
26  1 Y 1 A SER 26  ? A SER 26  
27  1 Y 1 A PRO 27  ? A PRO 27  
28  1 Y 1 A GLU 28  ? A GLU 28  
29  1 Y 1 A GLN 29  ? A GLN 29  
30  1 Y 1 A ASN 30  ? A ASN 30  
31  1 Y 1 A GLY 31  ? A GLY 31  
32  1 Y 1 A ALA 32  ? A ALA 32  
33  1 Y 1 A VAL 33  ? A VAL 33  
34  1 Y 1 A PRO 34  ? A PRO 34  
35  1 Y 1 A SER 35  ? A SER 35  
36  1 Y 1 A GLU 36  ? A GLU 36  
37  1 Y 1 A ALA 37  ? A ALA 37  
38  1 Y 1 A THR 38  ? A THR 38  
39  1 Y 1 A LYS 39  ? A LYS 39  
40  1 Y 1 A ARG 40  ? A ARG 40  
41  1 Y 1 A ASP 41  ? A ASP 41  
42  1 Y 1 A GLN 42  ? A GLN 42  
43  1 Y 1 A ASN 43  ? A ASN 43  
44  1 Y 1 A LEU 44  ? A LEU 44  
45  1 Y 1 A LYS 45  ? A LYS 45  
46  1 Y 1 A ASP 180 ? A ASP 180 
47  1 Y 1 A ALA 181 ? A ALA 181 
48  1 Y 1 A SER 182 ? A SER 182 
49  1 Y 1 A ASN 183 ? A ASN 183 
50  1 Y 1 A LEU 184 ? A LEU 184 
51  1 Y 1 A THR 185 ? A THR 185 
52  1 Y 1 A ASN 186 ? A ASN 186 
53  1 Y 1 A GLY 187 ? A GLY 187 
54  1 Y 1 A SER 188 ? A SER 188 
55  1 Y 1 A ARG 189 ? A ARG 189 
56  1 Y 1 A PRO 190 ? A PRO 190 
57  1 Y 1 A ALA 191 ? A ALA 191 
58  1 Y 1 A ALA 192 ? A ALA 192 
59  1 Y 1 A LEU 193 ? A LEU 193 
60  1 Y 1 A PRO 194 ? A PRO 194 
61  1 Y 1 A SER 195 ? A SER 195 
62  1 Y 1 A ASN 196 ? A ASN 196 
63  1 Y 1 A LEU 197 ? A LEU 197 
64  1 Y 1 A SER 198 ? A SER 198 
65  1 Y 1 A HIS 199 ? A HIS 199 
66  1 Y 1 A LEU 200 ? A LEU 200 
67  1 Y 1 A LEU 201 ? A LEU 201 
68  1 Y 1 A ASN 202 ? A ASN 202 
69  1 Y 1 A HIS 203 ? A HIS 203 
70  1 Y 1 A SER 204 ? A SER 204 
71  1 Y 1 A LEU 205 ? A LEU 205 
72  1 Y 1 A GLN 206 ? A GLN 206 
73  1 Y 1 A THR 615 ? A THR 615 
74  1 Y 1 A ILE 616 ? A ILE 616 
75  1 Y 1 A ALA 617 ? A ALA 617 
76  1 Y 1 A PRO 618 ? A PRO 618 
77  1 Y 1 A SER 619 ? A SER 619 
78  1 Y 1 A PRO 620 ? A PRO 620 
79  1 Y 1 A GLU 621 ? A GLU 621 
80  1 Y 1 A ASP 622 ? A ASP 622 
81  1 Y 1 A GLY 623 ? A GLY 623 
82  1 Y 1 A PHE 624 ? A PHE 624 
83  1 Y 1 A GLU 625 ? A GLU 625 
84  1 Y 1 A VAL 626 ? A VAL 626 
85  1 Y 1 A GLN 627 ? A GLN 627 
86  1 Y 1 A PRO 628 ? A PRO 628 
87  1 Y 1 A LEU 629 ? A LEU 629 
88  1 Y 1 A HIS 630 ? A HIS 630 
89  1 Y 1 A PRO 631 ? A PRO 631 
90  1 Y 1 A ASP 632 ? A ASP 632 
91  1 Y 1 A LYS 633 ? A LYS 633 
92  1 Y 1 A ALA 634 ? A ALA 634 
93  1 Y 1 A GLN 635 ? A GLN 635 
94  1 Y 1 A ILE 636 ? A ILE 636 
95  1 Y 1 A PRO 637 ? A PRO 637 
96  1 Y 1 A ILE 638 ? A ILE 638 
97  1 Y 1 A VAL 639 ? A VAL 639 
98  1 Y 1 A GLY 640 ? A GLY 640 
99  1 Y 1 A SER 641 ? A SER 641 
100 1 Y 1 A ASN 642 ? A ASN 642 
101 1 Y 1 A GLY 643 ? A GLY 643 
102 1 Y 1 A SER 644 ? A SER 644 
103 1 Y 1 A SER 645 ? A SER 645 
104 1 Y 1 A ARG 646 ? A ARG 646 
105 1 Y 1 A LEU 647 ? A LEU 647 
106 1 Y 1 A GLN 648 ? A GLN 648 
107 1 Y 1 A ASP 649 ? A ASP 649 
108 1 Y 1 A SER 650 ? A SER 650 
109 1 Y 1 A ARG 651 ? A ARG 651 
110 1 Y 1 A ILE 652 ? A ILE 652 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CL  CL   CL N N 74  
CLR C1   C  N N 75  
CLR C2   C  N N 76  
CLR C3   C  N S 77  
CLR C4   C  N N 78  
CLR C5   C  N N 79  
CLR C6   C  N N 80  
CLR C7   C  N N 81  
CLR C8   C  N S 82  
CLR C9   C  N S 83  
CLR C10  C  N R 84  
CLR C11  C  N N 85  
CLR C12  C  N N 86  
CLR C13  C  N R 87  
CLR C14  C  N S 88  
CLR C15  C  N N 89  
CLR C16  C  N N 90  
CLR C17  C  N R 91  
CLR C18  C  N N 92  
CLR C19  C  N N 93  
CLR C20  C  N R 94  
CLR C21  C  N N 95  
CLR C22  C  N N 96  
CLR C23  C  N N 97  
CLR C24  C  N N 98  
CLR C25  C  N N 99  
CLR C26  C  N N 100 
CLR C27  C  N N 101 
CLR O1   O  N N 102 
CLR H11  H  N N 103 
CLR H12  H  N N 104 
CLR H21  H  N N 105 
CLR H22  H  N N 106 
CLR H3   H  N N 107 
CLR H41  H  N N 108 
CLR H42  H  N N 109 
CLR H6   H  N N 110 
CLR H71  H  N N 111 
CLR H72  H  N N 112 
CLR H8   H  N N 113 
CLR H9   H  N N 114 
CLR H111 H  N N 115 
CLR H112 H  N N 116 
CLR H121 H  N N 117 
CLR H122 H  N N 118 
CLR H14  H  N N 119 
CLR H151 H  N N 120 
CLR H152 H  N N 121 
CLR H161 H  N N 122 
CLR H162 H  N N 123 
CLR H17  H  N N 124 
CLR H181 H  N N 125 
CLR H182 H  N N 126 
CLR H183 H  N N 127 
CLR H191 H  N N 128 
CLR H192 H  N N 129 
CLR H193 H  N N 130 
CLR H20  H  N N 131 
CLR H211 H  N N 132 
CLR H212 H  N N 133 
CLR H213 H  N N 134 
CLR H221 H  N N 135 
CLR H222 H  N N 136 
CLR H231 H  N N 137 
CLR H232 H  N N 138 
CLR H241 H  N N 139 
CLR H242 H  N N 140 
CLR H25  H  N N 141 
CLR H261 H  N N 142 
CLR H262 H  N N 143 
CLR H263 H  N N 144 
CLR H271 H  N N 145 
CLR H272 H  N N 146 
CLR H273 H  N N 147 
CLR H1   H  N N 148 
CYS N    N  N N 149 
CYS CA   C  N R 150 
CYS C    C  N N 151 
CYS O    O  N N 152 
CYS CB   C  N N 153 
CYS SG   S  N N 154 
CYS OXT  O  N N 155 
CYS H    H  N N 156 
CYS H2   H  N N 157 
CYS HA   H  N N 158 
CYS HB2  H  N N 159 
CYS HB3  H  N N 160 
CYS HG   H  N N 161 
CYS HXT  H  N N 162 
GLN N    N  N N 163 
GLN CA   C  N S 164 
GLN C    C  N N 165 
GLN O    O  N N 166 
GLN CB   C  N N 167 
GLN CG   C  N N 168 
GLN CD   C  N N 169 
GLN OE1  O  N N 170 
GLN NE2  N  N N 171 
GLN OXT  O  N N 172 
GLN H    H  N N 173 
GLN H2   H  N N 174 
GLN HA   H  N N 175 
GLN HB2  H  N N 176 
GLN HB3  H  N N 177 
GLN HG2  H  N N 178 
GLN HG3  H  N N 179 
GLN HE21 H  N N 180 
GLN HE22 H  N N 181 
GLN HXT  H  N N 182 
GLU N    N  N N 183 
GLU CA   C  N S 184 
GLU C    C  N N 185 
GLU O    O  N N 186 
GLU CB   C  N N 187 
GLU CG   C  N N 188 
GLU CD   C  N N 189 
GLU OE1  O  N N 190 
GLU OE2  O  N N 191 
GLU OXT  O  N N 192 
GLU H    H  N N 193 
GLU H2   H  N N 194 
GLU HA   H  N N 195 
GLU HB2  H  N N 196 
GLU HB3  H  N N 197 
GLU HG2  H  N N 198 
GLU HG3  H  N N 199 
GLU HE2  H  N N 200 
GLU HXT  H  N N 201 
GLY N    N  N N 202 
GLY CA   C  N N 203 
GLY C    C  N N 204 
GLY O    O  N N 205 
GLY OXT  O  N N 206 
GLY H    H  N N 207 
GLY H2   H  N N 208 
GLY HA2  H  N N 209 
GLY HA3  H  N N 210 
GLY HXT  H  N N 211 
HIS N    N  N N 212 
HIS CA   C  N S 213 
HIS C    C  N N 214 
HIS O    O  N N 215 
HIS CB   C  N N 216 
HIS CG   C  Y N 217 
HIS ND1  N  Y N 218 
HIS CD2  C  Y N 219 
HIS CE1  C  Y N 220 
HIS NE2  N  Y N 221 
HIS OXT  O  N N 222 
HIS H    H  N N 223 
HIS H2   H  N N 224 
HIS HA   H  N N 225 
HIS HB2  H  N N 226 
HIS HB3  H  N N 227 
HIS HD1  H  N N 228 
HIS HD2  H  N N 229 
HIS HE1  H  N N 230 
HIS HE2  H  N N 231 
HIS HXT  H  N N 232 
HOH O    O  N N 233 
HOH H1   H  N N 234 
HOH H2   H  N N 235 
ILE N    N  N N 236 
ILE CA   C  N S 237 
ILE C    C  N N 238 
ILE O    O  N N 239 
ILE CB   C  N S 240 
ILE CG1  C  N N 241 
ILE CG2  C  N N 242 
ILE CD1  C  N N 243 
ILE OXT  O  N N 244 
ILE H    H  N N 245 
ILE H2   H  N N 246 
ILE HA   H  N N 247 
ILE HB   H  N N 248 
ILE HG12 H  N N 249 
ILE HG13 H  N N 250 
ILE HG21 H  N N 251 
ILE HG22 H  N N 252 
ILE HG23 H  N N 253 
ILE HD11 H  N N 254 
ILE HD12 H  N N 255 
ILE HD13 H  N N 256 
ILE HXT  H  N N 257 
LEU N    N  N N 258 
LEU CA   C  N S 259 
LEU C    C  N N 260 
LEU O    O  N N 261 
LEU CB   C  N N 262 
LEU CG   C  N N 263 
LEU CD1  C  N N 264 
LEU CD2  C  N N 265 
LEU OXT  O  N N 266 
LEU H    H  N N 267 
LEU H2   H  N N 268 
LEU HA   H  N N 269 
LEU HB2  H  N N 270 
LEU HB3  H  N N 271 
LEU HG   H  N N 272 
LEU HD11 H  N N 273 
LEU HD12 H  N N 274 
LEU HD13 H  N N 275 
LEU HD21 H  N N 276 
LEU HD22 H  N N 277 
LEU HD23 H  N N 278 
LEU HXT  H  N N 279 
LYS N    N  N N 280 
LYS CA   C  N S 281 
LYS C    C  N N 282 
LYS O    O  N N 283 
LYS CB   C  N N 284 
LYS CG   C  N N 285 
LYS CD   C  N N 286 
LYS CE   C  N N 287 
LYS NZ   N  N N 288 
LYS OXT  O  N N 289 
LYS H    H  N N 290 
LYS H2   H  N N 291 
LYS HA   H  N N 292 
LYS HB2  H  N N 293 
LYS HB3  H  N N 294 
LYS HG2  H  N N 295 
LYS HG3  H  N N 296 
LYS HD2  H  N N 297 
LYS HD3  H  N N 298 
LYS HE2  H  N N 299 
LYS HE3  H  N N 300 
LYS HZ1  H  N N 301 
LYS HZ2  H  N N 302 
LYS HZ3  H  N N 303 
LYS HXT  H  N N 304 
MET N    N  N N 305 
MET CA   C  N S 306 
MET C    C  N N 307 
MET O    O  N N 308 
MET CB   C  N N 309 
MET CG   C  N N 310 
MET SD   S  N N 311 
MET CE   C  N N 312 
MET OXT  O  N N 313 
MET H    H  N N 314 
MET H2   H  N N 315 
MET HA   H  N N 316 
MET HB2  H  N N 317 
MET HB3  H  N N 318 
MET HG2  H  N N 319 
MET HG3  H  N N 320 
MET HE1  H  N N 321 
MET HE2  H  N N 322 
MET HE3  H  N N 323 
MET HXT  H  N N 324 
NA  NA   NA N N 325 
PHE N    N  N N 326 
PHE CA   C  N S 327 
PHE C    C  N N 328 
PHE O    O  N N 329 
PHE CB   C  N N 330 
PHE CG   C  Y N 331 
PHE CD1  C  Y N 332 
PHE CD2  C  Y N 333 
PHE CE1  C  Y N 334 
PHE CE2  C  Y N 335 
PHE CZ   C  Y N 336 
PHE OXT  O  N N 337 
PHE H    H  N N 338 
PHE H2   H  N N 339 
PHE HA   H  N N 340 
PHE HB2  H  N N 341 
PHE HB3  H  N N 342 
PHE HD1  H  N N 343 
PHE HD2  H  N N 344 
PHE HE1  H  N N 345 
PHE HE2  H  N N 346 
PHE HZ   H  N N 347 
PHE HXT  H  N N 348 
PRO N    N  N N 349 
PRO CA   C  N S 350 
PRO C    C  N N 351 
PRO O    O  N N 352 
PRO CB   C  N N 353 
PRO CG   C  N N 354 
PRO CD   C  N N 355 
PRO OXT  O  N N 356 
PRO H    H  N N 357 
PRO HA   H  N N 358 
PRO HB2  H  N N 359 
PRO HB3  H  N N 360 
PRO HG2  H  N N 361 
PRO HG3  H  N N 362 
PRO HD2  H  N N 363 
PRO HD3  H  N N 364 
PRO HXT  H  N N 365 
SAR N    N  N N 366 
SAR CA   C  N N 367 
SAR C    C  N N 368 
SAR O    O  N N 369 
SAR CN   C  N N 370 
SAR OXT  O  N N 371 
SAR H    H  N N 372 
SAR HA2  H  N N 373 
SAR HA3  H  N N 374 
SAR HN1  H  N N 375 
SAR HN2  H  N N 376 
SAR HN3  H  N N 377 
SAR HXT  H  N N 378 
SER N    N  N N 379 
SER CA   C  N S 380 
SER C    C  N N 381 
SER O    O  N N 382 
SER CB   C  N N 383 
SER OG   O  N N 384 
SER OXT  O  N N 385 
SER H    H  N N 386 
SER H2   H  N N 387 
SER HA   H  N N 388 
SER HB2  H  N N 389 
SER HB3  H  N N 390 
SER HG   H  N N 391 
SER HXT  H  N N 392 
THR N    N  N N 393 
THR CA   C  N S 394 
THR C    C  N N 395 
THR O    O  N N 396 
THR CB   C  N R 397 
THR OG1  O  N N 398 
THR CG2  C  N N 399 
THR OXT  O  N N 400 
THR H    H  N N 401 
THR H2   H  N N 402 
THR HA   H  N N 403 
THR HB   H  N N 404 
THR HG1  H  N N 405 
THR HG21 H  N N 406 
THR HG22 H  N N 407 
THR HG23 H  N N 408 
THR HXT  H  N N 409 
TRP N    N  N N 410 
TRP CA   C  N S 411 
TRP C    C  N N 412 
TRP O    O  N N 413 
TRP CB   C  N N 414 
TRP CG   C  Y N 415 
TRP CD1  C  Y N 416 
TRP CD2  C  Y N 417 
TRP NE1  N  Y N 418 
TRP CE2  C  Y N 419 
TRP CE3  C  Y N 420 
TRP CZ2  C  Y N 421 
TRP CZ3  C  Y N 422 
TRP CH2  C  Y N 423 
TRP OXT  O  N N 424 
TRP H    H  N N 425 
TRP H2   H  N N 426 
TRP HA   H  N N 427 
TRP HB2  H  N N 428 
TRP HB3  H  N N 429 
TRP HD1  H  N N 430 
TRP HE1  H  N N 431 
TRP HE3  H  N N 432 
TRP HZ2  H  N N 433 
TRP HZ3  H  N N 434 
TRP HH2  H  N N 435 
TRP HXT  H  N N 436 
TYR N    N  N N 437 
TYR CA   C  N S 438 
TYR C    C  N N 439 
TYR O    O  N N 440 
TYR CB   C  N N 441 
TYR CG   C  Y N 442 
TYR CD1  C  Y N 443 
TYR CD2  C  Y N 444 
TYR CE1  C  Y N 445 
TYR CE2  C  Y N 446 
TYR CZ   C  Y N 447 
TYR OH   O  N N 448 
TYR OXT  O  N N 449 
TYR H    H  N N 450 
TYR H2   H  N N 451 
TYR HA   H  N N 452 
TYR HB2  H  N N 453 
TYR HB3  H  N N 454 
TYR HD1  H  N N 455 
TYR HD2  H  N N 456 
TYR HE1  H  N N 457 
TYR HE2  H  N N 458 
TYR HH   H  N N 459 
TYR HXT  H  N N 460 
VAL N    N  N N 461 
VAL CA   C  N S 462 
VAL C    C  N N 463 
VAL O    O  N N 464 
VAL CB   C  N N 465 
VAL CG1  C  N N 466 
VAL CG2  C  N N 467 
VAL OXT  O  N N 468 
VAL H    H  N N 469 
VAL H2   H  N N 470 
VAL HA   H  N N 471 
VAL HB   H  N N 472 
VAL HG11 H  N N 473 
VAL HG12 H  N N 474 
VAL HG13 H  N N 475 
VAL HG21 H  N N 476 
VAL HG22 H  N N 477 
VAL HG23 H  N N 478 
VAL HXT  H  N N 479 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CLR C1  C2   sing N N 70  
CLR C1  C10  sing N N 71  
CLR C1  H11  sing N N 72  
CLR C1  H12  sing N N 73  
CLR C2  C3   sing N N 74  
CLR C2  H21  sing N N 75  
CLR C2  H22  sing N N 76  
CLR C3  C4   sing N N 77  
CLR C3  O1   sing N N 78  
CLR C3  H3   sing N N 79  
CLR C4  C5   sing N N 80  
CLR C4  H41  sing N N 81  
CLR C4  H42  sing N N 82  
CLR C5  C6   doub N N 83  
CLR C5  C10  sing N N 84  
CLR C6  C7   sing N N 85  
CLR C6  H6   sing N N 86  
CLR C7  C8   sing N N 87  
CLR C7  H71  sing N N 88  
CLR C7  H72  sing N N 89  
CLR C8  C9   sing N N 90  
CLR C8  C14  sing N N 91  
CLR C8  H8   sing N N 92  
CLR C9  C10  sing N N 93  
CLR C9  C11  sing N N 94  
CLR C9  H9   sing N N 95  
CLR C10 C19  sing N N 96  
CLR C11 C12  sing N N 97  
CLR C11 H111 sing N N 98  
CLR C11 H112 sing N N 99  
CLR C12 C13  sing N N 100 
CLR C12 H121 sing N N 101 
CLR C12 H122 sing N N 102 
CLR C13 C14  sing N N 103 
CLR C13 C17  sing N N 104 
CLR C13 C18  sing N N 105 
CLR C14 C15  sing N N 106 
CLR C14 H14  sing N N 107 
CLR C15 C16  sing N N 108 
CLR C15 H151 sing N N 109 
CLR C15 H152 sing N N 110 
CLR C16 C17  sing N N 111 
CLR C16 H161 sing N N 112 
CLR C16 H162 sing N N 113 
CLR C17 C20  sing N N 114 
CLR C17 H17  sing N N 115 
CLR C18 H181 sing N N 116 
CLR C18 H182 sing N N 117 
CLR C18 H183 sing N N 118 
CLR C19 H191 sing N N 119 
CLR C19 H192 sing N N 120 
CLR C19 H193 sing N N 121 
CLR C20 C21  sing N N 122 
CLR C20 C22  sing N N 123 
CLR C20 H20  sing N N 124 
CLR C21 H211 sing N N 125 
CLR C21 H212 sing N N 126 
CLR C21 H213 sing N N 127 
CLR C22 C23  sing N N 128 
CLR C22 H221 sing N N 129 
CLR C22 H222 sing N N 130 
CLR C23 C24  sing N N 131 
CLR C23 H231 sing N N 132 
CLR C23 H232 sing N N 133 
CLR C24 C25  sing N N 134 
CLR C24 H241 sing N N 135 
CLR C24 H242 sing N N 136 
CLR C25 C26  sing N N 137 
CLR C25 C27  sing N N 138 
CLR C25 H25  sing N N 139 
CLR C26 H261 sing N N 140 
CLR C26 H262 sing N N 141 
CLR C26 H263 sing N N 142 
CLR C27 H271 sing N N 143 
CLR C27 H272 sing N N 144 
CLR C27 H273 sing N N 145 
CLR O1  H1   sing N N 146 
CYS N   CA   sing N N 147 
CYS N   H    sing N N 148 
CYS N   H2   sing N N 149 
CYS CA  C    sing N N 150 
CYS CA  CB   sing N N 151 
CYS CA  HA   sing N N 152 
CYS C   O    doub N N 153 
CYS C   OXT  sing N N 154 
CYS CB  SG   sing N N 155 
CYS CB  HB2  sing N N 156 
CYS CB  HB3  sing N N 157 
CYS SG  HG   sing N N 158 
CYS OXT HXT  sing N N 159 
GLN N   CA   sing N N 160 
GLN N   H    sing N N 161 
GLN N   H2   sing N N 162 
GLN CA  C    sing N N 163 
GLN CA  CB   sing N N 164 
GLN CA  HA   sing N N 165 
GLN C   O    doub N N 166 
GLN C   OXT  sing N N 167 
GLN CB  CG   sing N N 168 
GLN CB  HB2  sing N N 169 
GLN CB  HB3  sing N N 170 
GLN CG  CD   sing N N 171 
GLN CG  HG2  sing N N 172 
GLN CG  HG3  sing N N 173 
GLN CD  OE1  doub N N 174 
GLN CD  NE2  sing N N 175 
GLN NE2 HE21 sing N N 176 
GLN NE2 HE22 sing N N 177 
GLN OXT HXT  sing N N 178 
GLU N   CA   sing N N 179 
GLU N   H    sing N N 180 
GLU N   H2   sing N N 181 
GLU CA  C    sing N N 182 
GLU CA  CB   sing N N 183 
GLU CA  HA   sing N N 184 
GLU C   O    doub N N 185 
GLU C   OXT  sing N N 186 
GLU CB  CG   sing N N 187 
GLU CB  HB2  sing N N 188 
GLU CB  HB3  sing N N 189 
GLU CG  CD   sing N N 190 
GLU CG  HG2  sing N N 191 
GLU CG  HG3  sing N N 192 
GLU CD  OE1  doub N N 193 
GLU CD  OE2  sing N N 194 
GLU OE2 HE2  sing N N 195 
GLU OXT HXT  sing N N 196 
GLY N   CA   sing N N 197 
GLY N   H    sing N N 198 
GLY N   H2   sing N N 199 
GLY CA  C    sing N N 200 
GLY CA  HA2  sing N N 201 
GLY CA  HA3  sing N N 202 
GLY C   O    doub N N 203 
GLY C   OXT  sing N N 204 
GLY OXT HXT  sing N N 205 
HIS N   CA   sing N N 206 
HIS N   H    sing N N 207 
HIS N   H2   sing N N 208 
HIS CA  C    sing N N 209 
HIS CA  CB   sing N N 210 
HIS CA  HA   sing N N 211 
HIS C   O    doub N N 212 
HIS C   OXT  sing N N 213 
HIS CB  CG   sing N N 214 
HIS CB  HB2  sing N N 215 
HIS CB  HB3  sing N N 216 
HIS CG  ND1  sing Y N 217 
HIS CG  CD2  doub Y N 218 
HIS ND1 CE1  doub Y N 219 
HIS ND1 HD1  sing N N 220 
HIS CD2 NE2  sing Y N 221 
HIS CD2 HD2  sing N N 222 
HIS CE1 NE2  sing Y N 223 
HIS CE1 HE1  sing N N 224 
HIS NE2 HE2  sing N N 225 
HIS OXT HXT  sing N N 226 
HOH O   H1   sing N N 227 
HOH O   H2   sing N N 228 
ILE N   CA   sing N N 229 
ILE N   H    sing N N 230 
ILE N   H2   sing N N 231 
ILE CA  C    sing N N 232 
ILE CA  CB   sing N N 233 
ILE CA  HA   sing N N 234 
ILE C   O    doub N N 235 
ILE C   OXT  sing N N 236 
ILE CB  CG1  sing N N 237 
ILE CB  CG2  sing N N 238 
ILE CB  HB   sing N N 239 
ILE CG1 CD1  sing N N 240 
ILE CG1 HG12 sing N N 241 
ILE CG1 HG13 sing N N 242 
ILE CG2 HG21 sing N N 243 
ILE CG2 HG22 sing N N 244 
ILE CG2 HG23 sing N N 245 
ILE CD1 HD11 sing N N 246 
ILE CD1 HD12 sing N N 247 
ILE CD1 HD13 sing N N 248 
ILE OXT HXT  sing N N 249 
LEU N   CA   sing N N 250 
LEU N   H    sing N N 251 
LEU N   H2   sing N N 252 
LEU CA  C    sing N N 253 
LEU CA  CB   sing N N 254 
LEU CA  HA   sing N N 255 
LEU C   O    doub N N 256 
LEU C   OXT  sing N N 257 
LEU CB  CG   sing N N 258 
LEU CB  HB2  sing N N 259 
LEU CB  HB3  sing N N 260 
LEU CG  CD1  sing N N 261 
LEU CG  CD2  sing N N 262 
LEU CG  HG   sing N N 263 
LEU CD1 HD11 sing N N 264 
LEU CD1 HD12 sing N N 265 
LEU CD1 HD13 sing N N 266 
LEU CD2 HD21 sing N N 267 
LEU CD2 HD22 sing N N 268 
LEU CD2 HD23 sing N N 269 
LEU OXT HXT  sing N N 270 
LYS N   CA   sing N N 271 
LYS N   H    sing N N 272 
LYS N   H2   sing N N 273 
LYS CA  C    sing N N 274 
LYS CA  CB   sing N N 275 
LYS CA  HA   sing N N 276 
LYS C   O    doub N N 277 
LYS C   OXT  sing N N 278 
LYS CB  CG   sing N N 279 
LYS CB  HB2  sing N N 280 
LYS CB  HB3  sing N N 281 
LYS CG  CD   sing N N 282 
LYS CG  HG2  sing N N 283 
LYS CG  HG3  sing N N 284 
LYS CD  CE   sing N N 285 
LYS CD  HD2  sing N N 286 
LYS CD  HD3  sing N N 287 
LYS CE  NZ   sing N N 288 
LYS CE  HE2  sing N N 289 
LYS CE  HE3  sing N N 290 
LYS NZ  HZ1  sing N N 291 
LYS NZ  HZ2  sing N N 292 
LYS NZ  HZ3  sing N N 293 
LYS OXT HXT  sing N N 294 
MET N   CA   sing N N 295 
MET N   H    sing N N 296 
MET N   H2   sing N N 297 
MET CA  C    sing N N 298 
MET CA  CB   sing N N 299 
MET CA  HA   sing N N 300 
MET C   O    doub N N 301 
MET C   OXT  sing N N 302 
MET CB  CG   sing N N 303 
MET CB  HB2  sing N N 304 
MET CB  HB3  sing N N 305 
MET CG  SD   sing N N 306 
MET CG  HG2  sing N N 307 
MET CG  HG3  sing N N 308 
MET SD  CE   sing N N 309 
MET CE  HE1  sing N N 310 
MET CE  HE2  sing N N 311 
MET CE  HE3  sing N N 312 
MET OXT HXT  sing N N 313 
PHE N   CA   sing N N 314 
PHE N   H    sing N N 315 
PHE N   H2   sing N N 316 
PHE CA  C    sing N N 317 
PHE CA  CB   sing N N 318 
PHE CA  HA   sing N N 319 
PHE C   O    doub N N 320 
PHE C   OXT  sing N N 321 
PHE CB  CG   sing N N 322 
PHE CB  HB2  sing N N 323 
PHE CB  HB3  sing N N 324 
PHE CG  CD1  doub Y N 325 
PHE CG  CD2  sing Y N 326 
PHE CD1 CE1  sing Y N 327 
PHE CD1 HD1  sing N N 328 
PHE CD2 CE2  doub Y N 329 
PHE CD2 HD2  sing N N 330 
PHE CE1 CZ   doub Y N 331 
PHE CE1 HE1  sing N N 332 
PHE CE2 CZ   sing Y N 333 
PHE CE2 HE2  sing N N 334 
PHE CZ  HZ   sing N N 335 
PHE OXT HXT  sing N N 336 
PRO N   CA   sing N N 337 
PRO N   CD   sing N N 338 
PRO N   H    sing N N 339 
PRO CA  C    sing N N 340 
PRO CA  CB   sing N N 341 
PRO CA  HA   sing N N 342 
PRO C   O    doub N N 343 
PRO C   OXT  sing N N 344 
PRO CB  CG   sing N N 345 
PRO CB  HB2  sing N N 346 
PRO CB  HB3  sing N N 347 
PRO CG  CD   sing N N 348 
PRO CG  HG2  sing N N 349 
PRO CG  HG3  sing N N 350 
PRO CD  HD2  sing N N 351 
PRO CD  HD3  sing N N 352 
PRO OXT HXT  sing N N 353 
SAR N   CA   sing N N 354 
SAR N   CN   sing N N 355 
SAR N   H    sing N N 356 
SAR CA  C    sing N N 357 
SAR CA  HA2  sing N N 358 
SAR CA  HA3  sing N N 359 
SAR C   O    doub N N 360 
SAR C   OXT  sing N N 361 
SAR CN  HN1  sing N N 362 
SAR CN  HN2  sing N N 363 
SAR CN  HN3  sing N N 364 
SAR OXT HXT  sing N N 365 
SER N   CA   sing N N 366 
SER N   H    sing N N 367 
SER N   H2   sing N N 368 
SER CA  C    sing N N 369 
SER CA  CB   sing N N 370 
SER CA  HA   sing N N 371 
SER C   O    doub N N 372 
SER C   OXT  sing N N 373 
SER CB  OG   sing N N 374 
SER CB  HB2  sing N N 375 
SER CB  HB3  sing N N 376 
SER OG  HG   sing N N 377 
SER OXT HXT  sing N N 378 
THR N   CA   sing N N 379 
THR N   H    sing N N 380 
THR N   H2   sing N N 381 
THR CA  C    sing N N 382 
THR CA  CB   sing N N 383 
THR CA  HA   sing N N 384 
THR C   O    doub N N 385 
THR C   OXT  sing N N 386 
THR CB  OG1  sing N N 387 
THR CB  CG2  sing N N 388 
THR CB  HB   sing N N 389 
THR OG1 HG1  sing N N 390 
THR CG2 HG21 sing N N 391 
THR CG2 HG22 sing N N 392 
THR CG2 HG23 sing N N 393 
THR OXT HXT  sing N N 394 
TRP N   CA   sing N N 395 
TRP N   H    sing N N 396 
TRP N   H2   sing N N 397 
TRP CA  C    sing N N 398 
TRP CA  CB   sing N N 399 
TRP CA  HA   sing N N 400 
TRP C   O    doub N N 401 
TRP C   OXT  sing N N 402 
TRP CB  CG   sing N N 403 
TRP CB  HB2  sing N N 404 
TRP CB  HB3  sing N N 405 
TRP CG  CD1  doub Y N 406 
TRP CG  CD2  sing Y N 407 
TRP CD1 NE1  sing Y N 408 
TRP CD1 HD1  sing N N 409 
TRP CD2 CE2  doub Y N 410 
TRP CD2 CE3  sing Y N 411 
TRP NE1 CE2  sing Y N 412 
TRP NE1 HE1  sing N N 413 
TRP CE2 CZ2  sing Y N 414 
TRP CE3 CZ3  doub Y N 415 
TRP CE3 HE3  sing N N 416 
TRP CZ2 CH2  doub Y N 417 
TRP CZ2 HZ2  sing N N 418 
TRP CZ3 CH2  sing Y N 419 
TRP CZ3 HZ3  sing N N 420 
TRP CH2 HH2  sing N N 421 
TRP OXT HXT  sing N N 422 
TYR N   CA   sing N N 423 
TYR N   H    sing N N 424 
TYR N   H2   sing N N 425 
TYR CA  C    sing N N 426 
TYR CA  CB   sing N N 427 
TYR CA  HA   sing N N 428 
TYR C   O    doub N N 429 
TYR C   OXT  sing N N 430 
TYR CB  CG   sing N N 431 
TYR CB  HB2  sing N N 432 
TYR CB  HB3  sing N N 433 
TYR CG  CD1  doub Y N 434 
TYR CG  CD2  sing Y N 435 
TYR CD1 CE1  sing Y N 436 
TYR CD1 HD1  sing N N 437 
TYR CD2 CE2  doub Y N 438 
TYR CD2 HD2  sing N N 439 
TYR CE1 CZ   doub Y N 440 
TYR CE1 HE1  sing N N 441 
TYR CE2 CZ   sing Y N 442 
TYR CE2 HE2  sing N N 443 
TYR CZ  OH   sing N N 444 
TYR OH  HH   sing N N 445 
TYR OXT HXT  sing N N 446 
VAL N   CA   sing N N 447 
VAL N   H    sing N N 448 
VAL N   H2   sing N N 449 
VAL CA  C    sing N N 450 
VAL CA  CB   sing N N 451 
VAL CA  HA   sing N N 452 
VAL C   O    doub N N 453 
VAL C   OXT  sing N N 454 
VAL CB  CG1  sing N N 455 
VAL CB  CG2  sing N N 456 
VAL CB  HB   sing N N 457 
VAL CG1 HG11 sing N N 458 
VAL CG1 HG12 sing N N 459 
VAL CG1 HG13 sing N N 460 
VAL CG2 HG21 sing N N 461 
VAL CG2 HG22 sing N N 462 
VAL CG2 HG23 sing N N 463 
VAL OXT HXT  sing N N 464 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-08-21 
_em_admin.deposition_site    PDBJ 
_em_admin.entry_id           9J8C 
_em_admin.last_update        2025-03-26 
_em_admin.map_release_date   2025-03-05 
_em_admin.title              'Human Glycine Transporter 1 in the Sarcosine-Bound State with an Occluded Conformation' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING ONLY' 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          9606 
_em_entity_assembly_recombinant.organism             'Homo sapiens' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         60 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K2 SUMMIT (4k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'       ? 1  1 ? ? ? ? 
'IMAGE ACQUISITION'        ? 2  ? ? 1 ? ? 
MASKING                    ? 3  ? ? ? ? ? 
'CTF CORRECTION'           ? 4  1 ? ? ? ? 
'LAYERLINE INDEXING'       ? 5  ? ? ? ? ? 
'DIFFRACTION INDEXING'     ? 6  ? ? ? ? ? 
'MODEL FITTING'            ? 7  ? ? ? ? ? 
'MODEL REFINEMENT'         ? 8  ? ? ? ? ? 
OTHER                      ? 9  ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT' ? 10 1 ? ? ? ? 
'FINAL EULER ASSIGNMENT'   ? 11 1 ? ? ? ? 
CLASSIFICATION             ? 12 1 ? ? ? ? 
RECONSTRUCTION             ? 13 1 ? ? ? ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           92157102 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    9J8C 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
CL 
N  
NA 
O  
S  
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . ARG A 1 46  ? 136.139 110.016 102.926 1.00 79.99  ? 46  ARG A N   1 
ATOM   2    C  CA  . ARG A 1 46  ? 134.801 110.300 103.432 1.00 82.77  ? 46  ARG A CA  1 
ATOM   3    C  C   . ARG A 1 46  ? 134.834 110.627 104.922 1.00 84.01  ? 46  ARG A C   1 
ATOM   4    O  O   . ARG A 1 46  ? 134.248 111.614 105.364 1.00 81.38  ? 46  ARG A O   1 
ATOM   5    C  CB  . ARG A 1 46  ? 133.868 109.116 103.171 1.00 77.65  ? 46  ARG A CB  1 
ATOM   6    C  CG  . ARG A 1 46  ? 132.437 109.337 103.635 1.00 75.72  ? 46  ARG A CG  1 
ATOM   7    C  CD  . ARG A 1 46  ? 131.494 109.519 102.458 1.00 75.54  ? 46  ARG A CD  1 
ATOM   8    N  NE  . ARG A 1 46  ? 130.149 109.876 102.891 1.00 76.61  ? 46  ARG A NE  1 
ATOM   9    C  CZ  . ARG A 1 46  ? 129.259 110.502 102.133 1.00 82.23  ? 46  ARG A CZ  1 
ATOM   10   N  NH1 . ARG A 1 46  ? 129.537 110.853 100.889 1.00 79.88  ? 46  ARG A NH1 1 
ATOM   11   N  NH2 . ARG A 1 46  ? 128.061 110.783 102.637 1.00 81.72  ? 46  ARG A NH2 1 
ATOM   12   N  N   . GLY A 1 47  ? 135.530 109.793 105.690 1.00 87.30  ? 47  GLY A N   1 
ATOM   13   C  CA  . GLY A 1 47  ? 135.603 109.969 107.127 1.00 86.81  ? 47  GLY A CA  1 
ATOM   14   C  C   . GLY A 1 47  ? 134.887 108.868 107.880 1.00 87.03  ? 47  GLY A C   1 
ATOM   15   O  O   . GLY A 1 47  ? 133.657 108.869 107.973 1.00 84.87  ? 47  GLY A O   1 
ATOM   16   N  N   . ASN A 1 48  ? 135.649 107.923 108.427 1.00 88.57  ? 48  ASN A N   1 
ATOM   17   C  CA  . ASN A 1 48  ? 135.054 106.771 109.090 1.00 86.11  ? 48  ASN A CA  1 
ATOM   18   C  C   . ASN A 1 48  ? 134.378 107.183 110.391 1.00 88.33  ? 48  ASN A C   1 
ATOM   19   O  O   . ASN A 1 48  ? 134.676 108.236 110.960 1.00 91.72  ? 48  ASN A O   1 
ATOM   20   C  CB  . ASN A 1 48  ? 136.121 105.709 109.360 1.00 84.61  ? 48  ASN A CB  1 
ATOM   21   C  CG  . ASN A 1 48  ? 136.579 105.012 108.095 1.00 87.97  ? 48  ASN A CG  1 
ATOM   22   O  OD1 . ASN A 1 48  ? 135.779 104.729 107.205 1.00 90.25  ? 48  ASN A OD1 1 
ATOM   23   N  ND2 . ASN A 1 48  ? 137.874 104.735 108.009 1.00 86.56  ? 48  ASN A ND2 1 
ATOM   24   N  N   . TRP A 1 49  ? 133.452 106.340 110.856 1.00 84.89  ? 49  TRP A N   1 
ATOM   25   C  CA  . TRP A 1 49  ? 132.741 106.625 112.098 1.00 86.74  ? 49  TRP A CA  1 
ATOM   26   C  C   . TRP A 1 49  ? 133.691 106.649 113.288 1.00 90.74  ? 49  TRP A C   1 
ATOM   27   O  O   . TRP A 1 49  ? 133.471 107.387 114.255 1.00 92.57  ? 49  TRP A O   1 
ATOM   28   C  CB  . TRP A 1 49  ? 131.636 105.591 112.324 1.00 81.64  ? 49  TRP A CB  1 
ATOM   29   C  CG  . TRP A 1 49  ? 130.279 106.044 111.883 1.00 85.50  ? 49  TRP A CG  1 
ATOM   30   C  CD1 . TRP A 1 49  ? 129.576 105.596 110.803 1.00 84.65  ? 49  TRP A CD1 1 
ATOM   31   C  CD2 . TRP A 1 49  ? 129.459 107.037 112.510 1.00 90.86  ? 49  TRP A CD2 1 
ATOM   32   N  NE1 . TRP A 1 49  ? 128.370 106.247 110.719 1.00 81.00  ? 49  TRP A NE1 1 
ATOM   33   C  CE2 . TRP A 1 49  ? 128.274 107.138 111.755 1.00 87.61  ? 49  TRP A CE2 1 
ATOM   34   C  CE3 . TRP A 1 49  ? 129.612 107.851 113.636 1.00 89.35  ? 49  TRP A CE3 1 
ATOM   35   C  CZ2 . TRP A 1 49  ? 127.248 108.018 112.090 1.00 84.65  ? 49  TRP A CZ2 1 
ATOM   36   C  CZ3 . TRP A 1 49  ? 128.592 108.725 113.966 1.00 88.16  ? 49  TRP A CZ3 1 
ATOM   37   C  CH2 . TRP A 1 49  ? 127.425 108.801 113.196 1.00 84.96  ? 49  TRP A CH2 1 
ATOM   38   N  N   . GLY A 1 50  ? 134.754 105.852 113.233 1.00 96.29  ? 50  GLY A N   1 
ATOM   39   C  CA  . GLY A 1 50  ? 135.662 105.730 114.355 1.00 95.95  ? 50  GLY A CA  1 
ATOM   40   C  C   . GLY A 1 50  ? 135.417 104.460 115.141 1.00 100.21 ? 50  GLY A C   1 
ATOM   41   O  O   . GLY A 1 50  ? 135.832 103.373 114.725 1.00 102.01 ? 50  GLY A O   1 
ATOM   42   N  N   . ASN A 1 51  ? 134.746 104.583 116.281 1.00 104.90 ? 51  ASN A N   1 
ATOM   43   C  CA  . ASN A 1 51  ? 134.379 103.428 117.084 1.00 103.74 ? 51  ASN A CA  1 
ATOM   44   C  C   . ASN A 1 51  ? 133.029 102.878 116.632 1.00 103.55 ? 51  ASN A C   1 
ATOM   45   O  O   . ASN A 1 51  ? 132.145 103.615 116.189 1.00 104.24 ? 51  ASN A O   1 
ATOM   46   C  CB  . ASN A 1 51  ? 134.332 103.797 118.567 1.00 104.76 ? 51  ASN A CB  1 
ATOM   47   C  CG  . ASN A 1 51  ? 135.035 102.779 119.442 1.00 105.62 ? 51  ASN A CG  1 
ATOM   48   O  OD1 . ASN A 1 51  ? 135.030 101.583 119.150 1.00 104.58 ? 51  ASN A OD1 1 
ATOM   49   N  ND2 . ASN A 1 51  ? 135.644 103.249 120.524 1.00 105.13 ? 51  ASN A ND2 1 
ATOM   50   N  N   . GLN A 1 52  ? 132.882 101.558 116.746 1.00 100.76 ? 52  GLN A N   1 
ATOM   51   C  CA  . GLN A 1 52  ? 131.662 100.877 116.329 1.00 104.16 ? 52  GLN A CA  1 
ATOM   52   C  C   . GLN A 1 52  ? 130.510 101.118 117.301 1.00 104.49 ? 52  GLN A C   1 
ATOM   53   O  O   . GLN A 1 52  ? 129.365 101.318 116.877 1.00 102.11 ? 52  GLN A O   1 
ATOM   54   C  CB  . GLN A 1 52  ? 131.927 99.375  116.183 1.00 101.67 ? 52  GLN A CB  1 
ATOM   55   C  CG  . GLN A 1 52  ? 133.165 99.037  115.364 1.00 100.90 ? 52  GLN A CG  1 
ATOM   56   C  CD  . GLN A 1 52  ? 134.398 98.836  116.225 1.00 104.70 ? 52  GLN A CD  1 
ATOM   57   O  OE1 . GLN A 1 52  ? 134.524 99.429  117.296 1.00 104.45 ? 52  GLN A OE1 1 
ATOM   58   N  NE2 . GLN A 1 52  ? 135.317 97.998  115.758 1.00 104.53 ? 52  GLN A NE2 1 
ATOM   59   N  N   . ILE A 1 53  ? 130.801 101.106 118.602 1.00 100.87 ? 53  ILE A N   1 
ATOM   60   C  CA  . ILE A 1 53  ? 129.796 101.329 119.635 1.00 99.55  ? 53  ILE A CA  1 
ATOM   61   C  C   . ILE A 1 53  ? 129.206 102.718 119.445 1.00 98.78  ? 53  ILE A C   1 
ATOM   62   O  O   . ILE A 1 53  ? 128.023 102.947 119.721 1.00 94.43  ? 53  ILE A O   1 
ATOM   63   C  CB  . ILE A 1 53  ? 130.384 101.168 121.051 1.00 98.86  ? 53  ILE A CB  1 
ATOM   64   C  CG1 . ILE A 1 53  ? 131.210 99.882  121.162 1.00 100.32 ? 53  ILE A CG1 1 
ATOM   65   C  CG2 . ILE A 1 53  ? 129.276 101.175 122.093 1.00 94.90  ? 53  ILE A CG2 1 
ATOM   66   C  CD1 . ILE A 1 53  ? 132.697 100.070 120.917 1.00 98.50  ? 53  ILE A CD1 1 
ATOM   67   N  N   . GLU A 1 54  ? 130.028 103.654 118.967 1.00 96.36  ? 54  GLU A N   1 
ATOM   68   C  CA  . GLU A 1 54  ? 129.529 104.988 118.658 1.00 95.08  ? 54  GLU A CA  1 
ATOM   69   C  C   . GLU A 1 54  ? 128.450 104.928 117.584 1.00 97.83  ? 54  GLU A C   1 
ATOM   70   O  O   . GLU A 1 54  ? 127.403 105.574 117.704 1.00 97.42  ? 54  GLU A O   1 
ATOM   71   C  CB  . GLU A 1 54  ? 130.683 105.890 118.217 1.00 95.41  ? 54  GLU A CB  1 
ATOM   72   C  CG  . GLU A 1 54  ? 130.252 107.198 117.567 1.00 98.35  ? 54  GLU A CG  1 
ATOM   73   C  CD  . GLU A 1 54  ? 129.948 108.290 118.577 1.00 100.20 ? 54  GLU A CD  1 
ATOM   74   O  OE1 . GLU A 1 54  ? 129.331 107.992 119.621 1.00 99.46  ? 54  GLU A OE1 1 
ATOM   75   O  OE2 . GLU A 1 54  ? 130.330 109.452 118.325 1.00 101.87 ? 54  GLU A OE2 1 
ATOM   76   N  N   . PHE A 1 55  ? 128.683 104.142 116.529 1.00 87.36  ? 55  PHE A N   1 
ATOM   77   C  CA  . PHE A 1 55  ? 127.674 103.990 115.485 1.00 89.19  ? 55  PHE A CA  1 
ATOM   78   C  C   . PHE A 1 55  ? 126.416 103.320 116.020 1.00 88.63  ? 55  PHE A C   1 
ATOM   79   O  O   . PHE A 1 55  ? 125.298 103.741 115.700 1.00 84.10  ? 55  PHE A O   1 
ATOM   80   C  CB  . PHE A 1 55  ? 128.237 103.192 114.309 1.00 86.48  ? 55  PHE A CB  1 
ATOM   81   C  CG  . PHE A 1 55  ? 127.229 102.924 113.225 1.00 88.15  ? 55  PHE A CG  1 
ATOM   82   C  CD1 . PHE A 1 55  ? 126.784 103.946 112.404 1.00 86.82  ? 55  PHE A CD1 1 
ATOM   83   C  CD2 . PHE A 1 55  ? 126.719 101.652 113.035 1.00 86.24  ? 55  PHE A CD2 1 
ATOM   84   C  CE1 . PHE A 1 55  ? 125.854 103.702 111.408 1.00 81.44  ? 55  PHE A CE1 1 
ATOM   85   C  CE2 . PHE A 1 55  ? 125.789 101.402 112.042 1.00 85.39  ? 55  PHE A CE2 1 
ATOM   86   C  CZ  . PHE A 1 55  ? 125.357 102.430 111.228 1.00 82.74  ? 55  PHE A CZ  1 
ATOM   87   N  N   . VAL A 1 56  ? 126.575 102.273 116.834 1.00 84.25  ? 56  VAL A N   1 
ATOM   88   C  CA  . VAL A 1 56  ? 125.400 101.577 117.354 1.00 81.93  ? 56  VAL A CA  1 
ATOM   89   C  C   . VAL A 1 56  ? 124.572 102.493 118.246 1.00 81.56  ? 56  VAL A C   1 
ATOM   90   O  O   . VAL A 1 56  ? 123.337 102.484 118.174 1.00 79.21  ? 56  VAL A O   1 
ATOM   91   C  CB  . VAL A 1 56  ? 125.806 100.291 118.098 1.00 80.92  ? 56  VAL A CB  1 
ATOM   92   C  CG1 . VAL A 1 56  ? 124.585 99.423  118.345 1.00 78.13  ? 56  VAL A CG1 1 
ATOM   93   C  CG2 . VAL A 1 56  ? 126.832 99.519  117.293 1.00 80.37  ? 56  VAL A CG2 1 
ATOM   94   N  N   . LEU A 1 57  ? 125.219 103.301 119.086 1.00 84.18  ? 57  LEU A N   1 
ATOM   95   C  CA  . LEU A 1 57  ? 124.499 104.223 119.956 1.00 83.74  ? 57  LEU A CA  1 
ATOM   96   C  C   . LEU A 1 57  ? 123.883 105.386 119.188 1.00 81.48  ? 57  LEU A C   1 
ATOM   97   O  O   . LEU A 1 57  ? 122.783 105.834 119.527 1.00 82.16  ? 57  LEU A O   1 
ATOM   98   C  CB  . LEU A 1 57  ? 125.428 104.754 121.050 1.00 83.07  ? 57  LEU A CB  1 
ATOM   99   C  CG  . LEU A 1 57  ? 125.767 103.788 122.186 1.00 83.96  ? 57  LEU A CG  1 
ATOM   100  C  CD1 . LEU A 1 57  ? 126.404 104.530 123.348 1.00 84.17  ? 57  LEU A CD1 1 
ATOM   101  C  CD2 . LEU A 1 57  ? 124.528 103.036 122.645 1.00 79.97  ? 57  LEU A CD2 1 
ATOM   102  N  N   . THR A 1 58  ? 124.569 105.891 118.161 1.00 76.53  ? 58  THR A N   1 
ATOM   103  C  CA  . THR A 1 58  ? 124.011 106.962 117.348 1.00 75.51  ? 58  THR A CA  1 
ATOM   104  C  C   . THR A 1 58  ? 122.828 106.491 116.514 1.00 79.09  ? 58  THR A C   1 
ATOM   105  O  O   . THR A 1 58  ? 121.908 107.277 116.267 1.00 81.96  ? 58  THR A O   1 
ATOM   106  C  CB  . THR A 1 58  ? 125.093 107.546 116.439 1.00 77.95  ? 58  THR A CB  1 
ATOM   107  O  OG1 . THR A 1 58  ? 126.318 107.666 117.174 1.00 77.36  ? 58  THR A OG1 1 
ATOM   108  C  CG2 . THR A 1 58  ? 124.682 108.919 115.934 1.00 78.46  ? 58  THR A CG2 1 
ATOM   109  N  N   . SER A 1 59  ? 122.831 105.232 116.075 1.00 72.29  ? 59  SER A N   1 
ATOM   110  C  CA  . SER A 1 59  ? 121.706 104.713 115.306 1.00 69.58  ? 59  SER A CA  1 
ATOM   111  C  C   . SER A 1 59  ? 120.495 104.441 116.192 1.00 68.12  ? 59  SER A C   1 
ATOM   112  O  O   . SER A 1 59  ? 119.353 104.622 115.754 1.00 65.32  ? 59  SER A O   1 
ATOM   113  C  CB  . SER A 1 59  ? 122.124 103.446 114.562 1.00 70.92  ? 59  SER A CB  1 
ATOM   114  O  OG  . SER A 1 59  ? 122.797 103.762 113.356 1.00 72.96  ? 59  SER A OG  1 
ATOM   115  N  N   . VAL A 1 60  ? 120.719 104.005 117.434 1.00 63.83  ? 60  VAL A N   1 
ATOM   116  C  CA  . VAL A 1 60  ? 119.607 103.782 118.355 1.00 61.50  ? 60  VAL A CA  1 
ATOM   117  C  C   . VAL A 1 60  ? 118.958 105.104 118.745 1.00 59.49  ? 60  VAL A C   1 
ATOM   118  O  O   . VAL A 1 60  ? 117.729 105.204 118.837 1.00 66.20  ? 60  VAL A O   1 
ATOM   119  C  CB  . VAL A 1 60  ? 120.081 102.991 119.589 1.00 60.14  ? 60  VAL A CB  1 
ATOM   120  C  CG1 . VAL A 1 60  ? 118.989 102.934 120.635 1.00 57.59  ? 60  VAL A CG1 1 
ATOM   121  C  CG2 . VAL A 1 60  ? 120.470 101.581 119.189 1.00 62.87  ? 60  VAL A CG2 1 
ATOM   122  N  N   . GLY A 1 61  ? 119.765 106.140 118.973 1.00 48.92  ? 61  GLY A N   1 
ATOM   123  C  CA  . GLY A 1 61  ? 119.222 107.442 119.318 1.00 49.60  ? 61  GLY A CA  1 
ATOM   124  C  C   . GLY A 1 61  ? 118.449 108.115 118.205 1.00 50.60  ? 61  GLY A C   1 
ATOM   125  O  O   . GLY A 1 61  ? 117.603 108.969 118.492 1.00 60.16  ? 61  GLY A O   1 
ATOM   126  N  N   . TYR A 1 62  ? 118.718 107.756 116.953 1.00 52.24  ? 62  TYR A N   1 
ATOM   127  C  CA  . TYR A 1 62  ? 117.983 108.265 115.803 1.00 50.82  ? 62  TYR A CA  1 
ATOM   128  C  C   . TYR A 1 62  ? 116.736 107.449 115.494 1.00 55.65  ? 62  TYR A C   1 
ATOM   129  O  O   . TYR A 1 62  ? 115.723 108.012 115.068 1.00 54.59  ? 62  TYR A O   1 
ATOM   130  C  CB  . TYR A 1 62  ? 118.902 108.295 114.576 1.00 52.28  ? 62  TYR A CB  1 
ATOM   131  C  CG  . TYR A 1 62  ? 118.192 108.330 113.242 1.00 57.51  ? 62  TYR A CG  1 
ATOM   132  C  CD1 . TYR A 1 62  ? 117.517 109.467 112.821 1.00 52.77  ? 62  TYR A CD1 1 
ATOM   133  C  CD2 . TYR A 1 62  ? 118.214 107.231 112.395 1.00 60.43  ? 62  TYR A CD2 1 
ATOM   134  C  CE1 . TYR A 1 62  ? 116.876 109.504 111.599 1.00 54.43  ? 62  TYR A CE1 1 
ATOM   135  C  CE2 . TYR A 1 62  ? 117.575 107.259 111.173 1.00 57.94  ? 62  TYR A CE2 1 
ATOM   136  C  CZ  . TYR A 1 62  ? 116.908 108.398 110.780 1.00 59.16  ? 62  TYR A CZ  1 
ATOM   137  O  OH  . TYR A 1 62  ? 116.271 108.430 109.563 1.00 59.59  ? 62  TYR A OH  1 
ATOM   138  N  N   . ALA A 1 63  ? 116.784 106.132 115.712 1.00 52.58  ? 63  ALA A N   1 
ATOM   139  C  CA  . ALA A 1 63  ? 115.630 105.287 115.428 1.00 49.48  ? 63  ALA A CA  1 
ATOM   140  C  C   . ALA A 1 63  ? 114.538 105.458 116.476 1.00 43.70  ? 63  ALA A C   1 
ATOM   141  O  O   . ALA A 1 63  ? 113.347 105.449 116.145 1.00 43.69  ? 63  ALA A O   1 
ATOM   142  C  CB  . ALA A 1 63  ? 116.061 103.824 115.337 1.00 44.56  ? 63  ALA A CB  1 
ATOM   143  N  N   . VAL A 1 64  ? 114.916 105.609 117.741 1.00 39.76  ? 64  VAL A N   1 
ATOM   144  C  CA  . VAL A 1 64  ? 113.954 105.761 118.827 1.00 48.64  ? 64  VAL A CA  1 
ATOM   145  C  C   . VAL A 1 64  ? 113.649 107.243 119.000 1.00 46.20  ? 64  VAL A C   1 
ATOM   146  O  O   . VAL A 1 64  ? 114.554 108.050 119.232 1.00 45.13  ? 64  VAL A O   1 
ATOM   147  C  CB  . VAL A 1 64  ? 114.484 105.149 120.132 1.00 42.50  ? 64  VAL A CB  1 
ATOM   148  C  CG1 . VAL A 1 64  ? 113.509 105.401 121.269 1.00 40.32  ? 64  VAL A CG1 1 
ATOM   149  C  CG2 . VAL A 1 64  ? 114.727 103.659 119.957 1.00 34.67  ? 64  VAL A CG2 1 
ATOM   150  N  N   . GLY A 1 65  ? 112.373 107.601 118.889 1.00 41.23  ? 65  GLY A N   1 
ATOM   151  C  CA  . GLY A 1 65  ? 111.966 108.987 118.999 1.00 39.85  ? 65  GLY A CA  1 
ATOM   152  C  C   . GLY A 1 65  ? 110.499 109.155 119.333 1.00 42.44  ? 65  GLY A C   1 
ATOM   153  O  O   . GLY A 1 65  ? 109.947 108.393 120.130 1.00 47.08  ? 65  GLY A O   1 
ATOM   154  N  N   . LEU A 1 66  ? 109.856 110.154 118.726 1.00 41.49  ? 66  LEU A N   1 
ATOM   155  C  CA  . LEU A 1 66  ? 108.443 110.401 118.990 1.00 41.14  ? 66  LEU A CA  1 
ATOM   156  C  C   . LEU A 1 66  ? 107.537 109.378 118.323 1.00 37.59  ? 66  LEU A C   1 
ATOM   157  O  O   . LEU A 1 66  ? 106.372 109.256 118.713 1.00 47.65  ? 66  LEU A O   1 
ATOM   158  C  CB  . LEU A 1 66  ? 108.056 111.808 118.534 1.00 40.38  ? 66  LEU A CB  1 
ATOM   159  C  CG  . LEU A 1 66  ? 108.701 112.964 119.298 1.00 44.66  ? 66  LEU A CG  1 
ATOM   160  C  CD1 . LEU A 1 66  ? 108.275 114.292 118.705 1.00 44.44  ? 66  LEU A CD1 1 
ATOM   161  C  CD2 . LEU A 1 66  ? 108.343 112.893 120.771 1.00 40.62  ? 66  LEU A CD2 1 
ATOM   162  N  N   . GLY A 1 67  ? 108.036 108.641 117.333 1.00 43.74  ? 67  GLY A N   1 
ATOM   163  C  CA  . GLY A 1 67  ? 107.245 107.590 116.726 1.00 40.64  ? 67  GLY A CA  1 
ATOM   164  C  C   . GLY A 1 67  ? 107.071 106.356 117.579 1.00 40.41  ? 67  GLY A C   1 
ATOM   165  O  O   . GLY A 1 67  ? 106.255 105.494 117.244 1.00 41.74  ? 67  GLY A O   1 
ATOM   166  N  N   . ASN A 1 68  ? 107.820 106.254 118.675 1.00 47.64  ? 68  ASN A N   1 
ATOM   167  C  CA  . ASN A 1 68  ? 107.708 105.141 119.607 1.00 39.08  ? 68  ASN A CA  1 
ATOM   168  C  C   . ASN A 1 68  ? 106.785 105.434 120.778 1.00 38.32  ? 68  ASN A C   1 
ATOM   169  O  O   . ASN A 1 68  ? 106.142 104.514 121.290 1.00 46.28  ? 68  ASN A O   1 
ATOM   170  C  CB  . ASN A 1 68  ? 109.090 104.767 120.154 1.00 46.23  ? 68  ASN A CB  1 
ATOM   171  C  CG  . ASN A 1 68  ? 109.929 104.006 119.153 1.00 44.42  ? 68  ASN A CG  1 
ATOM   172  O  OD1 . ASN A 1 68  ? 110.073 104.422 118.006 1.00 41.30  ? 68  ASN A OD1 1 
ATOM   173  N  ND2 . ASN A 1 68  ? 110.493 102.887 119.584 1.00 41.44  ? 68  ASN A ND2 1 
ATOM   174  N  N   . VAL A 1 69  ? 106.704 106.690 121.212 1.00 36.16  ? 69  VAL A N   1 
ATOM   175  C  CA  . VAL A 1 69  ? 105.961 107.043 122.413 1.00 42.52  ? 69  VAL A CA  1 
ATOM   176  C  C   . VAL A 1 69  ? 104.729 107.892 122.127 1.00 42.26  ? 69  VAL A C   1 
ATOM   177  O  O   . VAL A 1 69  ? 103.855 107.993 123.001 1.00 51.40  ? 69  VAL A O   1 
ATOM   178  C  CB  . VAL A 1 69  ? 106.869 107.757 123.437 1.00 47.77  ? 69  VAL A CB  1 
ATOM   179  C  CG1 . VAL A 1 69  ? 107.769 106.755 124.139 1.00 38.05  ? 69  VAL A CG1 1 
ATOM   180  C  CG2 . VAL A 1 69  ? 107.696 108.830 122.756 1.00 49.24  ? 69  VAL A CG2 1 
ATOM   181  N  N   . TRP A 1 70  ? 104.624 108.500 120.948 1.00 41.76  ? 70  TRP A N   1 
ATOM   182  C  CA  . TRP A 1 70  ? 103.483 109.339 120.597 1.00 36.80  ? 70  TRP A CA  1 
ATOM   183  C  C   . TRP A 1 70  ? 102.642 108.775 119.464 1.00 34.89  ? 70  TRP A C   1 
ATOM   184  O  O   . TRP A 1 70  ? 101.414 108.805 119.544 1.00 45.42  ? 70  TRP A O   1 
ATOM   185  C  CB  . TRP A 1 70  ? 103.960 110.748 120.221 1.00 37.53  ? 70  TRP A CB  1 
ATOM   186  C  CG  . TRP A 1 70  ? 102.964 111.539 119.422 1.00 39.62  ? 70  TRP A CG  1 
ATOM   187  C  CD1 . TRP A 1 70  ? 101.849 112.168 119.894 1.00 44.05  ? 70  TRP A CD1 1 
ATOM   188  C  CD2 . TRP A 1 70  ? 102.996 111.786 118.011 1.00 42.98  ? 70  TRP A CD2 1 
ATOM   189  N  NE1 . TRP A 1 70  ? 101.184 112.787 118.866 1.00 42.36  ? 70  TRP A NE1 1 
ATOM   190  C  CE2 . TRP A 1 70  ? 101.867 112.568 117.699 1.00 48.87  ? 70  TRP A CE2 1 
ATOM   191  C  CE3 . TRP A 1 70  ? 103.868 111.420 116.982 1.00 38.80  ? 70  TRP A CE3 1 
ATOM   192  C  CZ2 . TRP A 1 70  ? 101.589 112.991 116.403 1.00 45.61  ? 70  TRP A CZ2 1 
ATOM   193  C  CZ3 . TRP A 1 70  ? 103.590 111.842 115.696 1.00 38.70  ? 70  TRP A CZ3 1 
ATOM   194  C  CH2 . TRP A 1 70  ? 102.460 112.618 115.418 1.00 44.26  ? 70  TRP A CH2 1 
ATOM   195  N  N   . ARG A 1 71  ? 103.270 108.250 118.412 1.00 39.29  ? 71  ARG A N   1 
ATOM   196  C  CA  . ARG A 1 71  ? 102.548 107.791 117.232 1.00 42.30  ? 71  ARG A CA  1 
ATOM   197  C  C   . ARG A 1 71  ? 102.018 106.370 117.376 1.00 46.33  ? 71  ARG A C   1 
ATOM   198  O  O   . ARG A 1 71  ? 100.893 106.086 116.952 1.00 47.95  ? 71  ARG A O   1 
ATOM   199  C  CB  . ARG A 1 71  ? 103.453 107.883 116.001 1.00 39.19  ? 71  ARG A CB  1 
ATOM   200  C  CG  . ARG A 1 71  ? 102.710 108.050 114.691 1.00 36.89  ? 71  ARG A CG  1 
ATOM   201  C  CD  . ARG A 1 71  ? 103.656 107.945 113.512 1.00 41.11  ? 71  ARG A CD  1 
ATOM   202  N  NE  . ARG A 1 71  ? 102.976 108.159 112.240 1.00 50.30  ? 71  ARG A NE  1 
ATOM   203  C  CZ  . ARG A 1 71  ? 102.849 107.240 111.294 1.00 47.97  ? 71  ARG A CZ  1 
ATOM   204  N  NH1 . ARG A 1 71  ? 103.332 106.019 111.447 1.00 40.94  ? 71  ARG A NH1 1 
ATOM   205  N  NH2 . ARG A 1 71  ? 102.222 107.553 110.165 1.00 42.77  ? 71  ARG A NH2 1 
ATOM   206  N  N   . PHE A 1 72  ? 102.808 105.468 117.957 1.00 36.36  ? 72  PHE A N   1 
ATOM   207  C  CA  . PHE A 1 72  ? 102.380 104.076 118.092 1.00 40.15  ? 72  PHE A CA  1 
ATOM   208  C  C   . PHE A 1 72  ? 101.124 103.910 118.943 1.00 46.78  ? 72  PHE A C   1 
ATOM   209  O  O   . PHE A 1 72  ? 100.201 103.200 118.502 1.00 48.61  ? 72  PHE A O   1 
ATOM   210  C  CB  . PHE A 1 72  ? 103.546 103.241 118.635 1.00 41.04  ? 72  PHE A CB  1 
ATOM   211  C  CG  . PHE A 1 72  ? 103.186 101.816 118.954 1.00 40.45  ? 72  PHE A CG  1 
ATOM   212  C  CD1 . PHE A 1 72  ? 103.202 100.847 117.967 1.00 38.93  ? 72  PHE A CD1 1 
ATOM   213  C  CD2 . PHE A 1 72  ? 102.850 101.443 120.244 1.00 44.54  ? 72  PHE A CD2 1 
ATOM   214  C  CE1 . PHE A 1 72  ? 102.877 99.538  118.257 1.00 38.54  ? 72  PHE A CE1 1 
ATOM   215  C  CE2 . PHE A 1 72  ? 102.523 100.134 120.539 1.00 44.57  ? 72  PHE A CE2 1 
ATOM   216  C  CZ  . PHE A 1 72  ? 102.539 99.181  119.544 1.00 37.16  ? 72  PHE A CZ  1 
ATOM   217  N  N   . PRO A 1 73  ? 101.017 104.493 120.147 1.00 46.51  ? 73  PRO A N   1 
ATOM   218  C  CA  . PRO A 1 73  ? 99.823  104.222 120.968 1.00 48.99  ? 73  PRO A CA  1 
ATOM   219  C  C   . PRO A 1 73  ? 98.512  104.649 120.332 1.00 49.43  ? 73  PRO A C   1 
ATOM   220  O  O   . PRO A 1 73  ? 97.521  103.920 120.447 1.00 52.51  ? 73  PRO A O   1 
ATOM   221  C  CB  . PRO A 1 73  ? 100.106 104.999 122.263 1.00 49.83  ? 73  PRO A CB  1 
ATOM   222  C  CG  . PRO A 1 73  ? 101.128 106.004 121.895 1.00 52.32  ? 73  PRO A CG  1 
ATOM   223  C  CD  . PRO A 1 73  ? 101.981 105.334 120.878 1.00 43.62  ? 73  PRO A CD  1 
ATOM   224  N  N   . TYR A 1 74  ? 98.467  105.794 119.647 1.00 38.98  ? 74  TYR A N   1 
ATOM   225  C  CA  . TYR A 1 74  ? 97.185  106.247 119.117 1.00 48.62  ? 74  TYR A CA  1 
ATOM   226  C  C   . TYR A 1 74  ? 96.787  105.481 117.858 1.00 48.08  ? 74  TYR A C   1 
ATOM   227  O  O   . TYR A 1 74  ? 95.597  105.214 117.657 1.00 47.71  ? 74  TYR A O   1 
ATOM   228  C  CB  . TYR A 1 74  ? 97.212  107.769 118.903 1.00 51.68  ? 74  TYR A CB  1 
ATOM   229  C  CG  . TYR A 1 74  ? 97.531  108.300 117.518 1.00 51.56  ? 74  TYR A CG  1 
ATOM   230  C  CD1 . TYR A 1 74  ? 96.566  108.330 116.518 1.00 45.32  ? 74  TYR A CD1 1 
ATOM   231  C  CD2 . TYR A 1 74  ? 98.784  108.822 117.228 1.00 51.60  ? 74  TYR A CD2 1 
ATOM   232  C  CE1 . TYR A 1 74  ? 96.850  108.832 115.265 1.00 42.02  ? 74  TYR A CE1 1 
ATOM   233  C  CE2 . TYR A 1 74  ? 99.077  109.327 115.977 1.00 43.89  ? 74  TYR A CE2 1 
ATOM   234  C  CZ  . TYR A 1 74  ? 98.106  109.329 115.000 1.00 46.73  ? 74  TYR A CZ  1 
ATOM   235  O  OH  . TYR A 1 74  ? 98.394  109.831 113.752 1.00 44.99  ? 74  TYR A OH  1 
ATOM   236  N  N   . LEU A 1 75  ? 97.756  105.090 117.025 1.00 48.34  ? 75  LEU A N   1 
ATOM   237  C  CA  . LEU A 1 75  ? 97.453  104.184 115.920 1.00 48.91  ? 75  LEU A CA  1 
ATOM   238  C  C   . LEU A 1 75  ? 96.944  102.843 116.433 1.00 47.15  ? 75  LEU A C   1 
ATOM   239  O  O   . LEU A 1 75  ? 95.959  102.299 115.914 1.00 51.37  ? 75  LEU A O   1 
ATOM   240  C  CB  . LEU A 1 75  ? 98.692  103.981 115.047 1.00 48.01  ? 75  LEU A CB  1 
ATOM   241  C  CG  . LEU A 1 75  ? 99.135  105.110 114.116 1.00 50.61  ? 75  LEU A CG  1 
ATOM   242  C  CD1 . LEU A 1 75  ? 99.943  104.548 112.963 1.00 45.02  ? 75  LEU A CD1 1 
ATOM   243  C  CD2 . LEU A 1 75  ? 97.942  105.883 113.594 1.00 53.06  ? 75  LEU A CD2 1 
ATOM   244  N  N   . CYS A 1 76  ? 97.598  102.298 117.463 1.00 40.55  ? 76  CYS A N   1 
ATOM   245  C  CA  . CYS A 1 76  ? 97.152  101.032 118.033 1.00 36.31  ? 76  CYS A CA  1 
ATOM   246  C  C   . CYS A 1 76  ? 95.751  101.154 118.621 1.00 48.43  ? 76  CYS A C   1 
ATOM   247  O  O   . CYS A 1 76  ? 94.933  100.238 118.487 1.00 50.52  ? 76  CYS A O   1 
ATOM   248  C  CB  . CYS A 1 76  ? 98.145  100.559 119.095 1.00 38.91  ? 76  CYS A CB  1 
ATOM   249  S  SG  . CYS A 1 76  ? 97.750  98.965  119.846 1.00 64.59  ? 76  CYS A SG  1 
ATOM   250  N  N   . TYR A 1 77  ? 95.457  102.280 119.277 1.00 48.96  ? 77  TYR A N   1 
ATOM   251  C  CA  . TYR A 1 77  ? 94.139  102.465 119.876 1.00 43.92  ? 77  TYR A CA  1 
ATOM   252  C  C   . TYR A 1 77  ? 93.056  102.612 118.815 1.00 49.79  ? 77  TYR A C   1 
ATOM   253  O  O   . TYR A 1 77  ? 91.970  102.037 118.950 1.00 54.47  ? 77  TYR A O   1 
ATOM   254  C  CB  . TYR A 1 77  ? 94.145  103.679 120.803 1.00 43.79  ? 77  TYR A CB  1 
ATOM   255  C  CG  . TYR A 1 77  ? 92.873  103.825 121.605 1.00 50.58  ? 77  TYR A CG  1 
ATOM   256  C  CD1 . TYR A 1 77  ? 92.519  102.880 122.557 1.00 52.79  ? 77  TYR A CD1 1 
ATOM   257  C  CD2 . TYR A 1 77  ? 92.021  104.903 121.407 1.00 47.88  ? 77  TYR A CD2 1 
ATOM   258  C  CE1 . TYR A 1 77  ? 91.359  103.005 123.289 1.00 50.40  ? 77  TYR A CE1 1 
ATOM   259  C  CE2 . TYR A 1 77  ? 90.858  105.035 122.135 1.00 47.37  ? 77  TYR A CE2 1 
ATOM   260  C  CZ  . TYR A 1 77  ? 90.532  104.083 123.075 1.00 49.68  ? 77  TYR A CZ  1 
ATOM   261  O  OH  . TYR A 1 77  ? 89.375  104.209 123.805 1.00 53.38  ? 77  TYR A OH  1 
ATOM   262  N  N   . ARG A 1 78  ? 93.322  103.381 117.754 1.00 51.90  ? 78  ARG A N   1 
ATOM   263  C  CA  . ARG A 1 78  ? 92.304  103.559 116.725 1.00 46.58  ? 78  ARG A CA  1 
ATOM   264  C  C   . ARG A 1 78  ? 92.112  102.297 115.895 1.00 51.21  ? 78  ARG A C   1 
ATOM   265  O  O   . ARG A 1 78  ? 91.039  102.099 115.316 1.00 59.73  ? 78  ARG A O   1 
ATOM   266  C  CB  . ARG A 1 78  ? 92.649  104.743 115.821 1.00 46.82  ? 78  ARG A CB  1 
ATOM   267  C  CG  . ARG A 1 78  ? 93.875  104.550 114.960 1.00 48.53  ? 78  ARG A CG  1 
ATOM   268  C  CD  . ARG A 1 78  ? 94.172  105.800 114.156 1.00 57.59  ? 78  ARG A CD  1 
ATOM   269  N  NE  . ARG A 1 78  ? 94.008  105.584 112.724 1.00 59.64  ? 78  ARG A NE  1 
ATOM   270  C  CZ  . ARG A 1 78  ? 94.586  106.323 111.787 1.00 60.53  ? 78  ARG A CZ  1 
ATOM   271  N  NH1 . ARG A 1 78  ? 95.356  107.352 112.096 1.00 55.16  ? 78  ARG A NH1 1 
ATOM   272  N  NH2 . ARG A 1 78  ? 94.387  106.021 110.508 1.00 61.36  ? 78  ARG A NH2 1 
ATOM   273  N  N   . ASN A 1 79  ? 93.125  101.431 115.825 1.00 55.90  ? 79  ASN A N   1 
ATOM   274  C  CA  . ASN A 1 79  ? 92.993  100.161 115.125 1.00 44.76  ? 79  ASN A CA  1 
ATOM   275  C  C   . ASN A 1 79  ? 92.551  99.024  116.043 1.00 48.96  ? 79  ASN A C   1 
ATOM   276  O  O   . ASN A 1 79  ? 92.876  97.862  115.774 1.00 53.87  ? 79  ASN A O   1 
ATOM   277  C  CB  . ASN A 1 79  ? 94.303  99.806  114.423 1.00 43.41  ? 79  ASN A CB  1 
ATOM   278  C  CG  . ASN A 1 79  ? 94.525  100.622 113.168 1.00 50.11  ? 79  ASN A CG  1 
ATOM   279  O  OD1 . ASN A 1 79  ? 93.783  100.496 112.196 1.00 50.77  ? 79  ASN A OD1 1 
ATOM   280  N  ND2 . ASN A 1 79  ? 95.543  101.471 113.185 1.00 52.96  ? 79  ASN A ND2 1 
ATOM   281  N  N   . GLY A 1 80  ? 91.836  99.343  117.125 1.00 58.16  ? 80  GLY A N   1 
ATOM   282  C  CA  . GLY A 1 80  ? 91.169  98.363  117.989 1.00 56.43  ? 80  GLY A CA  1 
ATOM   283  C  C   . GLY A 1 80  ? 92.159  97.509  118.782 1.00 54.27  ? 80  GLY A C   1 
ATOM   284  O  O   . GLY A 1 80  ? 91.939  96.315  118.984 1.00 59.15  ? 80  GLY A O   1 
ATOM   285  N  N   . GLY A 1 81  ? 93.244  98.124  119.246 1.00 46.28  ? 81  GLY A N   1 
ATOM   286  C  CA  . GLY A 1 81  ? 94.141  97.478  120.188 1.00 42.79  ? 81  GLY A CA  1 
ATOM   287  C  C   . GLY A 1 81  ? 94.776  96.184  119.723 1.00 49.27  ? 81  GLY A C   1 
ATOM   288  O  O   . GLY A 1 81  ? 95.659  96.189  118.862 1.00 53.57  ? 81  GLY A O   1 
ATOM   289  N  N   . GLY A 1 82  ? 94.333  95.063  120.299 1.00 56.17  ? 82  GLY A N   1 
ATOM   290  C  CA  . GLY A 1 82  ? 94.946  93.773  120.027 1.00 53.57  ? 82  GLY A CA  1 
ATOM   291  C  C   . GLY A 1 82  ? 94.788  93.289  118.601 1.00 58.00  ? 82  GLY A C   1 
ATOM   292  O  O   . GLY A 1 82  ? 95.541  92.410  118.169 1.00 57.40  ? 82  GLY A O   1 
ATOM   293  N  N   . ALA A 1 83  ? 93.821  93.832  117.859 1.00 59.92  ? 83  ALA A N   1 
ATOM   294  C  CA  . ALA A 1 83  ? 93.689  93.506  116.444 1.00 53.05  ? 83  ALA A CA  1 
ATOM   295  C  C   . ALA A 1 83  ? 94.804  94.108  115.601 1.00 54.56  ? 83  ALA A C   1 
ATOM   296  O  O   . ALA A 1 83  ? 94.928  93.755  114.424 1.00 61.65  ? 83  ALA A O   1 
ATOM   297  C  CB  . ALA A 1 83  ? 92.334  93.980  115.919 1.00 49.70  ? 83  ALA A CB  1 
ATOM   298  N  N   . PHE A 1 84  ? 95.605  95.003  116.172 1.00 48.48  ? 84  PHE A N   1 
ATOM   299  C  CA  . PHE A 1 84  ? 96.702  95.662  115.480 1.00 44.55  ? 84  PHE A CA  1 
ATOM   300  C  C   . PHE A 1 84  ? 98.043  94.973  115.703 1.00 52.88  ? 84  PHE A C   1 
ATOM   301  O  O   . PHE A 1 84  ? 98.974  95.197  114.922 1.00 54.47  ? 84  PHE A O   1 
ATOM   302  C  CB  . PHE A 1 84  ? 96.772  97.126  115.940 1.00 40.79  ? 84  PHE A CB  1 
ATOM   303  C  CG  . PHE A 1 84  ? 97.856  97.935  115.287 1.00 46.45  ? 84  PHE A CG  1 
ATOM   304  C  CD1 . PHE A 1 84  ? 97.667  98.486  114.033 1.00 43.98  ? 84  PHE A CD1 1 
ATOM   305  C  CD2 . PHE A 1 84  ? 99.050  98.175  115.944 1.00 40.49  ? 84  PHE A CD2 1 
ATOM   306  C  CE1 . PHE A 1 84  ? 98.656  99.241  113.439 1.00 43.86  ? 84  PHE A CE1 1 
ATOM   307  C  CE2 . PHE A 1 84  ? 100.042 98.929  115.353 1.00 38.77  ? 84  PHE A CE2 1 
ATOM   308  C  CZ  . PHE A 1 84  ? 99.844  99.463  114.099 1.00 41.71  ? 84  PHE A CZ  1 
ATOM   309  N  N   . MET A 1 85  ? 98.157  94.130  116.731 1.00 48.40  ? 85  MET A N   1 
ATOM   310  C  CA  . MET A 1 85  ? 99.451  93.578  117.121 1.00 42.10  ? 85  MET A CA  1 
ATOM   311  C  C   . MET A 1 85  ? 99.933  92.495  116.161 1.00 47.07  ? 85  MET A C   1 
ATOM   312  O  O   . MET A 1 85  ? 101.113 92.465  115.796 1.00 60.75  ? 85  MET A O   1 
ATOM   313  C  CB  . MET A 1 85  ? 99.373  93.030  118.547 1.00 53.63  ? 85  MET A CB  1 
ATOM   314  C  CG  . MET A 1 85  ? 99.447  94.097  119.628 1.00 56.50  ? 85  MET A CG  1 
ATOM   315  S  SD  . MET A 1 85  ? 100.337 95.571  119.098 1.00 72.43  ? 85  MET A SD  1 
ATOM   316  C  CE  . MET A 1 85  ? 101.912 95.320  119.908 1.00 54.23  ? 85  MET A CE  1 
ATOM   317  N  N   . PHE A 1 86  ? 99.045  91.588  115.755 1.00 43.17  ? 86  PHE A N   1 
ATOM   318  C  CA  . PHE A 1 86  ? 99.461  90.485  114.889 1.00 40.98  ? 86  PHE A CA  1 
ATOM   319  C  C   . PHE A 1 86  ? 99.966  90.964  113.531 1.00 47.61  ? 86  PHE A C   1 
ATOM   320  O  O   . PHE A 1 86  ? 101.064 90.541  113.121 1.00 52.16  ? 86  PHE A O   1 
ATOM   321  C  CB  . PHE A 1 86  ? 98.309  89.479  114.762 1.00 45.18  ? 86  PHE A CB  1 
ATOM   322  C  CG  . PHE A 1 86  ? 98.618  88.299  113.884 1.00 50.90  ? 86  PHE A CG  1 
ATOM   323  C  CD1 . PHE A 1 86  ? 98.295  88.313  112.538 1.00 46.22  ? 86  PHE A CD1 1 
ATOM   324  C  CD2 . PHE A 1 86  ? 99.214  87.167  114.410 1.00 48.84  ? 86  PHE A CD2 1 
ATOM   325  C  CE1 . PHE A 1 86  ? 98.573  87.227  111.732 1.00 48.34  ? 86  PHE A CE1 1 
ATOM   326  C  CE2 . PHE A 1 86  ? 99.493  86.077  113.609 1.00 49.73  ? 86  PHE A CE2 1 
ATOM   327  C  CZ  . PHE A 1 86  ? 99.172  86.108  112.269 1.00 55.26  ? 86  PHE A CZ  1 
ATOM   328  N  N   . PRO A 1 87  ? 99.252  91.825  112.789 1.00 47.97  ? 87  PRO A N   1 
ATOM   329  C  CA  . PRO A 1 87  ? 99.850  92.372  111.561 1.00 36.65  ? 87  PRO A CA  1 
ATOM   330  C  C   . PRO A 1 87  ? 101.132 93.140  111.818 1.00 35.36  ? 87  PRO A C   1 
ATOM   331  O  O   . PRO A 1 87  ? 102.042 93.112  110.985 1.00 50.08  ? 87  PRO A O   1 
ATOM   332  C  CB  . PRO A 1 87  ? 98.744  93.283  111.010 1.00 41.60  ? 87  PRO A CB  1 
ATOM   333  C  CG  . PRO A 1 87  ? 97.495  92.739  111.574 1.00 37.99  ? 87  PRO A CG  1 
ATOM   334  C  CD  . PRO A 1 87  ? 97.857  92.277  112.947 1.00 48.82  ? 87  PRO A CD  1 
ATOM   335  N  N   . TYR A 1 88  ? 101.229 93.820  112.961 1.00 37.99  ? 88  TYR A N   1 
ATOM   336  C  CA  . TYR A 1 88  ? 102.432 94.580  113.286 1.00 44.10  ? 88  TYR A CA  1 
ATOM   337  C  C   . TYR A 1 88  ? 103.644 93.662  113.414 1.00 39.71  ? 88  TYR A C   1 
ATOM   338  O  O   . TYR A 1 88  ? 104.705 93.926  112.834 1.00 42.89  ? 88  TYR A O   1 
ATOM   339  C  CB  . TYR A 1 88  ? 102.186 95.373  114.572 1.00 38.31  ? 88  TYR A CB  1 
ATOM   340  C  CG  . TYR A 1 88  ? 103.390 96.057  115.177 1.00 43.05  ? 88  TYR A CG  1 
ATOM   341  C  CD1 . TYR A 1 88  ? 103.762 97.331  114.776 1.00 40.80  ? 88  TYR A CD1 1 
ATOM   342  C  CD2 . TYR A 1 88  ? 104.129 95.445  116.181 1.00 39.90  ? 88  TYR A CD2 1 
ATOM   343  C  CE1 . TYR A 1 88  ? 104.851 97.965  115.336 1.00 44.02  ? 88  TYR A CE1 1 
ATOM   344  C  CE2 . TYR A 1 88  ? 105.219 96.071  116.746 1.00 42.75  ? 88  TYR A CE2 1 
ATOM   345  C  CZ  . TYR A 1 88  ? 105.575 97.331  116.321 1.00 45.22  ? 88  TYR A CZ  1 
ATOM   346  O  OH  . TYR A 1 88  ? 106.661 97.959  116.883 1.00 48.13  ? 88  TYR A OH  1 
ATOM   347  N  N   . PHE A 1 89  ? 103.492 92.557  114.147 1.00 34.52  ? 89  PHE A N   1 
ATOM   348  C  CA  . PHE A 1 89  ? 104.600 91.621  114.311 1.00 43.54  ? 89  PHE A CA  1 
ATOM   349  C  C   . PHE A 1 89  ? 104.926 90.905  113.006 1.00 41.21  ? 89  PHE A C   1 
ATOM   350  O  O   . PHE A 1 89  ? 106.103 90.676  112.698 1.00 41.77  ? 89  PHE A O   1 
ATOM   351  C  CB  . PHE A 1 89  ? 104.277 90.614  115.414 1.00 37.76  ? 89  PHE A CB  1 
ATOM   352  C  CG  . PHE A 1 89  ? 104.505 91.145  116.800 1.00 47.81  ? 89  PHE A CG  1 
ATOM   353  C  CD1 . PHE A 1 89  ? 105.747 91.628  117.173 1.00 44.92  ? 89  PHE A CD1 1 
ATOM   354  C  CD2 . PHE A 1 89  ? 103.477 91.168  117.726 1.00 50.20  ? 89  PHE A CD2 1 
ATOM   355  C  CE1 . PHE A 1 89  ? 105.959 92.120  118.443 1.00 41.66  ? 89  PHE A CE1 1 
ATOM   356  C  CE2 . PHE A 1 89  ? 103.685 91.660  118.998 1.00 47.20  ? 89  PHE A CE2 1 
ATOM   357  C  CZ  . PHE A 1 89  ? 104.927 92.136  119.357 1.00 45.43  ? 89  PHE A CZ  1 
ATOM   358  N  N   . ILE A 1 90  ? 103.904 90.542  112.227 1.00 36.50  ? 90  ILE A N   1 
ATOM   359  C  CA  . ILE A 1 90  ? 104.155 89.898  110.938 1.00 39.07  ? 90  ILE A CA  1 
ATOM   360  C  C   . ILE A 1 90  ? 104.939 90.832  110.023 1.00 40.58  ? 90  ILE A C   1 
ATOM   361  O  O   . ILE A 1 90  ? 105.911 90.426  109.371 1.00 45.40  ? 90  ILE A O   1 
ATOM   362  C  CB  . ILE A 1 90  ? 102.831 89.449  110.294 1.00 37.91  ? 90  ILE A CB  1 
ATOM   363  C  CG1 . ILE A 1 90  ? 102.253 88.250  111.049 1.00 37.96  ? 90  ILE A CG1 1 
ATOM   364  C  CG2 . ILE A 1 90  ? 103.028 89.130  108.820 1.00 34.46  ? 90  ILE A CG2 1 
ATOM   365  C  CD1 . ILE A 1 90  ? 102.699 86.908  110.514 1.00 36.76  ? 90  ILE A CD1 1 
ATOM   366  N  N   . MET A 1 91  ? 104.531 92.103  109.970 1.00 40.02  ? 91  MET A N   1 
ATOM   367  C  CA  . MET A 1 91  ? 105.240 93.085  109.160 1.00 37.39  ? 91  MET A CA  1 
ATOM   368  C  C   . MET A 1 91  ? 106.677 93.247  109.630 1.00 39.46  ? 91  MET A C   1 
ATOM   369  O  O   . MET A 1 91  ? 107.603 93.254  108.814 1.00 45.11  ? 91  MET A O   1 
ATOM   370  C  CB  . MET A 1 91  ? 104.513 94.428  109.209 1.00 47.91  ? 91  MET A CB  1 
ATOM   371  C  CG  . MET A 1 91  ? 103.289 94.519  108.317 1.00 42.78  ? 91  MET A CG  1 
ATOM   372  S  SD  . MET A 1 91  ? 103.663 94.343  106.568 1.00 53.00  ? 91  MET A SD  1 
ATOM   373  C  CE  . MET A 1 91  ? 102.838 92.795  106.229 1.00 46.48  ? 91  MET A CE  1 
ATOM   374  N  N   . LEU A 1 92  ? 106.887 93.348  110.945 1.00 41.75  ? 92  LEU A N   1 
ATOM   375  C  CA  . LEU A 1 92  ? 108.244 93.502  111.459 1.00 36.31  ? 92  LEU A CA  1 
ATOM   376  C  C   . LEU A 1 92  ? 109.122 92.319  111.077 1.00 31.62  ? 92  LEU A C   1 
ATOM   377  O  O   . LEU A 1 92  ? 110.272 92.499  110.661 1.00 43.90  ? 92  LEU A O   1 
ATOM   378  C  CB  . LEU A 1 92  ? 108.222 93.670  112.976 1.00 40.97  ? 92  LEU A CB  1 
ATOM   379  C  CG  . LEU A 1 92  ? 109.587 93.535  113.648 1.00 39.64  ? 92  LEU A CG  1 
ATOM   380  C  CD1 . LEU A 1 92  ? 110.479 94.705  113.279 1.00 41.20  ? 92  LEU A CD1 1 
ATOM   381  C  CD2 . LEU A 1 92  ? 109.434 93.423  115.152 1.00 39.83  ? 92  LEU A CD2 1 
ATOM   382  N  N   . ILE A 1 93  ? 108.597 91.100  111.204 1.00 32.14  ? 93  ILE A N   1 
ATOM   383  C  CA  . ILE A 1 93  ? 109.419 89.925  110.938 1.00 36.61  ? 93  ILE A CA  1 
ATOM   384  C  C   . ILE A 1 93  ? 109.727 89.798  109.450 1.00 43.53  ? 93  ILE A C   1 
ATOM   385  O  O   . ILE A 1 93  ? 110.856 89.468  109.068 1.00 54.21  ? 93  ILE A O   1 
ATOM   386  C  CB  . ILE A 1 93  ? 108.739 88.659  111.490 1.00 40.10  ? 93  ILE A CB  1 
ATOM   387  C  CG1 . ILE A 1 93  ? 108.700 88.701  113.016 1.00 45.79  ? 93  ILE A CG1 1 
ATOM   388  C  CG2 . ILE A 1 93  ? 109.471 87.411  111.029 1.00 34.27  ? 93  ILE A CG2 1 
ATOM   389  C  CD1 . ILE A 1 93  ? 108.010 87.512  113.640 1.00 49.31  ? 93  ILE A CD1 1 
ATOM   390  N  N   . PHE A 1 94  ? 108.748 90.068  108.583 1.00 42.34  ? 94  PHE A N   1 
ATOM   391  C  CA  . PHE A 1 94  ? 108.896 89.684  107.184 1.00 43.14  ? 94  PHE A CA  1 
ATOM   392  C  C   . PHE A 1 94  ? 109.212 90.834  106.232 1.00 46.97  ? 94  PHE A C   1 
ATOM   393  O  O   . PHE A 1 94  ? 109.553 90.567  105.076 1.00 47.94  ? 94  PHE A O   1 
ATOM   394  C  CB  . PHE A 1 94  ? 107.632 88.961  106.704 1.00 48.17  ? 94  PHE A CB  1 
ATOM   395  C  CG  . PHE A 1 94  ? 107.545 87.535  107.166 1.00 45.36  ? 94  PHE A CG  1 
ATOM   396  C  CD1 . PHE A 1 94  ? 108.428 86.585  106.687 1.00 48.77  ? 94  PHE A CD1 1 
ATOM   397  C  CD2 . PHE A 1 94  ? 106.590 87.148  108.089 1.00 50.18  ? 94  PHE A CD2 1 
ATOM   398  C  CE1 . PHE A 1 94  ? 108.356 85.274  107.114 1.00 49.66  ? 94  PHE A CE1 1 
ATOM   399  C  CE2 . PHE A 1 94  ? 106.514 85.839  108.520 1.00 51.39  ? 94  PHE A CE2 1 
ATOM   400  C  CZ  . PHE A 1 94  ? 107.398 84.901  108.032 1.00 47.01  ? 94  PHE A CZ  1 
ATOM   401  N  N   . CYS A 1 95  ? 109.117 92.088  106.660 1.00 51.23  ? 95  CYS A N   1 
ATOM   402  C  CA  . CYS A 1 95  ? 109.407 93.177  105.733 1.00 41.77  ? 95  CYS A CA  1 
ATOM   403  C  C   . CYS A 1 95  ? 110.383 94.199  106.292 1.00 48.12  ? 95  CYS A C   1 
ATOM   404  O  O   . CYS A 1 95  ? 111.200 94.732  105.539 1.00 58.40  ? 95  CYS A O   1 
ATOM   405  C  CB  . CYS A 1 95  ? 108.099 93.879  105.331 1.00 52.87  ? 95  CYS A CB  1 
ATOM   406  S  SG  . CYS A 1 95  ? 107.234 93.121  103.940 1.00 70.15  ? 95  CYS A SG  1 
ATOM   407  N  N   . GLY A 1 96  ? 110.321 94.485  107.590 1.00 43.60  ? 96  GLY A N   1 
ATOM   408  C  CA  . GLY A 1 96  ? 111.118 95.545  108.175 1.00 42.74  ? 96  GLY A CA  1 
ATOM   409  C  C   . GLY A 1 96  ? 112.595 95.240  108.307 1.00 47.52  ? 96  GLY A C   1 
ATOM   410  O  O   . GLY A 1 96  ? 113.433 96.011  107.833 1.00 58.48  ? 96  GLY A O   1 
ATOM   411  N  N   . ILE A 1 97  ? 112.928 94.129  108.966 1.00 35.63  ? 97  ILE A N   1 
ATOM   412  C  CA  . ILE A 1 97  ? 114.336 93.776  109.165 1.00 42.63  ? 97  ILE A CA  1 
ATOM   413  C  C   . ILE A 1 97  ? 115.064 93.520  107.848 1.00 43.63  ? 97  ILE A C   1 
ATOM   414  O  O   . ILE A 1 97  ? 116.193 94.016  107.688 1.00 46.71  ? 97  ILE A O   1 
ATOM   415  C  CB  . ILE A 1 97  ? 114.451 92.600  110.151 1.00 42.28  ? 97  ILE A CB  1 
ATOM   416  C  CG1 . ILE A 1 97  ? 113.831 92.974  111.497 1.00 39.25  ? 97  ILE A CG1 1 
ATOM   417  C  CG2 . ILE A 1 97  ? 115.903 92.199  110.341 1.00 39.64  ? 97  ILE A CG2 1 
ATOM   418  C  CD1 . ILE A 1 97  ? 113.552 91.790  112.393 1.00 36.17  ? 97  ILE A CD1 1 
ATOM   419  N  N   . PRO A 1 98  ? 114.518 92.753  106.891 1.00 39.74  ? 98  PRO A N   1 
ATOM   420  C  CA  . PRO A 1 98  ? 115.247 92.570  105.622 1.00 41.28  ? 98  PRO A CA  1 
ATOM   421  C  C   . PRO A 1 98  ? 115.548 93.868  104.893 1.00 37.42  ? 98  PRO A C   1 
ATOM   422  O  O   . PRO A 1 98  ? 116.650 94.031  104.357 1.00 49.61  ? 98  PRO A O   1 
ATOM   423  C  CB  . PRO A 1 98  ? 114.306 91.668  104.813 1.00 41.86  ? 98  PRO A CB  1 
ATOM   424  C  CG  . PRO A 1 98  ? 113.565 90.909  105.837 1.00 43.85  ? 98  PRO A CG  1 
ATOM   425  C  CD  . PRO A 1 98  ? 113.329 91.882  106.949 1.00 35.19  ? 98  PRO A CD  1 
ATOM   426  N  N   . LEU A 1 99  ? 114.608 94.814  104.879 1.00 31.17  ? 99  LEU A N   1 
ATOM   427  C  CA  . LEU A 1 99  ? 114.853 96.083  104.205 1.00 43.16  ? 99  LEU A CA  1 
ATOM   428  C  C   . LEU A 1 99  ? 115.825 96.960  104.983 1.00 47.78  ? 99  LEU A C   1 
ATOM   429  O  O   . LEU A 1 99  ? 116.613 97.695  104.377 1.00 59.48  ? 99  LEU A O   1 
ATOM   430  C  CB  . LEU A 1 99  ? 113.530 96.812  103.971 1.00 43.29  ? 99  LEU A CB  1 
ATOM   431  C  CG  . LEU A 1 99  ? 112.615 96.156  102.932 1.00 47.52  ? 99  LEU A CG  1 
ATOM   432  C  CD1 . LEU A 1 99  ? 111.550 97.122  102.458 1.00 44.51  ? 99  LEU A CD1 1 
ATOM   433  C  CD2 . LEU A 1 99  ? 113.414 95.630  101.751 1.00 47.57  ? 99  LEU A CD2 1 
ATOM   434  N  N   . PHE A 1 100 ? 115.795 96.883  106.314 1.00 39.67  ? 100 PHE A N   1 
ATOM   435  C  CA  . PHE A 1 100 ? 116.794 97.557  107.137 1.00 36.17  ? 100 PHE A CA  1 
ATOM   436  C  C   . PHE A 1 100 ? 118.198 97.059  106.805 1.00 39.00  ? 100 PHE A C   1 
ATOM   437  O  O   . PHE A 1 100 ? 119.127 97.856  106.609 1.00 43.99  ? 100 PHE A O   1 
ATOM   438  C  CB  . PHE A 1 100 ? 116.460 97.324  108.613 1.00 34.04  ? 100 PHE A CB  1 
ATOM   439  C  CG  . PHE A 1 100 ? 117.078 98.317  109.555 1.00 36.34  ? 100 PHE A CG  1 
ATOM   440  C  CD1 . PHE A 1 100 ? 116.440 99.510  109.838 1.00 40.11  ? 100 PHE A CD1 1 
ATOM   441  C  CD2 . PHE A 1 100 ? 118.277 98.040  110.186 1.00 41.68  ? 100 PHE A CD2 1 
ATOM   442  C  CE1 . PHE A 1 100 ? 116.998 100.417 110.714 1.00 44.78  ? 100 PHE A CE1 1 
ATOM   443  C  CE2 . PHE A 1 100 ? 118.840 98.944  111.062 1.00 38.28  ? 100 PHE A CE2 1 
ATOM   444  C  CZ  . PHE A 1 100 ? 118.199 100.133 111.327 1.00 39.33  ? 100 PHE A CZ  1 
ATOM   445  N  N   . PHE A 1 101 ? 118.364 95.735  106.721 1.00 37.80  ? 101 PHE A N   1 
ATOM   446  C  CA  . PHE A 1 101 ? 119.661 95.164  106.368 1.00 49.49  ? 101 PHE A CA  1 
ATOM   447  C  C   . PHE A 1 101 ? 120.070 95.553  104.953 1.00 45.31  ? 101 PHE A C   1 
ATOM   448  O  O   . PHE A 1 101 ? 121.240 95.870  104.701 1.00 52.61  ? 101 PHE A O   1 
ATOM   449  C  CB  . PHE A 1 101 ? 119.616 93.643  106.517 1.00 45.67  ? 101 PHE A CB  1 
ATOM   450  C  CG  . PHE A 1 101 ? 120.919 92.960  106.205 1.00 43.00  ? 101 PHE A CG  1 
ATOM   451  C  CD1 . PHE A 1 101 ? 122.126 93.546  106.539 1.00 44.00  ? 101 PHE A CD1 1 
ATOM   452  C  CD2 . PHE A 1 101 ? 120.932 91.729  105.575 1.00 50.35  ? 101 PHE A CD2 1 
ATOM   453  C  CE1 . PHE A 1 101 ? 123.320 92.919  106.249 1.00 51.01  ? 101 PHE A CE1 1 
ATOM   454  C  CE2 . PHE A 1 101 ? 122.124 91.096  105.284 1.00 50.43  ? 101 PHE A CE2 1 
ATOM   455  C  CZ  . PHE A 1 101 ? 123.318 91.692  105.622 1.00 46.79  ? 101 PHE A CZ  1 
ATOM   456  N  N   . MET A 1 102 ? 119.121 95.526  104.015 1.00 34.52  ? 102 MET A N   1 
ATOM   457  C  CA  . MET A 1 102 ? 119.420 95.929  102.645 1.00 35.99  ? 102 MET A CA  1 
ATOM   458  C  C   . MET A 1 102 ? 119.923 97.362  102.590 1.00 45.64  ? 102 MET A C   1 
ATOM   459  O  O   . MET A 1 102 ? 120.918 97.654  101.918 1.00 50.35  ? 102 MET A O   1 
ATOM   460  C  CB  . MET A 1 102 ? 118.179 95.771  101.771 1.00 41.93  ? 102 MET A CB  1 
ATOM   461  C  CG  . MET A 1 102 ? 118.239 96.554  100.476 1.00 46.59  ? 102 MET A CG  1 
ATOM   462  S  SD  . MET A 1 102 ? 117.100 95.928  99.236  1.00 72.06  ? 102 MET A SD  1 
ATOM   463  C  CE  . MET A 1 102 ? 118.090 94.618  98.535  1.00 43.90  ? 102 MET A CE  1 
ATOM   464  N  N   . GLU A 1 103 ? 119.253 98.269  103.299 1.00 46.62  ? 103 GLU A N   1 
ATOM   465  C  CA  . GLU A 1 103 ? 119.666 99.666  103.303 1.00 40.77  ? 103 GLU A CA  1 
ATOM   466  C  C   . GLU A 1 103 ? 121.039 99.854  103.938 1.00 51.39  ? 103 GLU A C   1 
ATOM   467  O  O   . GLU A 1 103 ? 121.867 100.608 103.408 1.00 50.13  ? 103 GLU A O   1 
ATOM   468  C  CB  . GLU A 1 103 ? 118.621 100.503 104.030 1.00 34.94  ? 103 GLU A CB  1 
ATOM   469  C  CG  . GLU A 1 103 ? 118.677 101.965 103.699 1.00 52.03  ? 103 GLU A CG  1 
ATOM   470  C  CD  . GLU A 1 103 ? 117.314 102.605 103.715 1.00 64.13  ? 103 GLU A CD  1 
ATOM   471  O  OE1 . GLU A 1 103 ? 116.318 101.856 103.667 1.00 59.51  ? 103 GLU A OE1 1 
ATOM   472  O  OE2 . GLU A 1 103 ? 117.240 103.850 103.772 1.00 61.05  ? 103 GLU A OE2 1 
ATOM   473  N  N   . LEU A 1 104 ? 121.302 99.182  105.062 1.00 51.56  ? 104 LEU A N   1 
ATOM   474  C  CA  . LEU A 1 104 ? 122.607 99.315  105.704 1.00 37.90  ? 104 LEU A CA  1 
ATOM   475  C  C   . LEU A 1 104 ? 123.725 98.798  104.804 1.00 42.26  ? 104 LEU A C   1 
ATOM   476  O  O   . LEU A 1 104 ? 124.775 99.440  104.672 1.00 47.41  ? 104 LEU A O   1 
ATOM   477  C  CB  . LEU A 1 104 ? 122.610 98.586  107.047 1.00 42.53  ? 104 LEU A CB  1 
ATOM   478  C  CG  . LEU A 1 104 ? 122.462 99.462  108.293 1.00 47.42  ? 104 LEU A CG  1 
ATOM   479  C  CD1 . LEU A 1 104 ? 121.230 100.343 108.200 1.00 43.20  ? 104 LEU A CD1 1 
ATOM   480  C  CD2 . LEU A 1 104 ? 122.412 98.601  109.543 1.00 46.19  ? 104 LEU A CD2 1 
ATOM   481  N  N   . SER A 1 105 ? 123.516 97.643  104.165 1.00 44.25  ? 105 SER A N   1 
ATOM   482  C  CA  . SER A 1 105 ? 124.541 97.102  103.276 1.00 41.28  ? 105 SER A CA  1 
ATOM   483  C  C   . SER A 1 105 ? 124.738 97.989  102.052 1.00 41.20  ? 105 SER A C   1 
ATOM   484  O  O   . SER A 1 105 ? 125.872 98.185  101.597 1.00 37.27  ? 105 SER A O   1 
ATOM   485  C  CB  . SER A 1 105 ? 124.178 95.679  102.856 1.00 42.82  ? 105 SER A CB  1 
ATOM   486  O  OG  . SER A 1 105 ? 122.797 95.566  102.570 1.00 44.83  ? 105 SER A OG  1 
ATOM   487  N  N   . PHE A 1 106 ? 123.646 98.531  101.506 1.00 38.44  ? 106 PHE A N   1 
ATOM   488  C  CA  . PHE A 1 106 ? 123.744 99.436  100.366 1.00 39.71  ? 106 PHE A CA  1 
ATOM   489  C  C   . PHE A 1 106 ? 124.571 100.663 100.720 1.00 40.95  ? 106 PHE A C   1 
ATOM   490  O  O   . PHE A 1 106 ? 125.434 101.091 99.945  1.00 45.01  ? 106 PHE A O   1 
ATOM   491  C  CB  . PHE A 1 106 ? 122.342 99.843  99.911  1.00 38.81  ? 106 PHE A CB  1 
ATOM   492  C  CG  . PHE A 1 106 ? 122.269 100.300 98.485  1.00 44.81  ? 106 PHE A CG  1 
ATOM   493  C  CD1 . PHE A 1 106 ? 123.220 99.899  97.562  1.00 43.89  ? 106 PHE A CD1 1 
ATOM   494  C  CD2 . PHE A 1 106 ? 121.246 101.134 98.067  1.00 39.12  ? 106 PHE A CD2 1 
ATOM   495  C  CE1 . PHE A 1 106 ? 123.149 100.320 96.249  1.00 42.11  ? 106 PHE A CE1 1 
ATOM   496  C  CE2 . PHE A 1 106 ? 121.171 101.558 96.756  1.00 33.93  ? 106 PHE A CE2 1 
ATOM   497  C  CZ  . PHE A 1 106 ? 122.124 101.150 95.846  1.00 39.70  ? 106 PHE A CZ  1 
ATOM   498  N  N   . GLY A 1 107 ? 124.320 101.242 101.894 1.00 43.18  ? 107 GLY A N   1 
ATOM   499  C  CA  . GLY A 1 107 ? 125.105 102.389 102.318 1.00 35.12  ? 107 GLY A CA  1 
ATOM   500  C  C   . GLY A 1 107 ? 126.564 102.051 102.551 1.00 41.49  ? 107 GLY A C   1 
ATOM   501  O  O   . GLY A 1 107 ? 127.455 102.816 102.172 1.00 37.71  ? 107 GLY A O   1 
ATOM   502  N  N   . GLN A 1 108 ? 126.832 100.899 103.169 1.00 48.51  ? 108 GLN A N   1 
ATOM   503  C  CA  . GLN A 1 108 ? 128.201 100.571 103.555 1.00 33.10  ? 108 GLN A CA  1 
ATOM   504  C  C   . GLN A 1 108 ? 129.061 100.198 102.353 1.00 41.64  ? 108 GLN A C   1 
ATOM   505  O  O   . GLN A 1 108 ? 130.244 100.552 102.302 1.00 52.85  ? 108 GLN A O   1 
ATOM   506  C  CB  . GLN A 1 108 ? 128.197 99.440  104.580 1.00 40.79  ? 108 GLN A CB  1 
ATOM   507  C  CG  . GLN A 1 108 ? 129.564 99.109  105.146 1.00 35.93  ? 108 GLN A CG  1 
ATOM   508  C  CD  . GLN A 1 108 ? 129.490 98.157  106.317 1.00 37.34  ? 108 GLN A CD  1 
ATOM   509  O  OE1 . GLN A 1 108 ? 128.752 98.389  107.272 1.00 48.01  ? 108 GLN A OE1 1 
ATOM   510  N  NE2 . GLN A 1 108 ? 130.254 97.077  106.250 1.00 39.29  ? 108 GLN A NE2 1 
ATOM   511  N  N   . PHE A 1 109 ? 128.497 99.473  101.381 1.00 44.39  ? 109 PHE A N   1 
ATOM   512  C  CA  . PHE A 1 109 ? 129.318 98.956  100.287 1.00 35.01  ? 109 PHE A CA  1 
ATOM   513  C  C   . PHE A 1 109 ? 129.897 100.075 99.429  1.00 43.44  ? 109 PHE A C   1 
ATOM   514  O  O   . PHE A 1 109 ? 131.086 100.052 99.094  1.00 46.59  ? 109 PHE A O   1 
ATOM   515  C  CB  . PHE A 1 109 ? 128.504 97.992  99.423  1.00 37.65  ? 109 PHE A CB  1 
ATOM   516  C  CG  . PHE A 1 109 ? 129.309 97.323  98.344  1.00 38.02  ? 109 PHE A CG  1 
ATOM   517  C  CD1 . PHE A 1 109 ? 130.156 96.270  98.645  1.00 41.74  ? 109 PHE A CD1 1 
ATOM   518  C  CD2 . PHE A 1 109 ? 129.224 97.749  97.031  1.00 37.24  ? 109 PHE A CD2 1 
ATOM   519  C  CE1 . PHE A 1 109 ? 130.900 95.656  97.659  1.00 37.26  ? 109 PHE A CE1 1 
ATOM   520  C  CE2 . PHE A 1 109 ? 129.966 97.138  96.040  1.00 40.24  ? 109 PHE A CE2 1 
ATOM   521  C  CZ  . PHE A 1 109 ? 130.805 96.090  96.357  1.00 38.30  ? 109 PHE A CZ  1 
ATOM   522  N  N   . ALA A 1 110 ? 129.080 101.063 99.065  1.00 48.67  ? 110 ALA A N   1 
ATOM   523  C  CA  . ALA A 1 110 ? 129.514 102.103 98.141  1.00 44.56  ? 110 ALA A CA  1 
ATOM   524  C  C   . ALA A 1 110 ? 130.113 103.321 98.830  1.00 54.00  ? 110 ALA A C   1 
ATOM   525  O  O   . ALA A 1 110 ? 130.766 104.128 98.159  1.00 59.92  ? 110 ALA A O   1 
ATOM   526  C  CB  . ALA A 1 110 ? 128.343 102.553 97.264  1.00 42.01  ? 110 ALA A CB  1 
ATOM   527  N  N   . SER A 1 111 ? 129.916 103.467 100.142 1.00 51.25  ? 111 SER A N   1 
ATOM   528  C  CA  . SER A 1 111 ? 130.368 104.641 100.892 1.00 41.39  ? 111 SER A CA  1 
ATOM   529  C  C   . SER A 1 111 ? 129.798 105.932 100.304 1.00 53.57  ? 111 SER A C   1 
ATOM   530  O  O   . SER A 1 111 ? 130.519 106.909 100.101 1.00 53.84  ? 111 SER A O   1 
ATOM   531  C  CB  . SER A 1 111 ? 131.895 104.707 100.966 1.00 34.47  ? 111 SER A CB  1 
ATOM   532  O  OG  . SER A 1 111 ? 132.438 103.476 101.405 1.00 50.50  ? 111 SER A OG  1 
ATOM   533  N  N   . GLN A 1 112 ? 128.495 105.935 100.030 1.00 51.82  ? 112 GLN A N   1 
ATOM   534  C  CA  . GLN A 1 112 ? 127.806 107.090 99.478  1.00 40.95  ? 112 GLN A CA  1 
ATOM   535  C  C   . GLN A 1 112 ? 126.497 107.307 100.225 1.00 45.99  ? 112 GLN A C   1 
ATOM   536  O  O   . GLN A 1 112 ? 125.977 106.406 100.886 1.00 52.81  ? 112 GLN A O   1 
ATOM   537  C  CB  . GLN A 1 112 ? 127.527 106.921 97.978  1.00 40.85  ? 112 GLN A CB  1 
ATOM   538  C  CG  . GLN A 1 112 ? 128.770 106.777 97.117  1.00 42.89  ? 112 GLN A CG  1 
ATOM   539  C  CD  . GLN A 1 112 ? 129.457 108.100 96.853  1.00 52.26  ? 112 GLN A CD  1 
ATOM   540  O  OE1 . GLN A 1 112 ? 128.818 109.151 96.833  1.00 56.03  ? 112 GLN A OE1 1 
ATOM   541  N  NE2 . GLN A 1 112 ? 130.766 108.055 96.646  1.00 53.48  ? 112 GLN A NE2 1 
ATOM   542  N  N   . GLY A 1 113 ? 125.966 108.522 100.107 1.00 49.06  ? 113 GLY A N   1 
ATOM   543  C  CA  . GLY A 1 113 ? 124.724 108.890 100.752 1.00 44.97  ? 113 GLY A CA  1 
ATOM   544  C  C   . GLY A 1 113 ? 123.511 108.367 100.008 1.00 42.14  ? 113 GLY A C   1 
ATOM   545  O  O   . GLY A 1 113 ? 123.598 107.494 99.144  1.00 45.97  ? 113 GLY A O   1 
ATOM   546  N  N   . CYS A 1 114 ? 122.351 108.927 100.358 1.00 47.12  ? 114 CYS A N   1 
ATOM   547  C  CA  . CYS A 1 114 ? 121.091 108.456 99.794  1.00 49.24  ? 114 CYS A CA  1 
ATOM   548  C  C   . CYS A 1 114 ? 120.950 108.777 98.311  1.00 49.32  ? 114 CYS A C   1 
ATOM   549  O  O   . CYS A 1 114 ? 120.125 108.155 97.634  1.00 58.95  ? 114 CYS A O   1 
ATOM   550  C  CB  . CYS A 1 114 ? 119.912 109.051 100.566 1.00 50.13  ? 114 CYS A CB  1 
ATOM   551  S  SG  . CYS A 1 114 ? 119.652 110.818 100.307 1.00 70.73  ? 114 CYS A SG  1 
ATOM   552  N  N   . LEU A 1 115 ? 121.725 109.727 97.790  1.00 42.63  ? 115 LEU A N   1 
ATOM   553  C  CA  . LEU A 1 115 ? 121.661 110.072 96.376  1.00 42.58  ? 115 LEU A CA  1 
ATOM   554  C  C   . LEU A 1 115 ? 122.842 109.549 95.572  1.00 48.85  ? 115 LEU A C   1 
ATOM   555  O  O   . LEU A 1 115 ? 122.710 109.372 94.357  1.00 51.83  ? 115 LEU A O   1 
ATOM   556  C  CB  . LEU A 1 115 ? 121.576 111.593 96.202  1.00 45.62  ? 115 LEU A CB  1 
ATOM   557  C  CG  . LEU A 1 115 ? 120.180 112.207 96.303  1.00 48.37  ? 115 LEU A CG  1 
ATOM   558  C  CD1 . LEU A 1 115 ? 120.272 113.714 96.393  1.00 45.61  ? 115 LEU A CD1 1 
ATOM   559  C  CD2 . LEU A 1 115 ? 119.329 111.793 95.119  1.00 52.78  ? 115 LEU A CD2 1 
ATOM   560  N  N   . GLY A 1 116 ? 123.982 109.298 96.211  1.00 44.19  ? 116 GLY A N   1 
ATOM   561  C  CA  . GLY A 1 116 ? 125.150 108.802 95.515  1.00 37.64  ? 116 GLY A CA  1 
ATOM   562  C  C   . GLY A 1 116 ? 125.221 107.306 95.335  1.00 39.99  ? 116 GLY A C   1 
ATOM   563  O  O   . GLY A 1 116 ? 126.051 106.826 94.559  1.00 39.12  ? 116 GLY A O   1 
ATOM   564  N  N   . VAL A 1 117 ? 124.371 106.547 96.031  1.00 45.55  ? 117 VAL A N   1 
ATOM   565  C  CA  . VAL A 1 117 ? 124.373 105.096 95.887  1.00 41.80  ? 117 VAL A CA  1 
ATOM   566  C  C   . VAL A 1 117 ? 123.793 104.639 94.562  1.00 41.17  ? 117 VAL A C   1 
ATOM   567  O  O   . VAL A 1 117 ? 123.954 103.470 94.197  1.00 46.99  ? 117 VAL A O   1 
ATOM   568  C  CB  . VAL A 1 117 ? 123.584 104.416 97.024  1.00 36.50  ? 117 VAL A CB  1 
ATOM   569  C  CG1 . VAL A 1 117 ? 124.251 104.671 98.363  1.00 41.84  ? 117 VAL A CG1 1 
ATOM   570  C  CG2 . VAL A 1 117 ? 122.139 104.880 97.024  1.00 35.99  ? 117 VAL A CG2 1 
ATOM   571  N  N   . TRP A 1 118 ? 123.129 105.531 93.826  1.00 45.51  ? 118 TRP A N   1 
ATOM   572  C  CA  . TRP A 1 118 ? 122.444 105.165 92.594  1.00 42.97  ? 118 TRP A CA  1 
ATOM   573  C  C   . TRP A 1 118 ? 123.350 105.235 91.374  1.00 44.79  ? 118 TRP A C   1 
ATOM   574  O  O   . TRP A 1 118 ? 122.862 105.402 90.250  1.00 54.07  ? 118 TRP A O   1 
ATOM   575  C  CB  . TRP A 1 118 ? 121.199 106.032 92.409  1.00 34.42  ? 118 TRP A CB  1 
ATOM   576  C  CG  . TRP A 1 118 ? 120.097 105.617 93.332  1.00 42.69  ? 118 TRP A CG  1 
ATOM   577  C  CD1 . TRP A 1 118 ? 119.568 106.342 94.356  1.00 41.05  ? 118 TRP A CD1 1 
ATOM   578  C  CD2 . TRP A 1 118 ? 119.411 104.359 93.333  1.00 42.51  ? 118 TRP A CD2 1 
ATOM   579  N  NE1 . TRP A 1 118 ? 118.587 105.620 94.989  1.00 47.91  ? 118 TRP A NE1 1 
ATOM   580  C  CE2 . TRP A 1 118 ? 118.471 104.399 94.379  1.00 43.51  ? 118 TRP A CE2 1 
ATOM   581  C  CE3 . TRP A 1 118 ? 119.496 103.206 92.547  1.00 39.14  ? 118 TRP A CE3 1 
ATOM   582  C  CZ2 . TRP A 1 118 ? 117.622 103.331 94.660  1.00 39.10  ? 118 TRP A CZ2 1 
ATOM   583  C  CZ3 . TRP A 1 118 ? 118.653 102.148 92.827  1.00 41.61  ? 118 TRP A CZ3 1 
ATOM   584  C  CH2 . TRP A 1 118 ? 117.728 102.218 93.874  1.00 37.85  ? 118 TRP A CH2 1 
ATOM   585  N  N   . ARG A 1 119 ? 124.664 105.119 91.571  1.00 44.26  ? 119 ARG A N   1 
ATOM   586  C  CA  . ARG A 1 119 ? 125.552 104.773 90.472  1.00 38.84  ? 119 ARG A CA  1 
ATOM   587  C  C   . ARG A 1 119 ? 125.337 103.338 90.018  1.00 43.83  ? 119 ARG A C   1 
ATOM   588  O  O   . ARG A 1 119 ? 125.759 102.975 88.916  1.00 56.93  ? 119 ARG A O   1 
ATOM   589  C  CB  . ARG A 1 119 ? 127.009 104.973 90.888  1.00 46.56  ? 119 ARG A CB  1 
ATOM   590  C  CG  . ARG A 1 119 ? 127.303 106.326 91.503  1.00 50.68  ? 119 ARG A CG  1 
ATOM   591  C  CD  . ARG A 1 119 ? 128.609 106.301 92.281  1.00 53.61  ? 119 ARG A CD  1 
ATOM   592  N  NE  . ARG A 1 119 ? 129.428 107.478 92.020  1.00 62.66  ? 119 ARG A NE  1 
ATOM   593  C  CZ  . ARG A 1 119 ? 129.297 108.636 92.651  1.00 62.88  ? 119 ARG A CZ  1 
ATOM   594  N  NH1 . ARG A 1 119 ? 128.373 108.816 93.580  1.00 57.94  ? 119 ARG A NH1 1 
ATOM   595  N  NH2 . ARG A 1 119 ? 130.112 109.640 92.341  1.00 58.88  ? 119 ARG A NH2 1 
ATOM   596  N  N   . ILE A 1 120 ? 124.698 102.517 90.854  1.00 43.57  ? 120 ILE A N   1 
ATOM   597  C  CA  . ILE A 1 120 ? 124.370 101.147 90.479  1.00 40.97  ? 120 ILE A CA  1 
ATOM   598  C  C   . ILE A 1 120 ? 123.361 101.133 89.337  1.00 50.09  ? 120 ILE A C   1 
ATOM   599  O  O   . ILE A 1 120 ? 123.389 100.248 88.475  1.00 55.92  ? 120 ILE A O   1 
ATOM   600  C  CB  . ILE A 1 120 ? 123.865 100.374 91.714  1.00 47.20  ? 120 ILE A CB  1 
ATOM   601  C  CG1 . ILE A 1 120 ? 123.754 98.879  91.422  1.00 46.92  ? 120 ILE A CG1 1 
ATOM   602  C  CG2 . ILE A 1 120 ? 122.541 100.935 92.221  1.00 43.29  ? 120 ILE A CG2 1 
ATOM   603  C  CD1 . ILE A 1 120 ? 123.456 98.052  92.651  1.00 41.48  ? 120 ILE A CD1 1 
ATOM   604  N  N   . SER A 1 121 ? 122.454 102.106 89.317  1.00 56.70  ? 121 SER A N   1 
ATOM   605  C  CA  . SER A 1 121 ? 121.486 102.260 88.232  1.00 45.46  ? 121 SER A CA  1 
ATOM   606  C  C   . SER A 1 121 ? 121.147 103.739 88.150  1.00 53.09  ? 121 SER A C   1 
ATOM   607  O  O   . SER A 1 121 ? 120.334 104.246 88.937  1.00 60.45  ? 121 SER A O   1 
ATOM   608  C  CB  . SER A 1 121 ? 120.232 101.419 88.457  1.00 48.10  ? 121 SER A CB  1 
ATOM   609  O  OG  . SER A 1 121 ? 120.537 100.038 88.429  1.00 56.16  ? 121 SER A OG  1 
ATOM   610  N  N   . PRO A 1 122 ? 121.757 104.472 87.215  1.00 55.31  ? 122 PRO A N   1 
ATOM   611  C  CA  . PRO A 1 122 ? 121.568 105.931 87.181  1.00 46.11  ? 122 PRO A CA  1 
ATOM   612  C  C   . PRO A 1 122 ? 120.137 106.370 86.926  1.00 53.02  ? 122 PRO A C   1 
ATOM   613  O  O   . PRO A 1 122 ? 119.808 107.532 87.191  1.00 66.93  ? 122 PRO A O   1 
ATOM   614  C  CB  . PRO A 1 122 ? 122.497 106.373 86.043  1.00 51.65  ? 122 PRO A CB  1 
ATOM   615  C  CG  . PRO A 1 122 ? 123.529 105.296 85.971  1.00 48.58  ? 122 PRO A CG  1 
ATOM   616  C  CD  . PRO A 1 122 ? 122.782 104.031 86.256  1.00 51.12  ? 122 PRO A CD  1 
ATOM   617  N  N   . MET A 1 123 ? 119.276 105.488 86.425  1.00 54.44  ? 123 MET A N   1 
ATOM   618  C  CA  . MET A 1 123 ? 117.910 105.854 86.078  1.00 50.06  ? 123 MET A CA  1 
ATOM   619  C  C   . MET A 1 123 ? 116.960 105.835 87.270  1.00 57.45  ? 123 MET A C   1 
ATOM   620  O  O   . MET A 1 123 ? 115.777 106.150 87.099  1.00 58.87  ? 123 MET A O   1 
ATOM   621  C  CB  . MET A 1 123 ? 117.387 104.917 84.985  1.00 53.23  ? 123 MET A CB  1 
ATOM   622  C  CG  . MET A 1 123 ? 116.366 105.544 84.051  1.00 60.67  ? 123 MET A CG  1 
ATOM   623  S  SD  . MET A 1 123 ? 115.600 104.338 82.953  1.00 75.94  ? 123 MET A SD  1 
ATOM   624  C  CE  . MET A 1 123 ? 114.357 103.635 84.031  1.00 55.91  ? 123 MET A CE  1 
ATOM   625  N  N   . PHE A 1 124 ? 117.436 105.485 88.466  1.00 49.84  ? 124 PHE A N   1 
ATOM   626  C  CA  . PHE A 1 124 ? 116.580 105.353 89.640  1.00 41.13  ? 124 PHE A CA  1 
ATOM   627  C  C   . PHE A 1 124 ? 116.962 106.329 90.751  1.00 49.29  ? 124 PHE A C   1 
ATOM   628  O  O   . PHE A 1 124 ? 116.848 106.003 91.933  1.00 56.22  ? 124 PHE A O   1 
ATOM   629  C  CB  . PHE A 1 124 ? 116.606 103.918 90.165  1.00 34.70  ? 124 PHE A CB  1 
ATOM   630  C  CG  . PHE A 1 124 ? 115.835 102.947 89.318  1.00 49.47  ? 124 PHE A CG  1 
ATOM   631  C  CD1 . PHE A 1 124 ? 114.479 102.758 89.520  1.00 48.72  ? 124 PHE A CD1 1 
ATOM   632  C  CD2 . PHE A 1 124 ? 116.465 102.218 88.325  1.00 53.57  ? 124 PHE A CD2 1 
ATOM   633  C  CE1 . PHE A 1 124 ? 113.766 101.865 88.745  1.00 45.73  ? 124 PHE A CE1 1 
ATOM   634  C  CE2 . PHE A 1 124 ? 115.757 101.323 87.547  1.00 46.96  ? 124 PHE A CE2 1 
ATOM   635  C  CZ  . PHE A 1 124 ? 114.405 101.148 87.757  1.00 44.91  ? 124 PHE A CZ  1 
ATOM   636  N  N   . LYS A 1 125 ? 117.409 107.535 90.392  1.00 48.77  ? 125 LYS A N   1 
ATOM   637  C  CA  . LYS A 1 125 ? 117.691 108.565 91.388  1.00 48.73  ? 125 LYS A CA  1 
ATOM   638  C  C   . LYS A 1 125 ? 116.419 109.184 91.960  1.00 49.19  ? 125 LYS A C   1 
ATOM   639  O  O   . LYS A 1 125 ? 116.477 109.870 92.994  1.00 58.15  ? 125 LYS A O   1 
ATOM   640  C  CB  . LYS A 1 125 ? 118.578 109.645 90.770  1.00 47.04  ? 125 LYS A CB  1 
ATOM   641  C  CG  . LYS A 1 125 ? 119.661 110.175 91.688  1.00 46.05  ? 125 LYS A CG  1 
ATOM   642  C  CD  . LYS A 1 125 ? 120.432 111.299 91.023  1.00 44.93  ? 125 LYS A CD  1 
ATOM   643  C  CE  . LYS A 1 125 ? 121.439 111.915 91.974  1.00 51.74  ? 125 LYS A CE  1 
ATOM   644  N  NZ  . LYS A 1 125 ? 122.709 112.259 91.282  1.00 56.10  ? 125 LYS A NZ  1 
ATOM   645  N  N   . GLY A 1 126 ? 115.275 108.951 91.314  1.00 39.84  ? 126 GLY A N   1 
ATOM   646  C  CA  . GLY A 1 126 ? 114.015 109.401 91.869  1.00 37.95  ? 126 GLY A CA  1 
ATOM   647  C  C   . GLY A 1 126 ? 113.709 108.776 93.214  1.00 41.32  ? 126 GLY A C   1 
ATOM   648  O  O   . GLY A 1 126 ? 112.964 109.348 94.007  1.00 54.02  ? 126 GLY A O   1 
ATOM   649  N  N   . VAL A 1 127 ? 114.289 107.608 93.496  1.00 34.91  ? 127 VAL A N   1 
ATOM   650  C  CA  . VAL A 1 127 ? 114.122 106.991 94.810  1.00 43.41  ? 127 VAL A CA  1 
ATOM   651  C  C   . VAL A 1 127 ? 114.718 107.883 95.894  1.00 44.52  ? 127 VAL A C   1 
ATOM   652  O  O   . VAL A 1 127 ? 114.066 108.195 96.899  1.00 54.86  ? 127 VAL A O   1 
ATOM   653  C  CB  . VAL A 1 127 ? 114.749 105.585 94.823  1.00 40.11  ? 127 VAL A CB  1 
ATOM   654  C  CG1 . VAL A 1 127 ? 114.646 104.967 96.203  1.00 43.35  ? 127 VAL A CG1 1 
ATOM   655  C  CG2 . VAL A 1 127 ? 114.081 104.696 93.788  1.00 34.55  ? 127 VAL A CG2 1 
ATOM   656  N  N   . GLY A 1 128 ? 115.961 108.325 95.693  1.00 35.72  ? 128 GLY A N   1 
ATOM   657  C  CA  . GLY A 1 128 ? 116.577 109.230 96.650  1.00 38.15  ? 128 GLY A CA  1 
ATOM   658  C  C   . GLY A 1 128 ? 115.876 110.573 96.719  1.00 45.47  ? 128 GLY A C   1 
ATOM   659  O  O   . GLY A 1 128 ? 115.737 111.159 97.798  1.00 59.34  ? 128 GLY A O   1 
ATOM   660  N  N   . TYR A 1 129 ? 115.425 111.082 95.570  1.00 40.28  ? 129 TYR A N   1 
ATOM   661  C  CA  . TYR A 1 129 ? 114.712 112.359 95.585  1.00 35.74  ? 129 TYR A CA  1 
ATOM   662  C  C   . TYR A 1 129 ? 113.398 112.258 96.362  1.00 38.95  ? 129 TYR A C   1 
ATOM   663  O  O   . TYR A 1 129 ? 113.050 113.166 97.130  1.00 48.73  ? 129 TYR A O   1 
ATOM   664  C  CB  . TYR A 1 129 ? 114.476 112.844 94.157  1.00 41.35  ? 129 TYR A CB  1 
ATOM   665  C  CG  . TYR A 1 129 ? 115.715 113.447 93.535  1.00 37.95  ? 129 TYR A CG  1 
ATOM   666  C  CD1 . TYR A 1 129 ? 116.456 114.405 94.210  1.00 37.42  ? 129 TYR A CD1 1 
ATOM   667  C  CD2 . TYR A 1 129 ? 116.150 113.050 92.279  1.00 46.15  ? 129 TYR A CD2 1 
ATOM   668  C  CE1 . TYR A 1 129 ? 117.591 114.955 93.652  1.00 39.67  ? 129 TYR A CE1 1 
ATOM   669  C  CE2 . TYR A 1 129 ? 117.285 113.595 91.712  1.00 45.94  ? 129 TYR A CE2 1 
ATOM   670  C  CZ  . TYR A 1 129 ? 118.001 114.547 92.403  1.00 46.46  ? 129 TYR A CZ  1 
ATOM   671  O  OH  . TYR A 1 129 ? 119.130 115.094 91.843  1.00 46.35  ? 129 TYR A OH  1 
ATOM   672  N  N   . GLY A 1 130 ? 112.663 111.158 96.190  1.00 33.91  ? 130 GLY A N   1 
ATOM   673  C  CA  . GLY A 1 130 ? 111.462 110.949 96.981  1.00 37.92  ? 130 GLY A CA  1 
ATOM   674  C  C   . GLY A 1 130 ? 111.760 110.777 98.456  1.00 45.08  ? 130 GLY A C   1 
ATOM   675  O  O   . GLY A 1 130 ? 110.984 111.212 99.311  1.00 51.64  ? 130 GLY A O   1 
ATOM   676  N  N   . MET A 1 131 ? 112.888 110.138 98.775  1.00 39.20  ? 131 MET A N   1 
ATOM   677  C  CA  . MET A 1 131 ? 113.311 110.040 100.169 1.00 34.89  ? 131 MET A CA  1 
ATOM   678  C  C   . MET A 1 131 ? 113.513 111.425 100.773 1.00 42.50  ? 131 MET A C   1 
ATOM   679  O  O   . MET A 1 131 ? 113.076 111.698 101.898 1.00 50.20  ? 131 MET A O   1 
ATOM   680  C  CB  . MET A 1 131 ? 114.596 109.219 100.270 1.00 34.53  ? 131 MET A CB  1 
ATOM   681  C  CG  . MET A 1 131 ? 114.384 107.718 100.257 1.00 40.48  ? 131 MET A CG  1 
ATOM   682  S  SD  . MET A 1 131 ? 115.940 106.814 100.300 1.00 54.54  ? 131 MET A SD  1 
ATOM   683  C  CE  . MET A 1 131 ? 115.351 105.126 100.285 1.00 46.90  ? 131 MET A CE  1 
ATOM   684  N  N   . MET A 1 132 ? 114.170 112.318 100.028 1.00 41.51  ? 132 MET A N   1 
ATOM   685  C  CA  . MET A 1 132 ? 114.363 113.685 100.510 1.00 42.08  ? 132 MET A CA  1 
ATOM   686  C  C   . MET A 1 132 ? 113.035 114.414 100.684 1.00 43.36  ? 132 MET A C   1 
ATOM   687  O  O   . MET A 1 132 ? 112.847 115.157 101.657 1.00 48.14  ? 132 MET A O   1 
ATOM   688  C  CB  . MET A 1 132 ? 115.271 114.462 99.558  1.00 40.43  ? 132 MET A CB  1 
ATOM   689  C  CG  . MET A 1 132 ? 116.600 113.799 99.278  1.00 48.67  ? 132 MET A CG  1 
ATOM   690  S  SD  . MET A 1 132 ? 117.971 114.929 99.553  1.00 79.59  ? 132 MET A SD  1 
ATOM   691  C  CE  . MET A 1 132 ? 117.890 115.926 98.069  1.00 52.15  ? 132 MET A CE  1 
ATOM   692  N  N   . VAL A 1 133 ? 112.107 114.228 99.742  1.00 38.99  ? 133 VAL A N   1 
ATOM   693  C  CA  . VAL A 1 133 ? 110.802 114.883 99.846  1.00 36.81  ? 133 VAL A CA  1 
ATOM   694  C  C   . VAL A 1 133 ? 110.069 114.418 101.102 1.00 36.94  ? 133 VAL A C   1 
ATOM   695  O  O   . VAL A 1 133 ? 109.502 115.225 101.854 1.00 41.32  ? 133 VAL A O   1 
ATOM   696  C  CB  . VAL A 1 133 ? 109.970 114.626 98.577  1.00 27.84  ? 133 VAL A CB  1 
ATOM   697  C  CG1 . VAL A 1 133 ? 108.548 115.113 98.765  1.00 38.84  ? 133 VAL A CG1 1 
ATOM   698  C  CG2 . VAL A 1 133 ? 110.608 115.304 97.381  1.00 28.06  ? 133 VAL A CG2 1 
ATOM   699  N  N   . VAL A 1 134 ? 110.078 113.106 101.351 1.00 34.37  ? 134 VAL A N   1 
ATOM   700  C  CA  . VAL A 1 134 ? 109.422 112.566 102.540 1.00 36.86  ? 134 VAL A CA  1 
ATOM   701  C  C   . VAL A 1 134 ? 110.081 113.101 103.804 1.00 37.30  ? 134 VAL A C   1 
ATOM   702  O  O   . VAL A 1 134 ? 109.402 113.431 104.786 1.00 41.44  ? 134 VAL A O   1 
ATOM   703  C  CB  . VAL A 1 134 ? 109.431 111.026 102.506 1.00 41.40  ? 134 VAL A CB  1 
ATOM   704  C  CG1 . VAL A 1 134 ? 108.918 110.468 103.817 1.00 48.69  ? 134 VAL A CG1 1 
ATOM   705  C  CG2 . VAL A 1 134 ? 108.586 110.517 101.360 1.00 39.43  ? 134 VAL A CG2 1 
ATOM   706  N  N   . SER A 1 135 ? 111.414 113.185 103.806 1.00 35.27  ? 135 SER A N   1 
ATOM   707  C  CA  . SER A 1 135 ? 112.120 113.709 104.971 1.00 37.01  ? 135 SER A CA  1 
ATOM   708  C  C   . SER A 1 135 ? 111.720 115.151 105.260 1.00 42.37  ? 135 SER A C   1 
ATOM   709  O  O   . SER A 1 135 ? 111.506 115.523 106.420 1.00 51.18  ? 135 SER A O   1 
ATOM   710  C  CB  . SER A 1 135 ? 113.628 113.598 104.757 1.00 31.83  ? 135 SER A CB  1 
ATOM   711  O  OG  . SER A 1 135 ? 114.320 114.599 105.478 1.00 52.45  ? 135 SER A OG  1 
ATOM   712  N  N   . THR A 1 136 ? 111.612 115.977 104.217 1.00 34.84  ? 136 THR A N   1 
ATOM   713  C  CA  . THR A 1 136 ? 111.174 117.359 104.405 1.00 30.52  ? 136 THR A CA  1 
ATOM   714  C  C   . THR A 1 136 ? 109.762 117.416 104.983 1.00 35.30  ? 136 THR A C   1 
ATOM   715  O  O   . THR A 1 136 ? 109.489 118.168 105.934 1.00 44.15  ? 136 THR A O   1 
ATOM   716  C  CB  . THR A 1 136 ? 111.239 118.110 103.073 1.00 31.73  ? 136 THR A CB  1 
ATOM   717  O  OG1 . THR A 1 136 ? 112.577 118.073 102.566 1.00 41.32  ? 136 THR A OG1 1 
ATOM   718  C  CG2 . THR A 1 136 ? 110.811 119.555 103.248 1.00 39.80  ? 136 THR A CG2 1 
ATOM   719  N  N   . TYR A 1 137 ? 108.854 116.609 104.424 1.00 43.38  ? 137 TYR A N   1 
ATOM   720  C  CA  . TYR A 1 137 ? 107.477 116.588 104.913 1.00 37.46  ? 137 TYR A CA  1 
ATOM   721  C  C   . TYR A 1 137 ? 107.426 116.224 106.391 1.00 39.27  ? 137 TYR A C   1 
ATOM   722  O  O   . TYR A 1 137 ? 106.713 116.860 107.175 1.00 39.22  ? 137 TYR A O   1 
ATOM   723  C  CB  . TYR A 1 137 ? 106.640 115.603 104.096 1.00 38.68  ? 137 TYR A CB  1 
ATOM   724  C  CG  . TYR A 1 137 ? 106.003 116.193 102.860 1.00 41.40  ? 137 TYR A CG  1 
ATOM   725  C  CD1 . TYR A 1 137 ? 105.320 117.399 102.913 1.00 42.46  ? 137 TYR A CD1 1 
ATOM   726  C  CD2 . TYR A 1 137 ? 106.075 115.536 101.640 1.00 45.85  ? 137 TYR A CD2 1 
ATOM   727  C  CE1 . TYR A 1 137 ? 104.735 117.937 101.786 1.00 42.12  ? 137 TYR A CE1 1 
ATOM   728  C  CE2 . TYR A 1 137 ? 105.493 116.065 100.509 1.00 41.91  ? 137 TYR A CE2 1 
ATOM   729  C  CZ  . TYR A 1 137 ? 104.825 117.265 100.587 1.00 45.45  ? 137 TYR A CZ  1 
ATOM   730  O  OH  . TYR A 1 137 ? 104.244 117.795 99.459  1.00 51.37  ? 137 TYR A OH  1 
ATOM   731  N  N   . ILE A 1 138 ? 108.178 115.195 106.789 1.00 36.14  ? 138 ILE A N   1 
ATOM   732  C  CA  . ILE A 1 138 ? 108.166 114.762 108.185 1.00 39.17  ? 138 ILE A CA  1 
ATOM   733  C  C   . ILE A 1 138 ? 108.755 115.838 109.090 1.00 39.87  ? 138 ILE A C   1 
ATOM   734  O  O   . ILE A 1 138 ? 108.196 116.152 110.152 1.00 45.92  ? 138 ILE A O   1 
ATOM   735  C  CB  . ILE A 1 138 ? 108.914 113.425 108.336 1.00 35.81  ? 138 ILE A CB  1 
ATOM   736  C  CG1 . ILE A 1 138 ? 108.183 112.322 107.572 1.00 41.77  ? 138 ILE A CG1 1 
ATOM   737  C  CG2 . ILE A 1 138 ? 109.052 113.051 109.801 1.00 32.84  ? 138 ILE A CG2 1 
ATOM   738  C  CD1 . ILE A 1 138 ? 108.805 110.959 107.722 1.00 31.91  ? 138 ILE A CD1 1 
ATOM   739  N  N   . GLY A 1 139 ? 109.882 116.425 108.678 1.00 34.05  ? 139 GLY A N   1 
ATOM   740  C  CA  . GLY A 1 139 ? 110.567 117.382 109.525 1.00 28.38  ? 139 GLY A CA  1 
ATOM   741  C  C   . GLY A 1 139 ? 109.825 118.689 109.691 1.00 35.31  ? 139 GLY A C   1 
ATOM   742  O  O   . GLY A 1 139 ? 110.124 119.457 110.609 1.00 45.12  ? 139 GLY A O   1 
ATOM   743  N  N   . ILE A 1 140 ? 108.867 118.977 108.807 1.00 42.78  ? 140 ILE A N   1 
ATOM   744  C  CA  . ILE A 1 140 ? 108.062 120.186 108.994 1.00 32.10  ? 140 ILE A CA  1 
ATOM   745  C  C   . ILE A 1 140 ? 107.248 120.107 110.287 1.00 35.92  ? 140 ILE A C   1 
ATOM   746  O  O   . ILE A 1 140 ? 107.218 121.059 111.075 1.00 50.12  ? 140 ILE A O   1 
ATOM   747  C  CB  . ILE A 1 140 ? 107.166 120.444 107.770 1.00 46.63  ? 140 ILE A CB  1 
ATOM   748  C  CG1 . ILE A 1 140 ? 107.988 121.051 106.633 1.00 40.49  ? 140 ILE A CG1 1 
ATOM   749  C  CG2 . ILE A 1 140 ? 106.028 121.384 108.130 1.00 38.12  ? 140 ILE A CG2 1 
ATOM   750  C  CD1 . ILE A 1 140 ? 107.275 121.071 105.302 1.00 36.38  ? 140 ILE A CD1 1 
ATOM   751  N  N   . TYR A 1 141 ? 106.585 118.972 110.538 1.00 35.15  ? 141 TYR A N   1 
ATOM   752  C  CA  . TYR A 1 141 ? 105.672 118.859 111.676 1.00 40.98  ? 141 TYR A CA  1 
ATOM   753  C  C   . TYR A 1 141 ? 106.265 118.132 112.883 1.00 42.52  ? 141 TYR A C   1 
ATOM   754  O  O   . TYR A 1 141 ? 105.687 118.205 113.984 1.00 43.38  ? 141 TYR A O   1 
ATOM   755  C  CB  . TYR A 1 141 ? 104.361 118.178 111.242 1.00 39.39  ? 141 TYR A CB  1 
ATOM   756  C  CG  . TYR A 1 141 ? 104.432 116.681 111.011 1.00 45.61  ? 141 TYR A CG  1 
ATOM   757  C  CD1 . TYR A 1 141 ? 104.256 115.784 112.057 1.00 44.82  ? 141 TYR A CD1 1 
ATOM   758  C  CD2 . TYR A 1 141 ? 104.647 116.166 109.740 1.00 45.00  ? 141 TYR A CD2 1 
ATOM   759  C  CE1 . TYR A 1 141 ? 104.313 114.422 111.848 1.00 40.26  ? 141 TYR A CE1 1 
ATOM   760  C  CE2 . TYR A 1 141 ? 104.705 114.804 109.523 1.00 41.49  ? 141 TYR A CE2 1 
ATOM   761  C  CZ  . TYR A 1 141 ? 104.538 113.938 110.580 1.00 44.43  ? 141 TYR A CZ  1 
ATOM   762  O  OH  . TYR A 1 141 ? 104.592 112.582 110.370 1.00 42.73  ? 141 TYR A OH  1 
ATOM   763  N  N   . TYR A 1 142 ? 107.400 117.445 112.716 1.00 36.19  ? 142 TYR A N   1 
ATOM   764  C  CA  . TYR A 1 142 ? 108.077 116.871 113.874 1.00 35.97  ? 142 TYR A CA  1 
ATOM   765  C  C   . TYR A 1 142 ? 108.412 117.949 114.898 1.00 44.48  ? 142 TYR A C   1 
ATOM   766  O  O   . TYR A 1 142 ? 108.227 117.756 116.108 1.00 49.86  ? 142 TYR A O   1 
ATOM   767  C  CB  . TYR A 1 142 ? 109.342 116.144 113.421 1.00 38.72  ? 142 TYR A CB  1 
ATOM   768  C  CG  . TYR A 1 142 ? 109.700 114.921 114.231 1.00 40.38  ? 142 TYR A CG  1 
ATOM   769  C  CD1 . TYR A 1 142 ? 109.086 113.701 113.991 1.00 36.26  ? 142 TYR A CD1 1 
ATOM   770  C  CD2 . TYR A 1 142 ? 110.669 114.983 115.222 1.00 38.76  ? 142 TYR A CD2 1 
ATOM   771  C  CE1 . TYR A 1 142 ? 109.417 112.580 114.724 1.00 39.56  ? 142 TYR A CE1 1 
ATOM   772  C  CE2 . TYR A 1 142 ? 111.007 113.868 115.958 1.00 40.54  ? 142 TYR A CE2 1 
ATOM   773  C  CZ  . TYR A 1 142 ? 110.379 112.670 115.705 1.00 43.85  ? 142 TYR A CZ  1 
ATOM   774  O  OH  . TYR A 1 142 ? 110.715 111.557 116.438 1.00 53.06  ? 142 TYR A OH  1 
ATOM   775  N  N   . ASN A 1 143 ? 108.881 119.106 114.427 1.00 46.28  ? 143 ASN A N   1 
ATOM   776  C  CA  . ASN A 1 143 ? 109.221 120.187 115.342 1.00 39.52  ? 143 ASN A CA  1 
ATOM   777  C  C   . ASN A 1 143 ? 107.982 120.810 115.971 1.00 41.97  ? 143 ASN A C   1 
ATOM   778  O  O   . ASN A 1 143 ? 108.062 121.345 117.077 1.00 44.65  ? 143 ASN A O   1 
ATOM   779  C  CB  . ASN A 1 143 ? 110.051 121.245 114.620 1.00 37.63  ? 143 ASN A CB  1 
ATOM   780  C  CG  . ASN A 1 143 ? 111.380 121.499 115.300 1.00 45.58  ? 143 ASN A CG  1 
ATOM   781  O  OD1 . ASN A 1 143 ? 111.453 121.590 116.523 1.00 55.48  ? 143 ASN A OD1 1 
ATOM   782  N  ND2 . ASN A 1 143 ? 112.440 121.603 114.513 1.00 52.77  ? 143 ASN A ND2 1 
ATOM   783  N  N   . VAL A 1 144 ? 106.830 120.747 115.301 1.00 41.54  ? 144 VAL A N   1 
ATOM   784  C  CA  . VAL A 1 144 ? 105.594 121.205 115.930 1.00 38.55  ? 144 VAL A CA  1 
ATOM   785  C  C   . VAL A 1 144 ? 105.226 120.300 117.101 1.00 36.24  ? 144 VAL A C   1 
ATOM   786  O  O   . VAL A 1 144 ? 104.811 120.773 118.170 1.00 37.69  ? 144 VAL A O   1 
ATOM   787  C  CB  . VAL A 1 144 ? 104.460 121.286 114.893 1.00 44.78  ? 144 VAL A CB  1 
ATOM   788  C  CG1 . VAL A 1 144 ? 103.156 121.689 115.563 1.00 38.69  ? 144 VAL A CG1 1 
ATOM   789  C  CG2 . VAL A 1 144 ? 104.819 122.272 113.795 1.00 40.37  ? 144 VAL A CG2 1 
ATOM   790  N  N   . VAL A 1 145 ? 105.371 118.986 116.922 1.00 43.48  ? 145 VAL A N   1 
ATOM   791  C  CA  . VAL A 1 145 ? 105.135 118.080 118.048 1.00 42.55  ? 145 VAL A CA  1 
ATOM   792  C  C   . VAL A 1 145 ? 106.127 118.359 119.178 1.00 42.21  ? 145 VAL A C   1 
ATOM   793  O  O   . VAL A 1 145 ? 105.760 118.375 120.365 1.00 40.26  ? 145 VAL A O   1 
ATOM   794  C  CB  . VAL A 1 145 ? 105.193 116.614 117.584 1.00 39.55  ? 145 VAL A CB  1 
ATOM   795  C  CG1 . VAL A 1 145 ? 104.845 115.682 118.732 1.00 30.52  ? 145 VAL A CG1 1 
ATOM   796  C  CG2 . VAL A 1 145 ? 104.247 116.390 116.420 1.00 35.55  ? 145 VAL A CG2 1 
ATOM   797  N  N   . ILE A 1 146 ? 107.394 118.595 118.828 1.00 33.48  ? 146 ILE A N   1 
ATOM   798  C  CA  . ILE A 1 146 ? 108.404 118.906 119.840 1.00 29.70  ? 146 ILE A CA  1 
ATOM   799  C  C   . ILE A 1 146 ? 108.060 120.200 120.572 1.00 43.56  ? 146 ILE A C   1 
ATOM   800  O  O   . ILE A 1 146 ? 108.284 120.324 121.780 1.00 55.18  ? 146 ILE A O   1 
ATOM   801  C  CB  . ILE A 1 146 ? 109.804 118.969 119.200 1.00 39.10  ? 146 ILE A CB  1 
ATOM   802  C  CG1 . ILE A 1 146 ? 110.205 117.600 118.653 1.00 41.83  ? 146 ILE A CG1 1 
ATOM   803  C  CG2 . ILE A 1 146 ? 110.838 119.445 120.207 1.00 33.81  ? 146 ILE A CG2 1 
ATOM   804  C  CD1 . ILE A 1 146 ? 111.519 117.608 117.917 1.00 39.58  ? 146 ILE A CD1 1 
ATOM   805  N  N   . CYS A 1 147 ? 107.513 121.186 119.858 1.00 39.81  ? 147 CYS A N   1 
ATOM   806  C  CA  . CYS A 1 147 ? 107.137 122.445 120.493 1.00 31.29  ? 147 CYS A CA  1 
ATOM   807  C  C   . CYS A 1 147 ? 105.935 122.290 121.413 1.00 31.31  ? 147 CYS A C   1 
ATOM   808  O  O   . CYS A 1 147 ? 105.868 122.969 122.443 1.00 42.94  ? 147 CYS A O   1 
ATOM   809  C  CB  . CYS A 1 147 ? 106.853 123.512 119.435 1.00 32.57  ? 147 CYS A CB  1 
ATOM   810  S  SG  . CYS A 1 147 ? 105.618 123.063 118.197 1.00 48.02  ? 147 CYS A SG  1 
ATOM   811  N  N   . ILE A 1 148 ? 104.984 121.419 121.070 1.00 39.29  ? 148 ILE A N   1 
ATOM   812  C  CA  . ILE A 1 148 ? 103.909 121.113 122.012 1.00 38.09  ? 148 ILE A CA  1 
ATOM   813  C  C   . ILE A 1 148 ? 104.481 120.476 123.276 1.00 38.77  ? 148 ILE A C   1 
ATOM   814  O  O   . ILE A 1 148 ? 104.065 120.799 124.400 1.00 40.68  ? 148 ILE A O   1 
ATOM   815  C  CB  . ILE A 1 148 ? 102.847 120.215 121.352 1.00 41.77  ? 148 ILE A CB  1 
ATOM   816  C  CG1 . ILE A 1 148 ? 102.080 120.990 120.281 1.00 38.40  ? 148 ILE A CG1 1 
ATOM   817  C  CG2 . ILE A 1 148 ? 101.882 119.673 122.391 1.00 32.74  ? 148 ILE A CG2 1 
ATOM   818  C  CD1 . ILE A 1 148 ? 101.200 120.118 119.417 1.00 35.97  ? 148 ILE A CD1 1 
ATOM   819  N  N   . ALA A 1 149 ? 105.448 119.569 123.114 1.00 42.06  ? 149 ALA A N   1 
ATOM   820  C  CA  . ALA A 1 149 ? 106.115 118.994 124.282 1.00 32.86  ? 149 ALA A CA  1 
ATOM   821  C  C   . ALA A 1 149 ? 106.821 120.070 125.104 1.00 43.51  ? 149 ALA A C   1 
ATOM   822  O  O   . ALA A 1 149 ? 106.804 120.030 126.340 1.00 43.78  ? 149 ALA A O   1 
ATOM   823  C  CB  . ALA A 1 149 ? 107.104 117.914 123.847 1.00 32.71  ? 149 ALA A CB  1 
ATOM   824  N  N   . PHE A 1 150 ? 107.454 121.034 124.432 1.00 52.46  ? 150 PHE A N   1 
ATOM   825  C  CA  . PHE A 1 150 ? 108.097 122.150 125.124 1.00 39.22  ? 150 PHE A CA  1 
ATOM   826  C  C   . PHE A 1 150 ? 107.084 122.954 125.930 1.00 44.09  ? 150 PHE A C   1 
ATOM   827  O  O   . PHE A 1 150 ? 107.350 123.349 127.071 1.00 43.94  ? 150 PHE A O   1 
ATOM   828  C  CB  . PHE A 1 150 ? 108.799 123.059 124.114 1.00 38.72  ? 150 PHE A CB  1 
ATOM   829  C  CG  . PHE A 1 150 ? 110.294 122.929 124.104 1.00 49.82  ? 150 PHE A CG  1 
ATOM   830  C  CD1 . PHE A 1 150 ? 111.047 123.365 125.180 1.00 47.19  ? 150 PHE A CD1 1 
ATOM   831  C  CD2 . PHE A 1 150 ? 110.948 122.393 123.009 1.00 41.76  ? 150 PHE A CD2 1 
ATOM   832  C  CE1 . PHE A 1 150 ? 112.423 123.254 125.169 1.00 48.96  ? 150 PHE A CE1 1 
ATOM   833  C  CE2 . PHE A 1 150 ? 112.322 122.280 122.992 1.00 42.43  ? 150 PHE A CE2 1 
ATOM   834  C  CZ  . PHE A 1 150 ? 113.061 122.711 124.072 1.00 50.79  ? 150 PHE A CZ  1 
ATOM   835  N  N   . TYR A 1 151 ? 105.920 123.223 125.336 1.00 48.08  ? 151 TYR A N   1 
ATOM   836  C  CA  . TYR A 1 151 ? 104.882 123.970 126.039 1.00 41.41  ? 151 TYR A CA  1 
ATOM   837  C  C   . TYR A 1 151 ? 104.414 123.222 127.277 1.00 46.37  ? 151 TYR A C   1 
ATOM   838  O  O   . TYR A 1 151 ? 104.198 123.827 128.333 1.00 50.88  ? 151 TYR A O   1 
ATOM   839  C  CB  . TYR A 1 151 ? 103.705 124.248 125.103 1.00 47.72  ? 151 TYR A CB  1 
ATOM   840  C  CG  . TYR A 1 151 ? 102.565 125.007 125.749 1.00 47.37  ? 151 TYR A CG  1 
ATOM   841  C  CD1 . TYR A 1 151 ? 101.523 124.339 126.376 1.00 45.78  ? 151 TYR A CD1 1 
ATOM   842  C  CD2 . TYR A 1 151 ? 102.534 126.393 125.733 1.00 47.47  ? 151 TYR A CD2 1 
ATOM   843  C  CE1 . TYR A 1 151 ? 100.485 125.029 126.966 1.00 48.45  ? 151 TYR A CE1 1 
ATOM   844  C  CE2 . TYR A 1 151 ? 101.500 127.091 126.320 1.00 41.37  ? 151 TYR A CE2 1 
ATOM   845  C  CZ  . TYR A 1 151 ? 100.478 126.404 126.934 1.00 49.46  ? 151 TYR A CZ  1 
ATOM   846  O  OH  . TYR A 1 151 ? 99.445  127.095 127.521 1.00 59.63  ? 151 TYR A OH  1 
ATOM   847  N  N   . TYR A 1 152 ? 104.242 121.904 127.165 1.00 56.38  ? 152 TYR A N   1 
ATOM   848  C  CA  . TYR A 1 152 ? 103.848 121.125 128.336 1.00 45.39  ? 152 TYR A CA  1 
ATOM   849  C  C   . TYR A 1 152 ? 104.946 121.103 129.394 1.00 45.64  ? 152 TYR A C   1 
ATOM   850  O  O   . TYR A 1 152 ? 104.649 121.078 130.593 1.00 36.92  ? 152 TYR A O   1 
ATOM   851  C  CB  . TYR A 1 152 ? 103.472 119.705 127.922 1.00 43.27  ? 152 TYR A CB  1 
ATOM   852  C  CG  . TYR A 1 152 ? 101.984 119.499 127.774 1.00 39.08  ? 152 TYR A CG  1 
ATOM   853  C  CD1 . TYR A 1 152 ? 101.212 119.083 128.848 1.00 42.78  ? 152 TYR A CD1 1 
ATOM   854  C  CD2 . TYR A 1 152 ? 101.350 119.729 126.563 1.00 40.13  ? 152 TYR A CD2 1 
ATOM   855  C  CE1 . TYR A 1 152 ? 99.853  118.896 128.718 1.00 41.56  ? 152 TYR A CE1 1 
ATOM   856  C  CE2 . TYR A 1 152 ? 99.992  119.545 126.425 1.00 45.42  ? 152 TYR A CE2 1 
ATOM   857  C  CZ  . TYR A 1 152 ? 99.249  119.128 127.504 1.00 44.37  ? 152 TYR A CZ  1 
ATOM   858  O  OH  . TYR A 1 152 ? 97.894  118.945 127.369 1.00 55.89  ? 152 TYR A OH  1 
ATOM   859  N  N   . PHE A 1 153 ? 106.211 121.099 128.971 1.00 57.83  ? 153 PHE A N   1 
ATOM   860  C  CA  . PHE A 1 153 ? 107.323 121.141 129.918 1.00 48.95  ? 153 PHE A CA  1 
ATOM   861  C  C   . PHE A 1 153 ? 107.376 122.470 130.664 1.00 50.50  ? 153 PHE A C   1 
ATOM   862  O  O   . PHE A 1 153 ? 107.664 122.502 131.865 1.00 51.44  ? 153 PHE A O   1 
ATOM   863  C  CB  . PHE A 1 153 ? 108.636 120.884 129.179 1.00 41.44  ? 153 PHE A CB  1 
ATOM   864  C  CG  . PHE A 1 153 ? 109.863 121.047 130.030 1.00 49.74  ? 153 PHE A CG  1 
ATOM   865  C  CD1 . PHE A 1 153 ? 110.286 120.027 130.864 1.00 54.29  ? 153 PHE A CD1 1 
ATOM   866  C  CD2 . PHE A 1 153 ? 110.607 122.214 129.981 1.00 52.43  ? 153 PHE A CD2 1 
ATOM   867  C  CE1 . PHE A 1 153 ? 111.420 120.172 131.638 1.00 55.91  ? 153 PHE A CE1 1 
ATOM   868  C  CE2 . PHE A 1 153 ? 111.739 122.365 130.755 1.00 48.23  ? 153 PHE A CE2 1 
ATOM   869  C  CZ  . PHE A 1 153 ? 112.146 121.343 131.586 1.00 50.95  ? 153 PHE A CZ  1 
ATOM   870  N  N   . PHE A 1 154 ? 107.109 123.578 129.968 1.00 55.08  ? 154 PHE A N   1 
ATOM   871  C  CA  . PHE A 1 154 ? 107.207 124.889 130.604 1.00 55.22  ? 154 PHE A CA  1 
ATOM   872  C  C   . PHE A 1 154 ? 106.090 125.121 131.613 1.00 56.28  ? 154 PHE A C   1 
ATOM   873  O  O   . PHE A 1 154 ? 106.248 125.932 132.532 1.00 52.74  ? 154 PHE A O   1 
ATOM   874  C  CB  . PHE A 1 154 ? 107.198 125.994 129.547 1.00 51.26  ? 154 PHE A CB  1 
ATOM   875  C  CG  . PHE A 1 154 ? 108.540 126.244 128.919 1.00 56.64  ? 154 PHE A CG  1 
ATOM   876  C  CD1 . PHE A 1 154 ? 109.681 126.318 129.699 1.00 57.96  ? 154 PHE A CD1 1 
ATOM   877  C  CD2 . PHE A 1 154 ? 108.659 126.407 127.550 1.00 55.03  ? 154 PHE A CD2 1 
ATOM   878  C  CE1 . PHE A 1 154 ? 110.916 126.547 129.124 1.00 57.01  ? 154 PHE A CE1 1 
ATOM   879  C  CE2 . PHE A 1 154 ? 109.891 126.637 126.969 1.00 51.19  ? 154 PHE A CE2 1 
ATOM   880  C  CZ  . PHE A 1 154 ? 111.020 126.707 127.757 1.00 53.73  ? 154 PHE A CZ  1 
ATOM   881  N  N   . SER A 1 155 ? 104.962 124.435 131.462 1.00 55.49  ? 155 SER A N   1 
ATOM   882  C  CA  . SER A 1 155 ? 103.830 124.597 132.364 1.00 50.72  ? 155 SER A CA  1 
ATOM   883  C  C   . SER A 1 155 ? 103.914 123.698 133.591 1.00 59.46  ? 155 SER A C   1 
ATOM   884  O  O   . SER A 1 155 ? 103.026 123.759 134.447 1.00 61.45  ? 155 SER A O   1 
ATOM   885  C  CB  . SER A 1 155 ? 102.521 124.330 131.617 1.00 48.01  ? 155 SER A CB  1 
ATOM   886  O  OG  . SER A 1 155 ? 102.126 122.977 131.750 1.00 62.55  ? 155 SER A OG  1 
ATOM   887  N  N   . SER A 1 156 ? 104.952 122.872 133.698 1.00 59.79  ? 156 SER A N   1 
ATOM   888  C  CA  . SER A 1 156 ? 105.147 121.996 134.844 1.00 51.97  ? 156 SER A CA  1 
ATOM   889  C  C   . SER A 1 156 ? 105.959 122.648 135.954 1.00 56.41  ? 156 SER A C   1 
ATOM   890  O  O   . SER A 1 156 ? 106.143 122.034 137.009 1.00 60.33  ? 156 SER A O   1 
ATOM   891  C  CB  . SER A 1 156 ? 105.834 120.700 134.404 1.00 49.48  ? 156 SER A CB  1 
ATOM   892  O  OG  . SER A 1 156 ? 104.916 119.815 133.791 1.00 54.63  ? 156 SER A OG  1 
ATOM   893  N  N   . MET A 1 157 ? 106.450 123.867 135.743 1.00 71.75  ? 157 MET A N   1 
ATOM   894  C  CA  . MET A 1 157 ? 107.263 124.566 136.737 1.00 70.58  ? 157 MET A CA  1 
ATOM   895  C  C   . MET A 1 157 ? 106.372 125.362 137.692 1.00 73.26  ? 157 MET A C   1 
ATOM   896  O  O   . MET A 1 157 ? 106.332 126.591 137.683 1.00 74.82  ? 157 MET A O   1 
ATOM   897  C  CB  . MET A 1 157 ? 108.279 125.468 136.045 1.00 64.32  ? 157 MET A CB  1 
ATOM   898  C  CG  . MET A 1 157 ? 109.253 124.733 135.145 1.00 69.34  ? 157 MET A CG  1 
ATOM   899  S  SD  . MET A 1 157 ? 110.378 125.853 134.293 1.00 83.82  ? 157 MET A SD  1 
ATOM   900  C  CE  . MET A 1 157 ? 111.442 124.687 133.450 1.00 71.38  ? 157 MET A CE  1 
ATOM   901  N  N   . THR A 1 158 ? 105.645 124.627 138.528 1.00 77.70  ? 158 THR A N   1 
ATOM   902  C  CA  . THR A 1 158 ? 104.720 125.223 139.481 1.00 79.70  ? 158 THR A CA  1 
ATOM   903  C  C   . THR A 1 158 ? 104.595 124.290 140.680 1.00 78.15  ? 158 THR A C   1 
ATOM   904  O  O   . THR A 1 158 ? 105.308 123.288 140.790 1.00 79.46  ? 158 THR A O   1 
ATOM   905  C  CB  . THR A 1 158 ? 103.364 125.499 138.817 1.00 77.87  ? 158 THR A CB  1 
ATOM   906  O  OG1 . THR A 1 158 ? 102.471 126.084 139.772 1.00 83.83  ? 158 THR A OG1 1 
ATOM   907  C  CG2 . THR A 1 158 ? 102.764 124.208 138.288 1.00 69.63  ? 158 THR A CG2 1 
ATOM   908  N  N   . HIS A 1 159 ? 103.679 124.625 141.589 1.00 84.18  ? 159 HIS A N   1 
ATOM   909  C  CA  . HIS A 1 159 ? 103.437 123.805 142.768 1.00 81.79  ? 159 HIS A CA  1 
ATOM   910  C  C   . HIS A 1 159 ? 102.283 122.831 142.580 1.00 84.43  ? 159 HIS A C   1 
ATOM   911  O  O   . HIS A 1 159 ? 102.309 121.736 143.154 1.00 88.02  ? 159 HIS A O   1 
ATOM   912  C  CB  . HIS A 1 159 ? 103.158 124.695 143.982 1.00 83.17  ? 159 HIS A CB  1 
ATOM   913  C  CG  . HIS A 1 159 ? 104.356 125.451 144.465 1.00 90.14  ? 159 HIS A CG  1 
ATOM   914  N  ND1 . HIS A 1 159 ? 105.474 124.826 144.976 1.00 90.60  ? 159 HIS A ND1 1 
ATOM   915  C  CD2 . HIS A 1 159 ? 104.612 126.779 144.516 1.00 90.84  ? 159 HIS A CD2 1 
ATOM   916  C  CE1 . HIS A 1 159 ? 106.366 125.737 145.320 1.00 89.01  ? 159 HIS A CE1 1 
ATOM   917  N  NE2 . HIS A 1 159 ? 105.868 126.930 145.051 1.00 92.23  ? 159 HIS A NE2 1 
ATOM   918  N  N   . VAL A 1 160 ? 101.275 123.203 141.797 1.00 76.33  ? 160 VAL A N   1 
ATOM   919  C  CA  . VAL A 1 160 ? 100.131 122.347 141.507 1.00 73.22  ? 160 VAL A CA  1 
ATOM   920  C  C   . VAL A 1 160 ? 99.940  122.312 139.998 1.00 73.95  ? 160 VAL A C   1 
ATOM   921  O  O   . VAL A 1 160 ? 99.879  123.365 139.354 1.00 81.72  ? 160 VAL A O   1 
ATOM   922  C  CB  . VAL A 1 160 ? 98.852  122.846 142.206 1.00 75.08  ? 160 VAL A CB  1 
ATOM   923  C  CG1 . VAL A 1 160 ? 97.620  122.204 141.593 1.00 72.73  ? 160 VAL A CG1 1 
ATOM   924  C  CG2 . VAL A 1 160 ? 98.919  122.562 143.698 1.00 77.68  ? 160 VAL A CG2 1 
ATOM   925  N  N   . LEU A 1 161 ? 99.845  121.110 139.438 1.00 64.08  ? 161 LEU A N   1 
ATOM   926  C  CA  . LEU A 1 161 ? 99.693  120.976 137.997 1.00 59.53  ? 161 LEU A CA  1 
ATOM   927  C  C   . LEU A 1 161 ? 98.366  121.585 137.547 1.00 61.37  ? 161 LEU A C   1 
ATOM   928  O  O   . LEU A 1 161 ? 97.348  121.430 138.227 1.00 70.06  ? 161 LEU A O   1 
ATOM   929  C  CB  . LEU A 1 161 ? 99.762  119.509 137.581 1.00 55.57  ? 161 LEU A CB  1 
ATOM   930  C  CG  . LEU A 1 161 ? 101.113 118.824 137.772 1.00 60.52  ? 161 LEU A CG  1 
ATOM   931  C  CD1 . LEU A 1 161 ? 100.986 117.332 137.529 1.00 64.12  ? 161 LEU A CD1 1 
ATOM   932  C  CD2 . LEU A 1 161 ? 102.160 119.435 136.859 1.00 62.63  ? 161 LEU A CD2 1 
ATOM   933  N  N   . PRO A 1 162 ? 98.346  122.288 136.411 1.00 57.24  ? 162 PRO A N   1 
ATOM   934  C  CA  . PRO A 1 162 ? 97.108  122.950 135.972 1.00 60.76  ? 162 PRO A CA  1 
ATOM   935  C  C   . PRO A 1 162 ? 96.056  122.001 135.423 1.00 59.86  ? 162 PRO A C   1 
ATOM   936  O  O   . PRO A 1 162 ? 94.923  122.440 135.188 1.00 63.57  ? 162 PRO A O   1 
ATOM   937  C  CB  . PRO A 1 162 ? 97.598  123.917 134.890 1.00 60.61  ? 162 PRO A CB  1 
ATOM   938  C  CG  . PRO A 1 162 ? 98.826  123.273 134.352 1.00 54.19  ? 162 PRO A CG  1 
ATOM   939  C  CD  . PRO A 1 162 ? 99.478  122.579 135.514 1.00 53.72  ? 162 PRO A CD  1 
ATOM   940  N  N   . TRP A 1 163 ? 96.382  120.727 135.209 1.00 55.12  ? 163 TRP A N   1 
ATOM   941  C  CA  . TRP A 1 163 ? 95.442  119.751 134.672 1.00 52.19  ? 163 TRP A CA  1 
ATOM   942  C  C   . TRP A 1 163 ? 95.028  118.723 135.720 1.00 58.26  ? 163 TRP A C   1 
ATOM   943  O  O   . TRP A 1 163 ? 94.583  117.626 135.379 1.00 68.72  ? 163 TRP A O   1 
ATOM   944  C  CB  . TRP A 1 163 ? 96.040  119.052 133.451 1.00 50.98  ? 163 TRP A CB  1 
ATOM   945  C  CG  . TRP A 1 163 ? 97.334  118.355 133.735 1.00 50.01  ? 163 TRP A CG  1 
ATOM   946  C  CD1 . TRP A 1 163 ? 97.494  117.133 134.318 1.00 50.85  ? 163 TRP A CD1 1 
ATOM   947  C  CD2 . TRP A 1 163 ? 98.652  118.838 133.451 1.00 58.24  ? 163 TRP A CD2 1 
ATOM   948  N  NE1 . TRP A 1 163 ? 98.829  116.826 134.417 1.00 54.19  ? 163 TRP A NE1 1 
ATOM   949  C  CE2 . TRP A 1 163 ? 99.561  117.856 133.890 1.00 56.97  ? 163 TRP A CE2 1 
ATOM   950  C  CE3 . TRP A 1 163 ? 99.152  120.006 132.867 1.00 58.15  ? 163 TRP A CE3 1 
ATOM   951  C  CZ2 . TRP A 1 163 ? 100.939 118.005 133.764 1.00 52.78  ? 163 TRP A CZ2 1 
ATOM   952  C  CZ3 . TRP A 1 163 ? 100.520 120.152 132.744 1.00 52.36  ? 163 TRP A CZ3 1 
ATOM   953  C  CH2 . TRP A 1 163 ? 101.397 119.158 133.190 1.00 50.84  ? 163 TRP A CH2 1 
ATOM   954  N  N   . ALA A 1 164 ? 95.169  119.063 137.000 1.00 58.41  ? 164 ALA A N   1 
ATOM   955  C  CA  . ALA A 1 164 ? 94.907  118.121 138.079 1.00 58.10  ? 164 ALA A CA  1 
ATOM   956  C  C   . ALA A 1 164 ? 93.536  118.289 138.718 1.00 66.55  ? 164 ALA A C   1 
ATOM   957  O  O   . ALA A 1 164 ? 93.032  117.338 139.324 1.00 73.27  ? 164 ALA A O   1 
ATOM   958  C  CB  . ALA A 1 164 ? 95.980  118.246 139.165 1.00 61.63  ? 164 ALA A CB  1 
ATOM   959  N  N   . TYR A 1 165 ? 92.922  119.460 138.605 1.00 74.25  ? 165 TYR A N   1 
ATOM   960  C  CA  . TYR A 1 165 ? 91.631  119.731 139.221 1.00 75.56  ? 165 TYR A CA  1 
ATOM   961  C  C   . TYR A 1 165 ? 90.644  120.223 138.167 1.00 77.93  ? 165 TYR A C   1 
ATOM   962  O  O   . TYR A 1 165 ? 90.979  120.380 136.991 1.00 75.80  ? 165 TYR A O   1 
ATOM   963  C  CB  . TYR A 1 165 ? 91.779  120.736 140.367 1.00 74.56  ? 165 TYR A CB  1 
ATOM   964  C  CG  . TYR A 1 165 ? 92.690  120.244 141.468 1.00 77.53  ? 165 TYR A CG  1 
ATOM   965  C  CD1 . TYR A 1 165 ? 92.392  119.087 142.174 1.00 77.03  ? 165 TYR A CD1 1 
ATOM   966  C  CD2 . TYR A 1 165 ? 93.856  120.924 141.788 1.00 78.93  ? 165 TYR A CD2 1 
ATOM   967  C  CE1 . TYR A 1 165 ? 93.222  118.627 143.175 1.00 77.26  ? 165 TYR A CE1 1 
ATOM   968  C  CE2 . TYR A 1 165 ? 94.693  120.470 142.789 1.00 78.81  ? 165 TYR A CE2 1 
ATOM   969  C  CZ  . TYR A 1 165 ? 94.371  119.322 143.479 1.00 79.60  ? 165 TYR A CZ  1 
ATOM   970  O  OH  . TYR A 1 165 ? 95.203  118.868 144.476 1.00 83.96  ? 165 TYR A OH  1 
ATOM   971  N  N   . CYS A 1 166 ? 89.406  120.470 138.607 1.00 84.13  ? 166 CYS A N   1 
ATOM   972  C  CA  . CYS A 1 166 ? 88.297  120.722 137.694 1.00 81.40  ? 166 CYS A CA  1 
ATOM   973  C  C   . CYS A 1 166 ? 87.669  122.095 137.915 1.00 83.96  ? 166 CYS A C   1 
ATOM   974  O  O   . CYS A 1 166 ? 86.567  122.349 137.420 1.00 86.38  ? 166 CYS A O   1 
ATOM   975  C  CB  . CYS A 1 166 ? 87.232  119.632 137.847 1.00 77.14  ? 166 CYS A CB  1 
ATOM   976  S  SG  . CYS A 1 166 ? 87.279  118.310 136.611 1.00 95.15  ? 166 CYS A SG  1 
ATOM   977  N  N   . ASN A 1 167 ? 88.341  122.984 138.644 1.00 82.51  ? 167 ASN A N   1 
ATOM   978  C  CA  . ASN A 1 167 ? 87.784  124.284 138.998 1.00 82.87  ? 167 ASN A CA  1 
ATOM   979  C  C   . ASN A 1 167 ? 88.409  125.441 138.230 1.00 84.81  ? 167 ASN A C   1 
ATOM   980  O  O   . ASN A 1 167 ? 88.200  126.599 138.606 1.00 84.44  ? 167 ASN A O   1 
ATOM   981  C  CB  . ASN A 1 167 ? 87.934  124.527 140.504 1.00 82.53  ? 167 ASN A CB  1 
ATOM   982  C  CG  . ASN A 1 167 ? 89.379  124.480 140.962 1.00 84.23  ? 167 ASN A CG  1 
ATOM   983  O  OD1 . ASN A 1 167 ? 90.264  124.049 140.222 1.00 81.84  ? 167 ASN A OD1 1 
ATOM   984  N  ND2 . ASN A 1 167 ? 89.626  124.926 142.188 1.00 85.44  ? 167 ASN A ND2 1 
ATOM   985  N  N   . ASN A 1 168 ? 89.166  125.163 137.172 1.00 81.95  ? 168 ASN A N   1 
ATOM   986  C  CA  . ASN A 1 168 ? 89.810  126.213 136.403 1.00 75.26  ? 168 ASN A CA  1 
ATOM   987  C  C   . ASN A 1 168 ? 88.781  126.998 135.590 1.00 79.95  ? 168 ASN A C   1 
ATOM   988  O  O   . ASN A 1 168 ? 87.673  126.518 135.345 1.00 83.64  ? 168 ASN A O   1 
ATOM   989  C  CB  . ASN A 1 168 ? 90.873  125.611 135.489 1.00 75.37  ? 168 ASN A CB  1 
ATOM   990  C  CG  . ASN A 1 168 ? 91.793  124.658 136.219 1.00 80.43  ? 168 ASN A CG  1 
ATOM   991  O  OD1 . ASN A 1 168 ? 91.721  123.443 136.037 1.00 82.41  ? 168 ASN A OD1 1 
ATOM   992  N  ND2 . ASN A 1 168 ? 92.666  125.205 137.055 1.00 78.42  ? 168 ASN A ND2 1 
ATOM   993  N  N   . PRO A 1 169 ? 89.121  128.225 135.176 1.00 80.24  ? 169 PRO A N   1 
ATOM   994  C  CA  . PRO A 1 169 ? 88.159  129.040 134.413 1.00 73.57  ? 169 PRO A CA  1 
ATOM   995  C  C   . PRO A 1 169 ? 87.703  128.417 133.102 1.00 76.30  ? 169 PRO A C   1 
ATOM   996  O  O   . PRO A 1 169 ? 86.586  128.713 132.660 1.00 80.40  ? 169 PRO A O   1 
ATOM   997  C  CB  . PRO A 1 169 ? 88.928  130.345 134.163 1.00 72.51  ? 169 PRO A CB  1 
ATOM   998  C  CG  . PRO A 1 169 ? 89.910  130.411 135.278 1.00 77.97  ? 169 PRO A CG  1 
ATOM   999  C  CD  . PRO A 1 169 ? 90.336  128.991 135.507 1.00 81.23  ? 169 PRO A CD  1 
ATOM   1000 N  N   . TRP A 1 170 ? 88.518  127.576 132.466 1.00 70.09  ? 170 TRP A N   1 
ATOM   1001 C  CA  . TRP A 1 170 ? 88.147  126.971 131.194 1.00 70.44  ? 170 TRP A CA  1 
ATOM   1002 C  C   . TRP A 1 170 ? 87.365  125.673 131.349 1.00 74.65  ? 170 TRP A C   1 
ATOM   1003 O  O   . TRP A 1 170 ? 86.910  125.122 130.342 1.00 76.09  ? 170 TRP A O   1 
ATOM   1004 C  CB  . TRP A 1 170 ? 89.397  126.710 130.343 1.00 66.86  ? 170 TRP A CB  1 
ATOM   1005 C  CG  . TRP A 1 170 ? 90.422  125.847 131.010 1.00 71.25  ? 170 TRP A CG  1 
ATOM   1006 C  CD1 . TRP A 1 170 ? 90.516  124.488 130.946 1.00 69.20  ? 170 TRP A CD1 1 
ATOM   1007 C  CD2 . TRP A 1 170 ? 91.506  126.284 131.838 1.00 72.18  ? 170 TRP A CD2 1 
ATOM   1008 N  NE1 . TRP A 1 170 ? 91.587  124.052 131.685 1.00 69.01  ? 170 TRP A NE1 1 
ATOM   1009 C  CE2 . TRP A 1 170 ? 92.212  125.135 132.243 1.00 69.73  ? 170 TRP A CE2 1 
ATOM   1010 C  CE3 . TRP A 1 170 ? 91.947  127.536 132.278 1.00 67.66  ? 170 TRP A CE3 1 
ATOM   1011 C  CZ2 . TRP A 1 170 ? 93.335  125.200 133.064 1.00 67.67  ? 170 TRP A CZ2 1 
ATOM   1012 C  CZ3 . TRP A 1 170 ? 93.061  127.598 133.093 1.00 67.20  ? 170 TRP A CZ3 1 
ATOM   1013 C  CH2 . TRP A 1 170 ? 93.742  126.438 133.478 1.00 66.58  ? 170 TRP A CH2 1 
ATOM   1014 N  N   . ASN A 1 171 ? 87.196  125.177 132.571 1.00 77.67  ? 171 ASN A N   1 
ATOM   1015 C  CA  . ASN A 1 171 ? 86.458  123.943 132.786 1.00 76.07  ? 171 ASN A CA  1 
ATOM   1016 C  C   . ASN A 1 171 ? 84.954  124.186 132.680 1.00 77.91  ? 171 ASN A C   1 
ATOM   1017 O  O   . ASN A 1 171 ? 84.463  125.305 132.849 1.00 78.03  ? 171 ASN A O   1 
ATOM   1018 C  CB  . ASN A 1 171 ? 86.798  123.347 134.151 1.00 73.65  ? 171 ASN A CB  1 
ATOM   1019 C  CG  . ASN A 1 171 ? 88.206  122.794 134.209 1.00 75.31  ? 171 ASN A CG  1 
ATOM   1020 O  OD1 . ASN A 1 171 ? 88.914  122.973 135.197 1.00 79.85  ? 171 ASN A OD1 1 
ATOM   1021 N  ND2 . ASN A 1 171 ? 88.620  122.117 133.145 1.00 74.49  ? 171 ASN A ND2 1 
ATOM   1022 N  N   . THR A 1 172 ? 84.222  123.114 132.397 1.00 88.16  ? 172 THR A N   1 
ATOM   1023 C  CA  . THR A 1 172 ? 82.773  123.148 132.254 1.00 88.97  ? 172 THR A CA  1 
ATOM   1024 C  C   . THR A 1 172 ? 82.129  122.275 133.328 1.00 89.11  ? 172 THR A C   1 
ATOM   1025 O  O   . THR A 1 172 ? 82.801  121.735 134.209 1.00 91.21  ? 172 THR A O   1 
ATOM   1026 C  CB  . THR A 1 172 ? 82.346  122.686 130.856 1.00 85.58  ? 172 THR A CB  1 
ATOM   1027 O  OG1 . THR A 1 172 ? 82.464  121.262 130.765 1.00 83.85  ? 172 THR A OG1 1 
ATOM   1028 C  CG2 . THR A 1 172 ? 83.219  123.331 129.792 1.00 86.90  ? 172 THR A CG2 1 
ATOM   1029 N  N   . HIS A 1 173 ? 80.805  122.139 133.244 1.00 96.02  ? 173 HIS A N   1 
ATOM   1030 C  CA  . HIS A 1 173 ? 80.057  121.360 134.223 1.00 97.39  ? 173 HIS A CA  1 
ATOM   1031 C  C   . HIS A 1 173 ? 80.162  119.858 133.995 1.00 101.99 ? 173 HIS A C   1 
ATOM   1032 O  O   . HIS A 1 173 ? 79.761  119.087 134.874 1.00 105.95 ? 173 HIS A O   1 
ATOM   1033 C  CB  . HIS A 1 173 ? 78.584  121.779 134.219 1.00 97.19  ? 173 HIS A CB  1 
ATOM   1034 C  CG  . HIS A 1 173 ? 77.901  121.589 132.901 1.00 104.20 ? 173 HIS A CG  1 
ATOM   1035 N  ND1 . HIS A 1 173 ? 78.142  122.401 131.814 1.00 106.94 ? 173 HIS A ND1 1 
ATOM   1036 C  CD2 . HIS A 1 173 ? 76.978  120.684 132.497 1.00 102.17 ? 173 HIS A CD2 1 
ATOM   1037 C  CE1 . HIS A 1 173 ? 77.401  122.002 130.795 1.00 103.68 ? 173 HIS A CE1 1 
ATOM   1038 N  NE2 . HIS A 1 173 ? 76.686  120.961 131.183 1.00 102.41 ? 173 HIS A NE2 1 
ATOM   1039 N  N   . ASP A 1 174 ? 80.683  119.423 132.848 1.00 97.47  ? 174 ASP A N   1 
ATOM   1040 C  CA  . ASP A 1 174 ? 80.915  118.006 132.604 1.00 96.63  ? 174 ASP A CA  1 
ATOM   1041 C  C   . ASP A 1 174 ? 82.237  117.520 133.183 1.00 96.76  ? 174 ASP A C   1 
ATOM   1042 O  O   . ASP A 1 174 ? 82.542  116.328 133.073 1.00 93.98  ? 174 ASP A O   1 
ATOM   1043 C  CB  . ASP A 1 174 ? 80.877  117.718 131.102 1.00 96.59  ? 174 ASP A CB  1 
ATOM   1044 C  CG  . ASP A 1 174 ? 79.638  118.277 130.431 1.00 98.55  ? 174 ASP A CG  1 
ATOM   1045 O  OD1 . ASP A 1 174 ? 78.607  118.435 131.118 1.00 96.69  ? 174 ASP A OD1 1 
ATOM   1046 O  OD2 . ASP A 1 174 ? 79.694  118.557 129.215 1.00 98.72  ? 174 ASP A OD2 1 
ATOM   1047 N  N   . CYS A 1 175 ? 83.023  118.412 133.781 1.00 94.56  ? 175 CYS A N   1 
ATOM   1048 C  CA  . CYS A 1 175 ? 84.316  118.040 134.338 1.00 91.81  ? 175 CYS A CA  1 
ATOM   1049 C  C   . CYS A 1 175 ? 84.143  117.039 135.474 1.00 91.39  ? 175 CYS A C   1 
ATOM   1050 O  O   . CYS A 1 175 ? 83.278  117.203 136.338 1.00 92.71  ? 175 CYS A O   1 
ATOM   1051 C  CB  . CYS A 1 175 ? 85.040  119.292 134.834 1.00 92.38  ? 175 CYS A CB  1 
ATOM   1052 S  SG  . CYS A 1 175 ? 86.840  119.197 134.838 1.00 100.40 ? 175 CYS A SG  1 
ATOM   1053 N  N   . ALA A 1 176 ? 84.973  115.998 135.470 1.00 89.07  ? 176 ALA A N   1 
ATOM   1054 C  CA  . ALA A 1 176 ? 84.938  114.964 136.499 1.00 86.84  ? 176 ALA A CA  1 
ATOM   1055 C  C   . ALA A 1 176 ? 86.357  114.482 136.751 1.00 89.71  ? 176 ALA A C   1 
ATOM   1056 O  O   . ALA A 1 176 ? 86.980  113.900 135.859 1.00 90.38  ? 176 ALA A O   1 
ATOM   1057 C  CB  . ALA A 1 176 ? 84.038  113.796 136.088 1.00 89.37  ? 176 ALA A CB  1 
ATOM   1058 N  N   . GLY A 1 177 ? 86.856  114.588 137.966 1.00 93.63  ? 177 GLY A N   1 
ATOM   1059 C  CA  . GLY A 1 177 ? 88.236  114.201 138.234 1.00 93.15  ? 177 GLY A CA  1 
ATOM   1060 C  C   . GLY A 1 177 ? 88.508  113.385 139.474 1.00 96.51  ? 177 GLY A C   1 
ATOM   1061 O  O   . GLY A 1 177 ? 87.793  113.524 140.446 1.00 98.38  ? 177 GLY A O   1 
ATOM   1062 N  N   . VAL A 1 178 ? 89.540  112.551 139.461 1.00 103.28 ? 178 VAL A N   1 
ATOM   1063 C  CA  . VAL A 1 178 ? 89.851  111.655 140.593 1.00 102.82 ? 178 VAL A CA  1 
ATOM   1064 C  C   . VAL A 1 178 ? 90.568  112.295 141.755 1.00 103.02 ? 178 VAL A C   1 
ATOM   1065 O  O   . VAL A 1 178 ? 90.800  111.626 142.747 1.00 102.39 ? 178 VAL A O   1 
ATOM   1066 C  CB  . VAL A 1 178 ? 90.760  110.503 140.179 1.00 30.00  ? 178 VAL A CB  1 
ATOM   1067 C  CG1 . VAL A 1 178 ? 89.978  109.487 139.373 1.00 30.00  ? 178 VAL A CG1 1 
ATOM   1068 C  CG2 . VAL A 1 178 ? 91.942  111.023 139.386 1.00 30.00  ? 178 VAL A CG2 1 
ATOM   1069 N  N   . LEU A 1 179 ? 90.950  113.561 141.630 1.00 111.32 ? 179 LEU A N   1 
ATOM   1070 C  CA  . LEU A 1 179 ? 91.667  114.277 142.676 1.00 110.66 ? 179 LEU A CA  1 
ATOM   1071 C  C   . LEU A 1 179 ? 93.114  113.815 142.834 1.00 110.86 ? 179 LEU A C   1 
ATOM   1072 O  O   . LEU A 1 179 ? 94.013  114.311 142.159 1.00 109.95 ? 179 LEU A O   1 
ATOM   1073 C  CB  . LEU A 1 179 ? 90.897  114.165 143.982 1.00 30.00  ? 179 LEU A CB  1 
ATOM   1074 C  CG  . LEU A 1 179 ? 89.771  115.183 144.157 1.00 30.00  ? 179 LEU A CG  1 
ATOM   1075 C  CD1 . LEU A 1 179 ? 88.499  114.703 143.482 1.00 30.00  ? 179 LEU A CD1 1 
ATOM   1076 C  CD2 . LEU A 1 179 ? 89.524  115.469 145.630 1.00 30.00  ? 179 LEU A CD2 1 
ATOM   1077 N  N   . ARG A 1 207 ? 80.711  111.907 130.955 1.00 94.98  ? 207 ARG A N   1 
ATOM   1078 C  CA  . ARG A 1 207 ? 81.648  112.702 131.739 1.00 93.65  ? 207 ARG A CA  1 
ATOM   1079 C  C   . ARG A 1 207 ? 82.888  113.044 130.925 1.00 94.98  ? 207 ARG A C   1 
ATOM   1080 O  O   . ARG A 1 207 ? 83.046  112.583 129.795 1.00 95.46  ? 207 ARG A O   1 
ATOM   1081 C  CB  . ARG A 1 207 ? 82.042  111.962 133.018 1.00 95.06  ? 207 ARG A CB  1 
ATOM   1082 C  CG  . ARG A 1 207 ? 80.889  111.723 133.980 1.00 94.46  ? 207 ARG A CG  1 
ATOM   1083 C  CD  . ARG A 1 207 ? 79.968  112.931 134.051 1.00 96.49  ? 207 ARG A CD  1 
ATOM   1084 N  NE  . ARG A 1 207 ? 80.271  113.783 135.194 1.00 100.48 ? 207 ARG A NE  1 
ATOM   1085 C  CZ  . ARG A 1 207 ? 79.431  114.668 135.712 1.00 99.20  ? 207 ARG A CZ  1 
ATOM   1086 N  NH1 . ARG A 1 207 ? 78.221  114.850 135.208 1.00 98.65  ? 207 ARG A NH1 1 
ATOM   1087 N  NH2 . ARG A 1 207 ? 79.814  115.390 136.761 1.00 95.02  ? 207 ARG A NH2 1 
ATOM   1088 N  N   . THR A 1 208 ? 83.767  113.854 131.507 1.00 89.41  ? 208 THR A N   1 
ATOM   1089 C  CA  . THR A 1 208 ? 84.970  114.325 130.838 1.00 85.85  ? 208 THR A CA  1 
ATOM   1090 C  C   . THR A 1 208 ? 86.136  114.305 131.817 1.00 84.90  ? 208 THR A C   1 
ATOM   1091 O  O   . THR A 1 208 ? 85.954  114.307 133.038 1.00 86.17  ? 208 THR A O   1 
ATOM   1092 C  CB  . THR A 1 208 ? 84.775  115.737 130.270 1.00 86.57  ? 208 THR A CB  1 
ATOM   1093 O  OG1 . THR A 1 208 ? 83.717  115.724 129.305 1.00 88.64  ? 208 THR A OG1 1 
ATOM   1094 C  CG2 . THR A 1 208 ? 86.042  116.214 129.596 1.00 85.97  ? 208 THR A CG2 1 
ATOM   1095 N  N   . SER A 1 209 ? 87.350  114.283 131.266 1.00 72.54  ? 209 SER A N   1 
ATOM   1096 C  CA  . SER A 1 209 ? 88.560  114.273 132.070 1.00 73.21  ? 209 SER A CA  1 
ATOM   1097 C  C   . SER A 1 209 ? 89.186  115.662 132.116 1.00 77.83  ? 209 SER A C   1 
ATOM   1098 O  O   . SER A 1 209 ? 89.151  116.388 131.117 1.00 79.87  ? 209 SER A O   1 
ATOM   1099 C  CB  . SER A 1 209 ? 89.583  113.278 131.512 1.00 72.83  ? 209 SER A CB  1 
ATOM   1100 O  OG  . SER A 1 209 ? 90.392  112.746 132.545 1.00 73.18  ? 209 SER A OG  1 
ATOM   1101 N  N   . PRO A 1 210 ? 89.749  116.063 133.260 1.00 67.07  ? 210 PRO A N   1 
ATOM   1102 C  CA  . PRO A 1 210 ? 90.407  117.380 133.321 1.00 60.96  ? 210 PRO A CA  1 
ATOM   1103 C  C   . PRO A 1 210 ? 91.570  117.514 132.355 1.00 63.73  ? 210 PRO A C   1 
ATOM   1104 O  O   . PRO A 1 210 ? 91.796  118.601 131.808 1.00 68.79  ? 210 PRO A O   1 
ATOM   1105 C  CB  . PRO A 1 210 ? 90.868  117.474 134.783 1.00 60.55  ? 210 PRO A CB  1 
ATOM   1106 C  CG  . PRO A 1 210 ? 90.072  116.451 135.518 1.00 61.54  ? 210 PRO A CG  1 
ATOM   1107 C  CD  . PRO A 1 210 ? 89.806  115.352 134.547 1.00 65.59  ? 210 PRO A CD  1 
ATOM   1108 N  N   . SER A 1 211 ? 92.318  116.432 132.131 1.00 59.55  ? 211 SER A N   1 
ATOM   1109 C  CA  . SER A 1 211 ? 93.465  116.493 131.232 1.00 55.33  ? 211 SER A CA  1 
ATOM   1110 C  C   . SER A 1 211 ? 93.032  116.774 129.799 1.00 57.84  ? 211 SER A C   1 
ATOM   1111 O  O   . SER A 1 211 ? 93.652  117.587 129.102 1.00 62.36  ? 211 SER A O   1 
ATOM   1112 C  CB  . SER A 1 211 ? 94.257  115.189 131.307 1.00 55.86  ? 211 SER A CB  1 
ATOM   1113 O  OG  . SER A 1 211 ? 95.595  115.381 130.891 1.00 69.28  ? 211 SER A OG  1 
ATOM   1114 N  N   . GLU A 1 212 ? 91.964  116.121 129.341 1.00 60.33  ? 212 GLU A N   1 
ATOM   1115 C  CA  . GLU A 1 212 ? 91.500  116.346 127.978 1.00 62.11  ? 212 GLU A CA  1 
ATOM   1116 C  C   . GLU A 1 212 ? 90.876  117.726 127.814 1.00 56.38  ? 212 GLU A C   1 
ATOM   1117 O  O   . GLU A 1 212 ? 91.020  118.343 126.754 1.00 58.75  ? 212 GLU A O   1 
ATOM   1118 C  CB  . GLU A 1 212 ? 90.508  115.257 127.569 1.00 60.93  ? 212 GLU A CB  1 
ATOM   1119 C  CG  . GLU A 1 212 ? 90.073  115.334 126.117 1.00 65.84  ? 212 GLU A CG  1 
ATOM   1120 C  CD  . GLU A 1 212 ? 88.659  115.839 125.957 1.00 71.51  ? 212 GLU A CD  1 
ATOM   1121 O  OE1 . GLU A 1 212 ? 88.356  116.447 124.909 1.00 71.74  ? 212 GLU A OE1 1 
ATOM   1122 O  OE2 . GLU A 1 212 ? 87.849  115.624 126.880 1.00 70.29  ? 212 GLU A OE2 1 
ATOM   1123 N  N   . GLU A 1 213 ? 90.191  118.228 128.845 1.00 60.31  ? 213 GLU A N   1 
ATOM   1124 C  CA  . GLU A 1 213 ? 89.686  119.596 128.795 1.00 61.10  ? 213 GLU A CA  1 
ATOM   1125 C  C   . GLU A 1 213 ? 90.828  120.601 128.728 1.00 59.40  ? 213 GLU A C   1 
ATOM   1126 O  O   . GLU A 1 213 ? 90.748  121.594 127.997 1.00 61.42  ? 213 GLU A O   1 
ATOM   1127 C  CB  . GLU A 1 213 ? 88.795  119.874 130.005 1.00 61.33  ? 213 GLU A CB  1 
ATOM   1128 C  CG  . GLU A 1 213 ? 87.436  119.204 129.937 1.00 67.64  ? 213 GLU A CG  1 
ATOM   1129 C  CD  . GLU A 1 213 ? 86.350  120.025 130.603 1.00 74.72  ? 213 GLU A CD  1 
ATOM   1130 O  OE1 . GLU A 1 213 ? 86.650  120.702 131.608 1.00 76.84  ? 213 GLU A OE1 1 
ATOM   1131 O  OE2 . GLU A 1 213 ? 85.199  119.995 130.123 1.00 74.28  ? 213 GLU A OE2 1 
ATOM   1132 N  N   . TYR A 1 214 ? 91.900  120.363 129.487 1.00 53.28  ? 214 TYR A N   1 
ATOM   1133 C  CA  . TYR A 1 214 ? 93.077  121.221 129.396 1.00 48.59  ? 214 TYR A CA  1 
ATOM   1134 C  C   . TYR A 1 214 ? 93.694  121.162 128.004 1.00 53.47  ? 214 TYR A C   1 
ATOM   1135 O  O   . TYR A 1 214 ? 94.110  122.189 127.456 1.00 59.63  ? 214 TYR A O   1 
ATOM   1136 C  CB  . TYR A 1 214 ? 94.100  120.812 130.456 1.00 48.69  ? 214 TYR A CB  1 
ATOM   1137 C  CG  . TYR A 1 214 ? 95.292  121.734 130.564 1.00 55.24  ? 214 TYR A CG  1 
ATOM   1138 C  CD1 . TYR A 1 214 ? 95.183  122.969 131.184 1.00 53.87  ? 214 TYR A CD1 1 
ATOM   1139 C  CD2 . TYR A 1 214 ? 96.527  121.366 130.050 1.00 48.94  ? 214 TYR A CD2 1 
ATOM   1140 C  CE1 . TYR A 1 214 ? 96.269  123.813 131.287 1.00 50.75  ? 214 TYR A CE1 1 
ATOM   1141 C  CE2 . TYR A 1 214 ? 97.618  122.204 130.149 1.00 47.43  ? 214 TYR A CE2 1 
ATOM   1142 C  CZ  . TYR A 1 214 ? 97.483  123.426 130.768 1.00 50.15  ? 214 TYR A CZ  1 
ATOM   1143 O  OH  . TYR A 1 214 ? 98.565  124.266 130.870 1.00 58.74  ? 214 TYR A OH  1 
ATOM   1144 N  N   . TRP A 1 215 ? 93.767  119.965 127.422 1.00 52.76  ? 215 TRP A N   1 
ATOM   1145 C  CA  . TRP A 1 215 ? 94.356  119.810 126.095 1.00 44.60  ? 215 TRP A CA  1 
ATOM   1146 C  C   . TRP A 1 215 ? 93.526  120.510 125.024 1.00 50.32  ? 215 TRP A C   1 
ATOM   1147 O  O   . TRP A 1 215 ? 94.078  121.136 124.112 1.00 52.65  ? 215 TRP A O   1 
ATOM   1148 C  CB  . TRP A 1 215 ? 94.514  118.323 125.777 1.00 50.30  ? 215 TRP A CB  1 
ATOM   1149 C  CG  . TRP A 1 215 ? 94.689  117.995 124.322 1.00 50.09  ? 215 TRP A CG  1 
ATOM   1150 C  CD1 . TRP A 1 215 ? 93.747  117.481 123.481 1.00 44.61  ? 215 TRP A CD1 1 
ATOM   1151 C  CD2 . TRP A 1 215 ? 95.886  118.131 123.546 1.00 50.96  ? 215 TRP A CD2 1 
ATOM   1152 N  NE1 . TRP A 1 215 ? 94.277  117.300 122.229 1.00 43.33  ? 215 TRP A NE1 1 
ATOM   1153 C  CE2 . TRP A 1 215 ? 95.590  117.690 122.243 1.00 49.18  ? 215 TRP A CE2 1 
ATOM   1154 C  CE3 . TRP A 1 215 ? 97.176  118.588 123.826 1.00 47.53  ? 215 TRP A CE3 1 
ATOM   1155 C  CZ2 . TRP A 1 215 ? 96.536  117.693 121.221 1.00 43.02  ? 215 TRP A CZ2 1 
ATOM   1156 C  CZ3 . TRP A 1 215 ? 98.113  118.590 122.811 1.00 50.52  ? 215 TRP A CZ3 1 
ATOM   1157 C  CH2 . TRP A 1 215 ? 97.788  118.146 121.525 1.00 42.67  ? 215 TRP A CH2 1 
ATOM   1158 N  N   . ARG A 1 216 ? 92.199  120.418 125.116 1.00 61.59  ? 216 ARG A N   1 
ATOM   1159 C  CA  . ARG A 1 216 ? 91.343  120.906 124.039 1.00 55.08  ? 216 ARG A CA  1 
ATOM   1160 C  C   . ARG A 1 216 ? 91.014  122.386 124.192 1.00 52.70  ? 216 ARG A C   1 
ATOM   1161 O  O   . ARG A 1 216 ? 91.155  123.160 123.240 1.00 58.07  ? 216 ARG A O   1 
ATOM   1162 C  CB  . ARG A 1 216 ? 90.056  120.083 123.983 1.00 50.71  ? 216 ARG A CB  1 
ATOM   1163 C  CG  . ARG A 1 216 ? 89.113  120.481 122.861 1.00 58.10  ? 216 ARG A CG  1 
ATOM   1164 C  CD  . ARG A 1 216 ? 87.831  119.663 122.884 1.00 63.02  ? 216 ARG A CD  1 
ATOM   1165 N  NE  . ARG A 1 216 ? 87.034  119.912 124.079 1.00 68.33  ? 216 ARG A NE  1 
ATOM   1166 C  CZ  . ARG A 1 216 ? 86.072  119.112 124.519 1.00 62.44  ? 216 ARG A CZ  1 
ATOM   1167 N  NH1 . ARG A 1 216 ? 85.759  117.995 123.884 1.00 56.03  ? 216 ARG A NH1 1 
ATOM   1168 N  NH2 . ARG A 1 216 ? 85.408  119.440 125.622 1.00 57.71  ? 216 ARG A NH2 1 
ATOM   1169 N  N   . LEU A 1 217 ? 90.564  122.798 125.376 1.00 55.13  ? 217 LEU A N   1 
ATOM   1170 C  CA  . LEU A 1 217 ? 90.020  124.134 125.573 1.00 54.46  ? 217 LEU A CA  1 
ATOM   1171 C  C   . LEU A 1 217 ? 91.061  125.172 125.973 1.00 60.55  ? 217 LEU A C   1 
ATOM   1172 O  O   . LEU A 1 217 ? 90.756  126.368 125.937 1.00 69.17  ? 217 LEU A O   1 
ATOM   1173 C  CB  . LEU A 1 217 ? 88.916  124.098 126.636 1.00 56.53  ? 217 LEU A CB  1 
ATOM   1174 C  CG  . LEU A 1 217 ? 87.675  123.270 126.303 1.00 55.07  ? 217 LEU A CG  1 
ATOM   1175 C  CD1 . LEU A 1 217 ? 86.860  123.010 127.555 1.00 57.17  ? 217 LEU A CD1 1 
ATOM   1176 C  CD2 . LEU A 1 217 ? 86.833  123.967 125.251 1.00 58.92  ? 217 LEU A CD2 1 
ATOM   1177 N  N   . TYR A 1 218 ? 92.261  124.762 126.351 1.00 52.32  ? 218 TYR A N   1 
ATOM   1178 C  CA  . TYR A 1 218 ? 93.243  125.751 126.785 1.00 50.56  ? 218 TYR A CA  1 
ATOM   1179 C  C   . TYR A 1 218 ? 94.524  125.737 125.967 1.00 50.78  ? 218 TYR A C   1 
ATOM   1180 O  O   . TYR A 1 218 ? 95.009  126.803 125.583 1.00 54.04  ? 218 TYR A O   1 
ATOM   1181 C  CB  . TYR A 1 218 ? 93.577  125.536 128.268 1.00 54.55  ? 218 TYR A CB  1 
ATOM   1182 C  CG  . TYR A 1 218 ? 94.301  126.700 128.903 1.00 60.01  ? 218 TYR A CG  1 
ATOM   1183 C  CD1 . TYR A 1 218 ? 93.630  127.874 129.213 1.00 58.75  ? 218 TYR A CD1 1 
ATOM   1184 C  CD2 . TYR A 1 218 ? 95.657  126.626 129.190 1.00 55.88  ? 218 TYR A CD2 1 
ATOM   1185 C  CE1 . TYR A 1 218 ? 94.287  128.940 129.792 1.00 59.95  ? 218 TYR A CE1 1 
ATOM   1186 C  CE2 . TYR A 1 218 ? 96.322  127.687 129.768 1.00 54.72  ? 218 TYR A CE2 1 
ATOM   1187 C  CZ  . TYR A 1 218 ? 95.632  128.841 130.067 1.00 62.40  ? 218 TYR A CZ  1 
ATOM   1188 O  OH  . TYR A 1 218 ? 96.290  129.902 130.644 1.00 64.49  ? 218 TYR A OH  1 
ATOM   1189 N  N   . VAL A 1 219 ? 95.086  124.561 125.691 1.00 49.20  ? 219 VAL A N   1 
ATOM   1190 C  CA  . VAL A 1 219 ? 96.346  124.502 124.958 1.00 45.05  ? 219 VAL A CA  1 
ATOM   1191 C  C   . VAL A 1 219 ? 96.134  124.810 123.482 1.00 55.80  ? 219 VAL A C   1 
ATOM   1192 O  O   . VAL A 1 219 ? 96.885  125.590 122.887 1.00 63.08  ? 219 VAL A O   1 
ATOM   1193 C  CB  . VAL A 1 219 ? 97.014  123.131 125.162 1.00 44.56  ? 219 VAL A CB  1 
ATOM   1194 C  CG1 . VAL A 1 219 ? 98.218  122.987 124.249 1.00 44.68  ? 219 VAL A CG1 1 
ATOM   1195 C  CG2 . VAL A 1 219 ? 97.424  122.957 126.611 1.00 43.67  ? 219 VAL A CG2 1 
ATOM   1196 N  N   . LEU A 1 220 ? 95.113  124.216 122.870 1.00 54.90  ? 220 LEU A N   1 
ATOM   1197 C  CA  . LEU A 1 220 ? 94.860  124.366 121.442 1.00 44.51  ? 220 LEU A CA  1 
ATOM   1198 C  C   . LEU A 1 220 ? 93.778  125.378 121.111 1.00 46.39  ? 220 LEU A C   1 
ATOM   1199 O  O   . LEU A 1 220 ? 93.894  126.079 120.103 1.00 55.57  ? 220 LEU A O   1 
ATOM   1200 C  CB  . LEU A 1 220 ? 94.471  123.017 120.826 1.00 46.48  ? 220 LEU A CB  1 
ATOM   1201 C  CG  . LEU A 1 220 ? 95.439  121.841 120.937 1.00 44.99  ? 220 LEU A CG  1 
ATOM   1202 C  CD1 . LEU A 1 220 ? 94.861  120.642 120.215 1.00 42.19  ? 220 LEU A CD1 1 
ATOM   1203 C  CD2 . LEU A 1 220 ? 96.801  122.200 120.376 1.00 41.94  ? 220 LEU A CD2 1 
ATOM   1204 N  N   . LYS A 1 221 ? 92.734  125.480 121.934 1.00 48.37  ? 221 LYS A N   1 
ATOM   1205 C  CA  . LYS A 1 221 ? 91.530  126.236 121.591 1.00 48.48  ? 221 LYS A CA  1 
ATOM   1206 C  C   . LYS A 1 221 ? 91.013  125.805 120.220 1.00 51.70  ? 221 LYS A C   1 
ATOM   1207 O  O   . LYS A 1 221 ? 90.886  126.604 119.291 1.00 58.35  ? 221 LYS A O   1 
ATOM   1208 C  CB  . LYS A 1 221 ? 91.782  127.744 121.643 1.00 51.21  ? 221 LYS A CB  1 
ATOM   1209 C  CG  . LYS A 1 221 ? 92.663  128.186 122.796 1.00 53.76  ? 221 LYS A CG  1 
ATOM   1210 C  CD  . LYS A 1 221 ? 92.480  129.663 123.093 1.00 59.72  ? 221 LYS A CD  1 
ATOM   1211 C  CE  . LYS A 1 221 ? 93.014  130.018 124.470 1.00 61.51  ? 221 LYS A CE  1 
ATOM   1212 N  NZ  . LYS A 1 221 ? 92.304  131.188 125.053 1.00 62.75  ? 221 LYS A NZ  1 
ATOM   1213 N  N   . LEU A 1 222 ? 90.718  124.511 120.111 1.00 56.38  ? 222 LEU A N   1 
ATOM   1214 C  CA  . LEU A 1 222 ? 90.453  123.882 118.825 1.00 50.75  ? 222 LEU A CA  1 
ATOM   1215 C  C   . LEU A 1 222 ? 89.218  124.476 118.160 1.00 54.57  ? 222 LEU A C   1 
ATOM   1216 O  O   . LEU A 1 222 ? 88.231  124.816 118.817 1.00 60.53  ? 222 LEU A O   1 
ATOM   1217 C  CB  . LEU A 1 222 ? 90.277  122.375 119.016 1.00 51.19  ? 222 LEU A CB  1 
ATOM   1218 C  CG  . LEU A 1 222 ? 90.243  121.513 117.757 1.00 55.94  ? 222 LEU A CG  1 
ATOM   1219 C  CD1 . LEU A 1 222 ? 91.489  121.751 116.930 1.00 56.94  ? 222 LEU A CD1 1 
ATOM   1220 C  CD2 . LEU A 1 222 ? 90.113  120.049 118.128 1.00 51.09  ? 222 LEU A CD2 1 
ATOM   1221 N  N   . SER A 1 223 ? 89.284  124.597 116.837 1.00 57.36  ? 223 SER A N   1 
ATOM   1222 C  CA  . SER A 1 223 ? 88.181  125.076 116.025 1.00 57.81  ? 223 SER A CA  1 
ATOM   1223 C  C   . SER A 1 223 ? 87.240  123.916 115.708 1.00 64.59  ? 223 SER A C   1 
ATOM   1224 O  O   . SER A 1 223 ? 87.419  122.791 116.183 1.00 72.30  ? 223 SER A O   1 
ATOM   1225 C  CB  . SER A 1 223 ? 88.713  125.738 114.753 1.00 51.32  ? 223 SER A CB  1 
ATOM   1226 O  OG  . SER A 1 223 ? 89.454  126.905 115.059 1.00 66.14  ? 223 SER A OG  1 
ATOM   1227 N  N   . ASP A 1 224 ? 86.222  124.186 114.890 1.00 69.85  ? 224 ASP A N   1 
ATOM   1228 C  CA  . ASP A 1 224 ? 85.237  123.175 114.534 1.00 65.86  ? 224 ASP A CA  1 
ATOM   1229 C  C   . ASP A 1 224 ? 85.440  122.594 113.142 1.00 69.65  ? 224 ASP A C   1 
ATOM   1230 O  O   . ASP A 1 224 ? 84.834  121.566 112.825 1.00 74.55  ? 224 ASP A O   1 
ATOM   1231 C  CB  . ASP A 1 224 ? 83.823  123.760 114.630 1.00 68.69  ? 224 ASP A CB  1 
ATOM   1232 C  CG  . ASP A 1 224 ? 83.728  125.152 114.038 1.00 75.33  ? 224 ASP A CG  1 
ATOM   1233 O  OD1 . ASP A 1 224 ? 84.639  125.968 114.290 1.00 67.46  ? 224 ASP A OD1 1 
ATOM   1234 O  OD2 . ASP A 1 224 ? 82.743  125.430 113.323 1.00 76.19  ? 224 ASP A OD2 1 
ATOM   1235 N  N   . ASP A 1 225 ? 86.274  123.218 112.314 1.00 66.04  ? 225 ASP A N   1 
ATOM   1236 C  CA  . ASP A 1 225 ? 86.502  122.766 110.951 1.00 61.42  ? 225 ASP A CA  1 
ATOM   1237 C  C   . ASP A 1 225 ? 87.958  123.016 110.582 1.00 62.95  ? 225 ASP A C   1 
ATOM   1238 O  O   . ASP A 1 225 ? 88.634  123.865 111.168 1.00 70.99  ? 225 ASP A O   1 
ATOM   1239 C  CB  . ASP A 1 225 ? 85.562  123.473 109.965 1.00 66.15  ? 225 ASP A CB  1 
ATOM   1240 C  CG  . ASP A 1 225 ? 85.615  122.874 108.573 1.00 72.52  ? 225 ASP A CG  1 
ATOM   1241 O  OD1 . ASP A 1 225 ? 85.105  121.750 108.388 1.00 74.50  ? 225 ASP A OD1 1 
ATOM   1242 O  OD2 . ASP A 1 225 ? 86.167  123.528 107.665 1.00 70.06  ? 225 ASP A OD2 1 
ATOM   1243 N  N   . ILE A 1 226 ? 88.442  122.254 109.601 1.00 55.09  ? 226 ILE A N   1 
ATOM   1244 C  CA  . ILE A 1 226 ? 89.797  122.462 109.105 1.00 49.77  ? 226 ILE A CA  1 
ATOM   1245 C  C   . ILE A 1 226 ? 89.914  123.804 108.388 1.00 54.11  ? 226 ILE A C   1 
ATOM   1246 O  O   . ILE A 1 226 ? 90.989  124.415 108.378 1.00 59.47  ? 226 ILE A O   1 
ATOM   1247 C  CB  . ILE A 1 226 ? 90.217  121.288 108.200 1.00 49.63  ? 226 ILE A CB  1 
ATOM   1248 C  CG1 . ILE A 1 226 ? 91.673  121.435 107.756 1.00 54.73  ? 226 ILE A CG1 1 
ATOM   1249 C  CG2 . ILE A 1 226 ? 89.292  121.171 106.998 1.00 51.32  ? 226 ILE A CG2 1 
ATOM   1250 C  CD1 . ILE A 1 226 ? 92.295  120.148 107.268 1.00 56.38  ? 226 ILE A CD1 1 
ATOM   1251 N  N   . GLY A 1 227 ? 88.827  124.291 107.795 1.00 48.04  ? 227 GLY A N   1 
ATOM   1252 C  CA  . GLY A 1 227 ? 88.831  125.553 107.086 1.00 44.86  ? 227 GLY A CA  1 
ATOM   1253 C  C   . GLY A 1 227 ? 88.637  126.786 107.935 1.00 57.88  ? 227 GLY A C   1 
ATOM   1254 O  O   . GLY A 1 227 ? 88.618  127.896 107.398 1.00 66.99  ? 227 GLY A O   1 
ATOM   1255 N  N   . ASN A 1 228 ? 88.488  126.630 109.249 1.00 62.84  ? 228 ASN A N   1 
ATOM   1256 C  CA  . ASN A 1 228 ? 88.336  127.757 110.169 1.00 57.70  ? 228 ASN A CA  1 
ATOM   1257 C  C   . ASN A 1 228 ? 89.698  128.013 110.805 1.00 55.76  ? 228 ASN A C   1 
ATOM   1258 O  O   . ASN A 1 228 ? 90.046  127.430 111.831 1.00 55.57  ? 228 ASN A O   1 
ATOM   1259 C  CB  . ASN A 1 228 ? 87.265  127.467 111.213 1.00 59.24  ? 228 ASN A CB  1 
ATOM   1260 C  CG  . ASN A 1 228 ? 86.709  128.727 111.842 1.00 65.03  ? 228 ASN A CG  1 
ATOM   1261 O  OD1 . ASN A 1 228 ? 87.118  129.837 111.504 1.00 65.39  ? 228 ASN A OD1 1 
ATOM   1262 N  ND2 . ASN A 1 228 ? 85.767  128.562 112.762 1.00 66.25  ? 228 ASN A ND2 1 
ATOM   1263 N  N   . PHE A 1 229 ? 90.475  128.902 110.179 1.00 59.08  ? 229 PHE A N   1 
ATOM   1264 C  CA  . PHE A 1 229 ? 91.840  129.152 110.631 1.00 55.01  ? 229 PHE A CA  1 
ATOM   1265 C  C   . PHE A 1 229 ? 91.871  129.752 112.032 1.00 62.60  ? 229 PHE A C   1 
ATOM   1266 O  O   . PHE A 1 229 ? 92.693  129.353 112.864 1.00 67.19  ? 229 PHE A O   1 
ATOM   1267 C  CB  . PHE A 1 229 ? 92.554  130.070 109.641 1.00 54.35  ? 229 PHE A CB  1 
ATOM   1268 C  CG  . PHE A 1 229 ? 94.048  129.929 109.650 1.00 61.49  ? 229 PHE A CG  1 
ATOM   1269 C  CD1 . PHE A 1 229 ? 94.643  128.707 109.385 1.00 61.21  ? 229 PHE A CD1 1 
ATOM   1270 C  CD2 . PHE A 1 229 ? 94.858  131.018 109.927 1.00 61.53  ? 229 PHE A CD2 1 
ATOM   1271 C  CE1 . PHE A 1 229 ? 96.018  128.574 109.393 1.00 61.53  ? 229 PHE A CE1 1 
ATOM   1272 C  CE2 . PHE A 1 229 ? 96.234  130.893 109.937 1.00 62.50  ? 229 PHE A CE2 1 
ATOM   1273 C  CZ  . PHE A 1 229 ? 96.815  129.669 109.670 1.00 63.59  ? 229 PHE A CZ  1 
ATOM   1274 N  N   . GLY A 1 230 ? 90.988  130.706 112.313 1.00 64.19  ? 230 GLY A N   1 
ATOM   1275 C  CA  . GLY A 1 230 ? 91.009  131.353 113.614 1.00 53.72  ? 230 GLY A CA  1 
ATOM   1276 C  C   . GLY A 1 230 ? 92.221  132.254 113.764 1.00 59.57  ? 230 GLY A C   1 
ATOM   1277 O  O   . GLY A 1 230 ? 92.659  132.915 112.816 1.00 62.04  ? 230 GLY A O   1 
ATOM   1278 N  N   . GLU A 1 231 ? 92.771  132.286 114.972 1.00 61.60  ? 231 GLU A N   1 
ATOM   1279 C  CA  . GLU A 1 231 ? 93.939  133.090 115.295 1.00 62.83  ? 231 GLU A CA  1 
ATOM   1280 C  C   . GLU A 1 231 ? 95.152  132.194 115.519 1.00 61.69  ? 231 GLU A C   1 
ATOM   1281 O  O   . GLU A 1 231 ? 95.049  130.968 115.596 1.00 61.93  ? 231 GLU A O   1 
ATOM   1282 C  CB  . GLU A 1 231 ? 93.678  133.953 116.534 1.00 61.47  ? 231 GLU A CB  1 
ATOM   1283 C  CG  . GLU A 1 231 ? 93.251  133.160 117.755 1.00 65.43  ? 231 GLU A CG  1 
ATOM   1284 C  CD  . GLU A 1 231 ? 93.794  133.735 119.047 1.00 72.18  ? 231 GLU A CD  1 
ATOM   1285 O  OE1 . GLU A 1 231 ? 94.414  132.976 119.822 1.00 70.86  ? 231 GLU A OE1 1 
ATOM   1286 O  OE2 . GLU A 1 231 ? 93.598  134.944 119.288 1.00 72.96  ? 231 GLU A OE2 1 
ATOM   1287 N  N   . VAL A 1 232 ? 96.313  132.831 115.626 1.00 56.36  ? 232 VAL A N   1 
ATOM   1288 C  CA  . VAL A 1 232 ? 97.574  132.131 115.845 1.00 54.43  ? 232 VAL A CA  1 
ATOM   1289 C  C   . VAL A 1 232 ? 97.880  132.127 117.336 1.00 58.98  ? 232 VAL A C   1 
ATOM   1290 O  O   . VAL A 1 232 ? 97.811  133.169 117.998 1.00 65.26  ? 232 VAL A O   1 
ATOM   1291 C  CB  . VAL A 1 232 ? 98.712  132.789 115.048 1.00 52.75  ? 232 VAL A CB  1 
ATOM   1292 C  CG1 . VAL A 1 232 ? 100.054 132.201 115.448 1.00 58.28  ? 232 VAL A CG1 1 
ATOM   1293 C  CG2 . VAL A 1 232 ? 98.479  132.620 113.557 1.00 55.76  ? 232 VAL A CG2 1 
ATOM   1294 N  N   . ARG A 1 233 ? 98.216  130.954 117.868 1.00 51.73  ? 233 ARG A N   1 
ATOM   1295 C  CA  . ARG A 1 233 ? 98.511  130.796 119.290 1.00 51.21  ? 233 ARG A CA  1 
ATOM   1296 C  C   . ARG A 1 233 ? 99.938  131.262 119.549 1.00 56.12  ? 233 ARG A C   1 
ATOM   1297 O  O   . ARG A 1 233 ? 100.901 130.635 119.106 1.00 58.68  ? 233 ARG A O   1 
ATOM   1298 C  CB  . ARG A 1 233 ? 98.310  129.348 119.717 1.00 50.97  ? 233 ARG A CB  1 
ATOM   1299 C  CG  . ARG A 1 233 ? 96.988  128.750 119.265 1.00 49.61  ? 233 ARG A CG  1 
ATOM   1300 C  CD  . ARG A 1 233 ? 95.889  128.993 120.283 1.00 47.57  ? 233 ARG A CD  1 
ATOM   1301 N  NE  . ARG A 1 233 ? 96.263  128.509 121.606 1.00 57.27  ? 233 ARG A NE  1 
ATOM   1302 C  CZ  . ARG A 1 233 ? 96.429  129.285 122.668 1.00 60.34  ? 233 ARG A CZ  1 
ATOM   1303 N  NH1 . ARG A 1 233 ? 96.237  130.592 122.606 1.00 59.53  ? 233 ARG A NH1 1 
ATOM   1304 N  NH2 . ARG A 1 233 ? 96.797  128.735 123.822 1.00 54.86  ? 233 ARG A NH2 1 
ATOM   1305 N  N   . LEU A 1 234 ? 100.073 132.375 120.270 1.00 43.78  ? 234 LEU A N   1 
ATOM   1306 C  CA  . LEU A 1 234 ? 101.393 132.954 120.506 1.00 46.18  ? 234 LEU A CA  1 
ATOM   1307 C  C   . LEU A 1 234 ? 102.333 132.062 121.315 1.00 57.38  ? 234 LEU A C   1 
ATOM   1308 O  O   . LEU A 1 234 ? 103.507 131.943 120.919 1.00 67.07  ? 234 LEU A O   1 
ATOM   1309 C  CB  . LEU A 1 234 ? 101.235 134.328 121.171 1.00 53.30  ? 234 LEU A CB  1 
ATOM   1310 C  CG  . LEU A 1 234 ? 100.628 135.434 120.307 1.00 50.33  ? 234 LEU A CG  1 
ATOM   1311 C  CD1 . LEU A 1 234 ? 100.760 136.781 120.993 1.00 49.37  ? 234 LEU A CD1 1 
ATOM   1312 C  CD2 . LEU A 1 234 ? 101.276 135.468 118.933 1.00 48.70  ? 234 LEU A CD2 1 
ATOM   1313 N  N   . PRO A 1 235 ? 101.929 131.452 122.439 1.00 52.65  ? 235 PRO A N   1 
ATOM   1314 C  CA  . PRO A 1 235 ? 102.874 130.581 123.161 1.00 36.09  ? 235 PRO A CA  1 
ATOM   1315 C  C   . PRO A 1 235 ? 103.395 129.426 122.327 1.00 45.16  ? 235 PRO A C   1 
ATOM   1316 O  O   . PRO A 1 235 ? 104.575 129.069 122.442 1.00 60.21  ? 235 PRO A O   1 
ATOM   1317 C  CB  . PRO A 1 235 ? 102.046 130.084 124.353 1.00 41.04  ? 235 PRO A CB  1 
ATOM   1318 C  CG  . PRO A 1 235 ? 101.019 131.132 124.553 1.00 43.97  ? 235 PRO A CG  1 
ATOM   1319 C  CD  . PRO A 1 235 ? 100.660 131.589 123.176 1.00 46.22  ? 235 PRO A CD  1 
ATOM   1320 N  N   . LEU A 1 236 ? 102.552 128.835 121.480 1.00 39.76  ? 236 LEU A N   1 
ATOM   1321 C  CA  . LEU A 1 236 ? 103.007 127.760 120.608 1.00 40.74  ? 236 LEU A CA  1 
ATOM   1322 C  C   . LEU A 1 236 ? 104.026 128.262 119.593 1.00 46.98  ? 236 LEU A C   1 
ATOM   1323 O  O   . LEU A 1 236 ? 105.006 127.569 119.300 1.00 60.27  ? 236 LEU A O   1 
ATOM   1324 C  CB  . LEU A 1 236 ? 101.813 127.117 119.905 1.00 47.21  ? 236 LEU A CB  1 
ATOM   1325 C  CG  . LEU A 1 236 ? 100.926 126.248 120.797 1.00 43.86  ? 236 LEU A CG  1 
ATOM   1326 C  CD1 . LEU A 1 236 ? 99.737  125.710 120.019 1.00 47.51  ? 236 LEU A CD1 1 
ATOM   1327 C  CD2 . LEU A 1 236 ? 101.728 125.114 121.412 1.00 40.91  ? 236 LEU A CD2 1 
ATOM   1328 N  N   . LEU A 1 237 ? 103.814 129.463 119.051 1.00 39.60  ? 237 LEU A N   1 
ATOM   1329 C  CA  . LEU A 1 237 ? 104.787 130.042 118.130 1.00 45.53  ? 237 LEU A CA  1 
ATOM   1330 C  C   . LEU A 1 237 ? 106.118 130.305 118.825 1.00 51.25  ? 237 LEU A C   1 
ATOM   1331 O  O   . LEU A 1 237 ? 107.187 130.058 118.252 1.00 53.35  ? 237 LEU A O   1 
ATOM   1332 C  CB  . LEU A 1 237 ? 104.227 131.328 117.523 1.00 46.91  ? 237 LEU A CB  1 
ATOM   1333 C  CG  . LEU A 1 237 ? 105.045 131.977 116.407 1.00 52.86  ? 237 LEU A CG  1 
ATOM   1334 C  CD1 . LEU A 1 237 ? 104.920 131.179 115.124 1.00 47.72  ? 237 LEU A CD1 1 
ATOM   1335 C  CD2 . LEU A 1 237 ? 104.592 133.409 116.193 1.00 52.04  ? 237 LEU A CD2 1 
ATOM   1336 N  N   . GLY A 1 238 ? 106.073 130.805 120.062 1.00 45.49  ? 238 GLY A N   1 
ATOM   1337 C  CA  . GLY A 1 238 ? 107.304 131.005 120.810 1.00 36.14  ? 238 GLY A CA  1 
ATOM   1338 C  C   . GLY A 1 238 ? 108.042 129.707 121.077 1.00 47.69  ? 238 GLY A C   1 
ATOM   1339 O  O   . GLY A 1 238 ? 109.269 129.636 120.944 1.00 54.57  ? 238 GLY A O   1 
ATOM   1340 N  N   . CYS A 1 239 ? 107.304 128.658 121.452 1.00 41.51  ? 239 CYS A N   1 
ATOM   1341 C  CA  . CYS A 1 239 ? 107.923 127.354 121.669 1.00 42.10  ? 239 CYS A CA  1 
ATOM   1342 C  C   . CYS A 1 239 ? 108.538 126.809 120.384 1.00 39.48  ? 239 CYS A C   1 
ATOM   1343 O  O   . CYS A 1 239 ? 109.630 126.230 120.409 1.00 48.87  ? 239 CYS A O   1 
ATOM   1344 C  CB  . CYS A 1 239 ? 106.895 126.374 122.232 1.00 40.40  ? 239 CYS A CB  1 
ATOM   1345 S  SG  . CYS A 1 239 ? 106.402 126.707 123.936 1.00 50.52  ? 239 CYS A SG  1 
ATOM   1346 N  N   . LEU A 1 240 ? 107.850 126.985 119.252 1.00 31.71  ? 240 LEU A N   1 
ATOM   1347 C  CA  . LEU A 1 240 ? 108.390 126.538 117.971 1.00 43.54  ? 240 LEU A CA  1 
ATOM   1348 C  C   . LEU A 1 240 ? 109.676 127.277 117.623 1.00 49.89  ? 240 LEU A C   1 
ATOM   1349 O  O   . LEU A 1 240 ? 110.652 126.666 117.165 1.00 53.22  ? 240 LEU A O   1 
ATOM   1350 C  CB  . LEU A 1 240 ? 107.344 126.735 116.874 1.00 36.61  ? 240 LEU A CB  1 
ATOM   1351 C  CG  . LEU A 1 240 ? 107.623 126.117 115.504 1.00 43.37  ? 240 LEU A CG  1 
ATOM   1352 C  CD1 . LEU A 1 240 ? 107.338 124.629 115.523 1.00 44.83  ? 240 LEU A CD1 1 
ATOM   1353 C  CD2 . LEU A 1 240 ? 106.796 126.808 114.438 1.00 42.99  ? 240 LEU A CD2 1 
ATOM   1354 N  N   . GLY A 1 241 ? 109.694 128.596 117.830 1.00 46.64  ? 241 GLY A N   1 
ATOM   1355 C  CA  . GLY A 1 241 ? 110.907 129.356 117.579 1.00 37.13  ? 241 GLY A CA  1 
ATOM   1356 C  C   . GLY A 1 241 ? 112.060 128.915 118.459 1.00 42.99  ? 241 GLY A C   1 
ATOM   1357 O  O   . GLY A 1 241 ? 113.195 128.782 117.993 1.00 52.50  ? 241 GLY A O   1 
ATOM   1358 N  N   . VAL A 1 242 ? 111.782 128.670 119.742 1.00 43.51  ? 242 VAL A N   1 
ATOM   1359 C  CA  . VAL A 1 242 ? 112.825 128.206 120.655 1.00 46.95  ? 242 VAL A CA  1 
ATOM   1360 C  C   . VAL A 1 242 ? 113.366 126.854 120.206 1.00 47.14  ? 242 VAL A C   1 
ATOM   1361 O  O   . VAL A 1 242 ? 114.582 126.621 120.215 1.00 57.41  ? 242 VAL A O   1 
ATOM   1362 C  CB  . VAL A 1 242 ? 112.286 128.154 122.097 1.00 45.41  ? 242 VAL A CB  1 
ATOM   1363 C  CG1 . VAL A 1 242 ? 113.207 127.336 122.985 1.00 41.38  ? 242 VAL A CG1 1 
ATOM   1364 C  CG2 . VAL A 1 242 ? 112.124 129.559 122.651 1.00 45.90  ? 242 VAL A CG2 1 
ATOM   1365 N  N   . SER A 1 243 ? 112.477 125.944 119.802 1.00 40.68  ? 243 SER A N   1 
ATOM   1366 C  CA  . SER A 1 243 ? 112.911 124.620 119.367 1.00 43.68  ? 243 SER A CA  1 
ATOM   1367 C  C   . SER A 1 243 ? 113.792 124.703 118.124 1.00 46.97  ? 243 SER A C   1 
ATOM   1368 O  O   . SER A 1 243 ? 114.842 124.050 118.044 1.00 47.17  ? 243 SER A O   1 
ATOM   1369 C  CB  . SER A 1 243 ? 111.692 123.736 119.107 1.00 37.95  ? 243 SER A CB  1 
ATOM   1370 O  OG  . SER A 1 243 ? 110.916 124.244 118.039 1.00 52.81  ? 243 SER A OG  1 
ATOM   1371 N  N   . TRP A 1 244 ? 113.381 125.508 117.139 1.00 42.68  ? 244 TRP A N   1 
ATOM   1372 C  CA  . TRP A 1 244 ? 114.176 125.633 115.920 1.00 35.83  ? 244 TRP A CA  1 
ATOM   1373 C  C   . TRP A 1 244 ? 115.526 126.283 116.201 1.00 42.00  ? 244 TRP A C   1 
ATOM   1374 O  O   . TRP A 1 244 ? 116.549 125.873 115.637 1.00 51.48  ? 244 TRP A O   1 
ATOM   1375 C  CB  . TRP A 1 244 ? 113.404 126.418 114.861 1.00 34.37  ? 244 TRP A CB  1 
ATOM   1376 C  CG  . TRP A 1 244 ? 112.520 125.554 114.013 1.00 40.90  ? 244 TRP A CG  1 
ATOM   1377 C  CD1 . TRP A 1 244 ? 111.159 125.504 114.037 1.00 43.85  ? 244 TRP A CD1 1 
ATOM   1378 C  CD2 . TRP A 1 244 ? 112.938 124.609 113.020 1.00 39.29  ? 244 TRP A CD2 1 
ATOM   1379 N  NE1 . TRP A 1 244 ? 110.701 124.590 113.121 1.00 41.09  ? 244 TRP A NE1 1 
ATOM   1380 C  CE2 . TRP A 1 244 ? 111.774 124.027 112.483 1.00 43.05  ? 244 TRP A CE2 1 
ATOM   1381 C  CE3 . TRP A 1 244 ? 114.182 124.201 112.532 1.00 40.43  ? 244 TRP A CE3 1 
ATOM   1382 C  CZ2 . TRP A 1 244 ? 111.817 123.058 111.483 1.00 35.37  ? 244 TRP A CZ2 1 
ATOM   1383 C  CZ3 . TRP A 1 244 ? 114.222 123.240 111.541 1.00 39.66  ? 244 TRP A CZ3 1 
ATOM   1384 C  CH2 . TRP A 1 244 ? 113.048 122.679 111.027 1.00 35.82  ? 244 TRP A CH2 1 
ATOM   1385 N  N   . LEU A 1 245 ? 115.552 127.294 117.075 1.00 45.08  ? 245 LEU A N   1 
ATOM   1386 C  CA  . LEU A 1 245 ? 116.818 127.924 117.438 1.00 40.55  ? 245 LEU A CA  1 
ATOM   1387 C  C   . LEU A 1 245 ? 117.749 126.936 118.129 1.00 45.55  ? 245 LEU A C   1 
ATOM   1388 O  O   . LEU A 1 245 ? 118.956 126.909 117.851 1.00 50.69  ? 245 LEU A O   1 
ATOM   1389 C  CB  . LEU A 1 245 ? 116.556 129.133 118.335 1.00 39.40  ? 245 LEU A CB  1 
ATOM   1390 C  CG  . LEU A 1 245 ? 117.758 129.975 118.757 1.00 45.03  ? 245 LEU A CG  1 
ATOM   1391 C  CD1 . LEU A 1 245 ? 118.421 130.612 117.549 1.00 48.53  ? 245 LEU A CD1 1 
ATOM   1392 C  CD2 . LEU A 1 245 ? 117.328 131.035 119.756 1.00 47.38  ? 245 LEU A CD2 1 
ATOM   1393 N  N   . VAL A 1 246 ? 117.208 126.118 119.035 1.00 48.61  ? 246 VAL A N   1 
ATOM   1394 C  CA  . VAL A 1 246 ? 118.021 125.117 119.722 1.00 48.44  ? 246 VAL A CA  1 
ATOM   1395 C  C   . VAL A 1 246 ? 118.604 124.127 118.722 1.00 51.24  ? 246 VAL A C   1 
ATOM   1396 O  O   . VAL A 1 246 ? 119.796 123.793 118.778 1.00 59.36  ? 246 VAL A O   1 
ATOM   1397 C  CB  . VAL A 1 246 ? 117.187 124.407 120.805 1.00 41.97  ? 246 VAL A CB  1 
ATOM   1398 C  CG1 . VAL A 1 246 ? 117.752 123.028 121.102 1.00 42.98  ? 246 VAL A CG1 1 
ATOM   1399 C  CG2 . VAL A 1 246 ? 117.135 125.246 122.070 1.00 46.76  ? 246 VAL A CG2 1 
ATOM   1400 N  N   . VAL A 1 247 ? 117.777 123.651 117.786 1.00 49.18  ? 247 VAL A N   1 
ATOM   1401 C  CA  . VAL A 1 247 ? 118.258 122.694 116.790 1.00 53.06  ? 247 VAL A CA  1 
ATOM   1402 C  C   . VAL A 1 247 ? 119.372 123.311 115.952 1.00 53.99  ? 247 VAL A C   1 
ATOM   1403 O  O   . VAL A 1 247 ? 120.416 122.687 115.717 1.00 55.00  ? 247 VAL A O   1 
ATOM   1404 C  CB  . VAL A 1 247 ? 117.094 122.204 115.908 1.00 53.80  ? 247 VAL A CB  1 
ATOM   1405 C  CG1 . VAL A 1 247 ? 117.621 121.545 114.646 1.00 53.92  ? 247 VAL A CG1 1 
ATOM   1406 C  CG2 . VAL A 1 247 ? 116.218 121.237 116.678 1.00 53.81  ? 247 VAL A CG2 1 
ATOM   1407 N  N   . PHE A 1 248 ? 119.174 124.553 115.502 1.00 54.11  ? 248 PHE A N   1 
ATOM   1408 C  CA  . PHE A 1 248 ? 120.172 125.210 114.662 1.00 51.82  ? 248 PHE A CA  1 
ATOM   1409 C  C   . PHE A 1 248 ? 121.493 125.385 115.403 1.00 55.42  ? 248 PHE A C   1 
ATOM   1410 O  O   . PHE A 1 248 ? 122.568 125.099 114.857 1.00 62.22  ? 248 PHE A O   1 
ATOM   1411 C  CB  . PHE A 1 248 ? 119.640 126.562 114.186 1.00 52.06  ? 248 PHE A CB  1 
ATOM   1412 C  CG  . PHE A 1 248 ? 120.683 127.441 113.557 1.00 52.84  ? 248 PHE A CG  1 
ATOM   1413 C  CD1 . PHE A 1 248 ? 121.116 127.207 112.266 1.00 46.40  ? 248 PHE A CD1 1 
ATOM   1414 C  CD2 . PHE A 1 248 ? 121.226 128.505 114.257 1.00 57.42  ? 248 PHE A CD2 1 
ATOM   1415 C  CE1 . PHE A 1 248 ? 122.071 128.017 111.685 1.00 51.77  ? 248 PHE A CE1 1 
ATOM   1416 C  CE2 . PHE A 1 248 ? 122.184 129.315 113.682 1.00 51.43  ? 248 PHE A CE2 1 
ATOM   1417 C  CZ  . PHE A 1 248 ? 122.606 129.070 112.394 1.00 48.63  ? 248 PHE A CZ  1 
ATOM   1418 N  N   . LEU A 1 249 ? 121.433 125.863 116.649 1.00 56.31  ? 249 LEU A N   1 
ATOM   1419 C  CA  . LEU A 1 249 ? 122.661 126.083 117.406 1.00 53.50  ? 249 LEU A CA  1 
ATOM   1420 C  C   . LEU A 1 249 ? 123.393 124.772 117.663 1.00 61.01  ? 249 LEU A C   1 
ATOM   1421 O  O   . LEU A 1 249 ? 124.618 124.694 117.502 1.00 63.48  ? 249 LEU A O   1 
ATOM   1422 C  CB  . LEU A 1 249 ? 122.350 126.793 118.722 1.00 49.99  ? 249 LEU A CB  1 
ATOM   1423 C  CG  . LEU A 1 249 ? 122.107 128.299 118.622 1.00 54.48  ? 249 LEU A CG  1 
ATOM   1424 C  CD1 . LEU A 1 249 ? 121.525 128.834 119.917 1.00 56.38  ? 249 LEU A CD1 1 
ATOM   1425 C  CD2 . LEU A 1 249 ? 123.392 129.025 118.266 1.00 57.72  ? 249 LEU A CD2 1 
ATOM   1426 N  N   . CYS A 1 250 ? 122.657 123.725 118.046 1.00 68.90  ? 250 CYS A N   1 
ATOM   1427 C  CA  . CYS A 1 250 ? 123.292 122.435 118.292 1.00 66.58  ? 250 CYS A CA  1 
ATOM   1428 C  C   . CYS A 1 250 ? 123.928 121.880 117.025 1.00 68.00  ? 250 CYS A C   1 
ATOM   1429 O  O   . CYS A 1 250 ? 124.997 121.262 117.079 1.00 69.75  ? 250 CYS A O   1 
ATOM   1430 C  CB  . CYS A 1 250 ? 122.273 121.448 118.857 1.00 61.74  ? 250 CYS A CB  1 
ATOM   1431 S  SG  . CYS A 1 250 ? 122.003 121.582 120.637 1.00 81.51  ? 250 CYS A SG  1 
ATOM   1432 N  N   . LEU A 1 251 ? 123.286 122.085 115.872 1.00 67.73  ? 251 LEU A N   1 
ATOM   1433 C  CA  . LEU A 1 251 ? 123.845 121.572 114.626 1.00 62.53  ? 251 LEU A CA  1 
ATOM   1434 C  C   . LEU A 1 251 ? 125.106 122.328 114.224 1.00 62.48  ? 251 LEU A C   1 
ATOM   1435 O  O   . LEU A 1 251 ? 126.091 121.718 113.793 1.00 63.67  ? 251 LEU A O   1 
ATOM   1436 C  CB  . LEU A 1 251 ? 122.803 121.635 113.511 1.00 62.66  ? 251 LEU A CB  1 
ATOM   1437 C  CG  . LEU A 1 251 ? 122.148 120.294 113.181 1.00 66.13  ? 251 LEU A CG  1 
ATOM   1438 C  CD1 . LEU A 1 251 ? 120.861 120.501 112.412 1.00 69.26  ? 251 LEU A CD1 1 
ATOM   1439 C  CD2 . LEU A 1 251 ? 123.106 119.415 112.398 1.00 62.26  ? 251 LEU A CD2 1 
ATOM   1440 N  N   . ILE A 1 252 ? 125.102 123.654 114.354 1.00 69.29  ? 252 ILE A N   1 
ATOM   1441 C  CA  . ILE A 1 252 ? 126.230 124.431 113.846 1.00 65.25  ? 252 ILE A CA  1 
ATOM   1442 C  C   . ILE A 1 252 ? 127.346 124.537 114.879 1.00 69.75  ? 252 ILE A C   1 
ATOM   1443 O  O   . ILE A 1 252 ? 128.420 125.071 114.583 1.00 71.48  ? 252 ILE A O   1 
ATOM   1444 C  CB  . ILE A 1 252 ? 125.779 125.824 113.359 1.00 58.61  ? 252 ILE A CB  1 
ATOM   1445 C  CG1 . ILE A 1 252 ? 125.518 126.781 114.528 1.00 65.21  ? 252 ILE A CG1 1 
ATOM   1446 C  CG2 . ILE A 1 252 ? 124.577 125.704 112.436 1.00 68.43  ? 252 ILE A CG2 1 
ATOM   1447 C  CD1 . ILE A 1 252 ? 126.655 127.747 114.819 1.00 68.18  ? 252 ILE A CD1 1 
ATOM   1448 N  N   . ARG A 1 253 ? 127.122 124.024 116.091 1.00 85.86  ? 253 ARG A N   1 
ATOM   1449 C  CA  . ARG A 1 253 ? 128.186 123.974 117.093 1.00 84.09  ? 253 ARG A CA  1 
ATOM   1450 C  C   . ARG A 1 253 ? 128.578 122.515 117.358 1.00 84.45  ? 253 ARG A C   1 
ATOM   1451 O  O   . ARG A 1 253 ? 129.435 122.203 118.181 1.00 83.26  ? 253 ARG A O   1 
ATOM   1452 C  CB  . ARG A 1 253 ? 127.772 124.724 118.361 1.00 80.05  ? 253 ARG A CB  1 
ATOM   1453 C  CG  . ARG A 1 253 ? 127.317 123.873 119.534 1.00 82.13  ? 253 ARG A CG  1 
ATOM   1454 C  CD  . ARG A 1 253 ? 126.829 124.762 120.668 1.00 86.90  ? 253 ARG A CD  1 
ATOM   1455 N  NE  . ARG A 1 253 ? 125.870 124.088 121.533 1.00 90.89  ? 253 ARG A NE  1 
ATOM   1456 C  CZ  . ARG A 1 253 ? 125.149 124.697 122.464 1.00 88.45  ? 253 ARG A CZ  1 
ATOM   1457 N  NH1 . ARG A 1 253 ? 125.257 125.997 122.681 1.00 84.43  ? 253 ARG A NH1 1 
ATOM   1458 N  NH2 . ARG A 1 253 ? 124.296 123.984 123.194 1.00 84.66  ? 253 ARG A NH2 1 
ATOM   1459 N  N   . GLY A 1 254 ? 127.969 121.601 116.604 1.00 93.73  ? 254 GLY A N   1 
ATOM   1460 C  CA  . GLY A 1 254 ? 128.331 120.194 116.640 1.00 92.41  ? 254 GLY A CA  1 
ATOM   1461 C  C   . GLY A 1 254 ? 128.202 119.529 117.996 1.00 94.61  ? 254 GLY A C   1 
ATOM   1462 O  O   . GLY A 1 254 ? 129.203 119.115 118.588 1.00 95.59  ? 254 GLY A O   1 
ATOM   1463 N  N   . VAL A 1 255 ? 126.974 119.418 118.497 1.00 97.85  ? 255 VAL A N   1 
ATOM   1464 C  CA  . VAL A 1 255 ? 126.720 118.833 119.810 1.00 96.59  ? 255 VAL A CA  1 
ATOM   1465 C  C   . VAL A 1 255 ? 126.796 117.313 119.812 1.00 98.75  ? 255 VAL A C   1 
ATOM   1466 O  O   . VAL A 1 255 ? 127.398 116.743 120.738 1.00 98.74  ? 255 VAL A O   1 
ATOM   1467 C  CB  . VAL A 1 255 ? 125.361 119.299 120.378 1.00 95.51  ? 255 VAL A CB  1 
ATOM   1468 C  CG1 . VAL A 1 255 ? 124.203 118.832 119.503 1.00 93.54  ? 255 VAL A CG1 1 
ATOM   1469 C  CG2 . VAL A 1 255 ? 125.187 118.799 121.805 1.00 93.82  ? 255 VAL A CG2 1 
ATOM   1470 N  N   . LYS A 1 256 ? 126.234 116.636 118.810 1.00 101.23 ? 256 LYS A N   1 
ATOM   1471 C  CA  . LYS A 1 256 ? 126.149 115.178 118.822 1.00 102.05 ? 256 LYS A CA  1 
ATOM   1472 C  C   . LYS A 1 256 ? 127.309 114.522 118.086 1.00 104.37 ? 256 LYS A C   1 
ATOM   1473 O  O   . LYS A 1 256 ? 127.842 113.518 118.570 1.00 103.12 ? 256 LYS A O   1 
ATOM   1474 C  CB  . LYS A 1 256 ? 124.810 114.722 118.227 1.00 101.90 ? 256 LYS A CB  1 
ATOM   1475 C  CG  . LYS A 1 256 ? 124.603 113.215 118.265 1.00 101.14 ? 256 LYS A CG  1 
ATOM   1476 C  CD  . LYS A 1 256 ? 123.246 112.826 117.710 1.00 102.75 ? 256 LYS A CD  1 
ATOM   1477 C  CE  . LYS A 1 256 ? 123.052 111.320 117.727 1.00 103.29 ? 256 LYS A CE  1 
ATOM   1478 N  NZ  . LYS A 1 256 ? 121.722 110.931 117.184 1.00 100.64 ? 256 LYS A NZ  1 
ATOM   1479 N  N   . SER A 1 257 ? 127.711 115.047 116.927 1.00 113.56 ? 257 SER A N   1 
ATOM   1480 C  CA  . SER A 1 257 ? 128.785 114.449 116.141 1.00 112.81 ? 257 SER A CA  1 
ATOM   1481 C  C   . SER A 1 257 ? 130.072 114.356 116.951 1.00 113.00 ? 257 SER A C   1 
ATOM   1482 O  O   . SER A 1 257 ? 130.572 113.257 117.209 1.00 112.42 ? 257 SER A O   1 
ATOM   1483 C  CB  . SER A 1 257 ? 129.018 115.249 114.858 1.00 112.22 ? 257 SER A CB  1 
ATOM   1484 O  OG  . SER A 1 257 ? 128.290 114.697 113.773 1.00 109.51 ? 257 SER A OG  1 
ATOM   1485 N  N   . SER A 1 258 ? 130.615 115.504 117.352 1.00 114.70 ? 258 SER A N   1 
ATOM   1486 C  CA  . SER A 1 258 ? 131.748 115.532 118.268 1.00 114.52 ? 258 SER A CA  1 
ATOM   1487 C  C   . SER A 1 258 ? 131.263 115.796 119.687 1.00 116.48 ? 258 SER A C   1 
ATOM   1488 O  O   . SER A 1 258 ? 131.577 116.837 120.273 1.00 113.57 ? 258 SER A O   1 
ATOM   1489 C  CB  . SER A 1 258 ? 132.763 116.592 117.839 1.00 111.88 ? 258 SER A CB  1 
ATOM   1490 O  OG  . SER A 1 258 ? 132.239 117.897 118.009 1.00 114.40 ? 258 SER A OG  1 
ATOM   1491 N  N   . GLY A 1 259 ? 130.494 114.864 120.247 1.00 120.74 ? 259 GLY A N   1 
ATOM   1492 C  CA  . GLY A 1 259 ? 129.922 115.062 121.564 1.00 119.35 ? 259 GLY A CA  1 
ATOM   1493 C  C   . GLY A 1 259 ? 129.638 113.750 122.260 1.00 119.58 ? 259 GLY A C   1 
ATOM   1494 O  O   . GLY A 1 259 ? 129.680 112.673 121.656 1.00 115.98 ? 259 GLY A O   1 
ATOM   1495 N  N   . LYS A 1 260 ? 129.341 113.859 123.554 1.00 130.24 ? 260 LYS A N   1 
ATOM   1496 C  CA  . LYS A 1 260 ? 129.109 112.703 124.411 1.00 131.62 ? 260 LYS A CA  1 
ATOM   1497 C  C   . LYS A 1 260 ? 127.693 112.770 124.979 1.00 130.15 ? 260 LYS A C   1 
ATOM   1498 O  O   . LYS A 1 260 ? 126.857 113.506 124.448 1.00 127.87 ? 260 LYS A O   1 
ATOM   1499 C  CB  . LYS A 1 260 ? 130.159 112.641 125.525 1.00 130.66 ? 260 LYS A CB  1 
ATOM   1500 C  CG  . LYS A 1 260 ? 130.398 111.245 126.094 1.00 128.93 ? 260 LYS A CG  1 
ATOM   1501 C  CD  . LYS A 1 260 ? 131.079 111.299 127.450 1.00 129.69 ? 260 LYS A CD  1 
ATOM   1502 C  CE  . LYS A 1 260 ? 130.204 110.690 128.530 1.00 128.84 ? 260 LYS A CE  1 
ATOM   1503 N  NZ  . LYS A 1 260 ? 130.144 109.205 128.416 1.00 128.68 ? 260 LYS A NZ  1 
ATOM   1504 N  N   . VAL A 1 261 ? 127.413 111.940 125.992 1.00 118.88 ? 261 VAL A N   1 
ATOM   1505 C  CA  . VAL A 1 261 ? 126.186 111.847 126.793 1.00 119.10 ? 261 VAL A CA  1 
ATOM   1506 C  C   . VAL A 1 261 ? 125.118 111.439 125.785 1.00 119.11 ? 261 VAL A C   1 
ATOM   1507 O  O   . VAL A 1 261 ? 123.943 111.803 125.921 1.00 116.00 ? 261 VAL A O   1 
ATOM   1508 C  CB  . VAL A 1 261 ? 125.721 113.201 127.387 1.00 118.88 ? 261 VAL A CB  1 
ATOM   1509 C  CG1 . VAL A 1 261 ? 126.883 113.953 128.049 1.00 115.95 ? 261 VAL A CG1 1 
ATOM   1510 C  CG2 . VAL A 1 261 ? 124.886 114.064 126.420 1.00 118.14 ? 261 VAL A CG2 1 
ATOM   1511 N  N   . VAL A 1 262 ? 125.502 110.519 124.869 1.00 116.28 ? 262 VAL A N   1 
ATOM   1512 C  CA  . VAL A 1 262 ? 124.524 109.793 124.072 1.00 114.49 ? 262 VAL A CA  1 
ATOM   1513 C  C   . VAL A 1 262 ? 124.161 108.561 124.886 1.00 112.72 ? 262 VAL A C   1 
ATOM   1514 O  O   . VAL A 1 262 ? 123.084 107.986 124.695 1.00 112.62 ? 262 VAL A O   1 
ATOM   1515 C  CB  . VAL A 1 262 ? 125.124 109.396 122.708 1.00 112.79 ? 262 VAL A CB  1 
ATOM   1516 C  CG1 . VAL A 1 262 ? 124.142 108.534 121.930 1.00 111.34 ? 262 VAL A CG1 1 
ATOM   1517 C  CG2 . VAL A 1 262 ? 125.501 110.638 121.913 1.00 112.22 ? 262 VAL A CG2 1 
ATOM   1518 N  N   . TYR A 1 263 ? 125.044 108.136 125.794 1.00 105.83 ? 263 TYR A N   1 
ATOM   1519 C  CA  . TYR A 1 263 ? 124.721 107.036 126.697 1.00 106.55 ? 263 TYR A CA  1 
ATOM   1520 C  C   . TYR A 1 263 ? 123.593 107.415 127.650 1.00 107.58 ? 263 TYR A C   1 
ATOM   1521 O  O   . TYR A 1 263 ? 122.666 106.626 127.872 1.00 106.49 ? 263 TYR A O   1 
ATOM   1522 C  CB  . TYR A 1 263 ? 125.972 106.626 127.475 1.00 104.65 ? 263 TYR A CB  1 
ATOM   1523 C  CG  . TYR A 1 263 ? 125.872 105.283 128.158 1.00 107.30 ? 263 TYR A CG  1 
ATOM   1524 C  CD1 . TYR A 1 263 ? 126.257 104.120 127.504 1.00 107.96 ? 263 TYR A CD1 1 
ATOM   1525 C  CD2 . TYR A 1 263 ? 125.399 105.177 129.460 1.00 107.19 ? 263 TYR A CD2 1 
ATOM   1526 C  CE1 . TYR A 1 263 ? 126.171 102.889 128.125 1.00 107.37 ? 263 TYR A CE1 1 
ATOM   1527 C  CE2 . TYR A 1 263 ? 125.309 103.949 130.089 1.00 108.70 ? 263 TYR A CE2 1 
ATOM   1528 C  CZ  . TYR A 1 263 ? 125.696 102.809 129.417 1.00 108.74 ? 263 TYR A CZ  1 
ATOM   1529 O  OH  . TYR A 1 263 ? 125.609 101.584 130.038 1.00 107.55 ? 263 TYR A OH  1 
ATOM   1530 N  N   . PHE A 1 264 ? 123.656 108.616 128.227 1.00 104.57 ? 264 PHE A N   1 
ATOM   1531 C  CA  . PHE A 1 264 ? 122.583 109.074 129.104 1.00 102.12 ? 264 PHE A CA  1 
ATOM   1532 C  C   . PHE A 1 264 ? 121.290 109.294 128.328 1.00 101.45 ? 264 PHE A C   1 
ATOM   1533 O  O   . PHE A 1 264 ? 120.205 108.949 128.812 1.00 99.23  ? 264 PHE A O   1 
ATOM   1534 C  CB  . PHE A 1 264 ? 123.015 110.351 129.832 1.00 99.88  ? 264 PHE A CB  1 
ATOM   1535 C  CG  . PHE A 1 264 ? 121.896 111.323 130.086 1.00 100.05 ? 264 PHE A CG  1 
ATOM   1536 C  CD1 . PHE A 1 264 ? 121.081 111.185 131.197 1.00 102.27 ? 264 PHE A CD1 1 
ATOM   1537 C  CD2 . PHE A 1 264 ? 121.679 112.393 129.233 1.00 99.73  ? 264 PHE A CD2 1 
ATOM   1538 C  CE1 . PHE A 1 264 ? 120.057 112.079 131.439 1.00 103.62 ? 264 PHE A CE1 1 
ATOM   1539 C  CE2 . PHE A 1 264 ? 120.655 113.290 129.470 1.00 98.95  ? 264 PHE A CE2 1 
ATOM   1540 C  CZ  . PHE A 1 264 ? 119.844 113.134 130.575 1.00 102.41 ? 264 PHE A CZ  1 
ATOM   1541 N  N   . THR A 1 265 ? 121.386 109.847 127.117 1.00 103.14 ? 265 THR A N   1 
ATOM   1542 C  CA  . THR A 1 265 ? 120.202 110.064 126.291 1.00 104.58 ? 265 THR A CA  1 
ATOM   1543 C  C   . THR A 1 265 ? 119.719 108.761 125.663 1.00 105.61 ? 265 THR A C   1 
ATOM   1544 O  O   . THR A 1 265 ? 118.827 108.772 124.808 1.00 104.51 ? 265 THR A O   1 
ATOM   1545 C  CB  . THR A 1 265 ? 120.472 111.099 125.195 1.00 106.64 ? 265 THR A CB  1 
ATOM   1546 O  OG1 . THR A 1 265 ? 121.343 110.540 124.204 1.00 106.12 ? 265 THR A OG1 1 
ATOM   1547 C  CG2 . THR A 1 265 ? 121.095 112.356 125.777 1.00 104.83 ? 265 THR A CG2 1 
ATOM   1548 N  N   . ALA A 1 266 ? 120.304 107.637 126.073 1.00 100.63 ? 266 ALA A N   1 
ATOM   1549 C  CA  . ALA A 1 266 ? 119.840 106.328 125.633 1.00 99.29  ? 266 ALA A CA  1 
ATOM   1550 C  C   . ALA A 1 266 ? 119.383 105.506 126.830 1.00 97.81  ? 266 ALA A C   1 
ATOM   1551 O  O   . ALA A 1 266 ? 118.621 104.547 126.679 1.00 100.93 ? 266 ALA A O   1 
ATOM   1552 C  CB  . ALA A 1 266 ? 120.940 105.591 124.867 1.00 99.11  ? 266 ALA A CB  1 
ATOM   1553 N  N   . THR A 1 267 ? 119.854 105.869 128.022 1.00 89.27  ? 267 THR A N   1 
ATOM   1554 C  CA  . THR A 1 267 ? 119.484 105.159 129.239 1.00 91.72  ? 267 THR A CA  1 
ATOM   1555 C  C   . THR A 1 267 ? 118.336 105.811 130.004 1.00 92.77  ? 267 THR A C   1 
ATOM   1556 O  O   . THR A 1 267 ? 117.572 105.096 130.661 1.00 89.65  ? 267 THR A O   1 
ATOM   1557 C  CB  . THR A 1 267 ? 120.699 105.032 130.166 1.00 91.08  ? 267 THR A CB  1 
ATOM   1558 O  OG1 . THR A 1 267 ? 121.885 104.871 129.379 1.00 94.81  ? 267 THR A OG1 1 
ATOM   1559 C  CG2 . THR A 1 267 ? 120.547 103.829 131.081 1.00 89.46  ? 267 THR A CG2 1 
ATOM   1560 N  N   . PHE A 1 268 ? 118.189 107.136 129.935 1.00 81.39  ? 268 PHE A N   1 
ATOM   1561 C  CA  . PHE A 1 268 ? 117.167 107.872 130.679 1.00 76.58  ? 268 PHE A CA  1 
ATOM   1562 C  C   . PHE A 1 268 ? 115.730 107.462 130.339 1.00 82.17  ? 268 PHE A C   1 
ATOM   1563 O  O   . PHE A 1 268 ? 114.916 107.272 131.261 1.00 82.82  ? 268 PHE A O   1 
ATOM   1564 C  CB  . PHE A 1 268 ? 117.363 109.374 130.445 1.00 76.57  ? 268 PHE A CB  1 
ATOM   1565 C  CG  . PHE A 1 268 ? 116.532 110.247 131.338 1.00 79.04  ? 268 PHE A CG  1 
ATOM   1566 C  CD1 . PHE A 1 268 ? 116.650 110.165 132.714 1.00 80.20  ? 268 PHE A CD1 1 
ATOM   1567 C  CD2 . PHE A 1 268 ? 115.646 111.165 130.799 1.00 77.58  ? 268 PHE A CD2 1 
ATOM   1568 C  CE1 . PHE A 1 268 ? 115.891 110.972 133.537 1.00 80.12  ? 268 PHE A CE1 1 
ATOM   1569 C  CE2 . PHE A 1 268 ? 114.885 111.974 131.616 1.00 79.32  ? 268 PHE A CE2 1 
ATOM   1570 C  CZ  . PHE A 1 268 ? 115.007 111.878 132.986 1.00 81.54  ? 268 PHE A CZ  1 
ATOM   1571 N  N   . PRO A 1 269 ? 115.362 107.333 129.052 1.00 74.36  ? 269 PRO A N   1 
ATOM   1572 C  CA  . PRO A 1 269 ? 113.959 107.006 128.740 1.00 68.05  ? 269 PRO A CA  1 
ATOM   1573 C  C   . PRO A 1 269 ? 113.476 105.712 129.363 1.00 70.10  ? 269 PRO A C   1 
ATOM   1574 O  O   . PRO A 1 269 ? 112.318 105.631 129.789 1.00 74.52  ? 269 PRO A O   1 
ATOM   1575 C  CB  . PRO A 1 269 ? 113.955 106.927 127.207 1.00 65.90  ? 269 PRO A CB  1 
ATOM   1576 C  CG  . PRO A 1 269 ? 115.064 107.805 126.793 1.00 72.60  ? 269 PRO A CG  1 
ATOM   1577 C  CD  . PRO A 1 269 ? 116.130 107.579 127.816 1.00 73.40  ? 269 PRO A CD  1 
ATOM   1578 N  N   . TYR A 1 270 ? 114.332 104.693 129.433 1.00 72.76  ? 270 TYR A N   1 
ATOM   1579 C  CA  . TYR A 1 270 ? 113.908 103.422 130.009 1.00 70.03  ? 270 TYR A CA  1 
ATOM   1580 C  C   . TYR A 1 270 ? 113.690 103.540 131.511 1.00 69.49  ? 270 TYR A C   1 
ATOM   1581 O  O   . TYR A 1 270 ? 112.772 102.920 132.056 1.00 71.82  ? 270 TYR A O   1 
ATOM   1582 C  CB  . TYR A 1 270 ? 114.926 102.333 129.678 1.00 73.48  ? 270 TYR A CB  1 
ATOM   1583 C  CG  . TYR A 1 270 ? 115.110 102.142 128.190 1.00 75.36  ? 270 TYR A CG  1 
ATOM   1584 C  CD1 . TYR A 1 270 ? 114.250 101.331 127.464 1.00 71.09  ? 270 TYR A CD1 1 
ATOM   1585 C  CD2 . TYR A 1 270 ? 116.131 102.789 127.509 1.00 71.84  ? 270 TYR A CD2 1 
ATOM   1586 C  CE1 . TYR A 1 270 ? 114.408 101.160 126.105 1.00 72.12  ? 270 TYR A CE1 1 
ATOM   1587 C  CE2 . TYR A 1 270 ? 116.295 102.624 126.150 1.00 69.12  ? 270 TYR A CE2 1 
ATOM   1588 C  CZ  . TYR A 1 270 ? 115.433 101.810 125.452 1.00 72.11  ? 270 TYR A CZ  1 
ATOM   1589 O  OH  . TYR A 1 270 ? 115.599 101.646 124.097 1.00 78.26  ? 270 TYR A OH  1 
ATOM   1590 N  N   . VAL A 1 271 ? 114.505 104.346 132.195 1.00 71.95  ? 271 VAL A N   1 
ATOM   1591 C  CA  . VAL A 1 271 ? 114.277 104.587 133.618 1.00 71.11  ? 271 VAL A CA  1 
ATOM   1592 C  C   . VAL A 1 271 ? 112.949 105.303 133.831 1.00 75.62  ? 271 VAL A C   1 
ATOM   1593 O  O   . VAL A 1 271 ? 112.168 104.942 134.723 1.00 75.28  ? 271 VAL A O   1 
ATOM   1594 C  CB  . VAL A 1 271 ? 115.448 105.379 134.227 1.00 71.01  ? 271 VAL A CB  1 
ATOM   1595 C  CG1 . VAL A 1 271 ? 115.383 105.328 135.743 1.00 70.98  ? 271 VAL A CG1 1 
ATOM   1596 C  CG2 . VAL A 1 271 ? 116.771 104.824 133.739 1.00 74.42  ? 271 VAL A CG2 1 
ATOM   1597 N  N   . VAL A 1 272 ? 112.668 106.326 133.017 1.00 68.31  ? 272 VAL A N   1 
ATOM   1598 C  CA  . VAL A 1 272 ? 111.408 107.054 133.169 1.00 65.20  ? 272 VAL A CA  1 
ATOM   1599 C  C   . VAL A 1 272 ? 110.220 106.133 132.907 1.00 69.02  ? 272 VAL A C   1 
ATOM   1600 O  O   . VAL A 1 272 ? 109.228 106.139 133.652 1.00 66.95  ? 272 VAL A O   1 
ATOM   1601 C  CB  . VAL A 1 272 ? 111.387 108.287 132.247 1.00 63.96  ? 272 VAL A CB  1 
ATOM   1602 C  CG1 . VAL A 1 272 ? 110.010 108.924 132.242 1.00 61.76  ? 272 VAL A CG1 1 
ATOM   1603 C  CG2 . VAL A 1 272 ? 112.437 109.294 132.685 1.00 63.67  ? 272 VAL A CG2 1 
ATOM   1604 N  N   . LEU A 1 273 ? 110.303 105.322 131.849 1.00 65.65  ? 273 LEU A N   1 
ATOM   1605 C  CA  . LEU A 1 273 ? 109.217 104.403 131.527 1.00 59.47  ? 273 LEU A CA  1 
ATOM   1606 C  C   . LEU A 1 273 ? 109.032 103.343 132.605 1.00 61.62  ? 273 LEU A C   1 
ATOM   1607 O  O   . LEU A 1 273 ? 107.896 102.971 132.910 1.00 62.66  ? 273 LEU A O   1 
ATOM   1608 C  CB  . LEU A 1 273 ? 109.469 103.744 130.172 1.00 59.89  ? 273 LEU A CB  1 
ATOM   1609 C  CG  . LEU A 1 273 ? 109.065 104.560 128.942 1.00 62.86  ? 273 LEU A CG  1 
ATOM   1610 C  CD1 . LEU A 1 273 ? 109.426 103.822 127.662 1.00 60.86  ? 273 LEU A CD1 1 
ATOM   1611 C  CD2 . LEU A 1 273 ? 107.582 104.889 128.977 1.00 60.00  ? 273 LEU A CD2 1 
ATOM   1612 N  N   . THR A 1 274 ? 110.125 102.838 133.185 1.00 66.19  ? 274 THR A N   1 
ATOM   1613 C  CA  . THR A 1 274 ? 110.007 101.872 134.272 1.00 66.00  ? 274 THR A CA  1 
ATOM   1614 C  C   . THR A 1 274 ? 109.359 102.501 135.498 1.00 68.77  ? 274 THR A C   1 
ATOM   1615 O  O   . THR A 1 274 ? 108.553 101.857 136.180 1.00 69.75  ? 274 THR A O   1 
ATOM   1616 C  CB  . THR A 1 274 ? 111.381 101.306 134.625 1.00 67.89  ? 274 THR A CB  1 
ATOM   1617 O  OG1 . THR A 1 274 ? 111.942 100.663 133.474 1.00 77.13  ? 274 THR A OG1 1 
ATOM   1618 C  CG2 . THR A 1 274 ? 111.269 100.294 135.754 1.00 64.87  ? 274 THR A CG2 1 
ATOM   1619 N  N   . ILE A 1 275 ? 109.700 103.756 135.797 1.00 72.42  ? 275 ILE A N   1 
ATOM   1620 C  CA  . ILE A 1 275 ? 109.066 104.444 136.917 1.00 68.99  ? 275 ILE A CA  1 
ATOM   1621 C  C   . ILE A 1 275 ? 107.570 104.595 136.672 1.00 69.12  ? 275 ILE A C   1 
ATOM   1622 O  O   . ILE A 1 275 ? 106.753 104.375 137.575 1.00 69.96  ? 275 ILE A O   1 
ATOM   1623 C  CB  . ILE A 1 275 ? 109.745 105.803 137.163 1.00 69.15  ? 275 ILE A CB  1 
ATOM   1624 C  CG1 . ILE A 1 275 ? 111.067 105.611 137.908 1.00 70.92  ? 275 ILE A CG1 1 
ATOM   1625 C  CG2 . ILE A 1 275 ? 108.831 106.725 137.952 1.00 68.95  ? 275 ILE A CG2 1 
ATOM   1626 C  CD1 . ILE A 1 275 ? 110.988 104.624 139.051 1.00 68.69  ? 275 ILE A CD1 1 
ATOM   1627 N  N   . LEU A 1 276 ? 107.184 104.965 135.448 1.00 70.77  ? 276 LEU A N   1 
ATOM   1628 C  CA  . LEU A 1 276 ? 105.761 105.107 135.143 1.00 72.80  ? 276 LEU A CA  1 
ATOM   1629 C  C   . LEU A 1 276 ? 105.048 103.760 135.080 1.00 74.95  ? 276 LEU A C   1 
ATOM   1630 O  O   . LEU A 1 276 ? 103.826 103.700 135.254 1.00 70.41  ? 276 LEU A O   1 
ATOM   1631 C  CB  . LEU A 1 276 ? 105.574 105.856 133.824 1.00 73.28  ? 276 LEU A CB  1 
ATOM   1632 C  CG  . LEU A 1 276 ? 105.466 107.378 133.906 1.00 69.21  ? 276 LEU A CG  1 
ATOM   1633 C  CD1 . LEU A 1 276 ? 105.389 107.976 132.512 1.00 67.55  ? 276 LEU A CD1 1 
ATOM   1634 C  CD2 . LEU A 1 276 ? 104.261 107.784 134.736 1.00 64.41  ? 276 LEU A CD2 1 
ATOM   1635 N  N   . PHE A 1 277 ? 105.785 102.676 134.831 1.00 75.83  ? 277 PHE A N   1 
ATOM   1636 C  CA  . PHE A 1 277 ? 105.160 101.375 134.613 1.00 67.24  ? 277 PHE A CA  1 
ATOM   1637 C  C   . PHE A 1 277 ? 104.643 100.773 135.914 1.00 67.93  ? 277 PHE A C   1 
ATOM   1638 O  O   . PHE A 1 277 ? 103.546 100.206 135.952 1.00 70.63  ? 277 PHE A O   1 
ATOM   1639 C  CB  . PHE A 1 277 ? 106.157 100.430 133.941 1.00 65.14  ? 277 PHE A CB  1 
ATOM   1640 C  CG  . PHE A 1 277 ? 105.623 99.047  133.706 1.00 69.78  ? 277 PHE A CG  1 
ATOM   1641 C  CD1 . PHE A 1 277 ? 104.727 98.800  132.681 1.00 71.69  ? 277 PHE A CD1 1 
ATOM   1642 C  CD2 . PHE A 1 277 ? 106.026 97.991  134.507 1.00 71.30  ? 277 PHE A CD2 1 
ATOM   1643 C  CE1 . PHE A 1 277 ? 104.238 97.527  132.463 1.00 71.04  ? 277 PHE A CE1 1 
ATOM   1644 C  CE2 . PHE A 1 277 ? 105.540 96.716  134.294 1.00 69.10  ? 277 PHE A CE2 1 
ATOM   1645 C  CZ  . PHE A 1 277 ? 104.645 96.484  133.271 1.00 69.95  ? 277 PHE A CZ  1 
ATOM   1646 N  N   . VAL A 1 278 ? 105.425 100.879 136.991 1.00 71.87  ? 278 VAL A N   1 
ATOM   1647 C  CA  . VAL A 1 278 ? 105.059 100.223 138.245 1.00 72.36  ? 278 VAL A CA  1 
ATOM   1648 C  C   . VAL A 1 278 ? 103.768 100.806 138.804 1.00 77.22  ? 278 VAL A C   1 
ATOM   1649 O  O   . VAL A 1 278 ? 102.921 100.079 139.336 1.00 80.16  ? 278 VAL A O   1 
ATOM   1650 C  CB  . VAL A 1 278 ? 106.213 100.326 139.258 1.00 69.43  ? 278 VAL A CB  1 
ATOM   1651 C  CG1 . VAL A 1 278 ? 105.898 99.515  140.503 1.00 68.17  ? 278 VAL A CG1 1 
ATOM   1652 C  CG2 . VAL A 1 278 ? 107.510 99.852  138.627 1.00 72.51  ? 278 VAL A CG2 1 
ATOM   1653 N  N   . ARG A 1 279 ? 103.598 102.125 138.702 1.00 77.38  ? 279 ARG A N   1 
ATOM   1654 C  CA  . ARG A 1 279 ? 102.389 102.755 139.223 1.00 77.56  ? 279 ARG A CA  1 
ATOM   1655 C  C   . ARG A 1 279 ? 101.158 102.339 138.426 1.00 80.98  ? 279 ARG A C   1 
ATOM   1656 O  O   . ARG A 1 279 ? 100.077 102.154 138.996 1.00 82.87  ? 279 ARG A O   1 
ATOM   1657 C  CB  . ARG A 1 279 ? 102.550 104.275 139.218 1.00 77.00  ? 279 ARG A CB  1 
ATOM   1658 C  CG  . ARG A 1 279 ? 101.300 105.038 139.621 1.00 79.91  ? 279 ARG A CG  1 
ATOM   1659 C  CD  . ARG A 1 279 ? 101.412 105.560 141.043 1.00 82.10  ? 279 ARG A CD  1 
ATOM   1660 N  NE  . ARG A 1 279 ? 100.987 104.569 142.024 1.00 79.41  ? 279 ARG A NE  1 
ATOM   1661 C  CZ  . ARG A 1 279 ? 99.722  104.300 142.315 1.00 80.72  ? 279 ARG A CZ  1 
ATOM   1662 N  NH1 . ARG A 1 279 ? 98.726  104.941 141.728 1.00 83.48  ? 279 ARG A NH1 1 
ATOM   1663 N  NH2 . ARG A 1 279 ? 99.450  103.365 143.221 1.00 81.80  ? 279 ARG A NH2 1 
ATOM   1664 N  N   . GLY A 1 280 ? 101.302 102.184 137.108 1.00 73.58  ? 280 GLY A N   1 
ATOM   1665 C  CA  . GLY A 1 280 ? 100.151 101.865 136.277 1.00 72.28  ? 280 GLY A CA  1 
ATOM   1666 C  C   . GLY A 1 280 ? 99.569  100.495 136.572 1.00 74.28  ? 280 GLY A C   1 
ATOM   1667 O  O   . GLY A 1 280 ? 98.348  100.320 136.606 1.00 81.13  ? 280 GLY A O   1 
ATOM   1668 N  N   . VAL A 1 281 ? 100.436 99.502  136.782 1.00 72.12  ? 281 VAL A N   1 
ATOM   1669 C  CA  . VAL A 1 281 ? 99.979  98.141  137.043 1.00 72.87  ? 281 VAL A CA  1 
ATOM   1670 C  C   . VAL A 1 281 ? 99.204  98.052  138.351 1.00 75.49  ? 281 VAL A C   1 
ATOM   1671 O  O   . VAL A 1 281 ? 98.182  97.361  138.420 1.00 78.64  ? 281 VAL A O   1 
ATOM   1672 C  CB  . VAL A 1 281 ? 101.181 97.172  137.038 1.00 69.81  ? 281 VAL A CB  1 
ATOM   1673 C  CG1 . VAL A 1 281 ? 100.820 95.854  137.702 1.00 73.16  ? 281 VAL A CG1 1 
ATOM   1674 C  CG2 . VAL A 1 281 ? 101.664 96.938  135.618 1.00 70.05  ? 281 VAL A CG2 1 
ATOM   1675 N  N   . THR A 1 282 ? 99.659  98.749  139.389 1.00 75.94  ? 282 THR A N   1 
ATOM   1676 C  CA  . THR A 1 282 ? 99.009  98.748  140.693 1.00 75.95  ? 282 THR A CA  1 
ATOM   1677 C  C   . THR A 1 282 ? 97.589  99.307  140.650 1.00 78.15  ? 282 THR A C   1 
ATOM   1678 O  O   . THR A 1 282 ? 96.755  98.903  141.469 1.00 81.06  ? 282 THR A O   1 
ATOM   1679 C  CB  . THR A 1 282 ? 99.868  99.548  141.688 1.00 79.81  ? 282 THR A CB  1 
ATOM   1680 O  OG1 . THR A 1 282 ? 101.084 98.834  141.946 1.00 81.54  ? 282 THR A OG1 1 
ATOM   1681 C  CG2 . THR A 1 282 ? 99.146  99.767  143.012 1.00 78.36  ? 282 THR A CG2 1 
ATOM   1682 N  N   . LEU A 1 283 ? 97.284  100.179 139.690 1.00 73.25  ? 283 LEU A N   1 
ATOM   1683 C  CA  . LEU A 1 283 ? 95.994  100.850 139.623 1.00 72.56  ? 283 LEU A CA  1 
ATOM   1684 C  C   . LEU A 1 283 ? 94.849  99.844  139.495 1.00 76.41  ? 283 LEU A C   1 
ATOM   1685 O  O   . LEU A 1 283 ? 95.042  98.664  139.189 1.00 78.14  ? 283 LEU A O   1 
ATOM   1686 C  CB  . LEU A 1 283 ? 95.961  101.823 138.445 1.00 71.30  ? 283 LEU A CB  1 
ATOM   1687 C  CG  . LEU A 1 283 ? 96.839  103.068 138.546 1.00 74.87  ? 283 LEU A CG  1 
ATOM   1688 C  CD1 . LEU A 1 283 ? 96.881  103.797 137.213 1.00 74.11  ? 283 LEU A CD1 1 
ATOM   1689 C  CD2 . LEU A 1 283 ? 96.322  103.982 139.640 1.00 75.83  ? 283 LEU A CD2 1 
ATOM   1690 N  N   . GLU A 1 284 ? 93.637  100.338 139.733 1.00 81.83  ? 284 GLU A N   1 
ATOM   1691 C  CA  . GLU A 1 284 ? 92.427  99.530  139.643 1.00 82.02  ? 284 GLU A CA  1 
ATOM   1692 C  C   . GLU A 1 284 ? 91.846  99.653  138.239 1.00 81.83  ? 284 GLU A C   1 
ATOM   1693 O  O   . GLU A 1 284 ? 91.624  100.764 137.748 1.00 81.93  ? 284 GLU A O   1 
ATOM   1694 C  CB  . GLU A 1 284 ? 91.408  99.973  140.691 1.00 79.97  ? 284 GLU A CB  1 
ATOM   1695 C  CG  . GLU A 1 284 ? 89.963  99.677  140.326 1.00 81.98  ? 284 GLU A CG  1 
ATOM   1696 C  CD  . GLU A 1 284 ? 89.469  98.369  140.906 1.00 87.09  ? 284 GLU A CD  1 
ATOM   1697 O  OE1 . GLU A 1 284 ? 90.297  97.457  141.113 1.00 87.66  ? 284 GLU A OE1 1 
ATOM   1698 O  OE2 . GLU A 1 284 ? 88.251  98.251  141.155 1.00 87.16  ? 284 GLU A OE2 1 
ATOM   1699 N  N   . GLY A 1 285 ? 91.600  98.513  137.599 1.00 73.95  ? 285 GLY A N   1 
ATOM   1700 C  CA  . GLY A 1 285 ? 91.088  98.489  136.247 1.00 72.33  ? 285 GLY A CA  1 
ATOM   1701 C  C   . GLY A 1 285 ? 92.137  98.431  135.159 1.00 74.19  ? 285 GLY A C   1 
ATOM   1702 O  O   . GLY A 1 285 ? 91.775  98.429  133.976 1.00 77.25  ? 285 GLY A O   1 
ATOM   1703 N  N   . ALA A 1 286 ? 93.424  98.387  135.515 1.00 63.65  ? 286 ALA A N   1 
ATOM   1704 C  CA  . ALA A 1 286 ? 94.470  98.310  134.501 1.00 65.77  ? 286 ALA A CA  1 
ATOM   1705 C  C   . ALA A 1 286 ? 94.506  96.944  133.828 1.00 72.73  ? 286 ALA A C   1 
ATOM   1706 O  O   . ALA A 1 286 ? 94.960  96.829  132.682 1.00 77.18  ? 286 ALA A O   1 
ATOM   1707 C  CB  . ALA A 1 286 ? 95.828  98.627  135.125 1.00 61.77  ? 286 ALA A CB  1 
ATOM   1708 N  N   . PHE A 1 287 ? 94.038  95.903  134.522 1.00 77.04  ? 287 PHE A N   1 
ATOM   1709 C  CA  . PHE A 1 287 ? 94.046  94.562  133.948 1.00 69.06  ? 287 PHE A CA  1 
ATOM   1710 C  C   . PHE A 1 287 ? 93.158  94.486  132.713 1.00 70.94  ? 287 PHE A C   1 
ATOM   1711 O  O   . PHE A 1 287 ? 93.518  93.842  131.722 1.00 74.53  ? 287 PHE A O   1 
ATOM   1712 C  CB  . PHE A 1 287 ? 93.603  93.544  134.999 1.00 70.71  ? 287 PHE A CB  1 
ATOM   1713 C  CG  . PHE A 1 287 ? 93.546  92.132  134.492 1.00 78.85  ? 287 PHE A CG  1 
ATOM   1714 C  CD1 . PHE A 1 287 ? 92.332  91.535  134.195 1.00 77.88  ? 287 PHE A CD1 1 
ATOM   1715 C  CD2 . PHE A 1 287 ? 94.707  91.399  134.313 1.00 78.59  ? 287 PHE A CD2 1 
ATOM   1716 C  CE1 . PHE A 1 287 ? 92.278  90.236  133.728 1.00 75.50  ? 287 PHE A CE1 1 
ATOM   1717 C  CE2 . PHE A 1 287 ? 94.659  90.099  133.847 1.00 76.34  ? 287 PHE A CE2 1 
ATOM   1718 C  CZ  . PHE A 1 287 ? 93.443  89.518  133.554 1.00 74.86  ? 287 PHE A CZ  1 
ATOM   1719 N  N   . ASP A 1 288 ? 91.990  95.134  132.755 1.00 65.10  ? 288 ASP A N   1 
ATOM   1720 C  CA  . ASP A 1 288 ? 91.116  95.159  131.588 1.00 65.69  ? 288 ASP A CA  1 
ATOM   1721 C  C   . ASP A 1 288 ? 91.769  95.870  130.411 1.00 69.46  ? 288 ASP A C   1 
ATOM   1722 O  O   . ASP A 1 288 ? 91.642  95.416  129.267 1.00 76.22  ? 288 ASP A O   1 
ATOM   1723 C  CB  . ASP A 1 288 ? 89.786  95.824  131.937 1.00 66.07  ? 288 ASP A CB  1 
ATOM   1724 C  CG  . ASP A 1 288 ? 89.068  95.125  133.071 1.00 75.47  ? 288 ASP A CG  1 
ATOM   1725 O  OD1 . ASP A 1 288 ? 89.064  93.877  133.090 1.00 77.88  ? 288 ASP A OD1 1 
ATOM   1726 O  OD2 . ASP A 1 288 ? 88.505  95.821  133.942 1.00 80.47  ? 288 ASP A OD2 1 
ATOM   1727 N  N   . GLY A 1 289 ? 92.466  96.974  130.665 1.00 55.70  ? 289 GLY A N   1 
ATOM   1728 C  CA  . GLY A 1 289 ? 93.199  97.661  129.622 1.00 48.85  ? 289 GLY A CA  1 
ATOM   1729 C  C   . GLY A 1 289 ? 94.277  96.793  129.008 1.00 52.01  ? 289 GLY A C   1 
ATOM   1730 O  O   . GLY A 1 289 ? 94.432  96.759  127.785 1.00 64.32  ? 289 GLY A O   1 
ATOM   1731 N  N   . ILE A 1 290 ? 95.018  96.067  129.848 1.00 51.38  ? 290 ILE A N   1 
ATOM   1732 C  CA  . ILE A 1 290 ? 96.061  95.182  129.335 1.00 60.64  ? 290 ILE A CA  1 
ATOM   1733 C  C   . ILE A 1 290 ? 95.454  94.059  128.498 1.00 63.28  ? 290 ILE A C   1 
ATOM   1734 O  O   . ILE A 1 290 ? 95.977  93.709  127.431 1.00 60.97  ? 290 ILE A O   1 
ATOM   1735 C  CB  . ILE A 1 290 ? 96.915  94.634  130.492 1.00 58.24  ? 290 ILE A CB  1 
ATOM   1736 C  CG1 . ILE A 1 290 ? 97.772  95.749  131.092 1.00 52.55  ? 290 ILE A CG1 1 
ATOM   1737 C  CG2 . ILE A 1 290 ? 97.798  93.492  130.015 1.00 54.54  ? 290 ILE A CG2 1 
ATOM   1738 C  CD1 . ILE A 1 290 ? 98.197  95.489  132.514 1.00 55.27  ? 290 ILE A CD1 1 
ATOM   1739 N  N   . MET A 1 291 ? 94.348  93.472  128.966 1.00 55.00  ? 291 MET A N   1 
ATOM   1740 C  CA  . MET A 1 291 ? 93.692  92.414  128.202 1.00 50.31  ? 291 MET A CA  1 
ATOM   1741 C  C   . MET A 1 291 ? 93.195  92.928  126.858 1.00 52.74  ? 291 MET A C   1 
ATOM   1742 O  O   . MET A 1 291 ? 93.334  92.247  125.836 1.00 58.69  ? 291 MET A O   1 
ATOM   1743 C  CB  . MET A 1 291 ? 92.538  91.814  129.004 1.00 58.81  ? 291 MET A CB  1 
ATOM   1744 C  CG  . MET A 1 291 ? 92.959  91.115  130.284 1.00 65.81  ? 291 MET A CG  1 
ATOM   1745 S  SD  . MET A 1 291 ? 94.341  89.984  130.045 1.00 79.46  ? 291 MET A SD  1 
ATOM   1746 C  CE  . MET A 1 291 ? 93.518  88.615  129.237 1.00 63.79  ? 291 MET A CE  1 
ATOM   1747 N  N   . TYR A 1 292 ? 92.607  94.126  126.837 1.00 53.33  ? 292 TYR A N   1 
ATOM   1748 C  CA  . TYR A 1 292 ? 92.194  94.724  125.572 1.00 53.14  ? 292 TYR A CA  1 
ATOM   1749 C  C   . TYR A 1 292 ? 93.397  94.980  124.672 1.00 54.68  ? 292 TYR A C   1 
ATOM   1750 O  O   . TYR A 1 292 ? 93.299  94.878  123.444 1.00 57.43  ? 292 TYR A O   1 
ATOM   1751 C  CB  . TYR A 1 292 ? 91.430  96.021  125.839 1.00 50.13  ? 292 TYR A CB  1 
ATOM   1752 C  CG  . TYR A 1 292 ? 90.915  96.717  124.600 1.00 54.50  ? 292 TYR A CG  1 
ATOM   1753 C  CD1 . TYR A 1 292 ? 89.812  96.230  123.917 1.00 55.69  ? 292 TYR A CD1 1 
ATOM   1754 C  CD2 . TYR A 1 292 ? 91.525  97.869  124.123 1.00 50.01  ? 292 TYR A CD2 1 
ATOM   1755 C  CE1 . TYR A 1 292 ? 89.335  96.864  122.789 1.00 58.01  ? 292 TYR A CE1 1 
ATOM   1756 C  CE2 . TYR A 1 292 ? 91.055  98.510  122.996 1.00 47.07  ? 292 TYR A CE2 1 
ATOM   1757 C  CZ  . TYR A 1 292 ? 89.960  98.003  122.333 1.00 55.98  ? 292 TYR A CZ  1 
ATOM   1758 O  OH  . TYR A 1 292 ? 89.485  98.636  121.209 1.00 56.84  ? 292 TYR A OH  1 
ATOM   1759 N  N   . TYR A 1 293 ? 94.541  95.310  125.271 1.00 46.58  ? 293 TYR A N   1 
ATOM   1760 C  CA  . TYR A 1 293 ? 95.759  95.545  124.505 1.00 44.71  ? 293 TYR A CA  1 
ATOM   1761 C  C   . TYR A 1 293 ? 96.301  94.263  123.884 1.00 53.34  ? 293 TYR A C   1 
ATOM   1762 O  O   . TYR A 1 293 ? 96.849  94.298  122.776 1.00 58.09  ? 293 TYR A O   1 
ATOM   1763 C  CB  . TYR A 1 293 ? 96.808  96.189  125.412 1.00 46.87  ? 293 TYR A CB  1 
ATOM   1764 C  CG  . TYR A 1 293 ? 98.150  96.452  124.770 1.00 47.47  ? 293 TYR A CG  1 
ATOM   1765 C  CD1 . TYR A 1 293 ? 98.248  97.111  123.554 1.00 45.22  ? 293 TYR A CD1 1 
ATOM   1766 C  CD2 . TYR A 1 293 ? 99.324  96.059  125.397 1.00 49.10  ? 293 TYR A CD2 1 
ATOM   1767 C  CE1 . TYR A 1 293 ? 99.476  97.360  122.975 1.00 48.03  ? 293 TYR A CE1 1 
ATOM   1768 C  CE2 . TYR A 1 293 ? 100.555 96.302  124.826 1.00 47.34  ? 293 TYR A CE2 1 
ATOM   1769 C  CZ  . TYR A 1 293 ? 100.626 96.952  123.616 1.00 48.75  ? 293 TYR A CZ  1 
ATOM   1770 O  OH  . TYR A 1 293 ? 101.853 97.194  123.048 1.00 53.18  ? 293 TYR A OH  1 
ATOM   1771 N  N   . LEU A 1 294 ? 96.162  93.128  124.568 1.00 60.60  ? 294 LEU A N   1 
ATOM   1772 C  CA  . LEU A 1 294 ? 96.807  91.890  124.141 1.00 56.21  ? 294 LEU A CA  1 
ATOM   1773 C  C   . LEU A 1 294 ? 95.881  90.928  123.407 1.00 54.65  ? 294 LEU A C   1 
ATOM   1774 O  O   . LEU A 1 294 ? 96.347  90.173  122.549 1.00 61.76  ? 294 LEU A O   1 
ATOM   1775 C  CB  . LEU A 1 294 ? 97.421  91.174  125.349 1.00 59.71  ? 294 LEU A CB  1 
ATOM   1776 C  CG  . LEU A 1 294 ? 98.757  91.717  125.862 1.00 60.09  ? 294 LEU A CG  1 
ATOM   1777 C  CD1 . LEU A 1 294 ? 99.463  90.678  126.713 1.00 55.34  ? 294 LEU A CD1 1 
ATOM   1778 C  CD2 . LEU A 1 294 ? 99.646  92.156  124.709 1.00 54.90  ? 294 LEU A CD2 1 
ATOM   1779 N  N   . THR A 1 295 ? 94.589  90.923  123.719 1.00 58.02  ? 295 THR A N   1 
ATOM   1780 C  CA  . THR A 1 295 ? 93.686  89.941  123.130 1.00 53.93  ? 295 THR A CA  1 
ATOM   1781 C  C   . THR A 1 295 ? 93.496  90.216  121.641 1.00 63.05  ? 295 THR A C   1 
ATOM   1782 O  O   . THR A 1 295 ? 93.150  91.343  121.262 1.00 67.36  ? 295 THR A O   1 
ATOM   1783 C  CB  . THR A 1 295 ? 92.334  89.958  123.841 1.00 60.59  ? 295 THR A CB  1 
ATOM   1784 O  OG1 . THR A 1 295 ? 92.468  89.360  125.136 1.00 66.41  ? 295 THR A OG1 1 
ATOM   1785 C  CG2 . THR A 1 295 ? 91.298  89.186  123.041 1.00 58.07  ? 295 THR A CG2 1 
ATOM   1786 N  N   . PRO A 1 296 ? 93.702  89.226  120.771 1.00 73.20  ? 296 PRO A N   1 
ATOM   1787 C  CA  . PRO A 1 296 ? 93.548  89.448  119.330 1.00 69.39  ? 296 PRO A CA  1 
ATOM   1788 C  C   . PRO A 1 296 ? 92.125  89.224  118.844 1.00 70.92  ? 296 PRO A C   1 
ATOM   1789 O  O   . PRO A 1 296 ? 91.408  88.333  119.306 1.00 74.39  ? 296 PRO A O   1 
ATOM   1790 C  CB  . PRO A 1 296 ? 94.498  88.401  118.722 1.00 64.88  ? 296 PRO A CB  1 
ATOM   1791 C  CG  . PRO A 1 296 ? 95.149  87.687  119.923 1.00 68.12  ? 296 PRO A CG  1 
ATOM   1792 C  CD  . PRO A 1 296 ? 94.172  87.860  121.029 1.00 71.38  ? 296 PRO A CD  1 
ATOM   1793 N  N   . GLN A 1 297 ? 91.717  90.054  117.888 1.00 71.29  ? 297 GLN A N   1 
ATOM   1794 C  CA  . GLN A 1 297 ? 90.425  89.932  117.225 1.00 67.37  ? 297 GLN A CA  1 
ATOM   1795 C  C   . GLN A 1 297 ? 90.664  89.451  115.801 1.00 72.85  ? 297 GLN A C   1 
ATOM   1796 O  O   . GLN A 1 297 ? 91.414  90.082  115.048 1.00 74.86  ? 297 GLN A O   1 
ATOM   1797 C  CB  . GLN A 1 297 ? 89.674  91.263  117.228 1.00 68.27  ? 297 GLN A CB  1 
ATOM   1798 C  CG  . GLN A 1 297 ? 89.287  91.754  118.612 1.00 71.78  ? 297 GLN A CG  1 
ATOM   1799 C  CD  . GLN A 1 297 ? 89.506  93.244  118.783 1.00 76.98  ? 297 GLN A CD  1 
ATOM   1800 O  OE1 . GLN A 1 297 ? 89.012  94.048  117.994 1.00 72.39  ? 297 GLN A OE1 1 
ATOM   1801 N  NE2 . GLN A 1 297 ? 90.248  93.619  119.818 1.00 74.33  ? 297 GLN A NE2 1 
ATOM   1802 N  N   . TRP A 1 298 ? 90.029  88.341  115.434 1.00 74.68  ? 298 TRP A N   1 
ATOM   1803 C  CA  . TRP A 1 298 ? 90.264  87.710  114.142 1.00 71.26  ? 298 TRP A CA  1 
ATOM   1804 C  C   . TRP A 1 298 ? 89.309  88.191  113.058 1.00 72.96  ? 298 TRP A C   1 
ATOM   1805 O  O   . TRP A 1 298 ? 89.453  87.780  111.903 1.00 76.31  ? 298 TRP A O   1 
ATOM   1806 C  CB  . TRP A 1 298 ? 90.164  86.187  114.278 1.00 68.84  ? 298 TRP A CB  1 
ATOM   1807 C  CG  . TRP A 1 298 ? 91.242  85.581  115.132 1.00 73.70  ? 298 TRP A CG  1 
ATOM   1808 C  CD1 . TRP A 1 298 ? 91.067  84.816  116.247 1.00 75.75  ? 298 TRP A CD1 1 
ATOM   1809 C  CD2 . TRP A 1 298 ? 92.659  85.690  114.940 1.00 71.84  ? 298 TRP A CD2 1 
ATOM   1810 N  NE1 . TRP A 1 298 ? 92.284  84.443  116.763 1.00 73.95  ? 298 TRP A NE1 1 
ATOM   1811 C  CE2 . TRP A 1 298 ? 93.277  84.967  115.979 1.00 72.04  ? 298 TRP A CE2 1 
ATOM   1812 C  CE3 . TRP A 1 298 ? 93.464  86.329  113.993 1.00 71.33  ? 298 TRP A CE3 1 
ATOM   1813 C  CZ2 . TRP A 1 298 ? 94.659  84.865  116.096 1.00 71.29  ? 298 TRP A CZ2 1 
ATOM   1814 C  CZ3 . TRP A 1 298 ? 94.836  86.227  114.113 1.00 68.64  ? 298 TRP A CZ3 1 
ATOM   1815 C  CH2 . TRP A 1 298 ? 95.419  85.500  115.155 1.00 71.20  ? 298 TRP A CH2 1 
ATOM   1816 N  N   . ASP A 1 299 ? 88.346  89.048  113.395 1.00 81.37  ? 299 ASP A N   1 
ATOM   1817 C  CA  . ASP A 1 299 ? 87.396  89.566  112.419 1.00 78.70  ? 299 ASP A CA  1 
ATOM   1818 C  C   . ASP A 1 299 ? 87.972  90.701  111.585 1.00 78.87  ? 299 ASP A C   1 
ATOM   1819 O  O   . ASP A 1 299 ? 87.727  90.747  110.375 1.00 78.07  ? 299 ASP A O   1 
ATOM   1820 C  CB  . ASP A 1 299 ? 86.120  90.041  113.135 1.00 81.28  ? 299 ASP A CB  1 
ATOM   1821 C  CG  . ASP A 1 299 ? 84.964  90.346  112.179 1.00 88.52  ? 299 ASP A CG  1 
ATOM   1822 O  OD1 . ASP A 1 299 ? 85.177  90.926  111.095 1.00 86.57  ? 299 ASP A OD1 1 
ATOM   1823 O  OD2 . ASP A 1 299 ? 83.819  89.986  112.523 1.00 89.59  ? 299 ASP A OD2 1 
ATOM   1824 N  N   . LYS A 1 300 ? 88.756  91.590  112.190 1.00 75.80  ? 300 LYS A N   1 
ATOM   1825 C  CA  . LYS A 1 300 ? 89.298  92.754  111.506 1.00 74.89  ? 300 LYS A CA  1 
ATOM   1826 C  C   . LYS A 1 300 ? 90.571  92.442  110.733 1.00 77.67  ? 300 LYS A C   1 
ATOM   1827 O  O   . LYS A 1 300 ? 91.126  93.338  110.088 1.00 78.24  ? 300 LYS A O   1 
ATOM   1828 C  CB  . LYS A 1 300 ? 89.561  93.879  112.509 1.00 77.19  ? 300 LYS A CB  1 
ATOM   1829 C  CG  . LYS A 1 300 ? 88.401  94.845  112.674 1.00 79.03  ? 300 LYS A CG  1 
ATOM   1830 C  CD  . LYS A 1 300 ? 88.408  95.503  114.044 1.00 81.26  ? 300 LYS A CD  1 
ATOM   1831 C  CE  . LYS A 1 300 ? 88.541  97.012  113.922 1.00 79.53  ? 300 LYS A CE  1 
ATOM   1832 N  NZ  . LYS A 1 300 ? 87.739  97.712  114.959 1.00 80.32  ? 300 LYS A NZ  1 
ATOM   1833 N  N   . ILE A 1 301 ? 91.051  91.199  110.785 1.00 73.15  ? 301 ILE A N   1 
ATOM   1834 C  CA  . ILE A 1 301 ? 92.262  90.832  110.059 1.00 72.22  ? 301 ILE A CA  1 
ATOM   1835 C  C   . ILE A 1 301 ? 92.062  90.807  108.547 1.00 70.35  ? 301 ILE A C   1 
ATOM   1836 O  O   . ILE A 1 301 ? 93.026  91.039  107.804 1.00 69.31  ? 301 ILE A O   1 
ATOM   1837 C  CB  . ILE A 1 301 ? 92.809  89.481  110.556 1.00 72.77  ? 301 ILE A CB  1 
ATOM   1838 C  CG1 . ILE A 1 301 ? 94.335  89.479  110.491 1.00 71.51  ? 301 ILE A CG1 1 
ATOM   1839 C  CG2 . ILE A 1 301 ? 92.239  88.317  109.761 1.00 70.24  ? 301 ILE A CG2 1 
ATOM   1840 C  CD1 . ILE A 1 301 ? 94.973  88.519  111.449 1.00 74.00  ? 301 ILE A CD1 1 
ATOM   1841 N  N   . LEU A 1 302 ? 90.853  90.521  108.069 1.00 72.63  ? 302 LEU A N   1 
ATOM   1842 C  CA  . LEU A 1 302 ? 90.559  90.523  106.637 1.00 69.42  ? 302 LEU A CA  1 
ATOM   1843 C  C   . LEU A 1 302 ? 90.213  91.911  106.121 1.00 69.37  ? 302 LEU A C   1 
ATOM   1844 O  O   . LEU A 1 302 ? 89.178  92.106  105.477 1.00 74.04  ? 302 LEU A O   1 
ATOM   1845 C  CB  . LEU A 1 302 ? 89.433  89.538  106.344 1.00 69.71  ? 302 LEU A CB  1 
ATOM   1846 C  CG  . LEU A 1 302 ? 89.649  88.125  106.886 1.00 72.18  ? 302 LEU A CG  1 
ATOM   1847 C  CD1 . LEU A 1 302 ? 88.324  87.490  107.271 1.00 72.79  ? 302 LEU A CD1 1 
ATOM   1848 C  CD2 . LEU A 1 302 ? 90.380  87.271  105.862 1.00 69.35  ? 302 LEU A CD2 1 
ATOM   1849 N  N   . GLU A 1 303 ? 91.065  92.894  106.390 1.00 66.13  ? 303 GLU A N   1 
ATOM   1850 C  CA  . GLU A 1 303 ? 90.876  94.260  105.928 1.00 62.99  ? 303 GLU A CA  1 
ATOM   1851 C  C   . GLU A 1 303 ? 92.232  94.854  105.585 1.00 65.78  ? 303 GLU A C   1 
ATOM   1852 O  O   . GLU A 1 303 ? 93.193  94.704  106.344 1.00 66.77  ? 303 GLU A O   1 
ATOM   1853 C  CB  . GLU A 1 303 ? 90.176  95.116  106.988 1.00 65.08  ? 303 GLU A CB  1 
ATOM   1854 C  CG  . GLU A 1 303 ? 88.671  95.205  106.820 1.00 73.05  ? 303 GLU A CG  1 
ATOM   1855 C  CD  . GLU A 1 303 ? 87.973  95.706  108.069 1.00 79.24  ? 303 GLU A CD  1 
ATOM   1856 O  OE1 . GLU A 1 303 ? 86.844  95.248  108.344 1.00 78.25  ? 303 GLU A OE1 1 
ATOM   1857 O  OE2 . GLU A 1 303 ? 88.555  96.551  108.781 1.00 79.32  ? 303 GLU A OE2 1 
ATOM   1858 N  N   . ALA A 1 304 ? 92.304  95.530  104.444 1.00 62.71  ? 304 ALA A N   1 
ATOM   1859 C  CA  . ALA A 1 304 ? 93.553  96.107  103.973 1.00 61.52  ? 304 ALA A CA  1 
ATOM   1860 C  C   . ALA A 1 304 ? 93.935  97.382  104.711 1.00 59.35  ? 304 ALA A C   1 
ATOM   1861 O  O   . ALA A 1 304 ? 95.065  97.853  104.558 1.00 65.42  ? 304 ALA A O   1 
ATOM   1862 C  CB  . ALA A 1 304 ? 93.468  96.387  102.470 1.00 60.89  ? 304 ALA A CB  1 
ATOM   1863 N  N   . LYS A 1 305 ? 93.024  97.951  105.503 1.00 61.88  ? 305 LYS A N   1 
ATOM   1864 C  CA  . LYS A 1 305 ? 93.325  99.199  106.197 1.00 62.66  ? 305 LYS A CA  1 
ATOM   1865 C  C   . LYS A 1 305 ? 94.267  98.975  107.374 1.00 64.38  ? 305 LYS A C   1 
ATOM   1866 O  O   . LYS A 1 305 ? 95.199  99.759  107.586 1.00 64.50  ? 305 LYS A O   1 
ATOM   1867 C  CB  . LYS A 1 305 ? 92.032  99.864  106.663 1.00 60.63  ? 305 LYS A CB  1 
ATOM   1868 C  CG  . LYS A 1 305 ? 92.198  101.325 107.039 1.00 69.78  ? 305 LYS A CG  1 
ATOM   1869 C  CD  . LYS A 1 305 ? 90.863  102.047 107.068 1.00 70.56  ? 305 LYS A CD  1 
ATOM   1870 C  CE  . LYS A 1 305 ? 91.003  103.435 107.670 1.00 72.36  ? 305 LYS A CE  1 
ATOM   1871 N  NZ  . LYS A 1 305 ? 92.430  103.828 107.839 1.00 64.26  ? 305 LYS A NZ  1 
ATOM   1872 N  N   . VAL A 1 306 ? 94.038  97.918  108.156 1.00 58.00  ? 306 VAL A N   1 
ATOM   1873 C  CA  . VAL A 1 306 ? 94.877  97.665  109.324 1.00 47.20  ? 306 VAL A CA  1 
ATOM   1874 C  C   . VAL A 1 306 ? 96.274  97.220  108.902 1.00 55.56  ? 306 VAL A C   1 
ATOM   1875 O  O   . VAL A 1 306 ? 97.273  97.591  109.531 1.00 59.32  ? 306 VAL A O   1 
ATOM   1876 C  CB  . VAL A 1 306 ? 94.197  96.647  110.261 1.00 44.10  ? 306 VAL A CB  1 
ATOM   1877 C  CG1 . VAL A 1 306 ? 94.022  95.300  109.578 1.00 54.37  ? 306 VAL A CG1 1 
ATOM   1878 C  CG2 . VAL A 1 306 ? 94.985  96.499  111.550 1.00 49.63  ? 306 VAL A CG2 1 
ATOM   1879 N  N   . TRP A 1 307 ? 96.370  96.423  107.834 1.00 47.42  ? 307 TRP A N   1 
ATOM   1880 C  CA  . TRP A 1 307 ? 97.674  95.978  107.354 1.00 43.14  ? 307 TRP A CA  1 
ATOM   1881 C  C   . TRP A 1 307 ? 98.499  97.150  106.836 1.00 49.27  ? 307 TRP A C   1 
ATOM   1882 O  O   . TRP A 1 307 ? 99.710  97.227  107.083 1.00 53.70  ? 307 TRP A O   1 
ATOM   1883 C  CB  . TRP A 1 307 ? 97.494  94.920  106.267 1.00 40.22  ? 307 TRP A CB  1 
ATOM   1884 C  CG  . TRP A 1 307 ? 97.065  93.587  106.797 1.00 41.45  ? 307 TRP A CG  1 
ATOM   1885 C  CD1 . TRP A 1 307 ? 95.787  93.137  106.942 1.00 34.51  ? 307 TRP A CD1 1 
ATOM   1886 C  CD2 . TRP A 1 307 ? 97.916  92.527  107.249 1.00 49.10  ? 307 TRP A CD2 1 
ATOM   1887 N  NE1 . TRP A 1 307 ? 95.787  91.865  107.458 1.00 37.74  ? 307 TRP A NE1 1 
ATOM   1888 C  CE2 . TRP A 1 307 ? 97.083  91.467  107.656 1.00 42.98  ? 307 TRP A CE2 1 
ATOM   1889 C  CE3 . TRP A 1 307 ? 99.302  92.372  107.350 1.00 41.20  ? 307 TRP A CE3 1 
ATOM   1890 C  CZ2 . TRP A 1 307 ? 97.588  90.271  108.155 1.00 35.87  ? 307 TRP A CZ2 1 
ATOM   1891 C  CZ3 . TRP A 1 307 ? 99.801  91.183  107.847 1.00 40.75  ? 307 TRP A CZ3 1 
ATOM   1892 C  CH2 . TRP A 1 307 ? 98.946  90.148  108.242 1.00 38.86  ? 307 TRP A CH2 1 
ATOM   1893 N  N   . GLY A 1 308 ? 97.859  98.075  106.118 1.00 42.16  ? 308 GLY A N   1 
ATOM   1894 C  CA  . GLY A 1 308 ? 98.565  99.257  105.656 1.00 43.62  ? 308 GLY A CA  1 
ATOM   1895 C  C   . GLY A 1 308 ? 99.030  100.139 106.798 1.00 42.57  ? 308 GLY A C   1 
ATOM   1896 O  O   . GLY A 1 308 ? 100.134 100.685 106.763 1.00 50.45  ? 308 GLY A O   1 
ATOM   1897 N  N   . ASP A 1 309 ? 98.196  100.284 107.829 1.00 41.39  ? 309 ASP A N   1 
ATOM   1898 C  CA  . ASP A 1 309 ? 98.595  101.048 109.007 1.00 40.78  ? 309 ASP A CA  1 
ATOM   1899 C  C   . ASP A 1 309 ? 99.783  100.402 109.709 1.00 46.45  ? 309 ASP A C   1 
ATOM   1900 O  O   . ASP A 1 309 ? 100.713 101.095 110.138 1.00 51.68  ? 309 ASP A O   1 
ATOM   1901 C  CB  . ASP A 1 309 ? 97.414  101.180 109.968 1.00 46.45  ? 309 ASP A CB  1 
ATOM   1902 C  CG  . ASP A 1 309 ? 96.567  102.402 109.683 1.00 64.64  ? 309 ASP A CG  1 
ATOM   1903 O  OD1 . ASP A 1 309 ? 96.286  102.669 108.497 1.00 67.20  ? 309 ASP A OD1 1 
ATOM   1904 O  OD2 . ASP A 1 309 ? 96.178  103.094 110.646 1.00 70.71  ? 309 ASP A OD2 1 
ATOM   1905 N  N   . ALA A 1 310 ? 99.765  99.073  109.844 1.00 42.91  ? 310 ALA A N   1 
ATOM   1906 C  CA  . ALA A 1 310 ? 100.881 98.380  110.481 1.00 37.50  ? 310 ALA A CA  1 
ATOM   1907 C  C   . ALA A 1 310 ? 102.166 98.543  109.679 1.00 41.17  ? 310 ALA A C   1 
ATOM   1908 O  O   . ALA A 1 310 ? 103.237 98.789  110.250 1.00 49.85  ? 310 ALA A O   1 
ATOM   1909 C  CB  . ALA A 1 310 ? 100.543 96.901  110.661 1.00 37.04  ? 310 ALA A CB  1 
ATOM   1910 N  N   . ALA A 1 311 ? 102.080 98.412  108.352 1.00 37.82  ? 311 ALA A N   1 
ATOM   1911 C  CA  . ALA A 1 311 ? 103.262 98.600  107.516 1.00 33.88  ? 311 ALA A CA  1 
ATOM   1912 C  C   . ALA A 1 311 ? 103.787 100.027 107.615 1.00 42.78  ? 311 ALA A C   1 
ATOM   1913 O  O   . ALA A 1 311 ? 105.003 100.247 107.693 1.00 43.28  ? 311 ALA A O   1 
ATOM   1914 C  CB  . ALA A 1 311 ? 102.939 98.245  106.066 1.00 36.48  ? 311 ALA A CB  1 
ATOM   1915 N  N   . SER A 1 312 ? 102.882 101.009 107.618 1.00 40.32  ? 312 SER A N   1 
ATOM   1916 C  CA  . SER A 1 312 ? 103.290 102.402 107.754 1.00 33.21  ? 312 SER A CA  1 
ATOM   1917 C  C   . SER A 1 312 ? 103.995 102.645 109.079 1.00 35.65  ? 312 SER A C   1 
ATOM   1918 O  O   . SER A 1 312 ? 105.032 103.315 109.122 1.00 42.31  ? 312 SER A O   1 
ATOM   1919 C  CB  . SER A 1 312 ? 102.073 103.315 107.623 1.00 44.60  ? 312 SER A CB  1 
ATOM   1920 O  OG  . SER A 1 312 ? 101.169 102.817 106.654 1.00 55.10  ? 312 SER A OG  1 
ATOM   1921 N  N   . GLN A 1 313 ? 103.451 102.106 110.172 1.00 32.62  ? 313 GLN A N   1 
ATOM   1922 C  CA  . GLN A 1 313 ? 104.081 102.288 111.475 1.00 33.63  ? 313 GLN A CA  1 
ATOM   1923 C  C   . GLN A 1 313 ? 105.453 101.627 111.525 1.00 37.84  ? 313 GLN A C   1 
ATOM   1924 O  O   . GLN A 1 313 ? 106.407 102.199 112.066 1.00 39.82  ? 313 GLN A O   1 
ATOM   1925 C  CB  . GLN A 1 313 ? 103.177 101.738 112.577 1.00 41.47  ? 313 GLN A CB  1 
ATOM   1926 C  CG  . GLN A 1 313 ? 103.726 101.919 113.982 1.00 45.88  ? 313 GLN A CG  1 
ATOM   1927 C  CD  . GLN A 1 313 ? 103.919 103.376 114.350 1.00 46.23  ? 313 GLN A CD  1 
ATOM   1928 O  OE1 . GLN A 1 313 ? 103.051 104.209 114.103 1.00 50.40  ? 313 GLN A OE1 1 
ATOM   1929 N  NE2 . GLN A 1 313 ? 105.063 103.690 114.942 1.00 42.77  ? 313 GLN A NE2 1 
ATOM   1930 N  N   . ILE A 1 314 ? 105.574 100.424 110.957 1.00 37.97  ? 314 ILE A N   1 
ATOM   1931 C  CA  . ILE A 1 314 ? 106.855 99.721  110.977 1.00 36.30  ? 314 ILE A CA  1 
ATOM   1932 C  C   . ILE A 1 314 ? 107.903 100.488 110.181 1.00 36.08  ? 314 ILE A C   1 
ATOM   1933 O  O   . ILE A 1 314 ? 109.051 100.631 110.618 1.00 41.99  ? 314 ILE A O   1 
ATOM   1934 C  CB  . ILE A 1 314 ? 106.685 98.282  110.455 1.00 45.01  ? 314 ILE A CB  1 
ATOM   1935 C  CG1 . ILE A 1 314 ? 105.941 97.433  111.484 1.00 40.55  ? 314 ILE A CG1 1 
ATOM   1936 C  CG2 . ILE A 1 314 ? 108.035 97.664  110.129 1.00 42.88  ? 314 ILE A CG2 1 
ATOM   1937 C  CD1 . ILE A 1 314 ? 106.820 96.914  112.590 1.00 39.36  ? 314 ILE A CD1 1 
ATOM   1938 N  N   . PHE A 1 315 ? 107.530 101.000 109.006 1.00 44.13  ? 315 PHE A N   1 
ATOM   1939 C  CA  . PHE A 1 315 ? 108.506 101.707 108.183 1.00 34.11  ? 315 PHE A CA  1 
ATOM   1940 C  C   . PHE A 1 315 ? 108.818 103.094 108.733 1.00 45.64  ? 315 PHE A C   1 
ATOM   1941 O  O   . PHE A 1 315 ? 109.926 103.602 108.531 1.00 49.17  ? 315 PHE A O   1 
ATOM   1942 C  CB  . PHE A 1 315 ? 108.009 101.799 106.741 1.00 25.94  ? 315 PHE A CB  1 
ATOM   1943 C  CG  . PHE A 1 315 ? 108.289 100.567 105.930 1.00 43.77  ? 315 PHE A CG  1 
ATOM   1944 C  CD1 . PHE A 1 315 ? 107.725 99.350  106.276 1.00 46.43  ? 315 PHE A CD1 1 
ATOM   1945 C  CD2 . PHE A 1 315 ? 109.120 100.621 104.828 1.00 43.85  ? 315 PHE A CD2 1 
ATOM   1946 C  CE1 . PHE A 1 315 ? 107.981 98.215  105.537 1.00 32.93  ? 315 PHE A CE1 1 
ATOM   1947 C  CE2 . PHE A 1 315 ? 109.379 99.487  104.085 1.00 52.39  ? 315 PHE A CE2 1 
ATOM   1948 C  CZ  . PHE A 1 315 ? 108.808 98.284  104.441 1.00 43.45  ? 315 PHE A CZ  1 
ATOM   1949 N  N   . TYR A 1 316 ? 107.865 103.719 109.428 1.00 42.47  ? 316 TYR A N   1 
ATOM   1950 C  CA  . TYR A 1 316 ? 108.109 105.029 110.018 1.00 29.06  ? 316 TYR A CA  1 
ATOM   1951 C  C   . TYR A 1 316 ? 109.000 104.925 111.249 1.00 36.83  ? 316 TYR A C   1 
ATOM   1952 O  O   . TYR A 1 316 ? 109.870 105.775 111.465 1.00 30.42  ? 316 TYR A O   1 
ATOM   1953 C  CB  . TYR A 1 316 ? 106.772 105.685 110.367 1.00 39.45  ? 316 TYR A CB  1 
ATOM   1954 C  CG  . TYR A 1 316 ? 106.852 107.107 110.877 1.00 40.67  ? 316 TYR A CG  1 
ATOM   1955 C  CD1 . TYR A 1 316 ? 107.100 107.373 112.217 1.00 41.27  ? 316 TYR A CD1 1 
ATOM   1956 C  CD2 . TYR A 1 316 ? 106.652 108.182 110.024 1.00 37.76  ? 316 TYR A CD2 1 
ATOM   1957 C  CE1 . TYR A 1 316 ? 107.162 108.667 112.687 1.00 43.19  ? 316 TYR A CE1 1 
ATOM   1958 C  CE2 . TYR A 1 316 ? 106.712 109.481 110.487 1.00 39.59  ? 316 TYR A CE2 1 
ATOM   1959 C  CZ  . TYR A 1 316 ? 106.968 109.716 111.819 1.00 42.06  ? 316 TYR A CZ  1 
ATOM   1960 O  OH  . TYR A 1 316 ? 107.029 111.007 112.286 1.00 46.01  ? 316 TYR A OH  1 
ATOM   1961 N  N   . SER A 1 317 ? 108.797 103.890 112.069 1.00 38.03  ? 317 SER A N   1 
ATOM   1962 C  CA  . SER A 1 317 ? 109.560 103.768 113.307 1.00 30.01  ? 317 SER A CA  1 
ATOM   1963 C  C   . SER A 1 317 ? 111.027 103.454 113.047 1.00 37.70  ? 317 SER A C   1 
ATOM   1964 O  O   . SER A 1 317 ? 111.894 103.874 113.821 1.00 46.22  ? 317 SER A O   1 
ATOM   1965 C  CB  . SER A 1 317 ? 108.938 102.697 114.198 1.00 44.83  ? 317 SER A CB  1 
ATOM   1966 O  OG  . SER A 1 317 ? 109.686 102.526 115.387 1.00 48.25  ? 317 SER A OG  1 
ATOM   1967 N  N   . LEU A 1 318 ? 111.327 102.716 111.979 1.00 40.51  ? 318 LEU A N   1 
ATOM   1968 C  CA  . LEU A 1 318 ? 112.702 102.355 111.664 1.00 36.64  ? 318 LEU A CA  1 
ATOM   1969 C  C   . LEU A 1 318 ? 113.400 103.364 110.763 1.00 44.13  ? 318 LEU A C   1 
ATOM   1970 O  O   . LEU A 1 318 ? 114.625 103.295 110.616 1.00 38.71  ? 318 LEU A O   1 
ATOM   1971 C  CB  . LEU A 1 318 ? 112.745 100.974 111.001 1.00 41.73  ? 318 LEU A CB  1 
ATOM   1972 C  CG  . LEU A 1 318 ? 112.532 99.760  111.908 1.00 43.98  ? 318 LEU A CG  1 
ATOM   1973 C  CD1 . LEU A 1 318 ? 112.347 98.501  111.080 1.00 34.84  ? 318 LEU A CD1 1 
ATOM   1974 C  CD2 . LEU A 1 318 ? 113.688 99.597  112.884 1.00 43.36  ? 318 LEU A CD2 1 
ATOM   1975 N  N   . GLY A 1 319 ? 112.663 104.298 110.169 1.00 51.49  ? 319 GLY A N   1 
ATOM   1976 C  CA  . GLY A 1 319 ? 113.256 105.246 109.244 1.00 42.39  ? 319 GLY A CA  1 
ATOM   1977 C  C   . GLY A 1 319 ? 113.708 104.635 107.938 1.00 49.56  ? 319 GLY A C   1 
ATOM   1978 O  O   . GLY A 1 319 ? 114.810 104.936 107.465 1.00 58.45  ? 319 GLY A O   1 
ATOM   1979 N  N   . CYS A 1 320 ? 112.879 103.780 107.334 1.00 42.11  ? 320 CYS A N   1 
ATOM   1980 C  CA  . CYS A 1 320 ? 113.319 103.000 106.181 1.00 44.50  ? 320 CYS A CA  1 
ATOM   1981 C  C   . CYS A 1 320 ? 113.534 103.876 104.951 1.00 56.37  ? 320 CYS A C   1 
ATOM   1982 O  O   . CYS A 1 320 ? 114.570 103.779 104.287 1.00 58.12  ? 320 CYS A O   1 
ATOM   1983 C  CB  . CYS A 1 320 ? 112.312 101.888 105.888 1.00 54.17  ? 320 CYS A CB  1 
ATOM   1984 S  SG  . CYS A 1 320 ? 112.609 100.366 106.818 1.00 63.97  ? 320 CYS A SG  1 
ATOM   1985 N  N   . ALA A 1 321 ? 112.576 104.736 104.623 1.00 46.95  ? 321 ALA A N   1 
ATOM   1986 C  CA  . ALA A 1 321 ? 112.663 105.558 103.419 1.00 46.14  ? 321 ALA A CA  1 
ATOM   1987 C  C   . ALA A 1 321 ? 112.889 107.030 103.751 1.00 53.17  ? 321 ALA A C   1 
ATOM   1988 O  O   . ALA A 1 321 ? 112.441 107.923 103.030 1.00 58.26  ? 321 ALA A O   1 
ATOM   1989 C  CB  . ALA A 1 321 ? 111.418 105.389 102.554 1.00 44.14  ? 321 ALA A CB  1 
ATOM   1990 N  N   . TRP A 1 322 ? 113.592 107.296 104.850 1.00 48.16  ? 322 TRP A N   1 
ATOM   1991 C  CA  . TRP A 1 322 ? 113.924 108.662 105.233 1.00 30.76  ? 322 TRP A CA  1 
ATOM   1992 C  C   . TRP A 1 322 ? 115.204 109.154 104.574 1.00 46.00  ? 322 TRP A C   1 
ATOM   1993 O  O   . TRP A 1 322 ? 115.377 110.365 104.400 1.00 53.82  ? 322 TRP A O   1 
ATOM   1994 C  CB  . TRP A 1 322 ? 114.067 108.772 106.754 1.00 37.90  ? 322 TRP A CB  1 
ATOM   1995 C  CG  . TRP A 1 322 ? 112.792 108.577 107.524 1.00 43.47  ? 322 TRP A CG  1 
ATOM   1996 C  CD1 . TRP A 1 322 ? 111.750 107.759 107.198 1.00 42.65  ? 322 TRP A CD1 1 
ATOM   1997 C  CD2 . TRP A 1 322 ? 112.430 109.212 108.756 1.00 52.49  ? 322 TRP A CD2 1 
ATOM   1998 N  NE1 . TRP A 1 322 ? 110.763 107.847 108.147 1.00 41.75  ? 322 TRP A NE1 1 
ATOM   1999 C  CE2 . TRP A 1 322 ? 111.156 108.733 109.114 1.00 50.09  ? 322 TRP A CE2 1 
ATOM   2000 C  CE3 . TRP A 1 322 ? 113.059 110.142 109.588 1.00 39.55  ? 322 TRP A CE3 1 
ATOM   2001 C  CZ2 . TRP A 1 322 ? 110.501 109.151 110.269 1.00 42.56  ? 322 TRP A CZ2 1 
ATOM   2002 C  CZ3 . TRP A 1 322 ? 112.406 110.554 110.734 1.00 44.47  ? 322 TRP A CZ3 1 
ATOM   2003 C  CH2 . TRP A 1 322 ? 111.140 110.062 111.062 1.00 42.27  ? 322 TRP A CH2 1 
ATOM   2004 N  N   . GLY A 1 323 ? 116.102 108.243 104.205 1.00 46.25  ? 323 GLY A N   1 
ATOM   2005 C  CA  . GLY A 1 323 ? 117.369 108.592 103.603 1.00 38.02  ? 323 GLY A CA  1 
ATOM   2006 C  C   . GLY A 1 323 ? 118.516 108.743 104.577 1.00 47.83  ? 323 GLY A C   1 
ATOM   2007 O  O   . GLY A 1 323 ? 119.664 108.879 104.137 1.00 46.19  ? 323 GLY A O   1 
ATOM   2008 N  N   . GLY A 1 324 ? 118.245 108.723 105.883 1.00 47.56  ? 324 GLY A N   1 
ATOM   2009 C  CA  . GLY A 1 324 ? 119.309 108.886 106.857 1.00 41.34  ? 324 GLY A CA  1 
ATOM   2010 C  C   . GLY A 1 324 ? 120.121 107.635 107.104 1.00 49.60  ? 324 GLY A C   1 
ATOM   2011 O  O   . GLY A 1 324 ? 121.289 107.725 107.493 1.00 51.55  ? 324 GLY A O   1 
ATOM   2012 N  N   . LEU A 1 325 ? 119.527 106.459 106.893 1.00 52.98  ? 325 LEU A N   1 
ATOM   2013 C  CA  . LEU A 1 325 ? 120.242 105.210 107.136 1.00 44.81  ? 325 LEU A CA  1 
ATOM   2014 C  C   . LEU A 1 325 ? 121.410 105.041 106.171 1.00 50.21  ? 325 LEU A C   1 
ATOM   2015 O  O   . LEU A 1 325 ? 122.507 104.640 106.576 1.00 54.89  ? 325 LEU A O   1 
ATOM   2016 C  CB  . LEU A 1 325 ? 119.280 104.026 107.034 1.00 47.05  ? 325 LEU A CB  1 
ATOM   2017 C  CG  . LEU A 1 325 ? 118.201 103.920 108.114 1.00 49.12  ? 325 LEU A CG  1 
ATOM   2018 C  CD1 . LEU A 1 325 ? 117.267 102.759 107.824 1.00 48.86  ? 325 LEU A CD1 1 
ATOM   2019 C  CD2 . LEU A 1 325 ? 118.827 103.773 109.489 1.00 46.27  ? 325 LEU A CD2 1 
ATOM   2020 N  N   . ILE A 1 326 ? 121.194 105.345 104.889 1.00 42.02  ? 326 ILE A N   1 
ATOM   2021 C  CA  . ILE A 1 326 ? 122.265 105.219 103.904 1.00 44.60  ? 326 ILE A CA  1 
ATOM   2022 C  C   . ILE A 1 326 ? 123.387 106.204 104.204 1.00 49.19  ? 326 ILE A C   1 
ATOM   2023 O  O   . ILE A 1 326 ? 124.573 105.856 104.138 1.00 53.50  ? 326 ILE A O   1 
ATOM   2024 C  CB  . ILE A 1 326 ? 121.707 105.411 102.482 1.00 47.45  ? 326 ILE A CB  1 
ATOM   2025 C  CG1 . ILE A 1 326 ? 120.410 104.625 102.308 1.00 44.31  ? 326 ILE A CG1 1 
ATOM   2026 C  CG2 . ILE A 1 326 ? 122.724 104.975 101.444 1.00 40.93  ? 326 ILE A CG2 1 
ATOM   2027 C  CD1 . ILE A 1 326 ? 119.807 104.730 100.930 1.00 43.81  ? 326 ILE A CD1 1 
ATOM   2028 N  N   . THR A 1 327 ? 123.034 107.446 104.540 1.00 46.77  ? 327 THR A N   1 
ATOM   2029 C  CA  . THR A 1 327 ? 124.048 108.444 104.862 1.00 47.11  ? 327 THR A CA  1 
ATOM   2030 C  C   . THR A 1 327 ? 124.841 108.048 106.100 1.00 49.22  ? 327 THR A C   1 
ATOM   2031 O  O   . THR A 1 327 ? 126.066 108.210 106.136 1.00 56.78  ? 327 THR A O   1 
ATOM   2032 C  CB  . THR A 1 327 ? 123.394 109.812 105.059 1.00 49.14  ? 327 THR A CB  1 
ATOM   2033 O  OG1 . THR A 1 327 ? 122.497 110.074 103.973 1.00 56.62  ? 327 THR A OG1 1 
ATOM   2034 C  CG2 . THR A 1 327 ? 124.449 110.903 105.108 1.00 45.10  ? 327 THR A CG2 1 
ATOM   2035 N  N   . MET A 1 328 ? 124.162 107.528 107.126 1.00 43.91  ? 328 MET A N   1 
ATOM   2036 C  CA  . MET A 1 328 ? 124.863 107.088 108.328 1.00 45.98  ? 328 MET A CA  1 
ATOM   2037 C  C   . MET A 1 328 ? 125.784 105.911 108.035 1.00 58.71  ? 328 MET A C   1 
ATOM   2038 O  O   . MET A 1 328 ? 126.909 105.855 108.545 1.00 61.53  ? 328 MET A O   1 
ATOM   2039 C  CB  . MET A 1 328 ? 123.859 106.718 109.416 1.00 49.71  ? 328 MET A CB  1 
ATOM   2040 C  CG  . MET A 1 328 ? 123.699 107.765 110.499 1.00 55.86  ? 328 MET A CG  1 
ATOM   2041 S  SD  . MET A 1 328 ? 122.143 107.578 111.384 1.00 81.00  ? 328 MET A SD  1 
ATOM   2042 C  CE  . MET A 1 328 ? 121.553 109.265 111.370 1.00 58.88  ? 328 MET A CE  1 
ATOM   2043 N  N   . ALA A 1 329 ? 125.326 104.956 107.222 1.00 52.98  ? 329 ALA A N   1 
ATOM   2044 C  CA  . ALA A 1 329 ? 126.144 103.794 106.904 1.00 43.57  ? 329 ALA A CA  1 
ATOM   2045 C  C   . ALA A 1 329 ? 127.308 104.134 105.986 1.00 43.68  ? 329 ALA A C   1 
ATOM   2046 O  O   . ALA A 1 329 ? 128.294 103.391 105.960 1.00 53.51  ? 329 ALA A O   1 
ATOM   2047 C  CB  . ALA A 1 329 ? 125.284 102.704 106.267 1.00 38.54  ? 329 ALA A CB  1 
ATOM   2048 N  N   . SER A 1 330 ? 127.221 105.234 105.235 1.00 45.27  ? 330 SER A N   1 
ATOM   2049 C  CA  . SER A 1 330 ? 128.295 105.604 104.320 1.00 44.14  ? 330 SER A CA  1 
ATOM   2050 C  C   . SER A 1 330 ? 129.621 105.871 105.023 1.00 50.89  ? 330 SER A C   1 
ATOM   2051 O  O   . SER A 1 330 ? 130.664 105.835 104.364 1.00 55.74  ? 330 SER A O   1 
ATOM   2052 C  CB  . SER A 1 330 ? 127.890 106.835 103.509 1.00 45.88  ? 330 SER A CB  1 
ATOM   2053 O  OG  . SER A 1 330 ? 127.976 108.013 104.288 1.00 55.17  ? 330 SER A OG  1 
ATOM   2054 N  N   . TYR A 1 331 ? 129.612 106.138 106.327 1.00 57.96  ? 331 TYR A N   1 
ATOM   2055 C  CA  . TYR A 1 331 ? 130.833 106.383 107.082 1.00 50.93  ? 331 TYR A CA  1 
ATOM   2056 C  C   . TYR A 1 331 ? 131.376 105.132 107.760 1.00 56.25  ? 331 TYR A C   1 
ATOM   2057 O  O   . TYR A 1 331 ? 132.377 105.220 108.475 1.00 58.68  ? 331 TYR A O   1 
ATOM   2058 C  CB  . TYR A 1 331 ? 130.594 107.473 108.132 1.00 54.68  ? 331 TYR A CB  1 
ATOM   2059 C  CG  . TYR A 1 331 ? 130.066 108.771 107.568 1.00 63.13  ? 331 TYR A CG  1 
ATOM   2060 C  CD1 . TYR A 1 331 ? 130.907 109.659 106.914 1.00 63.01  ? 331 TYR A CD1 1 
ATOM   2061 C  CD2 . TYR A 1 331 ? 128.726 109.111 107.693 1.00 56.47  ? 331 TYR A CD2 1 
ATOM   2062 C  CE1 . TYR A 1 331 ? 130.431 110.846 106.398 1.00 59.09  ? 331 TYR A CE1 1 
ATOM   2063 C  CE2 . TYR A 1 331 ? 128.241 110.296 107.179 1.00 55.16  ? 331 TYR A CE2 1 
ATOM   2064 C  CZ  . TYR A 1 331 ? 129.098 111.159 106.533 1.00 61.55  ? 331 TYR A CZ  1 
ATOM   2065 O  OH  . TYR A 1 331 ? 128.620 112.342 106.019 1.00 66.31  ? 331 TYR A OH  1 
ATOM   2066 N  N   . ASN A 1 332 ? 130.747 103.979 107.559 1.00 59.97  ? 332 ASN A N   1 
ATOM   2067 C  CA  . ASN A 1 332 ? 131.202 102.748 108.185 1.00 52.60  ? 332 ASN A CA  1 
ATOM   2068 C  C   . ASN A 1 332 ? 132.371 102.143 107.412 1.00 54.01  ? 332 ASN A C   1 
ATOM   2069 O  O   . ASN A 1 332 ? 132.541 102.365 106.211 1.00 65.19  ? 332 ASN A O   1 
ATOM   2070 C  CB  . ASN A 1 332 ? 130.063 101.734 108.271 1.00 49.95  ? 332 ASN A CB  1 
ATOM   2071 C  CG  . ASN A 1 332 ? 129.142 101.991 109.440 1.00 58.72  ? 332 ASN A CG  1 
ATOM   2072 O  OD1 . ASN A 1 332 ? 129.583 102.387 110.517 1.00 67.11  ? 332 ASN A OD1 1 
ATOM   2073 N  ND2 . ASN A 1 332 ? 127.853 101.753 109.239 1.00 57.44  ? 332 ASN A ND2 1 
ATOM   2074 N  N   . LYS A 1 333 ? 133.179 101.362 108.124 1.00 49.50  ? 333 LYS A N   1 
ATOM   2075 C  CA  . LYS A 1 333 ? 134.285 100.656 107.499 1.00 49.78  ? 333 LYS A CA  1 
ATOM   2076 C  C   . LYS A 1 333 ? 133.761 99.532  106.610 1.00 50.26  ? 333 LYS A C   1 
ATOM   2077 O  O   . LYS A 1 333 ? 132.624 99.073  106.748 1.00 58.48  ? 333 LYS A O   1 
ATOM   2078 C  CB  . LYS A 1 333 ? 135.232 100.097 108.560 1.00 51.95  ? 333 LYS A CB  1 
ATOM   2079 C  CG  . LYS A 1 333 ? 135.598 101.099 109.640 1.00 58.15  ? 333 LYS A CG  1 
ATOM   2080 C  CD  . LYS A 1 333 ? 136.856 100.690 110.384 1.00 59.82  ? 333 LYS A CD  1 
ATOM   2081 C  CE  . LYS A 1 333 ? 138.086 101.365 109.804 1.00 62.42  ? 333 LYS A CE  1 
ATOM   2082 N  NZ  . LYS A 1 333 ? 139.246 100.436 109.730 1.00 65.84  ? 333 LYS A NZ  1 
ATOM   2083 N  N   . PHE A 1 334 ? 134.610 99.093  105.678 1.00 48.35  ? 334 PHE A N   1 
ATOM   2084 C  CA  . PHE A 1 334 ? 134.184 98.096  104.699 1.00 49.04  ? 334 PHE A CA  1 
ATOM   2085 C  C   . PHE A 1 334 ? 133.812 96.777  105.364 1.00 46.80  ? 334 PHE A C   1 
ATOM   2086 O  O   . PHE A 1 334 ? 132.778 96.182  105.041 1.00 57.41  ? 334 PHE A O   1 
ATOM   2087 C  CB  . PHE A 1 334 ? 135.284 97.876  103.661 1.00 39.48  ? 334 PHE A CB  1 
ATOM   2088 C  CG  . PHE A 1 334 ? 134.796 97.251  102.384 1.00 44.94  ? 334 PHE A CG  1 
ATOM   2089 C  CD1 . PHE A 1 334 ? 133.898 97.916  101.569 1.00 49.02  ? 334 PHE A CD1 1 
ATOM   2090 C  CD2 . PHE A 1 334 ? 135.232 95.994  102.003 1.00 47.12  ? 334 PHE A CD2 1 
ATOM   2091 C  CE1 . PHE A 1 334 ? 133.450 97.342  100.398 1.00 42.28  ? 334 PHE A CE1 1 
ATOM   2092 C  CE2 . PHE A 1 334 ? 134.786 95.417  100.833 1.00 41.92  ? 334 PHE A CE2 1 
ATOM   2093 C  CZ  . PHE A 1 334 ? 133.894 96.091  100.030 1.00 41.35  ? 334 PHE A CZ  1 
ATOM   2094 N  N   . HIS A 1 335 ? 134.632 96.307  106.302 1.00 44.95  ? 335 HIS A N   1 
ATOM   2095 C  CA  . HIS A 1 335 ? 134.450 94.995  106.906 1.00 41.73  ? 335 HIS A CA  1 
ATOM   2096 C  C   . HIS A 1 335 ? 133.623 95.039  108.186 1.00 46.30  ? 335 HIS A C   1 
ATOM   2097 O  O   . HIS A 1 335 ? 133.674 94.093  108.979 1.00 53.16  ? 335 HIS A O   1 
ATOM   2098 C  CB  . HIS A 1 335 ? 135.811 94.351  107.174 1.00 43.21  ? 335 HIS A CB  1 
ATOM   2099 C  CG  . HIS A 1 335 ? 136.591 94.055  105.932 1.00 50.00  ? 335 HIS A CG  1 
ATOM   2100 N  ND1 . HIS A 1 335 ? 136.049 93.387  104.855 1.00 48.33  ? 335 HIS A ND1 1 
ATOM   2101 C  CD2 . HIS A 1 335 ? 137.870 94.339  105.593 1.00 55.86  ? 335 HIS A CD2 1 
ATOM   2102 C  CE1 . HIS A 1 335 ? 136.961 93.270  103.907 1.00 51.55  ? 335 HIS A CE1 1 
ATOM   2103 N  NE2 . HIS A 1 335 ? 138.076 93.839  104.330 1.00 52.54  ? 335 HIS A NE2 1 
ATOM   2104 N  N   . ASN A 1 336 ? 132.866 96.110  108.403 1.00 46.88  ? 336 ASN A N   1 
ATOM   2105 C  CA  . ASN A 1 336 ? 131.968 96.174  109.546 1.00 40.95  ? 336 ASN A CA  1 
ATOM   2106 C  C   . ASN A 1 336 ? 130.807 95.205  109.353 1.00 55.13  ? 336 ASN A C   1 
ATOM   2107 O  O   . ASN A 1 336 ? 130.337 94.989  108.233 1.00 64.23  ? 336 ASN A O   1 
ATOM   2108 C  CB  . ASN A 1 336 ? 131.455 97.602  109.730 1.00 43.49  ? 336 ASN A CB  1 
ATOM   2109 C  CG  . ASN A 1 336 ? 130.351 97.701  110.760 1.00 52.86  ? 336 ASN A CG  1 
ATOM   2110 O  OD1 . ASN A 1 336 ? 130.607 97.679  111.962 1.00 66.54  ? 336 ASN A OD1 1 
ATOM   2111 N  ND2 . ASN A 1 336 ? 129.116 97.823  110.294 1.00 48.33  ? 336 ASN A ND2 1 
ATOM   2112 N  N   . ASN A 1 337 ? 130.351 94.610  110.453 1.00 53.14  ? 337 ASN A N   1 
ATOM   2113 C  CA  . ASN A 1 337 ? 129.274 93.621  110.422 1.00 47.90  ? 337 ASN A CA  1 
ATOM   2114 C  C   . ASN A 1 337 ? 127.941 94.352  110.530 1.00 49.56  ? 337 ASN A C   1 
ATOM   2115 O  O   . ASN A 1 337 ? 127.494 94.692  111.627 1.00 56.14  ? 337 ASN A O   1 
ATOM   2116 C  CB  . ASN A 1 337 ? 129.453 92.607  111.546 1.00 46.09  ? 337 ASN A CB  1 
ATOM   2117 C  CG  . ASN A 1 337 ? 128.686 91.324  111.305 1.00 53.79  ? 337 ASN A CG  1 
ATOM   2118 O  OD1 . ASN A 1 337 ? 127.854 91.245  110.405 1.00 60.08  ? 337 ASN A OD1 1 
ATOM   2119 N  ND2 . ASN A 1 337 ? 128.966 90.309  112.111 1.00 52.97  ? 337 ASN A ND2 1 
ATOM   2120 N  N   . CYS A 1 338 ? 127.302 94.597  109.384 1.00 45.18  ? 338 CYS A N   1 
ATOM   2121 C  CA  . CYS A 1 338 ? 126.031 95.312  109.364 1.00 50.31  ? 338 CYS A CA  1 
ATOM   2122 C  C   . CYS A 1 338 ? 124.841 94.421  109.695 1.00 55.30  ? 338 CYS A C   1 
ATOM   2123 O  O   . CYS A 1 338 ? 123.788 94.938  110.080 1.00 59.65  ? 338 CYS A O   1 
ATOM   2124 C  CB  . CYS A 1 338 ? 125.815 95.967  107.998 1.00 49.59  ? 338 CYS A CB  1 
ATOM   2125 S  SG  . CYS A 1 338 ? 125.914 94.839  106.590 1.00 62.91  ? 338 CYS A SG  1 
ATOM   2126 N  N   . TYR A 1 339 ? 124.984 93.102  109.561 1.00 44.56  ? 339 TYR A N   1 
ATOM   2127 C  CA  . TYR A 1 339 ? 123.888 92.188  109.868 1.00 45.44  ? 339 TYR A CA  1 
ATOM   2128 C  C   . TYR A 1 339 ? 123.557 92.210  111.358 1.00 53.90  ? 339 TYR A C   1 
ATOM   2129 O  O   . TYR A 1 339 ? 122.390 92.363  111.750 1.00 59.65  ? 339 TYR A O   1 
ATOM   2130 C  CB  . TYR A 1 339 ? 124.270 90.782  109.396 1.00 43.45  ? 339 TYR A CB  1 
ATOM   2131 C  CG  . TYR A 1 339 ? 123.400 89.653  109.893 1.00 48.60  ? 339 TYR A CG  1 
ATOM   2132 C  CD1 . TYR A 1 339 ? 122.021 89.697  109.763 1.00 56.54  ? 339 TYR A CD1 1 
ATOM   2133 C  CD2 . TYR A 1 339 ? 123.968 88.526  110.471 1.00 46.65  ? 339 TYR A CD2 1 
ATOM   2134 C  CE1 . TYR A 1 339 ? 121.231 88.658  110.212 1.00 53.75  ? 339 TYR A CE1 1 
ATOM   2135 C  CE2 . TYR A 1 339 ? 123.187 87.485  110.921 1.00 43.38  ? 339 TYR A CE2 1 
ATOM   2136 C  CZ  . TYR A 1 339 ? 121.820 87.555  110.789 1.00 52.42  ? 339 TYR A CZ  1 
ATOM   2137 O  OH  . TYR A 1 339 ? 121.038 86.517  111.237 1.00 63.34  ? 339 TYR A OH  1 
ATOM   2138 N  N   . ARG A 1 340 ? 124.584 92.081  112.201 1.00 49.90  ? 340 ARG A N   1 
ATOM   2139 C  CA  . ARG A 1 340 ? 124.391 92.148  113.645 1.00 44.30  ? 340 ARG A CA  1 
ATOM   2140 C  C   . ARG A 1 340 ? 123.824 93.496  114.063 1.00 45.81  ? 340 ARG A C   1 
ATOM   2141 O  O   . ARG A 1 340 ? 122.912 93.565  114.898 1.00 53.25  ? 340 ARG A O   1 
ATOM   2142 C  CB  . ARG A 1 340 ? 125.722 91.889  114.350 1.00 48.78  ? 340 ARG A CB  1 
ATOM   2143 C  CG  . ARG A 1 340 ? 125.611 91.212  115.700 1.00 56.71  ? 340 ARG A CG  1 
ATOM   2144 C  CD  . ARG A 1 340 ? 126.920 91.332  116.462 1.00 52.64  ? 340 ARG A CD  1 
ATOM   2145 N  NE  . ARG A 1 340 ? 127.568 92.616  116.223 1.00 60.97  ? 340 ARG A NE  1 
ATOM   2146 C  CZ  . ARG A 1 340 ? 128.841 92.762  115.881 1.00 66.64  ? 340 ARG A CZ  1 
ATOM   2147 N  NH1 . ARG A 1 340 ? 129.642 91.719  115.737 1.00 60.60  ? 340 ARG A NH1 1 
ATOM   2148 N  NH2 . ARG A 1 340 ? 129.322 93.985  115.678 1.00 61.34  ? 340 ARG A NH2 1 
ATOM   2149 N  N   . ASP A 1 341 ? 124.356 94.581  113.496 1.00 46.84  ? 341 ASP A N   1 
ATOM   2150 C  CA  . ASP A 1 341 ? 123.874 95.915  113.832 1.00 44.78  ? 341 ASP A CA  1 
ATOM   2151 C  C   . ASP A 1 341 ? 122.405 96.073  113.468 1.00 44.79  ? 341 ASP A C   1 
ATOM   2152 O  O   . ASP A 1 341 ? 121.615 96.609  114.252 1.00 56.27  ? 341 ASP A O   1 
ATOM   2153 C  CB  . ASP A 1 341 ? 124.720 96.970  113.119 1.00 51.17  ? 341 ASP A CB  1 
ATOM   2154 C  CG  . ASP A 1 341 ? 126.153 96.997  113.606 1.00 62.38  ? 341 ASP A CG  1 
ATOM   2155 O  OD1 . ASP A 1 341 ? 126.602 95.992  114.194 1.00 66.60  ? 341 ASP A OD1 1 
ATOM   2156 O  OD2 . ASP A 1 341 ? 126.834 98.021  113.395 1.00 60.80  ? 341 ASP A OD2 1 
ATOM   2157 N  N   . SER A 1 342 ? 122.020 95.606  112.279 1.00 38.95  ? 342 SER A N   1 
ATOM   2158 C  CA  . SER A 1 342 ? 120.631 95.723  111.854 1.00 45.90  ? 342 SER A CA  1 
ATOM   2159 C  C   . SER A 1 342 ? 119.707 94.948  112.782 1.00 48.43  ? 342 SER A C   1 
ATOM   2160 O  O   . SER A 1 342 ? 118.666 95.463  113.212 1.00 59.39  ? 342 SER A O   1 
ATOM   2161 C  CB  . SER A 1 342 ? 120.481 95.236  110.413 1.00 41.65  ? 342 SER A CB  1 
ATOM   2162 O  OG  . SER A 1 342 ? 120.695 93.840  110.325 1.00 52.81  ? 342 SER A OG  1 
ATOM   2163 N  N   . VAL A 1 343 ? 120.083 93.712  113.123 1.00 44.81  ? 343 VAL A N   1 
ATOM   2164 C  CA  . VAL A 1 343 ? 119.236 92.905  114.000 1.00 42.73  ? 343 VAL A CA  1 
ATOM   2165 C  C   . VAL A 1 343 ? 119.087 93.574  115.363 1.00 46.11  ? 343 VAL A C   1 
ATOM   2166 O  O   . VAL A 1 343 ? 117.973 93.713  115.891 1.00 51.10  ? 343 VAL A O   1 
ATOM   2167 C  CB  . VAL A 1 343 ? 119.800 91.478  114.129 1.00 45.67  ? 343 VAL A CB  1 
ATOM   2168 C  CG1 . VAL A 1 343 ? 119.000 90.682  115.142 1.00 44.43  ? 343 VAL A CG1 1 
ATOM   2169 C  CG2 . VAL A 1 343 ? 119.784 90.783  112.782 1.00 45.34  ? 343 VAL A CG2 1 
ATOM   2170 N  N   . ILE A 1 344 ? 120.206 94.018  115.944 1.00 49.26  ? 344 ILE A N   1 
ATOM   2171 C  CA  . ILE A 1 344 ? 120.172 94.601  117.284 1.00 40.52  ? 344 ILE A CA  1 
ATOM   2172 C  C   . ILE A 1 344 ? 119.342 95.878  117.293 1.00 39.66  ? 344 ILE A C   1 
ATOM   2173 O  O   . ILE A 1 344 ? 118.502 96.085  118.177 1.00 50.68  ? 344 ILE A O   1 
ATOM   2174 C  CB  . ILE A 1 344 ? 121.602 94.853  117.796 1.00 40.60  ? 344 ILE A CB  1 
ATOM   2175 C  CG1 . ILE A 1 344 ? 122.284 93.531  118.149 1.00 44.02  ? 344 ILE A CG1 1 
ATOM   2176 C  CG2 . ILE A 1 344 ? 121.586 95.774  119.002 1.00 46.86  ? 344 ILE A CG2 1 
ATOM   2177 C  CD1 . ILE A 1 344 ? 123.782 93.642  118.296 1.00 45.75  ? 344 ILE A CD1 1 
ATOM   2178 N  N   . ILE A 1 345 ? 119.558 96.752  116.306 1.00 39.97  ? 345 ILE A N   1 
ATOM   2179 C  CA  . ILE A 1 345 ? 118.833 98.017  116.269 1.00 40.96  ? 345 ILE A CA  1 
ATOM   2180 C  C   . ILE A 1 345 ? 117.342 97.779  116.069 1.00 42.87  ? 345 ILE A C   1 
ATOM   2181 O  O   . ILE A 1 345 ? 116.512 98.420  116.723 1.00 51.86  ? 345 ILE A O   1 
ATOM   2182 C  CB  . ILE A 1 345 ? 119.413 98.943  115.184 1.00 44.39  ? 345 ILE A CB  1 
ATOM   2183 C  CG1 . ILE A 1 345 ? 120.825 99.388  115.565 1.00 39.89  ? 345 ILE A CG1 1 
ATOM   2184 C  CG2 . ILE A 1 345 ? 118.527 100.159 114.986 1.00 44.04  ? 345 ILE A CG2 1 
ATOM   2185 C  CD1 . ILE A 1 345 ? 121.647 99.861  114.395 1.00 44.63  ? 345 ILE A CD1 1 
ATOM   2186 N  N   . SER A 1 346 ? 116.972 96.859  115.173 1.00 43.40  ? 346 SER A N   1 
ATOM   2187 C  CA  . SER A 1 346 ? 115.555 96.590  114.948 1.00 41.61  ? 346 SER A CA  1 
ATOM   2188 C  C   . SER A 1 346 ? 114.881 96.059  116.208 1.00 41.30  ? 346 SER A C   1 
ATOM   2189 O  O   . SER A 1 346 ? 113.796 96.526  116.584 1.00 37.97  ? 346 SER A O   1 
ATOM   2190 C  CB  . SER A 1 346 ? 115.385 95.602  113.795 1.00 39.86  ? 346 SER A CB  1 
ATOM   2191 O  OG  . SER A 1 346 ? 115.837 96.161  112.575 1.00 48.36  ? 346 SER A OG  1 
ATOM   2192 N  N   . ILE A 1 347 ? 115.511 95.090  116.881 1.00 45.75  ? 347 ILE A N   1 
ATOM   2193 C  CA  . ILE A 1 347 ? 114.901 94.523  118.081 1.00 40.33  ? 347 ILE A CA  1 
ATOM   2194 C  C   . ILE A 1 347 ? 114.795 95.572  119.182 1.00 43.61  ? 347 ILE A C   1 
ATOM   2195 O  O   . ILE A 1 347 ? 113.762 95.681  119.853 1.00 50.78  ? 347 ILE A O   1 
ATOM   2196 C  CB  . ILE A 1 347 ? 115.681 93.281  118.550 1.00 43.48  ? 347 ILE A CB  1 
ATOM   2197 C  CG1 . ILE A 1 347 ? 115.728 92.228  117.439 1.00 46.05  ? 347 ILE A CG1 1 
ATOM   2198 C  CG2 . ILE A 1 347 ? 115.068 92.714  119.823 1.00 43.73  ? 347 ILE A CG2 1 
ATOM   2199 C  CD1 . ILE A 1 347 ? 114.609 91.214  117.491 1.00 47.33  ? 347 ILE A CD1 1 
ATOM   2200 N  N   . THR A 1 348 ? 115.851 96.366  119.383 1.00 47.52  ? 348 THR A N   1 
ATOM   2201 C  CA  . THR A 1 348 ? 115.814 97.395  120.418 1.00 44.97  ? 348 THR A CA  1 
ATOM   2202 C  C   . THR A 1 348 ? 114.743 98.439  120.128 1.00 37.09  ? 348 THR A C   1 
ATOM   2203 O  O   . THR A 1 348 ? 114.018 98.863  121.035 1.00 43.30  ? 348 THR A O   1 
ATOM   2204 C  CB  . THR A 1 348 ? 117.186 98.058  120.549 1.00 49.73  ? 348 THR A CB  1 
ATOM   2205 O  OG1 . THR A 1 348 ? 118.146 97.091  120.989 1.00 49.42  ? 348 THR A OG1 1 
ATOM   2206 C  CG2 . THR A 1 348 ? 117.137 99.201  121.548 1.00 43.42  ? 348 THR A CG2 1 
ATOM   2207 N  N   . ASN A 1 349 ? 114.626 98.866  118.868 1.00 37.82  ? 349 ASN A N   1 
ATOM   2208 C  CA  . ASN A 1 349 ? 113.631 99.874  118.520 1.00 32.43  ? 349 ASN A CA  1 
ATOM   2209 C  C   . ASN A 1 349 ? 112.215 99.350  118.710 1.00 37.97  ? 349 ASN A C   1 
ATOM   2210 O  O   . ASN A 1 349 ? 111.352 100.058 119.241 1.00 43.47  ? 349 ASN A O   1 
ATOM   2211 C  CB  . ASN A 1 349 ? 113.842 100.340 117.080 1.00 39.24  ? 349 ASN A CB  1 
ATOM   2212 C  CG  . ASN A 1 349 ? 112.596 100.957 116.479 1.00 48.21  ? 349 ASN A CG  1 
ATOM   2213 O  OD1 . ASN A 1 349 ? 111.853 100.301 115.751 1.00 52.49  ? 349 ASN A OD1 1 
ATOM   2214 N  ND2 . ASN A 1 349 ? 112.359 102.226 116.784 1.00 47.03  ? 349 ASN A ND2 1 
ATOM   2215 N  N   . CYS A 1 350 ? 111.950 98.112  118.288 1.00 53.53  ? 350 CYS A N   1 
ATOM   2216 C  CA  . CYS A 1 350 ? 110.588 97.602  118.377 1.00 43.71  ? 350 CYS A CA  1 
ATOM   2217 C  C   . CYS A 1 350 ? 110.229 97.087  119.764 1.00 41.94  ? 350 CYS A C   1 
ATOM   2218 O  O   . CYS A 1 350 ? 109.043 96.886  120.043 1.00 54.89  ? 350 CYS A O   1 
ATOM   2219 C  CB  . CYS A 1 350 ? 110.367 96.503  117.339 1.00 50.33  ? 350 CYS A CB  1 
ATOM   2220 S  SG  . CYS A 1 350 ? 109.954 97.147  115.704 1.00 74.58  ? 350 CYS A SG  1 
ATOM   2221 N  N   . ALA A 1 351 ? 111.212 96.867  120.639 1.00 42.37  ? 351 ALA A N   1 
ATOM   2222 C  CA  . ALA A 1 351 ? 110.896 96.485  122.010 1.00 34.94  ? 351 ALA A CA  1 
ATOM   2223 C  C   . ALA A 1 351 ? 110.550 97.685  122.881 1.00 42.30  ? 351 ALA A C   1 
ATOM   2224 O  O   . ALA A 1 351 ? 110.021 97.503  123.982 1.00 53.27  ? 351 ALA A O   1 
ATOM   2225 C  CB  . ALA A 1 351 ? 112.063 95.714  122.625 1.00 40.65  ? 351 ALA A CB  1 
ATOM   2226 N  N   . THR A 1 352 ? 110.835 98.903  122.416 1.00 48.72  ? 352 THR A N   1 
ATOM   2227 C  CA  . THR A 1 352 ? 110.536 100.098 123.197 1.00 42.97  ? 352 THR A CA  1 
ATOM   2228 C  C   . THR A 1 352 ? 109.080 100.525 123.057 1.00 50.93  ? 352 THR A C   1 
ATOM   2229 O  O   . THR A 1 352 ? 108.514 101.097 123.994 1.00 59.87  ? 352 THR A O   1 
ATOM   2230 C  CB  . THR A 1 352 ? 111.462 101.242 122.776 1.00 47.95  ? 352 THR A CB  1 
ATOM   2231 O  OG1 . THR A 1 352 ? 112.818 100.781 122.769 1.00 53.56  ? 352 THR A OG1 1 
ATOM   2232 C  CG2 . THR A 1 352 ? 111.346 102.413 123.738 1.00 44.40  ? 352 THR A CG2 1 
ATOM   2233 N  N   . SER A 1 353 ? 108.461 100.257 121.906 1.00 47.52  ? 353 SER A N   1 
ATOM   2234 C  CA  . SER A 1 353 ? 107.068 100.634 121.699 1.00 34.83  ? 353 SER A CA  1 
ATOM   2235 C  C   . SER A 1 353 ? 106.119 99.786  122.538 1.00 42.07  ? 353 SER A C   1 
ATOM   2236 O  O   . SER A 1 353 ? 105.072 100.275 122.977 1.00 52.49  ? 353 SER A O   1 
ATOM   2237 C  CB  . SER A 1 353 ? 106.711 100.523 120.218 1.00 32.64  ? 353 SER A CB  1 
ATOM   2238 O  OG  . SER A 1 353 ? 107.701 101.129 119.408 1.00 42.52  ? 353 SER A OG  1 
ATOM   2239 N  N   . VAL A 1 354 ? 106.464 98.519  122.768 1.00 43.62  ? 354 VAL A N   1 
ATOM   2240 C  CA  . VAL A 1 354 ? 105.589 97.626  123.522 1.00 47.56  ? 354 VAL A CA  1 
ATOM   2241 C  C   . VAL A 1 354 ? 105.486 98.070  124.978 1.00 51.33  ? 354 VAL A C   1 
ATOM   2242 O  O   . VAL A 1 354 ? 104.409 98.017  125.582 1.00 56.88  ? 354 VAL A O   1 
ATOM   2243 C  CB  . VAL A 1 354 ? 106.086 96.175  123.396 1.00 46.08  ? 354 VAL A CB  1 
ATOM   2244 C  CG1 . VAL A 1 354 ? 105.246 95.241  124.250 1.00 46.45  ? 354 VAL A CG1 1 
ATOM   2245 C  CG2 . VAL A 1 354 ? 106.065 95.737  121.943 1.00 38.10  ? 354 VAL A CG2 1 
ATOM   2246 N  N   . TYR A 1 355 ? 106.599 98.517  125.563 1.00 42.67  ? 355 TYR A N   1 
ATOM   2247 C  CA  . TYR A 1 355 ? 106.588 99.003  126.941 1.00 44.81  ? 355 TYR A CA  1 
ATOM   2248 C  C   . TYR A 1 355 ? 105.688 100.227 127.088 1.00 50.19  ? 355 TYR A C   1 
ATOM   2249 O  O   . TYR A 1 355 ? 104.857 100.309 128.008 1.00 58.70  ? 355 TYR A O   1 
ATOM   2250 C  CB  . TYR A 1 355 ? 108.021 99.328  127.365 1.00 49.35  ? 355 TYR A CB  1 
ATOM   2251 C  CG  . TYR A 1 355 ? 108.960 98.149  127.434 1.00 53.98  ? 355 TYR A CG  1 
ATOM   2252 C  CD1 . TYR A 1 355 ? 109.063 97.381  128.584 1.00 57.22  ? 355 TYR A CD1 1 
ATOM   2253 C  CD2 . TYR A 1 355 ? 109.731 97.793  126.337 1.00 48.33  ? 355 TYR A CD2 1 
ATOM   2254 C  CE1 . TYR A 1 355 ? 109.918 96.300  128.643 1.00 59.82  ? 355 TYR A CE1 1 
ATOM   2255 C  CE2 . TYR A 1 355 ? 110.586 96.716  126.387 1.00 51.22  ? 355 TYR A CE2 1 
ATOM   2256 C  CZ  . TYR A 1 355 ? 110.677 95.972  127.540 1.00 60.25  ? 355 TYR A CZ  1 
ATOM   2257 O  OH  . TYR A 1 355 ? 111.531 94.896  127.590 1.00 63.76  ? 355 TYR A OH  1 
ATOM   2258 N  N   . ALA A 1 356 ? 105.839 101.191 126.177 1.00 39.45  ? 356 ALA A N   1 
ATOM   2259 C  CA  . ALA A 1 356 ? 105.008 102.388 126.211 1.00 45.10  ? 356 ALA A CA  1 
ATOM   2260 C  C   . ALA A 1 356 ? 103.541 102.046 125.993 1.00 50.97  ? 356 ALA A C   1 
ATOM   2261 O  O   . ALA A 1 356 ? 102.659 102.640 126.622 1.00 54.70  ? 356 ALA A O   1 
ATOM   2262 C  CB  . ALA A 1 356 ? 105.491 103.390 125.163 1.00 43.03  ? 356 ALA A CB  1 
ATOM   2263 N  N   . GLY A 1 357 ? 103.260 101.098 125.097 1.00 41.47  ? 357 GLY A N   1 
ATOM   2264 C  CA  . GLY A 1 357 ? 101.887 100.662 124.905 1.00 43.88  ? 357 GLY A CA  1 
ATOM   2265 C  C   . GLY A 1 357 ? 101.300 100.028 126.151 1.00 45.18  ? 357 GLY A C   1 
ATOM   2266 O  O   . GLY A 1 357 ? 100.137 100.261 126.486 1.00 48.76  ? 357 GLY A O   1 
ATOM   2267 N  N   . PHE A 1 358 ? 102.095 99.214  126.849 1.00 41.65  ? 358 PHE A N   1 
ATOM   2268 C  CA  . PHE A 1 358 ? 101.659 98.641  128.118 1.00 46.22  ? 358 PHE A CA  1 
ATOM   2269 C  C   . PHE A 1 358 ? 101.262 99.736  129.098 1.00 47.52  ? 358 PHE A C   1 
ATOM   2270 O  O   . PHE A 1 358 ? 100.178 99.696  129.696 1.00 53.64  ? 358 PHE A O   1 
ATOM   2271 C  CB  . PHE A 1 358 ? 102.776 97.783  128.716 1.00 45.44  ? 358 PHE A CB  1 
ATOM   2272 C  CG  . PHE A 1 358 ? 102.624 96.313  128.461 1.00 52.45  ? 358 PHE A CG  1 
ATOM   2273 C  CD1 . PHE A 1 358 ? 101.783 95.545  129.247 1.00 53.80  ? 358 PHE A CD1 1 
ATOM   2274 C  CD2 . PHE A 1 358 ? 103.336 95.694  127.449 1.00 49.79  ? 358 PHE A CD2 1 
ATOM   2275 C  CE1 . PHE A 1 358 ? 101.646 94.192  129.019 1.00 52.26  ? 358 PHE A CE1 1 
ATOM   2276 C  CE2 . PHE A 1 358 ? 103.202 94.339  127.217 1.00 49.73  ? 358 PHE A CE2 1 
ATOM   2277 C  CZ  . PHE A 1 358 ? 102.357 93.588  128.003 1.00 47.57  ? 358 PHE A CZ  1 
ATOM   2278 N  N   . VAL A 1 359 ? 102.137 100.730 129.267 1.00 48.72  ? 359 VAL A N   1 
ATOM   2279 C  CA  . VAL A 1 359 ? 101.860 101.809 130.217 1.00 46.58  ? 359 VAL A CA  1 
ATOM   2280 C  C   . VAL A 1 359 ? 100.597 102.567 129.812 1.00 48.86  ? 359 VAL A C   1 
ATOM   2281 O  O   . VAL A 1 359 ? 99.705  102.820 130.636 1.00 61.16  ? 359 VAL A O   1 
ATOM   2282 C  CB  . VAL A 1 359 ? 103.073 102.751 130.324 1.00 55.21  ? 359 VAL A CB  1 
ATOM   2283 C  CG1 . VAL A 1 359 ? 102.743 103.944 131.203 1.00 50.84  ? 359 VAL A CG1 1 
ATOM   2284 C  CG2 . VAL A 1 359 ? 104.282 102.004 130.859 1.00 53.20  ? 359 VAL A CG2 1 
ATOM   2285 N  N   . ILE A 1 360 ? 100.496 102.918 128.528 1.00 46.49  ? 360 ILE A N   1 
ATOM   2286 C  CA  . ILE A 1 360 ? 99.375  103.718 128.048 1.00 39.74  ? 360 ILE A CA  1 
ATOM   2287 C  C   . ILE A 1 360 ? 98.062  102.970 128.229 1.00 43.72  ? 360 ILE A C   1 
ATOM   2288 O  O   . ILE A 1 360 ? 97.059  103.549 128.657 1.00 49.41  ? 360 ILE A O   1 
ATOM   2289 C  CB  . ILE A 1 360 ? 99.604  104.121 126.579 1.00 46.05  ? 360 ILE A CB  1 
ATOM   2290 C  CG1 . ILE A 1 360 ? 100.480 105.372 126.498 1.00 53.72  ? 360 ILE A CG1 1 
ATOM   2291 C  CG2 . ILE A 1 360 ? 98.280  104.342 125.862 1.00 48.06  ? 360 ILE A CG2 1 
ATOM   2292 C  CD1 . ILE A 1 360 ? 99.718  106.669 126.634 1.00 48.07  ? 360 ILE A CD1 1 
ATOM   2293 N  N   . PHE A 1 361 ? 98.041  101.673 127.914 1.00 51.13  ? 361 PHE A N   1 
ATOM   2294 C  CA  . PHE A 1 361 ? 96.791  100.932 128.008 1.00 46.42  ? 361 PHE A CA  1 
ATOM   2295 C  C   . PHE A 1 361 ? 96.417  100.629 129.452 1.00 49.27  ? 361 PHE A C   1 
ATOM   2296 O  O   . PHE A 1 361 ? 95.226  100.546 129.769 1.00 60.58  ? 361 PHE A O   1 
ATOM   2297 C  CB  . PHE A 1 361 ? 96.873  99.655  127.176 1.00 41.98  ? 361 PHE A CB  1 
ATOM   2298 C  CG  . PHE A 1 361 ? 96.438  99.845  125.753 1.00 47.84  ? 361 PHE A CG  1 
ATOM   2299 C  CD1 . PHE A 1 361 ? 97.297  100.401 124.821 1.00 50.04  ? 361 PHE A CD1 1 
ATOM   2300 C  CD2 . PHE A 1 361 ? 95.163  99.491  125.351 1.00 52.18  ? 361 PHE A CD2 1 
ATOM   2301 C  CE1 . PHE A 1 361 ? 96.898  100.588 123.514 1.00 46.97  ? 361 PHE A CE1 1 
ATOM   2302 C  CE2 . PHE A 1 361 ? 94.758  99.675  124.044 1.00 54.41  ? 361 PHE A CE2 1 
ATOM   2303 C  CZ  . PHE A 1 361 ? 95.627  100.224 123.125 1.00 47.86  ? 361 PHE A CZ  1 
ATOM   2304 N  N   . SER A 1 362 ? 97.399  100.490 130.347 1.00 49.11  ? 362 SER A N   1 
ATOM   2305 C  CA  . SER A 1 362 ? 97.064  100.417 131.766 1.00 48.07  ? 362 SER A CA  1 
ATOM   2306 C  C   . SER A 1 362 ? 96.393  101.705 132.233 1.00 55.98  ? 362 SER A C   1 
ATOM   2307 O  O   . SER A 1 362 ? 95.376  101.668 132.943 1.00 57.82  ? 362 SER A O   1 
ATOM   2308 C  CB  . SER A 1 362 ? 98.319  100.137 132.590 1.00 50.71  ? 362 SER A CB  1 
ATOM   2309 O  OG  . SER A 1 362 ? 99.004  99.000  132.101 1.00 66.00  ? 362 SER A OG  1 
ATOM   2310 N  N   . ILE A 1 363 ? 96.939  102.855 131.825 1.00 60.67  ? 363 ILE A N   1 
ATOM   2311 C  CA  . ILE A 1 363 ? 96.319  104.130 132.184 1.00 53.67  ? 363 ILE A CA  1 
ATOM   2312 C  C   . ILE A 1 363 ? 94.914  104.226 131.600 1.00 54.25  ? 363 ILE A C   1 
ATOM   2313 O  O   . ILE A 1 363 ? 93.983  104.704 132.259 1.00 59.60  ? 363 ILE A O   1 
ATOM   2314 C  CB  . ILE A 1 363 ? 97.198  105.309 131.728 1.00 50.40  ? 363 ILE A CB  1 
ATOM   2315 C  CG1 . ILE A 1 363 ? 98.594  105.210 132.339 1.00 52.64  ? 363 ILE A CG1 1 
ATOM   2316 C  CG2 . ILE A 1 363 ? 96.554  106.629 132.109 1.00 52.78  ? 363 ILE A CG2 1 
ATOM   2317 C  CD1 . ILE A 1 363 ? 99.644  105.970 131.559 1.00 54.29  ? 363 ILE A CD1 1 
ATOM   2318 N  N   . LEU A 1 364 ? 94.742  103.788 130.350 1.00 53.29  ? 364 LEU A N   1 
ATOM   2319 C  CA  . LEU A 1 364 ? 93.434  103.860 129.705 1.00 47.90  ? 364 LEU A CA  1 
ATOM   2320 C  C   . LEU A 1 364 ? 92.414  102.981 130.415 1.00 53.39  ? 364 LEU A C   1 
ATOM   2321 O  O   . LEU A 1 364 ? 91.258  103.379 130.590 1.00 57.33  ? 364 LEU A O   1 
ATOM   2322 C  CB  . LEU A 1 364 ? 93.548  103.461 128.234 1.00 47.14  ? 364 LEU A CB  1 
ATOM   2323 C  CG  . LEU A 1 364 ? 93.966  104.549 127.244 1.00 49.22  ? 364 LEU A CG  1 
ATOM   2324 C  CD1 . LEU A 1 364 ? 94.219  103.951 125.872 1.00 46.15  ? 364 LEU A CD1 1 
ATOM   2325 C  CD2 . LEU A 1 364 ? 92.912  105.636 127.167 1.00 55.85  ? 364 LEU A CD2 1 
ATOM   2326 N  N   . GLY A 1 365 ? 92.819  101.775 130.820 1.00 63.42  ? 365 GLY A N   1 
ATOM   2327 C  CA  . GLY A 1 365 ? 91.915  100.919 131.570 1.00 54.51  ? 365 GLY A CA  1 
ATOM   2328 C  C   . GLY A 1 365 ? 91.520  101.522 132.904 1.00 62.42  ? 365 GLY A C   1 
ATOM   2329 O  O   . GLY A 1 365 ? 90.346  101.490 133.288 1.00 71.49  ? 365 GLY A O   1 
ATOM   2330 N  N   . PHE A 1 366 ? 92.491  102.095 133.622 1.00 66.65  ? 366 PHE A N   1 
ATOM   2331 C  CA  . PHE A 1 366 ? 92.166  102.749 134.887 1.00 64.63  ? 366 PHE A CA  1 
ATOM   2332 C  C   . PHE A 1 366 ? 91.208  103.916 134.675 1.00 64.73  ? 366 PHE A C   1 
ATOM   2333 O  O   . PHE A 1 366 ? 90.266  104.104 135.453 1.00 61.72  ? 366 PHE A O   1 
ATOM   2334 C  CB  . PHE A 1 366 ? 93.441  103.224 135.583 1.00 70.34  ? 366 PHE A CB  1 
ATOM   2335 C  CG  . PHE A 1 366 ? 93.219  104.359 136.543 1.00 72.54  ? 366 PHE A CG  1 
ATOM   2336 C  CD1 . PHE A 1 366 ? 92.652  104.131 137.785 1.00 69.02  ? 366 PHE A CD1 1 
ATOM   2337 C  CD2 . PHE A 1 366 ? 93.582  105.653 136.206 1.00 68.29  ? 366 PHE A CD2 1 
ATOM   2338 C  CE1 . PHE A 1 366 ? 92.446  105.169 138.671 1.00 67.37  ? 366 PHE A CE1 1 
ATOM   2339 C  CE2 . PHE A 1 366 ? 93.378  106.696 137.088 1.00 69.89  ? 366 PHE A CE2 1 
ATOM   2340 C  CZ  . PHE A 1 366 ? 92.809  106.453 138.322 1.00 70.56  ? 366 PHE A CZ  1 
ATOM   2341 N  N   . MET A 1 367 ? 91.436  104.712 133.627 1.00 71.64  ? 367 MET A N   1 
ATOM   2342 C  CA  . MET A 1 367 ? 90.564  105.850 133.349 1.00 67.69  ? 367 MET A CA  1 
ATOM   2343 C  C   . MET A 1 367 ? 89.154  105.396 132.992 1.00 69.90  ? 367 MET A C   1 
ATOM   2344 O  O   . MET A 1 367 ? 88.169  105.987 133.448 1.00 73.48  ? 367 MET A O   1 
ATOM   2345 C  CB  . MET A 1 367 ? 91.154  106.694 132.220 1.00 66.35  ? 367 MET A CB  1 
ATOM   2346 C  CG  . MET A 1 367 ? 91.834  107.968 132.686 1.00 74.84  ? 367 MET A CG  1 
ATOM   2347 S  SD  . MET A 1 367 ? 92.668  108.859 131.357 1.00 88.63  ? 367 MET A SD  1 
ATOM   2348 C  CE  . MET A 1 367 ? 91.794  108.245 129.921 1.00 72.05  ? 367 MET A CE  1 
ATOM   2349 N  N   . ALA A 1 368 ? 89.037  104.349 132.173 1.00 74.35  ? 368 ALA A N   1 
ATOM   2350 C  CA  . ALA A 1 368 ? 87.725  103.846 131.787 1.00 70.67  ? 368 ALA A CA  1 
ATOM   2351 C  C   . ALA A 1 368 ? 86.995  103.188 132.947 1.00 70.00  ? 368 ALA A C   1 
ATOM   2352 O  O   . ALA A 1 368 ? 85.761  103.127 132.931 1.00 71.71  ? 368 ALA A O   1 
ATOM   2353 C  CB  . ALA A 1 368 ? 87.860  102.855 130.631 1.00 69.38  ? 368 ALA A CB  1 
ATOM   2354 N  N   . ASN A 1 369 ? 87.723  102.683 133.945 1.00 75.07  ? 369 ASN A N   1 
ATOM   2355 C  CA  . ASN A 1 369 ? 87.060  102.082 135.096 1.00 75.62  ? 369 ASN A CA  1 
ATOM   2356 C  C   . ASN A 1 369 ? 86.230  103.088 135.885 1.00 81.08  ? 369 ASN A C   1 
ATOM   2357 O  O   . ASN A 1 369 ? 85.123  102.758 136.322 1.00 83.05  ? 369 ASN A O   1 
ATOM   2358 C  CB  . ASN A 1 369 ? 88.086  101.426 136.018 1.00 80.28  ? 369 ASN A CB  1 
ATOM   2359 C  CG  . ASN A 1 369 ? 87.452  100.823 137.256 1.00 83.78  ? 369 ASN A CG  1 
ATOM   2360 O  OD1 . ASN A 1 369 ? 87.529  101.389 138.346 1.00 86.38  ? 369 ASN A OD1 1 
ATOM   2361 N  ND2 . ASN A 1 369 ? 86.815  99.670  137.092 1.00 80.62  ? 369 ASN A ND2 1 
ATOM   2362 N  N   . HIS A 1 370 ? 86.737  104.307 136.083 1.00 83.61  ? 370 HIS A N   1 
ATOM   2363 C  CA  . HIS A 1 370 ? 86.049  105.293 136.905 1.00 82.24  ? 370 HIS A CA  1 
ATOM   2364 C  C   . HIS A 1 370 ? 85.188  106.270 136.117 1.00 83.28  ? 370 HIS A C   1 
ATOM   2365 O  O   . HIS A 1 370 ? 84.462  107.056 136.734 1.00 84.45  ? 370 HIS A O   1 
ATOM   2366 C  CB  . HIS A 1 370 ? 87.062  106.076 137.758 1.00 83.27  ? 370 HIS A CB  1 
ATOM   2367 C  CG  . HIS A 1 370 ? 87.574  107.328 137.114 1.00 83.45  ? 370 HIS A CG  1 
ATOM   2368 N  ND1 . HIS A 1 370 ? 88.754  107.370 136.403 1.00 84.66  ? 370 HIS A ND1 1 
ATOM   2369 C  CD2 . HIS A 1 370 ? 87.089  108.593 137.110 1.00 84.69  ? 370 HIS A CD2 1 
ATOM   2370 C  CE1 . HIS A 1 370 ? 88.961  108.599 135.967 1.00 84.08  ? 370 HIS A CE1 1 
ATOM   2371 N  NE2 . HIS A 1 370 ? 87.965  109.361 136.382 1.00 86.46  ? 370 HIS A NE2 1 
ATOM   2372 N  N   . LEU A 1 371 ? 85.241  106.243 134.787 1.00 82.18  ? 371 LEU A N   1 
ATOM   2373 C  CA  . LEU A 1 371 ? 84.368  107.081 133.973 1.00 81.77  ? 371 LEU A CA  1 
ATOM   2374 C  C   . LEU A 1 371 ? 83.077  106.381 133.572 1.00 83.89  ? 371 LEU A C   1 
ATOM   2375 O  O   . LEU A 1 371 ? 82.227  107.007 132.930 1.00 85.18  ? 371 LEU A O   1 
ATOM   2376 C  CB  . LEU A 1 371 ? 85.107  107.556 132.718 1.00 81.55  ? 371 LEU A CB  1 
ATOM   2377 C  CG  . LEU A 1 371 ? 86.045  108.752 132.894 1.00 80.85  ? 371 LEU A CG  1 
ATOM   2378 C  CD1 . LEU A 1 371 ? 86.830  109.015 131.619 1.00 80.18  ? 371 LEU A CD1 1 
ATOM   2379 C  CD2 . LEU A 1 371 ? 85.263  109.986 133.307 1.00 81.04  ? 371 LEU A CD2 1 
ATOM   2380 N  N   . GLY A 1 372 ? 82.908  105.113 133.933 1.00 82.38  ? 372 GLY A N   1 
ATOM   2381 C  CA  . GLY A 1 372 ? 81.701  104.375 133.599 1.00 80.11  ? 372 GLY A CA  1 
ATOM   2382 C  C   . GLY A 1 372 ? 81.499  104.124 132.121 1.00 84.09  ? 372 GLY A C   1 
ATOM   2383 O  O   . GLY A 1 372 ? 80.356  104.119 131.648 1.00 88.67  ? 372 GLY A O   1 
ATOM   2384 N  N   . VAL A 1 373 ? 82.582  103.911 131.376 1.00 77.84  ? 373 VAL A N   1 
ATOM   2385 C  CA  . VAL A 1 373 ? 82.538  103.635 129.947 1.00 74.31  ? 373 VAL A CA  1 
ATOM   2386 C  C   . VAL A 1 373 ? 83.396  102.405 129.668 1.00 81.22  ? 373 VAL A C   1 
ATOM   2387 O  O   . VAL A 1 373 ? 83.963  101.797 130.579 1.00 83.72  ? 373 VAL A O   1 
ATOM   2388 C  CB  . VAL A 1 373 ? 83.012  104.837 129.101 1.00 77.36  ? 373 VAL A CB  1 
ATOM   2389 C  CG1 . VAL A 1 373 ? 82.314  106.113 129.540 1.00 78.87  ? 373 VAL A CG1 1 
ATOM   2390 C  CG2 . VAL A 1 373 ? 84.517  105.002 129.207 1.00 79.35  ? 373 VAL A CG2 1 
ATOM   2391 N  N   . ASP A 1 374 ? 83.482  102.035 128.395 1.00 83.09  ? 374 ASP A N   1 
ATOM   2392 C  CA  . ASP A 1 374 ? 84.316  100.930 127.950 1.00 76.38  ? 374 ASP A CA  1 
ATOM   2393 C  C   . ASP A 1 374 ? 85.694  101.436 127.539 1.00 76.47  ? 374 ASP A C   1 
ATOM   2394 O  O   . ASP A 1 374 ? 85.893  102.624 127.274 1.00 83.98  ? 374 ASP A O   1 
ATOM   2395 C  CB  . ASP A 1 374 ? 83.661  100.188 126.783 1.00 77.77  ? 374 ASP A CB  1 
ATOM   2396 C  CG  . ASP A 1 374 ? 83.992  98.711  126.775 1.00 84.45  ? 374 ASP A CG  1 
ATOM   2397 O  OD1 . ASP A 1 374 ? 84.009  98.099  127.863 1.00 86.74  ? 374 ASP A OD1 1 
ATOM   2398 O  OD2 . ASP A 1 374 ? 84.237  98.161  125.681 1.00 84.92  ? 374 ASP A OD2 1 
ATOM   2399 N  N   . VAL A 1 375 ? 86.653  100.509 127.492 1.00 64.70  ? 375 VAL A N   1 
ATOM   2400 C  CA  . VAL A 1 375 ? 88.023  100.870 127.142 1.00 65.00  ? 375 VAL A CA  1 
ATOM   2401 C  C   . VAL A 1 375 ? 88.111  101.346 125.699 1.00 64.64  ? 375 VAL A C   1 
ATOM   2402 O  O   . VAL A 1 375 ? 88.972  102.166 125.359 1.00 66.83  ? 375 VAL A O   1 
ATOM   2403 C  CB  . VAL A 1 375 ? 88.971  99.684  127.402 1.00 64.29  ? 375 VAL A CB  1 
ATOM   2404 C  CG1 . VAL A 1 375 ? 90.403  100.172 127.537 1.00 62.26  ? 375 VAL A CG1 1 
ATOM   2405 C  CG2 . VAL A 1 375 ? 88.540  98.930  128.646 1.00 63.05  ? 375 VAL A CG2 1 
ATOM   2406 N  N   . SER A 1 376 ? 87.235  100.846 124.829 1.00 60.16  ? 376 SER A N   1 
ATOM   2407 C  CA  . SER A 1 376 ? 87.256  101.230 123.425 1.00 64.25  ? 376 SER A CA  1 
ATOM   2408 C  C   . SER A 1 376 ? 86.572  102.564 123.157 1.00 68.83  ? 376 SER A C   1 
ATOM   2409 O  O   . SER A 1 376 ? 86.645  103.060 122.028 1.00 70.39  ? 376 SER A O   1 
ATOM   2410 C  CB  . SER A 1 376 ? 86.600  100.140 122.573 1.00 68.96  ? 376 SER A CB  1 
ATOM   2411 O  OG  . SER A 1 376 ? 85.439  99.630  123.202 1.00 70.02  ? 376 SER A OG  1 
ATOM   2412 N  N   . ARG A 1 377 ? 85.918  103.156 124.157 1.00 80.78  ? 377 ARG A N   1 
ATOM   2413 C  CA  . ARG A 1 377 ? 85.198  104.409 123.982 1.00 76.94  ? 377 ARG A CA  1 
ATOM   2414 C  C   . ARG A 1 377 ? 85.632  105.501 124.949 1.00 80.51  ? 377 ARG A C   1 
ATOM   2415 O  O   . ARG A 1 377 ? 85.008  106.569 124.969 1.00 82.76  ? 377 ARG A O   1 
ATOM   2416 C  CB  . ARG A 1 377 ? 83.688  104.178 124.130 1.00 72.78  ? 377 ARG A CB  1 
ATOM   2417 C  CG  . ARG A 1 377 ? 83.097  103.237 123.098 1.00 77.96  ? 377 ARG A CG  1 
ATOM   2418 C  CD  . ARG A 1 377 ? 81.640  103.570 122.819 1.00 83.39  ? 377 ARG A CD  1 
ATOM   2419 N  NE  . ARG A 1 377 ? 80.946  104.052 124.008 1.00 87.47  ? 377 ARG A NE  1 
ATOM   2420 C  CZ  . ARG A 1 377 ? 80.479  103.271 124.973 1.00 87.73  ? 377 ARG A CZ  1 
ATOM   2421 N  NH1 . ARG A 1 377 ? 80.608  101.956 124.922 1.00 82.48  ? 377 ARG A NH1 1 
ATOM   2422 N  NH2 . ARG A 1 377 ? 79.866  103.825 126.016 1.00 84.74  ? 377 ARG A NH2 1 
ATOM   2423 N  N   . VAL A 1 378 ? 86.673  105.271 125.751 1.00 71.60  ? 378 VAL A N   1 
ATOM   2424 C  CA  . VAL A 1 378 ? 87.067  106.253 126.757 1.00 69.91  ? 378 VAL A CA  1 
ATOM   2425 C  C   . VAL A 1 378 ? 87.647  107.503 126.100 1.00 70.95  ? 378 VAL A C   1 
ATOM   2426 O  O   . VAL A 1 378 ? 87.411  108.626 126.561 1.00 78.02  ? 378 VAL A O   1 
ATOM   2427 C  CB  . VAL A 1 378 ? 88.046  105.618 127.764 1.00 66.19  ? 378 VAL A CB  1 
ATOM   2428 C  CG1 . VAL A 1 378 ? 89.251  105.028 127.052 1.00 70.30  ? 378 VAL A CG1 1 
ATOM   2429 C  CG2 . VAL A 1 378 ? 88.480  106.636 128.804 1.00 70.63  ? 378 VAL A CG2 1 
ATOM   2430 N  N   . ALA A 1 379 ? 88.399  107.338 125.016 1.00 63.23  ? 379 ALA A N   1 
ATOM   2431 C  CA  . ALA A 1 379 ? 89.046  108.451 124.338 1.00 66.89  ? 379 ALA A CA  1 
ATOM   2432 C  C   . ALA A 1 379 ? 88.694  108.425 122.857 1.00 69.42  ? 379 ALA A C   1 
ATOM   2433 O  O   . ALA A 1 379 ? 88.175  107.437 122.334 1.00 78.57  ? 379 ALA A O   1 
ATOM   2434 C  CB  . ALA A 1 379 ? 90.569  108.410 124.525 1.00 63.25  ? 379 ALA A CB  1 
ATOM   2435 N  N   . ASP A 1 380 ? 88.981  109.533 122.181 1.00 70.37  ? 380 ASP A N   1 
ATOM   2436 C  CA  . ASP A 1 380 ? 88.764  109.649 120.748 1.00 72.57  ? 380 ASP A CA  1 
ATOM   2437 C  C   . ASP A 1 380 ? 90.023  109.241 119.991 1.00 72.94  ? 380 ASP A C   1 
ATOM   2438 O  O   . ASP A 1 380 ? 91.098  109.060 120.566 1.00 76.78  ? 380 ASP A O   1 
ATOM   2439 C  CB  . ASP A 1 380 ? 88.343  111.074 120.374 1.00 75.23  ? 380 ASP A CB  1 
ATOM   2440 C  CG  . ASP A 1 380 ? 89.232  112.131 120.998 1.00 83.06  ? 380 ASP A CG  1 
ATOM   2441 O  OD1 . ASP A 1 380 ? 89.200  112.280 122.238 1.00 83.94  ? 380 ASP A OD1 1 
ATOM   2442 O  OD2 . ASP A 1 380 ? 89.956  112.818 120.248 1.00 84.96  ? 380 ASP A OD2 1 
ATOM   2443 N  N   . HIS A 1 381 ? 89.877  109.105 118.672 1.00 65.82  ? 381 HIS A N   1 
ATOM   2444 C  CA  . HIS A 1 381 ? 90.930  108.573 117.815 1.00 67.35  ? 381 HIS A CA  1 
ATOM   2445 C  C   . HIS A 1 381 ? 91.858  109.654 117.273 1.00 68.73  ? 381 HIS A C   1 
ATOM   2446 O  O   . HIS A 1 381 ? 92.449  109.475 116.199 1.00 70.46  ? 381 HIS A O   1 
ATOM   2447 C  CB  . HIS A 1 381 ? 90.312  107.775 116.666 1.00 67.65  ? 381 HIS A CB  1 
ATOM   2448 C  CG  . HIS A 1 381 ? 89.504  106.597 117.113 1.00 71.81  ? 381 HIS A CG  1 
ATOM   2449 N  ND1 . HIS A 1 381 ? 88.750  105.839 116.243 1.00 68.25  ? 381 HIS A ND1 1 
ATOM   2450 C  CD2 . HIS A 1 381 ? 89.332  106.045 118.337 1.00 67.42  ? 381 HIS A CD2 1 
ATOM   2451 C  CE1 . HIS A 1 381 ? 88.148  104.872 116.912 1.00 69.87  ? 381 HIS A CE1 1 
ATOM   2452 N  NE2 . HIS A 1 381 ? 88.484  104.975 118.185 1.00 69.36  ? 381 HIS A NE2 1 
ATOM   2453 N  N   . GLY A 1 382 ? 92.006  110.768 117.983 1.00 59.37  ? 382 GLY A N   1 
ATOM   2454 C  CA  . GLY A 1 382 ? 92.880  111.833 117.554 1.00 53.14  ? 382 GLY A CA  1 
ATOM   2455 C  C   . GLY A 1 382 ? 94.332  111.563 117.890 1.00 55.65  ? 382 GLY A C   1 
ATOM   2456 O  O   . GLY A 1 382 ? 94.663  110.609 118.601 1.00 57.90  ? 382 GLY A O   1 
ATOM   2457 N  N   . PRO A 1 383 ? 95.234  112.406 117.380 1.00 58.87  ? 383 PRO A N   1 
ATOM   2458 C  CA  . PRO A 1 383 ? 96.667  112.207 117.649 1.00 58.02  ? 383 PRO A CA  1 
ATOM   2459 C  C   . PRO A 1 383 ? 97.102  112.629 119.043 1.00 52.61  ? 383 PRO A C   1 
ATOM   2460 O  O   . PRO A 1 383 ? 98.231  112.308 119.436 1.00 59.26  ? 383 PRO A O   1 
ATOM   2461 C  CB  . PRO A 1 383 ? 97.344  113.067 116.577 1.00 50.47  ? 383 PRO A CB  1 
ATOM   2462 C  CG  . PRO A 1 383 ? 96.360  114.147 116.303 1.00 48.71  ? 383 PRO A CG  1 
ATOM   2463 C  CD  . PRO A 1 383 ? 94.997  113.525 116.451 1.00 57.53  ? 383 PRO A CD  1 
ATOM   2464 N  N   . GLY A 1 384 ? 96.261  113.328 119.798 1.00 45.85  ? 384 GLY A N   1 
ATOM   2465 C  CA  . GLY A 1 384 ? 96.645  113.790 121.117 1.00 42.75  ? 384 GLY A CA  1 
ATOM   2466 C  C   . GLY A 1 384 ? 96.285  112.831 122.233 1.00 51.02  ? 384 GLY A C   1 
ATOM   2467 O  O   . GLY A 1 384 ? 95.832  113.257 123.299 1.00 53.28  ? 384 GLY A O   1 
ATOM   2468 N  N   . LEU A 1 385 ? 96.479  111.531 122.000 1.00 55.70  ? 385 LEU A N   1 
ATOM   2469 C  CA  . LEU A 1 385 ? 96.176  110.543 123.031 1.00 50.39  ? 385 LEU A CA  1 
ATOM   2470 C  C   . LEU A 1 385 ? 97.213  110.568 124.147 1.00 52.79  ? 385 LEU A C   1 
ATOM   2471 O  O   . LEU A 1 385 ? 96.863  110.467 125.329 1.00 47.05  ? 385 LEU A O   1 
ATOM   2472 C  CB  . LEU A 1 385 ? 96.089  109.148 122.411 1.00 49.51  ? 385 LEU A CB  1 
ATOM   2473 C  CG  . LEU A 1 385 ? 95.718  107.996 123.349 1.00 50.22  ? 385 LEU A CG  1 
ATOM   2474 C  CD1 . LEU A 1 385 ? 94.270  108.103 123.791 1.00 46.36  ? 385 LEU A CD1 1 
ATOM   2475 C  CD2 . LEU A 1 385 ? 95.978  106.655 122.688 1.00 45.48  ? 385 LEU A CD2 1 
ATOM   2476 N  N   . ALA A 1 386 ? 98.493  110.697 123.793 1.00 58.97  ? 386 ALA A N   1 
ATOM   2477 C  CA  . ALA A 1 386 ? 99.552  110.725 124.796 1.00 52.14  ? 386 ALA A CA  1 
ATOM   2478 C  C   . ALA A 1 386 ? 99.456  111.937 125.712 1.00 52.00  ? 386 ALA A C   1 
ATOM   2479 O  O   . ALA A 1 386 ? 99.604  111.790 126.930 1.00 59.26  ? 386 ALA A O   1 
ATOM   2480 C  CB  . ALA A 1 386 ? 100.921 110.694 124.115 1.00 47.10  ? 386 ALA A CB  1 
ATOM   2481 N  N   . PHE A 1 387 ? 99.188  113.119 125.161 1.00 51.18  ? 387 PHE A N   1 
ATOM   2482 C  CA  . PHE A 1 387 ? 99.095  114.348 125.937 1.00 49.89  ? 387 PHE A CA  1 
ATOM   2483 C  C   . PHE A 1 387 ? 97.863  114.392 126.829 1.00 52.05  ? 387 PHE A C   1 
ATOM   2484 O  O   . PHE A 1 387 ? 97.738  115.309 127.645 1.00 58.87  ? 387 PHE A O   1 
ATOM   2485 C  CB  . PHE A 1 387 ? 99.106  115.562 125.003 1.00 41.87  ? 387 PHE A CB  1 
ATOM   2486 C  CG  . PHE A 1 387 ? 100.410 115.756 124.283 1.00 51.58  ? 387 PHE A CG  1 
ATOM   2487 C  CD1 . PHE A 1 387 ? 101.512 116.268 124.946 1.00 47.57  ? 387 PHE A CD1 1 
ATOM   2488 C  CD2 . PHE A 1 387 ? 100.535 115.421 122.946 1.00 53.47  ? 387 PHE A CD2 1 
ATOM   2489 C  CE1 . PHE A 1 387 ? 102.713 116.445 124.289 1.00 46.90  ? 387 PHE A CE1 1 
ATOM   2490 C  CE2 . PHE A 1 387 ? 101.735 115.596 122.284 1.00 48.37  ? 387 PHE A CE2 1 
ATOM   2491 C  CZ  . PHE A 1 387 ? 102.824 116.108 122.957 1.00 44.25  ? 387 PHE A CZ  1 
ATOM   2492 N  N   . VAL A 1 388 ? 96.949  113.433 126.683 1.00 54.88  ? 388 VAL A N   1 
ATOM   2493 C  CA  . VAL A 1 388 ? 95.817  113.275 127.583 1.00 52.81  ? 388 VAL A CA  1 
ATOM   2494 C  C   . VAL A 1 388 ? 96.050  112.154 128.588 1.00 53.84  ? 388 VAL A C   1 
ATOM   2495 O  O   . VAL A 1 388 ? 95.666  112.272 129.758 1.00 57.57  ? 388 VAL A O   1 
ATOM   2496 C  CB  . VAL A 1 388 ? 94.513  113.033 126.790 1.00 53.78  ? 388 VAL A CB  1 
ATOM   2497 C  CG1 . VAL A 1 388 ? 93.382  112.612 127.712 1.00 51.81  ? 388 VAL A CG1 1 
ATOM   2498 C  CG2 . VAL A 1 388 ? 94.128  114.278 126.009 1.00 50.24  ? 388 VAL A CG2 1 
ATOM   2499 N  N   . ALA A 1 389 ? 96.704  111.070 128.165 1.00 53.62  ? 389 ALA A N   1 
ATOM   2500 C  CA  . ALA A 1 389 ? 96.868  109.907 129.031 1.00 55.13  ? 389 ALA A CA  1 
ATOM   2501 C  C   . ALA A 1 389 ? 98.030  110.074 130.004 1.00 56.08  ? 389 ALA A C   1 
ATOM   2502 O  O   . ALA A 1 389 ? 97.871  109.850 131.208 1.00 61.64  ? 389 ALA A O   1 
ATOM   2503 C  CB  . ALA A 1 389 ? 97.058  108.648 128.185 1.00 54.00  ? 389 ALA A CB  1 
ATOM   2504 N  N   . TYR A 1 390 ? 99.210  110.449 129.503 1.00 56.51  ? 390 TYR A N   1 
ATOM   2505 C  CA  . TYR A 1 390 ? 100.385 110.538 130.370 1.00 51.72  ? 390 TYR A CA  1 
ATOM   2506 C  C   . TYR A 1 390 ? 100.224 111.538 131.509 1.00 57.38  ? 390 TYR A C   1 
ATOM   2507 O  O   . TYR A 1 390 ? 100.630 111.215 132.639 1.00 63.05  ? 390 TYR A O   1 
ATOM   2508 C  CB  . TYR A 1 390 ? 101.626 110.849 129.526 1.00 53.53  ? 390 TYR A CB  1 
ATOM   2509 C  CG  . TYR A 1 390 ? 102.184 109.653 128.791 1.00 54.86  ? 390 TYR A CG  1 
ATOM   2510 C  CD1 . TYR A 1 390 ? 102.434 108.461 129.455 1.00 55.55  ? 390 TYR A CD1 1 
ATOM   2511 C  CD2 . TYR A 1 390 ? 102.468 109.718 127.435 1.00 56.85  ? 390 TYR A CD2 1 
ATOM   2512 C  CE1 . TYR A 1 390 ? 102.946 107.366 128.787 1.00 58.16  ? 390 TYR A CE1 1 
ATOM   2513 C  CE2 . TYR A 1 390 ? 102.981 108.630 126.760 1.00 54.79  ? 390 TYR A CE2 1 
ATOM   2514 C  CZ  . TYR A 1 390 ? 103.217 107.457 127.441 1.00 55.14  ? 390 TYR A CZ  1 
ATOM   2515 O  OH  . TYR A 1 390 ? 103.728 106.372 126.769 1.00 59.80  ? 390 TYR A OH  1 
ATOM   2516 N  N   . PRO A 1 391 ? 99.690  112.751 131.303 1.00 55.40  ? 391 PRO A N   1 
ATOM   2517 C  CA  . PRO A 1 391 ? 99.490  113.649 132.455 1.00 55.38  ? 391 PRO A CA  1 
ATOM   2518 C  C   . PRO A 1 391 ? 98.596  113.069 133.539 1.00 55.24  ? 391 PRO A C   1 
ATOM   2519 O  O   . PRO A 1 391 ? 98.821  113.336 134.727 1.00 62.56  ? 391 PRO A O   1 
ATOM   2520 C  CB  . PRO A 1 391 ? 98.874  114.896 131.810 1.00 54.08  ? 391 PRO A CB  1 
ATOM   2521 C  CG  . PRO A 1 391 ? 99.415  114.895 130.437 1.00 46.01  ? 391 PRO A CG  1 
ATOM   2522 C  CD  . PRO A 1 391 ? 99.436  113.454 130.031 1.00 46.78  ? 391 PRO A CD  1 
ATOM   2523 N  N   . GLU A 1 392 ? 97.586  112.280 133.166 1.00 58.95  ? 392 GLU A N   1 
ATOM   2524 C  CA  . GLU A 1 392 ? 96.726  111.657 134.169 1.00 60.07  ? 392 GLU A CA  1 
ATOM   2525 C  C   . GLU A 1 392 ? 97.516  110.706 135.060 1.00 66.93  ? 392 GLU A C   1 
ATOM   2526 O  O   . GLU A 1 392 ? 97.301  110.661 136.277 1.00 68.17  ? 392 GLU A O   1 
ATOM   2527 C  CB  . GLU A 1 392 ? 95.570  110.925 133.489 1.00 60.02  ? 392 GLU A CB  1 
ATOM   2528 C  CG  . GLU A 1 392 ? 94.314  110.824 134.340 1.00 69.36  ? 392 GLU A CG  1 
ATOM   2529 C  CD  . GLU A 1 392 ? 93.292  111.894 134.009 1.00 76.00  ? 392 GLU A CD  1 
ATOM   2530 O  OE1 . GLU A 1 392 ? 92.096  111.688 134.304 1.00 74.48  ? 392 GLU A OE1 1 
ATOM   2531 O  OE2 . GLU A 1 392 ? 93.684  112.943 133.461 1.00 71.32  ? 392 GLU A OE2 1 
ATOM   2532 N  N   . ALA A 1 393 ? 98.426  109.928 134.470 1.00 63.64  ? 393 ALA A N   1 
ATOM   2533 C  CA  . ALA A 1 393 ? 99.296  109.074 135.271 1.00 60.44  ? 393 ALA A CA  1 
ATOM   2534 C  C   . ALA A 1 393 ? 100.267 109.900 136.105 1.00 63.61  ? 393 ALA A C   1 
ATOM   2535 O  O   . ALA A 1 393 ? 100.542 109.562 137.262 1.00 63.41  ? 393 ALA A O   1 
ATOM   2536 C  CB  . ALA A 1 393 ? 100.058 108.106 134.371 1.00 57.89  ? 393 ALA A CB  1 
ATOM   2537 N  N   . LEU A 1 394 ? 100.800 110.983 135.533 1.00 61.92  ? 394 LEU A N   1 
ATOM   2538 C  CA  . LEU A 1 394 ? 101.745 111.824 136.258 1.00 61.84  ? 394 LEU A CA  1 
ATOM   2539 C  C   . LEU A 1 394 ? 101.107 112.508 137.457 1.00 62.26  ? 394 LEU A C   1 
ATOM   2540 O  O   . LEU A 1 394 ? 101.812 112.841 138.415 1.00 68.11  ? 394 LEU A O   1 
ATOM   2541 C  CB  . LEU A 1 394 ? 102.345 112.874 135.323 1.00 58.54  ? 394 LEU A CB  1 
ATOM   2542 C  CG  . LEU A 1 394 ? 103.401 112.377 134.336 1.00 60.19  ? 394 LEU A CG  1 
ATOM   2543 C  CD1 . LEU A 1 394 ? 103.700 113.439 133.295 1.00 59.32  ? 394 LEU A CD1 1 
ATOM   2544 C  CD2 . LEU A 1 394 ? 104.664 111.969 135.071 1.00 60.52  ? 394 LEU A CD2 1 
ATOM   2545 N  N   . THR A 1 395 ? 99.792  112.731 137.422 1.00 63.62  ? 395 THR A N   1 
ATOM   2546 C  CA  . THR A 1 395 ? 99.105  113.343 138.554 1.00 62.38  ? 395 THR A CA  1 
ATOM   2547 C  C   . THR A 1 395 ? 99.168  112.480 139.811 1.00 68.79  ? 395 THR A C   1 
ATOM   2548 O  O   . THR A 1 395 ? 99.387  113.015 140.903 1.00 71.79  ? 395 THR A O   1 
ATOM   2549 C  CB  . THR A 1 395 ? 97.647  113.631 138.181 1.00 63.23  ? 395 THR A CB  1 
ATOM   2550 O  OG1 . THR A 1 395 ? 97.577  114.847 137.429 1.00 65.16  ? 395 THR A OG1 1 
ATOM   2551 C  CG2 . THR A 1 395 ? 96.777  113.764 139.422 1.00 64.78  ? 395 THR A CG2 1 
ATOM   2552 N  N   . LEU A 1 396 ? 99.010  111.165 139.680 1.00 72.83  ? 396 LEU A N   1 
ATOM   2553 C  CA  . LEU A 1 396 ? 98.897  110.265 140.821 1.00 70.62  ? 396 LEU A CA  1 
ATOM   2554 C  C   . LEU A 1 396 ? 100.215 110.027 141.548 1.00 70.60  ? 396 LEU A C   1 
ATOM   2555 O  O   . LEU A 1 396 ? 100.198 109.511 142.670 1.00 72.96  ? 396 LEU A O   1 
ATOM   2556 C  CB  . LEU A 1 396 ? 98.322  108.919 140.366 1.00 69.95  ? 396 LEU A CB  1 
ATOM   2557 C  CG  . LEU A 1 396 ? 96.873  108.926 139.881 1.00 69.92  ? 396 LEU A CG  1 
ATOM   2558 C  CD1 . LEU A 1 396 ? 96.677  107.901 138.778 1.00 70.15  ? 396 LEU A CD1 1 
ATOM   2559 C  CD2 . LEU A 1 396 ? 95.920  108.665 141.033 1.00 67.95  ? 396 LEU A CD2 1 
ATOM   2560 N  N   . LEU A 1 397 ? 101.353 110.386 140.948 1.00 68.42  ? 397 LEU A N   1 
ATOM   2561 C  CA  . LEU A 1 397 ? 102.615 110.125 141.624 1.00 65.13  ? 397 LEU A CA  1 
ATOM   2562 C  C   . LEU A 1 397 ? 102.874 111.161 142.713 1.00 67.91  ? 397 LEU A C   1 
ATOM   2563 O  O   . LEU A 1 397 ? 102.461 112.318 142.589 1.00 71.60  ? 397 LEU A O   1 
ATOM   2564 C  CB  . LEU A 1 397 ? 103.768 110.143 140.624 1.00 63.77  ? 397 LEU A CB  1 
ATOM   2565 C  CG  . LEU A 1 397 ? 103.956 108.901 139.757 1.00 66.53  ? 397 LEU A CG  1 
ATOM   2566 C  CD1 . LEU A 1 397 ? 104.811 109.224 138.545 1.00 62.76  ? 397 LEU A CD1 1 
ATOM   2567 C  CD2 . LEU A 1 397 ? 104.579 107.779 140.567 1.00 66.79  ? 397 LEU A CD2 1 
ATOM   2568 N  N   . PRO A 1 398 ? 103.548 110.772 143.796 1.00 72.95  ? 398 PRO A N   1 
ATOM   2569 C  CA  . PRO A 1 398 ? 103.954 111.763 144.803 1.00 72.38  ? 398 PRO A CA  1 
ATOM   2570 C  C   . PRO A 1 398 ? 104.973 112.730 144.218 1.00 72.01  ? 398 PRO A C   1 
ATOM   2571 O  O   . PRO A 1 398 ? 105.863 112.330 143.463 1.00 73.58  ? 398 PRO A O   1 
ATOM   2572 C  CB  . PRO A 1 398 ? 104.557 110.910 145.925 1.00 70.07  ? 398 PRO A CB  1 
ATOM   2573 C  CG  . PRO A 1 398 ? 104.943 109.628 145.270 1.00 73.76  ? 398 PRO A CG  1 
ATOM   2574 C  CD  . PRO A 1 398 ? 103.961 109.406 144.159 1.00 73.99  ? 398 PRO A CD  1 
ATOM   2575 N  N   . ILE A 1 399 ? 104.835 114.008 144.578 1.00 70.64  ? 399 ILE A N   1 
ATOM   2576 C  CA  . ILE A 1 399 ? 105.647 115.086 144.020 1.00 69.57  ? 399 ILE A CA  1 
ATOM   2577 C  C   . ILE A 1 399 ? 105.515 115.056 142.502 1.00 69.31  ? 399 ILE A C   1 
ATOM   2578 O  O   . ILE A 1 399 ? 106.456 114.692 141.790 1.00 77.32  ? 399 ILE A O   1 
ATOM   2579 C  CB  . ILE A 1 399 ? 107.119 114.980 144.462 1.00 69.15  ? 399 ILE A CB  1 
ATOM   2580 C  CG1 . ILE A 1 399 ? 107.207 114.649 145.954 1.00 68.35  ? 399 ILE A CG1 1 
ATOM   2581 C  CG2 . ILE A 1 399 ? 107.866 116.271 144.157 1.00 69.48  ? 399 ILE A CG2 1 
ATOM   2582 C  CD1 . ILE A 1 399 ? 107.143 115.858 146.862 1.00 68.63  ? 399 ILE A CD1 1 
ATOM   2583 N  N   . SER A 1 400 ? 104.341 115.432 142.004 1.00 61.59  ? 400 SER A N   1 
ATOM   2584 C  CA  . SER A 1 400 ? 103.990 115.353 140.590 1.00 59.49  ? 400 SER A CA  1 
ATOM   2585 C  C   . SER A 1 400 ? 104.825 116.261 139.684 1.00 66.41  ? 400 SER A C   1 
ATOM   2586 O  O   . SER A 1 400 ? 105.249 115.810 138.611 1.00 69.60  ? 400 SER A O   1 
ATOM   2587 C  CB  . SER A 1 400 ? 102.503 115.664 140.406 1.00 65.85  ? 400 SER A CB  1 
ATOM   2588 O  OG  . SER A 1 400 ? 101.729 115.072 141.435 1.00 67.29  ? 400 SER A OG  1 
ATOM   2589 N  N   . PRO A 1 401 ? 105.053 117.539 140.035 1.00 70.82  ? 401 PRO A N   1 
ATOM   2590 C  CA  . PRO A 1 401 ? 105.776 118.417 139.096 1.00 66.85  ? 401 PRO A CA  1 
ATOM   2591 C  C   . PRO A 1 401 ? 107.165 117.925 138.724 1.00 71.15  ? 401 PRO A C   1 
ATOM   2592 O  O   . PRO A 1 401 ? 107.579 118.092 137.572 1.00 69.98  ? 401 PRO A O   1 
ATOM   2593 C  CB  . PRO A 1 401 ? 105.830 119.753 139.849 1.00 61.99  ? 401 PRO A CB  1 
ATOM   2594 C  CG  . PRO A 1 401 ? 104.650 119.721 140.736 1.00 57.73  ? 401 PRO A CG  1 
ATOM   2595 C  CD  . PRO A 1 401 ? 104.567 118.302 141.201 1.00 64.31  ? 401 PRO A CD  1 
ATOM   2596 N  N   . LEU A 1 402 ? 107.897 117.319 139.662 1.00 64.06  ? 402 LEU A N   1 
ATOM   2597 C  CA  . LEU A 1 402 ? 109.238 116.830 139.354 1.00 63.67  ? 402 LEU A CA  1 
ATOM   2598 C  C   . LEU A 1 402 ? 109.192 115.719 138.310 1.00 65.43  ? 402 LEU A C   1 
ATOM   2599 O  O   . LEU A 1 402 ? 109.965 115.719 137.341 1.00 68.47  ? 402 LEU A O   1 
ATOM   2600 C  CB  . LEU A 1 402 ? 109.916 116.343 140.634 1.00 63.15  ? 402 LEU A CB  1 
ATOM   2601 C  CG  . LEU A 1 402 ? 111.400 115.985 140.545 1.00 71.49  ? 402 LEU A CG  1 
ATOM   2602 C  CD1 . LEU A 1 402 ? 112.253 117.134 141.055 1.00 71.11  ? 402 LEU A CD1 1 
ATOM   2603 C  CD2 . LEU A 1 402 ? 111.692 114.713 141.322 1.00 65.39  ? 402 LEU A CD2 1 
ATOM   2604 N  N   . TRP A 1 403 ? 108.277 114.765 138.489 1.00 57.48  ? 403 TRP A N   1 
ATOM   2605 C  CA  . TRP A 1 403 ? 108.157 113.669 137.537 1.00 57.40  ? 403 TRP A CA  1 
ATOM   2606 C  C   . TRP A 1 403 ? 107.655 114.164 136.187 1.00 61.23  ? 403 TRP A C   1 
ATOM   2607 O  O   . TRP A 1 403 ? 108.087 113.667 135.141 1.00 65.60  ? 403 TRP A O   1 
ATOM   2608 C  CB  . TRP A 1 403 ? 107.241 112.587 138.103 1.00 62.12  ? 403 TRP A CB  1 
ATOM   2609 C  CG  . TRP A 1 403 ? 107.795 111.956 139.342 1.00 67.85  ? 403 TRP A CG  1 
ATOM   2610 C  CD1 . TRP A 1 403 ? 107.311 112.077 140.610 1.00 63.29  ? 403 TRP A CD1 1 
ATOM   2611 C  CD2 . TRP A 1 403 ? 108.955 111.120 139.434 1.00 63.48  ? 403 TRP A CD2 1 
ATOM   2612 N  NE1 . TRP A 1 403 ? 108.090 111.362 141.485 1.00 63.72  ? 403 TRP A NE1 1 
ATOM   2613 C  CE2 . TRP A 1 403 ? 109.107 110.765 140.788 1.00 61.09  ? 403 TRP A CE2 1 
ATOM   2614 C  CE3 . TRP A 1 403 ? 109.876 110.635 138.502 1.00 62.76  ? 403 TRP A CE3 1 
ATOM   2615 C  CZ2 . TRP A 1 403 ? 110.141 109.947 141.233 1.00 59.35  ? 403 TRP A CZ2 1 
ATOM   2616 C  CZ3 . TRP A 1 403 ? 110.902 109.823 138.946 1.00 66.57  ? 403 TRP A CZ3 1 
ATOM   2617 C  CH2 . TRP A 1 403 ? 111.027 109.487 140.299 1.00 67.00  ? 403 TRP A CH2 1 
ATOM   2618 N  N   . SER A 1 404 ? 106.747 115.144 136.188 1.00 52.96  ? 404 SER A N   1 
ATOM   2619 C  CA  . SER A 1 404 ? 106.300 115.728 134.927 1.00 53.43  ? 404 SER A CA  1 
ATOM   2620 C  C   . SER A 1 404 ? 107.451 116.408 134.198 1.00 58.03  ? 404 SER A C   1 
ATOM   2621 O  O   . SER A 1 404 ? 107.600 116.261 132.976 1.00 61.99  ? 404 SER A O   1 
ATOM   2622 C  CB  . SER A 1 404 ? 105.167 116.720 135.182 1.00 57.39  ? 404 SER A CB  1 
ATOM   2623 O  OG  . SER A 1 404 ? 104.019 116.064 135.690 1.00 61.97  ? 404 SER A OG  1 
ATOM   2624 N  N   . LEU A 1 405 ? 108.280 117.153 134.933 1.00 55.66  ? 405 LEU A N   1 
ATOM   2625 C  CA  . LEU A 1 405 ? 109.433 117.809 134.328 1.00 54.91  ? 405 LEU A CA  1 
ATOM   2626 C  C   . LEU A 1 405 ? 110.375 116.787 133.711 1.00 61.71  ? 405 LEU A C   1 
ATOM   2627 O  O   . LEU A 1 405 ? 110.822 116.949 132.570 1.00 73.50  ? 405 LEU A O   1 
ATOM   2628 C  CB  . LEU A 1 405 ? 110.167 118.648 135.375 1.00 57.42  ? 405 LEU A CB  1 
ATOM   2629 C  CG  . LEU A 1 405 ? 109.598 120.021 135.734 1.00 61.12  ? 405 LEU A CG  1 
ATOM   2630 C  CD1 . LEU A 1 405 ? 110.216 120.522 137.027 1.00 61.08  ? 405 LEU A CD1 1 
ATOM   2631 C  CD2 . LEU A 1 405 ? 109.826 121.017 134.617 1.00 60.78  ? 405 LEU A CD2 1 
ATOM   2632 N  N   . LEU A 1 406 ? 110.679 115.717 134.450 1.00 56.03  ? 406 LEU A N   1 
ATOM   2633 C  CA  . LEU A 1 406 ? 111.577 114.692 133.922 1.00 50.14  ? 406 LEU A CA  1 
ATOM   2634 C  C   . LEU A 1 406 ? 110.987 114.010 132.692 1.00 49.70  ? 406 LEU A C   1 
ATOM   2635 O  O   . LEU A 1 406 ? 111.693 113.781 131.702 1.00 56.84  ? 406 LEU A O   1 
ATOM   2636 C  CB  . LEU A 1 406 ? 111.901 113.664 135.005 1.00 50.32  ? 406 LEU A CB  1 
ATOM   2637 C  CG  . LEU A 1 406 ? 112.712 114.181 136.195 1.00 55.62  ? 406 LEU A CG  1 
ATOM   2638 C  CD1 . LEU A 1 406 ? 112.750 113.154 137.313 1.00 56.53  ? 406 LEU A CD1 1 
ATOM   2639 C  CD2 . LEU A 1 406 ? 114.118 114.554 135.760 1.00 51.51  ? 406 LEU A CD2 1 
ATOM   2640 N  N   . PHE A 1 407 ? 109.692 113.687 132.731 1.00 41.06  ? 407 PHE A N   1 
ATOM   2641 C  CA  . PHE A 1 407 ? 109.059 112.999 131.610 1.00 49.87  ? 407 PHE A CA  1 
ATOM   2642 C  C   . PHE A 1 407 ? 109.073 113.857 130.350 1.00 54.36  ? 407 PHE A C   1 
ATOM   2643 O  O   . PHE A 1 407 ? 109.417 113.377 129.259 1.00 58.62  ? 407 PHE A O   1 
ATOM   2644 C  CB  . PHE A 1 407 ? 107.629 112.613 131.993 1.00 46.71  ? 407 PHE A CB  1 
ATOM   2645 C  CG  . PHE A 1 407 ? 106.856 111.962 130.887 1.00 52.49  ? 407 PHE A CG  1 
ATOM   2646 C  CD1 . PHE A 1 407 ? 107.019 110.617 130.610 1.00 53.96  ? 407 PHE A CD1 1 
ATOM   2647 C  CD2 . PHE A 1 407 ? 105.957 112.691 130.130 1.00 44.90  ? 407 PHE A CD2 1 
ATOM   2648 C  CE1 . PHE A 1 407 ? 106.307 110.015 129.595 1.00 54.04  ? 407 PHE A CE1 1 
ATOM   2649 C  CE2 . PHE A 1 407 ? 105.244 112.094 129.114 1.00 46.00  ? 407 PHE A CE2 1 
ATOM   2650 C  CZ  . PHE A 1 407 ? 105.420 110.755 128.847 1.00 48.89  ? 407 PHE A CZ  1 
ATOM   2651 N  N   . PHE A 1 408 ? 108.724 115.138 130.477 1.00 50.69  ? 408 PHE A N   1 
ATOM   2652 C  CA  . PHE A 1 408 ? 108.693 115.988 129.295 1.00 48.13  ? 408 PHE A CA  1 
ATOM   2653 C  C   . PHE A 1 408 ? 110.093 116.350 128.814 1.00 48.90  ? 408 PHE A C   1 
ATOM   2654 O  O   . PHE A 1 408 ? 110.300 116.525 127.608 1.00 52.76  ? 408 PHE A O   1 
ATOM   2655 C  CB  . PHE A 1 408 ? 107.853 117.233 129.574 1.00 48.51  ? 408 PHE A CB  1 
ATOM   2656 C  CG  . PHE A 1 408 ? 106.376 116.958 129.610 1.00 47.77  ? 408 PHE A CG  1 
ATOM   2657 C  CD1 . PHE A 1 408 ? 105.717 116.506 128.480 1.00 47.47  ? 408 PHE A CD1 1 
ATOM   2658 C  CD2 . PHE A 1 408 ? 105.651 117.127 130.775 1.00 52.54  ? 408 PHE A CD2 1 
ATOM   2659 C  CE1 . PHE A 1 408 ? 104.363 116.242 128.508 1.00 36.62  ? 408 PHE A CE1 1 
ATOM   2660 C  CE2 . PHE A 1 408 ? 104.296 116.863 130.809 1.00 50.72  ? 408 PHE A CE2 1 
ATOM   2661 C  CZ  . PHE A 1 408 ? 103.652 116.422 129.674 1.00 39.14  ? 408 PHE A CZ  1 
ATOM   2662 N  N   . PHE A 1 409 ? 111.071 116.424 129.722 1.00 41.19  ? 409 PHE A N   1 
ATOM   2663 C  CA  . PHE A 1 409 ? 112.460 116.566 129.301 1.00 44.35  ? 409 PHE A CA  1 
ATOM   2664 C  C   . PHE A 1 409 ? 112.910 115.360 128.485 1.00 51.71  ? 409 PHE A C   1 
ATOM   2665 O  O   . PHE A 1 409 ? 113.606 115.506 127.471 1.00 55.89  ? 409 PHE A O   1 
ATOM   2666 C  CB  . PHE A 1 409 ? 113.351 116.752 130.529 1.00 43.57  ? 409 PHE A CB  1 
ATOM   2667 C  CG  . PHE A 1 409 ? 114.786 117.033 130.203 1.00 52.32  ? 409 PHE A CG  1 
ATOM   2668 C  CD1 . PHE A 1 409 ? 115.147 118.194 129.543 1.00 56.60  ? 409 PHE A CD1 1 
ATOM   2669 C  CD2 . PHE A 1 409 ? 115.777 116.136 130.560 1.00 50.31  ? 409 PHE A CD2 1 
ATOM   2670 C  CE1 . PHE A 1 409 ? 116.468 118.454 129.244 1.00 57.06  ? 409 PHE A CE1 1 
ATOM   2671 C  CE2 . PHE A 1 409 ? 117.100 116.390 130.262 1.00 54.40  ? 409 PHE A CE2 1 
ATOM   2672 C  CZ  . PHE A 1 409 ? 117.446 117.551 129.604 1.00 53.96  ? 409 PHE A CZ  1 
ATOM   2673 N  N   . MET A 1 410 ? 112.518 114.158 128.914 1.00 52.54  ? 410 MET A N   1 
ATOM   2674 C  CA  . MET A 1 410 ? 112.843 112.954 128.157 1.00 50.05  ? 410 MET A CA  1 
ATOM   2675 C  C   . MET A 1 410 ? 112.199 112.978 126.776 1.00 55.26  ? 410 MET A C   1 
ATOM   2676 O  O   . MET A 1 410 ? 112.829 112.599 125.780 1.00 60.75  ? 410 MET A O   1 
ATOM   2677 C  CB  . MET A 1 410 ? 112.404 111.718 128.943 1.00 51.02  ? 410 MET A CB  1 
ATOM   2678 C  CG  . MET A 1 410 ? 112.427 110.420 128.159 1.00 59.65  ? 410 MET A CG  1 
ATOM   2679 S  SD  . MET A 1 410 ? 111.151 109.272 128.711 1.00 82.03  ? 410 MET A SD  1 
ATOM   2680 C  CE  . MET A 1 410 ? 110.026 109.306 127.323 1.00 54.75  ? 410 MET A CE  1 
ATOM   2681 N  N   . LEU A 1 411 ? 110.942 113.423 126.696 1.00 47.34  ? 411 LEU A N   1 
ATOM   2682 C  CA  . LEU A 1 411 ? 110.286 113.545 125.394 1.00 41.34  ? 411 LEU A CA  1 
ATOM   2683 C  C   . LEU A 1 411 ? 111.018 114.533 124.489 1.00 45.29  ? 411 LEU A C   1 
ATOM   2684 O  O   . LEU A 1 411 ? 111.207 114.274 123.291 1.00 50.44  ? 411 LEU A O   1 
ATOM   2685 C  CB  . LEU A 1 411 ? 108.829 113.970 125.577 1.00 46.41  ? 411 LEU A CB  1 
ATOM   2686 C  CG  . LEU A 1 411 ? 107.902 112.985 126.290 1.00 51.24  ? 411 LEU A CG  1 
ATOM   2687 C  CD1 . LEU A 1 411 ? 106.541 113.606 126.524 1.00 51.50  ? 411 LEU A CD1 1 
ATOM   2688 C  CD2 . LEU A 1 411 ? 107.776 111.698 125.494 1.00 48.24  ? 411 LEU A CD2 1 
ATOM   2689 N  N   . ILE A 1 412 ? 111.433 115.674 125.046 1.00 50.50  ? 412 ILE A N   1 
ATOM   2690 C  CA  . ILE A 1 412 ? 112.151 116.675 124.261 1.00 40.72  ? 412 ILE A CA  1 
ATOM   2691 C  C   . ILE A 1 412 ? 113.463 116.105 123.738 1.00 48.77  ? 412 ILE A C   1 
ATOM   2692 O  O   . ILE A 1 412 ? 113.831 116.319 122.576 1.00 56.21  ? 412 ILE A O   1 
ATOM   2693 C  CB  . ILE A 1 412 ? 112.378 117.947 125.101 1.00 46.99  ? 412 ILE A CB  1 
ATOM   2694 C  CG1 . ILE A 1 412 ? 111.060 118.690 125.317 1.00 49.52  ? 412 ILE A CG1 1 
ATOM   2695 C  CG2 . ILE A 1 412 ? 113.394 118.860 124.436 1.00 47.88  ? 412 ILE A CG2 1 
ATOM   2696 C  CD1 . ILE A 1 412 ? 111.063 119.590 126.531 1.00 44.83  ? 412 ILE A CD1 1 
ATOM   2697 N  N   . LEU A 1 413 ? 114.193 115.377 124.588 1.00 44.50  ? 413 LEU A N   1 
ATOM   2698 C  CA  . LEU A 1 413 ? 115.447 114.766 124.153 1.00 46.13  ? 413 LEU A CA  1 
ATOM   2699 C  C   . LEU A 1 413 ? 115.211 113.745 123.045 1.00 48.88  ? 413 LEU A C   1 
ATOM   2700 O  O   . LEU A 1 413 ? 115.964 113.697 122.060 1.00 56.74  ? 413 LEU A O   1 
ATOM   2701 C  CB  . LEU A 1 413 ? 116.150 114.110 125.340 1.00 48.57  ? 413 LEU A CB  1 
ATOM   2702 C  CG  . LEU A 1 413 ? 116.861 115.027 126.337 1.00 54.22  ? 413 LEU A CG  1 
ATOM   2703 C  CD1 . LEU A 1 413 ? 117.957 114.268 127.060 1.00 56.74  ? 413 LEU A CD1 1 
ATOM   2704 C  CD2 . LEU A 1 413 ? 117.426 116.258 125.646 1.00 55.40  ? 413 LEU A CD2 1 
ATOM   2705 N  N   . LEU A 1 414 ? 114.169 112.921 123.190 1.00 46.02  ? 414 LEU A N   1 
ATOM   2706 C  CA  . LEU A 1 414 ? 113.856 111.927 122.167 1.00 44.12  ? 414 LEU A CA  1 
ATOM   2707 C  C   . LEU A 1 414 ? 113.558 112.588 120.829 1.00 48.68  ? 414 LEU A C   1 
ATOM   2708 O  O   . LEU A 1 414 ? 113.998 112.106 119.779 1.00 52.23  ? 414 LEU A O   1 
ATOM   2709 C  CB  . LEU A 1 414 ? 112.668 111.071 122.608 1.00 43.15  ? 414 LEU A CB  1 
ATOM   2710 C  CG  . LEU A 1 414 ? 112.938 109.846 123.482 1.00 51.60  ? 414 LEU A CG  1 
ATOM   2711 C  CD1 . LEU A 1 414 ? 111.732 108.924 123.483 1.00 44.95  ? 414 LEU A CD1 1 
ATOM   2712 C  CD2 . LEU A 1 414 ? 114.177 109.103 123.019 1.00 52.47  ? 414 LEU A CD2 1 
ATOM   2713 N  N   . GLY A 1 415 ? 112.801 113.686 120.843 1.00 45.07  ? 415 GLY A N   1 
ATOM   2714 C  CA  . GLY A 1 415 ? 112.531 114.394 119.600 1.00 45.47  ? 415 GLY A CA  1 
ATOM   2715 C  C   . GLY A 1 415 ? 113.770 115.032 118.993 1.00 47.15  ? 415 GLY A C   1 
ATOM   2716 O  O   . GLY A 1 415 ? 113.997 114.944 117.779 1.00 49.07  ? 415 GLY A O   1 
ATOM   2717 N  N   . LEU A 1 416 ? 114.584 115.687 119.826 1.00 39.29  ? 416 LEU A N   1 
ATOM   2718 C  CA  . LEU A 1 416 ? 115.743 116.417 119.317 1.00 41.87  ? 416 LEU A CA  1 
ATOM   2719 C  C   . LEU A 1 416 ? 116.771 115.474 118.707 1.00 39.63  ? 416 LEU A C   1 
ATOM   2720 O  O   . LEU A 1 416 ? 117.416 115.813 117.705 1.00 55.41  ? 416 LEU A O   1 
ATOM   2721 C  CB  . LEU A 1 416 ? 116.375 117.244 120.435 1.00 44.28  ? 416 LEU A CB  1 
ATOM   2722 C  CG  . LEU A 1 416 ? 115.660 118.538 120.828 1.00 49.97  ? 416 LEU A CG  1 
ATOM   2723 C  CD1 . LEU A 1 416 ? 116.550 119.385 121.719 1.00 50.87  ? 416 LEU A CD1 1 
ATOM   2724 C  CD2 . LEU A 1 416 ? 115.229 119.319 119.601 1.00 49.54  ? 416 LEU A CD2 1 
ATOM   2725 N  N   . GLY A 1 417 ? 116.949 114.293 119.305 1.00 45.98  ? 417 GLY A N   1 
ATOM   2726 C  CA  . GLY A 1 417 ? 117.906 113.343 118.760 1.00 48.10  ? 417 GLY A CA  1 
ATOM   2727 C  C   . GLY A 1 417 ? 117.611 112.968 117.320 1.00 49.90  ? 417 GLY A C   1 
ATOM   2728 O  O   . GLY A 1 417 ? 118.524 112.845 116.500 1.00 49.93  ? 417 GLY A O   1 
ATOM   2729 N  N   . THR A 1 418 ? 116.332 112.777 116.993 1.00 51.76  ? 418 THR A N   1 
ATOM   2730 C  CA  . THR A 1 418 ? 115.949 112.453 115.623 1.00 46.16  ? 418 THR A CA  1 
ATOM   2731 C  C   . THR A 1 418 ? 115.987 113.682 114.720 1.00 48.94  ? 418 THR A C   1 
ATOM   2732 O  O   . THR A 1 418 ? 116.407 113.587 113.558 1.00 54.10  ? 418 THR A O   1 
ATOM   2733 C  CB  . THR A 1 418 ? 114.557 111.818 115.610 1.00 48.64  ? 418 THR A CB  1 
ATOM   2734 O  OG1 . THR A 1 418 ? 114.594 110.574 116.319 1.00 46.21  ? 418 THR A OG1 1 
ATOM   2735 C  CG2 . THR A 1 418 ? 114.090 111.562 114.188 1.00 50.36  ? 418 THR A CG2 1 
ATOM   2736 N  N   . GLN A 1 419 ? 115.561 114.842 115.234 1.00 46.34  ? 419 GLN A N   1 
ATOM   2737 C  CA  . GLN A 1 419 ? 115.532 116.046 114.406 1.00 42.62  ? 419 GLN A CA  1 
ATOM   2738 C  C   . GLN A 1 419 ? 116.928 116.464 113.955 1.00 46.54  ? 419 GLN A C   1 
ATOM   2739 O  O   . GLN A 1 419 ? 117.101 116.924 112.815 1.00 52.62  ? 419 GLN A O   1 
ATOM   2740 C  CB  . GLN A 1 419 ? 114.852 117.185 115.164 1.00 42.78  ? 419 GLN A CB  1 
ATOM   2741 C  CG  . GLN A 1 419 ? 114.565 118.414 114.319 1.00 50.74  ? 419 GLN A CG  1 
ATOM   2742 C  CD  . GLN A 1 419 ? 113.309 118.270 113.485 1.00 51.69  ? 419 GLN A CD  1 
ATOM   2743 O  OE1 . GLN A 1 419 ? 112.406 117.512 113.830 1.00 59.34  ? 419 GLN A OE1 1 
ATOM   2744 N  NE2 . GLN A 1 419 ? 113.244 119.004 112.383 1.00 46.93  ? 419 GLN A NE2 1 
ATOM   2745 N  N   . PHE A 1 420 ? 117.928 116.326 114.832 1.00 49.57  ? 420 PHE A N   1 
ATOM   2746 C  CA  . PHE A 1 420 ? 119.298 116.671 114.461 1.00 47.07  ? 420 PHE A CA  1 
ATOM   2747 C  C   . PHE A 1 420 ? 119.735 115.909 113.216 1.00 50.75  ? 420 PHE A C   1 
ATOM   2748 O  O   . PHE A 1 420 ? 120.202 116.503 112.235 1.00 63.15  ? 420 PHE A O   1 
ATOM   2749 C  CB  . PHE A 1 420 ? 120.248 116.369 115.620 1.00 45.88  ? 420 PHE A CB  1 
ATOM   2750 C  CG  . PHE A 1 420 ? 120.112 117.305 116.786 1.00 57.71  ? 420 PHE A CG  1 
ATOM   2751 C  CD1 . PHE A 1 420 ? 119.393 118.482 116.674 1.00 62.85  ? 420 PHE A CD1 1 
ATOM   2752 C  CD2 . PHE A 1 420 ? 120.694 116.996 118.004 1.00 60.58  ? 420 PHE A CD2 1 
ATOM   2753 C  CE1 . PHE A 1 420 ? 119.266 119.336 117.752 1.00 61.34  ? 420 PHE A CE1 1 
ATOM   2754 C  CE2 . PHE A 1 420 ? 120.569 117.846 119.084 1.00 57.76  ? 420 PHE A CE2 1 
ATOM   2755 C  CZ  . PHE A 1 420 ? 119.853 119.015 118.958 1.00 54.18  ? 420 PHE A CZ  1 
ATOM   2756 N  N   . CYS A 1 421 ? 119.576 114.584 113.238 1.00 53.13  ? 421 CYS A N   1 
ATOM   2757 C  CA  . CYS A 1 421 ? 119.978 113.759 112.105 1.00 55.35  ? 421 CYS A CA  1 
ATOM   2758 C  C   . CYS A 1 421 ? 119.121 114.045 110.880 1.00 57.94  ? 421 CYS A C   1 
ATOM   2759 O  O   . CYS A 1 421 ? 119.625 114.036 109.750 1.00 60.04  ? 421 CYS A O   1 
ATOM   2760 C  CB  . CYS A 1 421 ? 119.896 112.282 112.485 1.00 61.37  ? 421 CYS A CB  1 
ATOM   2761 S  SG  . CYS A 1 421 ? 121.005 111.798 113.829 1.00 90.00  ? 421 CYS A SG  1 
ATOM   2762 N  N   . LEU A 1 422 ? 117.826 114.306 111.082 1.00 54.69  ? 422 LEU A N   1 
ATOM   2763 C  CA  . LEU A 1 422 ? 116.949 114.592 109.952 1.00 48.60  ? 422 LEU A CA  1 
ATOM   2764 C  C   . LEU A 1 422 ? 117.410 115.830 109.193 1.00 48.99  ? 422 LEU A C   1 
ATOM   2765 O  O   . LEU A 1 422 ? 117.407 115.844 107.957 1.00 47.52  ? 422 LEU A O   1 
ATOM   2766 C  CB  . LEU A 1 422 ? 115.510 114.767 110.433 1.00 51.94  ? 422 LEU A CB  1 
ATOM   2767 C  CG  . LEU A 1 422 ? 114.410 114.635 109.379 1.00 47.07  ? 422 LEU A CG  1 
ATOM   2768 C  CD1 . LEU A 1 422 ? 113.215 113.902 109.950 1.00 53.54  ? 422 LEU A CD1 1 
ATOM   2769 C  CD2 . LEU A 1 422 ? 113.997 116.000 108.858 1.00 50.97  ? 422 LEU A CD2 1 
ATOM   2770 N  N   . LEU A 1 423 ? 117.804 116.883 109.912 1.00 55.79  ? 423 LEU A N   1 
ATOM   2771 C  CA  . LEU A 1 423 ? 118.263 118.086 109.221 1.00 51.25  ? 423 LEU A CA  1 
ATOM   2772 C  C   . LEU A 1 423 ? 119.676 117.918 108.666 1.00 52.61  ? 423 LEU A C   1 
ATOM   2773 O  O   . LEU A 1 423 ? 119.989 118.430 107.579 1.00 61.22  ? 423 LEU A O   1 
ATOM   2774 C  CB  . LEU A 1 423 ? 118.194 119.292 110.156 1.00 50.17  ? 423 LEU A CB  1 
ATOM   2775 C  CG  . LEU A 1 423 ? 117.841 120.603 109.448 1.00 59.89  ? 423 LEU A CG  1 
ATOM   2776 C  CD1 . LEU A 1 423 ? 116.338 120.702 109.255 1.00 62.39  ? 423 LEU A CD1 1 
ATOM   2777 C  CD2 . LEU A 1 423 ? 118.367 121.810 110.205 1.00 58.86  ? 423 LEU A CD2 1 
ATOM   2778 N  N   . GLU A 1 424 ? 120.536 117.199 109.395 1.00 54.84  ? 424 GLU A N   1 
ATOM   2779 C  CA  . GLU A 1 424 ? 121.904 116.990 108.935 1.00 48.84  ? 424 GLU A CA  1 
ATOM   2780 C  C   . GLU A 1 424 ? 121.935 116.211 107.627 1.00 55.06  ? 424 GLU A C   1 
ATOM   2781 O  O   . GLU A 1 424 ? 122.752 116.500 106.744 1.00 60.88  ? 424 GLU A O   1 
ATOM   2782 C  CB  . GLU A 1 424 ? 122.708 116.267 110.016 1.00 53.96  ? 424 GLU A CB  1 
ATOM   2783 C  CG  . GLU A 1 424 ? 124.066 115.767 109.564 1.00 57.40  ? 424 GLU A CG  1 
ATOM   2784 C  CD  . GLU A 1 424 ? 125.188 116.710 109.941 1.00 69.47  ? 424 GLU A CD  1 
ATOM   2785 O  OE1 . GLU A 1 424 ? 125.064 117.923 109.671 1.00 73.53  ? 424 GLU A OE1 1 
ATOM   2786 O  OE2 . GLU A 1 424 ? 126.196 116.240 110.509 1.00 72.77  ? 424 GLU A OE2 1 
ATOM   2787 N  N   . THR A 1 425 ? 121.055 115.216 107.484 1.00 55.30  ? 425 THR A N   1 
ATOM   2788 C  CA  . THR A 1 425 ? 121.012 114.437 106.250 1.00 53.27  ? 425 THR A CA  1 
ATOM   2789 C  C   . THR A 1 425 ? 120.672 115.313 105.050 1.00 54.53  ? 425 THR A C   1 
ATOM   2790 O  O   . THR A 1 425 ? 121.321 115.218 104.001 1.00 53.19  ? 425 THR A O   1 
ATOM   2791 C  CB  . THR A 1 425 ? 120.002 113.297 106.388 1.00 56.53  ? 425 THR A CB  1 
ATOM   2792 O  OG1 . THR A 1 425 ? 120.543 112.280 107.239 1.00 62.68  ? 425 THR A OG1 1 
ATOM   2793 C  CG2 . THR A 1 425 ? 119.678 112.693 105.031 1.00 58.52  ? 425 THR A CG2 1 
ATOM   2794 N  N   . LEU A 1 426 ? 119.663 116.178 105.186 1.00 52.09  ? 426 LEU A N   1 
ATOM   2795 C  CA  . LEU A 1 426 ? 119.284 117.057 104.084 1.00 47.49  ? 426 LEU A CA  1 
ATOM   2796 C  C   . LEU A 1 426 ? 120.410 118.021 103.736 1.00 50.81  ? 426 LEU A C   1 
ATOM   2797 O  O   . LEU A 1 426 ? 120.704 118.250 102.554 1.00 68.42  ? 426 LEU A O   1 
ATOM   2798 C  CB  . LEU A 1 426 ? 118.012 117.830 104.436 1.00 49.79  ? 426 LEU A CB  1 
ATOM   2799 C  CG  . LEU A 1 426 ? 116.692 117.058 104.455 1.00 62.18  ? 426 LEU A CG  1 
ATOM   2800 C  CD1 . LEU A 1 426 ? 115.549 117.979 104.844 1.00 59.90  ? 426 LEU A CD1 1 
ATOM   2801 C  CD2 . LEU A 1 426 ? 116.426 116.414 103.107 1.00 56.67  ? 426 LEU A CD2 1 
ATOM   2802 N  N   . VAL A 1 427 ? 121.051 118.603 104.753 1.00 54.59  ? 427 VAL A N   1 
ATOM   2803 C  CA  . VAL A 1 427 ? 122.133 119.548 104.481 1.00 53.93  ? 427 VAL A CA  1 
ATOM   2804 C  C   . VAL A 1 427 ? 123.284 118.852 103.763 1.00 50.89  ? 427 VAL A C   1 
ATOM   2805 O  O   . VAL A 1 427 ? 123.830 119.373 102.780 1.00 51.25  ? 427 VAL A O   1 
ATOM   2806 C  CB  . VAL A 1 427 ? 122.598 120.224 105.783 1.00 60.79  ? 427 VAL A CB  1 
ATOM   2807 C  CG1 . VAL A 1 427 ? 123.891 120.988 105.553 1.00 55.81  ? 427 VAL A CG1 1 
ATOM   2808 C  CG2 . VAL A 1 427 ? 121.517 121.151 106.309 1.00 54.01  ? 427 VAL A CG2 1 
ATOM   2809 N  N   . THR A 1 428 ? 123.663 117.661 104.234 1.00 59.73  ? 428 THR A N   1 
ATOM   2810 C  CA  . THR A 1 428 ? 124.748 116.919 103.599 1.00 62.05  ? 428 THR A CA  1 
ATOM   2811 C  C   . THR A 1 428 ? 124.398 116.546 102.165 1.00 57.91  ? 428 THR A C   1 
ATOM   2812 O  O   . THR A 1 428 ? 125.243 116.644 101.267 1.00 58.92  ? 428 THR A O   1 
ATOM   2813 C  CB  . THR A 1 428 ? 125.073 115.667 104.417 1.00 58.67  ? 428 THR A CB  1 
ATOM   2814 O  OG1 . THR A 1 428 ? 125.716 116.047 105.640 1.00 67.86  ? 428 THR A OG1 1 
ATOM   2815 C  CG2 . THR A 1 428 ? 125.990 114.737 103.643 1.00 57.69  ? 428 THR A CG2 1 
ATOM   2816 N  N   . ALA A 1 429 ? 123.156 116.119 101.928 1.00 68.45  ? 429 ALA A N   1 
ATOM   2817 C  CA  . ALA A 1 429 ? 122.745 115.748 100.578 1.00 64.01  ? 429 ALA A CA  1 
ATOM   2818 C  C   . ALA A 1 429 ? 122.806 116.943 99.636  1.00 57.89  ? 429 ALA A C   1 
ATOM   2819 O  O   . ALA A 1 429 ? 123.293 116.830 98.506  1.00 58.63  ? 429 ALA A O   1 
ATOM   2820 C  CB  . ALA A 1 429 ? 121.340 115.150 100.604 1.00 57.58  ? 429 ALA A CB  1 
ATOM   2821 N  N   . ILE A 1 430 ? 122.327 118.105 100.089 1.00 60.44  ? 430 ILE A N   1 
ATOM   2822 C  CA  . ILE A 1 430 ? 122.375 119.300 99.248  1.00 59.96  ? 430 ILE A CA  1 
ATOM   2823 C  C   . ILE A 1 430 ? 123.821 119.675 98.940  1.00 59.96  ? 430 ILE A C   1 
ATOM   2824 O  O   . ILE A 1 430 ? 124.177 119.968 97.789  1.00 63.99  ? 430 ILE A O   1 
ATOM   2825 C  CB  . ILE A 1 430 ? 121.623 120.464 99.918  1.00 63.46  ? 430 ILE A CB  1 
ATOM   2826 C  CG1 . ILE A 1 430 ? 120.118 120.202 99.922  1.00 60.97  ? 430 ILE A CG1 1 
ATOM   2827 C  CG2 . ILE A 1 430 ? 121.927 121.775 99.210  1.00 57.90  ? 430 ILE A CG2 1 
ATOM   2828 C  CD1 . ILE A 1 430 ? 119.360 121.034 100.930 1.00 56.76  ? 430 ILE A CD1 1 
ATOM   2829 N  N   . VAL A 1 431 ? 124.679 119.657 99.965  1.00 73.43  ? 431 VAL A N   1 
ATOM   2830 C  CA  . VAL A 1 431 ? 126.073 120.052 99.775  1.00 70.38  ? 431 VAL A CA  1 
ATOM   2831 C  C   . VAL A 1 431 ? 126.767 119.114 98.795  1.00 72.05  ? 431 VAL A C   1 
ATOM   2832 O  O   . VAL A 1 431 ? 127.504 119.557 97.906  1.00 71.76  ? 431 VAL A O   1 
ATOM   2833 C  CB  . VAL A 1 431 ? 126.801 120.106 101.131 1.00 70.66  ? 431 VAL A CB  1 
ATOM   2834 C  CG1 . VAL A 1 431 ? 128.288 119.851 100.959 1.00 70.48  ? 431 VAL A CG1 1 
ATOM   2835 C  CG2 . VAL A 1 431 ? 126.565 121.448 101.801 1.00 70.66  ? 431 VAL A CG2 1 
ATOM   2836 N  N   . ASP A 1 432 ? 126.536 117.806 98.931  1.00 82.19  ? 432 ASP A N   1 
ATOM   2837 C  CA  . ASP A 1 432 ? 127.153 116.849 98.020  1.00 75.01  ? 432 ASP A CA  1 
ATOM   2838 C  C   . ASP A 1 432 ? 126.590 116.964 96.609  1.00 77.78  ? 432 ASP A C   1 
ATOM   2839 O  O   . ASP A 1 432 ? 127.318 116.739 95.635  1.00 77.91  ? 432 ASP A O   1 
ATOM   2840 C  CB  . ASP A 1 432 ? 126.969 115.427 98.547  1.00 74.77  ? 432 ASP A CB  1 
ATOM   2841 C  CG  . ASP A 1 432 ? 127.947 115.085 99.653  1.00 82.13  ? 432 ASP A CG  1 
ATOM   2842 O  OD1 . ASP A 1 432 ? 128.342 113.905 99.756  1.00 84.47  ? 432 ASP A OD1 1 
ATOM   2843 O  OD2 . ASP A 1 432 ? 128.322 115.997 100.419 1.00 81.53  ? 432 ASP A OD2 1 
ATOM   2844 N  N   . GLU A 1 433 ? 125.306 117.303 96.473  1.00 81.11  ? 433 GLU A N   1 
ATOM   2845 C  CA  . GLU A 1 433 ? 124.706 117.399 95.147  1.00 77.72  ? 433 GLU A CA  1 
ATOM   2846 C  C   . GLU A 1 433 ? 125.217 118.617 94.389  1.00 77.24  ? 433 GLU A C   1 
ATOM   2847 O  O   . GLU A 1 433 ? 125.468 118.543 93.181  1.00 81.15  ? 433 GLU A O   1 
ATOM   2848 C  CB  . GLU A 1 433 ? 123.184 117.436 95.256  1.00 75.92  ? 433 GLU A CB  1 
ATOM   2849 C  CG  . GLU A 1 433 ? 122.520 116.110 94.949  1.00 76.58  ? 433 GLU A CG  1 
ATOM   2850 C  CD  . GLU A 1 433 ? 122.749 115.667 93.519  1.00 83.77  ? 433 GLU A CD  1 
ATOM   2851 O  OE1 . GLU A 1 433 ? 122.280 116.365 92.597  1.00 85.02  ? 433 GLU A OE1 1 
ATOM   2852 O  OE2 . GLU A 1 433 ? 123.399 114.620 93.317  1.00 85.91  ? 433 GLU A OE2 1 
ATOM   2853 N  N   . VAL A 1 434 ? 125.361 119.755 95.074  1.00 80.44  ? 434 VAL A N   1 
ATOM   2854 C  CA  . VAL A 1 434 ? 125.837 120.958 94.391  1.00 79.12  ? 434 VAL A CA  1 
ATOM   2855 C  C   . VAL A 1 434 ? 127.242 120.733 93.840  1.00 83.68  ? 434 VAL A C   1 
ATOM   2856 O  O   . VAL A 1 434 ? 127.533 121.051 92.681  1.00 84.02  ? 434 VAL A O   1 
ATOM   2857 C  CB  . VAL A 1 434 ? 125.775 122.175 95.329  1.00 76.59  ? 434 VAL A CB  1 
ATOM   2858 C  CG1 . VAL A 1 434 ? 126.296 123.406 94.621  1.00 78.51  ? 434 VAL A CG1 1 
ATOM   2859 C  CG2 . VAL A 1 434 ? 124.348 122.408 95.784  1.00 78.73  ? 434 VAL A CG2 1 
ATOM   2860 N  N   . GLY A 1 435 ? 128.133 120.179 94.662  1.00 90.91  ? 435 GLY A N   1 
ATOM   2861 C  CA  . GLY A 1 435 ? 129.371 119.602 94.183  1.00 88.48  ? 435 GLY A CA  1 
ATOM   2862 C  C   . GLY A 1 435 ? 130.581 120.511 94.160  1.00 94.19  ? 435 GLY A C   1 
ATOM   2863 O  O   . GLY A 1 435 ? 131.709 120.003 94.117  1.00 94.10  ? 435 GLY A O   1 
ATOM   2864 N  N   . ASN A 1 436 ? 130.402 121.831 94.189  1.00 100.64 ? 436 ASN A N   1 
ATOM   2865 C  CA  . ASN A 1 436 ? 131.556 122.722 94.117  1.00 97.64  ? 436 ASN A CA  1 
ATOM   2866 C  C   . ASN A 1 436 ? 132.201 122.896 95.485  1.00 98.43  ? 436 ASN A C   1 
ATOM   2867 O  O   . ASN A 1 436 ? 131.750 122.308 96.473  1.00 98.21  ? 436 ASN A O   1 
ATOM   2868 C  CB  . ASN A 1 436 ? 131.164 124.088 93.547  1.00 96.65  ? 436 ASN A CB  1 
ATOM   2869 C  CG  . ASN A 1 436 ? 129.985 124.013 92.602  1.00 100.01 ? 436 ASN A CG  1 
ATOM   2870 O  OD1 . ASN A 1 436 ? 128.844 124.240 92.998  1.00 99.88  ? 436 ASN A OD1 1 
ATOM   2871 N  ND2 . ASN A 1 436 ? 130.255 123.696 91.342  1.00 100.25 ? 436 ASN A ND2 1 
ATOM   2872 N  N   . GLU A 1 437 ? 133.260 123.702 95.549  1.00 106.30 ? 437 GLU A N   1 
ATOM   2873 C  CA  . GLU A 1 437 ? 133.909 124.032 96.808  1.00 106.11 ? 437 GLU A CA  1 
ATOM   2874 C  C   . GLU A 1 437 ? 133.398 125.326 97.420  1.00 106.11 ? 437 GLU A C   1 
ATOM   2875 O  O   . GLU A 1 437 ? 133.648 125.568 98.607  1.00 106.03 ? 437 GLU A O   1 
ATOM   2876 C  CB  . GLU A 1 437 ? 135.436 124.133 96.635  1.00 104.36 ? 437 GLU A CB  1 
ATOM   2877 C  CG  . GLU A 1 437 ? 135.941 125.230 95.689  1.00 105.36 ? 437 GLU A CG  1 
ATOM   2878 C  CD  . GLU A 1 437 ? 135.429 125.101 94.267  1.00 107.39 ? 437 GLU A CD  1 
ATOM   2879 O  OE1 . GLU A 1 437 ? 135.196 126.144 93.620  1.00 107.46 ? 437 GLU A OE1 1 
ATOM   2880 O  OE2 . GLU A 1 437 ? 135.264 123.956 93.795  1.00 106.60 ? 437 GLU A OE2 1 
ATOM   2881 N  N   . TRP A 1 438 ? 132.695 126.162 96.654  1.00 98.80  ? 438 TRP A N   1 
ATOM   2882 C  CA  . TRP A 1 438 ? 132.090 127.364 97.212  1.00 98.14  ? 438 TRP A CA  1 
ATOM   2883 C  C   . TRP A 1 438 ? 130.883 127.036 98.081  1.00 98.79  ? 438 TRP A C   1 
ATOM   2884 O  O   . TRP A 1 438 ? 130.628 127.734 99.068  1.00 101.18 ? 438 TRP A O   1 
ATOM   2885 C  CB  . TRP A 1 438 ? 131.695 128.320 96.085  1.00 97.85  ? 438 TRP A CB  1 
ATOM   2886 C  CG  . TRP A 1 438 ? 130.916 129.518 96.534  1.00 100.28 ? 438 TRP A CG  1 
ATOM   2887 C  CD1 . TRP A 1 438 ? 131.421 130.731 96.897  1.00 101.13 ? 438 TRP A CD1 1 
ATOM   2888 C  CD2 . TRP A 1 438 ? 129.492 129.625 96.648  1.00 101.13 ? 438 TRP A CD2 1 
ATOM   2889 N  NE1 . TRP A 1 438 ? 130.401 131.585 97.240  1.00 100.12 ? 438 TRP A NE1 1 
ATOM   2890 C  CE2 . TRP A 1 438 ? 129.207 130.931 97.095  1.00 100.35 ? 438 TRP A CE2 1 
ATOM   2891 C  CE3 . TRP A 1 438 ? 128.431 128.744 96.421  1.00 99.16  ? 438 TRP A CE3 1 
ATOM   2892 C  CZ2 . TRP A 1 438 ? 127.906 131.375 97.319  1.00 100.13 ? 438 TRP A CZ2 1 
ATOM   2893 C  CZ3 . TRP A 1 438 ? 127.141 129.187 96.644  1.00 99.45  ? 438 TRP A CZ3 1 
ATOM   2894 C  CH2 . TRP A 1 438 ? 126.890 130.491 97.088  1.00 101.60 ? 438 TRP A CH2 1 
ATOM   2895 N  N   . ILE A 1 439 ? 130.134 125.988 97.733  1.00 91.84  ? 439 ILE A N   1 
ATOM   2896 C  CA  . ILE A 1 439 ? 129.006 125.577 98.562  1.00 91.49  ? 439 ILE A CA  1 
ATOM   2897 C  C   . ILE A 1 439 ? 129.485 124.818 99.791  1.00 95.71  ? 439 ILE A C   1 
ATOM   2898 O  O   . ILE A 1 439 ? 128.754 124.704 100.782 1.00 102.14 ? 439 ILE A O   1 
ATOM   2899 C  CB  . ILE A 1 439 ? 128.009 124.742 97.736  1.00 90.69  ? 439 ILE A CB  1 
ATOM   2900 C  CG1 . ILE A 1 439 ? 126.604 124.843 98.332  1.00 88.50  ? 439 ILE A CG1 1 
ATOM   2901 C  CG2 . ILE A 1 439 ? 128.456 123.291 97.660  1.00 92.09  ? 439 ILE A CG2 1 
ATOM   2902 C  CD1 . ILE A 1 439 ? 125.991 126.218 98.222  1.00 89.52  ? 439 ILE A CD1 1 
ATOM   2903 N  N   . LEU A 1 440 ? 130.707 124.282 99.755  1.00 86.37  ? 440 LEU A N   1 
ATOM   2904 C  CA  . LEU A 1 440 ? 131.251 123.593 100.918 1.00 85.83  ? 440 LEU A CA  1 
ATOM   2905 C  C   . LEU A 1 440 ? 131.711 124.566 101.995 1.00 90.24  ? 440 LEU A C   1 
ATOM   2906 O  O   . LEU A 1 440 ? 131.634 124.240 103.184 1.00 94.79  ? 440 LEU A O   1 
ATOM   2907 C  CB  . LEU A 1 440 ? 132.407 122.684 100.494 1.00 90.93  ? 440 LEU A CB  1 
ATOM   2908 C  CG  . LEU A 1 440 ? 133.332 122.139 101.585 1.00 92.04  ? 440 LEU A CG  1 
ATOM   2909 C  CD1 . LEU A 1 440 ? 132.605 121.116 102.442 1.00 88.14  ? 440 LEU A CD1 1 
ATOM   2910 C  CD2 . LEU A 1 440 ? 134.587 121.537 100.975 1.00 91.83  ? 440 LEU A CD2 1 
ATOM   2911 N  N   . GLN A 1 441 ? 132.170 125.754 101.609 1.00 93.90  ? 441 GLN A N   1 
ATOM   2912 C  CA  . GLN A 1 441 ? 132.620 126.764 102.556 1.00 95.43  ? 441 GLN A CA  1 
ATOM   2913 C  C   . GLN A 1 441 ? 131.478 127.599 103.119 1.00 96.77  ? 441 GLN A C   1 
ATOM   2914 O  O   . GLN A 1 441 ? 131.716 128.430 104.002 1.00 98.27  ? 441 GLN A O   1 
ATOM   2915 C  CB  . GLN A 1 441 ? 133.647 127.685 101.890 1.00 91.21  ? 441 GLN A CB  1 
ATOM   2916 C  CG  . GLN A 1 441 ? 135.084 127.217 102.033 1.00 94.93  ? 441 GLN A CG  1 
ATOM   2917 C  CD  . GLN A 1 441 ? 136.022 127.923 101.075 1.00 98.74  ? 441 GLN A CD  1 
ATOM   2918 O  OE1 . GLN A 1 441 ? 136.239 129.131 101.178 1.00 98.30  ? 441 GLN A OE1 1 
ATOM   2919 N  NE2 . GLN A 1 441 ? 136.583 127.172 100.134 1.00 97.61  ? 441 GLN A NE2 1 
ATOM   2920 N  N   . LYS A 1 442 ? 130.254 127.400 102.639 1.00 81.54  ? 442 LYS A N   1 
ATOM   2921 C  CA  . LYS A 1 442 ? 129.087 128.145 103.094 1.00 74.98  ? 442 LYS A CA  1 
ATOM   2922 C  C   . LYS A 1 442 ? 128.001 127.195 103.574 1.00 77.25  ? 442 LYS A C   1 
ATOM   2923 O  O   . LYS A 1 442 ? 126.817 127.371 103.279 1.00 84.07  ? 442 LYS A O   1 
ATOM   2924 C  CB  . LYS A 1 442 ? 128.558 129.056 101.990 1.00 73.06  ? 442 LYS A CB  1 
ATOM   2925 C  CG  . LYS A 1 442 ? 129.595 130.016 101.435 1.00 79.36  ? 442 LYS A CG  1 
ATOM   2926 C  CD  . LYS A 1 442 ? 129.073 131.441 101.406 1.00 83.36  ? 442 LYS A CD  1 
ATOM   2927 C  CE  . LYS A 1 442 ? 130.210 132.446 101.484 1.00 85.24  ? 442 LYS A CE  1 
ATOM   2928 N  NZ  . LYS A 1 442 ? 131.504 131.856 101.046 1.00 85.45  ? 442 LYS A NZ  1 
ATOM   2929 N  N   . LYS A 1 443 ? 128.396 126.166 104.325 1.00 65.52  ? 443 LYS A N   1 
ATOM   2930 C  CA  . LYS A 1 443 ? 127.443 125.190 104.841 1.00 68.90  ? 443 LYS A CA  1 
ATOM   2931 C  C   . LYS A 1 443 ? 126.554 125.777 105.932 1.00 71.41  ? 443 LYS A C   1 
ATOM   2932 O  O   . LYS A 1 443 ? 125.380 125.396 106.046 1.00 74.64  ? 443 LYS A O   1 
ATOM   2933 C  CB  . LYS A 1 443 ? 128.199 123.970 105.369 1.00 67.30  ? 443 LYS A CB  1 
ATOM   2934 C  CG  . LYS A 1 443 ? 127.339 122.755 105.639 1.00 68.59  ? 443 LYS A CG  1 
ATOM   2935 C  CD  . LYS A 1 443 ? 128.054 121.797 106.574 1.00 70.52  ? 443 LYS A CD  1 
ATOM   2936 C  CE  . LYS A 1 443 ? 127.503 120.389 106.453 1.00 76.19  ? 443 LYS A CE  1 
ATOM   2937 N  NZ  . LYS A 1 443 ? 128.151 119.468 107.425 1.00 82.62  ? 443 LYS A NZ  1 
ATOM   2938 N  N   . THR A 1 444 ? 127.091 126.699 106.734 1.00 62.44  ? 444 THR A N   1 
ATOM   2939 C  CA  . THR A 1 444 ? 126.306 127.311 107.801 1.00 60.41  ? 444 THR A CA  1 
ATOM   2940 C  C   . THR A 1 444 ? 125.133 128.104 107.237 1.00 62.91  ? 444 THR A C   1 
ATOM   2941 O  O   . THR A 1 444 ? 124.031 128.077 107.796 1.00 69.20  ? 444 THR A O   1 
ATOM   2942 C  CB  . THR A 1 444 ? 127.201 128.208 108.657 1.00 63.74  ? 444 THR A CB  1 
ATOM   2943 O  OG1 . THR A 1 444 ? 128.286 127.435 109.184 1.00 62.13  ? 444 THR A OG1 1 
ATOM   2944 C  CG2 . THR A 1 444 ? 126.414 128.809 109.808 1.00 63.81  ? 444 THR A CG2 1 
ATOM   2945 N  N   . TYR A 1 445 ? 125.351 128.818 106.131 1.00 58.65  ? 445 TYR A N   1 
ATOM   2946 C  CA  . TYR A 1 445 ? 124.262 129.564 105.507 1.00 57.81  ? 445 TYR A CA  1 
ATOM   2947 C  C   . TYR A 1 445 ? 123.187 128.628 104.967 1.00 61.05  ? 445 TYR A C   1 
ATOM   2948 O  O   . TYR A 1 445 ? 121.993 128.936 105.042 1.00 65.04  ? 445 TYR A O   1 
ATOM   2949 C  CB  . TYR A 1 445 ? 124.809 130.459 104.397 1.00 59.92  ? 445 TYR A CB  1 
ATOM   2950 C  CG  . TYR A 1 445 ? 125.666 131.597 104.902 1.00 62.39  ? 445 TYR A CG  1 
ATOM   2951 C  CD1 . TYR A 1 445 ? 125.566 132.037 106.214 1.00 62.41  ? 445 TYR A CD1 1 
ATOM   2952 C  CD2 . TYR A 1 445 ? 126.579 132.227 104.069 1.00 65.54  ? 445 TYR A CD2 1 
ATOM   2953 C  CE1 . TYR A 1 445 ? 126.347 133.075 106.680 1.00 63.31  ? 445 TYR A CE1 1 
ATOM   2954 C  CE2 . TYR A 1 445 ? 127.365 133.265 104.526 1.00 64.97  ? 445 TYR A CE2 1 
ATOM   2955 C  CZ  . TYR A 1 445 ? 127.245 133.685 105.832 1.00 67.39  ? 445 TYR A CZ  1 
ATOM   2956 O  OH  . TYR A 1 445 ? 128.026 134.720 106.292 1.00 73.18  ? 445 TYR A OH  1 
ATOM   2957 N  N   . VAL A 1 446 ? 123.590 127.481 104.417 1.00 53.35  ? 446 VAL A N   1 
ATOM   2958 C  CA  . VAL A 1 446 ? 122.616 126.499 103.948 1.00 50.18  ? 446 VAL A CA  1 
ATOM   2959 C  C   . VAL A 1 446 ? 121.786 125.973 105.113 1.00 56.28  ? 446 VAL A C   1 
ATOM   2960 O  O   . VAL A 1 446 ? 120.556 125.854 105.018 1.00 60.67  ? 446 VAL A O   1 
ATOM   2961 C  CB  . VAL A 1 446 ? 123.328 125.357 103.199 1.00 50.51  ? 446 VAL A CB  1 
ATOM   2962 C  CG1 . VAL A 1 446 ? 122.322 124.328 102.710 1.00 49.98  ? 446 VAL A CG1 1 
ATOM   2963 C  CG2 . VAL A 1 446 ? 124.140 125.909 102.041 1.00 47.48  ? 446 VAL A CG2 1 
ATOM   2964 N  N   . THR A 1 447 ? 122.445 125.651 106.231 1.00 51.07  ? 447 THR A N   1 
ATOM   2965 C  CA  . THR A 1 447 ? 121.718 125.183 107.408 1.00 51.81  ? 447 THR A CA  1 
ATOM   2966 C  C   . THR A 1 447 ? 120.757 126.248 107.922 1.00 56.23  ? 447 THR A C   1 
ATOM   2967 O  O   . THR A 1 447 ? 119.615 125.942 108.290 1.00 59.99  ? 447 THR A O   1 
ATOM   2968 C  CB  . THR A 1 447 ? 122.701 124.780 108.508 1.00 57.63  ? 447 THR A CB  1 
ATOM   2969 O  OG1 . THR A 1 447 ? 123.761 123.998 107.944 1.00 60.20  ? 447 THR A OG1 1 
ATOM   2970 C  CG2 . THR A 1 447 ? 121.994 123.966 109.579 1.00 60.09  ? 447 THR A CG2 1 
ATOM   2971 N  N   . LEU A 1 448 ? 121.204 127.505 107.953 1.00 42.07  ? 448 LEU A N   1 
ATOM   2972 C  CA  . LEU A 1 448 ? 120.347 128.596 108.405 1.00 43.75  ? 448 LEU A CA  1 
ATOM   2973 C  C   . LEU A 1 448 ? 119.137 128.761 107.496 1.00 48.83  ? 448 LEU A C   1 
ATOM   2974 O  O   . LEU A 1 448 ? 118.016 128.967 107.975 1.00 57.42  ? 448 LEU A O   1 
ATOM   2975 C  CB  . LEU A 1 448 ? 121.152 129.893 108.470 1.00 45.13  ? 448 LEU A CB  1 
ATOM   2976 C  CG  . LEU A 1 448 ? 120.419 131.166 108.894 1.00 48.20  ? 448 LEU A CG  1 
ATOM   2977 C  CD1 . LEU A 1 448 ? 119.796 130.997 110.267 1.00 50.74  ? 448 LEU A CD1 1 
ATOM   2978 C  CD2 . LEU A 1 448 ? 121.370 132.348 108.877 1.00 48.79  ? 448 LEU A CD2 1 
ATOM   2979 N  N   . GLY A 1 449 ? 119.343 128.676 106.181 1.00 41.63  ? 449 GLY A N   1 
ATOM   2980 C  CA  . GLY A 1 449 ? 118.226 128.781 105.258 1.00 38.10  ? 449 GLY A CA  1 
ATOM   2981 C  C   . GLY A 1 449 ? 117.222 127.658 105.425 1.00 41.50  ? 449 GLY A C   1 
ATOM   2982 O  O   . GLY A 1 449 ? 116.010 127.888 105.406 1.00 52.83  ? 449 GLY A O   1 
ATOM   2983 N  N   . VAL A 1 450 ? 117.711 126.427 105.597 1.00 34.89  ? 450 VAL A N   1 
ATOM   2984 C  CA  . VAL A 1 450 ? 116.806 125.297 105.803 1.00 39.05  ? 450 VAL A CA  1 
ATOM   2985 C  C   . VAL A 1 450 ? 116.012 125.474 107.094 1.00 42.50  ? 450 VAL A C   1 
ATOM   2986 O  O   . VAL A 1 450 ? 114.797 125.233 107.132 1.00 46.35  ? 450 VAL A O   1 
ATOM   2987 C  CB  . VAL A 1 450 ? 117.588 123.971 105.792 1.00 39.16  ? 450 VAL A CB  1 
ATOM   2988 C  CG1 . VAL A 1 450 ? 116.681 122.816 106.170 1.00 32.82  ? 450 VAL A CG1 1 
ATOM   2989 C  CG2 . VAL A 1 450 ? 118.196 123.730 104.424 1.00 39.87  ? 450 VAL A CG2 1 
ATOM   2990 N  N   . ALA A 1 451 ? 116.682 125.899 108.169 1.00 39.42  ? 451 ALA A N   1 
ATOM   2991 C  CA  . ALA A 1 451 ? 115.989 126.100 109.439 1.00 36.35  ? 451 ALA A CA  1 
ATOM   2992 C  C   . ALA A 1 451 ? 114.934 127.195 109.333 1.00 39.46  ? 451 ALA A C   1 
ATOM   2993 O  O   . ALA A 1 451 ? 113.821 127.048 109.852 1.00 46.27  ? 451 ALA A O   1 
ATOM   2994 C  CB  . ALA A 1 451 ? 116.996 126.430 110.539 1.00 35.15  ? 451 ALA A CB  1 
ATOM   2995 N  N   . VAL A 1 452 ? 115.265 128.303 108.664 1.00 35.62  ? 452 VAL A N   1 
ATOM   2996 C  CA  . VAL A 1 452 ? 114.309 129.398 108.518 1.00 31.37  ? 452 VAL A CA  1 
ATOM   2997 C  C   . VAL A 1 452 ? 113.114 128.957 107.682 1.00 41.74  ? 452 VAL A C   1 
ATOM   2998 O  O   . VAL A 1 452 ? 111.964 129.287 107.996 1.00 48.23  ? 452 VAL A O   1 
ATOM   2999 C  CB  . VAL A 1 452 ? 115.001 130.636 107.918 1.00 30.75  ? 452 VAL A CB  1 
ATOM   3000 C  CG1 . VAL A 1 452 ? 113.976 131.650 107.449 1.00 40.26  ? 452 VAL A CG1 1 
ATOM   3001 C  CG2 . VAL A 1 452 ? 115.932 131.262 108.937 1.00 36.06  ? 452 VAL A CG2 1 
ATOM   3002 N  N   . ALA A 1 453 ? 113.364 128.205 106.606 1.00 42.42  ? 453 ALA A N   1 
ATOM   3003 C  CA  . ALA A 1 453 ? 112.265 127.712 105.783 1.00 36.33  ? 453 ALA A CA  1 
ATOM   3004 C  C   . ALA A 1 453 ? 111.352 126.786 106.575 1.00 40.05  ? 453 ALA A C   1 
ATOM   3005 O  O   . ALA A 1 453 ? 110.122 126.885 106.480 1.00 37.25  ? 453 ALA A O   1 
ATOM   3006 C  CB  . ALA A 1 453 ? 112.814 126.998 104.548 1.00 34.38  ? 453 ALA A CB  1 
ATOM   3007 N  N   . GLY A 1 454 ? 111.934 125.883 107.368 1.00 44.83  ? 454 GLY A N   1 
ATOM   3008 C  CA  . GLY A 1 454 ? 111.116 125.003 108.190 1.00 29.36  ? 454 GLY A CA  1 
ATOM   3009 C  C   . GLY A 1 454 ? 110.295 125.759 109.217 1.00 34.41  ? 454 GLY A C   1 
ATOM   3010 O  O   . GLY A 1 454 ? 109.110 125.470 109.416 1.00 43.07  ? 454 GLY A O   1 
ATOM   3011 N  N   . PHE A 1 455 ? 110.908 126.746 109.875 1.00 29.21  ? 455 PHE A N   1 
ATOM   3012 C  CA  . PHE A 1 455 ? 110.177 127.547 110.851 1.00 29.92  ? 455 PHE A CA  1 
ATOM   3013 C  C   . PHE A 1 455 ? 109.028 128.304 110.199 1.00 39.53  ? 455 PHE A C   1 
ATOM   3014 O  O   . PHE A 1 455 ? 107.924 128.363 110.750 1.00 37.20  ? 455 PHE A O   1 
ATOM   3015 C  CB  . PHE A 1 455 ? 111.126 128.521 111.551 1.00 35.24  ? 455 PHE A CB  1 
ATOM   3016 C  CG  . PHE A 1 455 ? 110.426 129.541 112.402 1.00 38.31  ? 455 PHE A CG  1 
ATOM   3017 C  CD1 . PHE A 1 455 ? 109.824 129.175 113.592 1.00 36.75  ? 455 PHE A CD1 1 
ATOM   3018 C  CD2 . PHE A 1 455 ? 110.368 130.867 112.011 1.00 36.93  ? 455 PHE A CD2 1 
ATOM   3019 C  CE1 . PHE A 1 455 ? 109.179 130.110 114.375 1.00 38.73  ? 455 PHE A CE1 1 
ATOM   3020 C  CE2 . PHE A 1 455 ? 109.723 131.806 112.790 1.00 33.76  ? 455 PHE A CE2 1 
ATOM   3021 C  CZ  . PHE A 1 455 ? 109.129 131.427 113.973 1.00 33.77  ? 455 PHE A CZ  1 
ATOM   3022 N  N   . LEU A 1 456 ? 109.268 128.889 109.023 1.00 43.23  ? 456 LEU A N   1 
ATOM   3023 C  CA  . LEU A 1 456 ? 108.214 129.634 108.340 1.00 29.36  ? 456 LEU A CA  1 
ATOM   3024 C  C   . LEU A 1 456 ? 107.087 128.715 107.890 1.00 31.20  ? 456 LEU A C   1 
ATOM   3025 O  O   . LEU A 1 456 ? 105.911 129.091 107.956 1.00 43.80  ? 456 LEU A O   1 
ATOM   3026 C  CB  . LEU A 1 456 ? 108.793 130.396 107.150 1.00 34.06  ? 456 LEU A CB  1 
ATOM   3027 C  CG  . LEU A 1 456 ? 109.518 131.702 107.472 1.00 39.61  ? 456 LEU A CG  1 
ATOM   3028 C  CD1 . LEU A 1 456 ? 110.241 132.225 106.244 1.00 31.94  ? 456 LEU A CD1 1 
ATOM   3029 C  CD2 . LEU A 1 456 ? 108.545 132.738 108.006 1.00 39.57  ? 456 LEU A CD2 1 
ATOM   3030 N  N   . LEU A 1 457 ? 107.420 127.510 107.423 1.00 38.26  ? 457 LEU A N   1 
ATOM   3031 C  CA  . LEU A 1 457 ? 106.380 126.587 106.981 1.00 35.09  ? 457 LEU A CA  1 
ATOM   3032 C  C   . LEU A 1 457 ? 105.597 126.009 108.154 1.00 42.04  ? 457 LEU A C   1 
ATOM   3033 O  O   . LEU A 1 457 ? 104.443 125.603 107.983 1.00 41.16  ? 457 LEU A O   1 
ATOM   3034 C  CB  . LEU A 1 457 ? 106.992 125.464 106.145 1.00 36.30  ? 457 LEU A CB  1 
ATOM   3035 C  CG  . LEU A 1 457 ? 107.373 125.831 104.709 1.00 35.23  ? 457 LEU A CG  1 
ATOM   3036 C  CD1 . LEU A 1 457 ? 108.304 124.790 104.115 1.00 38.12  ? 457 LEU A CD1 1 
ATOM   3037 C  CD2 . LEU A 1 457 ? 106.134 125.994 103.849 1.00 35.58  ? 457 LEU A CD2 1 
ATOM   3038 N  N   . GLY A 1 458 ? 106.197 125.960 109.344 1.00 49.67  ? 458 GLY A N   1 
ATOM   3039 C  CA  . GLY A 1 458 ? 105.480 125.440 110.496 1.00 34.32  ? 458 GLY A CA  1 
ATOM   3040 C  C   . GLY A 1 458 ? 104.534 126.407 111.182 1.00 33.68  ? 458 GLY A C   1 
ATOM   3041 O  O   . GLY A 1 458 ? 103.827 125.998 112.106 1.00 40.74  ? 458 GLY A O   1 
ATOM   3042 N  N   . ILE A 1 459 ? 104.506 127.675 110.760 1.00 40.47  ? 459 ILE A N   1 
ATOM   3043 C  CA  . ILE A 1 459 ? 103.650 128.663 111.425 1.00 39.55  ? 459 ILE A CA  1 
ATOM   3044 C  C   . ILE A 1 459 ? 102.163 128.340 111.303 1.00 43.69  ? 459 ILE A C   1 
ATOM   3045 O  O   . ILE A 1 459 ? 101.454 128.420 112.320 1.00 41.81  ? 459 ILE A O   1 
ATOM   3046 C  CB  . ILE A 1 459 ? 103.991 130.078 110.928 1.00 40.95  ? 459 ILE A CB  1 
ATOM   3047 C  CG1 . ILE A 1 459 ? 105.448 130.417 111.243 1.00 41.86  ? 459 ILE A CG1 1 
ATOM   3048 C  CG2 . ILE A 1 459 ? 103.055 131.105 111.545 1.00 35.52  ? 459 ILE A CG2 1 
ATOM   3049 C  CD1 . ILE A 1 459 ? 105.783 131.882 111.092 1.00 42.55  ? 459 ILE A CD1 1 
ATOM   3050 N  N   . PRO A 1 460 ? 101.623 127.992 110.127 1.00 48.58  ? 460 PRO A N   1 
ATOM   3051 C  CA  . PRO A 1 460 ? 100.175 127.724 110.046 1.00 45.30  ? 460 PRO A CA  1 
ATOM   3052 C  C   . PRO A 1 460 ? 99.707  126.524 110.858 1.00 43.31  ? 460 PRO A C   1 
ATOM   3053 O  O   . PRO A 1 460 ? 98.493  126.326 110.982 1.00 42.88  ? 460 PRO A O   1 
ATOM   3054 C  CB  . PRO A 1 460 ? 99.938  127.501 108.545 1.00 34.95  ? 460 PRO A CB  1 
ATOM   3055 C  CG  . PRO A 1 460 ? 101.270 127.181 107.987 1.00 40.46  ? 460 PRO A CG  1 
ATOM   3056 C  CD  . PRO A 1 460 ? 102.233 127.987 108.786 1.00 39.43  ? 460 PRO A CD  1 
ATOM   3057 N  N   . LEU A 1 461 ? 100.614 125.723 111.409 1.00 42.74  ? 461 LEU A N   1 
ATOM   3058 C  CA  . LEU A 1 461 ? 100.240 124.589 112.243 1.00 36.65  ? 461 LEU A CA  1 
ATOM   3059 C  C   . LEU A 1 461 ? 100.078 124.962 113.711 1.00 42.22  ? 461 LEU A C   1 
ATOM   3060 O  O   . LEU A 1 461 ? 99.776  124.086 114.527 1.00 48.15  ? 461 LEU A O   1 
ATOM   3061 C  CB  . LEU A 1 461 ? 101.276 123.469 112.107 1.00 42.54  ? 461 LEU A CB  1 
ATOM   3062 C  CG  . LEU A 1 461 ? 100.985 122.381 111.072 1.00 37.73  ? 461 LEU A CG  1 
ATOM   3063 C  CD1 . LEU A 1 461 ? 101.150 122.917 109.664 1.00 39.95  ? 461 LEU A CD1 1 
ATOM   3064 C  CD2 . LEU A 1 461 ? 101.891 121.185 111.293 1.00 37.42  ? 461 LEU A CD2 1 
ATOM   3065 N  N   . THR A 1 462 ? 100.271 126.232 114.067 1.00 49.99  ? 462 THR A N   1 
ATOM   3066 C  CA  . THR A 1 462 ? 100.098 126.707 115.434 1.00 46.23  ? 462 THR A CA  1 
ATOM   3067 C  C   . THR A 1 462 ? 98.852  127.571 115.592 1.00 44.70  ? 462 THR A C   1 
ATOM   3068 O  O   . THR A 1 462 ? 98.759  128.350 116.544 1.00 46.58  ? 462 THR A O   1 
ATOM   3069 C  CB  . THR A 1 462 ? 101.334 127.481 115.894 1.00 45.88  ? 462 THR A CB  1 
ATOM   3070 O  OG1 . THR A 1 462 ? 101.378 128.750 115.231 1.00 50.58  ? 462 THR A OG1 1 
ATOM   3071 C  CG2 . THR A 1 462 ? 102.602 126.703 115.581 1.00 44.43  ? 462 THR A CG2 1 
ATOM   3072 N  N   . SER A 1 463 ? 97.898  127.457 114.674 1.00 49.64  ? 463 SER A N   1 
ATOM   3073 C  CA  . SER A 1 463 ? 96.656  128.208 114.748 1.00 52.30  ? 463 SER A CA  1 
ATOM   3074 C  C   . SER A 1 463 ? 95.605  127.384 115.490 1.00 56.77  ? 463 SER A C   1 
ATOM   3075 O  O   . SER A 1 463 ? 95.904  126.348 116.088 1.00 59.47  ? 463 SER A O   1 
ATOM   3076 C  CB  . SER A 1 463 ? 96.189  128.597 113.348 1.00 49.18  ? 463 SER A CB  1 
ATOM   3077 O  OG  . SER A 1 463 ? 96.490  127.580 112.411 1.00 55.24  ? 463 SER A OG  1 
ATOM   3078 N  N   . GLN A 1 464 ? 94.352  127.843 115.463 1.00 52.33  ? 464 GLN A N   1 
ATOM   3079 C  CA  . GLN A 1 464 ? 93.268  127.092 116.081 1.00 50.09  ? 464 GLN A CA  1 
ATOM   3080 C  C   . GLN A 1 464 ? 92.853  125.877 115.262 1.00 52.66  ? 464 GLN A C   1 
ATOM   3081 O  O   . GLN A 1 464 ? 92.158  125.004 115.790 1.00 60.36  ? 464 GLN A O   1 
ATOM   3082 C  CB  . GLN A 1 464 ? 92.060  128.001 116.308 1.00 46.08  ? 464 GLN A CB  1 
ATOM   3083 C  CG  . GLN A 1 464 ? 92.321  129.146 117.269 1.00 46.26  ? 464 GLN A CG  1 
ATOM   3084 C  CD  . GLN A 1 464 ? 91.044  129.741 117.820 1.00 52.33  ? 464 GLN A CD  1 
ATOM   3085 O  OE1 . GLN A 1 464 ? 90.952  130.946 118.040 1.00 58.23  ? 464 GLN A OE1 1 
ATOM   3086 N  NE2 . GLN A 1 464 ? 90.049  128.895 118.049 1.00 58.61  ? 464 GLN A NE2 1 
ATOM   3087 N  N   . ALA A 1 465 ? 93.257  125.801 113.994 1.00 52.78  ? 465 ALA A N   1 
ATOM   3088 C  CA  . ALA A 1 465 ? 92.985  124.652 113.141 1.00 49.65  ? 465 ALA A CA  1 
ATOM   3089 C  C   . ALA A 1 465 ? 94.253  123.877 112.805 1.00 48.87  ? 465 ALA A C   1 
ATOM   3090 O  O   . ALA A 1 465 ? 94.321  123.231 111.756 1.00 58.00  ? 465 ALA A O   1 
ATOM   3091 C  CB  . ALA A 1 465 ? 92.283  125.097 111.859 1.00 43.56  ? 465 ALA A CB  1 
ATOM   3092 N  N   . GLY A 1 466 ? 95.262  123.934 113.675 1.00 48.20  ? 466 GLY A N   1 
ATOM   3093 C  CA  . GLY A 1 466 ? 96.542  123.328 113.355 1.00 46.69  ? 466 GLY A CA  1 
ATOM   3094 C  C   . GLY A 1 466 ? 96.565  121.821 113.499 1.00 43.95  ? 466 GLY A C   1 
ATOM   3095 O  O   . GLY A 1 466 ? 97.306  121.142 112.784 1.00 54.66  ? 466 GLY A O   1 
ATOM   3096 N  N   . ILE A 1 467 ? 95.772  121.274 114.423 1.00 39.89  ? 467 ILE A N   1 
ATOM   3097 C  CA  . ILE A 1 467 ? 95.821  119.834 114.655 1.00 47.76  ? 467 ILE A CA  1 
ATOM   3098 C  C   . ILE A 1 467 ? 95.216  119.074 113.480 1.00 49.62  ? 467 ILE A C   1 
ATOM   3099 O  O   . ILE A 1 467 ? 95.623  117.942 113.193 1.00 54.37  ? 467 ILE A O   1 
ATOM   3100 C  CB  . ILE A 1 467 ? 95.144  119.475 115.993 1.00 47.91  ? 467 ILE A CB  1 
ATOM   3101 C  CG1 . ILE A 1 467 ? 95.847  118.279 116.636 1.00 46.63  ? 467 ILE A CG1 1 
ATOM   3102 C  CG2 . ILE A 1 467 ? 93.672  119.162 115.805 1.00 47.54  ? 467 ILE A CG2 1 
ATOM   3103 C  CD1 . ILE A 1 467 ? 97.153  118.631 117.308 1.00 46.80  ? 467 ILE A CD1 1 
ATOM   3104 N  N   . TYR A 1 468 ? 94.252  119.674 112.777 1.00 46.09  ? 468 TYR A N   1 
ATOM   3105 C  CA  . TYR A 1 468 ? 93.717  119.047 111.574 1.00 37.64  ? 468 TYR A CA  1 
ATOM   3106 C  C   . TYR A 1 468 ? 94.781  118.947 110.490 1.00 43.67  ? 468 TYR A C   1 
ATOM   3107 O  O   . TYR A 1 468 ? 94.935  117.898 109.851 1.00 49.40  ? 468 TYR A O   1 
ATOM   3108 C  CB  . TYR A 1 468 ? 92.511  119.836 111.065 1.00 45.04  ? 468 TYR A CB  1 
ATOM   3109 C  CG  . TYR A 1 468 ? 91.390  119.979 112.068 1.00 48.07  ? 468 TYR A CG  1 
ATOM   3110 C  CD1 . TYR A 1 468 ? 90.724  118.866 112.558 1.00 47.91  ? 468 TYR A CD1 1 
ATOM   3111 C  CD2 . TYR A 1 468 ? 90.993  121.229 112.519 1.00 48.42  ? 468 TYR A CD2 1 
ATOM   3112 C  CE1 . TYR A 1 468 ? 89.697  118.994 113.471 1.00 49.89  ? 468 TYR A CE1 1 
ATOM   3113 C  CE2 . TYR A 1 468 ? 89.967  121.367 113.432 1.00 47.22  ? 468 TYR A CE2 1 
ATOM   3114 C  CZ  . TYR A 1 468 ? 89.322  120.247 113.904 1.00 51.90  ? 468 TYR A CZ  1 
ATOM   3115 O  OH  . TYR A 1 468 ? 88.300  120.380 114.814 1.00 48.90  ? 468 TYR A OH  1 
ATOM   3116 N  N   . TRP A 1 469 ? 95.532  120.029 110.275 1.00 43.43  ? 469 TRP A N   1 
ATOM   3117 C  CA  . TRP A 1 469 ? 96.602  120.012 109.283 1.00 38.42  ? 469 TRP A CA  1 
ATOM   3118 C  C   . TRP A 1 469 ? 97.706  119.044 109.682 1.00 42.92  ? 469 TRP A C   1 
ATOM   3119 O  O   . TRP A 1 469 ? 98.267  118.344 108.832 1.00 46.85  ? 469 TRP A O   1 
ATOM   3120 C  CB  . TRP A 1 469 ? 97.164  121.421 109.098 1.00 34.55  ? 469 TRP A CB  1 
ATOM   3121 C  CG  . TRP A 1 469 ? 96.266  122.327 108.317 1.00 44.65  ? 469 TRP A CG  1 
ATOM   3122 C  CD1 . TRP A 1 469 ? 95.503  123.345 108.806 1.00 45.71  ? 469 TRP A CD1 1 
ATOM   3123 C  CD2 . TRP A 1 469 ? 96.038  122.300 106.903 1.00 49.35  ? 469 TRP A CD2 1 
ATOM   3124 N  NE1 . TRP A 1 469 ? 94.813  123.953 107.787 1.00 46.21  ? 469 TRP A NE1 1 
ATOM   3125 C  CE2 . TRP A 1 469 ? 95.125  123.329 106.608 1.00 52.04  ? 469 TRP A CE2 1 
ATOM   3126 C  CE3 . TRP A 1 469 ? 96.518  121.505 105.859 1.00 42.41  ? 469 TRP A CE3 1 
ATOM   3127 C  CZ2 . TRP A 1 469 ? 94.681  123.584 105.313 1.00 46.77  ? 469 TRP A CZ2 1 
ATOM   3128 C  CZ3 . TRP A 1 469 ? 96.077  121.759 104.575 1.00 43.93  ? 469 TRP A CZ3 1 
ATOM   3129 C  CH2 . TRP A 1 469 ? 95.167  122.790 104.313 1.00 44.03  ? 469 TRP A CH2 1 
ATOM   3130 N  N   . LEU A 1 470 ? 98.038  118.996 110.974 1.00 41.41  ? 470 LEU A N   1 
ATOM   3131 C  CA  . LEU A 1 470 ? 99.052  118.058 111.443 1.00 40.21  ? 470 LEU A CA  1 
ATOM   3132 C  C   . LEU A 1 470 ? 98.611  116.617 111.226 1.00 43.41  ? 470 LEU A C   1 
ATOM   3133 O  O   . LEU A 1 470 ? 99.406  115.776 110.794 1.00 55.75  ? 470 LEU A O   1 
ATOM   3134 C  CB  . LEU A 1 470 ? 99.358  118.313 112.919 1.00 41.53  ? 470 LEU A CB  1 
ATOM   3135 C  CG  . LEU A 1 470 ? 100.525 117.530 113.521 1.00 50.34  ? 470 LEU A CG  1 
ATOM   3136 C  CD1 . LEU A 1 470 ? 101.466 118.468 114.257 1.00 50.76  ? 470 LEU A CD1 1 
ATOM   3137 C  CD2 . LEU A 1 470 ? 100.025 116.437 114.450 1.00 45.96  ? 470 LEU A CD2 1 
ATOM   3138 N  N   . LEU A 1 471 ? 97.343  116.314 111.515 1.00 39.69  ? 471 LEU A N   1 
ATOM   3139 C  CA  . LEU A 1 471 ? 96.830  114.963 111.307 1.00 42.37  ? 471 LEU A CA  1 
ATOM   3140 C  C   . LEU A 1 471 ? 96.838  114.597 109.826 1.00 45.40  ? 471 LEU A C   1 
ATOM   3141 O  O   . LEU A 1 471 ? 97.200  113.470 109.452 1.00 49.52  ? 471 LEU A O   1 
ATOM   3142 C  CB  . LEU A 1 471 ? 95.421  114.865 111.892 1.00 41.95  ? 471 LEU A CB  1 
ATOM   3143 C  CG  . LEU A 1 471 ? 94.604  113.578 111.795 1.00 49.41  ? 471 LEU A CG  1 
ATOM   3144 C  CD1 . LEU A 1 471 ? 95.256  112.478 112.608 1.00 45.09  ? 471 LEU A CD1 1 
ATOM   3145 C  CD2 . LEU A 1 471 ? 93.183  113.821 112.269 1.00 51.96  ? 471 LEU A CD2 1 
ATOM   3146 N  N   . LEU A 1 472 ? 96.443  115.544 108.968 1.00 42.35  ? 472 LEU A N   1 
ATOM   3147 C  CA  . LEU A 1 472 ? 96.473  115.315 107.527 1.00 33.11  ? 472 LEU A CA  1 
ATOM   3148 C  C   . LEU A 1 472 ? 97.889  115.040 107.040 1.00 37.61  ? 472 LEU A C   1 
ATOM   3149 O  O   . LEU A 1 472 ? 98.114  114.113 106.258 1.00 41.79  ? 472 LEU A O   1 
ATOM   3150 C  CB  . LEU A 1 472 ? 95.882  116.522 106.798 1.00 37.93  ? 472 LEU A CB  1 
ATOM   3151 C  CG  . LEU A 1 472 ? 95.538  116.380 105.315 1.00 38.71  ? 472 LEU A CG  1 
ATOM   3152 C  CD1 . LEU A 1 472 ? 94.204  115.679 105.143 1.00 45.05  ? 472 LEU A CD1 1 
ATOM   3153 C  CD2 . LEU A 1 472 ? 95.524  117.735 104.629 1.00 37.64  ? 472 LEU A CD2 1 
ATOM   3154 N  N   . MET A 1 473 ? 98.859  115.835 107.494 1.00 43.09  ? 473 MET A N   1 
ATOM   3155 C  CA  . MET A 1 473 ? 100.247 115.607 107.104 1.00 35.50  ? 473 MET A CA  1 
ATOM   3156 C  C   . MET A 1 473 ? 100.747 114.263 107.614 1.00 41.88  ? 473 MET A C   1 
ATOM   3157 O  O   . MET A 1 473 ? 101.505 113.571 106.926 1.00 44.60  ? 473 MET A O   1 
ATOM   3158 C  CB  . MET A 1 473 ? 101.131 116.738 107.627 1.00 38.89  ? 473 MET A CB  1 
ATOM   3159 C  CG  . MET A 1 473 ? 101.015 118.038 106.854 1.00 43.78  ? 473 MET A CG  1 
ATOM   3160 S  SD  . MET A 1 473 ? 102.127 119.312 107.475 1.00 60.44  ? 473 MET A SD  1 
ATOM   3161 C  CE  . MET A 1 473 ? 103.587 118.994 106.491 1.00 38.68  ? 473 MET A CE  1 
ATOM   3162 N  N   . ASP A 1 474 ? 100.341 113.884 108.827 1.00 45.44  ? 474 ASP A N   1 
ATOM   3163 C  CA  . ASP A 1 474 ? 100.841 112.658 109.435 1.00 33.27  ? 474 ASP A CA  1 
ATOM   3164 C  C   . ASP A 1 474 ? 100.344 111.423 108.693 1.00 43.60  ? 474 ASP A C   1 
ATOM   3165 O  O   . ASP A 1 474 ? 101.129 110.522 108.378 1.00 55.18  ? 474 ASP A O   1 
ATOM   3166 C  CB  . ASP A 1 474 ? 100.436 112.612 110.909 1.00 45.65  ? 474 ASP A CB  1 
ATOM   3167 C  CG  . ASP A 1 474 ? 101.048 111.439 111.649 1.00 54.04  ? 474 ASP A CG  1 
ATOM   3168 O  OD1 . ASP A 1 474 ? 102.292 111.349 111.692 1.00 54.22  ? 474 ASP A OD1 1 
ATOM   3169 O  OD2 . ASP A 1 474 ? 100.289 110.614 112.199 1.00 47.76  ? 474 ASP A OD2 1 
ATOM   3170 N  N   . ASN A 1 475 ? 99.046  111.353 108.406 1.00 42.96  ? 475 ASN A N   1 
ATOM   3171 C  CA  . ASN A 1 475 ? 98.474  110.109 107.881 1.00 47.21  ? 475 ASN A CA  1 
ATOM   3172 C  C   . ASN A 1 475 ? 98.132  110.208 106.394 1.00 49.93  ? 475 ASN A C   1 
ATOM   3173 O  O   . ASN A 1 475 ? 97.333  109.431 105.876 1.00 59.10  ? 475 ASN A O   1 
ATOM   3174 C  CB  . ASN A 1 475 ? 97.247  109.708 108.697 1.00 40.15  ? 475 ASN A CB  1 
ATOM   3175 C  CG  . ASN A 1 475 ? 97.522  109.681 110.184 1.00 56.11  ? 475 ASN A CG  1 
ATOM   3176 O  OD1 . ASN A 1 475 ? 96.951  110.455 110.945 1.00 62.79  ? 475 ASN A OD1 1 
ATOM   3177 N  ND2 . ASN A 1 475 ? 98.392  108.772 110.609 1.00 60.78  ? 475 ASN A ND2 1 
ATOM   3178 N  N   . TYR A 1 476 ? 98.740  111.161 105.690 1.00 50.75  ? 476 TYR A N   1 
ATOM   3179 C  CA  . TYR A 1 476 ? 98.584  111.205 104.239 1.00 42.66  ? 476 TYR A CA  1 
ATOM   3180 C  C   . TYR A 1 476 ? 99.917  111.341 103.513 1.00 45.22  ? 476 TYR A C   1 
ATOM   3181 O  O   . TYR A 1 476 ? 100.122 110.731 102.459 1.00 53.18  ? 476 TYR A O   1 
ATOM   3182 C  CB  . TYR A 1 476 ? 97.654  112.350 103.834 1.00 42.99  ? 476 TYR A CB  1 
ATOM   3183 C  CG  . TYR A 1 476 ? 96.246  111.920 103.492 1.00 46.78  ? 476 TYR A CG  1 
ATOM   3184 C  CD1 . TYR A 1 476 ? 96.008  110.972 102.513 1.00 49.96  ? 476 TYR A CD1 1 
ATOM   3185 C  CD2 . TYR A 1 476 ? 95.155  112.459 104.160 1.00 49.28  ? 476 TYR A CD2 1 
ATOM   3186 C  CE1 . TYR A 1 476 ? 94.725  110.580 102.197 1.00 53.98  ? 476 TYR A CE1 1 
ATOM   3187 C  CE2 . TYR A 1 476 ? 93.868  112.071 103.851 1.00 46.23  ? 476 TYR A CE2 1 
ATOM   3188 C  CZ  . TYR A 1 476 ? 93.659  111.133 102.870 1.00 54.04  ? 476 TYR A CZ  1 
ATOM   3189 O  OH  . TYR A 1 476 ? 92.378  110.744 102.562 1.00 65.37  ? 476 TYR A OH  1 
ATOM   3190 N  N   . ALA A 1 477 ? 100.834 112.128 104.073 1.00 40.35  ? 477 ALA A N   1 
ATOM   3191 C  CA  . ALA A 1 477 ? 102.077 112.442 103.381 1.00 45.67  ? 477 ALA A CA  1 
ATOM   3192 C  C   . ALA A 1 477 ? 103.216 111.496 103.733 1.00 55.46  ? 477 ALA A C   1 
ATOM   3193 O  O   . ALA A 1 477 ? 104.133 111.328 102.922 1.00 57.20  ? 477 ALA A O   1 
ATOM   3194 C  CB  . ALA A 1 477 ? 102.500 113.881 103.684 1.00 41.60  ? 477 ALA A CB  1 
ATOM   3195 N  N   . ALA A 1 478 ? 103.190 110.884 104.917 1.00 52.77  ? 478 ALA A N   1 
ATOM   3196 C  CA  . ALA A 1 478 ? 104.297 110.060 105.395 1.00 46.76  ? 478 ALA A CA  1 
ATOM   3197 C  C   . ALA A 1 478 ? 103.767 108.745 105.967 1.00 51.17  ? 478 ALA A C   1 
ATOM   3198 O  O   . ALA A 1 478 ? 104.151 108.317 107.054 1.00 58.32  ? 478 ALA A O   1 
ATOM   3199 C  CB  . ALA A 1 478 ? 105.123 110.806 106.438 1.00 41.34  ? 478 ALA A CB  1 
ATOM   3200 N  N   . SER A 1 479 ? 102.872 108.094 105.225 1.00 48.55  ? 479 SER A N   1 
ATOM   3201 C  CA  . SER A 1 479 ? 102.333 106.824 105.693 1.00 47.23  ? 479 SER A CA  1 
ATOM   3202 C  C   . SER A 1 479 ? 102.722 105.656 104.794 1.00 52.14  ? 479 SER A C   1 
ATOM   3203 O  O   . SER A 1 479 ? 103.417 104.738 105.235 1.00 61.72  ? 479 SER A O   1 
ATOM   3204 C  CB  . SER A 1 479 ? 100.811 106.912 105.804 1.00 54.94  ? 479 SER A CB  1 
ATOM   3205 O  OG  . SER A 1 479 ? 100.225 107.172 104.542 1.00 63.73  ? 479 SER A OG  1 
ATOM   3206 N  N   . PHE A 1 480 ? 102.317 105.691 103.525 1.00 54.19  ? 480 PHE A N   1 
ATOM   3207 C  CA  . PHE A 1 480 ? 102.482 104.545 102.641 1.00 46.99  ? 480 PHE A CA  1 
ATOM   3208 C  C   . PHE A 1 480 ? 103.378 104.838 101.446 1.00 54.72  ? 480 PHE A C   1 
ATOM   3209 O  O   . PHE A 1 480 ? 103.593 103.950 100.614 1.00 59.33  ? 480 PHE A O   1 
ATOM   3210 C  CB  . PHE A 1 480 ? 101.118 104.042 102.165 1.00 41.05  ? 480 PHE A CB  1 
ATOM   3211 C  CG  . PHE A 1 480 ? 101.087 102.571 101.867 1.00 57.29  ? 480 PHE A CG  1 
ATOM   3212 C  CD1 . PHE A 1 480 ? 101.245 101.641 102.881 1.00 57.06  ? 480 PHE A CD1 1 
ATOM   3213 C  CD2 . PHE A 1 480 ? 100.908 102.118 100.571 1.00 57.86  ? 480 PHE A CD2 1 
ATOM   3214 C  CE1 . PHE A 1 480 ? 101.222 100.286 102.608 1.00 52.06  ? 480 PHE A CE1 1 
ATOM   3215 C  CE2 . PHE A 1 480 ? 100.885 100.765 100.291 1.00 54.79  ? 480 PHE A CE2 1 
ATOM   3216 C  CZ  . PHE A 1 480 ? 101.043 99.849  101.311 1.00 55.09  ? 480 PHE A CZ  1 
ATOM   3217 N  N   . SER A 1 481 ? 103.903 106.055 101.338 1.00 55.76  ? 481 SER A N   1 
ATOM   3218 C  CA  . SER A 1 481 ? 104.911 106.334 100.326 1.00 46.18  ? 481 SER A CA  1 
ATOM   3219 C  C   . SER A 1 481 ? 106.252 105.704 100.681 1.00 48.40  ? 481 SER A C   1 
ATOM   3220 O  O   . SER A 1 481 ? 107.015 105.323 99.786  1.00 61.17  ? 481 SER A O   1 
ATOM   3221 C  CB  . SER A 1 481 ? 105.067 107.844 100.141 1.00 56.49  ? 481 SER A CB  1 
ATOM   3222 O  OG  . SER A 1 481 ? 103.811 108.493 100.221 1.00 56.56  ? 481 SER A OG  1 
ATOM   3223 N  N   . LEU A 1 482 ? 106.542 105.579 101.979 1.00 36.03  ? 482 LEU A N   1 
ATOM   3224 C  CA  . LEU A 1 482 ? 107.777 104.933 102.411 1.00 35.88  ? 482 LEU A CA  1 
ATOM   3225 C  C   . LEU A 1 482 ? 107.829 103.483 101.950 1.00 40.54  ? 482 LEU A C   1 
ATOM   3226 O  O   . LEU A 1 482 ? 108.862 103.017 101.452 1.00 52.81  ? 482 LEU A O   1 
ATOM   3227 C  CB  . LEU A 1 482 ? 107.900 105.003 103.934 1.00 47.29  ? 482 LEU A CB  1 
ATOM   3228 C  CG  . LEU A 1 482 ? 107.750 106.359 104.624 1.00 44.31  ? 482 LEU A CG  1 
ATOM   3229 C  CD1 . LEU A 1 482 ? 107.092 106.188 105.978 1.00 40.25  ? 482 LEU A CD1 1 
ATOM   3230 C  CD2 . LEU A 1 482 ? 109.101 107.022 104.781 1.00 43.24  ? 482 LEU A CD2 1 
ATOM   3231 N  N   . VAL A 1 483 ? 106.721 102.758 102.106 1.00 36.98  ? 483 VAL A N   1 
ATOM   3232 C  CA  . VAL A 1 483 ? 106.679 101.350 101.723 1.00 44.44  ? 483 VAL A CA  1 
ATOM   3233 C  C   . VAL A 1 483 ? 106.858 101.202 100.218 1.00 49.25  ? 483 VAL A C   1 
ATOM   3234 O  O   . VAL A 1 483 ? 107.595 100.326 99.748  1.00 55.70  ? 483 VAL A O   1 
ATOM   3235 C  CB  . VAL A 1 483 ? 105.364 100.712 102.206 1.00 40.13  ? 483 VAL A CB  1 
ATOM   3236 C  CG1 . VAL A 1 483 ? 105.455 99.201  102.153 1.00 48.29  ? 483 VAL A CG1 1 
ATOM   3237 C  CG2 . VAL A 1 483 ? 105.036 101.182 103.612 1.00 40.93  ? 483 VAL A CG2 1 
ATOM   3238 N  N   . VAL A 1 484 ? 106.192 102.058 99.441  1.00 40.05  ? 484 VAL A N   1 
ATOM   3239 C  CA  . VAL A 1 484 ? 106.304 102.004 97.986  1.00 41.21  ? 484 VAL A CA  1 
ATOM   3240 C  C   . VAL A 1 484 ? 107.735 102.288 97.545  1.00 47.18  ? 484 VAL A C   1 
ATOM   3241 O  O   . VAL A 1 484 ? 108.285 101.588 96.685  1.00 54.29  ? 484 VAL A O   1 
ATOM   3242 C  CB  . VAL A 1 484 ? 105.305 102.985 97.344  1.00 43.89  ? 484 VAL A CB  1 
ATOM   3243 C  CG1 . VAL A 1 484 ? 105.498 103.044 95.841  1.00 48.64  ? 484 VAL A CG1 1 
ATOM   3244 C  CG2 . VAL A 1 484 ? 103.881 102.587 97.688  1.00 41.69  ? 484 VAL A CG2 1 
ATOM   3245 N  N   . ILE A 1 485 ? 108.361 103.315 98.126  1.00 35.89  ? 485 ILE A N   1 
ATOM   3246 C  CA  . ILE A 1 485 ? 109.730 103.658 97.750  1.00 39.46  ? 485 ILE A CA  1 
ATOM   3247 C  C   . ILE A 1 485 ? 110.688 102.525 98.105  1.00 43.45  ? 485 ILE A C   1 
ATOM   3248 O  O   . ILE A 1 485 ? 111.561 102.156 97.307  1.00 53.75  ? 485 ILE A O   1 
ATOM   3249 C  CB  . ILE A 1 485 ? 110.144 104.987 98.409  1.00 41.03  ? 485 ILE A CB  1 
ATOM   3250 C  CG1 . ILE A 1 485 ? 109.363 106.149 97.794  1.00 39.37  ? 485 ILE A CG1 1 
ATOM   3251 C  CG2 . ILE A 1 485 ? 111.636 105.221 98.263  1.00 46.63  ? 485 ILE A CG2 1 
ATOM   3252 C  CD1 . ILE A 1 485 ? 109.529 107.453 98.533  1.00 41.61  ? 485 ILE A CD1 1 
ATOM   3253 N  N   . SER A 1 486 ? 110.537 101.951 99.302  1.00 40.81  ? 486 SER A N   1 
ATOM   3254 C  CA  . SER A 1 486 ? 111.413 100.858 99.712  1.00 44.28  ? 486 SER A CA  1 
ATOM   3255 C  C   . SER A 1 486 ? 111.244 99.641  98.811  1.00 49.21  ? 486 SER A C   1 
ATOM   3256 O  O   . SER A 1 486 ? 112.232 98.997  98.432  1.00 53.13  ? 486 SER A O   1 
ATOM   3257 C  CB  . SER A 1 486 ? 111.139 100.490 101.169 1.00 41.11  ? 486 SER A CB  1 
ATOM   3258 O  OG  . SER A 1 486 ? 111.977 101.220 102.044 1.00 51.69  ? 486 SER A OG  1 
ATOM   3259 N  N   . CYS A 1 487 ? 110.001 99.308  98.458  1.00 46.15  ? 487 CYS A N   1 
ATOM   3260 C  CA  . CYS A 1 487 ? 109.764 98.171  97.577  1.00 42.56  ? 487 CYS A CA  1 
ATOM   3261 C  C   . CYS A 1 487 ? 110.351 98.411  96.192  1.00 49.11  ? 487 CYS A C   1 
ATOM   3262 O  O   . CYS A 1 487 ? 110.925 97.497  95.589  1.00 49.04  ? 487 CYS A O   1 
ATOM   3263 C  CB  . CYS A 1 487 ? 108.268 97.880  97.487  1.00 46.92  ? 487 CYS A CB  1 
ATOM   3264 S  SG  . CYS A 1 487 ? 107.859 96.247  96.836  1.00 75.41  ? 487 CYS A SG  1 
ATOM   3265 N  N   . ILE A 1 488 ? 110.216 99.632  95.668  1.00 44.93  ? 488 ILE A N   1 
ATOM   3266 C  CA  . ILE A 1 488 ? 110.788 99.938  94.358  1.00 44.13  ? 488 ILE A CA  1 
ATOM   3267 C  C   . ILE A 1 488 ? 112.305 99.808  94.394  1.00 46.67  ? 488 ILE A C   1 
ATOM   3268 O  O   . ILE A 1 488 ? 112.917 99.263  93.468  1.00 55.37  ? 488 ILE A O   1 
ATOM   3269 C  CB  . ILE A 1 488 ? 110.346 101.336 93.887  1.00 44.42  ? 488 ILE A CB  1 
ATOM   3270 C  CG1 . ILE A 1 488 ? 108.896 101.298 93.407  1.00 43.14  ? 488 ILE A CG1 1 
ATOM   3271 C  CG2 . ILE A 1 488 ? 111.246 101.839 92.771  1.00 45.03  ? 488 ILE A CG2 1 
ATOM   3272 C  CD1 . ILE A 1 488 ? 108.239 102.654 93.336  1.00 46.36  ? 488 ILE A CD1 1 
ATOM   3273 N  N   . MET A 1 489 ? 112.938 100.302 95.462  1.00 39.62  ? 489 MET A N   1 
ATOM   3274 C  CA  . MET A 1 489 ? 114.389 100.174 95.576  1.00 43.36  ? 489 MET A CA  1 
ATOM   3275 C  C   . MET A 1 489 ? 114.814 98.709  95.650  1.00 47.65  ? 489 MET A C   1 
ATOM   3276 O  O   . MET A 1 489 ? 115.782 98.298  94.993  1.00 52.33  ? 489 MET A O   1 
ATOM   3277 C  CB  . MET A 1 489 ? 114.889 100.948 96.795  1.00 43.25  ? 489 MET A CB  1 
ATOM   3278 C  CG  . MET A 1 489 ? 116.130 100.366 97.449  1.00 49.24  ? 489 MET A CG  1 
ATOM   3279 S  SD  . MET A 1 489 ? 116.568 101.216 98.977  1.00 71.11  ? 489 MET A SD  1 
ATOM   3280 C  CE  . MET A 1 489 ? 116.458 99.876  100.158 1.00 53.18  ? 489 MET A CE  1 
ATOM   3281 N  N   . CYS A 1 490 ? 114.092 97.903  96.434  1.00 42.83  ? 490 CYS A N   1 
ATOM   3282 C  CA  . CYS A 1 490 ? 114.422 96.484  96.539  1.00 44.33  ? 490 CYS A CA  1 
ATOM   3283 C  C   . CYS A 1 490 ? 114.279 95.779  95.196  1.00 47.43  ? 490 CYS A C   1 
ATOM   3284 O  O   . CYS A 1 490 ? 115.133 94.967  94.819  1.00 48.10  ? 490 CYS A O   1 
ATOM   3285 C  CB  . CYS A 1 490 ? 113.535 95.816  97.589  1.00 47.97  ? 490 CYS A CB  1 
ATOM   3286 S  SG  . CYS A 1 490 ? 113.844 94.052  97.819  1.00 52.86  ? 490 CYS A SG  1 
ATOM   3287 N  N   . VAL A 1 491 ? 113.206 96.075  94.460  1.00 47.62  ? 491 VAL A N   1 
ATOM   3288 C  CA  . VAL A 1 491 ? 112.997 95.451  93.156  1.00 46.88  ? 491 VAL A CA  1 
ATOM   3289 C  C   . VAL A 1 491 ? 114.087 95.871  92.180  1.00 48.31  ? 491 VAL A C   1 
ATOM   3290 O  O   . VAL A 1 491 ? 114.606 95.050  91.414  1.00 46.00  ? 491 VAL A O   1 
ATOM   3291 C  CB  . VAL A 1 491 ? 111.594 95.792  92.621  1.00 49.84  ? 491 VAL A CB  1 
ATOM   3292 C  CG1 . VAL A 1 491 ? 111.441 95.325  91.184  1.00 49.03  ? 491 VAL A CG1 1 
ATOM   3293 C  CG2 . VAL A 1 491 ? 110.542 95.161  93.498  1.00 44.80  ? 491 VAL A CG2 1 
ATOM   3294 N  N   . ALA A 1 492 ? 114.451 97.156  92.190  1.00 51.65  ? 492 ALA A N   1 
ATOM   3295 C  CA  . ALA A 1 492 ? 115.501 97.633  91.298  1.00 46.77  ? 492 ALA A CA  1 
ATOM   3296 C  C   . ALA A 1 492 ? 116.826 96.941  91.585  1.00 48.17  ? 492 ALA A C   1 
ATOM   3297 O  O   . ALA A 1 492 ? 117.562 96.585  90.658  1.00 41.59  ? 492 ALA A O   1 
ATOM   3298 C  CB  . ALA A 1 492 ? 115.648 99.148  91.424  1.00 40.72  ? 492 ALA A CB  1 
ATOM   3299 N  N   . ILE A 1 493 ? 117.151 96.741  92.864  1.00 50.77  ? 493 ILE A N   1 
ATOM   3300 C  CA  . ILE A 1 493 ? 118.408 96.078  93.199  1.00 42.33  ? 493 ILE A CA  1 
ATOM   3301 C  C   . ILE A 1 493 ? 118.364 94.599  92.824  1.00 47.40  ? 493 ILE A C   1 
ATOM   3302 O  O   . ILE A 1 493 ? 119.330 94.058  92.273  1.00 42.97  ? 493 ILE A O   1 
ATOM   3303 C  CB  . ILE A 1 493 ? 118.738 96.277  94.690  1.00 44.84  ? 493 ILE A CB  1 
ATOM   3304 C  CG1 . ILE A 1 493 ? 119.082 97.741  94.968  1.00 43.92  ? 493 ILE A CG1 1 
ATOM   3305 C  CG2 . ILE A 1 493 ? 119.887 95.376  95.107  1.00 46.46  ? 493 ILE A CG2 1 
ATOM   3306 C  CD1 . ILE A 1 493 ? 119.627 97.987  96.355  1.00 36.59  ? 493 ILE A CD1 1 
ATOM   3307 N  N   . MET A 1 494 ? 117.249 93.921  93.104  1.00 50.47  ? 494 MET A N   1 
ATOM   3308 C  CA  . MET A 1 494 ? 117.174 92.475  92.923  1.00 41.89  ? 494 MET A CA  1 
ATOM   3309 C  C   . MET A 1 494 ? 116.992 92.030  91.477  1.00 43.29  ? 494 MET A C   1 
ATOM   3310 O  O   . MET A 1 494 ? 117.551 90.999  91.088  1.00 53.36  ? 494 MET A O   1 
ATOM   3311 C  CB  . MET A 1 494 ? 116.036 91.897  93.770  1.00 35.83  ? 494 MET A CB  1 
ATOM   3312 C  CG  . MET A 1 494 ? 116.440 91.526  95.186  1.00 43.22  ? 494 MET A CG  1 
ATOM   3313 S  SD  . MET A 1 494 ? 118.117 90.871  95.246  1.00 64.13  ? 494 MET A SD  1 
ATOM   3314 C  CE  . MET A 1 494 ? 118.764 91.672  96.703  1.00 49.13  ? 494 MET A CE  1 
ATOM   3315 N  N   . TYR A 1 495 ? 116.229 92.763  90.665  1.00 52.51  ? 495 TYR A N   1 
ATOM   3316 C  CA  . TYR A 1 495 ? 115.846 92.270  89.349  1.00 44.63  ? 495 TYR A CA  1 
ATOM   3317 C  C   . TYR A 1 495 ? 116.430 93.048  88.181  1.00 43.79  ? 495 TYR A C   1 
ATOM   3318 O  O   . TYR A 1 495 ? 116.377 92.550  87.052  1.00 49.27  ? 495 TYR A O   1 
ATOM   3319 C  CB  . TYR A 1 495 ? 114.316 92.248  89.212  1.00 44.75  ? 495 TYR A CB  1 
ATOM   3320 C  CG  . TYR A 1 495 ? 113.665 91.153  90.024  1.00 45.92  ? 495 TYR A CG  1 
ATOM   3321 C  CD1 . TYR A 1 495 ? 113.594 89.854  89.542  1.00 47.58  ? 495 TYR A CD1 1 
ATOM   3322 C  CD2 . TYR A 1 495 ? 113.137 91.414  91.280  1.00 49.03  ? 495 TYR A CD2 1 
ATOM   3323 C  CE1 . TYR A 1 495 ? 113.008 88.850  90.285  1.00 50.67  ? 495 TYR A CE1 1 
ATOM   3324 C  CE2 . TYR A 1 495 ? 112.551 90.417  92.029  1.00 43.37  ? 495 TYR A CE2 1 
ATOM   3325 C  CZ  . TYR A 1 495 ? 112.489 89.138  91.527  1.00 49.29  ? 495 TYR A CZ  1 
ATOM   3326 O  OH  . TYR A 1 495 ? 111.904 88.141  92.271  1.00 54.44  ? 495 TYR A OH  1 
ATOM   3327 N  N   . ILE A 1 496 ? 116.981 94.239  88.404  1.00 46.37  ? 496 ILE A N   1 
ATOM   3328 C  CA  . ILE A 1 496 ? 117.604 94.997  87.324  1.00 49.38  ? 496 ILE A CA  1 
ATOM   3329 C  C   . ILE A 1 496 ? 119.114 94.822  87.406  1.00 49.60  ? 496 ILE A C   1 
ATOM   3330 O  O   . ILE A 1 496 ? 119.780 94.591  86.391  1.00 51.76  ? 496 ILE A O   1 
ATOM   3331 C  CB  . ILE A 1 496 ? 117.203 96.483  87.378  1.00 46.28  ? 496 ILE A CB  1 
ATOM   3332 C  CG1 . ILE A 1 496 ? 115.816 96.678  86.764  1.00 43.95  ? 496 ILE A CG1 1 
ATOM   3333 C  CG2 . ILE A 1 496 ? 118.218 97.342  86.648  1.00 42.28  ? 496 ILE A CG2 1 
ATOM   3334 C  CD1 . ILE A 1 496 ? 114.936 97.622  87.538  1.00 48.16  ? 496 ILE A CD1 1 
ATOM   3335 N  N   . TYR A 1 497 ? 119.661 94.918  88.616  1.00 44.55  ? 497 TYR A N   1 
ATOM   3336 C  CA  . TYR A 1 497 ? 121.092 94.745  88.827  1.00 42.75  ? 497 TYR A CA  1 
ATOM   3337 C  C   . TYR A 1 497 ? 121.492 93.276  88.908  1.00 48.77  ? 497 TYR A C   1 
ATOM   3338 O  O   . TYR A 1 497 ? 122.552 92.896  88.400  1.00 48.23  ? 497 TYR A O   1 
ATOM   3339 C  CB  . TYR A 1 497 ? 121.524 95.480  90.099  1.00 36.20  ? 497 TYR A CB  1 
ATOM   3340 C  CG  . TYR A 1 497 ? 122.981 95.304  90.458  1.00 44.02  ? 497 TYR A CG  1 
ATOM   3341 C  CD1 . TYR A 1 497 ? 123.983 95.783  89.627  1.00 36.77  ? 497 TYR A CD1 1 
ATOM   3342 C  CD2 . TYR A 1 497 ? 123.354 94.674  91.637  1.00 46.51  ? 497 TYR A CD2 1 
ATOM   3343 C  CE1 . TYR A 1 497 ? 125.314 95.629  89.954  1.00 40.08  ? 497 TYR A CE1 1 
ATOM   3344 C  CE2 . TYR A 1 497 ? 124.683 94.519  91.972  1.00 47.31  ? 497 TYR A CE2 1 
ATOM   3345 C  CZ  . TYR A 1 497 ? 125.658 94.997  91.126  1.00 44.89  ? 497 TYR A CZ  1 
ATOM   3346 O  OH  . TYR A 1 497 ? 126.983 94.843  91.456  1.00 49.11  ? 497 TYR A OH  1 
ATOM   3347 N  N   . GLY A 1 498 ? 120.663 92.443  89.529  1.00 43.61  ? 498 GLY A N   1 
ATOM   3348 C  CA  . GLY A 1 498 ? 120.950 91.014  89.659  1.00 39.63  ? 498 GLY A CA  1 
ATOM   3349 C  C   . GLY A 1 498 ? 121.195 90.654  91.111  1.00 48.68  ? 498 GLY A C   1 
ATOM   3350 O  O   . GLY A 1 498 ? 121.987 91.282  91.811  1.00 63.03  ? 498 GLY A O   1 
ATOM   3351 N  N   . HIS A 1 499 ? 120.493 89.616  91.572  1.00 51.16  ? 499 HIS A N   1 
ATOM   3352 C  CA  . HIS A 1 499 ? 120.632 89.197  92.964  1.00 40.64  ? 499 HIS A CA  1 
ATOM   3353 C  C   . HIS A 1 499 ? 121.982 88.537  93.218  1.00 46.72  ? 499 HIS A C   1 
ATOM   3354 O  O   . HIS A 1 499 ? 122.548 88.675  94.307  1.00 61.21  ? 499 HIS A O   1 
ATOM   3355 C  CB  . HIS A 1 499 ? 119.485 88.263  93.354  1.00 42.37  ? 499 HIS A CB  1 
ATOM   3356 C  CG  . HIS A 1 499 ? 119.388 87.027  92.515  1.00 54.56  ? 499 HIS A CG  1 
ATOM   3357 N  ND1 . HIS A 1 499 ? 119.924 85.819  92.904  1.00 57.60  ? 499 HIS A ND1 1 
ATOM   3358 C  CD2 . HIS A 1 499 ? 118.802 86.809  91.314  1.00 57.48  ? 499 HIS A CD2 1 
ATOM   3359 C  CE1 . HIS A 1 499 ? 119.681 84.912  91.975  1.00 54.18  ? 499 HIS A CE1 1 
ATOM   3360 N  NE2 . HIS A 1 499 ? 119.002 85.487  91.000  1.00 56.50  ? 499 HIS A NE2 1 
ATOM   3361 N  N   . ARG A 1 500 ? 122.513 87.814  92.228  1.00 40.34  ? 500 ARG A N   1 
ATOM   3362 C  CA  . ARG A 1 500 ? 123.808 87.162  92.396  1.00 48.69  ? 500 ARG A CA  1 
ATOM   3363 C  C   . ARG A 1 500 ? 124.927 88.174  92.607  1.00 57.04  ? 500 ARG A C   1 
ATOM   3364 O  O   . ARG A 1 500 ? 125.798 87.972  93.465  1.00 66.31  ? 500 ARG A O   1 
ATOM   3365 C  CB  . ARG A 1 500 ? 124.107 86.286  91.182  1.00 52.22  ? 500 ARG A CB  1 
ATOM   3366 C  CG  . ARG A 1 500 ? 123.422 84.933  91.211  1.00 56.98  ? 500 ARG A CG  1 
ATOM   3367 C  CD  . ARG A 1 500 ? 123.969 84.017  90.132  1.00 59.64  ? 500 ARG A CD  1 
ATOM   3368 N  NE  . ARG A 1 500 ? 123.352 84.274  88.835  1.00 65.47  ? 500 ARG A NE  1 
ATOM   3369 C  CZ  . ARG A 1 500 ? 122.116 83.921  88.508  1.00 64.35  ? 500 ARG A CZ  1 
ATOM   3370 N  NH1 . ARG A 1 500 ? 121.336 83.266  89.352  1.00 61.47  ? 500 ARG A NH1 1 
ATOM   3371 N  NH2 . ARG A 1 500 ? 121.652 84.230  87.301  1.00 61.34  ? 500 ARG A NH2 1 
ATOM   3372 N  N   . ASN A 1 501 ? 124.922 89.265  91.839  1.00 44.63  ? 501 ASN A N   1 
ATOM   3373 C  CA  . ASN A 1 501 ? 125.937 90.298  91.996  1.00 38.39  ? 501 ASN A CA  1 
ATOM   3374 C  C   . ASN A 1 501 ? 125.875 90.926  93.383  1.00 47.29  ? 501 ASN A C   1 
ATOM   3375 O  O   . ASN A 1 501 ? 126.911 91.145  94.019  1.00 57.92  ? 501 ASN A O   1 
ATOM   3376 C  CB  . ASN A 1 501 ? 125.771 91.367  90.915  1.00 49.93  ? 501 ASN A CB  1 
ATOM   3377 C  CG  . ASN A 1 501 ? 125.892 90.806  89.513  1.00 53.57  ? 501 ASN A CG  1 
ATOM   3378 O  OD1 . ASN A 1 501 ? 126.662 89.879  89.267  1.00 58.91  ? 501 ASN A OD1 1 
ATOM   3379 N  ND2 . ASN A 1 501 ? 125.131 91.369  88.584  1.00 49.72  ? 501 ASN A ND2 1 
ATOM   3380 N  N   . TYR A 1 502 ? 124.667 91.211  93.873  1.00 38.20  ? 502 TYR A N   1 
ATOM   3381 C  CA  . TYR A 1 502 ? 124.533 91.807  95.199  1.00 38.88  ? 502 TYR A CA  1 
ATOM   3382 C  C   . TYR A 1 502 ? 124.950 90.832  96.293  1.00 42.13  ? 502 TYR A C   1 
ATOM   3383 O  O   . TYR A 1 502 ? 125.539 91.237  97.301  1.00 50.13  ? 502 TYR A O   1 
ATOM   3384 C  CB  . TYR A 1 502 ? 123.100 92.284  95.419  1.00 41.12  ? 502 TYR A CB  1 
ATOM   3385 C  CG  . TYR A 1 502 ? 122.964 93.289  96.538  1.00 47.73  ? 502 TYR A CG  1 
ATOM   3386 C  CD1 . TYR A 1 502 ? 123.486 94.569  96.415  1.00 45.85  ? 502 TYR A CD1 1 
ATOM   3387 C  CD2 . TYR A 1 502 ? 122.317 92.958  97.719  1.00 47.35  ? 502 TYR A CD2 1 
ATOM   3388 C  CE1 . TYR A 1 502 ? 123.366 95.490  97.435  1.00 42.29  ? 502 TYR A CE1 1 
ATOM   3389 C  CE2 . TYR A 1 502 ? 122.191 93.872  98.744  1.00 43.96  ? 502 TYR A CE2 1 
ATOM   3390 C  CZ  . TYR A 1 502 ? 122.718 95.136  98.597  1.00 43.95  ? 502 TYR A CZ  1 
ATOM   3391 O  OH  . TYR A 1 502 ? 122.594 96.048  99.618  1.00 49.49  ? 502 TYR A OH  1 
ATOM   3392 N  N   . PHE A 1 503 ? 124.647 89.544  96.119  1.00 41.74  ? 503 PHE A N   1 
ATOM   3393 C  CA  . PHE A 1 503 ? 125.081 88.550  97.095  1.00 39.86  ? 503 PHE A CA  1 
ATOM   3394 C  C   . PHE A 1 503 ? 126.601 88.465  97.146  1.00 44.54  ? 503 PHE A C   1 
ATOM   3395 O  O   . PHE A 1 503 ? 127.193 88.376  98.231  1.00 57.48  ? 503 PHE A O   1 
ATOM   3396 C  CB  . PHE A 1 503 ? 124.473 87.187  96.765  1.00 42.25  ? 503 PHE A CB  1 
ATOM   3397 C  CG  . PHE A 1 503 ? 122.980 87.126  96.939  1.00 45.70  ? 503 PHE A CG  1 
ATOM   3398 C  CD1 . PHE A 1 503 ? 122.298 88.138  97.595  1.00 43.83  ? 503 PHE A CD1 1 
ATOM   3399 C  CD2 . PHE A 1 503 ? 122.257 86.059  96.438  1.00 43.74  ? 503 PHE A CD2 1 
ATOM   3400 C  CE1 . PHE A 1 503 ? 120.928 88.083  97.750  1.00 42.95  ? 503 PHE A CE1 1 
ATOM   3401 C  CE2 . PHE A 1 503 ? 120.886 86.000  96.590  1.00 40.20  ? 503 PHE A CE2 1 
ATOM   3402 C  CZ  . PHE A 1 503 ? 120.222 87.014  97.246  1.00 42.86  ? 503 PHE A CZ  1 
ATOM   3403 N  N   . GLN A 1 504 ? 127.253 88.503  95.982  1.00 43.53  ? 504 GLN A N   1 
ATOM   3404 C  CA  . GLN A 1 504 ? 128.713 88.520  95.960  1.00 45.14  ? 504 GLN A CA  1 
ATOM   3405 C  C   . GLN A 1 504 ? 129.262 89.793  96.598  1.00 50.41  ? 504 GLN A C   1 
ATOM   3406 O  O   . GLN A 1 504 ? 130.275 89.752  97.307  1.00 53.09  ? 504 GLN A O   1 
ATOM   3407 C  CB  . GLN A 1 504 ? 129.218 88.368  94.526  1.00 41.88  ? 504 GLN A CB  1 
ATOM   3408 C  CG  . GLN A 1 504 ? 129.099 86.953  93.986  1.00 48.20  ? 504 GLN A CG  1 
ATOM   3409 C  CD  . GLN A 1 504 ? 129.567 86.830  92.549  1.00 62.61  ? 504 GLN A CD  1 
ATOM   3410 O  OE1 . GLN A 1 504 ? 130.695 86.415  92.287  1.00 64.42  ? 504 GLN A OE1 1 
ATOM   3411 N  NE2 . GLN A 1 504 ? 128.699 87.189  91.611  1.00 58.31  ? 504 GLN A NE2 1 
ATOM   3412 N  N   . ASP A 1 505 ? 128.605 90.931  96.363  1.00 49.27  ? 505 ASP A N   1 
ATOM   3413 C  CA  . ASP A 1 505 ? 129.030 92.180  96.991  1.00 41.97  ? 505 ASP A CA  1 
ATOM   3414 C  C   . ASP A 1 505 ? 128.947 92.093  98.510  1.00 44.90  ? 505 ASP A C   1 
ATOM   3415 O  O   . ASP A 1 505 ? 129.844 92.564  99.216  1.00 52.34  ? 505 ASP A O   1 
ATOM   3416 C  CB  . ASP A 1 505 ? 128.176 93.341  96.483  1.00 39.96  ? 505 ASP A CB  1 
ATOM   3417 C  CG  . ASP A 1 505 ? 128.356 93.594  95.006  1.00 50.12  ? 505 ASP A CG  1 
ATOM   3418 O  OD1 . ASP A 1 505 ? 129.240 92.960  94.397  1.00 58.08  ? 505 ASP A OD1 1 
ATOM   3419 O  OD2 . ASP A 1 505 ? 127.610 94.425  94.450  1.00 45.80  ? 505 ASP A OD2 1 
ATOM   3420 N  N   . ILE A 1 506 ? 127.864 91.513  99.029  1.00 49.18  ? 506 ILE A N   1 
ATOM   3421 C  CA  . ILE A 1 506 ? 127.720 91.363  100.475 1.00 48.65  ? 506 ILE A CA  1 
ATOM   3422 C  C   . ILE A 1 506 ? 128.787 90.424  101.024 1.00 34.99  ? 506 ILE A C   1 
ATOM   3423 O  O   . ILE A 1 506 ? 129.388 90.688  102.074 1.00 45.02  ? 506 ILE A O   1 
ATOM   3424 C  CB  . ILE A 1 506 ? 126.300 90.881  100.826 1.00 44.93  ? 506 ILE A CB  1 
ATOM   3425 C  CG1 . ILE A 1 506 ? 125.326 92.059  100.821 1.00 41.91  ? 506 ILE A CG1 1 
ATOM   3426 C  CG2 . ILE A 1 506 ? 126.282 90.194  102.178 1.00 44.62  ? 506 ILE A CG2 1 
ATOM   3427 C  CD1 . ILE A 1 506 ? 123.896 91.663  101.082 1.00 50.92  ? 506 ILE A CD1 1 
ATOM   3428 N  N   . GLN A 1 507 ? 129.039 89.313  100.324 1.00 42.80  ? 507 GLN A N   1 
ATOM   3429 C  CA  . GLN A 1 507 ? 130.077 88.384  100.759 1.00 40.46  ? 507 GLN A CA  1 
ATOM   3430 C  C   . GLN A 1 507 ? 131.457 89.031  100.733 1.00 43.93  ? 507 GLN A C   1 
ATOM   3431 O  O   . GLN A 1 507 ? 132.340 88.638  101.503 1.00 49.32  ? 507 GLN A O   1 
ATOM   3432 C  CB  . GLN A 1 507 ? 130.057 87.133  99.882  1.00 43.73  ? 507 GLN A CB  1 
ATOM   3433 C  CG  . GLN A 1 507 ? 131.138 86.117  100.209 1.00 47.05  ? 507 GLN A CG  1 
ATOM   3434 C  CD  . GLN A 1 507 ? 130.800 84.728  99.718  1.00 59.14  ? 507 GLN A CD  1 
ATOM   3435 O  OE1 . GLN A 1 507 ? 129.965 84.558  98.830  1.00 66.45  ? 507 GLN A OE1 1 
ATOM   3436 N  NE2 . GLN A 1 507 ? 131.446 83.723  100.295 1.00 54.64  ? 507 GLN A NE2 1 
ATOM   3437 N  N   . MET A 1 508 ? 131.658 90.022  99.862  1.00 56.90  ? 508 MET A N   1 
ATOM   3438 C  CA  . MET A 1 508 ? 132.944 90.714  99.812  1.00 51.82  ? 508 MET A CA  1 
ATOM   3439 C  C   . MET A 1 508 ? 133.280 91.362  101.149 1.00 50.37  ? 508 MET A C   1 
ATOM   3440 O  O   . MET A 1 508 ? 134.427 91.296  101.607 1.00 56.67  ? 508 MET A O   1 
ATOM   3441 C  CB  . MET A 1 508 ? 132.933 91.766  98.702  1.00 46.35  ? 508 MET A CB  1 
ATOM   3442 C  CG  . MET A 1 508 ? 133.450 91.270  97.365  1.00 53.28  ? 508 MET A CG  1 
ATOM   3443 S  SD  . MET A 1 508 ? 133.484 92.567  96.117  1.00 66.99  ? 508 MET A SD  1 
ATOM   3444 C  CE  . MET A 1 508 ? 134.955 93.459  96.602  1.00 48.03  ? 508 MET A CE  1 
ATOM   3445 N  N   . MET A 1 509 ? 132.297 91.995  101.790 1.00 43.45  ? 509 MET A N   1 
ATOM   3446 C  CA  . MET A 1 509 ? 132.527 92.658  103.068 1.00 32.71  ? 509 MET A CA  1 
ATOM   3447 C  C   . MET A 1 509 ? 132.363 91.723  104.259 1.00 43.28  ? 509 MET A C   1 
ATOM   3448 O  O   . MET A 1 509 ? 133.239 91.674  105.128 1.00 55.62  ? 509 MET A O   1 
ATOM   3449 C  CB  . MET A 1 509 ? 131.576 93.845  103.233 1.00 30.40  ? 509 MET A CB  1 
ATOM   3450 C  CG  . MET A 1 509 ? 131.013 94.395  101.945 1.00 46.94  ? 509 MET A CG  1 
ATOM   3451 S  SD  . MET A 1 509 ? 130.058 95.894  102.232 1.00 58.21  ? 509 MET A SD  1 
ATOM   3452 C  CE  . MET A 1 509 ? 128.530 95.201  102.850 1.00 47.52  ? 509 MET A CE  1 
ATOM   3453 N  N   . LEU A 1 510 ? 131.256 90.980  104.324 1.00 51.96  ? 510 LEU A N   1 
ATOM   3454 C  CA  . LEU A 1 510 ? 130.970 90.196  105.520 1.00 37.90  ? 510 LEU A CA  1 
ATOM   3455 C  C   . LEU A 1 510 ? 131.834 88.947  105.624 1.00 45.08  ? 510 LEU A C   1 
ATOM   3456 O  O   . LEU A 1 510 ? 132.125 88.493  106.735 1.00 52.54  ? 510 LEU A O   1 
ATOM   3457 C  CB  . LEU A 1 510 ? 129.491 89.811  105.556 1.00 34.83  ? 510 LEU A CB  1 
ATOM   3458 C  CG  . LEU A 1 510 ? 128.509 90.950  105.834 1.00 46.42  ? 510 LEU A CG  1 
ATOM   3459 C  CD1 . LEU A 1 510 ? 127.149 90.400  106.223 1.00 50.02  ? 510 LEU A CD1 1 
ATOM   3460 C  CD2 . LEU A 1 510 ? 129.045 91.874  106.912 1.00 41.54  ? 510 LEU A CD2 1 
ATOM   3461 N  N   . GLY A 1 511 ? 132.254 88.381  104.496 1.00 49.44  ? 511 GLY A N   1 
ATOM   3462 C  CA  . GLY A 1 511 ? 133.013 87.151  104.491 1.00 48.51  ? 511 GLY A CA  1 
ATOM   3463 C  C   . GLY A 1 511 ? 132.182 85.890  104.417 1.00 58.80  ? 511 GLY A C   1 
ATOM   3464 O  O   . GLY A 1 511 ? 132.747 84.805  104.233 1.00 59.59  ? 511 GLY A O   1 
ATOM   3465 N  N   . PHE A 1 512 ? 130.864 85.995  104.557 1.00 60.06  ? 512 PHE A N   1 
ATOM   3466 C  CA  . PHE A 1 512 ? 129.945 84.883  104.388 1.00 49.84  ? 512 PHE A CA  1 
ATOM   3467 C  C   . PHE A 1 512 ? 128.736 85.371  103.606 1.00 54.47  ? 512 PHE A C   1 
ATOM   3468 O  O   . PHE A 1 512 ? 128.395 86.558  103.669 1.00 57.01  ? 512 PHE A O   1 
ATOM   3469 C  CB  . PHE A 1 512 ? 129.504 84.294  105.740 1.00 50.02  ? 512 PHE A CB  1 
ATOM   3470 C  CG  . PHE A 1 512 ? 129.076 85.324  106.751 1.00 52.58  ? 512 PHE A CG  1 
ATOM   3471 C  CD1 . PHE A 1 512 ? 127.818 85.901  106.689 1.00 54.11  ? 512 PHE A CD1 1 
ATOM   3472 C  CD2 . PHE A 1 512 ? 129.928 85.705  107.772 1.00 53.51  ? 512 PHE A CD2 1 
ATOM   3473 C  CE1 . PHE A 1 512 ? 127.425 86.842  107.618 1.00 49.45  ? 512 PHE A CE1 1 
ATOM   3474 C  CE2 . PHE A 1 512 ? 129.540 86.646  108.704 1.00 56.96  ? 512 PHE A CE2 1 
ATOM   3475 C  CZ  . PHE A 1 512 ? 128.287 87.215  108.627 1.00 54.80  ? 512 PHE A CZ  1 
ATOM   3476 N  N   . PRO A 1 513 ? 128.080 84.492  102.853 1.00 55.97  ? 513 PRO A N   1 
ATOM   3477 C  CA  . PRO A 1 513 ? 126.893 84.905  102.098 1.00 51.03  ? 513 PRO A CA  1 
ATOM   3478 C  C   . PRO A 1 513 ? 125.746 85.228  103.036 1.00 58.85  ? 513 PRO A C   1 
ATOM   3479 O  O   . PRO A 1 513 ? 125.683 84.699  104.156 1.00 61.89  ? 513 PRO A O   1 
ATOM   3480 C  CB  . PRO A 1 513 ? 126.573 83.678  101.227 1.00 47.77  ? 513 PRO A CB  1 
ATOM   3481 C  CG  . PRO A 1 513 ? 127.749 82.764  101.356 1.00 53.35  ? 513 PRO A CG  1 
ATOM   3482 C  CD  . PRO A 1 513 ? 128.375 83.062  102.672 1.00 53.89  ? 513 PRO A CD  1 
ATOM   3483 N  N   . PRO A 1 514 ? 124.828 86.099  102.627 1.00 51.28  ? 514 PRO A N   1 
ATOM   3484 C  CA  . PRO A 1 514 ? 123.662 86.402  103.464 1.00 52.66  ? 514 PRO A CA  1 
ATOM   3485 C  C   . PRO A 1 514 ? 122.832 85.154  103.701 1.00 59.96  ? 514 PRO A C   1 
ATOM   3486 O  O   . PRO A 1 514 ? 122.742 84.283  102.823 1.00 59.09  ? 514 PRO A O   1 
ATOM   3487 C  CB  . PRO A 1 514 ? 122.885 87.444  102.644 1.00 45.94  ? 514 PRO A CB  1 
ATOM   3488 C  CG  . PRO A 1 514 ? 123.459 87.397  101.275 1.00 52.54  ? 514 PRO A CG  1 
ATOM   3489 C  CD  . PRO A 1 514 ? 124.854 86.890  101.386 1.00 46.35  ? 514 PRO A CD  1 
ATOM   3490 N  N   . PRO A 1 515 ? 122.223 85.023  104.879 1.00 51.67  ? 515 PRO A N   1 
ATOM   3491 C  CA  . PRO A 1 515 ? 121.435 83.820  105.170 1.00 51.06  ? 515 PRO A CA  1 
ATOM   3492 C  C   . PRO A 1 515 ? 120.233 83.693  104.245 1.00 55.83  ? 515 PRO A C   1 
ATOM   3493 O  O   . PRO A 1 515 ? 119.731 84.678  103.700 1.00 61.77  ? 515 PRO A O   1 
ATOM   3494 C  CB  . PRO A 1 515 ? 121.004 84.019  106.629 1.00 52.40  ? 515 PRO A CB  1 
ATOM   3495 C  CG  . PRO A 1 515 ? 121.186 85.475  106.896 1.00 55.26  ? 515 PRO A CG  1 
ATOM   3496 C  CD  . PRO A 1 515 ? 122.328 85.912  106.045 1.00 45.96  ? 515 PRO A CD  1 
ATOM   3497 N  N   . LEU A 1 516 ? 119.782 82.447  104.068 1.00 45.44  ? 516 LEU A N   1 
ATOM   3498 C  CA  . LEU A 1 516 ? 118.743 82.149  103.085 1.00 44.47  ? 516 LEU A CA  1 
ATOM   3499 C  C   . LEU A 1 516 ? 117.438 82.876  103.386 1.00 44.13  ? 516 LEU A C   1 
ATOM   3500 O  O   . LEU A 1 516 ? 116.673 83.181  102.462 1.00 49.89  ? 516 LEU A O   1 
ATOM   3501 C  CB  . LEU A 1 516 ? 118.506 80.641  103.024 1.00 43.31  ? 516 LEU A CB  1 
ATOM   3502 C  CG  . LEU A 1 516 ? 117.966 80.083  101.707 1.00 50.37  ? 516 LEU A CG  1 
ATOM   3503 C  CD1 . LEU A 1 516 ? 119.058 80.055  100.653 1.00 55.15  ? 516 LEU A CD1 1 
ATOM   3504 C  CD2 . LEU A 1 516 ? 117.384 78.698  101.916 1.00 48.79  ? 516 LEU A CD2 1 
ATOM   3505 N  N   . PHE A 1 517 ? 117.163 83.156  104.661 1.00 41.54  ? 517 PHE A N   1 
ATOM   3506 C  CA  . PHE A 1 517 ? 115.935 83.858  105.021 1.00 43.87  ? 517 PHE A CA  1 
ATOM   3507 C  C   . PHE A 1 517 ? 115.881 85.234  104.366 1.00 47.36  ? 517 PHE A C   1 
ATOM   3508 O  O   . PHE A 1 517 ? 114.865 85.613  103.769 1.00 55.33  ? 517 PHE A O   1 
ATOM   3509 C  CB  . PHE A 1 517 ? 115.835 83.974  106.542 1.00 38.16  ? 517 PHE A CB  1 
ATOM   3510 C  CG  . PHE A 1 517 ? 114.616 84.709  107.020 1.00 46.53  ? 517 PHE A CG  1 
ATOM   3511 C  CD1 . PHE A 1 517 ? 113.371 84.107  106.988 1.00 48.37  ? 517 PHE A CD1 1 
ATOM   3512 C  CD2 . PHE A 1 517 ? 114.717 86.000  107.508 1.00 45.52  ? 517 PHE A CD2 1 
ATOM   3513 C  CE1 . PHE A 1 517 ? 112.250 84.782  107.429 1.00 49.08  ? 517 PHE A CE1 1 
ATOM   3514 C  CE2 . PHE A 1 517 ? 113.601 86.679  107.950 1.00 42.25  ? 517 PHE A CE2 1 
ATOM   3515 C  CZ  . PHE A 1 517 ? 112.367 86.069  107.911 1.00 44.40  ? 517 PHE A CZ  1 
ATOM   3516 N  N   . PHE A 1 518 ? 116.979 85.987  104.449 1.00 44.06  ? 518 PHE A N   1 
ATOM   3517 C  CA  . PHE A 1 518 ? 117.013 87.315  103.847 1.00 45.15  ? 518 PHE A CA  1 
ATOM   3518 C  C   . PHE A 1 518 ? 116.954 87.240  102.328 1.00 47.49  ? 518 PHE A C   1 
ATOM   3519 O  O   . PHE A 1 518 ? 116.329 88.089  101.688 1.00 55.41  ? 518 PHE A O   1 
ATOM   3520 C  CB  . PHE A 1 518 ? 118.259 88.069  104.306 1.00 49.51  ? 518 PHE A CB  1 
ATOM   3521 C  CG  . PHE A 1 518 ? 118.166 88.584  105.712 1.00 53.06  ? 518 PHE A CG  1 
ATOM   3522 C  CD1 . PHE A 1 518 ? 117.578 89.807  105.977 1.00 49.27  ? 518 PHE A CD1 1 
ATOM   3523 C  CD2 . PHE A 1 518 ? 118.656 87.840  106.770 1.00 49.07  ? 518 PHE A CD2 1 
ATOM   3524 C  CE1 . PHE A 1 518 ? 117.487 90.280  107.269 1.00 49.80  ? 518 PHE A CE1 1 
ATOM   3525 C  CE2 . PHE A 1 518 ? 118.568 88.309  108.063 1.00 51.93  ? 518 PHE A CE2 1 
ATOM   3526 C  CZ  . PHE A 1 518 ? 117.982 89.531  108.313 1.00 49.45  ? 518 PHE A CZ  1 
ATOM   3527 N  N   . GLN A 1 519 ? 117.596 86.233  101.732 1.00 44.46  ? 519 GLN A N   1 
ATOM   3528 C  CA  . GLN A 1 519 ? 117.527 86.072  100.282 1.00 40.12  ? 519 GLN A CA  1 
ATOM   3529 C  C   . GLN A 1 519 ? 116.094 85.835  99.819  1.00 41.23  ? 519 GLN A C   1 
ATOM   3530 O  O   . GLN A 1 519 ? 115.619 86.484  98.876  1.00 51.14  ? 519 GLN A O   1 
ATOM   3531 C  CB  . GLN A 1 519 ? 118.428 84.918  99.844  1.00 35.51  ? 519 GLN A CB  1 
ATOM   3532 C  CG  . GLN A 1 519 ? 119.867 85.047  100.306 1.00 37.69  ? 519 GLN A CG  1 
ATOM   3533 C  CD  . GLN A 1 519 ? 120.755 83.954  99.753  1.00 44.78  ? 519 GLN A CD  1 
ATOM   3534 O  OE1 . GLN A 1 519 ? 120.330 83.154  98.923  1.00 52.14  ? 519 GLN A OE1 1 
ATOM   3535 N  NE2 . GLN A 1 519 ? 121.999 83.914  100.213 1.00 40.78  ? 519 GLN A NE2 1 
ATOM   3536 N  N   . ILE A 1 520 ? 115.385 84.916  100.479 1.00 47.69  ? 520 ILE A N   1 
ATOM   3537 C  CA  . ILE A 1 520 ? 114.010 84.623  100.087 1.00 42.96  ? 520 ILE A CA  1 
ATOM   3538 C  C   . ILE A 1 520 ? 113.102 85.817  100.350 1.00 36.82  ? 520 ILE A C   1 
ATOM   3539 O  O   . ILE A 1 520 ? 112.200 86.103  99.554  1.00 44.51  ? 520 ILE A O   1 
ATOM   3540 C  CB  . ILE A 1 520 ? 113.507 83.355  100.802 1.00 40.83  ? 520 ILE A CB  1 
ATOM   3541 C  CG1 . ILE A 1 520 ? 114.327 82.141  100.367 1.00 38.83  ? 520 ILE A CG1 1 
ATOM   3542 C  CG2 . ILE A 1 520 ? 112.038 83.116  100.507 1.00 45.74  ? 520 ILE A CG2 1 
ATOM   3543 C  CD1 . ILE A 1 520 ? 114.046 80.900  101.175 1.00 44.57  ? 520 ILE A CD1 1 
ATOM   3544 N  N   . CYS A 1 521 ? 113.318 86.540  101.453 1.00 36.53  ? 521 CYS A N   1 
ATOM   3545 C  CA  . CYS A 1 521 ? 112.506 87.724  101.714 1.00 34.67  ? 521 CYS A CA  1 
ATOM   3546 C  C   . CYS A 1 521 ? 112.772 88.828  100.697 1.00 41.24  ? 521 CYS A C   1 
ATOM   3547 O  O   . CYS A 1 521 ? 111.848 89.559  100.326 1.00 49.71  ? 521 CYS A O   1 
ATOM   3548 C  CB  . CYS A 1 521 ? 112.758 88.234  103.131 1.00 35.29  ? 521 CYS A CB  1 
ATOM   3549 S  SG  . CYS A 1 521 ? 111.883 87.318  104.415 1.00 50.41  ? 521 CYS A SG  1 
ATOM   3550 N  N   . TRP A 1 522 ? 114.016 88.968  100.239 1.00 44.75  ? 522 TRP A N   1 
ATOM   3551 C  CA  . TRP A 1 522 ? 114.347 90.001  99.266  1.00 34.99  ? 522 TRP A CA  1 
ATOM   3552 C  C   . TRP A 1 522 ? 113.822 89.673  97.877  1.00 38.10  ? 522 TRP A C   1 
ATOM   3553 O  O   . TRP A 1 522 ? 113.409 90.581  97.148  1.00 47.97  ? 522 TRP A O   1 
ATOM   3554 C  CB  . TRP A 1 522 ? 115.861 90.198  99.201  1.00 37.08  ? 522 TRP A CB  1 
ATOM   3555 C  CG  . TRP A 1 522 ? 116.428 90.965  100.349 1.00 44.06  ? 522 TRP A CG  1 
ATOM   3556 C  CD1 . TRP A 1 522 ? 115.752 91.775  101.208 1.00 46.18  ? 522 TRP A CD1 1 
ATOM   3557 C  CD2 . TRP A 1 522 ? 117.797 90.988  100.767 1.00 48.60  ? 522 TRP A CD2 1 
ATOM   3558 N  NE1 . TRP A 1 522 ? 116.613 92.305  102.136 1.00 45.98  ? 522 TRP A NE1 1 
ATOM   3559 C  CE2 . TRP A 1 522 ? 117.875 91.835  101.887 1.00 45.92  ? 522 TRP A CE2 1 
ATOM   3560 C  CE3 . TRP A 1 522 ? 118.963 90.375  100.302 1.00 44.61  ? 522 TRP A CE3 1 
ATOM   3561 C  CZ2 . TRP A 1 522 ? 119.073 92.086  102.548 1.00 45.62  ? 522 TRP A CZ2 1 
ATOM   3562 C  CZ3 . TRP A 1 522 ? 120.150 90.624  100.960 1.00 46.33  ? 522 TRP A CZ3 1 
ATOM   3563 C  CH2 . TRP A 1 522 ? 120.196 91.473  102.070 1.00 46.09  ? 522 TRP A CH2 1 
ATOM   3564 N  N   . ARG A 1 523 ? 113.836 88.400  97.488  1.00 38.60  ? 523 ARG A N   1 
ATOM   3565 C  CA  . ARG A 1 523 ? 113.434 88.029  96.137  1.00 37.53  ? 523 ARG A CA  1 
ATOM   3566 C  C   . ARG A 1 523 ? 111.930 87.848  95.970  1.00 44.86  ? 523 ARG A C   1 
ATOM   3567 O  O   . ARG A 1 523 ? 111.379 88.266  94.948  1.00 52.99  ? 523 ARG A O   1 
ATOM   3568 C  CB  . ARG A 1 523 ? 114.151 86.747  95.705  1.00 38.65  ? 523 ARG A CB  1 
ATOM   3569 C  CG  . ARG A 1 523 ? 115.661 86.877  95.640  1.00 37.39  ? 523 ARG A CG  1 
ATOM   3570 C  CD  . ARG A 1 523 ? 116.321 85.524  95.458  1.00 34.35  ? 523 ARG A CD  1 
ATOM   3571 N  NE  . ARG A 1 523 ? 115.893 84.873  94.227  1.00 46.70  ? 523 ARG A NE  1 
ATOM   3572 C  CZ  . ARG A 1 523 ? 116.341 83.698  93.807  1.00 48.01  ? 523 ARG A CZ  1 
ATOM   3573 N  NH1 . ARG A 1 523 ? 117.224 83.005  94.507  1.00 51.79  ? 523 ARG A NH1 1 
ATOM   3574 N  NH2 . ARG A 1 523 ? 115.890 83.205  92.658  1.00 42.62  ? 523 ARG A NH2 1 
ATOM   3575 N  N   . PHE A 1 524 ? 111.244 87.235  96.935  1.00 42.64  ? 524 PHE A N   1 
ATOM   3576 C  CA  . PHE A 1 524 ? 109.842 86.875  96.748  1.00 37.95  ? 524 PHE A CA  1 
ATOM   3577 C  C   . PHE A 1 524 ? 108.861 87.397  97.786  1.00 40.54  ? 524 PHE A C   1 
ATOM   3578 O  O   . PHE A 1 524 ? 107.763 87.831  97.422  1.00 52.49  ? 524 PHE A O   1 
ATOM   3579 C  CB  . PHE A 1 524 ? 109.693 85.345  96.749  1.00 42.81  ? 524 PHE A CB  1 
ATOM   3580 C  CG  . PHE A 1 524 ? 110.639 84.643  95.821  1.00 42.82  ? 524 PHE A CG  1 
ATOM   3581 C  CD1 . PHE A 1 524 ? 110.484 84.740  94.450  1.00 42.88  ? 524 PHE A CD1 1 
ATOM   3582 C  CD2 . PHE A 1 524 ? 111.681 83.882  96.318  1.00 37.97  ? 524 PHE A CD2 1 
ATOM   3583 C  CE1 . PHE A 1 524 ? 111.351 84.095  93.594  1.00 43.42  ? 524 PHE A CE1 1 
ATOM   3584 C  CE2 . PHE A 1 524 ? 112.550 83.235  95.467  1.00 42.58  ? 524 PHE A CE2 1 
ATOM   3585 C  CZ  . PHE A 1 524 ? 112.384 83.341  94.103  1.00 42.20  ? 524 PHE A CZ  1 
ATOM   3586 N  N   . VAL A 1 525 ? 109.217 87.371  99.071  1.00 39.67  ? 525 VAL A N   1 
ATOM   3587 C  CA  . VAL A 1 525 ? 108.191 87.520  100.104 1.00 40.62  ? 525 VAL A CA  1 
ATOM   3588 C  C   . VAL A 1 525 ? 107.781 88.980  100.270 1.00 47.53  ? 525 VAL A C   1 
ATOM   3589 O  O   . VAL A 1 525 ? 106.599 89.324  100.152 1.00 61.48  ? 525 VAL A O   1 
ATOM   3590 C  CB  . VAL A 1 525 ? 108.672 86.915  101.434 1.00 48.58  ? 525 VAL A CB  1 
ATOM   3591 C  CG1 . VAL A 1 525 ? 107.629 87.124  102.513 1.00 47.98  ? 525 VAL A CG1 1 
ATOM   3592 C  CG2 . VAL A 1 525 ? 108.961 85.433  101.261 1.00 42.12  ? 525 VAL A CG2 1 
ATOM   3593 N  N   . SER A 1 526 ? 108.741 89.853  100.576 1.00 45.72  ? 526 SER A N   1 
ATOM   3594 C  CA  . SER A 1 526 ? 108.406 91.250  100.854 1.00 47.42  ? 526 SER A CA  1 
ATOM   3595 C  C   . SER A 1 526 ? 107.759 91.962  99.670  1.00 50.43  ? 526 SER A C   1 
ATOM   3596 O  O   . SER A 1 526 ? 106.738 92.647  99.874  1.00 47.63  ? 526 SER A O   1 
ATOM   3597 C  CB  . SER A 1 526 ? 109.658 91.992  101.336 1.00 45.36  ? 526 SER A CB  1 
ATOM   3598 O  OG  . SER A 1 526 ? 110.261 91.326  102.429 1.00 49.54  ? 526 SER A OG  1 
ATOM   3599 N  N   . PRO A 1 527 ? 108.293 91.887  98.440  1.00 54.26  ? 527 PRO A N   1 
ATOM   3600 C  CA  . PRO A 1 527 ? 107.593 92.536  97.319  1.00 50.52  ? 527 PRO A CA  1 
ATOM   3601 C  C   . PRO A 1 527 ? 106.186 92.011  97.103  1.00 51.08  ? 527 PRO A C   1 
ATOM   3602 O  O   . PRO A 1 527 ? 105.276 92.798  96.820  1.00 59.11  ? 527 PRO A O   1 
ATOM   3603 C  CB  . PRO A 1 527 ? 108.504 92.232  96.123  1.00 51.39  ? 527 PRO A CB  1 
ATOM   3604 C  CG  . PRO A 1 527 ? 109.839 92.024  96.715  1.00 48.02  ? 527 PRO A CG  1 
ATOM   3605 C  CD  . PRO A 1 527 ? 109.581 91.318  98.005  1.00 43.95  ? 527 PRO A CD  1 
ATOM   3606 N  N   . ALA A 1 528 ? 105.977 90.700  97.246  1.00 45.44  ? 528 ALA A N   1 
ATOM   3607 C  CA  . ALA A 1 528 ? 104.642 90.139  97.060  1.00 43.05  ? 528 ALA A CA  1 
ATOM   3608 C  C   . ALA A 1 528 ? 103.682 90.629  98.136  1.00 44.25  ? 528 ALA A C   1 
ATOM   3609 O  O   . ALA A 1 528 ? 102.522 90.940  97.845  1.00 54.39  ? 528 ALA A O   1 
ATOM   3610 C  CB  . ALA A 1 528 ? 104.709 88.614  97.052  1.00 38.69  ? 528 ALA A CB  1 
ATOM   3611 N  N   . ILE A 1 529 ? 104.149 90.706  99.383  1.00 40.67  ? 529 ILE A N   1 
ATOM   3612 C  CA  . ILE A 1 529 ? 103.299 91.186  100.470 1.00 43.56  ? 529 ILE A CA  1 
ATOM   3613 C  C   . ILE A 1 529 ? 102.899 92.637  100.229 1.00 46.08  ? 529 ILE A C   1 
ATOM   3614 O  O   . ILE A 1 529 ? 101.727 93.014  100.381 1.00 51.81  ? 529 ILE A O   1 
ATOM   3615 C  CB  . ILE A 1 529 ? 104.013 91.011  101.823 1.00 43.88  ? 529 ILE A CB  1 
ATOM   3616 C  CG1 . ILE A 1 529 ? 103.780 89.604  102.371 1.00 46.32  ? 529 ILE A CG1 1 
ATOM   3617 C  CG2 . ILE A 1 529 ? 103.540 92.048  102.818 1.00 39.47  ? 529 ILE A CG2 1 
ATOM   3618 C  CD1 . ILE A 1 529 ? 104.670 89.253  103.537 1.00 49.53  ? 529 ILE A CD1 1 
ATOM   3619 N  N   . ILE A 1 530 ? 103.866 93.473  99.841  1.00 43.48  ? 530 ILE A N   1 
ATOM   3620 C  CA  . ILE A 1 530 ? 103.561 94.882  99.599  1.00 43.27  ? 530 ILE A CA  1 
ATOM   3621 C  C   . ILE A 1 530 ? 102.613 95.029  98.413  1.00 48.95  ? 530 ILE A C   1 
ATOM   3622 O  O   . ILE A 1 530 ? 101.681 95.844  98.442  1.00 45.71  ? 530 ILE A O   1 
ATOM   3623 C  CB  . ILE A 1 530 ? 104.859 95.689  99.406  1.00 43.81  ? 530 ILE A CB  1 
ATOM   3624 C  CG1 . ILE A 1 530 ? 105.593 95.827  100.741 1.00 45.45  ? 530 ILE A CG1 1 
ATOM   3625 C  CG2 . ILE A 1 530 ? 104.561 97.063  98.833  1.00 43.73  ? 530 ILE A CG2 1 
ATOM   3626 C  CD1 . ILE A 1 530 ? 107.080 96.044  100.606 1.00 47.59  ? 530 ILE A CD1 1 
ATOM   3627 N  N   . PHE A 1 531 ? 102.826 94.235  97.359  1.00 54.59  ? 531 PHE A N   1 
ATOM   3628 C  CA  . PHE A 1 531 ? 101.931 94.267  96.206  1.00 43.18  ? 531 PHE A CA  1 
ATOM   3629 C  C   . PHE A 1 531 ? 100.511 93.891  96.598  1.00 53.22  ? 531 PHE A C   1 
ATOM   3630 O  O   . PHE A 1 531 ? 99.550  94.535  96.163  1.00 60.89  ? 531 PHE A O   1 
ATOM   3631 C  CB  . PHE A 1 531 ? 102.447 93.323  95.120  1.00 48.82  ? 531 PHE A CB  1 
ATOM   3632 C  CG  . PHE A 1 531 ? 101.599 93.299  93.880  1.00 57.44  ? 531 PHE A CG  1 
ATOM   3633 C  CD1 . PHE A 1 531 ? 101.684 94.316  92.945  1.00 56.32  ? 531 PHE A CD1 1 
ATOM   3634 C  CD2 . PHE A 1 531 ? 100.724 92.253  93.644  1.00 59.13  ? 531 PHE A CD2 1 
ATOM   3635 C  CE1 . PHE A 1 531 ? 100.908 94.294  91.804  1.00 54.55  ? 531 PHE A CE1 1 
ATOM   3636 C  CE2 . PHE A 1 531 ? 99.946  92.226  92.504  1.00 59.40  ? 531 PHE A CE2 1 
ATOM   3637 C  CZ  . PHE A 1 531 ? 100.039 93.248  91.583  1.00 57.74  ? 531 PHE A CZ  1 
ATOM   3638 N  N   . PHE A 1 532 ? 100.356 92.843  97.409  1.00 54.38  ? 532 PHE A N   1 
ATOM   3639 C  CA  . PHE A 1 532 ? 99.020  92.419  97.814  1.00 49.52  ? 532 PHE A CA  1 
ATOM   3640 C  C   . PHE A 1 532 ? 98.336  93.480  98.666  1.00 53.22  ? 532 PHE A C   1 
ATOM   3641 O  O   . PHE A 1 532 ? 97.145  93.762  98.477  1.00 61.83  ? 532 PHE A O   1 
ATOM   3642 C  CB  . PHE A 1 532 ? 99.099  91.090  98.560  1.00 49.50  ? 532 PHE A CB  1 
ATOM   3643 C  CG  . PHE A 1 532 ? 99.024  89.893  97.662  1.00 57.37  ? 532 PHE A CG  1 
ATOM   3644 C  CD1 . PHE A 1 532 ? 98.263  89.927  96.507  1.00 59.88  ? 532 PHE A CD1 1 
ATOM   3645 C  CD2 . PHE A 1 532 ? 99.724  88.739  97.963  1.00 60.49  ? 532 PHE A CD2 1 
ATOM   3646 C  CE1 . PHE A 1 532 ? 98.194  88.831  95.673  1.00 58.54  ? 532 PHE A CE1 1 
ATOM   3647 C  CE2 . PHE A 1 532 ? 99.659  87.638  97.133  1.00 61.14  ? 532 PHE A CE2 1 
ATOM   3648 C  CZ  . PHE A 1 532 ? 98.893  87.685  95.986  1.00 59.58  ? 532 PHE A CZ  1 
ATOM   3649 N  N   . ILE A 1 533 ? 99.073  94.088  99.600  1.00 44.58  ? 533 ILE A N   1 
ATOM   3650 C  CA  . ILE A 1 533 ? 98.489  95.141  100.428 1.00 45.35  ? 533 ILE A CA  1 
ATOM   3651 C  C   . ILE A 1 533 ? 98.039  96.310  99.561  1.00 51.80  ? 533 ILE A C   1 
ATOM   3652 O  O   . ILE A 1 533 ? 96.923  96.824  99.709  1.00 51.32  ? 533 ILE A O   1 
ATOM   3653 C  CB  . ILE A 1 533 ? 99.484  95.594  101.512 1.00 45.07  ? 533 ILE A CB  1 
ATOM   3654 C  CG1 . ILE A 1 533 ? 99.602  94.538  102.610 1.00 40.99  ? 533 ILE A CG1 1 
ATOM   3655 C  CG2 . ILE A 1 533 ? 99.059  96.926  102.105 1.00 39.42  ? 533 ILE A CG2 1 
ATOM   3656 C  CD1 . ILE A 1 533 ? 100.712 94.811  103.593 1.00 38.74  ? 533 ILE A CD1 1 
ATOM   3657 N  N   . LEU A 1 534 ? 98.898  96.739  98.630  1.00 61.41  ? 534 LEU A N   1 
ATOM   3658 C  CA  . LEU A 1 534 ? 98.555  97.869  97.773  1.00 48.31  ? 534 LEU A CA  1 
ATOM   3659 C  C   . LEU A 1 534 ? 97.355  97.555  96.888  1.00 46.86  ? 534 LEU A C   1 
ATOM   3660 O  O   . LEU A 1 534 ? 96.475  98.403  96.703  1.00 56.56  ? 534 LEU A O   1 
ATOM   3661 C  CB  . LEU A 1 534 ? 99.756  98.265  96.917  1.00 50.84  ? 534 LEU A CB  1 
ATOM   3662 C  CG  . LEU A 1 534 ? 99.496  99.391  95.917  1.00 57.78  ? 534 LEU A CG  1 
ATOM   3663 C  CD1 . LEU A 1 534 ? 99.568  100.745 96.605  1.00 59.23  ? 534 LEU A CD1 1 
ATOM   3664 C  CD2 . LEU A 1 534 ? 100.463 99.321  94.749  1.00 59.01  ? 534 LEU A CD2 1 
ATOM   3665 N  N   . VAL A 1 535 ? 97.304  96.346  96.327  1.00 46.98  ? 535 VAL A N   1 
ATOM   3666 C  CA  . VAL A 1 535 ? 96.199  95.983  95.447  1.00 52.54  ? 535 VAL A CA  1 
ATOM   3667 C  C   . VAL A 1 535 ? 94.888  95.943  96.220  1.00 57.48  ? 535 VAL A C   1 
ATOM   3668 O  O   . VAL A 1 535 ? 93.869  96.476  95.763  1.00 62.44  ? 535 VAL A O   1 
ATOM   3669 C  CB  . VAL A 1 535 ? 96.489  94.641  94.751  1.00 59.04  ? 535 VAL A CB  1 
ATOM   3670 C  CG1 . VAL A 1 535 ? 95.194  93.951  94.350  1.00 52.32  ? 535 VAL A CG1 1 
ATOM   3671 C  CG2 . VAL A 1 535 ? 97.373  94.858  93.537  1.00 59.28  ? 535 VAL A CG2 1 
ATOM   3672 N  N   . PHE A 1 536 ? 94.886  95.328  97.403  1.00 67.30  ? 536 PHE A N   1 
ATOM   3673 C  CA  . PHE A 1 536 ? 93.642  95.199  98.150  1.00 58.04  ? 536 PHE A CA  1 
ATOM   3674 C  C   . PHE A 1 536 ? 93.226  96.492  98.836  1.00 63.30  ? 536 PHE A C   1 
ATOM   3675 O  O   . PHE A 1 536 ? 92.056  96.628  99.206  1.00 68.35  ? 536 PHE A O   1 
ATOM   3676 C  CB  . PHE A 1 536 ? 93.760  94.072  99.174  1.00 56.21  ? 536 PHE A CB  1 
ATOM   3677 C  CG  . PHE A 1 536 ? 93.490  92.714  98.600  1.00 60.24  ? 536 PHE A CG  1 
ATOM   3678 C  CD1 . PHE A 1 536 ? 92.249  92.409  98.070  1.00 62.81  ? 536 PHE A CD1 1 
ATOM   3679 C  CD2 . PHE A 1 536 ? 94.479  91.749  98.574  1.00 63.44  ? 536 PHE A CD2 1 
ATOM   3680 C  CE1 . PHE A 1 536 ? 91.997  91.163  97.533  1.00 63.19  ? 536 PHE A CE1 1 
ATOM   3681 C  CE2 . PHE A 1 536 ? 94.233  90.500  98.039  1.00 64.66  ? 536 PHE A CE2 1 
ATOM   3682 C  CZ  . PHE A 1 536 ? 92.990  90.208  97.518  1.00 62.45  ? 536 PHE A CZ  1 
ATOM   3683 N  N   . THR A 1 537 ? 94.147  97.441  99.017  1.00 66.44  ? 537 THR A N   1 
ATOM   3684 C  CA  . THR A 1 537 ? 93.758  98.749  99.530  1.00 65.77  ? 537 THR A CA  1 
ATOM   3685 C  C   . THR A 1 537 ? 92.868  99.510  98.554  1.00 69.03  ? 537 THR A C   1 
ATOM   3686 O  O   . THR A 1 537 ? 91.871  100.104 98.976  1.00 74.62  ? 537 THR A O   1 
ATOM   3687 C  CB  . THR A 1 537 ? 95.003  99.576  99.859  1.00 66.54  ? 537 THR A CB  1 
ATOM   3688 O  OG1 . THR A 1 537 ? 95.643  99.034  101.019 1.00 73.74  ? 537 THR A OG1 1 
ATOM   3689 C  CG2 . THR A 1 537 ? 94.636  101.026 100.129 1.00 63.04  ? 537 THR A CG2 1 
ATOM   3690 N  N   . VAL A 1 538 ? 93.193  99.489  97.266  1.00 72.85  ? 538 VAL A N   1 
ATOM   3691 C  CA  . VAL A 1 538 ? 92.445  100.217 96.246  1.00 71.50  ? 538 VAL A CA  1 
ATOM   3692 C  C   . VAL A 1 538 ? 91.067  99.608  96.016  1.00 72.43  ? 538 VAL A C   1 
ATOM   3693 O  O   . VAL A 1 538 ? 90.073  100.327 95.911  1.00 76.11  ? 538 VAL A O   1 
ATOM   3694 C  CB  . VAL A 1 538 ? 93.262  100.277 94.935  1.00 69.15  ? 538 VAL A CB  1 
ATOM   3695 C  CG1 . VAL A 1 538 ? 92.349  100.454 93.733  1.00 70.05  ? 538 VAL A CG1 1 
ATOM   3696 C  CG2 . VAL A 1 538 ? 94.287  101.396 95.002  1.00 66.28  ? 538 VAL A CG2 1 
ATOM   3697 N  N   . ILE A 1 539 ? 90.988  98.277  95.941  1.00 68.41  ? 539 ILE A N   1 
ATOM   3698 C  CA  . ILE A 1 539 ? 89.715  97.613  95.666  1.00 67.76  ? 539 ILE A CA  1 
ATOM   3699 C  C   . ILE A 1 539 ? 88.718  97.843  96.791  1.00 75.45  ? 539 ILE A C   1 
ATOM   3700 O  O   . ILE A 1 539 ? 87.521  98.033  96.543  1.00 80.25  ? 539 ILE A O   1 
ATOM   3701 C  CB  . ILE A 1 539 ? 89.945  96.108  95.416  1.00 69.90  ? 539 ILE A CB  1 
ATOM   3702 C  CG1 . ILE A 1 539 ? 90.865  95.903  94.211  1.00 75.72  ? 539 ILE A CG1 1 
ATOM   3703 C  CG2 . ILE A 1 539 ? 88.624  95.385  95.209  1.00 67.81  ? 539 ILE A CG2 1 
ATOM   3704 C  CD1 . ILE A 1 539 ? 91.107  94.451  93.870  1.00 73.82  ? 539 ILE A CD1 1 
ATOM   3705 N  N   . GLN A 1 540 ? 89.185  97.841  98.036  1.00 78.72  ? 540 GLN A N   1 
ATOM   3706 C  CA  . GLN A 1 540 ? 88.328  97.985  99.207  1.00 76.89  ? 540 GLN A CA  1 
ATOM   3707 C  C   . GLN A 1 540 ? 88.252  99.435  99.676  1.00 79.56  ? 540 GLN A C   1 
ATOM   3708 O  O   . GLN A 1 540 ? 88.053  99.708  100.860 1.00 82.27  ? 540 GLN A O   1 
ATOM   3709 C  CB  . GLN A 1 540 ? 88.815  97.090  100.343 1.00 75.16  ? 540 GLN A CB  1 
ATOM   3710 C  CG  . GLN A 1 540 ? 88.881  95.615  99.997  1.00 75.33  ? 540 GLN A CG  1 
ATOM   3711 C  CD  . GLN A 1 540 ? 89.183  94.751  101.205 1.00 76.76  ? 540 GLN A CD  1 
ATOM   3712 O  OE1 . GLN A 1 540 ? 89.294  95.249  102.324 1.00 79.91  ? 540 GLN A OE1 1 
ATOM   3713 N  NE2 . GLN A 1 540 ? 89.316  93.450  100.985 1.00 75.92  ? 540 GLN A NE2 1 
ATOM   3714 N  N   . TYR A 1 541 ? 88.401  100.382 98.755  1.00 85.50  ? 541 TYR A N   1 
ATOM   3715 C  CA  . TYR A 1 541 ? 88.421  101.799 99.092  1.00 86.12  ? 541 TYR A CA  1 
ATOM   3716 C  C   . TYR A 1 541 ? 87.000  102.346 99.080  1.00 89.55  ? 541 TYR A C   1 
ATOM   3717 O  O   . TYR A 1 541 ? 86.333  102.331 98.040  1.00 87.95  ? 541 TYR A O   1 
ATOM   3718 C  CB  . TYR A 1 541 ? 89.303  102.585 98.121  1.00 84.04  ? 541 TYR A CB  1 
ATOM   3719 C  CG  . TYR A 1 541 ? 89.582  104.001 98.570  1.00 85.47  ? 541 TYR A CG  1 
ATOM   3720 C  CD1 . TYR A 1 541 ? 90.667  104.289 99.386  1.00 86.51  ? 541 TYR A CD1 1 
ATOM   3721 C  CD2 . TYR A 1 541 ? 88.757  105.049 98.184  1.00 87.26  ? 541 TYR A CD2 1 
ATOM   3722 C  CE1 . TYR A 1 541 ? 90.926  105.580 99.800  1.00 87.77  ? 541 TYR A CE1 1 
ATOM   3723 C  CE2 . TYR A 1 541 ? 89.007  106.343 98.595  1.00 88.39  ? 541 TYR A CE2 1 
ATOM   3724 C  CZ  . TYR A 1 541 ? 90.092  106.603 99.404  1.00 89.71  ? 541 TYR A CZ  1 
ATOM   3725 O  OH  . TYR A 1 541 ? 90.345  107.890 99.815  1.00 87.21  ? 541 TYR A OH  1 
ATOM   3726 N  N   . GLN A 1 542 ? 86.546  102.832 100.235 1.00 95.71  ? 542 GLN A N   1 
ATOM   3727 C  CA  . GLN A 1 542 ? 85.251  103.465 100.404 1.00 95.91  ? 542 GLN A CA  1 
ATOM   3728 C  C   . GLN A 1 542 ? 85.423  104.893 100.915 1.00 96.30  ? 542 GLN A C   1 
ATOM   3729 O  O   . GLN A 1 542 ? 86.161  105.128 101.876 1.00 92.69  ? 542 GLN A O   1 
ATOM   3730 C  CB  . GLN A 1 542 ? 84.369  102.684 101.386 1.00 94.53  ? 542 GLN A CB  1 
ATOM   3731 C  CG  . GLN A 1 542 ? 83.629  101.504 100.777 1.00 94.68  ? 542 GLN A CG  1 
ATOM   3732 C  CD  . GLN A 1 542 ? 83.311  101.699 99.309  1.00 96.70  ? 542 GLN A CD  1 
ATOM   3733 O  OE1 . GLN A 1 542 ? 83.890  101.040 98.445  1.00 95.67  ? 542 GLN A OE1 1 
ATOM   3734 N  NE2 . GLN A 1 542 ? 82.382  102.602 99.017  1.00 96.39  ? 542 GLN A NE2 1 
ATOM   3735 N  N   . PRO A 1 543 ? 84.771  105.870 100.276 1.00 99.75  ? 543 PRO A N   1 
ATOM   3736 C  CA  . PRO A 1 543 ? 84.890  107.257 100.754 1.00 97.74  ? 543 PRO A CA  1 
ATOM   3737 C  C   . PRO A 1 543 ? 84.491  107.437 102.207 1.00 97.44  ? 543 PRO A C   1 
ATOM   3738 O  O   . PRO A 1 543 ? 85.132  108.220 102.918 1.00 97.97  ? 543 PRO A O   1 
ATOM   3739 C  CB  . PRO A 1 543 ? 83.953  108.035 99.821  1.00 97.22  ? 543 PRO A CB  1 
ATOM   3740 C  CG  . PRO A 1 543 ? 83.807  107.196 98.602  1.00 96.20  ? 543 PRO A CG  1 
ATOM   3741 C  CD  . PRO A 1 543 ? 84.192  105.781 98.925  1.00 97.60  ? 543 PRO A CD  1 
ATOM   3742 N  N   . ILE A 1 544 ? 83.453  106.743 102.671 1.00 100.00 ? 544 ILE A N   1 
ATOM   3743 C  CA  . ILE A 1 544 ? 82.996  106.868 104.051 1.00 99.28  ? 544 ILE A CA  1 
ATOM   3744 C  C   . ILE A 1 544 ? 84.011  106.209 104.978 1.00 100.65 ? 544 ILE A C   1 
ATOM   3745 O  O   . ILE A 1 544 ? 84.306  106.725 106.061 1.00 100.21 ? 544 ILE A O   1 
ATOM   3746 C  CB  . ILE A 1 544 ? 81.587  106.266 104.229 1.00 101.16 ? 544 ILE A CB  1 
ATOM   3747 C  CG1 . ILE A 1 544 ? 80.533  107.066 103.449 1.00 102.96 ? 544 ILE A CG1 1 
ATOM   3748 C  CG2 . ILE A 1 544 ? 81.236  106.155 105.712 1.00 98.87  ? 544 ILE A CG2 1 
ATOM   3749 C  CD1 . ILE A 1 544 ? 79.172  106.401 103.352 1.00 102.48 ? 544 ILE A CD1 1 
ATOM   3750 N  N   . THR A 1 545 ? 84.555  105.067 104.555 1.00 100.35 ? 545 THR A N   1 
ATOM   3751 C  CA  . THR A 1 545 ? 85.488  104.307 105.376 1.00 99.46  ? 545 THR A CA  1 
ATOM   3752 C  C   . THR A 1 545 ? 86.877  104.930 105.442 1.00 99.12  ? 545 THR A C   1 
ATOM   3753 O  O   . THR A 1 545 ? 87.463  104.987 106.530 1.00 98.89  ? 545 THR A O   1 
ATOM   3754 C  CB  . THR A 1 545 ? 85.591  102.868 104.850 1.00 99.88  ? 545 THR A CB  1 
ATOM   3755 O  OG1 . THR A 1 545 ? 84.489  102.099 105.347 1.00 100.18 ? 545 THR A OG1 1 
ATOM   3756 C  CG2 . THR A 1 545 ? 86.891  102.210 105.290 1.00 97.43  ? 545 THR A CG2 1 
ATOM   3757 N  N   . TYR A 1 546 ? 87.404  105.419 104.323 1.00 92.23  ? 546 TYR A N   1 
ATOM   3758 C  CA  . TYR A 1 546 ? 88.771  105.917 104.242 1.00 94.57  ? 546 TYR A CA  1 
ATOM   3759 C  C   . TYR A 1 546 ? 88.834  107.425 104.455 1.00 96.63  ? 546 TYR A C   1 
ATOM   3760 O  O   . TYR A 1 546 ? 89.707  108.110 103.918 1.00 98.16  ? 546 TYR A O   1 
ATOM   3761 C  CB  . TYR A 1 546 ? 89.408  105.540 102.907 1.00 94.17  ? 546 TYR A CB  1 
ATOM   3762 C  CG  . TYR A 1 546 ? 89.950  104.130 102.857 1.00 97.02  ? 546 TYR A CG  1 
ATOM   3763 C  CD1 . TYR A 1 546 ? 89.112  103.052 102.615 1.00 93.01  ? 546 TYR A CD1 1 
ATOM   3764 C  CD2 . TYR A 1 546 ? 91.303  103.879 103.045 1.00 94.20  ? 546 TYR A CD2 1 
ATOM   3765 C  CE1 . TYR A 1 546 ? 89.604  101.763 102.566 1.00 91.88  ? 546 TYR A CE1 1 
ATOM   3766 C  CE2 . TYR A 1 546 ? 91.804  102.594 102.997 1.00 94.48  ? 546 TYR A CE2 1 
ATOM   3767 C  CZ  . TYR A 1 546 ? 90.950  101.540 102.757 1.00 96.10  ? 546 TYR A CZ  1 
ATOM   3768 O  OH  . TYR A 1 546 ? 91.442  100.257 102.709 1.00 94.48  ? 546 TYR A OH  1 
ATOM   3769 N  N   . ASN A 1 547 ? 87.903  107.964 105.236 1.00 87.50  ? 547 ASN A N   1 
ATOM   3770 C  CA  . ASN A 1 547 ? 87.980  109.351 105.676 1.00 84.44  ? 547 ASN A CA  1 
ATOM   3771 C  C   . ASN A 1 547 ? 88.171  109.461 107.180 1.00 90.87  ? 547 ASN A C   1 
ATOM   3772 O  O   . ASN A 1 547 ? 89.128  110.100 107.633 1.00 90.56  ? 547 ASN A O   1 
ATOM   3773 C  CB  . ASN A 1 547 ? 86.721  110.116 105.242 1.00 84.89  ? 547 ASN A CB  1 
ATOM   3774 C  CG  . ASN A 1 547 ? 87.020  111.544 104.834 1.00 87.17  ? 547 ASN A CG  1 
ATOM   3775 O  OD1 . ASN A 1 547 ? 87.795  112.238 105.491 1.00 90.31  ? 547 ASN A OD1 1 
ATOM   3776 N  ND2 . ASN A 1 547 ? 86.409  111.990 103.744 1.00 83.55  ? 547 ASN A ND2 1 
ATOM   3777 N  N   . HIS A 1 548 ? 87.267  108.871 107.966 1.00 92.10  ? 548 HIS A N   1 
ATOM   3778 C  CA  . HIS A 1 548 ? 87.442  108.648 109.400 1.00 89.45  ? 548 HIS A CA  1 
ATOM   3779 C  C   . HIS A 1 548 ? 87.465  109.942 110.209 1.00 88.18  ? 548 HIS A C   1 
ATOM   3780 O  O   . HIS A 1 548 ? 87.493  109.901 111.443 1.00 89.09  ? 548 HIS A O   1 
ATOM   3781 C  CB  . HIS A 1 548 ? 88.723  107.844 109.653 1.00 86.84  ? 548 HIS A CB  1 
ATOM   3782 C  CG  . HIS A 1 548 ? 88.827  107.284 111.038 1.00 87.08  ? 548 HIS A CG  1 
ATOM   3783 N  ND1 . HIS A 1 548 ? 87.782  107.317 111.937 1.00 87.89  ? 548 HIS A ND1 1 
ATOM   3784 C  CD2 . HIS A 1 548 ? 89.854  106.677 111.678 1.00 89.14  ? 548 HIS A CD2 1 
ATOM   3785 C  CE1 . HIS A 1 548 ? 88.161  106.755 113.070 1.00 88.54  ? 548 HIS A CE1 1 
ATOM   3786 N  NE2 . HIS A 1 548 ? 89.413  106.358 112.940 1.00 91.23  ? 548 HIS A NE2 1 
ATOM   3787 N  N   . TYR A 1 549 ? 87.442  111.093 109.541 1.00 72.66  ? 549 TYR A N   1 
ATOM   3788 C  CA  . TYR A 1 549 ? 87.454  112.381 110.219 1.00 73.83  ? 549 TYR A CA  1 
ATOM   3789 C  C   . TYR A 1 549 ? 86.537  113.404 109.561 1.00 82.25  ? 549 TYR A C   1 
ATOM   3790 O  O   . TYR A 1 549 ? 86.589  114.585 109.918 1.00 82.60  ? 549 TYR A O   1 
ATOM   3791 C  CB  . TYR A 1 549 ? 88.882  112.922 110.298 1.00 74.32  ? 549 TYR A CB  1 
ATOM   3792 C  CG  . TYR A 1 549 ? 89.811  112.050 111.112 1.00 74.97  ? 549 TYR A CG  1 
ATOM   3793 C  CD1 . TYR A 1 549 ? 89.754  112.047 112.498 1.00 76.60  ? 549 TYR A CD1 1 
ATOM   3794 C  CD2 . TYR A 1 549 ? 90.741  111.226 110.494 1.00 75.26  ? 549 TYR A CD2 1 
ATOM   3795 C  CE1 . TYR A 1 549 ? 90.598  111.251 113.246 1.00 78.39  ? 549 TYR A CE1 1 
ATOM   3796 C  CE2 . TYR A 1 549 ? 91.590  110.427 111.234 1.00 80.40  ? 549 TYR A CE2 1 
ATOM   3797 C  CZ  . TYR A 1 549 ? 91.513  110.442 112.609 1.00 79.51  ? 549 TYR A CZ  1 
ATOM   3798 O  OH  . TYR A 1 549 ? 92.356  109.647 113.351 1.00 72.19  ? 549 TYR A OH  1 
ATOM   3799 N  N   . GLN A 1 550 ? 85.693  112.971 108.621 1.00 81.52  ? 550 GLN A N   1 
ATOM   3800 C  CA  . GLN A 1 550 ? 84.720  113.838 107.947 1.00 76.00  ? 550 GLN A CA  1 
ATOM   3801 C  C   . GLN A 1 550 ? 85.376  115.080 107.347 1.00 76.65  ? 550 GLN A C   1 
ATOM   3802 O  O   . GLN A 1 550 ? 84.840  116.186 107.430 1.00 80.72  ? 550 GLN A O   1 
ATOM   3803 C  CB  . GLN A 1 550 ? 83.573  114.233 108.884 1.00 74.28  ? 550 GLN A CB  1 
ATOM   3804 C  CG  . GLN A 1 550 ? 83.319  113.278 110.041 1.00 78.45  ? 550 GLN A CG  1 
ATOM   3805 C  CD  . GLN A 1 550 ? 82.321  112.194 109.691 1.00 81.53  ? 550 GLN A CD  1 
ATOM   3806 O  OE1 . GLN A 1 550 ? 81.603  112.293 108.696 1.00 80.41  ? 550 GLN A OE1 1 
ATOM   3807 N  NE2 . GLN A 1 550 ? 82.269  111.151 110.511 1.00 81.14  ? 550 GLN A NE2 1 
ATOM   3808 N  N   . TYR A 1 551 ? 86.544  114.901 106.736 1.00 59.67  ? 551 TYR A N   1 
ATOM   3809 C  CA  . TYR A 1 551 ? 87.188  115.996 106.034 1.00 57.38  ? 551 TYR A CA  1 
ATOM   3810 C  C   . TYR A 1 551 ? 86.415  116.336 104.762 1.00 62.21  ? 551 TYR A C   1 
ATOM   3811 O  O   . TYR A 1 551 ? 85.771  115.471 104.165 1.00 71.81  ? 551 TYR A O   1 
ATOM   3812 C  CB  . TYR A 1 551 ? 88.629  115.637 105.682 1.00 57.46  ? 551 TYR A CB  1 
ATOM   3813 C  CG  . TYR A 1 551 ? 89.601  115.734 106.834 1.00 61.08  ? 551 TYR A CG  1 
ATOM   3814 C  CD1 . TYR A 1 551 ? 89.266  116.414 107.995 1.00 67.56  ? 551 TYR A CD1 1 
ATOM   3815 C  CD2 . TYR A 1 551 ? 90.857  115.153 106.756 1.00 62.51  ? 551 TYR A CD2 1 
ATOM   3816 C  CE1 . TYR A 1 551 ? 90.155  116.507 109.048 1.00 67.14  ? 551 TYR A CE1 1 
ATOM   3817 C  CE2 . TYR A 1 551 ? 91.751  115.240 107.803 1.00 65.12  ? 551 TYR A CE2 1 
ATOM   3818 C  CZ  . TYR A 1 551 ? 91.395  115.918 108.945 1.00 66.19  ? 551 TYR A CZ  1 
ATOM   3819 O  OH  . TYR A 1 551 ? 92.283  116.007 109.991 1.00 63.91  ? 551 TYR A OH  1 
ATOM   3820 N  N   . PRO A 1 552 ? 86.457  117.590 104.332 1.00 52.49  ? 552 PRO A N   1 
ATOM   3821 C  CA  . PRO A 1 552 ? 85.839  117.972 103.059 1.00 55.24  ? 552 PRO A CA  1 
ATOM   3822 C  C   . PRO A 1 552 ? 86.648  117.435 101.881 1.00 60.58  ? 552 PRO A C   1 
ATOM   3823 O  O   . PRO A 1 552 ? 87.711  116.839 102.040 1.00 63.00  ? 552 PRO A O   1 
ATOM   3824 C  CB  . PRO A 1 552 ? 85.848  119.502 103.106 1.00 51.13  ? 552 PRO A CB  1 
ATOM   3825 C  CG  . PRO A 1 552 ? 86.920  119.850 104.067 1.00 53.30  ? 552 PRO A CG  1 
ATOM   3826 C  CD  . PRO A 1 552 ? 86.937  118.758 105.087 1.00 55.02  ? 552 PRO A CD  1 
ATOM   3827 N  N   . GLY A 1 553 ? 86.113  117.653 100.678 1.00 46.33  ? 553 GLY A N   1 
ATOM   3828 C  CA  . GLY A 1 553 ? 86.738  117.099 99.487  1.00 46.85  ? 553 GLY A CA  1 
ATOM   3829 C  C   . GLY A 1 553 ? 88.095  117.700 99.173  1.00 51.63  ? 553 GLY A C   1 
ATOM   3830 O  O   . GLY A 1 553 ? 89.031  116.982 98.806  1.00 60.10  ? 553 GLY A O   1 
ATOM   3831 N  N   . TRP A 1 554 ? 88.223  119.023 99.298  1.00 37.41  ? 554 TRP A N   1 
ATOM   3832 C  CA  . TRP A 1 554 ? 89.475  119.677 98.932  1.00 43.19  ? 554 TRP A CA  1 
ATOM   3833 C  C   . TRP A 1 554 ? 90.625  119.288 99.853  1.00 47.91  ? 554 TRP A C   1 
ATOM   3834 O  O   . TRP A 1 554 ? 91.761  119.165 99.383  1.00 57.82  ? 554 TRP A O   1 
ATOM   3835 C  CB  . TRP A 1 554 ? 89.292  121.198 98.903  1.00 41.83  ? 554 TRP A CB  1 
ATOM   3836 C  CG  . TRP A 1 554 ? 88.768  121.801 100.169 1.00 47.50  ? 554 TRP A CG  1 
ATOM   3837 C  CD1 . TRP A 1 554 ? 87.463  122.048 100.478 1.00 45.57  ? 554 TRP A CD1 1 
ATOM   3838 C  CD2 . TRP A 1 554 ? 89.538  122.267 101.283 1.00 47.11  ? 554 TRP A CD2 1 
ATOM   3839 N  NE1 . TRP A 1 554 ? 87.372  122.621 101.721 1.00 41.54  ? 554 TRP A NE1 1 
ATOM   3840 C  CE2 . TRP A 1 554 ? 88.632  122.767 102.236 1.00 39.33  ? 554 TRP A CE2 1 
ATOM   3841 C  CE3 . TRP A 1 554 ? 90.906  122.302 101.570 1.00 46.95  ? 554 TRP A CE3 1 
ATOM   3842 C  CZ2 . TRP A 1 554 ? 89.048  123.294 103.454 1.00 43.24  ? 554 TRP A CZ2 1 
ATOM   3843 C  CZ3 . TRP A 1 554 ? 91.315  122.825 102.779 1.00 46.77  ? 554 TRP A CZ3 1 
ATOM   3844 C  CH2 . TRP A 1 554 ? 90.391  123.314 103.706 1.00 42.99  ? 554 TRP A CH2 1 
ATOM   3845 N  N   . ALA A 1 555 ? 90.362  119.075 101.141 1.00 37.54  ? 555 ALA A N   1 
ATOM   3846 C  CA  . ALA A 1 555 ? 91.391  118.582 102.048 1.00 34.84  ? 555 ALA A CA  1 
ATOM   3847 C  C   . ALA A 1 555 ? 91.873  117.187 101.666 1.00 49.17  ? 555 ALA A C   1 
ATOM   3848 O  O   . ALA A 1 555 ? 93.078  116.913 101.707 1.00 56.03  ? 555 ALA A O   1 
ATOM   3849 C  CB  . ALA A 1 555 ? 90.870  118.582 103.485 1.00 41.02  ? 555 ALA A CB  1 
ATOM   3850 N  N   . VAL A 1 556 ? 90.950  116.301 101.284 1.00 49.07  ? 556 VAL A N   1 
ATOM   3851 C  CA  . VAL A 1 556 ? 91.336  114.964 100.842 1.00 47.42  ? 556 VAL A CA  1 
ATOM   3852 C  C   . VAL A 1 556 ? 92.153  115.044 99.558  1.00 50.75  ? 556 VAL A C   1 
ATOM   3853 O  O   . VAL A 1 556 ? 93.126  114.300 99.375  1.00 56.21  ? 556 VAL A O   1 
ATOM   3854 C  CB  . VAL A 1 556 ? 90.087  114.079 100.670 1.00 38.62  ? 556 VAL A CB  1 
ATOM   3855 C  CG1 . VAL A 1 556 ? 90.470  112.711 100.137 1.00 41.72  ? 556 VAL A CG1 1 
ATOM   3856 C  CG2 . VAL A 1 556 ? 89.349  113.949 101.988 1.00 46.04  ? 556 VAL A CG2 1 
ATOM   3857 N  N   . ALA A 1 557 ? 91.774  115.945 98.648  1.00 38.51  ? 557 ALA A N   1 
ATOM   3858 C  CA  . ALA A 1 557 ? 92.547  116.126 97.423  1.00 32.75  ? 557 ALA A CA  1 
ATOM   3859 C  C   . ALA A 1 557 ? 93.959  116.620 97.724  1.00 41.69  ? 557 ALA A C   1 
ATOM   3860 O  O   . ALA A 1 557 ? 94.931  116.162 97.109  1.00 49.78  ? 557 ALA A O   1 
ATOM   3861 C  CB  . ALA A 1 557 ? 91.826  117.094 96.488  1.00 34.97  ? 557 ALA A CB  1 
ATOM   3862 N  N   . ILE A 1 558 ? 94.091  117.557 98.665  1.00 41.67  ? 558 ILE A N   1 
ATOM   3863 C  CA  . ILE A 1 558 ? 95.415  118.045 99.050  1.00 42.51  ? 558 ILE A CA  1 
ATOM   3864 C  C   . ILE A 1 558 ? 96.242  116.919 99.659  1.00 45.17  ? 558 ILE A C   1 
ATOM   3865 O  O   . ILE A 1 558 ? 97.442  116.791 99.385  1.00 48.80  ? 558 ILE A O   1 
ATOM   3866 C  CB  . ILE A 1 558 ? 95.288  119.243 100.009 1.00 35.90  ? 558 ILE A CB  1 
ATOM   3867 C  CG1 . ILE A 1 558 ? 94.760  120.469 99.265  1.00 36.08  ? 558 ILE A CG1 1 
ATOM   3868 C  CG2 . ILE A 1 558 ? 96.625  119.561 100.655 1.00 34.83  ? 558 ILE A CG2 1 
ATOM   3869 C  CD1 . ILE A 1 558 ? 94.457  121.641 100.168 1.00 40.07  ? 558 ILE A CD1 1 
ATOM   3870 N  N   . GLY A 1 559 ? 95.618  116.089 100.496 1.00 40.10  ? 559 GLY A N   1 
ATOM   3871 C  CA  . GLY A 1 559 ? 96.332  114.955 101.063 1.00 36.54  ? 559 GLY A CA  1 
ATOM   3872 C  C   . GLY A 1 559 ? 96.800  113.971 100.007 1.00 44.33  ? 559 GLY A C   1 
ATOM   3873 O  O   . GLY A 1 559 ? 97.916  113.449 100.078 1.00 45.48  ? 559 GLY A O   1 
ATOM   3874 N  N   . PHE A 1 560 ? 95.952  113.705 99.010  1.00 50.00  ? 560 PHE A N   1 
ATOM   3875 C  CA  . PHE A 1 560 ? 96.346  112.825 97.913  1.00 36.41  ? 560 PHE A CA  1 
ATOM   3876 C  C   . PHE A 1 560 ? 97.509  113.411 97.122  1.00 47.23  ? 560 PHE A C   1 
ATOM   3877 O  O   . PHE A 1 560 ? 98.428  112.685 96.725  1.00 51.96  ? 560 PHE A O   1 
ATOM   3878 C  CB  . PHE A 1 560 ? 95.154  112.563 96.994  1.00 35.98  ? 560 PHE A CB  1 
ATOM   3879 C  CG  . PHE A 1 560 ? 94.414  111.296 97.307  1.00 51.21  ? 560 PHE A CG  1 
ATOM   3880 C  CD1 . PHE A 1 560 ? 94.775  110.103 96.707  1.00 58.43  ? 560 PHE A CD1 1 
ATOM   3881 C  CD2 . PHE A 1 560 ? 93.359  111.296 98.201  1.00 50.03  ? 560 PHE A CD2 1 
ATOM   3882 C  CE1 . PHE A 1 560 ? 94.097  108.936 96.991  1.00 58.92  ? 560 PHE A CE1 1 
ATOM   3883 C  CE2 . PHE A 1 560 ? 92.678  110.131 98.490  1.00 50.29  ? 560 PHE A CE2 1 
ATOM   3884 C  CZ  . PHE A 1 560 ? 93.047  108.950 97.884  1.00 55.78  ? 560 PHE A CZ  1 
ATOM   3885 N  N   . LEU A 1 561 ? 97.482  114.723 96.873  1.00 46.28  ? 561 LEU A N   1 
ATOM   3886 C  CA  . LEU A 1 561 ? 98.590  115.360 96.166  1.00 37.40  ? 561 LEU A CA  1 
ATOM   3887 C  C   . LEU A 1 561 ? 99.884  115.267 96.966  1.00 36.01  ? 561 LEU A C   1 
ATOM   3888 O  O   . LEU A 1 561 ? 100.956 115.015 96.400  1.00 43.15  ? 561 LEU A O   1 
ATOM   3889 C  CB  . LEU A 1 561 ? 98.253  116.818 95.857  1.00 42.43  ? 561 LEU A CB  1 
ATOM   3890 C  CG  . LEU A 1 561 ? 97.203  117.047 94.772  1.00 43.21  ? 561 LEU A CG  1 
ATOM   3891 C  CD1 . LEU A 1 561 ? 96.746  118.496 94.766  1.00 49.10  ? 561 LEU A CD1 1 
ATOM   3892 C  CD2 . LEU A 1 561 ? 97.749  116.650 93.413  1.00 46.12  ? 561 LEU A CD2 1 
ATOM   3893 N  N   . MET A 1 562 ? 99.807  115.472 98.283  1.00 41.47  ? 562 MET A N   1 
ATOM   3894 C  CA  . MET A 1 562 ? 100.996 115.337 99.121  1.00 38.09  ? 562 MET A CA  1 
ATOM   3895 C  C   . MET A 1 562 ? 101.525 113.908 99.102  1.00 44.01  ? 562 MET A C   1 
ATOM   3896 O  O   . MET A 1 562 ? 102.741 113.689 99.098  1.00 45.51  ? 562 MET A O   1 
ATOM   3897 C  CB  . MET A 1 562 ? 100.690 115.776 100.553 1.00 33.36  ? 562 MET A CB  1 
ATOM   3898 C  CG  . MET A 1 562 ? 100.322 117.241 100.693 1.00 49.77  ? 562 MET A CG  1 
ATOM   3899 S  SD  . MET A 1 562 ? 100.314 117.803 102.405 1.00 68.24  ? 562 MET A SD  1 
ATOM   3900 C  CE  . MET A 1 562 ? 99.456  116.450 103.200 1.00 46.01  ? 562 MET A CE  1 
ATOM   3901 N  N   . ALA A 1 563 ? 100.626 112.922 99.104  1.00 46.23  ? 563 ALA A N   1 
ATOM   3902 C  CA  . ALA A 1 563 ? 101.057 111.530 99.020  1.00 41.16  ? 563 ALA A CA  1 
ATOM   3903 C  C   . ALA A 1 563 ? 101.737 111.237 97.688  1.00 50.43  ? 563 ALA A C   1 
ATOM   3904 O  O   . ALA A 1 563 ? 102.748 110.526 97.642  1.00 55.50  ? 563 ALA A O   1 
ATOM   3905 C  CB  . ALA A 1 563 ? 99.864  110.597 99.225  1.00 44.69  ? 563 ALA A CB  1 
ATOM   3906 N  N   . LEU A 1 564 ? 101.194 111.769 96.593  1.00 47.92  ? 564 LEU A N   1 
ATOM   3907 C  CA  . LEU A 1 564 ? 101.729 111.484 95.266  1.00 43.76  ? 564 LEU A CA  1 
ATOM   3908 C  C   . LEU A 1 564 ? 102.998 112.264 94.944  1.00 45.17  ? 564 LEU A C   1 
ATOM   3909 O  O   . LEU A 1 564 ? 103.739 111.861 94.040  1.00 51.11  ? 564 LEU A O   1 
ATOM   3910 C  CB  . LEU A 1 564 ? 100.673 111.782 94.200  1.00 43.48  ? 564 LEU A CB  1 
ATOM   3911 C  CG  . LEU A 1 564 ? 99.602  110.720 93.957  1.00 44.30  ? 564 LEU A CG  1 
ATOM   3912 C  CD1 . LEU A 1 564 ? 98.617  111.198 92.906  1.00 44.47  ? 564 LEU A CD1 1 
ATOM   3913 C  CD2 . LEU A 1 564 ? 100.233 109.405 93.543  1.00 47.68  ? 564 LEU A CD2 1 
ATOM   3914 N  N   . SER A 1 565 ? 103.257 113.374 95.642  1.00 43.74  ? 565 SER A N   1 
ATOM   3915 C  CA  . SER A 1 565 ? 104.393 114.220 95.283  1.00 35.91  ? 565 SER A CA  1 
ATOM   3916 C  C   . SER A 1 565 ? 105.724 113.497 95.441  1.00 36.80  ? 565 SER A C   1 
ATOM   3917 O  O   . SER A 1 565 ? 106.628 113.681 94.618  1.00 43.39  ? 565 SER A O   1 
ATOM   3918 C  CB  . SER A 1 565 ? 104.384 115.496 96.124  1.00 41.16  ? 565 SER A CB  1 
ATOM   3919 O  OG  . SER A 1 565 ? 104.565 115.205 97.497  1.00 49.06  ? 565 SER A OG  1 
ATOM   3920 N  N   . SER A 1 566 ? 105.876 112.685 96.485  1.00 45.24  ? 566 SER A N   1 
ATOM   3921 C  CA  . SER A 1 566 ? 107.116 111.944 96.681  1.00 42.51  ? 566 SER A CA  1 
ATOM   3922 C  C   . SER A 1 566 ? 107.228 110.731 95.770  1.00 50.41  ? 566 SER A C   1 
ATOM   3923 O  O   . SER A 1 566 ? 108.324 110.431 95.283  1.00 46.50  ? 566 SER A O   1 
ATOM   3924 C  CB  . SER A 1 566 ? 107.240 111.496 98.139  1.00 37.89  ? 566 SER A CB  1 
ATOM   3925 O  OG  . SER A 1 566 ? 105.973 111.188 98.690  1.00 50.23  ? 566 SER A OG  1 
ATOM   3926 N  N   . VAL A 1 567 ? 106.120 110.029 95.529  1.00 57.23  ? 567 VAL A N   1 
ATOM   3927 C  CA  . VAL A 1 567 ? 106.145 108.849 94.672  1.00 41.95  ? 567 VAL A CA  1 
ATOM   3928 C  C   . VAL A 1 567 ? 106.392 109.201 93.209  1.00 44.03  ? 567 VAL A C   1 
ATOM   3929 O  O   . VAL A 1 567 ? 107.113 108.469 92.520  1.00 58.14  ? 567 VAL A O   1 
ATOM   3930 C  CB  . VAL A 1 567 ? 104.837 108.056 94.841  1.00 48.76  ? 567 VAL A CB  1 
ATOM   3931 C  CG1 . VAL A 1 567 ? 104.541 107.218 93.611  1.00 50.07  ? 567 VAL A CG1 1 
ATOM   3932 C  CG2 . VAL A 1 567 ? 104.915 107.176 96.076  1.00 46.34  ? 567 VAL A CG2 1 
ATOM   3933 N  N   . LEU A 1 568 ? 105.843 110.312 92.717  1.00 43.47  ? 568 LEU A N   1 
ATOM   3934 C  CA  . LEU A 1 568 ? 105.994 110.684 91.315  1.00 45.12  ? 568 LEU A CA  1 
ATOM   3935 C  C   . LEU A 1 568 ? 107.406 111.128 90.953  1.00 54.81  ? 568 LEU A C   1 
ATOM   3936 O  O   . LEU A 1 568 ? 107.657 111.431 89.782  1.00 55.66  ? 568 LEU A O   1 
ATOM   3937 C  CB  . LEU A 1 568 ? 105.005 111.798 90.961  1.00 49.30  ? 568 LEU A CB  1 
ATOM   3938 C  CG  . LEU A 1 568 ? 103.572 111.378 90.631  1.00 52.09  ? 568 LEU A CG  1 
ATOM   3939 C  CD1 . LEU A 1 568 ? 102.857 112.481 89.873  1.00 49.23  ? 568 LEU A CD1 1 
ATOM   3940 C  CD2 . LEU A 1 568 ? 103.557 110.085 89.832  1.00 53.70  ? 568 LEU A CD2 1 
ATOM   3941 N  N   . CYS A 1 569 ? 108.328 111.182 91.915  1.00 51.39  ? 569 CYS A N   1 
ATOM   3942 C  CA  . CYS A 1 569 ? 109.690 111.608 91.611  1.00 40.24  ? 569 CYS A CA  1 
ATOM   3943 C  C   . CYS A 1 569 ? 110.446 110.566 90.795  1.00 45.69  ? 569 CYS A C   1 
ATOM   3944 O  O   . CYS A 1 569 ? 111.374 110.916 90.059  1.00 54.79  ? 569 CYS A O   1 
ATOM   3945 C  CB  . CYS A 1 569 ? 110.445 111.914 92.905  1.00 37.57  ? 569 CYS A CB  1 
ATOM   3946 S  SG  . CYS A 1 569 ? 110.207 113.588 93.533  1.00 55.18  ? 569 CYS A SG  1 
ATOM   3947 N  N   . ILE A 1 570 ? 110.073 109.296 90.911  1.00 45.16  ? 570 ILE A N   1 
ATOM   3948 C  CA  . ILE A 1 570 ? 110.772 108.210 90.224  1.00 47.69  ? 570 ILE A CA  1 
ATOM   3949 C  C   . ILE A 1 570 ? 110.425 108.185 88.736  1.00 49.44  ? 570 ILE A C   1 
ATOM   3950 O  O   . ILE A 1 570 ? 111.340 108.290 87.901  1.00 57.45  ? 570 ILE A O   1 
ATOM   3951 C  CB  . ILE A 1 570 ? 110.479 106.856 90.896  1.00 42.10  ? 570 ILE A CB  1 
ATOM   3952 C  CG1 . ILE A 1 570 ? 110.411 107.024 92.415  1.00 41.50  ? 570 ILE A CG1 1 
ATOM   3953 C  CG2 . ILE A 1 570 ? 111.526 105.826 90.506  1.00 48.54  ? 570 ILE A CG2 1 
ATOM   3954 C  CD1 . ILE A 1 570 ? 110.357 105.723 93.178  1.00 39.17  ? 570 ILE A CD1 1 
ATOM   3955 N  N   . PRO A 1 571 ? 109.150 108.042 88.339  1.00 47.30  ? 571 PRO A N   1 
ATOM   3956 C  CA  . PRO A 1 571 ? 108.855 107.953 86.900  1.00 45.41  ? 571 PRO A CA  1 
ATOM   3957 C  C   . PRO A 1 571 ? 109.242 109.193 86.116  1.00 51.84  ? 571 PRO A C   1 
ATOM   3958 O  O   . PRO A 1 571 ? 109.664 109.059 84.964  1.00 60.02  ? 571 PRO A O   1 
ATOM   3959 C  CB  . PRO A 1 571 ? 107.340 107.720 86.863  1.00 42.78  ? 571 PRO A CB  1 
ATOM   3960 C  CG  . PRO A 1 571 ? 106.847 108.333 88.100  1.00 47.34  ? 571 PRO A CG  1 
ATOM   3961 C  CD  . PRO A 1 571 ? 107.902 108.063 89.128  1.00 46.62  ? 571 PRO A CD  1 
ATOM   3962 N  N   . LEU A 1 572 ? 109.126 110.386 86.696  1.00 47.13  ? 572 LEU A N   1 
ATOM   3963 C  CA  . LEU A 1 572 ? 109.486 111.608 85.989  1.00 51.01  ? 572 LEU A CA  1 
ATOM   3964 C  C   . LEU A 1 572 ? 110.986 111.736 85.768  1.00 54.33  ? 572 LEU A C   1 
ATOM   3965 O  O   . LEU A 1 572 ? 111.418 112.110 84.668  1.00 56.55  ? 572 LEU A O   1 
ATOM   3966 C  CB  . LEU A 1 572 ? 108.970 112.829 86.754  1.00 55.78  ? 572 LEU A CB  1 
ATOM   3967 C  CG  . LEU A 1 572 ? 107.509 113.203 86.495  1.00 54.99  ? 572 LEU A CG  1 
ATOM   3968 C  CD1 . LEU A 1 572 ? 107.025 114.224 87.509  1.00 53.43  ? 572 LEU A CD1 1 
ATOM   3969 C  CD2 . LEU A 1 572 ? 107.331 113.725 85.081  1.00 53.37  ? 572 LEU A CD2 1 
ATOM   3970 N  N   . TYR A 1 573 ? 111.792 111.425 86.786  1.00 46.11  ? 573 TYR A N   1 
ATOM   3971 C  CA  . TYR A 1 573 ? 113.234 111.398 86.586  1.00 43.49  ? 573 TYR A CA  1 
ATOM   3972 C  C   . TYR A 1 573 ? 113.635 110.308 85.603  1.00 56.83  ? 573 TYR A C   1 
ATOM   3973 O  O   . TYR A 1 573 ? 114.637 110.455 84.895  1.00 61.51  ? 573 TYR A O   1 
ATOM   3974 C  CB  . TYR A 1 573 ? 113.957 111.210 87.919  1.00 41.65  ? 573 TYR A CB  1 
ATOM   3975 C  CG  . TYR A 1 573 ? 115.446 111.451 87.830  1.00 49.85  ? 573 TYR A CG  1 
ATOM   3976 C  CD1 . TYR A 1 573 ? 116.322 110.413 87.554  1.00 51.87  ? 573 TYR A CD1 1 
ATOM   3977 C  CD2 . TYR A 1 573 ? 115.973 112.721 88.010  1.00 54.49  ? 573 TYR A CD2 1 
ATOM   3978 C  CE1 . TYR A 1 573 ? 117.679 110.631 87.466  1.00 45.67  ? 573 TYR A CE1 1 
ATOM   3979 C  CE2 . TYR A 1 573 ? 117.330 112.948 87.923  1.00 51.77  ? 573 TYR A CE2 1 
ATOM   3980 C  CZ  . TYR A 1 573 ? 118.178 111.899 87.650  1.00 48.31  ? 573 TYR A CZ  1 
ATOM   3981 O  OH  . TYR A 1 573 ? 119.532 112.119 87.562  1.00 55.80  ? 573 TYR A OH  1 
ATOM   3982 N  N   . ALA A 1 574 ? 112.864 109.218 85.533  1.00 52.51  ? 574 ALA A N   1 
ATOM   3983 C  CA  . ALA A 1 574 ? 113.143 108.195 84.530  1.00 39.26  ? 574 ALA A CA  1 
ATOM   3984 C  C   . ALA A 1 574 ? 113.037 108.757 83.115  1.00 54.31  ? 574 ALA A C   1 
ATOM   3985 O  O   . ALA A 1 574 ? 113.945 108.563 82.298  1.00 63.49  ? 574 ALA A O   1 
ATOM   3986 C  CB  . ALA A 1 574 ? 112.199 107.009 84.712  1.00 45.76  ? 574 ALA A CB  1 
ATOM   3987 N  N   . MET A 1 575 ? 111.945 109.467 82.808  1.00 60.74  ? 575 MET A N   1 
ATOM   3988 C  CA  . MET A 1 575 ? 111.816 110.077 81.486  1.00 63.90  ? 575 MET A CA  1 
ATOM   3989 C  C   . MET A 1 575 ? 112.864 111.157 81.260  1.00 66.18  ? 575 MET A C   1 
ATOM   3990 O  O   . MET A 1 575 ? 113.388 111.285 80.146  1.00 68.71  ? 575 MET A O   1 
ATOM   3991 C  CB  . MET A 1 575 ? 110.419 110.664 81.285  1.00 60.52  ? 575 MET A CB  1 
ATOM   3992 C  CG  . MET A 1 575 ? 109.331 110.039 82.127  1.00 65.95  ? 575 MET A CG  1 
ATOM   3993 S  SD  . MET A 1 575 ? 107.681 110.549 81.611  1.00 92.63  ? 575 MET A SD  1 
ATOM   3994 C  CE  . MET A 1 575 ? 106.673 109.327 82.444  1.00 69.95  ? 575 MET A CE  1 
ATOM   3995 N  N   . PHE A 1 576 ? 113.175 111.945 82.292  1.00 63.88  ? 576 PHE A N   1 
ATOM   3996 C  CA  . PHE A 1 576 ? 114.203 112.968 82.138  1.00 61.21  ? 576 PHE A CA  1 
ATOM   3997 C  C   . PHE A 1 576 ? 115.544 112.349 81.759  1.00 64.54  ? 576 PHE A C   1 
ATOM   3998 O  O   . PHE A 1 576 ? 116.227 112.845 80.857  1.00 66.03  ? 576 PHE A O   1 
ATOM   3999 C  CB  . PHE A 1 576 ? 114.332 113.786 83.422  1.00 64.77  ? 576 PHE A CB  1 
ATOM   4000 C  CG  . PHE A 1 576 ? 115.643 114.508 83.551  1.00 70.88  ? 576 PHE A CG  1 
ATOM   4001 C  CD1 . PHE A 1 576 ? 115.886 115.662 82.827  1.00 66.11  ? 576 PHE A CD1 1 
ATOM   4002 C  CD2 . PHE A 1 576 ? 116.631 114.033 84.397  1.00 68.84  ? 576 PHE A CD2 1 
ATOM   4003 C  CE1 . PHE A 1 576 ? 117.089 116.326 82.942  1.00 65.13  ? 576 PHE A CE1 1 
ATOM   4004 C  CE2 . PHE A 1 576 ? 117.837 114.694 84.515  1.00 70.52  ? 576 PHE A CE2 1 
ATOM   4005 C  CZ  . PHE A 1 576 ? 118.066 115.843 83.787  1.00 69.79  ? 576 PHE A CZ  1 
ATOM   4006 N  N   . ARG A 1 577 ? 115.933 111.262 82.430  1.00 67.40  ? 577 ARG A N   1 
ATOM   4007 C  CA  . ARG A 1 577 ? 117.176 110.584 82.079  1.00 66.93  ? 577 ARG A CA  1 
ATOM   4008 C  C   . ARG A 1 577 ? 117.102 109.956 80.694  1.00 71.29  ? 577 ARG A C   1 
ATOM   4009 O  O   . ARG A 1 577 ? 118.084 109.999 79.945  1.00 71.87  ? 577 ARG A O   1 
ATOM   4010 C  CB  . ARG A 1 577 ? 117.513 109.518 83.120  1.00 62.33  ? 577 ARG A CB  1 
ATOM   4011 C  CG  . ARG A 1 577 ? 118.481 109.988 84.187  1.00 70.56  ? 577 ARG A CG  1 
ATOM   4012 C  CD  . ARG A 1 577 ? 119.846 110.315 83.611  1.00 69.17  ? 577 ARG A CD  1 
ATOM   4013 N  NE  . ARG A 1 577 ? 120.569 109.122 83.190  1.00 72.37  ? 577 ARG A NE  1 
ATOM   4014 C  CZ  . ARG A 1 577 ? 121.860 108.915 83.414  1.00 75.23  ? 577 ARG A CZ  1 
ATOM   4015 N  NH1 . ARG A 1 577 ? 122.599 109.799 84.063  1.00 68.18  ? 577 ARG A NH1 1 
ATOM   4016 N  NH2 . ARG A 1 577 ? 122.422 107.792 82.977  1.00 76.11  ? 577 ARG A NH2 1 
ATOM   4017 N  N   . LEU A 1 578 ? 115.959 109.366 80.339  1.00 76.08  ? 578 LEU A N   1 
ATOM   4018 C  CA  . LEU A 1 578 ? 115.810 108.752 79.026  1.00 72.68  ? 578 LEU A CA  1 
ATOM   4019 C  C   . LEU A 1 578 ? 115.874 109.764 77.892  1.00 75.36  ? 578 LEU A C   1 
ATOM   4020 O  O   . LEU A 1 578 ? 116.248 109.396 76.773  1.00 75.20  ? 578 LEU A O   1 
ATOM   4021 C  CB  . LEU A 1 578 ? 114.490 107.985 78.951  1.00 68.36  ? 578 LEU A CB  1 
ATOM   4022 C  CG  . LEU A 1 578 ? 114.468 106.619 79.635  1.00 69.67  ? 578 LEU A CG  1 
ATOM   4023 C  CD1 . LEU A 1 578 ? 113.060 106.051 79.649  1.00 72.56  ? 578 LEU A CD1 1 
ATOM   4024 C  CD2 . LEU A 1 578 ? 115.428 105.668 78.947  1.00 74.91  ? 578 LEU A CD2 1 
ATOM   4025 N  N   . CYS A 1 579 ? 115.520 111.024 78.150  1.00 78.25  ? 579 CYS A N   1 
ATOM   4026 C  CA  . CYS A 1 579 ? 115.567 112.040 77.106  1.00 77.77  ? 579 CYS A CA  1 
ATOM   4027 C  C   . CYS A 1 579 ? 116.986 112.468 76.751  1.00 78.41  ? 579 CYS A C   1 
ATOM   4028 O  O   . CYS A 1 579 ? 117.178 113.128 75.725  1.00 80.95  ? 579 CYS A O   1 
ATOM   4029 C  CB  . CYS A 1 579 ? 114.753 113.264 77.526  1.00 80.53  ? 579 CYS A CB  1 
ATOM   4030 S  SG  . CYS A 1 579 ? 112.967 113.072 77.333  1.00 83.50  ? 579 CYS A SG  1 
ATOM   4031 N  N   . ARG A 1 580 ? 117.978 112.117 77.569  1.00 84.00  ? 580 ARG A N   1 
ATOM   4032 C  CA  . ARG A 1 580 ? 119.365 112.493 77.328  1.00 82.75  ? 580 ARG A CA  1 
ATOM   4033 C  C   . ARG A 1 580 ? 120.282 111.292 77.125  1.00 85.92  ? 580 ARG A C   1 
ATOM   4034 O  O   . ARG A 1 580 ? 121.500 111.426 77.275  1.00 85.60  ? 580 ARG A O   1 
ATOM   4035 C  CB  . ARG A 1 580 ? 119.890 113.351 78.481  1.00 81.13  ? 580 ARG A CB  1 
ATOM   4036 C  CG  . ARG A 1 580 ? 118.807 113.987 79.332  1.00 83.17  ? 580 ARG A CG  1 
ATOM   4037 C  CD  . ARG A 1 580 ? 119.285 115.294 79.941  1.00 85.83  ? 580 ARG A CD  1 
ATOM   4038 N  NE  . ARG A 1 580 ? 119.139 116.415 79.021  1.00 90.53  ? 580 ARG A NE  1 
ATOM   4039 C  CZ  . ARG A 1 580 ? 118.095 117.232 78.993  1.00 89.61  ? 580 ARG A CZ  1 
ATOM   4040 N  NH1 . ARG A 1 580 ? 117.075 117.078 79.820  1.00 85.43  ? 580 ARG A NH1 1 
ATOM   4041 N  NH2 . ARG A 1 580 ? 118.074 118.228 78.111  1.00 86.57  ? 580 ARG A NH2 1 
ATOM   4042 N  N   . THR A 1 581 ? 119.732 110.128 76.796  1.00 89.25  ? 581 THR A N   1 
ATOM   4043 C  CA  . THR A 1 581 ? 120.516 108.917 76.607  1.00 86.72  ? 581 THR A CA  1 
ATOM   4044 C  C   . THR A 1 581 ? 120.573 108.545 75.130  1.00 89.17  ? 581 THR A C   1 
ATOM   4045 O  O   . THR A 1 581 ? 119.557 108.549 74.430  1.00 91.26  ? 581 THR A O   1 
ATOM   4046 C  CB  . THR A 1 581 ? 119.930 107.758 77.417  1.00 86.17  ? 581 THR A CB  1 
ATOM   4047 O  OG1 . THR A 1 581 ? 120.032 108.053 78.815  1.00 85.71  ? 581 THR A OG1 1 
ATOM   4048 C  CG2 . THR A 1 581 ? 120.676 106.467 77.128  1.00 83.59  ? 581 THR A CG2 1 
ATOM   4049 N  N   . ASP A 1 582 ? 121.775 108.224 74.662  1.00 99.90  ? 582 ASP A N   1 
ATOM   4050 C  CA  . ASP A 1 582 ? 121.995 107.847 73.274  1.00 102.59 ? 582 ASP A CA  1 
ATOM   4051 C  C   . ASP A 1 582 ? 121.367 106.490 72.979  1.00 102.37 ? 582 ASP A C   1 
ATOM   4052 O  O   . ASP A 1 582 ? 121.199 105.653 73.869  1.00 104.87 ? 582 ASP A O   1 
ATOM   4053 C  CB  . ASP A 1 582 ? 123.490 107.806 72.956  1.00 102.04 ? 582 ASP A CB  1 
ATOM   4054 C  CG  . ASP A 1 582 ? 124.037 109.161 72.554  1.00 105.41 ? 582 ASP A CG  1 
ATOM   4055 O  OD1 . ASP A 1 582 ? 123.394 109.843 71.729  1.00 103.39 ? 582 ASP A OD1 1 
ATOM   4056 O  OD2 . ASP A 1 582 ? 125.112 109.543 73.062  1.00 105.01 ? 582 ASP A OD2 1 
ATOM   4057 N  N   . GLY A 1 583 ? 121.021 106.280 71.711  1.00 103.90 ? 583 GLY A N   1 
ATOM   4058 C  CA  . GLY A 1 583 ? 120.410 105.035 71.290  1.00 104.76 ? 583 GLY A CA  1 
ATOM   4059 C  C   . GLY A 1 583 ? 119.298 105.228 70.279  1.00 106.14 ? 583 GLY A C   1 
ATOM   4060 O  O   . GLY A 1 583 ? 118.416 106.070 70.472  1.00 106.21 ? 583 GLY A O   1 
ATOM   4061 N  N   . ASP A 1 584 ? 119.337 104.460 69.189  1.00 111.75 ? 584 ASP A N   1 
ATOM   4062 C  CA  . ASP A 1 584 ? 118.313 104.577 68.155  1.00 111.22 ? 584 ASP A CA  1 
ATOM   4063 C  C   . ASP A 1 584 ? 116.944 104.170 68.687  1.00 111.97 ? 584 ASP A C   1 
ATOM   4064 O  O   . ASP A 1 584 ? 116.013 104.981 68.738  1.00 113.90 ? 584 ASP A O   1 
ATOM   4065 C  CB  . ASP A 1 584 ? 118.698 103.731 66.941  1.00 110.17 ? 584 ASP A CB  1 
ATOM   4066 C  CG  . ASP A 1 584 ? 119.841 104.333 66.150  1.00 113.80 ? 584 ASP A CG  1 
ATOM   4067 O  OD1 . ASP A 1 584 ? 120.159 105.520 66.373  1.00 114.47 ? 584 ASP A OD1 1 
ATOM   4068 O  OD2 . ASP A 1 584 ? 120.421 103.620 65.304  1.00 115.88 ? 584 ASP A OD2 1 
ATOM   4069 N  N   . THR A 1 585 ? 116.803 102.910 69.089  1.00 102.73 ? 585 THR A N   1 
ATOM   4070 C  CA  . THR A 1 585 ? 115.530 102.411 69.580  1.00 104.00 ? 585 THR A CA  1 
ATOM   4071 C  C   . THR A 1 585 ? 115.354 102.739 71.060  1.00 102.58 ? 585 THR A C   1 
ATOM   4072 O  O   . THR A 1 585 ? 116.312 103.036 71.778  1.00 104.24 ? 585 THR A O   1 
ATOM   4073 C  CB  . THR A 1 585 ? 115.424 100.901 69.366  1.00 104.57 ? 585 THR A CB  1 
ATOM   4074 O  OG1 . THR A 1 585 ? 116.507 100.244 70.037  1.00 104.89 ? 585 THR A OG1 1 
ATOM   4075 C  CG2 . THR A 1 585 ? 115.481 100.569 67.883  1.00 103.65 ? 585 THR A CG2 1 
ATOM   4076 N  N   . LEU A 1 586 ? 114.098 102.689 71.511  1.00 90.95  ? 586 LEU A N   1 
ATOM   4077 C  CA  . LEU A 1 586 ? 113.808 102.884 72.926  1.00 90.22  ? 586 LEU A CA  1 
ATOM   4078 C  C   . LEU A 1 586 ? 114.353 101.750 73.783  1.00 91.62  ? 586 LEU A C   1 
ATOM   4079 O  O   . LEU A 1 586 ? 114.806 101.998 74.906  1.00 98.00  ? 586 LEU A O   1 
ATOM   4080 C  CB  . LEU A 1 586 ? 112.300 103.028 73.140  1.00 90.45  ? 586 LEU A CB  1 
ATOM   4081 C  CG  . LEU A 1 586 ? 111.793 102.966 74.582  1.00 90.42  ? 586 LEU A CG  1 
ATOM   4082 C  CD1 . LEU A 1 586 ? 112.127 104.250 75.323  1.00 89.16  ? 586 LEU A CD1 1 
ATOM   4083 C  CD2 . LEU A 1 586 ? 110.299 102.700 74.617  1.00 92.02  ? 586 LEU A CD2 1 
ATOM   4084 N  N   . LEU A 1 587 ? 114.327 100.516 73.277  1.00 90.56  ? 587 LEU A N   1 
ATOM   4085 C  CA  . LEU A 1 587 ? 114.890 99.393  74.015  1.00 92.30  ? 587 LEU A CA  1 
ATOM   4086 C  C   . LEU A 1 587 ? 116.388 99.555  74.239  1.00 93.17  ? 587 LEU A C   1 
ATOM   4087 O  O   . LEU A 1 587 ? 116.890 99.215  75.316  1.00 91.90  ? 587 LEU A O   1 
ATOM   4088 C  CB  . LEU A 1 587 ? 114.605 98.084  73.278  1.00 91.51  ? 587 LEU A CB  1 
ATOM   4089 C  CG  . LEU A 1 587 ? 115.183 96.814  73.901  1.00 92.30  ? 587 LEU A CG  1 
ATOM   4090 C  CD1 . LEU A 1 587 ? 114.234 96.259  74.951  1.00 91.15  ? 587 LEU A CD1 1 
ATOM   4091 C  CD2 . LEU A 1 587 ? 115.478 95.774  72.832  1.00 93.49  ? 587 LEU A CD2 1 
ATOM   4092 N  N   . GLN A 1 588 ? 117.114 100.070 73.244  1.00 89.77  ? 588 GLN A N   1 
ATOM   4093 C  CA  . GLN A 1 588 ? 118.533 100.350 73.415  1.00 89.97  ? 588 GLN A CA  1 
ATOM   4094 C  C   . GLN A 1 588 ? 118.790 101.467 74.415  1.00 88.91  ? 588 GLN A C   1 
ATOM   4095 O  O   . GLN A 1 588 ? 119.766 101.393 75.169  1.00 89.99  ? 588 GLN A O   1 
ATOM   4096 C  CB  . GLN A 1 588 ? 119.169 100.710 72.069  1.00 90.02  ? 588 GLN A CB  1 
ATOM   4097 C  CG  . GLN A 1 588 ? 120.690 100.812 72.093  1.00 91.37  ? 588 GLN A CG  1 
ATOM   4098 C  CD  . GLN A 1 588 ? 121.371 99.520  72.510  1.00 93.65  ? 588 GLN A CD  1 
ATOM   4099 O  OE1 . GLN A 1 588 ? 120.853 98.429  72.271  1.00 94.00  ? 588 GLN A OE1 1 
ATOM   4100 N  NE2 . GLN A 1 588 ? 122.526 99.637  73.154  1.00 91.09  ? 588 GLN A NE2 1 
ATOM   4101 N  N   . ARG A 1 589 ? 117.945 102.495 74.439  1.00 87.89  ? 589 ARG A N   1 
ATOM   4102 C  CA  . ARG A 1 589 ? 118.071 103.567 75.415  1.00 85.90  ? 589 ARG A CA  1 
ATOM   4103 C  C   . ARG A 1 589 ? 117.695 103.129 76.822  1.00 82.14  ? 589 ARG A C   1 
ATOM   4104 O  O   . ARG A 1 589 ? 118.155 103.745 77.789  1.00 87.07  ? 589 ARG A O   1 
ATOM   4105 C  CB  . ARG A 1 589 ? 117.203 104.761 75.007  1.00 87.86  ? 589 ARG A CB  1 
ATOM   4106 C  CG  . ARG A 1 589 ? 117.653 105.444 73.731  1.00 88.21  ? 589 ARG A CG  1 
ATOM   4107 C  CD  . ARG A 1 589 ? 116.549 106.310 73.151  1.00 88.07  ? 589 ARG A CD  1 
ATOM   4108 N  NE  . ARG A 1 589 ? 116.550 107.650 73.724  1.00 89.85  ? 589 ARG A NE  1 
ATOM   4109 C  CZ  . ARG A 1 589 ? 116.524 108.766 73.009  1.00 91.92  ? 589 ARG A CZ  1 
ATOM   4110 N  NH1 . ARG A 1 589 ? 116.498 108.740 71.687  1.00 90.78  ? 589 ARG A NH1 1 
ATOM   4111 N  NH2 . ARG A 1 589 ? 116.525 109.939 73.637  1.00 92.33  ? 589 ARG A NH2 1 
ATOM   4112 N  N   . LEU A 1 590 ? 116.871 102.092 76.959  1.00 76.25  ? 590 LEU A N   1 
ATOM   4113 C  CA  . LEU A 1 590 ? 116.533 101.558 78.271  1.00 80.63  ? 590 LEU A CA  1 
ATOM   4114 C  C   . LEU A 1 590 ? 117.631 100.683 78.858  1.00 80.09  ? 590 LEU A C   1 
ATOM   4115 O  O   . LEU A 1 590 ? 117.615 100.421 80.065  1.00 80.57  ? 590 LEU A O   1 
ATOM   4116 C  CB  . LEU A 1 590 ? 115.233 100.752 78.197  1.00 79.34  ? 590 LEU A CB  1 
ATOM   4117 C  CG  . LEU A 1 590 ? 113.956 101.481 78.617  1.00 75.70  ? 590 LEU A CG  1 
ATOM   4118 C  CD1 . LEU A 1 590 ? 112.738 100.613 78.354  1.00 78.71  ? 590 LEU A CD1 1 
ATOM   4119 C  CD2 . LEU A 1 590 ? 114.027 101.883 80.079  1.00 75.71  ? 590 LEU A CD2 1 
ATOM   4120 N  N   . LYS A 1 591 ? 118.579 100.229 78.040  1.00 77.24  ? 591 LYS A N   1 
ATOM   4121 C  CA  . LYS A 1 591 ? 119.678 99.408  78.530  1.00 76.66  ? 591 LYS A CA  1 
ATOM   4122 C  C   . LYS A 1 591 ? 120.902 100.230 78.905  1.00 76.09  ? 591 LYS A C   1 
ATOM   4123 O  O   . LYS A 1 591 ? 121.669 99.817  79.782  1.00 82.51  ? 591 LYS A O   1 
ATOM   4124 C  CB  . LYS A 1 591 ? 120.066 98.363  77.481  1.00 76.44  ? 591 LYS A CB  1 
ATOM   4125 C  CG  . LYS A 1 591 ? 119.158 97.146  77.453  1.00 79.15  ? 591 LYS A CG  1 
ATOM   4126 C  CD  . LYS A 1 591 ? 119.811 95.986  76.721  1.00 79.94  ? 591 LYS A CD  1 
ATOM   4127 C  CE  . LYS A 1 591 ? 120.257 96.393  75.326  1.00 83.14  ? 591 LYS A CE  1 
ATOM   4128 N  NZ  . LYS A 1 591 ? 121.650 95.959  75.034  1.00 78.94  ? 591 LYS A NZ  1 
ATOM   4129 N  N   . ASN A 1 592 ? 121.105 101.378 78.259  1.00 66.94  ? 592 ASN A N   1 
ATOM   4130 C  CA  . ASN A 1 592 ? 122.226 102.242 78.608  1.00 65.06  ? 592 ASN A CA  1 
ATOM   4131 C  C   . ASN A 1 592 ? 121.974 103.015 79.895  1.00 67.19  ? 592 ASN A C   1 
ATOM   4132 O  O   . ASN A 1 592 ? 122.920 103.296 80.638  1.00 69.36  ? 592 ASN A O   1 
ATOM   4133 C  CB  . ASN A 1 592 ? 122.517 103.214 77.464  1.00 67.30  ? 592 ASN A CB  1 
ATOM   4134 C  CG  . ASN A 1 592 ? 122.972 102.510 76.204  1.00 72.83  ? 592 ASN A CG  1 
ATOM   4135 O  OD1 . ASN A 1 592 ? 122.887 101.288 76.097  1.00 75.30  ? 592 ASN A OD1 1 
ATOM   4136 N  ND2 . ASN A 1 592 ? 123.456 103.281 75.239  1.00 72.87  ? 592 ASN A ND2 1 
ATOM   4137 N  N   . ALA A 1 593 ? 120.719 103.372 80.173  1.00 68.36  ? 593 ALA A N   1 
ATOM   4138 C  CA  . ALA A 1 593 ? 120.401 104.138 81.370  1.00 64.77  ? 593 ALA A CA  1 
ATOM   4139 C  C   . ALA A 1 593 ? 120.299 103.274 82.620  1.00 66.14  ? 593 ALA A C   1 
ATOM   4140 O  O   . ALA A 1 593 ? 120.311 103.816 83.730  1.00 69.91  ? 593 ALA A O   1 
ATOM   4141 C  CB  . ALA A 1 593 ? 119.094 104.907 81.170  1.00 61.18  ? 593 ALA A CB  1 
ATOM   4142 N  N   . THR A 1 594 ? 120.196 101.953 82.472  1.00 60.12  ? 594 THR A N   1 
ATOM   4143 C  CA  . THR A 1 594 ? 120.130 101.049 83.612  1.00 62.54  ? 594 THR A CA  1 
ATOM   4144 C  C   . THR A 1 594 ? 121.455 100.359 83.906  1.00 64.29  ? 594 THR A C   1 
ATOM   4145 O  O   . THR A 1 594 ? 121.585 99.723  84.956  1.00 64.55  ? 594 THR A O   1 
ATOM   4146 C  CB  . THR A 1 594 ? 119.045 99.986  83.389  1.00 61.78  ? 594 THR A CB  1 
ATOM   4147 O  OG1 . THR A 1 594 ? 119.213 99.392  82.096  1.00 64.09  ? 594 THR A OG1 1 
ATOM   4148 C  CG2 . THR A 1 594 ? 117.664 100.610 83.475  1.00 55.03  ? 594 THR A CG2 1 
ATOM   4149 N  N   . LYS A 1 595 ? 122.429 100.465 83.008  1.00 61.51  ? 595 LYS A N   1 
ATOM   4150 C  CA  . LYS A 1 595 ? 123.739 99.881  83.236  1.00 58.97  ? 595 LYS A CA  1 
ATOM   4151 C  C   . LYS A 1 595 ? 124.493 100.671 84.308  1.00 59.17  ? 595 LYS A C   1 
ATOM   4152 O  O   . LYS A 1 595 ? 124.413 101.901 84.353  1.00 63.17  ? 595 LYS A O   1 
ATOM   4153 C  CB  . LYS A 1 595 ? 124.530 99.864  81.929  1.00 57.17  ? 595 LYS A CB  1 
ATOM   4154 C  CG  . LYS A 1 595 ? 126.009 99.555  82.060  1.00 62.99  ? 595 LYS A CG  1 
ATOM   4155 C  CD  . LYS A 1 595 ? 126.682 99.450  80.698  1.00 64.96  ? 595 LYS A CD  1 
ATOM   4156 C  CE  . LYS A 1 595 ? 126.005 100.333 79.662  1.00 63.80  ? 595 LYS A CE  1 
ATOM   4157 N  NZ  . LYS A 1 595 ? 126.475 101.742 79.747  1.00 69.81  ? 595 LYS A NZ  1 
ATOM   4158 N  N   . PRO A 1 596 ? 125.221 99.987  85.190  1.00 55.09  ? 596 PRO A N   1 
ATOM   4159 C  CA  . PRO A 1 596 ? 125.983 100.693 86.225  1.00 51.98  ? 596 PRO A CA  1 
ATOM   4160 C  C   . PRO A 1 596 ? 127.063 101.583 85.627  1.00 54.93  ? 596 PRO A C   1 
ATOM   4161 O  O   . PRO A 1 596 ? 127.611 101.318 84.555  1.00 57.71  ? 596 PRO A O   1 
ATOM   4162 C  CB  . PRO A 1 596 ? 126.600 99.560  87.055  1.00 43.09  ? 596 PRO A CB  1 
ATOM   4163 C  CG  . PRO A 1 596 ? 125.767 98.367  86.756  1.00 51.53  ? 596 PRO A CG  1 
ATOM   4164 C  CD  . PRO A 1 596 ? 125.320 98.526  85.339  1.00 56.40  ? 596 PRO A CD  1 
ATOM   4165 N  N   . SER A 1 597 ? 127.365 102.659 86.348  1.00 52.02  ? 597 SER A N   1 
ATOM   4166 C  CA  . SER A 1 597 ? 128.347 103.629 85.891  1.00 55.45  ? 597 SER A CA  1 
ATOM   4167 C  C   . SER A 1 597 ? 129.760 103.071 86.047  1.00 63.51  ? 597 SER A C   1 
ATOM   4168 O  O   . SER A 1 597 ? 129.971 101.940 86.494  1.00 66.19  ? 597 SER A O   1 
ATOM   4169 C  CB  . SER A 1 597 ? 128.191 104.942 86.652  1.00 56.08  ? 597 SER A CB  1 
ATOM   4170 O  OG  . SER A 1 597 ? 128.465 104.761 88.028  1.00 66.82  ? 597 SER A OG  1 
ATOM   4171 N  N   . ARG A 1 598 ? 130.746 103.883 85.670  1.00 73.44  ? 598 ARG A N   1 
ATOM   4172 C  CA  . ARG A 1 598 ? 132.141 103.465 85.702  1.00 73.36  ? 598 ARG A CA  1 
ATOM   4173 C  C   . ARG A 1 598 ? 132.753 103.519 87.095  1.00 74.16  ? 598 ARG A C   1 
ATOM   4174 O  O   . ARG A 1 598 ? 133.812 102.920 87.308  1.00 76.00  ? 598 ARG A O   1 
ATOM   4175 C  CB  . ARG A 1 598 ? 132.965 104.334 84.750  1.00 75.31  ? 598 ARG A CB  1 
ATOM   4176 C  CG  . ARG A 1 598 ? 133.607 103.571 83.605  1.00 76.80  ? 598 ARG A CG  1 
ATOM   4177 C  CD  . ARG A 1 598 ? 134.332 104.515 82.660  1.00 75.99  ? 598 ARG A CD  1 
ATOM   4178 N  NE  . ARG A 1 598 ? 133.423 105.484 82.058  1.00 84.05  ? 598 ARG A NE  1 
ATOM   4179 C  CZ  . ARG A 1 598 ? 133.532 106.799 82.194  1.00 84.98  ? 598 ARG A CZ  1 
ATOM   4180 N  NH1 . ARG A 1 598 ? 134.504 107.342 82.907  1.00 80.50  ? 598 ARG A NH1 1 
ATOM   4181 N  NH2 . ARG A 1 598 ? 132.641 107.588 81.600  1.00 80.98  ? 598 ARG A NH2 1 
ATOM   4182 N  N   . ASP A 1 599 ? 132.125 104.214 88.042  1.00 63.52  ? 599 ASP A N   1 
ATOM   4183 C  CA  . ASP A 1 599 ? 132.672 104.372 89.383  1.00 64.77  ? 599 ASP A CA  1 
ATOM   4184 C  C   . ASP A 1 599 ? 131.900 103.587 90.437  1.00 70.10  ? 599 ASP A C   1 
ATOM   4185 O  O   . ASP A 1 599 ? 132.134 103.784 91.633  1.00 77.12  ? 599 ASP A O   1 
ATOM   4186 C  CB  . ASP A 1 599 ? 132.720 105.854 89.762  1.00 60.95  ? 599 ASP A CB  1 
ATOM   4187 C  CG  . ASP A 1 599 ? 131.521 106.626 89.253  1.00 73.08  ? 599 ASP A CG  1 
ATOM   4188 O  OD1 . ASP A 1 599 ? 130.759 106.073 88.435  1.00 78.68  ? 599 ASP A OD1 1 
ATOM   4189 O  OD2 . ASP A 1 599 ? 131.340 107.789 89.671  1.00 72.26  ? 599 ASP A OD2 1 
ATOM   4190 N  N   . TRP A 1 600 ? 130.988 102.709 90.029  1.00 57.56  ? 600 TRP A N   1 
ATOM   4191 C  CA  . TRP A 1 600 ? 130.270 101.886 90.991  1.00 50.21  ? 600 TRP A CA  1 
ATOM   4192 C  C   . TRP A 1 600 ? 131.197 100.832 91.585  1.00 56.11  ? 600 TRP A C   1 
ATOM   4193 O  O   . TRP A 1 600 ? 131.984 100.202 90.874  1.00 65.03  ? 600 TRP A O   1 
ATOM   4194 C  CB  . TRP A 1 600 ? 129.067 101.214 90.331  1.00 45.99  ? 600 TRP A CB  1 
ATOM   4195 C  CG  . TRP A 1 600 ? 128.504 100.079 91.134  1.00 53.13  ? 600 TRP A CG  1 
ATOM   4196 C  CD1 . TRP A 1 600 ? 128.504 98.758  90.797  1.00 52.88  ? 600 TRP A CD1 1 
ATOM   4197 C  CD2 . TRP A 1 600 ? 127.863 100.166 92.412  1.00 52.24  ? 600 TRP A CD2 1 
ATOM   4198 N  NE1 . TRP A 1 600 ? 127.903 98.018  91.783  1.00 49.90  ? 600 TRP A NE1 1 
ATOM   4199 C  CE2 . TRP A 1 600 ? 127.500 98.859  92.786  1.00 45.87  ? 600 TRP A CE2 1 
ATOM   4200 C  CE3 . TRP A 1 600 ? 127.559 101.223 93.274  1.00 51.63  ? 600 TRP A CE3 1 
ATOM   4201 C  CZ2 . TRP A 1 600 ? 126.850 98.581  93.984  1.00 42.90  ? 600 TRP A CZ2 1 
ATOM   4202 C  CZ3 . TRP A 1 600 ? 126.914 100.944 94.461  1.00 48.61  ? 600 TRP A CZ3 1 
ATOM   4203 C  CH2 . TRP A 1 600 ? 126.567 99.634  94.806  1.00 45.78  ? 600 TRP A CH2 1 
ATOM   4204 N  N   . GLY A 1 601 ? 131.101 100.644 92.898  1.00 49.28  ? 601 GLY A N   1 
ATOM   4205 C  CA  . GLY A 1 601 ? 131.899 99.656  93.582  1.00 50.08  ? 601 GLY A CA  1 
ATOM   4206 C  C   . GLY A 1 601 ? 132.537 100.192 94.847  1.00 53.76  ? 601 GLY A C   1 
ATOM   4207 O  O   . GLY A 1 601 ? 132.170 101.256 95.353  1.00 57.26  ? 601 GLY A O   1 
ATOM   4208 N  N   . PRO A 1 602 ? 133.499 99.447  95.392  1.00 52.74  ? 602 PRO A N   1 
ATOM   4209 C  CA  . PRO A 1 602 ? 134.188 99.900  96.605  1.00 53.86  ? 602 PRO A CA  1 
ATOM   4210 C  C   . PRO A 1 602 ? 134.955 101.194 96.374  1.00 59.22  ? 602 PRO A C   1 
ATOM   4211 O  O   . PRO A 1 602 ? 135.494 101.441 95.294  1.00 58.55  ? 602 PRO A O   1 
ATOM   4212 C  CB  . PRO A 1 602 ? 135.136 98.739  96.926  1.00 46.85  ? 602 PRO A CB  1 
ATOM   4213 C  CG  . PRO A 1 602 ? 134.525 97.559  96.249  1.00 46.67  ? 602 PRO A CG  1 
ATOM   4214 C  CD  . PRO A 1 602 ? 133.928 98.099  94.990  1.00 48.06  ? 602 PRO A CD  1 
ATOM   4215 N  N   . ALA A 1 603 ? 134.995 102.028 97.416  1.00 53.69  ? 603 ALA A N   1 
ATOM   4216 C  CA  . ALA A 1 603 ? 135.671 103.317 97.308  1.00 43.54  ? 603 ALA A CA  1 
ATOM   4217 C  C   . ALA A 1 603 ? 137.187 103.162 97.336  1.00 48.35  ? 603 ALA A C   1 
ATOM   4218 O  O   . ALA A 1 603 ? 137.895 103.804 96.552  1.00 59.11  ? 603 ALA A O   1 
ATOM   4219 C  CB  . ALA A 1 603 ? 135.207 104.247 98.427  1.00 47.77  ? 603 ALA A CB  1 
ATOM   4220 N  N   . LEU A 1 604 ? 137.705 102.323 98.228  1.00 52.51  ? 604 LEU A N   1 
ATOM   4221 C  CA  . LEU A 1 604 ? 139.145 102.179 98.380  1.00 54.40  ? 604 LEU A CA  1 
ATOM   4222 C  C   . LEU A 1 604 ? 139.727 101.303 97.278  1.00 55.75  ? 604 LEU A C   1 
ATOM   4223 O  O   . LEU A 1 604 ? 139.058 100.421 96.735  1.00 66.83  ? 604 LEU A O   1 
ATOM   4224 C  CB  . LEU A 1 604 ? 139.488 101.589 99.748  1.00 61.81  ? 604 LEU A CB  1 
ATOM   4225 C  CG  . LEU A 1 604 ? 139.230 102.483 100.963 1.00 57.85  ? 604 LEU A CG  1 
ATOM   4226 C  CD1 . LEU A 1 604 ? 139.672 101.789 102.239 1.00 57.71  ? 604 LEU A CD1 1 
ATOM   4227 C  CD2 . LEU A 1 604 ? 139.934 103.818 100.807 1.00 56.19  ? 604 LEU A CD2 1 
ATOM   4228 N  N   . LEU A 1 605 ? 140.998 101.555 96.956  1.00 57.48  ? 605 LEU A N   1 
ATOM   4229 C  CA  . LEU A 1 605 ? 141.666 100.819 95.890  1.00 63.33  ? 605 LEU A CA  1 
ATOM   4230 C  C   . LEU A 1 605 ? 141.965 99.375  96.272  1.00 69.02  ? 605 LEU A C   1 
ATOM   4231 O  O   . LEU A 1 605 ? 141.970 98.504  95.396  1.00 70.35  ? 605 LEU A O   1 
ATOM   4232 C  CB  . LEU A 1 605 ? 142.959 101.539 95.499  1.00 66.72  ? 605 LEU A CB  1 
ATOM   4233 C  CG  . LEU A 1 605 ? 143.929 100.823 94.557  1.00 69.95  ? 605 LEU A CG  1 
ATOM   4234 C  CD1 . LEU A 1 605 ? 143.643 101.192 93.109  1.00 66.69  ? 605 LEU A CD1 1 
ATOM   4235 C  CD2 . LEU A 1 605 ? 145.367 101.149 94.922  1.00 67.64  ? 605 LEU A CD2 1 
ATOM   4236 N  N   . GLU A 1 606 ? 142.203 99.097  97.555  1.00 66.62  ? 606 GLU A N   1 
ATOM   4237 C  CA  . GLU A 1 606 ? 142.531 97.745  97.987  1.00 63.85  ? 606 GLU A CA  1 
ATOM   4238 C  C   . GLU A 1 606 ? 141.350 96.787  97.898  1.00 68.98  ? 606 GLU A C   1 
ATOM   4239 O  O   . GLU A 1 606 ? 141.560 95.570  97.849  1.00 64.65  ? 606 GLU A O   1 
ATOM   4240 C  CB  . GLU A 1 606 ? 143.064 97.768  99.421  1.00 62.93  ? 606 GLU A CB  1 
ATOM   4241 C  CG  . GLU A 1 606 ? 142.031 98.171  100.458 1.00 66.10  ? 606 GLU A CG  1 
ATOM   4242 C  CD  . GLU A 1 606 ? 142.656 98.578  101.776 1.00 74.37  ? 606 GLU A CD  1 
ATOM   4243 O  OE1 . GLU A 1 606 ? 142.928 97.686  102.607 1.00 74.69  ? 606 GLU A OE1 1 
ATOM   4244 O  OE2 . GLU A 1 606 ? 142.876 99.790  101.983 1.00 73.04  ? 606 GLU A OE2 1 
ATOM   4245 N  N   . HIS A 1 607 ? 140.121 97.299  97.882  1.00 65.49  ? 607 HIS A N   1 
ATOM   4246 C  CA  . HIS A 1 607 ? 138.929 96.469  97.799  1.00 58.04  ? 607 HIS A CA  1 
ATOM   4247 C  C   . HIS A 1 607 ? 138.411 96.313  96.376  1.00 61.34  ? 607 HIS A C   1 
ATOM   4248 O  O   . HIS A 1 607 ? 137.438 95.585  96.163  1.00 64.75  ? 607 HIS A O   1 
ATOM   4249 C  CB  . HIS A 1 607 ? 137.825 97.042  98.690  1.00 53.16  ? 607 HIS A CB  1 
ATOM   4250 C  CG  . HIS A 1 607 ? 138.212 97.158  100.130 1.00 59.35  ? 607 HIS A CG  1 
ATOM   4251 N  ND1 . HIS A 1 607 ? 138.814 96.131  100.823 1.00 62.81  ? 607 HIS A ND1 1 
ATOM   4252 C  CD2 . HIS A 1 607 ? 138.086 98.181  101.008 1.00 62.81  ? 607 HIS A CD2 1 
ATOM   4253 C  CE1 . HIS A 1 607 ? 139.041 96.515  102.066 1.00 60.75  ? 607 HIS A CE1 1 
ATOM   4254 N  NE2 . HIS A 1 607 ? 138.609 97.755  102.205 1.00 63.74  ? 607 HIS A NE2 1 
ATOM   4255 N  N   . ARG A 1 608 ? 139.034 96.973  95.402  1.00 57.42  ? 608 ARG A N   1 
ATOM   4256 C  CA  . ARG A 1 608 ? 138.621 96.863  94.003  1.00 60.37  ? 608 ARG A CA  1 
ATOM   4257 C  C   . ARG A 1 608 ? 139.346 95.682  93.356  1.00 68.64  ? 608 ARG A C   1 
ATOM   4258 O  O   . ARG A 1 608 ? 140.222 95.827  92.502  1.00 72.73  ? 608 ARG A O   1 
ATOM   4259 C  CB  . ARG A 1 608 ? 138.889 98.168  93.265  1.00 57.71  ? 608 ARG A CB  1 
ATOM   4260 C  CG  . ARG A 1 608 ? 138.146 99.361  93.844  1.00 61.92  ? 608 ARG A CG  1 
ATOM   4261 C  CD  . ARG A 1 608 ? 137.801 100.387 92.778  1.00 64.83  ? 608 ARG A CD  1 
ATOM   4262 N  NE  . ARG A 1 608 ? 136.726 99.938  91.901  1.00 72.87  ? 608 ARG A NE  1 
ATOM   4263 C  CZ  . ARG A 1 608 ? 135.610 100.618 91.677  1.00 67.17  ? 608 ARG A CZ  1 
ATOM   4264 N  NH1 . ARG A 1 608 ? 135.373 101.773 92.275  1.00 66.21  ? 608 ARG A NH1 1 
ATOM   4265 N  NH2 . ARG A 1 608 ? 134.709 100.125 90.833  1.00 60.02  ? 608 ARG A NH2 1 
ATOM   4266 N  N   . THR A 1 609 ? 138.956 94.486  93.793  1.00 75.02  ? 609 THR A N   1 
ATOM   4267 C  CA  . THR A 1 609 ? 139.534 93.243  93.307  1.00 75.55  ? 609 THR A CA  1 
ATOM   4268 C  C   . THR A 1 609 ? 138.421 92.283  92.913  1.00 78.62  ? 609 THR A C   1 
ATOM   4269 O  O   . THR A 1 609 ? 137.326 92.310  93.480  1.00 76.58  ? 609 THR A O   1 
ATOM   4270 C  CB  . THR A 1 609 ? 140.432 92.582  94.360  1.00 74.41  ? 609 THR A CB  1 
ATOM   4271 O  OG1 . THR A 1 609 ? 139.703 92.428  95.583  1.00 77.48  ? 609 THR A OG1 1 
ATOM   4272 C  CG2 . THR A 1 609 ? 141.667 93.431  94.615  1.00 75.43  ? 609 THR A CG2 1 
ATOM   4273 N  N   . GLY A 1 610 ? 138.715 91.432  91.934  1.00 78.67  ? 610 GLY A N   1 
ATOM   4274 C  CA  . GLY A 1 610 ? 137.739 90.480  91.442  1.00 75.29  ? 610 GLY A CA  1 
ATOM   4275 C  C   . GLY A 1 610 ? 137.026 90.969  90.200  1.00 73.55  ? 610 GLY A C   1 
ATOM   4276 O  O   . GLY A 1 610 ? 137.617 91.021  89.117  1.00 77.60  ? 610 GLY A O   1 
ATOM   4277 N  N   . ARG A 1 611 ? 135.753 91.325  90.341  1.00 66.72  ? 611 ARG A N   1 
ATOM   4278 C  CA  . ARG A 1 611 ? 134.976 91.882  89.243  1.00 65.93  ? 611 ARG A CA  1 
ATOM   4279 C  C   . ARG A 1 611 ? 135.121 93.393  89.124  1.00 66.76  ? 611 ARG A C   1 
ATOM   4280 O  O   . ARG A 1 611 ? 134.558 93.983  88.196  1.00 71.24  ? 611 ARG A O   1 
ATOM   4281 C  CB  . ARG A 1 611 ? 133.496 91.524  89.403  1.00 65.92  ? 611 ARG A CB  1 
ATOM   4282 C  CG  . ARG A 1 611 ? 133.243 90.167  90.034  1.00 69.22  ? 611 ARG A CG  1 
ATOM   4283 C  CD  . ARG A 1 611 ? 131.759 89.846  90.056  1.00 68.02  ? 611 ARG A CD  1 
ATOM   4284 N  NE  . ARG A 1 611 ? 131.143 90.210  91.326  1.00 70.75  ? 611 ARG A NE  1 
ATOM   4285 C  CZ  . ARG A 1 611 ? 130.282 91.206  91.483  1.00 69.55  ? 611 ARG A CZ  1 
ATOM   4286 N  NH1 . ARG A 1 611 ? 129.910 91.965  90.467  1.00 63.81  ? 611 ARG A NH1 1 
ATOM   4287 N  NH2 . ARG A 1 611 ? 129.782 91.446  92.691  1.00 65.66  ? 611 ARG A NH2 1 
ATOM   4288 N  N   . TYR A 1 612 ? 135.851 94.030  90.038  1.00 66.81  ? 612 TYR A N   1 
ATOM   4289 C  CA  . TYR A 1 612 ? 136.043 95.473  90.026  1.00 64.64  ? 612 TYR A CA  1 
ATOM   4290 C  C   . TYR A 1 612 ? 137.475 95.869  89.690  1.00 63.63  ? 612 TYR A C   1 
ATOM   4291 O  O   . TYR A 1 612 ? 137.828 97.046  89.819  1.00 60.83  ? 612 TYR A O   1 
ATOM   4292 C  CB  . TYR A 1 612 ? 135.636 96.067  91.376  1.00 58.57  ? 612 TYR A CB  1 
ATOM   4293 C  CG  . TYR A 1 612 ? 134.193 95.816  91.740  1.00 54.28  ? 612 TYR A CG  1 
ATOM   4294 C  CD1 . TYR A 1 612 ? 133.179 96.605  91.219  1.00 60.30  ? 612 TYR A CD1 1 
ATOM   4295 C  CD2 . TYR A 1 612 ? 133.844 94.787  92.600  1.00 58.43  ? 612 TYR A CD2 1 
ATOM   4296 C  CE1 . TYR A 1 612 ? 131.859 96.379  91.548  1.00 62.23  ? 612 TYR A CE1 1 
ATOM   4297 C  CE2 . TYR A 1 612 ? 132.526 94.553  92.934  1.00 61.51  ? 612 TYR A CE2 1 
ATOM   4298 C  CZ  . TYR A 1 612 ? 131.539 95.352  92.405  1.00 63.74  ? 612 TYR A CZ  1 
ATOM   4299 O  OH  . TYR A 1 612 ? 130.224 95.124  92.734  1.00 58.36  ? 612 TYR A OH  1 
ATOM   4300 N  N   . ALA A 1 613 ? 138.302 94.920  89.268  1.00 73.85  ? 613 ALA A N   1 
ATOM   4301 C  CA  . ALA A 1 613 ? 139.692 95.224  88.967  1.00 75.69  ? 613 ALA A CA  1 
ATOM   4302 C  C   . ALA A 1 613 ? 139.777 96.167  87.769  1.00 79.39  ? 613 ALA A C   1 
ATOM   4303 O  O   . ALA A 1 613 ? 139.001 96.030  86.815  1.00 81.64  ? 613 ALA A O   1 
ATOM   4304 C  CB  . ALA A 1 613 ? 140.472 93.940  88.683  1.00 73.62  ? 613 ALA A CB  1 
ATOM   4305 N  N   . PRO A 1 614 ? 140.702 97.139  87.782  1.00 89.05  ? 614 PRO A N   1 
ATOM   4306 C  CA  . PRO A 1 614 ? 140.869 98.098  86.684  1.00 86.29  ? 614 PRO A CA  1 
ATOM   4307 C  C   . PRO A 1 614 ? 141.327 97.436  85.389  1.00 86.25  ? 614 PRO A C   1 
ATOM   4308 O  O   . PRO A 1 614 ? 142.078 96.462  85.451  1.00 86.67  ? 614 PRO A O   1 
ATOM   4309 C  CB  . PRO A 1 614 ? 141.944 99.058  87.213  1.00 85.46  ? 614 PRO A CB  1 
ATOM   4310 C  CG  . PRO A 1 614 ? 141.950 98.859  88.695  1.00 83.73  ? 614 PRO A CG  1 
ATOM   4311 C  CD  . PRO A 1 614 ? 141.625 97.416  88.894  1.00 84.89  ? 614 PRO A CD  1 
HETATM 4312 N  N   . SAR B 2 .   ? 112.483 106.876 113.106 1.00 32.03  ? 701 SAR A N   1 
HETATM 4313 C  CA  . SAR B 2 .   ? 112.016 108.094 113.740 1.00 50.03  ? 701 SAR A CA  1 
HETATM 4314 C  C   . SAR B 2 .   ? 111.171 107.950 115.029 1.00 41.34  ? 701 SAR A C   1 
HETATM 4315 O  O   . SAR B 2 .   ? 110.749 106.805 115.357 1.00 47.30  ? 701 SAR A O   1 
HETATM 4316 C  CN  . SAR B 2 .   ? 113.835 106.982 112.618 1.00 28.16  ? 701 SAR A CN  1 
HETATM 4317 O  OXT . SAR B 2 .   ? 110.946 109.002 115.685 1.00 43.38  ? 701 SAR A OXT 1 
HETATM 4318 C  C1  . CLR C 3 .   ? 95.067  105.617 101.144 1.00 66.47  ? 702 CLR A C1  1 
HETATM 4319 C  C2  . CLR C 3 .   ? 94.235  106.281 102.230 1.00 71.59  ? 702 CLR A C2  1 
HETATM 4320 C  C3  . CLR C 3 .   ? 95.105  106.428 103.472 1.00 67.42  ? 702 CLR A C3  1 
HETATM 4321 C  C4  . CLR C 3 .   ? 96.261  107.373 103.154 1.00 64.38  ? 702 CLR A C4  1 
HETATM 4322 C  C5  . CLR C 3 .   ? 97.032  106.980 101.936 1.00 65.43  ? 702 CLR A C5  1 
HETATM 4323 C  C6  . CLR C 3 .   ? 98.359  107.103 101.947 1.00 64.93  ? 702 CLR A C6  1 
HETATM 4324 C  C7  . CLR C 3 .   ? 99.254  106.754 100.809 1.00 62.75  ? 702 CLR A C7  1 
HETATM 4325 C  C8  . CLR C 3 .   ? 98.481  106.438 99.532  1.00 67.17  ? 702 CLR A C8  1 
HETATM 4326 C  C9  . CLR C 3 .   ? 97.234  105.610 99.873  1.00 70.12  ? 702 CLR A C9  1 
HETATM 4327 C  C10 . CLR C 3 .   ? 96.282  106.469 100.738 1.00 67.66  ? 702 CLR A C10 1 
HETATM 4328 C  C11 . CLR C 3 .   ? 96.517  105.045 98.643  1.00 63.79  ? 702 CLR A C11 1 
HETATM 4329 C  C12 . CLR C 3 .   ? 97.387  104.572 97.477  1.00 62.33  ? 702 CLR A C12 1 
HETATM 4330 C  C13 . CLR C 3 .   ? 98.595  105.461 97.215  1.00 69.72  ? 702 CLR A C13 1 
HETATM 4331 C  C14 . CLR C 3 .   ? 99.331  105.635 98.552  1.00 68.63  ? 702 CLR A C14 1 
HETATM 4332 C  C15 . CLR C 3 .   ? 100.689 106.204 98.160  1.00 66.11  ? 702 CLR A C15 1 
HETATM 4333 C  C16 . CLR C 3 .   ? 100.942 105.695 96.731  1.00 66.15  ? 702 CLR A C16 1 
HETATM 4334 C  C17 . CLR C 3 .   ? 99.691  104.927 96.257  1.00 70.51  ? 702 CLR A C17 1 
HETATM 4335 C  C18 . CLR C 3 .   ? 98.142  106.792 96.591  1.00 65.90  ? 702 CLR A C18 1 
HETATM 4336 C  C19 . CLR C 3 .   ? 95.800  107.678 99.934  1.00 63.50  ? 702 CLR A C19 1 
HETATM 4337 C  C20 . CLR C 3 .   ? 99.364  104.947 94.746  1.00 69.08  ? 702 CLR A C20 1 
HETATM 4338 C  C21 . CLR C 3 .   ? 98.890  103.613 94.188  1.00 64.99  ? 702 CLR A C21 1 
HETATM 4339 C  C22 . CLR C 3 .   ? 100.567 105.471 93.920  1.00 65.55  ? 702 CLR A C22 1 
HETATM 4340 C  C23 . CLR C 3 .   ? 101.442 104.346 93.359  1.00 60.75  ? 702 CLR A C23 1 
HETATM 4341 C  C24 . CLR C 3 .   ? 102.227 104.833 92.141  1.00 66.14  ? 702 CLR A C24 1 
HETATM 4342 C  C25 . CLR C 3 .   ? 103.393 103.892 91.777  1.00 73.34  ? 702 CLR A C25 1 
HETATM 4343 C  C26 . CLR C 3 .   ? 104.252 104.491 90.668  1.00 64.82  ? 702 CLR A C26 1 
HETATM 4344 C  C27 . CLR C 3 .   ? 102.857 102.537 91.340  1.00 69.20  ? 702 CLR A C27 1 
HETATM 4345 O  O1  . CLR C 3 .   ? 94.334  107.028 104.468 1.00 66.50  ? 702 CLR A O1  1 
HETATM 4346 C  C1  . CLR D 3 .   ? 106.912 88.211  92.034  1.00 72.02  ? 703 CLR A C1  1 
HETATM 4347 C  C2  . CLR D 3 .   ? 107.702 86.912  92.074  1.00 75.80  ? 703 CLR A C2  1 
HETATM 4348 C  C3  . CLR D 3 .   ? 108.234 86.634  90.673  1.00 76.07  ? 703 CLR A C3  1 
HETATM 4349 C  C4  . CLR D 3 .   ? 109.226 87.730  90.305  1.00 73.90  ? 703 CLR A C4  1 
HETATM 4350 C  C5  . CLR D 3 .   ? 108.643 89.097  90.422  1.00 76.27  ? 703 CLR A C5  1 
HETATM 4351 C  C6  . CLR D 3 .   ? 108.908 89.991  89.468  1.00 74.12  ? 703 CLR A C6  1 
HETATM 4352 C  C7  . CLR D 3 .   ? 108.395 91.388  89.453  1.00 72.02  ? 703 CLR A C7  1 
HETATM 4353 C  C8  . CLR D 3 .   ? 107.725 91.768  90.772  1.00 73.43  ? 703 CLR A C8  1 
HETATM 4354 C  C9  . CLR D 3 .   ? 106.857 90.604  91.270  1.00 77.61  ? 703 CLR A C9  1 
HETATM 4355 C  C10 . CLR D 3 .   ? 107.780 89.412  91.617  1.00 75.04  ? 703 CLR A C10 1 
HETATM 4356 C  C11 . CLR D 3 .   ? 105.943 90.979  92.448  1.00 74.79  ? 703 CLR A C11 1 
HETATM 4357 C  C12 . CLR D 3 .   ? 105.350 92.396  92.464  1.00 74.73  ? 703 CLR A C12 1 
HETATM 4358 C  C13 . CLR D 3 .   ? 106.326 93.460  91.977  1.00 73.49  ? 703 CLR A C13 1 
HETATM 4359 C  C14 . CLR D 3 .   ? 106.825 92.985  90.607  1.00 76.38  ? 703 CLR A C14 1 
HETATM 4360 C  C15 . CLR D 3 .   ? 107.430 94.226  89.978  1.00 77.11  ? 703 CLR A C15 1 
HETATM 4361 C  C16 . CLR D 3 .   ? 106.534 95.367  90.461  1.00 74.08  ? 703 CLR A C16 1 
HETATM 4362 C  C17 . CLR D 3 .   ? 105.793 94.911  91.734  1.00 74.63  ? 703 CLR A C17 1 
HETATM 4363 C  C18 . CLR D 3 .   ? 107.455 93.613  92.999  1.00 71.24  ? 703 CLR A C18 1 
HETATM 4364 C  C19 . CLR D 3 .   ? 108.695 89.787  92.786  1.00 68.46  ? 703 CLR A C19 1 
HETATM 4365 C  C20 . CLR D 3 .   ? 105.838 95.893  92.923  1.00 74.73  ? 703 CLR A C20 1 
HETATM 4366 C  C21 . CLR D 3 .   ? 104.745 95.675  93.956  1.00 72.68  ? 703 CLR A C21 1 
HETATM 4367 C  C22 . CLR D 3 .   ? 105.825 97.362  92.412  1.00 75.99  ? 703 CLR A C22 1 
HETATM 4368 C  C23 . CLR D 3 .   ? 104.447 98.033  92.526  1.00 75.68  ? 703 CLR A C23 1 
HETATM 4369 C  C24 . CLR D 3 .   ? 104.510 99.312  93.369  1.00 75.91  ? 703 CLR A C24 1 
HETATM 4370 C  C25 . CLR D 3 .   ? 104.917 99.020  94.827  1.00 77.81  ? 703 CLR A C25 1 
HETATM 4371 C  C26 . CLR D 3 .   ? 103.883 99.510  95.824  1.00 80.58  ? 703 CLR A C26 1 
HETATM 4372 C  C27 . CLR D 3 .   ? 106.267 99.619  95.136  1.00 72.66  ? 703 CLR A C27 1 
HETATM 4373 O  O1  . CLR D 3 .   ? 108.935 85.430  90.709  1.00 77.17  ? 703 CLR A O1  1 
HETATM 4374 C  C1  . CLR E 3 .   ? 106.445 135.164 119.889 1.00 52.17  ? 704 CLR A C1  1 
HETATM 4375 C  C2  . CLR E 3 .   ? 105.493 135.873 120.838 1.00 53.08  ? 704 CLR A C2  1 
HETATM 4376 C  C3  . CLR E 3 .   ? 105.526 135.148 122.174 1.00 56.11  ? 704 CLR A C3  1 
HETATM 4377 C  C4  . CLR E 3 .   ? 106.930 135.266 122.764 1.00 53.33  ? 704 CLR A C4  1 
HETATM 4378 C  C5  . CLR E 3 .   ? 107.993 134.798 121.828 1.00 57.94  ? 704 CLR A C5  1 
HETATM 4379 C  C6  . CLR E 3 .   ? 108.982 134.039 122.299 1.00 55.50  ? 704 CLR A C6  1 
HETATM 4380 C  C7  . CLR E 3 .   ? 110.103 133.504 121.479 1.00 49.72  ? 704 CLR A C7  1 
HETATM 4381 C  C8  . CLR E 3 .   ? 110.170 134.145 120.093 1.00 60.29  ? 704 CLR A C8  1 
HETATM 4382 C  C9  . CLR E 3 .   ? 108.760 134.274 119.504 1.00 58.50  ? 704 CLR A C9  1 
HETATM 4383 C  C10 . CLR E 3 .   ? 107.899 135.215 120.387 1.00 57.83  ? 704 CLR A C10 1 
HETATM 4384 C  C11 . CLR E 3 .   ? 108.759 134.726 118.043 1.00 50.27  ? 704 CLR A C11 1 
HETATM 4385 C  C12 . CLR E 3 .   ? 109.847 134.154 117.131 1.00 52.18  ? 704 CLR A C12 1 
HETATM 4386 C  C13 . CLR E 3 .   ? 111.214 134.009 117.795 1.00 53.71  ? 704 CLR A C13 1 
HETATM 4387 C  C14 . CLR E 3 .   ? 110.988 133.287 119.132 1.00 59.20  ? 704 CLR A C14 1 
HETATM 4388 C  C15 . CLR E 3 .   ? 112.383 132.877 119.572 1.00 52.33  ? 704 CLR A C15 1 
HETATM 4389 C  C16 . CLR E 3 .   ? 113.133 132.601 118.265 1.00 54.28  ? 704 CLR A C16 1 
HETATM 4390 C  C17 . CLR E 3 .   ? 112.293 133.128 117.083 1.00 55.57  ? 704 CLR A C17 1 
HETATM 4391 C  C18 . CLR E 3 .   ? 111.864 135.393 117.963 1.00 50.45  ? 704 CLR A C18 1 
HETATM 4392 C  C19 . CLR E 3 .   ? 108.411 136.654 120.276 1.00 54.31  ? 704 CLR A C19 1 
HETATM 4393 C  C20 . CLR E 3 .   ? 113.103 133.726 115.906 1.00 56.38  ? 704 CLR A C20 1 
HETATM 4394 C  C21 . CLR E 3 .   ? 112.322 133.998 114.626 1.00 55.09  ? 704 CLR A C21 1 
HETATM 4395 C  C22 . CLR E 3 .   ? 114.295 132.795 115.577 1.00 52.22  ? 704 CLR A C22 1 
HETATM 4396 C  C23 . CLR E 3 .   ? 113.887 131.660 114.628 1.00 54.16  ? 704 CLR A C23 1 
HETATM 4397 C  C24 . CLR E 3 .   ? 114.916 130.530 114.628 1.00 57.12  ? 704 CLR A C24 1 
HETATM 4398 C  C25 . CLR E 3 .   ? 115.535 130.299 113.237 1.00 52.35  ? 704 CLR A C25 1 
HETATM 4399 C  C26 . CLR E 3 .   ? 116.368 129.026 113.216 1.00 48.92  ? 704 CLR A C26 1 
HETATM 4400 C  C27 . CLR E 3 .   ? 116.415 131.478 112.858 1.00 52.40  ? 704 CLR A C27 1 
HETATM 4401 O  O1  . CLR E 3 .   ? 104.646 135.798 123.036 1.00 65.60  ? 704 CLR A O1  1 
HETATM 4402 CL CL  . CL  F 4 .   ? 107.177 101.262 116.700 1.00 71.43  ? 705 CL  A CL  1 
HETATM 4403 NA NA  . NA  G 5 .   ? 111.327 104.329 116.084 1.00 57.63  ? 706 NA  A NA  1 
HETATM 4404 NA NA  . NA  H 5 .   ? 115.349 110.264 118.999 1.00 54.75  ? 707 NA  A NA  1 
HETATM 4405 O  O   . HOH I 6 .   ? 87.082  97.367  134.813 1.00 76.90  ? 801 HOH A O   1 
HETATM 4406 O  O   . HOH I 6 .   ? 113.766 100.329 103.218 1.00 51.06  ? 802 HOH A O   1 
HETATM 4407 O  O   . HOH I 6 .   ? 90.950  111.350 106.688 1.00 74.86  ? 803 HOH A O   1 
HETATM 4408 O  O   . HOH I 6 .   ? 119.408 98.732  90.103  1.00 66.46  ? 804 HOH A O   1 
HETATM 4409 O  O   . HOH I 6 .   ? 133.906 101.635 99.986  1.00 54.17  ? 805 HOH A O   1 
HETATM 4410 O  O   . HOH I 6 .   ? 101.433 99.297  133.398 1.00 63.84  ? 806 HOH A O   1 
HETATM 4411 O  O   . HOH I 6 .   ? 102.060 106.995 137.209 1.00 85.16  ? 807 HOH A O   1 
HETATM 4412 O  O   . HOH I 6 .   ? 91.664  121.130 133.648 1.00 67.59  ? 808 HOH A O   1 
HETATM 4413 O  O   . HOH I 6 .   ? 117.167 108.408 121.842 1.00 79.50  ? 809 HOH A O   1 
HETATM 4414 O  O   . HOH I 6 .   ? 98.986  105.923 108.800 1.00 56.21  ? 810 HOH A O   1 
HETATM 4415 O  O   . HOH I 6 .   ? 92.798  108.148 107.732 1.00 78.67  ? 811 HOH A O   1 
HETATM 4416 O  O   . HOH I 6 .   ? 126.253 95.411  98.828  1.00 71.27  ? 812 HOH A O   1 
HETATM 4417 O  O   . HOH I 6 .   ? 110.359 95.090  98.653  1.00 66.92  ? 813 HOH A O   1 
HETATM 4418 O  O   . HOH I 6 .   ? 97.248  102.850 104.550 1.00 63.08  ? 814 HOH A O   1 
# 
