data_9J4X
# 
_entry.id   9J4X 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9J4X         pdb_00009j4x 10.2210/pdb9j4x/pdb 
WWPDB D_1300050203 ?            ?                   
EMDB  EMD-61138    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2024-12-04 
2 'Structure model' 1 1 2025-01-15 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' 'Data collection'     
2 2 'Structure model' 'Database references' 
3 2 'Structure model' 'Structure summary'   
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' audit_author    
2 2 'Structure model' citation        
3 2 'Structure model' citation_author 
4 2 'Structure model' em_admin        
5 2 'Structure model' em_author_list  
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  2 'Structure model' '_audit_author.name'                
2  2 'Structure model' '_citation.country'                 
3  2 'Structure model' '_citation.journal_abbrev'          
4  2 'Structure model' '_citation.journal_id_CSD'          
5  2 'Structure model' '_citation.journal_id_ISSN'         
6  2 'Structure model' '_citation.journal_volume'          
7  2 'Structure model' '_citation.page_first'              
8  2 'Structure model' '_citation.page_last'               
9  2 'Structure model' '_citation.pdbx_database_id_DOI'    
10 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
11 2 'Structure model' '_citation.title'                   
12 2 'Structure model' '_citation.year'                    
13 2 'Structure model' '_em_admin.last_update'             
14 2 'Structure model' '_em_author_list.author'            
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9J4X 
_pdbx_database_status.recvd_initial_deposition_date   2024-08-10 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'CryoEM structure of human XPR1 in apo state' 
_pdbx_database_related.db_id          EMD-61138 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              liuzhu@mail.hzau.edu.cn 
_pdbx_contact_author.name_first         Zhu 
_pdbx_contact_author.name_last          Liu 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-4073-7237 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Zhang, W.H.' 1 ? 
'Chen, Y.K.'  2 ? 
'Guan, Z.Y.'  3 ? 
'Liu, Z.'     4 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Nat Commun' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2041-1723 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            16 
_citation.language                  ? 
_citation.page_first                18 
_citation.page_last                 18 
_citation.title                     'Structural insights into the mechanism of phosphate recognition and transport by XPR1.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41467-024-55471-9 
_citation.pdbx_database_id_PubMed   39747008 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Zhang, W.' 1  ?                   
primary 'Chen, Y.'  2  0000-0002-0344-880X 
primary 'Guan, Z.'  3  0009-0000-5527-543X 
primary 'Wang, Y.'  4  0000-0001-9156-0377 
primary 'Tang, M.'  5  ?                   
primary 'Du, Z.'    6  ?                   
primary 'Zhang, J.' 7  ?                   
primary 'Cheng, M.' 8  ?                   
primary 'Zuo, J.'   9  ?                   
primary 'Liu, Y.'   10 ?                   
primary 'Wang, Q.'  11 0000-0002-7048-638X 
primary 'Liu, Y.'   12 ?                   
primary 'Zhang, D.' 13 0000-0002-5299-0718 
primary 'Yin, P.'   14 0000-0001-8001-221X 
primary 'Ma, L.'    15 0000-0001-7694-7514 
primary 'Liu, Z.'   16 0000-0003-4073-7237 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Solute carrier family 53 member 1'    84595.844 2 ? ? ? ? 
2 non-polymer syn 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE 790.145   4 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        
;Phosphate exporter SLC53A1,Protein SYG1 homolog,Xenotropic and polytropic murine leukemia virus receptor X3,X-receptor,Xenotropic and polytropic retrovirus receptor 1
;
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MKFAEHLSAHITPEWRKQYIQYEAFKDMLYSAQDQAPSVEVTDEDTVKRYFAKFEEKFFQTCEKELAKINTFYSEKLAEA
QRRFATLQNELQSSLDAQKESTGVTTLRQRRKPVFHLSHEERVQHRNIKDLKLAFSEFYLSLILLQNYQNLNFTGFRKIL
KKHDKILETSRGADWRVAHVEVAPFYTCKKINQLISETEAVVTNELEDGDRQKAMKRLRVPPLGAAQPAPAWTTFRVGLF
CGIFIVLNITLVLAAVFKLETDRSIWPLIRIYRGGFLLIEFLFLLGINTYGWRQAGVNHVLIFELNPRSNLSHQHLFEIA
GFLGILWCLSLLACFFAPISVIPTYVYPLALYGFMVFFLINPTKTFYYKSRFWLLKLLFRVFTAPFHKVGFADFWLADQL
NSLSVILMDLEYMICFYSLELKWDESKGLLPNNSEESGICHKYTYGVRAIVQCIPAWLRFIQCLRRYRDTKRAFPHLVNA
GKYSTTFFMVTFAALYSTHKERGHSDTMVFFYLWIVFYIISSCYTLIWDLKMDWGLFDKNAGENTFLREEIVYPQKAYYY
CAIIEDVILRFAWTIQISITSTTLLPHSGDIIATVFAPLEVFRRFVWNFFRLENEHLNNCGEFRAVRDISVAPLNADDQT
LLEQMMDQDDGVRNRQKNRSWKYNQSISLRRPRLASQSKARDTKVLIEDTDDEANTLEDYKDHDGDYKDHDIDYKDDDDK
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MKFAEHLSAHITPEWRKQYIQYEAFKDMLYSAQDQAPSVEVTDEDTVKRYFAKFEEKFFQTCEKELAKINTFYSEKLAEA
QRRFATLQNELQSSLDAQKESTGVTTLRQRRKPVFHLSHEERVQHRNIKDLKLAFSEFYLSLILLQNYQNLNFTGFRKIL
KKHDKILETSRGADWRVAHVEVAPFYTCKKINQLISETEAVVTNELEDGDRQKAMKRLRVPPLGAAQPAPAWTTFRVGLF
CGIFIVLNITLVLAAVFKLETDRSIWPLIRIYRGGFLLIEFLFLLGINTYGWRQAGVNHVLIFELNPRSNLSHQHLFEIA
GFLGILWCLSLLACFFAPISVIPTYVYPLALYGFMVFFLINPTKTFYYKSRFWLLKLLFRVFTAPFHKVGFADFWLADQL
NSLSVILMDLEYMICFYSLELKWDESKGLLPNNSEESGICHKYTYGVRAIVQCIPAWLRFIQCLRRYRDTKRAFPHLVNA
GKYSTTFFMVTFAALYSTHKERGHSDTMVFFYLWIVFYIISSCYTLIWDLKMDWGLFDKNAGENTFLREEIVYPQKAYYY
CAIIEDVILRFAWTIQISITSTTLLPHSGDIIATVFAPLEVFRRFVWNFFRLENEHLNNCGEFRAVRDISVAPLNADDQT
LLEQMMDQDDGVRNRQKNRSWKYNQSISLRRPRLASQSKARDTKVLIEDTDDEANTLEDYKDHDGDYKDHDIDYKDDDDK
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE 
_pdbx_entity_nonpoly.comp_id     PC1 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   LYS n 
1 3   PHE n 
1 4   ALA n 
1 5   GLU n 
1 6   HIS n 
1 7   LEU n 
1 8   SER n 
1 9   ALA n 
1 10  HIS n 
1 11  ILE n 
1 12  THR n 
1 13  PRO n 
1 14  GLU n 
1 15  TRP n 
1 16  ARG n 
1 17  LYS n 
1 18  GLN n 
1 19  TYR n 
1 20  ILE n 
1 21  GLN n 
1 22  TYR n 
1 23  GLU n 
1 24  ALA n 
1 25  PHE n 
1 26  LYS n 
1 27  ASP n 
1 28  MET n 
1 29  LEU n 
1 30  TYR n 
1 31  SER n 
1 32  ALA n 
1 33  GLN n 
1 34  ASP n 
1 35  GLN n 
1 36  ALA n 
1 37  PRO n 
1 38  SER n 
1 39  VAL n 
1 40  GLU n 
1 41  VAL n 
1 42  THR n 
1 43  ASP n 
1 44  GLU n 
1 45  ASP n 
1 46  THR n 
1 47  VAL n 
1 48  LYS n 
1 49  ARG n 
1 50  TYR n 
1 51  PHE n 
1 52  ALA n 
1 53  LYS n 
1 54  PHE n 
1 55  GLU n 
1 56  GLU n 
1 57  LYS n 
1 58  PHE n 
1 59  PHE n 
1 60  GLN n 
1 61  THR n 
1 62  CYS n 
1 63  GLU n 
1 64  LYS n 
1 65  GLU n 
1 66  LEU n 
1 67  ALA n 
1 68  LYS n 
1 69  ILE n 
1 70  ASN n 
1 71  THR n 
1 72  PHE n 
1 73  TYR n 
1 74  SER n 
1 75  GLU n 
1 76  LYS n 
1 77  LEU n 
1 78  ALA n 
1 79  GLU n 
1 80  ALA n 
1 81  GLN n 
1 82  ARG n 
1 83  ARG n 
1 84  PHE n 
1 85  ALA n 
1 86  THR n 
1 87  LEU n 
1 88  GLN n 
1 89  ASN n 
1 90  GLU n 
1 91  LEU n 
1 92  GLN n 
1 93  SER n 
1 94  SER n 
1 95  LEU n 
1 96  ASP n 
1 97  ALA n 
1 98  GLN n 
1 99  LYS n 
1 100 GLU n 
1 101 SER n 
1 102 THR n 
1 103 GLY n 
1 104 VAL n 
1 105 THR n 
1 106 THR n 
1 107 LEU n 
1 108 ARG n 
1 109 GLN n 
1 110 ARG n 
1 111 ARG n 
1 112 LYS n 
1 113 PRO n 
1 114 VAL n 
1 115 PHE n 
1 116 HIS n 
1 117 LEU n 
1 118 SER n 
1 119 HIS n 
1 120 GLU n 
1 121 GLU n 
1 122 ARG n 
1 123 VAL n 
1 124 GLN n 
1 125 HIS n 
1 126 ARG n 
1 127 ASN n 
1 128 ILE n 
1 129 LYS n 
1 130 ASP n 
1 131 LEU n 
1 132 LYS n 
1 133 LEU n 
1 134 ALA n 
1 135 PHE n 
1 136 SER n 
1 137 GLU n 
1 138 PHE n 
1 139 TYR n 
1 140 LEU n 
1 141 SER n 
1 142 LEU n 
1 143 ILE n 
1 144 LEU n 
1 145 LEU n 
1 146 GLN n 
1 147 ASN n 
1 148 TYR n 
1 149 GLN n 
1 150 ASN n 
1 151 LEU n 
1 152 ASN n 
1 153 PHE n 
1 154 THR n 
1 155 GLY n 
1 156 PHE n 
1 157 ARG n 
1 158 LYS n 
1 159 ILE n 
1 160 LEU n 
1 161 LYS n 
1 162 LYS n 
1 163 HIS n 
1 164 ASP n 
1 165 LYS n 
1 166 ILE n 
1 167 LEU n 
1 168 GLU n 
1 169 THR n 
1 170 SER n 
1 171 ARG n 
1 172 GLY n 
1 173 ALA n 
1 174 ASP n 
1 175 TRP n 
1 176 ARG n 
1 177 VAL n 
1 178 ALA n 
1 179 HIS n 
1 180 VAL n 
1 181 GLU n 
1 182 VAL n 
1 183 ALA n 
1 184 PRO n 
1 185 PHE n 
1 186 TYR n 
1 187 THR n 
1 188 CYS n 
1 189 LYS n 
1 190 LYS n 
1 191 ILE n 
1 192 ASN n 
1 193 GLN n 
1 194 LEU n 
1 195 ILE n 
1 196 SER n 
1 197 GLU n 
1 198 THR n 
1 199 GLU n 
1 200 ALA n 
1 201 VAL n 
1 202 VAL n 
1 203 THR n 
1 204 ASN n 
1 205 GLU n 
1 206 LEU n 
1 207 GLU n 
1 208 ASP n 
1 209 GLY n 
1 210 ASP n 
1 211 ARG n 
1 212 GLN n 
1 213 LYS n 
1 214 ALA n 
1 215 MET n 
1 216 LYS n 
1 217 ARG n 
1 218 LEU n 
1 219 ARG n 
1 220 VAL n 
1 221 PRO n 
1 222 PRO n 
1 223 LEU n 
1 224 GLY n 
1 225 ALA n 
1 226 ALA n 
1 227 GLN n 
1 228 PRO n 
1 229 ALA n 
1 230 PRO n 
1 231 ALA n 
1 232 TRP n 
1 233 THR n 
1 234 THR n 
1 235 PHE n 
1 236 ARG n 
1 237 VAL n 
1 238 GLY n 
1 239 LEU n 
1 240 PHE n 
1 241 CYS n 
1 242 GLY n 
1 243 ILE n 
1 244 PHE n 
1 245 ILE n 
1 246 VAL n 
1 247 LEU n 
1 248 ASN n 
1 249 ILE n 
1 250 THR n 
1 251 LEU n 
1 252 VAL n 
1 253 LEU n 
1 254 ALA n 
1 255 ALA n 
1 256 VAL n 
1 257 PHE n 
1 258 LYS n 
1 259 LEU n 
1 260 GLU n 
1 261 THR n 
1 262 ASP n 
1 263 ARG n 
1 264 SER n 
1 265 ILE n 
1 266 TRP n 
1 267 PRO n 
1 268 LEU n 
1 269 ILE n 
1 270 ARG n 
1 271 ILE n 
1 272 TYR n 
1 273 ARG n 
1 274 GLY n 
1 275 GLY n 
1 276 PHE n 
1 277 LEU n 
1 278 LEU n 
1 279 ILE n 
1 280 GLU n 
1 281 PHE n 
1 282 LEU n 
1 283 PHE n 
1 284 LEU n 
1 285 LEU n 
1 286 GLY n 
1 287 ILE n 
1 288 ASN n 
1 289 THR n 
1 290 TYR n 
1 291 GLY n 
1 292 TRP n 
1 293 ARG n 
1 294 GLN n 
1 295 ALA n 
1 296 GLY n 
1 297 VAL n 
1 298 ASN n 
1 299 HIS n 
1 300 VAL n 
1 301 LEU n 
1 302 ILE n 
1 303 PHE n 
1 304 GLU n 
1 305 LEU n 
1 306 ASN n 
1 307 PRO n 
1 308 ARG n 
1 309 SER n 
1 310 ASN n 
1 311 LEU n 
1 312 SER n 
1 313 HIS n 
1 314 GLN n 
1 315 HIS n 
1 316 LEU n 
1 317 PHE n 
1 318 GLU n 
1 319 ILE n 
1 320 ALA n 
1 321 GLY n 
1 322 PHE n 
1 323 LEU n 
1 324 GLY n 
1 325 ILE n 
1 326 LEU n 
1 327 TRP n 
1 328 CYS n 
1 329 LEU n 
1 330 SER n 
1 331 LEU n 
1 332 LEU n 
1 333 ALA n 
1 334 CYS n 
1 335 PHE n 
1 336 PHE n 
1 337 ALA n 
1 338 PRO n 
1 339 ILE n 
1 340 SER n 
1 341 VAL n 
1 342 ILE n 
1 343 PRO n 
1 344 THR n 
1 345 TYR n 
1 346 VAL n 
1 347 TYR n 
1 348 PRO n 
1 349 LEU n 
1 350 ALA n 
1 351 LEU n 
1 352 TYR n 
1 353 GLY n 
1 354 PHE n 
1 355 MET n 
1 356 VAL n 
1 357 PHE n 
1 358 PHE n 
1 359 LEU n 
1 360 ILE n 
1 361 ASN n 
1 362 PRO n 
1 363 THR n 
1 364 LYS n 
1 365 THR n 
1 366 PHE n 
1 367 TYR n 
1 368 TYR n 
1 369 LYS n 
1 370 SER n 
1 371 ARG n 
1 372 PHE n 
1 373 TRP n 
1 374 LEU n 
1 375 LEU n 
1 376 LYS n 
1 377 LEU n 
1 378 LEU n 
1 379 PHE n 
1 380 ARG n 
1 381 VAL n 
1 382 PHE n 
1 383 THR n 
1 384 ALA n 
1 385 PRO n 
1 386 PHE n 
1 387 HIS n 
1 388 LYS n 
1 389 VAL n 
1 390 GLY n 
1 391 PHE n 
1 392 ALA n 
1 393 ASP n 
1 394 PHE n 
1 395 TRP n 
1 396 LEU n 
1 397 ALA n 
1 398 ASP n 
1 399 GLN n 
1 400 LEU n 
1 401 ASN n 
1 402 SER n 
1 403 LEU n 
1 404 SER n 
1 405 VAL n 
1 406 ILE n 
1 407 LEU n 
1 408 MET n 
1 409 ASP n 
1 410 LEU n 
1 411 GLU n 
1 412 TYR n 
1 413 MET n 
1 414 ILE n 
1 415 CYS n 
1 416 PHE n 
1 417 TYR n 
1 418 SER n 
1 419 LEU n 
1 420 GLU n 
1 421 LEU n 
1 422 LYS n 
1 423 TRP n 
1 424 ASP n 
1 425 GLU n 
1 426 SER n 
1 427 LYS n 
1 428 GLY n 
1 429 LEU n 
1 430 LEU n 
1 431 PRO n 
1 432 ASN n 
1 433 ASN n 
1 434 SER n 
1 435 GLU n 
1 436 GLU n 
1 437 SER n 
1 438 GLY n 
1 439 ILE n 
1 440 CYS n 
1 441 HIS n 
1 442 LYS n 
1 443 TYR n 
1 444 THR n 
1 445 TYR n 
1 446 GLY n 
1 447 VAL n 
1 448 ARG n 
1 449 ALA n 
1 450 ILE n 
1 451 VAL n 
1 452 GLN n 
1 453 CYS n 
1 454 ILE n 
1 455 PRO n 
1 456 ALA n 
1 457 TRP n 
1 458 LEU n 
1 459 ARG n 
1 460 PHE n 
1 461 ILE n 
1 462 GLN n 
1 463 CYS n 
1 464 LEU n 
1 465 ARG n 
1 466 ARG n 
1 467 TYR n 
1 468 ARG n 
1 469 ASP n 
1 470 THR n 
1 471 LYS n 
1 472 ARG n 
1 473 ALA n 
1 474 PHE n 
1 475 PRO n 
1 476 HIS n 
1 477 LEU n 
1 478 VAL n 
1 479 ASN n 
1 480 ALA n 
1 481 GLY n 
1 482 LYS n 
1 483 TYR n 
1 484 SER n 
1 485 THR n 
1 486 THR n 
1 487 PHE n 
1 488 PHE n 
1 489 MET n 
1 490 VAL n 
1 491 THR n 
1 492 PHE n 
1 493 ALA n 
1 494 ALA n 
1 495 LEU n 
1 496 TYR n 
1 497 SER n 
1 498 THR n 
1 499 HIS n 
1 500 LYS n 
1 501 GLU n 
1 502 ARG n 
1 503 GLY n 
1 504 HIS n 
1 505 SER n 
1 506 ASP n 
1 507 THR n 
1 508 MET n 
1 509 VAL n 
1 510 PHE n 
1 511 PHE n 
1 512 TYR n 
1 513 LEU n 
1 514 TRP n 
1 515 ILE n 
1 516 VAL n 
1 517 PHE n 
1 518 TYR n 
1 519 ILE n 
1 520 ILE n 
1 521 SER n 
1 522 SER n 
1 523 CYS n 
1 524 TYR n 
1 525 THR n 
1 526 LEU n 
1 527 ILE n 
1 528 TRP n 
1 529 ASP n 
1 530 LEU n 
1 531 LYS n 
1 532 MET n 
1 533 ASP n 
1 534 TRP n 
1 535 GLY n 
1 536 LEU n 
1 537 PHE n 
1 538 ASP n 
1 539 LYS n 
1 540 ASN n 
1 541 ALA n 
1 542 GLY n 
1 543 GLU n 
1 544 ASN n 
1 545 THR n 
1 546 PHE n 
1 547 LEU n 
1 548 ARG n 
1 549 GLU n 
1 550 GLU n 
1 551 ILE n 
1 552 VAL n 
1 553 TYR n 
1 554 PRO n 
1 555 GLN n 
1 556 LYS n 
1 557 ALA n 
1 558 TYR n 
1 559 TYR n 
1 560 TYR n 
1 561 CYS n 
1 562 ALA n 
1 563 ILE n 
1 564 ILE n 
1 565 GLU n 
1 566 ASP n 
1 567 VAL n 
1 568 ILE n 
1 569 LEU n 
1 570 ARG n 
1 571 PHE n 
1 572 ALA n 
1 573 TRP n 
1 574 THR n 
1 575 ILE n 
1 576 GLN n 
1 577 ILE n 
1 578 SER n 
1 579 ILE n 
1 580 THR n 
1 581 SER n 
1 582 THR n 
1 583 THR n 
1 584 LEU n 
1 585 LEU n 
1 586 PRO n 
1 587 HIS n 
1 588 SER n 
1 589 GLY n 
1 590 ASP n 
1 591 ILE n 
1 592 ILE n 
1 593 ALA n 
1 594 THR n 
1 595 VAL n 
1 596 PHE n 
1 597 ALA n 
1 598 PRO n 
1 599 LEU n 
1 600 GLU n 
1 601 VAL n 
1 602 PHE n 
1 603 ARG n 
1 604 ARG n 
1 605 PHE n 
1 606 VAL n 
1 607 TRP n 
1 608 ASN n 
1 609 PHE n 
1 610 PHE n 
1 611 ARG n 
1 612 LEU n 
1 613 GLU n 
1 614 ASN n 
1 615 GLU n 
1 616 HIS n 
1 617 LEU n 
1 618 ASN n 
1 619 ASN n 
1 620 CYS n 
1 621 GLY n 
1 622 GLU n 
1 623 PHE n 
1 624 ARG n 
1 625 ALA n 
1 626 VAL n 
1 627 ARG n 
1 628 ASP n 
1 629 ILE n 
1 630 SER n 
1 631 VAL n 
1 632 ALA n 
1 633 PRO n 
1 634 LEU n 
1 635 ASN n 
1 636 ALA n 
1 637 ASP n 
1 638 ASP n 
1 639 GLN n 
1 640 THR n 
1 641 LEU n 
1 642 LEU n 
1 643 GLU n 
1 644 GLN n 
1 645 MET n 
1 646 MET n 
1 647 ASP n 
1 648 GLN n 
1 649 ASP n 
1 650 ASP n 
1 651 GLY n 
1 652 VAL n 
1 653 ARG n 
1 654 ASN n 
1 655 ARG n 
1 656 GLN n 
1 657 LYS n 
1 658 ASN n 
1 659 ARG n 
1 660 SER n 
1 661 TRP n 
1 662 LYS n 
1 663 TYR n 
1 664 ASN n 
1 665 GLN n 
1 666 SER n 
1 667 ILE n 
1 668 SER n 
1 669 LEU n 
1 670 ARG n 
1 671 ARG n 
1 672 PRO n 
1 673 ARG n 
1 674 LEU n 
1 675 ALA n 
1 676 SER n 
1 677 GLN n 
1 678 SER n 
1 679 LYS n 
1 680 ALA n 
1 681 ARG n 
1 682 ASP n 
1 683 THR n 
1 684 LYS n 
1 685 VAL n 
1 686 LEU n 
1 687 ILE n 
1 688 GLU n 
1 689 ASP n 
1 690 THR n 
1 691 ASP n 
1 692 ASP n 
1 693 GLU n 
1 694 ALA n 
1 695 ASN n 
1 696 THR n 
1 697 LEU n 
1 698 GLU n 
1 699 ASP n 
1 700 TYR n 
1 701 LYS n 
1 702 ASP n 
1 703 HIS n 
1 704 ASP n 
1 705 GLY n 
1 706 ASP n 
1 707 TYR n 
1 708 LYS n 
1 709 ASP n 
1 710 HIS n 
1 711 ASP n 
1 712 ILE n 
1 713 ASP n 
1 714 TYR n 
1 715 LYS n 
1 716 ASP n 
1 717 ASP n 
1 718 ASP n 
1 719 ASP n 
1 720 LYS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   720 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'XPR1, SLC53A1, SYG1, X3' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     9606 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                ?                        'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                               ?                        'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                             ?                        'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                        ?                        'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE                               ?                        'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE                              ?                        'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                        ?                        'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                                ?                        'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                              ?                        'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE                             ?                        'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                                ?                        'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                                 ?                        'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE                             ?                        'C5 H11 N O2 S'  149.211 
PC1 non-polymer         . 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE 3-SN-PHOSPHATIDYLCHOLINE 'C44 H88 N O8 P' 790.145 
PHE 'L-peptide linking' y PHENYLALANINE                          ?                        'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE                                ?                        'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                                 ?                        'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                              ?                        'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                             ?                        'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                               ?                        'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                                 ?                        'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   LYS 2   2   ?   ?   ?   A . n 
A 1 3   PHE 3   3   ?   ?   ?   A . n 
A 1 4   ALA 4   4   ?   ?   ?   A . n 
A 1 5   GLU 5   5   ?   ?   ?   A . n 
A 1 6   HIS 6   6   ?   ?   ?   A . n 
A 1 7   LEU 7   7   ?   ?   ?   A . n 
A 1 8   SER 8   8   ?   ?   ?   A . n 
A 1 9   ALA 9   9   ?   ?   ?   A . n 
A 1 10  HIS 10  10  ?   ?   ?   A . n 
A 1 11  ILE 11  11  ?   ?   ?   A . n 
A 1 12  THR 12  12  ?   ?   ?   A . n 
A 1 13  PRO 13  13  ?   ?   ?   A . n 
A 1 14  GLU 14  14  ?   ?   ?   A . n 
A 1 15  TRP 15  15  ?   ?   ?   A . n 
A 1 16  ARG 16  16  ?   ?   ?   A . n 
A 1 17  LYS 17  17  ?   ?   ?   A . n 
A 1 18  GLN 18  18  ?   ?   ?   A . n 
A 1 19  TYR 19  19  ?   ?   ?   A . n 
A 1 20  ILE 20  20  ?   ?   ?   A . n 
A 1 21  GLN 21  21  ?   ?   ?   A . n 
A 1 22  TYR 22  22  ?   ?   ?   A . n 
A 1 23  GLU 23  23  ?   ?   ?   A . n 
A 1 24  ALA 24  24  ?   ?   ?   A . n 
A 1 25  PHE 25  25  ?   ?   ?   A . n 
A 1 26  LYS 26  26  ?   ?   ?   A . n 
A 1 27  ASP 27  27  ?   ?   ?   A . n 
A 1 28  MET 28  28  ?   ?   ?   A . n 
A 1 29  LEU 29  29  ?   ?   ?   A . n 
A 1 30  TYR 30  30  ?   ?   ?   A . n 
A 1 31  SER 31  31  ?   ?   ?   A . n 
A 1 32  ALA 32  32  ?   ?   ?   A . n 
A 1 33  GLN 33  33  ?   ?   ?   A . n 
A 1 34  ASP 34  34  ?   ?   ?   A . n 
A 1 35  GLN 35  35  ?   ?   ?   A . n 
A 1 36  ALA 36  36  ?   ?   ?   A . n 
A 1 37  PRO 37  37  ?   ?   ?   A . n 
A 1 38  SER 38  38  ?   ?   ?   A . n 
A 1 39  VAL 39  39  ?   ?   ?   A . n 
A 1 40  GLU 40  40  ?   ?   ?   A . n 
A 1 41  VAL 41  41  ?   ?   ?   A . n 
A 1 42  THR 42  42  ?   ?   ?   A . n 
A 1 43  ASP 43  43  ?   ?   ?   A . n 
A 1 44  GLU 44  44  ?   ?   ?   A . n 
A 1 45  ASP 45  45  ?   ?   ?   A . n 
A 1 46  THR 46  46  ?   ?   ?   A . n 
A 1 47  VAL 47  47  ?   ?   ?   A . n 
A 1 48  LYS 48  48  ?   ?   ?   A . n 
A 1 49  ARG 49  49  ?   ?   ?   A . n 
A 1 50  TYR 50  50  ?   ?   ?   A . n 
A 1 51  PHE 51  51  ?   ?   ?   A . n 
A 1 52  ALA 52  52  ?   ?   ?   A . n 
A 1 53  LYS 53  53  ?   ?   ?   A . n 
A 1 54  PHE 54  54  ?   ?   ?   A . n 
A 1 55  GLU 55  55  ?   ?   ?   A . n 
A 1 56  GLU 56  56  ?   ?   ?   A . n 
A 1 57  LYS 57  57  ?   ?   ?   A . n 
A 1 58  PHE 58  58  ?   ?   ?   A . n 
A 1 59  PHE 59  59  ?   ?   ?   A . n 
A 1 60  GLN 60  60  ?   ?   ?   A . n 
A 1 61  THR 61  61  ?   ?   ?   A . n 
A 1 62  CYS 62  62  ?   ?   ?   A . n 
A 1 63  GLU 63  63  ?   ?   ?   A . n 
A 1 64  LYS 64  64  ?   ?   ?   A . n 
A 1 65  GLU 65  65  ?   ?   ?   A . n 
A 1 66  LEU 66  66  ?   ?   ?   A . n 
A 1 67  ALA 67  67  ?   ?   ?   A . n 
A 1 68  LYS 68  68  ?   ?   ?   A . n 
A 1 69  ILE 69  69  ?   ?   ?   A . n 
A 1 70  ASN 70  70  ?   ?   ?   A . n 
A 1 71  THR 71  71  ?   ?   ?   A . n 
A 1 72  PHE 72  72  ?   ?   ?   A . n 
A 1 73  TYR 73  73  ?   ?   ?   A . n 
A 1 74  SER 74  74  ?   ?   ?   A . n 
A 1 75  GLU 75  75  ?   ?   ?   A . n 
A 1 76  LYS 76  76  ?   ?   ?   A . n 
A 1 77  LEU 77  77  ?   ?   ?   A . n 
A 1 78  ALA 78  78  ?   ?   ?   A . n 
A 1 79  GLU 79  79  ?   ?   ?   A . n 
A 1 80  ALA 80  80  ?   ?   ?   A . n 
A 1 81  GLN 81  81  ?   ?   ?   A . n 
A 1 82  ARG 82  82  ?   ?   ?   A . n 
A 1 83  ARG 83  83  ?   ?   ?   A . n 
A 1 84  PHE 84  84  ?   ?   ?   A . n 
A 1 85  ALA 85  85  ?   ?   ?   A . n 
A 1 86  THR 86  86  ?   ?   ?   A . n 
A 1 87  LEU 87  87  ?   ?   ?   A . n 
A 1 88  GLN 88  88  ?   ?   ?   A . n 
A 1 89  ASN 89  89  ?   ?   ?   A . n 
A 1 90  GLU 90  90  ?   ?   ?   A . n 
A 1 91  LEU 91  91  ?   ?   ?   A . n 
A 1 92  GLN 92  92  ?   ?   ?   A . n 
A 1 93  SER 93  93  ?   ?   ?   A . n 
A 1 94  SER 94  94  ?   ?   ?   A . n 
A 1 95  LEU 95  95  ?   ?   ?   A . n 
A 1 96  ASP 96  96  ?   ?   ?   A . n 
A 1 97  ALA 97  97  ?   ?   ?   A . n 
A 1 98  GLN 98  98  ?   ?   ?   A . n 
A 1 99  LYS 99  99  ?   ?   ?   A . n 
A 1 100 GLU 100 100 ?   ?   ?   A . n 
A 1 101 SER 101 101 ?   ?   ?   A . n 
A 1 102 THR 102 102 ?   ?   ?   A . n 
A 1 103 GLY 103 103 ?   ?   ?   A . n 
A 1 104 VAL 104 104 ?   ?   ?   A . n 
A 1 105 THR 105 105 ?   ?   ?   A . n 
A 1 106 THR 106 106 ?   ?   ?   A . n 
A 1 107 LEU 107 107 ?   ?   ?   A . n 
A 1 108 ARG 108 108 ?   ?   ?   A . n 
A 1 109 GLN 109 109 ?   ?   ?   A . n 
A 1 110 ARG 110 110 ?   ?   ?   A . n 
A 1 111 ARG 111 111 ?   ?   ?   A . n 
A 1 112 LYS 112 112 ?   ?   ?   A . n 
A 1 113 PRO 113 113 ?   ?   ?   A . n 
A 1 114 VAL 114 114 ?   ?   ?   A . n 
A 1 115 PHE 115 115 ?   ?   ?   A . n 
A 1 116 HIS 116 116 ?   ?   ?   A . n 
A 1 117 LEU 117 117 ?   ?   ?   A . n 
A 1 118 SER 118 118 ?   ?   ?   A . n 
A 1 119 HIS 119 119 ?   ?   ?   A . n 
A 1 120 GLU 120 120 ?   ?   ?   A . n 
A 1 121 GLU 121 121 ?   ?   ?   A . n 
A 1 122 ARG 122 122 ?   ?   ?   A . n 
A 1 123 VAL 123 123 ?   ?   ?   A . n 
A 1 124 GLN 124 124 ?   ?   ?   A . n 
A 1 125 HIS 125 125 ?   ?   ?   A . n 
A 1 126 ARG 126 126 ?   ?   ?   A . n 
A 1 127 ASN 127 127 ?   ?   ?   A . n 
A 1 128 ILE 128 128 ?   ?   ?   A . n 
A 1 129 LYS 129 129 ?   ?   ?   A . n 
A 1 130 ASP 130 130 ?   ?   ?   A . n 
A 1 131 LEU 131 131 ?   ?   ?   A . n 
A 1 132 LYS 132 132 ?   ?   ?   A . n 
A 1 133 LEU 133 133 ?   ?   ?   A . n 
A 1 134 ALA 134 134 ?   ?   ?   A . n 
A 1 135 PHE 135 135 ?   ?   ?   A . n 
A 1 136 SER 136 136 ?   ?   ?   A . n 
A 1 137 GLU 137 137 ?   ?   ?   A . n 
A 1 138 PHE 138 138 ?   ?   ?   A . n 
A 1 139 TYR 139 139 ?   ?   ?   A . n 
A 1 140 LEU 140 140 ?   ?   ?   A . n 
A 1 141 SER 141 141 ?   ?   ?   A . n 
A 1 142 LEU 142 142 ?   ?   ?   A . n 
A 1 143 ILE 143 143 ?   ?   ?   A . n 
A 1 144 LEU 144 144 ?   ?   ?   A . n 
A 1 145 LEU 145 145 ?   ?   ?   A . n 
A 1 146 GLN 146 146 ?   ?   ?   A . n 
A 1 147 ASN 147 147 ?   ?   ?   A . n 
A 1 148 TYR 148 148 ?   ?   ?   A . n 
A 1 149 GLN 149 149 ?   ?   ?   A . n 
A 1 150 ASN 150 150 ?   ?   ?   A . n 
A 1 151 LEU 151 151 ?   ?   ?   A . n 
A 1 152 ASN 152 152 ?   ?   ?   A . n 
A 1 153 PHE 153 153 ?   ?   ?   A . n 
A 1 154 THR 154 154 ?   ?   ?   A . n 
A 1 155 GLY 155 155 ?   ?   ?   A . n 
A 1 156 PHE 156 156 ?   ?   ?   A . n 
A 1 157 ARG 157 157 ?   ?   ?   A . n 
A 1 158 LYS 158 158 ?   ?   ?   A . n 
A 1 159 ILE 159 159 ?   ?   ?   A . n 
A 1 160 LEU 160 160 ?   ?   ?   A . n 
A 1 161 LYS 161 161 ?   ?   ?   A . n 
A 1 162 LYS 162 162 ?   ?   ?   A . n 
A 1 163 HIS 163 163 ?   ?   ?   A . n 
A 1 164 ASP 164 164 ?   ?   ?   A . n 
A 1 165 LYS 165 165 ?   ?   ?   A . n 
A 1 166 ILE 166 166 ?   ?   ?   A . n 
A 1 167 LEU 167 167 ?   ?   ?   A . n 
A 1 168 GLU 168 168 ?   ?   ?   A . n 
A 1 169 THR 169 169 ?   ?   ?   A . n 
A 1 170 SER 170 170 ?   ?   ?   A . n 
A 1 171 ARG 171 171 ?   ?   ?   A . n 
A 1 172 GLY 172 172 ?   ?   ?   A . n 
A 1 173 ALA 173 173 ?   ?   ?   A . n 
A 1 174 ASP 174 174 ?   ?   ?   A . n 
A 1 175 TRP 175 175 ?   ?   ?   A . n 
A 1 176 ARG 176 176 ?   ?   ?   A . n 
A 1 177 VAL 177 177 ?   ?   ?   A . n 
A 1 178 ALA 178 178 ?   ?   ?   A . n 
A 1 179 HIS 179 179 ?   ?   ?   A . n 
A 1 180 VAL 180 180 ?   ?   ?   A . n 
A 1 181 GLU 181 181 ?   ?   ?   A . n 
A 1 182 VAL 182 182 ?   ?   ?   A . n 
A 1 183 ALA 183 183 ?   ?   ?   A . n 
A 1 184 PRO 184 184 ?   ?   ?   A . n 
A 1 185 PHE 185 185 ?   ?   ?   A . n 
A 1 186 TYR 186 186 ?   ?   ?   A . n 
A 1 187 THR 187 187 ?   ?   ?   A . n 
A 1 188 CYS 188 188 ?   ?   ?   A . n 
A 1 189 LYS 189 189 ?   ?   ?   A . n 
A 1 190 LYS 190 190 ?   ?   ?   A . n 
A 1 191 ILE 191 191 ?   ?   ?   A . n 
A 1 192 ASN 192 192 ?   ?   ?   A . n 
A 1 193 GLN 193 193 ?   ?   ?   A . n 
A 1 194 LEU 194 194 ?   ?   ?   A . n 
A 1 195 ILE 195 195 ?   ?   ?   A . n 
A 1 196 SER 196 196 ?   ?   ?   A . n 
A 1 197 GLU 197 197 ?   ?   ?   A . n 
A 1 198 THR 198 198 ?   ?   ?   A . n 
A 1 199 GLU 199 199 ?   ?   ?   A . n 
A 1 200 ALA 200 200 ?   ?   ?   A . n 
A 1 201 VAL 201 201 ?   ?   ?   A . n 
A 1 202 VAL 202 202 ?   ?   ?   A . n 
A 1 203 THR 203 203 ?   ?   ?   A . n 
A 1 204 ASN 204 204 ?   ?   ?   A . n 
A 1 205 GLU 205 205 ?   ?   ?   A . n 
A 1 206 LEU 206 206 ?   ?   ?   A . n 
A 1 207 GLU 207 207 ?   ?   ?   A . n 
A 1 208 ASP 208 208 ?   ?   ?   A . n 
A 1 209 GLY 209 209 ?   ?   ?   A . n 
A 1 210 ASP 210 210 ?   ?   ?   A . n 
A 1 211 ARG 211 211 ?   ?   ?   A . n 
A 1 212 GLN 212 212 ?   ?   ?   A . n 
A 1 213 LYS 213 213 ?   ?   ?   A . n 
A 1 214 ALA 214 214 ?   ?   ?   A . n 
A 1 215 MET 215 215 ?   ?   ?   A . n 
A 1 216 LYS 216 216 ?   ?   ?   A . n 
A 1 217 ARG 217 217 ?   ?   ?   A . n 
A 1 218 LEU 218 218 ?   ?   ?   A . n 
A 1 219 ARG 219 219 ?   ?   ?   A . n 
A 1 220 VAL 220 220 ?   ?   ?   A . n 
A 1 221 PRO 221 221 ?   ?   ?   A . n 
A 1 222 PRO 222 222 ?   ?   ?   A . n 
A 1 223 LEU 223 223 ?   ?   ?   A . n 
A 1 224 GLY 224 224 ?   ?   ?   A . n 
A 1 225 ALA 225 225 ?   ?   ?   A . n 
A 1 226 ALA 226 226 ?   ?   ?   A . n 
A 1 227 GLN 227 227 ?   ?   ?   A . n 
A 1 228 PRO 228 228 ?   ?   ?   A . n 
A 1 229 ALA 229 229 229 ALA ALA A . n 
A 1 230 PRO 230 230 230 PRO PRO A . n 
A 1 231 ALA 231 231 231 ALA ALA A . n 
A 1 232 TRP 232 232 232 TRP TRP A . n 
A 1 233 THR 233 233 233 THR THR A . n 
A 1 234 THR 234 234 234 THR THR A . n 
A 1 235 PHE 235 235 235 PHE PHE A . n 
A 1 236 ARG 236 236 236 ARG ARG A . n 
A 1 237 VAL 237 237 237 VAL VAL A . n 
A 1 238 GLY 238 238 238 GLY GLY A . n 
A 1 239 LEU 239 239 239 LEU LEU A . n 
A 1 240 PHE 240 240 240 PHE PHE A . n 
A 1 241 CYS 241 241 241 CYS CYS A . n 
A 1 242 GLY 242 242 242 GLY GLY A . n 
A 1 243 ILE 243 243 243 ILE ILE A . n 
A 1 244 PHE 244 244 244 PHE PHE A . n 
A 1 245 ILE 245 245 245 ILE ILE A . n 
A 1 246 VAL 246 246 246 VAL VAL A . n 
A 1 247 LEU 247 247 247 LEU LEU A . n 
A 1 248 ASN 248 248 248 ASN ASN A . n 
A 1 249 ILE 249 249 249 ILE ILE A . n 
A 1 250 THR 250 250 250 THR THR A . n 
A 1 251 LEU 251 251 251 LEU LEU A . n 
A 1 252 VAL 252 252 252 VAL VAL A . n 
A 1 253 LEU 253 253 253 LEU LEU A . n 
A 1 254 ALA 254 254 254 ALA ALA A . n 
A 1 255 ALA 255 255 255 ALA ALA A . n 
A 1 256 VAL 256 256 256 VAL VAL A . n 
A 1 257 PHE 257 257 257 PHE PHE A . n 
A 1 258 LYS 258 258 258 LYS LYS A . n 
A 1 259 LEU 259 259 259 LEU LEU A . n 
A 1 260 GLU 260 260 260 GLU GLU A . n 
A 1 261 THR 261 261 261 THR THR A . n 
A 1 262 ASP 262 262 262 ASP ASP A . n 
A 1 263 ARG 263 263 263 ARG ARG A . n 
A 1 264 SER 264 264 264 SER SER A . n 
A 1 265 ILE 265 265 265 ILE ILE A . n 
A 1 266 TRP 266 266 266 TRP TRP A . n 
A 1 267 PRO 267 267 267 PRO PRO A . n 
A 1 268 LEU 268 268 268 LEU LEU A . n 
A 1 269 ILE 269 269 269 ILE ILE A . n 
A 1 270 ARG 270 270 270 ARG ARG A . n 
A 1 271 ILE 271 271 271 ILE ILE A . n 
A 1 272 TYR 272 272 272 TYR TYR A . n 
A 1 273 ARG 273 273 273 ARG ARG A . n 
A 1 274 GLY 274 274 274 GLY GLY A . n 
A 1 275 GLY 275 275 275 GLY GLY A . n 
A 1 276 PHE 276 276 276 PHE PHE A . n 
A 1 277 LEU 277 277 277 LEU LEU A . n 
A 1 278 LEU 278 278 278 LEU LEU A . n 
A 1 279 ILE 279 279 279 ILE ILE A . n 
A 1 280 GLU 280 280 280 GLU GLU A . n 
A 1 281 PHE 281 281 281 PHE PHE A . n 
A 1 282 LEU 282 282 282 LEU LEU A . n 
A 1 283 PHE 283 283 283 PHE PHE A . n 
A 1 284 LEU 284 284 284 LEU LEU A . n 
A 1 285 LEU 285 285 285 LEU LEU A . n 
A 1 286 GLY 286 286 286 GLY GLY A . n 
A 1 287 ILE 287 287 287 ILE ILE A . n 
A 1 288 ASN 288 288 288 ASN ASN A . n 
A 1 289 THR 289 289 289 THR THR A . n 
A 1 290 TYR 290 290 290 TYR TYR A . n 
A 1 291 GLY 291 291 291 GLY GLY A . n 
A 1 292 TRP 292 292 292 TRP TRP A . n 
A 1 293 ARG 293 293 293 ARG ARG A . n 
A 1 294 GLN 294 294 294 GLN GLN A . n 
A 1 295 ALA 295 295 295 ALA ALA A . n 
A 1 296 GLY 296 296 296 GLY GLY A . n 
A 1 297 VAL 297 297 297 VAL VAL A . n 
A 1 298 ASN 298 298 298 ASN ASN A . n 
A 1 299 HIS 299 299 299 HIS HIS A . n 
A 1 300 VAL 300 300 300 VAL VAL A . n 
A 1 301 LEU 301 301 301 LEU LEU A . n 
A 1 302 ILE 302 302 302 ILE ILE A . n 
A 1 303 PHE 303 303 303 PHE PHE A . n 
A 1 304 GLU 304 304 304 GLU GLU A . n 
A 1 305 LEU 305 305 305 LEU LEU A . n 
A 1 306 ASN 306 306 306 ASN ASN A . n 
A 1 307 PRO 307 307 307 PRO PRO A . n 
A 1 308 ARG 308 308 308 ARG ARG A . n 
A 1 309 SER 309 309 309 SER SER A . n 
A 1 310 ASN 310 310 310 ASN ASN A . n 
A 1 311 LEU 311 311 311 LEU LEU A . n 
A 1 312 SER 312 312 312 SER SER A . n 
A 1 313 HIS 313 313 313 HIS HIS A . n 
A 1 314 GLN 314 314 314 GLN GLN A . n 
A 1 315 HIS 315 315 315 HIS HIS A . n 
A 1 316 LEU 316 316 316 LEU LEU A . n 
A 1 317 PHE 317 317 317 PHE PHE A . n 
A 1 318 GLU 318 318 318 GLU GLU A . n 
A 1 319 ILE 319 319 319 ILE ILE A . n 
A 1 320 ALA 320 320 320 ALA ALA A . n 
A 1 321 GLY 321 321 321 GLY GLY A . n 
A 1 322 PHE 322 322 322 PHE PHE A . n 
A 1 323 LEU 323 323 323 LEU LEU A . n 
A 1 324 GLY 324 324 324 GLY GLY A . n 
A 1 325 ILE 325 325 325 ILE ILE A . n 
A 1 326 LEU 326 326 326 LEU LEU A . n 
A 1 327 TRP 327 327 327 TRP TRP A . n 
A 1 328 CYS 328 328 328 CYS CYS A . n 
A 1 329 LEU 329 329 329 LEU LEU A . n 
A 1 330 SER 330 330 330 SER SER A . n 
A 1 331 LEU 331 331 331 LEU LEU A . n 
A 1 332 LEU 332 332 332 LEU LEU A . n 
A 1 333 ALA 333 333 333 ALA ALA A . n 
A 1 334 CYS 334 334 334 CYS CYS A . n 
A 1 335 PHE 335 335 335 PHE PHE A . n 
A 1 336 PHE 336 336 336 PHE PHE A . n 
A 1 337 ALA 337 337 337 ALA ALA A . n 
A 1 338 PRO 338 338 338 PRO PRO A . n 
A 1 339 ILE 339 339 339 ILE ILE A . n 
A 1 340 SER 340 340 340 SER SER A . n 
A 1 341 VAL 341 341 341 VAL VAL A . n 
A 1 342 ILE 342 342 342 ILE ILE A . n 
A 1 343 PRO 343 343 343 PRO PRO A . n 
A 1 344 THR 344 344 344 THR THR A . n 
A 1 345 TYR 345 345 345 TYR TYR A . n 
A 1 346 VAL 346 346 346 VAL VAL A . n 
A 1 347 TYR 347 347 347 TYR TYR A . n 
A 1 348 PRO 348 348 348 PRO PRO A . n 
A 1 349 LEU 349 349 349 LEU LEU A . n 
A 1 350 ALA 350 350 350 ALA ALA A . n 
A 1 351 LEU 351 351 351 LEU LEU A . n 
A 1 352 TYR 352 352 352 TYR TYR A . n 
A 1 353 GLY 353 353 353 GLY GLY A . n 
A 1 354 PHE 354 354 354 PHE PHE A . n 
A 1 355 MET 355 355 355 MET MET A . n 
A 1 356 VAL 356 356 356 VAL VAL A . n 
A 1 357 PHE 357 357 357 PHE PHE A . n 
A 1 358 PHE 358 358 358 PHE PHE A . n 
A 1 359 LEU 359 359 359 LEU LEU A . n 
A 1 360 ILE 360 360 360 ILE ILE A . n 
A 1 361 ASN 361 361 361 ASN ASN A . n 
A 1 362 PRO 362 362 362 PRO PRO A . n 
A 1 363 THR 363 363 363 THR THR A . n 
A 1 364 LYS 364 364 364 LYS LYS A . n 
A 1 365 THR 365 365 365 THR THR A . n 
A 1 366 PHE 366 366 366 PHE PHE A . n 
A 1 367 TYR 367 367 367 TYR TYR A . n 
A 1 368 TYR 368 368 368 TYR TYR A . n 
A 1 369 LYS 369 369 369 LYS LYS A . n 
A 1 370 SER 370 370 370 SER SER A . n 
A 1 371 ARG 371 371 371 ARG ARG A . n 
A 1 372 PHE 372 372 372 PHE PHE A . n 
A 1 373 TRP 373 373 373 TRP TRP A . n 
A 1 374 LEU 374 374 374 LEU LEU A . n 
A 1 375 LEU 375 375 375 LEU LEU A . n 
A 1 376 LYS 376 376 376 LYS LYS A . n 
A 1 377 LEU 377 377 377 LEU LEU A . n 
A 1 378 LEU 378 378 378 LEU LEU A . n 
A 1 379 PHE 379 379 379 PHE PHE A . n 
A 1 380 ARG 380 380 380 ARG ARG A . n 
A 1 381 VAL 381 381 381 VAL VAL A . n 
A 1 382 PHE 382 382 382 PHE PHE A . n 
A 1 383 THR 383 383 383 THR THR A . n 
A 1 384 ALA 384 384 384 ALA ALA A . n 
A 1 385 PRO 385 385 385 PRO PRO A . n 
A 1 386 PHE 386 386 386 PHE PHE A . n 
A 1 387 HIS 387 387 387 HIS HIS A . n 
A 1 388 LYS 388 388 388 LYS LYS A . n 
A 1 389 VAL 389 389 389 VAL VAL A . n 
A 1 390 GLY 390 390 390 GLY GLY A . n 
A 1 391 PHE 391 391 391 PHE PHE A . n 
A 1 392 ALA 392 392 392 ALA ALA A . n 
A 1 393 ASP 393 393 393 ASP ASP A . n 
A 1 394 PHE 394 394 394 PHE PHE A . n 
A 1 395 TRP 395 395 395 TRP TRP A . n 
A 1 396 LEU 396 396 396 LEU LEU A . n 
A 1 397 ALA 397 397 397 ALA ALA A . n 
A 1 398 ASP 398 398 398 ASP ASP A . n 
A 1 399 GLN 399 399 399 GLN GLN A . n 
A 1 400 LEU 400 400 400 LEU LEU A . n 
A 1 401 ASN 401 401 401 ASN ASN A . n 
A 1 402 SER 402 402 402 SER SER A . n 
A 1 403 LEU 403 403 403 LEU LEU A . n 
A 1 404 SER 404 404 404 SER SER A . n 
A 1 405 VAL 405 405 405 VAL VAL A . n 
A 1 406 ILE 406 406 406 ILE ILE A . n 
A 1 407 LEU 407 407 407 LEU LEU A . n 
A 1 408 MET 408 408 408 MET MET A . n 
A 1 409 ASP 409 409 409 ASP ASP A . n 
A 1 410 LEU 410 410 410 LEU LEU A . n 
A 1 411 GLU 411 411 411 GLU GLU A . n 
A 1 412 TYR 412 412 412 TYR TYR A . n 
A 1 413 MET 413 413 413 MET MET A . n 
A 1 414 ILE 414 414 414 ILE ILE A . n 
A 1 415 CYS 415 415 415 CYS CYS A . n 
A 1 416 PHE 416 416 416 PHE PHE A . n 
A 1 417 TYR 417 417 417 TYR TYR A . n 
A 1 418 SER 418 418 418 SER SER A . n 
A 1 419 LEU 419 419 419 LEU LEU A . n 
A 1 420 GLU 420 420 420 GLU GLU A . n 
A 1 421 LEU 421 421 421 LEU LEU A . n 
A 1 422 LYS 422 422 422 LYS LYS A . n 
A 1 423 TRP 423 423 423 TRP TRP A . n 
A 1 424 ASP 424 424 424 ASP ASP A . n 
A 1 425 GLU 425 425 425 GLU GLU A . n 
A 1 426 SER 426 426 426 SER SER A . n 
A 1 427 LYS 427 427 427 LYS LYS A . n 
A 1 428 GLY 428 428 428 GLY GLY A . n 
A 1 429 LEU 429 429 429 LEU LEU A . n 
A 1 430 LEU 430 430 430 LEU LEU A . n 
A 1 431 PRO 431 431 431 PRO PRO A . n 
A 1 432 ASN 432 432 ?   ?   ?   A . n 
A 1 433 ASN 433 433 ?   ?   ?   A . n 
A 1 434 SER 434 434 ?   ?   ?   A . n 
A 1 435 GLU 435 435 ?   ?   ?   A . n 
A 1 436 GLU 436 436 ?   ?   ?   A . n 
A 1 437 SER 437 437 ?   ?   ?   A . n 
A 1 438 GLY 438 438 ?   ?   ?   A . n 
A 1 439 ILE 439 439 ?   ?   ?   A . n 
A 1 440 CYS 440 440 ?   ?   ?   A . n 
A 1 441 HIS 441 441 ?   ?   ?   A . n 
A 1 442 LYS 442 442 ?   ?   ?   A . n 
A 1 443 TYR 443 443 ?   ?   ?   A . n 
A 1 444 THR 444 444 ?   ?   ?   A . n 
A 1 445 TYR 445 445 ?   ?   ?   A . n 
A 1 446 GLY 446 446 446 GLY GLY A . n 
A 1 447 VAL 447 447 447 VAL VAL A . n 
A 1 448 ARG 448 448 448 ARG ARG A . n 
A 1 449 ALA 449 449 449 ALA ALA A . n 
A 1 450 ILE 450 450 450 ILE ILE A . n 
A 1 451 VAL 451 451 451 VAL VAL A . n 
A 1 452 GLN 452 452 452 GLN GLN A . n 
A 1 453 CYS 453 453 453 CYS CYS A . n 
A 1 454 ILE 454 454 454 ILE ILE A . n 
A 1 455 PRO 455 455 455 PRO PRO A . n 
A 1 456 ALA 456 456 456 ALA ALA A . n 
A 1 457 TRP 457 457 457 TRP TRP A . n 
A 1 458 LEU 458 458 458 LEU LEU A . n 
A 1 459 ARG 459 459 459 ARG ARG A . n 
A 1 460 PHE 460 460 460 PHE PHE A . n 
A 1 461 ILE 461 461 461 ILE ILE A . n 
A 1 462 GLN 462 462 462 GLN GLN A . n 
A 1 463 CYS 463 463 463 CYS CYS A . n 
A 1 464 LEU 464 464 464 LEU LEU A . n 
A 1 465 ARG 465 465 465 ARG ARG A . n 
A 1 466 ARG 466 466 466 ARG ARG A . n 
A 1 467 TYR 467 467 467 TYR TYR A . n 
A 1 468 ARG 468 468 468 ARG ARG A . n 
A 1 469 ASP 469 469 469 ASP ASP A . n 
A 1 470 THR 470 470 470 THR THR A . n 
A 1 471 LYS 471 471 471 LYS LYS A . n 
A 1 472 ARG 472 472 472 ARG ARG A . n 
A 1 473 ALA 473 473 473 ALA ALA A . n 
A 1 474 PHE 474 474 474 PHE PHE A . n 
A 1 475 PRO 475 475 475 PRO PRO A . n 
A 1 476 HIS 476 476 476 HIS HIS A . n 
A 1 477 LEU 477 477 477 LEU LEU A . n 
A 1 478 VAL 478 478 478 VAL VAL A . n 
A 1 479 ASN 479 479 479 ASN ASN A . n 
A 1 480 ALA 480 480 480 ALA ALA A . n 
A 1 481 GLY 481 481 481 GLY GLY A . n 
A 1 482 LYS 482 482 482 LYS LYS A . n 
A 1 483 TYR 483 483 483 TYR TYR A . n 
A 1 484 SER 484 484 484 SER SER A . n 
A 1 485 THR 485 485 485 THR THR A . n 
A 1 486 THR 486 486 486 THR THR A . n 
A 1 487 PHE 487 487 487 PHE PHE A . n 
A 1 488 PHE 488 488 488 PHE PHE A . n 
A 1 489 MET 489 489 489 MET MET A . n 
A 1 490 VAL 490 490 490 VAL VAL A . n 
A 1 491 THR 491 491 491 THR THR A . n 
A 1 492 PHE 492 492 492 PHE PHE A . n 
A 1 493 ALA 493 493 493 ALA ALA A . n 
A 1 494 ALA 494 494 494 ALA ALA A . n 
A 1 495 LEU 495 495 495 LEU LEU A . n 
A 1 496 TYR 496 496 496 TYR TYR A . n 
A 1 497 SER 497 497 497 SER SER A . n 
A 1 498 THR 498 498 498 THR THR A . n 
A 1 499 HIS 499 499 499 HIS HIS A . n 
A 1 500 LYS 500 500 500 LYS LYS A . n 
A 1 501 GLU 501 501 501 GLU GLU A . n 
A 1 502 ARG 502 502 502 ARG ARG A . n 
A 1 503 GLY 503 503 503 GLY GLY A . n 
A 1 504 HIS 504 504 504 HIS HIS A . n 
A 1 505 SER 505 505 505 SER SER A . n 
A 1 506 ASP 506 506 506 ASP ASP A . n 
A 1 507 THR 507 507 507 THR THR A . n 
A 1 508 MET 508 508 508 MET MET A . n 
A 1 509 VAL 509 509 509 VAL VAL A . n 
A 1 510 PHE 510 510 510 PHE PHE A . n 
A 1 511 PHE 511 511 511 PHE PHE A . n 
A 1 512 TYR 512 512 512 TYR TYR A . n 
A 1 513 LEU 513 513 513 LEU LEU A . n 
A 1 514 TRP 514 514 514 TRP TRP A . n 
A 1 515 ILE 515 515 515 ILE ILE A . n 
A 1 516 VAL 516 516 516 VAL VAL A . n 
A 1 517 PHE 517 517 517 PHE PHE A . n 
A 1 518 TYR 518 518 518 TYR TYR A . n 
A 1 519 ILE 519 519 519 ILE ILE A . n 
A 1 520 ILE 520 520 520 ILE ILE A . n 
A 1 521 SER 521 521 521 SER SER A . n 
A 1 522 SER 522 522 522 SER SER A . n 
A 1 523 CYS 523 523 523 CYS CYS A . n 
A 1 524 TYR 524 524 524 TYR TYR A . n 
A 1 525 THR 525 525 525 THR THR A . n 
A 1 526 LEU 526 526 526 LEU LEU A . n 
A 1 527 ILE 527 527 527 ILE ILE A . n 
A 1 528 TRP 528 528 528 TRP TRP A . n 
A 1 529 ASP 529 529 529 ASP ASP A . n 
A 1 530 LEU 530 530 530 LEU LEU A . n 
A 1 531 LYS 531 531 531 LYS LYS A . n 
A 1 532 MET 532 532 532 MET MET A . n 
A 1 533 ASP 533 533 533 ASP ASP A . n 
A 1 534 TRP 534 534 534 TRP TRP A . n 
A 1 535 GLY 535 535 535 GLY GLY A . n 
A 1 536 LEU 536 536 536 LEU LEU A . n 
A 1 537 PHE 537 537 537 PHE PHE A . n 
A 1 538 ASP 538 538 538 ASP ASP A . n 
A 1 539 LYS 539 539 539 LYS LYS A . n 
A 1 540 ASN 540 540 540 ASN ASN A . n 
A 1 541 ALA 541 541 541 ALA ALA A . n 
A 1 542 GLY 542 542 542 GLY GLY A . n 
A 1 543 GLU 543 543 543 GLU GLU A . n 
A 1 544 ASN 544 544 544 ASN ASN A . n 
A 1 545 THR 545 545 545 THR THR A . n 
A 1 546 PHE 546 546 546 PHE PHE A . n 
A 1 547 LEU 547 547 547 LEU LEU A . n 
A 1 548 ARG 548 548 548 ARG ARG A . n 
A 1 549 GLU 549 549 549 GLU GLU A . n 
A 1 550 GLU 550 550 550 GLU GLU A . n 
A 1 551 ILE 551 551 551 ILE ILE A . n 
A 1 552 VAL 552 552 552 VAL VAL A . n 
A 1 553 TYR 553 553 553 TYR TYR A . n 
A 1 554 PRO 554 554 554 PRO PRO A . n 
A 1 555 GLN 555 555 555 GLN GLN A . n 
A 1 556 LYS 556 556 556 LYS LYS A . n 
A 1 557 ALA 557 557 557 ALA ALA A . n 
A 1 558 TYR 558 558 558 TYR TYR A . n 
A 1 559 TYR 559 559 559 TYR TYR A . n 
A 1 560 TYR 560 560 560 TYR TYR A . n 
A 1 561 CYS 561 561 561 CYS CYS A . n 
A 1 562 ALA 562 562 562 ALA ALA A . n 
A 1 563 ILE 563 563 563 ILE ILE A . n 
A 1 564 ILE 564 564 564 ILE ILE A . n 
A 1 565 GLU 565 565 565 GLU GLU A . n 
A 1 566 ASP 566 566 566 ASP ASP A . n 
A 1 567 VAL 567 567 567 VAL VAL A . n 
A 1 568 ILE 568 568 568 ILE ILE A . n 
A 1 569 LEU 569 569 569 LEU LEU A . n 
A 1 570 ARG 570 570 570 ARG ARG A . n 
A 1 571 PHE 571 571 571 PHE PHE A . n 
A 1 572 ALA 572 572 572 ALA ALA A . n 
A 1 573 TRP 573 573 573 TRP TRP A . n 
A 1 574 THR 574 574 574 THR THR A . n 
A 1 575 ILE 575 575 575 ILE ILE A . n 
A 1 576 GLN 576 576 576 GLN GLN A . n 
A 1 577 ILE 577 577 577 ILE ILE A . n 
A 1 578 SER 578 578 578 SER SER A . n 
A 1 579 ILE 579 579 579 ILE ILE A . n 
A 1 580 THR 580 580 580 THR THR A . n 
A 1 581 SER 581 581 581 SER SER A . n 
A 1 582 THR 582 582 582 THR THR A . n 
A 1 583 THR 583 583 583 THR THR A . n 
A 1 584 LEU 584 584 584 LEU LEU A . n 
A 1 585 LEU 585 585 585 LEU LEU A . n 
A 1 586 PRO 586 586 586 PRO PRO A . n 
A 1 587 HIS 587 587 587 HIS HIS A . n 
A 1 588 SER 588 588 588 SER SER A . n 
A 1 589 GLY 589 589 589 GLY GLY A . n 
A 1 590 ASP 590 590 590 ASP ASP A . n 
A 1 591 ILE 591 591 591 ILE ILE A . n 
A 1 592 ILE 592 592 592 ILE ILE A . n 
A 1 593 ALA 593 593 593 ALA ALA A . n 
A 1 594 THR 594 594 594 THR THR A . n 
A 1 595 VAL 595 595 595 VAL VAL A . n 
A 1 596 PHE 596 596 596 PHE PHE A . n 
A 1 597 ALA 597 597 597 ALA ALA A . n 
A 1 598 PRO 598 598 598 PRO PRO A . n 
A 1 599 LEU 599 599 599 LEU LEU A . n 
A 1 600 GLU 600 600 600 GLU GLU A . n 
A 1 601 VAL 601 601 601 VAL VAL A . n 
A 1 602 PHE 602 602 602 PHE PHE A . n 
A 1 603 ARG 603 603 603 ARG ARG A . n 
A 1 604 ARG 604 604 604 ARG ARG A . n 
A 1 605 PHE 605 605 605 PHE PHE A . n 
A 1 606 VAL 606 606 606 VAL VAL A . n 
A 1 607 TRP 607 607 607 TRP TRP A . n 
A 1 608 ASN 608 608 608 ASN ASN A . n 
A 1 609 PHE 609 609 609 PHE PHE A . n 
A 1 610 PHE 610 610 610 PHE PHE A . n 
A 1 611 ARG 611 611 611 ARG ARG A . n 
A 1 612 LEU 612 612 612 LEU LEU A . n 
A 1 613 GLU 613 613 613 GLU GLU A . n 
A 1 614 ASN 614 614 614 ASN ASN A . n 
A 1 615 GLU 615 615 615 GLU GLU A . n 
A 1 616 HIS 616 616 616 HIS HIS A . n 
A 1 617 LEU 617 617 617 LEU LEU A . n 
A 1 618 ASN 618 618 618 ASN ASN A . n 
A 1 619 ASN 619 619 619 ASN ASN A . n 
A 1 620 CYS 620 620 620 CYS CYS A . n 
A 1 621 GLY 621 621 621 GLY GLY A . n 
A 1 622 GLU 622 622 622 GLU GLU A . n 
A 1 623 PHE 623 623 623 PHE PHE A . n 
A 1 624 ARG 624 624 624 ARG ARG A . n 
A 1 625 ALA 625 625 ?   ?   ?   A . n 
A 1 626 VAL 626 626 ?   ?   ?   A . n 
A 1 627 ARG 627 627 ?   ?   ?   A . n 
A 1 628 ASP 628 628 ?   ?   ?   A . n 
A 1 629 ILE 629 629 ?   ?   ?   A . n 
A 1 630 SER 630 630 ?   ?   ?   A . n 
A 1 631 VAL 631 631 ?   ?   ?   A . n 
A 1 632 ALA 632 632 ?   ?   ?   A . n 
A 1 633 PRO 633 633 ?   ?   ?   A . n 
A 1 634 LEU 634 634 ?   ?   ?   A . n 
A 1 635 ASN 635 635 ?   ?   ?   A . n 
A 1 636 ALA 636 636 ?   ?   ?   A . n 
A 1 637 ASP 637 637 ?   ?   ?   A . n 
A 1 638 ASP 638 638 ?   ?   ?   A . n 
A 1 639 GLN 639 639 ?   ?   ?   A . n 
A 1 640 THR 640 640 ?   ?   ?   A . n 
A 1 641 LEU 641 641 ?   ?   ?   A . n 
A 1 642 LEU 642 642 ?   ?   ?   A . n 
A 1 643 GLU 643 643 ?   ?   ?   A . n 
A 1 644 GLN 644 644 ?   ?   ?   A . n 
A 1 645 MET 645 645 ?   ?   ?   A . n 
A 1 646 MET 646 646 ?   ?   ?   A . n 
A 1 647 ASP 647 647 ?   ?   ?   A . n 
A 1 648 GLN 648 648 ?   ?   ?   A . n 
A 1 649 ASP 649 649 ?   ?   ?   A . n 
A 1 650 ASP 650 650 ?   ?   ?   A . n 
A 1 651 GLY 651 651 ?   ?   ?   A . n 
A 1 652 VAL 652 652 ?   ?   ?   A . n 
A 1 653 ARG 653 653 ?   ?   ?   A . n 
A 1 654 ASN 654 654 ?   ?   ?   A . n 
A 1 655 ARG 655 655 ?   ?   ?   A . n 
A 1 656 GLN 656 656 ?   ?   ?   A . n 
A 1 657 LYS 657 657 ?   ?   ?   A . n 
A 1 658 ASN 658 658 ?   ?   ?   A . n 
A 1 659 ARG 659 659 ?   ?   ?   A . n 
A 1 660 SER 660 660 ?   ?   ?   A . n 
A 1 661 TRP 661 661 ?   ?   ?   A . n 
A 1 662 LYS 662 662 ?   ?   ?   A . n 
A 1 663 TYR 663 663 ?   ?   ?   A . n 
A 1 664 ASN 664 664 ?   ?   ?   A . n 
A 1 665 GLN 665 665 ?   ?   ?   A . n 
A 1 666 SER 666 666 ?   ?   ?   A . n 
A 1 667 ILE 667 667 ?   ?   ?   A . n 
A 1 668 SER 668 668 ?   ?   ?   A . n 
A 1 669 LEU 669 669 ?   ?   ?   A . n 
A 1 670 ARG 670 670 ?   ?   ?   A . n 
A 1 671 ARG 671 671 ?   ?   ?   A . n 
A 1 672 PRO 672 672 ?   ?   ?   A . n 
A 1 673 ARG 673 673 ?   ?   ?   A . n 
A 1 674 LEU 674 674 ?   ?   ?   A . n 
A 1 675 ALA 675 675 ?   ?   ?   A . n 
A 1 676 SER 676 676 ?   ?   ?   A . n 
A 1 677 GLN 677 677 ?   ?   ?   A . n 
A 1 678 SER 678 678 ?   ?   ?   A . n 
A 1 679 LYS 679 679 ?   ?   ?   A . n 
A 1 680 ALA 680 680 ?   ?   ?   A . n 
A 1 681 ARG 681 681 ?   ?   ?   A . n 
A 1 682 ASP 682 682 ?   ?   ?   A . n 
A 1 683 THR 683 683 ?   ?   ?   A . n 
A 1 684 LYS 684 684 ?   ?   ?   A . n 
A 1 685 VAL 685 685 ?   ?   ?   A . n 
A 1 686 LEU 686 686 ?   ?   ?   A . n 
A 1 687 ILE 687 687 ?   ?   ?   A . n 
A 1 688 GLU 688 688 ?   ?   ?   A . n 
A 1 689 ASP 689 689 ?   ?   ?   A . n 
A 1 690 THR 690 690 ?   ?   ?   A . n 
A 1 691 ASP 691 691 ?   ?   ?   A . n 
A 1 692 ASP 692 692 ?   ?   ?   A . n 
A 1 693 GLU 693 693 ?   ?   ?   A . n 
A 1 694 ALA 694 694 ?   ?   ?   A . n 
A 1 695 ASN 695 695 ?   ?   ?   A . n 
A 1 696 THR 696 696 ?   ?   ?   A . n 
A 1 697 LEU 697 697 ?   ?   ?   A . n 
A 1 698 GLU 698 698 ?   ?   ?   A . n 
A 1 699 ASP 699 699 ?   ?   ?   A . n 
A 1 700 TYR 700 700 ?   ?   ?   A . n 
A 1 701 LYS 701 701 ?   ?   ?   A . n 
A 1 702 ASP 702 702 ?   ?   ?   A . n 
A 1 703 HIS 703 703 ?   ?   ?   A . n 
A 1 704 ASP 704 704 ?   ?   ?   A . n 
A 1 705 GLY 705 705 ?   ?   ?   A . n 
A 1 706 ASP 706 706 ?   ?   ?   A . n 
A 1 707 TYR 707 707 ?   ?   ?   A . n 
A 1 708 LYS 708 708 ?   ?   ?   A . n 
A 1 709 ASP 709 709 ?   ?   ?   A . n 
A 1 710 HIS 710 710 ?   ?   ?   A . n 
A 1 711 ASP 711 711 ?   ?   ?   A . n 
A 1 712 ILE 712 712 ?   ?   ?   A . n 
A 1 713 ASP 713 713 ?   ?   ?   A . n 
A 1 714 TYR 714 714 ?   ?   ?   A . n 
A 1 715 LYS 715 715 ?   ?   ?   A . n 
A 1 716 ASP 716 716 ?   ?   ?   A . n 
A 1 717 ASP 717 717 ?   ?   ?   A . n 
A 1 718 ASP 718 718 ?   ?   ?   A . n 
A 1 719 ASP 719 719 ?   ?   ?   A . n 
A 1 720 LYS 720 720 ?   ?   ?   A . n 
B 1 1   MET 1   1   ?   ?   ?   B . n 
B 1 2   LYS 2   2   ?   ?   ?   B . n 
B 1 3   PHE 3   3   ?   ?   ?   B . n 
B 1 4   ALA 4   4   ?   ?   ?   B . n 
B 1 5   GLU 5   5   ?   ?   ?   B . n 
B 1 6   HIS 6   6   ?   ?   ?   B . n 
B 1 7   LEU 7   7   ?   ?   ?   B . n 
B 1 8   SER 8   8   ?   ?   ?   B . n 
B 1 9   ALA 9   9   ?   ?   ?   B . n 
B 1 10  HIS 10  10  ?   ?   ?   B . n 
B 1 11  ILE 11  11  ?   ?   ?   B . n 
B 1 12  THR 12  12  ?   ?   ?   B . n 
B 1 13  PRO 13  13  ?   ?   ?   B . n 
B 1 14  GLU 14  14  ?   ?   ?   B . n 
B 1 15  TRP 15  15  ?   ?   ?   B . n 
B 1 16  ARG 16  16  ?   ?   ?   B . n 
B 1 17  LYS 17  17  ?   ?   ?   B . n 
B 1 18  GLN 18  18  ?   ?   ?   B . n 
B 1 19  TYR 19  19  ?   ?   ?   B . n 
B 1 20  ILE 20  20  ?   ?   ?   B . n 
B 1 21  GLN 21  21  ?   ?   ?   B . n 
B 1 22  TYR 22  22  ?   ?   ?   B . n 
B 1 23  GLU 23  23  ?   ?   ?   B . n 
B 1 24  ALA 24  24  ?   ?   ?   B . n 
B 1 25  PHE 25  25  ?   ?   ?   B . n 
B 1 26  LYS 26  26  ?   ?   ?   B . n 
B 1 27  ASP 27  27  ?   ?   ?   B . n 
B 1 28  MET 28  28  ?   ?   ?   B . n 
B 1 29  LEU 29  29  ?   ?   ?   B . n 
B 1 30  TYR 30  30  ?   ?   ?   B . n 
B 1 31  SER 31  31  ?   ?   ?   B . n 
B 1 32  ALA 32  32  ?   ?   ?   B . n 
B 1 33  GLN 33  33  ?   ?   ?   B . n 
B 1 34  ASP 34  34  ?   ?   ?   B . n 
B 1 35  GLN 35  35  ?   ?   ?   B . n 
B 1 36  ALA 36  36  ?   ?   ?   B . n 
B 1 37  PRO 37  37  ?   ?   ?   B . n 
B 1 38  SER 38  38  ?   ?   ?   B . n 
B 1 39  VAL 39  39  ?   ?   ?   B . n 
B 1 40  GLU 40  40  ?   ?   ?   B . n 
B 1 41  VAL 41  41  ?   ?   ?   B . n 
B 1 42  THR 42  42  ?   ?   ?   B . n 
B 1 43  ASP 43  43  ?   ?   ?   B . n 
B 1 44  GLU 44  44  ?   ?   ?   B . n 
B 1 45  ASP 45  45  ?   ?   ?   B . n 
B 1 46  THR 46  46  ?   ?   ?   B . n 
B 1 47  VAL 47  47  ?   ?   ?   B . n 
B 1 48  LYS 48  48  ?   ?   ?   B . n 
B 1 49  ARG 49  49  ?   ?   ?   B . n 
B 1 50  TYR 50  50  ?   ?   ?   B . n 
B 1 51  PHE 51  51  ?   ?   ?   B . n 
B 1 52  ALA 52  52  ?   ?   ?   B . n 
B 1 53  LYS 53  53  ?   ?   ?   B . n 
B 1 54  PHE 54  54  ?   ?   ?   B . n 
B 1 55  GLU 55  55  ?   ?   ?   B . n 
B 1 56  GLU 56  56  ?   ?   ?   B . n 
B 1 57  LYS 57  57  ?   ?   ?   B . n 
B 1 58  PHE 58  58  ?   ?   ?   B . n 
B 1 59  PHE 59  59  ?   ?   ?   B . n 
B 1 60  GLN 60  60  ?   ?   ?   B . n 
B 1 61  THR 61  61  ?   ?   ?   B . n 
B 1 62  CYS 62  62  ?   ?   ?   B . n 
B 1 63  GLU 63  63  ?   ?   ?   B . n 
B 1 64  LYS 64  64  ?   ?   ?   B . n 
B 1 65  GLU 65  65  ?   ?   ?   B . n 
B 1 66  LEU 66  66  ?   ?   ?   B . n 
B 1 67  ALA 67  67  ?   ?   ?   B . n 
B 1 68  LYS 68  68  ?   ?   ?   B . n 
B 1 69  ILE 69  69  ?   ?   ?   B . n 
B 1 70  ASN 70  70  ?   ?   ?   B . n 
B 1 71  THR 71  71  ?   ?   ?   B . n 
B 1 72  PHE 72  72  ?   ?   ?   B . n 
B 1 73  TYR 73  73  ?   ?   ?   B . n 
B 1 74  SER 74  74  ?   ?   ?   B . n 
B 1 75  GLU 75  75  ?   ?   ?   B . n 
B 1 76  LYS 76  76  ?   ?   ?   B . n 
B 1 77  LEU 77  77  ?   ?   ?   B . n 
B 1 78  ALA 78  78  ?   ?   ?   B . n 
B 1 79  GLU 79  79  ?   ?   ?   B . n 
B 1 80  ALA 80  80  ?   ?   ?   B . n 
B 1 81  GLN 81  81  ?   ?   ?   B . n 
B 1 82  ARG 82  82  ?   ?   ?   B . n 
B 1 83  ARG 83  83  ?   ?   ?   B . n 
B 1 84  PHE 84  84  ?   ?   ?   B . n 
B 1 85  ALA 85  85  ?   ?   ?   B . n 
B 1 86  THR 86  86  ?   ?   ?   B . n 
B 1 87  LEU 87  87  ?   ?   ?   B . n 
B 1 88  GLN 88  88  ?   ?   ?   B . n 
B 1 89  ASN 89  89  ?   ?   ?   B . n 
B 1 90  GLU 90  90  ?   ?   ?   B . n 
B 1 91  LEU 91  91  ?   ?   ?   B . n 
B 1 92  GLN 92  92  ?   ?   ?   B . n 
B 1 93  SER 93  93  ?   ?   ?   B . n 
B 1 94  SER 94  94  ?   ?   ?   B . n 
B 1 95  LEU 95  95  ?   ?   ?   B . n 
B 1 96  ASP 96  96  ?   ?   ?   B . n 
B 1 97  ALA 97  97  ?   ?   ?   B . n 
B 1 98  GLN 98  98  ?   ?   ?   B . n 
B 1 99  LYS 99  99  ?   ?   ?   B . n 
B 1 100 GLU 100 100 ?   ?   ?   B . n 
B 1 101 SER 101 101 ?   ?   ?   B . n 
B 1 102 THR 102 102 ?   ?   ?   B . n 
B 1 103 GLY 103 103 ?   ?   ?   B . n 
B 1 104 VAL 104 104 ?   ?   ?   B . n 
B 1 105 THR 105 105 ?   ?   ?   B . n 
B 1 106 THR 106 106 ?   ?   ?   B . n 
B 1 107 LEU 107 107 ?   ?   ?   B . n 
B 1 108 ARG 108 108 ?   ?   ?   B . n 
B 1 109 GLN 109 109 ?   ?   ?   B . n 
B 1 110 ARG 110 110 ?   ?   ?   B . n 
B 1 111 ARG 111 111 ?   ?   ?   B . n 
B 1 112 LYS 112 112 ?   ?   ?   B . n 
B 1 113 PRO 113 113 ?   ?   ?   B . n 
B 1 114 VAL 114 114 ?   ?   ?   B . n 
B 1 115 PHE 115 115 ?   ?   ?   B . n 
B 1 116 HIS 116 116 ?   ?   ?   B . n 
B 1 117 LEU 117 117 ?   ?   ?   B . n 
B 1 118 SER 118 118 ?   ?   ?   B . n 
B 1 119 HIS 119 119 ?   ?   ?   B . n 
B 1 120 GLU 120 120 ?   ?   ?   B . n 
B 1 121 GLU 121 121 ?   ?   ?   B . n 
B 1 122 ARG 122 122 ?   ?   ?   B . n 
B 1 123 VAL 123 123 ?   ?   ?   B . n 
B 1 124 GLN 124 124 ?   ?   ?   B . n 
B 1 125 HIS 125 125 ?   ?   ?   B . n 
B 1 126 ARG 126 126 ?   ?   ?   B . n 
B 1 127 ASN 127 127 ?   ?   ?   B . n 
B 1 128 ILE 128 128 ?   ?   ?   B . n 
B 1 129 LYS 129 129 ?   ?   ?   B . n 
B 1 130 ASP 130 130 ?   ?   ?   B . n 
B 1 131 LEU 131 131 ?   ?   ?   B . n 
B 1 132 LYS 132 132 ?   ?   ?   B . n 
B 1 133 LEU 133 133 ?   ?   ?   B . n 
B 1 134 ALA 134 134 ?   ?   ?   B . n 
B 1 135 PHE 135 135 ?   ?   ?   B . n 
B 1 136 SER 136 136 ?   ?   ?   B . n 
B 1 137 GLU 137 137 ?   ?   ?   B . n 
B 1 138 PHE 138 138 ?   ?   ?   B . n 
B 1 139 TYR 139 139 ?   ?   ?   B . n 
B 1 140 LEU 140 140 ?   ?   ?   B . n 
B 1 141 SER 141 141 ?   ?   ?   B . n 
B 1 142 LEU 142 142 ?   ?   ?   B . n 
B 1 143 ILE 143 143 ?   ?   ?   B . n 
B 1 144 LEU 144 144 ?   ?   ?   B . n 
B 1 145 LEU 145 145 ?   ?   ?   B . n 
B 1 146 GLN 146 146 ?   ?   ?   B . n 
B 1 147 ASN 147 147 ?   ?   ?   B . n 
B 1 148 TYR 148 148 ?   ?   ?   B . n 
B 1 149 GLN 149 149 ?   ?   ?   B . n 
B 1 150 ASN 150 150 ?   ?   ?   B . n 
B 1 151 LEU 151 151 ?   ?   ?   B . n 
B 1 152 ASN 152 152 ?   ?   ?   B . n 
B 1 153 PHE 153 153 ?   ?   ?   B . n 
B 1 154 THR 154 154 ?   ?   ?   B . n 
B 1 155 GLY 155 155 ?   ?   ?   B . n 
B 1 156 PHE 156 156 ?   ?   ?   B . n 
B 1 157 ARG 157 157 ?   ?   ?   B . n 
B 1 158 LYS 158 158 ?   ?   ?   B . n 
B 1 159 ILE 159 159 ?   ?   ?   B . n 
B 1 160 LEU 160 160 ?   ?   ?   B . n 
B 1 161 LYS 161 161 ?   ?   ?   B . n 
B 1 162 LYS 162 162 ?   ?   ?   B . n 
B 1 163 HIS 163 163 ?   ?   ?   B . n 
B 1 164 ASP 164 164 ?   ?   ?   B . n 
B 1 165 LYS 165 165 ?   ?   ?   B . n 
B 1 166 ILE 166 166 ?   ?   ?   B . n 
B 1 167 LEU 167 167 ?   ?   ?   B . n 
B 1 168 GLU 168 168 ?   ?   ?   B . n 
B 1 169 THR 169 169 ?   ?   ?   B . n 
B 1 170 SER 170 170 ?   ?   ?   B . n 
B 1 171 ARG 171 171 ?   ?   ?   B . n 
B 1 172 GLY 172 172 ?   ?   ?   B . n 
B 1 173 ALA 173 173 ?   ?   ?   B . n 
B 1 174 ASP 174 174 ?   ?   ?   B . n 
B 1 175 TRP 175 175 ?   ?   ?   B . n 
B 1 176 ARG 176 176 ?   ?   ?   B . n 
B 1 177 VAL 177 177 ?   ?   ?   B . n 
B 1 178 ALA 178 178 ?   ?   ?   B . n 
B 1 179 HIS 179 179 ?   ?   ?   B . n 
B 1 180 VAL 180 180 ?   ?   ?   B . n 
B 1 181 GLU 181 181 ?   ?   ?   B . n 
B 1 182 VAL 182 182 ?   ?   ?   B . n 
B 1 183 ALA 183 183 ?   ?   ?   B . n 
B 1 184 PRO 184 184 ?   ?   ?   B . n 
B 1 185 PHE 185 185 ?   ?   ?   B . n 
B 1 186 TYR 186 186 ?   ?   ?   B . n 
B 1 187 THR 187 187 ?   ?   ?   B . n 
B 1 188 CYS 188 188 ?   ?   ?   B . n 
B 1 189 LYS 189 189 ?   ?   ?   B . n 
B 1 190 LYS 190 190 ?   ?   ?   B . n 
B 1 191 ILE 191 191 ?   ?   ?   B . n 
B 1 192 ASN 192 192 ?   ?   ?   B . n 
B 1 193 GLN 193 193 ?   ?   ?   B . n 
B 1 194 LEU 194 194 ?   ?   ?   B . n 
B 1 195 ILE 195 195 ?   ?   ?   B . n 
B 1 196 SER 196 196 ?   ?   ?   B . n 
B 1 197 GLU 197 197 ?   ?   ?   B . n 
B 1 198 THR 198 198 ?   ?   ?   B . n 
B 1 199 GLU 199 199 ?   ?   ?   B . n 
B 1 200 ALA 200 200 ?   ?   ?   B . n 
B 1 201 VAL 201 201 ?   ?   ?   B . n 
B 1 202 VAL 202 202 ?   ?   ?   B . n 
B 1 203 THR 203 203 ?   ?   ?   B . n 
B 1 204 ASN 204 204 ?   ?   ?   B . n 
B 1 205 GLU 205 205 ?   ?   ?   B . n 
B 1 206 LEU 206 206 ?   ?   ?   B . n 
B 1 207 GLU 207 207 ?   ?   ?   B . n 
B 1 208 ASP 208 208 ?   ?   ?   B . n 
B 1 209 GLY 209 209 ?   ?   ?   B . n 
B 1 210 ASP 210 210 ?   ?   ?   B . n 
B 1 211 ARG 211 211 ?   ?   ?   B . n 
B 1 212 GLN 212 212 ?   ?   ?   B . n 
B 1 213 LYS 213 213 ?   ?   ?   B . n 
B 1 214 ALA 214 214 ?   ?   ?   B . n 
B 1 215 MET 215 215 ?   ?   ?   B . n 
B 1 216 LYS 216 216 ?   ?   ?   B . n 
B 1 217 ARG 217 217 ?   ?   ?   B . n 
B 1 218 LEU 218 218 ?   ?   ?   B . n 
B 1 219 ARG 219 219 ?   ?   ?   B . n 
B 1 220 VAL 220 220 ?   ?   ?   B . n 
B 1 221 PRO 221 221 ?   ?   ?   B . n 
B 1 222 PRO 222 222 ?   ?   ?   B . n 
B 1 223 LEU 223 223 ?   ?   ?   B . n 
B 1 224 GLY 224 224 ?   ?   ?   B . n 
B 1 225 ALA 225 225 ?   ?   ?   B . n 
B 1 226 ALA 226 226 ?   ?   ?   B . n 
B 1 227 GLN 227 227 ?   ?   ?   B . n 
B 1 228 PRO 228 228 ?   ?   ?   B . n 
B 1 229 ALA 229 229 229 ALA ALA B . n 
B 1 230 PRO 230 230 230 PRO PRO B . n 
B 1 231 ALA 231 231 231 ALA ALA B . n 
B 1 232 TRP 232 232 232 TRP TRP B . n 
B 1 233 THR 233 233 233 THR THR B . n 
B 1 234 THR 234 234 234 THR THR B . n 
B 1 235 PHE 235 235 235 PHE PHE B . n 
B 1 236 ARG 236 236 236 ARG ARG B . n 
B 1 237 VAL 237 237 237 VAL VAL B . n 
B 1 238 GLY 238 238 238 GLY GLY B . n 
B 1 239 LEU 239 239 239 LEU LEU B . n 
B 1 240 PHE 240 240 240 PHE PHE B . n 
B 1 241 CYS 241 241 241 CYS CYS B . n 
B 1 242 GLY 242 242 242 GLY GLY B . n 
B 1 243 ILE 243 243 243 ILE ILE B . n 
B 1 244 PHE 244 244 244 PHE PHE B . n 
B 1 245 ILE 245 245 245 ILE ILE B . n 
B 1 246 VAL 246 246 246 VAL VAL B . n 
B 1 247 LEU 247 247 247 LEU LEU B . n 
B 1 248 ASN 248 248 248 ASN ASN B . n 
B 1 249 ILE 249 249 249 ILE ILE B . n 
B 1 250 THR 250 250 250 THR THR B . n 
B 1 251 LEU 251 251 251 LEU LEU B . n 
B 1 252 VAL 252 252 252 VAL VAL B . n 
B 1 253 LEU 253 253 253 LEU LEU B . n 
B 1 254 ALA 254 254 254 ALA ALA B . n 
B 1 255 ALA 255 255 255 ALA ALA B . n 
B 1 256 VAL 256 256 256 VAL VAL B . n 
B 1 257 PHE 257 257 257 PHE PHE B . n 
B 1 258 LYS 258 258 258 LYS LYS B . n 
B 1 259 LEU 259 259 259 LEU LEU B . n 
B 1 260 GLU 260 260 260 GLU GLU B . n 
B 1 261 THR 261 261 261 THR THR B . n 
B 1 262 ASP 262 262 262 ASP ASP B . n 
B 1 263 ARG 263 263 263 ARG ARG B . n 
B 1 264 SER 264 264 264 SER SER B . n 
B 1 265 ILE 265 265 265 ILE ILE B . n 
B 1 266 TRP 266 266 266 TRP TRP B . n 
B 1 267 PRO 267 267 267 PRO PRO B . n 
B 1 268 LEU 268 268 268 LEU LEU B . n 
B 1 269 ILE 269 269 269 ILE ILE B . n 
B 1 270 ARG 270 270 270 ARG ARG B . n 
B 1 271 ILE 271 271 271 ILE ILE B . n 
B 1 272 TYR 272 272 272 TYR TYR B . n 
B 1 273 ARG 273 273 273 ARG ARG B . n 
B 1 274 GLY 274 274 274 GLY GLY B . n 
B 1 275 GLY 275 275 275 GLY GLY B . n 
B 1 276 PHE 276 276 276 PHE PHE B . n 
B 1 277 LEU 277 277 277 LEU LEU B . n 
B 1 278 LEU 278 278 278 LEU LEU B . n 
B 1 279 ILE 279 279 279 ILE ILE B . n 
B 1 280 GLU 280 280 280 GLU GLU B . n 
B 1 281 PHE 281 281 281 PHE PHE B . n 
B 1 282 LEU 282 282 282 LEU LEU B . n 
B 1 283 PHE 283 283 283 PHE PHE B . n 
B 1 284 LEU 284 284 284 LEU LEU B . n 
B 1 285 LEU 285 285 285 LEU LEU B . n 
B 1 286 GLY 286 286 286 GLY GLY B . n 
B 1 287 ILE 287 287 287 ILE ILE B . n 
B 1 288 ASN 288 288 288 ASN ASN B . n 
B 1 289 THR 289 289 289 THR THR B . n 
B 1 290 TYR 290 290 290 TYR TYR B . n 
B 1 291 GLY 291 291 291 GLY GLY B . n 
B 1 292 TRP 292 292 292 TRP TRP B . n 
B 1 293 ARG 293 293 293 ARG ARG B . n 
B 1 294 GLN 294 294 294 GLN GLN B . n 
B 1 295 ALA 295 295 295 ALA ALA B . n 
B 1 296 GLY 296 296 296 GLY GLY B . n 
B 1 297 VAL 297 297 297 VAL VAL B . n 
B 1 298 ASN 298 298 298 ASN ASN B . n 
B 1 299 HIS 299 299 299 HIS HIS B . n 
B 1 300 VAL 300 300 300 VAL VAL B . n 
B 1 301 LEU 301 301 301 LEU LEU B . n 
B 1 302 ILE 302 302 302 ILE ILE B . n 
B 1 303 PHE 303 303 303 PHE PHE B . n 
B 1 304 GLU 304 304 304 GLU GLU B . n 
B 1 305 LEU 305 305 305 LEU LEU B . n 
B 1 306 ASN 306 306 306 ASN ASN B . n 
B 1 307 PRO 307 307 307 PRO PRO B . n 
B 1 308 ARG 308 308 308 ARG ARG B . n 
B 1 309 SER 309 309 309 SER SER B . n 
B 1 310 ASN 310 310 310 ASN ASN B . n 
B 1 311 LEU 311 311 311 LEU LEU B . n 
B 1 312 SER 312 312 312 SER SER B . n 
B 1 313 HIS 313 313 313 HIS HIS B . n 
B 1 314 GLN 314 314 314 GLN GLN B . n 
B 1 315 HIS 315 315 315 HIS HIS B . n 
B 1 316 LEU 316 316 316 LEU LEU B . n 
B 1 317 PHE 317 317 317 PHE PHE B . n 
B 1 318 GLU 318 318 318 GLU GLU B . n 
B 1 319 ILE 319 319 319 ILE ILE B . n 
B 1 320 ALA 320 320 320 ALA ALA B . n 
B 1 321 GLY 321 321 321 GLY GLY B . n 
B 1 322 PHE 322 322 322 PHE PHE B . n 
B 1 323 LEU 323 323 323 LEU LEU B . n 
B 1 324 GLY 324 324 324 GLY GLY B . n 
B 1 325 ILE 325 325 325 ILE ILE B . n 
B 1 326 LEU 326 326 326 LEU LEU B . n 
B 1 327 TRP 327 327 327 TRP TRP B . n 
B 1 328 CYS 328 328 328 CYS CYS B . n 
B 1 329 LEU 329 329 329 LEU LEU B . n 
B 1 330 SER 330 330 330 SER SER B . n 
B 1 331 LEU 331 331 331 LEU LEU B . n 
B 1 332 LEU 332 332 332 LEU LEU B . n 
B 1 333 ALA 333 333 333 ALA ALA B . n 
B 1 334 CYS 334 334 334 CYS CYS B . n 
B 1 335 PHE 335 335 335 PHE PHE B . n 
B 1 336 PHE 336 336 336 PHE PHE B . n 
B 1 337 ALA 337 337 337 ALA ALA B . n 
B 1 338 PRO 338 338 338 PRO PRO B . n 
B 1 339 ILE 339 339 339 ILE ILE B . n 
B 1 340 SER 340 340 340 SER SER B . n 
B 1 341 VAL 341 341 341 VAL VAL B . n 
B 1 342 ILE 342 342 342 ILE ILE B . n 
B 1 343 PRO 343 343 343 PRO PRO B . n 
B 1 344 THR 344 344 344 THR THR B . n 
B 1 345 TYR 345 345 345 TYR TYR B . n 
B 1 346 VAL 346 346 346 VAL VAL B . n 
B 1 347 TYR 347 347 347 TYR TYR B . n 
B 1 348 PRO 348 348 348 PRO PRO B . n 
B 1 349 LEU 349 349 349 LEU LEU B . n 
B 1 350 ALA 350 350 350 ALA ALA B . n 
B 1 351 LEU 351 351 351 LEU LEU B . n 
B 1 352 TYR 352 352 352 TYR TYR B . n 
B 1 353 GLY 353 353 353 GLY GLY B . n 
B 1 354 PHE 354 354 354 PHE PHE B . n 
B 1 355 MET 355 355 355 MET MET B . n 
B 1 356 VAL 356 356 356 VAL VAL B . n 
B 1 357 PHE 357 357 357 PHE PHE B . n 
B 1 358 PHE 358 358 358 PHE PHE B . n 
B 1 359 LEU 359 359 359 LEU LEU B . n 
B 1 360 ILE 360 360 360 ILE ILE B . n 
B 1 361 ASN 361 361 361 ASN ASN B . n 
B 1 362 PRO 362 362 362 PRO PRO B . n 
B 1 363 THR 363 363 363 THR THR B . n 
B 1 364 LYS 364 364 364 LYS LYS B . n 
B 1 365 THR 365 365 365 THR THR B . n 
B 1 366 PHE 366 366 366 PHE PHE B . n 
B 1 367 TYR 367 367 367 TYR TYR B . n 
B 1 368 TYR 368 368 368 TYR TYR B . n 
B 1 369 LYS 369 369 369 LYS LYS B . n 
B 1 370 SER 370 370 370 SER SER B . n 
B 1 371 ARG 371 371 371 ARG ARG B . n 
B 1 372 PHE 372 372 372 PHE PHE B . n 
B 1 373 TRP 373 373 373 TRP TRP B . n 
B 1 374 LEU 374 374 374 LEU LEU B . n 
B 1 375 LEU 375 375 375 LEU LEU B . n 
B 1 376 LYS 376 376 376 LYS LYS B . n 
B 1 377 LEU 377 377 377 LEU LEU B . n 
B 1 378 LEU 378 378 378 LEU LEU B . n 
B 1 379 PHE 379 379 379 PHE PHE B . n 
B 1 380 ARG 380 380 380 ARG ARG B . n 
B 1 381 VAL 381 381 381 VAL VAL B . n 
B 1 382 PHE 382 382 382 PHE PHE B . n 
B 1 383 THR 383 383 383 THR THR B . n 
B 1 384 ALA 384 384 384 ALA ALA B . n 
B 1 385 PRO 385 385 385 PRO PRO B . n 
B 1 386 PHE 386 386 386 PHE PHE B . n 
B 1 387 HIS 387 387 387 HIS HIS B . n 
B 1 388 LYS 388 388 388 LYS LYS B . n 
B 1 389 VAL 389 389 389 VAL VAL B . n 
B 1 390 GLY 390 390 390 GLY GLY B . n 
B 1 391 PHE 391 391 391 PHE PHE B . n 
B 1 392 ALA 392 392 392 ALA ALA B . n 
B 1 393 ASP 393 393 393 ASP ASP B . n 
B 1 394 PHE 394 394 394 PHE PHE B . n 
B 1 395 TRP 395 395 395 TRP TRP B . n 
B 1 396 LEU 396 396 396 LEU LEU B . n 
B 1 397 ALA 397 397 397 ALA ALA B . n 
B 1 398 ASP 398 398 398 ASP ASP B . n 
B 1 399 GLN 399 399 399 GLN GLN B . n 
B 1 400 LEU 400 400 400 LEU LEU B . n 
B 1 401 ASN 401 401 401 ASN ASN B . n 
B 1 402 SER 402 402 402 SER SER B . n 
B 1 403 LEU 403 403 403 LEU LEU B . n 
B 1 404 SER 404 404 404 SER SER B . n 
B 1 405 VAL 405 405 405 VAL VAL B . n 
B 1 406 ILE 406 406 406 ILE ILE B . n 
B 1 407 LEU 407 407 407 LEU LEU B . n 
B 1 408 MET 408 408 408 MET MET B . n 
B 1 409 ASP 409 409 409 ASP ASP B . n 
B 1 410 LEU 410 410 410 LEU LEU B . n 
B 1 411 GLU 411 411 411 GLU GLU B . n 
B 1 412 TYR 412 412 412 TYR TYR B . n 
B 1 413 MET 413 413 413 MET MET B . n 
B 1 414 ILE 414 414 414 ILE ILE B . n 
B 1 415 CYS 415 415 415 CYS CYS B . n 
B 1 416 PHE 416 416 416 PHE PHE B . n 
B 1 417 TYR 417 417 417 TYR TYR B . n 
B 1 418 SER 418 418 418 SER SER B . n 
B 1 419 LEU 419 419 419 LEU LEU B . n 
B 1 420 GLU 420 420 420 GLU GLU B . n 
B 1 421 LEU 421 421 421 LEU LEU B . n 
B 1 422 LYS 422 422 422 LYS LYS B . n 
B 1 423 TRP 423 423 423 TRP TRP B . n 
B 1 424 ASP 424 424 424 ASP ASP B . n 
B 1 425 GLU 425 425 425 GLU GLU B . n 
B 1 426 SER 426 426 426 SER SER B . n 
B 1 427 LYS 427 427 427 LYS LYS B . n 
B 1 428 GLY 428 428 428 GLY GLY B . n 
B 1 429 LEU 429 429 429 LEU LEU B . n 
B 1 430 LEU 430 430 430 LEU LEU B . n 
B 1 431 PRO 431 431 431 PRO PRO B . n 
B 1 432 ASN 432 432 ?   ?   ?   B . n 
B 1 433 ASN 433 433 ?   ?   ?   B . n 
B 1 434 SER 434 434 ?   ?   ?   B . n 
B 1 435 GLU 435 435 ?   ?   ?   B . n 
B 1 436 GLU 436 436 ?   ?   ?   B . n 
B 1 437 SER 437 437 ?   ?   ?   B . n 
B 1 438 GLY 438 438 ?   ?   ?   B . n 
B 1 439 ILE 439 439 ?   ?   ?   B . n 
B 1 440 CYS 440 440 ?   ?   ?   B . n 
B 1 441 HIS 441 441 ?   ?   ?   B . n 
B 1 442 LYS 442 442 ?   ?   ?   B . n 
B 1 443 TYR 443 443 ?   ?   ?   B . n 
B 1 444 THR 444 444 ?   ?   ?   B . n 
B 1 445 TYR 445 445 ?   ?   ?   B . n 
B 1 446 GLY 446 446 446 GLY GLY B . n 
B 1 447 VAL 447 447 447 VAL VAL B . n 
B 1 448 ARG 448 448 448 ARG ARG B . n 
B 1 449 ALA 449 449 449 ALA ALA B . n 
B 1 450 ILE 450 450 450 ILE ILE B . n 
B 1 451 VAL 451 451 451 VAL VAL B . n 
B 1 452 GLN 452 452 452 GLN GLN B . n 
B 1 453 CYS 453 453 453 CYS CYS B . n 
B 1 454 ILE 454 454 454 ILE ILE B . n 
B 1 455 PRO 455 455 455 PRO PRO B . n 
B 1 456 ALA 456 456 456 ALA ALA B . n 
B 1 457 TRP 457 457 457 TRP TRP B . n 
B 1 458 LEU 458 458 458 LEU LEU B . n 
B 1 459 ARG 459 459 459 ARG ARG B . n 
B 1 460 PHE 460 460 460 PHE PHE B . n 
B 1 461 ILE 461 461 461 ILE ILE B . n 
B 1 462 GLN 462 462 462 GLN GLN B . n 
B 1 463 CYS 463 463 463 CYS CYS B . n 
B 1 464 LEU 464 464 464 LEU LEU B . n 
B 1 465 ARG 465 465 465 ARG ARG B . n 
B 1 466 ARG 466 466 466 ARG ARG B . n 
B 1 467 TYR 467 467 467 TYR TYR B . n 
B 1 468 ARG 468 468 468 ARG ARG B . n 
B 1 469 ASP 469 469 469 ASP ASP B . n 
B 1 470 THR 470 470 470 THR THR B . n 
B 1 471 LYS 471 471 471 LYS LYS B . n 
B 1 472 ARG 472 472 472 ARG ARG B . n 
B 1 473 ALA 473 473 473 ALA ALA B . n 
B 1 474 PHE 474 474 474 PHE PHE B . n 
B 1 475 PRO 475 475 475 PRO PRO B . n 
B 1 476 HIS 476 476 476 HIS HIS B . n 
B 1 477 LEU 477 477 477 LEU LEU B . n 
B 1 478 VAL 478 478 478 VAL VAL B . n 
B 1 479 ASN 479 479 479 ASN ASN B . n 
B 1 480 ALA 480 480 480 ALA ALA B . n 
B 1 481 GLY 481 481 481 GLY GLY B . n 
B 1 482 LYS 482 482 482 LYS LYS B . n 
B 1 483 TYR 483 483 483 TYR TYR B . n 
B 1 484 SER 484 484 484 SER SER B . n 
B 1 485 THR 485 485 485 THR THR B . n 
B 1 486 THR 486 486 486 THR THR B . n 
B 1 487 PHE 487 487 487 PHE PHE B . n 
B 1 488 PHE 488 488 488 PHE PHE B . n 
B 1 489 MET 489 489 489 MET MET B . n 
B 1 490 VAL 490 490 490 VAL VAL B . n 
B 1 491 THR 491 491 491 THR THR B . n 
B 1 492 PHE 492 492 492 PHE PHE B . n 
B 1 493 ALA 493 493 493 ALA ALA B . n 
B 1 494 ALA 494 494 494 ALA ALA B . n 
B 1 495 LEU 495 495 495 LEU LEU B . n 
B 1 496 TYR 496 496 496 TYR TYR B . n 
B 1 497 SER 497 497 497 SER SER B . n 
B 1 498 THR 498 498 498 THR THR B . n 
B 1 499 HIS 499 499 499 HIS HIS B . n 
B 1 500 LYS 500 500 500 LYS LYS B . n 
B 1 501 GLU 501 501 501 GLU GLU B . n 
B 1 502 ARG 502 502 502 ARG ARG B . n 
B 1 503 GLY 503 503 503 GLY GLY B . n 
B 1 504 HIS 504 504 504 HIS HIS B . n 
B 1 505 SER 505 505 505 SER SER B . n 
B 1 506 ASP 506 506 506 ASP ASP B . n 
B 1 507 THR 507 507 507 THR THR B . n 
B 1 508 MET 508 508 508 MET MET B . n 
B 1 509 VAL 509 509 509 VAL VAL B . n 
B 1 510 PHE 510 510 510 PHE PHE B . n 
B 1 511 PHE 511 511 511 PHE PHE B . n 
B 1 512 TYR 512 512 512 TYR TYR B . n 
B 1 513 LEU 513 513 513 LEU LEU B . n 
B 1 514 TRP 514 514 514 TRP TRP B . n 
B 1 515 ILE 515 515 515 ILE ILE B . n 
B 1 516 VAL 516 516 516 VAL VAL B . n 
B 1 517 PHE 517 517 517 PHE PHE B . n 
B 1 518 TYR 518 518 518 TYR TYR B . n 
B 1 519 ILE 519 519 519 ILE ILE B . n 
B 1 520 ILE 520 520 520 ILE ILE B . n 
B 1 521 SER 521 521 521 SER SER B . n 
B 1 522 SER 522 522 522 SER SER B . n 
B 1 523 CYS 523 523 523 CYS CYS B . n 
B 1 524 TYR 524 524 524 TYR TYR B . n 
B 1 525 THR 525 525 525 THR THR B . n 
B 1 526 LEU 526 526 526 LEU LEU B . n 
B 1 527 ILE 527 527 527 ILE ILE B . n 
B 1 528 TRP 528 528 528 TRP TRP B . n 
B 1 529 ASP 529 529 529 ASP ASP B . n 
B 1 530 LEU 530 530 530 LEU LEU B . n 
B 1 531 LYS 531 531 531 LYS LYS B . n 
B 1 532 MET 532 532 532 MET MET B . n 
B 1 533 ASP 533 533 533 ASP ASP B . n 
B 1 534 TRP 534 534 534 TRP TRP B . n 
B 1 535 GLY 535 535 535 GLY GLY B . n 
B 1 536 LEU 536 536 536 LEU LEU B . n 
B 1 537 PHE 537 537 537 PHE PHE B . n 
B 1 538 ASP 538 538 538 ASP ASP B . n 
B 1 539 LYS 539 539 539 LYS LYS B . n 
B 1 540 ASN 540 540 540 ASN ASN B . n 
B 1 541 ALA 541 541 541 ALA ALA B . n 
B 1 542 GLY 542 542 542 GLY GLY B . n 
B 1 543 GLU 543 543 543 GLU GLU B . n 
B 1 544 ASN 544 544 544 ASN ASN B . n 
B 1 545 THR 545 545 545 THR THR B . n 
B 1 546 PHE 546 546 546 PHE PHE B . n 
B 1 547 LEU 547 547 547 LEU LEU B . n 
B 1 548 ARG 548 548 548 ARG ARG B . n 
B 1 549 GLU 549 549 549 GLU GLU B . n 
B 1 550 GLU 550 550 550 GLU GLU B . n 
B 1 551 ILE 551 551 551 ILE ILE B . n 
B 1 552 VAL 552 552 552 VAL VAL B . n 
B 1 553 TYR 553 553 553 TYR TYR B . n 
B 1 554 PRO 554 554 554 PRO PRO B . n 
B 1 555 GLN 555 555 555 GLN GLN B . n 
B 1 556 LYS 556 556 556 LYS LYS B . n 
B 1 557 ALA 557 557 557 ALA ALA B . n 
B 1 558 TYR 558 558 558 TYR TYR B . n 
B 1 559 TYR 559 559 559 TYR TYR B . n 
B 1 560 TYR 560 560 560 TYR TYR B . n 
B 1 561 CYS 561 561 561 CYS CYS B . n 
B 1 562 ALA 562 562 562 ALA ALA B . n 
B 1 563 ILE 563 563 563 ILE ILE B . n 
B 1 564 ILE 564 564 564 ILE ILE B . n 
B 1 565 GLU 565 565 565 GLU GLU B . n 
B 1 566 ASP 566 566 566 ASP ASP B . n 
B 1 567 VAL 567 567 567 VAL VAL B . n 
B 1 568 ILE 568 568 568 ILE ILE B . n 
B 1 569 LEU 569 569 569 LEU LEU B . n 
B 1 570 ARG 570 570 570 ARG ARG B . n 
B 1 571 PHE 571 571 571 PHE PHE B . n 
B 1 572 ALA 572 572 572 ALA ALA B . n 
B 1 573 TRP 573 573 573 TRP TRP B . n 
B 1 574 THR 574 574 574 THR THR B . n 
B 1 575 ILE 575 575 575 ILE ILE B . n 
B 1 576 GLN 576 576 576 GLN GLN B . n 
B 1 577 ILE 577 577 577 ILE ILE B . n 
B 1 578 SER 578 578 578 SER SER B . n 
B 1 579 ILE 579 579 579 ILE ILE B . n 
B 1 580 THR 580 580 580 THR THR B . n 
B 1 581 SER 581 581 581 SER SER B . n 
B 1 582 THR 582 582 582 THR THR B . n 
B 1 583 THR 583 583 583 THR THR B . n 
B 1 584 LEU 584 584 584 LEU LEU B . n 
B 1 585 LEU 585 585 585 LEU LEU B . n 
B 1 586 PRO 586 586 586 PRO PRO B . n 
B 1 587 HIS 587 587 587 HIS HIS B . n 
B 1 588 SER 588 588 588 SER SER B . n 
B 1 589 GLY 589 589 589 GLY GLY B . n 
B 1 590 ASP 590 590 590 ASP ASP B . n 
B 1 591 ILE 591 591 591 ILE ILE B . n 
B 1 592 ILE 592 592 592 ILE ILE B . n 
B 1 593 ALA 593 593 593 ALA ALA B . n 
B 1 594 THR 594 594 594 THR THR B . n 
B 1 595 VAL 595 595 595 VAL VAL B . n 
B 1 596 PHE 596 596 596 PHE PHE B . n 
B 1 597 ALA 597 597 597 ALA ALA B . n 
B 1 598 PRO 598 598 598 PRO PRO B . n 
B 1 599 LEU 599 599 599 LEU LEU B . n 
B 1 600 GLU 600 600 600 GLU GLU B . n 
B 1 601 VAL 601 601 601 VAL VAL B . n 
B 1 602 PHE 602 602 602 PHE PHE B . n 
B 1 603 ARG 603 603 603 ARG ARG B . n 
B 1 604 ARG 604 604 604 ARG ARG B . n 
B 1 605 PHE 605 605 605 PHE PHE B . n 
B 1 606 VAL 606 606 606 VAL VAL B . n 
B 1 607 TRP 607 607 607 TRP TRP B . n 
B 1 608 ASN 608 608 608 ASN ASN B . n 
B 1 609 PHE 609 609 609 PHE PHE B . n 
B 1 610 PHE 610 610 610 PHE PHE B . n 
B 1 611 ARG 611 611 611 ARG ARG B . n 
B 1 612 LEU 612 612 612 LEU LEU B . n 
B 1 613 GLU 613 613 613 GLU GLU B . n 
B 1 614 ASN 614 614 614 ASN ASN B . n 
B 1 615 GLU 615 615 615 GLU GLU B . n 
B 1 616 HIS 616 616 616 HIS HIS B . n 
B 1 617 LEU 617 617 617 LEU LEU B . n 
B 1 618 ASN 618 618 618 ASN ASN B . n 
B 1 619 ASN 619 619 619 ASN ASN B . n 
B 1 620 CYS 620 620 620 CYS CYS B . n 
B 1 621 GLY 621 621 621 GLY GLY B . n 
B 1 622 GLU 622 622 622 GLU GLU B . n 
B 1 623 PHE 623 623 623 PHE PHE B . n 
B 1 624 ARG 624 624 624 ARG ARG B . n 
B 1 625 ALA 625 625 ?   ?   ?   B . n 
B 1 626 VAL 626 626 ?   ?   ?   B . n 
B 1 627 ARG 627 627 ?   ?   ?   B . n 
B 1 628 ASP 628 628 ?   ?   ?   B . n 
B 1 629 ILE 629 629 ?   ?   ?   B . n 
B 1 630 SER 630 630 ?   ?   ?   B . n 
B 1 631 VAL 631 631 ?   ?   ?   B . n 
B 1 632 ALA 632 632 ?   ?   ?   B . n 
B 1 633 PRO 633 633 ?   ?   ?   B . n 
B 1 634 LEU 634 634 ?   ?   ?   B . n 
B 1 635 ASN 635 635 ?   ?   ?   B . n 
B 1 636 ALA 636 636 ?   ?   ?   B . n 
B 1 637 ASP 637 637 ?   ?   ?   B . n 
B 1 638 ASP 638 638 ?   ?   ?   B . n 
B 1 639 GLN 639 639 ?   ?   ?   B . n 
B 1 640 THR 640 640 ?   ?   ?   B . n 
B 1 641 LEU 641 641 ?   ?   ?   B . n 
B 1 642 LEU 642 642 ?   ?   ?   B . n 
B 1 643 GLU 643 643 ?   ?   ?   B . n 
B 1 644 GLN 644 644 ?   ?   ?   B . n 
B 1 645 MET 645 645 ?   ?   ?   B . n 
B 1 646 MET 646 646 ?   ?   ?   B . n 
B 1 647 ASP 647 647 ?   ?   ?   B . n 
B 1 648 GLN 648 648 ?   ?   ?   B . n 
B 1 649 ASP 649 649 ?   ?   ?   B . n 
B 1 650 ASP 650 650 ?   ?   ?   B . n 
B 1 651 GLY 651 651 ?   ?   ?   B . n 
B 1 652 VAL 652 652 ?   ?   ?   B . n 
B 1 653 ARG 653 653 ?   ?   ?   B . n 
B 1 654 ASN 654 654 ?   ?   ?   B . n 
B 1 655 ARG 655 655 ?   ?   ?   B . n 
B 1 656 GLN 656 656 ?   ?   ?   B . n 
B 1 657 LYS 657 657 ?   ?   ?   B . n 
B 1 658 ASN 658 658 ?   ?   ?   B . n 
B 1 659 ARG 659 659 ?   ?   ?   B . n 
B 1 660 SER 660 660 ?   ?   ?   B . n 
B 1 661 TRP 661 661 ?   ?   ?   B . n 
B 1 662 LYS 662 662 ?   ?   ?   B . n 
B 1 663 TYR 663 663 ?   ?   ?   B . n 
B 1 664 ASN 664 664 ?   ?   ?   B . n 
B 1 665 GLN 665 665 ?   ?   ?   B . n 
B 1 666 SER 666 666 ?   ?   ?   B . n 
B 1 667 ILE 667 667 ?   ?   ?   B . n 
B 1 668 SER 668 668 ?   ?   ?   B . n 
B 1 669 LEU 669 669 ?   ?   ?   B . n 
B 1 670 ARG 670 670 ?   ?   ?   B . n 
B 1 671 ARG 671 671 ?   ?   ?   B . n 
B 1 672 PRO 672 672 ?   ?   ?   B . n 
B 1 673 ARG 673 673 ?   ?   ?   B . n 
B 1 674 LEU 674 674 ?   ?   ?   B . n 
B 1 675 ALA 675 675 ?   ?   ?   B . n 
B 1 676 SER 676 676 ?   ?   ?   B . n 
B 1 677 GLN 677 677 ?   ?   ?   B . n 
B 1 678 SER 678 678 ?   ?   ?   B . n 
B 1 679 LYS 679 679 ?   ?   ?   B . n 
B 1 680 ALA 680 680 ?   ?   ?   B . n 
B 1 681 ARG 681 681 ?   ?   ?   B . n 
B 1 682 ASP 682 682 ?   ?   ?   B . n 
B 1 683 THR 683 683 ?   ?   ?   B . n 
B 1 684 LYS 684 684 ?   ?   ?   B . n 
B 1 685 VAL 685 685 ?   ?   ?   B . n 
B 1 686 LEU 686 686 ?   ?   ?   B . n 
B 1 687 ILE 687 687 ?   ?   ?   B . n 
B 1 688 GLU 688 688 ?   ?   ?   B . n 
B 1 689 ASP 689 689 ?   ?   ?   B . n 
B 1 690 THR 690 690 ?   ?   ?   B . n 
B 1 691 ASP 691 691 ?   ?   ?   B . n 
B 1 692 ASP 692 692 ?   ?   ?   B . n 
B 1 693 GLU 693 693 ?   ?   ?   B . n 
B 1 694 ALA 694 694 ?   ?   ?   B . n 
B 1 695 ASN 695 695 ?   ?   ?   B . n 
B 1 696 THR 696 696 ?   ?   ?   B . n 
B 1 697 LEU 697 697 ?   ?   ?   B . n 
B 1 698 GLU 698 698 ?   ?   ?   B . n 
B 1 699 ASP 699 699 ?   ?   ?   B . n 
B 1 700 TYR 700 700 ?   ?   ?   B . n 
B 1 701 LYS 701 701 ?   ?   ?   B . n 
B 1 702 ASP 702 702 ?   ?   ?   B . n 
B 1 703 HIS 703 703 ?   ?   ?   B . n 
B 1 704 ASP 704 704 ?   ?   ?   B . n 
B 1 705 GLY 705 705 ?   ?   ?   B . n 
B 1 706 ASP 706 706 ?   ?   ?   B . n 
B 1 707 TYR 707 707 ?   ?   ?   B . n 
B 1 708 LYS 708 708 ?   ?   ?   B . n 
B 1 709 ASP 709 709 ?   ?   ?   B . n 
B 1 710 HIS 710 710 ?   ?   ?   B . n 
B 1 711 ASP 711 711 ?   ?   ?   B . n 
B 1 712 ILE 712 712 ?   ?   ?   B . n 
B 1 713 ASP 713 713 ?   ?   ?   B . n 
B 1 714 TYR 714 714 ?   ?   ?   B . n 
B 1 715 LYS 715 715 ?   ?   ?   B . n 
B 1 716 ASP 716 716 ?   ?   ?   B . n 
B 1 717 ASP 717 717 ?   ?   ?   B . n 
B 1 718 ASP 718 718 ?   ?   ?   B . n 
B 1 719 ASP 719 719 ?   ?   ?   B . n 
B 1 720 LYS 720 720 ?   ?   ?   B . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 PC1 1 801 702 PC1 PC1 A . 
D 2 PC1 1 802 703 PC1 PC1 A . 
E 2 PC1 1 801 702 PC1 PC1 B . 
F 2 PC1 1 802 703 PC1 PC1 B . 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9J4X 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9J4X 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9J4X 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.entry_id                                 9J4X 
_refine.pdbx_diffrn_id                           ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             ? 
_refine.ls_d_res_high                            . 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.B_iso_mean                               ? 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.details                                  ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.overall_SU_ML                            ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.003  ? 6798 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 0.491  ? 9206 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 13.116 ? 2468 ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.039  ? 986  ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.004  ? 1100 ? f_plane_restr      ? ? 
# 
_struct.entry_id                     9J4X 
_struct.title                        'CryoEM structure of human XPR1 in apo state' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9J4X 
_struct_keywords.text            'Phosphate, Transport, XPR1, TRANSPORT PROTEIN' 
_struct_keywords.pdbx_keywords   'TRANSPORT PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 2 ? 
E N N 2 ? 
F N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    S53A1_HUMAN 
_struct_ref.pdbx_db_accession          Q9UBH6 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MKFAEHLSAHITPEWRKQYIQYEAFKDMLYSAQDQAPSVEVTDEDTVKRYFAKFEEKFFQTCEKELAKINTFYSEKLAEA
QRRFATLQNELQSSLDAQKESTGVTTLRQRRKPVFHLSHEERVQHRNIKDLKLAFSEFYLSLILLQNYQNLNFTGFRKIL
KKHDKILETSRGADWRVAHVEVAPFYTCKKINQLISETEAVVTNELEDGDRQKAMKRLRVPPLGAAQPAPAWTTFRVGLF
CGIFIVLNITLVLAAVFKLETDRSIWPLIRIYRGGFLLIEFLFLLGINTYGWRQAGVNHVLIFELNPRSNLSHQHLFEIA
GFLGILWCLSLLACFFAPISVIPTYVYPLALYGFMVFFLINPTKTFYYKSRFWLLKLLFRVFTAPFHKVGFADFWLADQL
NSLSVILMDLEYMICFYSLELKWDESKGLLPNNSEESGICHKYTYGVRAIVQCIPAWLRFIQCLRRYRDTKRAFPHLVNA
GKYSTTFFMVTFAALYSTHKERGHSDTMVFFYLWIVFYIISSCYTLIWDLKMDWGLFDKNAGENTFLREEIVYPQKAYYY
CAIIEDVILRFAWTIQISITSTTLLPHSGDIIATVFAPLEVFRRFVWNFFRLENEHLNNCGEFRAVRDISVAPLNADDQT
LLEQMMDQDDGVRNRQKNRSWKYNQSISLRRPRLASQSKARDTKVLIEDTDDEANT
;
_struct_ref.pdbx_align_begin           1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9J4X A 1 ? 696 ? Q9UBH6 1 ? 696 ? 1 696 
2 1 9J4X B 1 ? 696 ? Q9UBH6 1 ? 696 ? 1 696 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9J4X LEU A 697 ? UNP Q9UBH6 ? ? 'expression tag' 697 1  
1 9J4X GLU A 698 ? UNP Q9UBH6 ? ? 'expression tag' 698 2  
1 9J4X ASP A 699 ? UNP Q9UBH6 ? ? 'expression tag' 699 3  
1 9J4X TYR A 700 ? UNP Q9UBH6 ? ? 'expression tag' 700 4  
1 9J4X LYS A 701 ? UNP Q9UBH6 ? ? 'expression tag' 701 5  
1 9J4X ASP A 702 ? UNP Q9UBH6 ? ? 'expression tag' 702 6  
1 9J4X HIS A 703 ? UNP Q9UBH6 ? ? 'expression tag' 703 7  
1 9J4X ASP A 704 ? UNP Q9UBH6 ? ? 'expression tag' 704 8  
1 9J4X GLY A 705 ? UNP Q9UBH6 ? ? 'expression tag' 705 9  
1 9J4X ASP A 706 ? UNP Q9UBH6 ? ? 'expression tag' 706 10 
1 9J4X TYR A 707 ? UNP Q9UBH6 ? ? 'expression tag' 707 11 
1 9J4X LYS A 708 ? UNP Q9UBH6 ? ? 'expression tag' 708 12 
1 9J4X ASP A 709 ? UNP Q9UBH6 ? ? 'expression tag' 709 13 
1 9J4X HIS A 710 ? UNP Q9UBH6 ? ? 'expression tag' 710 14 
1 9J4X ASP A 711 ? UNP Q9UBH6 ? ? 'expression tag' 711 15 
1 9J4X ILE A 712 ? UNP Q9UBH6 ? ? 'expression tag' 712 16 
1 9J4X ASP A 713 ? UNP Q9UBH6 ? ? 'expression tag' 713 17 
1 9J4X TYR A 714 ? UNP Q9UBH6 ? ? 'expression tag' 714 18 
1 9J4X LYS A 715 ? UNP Q9UBH6 ? ? 'expression tag' 715 19 
1 9J4X ASP A 716 ? UNP Q9UBH6 ? ? 'expression tag' 716 20 
1 9J4X ASP A 717 ? UNP Q9UBH6 ? ? 'expression tag' 717 21 
1 9J4X ASP A 718 ? UNP Q9UBH6 ? ? 'expression tag' 718 22 
1 9J4X ASP A 719 ? UNP Q9UBH6 ? ? 'expression tag' 719 23 
1 9J4X LYS A 720 ? UNP Q9UBH6 ? ? 'expression tag' 720 24 
2 9J4X LEU B 697 ? UNP Q9UBH6 ? ? 'expression tag' 697 25 
2 9J4X GLU B 698 ? UNP Q9UBH6 ? ? 'expression tag' 698 26 
2 9J4X ASP B 699 ? UNP Q9UBH6 ? ? 'expression tag' 699 27 
2 9J4X TYR B 700 ? UNP Q9UBH6 ? ? 'expression tag' 700 28 
2 9J4X LYS B 701 ? UNP Q9UBH6 ? ? 'expression tag' 701 29 
2 9J4X ASP B 702 ? UNP Q9UBH6 ? ? 'expression tag' 702 30 
2 9J4X HIS B 703 ? UNP Q9UBH6 ? ? 'expression tag' 703 31 
2 9J4X ASP B 704 ? UNP Q9UBH6 ? ? 'expression tag' 704 32 
2 9J4X GLY B 705 ? UNP Q9UBH6 ? ? 'expression tag' 705 33 
2 9J4X ASP B 706 ? UNP Q9UBH6 ? ? 'expression tag' 706 34 
2 9J4X TYR B 707 ? UNP Q9UBH6 ? ? 'expression tag' 707 35 
2 9J4X LYS B 708 ? UNP Q9UBH6 ? ? 'expression tag' 708 36 
2 9J4X ASP B 709 ? UNP Q9UBH6 ? ? 'expression tag' 709 37 
2 9J4X HIS B 710 ? UNP Q9UBH6 ? ? 'expression tag' 710 38 
2 9J4X ASP B 711 ? UNP Q9UBH6 ? ? 'expression tag' 711 39 
2 9J4X ILE B 712 ? UNP Q9UBH6 ? ? 'expression tag' 712 40 
2 9J4X ASP B 713 ? UNP Q9UBH6 ? ? 'expression tag' 713 41 
2 9J4X TYR B 714 ? UNP Q9UBH6 ? ? 'expression tag' 714 42 
2 9J4X LYS B 715 ? UNP Q9UBH6 ? ? 'expression tag' 715 43 
2 9J4X ASP B 716 ? UNP Q9UBH6 ? ? 'expression tag' 716 44 
2 9J4X ASP B 717 ? UNP Q9UBH6 ? ? 'expression tag' 717 45 
2 9J4X ASP B 718 ? UNP Q9UBH6 ? ? 'expression tag' 718 46 
2 9J4X ASP B 719 ? UNP Q9UBH6 ? ? 'expression tag' 719 47 
2 9J4X LYS B 720 ? UNP Q9UBH6 ? ? 'expression tag' 720 48 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 PRO A 230 ? LYS A 258 ? PRO A 230 LYS A 258 1 ? 29 
HELX_P HELX_P2  AA2 PRO A 267 ? GLY A 296 ? PRO A 267 GLY A 296 1 ? 30 
HELX_P HELX_P3  AA3 ASN A 298 ? PHE A 303 ? ASN A 298 PHE A 303 1 ? 6  
HELX_P HELX_P4  AA4 SER A 312 ? PHE A 336 ? SER A 312 PHE A 336 1 ? 25 
HELX_P HELX_P5  AA5 ALA A 337 ? SER A 340 ? ALA A 337 SER A 340 5 ? 4  
HELX_P HELX_P6  AA6 TYR A 345 ? ILE A 360 ? TYR A 345 ILE A 360 1 ? 16 
HELX_P HELX_P7  AA7 TYR A 367 ? THR A 383 ? TYR A 367 THR A 383 1 ? 17 
HELX_P HELX_P8  AA8 GLY A 390 ? LEU A 403 ? GLY A 390 LEU A 403 1 ? 14 
HELX_P HELX_P9  AA9 LEU A 403 ? GLU A 420 ? LEU A 403 GLU A 420 1 ? 18 
HELX_P HELX_P10 AB1 VAL A 447 ? CYS A 453 ? VAL A 447 CYS A 453 1 ? 7  
HELX_P HELX_P11 AB2 CYS A 453 ? LYS A 471 ? CYS A 453 LYS A 471 1 ? 19 
HELX_P HELX_P12 AB3 ARG A 472 ? GLY A 503 ? ARG A 472 GLY A 503 1 ? 32 
HELX_P HELX_P13 AB4 ASP A 506 ? MET A 532 ? ASP A 506 MET A 532 1 ? 27 
HELX_P HELX_P14 AB5 LYS A 556 ? THR A 582 ? LYS A 556 THR A 582 1 ? 27 
HELX_P HELX_P15 AB6 GLY A 589 ? ASN A 618 ? GLY A 589 ASN A 618 1 ? 30 
HELX_P HELX_P16 AB7 ASN A 619 ? PHE A 623 ? ASN A 619 PHE A 623 5 ? 5  
HELX_P HELX_P17 AB8 PRO B 230 ? PHE B 257 ? PRO B 230 PHE B 257 1 ? 28 
HELX_P HELX_P18 AB9 ILE B 265 ? GLY B 296 ? ILE B 265 GLY B 296 1 ? 32 
HELX_P HELX_P19 AC1 ASN B 298 ? PHE B 303 ? ASN B 298 PHE B 303 1 ? 6  
HELX_P HELX_P20 AC2 SER B 312 ? PHE B 336 ? SER B 312 PHE B 336 1 ? 25 
HELX_P HELX_P21 AC3 TYR B 345 ? ILE B 360 ? TYR B 345 ILE B 360 1 ? 16 
HELX_P HELX_P22 AC4 TYR B 367 ? THR B 383 ? TYR B 367 THR B 383 1 ? 17 
HELX_P HELX_P23 AC5 ALA B 384 ? HIS B 387 ? ALA B 384 HIS B 387 5 ? 4  
HELX_P HELX_P24 AC6 GLY B 390 ? TYR B 417 ? GLY B 390 TYR B 417 1 ? 28 
HELX_P HELX_P25 AC7 VAL B 447 ? CYS B 453 ? VAL B 447 CYS B 453 1 ? 7  
HELX_P HELX_P26 AC8 CYS B 453 ? LYS B 471 ? CYS B 453 LYS B 471 1 ? 19 
HELX_P HELX_P27 AC9 ARG B 472 ? HIS B 499 ? ARG B 472 HIS B 499 1 ? 28 
HELX_P HELX_P28 AD1 ASP B 506 ? MET B 532 ? ASP B 506 MET B 532 1 ? 27 
HELX_P HELX_P29 AD2 LYS B 556 ? SER B 581 ? LYS B 556 SER B 581 1 ? 26 
HELX_P HELX_P30 AD3 GLY B 589 ? ASN B 619 ? GLY B 589 ASN B 619 1 ? 31 
HELX_P HELX_P31 AD4 CYS B 620 ? PHE B 623 ? CYS B 620 PHE B 623 5 ? 4  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          PHE 
_struct_mon_prot_cis.label_seq_id           474 
_struct_mon_prot_cis.label_asym_id          B 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           PHE 
_struct_mon_prot_cis.auth_seq_id            474 
_struct_mon_prot_cis.auth_asym_id           B 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    475 
_struct_mon_prot_cis.pdbx_label_asym_id_2   B 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     475 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    B 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       -0.92 
# 
_pdbx_entry_details.entry_id                   9J4X 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   O 
_pdbx_validate_close_contact.auth_asym_id_1   A 
_pdbx_validate_close_contact.auth_comp_id_1   ILE 
_pdbx_validate_close_contact.auth_seq_id_1    271 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   OH 
_pdbx_validate_close_contact.auth_asym_id_2   A 
_pdbx_validate_close_contact.auth_comp_id_2   TYR 
_pdbx_validate_close_contact.auth_seq_id_2    352 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.14 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 LEU A 259 ? ? -93.09  -72.58  
2  1 GLU A 260 ? ? -143.57 -26.89  
3  1 THR A 261 ? ? 69.76   -9.66   
4  1 ASP A 262 ? ? -141.55 -17.86  
5  1 ARG A 263 ? ? -84.00  -70.15  
6  1 SER A 264 ? ? 177.62  163.59  
7  1 ARG A 270 ? ? -140.66 -24.89  
8  1 PRO A 338 ? ? -65.27  5.83    
9  1 TRP A 423 ? ? 68.62   -3.91   
10 1 PHE A 546 ? ? 67.45   -3.47   
11 1 SER A 588 ? ? 57.73   -138.92 
12 1 LEU B 259 ? ? 69.01   -178.41 
13 1 LYS B 500 ? ? 67.39   -4.21   
14 1 PHE B 546 ? ? 68.33   -0.10   
15 1 SER B 588 ? ? 56.63   -137.15 
# 
_pdbx_validate_peptide_omega.id               1 
_pdbx_validate_peptide_omega.PDB_model_num    1 
_pdbx_validate_peptide_omega.auth_comp_id_1   ILE 
_pdbx_validate_peptide_omega.auth_asym_id_1   A 
_pdbx_validate_peptide_omega.auth_seq_id_1    269 
_pdbx_validate_peptide_omega.PDB_ins_code_1   ? 
_pdbx_validate_peptide_omega.label_alt_id_1   ? 
_pdbx_validate_peptide_omega.auth_comp_id_2   ARG 
_pdbx_validate_peptide_omega.auth_asym_id_2   A 
_pdbx_validate_peptide_omega.auth_seq_id_2    270 
_pdbx_validate_peptide_omega.PDB_ins_code_2   ? 
_pdbx_validate_peptide_omega.label_alt_id_2   ? 
_pdbx_validate_peptide_omega.omega            148.18 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9J4X 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    9J4X 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  2.9 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               174844 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            8 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'Human XPR1' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        9J4X 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             1200 
_em_imaging.nominal_defocus_max             2200 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              9J4X 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9J4X 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
_em_single_particle_entity.entry_id              9J4X 
_em_single_particle_entity.id                    1 
_em_single_particle_entity.image_processing_id   1 
_em_single_particle_entity.point_symmetry        C1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A MET 1   ? A MET 1   
2   1 Y 1 A LYS 2   ? A LYS 2   
3   1 Y 1 A PHE 3   ? A PHE 3   
4   1 Y 1 A ALA 4   ? A ALA 4   
5   1 Y 1 A GLU 5   ? A GLU 5   
6   1 Y 1 A HIS 6   ? A HIS 6   
7   1 Y 1 A LEU 7   ? A LEU 7   
8   1 Y 1 A SER 8   ? A SER 8   
9   1 Y 1 A ALA 9   ? A ALA 9   
10  1 Y 1 A HIS 10  ? A HIS 10  
11  1 Y 1 A ILE 11  ? A ILE 11  
12  1 Y 1 A THR 12  ? A THR 12  
13  1 Y 1 A PRO 13  ? A PRO 13  
14  1 Y 1 A GLU 14  ? A GLU 14  
15  1 Y 1 A TRP 15  ? A TRP 15  
16  1 Y 1 A ARG 16  ? A ARG 16  
17  1 Y 1 A LYS 17  ? A LYS 17  
18  1 Y 1 A GLN 18  ? A GLN 18  
19  1 Y 1 A TYR 19  ? A TYR 19  
20  1 Y 1 A ILE 20  ? A ILE 20  
21  1 Y 1 A GLN 21  ? A GLN 21  
22  1 Y 1 A TYR 22  ? A TYR 22  
23  1 Y 1 A GLU 23  ? A GLU 23  
24  1 Y 1 A ALA 24  ? A ALA 24  
25  1 Y 1 A PHE 25  ? A PHE 25  
26  1 Y 1 A LYS 26  ? A LYS 26  
27  1 Y 1 A ASP 27  ? A ASP 27  
28  1 Y 1 A MET 28  ? A MET 28  
29  1 Y 1 A LEU 29  ? A LEU 29  
30  1 Y 1 A TYR 30  ? A TYR 30  
31  1 Y 1 A SER 31  ? A SER 31  
32  1 Y 1 A ALA 32  ? A ALA 32  
33  1 Y 1 A GLN 33  ? A GLN 33  
34  1 Y 1 A ASP 34  ? A ASP 34  
35  1 Y 1 A GLN 35  ? A GLN 35  
36  1 Y 1 A ALA 36  ? A ALA 36  
37  1 Y 1 A PRO 37  ? A PRO 37  
38  1 Y 1 A SER 38  ? A SER 38  
39  1 Y 1 A VAL 39  ? A VAL 39  
40  1 Y 1 A GLU 40  ? A GLU 40  
41  1 Y 1 A VAL 41  ? A VAL 41  
42  1 Y 1 A THR 42  ? A THR 42  
43  1 Y 1 A ASP 43  ? A ASP 43  
44  1 Y 1 A GLU 44  ? A GLU 44  
45  1 Y 1 A ASP 45  ? A ASP 45  
46  1 Y 1 A THR 46  ? A THR 46  
47  1 Y 1 A VAL 47  ? A VAL 47  
48  1 Y 1 A LYS 48  ? A LYS 48  
49  1 Y 1 A ARG 49  ? A ARG 49  
50  1 Y 1 A TYR 50  ? A TYR 50  
51  1 Y 1 A PHE 51  ? A PHE 51  
52  1 Y 1 A ALA 52  ? A ALA 52  
53  1 Y 1 A LYS 53  ? A LYS 53  
54  1 Y 1 A PHE 54  ? A PHE 54  
55  1 Y 1 A GLU 55  ? A GLU 55  
56  1 Y 1 A GLU 56  ? A GLU 56  
57  1 Y 1 A LYS 57  ? A LYS 57  
58  1 Y 1 A PHE 58  ? A PHE 58  
59  1 Y 1 A PHE 59  ? A PHE 59  
60  1 Y 1 A GLN 60  ? A GLN 60  
61  1 Y 1 A THR 61  ? A THR 61  
62  1 Y 1 A CYS 62  ? A CYS 62  
63  1 Y 1 A GLU 63  ? A GLU 63  
64  1 Y 1 A LYS 64  ? A LYS 64  
65  1 Y 1 A GLU 65  ? A GLU 65  
66  1 Y 1 A LEU 66  ? A LEU 66  
67  1 Y 1 A ALA 67  ? A ALA 67  
68  1 Y 1 A LYS 68  ? A LYS 68  
69  1 Y 1 A ILE 69  ? A ILE 69  
70  1 Y 1 A ASN 70  ? A ASN 70  
71  1 Y 1 A THR 71  ? A THR 71  
72  1 Y 1 A PHE 72  ? A PHE 72  
73  1 Y 1 A TYR 73  ? A TYR 73  
74  1 Y 1 A SER 74  ? A SER 74  
75  1 Y 1 A GLU 75  ? A GLU 75  
76  1 Y 1 A LYS 76  ? A LYS 76  
77  1 Y 1 A LEU 77  ? A LEU 77  
78  1 Y 1 A ALA 78  ? A ALA 78  
79  1 Y 1 A GLU 79  ? A GLU 79  
80  1 Y 1 A ALA 80  ? A ALA 80  
81  1 Y 1 A GLN 81  ? A GLN 81  
82  1 Y 1 A ARG 82  ? A ARG 82  
83  1 Y 1 A ARG 83  ? A ARG 83  
84  1 Y 1 A PHE 84  ? A PHE 84  
85  1 Y 1 A ALA 85  ? A ALA 85  
86  1 Y 1 A THR 86  ? A THR 86  
87  1 Y 1 A LEU 87  ? A LEU 87  
88  1 Y 1 A GLN 88  ? A GLN 88  
89  1 Y 1 A ASN 89  ? A ASN 89  
90  1 Y 1 A GLU 90  ? A GLU 90  
91  1 Y 1 A LEU 91  ? A LEU 91  
92  1 Y 1 A GLN 92  ? A GLN 92  
93  1 Y 1 A SER 93  ? A SER 93  
94  1 Y 1 A SER 94  ? A SER 94  
95  1 Y 1 A LEU 95  ? A LEU 95  
96  1 Y 1 A ASP 96  ? A ASP 96  
97  1 Y 1 A ALA 97  ? A ALA 97  
98  1 Y 1 A GLN 98  ? A GLN 98  
99  1 Y 1 A LYS 99  ? A LYS 99  
100 1 Y 1 A GLU 100 ? A GLU 100 
101 1 Y 1 A SER 101 ? A SER 101 
102 1 Y 1 A THR 102 ? A THR 102 
103 1 Y 1 A GLY 103 ? A GLY 103 
104 1 Y 1 A VAL 104 ? A VAL 104 
105 1 Y 1 A THR 105 ? A THR 105 
106 1 Y 1 A THR 106 ? A THR 106 
107 1 Y 1 A LEU 107 ? A LEU 107 
108 1 Y 1 A ARG 108 ? A ARG 108 
109 1 Y 1 A GLN 109 ? A GLN 109 
110 1 Y 1 A ARG 110 ? A ARG 110 
111 1 Y 1 A ARG 111 ? A ARG 111 
112 1 Y 1 A LYS 112 ? A LYS 112 
113 1 Y 1 A PRO 113 ? A PRO 113 
114 1 Y 1 A VAL 114 ? A VAL 114 
115 1 Y 1 A PHE 115 ? A PHE 115 
116 1 Y 1 A HIS 116 ? A HIS 116 
117 1 Y 1 A LEU 117 ? A LEU 117 
118 1 Y 1 A SER 118 ? A SER 118 
119 1 Y 1 A HIS 119 ? A HIS 119 
120 1 Y 1 A GLU 120 ? A GLU 120 
121 1 Y 1 A GLU 121 ? A GLU 121 
122 1 Y 1 A ARG 122 ? A ARG 122 
123 1 Y 1 A VAL 123 ? A VAL 123 
124 1 Y 1 A GLN 124 ? A GLN 124 
125 1 Y 1 A HIS 125 ? A HIS 125 
126 1 Y 1 A ARG 126 ? A ARG 126 
127 1 Y 1 A ASN 127 ? A ASN 127 
128 1 Y 1 A ILE 128 ? A ILE 128 
129 1 Y 1 A LYS 129 ? A LYS 129 
130 1 Y 1 A ASP 130 ? A ASP 130 
131 1 Y 1 A LEU 131 ? A LEU 131 
132 1 Y 1 A LYS 132 ? A LYS 132 
133 1 Y 1 A LEU 133 ? A LEU 133 
134 1 Y 1 A ALA 134 ? A ALA 134 
135 1 Y 1 A PHE 135 ? A PHE 135 
136 1 Y 1 A SER 136 ? A SER 136 
137 1 Y 1 A GLU 137 ? A GLU 137 
138 1 Y 1 A PHE 138 ? A PHE 138 
139 1 Y 1 A TYR 139 ? A TYR 139 
140 1 Y 1 A LEU 140 ? A LEU 140 
141 1 Y 1 A SER 141 ? A SER 141 
142 1 Y 1 A LEU 142 ? A LEU 142 
143 1 Y 1 A ILE 143 ? A ILE 143 
144 1 Y 1 A LEU 144 ? A LEU 144 
145 1 Y 1 A LEU 145 ? A LEU 145 
146 1 Y 1 A GLN 146 ? A GLN 146 
147 1 Y 1 A ASN 147 ? A ASN 147 
148 1 Y 1 A TYR 148 ? A TYR 148 
149 1 Y 1 A GLN 149 ? A GLN 149 
150 1 Y 1 A ASN 150 ? A ASN 150 
151 1 Y 1 A LEU 151 ? A LEU 151 
152 1 Y 1 A ASN 152 ? A ASN 152 
153 1 Y 1 A PHE 153 ? A PHE 153 
154 1 Y 1 A THR 154 ? A THR 154 
155 1 Y 1 A GLY 155 ? A GLY 155 
156 1 Y 1 A PHE 156 ? A PHE 156 
157 1 Y 1 A ARG 157 ? A ARG 157 
158 1 Y 1 A LYS 158 ? A LYS 158 
159 1 Y 1 A ILE 159 ? A ILE 159 
160 1 Y 1 A LEU 160 ? A LEU 160 
161 1 Y 1 A LYS 161 ? A LYS 161 
162 1 Y 1 A LYS 162 ? A LYS 162 
163 1 Y 1 A HIS 163 ? A HIS 163 
164 1 Y 1 A ASP 164 ? A ASP 164 
165 1 Y 1 A LYS 165 ? A LYS 165 
166 1 Y 1 A ILE 166 ? A ILE 166 
167 1 Y 1 A LEU 167 ? A LEU 167 
168 1 Y 1 A GLU 168 ? A GLU 168 
169 1 Y 1 A THR 169 ? A THR 169 
170 1 Y 1 A SER 170 ? A SER 170 
171 1 Y 1 A ARG 171 ? A ARG 171 
172 1 Y 1 A GLY 172 ? A GLY 172 
173 1 Y 1 A ALA 173 ? A ALA 173 
174 1 Y 1 A ASP 174 ? A ASP 174 
175 1 Y 1 A TRP 175 ? A TRP 175 
176 1 Y 1 A ARG 176 ? A ARG 176 
177 1 Y 1 A VAL 177 ? A VAL 177 
178 1 Y 1 A ALA 178 ? A ALA 178 
179 1 Y 1 A HIS 179 ? A HIS 179 
180 1 Y 1 A VAL 180 ? A VAL 180 
181 1 Y 1 A GLU 181 ? A GLU 181 
182 1 Y 1 A VAL 182 ? A VAL 182 
183 1 Y 1 A ALA 183 ? A ALA 183 
184 1 Y 1 A PRO 184 ? A PRO 184 
185 1 Y 1 A PHE 185 ? A PHE 185 
186 1 Y 1 A TYR 186 ? A TYR 186 
187 1 Y 1 A THR 187 ? A THR 187 
188 1 Y 1 A CYS 188 ? A CYS 188 
189 1 Y 1 A LYS 189 ? A LYS 189 
190 1 Y 1 A LYS 190 ? A LYS 190 
191 1 Y 1 A ILE 191 ? A ILE 191 
192 1 Y 1 A ASN 192 ? A ASN 192 
193 1 Y 1 A GLN 193 ? A GLN 193 
194 1 Y 1 A LEU 194 ? A LEU 194 
195 1 Y 1 A ILE 195 ? A ILE 195 
196 1 Y 1 A SER 196 ? A SER 196 
197 1 Y 1 A GLU 197 ? A GLU 197 
198 1 Y 1 A THR 198 ? A THR 198 
199 1 Y 1 A GLU 199 ? A GLU 199 
200 1 Y 1 A ALA 200 ? A ALA 200 
201 1 Y 1 A VAL 201 ? A VAL 201 
202 1 Y 1 A VAL 202 ? A VAL 202 
203 1 Y 1 A THR 203 ? A THR 203 
204 1 Y 1 A ASN 204 ? A ASN 204 
205 1 Y 1 A GLU 205 ? A GLU 205 
206 1 Y 1 A LEU 206 ? A LEU 206 
207 1 Y 1 A GLU 207 ? A GLU 207 
208 1 Y 1 A ASP 208 ? A ASP 208 
209 1 Y 1 A GLY 209 ? A GLY 209 
210 1 Y 1 A ASP 210 ? A ASP 210 
211 1 Y 1 A ARG 211 ? A ARG 211 
212 1 Y 1 A GLN 212 ? A GLN 212 
213 1 Y 1 A LYS 213 ? A LYS 213 
214 1 Y 1 A ALA 214 ? A ALA 214 
215 1 Y 1 A MET 215 ? A MET 215 
216 1 Y 1 A LYS 216 ? A LYS 216 
217 1 Y 1 A ARG 217 ? A ARG 217 
218 1 Y 1 A LEU 218 ? A LEU 218 
219 1 Y 1 A ARG 219 ? A ARG 219 
220 1 Y 1 A VAL 220 ? A VAL 220 
221 1 Y 1 A PRO 221 ? A PRO 221 
222 1 Y 1 A PRO 222 ? A PRO 222 
223 1 Y 1 A LEU 223 ? A LEU 223 
224 1 Y 1 A GLY 224 ? A GLY 224 
225 1 Y 1 A ALA 225 ? A ALA 225 
226 1 Y 1 A ALA 226 ? A ALA 226 
227 1 Y 1 A GLN 227 ? A GLN 227 
228 1 Y 1 A PRO 228 ? A PRO 228 
229 1 Y 1 A ASN 432 ? A ASN 432 
230 1 Y 1 A ASN 433 ? A ASN 433 
231 1 Y 1 A SER 434 ? A SER 434 
232 1 Y 1 A GLU 435 ? A GLU 435 
233 1 Y 1 A GLU 436 ? A GLU 436 
234 1 Y 1 A SER 437 ? A SER 437 
235 1 Y 1 A GLY 438 ? A GLY 438 
236 1 Y 1 A ILE 439 ? A ILE 439 
237 1 Y 1 A CYS 440 ? A CYS 440 
238 1 Y 1 A HIS 441 ? A HIS 441 
239 1 Y 1 A LYS 442 ? A LYS 442 
240 1 Y 1 A TYR 443 ? A TYR 443 
241 1 Y 1 A THR 444 ? A THR 444 
242 1 Y 1 A TYR 445 ? A TYR 445 
243 1 Y 1 A ALA 625 ? A ALA 625 
244 1 Y 1 A VAL 626 ? A VAL 626 
245 1 Y 1 A ARG 627 ? A ARG 627 
246 1 Y 1 A ASP 628 ? A ASP 628 
247 1 Y 1 A ILE 629 ? A ILE 629 
248 1 Y 1 A SER 630 ? A SER 630 
249 1 Y 1 A VAL 631 ? A VAL 631 
250 1 Y 1 A ALA 632 ? A ALA 632 
251 1 Y 1 A PRO 633 ? A PRO 633 
252 1 Y 1 A LEU 634 ? A LEU 634 
253 1 Y 1 A ASN 635 ? A ASN 635 
254 1 Y 1 A ALA 636 ? A ALA 636 
255 1 Y 1 A ASP 637 ? A ASP 637 
256 1 Y 1 A ASP 638 ? A ASP 638 
257 1 Y 1 A GLN 639 ? A GLN 639 
258 1 Y 1 A THR 640 ? A THR 640 
259 1 Y 1 A LEU 641 ? A LEU 641 
260 1 Y 1 A LEU 642 ? A LEU 642 
261 1 Y 1 A GLU 643 ? A GLU 643 
262 1 Y 1 A GLN 644 ? A GLN 644 
263 1 Y 1 A MET 645 ? A MET 645 
264 1 Y 1 A MET 646 ? A MET 646 
265 1 Y 1 A ASP 647 ? A ASP 647 
266 1 Y 1 A GLN 648 ? A GLN 648 
267 1 Y 1 A ASP 649 ? A ASP 649 
268 1 Y 1 A ASP 650 ? A ASP 650 
269 1 Y 1 A GLY 651 ? A GLY 651 
270 1 Y 1 A VAL 652 ? A VAL 652 
271 1 Y 1 A ARG 653 ? A ARG 653 
272 1 Y 1 A ASN 654 ? A ASN 654 
273 1 Y 1 A ARG 655 ? A ARG 655 
274 1 Y 1 A GLN 656 ? A GLN 656 
275 1 Y 1 A LYS 657 ? A LYS 657 
276 1 Y 1 A ASN 658 ? A ASN 658 
277 1 Y 1 A ARG 659 ? A ARG 659 
278 1 Y 1 A SER 660 ? A SER 660 
279 1 Y 1 A TRP 661 ? A TRP 661 
280 1 Y 1 A LYS 662 ? A LYS 662 
281 1 Y 1 A TYR 663 ? A TYR 663 
282 1 Y 1 A ASN 664 ? A ASN 664 
283 1 Y 1 A GLN 665 ? A GLN 665 
284 1 Y 1 A SER 666 ? A SER 666 
285 1 Y 1 A ILE 667 ? A ILE 667 
286 1 Y 1 A SER 668 ? A SER 668 
287 1 Y 1 A LEU 669 ? A LEU 669 
288 1 Y 1 A ARG 670 ? A ARG 670 
289 1 Y 1 A ARG 671 ? A ARG 671 
290 1 Y 1 A PRO 672 ? A PRO 672 
291 1 Y 1 A ARG 673 ? A ARG 673 
292 1 Y 1 A LEU 674 ? A LEU 674 
293 1 Y 1 A ALA 675 ? A ALA 675 
294 1 Y 1 A SER 676 ? A SER 676 
295 1 Y 1 A GLN 677 ? A GLN 677 
296 1 Y 1 A SER 678 ? A SER 678 
297 1 Y 1 A LYS 679 ? A LYS 679 
298 1 Y 1 A ALA 680 ? A ALA 680 
299 1 Y 1 A ARG 681 ? A ARG 681 
300 1 Y 1 A ASP 682 ? A ASP 682 
301 1 Y 1 A THR 683 ? A THR 683 
302 1 Y 1 A LYS 684 ? A LYS 684 
303 1 Y 1 A VAL 685 ? A VAL 685 
304 1 Y 1 A LEU 686 ? A LEU 686 
305 1 Y 1 A ILE 687 ? A ILE 687 
306 1 Y 1 A GLU 688 ? A GLU 688 
307 1 Y 1 A ASP 689 ? A ASP 689 
308 1 Y 1 A THR 690 ? A THR 690 
309 1 Y 1 A ASP 691 ? A ASP 691 
310 1 Y 1 A ASP 692 ? A ASP 692 
311 1 Y 1 A GLU 693 ? A GLU 693 
312 1 Y 1 A ALA 694 ? A ALA 694 
313 1 Y 1 A ASN 695 ? A ASN 695 
314 1 Y 1 A THR 696 ? A THR 696 
315 1 Y 1 A LEU 697 ? A LEU 697 
316 1 Y 1 A GLU 698 ? A GLU 698 
317 1 Y 1 A ASP 699 ? A ASP 699 
318 1 Y 1 A TYR 700 ? A TYR 700 
319 1 Y 1 A LYS 701 ? A LYS 701 
320 1 Y 1 A ASP 702 ? A ASP 702 
321 1 Y 1 A HIS 703 ? A HIS 703 
322 1 Y 1 A ASP 704 ? A ASP 704 
323 1 Y 1 A GLY 705 ? A GLY 705 
324 1 Y 1 A ASP 706 ? A ASP 706 
325 1 Y 1 A TYR 707 ? A TYR 707 
326 1 Y 1 A LYS 708 ? A LYS 708 
327 1 Y 1 A ASP 709 ? A ASP 709 
328 1 Y 1 A HIS 710 ? A HIS 710 
329 1 Y 1 A ASP 711 ? A ASP 711 
330 1 Y 1 A ILE 712 ? A ILE 712 
331 1 Y 1 A ASP 713 ? A ASP 713 
332 1 Y 1 A TYR 714 ? A TYR 714 
333 1 Y 1 A LYS 715 ? A LYS 715 
334 1 Y 1 A ASP 716 ? A ASP 716 
335 1 Y 1 A ASP 717 ? A ASP 717 
336 1 Y 1 A ASP 718 ? A ASP 718 
337 1 Y 1 A ASP 719 ? A ASP 719 
338 1 Y 1 A LYS 720 ? A LYS 720 
339 1 Y 1 B MET 1   ? B MET 1   
340 1 Y 1 B LYS 2   ? B LYS 2   
341 1 Y 1 B PHE 3   ? B PHE 3   
342 1 Y 1 B ALA 4   ? B ALA 4   
343 1 Y 1 B GLU 5   ? B GLU 5   
344 1 Y 1 B HIS 6   ? B HIS 6   
345 1 Y 1 B LEU 7   ? B LEU 7   
346 1 Y 1 B SER 8   ? B SER 8   
347 1 Y 1 B ALA 9   ? B ALA 9   
348 1 Y 1 B HIS 10  ? B HIS 10  
349 1 Y 1 B ILE 11  ? B ILE 11  
350 1 Y 1 B THR 12  ? B THR 12  
351 1 Y 1 B PRO 13  ? B PRO 13  
352 1 Y 1 B GLU 14  ? B GLU 14  
353 1 Y 1 B TRP 15  ? B TRP 15  
354 1 Y 1 B ARG 16  ? B ARG 16  
355 1 Y 1 B LYS 17  ? B LYS 17  
356 1 Y 1 B GLN 18  ? B GLN 18  
357 1 Y 1 B TYR 19  ? B TYR 19  
358 1 Y 1 B ILE 20  ? B ILE 20  
359 1 Y 1 B GLN 21  ? B GLN 21  
360 1 Y 1 B TYR 22  ? B TYR 22  
361 1 Y 1 B GLU 23  ? B GLU 23  
362 1 Y 1 B ALA 24  ? B ALA 24  
363 1 Y 1 B PHE 25  ? B PHE 25  
364 1 Y 1 B LYS 26  ? B LYS 26  
365 1 Y 1 B ASP 27  ? B ASP 27  
366 1 Y 1 B MET 28  ? B MET 28  
367 1 Y 1 B LEU 29  ? B LEU 29  
368 1 Y 1 B TYR 30  ? B TYR 30  
369 1 Y 1 B SER 31  ? B SER 31  
370 1 Y 1 B ALA 32  ? B ALA 32  
371 1 Y 1 B GLN 33  ? B GLN 33  
372 1 Y 1 B ASP 34  ? B ASP 34  
373 1 Y 1 B GLN 35  ? B GLN 35  
374 1 Y 1 B ALA 36  ? B ALA 36  
375 1 Y 1 B PRO 37  ? B PRO 37  
376 1 Y 1 B SER 38  ? B SER 38  
377 1 Y 1 B VAL 39  ? B VAL 39  
378 1 Y 1 B GLU 40  ? B GLU 40  
379 1 Y 1 B VAL 41  ? B VAL 41  
380 1 Y 1 B THR 42  ? B THR 42  
381 1 Y 1 B ASP 43  ? B ASP 43  
382 1 Y 1 B GLU 44  ? B GLU 44  
383 1 Y 1 B ASP 45  ? B ASP 45  
384 1 Y 1 B THR 46  ? B THR 46  
385 1 Y 1 B VAL 47  ? B VAL 47  
386 1 Y 1 B LYS 48  ? B LYS 48  
387 1 Y 1 B ARG 49  ? B ARG 49  
388 1 Y 1 B TYR 50  ? B TYR 50  
389 1 Y 1 B PHE 51  ? B PHE 51  
390 1 Y 1 B ALA 52  ? B ALA 52  
391 1 Y 1 B LYS 53  ? B LYS 53  
392 1 Y 1 B PHE 54  ? B PHE 54  
393 1 Y 1 B GLU 55  ? B GLU 55  
394 1 Y 1 B GLU 56  ? B GLU 56  
395 1 Y 1 B LYS 57  ? B LYS 57  
396 1 Y 1 B PHE 58  ? B PHE 58  
397 1 Y 1 B PHE 59  ? B PHE 59  
398 1 Y 1 B GLN 60  ? B GLN 60  
399 1 Y 1 B THR 61  ? B THR 61  
400 1 Y 1 B CYS 62  ? B CYS 62  
401 1 Y 1 B GLU 63  ? B GLU 63  
402 1 Y 1 B LYS 64  ? B LYS 64  
403 1 Y 1 B GLU 65  ? B GLU 65  
404 1 Y 1 B LEU 66  ? B LEU 66  
405 1 Y 1 B ALA 67  ? B ALA 67  
406 1 Y 1 B LYS 68  ? B LYS 68  
407 1 Y 1 B ILE 69  ? B ILE 69  
408 1 Y 1 B ASN 70  ? B ASN 70  
409 1 Y 1 B THR 71  ? B THR 71  
410 1 Y 1 B PHE 72  ? B PHE 72  
411 1 Y 1 B TYR 73  ? B TYR 73  
412 1 Y 1 B SER 74  ? B SER 74  
413 1 Y 1 B GLU 75  ? B GLU 75  
414 1 Y 1 B LYS 76  ? B LYS 76  
415 1 Y 1 B LEU 77  ? B LEU 77  
416 1 Y 1 B ALA 78  ? B ALA 78  
417 1 Y 1 B GLU 79  ? B GLU 79  
418 1 Y 1 B ALA 80  ? B ALA 80  
419 1 Y 1 B GLN 81  ? B GLN 81  
420 1 Y 1 B ARG 82  ? B ARG 82  
421 1 Y 1 B ARG 83  ? B ARG 83  
422 1 Y 1 B PHE 84  ? B PHE 84  
423 1 Y 1 B ALA 85  ? B ALA 85  
424 1 Y 1 B THR 86  ? B THR 86  
425 1 Y 1 B LEU 87  ? B LEU 87  
426 1 Y 1 B GLN 88  ? B GLN 88  
427 1 Y 1 B ASN 89  ? B ASN 89  
428 1 Y 1 B GLU 90  ? B GLU 90  
429 1 Y 1 B LEU 91  ? B LEU 91  
430 1 Y 1 B GLN 92  ? B GLN 92  
431 1 Y 1 B SER 93  ? B SER 93  
432 1 Y 1 B SER 94  ? B SER 94  
433 1 Y 1 B LEU 95  ? B LEU 95  
434 1 Y 1 B ASP 96  ? B ASP 96  
435 1 Y 1 B ALA 97  ? B ALA 97  
436 1 Y 1 B GLN 98  ? B GLN 98  
437 1 Y 1 B LYS 99  ? B LYS 99  
438 1 Y 1 B GLU 100 ? B GLU 100 
439 1 Y 1 B SER 101 ? B SER 101 
440 1 Y 1 B THR 102 ? B THR 102 
441 1 Y 1 B GLY 103 ? B GLY 103 
442 1 Y 1 B VAL 104 ? B VAL 104 
443 1 Y 1 B THR 105 ? B THR 105 
444 1 Y 1 B THR 106 ? B THR 106 
445 1 Y 1 B LEU 107 ? B LEU 107 
446 1 Y 1 B ARG 108 ? B ARG 108 
447 1 Y 1 B GLN 109 ? B GLN 109 
448 1 Y 1 B ARG 110 ? B ARG 110 
449 1 Y 1 B ARG 111 ? B ARG 111 
450 1 Y 1 B LYS 112 ? B LYS 112 
451 1 Y 1 B PRO 113 ? B PRO 113 
452 1 Y 1 B VAL 114 ? B VAL 114 
453 1 Y 1 B PHE 115 ? B PHE 115 
454 1 Y 1 B HIS 116 ? B HIS 116 
455 1 Y 1 B LEU 117 ? B LEU 117 
456 1 Y 1 B SER 118 ? B SER 118 
457 1 Y 1 B HIS 119 ? B HIS 119 
458 1 Y 1 B GLU 120 ? B GLU 120 
459 1 Y 1 B GLU 121 ? B GLU 121 
460 1 Y 1 B ARG 122 ? B ARG 122 
461 1 Y 1 B VAL 123 ? B VAL 123 
462 1 Y 1 B GLN 124 ? B GLN 124 
463 1 Y 1 B HIS 125 ? B HIS 125 
464 1 Y 1 B ARG 126 ? B ARG 126 
465 1 Y 1 B ASN 127 ? B ASN 127 
466 1 Y 1 B ILE 128 ? B ILE 128 
467 1 Y 1 B LYS 129 ? B LYS 129 
468 1 Y 1 B ASP 130 ? B ASP 130 
469 1 Y 1 B LEU 131 ? B LEU 131 
470 1 Y 1 B LYS 132 ? B LYS 132 
471 1 Y 1 B LEU 133 ? B LEU 133 
472 1 Y 1 B ALA 134 ? B ALA 134 
473 1 Y 1 B PHE 135 ? B PHE 135 
474 1 Y 1 B SER 136 ? B SER 136 
475 1 Y 1 B GLU 137 ? B GLU 137 
476 1 Y 1 B PHE 138 ? B PHE 138 
477 1 Y 1 B TYR 139 ? B TYR 139 
478 1 Y 1 B LEU 140 ? B LEU 140 
479 1 Y 1 B SER 141 ? B SER 141 
480 1 Y 1 B LEU 142 ? B LEU 142 
481 1 Y 1 B ILE 143 ? B ILE 143 
482 1 Y 1 B LEU 144 ? B LEU 144 
483 1 Y 1 B LEU 145 ? B LEU 145 
484 1 Y 1 B GLN 146 ? B GLN 146 
485 1 Y 1 B ASN 147 ? B ASN 147 
486 1 Y 1 B TYR 148 ? B TYR 148 
487 1 Y 1 B GLN 149 ? B GLN 149 
488 1 Y 1 B ASN 150 ? B ASN 150 
489 1 Y 1 B LEU 151 ? B LEU 151 
490 1 Y 1 B ASN 152 ? B ASN 152 
491 1 Y 1 B PHE 153 ? B PHE 153 
492 1 Y 1 B THR 154 ? B THR 154 
493 1 Y 1 B GLY 155 ? B GLY 155 
494 1 Y 1 B PHE 156 ? B PHE 156 
495 1 Y 1 B ARG 157 ? B ARG 157 
496 1 Y 1 B LYS 158 ? B LYS 158 
497 1 Y 1 B ILE 159 ? B ILE 159 
498 1 Y 1 B LEU 160 ? B LEU 160 
499 1 Y 1 B LYS 161 ? B LYS 161 
500 1 Y 1 B LYS 162 ? B LYS 162 
501 1 Y 1 B HIS 163 ? B HIS 163 
502 1 Y 1 B ASP 164 ? B ASP 164 
503 1 Y 1 B LYS 165 ? B LYS 165 
504 1 Y 1 B ILE 166 ? B ILE 166 
505 1 Y 1 B LEU 167 ? B LEU 167 
506 1 Y 1 B GLU 168 ? B GLU 168 
507 1 Y 1 B THR 169 ? B THR 169 
508 1 Y 1 B SER 170 ? B SER 170 
509 1 Y 1 B ARG 171 ? B ARG 171 
510 1 Y 1 B GLY 172 ? B GLY 172 
511 1 Y 1 B ALA 173 ? B ALA 173 
512 1 Y 1 B ASP 174 ? B ASP 174 
513 1 Y 1 B TRP 175 ? B TRP 175 
514 1 Y 1 B ARG 176 ? B ARG 176 
515 1 Y 1 B VAL 177 ? B VAL 177 
516 1 Y 1 B ALA 178 ? B ALA 178 
517 1 Y 1 B HIS 179 ? B HIS 179 
518 1 Y 1 B VAL 180 ? B VAL 180 
519 1 Y 1 B GLU 181 ? B GLU 181 
520 1 Y 1 B VAL 182 ? B VAL 182 
521 1 Y 1 B ALA 183 ? B ALA 183 
522 1 Y 1 B PRO 184 ? B PRO 184 
523 1 Y 1 B PHE 185 ? B PHE 185 
524 1 Y 1 B TYR 186 ? B TYR 186 
525 1 Y 1 B THR 187 ? B THR 187 
526 1 Y 1 B CYS 188 ? B CYS 188 
527 1 Y 1 B LYS 189 ? B LYS 189 
528 1 Y 1 B LYS 190 ? B LYS 190 
529 1 Y 1 B ILE 191 ? B ILE 191 
530 1 Y 1 B ASN 192 ? B ASN 192 
531 1 Y 1 B GLN 193 ? B GLN 193 
532 1 Y 1 B LEU 194 ? B LEU 194 
533 1 Y 1 B ILE 195 ? B ILE 195 
534 1 Y 1 B SER 196 ? B SER 196 
535 1 Y 1 B GLU 197 ? B GLU 197 
536 1 Y 1 B THR 198 ? B THR 198 
537 1 Y 1 B GLU 199 ? B GLU 199 
538 1 Y 1 B ALA 200 ? B ALA 200 
539 1 Y 1 B VAL 201 ? B VAL 201 
540 1 Y 1 B VAL 202 ? B VAL 202 
541 1 Y 1 B THR 203 ? B THR 203 
542 1 Y 1 B ASN 204 ? B ASN 204 
543 1 Y 1 B GLU 205 ? B GLU 205 
544 1 Y 1 B LEU 206 ? B LEU 206 
545 1 Y 1 B GLU 207 ? B GLU 207 
546 1 Y 1 B ASP 208 ? B ASP 208 
547 1 Y 1 B GLY 209 ? B GLY 209 
548 1 Y 1 B ASP 210 ? B ASP 210 
549 1 Y 1 B ARG 211 ? B ARG 211 
550 1 Y 1 B GLN 212 ? B GLN 212 
551 1 Y 1 B LYS 213 ? B LYS 213 
552 1 Y 1 B ALA 214 ? B ALA 214 
553 1 Y 1 B MET 215 ? B MET 215 
554 1 Y 1 B LYS 216 ? B LYS 216 
555 1 Y 1 B ARG 217 ? B ARG 217 
556 1 Y 1 B LEU 218 ? B LEU 218 
557 1 Y 1 B ARG 219 ? B ARG 219 
558 1 Y 1 B VAL 220 ? B VAL 220 
559 1 Y 1 B PRO 221 ? B PRO 221 
560 1 Y 1 B PRO 222 ? B PRO 222 
561 1 Y 1 B LEU 223 ? B LEU 223 
562 1 Y 1 B GLY 224 ? B GLY 224 
563 1 Y 1 B ALA 225 ? B ALA 225 
564 1 Y 1 B ALA 226 ? B ALA 226 
565 1 Y 1 B GLN 227 ? B GLN 227 
566 1 Y 1 B PRO 228 ? B PRO 228 
567 1 Y 1 B ASN 432 ? B ASN 432 
568 1 Y 1 B ASN 433 ? B ASN 433 
569 1 Y 1 B SER 434 ? B SER 434 
570 1 Y 1 B GLU 435 ? B GLU 435 
571 1 Y 1 B GLU 436 ? B GLU 436 
572 1 Y 1 B SER 437 ? B SER 437 
573 1 Y 1 B GLY 438 ? B GLY 438 
574 1 Y 1 B ILE 439 ? B ILE 439 
575 1 Y 1 B CYS 440 ? B CYS 440 
576 1 Y 1 B HIS 441 ? B HIS 441 
577 1 Y 1 B LYS 442 ? B LYS 442 
578 1 Y 1 B TYR 443 ? B TYR 443 
579 1 Y 1 B THR 444 ? B THR 444 
580 1 Y 1 B TYR 445 ? B TYR 445 
581 1 Y 1 B ALA 625 ? B ALA 625 
582 1 Y 1 B VAL 626 ? B VAL 626 
583 1 Y 1 B ARG 627 ? B ARG 627 
584 1 Y 1 B ASP 628 ? B ASP 628 
585 1 Y 1 B ILE 629 ? B ILE 629 
586 1 Y 1 B SER 630 ? B SER 630 
587 1 Y 1 B VAL 631 ? B VAL 631 
588 1 Y 1 B ALA 632 ? B ALA 632 
589 1 Y 1 B PRO 633 ? B PRO 633 
590 1 Y 1 B LEU 634 ? B LEU 634 
591 1 Y 1 B ASN 635 ? B ASN 635 
592 1 Y 1 B ALA 636 ? B ALA 636 
593 1 Y 1 B ASP 637 ? B ASP 637 
594 1 Y 1 B ASP 638 ? B ASP 638 
595 1 Y 1 B GLN 639 ? B GLN 639 
596 1 Y 1 B THR 640 ? B THR 640 
597 1 Y 1 B LEU 641 ? B LEU 641 
598 1 Y 1 B LEU 642 ? B LEU 642 
599 1 Y 1 B GLU 643 ? B GLU 643 
600 1 Y 1 B GLN 644 ? B GLN 644 
601 1 Y 1 B MET 645 ? B MET 645 
602 1 Y 1 B MET 646 ? B MET 646 
603 1 Y 1 B ASP 647 ? B ASP 647 
604 1 Y 1 B GLN 648 ? B GLN 648 
605 1 Y 1 B ASP 649 ? B ASP 649 
606 1 Y 1 B ASP 650 ? B ASP 650 
607 1 Y 1 B GLY 651 ? B GLY 651 
608 1 Y 1 B VAL 652 ? B VAL 652 
609 1 Y 1 B ARG 653 ? B ARG 653 
610 1 Y 1 B ASN 654 ? B ASN 654 
611 1 Y 1 B ARG 655 ? B ARG 655 
612 1 Y 1 B GLN 656 ? B GLN 656 
613 1 Y 1 B LYS 657 ? B LYS 657 
614 1 Y 1 B ASN 658 ? B ASN 658 
615 1 Y 1 B ARG 659 ? B ARG 659 
616 1 Y 1 B SER 660 ? B SER 660 
617 1 Y 1 B TRP 661 ? B TRP 661 
618 1 Y 1 B LYS 662 ? B LYS 662 
619 1 Y 1 B TYR 663 ? B TYR 663 
620 1 Y 1 B ASN 664 ? B ASN 664 
621 1 Y 1 B GLN 665 ? B GLN 665 
622 1 Y 1 B SER 666 ? B SER 666 
623 1 Y 1 B ILE 667 ? B ILE 667 
624 1 Y 1 B SER 668 ? B SER 668 
625 1 Y 1 B LEU 669 ? B LEU 669 
626 1 Y 1 B ARG 670 ? B ARG 670 
627 1 Y 1 B ARG 671 ? B ARG 671 
628 1 Y 1 B PRO 672 ? B PRO 672 
629 1 Y 1 B ARG 673 ? B ARG 673 
630 1 Y 1 B LEU 674 ? B LEU 674 
631 1 Y 1 B ALA 675 ? B ALA 675 
632 1 Y 1 B SER 676 ? B SER 676 
633 1 Y 1 B GLN 677 ? B GLN 677 
634 1 Y 1 B SER 678 ? B SER 678 
635 1 Y 1 B LYS 679 ? B LYS 679 
636 1 Y 1 B ALA 680 ? B ALA 680 
637 1 Y 1 B ARG 681 ? B ARG 681 
638 1 Y 1 B ASP 682 ? B ASP 682 
639 1 Y 1 B THR 683 ? B THR 683 
640 1 Y 1 B LYS 684 ? B LYS 684 
641 1 Y 1 B VAL 685 ? B VAL 685 
642 1 Y 1 B LEU 686 ? B LEU 686 
643 1 Y 1 B ILE 687 ? B ILE 687 
644 1 Y 1 B GLU 688 ? B GLU 688 
645 1 Y 1 B ASP 689 ? B ASP 689 
646 1 Y 1 B THR 690 ? B THR 690 
647 1 Y 1 B ASP 691 ? B ASP 691 
648 1 Y 1 B ASP 692 ? B ASP 692 
649 1 Y 1 B GLU 693 ? B GLU 693 
650 1 Y 1 B ALA 694 ? B ALA 694 
651 1 Y 1 B ASN 695 ? B ASN 695 
652 1 Y 1 B THR 696 ? B THR 696 
653 1 Y 1 B LEU 697 ? B LEU 697 
654 1 Y 1 B GLU 698 ? B GLU 698 
655 1 Y 1 B ASP 699 ? B ASP 699 
656 1 Y 1 B TYR 700 ? B TYR 700 
657 1 Y 1 B LYS 701 ? B LYS 701 
658 1 Y 1 B ASP 702 ? B ASP 702 
659 1 Y 1 B HIS 703 ? B HIS 703 
660 1 Y 1 B ASP 704 ? B ASP 704 
661 1 Y 1 B GLY 705 ? B GLY 705 
662 1 Y 1 B ASP 706 ? B ASP 706 
663 1 Y 1 B TYR 707 ? B TYR 707 
664 1 Y 1 B LYS 708 ? B LYS 708 
665 1 Y 1 B ASP 709 ? B ASP 709 
666 1 Y 1 B HIS 710 ? B HIS 710 
667 1 Y 1 B ASP 711 ? B ASP 711 
668 1 Y 1 B ILE 712 ? B ILE 712 
669 1 Y 1 B ASP 713 ? B ASP 713 
670 1 Y 1 B TYR 714 ? B TYR 714 
671 1 Y 1 B LYS 715 ? B LYS 715 
672 1 Y 1 B ASP 716 ? B ASP 716 
673 1 Y 1 B ASP 717 ? B ASP 717 
674 1 Y 1 B ASP 718 ? B ASP 718 
675 1 Y 1 B ASP 719 ? B ASP 719 
676 1 Y 1 B LYS 720 ? B LYS 720 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PC1 O12  O N N 247 
PC1 P    P N N 248 
PC1 O14  O N N 249 
PC1 O13  O N N 250 
PC1 C11  C N N 251 
PC1 C12  C N N 252 
PC1 N    N N N 253 
PC1 C13  C N N 254 
PC1 C14  C N N 255 
PC1 C15  C N N 256 
PC1 O11  O N N 257 
PC1 C1   C N N 258 
PC1 C2   C N R 259 
PC1 O21  O N N 260 
PC1 C21  C N N 261 
PC1 O22  O N N 262 
PC1 C22  C N N 263 
PC1 C23  C N N 264 
PC1 C24  C N N 265 
PC1 C25  C N N 266 
PC1 C26  C N N 267 
PC1 C27  C N N 268 
PC1 C28  C N N 269 
PC1 C29  C N N 270 
PC1 C2A  C N N 271 
PC1 C2B  C N N 272 
PC1 C2C  C N N 273 
PC1 C2D  C N N 274 
PC1 C2E  C N N 275 
PC1 C2F  C N N 276 
PC1 C2G  C N N 277 
PC1 C2H  C N N 278 
PC1 C2I  C N N 279 
PC1 C3   C N N 280 
PC1 O31  O N N 281 
PC1 C31  C N N 282 
PC1 O32  O N N 283 
PC1 C32  C N N 284 
PC1 C33  C N N 285 
PC1 C34  C N N 286 
PC1 C35  C N N 287 
PC1 C36  C N N 288 
PC1 C37  C N N 289 
PC1 C38  C N N 290 
PC1 C39  C N N 291 
PC1 C3A  C N N 292 
PC1 C3B  C N N 293 
PC1 C3C  C N N 294 
PC1 C3D  C N N 295 
PC1 C3E  C N N 296 
PC1 C3F  C N N 297 
PC1 C3G  C N N 298 
PC1 C3H  C N N 299 
PC1 C3I  C N N 300 
PC1 H111 H N N 301 
PC1 H112 H N N 302 
PC1 H121 H N N 303 
PC1 H122 H N N 304 
PC1 H131 H N N 305 
PC1 H132 H N N 306 
PC1 H133 H N N 307 
PC1 H141 H N N 308 
PC1 H142 H N N 309 
PC1 H143 H N N 310 
PC1 H151 H N N 311 
PC1 H152 H N N 312 
PC1 H153 H N N 313 
PC1 H11  H N N 314 
PC1 H12  H N N 315 
PC1 H2   H N N 316 
PC1 H221 H N N 317 
PC1 H222 H N N 318 
PC1 H231 H N N 319 
PC1 H232 H N N 320 
PC1 H241 H N N 321 
PC1 H242 H N N 322 
PC1 H251 H N N 323 
PC1 H252 H N N 324 
PC1 H261 H N N 325 
PC1 H262 H N N 326 
PC1 H271 H N N 327 
PC1 H272 H N N 328 
PC1 H281 H N N 329 
PC1 H282 H N N 330 
PC1 H291 H N N 331 
PC1 H292 H N N 332 
PC1 H2A1 H N N 333 
PC1 H2A2 H N N 334 
PC1 H2B1 H N N 335 
PC1 H2B2 H N N 336 
PC1 H2C1 H N N 337 
PC1 H2C2 H N N 338 
PC1 H2D1 H N N 339 
PC1 H2D2 H N N 340 
PC1 H2E1 H N N 341 
PC1 H2E2 H N N 342 
PC1 H2F1 H N N 343 
PC1 H2F2 H N N 344 
PC1 H2G1 H N N 345 
PC1 H2G2 H N N 346 
PC1 H2H1 H N N 347 
PC1 H2H2 H N N 348 
PC1 H2I1 H N N 349 
PC1 H2I2 H N N 350 
PC1 H2I3 H N N 351 
PC1 H31  H N N 352 
PC1 H32  H N N 353 
PC1 H321 H N N 354 
PC1 H322 H N N 355 
PC1 H331 H N N 356 
PC1 H332 H N N 357 
PC1 H341 H N N 358 
PC1 H342 H N N 359 
PC1 H351 H N N 360 
PC1 H352 H N N 361 
PC1 H361 H N N 362 
PC1 H362 H N N 363 
PC1 H371 H N N 364 
PC1 H372 H N N 365 
PC1 H381 H N N 366 
PC1 H382 H N N 367 
PC1 H391 H N N 368 
PC1 H392 H N N 369 
PC1 H3A1 H N N 370 
PC1 H3A2 H N N 371 
PC1 H3B1 H N N 372 
PC1 H3B2 H N N 373 
PC1 H3C1 H N N 374 
PC1 H3C2 H N N 375 
PC1 H3D1 H N N 376 
PC1 H3D2 H N N 377 
PC1 H3E1 H N N 378 
PC1 H3E2 H N N 379 
PC1 H3F1 H N N 380 
PC1 H3F2 H N N 381 
PC1 H3G1 H N N 382 
PC1 H3G2 H N N 383 
PC1 H3H1 H N N 384 
PC1 H3H2 H N N 385 
PC1 H3I1 H N N 386 
PC1 H3I2 H N N 387 
PC1 H3I3 H N N 388 
PHE N    N N N 389 
PHE CA   C N S 390 
PHE C    C N N 391 
PHE O    O N N 392 
PHE CB   C N N 393 
PHE CG   C Y N 394 
PHE CD1  C Y N 395 
PHE CD2  C Y N 396 
PHE CE1  C Y N 397 
PHE CE2  C Y N 398 
PHE CZ   C Y N 399 
PHE OXT  O N N 400 
PHE H    H N N 401 
PHE H2   H N N 402 
PHE HA   H N N 403 
PHE HB2  H N N 404 
PHE HB3  H N N 405 
PHE HD1  H N N 406 
PHE HD2  H N N 407 
PHE HE1  H N N 408 
PHE HE2  H N N 409 
PHE HZ   H N N 410 
PHE HXT  H N N 411 
PRO N    N N N 412 
PRO CA   C N S 413 
PRO C    C N N 414 
PRO O    O N N 415 
PRO CB   C N N 416 
PRO CG   C N N 417 
PRO CD   C N N 418 
PRO OXT  O N N 419 
PRO H    H N N 420 
PRO HA   H N N 421 
PRO HB2  H N N 422 
PRO HB3  H N N 423 
PRO HG2  H N N 424 
PRO HG3  H N N 425 
PRO HD2  H N N 426 
PRO HD3  H N N 427 
PRO HXT  H N N 428 
SER N    N N N 429 
SER CA   C N S 430 
SER C    C N N 431 
SER O    O N N 432 
SER CB   C N N 433 
SER OG   O N N 434 
SER OXT  O N N 435 
SER H    H N N 436 
SER H2   H N N 437 
SER HA   H N N 438 
SER HB2  H N N 439 
SER HB3  H N N 440 
SER HG   H N N 441 
SER HXT  H N N 442 
THR N    N N N 443 
THR CA   C N S 444 
THR C    C N N 445 
THR O    O N N 446 
THR CB   C N R 447 
THR OG1  O N N 448 
THR CG2  C N N 449 
THR OXT  O N N 450 
THR H    H N N 451 
THR H2   H N N 452 
THR HA   H N N 453 
THR HB   H N N 454 
THR HG1  H N N 455 
THR HG21 H N N 456 
THR HG22 H N N 457 
THR HG23 H N N 458 
THR HXT  H N N 459 
TRP N    N N N 460 
TRP CA   C N S 461 
TRP C    C N N 462 
TRP O    O N N 463 
TRP CB   C N N 464 
TRP CG   C Y N 465 
TRP CD1  C Y N 466 
TRP CD2  C Y N 467 
TRP NE1  N Y N 468 
TRP CE2  C Y N 469 
TRP CE3  C Y N 470 
TRP CZ2  C Y N 471 
TRP CZ3  C Y N 472 
TRP CH2  C Y N 473 
TRP OXT  O N N 474 
TRP H    H N N 475 
TRP H2   H N N 476 
TRP HA   H N N 477 
TRP HB2  H N N 478 
TRP HB3  H N N 479 
TRP HD1  H N N 480 
TRP HE1  H N N 481 
TRP HE3  H N N 482 
TRP HZ2  H N N 483 
TRP HZ3  H N N 484 
TRP HH2  H N N 485 
TRP HXT  H N N 486 
TYR N    N N N 487 
TYR CA   C N S 488 
TYR C    C N N 489 
TYR O    O N N 490 
TYR CB   C N N 491 
TYR CG   C Y N 492 
TYR CD1  C Y N 493 
TYR CD2  C Y N 494 
TYR CE1  C Y N 495 
TYR CE2  C Y N 496 
TYR CZ   C Y N 497 
TYR OH   O N N 498 
TYR OXT  O N N 499 
TYR H    H N N 500 
TYR H2   H N N 501 
TYR HA   H N N 502 
TYR HB2  H N N 503 
TYR HB3  H N N 504 
TYR HD1  H N N 505 
TYR HD2  H N N 506 
TYR HE1  H N N 507 
TYR HE2  H N N 508 
TYR HH   H N N 509 
TYR HXT  H N N 510 
VAL N    N N N 511 
VAL CA   C N S 512 
VAL C    C N N 513 
VAL O    O N N 514 
VAL CB   C N N 515 
VAL CG1  C N N 516 
VAL CG2  C N N 517 
VAL OXT  O N N 518 
VAL H    H N N 519 
VAL H2   H N N 520 
VAL HA   H N N 521 
VAL HB   H N N 522 
VAL HG11 H N N 523 
VAL HG12 H N N 524 
VAL HG13 H N N 525 
VAL HG21 H N N 526 
VAL HG22 H N N 527 
VAL HG23 H N N 528 
VAL HXT  H N N 529 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PC1 O12 P    sing N N 235 
PC1 P   O14  doub N N 236 
PC1 P   O13  sing N N 237 
PC1 P   O11  sing N N 238 
PC1 O13 C11  sing N N 239 
PC1 C11 C12  sing N N 240 
PC1 C11 H111 sing N N 241 
PC1 C11 H112 sing N N 242 
PC1 C12 N    sing N N 243 
PC1 C12 H121 sing N N 244 
PC1 C12 H122 sing N N 245 
PC1 N   C13  sing N N 246 
PC1 N   C14  sing N N 247 
PC1 N   C15  sing N N 248 
PC1 C13 H131 sing N N 249 
PC1 C13 H132 sing N N 250 
PC1 C13 H133 sing N N 251 
PC1 C14 H141 sing N N 252 
PC1 C14 H142 sing N N 253 
PC1 C14 H143 sing N N 254 
PC1 C15 H151 sing N N 255 
PC1 C15 H152 sing N N 256 
PC1 C15 H153 sing N N 257 
PC1 O11 C1   sing N N 258 
PC1 C1  C2   sing N N 259 
PC1 C1  H11  sing N N 260 
PC1 C1  H12  sing N N 261 
PC1 C2  O21  sing N N 262 
PC1 C2  C3   sing N N 263 
PC1 C2  H2   sing N N 264 
PC1 O21 C21  sing N N 265 
PC1 C21 O22  doub N N 266 
PC1 C21 C22  sing N N 267 
PC1 C22 C23  sing N N 268 
PC1 C22 H221 sing N N 269 
PC1 C22 H222 sing N N 270 
PC1 C23 C24  sing N N 271 
PC1 C23 H231 sing N N 272 
PC1 C23 H232 sing N N 273 
PC1 C24 C25  sing N N 274 
PC1 C24 H241 sing N N 275 
PC1 C24 H242 sing N N 276 
PC1 C25 C26  sing N N 277 
PC1 C25 H251 sing N N 278 
PC1 C25 H252 sing N N 279 
PC1 C26 C27  sing N N 280 
PC1 C26 H261 sing N N 281 
PC1 C26 H262 sing N N 282 
PC1 C27 C28  sing N N 283 
PC1 C27 H271 sing N N 284 
PC1 C27 H272 sing N N 285 
PC1 C28 C29  sing N N 286 
PC1 C28 H281 sing N N 287 
PC1 C28 H282 sing N N 288 
PC1 C29 C2A  sing N N 289 
PC1 C29 H291 sing N N 290 
PC1 C29 H292 sing N N 291 
PC1 C2A C2B  sing N N 292 
PC1 C2A H2A1 sing N N 293 
PC1 C2A H2A2 sing N N 294 
PC1 C2B C2C  sing N N 295 
PC1 C2B H2B1 sing N N 296 
PC1 C2B H2B2 sing N N 297 
PC1 C2C C2D  sing N N 298 
PC1 C2C H2C1 sing N N 299 
PC1 C2C H2C2 sing N N 300 
PC1 C2D C2E  sing N N 301 
PC1 C2D H2D1 sing N N 302 
PC1 C2D H2D2 sing N N 303 
PC1 C2E C2F  sing N N 304 
PC1 C2E H2E1 sing N N 305 
PC1 C2E H2E2 sing N N 306 
PC1 C2F C2G  sing N N 307 
PC1 C2F H2F1 sing N N 308 
PC1 C2F H2F2 sing N N 309 
PC1 C2G C2H  sing N N 310 
PC1 C2G H2G1 sing N N 311 
PC1 C2G H2G2 sing N N 312 
PC1 C2H C2I  sing N N 313 
PC1 C2H H2H1 sing N N 314 
PC1 C2H H2H2 sing N N 315 
PC1 C2I H2I1 sing N N 316 
PC1 C2I H2I2 sing N N 317 
PC1 C2I H2I3 sing N N 318 
PC1 C3  O31  sing N N 319 
PC1 C3  H31  sing N N 320 
PC1 C3  H32  sing N N 321 
PC1 O31 C31  sing N N 322 
PC1 C31 O32  doub N N 323 
PC1 C31 C32  sing N N 324 
PC1 C32 C33  sing N N 325 
PC1 C32 H321 sing N N 326 
PC1 C32 H322 sing N N 327 
PC1 C33 C34  sing N N 328 
PC1 C33 H331 sing N N 329 
PC1 C33 H332 sing N N 330 
PC1 C34 C35  sing N N 331 
PC1 C34 H341 sing N N 332 
PC1 C34 H342 sing N N 333 
PC1 C35 C36  sing N N 334 
PC1 C35 H351 sing N N 335 
PC1 C35 H352 sing N N 336 
PC1 C36 C37  sing N N 337 
PC1 C36 H361 sing N N 338 
PC1 C36 H362 sing N N 339 
PC1 C37 C38  sing N N 340 
PC1 C37 H371 sing N N 341 
PC1 C37 H372 sing N N 342 
PC1 C38 C39  sing N N 343 
PC1 C38 H381 sing N N 344 
PC1 C38 H382 sing N N 345 
PC1 C39 C3A  sing N N 346 
PC1 C39 H391 sing N N 347 
PC1 C39 H392 sing N N 348 
PC1 C3A C3B  sing N N 349 
PC1 C3A H3A1 sing N N 350 
PC1 C3A H3A2 sing N N 351 
PC1 C3B C3C  sing N N 352 
PC1 C3B H3B1 sing N N 353 
PC1 C3B H3B2 sing N N 354 
PC1 C3C C3D  sing N N 355 
PC1 C3C H3C1 sing N N 356 
PC1 C3C H3C2 sing N N 357 
PC1 C3D C3E  sing N N 358 
PC1 C3D H3D1 sing N N 359 
PC1 C3D H3D2 sing N N 360 
PC1 C3E C3F  sing N N 361 
PC1 C3E H3E1 sing N N 362 
PC1 C3E H3E2 sing N N 363 
PC1 C3F C3G  sing N N 364 
PC1 C3F H3F1 sing N N 365 
PC1 C3F H3F2 sing N N 366 
PC1 C3G C3H  sing N N 367 
PC1 C3G H3G1 sing N N 368 
PC1 C3G H3G2 sing N N 369 
PC1 C3H C3I  sing N N 370 
PC1 C3H H3H1 sing N N 371 
PC1 C3H H3H2 sing N N 372 
PC1 C3I H3I1 sing N N 373 
PC1 C3I H3I2 sing N N 374 
PC1 C3I H3I3 sing N N 375 
PHE N   CA   sing N N 376 
PHE N   H    sing N N 377 
PHE N   H2   sing N N 378 
PHE CA  C    sing N N 379 
PHE CA  CB   sing N N 380 
PHE CA  HA   sing N N 381 
PHE C   O    doub N N 382 
PHE C   OXT  sing N N 383 
PHE CB  CG   sing N N 384 
PHE CB  HB2  sing N N 385 
PHE CB  HB3  sing N N 386 
PHE CG  CD1  doub Y N 387 
PHE CG  CD2  sing Y N 388 
PHE CD1 CE1  sing Y N 389 
PHE CD1 HD1  sing N N 390 
PHE CD2 CE2  doub Y N 391 
PHE CD2 HD2  sing N N 392 
PHE CE1 CZ   doub Y N 393 
PHE CE1 HE1  sing N N 394 
PHE CE2 CZ   sing Y N 395 
PHE CE2 HE2  sing N N 396 
PHE CZ  HZ   sing N N 397 
PHE OXT HXT  sing N N 398 
PRO N   CA   sing N N 399 
PRO N   CD   sing N N 400 
PRO N   H    sing N N 401 
PRO CA  C    sing N N 402 
PRO CA  CB   sing N N 403 
PRO CA  HA   sing N N 404 
PRO C   O    doub N N 405 
PRO C   OXT  sing N N 406 
PRO CB  CG   sing N N 407 
PRO CB  HB2  sing N N 408 
PRO CB  HB3  sing N N 409 
PRO CG  CD   sing N N 410 
PRO CG  HG2  sing N N 411 
PRO CG  HG3  sing N N 412 
PRO CD  HD2  sing N N 413 
PRO CD  HD3  sing N N 414 
PRO OXT HXT  sing N N 415 
SER N   CA   sing N N 416 
SER N   H    sing N N 417 
SER N   H2   sing N N 418 
SER CA  C    sing N N 419 
SER CA  CB   sing N N 420 
SER CA  HA   sing N N 421 
SER C   O    doub N N 422 
SER C   OXT  sing N N 423 
SER CB  OG   sing N N 424 
SER CB  HB2  sing N N 425 
SER CB  HB3  sing N N 426 
SER OG  HG   sing N N 427 
SER OXT HXT  sing N N 428 
THR N   CA   sing N N 429 
THR N   H    sing N N 430 
THR N   H2   sing N N 431 
THR CA  C    sing N N 432 
THR CA  CB   sing N N 433 
THR CA  HA   sing N N 434 
THR C   O    doub N N 435 
THR C   OXT  sing N N 436 
THR CB  OG1  sing N N 437 
THR CB  CG2  sing N N 438 
THR CB  HB   sing N N 439 
THR OG1 HG1  sing N N 440 
THR CG2 HG21 sing N N 441 
THR CG2 HG22 sing N N 442 
THR CG2 HG23 sing N N 443 
THR OXT HXT  sing N N 444 
TRP N   CA   sing N N 445 
TRP N   H    sing N N 446 
TRP N   H2   sing N N 447 
TRP CA  C    sing N N 448 
TRP CA  CB   sing N N 449 
TRP CA  HA   sing N N 450 
TRP C   O    doub N N 451 
TRP C   OXT  sing N N 452 
TRP CB  CG   sing N N 453 
TRP CB  HB2  sing N N 454 
TRP CB  HB3  sing N N 455 
TRP CG  CD1  doub Y N 456 
TRP CG  CD2  sing Y N 457 
TRP CD1 NE1  sing Y N 458 
TRP CD1 HD1  sing N N 459 
TRP CD2 CE2  doub Y N 460 
TRP CD2 CE3  sing Y N 461 
TRP NE1 CE2  sing Y N 462 
TRP NE1 HE1  sing N N 463 
TRP CE2 CZ2  sing Y N 464 
TRP CE3 CZ3  doub Y N 465 
TRP CE3 HE3  sing N N 466 
TRP CZ2 CH2  doub Y N 467 
TRP CZ2 HZ2  sing N N 468 
TRP CZ3 CH2  sing Y N 469 
TRP CZ3 HZ3  sing N N 470 
TRP CH2 HH2  sing N N 471 
TRP OXT HXT  sing N N 472 
TYR N   CA   sing N N 473 
TYR N   H    sing N N 474 
TYR N   H2   sing N N 475 
TYR CA  C    sing N N 476 
TYR CA  CB   sing N N 477 
TYR CA  HA   sing N N 478 
TYR C   O    doub N N 479 
TYR C   OXT  sing N N 480 
TYR CB  CG   sing N N 481 
TYR CB  HB2  sing N N 482 
TYR CB  HB3  sing N N 483 
TYR CG  CD1  doub Y N 484 
TYR CG  CD2  sing Y N 485 
TYR CD1 CE1  sing Y N 486 
TYR CD1 HD1  sing N N 487 
TYR CD2 CE2  doub Y N 488 
TYR CD2 HD2  sing N N 489 
TYR CE1 CZ   doub Y N 490 
TYR CE1 HE1  sing N N 491 
TYR CE2 CZ   sing Y N 492 
TYR CE2 HE2  sing N N 493 
TYR CZ  OH   sing N N 494 
TYR OH  HH   sing N N 495 
TYR OXT HXT  sing N N 496 
VAL N   CA   sing N N 497 
VAL N   H    sing N N 498 
VAL N   H2   sing N N 499 
VAL CA  C    sing N N 500 
VAL CA  CB   sing N N 501 
VAL CA  HA   sing N N 502 
VAL C   O    doub N N 503 
VAL C   OXT  sing N N 504 
VAL CB  CG1  sing N N 505 
VAL CB  CG2  sing N N 506 
VAL CB  HB   sing N N 507 
VAL CG1 HG11 sing N N 508 
VAL CG1 HG12 sing N N 509 
VAL CG1 HG13 sing N N 510 
VAL CG2 HG21 sing N N 511 
VAL CG2 HG22 sing N N 512 
VAL CG2 HG23 sing N N 513 
VAL OXT HXT  sing N N 514 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-08-10 
_em_admin.deposition_site    PDBJ 
_em_admin.entry_id           9J4X 
_em_admin.last_update        2025-01-15 
_em_admin.map_release_date   2024-12-04 
_em_admin.title              'CryoEM structure of human XPR1 in apo state' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     NONE 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          9606 
_em_entity_assembly_recombinant.organism             'Homo sapiens' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         50 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 BIOQUANTUM (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'       ? 1  1 ? ? ? ? 
'IMAGE ACQUISITION'        ? 2  ? ? 1 ? ? 
MASKING                    ? 3  ? ? ? ? ? 
'CTF CORRECTION'           ? 4  1 ? ? ? ? 
'LAYERLINE INDEXING'       ? 5  ? ? ? ? ? 
'DIFFRACTION INDEXING'     ? 6  ? ? ? ? ? 
'MODEL FITTING'            ? 7  ? ? ? ? ? 
'MODEL REFINEMENT'         ? 8  ? ? ? ? ? 
OTHER                      ? 9  ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT' ? 10 1 ? ? ? ? 
'FINAL EULER ASSIGNMENT'   ? 11 1 ? ? ? ? 
CLASSIFICATION             ? 12 1 ? ? ? ? 
RECONSTRUCTION             ? 13 1 ? ? ? ? 
# 
_em_specimen.concentration           4.7 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    9J4X 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
P 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . ALA A 1 229 ? 154.475 146.053 124.706 1.00 50.49  ? 229 ALA A N   1 
ATOM   2    C CA  . ALA A 1 229 ? 154.213 145.191 125.852 1.00 57.10  ? 229 ALA A CA  1 
ATOM   3    C C   . ALA A 1 229 ? 152.714 145.044 126.093 1.00 58.55  ? 229 ALA A C   1 
ATOM   4    O O   . ALA A 1 229 ? 151.951 145.979 125.854 1.00 58.58  ? 229 ALA A O   1 
ATOM   5    C CB  . ALA A 1 229 ? 154.899 145.737 127.092 1.00 47.91  ? 229 ALA A CB  1 
ATOM   6    N N   . PRO A 1 230 ? 152.294 143.868 126.560 1.00 48.88  ? 230 PRO A N   1 
ATOM   7    C CA  . PRO A 1 230 ? 150.872 143.660 126.855 1.00 46.95  ? 230 PRO A CA  1 
ATOM   8    C C   . PRO A 1 230 ? 150.383 144.614 127.933 1.00 42.03  ? 230 PRO A C   1 
ATOM   9    O O   . PRO A 1 230 ? 151.132 145.021 128.822 1.00 42.39  ? 230 PRO A O   1 
ATOM   10   C CB  . PRO A 1 230 ? 150.817 142.204 127.330 1.00 44.50  ? 230 PRO A CB  1 
ATOM   11   C CG  . PRO A 1 230 ? 152.030 141.570 126.742 1.00 45.47  ? 230 PRO A CG  1 
ATOM   12   C CD  . PRO A 1 230 ? 153.080 142.636 126.736 1.00 45.25  ? 230 PRO A CD  1 
ATOM   13   N N   . ALA A 1 231 ? 149.102 144.977 127.836 1.00 36.01  ? 231 ALA A N   1 
ATOM   14   C CA  . ALA A 1 231 ? 148.518 145.908 128.796 1.00 35.67  ? 231 ALA A CA  1 
ATOM   15   C C   . ALA A 1 231 ? 148.480 145.314 130.198 1.00 30.85  ? 231 ALA A C   1 
ATOM   16   O O   . ALA A 1 231 ? 148.678 146.031 131.185 1.00 30.57  ? 231 ALA A O   1 
ATOM   17   C CB  . ALA A 1 231 ? 147.116 146.312 128.346 1.00 47.42  ? 231 ALA A CB  1 
ATOM   18   N N   . TRP A 1 232 ? 148.215 144.011 130.309 1.00 30.19  ? 232 TRP A N   1 
ATOM   19   C CA  . TRP A 1 232 ? 148.210 143.372 131.620 1.00 28.85  ? 232 TRP A CA  1 
ATOM   20   C C   . TRP A 1 232 ? 149.591 143.380 132.255 1.00 28.17  ? 232 TRP A C   1 
ATOM   21   O O   . TRP A 1 232 ? 149.703 143.431 133.482 1.00 27.09  ? 232 TRP A O   1 
ATOM   22   C CB  . TRP A 1 232 ? 147.686 141.942 131.518 1.00 31.02  ? 232 TRP A CB  1 
ATOM   23   C CG  . TRP A 1 232 ? 146.201 141.856 131.405 1.00 35.71  ? 232 TRP A CG  1 
ATOM   24   C CD1 . TRP A 1 232 ? 145.480 141.566 130.288 1.00 34.53  ? 232 TRP A CD1 1 
ATOM   25   C CD2 . TRP A 1 232 ? 145.249 142.070 132.453 1.00 37.71  ? 232 TRP A CD2 1 
ATOM   26   N NE1 . TRP A 1 232 ? 144.138 141.582 130.574 1.00 40.89  ? 232 TRP A NE1 1 
ATOM   27   C CE2 . TRP A 1 232 ? 143.971 141.889 131.898 1.00 40.02  ? 232 TRP A CE2 1 
ATOM   28   C CE3 . TRP A 1 232 ? 145.355 142.395 133.807 1.00 32.52  ? 232 TRP A CE3 1 
ATOM   29   C CZ2 . TRP A 1 232 ? 142.807 142.024 132.648 1.00 37.57  ? 232 TRP A CZ2 1 
ATOM   30   C CZ3 . TRP A 1 232 ? 144.200 142.528 134.548 1.00 30.92  ? 232 TRP A CZ3 1 
ATOM   31   C CH2 . TRP A 1 232 ? 142.944 142.342 133.968 1.00 32.40  ? 232 TRP A CH2 1 
ATOM   32   N N   . THR A 1 233 ? 150.650 143.329 131.445 1.00 28.50  ? 233 THR A N   1 
ATOM   33   C CA  . THR A 1 233 ? 151.999 143.430 131.991 1.00 26.95  ? 233 THR A CA  1 
ATOM   34   C C   . THR A 1 233 ? 152.227 144.793 132.632 1.00 24.28  ? 233 THR A C   1 
ATOM   35   O O   . THR A 1 233 ? 152.764 144.889 133.739 1.00 24.06  ? 233 THR A O   1 
ATOM   36   C CB  . THR A 1 233 ? 153.032 143.169 130.895 1.00 35.71  ? 233 THR A CB  1 
ATOM   37   O OG1 . THR A 1 233 ? 152.897 141.824 130.423 1.00 44.84  ? 233 THR A OG1 1 
ATOM   38   C CG2 . THR A 1 233 ? 154.439 143.369 131.430 1.00 29.44  ? 233 THR A CG2 1 
ATOM   39   N N   . THR A 1 234 ? 151.812 145.861 131.947 1.00 26.20  ? 234 THR A N   1 
ATOM   40   C CA  . THR A 1 234 ? 151.928 147.201 132.515 1.00 20.10  ? 234 THR A CA  1 
ATOM   41   C C   . THR A 1 234 ? 151.064 147.346 133.759 1.00 18.44  ? 234 THR A C   1 
ATOM   42   O O   . THR A 1 234 ? 151.468 147.985 134.739 1.00 16.95  ? 234 THR A O   1 
ATOM   43   C CB  . THR A 1 234 ? 151.537 148.244 131.473 1.00 16.86  ? 234 THR A CB  1 
ATOM   44   O OG1 . THR A 1 234 ? 152.167 147.932 130.226 1.00 23.20  ? 234 THR A OG1 1 
ATOM   45   C CG2 . THR A 1 234 ? 151.979 149.619 131.917 1.00 19.48  ? 234 THR A CG2 1 
ATOM   46   N N   . PHE A 1 235 ? 149.867 146.756 133.740 1.00 20.93  ? 235 PHE A N   1 
ATOM   47   C CA  . PHE A 1 235 ? 149.018 146.789 134.923 1.00 19.91  ? 235 PHE A CA  1 
ATOM   48   C C   . PHE A 1 235 ? 149.685 146.094 136.100 1.00 18.23  ? 235 PHE A C   1 
ATOM   49   O O   . PHE A 1 235 ? 149.631 146.589 137.227 1.00 14.69  ? 235 PHE A O   1 
ATOM   50   C CB  . PHE A 1 235 ? 147.662 146.147 134.630 1.00 20.56  ? 235 PHE A CB  1 
ATOM   51   C CG  . PHE A 1 235 ? 146.836 145.914 135.861 1.00 19.59  ? 235 PHE A CG  1 
ATOM   52   C CD1 . PHE A 1 235 ? 146.149 146.953 136.452 1.00 15.59  ? 235 PHE A CD1 1 
ATOM   53   C CD2 . PHE A 1 235 ? 146.761 144.660 136.435 1.00 19.82  ? 235 PHE A CD2 1 
ATOM   54   C CE1 . PHE A 1 235 ? 145.404 146.747 137.587 1.00 12.20  ? 235 PHE A CE1 1 
ATOM   55   C CE2 . PHE A 1 235 ? 146.015 144.452 137.570 1.00 21.31  ? 235 PHE A CE2 1 
ATOM   56   C CZ  . PHE A 1 235 ? 145.336 145.498 138.145 1.00 14.75  ? 235 PHE A CZ  1 
ATOM   57   N N   . ARG A 1 236 ? 150.308 144.938 135.863 1.00 22.27  ? 236 ARG A N   1 
ATOM   58   C CA  . ARG A 1 236 ? 150.962 144.222 136.953 1.00 20.21  ? 236 ARG A CA  1 
ATOM   59   C C   . ARG A 1 236 ? 152.194 144.967 137.445 1.00 17.72  ? 236 ARG A C   1 
ATOM   60   O O   . ARG A 1 236 ? 152.488 144.958 138.644 1.00 20.09  ? 236 ARG A O   1 
ATOM   61   C CB  . ARG A 1 236 ? 151.326 142.804 136.517 1.00 21.72  ? 236 ARG A CB  1 
ATOM   62   C CG  . ARG A 1 236 ? 150.173 141.819 136.578 1.00 17.89  ? 236 ARG A CG  1 
ATOM   63   C CD  . ARG A 1 236 ? 150.657 140.402 136.366 1.00 14.40  ? 236 ARG A CD  1 
ATOM   64   N NE  . ARG A 1 236 ? 151.391 140.267 135.115 1.00 26.19  ? 236 ARG A NE  1 
ATOM   65   C CZ  . ARG A 1 236 ? 150.860 139.843 133.977 1.00 29.89  ? 236 ARG A CZ  1 
ATOM   66   N NH1 . ARG A 1 236 ? 149.592 139.479 133.901 1.00 28.80  ? 236 ARG A NH1 1 
ATOM   67   N NH2 . ARG A 1 236 ? 151.622 139.780 132.890 1.00 25.36  ? 236 ARG A NH2 1 
ATOM   68   N N   . VAL A 1 237 ? 152.922 145.625 136.541 1.00 15.50  ? 237 VAL A N   1 
ATOM   69   C CA  . VAL A 1 237 ? 154.047 146.458 136.961 1.00 14.56  ? 237 VAL A CA  1 
ATOM   70   C C   . VAL A 1 237 ? 153.561 147.568 137.882 1.00 18.08  ? 237 VAL A C   1 
ATOM   71   O O   . VAL A 1 237 ? 154.126 147.800 138.957 1.00 22.11  ? 237 VAL A O   1 
ATOM   72   C CB  . VAL A 1 237 ? 154.785 147.029 135.738 1.00 14.44  ? 237 VAL A CB  1 
ATOM   73   C CG1 . VAL A 1 237 ? 155.804 148.060 136.171 1.00 15.67  ? 237 VAL A CG1 1 
ATOM   74   C CG2 . VAL A 1 237 ? 155.458 145.926 134.967 1.00 22.58  ? 237 VAL A CG2 1 
ATOM   75   N N   . GLY A 1 238 ? 152.487 148.255 137.483 1.00 12.04  ? 238 GLY A N   1 
ATOM   76   C CA  . GLY A 1 238 ? 151.943 149.311 138.321 1.00 8.92   ? 238 GLY A CA  1 
ATOM   77   C C   . GLY A 1 238 ? 151.406 148.799 139.643 1.00 15.81  ? 238 GLY A C   1 
ATOM   78   O O   . GLY A 1 238 ? 151.587 149.432 140.682 1.00 17.14  ? 238 GLY A O   1 
ATOM   79   N N   . LEU A 1 239 ? 150.730 147.649 139.617 1.00 18.40  ? 239 LEU A N   1 
ATOM   80   C CA  . LEU A 1 239 ? 150.177 147.059 140.831 1.00 12.21  ? 239 LEU A CA  1 
ATOM   81   C C   . LEU A 1 239 ? 151.278 146.697 141.812 1.00 13.09  ? 239 LEU A C   1 
ATOM   82   O O   . LEU A 1 239 ? 151.193 147.008 143.006 1.00 17.17  ? 239 LEU A O   1 
ATOM   83   C CB  . LEU A 1 239 ? 149.353 145.824 140.465 1.00 14.17  ? 239 LEU A CB  1 
ATOM   84   C CG  . LEU A 1 239 ? 148.789 144.926 141.565 1.00 16.28  ? 239 LEU A CG  1 
ATOM   85   C CD1 . LEU A 1 239 ? 147.517 145.507 142.143 1.00 16.46  ? 239 LEU A CD1 1 
ATOM   86   C CD2 . LEU A 1 239 ? 148.541 143.531 141.029 1.00 16.79  ? 239 LEU A CD2 1 
ATOM   87   N N   . PHE A 1 240 ? 152.329 146.037 141.321 1.00 17.12  ? 240 PHE A N   1 
ATOM   88   C CA  . PHE A 1 240 ? 153.450 145.682 142.179 1.00 16.31  ? 240 PHE A CA  1 
ATOM   89   C C   . PHE A 1 240 ? 154.151 146.925 142.704 1.00 20.05  ? 240 PHE A C   1 
ATOM   90   O O   . PHE A 1 240 ? 154.546 146.970 143.871 1.00 22.60  ? 240 PHE A O   1 
ATOM   91   C CB  . PHE A 1 240 ? 154.427 144.785 141.421 1.00 16.31  ? 240 PHE A CB  1 
ATOM   92   C CG  . PHE A 1 240 ? 153.862 143.441 141.062 1.00 20.11  ? 240 PHE A CG  1 
ATOM   93   C CD1 . PHE A 1 240 ? 152.822 142.894 141.790 1.00 20.14  ? 240 PHE A CD1 1 
ATOM   94   C CD2 . PHE A 1 240 ? 154.368 142.725 139.994 1.00 22.12  ? 240 PHE A CD2 1 
ATOM   95   C CE1 . PHE A 1 240 ? 152.299 141.663 141.461 1.00 19.41  ? 240 PHE A CE1 1 
ATOM   96   C CE2 . PHE A 1 240 ? 153.848 141.490 139.661 1.00 22.01  ? 240 PHE A CE2 1 
ATOM   97   C CZ  . PHE A 1 240 ? 152.813 140.960 140.396 1.00 21.48  ? 240 PHE A CZ  1 
ATOM   98   N N   . CYS A 1 241 ? 154.303 147.951 141.862 1.00 20.21  ? 241 CYS A N   1 
ATOM   99   C CA  . CYS A 1 241 ? 154.931 149.190 142.310 1.00 19.16  ? 241 CYS A CA  1 
ATOM   100  C C   . CYS A 1 241 ? 154.112 149.869 143.402 1.00 23.31  ? 241 CYS A C   1 
ATOM   101  O O   . CYS A 1 241 ? 154.671 150.360 144.387 1.00 25.41  ? 241 CYS A O   1 
ATOM   102  C CB  . CYS A 1 241 ? 155.132 150.129 141.123 1.00 17.09  ? 241 CYS A CB  1 
ATOM   103  S SG  . CYS A 1 241 ? 155.807 151.743 141.546 1.00 53.25  ? 241 CYS A SG  1 
ATOM   104  N N   . GLY A 1 242 ? 152.787 149.910 143.246 1.00 17.59  ? 242 GLY A N   1 
ATOM   105  C CA  . GLY A 1 242 ? 151.948 150.526 144.263 1.00 15.50  ? 242 GLY A CA  1 
ATOM   106  C C   . GLY A 1 242 ? 151.952 149.762 145.572 1.00 19.89  ? 242 GLY A C   1 
ATOM   107  O O   . GLY A 1 242 ? 152.043 150.358 146.652 1.00 22.83  ? 242 GLY A O   1 
ATOM   108  N N   . ILE A 1 243 ? 151.858 148.432 145.498 1.00 18.75  ? 243 ILE A N   1 
ATOM   109  C CA  . ILE A 1 243 ? 151.948 147.623 146.709 1.00 18.67  ? 243 ILE A CA  1 
ATOM   110  C C   . ILE A 1 243 ? 153.300 147.825 147.375 1.00 23.14  ? 243 ILE A C   1 
ATOM   111  O O   . ILE A 1 243 ? 153.392 147.941 148.600 1.00 29.41  ? 243 ILE A O   1 
ATOM   112  C CB  . ILE A 1 243 ? 151.693 146.138 146.392 1.00 17.68  ? 243 ILE A CB  1 
ATOM   113  C CG1 . ILE A 1 243 ? 150.291 145.937 145.823 1.00 14.47  ? 243 ILE A CG1 1 
ATOM   114  C CG2 . ILE A 1 243 ? 151.866 145.294 147.637 1.00 20.78  ? 243 ILE A CG2 1 
ATOM   115  C CD1 . ILE A 1 243 ? 150.000 144.513 145.434 1.00 10.23  ? 243 ILE A CD1 1 
ATOM   116  N N   . PHE A 1 244 ? 154.369 147.882 146.578 1.00 22.24  ? 244 PHE A N   1 
ATOM   117  C CA  . PHE A 1 244 ? 155.705 148.085 147.121 1.00 23.44  ? 244 PHE A CA  1 
ATOM   118  C C   . PHE A 1 244 ? 155.828 149.441 147.802 1.00 28.35  ? 244 PHE A C   1 
ATOM   119  O O   . PHE A 1 244 ? 156.440 149.550 148.867 1.00 34.95  ? 244 PHE A O   1 
ATOM   120  C CB  . PHE A 1 244 ? 156.736 147.938 146.002 1.00 24.73  ? 244 PHE A CB  1 
ATOM   121  C CG  . PHE A 1 244 ? 158.156 147.917 146.479 1.00 26.30  ? 244 PHE A CG  1 
ATOM   122  C CD1 . PHE A 1 244 ? 158.632 146.860 147.228 1.00 27.98  ? 244 PHE A CD1 1 
ATOM   123  C CD2 . PHE A 1 244 ? 159.020 148.944 146.161 1.00 28.01  ? 244 PHE A CD2 1 
ATOM   124  C CE1 . PHE A 1 244 ? 159.937 146.838 147.661 1.00 28.29  ? 244 PHE A CE1 1 
ATOM   125  C CE2 . PHE A 1 244 ? 160.328 148.921 146.590 1.00 26.05  ? 244 PHE A CE2 1 
ATOM   126  C CZ  . PHE A 1 244 ? 160.784 147.868 147.343 1.00 26.68  ? 244 PHE A CZ  1 
ATOM   127  N N   . ILE A 1 245 ? 155.246 150.485 147.209 1.00 23.81  ? 245 ILE A N   1 
ATOM   128  C CA  . ILE A 1 245 ? 155.316 151.818 147.806 1.00 21.36  ? 245 ILE A CA  1 
ATOM   129  C C   . ILE A 1 245 ? 154.582 151.845 149.141 1.00 25.50  ? 245 ILE A C   1 
ATOM   130  O O   . ILE A 1 245 ? 155.101 152.345 150.151 1.00 33.04  ? 245 ILE A O   1 
ATOM   131  C CB  . ILE A 1 245 ? 154.752 152.871 146.837 1.00 20.07  ? 245 ILE A CB  1 
ATOM   132  C CG1 . ILE A 1 245 ? 155.696 153.074 145.651 1.00 24.74  ? 245 ILE A CG1 1 
ATOM   133  C CG2 . ILE A 1 245 ? 154.504 154.182 147.559 1.00 21.50  ? 245 ILE A CG2 1 
ATOM   134  C CD1 . ILE A 1 245 ? 155.177 154.049 144.621 1.00 18.96  ? 245 ILE A CD1 1 
ATOM   135  N N   . VAL A 1 246 ? 153.362 151.304 149.170 1.00 25.95  ? 246 VAL A N   1 
ATOM   136  C CA  . VAL A 1 246 ? 152.589 151.344 150.407 1.00 24.12  ? 246 VAL A CA  1 
ATOM   137  C C   . VAL A 1 246 ? 153.243 150.475 151.474 1.00 22.60  ? 246 VAL A C   1 
ATOM   138  O O   . VAL A 1 246 ? 153.250 150.826 152.660 1.00 22.10  ? 246 VAL A O   1 
ATOM   139  C CB  . VAL A 1 246 ? 151.128 150.938 150.151 1.00 22.36  ? 246 VAL A CB  1 
ATOM   140  C CG1 . VAL A 1 246 ? 150.305 151.138 151.406 1.00 16.20  ? 246 VAL A CG1 1 
ATOM   141  C CG2 . VAL A 1 246 ? 150.552 151.764 149.028 1.00 21.54  ? 246 VAL A CG2 1 
ATOM   142  N N   . LEU A 1 247 ? 153.821 149.340 151.075 1.00 24.65  ? 247 LEU A N   1 
ATOM   143  C CA  . LEU A 1 247 ? 154.502 148.485 152.036 1.00 24.40  ? 247 LEU A CA  1 
ATOM   144  C C   . LEU A 1 247 ? 155.793 149.115 152.535 1.00 29.51  ? 247 LEU A C   1 
ATOM   145  O O   . LEU A 1 247 ? 156.167 148.904 153.688 1.00 35.01  ? 247 LEU A O   1 
ATOM   146  C CB  . LEU A 1 247 ? 154.780 147.112 151.426 1.00 24.96  ? 247 LEU A CB  1 
ATOM   147  C CG  . LEU A 1 247 ? 153.571 146.199 151.212 1.00 22.12  ? 247 LEU A CG  1 
ATOM   148  C CD1 . LEU A 1 247 ? 154.014 144.860 150.664 1.00 27.10  ? 247 LEU A CD1 1 
ATOM   149  C CD2 . LEU A 1 247 ? 152.794 146.019 152.497 1.00 19.57  ? 247 LEU A CD2 1 
ATOM   150  N N   . ASN A 1 248 ? 156.483 149.892 151.698 1.00 27.78  ? 248 ASN A N   1 
ATOM   151  C CA  . ASN A 1 248 ? 157.649 150.631 152.172 1.00 27.96  ? 248 ASN A CA  1 
ATOM   152  C C   . ASN A 1 248 ? 157.257 151.684 153.196 1.00 31.98  ? 248 ASN A C   1 
ATOM   153  O O   . ASN A 1 248 ? 157.943 151.856 154.210 1.00 39.43  ? 248 ASN A O   1 
ATOM   154  C CB  . ASN A 1 248 ? 158.373 151.289 151.002 1.00 27.66  ? 248 ASN A CB  1 
ATOM   155  C CG  . ASN A 1 248 ? 159.143 150.303 150.168 1.00 36.50  ? 248 ASN A CG  1 
ATOM   156  O OD1 . ASN A 1 248 ? 159.488 149.217 150.629 1.00 39.37  ? 248 ASN A OD1 1 
ATOM   157  N ND2 . ASN A 1 248 ? 159.430 150.678 148.932 1.00 39.53  ? 248 ASN A ND2 1 
ATOM   158  N N   . ILE A 1 249 ? 156.167 152.410 152.943 1.00 30.83  ? 249 ILE A N   1 
ATOM   159  C CA  . ILE A 1 249 ? 155.711 153.404 153.913 1.00 28.34  ? 249 ILE A CA  1 
ATOM   160  C C   . ILE A 1 249 ? 155.316 152.730 155.222 1.00 32.06  ? 249 ILE A C   1 
ATOM   161  O O   . ILE A 1 249 ? 155.673 153.197 156.314 1.00 34.68  ? 249 ILE A O   1 
ATOM   162  C CB  . ILE A 1 249 ? 154.555 154.233 153.327 1.00 27.55  ? 249 ILE A CB  1 
ATOM   163  C CG1 . ILE A 1 249 ? 155.029 154.993 152.089 1.00 24.79  ? 249 ILE A CG1 1 
ATOM   164  C CG2 . ILE A 1 249 ? 154.015 155.198 154.363 1.00 24.11  ? 249 ILE A CG2 1 
ATOM   165  C CD1 . ILE A 1 249 ? 153.952 155.812 151.430 1.00 27.67  ? 249 ILE A CD1 1 
ATOM   166  N N   . THR A 1 250 ? 154.587 151.615 155.134 1.00 31.43  ? 250 THR A N   1 
ATOM   167  C CA  . THR A 1 250 ? 154.214 150.870 156.332 1.00 27.59  ? 250 THR A CA  1 
ATOM   168  C C   . THR A 1 250 ? 155.445 150.359 157.067 1.00 34.96  ? 250 THR A C   1 
ATOM   169  O O   . THR A 1 250 ? 155.496 150.383 158.300 1.00 43.66  ? 250 THR A O   1 
ATOM   170  C CB  . THR A 1 250 ? 153.299 149.705 155.959 1.00 28.64  ? 250 THR A CB  1 
ATOM   171  O OG1 . THR A 1 250 ? 152.166 150.196 155.234 1.00 33.76  ? 250 THR A OG1 1 
ATOM   172  C CG2 . THR A 1 250 ? 152.820 148.984 157.204 1.00 32.08  ? 250 THR A CG2 1 
ATOM   173  N N   . LEU A 1 251 ? 156.445 149.887 156.322 1.00 36.79  ? 251 LEU A N   1 
ATOM   174  C CA  . LEU A 1 251 ? 157.676 149.388 156.921 1.00 39.33  ? 251 LEU A CA  1 
ATOM   175  C C   . LEU A 1 251 ? 158.414 150.492 157.662 1.00 41.40  ? 251 LEU A C   1 
ATOM   176  O O   . LEU A 1 251 ? 158.895 150.284 158.781 1.00 51.53  ? 251 LEU A O   1 
ATOM   177  C CB  . LEU A 1 251 ? 158.558 148.792 155.827 1.00 40.74  ? 251 LEU A CB  1 
ATOM   178  C CG  . LEU A 1 251 ? 159.685 147.833 156.189 1.00 39.09  ? 251 LEU A CG  1 
ATOM   179  C CD1 . LEU A 1 251 ? 159.119 146.560 156.769 1.00 38.80  ? 251 LEU A CD1 1 
ATOM   180  C CD2 . LEU A 1 251 ? 160.500 147.539 154.947 1.00 37.94  ? 251 LEU A CD2 1 
ATOM   181  N N   . VAL A 1 252 ? 158.510 151.674 157.054 1.00 36.57  ? 252 VAL A N   1 
ATOM   182  C CA  . VAL A 1 252 ? 159.181 152.796 157.704 1.00 38.50  ? 252 VAL A CA  1 
ATOM   183  C C   . VAL A 1 252 ? 158.444 153.186 158.979 1.00 46.93  ? 252 VAL A C   1 
ATOM   184  O O   . VAL A 1 252 ? 159.058 153.400 160.031 1.00 55.82  ? 252 VAL A O   1 
ATOM   185  C CB  . VAL A 1 252 ? 159.303 153.985 156.735 1.00 35.47  ? 252 VAL A CB  1 
ATOM   186  C CG1 . VAL A 1 252 ? 159.783 155.219 157.472 1.00 33.49  ? 252 VAL A CG1 1 
ATOM   187  C CG2 . VAL A 1 252 ? 160.250 153.643 155.600 1.00 37.32  ? 252 VAL A CG2 1 
ATOM   188  N N   . LEU A 1 253 ? 157.111 153.272 158.907 1.00 44.19  ? 253 LEU A N   1 
ATOM   189  C CA  . LEU A 1 253 ? 156.339 153.643 160.090 1.00 44.48  ? 253 LEU A CA  1 
ATOM   190  C C   . LEU A 1 253 ? 156.484 152.608 161.200 1.00 49.87  ? 253 LEU A C   1 
ATOM   191  O O   . LEU A 1 253 ? 156.662 152.963 162.370 1.00 53.85  ? 253 LEU A O   1 
ATOM   192  C CB  . LEU A 1 253 ? 154.870 153.834 159.720 1.00 39.76  ? 253 LEU A CB  1 
ATOM   193  C CG  . LEU A 1 253 ? 154.566 155.022 158.809 1.00 39.97  ? 253 LEU A CG  1 
ATOM   194  C CD1 . LEU A 1 253 ? 153.080 155.109 158.519 1.00 32.47  ? 253 LEU A CD1 1 
ATOM   195  C CD2 . LEU A 1 253 ? 155.068 156.310 159.430 1.00 37.50  ? 253 LEU A CD2 1 
ATOM   196  N N   . ALA A 1 254 ? 156.419 151.321 160.851 1.00 48.69  ? 254 ALA A N   1 
ATOM   197  C CA  . ALA A 1 254 ? 156.545 150.270 161.855 1.00 50.38  ? 254 ALA A CA  1 
ATOM   198  C C   . ALA A 1 254 ? 157.933 150.262 162.479 1.00 59.63  ? 254 ALA A C   1 
ATOM   199  O O   . ALA A 1 254 ? 158.074 150.041 163.687 1.00 70.25  ? 254 ALA A O   1 
ATOM   200  C CB  . ALA A 1 254 ? 156.226 148.911 161.235 1.00 44.56  ? 254 ALA A CB  1 
ATOM   201  N N   . ALA A 1 255 ? 158.972 150.488 161.672 1.00 56.80  ? 255 ALA A N   1 
ATOM   202  C CA  . ALA A 1 255 ? 160.323 150.559 162.214 1.00 61.66  ? 255 ALA A CA  1 
ATOM   203  C C   . ALA A 1 255 ? 160.476 151.748 163.152 1.00 66.35  ? 255 ALA A C   1 
ATOM   204  O O   . ALA A 1 255 ? 161.124 151.641 164.200 1.00 73.08  ? 255 ALA A O   1 
ATOM   205  C CB  . ALA A 1 255 ? 161.341 150.637 161.077 1.00 56.11  ? 255 ALA A CB  1 
ATOM   206  N N   . VAL A 1 256 ? 159.891 152.891 162.792 1.00 62.18  ? 256 VAL A N   1 
ATOM   207  C CA  . VAL A 1 256 ? 160.009 154.079 163.631 1.00 61.79  ? 256 VAL A CA  1 
ATOM   208  C C   . VAL A 1 256 ? 159.284 153.878 164.957 1.00 68.12  ? 256 VAL A C   1 
ATOM   209  O O   . VAL A 1 256 ? 159.820 154.185 166.028 1.00 70.85  ? 256 VAL A O   1 
ATOM   210  C CB  . VAL A 1 256 ? 159.482 155.317 162.883 1.00 57.14  ? 256 VAL A CB  1 
ATOM   211  C CG1 . VAL A 1 256 ? 159.289 156.475 163.843 1.00 60.56  ? 256 VAL A CG1 1 
ATOM   212  C CG2 . VAL A 1 256 ? 160.440 155.710 161.773 1.00 56.54  ? 256 VAL A CG2 1 
ATOM   213  N N   . PHE A 1 257 ? 158.064 153.346 164.911 1.00 69.28  ? 257 PHE A N   1 
ATOM   214  C CA  . PHE A 1 257 ? 157.202 153.324 166.088 1.00 72.42  ? 257 PHE A CA  1 
ATOM   215  C C   . PHE A 1 257 ? 157.266 152.020 166.874 1.00 80.25  ? 257 PHE A C   1 
ATOM   216  O O   . PHE A 1 257 ? 157.411 152.047 168.100 1.00 89.67  ? 257 PHE A O   1 
ATOM   217  C CB  . PHE A 1 257 ? 155.750 153.604 165.680 1.00 67.24  ? 257 PHE A CB  1 
ATOM   218  C CG  . PHE A 1 257 ? 155.507 155.015 165.223 1.00 71.71  ? 257 PHE A CG  1 
ATOM   219  C CD1 . PHE A 1 257 ? 155.396 156.043 166.142 1.00 72.87  ? 257 PHE A CD1 1 
ATOM   220  C CD2 . PHE A 1 257 ? 155.377 155.310 163.877 1.00 72.28  ? 257 PHE A CD2 1 
ATOM   221  C CE1 . PHE A 1 257 ? 155.170 157.341 165.726 1.00 72.71  ? 257 PHE A CE1 1 
ATOM   222  C CE2 . PHE A 1 257 ? 155.150 156.605 163.456 1.00 70.68  ? 257 PHE A CE2 1 
ATOM   223  C CZ  . PHE A 1 257 ? 155.046 157.621 164.381 1.00 72.60  ? 257 PHE A CZ  1 
ATOM   224  N N   . LYS A 1 258 ? 157.162 150.876 166.204 1.00 79.61  ? 258 LYS A N   1 
ATOM   225  C CA  . LYS A 1 258 ? 156.811 149.621 166.864 1.00 83.50  ? 258 LYS A CA  1 
ATOM   226  C C   . LYS A 1 258 ? 157.729 148.485 166.426 1.00 90.34  ? 258 LYS A C   1 
ATOM   227  O O   . LYS A 1 258 ? 157.273 147.420 166.005 1.00 94.90  ? 258 LYS A O   1 
ATOM   228  C CB  . LYS A 1 258 ? 155.348 149.280 166.583 1.00 86.34  ? 258 LYS A CB  1 
ATOM   229  C CG  . LYS A 1 258 ? 154.747 148.208 167.485 1.00 97.01  ? 258 LYS A CG  1 
ATOM   230  C CD  . LYS A 1 258 ? 153.347 147.827 167.026 1.00 95.60  ? 258 LYS A CD  1 
ATOM   231  C CE  . LYS A 1 258 ? 152.795 146.661 167.830 1.00 93.37  ? 258 LYS A CE  1 
ATOM   232  N NZ  . LYS A 1 258 ? 152.723 146.967 169.286 1.00 88.55  ? 258 LYS A NZ  1 
ATOM   233  N N   . LEU A 1 259 ? 159.047 148.681 166.496 1.00 91.22  ? 259 LEU A N   1 
ATOM   234  C CA  . LEU A 1 259 ? 159.955 147.585 166.136 1.00 102.16 ? 259 LEU A CA  1 
ATOM   235  C C   . LEU A 1 259 ? 160.348 146.774 167.369 1.00 108.90 ? 259 LEU A C   1 
ATOM   236  O O   . LEU A 1 259 ? 159.882 145.646 167.551 1.00 106.49 ? 259 LEU A O   1 
ATOM   237  C CB  . LEU A 1 259 ? 161.189 148.147 165.425 1.00 96.11  ? 259 LEU A CB  1 
ATOM   238  C CG  . LEU A 1 259 ? 162.393 147.223 165.235 1.00 95.23  ? 259 LEU A CG  1 
ATOM   239  C CD1 . LEU A 1 259 ? 162.004 145.988 164.451 1.00 89.80  ? 259 LEU A CD1 1 
ATOM   240  C CD2 . LEU A 1 259 ? 163.527 147.962 164.548 1.00 92.53  ? 259 LEU A CD2 1 
ATOM   241  N N   . GLU A 1 260 ? 161.193 147.344 168.229 1.00 113.26 ? 260 GLU A N   1 
ATOM   242  C CA  . GLU A 1 260 ? 161.365 146.865 169.596 1.00 118.75 ? 260 GLU A CA  1 
ATOM   243  C C   . GLU A 1 260 ? 161.586 148.053 170.518 1.00 120.59 ? 260 GLU A C   1 
ATOM   244  O O   . GLU A 1 260 ? 161.298 147.992 171.718 1.00 119.29 ? 260 GLU A O   1 
ATOM   245  C CB  . GLU A 1 260 ? 162.537 145.886 169.691 1.00 124.60 ? 260 GLU A CB  1 
ATOM   246  C CG  . GLU A 1 260 ? 162.198 144.458 169.295 1.00 122.60 ? 260 GLU A CG  1 
ATOM   247  C CD  . GLU A 1 260 ? 161.263 143.784 170.281 1.00 121.78 ? 260 GLU A CD  1 
ATOM   248  O OE1 . GLU A 1 260 ? 161.243 144.193 171.461 1.00 125.29 ? 260 GLU A OE1 1 
ATOM   249  O OE2 . GLU A 1 260 ? 160.545 142.847 169.875 1.00 119.36 ? 260 GLU A OE2 1 
ATOM   250  N N   . THR A 1 261 ? 162.128 149.127 169.938 1.00 125.08 ? 261 THR A N   1 
ATOM   251  C CA  . THR A 1 261 ? 162.500 150.383 170.584 1.00 129.71 ? 261 THR A CA  1 
ATOM   252  C C   . THR A 1 261 ? 163.704 150.221 171.508 1.00 128.75 ? 261 THR A C   1 
ATOM   253  O O   . THR A 1 261 ? 164.249 151.220 171.988 1.00 126.27 ? 261 THR A O   1 
ATOM   254  C CB  . THR A 1 261 ? 161.326 150.989 171.365 1.00 129.82 ? 261 THR A CB  1 
ATOM   255  O OG1 . THR A 1 261 ? 160.995 150.151 172.480 1.00 130.33 ? 261 THR A OG1 1 
ATOM   256  C CG2 . THR A 1 261 ? 160.105 151.149 170.466 1.00 127.39 ? 261 THR A CG2 1 
ATOM   257  N N   . ASP A 1 262 ? 164.134 148.983 171.772 1.00 131.84 ? 262 ASP A N   1 
ATOM   258  C CA  . ASP A 1 262 ? 165.300 148.792 172.633 1.00 132.17 ? 262 ASP A CA  1 
ATOM   259  C C   . ASP A 1 262 ? 166.255 147.674 172.232 1.00 127.60 ? 262 ASP A C   1 
ATOM   260  O O   . ASP A 1 262 ? 167.394 147.684 172.711 1.00 124.58 ? 262 ASP A O   1 
ATOM   261  C CB  . ASP A 1 262 ? 164.848 148.548 174.077 1.00 135.58 ? 262 ASP A CB  1 
ATOM   262  C CG  . ASP A 1 262 ? 163.890 147.379 174.199 1.00 134.04 ? 262 ASP A CG  1 
ATOM   263  O OD1 . ASP A 1 262 ? 163.511 146.805 173.156 1.00 130.76 ? 262 ASP A OD1 1 
ATOM   264  O OD2 . ASP A 1 262 ? 163.518 147.030 175.338 1.00 134.81 ? 262 ASP A OD2 1 
ATOM   265  N N   . ARG A 1 263 ? 165.869 146.710 171.392 1.00 126.29 ? 263 ARG A N   1 
ATOM   266  C CA  . ARG A 1 263 ? 166.666 145.484 171.308 1.00 127.85 ? 263 ARG A CA  1 
ATOM   267  C C   . ARG A 1 263 ? 167.857 145.615 170.360 1.00 126.98 ? 263 ARG A C   1 
ATOM   268  O O   . ARG A 1 263 ? 169.009 145.672 170.802 1.00 130.45 ? 263 ARG A O   1 
ATOM   269  C CB  . ARG A 1 263 ? 165.771 144.314 170.885 1.00 127.47 ? 263 ARG A CB  1 
ATOM   270  C CG  . ARG A 1 263 ? 164.707 143.924 171.901 1.00 130.04 ? 263 ARG A CG  1 
ATOM   271  C CD  . ARG A 1 263 ? 165.322 143.335 173.161 1.00 128.86 ? 263 ARG A CD  1 
ATOM   272  N NE  . ARG A 1 263 ? 164.338 142.622 173.966 1.00 134.79 ? 263 ARG A NE  1 
ATOM   273  C CZ  . ARG A 1 263 ? 163.631 143.168 174.945 1.00 134.97 ? 263 ARG A CZ  1 
ATOM   274  N NH1 . ARG A 1 263 ? 163.780 144.439 175.279 1.00 130.70 ? 263 ARG A NH1 1 
ATOM   275  N NH2 . ARG A 1 263 ? 162.752 142.420 175.607 1.00 135.13 ? 263 ARG A NH2 1 
ATOM   276  N N   . SER A 1 264 ? 167.591 145.693 169.056 1.00 124.74 ? 264 SER A N   1 
ATOM   277  C CA  . SER A 1 264 ? 168.612 145.780 168.012 1.00 119.10 ? 264 SER A CA  1 
ATOM   278  C C   . SER A 1 264 ? 167.910 145.792 166.662 1.00 116.02 ? 264 SER A C   1 
ATOM   279  O O   . SER A 1 264 ? 166.734 145.435 166.554 1.00 118.40 ? 264 SER A O   1 
ATOM   280  C CB  . SER A 1 264 ? 169.615 144.622 168.069 1.00 113.55 ? 264 SER A CB  1 
ATOM   281  O OG  . SER A 1 264 ? 170.607 144.757 167.068 1.00 107.48 ? 264 SER A OG  1 
ATOM   282  N N   . ILE A 1 265 ? 168.646 146.204 165.631 1.00 109.60 ? 265 ILE A N   1 
ATOM   283  C CA  . ILE A 1 265 ? 168.126 146.169 164.268 1.00 101.04 ? 265 ILE A CA  1 
ATOM   284  C C   . ILE A 1 265 ? 169.172 145.590 163.323 1.00 96.43  ? 265 ILE A C   1 
ATOM   285  O O   . ILE A 1 265 ? 168.861 145.222 162.186 1.00 97.49  ? 265 ILE A O   1 
ATOM   286  C CB  . ILE A 1 265 ? 167.684 147.573 163.814 1.00 99.55  ? 265 ILE A CB  1 
ATOM   287  C CG1 . ILE A 1 265 ? 166.710 147.479 162.637 1.00 102.48 ? 265 ILE A CG1 1 
ATOM   288  C CG2 . ILE A 1 265 ? 168.892 148.419 163.443 1.00 90.71  ? 265 ILE A CG2 1 
ATOM   289  C CD1 . ILE A 1 265 ? 166.233 148.823 162.133 1.00 101.59 ? 265 ILE A CD1 1 
ATOM   290  N N   . TRP A 1 266 ? 170.423 145.502 163.790 1.00 93.48  ? 266 TRP A N   1 
ATOM   291  C CA  . TRP A 1 266 ? 171.521 145.166 162.882 1.00 90.58  ? 266 TRP A CA  1 
ATOM   292  C C   . TRP A 1 266 ? 171.426 143.763 162.294 1.00 86.88  ? 266 TRP A C   1 
ATOM   293  O O   . TRP A 1 266 ? 171.601 143.622 161.071 1.00 87.54  ? 266 TRP A O   1 
ATOM   294  C CB  . TRP A 1 266 ? 172.863 145.404 163.577 1.00 92.63  ? 266 TRP A CB  1 
ATOM   295  C CG  . TRP A 1 266 ? 173.251 146.843 163.545 1.00 95.61  ? 266 TRP A CG  1 
ATOM   296  C CD1 . TRP A 1 266 ? 173.472 147.659 164.613 1.00 94.10  ? 266 TRP A CD1 1 
ATOM   297  C CD2 . TRP A 1 266 ? 173.429 147.652 162.377 1.00 92.79  ? 266 TRP A CD2 1 
ATOM   298  N NE1 . TRP A 1 266 ? 173.794 148.923 164.183 1.00 88.35  ? 266 TRP A NE1 1 
ATOM   299  C CE2 . TRP A 1 266 ? 173.773 148.944 162.813 1.00 92.20  ? 266 TRP A CE2 1 
ATOM   300  C CE3 . TRP A 1 266 ? 173.340 147.406 161.003 1.00 86.07  ? 266 TRP A CE3 1 
ATOM   301  C CZ2 . TRP A 1 266 ? 174.025 149.985 161.927 1.00 87.63  ? 266 TRP A CZ2 1 
ATOM   302  C CZ3 . TRP A 1 266 ? 173.589 148.441 160.127 1.00 79.07  ? 266 TRP A CZ3 1 
ATOM   303  C CH2 . TRP A 1 266 ? 173.929 149.713 160.591 1.00 80.79  ? 266 TRP A CH2 1 
ATOM   304  N N   . PRO A 1 267 ? 171.179 142.698 163.065 1.00 86.30  ? 267 PRO A N   1 
ATOM   305  C CA  . PRO A 1 267 ? 171.088 141.368 162.438 1.00 82.72  ? 267 PRO A CA  1 
ATOM   306  C C   . PRO A 1 267 ? 169.944 141.240 161.448 1.00 78.54  ? 267 PRO A C   1 
ATOM   307  O O   . PRO A 1 267 ? 169.971 140.331 160.609 1.00 75.33  ? 267 PRO A O   1 
ATOM   308  C CB  . PRO A 1 267 ? 170.907 140.424 163.633 1.00 90.58  ? 267 PRO A CB  1 
ATOM   309  C CG  . PRO A 1 267 ? 170.363 141.281 164.714 1.00 97.52  ? 267 PRO A CG  1 
ATOM   310  C CD  . PRO A 1 267 ? 171.022 142.611 164.527 1.00 93.79  ? 267 PRO A CD  1 
ATOM   311  N N   . LEU A 1 268 ? 168.942 142.118 161.514 1.00 77.50  ? 268 LEU A N   1 
ATOM   312  C CA  . LEU A 1 268 ? 167.826 142.060 160.575 1.00 71.22  ? 268 LEU A CA  1 
ATOM   313  C C   . LEU A 1 268 ? 168.200 142.690 159.237 1.00 68.09  ? 268 LEU A C   1 
ATOM   314  O O   . LEU A 1 268 ? 168.150 142.028 158.187 1.00 66.46  ? 268 LEU A O   1 
ATOM   315  C CB  . LEU A 1 268 ? 166.603 142.751 161.179 1.00 68.47  ? 268 LEU A CB  1 
ATOM   316  C CG  . LEU A 1 268 ? 165.249 142.220 160.715 1.00 62.10  ? 268 LEU A CG  1 
ATOM   317  C CD1 . LEU A 1 268 ? 165.167 140.725 160.961 1.00 63.15  ? 268 LEU A CD1 1 
ATOM   318  C CD2 . LEU A 1 268 ? 164.137 142.937 161.444 1.00 68.58  ? 268 LEU A CD2 1 
ATOM   319  N N   . ILE A 1 269 ? 168.584 143.969 159.248 1.00 66.80  ? 269 ILE A N   1 
ATOM   320  C CA  . ILE A 1 269 ? 169.085 144.542 158.009 1.00 69.02  ? 269 ILE A CA  1 
ATOM   321  C C   . ILE A 1 269 ? 170.583 144.266 157.981 1.00 67.07  ? 269 ILE A C   1 
ATOM   322  O O   . ILE A 1 269 ? 171.424 145.170 158.025 1.00 69.83  ? 269 ILE A O   1 
ATOM   323  C CB  . ILE A 1 269 ? 168.738 146.044 157.910 1.00 82.49  ? 269 ILE A CB  1 
ATOM   324  C CG1 . ILE A 1 269 ? 169.223 146.655 156.588 1.00 79.64  ? 269 ILE A CG1 1 
ATOM   325  C CG2 . ILE A 1 269 ? 169.212 146.821 159.150 1.00 76.81  ? 269 ILE A CG2 1 
ATOM   326  C CD1 . ILE A 1 269 ? 168.279 146.416 155.422 1.00 62.24  ? 269 ILE A CD1 1 
ATOM   327  N N   . ARG A 1 270 ? 170.902 142.979 157.908 1.00 62.75  ? 270 ARG A N   1 
ATOM   328  C CA  . ARG A 1 270 ? 172.066 142.406 157.252 1.00 59.08  ? 270 ARG A CA  1 
ATOM   329  C C   . ARG A 1 270 ? 171.702 141.120 156.541 1.00 55.14  ? 270 ARG A C   1 
ATOM   330  O O   . ARG A 1 270 ? 172.372 140.749 155.572 1.00 59.68  ? 270 ARG A O   1 
ATOM   331  C CB  . ARG A 1 270 ? 173.187 142.137 158.263 1.00 65.04  ? 270 ARG A CB  1 
ATOM   332  C CG  . ARG A 1 270 ? 174.500 141.701 157.647 1.00 72.29  ? 270 ARG A CG  1 
ATOM   333  C CD  . ARG A 1 270 ? 175.676 142.253 158.427 1.00 77.46  ? 270 ARG A CD  1 
ATOM   334  N NE  . ARG A 1 270 ? 175.558 141.981 159.854 1.00 85.84  ? 270 ARG A NE  1 
ATOM   335  C CZ  . ARG A 1 270 ? 176.438 142.370 160.765 1.00 91.03  ? 270 ARG A CZ  1 
ATOM   336  N NH1 . ARG A 1 270 ? 177.522 143.050 160.432 1.00 94.73  ? 270 ARG A NH1 1 
ATOM   337  N NH2 . ARG A 1 270 ? 176.225 142.069 162.042 1.00 90.60  ? 270 ARG A NH2 1 
ATOM   338  N N   . ILE A 1 271 ? 170.645 140.443 156.987 1.00 55.28  ? 271 ILE A N   1 
ATOM   339  C CA  . ILE A 1 271 ? 170.025 139.359 156.241 1.00 50.29  ? 271 ILE A CA  1 
ATOM   340  C C   . ILE A 1 271 ? 169.177 139.911 155.105 1.00 46.00  ? 271 ILE A C   1 
ATOM   341  O O   . ILE A 1 271 ? 169.204 139.386 153.988 1.00 49.75  ? 271 ILE A O   1 
ATOM   342  C CB  . ILE A 1 271 ? 169.196 138.484 157.197 1.00 52.35  ? 271 ILE A CB  1 
ATOM   343  C CG1 . ILE A 1 271 ? 170.102 137.823 158.236 1.00 60.44  ? 271 ILE A CG1 1 
ATOM   344  C CG2 . ILE A 1 271 ? 168.403 137.447 156.429 1.00 54.15  ? 271 ILE A CG2 1 
ATOM   345  C CD1 . ILE A 1 271 ? 169.357 136.996 159.256 1.00 63.97  ? 271 ILE A CD1 1 
ATOM   346  N N   . TYR A 1 272 ? 168.416 140.981 155.360 1.00 43.69  ? 272 TYR A N   1 
ATOM   347  C CA  . TYR A 1 272 ? 167.552 141.514 154.311 1.00 38.80  ? 272 TYR A CA  1 
ATOM   348  C C   . TYR A 1 272 ? 168.280 142.430 153.335 1.00 40.79  ? 272 TYR A C   1 
ATOM   349  O O   . TYR A 1 272 ? 167.714 142.775 152.286 1.00 39.27  ? 272 TYR A O   1 
ATOM   350  C CB  . TYR A 1 272 ? 166.368 142.246 154.938 1.00 35.17  ? 272 TYR A CB  1 
ATOM   351  C CG  . TYR A 1 272 ? 165.368 141.297 155.545 1.00 36.69  ? 272 TYR A CG  1 
ATOM   352  C CD1 . TYR A 1 272 ? 164.465 140.613 154.747 1.00 33.80  ? 272 TYR A CD1 1 
ATOM   353  C CD2 . TYR A 1 272 ? 165.340 141.067 156.910 1.00 39.62  ? 272 TYR A CD2 1 
ATOM   354  C CE1 . TYR A 1 272 ? 163.559 139.739 155.288 1.00 32.88  ? 272 TYR A CE1 1 
ATOM   355  C CE2 . TYR A 1 272 ? 164.434 140.193 157.462 1.00 39.59  ? 272 TYR A CE2 1 
ATOM   356  C CZ  . TYR A 1 272 ? 163.546 139.532 156.646 1.00 39.40  ? 272 TYR A CZ  1 
ATOM   357  O OH  . TYR A 1 272 ? 162.637 138.660 157.193 1.00 49.13  ? 272 TYR A OH  1 
ATOM   358  N N   . ARG A 1 273 ? 169.518 142.812 153.647 1.00 42.63  ? 273 ARG A N   1 
ATOM   359  C CA  . ARG A 1 273 ? 170.270 143.709 152.779 1.00 35.55  ? 273 ARG A CA  1 
ATOM   360  C C   . ARG A 1 273 ? 170.533 143.078 151.418 1.00 36.54  ? 273 ARG A C   1 
ATOM   361  O O   . ARG A 1 273 ? 170.439 143.751 150.386 1.00 38.01  ? 273 ARG A O   1 
ATOM   362  C CB  . ARG A 1 273 ? 171.579 144.097 153.463 1.00 41.21  ? 273 ARG A CB  1 
ATOM   363  C CG  . ARG A 1 273 ? 172.405 145.131 152.732 1.00 50.98  ? 273 ARG A CG  1 
ATOM   364  C CD  . ARG A 1 273 ? 173.586 145.553 153.584 1.00 53.70  ? 273 ARG A CD  1 
ATOM   365  N NE  . ARG A 1 273 ? 174.410 144.413 153.963 1.00 51.31  ? 273 ARG A NE  1 
ATOM   366  C CZ  . ARG A 1 273 ? 175.353 144.446 154.893 1.00 58.26  ? 273 ARG A CZ  1 
ATOM   367  N NH1 . ARG A 1 273 ? 175.612 145.549 155.576 1.00 60.03  ? 273 ARG A NH1 1 
ATOM   368  N NH2 . ARG A 1 273 ? 176.052 143.344 155.148 1.00 61.16  ? 273 ARG A NH2 1 
ATOM   369  N N   . GLY A 1 274 ? 170.866 141.786 151.392 1.00 36.56  ? 274 GLY A N   1 
ATOM   370  C CA  . GLY A 1 274 ? 171.123 141.125 150.122 1.00 32.76  ? 274 GLY A CA  1 
ATOM   371  C C   . GLY A 1 274 ? 169.894 141.051 149.238 1.00 36.72  ? 274 GLY A C   1 
ATOM   372  O O   . GLY A 1 274 ? 169.972 141.278 148.027 1.00 38.90  ? 274 GLY A O   1 
ATOM   373  N N   . GLY A 1 275 ? 168.743 140.723 149.827 1.00 38.08  ? 275 GLY A N   1 
ATOM   374  C CA  . GLY A 1 275 ? 167.511 140.714 149.058 1.00 32.96  ? 275 GLY A CA  1 
ATOM   375  C C   . GLY A 1 275 ? 167.158 142.084 148.518 1.00 33.94  ? 275 GLY A C   1 
ATOM   376  O O   . GLY A 1 275 ? 166.741 142.221 147.363 1.00 35.99  ? 275 GLY A O   1 
ATOM   377  N N   . PHE A 1 276 ? 167.332 143.123 149.341 1.00 32.64  ? 276 PHE A N   1 
ATOM   378  C CA  . PHE A 1 276 ? 167.080 144.476 148.859 1.00 27.05  ? 276 PHE A CA  1 
ATOM   379  C C   . PHE A 1 276 ? 168.018 144.835 147.715 1.00 28.85  ? 276 PHE A C   1 
ATOM   380  O O   . PHE A 1 276 ? 167.605 145.480 146.745 1.00 31.38  ? 276 PHE A O   1 
ATOM   381  C CB  . PHE A 1 276 ? 167.221 145.486 149.996 1.00 24.31  ? 276 PHE A CB  1 
ATOM   382  C CG  . PHE A 1 276 ? 167.048 146.910 149.555 1.00 28.33  ? 276 PHE A CG  1 
ATOM   383  C CD1 . PHE A 1 276 ? 165.783 147.449 149.397 1.00 27.84  ? 276 PHE A CD1 1 
ATOM   384  C CD2 . PHE A 1 276 ? 168.148 147.706 149.286 1.00 30.58  ? 276 PHE A CD2 1 
ATOM   385  C CE1 . PHE A 1 276 ? 165.620 148.753 148.984 1.00 30.58  ? 276 PHE A CE1 1 
ATOM   386  C CE2 . PHE A 1 276 ? 167.990 149.011 148.871 1.00 33.80  ? 276 PHE A CE2 1 
ATOM   387  C CZ  . PHE A 1 276 ? 166.725 149.536 148.723 1.00 37.34  ? 276 PHE A CZ  1 
ATOM   388  N N   . LEU A 1 277 ? 169.288 144.440 147.817 1.00 29.16  ? 277 LEU A N   1 
ATOM   389  C CA  . LEU A 1 277 ? 170.235 144.709 146.741 1.00 28.18  ? 277 LEU A CA  1 
ATOM   390  C C   . LEU A 1 277 ? 169.833 143.997 145.460 1.00 26.61  ? 277 LEU A C   1 
ATOM   391  O O   . LEU A 1 277 ? 169.963 144.555 144.368 1.00 25.66  ? 277 LEU A O   1 
ATOM   392  C CB  . LEU A 1 277 ? 171.644 144.294 147.155 1.00 30.88  ? 277 LEU A CB  1 
ATOM   393  C CG  . LEU A 1 277 ? 172.397 145.221 148.102 1.00 32.27  ? 277 LEU A CG  1 
ATOM   394  C CD1 . LEU A 1 277 ? 173.852 144.817 148.139 1.00 32.60  ? 277 LEU A CD1 1 
ATOM   395  C CD2 . LEU A 1 277 ? 172.249 146.660 147.662 1.00 30.62  ? 277 LEU A CD2 1 
ATOM   396  N N   . LEU A 1 278 ? 169.352 142.758 145.571 1.00 28.65  ? 278 LEU A N   1 
ATOM   397  C CA  . LEU A 1 278 ? 168.914 142.030 144.383 1.00 26.39  ? 278 LEU A CA  1 
ATOM   398  C C   . LEU A 1 278 ? 167.713 142.708 143.729 1.00 26.09  ? 278 LEU A C   1 
ATOM   399  O O   . LEU A 1 278 ? 167.655 142.843 142.499 1.00 26.53  ? 278 LEU A O   1 
ATOM   400  C CB  . LEU A 1 278 ? 168.587 140.585 144.753 1.00 27.79  ? 278 LEU A CB  1 
ATOM   401  C CG  . LEU A 1 278 ? 168.490 139.566 143.620 1.00 33.96  ? 278 LEU A CG  1 
ATOM   402  C CD1 . LEU A 1 278 ? 169.286 138.327 143.977 1.00 41.88  ? 278 LEU A CD1 1 
ATOM   403  C CD2 . LEU A 1 278 ? 167.042 139.204 143.351 1.00 38.37  ? 278 LEU A CD2 1 
ATOM   404  N N   . ILE A 1 279 ? 166.750 143.152 144.539 1.00 26.32  ? 279 ILE A N   1 
ATOM   405  C CA  . ILE A 1 279 ? 165.570 143.828 143.998 1.00 24.73  ? 279 ILE A CA  1 
ATOM   406  C C   . ILE A 1 279 ? 165.963 145.139 143.327 1.00 24.80  ? 279 ILE A C   1 
ATOM   407  O O   . ILE A 1 279 ? 165.497 145.463 142.225 1.00 27.98  ? 279 ILE A O   1 
ATOM   408  C CB  . ILE A 1 279 ? 164.534 144.055 145.111 1.00 26.94  ? 279 ILE A CB  1 
ATOM   409  C CG1 . ILE A 1 279 ? 164.075 142.717 145.681 1.00 31.30  ? 279 ILE A CG1 1 
ATOM   410  C CG2 . ILE A 1 279 ? 163.355 144.847 144.587 1.00 26.81  ? 279 ILE A CG2 1 
ATOM   411  C CD1 . ILE A 1 279 ? 163.613 142.808 147.097 1.00 30.17  ? 279 ILE A CD1 1 
ATOM   412  N N   . GLU A 1 280 ? 166.824 145.915 143.988 1.00 24.47  ? 280 GLU A N   1 
ATOM   413  C CA  . GLU A 1 280 ? 167.303 147.166 143.412 1.00 19.70  ? 280 GLU A CA  1 
ATOM   414  C C   . GLU A 1 280 ? 168.055 146.919 142.114 1.00 20.69  ? 280 GLU A C   1 
ATOM   415  O O   . GLU A 1 280 ? 167.912 147.679 141.151 1.00 25.45  ? 280 GLU A O   1 
ATOM   416  C CB  . GLU A 1 280 ? 168.194 147.886 144.418 1.00 18.99  ? 280 GLU A CB  1 
ATOM   417  C CG  . GLU A 1 280 ? 169.097 148.936 143.815 1.00 19.56  ? 280 GLU A CG  1 
ATOM   418  C CD  . GLU A 1 280 ? 170.130 149.433 144.797 1.00 31.18  ? 280 GLU A CD  1 
ATOM   419  O OE1 . GLU A 1 280 ? 170.183 148.896 145.921 1.00 35.81  ? 280 GLU A OE1 1 
ATOM   420  O OE2 . GLU A 1 280 ? 170.890 150.358 144.450 1.00 29.21  ? 280 GLU A OE2 1 
ATOM   421  N N   . PHE A 1 281 ? 168.870 145.865 142.075 1.00 21.84  ? 281 PHE A N   1 
ATOM   422  C CA  . PHE A 1 281 ? 169.604 145.535 140.863 1.00 16.79  ? 281 PHE A CA  1 
ATOM   423  C C   . PHE A 1 281 ? 168.660 145.185 139.724 1.00 18.77  ? 281 PHE A C   1 
ATOM   424  O O   . PHE A 1 281 ? 168.883 145.596 138.584 1.00 18.66  ? 281 PHE A O   1 
ATOM   425  C CB  . PHE A 1 281 ? 170.571 144.384 141.137 1.00 19.90  ? 281 PHE A CB  1 
ATOM   426  C CG  . PHE A 1 281 ? 171.201 143.819 139.902 1.00 28.01  ? 281 PHE A CG  1 
ATOM   427  C CD1 . PHE A 1 281 ? 172.259 144.466 139.290 1.00 25.53  ? 281 PHE A CD1 1 
ATOM   428  C CD2 . PHE A 1 281 ? 170.734 142.641 139.351 1.00 26.43  ? 281 PHE A CD2 1 
ATOM   429  C CE1 . PHE A 1 281 ? 172.831 143.950 138.155 1.00 22.01  ? 281 PHE A CE1 1 
ATOM   430  C CE2 . PHE A 1 281 ? 171.303 142.125 138.216 1.00 21.83  ? 281 PHE A CE2 1 
ATOM   431  C CZ  . PHE A 1 281 ? 172.350 142.778 137.619 1.00 21.15  ? 281 PHE A CZ  1 
ATOM   432  N N   . LEU A 1 282 ? 167.599 144.427 140.010 1.00 20.54  ? 282 LEU A N   1 
ATOM   433  C CA  . LEU A 1 282 ? 166.635 144.097 138.961 1.00 18.76  ? 282 LEU A CA  1 
ATOM   434  C C   . LEU A 1 282 ? 165.909 145.339 138.453 1.00 19.96  ? 282 LEU A C   1 
ATOM   435  O O   . LEU A 1 282 ? 165.685 145.486 137.245 1.00 18.93  ? 282 LEU A O   1 
ATOM   436  C CB  . LEU A 1 282 ? 165.633 143.063 139.468 1.00 21.81  ? 282 LEU A CB  1 
ATOM   437  C CG  . LEU A 1 282 ? 166.173 141.661 139.745 1.00 25.64  ? 282 LEU A CG  1 
ATOM   438  C CD1 . LEU A 1 282 ? 165.055 140.745 140.200 1.00 20.69  ? 282 LEU A CD1 1 
ATOM   439  C CD2 . LEU A 1 282 ? 166.862 141.102 138.514 1.00 25.91  ? 282 LEU A CD2 1 
ATOM   440  N N   . PHE A 1 283 ? 165.535 146.246 139.359 1.00 20.28  ? 283 PHE A N   1 
ATOM   441  C CA  . PHE A 1 283 ? 164.874 147.481 138.939 1.00 17.35  ? 283 PHE A CA  1 
ATOM   442  C C   . PHE A 1 283 ? 165.796 148.336 138.072 1.00 20.04  ? 283 PHE A C   1 
ATOM   443  O O   . PHE A 1 283 ? 165.404 148.817 136.998 1.00 23.22  ? 283 PHE A O   1 
ATOM   444  C CB  . PHE A 1 283 ? 164.407 148.256 140.170 1.00 19.54  ? 283 PHE A CB  1 
ATOM   445  C CG  . PHE A 1 283 ? 163.743 149.560 139.849 1.00 32.73  ? 283 PHE A CG  1 
ATOM   446  C CD1 . PHE A 1 283 ? 162.480 149.589 139.284 1.00 33.85  ? 283 PHE A CD1 1 
ATOM   447  C CD2 . PHE A 1 283 ? 164.376 150.761 140.121 1.00 30.41  ? 283 PHE A CD2 1 
ATOM   448  C CE1 . PHE A 1 283 ? 161.865 150.790 138.987 1.00 30.44  ? 283 PHE A CE1 1 
ATOM   449  C CE2 . PHE A 1 283 ? 163.764 151.963 139.826 1.00 28.47  ? 283 PHE A CE2 1 
ATOM   450  C CZ  . PHE A 1 283 ? 162.508 151.975 139.257 1.00 27.37  ? 283 PHE A CZ  1 
ATOM   451  N N   . LEU A 1 284 ? 167.040 148.520 138.514 1.00 17.50  ? 284 LEU A N   1 
ATOM   452  C CA  . LEU A 1 284 ? 167.990 149.302 137.736 1.00 15.29  ? 284 LEU A CA  1 
ATOM   453  C C   . LEU A 1 284 ? 168.341 148.614 136.425 1.00 14.79  ? 284 LEU A C   1 
ATOM   454  O O   . LEU A 1 284 ? 168.648 149.286 135.439 1.00 16.44  ? 284 LEU A O   1 
ATOM   455  C CB  . LEU A 1 284 ? 169.246 149.568 138.562 1.00 14.42  ? 284 LEU A CB  1 
ATOM   456  C CG  . LEU A 1 284 ? 169.030 150.404 139.823 1.00 13.10  ? 284 LEU A CG  1 
ATOM   457  C CD1 . LEU A 1 284 ? 170.335 150.615 140.561 1.00 13.44  ? 284 LEU A CD1 1 
ATOM   458  C CD2 . LEU A 1 284 ? 168.376 151.733 139.487 1.00 11.92  ? 284 LEU A CD2 1 
ATOM   459  N N   . LEU A 1 285 ? 168.282 147.283 136.383 1.00 15.30  ? 285 LEU A N   1 
ATOM   460  C CA  . LEU A 1 285 ? 168.521 146.562 135.141 1.00 17.32  ? 285 LEU A CA  1 
ATOM   461  C C   . LEU A 1 285 ? 167.367 146.736 134.165 1.00 18.53  ? 285 LEU A C   1 
ATOM   462  O O   . LEU A 1 285 ? 167.584 146.787 132.951 1.00 20.34  ? 285 LEU A O   1 
ATOM   463  C CB  . LEU A 1 285 ? 168.756 145.086 135.447 1.00 20.70  ? 285 LEU A CB  1 
ATOM   464  C CG  . LEU A 1 285 ? 169.255 144.195 134.316 1.00 26.06  ? 285 LEU A CG  1 
ATOM   465  C CD1 . LEU A 1 285 ? 170.636 144.627 133.871 1.00 27.10  ? 285 LEU A CD1 1 
ATOM   466  C CD2 . LEU A 1 285 ? 169.264 142.758 134.781 1.00 29.43  ? 285 LEU A CD2 1 
ATOM   467  N N   . GLY A 1 286 ? 166.137 146.827 134.672 1.00 16.58  ? 286 GLY A N   1 
ATOM   468  C CA  . GLY A 1 286 ? 165.030 147.221 133.815 1.00 13.90  ? 286 GLY A CA  1 
ATOM   469  C C   . GLY A 1 286 ? 165.212 148.617 133.252 1.00 17.16  ? 286 GLY A C   1 
ATOM   470  O O   . GLY A 1 286 ? 164.936 148.869 132.075 1.00 21.92  ? 286 GLY A O   1 
ATOM   471  N N   . ILE A 1 287 ? 165.694 149.543 134.083 1.00 16.00  ? 287 ILE A N   1 
ATOM   472  C CA  . ILE A 1 287 ? 165.993 150.888 133.588 1.00 16.24  ? 287 ILE A CA  1 
ATOM   473  C C   . ILE A 1 287 ? 167.081 150.834 132.519 1.00 19.63  ? 287 ILE A C   1 
ATOM   474  O O   . ILE A 1 287 ? 167.024 151.552 131.513 1.00 25.10  ? 287 ILE A O   1 
ATOM   475  C CB  . ILE A 1 287 ? 166.387 151.820 134.748 1.00 18.04  ? 287 ILE A CB  1 
ATOM   476  C CG1 . ILE A 1 287 ? 165.248 151.940 135.757 1.00 17.64  ? 287 ILE A CG1 1 
ATOM   477  C CG2 . ILE A 1 287 ? 166.744 153.195 134.225 1.00 17.91  ? 287 ILE A CG2 1 
ATOM   478  C CD1 . ILE A 1 287 ? 165.543 152.902 136.877 1.00 17.38  ? 287 ILE A CD1 1 
ATOM   479  N N   . ASN A 1 288 ? 168.091 149.984 132.724 1.00 17.37  ? 288 ASN A N   1 
ATOM   480  C CA  . ASN A 1 288 ? 169.148 149.813 131.730 1.00 13.30  ? 288 ASN A CA  1 
ATOM   481  C C   . ASN A 1 288 ? 168.597 149.283 130.419 1.00 21.62  ? 288 ASN A C   1 
ATOM   482  O O   . ASN A 1 288 ? 169.002 149.731 129.343 1.00 25.34  ? 288 ASN A O   1 
ATOM   483  C CB  . ASN A 1 288 ? 170.225 148.866 132.254 1.00 13.32  ? 288 ASN A CB  1 
ATOM   484  C CG  . ASN A 1 288 ? 171.208 149.547 133.165 1.00 17.48  ? 288 ASN A CG  1 
ATOM   485  O OD1 . ASN A 1 288 ? 171.420 149.116 134.294 1.00 24.78  ? 288 ASN A OD1 1 
ATOM   486  N ND2 . ASN A 1 288 ? 171.826 150.612 132.680 1.00 16.28  ? 288 ASN A ND2 1 
ATOM   487  N N   . THR A 1 289 ? 167.701 148.299 130.488 1.00 24.73  ? 289 THR A N   1 
ATOM   488  C CA  . THR A 1 289 ? 167.105 147.752 129.275 1.00 21.76  ? 289 THR A CA  1 
ATOM   489  C C   . THR A 1 289 ? 166.308 148.814 128.532 1.00 27.07  ? 289 THR A C   1 
ATOM   490  O O   . THR A 1 289 ? 166.378 148.907 127.301 1.00 34.13  ? 289 THR A O   1 
ATOM   491  C CB  . THR A 1 289 ? 166.215 146.559 129.614 1.00 21.50  ? 289 THR A CB  1 
ATOM   492  O OG1 . THR A 1 289 ? 166.981 145.578 130.319 1.00 32.70  ? 289 THR A OG1 1 
ATOM   493  C CG2 . THR A 1 289 ? 165.661 145.940 128.349 1.00 32.68  ? 289 THR A CG2 1 
ATOM   494  N N   . TYR A 1 290 ? 165.550 149.633 129.266 1.00 23.51  ? 290 TYR A N   1 
ATOM   495  C CA  . TYR A 1 290 ? 164.827 150.727 128.624 1.00 23.26  ? 290 TYR A CA  1 
ATOM   496  C C   . TYR A 1 290 ? 165.783 151.704 127.949 1.00 26.98  ? 290 TYR A C   1 
ATOM   497  O O   . TYR A 1 290 ? 165.547 152.132 126.813 1.00 34.63  ? 290 TYR A O   1 
ATOM   498  C CB  . TYR A 1 290 ? 163.956 151.456 129.645 1.00 26.03  ? 290 TYR A CB  1 
ATOM   499  C CG  . TYR A 1 290 ? 163.374 152.748 129.125 1.00 31.65  ? 290 TYR A CG  1 
ATOM   500  C CD1 . TYR A 1 290 ? 162.290 152.744 128.262 1.00 32.52  ? 290 TYR A CD1 1 
ATOM   501  C CD2 . TYR A 1 290 ? 163.907 153.972 129.499 1.00 37.54  ? 290 TYR A CD2 1 
ATOM   502  C CE1 . TYR A 1 290 ? 161.756 153.919 127.786 1.00 41.03  ? 290 TYR A CE1 1 
ATOM   503  C CE2 . TYR A 1 290 ? 163.381 155.153 129.026 1.00 40.91  ? 290 TYR A CE2 1 
ATOM   504  C CZ  . TYR A 1 290 ? 162.305 155.121 128.169 1.00 49.74  ? 290 TYR A CZ  1 
ATOM   505  O OH  . TYR A 1 290 ? 161.774 156.297 127.694 1.00 63.02  ? 290 TYR A OH  1 
ATOM   506  N N   . GLY A 1 291 ? 166.866 152.070 128.635 1.00 27.50  ? 291 GLY A N   1 
ATOM   507  C CA  . GLY A 1 291 ? 167.820 153.000 128.051 1.00 25.18  ? 291 GLY A CA  1 
ATOM   508  C C   . GLY A 1 291 ? 168.510 152.441 126.822 1.00 30.46  ? 291 GLY A C   1 
ATOM   509  O O   . GLY A 1 291 ? 168.719 153.154 125.838 1.00 36.14  ? 291 GLY A O   1 
ATOM   510  N N   . TRP A 1 292 ? 168.880 151.160 126.864 1.00 29.92  ? 292 TRP A N   1 
ATOM   511  C CA  . TRP A 1 292 ? 169.484 150.515 125.704 1.00 30.60  ? 292 TRP A CA  1 
ATOM   512  C C   . TRP A 1 292 ? 168.513 150.467 124.534 1.00 38.69  ? 292 TRP A C   1 
ATOM   513  O O   . TRP A 1 292 ? 168.899 150.719 123.387 1.00 41.76  ? 292 TRP A O   1 
ATOM   514  C CB  . TRP A 1 292 ? 169.944 149.104 126.066 1.00 29.51  ? 292 TRP A CB  1 
ATOM   515  C CG  . TRP A 1 292 ? 170.972 149.050 127.151 1.00 31.02  ? 292 TRP A CG  1 
ATOM   516  C CD1 . TRP A 1 292 ? 171.849 150.031 127.497 1.00 30.35  ? 292 TRP A CD1 1 
ATOM   517  C CD2 . TRP A 1 292 ? 171.223 147.956 128.040 1.00 24.62  ? 292 TRP A CD2 1 
ATOM   518  N NE1 . TRP A 1 292 ? 172.633 149.618 128.542 1.00 24.35  ? 292 TRP A NE1 1 
ATOM   519  C CE2 . TRP A 1 292 ? 172.270 148.345 128.892 1.00 23.61  ? 292 TRP A CE2 1 
ATOM   520  C CE3 . TRP A 1 292 ? 170.667 146.684 128.194 1.00 25.09  ? 292 TRP A CE3 1 
ATOM   521  C CZ2 . TRP A 1 292 ? 172.769 147.512 129.887 1.00 24.38  ? 292 TRP A CZ2 1 
ATOM   522  C CZ3 . TRP A 1 292 ? 171.163 145.860 129.179 1.00 25.43  ? 292 TRP A CZ3 1 
ATOM   523  C CH2 . TRP A 1 292 ? 172.204 146.276 130.014 1.00 24.15  ? 292 TRP A CH2 1 
ATOM   524  N N   . ARG A 1 293 ? 167.247 150.135 124.803 1.00 41.35  ? 293 ARG A N   1 
ATOM   525  C CA  . ARG A 1 293 ? 166.254 150.069 123.737 1.00 38.22  ? 293 ARG A CA  1 
ATOM   526  C C   . ARG A 1 293 ? 166.028 151.434 123.102 1.00 37.57  ? 293 ARG A C   1 
ATOM   527  O O   . ARG A 1 293 ? 165.932 151.544 121.875 1.00 43.63  ? 293 ARG A O   1 
ATOM   528  C CB  . ARG A 1 293 ? 164.940 149.512 124.281 1.00 39.99  ? 293 ARG A CB  1 
ATOM   529  C CG  . ARG A 1 293 ? 163.950 149.094 123.210 1.00 52.34  ? 293 ARG A CG  1 
ATOM   530  C CD  . ARG A 1 293 ? 164.192 147.663 122.766 1.00 62.13  ? 293 ARG A CD  1 
ATOM   531  N NE  . ARG A 1 293 ? 163.927 146.712 123.839 1.00 65.89  ? 293 ARG A NE  1 
ATOM   532  C CZ  . ARG A 1 293 ? 164.031 145.396 123.717 1.00 74.69  ? 293 ARG A CZ  1 
ATOM   533  N NH1 . ARG A 1 293 ? 164.397 144.835 122.577 1.00 73.23  ? 293 ARG A NH1 1 
ATOM   534  N NH2 . ARG A 1 293 ? 163.761 144.624 124.765 1.00 71.95  ? 293 ARG A NH2 1 
ATOM   535  N N   . GLN A 1 294 ? 165.936 152.485 123.919 1.00 36.52  ? 294 GLN A N   1 
ATOM   536  C CA  . GLN A 1 294 ? 165.701 153.816 123.367 1.00 38.38  ? 294 GLN A CA  1 
ATOM   537  C C   . GLN A 1 294 ? 166.925 154.341 122.629 1.00 43.32  ? 294 GLN A C   1 
ATOM   538  O O   . GLN A 1 294 ? 166.795 154.982 121.581 1.00 48.11  ? 294 GLN A O   1 
ATOM   539  C CB  . GLN A 1 294 ? 165.289 154.783 124.475 1.00 37.79  ? 294 GLN A CB  1 
ATOM   540  C CG  . GLN A 1 294 ? 163.955 154.451 125.107 1.00 45.67  ? 294 GLN A CG  1 
ATOM   541  C CD  . GLN A 1 294 ? 162.828 154.401 124.097 1.00 58.10  ? 294 GLN A CD  1 
ATOM   542  O OE1 . GLN A 1 294 ? 161.996 153.494 124.120 1.00 60.54  ? 294 GLN A OE1 1 
ATOM   543  N NE2 . GLN A 1 294 ? 162.791 155.382 123.204 1.00 63.90  ? 294 GLN A NE2 1 
ATOM   544  N N   . ALA A 1 295 ? 168.121 154.082 123.156 1.00 42.21  ? 295 ALA A N   1 
ATOM   545  C CA  . ALA A 1 295 ? 169.342 154.594 122.553 1.00 37.71  ? 295 ALA A CA  1 
ATOM   546  C C   . ALA A 1 295 ? 169.744 153.852 121.288 1.00 43.86  ? 295 ALA A C   1 
ATOM   547  O O   . ALA A 1 295 ? 170.631 154.323 120.571 1.00 48.68  ? 295 ALA A O   1 
ATOM   548  C CB  . ALA A 1 295 ? 170.486 154.534 123.565 1.00 39.41  ? 295 ALA A CB  1 
ATOM   549  N N   . GLY A 1 296 ? 169.115 152.721 120.988 1.00 41.48  ? 296 GLY A N   1 
ATOM   550  C CA  . GLY A 1 296 ? 169.488 151.932 119.835 1.00 35.74  ? 296 GLY A CA  1 
ATOM   551  C C   . GLY A 1 296 ? 170.596 150.933 120.070 1.00 44.58  ? 296 GLY A C   1 
ATOM   552  O O   . GLY A 1 296 ? 171.067 150.320 119.105 1.00 52.22  ? 296 GLY A O   1 
ATOM   553  N N   . VAL A 1 297 ? 171.032 150.751 121.315 1.00 46.03  ? 297 VAL A N   1 
ATOM   554  C CA  . VAL A 1 297 ? 172.064 149.765 121.615 1.00 44.36  ? 297 VAL A CA  1 
ATOM   555  C C   . VAL A 1 297 ? 171.458 148.373 121.504 1.00 48.25  ? 297 VAL A C   1 
ATOM   556  O O   . VAL A 1 297 ? 170.472 148.053 122.178 1.00 52.11  ? 297 VAL A O   1 
ATOM   557  C CB  . VAL A 1 297 ? 172.664 150.006 123.005 1.00 40.75  ? 297 VAL A CB  1 
ATOM   558  C CG1 . VAL A 1 297 ? 173.641 148.904 123.354 1.00 39.63  ? 297 VAL A CG1 1 
ATOM   559  C CG2 . VAL A 1 297 ? 173.347 151.358 123.050 1.00 42.79  ? 297 VAL A CG2 1 
ATOM   560  N N   . ASN A 1 298 ? 172.049 147.537 120.654 1.00 48.23  ? 298 ASN A N   1 
ATOM   561  C CA  . ASN A 1 298 ? 171.490 146.222 120.340 1.00 48.87  ? 298 ASN A CA  1 
ATOM   562  C C   . ASN A 1 298 ? 171.948 145.204 121.385 1.00 44.25  ? 298 ASN A C   1 
ATOM   563  O O   . ASN A 1 298 ? 172.752 144.309 121.124 1.00 49.46  ? 298 ASN A O   1 
ATOM   564  C CB  . ASN A 1 298 ? 171.897 145.802 118.933 1.00 49.47  ? 298 ASN A CB  1 
ATOM   565  C CG  . ASN A 1 298 ? 171.082 144.639 118.410 1.00 53.80  ? 298 ASN A CG  1 
ATOM   566  O OD1 . ASN A 1 298 ? 170.464 143.900 119.175 1.00 58.03  ? 298 ASN A OD1 1 
ATOM   567  N ND2 . ASN A 1 298 ? 171.079 144.468 117.094 1.00 45.92  ? 298 ASN A ND2 1 
ATOM   568  N N   . HIS A 1 299 ? 171.403 145.350 122.594 1.00 44.43  ? 299 HIS A N   1 
ATOM   569  C CA  . HIS A 1 299 ? 171.776 144.440 123.671 1.00 46.87  ? 299 HIS A CA  1 
ATOM   570  C C   . HIS A 1 299 ? 171.256 143.028 123.442 1.00 52.07  ? 299 HIS A C   1 
ATOM   571  O O   . HIS A 1 299 ? 171.751 142.091 124.073 1.00 51.25  ? 299 HIS A O   1 
ATOM   572  C CB  . HIS A 1 299 ? 171.284 144.971 125.020 1.00 41.96  ? 299 HIS A CB  1 
ATOM   573  C CG  . HIS A 1 299 ? 169.811 144.813 125.239 1.00 42.27  ? 299 HIS A CG  1 
ATOM   574  N ND1 . HIS A 1 299 ? 168.896 145.773 124.867 1.00 44.94  ? 299 HIS A ND1 1 
ATOM   575  C CD2 . HIS A 1 299 ? 169.098 143.815 125.811 1.00 39.88  ? 299 HIS A CD2 1 
ATOM   576  C CE1 . HIS A 1 299 ? 167.681 145.368 125.188 1.00 43.35  ? 299 HIS A CE1 1 
ATOM   577  N NE2 . HIS A 1 299 ? 167.776 144.183 125.763 1.00 42.49  ? 299 HIS A NE2 1 
ATOM   578  N N   . VAL A 1 300 ? 170.272 142.855 122.559 1.00 52.19  ? 300 VAL A N   1 
ATOM   579  C CA  . VAL A 1 300 ? 169.809 141.514 122.217 1.00 52.48  ? 300 VAL A CA  1 
ATOM   580  C C   . VAL A 1 300 ? 170.896 140.755 121.467 1.00 55.53  ? 300 VAL A C   1 
ATOM   581  O O   . VAL A 1 300 ? 171.186 139.591 121.767 1.00 57.95  ? 300 VAL A O   1 
ATOM   582  C CB  . VAL A 1 300 ? 168.506 141.592 121.402 1.00 57.10  ? 300 VAL A CB  1 
ATOM   583  C CG1 . VAL A 1 300 ? 168.079 140.212 120.944 1.00 62.46  ? 300 VAL A CG1 1 
ATOM   584  C CG2 . VAL A 1 300 ? 167.409 142.245 122.224 1.00 63.22  ? 300 VAL A CG2 1 
ATOM   585  N N   . LEU A 1 301 ? 171.515 141.404 120.480 1.00 54.45  ? 301 LEU A N   1 
ATOM   586  C CA  . LEU A 1 301 ? 172.570 140.755 119.710 1.00 49.77  ? 301 LEU A CA  1 
ATOM   587  C C   . LEU A 1 301 ? 173.849 140.619 120.524 1.00 49.78  ? 301 LEU A C   1 
ATOM   588  O O   . LEU A 1 301 ? 174.562 139.617 120.405 1.00 55.31  ? 301 LEU A O   1 
ATOM   589  C CB  . LEU A 1 301 ? 172.830 141.536 118.422 1.00 48.60  ? 301 LEU A CB  1 
ATOM   590  C CG  . LEU A 1 301 ? 174.009 141.112 117.548 1.00 50.67  ? 301 LEU A CG  1 
ATOM   591  C CD1 . LEU A 1 301 ? 173.579 141.028 116.096 1.00 50.28  ? 301 LEU A CD1 1 
ATOM   592  C CD2 . LEU A 1 301 ? 175.162 142.087 117.700 1.00 51.94  ? 301 LEU A CD2 1 
ATOM   593  N N   . ILE A 1 302 ? 174.159 141.620 121.350 1.00 48.38  ? 302 ILE A N   1 
ATOM   594  C CA  . ILE A 1 302 ? 175.382 141.582 122.147 1.00 51.39  ? 302 ILE A CA  1 
ATOM   595  C C   . ILE A 1 302 ? 175.330 140.443 123.157 1.00 52.02  ? 302 ILE A C   1 
ATOM   596  O O   . ILE A 1 302 ? 176.307 139.706 123.335 1.00 56.37  ? 302 ILE A O   1 
ATOM   597  C CB  . ILE A 1 302 ? 175.609 142.942 122.831 1.00 44.69  ? 302 ILE A CB  1 
ATOM   598  C CG1 . ILE A 1 302 ? 175.839 144.030 121.783 1.00 40.94  ? 302 ILE A CG1 1 
ATOM   599  C CG2 . ILE A 1 302 ? 176.785 142.874 123.775 1.00 39.27  ? 302 ILE A CG2 1 
ATOM   600  C CD1 . ILE A 1 302 ? 176.019 145.406 122.370 1.00 37.56  ? 302 ILE A CD1 1 
ATOM   601  N N   . PHE A 1 303 ? 174.191 140.271 123.825 1.00 51.12  ? 303 PHE A N   1 
ATOM   602  C CA  . PHE A 1 303 ? 174.011 139.185 124.780 1.00 51.14  ? 303 PHE A CA  1 
ATOM   603  C C   . PHE A 1 303 ? 173.701 137.853 124.115 1.00 57.99  ? 303 PHE A C   1 
ATOM   604  O O   . PHE A 1 303 ? 173.488 136.864 124.825 1.00 56.82  ? 303 PHE A O   1 
ATOM   605  C CB  . PHE A 1 303 ? 172.891 139.523 125.767 1.00 46.87  ? 303 PHE A CB  1 
ATOM   606  C CG  . PHE A 1 303 ? 173.307 140.446 126.870 1.00 47.36  ? 303 PHE A CG  1 
ATOM   607  C CD1 . PHE A 1 303 ? 174.029 139.973 127.946 1.00 38.14  ? 303 PHE A CD1 1 
ATOM   608  C CD2 . PHE A 1 303 ? 172.959 141.784 126.843 1.00 51.34  ? 303 PHE A CD2 1 
ATOM   609  C CE1 . PHE A 1 303 ? 174.406 140.817 128.960 1.00 37.76  ? 303 PHE A CE1 1 
ATOM   610  C CE2 . PHE A 1 303 ? 173.333 142.632 127.860 1.00 36.93  ? 303 PHE A CE2 1 
ATOM   611  C CZ  . PHE A 1 303 ? 174.056 142.148 128.918 1.00 32.55  ? 303 PHE A CZ  1 
ATOM   612  N N   . GLU A 1 304 ? 173.661 137.806 122.783 1.00 58.77  ? 304 GLU A N   1 
ATOM   613  C CA  . GLU A 1 304 ? 173.322 136.600 122.028 1.00 59.91  ? 304 GLU A CA  1 
ATOM   614  C C   . GLU A 1 304 ? 171.932 136.091 122.414 1.00 61.75  ? 304 GLU A C   1 
ATOM   615  O O   . GLU A 1 304 ? 171.760 134.987 122.932 1.00 69.84  ? 304 GLU A O   1 
ATOM   616  C CB  . GLU A 1 304 ? 174.385 135.511 122.216 1.00 66.26  ? 304 GLU A CB  1 
ATOM   617  C CG  . GLU A 1 304 ? 175.821 135.999 122.094 1.00 65.83  ? 304 GLU A CG  1 
ATOM   618  C CD  . GLU A 1 304 ? 176.142 136.562 120.723 1.00 73.57  ? 304 GLU A CD  1 
ATOM   619  O OE1 . GLU A 1 304 ? 175.455 136.197 119.747 1.00 76.42  ? 304 GLU A OE1 1 
ATOM   620  O OE2 . GLU A 1 304 ? 177.088 137.371 120.622 1.00 74.54  ? 304 GLU A OE2 1 
ATOM   621  N N   . LEU A 1 305 ? 170.934 136.929 122.151 1.00 58.50  ? 305 LEU A N   1 
ATOM   622  C CA  . LEU A 1 305 ? 169.549 136.626 122.465 1.00 66.90  ? 305 LEU A CA  1 
ATOM   623  C C   . LEU A 1 305 ? 168.720 136.604 121.187 1.00 76.51  ? 305 LEU A C   1 
ATOM   624  O O   . LEU A 1 305 ? 169.052 137.256 120.194 1.00 74.82  ? 305 LEU A O   1 
ATOM   625  C CB  . LEU A 1 305 ? 168.961 137.648 123.445 1.00 66.03  ? 305 LEU A CB  1 
ATOM   626  C CG  . LEU A 1 305 ? 169.733 137.902 124.738 1.00 56.56  ? 305 LEU A CG  1 
ATOM   627  C CD1 . LEU A 1 305 ? 169.059 138.995 125.542 1.00 54.46  ? 305 LEU A CD1 1 
ATOM   628  C CD2 . LEU A 1 305 ? 169.846 136.628 125.548 1.00 56.73  ? 305 LEU A CD2 1 
ATOM   629  N N   . ASN A 1 306 ? 167.643 135.833 121.220 1.00 82.91  ? 306 ASN A N   1 
ATOM   630  C CA  . ASN A 1 306 ? 166.721 135.785 120.093 1.00 84.54  ? 306 ASN A CA  1 
ATOM   631  C C   . ASN A 1 306 ? 165.815 137.011 120.117 1.00 86.24  ? 306 ASN A C   1 
ATOM   632  O O   . ASN A 1 306 ? 165.223 137.316 121.156 1.00 83.48  ? 306 ASN A O   1 
ATOM   633  C CB  . ASN A 1 306 ? 165.891 134.510 120.134 1.00 80.67  ? 306 ASN A CB  1 
ATOM   634  C CG  . ASN A 1 306 ? 165.345 134.222 121.510 1.00 84.34  ? 306 ASN A CG  1 
ATOM   635  O OD1 . ASN A 1 306 ? 165.805 134.789 122.500 1.00 81.44  ? 306 ASN A OD1 1 
ATOM   636  N ND2 . ASN A 1 306 ? 164.363 133.333 121.584 1.00 88.31  ? 306 ASN A ND2 1 
ATOM   637  N N   . PRO A 1 307 ? 165.682 137.731 119.005 1.00 91.91  ? 307 PRO A N   1 
ATOM   638  C CA  . PRO A 1 307 ? 164.934 138.996 119.024 1.00 96.36  ? 307 PRO A CA  1 
ATOM   639  C C   . PRO A 1 307 ? 163.424 138.814 119.056 1.00 99.26  ? 307 PRO A C   1 
ATOM   640  O O   . PRO A 1 307 ? 162.680 139.766 118.804 1.00 97.07  ? 307 PRO A O   1 
ATOM   641  C CB  . PRO A 1 307 ? 165.379 139.686 117.726 1.00 94.96  ? 307 PRO A CB  1 
ATOM   642  C CG  . PRO A 1 307 ? 166.608 138.945 117.279 1.00 89.93  ? 307 PRO A CG  1 
ATOM   643  C CD  . PRO A 1 307 ? 166.405 137.542 117.739 1.00 86.47  ? 307 PRO A CD  1 
ATOM   644  N N   . ARG A 1 308 ? 162.954 137.602 119.354 1.00 101.70 ? 308 ARG A N   1 
ATOM   645  C CA  . ARG A 1 308 ? 161.527 137.322 119.380 1.00 103.78 ? 308 ARG A CA  1 
ATOM   646  C C   . ARG A 1 308 ? 161.008 136.817 120.719 1.00 94.18  ? 308 ARG A C   1 
ATOM   647  O O   . ARG A 1 308 ? 159.787 136.722 120.884 1.00 88.61  ? 308 ARG A O   1 
ATOM   648  C CB  . ARG A 1 308 ? 161.165 136.301 118.289 1.00 104.07 ? 308 ARG A CB  1 
ATOM   649  C CG  . ARG A 1 308 ? 161.354 136.817 116.872 1.00 106.80 ? 308 ARG A CG  1 
ATOM   650  C CD  . ARG A 1 308 ? 160.491 138.044 116.617 1.00 111.08 ? 308 ARG A CD  1 
ATOM   651  N NE  . ARG A 1 308 ? 160.683 138.584 115.276 1.00 117.67 ? 308 ARG A NE  1 
ATOM   652  C CZ  . ARG A 1 308 ? 161.566 139.524 114.967 1.00 117.19 ? 308 ARG A CZ  1 
ATOM   653  N NH1 . ARG A 1 308 ? 162.363 140.052 115.881 1.00 113.44 ? 308 ARG A NH1 1 
ATOM   654  N NH2 . ARG A 1 308 ? 161.650 139.946 113.708 1.00 116.51 ? 308 ARG A NH2 1 
ATOM   655  N N   . SER A 1 309 ? 161.880 136.488 121.676 1.00 86.50  ? 309 SER A N   1 
ATOM   656  C CA  . SER A 1 309 ? 161.410 135.984 122.961 1.00 83.26  ? 309 SER A CA  1 
ATOM   657  C C   . SER A 1 309 ? 162.215 136.548 124.125 1.00 84.90  ? 309 SER A C   1 
ATOM   658  O O   . SER A 1 309 ? 162.341 135.895 125.167 1.00 81.24  ? 309 SER A O   1 
ATOM   659  C CB  . SER A 1 309 ? 161.450 134.457 123.001 1.00 82.22  ? 309 SER A CB  1 
ATOM   660  O OG  . SER A 1 309 ? 162.782 133.988 123.077 1.00 83.75  ? 309 SER A OG  1 
ATOM   661  N N   . ASN A 1 310 ? 162.761 137.752 123.975 1.00 87.31  ? 310 ASN A N   1 
ATOM   662  C CA  . ASN A 1 310 ? 163.538 138.373 125.036 1.00 79.96  ? 310 ASN A CA  1 
ATOM   663  C C   . ASN A 1 310 ? 162.617 139.099 126.018 1.00 76.53  ? 310 ASN A C   1 
ATOM   664  O O   . ASN A 1 310 ? 161.404 139.200 125.820 1.00 76.46  ? 310 ASN A O   1 
ATOM   665  C CB  . ASN A 1 310 ? 164.579 139.319 124.444 1.00 73.17  ? 310 ASN A CB  1 
ATOM   666  C CG  . ASN A 1 310 ? 164.013 140.194 123.345 1.00 82.66  ? 310 ASN A CG  1 
ATOM   667  O OD1 . ASN A 1 310 ? 164.078 139.848 122.167 1.00 83.22  ? 310 ASN A OD1 1 
ATOM   668  N ND2 . ASN A 1 310 ? 163.453 141.334 123.726 1.00 81.93  ? 310 ASN A ND2 1 
ATOM   669  N N   . LEU A 1 311 ? 163.203 139.609 127.098 1.00 67.81  ? 311 LEU A N   1 
ATOM   670  C CA  . LEU A 1 311 ? 162.466 140.334 128.125 1.00 58.79  ? 311 LEU A CA  1 
ATOM   671  C C   . LEU A 1 311 ? 162.565 141.833 127.880 1.00 59.89  ? 311 LEU A C   1 
ATOM   672  O O   . LEU A 1 311 ? 163.650 142.352 127.597 1.00 62.72  ? 311 LEU A O   1 
ATOM   673  C CB  . LEU A 1 311 ? 162.995 140.014 129.524 1.00 56.76  ? 311 LEU A CB  1 
ATOM   674  C CG  . LEU A 1 311 ? 162.517 138.742 130.219 1.00 53.42  ? 311 LEU A CG  1 
ATOM   675  C CD1 . LEU A 1 311 ? 162.756 138.853 131.711 1.00 42.15  ? 311 LEU A CD1 1 
ATOM   676  C CD2 . LEU A 1 311 ? 161.052 138.482 129.927 1.00 52.81  ? 311 LEU A CD2 1 
ATOM   677  N N   . SER A 1 312 ? 161.435 142.519 127.989 1.00 52.73  ? 312 SER A N   1 
ATOM   678  C CA  . SER A 1 312 ? 161.419 143.971 127.986 1.00 46.73  ? 312 SER A CA  1 
ATOM   679  C C   . SER A 1 312 ? 161.672 144.493 129.396 1.00 42.90  ? 312 SER A C   1 
ATOM   680  O O   . SER A 1 312 ? 161.731 143.736 130.366 1.00 42.82  ? 312 SER A O   1 
ATOM   681  C CB  . SER A 1 312 ? 160.087 144.495 127.451 1.00 43.86  ? 312 SER A CB  1 
ATOM   682  O OG  . SER A 1 312 ? 159.017 144.132 128.305 1.00 40.74  ? 312 SER A OG  1 
ATOM   683  N N   . HIS A 1 313 ? 161.828 145.813 129.503 1.00 33.33  ? 313 HIS A N   1 
ATOM   684  C CA  . HIS A 1 313 ? 162.006 146.422 130.816 1.00 24.91  ? 313 HIS A CA  1 
ATOM   685  C C   . HIS A 1 313 ? 160.765 146.260 131.681 1.00 27.54  ? 313 HIS A C   1 
ATOM   686  O O   . HIS A 1 313 ? 160.862 146.285 132.913 1.00 25.39  ? 313 HIS A O   1 
ATOM   687  C CB  . HIS A 1 313 ? 162.363 147.898 130.663 1.00 26.36  ? 313 HIS A CB  1 
ATOM   688  C CG  . HIS A 1 313 ? 161.337 148.698 129.928 1.00 29.15  ? 313 HIS A CG  1 
ATOM   689  N ND1 . HIS A 1 313 ? 161.265 148.730 128.553 1.00 33.76  ? 313 HIS A ND1 1 
ATOM   690  C CD2 . HIS A 1 313 ? 160.348 149.506 130.376 1.00 29.19  ? 313 HIS A CD2 1 
ATOM   691  C CE1 . HIS A 1 313 ? 160.272 149.519 128.185 1.00 39.14  ? 313 HIS A CE1 1 
ATOM   692  N NE2 . HIS A 1 313 ? 159.698 150.001 129.272 1.00 38.37  ? 313 HIS A NE2 1 
ATOM   693  N N   . GLN A 1 314 ? 159.598 146.089 131.054 1.00 32.33  ? 314 GLN A N   1 
ATOM   694  C CA  . GLN A 1 314 ? 158.369 145.859 131.806 1.00 25.17  ? 314 GLN A CA  1 
ATOM   695  C C   . GLN A 1 314 ? 158.459 144.582 132.627 1.00 28.38  ? 314 GLN A C   1 
ATOM   696  O O   . GLN A 1 314 ? 158.066 144.559 133.797 1.00 26.37  ? 314 GLN A O   1 
ATOM   697  C CB  . GLN A 1 314 ? 157.180 145.784 130.851 1.00 26.54  ? 314 GLN A CB  1 
ATOM   698  C CG  . GLN A 1 314 ? 157.001 146.997 129.966 1.00 34.75  ? 314 GLN A CG  1 
ATOM   699  C CD  . GLN A 1 314 ? 156.223 148.099 130.643 1.00 37.11  ? 314 GLN A CD  1 
ATOM   700  O OE1 . GLN A 1 314 ? 155.988 148.059 131.848 1.00 37.13  ? 314 GLN A OE1 1 
ATOM   701  N NE2 . GLN A 1 314 ? 155.810 149.091 129.867 1.00 37.95  ? 314 GLN A NE2 1 
ATOM   702  N N   . HIS A 1 315 ? 158.982 143.509 132.034 1.00 31.15  ? 315 HIS A N   1 
ATOM   703  C CA  . HIS A 1 315 ? 159.072 142.241 132.746 1.00 24.61  ? 315 HIS A CA  1 
ATOM   704  C C   . HIS A 1 315 ? 160.090 142.309 133.877 1.00 24.02  ? 315 HIS A C   1 
ATOM   705  O O   . HIS A 1 315 ? 159.882 141.719 134.943 1.00 25.19  ? 315 HIS A O   1 
ATOM   706  C CB  . HIS A 1 315 ? 159.416 141.122 131.771 1.00 28.69  ? 315 HIS A CB  1 
ATOM   707  C CG  . HIS A 1 315 ? 158.416 140.955 130.671 1.00 35.21  ? 315 HIS A CG  1 
ATOM   708  N ND1 . HIS A 1 315 ? 158.553 141.563 129.442 1.00 37.04  ? 315 HIS A ND1 1 
ATOM   709  C CD2 . HIS A 1 315 ? 157.259 140.254 130.617 1.00 35.59  ? 315 HIS A CD2 1 
ATOM   710  C CE1 . HIS A 1 315 ? 157.526 141.240 128.676 1.00 38.84  ? 315 HIS A CE1 1 
ATOM   711  N NE2 . HIS A 1 315 ? 156.727 140.447 129.366 1.00 43.87  ? 315 HIS A NE2 1 
ATOM   712  N N   . LEU A 1 316 ? 161.200 143.016 133.662 1.00 22.72  ? 316 LEU A N   1 
ATOM   713  C CA  . LEU A 1 316 ? 162.169 143.207 134.735 1.00 18.91  ? 316 LEU A CA  1 
ATOM   714  C C   . LEU A 1 316 ? 161.568 144.003 135.886 1.00 21.48  ? 316 LEU A C   1 
ATOM   715  O O   . LEU A 1 316 ? 161.765 143.660 137.057 1.00 19.18  ? 316 LEU A O   1 
ATOM   716  C CB  . LEU A 1 316 ? 163.418 143.895 134.189 1.00 17.92  ? 316 LEU A CB  1 
ATOM   717  C CG  . LEU A 1 316 ? 164.333 142.993 133.361 1.00 21.11  ? 316 LEU A CG  1 
ATOM   718  C CD1 . LEU A 1 316 ? 165.421 143.797 132.687 1.00 21.33  ? 316 LEU A CD1 1 
ATOM   719  C CD2 . LEU A 1 316 ? 164.934 141.914 134.241 1.00 18.67  ? 316 LEU A CD2 1 
ATOM   720  N N   . PHE A 1 317 ? 160.818 145.062 135.571 1.00 25.01  ? 317 PHE A N   1 
ATOM   721  C CA  . PHE A 1 317 ? 160.115 145.809 136.610 1.00 21.50  ? 317 PHE A CA  1 
ATOM   722  C C   . PHE A 1 317 ? 159.109 144.928 137.335 1.00 25.70  ? 317 PHE A C   1 
ATOM   723  O O   . PHE A 1 317 ? 158.936 145.041 138.550 1.00 29.44  ? 317 PHE A O   1 
ATOM   724  C CB  . PHE A 1 317 ? 159.411 147.022 136.006 1.00 17.78  ? 317 PHE A CB  1 
ATOM   725  C CG  . PHE A 1 317 ? 160.341 148.106 135.561 1.00 22.25  ? 317 PHE A CG  1 
ATOM   726  C CD1 . PHE A 1 317 ? 161.560 148.288 136.178 1.00 23.96  ? 317 PHE A CD1 1 
ATOM   727  C CD2 . PHE A 1 317 ? 159.991 148.946 134.524 1.00 22.99  ? 317 PHE A CD2 1 
ATOM   728  C CE1 . PHE A 1 317 ? 162.410 149.284 135.768 1.00 20.49  ? 317 PHE A CE1 1 
ATOM   729  C CE2 . PHE A 1 317 ? 160.840 149.942 134.111 1.00 20.71  ? 317 PHE A CE2 1 
ATOM   730  C CZ  . PHE A 1 317 ? 162.049 150.111 134.733 1.00 19.53  ? 317 PHE A CZ  1 
ATOM   731  N N   . GLU A 1 318 ? 158.428 144.051 136.600 1.00 23.52  ? 318 GLU A N   1 
ATOM   732  C CA  . GLU A 1 318 ? 157.438 143.164 137.200 1.00 22.93  ? 318 GLU A CA  1 
ATOM   733  C C   . GLU A 1 318 ? 158.087 142.193 138.181 1.00 25.52  ? 318 GLU A C   1 
ATOM   734  O O   . GLU A 1 318 ? 157.602 142.005 139.304 1.00 24.49  ? 318 GLU A O   1 
ATOM   735  C CB  . GLU A 1 318 ? 156.710 142.415 136.087 1.00 20.13  ? 318 GLU A CB  1 
ATOM   736  C CG  . GLU A 1 318 ? 155.399 141.787 136.469 1.00 22.58  ? 318 GLU A CG  1 
ATOM   737  C CD  . GLU A 1 318 ? 154.681 141.236 135.261 1.00 34.43  ? 318 GLU A CD  1 
ATOM   738  O OE1 . GLU A 1 318 ? 155.094 141.565 134.132 1.00 36.64  ? 318 GLU A OE1 1 
ATOM   739  O OE2 . GLU A 1 318 ? 153.711 140.474 135.435 1.00 42.32  ? 318 GLU A OE2 1 
ATOM   740  N N   . ILE A 1 319 ? 159.194 141.569 137.769 1.00 22.60  ? 319 ILE A N   1 
ATOM   741  C CA  . ILE A 1 319 ? 159.914 140.647 138.647 1.00 21.26  ? 319 ILE A CA  1 
ATOM   742  C C   . ILE A 1 319 ? 160.447 141.380 139.870 1.00 22.78  ? 319 ILE A C   1 
ATOM   743  O O   . ILE A 1 319 ? 160.343 140.891 141.003 1.00 19.87  ? 319 ILE A O   1 
ATOM   744  C CB  . ILE A 1 319 ? 161.050 139.950 137.877 1.00 20.07  ? 319 ILE A CB  1 
ATOM   745  C CG1 . ILE A 1 319 ? 160.499 139.152 136.699 1.00 25.02  ? 319 ILE A CG1 1 
ATOM   746  C CG2 . ILE A 1 319 ? 161.844 139.049 138.802 1.00 20.60  ? 319 ILE A CG2 1 
ATOM   747  C CD1 . ILE A 1 319 ? 161.570 138.633 135.773 1.00 29.60  ? 319 ILE A CD1 1 
ATOM   748  N N   . ALA A 1 320 ? 161.036 142.561 139.660 1.00 20.60  ? 320 ALA A N   1 
ATOM   749  C CA  . ALA A 1 320 ? 161.571 143.329 140.776 1.00 18.61  ? 320 ALA A CA  1 
ATOM   750  C C   . ALA A 1 320 ? 160.470 143.729 141.745 1.00 25.05  ? 320 ALA A C   1 
ATOM   751  O O   . ALA A 1 320 ? 160.654 143.655 142.962 1.00 31.76  ? 320 ALA A O   1 
ATOM   752  C CB  . ALA A 1 320 ? 162.307 144.561 140.257 1.00 19.42  ? 320 ALA A CB  1 
ATOM   753  N N   . GLY A 1 321 ? 159.313 144.143 141.227 1.00 25.13  ? 321 GLY A N   1 
ATOM   754  C CA  . GLY A 1 321 ? 158.214 144.520 142.098 1.00 20.43  ? 321 GLY A CA  1 
ATOM   755  C C   . GLY A 1 321 ? 157.653 143.352 142.882 1.00 24.93  ? 321 GLY A C   1 
ATOM   756  O O   . GLY A 1 321 ? 157.344 143.486 144.066 1.00 27.82  ? 321 GLY A O   1 
ATOM   757  N N   . PHE A 1 322 ? 157.511 142.190 142.240 1.00 22.27  ? 322 PHE A N   1 
ATOM   758  C CA  . PHE A 1 322 ? 157.008 141.021 142.956 1.00 19.44  ? 322 PHE A CA  1 
ATOM   759  C C   . PHE A 1 322 ? 157.978 140.572 144.044 1.00 24.89  ? 322 PHE A C   1 
ATOM   760  O O   . PHE A 1 322 ? 157.566 140.281 145.177 1.00 29.57  ? 322 PHE A O   1 
ATOM   761  C CB  . PHE A 1 322 ? 156.733 139.886 141.974 1.00 21.00  ? 322 PHE A CB  1 
ATOM   762  C CG  . PHE A 1 322 ? 156.096 138.687 142.606 1.00 29.28  ? 322 PHE A CG  1 
ATOM   763  C CD1 . PHE A 1 322 ? 154.807 138.756 143.103 1.00 28.40  ? 322 PHE A CD1 1 
ATOM   764  C CD2 . PHE A 1 322 ? 156.782 137.490 142.703 1.00 33.65  ? 322 PHE A CD2 1 
ATOM   765  C CE1 . PHE A 1 322 ? 154.218 137.659 143.686 1.00 31.05  ? 322 PHE A CE1 1 
ATOM   766  C CE2 . PHE A 1 322 ? 156.197 136.389 143.286 1.00 37.46  ? 322 PHE A CE2 1 
ATOM   767  C CZ  . PHE A 1 322 ? 154.913 136.474 143.778 1.00 41.07  ? 322 PHE A CZ  1 
ATOM   768  N N   . LEU A 1 323 ? 159.274 140.518 143.725 1.00 24.57  ? 323 LEU A N   1 
ATOM   769  C CA  . LEU A 1 323 ? 160.256 140.152 144.737 1.00 21.57  ? 323 LEU A CA  1 
ATOM   770  C C   . LEU A 1 323 ? 160.339 141.196 145.843 1.00 23.09  ? 323 LEU A C   1 
ATOM   771  O O   . LEU A 1 323 ? 160.544 140.844 147.007 1.00 26.56  ? 323 LEU A O   1 
ATOM   772  C CB  . LEU A 1 323 ? 161.622 139.935 144.091 1.00 25.61  ? 323 LEU A CB  1 
ATOM   773  C CG  . LEU A 1 323 ? 161.699 138.739 143.139 1.00 30.37  ? 323 LEU A CG  1 
ATOM   774  C CD1 . LEU A 1 323 ? 163.086 138.611 142.540 1.00 33.57  ? 323 LEU A CD1 1 
ATOM   775  C CD2 . LEU A 1 323 ? 161.304 137.456 143.849 1.00 30.08  ? 323 LEU A CD2 1 
ATOM   776  N N   . GLY A 1 324 ? 160.166 142.476 145.510 1.00 21.04  ? 324 GLY A N   1 
ATOM   777  C CA  . GLY A 1 324 ? 160.123 143.499 146.539 1.00 20.78  ? 324 GLY A CA  1 
ATOM   778  C C   . GLY A 1 324 ? 158.906 143.380 147.432 1.00 26.73  ? 324 GLY A C   1 
ATOM   779  O O   . GLY A 1 324 ? 158.979 143.656 148.629 1.00 32.60  ? 324 GLY A O   1 
ATOM   780  N N   . ILE A 1 325 ? 157.768 142.980 146.864 1.00 24.48  ? 325 ILE A N   1 
ATOM   781  C CA  . ILE A 1 325 ? 156.582 142.730 147.677 1.00 25.37  ? 325 ILE A CA  1 
ATOM   782  C C   . ILE A 1 325 ? 156.841 141.592 148.650 1.00 27.40  ? 325 ILE A C   1 
ATOM   783  O O   . ILE A 1 325 ? 156.497 141.678 149.835 1.00 31.17  ? 325 ILE A O   1 
ATOM   784  C CB  . ILE A 1 325 ? 155.365 142.436 146.781 1.00 21.49  ? 325 ILE A CB  1 
ATOM   785  C CG1 . ILE A 1 325 ? 154.941 143.688 146.023 1.00 21.24  ? 325 ILE A CG1 1 
ATOM   786  C CG2 . ILE A 1 325 ? 154.203 141.923 147.610 1.00 24.92  ? 325 ILE A CG2 1 
ATOM   787  C CD1 . ILE A 1 325 ? 153.814 143.439 145.069 1.00 23.15  ? 325 ILE A CD1 1 
ATOM   788  N N   . LEU A 1 326 ? 157.452 140.508 148.167 1.00 22.96  ? 326 LEU A N   1 
ATOM   789  C CA  . LEU A 1 326 ? 157.782 139.398 149.059 1.00 26.89  ? 326 LEU A CA  1 
ATOM   790  C C   . LEU A 1 326 ? 158.765 139.830 150.143 1.00 28.33  ? 326 LEU A C   1 
ATOM   791  O O   . LEU A 1 326 ? 158.627 139.443 151.310 1.00 28.51  ? 326 LEU A O   1 
ATOM   792  C CB  . LEU A 1 326 ? 158.348 138.231 148.256 1.00 27.03  ? 326 LEU A CB  1 
ATOM   793  C CG  . LEU A 1 326 ? 157.389 137.607 147.245 1.00 34.91  ? 326 LEU A CG  1 
ATOM   794  C CD1 . LEU A 1 326 ? 158.102 136.547 146.431 1.00 37.47  ? 326 LEU A CD1 1 
ATOM   795  C CD2 . LEU A 1 326 ? 156.179 137.022 147.948 1.00 34.68  ? 326 LEU A CD2 1 
ATOM   796  N N   . TRP A 1 327 ? 159.761 140.636 149.772 1.00 25.43  ? 327 TRP A N   1 
ATOM   797  C CA  . TRP A 1 327 ? 160.742 141.132 150.732 1.00 24.42  ? 327 TRP A CA  1 
ATOM   798  C C   . TRP A 1 327 ? 160.090 142.006 151.797 1.00 26.74  ? 327 TRP A C   1 
ATOM   799  O O   . TRP A 1 327 ? 160.381 141.868 152.991 1.00 28.33  ? 327 TRP A O   1 
ATOM   800  C CB  . TRP A 1 327 ? 161.828 141.901 149.978 1.00 27.85  ? 327 TRP A CB  1 
ATOM   801  C CG  . TRP A 1 327 ? 162.921 142.475 150.817 1.00 28.08  ? 327 TRP A CG  1 
ATOM   802  C CD1 . TRP A 1 327 ? 164.041 141.835 151.250 1.00 23.33  ? 327 TRP A CD1 1 
ATOM   803  C CD2 . TRP A 1 327 ? 163.017 143.820 151.295 1.00 28.25  ? 327 TRP A CD2 1 
ATOM   804  N NE1 . TRP A 1 327 ? 164.820 142.692 151.984 1.00 24.29  ? 327 TRP A NE1 1 
ATOM   805  C CE2 . TRP A 1 327 ? 164.212 143.918 152.026 1.00 25.80  ? 327 TRP A CE2 1 
ATOM   806  C CE3 . TRP A 1 327 ? 162.200 144.948 151.185 1.00 24.54  ? 327 TRP A CE3 1 
ATOM   807  C CZ2 . TRP A 1 327 ? 164.612 145.097 152.645 1.00 24.89  ? 327 TRP A CZ2 1 
ATOM   808  C CZ3 . TRP A 1 327 ? 162.599 146.116 151.799 1.00 20.25  ? 327 TRP A CZ3 1 
ATOM   809  C CH2 . TRP A 1 327 ? 163.793 146.183 152.519 1.00 19.83  ? 327 TRP A CH2 1 
ATOM   810  N N   . CYS A 1 328 ? 159.199 142.909 151.381 1.00 28.44  ? 328 CYS A N   1 
ATOM   811  C CA  . CYS A 1 328 ? 158.502 143.772 152.329 1.00 28.12  ? 328 CYS A CA  1 
ATOM   812  C C   . CYS A 1 328 ? 157.590 142.969 153.243 1.00 30.72  ? 328 CYS A C   1 
ATOM   813  O O   . CYS A 1 328 ? 157.503 143.252 154.440 1.00 32.20  ? 328 CYS A O   1 
ATOM   814  C CB  . CYS A 1 328 ? 157.703 144.838 151.583 1.00 23.50  ? 328 CYS A CB  1 
ATOM   815  S SG  . CYS A 1 328 ? 158.706 146.115 150.809 1.00 44.80  ? 328 CYS A SG  1 
ATOM   816  N N   . LEU A 1 329 ? 156.892 141.971 152.696 1.00 29.38  ? 329 LEU A N   1 
ATOM   817  C CA  . LEU A 1 329 ? 156.036 141.132 153.527 1.00 27.87  ? 329 LEU A CA  1 
ATOM   818  C C   . LEU A 1 329 ? 156.850 140.359 154.555 1.00 33.06  ? 329 LEU A C   1 
ATOM   819  O O   . LEU A 1 329 ? 156.453 140.262 155.722 1.00 37.28  ? 329 LEU A O   1 
ATOM   820  C CB  . LEU A 1 329 ? 155.225 140.180 152.649 1.00 25.54  ? 329 LEU A CB  1 
ATOM   821  C CG  . LEU A 1 329 ? 154.103 140.827 151.837 1.00 25.15  ? 329 LEU A CG  1 
ATOM   822  C CD1 . LEU A 1 329 ? 153.500 139.829 150.870 1.00 23.38  ? 329 LEU A CD1 1 
ATOM   823  C CD2 . LEU A 1 329 ? 153.035 141.393 152.757 1.00 20.26  ? 329 LEU A CD2 1 
ATOM   824  N N   . SER A 1 330 ? 157.997 139.811 154.146 1.00 31.91  ? 330 SER A N   1 
ATOM   825  C CA  . SER A 1 330 ? 158.852 139.097 155.089 1.00 31.64  ? 330 SER A CA  1 
ATOM   826  C C   . SER A 1 330 ? 159.383 140.027 156.174 1.00 36.56  ? 330 SER A C   1 
ATOM   827  O O   . SER A 1 330 ? 159.404 139.668 157.358 1.00 42.50  ? 330 SER A O   1 
ATOM   828  C CB  . SER A 1 330 ? 160.003 138.428 154.341 1.00 35.89  ? 330 SER A CB  1 
ATOM   829  O OG  . SER A 1 330 ? 160.815 137.675 155.220 1.00 44.10  ? 330 SER A OG  1 
ATOM   830  N N   . LEU A 1 331 ? 159.810 141.232 155.792 1.00 35.23  ? 331 LEU A N   1 
ATOM   831  C CA  . LEU A 1 331 ? 160.343 142.167 156.778 1.00 33.93  ? 331 LEU A CA  1 
ATOM   832  C C   . LEU A 1 331 ? 159.257 142.642 157.739 1.00 44.56  ? 331 LEU A C   1 
ATOM   833  O O   . LEU A 1 331 ? 159.510 142.801 158.938 1.00 51.78  ? 331 LEU A O   1 
ATOM   834  C CB  . LEU A 1 331 ? 161.010 143.344 156.069 1.00 29.23  ? 331 LEU A CB  1 
ATOM   835  C CG  . LEU A 1 331 ? 161.947 144.213 156.904 1.00 32.93  ? 331 LEU A CG  1 
ATOM   836  C CD1 . LEU A 1 331 ? 162.770 143.360 157.839 1.00 40.52  ? 331 LEU A CD1 1 
ATOM   837  C CD2 . LEU A 1 331 ? 162.854 145.012 156.000 1.00 25.25  ? 331 LEU A CD2 1 
ATOM   838  N N   . LEU A 1 332 ? 158.042 142.876 157.234 1.00 41.29  ? 332 LEU A N   1 
ATOM   839  C CA  . LEU A 1 332 ? 156.929 143.246 158.103 1.00 40.44  ? 332 LEU A CA  1 
ATOM   840  C C   . LEU A 1 332 ? 156.560 142.109 159.047 1.00 49.25  ? 332 LEU A C   1 
ATOM   841  O O   . LEU A 1 332 ? 156.236 142.348 160.215 1.00 54.75  ? 332 LEU A O   1 
ATOM   842  C CB  . LEU A 1 332 ? 155.720 143.655 157.265 1.00 37.52  ? 332 LEU A CB  1 
ATOM   843  C CG  . LEU A 1 332 ? 155.700 145.079 156.713 1.00 39.80  ? 332 LEU A CG  1 
ATOM   844  C CD1 . LEU A 1 332 ? 154.525 145.268 155.772 1.00 30.15  ? 332 LEU A CD1 1 
ATOM   845  C CD2 . LEU A 1 332 ? 155.636 146.077 157.851 1.00 47.32  ? 332 LEU A CD2 1 
ATOM   846  N N   . ALA A 1 333 ? 156.588 140.868 158.557 1.00 44.96  ? 333 ALA A N   1 
ATOM   847  C CA  . ALA A 1 333 ? 156.331 139.729 159.428 1.00 49.25  ? 333 ALA A CA  1 
ATOM   848  C C   . ALA A 1 333 ? 157.384 139.632 160.521 1.00 57.08  ? 333 ALA A C   1 
ATOM   849  O O   . ALA A 1 333 ? 157.072 139.291 161.668 1.00 68.75  ? 333 ALA A O   1 
ATOM   850  C CB  . ALA A 1 333 ? 156.282 138.442 158.607 1.00 47.78  ? 333 ALA A CB  1 
ATOM   851  N N   . CYS A 1 334 ? 158.642 139.920 160.183 1.00 54.78  ? 334 CYS A N   1 
ATOM   852  C CA  . CYS A 1 334 ? 159.681 139.978 161.207 1.00 57.09  ? 334 CYS A CA  1 
ATOM   853  C C   . CYS A 1 334 ? 159.404 141.092 162.210 1.00 63.67  ? 334 CYS A C   1 
ATOM   854  O O   . CYS A 1 334 ? 159.627 140.923 163.414 1.00 69.14  ? 334 CYS A O   1 
ATOM   855  C CB  . CYS A 1 334 ? 161.052 140.165 160.559 1.00 51.47  ? 334 CYS A CB  1 
ATOM   856  S SG  . CYS A 1 334 ? 161.601 138.759 159.571 1.00 64.83  ? 334 CYS A SG  1 
ATOM   857  N N   . PHE A 1 335 ? 158.927 142.244 161.733 1.00 63.72  ? 335 PHE A N   1 
ATOM   858  C CA  . PHE A 1 335 ? 158.591 143.339 162.640 1.00 64.72  ? 335 PHE A CA  1 
ATOM   859  C C   . PHE A 1 335 ? 157.426 142.966 163.549 1.00 71.60  ? 335 PHE A C   1 
ATOM   860  O O   . PHE A 1 335 ? 157.466 143.214 164.759 1.00 74.24  ? 335 PHE A O   1 
ATOM   861  C CB  . PHE A 1 335 ? 158.257 144.604 161.847 1.00 60.13  ? 335 PHE A CB  1 
ATOM   862  C CG  . PHE A 1 335 ? 159.454 145.295 161.261 1.00 63.62  ? 335 PHE A CG  1 
ATOM   863  C CD1 . PHE A 1 335 ? 160.730 144.808 161.467 1.00 64.47  ? 335 PHE A CD1 1 
ATOM   864  C CD2 . PHE A 1 335 ? 159.300 146.444 160.507 1.00 62.60  ? 335 PHE A CD2 1 
ATOM   865  C CE1 . PHE A 1 335 ? 161.826 145.450 160.929 1.00 61.34  ? 335 PHE A CE1 1 
ATOM   866  C CE2 . PHE A 1 335 ? 160.394 147.088 159.969 1.00 53.88  ? 335 PHE A CE2 1 
ATOM   867  C CZ  . PHE A 1 335 ? 161.657 146.589 160.180 1.00 56.95  ? 335 PHE A CZ  1 
ATOM   868  N N   . PHE A 1 336 ? 156.377 142.369 162.983 1.00 72.66  ? 336 PHE A N   1 
ATOM   869  C CA  . PHE A 1 336 ? 155.167 142.038 163.734 1.00 77.10  ? 336 PHE A CA  1 
ATOM   870  C C   . PHE A 1 336 ? 155.238 140.574 164.162 1.00 86.26  ? 336 PHE A C   1 
ATOM   871  O O   . PHE A 1 336 ? 154.733 139.670 163.497 1.00 83.24  ? 336 PHE A O   1 
ATOM   872  C CB  . PHE A 1 336 ? 153.923 142.328 162.901 1.00 67.72  ? 336 PHE A CB  1 
ATOM   873  C CG  . PHE A 1 336 ? 153.690 143.789 162.650 1.00 65.01  ? 336 PHE A CG  1 
ATOM   874  C CD1 . PHE A 1 336 ? 153.016 144.564 163.576 1.00 69.24  ? 336 PHE A CD1 1 
ATOM   875  C CD2 . PHE A 1 336 ? 154.140 144.386 161.487 1.00 62.27  ? 336 PHE A CD2 1 
ATOM   876  C CE1 . PHE A 1 336 ? 152.799 145.907 163.349 1.00 68.63  ? 336 PHE A CE1 1 
ATOM   877  C CE2 . PHE A 1 336 ? 153.926 145.729 161.254 1.00 59.13  ? 336 PHE A CE2 1 
ATOM   878  C CZ  . PHE A 1 336 ? 153.254 146.490 162.186 1.00 63.55  ? 336 PHE A CZ  1 
ATOM   879  N N   . ALA A 1 337 ? 155.892 140.351 165.300 1.00 92.16  ? 337 ALA A N   1 
ATOM   880  C CA  . ALA A 1 337 ? 155.952 139.007 165.868 1.00 96.12  ? 337 ALA A CA  1 
ATOM   881  C C   . ALA A 1 337 ? 154.585 138.422 166.219 1.00 106.61 ? 337 ALA A C   1 
ATOM   882  O O   . ALA A 1 337 ? 154.358 137.241 165.904 1.00 104.26 ? 337 ALA A O   1 
ATOM   883  C CB  . ALA A 1 337 ? 156.873 139.009 167.096 1.00 90.34  ? 337 ALA A CB  1 
ATOM   884  N N   . PRO A 1 338 ? 153.640 139.157 166.854 1.00 114.69 ? 338 PRO A N   1 
ATOM   885  C CA  . PRO A 1 338 ? 152.380 138.520 167.275 1.00 114.20 ? 338 PRO A CA  1 
ATOM   886  C C   . PRO A 1 338 ? 151.492 138.028 166.139 1.00 110.58 ? 338 PRO A C   1 
ATOM   887  O O   . PRO A 1 338 ? 150.363 137.597 166.394 1.00 106.79 ? 338 PRO A O   1 
ATOM   888  C CB  . PRO A 1 338 ? 151.677 139.628 168.072 1.00 112.98 ? 338 PRO A CB  1 
ATOM   889  C CG  . PRO A 1 338 ? 152.767 140.527 168.513 1.00 109.20 ? 338 PRO A CG  1 
ATOM   890  C CD  . PRO A 1 338 ? 153.736 140.532 167.378 1.00 110.15 ? 338 PRO A CD  1 
ATOM   891  N N   . ILE A 1 339 ? 151.968 138.101 164.891 1.00 107.52 ? 339 ILE A N   1 
ATOM   892  C CA  . ILE A 1 339 ? 151.185 137.592 163.766 1.00 108.89 ? 339 ILE A CA  1 
ATOM   893  C C   . ILE A 1 339 ? 150.824 136.128 163.985 1.00 110.13 ? 339 ILE A C   1 
ATOM   894  O O   . ILE A 1 339 ? 149.679 135.715 163.767 1.00 107.21 ? 339 ILE A O   1 
ATOM   895  C CB  . ILE A 1 339 ? 151.948 137.794 162.443 1.00 101.32 ? 339 ILE A CB  1 
ATOM   896  C CG1 . ILE A 1 339 ? 151.963 139.271 162.050 1.00 95.54  ? 339 ILE A CG1 1 
ATOM   897  C CG2 . ILE A 1 339 ? 151.329 136.961 161.332 1.00 97.21  ? 339 ILE A CG2 1 
ATOM   898  C CD1 . ILE A 1 339 ? 152.684 139.542 160.752 1.00 81.12  ? 339 ILE A CD1 1 
ATOM   899  N N   . SER A 1 340 ? 151.788 135.325 164.426 1.00 110.07 ? 340 SER A N   1 
ATOM   900  C CA  . SER A 1 340 ? 151.549 133.921 164.723 1.00 107.24 ? 340 SER A CA  1 
ATOM   901  C C   . SER A 1 340 ? 152.581 133.458 165.743 1.00 106.75 ? 340 SER A C   1 
ATOM   902  O O   . SER A 1 340 ? 153.447 134.225 166.173 1.00 107.18 ? 340 SER A O   1 
ATOM   903  C CB  . SER A 1 340 ? 151.602 133.070 163.451 1.00 101.33 ? 340 SER A CB  1 
ATOM   904  O OG  . SER A 1 340 ? 150.646 133.503 162.501 1.00 101.33 ? 340 SER A OG  1 
ATOM   905  N N   . VAL A 1 341 ? 152.476 132.185 166.139 1.00 104.01 ? 341 VAL A N   1 
ATOM   906  C CA  . VAL A 1 341 ? 153.492 131.572 166.992 1.00 102.20 ? 341 VAL A CA  1 
ATOM   907  C C   . VAL A 1 341 ? 154.700 131.105 166.202 1.00 102.88 ? 341 VAL A C   1 
ATOM   908  O O   . VAL A 1 341 ? 155.645 130.565 166.793 1.00 101.44 ? 341 VAL A O   1 
ATOM   909  C CB  . VAL A 1 341 ? 152.918 130.376 167.777 1.00 103.77 ? 341 VAL A CB  1 
ATOM   910  C CG1 . VAL A 1 341 ? 151.675 130.796 168.546 1.00 101.09 ? 341 VAL A CG1 1 
ATOM   911  C CG2 . VAL A 1 341 ? 152.613 129.221 166.835 1.00 96.24  ? 341 VAL A CG2 1 
ATOM   912  N N   . ILE A 1 342 ? 154.695 131.288 164.888 1.00 103.86 ? 342 ILE A N   1 
ATOM   913  C CA  . ILE A 1 342 ? 155.820 130.871 164.044 1.00 96.83  ? 342 ILE A CA  1 
ATOM   914  C C   . ILE A 1 342 ? 157.041 131.714 164.388 1.00 93.18  ? 342 ILE A C   1 
ATOM   915  O O   . ILE A 1 342 ? 156.915 132.942 164.547 1.00 92.39  ? 342 ILE A O   1 
ATOM   916  C CB  . ILE A 1 342 ? 155.450 131.011 162.567 1.00 88.27  ? 342 ILE A CB  1 
ATOM   917  C CG1 . ILE A 1 342 ? 154.015 130.540 162.338 1.00 92.69  ? 342 ILE A CG1 1 
ATOM   918  C CG2 . ILE A 1 342 ? 156.392 130.203 161.703 1.00 84.29  ? 342 ILE A CG2 1 
ATOM   919  C CD1 . ILE A 1 342 ? 153.569 130.623 160.900 1.00 93.05  ? 342 ILE A CD1 1 
ATOM   920  N N   . PRO A 1 343 ? 158.225 131.119 164.524 1.00 89.18  ? 343 PRO A N   1 
ATOM   921  C CA  . PRO A 1 343 ? 159.417 131.909 164.844 1.00 85.42  ? 343 PRO A CA  1 
ATOM   922  C C   . PRO A 1 343 ? 159.733 132.915 163.748 1.00 85.67  ? 343 PRO A C   1 
ATOM   923  O O   . PRO A 1 343 ? 159.436 132.711 162.570 1.00 90.17  ? 343 PRO A O   1 
ATOM   924  C CB  . PRO A 1 343 ? 160.521 130.854 164.965 1.00 90.83  ? 343 PRO A CB  1 
ATOM   925  C CG  . PRO A 1 343 ? 159.803 129.584 165.258 1.00 91.58  ? 343 PRO A CG  1 
ATOM   926  C CD  . PRO A 1 343 ? 158.506 129.674 164.519 1.00 87.96  ? 343 PRO A CD  1 
ATOM   927  N N   . THR A 1 344 ? 160.340 134.029 164.160 1.00 84.24  ? 344 THR A N   1 
ATOM   928  C CA  . THR A 1 344 ? 160.657 135.088 163.209 1.00 84.02  ? 344 THR A CA  1 
ATOM   929  C C   . THR A 1 344 ? 161.732 134.661 162.220 1.00 84.46  ? 344 THR A C   1 
ATOM   930  O O   . THR A 1 344 ? 161.671 135.038 161.044 1.00 82.88  ? 344 THR A O   1 
ATOM   931  C CB  . THR A 1 344 ? 161.099 136.350 163.949 1.00 86.47  ? 344 THR A CB  1 
ATOM   932  O OG1 . THR A 1 344 ? 162.301 136.080 164.679 1.00 97.41  ? 344 THR A OG1 1 
ATOM   933  C CG2 . THR A 1 344 ? 160.018 136.804 164.917 1.00 83.19  ? 344 THR A CG2 1 
ATOM   934  N N   . TYR A 1 345 ? 162.710 133.866 162.664 1.00 84.57  ? 345 TYR A N   1 
ATOM   935  C CA  . TYR A 1 345 ? 163.838 133.526 161.803 1.00 83.37  ? 345 TYR A CA  1 
ATOM   936  C C   . TYR A 1 345 ? 163.431 132.682 160.602 1.00 79.68  ? 345 TYR A C   1 
ATOM   937  O O   . TYR A 1 345 ? 164.227 132.539 159.668 1.00 78.61  ? 345 TYR A O   1 
ATOM   938  C CB  . TYR A 1 345 ? 164.926 132.806 162.603 1.00 90.05  ? 345 TYR A CB  1 
ATOM   939  C CG  . TYR A 1 345 ? 164.469 131.585 163.372 1.00 95.74  ? 345 TYR A CG  1 
ATOM   940  C CD1 . TYR A 1 345 ? 164.215 130.383 162.725 1.00 91.74  ? 345 TYR A CD1 1 
ATOM   941  C CD2 . TYR A 1 345 ? 164.321 131.628 164.752 1.00 101.41 ? 345 TYR A CD2 1 
ATOM   942  C CE1 . TYR A 1 345 ? 163.808 129.267 163.425 1.00 96.18  ? 345 TYR A CE1 1 
ATOM   943  C CE2 . TYR A 1 345 ? 163.918 130.515 165.462 1.00 105.26 ? 345 TYR A CE2 1 
ATOM   944  C CZ  . TYR A 1 345 ? 163.662 129.338 164.793 1.00 106.50 ? 345 TYR A CZ  1 
ATOM   945  O OH  . TYR A 1 345 ? 163.257 128.226 165.494 1.00 109.88 ? 345 TYR A OH  1 
ATOM   946  N N   . VAL A 1 346 ? 162.223 132.116 160.602 1.00 77.36  ? 346 VAL A N   1 
ATOM   947  C CA  . VAL A 1 346 ? 161.766 131.372 159.435 1.00 75.77  ? 346 VAL A CA  1 
ATOM   948  C C   . VAL A 1 346 ? 161.295 132.298 158.322 1.00 69.67  ? 346 VAL A C   1 
ATOM   949  O O   . VAL A 1 346 ? 161.222 131.871 157.163 1.00 68.58  ? 346 VAL A O   1 
ATOM   950  C CB  . VAL A 1 346 ? 160.645 130.388 159.813 1.00 77.26  ? 346 VAL A CB  1 
ATOM   951  C CG1 . VAL A 1 346 ? 159.298 131.084 159.811 1.00 73.15  ? 346 VAL A CG1 1 
ATOM   952  C CG2 . VAL A 1 346 ? 160.638 129.197 158.865 1.00 68.83  ? 346 VAL A CG2 1 
ATOM   953  N N   . TYR A 1 347 ? 160.963 133.549 158.640 1.00 68.66  ? 347 TYR A N   1 
ATOM   954  C CA  . TYR A 1 347 ? 160.520 134.476 157.602 1.00 63.15  ? 347 TYR A CA  1 
ATOM   955  C C   . TYR A 1 347 ? 161.603 134.807 156.581 1.00 60.87  ? 347 TYR A C   1 
ATOM   956  O O   . TYR A 1 347 ? 161.285 134.819 155.379 1.00 56.84  ? 347 TYR A O   1 
ATOM   957  C CB  . TYR A 1 347 ? 159.950 135.745 158.246 1.00 54.90  ? 347 TYR A CB  1 
ATOM   958  C CG  . TYR A 1 347 ? 158.640 135.503 158.953 1.00 62.06  ? 347 TYR A CG  1 
ATOM   959  C CD1 . TYR A 1 347 ? 157.526 135.064 158.251 1.00 60.56  ? 347 TYR A CD1 1 
ATOM   960  C CD2 . TYR A 1 347 ? 158.515 135.706 160.319 1.00 64.57  ? 347 TYR A CD2 1 
ATOM   961  C CE1 . TYR A 1 347 ? 156.326 134.834 158.889 1.00 58.33  ? 347 TYR A CE1 1 
ATOM   962  C CE2 . TYR A 1 347 ? 157.318 135.481 160.965 1.00 67.81  ? 347 TYR A CE2 1 
ATOM   963  C CZ  . TYR A 1 347 ? 156.228 135.045 160.245 1.00 67.92  ? 347 TYR A CZ  1 
ATOM   964  O OH  . TYR A 1 347 ? 155.032 134.820 160.884 1.00 86.62  ? 347 TYR A OH  1 
ATOM   965  N N   . PRO A 1 348 ? 162.854 135.107 156.956 1.00 57.33  ? 348 PRO A N   1 
ATOM   966  C CA  . PRO A 1 348 ? 163.884 135.260 155.915 1.00 55.47  ? 348 PRO A CA  1 
ATOM   967  C C   . PRO A 1 348 ? 164.065 134.012 155.073 1.00 61.00  ? 348 PRO A C   1 
ATOM   968  O O   . PRO A 1 348 ? 164.173 134.107 153.843 1.00 61.43  ? 348 PRO A O   1 
ATOM   969  C CB  . PRO A 1 348 ? 165.146 135.593 156.719 1.00 49.89  ? 348 PRO A CB  1 
ATOM   970  C CG  . PRO A 1 348 ? 164.646 136.177 157.977 1.00 50.24  ? 348 PRO A CG  1 
ATOM   971  C CD  . PRO A 1 348 ? 163.387 135.438 158.290 1.00 55.13  ? 348 PRO A CD  1 
ATOM   972  N N   . LEU A 1 349 ? 164.063 132.834 155.703 1.00 60.18  ? 349 LEU A N   1 
ATOM   973  C CA  . LEU A 1 349 ? 164.242 131.592 154.958 1.00 59.44  ? 349 LEU A CA  1 
ATOM   974  C C   . LEU A 1 349 ? 163.106 131.377 153.970 1.00 59.07  ? 349 LEU A C   1 
ATOM   975  O O   . LEU A 1 349 ? 163.330 130.915 152.845 1.00 61.89  ? 349 LEU A O   1 
ATOM   976  C CB  . LEU A 1 349 ? 164.344 130.411 155.921 1.00 58.25  ? 349 LEU A CB  1 
ATOM   977  C CG  . LEU A 1 349 ? 165.494 130.444 156.926 1.00 68.63  ? 349 LEU A CG  1 
ATOM   978  C CD1 . LEU A 1 349 ? 165.467 129.205 157.801 1.00 73.44  ? 349 LEU A CD1 1 
ATOM   979  C CD2 . LEU A 1 349 ? 166.826 130.568 156.211 1.00 68.11  ? 349 LEU A CD2 1 
ATOM   980  N N   . ALA A 1 350 ? 161.877 131.700 154.374 1.00 55.26  ? 350 ALA A N   1 
ATOM   981  C CA  . ALA A 1 350 ? 160.751 131.607 153.454 1.00 55.56  ? 350 ALA A CA  1 
ATOM   982  C C   . ALA A 1 350 ? 160.914 132.560 152.279 1.00 62.89  ? 350 ALA A C   1 
ATOM   983  O O   . ALA A 1 350 ? 160.407 132.286 151.186 1.00 60.96  ? 350 ALA A O   1 
ATOM   984  C CB  . ALA A 1 350 ? 159.443 131.890 154.189 1.00 51.58  ? 350 ALA A CB  1 
ATOM   985  N N   . LEU A 1 351 ? 161.615 133.676 152.478 1.00 61.68  ? 351 LEU A N   1 
ATOM   986  C CA  . LEU A 1 351 ? 161.825 134.619 151.385 1.00 50.36  ? 351 LEU A CA  1 
ATOM   987  C C   . LEU A 1 351 ? 162.903 134.122 150.432 1.00 54.68  ? 351 LEU A C   1 
ATOM   988  O O   . LEU A 1 351 ? 162.632 133.845 149.259 1.00 56.89  ? 351 LEU A O   1 
ATOM   989  C CB  . LEU A 1 351 ? 162.196 135.995 151.941 1.00 43.80  ? 351 LEU A CB  1 
ATOM   990  C CG  . LEU A 1 351 ? 162.681 137.011 150.907 1.00 49.18  ? 351 LEU A CG  1 
ATOM   991  C CD1 . LEU A 1 351 ? 161.594 137.308 149.889 1.00 48.00  ? 351 LEU A CD1 1 
ATOM   992  C CD2 . LEU A 1 351 ? 163.155 138.281 151.588 1.00 43.20  ? 351 LEU A CD2 1 
ATOM   993  N N   . TYR A 1 352 ? 164.131 133.977 150.935 1.00 52.27  ? 352 TYR A N   1 
ATOM   994  C CA  . TYR A 1 352 ? 165.251 133.619 150.071 1.00 51.83  ? 352 TYR A CA  1 
ATOM   995  C C   . TYR A 1 352 ? 165.043 132.254 149.436 1.00 56.95  ? 352 TYR A C   1 
ATOM   996  O O   . TYR A 1 352 ? 165.300 132.074 148.239 1.00 61.43  ? 352 TYR A O   1 
ATOM   997  C CB  . TYR A 1 352 ? 166.552 133.666 150.866 1.00 41.56  ? 352 TYR A CB  1 
ATOM   998  C CG  . TYR A 1 352 ? 166.920 135.067 151.271 1.00 50.54  ? 352 TYR A CG  1 
ATOM   999  C CD1 . TYR A 1 352 ? 166.919 136.094 150.340 1.00 51.30  ? 352 TYR A CD1 1 
ATOM   1000 C CD2 . TYR A 1 352 ? 167.238 135.373 152.584 1.00 54.06  ? 352 TYR A CD2 1 
ATOM   1001 C CE1 . TYR A 1 352 ? 167.241 137.380 150.699 1.00 49.80  ? 352 TYR A CE1 1 
ATOM   1002 C CE2 . TYR A 1 352 ? 167.563 136.661 152.955 1.00 51.38  ? 352 TYR A CE2 1 
ATOM   1003 C CZ  . TYR A 1 352 ? 167.563 137.659 152.007 1.00 49.91  ? 352 TYR A CZ  1 
ATOM   1004 O OH  . TYR A 1 352 ? 167.885 138.944 152.362 1.00 48.10  ? 352 TYR A OH  1 
ATOM   1005 N N   . GLY A 1 353 ? 164.548 131.288 150.212 1.00 50.64  ? 353 GLY A N   1 
ATOM   1006 C CA  . GLY A 1 353 ? 164.195 130.006 149.631 1.00 52.54  ? 353 GLY A CA  1 
ATOM   1007 C C   . GLY A 1 353 ? 163.218 130.154 148.483 1.00 61.77  ? 353 GLY A C   1 
ATOM   1008 O O   . GLY A 1 353 ? 163.392 129.544 147.424 1.00 58.63  ? 353 GLY A O   1 
ATOM   1009 N N   . PHE A 1 354 ? 162.203 131.004 148.659 1.00 60.77  ? 354 PHE A N   1 
ATOM   1010 C CA  . PHE A 1 354 ? 161.287 131.289 147.561 1.00 59.33  ? 354 PHE A CA  1 
ATOM   1011 C C   . PHE A 1 354 ? 162.042 131.861 146.371 1.00 59.65  ? 354 PHE A C   1 
ATOM   1012 O O   . PHE A 1 354 ? 161.830 131.442 145.227 1.00 58.38  ? 354 PHE A O   1 
ATOM   1013 C CB  . PHE A 1 354 ? 160.193 132.253 148.021 1.00 57.01  ? 354 PHE A CB  1 
ATOM   1014 C CG  . PHE A 1 354 ? 159.036 132.356 147.068 1.00 62.24  ? 354 PHE A CG  1 
ATOM   1015 C CD1 . PHE A 1 354 ? 159.115 133.155 145.940 1.00 60.34  ? 354 PHE A CD1 1 
ATOM   1016 C CD2 . PHE A 1 354 ? 157.866 131.655 147.304 1.00 63.29  ? 354 PHE A CD2 1 
ATOM   1017 C CE1 . PHE A 1 354 ? 158.055 133.248 145.062 1.00 61.13  ? 354 PHE A CE1 1 
ATOM   1018 C CE2 . PHE A 1 354 ? 156.802 131.747 146.432 1.00 70.36  ? 354 PHE A CE2 1 
ATOM   1019 C CZ  . PHE A 1 354 ? 156.897 132.545 145.309 1.00 69.54  ? 354 PHE A CZ  1 
ATOM   1020 N N   . MET A 1 355 ? 162.953 132.806 146.627 1.00 57.10  ? 355 MET A N   1 
ATOM   1021 C CA  . MET A 1 355 ? 163.755 133.364 145.545 1.00 54.33  ? 355 MET A CA  1 
ATOM   1022 C C   . MET A 1 355 ? 164.556 132.282 144.840 1.00 60.78  ? 355 MET A C   1 
ATOM   1023 O O   . MET A 1 355 ? 164.836 132.399 143.642 1.00 60.58  ? 355 MET A O   1 
ATOM   1024 C CB  . MET A 1 355 ? 164.688 134.449 146.077 1.00 53.93  ? 355 MET A CB  1 
ATOM   1025 C CG  . MET A 1 355 ? 163.999 135.755 146.416 1.00 58.37  ? 355 MET A CG  1 
ATOM   1026 S SD  . MET A 1 355 ? 165.176 137.075 146.756 1.00 80.88  ? 355 MET A SD  1 
ATOM   1027 C CE  . MET A 1 355 ? 164.070 138.454 147.023 1.00 52.55  ? 355 MET A CE  1 
ATOM   1028 N N   . VAL A 1 356 ? 164.932 131.226 145.560 1.00 58.67  ? 356 VAL A N   1 
ATOM   1029 C CA  . VAL A 1 356 ? 165.557 130.084 144.907 1.00 57.31  ? 356 VAL A CA  1 
ATOM   1030 C C   . VAL A 1 356 ? 164.516 129.279 144.143 1.00 60.29  ? 356 VAL A C   1 
ATOM   1031 O O   . VAL A 1 356 ? 164.708 128.948 142.967 1.00 62.55  ? 356 VAL A O   1 
ATOM   1032 C CB  . VAL A 1 356 ? 166.301 129.219 145.938 1.00 57.05  ? 356 VAL A CB  1 
ATOM   1033 C CG1 . VAL A 1 356 ? 166.943 128.025 145.259 1.00 55.67  ? 356 VAL A CG1 1 
ATOM   1034 C CG2 . VAL A 1 356 ? 167.348 130.048 146.659 1.00 55.94  ? 356 VAL A CG2 1 
ATOM   1035 N N   . PHE A 1 357 ? 163.381 128.990 144.786 1.00 58.99  ? 357 PHE A N   1 
ATOM   1036 C CA  . PHE A 1 357 ? 162.364 128.158 144.151 1.00 60.35  ? 357 PHE A CA  1 
ATOM   1037 C C   . PHE A 1 357 ? 161.810 128.828 142.902 1.00 56.98  ? 357 PHE A C   1 
ATOM   1038 O O   . PHE A 1 357 ? 161.522 128.157 141.906 1.00 54.79  ? 357 PHE A O   1 
ATOM   1039 C CB  . PHE A 1 357 ? 161.241 127.847 145.139 1.00 62.95  ? 357 PHE A CB  1 
ATOM   1040 C CG  . PHE A 1 357 ? 161.676 127.011 146.309 1.00 74.93  ? 357 PHE A CG  1 
ATOM   1041 C CD1 . PHE A 1 357 ? 162.805 126.212 146.227 1.00 76.18  ? 357 PHE A CD1 1 
ATOM   1042 C CD2 . PHE A 1 357 ? 160.956 127.023 147.492 1.00 75.90  ? 357 PHE A CD2 1 
ATOM   1043 C CE1 . PHE A 1 357 ? 163.208 125.444 147.302 1.00 77.71  ? 357 PHE A CE1 1 
ATOM   1044 C CE2 . PHE A 1 357 ? 161.354 126.256 148.571 1.00 76.73  ? 357 PHE A CE2 1 
ATOM   1045 C CZ  . PHE A 1 357 ? 162.482 125.466 148.475 1.00 76.80  ? 357 PHE A CZ  1 
ATOM   1046 N N   . PHE A 1 358 ? 161.655 130.152 142.938 1.00 56.37  ? 358 PHE A N   1 
ATOM   1047 C CA  . PHE A 1 358 ? 161.254 130.881 141.741 1.00 50.71  ? 358 PHE A CA  1 
ATOM   1048 C C   . PHE A 1 358 ? 162.294 130.737 140.638 1.00 51.84  ? 358 PHE A C   1 
ATOM   1049 O O   . PHE A 1 358 ? 161.945 130.575 139.464 1.00 49.30  ? 358 PHE A O   1 
ATOM   1050 C CB  . PHE A 1 358 ? 161.024 132.355 142.079 1.00 48.17  ? 358 PHE A CB  1 
ATOM   1051 C CG  . PHE A 1 358 ? 160.730 133.218 140.883 1.00 50.48  ? 358 PHE A CG  1 
ATOM   1052 C CD1 . PHE A 1 358 ? 159.453 133.286 140.357 1.00 54.65  ? 358 PHE A CD1 1 
ATOM   1053 C CD2 . PHE A 1 358 ? 161.730 133.971 140.292 1.00 51.33  ? 358 PHE A CD2 1 
ATOM   1054 C CE1 . PHE A 1 358 ? 159.181 134.079 139.259 1.00 54.17  ? 358 PHE A CE1 1 
ATOM   1055 C CE2 . PHE A 1 358 ? 161.462 134.766 139.192 1.00 45.20  ? 358 PHE A CE2 1 
ATOM   1056 C CZ  . PHE A 1 358 ? 160.188 134.820 138.678 1.00 43.96  ? 358 PHE A CZ  1 
ATOM   1057 N N   . LEU A 1 359 ? 163.579 130.791 140.996 1.00 53.73  ? 359 LEU A N   1 
ATOM   1058 C CA  . LEU A 1 359 ? 164.630 130.782 139.983 1.00 55.11  ? 359 LEU A CA  1 
ATOM   1059 C C   . LEU A 1 359 ? 164.787 129.403 139.352 1.00 55.39  ? 359 LEU A C   1 
ATOM   1060 O O   . LEU A 1 359 ? 164.880 129.279 138.125 1.00 52.16  ? 359 LEU A O   1 
ATOM   1061 C CB  . LEU A 1 359 ? 165.950 131.247 140.594 1.00 51.15  ? 359 LEU A CB  1 
ATOM   1062 C CG  . LEU A 1 359 ? 167.142 131.299 139.638 1.00 50.03  ? 359 LEU A CG  1 
ATOM   1063 C CD1 . LEU A 1 359 ? 166.895 132.296 138.520 1.00 39.93  ? 359 LEU A CD1 1 
ATOM   1064 C CD2 . LEU A 1 359 ? 168.416 131.634 140.391 1.00 41.26  ? 359 LEU A CD2 1 
ATOM   1065 N N   . ILE A 1 360 ? 164.808 128.356 140.170 1.00 53.17  ? 360 ILE A N   1 
ATOM   1066 C CA  . ILE A 1 360 ? 165.066 127.006 139.690 1.00 52.20  ? 360 ILE A CA  1 
ATOM   1067 C C   . ILE A 1 360 ? 163.766 126.239 139.449 1.00 58.54  ? 360 ILE A C   1 
ATOM   1068 O O   . ILE A 1 360 ? 163.777 125.012 139.388 1.00 62.01  ? 360 ILE A O   1 
ATOM   1069 C CB  . ILE A 1 360 ? 165.994 126.235 140.640 1.00 56.35  ? 360 ILE A CB  1 
ATOM   1070 C CG1 . ILE A 1 360 ? 165.307 126.006 141.987 1.00 60.32  ? 360 ILE A CG1 1 
ATOM   1071 C CG2 . ILE A 1 360 ? 167.307 126.977 140.819 1.00 52.96  ? 360 ILE A CG2 1 
ATOM   1072 C CD1 . ILE A 1 360 ? 166.119 125.190 142.959 1.00 58.27  ? 360 ILE A CD1 1 
ATOM   1073 N N   . ASN A 1 361 ? 162.651 126.941 139.312 1.00 59.92  ? 361 ASN A N   1 
ATOM   1074 C CA  . ASN A 1 361 ? 161.377 126.291 139.051 1.00 58.98  ? 361 ASN A CA  1 
ATOM   1075 C C   . ASN A 1 361 ? 161.405 125.641 137.673 1.00 66.62  ? 361 ASN A C   1 
ATOM   1076 O O   . ASN A 1 361 ? 161.576 126.347 136.668 1.00 62.63  ? 361 ASN A O   1 
ATOM   1077 C CB  . ASN A 1 361 ? 160.244 127.310 139.137 1.00 56.46  ? 361 ASN A CB  1 
ATOM   1078 C CG  . ASN A 1 361 ? 158.888 126.697 138.878 1.00 69.16  ? 361 ASN A CG  1 
ATOM   1079 O OD1 . ASN A 1 361 ? 158.320 126.853 137.798 1.00 70.51  ? 361 ASN A OD1 1 
ATOM   1080 N ND2 . ASN A 1 361 ? 158.357 125.995 139.872 1.00 71.85  ? 361 ASN A ND2 1 
ATOM   1081 N N   . PRO A 1 362 ? 161.244 124.323 137.575 1.00 69.23  ? 362 PRO A N   1 
ATOM   1082 C CA  . PRO A 1 362 ? 161.301 123.643 136.274 1.00 62.97  ? 362 PRO A CA  1 
ATOM   1083 C C   . PRO A 1 362 ? 159.957 123.452 135.587 1.00 65.31  ? 362 PRO A C   1 
ATOM   1084 O O   . PRO A 1 362 ? 159.901 122.730 134.587 1.00 68.20  ? 362 PRO A O   1 
ATOM   1085 C CB  . PRO A 1 362 ? 161.897 122.284 136.656 1.00 59.26  ? 362 PRO A CB  1 
ATOM   1086 C CG  . PRO A 1 362 ? 161.317 122.020 138.008 1.00 57.51  ? 362 PRO A CG  1 
ATOM   1087 C CD  . PRO A 1 362 ? 161.159 123.361 138.689 1.00 59.79  ? 362 PRO A CD  1 
ATOM   1088 N N   . THR A 1 363 ? 158.890 124.074 136.079 1.00 63.24  ? 363 THR A N   1 
ATOM   1089 C CA  . THR A 1 363 ? 157.542 123.806 135.598 1.00 64.64  ? 363 THR A CA  1 
ATOM   1090 C C   . THR A 1 363 ? 157.186 124.578 134.337 1.00 62.48  ? 363 THR A C   1 
ATOM   1091 O O   . THR A 1 363 ? 156.056 124.450 133.856 1.00 67.52  ? 363 THR A O   1 
ATOM   1092 C CB  . THR A 1 363 ? 156.518 124.120 136.691 1.00 63.31  ? 363 THR A CB  1 
ATOM   1093 O OG1 . THR A 1 363 ? 156.582 125.512 137.021 1.00 72.93  ? 363 THR A OG1 1 
ATOM   1094 C CG2 . THR A 1 363 ? 156.804 123.297 137.936 1.00 65.31  ? 363 THR A CG2 1 
ATOM   1095 N N   . LYS A 1 364 ? 158.110 125.376 133.798 1.00 56.91  ? 364 LYS A N   1 
ATOM   1096 C CA  . LYS A 1 364 ? 157.886 126.115 132.555 1.00 62.63  ? 364 LYS A CA  1 
ATOM   1097 C C   . LYS A 1 364 ? 156.683 127.052 132.686 1.00 70.28  ? 364 LYS A C   1 
ATOM   1098 O O   . LYS A 1 364 ? 155.790 127.085 131.838 1.00 69.13  ? 364 LYS A O   1 
ATOM   1099 C CB  . LYS A 1 364 ? 157.724 125.149 131.376 1.00 58.84  ? 364 LYS A CB  1 
ATOM   1100 C CG  . LYS A 1 364 ? 157.788 125.785 129.999 1.00 63.91  ? 364 LYS A CG  1 
ATOM   1101 C CD  . LYS A 1 364 ? 157.921 124.740 128.907 1.00 63.43  ? 364 LYS A CD  1 
ATOM   1102 C CE  . LYS A 1 364 ? 159.240 123.997 129.019 1.00 64.91  ? 364 LYS A CE  1 
ATOM   1103 N NZ  . LYS A 1 364 ? 159.431 123.037 127.900 1.00 65.77  ? 364 LYS A NZ  1 
ATOM   1104 N N   . THR A 1 365 ? 156.661 127.820 133.776 1.00 69.78  ? 365 THR A N   1 
ATOM   1105 C CA  . THR A 1 365 ? 155.509 128.655 134.097 1.00 69.96  ? 365 THR A CA  1 
ATOM   1106 C C   . THR A 1 365 ? 155.830 130.144 134.068 1.00 71.57  ? 365 THR A C   1 
ATOM   1107 O O   . THR A 1 365 ? 155.182 130.890 133.327 1.00 75.29  ? 365 THR A O   1 
ATOM   1108 C CB  . THR A 1 365 ? 154.946 128.256 135.467 1.00 70.44  ? 365 THR A CB  1 
ATOM   1109 O OG1 . THR A 1 365 ? 154.742 126.839 135.505 1.00 73.70  ? 365 THR A OG1 1 
ATOM   1110 C CG2 . THR A 1 365 ? 153.621 128.951 135.719 1.00 70.12  ? 365 THR A CG2 1 
ATOM   1111 N N   . PHE A 1 366 ? 156.809 130.606 134.844 1.00 66.53  ? 366 PHE A N   1 
ATOM   1112 C CA  . PHE A 1 366 ? 157.071 132.035 135.022 1.00 56.35  ? 366 PHE A CA  1 
ATOM   1113 C C   . PHE A 1 366 ? 158.431 132.372 134.425 1.00 55.94  ? 366 PHE A C   1 
ATOM   1114 O O   . PHE A 1 366 ? 159.466 132.070 135.025 1.00 59.87  ? 366 PHE A O   1 
ATOM   1115 C CB  . PHE A 1 366 ? 157.020 132.422 136.497 1.00 55.23  ? 366 PHE A CB  1 
ATOM   1116 C CG  . PHE A 1 366 ? 155.695 132.165 137.147 1.00 63.60  ? 366 PHE A CG  1 
ATOM   1117 C CD1 . PHE A 1 366 ? 154.611 132.984 136.886 1.00 62.82  ? 366 PHE A CD1 1 
ATOM   1118 C CD2 . PHE A 1 366 ? 155.535 131.113 138.029 1.00 63.69  ? 366 PHE A CD2 1 
ATOM   1119 C CE1 . PHE A 1 366 ? 153.389 132.753 137.485 1.00 60.62  ? 366 PHE A CE1 1 
ATOM   1120 C CE2 . PHE A 1 366 ? 154.316 130.877 138.632 1.00 68.72  ? 366 PHE A CE2 1 
ATOM   1121 C CZ  . PHE A 1 366 ? 153.242 131.699 138.359 1.00 64.30  ? 366 PHE A CZ  1 
ATOM   1122 N N   . TYR A 1 367 ? 158.424 133.014 133.258 1.00 56.86  ? 367 TYR A N   1 
ATOM   1123 C CA  . TYR A 1 367 ? 159.648 133.460 132.593 1.00 52.89  ? 367 TYR A CA  1 
ATOM   1124 C C   . TYR A 1 367 ? 160.636 132.308 132.433 1.00 57.39  ? 367 TYR A C   1 
ATOM   1125 O O   . TYR A 1 367 ? 161.830 132.439 132.708 1.00 60.89  ? 367 TYR A O   1 
ATOM   1126 C CB  . TYR A 1 367 ? 160.292 134.620 133.352 1.00 49.25  ? 367 TYR A CB  1 
ATOM   1127 C CG  . TYR A 1 367 ? 159.392 135.812 133.573 1.00 51.16  ? 367 TYR A CG  1 
ATOM   1128 C CD1 . TYR A 1 367 ? 159.156 136.725 132.556 1.00 44.26  ? 367 TYR A CD1 1 
ATOM   1129 C CD2 . TYR A 1 367 ? 158.794 136.036 134.805 1.00 46.44  ? 367 TYR A CD2 1 
ATOM   1130 C CE1 . TYR A 1 367 ? 158.342 137.818 132.756 1.00 40.86  ? 367 TYR A CE1 1 
ATOM   1131 C CE2 . TYR A 1 367 ? 157.979 137.127 135.014 1.00 36.31  ? 367 TYR A CE2 1 
ATOM   1132 C CZ  . TYR A 1 367 ? 157.757 138.014 133.986 1.00 41.04  ? 367 TYR A CZ  1 
ATOM   1133 O OH  . TYR A 1 367 ? 156.944 139.103 134.187 1.00 42.26  ? 367 TYR A OH  1 
ATOM   1134 N N   . TYR A 1 368 ? 160.123 131.158 131.989 1.00 56.36  ? 368 TYR A N   1 
ATOM   1135 C CA  . TYR A 1 368 ? 160.935 129.946 131.985 1.00 47.11  ? 368 TYR A CA  1 
ATOM   1136 C C   . TYR A 1 368 ? 162.133 130.074 131.053 1.00 50.03  ? 368 TYR A C   1 
ATOM   1137 O O   . TYR A 1 368 ? 163.230 129.614 131.384 1.00 53.62  ? 368 TYR A O   1 
ATOM   1138 C CB  . TYR A 1 368 ? 160.082 128.734 131.609 1.00 52.69  ? 368 TYR A CB  1 
ATOM   1139 C CG  . TYR A 1 368 ? 159.491 128.772 130.219 1.00 62.35  ? 368 TYR A CG  1 
ATOM   1140 C CD1 . TYR A 1 368 ? 158.303 129.441 129.969 1.00 62.94  ? 368 TYR A CD1 1 
ATOM   1141 C CD2 . TYR A 1 368 ? 160.113 128.123 129.161 1.00 59.80  ? 368 TYR A CD2 1 
ATOM   1142 C CE1 . TYR A 1 368 ? 157.756 129.473 128.703 1.00 64.70  ? 368 TYR A CE1 1 
ATOM   1143 C CE2 . TYR A 1 368 ? 159.571 128.146 127.894 1.00 58.47  ? 368 TYR A CE2 1 
ATOM   1144 C CZ  . TYR A 1 368 ? 158.394 128.824 127.670 1.00 65.37  ? 368 TYR A CZ  1 
ATOM   1145 O OH  . TYR A 1 368 ? 157.850 128.854 126.407 1.00 68.16  ? 368 TYR A OH  1 
ATOM   1146 N N   . LYS A 1 369 ? 161.948 130.693 129.887 1.00 47.41  ? 369 LYS A N   1 
ATOM   1147 C CA  . LYS A 1 369 ? 163.069 130.867 128.968 1.00 49.91  ? 369 LYS A CA  1 
ATOM   1148 C C   . LYS A 1 369 ? 164.177 131.690 129.610 1.00 54.28  ? 369 LYS A C   1 
ATOM   1149 O O   . LYS A 1 369 ? 165.344 131.279 129.632 1.00 59.78  ? 369 LYS A O   1 
ATOM   1150 C CB  . LYS A 1 369 ? 162.594 131.530 127.676 1.00 53.09  ? 369 LYS A CB  1 
ATOM   1151 C CG  . LYS A 1 369 ? 161.667 130.678 126.835 1.00 60.21  ? 369 LYS A CG  1 
ATOM   1152 C CD  . LYS A 1 369 ? 161.219 131.426 125.593 1.00 70.76  ? 369 LYS A CD  1 
ATOM   1153 C CE  . LYS A 1 369 ? 160.303 130.573 124.734 1.00 71.12  ? 369 LYS A CE  1 
ATOM   1154 N NZ  . LYS A 1 369 ? 159.803 131.322 123.548 1.00 79.09  ? 369 LYS A NZ  1 
ATOM   1155 N N   . SER A 1 370 ? 163.821 132.855 130.156 1.00 49.24  ? 370 SER A N   1 
ATOM   1156 C CA  . SER A 1 370 ? 164.814 133.728 130.770 1.00 47.92  ? 370 SER A CA  1 
ATOM   1157 C C   . SER A 1 370 ? 165.432 133.088 132.005 1.00 42.31  ? 370 SER A C   1 
ATOM   1158 O O   . SER A 1 370 ? 166.636 133.221 132.238 1.00 50.15  ? 370 SER A O   1 
ATOM   1159 C CB  . SER A 1 370 ? 164.178 135.070 131.116 1.00 50.68  ? 370 SER A CB  1 
ATOM   1160 O OG  . SER A 1 370 ? 163.050 134.893 131.945 1.00 51.92  ? 370 SER A OG  1 
ATOM   1161 N N   . ARG A 1 371 ? 164.627 132.395 132.811 1.00 35.90  ? 371 ARG A N   1 
ATOM   1162 C CA  . ARG A 1 371 ? 165.167 131.745 134.002 1.00 41.10  ? 371 ARG A CA  1 
ATOM   1163 C C   . ARG A 1 371 ? 166.153 130.643 133.640 1.00 43.53  ? 371 ARG A C   1 
ATOM   1164 O O   . ARG A 1 371 ? 167.204 130.509 134.276 1.00 45.05  ? 371 ARG A O   1 
ATOM   1165 C CB  . ARG A 1 371 ? 164.035 131.183 134.856 1.00 49.54  ? 371 ARG A CB  1 
ATOM   1166 C CG  . ARG A 1 371 ? 163.205 132.231 135.559 1.00 49.85  ? 371 ARG A CG  1 
ATOM   1167 C CD  . ARG A 1 371 ? 162.195 131.589 136.490 1.00 50.58  ? 371 ARG A CD  1 
ATOM   1168 N NE  . ARG A 1 371 ? 161.258 130.725 135.782 1.00 57.13  ? 371 ARG A NE  1 
ATOM   1169 C CZ  . ARG A 1 371 ? 161.326 129.401 135.757 1.00 58.27  ? 371 ARG A CZ  1 
ATOM   1170 N NH1 . ARG A 1 371 ? 162.279 128.745 136.398 1.00 57.41  ? 371 ARG A NH1 1 
ATOM   1171 N NH2 . ARG A 1 371 ? 160.416 128.717 135.071 1.00 57.20  ? 371 ARG A NH2 1 
ATOM   1172 N N   . PHE A 1 372 ? 165.829 129.833 132.630 1.00 44.64  ? 372 PHE A N   1 
ATOM   1173 C CA  . PHE A 1 372 ? 166.745 128.776 132.212 1.00 42.38  ? 372 PHE A CA  1 
ATOM   1174 C C   . PHE A 1 372 ? 168.017 129.359 131.614 1.00 42.47  ? 372 PHE A C   1 
ATOM   1175 O O   . PHE A 1 372 ? 169.117 128.845 131.857 1.00 46.25  ? 372 PHE A O   1 
ATOM   1176 C CB  . PHE A 1 372 ? 166.056 127.845 131.214 1.00 46.22  ? 372 PHE A CB  1 
ATOM   1177 C CG  . PHE A 1 372 ? 164.875 127.110 131.784 1.00 47.60  ? 372 PHE A CG  1 
ATOM   1178 C CD1 . PHE A 1 372 ? 164.740 126.936 133.150 1.00 47.50  ? 372 PHE A CD1 1 
ATOM   1179 C CD2 . PHE A 1 372 ? 163.900 126.591 130.950 1.00 46.15  ? 372 PHE A CD2 1 
ATOM   1180 C CE1 . PHE A 1 372 ? 163.655 126.263 133.673 1.00 47.83  ? 372 PHE A CE1 1 
ATOM   1181 C CE2 . PHE A 1 372 ? 162.813 125.919 131.468 1.00 47.20  ? 372 PHE A CE2 1 
ATOM   1182 C CZ  . PHE A 1 372 ? 162.691 125.754 132.830 1.00 47.48  ? 372 PHE A CZ  1 
ATOM   1183 N N   . TRP A 1 373 ? 167.886 130.435 130.834 1.00 44.03  ? 373 TRP A N   1 
ATOM   1184 C CA  . TRP A 1 373 ? 169.060 131.126 130.312 1.00 43.96  ? 373 TRP A CA  1 
ATOM   1185 C C   . TRP A 1 373 ? 169.944 131.638 131.442 1.00 38.92  ? 373 TRP A C   1 
ATOM   1186 O O   . TRP A 1 373 ? 171.171 131.492 131.398 1.00 37.36  ? 373 TRP A O   1 
ATOM   1187 C CB  . TRP A 1 373 ? 168.608 132.275 129.413 1.00 44.32  ? 373 TRP A CB  1 
ATOM   1188 C CG  . TRP A 1 373 ? 169.701 133.076 128.789 1.00 45.98  ? 373 TRP A CG  1 
ATOM   1189 C CD1 . TRP A 1 373 ? 170.295 132.850 127.585 1.00 51.17  ? 373 TRP A CD1 1 
ATOM   1190 C CD2 . TRP A 1 373 ? 170.307 134.258 129.320 1.00 45.42  ? 373 TRP A CD2 1 
ATOM   1191 N NE1 . TRP A 1 373 ? 171.245 133.809 127.339 1.00 44.94  ? 373 TRP A NE1 1 
ATOM   1192 C CE2 . TRP A 1 373 ? 171.271 134.686 128.390 1.00 44.14  ? 373 TRP A CE2 1 
ATOM   1193 C CE3 . TRP A 1 373 ? 170.134 134.991 130.497 1.00 46.24  ? 373 TRP A CE3 1 
ATOM   1194 C CZ2 . TRP A 1 373 ? 172.058 135.813 128.598 1.00 45.17  ? 373 TRP A CZ2 1 
ATOM   1195 C CZ3 . TRP A 1 373 ? 170.915 136.108 130.701 1.00 44.89  ? 373 TRP A CZ3 1 
ATOM   1196 C CH2 . TRP A 1 373 ? 171.864 136.509 129.756 1.00 44.87  ? 373 TRP A CH2 1 
ATOM   1197 N N   . LEU A 1 374 ? 169.335 132.226 132.473 1.00 37.66  ? 374 LEU A N   1 
ATOM   1198 C CA  . LEU A 1 374 ? 170.102 132.726 133.608 1.00 39.04  ? 374 LEU A CA  1 
ATOM   1199 C C   . LEU A 1 374 ? 170.770 131.593 134.375 1.00 40.31  ? 374 LEU A C   1 
ATOM   1200 O O   . LEU A 1 374 ? 171.901 131.743 134.842 1.00 39.20  ? 374 LEU A O   1 
ATOM   1201 C CB  . LEU A 1 374 ? 169.202 133.542 134.535 1.00 35.09  ? 374 LEU A CB  1 
ATOM   1202 C CG  . LEU A 1 374 ? 169.889 134.098 135.784 1.00 32.17  ? 374 LEU A CG  1 
ATOM   1203 C CD1 . LEU A 1 374 ? 171.032 135.016 135.394 1.00 36.36  ? 374 LEU A CD1 1 
ATOM   1204 C CD2 . LEU A 1 374 ? 168.901 134.820 136.678 1.00 32.59  ? 374 LEU A CD2 1 
ATOM   1205 N N   . LEU A 1 375 ? 170.082 130.460 134.538 1.00 38.47  ? 375 LEU A N   1 
ATOM   1206 C CA  . LEU A 1 375 ? 170.686 129.330 135.241 1.00 36.69  ? 375 LEU A CA  1 
ATOM   1207 C C   . LEU A 1 375 ? 171.879 128.772 134.474 1.00 39.80  ? 375 LEU A C   1 
ATOM   1208 O O   . LEU A 1 375 ? 172.927 128.479 135.067 1.00 43.35  ? 375 LEU A O   1 
ATOM   1209 C CB  . LEU A 1 375 ? 169.645 128.238 135.479 1.00 33.77  ? 375 LEU A CB  1 
ATOM   1210 C CG  . LEU A 1 375 ? 168.653 128.475 136.615 1.00 40.92  ? 375 LEU A CG  1 
ATOM   1211 C CD1 . LEU A 1 375 ? 167.666 127.328 136.704 1.00 40.93  ? 375 LEU A CD1 1 
ATOM   1212 C CD2 . LEU A 1 375 ? 169.386 128.653 137.929 1.00 43.32  ? 375 LEU A CD2 1 
ATOM   1213 N N   . LYS A 1 376 ? 171.744 128.626 133.154 1.00 36.30  ? 376 LYS A N   1 
ATOM   1214 C CA  . LYS A 1 376 ? 172.874 128.186 132.345 1.00 37.22  ? 376 LYS A CA  1 
ATOM   1215 C C   . LYS A 1 376 ? 174.027 129.178 132.431 1.00 42.07  ? 376 LYS A C   1 
ATOM   1216 O O   . LYS A 1 376 ? 175.194 128.780 132.539 1.00 46.47  ? 376 LYS A O   1 
ATOM   1217 C CB  . LYS A 1 376 ? 172.436 127.997 130.893 1.00 43.51  ? 376 LYS A CB  1 
ATOM   1218 C CG  . LYS A 1 376 ? 171.355 126.948 130.701 1.00 45.92  ? 376 LYS A CG  1 
ATOM   1219 C CD  . LYS A 1 376 ? 170.813 126.970 129.282 1.00 52.81  ? 376 LYS A CD  1 
ATOM   1220 C CE  . LYS A 1 376 ? 169.633 126.024 129.127 1.00 59.80  ? 376 LYS A CE  1 
ATOM   1221 N NZ  . LYS A 1 376 ? 169.058 126.065 127.753 1.00 58.68  ? 376 LYS A NZ  1 
ATOM   1222 N N   . LEU A 1 377 ? 173.716 130.476 132.390 1.00 42.34  ? 377 LEU A N   1 
ATOM   1223 C CA  . LEU A 1 377 ? 174.755 131.494 132.479 1.00 39.71  ? 377 LEU A CA  1 
ATOM   1224 C C   . LEU A 1 377 ? 175.458 131.454 133.829 1.00 36.13  ? 377 LEU A C   1 
ATOM   1225 O O   . LEU A 1 377 ? 176.679 131.608 133.902 1.00 45.02  ? 377 LEU A O   1 
ATOM   1226 C CB  . LEU A 1 377 ? 174.152 132.874 132.229 1.00 37.83  ? 377 LEU A CB  1 
ATOM   1227 C CG  . LEU A 1 377 ? 175.153 133.988 131.947 1.00 36.83  ? 377 LEU A CG  1 
ATOM   1228 C CD1 . LEU A 1 377 ? 175.947 133.663 130.699 1.00 36.60  ? 377 LEU A CD1 1 
ATOM   1229 C CD2 . LEU A 1 377 ? 174.437 135.311 131.802 1.00 32.27  ? 377 LEU A CD2 1 
ATOM   1230 N N   . LEU A 1 378 ? 174.701 131.261 134.910 1.00 30.86  ? 378 LEU A N   1 
ATOM   1231 C CA  . LEU A 1 378 ? 175.306 131.153 136.233 1.00 35.52  ? 378 LEU A CA  1 
ATOM   1232 C C   . LEU A 1 378 ? 176.218 129.940 136.322 1.00 42.63  ? 378 LEU A C   1 
ATOM   1233 O O   . LEU A 1 378 ? 177.312 130.017 136.895 1.00 50.44  ? 378 LEU A O   1 
ATOM   1234 C CB  . LEU A 1 378 ? 174.220 131.077 137.305 1.00 34.06  ? 378 LEU A CB  1 
ATOM   1235 C CG  . LEU A 1 378 ? 173.472 132.358 137.666 1.00 38.04  ? 378 LEU A CG  1 
ATOM   1236 C CD1 . LEU A 1 378 ? 172.308 132.035 138.581 1.00 40.37  ? 378 LEU A CD1 1 
ATOM   1237 C CD2 . LEU A 1 378 ? 174.410 133.348 138.329 1.00 39.94  ? 378 LEU A CD2 1 
ATOM   1238 N N   . PHE A 1 379 ? 175.781 128.805 135.772 1.00 44.57  ? 379 PHE A N   1 
ATOM   1239 C CA  . PHE A 1 379 ? 176.625 127.615 135.769 1.00 46.06  ? 379 PHE A CA  1 
ATOM   1240 C C   . PHE A 1 379 ? 177.922 127.868 135.009 1.00 46.53  ? 379 PHE A C   1 
ATOM   1241 O O   . PHE A 1 379 ? 179.012 127.527 135.484 1.00 49.62  ? 379 PHE A O   1 
ATOM   1242 C CB  . PHE A 1 379 ? 175.858 126.436 135.167 1.00 40.26  ? 379 PHE A CB  1 
ATOM   1243 C CG  . PHE A 1 379 ? 176.702 125.217 134.934 1.00 48.87  ? 379 PHE A CG  1 
ATOM   1244 C CD1 . PHE A 1 379 ? 177.017 124.367 135.979 1.00 50.98  ? 379 PHE A CD1 1 
ATOM   1245 C CD2 . PHE A 1 379 ? 177.172 124.917 133.668 1.00 54.39  ? 379 PHE A CD2 1 
ATOM   1246 C CE1 . PHE A 1 379 ? 177.791 123.245 135.765 1.00 54.14  ? 379 PHE A CE1 1 
ATOM   1247 C CE2 . PHE A 1 379 ? 177.946 123.798 133.450 1.00 54.48  ? 379 PHE A CE2 1 
ATOM   1248 C CZ  . PHE A 1 379 ? 178.256 122.962 134.499 1.00 56.02  ? 379 PHE A CZ  1 
ATOM   1249 N N   . ARG A 1 380 ? 177.823 128.490 133.831 1.00 45.37  ? 380 ARG A N   1 
ATOM   1250 C CA  . ARG A 1 380 ? 179.021 128.789 133.051 1.00 46.08  ? 380 ARG A CA  1 
ATOM   1251 C C   . ARG A 1 380 ? 179.940 129.757 133.787 1.00 49.65  ? 380 ARG A C   1 
ATOM   1252 O O   . ARG A 1 380 ? 181.165 129.600 133.764 1.00 52.79  ? 380 ARG A O   1 
ATOM   1253 C CB  . ARG A 1 380 ? 178.638 129.363 131.689 1.00 43.81  ? 380 ARG A CB  1 
ATOM   1254 C CG  . ARG A 1 380 ? 177.854 128.421 130.806 1.00 54.59  ? 380 ARG A CG  1 
ATOM   1255 C CD  . ARG A 1 380 ? 177.534 129.082 129.481 1.00 51.27  ? 380 ARG A CD  1 
ATOM   1256 N NE  . ARG A 1 380 ? 178.747 129.432 128.752 1.00 60.31  ? 380 ARG A NE  1 
ATOM   1257 C CZ  . ARG A 1 380 ? 178.766 130.104 127.610 1.00 67.22  ? 380 ARG A CZ  1 
ATOM   1258 N NH1 . ARG A 1 380 ? 177.650 130.534 127.043 1.00 67.13  ? 380 ARG A NH1 1 
ATOM   1259 N NH2 . ARG A 1 380 ? 179.933 130.353 127.023 1.00 59.33  ? 380 ARG A NH2 1 
ATOM   1260 N N   . VAL A 1 381 ? 179.367 130.774 134.430 1.00 45.53  ? 381 VAL A N   1 
ATOM   1261 C CA  . VAL A 1 381 ? 180.173 131.780 135.113 1.00 38.02  ? 381 VAL A CA  1 
ATOM   1262 C C   . VAL A 1 381 ? 180.907 131.165 136.297 1.00 43.02  ? 381 VAL A C   1 
ATOM   1263 O O   . VAL A 1 381 ? 182.106 131.394 136.488 1.00 48.96  ? 381 VAL A O   1 
ATOM   1264 C CB  . VAL A 1 381 ? 179.292 132.966 135.545 1.00 34.44  ? 381 VAL A CB  1 
ATOM   1265 C CG1 . VAL A 1 381 ? 179.999 133.801 136.591 1.00 37.31  ? 381 VAL A CG1 1 
ATOM   1266 C CG2 . VAL A 1 381 ? 178.937 133.819 134.345 1.00 30.81  ? 381 VAL A CG2 1 
ATOM   1267 N N   . PHE A 1 382 ? 180.207 130.370 137.107 1.00 44.14  ? 382 PHE A N   1 
ATOM   1268 C CA  . PHE A 1 382 ? 180.839 129.792 138.286 1.00 47.86  ? 382 PHE A CA  1 
ATOM   1269 C C   . PHE A 1 382 ? 181.786 128.648 137.950 1.00 53.36  ? 382 PHE A C   1 
ATOM   1270 O O   . PHE A 1 382 ? 182.700 128.372 138.734 1.00 58.13  ? 382 PHE A O   1 
ATOM   1271 C CB  . PHE A 1 382 ? 179.778 129.337 139.285 1.00 44.60  ? 382 PHE A CB  1 
ATOM   1272 C CG  . PHE A 1 382 ? 179.255 130.450 140.143 1.00 43.39  ? 382 PHE A CG  1 
ATOM   1273 C CD1 . PHE A 1 382 ? 178.202 131.236 139.715 1.00 44.94  ? 382 PHE A CD1 1 
ATOM   1274 C CD2 . PHE A 1 382 ? 179.833 130.724 141.367 1.00 47.92  ? 382 PHE A CD2 1 
ATOM   1275 C CE1 . PHE A 1 382 ? 177.726 132.266 140.499 1.00 51.47  ? 382 PHE A CE1 1 
ATOM   1276 C CE2 . PHE A 1 382 ? 179.361 131.752 142.156 1.00 55.15  ? 382 PHE A CE2 1 
ATOM   1277 C CZ  . PHE A 1 382 ? 178.306 132.524 141.721 1.00 56.36  ? 382 PHE A CZ  1 
ATOM   1278 N N   . THR A 1 383 ? 181.591 127.975 136.819 1.00 53.80  ? 383 THR A N   1 
ATOM   1279 C CA  . THR A 1 383 ? 182.622 127.103 136.260 1.00 53.42  ? 383 THR A CA  1 
ATOM   1280 C C   . THR A 1 383 ? 183.372 127.875 135.174 1.00 61.11  ? 383 THR A C   1 
ATOM   1281 O O   . THR A 1 383 ? 183.236 127.631 133.975 1.00 61.82  ? 383 THR A O   1 
ATOM   1282 C CB  . THR A 1 383 ? 182.000 125.819 135.725 1.00 52.53  ? 383 THR A CB  1 
ATOM   1283 O OG1 . THR A 1 383 ? 181.035 126.140 134.718 1.00 50.84  ? 383 THR A OG1 1 
ATOM   1284 C CG2 . THR A 1 383 ? 181.316 125.059 136.847 1.00 49.57  ? 383 THR A CG2 1 
ATOM   1285 N N   . ALA A 1 384 ? 184.188 128.834 135.638 1.00 62.04  ? 384 ALA A N   1 
ATOM   1286 C CA  . ALA A 1 384 ? 184.663 129.891 134.743 1.00 63.12  ? 384 ALA A CA  1 
ATOM   1287 C C   . ALA A 1 384 ? 185.723 129.414 133.757 1.00 67.74  ? 384 ALA A C   1 
ATOM   1288 O O   . ALA A 1 384 ? 185.523 129.575 132.540 1.00 66.37  ? 384 ALA A O   1 
ATOM   1289 C CB  . ALA A 1 384 ? 185.144 131.090 135.564 1.00 50.80  ? 384 ALA A CB  1 
ATOM   1290 N N   . PRO A 1 385 ? 186.861 128.849 134.183 1.00 65.11  ? 385 PRO A N   1 
ATOM   1291 C CA  . PRO A 1 385 ? 187.936 128.572 133.216 1.00 58.77  ? 385 PRO A CA  1 
ATOM   1292 C C   . PRO A 1 385 ? 187.597 127.502 132.193 1.00 66.41  ? 385 PRO A C   1 
ATOM   1293 O O   . PRO A 1 385 ? 188.292 127.413 131.173 1.00 67.29  ? 385 PRO A O   1 
ATOM   1294 C CB  . PRO A 1 385 ? 189.101 128.130 134.108 1.00 45.44  ? 385 PRO A CB  1 
ATOM   1295 C CG  . PRO A 1 385 ? 188.445 127.533 135.283 1.00 51.51  ? 385 PRO A CG  1 
ATOM   1296 C CD  . PRO A 1 385 ? 187.214 128.358 135.528 1.00 55.47  ? 385 PRO A CD  1 
ATOM   1297 N N   . PHE A 1 386 ? 186.559 126.700 132.419 1.00 63.99  ? 386 PHE A N   1 
ATOM   1298 C CA  . PHE A 1 386 ? 186.267 125.548 131.577 1.00 61.07  ? 386 PHE A CA  1 
ATOM   1299 C C   . PHE A 1 386 ? 185.300 125.853 130.442 1.00 64.27  ? 386 PHE A C   1 
ATOM   1300 O O   . PHE A 1 386 ? 184.967 124.945 129.675 1.00 67.47  ? 386 PHE A O   1 
ATOM   1301 C CB  . PHE A 1 386 ? 185.717 124.404 132.430 1.00 59.45  ? 386 PHE A CB  1 
ATOM   1302 C CG  . PHE A 1 386 ? 186.631 123.992 133.544 1.00 65.24  ? 386 PHE A CG  1 
ATOM   1303 C CD1 . PHE A 1 386 ? 187.810 123.320 133.275 1.00 62.90  ? 386 PHE A CD1 1 
ATOM   1304 C CD2 . PHE A 1 386 ? 186.313 124.276 134.860 1.00 65.75  ? 386 PHE A CD2 1 
ATOM   1305 C CE1 . PHE A 1 386 ? 188.655 122.941 134.298 1.00 62.53  ? 386 PHE A CE1 1 
ATOM   1306 C CE2 . PHE A 1 386 ? 187.154 123.898 135.887 1.00 65.43  ? 386 PHE A CE2 1 
ATOM   1307 C CZ  . PHE A 1 386 ? 188.326 123.229 135.605 1.00 66.54  ? 386 PHE A CZ  1 
ATOM   1308 N N   . HIS A 1 387 ? 184.847 127.096 130.307 1.00 63.11  ? 387 HIS A N   1 
ATOM   1309 C CA  . HIS A 1 387 ? 183.924 127.472 129.248 1.00 62.72  ? 387 HIS A CA  1 
ATOM   1310 C C   . HIS A 1 387 ? 184.454 128.686 128.503 1.00 63.72  ? 387 HIS A C   1 
ATOM   1311 O O   . HIS A 1 387 ? 185.110 129.554 129.084 1.00 65.73  ? 387 HIS A O   1 
ATOM   1312 C CB  . HIS A 1 387 ? 182.528 127.782 129.795 1.00 61.78  ? 387 HIS A CB  1 
ATOM   1313 C CG  . HIS A 1 387 ? 181.822 126.592 130.362 1.00 61.17  ? 387 HIS A CG  1 
ATOM   1314 N ND1 . HIS A 1 387 ? 181.900 126.244 131.693 1.00 61.82  ? 387 HIS A ND1 1 
ATOM   1315 C CD2 . HIS A 1 387 ? 181.022 125.670 129.778 1.00 60.27  ? 387 HIS A CD2 1 
ATOM   1316 C CE1 . HIS A 1 387 ? 181.179 125.157 131.904 1.00 61.68  ? 387 HIS A CE1 1 
ATOM   1317 N NE2 . HIS A 1 387 ? 180.636 124.789 130.758 1.00 67.90  ? 387 HIS A NE2 1 
ATOM   1318 N N   . LYS A 1 388 ? 184.161 128.738 127.206 1.00 59.09  ? 388 LYS A N   1 
ATOM   1319 C CA  . LYS A 1 388 ? 184.518 129.905 126.413 1.00 58.11  ? 388 LYS A CA  1 
ATOM   1320 C C   . LYS A 1 388 ? 183.739 131.118 126.903 1.00 65.55  ? 388 LYS A C   1 
ATOM   1321 O O   . LYS A 1 388 ? 182.555 131.022 127.240 1.00 61.97  ? 388 LYS A O   1 
ATOM   1322 C CB  . LYS A 1 388 ? 184.232 129.651 124.935 1.00 59.84  ? 388 LYS A CB  1 
ATOM   1323 C CG  . LYS A 1 388 ? 184.709 130.758 124.014 1.00 59.55  ? 388 LYS A CG  1 
ATOM   1324 C CD  . LYS A 1 388 ? 184.238 130.532 122.589 1.00 63.68  ? 388 LYS A CD  1 
ATOM   1325 C CE  . LYS A 1 388 ? 182.721 130.486 122.518 1.00 72.62  ? 388 LYS A CE  1 
ATOM   1326 N NZ  . LYS A 1 388 ? 182.103 131.731 123.050 1.00 67.54  ? 388 LYS A NZ  1 
ATOM   1327 N N   . VAL A 1 389 ? 184.408 132.264 126.942 1.00 64.65  ? 389 VAL A N   1 
ATOM   1328 C CA  . VAL A 1 389 ? 183.854 133.477 127.530 1.00 54.53  ? 389 VAL A CA  1 
ATOM   1329 C C   . VAL A 1 389 ? 183.186 134.288 126.428 1.00 49.35  ? 389 VAL A C   1 
ATOM   1330 O O   . VAL A 1 389 ? 183.863 134.903 125.597 1.00 46.34  ? 389 VAL A O   1 
ATOM   1331 C CB  . VAL A 1 389 ? 184.932 134.299 128.248 1.00 48.68  ? 389 VAL A CB  1 
ATOM   1332 C CG1 . VAL A 1 389 ? 184.319 135.533 128.881 1.00 43.29  ? 389 VAL A CG1 1 
ATOM   1333 C CG2 . VAL A 1 389 ? 185.628 133.451 129.297 1.00 50.64  ? 389 VAL A CG2 1 
ATOM   1334 N N   . GLY A 1 390 ? 181.852 134.283 126.415 1.00 47.86  ? 390 GLY A N   1 
ATOM   1335 C CA  . GLY A 1 390 ? 181.091 135.220 125.619 1.00 42.12  ? 390 GLY A CA  1 
ATOM   1336 C C   . GLY A 1 390 ? 180.851 136.510 126.379 1.00 39.56  ? 390 GLY A C   1 
ATOM   1337 O O   . GLY A 1 390 ? 181.339 136.710 127.489 1.00 44.15  ? 390 GLY A O   1 
ATOM   1338 N N   . PHE A 1 391 ? 180.078 137.405 125.761 1.00 35.47  ? 391 PHE A N   1 
ATOM   1339 C CA  . PHE A 1 391 ? 179.797 138.674 126.424 1.00 32.61  ? 391 PHE A CA  1 
ATOM   1340 C C   . PHE A 1 391 ? 178.944 138.475 127.668 1.00 35.89  ? 391 PHE A C   1 
ATOM   1341 O O   . PHE A 1 391 ? 179.149 139.155 128.677 1.00 37.64  ? 391 PHE A O   1 
ATOM   1342 C CB  . PHE A 1 391 ? 179.112 139.652 125.474 1.00 29.93  ? 391 PHE A CB  1 
ATOM   1343 C CG  . PHE A 1 391 ? 178.844 140.995 126.096 1.00 35.07  ? 391 PHE A CG  1 
ATOM   1344 C CD1 . PHE A 1 391 ? 179.811 141.984 126.076 1.00 34.01  ? 391 PHE A CD1 1 
ATOM   1345 C CD2 . PHE A 1 391 ? 177.637 141.262 126.718 1.00 36.88  ? 391 PHE A CD2 1 
ATOM   1346 C CE1 . PHE A 1 391 ? 179.576 143.215 126.653 1.00 34.12  ? 391 PHE A CE1 1 
ATOM   1347 C CE2 . PHE A 1 391 ? 177.397 142.490 127.295 1.00 37.51  ? 391 PHE A CE2 1 
ATOM   1348 C CZ  . PHE A 1 391 ? 178.368 143.468 127.263 1.00 39.24  ? 391 PHE A CZ  1 
ATOM   1349 N N   . ALA A 1 392 ? 177.971 137.565 127.610 1.00 34.57  ? 392 ALA A N   1 
ATOM   1350 C CA  . ALA A 1 392 ? 177.069 137.379 128.740 1.00 30.06  ? 392 ALA A CA  1 
ATOM   1351 C C   . ALA A 1 392 ? 177.810 136.863 129.967 1.00 32.48  ? 392 ALA A C   1 
ATOM   1352 O O   . ALA A 1 392 ? 177.544 137.301 131.091 1.00 30.97  ? 392 ALA A O   1 
ATOM   1353 C CB  . ALA A 1 392 ? 175.937 136.431 128.353 1.00 31.98  ? 392 ALA A CB  1 
ATOM   1354 N N   . ASP A 1 393 ? 178.743 135.928 129.771 1.00 38.20  ? 393 ASP A N   1 
ATOM   1355 C CA  . ASP A 1 393 ? 179.490 135.374 130.897 1.00 32.65  ? 393 ASP A CA  1 
ATOM   1356 C C   . ASP A 1 393 ? 180.335 136.444 131.572 1.00 31.98  ? 393 ASP A C   1 
ATOM   1357 O O   . ASP A 1 393 ? 180.312 136.585 132.801 1.00 36.27  ? 393 ASP A O   1 
ATOM   1358 C CB  . ASP A 1 393 ? 180.371 134.220 130.423 1.00 39.65  ? 393 ASP A CB  1 
ATOM   1359 C CG  . ASP A 1 393 ? 179.642 133.274 129.494 1.00 51.89  ? 393 ASP A CG  1 
ATOM   1360 O OD1 . ASP A 1 393 ? 179.400 133.652 128.329 1.00 47.98  ? 393 ASP A OD1 1 
ATOM   1361 O OD2 . ASP A 1 393 ? 179.311 132.152 129.927 1.00 60.83  ? 393 ASP A OD2 1 
ATOM   1362 N N   . PHE A 1 394 ? 181.083 137.214 130.779 1.00 32.77  ? 394 PHE A N   1 
ATOM   1363 C CA  . PHE A 1 394 ? 181.891 138.292 131.337 1.00 30.26  ? 394 PHE A CA  1 
ATOM   1364 C C   . PHE A 1 394 ? 181.018 139.339 132.012 1.00 28.99  ? 394 PHE A C   1 
ATOM   1365 O O   . PHE A 1 394 ? 181.367 139.850 133.079 1.00 33.48  ? 394 PHE A O   1 
ATOM   1366 C CB  . PHE A 1 394 ? 182.747 138.930 130.241 1.00 27.53  ? 394 PHE A CB  1 
ATOM   1367 C CG  . PHE A 1 394 ? 182.710 140.433 130.238 1.00 32.41  ? 394 PHE A CG  1 
ATOM   1368 C CD1 . PHE A 1 394 ? 183.491 141.165 131.115 1.00 35.88  ? 394 PHE A CD1 1 
ATOM   1369 C CD2 . PHE A 1 394 ? 181.896 141.115 129.354 1.00 34.16  ? 394 PHE A CD2 1 
ATOM   1370 C CE1 . PHE A 1 394 ? 183.452 142.542 131.116 1.00 35.03  ? 394 PHE A CE1 1 
ATOM   1371 C CE2 . PHE A 1 394 ? 181.857 142.492 129.350 1.00 33.31  ? 394 PHE A CE2 1 
ATOM   1372 C CZ  . PHE A 1 394 ? 182.637 143.205 130.232 1.00 34.77  ? 394 PHE A CZ  1 
ATOM   1373 N N   . TRP A 1 395 ? 179.882 139.675 131.400 1.00 27.03  ? 395 TRP A N   1 
ATOM   1374 C CA  . TRP A 1 395 ? 178.995 140.689 131.959 1.00 25.19  ? 395 TRP A CA  1 
ATOM   1375 C C   . TRP A 1 395 ? 178.454 140.257 133.316 1.00 28.69  ? 395 TRP A C   1 
ATOM   1376 O O   . TRP A 1 395 ? 178.493 141.023 134.286 1.00 33.80  ? 395 TRP A O   1 
ATOM   1377 C CB  . TRP A 1 395 ? 177.859 140.959 130.974 1.00 25.49  ? 395 TRP A CB  1 
ATOM   1378 C CG  . TRP A 1 395 ? 176.912 142.047 131.362 1.00 32.08  ? 395 TRP A CG  1 
ATOM   1379 C CD1 . TRP A 1 395 ? 177.101 143.387 131.217 1.00 33.45  ? 395 TRP A CD1 1 
ATOM   1380 C CD2 . TRP A 1 395 ? 175.605 141.885 131.923 1.00 31.86  ? 395 TRP A CD2 1 
ATOM   1381 N NE1 . TRP A 1 395 ? 176.001 144.072 131.667 1.00 31.24  ? 395 TRP A NE1 1 
ATOM   1382 C CE2 . TRP A 1 395 ? 175.068 143.172 132.106 1.00 26.73  ? 395 TRP A CE2 1 
ATOM   1383 C CE3 . TRP A 1 395 ? 174.841 140.776 132.296 1.00 28.12  ? 395 TRP A CE3 1 
ATOM   1384 C CZ2 . TRP A 1 395 ? 173.803 143.380 132.643 1.00 22.87  ? 395 TRP A CZ2 1 
ATOM   1385 C CZ3 . TRP A 1 395 ? 173.589 140.985 132.829 1.00 28.98  ? 395 TRP A CZ3 1 
ATOM   1386 C CH2 . TRP A 1 395 ? 173.081 142.276 132.996 1.00 28.40  ? 395 TRP A CH2 1 
ATOM   1387 N N   . LEU A 1 396 ? 177.965 139.019 133.410 1.00 26.77  ? 396 LEU A N   1 
ATOM   1388 C CA  . LEU A 1 396 ? 177.438 138.531 134.678 1.00 22.99  ? 396 LEU A CA  1 
ATOM   1389 C C   . LEU A 1 396 ? 178.537 138.404 135.725 1.00 26.45  ? 396 LEU A C   1 
ATOM   1390 O O   . LEU A 1 396 ? 178.320 138.726 136.898 1.00 30.71  ? 396 LEU A O   1 
ATOM   1391 C CB  . LEU A 1 396 ? 176.731 137.194 134.475 1.00 25.80  ? 396 LEU A CB  1 
ATOM   1392 C CG  . LEU A 1 396 ? 176.031 136.622 135.707 1.00 29.12  ? 396 LEU A CG  1 
ATOM   1393 C CD1 . LEU A 1 396 ? 174.926 137.549 136.173 1.00 28.20  ? 396 LEU A CD1 1 
ATOM   1394 C CD2 . LEU A 1 396 ? 175.482 135.245 135.411 1.00 30.87  ? 396 LEU A CD2 1 
ATOM   1395 N N   . ALA A 1 397 ? 179.725 137.943 135.327 1.00 26.30  ? 397 ALA A N   1 
ATOM   1396 C CA  . ALA A 1 397 ? 180.817 137.828 136.287 1.00 23.47  ? 397 ALA A CA  1 
ATOM   1397 C C   . ALA A 1 397 ? 181.249 139.194 136.801 1.00 29.43  ? 397 ALA A C   1 
ATOM   1398 O O   . ALA A 1 397 ? 181.529 139.353 137.994 1.00 35.22  ? 397 ALA A O   1 
ATOM   1399 C CB  . ALA A 1 397 ? 181.995 137.090 135.658 1.00 25.14  ? 397 ALA A CB  1 
ATOM   1400 N N   . ASP A 1 398 ? 181.310 140.193 135.918 1.00 27.95  ? 398 ASP A N   1 
ATOM   1401 C CA  . ASP A 1 398 ? 181.725 141.527 136.331 1.00 25.94  ? 398 ASP A CA  1 
ATOM   1402 C C   . ASP A 1 398 ? 180.647 142.216 137.152 1.00 24.67  ? 398 ASP A C   1 
ATOM   1403 O O   . ASP A 1 398 ? 180.956 143.086 137.972 1.00 30.86  ? 398 ASP A O   1 
ATOM   1404 C CB  . ASP A 1 398 ? 182.084 142.365 135.105 1.00 27.27  ? 398 ASP A CB  1 
ATOM   1405 C CG  . ASP A 1 398 ? 182.969 143.547 135.444 1.00 35.40  ? 398 ASP A CG  1 
ATOM   1406 O OD1 . ASP A 1 398 ? 184.114 143.328 135.889 1.00 39.79  ? 398 ASP A OD1 1 
ATOM   1407 O OD2 . ASP A 1 398 ? 182.526 144.699 135.260 1.00 37.47  ? 398 ASP A OD2 1 
ATOM   1408 N N   . GLN A 1 399 ? 179.382 141.852 136.946 1.00 27.39  ? 399 GLN A N   1 
ATOM   1409 C CA  . GLN A 1 399 ? 178.315 142.380 137.784 1.00 27.64  ? 399 GLN A CA  1 
ATOM   1410 C C   . GLN A 1 399 ? 178.197 141.664 139.119 1.00 31.82  ? 399 GLN A C   1 
ATOM   1411 O O   . GLN A 1 399 ? 177.626 142.228 140.057 1.00 36.55  ? 399 GLN A O   1 
ATOM   1412 C CB  . GLN A 1 399 ? 176.986 142.313 137.046 1.00 19.47  ? 399 GLN A CB  1 
ATOM   1413 C CG  . GLN A 1 399 ? 176.874 143.348 135.963 1.00 26.94  ? 399 GLN A CG  1 
ATOM   1414 C CD  . GLN A 1 399 ? 175.452 143.585 135.578 1.00 37.73  ? 399 GLN A CD  1 
ATOM   1415 O OE1 . GLN A 1 399 ? 175.053 144.708 135.274 1.00 44.19  ? 399 GLN A OE1 1 
ATOM   1416 N NE2 . GLN A 1 399 ? 174.661 142.524 135.596 1.00 36.78  ? 399 GLN A NE2 1 
ATOM   1417 N N   . LEU A 1 400 ? 178.703 140.436 139.225 1.00 35.06  ? 400 LEU A N   1 
ATOM   1418 C CA  . LEU A 1 400 ? 178.801 139.805 140.534 1.00 33.97  ? 400 LEU A CA  1 
ATOM   1419 C C   . LEU A 1 400 ? 179.801 140.519 141.433 1.00 37.18  ? 400 LEU A C   1 
ATOM   1420 O O   . LEU A 1 400 ? 179.760 140.332 142.653 1.00 45.32  ? 400 LEU A O   1 
ATOM   1421 C CB  . LEU A 1 400 ? 179.184 138.331 140.395 1.00 33.82  ? 400 LEU A CB  1 
ATOM   1422 C CG  . LEU A 1 400 ? 178.143 137.395 139.777 1.00 36.11  ? 400 LEU A CG  1 
ATOM   1423 C CD1 . LEU A 1 400 ? 178.600 135.951 139.874 1.00 42.25  ? 400 LEU A CD1 1 
ATOM   1424 C CD2 . LEU A 1 400 ? 176.784 137.579 140.430 1.00 37.68  ? 400 LEU A CD2 1 
ATOM   1425 N N   . ASN A 1 401 ? 180.702 141.320 140.858 1.00 34.66  ? 401 ASN A N   1 
ATOM   1426 C CA  . ASN A 1 401 ? 181.572 142.166 141.667 1.00 32.79  ? 401 ASN A CA  1 
ATOM   1427 C C   . ASN A 1 401 ? 180.760 143.177 142.463 1.00 37.72  ? 401 ASN A C   1 
ATOM   1428 O O   . ASN A 1 401 ? 181.038 143.421 143.643 1.00 47.01  ? 401 ASN A O   1 
ATOM   1429 C CB  . ASN A 1 401 ? 182.584 142.890 140.778 1.00 30.88  ? 401 ASN A CB  1 
ATOM   1430 C CG  . ASN A 1 401 ? 183.608 141.956 140.171 1.00 39.81  ? 401 ASN A CG  1 
ATOM   1431 O OD1 . ASN A 1 401 ? 184.018 140.981 140.789 1.00 48.49  ? 401 ASN A OD1 1 
ATOM   1432 N ND2 . ASN A 1 401 ? 184.034 142.261 138.955 1.00 37.81  ? 401 ASN A ND2 1 
ATOM   1433 N N   . SER A 1 402 ? 179.754 143.780 141.829 1.00 33.11  ? 402 SER A N   1 
ATOM   1434 C CA  . SER A 1 402 ? 178.907 144.753 142.503 1.00 31.90  ? 402 SER A CA  1 
ATOM   1435 C C   . SER A 1 402 ? 177.950 144.105 143.490 1.00 37.92  ? 402 SER A C   1 
ATOM   1436 O O   . SER A 1 402 ? 177.490 144.776 144.419 1.00 40.90  ? 402 SER A O   1 
ATOM   1437 C CB  . SER A 1 402 ? 178.121 145.551 141.469 1.00 30.30  ? 402 SER A CB  1 
ATOM   1438 O OG  . SER A 1 402 ? 178.993 146.089 140.495 1.00 33.27  ? 402 SER A OG  1 
ATOM   1439 N N   . LEU A 1 403 ? 177.643 142.824 143.311 1.00 37.81  ? 403 LEU A N   1 
ATOM   1440 C CA  . LEU A 1 403 ? 176.714 142.104 144.166 1.00 37.49  ? 403 LEU A CA  1 
ATOM   1441 C C   . LEU A 1 403 ? 177.417 141.224 145.189 1.00 41.85  ? 403 LEU A C   1 
ATOM   1442 O O   . LEU A 1 403 ? 176.770 140.371 145.801 1.00 48.73  ? 403 LEU A O   1 
ATOM   1443 C CB  . LEU A 1 403 ? 175.769 141.256 143.316 1.00 38.24  ? 403 LEU A CB  1 
ATOM   1444 C CG  . LEU A 1 403 ? 174.846 142.023 142.369 1.00 39.81  ? 403 LEU A CG  1 
ATOM   1445 C CD1 . LEU A 1 403 ? 174.105 141.062 141.459 1.00 36.10  ? 403 LEU A CD1 1 
ATOM   1446 C CD2 . LEU A 1 403 ? 173.870 142.880 143.158 1.00 33.89  ? 403 LEU A CD2 1 
ATOM   1447 N N   . SER A 1 404 ? 178.726 141.405 145.384 1.00 41.17  ? 404 SER A N   1 
ATOM   1448 C CA  . SER A 1 404 ? 179.454 140.591 146.350 1.00 44.21  ? 404 SER A CA  1 
ATOM   1449 C C   . SER A 1 404 ? 178.911 140.754 147.762 1.00 44.37  ? 404 SER A C   1 
ATOM   1450 O O   . SER A 1 404 ? 179.110 139.866 148.599 1.00 51.28  ? 404 SER A O   1 
ATOM   1451 C CB  . SER A 1 404 ? 180.941 140.943 146.318 1.00 46.51  ? 404 SER A CB  1 
ATOM   1452 O OG  . SER A 1 404 ? 181.143 142.318 146.592 1.00 48.98  ? 404 SER A OG  1 
ATOM   1453 N N   . VAL A 1 405 ? 178.224 141.863 148.040 1.00 40.90  ? 405 VAL A N   1 
ATOM   1454 C CA  . VAL A 1 405 ? 177.583 142.037 149.339 1.00 44.66  ? 405 VAL A CA  1 
ATOM   1455 C C   . VAL A 1 405 ? 176.542 140.951 149.561 1.00 48.59  ? 405 VAL A C   1 
ATOM   1456 O O   . VAL A 1 405 ? 176.312 140.516 150.694 1.00 55.99  ? 405 VAL A O   1 
ATOM   1457 C CB  . VAL A 1 405 ? 176.966 143.442 149.447 1.00 43.30  ? 405 VAL A CB  1 
ATOM   1458 C CG1 . VAL A 1 405 ? 176.614 143.754 150.890 1.00 46.31  ? 405 VAL A CG1 1 
ATOM   1459 C CG2 . VAL A 1 405 ? 177.913 144.481 148.879 1.00 40.87  ? 405 VAL A CG2 1 
ATOM   1460 N N   . ILE A 1 406 ? 175.899 140.491 148.485 1.00 48.95  ? 406 ILE A N   1 
ATOM   1461 C CA  . ILE A 1 406 ? 174.943 139.393 148.604 1.00 47.56  ? 406 ILE A CA  1 
ATOM   1462 C C   . ILE A 1 406 ? 175.641 138.126 149.079 1.00 53.21  ? 406 ILE A C   1 
ATOM   1463 O O   . ILE A 1 406 ? 175.137 137.416 149.955 1.00 53.82  ? 406 ILE A O   1 
ATOM   1464 C CB  . ILE A 1 406 ? 174.210 139.171 147.268 1.00 43.13  ? 406 ILE A CB  1 
ATOM   1465 C CG1 . ILE A 1 406 ? 173.411 140.417 146.884 1.00 42.48  ? 406 ILE A CG1 1 
ATOM   1466 C CG2 . ILE A 1 406 ? 173.298 137.963 147.354 1.00 39.63  ? 406 ILE A CG2 1 
ATOM   1467 C CD1 . ILE A 1 406 ? 172.576 140.245 145.639 1.00 40.47  ? 406 ILE A CD1 1 
ATOM   1468 N N   . LEU A 1 407 ? 176.811 137.819 148.512 1.00 51.79  ? 407 LEU A N   1 
ATOM   1469 C CA  . LEU A 1 407 ? 177.556 136.640 148.945 1.00 51.60  ? 407 LEU A CA  1 
ATOM   1470 C C   . LEU A 1 407 ? 178.033 136.780 150.387 1.00 56.88  ? 407 LEU A C   1 
ATOM   1471 O O   . LEU A 1 407 ? 177.980 135.815 151.164 1.00 66.05  ? 407 LEU A O   1 
ATOM   1472 C CB  . LEU A 1 407 ? 178.740 136.389 148.011 1.00 54.08  ? 407 LEU A CB  1 
ATOM   1473 C CG  . LEU A 1 407 ? 178.487 135.591 146.729 1.00 62.93  ? 407 LEU A CG  1 
ATOM   1474 C CD1 . LEU A 1 407 ? 177.647 136.373 145.731 1.00 67.20  ? 407 LEU A CD1 1 
ATOM   1475 C CD2 . LEU A 1 407 ? 179.803 135.165 146.103 1.00 60.31  ? 407 LEU A CD2 1 
ATOM   1476 N N   . MET A 1 408 ? 178.511 137.968 150.762 1.00 58.98  ? 408 MET A N   1 
ATOM   1477 C CA  . MET A 1 408 ? 178.923 138.179 152.146 1.00 59.75  ? 408 MET A CA  1 
ATOM   1478 C C   . MET A 1 408 ? 177.749 138.016 153.100 1.00 64.96  ? 408 MET A C   1 
ATOM   1479 O O   . MET A 1 408 ? 177.903 137.441 154.182 1.00 73.75  ? 408 MET A O   1 
ATOM   1480 C CB  . MET A 1 408 ? 179.551 139.562 152.313 1.00 59.62  ? 408 MET A CB  1 
ATOM   1481 C CG  . MET A 1 408 ? 180.614 139.893 151.285 1.00 60.40  ? 408 MET A CG  1 
ATOM   1482 S SD  . MET A 1 408 ? 181.898 138.642 151.170 1.00 76.93  ? 408 MET A SD  1 
ATOM   1483 C CE  . MET A 1 408 ? 182.767 138.926 152.702 1.00 80.71  ? 408 MET A CE  1 
ATOM   1484 N N   . ASP A 1 409 ? 176.570 138.504 152.714 1.00 62.97  ? 409 ASP A N   1 
ATOM   1485 C CA  . ASP A 1 409 ? 175.387 138.336 153.546 1.00 63.62  ? 409 ASP A CA  1 
ATOM   1486 C C   . ASP A 1 409 ? 174.937 136.883 153.604 1.00 66.81  ? 409 ASP A C   1 
ATOM   1487 O O   . ASP A 1 409 ? 174.412 136.449 154.628 1.00 70.33  ? 409 ASP A O   1 
ATOM   1488 C CB  . ASP A 1 409 ? 174.255 139.227 153.038 1.00 58.93  ? 409 ASP A CB  1 
ATOM   1489 C CG  . ASP A 1 409 ? 174.477 140.688 153.365 1.00 60.44  ? 409 ASP A CG  1 
ATOM   1490 O OD1 . ASP A 1 409 ? 175.514 141.009 153.981 1.00 58.41  ? 409 ASP A OD1 1 
ATOM   1491 O OD2 . ASP A 1 409 ? 173.612 141.515 153.012 1.00 59.58  ? 409 ASP A OD2 1 
ATOM   1492 N N   . LEU A 1 410 ? 175.124 136.121 152.525 1.00 68.77  ? 410 LEU A N   1 
ATOM   1493 C CA  . LEU A 1 410 ? 174.829 134.691 152.580 1.00 66.77  ? 410 LEU A CA  1 
ATOM   1494 C C   . LEU A 1 410 ? 175.747 133.982 153.565 1.00 73.49  ? 410 LEU A C   1 
ATOM   1495 O O   . LEU A 1 410 ? 175.300 133.139 154.354 1.00 83.64  ? 410 LEU A O   1 
ATOM   1496 C CB  . LEU A 1 410 ? 174.959 134.066 151.191 1.00 63.99  ? 410 LEU A CB  1 
ATOM   1497 C CG  . LEU A 1 410 ? 173.913 134.454 150.146 1.00 77.89  ? 410 LEU A CG  1 
ATOM   1498 C CD1 . LEU A 1 410 ? 174.188 133.750 148.828 1.00 73.97  ? 410 LEU A CD1 1 
ATOM   1499 C CD2 . LEU A 1 410 ? 172.514 134.139 150.647 1.00 79.31  ? 410 LEU A CD2 1 
ATOM   1500 N N   . GLU A 1 411 ? 177.039 134.316 153.535 1.00 71.68  ? 411 GLU A N   1 
ATOM   1501 C CA  . GLU A 1 411 ? 177.970 133.737 154.499 1.00 72.31  ? 411 GLU A CA  1 
ATOM   1502 C C   . GLU A 1 411 ? 177.597 134.137 155.923 1.00 78.82  ? 411 GLU A C   1 
ATOM   1503 O O   . GLU A 1 411 ? 177.648 133.313 156.848 1.00 82.19  ? 411 GLU A O   1 
ATOM   1504 C CB  . GLU A 1 411 ? 179.398 134.170 154.164 1.00 70.17  ? 411 GLU A CB  1 
ATOM   1505 C CG  . GLU A 1 411 ? 180.488 133.302 154.772 1.00 78.19  ? 411 GLU A CG  1 
ATOM   1506 C CD  . GLU A 1 411 ? 180.829 133.686 156.198 1.00 88.11  ? 411 GLU A CD  1 
ATOM   1507 O OE1 . GLU A 1 411 ? 180.417 134.779 156.639 1.00 85.91  ? 411 GLU A OE1 1 
ATOM   1508 O OE2 . GLU A 1 411 ? 181.514 132.895 156.877 1.00 92.51  ? 411 GLU A OE2 1 
ATOM   1509 N N   . TYR A 1 412 ? 177.208 135.399 156.115 1.00 79.41  ? 412 TYR A N   1 
ATOM   1510 C CA  . TYR A 1 412 ? 176.788 135.858 157.433 1.00 82.30  ? 412 TYR A CA  1 
ATOM   1511 C C   . TYR A 1 412 ? 175.525 135.141 157.893 1.00 85.67  ? 412 TYR A C   1 
ATOM   1512 O O   . TYR A 1 412 ? 175.385 134.820 159.076 1.00 88.81  ? 412 TYR A O   1 
ATOM   1513 C CB  . TYR A 1 412 ? 176.573 137.370 157.421 1.00 78.66  ? 412 TYR A CB  1 
ATOM   1514 C CG  . TYR A 1 412 ? 176.165 137.932 158.763 1.00 80.78  ? 412 TYR A CG  1 
ATOM   1515 C CD1 . TYR A 1 412 ? 177.096 138.094 159.779 1.00 81.95  ? 412 TYR A CD1 1 
ATOM   1516 C CD2 . TYR A 1 412 ? 174.851 138.299 159.014 1.00 76.55  ? 412 TYR A CD2 1 
ATOM   1517 C CE1 . TYR A 1 412 ? 176.730 138.605 161.007 1.00 84.33  ? 412 TYR A CE1 1 
ATOM   1518 C CE2 . TYR A 1 412 ? 174.476 138.812 160.240 1.00 82.58  ? 412 TYR A CE2 1 
ATOM   1519 C CZ  . TYR A 1 412 ? 175.420 138.963 161.233 1.00 85.39  ? 412 TYR A CZ  1 
ATOM   1520 O OH  . TYR A 1 412 ? 175.052 139.473 162.455 1.00 87.29  ? 412 TYR A OH  1 
ATOM   1521 N N   . MET A 1 413 ? 174.586 134.898 156.976 1.00 82.82  ? 413 MET A N   1 
ATOM   1522 C CA  . MET A 1 413 ? 173.381 134.151 157.319 1.00 79.91  ? 413 MET A CA  1 
ATOM   1523 C C   . MET A 1 413 ? 173.718 132.732 157.741 1.00 85.76  ? 413 MET A C   1 
ATOM   1524 O O   . MET A 1 413 ? 173.140 132.209 158.699 1.00 88.13  ? 413 MET A O   1 
ATOM   1525 C CB  . MET A 1 413 ? 172.413 134.127 156.137 1.00 73.53  ? 413 MET A CB  1 
ATOM   1526 C CG  . MET A 1 413 ? 171.658 135.414 155.904 1.00 76.17  ? 413 MET A CG  1 
ATOM   1527 S SD  . MET A 1 413 ? 170.460 135.224 154.573 1.00 86.99  ? 413 MET A SD  1 
ATOM   1528 C CE  . MET A 1 413 ? 169.431 133.918 155.236 1.00 74.93  ? 413 MET A CE  1 
ATOM   1529 N N   . ILE A 1 414 ? 174.637 132.083 157.023 1.00 84.10  ? 414 ILE A N   1 
ATOM   1530 C CA  . ILE A 1 414 ? 175.039 130.731 157.402 1.00 82.79  ? 414 ILE A CA  1 
ATOM   1531 C C   . ILE A 1 414 ? 175.655 130.734 158.795 1.00 90.79  ? 414 ILE A C   1 
ATOM   1532 O O   . ILE A 1 414 ? 175.316 129.898 159.643 1.00 97.55  ? 414 ILE A O   1 
ATOM   1533 C CB  . ILE A 1 414 ? 176.001 130.143 156.354 1.00 83.62  ? 414 ILE A CB  1 
ATOM   1534 C CG1 . ILE A 1 414 ? 175.285 129.976 155.013 1.00 88.46  ? 414 ILE A CG1 1 
ATOM   1535 C CG2 . ILE A 1 414 ? 176.558 128.813 156.830 1.00 84.18  ? 414 ILE A CG2 1 
ATOM   1536 C CD1 . ILE A 1 414 ? 176.178 129.468 153.905 1.00 82.22  ? 414 ILE A CD1 1 
ATOM   1537 N N   . CYS A 1 415 ? 176.547 131.690 159.065 1.00 92.35  ? 415 CYS A N   1 
ATOM   1538 C CA  . CYS A 1 415 ? 177.159 131.768 160.389 1.00 97.92  ? 415 CYS A CA  1 
ATOM   1539 C C   . CYS A 1 415 ? 176.121 132.048 161.472 1.00 101.87 ? 415 CYS A C   1 
ATOM   1540 O O   . CYS A 1 415 ? 176.182 131.472 162.564 1.00 104.64 ? 415 CYS A O   1 
ATOM   1541 C CB  . CYS A 1 415 ? 178.249 132.838 160.403 1.00 96.92  ? 415 CYS A CB  1 
ATOM   1542 S SG  . CYS A 1 415 ? 179.721 132.402 159.454 1.00 121.07 ? 415 CYS A SG  1 
ATOM   1543 N N   . PHE A 1 416 ? 175.164 132.934 161.188 1.00 101.88 ? 416 PHE A N   1 
ATOM   1544 C CA  . PHE A 1 416 ? 174.149 133.292 162.173 1.00 102.29 ? 416 PHE A CA  1 
ATOM   1545 C C   . PHE A 1 416 ? 173.225 132.119 162.472 1.00 101.14 ? 416 PHE A C   1 
ATOM   1546 O O   . PHE A 1 416 ? 172.898 131.860 163.635 1.00 102.33 ? 416 PHE A O   1 
ATOM   1547 C CB  . PHE A 1 416 ? 173.348 134.496 161.673 1.00 99.92  ? 416 PHE A CB  1 
ATOM   1548 C CG  . PHE A 1 416 ? 172.487 135.139 162.723 1.00 96.24  ? 416 PHE A CG  1 
ATOM   1549 C CD1 . PHE A 1 416 ? 171.188 134.711 162.932 1.00 96.32  ? 416 PHE A CD1 1 
ATOM   1550 C CD2 . PHE A 1 416 ? 172.974 136.181 163.492 1.00 96.65  ? 416 PHE A CD2 1 
ATOM   1551 C CE1 . PHE A 1 416 ? 170.395 135.302 163.893 1.00 97.81  ? 416 PHE A CE1 1 
ATOM   1552 C CE2 . PHE A 1 416 ? 172.185 136.776 164.454 1.00 101.46 ? 416 PHE A CE2 1 
ATOM   1553 C CZ  . PHE A 1 416 ? 170.894 136.336 164.655 1.00 101.59 ? 416 PHE A CZ  1 
ATOM   1554 N N   . TYR A 1 417 ? 172.796 131.399 161.438 1.00 99.41  ? 417 TYR A N   1 
ATOM   1555 C CA  . TYR A 1 417 ? 171.918 130.253 161.618 1.00 100.49 ? 417 TYR A CA  1 
ATOM   1556 C C   . TYR A 1 417 ? 172.662 129.005 162.067 1.00 107.25 ? 417 TYR A C   1 
ATOM   1557 O O   . TYR A 1 417 ? 172.015 127.995 162.365 1.00 112.06 ? 417 TYR A O   1 
ATOM   1558 C CB  . TYR A 1 417 ? 171.157 129.962 160.323 1.00 96.00  ? 417 TYR A CB  1 
ATOM   1559 C CG  . TYR A 1 417 ? 169.983 130.883 160.084 1.00 98.74  ? 417 TYR A CG  1 
ATOM   1560 C CD1 . TYR A 1 417 ? 168.709 130.540 160.513 1.00 94.42  ? 417 TYR A CD1 1 
ATOM   1561 C CD2 . TYR A 1 417 ? 170.147 132.096 159.430 1.00 96.69  ? 417 TYR A CD2 1 
ATOM   1562 C CE1 . TYR A 1 417 ? 167.633 131.377 160.297 1.00 83.36  ? 417 TYR A CE1 1 
ATOM   1563 C CE2 . TYR A 1 417 ? 169.076 132.939 159.209 1.00 82.53  ? 417 TYR A CE2 1 
ATOM   1564 C CZ  . TYR A 1 417 ? 167.823 132.574 159.644 1.00 75.77  ? 417 TYR A CZ  1 
ATOM   1565 O OH  . TYR A 1 417 ? 166.753 133.409 159.429 1.00 77.90  ? 417 TYR A OH  1 
ATOM   1566 N N   . SER A 1 418 ? 173.992 129.038 162.107 1.00 106.13 ? 418 SER A N   1 
ATOM   1567 C CA  . SER A 1 418 ? 174.755 127.916 162.634 1.00 109.48 ? 418 SER A CA  1 
ATOM   1568 C C   . SER A 1 418 ? 175.228 128.124 164.067 1.00 112.05 ? 418 SER A C   1 
ATOM   1569 O O   . SER A 1 418 ? 175.259 127.164 164.842 1.00 116.96 ? 418 SER A O   1 
ATOM   1570 C CB  . SER A 1 418 ? 175.964 127.638 161.737 1.00 105.04 ? 418 SER A CB  1 
ATOM   1571 O OG  . SER A 1 418 ? 175.553 127.331 160.416 1.00 105.38 ? 418 SER A OG  1 
ATOM   1572 N N   . LEU A 1 419 ? 175.593 129.351 164.451 1.00 111.00 ? 419 LEU A N   1 
ATOM   1573 C CA  . LEU A 1 419 ? 176.255 129.553 165.733 1.00 112.95 ? 419 LEU A CA  1 
ATOM   1574 C C   . LEU A 1 419 ? 175.753 130.738 166.549 1.00 110.34 ? 419 LEU A C   1 
ATOM   1575 O O   . LEU A 1 419 ? 176.304 130.986 167.626 1.00 107.25 ? 419 LEU A O   1 
ATOM   1576 C CB  . LEU A 1 419 ? 177.772 129.716 165.519 1.00 113.48 ? 419 LEU A CB  1 
ATOM   1577 C CG  . LEU A 1 419 ? 178.530 128.584 164.822 1.00 112.89 ? 419 LEU A CG  1 
ATOM   1578 C CD1 . LEU A 1 419 ? 179.984 128.972 164.610 1.00 113.04 ? 419 LEU A CD1 1 
ATOM   1579 C CD2 . LEU A 1 419 ? 178.430 127.293 165.618 1.00 107.30 ? 419 LEU A CD2 1 
ATOM   1580 N N   . GLU A 1 420 ? 174.740 131.475 166.094 1.00 111.61 ? 420 GLU A N   1 
ATOM   1581 C CA  . GLU A 1 420 ? 174.348 132.715 166.756 1.00 113.20 ? 420 GLU A CA  1 
ATOM   1582 C C   . GLU A 1 420 ? 172.990 132.622 167.442 1.00 118.11 ? 420 GLU A C   1 
ATOM   1583 O O   . GLU A 1 420 ? 172.893 132.878 168.646 1.00 118.35 ? 420 GLU A O   1 
ATOM   1584 C CB  . GLU A 1 420 ? 174.358 133.871 165.748 1.00 110.68 ? 420 GLU A CB  1 
ATOM   1585 C CG  . GLU A 1 420 ? 175.742 134.247 165.239 1.00 112.10 ? 420 GLU A CG  1 
ATOM   1586 C CD  . GLU A 1 420 ? 176.567 135.000 166.266 1.00 116.23 ? 420 GLU A CD  1 
ATOM   1587 O OE1 . GLU A 1 420 ? 175.986 135.494 167.256 1.00 111.99 ? 420 GLU A OE1 1 
ATOM   1588 O OE2 . GLU A 1 420 ? 177.798 135.101 166.081 1.00 114.76 ? 420 GLU A OE2 1 
ATOM   1589 N N   . LEU A 1 421 ? 171.934 132.267 166.716 1.00 116.27 ? 421 LEU A N   1 
ATOM   1590 C CA  . LEU A 1 421 ? 170.609 132.258 167.317 1.00 116.23 ? 421 LEU A CA  1 
ATOM   1591 C C   . LEU A 1 421 ? 170.364 130.943 168.056 1.00 123.22 ? 421 LEU A C   1 
ATOM   1592 O O   . LEU A 1 421 ? 171.148 129.994 167.977 1.00 125.61 ? 421 LEU A O   1 
ATOM   1593 C CB  . LEU A 1 421 ? 169.530 132.497 166.261 1.00 113.43 ? 421 LEU A CB  1 
ATOM   1594 C CG  . LEU A 1 421 ? 168.979 131.311 165.467 1.00 113.57 ? 421 LEU A CG  1 
ATOM   1595 C CD1 . LEU A 1 421 ? 167.845 131.771 164.575 1.00 105.94 ? 421 LEU A CD1 1 
ATOM   1596 C CD2 . LEU A 1 421 ? 170.062 130.655 164.641 1.00 112.93 ? 421 LEU A CD2 1 
ATOM   1597 N N   . LYS A 1 422 ? 169.246 130.896 168.782 1.00 124.24 ? 422 LYS A N   1 
ATOM   1598 C CA  . LYS A 1 422 ? 168.967 129.797 169.697 1.00 128.42 ? 422 LYS A CA  1 
ATOM   1599 C C   . LYS A 1 422 ? 168.053 128.725 169.116 1.00 129.89 ? 422 LYS A C   1 
ATOM   1600 O O   . LYS A 1 422 ? 167.988 127.626 169.679 1.00 131.61 ? 422 LYS A O   1 
ATOM   1601 C CB  . LYS A 1 422 ? 168.345 130.343 170.988 1.00 127.59 ? 422 LYS A CB  1 
ATOM   1602 C CG  . LYS A 1 422 ? 169.061 131.558 171.556 1.00 126.80 ? 422 LYS A CG  1 
ATOM   1603 C CD  . LYS A 1 422 ? 170.523 131.255 171.847 1.00 126.39 ? 422 LYS A CD  1 
ATOM   1604 C CE  . LYS A 1 422 ? 171.258 132.496 172.329 1.00 121.00 ? 422 LYS A CE  1 
ATOM   1605 N NZ  . LYS A 1 422 ? 172.701 132.226 172.575 1.00 118.28 ? 422 LYS A NZ  1 
ATOM   1606 N N   . TRP A 1 423 ? 167.333 129.026 168.032 1.00 126.38 ? 423 TRP A N   1 
ATOM   1607 C CA  . TRP A 1 423 ? 166.460 128.087 167.328 1.00 125.72 ? 423 TRP A CA  1 
ATOM   1608 C C   . TRP A 1 423 ? 165.228 127.693 168.137 1.00 132.36 ? 423 TRP A C   1 
ATOM   1609 O O   . TRP A 1 423 ? 164.369 126.961 167.635 1.00 133.02 ? 423 TRP A O   1 
ATOM   1610 C CB  . TRP A 1 423 ? 167.213 126.815 166.925 1.00 124.72 ? 423 TRP A CB  1 
ATOM   1611 C CG  . TRP A 1 423 ? 168.407 127.036 166.061 1.00 125.49 ? 423 TRP A CG  1 
ATOM   1612 C CD1 . TRP A 1 423 ? 168.414 127.344 164.732 1.00 118.64 ? 423 TRP A CD1 1 
ATOM   1613 C CD2 . TRP A 1 423 ? 169.779 126.934 166.457 1.00 130.80 ? 423 TRP A CD2 1 
ATOM   1614 N NE1 . TRP A 1 423 ? 169.706 127.451 164.279 1.00 124.60 ? 423 TRP A NE1 1 
ATOM   1615 C CE2 . TRP A 1 423 ? 170.563 127.206 165.320 1.00 129.63 ? 423 TRP A CE2 1 
ATOM   1616 C CE3 . TRP A 1 423 ? 170.421 126.644 167.666 1.00 129.03 ? 423 TRP A CE3 1 
ATOM   1617 C CZ2 . TRP A 1 423 ? 171.956 127.197 165.355 1.00 124.68 ? 423 TRP A CZ2 1 
ATOM   1618 C CZ3 . TRP A 1 423 ? 171.803 126.637 167.699 1.00 128.33 ? 423 TRP A CZ3 1 
ATOM   1619 C CH2 . TRP A 1 423 ? 172.556 126.912 166.551 1.00 124.64 ? 423 TRP A CH2 1 
ATOM   1620 N N   . ASP A 1 424 ? 165.122 128.161 169.381 1.00 135.39 ? 424 ASP A N   1 
ATOM   1621 C CA  . ASP A 1 424 ? 163.986 127.827 170.226 1.00 133.96 ? 424 ASP A CA  1 
ATOM   1622 C C   . ASP A 1 424 ? 163.262 129.041 170.786 1.00 136.16 ? 424 ASP A C   1 
ATOM   1623 O O   . ASP A 1 424 ? 162.163 128.885 171.330 1.00 135.78 ? 424 ASP A O   1 
ATOM   1624 C CB  . ASP A 1 424 ? 164.425 126.920 171.389 1.00 131.51 ? 424 ASP A CB  1 
ATOM   1625 C CG  . ASP A 1 424 ? 165.469 127.569 172.279 1.00 133.06 ? 424 ASP A CG  1 
ATOM   1626 O OD1 . ASP A 1 424 ? 165.887 128.707 171.987 1.00 131.90 ? 424 ASP A OD1 1 
ATOM   1627 O OD2 . ASP A 1 424 ? 165.873 126.936 173.277 1.00 137.00 ? 424 ASP A OD2 1 
ATOM   1628 N N   . GLU A 1 425 ? 163.839 130.233 170.673 1.00 138.30 ? 425 GLU A N   1 
ATOM   1629 C CA  . GLU A 1 425 ? 163.207 131.462 171.120 1.00 139.36 ? 425 GLU A CA  1 
ATOM   1630 C C   . GLU A 1 425 ? 163.149 132.440 169.956 1.00 137.64 ? 425 GLU A C   1 
ATOM   1631 O O   . GLU A 1 425 ? 163.817 132.262 168.934 1.00 136.42 ? 425 GLU A O   1 
ATOM   1632 C CB  . GLU A 1 425 ? 163.960 132.090 172.302 1.00 138.10 ? 425 GLU A CB  1 
ATOM   1633 C CG  . GLU A 1 425 ? 163.974 131.234 173.557 1.00 139.27 ? 425 GLU A CG  1 
ATOM   1634 C CD  . GLU A 1 425 ? 164.729 131.887 174.699 1.00 141.02 ? 425 GLU A CD  1 
ATOM   1635 O OE1 . GLU A 1 425 ? 165.359 132.941 174.471 1.00 141.98 ? 425 GLU A OE1 1 
ATOM   1636 O OE2 . GLU A 1 425 ? 164.693 131.347 175.824 1.00 137.61 ? 425 GLU A OE2 1 
ATOM   1637 N N   . SER A 1 426 ? 162.339 133.484 170.120 1.00 135.76 ? 426 SER A N   1 
ATOM   1638 C CA  . SER A 1 426 ? 162.215 134.500 169.084 1.00 134.45 ? 426 SER A CA  1 
ATOM   1639 C C   . SER A 1 426 ? 163.459 135.378 169.062 1.00 134.22 ? 426 SER A C   1 
ATOM   1640 O O   . SER A 1 426 ? 163.393 136.572 169.374 1.00 128.65 ? 426 SER A O   1 
ATOM   1641 C CB  . SER A 1 426 ? 160.961 135.348 169.308 1.00 126.24 ? 426 SER A CB  1 
ATOM   1642 O OG  . SER A 1 426 ? 160.827 136.333 168.299 1.00 118.51 ? 426 SER A OG  1 
ATOM   1643 N N   . LYS A 1 427 ? 164.599 134.792 168.691 1.00 133.40 ? 427 LYS A N   1 
ATOM   1644 C CA  . LYS A 1 427 ? 165.884 135.478 168.709 1.00 131.96 ? 427 LYS A CA  1 
ATOM   1645 C C   . LYS A 1 427 ? 166.375 135.837 167.311 1.00 129.39 ? 427 LYS A C   1 
ATOM   1646 O O   . LYS A 1 427 ? 167.564 136.117 167.131 1.00 126.38 ? 427 LYS A O   1 
ATOM   1647 C CB  . LYS A 1 427 ? 166.927 134.629 169.435 1.00 131.99 ? 427 LYS A CB  1 
ATOM   1648 C CG  . LYS A 1 427 ? 166.680 134.495 170.929 1.00 135.02 ? 427 LYS A CG  1 
ATOM   1649 C CD  . LYS A 1 427 ? 166.689 135.854 171.610 1.00 131.00 ? 427 LYS A CD  1 
ATOM   1650 C CE  . LYS A 1 427 ? 166.435 135.727 173.103 1.00 127.94 ? 427 LYS A CE  1 
ATOM   1651 N NZ  . LYS A 1 427 ? 166.461 137.052 173.783 1.00 126.37 ? 427 LYS A NZ  1 
ATOM   1652 N N   . GLY A 1 428 ? 165.486 135.827 166.315 1.00 124.87 ? 428 GLY A N   1 
ATOM   1653 C CA  . GLY A 1 428 ? 165.862 136.326 165.004 1.00 113.59 ? 428 GLY A CA  1 
ATOM   1654 C C   . GLY A 1 428 ? 166.271 137.783 165.044 1.00 116.26 ? 428 GLY A C   1 
ATOM   1655 O O   . GLY A 1 428 ? 167.160 138.206 164.301 1.00 109.90 ? 428 GLY A O   1 
ATOM   1656 N N   . LEU A 1 429 ? 165.629 138.566 165.907 1.00 119.33 ? 429 LEU A N   1 
ATOM   1657 C CA  . LEU A 1 429 ? 166.019 139.944 166.188 1.00 114.67 ? 429 LEU A CA  1 
ATOM   1658 C C   . LEU A 1 429 ? 166.706 139.937 167.551 1.00 120.26 ? 429 LEU A C   1 
ATOM   1659 O O   . LEU A 1 429 ? 166.048 139.832 168.589 1.00 120.96 ? 429 LEU A O   1 
ATOM   1660 C CB  . LEU A 1 429 ? 164.802 140.863 166.158 1.00 109.84 ? 429 LEU A CB  1 
ATOM   1661 C CG  . LEU A 1 429 ? 165.010 142.376 166.217 1.00 109.62 ? 429 LEU A CG  1 
ATOM   1662 C CD1 . LEU A 1 429 ? 163.894 143.076 165.467 1.00 97.41  ? 429 LEU A CD1 1 
ATOM   1663 C CD2 . LEU A 1 429 ? 165.057 142.861 167.653 1.00 116.55 ? 429 LEU A CD2 1 
ATOM   1664 N N   . LEU A 1 430 ? 168.032 140.043 167.542 1.00 120.90 ? 430 LEU A N   1 
ATOM   1665 C CA  . LEU A 1 430 ? 168.803 139.912 168.767 1.00 125.06 ? 430 LEU A CA  1 
ATOM   1666 C C   . LEU A 1 430 ? 168.523 141.078 169.715 1.00 127.24 ? 430 LEU A C   1 
ATOM   1667 O O   . LEU A 1 430 ? 168.148 142.168 169.278 1.00 121.96 ? 430 LEU A O   1 
ATOM   1668 C CB  . LEU A 1 430 ? 170.295 139.847 168.451 1.00 120.70 ? 430 LEU A CB  1 
ATOM   1669 C CG  . LEU A 1 430 ? 170.779 138.567 167.768 1.00 117.39 ? 430 LEU A CG  1 
ATOM   1670 C CD1 . LEU A 1 430 ? 172.293 138.577 167.626 1.00 108.04 ? 430 LEU A CD1 1 
ATOM   1671 C CD2 . LEU A 1 430 ? 170.318 137.342 168.541 1.00 118.19 ? 430 LEU A CD2 1 
ATOM   1672 N N   . PRO A 1 431 ? 168.681 140.866 171.032 1.00 127.90 ? 431 PRO A N   1 
ATOM   1673 C CA  . PRO A 1 431 ? 168.477 141.932 172.018 1.00 127.80 ? 431 PRO A CA  1 
ATOM   1674 C C   . PRO A 1 431 ? 169.652 142.901 172.091 1.00 129.24 ? 431 PRO A C   1 
ATOM   1675 O O   . PRO A 1 431 ? 169.964 143.379 173.182 1.00 127.46 ? 431 PRO A O   1 
ATOM   1676 C CB  . PRO A 1 431 ? 168.326 141.163 173.331 1.00 126.38 ? 431 PRO A CB  1 
ATOM   1677 C CG  . PRO A 1 431 ? 169.141 139.938 173.126 1.00 121.82 ? 431 PRO A CG  1 
ATOM   1678 C CD  . PRO A 1 431 ? 168.968 139.572 171.677 1.00 122.24 ? 431 PRO A CD  1 
ATOM   1679 N N   . GLY A 1 446 ? 189.678 134.874 156.990 1.00 69.45  ? 446 GLY A N   1 
ATOM   1680 C CA  . GLY A 1 446 ? 189.635 133.457 156.681 1.00 78.95  ? 446 GLY A CA  1 
ATOM   1681 C C   . GLY A 1 446 ? 188.632 133.122 155.597 1.00 80.84  ? 446 GLY A C   1 
ATOM   1682 O O   . GLY A 1 446 ? 188.876 133.372 154.417 1.00 76.71  ? 446 GLY A O   1 
ATOM   1683 N N   . VAL A 1 447 ? 187.498 132.546 156.001 1.00 82.39  ? 447 VAL A N   1 
ATOM   1684 C CA  . VAL A 1 447 ? 186.438 132.242 155.044 1.00 79.13  ? 447 VAL A CA  1 
ATOM   1685 C C   . VAL A 1 447 ? 185.864 133.525 154.461 1.00 76.61  ? 447 VAL A C   1 
ATOM   1686 O O   . VAL A 1 447 ? 185.586 133.609 153.259 1.00 75.81  ? 447 VAL A O   1 
ATOM   1687 C CB  . VAL A 1 447 ? 185.346 131.385 155.709 1.00 79.16  ? 447 VAL A CB  1 
ATOM   1688 C CG1 . VAL A 1 447 ? 184.217 131.109 154.732 1.00 76.04  ? 447 VAL A CG1 1 
ATOM   1689 C CG2 . VAL A 1 447 ? 185.935 130.085 156.228 1.00 75.77  ? 447 VAL A CG2 1 
ATOM   1690 N N   . ARG A 1 448 ? 185.672 134.542 155.303 1.00 72.77  ? 448 ARG A N   1 
ATOM   1691 C CA  . ARG A 1 448 ? 185.082 135.798 154.850 1.00 71.95  ? 448 ARG A CA  1 
ATOM   1692 C C   . ARG A 1 448 ? 185.946 136.471 153.788 1.00 75.65  ? 448 ARG A C   1 
ATOM   1693 O O   . ARG A 1 448 ? 185.442 136.930 152.755 1.00 75.83  ? 448 ARG A O   1 
ATOM   1694 C CB  . ARG A 1 448 ? 184.869 136.720 156.050 1.00 77.24  ? 448 ARG A CB  1 
ATOM   1695 C CG  . ARG A 1 448 ? 184.441 138.126 155.698 1.00 83.14  ? 448 ARG A CG  1 
ATOM   1696 C CD  . ARG A 1 448 ? 183.637 138.746 156.826 1.00 89.16  ? 448 ARG A CD  1 
ATOM   1697 N NE  . ARG A 1 448 ? 182.380 138.039 157.037 1.00 94.77  ? 448 ARG A NE  1 
ATOM   1698 C CZ  . ARG A 1 448 ? 181.235 138.359 156.450 1.00 95.60  ? 448 ARG A CZ  1 
ATOM   1699 N NH1 . ARG A 1 448 ? 181.147 139.385 155.620 1.00 89.45  ? 448 ARG A NH1 1 
ATOM   1700 N NH2 . ARG A 1 448 ? 180.150 137.633 156.703 1.00 96.25  ? 448 ARG A NH2 1 
ATOM   1701 N N   . ALA A 1 449 ? 187.258 136.528 154.023 1.00 74.54  ? 449 ALA A N   1 
ATOM   1702 C CA  . ALA A 1 449 ? 188.167 137.130 153.056 1.00 69.90  ? 449 ALA A CA  1 
ATOM   1703 C C   . ALA A 1 449 ? 188.212 136.362 151.743 1.00 69.60  ? 449 ALA A C   1 
ATOM   1704 O O   . ALA A 1 449 ? 188.305 136.985 150.680 1.00 64.85  ? 449 ALA A O   1 
ATOM   1705 C CB  . ALA A 1 449 ? 189.572 137.232 153.648 1.00 64.02  ? 449 ALA A CB  1 
ATOM   1706 N N   . ILE A 1 450 ? 188.159 135.031 151.789 1.00 66.32  ? 450 ILE A N   1 
ATOM   1707 C CA  . ILE A 1 450 ? 188.129 134.251 150.558 1.00 65.81  ? 450 ILE A CA  1 
ATOM   1708 C C   . ILE A 1 450 ? 186.823 134.469 149.804 1.00 66.30  ? 450 ILE A C   1 
ATOM   1709 O O   . ILE A 1 450 ? 186.828 134.605 148.575 1.00 66.49  ? 450 ILE A O   1 
ATOM   1710 C CB  . ILE A 1 450 ? 188.360 132.763 150.867 1.00 67.32  ? 450 ILE A CB  1 
ATOM   1711 C CG1 . ILE A 1 450 ? 189.764 132.555 151.432 1.00 68.58  ? 450 ILE A CG1 1 
ATOM   1712 C CG2 . ILE A 1 450 ? 188.160 131.917 149.622 1.00 70.59  ? 450 ILE A CG2 1 
ATOM   1713 C CD1 . ILE A 1 450 ? 190.087 131.114 151.746 1.00 70.54  ? 450 ILE A CD1 1 
ATOM   1714 N N   . VAL A 1 451 ? 185.692 134.513 150.515 1.00 63.47  ? 451 VAL A N   1 
ATOM   1715 C CA  . VAL A 1 451 ? 184.401 134.757 149.874 1.00 59.63  ? 451 VAL A CA  1 
ATOM   1716 C C   . VAL A 1 451 ? 184.319 136.138 149.248 1.00 62.85  ? 451 VAL A C   1 
ATOM   1717 O O   . VAL A 1 451 ? 183.710 136.287 148.180 1.00 62.92  ? 451 VAL A O   1 
ATOM   1718 C CB  . VAL A 1 451 ? 183.258 134.551 150.887 1.00 63.36  ? 451 VAL A CB  1 
ATOM   1719 C CG1 . VAL A 1 451 ? 181.935 135.040 150.326 1.00 59.75  ? 451 VAL A CG1 1 
ATOM   1720 C CG2 . VAL A 1 451 ? 183.150 133.084 151.260 1.00 66.87  ? 451 VAL A CG2 1 
ATOM   1721 N N   . GLN A 1 452 ? 184.935 137.147 149.861 1.00 64.32  ? 452 GLN A N   1 
ATOM   1722 C CA  . GLN A 1 452 ? 184.934 138.486 149.284 1.00 57.82  ? 452 GLN A CA  1 
ATOM   1723 C C   . GLN A 1 452 ? 185.578 138.540 147.907 1.00 56.23  ? 452 GLN A C   1 
ATOM   1724 O O   . GLN A 1 452 ? 185.171 139.358 147.074 1.00 57.58  ? 452 GLN A O   1 
ATOM   1725 C CB  . GLN A 1 452 ? 185.651 139.463 150.216 1.00 61.16  ? 452 GLN A CB  1 
ATOM   1726 C CG  . GLN A 1 452 ? 185.601 140.907 149.755 1.00 64.45  ? 452 GLN A CG  1 
ATOM   1727 C CD  . GLN A 1 452 ? 184.192 141.461 149.719 1.00 73.80  ? 452 GLN A CD  1 
ATOM   1728 O OE1 . GLN A 1 452 ? 183.493 141.475 150.730 1.00 74.06  ? 452 GLN A OE1 1 
ATOM   1729 N NE2 . GLN A 1 452 ? 183.767 141.921 148.549 1.00 70.03  ? 452 GLN A NE2 1 
ATOM   1730 N N   . CYS A 1 453 ? 186.560 137.683 147.639 1.00 56.20  ? 453 CYS A N   1 
ATOM   1731 C CA  . CYS A 1 453 ? 187.281 137.699 146.374 1.00 52.61  ? 453 CYS A CA  1 
ATOM   1732 C C   . CYS A 1 453 ? 186.727 136.716 145.352 1.00 52.96  ? 453 CYS A C   1 
ATOM   1733 O O   . CYS A 1 453 ? 187.338 136.547 144.293 1.00 52.54  ? 453 CYS A O   1 
ATOM   1734 C CB  . CYS A 1 453 ? 188.765 137.403 146.607 1.00 47.01  ? 453 CYS A CB  1 
ATOM   1735 S SG  . CYS A 1 453 ? 189.606 138.595 147.660 1.00 57.95  ? 453 CYS A SG  1 
ATOM   1736 N N   . ILE A 1 454 ? 185.601 136.061 145.641 1.00 49.28  ? 454 ILE A N   1 
ATOM   1737 C CA  . ILE A 1 454 ? 185.056 135.078 144.701 1.00 45.26  ? 454 ILE A CA  1 
ATOM   1738 C C   . ILE A 1 454 ? 184.697 135.697 143.355 1.00 43.89  ? 454 ILE A C   1 
ATOM   1739 O O   . ILE A 1 454 ? 185.109 135.147 142.321 1.00 50.69  ? 454 ILE A O   1 
ATOM   1740 C CB  . ILE A 1 454 ? 183.875 134.328 145.344 1.00 48.99  ? 454 ILE A CB  1 
ATOM   1741 C CG1 . ILE A 1 454 ? 184.368 133.408 146.459 1.00 54.12  ? 454 ILE A CG1 1 
ATOM   1742 C CG2 . ILE A 1 454 ? 183.115 133.532 144.297 1.00 42.50  ? 454 ILE A CG2 1 
ATOM   1743 C CD1 . ILE A 1 454 ? 183.273 132.576 147.086 1.00 54.78  ? 454 ILE A CD1 1 
ATOM   1744 N N   . PRO A 1 455 ? 183.937 136.799 143.278 1.00 37.33  ? 455 PRO A N   1 
ATOM   1745 C CA  . PRO A 1 455 ? 183.675 137.383 141.950 1.00 37.17  ? 455 PRO A CA  1 
ATOM   1746 C C   . PRO A 1 455 ? 184.934 137.865 141.254 1.00 39.97  ? 455 PRO A C   1 
ATOM   1747 O O   . PRO A 1 455 ? 185.079 137.701 140.032 1.00 45.02  ? 455 PRO A O   1 
ATOM   1748 C CB  . PRO A 1 455 ? 182.714 138.538 142.263 1.00 38.84  ? 455 PRO A CB  1 
ATOM   1749 C CG  . PRO A 1 455 ? 182.130 138.207 143.584 1.00 46.19  ? 455 PRO A CG  1 
ATOM   1750 C CD  . PRO A 1 455 ? 183.223 137.536 144.334 1.00 48.17  ? 455 PRO A CD  1 
ATOM   1751 N N   . ALA A 1 456 ? 185.862 138.451 142.012 1.00 39.80  ? 456 ALA A N   1 
ATOM   1752 C CA  . ALA A 1 456 ? 187.138 138.854 141.438 1.00 35.85  ? 456 ALA A CA  1 
ATOM   1753 C C   . ALA A 1 456 ? 187.914 137.644 140.941 1.00 41.06  ? 456 ALA A C   1 
ATOM   1754 O O   . ALA A 1 456 ? 188.563 137.705 139.893 1.00 44.48  ? 456 ALA A O   1 
ATOM   1755 C CB  . ALA A 1 456 ? 187.952 139.636 142.465 1.00 40.95  ? 456 ALA A CB  1 
ATOM   1756 N N   . TRP A 1 457 ? 187.856 136.533 141.679 1.00 42.59  ? 457 TRP A N   1 
ATOM   1757 C CA  . TRP A 1 457 ? 188.506 135.306 141.228 1.00 37.30  ? 457 TRP A CA  1 
ATOM   1758 C C   . TRP A 1 457 ? 187.890 134.794 139.935 1.00 37.73  ? 457 TRP A C   1 
ATOM   1759 O O   . TRP A 1 457 ? 188.608 134.363 139.025 1.00 41.33  ? 457 TRP A O   1 
ATOM   1760 C CB  . TRP A 1 457 ? 188.426 134.240 142.319 1.00 36.06  ? 457 TRP A CB  1 
ATOM   1761 C CG  . TRP A 1 457 ? 188.881 132.890 141.873 1.00 43.02  ? 457 TRP A CG  1 
ATOM   1762 C CD1 . TRP A 1 457 ? 188.094 131.813 141.593 1.00 44.58  ? 457 TRP A CD1 1 
ATOM   1763 C CD2 . TRP A 1 457 ? 190.231 132.470 141.651 1.00 46.16  ? 457 TRP A CD2 1 
ATOM   1764 N NE1 . TRP A 1 457 ? 188.870 130.746 141.213 1.00 47.19  ? 457 TRP A NE1 1 
ATOM   1765 C CE2 . TRP A 1 457 ? 190.186 131.124 141.240 1.00 47.77  ? 457 TRP A CE2 1 
ATOM   1766 C CE3 . TRP A 1 457 ? 191.473 133.101 141.761 1.00 47.01  ? 457 TRP A CE3 1 
ATOM   1767 C CZ2 . TRP A 1 457 ? 191.335 130.399 140.940 1.00 48.57  ? 457 TRP A CZ2 1 
ATOM   1768 C CZ3 . TRP A 1 457 ? 192.611 132.379 141.462 1.00 49.58  ? 457 TRP A CZ3 1 
ATOM   1769 C CH2 . TRP A 1 457 ? 192.534 131.042 141.056 1.00 50.49  ? 457 TRP A CH2 1 
ATOM   1770 N N   . LEU A 1 458 ? 186.559 134.822 139.841 1.00 35.46  ? 458 LEU A N   1 
ATOM   1771 C CA  . LEU A 1 458 ? 185.888 134.373 138.626 1.00 36.38  ? 458 LEU A CA  1 
ATOM   1772 C C   . LEU A 1 458 ? 186.306 135.218 137.433 1.00 34.65  ? 458 LEU A C   1 
ATOM   1773 O O   . LEU A 1 458 ? 186.624 134.691 136.362 1.00 34.97  ? 458 LEU A O   1 
ATOM   1774 C CB  . LEU A 1 458 ? 184.373 134.424 138.811 1.00 31.21  ? 458 LEU A CB  1 
ATOM   1775 C CG  . LEU A 1 458 ? 183.763 133.471 139.836 1.00 35.02  ? 458 LEU A CG  1 
ATOM   1776 C CD1 . LEU A 1 458 ? 182.278 133.738 139.979 1.00 35.99  ? 458 LEU A CD1 1 
ATOM   1777 C CD2 . LEU A 1 458 ? 184.011 132.033 139.432 1.00 42.30  ? 458 LEU A CD2 1 
ATOM   1778 N N   . ARG A 1 459 ? 186.331 136.539 137.607 1.00 34.44  ? 459 ARG A N   1 
ATOM   1779 C CA  . ARG A 1 459 ? 186.746 137.408 136.511 1.00 30.86  ? 459 ARG A CA  1 
ATOM   1780 C C   . ARG A 1 459 ? 188.222 137.233 136.174 1.00 35.40  ? 459 ARG A C   1 
ATOM   1781 O O   . ARG A 1 459 ? 188.600 137.311 135.001 1.00 40.81  ? 459 ARG A O   1 
ATOM   1782 C CB  . ARG A 1 459 ? 186.433 138.860 136.853 1.00 26.03  ? 459 ARG A CB  1 
ATOM   1783 C CG  . ARG A 1 459 ? 185.017 139.268 136.505 1.00 24.85  ? 459 ARG A CG  1 
ATOM   1784 C CD  . ARG A 1 459 ? 184.953 139.908 135.130 1.00 24.95  ? 459 ARG A CD  1 
ATOM   1785 N NE  . ARG A 1 459 ? 185.336 138.996 134.061 1.00 26.93  ? 459 ARG A NE  1 
ATOM   1786 C CZ  . ARG A 1 459 ? 185.894 139.376 132.920 1.00 28.23  ? 459 ARG A CZ  1 
ATOM   1787 N NH1 . ARG A 1 459 ? 186.180 140.644 132.680 1.00 29.47  ? 459 ARG A NH1 1 
ATOM   1788 N NH2 . ARG A 1 459 ? 186.180 138.460 132.001 1.00 31.28  ? 459 ARG A NH2 1 
ATOM   1789 N N   . PHE A 1 460 ? 189.062 136.977 137.176 1.00 32.96  ? 460 PHE A N   1 
ATOM   1790 C CA  . PHE A 1 460 ? 190.484 136.759 136.930 1.00 33.88  ? 460 PHE A CA  1 
ATOM   1791 C C   . PHE A 1 460 ? 190.716 135.500 136.102 1.00 40.40  ? 460 PHE A C   1 
ATOM   1792 O O   . PHE A 1 460 ? 191.477 135.518 135.126 1.00 44.96  ? 460 PHE A O   1 
ATOM   1793 C CB  . PHE A 1 460 ? 191.218 136.685 138.270 1.00 37.81  ? 460 PHE A CB  1 
ATOM   1794 C CG  . PHE A 1 460 ? 192.685 136.398 138.153 1.00 40.31  ? 460 PHE A CG  1 
ATOM   1795 C CD1 . PHE A 1 460 ? 193.559 137.365 137.699 1.00 43.26  ? 460 PHE A CD1 1 
ATOM   1796 C CD2 . PHE A 1 460 ? 193.193 135.169 138.527 1.00 41.25  ? 460 PHE A CD2 1 
ATOM   1797 C CE1 . PHE A 1 460 ? 194.909 137.105 137.602 1.00 43.03  ? 460 PHE A CE1 1 
ATOM   1798 C CE2 . PHE A 1 460 ? 194.541 134.904 138.432 1.00 46.36  ? 460 PHE A CE2 1 
ATOM   1799 C CZ  . PHE A 1 460 ? 195.400 135.874 137.969 1.00 46.32  ? 460 PHE A CZ  1 
ATOM   1800 N N   . ILE A 1 461 ? 190.060 134.396 136.468 1.00 39.63  ? 461 ILE A N   1 
ATOM   1801 C CA  . ILE A 1 461 ? 190.248 133.170 135.695 1.00 36.85  ? 461 ILE A CA  1 
ATOM   1802 C C   . ILE A 1 461 ? 189.584 133.280 134.327 1.00 37.60  ? 461 ILE A C   1 
ATOM   1803 O O   . ILE A 1 461 ? 190.064 132.687 133.355 1.00 43.55  ? 461 ILE A O   1 
ATOM   1804 C CB  . ILE A 1 461 ? 189.758 131.932 136.469 1.00 34.57  ? 461 ILE A CB  1 
ATOM   1805 C CG1 . ILE A 1 461 ? 188.322 132.110 136.949 1.00 42.22  ? 461 ILE A CG1 1 
ATOM   1806 C CG2 . ILE A 1 461 ? 190.694 131.624 137.627 1.00 34.78  ? 461 ILE A CG2 1 
ATOM   1807 C CD1 . ILE A 1 461 ? 187.894 131.081 137.973 1.00 43.33  ? 461 ILE A CD1 1 
ATOM   1808 N N   . GLN A 1 462 ? 188.490 134.040 134.210 1.00 34.79  ? 462 GLN A N   1 
ATOM   1809 C CA  . GLN A 1 462 ? 187.921 134.287 132.889 1.00 34.84  ? 462 GLN A CA  1 
ATOM   1810 C C   . GLN A 1 462 ? 188.891 135.058 132.005 1.00 37.27  ? 462 GLN A C   1 
ATOM   1811 O O   . GLN A 1 462 ? 189.029 134.759 130.815 1.00 41.75  ? 462 GLN A O   1 
ATOM   1812 C CB  . GLN A 1 462 ? 186.600 135.042 133.009 1.00 31.07  ? 462 GLN A CB  1 
ATOM   1813 C CG  . GLN A 1 462 ? 185.433 134.195 133.465 1.00 38.61  ? 462 GLN A CG  1 
ATOM   1814 C CD  . GLN A 1 462 ? 184.119 134.934 133.372 1.00 34.97  ? 462 GLN A CD  1 
ATOM   1815 O OE1 . GLN A 1 462 ? 184.047 136.018 132.798 1.00 34.72  ? 462 GLN A OE1 1 
ATOM   1816 N NE2 . GLN A 1 462 ? 183.070 134.353 133.937 1.00 36.26  ? 462 GLN A NE2 1 
ATOM   1817 N N   . CYS A 1 463 ? 189.567 136.063 132.566 1.00 38.20  ? 463 CYS A N   1 
ATOM   1818 C CA  . CYS A 1 463 ? 190.552 136.812 131.793 1.00 40.90  ? 463 CYS A CA  1 
ATOM   1819 C C   . CYS A 1 463 ? 191.733 135.933 131.400 1.00 47.35  ? 463 CYS A C   1 
ATOM   1820 O O   . CYS A 1 463 ? 192.253 136.045 130.284 1.00 53.31  ? 463 CYS A O   1 
ATOM   1821 C CB  . CYS A 1 463 ? 191.024 138.031 132.582 1.00 40.25  ? 463 CYS A CB  1 
ATOM   1822 S SG  . CYS A 1 463 ? 189.770 139.313 132.770 1.00 57.08  ? 463 CYS A SG  1 
ATOM   1823 N N   . LEU A 1 464 ? 192.173 135.054 132.304 1.00 46.82  ? 464 LEU A N   1 
ATOM   1824 C CA  . LEU A 1 464 ? 193.237 134.116 131.956 1.00 42.52  ? 464 LEU A CA  1 
ATOM   1825 C C   . LEU A 1 464 ? 192.807 133.184 130.828 1.00 46.51  ? 464 LEU A C   1 
ATOM   1826 O O   . LEU A 1 464 ? 193.585 132.912 129.906 1.00 53.46  ? 464 LEU A O   1 
ATOM   1827 C CB  . LEU A 1 464 ? 193.658 133.312 133.183 1.00 35.47  ? 464 LEU A CB  1 
ATOM   1828 C CG  . LEU A 1 464 ? 194.354 134.086 134.299 1.00 39.26  ? 464 LEU A CG  1 
ATOM   1829 C CD1 . LEU A 1 464 ? 194.822 133.135 135.381 1.00 42.76  ? 464 LEU A CD1 1 
ATOM   1830 C CD2 . LEU A 1 464 ? 195.517 134.886 133.749 1.00 44.83  ? 464 LEU A CD2 1 
ATOM   1831 N N   . ARG A 1 465 ? 191.570 132.684 130.885 1.00 42.66  ? 465 ARG A N   1 
ATOM   1832 C CA  . ARG A 1 465 ? 191.059 131.834 129.814 1.00 47.41  ? 465 ARG A CA  1 
ATOM   1833 C C   . ARG A 1 465 ? 190.989 132.590 128.493 1.00 51.21  ? 465 ARG A C   1 
ATOM   1834 O O   . ARG A 1 465 ? 191.309 132.038 127.435 1.00 56.05  ? 465 ARG A O   1 
ATOM   1835 C CB  . ARG A 1 465 ? 189.682 131.291 130.197 1.00 52.41  ? 465 ARG A CB  1 
ATOM   1836 C CG  . ARG A 1 465 ? 188.911 130.653 129.050 1.00 61.33  ? 465 ARG A CG  1 
ATOM   1837 C CD  . ARG A 1 465 ? 189.632 129.438 128.492 1.00 67.41  ? 465 ARG A CD  1 
ATOM   1838 N NE  . ARG A 1 465 ? 188.864 128.788 127.438 1.00 65.42  ? 465 ARG A NE  1 
ATOM   1839 C CZ  . ARG A 1 465 ? 188.024 127.783 127.639 1.00 66.16  ? 465 ARG A CZ  1 
ATOM   1840 N NH1 . ARG A 1 465 ? 187.826 127.280 128.846 1.00 64.15  ? 465 ARG A NH1 1 
ATOM   1841 N NH2 . ARG A 1 465 ? 187.365 127.272 126.604 1.00 67.86  ? 465 ARG A NH2 1 
ATOM   1842 N N   . ARG A 1 466 ? 190.558 133.851 128.535 1.00 53.23  ? 466 ARG A N   1 
ATOM   1843 C CA  . ARG A 1 466 ? 190.497 134.655 127.319 1.00 53.90  ? 466 ARG A CA  1 
ATOM   1844 C C   . ARG A 1 466 ? 191.884 134.873 126.730 1.00 58.62  ? 466 ARG A C   1 
ATOM   1845 O O   . ARG A 1 466 ? 192.065 134.812 125.509 1.00 61.54  ? 466 ARG A O   1 
ATOM   1846 C CB  . ARG A 1 466 ? 189.818 135.989 127.614 1.00 48.14  ? 466 ARG A CB  1 
ATOM   1847 C CG  . ARG A 1 466 ? 188.321 135.878 127.806 1.00 45.52  ? 466 ARG A CG  1 
ATOM   1848 C CD  . ARG A 1 466 ? 187.592 136.411 126.595 1.00 46.83  ? 466 ARG A CD  1 
ATOM   1849 N NE  . ARG A 1 466 ? 187.660 137.864 126.536 1.00 41.15  ? 466 ARG A NE  1 
ATOM   1850 C CZ  . ARG A 1 466 ? 187.317 138.587 125.481 1.00 40.33  ? 466 ARG A CZ  1 
ATOM   1851 N NH1 . ARG A 1 466 ? 186.904 138.021 124.361 1.00 41.60  ? 466 ARG A NH1 1 
ATOM   1852 N NH2 . ARG A 1 466 ? 187.395 139.911 125.550 1.00 44.98  ? 466 ARG A NH2 1 
ATOM   1853 N N   . TYR A 1 467 ? 192.877 135.138 127.584 1.00 59.79  ? 467 TYR A N   1 
ATOM   1854 C CA  . TYR A 1 467 ? 194.247 135.272 127.098 1.00 62.51  ? 467 TYR A CA  1 
ATOM   1855 C C   . TYR A 1 467 ? 194.745 133.968 126.491 1.00 68.65  ? 467 TYR A C   1 
ATOM   1856 O O   . TYR A 1 467 ? 195.423 133.974 125.458 1.00 75.78  ? 467 TYR A O   1 
ATOM   1857 C CB  . TYR A 1 467 ? 195.172 135.717 128.228 1.00 60.58  ? 467 TYR A CB  1 
ATOM   1858 C CG  . TYR A 1 467 ? 196.634 135.505 127.913 1.00 68.31  ? 467 TYR A CG  1 
ATOM   1859 C CD1 . TYR A 1 467 ? 197.266 136.250 126.928 1.00 69.13  ? 467 TYR A CD1 1 
ATOM   1860 C CD2 . TYR A 1 467 ? 197.382 134.559 128.599 1.00 69.66  ? 467 TYR A CD2 1 
ATOM   1861 C CE1 . TYR A 1 467 ? 198.600 136.058 126.634 1.00 72.73  ? 467 TYR A CE1 1 
ATOM   1862 C CE2 . TYR A 1 467 ? 198.718 134.361 128.313 1.00 73.90  ? 467 TYR A CE2 1 
ATOM   1863 C CZ  . TYR A 1 467 ? 199.321 135.113 127.329 1.00 77.94  ? 467 TYR A CZ  1 
ATOM   1864 O OH  . TYR A 1 467 ? 200.652 134.921 127.038 1.00 78.64  ? 467 TYR A OH  1 
ATOM   1865 N N   . ARG A 1 468 ? 194.427 132.840 127.126 1.00 64.74  ? 468 ARG A N   1 
ATOM   1866 C CA  . ARG A 1 468 ? 194.834 131.545 126.593 1.00 65.82  ? 468 ARG A CA  1 
ATOM   1867 C C   . ARG A 1 468 ? 194.208 131.289 125.229 1.00 69.09  ? 468 ARG A C   1 
ATOM   1868 O O   . ARG A 1 468 ? 194.867 130.772 124.320 1.00 73.89  ? 468 ARG A O   1 
ATOM   1869 C CB  . ARG A 1 468 ? 194.451 130.444 127.579 1.00 64.71  ? 468 ARG A CB  1 
ATOM   1870 C CG  . ARG A 1 468 ? 194.733 129.032 127.114 1.00 64.07  ? 468 ARG A CG  1 
ATOM   1871 C CD  . ARG A 1 468 ? 193.952 128.047 127.966 1.00 70.07  ? 468 ARG A CD  1 
ATOM   1872 N NE  . ARG A 1 468 ? 193.992 128.417 129.376 1.00 73.74  ? 468 ARG A NE  1 
ATOM   1873 C CZ  . ARG A 1 468 ? 193.278 127.834 130.328 1.00 75.33  ? 468 ARG A CZ  1 
ATOM   1874 N NH1 . ARG A 1 468 ? 192.448 126.840 130.059 1.00 75.96  ? 468 ARG A NH1 1 
ATOM   1875 N NH2 . ARG A 1 468 ? 193.398 128.260 131.583 1.00 62.41  ? 468 ARG A NH2 1 
ATOM   1876 N N   . ASP A 1 469 ? 192.933 131.644 125.067 1.00 65.63  ? 469 ASP A N   1 
ATOM   1877 C CA  . ASP A 1 469 ? 192.249 131.394 123.803 1.00 72.57  ? 469 ASP A CA  1 
ATOM   1878 C C   . ASP A 1 469 ? 192.748 132.318 122.699 1.00 73.81  ? 469 ASP A C   1 
ATOM   1879 O O   . ASP A 1 469 ? 192.974 131.875 121.567 1.00 74.34  ? 469 ASP A O   1 
ATOM   1880 C CB  . ASP A 1 469 ? 190.739 131.547 123.982 1.00 74.53  ? 469 ASP A CB  1 
ATOM   1881 C CG  . ASP A 1 469 ? 190.164 130.540 124.953 1.00 78.44  ? 469 ASP A CG  1 
ATOM   1882 O OD1 . ASP A 1 469 ? 190.945 129.743 125.513 1.00 73.81  ? 469 ASP A OD1 1 
ATOM   1883 O OD2 . ASP A 1 469 ? 188.932 130.543 125.157 1.00 79.61  ? 469 ASP A OD2 1 
ATOM   1884 N N   . THR A 1 470 ? 192.925 133.605 123.002 1.00 71.78  ? 470 THR A N   1 
ATOM   1885 C CA  . THR A 1 470 ? 193.237 134.591 121.976 1.00 72.71  ? 470 THR A CA  1 
ATOM   1886 C C   . THR A 1 470 ? 194.721 134.915 121.867 1.00 70.98  ? 470 THR A C   1 
ATOM   1887 O O   . THR A 1 470 ? 195.153 135.403 120.817 1.00 72.00  ? 470 THR A O   1 
ATOM   1888 C CB  . THR A 1 470 ? 192.459 135.885 122.237 1.00 74.12  ? 470 THR A CB  1 
ATOM   1889 O OG1 . THR A 1 470 ? 191.179 135.563 122.794 1.00 72.31  ? 470 THR A OG1 1 
ATOM   1890 C CG2 . THR A 1 470 ? 192.248 136.651 120.940 1.00 72.35  ? 470 THR A CG2 1 
ATOM   1891 N N   . LYS A 1 471 ? 195.506 134.652 122.914 1.00 71.57  ? 471 LYS A N   1 
ATOM   1892 C CA  . LYS A 1 471 ? 196.945 134.925 122.924 1.00 77.44  ? 471 LYS A CA  1 
ATOM   1893 C C   . LYS A 1 471 ? 197.246 136.403 122.673 1.00 80.27  ? 471 LYS A C   1 
ATOM   1894 O O   . LYS A 1 471 ? 198.209 136.746 121.988 1.00 81.40  ? 471 LYS A O   1 
ATOM   1895 C CB  . LYS A 1 471 ? 197.690 134.041 121.921 1.00 78.07  ? 471 LYS A CB  1 
ATOM   1896 C CG  . LYS A 1 471 ? 197.732 132.573 122.312 1.00 79.66  ? 471 LYS A CG  1 
ATOM   1897 C CD  . LYS A 1 471 ? 198.382 132.391 123.675 1.00 84.65  ? 471 LYS A CD  1 
ATOM   1898 C CE  . LYS A 1 471 ? 198.386 130.932 124.100 1.00 88.40  ? 471 LYS A CE  1 
ATOM   1899 N NZ  . LYS A 1 471 ? 199.017 130.750 125.437 1.00 83.57  ? 471 LYS A NZ  1 
ATOM   1900 N N   . ARG A 1 472 ? 196.420 137.282 123.235 1.00 78.20  ? 472 ARG A N   1 
ATOM   1901 C CA  . ARG A 1 472 ? 196.663 138.719 123.227 1.00 73.40  ? 472 ARG A CA  1 
ATOM   1902 C C   . ARG A 1 472 ? 196.957 139.154 124.656 1.00 74.83  ? 472 ARG A C   1 
ATOM   1903 O O   . ARG A 1 472 ? 196.088 139.057 125.529 1.00 67.88  ? 472 ARG A O   1 
ATOM   1904 C CB  . ARG A 1 472 ? 195.468 139.482 122.657 1.00 68.44  ? 472 ARG A CB  1 
ATOM   1905 C CG  . ARG A 1 472 ? 195.013 138.981 121.299 1.00 67.32  ? 472 ARG A CG  1 
ATOM   1906 C CD  . ARG A 1 472 ? 194.871 140.107 120.285 1.00 68.77  ? 472 ARG A CD  1 
ATOM   1907 N NE  . ARG A 1 472 ? 193.872 141.095 120.676 1.00 73.00  ? 472 ARG A NE  1 
ATOM   1908 C CZ  . ARG A 1 472 ? 194.156 142.303 121.143 1.00 73.74  ? 472 ARG A CZ  1 
ATOM   1909 N NH1 . ARG A 1 472 ? 195.405 142.710 121.294 1.00 74.20  ? 472 ARG A NH1 1 
ATOM   1910 N NH2 . ARG A 1 472 ? 193.160 143.125 121.462 1.00 63.76  ? 472 ARG A NH2 1 
ATOM   1911 N N   . ALA A 1 473 ? 198.181 139.626 124.890 1.00 72.84  ? 473 ALA A N   1 
ATOM   1912 C CA  . ALA A 1 473 ? 198.624 139.900 126.252 1.00 67.23  ? 473 ALA A CA  1 
ATOM   1913 C C   . ALA A 1 473 ? 198.028 141.189 126.805 1.00 68.26  ? 473 ALA A C   1 
ATOM   1914 O O   . ALA A 1 473 ? 197.738 141.272 128.002 1.00 68.89  ? 473 ALA A O   1 
ATOM   1915 C CB  . ALA A 1 473 ? 200.150 139.959 126.303 1.00 63.16  ? 473 ALA A CB  1 
ATOM   1916 N N   . PHE A 1 474 ? 197.844 142.205 125.958 1.00 66.73  ? 474 PHE A N   1 
ATOM   1917 C CA  . PHE A 1 474 ? 197.429 143.514 126.463 1.00 64.28  ? 474 PHE A CA  1 
ATOM   1918 C C   . PHE A 1 474 ? 196.014 143.514 127.029 1.00 67.64  ? 474 PHE A C   1 
ATOM   1919 O O   . PHE A 1 474 ? 195.849 143.798 128.228 1.00 71.85  ? 474 PHE A O   1 
ATOM   1920 C CB  . PHE A 1 474 ? 197.606 144.572 125.370 1.00 61.78  ? 474 PHE A CB  1 
ATOM   1921 C CG  . PHE A 1 474 ? 196.718 145.770 125.544 1.00 60.07  ? 474 PHE A CG  1 
ATOM   1922 C CD1 . PHE A 1 474 ? 196.892 146.629 126.613 1.00 61.35  ? 474 PHE A CD1 1 
ATOM   1923 C CD2 . PHE A 1 474 ? 195.707 146.034 124.639 1.00 60.17  ? 474 PHE A CD2 1 
ATOM   1924 C CE1 . PHE A 1 474 ? 196.073 147.726 126.777 1.00 68.01  ? 474 PHE A CE1 1 
ATOM   1925 C CE2 . PHE A 1 474 ? 194.886 147.131 124.795 1.00 56.89  ? 474 PHE A CE2 1 
ATOM   1926 C CZ  . PHE A 1 474 ? 195.070 147.978 125.865 1.00 64.16  ? 474 PHE A CZ  1 
ATOM   1927 N N   . PRO A 1 475 ? 194.961 143.215 126.259 1.00 62.99  ? 475 PRO A N   1 
ATOM   1928 C CA  . PRO A 1 475 ? 193.605 143.411 126.788 1.00 56.60  ? 475 PRO A CA  1 
ATOM   1929 C C   . PRO A 1 475 ? 193.156 142.346 127.771 1.00 60.16  ? 475 PRO A C   1 
ATOM   1930 O O   . PRO A 1 475 ? 192.088 142.507 128.377 1.00 64.41  ? 475 PRO A O   1 
ATOM   1931 C CB  . PRO A 1 475 ? 192.742 143.383 125.526 1.00 51.61  ? 475 PRO A CB  1 
ATOM   1932 C CG  . PRO A 1 475 ? 193.447 142.423 124.652 1.00 62.70  ? 475 PRO A CG  1 
ATOM   1933 C CD  . PRO A 1 475 ? 194.923 142.593 124.921 1.00 59.87  ? 475 PRO A CD  1 
ATOM   1934 N N   . HIS A 1 476 ? 193.923 141.271 127.955 1.00 58.86  ? 476 HIS A N   1 
ATOM   1935 C CA  . HIS A 1 476 ? 193.469 140.138 128.745 1.00 53.74  ? 476 HIS A CA  1 
ATOM   1936 C C   . HIS A 1 476 ? 194.328 139.829 129.959 1.00 52.87  ? 476 HIS A C   1 
ATOM   1937 O O   . HIS A 1 476 ? 193.871 139.087 130.834 1.00 51.79  ? 476 HIS A O   1 
ATOM   1938 C CB  . HIS A 1 476 ? 193.382 138.879 127.871 1.00 52.30  ? 476 HIS A CB  1 
ATOM   1939 C CG  . HIS A 1 476 ? 192.453 139.019 126.707 1.00 51.22  ? 476 HIS A CG  1 
ATOM   1940 N ND1 . HIS A 1 476 ? 192.896 139.098 125.405 1.00 59.42  ? 476 HIS A ND1 1 
ATOM   1941 C CD2 . HIS A 1 476 ? 191.103 139.099 126.650 1.00 46.61  ? 476 HIS A CD2 1 
ATOM   1942 C CE1 . HIS A 1 476 ? 191.860 139.217 124.596 1.00 54.76  ? 476 HIS A CE1 1 
ATOM   1943 N NE2 . HIS A 1 476 ? 190.760 139.222 125.326 1.00 48.52  ? 476 HIS A NE2 1 
ATOM   1944 N N   . LEU A 1 477 ? 195.543 140.364 130.046 1.00 54.17  ? 477 LEU A N   1 
ATOM   1945 C CA  . LEU A 1 477 ? 196.356 140.209 131.245 1.00 53.43  ? 477 LEU A CA  1 
ATOM   1946 C C   . LEU A 1 477 ? 196.403 141.468 132.095 1.00 54.80  ? 477 LEU A C   1 
ATOM   1947 O O   . LEU A 1 477 ? 196.551 141.374 133.319 1.00 53.41  ? 477 LEU A O   1 
ATOM   1948 C CB  . LEU A 1 477 ? 197.783 139.796 130.873 1.00 54.42  ? 477 LEU A CB  1 
ATOM   1949 C CG  . LEU A 1 477 ? 197.942 138.370 130.345 1.00 59.14  ? 477 LEU A CG  1 
ATOM   1950 C CD1 . LEU A 1 477 ? 199.404 138.052 130.089 1.00 66.82  ? 477 LEU A CD1 1 
ATOM   1951 C CD2 . LEU A 1 477 ? 197.335 137.371 131.317 1.00 54.59  ? 477 LEU A CD2 1 
ATOM   1952 N N   . VAL A 1 478 ? 196.269 142.642 131.474 1.00 52.69  ? 478 VAL A N   1 
ATOM   1953 C CA  . VAL A 1 478 ? 196.218 143.888 132.233 1.00 50.92  ? 478 VAL A CA  1 
ATOM   1954 C C   . VAL A 1 478 ? 194.995 143.902 133.143 1.00 52.44  ? 478 VAL A C   1 
ATOM   1955 O O   . VAL A 1 478 ? 195.085 144.229 134.332 1.00 51.05  ? 478 VAL A O   1 
ATOM   1956 C CB  . VAL A 1 478 ? 196.236 145.095 131.278 1.00 45.71  ? 478 VAL A CB  1 
ATOM   1957 C CG1 . VAL A 1 478 ? 196.024 146.384 132.041 1.00 45.01  ? 478 VAL A CG1 1 
ATOM   1958 C CG2 . VAL A 1 478 ? 197.552 145.143 130.525 1.00 45.18  ? 478 VAL A CG2 1 
ATOM   1959 N N   . ASN A 1 479 ? 193.833 143.516 132.610 1.00 49.55  ? 479 ASN A N   1 
ATOM   1960 C CA  . ASN A 1 479 ? 192.651 143.443 133.460 1.00 44.37  ? 479 ASN A CA  1 
ATOM   1961 C C   . ASN A 1 479 ? 192.701 142.254 134.409 1.00 46.79  ? 479 ASN A C   1 
ATOM   1962 O O   . ASN A 1 479 ? 192.075 142.302 135.472 1.00 55.74  ? 479 ASN A O   1 
ATOM   1963 C CB  . ASN A 1 479 ? 191.380 143.400 132.613 1.00 39.93  ? 479 ASN A CB  1 
ATOM   1964 C CG  . ASN A 1 479 ? 191.373 142.260 131.642 1.00 46.25  ? 479 ASN A CG  1 
ATOM   1965 O OD1 . ASN A 1 479 ? 192.418 141.698 131.329 1.00 55.53  ? 479 ASN A OD1 1 
ATOM   1966 N ND2 . ASN A 1 479 ? 190.193 141.908 131.150 1.00 42.63  ? 479 ASN A ND2 1 
ATOM   1967 N N   . ALA A 1 480 ? 193.441 141.198 134.070 1.00 46.43  ? 480 ALA A N   1 
ATOM   1968 C CA  . ALA A 1 480 ? 193.676 140.141 135.047 1.00 46.32  ? 480 ALA A CA  1 
ATOM   1969 C C   . ALA A 1 480 ? 194.418 140.685 136.262 1.00 46.70  ? 480 ALA A C   1 
ATOM   1970 O O   . ALA A 1 480 ? 194.052 140.394 137.407 1.00 42.83  ? 480 ALA A O   1 
ATOM   1971 C CB  . ALA A 1 480 ? 194.451 138.992 134.406 1.00 45.92  ? 480 ALA A CB  1 
ATOM   1972 N N   . GLY A 1 481 ? 195.452 141.497 136.032 1.00 45.44  ? 481 GLY A N   1 
ATOM   1973 C CA  . GLY A 1 481 ? 196.100 142.182 137.138 1.00 41.11  ? 481 GLY A CA  1 
ATOM   1974 C C   . GLY A 1 481 ? 195.179 143.156 137.845 1.00 44.82  ? 481 GLY A C   1 
ATOM   1975 O O   . GLY A 1 481 ? 195.267 143.331 139.064 1.00 51.10  ? 481 GLY A O   1 
ATOM   1976 N N   . LYS A 1 482 ? 194.288 143.803 137.091 1.00 39.99  ? 482 LYS A N   1 
ATOM   1977 C CA  . LYS A 1 482 ? 193.296 144.688 137.692 1.00 36.45  ? 482 LYS A CA  1 
ATOM   1978 C C   . LYS A 1 482 ? 192.426 143.941 138.693 1.00 39.32  ? 482 LYS A C   1 
ATOM   1979 O O   . LYS A 1 482 ? 192.126 144.455 139.776 1.00 43.23  ? 482 LYS A O   1 
ATOM   1980 C CB  . LYS A 1 482 ? 192.432 145.316 136.600 1.00 33.57  ? 482 LYS A CB  1 
ATOM   1981 C CG  . LYS A 1 482 ? 191.203 146.039 137.111 1.00 32.35  ? 482 LYS A CG  1 
ATOM   1982 C CD  . LYS A 1 482 ? 190.399 146.621 135.965 1.00 37.75  ? 482 LYS A CD  1 
ATOM   1983 C CE  . LYS A 1 482 ? 189.448 145.605 135.372 1.00 33.48  ? 482 LYS A CE  1 
ATOM   1984 N NZ  . LYS A 1 482 ? 188.280 145.389 136.259 1.00 28.72  ? 482 LYS A NZ  1 
ATOM   1985 N N   . TYR A 1 483 ? 192.004 142.727 138.342 1.00 40.22  ? 483 TYR A N   1 
ATOM   1986 C CA  . TYR A 1 483 ? 191.198 141.931 139.262 1.00 34.46  ? 483 TYR A CA  1 
ATOM   1987 C C   . TYR A 1 483 ? 192.035 141.357 140.398 1.00 42.23  ? 483 TYR A C   1 
ATOM   1988 O O   . TYR A 1 483 ? 191.523 141.171 141.506 1.00 47.22  ? 483 TYR A O   1 
ATOM   1989 C CB  . TYR A 1 483 ? 190.478 140.816 138.505 1.00 31.82  ? 483 TYR A CB  1 
ATOM   1990 C CG  . TYR A 1 483 ? 189.358 141.327 137.632 1.00 32.88  ? 483 TYR A CG  1 
ATOM   1991 C CD1 . TYR A 1 483 ? 188.230 141.903 138.192 1.00 32.05  ? 483 TYR A CD1 1 
ATOM   1992 C CD2 . TYR A 1 483 ? 189.429 141.240 136.251 1.00 31.46  ? 483 TYR A CD2 1 
ATOM   1993 C CE1 . TYR A 1 483 ? 187.208 142.378 137.405 1.00 26.60  ? 483 TYR A CE1 1 
ATOM   1994 C CE2 . TYR A 1 483 ? 188.413 141.715 135.457 1.00 28.46  ? 483 TYR A CE2 1 
ATOM   1995 C CZ  . TYR A 1 483 ? 187.305 142.283 136.039 1.00 29.53  ? 483 TYR A CZ  1 
ATOM   1996 O OH  . TYR A 1 483 ? 186.285 142.756 135.251 1.00 38.75  ? 483 TYR A OH  1 
ATOM   1997 N N   . SER A 1 484 ? 193.315 141.070 140.149 1.00 44.85  ? 484 SER A N   1 
ATOM   1998 C CA  . SER A 1 484 ? 194.184 140.566 141.209 1.00 41.24  ? 484 SER A CA  1 
ATOM   1999 C C   . SER A 1 484 ? 194.531 141.638 142.234 1.00 45.60  ? 484 SER A C   1 
ATOM   2000 O O   . SER A 1 484 ? 194.888 141.303 143.373 1.00 50.29  ? 484 SER A O   1 
ATOM   2001 C CB  . SER A 1 484 ? 195.465 139.989 140.613 1.00 45.31  ? 484 SER A CB  1 
ATOM   2002 O OG  . SER A 1 484 ? 196.274 141.012 140.068 1.00 45.51  ? 484 SER A OG  1 
ATOM   2003 N N   . THR A 1 485 ? 194.465 142.915 141.849 1.00 43.78  ? 485 THR A N   1 
ATOM   2004 C CA  . THR A 1 485 ? 194.629 143.977 142.836 1.00 45.95  ? 485 THR A CA  1 
ATOM   2005 C C   . THR A 1 485 ? 193.588 143.864 143.940 1.00 52.88  ? 485 THR A C   1 
ATOM   2006 O O   . THR A 1 485 ? 193.865 144.218 145.092 1.00 56.46  ? 485 THR A O   1 
ATOM   2007 C CB  . THR A 1 485 ? 194.545 145.352 142.173 1.00 41.83  ? 485 THR A CB  1 
ATOM   2008 O OG1 . THR A 1 485 ? 193.355 145.436 141.382 1.00 46.33  ? 485 THR A OG1 1 
ATOM   2009 C CG2 . THR A 1 485 ? 195.757 145.596 141.294 1.00 42.19  ? 485 THR A CG2 1 
ATOM   2010 N N   . THR A 1 486 ? 192.395 143.361 143.614 1.00 48.75  ? 486 THR A N   1 
ATOM   2011 C CA  . THR A 1 486 ? 191.398 143.089 144.643 1.00 49.70  ? 486 THR A CA  1 
ATOM   2012 C C   . THR A 1 486 ? 191.886 142.020 145.614 1.00 54.04  ? 486 THR A C   1 
ATOM   2013 O O   . THR A 1 486 ? 191.720 142.159 146.832 1.00 59.78  ? 486 THR A O   1 
ATOM   2014 C CB  . THR A 1 486 ? 190.077 142.667 143.999 1.00 47.20  ? 486 THR A CB  1 
ATOM   2015 O OG1 . THR A 1 486 ? 189.571 143.741 143.197 1.00 42.76  ? 486 THR A OG1 1 
ATOM   2016 C CG2 . THR A 1 486 ? 189.050 142.310 145.062 1.00 51.56  ? 486 THR A CG2 1 
ATOM   2017 N N   . PHE A 1 487 ? 192.500 140.950 145.097 1.00 48.79  ? 487 PHE A N   1 
ATOM   2018 C CA  . PHE A 1 487 ? 193.058 139.925 145.975 1.00 50.65  ? 487 PHE A CA  1 
ATOM   2019 C C   . PHE A 1 487 ? 194.095 140.528 146.907 1.00 54.98  ? 487 PHE A C   1 
ATOM   2020 O O   . PHE A 1 487 ? 194.093 140.267 148.116 1.00 52.53  ? 487 PHE A O   1 
ATOM   2021 C CB  . PHE A 1 487 ? 193.706 138.801 145.164 1.00 45.17  ? 487 PHE A CB  1 
ATOM   2022 C CG  . PHE A 1 487 ? 192.825 138.206 144.114 1.00 46.84  ? 487 PHE A CG  1 
ATOM   2023 C CD1 . PHE A 1 487 ? 191.456 138.154 144.273 1.00 45.70  ? 487 PHE A CD1 1 
ATOM   2024 C CD2 . PHE A 1 487 ? 193.381 137.684 142.962 1.00 51.97  ? 487 PHE A CD2 1 
ATOM   2025 C CE1 . PHE A 1 487 ? 190.661 137.603 143.296 1.00 46.68  ? 487 PHE A CE1 1 
ATOM   2026 C CE2 . PHE A 1 487 ? 192.591 137.133 141.984 1.00 46.21  ? 487 PHE A CE2 1 
ATOM   2027 C CZ  . PHE A 1 487 ? 191.232 137.094 142.151 1.00 41.93  ? 487 PHE A CZ  1 
ATOM   2028 N N   . PHE A 1 488 ? 195.002 141.331 146.349 1.00 56.02  ? 488 PHE A N   1 
ATOM   2029 C CA  . PHE A 1 488 ? 196.070 141.913 147.156 1.00 55.85  ? 488 PHE A CA  1 
ATOM   2030 C C   . PHE A 1 488 ? 195.514 142.841 148.228 1.00 60.68  ? 488 PHE A C   1 
ATOM   2031 O O   . PHE A 1 488 ? 195.924 142.775 149.394 1.00 67.53  ? 488 PHE A O   1 
ATOM   2032 C CB  . PHE A 1 488 ? 197.063 142.654 146.264 1.00 50.62  ? 488 PHE A CB  1 
ATOM   2033 C CG  . PHE A 1 488 ? 198.031 141.752 145.560 1.00 56.94  ? 488 PHE A CG  1 
ATOM   2034 C CD1 . PHE A 1 488 ? 199.144 141.265 146.220 1.00 64.75  ? 488 PHE A CD1 1 
ATOM   2035 C CD2 . PHE A 1 488 ? 197.829 141.390 144.241 1.00 64.69  ? 488 PHE A CD2 1 
ATOM   2036 C CE1 . PHE A 1 488 ? 200.037 140.432 145.577 1.00 78.11  ? 488 PHE A CE1 1 
ATOM   2037 C CE2 . PHE A 1 488 ? 198.718 140.558 143.592 1.00 71.63  ? 488 PHE A CE2 1 
ATOM   2038 C CZ  . PHE A 1 488 ? 199.824 140.079 144.261 1.00 81.90  ? 488 PHE A CZ  1 
ATOM   2039 N N   . MET A 1 489 ? 194.565 143.702 147.858 1.00 51.86  ? 489 MET A N   1 
ATOM   2040 C CA  . MET A 1 489 ? 193.983 144.619 148.829 1.00 53.76  ? 489 MET A CA  1 
ATOM   2041 C C   . MET A 1 489 ? 193.258 143.863 149.935 1.00 61.22  ? 489 MET A C   1 
ATOM   2042 O O   . MET A 1 489 ? 193.408 144.182 151.120 1.00 62.51  ? 489 MET A O   1 
ATOM   2043 C CB  . MET A 1 489 ? 193.030 145.582 148.129 1.00 54.17  ? 489 MET A CB  1 
ATOM   2044 C CG  . MET A 1 489 ? 192.260 146.458 149.086 1.00 63.80  ? 489 MET A CG  1 
ATOM   2045 S SD  . MET A 1 489 ? 190.825 147.198 148.308 1.00 72.66  ? 489 MET A SD  1 
ATOM   2046 C CE  . MET A 1 489 ? 189.936 145.743 147.768 1.00 62.32  ? 489 MET A CE  1 
ATOM   2047 N N   . VAL A 1 490 ? 192.468 142.852 149.567 1.00 63.67  ? 490 VAL A N   1 
ATOM   2048 C CA  . VAL A 1 490 ? 191.708 142.109 150.566 1.00 59.29  ? 490 VAL A CA  1 
ATOM   2049 C C   . VAL A 1 490 ? 192.640 141.352 151.502 1.00 63.81  ? 490 VAL A C   1 
ATOM   2050 O O   . VAL A 1 490 ? 192.435 141.342 152.721 1.00 70.00  ? 490 VAL A O   1 
ATOM   2051 C CB  . VAL A 1 490 ? 190.699 141.169 149.885 1.00 57.30  ? 490 VAL A CB  1 
ATOM   2052 C CG1 . VAL A 1 490 ? 190.092 140.220 150.900 1.00 56.56  ? 490 VAL A CG1 1 
ATOM   2053 C CG2 . VAL A 1 490 ? 189.610 141.976 149.206 1.00 58.36  ? 490 VAL A CG2 1 
ATOM   2054 N N   . THR A 1 491 ? 193.680 140.708 150.962 1.00 59.97  ? 491 THR A N   1 
ATOM   2055 C CA  . THR A 1 491 ? 194.575 139.954 151.833 1.00 61.29  ? 491 THR A CA  1 
ATOM   2056 C C   . THR A 1 491 ? 195.382 140.874 152.737 1.00 67.22  ? 491 THR A C   1 
ATOM   2057 O O   . THR A 1 491 ? 195.637 140.525 153.894 1.00 71.62  ? 491 THR A O   1 
ATOM   2058 C CB  . THR A 1 491 ? 195.500 139.041 151.020 1.00 62.32  ? 491 THR A CB  1 
ATOM   2059 O OG1 . THR A 1 491 ? 196.232 138.194 151.914 1.00 68.15  ? 491 THR A OG1 1 
ATOM   2060 C CG2 . THR A 1 491 ? 196.484 139.835 150.189 1.00 59.00  ? 491 THR A CG2 1 
ATOM   2061 N N   . PHE A 1 492 ? 195.764 142.061 152.258 1.00 65.52  ? 492 PHE A N   1 
ATOM   2062 C CA  . PHE A 1 492 ? 196.496 142.976 153.126 1.00 64.11  ? 492 PHE A CA  1 
ATOM   2063 C C   . PHE A 1 492 ? 195.592 143.566 154.202 1.00 73.92  ? 492 PHE A C   1 
ATOM   2064 O O   . PHE A 1 492 ? 196.021 143.744 155.347 1.00 83.85  ? 492 PHE A O   1 
ATOM   2065 C CB  . PHE A 1 492 ? 197.164 144.065 152.295 1.00 60.04  ? 492 PHE A CB  1 
ATOM   2066 C CG  . PHE A 1 492 ? 198.488 143.648 151.734 1.00 66.98  ? 492 PHE A CG  1 
ATOM   2067 C CD1 . PHE A 1 492 ? 199.372 142.917 152.507 1.00 69.90  ? 492 PHE A CD1 1 
ATOM   2068 C CD2 . PHE A 1 492 ? 198.841 143.958 150.435 1.00 67.59  ? 492 PHE A CD2 1 
ATOM   2069 C CE1 . PHE A 1 492 ? 200.589 142.517 152.002 1.00 69.05  ? 492 PHE A CE1 1 
ATOM   2070 C CE2 . PHE A 1 492 ? 200.059 143.558 149.925 1.00 67.35  ? 492 PHE A CE2 1 
ATOM   2071 C CZ  . PHE A 1 492 ? 200.933 142.838 150.710 1.00 69.49  ? 492 PHE A CZ  1 
ATOM   2072 N N   . ALA A 1 493 ? 194.332 143.855 153.866 1.00 72.76  ? 493 ALA A N   1 
ATOM   2073 C CA  . ALA A 1 493 ? 193.389 144.298 154.887 1.00 70.64  ? 493 ALA A CA  1 
ATOM   2074 C C   . ALA A 1 493 ? 193.155 143.208 155.927 1.00 78.62  ? 493 ALA A C   1 
ATOM   2075 O O   . ALA A 1 493 ? 193.082 143.490 157.130 1.00 84.58  ? 493 ALA A O   1 
ATOM   2076 C CB  . ALA A 1 493 ? 192.070 144.716 154.240 1.00 67.38  ? 493 ALA A CB  1 
ATOM   2077 N N   . ALA A 1 494 ? 193.037 141.955 155.481 1.00 74.75  ? 494 ALA A N   1 
ATOM   2078 C CA  . ALA A 1 494 ? 192.850 140.849 156.414 1.00 73.08  ? 494 ALA A CA  1 
ATOM   2079 C C   . ALA A 1 494 ? 194.064 140.676 157.316 1.00 83.47  ? 494 ALA A C   1 
ATOM   2080 O O   . ALA A 1 494 ? 193.920 140.436 158.520 1.00 90.59  ? 494 ALA A O   1 
ATOM   2081 C CB  . ALA A 1 494 ? 192.561 139.560 155.647 1.00 66.24  ? 494 ALA A CB  1 
ATOM   2082 N N   . LEU A 1 495 ? 195.269 140.789 156.753 1.00 84.38  ? 495 LEU A N   1 
ATOM   2083 C CA  . LEU A 1 495 ? 196.476 140.692 157.567 1.00 88.51  ? 495 LEU A CA  1 
ATOM   2084 C C   . LEU A 1 495 ? 196.552 141.828 158.577 1.00 93.12  ? 495 LEU A C   1 
ATOM   2085 O O   . LEU A 1 495 ? 196.922 141.612 159.737 1.00 101.57 ? 495 LEU A O   1 
ATOM   2086 C CB  . LEU A 1 495 ? 197.717 140.679 156.677 1.00 86.65  ? 495 LEU A CB  1 
ATOM   2087 C CG  . LEU A 1 495 ? 197.960 139.374 155.921 1.00 83.64  ? 495 LEU A CG  1 
ATOM   2088 C CD1 . LEU A 1 495 ? 199.252 139.446 155.129 1.00 85.95  ? 495 LEU A CD1 1 
ATOM   2089 C CD2 . LEU A 1 495 ? 197.983 138.204 156.889 1.00 86.29  ? 495 LEU A CD2 1 
ATOM   2090 N N   . TYR A 1 496 ? 196.206 143.047 158.157 1.00 88.04  ? 496 TYR A N   1 
ATOM   2091 C CA  . TYR A 1 496 ? 196.209 144.174 159.082 1.00 90.51  ? 496 TYR A CA  1 
ATOM   2092 C C   . TYR A 1 496 ? 195.228 143.945 160.224 1.00 98.57  ? 496 TYR A C   1 
ATOM   2093 O O   . TYR A 1 496 ? 195.556 144.173 161.393 1.00 105.90 ? 496 TYR A O   1 
ATOM   2094 C CB  . TYR A 1 496 ? 195.876 145.468 158.340 1.00 89.30  ? 496 TYR A CB  1 
ATOM   2095 C CG  . TYR A 1 496 ? 195.714 146.665 159.251 1.00 96.91  ? 496 TYR A CG  1 
ATOM   2096 C CD1 . TYR A 1 496 ? 194.457 147.082 159.665 1.00 98.78  ? 496 TYR A CD1 1 
ATOM   2097 C CD2 . TYR A 1 496 ? 196.818 147.373 159.701 1.00 102.09 ? 496 TYR A CD2 1 
ATOM   2098 C CE1 . TYR A 1 496 ? 194.306 148.170 160.500 1.00 105.04 ? 496 TYR A CE1 1 
ATOM   2099 C CE2 . TYR A 1 496 ? 196.676 148.463 160.536 1.00 104.90 ? 496 TYR A CE2 1 
ATOM   2100 C CZ  . TYR A 1 496 ? 195.418 148.858 160.931 1.00 110.76 ? 496 TYR A CZ  1 
ATOM   2101 O OH  . TYR A 1 496 ? 195.272 149.944 161.762 1.00 120.09 ? 496 TYR A OH  1 
ATOM   2102 N N   . SER A 1 497 ? 194.016 143.484 159.903 1.00 94.49  ? 497 SER A N   1 
ATOM   2103 C CA  . SER A 1 497 ? 193.024 143.241 160.946 1.00 96.21  ? 497 SER A CA  1 
ATOM   2104 C C   . SER A 1 497 ? 193.470 142.132 161.891 1.00 100.93 ? 497 SER A C   1 
ATOM   2105 O O   . SER A 1 497 ? 193.334 142.256 163.114 1.00 108.23 ? 497 SER A O   1 
ATOM   2106 C CB  . SER A 1 497 ? 191.673 142.901 160.318 1.00 96.22  ? 497 SER A CB  1 
ATOM   2107 O OG  . SER A 1 497 ? 191.167 143.998 159.579 1.00 97.63  ? 497 SER A OG  1 
ATOM   2108 N N   . THR A 1 498 ? 194.014 141.042 161.344 1.00 99.00  ? 498 THR A N   1 
ATOM   2109 C CA  . THR A 1 498 ? 194.452 139.933 162.183 1.00 103.24 ? 498 THR A CA  1 
ATOM   2110 C C   . THR A 1 498 ? 195.609 140.333 163.088 1.00 110.38 ? 498 THR A C   1 
ATOM   2111 O O   . THR A 1 498 ? 195.646 139.930 164.257 1.00 119.23 ? 498 THR A O   1 
ATOM   2112 C CB  . THR A 1 498 ? 194.849 138.740 161.314 1.00 107.31 ? 498 THR A CB  1 
ATOM   2113 O OG1 . THR A 1 498 ? 193.794 138.450 160.389 1.00 109.32 ? 498 THR A OG1 1 
ATOM   2114 C CG2 . THR A 1 498 ? 195.103 137.514 162.177 1.00 104.85 ? 498 THR A CG2 1 
ATOM   2115 N N   . HIS A 1 499 ? 196.558 141.118 162.576 1.00 110.03 ? 499 HIS A N   1 
ATOM   2116 C CA  . HIS A 1 499 ? 197.674 141.560 163.403 1.00 115.05 ? 499 HIS A CA  1 
ATOM   2117 C C   . HIS A 1 499 ? 197.235 142.582 164.444 1.00 117.86 ? 499 HIS A C   1 
ATOM   2118 O O   . HIS A 1 499 ? 197.752 142.586 165.566 1.00 124.03 ? 499 HIS A O   1 
ATOM   2119 C CB  . HIS A 1 499 ? 198.786 142.128 162.522 1.00 112.86 ? 499 HIS A CB  1 
ATOM   2120 C CG  . HIS A 1 499 ? 199.639 141.079 161.880 1.00 117.87 ? 499 HIS A CG  1 
ATOM   2121 N ND1 . HIS A 1 499 ? 200.916 140.793 162.311 1.00 121.36 ? 499 HIS A ND1 1 
ATOM   2122 C CD2 . HIS A 1 499 ? 199.394 140.241 160.845 1.00 116.50 ? 499 HIS A CD2 1 
ATOM   2123 C CE1 . HIS A 1 499 ? 201.424 139.827 161.566 1.00 120.93 ? 499 HIS A CE1 1 
ATOM   2124 N NE2 . HIS A 1 499 ? 200.521 139.474 160.670 1.00 121.85 ? 499 HIS A NE2 1 
ATOM   2125 N N   . LYS A 1 500 ? 196.285 143.454 164.099 1.00 112.26 ? 500 LYS A N   1 
ATOM   2126 C CA  . LYS A 1 500 ? 195.789 144.424 165.066 1.00 112.77 ? 500 LYS A CA  1 
ATOM   2127 C C   . LYS A 1 500 ? 194.911 143.776 166.126 1.00 117.46 ? 500 LYS A C   1 
ATOM   2128 O O   . LYS A 1 500 ? 194.762 144.336 167.217 1.00 120.74 ? 500 LYS A O   1 
ATOM   2129 C CB  . LYS A 1 500 ? 195.020 145.533 164.347 1.00 108.53 ? 500 LYS A CB  1 
ATOM   2130 C CG  . LYS A 1 500 ? 194.934 146.833 165.123 1.00 110.04 ? 500 LYS A CG  1 
ATOM   2131 C CD  . LYS A 1 500 ? 194.214 147.903 164.323 1.00 107.43 ? 500 LYS A CD  1 
ATOM   2132 C CE  . LYS A 1 500 ? 194.318 149.260 164.999 1.00 108.00 ? 500 LYS A CE  1 
ATOM   2133 N NZ  . LYS A 1 500 ? 193.784 149.231 166.387 1.00 114.24 ? 500 LYS A NZ  1 
ATOM   2134 N N   . GLU A 1 501 ? 194.322 142.617 165.826 1.00 115.82 ? 501 GLU A N   1 
ATOM   2135 C CA  . GLU A 1 501 ? 193.579 141.883 166.845 1.00 120.63 ? 501 GLU A CA  1 
ATOM   2136 C C   . GLU A 1 501 ? 194.493 141.455 167.987 1.00 124.86 ? 501 GLU A C   1 
ATOM   2137 O O   . GLU A 1 501 ? 194.114 141.536 169.161 1.00 129.00 ? 501 GLU A O   1 
ATOM   2138 C CB  . GLU A 1 501 ? 192.891 140.670 166.220 1.00 122.33 ? 501 GLU A CB  1 
ATOM   2139 C CG  . GLU A 1 501 ? 192.132 139.797 167.209 1.00 124.09 ? 501 GLU A CG  1 
ATOM   2140 C CD  . GLU A 1 501 ? 190.903 140.482 167.779 1.00 124.24 ? 501 GLU A CD  1 
ATOM   2141 O OE1 . GLU A 1 501 ? 190.422 141.458 167.166 1.00 124.14 ? 501 GLU A OE1 1 
ATOM   2142 O OE2 . GLU A 1 501 ? 190.417 140.040 168.841 1.00 119.95 ? 501 GLU A OE2 1 
ATOM   2143 N N   . ARG A 1 502 ? 195.700 140.998 167.662 1.00 124.61 ? 502 ARG A N   1 
ATOM   2144 C CA  . ARG A 1 502 ? 196.683 140.618 168.667 1.00 127.66 ? 502 ARG A CA  1 
ATOM   2145 C C   . ARG A 1 502 ? 197.575 141.776 169.096 1.00 127.60 ? 502 ARG A C   1 
ATOM   2146 O O   . ARG A 1 502 ? 198.387 141.603 170.010 1.00 130.53 ? 502 ARG A O   1 
ATOM   2147 C CB  . ARG A 1 502 ? 197.560 139.475 168.145 1.00 128.59 ? 502 ARG A CB  1 
ATOM   2148 C CG  . ARG A 1 502 ? 196.786 138.281 167.617 1.00 131.31 ? 502 ARG A CG  1 
ATOM   2149 C CD  . ARG A 1 502 ? 197.731 137.206 167.112 1.00 131.25 ? 502 ARG A CD  1 
ATOM   2150 N NE  . ARG A 1 502 ? 198.713 137.744 166.179 1.00 132.89 ? 502 ARG A NE  1 
ATOM   2151 C CZ  . ARG A 1 502 ? 199.669 137.030 165.601 1.00 132.75 ? 502 ARG A CZ  1 
ATOM   2152 N NH1 . ARG A 1 502 ? 199.798 135.734 165.831 1.00 128.48 ? 502 ARG A NH1 1 
ATOM   2153 N NH2 . ARG A 1 502 ? 200.517 137.632 164.772 1.00 130.79 ? 502 ARG A NH2 1 
ATOM   2154 N N   . GLY A 1 503 ? 197.444 142.941 168.467 1.00 125.16 ? 503 GLY A N   1 
ATOM   2155 C CA  . GLY A 1 503 ? 198.305 144.064 168.785 1.00 124.72 ? 503 GLY A CA  1 
ATOM   2156 C C   . GLY A 1 503 ? 199.757 143.862 168.416 1.00 127.13 ? 503 GLY A C   1 
ATOM   2157 O O   . GLY A 1 503 ? 200.644 144.298 169.156 1.00 125.47 ? 503 GLY A O   1 
ATOM   2158 N N   . HIS A 1 504 ? 200.024 143.213 167.287 1.00 128.28 ? 504 HIS A N   1 
ATOM   2159 C CA  . HIS A 1 504 ? 201.395 142.945 166.879 1.00 129.70 ? 504 HIS A CA  1 
ATOM   2160 C C   . HIS A 1 504 ? 202.065 144.217 166.369 1.00 129.59 ? 504 HIS A C   1 
ATOM   2161 O O   . HIS A 1 504 ? 201.410 145.223 166.086 1.00 127.89 ? 504 HIS A O   1 
ATOM   2162 C CB  . HIS A 1 504 ? 201.428 141.863 165.799 1.00 128.98 ? 504 HIS A CB  1 
ATOM   2163 C CG  . HIS A 1 504 ? 202.746 141.163 165.686 1.00 131.33 ? 504 HIS A CG  1 
ATOM   2164 N ND1 . HIS A 1 504 ? 203.744 141.585 164.833 1.00 132.93 ? 504 HIS A ND1 1 
ATOM   2165 C CD2 . HIS A 1 504 ? 203.231 140.068 166.318 1.00 131.07 ? 504 HIS A CD2 1 
ATOM   2166 C CE1 . HIS A 1 504 ? 204.786 140.781 164.946 1.00 132.97 ? 504 HIS A CE1 1 
ATOM   2167 N NE2 . HIS A 1 504 ? 204.500 139.852 165.840 1.00 135.61 ? 504 HIS A NE2 1 
ATOM   2168 N N   . SER A 1 505 ? 203.394 144.166 166.266 1.00 129.95 ? 505 SER A N   1 
ATOM   2169 C CA  . SER A 1 505 ? 204.154 145.317 165.794 1.00 129.85 ? 505 SER A CA  1 
ATOM   2170 C C   . SER A 1 505 ? 204.147 145.445 164.276 1.00 129.99 ? 505 SER A C   1 
ATOM   2171 O O   . SER A 1 505 ? 204.537 146.494 163.755 1.00 127.74 ? 505 SER A O   1 
ATOM   2172 C CB  . SER A 1 505 ? 205.595 145.236 166.301 1.00 126.23 ? 505 SER A CB  1 
ATOM   2173 O OG  . SER A 1 505 ? 206.214 144.028 165.891 1.00 125.91 ? 505 SER A OG  1 
ATOM   2174 N N   . ASP A 1 506 ? 203.717 144.407 163.557 1.00 130.16 ? 506 ASP A N   1 
ATOM   2175 C CA  . ASP A 1 506 ? 203.735 144.441 162.099 1.00 124.84 ? 506 ASP A CA  1 
ATOM   2176 C C   . ASP A 1 506 ? 202.539 145.167 161.501 1.00 121.53 ? 506 ASP A C   1 
ATOM   2177 O O   . ASP A 1 506 ? 202.539 145.413 160.290 1.00 116.72 ? 506 ASP A O   1 
ATOM   2178 C CB  . ASP A 1 506 ? 203.792 143.018 161.538 1.00 122.80 ? 506 ASP A CB  1 
ATOM   2179 C CG  . ASP A 1 506 ? 205.101 142.322 161.848 1.00 126.20 ? 506 ASP A CG  1 
ATOM   2180 O OD1 . ASP A 1 506 ? 206.119 143.022 162.032 1.00 124.07 ? 506 ASP A OD1 1 
ATOM   2181 O OD2 . ASP A 1 506 ? 205.112 141.074 161.902 1.00 126.39 ? 506 ASP A OD2 1 
ATOM   2182 N N   . THR A 1 507 ? 201.541 145.528 162.314 1.00 122.86 ? 507 THR A N   1 
ATOM   2183 C CA  . THR A 1 507 ? 200.310 146.111 161.785 1.00 119.81 ? 507 THR A CA  1 
ATOM   2184 C C   . THR A 1 507 ? 200.606 147.279 160.855 1.00 115.75 ? 507 THR A C   1 
ATOM   2185 O O   . THR A 1 507 ? 200.127 147.322 159.715 1.00 110.07 ? 507 THR A O   1 
ATOM   2186 C CB  . THR A 1 507 ? 199.412 146.570 162.934 1.00 120.15 ? 507 THR A CB  1 
ATOM   2187 O OG1 . THR A 1 507 ? 200.069 147.614 163.665 1.00 121.32 ? 507 THR A OG1 1 
ATOM   2188 C CG2 . THR A 1 507 ? 199.121 145.420 163.872 1.00 118.20 ? 507 THR A CG2 1 
ATOM   2189 N N   . MET A 1 508 ? 201.435 148.217 161.315 1.00 116.79 ? 508 MET A N   1 
ATOM   2190 C CA  . MET A 1 508 ? 201.739 149.394 160.513 1.00 115.21 ? 508 MET A CA  1 
ATOM   2191 C C   . MET A 1 508 ? 202.387 149.002 159.191 1.00 112.10 ? 508 MET A C   1 
ATOM   2192 O O   . MET A 1 508 ? 202.025 149.526 158.131 1.00 108.69 ? 508 MET A O   1 
ATOM   2193 C CB  . MET A 1 508 ? 202.638 150.344 161.303 1.00 116.71 ? 508 MET A CB  1 
ATOM   2194 C CG  . MET A 1 508 ? 202.232 151.805 161.206 1.00 124.98 ? 508 MET A CG  1 
ATOM   2195 S SD  . MET A 1 508 ? 200.537 152.088 161.751 1.00 136.62 ? 508 MET A SD  1 
ATOM   2196 C CE  . MET A 1 508 ? 200.399 153.859 161.527 1.00 124.14 ? 508 MET A CE  1 
ATOM   2197 N N   . VAL A 1 509 ? 203.316 148.044 159.227 1.00 109.99 ? 509 VAL A N   1 
ATOM   2198 C CA  . VAL A 1 509 ? 204.066 147.674 158.030 1.00 105.17 ? 509 VAL A CA  1 
ATOM   2199 C C   . VAL A 1 509 ? 203.120 147.020 157.033 1.00 102.96 ? 509 VAL A C   1 
ATOM   2200 O O   . VAL A 1 509 ? 203.451 146.870 155.851 1.00 98.55  ? 509 VAL A O   1 
ATOM   2201 C CB  . VAL A 1 509 ? 205.257 146.753 158.362 1.00 104.91 ? 509 VAL A CB  1 
ATOM   2202 C CG1 . VAL A 1 509 ? 205.811 147.070 159.744 1.00 106.29 ? 509 VAL A CG1 1 
ATOM   2203 C CG2 . VAL A 1 509 ? 204.870 145.284 158.242 1.00 107.09 ? 509 VAL A CG2 1 
ATOM   2204 N N   . PHE A 1 510 ? 201.933 146.633 157.497 1.00 104.97 ? 510 PHE A N   1 
ATOM   2205 C CA  . PHE A 1 510 ? 200.873 146.183 156.607 1.00 100.83 ? 510 PHE A CA  1 
ATOM   2206 C C   . PHE A 1 510 ? 199.920 147.305 156.227 1.00 96.04  ? 510 PHE A C   1 
ATOM   2207 O O   . PHE A 1 510 ? 199.511 147.393 155.063 1.00 92.06  ? 510 PHE A O   1 
ATOM   2208 C CB  . PHE A 1 510 ? 200.086 145.039 157.251 1.00 98.03  ? 510 PHE A CB  1 
ATOM   2209 C CG  . PHE A 1 510 ? 200.836 143.741 157.291 1.00 98.94  ? 510 PHE A CG  1 
ATOM   2210 C CD1 . PHE A 1 510 ? 201.798 143.454 156.339 1.00 99.02  ? 510 PHE A CD1 1 
ATOM   2211 C CD2 . PHE A 1 510 ? 200.581 142.809 158.280 1.00 105.84 ? 510 PHE A CD2 1 
ATOM   2212 C CE1 . PHE A 1 510 ? 202.490 142.261 156.372 1.00 98.31  ? 510 PHE A CE1 1 
ATOM   2213 C CE2 . PHE A 1 510 ? 201.271 141.614 158.318 1.00 108.43 ? 510 PHE A CE2 1 
ATOM   2214 C CZ  . PHE A 1 510 ? 202.227 141.341 157.363 1.00 101.56 ? 510 PHE A CZ  1 
ATOM   2215 N N   . PHE A 1 511 ? 199.592 148.181 157.182 1.00 101.18 ? 511 PHE A N   1 
ATOM   2216 C CA  . PHE A 1 511 ? 198.629 149.252 156.948 1.00 100.10 ? 511 PHE A CA  1 
ATOM   2217 C C   . PHE A 1 511 ? 198.972 150.036 155.689 1.00 94.26  ? 511 PHE A C   1 
ATOM   2218 O O   . PHE A 1 511 ? 198.193 150.069 154.728 1.00 86.89  ? 511 PHE A O   1 
ATOM   2219 C CB  . PHE A 1 511 ? 198.582 150.176 158.168 1.00 103.85 ? 511 PHE A CB  1 
ATOM   2220 C CG  . PHE A 1 511 ? 197.686 151.371 157.996 1.00 106.35 ? 511 PHE A CG  1 
ATOM   2221 C CD1 . PHE A 1 511 ? 196.332 151.283 158.270 1.00 99.44  ? 511 PHE A CD1 1 
ATOM   2222 C CD2 . PHE A 1 511 ? 198.202 152.586 157.574 1.00 108.38 ? 511 PHE A CD2 1 
ATOM   2223 C CE1 . PHE A 1 511 ? 195.509 152.381 158.117 1.00 101.60 ? 511 PHE A CE1 1 
ATOM   2224 C CE2 . PHE A 1 511 ? 197.384 153.687 157.418 1.00 102.64 ? 511 PHE A CE2 1 
ATOM   2225 C CZ  . PHE A 1 511 ? 196.036 153.585 157.691 1.00 103.59 ? 511 PHE A CZ  1 
ATOM   2226 N N   . TYR A 1 512 ? 200.160 150.645 155.670 1.00 97.64  ? 512 TYR A N   1 
ATOM   2227 C CA  . TYR A 1 512 ? 200.593 151.403 154.502 1.00 97.32  ? 512 TYR A CA  1 
ATOM   2228 C C   . TYR A 1 512 ? 200.478 150.563 153.240 1.00 86.08  ? 512 TYR A C   1 
ATOM   2229 O O   . TYR A 1 512 ? 199.966 151.029 152.215 1.00 79.59  ? 512 TYR A O   1 
ATOM   2230 C CB  . TYR A 1 512 ? 202.030 151.892 154.692 1.00 104.84 ? 512 TYR A CB  1 
ATOM   2231 C CG  . TYR A 1 512 ? 202.250 152.685 155.958 1.00 109.82 ? 512 TYR A CG  1 
ATOM   2232 C CD1 . TYR A 1 512 ? 201.608 153.899 156.161 1.00 112.51 ? 512 TYR A CD1 1 
ATOM   2233 C CD2 . TYR A 1 512 ? 203.111 152.227 156.944 1.00 111.27 ? 512 TYR A CD2 1 
ATOM   2234 C CE1 . TYR A 1 512 ? 201.809 154.629 157.316 1.00 120.05 ? 512 TYR A CE1 1 
ATOM   2235 C CE2 . TYR A 1 512 ? 203.321 152.949 158.101 1.00 118.40 ? 512 TYR A CE2 1 
ATOM   2236 C CZ  . TYR A 1 512 ? 202.667 154.149 158.282 1.00 125.10 ? 512 TYR A CZ  1 
ATOM   2237 O OH  . TYR A 1 512 ? 202.874 154.872 159.435 1.00 129.21 ? 512 TYR A OH  1 
ATOM   2238 N N   . LEU A 1 513 ? 200.915 149.301 153.313 1.00 87.08  ? 513 LEU A N   1 
ATOM   2239 C CA  . LEU A 1 513 ? 200.808 148.416 152.159 1.00 84.28  ? 513 LEU A CA  1 
ATOM   2240 C C   . LEU A 1 513 ? 199.377 148.378 151.647 1.00 81.27  ? 513 LEU A C   1 
ATOM   2241 O O   . LEU A 1 513 ? 199.117 148.673 150.473 1.00 78.97  ? 513 LEU A O   1 
ATOM   2242 C CB  . LEU A 1 513 ? 201.286 147.011 152.525 1.00 79.68  ? 513 LEU A CB  1 
ATOM   2243 C CG  . LEU A 1 513 ? 202.699 146.632 152.084 1.00 82.57  ? 513 LEU A CG  1 
ATOM   2244 C CD1 . LEU A 1 513 ? 203.723 147.597 152.656 1.00 90.88  ? 513 LEU A CD1 1 
ATOM   2245 C CD2 . LEU A 1 513 ? 203.017 145.205 152.494 1.00 79.86  ? 513 LEU A CD2 1 
ATOM   2246 N N   . TRP A 1 514 ? 198.426 148.095 152.541 1.00 80.59  ? 514 TRP A N   1 
ATOM   2247 C CA  . TRP A 1 514 ? 197.026 148.097 152.137 1.00 72.75  ? 514 TRP A CA  1 
ATOM   2248 C C   . TRP A 1 514 ? 196.648 149.442 151.539 1.00 72.62  ? 514 TRP A C   1 
ATOM   2249 O O   . TRP A 1 514 ? 196.053 149.500 150.454 1.00 73.92  ? 514 TRP A O   1 
ATOM   2250 C CB  . TRP A 1 514 ? 196.129 147.762 153.327 1.00 71.40  ? 514 TRP A CB  1 
ATOM   2251 C CG  . TRP A 1 514 ? 194.677 147.965 153.045 1.00 69.80  ? 514 TRP A CG  1 
ATOM   2252 C CD1 . TRP A 1 514 ? 193.870 147.164 152.297 1.00 70.10  ? 514 TRP A CD1 1 
ATOM   2253 C CD2 . TRP A 1 514 ? 193.855 149.042 153.508 1.00 71.44  ? 514 TRP A CD2 1 
ATOM   2254 N NE1 . TRP A 1 514 ? 192.597 147.674 152.262 1.00 68.43  ? 514 TRP A NE1 1 
ATOM   2255 C CE2 . TRP A 1 514 ? 192.562 148.827 152.999 1.00 68.74  ? 514 TRP A CE2 1 
ATOM   2256 C CE3 . TRP A 1 514 ? 194.088 150.167 154.303 1.00 76.78  ? 514 TRP A CE3 1 
ATOM   2257 C CZ2 . TRP A 1 514 ? 191.505 149.696 153.258 1.00 63.32  ? 514 TRP A CZ2 1 
ATOM   2258 C CZ3 . TRP A 1 514 ? 193.037 151.025 154.561 1.00 76.18  ? 514 TRP A CZ3 1 
ATOM   2259 C CH2 . TRP A 1 514 ? 191.762 150.786 154.039 1.00 68.26  ? 514 TRP A CH2 1 
ATOM   2260 N N   . ILE A 1 515 ? 197.057 150.533 152.194 1.00 70.77  ? 515 ILE A N   1 
ATOM   2261 C CA  . ILE A 1 515 ? 196.758 151.866 151.678 1.00 73.62  ? 515 ILE A CA  1 
ATOM   2262 C C   . ILE A 1 515 ? 197.258 151.988 150.249 1.00 71.40  ? 515 ILE A C   1 
ATOM   2263 O O   . ILE A 1 515 ? 196.524 152.416 149.349 1.00 64.94  ? 515 ILE A O   1 
ATOM   2264 C CB  . ILE A 1 515 ? 197.376 152.947 152.582 1.00 77.05  ? 515 ILE A CB  1 
ATOM   2265 C CG1 . ILE A 1 515 ? 196.656 153.000 153.930 1.00 83.15  ? 515 ILE A CG1 1 
ATOM   2266 C CG2 . ILE A 1 515 ? 197.327 154.303 151.896 1.00 64.21  ? 515 ILE A CG2 1 
ATOM   2267 C CD1 . ILE A 1 515 ? 195.271 153.595 153.855 1.00 75.38  ? 515 ILE A CD1 1 
ATOM   2268 N N   . VAL A 1 516 ? 198.496 151.546 150.009 1.00 74.69  ? 516 VAL A N   1 
ATOM   2269 C CA  . VAL A 1 516 ? 199.050 151.619 148.661 1.00 67.74  ? 516 VAL A CA  1 
ATOM   2270 C C   . VAL A 1 516 ? 198.142 150.883 147.691 1.00 61.60  ? 516 VAL A C   1 
ATOM   2271 O O   . VAL A 1 516 ? 197.704 151.438 146.676 1.00 61.44  ? 516 VAL A O   1 
ATOM   2272 C CB  . VAL A 1 516 ? 200.482 151.054 148.635 1.00 56.64  ? 516 VAL A CB  1 
ATOM   2273 C CG1 . VAL A 1 516 ? 200.974 150.937 147.206 1.00 52.20  ? 516 VAL A CG1 1 
ATOM   2274 C CG2 . VAL A 1 516 ? 201.411 151.935 149.448 1.00 62.37  ? 516 VAL A CG2 1 
ATOM   2275 N N   . PHE A 1 517 ? 197.780 149.646 148.030 1.00 59.43  ? 517 PHE A N   1 
ATOM   2276 C CA  . PHE A 1 517 ? 196.900 148.900 147.145 1.00 57.30  ? 517 PHE A CA  1 
ATOM   2277 C C   . PHE A 1 517 ? 195.515 149.521 147.103 1.00 57.97  ? 517 PHE A C   1 
ATOM   2278 O O   . PHE A 1 517 ? 194.883 149.535 146.039 1.00 57.31  ? 517 PHE A O   1 
ATOM   2279 C CB  . PHE A 1 517 ? 196.855 147.436 147.563 1.00 57.45  ? 517 PHE A CB  1 
ATOM   2280 C CG  . PHE A 1 517 ? 198.087 146.677 147.176 1.00 59.61  ? 517 PHE A CG  1 
ATOM   2281 C CD1 . PHE A 1 517 ? 198.164 146.037 145.953 1.00 60.41  ? 517 PHE A CD1 1 
ATOM   2282 C CD2 . PHE A 1 517 ? 199.183 146.635 148.017 1.00 60.01  ? 517 PHE A CD2 1 
ATOM   2283 C CE1 . PHE A 1 517 ? 199.301 145.352 145.587 1.00 65.98  ? 517 PHE A CE1 1 
ATOM   2284 C CE2 . PHE A 1 517 ? 200.324 145.954 147.655 1.00 57.90  ? 517 PHE A CE2 1 
ATOM   2285 C CZ  . PHE A 1 517 ? 200.382 145.309 146.440 1.00 61.60  ? 517 PHE A CZ  1 
ATOM   2286 N N   . TYR A 1 518 ? 195.056 150.091 148.223 1.00 60.25  ? 518 TYR A N   1 
ATOM   2287 C CA  . TYR A 1 518 ? 193.795 150.822 148.203 1.00 54.62  ? 518 TYR A CA  1 
ATOM   2288 C C   . TYR A 1 518 ? 193.817 151.882 147.116 1.00 54.16  ? 518 TYR A C   1 
ATOM   2289 O O   . TYR A 1 518 ? 192.808 152.115 146.444 1.00 56.74  ? 518 TYR A O   1 
ATOM   2290 C CB  . TYR A 1 518 ? 193.515 151.465 149.562 1.00 57.50  ? 518 TYR A CB  1 
ATOM   2291 C CG  . TYR A 1 518 ? 192.191 152.201 149.617 1.00 57.08  ? 518 TYR A CG  1 
ATOM   2292 C CD1 . TYR A 1 518 ? 192.071 153.506 149.152 1.00 51.14  ? 518 TYR A CD1 1 
ATOM   2293 C CD2 . TYR A 1 518 ? 191.060 151.590 150.133 1.00 64.11  ? 518 TYR A CD2 1 
ATOM   2294 C CE1 . TYR A 1 518 ? 190.866 154.172 149.194 1.00 49.99  ? 518 TYR A CE1 1 
ATOM   2295 C CE2 . TYR A 1 518 ? 189.852 152.252 150.183 1.00 60.47  ? 518 TYR A CE2 1 
ATOM   2296 C CZ  . TYR A 1 518 ? 189.761 153.541 149.712 1.00 57.02  ? 518 TYR A CZ  1 
ATOM   2297 O OH  . TYR A 1 518 ? 188.557 154.201 149.762 1.00 58.19  ? 518 TYR A OH  1 
ATOM   2298 N N   . ILE A 1 519 ? 194.964 152.532 146.926 1.00 54.33  ? 519 ILE A N   1 
ATOM   2299 C CA  . ILE A 1 519 ? 195.094 153.460 145.811 1.00 52.34  ? 519 ILE A CA  1 
ATOM   2300 C C   . ILE A 1 519 ? 195.111 152.691 144.499 1.00 50.75  ? 519 ILE A C   1 
ATOM   2301 O O   . ILE A 1 519 ? 194.272 152.914 143.616 1.00 46.28  ? 519 ILE A O   1 
ATOM   2302 C CB  . ILE A 1 519 ? 196.353 154.327 145.976 1.00 52.61  ? 519 ILE A CB  1 
ATOM   2303 C CG1 . ILE A 1 519 ? 196.244 155.184 147.236 1.00 51.45  ? 519 ILE A CG1 1 
ATOM   2304 C CG2 . ILE A 1 519 ? 196.561 155.199 144.752 1.00 52.88  ? 519 ILE A CG2 1 
ATOM   2305 C CD1 . ILE A 1 519 ? 195.062 156.124 147.227 1.00 55.85  ? 519 ILE A CD1 1 
ATOM   2306 N N   . ILE A 1 520 ? 196.028 151.726 144.381 1.00 53.27  ? 520 ILE A N   1 
ATOM   2307 C CA  . ILE A 1 520 ? 196.304 151.121 143.082 1.00 48.85  ? 520 ILE A CA  1 
ATOM   2308 C C   . ILE A 1 520 ? 195.050 150.466 142.532 1.00 47.44  ? 520 ILE A C   1 
ATOM   2309 O O   . ILE A 1 520 ? 194.600 150.781 141.423 1.00 52.30  ? 520 ILE A O   1 
ATOM   2310 C CB  . ILE A 1 520 ? 197.464 150.116 143.190 1.00 48.27  ? 520 ILE A CB  1 
ATOM   2311 C CG1 . ILE A 1 520 ? 198.740 150.824 143.641 1.00 46.38  ? 520 ILE A CG1 1 
ATOM   2312 C CG2 . ILE A 1 520 ? 197.688 149.424 141.860 1.00 48.21  ? 520 ILE A CG2 1 
ATOM   2313 C CD1 . ILE A 1 520 ? 199.932 149.907 143.758 1.00 52.20  ? 520 ILE A CD1 1 
ATOM   2314 N N   . SER A 1 521 ? 194.427 149.598 143.332 1.00 45.59  ? 521 SER A N   1 
ATOM   2315 C CA  . SER A 1 521 ? 193.173 148.980 142.925 1.00 44.60  ? 521 SER A CA  1 
ATOM   2316 C C   . SER A 1 521 ? 192.167 150.040 142.509 1.00 47.60  ? 521 SER A C   1 
ATOM   2317 O O   . SER A 1 521 ? 191.620 149.993 141.400 1.00 48.22  ? 521 SER A O   1 
ATOM   2318 C CB  . SER A 1 521 ? 192.617 148.125 144.063 1.00 46.88  ? 521 SER A CB  1 
ATOM   2319 O OG  . SER A 1 521 ? 191.385 147.533 143.698 1.00 49.18  ? 521 SER A OG  1 
ATOM   2320 N N   . SER A 1 522 ? 191.971 151.053 143.359 1.00 44.46  ? 522 SER A N   1 
ATOM   2321 C CA  . SER A 1 522 ? 190.987 152.083 143.052 1.00 38.57  ? 522 SER A CA  1 
ATOM   2322 C C   . SER A 1 522 ? 191.332 152.790 141.754 1.00 43.15  ? 522 SER A C   1 
ATOM   2323 O O   . SER A 1 522 ? 190.438 153.149 140.981 1.00 45.46  ? 522 SER A O   1 
ATOM   2324 C CB  . SER A 1 522 ? 190.890 153.086 144.197 1.00 40.56  ? 522 SER A CB  1 
ATOM   2325 O OG  . SER A 1 522 ? 190.516 152.446 145.400 1.00 51.23  ? 522 SER A OG  1 
ATOM   2326 N N   . CYS A 1 523 ? 192.622 152.998 141.492 1.00 44.69  ? 523 CYS A N   1 
ATOM   2327 C CA  . CYS A 1 523 ? 193.005 153.563 140.207 1.00 41.09  ? 523 CYS A CA  1 
ATOM   2328 C C   . CYS A 1 523 ? 192.892 152.527 139.099 1.00 37.03  ? 523 CYS A C   1 
ATOM   2329 O O   . CYS A 1 523 ? 192.356 152.819 138.024 1.00 36.15  ? 523 CYS A O   1 
ATOM   2330 C CB  . CYS A 1 523 ? 194.425 154.123 140.281 1.00 49.42  ? 523 CYS A CB  1 
ATOM   2331 S SG  . CYS A 1 523 ? 194.891 155.156 138.880 1.00 86.18  ? 523 CYS A SG  1 
ATOM   2332 N N   . TYR A 1 524 ? 193.349 151.299 139.364 1.00 40.70  ? 524 TYR A N   1 
ATOM   2333 C CA  . TYR A 1 524 ? 193.408 150.286 138.316 1.00 35.12  ? 524 TYR A CA  1 
ATOM   2334 C C   . TYR A 1 524 ? 192.020 149.978 137.778 1.00 37.99  ? 524 TYR A C   1 
ATOM   2335 O O   . TYR A 1 524 ? 191.827 149.855 136.564 1.00 40.31  ? 524 TYR A O   1 
ATOM   2336 C CB  . TYR A 1 524 ? 194.071 149.021 138.858 1.00 35.79  ? 524 TYR A CB  1 
ATOM   2337 C CG  . TYR A 1 524 ? 194.815 148.202 137.831 1.00 35.02  ? 524 TYR A CG  1 
ATOM   2338 C CD1 . TYR A 1 524 ? 194.514 148.291 136.481 1.00 32.32  ? 524 TYR A CD1 1 
ATOM   2339 C CD2 . TYR A 1 524 ? 195.824 147.335 138.219 1.00 37.94  ? 524 TYR A CD2 1 
ATOM   2340 C CE1 . TYR A 1 524 ? 195.196 147.539 135.549 1.00 33.28  ? 524 TYR A CE1 1 
ATOM   2341 C CE2 . TYR A 1 524 ? 196.509 146.580 137.296 1.00 36.68  ? 524 TYR A CE2 1 
ATOM   2342 C CZ  . TYR A 1 524 ? 196.192 146.685 135.963 1.00 35.88  ? 524 TYR A CZ  1 
ATOM   2343 O OH  . TYR A 1 524 ? 196.882 145.930 135.047 1.00 41.56  ? 524 TYR A OH  1 
ATOM   2344 N N   . THR A 1 525 ? 191.038 149.858 138.670 1.00 39.28  ? 525 THR A N   1 
ATOM   2345 C CA  . THR A 1 525 ? 189.665 149.664 138.229 1.00 38.18  ? 525 THR A CA  1 
ATOM   2346 C C   . THR A 1 525 ? 189.096 150.926 137.596 1.00 41.88  ? 525 THR A C   1 
ATOM   2347 O O   . THR A 1 525 ? 188.294 150.835 136.661 1.00 42.11  ? 525 THR A O   1 
ATOM   2348 C CB  . THR A 1 525 ? 188.796 149.224 139.404 1.00 38.32  ? 525 THR A CB  1 
ATOM   2349 O OG1 . THR A 1 525 ? 188.764 150.263 140.389 1.00 37.73  ? 525 THR A OG1 1 
ATOM   2350 C CG2 . THR A 1 525 ? 189.360 147.966 140.035 1.00 39.51  ? 525 THR A CG2 1 
ATOM   2351 N N   . LEU A 1 526 ? 189.493 152.106 138.082 1.00 41.96  ? 526 LEU A N   1 
ATOM   2352 C CA  . LEU A 1 526 ? 188.880 153.340 137.601 1.00 36.80  ? 526 LEU A CA  1 
ATOM   2353 C C   . LEU A 1 526 ? 189.278 153.636 136.162 1.00 40.80  ? 526 LEU A C   1 
ATOM   2354 O O   . LEU A 1 526 ? 188.419 153.896 135.313 1.00 43.66  ? 526 LEU A O   1 
ATOM   2355 C CB  . LEU A 1 526 ? 189.259 154.506 138.509 1.00 36.40  ? 526 LEU A CB  1 
ATOM   2356 C CG  . LEU A 1 526 ? 188.763 155.886 138.088 1.00 43.17  ? 526 LEU A CG  1 
ATOM   2357 C CD1 . LEU A 1 526 ? 187.249 155.907 138.030 1.00 46.52  ? 526 LEU A CD1 1 
ATOM   2358 C CD2 . LEU A 1 526 ? 189.284 156.936 139.050 1.00 45.49  ? 526 LEU A CD2 1 
ATOM   2359 N N   . ILE A 1 527 ? 190.579 153.584 135.866 1.00 40.79  ? 527 ILE A N   1 
ATOM   2360 C CA  . ILE A 1 527 ? 191.046 153.902 134.519 1.00 37.19  ? 527 ILE A CA  1 
ATOM   2361 C C   . ILE A 1 527 ? 190.425 152.949 133.510 1.00 40.34  ? 527 ILE A C   1 
ATOM   2362 O O   . ILE A 1 527 ? 189.928 153.365 132.456 1.00 44.82  ? 527 ILE A O   1 
ATOM   2363 C CB  . ILE A 1 527 ? 192.583 153.862 134.458 1.00 37.23  ? 527 ILE A CB  1 
ATOM   2364 C CG1 . ILE A 1 527 ? 193.185 154.913 135.389 1.00 36.50  ? 527 ILE A CG1 1 
ATOM   2365 C CG2 . ILE A 1 527 ? 193.063 154.080 133.036 1.00 33.87  ? 527 ILE A CG2 1 
ATOM   2366 C CD1 . ILE A 1 527 ? 194.689 154.995 135.308 1.00 29.79  ? 527 ILE A CD1 1 
ATOM   2367 N N   . TRP A 1 528 ? 190.415 151.654 133.836 1.00 38.01  ? 528 TRP A N   1 
ATOM   2368 C CA  . TRP A 1 528 ? 189.791 150.674 132.957 1.00 36.51  ? 528 TRP A CA  1 
ATOM   2369 C C   . TRP A 1 528 ? 188.322 150.998 132.731 1.00 37.49  ? 528 TRP A C   1 
ATOM   2370 O O   . TRP A 1 528 ? 187.790 150.767 131.639 1.00 41.06  ? 528 TRP A O   1 
ATOM   2371 C CB  . TRP A 1 528 ? 189.947 149.273 133.540 1.00 38.48  ? 528 TRP A CB  1 
ATOM   2372 C CG  . TRP A 1 528 ? 189.753 148.196 132.528 1.00 47.57  ? 528 TRP A CG  1 
ATOM   2373 C CD1 . TRP A 1 528 ? 188.578 147.606 132.174 1.00 45.15  ? 528 TRP A CD1 1 
ATOM   2374 C CD2 . TRP A 1 528 ? 190.767 147.585 131.727 1.00 44.49  ? 528 TRP A CD2 1 
ATOM   2375 N NE1 . TRP A 1 528 ? 188.797 146.661 131.203 1.00 48.40  ? 528 TRP A NE1 1 
ATOM   2376 C CE2 . TRP A 1 528 ? 190.135 146.629 130.912 1.00 44.88  ? 528 TRP A CE2 1 
ATOM   2377 C CE3 . TRP A 1 528 ? 192.149 147.751 131.623 1.00 39.52  ? 528 TRP A CE3 1 
ATOM   2378 C CZ2 . TRP A 1 528 ? 190.836 145.846 130.005 1.00 49.28  ? 528 TRP A CZ2 1 
ATOM   2379 C CZ3 . TRP A 1 528 ? 192.842 146.974 130.724 1.00 41.49  ? 528 TRP A CZ3 1 
ATOM   2380 C CH2 . TRP A 1 528 ? 192.187 146.033 129.926 1.00 52.19  ? 528 TRP A CH2 1 
ATOM   2381 N N   . ASP A 1 529 ? 187.649 151.536 133.750 1.00 36.19  ? 529 ASP A N   1 
ATOM   2382 C CA  . ASP A 1 529 ? 186.263 151.953 133.567 1.00 38.20  ? 529 ASP A CA  1 
ATOM   2383 C C   . ASP A 1 529 ? 186.162 153.083 132.554 1.00 40.10  ? 529 ASP A C   1 
ATOM   2384 O O   . ASP A 1 529 ? 185.271 153.082 131.698 1.00 44.21  ? 529 ASP A O   1 
ATOM   2385 C CB  . ASP A 1 529 ? 185.652 152.382 134.900 1.00 40.82  ? 529 ASP A CB  1 
ATOM   2386 C CG  . ASP A 1 529 ? 185.430 151.222 135.844 1.00 45.88  ? 529 ASP A CG  1 
ATOM   2387 O OD1 . ASP A 1 529 ? 185.788 150.082 135.486 1.00 46.74  ? 529 ASP A OD1 1 
ATOM   2388 O OD2 . ASP A 1 529 ? 184.897 151.451 136.949 1.00 47.01  ? 529 ASP A OD2 1 
ATOM   2389 N N   . LEU A 1 530 ? 187.076 154.051 132.626 1.00 40.93  ? 530 LEU A N   1 
ATOM   2390 C CA  . LEU A 1 530 ? 186.958 155.260 131.826 1.00 37.19  ? 530 LEU A CA  1 
ATOM   2391 C C   . LEU A 1 530 ? 187.647 155.159 130.476 1.00 40.86  ? 530 LEU A C   1 
ATOM   2392 O O   . LEU A 1 530 ? 187.252 155.866 129.544 1.00 48.23  ? 530 LEU A O   1 
ATOM   2393 C CB  . LEU A 1 530 ? 187.531 156.455 132.592 1.00 37.51  ? 530 LEU A CB  1 
ATOM   2394 C CG  . LEU A 1 530 ? 186.957 156.702 133.986 1.00 41.19  ? 530 LEU A CG  1 
ATOM   2395 C CD1 . LEU A 1 530 ? 187.737 157.792 134.694 1.00 40.59  ? 530 LEU A CD1 1 
ATOM   2396 C CD2 . LEU A 1 530 ? 185.486 157.062 133.902 1.00 37.17  ? 530 LEU A CD2 1 
ATOM   2397 N N   . LYS A 1 531 ? 188.658 154.305 130.344 1.00 38.64  ? 531 LYS A N   1 
ATOM   2398 C CA  . LYS A 1 531 ? 189.425 154.210 129.110 1.00 40.38  ? 531 LYS A CA  1 
ATOM   2399 C C   . LYS A 1 531 ? 189.119 152.954 128.310 1.00 45.46  ? 531 LYS A C   1 
ATOM   2400 O O   . LYS A 1 531 ? 189.147 152.991 127.077 1.00 53.34  ? 531 LYS A O   1 
ATOM   2401 C CB  . LYS A 1 531 ? 190.925 154.265 129.416 1.00 42.98  ? 531 LYS A CB  1 
ATOM   2402 C CG  . LYS A 1 531 ? 191.802 154.411 128.185 1.00 52.81  ? 531 LYS A CG  1 
ATOM   2403 C CD  . LYS A 1 531 ? 191.425 155.648 127.388 1.00 50.69  ? 531 LYS A CD  1 
ATOM   2404 C CE  . LYS A 1 531 ? 192.335 155.835 126.184 1.00 60.07  ? 531 LYS A CE  1 
ATOM   2405 N NZ  . LYS A 1 531 ? 192.275 154.680 125.247 1.00 65.96  ? 531 LYS A NZ  1 
ATOM   2406 N N   . MET A 1 532 ? 188.824 151.842 128.979 1.00 41.23  ? 532 MET A N   1 
ATOM   2407 C CA  . MET A 1 532 ? 188.586 150.573 128.305 1.00 40.46  ? 532 MET A CA  1 
ATOM   2408 C C   . MET A 1 532 ? 187.131 150.131 128.351 1.00 41.98  ? 532 MET A C   1 
ATOM   2409 O O   . MET A 1 532 ? 186.586 149.718 127.324 1.00 42.37  ? 532 MET A O   1 
ATOM   2410 C CB  . MET A 1 532 ? 189.473 149.485 128.911 1.00 46.92  ? 532 MET A CB  1 
ATOM   2411 C CG  . MET A 1 532 ? 190.960 149.767 128.792 1.00 48.86  ? 532 MET A CG  1 
ATOM   2412 S SD  . MET A 1 532 ? 191.530 149.800 127.085 1.00 59.91  ? 532 MET A SD  1 
ATOM   2413 C CE  . MET A 1 532 ? 191.183 148.119 126.582 1.00 48.10  ? 532 MET A CE  1 
ATOM   2414 N N   . ASP A 1 533 ? 186.486 150.196 129.517 1.00 40.07  ? 533 ASP A N   1 
ATOM   2415 C CA  . ASP A 1 533 ? 185.079 149.816 129.599 1.00 32.69  ? 533 ASP A CA  1 
ATOM   2416 C C   . ASP A 1 533 ? 184.201 150.784 128.818 1.00 37.55  ? 533 ASP A C   1 
ATOM   2417 O O   . ASP A 1 533 ? 183.383 150.367 127.990 1.00 42.11  ? 533 ASP A O   1 
ATOM   2418 C CB  . ASP A 1 533 ? 184.630 149.748 131.059 1.00 35.76  ? 533 ASP A CB  1 
ATOM   2419 C CG  . ASP A 1 533 ? 185.116 148.500 131.766 1.00 42.19  ? 533 ASP A CG  1 
ATOM   2420 O OD1 . ASP A 1 533 ? 185.480 147.525 131.079 1.00 49.14  ? 533 ASP A OD1 1 
ATOM   2421 O OD2 . ASP A 1 533 ? 185.125 148.487 133.014 1.00 43.13  ? 533 ASP A OD2 1 
ATOM   2422 N N   . TRP A 1 534 ? 184.363 152.085 129.058 1.00 41.11  ? 534 TRP A N   1 
ATOM   2423 C CA  . TRP A 1 534 ? 183.517 153.085 128.422 1.00 33.93  ? 534 TRP A CA  1 
ATOM   2424 C C   . TRP A 1 534 ? 184.102 153.635 127.132 1.00 41.24  ? 534 TRP A C   1 
ATOM   2425 O O   . TRP A 1 534 ? 183.346 154.136 126.293 1.00 44.08  ? 534 TRP A O   1 
ATOM   2426 C CB  . TRP A 1 534 ? 183.251 154.241 129.387 1.00 29.70  ? 534 TRP A CB  1 
ATOM   2427 C CG  . TRP A 1 534 ? 182.473 153.842 130.597 1.00 36.60  ? 534 TRP A CG  1 
ATOM   2428 C CD1 . TRP A 1 534 ? 181.941 152.617 130.860 1.00 37.74  ? 534 TRP A CD1 1 
ATOM   2429 C CD2 . TRP A 1 534 ? 182.137 154.673 131.711 1.00 38.99  ? 534 TRP A CD2 1 
ATOM   2430 N NE1 . TRP A 1 534 ? 181.296 152.631 132.070 1.00 37.44  ? 534 TRP A NE1 1 
ATOM   2431 C CE2 . TRP A 1 534 ? 181.401 153.883 132.613 1.00 33.41  ? 534 TRP A CE2 1 
ATOM   2432 C CE3 . TRP A 1 534 ? 182.386 156.008 132.034 1.00 40.30  ? 534 TRP A CE3 1 
ATOM   2433 C CZ2 . TRP A 1 534 ? 180.912 154.383 133.813 1.00 32.77  ? 534 TRP A CZ2 1 
ATOM   2434 C CZ3 . TRP A 1 534 ? 181.901 156.501 133.224 1.00 48.28  ? 534 TRP A CZ3 1 
ATOM   2435 C CH2 . TRP A 1 534 ? 181.172 155.691 134.100 1.00 41.49  ? 534 TRP A CH2 1 
ATOM   2436 N N   . GLY A 1 535 ? 185.416 153.556 126.950 1.00 42.59  ? 535 GLY A N   1 
ATOM   2437 C CA  . GLY A 1 535 ? 186.040 154.036 125.735 1.00 39.10  ? 535 GLY A CA  1 
ATOM   2438 C C   . GLY A 1 535 ? 186.190 155.534 125.639 1.00 49.50  ? 535 GLY A C   1 
ATOM   2439 O O   . GLY A 1 535 ? 186.457 156.044 124.546 1.00 60.92  ? 535 GLY A O   1 
ATOM   2440 N N   . LEU A 1 536 ? 186.033 156.256 126.742 1.00 49.58  ? 536 LEU A N   1 
ATOM   2441 C CA  . LEU A 1 536 ? 186.124 157.706 126.729 1.00 47.60  ? 536 LEU A CA  1 
ATOM   2442 C C   . LEU A 1 536 ? 187.586 158.142 126.672 1.00 56.01  ? 536 LEU A C   1 
ATOM   2443 O O   . LEU A 1 536 ? 188.508 157.321 126.661 1.00 60.96  ? 536 LEU A O   1 
ATOM   2444 C CB  . LEU A 1 536 ? 185.414 158.285 127.949 1.00 42.94  ? 536 LEU A CB  1 
ATOM   2445 C CG  . LEU A 1 536 ? 183.958 157.841 128.077 1.00 44.94  ? 536 LEU A CG  1 
ATOM   2446 C CD1 . LEU A 1 536 ? 183.346 158.357 129.359 1.00 45.08  ? 536 LEU A CD1 1 
ATOM   2447 C CD2 . LEU A 1 536 ? 183.156 158.302 126.875 1.00 46.27  ? 536 LEU A CD2 1 
ATOM   2448 N N   . PHE A 1 537 ? 187.797 159.459 126.633 1.00 56.81  ? 537 PHE A N   1 
ATOM   2449 C CA  . PHE A 1 537 ? 189.132 160.048 126.508 1.00 55.29  ? 537 PHE A CA  1 
ATOM   2450 C C   . PHE A 1 537 ? 189.846 159.533 125.261 1.00 63.24  ? 537 PHE A C   1 
ATOM   2451 O O   . PHE A 1 537 ? 191.057 159.310 125.262 1.00 61.69  ? 537 PHE A O   1 
ATOM   2452 C CB  . PHE A 1 537 ? 189.970 159.797 127.763 1.00 47.47  ? 537 PHE A CB  1 
ATOM   2453 C CG  . PHE A 1 537 ? 189.401 160.419 129.004 1.00 56.15  ? 537 PHE A CG  1 
ATOM   2454 C CD1 . PHE A 1 537 ? 188.478 159.738 129.776 1.00 58.83  ? 537 PHE A CD1 1 
ATOM   2455 C CD2 . PHE A 1 537 ? 189.790 161.685 129.400 1.00 65.44  ? 537 PHE A CD2 1 
ATOM   2456 C CE1 . PHE A 1 537 ? 187.953 160.310 130.919 1.00 55.66  ? 537 PHE A CE1 1 
ATOM   2457 C CE2 . PHE A 1 537 ? 189.269 162.259 130.542 1.00 66.80  ? 537 PHE A CE2 1 
ATOM   2458 C CZ  . PHE A 1 537 ? 188.349 161.570 131.301 1.00 58.45  ? 537 PHE A CZ  1 
ATOM   2459 N N   . ASP A 1 538 ? 189.085 159.345 124.187 1.00 69.51  ? 538 ASP A N   1 
ATOM   2460 C CA  . ASP A 1 538 ? 189.645 158.851 122.942 1.00 73.27  ? 538 ASP A CA  1 
ATOM   2461 C C   . ASP A 1 538 ? 190.445 159.947 122.245 1.00 80.65  ? 538 ASP A C   1 
ATOM   2462 O O   . ASP A 1 538 ? 190.214 161.143 122.438 1.00 80.14  ? 538 ASP A O   1 
ATOM   2463 C CB  . ASP A 1 538 ? 188.535 158.342 122.022 1.00 76.94  ? 538 ASP A CB  1 
ATOM   2464 C CG  . ASP A 1 538 ? 189.074 157.660 120.782 1.00 85.70  ? 538 ASP A CG  1 
ATOM   2465 O OD1 . ASP A 1 538 ? 189.683 156.578 120.915 1.00 82.48  ? 538 ASP A OD1 1 
ATOM   2466 O OD2 . ASP A 1 538 ? 188.890 158.207 119.674 1.00 86.56  ? 538 ASP A OD2 1 
ATOM   2467 N N   . LYS A 1 539 ? 191.411 159.519 121.429 1.00 86.04  ? 539 LYS A N   1 
ATOM   2468 C CA  . LYS A 1 539 ? 192.233 160.474 120.693 1.00 88.72  ? 539 LYS A CA  1 
ATOM   2469 C C   . LYS A 1 539 ? 191.392 161.277 119.710 1.00 86.06  ? 539 LYS A C   1 
ATOM   2470 O O   . LYS A 1 539 ? 191.528 162.502 119.613 1.00 84.58  ? 539 LYS A O   1 
ATOM   2471 C CB  . LYS A 1 539 ? 193.363 159.746 119.966 1.00 88.73  ? 539 LYS A CB  1 
ATOM   2472 C CG  . LYS A 1 539 ? 194.376 160.683 119.336 1.00 93.00  ? 539 LYS A CG  1 
ATOM   2473 C CD  . LYS A 1 539 ? 195.066 161.522 120.397 1.00 95.52  ? 539 LYS A CD  1 
ATOM   2474 C CE  . LYS A 1 539 ? 195.781 162.714 119.786 1.00 95.32  ? 539 LYS A CE  1 
ATOM   2475 N NZ  . LYS A 1 539 ? 194.818 163.682 119.193 1.00 93.73  ? 539 LYS A NZ  1 
ATOM   2476 N N   . ASN A 1 540 ? 190.509 160.604 118.975 1.00 85.11  ? 540 ASN A N   1 
ATOM   2477 C CA  . ASN A 1 540 ? 189.624 161.273 118.022 1.00 90.86  ? 540 ASN A CA  1 
ATOM   2478 C C   . ASN A 1 540 ? 188.318 161.684 118.704 1.00 88.16  ? 540 ASN A C   1 
ATOM   2479 O O   . ASN A 1 540 ? 187.218 161.315 118.297 1.00 84.85  ? 540 ASN A O   1 
ATOM   2480 C CB  . ASN A 1 540 ? 189.366 160.376 116.817 1.00 90.48  ? 540 ASN A CB  1 
ATOM   2481 C CG  . ASN A 1 540 ? 190.469 160.459 115.781 1.00 96.85  ? 540 ASN A CG  1 
ATOM   2482 O OD1 . ASN A 1 540 ? 191.049 161.522 115.561 1.00 94.69  ? 540 ASN A OD1 1 
ATOM   2483 N ND2 . ASN A 1 540 ? 190.763 159.336 115.137 1.00 99.34  ? 540 ASN A ND2 1 
ATOM   2484 N N   . ALA A 1 541 ? 188.468 162.469 119.772 1.00 87.07  ? 541 ALA A N   1 
ATOM   2485 C CA  . ALA A 1 541 ? 187.302 162.955 120.501 1.00 87.17  ? 541 ALA A CA  1 
ATOM   2486 C C   . ALA A 1 541 ? 186.459 163.880 119.634 1.00 91.88  ? 541 ALA A C   1 
ATOM   2487 O O   . ALA A 1 541 ? 185.224 163.832 119.680 1.00 92.46  ? 541 ALA A O   1 
ATOM   2488 C CB  . ALA A 1 541 ? 187.743 163.667 121.779 1.00 84.19  ? 541 ALA A CB  1 
ATOM   2489 N N   . GLY A 1 542 ? 187.105 164.728 118.838 1.00 90.15  ? 542 GLY A N   1 
ATOM   2490 C CA  . GLY A 1 542 ? 186.359 165.630 117.977 1.00 93.18  ? 542 GLY A CA  1 
ATOM   2491 C C   . GLY A 1 542 ? 185.739 166.768 118.765 1.00 94.50  ? 542 GLY A C   1 
ATOM   2492 O O   . GLY A 1 542 ? 186.340 167.316 119.695 1.00 90.16  ? 542 GLY A O   1 
ATOM   2493 N N   . GLU A 1 543 ? 184.515 167.137 118.379 1.00 97.46  ? 543 GLU A N   1 
ATOM   2494 C CA  . GLU A 1 543 ? 183.812 168.207 119.077 1.00 96.29  ? 543 GLU A CA  1 
ATOM   2495 C C   . GLU A 1 543 ? 183.525 167.826 120.524 1.00 96.22  ? 543 GLU A C   1 
ATOM   2496 O O   . GLU A 1 543 ? 183.624 168.666 121.426 1.00 95.79  ? 543 GLU A O   1 
ATOM   2497 C CB  . GLU A 1 543 ? 182.516 168.550 118.343 1.00 103.46 ? 543 GLU A CB  1 
ATOM   2498 C CG  . GLU A 1 543 ? 181.769 169.740 118.924 1.00 115.01 ? 543 GLU A CG  1 
ATOM   2499 C CD  . GLU A 1 543 ? 180.569 170.141 118.088 1.00 122.07 ? 543 GLU A CD  1 
ATOM   2500 O OE1 . GLU A 1 543 ? 180.350 169.524 117.024 1.00 125.10 ? 543 GLU A OE1 1 
ATOM   2501 O OE2 . GLU A 1 543 ? 179.846 171.075 118.493 1.00 114.25 ? 543 GLU A OE2 1 
ATOM   2502 N N   . ASN A 1 544 ? 183.165 166.567 120.763 1.00 94.87  ? 544 ASN A N   1 
ATOM   2503 C CA  . ASN A 1 544 ? 182.925 166.098 122.121 1.00 90.00  ? 544 ASN A CA  1 
ATOM   2504 C C   . ASN A 1 544 ? 184.219 166.132 122.924 1.00 85.98  ? 544 ASN A C   1 
ATOM   2505 O O   . ASN A 1 544 ? 185.257 165.643 122.471 1.00 86.36  ? 544 ASN A O   1 
ATOM   2506 C CB  . ASN A 1 544 ? 182.354 164.683 122.096 1.00 82.29  ? 544 ASN A CB  1 
ATOM   2507 C CG  . ASN A 1 544 ? 181.077 164.587 121.291 1.00 83.27  ? 544 ASN A CG  1 
ATOM   2508 O OD1 . ASN A 1 544 ? 180.242 165.490 121.321 1.00 85.83  ? 544 ASN A OD1 1 
ATOM   2509 N ND2 . ASN A 1 544 ? 180.920 163.490 120.561 1.00 77.40  ? 544 ASN A ND2 1 
ATOM   2510 N N   . THR A 1 545 ? 184.155 166.706 124.121 1.00 82.36  ? 545 THR A N   1 
ATOM   2511 C CA  . THR A 1 545 ? 185.321 166.863 124.977 1.00 82.07  ? 545 THR A CA  1 
ATOM   2512 C C   . THR A 1 545 ? 185.395 165.695 125.949 1.00 79.91  ? 545 THR A C   1 
ATOM   2513 O O   . THR A 1 545 ? 184.411 165.389 126.629 1.00 80.49  ? 545 THR A O   1 
ATOM   2514 C CB  . THR A 1 545 ? 185.264 168.184 125.746 1.00 81.82  ? 545 THR A CB  1 
ATOM   2515 O OG1 . THR A 1 545 ? 185.231 169.277 124.820 1.00 86.74  ? 545 THR A OG1 1 
ATOM   2516 C CG2 . THR A 1 545 ? 186.477 168.328 126.651 1.00 75.46  ? 545 THR A CG2 1 
ATOM   2517 N N   . PHE A 1 546 ? 186.552 165.035 125.992 1.00 77.51  ? 546 PHE A N   1 
ATOM   2518 C CA  . PHE A 1 546 ? 186.867 163.908 126.866 1.00 73.25  ? 546 PHE A CA  1 
ATOM   2519 C C   . PHE A 1 546 ? 186.067 162.656 126.532 1.00 65.86  ? 546 PHE A C   1 
ATOM   2520 O O   . PHE A 1 546 ? 186.285 161.616 127.160 1.00 60.97  ? 546 PHE A O   1 
ATOM   2521 C CB  . PHE A 1 546 ? 186.665 164.242 128.351 1.00 73.87  ? 546 PHE A CB  1 
ATOM   2522 C CG  . PHE A 1 546 ? 187.556 165.341 128.853 1.00 86.56  ? 546 PHE A CG  1 
ATOM   2523 C CD1 . PHE A 1 546 ? 188.777 165.594 128.250 1.00 89.67  ? 546 PHE A CD1 1 
ATOM   2524 C CD2 . PHE A 1 546 ? 187.173 166.123 129.930 1.00 87.99  ? 546 PHE A CD2 1 
ATOM   2525 C CE1 . PHE A 1 546 ? 189.598 166.604 128.711 1.00 90.57  ? 546 PHE A CE1 1 
ATOM   2526 C CE2 . PHE A 1 546 ? 187.989 167.134 130.396 1.00 91.22  ? 546 PHE A CE2 1 
ATOM   2527 C CZ  . PHE A 1 546 ? 189.203 167.375 129.786 1.00 91.65  ? 546 PHE A CZ  1 
ATOM   2528 N N   . LEU A 1 547 ? 185.151 162.716 125.576 1.00 66.93  ? 547 LEU A N   1 
ATOM   2529 C CA  . LEU A 1 547 ? 184.375 161.567 125.154 1.00 60.30  ? 547 LEU A CA  1 
ATOM   2530 C C   . LEU A 1 547 ? 184.938 161.035 123.840 1.00 68.71  ? 547 LEU A C   1 
ATOM   2531 O O   . LEU A 1 547 ? 185.986 161.477 123.363 1.00 75.71  ? 547 LEU A O   1 
ATOM   2532 C CB  . LEU A 1 547 ? 182.898 161.941 125.031 1.00 57.29  ? 547 LEU A CB  1 
ATOM   2533 C CG  . LEU A 1 547 ? 182.281 162.672 126.221 1.00 55.35  ? 547 LEU A CG  1 
ATOM   2534 C CD1 . LEU A 1 547 ? 180.793 162.862 125.999 1.00 55.46  ? 547 LEU A CD1 1 
ATOM   2535 C CD2 . LEU A 1 547 ? 182.546 161.928 127.517 1.00 51.19  ? 547 LEU A CD2 1 
ATOM   2536 N N   . ARG A 1 548 ? 184.241 160.074 123.244 1.00 63.67  ? 548 ARG A N   1 
ATOM   2537 C CA  . ARG A 1 548 ? 184.662 159.497 121.981 1.00 67.94  ? 548 ARG A CA  1 
ATOM   2538 C C   . ARG A 1 548 ? 184.011 160.241 120.816 1.00 72.54  ? 548 ARG A C   1 
ATOM   2539 O O   . ARG A 1 548 ? 183.220 161.169 120.997 1.00 69.19  ? 548 ARG A O   1 
ATOM   2540 C CB  . ARG A 1 548 ? 184.336 158.006 121.947 1.00 67.18  ? 548 ARG A CB  1 
ATOM   2541 C CG  . ARG A 1 548 ? 183.214 157.608 122.881 1.00 63.44  ? 548 ARG A CG  1 
ATOM   2542 C CD  . ARG A 1 548 ? 183.087 156.103 122.980 1.00 52.61  ? 548 ARG A CD  1 
ATOM   2543 N NE  . ARG A 1 548 ? 182.379 155.713 124.191 1.00 54.44  ? 548 ARG A NE  1 
ATOM   2544 C CZ  . ARG A 1 548 ? 181.061 155.627 124.287 1.00 49.67  ? 548 ARG A CZ  1 
ATOM   2545 N NH1 . ARG A 1 548 ? 180.277 155.882 123.255 1.00 46.76  ? 548 ARG A NH1 1 
ATOM   2546 N NH2 . ARG A 1 548 ? 180.518 155.278 125.450 1.00 43.74  ? 548 ARG A NH2 1 
ATOM   2547 N N   . GLU A 1 549 ? 184.362 159.829 119.596 1.00 77.80  ? 549 GLU A N   1 
ATOM   2548 C CA  . GLU A 1 549 ? 183.847 160.499 118.407 1.00 80.29  ? 549 GLU A CA  1 
ATOM   2549 C C   . GLU A 1 549 ? 182.338 160.341 118.286 1.00 81.86  ? 549 GLU A C   1 
ATOM   2550 O O   . GLU A 1 549 ? 181.631 161.296 117.946 1.00 85.47  ? 549 GLU A O   1 
ATOM   2551 C CB  . GLU A 1 549 ? 184.549 159.959 117.160 1.00 79.88  ? 549 GLU A CB  1 
ATOM   2552 C CG  . GLU A 1 549 ? 184.001 160.493 115.848 1.00 85.33  ? 549 GLU A CG  1 
ATOM   2553 C CD  . GLU A 1 549 ? 183.012 159.544 115.199 1.00 93.71  ? 549 GLU A CD  1 
ATOM   2554 O OE1 . GLU A 1 549 ? 183.157 158.318 115.383 1.00 95.40  ? 549 GLU A OE1 1 
ATOM   2555 O OE2 . GLU A 1 549 ? 182.088 160.024 114.509 1.00 92.27  ? 549 GLU A OE2 1 
ATOM   2556 N N   . GLU A 1 550 ? 181.825 159.148 118.567 1.00 79.54  ? 550 GLU A N   1 
ATOM   2557 C CA  . GLU A 1 550 ? 180.408 158.844 118.424 1.00 76.88  ? 550 GLU A CA  1 
ATOM   2558 C C   . GLU A 1 550 ? 179.760 158.746 119.798 1.00 72.31  ? 550 GLU A C   1 
ATOM   2559 O O   . GLU A 1 550 ? 180.260 158.040 120.679 1.00 69.99  ? 550 GLU A O   1 
ATOM   2560 C CB  . GLU A 1 550 ? 180.210 157.547 117.637 1.00 74.90  ? 550 GLU A CB  1 
ATOM   2561 C CG  . GLU A 1 550 ? 181.380 156.584 117.739 1.00 83.93  ? 550 GLU A CG  1 
ATOM   2562 C CD  . GLU A 1 550 ? 181.300 155.459 116.726 1.00 94.51  ? 550 GLU A CD  1 
ATOM   2563 O OE1 . GLU A 1 550 ? 180.285 155.380 116.003 1.00 88.10  ? 550 GLU A OE1 1 
ATOM   2564 O OE2 . GLU A 1 550 ? 182.254 154.656 116.650 1.00 100.05 ? 550 GLU A OE2 1 
ATOM   2565 N N   . ILE A 1 551 ? 178.653 159.461 119.973 1.00 68.00  ? 551 ILE A N   1 
ATOM   2566 C CA  . ILE A 1 551 ? 177.906 159.502 121.223 1.00 59.40  ? 551 ILE A CA  1 
ATOM   2567 C C   . ILE A 1 551 ? 176.490 159.022 120.940 1.00 62.36  ? 551 ILE A C   1 
ATOM   2568 O O   . ILE A 1 551 ? 175.825 159.538 120.035 1.00 66.85  ? 551 ILE A O   1 
ATOM   2569 C CB  . ILE A 1 551 ? 177.898 160.918 121.828 1.00 55.91  ? 551 ILE A CB  1 
ATOM   2570 C CG1 . ILE A 1 551 ? 179.266 161.249 122.421 1.00 60.18  ? 551 ILE A CG1 1 
ATOM   2571 C CG2 . ILE A 1 551 ? 176.802 161.061 122.863 1.00 57.47  ? 551 ILE A CG2 1 
ATOM   2572 C CD1 . ILE A 1 551 ? 179.773 160.216 123.392 1.00 58.66  ? 551 ILE A CD1 1 
ATOM   2573 N N   . VAL A 1 552 ? 176.034 158.039 121.711 1.00 56.59  ? 552 VAL A N   1 
ATOM   2574 C CA  . VAL A 1 552 ? 174.730 157.429 121.466 1.00 51.98  ? 552 VAL A CA  1 
ATOM   2575 C C   . VAL A 1 552 ? 173.629 158.109 122.270 1.00 54.92  ? 552 VAL A C   1 
ATOM   2576 O O   . VAL A 1 552 ? 172.551 158.390 121.740 1.00 55.36  ? 552 VAL A O   1 
ATOM   2577 C CB  . VAL A 1 552 ? 174.801 155.920 121.767 1.00 51.24  ? 552 VAL A CB  1 
ATOM   2578 C CG1 . VAL A 1 552 ? 173.434 155.297 121.656 1.00 51.60  ? 552 VAL A CG1 1 
ATOM   2579 C CG2 . VAL A 1 552 ? 175.758 155.243 120.811 1.00 54.65  ? 552 VAL A CG2 1 
ATOM   2580 N N   . TYR A 1 553 ? 173.871 158.381 123.543 1.00 57.14  ? 553 TYR A N   1 
ATOM   2581 C CA  . TYR A 1 553 ? 172.845 158.957 124.397 1.00 55.99  ? 553 TYR A CA  1 
ATOM   2582 C C   . TYR A 1 553 ? 172.643 160.440 124.080 1.00 67.82  ? 553 TYR A C   1 
ATOM   2583 O O   . TYR A 1 553 ? 173.580 161.125 123.662 1.00 68.69  ? 553 TYR A O   1 
ATOM   2584 C CB  . TYR A 1 553 ? 173.216 158.758 125.861 1.00 44.26  ? 553 TYR A CB  1 
ATOM   2585 C CG  . TYR A 1 553 ? 173.340 157.290 126.193 1.00 44.14  ? 553 TYR A CG  1 
ATOM   2586 C CD1 . TYR A 1 553 ? 172.217 156.478 126.239 1.00 47.81  ? 553 TYR A CD1 1 
ATOM   2587 C CD2 . TYR A 1 553 ? 174.576 156.708 126.418 1.00 39.60  ? 553 TYR A CD2 1 
ATOM   2588 C CE1 . TYR A 1 553 ? 172.319 155.134 126.519 1.00 41.37  ? 553 TYR A CE1 1 
ATOM   2589 C CE2 . TYR A 1 553 ? 174.686 155.363 126.702 1.00 39.64  ? 553 TYR A CE2 1 
ATOM   2590 C CZ  . TYR A 1 553 ? 173.554 154.581 126.750 1.00 43.00  ? 553 TYR A CZ  1 
ATOM   2591 O OH  . TYR A 1 553 ? 173.652 153.239 127.032 1.00 43.43  ? 553 TYR A OH  1 
ATOM   2592 N N   . PRO A 1 554 ? 171.416 160.948 124.256 1.00 70.74  ? 554 PRO A N   1 
ATOM   2593 C CA  . PRO A 1 554 ? 171.085 162.276 123.705 1.00 67.27  ? 554 PRO A CA  1 
ATOM   2594 C C   . PRO A 1 554 ? 171.962 163.409 124.208 1.00 68.90  ? 554 PRO A C   1 
ATOM   2595 O O   . PRO A 1 554 ? 172.311 164.302 123.428 1.00 75.49  ? 554 PRO A O   1 
ATOM   2596 C CB  . PRO A 1 554 ? 169.623 162.468 124.131 1.00 67.84  ? 554 PRO A CB  1 
ATOM   2597 C CG  . PRO A 1 554 ? 169.102 161.092 124.339 1.00 70.50  ? 554 PRO A CG  1 
ATOM   2598 C CD  . PRO A 1 554 ? 170.249 160.309 124.887 1.00 67.91  ? 554 PRO A CD  1 
ATOM   2599 N N   . GLN A 1 555 ? 172.331 163.402 125.483 1.00 67.68  ? 555 GLN A N   1 
ATOM   2600 C CA  . GLN A 1 555 ? 173.081 164.496 126.084 1.00 64.22  ? 555 GLN A CA  1 
ATOM   2601 C C   . GLN A 1 555 ? 174.465 164.012 126.485 1.00 61.65  ? 555 GLN A C   1 
ATOM   2602 O O   . GLN A 1 555 ? 174.595 162.996 127.174 1.00 65.61  ? 555 GLN A O   1 
ATOM   2603 C CB  . GLN A 1 555 ? 172.350 165.056 127.306 1.00 60.17  ? 555 GLN A CB  1 
ATOM   2604 C CG  . GLN A 1 555 ? 171.006 165.686 126.998 1.00 64.08  ? 555 GLN A CG  1 
ATOM   2605 C CD  . GLN A 1 555 ? 170.355 166.281 128.227 1.00 74.22  ? 555 GLN A CD  1 
ATOM   2606 O OE1 . GLN A 1 555 ? 170.915 166.238 129.321 1.00 74.04  ? 555 GLN A OE1 1 
ATOM   2607 N NE2 . GLN A 1 555 ? 169.165 166.841 128.054 1.00 81.82  ? 555 GLN A NE2 1 
ATOM   2608 N N   . LYS A 1 556 ? 175.496 164.742 126.056 1.00 59.18  ? 556 LYS A N   1 
ATOM   2609 C CA  . LYS A 1 556 ? 176.842 164.421 126.506 1.00 58.27  ? 556 LYS A CA  1 
ATOM   2610 C C   . LYS A 1 556 ? 177.045 164.766 127.975 1.00 55.06  ? 556 LYS A C   1 
ATOM   2611 O O   . LYS A 1 556 ? 177.955 164.219 128.607 1.00 55.97  ? 556 LYS A O   1 
ATOM   2612 C CB  . LYS A 1 556 ? 177.880 165.136 125.640 1.00 64.36  ? 556 LYS A CB  1 
ATOM   2613 C CG  . LYS A 1 556 ? 177.799 166.649 125.666 1.00 71.78  ? 556 LYS A CG  1 
ATOM   2614 C CD  . LYS A 1 556 ? 178.878 167.257 124.783 1.00 77.71  ? 556 LYS A CD  1 
ATOM   2615 C CE  . LYS A 1 556 ? 178.821 168.775 124.795 1.00 79.35  ? 556 LYS A CE  1 
ATOM   2616 N NZ  . LYS A 1 556 ? 179.856 169.370 123.904 1.00 85.69  ? 556 LYS A NZ  1 
ATOM   2617 N N   . ALA A 1 557 ? 176.204 165.640 128.533 1.00 53.47  ? 557 ALA A N   1 
ATOM   2618 C CA  . ALA A 1 557 ? 176.283 165.938 129.958 1.00 54.11  ? 557 ALA A CA  1 
ATOM   2619 C C   . ALA A 1 557 ? 176.097 164.677 130.790 1.00 55.67  ? 557 ALA A C   1 
ATOM   2620 O O   . ALA A 1 557 ? 176.767 164.498 131.816 1.00 50.79  ? 557 ALA A O   1 
ATOM   2621 C CB  . ALA A 1 557 ? 175.240 166.989 130.335 1.00 47.33  ? 557 ALA A CB  1 
ATOM   2622 N N   . TYR A 1 558 ? 175.216 163.776 130.340 1.00 57.24  ? 558 TYR A N   1 
ATOM   2623 C CA  . TYR A 1 558 ? 175.017 162.506 131.032 1.00 48.30  ? 558 TYR A CA  1 
ATOM   2624 C C   . TYR A 1 558 ? 176.339 161.789 131.244 1.00 49.73  ? 558 TYR A C   1 
ATOM   2625 O O   . TYR A 1 558 ? 176.538 161.123 132.266 1.00 51.72  ? 558 TYR A O   1 
ATOM   2626 C CB  . TYR A 1 558 ? 174.067 161.608 130.237 1.00 40.01  ? 558 TYR A CB  1 
ATOM   2627 C CG  . TYR A 1 558 ? 172.606 161.955 130.367 1.00 49.98  ? 558 TYR A CG  1 
ATOM   2628 C CD1 . TYR A 1 558 ? 172.125 162.619 131.484 1.00 51.21  ? 558 TYR A CD1 1 
ATOM   2629 C CD2 . TYR A 1 558 ? 171.704 161.610 129.370 1.00 56.36  ? 558 TYR A CD2 1 
ATOM   2630 C CE1 . TYR A 1 558 ? 170.788 162.933 131.604 1.00 51.80  ? 558 TYR A CE1 1 
ATOM   2631 C CE2 . TYR A 1 558 ? 170.367 161.921 129.480 1.00 53.52  ? 558 TYR A CE2 1 
ATOM   2632 C CZ  . TYR A 1 558 ? 169.914 162.582 130.598 1.00 57.51  ? 558 TYR A CZ  1 
ATOM   2633 O OH  . TYR A 1 558 ? 168.580 162.892 130.711 1.00 68.21  ? 558 TYR A OH  1 
ATOM   2634 N N   . TYR A 1 559 ? 177.256 161.916 130.287 1.00 48.96  ? 559 TYR A N   1 
ATOM   2635 C CA  . TYR A 1 559 ? 178.566 161.297 130.436 1.00 45.75  ? 559 TYR A CA  1 
ATOM   2636 C C   . TYR A 1 559 ? 179.353 161.946 131.564 1.00 46.96  ? 559 TYR A C   1 
ATOM   2637 O O   . TYR A 1 559 ? 179.846 161.257 132.465 1.00 51.25  ? 559 TYR A O   1 
ATOM   2638 C CB  . TYR A 1 559 ? 179.336 161.385 129.120 1.00 44.28  ? 559 TYR A CB  1 
ATOM   2639 C CG  . TYR A 1 559 ? 178.705 160.617 127.981 1.00 40.97  ? 559 TYR A CG  1 
ATOM   2640 C CD1 . TYR A 1 559 ? 177.566 161.089 127.349 1.00 41.29  ? 559 TYR A CD1 1 
ATOM   2641 C CD2 . TYR A 1 559 ? 179.257 159.430 127.532 1.00 37.43  ? 559 TYR A CD2 1 
ATOM   2642 C CE1 . TYR A 1 559 ? 176.989 160.398 126.314 1.00 42.35  ? 559 TYR A CE1 1 
ATOM   2643 C CE2 . TYR A 1 559 ? 178.689 158.733 126.493 1.00 43.29  ? 559 TYR A CE2 1 
ATOM   2644 C CZ  . TYR A 1 559 ? 177.554 159.221 125.887 1.00 47.88  ? 559 TYR A CZ  1 
ATOM   2645 O OH  . TYR A 1 559 ? 176.979 158.528 124.850 1.00 55.29  ? 559 TYR A OH  1 
ATOM   2646 N N   . TYR A 1 560 ? 179.446 163.280 131.557 1.00 48.02  ? 560 TYR A N   1 
ATOM   2647 C CA  . TYR A 1 560 ? 180.403 163.952 132.432 1.00 49.57  ? 560 TYR A CA  1 
ATOM   2648 C C   . TYR A 1 560 ? 180.090 163.698 133.898 1.00 50.54  ? 560 TYR A C   1 
ATOM   2649 O O   . TYR A 1 560 ? 180.957 163.233 134.649 1.00 47.95  ? 560 TYR A O   1 
ATOM   2650 C CB  . TYR A 1 560 ? 180.429 165.448 132.132 1.00 48.97  ? 560 TYR A CB  1 
ATOM   2651 C CG  . TYR A 1 560 ? 180.915 165.760 130.737 1.00 54.57  ? 560 TYR A CG  1 
ATOM   2652 C CD1 . TYR A 1 560 ? 182.248 165.596 130.396 1.00 54.97  ? 560 TYR A CD1 1 
ATOM   2653 C CD2 . TYR A 1 560 ? 180.040 166.211 129.761 1.00 55.11  ? 560 TYR A CD2 1 
ATOM   2654 C CE1 . TYR A 1 560 ? 182.697 165.874 129.124 1.00 62.89  ? 560 TYR A CE1 1 
ATOM   2655 C CE2 . TYR A 1 560 ? 180.480 166.493 128.484 1.00 60.86  ? 560 TYR A CE2 1 
ATOM   2656 C CZ  . TYR A 1 560 ? 181.809 166.323 128.171 1.00 68.29  ? 560 TYR A CZ  1 
ATOM   2657 O OH  . TYR A 1 560 ? 182.250 166.603 126.898 1.00 69.29  ? 560 TYR A OH  1 
ATOM   2658 N N   . CYS A 1 561 ? 178.848 163.954 134.313 1.00 52.39  ? 561 CYS A N   1 
ATOM   2659 C CA  . CYS A 1 561 ? 178.451 163.611 135.672 1.00 54.15  ? 561 CYS A CA  1 
ATOM   2660 C C   . CYS A 1 561 ? 178.722 162.142 135.954 1.00 50.08  ? 561 CYS A C   1 
ATOM   2661 O O   . CYS A 1 561 ? 179.307 161.801 136.990 1.00 52.92  ? 561 CYS A O   1 
ATOM   2662 C CB  . CYS A 1 561 ? 176.975 163.945 135.893 1.00 65.59  ? 561 CYS A CB  1 
ATOM   2663 S SG  . CYS A 1 561 ? 175.844 163.217 134.688 1.00 106.50 ? 561 CYS A SG  1 
ATOM   2664 N N   . ALA A 1 562 ? 178.364 161.265 135.008 1.00 49.86  ? 562 ALA A N   1 
ATOM   2665 C CA  . ALA A 1 562 ? 178.650 159.845 135.171 1.00 46.26  ? 562 ALA A CA  1 
ATOM   2666 C C   . ALA A 1 562 ? 180.126 159.620 135.451 1.00 47.22  ? 562 ALA A C   1 
ATOM   2667 O O   . ALA A 1 562 ? 180.480 158.910 136.401 1.00 50.10  ? 562 ALA A O   1 
ATOM   2668 C CB  . ALA A 1 562 ? 178.219 159.069 133.930 1.00 44.18  ? 562 ALA A CB  1 
ATOM   2669 N N   . ILE A 1 563 ? 181.000 160.270 134.676 1.00 44.37  ? 563 ILE A N   1 
ATOM   2670 C CA  . ILE A 1 563 ? 182.429 160.132 134.924 1.00 42.34  ? 563 ILE A CA  1 
ATOM   2671 C C   . ILE A 1 563 ? 182.740 160.516 136.359 1.00 44.59  ? 563 ILE A C   1 
ATOM   2672 O O   . ILE A 1 563 ? 183.306 159.719 137.119 1.00 50.35  ? 563 ILE A O   1 
ATOM   2673 C CB  . ILE A 1 563 ? 183.234 160.983 133.926 1.00 39.89  ? 563 ILE A CB  1 
ATOM   2674 C CG1 . ILE A 1 563 ? 183.097 160.431 132.509 1.00 42.31  ? 563 ILE A CG1 1 
ATOM   2675 C CG2 . ILE A 1 563 ? 184.693 161.043 134.335 1.00 38.14  ? 563 ILE A CG2 1 
ATOM   2676 C CD1 . ILE A 1 563 ? 183.899 161.200 131.485 1.00 43.75  ? 563 ILE A CD1 1 
ATOM   2677 N N   . ILE A 1 564 ? 182.279 161.696 136.781 1.00 45.63  ? 564 ILE A N   1 
ATOM   2678 C CA  . ILE A 1 564 ? 182.485 162.109 138.161 1.00 40.95  ? 564 ILE A CA  1 
ATOM   2679 C C   . ILE A 1 564 ? 181.900 161.072 139.100 1.00 41.80  ? 564 ILE A C   1 
ATOM   2680 O O   . ILE A 1 564 ? 182.573 160.607 140.030 1.00 44.24  ? 564 ILE A O   1 
ATOM   2681 C CB  . ILE A 1 564 ? 181.877 163.502 138.404 1.00 41.72  ? 564 ILE A CB  1 
ATOM   2682 C CG1 . ILE A 1 564 ? 182.594 164.553 137.557 1.00 44.01  ? 564 ILE A CG1 1 
ATOM   2683 C CG2 . ILE A 1 564 ? 181.943 163.863 139.875 1.00 35.99  ? 564 ILE A CG2 1 
ATOM   2684 C CD1 . ILE A 1 564 ? 182.035 165.945 137.722 1.00 49.96  ? 564 ILE A CD1 1 
ATOM   2685 N N   . GLU A 1 565 ? 180.669 160.636 138.823 1.00 44.42  ? 565 GLU A N   1 
ATOM   2686 C CA  . GLU A 1 565 ? 180.033 159.628 139.659 1.00 43.34  ? 565 GLU A CA  1 
ATOM   2687 C C   . GLU A 1 565 ? 180.938 158.417 139.802 1.00 50.41  ? 565 GLU A C   1 
ATOM   2688 O O   . GLU A 1 565 ? 181.224 157.969 140.919 1.00 52.72  ? 565 GLU A O   1 
ATOM   2689 C CB  . GLU A 1 565 ? 178.680 159.240 139.065 1.00 50.60  ? 565 GLU A CB  1 
ATOM   2690 C CG  . GLU A 1 565 ? 177.892 158.242 139.891 1.00 65.60  ? 565 GLU A CG  1 
ATOM   2691 C CD  . GLU A 1 565 ? 177.911 156.850 139.296 1.00 66.33  ? 565 GLU A CD  1 
ATOM   2692 O OE1 . GLU A 1 565 ? 178.799 156.564 138.468 1.00 62.92  ? 565 GLU A OE1 1 
ATOM   2693 O OE2 . GLU A 1 565 ? 177.030 156.044 139.653 1.00 50.07  ? 565 GLU A OE2 1 
ATOM   2694 N N   . ASP A 1 566 ? 181.470 157.929 138.678 1.00 48.45  ? 566 ASP A N   1 
ATOM   2695 C CA  . ASP A 1 566 ? 182.345 156.767 138.732 1.00 40.26  ? 566 ASP A CA  1 
ATOM   2696 C C   . ASP A 1 566 ? 183.524 157.036 139.652 1.00 36.68  ? 566 ASP A C   1 
ATOM   2697 O O   . ASP A 1 566 ? 183.785 156.270 140.588 1.00 41.86  ? 566 ASP A O   1 
ATOM   2698 C CB  . ASP A 1 566 ? 182.821 156.407 137.325 1.00 41.22  ? 566 ASP A CB  1 
ATOM   2699 C CG  . ASP A 1 566 ? 182.912 154.913 137.104 1.00 51.25  ? 566 ASP A CG  1 
ATOM   2700 O OD1 . ASP A 1 566 ? 181.852 154.268 136.962 1.00 52.02  ? 566 ASP A OD1 1 
ATOM   2701 O OD2 . ASP A 1 566 ? 184.040 154.382 137.071 1.00 51.99  ? 566 ASP A OD2 1 
ATOM   2702 N N   . VAL A 1 567 ? 184.193 158.174 139.454 1.00 39.03  ? 567 VAL A N   1 
ATOM   2703 C CA  . VAL A 1 567 ? 185.363 158.491 140.264 1.00 37.35  ? 567 VAL A CA  1 
ATOM   2704 C C   . VAL A 1 567 ? 184.969 158.614 141.727 1.00 41.21  ? 567 VAL A C   1 
ATOM   2705 O O   . VAL A 1 567 ? 185.734 158.244 142.625 1.00 38.60  ? 567 VAL A O   1 
ATOM   2706 C CB  . VAL A 1 567 ? 186.042 159.772 139.745 1.00 35.92  ? 567 VAL A CB  1 
ATOM   2707 C CG1 . VAL A 1 567 ? 187.285 160.081 140.558 1.00 36.70  ? 567 VAL A CG1 1 
ATOM   2708 C CG2 . VAL A 1 567 ? 186.388 159.624 138.274 1.00 33.55  ? 567 VAL A CG2 1 
ATOM   2709 N N   . ILE A 1 568 ? 183.765 159.121 141.991 1.00 43.28  ? 568 ILE A N   1 
ATOM   2710 C CA  . ILE A 1 568 ? 183.320 159.238 143.373 1.00 38.81  ? 568 ILE A CA  1 
ATOM   2711 C C   . ILE A 1 568 ? 183.038 157.861 143.956 1.00 36.57  ? 568 ILE A C   1 
ATOM   2712 O O   . ILE A 1 568 ? 183.363 157.586 145.117 1.00 40.48  ? 568 ILE A O   1 
ATOM   2713 C CB  . ILE A 1 568 ? 182.095 160.163 143.467 1.00 35.26  ? 568 ILE A CB  1 
ATOM   2714 C CG1 . ILE A 1 568 ? 182.488 161.597 143.115 1.00 34.53  ? 568 ILE A CG1 1 
ATOM   2715 C CG2 . ILE A 1 568 ? 181.492 160.112 144.859 1.00 43.61  ? 568 ILE A CG2 1 
ATOM   2716 C CD1 . ILE A 1 568 ? 181.365 162.592 143.274 1.00 28.52  ? 568 ILE A CD1 1 
ATOM   2717 N N   . LEU A 1 569 ? 182.455 156.965 143.159 1.00 33.04  ? 569 LEU A N   1 
ATOM   2718 C CA  . LEU A 1 569 ? 181.953 155.715 143.709 1.00 29.01  ? 569 LEU A CA  1 
ATOM   2719 C C   . LEU A 1 569 ? 182.954 154.573 143.637 1.00 33.51  ? 569 LEU A C   1 
ATOM   2720 O O   . LEU A 1 569 ? 182.909 153.686 144.496 1.00 37.48  ? 569 LEU A O   1 
ATOM   2721 C CB  . LEU A 1 569 ? 180.655 155.314 143.005 1.00 31.21  ? 569 LEU A CB  1 
ATOM   2722 C CG  . LEU A 1 569 ? 179.452 156.180 143.379 1.00 32.17  ? 569 LEU A CG  1 
ATOM   2723 C CD1 . LEU A 1 569 ? 178.205 155.719 142.657 1.00 25.56  ? 569 LEU A CD1 1 
ATOM   2724 C CD2 . LEU A 1 569 ? 179.234 156.161 144.879 1.00 31.02  ? 569 LEU A CD2 1 
ATOM   2725 N N   . ARG A 1 570 ? 183.863 154.582 142.659 1.00 33.90  ? 570 ARG A N   1 
ATOM   2726 C CA  . ARG A 1 570 ? 184.884 153.541 142.596 1.00 32.92  ? 570 ARG A CA  1 
ATOM   2727 C C   . ARG A 1 570 ? 185.652 153.454 143.908 1.00 35.44  ? 570 ARG A C   1 
ATOM   2728 O O   . ARG A 1 570 ? 185.733 152.384 144.523 1.00 38.24  ? 570 ARG A O   1 
ATOM   2729 C CB  . ARG A 1 570 ? 185.835 153.803 141.429 1.00 36.09  ? 570 ARG A CB  1 
ATOM   2730 C CG  . ARG A 1 570 ? 185.505 153.009 140.180 1.00 37.08  ? 570 ARG A CG  1 
ATOM   2731 C CD  . ARG A 1 570 ? 185.445 151.530 140.500 1.00 38.67  ? 570 ARG A CD  1 
ATOM   2732 N NE  . ARG A 1 570 ? 185.314 150.700 139.310 1.00 38.67  ? 570 ARG A NE  1 
ATOM   2733 C CZ  . ARG A 1 570 ? 185.170 149.382 139.335 1.00 38.95  ? 570 ARG A CZ  1 
ATOM   2734 N NH1 . ARG A 1 570 ? 185.110 148.716 140.475 1.00 36.19  ? 570 ARG A NH1 1 
ATOM   2735 N NH2 . ARG A 1 570 ? 185.085 148.717 138.188 1.00 40.69  ? 570 ARG A NH2 1 
ATOM   2736 N N   . PHE A 1 571 ? 186.180 154.586 144.379 1.00 37.66  ? 571 PHE A N   1 
ATOM   2737 C CA  . PHE A 1 571 ? 186.796 154.611 145.701 1.00 40.25  ? 571 PHE A CA  1 
ATOM   2738 C C   . PHE A 1 571 ? 185.803 154.175 146.767 1.00 41.71  ? 571 PHE A C   1 
ATOM   2739 O O   . PHE A 1 571 ? 186.130 153.353 147.631 1.00 47.00  ? 571 PHE A O   1 
ATOM   2740 C CB  . PHE A 1 571 ? 187.335 156.008 146.009 1.00 38.39  ? 571 PHE A CB  1 
ATOM   2741 C CG  . PHE A 1 571 ? 188.534 156.388 145.193 1.00 41.97  ? 571 PHE A CG  1 
ATOM   2742 C CD1 . PHE A 1 571 ? 188.386 156.942 143.935 1.00 43.37  ? 571 PHE A CD1 1 
ATOM   2743 C CD2 . PHE A 1 571 ? 189.811 156.193 145.685 1.00 40.81  ? 571 PHE A CD2 1 
ATOM   2744 C CE1 . PHE A 1 571 ? 189.487 157.290 143.183 1.00 42.00  ? 571 PHE A CE1 1 
ATOM   2745 C CE2 . PHE A 1 571 ? 190.916 156.541 144.936 1.00 41.23  ? 571 PHE A CE2 1 
ATOM   2746 C CZ  . PHE A 1 571 ? 190.753 157.090 143.684 1.00 43.44  ? 571 PHE A CZ  1 
ATOM   2747 N N   . ALA A 1 572 ? 184.572 154.689 146.699 1.00 40.22  ? 572 ALA A N   1 
ATOM   2748 C CA  . ALA A 1 572 ? 183.552 154.288 147.660 1.00 38.73  ? 572 ALA A CA  1 
ATOM   2749 C C   . ALA A 1 572 ? 183.284 152.794 147.586 1.00 41.45  ? 572 ALA A C   1 
ATOM   2750 O O   . ALA A 1 572 ? 182.908 152.181 148.590 1.00 46.82  ? 572 ALA A O   1 
ATOM   2751 C CB  . ALA A 1 572 ? 182.264 155.074 147.423 1.00 38.01  ? 572 ALA A CB  1 
ATOM   2752 N N   . TRP A 1 573 ? 183.473 152.192 146.411 1.00 42.06  ? 573 TRP A N   1 
ATOM   2753 C CA  . TRP A 1 573 ? 183.378 150.742 146.310 1.00 43.37  ? 573 TRP A CA  1 
ATOM   2754 C C   . TRP A 1 573 ? 184.550 150.076 147.015 1.00 41.37  ? 573 TRP A C   1 
ATOM   2755 O O   . TRP A 1 573 ? 184.364 149.155 147.818 1.00 42.65  ? 573 TRP A O   1 
ATOM   2756 C CB  . TRP A 1 573 ? 183.322 150.326 144.840 1.00 39.62  ? 573 TRP A CB  1 
ATOM   2757 C CG  . TRP A 1 573 ? 183.692 148.898 144.593 1.00 43.26  ? 573 TRP A CG  1 
ATOM   2758 C CD1 . TRP A 1 573 ? 182.910 147.799 144.798 1.00 45.19  ? 573 TRP A CD1 1 
ATOM   2759 C CD2 . TRP A 1 573 ? 184.936 148.414 144.080 1.00 43.54  ? 573 TRP A CD2 1 
ATOM   2760 N NE1 . TRP A 1 573 ? 183.594 146.660 144.450 1.00 43.48  ? 573 TRP A NE1 1 
ATOM   2761 C CE2 . TRP A 1 573 ? 184.841 147.012 144.006 1.00 44.91  ? 573 TRP A CE2 1 
ATOM   2762 C CE3 . TRP A 1 573 ? 186.124 149.031 143.679 1.00 39.46  ? 573 TRP A CE3 1 
ATOM   2763 C CZ2 . TRP A 1 573 ? 185.887 146.218 143.546 1.00 42.74  ? 573 TRP A CZ2 1 
ATOM   2764 C CZ3 . TRP A 1 573 ? 187.161 148.242 143.227 1.00 43.60  ? 573 TRP A CZ3 1 
ATOM   2765 C CH2 . TRP A 1 573 ? 187.037 146.850 143.164 1.00 49.20  ? 573 TRP A CH2 1 
ATOM   2766 N N   . THR A 1 574 ? 185.763 150.568 146.756 1.00 39.67  ? 574 THR A N   1 
ATOM   2767 C CA  . THR A 1 574 ? 186.966 149.905 147.243 1.00 43.37  ? 574 THR A CA  1 
ATOM   2768 C C   . THR A 1 574 ? 186.957 149.794 148.761 1.00 51.42  ? 574 THR A C   1 
ATOM   2769 O O   . THR A 1 574 ? 187.094 148.696 149.317 1.00 55.55  ? 574 THR A O   1 
ATOM   2770 C CB  . THR A 1 574 ? 188.197 150.668 146.759 1.00 47.95  ? 574 THR A CB  1 
ATOM   2771 O OG1 . THR A 1 574 ? 188.304 150.552 145.335 1.00 53.99  ? 574 THR A OG1 1 
ATOM   2772 C CG2 . THR A 1 574 ? 189.443 150.123 147.394 1.00 52.26  ? 574 THR A CG2 1 
ATOM   2773 N N   . ILE A 1 575 ? 186.746 150.917 149.449 1.00 52.99  ? 575 ILE A N   1 
ATOM   2774 C CA  . ILE A 1 575 ? 186.673 150.893 150.906 1.00 46.92  ? 575 ILE A CA  1 
ATOM   2775 C C   . ILE A 1 575 ? 185.560 149.961 151.361 1.00 47.64  ? 575 ILE A C   1 
ATOM   2776 O O   . ILE A 1 575 ? 185.728 149.192 152.316 1.00 55.91  ? 575 ILE A O   1 
ATOM   2777 C CB  . ILE A 1 575 ? 186.490 152.321 151.456 1.00 46.53  ? 575 ILE A CB  1 
ATOM   2778 C CG1 . ILE A 1 575 ? 186.353 152.302 152.979 1.00 59.36  ? 575 ILE A CG1 1 
ATOM   2779 C CG2 . ILE A 1 575 ? 185.301 153.011 150.809 1.00 41.87  ? 575 ILE A CG2 1 
ATOM   2780 C CD1 . ILE A 1 575 ? 187.633 151.945 153.702 1.00 60.87  ? 575 ILE A CD1 1 
ATOM   2781 N N   . GLN A 1 576 ? 184.428 149.974 150.651 1.00 44.87  ? 576 GLN A N   1 
ATOM   2782 C CA  . GLN A 1 576 ? 183.297 149.139 151.039 1.00 48.07  ? 576 GLN A CA  1 
ATOM   2783 C C   . GLN A 1 576 ? 183.675 147.666 151.054 1.00 54.29  ? 576 GLN A C   1 
ATOM   2784 O O   . GLN A 1 576 ? 183.072 146.879 151.792 1.00 56.42  ? 576 GLN A O   1 
ATOM   2785 C CB  . GLN A 1 576 ? 182.119 149.390 150.097 1.00 49.14  ? 576 GLN A CB  1 
ATOM   2786 C CG  . GLN A 1 576 ? 180.845 148.646 150.460 1.00 52.51  ? 576 GLN A CG  1 
ATOM   2787 C CD  . GLN A 1 576 ? 180.666 147.377 149.658 1.00 57.19  ? 576 GLN A CD  1 
ATOM   2788 O OE1 . GLN A 1 576 ? 180.749 147.388 148.431 1.00 58.17  ? 576 GLN A OE1 1 
ATOM   2789 N NE2 . GLN A 1 576 ? 180.422 146.271 150.349 1.00 59.05  ? 576 GLN A NE2 1 
ATOM   2790 N N   . ILE A 1 577 ? 184.675 147.275 150.264 1.00 58.47  ? 577 ILE A N   1 
ATOM   2791 C CA  . ILE A 1 577 ? 185.155 145.900 150.328 1.00 57.31  ? 577 ILE A CA  1 
ATOM   2792 C C   . ILE A 1 577 ? 185.939 145.675 151.613 1.00 62.96  ? 577 ILE A C   1 
ATOM   2793 O O   . ILE A 1 577 ? 185.635 144.765 152.394 1.00 70.90  ? 577 ILE A O   1 
ATOM   2794 C CB  . ILE A 1 577 ? 185.999 145.567 149.086 1.00 54.12  ? 577 ILE A CB  1 
ATOM   2795 C CG1 . ILE A 1 577 ? 185.105 145.416 147.859 1.00 50.46  ? 577 ILE A CG1 1 
ATOM   2796 C CG2 . ILE A 1 577 ? 186.808 144.306 149.317 1.00 60.95  ? 577 ILE A CG2 1 
ATOM   2797 C CD1 . ILE A 1 577 ? 185.816 144.826 146.675 1.00 51.82  ? 577 ILE A CD1 1 
ATOM   2798 N N   . SER A 1 578 ? 186.928 146.534 151.875 1.00 56.21  ? 578 SER A N   1 
ATOM   2799 C CA  . SER A 1 578 ? 187.840 146.298 152.989 1.00 55.55  ? 578 SER A CA  1 
ATOM   2800 C C   . SER A 1 578 ? 187.100 146.300 154.317 1.00 68.25  ? 578 SER A C   1 
ATOM   2801 O O   . SER A 1 578 ? 187.432 145.528 155.224 1.00 76.56  ? 578 SER A O   1 
ATOM   2802 C CB  . SER A 1 578 ? 188.944 147.351 152.988 1.00 64.79  ? 578 SER A CB  1 
ATOM   2803 O OG  . SER A 1 578 ? 189.608 147.383 151.738 1.00 68.84  ? 578 SER A OG  1 
ATOM   2804 N N   . ILE A 1 579 ? 186.093 147.162 154.450 1.00 68.72  ? 579 ILE A N   1 
ATOM   2805 C CA  . ILE A 1 579 ? 185.288 147.183 155.664 1.00 67.93  ? 579 ILE A CA  1 
ATOM   2806 C C   . ILE A 1 579 ? 184.501 145.888 155.809 1.00 67.92  ? 579 ILE A C   1 
ATOM   2807 O O   . ILE A 1 579 ? 184.405 145.324 156.906 1.00 77.33  ? 579 ILE A O   1 
ATOM   2808 C CB  . ILE A 1 579 ? 184.361 148.411 155.660 1.00 63.53  ? 579 ILE A CB  1 
ATOM   2809 C CG1 . ILE A 1 579 ? 185.170 149.689 155.450 1.00 59.61  ? 579 ILE A CG1 1 
ATOM   2810 C CG2 . ILE A 1 579 ? 183.577 148.486 156.953 1.00 74.89  ? 579 ILE A CG2 1 
ATOM   2811 C CD1 . ILE A 1 579 ? 186.274 149.878 156.456 1.00 71.94  ? 579 ILE A CD1 1 
ATOM   2812 N N   . THR A 1 580 ? 183.925 145.393 154.712 1.00 65.12  ? 580 THR A N   1 
ATOM   2813 C CA  . THR A 1 580 ? 182.993 144.274 154.816 1.00 69.18  ? 580 THR A CA  1 
ATOM   2814 C C   . THR A 1 580 ? 183.719 142.959 155.071 1.00 76.99  ? 580 THR A C   1 
ATOM   2815 O O   . THR A 1 580 ? 183.266 142.141 155.881 1.00 82.33  ? 580 THR A O   1 
ATOM   2816 C CB  . THR A 1 580 ? 182.142 144.184 153.550 1.00 68.23  ? 580 THR A CB  1 
ATOM   2817 O OG1 . THR A 1 580 ? 181.409 145.403 153.380 1.00 65.19  ? 580 THR A OG1 1 
ATOM   2818 C CG2 . THR A 1 580 ? 181.161 143.027 153.643 1.00 71.76  ? 580 THR A CG2 1 
ATOM   2819 N N   . SER A 1 581 ? 184.844 142.738 154.398 1.00 78.36  ? 581 SER A N   1 
ATOM   2820 C CA  . SER A 1 581 ? 185.552 141.467 154.486 1.00 83.32  ? 581 SER A CA  1 
ATOM   2821 C C   . SER A 1 581 ? 186.435 141.351 155.720 1.00 86.16  ? 581 SER A C   1 
ATOM   2822 O O   . SER A 1 581 ? 186.984 140.272 155.966 1.00 85.12  ? 581 SER A O   1 
ATOM   2823 C CB  . SER A 1 581 ? 186.402 141.256 153.231 1.00 76.71  ? 581 SER A CB  1 
ATOM   2824 O OG  . SER A 1 581 ? 187.342 142.301 153.071 1.00 74.10  ? 581 SER A OG  1 
ATOM   2825 N N   . THR A 1 582 ? 186.592 142.420 156.495 1.00 83.59  ? 582 THR A N   1 
ATOM   2826 C CA  . THR A 1 582 ? 187.485 142.415 157.645 1.00 87.62  ? 582 THR A CA  1 
ATOM   2827 C C   . THR A 1 582 ? 186.773 143.085 158.816 1.00 92.46  ? 582 THR A C   1 
ATOM   2828 O O   . THR A 1 582 ? 185.570 143.358 158.767 1.00 93.54  ? 582 THR A O   1 
ATOM   2829 C CB  . THR A 1 582 ? 188.808 143.119 157.314 1.00 87.27  ? 582 THR A CB  1 
ATOM   2830 O OG1 . THR A 1 582 ? 188.541 144.459 156.884 1.00 83.55  ? 582 THR A OG1 1 
ATOM   2831 C CG2 . THR A 1 582 ? 189.555 142.381 156.215 1.00 83.32  ? 582 THR A CG2 1 
ATOM   2832 N N   . THR A 1 583 ? 187.529 143.345 159.878 1.00 96.52  ? 583 THR A N   1 
ATOM   2833 C CA  . THR A 1 583 ? 187.068 144.096 161.038 1.00 99.18  ? 583 THR A CA  1 
ATOM   2834 C C   . THR A 1 583 ? 187.842 145.401 161.154 1.00 102.63 ? 583 THR A C   1 
ATOM   2835 O O   . THR A 1 583 ? 188.273 145.801 162.237 1.00 107.30 ? 583 THR A O   1 
ATOM   2836 C CB  . THR A 1 583 ? 187.204 143.276 162.319 1.00 102.59 ? 583 THR A CB  1 
ATOM   2837 O OG1 . THR A 1 583 ? 188.578 142.926 162.520 1.00 103.06 ? 583 THR A OG1 1 
ATOM   2838 C CG2 . THR A 1 583 ? 186.369 142.007 162.231 1.00 101.71 ? 583 THR A CG2 1 
ATOM   2839 N N   . LEU A 1 584 ? 188.033 146.071 160.014 1.00 100.28 ? 584 LEU A N   1 
ATOM   2840 C CA  . LEU A 1 584 ? 188.848 147.281 159.977 1.00 101.88 ? 584 LEU A CA  1 
ATOM   2841 C C   . LEU A 1 584 ? 188.266 148.371 160.868 1.00 103.12 ? 584 LEU A C   1 
ATOM   2842 O O   . LEU A 1 584 ? 189.010 149.121 161.511 1.00 102.43 ? 584 LEU A O   1 
ATOM   2843 C CB  . LEU A 1 584 ? 188.978 147.771 158.535 1.00 96.36  ? 584 LEU A CB  1 
ATOM   2844 C CG  . LEU A 1 584 ? 189.913 148.950 158.267 1.00 97.42  ? 584 LEU A CG  1 
ATOM   2845 C CD1 . LEU A 1 584 ? 191.325 148.617 158.705 1.00 101.29 ? 584 LEU A CD1 1 
ATOM   2846 C CD2 . LEU A 1 584 ? 189.885 149.326 156.796 1.00 81.68  ? 584 LEU A CD2 1 
ATOM   2847 N N   . LEU A 1 585 ? 186.938 148.474 160.922 1.00 103.67 ? 585 LEU A N   1 
ATOM   2848 C CA  . LEU A 1 585 ? 186.243 149.447 161.763 1.00 104.83 ? 585 LEU A CA  1 
ATOM   2849 C C   . LEU A 1 585 ? 185.267 148.697 162.658 1.00 108.04 ? 585 LEU A C   1 
ATOM   2850 O O   . LEU A 1 585 ? 184.099 148.497 162.287 1.00 107.83 ? 585 LEU A O   1 
ATOM   2851 C CB  . LEU A 1 585 ? 185.522 150.492 160.914 1.00 100.51 ? 585 LEU A CB  1 
ATOM   2852 C CG  . LEU A 1 585 ? 186.378 151.258 159.903 1.00 99.10  ? 585 LEU A CG  1 
ATOM   2853 C CD1 . LEU A 1 585 ? 185.540 152.276 159.151 1.00 93.04  ? 585 LEU A CD1 1 
ATOM   2854 C CD2 . LEU A 1 585 ? 187.550 151.934 160.590 1.00 101.70 ? 585 LEU A CD2 1 
ATOM   2855 N N   . PRO A 1 586 ? 185.704 148.243 163.838 1.00 112.56 ? 586 PRO A N   1 
ATOM   2856 C CA  . PRO A 1 586 ? 184.764 147.567 164.749 1.00 117.69 ? 586 PRO A CA  1 
ATOM   2857 C C   . PRO A 1 586 ? 183.564 148.424 165.104 1.00 116.21 ? 586 PRO A C   1 
ATOM   2858 O O   . PRO A 1 586 ? 182.440 147.912 165.186 1.00 108.70 ? 586 PRO A O   1 
ATOM   2859 C CB  . PRO A 1 586 ? 185.633 147.259 165.977 1.00 120.56 ? 586 PRO A CB  1 
ATOM   2860 C CG  . PRO A 1 586 ? 187.031 147.223 165.450 1.00 117.56 ? 586 PRO A CG  1 
ATOM   2861 C CD  . PRO A 1 586 ? 187.079 148.256 164.365 1.00 112.01 ? 586 PRO A CD  1 
ATOM   2862 N N   . HIS A 1 587 ? 183.772 149.719 165.311 1.00 120.97 ? 587 HIS A N   1 
ATOM   2863 C CA  . HIS A 1 587 ? 182.678 150.669 165.414 1.00 120.86 ? 587 HIS A CA  1 
ATOM   2864 C C   . HIS A 1 587 ? 182.296 151.146 164.020 1.00 114.92 ? 587 HIS A C   1 
ATOM   2865 O O   . HIS A 1 587 ? 183.130 151.184 163.110 1.00 113.80 ? 587 HIS A O   1 
ATOM   2866 C CB  . HIS A 1 587 ? 183.064 151.862 166.290 1.00 120.61 ? 587 HIS A CB  1 
ATOM   2867 C CG  . HIS A 1 587 ? 183.318 151.503 167.721 1.00 126.05 ? 587 HIS A CG  1 
ATOM   2868 N ND1 . HIS A 1 587 ? 182.303 151.337 168.638 1.00 125.67 ? 587 HIS A ND1 1 
ATOM   2869 C CD2 . HIS A 1 587 ? 184.472 151.285 168.394 1.00 127.01 ? 587 HIS A CD2 1 
ATOM   2870 C CE1 . HIS A 1 587 ? 182.820 151.029 169.814 1.00 130.59 ? 587 HIS A CE1 1 
ATOM   2871 N NE2 . HIS A 1 587 ? 184.135 150.991 169.693 1.00 130.65 ? 587 HIS A NE2 1 
ATOM   2872 N N   . SER A 1 588 ? 181.028 151.506 163.861 1.00 108.06 ? 588 SER A N   1 
ATOM   2873 C CA  . SER A 1 588 ? 180.477 151.893 162.552 1.00 103.38 ? 588 SER A CA  1 
ATOM   2874 C C   . SER A 1 588 ? 180.702 150.709 161.607 1.00 103.33 ? 588 SER A C   1 
ATOM   2875 O O   . SER A 1 588 ? 180.521 149.551 162.016 1.00 102.88 ? 588 SER A O   1 
ATOM   2876 C CB  . SER A 1 588 ? 181.078 153.206 162.096 1.00 99.96  ? 588 SER A CB  1 
ATOM   2877 O OG  . SER A 1 588 ? 180.685 153.508 160.769 1.00 95.40  ? 588 SER A OG  1 
ATOM   2878 N N   . GLY A 1 589 ? 181.092 150.946 160.363 1.00 95.44  ? 589 GLY A N   1 
ATOM   2879 C CA  . GLY A 1 589 ? 181.334 149.841 159.438 1.00 90.51  ? 589 GLY A CA  1 
ATOM   2880 C C   . GLY A 1 589 ? 180.092 149.204 158.865 1.00 85.40  ? 589 GLY A C   1 
ATOM   2881 O O   . GLY A 1 589 ? 179.951 149.113 157.642 1.00 83.20  ? 589 GLY A O   1 
ATOM   2882 N N   . ASP A 1 590 ? 179.179 148.747 159.726 1.00 86.21  ? 590 ASP A N   1 
ATOM   2883 C CA  . ASP A 1 590 ? 177.898 148.247 159.243 1.00 83.45  ? 590 ASP A CA  1 
ATOM   2884 C C   . ASP A 1 590 ? 177.107 149.349 158.552 1.00 77.28  ? 590 ASP A C   1 
ATOM   2885 O O   . ASP A 1 590 ? 176.480 149.115 157.513 1.00 78.19  ? 590 ASP A O   1 
ATOM   2886 C CB  . ASP A 1 590 ? 177.096 147.647 160.397 1.00 83.88  ? 590 ASP A CB  1 
ATOM   2887 C CG  . ASP A 1 590 ? 177.537 146.236 160.740 1.00 89.32  ? 590 ASP A CG  1 
ATOM   2888 O OD1 . ASP A 1 590 ? 177.841 145.465 159.806 1.00 84.62  ? 590 ASP A OD1 1 
ATOM   2889 O OD2 . ASP A 1 590 ? 177.579 145.898 161.942 1.00 89.97  ? 590 ASP A OD2 1 
ATOM   2890 N N   . ILE A 1 591 ? 177.129 150.561 159.112 1.00 73.65  ? 591 ILE A N   1 
ATOM   2891 C CA  . ILE A 1 591 ? 176.487 151.695 158.454 1.00 71.79  ? 591 ILE A CA  1 
ATOM   2892 C C   . ILE A 1 591 ? 177.158 151.978 157.117 1.00 70.77  ? 591 ILE A C   1 
ATOM   2893 O O   . ILE A 1 591 ? 176.488 152.222 156.106 1.00 70.82  ? 591 ILE A O   1 
ATOM   2894 C CB  . ILE A 1 591 ? 176.511 152.937 159.365 1.00 70.33  ? 591 ILE A CB  1 
ATOM   2895 C CG1 . ILE A 1 591 ? 175.825 152.655 160.702 1.00 77.65  ? 591 ILE A CG1 1 
ATOM   2896 C CG2 . ILE A 1 591 ? 175.844 154.112 158.677 1.00 54.58  ? 591 ILE A CG2 1 
ATOM   2897 C CD1 . ILE A 1 591 ? 176.774 152.263 161.819 1.00 82.84  ? 591 ILE A CD1 1 
ATOM   2898 N N   . ILE A 1 592 ? 178.492 151.945 157.091 1.00 73.12  ? 592 ILE A N   1 
ATOM   2899 C CA  . ILE A 1 592 ? 179.227 152.261 155.869 1.00 73.86  ? 592 ILE A CA  1 
ATOM   2900 C C   . ILE A 1 592 ? 178.898 151.257 154.772 1.00 66.79  ? 592 ILE A C   1 
ATOM   2901 O O   . ILE A 1 592 ? 178.619 151.631 153.628 1.00 64.68  ? 592 ILE A O   1 
ATOM   2902 C CB  . ILE A 1 592 ? 180.739 152.315 156.155 1.00 77.77  ? 592 ILE A CB  1 
ATOM   2903 C CG1 . ILE A 1 592 ? 181.075 153.534 157.015 1.00 78.66  ? 592 ILE A CG1 1 
ATOM   2904 C CG2 . ILE A 1 592 ? 181.531 152.332 154.861 1.00 65.94  ? 592 ILE A CG2 1 
ATOM   2905 C CD1 . ILE A 1 592 ? 182.551 153.687 157.301 1.00 84.72  ? 592 ILE A CD1 1 
ATOM   2906 N N   . ALA A 1 593 ? 178.923 149.965 155.106 1.00 64.13  ? 593 ALA A N   1 
ATOM   2907 C CA  . ALA A 1 593 ? 178.603 148.941 154.117 1.00 61.66  ? 593 ALA A CA  1 
ATOM   2908 C C   . ALA A 1 593 ? 177.150 149.044 153.670 1.00 62.00  ? 593 ALA A C   1 
ATOM   2909 O O   . ALA A 1 593 ? 176.849 148.967 152.472 1.00 63.35  ? 593 ALA A O   1 
ATOM   2910 C CB  . ALA A 1 593 ? 178.895 147.554 154.689 1.00 54.16  ? 593 ALA A CB  1 
ATOM   2911 N N   . THR A 1 594 ? 176.234 149.226 154.624 1.00 60.26  ? 594 THR A N   1 
ATOM   2912 C CA  . THR A 1 594 ? 174.813 149.303 154.310 1.00 58.44  ? 594 THR A CA  1 
ATOM   2913 C C   . THR A 1 594 ? 174.475 150.512 153.450 1.00 55.53  ? 594 THR A C   1 
ATOM   2914 O O   . THR A 1 594 ? 173.502 150.463 152.692 1.00 57.77  ? 594 THR A O   1 
ATOM   2915 C CB  . THR A 1 594 ? 173.997 149.340 155.604 1.00 65.66  ? 594 THR A CB  1 
ATOM   2916 O OG1 . THR A 1 594 ? 174.471 148.324 156.495 1.00 78.96  ? 594 THR A OG1 1 
ATOM   2917 C CG2 . THR A 1 594 ? 172.525 149.097 155.320 1.00 62.45  ? 594 THR A CG2 1 
ATOM   2918 N N   . VAL A 1 595 ? 175.250 151.588 153.546 1.00 54.03  ? 595 VAL A N   1 
ATOM   2919 C CA  . VAL A 1 595 ? 175.021 152.751 152.697 1.00 53.75  ? 595 VAL A CA  1 
ATOM   2920 C C   . VAL A 1 595 ? 175.707 152.600 151.345 1.00 55.77  ? 595 VAL A C   1 
ATOM   2921 O O   . VAL A 1 595 ? 175.136 152.958 150.312 1.00 51.83  ? 595 VAL A O   1 
ATOM   2922 C CB  . VAL A 1 595 ? 175.480 154.030 153.426 1.00 52.62  ? 595 VAL A CB  1 
ATOM   2923 C CG1 . VAL A 1 595 ? 175.480 155.216 152.478 1.00 48.36  ? 595 VAL A CG1 1 
ATOM   2924 C CG2 . VAL A 1 595 ? 174.582 154.307 154.618 1.00 53.25  ? 595 VAL A CG2 1 
ATOM   2925 N N   . PHE A 1 596 ? 176.929 152.065 151.319 1.00 55.95  ? 596 PHE A N   1 
ATOM   2926 C CA  . PHE A 1 596 ? 177.695 152.016 150.080 1.00 46.29  ? 596 PHE A CA  1 
ATOM   2927 C C   . PHE A 1 596 ? 177.241 150.906 149.142 1.00 48.12  ? 596 PHE A C   1 
ATOM   2928 O O   . PHE A 1 596 ? 177.420 151.031 147.926 1.00 47.49  ? 596 PHE A O   1 
ATOM   2929 C CB  . PHE A 1 596 ? 179.184 151.858 150.387 1.00 51.13  ? 596 PHE A CB  1 
ATOM   2930 C CG  . PHE A 1 596 ? 179.836 153.110 150.899 1.00 57.78  ? 596 PHE A CG  1 
ATOM   2931 C CD1 . PHE A 1 596 ? 179.174 154.324 150.848 1.00 56.55  ? 596 PHE A CD1 1 
ATOM   2932 C CD2 . PHE A 1 596 ? 181.116 153.075 151.421 1.00 57.11  ? 596 PHE A CD2 1 
ATOM   2933 C CE1 . PHE A 1 596 ? 179.774 155.475 151.316 1.00 53.99  ? 596 PHE A CE1 1 
ATOM   2934 C CE2 . PHE A 1 596 ? 181.720 154.223 151.889 1.00 56.17  ? 596 PHE A CE2 1 
ATOM   2935 C CZ  . PHE A 1 596 ? 181.048 155.424 151.837 1.00 56.81  ? 596 PHE A CZ  1 
ATOM   2936 N N   . ALA A 1 597 ? 176.677 149.816 149.666 1.00 48.46  ? 597 ALA A N   1 
ATOM   2937 C CA  . ALA A 1 597 ? 176.253 148.725 148.789 1.00 42.29  ? 597 ALA A CA  1 
ATOM   2938 C C   . ALA A 1 597 ? 175.183 149.151 147.787 1.00 37.69  ? 597 ALA A C   1 
ATOM   2939 O O   . ALA A 1 597 ? 175.338 148.847 146.589 1.00 30.65  ? 597 ALA A O   1 
ATOM   2940 C CB  . ALA A 1 597 ? 175.801 147.533 149.638 1.00 41.86  ? 597 ALA A CB  1 
ATOM   2941 N N   . PRO A 1 598 ? 174.097 149.834 148.179 1.00 36.51  ? 598 PRO A N   1 
ATOM   2942 C CA  . PRO A 1 598 ? 173.184 150.367 147.154 1.00 30.19  ? 598 PRO A CA  1 
ATOM   2943 C C   . PRO A 1 598 ? 173.864 151.336 146.208 1.00 32.00  ? 598 PRO A C   1 
ATOM   2944 O O   . PRO A 1 598 ? 173.532 151.379 145.018 1.00 27.92  ? 598 PRO A O   1 
ATOM   2945 C CB  . PRO A 1 598 ? 172.091 151.052 147.984 1.00 29.98  ? 598 PRO A CB  1 
ATOM   2946 C CG  . PRO A 1 598 ? 172.152 150.400 149.304 1.00 33.83  ? 598 PRO A CG  1 
ATOM   2947 C CD  . PRO A 1 598 ? 173.590 150.104 149.536 1.00 34.16  ? 598 PRO A CD  1 
ATOM   2948 N N   . LEU A 1 599 ? 174.822 152.116 146.710 1.00 33.88  ? 599 LEU A N   1 
ATOM   2949 C CA  . LEU A 1 599 ? 175.579 153.010 145.844 1.00 30.93  ? 599 LEU A CA  1 
ATOM   2950 C C   . LEU A 1 599 ? 176.461 152.238 144.873 1.00 33.98  ? 599 LEU A C   1 
ATOM   2951 O O   . LEU A 1 599 ? 176.639 152.668 143.731 1.00 31.21  ? 599 LEU A O   1 
ATOM   2952 C CB  . LEU A 1 599 ? 176.417 153.967 146.687 1.00 30.70  ? 599 LEU A CB  1 
ATOM   2953 C CG  . LEU A 1 599 ? 175.618 154.981 147.505 1.00 37.78  ? 599 LEU A CG  1 
ATOM   2954 C CD1 . LEU A 1 599 ? 176.535 155.757 148.429 1.00 51.05  ? 599 LEU A CD1 1 
ATOM   2955 C CD2 . LEU A 1 599 ? 174.862 155.922 146.587 1.00 31.18  ? 599 LEU A CD2 1 
ATOM   2956 N N   . GLU A 1 600 ? 177.020 151.103 145.298 1.00 36.14  ? 600 GLU A N   1 
ATOM   2957 C CA  . GLU A 1 600 ? 177.774 150.265 144.371 1.00 32.64  ? 600 GLU A CA  1 
ATOM   2958 C C   . GLU A 1 600 ? 176.872 149.681 143.292 1.00 26.64  ? 600 GLU A C   1 
ATOM   2959 O O   . GLU A 1 600 ? 177.259 149.608 142.118 1.00 22.01  ? 600 GLU A O   1 
ATOM   2960 C CB  . GLU A 1 600 ? 178.496 149.153 145.131 1.00 35.99  ? 600 GLU A CB  1 
ATOM   2961 C CG  . GLU A 1 600 ? 179.057 148.045 144.248 1.00 40.91  ? 600 GLU A CG  1 
ATOM   2962 C CD  . GLU A 1 600 ? 180.026 148.551 143.194 1.00 45.01  ? 600 GLU A CD  1 
ATOM   2963 O OE1 . GLU A 1 600 ? 180.665 149.599 143.415 1.00 46.00  ? 600 GLU A OE1 1 
ATOM   2964 O OE2 . GLU A 1 600 ? 180.151 147.898 142.138 1.00 38.10  ? 600 GLU A OE2 1 
ATOM   2965 N N   . VAL A 1 601 ? 175.666 149.251 143.668 1.00 25.76  ? 601 VAL A N   1 
ATOM   2966 C CA  . VAL A 1 601 ? 174.721 148.763 142.667 1.00 23.11  ? 601 VAL A CA  1 
ATOM   2967 C C   . VAL A 1 601 ? 174.356 149.878 141.693 1.00 27.27  ? 601 VAL A C   1 
ATOM   2968 O O   . VAL A 1 601 ? 174.232 149.652 140.484 1.00 25.73  ? 601 VAL A O   1 
ATOM   2969 C CB  . VAL A 1 601 ? 173.476 148.168 143.350 1.00 19.74  ? 601 VAL A CB  1 
ATOM   2970 C CG1 . VAL A 1 601 ? 172.497 147.656 142.312 1.00 20.16  ? 601 VAL A CG1 1 
ATOM   2971 C CG2 . VAL A 1 601 ? 173.876 147.052 144.289 1.00 24.78  ? 601 VAL A CG2 1 
ATOM   2972 N N   . PHE A 1 602 ? 174.186 151.101 142.202 1.00 28.46  ? 602 PHE A N   1 
ATOM   2973 C CA  . PHE A 1 602 ? 173.903 152.242 141.335 1.00 23.13  ? 602 PHE A CA  1 
ATOM   2974 C C   . PHE A 1 602 ? 175.074 152.539 140.404 1.00 23.90  ? 602 PHE A C   1 
ATOM   2975 O O   . PHE A 1 602 ? 174.878 152.900 139.237 1.00 25.42  ? 602 PHE A O   1 
ATOM   2976 C CB  . PHE A 1 602 ? 173.565 153.465 142.188 1.00 22.84  ? 602 PHE A CB  1 
ATOM   2977 C CG  . PHE A 1 602 ? 173.180 154.675 141.391 1.00 23.96  ? 602 PHE A CG  1 
ATOM   2978 C CD1 . PHE A 1 602 ? 171.895 154.816 140.903 1.00 24.28  ? 602 PHE A CD1 1 
ATOM   2979 C CD2 . PHE A 1 602 ? 174.101 155.675 141.137 1.00 24.34  ? 602 PHE A CD2 1 
ATOM   2980 C CE1 . PHE A 1 602 ? 171.537 155.926 140.171 1.00 29.97  ? 602 PHE A CE1 1 
ATOM   2981 C CE2 . PHE A 1 602 ? 173.749 156.788 140.404 1.00 27.34  ? 602 PHE A CE2 1 
ATOM   2982 C CZ  . PHE A 1 602 ? 172.465 156.915 139.922 1.00 34.10  ? 602 PHE A CZ  1 
ATOM   2983 N N   . ARG A 1 603 ? 176.302 152.410 140.909 1.00 24.35  ? 603 ARG A N   1 
ATOM   2984 C CA  . ARG A 1 603 ? 177.475 152.612 140.066 1.00 21.86  ? 603 ARG A CA  1 
ATOM   2985 C C   . ARG A 1 603 ? 177.533 151.577 138.953 1.00 23.01  ? 603 ARG A C   1 
ATOM   2986 O O   . ARG A 1 603 ? 177.849 151.908 137.808 1.00 25.41  ? 603 ARG A O   1 
ATOM   2987 C CB  . ARG A 1 603 ? 178.750 152.559 140.904 1.00 25.52  ? 603 ARG A CB  1 
ATOM   2988 C CG  . ARG A 1 603 ? 179.984 153.021 140.153 1.00 24.54  ? 603 ARG A CG  1 
ATOM   2989 C CD  . ARG A 1 603 ? 181.253 152.422 140.726 1.00 26.50  ? 603 ARG A CD  1 
ATOM   2990 N NE  . ARG A 1 603 ? 181.297 150.976 140.547 1.00 29.34  ? 603 ARG A NE  1 
ATOM   2991 C CZ  . ARG A 1 603 ? 181.604 150.372 139.407 1.00 33.06  ? 603 ARG A CZ  1 
ATOM   2992 N NH1 . ARG A 1 603 ? 181.898 151.060 138.318 1.00 33.77  ? 603 ARG A NH1 1 
ATOM   2993 N NH2 . ARG A 1 603 ? 181.612 149.044 139.359 1.00 30.54  ? 603 ARG A NH2 1 
ATOM   2994 N N   . ARG A 1 604 ? 177.239 150.315 139.274 1.00 24.66  ? 604 ARG A N   1 
ATOM   2995 C CA  . ARG A 1 604 ? 177.184 149.282 138.242 1.00 20.88  ? 604 ARG A CA  1 
ATOM   2996 C C   . ARG A 1 604 ? 176.075 149.566 137.236 1.00 22.74  ? 604 ARG A C   1 
ATOM   2997 O O   . ARG A 1 604 ? 176.233 149.320 136.034 1.00 26.05  ? 604 ARG A O   1 
ATOM   2998 C CB  . ARG A 1 604 ? 176.988 147.912 138.887 1.00 22.11  ? 604 ARG A CB  1 
ATOM   2999 C CG  . ARG A 1 604 ? 176.926 146.751 137.906 1.00 24.95  ? 604 ARG A CG  1 
ATOM   3000 C CD  . ARG A 1 604 ? 178.216 146.603 137.121 1.00 26.31  ? 604 ARG A CD  1 
ATOM   3001 N NE  . ARG A 1 604 ? 179.359 146.355 137.989 1.00 25.52  ? 604 ARG A NE  1 
ATOM   3002 C CZ  . ARG A 1 604 ? 180.599 146.177 137.558 1.00 25.79  ? 604 ARG A CZ  1 
ATOM   3003 N NH1 . ARG A 1 604 ? 180.892 146.209 136.271 1.00 28.11  ? 604 ARG A NH1 1 
ATOM   3004 N NH2 . ARG A 1 604 ? 181.568 145.961 138.441 1.00 28.24  ? 604 ARG A NH2 1 
ATOM   3005 N N   . PHE A 1 605 ? 174.940 150.079 137.712 1.00 21.97  ? 605 PHE A N   1 
ATOM   3006 C CA  . PHE A 1 605 ? 173.847 150.454 136.821 1.00 16.88  ? 605 PHE A CA  1 
ATOM   3007 C C   . PHE A 1 605 ? 174.274 151.546 135.847 1.00 18.62  ? 605 PHE A C   1 
ATOM   3008 O O   . PHE A 1 605 ? 173.946 151.488 134.657 1.00 17.11  ? 605 PHE A O   1 
ATOM   3009 C CB  . PHE A 1 605 ? 172.643 150.886 137.662 1.00 14.85  ? 605 PHE A CB  1 
ATOM   3010 C CG  . PHE A 1 605 ? 171.770 151.924 137.018 1.00 16.08  ? 605 PHE A CG  1 
ATOM   3011 C CD1 . PHE A 1 605 ? 170.859 151.578 136.040 1.00 14.60  ? 605 PHE A CD1 1 
ATOM   3012 C CD2 . PHE A 1 605 ? 171.828 153.242 137.431 1.00 15.23  ? 605 PHE A CD2 1 
ATOM   3013 C CE1 . PHE A 1 605 ? 170.048 152.529 135.466 1.00 12.93  ? 605 PHE A CE1 1 
ATOM   3014 C CE2 . PHE A 1 605 ? 171.020 154.196 136.858 1.00 15.62  ? 605 PHE A CE2 1 
ATOM   3015 C CZ  . PHE A 1 605 ? 170.128 153.838 135.876 1.00 13.11  ? 605 PHE A CZ  1 
ATOM   3016 N N   . VAL A 1 606 ? 175.011 152.546 136.332 1.00 22.04  ? 606 VAL A N   1 
ATOM   3017 C CA  . VAL A 1 606 ? 175.516 153.595 135.448 1.00 21.78  ? 606 VAL A CA  1 
ATOM   3018 C C   . VAL A 1 606 ? 176.576 153.036 134.503 1.00 28.55  ? 606 VAL A C   1 
ATOM   3019 O O   . VAL A 1 606 ? 176.650 153.424 133.331 1.00 31.32  ? 606 VAL A O   1 
ATOM   3020 C CB  . VAL A 1 606 ? 176.059 154.776 136.273 1.00 20.13  ? 606 VAL A CB  1 
ATOM   3021 C CG1 . VAL A 1 606 ? 176.628 155.846 135.360 1.00 25.01  ? 606 VAL A CG1 1 
ATOM   3022 C CG2 . VAL A 1 606 ? 174.967 155.355 137.151 1.00 19.17  ? 606 VAL A CG2 1 
ATOM   3023 N N   . TRP A 1 607 ? 177.411 152.122 134.999 1.00 27.82  ? 607 TRP A N   1 
ATOM   3024 C CA  . TRP A 1 607 ? 178.456 151.512 134.184 1.00 23.56  ? 607 TRP A CA  1 
ATOM   3025 C C   . TRP A 1 607 ? 177.874 150.705 133.034 1.00 26.01  ? 607 TRP A C   1 
ATOM   3026 O O   . TRP A 1 607 ? 178.480 150.638 131.958 1.00 30.00  ? 607 TRP A O   1 
ATOM   3027 C CB  . TRP A 1 607 ? 179.332 150.626 135.072 1.00 25.07  ? 607 TRP A CB  1 
ATOM   3028 C CG  . TRP A 1 607 ? 180.375 149.810 134.361 1.00 32.43  ? 607 TRP A CG  1 
ATOM   3029 C CD1 . TRP A 1 607 ? 181.662 150.173 134.100 1.00 32.35  ? 607 TRP A CD1 1 
ATOM   3030 C CD2 . TRP A 1 607 ? 180.225 148.478 133.854 1.00 31.34  ? 607 TRP A CD2 1 
ATOM   3031 N NE1 . TRP A 1 607 ? 182.318 149.159 133.452 1.00 29.68  ? 607 TRP A NE1 1 
ATOM   3032 C CE2 . TRP A 1 607 ? 181.458 148.106 133.289 1.00 31.73  ? 607 TRP A CE2 1 
ATOM   3033 C CE3 . TRP A 1 607 ? 179.167 147.567 133.818 1.00 26.29  ? 607 TRP A CE3 1 
ATOM   3034 C CZ2 . TRP A 1 607 ? 181.659 146.865 132.696 1.00 29.83  ? 607 TRP A CZ2 1 
ATOM   3035 C CZ3 . TRP A 1 607 ? 179.370 146.338 133.229 1.00 20.91  ? 607 TRP A CZ3 1 
ATOM   3036 C CH2 . TRP A 1 607 ? 180.605 145.997 132.677 1.00 24.12  ? 607 TRP A CH2 1 
ATOM   3037 N N   . ASN A 1 608 ? 176.723 150.067 133.254 1.00 25.39  ? 608 ASN A N   1 
ATOM   3038 C CA  . ASN A 1 608 ? 176.125 149.226 132.222 1.00 24.32  ? 608 ASN A CA  1 
ATOM   3039 C C   . ASN A 1 608 ? 175.790 150.027 130.973 1.00 25.14  ? 608 ASN A C   1 
ATOM   3040 O O   . ASN A 1 608 ? 176.039 149.568 129.851 1.00 28.79  ? 608 ASN A O   1 
ATOM   3041 C CB  . ASN A 1 608 ? 174.874 148.539 132.764 1.00 20.02  ? 608 ASN A CB  1 
ATOM   3042 C CG  . ASN A 1 608 ? 175.193 147.445 133.755 1.00 22.63  ? 608 ASN A CG  1 
ATOM   3043 O OD1 . ASN A 1 608 ? 176.183 146.736 133.611 1.00 31.92  ? 608 ASN A OD1 1 
ATOM   3044 N ND2 . ASN A 1 608 ? 174.351 147.298 134.768 1.00 22.90  ? 608 ASN A ND2 1 
ATOM   3045 N N   . PHE A 1 609 ? 175.234 151.230 131.145 1.00 22.63  ? 609 PHE A N   1 
ATOM   3046 C CA  . PHE A 1 609 ? 174.845 152.045 129.998 1.00 22.58  ? 609 PHE A CA  1 
ATOM   3047 C C   . PHE A 1 609 ? 176.013 152.251 129.050 1.00 30.71  ? 609 PHE A C   1 
ATOM   3048 O O   . PHE A 1 609 ? 175.927 151.940 127.857 1.00 36.17  ? 609 PHE A O   1 
ATOM   3049 C CB  . PHE A 1 609 ? 174.319 153.403 130.465 1.00 18.02  ? 609 PHE A CB  1 
ATOM   3050 C CG  . PHE A 1 609 ? 172.883 153.395 130.881 1.00 19.49  ? 609 PHE A CG  1 
ATOM   3051 C CD1 . PHE A 1 609 ? 171.895 153.011 129.997 1.00 21.63  ? 609 PHE A CD1 1 
ATOM   3052 C CD2 . PHE A 1 609 ? 172.517 153.801 132.149 1.00 17.36  ? 609 PHE A CD2 1 
ATOM   3053 C CE1 . PHE A 1 609 ? 170.574 153.012 130.376 1.00 21.12  ? 609 PHE A CE1 1 
ATOM   3054 C CE2 . PHE A 1 609 ? 171.197 153.806 132.531 1.00 11.56  ? 609 PHE A CE2 1 
ATOM   3055 C CZ  . PHE A 1 609 ? 170.225 153.411 131.644 1.00 15.89  ? 609 PHE A CZ  1 
ATOM   3056 N N   . PHE A 1 610 ? 177.135 152.732 129.574 1.00 31.76  ? 610 PHE A N   1 
ATOM   3057 C CA  . PHE A 1 610 ? 178.248 153.101 128.715 1.00 28.89  ? 610 PHE A CA  1 
ATOM   3058 C C   . PHE A 1 610 ? 179.108 151.911 128.321 1.00 30.44  ? 610 PHE A C   1 
ATOM   3059 O O   . PHE A 1 610 ? 179.699 151.937 127.239 1.00 34.81  ? 610 PHE A O   1 
ATOM   3060 C CB  . PHE A 1 610 ? 179.075 154.184 129.396 1.00 23.24  ? 610 PHE A CB  1 
ATOM   3061 C CG  . PHE A 1 610 ? 178.253 155.350 129.848 1.00 27.49  ? 610 PHE A CG  1 
ATOM   3062 C CD1 . PHE A 1 610 ? 177.714 156.227 128.927 1.00 25.78  ? 610 PHE A CD1 1 
ATOM   3063 C CD2 . PHE A 1 610 ? 177.989 155.551 131.188 1.00 34.61  ? 610 PHE A CD2 1 
ATOM   3064 C CE1 . PHE A 1 610 ? 176.944 157.290 129.335 1.00 26.83  ? 610 PHE A CE1 1 
ATOM   3065 C CE2 . PHE A 1 610 ? 177.219 156.615 131.599 1.00 32.34  ? 610 PHE A CE2 1 
ATOM   3066 C CZ  . PHE A 1 610 ? 176.697 157.485 130.670 1.00 29.25  ? 610 PHE A CZ  1 
ATOM   3067 N N   . ARG A 1 611 ? 179.157 150.851 129.131 1.00 31.92  ? 611 ARG A N   1 
ATOM   3068 C CA  . ARG A 1 611 ? 179.805 149.630 128.671 1.00 28.14  ? 611 ARG A CA  1 
ATOM   3069 C C   . ARG A 1 611 ? 179.074 149.049 127.472 1.00 33.83  ? 611 ARG A C   1 
ATOM   3070 O O   . ARG A 1 611 ? 179.704 148.661 126.483 1.00 39.84  ? 611 ARG A O   1 
ATOM   3071 C CB  . ARG A 1 611 ? 179.871 148.601 129.795 1.00 27.95  ? 611 ARG A CB  1 
ATOM   3072 C CG  . ARG A 1 611 ? 180.631 147.344 129.415 1.00 27.17  ? 611 ARG A CG  1 
ATOM   3073 C CD  . ARG A 1 611 ? 182.098 147.653 129.213 1.00 28.51  ? 611 ARG A CD  1 
ATOM   3074 N NE  . ARG A 1 611 ? 182.905 146.453 129.034 1.00 28.88  ? 611 ARG A NE  1 
ATOM   3075 C CZ  . ARG A 1 611 ? 183.297 145.984 127.859 1.00 32.18  ? 611 ARG A CZ  1 
ATOM   3076 N NH1 . ARG A 1 611 ? 182.969 146.588 126.730 1.00 41.37  ? 611 ARG A NH1 1 
ATOM   3077 N NH2 . ARG A 1 611 ? 184.041 144.883 127.815 1.00 32.59  ? 611 ARG A NH2 1 
ATOM   3078 N N   . LEU A 1 612 ? 177.741 148.992 127.533 1.00 29.75  ? 612 LEU A N   1 
ATOM   3079 C CA  . LEU A 1 612 ? 176.985 148.489 126.395 1.00 30.29  ? 612 LEU A CA  1 
ATOM   3080 C C   . LEU A 1 612 ? 177.049 149.446 125.212 1.00 36.96  ? 612 LEU A C   1 
ATOM   3081 O O   . LEU A 1 612 ? 177.097 148.997 124.064 1.00 34.47  ? 612 LEU A O   1 
ATOM   3082 C CB  . LEU A 1 612 ? 175.536 148.222 126.799 1.00 27.02  ? 612 LEU A CB  1 
ATOM   3083 C CG  . LEU A 1 612 ? 175.216 146.822 127.330 1.00 25.72  ? 612 LEU A CG  1 
ATOM   3084 C CD1 . LEU A 1 612 ? 175.466 145.777 126.261 1.00 26.39  ? 612 LEU A CD1 1 
ATOM   3085 C CD2 . LEU A 1 612 ? 176.010 146.505 128.589 1.00 26.65  ? 612 LEU A CD2 1 
ATOM   3086 N N   . GLU A 1 613 ? 177.070 150.756 125.465 1.00 36.67  ? 613 GLU A N   1 
ATOM   3087 C CA  . GLU A 1 613 ? 177.219 151.716 124.375 1.00 34.73  ? 613 GLU A CA  1 
ATOM   3088 C C   . GLU A 1 613 ? 178.547 151.529 123.655 1.00 42.00  ? 613 GLU A C   1 
ATOM   3089 O O   . GLU A 1 613 ? 178.609 151.558 122.420 1.00 50.07  ? 613 GLU A O   1 
ATOM   3090 C CB  . GLU A 1 613 ? 177.100 153.139 124.914 1.00 33.87  ? 613 GLU A CB  1 
ATOM   3091 C CG  . GLU A 1 613 ? 177.424 154.206 123.891 1.00 46.53  ? 613 GLU A CG  1 
ATOM   3092 C CD  . GLU A 1 613 ? 177.519 155.585 124.500 1.00 49.66  ? 613 GLU A CD  1 
ATOM   3093 O OE1 . GLU A 1 613 ? 177.667 155.681 125.733 1.00 49.75  ? 613 GLU A OE1 1 
ATOM   3094 O OE2 . GLU A 1 613 ? 177.450 156.576 123.747 1.00 55.54  ? 613 GLU A OE2 1 
ATOM   3095 N N   . ASN A 1 614 ? 179.626 151.340 124.414 1.00 40.76  ? 614 ASN A N   1 
ATOM   3096 C CA  . ASN A 1 614 ? 180.935 151.095 123.829 1.00 36.90  ? 614 ASN A CA  1 
ATOM   3097 C C   . ASN A 1 614 ? 180.936 149.784 123.058 1.00 45.13  ? 614 ASN A C   1 
ATOM   3098 O O   . ASN A 1 614 ? 181.381 149.745 121.911 1.00 53.43  ? 614 ASN A O   1 
ATOM   3099 C CB  . ASN A 1 614 ? 182.017 151.073 124.907 1.00 36.71  ? 614 ASN A CB  1 
ATOM   3100 C CG  . ASN A 1 614 ? 183.413 151.013 124.328 1.00 41.72  ? 614 ASN A CG  1 
ATOM   3101 O OD1 . ASN A 1 614 ? 183.651 151.470 123.211 1.00 45.65  ? 614 ASN A OD1 1 
ATOM   3102 N ND2 . ASN A 1 614 ? 184.343 150.446 125.083 1.00 39.50  ? 614 ASN A ND2 1 
ATOM   3103 N N   . GLU A 1 615 ? 180.428 148.714 123.670 1.00 42.74  ? 615 GLU A N   1 
ATOM   3104 C CA  . GLU A 1 615 ? 180.374 147.405 123.029 1.00 37.63  ? 615 GLU A CA  1 
ATOM   3105 C C   . GLU A 1 615 ? 179.580 147.465 121.732 1.00 45.19  ? 615 GLU A C   1 
ATOM   3106 O O   . GLU A 1 615 ? 179.874 146.739 120.777 1.00 51.14  ? 615 GLU A O   1 
ATOM   3107 C CB  . GLU A 1 615 ? 179.757 146.378 123.976 1.00 39.74  ? 615 GLU A CB  1 
ATOM   3108 C CG  . GLU A 1 615 ? 179.772 144.962 123.444 1.00 50.12  ? 615 GLU A CG  1 
ATOM   3109 C CD  . GLU A 1 615 ? 181.109 144.286 123.644 1.00 56.78  ? 615 GLU A CD  1 
ATOM   3110 O OE1 . GLU A 1 615 ? 181.804 144.631 124.621 1.00 51.98  ? 615 GLU A OE1 1 
ATOM   3111 O OE2 . GLU A 1 615 ? 181.465 143.410 122.827 1.00 55.65  ? 615 GLU A OE2 1 
ATOM   3112 N N   . HIS A 1 616 ? 178.567 148.331 121.693 1.00 45.07  ? 616 HIS A N   1 
ATOM   3113 C CA  . HIS A 1 616 ? 177.762 148.490 120.489 1.00 43.78  ? 616 HIS A CA  1 
ATOM   3114 C C   . HIS A 1 616 ? 178.526 149.249 119.412 1.00 47.27  ? 616 HIS A C   1 
ATOM   3115 O O   . HIS A 1 616 ? 178.675 148.763 118.285 1.00 45.67  ? 616 HIS A O   1 
ATOM   3116 C CB  . HIS A 1 616 ? 176.457 149.204 120.838 1.00 41.46  ? 616 HIS A CB  1 
ATOM   3117 C CG  . HIS A 1 616 ? 175.617 149.547 119.650 1.00 47.86  ? 616 HIS A CG  1 
ATOM   3118 N ND1 . HIS A 1 616 ? 175.043 148.590 118.843 1.00 49.71  ? 616 HIS A ND1 1 
ATOM   3119 C CD2 . HIS A 1 616 ? 175.248 150.744 119.136 1.00 46.94  ? 616 HIS A CD2 1 
ATOM   3120 C CE1 . HIS A 1 616 ? 174.358 149.182 117.881 1.00 49.26  ? 616 HIS A CE1 1 
ATOM   3121 N NE2 . HIS A 1 616 ? 174.466 150.489 118.036 1.00 51.36  ? 616 HIS A NE2 1 
ATOM   3122 N N   . LEU A 1 617 ? 179.016 150.445 119.739 1.00 46.69  ? 617 LEU A N   1 
ATOM   3123 C CA  . LEU A 1 617 ? 179.716 151.269 118.759 1.00 44.27  ? 617 LEU A CA  1 
ATOM   3124 C C   . LEU A 1 617 ? 180.991 150.599 118.263 1.00 48.84  ? 617 LEU A C   1 
ATOM   3125 O O   . LEU A 1 617 ? 181.108 150.268 117.079 1.00 56.52  ? 617 LEU A O   1 
ATOM   3126 C CB  . LEU A 1 617 ? 180.047 152.637 119.353 1.00 47.75  ? 617 LEU A CB  1 
ATOM   3127 C CG  . LEU A 1 617 ? 178.857 153.554 119.617 1.00 54.59  ? 617 LEU A CG  1 
ATOM   3128 C CD1 . LEU A 1 617 ? 179.329 154.874 120.195 1.00 56.17  ? 617 LEU A CD1 1 
ATOM   3129 C CD2 . LEU A 1 617 ? 178.072 153.772 118.337 1.00 56.45  ? 617 LEU A CD2 1 
ATOM   3130 N N   . ASN A 1 618 ? 181.948 150.394 119.163 1.00 48.73  ? 618 ASN A N   1 
ATOM   3131 C CA  . ASN A 1 618 ? 183.208 149.763 118.799 1.00 48.89  ? 618 ASN A CA  1 
ATOM   3132 C C   . ASN A 1 618 ? 183.272 148.366 119.398 1.00 47.02  ? 618 ASN A C   1 
ATOM   3133 O O   . ASN A 1 618 ? 182.873 148.154 120.544 1.00 44.31  ? 618 ASN A O   1 
ATOM   3134 C CB  . ASN A 1 618 ? 184.381 150.602 119.297 1.00 45.15  ? 618 ASN A CB  1 
ATOM   3135 C CG  . ASN A 1 618 ? 184.043 152.072 119.391 1.00 58.34  ? 618 ASN A CG  1 
ATOM   3136 O OD1 . ASN A 1 618 ? 183.283 152.599 118.581 1.00 63.75  ? 618 ASN A OD1 1 
ATOM   3137 N ND2 . ASN A 1 618 ? 184.603 152.744 120.388 1.00 56.49  ? 618 ASN A ND2 1 
ATOM   3138 N N   . ASN A 1 619 ? 183.788 147.408 118.636 1.00 52.38  ? 619 ASN A N   1 
ATOM   3139 C CA  . ASN A 1 619 ? 183.825 146.028 119.115 1.00 53.21  ? 619 ASN A CA  1 
ATOM   3140 C C   . ASN A 1 619 ? 184.915 145.918 120.178 1.00 42.33  ? 619 ASN A C   1 
ATOM   3141 O O   . ASN A 1 619 ? 185.984 145.338 119.973 1.00 34.84  ? 619 ASN A O   1 
ATOM   3142 C CB  . ASN A 1 619 ? 184.056 145.060 117.963 1.00 54.69  ? 619 ASN A CB  1 
ATOM   3143 C CG  . ASN A 1 619 ? 184.016 143.614 118.403 1.00 56.57  ? 619 ASN A CG  1 
ATOM   3144 O OD1 . ASN A 1 619 ? 185.032 142.923 118.397 1.00 63.18  ? 619 ASN A OD1 1 
ATOM   3145 N ND2 . ASN A 1 619 ? 182.838 143.150 118.799 1.00 48.31  ? 619 ASN A ND2 1 
ATOM   3146 N N   . CYS A 1 620 ? 184.637 146.507 121.339 1.00 27.64  ? 620 CYS A N   1 
ATOM   3147 C CA  . CYS A 1 620 ? 185.515 146.366 122.488 1.00 30.67  ? 620 CYS A CA  1 
ATOM   3148 C C   . CYS A 1 620 ? 185.233 145.044 123.185 1.00 34.38  ? 620 CYS A C   1 
ATOM   3149 O O   . CYS A 1 620 ? 184.119 144.518 123.137 1.00 33.84  ? 620 CYS A O   1 
ATOM   3150 C CB  . CYS A 1 620 ? 185.331 147.528 123.463 1.00 37.77  ? 620 CYS A CB  1 
ATOM   3151 S SG  . CYS A 1 620 ? 183.752 147.542 124.331 1.00 54.25  ? 620 CYS A SG  1 
ATOM   3152 N N   . GLY A 1 621 ? 186.261 144.498 123.828 1.00 35.58  ? 621 GLY A N   1 
ATOM   3153 C CA  . GLY A 1 621 ? 186.200 143.160 124.361 1.00 31.56  ? 621 GLY A CA  1 
ATOM   3154 C C   . GLY A 1 621 ? 186.369 142.069 123.326 1.00 31.75  ? 621 GLY A C   1 
ATOM   3155 O O   . GLY A 1 621 ? 186.657 140.926 123.693 1.00 31.79  ? 621 GLY A O   1 
ATOM   3156 N N   . GLU A 1 622 ? 186.199 142.396 122.045 1.00 31.27  ? 622 GLU A N   1 
ATOM   3157 C CA  . GLU A 1 622 ? 186.462 141.474 120.941 1.00 30.47  ? 622 GLU A CA  1 
ATOM   3158 C C   . GLU A 1 622 ? 185.660 140.184 121.082 1.00 31.87  ? 622 GLU A C   1 
ATOM   3159 O O   . GLU A 1 622 ? 186.179 139.079 120.911 1.00 32.05  ? 622 GLU A O   1 
ATOM   3160 C CB  . GLU A 1 622 ? 187.958 141.188 120.820 1.00 30.73  ? 622 GLU A CB  1 
ATOM   3161 C CG  . GLU A 1 622 ? 188.765 142.392 120.357 1.00 33.59  ? 622 GLU A CG  1 
ATOM   3162 C CD  . GLU A 1 622 ? 190.230 142.292 120.725 1.00 40.63  ? 622 GLU A CD  1 
ATOM   3163 O OE1 . GLU A 1 622 ? 190.549 141.597 121.713 1.00 42.39  ? 622 GLU A OE1 1 
ATOM   3164 O OE2 . GLU A 1 622 ? 191.065 142.908 120.029 1.00 42.71  ? 622 GLU A OE2 1 
ATOM   3165 N N   . PHE A 1 623 ? 184.372 140.330 121.400 1.00 30.36  ? 623 PHE A N   1 
ATOM   3166 C CA  . PHE A 1 623 ? 183.426 139.222 121.368 1.00 24.63  ? 623 PHE A CA  1 
ATOM   3167 C C   . PHE A 1 623 ? 182.734 139.093 120.018 1.00 31.34  ? 623 PHE A C   1 
ATOM   3168 O O   . PHE A 1 623 ? 181.844 138.247 119.864 1.00 35.85  ? 623 PHE A O   1 
ATOM   3169 C CB  . PHE A 1 623 ? 182.383 139.377 122.475 1.00 24.59  ? 623 PHE A CB  1 
ATOM   3170 C CG  . PHE A 1 623 ? 182.953 139.343 123.862 1.00 25.34  ? 623 PHE A CG  1 
ATOM   3171 C CD1 . PHE A 1 623 ? 183.424 138.162 124.406 1.00 25.08  ? 623 PHE A CD1 1 
ATOM   3172 C CD2 . PHE A 1 623 ? 182.990 140.488 124.634 1.00 25.21  ? 623 PHE A CD2 1 
ATOM   3173 C CE1 . PHE A 1 623 ? 183.937 138.131 125.684 1.00 22.50  ? 623 PHE A CE1 1 
ATOM   3174 C CE2 . PHE A 1 623 ? 183.502 140.462 125.912 1.00 21.90  ? 623 PHE A CE2 1 
ATOM   3175 C CZ  . PHE A 1 623 ? 183.976 139.283 126.437 1.00 21.39  ? 623 PHE A CZ  1 
ATOM   3176 N N   . ARG A 1 624 ? 183.118 139.917 119.044 1.00 32.92  ? 624 ARG A N   1 
ATOM   3177 C CA  . ARG A 1 624 ? 182.499 139.942 117.719 1.00 33.00  ? 624 ARG A CA  1 
ATOM   3178 C C   . ARG A 1 624 ? 181.000 140.206 117.800 1.00 39.06  ? 624 ARG A C   1 
ATOM   3179 O O   . ARG A 1 624 ? 180.558 141.354 117.778 1.00 40.10  ? 624 ARG A O   1 
ATOM   3180 C CB  . ARG A 1 624 ? 182.763 138.632 116.973 1.00 34.59  ? 624 ARG A CB  1 
ATOM   3181 C CG  . ARG A 1 624 ? 184.145 138.539 116.353 1.00 37.81  ? 624 ARG A CG  1 
ATOM   3182 C CD  . ARG A 1 624 ? 184.063 138.625 114.839 1.00 42.35  ? 624 ARG A CD  1 
ATOM   3183 N NE  . ARG A 1 624 ? 183.268 139.766 114.405 1.00 44.62  ? 624 ARG A NE  1 
ATOM   3184 C CZ  . ARG A 1 624 ? 183.759 140.975 114.169 1.00 45.60  ? 624 ARG A CZ  1 
ATOM   3185 N NH1 . ARG A 1 624 ? 185.048 141.237 114.308 1.00 40.52  ? 624 ARG A NH1 1 
ATOM   3186 N NH2 . ARG A 1 624 ? 182.935 141.945 113.783 1.00 42.84  ? 624 ARG A NH2 1 
ATOM   3187 N N   . ALA B 1 229 ? 144.530 153.122 127.134 1.00 52.71  ? 229 ALA B N   1 
ATOM   3188 C CA  . ALA B 1 229 ? 145.365 152.602 126.056 1.00 56.24  ? 229 ALA B CA  1 
ATOM   3189 C C   . ALA B 1 229 ? 146.839 153.035 126.159 1.00 57.74  ? 229 ALA B C   1 
ATOM   3190 O O   . ALA B 1 229 ? 147.723 152.207 125.944 1.00 56.30  ? 229 ALA B O   1 
ATOM   3191 C CB  . ALA B 1 229 ? 144.783 152.997 124.695 1.00 53.97  ? 229 ALA B CB  1 
ATOM   3192 N N   . PRO B 1 230 ? 147.120 154.307 126.471 1.00 55.39  ? 230 PRO B N   1 
ATOM   3193 C CA  . PRO B 1 230 ? 148.516 154.689 126.717 1.00 50.09  ? 230 PRO B CA  1 
ATOM   3194 C C   . PRO B 1 230 ? 149.107 153.895 127.871 1.00 45.98  ? 230 PRO B C   1 
ATOM   3195 O O   . PRO B 1 230 ? 148.421 153.570 128.841 1.00 46.48  ? 230 PRO B O   1 
ATOM   3196 C CB  . PRO B 1 230 ? 148.423 156.182 127.046 1.00 50.19  ? 230 PRO B CB  1 
ATOM   3197 C CG  . PRO B 1 230 ? 147.218 156.633 126.331 1.00 54.10  ? 230 PRO B CG  1 
ATOM   3198 C CD  . PRO B 1 230 ? 146.248 155.498 126.444 1.00 52.70  ? 230 PRO B CD  1 
ATOM   3199 N N   . ALA B 1 231 ? 150.399 153.581 127.751 1.00 42.71  ? 231 ALA B N   1 
ATOM   3200 C CA  . ALA B 1 231 ? 151.046 152.710 128.726 1.00 41.39  ? 231 ALA B CA  1 
ATOM   3201 C C   . ALA B 1 231 ? 151.053 153.330 130.116 1.00 34.21  ? 231 ALA B C   1 
ATOM   3202 O O   . ALA B 1 231 ? 150.870 152.627 131.116 1.00 29.90  ? 231 ALA B O   1 
ATOM   3203 C CB  . ALA B 1 231 ? 152.470 152.388 128.274 1.00 39.76  ? 231 ALA B CB  1 
ATOM   3204 N N   . TRP B 1 232 ? 151.276 154.643 130.203 1.00 32.07  ? 232 TRP B N   1 
ATOM   3205 C CA  . TRP B 1 232 ? 151.281 155.294 131.508 1.00 28.79  ? 232 TRP B CA  1 
ATOM   3206 C C   . TRP B 1 232 ? 149.901 155.291 132.144 1.00 31.74  ? 232 TRP B C   1 
ATOM   3207 O O   . TRP B 1 232 ? 149.792 155.247 133.372 1.00 30.23  ? 232 TRP B O   1 
ATOM   3208 C CB  . TRP B 1 232 ? 151.811 156.722 131.392 1.00 31.18  ? 232 TRP B CB  1 
ATOM   3209 C CG  . TRP B 1 232 ? 153.299 156.787 131.328 1.00 29.62  ? 232 TRP B CG  1 
ATOM   3210 C CD1 . TRP B 1 232 ? 154.058 157.079 130.238 1.00 30.78  ? 232 TRP B CD1 1 
ATOM   3211 C CD2 . TRP B 1 232 ? 154.214 156.537 132.400 1.00 27.12  ? 232 TRP B CD2 1 
ATOM   3212 N NE1 . TRP B 1 232 ? 155.390 157.035 130.565 1.00 36.31  ? 232 TRP B NE1 1 
ATOM   3213 C CE2 . TRP B 1 232 ? 155.512 156.703 131.887 1.00 29.08  ? 232 TRP B CE2 1 
ATOM   3214 C CE3 . TRP B 1 232 ? 154.061 156.192 133.745 1.00 24.00  ? 232 TRP B CE3 1 
ATOM   3215 C CZ2 . TRP B 1 232 ? 156.649 156.536 132.669 1.00 25.19  ? 232 TRP B CZ2 1 
ATOM   3216 C CZ3 . TRP B 1 232 ? 155.190 156.027 134.518 1.00 21.82  ? 232 TRP B CZ3 1 
ATOM   3217 C CH2 . TRP B 1 232 ? 156.467 156.200 133.979 1.00 23.14  ? 232 TRP B CH2 1 
ATOM   3218 N N   . THR B 1 233 ? 148.840 155.335 131.337 1.00 36.00  ? 233 THR B N   1 
ATOM   3219 C CA  . THR B 1 233 ? 147.496 155.233 131.894 1.00 33.82  ? 233 THR B CA  1 
ATOM   3220 C C   . THR B 1 233 ? 147.282 153.882 132.563 1.00 36.28  ? 233 THR B C   1 
ATOM   3221 O O   . THR B 1 233 ? 146.758 153.812 133.679 1.00 34.89  ? 233 THR B O   1 
ATOM   3222 C CB  . THR B 1 233 ? 146.452 155.461 130.804 1.00 35.78  ? 233 THR B CB  1 
ATOM   3223 O OG1 . THR B 1 233 ? 146.616 156.774 130.257 1.00 55.35  ? 233 THR B OG1 1 
ATOM   3224 C CG2 . THR B 1 233 ? 145.054 155.336 131.377 1.00 36.74  ? 233 THR B CG2 1 
ATOM   3225 N N   . THR B 1 234 ? 147.695 152.800 131.899 1.00 32.09  ? 234 THR B N   1 
ATOM   3226 C CA  . THR B 1 234 ? 147.588 151.473 132.496 1.00 19.79  ? 234 THR B CA  1 
ATOM   3227 C C   . THR B 1 234 ? 148.473 151.351 133.728 1.00 24.96  ? 234 THR B C   1 
ATOM   3228 O O   . THR B 1 234 ? 148.084 150.729 134.726 1.00 29.13  ? 234 THR B O   1 
ATOM   3229 C CB  . THR B 1 234 ? 147.955 150.408 131.467 1.00 19.70  ? 234 THR B CB  1 
ATOM   3230 O OG1 . THR B 1 234 ? 147.196 150.616 130.273 1.00 28.46  ? 234 THR B OG1 1 
ATOM   3231 C CG2 . THR B 1 234 ? 147.657 149.031 132.010 1.00 22.81  ? 234 THR B CG2 1 
ATOM   3232 N N   . PHE B 1 235 ? 149.670 151.940 133.680 1.00 23.73  ? 235 PHE B N   1 
ATOM   3233 C CA  . PHE B 1 235 ? 150.534 151.925 134.853 1.00 20.10  ? 235 PHE B CA  1 
ATOM   3234 C C   . PHE B 1 235 ? 149.877 152.629 136.030 1.00 21.95  ? 235 PHE B C   1 
ATOM   3235 O O   . PHE B 1 235 ? 149.920 152.129 137.155 1.00 20.68  ? 235 PHE B O   1 
ATOM   3236 C CB  . PHE B 1 235 ? 151.882 152.573 134.539 1.00 21.50  ? 235 PHE B CB  1 
ATOM   3237 C CG  . PHE B 1 235 ? 152.728 152.804 135.757 1.00 21.64  ? 235 PHE B CG  1 
ATOM   3238 C CD1 . PHE B 1 235 ? 153.428 151.762 136.332 1.00 20.53  ? 235 PHE B CD1 1 
ATOM   3239 C CD2 . PHE B 1 235 ? 152.809 154.054 136.338 1.00 18.69  ? 235 PHE B CD2 1 
ATOM   3240 C CE1 . PHE B 1 235 ? 154.191 151.962 137.455 1.00 16.02  ? 235 PHE B CE1 1 
ATOM   3241 C CE2 . PHE B 1 235 ? 153.573 154.257 137.461 1.00 17.32  ? 235 PHE B CE2 1 
ATOM   3242 C CZ  . PHE B 1 235 ? 154.265 153.210 138.019 1.00 15.75  ? 235 PHE B CZ  1 
ATOM   3243 N N   . ARG B 1 236 ? 149.273 153.796 135.793 1.00 26.68  ? 236 ARG B N   1 
ATOM   3244 C CA  . ARG B 1 236 ? 148.623 154.527 136.876 1.00 26.30  ? 236 ARG B CA  1 
ATOM   3245 C C   . ARG B 1 236 ? 147.399 153.784 137.389 1.00 28.02  ? 236 ARG B C   1 
ATOM   3246 O O   . ARG B 1 236 ? 147.125 153.793 138.595 1.00 33.25  ? 236 ARG B O   1 
ATOM   3247 C CB  . ARG B 1 236 ? 148.240 155.931 136.418 1.00 26.94  ? 236 ARG B CB  1 
ATOM   3248 C CG  . ARG B 1 236 ? 149.348 156.956 136.543 1.00 28.63  ? 236 ARG B CG  1 
ATOM   3249 C CD  . ARG B 1 236 ? 148.806 158.355 136.354 1.00 22.56  ? 236 ARG B CD  1 
ATOM   3250 N NE  . ARG B 1 236 ? 148.076 158.484 135.101 1.00 26.64  ? 236 ARG B NE  1 
ATOM   3251 C CZ  . ARG B 1 236 ? 148.586 158.985 133.986 1.00 30.95  ? 236 ARG B CZ  1 
ATOM   3252 N NH1 . ARG B 1 236 ? 149.830 159.429 133.934 1.00 31.54  ? 236 ARG B NH1 1 
ATOM   3253 N NH2 . ARG B 1 236 ? 147.826 159.047 132.897 1.00 31.78  ? 236 ARG B NH2 1 
ATOM   3254 N N   . VAL B 1 237 ? 146.649 153.141 136.494 1.00 25.47  ? 237 VAL B N   1 
ATOM   3255 C CA  . VAL B 1 237 ? 145.525 152.318 136.929 1.00 25.08  ? 237 VAL B CA  1 
ATOM   3256 C C   . VAL B 1 237 ? 146.011 151.232 137.878 1.00 31.55  ? 237 VAL B C   1 
ATOM   3257 O O   . VAL B 1 237 ? 145.481 151.067 138.982 1.00 34.33  ? 237 VAL B O   1 
ATOM   3258 C CB  . VAL B 1 237 ? 144.791 151.719 135.717 1.00 19.85  ? 237 VAL B CB  1 
ATOM   3259 C CG1 . VAL B 1 237 ? 143.804 150.667 136.167 1.00 20.22  ? 237 VAL B CG1 1 
ATOM   3260 C CG2 . VAL B 1 237 ? 144.082 152.804 134.947 1.00 27.72  ? 237 VAL B CG2 1 
ATOM   3261 N N   . GLY B 1 238 ? 147.052 150.499 137.474 1.00 21.34  ? 238 GLY B N   1 
ATOM   3262 C CA  . GLY B 1 238 ? 147.590 149.458 138.336 1.00 18.76  ? 238 GLY B CA  1 
ATOM   3263 C C   . GLY B 1 238 ? 148.143 149.999 139.640 1.00 29.57  ? 238 GLY B C   1 
ATOM   3264 O O   . GLY B 1 238 ? 147.976 149.387 140.697 1.00 27.23  ? 238 GLY B O   1 
ATOM   3265 N N   . LEU B 1 239 ? 148.814 151.150 139.579 1.00 29.00  ? 239 LEU B N   1 
ATOM   3266 C CA  . LEU B 1 239 ? 149.391 151.765 140.768 1.00 20.85  ? 239 LEU B CA  1 
ATOM   3267 C C   . LEU B 1 239 ? 148.310 152.110 141.780 1.00 24.05  ? 239 LEU B C   1 
ATOM   3268 O O   . LEU B 1 239 ? 148.425 151.788 142.969 1.00 28.92  ? 239 LEU B O   1 
ATOM   3269 C CB  . LEU B 1 239 ? 150.171 153.017 140.361 1.00 21.47  ? 239 LEU B CB  1 
ATOM   3270 C CG  . LEU B 1 239 ? 150.844 153.888 141.421 1.00 27.03  ? 239 LEU B CG  1 
ATOM   3271 C CD1 . LEU B 1 239 ? 152.126 153.253 141.914 1.00 25.59  ? 239 LEU B CD1 1 
ATOM   3272 C CD2 . LEU B 1 239 ? 151.116 155.269 140.860 1.00 24.98  ? 239 LEU B CD2 1 
ATOM   3273 N N   . PHE B 1 240 ? 147.244 152.763 141.316 1.00 26.49  ? 240 PHE B N   1 
ATOM   3274 C CA  . PHE B 1 240 ? 146.140 153.108 142.201 1.00 23.98  ? 240 PHE B CA  1 
ATOM   3275 C C   . PHE B 1 240 ? 145.441 151.859 142.719 1.00 30.10  ? 240 PHE B C   1 
ATOM   3276 O O   . PHE B 1 240 ? 145.023 151.821 143.879 1.00 29.03  ? 240 PHE B O   1 
ATOM   3277 C CB  . PHE B 1 240 ? 145.155 154.023 141.478 1.00 24.60  ? 240 PHE B CB  1 
ATOM   3278 C CG  . PHE B 1 240 ? 145.740 155.345 141.072 1.00 27.99  ? 240 PHE B CG  1 
ATOM   3279 C CD1 . PHE B 1 240 ? 146.799 155.893 141.767 1.00 26.99  ? 240 PHE B CD1 1 
ATOM   3280 C CD2 . PHE B 1 240 ? 145.234 156.036 139.989 1.00 30.93  ? 240 PHE B CD2 1 
ATOM   3281 C CE1 . PHE B 1 240 ? 147.338 157.103 141.393 1.00 29.27  ? 240 PHE B CE1 1 
ATOM   3282 C CE2 . PHE B 1 240 ? 145.771 157.248 139.612 1.00 32.75  ? 240 PHE B CE2 1 
ATOM   3283 C CZ  . PHE B 1 240 ? 146.823 157.780 140.314 1.00 34.62  ? 240 PHE B CZ  1 
ATOM   3284 N N   . CYS B 1 241 ? 145.312 150.824 141.883 1.00 32.62  ? 241 CYS B N   1 
ATOM   3285 C CA  . CYS B 1 241 ? 144.719 149.570 142.343 1.00 28.22  ? 241 CYS B CA  1 
ATOM   3286 C C   . CYS B 1 241 ? 145.526 148.964 143.481 1.00 31.16  ? 241 CYS B C   1 
ATOM   3287 O O   . CYS B 1 241 ? 144.966 148.548 144.500 1.00 33.07  ? 241 CYS B O   1 
ATOM   3288 C CB  . CYS B 1 241 ? 144.619 148.574 141.189 1.00 31.21  ? 241 CYS B CB  1 
ATOM   3289 S SG  . CYS B 1 241 ? 143.510 149.046 139.866 1.00 68.64  ? 241 CYS B SG  1 
ATOM   3290 N N   . GLY B 1 242 ? 146.848 148.899 143.320 1.00 25.40  ? 242 GLY B N   1 
ATOM   3291 C CA  . GLY B 1 242 ? 147.683 148.324 144.362 1.00 20.63  ? 242 GLY B CA  1 
ATOM   3292 C C   . GLY B 1 242 ? 147.661 149.133 145.642 1.00 23.76  ? 242 GLY B C   1 
ATOM   3293 O O   . GLY B 1 242 ? 147.567 148.573 146.741 1.00 29.36  ? 242 GLY B O   1 
ATOM   3294 N N   . ILE B 1 243 ? 147.736 150.460 145.521 1.00 24.86  ? 243 ILE B N   1 
ATOM   3295 C CA  . ILE B 1 243 ? 147.660 151.308 146.706 1.00 22.77  ? 243 ILE B CA  1 
ATOM   3296 C C   . ILE B 1 243 ? 146.321 151.120 147.403 1.00 29.54  ? 243 ILE B C   1 
ATOM   3297 O O   . ILE B 1 243 ? 146.258 151.005 148.630 1.00 32.76  ? 243 ILE B O   1 
ATOM   3298 C CB  . ILE B 1 243 ? 147.898 152.783 146.339 1.00 22.75  ? 243 ILE B CB  1 
ATOM   3299 C CG1 . ILE B 1 243 ? 149.291 152.976 145.746 1.00 25.02  ? 243 ILE B CG1 1 
ATOM   3300 C CG2 . ILE B 1 243 ? 147.736 153.664 147.561 1.00 24.81  ? 243 ILE B CG2 1 
ATOM   3301 C CD1 . ILE B 1 243 ? 149.575 154.395 145.331 1.00 20.86  ? 243 ILE B CD1 1 
ATOM   3302 N N   . PHE B 1 244 ? 145.233 151.072 146.631 1.00 30.54  ? 244 PHE B N   1 
ATOM   3303 C CA  . PHE B 1 244 ? 143.903 150.897 147.200 1.00 30.97  ? 244 PHE B CA  1 
ATOM   3304 C C   . PHE B 1 244 ? 143.774 149.552 147.900 1.00 33.67  ? 244 PHE B C   1 
ATOM   3305 O O   . PHE B 1 244 ? 143.169 149.461 148.972 1.00 38.03  ? 244 PHE B O   1 
ATOM   3306 C CB  . PHE B 1 244 ? 142.862 151.045 146.090 1.00 30.19  ? 244 PHE B CB  1 
ATOM   3307 C CG  . PHE B 1 244 ? 141.443 151.037 146.568 1.00 33.70  ? 244 PHE B CG  1 
ATOM   3308 C CD1 . PHE B 1 244 ? 140.958 152.057 147.362 1.00 33.76  ? 244 PHE B CD1 1 
ATOM   3309 C CD2 . PHE B 1 244 ? 140.581 150.026 146.189 1.00 33.80  ? 244 PHE B CD2 1 
ATOM   3310 C CE1 . PHE B 1 244 ? 139.647 152.054 147.787 1.00 35.74  ? 244 PHE B CE1 1 
ATOM   3311 C CE2 . PHE B 1 244 ? 139.269 150.023 146.610 1.00 31.08  ? 244 PHE B CE2 1 
ATOM   3312 C CZ  . PHE B 1 244 ? 138.804 151.037 147.412 1.00 32.80  ? 244 PHE B CZ  1 
ATOM   3313 N N   . ILE B 1 245 ? 144.347 148.499 147.317 1.00 28.10  ? 245 ILE B N   1 
ATOM   3314 C CA  . ILE B 1 245 ? 144.284 147.174 147.930 1.00 26.74  ? 245 ILE B CA  1 
ATOM   3315 C C   . ILE B 1 245 ? 145.011 147.171 149.270 1.00 34.98  ? 245 ILE B C   1 
ATOM   3316 O O   . ILE B 1 245 ? 144.471 146.726 150.294 1.00 42.39  ? 245 ILE B O   1 
ATOM   3317 C CB  . ILE B 1 245 ? 144.864 146.116 146.974 1.00 24.32  ? 245 ILE B CB  1 
ATOM   3318 C CG1 . ILE B 1 245 ? 143.912 145.866 145.806 1.00 26.53  ? 245 ILE B CG1 1 
ATOM   3319 C CG2 . ILE B 1 245 ? 145.160 144.826 147.715 1.00 30.98  ? 245 ILE B CG2 1 
ATOM   3320 C CD1 . ILE B 1 245 ? 144.451 144.898 144.785 1.00 20.57  ? 245 ILE B CD1 1 
ATOM   3321 N N   . VAL B 1 246 ? 146.248 147.672 149.285 1.00 29.88  ? 246 VAL B N   1 
ATOM   3322 C CA  . VAL B 1 246 ? 147.010 147.654 150.529 1.00 27.43  ? 246 VAL B CA  1 
ATOM   3323 C C   . VAL B 1 246 ? 146.368 148.571 151.563 1.00 30.50  ? 246 VAL B C   1 
ATOM   3324 O O   . VAL B 1 246 ? 146.371 148.271 152.763 1.00 33.48  ? 246 VAL B O   1 
ATOM   3325 C CB  . VAL B 1 246 ? 148.483 148.020 150.275 1.00 25.85  ? 246 VAL B CB  1 
ATOM   3326 C CG1 . VAL B 1 246 ? 149.299 147.772 151.527 1.00 31.31  ? 246 VAL B CG1 1 
ATOM   3327 C CG2 . VAL B 1 246 ? 149.034 147.202 149.132 1.00 25.99  ? 246 VAL B CG2 1 
ATOM   3328 N N   . LEU B 1 247 ? 145.793 149.692 151.120 1.00 31.60  ? 247 LEU B N   1 
ATOM   3329 C CA  . LEU B 1 247 ? 145.137 150.604 152.049 1.00 31.33  ? 247 LEU B CA  1 
ATOM   3330 C C   . LEU B 1 247 ? 143.873 149.988 152.633 1.00 35.71  ? 247 LEU B C   1 
ATOM   3331 O O   . LEU B 1 247 ? 143.572 150.197 153.808 1.00 38.76  ? 247 LEU B O   1 
ATOM   3332 C CB  . LEU B 1 247 ? 144.821 151.930 151.360 1.00 27.73  ? 247 LEU B CB  1 
ATOM   3333 C CG  . LEU B 1 247 ? 145.997 152.883 151.141 1.00 24.28  ? 247 LEU B CG  1 
ATOM   3334 C CD1 . LEU B 1 247 ? 145.520 154.193 150.553 1.00 26.88  ? 247 LEU B CD1 1 
ATOM   3335 C CD2 . LEU B 1 247 ? 146.749 153.118 152.433 1.00 27.07  ? 247 LEU B CD2 1 
ATOM   3336 N N   . ASN B 1 248 ? 143.121 149.227 151.836 1.00 36.92  ? 248 ASN B N   1 
ATOM   3337 C CA  . ASN B 1 248 ? 141.956 148.529 152.371 1.00 36.80  ? 248 ASN B CA  1 
ATOM   3338 C C   . ASN B 1 248 ? 142.361 147.475 153.390 1.00 43.05  ? 248 ASN B C   1 
ATOM   3339 O O   . ASN B 1 248 ? 141.697 147.312 154.423 1.00 49.74  ? 248 ASN B O   1 
ATOM   3340 C CB  . ASN B 1 248 ? 141.162 147.882 151.242 1.00 37.54  ? 248 ASN B CB  1 
ATOM   3341 C CG  . ASN B 1 248 ? 140.437 148.889 150.394 1.00 46.49  ? 248 ASN B CG  1 
ATOM   3342 O OD1 . ASN B 1 248 ? 140.042 149.951 150.870 1.00 48.04  ? 248 ASN B OD1 1 
ATOM   3343 N ND2 . ASN B 1 248 ? 140.250 148.561 149.125 1.00 53.70  ? 248 ASN B ND2 1 
ATOM   3344 N N   . ILE B 1 249 ? 143.434 146.732 153.109 1.00 40.98  ? 249 ILE B N   1 
ATOM   3345 C CA  . ILE B 1 249 ? 143.892 145.722 154.061 1.00 40.15  ? 249 ILE B CA  1 
ATOM   3346 C C   . ILE B 1 249 ? 144.337 146.382 155.362 1.00 42.42  ? 249 ILE B C   1 
ATOM   3347 O O   . ILE B 1 249 ? 143.977 145.939 156.461 1.00 43.38  ? 249 ILE B O   1 
ATOM   3348 C CB  . ILE B 1 249 ? 145.008 144.865 153.439 1.00 36.55  ? 249 ILE B CB  1 
ATOM   3349 C CG1 . ILE B 1 249 ? 144.482 144.151 152.195 1.00 31.34  ? 249 ILE B CG1 1 
ATOM   3350 C CG2 . ILE B 1 249 ? 145.523 143.852 154.443 1.00 34.95  ? 249 ILE B CG2 1 
ATOM   3351 C CD1 . ILE B 1 249 ? 145.522 143.337 151.475 1.00 37.19  ? 249 ILE B CD1 1 
ATOM   3352 N N   . THR B 1 250 ? 145.110 147.467 155.261 1.00 37.07  ? 250 THR B N   1 
ATOM   3353 C CA  . THR B 1 250 ? 145.517 148.185 156.464 1.00 36.35  ? 250 THR B CA  1 
ATOM   3354 C C   . THR B 1 250 ? 144.322 148.795 157.180 1.00 42.75  ? 250 THR B C   1 
ATOM   3355 O O   . THR B 1 250 ? 144.313 148.879 158.410 1.00 51.49  ? 250 THR B O   1 
ATOM   3356 C CB  . THR B 1 250 ? 146.536 149.272 156.125 1.00 32.21  ? 250 THR B CB  1 
ATOM   3357 O OG1 . THR B 1 250 ? 146.012 150.119 155.099 1.00 36.17  ? 250 THR B OG1 1 
ATOM   3358 C CG2 . THR B 1 250 ? 147.836 148.655 155.649 1.00 39.04  ? 250 THR B CG2 1 
ATOM   3359 N N   . LEU B 1 251 ? 143.299 149.207 156.431 1.00 45.43  ? 251 LEU B N   1 
ATOM   3360 C CA  . LEU B 1 251 ? 142.116 149.811 157.030 1.00 46.63  ? 251 LEU B CA  1 
ATOM   3361 C C   . LEU B 1 251 ? 141.324 148.794 157.839 1.00 51.20  ? 251 LEU B C   1 
ATOM   3362 O O   . LEU B 1 251 ? 140.898 149.084 158.962 1.00 53.70  ? 251 LEU B O   1 
ATOM   3363 C CB  . LEU B 1 251 ? 141.250 150.420 155.929 1.00 48.49  ? 251 LEU B CB  1 
ATOM   3364 C CG  . LEU B 1 251 ? 140.122 151.375 156.295 1.00 48.80  ? 251 LEU B CG  1 
ATOM   3365 C CD1 . LEU B 1 251 ? 140.674 152.600 156.983 1.00 43.79  ? 251 LEU B CD1 1 
ATOM   3366 C CD2 . LEU B 1 251 ? 139.373 151.761 155.038 1.00 41.74  ? 251 LEU B CD2 1 
ATOM   3367 N N   . VAL B 1 252 ? 141.120 147.596 157.290 1.00 49.29  ? 252 VAL B N   1 
ATOM   3368 C CA  . VAL B 1 252 ? 140.405 146.572 158.046 1.00 49.61  ? 252 VAL B CA  1 
ATOM   3369 C C   . VAL B 1 252 ? 141.242 146.106 159.234 1.00 59.57  ? 252 VAL B C   1 
ATOM   3370 O O   . VAL B 1 252 ? 140.707 145.850 160.321 1.00 66.48  ? 252 VAL B O   1 
ATOM   3371 C CB  . VAL B 1 252 ? 139.983 145.402 157.137 1.00 47.35  ? 252 VAL B CB  1 
ATOM   3372 C CG1 . VAL B 1 252 ? 141.178 144.725 156.512 1.00 50.69  ? 252 VAL B CG1 1 
ATOM   3373 C CG2 . VAL B 1 252 ? 139.157 144.397 157.921 1.00 55.78  ? 252 VAL B CG2 1 
ATOM   3374 N N   . LEU B 1 253 ? 142.566 146.016 159.065 1.00 58.22  ? 253 LEU B N   1 
ATOM   3375 C CA  . LEU B 1 253 ? 143.417 145.653 160.195 1.00 57.79  ? 253 LEU B CA  1 
ATOM   3376 C C   . LEU B 1 253 ? 143.345 146.697 161.303 1.00 55.69  ? 253 LEU B C   1 
ATOM   3377 O O   . LEU B 1 253 ? 143.304 146.348 162.488 1.00 61.59  ? 253 LEU B O   1 
ATOM   3378 C CB  . LEU B 1 253 ? 144.859 145.459 159.728 1.00 55.01  ? 253 LEU B CB  1 
ATOM   3379 C CG  . LEU B 1 253 ? 145.132 144.181 158.937 1.00 53.49  ? 253 LEU B CG  1 
ATOM   3380 C CD1 . LEU B 1 253 ? 146.577 144.137 158.473 1.00 48.46  ? 253 LEU B CD1 1 
ATOM   3381 C CD2 . LEU B 1 253 ? 144.796 142.958 159.772 1.00 50.73  ? 253 LEU B CD2 1 
ATOM   3382 N N   . ALA B 1 254 ? 143.335 147.980 160.941 1.00 50.33  ? 254 ALA B N   1 
ATOM   3383 C CA  . ALA B 1 254 ? 143.192 149.033 161.939 1.00 58.26  ? 254 ALA B CA  1 
ATOM   3384 C C   . ALA B 1 254 ? 141.832 148.968 162.619 1.00 66.28  ? 254 ALA B C   1 
ATOM   3385 O O   . ALA B 1 254 ? 141.740 149.097 163.843 1.00 73.63  ? 254 ALA B O   1 
ATOM   3386 C CB  . ALA B 1 254 ? 143.403 150.401 161.293 1.00 54.85  ? 254 ALA B CB  1 
ATOM   3387 N N   . ALA B 1 255 ? 140.765 148.758 161.846 1.00 65.67  ? 255 ALA B N   1 
ATOM   3388 C CA  . ALA B 1 255 ? 139.437 148.658 162.442 1.00 67.40  ? 255 ALA B CA  1 
ATOM   3389 C C   . ALA B 1 255 ? 139.366 147.498 163.426 1.00 75.04  ? 255 ALA B C   1 
ATOM   3390 O O   . ALA B 1 255 ? 138.676 147.582 164.448 1.00 84.09  ? 255 ALA B O   1 
ATOM   3391 C CB  . ALA B 1 255 ? 138.379 148.508 161.351 1.00 63.74  ? 255 ALA B CB  1 
ATOM   3392 N N   . VAL B 1 256 ? 140.071 146.404 163.134 1.00 70.17  ? 256 VAL B N   1 
ATOM   3393 C CA  . VAL B 1 256 ? 140.109 145.286 164.071 1.00 71.24  ? 256 VAL B CA  1 
ATOM   3394 C C   . VAL B 1 256 ? 140.928 145.638 165.311 1.00 75.22  ? 256 VAL B C   1 
ATOM   3395 O O   . VAL B 1 256 ? 140.507 145.370 166.442 1.00 79.31  ? 256 VAL B O   1 
ATOM   3396 C CB  . VAL B 1 256 ? 140.648 144.023 163.376 1.00 73.70  ? 256 VAL B CB  1 
ATOM   3397 C CG1 . VAL B 1 256 ? 140.865 142.912 164.389 1.00 76.99  ? 256 VAL B CG1 1 
ATOM   3398 C CG2 . VAL B 1 256 ? 139.689 143.569 162.291 1.00 73.59  ? 256 VAL B CG2 1 
ATOM   3399 N N   . PHE B 1 257 ? 142.099 146.254 165.127 1.00 79.07  ? 257 PHE B N   1 
ATOM   3400 C CA  . PHE B 1 257 ? 143.061 146.444 166.209 1.00 77.32  ? 257 PHE B CA  1 
ATOM   3401 C C   . PHE B 1 257 ? 143.204 147.905 166.635 1.00 81.75  ? 257 PHE B C   1 
ATOM   3402 O O   . PHE B 1 257 ? 144.294 148.334 167.020 1.00 82.46  ? 257 PHE B O   1 
ATOM   3403 C CB  . PHE B 1 257 ? 144.429 145.890 165.812 1.00 73.43  ? 257 PHE B CB  1 
ATOM   3404 C CG  . PHE B 1 257 ? 144.430 144.421 165.501 1.00 79.37  ? 257 PHE B CG  1 
ATOM   3405 C CD1 . PHE B 1 257 ? 144.450 143.484 166.518 1.00 86.79  ? 257 PHE B CD1 1 
ATOM   3406 C CD2 . PHE B 1 257 ? 144.430 143.979 164.191 1.00 80.80  ? 257 PHE B CD2 1 
ATOM   3407 C CE1 . PHE B 1 257 ? 144.457 142.133 166.232 1.00 96.93  ? 257 PHE B CE1 1 
ATOM   3408 C CE2 . PHE B 1 257 ? 144.437 142.630 163.899 1.00 84.16  ? 257 PHE B CE2 1 
ATOM   3409 C CZ  . PHE B 1 257 ? 144.451 141.706 164.921 1.00 92.07  ? 257 PHE B CZ  1 
ATOM   3410 N N   . LYS B 1 258 ? 142.129 148.680 166.575 1.00 82.74  ? 258 LYS B N   1 
ATOM   3411 C CA  . LYS B 1 258 ? 142.164 150.061 167.049 1.00 86.79  ? 258 LYS B CA  1 
ATOM   3412 C C   . LYS B 1 258 ? 140.765 150.427 167.536 1.00 96.83  ? 258 LYS B C   1 
ATOM   3413 O O   . LYS B 1 258 ? 139.947 149.546 167.819 1.00 94.05  ? 258 LYS B O   1 
ATOM   3414 C CB  . LYS B 1 258 ? 142.687 151.004 165.951 1.00 81.38  ? 258 LYS B CB  1 
ATOM   3415 C CG  . LYS B 1 258 ? 143.478 152.196 166.462 1.00 88.83  ? 258 LYS B CG  1 
ATOM   3416 C CD  . LYS B 1 258 ? 144.784 151.757 167.101 1.00 96.32  ? 258 LYS B CD  1 
ATOM   3417 C CE  . LYS B 1 258 ? 145.639 152.953 167.487 1.00 97.27  ? 258 LYS B CE  1 
ATOM   3418 N NZ  . LYS B 1 258 ? 146.961 152.537 168.029 1.00 87.10  ? 258 LYS B NZ  1 
ATOM   3419 N N   . LEU B 1 259 ? 140.507 151.732 167.663 1.00 101.97 ? 259 LEU B N   1 
ATOM   3420 C CA  . LEU B 1 259 ? 139.220 152.283 168.080 1.00 107.25 ? 259 LEU B CA  1 
ATOM   3421 C C   . LEU B 1 259 ? 138.924 151.981 169.544 1.00 117.21 ? 259 LEU B C   1 
ATOM   3422 O O   . LEU B 1 259 ? 139.742 151.373 170.241 1.00 120.78 ? 259 LEU B O   1 
ATOM   3423 C CB  . LEU B 1 259 ? 138.085 151.760 167.193 1.00 105.42 ? 259 LEU B CB  1 
ATOM   3424 C CG  . LEU B 1 259 ? 138.203 152.044 165.695 1.00 96.73  ? 259 LEU B CG  1 
ATOM   3425 C CD1 . LEU B 1 259 ? 137.016 151.463 164.948 1.00 90.28  ? 259 LEU B CD1 1 
ATOM   3426 C CD2 . LEU B 1 259 ? 138.319 153.537 165.444 1.00 91.39  ? 259 LEU B CD2 1 
ATOM   3427 N N   . GLU B 1 260 ? 137.758 152.412 170.016 1.00 125.68 ? 260 GLU B N   1 
ATOM   3428 C CA  . GLU B 1 260 ? 137.340 152.227 171.397 1.00 135.45 ? 260 GLU B CA  1 
ATOM   3429 C C   . GLU B 1 260 ? 136.039 151.439 171.434 1.00 141.25 ? 260 GLU B C   1 
ATOM   3430 O O   . GLU B 1 260 ? 135.127 151.691 170.640 1.00 140.61 ? 260 GLU B O   1 
ATOM   3431 C CB  . GLU B 1 260 ? 137.158 153.576 172.104 1.00 141.19 ? 260 GLU B CB  1 
ATOM   3432 C CG  . GLU B 1 260 ? 136.738 153.465 173.563 1.00 146.71 ? 260 GLU B CG  1 
ATOM   3433 C CD  . GLU B 1 260 ? 136.449 154.815 174.192 1.00 149.19 ? 260 GLU B CD  1 
ATOM   3434 O OE1 . GLU B 1 260 ? 136.646 155.844 173.512 1.00 147.66 ? 260 GLU B OE1 1 
ATOM   3435 O OE2 . GLU B 1 260 ? 136.024 154.847 175.366 1.00 150.72 ? 260 GLU B OE2 1 
ATOM   3436 N N   . THR B 1 261 ? 135.961 150.481 172.361 1.00 144.06 ? 261 THR B N   1 
ATOM   3437 C CA  . THR B 1 261 ? 134.766 149.650 172.469 1.00 146.70 ? 261 THR B CA  1 
ATOM   3438 C C   . THR B 1 261 ? 133.543 150.483 172.833 1.00 146.39 ? 261 THR B C   1 
ATOM   3439 O O   . THR B 1 261 ? 132.453 150.270 172.289 1.00 145.51 ? 261 THR B O   1 
ATOM   3440 C CB  . THR B 1 261 ? 134.987 148.545 173.503 1.00 145.71 ? 261 THR B CB  1 
ATOM   3441 O OG1 . THR B 1 261 ? 136.186 147.826 173.190 1.00 140.37 ? 261 THR B OG1 1 
ATOM   3442 C CG2 . THR B 1 261 ? 133.812 147.578 173.509 1.00 144.69 ? 261 THR B CG2 1 
ATOM   3443 N N   . ASP B 1 262 ? 133.703 151.435 173.756 1.00 148.32 ? 262 ASP B N   1 
ATOM   3444 C CA  . ASP B 1 262 ? 132.575 152.262 174.172 1.00 150.67 ? 262 ASP B CA  1 
ATOM   3445 C C   . ASP B 1 262 ? 132.069 153.138 173.032 1.00 148.14 ? 262 ASP B C   1 
ATOM   3446 O O   . ASP B 1 262 ? 130.855 153.307 172.864 1.00 144.78 ? 262 ASP B O   1 
ATOM   3447 C CB  . ASP B 1 262 ? 132.969 153.121 175.373 1.00 150.65 ? 262 ASP B CB  1 
ATOM   3448 C CG  . ASP B 1 262 ? 133.274 152.294 176.607 1.00 152.67 ? 262 ASP B CG  1 
ATOM   3449 O OD1 . ASP B 1 262 ? 133.273 151.049 176.504 1.00 153.90 ? 262 ASP B OD1 1 
ATOM   3450 O OD2 . ASP B 1 262 ? 133.510 152.889 177.680 1.00 153.98 ? 262 ASP B OD2 1 
ATOM   3451 N N   . ARG B 1 263 ? 132.977 153.703 172.241 1.00 146.72 ? 263 ARG B N   1 
ATOM   3452 C CA  . ARG B 1 263 ? 132.595 154.637 171.191 1.00 141.82 ? 263 ARG B CA  1 
ATOM   3453 C C   . ARG B 1 263 ? 132.101 153.891 169.958 1.00 137.85 ? 263 ARG B C   1 
ATOM   3454 O O   . ARG B 1 263 ? 132.749 152.951 169.487 1.00 132.87 ? 263 ARG B O   1 
ATOM   3455 C CB  . ARG B 1 263 ? 133.773 155.538 170.827 1.00 138.41 ? 263 ARG B CB  1 
ATOM   3456 C CG  . ARG B 1 263 ? 133.487 156.495 169.682 1.00 139.39 ? 263 ARG B CG  1 
ATOM   3457 C CD  . ARG B 1 263 ? 134.628 157.475 169.463 1.00 142.19 ? 263 ARG B CD  1 
ATOM   3458 N NE  . ARG B 1 263 ? 134.735 158.448 170.544 1.00 142.07 ? 263 ARG B NE  1 
ATOM   3459 C CZ  . ARG B 1 263 ? 135.589 158.358 171.554 1.00 140.83 ? 263 ARG B CZ  1 
ATOM   3460 N NH1 . ARG B 1 263 ? 136.436 157.347 171.655 1.00 138.55 ? 263 ARG B NH1 1 
ATOM   3461 N NH2 . ARG B 1 263 ? 135.594 159.307 172.486 1.00 139.28 ? 263 ARG B NH2 1 
ATOM   3462 N N   . SER B 1 264 ? 130.952 154.315 169.437 1.00 137.24 ? 264 SER B N   1 
ATOM   3463 C CA  . SER B 1 264 ? 130.403 153.745 168.219 1.00 125.50 ? 264 SER B CA  1 
ATOM   3464 C C   . SER B 1 264 ? 131.106 154.327 166.996 1.00 116.64 ? 264 SER B C   1 
ATOM   3465 O O   . SER B 1 264 ? 131.866 155.295 167.082 1.00 119.41 ? 264 SER B O   1 
ATOM   3466 C CB  . SER B 1 264 ? 128.898 153.997 168.141 1.00 121.53 ? 264 SER B CB  1 
ATOM   3467 O OG  . SER B 1 264 ? 128.615 155.385 168.147 1.00 118.84 ? 264 SER B OG  1 
ATOM   3468 N N   . ILE B 1 265 ? 130.852 153.717 165.840 1.00 109.80 ? 265 ILE B N   1 
ATOM   3469 C CA  . ILE B 1 265 ? 131.484 154.147 164.598 1.00 100.41 ? 265 ILE B CA  1 
ATOM   3470 C C   . ILE B 1 265 ? 130.436 154.346 163.513 1.00 91.77  ? 265 ILE B C   1 
ATOM   3471 O O   . ILE B 1 265 ? 130.762 154.380 162.322 1.00 92.51  ? 265 ILE B O   1 
ATOM   3472 C CB  . ILE B 1 265 ? 132.559 153.142 164.148 1.00 98.09  ? 265 ILE B CB  1 
ATOM   3473 C CG1 . ILE B 1 265 ? 132.177 151.715 164.554 1.00 99.27  ? 265 ILE B CG1 1 
ATOM   3474 C CG2 . ILE B 1 265 ? 133.909 153.517 164.731 1.00 101.07 ? 265 ILE B CG2 1 
ATOM   3475 C CD1 . ILE B 1 265 ? 131.089 151.086 163.710 1.00 92.12  ? 265 ILE B CD1 1 
ATOM   3476 N N   . TRP B 1 266 ? 129.177 154.486 163.910 1.00 91.89  ? 266 TRP B N   1 
ATOM   3477 C CA  . TRP B 1 266 ? 128.097 154.574 162.935 1.00 89.34  ? 266 TRP B CA  1 
ATOM   3478 C C   . TRP B 1 266 ? 128.035 155.926 162.227 1.00 88.45  ? 266 TRP B C   1 
ATOM   3479 O O   . TRP B 1 266 ? 127.750 155.957 161.024 1.00 88.06  ? 266 TRP B O   1 
ATOM   3480 C CB  . TRP B 1 266 ? 126.755 154.251 163.595 1.00 91.89  ? 266 TRP B CB  1 
ATOM   3481 C CG  . TRP B 1 266 ? 126.542 152.782 163.727 1.00 96.57  ? 266 TRP B CG  1 
ATOM   3482 C CD1 . TRP B 1 266 ? 126.467 152.063 164.881 1.00 99.10  ? 266 TRP B CD1 1 
ATOM   3483 C CD2 . TRP B 1 266 ? 126.405 151.841 162.657 1.00 97.57  ? 266 TRP B CD2 1 
ATOM   3484 N NE1 . TRP B 1 266 ? 126.278 150.732 164.597 1.00 100.56 ? 266 TRP B NE1 1 
ATOM   3485 C CE2 . TRP B 1 266 ? 126.238 150.571 163.238 1.00 98.67  ? 266 TRP B CE2 1 
ATOM   3486 C CE3 . TRP B 1 266 ? 126.401 151.952 161.264 1.00 94.35  ? 266 TRP B CE3 1 
ATOM   3487 C CZ2 . TRP B 1 266 ? 126.069 149.420 162.475 1.00 93.18  ? 266 TRP B CZ2 1 
ATOM   3488 C CZ3 . TRP B 1 266 ? 126.235 150.810 160.509 1.00 88.08  ? 266 TRP B CZ3 1 
ATOM   3489 C CH2 . TRP B 1 266 ? 126.072 149.561 161.115 1.00 89.67  ? 266 TRP B CH2 1 
ATOM   3490 N N   . PRO B 1 267 ? 128.255 157.060 162.908 1.00 86.71  ? 267 PRO B N   1 
ATOM   3491 C CA  . PRO B 1 267 ? 128.372 158.318 162.151 1.00 81.41  ? 267 PRO B CA  1 
ATOM   3492 C C   . PRO B 1 267 ? 129.487 158.290 161.121 1.00 79.42  ? 267 PRO B C   1 
ATOM   3493 O O   . PRO B 1 267 ? 129.314 158.805 160.011 1.00 76.46  ? 267 PRO B O   1 
ATOM   3494 C CB  . PRO B 1 267 ? 128.629 159.358 163.248 1.00 88.43  ? 267 PRO B CB  1 
ATOM   3495 C CG  . PRO B 1 267 ? 127.964 158.797 164.440 1.00 94.24  ? 267 PRO B CG  1 
ATOM   3496 C CD  . PRO B 1 267 ? 128.180 157.314 164.359 1.00 94.51  ? 267 PRO B CD  1 
ATOM   3497 N N   . LEU B 1 268 ? 130.623 157.674 161.451 1.00 79.03  ? 268 LEU B N   1 
ATOM   3498 C CA  . LEU B 1 268 ? 131.718 157.571 160.493 1.00 72.27  ? 268 LEU B CA  1 
ATOM   3499 C C   . LEU B 1 268 ? 131.317 156.735 159.283 1.00 67.96  ? 268 LEU B C   1 
ATOM   3500 O O   . LEU B 1 268 ? 131.618 157.096 158.136 1.00 61.47  ? 268 LEU B O   1 
ATOM   3501 C CB  . LEU B 1 268 ? 132.944 156.971 161.179 1.00 67.40  ? 268 LEU B CB  1 
ATOM   3502 C CG  . LEU B 1 268 ? 134.300 157.181 160.516 1.00 58.50  ? 268 LEU B CG  1 
ATOM   3503 C CD1 . LEU B 1 268 ? 134.650 158.654 160.502 1.00 52.05  ? 268 LEU B CD1 1 
ATOM   3504 C CD2 . LEU B 1 268 ? 135.352 156.391 161.257 1.00 62.18  ? 268 LEU B CD2 1 
ATOM   3505 N N   . ILE B 1 269 ? 130.639 155.610 159.523 1.00 69.88  ? 269 ILE B N   1 
ATOM   3506 C CA  . ILE B 1 269 ? 130.189 154.758 158.426 1.00 64.74  ? 269 ILE B CA  1 
ATOM   3507 C C   . ILE B 1 269 ? 129.189 155.503 157.555 1.00 65.87  ? 269 ILE B C   1 
ATOM   3508 O O   . ILE B 1 269 ? 129.273 155.478 156.324 1.00 68.22  ? 269 ILE B O   1 
ATOM   3509 C CB  . ILE B 1 269 ? 129.593 153.448 158.972 1.00 63.41  ? 269 ILE B CB  1 
ATOM   3510 C CG1 . ILE B 1 269 ? 130.678 152.609 159.647 1.00 71.69  ? 269 ILE B CG1 1 
ATOM   3511 C CG2 . ILE B 1 269 ? 128.932 152.659 157.857 1.00 66.65  ? 269 ILE B CG2 1 
ATOM   3512 C CD1 . ILE B 1 269 ? 130.188 151.271 160.148 1.00 77.82  ? 269 ILE B CD1 1 
ATOM   3513 N N   . ARG B 1 270 ? 128.227 156.182 158.182 1.00 64.27  ? 270 ARG B N   1 
ATOM   3514 C CA  . ARG B 1 270 ? 127.224 156.921 157.428 1.00 62.18  ? 270 ARG B CA  1 
ATOM   3515 C C   . ARG B 1 270 ? 127.798 158.136 156.715 1.00 62.40  ? 270 ARG B C   1 
ATOM   3516 O O   . ARG B 1 270 ? 127.174 158.626 155.770 1.00 69.51  ? 270 ARG B O   1 
ATOM   3517 C CB  . ARG B 1 270 ? 126.079 157.342 158.350 1.00 72.52  ? 270 ARG B CB  1 
ATOM   3518 C CG  . ARG B 1 270 ? 125.028 156.260 158.547 1.00 76.79  ? 270 ARG B CG  1 
ATOM   3519 C CD  . ARG B 1 270 ? 123.978 156.657 159.570 1.00 84.72  ? 270 ARG B CD  1 
ATOM   3520 N NE  . ARG B 1 270 ? 124.502 156.633 160.930 1.00 89.84  ? 270 ARG B NE  1 
ATOM   3521 C CZ  . ARG B 1 270 ? 123.775 156.847 162.019 1.00 93.36  ? 270 ARG B CZ  1 
ATOM   3522 N NH1 . ARG B 1 270 ? 122.479 157.103 161.945 1.00 98.26  ? 270 ARG B NH1 1 
ATOM   3523 N NH2 . ARG B 1 270 ? 124.362 156.801 163.211 1.00 95.56  ? 270 ARG B NH2 1 
ATOM   3524 N N   . ILE B 1 271 ? 128.958 158.629 157.137 1.00 60.03  ? 271 ILE B N   1 
ATOM   3525 C CA  . ILE B 1 271 ? 129.613 159.718 156.421 1.00 58.36  ? 271 ILE B CA  1 
ATOM   3526 C C   . ILE B 1 271 ? 130.402 159.206 155.221 1.00 53.32  ? 271 ILE B C   1 
ATOM   3527 O O   . ILE B 1 271 ? 130.298 159.758 154.124 1.00 49.96  ? 271 ILE B O   1 
ATOM   3528 C CB  . ILE B 1 271 ? 130.510 160.516 157.387 1.00 63.00  ? 271 ILE B CB  1 
ATOM   3529 C CG1 . ILE B 1 271 ? 129.659 161.403 158.295 1.00 68.97  ? 271 ILE B CG1 1 
ATOM   3530 C CG2 . ILE B 1 271 ? 131.508 161.355 156.617 1.00 58.42  ? 271 ILE B CG2 1 
ATOM   3531 C CD1 . ILE B 1 271 ? 130.456 162.127 159.351 1.00 74.74  ? 271 ILE B CD1 1 
ATOM   3532 N N   . TYR B 1 272 ? 131.191 158.145 155.397 1.00 52.91  ? 272 TYR B N   1 
ATOM   3533 C CA  . TYR B 1 272 ? 132.038 157.648 154.317 1.00 43.21  ? 272 TYR B CA  1 
ATOM   3534 C C   . TYR B 1 272 ? 131.322 156.695 153.366 1.00 43.79  ? 272 TYR B C   1 
ATOM   3535 O O   . TYR B 1 272 ? 131.892 156.335 152.326 1.00 43.04  ? 272 TYR B O   1 
ATOM   3536 C CB  . TYR B 1 272 ? 133.275 156.960 154.896 1.00 37.74  ? 272 TYR B CB  1 
ATOM   3537 C CG  . TYR B 1 272 ? 134.336 157.929 155.356 1.00 41.93  ? 272 TYR B CG  1 
ATOM   3538 C CD1 . TYR B 1 272 ? 135.177 158.545 154.444 1.00 38.19  ? 272 TYR B CD1 1 
ATOM   3539 C CD2 . TYR B 1 272 ? 134.495 158.230 156.698 1.00 46.67  ? 272 TYR B CD2 1 
ATOM   3540 C CE1 . TYR B 1 272 ? 136.142 159.430 154.854 1.00 36.65  ? 272 TYR B CE1 1 
ATOM   3541 C CE2 . TYR B 1 272 ? 135.462 159.115 157.117 1.00 43.71  ? 272 TYR B CE2 1 
ATOM   3542 C CZ  . TYR B 1 272 ? 136.282 159.711 156.192 1.00 44.50  ? 272 TYR B CZ  1 
ATOM   3543 O OH  . TYR B 1 272 ? 137.248 160.593 156.606 1.00 49.49  ? 272 TYR B OH  1 
ATOM   3544 N N   . ARG B 1 273 ? 130.091 156.294 153.685 1.00 47.85  ? 273 ARG B N   1 
ATOM   3545 C CA  . ARG B 1 273 ? 129.358 155.377 152.824 1.00 38.63  ? 273 ARG B CA  1 
ATOM   3546 C C   . ARG B 1 273 ? 129.057 156.002 151.470 1.00 41.64  ? 273 ARG B C   1 
ATOM   3547 O O   . ARG B 1 273 ? 129.126 155.324 150.441 1.00 41.71  ? 273 ARG B O   1 
ATOM   3548 C CB  . ARG B 1 273 ? 128.074 154.941 153.524 1.00 41.90  ? 273 ARG B CB  1 
ATOM   3549 C CG  . ARG B 1 273 ? 127.186 154.020 152.720 1.00 49.43  ? 273 ARG B CG  1 
ATOM   3550 C CD  . ARG B 1 273 ? 126.004 153.567 153.556 1.00 57.56  ? 273 ARG B CD  1 
ATOM   3551 N NE  . ARG B 1 273 ? 125.296 154.696 154.146 1.00 51.18  ? 273 ARG B NE  1 
ATOM   3552 C CZ  . ARG B 1 273 ? 124.274 154.584 154.981 1.00 57.07  ? 273 ARG B CZ  1 
ATOM   3553 N NH1 . ARG B 1 273 ? 123.810 153.402 155.350 1.00 63.02  ? 273 ARG B NH1 1 
ATOM   3554 N NH2 . ARG B 1 273 ? 123.702 155.685 155.458 1.00 62.26  ? 273 ARG B NH2 1 
ATOM   3555 N N   . GLY B 1 274 ? 128.720 157.293 151.446 1.00 41.53  ? 274 GLY B N   1 
ATOM   3556 C CA  . GLY B 1 274 ? 128.447 157.948 150.176 1.00 39.38  ? 274 GLY B CA  1 
ATOM   3557 C C   . GLY B 1 274 ? 129.656 157.972 149.261 1.00 40.62  ? 274 GLY B C   1 
ATOM   3558 O O   . GLY B 1 274 ? 129.557 157.676 148.066 1.00 44.33  ? 274 GLY B O   1 
ATOM   3559 N N   . GLY B 1 275 ? 130.819 158.321 149.812 1.00 43.17  ? 275 GLY B N   1 
ATOM   3560 C CA  . GLY B 1 275 ? 132.036 158.303 149.019 1.00 39.11  ? 275 GLY B CA  1 
ATOM   3561 C C   . GLY B 1 275 ? 132.395 156.912 148.535 1.00 35.62  ? 275 GLY B C   1 
ATOM   3562 O O   . GLY B 1 275 ? 132.819 156.733 147.389 1.00 40.26  ? 275 GLY B O   1 
ATOM   3563 N N   . PHE B 1 276 ? 132.227 155.905 149.397 1.00 35.21  ? 276 PHE B N   1 
ATOM   3564 C CA  . PHE B 1 276 ? 132.488 154.535 148.969 1.00 30.99  ? 276 PHE B CA  1 
ATOM   3565 C C   . PHE B 1 276 ? 131.551 154.121 147.842 1.00 33.81  ? 276 PHE B C   1 
ATOM   3566 O O   . PHE B 1 276 ? 131.970 153.451 146.893 1.00 34.35  ? 276 PHE B O   1 
ATOM   3567 C CB  . PHE B 1 276 ? 132.357 153.571 150.144 1.00 31.58  ? 276 PHE B CB  1 
ATOM   3568 C CG  . PHE B 1 276 ? 132.558 152.134 149.764 1.00 35.18  ? 276 PHE B CG  1 
ATOM   3569 C CD1 . PHE B 1 276 ? 133.833 151.616 149.628 1.00 31.03  ? 276 PHE B CD1 1 
ATOM   3570 C CD2 . PHE B 1 276 ? 131.474 151.305 149.531 1.00 34.70  ? 276 PHE B CD2 1 
ATOM   3571 C CE1 . PHE B 1 276 ? 134.023 150.299 149.274 1.00 31.64  ? 276 PHE B CE1 1 
ATOM   3572 C CE2 . PHE B 1 276 ? 131.659 149.987 149.173 1.00 32.27  ? 276 PHE B CE2 1 
ATOM   3573 C CZ  . PHE B 1 276 ? 132.934 149.484 149.044 1.00 36.92  ? 276 PHE B CZ  1 
ATOM   3574 N N   . LEU B 1 277 ? 130.276 154.501 147.936 1.00 34.66  ? 277 LEU B N   1 
ATOM   3575 C CA  . LEU B 1 277 ? 129.326 154.172 146.880 1.00 30.36  ? 277 LEU B CA  1 
ATOM   3576 C C   . LEU B 1 277 ? 129.688 154.865 145.577 1.00 30.03  ? 277 LEU B C   1 
ATOM   3577 O O   . LEU B 1 277 ? 129.533 154.285 144.500 1.00 32.03  ? 277 LEU B O   1 
ATOM   3578 C CB  . LEU B 1 277 ? 127.909 154.547 147.306 1.00 33.74  ? 277 LEU B CB  1 
ATOM   3579 C CG  . LEU B 1 277 ? 127.299 153.722 148.436 1.00 36.25  ? 277 LEU B CG  1 
ATOM   3580 C CD1 . LEU B 1 277 ? 125.886 154.191 148.699 1.00 40.18  ? 277 LEU B CD1 1 
ATOM   3581 C CD2 . LEU B 1 277 ? 127.330 152.244 148.106 1.00 26.89  ? 277 LEU B CD2 1 
ATOM   3582 N N   . LEU B 1 278 ? 130.167 156.109 145.649 1.00 33.34  ? 278 LEU B N   1 
ATOM   3583 C CA  . LEU B 1 278 ? 130.592 156.796 144.431 1.00 30.67  ? 278 LEU B CA  1 
ATOM   3584 C C   . LEU B 1 278 ? 131.803 156.118 143.798 1.00 27.69  ? 278 LEU B C   1 
ATOM   3585 O O   . LEU B 1 278 ? 131.866 155.965 142.571 1.00 28.93  ? 278 LEU B O   1 
ATOM   3586 C CB  . LEU B 1 278 ? 130.897 158.262 144.725 1.00 36.77  ? 278 LEU B CB  1 
ATOM   3587 C CG  . LEU B 1 278 ? 131.294 159.084 143.497 1.00 41.31  ? 278 LEU B CG  1 
ATOM   3588 C CD1 . LEU B 1 278 ? 130.133 159.188 142.525 1.00 41.89  ? 278 LEU B CD1 1 
ATOM   3589 C CD2 . LEU B 1 278 ? 131.788 160.460 143.898 1.00 43.51  ? 278 LEU B CD2 1 
ATOM   3590 N N   . ILE B 1 279 ? 132.775 155.705 144.614 1.00 28.29  ? 279 ILE B N   1 
ATOM   3591 C CA  . ILE B 1 279 ? 133.956 155.027 144.078 1.00 26.77  ? 279 ILE B CA  1 
ATOM   3592 C C   . ILE B 1 279 ? 133.572 153.689 143.458 1.00 22.43  ? 279 ILE B C   1 
ATOM   3593 O O   . ILE B 1 279 ? 134.050 153.324 142.374 1.00 26.89  ? 279 ILE B O   1 
ATOM   3594 C CB  . ILE B 1 279 ? 135.017 154.856 145.178 1.00 29.87  ? 279 ILE B CB  1 
ATOM   3595 C CG1 . ILE B 1 279 ? 135.476 156.220 145.683 1.00 31.64  ? 279 ILE B CG1 1 
ATOM   3596 C CG2 . ILE B 1 279 ? 136.198 154.057 144.663 1.00 25.94  ? 279 ILE B CG2 1 
ATOM   3597 C CD1 . ILE B 1 279 ? 136.046 156.174 147.064 1.00 36.52  ? 279 ILE B CD1 1 
ATOM   3598 N N   . GLU B 1 280 ? 132.711 152.932 144.141 1.00 23.22  ? 280 GLU B N   1 
ATOM   3599 C CA  . GLU B 1 280 ? 132.224 151.672 143.594 1.00 23.75  ? 280 GLU B CA  1 
ATOM   3600 C C   . GLU B 1 280 ? 131.462 151.896 142.298 1.00 21.96  ? 280 GLU B C   1 
ATOM   3601 O O   . GLU B 1 280 ? 131.594 151.115 141.350 1.00 23.09  ? 280 GLU B O   1 
ATOM   3602 C CB  . GLU B 1 280 ? 131.337 150.970 144.618 1.00 22.28  ? 280 GLU B CB  1 
ATOM   3603 C CG  . GLU B 1 280 ? 130.542 149.815 144.058 1.00 25.90  ? 280 GLU B CG  1 
ATOM   3604 C CD  . GLU B 1 280 ? 129.486 149.326 145.017 1.00 33.13  ? 280 GLU B CD  1 
ATOM   3605 O OE1 . GLU B 1 280 ? 129.391 149.886 146.126 1.00 40.12  ? 280 GLU B OE1 1 
ATOM   3606 O OE2 . GLU B 1 280 ? 128.751 148.382 144.664 1.00 33.72  ? 280 GLU B OE2 1 
ATOM   3607 N N   . PHE B 1 281 ? 130.655 152.956 142.242 1.00 21.61  ? 281 PHE B N   1 
ATOM   3608 C CA  . PHE B 1 281 ? 129.920 153.272 141.028 1.00 18.55  ? 281 PHE B CA  1 
ATOM   3609 C C   . PHE B 1 281 ? 130.865 153.581 139.879 1.00 20.28  ? 281 PHE B C   1 
ATOM   3610 O O   . PHE B 1 281 ? 130.636 153.142 138.751 1.00 21.87  ? 281 PHE B O   1 
ATOM   3611 C CB  . PHE B 1 281 ? 128.976 154.446 141.283 1.00 21.28  ? 281 PHE B CB  1 
ATOM   3612 C CG  . PHE B 1 281 ? 128.170 154.844 140.085 1.00 26.19  ? 281 PHE B CG  1 
ATOM   3613 C CD1 . PHE B 1 281 ? 127.093 154.080 139.678 1.00 30.69  ? 281 PHE B CD1 1 
ATOM   3614 C CD2 . PHE B 1 281 ? 128.486 155.983 139.368 1.00 26.25  ? 281 PHE B CD2 1 
ATOM   3615 C CE1 . PHE B 1 281 ? 126.351 154.440 138.578 1.00 31.22  ? 281 PHE B CE1 1 
ATOM   3616 C CE2 . PHE B 1 281 ? 127.748 156.347 138.268 1.00 29.73  ? 281 PHE B CE2 1 
ATOM   3617 C CZ  . PHE B 1 281 ? 126.680 155.575 137.872 1.00 35.59  ? 281 PHE B CZ  1 
ATOM   3618 N N   . LEU B 1 282 ? 131.940 154.327 140.146 1.00 19.53  ? 282 LEU B N   1 
ATOM   3619 C CA  . LEU B 1 282 ? 132.901 154.634 139.088 1.00 17.81  ? 282 LEU B CA  1 
ATOM   3620 C C   . LEU B 1 282 ? 133.627 153.382 138.605 1.00 20.58  ? 282 LEU B C   1 
ATOM   3621 O O   . LEU B 1 282 ? 133.851 153.213 137.400 1.00 26.45  ? 282 LEU B O   1 
ATOM   3622 C CB  . LEU B 1 282 ? 133.903 155.681 139.569 1.00 23.40  ? 282 LEU B CB  1 
ATOM   3623 C CG  . LEU B 1 282 ? 133.378 157.108 139.730 1.00 27.67  ? 282 LEU B CG  1 
ATOM   3624 C CD1 . LEU B 1 282 ? 134.495 158.038 140.167 1.00 20.73  ? 282 LEU B CD1 1 
ATOM   3625 C CD2 . LEU B 1 282 ? 132.745 157.591 138.439 1.00 31.35  ? 282 LEU B CD2 1 
ATOM   3626 N N   . PHE B 1 283 ? 134.004 152.493 139.526 1.00 19.26  ? 283 PHE B N   1 
ATOM   3627 C CA  . PHE B 1 283 ? 134.653 151.245 139.126 1.00 18.55  ? 283 PHE B CA  1 
ATOM   3628 C C   . PHE B 1 283 ? 133.722 150.385 138.276 1.00 19.88  ? 283 PHE B C   1 
ATOM   3629 O O   . PHE B 1 283 ? 134.101 149.899 137.199 1.00 24.01  ? 283 PHE B O   1 
ATOM   3630 C CB  . PHE B 1 283 ? 135.114 150.485 140.370 1.00 20.75  ? 283 PHE B CB  1 
ATOM   3631 C CG  . PHE B 1 283 ? 135.531 149.067 140.102 1.00 30.70  ? 283 PHE B CG  1 
ATOM   3632 C CD1 . PHE B 1 283 ? 136.650 148.789 139.339 1.00 31.24  ? 283 PHE B CD1 1 
ATOM   3633 C CD2 . PHE B 1 283 ? 134.813 148.010 140.633 1.00 30.76  ? 283 PHE B CD2 1 
ATOM   3634 C CE1 . PHE B 1 283 ? 137.034 147.483 139.100 1.00 30.00  ? 283 PHE B CE1 1 
ATOM   3635 C CE2 . PHE B 1 283 ? 135.195 146.704 140.399 1.00 26.11  ? 283 PHE B CE2 1 
ATOM   3636 C CZ  . PHE B 1 283 ? 136.308 146.442 139.633 1.00 25.89  ? 283 PHE B CZ  1 
ATOM   3637 N N   . LEU B 1 284 ? 132.487 150.198 138.738 1.00 18.28  ? 284 LEU B N   1 
ATOM   3638 C CA  . LEU B 1 284 ? 131.533 149.404 137.979 1.00 15.51  ? 284 LEU B CA  1 
ATOM   3639 C C   . LEU B 1 284 ? 131.160 150.079 136.666 1.00 16.90  ? 284 LEU B C   1 
ATOM   3640 O O   . LEU B 1 284 ? 130.824 149.398 135.697 1.00 19.61  ? 284 LEU B O   1 
ATOM   3641 C CB  . LEU B 1 284 ? 130.292 149.136 138.826 1.00 13.79  ? 284 LEU B CB  1 
ATOM   3642 C CG  . LEU B 1 284 ? 130.543 148.323 140.096 1.00 13.41  ? 284 LEU B CG  1 
ATOM   3643 C CD1 . LEU B 1 284 ? 129.252 148.081 140.845 1.00 16.45  ? 284 LEU B CD1 1 
ATOM   3644 C CD2 . LEU B 1 284 ? 131.229 147.013 139.762 1.00 13.73  ? 284 LEU B CD2 1 
ATOM   3645 N N   . LEU B 1 285 ? 131.239 151.407 136.602 1.00 15.48  ? 285 LEU B N   1 
ATOM   3646 C CA  . LEU B 1 285 ? 130.964 152.108 135.356 1.00 17.38  ? 285 LEU B CA  1 
ATOM   3647 C C   . LEU B 1 285 ? 132.100 151.940 134.359 1.00 20.85  ? 285 LEU B C   1 
ATOM   3648 O O   . LEU B 1 285 ? 131.857 151.863 133.151 1.00 21.87  ? 285 LEU B O   1 
ATOM   3649 C CB  . LEU B 1 285 ? 130.709 153.585 135.647 1.00 20.59  ? 285 LEU B CB  1 
ATOM   3650 C CG  . LEU B 1 285 ? 130.357 154.488 134.472 1.00 27.75  ? 285 LEU B CG  1 
ATOM   3651 C CD1 . LEU B 1 285 ? 129.030 154.080 133.867 1.00 25.87  ? 285 LEU B CD1 1 
ATOM   3652 C CD2 . LEU B 1 285 ? 130.319 155.926 134.932 1.00 33.52  ? 285 LEU B CD2 1 
ATOM   3653 N N   . GLY B 1 286 ? 133.342 151.887 134.838 1.00 20.71  ? 286 GLY B N   1 
ATOM   3654 C CA  . GLY B 1 286 ? 134.436 151.491 133.967 1.00 17.46  ? 286 GLY B CA  1 
ATOM   3655 C C   . GLY B 1 286 ? 134.255 150.084 133.432 1.00 21.18  ? 286 GLY B C   1 
ATOM   3656 O O   . GLY B 1 286 ? 134.523 149.812 132.257 1.00 29.49  ? 286 GLY B O   1 
ATOM   3657 N N   . ILE B 1 287 ? 133.784 149.171 134.285 1.00 20.85  ? 287 ILE B N   1 
ATOM   3658 C CA  . ILE B 1 287 ? 133.482 147.818 133.815 1.00 19.11  ? 287 ILE B CA  1 
ATOM   3659 C C   . ILE B 1 287 ? 132.372 147.849 132.767 1.00 21.99  ? 287 ILE B C   1 
ATOM   3660 O O   . ILE B 1 287 ? 132.415 147.114 131.774 1.00 27.55  ? 287 ILE B O   1 
ATOM   3661 C CB  . ILE B 1 287 ? 133.118 146.899 134.993 1.00 17.07  ? 287 ILE B CB  1 
ATOM   3662 C CG1 . ILE B 1 287 ? 134.291 146.770 135.958 1.00 15.81  ? 287 ILE B CG1 1 
ATOM   3663 C CG2 . ILE B 1 287 ? 132.727 145.527 134.488 1.00 15.76  ? 287 ILE B CG2 1 
ATOM   3664 C CD1 . ILE B 1 287 ? 134.047 145.774 137.054 1.00 15.14  ? 287 ILE B CD1 1 
ATOM   3665 N N   . ASN B 1 288 ? 131.355 148.687 132.980 1.00 18.91  ? 288 ASN B N   1 
ATOM   3666 C CA  . ASN B 1 288 ? 130.282 148.829 132.000 1.00 17.05  ? 288 ASN B CA  1 
ATOM   3667 C C   . ASN B 1 288 ? 130.812 149.339 130.671 1.00 23.29  ? 288 ASN B C   1 
ATOM   3668 O O   . ASN B 1 288 ? 130.399 148.865 129.610 1.00 28.52  ? 288 ASN B O   1 
ATOM   3669 C CB  . ASN B 1 288 ? 129.202 149.777 132.519 1.00 17.77  ? 288 ASN B CB  1 
ATOM   3670 C CG  . ASN B 1 288 ? 128.311 149.142 133.554 1.00 18.40  ? 288 ASN B CG  1 
ATOM   3671 O OD1 . ASN B 1 288 ? 128.180 149.650 134.661 1.00 21.82  ? 288 ASN B OD1 1 
ATOM   3672 N ND2 . ASN B 1 288 ? 127.679 148.037 133.196 1.00 19.84  ? 288 ASN B ND2 1 
ATOM   3673 N N   . THR B 1 289 ? 131.703 150.331 130.709 1.00 26.76  ? 289 THR B N   1 
ATOM   3674 C CA  . THR B 1 289 ? 132.287 150.854 129.478 1.00 25.05  ? 289 THR B CA  1 
ATOM   3675 C C   . THR B 1 289 ? 133.073 149.776 128.746 1.00 28.89  ? 289 THR B C   1 
ATOM   3676 O O   . THR B 1 289 ? 132.975 149.647 127.519 1.00 35.98  ? 289 THR B O   1 
ATOM   3677 C CB  . THR B 1 289 ? 133.185 152.049 129.787 1.00 25.37  ? 289 THR B CB  1 
ATOM   3678 O OG1 . THR B 1 289 ? 132.441 153.034 130.510 1.00 34.98  ? 289 THR B OG1 1 
ATOM   3679 C CG2 . THR B 1 289 ? 133.708 152.664 128.505 1.00 35.40  ? 289 THR B CG2 1 
ATOM   3680 N N   . TYR B 1 290 ? 133.854 148.986 129.487 1.00 26.03  ? 290 TYR B N   1 
ATOM   3681 C CA  . TYR B 1 290 ? 134.583 147.886 128.865 1.00 28.05  ? 290 TYR B CA  1 
ATOM   3682 C C   . TYR B 1 290 ? 133.631 146.883 128.227 1.00 32.68  ? 290 TYR B C   1 
ATOM   3683 O O   . TYR B 1 290 ? 133.863 146.426 127.102 1.00 40.72  ? 290 TYR B O   1 
ATOM   3684 C CB  . TYR B 1 290 ? 135.472 147.190 129.892 1.00 31.27  ? 290 TYR B CB  1 
ATOM   3685 C CG  . TYR B 1 290 ? 136.106 145.923 129.368 1.00 32.57  ? 290 TYR B CG  1 
ATOM   3686 C CD1 . TYR B 1 290 ? 137.187 145.973 128.502 1.00 31.91  ? 290 TYR B CD1 1 
ATOM   3687 C CD2 . TYR B 1 290 ? 135.621 144.678 129.737 1.00 33.72  ? 290 TYR B CD2 1 
ATOM   3688 C CE1 . TYR B 1 290 ? 137.767 144.823 128.023 1.00 39.15  ? 290 TYR B CE1 1 
ATOM   3689 C CE2 . TYR B 1 290 ? 136.194 143.521 129.259 1.00 39.64  ? 290 TYR B CE2 1 
ATOM   3690 C CZ  . TYR B 1 290 ? 137.267 143.599 128.402 1.00 44.50  ? 290 TYR B CZ  1 
ATOM   3691 O OH  . TYR B 1 290 ? 137.845 142.448 127.923 1.00 55.99  ? 290 TYR B OH  1 
ATOM   3692 N N   . GLY B 1 291 ? 132.558 146.526 128.933 1.00 31.56  ? 291 GLY B N   1 
ATOM   3693 C CA  . GLY B 1 291 ? 131.602 145.579 128.382 1.00 26.91  ? 291 GLY B CA  1 
ATOM   3694 C C   . GLY B 1 291 ? 130.898 146.106 127.147 1.00 31.62  ? 291 GLY B C   1 
ATOM   3695 O O   . GLY B 1 291 ? 130.675 145.368 126.185 1.00 39.10  ? 291 GLY B O   1 
ATOM   3696 N N   . TRP B 1 292 ? 130.534 147.389 127.157 1.00 29.57  ? 292 TRP B N   1 
ATOM   3697 C CA  . TRP B 1 292 ? 129.906 147.989 125.986 1.00 33.90  ? 292 TRP B CA  1 
ATOM   3698 C C   . TRP B 1 292 ? 130.854 147.991 124.797 1.00 41.74  ? 292 TRP B C   1 
ATOM   3699 O O   . TRP B 1 292 ? 130.447 147.691 123.669 1.00 46.11  ? 292 TRP B O   1 
ATOM   3700 C CB  . TRP B 1 292 ? 129.454 149.416 126.293 1.00 34.53  ? 292 TRP B CB  1 
ATOM   3701 C CG  . TRP B 1 292 ? 128.446 149.528 127.385 1.00 32.38  ? 292 TRP B CG  1 
ATOM   3702 C CD1 . TRP B 1 292 ? 127.549 148.583 127.775 1.00 30.99  ? 292 TRP B CD1 1 
ATOM   3703 C CD2 . TRP B 1 292 ? 128.239 150.655 128.241 1.00 30.26  ? 292 TRP B CD2 1 
ATOM   3704 N NE1 . TRP B 1 292 ? 126.793 149.050 128.818 1.00 27.40  ? 292 TRP B NE1 1 
ATOM   3705 C CE2 . TRP B 1 292 ? 127.198 150.322 129.124 1.00 31.91  ? 292 TRP B CE2 1 
ATOM   3706 C CE3 . TRP B 1 292 ? 128.834 151.915 128.345 1.00 28.39  ? 292 TRP B CE3 1 
ATOM   3707 C CZ2 . TRP B 1 292 ? 126.739 151.200 130.098 1.00 35.18  ? 292 TRP B CZ2 1 
ATOM   3708 C CZ3 . TRP B 1 292 ? 128.378 152.784 129.312 1.00 27.32  ? 292 TRP B CZ3 1 
ATOM   3709 C CH2 . TRP B 1 292 ? 127.340 152.424 130.175 1.00 30.67  ? 292 TRP B CH2 1 
ATOM   3710 N N   . ARG B 1 293 ? 132.124 148.338 125.025 1.00 43.26  ? 293 ARG B N   1 
ATOM   3711 C CA  . ARG B 1 293 ? 133.079 148.372 123.923 1.00 44.15  ? 293 ARG B CA  1 
ATOM   3712 C C   . ARG B 1 293 ? 133.339 146.976 123.372 1.00 43.97  ? 293 ARG B C   1 
ATOM   3713 O O   . ARG B 1 293 ? 133.429 146.791 122.153 1.00 48.52  ? 293 ARG B O   1 
ATOM   3714 C CB  . ARG B 1 293 ? 134.382 149.028 124.376 1.00 46.89  ? 293 ARG B CB  1 
ATOM   3715 C CG  . ARG B 1 293 ? 135.398 149.222 123.262 1.00 55.43  ? 293 ARG B CG  1 
ATOM   3716 C CD  . ARG B 1 293 ? 136.132 150.543 123.419 1.00 70.95  ? 293 ARG B CD  1 
ATOM   3717 N NE  . ARG B 1 293 ? 135.263 151.683 123.150 1.00 77.87  ? 293 ARG B NE  1 
ATOM   3718 C CZ  . ARG B 1 293 ? 135.558 152.940 123.452 1.00 73.24  ? 293 ARG B CZ  1 
ATOM   3719 N NH1 . ARG B 1 293 ? 136.686 153.257 124.064 1.00 68.18  ? 293 ARG B NH1 1 
ATOM   3720 N NH2 . ARG B 1 293 ? 134.697 153.902 123.136 1.00 75.34  ? 293 ARG B NH2 1 
ATOM   3721 N N   . GLN B 1 294 ? 133.462 145.981 124.251 1.00 36.62  ? 294 GLN B N   1 
ATOM   3722 C CA  . GLN B 1 294 ? 133.698 144.617 123.788 1.00 37.02  ? 294 GLN B CA  1 
ATOM   3723 C C   . GLN B 1 294 ? 132.488 144.058 123.050 1.00 47.77  ? 294 GLN B C   1 
ATOM   3724 O O   . GLN B 1 294 ? 132.640 143.346 122.052 1.00 56.44  ? 294 GLN B O   1 
ATOM   3725 C CB  . GLN B 1 294 ? 134.067 143.719 124.966 1.00 35.58  ? 294 GLN B CB  1 
ATOM   3726 C CG  . GLN B 1 294 ? 135.454 143.974 125.511 1.00 42.02  ? 294 GLN B CG  1 
ATOM   3727 C CD  . GLN B 1 294 ? 136.537 143.744 124.476 1.00 53.30  ? 294 GLN B CD  1 
ATOM   3728 O OE1 . GLN B 1 294 ? 136.717 142.629 123.988 1.00 56.95  ? 294 GLN B OE1 1 
ATOM   3729 N NE2 . GLN B 1 294 ? 137.263 144.801 124.134 1.00 51.14  ? 294 GLN B NE2 1 
ATOM   3730 N N   . ALA B 1 295 ? 131.281 144.363 123.526 1.00 43.95  ? 295 ALA B N   1 
ATOM   3731 C CA  . ALA B 1 295 ? 130.074 143.797 122.939 1.00 42.72  ? 295 ALA B CA  1 
ATOM   3732 C C   . ALA B 1 295 ? 129.589 144.556 121.713 1.00 46.64  ? 295 ALA B C   1 
ATOM   3733 O O   . ALA B 1 295 ? 128.628 144.115 121.074 1.00 48.17  ? 295 ALA B O   1 
ATOM   3734 C CB  . ALA B 1 295 ? 128.959 143.750 123.983 1.00 44.92  ? 295 ALA B CB  1 
ATOM   3735 N N   . GLY B 1 296 ? 130.222 145.672 121.366 1.00 45.44  ? 296 GLY B N   1 
ATOM   3736 C CA  . GLY B 1 296 ? 129.799 146.448 120.222 1.00 42.82  ? 296 GLY B CA  1 
ATOM   3737 C C   . GLY B 1 296 ? 128.682 147.427 120.488 1.00 47.81  ? 296 GLY B C   1 
ATOM   3738 O O   . GLY B 1 296 ? 128.182 148.041 119.539 1.00 54.93  ? 296 GLY B O   1 
ATOM   3739 N N   . VAL B 1 297 ? 128.272 147.594 121.742 1.00 46.49  ? 297 VAL B N   1 
ATOM   3740 C CA  . VAL B 1 297 ? 127.227 148.553 122.088 1.00 45.96  ? 297 VAL B CA  1 
ATOM   3741 C C   . VAL B 1 297 ? 127.803 149.956 121.930 1.00 53.68  ? 297 VAL B C   1 
ATOM   3742 O O   . VAL B 1 297 ? 128.660 150.376 122.711 1.00 59.90  ? 297 VAL B O   1 
ATOM   3743 C CB  . VAL B 1 297 ? 126.701 148.323 123.508 1.00 41.86  ? 297 VAL B CB  1 
ATOM   3744 C CG1 . VAL B 1 297 ? 125.672 149.377 123.865 1.00 45.52  ? 297 VAL B CG1 1 
ATOM   3745 C CG2 . VAL B 1 297 ? 126.112 146.932 123.633 1.00 43.60  ? 297 VAL B CG2 1 
ATOM   3746 N N   . ASN B 1 298 ? 127.330 150.686 120.921 1.00 52.32  ? 298 ASN B N   1 
ATOM   3747 C CA  . ASN B 1 298 ? 127.859 152.012 120.603 1.00 50.11  ? 298 ASN B CA  1 
ATOM   3748 C C   . ASN B 1 298 ? 127.305 153.011 121.614 1.00 52.75  ? 298 ASN B C   1 
ATOM   3749 O O   . ASN B 1 298 ? 126.343 153.739 121.360 1.00 60.69  ? 298 ASN B O   1 
ATOM   3750 C CB  . ASN B 1 298 ? 127.504 152.398 119.174 1.00 52.82  ? 298 ASN B CB  1 
ATOM   3751 C CG  . ASN B 1 298 ? 128.329 153.561 118.660 1.00 62.98  ? 298 ASN B CG  1 
ATOM   3752 O OD1 . ASN B 1 298 ? 128.798 154.396 119.431 1.00 66.57  ? 298 ASN B OD1 1 
ATOM   3753 N ND2 . ASN B 1 298 ? 128.509 153.621 117.347 1.00 63.72  ? 298 ASN B ND2 1 
ATOM   3754 N N   . HIS B 1 299 ? 127.934 153.042 122.791 1.00 52.08  ? 299 HIS B N   1 
ATOM   3755 C CA  . HIS B 1 299 ? 127.504 153.967 123.833 1.00 47.02  ? 299 HIS B CA  1 
ATOM   3756 C C   . HIS B 1 299 ? 127.856 155.411 123.506 1.00 52.63  ? 299 HIS B C   1 
ATOM   3757 O O   . HIS B 1 299 ? 127.194 156.322 124.008 1.00 55.17  ? 299 HIS B O   1 
ATOM   3758 C CB  . HIS B 1 299 ? 128.115 153.578 125.179 1.00 43.76  ? 299 HIS B CB  1 
ATOM   3759 C CG  . HIS B 1 299 ? 129.586 153.839 125.275 1.00 52.82  ? 299 HIS B CG  1 
ATOM   3760 N ND1 . HIS B 1 299 ? 130.528 153.002 124.718 1.00 55.63  ? 299 HIS B ND1 1 
ATOM   3761 C CD2 . HIS B 1 299 ? 130.276 154.838 125.872 1.00 49.72  ? 299 HIS B CD2 1 
ATOM   3762 C CE1 . HIS B 1 299 ? 131.735 153.478 124.963 1.00 56.32  ? 299 HIS B CE1 1 
ATOM   3763 N NE2 . HIS B 1 299 ? 131.610 154.591 125.661 1.00 55.66  ? 299 HIS B NE2 1 
ATOM   3764 N N   . VAL B 1 300 ? 128.881 155.639 122.685 1.00 56.27  ? 300 VAL B N   1 
ATOM   3765 C CA  . VAL B 1 300 ? 129.235 157.002 122.304 1.00 57.44  ? 300 VAL B CA  1 
ATOM   3766 C C   . VAL B 1 300 ? 128.124 157.628 121.473 1.00 58.84  ? 300 VAL B C   1 
ATOM   3767 O O   . VAL B 1 300 ? 127.833 158.823 121.597 1.00 60.99  ? 300 VAL B O   1 
ATOM   3768 C CB  . VAL B 1 300 ? 130.578 157.015 121.553 1.00 60.81  ? 300 VAL B CB  1 
ATOM   3769 C CG1 . VAL B 1 300 ? 131.004 158.441 121.250 1.00 63.79  ? 300 VAL B CG1 1 
ATOM   3770 C CG2 . VAL B 1 300 ? 131.641 156.294 122.359 1.00 64.33  ? 300 VAL B CG2 1 
ATOM   3771 N N   . LEU B 1 301 ? 127.488 156.834 120.611 1.00 57.97  ? 301 LEU B N   1 
ATOM   3772 C CA  . LEU B 1 301 ? 126.415 157.360 119.775 1.00 57.44  ? 301 LEU B CA  1 
ATOM   3773 C C   . LEU B 1 301 ? 125.194 157.725 120.610 1.00 55.67  ? 301 LEU B C   1 
ATOM   3774 O O   . LEU B 1 301 ? 124.645 158.824 120.474 1.00 60.93  ? 301 LEU B O   1 
ATOM   3775 C CB  . LEU B 1 301 ? 126.045 156.340 118.699 1.00 52.84  ? 301 LEU B CB  1 
ATOM   3776 C CG  . LEU B 1 301 ? 124.971 156.774 117.701 1.00 53.35  ? 301 LEU B CG  1 
ATOM   3777 C CD1 . LEU B 1 301 ? 125.477 157.912 116.834 1.00 58.73  ? 301 LEU B CD1 1 
ATOM   3778 C CD2 . LEU B 1 301 ? 124.525 155.600 116.847 1.00 55.54  ? 301 LEU B CD2 1 
ATOM   3779 N N   . ILE B 1 302 ? 124.754 156.817 121.483 1.00 51.80  ? 302 ILE B N   1 
ATOM   3780 C CA  . ILE B 1 302 ? 123.526 157.062 122.232 1.00 56.04  ? 302 ILE B CA  1 
ATOM   3781 C C   . ILE B 1 302 ? 123.732 158.134 123.296 1.00 57.01  ? 302 ILE B C   1 
ATOM   3782 O O   . ILE B 1 302 ? 122.835 158.949 123.540 1.00 62.08  ? 302 ILE B O   1 
ATOM   3783 C CB  . ILE B 1 302 ? 122.987 155.750 122.830 1.00 52.25  ? 302 ILE B CB  1 
ATOM   3784 C CG1 . ILE B 1 302 ? 124.007 155.106 123.758 1.00 51.26  ? 302 ILE B CG1 1 
ATOM   3785 C CG2 . ILE B 1 302 ? 122.624 154.775 121.726 1.00 47.34  ? 302 ILE B CG2 1 
ATOM   3786 C CD1 . ILE B 1 302 ? 123.548 153.779 124.297 1.00 51.79  ? 302 ILE B CD1 1 
ATOM   3787 N N   . PHE B 1 303 ? 124.899 158.163 123.942 1.00 51.15  ? 303 PHE B N   1 
ATOM   3788 C CA  . PHE B 1 303 ? 125.195 159.203 124.920 1.00 51.22  ? 303 PHE B CA  1 
ATOM   3789 C C   . PHE B 1 303 ? 125.456 160.560 124.282 1.00 58.18  ? 303 PHE B C   1 
ATOM   3790 O O   . PHE B 1 303 ? 125.574 161.550 125.011 1.00 61.61  ? 303 PHE B O   1 
ATOM   3791 C CB  . PHE B 1 303 ? 126.406 158.816 125.772 1.00 50.46  ? 303 PHE B CB  1 
ATOM   3792 C CG  . PHE B 1 303 ? 126.074 157.963 126.961 1.00 51.50  ? 303 PHE B CG  1 
ATOM   3793 C CD1 . PHE B 1 303 ? 125.489 158.515 128.082 1.00 48.64  ? 303 PHE B CD1 1 
ATOM   3794 C CD2 . PHE B 1 303 ? 126.368 156.612 126.967 1.00 51.49  ? 303 PHE B CD2 1 
ATOM   3795 C CE1 . PHE B 1 303 ? 125.191 157.735 129.175 1.00 50.44  ? 303 PHE B CE1 1 
ATOM   3796 C CE2 . PHE B 1 303 ? 126.074 155.828 128.061 1.00 38.62  ? 303 PHE B CE2 1 
ATOM   3797 C CZ  . PHE B 1 303 ? 125.486 156.389 129.163 1.00 38.84  ? 303 PHE B CZ  1 
ATOM   3798 N N   . GLU B 1 304 ? 125.559 160.623 122.953 1.00 59.74  ? 304 GLU B N   1 
ATOM   3799 C CA  . GLU B 1 304 ? 125.843 161.864 122.231 1.00 63.97  ? 304 GLU B CA  1 
ATOM   3800 C C   . GLU B 1 304 ? 127.175 162.465 122.677 1.00 68.34  ? 304 GLU B C   1 
ATOM   3801 O O   . GLU B 1 304 ? 127.288 163.661 122.947 1.00 71.53  ? 304 GLU B O   1 
ATOM   3802 C CB  . GLU B 1 304 ? 124.701 162.871 122.394 1.00 69.02  ? 304 GLU B CB  1 
ATOM   3803 C CG  . GLU B 1 304 ? 123.332 162.321 122.026 1.00 70.01  ? 304 GLU B CG  1 
ATOM   3804 C CD  . GLU B 1 304 ? 122.310 162.510 123.133 1.00 76.51  ? 304 GLU B CD  1 
ATOM   3805 O OE1 . GLU B 1 304 ? 122.598 163.261 124.089 1.00 70.30  ? 304 GLU B OE1 1 
ATOM   3806 O OE2 . GLU B 1 304 ? 121.221 161.904 123.049 1.00 77.77  ? 304 GLU B OE2 1 
ATOM   3807 N N   . LEU B 1 305 ? 128.192 161.613 122.755 1.00 69.27  ? 305 LEU B N   1 
ATOM   3808 C CA  . LEU B 1 305 ? 129.528 162.032 123.143 1.00 72.33  ? 305 LEU B CA  1 
ATOM   3809 C C   . LEU B 1 305 ? 130.363 162.375 121.913 1.00 81.31  ? 305 LEU B C   1 
ATOM   3810 O O   . LEU B 1 305 ? 130.000 162.073 120.774 1.00 83.63  ? 305 LEU B O   1 
ATOM   3811 C CB  . LEU B 1 305 ? 130.222 160.938 123.955 1.00 69.67  ? 305 LEU B CB  1 
ATOM   3812 C CG  . LEU B 1 305 ? 129.583 160.500 125.269 1.00 58.32  ? 305 LEU B CG  1 
ATOM   3813 C CD1 . LEU B 1 305 ? 130.393 159.383 125.892 1.00 59.64  ? 305 LEU B CD1 1 
ATOM   3814 C CD2 . LEU B 1 305 ? 129.475 161.672 126.217 1.00 60.16  ? 305 LEU B CD2 1 
ATOM   3815 N N   . ASN B 1 306 ? 131.497 163.013 122.157 1.00 81.97  ? 306 ASN B N   1 
ATOM   3816 C CA  . ASN B 1 306 ? 132.448 163.294 121.090 1.00 86.58  ? 306 ASN B CA  1 
ATOM   3817 C C   . ASN B 1 306 ? 133.175 162.010 120.714 1.00 90.59  ? 306 ASN B C   1 
ATOM   3818 O O   . ASN B 1 306 ? 133.800 161.389 121.583 1.00 93.98  ? 306 ASN B O   1 
ATOM   3819 C CB  . ASN B 1 306 ? 133.442 164.361 121.536 1.00 87.20  ? 306 ASN B CB  1 
ATOM   3820 C CG  . ASN B 1 306 ? 134.463 164.693 120.468 1.00 94.87  ? 306 ASN B CG  1 
ATOM   3821 O OD1 . ASN B 1 306 ? 134.178 164.616 119.274 1.00 97.23  ? 306 ASN B OD1 1 
ATOM   3822 N ND2 . ASN B 1 306 ? 135.664 165.063 120.894 1.00 95.44  ? 306 ASN B ND2 1 
ATOM   3823 N N   . PRO B 1 307 ? 133.124 161.572 119.456 1.00 92.17  ? 307 PRO B N   1 
ATOM   3824 C CA  . PRO B 1 307 ? 133.791 160.326 119.065 1.00 91.73  ? 307 PRO B CA  1 
ATOM   3825 C C   . PRO B 1 307 ? 135.303 160.426 118.939 1.00 95.80  ? 307 PRO B C   1 
ATOM   3826 O O   . PRO B 1 307 ? 135.934 159.447 118.533 1.00 98.61  ? 307 PRO B O   1 
ATOM   3827 C CB  . PRO B 1 307 ? 133.153 160.018 117.701 1.00 91.55  ? 307 PRO B CB  1 
ATOM   3828 C CG  . PRO B 1 307 ? 132.780 161.346 117.162 1.00 94.85  ? 307 PRO B CG  1 
ATOM   3829 C CD  . PRO B 1 307 ? 132.358 162.165 118.346 1.00 92.89  ? 307 PRO B CD  1 
ATOM   3830 N N   . ARG B 1 308 ? 135.904 161.570 119.274 1.00 96.67  ? 308 ARG B N   1 
ATOM   3831 C CA  . ARG B 1 308 ? 137.346 161.740 119.182 1.00 100.04 ? 308 ARG B CA  1 
ATOM   3832 C C   . ARG B 1 308 ? 138.034 161.899 120.528 1.00 99.46  ? 308 ARG B C   1 
ATOM   3833 O O   . ARG B 1 308 ? 139.249 161.695 120.607 1.00 100.37 ? 308 ARG B O   1 
ATOM   3834 C CB  . ARG B 1 308 ? 137.685 162.960 118.313 1.00 102.13 ? 308 ARG B CB  1 
ATOM   3835 C CG  . ARG B 1 308 ? 137.216 162.846 116.873 1.00 98.51  ? 308 ARG B CG  1 
ATOM   3836 C CD  . ARG B 1 308 ? 137.845 161.646 116.186 1.00 106.55 ? 308 ARG B CD  1 
ATOM   3837 N NE  . ARG B 1 308 ? 137.383 161.502 114.811 1.00 108.62 ? 308 ARG B NE  1 
ATOM   3838 C CZ  . ARG B 1 308 ? 136.315 160.805 114.449 1.00 102.81 ? 308 ARG B CZ  1 
ATOM   3839 N NH1 . ARG B 1 308 ? 135.571 160.169 115.339 1.00 103.26 ? 308 ARG B NH1 1 
ATOM   3840 N NH2 . ARG B 1 308 ? 135.986 160.743 113.162 1.00 98.55  ? 308 ARG B NH2 1 
ATOM   3841 N N   . SER B 1 309 ? 137.297 162.253 121.583 1.00 97.68  ? 309 SER B N   1 
ATOM   3842 C CA  . SER B 1 309 ? 137.895 162.489 122.890 1.00 98.03  ? 309 SER B CA  1 
ATOM   3843 C C   . SER B 1 309 ? 137.059 161.877 124.008 1.00 94.45  ? 309 SER B C   1 
ATOM   3844 O O   . SER B 1 309 ? 137.007 162.421 125.117 1.00 87.22  ? 309 SER B O   1 
ATOM   3845 C CB  . SER B 1 309 ? 138.085 163.986 123.141 1.00 97.69  ? 309 SER B CB  1 
ATOM   3846 O OG  . SER B 1 309 ? 136.858 164.681 123.009 1.00 97.11  ? 309 SER B OG  1 
ATOM   3847 N N   . ASN B 1 310 ? 136.399 160.755 123.736 1.00 91.70  ? 310 ASN B N   1 
ATOM   3848 C CA  . ASN B 1 310 ? 135.579 160.098 124.741 1.00 84.66  ? 310 ASN B CA  1 
ATOM   3849 C C   . ASN B 1 310 ? 136.451 159.388 125.770 1.00 81.70  ? 310 ASN B C   1 
ATOM   3850 O O   . ASN B 1 310 ? 137.586 158.993 125.492 1.00 82.76  ? 310 ASN B O   1 
ATOM   3851 C CB  . ASN B 1 310 ? 134.619 159.100 124.090 1.00 80.58  ? 310 ASN B CB  1 
ATOM   3852 C CG  . ASN B 1 310 ? 135.335 157.908 123.486 1.00 85.46  ? 310 ASN B CG  1 
ATOM   3853 O OD1 . ASN B 1 310 ? 135.218 156.788 123.980 1.00 83.07  ? 310 ASN B OD1 1 
ATOM   3854 N ND2 . ASN B 1 310 ? 136.072 158.141 122.408 1.00 86.31  ? 310 ASN B ND2 1 
ATOM   3855 N N   . LEU B 1 311 ? 135.907 159.236 126.973 1.00 69.64  ? 311 LEU B N   1 
ATOM   3856 C CA  . LEU B 1 311 ? 136.642 158.601 128.058 1.00 58.07  ? 311 LEU B CA  1 
ATOM   3857 C C   . LEU B 1 311 ? 136.650 157.088 127.886 1.00 63.56  ? 311 LEU B C   1 
ATOM   3858 O O   . LEU B 1 311 ? 135.653 156.488 127.475 1.00 73.08  ? 311 LEU B O   1 
ATOM   3859 C CB  . LEU B 1 311 ? 136.018 158.971 129.402 1.00 56.21  ? 311 LEU B CB  1 
ATOM   3860 C CG  . LEU B 1 311 ? 136.958 159.075 130.600 1.00 58.11  ? 311 LEU B CG  1 
ATOM   3861 C CD1 . LEU B 1 311 ? 137.918 160.237 130.419 1.00 64.16  ? 311 LEU B CD1 1 
ATOM   3862 C CD2 . LEU B 1 311 ? 136.170 159.225 131.887 1.00 46.45  ? 311 LEU B CD2 1 
ATOM   3863 N N   . SER B 1 312 ? 137.782 156.471 128.204 1.00 57.83  ? 312 SER B N   1 
ATOM   3864 C CA  . SER B 1 312 ? 137.907 155.024 128.155 1.00 48.81  ? 312 SER B CA  1 
ATOM   3865 C C   . SER B 1 312 ? 137.683 154.430 129.541 1.00 42.17  ? 312 SER B C   1 
ATOM   3866 O O   . SER B 1 312 ? 137.599 155.140 130.544 1.00 41.52  ? 312 SER B O   1 
ATOM   3867 C CB  . SER B 1 312 ? 139.278 154.623 127.613 1.00 44.79  ? 312 SER B CB  1 
ATOM   3868 O OG  . SER B 1 312 ? 139.392 153.216 127.507 1.00 55.67  ? 312 SER B OG  1 
ATOM   3869 N N   . HIS B 1 313 ? 137.577 153.100 129.592 1.00 35.55  ? 313 HIS B N   1 
ATOM   3870 C CA  . HIS B 1 313 ? 137.398 152.441 130.880 1.00 33.61  ? 313 HIS B CA  1 
ATOM   3871 C C   . HIS B 1 313 ? 138.655 152.538 131.734 1.00 33.12  ? 313 HIS B C   1 
ATOM   3872 O O   . HIS B 1 313 ? 138.572 152.495 132.967 1.00 26.75  ? 313 HIS B O   1 
ATOM   3873 C CB  . HIS B 1 313 ? 136.983 150.982 130.679 1.00 31.37  ? 313 HIS B CB  1 
ATOM   3874 C CG  . HIS B 1 313 ? 138.021 150.130 130.019 1.00 36.20  ? 313 HIS B CG  1 
ATOM   3875 N ND1 . HIS B 1 313 ? 138.142 150.031 128.650 1.00 38.68  ? 313 HIS B ND1 1 
ATOM   3876 C CD2 . HIS B 1 313 ? 138.967 149.312 130.539 1.00 35.75  ? 313 HIS B CD2 1 
ATOM   3877 C CE1 . HIS B 1 313 ? 139.127 149.202 128.356 1.00 42.03  ? 313 HIS B CE1 1 
ATOM   3878 N NE2 . HIS B 1 313 ? 139.643 148.752 129.485 1.00 37.62  ? 313 HIS B NE2 1 
ATOM   3879 N N   . GLN B 1 314 ? 139.820 152.688 131.098 1.00 36.65  ? 314 GLN B N   1 
ATOM   3880 C CA  . GLN B 1 314 ? 141.058 152.902 131.838 1.00 32.35  ? 314 GLN B CA  1 
ATOM   3881 C C   . GLN B 1 314 ? 141.001 154.188 132.648 1.00 32.07  ? 314 GLN B C   1 
ATOM   3882 O O   . GLN B 1 314 ? 141.436 154.222 133.802 1.00 29.72  ? 314 GLN B O   1 
ATOM   3883 C CB  . GLN B 1 314 ? 142.242 152.938 130.876 1.00 36.12  ? 314 GLN B CB  1 
ATOM   3884 C CG  . GLN B 1 314 ? 142.497 151.640 130.141 1.00 40.44  ? 314 GLN B CG  1 
ATOM   3885 C CD  . GLN B 1 314 ? 143.274 150.648 130.973 1.00 38.84  ? 314 GLN B CD  1 
ATOM   3886 O OE1 . GLN B 1 314 ? 143.523 150.870 132.155 1.00 37.28  ? 314 GLN B OE1 1 
ATOM   3887 N NE2 . GLN B 1 314 ? 143.669 149.545 130.356 1.00 35.47  ? 314 GLN B NE2 1 
ATOM   3888 N N   . HIS B 1 315 ? 140.463 155.258 132.062 1.00 35.02  ? 315 HIS B N   1 
ATOM   3889 C CA  . HIS B 1 315 ? 140.398 156.527 132.773 1.00 28.57  ? 315 HIS B CA  1 
ATOM   3890 C C   . HIS B 1 315 ? 139.375 156.493 133.900 1.00 28.52  ? 315 HIS B C   1 
ATOM   3891 O O   . HIS B 1 315 ? 139.586 157.120 134.944 1.00 33.06  ? 315 HIS B O   1 
ATOM   3892 C CB  . HIS B 1 315 ? 140.094 157.650 131.790 1.00 32.43  ? 315 HIS B CB  1 
ATOM   3893 C CG  . HIS B 1 315 ? 141.069 157.731 130.658 1.00 44.40  ? 315 HIS B CG  1 
ATOM   3894 N ND1 . HIS B 1 315 ? 140.907 157.026 129.485 1.00 49.45  ? 315 HIS B ND1 1 
ATOM   3895 C CD2 . HIS B 1 315 ? 142.225 158.421 130.524 1.00 48.94  ? 315 HIS B CD2 1 
ATOM   3896 C CE1 . HIS B 1 315 ? 141.917 157.286 128.675 1.00 51.34  ? 315 HIS B CE1 1 
ATOM   3897 N NE2 . HIS B 1 315 ? 142.730 158.130 129.281 1.00 55.64  ? 315 HIS B NE2 1 
ATOM   3898 N N   . LEU B 1 316 ? 138.268 155.772 133.717 1.00 28.25  ? 316 LEU B N   1 
ATOM   3899 C CA  . LEU B 1 316 ? 137.330 155.577 134.818 1.00 25.32  ? 316 LEU B CA  1 
ATOM   3900 C C   . LEU B 1 316 ? 137.965 154.781 135.949 1.00 23.08  ? 316 LEU B C   1 
ATOM   3901 O O   . LEU B 1 316 ? 137.773 155.105 137.127 1.00 19.71  ? 316 LEU B O   1 
ATOM   3902 C CB  . LEU B 1 316 ? 136.065 154.889 134.312 1.00 24.04  ? 316 LEU B CB  1 
ATOM   3903 C CG  . LEU B 1 316 ? 135.080 155.797 133.576 1.00 24.22  ? 316 LEU B CG  1 
ATOM   3904 C CD1 . LEU B 1 316 ? 134.041 154.983 132.841 1.00 27.18  ? 316 LEU B CD1 1 
ATOM   3905 C CD2 . LEU B 1 316 ? 134.418 156.745 134.555 1.00 24.17  ? 316 LEU B CD2 1 
ATOM   3906 N N   . PHE B 1 317 ? 138.731 153.740 135.613 1.00 27.67  ? 317 PHE B N   1 
ATOM   3907 C CA  . PHE B 1 317 ? 139.471 153.007 136.636 1.00 25.37  ? 317 PHE B CA  1 
ATOM   3908 C C   . PHE B 1 317 ? 140.473 153.910 137.340 1.00 23.00  ? 317 PHE B C   1 
ATOM   3909 O O   . PHE B 1 317 ? 140.678 153.795 138.551 1.00 26.08  ? 317 PHE B O   1 
ATOM   3910 C CB  . PHE B 1 317 ? 140.182 151.805 136.015 1.00 23.31  ? 317 PHE B CB  1 
ATOM   3911 C CG  . PHE B 1 317 ? 139.257 150.699 135.597 1.00 23.56  ? 317 PHE B CG  1 
ATOM   3912 C CD1 . PHE B 1 317 ? 138.084 150.462 136.283 1.00 21.31  ? 317 PHE B CD1 1 
ATOM   3913 C CD2 . PHE B 1 317 ? 139.566 149.896 134.515 1.00 26.69  ? 317 PHE B CD2 1 
ATOM   3914 C CE1 . PHE B 1 317 ? 137.239 149.447 135.898 1.00 22.41  ? 317 PHE B CE1 1 
ATOM   3915 C CE2 . PHE B 1 317 ? 138.720 148.880 134.127 1.00 25.65  ? 317 PHE B CE2 1 
ATOM   3916 C CZ  . PHE B 1 317 ? 137.558 148.656 134.820 1.00 23.10  ? 317 PHE B CZ  1 
ATOM   3917 N N   . GLU B 1 318 ? 141.104 154.815 136.594 1.00 26.29  ? 318 GLU B N   1 
ATOM   3918 C CA  . GLU B 1 318 ? 142.059 155.754 137.176 1.00 28.73  ? 318 GLU B CA  1 
ATOM   3919 C C   . GLU B 1 318 ? 141.384 156.692 138.170 1.00 30.39  ? 318 GLU B C   1 
ATOM   3920 O O   . GLU B 1 318 ? 141.886 156.907 139.280 1.00 33.47  ? 318 GLU B O   1 
ATOM   3921 C CB  . GLU B 1 318 ? 142.723 156.552 136.057 1.00 26.05  ? 318 GLU B CB  1 
ATOM   3922 C CG  . GLU B 1 318 ? 144.222 156.655 136.137 1.00 27.88  ? 318 GLU B CG  1 
ATOM   3923 C CD  . GLU B 1 318 ? 144.790 157.389 134.946 1.00 42.74  ? 318 GLU B CD  1 
ATOM   3924 O OE1 . GLU B 1 318 ? 143.997 157.856 134.105 1.00 46.97  ? 318 GLU B OE1 1 
ATOM   3925 O OE2 . GLU B 1 318 ? 146.025 157.501 134.844 1.00 50.15  ? 318 GLU B OE2 1 
ATOM   3926 N N   . ILE B 1 319 ? 140.247 157.271 137.778 1.00 23.67  ? 319 ILE B N   1 
ATOM   3927 C CA  . ILE B 1 319 ? 139.516 158.172 138.668 1.00 23.54  ? 319 ILE B CA  1 
ATOM   3928 C C   . ILE B 1 319 ? 139.054 157.425 139.911 1.00 26.38  ? 319 ILE B C   1 
ATOM   3929 O O   . ILE B 1 319 ? 139.178 157.919 141.039 1.00 30.63  ? 319 ILE B O   1 
ATOM   3930 C CB  . ILE B 1 319 ? 138.327 158.810 137.930 1.00 23.39  ? 319 ILE B CB  1 
ATOM   3931 C CG1 . ILE B 1 319 ? 138.809 159.621 136.731 1.00 26.33  ? 319 ILE B CG1 1 
ATOM   3932 C CG2 . ILE B 1 319 ? 137.531 159.687 138.872 1.00 29.50  ? 319 ILE B CG2 1 
ATOM   3933 C CD1 . ILE B 1 319 ? 137.693 160.076 135.828 1.00 27.13  ? 319 ILE B CD1 1 
ATOM   3934 N N   . ALA B 1 320 ? 138.503 156.224 139.720 1.00 23.91  ? 320 ALA B N   1 
ATOM   3935 C CA  . ALA B 1 320 ? 138.041 155.432 140.851 1.00 20.51  ? 320 ALA B CA  1 
ATOM   3936 C C   . ALA B 1 320 ? 139.189 155.093 141.789 1.00 25.99  ? 320 ALA B C   1 
ATOM   3937 O O   . ALA B 1 320 ? 139.038 155.168 143.011 1.00 32.67  ? 320 ALA B O   1 
ATOM   3938 C CB  . ALA B 1 320 ? 137.359 154.160 140.354 1.00 19.71  ? 320 ALA B CB  1 
ATOM   3939 N N   . GLY B 1 321 ? 140.348 154.727 141.240 1.00 24.14  ? 321 GLY B N   1 
ATOM   3940 C CA  . GLY B 1 321 ? 141.483 154.393 142.082 1.00 19.66  ? 321 GLY B CA  1 
ATOM   3941 C C   . GLY B 1 321 ? 142.011 155.582 142.856 1.00 31.49  ? 321 GLY B C   1 
ATOM   3942 O O   . GLY B 1 321 ? 142.327 155.467 144.041 1.00 35.82  ? 321 GLY B O   1 
ATOM   3943 N N   . PHE B 1 322 ? 142.105 156.743 142.205 1.00 30.99  ? 322 PHE B N   1 
ATOM   3944 C CA  . PHE B 1 322 ? 142.584 157.939 142.893 1.00 27.58  ? 322 PHE B CA  1 
ATOM   3945 C C   . PHE B 1 322 ? 141.626 158.359 144.004 1.00 34.91  ? 322 PHE B C   1 
ATOM   3946 O O   . PHE B 1 322 ? 142.048 158.657 145.132 1.00 37.44  ? 322 PHE B O   1 
ATOM   3947 C CB  . PHE B 1 322 ? 142.782 159.069 141.885 1.00 28.04  ? 322 PHE B CB  1 
ATOM   3948 C CG  . PHE B 1 322 ? 143.348 160.320 142.482 1.00 44.79  ? 322 PHE B CG  1 
ATOM   3949 C CD1 . PHE B 1 322 ? 144.603 160.315 143.067 1.00 44.58  ? 322 PHE B CD1 1 
ATOM   3950 C CD2 . PHE B 1 322 ? 142.632 161.504 142.452 1.00 46.66  ? 322 PHE B CD2 1 
ATOM   3951 C CE1 . PHE B 1 322 ? 145.128 161.464 143.619 1.00 48.53  ? 322 PHE B CE1 1 
ATOM   3952 C CE2 . PHE B 1 322 ? 143.154 162.657 143.001 1.00 51.57  ? 322 PHE B CE2 1 
ATOM   3953 C CZ  . PHE B 1 322 ? 144.403 162.637 143.585 1.00 53.67  ? 322 PHE B CZ  1 
ATOM   3954 N N   . LEU B 1 323 ? 140.323 158.370 143.709 1.00 33.77  ? 323 LEU B N   1 
ATOM   3955 C CA  . LEU B 1 323 ? 139.350 158.737 144.729 1.00 29.67  ? 323 LEU B CA  1 
ATOM   3956 C C   . LEU B 1 323 ? 139.300 157.708 145.849 1.00 28.96  ? 323 LEU B C   1 
ATOM   3957 O O   . LEU B 1 323 ? 139.099 158.074 147.009 1.00 33.77  ? 323 LEU B O   1 
ATOM   3958 C CB  . LEU B 1 323 ? 137.969 158.925 144.105 1.00 30.59  ? 323 LEU B CB  1 
ATOM   3959 C CG  . LEU B 1 323 ? 137.835 160.093 143.123 1.00 36.97  ? 323 LEU B CG  1 
ATOM   3960 C CD1 . LEU B 1 323 ? 136.378 160.355 142.794 1.00 38.98  ? 323 LEU B CD1 1 
ATOM   3961 C CD2 . LEU B 1 323 ? 138.496 161.349 143.666 1.00 41.99  ? 323 LEU B CD2 1 
ATOM   3962 N N   . GLY B 1 324 ? 139.490 156.426 145.533 1.00 26.30  ? 324 GLY B N   1 
ATOM   3963 C CA  . GLY B 1 324 ? 139.574 155.421 146.574 1.00 27.31  ? 324 GLY B CA  1 
ATOM   3964 C C   . GLY B 1 324 ? 140.797 155.577 147.447 1.00 31.87  ? 324 GLY B C   1 
ATOM   3965 O O   . GLY B 1 324 ? 140.735 155.327 148.652 1.00 38.73  ? 324 GLY B O   1 
ATOM   3966 N N   . ILE B 1 325 ? 141.923 155.983 146.860 1.00 30.37  ? 325 ILE B N   1 
ATOM   3967 C CA  . ILE B 1 325 ? 143.115 156.258 147.655 1.00 31.35  ? 325 ILE B CA  1 
ATOM   3968 C C   . ILE B 1 325 ? 142.856 157.408 148.614 1.00 33.66  ? 325 ILE B C   1 
ATOM   3969 O O   . ILE B 1 325 ? 143.207 157.338 149.797 1.00 32.44  ? 325 ILE B O   1 
ATOM   3970 C CB  . ILE B 1 325 ? 144.316 156.550 146.739 1.00 28.10  ? 325 ILE B CB  1 
ATOM   3971 C CG1 . ILE B 1 325 ? 144.766 155.276 146.031 1.00 30.47  ? 325 ILE B CG1 1 
ATOM   3972 C CG2 . ILE B 1 325 ? 145.462 157.156 147.532 1.00 26.18  ? 325 ILE B CG2 1 
ATOM   3973 C CD1 . ILE B 1 325 ? 145.858 155.515 145.042 1.00 36.56  ? 325 ILE B CD1 1 
ATOM   3974 N N   . LEU B 1 326 ? 142.233 158.482 148.123 1.00 30.83  ? 326 LEU B N   1 
ATOM   3975 C CA  . LEU B 1 326 ? 141.908 159.606 149.001 1.00 28.48  ? 326 LEU B CA  1 
ATOM   3976 C C   . LEU B 1 326 ? 140.926 159.196 150.094 1.00 29.26  ? 326 LEU B C   1 
ATOM   3977 O O   . LEU B 1 326 ? 141.071 159.597 151.255 1.00 32.56  ? 326 LEU B O   1 
ATOM   3978 C CB  . LEU B 1 326 ? 141.343 160.765 148.186 1.00 30.81  ? 326 LEU B CB  1 
ATOM   3979 C CG  . LEU B 1 326 ? 142.310 161.415 147.199 1.00 36.54  ? 326 LEU B CG  1 
ATOM   3980 C CD1 . LEU B 1 326 ? 141.619 162.537 146.459 1.00 45.83  ? 326 LEU B CD1 1 
ATOM   3981 C CD2 . LEU B 1 326 ? 143.539 161.927 147.922 1.00 34.36  ? 326 LEU B CD2 1 
ATOM   3982 N N   . TRP B 1 327 ? 139.920 158.397 149.737 1.00 30.02  ? 327 TRP B N   1 
ATOM   3983 C CA  . TRP B 1 327 ? 138.931 157.930 150.703 1.00 30.45  ? 327 TRP B CA  1 
ATOM   3984 C C   . TRP B 1 327 ? 139.580 157.076 151.787 1.00 30.35  ? 327 TRP B C   1 
ATOM   3985 O O   . TRP B 1 327 ? 139.300 157.244 152.981 1.00 30.95  ? 327 TRP B O   1 
ATOM   3986 C CB  . TRP B 1 327 ? 137.845 157.153 149.956 1.00 28.25  ? 327 TRP B CB  1 
ATOM   3987 C CG  . TRP B 1 327 ? 136.713 156.646 150.787 1.00 30.99  ? 327 TRP B CG  1 
ATOM   3988 C CD1 . TRP B 1 327 ? 135.589 157.327 151.139 1.00 25.43  ? 327 TRP B CD1 1 
ATOM   3989 C CD2 . TRP B 1 327 ? 136.579 155.335 151.342 1.00 32.78  ? 327 TRP B CD2 1 
ATOM   3990 N NE1 . TRP B 1 327 ? 134.770 156.528 151.896 1.00 25.38  ? 327 TRP B NE1 1 
ATOM   3991 C CE2 . TRP B 1 327 ? 135.356 155.298 152.034 1.00 29.88  ? 327 TRP B CE2 1 
ATOM   3992 C CE3 . TRP B 1 327 ? 137.380 154.190 151.329 1.00 28.65  ? 327 TRP B CE3 1 
ATOM   3993 C CZ2 . TRP B 1 327 ? 134.915 154.164 152.707 1.00 27.64  ? 327 TRP B CZ2 1 
ATOM   3994 C CZ3 . TRP B 1 327 ? 136.941 153.067 151.996 1.00 27.70  ? 327 TRP B CZ3 1 
ATOM   3995 C CH2 . TRP B 1 327 ? 135.720 153.061 152.676 1.00 27.60  ? 327 TRP B CH2 1 
ATOM   3996 N N   . CYS B 1 328 ? 140.467 156.161 151.387 1.00 28.01  ? 328 CYS B N   1 
ATOM   3997 C CA  . CYS B 1 328 ? 141.177 155.330 152.352 1.00 27.68  ? 328 CYS B CA  1 
ATOM   3998 C C   . CYS B 1 328 ? 142.101 156.162 153.228 1.00 34.21  ? 328 CYS B C   1 
ATOM   3999 O O   . CYS B 1 328 ? 142.224 155.900 154.427 1.00 37.46  ? 328 CYS B O   1 
ATOM   4000 C CB  . CYS B 1 328 ? 141.970 154.243 151.631 1.00 30.60  ? 328 CYS B CB  1 
ATOM   4001 S SG  . CYS B 1 328 ? 140.967 152.984 150.833 1.00 57.27  ? 328 CYS B SG  1 
ATOM   4002 N N   . LEU B 1 329 ? 142.772 157.160 152.649 1.00 33.22  ? 329 LEU B N   1 
ATOM   4003 C CA  . LEU B 1 329 ? 143.650 158.008 153.448 1.00 31.28  ? 329 LEU B CA  1 
ATOM   4004 C C   . LEU B 1 329 ? 142.864 158.790 154.490 1.00 32.81  ? 329 LEU B C   1 
ATOM   4005 O O   . LEU B 1 329 ? 143.285 158.891 155.647 1.00 41.13  ? 329 LEU B O   1 
ATOM   4006 C CB  . LEU B 1 329 ? 144.439 158.955 152.544 1.00 29.91  ? 329 LEU B CB  1 
ATOM   4007 C CG  . LEU B 1 329 ? 145.580 158.335 151.736 1.00 24.19  ? 329 LEU B CG  1 
ATOM   4008 C CD1 . LEU B 1 329 ? 146.299 159.399 150.927 1.00 23.83  ? 329 LEU B CD1 1 
ATOM   4009 C CD2 . LEU B 1 329 ? 146.552 157.598 152.643 1.00 18.90  ? 329 LEU B CD2 1 
ATOM   4010 N N   . SER B 1 330 ? 141.711 159.343 154.104 1.00 30.89  ? 330 SER B N   1 
ATOM   4011 C CA  . SER B 1 330 ? 140.896 160.080 155.066 1.00 38.68  ? 330 SER B CA  1 
ATOM   4012 C C   . SER B 1 330 ? 140.330 159.159 156.142 1.00 38.96  ? 330 SER B C   1 
ATOM   4013 O O   . SER B 1 330 ? 140.287 159.526 157.323 1.00 43.99  ? 330 SER B O   1 
ATOM   4014 C CB  . SER B 1 330 ? 139.775 160.823 154.345 1.00 40.09  ? 330 SER B CB  1 
ATOM   4015 O OG  . SER B 1 330 ? 138.992 159.936 153.571 1.00 51.40  ? 330 SER B OG  1 
ATOM   4016 N N   . LEU B 1 331 ? 139.902 157.954 155.763 1.00 34.21  ? 331 LEU B N   1 
ATOM   4017 C CA  . LEU B 1 331 ? 139.375 157.026 156.757 1.00 34.39  ? 331 LEU B CA  1 
ATOM   4018 C C   . LEU B 1 331 ? 140.468 156.554 157.711 1.00 43.47  ? 331 LEU B C   1 
ATOM   4019 O O   . LEU B 1 331 ? 140.222 156.381 158.910 1.00 55.64  ? 331 LEU B O   1 
ATOM   4020 C CB  . LEU B 1 331 ? 138.700 155.847 156.057 1.00 35.58  ? 331 LEU B CB  1 
ATOM   4021 C CG  . LEU B 1 331 ? 137.772 154.972 156.898 1.00 40.75  ? 331 LEU B CG  1 
ATOM   4022 C CD1 . LEU B 1 331 ? 136.945 155.817 157.837 1.00 43.37  ? 331 LEU B CD1 1 
ATOM   4023 C CD2 . LEU B 1 331 ? 136.868 154.166 155.994 1.00 33.41  ? 331 LEU B CD2 1 
ATOM   4024 N N   . LEU B 1 332 ? 141.684 156.340 157.200 1.00 38.50  ? 332 LEU B N   1 
ATOM   4025 C CA  . LEU B 1 332 ? 142.807 155.998 158.064 1.00 37.60  ? 332 LEU B CA  1 
ATOM   4026 C C   . LEU B 1 332 ? 143.153 157.147 158.999 1.00 45.53  ? 332 LEU B C   1 
ATOM   4027 O O   . LEU B 1 332 ? 143.453 156.928 160.178 1.00 55.24  ? 332 LEU B O   1 
ATOM   4028 C CB  . LEU B 1 332 ? 144.022 155.614 157.221 1.00 35.51  ? 332 LEU B CB  1 
ATOM   4029 C CG  . LEU B 1 332 ? 144.057 154.203 156.636 1.00 39.98  ? 332 LEU B CG  1 
ATOM   4030 C CD1 . LEU B 1 332 ? 145.201 154.074 155.653 1.00 30.53  ? 332 LEU B CD1 1 
ATOM   4031 C CD2 . LEU B 1 332 ? 144.193 153.175 157.742 1.00 39.79  ? 332 LEU B CD2 1 
ATOM   4032 N N   . ALA B 1 333 ? 143.125 158.380 158.491 1.00 43.77  ? 333 ALA B N   1 
ATOM   4033 C CA  . ALA B 1 333 ? 143.370 159.535 159.345 1.00 46.60  ? 333 ALA B CA  1 
ATOM   4034 C C   . ALA B 1 333 ? 142.331 159.623 160.453 1.00 54.18  ? 333 ALA B C   1 
ATOM   4035 O O   . ALA B 1 333 ? 142.652 159.990 161.589 1.00 63.70  ? 333 ALA B O   1 
ATOM   4036 C CB  . ALA B 1 333 ? 143.380 160.812 158.508 1.00 43.46  ? 333 ALA B CB  1 
ATOM   4037 N N   . CYS B 1 334 ? 141.076 159.300 160.139 1.00 53.18  ? 334 CYS B N   1 
ATOM   4038 C CA  . CYS B 1 334 ? 140.062 159.201 161.185 1.00 56.01  ? 334 CYS B CA  1 
ATOM   4039 C C   . CYS B 1 334 ? 140.403 158.096 162.179 1.00 62.14  ? 334 CYS B C   1 
ATOM   4040 O O   . CYS B 1 334 ? 140.230 158.266 163.391 1.00 70.33  ? 334 CYS B O   1 
ATOM   4041 C CB  . CYS B 1 334 ? 138.686 158.967 160.564 1.00 45.86  ? 334 CYS B CB  1 
ATOM   4042 S SG  . CYS B 1 334 ? 138.073 160.349 159.583 1.00 67.93  ? 334 CYS B SG  1 
ATOM   4043 N N   . PHE B 1 335 ? 140.889 156.954 161.687 1.00 60.68  ? 335 PHE B N   1 
ATOM   4044 C CA  . PHE B 1 335 ? 141.299 155.874 162.582 1.00 59.74  ? 335 PHE B CA  1 
ATOM   4045 C C   . PHE B 1 335 ? 142.630 156.194 163.254 1.00 68.08  ? 335 PHE B C   1 
ATOM   4046 O O   . PHE B 1 335 ? 142.710 156.318 164.481 1.00 72.29  ? 335 PHE B O   1 
ATOM   4047 C CB  . PHE B 1 335 ? 141.396 154.557 161.811 1.00 57.76  ? 335 PHE B CB  1 
ATOM   4048 C CG  . PHE B 1 335 ? 140.068 153.980 161.416 1.00 65.13  ? 335 PHE B CG  1 
ATOM   4049 C CD1 . PHE B 1 335 ? 138.903 154.397 162.030 1.00 69.02  ? 335 PHE B CD1 1 
ATOM   4050 C CD2 . PHE B 1 335 ? 139.990 153.010 160.435 1.00 66.07  ? 335 PHE B CD2 1 
ATOM   4051 C CE1 . PHE B 1 335 ? 137.685 153.860 161.668 1.00 67.67  ? 335 PHE B CE1 1 
ATOM   4052 C CE2 . PHE B 1 335 ? 138.775 152.471 160.069 1.00 63.87  ? 335 PHE B CE2 1 
ATOM   4053 C CZ  . PHE B 1 335 ? 137.622 152.897 160.687 1.00 66.16  ? 335 PHE B CZ  1 
ATOM   4054 N N   . PHE B 1 336 ? 143.691 156.327 162.460 1.00 70.75  ? 336 PHE B N   1 
ATOM   4055 C CA  . PHE B 1 336 ? 145.013 156.702 162.962 1.00 69.47  ? 336 PHE B CA  1 
ATOM   4056 C C   . PHE B 1 336 ? 145.140 158.213 162.842 1.00 71.90  ? 336 PHE B C   1 
ATOM   4057 O O   . PHE B 1 336 ? 145.509 158.741 161.795 1.00 72.91  ? 336 PHE B O   1 
ATOM   4058 C CB  . PHE B 1 336 ? 146.115 155.999 162.181 1.00 65.69  ? 336 PHE B CB  1 
ATOM   4059 C CG  . PHE B 1 336 ? 146.194 154.524 162.428 1.00 71.36  ? 336 PHE B CG  1 
ATOM   4060 C CD1 . PHE B 1 336 ? 145.827 153.989 163.648 1.00 78.55  ? 336 PHE B CD1 1 
ATOM   4061 C CD2 . PHE B 1 336 ? 146.641 153.670 161.436 1.00 72.94  ? 336 PHE B CD2 1 
ATOM   4062 C CE1 . PHE B 1 336 ? 145.904 152.630 163.873 1.00 81.65  ? 336 PHE B CE1 1 
ATOM   4063 C CE2 . PHE B 1 336 ? 146.720 152.312 161.655 1.00 75.51  ? 336 PHE B CE2 1 
ATOM   4064 C CZ  . PHE B 1 336 ? 146.351 151.791 162.875 1.00 76.37  ? 336 PHE B CZ  1 
ATOM   4065 N N   . ALA B 1 337 ? 144.832 158.915 163.921 1.00 75.11  ? 337 ALA B N   1 
ATOM   4066 C CA  . ALA B 1 337 ? 144.937 160.368 163.926 1.00 83.25  ? 337 ALA B CA  1 
ATOM   4067 C C   . ALA B 1 337 ? 146.396 160.780 163.787 1.00 87.93  ? 337 ALA B C   1 
ATOM   4068 O O   . ALA B 1 337 ? 147.165 160.613 164.743 1.00 88.25  ? 337 ALA B O   1 
ATOM   4069 C CB  . ALA B 1 337 ? 144.338 160.940 165.208 1.00 79.05  ? 337 ALA B CB  1 
ATOM   4070 N N   . PRO B 1 338 ? 146.824 161.312 162.639 1.00 86.75  ? 338 PRO B N   1 
ATOM   4071 C CA  . PRO B 1 338 ? 148.256 161.606 162.477 1.00 94.61  ? 338 PRO B CA  1 
ATOM   4072 C C   . PRO B 1 338 ? 148.703 162.816 163.272 1.00 98.60  ? 338 PRO B C   1 
ATOM   4073 O O   . PRO B 1 338 ? 149.783 162.795 163.874 1.00 99.29  ? 338 PRO B O   1 
ATOM   4074 C CB  . PRO B 1 338 ? 148.400 161.833 160.962 1.00 90.87  ? 338 PRO B CB  1 
ATOM   4075 C CG  . PRO B 1 338 ? 147.045 161.505 160.359 1.00 81.68  ? 338 PRO B CG  1 
ATOM   4076 C CD  . PRO B 1 338 ? 146.054 161.710 161.453 1.00 77.89  ? 338 PRO B CD  1 
ATOM   4077 N N   . ILE B 1 339 ? 147.898 163.874 163.291 1.00 100.15 ? 339 ILE B N   1 
ATOM   4078 C CA  . ILE B 1 339 ? 148.242 165.127 163.950 1.00 102.65 ? 339 ILE B CA  1 
ATOM   4079 C C   . ILE B 1 339 ? 147.246 165.345 165.078 1.00 107.38 ? 339 ILE B C   1 
ATOM   4080 O O   . ILE B 1 339 ? 146.030 165.350 164.848 1.00 105.75 ? 339 ILE B O   1 
ATOM   4081 C CB  . ILE B 1 339 ? 148.231 166.307 162.967 1.00 99.23  ? 339 ILE B CB  1 
ATOM   4082 C CG1 . ILE B 1 339 ? 148.916 165.925 161.653 1.00 92.78  ? 339 ILE B CG1 1 
ATOM   4083 C CG2 . ILE B 1 339 ? 148.925 167.507 163.578 1.00 101.36 ? 339 ILE B CG2 1 
ATOM   4084 C CD1 . ILE B 1 339 ? 147.959 165.535 160.547 1.00 92.17  ? 339 ILE B CD1 1 
ATOM   4085 N N   . SER B 1 340 ? 147.758 165.525 166.297 1.00 111.10 ? 340 SER B N   1 
ATOM   4086 C CA  . SER B 1 340 ? 146.887 165.724 167.448 1.00 113.80 ? 340 SER B CA  1 
ATOM   4087 C C   . SER B 1 340 ? 146.198 167.082 167.429 1.00 111.11 ? 340 SER B C   1 
ATOM   4088 O O   . SER B 1 340 ? 145.165 167.246 168.087 1.00 107.43 ? 340 SER B O   1 
ATOM   4089 C CB  . SER B 1 340 ? 147.680 165.564 168.745 1.00 114.95 ? 340 SER B CB  1 
ATOM   4090 O OG  . SER B 1 340 ? 148.679 166.563 168.860 1.00 119.82 ? 340 SER B OG  1 
ATOM   4091 N N   . VAL B 1 341 ? 146.740 168.056 166.695 1.00 108.68 ? 341 VAL B N   1 
ATOM   4092 C CA  . VAL B 1 341 ? 146.122 169.376 166.649 1.00 110.29 ? 341 VAL B CA  1 
ATOM   4093 C C   . VAL B 1 341 ? 145.015 169.458 165.608 1.00 107.92 ? 341 VAL B C   1 
ATOM   4094 O O   . VAL B 1 341 ? 144.233 170.416 165.623 1.00 108.99 ? 341 VAL B O   1 
ATOM   4095 C CB  . VAL B 1 341 ? 147.169 170.469 166.376 1.00 112.53 ? 341 VAL B CB  1 
ATOM   4096 C CG1 . VAL B 1 341 ? 148.422 170.228 167.206 1.00 110.39 ? 341 VAL B CG1 1 
ATOM   4097 C CG2 . VAL B 1 341 ? 147.500 170.541 164.893 1.00 105.10 ? 341 VAL B CG2 1 
ATOM   4098 N N   . ILE B 1 342 ? 144.926 168.489 164.707 1.00 106.42 ? 342 ILE B N   1 
ATOM   4099 C CA  . ILE B 1 342 ? 143.905 168.464 163.663 1.00 103.75 ? 342 ILE B CA  1 
ATOM   4100 C C   . ILE B 1 342 ? 142.768 167.566 164.140 1.00 102.97 ? 342 ILE B C   1 
ATOM   4101 O O   . ILE B 1 342 ? 142.994 166.366 164.355 1.00 103.93 ? 342 ILE B O   1 
ATOM   4102 C CB  . ILE B 1 342 ? 144.474 167.971 162.326 1.00 96.89  ? 342 ILE B CB  1 
ATOM   4103 C CG1 . ILE B 1 342 ? 145.535 168.943 161.811 1.00 94.06  ? 342 ILE B CG1 1 
ATOM   4104 C CG2 . ILE B 1 342 ? 143.368 167.816 161.304 1.00 88.23  ? 342 ILE B CG2 1 
ATOM   4105 C CD1 . ILE B 1 342 ? 145.010 170.338 161.565 1.00 92.67  ? 342 ILE B CD1 1 
ATOM   4106 N N   . PRO B 1 343 ? 141.560 168.090 164.325 1.00 100.44 ? 343 PRO B N   1 
ATOM   4107 C CA  . PRO B 1 343 ? 140.458 167.251 164.802 1.00 98.78  ? 343 PRO B CA  1 
ATOM   4108 C C   . PRO B 1 343 ? 140.001 166.266 163.739 1.00 97.01  ? 343 PRO B C   1 
ATOM   4109 O O   . PRO B 1 343 ? 140.131 166.506 162.537 1.00 96.94  ? 343 PRO B O   1 
ATOM   4110 C CB  . PRO B 1 343 ? 139.360 168.267 165.125 1.00 101.48 ? 343 PRO B CB  1 
ATOM   4111 C CG  . PRO B 1 343 ? 139.637 169.402 164.201 1.00 96.27  ? 343 PRO B CG  1 
ATOM   4112 C CD  . PRO B 1 343 ? 141.133 169.477 164.073 1.00 98.47  ? 343 PRO B CD  1 
ATOM   4113 N N   . THR B 1 344 ? 139.449 165.147 164.199 1.00 98.81  ? 344 THR B N   1 
ATOM   4114 C CA  . THR B 1 344 ? 138.969 164.102 163.296 1.00 95.07  ? 344 THR B CA  1 
ATOM   4115 C C   . THR B 1 344 ? 137.528 164.349 162.863 1.00 94.11  ? 344 THR B C   1 
ATOM   4116 O O   . THR B 1 344 ? 136.670 163.473 162.954 1.00 100.87 ? 344 THR B O   1 
ATOM   4117 C CB  . THR B 1 344 ? 139.110 162.733 163.950 1.00 93.30  ? 344 THR B CB  1 
ATOM   4118 O OG1 . THR B 1 344 ? 138.397 162.718 165.192 1.00 102.56 ? 344 THR B OG1 1 
ATOM   4119 C CG2 . THR B 1 344 ? 140.572 162.414 164.202 1.00 91.18  ? 344 THR B CG2 1 
ATOM   4120 N N   . TYR B 1 345 ? 137.255 165.561 162.388 1.00 89.77  ? 345 TYR B N   1 
ATOM   4121 C CA  . TYR B 1 345 ? 136.026 165.832 161.659 1.00 86.80  ? 345 TYR B CA  1 
ATOM   4122 C C   . TYR B 1 345 ? 136.267 166.673 160.417 1.00 84.91  ? 345 TYR B C   1 
ATOM   4123 O O   . TYR B 1 345 ? 135.310 166.959 159.692 1.00 86.36  ? 345 TYR B O   1 
ATOM   4124 C CB  . TYR B 1 345 ? 134.978 166.514 162.559 1.00 91.44  ? 345 TYR B CB  1 
ATOM   4125 C CG  . TYR B 1 345 ? 135.434 167.771 163.269 1.00 95.35  ? 345 TYR B CG  1 
ATOM   4126 C CD1 . TYR B 1 345 ? 135.662 168.949 162.569 1.00 95.38  ? 345 TYR B CD1 1 
ATOM   4127 C CD2 . TYR B 1 345 ? 135.598 167.789 164.648 1.00 96.62  ? 345 TYR B CD2 1 
ATOM   4128 C CE1 . TYR B 1 345 ? 136.067 170.097 163.216 1.00 98.70  ? 345 TYR B CE1 1 
ATOM   4129 C CE2 . TYR B 1 345 ? 135.998 168.934 165.304 1.00 101.89 ? 345 TYR B CE2 1 
ATOM   4130 C CZ  . TYR B 1 345 ? 136.232 170.085 164.583 1.00 103.44 ? 345 TYR B CZ  1 
ATOM   4131 O OH  . TYR B 1 345 ? 136.634 171.230 165.230 1.00 102.34 ? 345 TYR B OH  1 
ATOM   4132 N N   . VAL B 1 346 ? 137.508 167.081 160.152 1.00 82.84  ? 346 VAL B N   1 
ATOM   4133 C CA  . VAL B 1 346 ? 137.832 167.777 158.915 1.00 78.41  ? 346 VAL B CA  1 
ATOM   4134 C C   . VAL B 1 346 ? 138.256 166.809 157.815 1.00 73.50  ? 346 VAL B C   1 
ATOM   4135 O O   . VAL B 1 346 ? 138.164 167.155 156.629 1.00 68.42  ? 346 VAL B O   1 
ATOM   4136 C CB  . VAL B 1 346 ? 138.928 168.830 159.166 1.00 76.02  ? 346 VAL B CB  1 
ATOM   4137 C CG1 . VAL B 1 346 ? 140.260 168.161 159.450 1.00 70.74  ? 346 VAL B CG1 1 
ATOM   4138 C CG2 . VAL B 1 346 ? 139.040 169.796 157.994 1.00 70.09  ? 346 VAL B CG2 1 
ATOM   4139 N N   . TYR B 1 347 ? 138.702 165.603 158.173 1.00 73.47  ? 347 TYR B N   1 
ATOM   4140 C CA  . TYR B 1 347 ? 139.079 164.620 157.159 1.00 64.58  ? 347 TYR B CA  1 
ATOM   4141 C C   . TYR B 1 347 ? 137.918 164.231 156.255 1.00 65.75  ? 347 TYR B C   1 
ATOM   4142 O O   . TYR B 1 347 ? 138.115 164.181 155.028 1.00 61.68  ? 347 TYR B O   1 
ATOM   4143 C CB  . TYR B 1 347 ? 139.707 163.396 157.834 1.00 54.41  ? 347 TYR B CB  1 
ATOM   4144 C CG  . TYR B 1 347 ? 141.000 163.698 158.549 1.00 59.57  ? 347 TYR B CG  1 
ATOM   4145 C CD1 . TYR B 1 347 ? 142.111 164.146 157.852 1.00 53.62  ? 347 TYR B CD1 1 
ATOM   4146 C CD2 . TYR B 1 347 ? 141.113 163.528 159.921 1.00 67.45  ? 347 TYR B CD2 1 
ATOM   4147 C CE1 . TYR B 1 347 ? 143.294 164.423 158.500 1.00 53.34  ? 347 TYR B CE1 1 
ATOM   4148 C CE2 . TYR B 1 347 ? 142.295 163.800 160.577 1.00 67.93  ? 347 TYR B CE2 1 
ATOM   4149 C CZ  . TYR B 1 347 ? 143.381 164.248 159.861 1.00 65.44  ? 347 TYR B CZ  1 
ATOM   4150 O OH  . TYR B 1 347 ? 144.562 164.522 160.510 1.00 81.22  ? 347 TYR B OH  1 
ATOM   4151 N N   . PRO B 1 348 ? 136.713 163.928 156.758 1.00 63.54  ? 348 PRO B N   1 
ATOM   4152 C CA  . PRO B 1 348 ? 135.581 163.775 155.829 1.00 59.98  ? 348 PRO B CA  1 
ATOM   4153 C C   . PRO B 1 348 ? 135.315 165.033 155.026 1.00 63.53  ? 348 PRO B C   1 
ATOM   4154 O O   . PRO B 1 348 ? 135.069 164.963 153.812 1.00 62.85  ? 348 PRO B O   1 
ATOM   4155 C CB  . PRO B 1 348 ? 134.410 163.436 156.759 1.00 55.68  ? 348 PRO B CB  1 
ATOM   4156 C CG  . PRO B 1 348 ? 135.038 162.892 157.981 1.00 57.74  ? 348 PRO B CG  1 
ATOM   4157 C CD  . PRO B 1 348 ? 136.307 163.654 158.147 1.00 62.15  ? 348 PRO B CD  1 
ATOM   4158 N N   . LEU B 1 349 ? 135.374 166.193 155.684 1.00 64.36  ? 349 LEU B N   1 
ATOM   4159 C CA  . LEU B 1 349 ? 135.186 167.456 154.983 1.00 65.59  ? 349 LEU B CA  1 
ATOM   4160 C C   . LEU B 1 349 ? 136.279 167.677 153.950 1.00 58.92  ? 349 LEU B C   1 
ATOM   4161 O O   . LEU B 1 349 ? 136.003 168.136 152.840 1.00 55.77  ? 349 LEU B O   1 
ATOM   4162 C CB  . LEU B 1 349 ? 135.147 168.613 155.980 1.00 70.52  ? 349 LEU B CB  1 
ATOM   4163 C CG  . LEU B 1 349 ? 133.863 168.771 156.792 1.00 73.04  ? 349 LEU B CG  1 
ATOM   4164 C CD1 . LEU B 1 349 ? 134.005 169.902 157.793 1.00 75.07  ? 349 LEU B CD1 1 
ATOM   4165 C CD2 . LEU B 1 349 ? 132.685 169.019 155.869 1.00 70.92  ? 349 LEU B CD2 1 
ATOM   4166 N N   . ALA B 1 350 ? 137.527 167.351 154.295 1.00 58.96  ? 350 ALA B N   1 
ATOM   4167 C CA  . ALA B 1 350 ? 138.615 167.492 153.333 1.00 56.84  ? 350 ALA B CA  1 
ATOM   4168 C C   . ALA B 1 350 ? 138.414 166.579 152.131 1.00 60.19  ? 350 ALA B C   1 
ATOM   4169 O O   . ALA B 1 350 ? 138.608 167.000 150.986 1.00 60.79  ? 350 ALA B O   1 
ATOM   4170 C CB  . ALA B 1 350 ? 139.956 167.203 154.007 1.00 55.45  ? 350 ALA B CB  1 
ATOM   4171 N N   . LEU B 1 351 ? 138.009 165.330 152.371 1.00 58.06  ? 351 LEU B N   1 
ATOM   4172 C CA  . LEU B 1 351 ? 137.794 164.392 151.274 1.00 52.06  ? 351 LEU B CA  1 
ATOM   4173 C C   . LEU B 1 351 ? 136.691 164.874 150.342 1.00 55.00  ? 351 LEU B C   1 
ATOM   4174 O O   . LEU B 1 351 ? 136.858 164.894 149.116 1.00 61.27  ? 351 LEU B O   1 
ATOM   4175 C CB  . LEU B 1 351 ? 137.455 163.010 151.832 1.00 49.52  ? 351 LEU B CB  1 
ATOM   4176 C CG  . LEU B 1 351 ? 136.960 161.976 150.821 1.00 48.31  ? 351 LEU B CG  1 
ATOM   4177 C CD1 . LEU B 1 351 ? 138.041 161.659 149.807 1.00 49.28  ? 351 LEU B CD1 1 
ATOM   4178 C CD2 . LEU B 1 351 ? 136.495 160.717 151.526 1.00 41.83  ? 351 LEU B CD2 1 
ATOM   4179 N N   . TYR B 1 352 ? 135.554 165.283 150.907 1.00 55.39  ? 352 TYR B N   1 
ATOM   4180 C CA  . TYR B 1 352 ? 134.439 165.692 150.061 1.00 51.12  ? 352 TYR B CA  1 
ATOM   4181 C C   . TYR B 1 352 ? 134.701 167.034 149.391 1.00 58.64  ? 352 TYR B C   1 
ATOM   4182 O O   . TYR B 1 352 ? 134.280 167.244 148.247 1.00 66.88  ? 352 TYR B O   1 
ATOM   4183 C CB  . TYR B 1 352 ? 133.151 165.712 150.877 1.00 48.05  ? 352 TYR B CB  1 
ATOM   4184 C CG  . TYR B 1 352 ? 132.753 164.328 151.327 1.00 56.21  ? 352 TYR B CG  1 
ATOM   4185 C CD1 . TYR B 1 352 ? 132.789 163.260 150.442 1.00 61.19  ? 352 TYR B CD1 1 
ATOM   4186 C CD2 . TYR B 1 352 ? 132.376 164.079 152.636 1.00 58.13  ? 352 TYR B CD2 1 
ATOM   4187 C CE1 . TYR B 1 352 ? 132.444 161.987 150.842 1.00 60.41  ? 352 TYR B CE1 1 
ATOM   4188 C CE2 . TYR B 1 352 ? 132.028 162.809 153.047 1.00 59.87  ? 352 TYR B CE2 1 
ATOM   4189 C CZ  . TYR B 1 352 ? 132.064 161.767 152.146 1.00 62.26  ? 352 TYR B CZ  1 
ATOM   4190 O OH  . TYR B 1 352 ? 131.717 160.500 152.548 1.00 53.49  ? 352 TYR B OH  1 
ATOM   4191 N N   . GLY B 1 353 ? 135.414 167.941 150.060 1.00 52.59  ? 353 GLY B N   1 
ATOM   4192 C CA  . GLY B 1 353 ? 135.808 169.177 149.413 1.00 51.97  ? 353 GLY B CA  1 
ATOM   4193 C C   . GLY B 1 353 ? 136.767 168.944 148.265 1.00 61.82  ? 353 GLY B C   1 
ATOM   4194 O O   . GLY B 1 353 ? 136.675 169.602 147.228 1.00 67.03  ? 353 GLY B O   1 
ATOM   4195 N N   . PHE B 1 354 ? 137.699 168.002 148.430 1.00 63.64  ? 354 PHE B N   1 
ATOM   4196 C CA  . PHE B 1 354 ? 138.592 167.664 147.329 1.00 61.38  ? 354 PHE B CA  1 
ATOM   4197 C C   . PHE B 1 354 ? 137.821 167.048 146.172 1.00 60.37  ? 354 PHE B C   1 
ATOM   4198 O O   . PHE B 1 354 ? 138.108 167.336 145.007 1.00 60.47  ? 354 PHE B O   1 
ATOM   4199 C CB  . PHE B 1 354 ? 139.696 166.719 147.799 1.00 60.64  ? 354 PHE B CB  1 
ATOM   4200 C CG  . PHE B 1 354 ? 140.859 166.634 146.850 1.00 70.18  ? 354 PHE B CG  1 
ATOM   4201 C CD1 . PHE B 1 354 ? 140.789 165.849 145.710 1.00 65.83  ? 354 PHE B CD1 1 
ATOM   4202 C CD2 . PHE B 1 354 ? 142.020 167.348 147.093 1.00 76.12  ? 354 PHE B CD2 1 
ATOM   4203 C CE1 . PHE B 1 354 ? 141.851 165.777 144.835 1.00 66.80  ? 354 PHE B CE1 1 
ATOM   4204 C CE2 . PHE B 1 354 ? 143.087 167.276 146.220 1.00 81.00  ? 354 PHE B CE2 1 
ATOM   4205 C CZ  . PHE B 1 354 ? 143.002 166.489 145.090 1.00 76.80  ? 354 PHE B CZ  1 
ATOM   4206 N N   . MET B 1 355 ? 136.843 166.189 146.471 1.00 59.79  ? 355 MET B N   1 
ATOM   4207 C CA  . MET B 1 355 ? 136.016 165.625 145.407 1.00 58.27  ? 355 MET B CA  1 
ATOM   4208 C C   . MET B 1 355 ? 135.275 166.723 144.652 1.00 65.45  ? 355 MET B C   1 
ATOM   4209 O O   . MET B 1 355 ? 135.243 166.735 143.414 1.00 69.58  ? 355 MET B O   1 
ATOM   4210 C CB  . MET B 1 355 ? 135.031 164.611 145.985 1.00 53.09  ? 355 MET B CB  1 
ATOM   4211 C CG  . MET B 1 355 ? 135.670 163.326 146.470 1.00 57.33  ? 355 MET B CG  1 
ATOM   4212 S SD  . MET B 1 355 ? 134.447 162.113 147.000 1.00 86.85  ? 355 MET B SD  1 
ATOM   4213 C CE  . MET B 1 355 ? 135.488 160.687 147.292 1.00 59.25  ? 355 MET B CE  1 
ATOM   4214 N N   . VAL B 1 356 ? 134.688 167.671 145.388 1.00 59.65  ? 356 VAL B N   1 
ATOM   4215 C CA  . VAL B 1 356 ? 133.955 168.761 144.751 1.00 60.24  ? 356 VAL B CA  1 
ATOM   4216 C C   . VAL B 1 356 ? 134.888 169.615 143.901 1.00 65.73  ? 356 VAL B C   1 
ATOM   4217 O O   . VAL B 1 356 ? 134.562 169.967 142.762 1.00 66.15  ? 356 VAL B O   1 
ATOM   4218 C CB  . VAL B 1 356 ? 133.222 169.603 145.811 1.00 59.89  ? 356 VAL B CB  1 
ATOM   4219 C CG1 . VAL B 1 356 ? 132.642 170.856 145.184 1.00 65.08  ? 356 VAL B CG1 1 
ATOM   4220 C CG2 . VAL B 1 356 ? 132.125 168.785 146.466 1.00 58.76  ? 356 VAL B CG2 1 
ATOM   4221 N N   . PHE B 1 357 ? 136.064 169.959 144.434 1.00 66.79  ? 357 PHE B N   1 
ATOM   4222 C CA  . PHE B 1 357 ? 137.001 170.798 143.691 1.00 69.51  ? 357 PHE B CA  1 
ATOM   4223 C C   . PHE B 1 357 ? 137.552 170.085 142.464 1.00 68.00  ? 357 PHE B C   1 
ATOM   4224 O O   . PHE B 1 357 ? 137.795 170.725 141.435 1.00 62.96  ? 357 PHE B O   1 
ATOM   4225 C CB  . PHE B 1 357 ? 138.142 171.246 144.603 1.00 66.83  ? 357 PHE B CB  1 
ATOM   4226 C CG  . PHE B 1 357 ? 137.722 172.228 145.657 1.00 80.57  ? 357 PHE B CG  1 
ATOM   4227 C CD1 . PHE B 1 357 ? 136.695 173.125 145.416 1.00 79.54  ? 357 PHE B CD1 1 
ATOM   4228 C CD2 . PHE B 1 357 ? 138.349 172.252 146.892 1.00 85.30  ? 357 PHE B CD2 1 
ATOM   4229 C CE1 . PHE B 1 357 ? 136.303 174.029 146.384 1.00 84.29  ? 357 PHE B CE1 1 
ATOM   4230 C CE2 . PHE B 1 357 ? 137.961 173.154 147.863 1.00 86.74  ? 357 PHE B CE2 1 
ATOM   4231 C CZ  . PHE B 1 357 ? 136.937 174.043 147.609 1.00 89.97  ? 357 PHE B CZ  1 
ATOM   4232 N N   . PHE B 1 358 ? 137.772 168.772 142.556 1.00 62.60  ? 358 PHE B N   1 
ATOM   4233 C CA  . PHE B 1 358 ? 138.160 168.002 141.382 1.00 56.66  ? 358 PHE B CA  1 
ATOM   4234 C C   . PHE B 1 358 ? 137.062 168.028 140.332 1.00 57.10  ? 358 PHE B C   1 
ATOM   4235 O O   . PHE B 1 358 ? 137.341 168.159 139.137 1.00 49.66  ? 358 PHE B O   1 
ATOM   4236 C CB  . PHE B 1 358 ? 138.493 166.564 141.785 1.00 59.41  ? 358 PHE B CB  1 
ATOM   4237 C CG  . PHE B 1 358 ? 138.750 165.646 140.620 1.00 61.21  ? 358 PHE B CG  1 
ATOM   4238 C CD1 . PHE B 1 358 ? 139.984 165.625 139.995 1.00 61.31  ? 358 PHE B CD1 1 
ATOM   4239 C CD2 . PHE B 1 358 ? 137.759 164.796 140.157 1.00 55.98  ? 358 PHE B CD2 1 
ATOM   4240 C CE1 . PHE B 1 358 ? 140.221 164.781 138.926 1.00 57.16  ? 358 PHE B CE1 1 
ATOM   4241 C CE2 . PHE B 1 358 ? 137.991 163.953 139.090 1.00 54.40  ? 358 PHE B CE2 1 
ATOM   4242 C CZ  . PHE B 1 358 ? 139.223 163.945 138.474 1.00 54.13  ? 358 PHE B CZ  1 
ATOM   4243 N N   . LEU B 1 359 ? 135.803 167.910 140.760 1.00 61.09  ? 359 LEU B N   1 
ATOM   4244 C CA  . LEU B 1 359 ? 134.700 167.915 139.805 1.00 60.72  ? 359 LEU B CA  1 
ATOM   4245 C C   . LEU B 1 359 ? 134.550 169.273 139.126 1.00 60.53  ? 359 LEU B C   1 
ATOM   4246 O O   . LEU B 1 359 ? 134.376 169.349 137.904 1.00 58.25  ? 359 LEU B O   1 
ATOM   4247 C CB  . LEU B 1 359 ? 133.402 167.512 140.504 1.00 54.76  ? 359 LEU B CB  1 
ATOM   4248 C CG  . LEU B 1 359 ? 132.153 167.498 139.625 1.00 55.08  ? 359 LEU B CG  1 
ATOM   4249 C CD1 . LEU B 1 359 ? 132.357 166.603 138.415 1.00 49.82  ? 359 LEU B CD1 1 
ATOM   4250 C CD2 . LEU B 1 359 ? 130.948 167.051 140.429 1.00 56.07  ? 359 LEU B CD2 1 
ATOM   4251 N N   . ILE B 1 360 ? 134.623 170.357 139.894 1.00 61.30  ? 360 ILE B N   1 
ATOM   4252 C CA  . ILE B 1 360 ? 134.330 171.691 139.380 1.00 59.29  ? 360 ILE B CA  1 
ATOM   4253 C C   . ILE B 1 360 ? 135.608 172.482 139.091 1.00 65.20  ? 360 ILE B C   1 
ATOM   4254 O O   . ILE B 1 360 ? 135.581 173.711 139.073 1.00 64.93  ? 360 ILE B O   1 
ATOM   4255 C CB  . ILE B 1 360 ? 133.400 172.470 140.323 1.00 58.26  ? 360 ILE B CB  1 
ATOM   4256 C CG1 . ILE B 1 360 ? 134.111 172.810 141.633 1.00 60.85  ? 360 ILE B CG1 1 
ATOM   4257 C CG2 . ILE B 1 360 ? 132.135 171.677 140.598 1.00 54.46  ? 360 ILE B CG2 1 
ATOM   4258 C CD1 . ILE B 1 360 ? 133.246 173.557 142.617 1.00 66.05  ? 360 ILE B CD1 1 
ATOM   4259 N N   . ASN B 1 361 ? 136.721 171.798 138.857 1.00 69.74  ? 361 ASN B N   1 
ATOM   4260 C CA  . ASN B 1 361 ? 137.977 172.466 138.540 1.00 60.74  ? 361 ASN B CA  1 
ATOM   4261 C C   . ASN B 1 361 ? 137.820 173.275 137.257 1.00 65.05  ? 361 ASN B C   1 
ATOM   4262 O O   . ASN B 1 361 ? 137.490 172.701 136.208 1.00 62.40  ? 361 ASN B O   1 
ATOM   4263 C CB  . ASN B 1 361 ? 139.090 171.431 138.386 1.00 60.23  ? 361 ASN B CB  1 
ATOM   4264 C CG  . ASN B 1 361 ? 140.467 172.054 138.260 1.00 66.04  ? 361 ASN B CG  1 
ATOM   4265 O OD1 . ASN B 1 361 ? 140.608 173.251 138.019 1.00 72.14  ? 361 ASN B OD1 1 
ATOM   4266 N ND2 . ASN B 1 361 ? 141.497 171.232 138.415 1.00 74.50  ? 361 ASN B ND2 1 
ATOM   4267 N N   . PRO B 1 362 ? 138.044 174.594 137.287 1.00 65.54  ? 362 PRO B N   1 
ATOM   4268 C CA  . PRO B 1 362 ? 137.895 175.390 136.061 1.00 61.70  ? 362 PRO B CA  1 
ATOM   4269 C C   . PRO B 1 362 ? 139.069 175.281 135.106 1.00 60.84  ? 362 PRO B C   1 
ATOM   4270 O O   . PRO B 1 362 ? 138.895 175.556 133.911 1.00 60.55  ? 362 PRO B O   1 
ATOM   4271 C CB  . PRO B 1 362 ? 137.753 176.821 136.592 1.00 57.54  ? 362 PRO B CB  1 
ATOM   4272 C CG  . PRO B 1 362 ? 138.496 176.803 137.879 1.00 59.17  ? 362 PRO B CG  1 
ATOM   4273 C CD  . PRO B 1 362 ? 138.287 175.438 138.469 1.00 55.83  ? 362 PRO B CD  1 
ATOM   4274 N N   . THR B 1 363 ? 140.247 174.891 135.585 1.00 60.91  ? 363 THR B N   1 
ATOM   4275 C CA  . THR B 1 363 ? 141.407 174.756 134.720 1.00 58.12  ? 363 THR B CA  1 
ATOM   4276 C C   . THR B 1 363 ? 141.244 173.560 133.785 1.00 61.80  ? 363 THR B C   1 
ATOM   4277 O O   . THR B 1 363 ? 140.514 172.608 134.069 1.00 68.21  ? 363 THR B O   1 
ATOM   4278 C CB  . THR B 1 363 ? 142.679 174.602 135.552 1.00 57.55  ? 363 THR B CB  1 
ATOM   4279 O OG1 . THR B 1 363 ? 142.525 173.507 136.463 1.00 69.40  ? 363 THR B OG1 1 
ATOM   4280 C CG2 . THR B 1 363 ? 142.951 175.868 136.343 1.00 57.60  ? 363 THR B CG2 1 
ATOM   4281 N N   . LYS B 1 364 ? 141.936 173.620 132.653 1.00 57.64  ? 364 LYS B N   1 
ATOM   4282 C CA  . LYS B 1 364 ? 141.855 172.562 131.647 1.00 61.36  ? 364 LYS B CA  1 
ATOM   4283 C C   . LYS B 1 364 ? 142.840 171.433 131.935 1.00 64.72  ? 364 LYS B C   1 
ATOM   4284 O O   . LYS B 1 364 ? 143.673 171.076 131.105 1.00 63.34  ? 364 LYS B O   1 
ATOM   4285 C CB  . LYS B 1 364 ? 142.080 173.144 130.258 1.00 65.85  ? 364 LYS B CB  1 
ATOM   4286 C CG  . LYS B 1 364 ? 140.986 174.092 129.805 1.00 69.33  ? 364 LYS B CG  1 
ATOM   4287 C CD  . LYS B 1 364 ? 141.131 174.437 128.334 1.00 69.47  ? 364 LYS B CD  1 
ATOM   4288 C CE  . LYS B 1 364 ? 140.100 175.466 127.909 1.00 68.14  ? 364 LYS B CE  1 
ATOM   4289 N NZ  . LYS B 1 364 ? 138.713 175.004 128.171 1.00 67.54  ? 364 LYS B NZ  1 
ATOM   4290 N N   . THR B 1 365 ? 142.741 170.859 133.132 1.00 64.89  ? 365 THR B N   1 
ATOM   4291 C CA  . THR B 1 365 ? 143.586 169.748 133.539 1.00 59.43  ? 365 THR B CA  1 
ATOM   4292 C C   . THR B 1 365 ? 142.734 168.699 134.239 1.00 63.01  ? 365 THR B C   1 
ATOM   4293 O O   . THR B 1 365 ? 141.655 168.993 134.757 1.00 66.16  ? 365 THR B O   1 
ATOM   4294 C CB  . THR B 1 365 ? 144.719 170.200 134.471 1.00 61.52  ? 365 THR B CB  1 
ATOM   4295 O OG1 . THR B 1 365 ? 144.165 170.883 135.602 1.00 60.68  ? 365 THR B OG1 1 
ATOM   4296 C CG2 . THR B 1 365 ? 145.676 171.128 133.746 1.00 68.17  ? 365 THR B CG2 1 
ATOM   4297 N N   . PHE B 1 366 ? 143.241 167.464 134.246 1.00 62.76  ? 366 PHE B N   1 
ATOM   4298 C CA  . PHE B 1 366 ? 142.636 166.340 134.963 1.00 54.53  ? 366 PHE B CA  1 
ATOM   4299 C C   . PHE B 1 366 ? 141.214 166.063 134.464 1.00 55.98  ? 366 PHE B C   1 
ATOM   4300 O O   . PHE B 1 366 ? 140.223 166.241 135.172 1.00 58.00  ? 366 PHE B O   1 
ATOM   4301 C CB  . PHE B 1 366 ? 142.656 166.589 136.475 1.00 52.20  ? 366 PHE B CB  1 
ATOM   4302 C CG  . PHE B 1 366 ? 144.016 166.922 137.010 1.00 63.80  ? 366 PHE B CG  1 
ATOM   4303 C CD1 . PHE B 1 366 ? 145.007 165.959 137.066 1.00 65.74  ? 366 PHE B CD1 1 
ATOM   4304 C CD2 . PHE B 1 366 ? 144.305 168.199 137.457 1.00 67.21  ? 366 PHE B CD2 1 
ATOM   4305 C CE1 . PHE B 1 366 ? 146.261 166.262 137.556 1.00 64.11  ? 366 PHE B CE1 1 
ATOM   4306 C CE2 . PHE B 1 366 ? 145.557 168.508 137.949 1.00 70.71  ? 366 PHE B CE2 1 
ATOM   4307 C CZ  . PHE B 1 366 ? 146.536 167.537 137.999 1.00 71.40  ? 366 PHE B CZ  1 
ATOM   4308 N N   . TYR B 1 367 ? 141.153 165.632 133.203 1.00 54.03  ? 367 TYR B N   1 
ATOM   4309 C CA  . TYR B 1 367 ? 139.905 165.218 132.559 1.00 46.89  ? 367 TYR B CA  1 
ATOM   4310 C C   . TYR B 1 367 ? 138.926 166.385 132.449 1.00 52.05  ? 367 TYR B C   1 
ATOM   4311 O O   . TYR B 1 367 ? 137.746 166.263 132.775 1.00 56.21  ? 367 TYR B O   1 
ATOM   4312 C CB  . TYR B 1 367 ? 139.255 164.045 133.301 1.00 47.72  ? 367 TYR B CB  1 
ATOM   4313 C CG  . TYR B 1 367 ? 140.154 162.857 133.547 1.00 50.49  ? 367 TYR B CG  1 
ATOM   4314 C CD1 . TYR B 1 367 ? 140.479 161.983 132.521 1.00 47.84  ? 367 TYR B CD1 1 
ATOM   4315 C CD2 . TYR B 1 367 ? 140.654 162.595 134.814 1.00 42.58  ? 367 TYR B CD2 1 
ATOM   4316 C CE1 . TYR B 1 367 ? 141.292 160.894 132.746 1.00 40.65  ? 367 TYR B CE1 1 
ATOM   4317 C CE2 . TYR B 1 367 ? 141.465 161.508 135.047 1.00 37.45  ? 367 TYR B CE2 1 
ATOM   4318 C CZ  . TYR B 1 367 ? 141.781 160.661 134.011 1.00 43.06  ? 367 TYR B CZ  1 
ATOM   4319 O OH  . TYR B 1 367 ? 142.592 159.576 134.240 1.00 49.04  ? 367 TYR B OH  1 
ATOM   4320 N N   . TYR B 1 368 ? 139.425 167.527 131.973 1.00 55.20  ? 368 TYR B N   1 
ATOM   4321 C CA  . TYR B 1 368 ? 138.598 168.729 131.952 1.00 50.42  ? 368 TYR B CA  1 
ATOM   4322 C C   . TYR B 1 368 ? 137.389 168.564 131.038 1.00 53.64  ? 368 TYR B C   1 
ATOM   4323 O O   . TYR B 1 368 ? 136.286 169.006 131.378 1.00 56.23  ? 368 TYR B O   1 
ATOM   4324 C CB  . TYR B 1 368 ? 139.433 169.941 131.541 1.00 54.83  ? 368 TYR B CB  1 
ATOM   4325 C CG  . TYR B 1 368 ? 139.807 169.994 130.080 1.00 61.85  ? 368 TYR B CG  1 
ATOM   4326 C CD1 . TYR B 1 368 ? 140.876 169.260 129.590 1.00 64.12  ? 368 TYR B CD1 1 
ATOM   4327 C CD2 . TYR B 1 368 ? 139.100 170.792 129.194 1.00 63.72  ? 368 TYR B CD2 1 
ATOM   4328 C CE1 . TYR B 1 368 ? 141.222 169.309 128.256 1.00 69.73  ? 368 TYR B CE1 1 
ATOM   4329 C CE2 . TYR B 1 368 ? 139.438 170.848 127.859 1.00 69.56  ? 368 TYR B CE2 1 
ATOM   4330 C CZ  . TYR B 1 368 ? 140.501 170.105 127.395 1.00 74.72  ? 368 TYR B CZ  1 
ATOM   4331 O OH  . TYR B 1 368 ? 140.842 170.157 126.064 1.00 82.37  ? 368 TYR B OH  1 
ATOM   4332 N N   . LYS B 1 369 ? 137.571 167.929 129.878 1.00 52.02  ? 369 LYS B N   1 
ATOM   4333 C CA  . LYS B 1 369 ? 136.455 167.742 128.955 1.00 52.42  ? 369 LYS B CA  1 
ATOM   4334 C C   . LYS B 1 369 ? 135.341 166.925 129.595 1.00 59.42  ? 369 LYS B C   1 
ATOM   4335 O O   . LYS B 1 369 ? 134.170 167.326 129.584 1.00 64.31  ? 369 LYS B O   1 
ATOM   4336 C CB  . LYS B 1 369 ? 136.939 167.058 127.677 1.00 57.70  ? 369 LYS B CB  1 
ATOM   4337 C CG  . LYS B 1 369 ? 137.714 167.949 126.729 1.00 72.11  ? 369 LYS B CG  1 
ATOM   4338 C CD  . LYS B 1 369 ? 138.029 167.208 125.441 1.00 79.35  ? 369 LYS B CD  1 
ATOM   4339 C CE  . LYS B 1 369 ? 138.745 168.097 124.444 1.00 76.78  ? 369 LYS B CE  1 
ATOM   4340 N NZ  . LYS B 1 369 ? 139.087 167.351 123.202 1.00 89.45  ? 369 LYS B NZ  1 
ATOM   4341 N N   . SER B 1 370 ? 135.694 165.769 130.161 1.00 60.82  ? 370 SER B N   1 
ATOM   4342 C CA  . SER B 1 370 ? 134.693 164.894 130.755 1.00 49.72  ? 370 SER B CA  1 
ATOM   4343 C C   . SER B 1 370 ? 134.034 165.547 131.960 1.00 45.88  ? 370 SER B C   1 
ATOM   4344 O O   . SER B 1 370 ? 132.823 165.414 132.159 1.00 52.11  ? 370 SER B O   1 
ATOM   4345 C CB  . SER B 1 370 ? 135.332 163.565 131.148 1.00 49.53  ? 370 SER B CB  1 
ATOM   4346 O OG  . SER B 1 370 ? 136.317 163.757 132.142 1.00 52.71  ? 370 SER B OG  1 
ATOM   4347 N N   . ARG B 1 371 ? 134.814 166.253 132.780 1.00 42.44  ? 371 ARG B N   1 
ATOM   4348 C CA  . ARG B 1 371 ? 134.240 166.920 133.944 1.00 45.29  ? 371 ARG B CA  1 
ATOM   4349 C C   . ARG B 1 371 ? 133.273 168.022 133.535 1.00 50.27  ? 371 ARG B C   1 
ATOM   4350 O O   . ARG B 1 371 ? 132.216 168.187 134.151 1.00 52.34  ? 371 ARG B O   1 
ATOM   4351 C CB  . ARG B 1 371 ? 135.346 167.485 134.829 1.00 48.50  ? 371 ARG B CB  1 
ATOM   4352 C CG  . ARG B 1 371 ? 136.240 166.437 135.445 1.00 47.13  ? 371 ARG B CG  1 
ATOM   4353 C CD  . ARG B 1 371 ? 137.312 167.065 136.314 1.00 53.29  ? 371 ARG B CD  1 
ATOM   4354 N NE  . ARG B 1 371 ? 138.170 167.999 135.595 1.00 56.28  ? 371 ARG B NE  1 
ATOM   4355 C CZ  . ARG B 1 371 ? 138.030 169.318 135.615 1.00 57.33  ? 371 ARG B CZ  1 
ATOM   4356 N NH1 . ARG B 1 371 ? 137.053 169.898 136.291 1.00 61.24  ? 371 ARG B NH1 1 
ATOM   4357 N NH2 . ARG B 1 371 ? 138.889 170.073 134.937 1.00 53.86  ? 371 ARG B NH2 1 
ATOM   4358 N N   . PHE B 1 372 ? 133.621 168.798 132.505 1.00 48.99  ? 372 PHE B N   1 
ATOM   4359 C CA  . PHE B 1 372 ? 132.715 169.841 132.034 1.00 45.29  ? 372 PHE B CA  1 
ATOM   4360 C C   . PHE B 1 372 ? 131.438 169.240 131.462 1.00 45.68  ? 372 PHE B C   1 
ATOM   4361 O O   . PHE B 1 372 ? 130.338 169.757 131.702 1.00 50.65  ? 372 PHE B O   1 
ATOM   4362 C CB  . PHE B 1 372 ? 133.410 170.716 130.992 1.00 47.53  ? 372 PHE B CB  1 
ATOM   4363 C CG  . PHE B 1 372 ? 134.586 171.485 131.528 1.00 52.38  ? 372 PHE B CG  1 
ATOM   4364 C CD1 . PHE B 1 372 ? 134.769 171.644 132.892 1.00 50.63  ? 372 PHE B CD1 1 
ATOM   4365 C CD2 . PHE B 1 372 ? 135.508 172.051 130.665 1.00 52.79  ? 372 PHE B CD2 1 
ATOM   4366 C CE1 . PHE B 1 372 ? 135.849 172.346 133.383 1.00 54.47  ? 372 PHE B CE1 1 
ATOM   4367 C CE2 . PHE B 1 372 ? 136.589 172.757 131.151 1.00 57.47  ? 372 PHE B CE2 1 
ATOM   4368 C CZ  . PHE B 1 372 ? 136.760 172.904 132.511 1.00 60.42  ? 372 PHE B CZ  1 
ATOM   4369 N N   . TRP B 1 373 ? 131.564 168.147 130.707 1.00 49.12  ? 373 TRP B N   1 
ATOM   4370 C CA  . TRP B 1 373 ? 130.382 167.460 130.197 1.00 48.88  ? 373 TRP B CA  1 
ATOM   4371 C C   . TRP B 1 373 ? 129.503 166.960 131.337 1.00 42.95  ? 373 TRP B C   1 
ATOM   4372 O O   . TRP B 1 373 ? 128.275 167.096 131.292 1.00 43.87  ? 373 TRP B O   1 
ATOM   4373 C CB  . TRP B 1 373 ? 130.809 166.305 129.293 1.00 52.89  ? 373 TRP B CB  1 
ATOM   4374 C CG  . TRP B 1 373 ? 129.691 165.443 128.810 1.00 52.73  ? 373 TRP B CG  1 
ATOM   4375 C CD1 . TRP B 1 373 ? 128.979 165.594 127.659 1.00 54.97  ? 373 TRP B CD1 1 
ATOM   4376 C CD2 . TRP B 1 373 ? 129.168 164.277 129.455 1.00 53.71  ? 373 TRP B CD2 1 
ATOM   4377 N NE1 . TRP B 1 373 ? 128.038 164.600 127.550 1.00 51.39  ? 373 TRP B NE1 1 
ATOM   4378 C CE2 . TRP B 1 373 ? 128.135 163.778 128.641 1.00 50.69  ? 373 TRP B CE2 1 
ATOM   4379 C CE3 . TRP B 1 373 ? 129.470 163.610 130.644 1.00 50.73  ? 373 TRP B CE3 1 
ATOM   4380 C CZ2 . TRP B 1 373 ? 127.403 162.646 128.978 1.00 48.31  ? 373 TRP B CZ2 1 
ATOM   4381 C CZ3 . TRP B 1 373 ? 128.743 162.488 130.976 1.00 49.77  ? 373 TRP B CZ3 1 
ATOM   4382 C CH2 . TRP B 1 373 ? 127.723 162.015 130.146 1.00 50.50  ? 373 TRP B CH2 1 
ATOM   4383 N N   . LEU B 1 374 ? 130.118 166.389 132.375 1.00 40.37  ? 374 LEU B N   1 
ATOM   4384 C CA  . LEU B 1 374 ? 129.354 165.905 133.518 1.00 41.08  ? 374 LEU B CA  1 
ATOM   4385 C C   . LEU B 1 374 ? 128.670 167.048 134.255 1.00 44.06  ? 374 LEU B C   1 
ATOM   4386 O O   . LEU B 1 374 ? 127.535 166.899 134.715 1.00 44.59  ? 374 LEU B O   1 
ATOM   4387 C CB  . LEU B 1 374 ? 130.261 165.123 134.467 1.00 39.44  ? 374 LEU B CB  1 
ATOM   4388 C CG  . LEU B 1 374 ? 129.588 164.582 135.727 1.00 35.73  ? 374 LEU B CG  1 
ATOM   4389 C CD1 . LEU B 1 374 ? 128.405 163.710 135.361 1.00 40.68  ? 374 LEU B CD1 1 
ATOM   4390 C CD2 . LEU B 1 374 ? 130.578 163.810 136.574 1.00 38.22  ? 374 LEU B CD2 1 
ATOM   4391 N N   . LEU B 1 375 ? 129.346 168.191 134.392 1.00 43.83  ? 375 LEU B N   1 
ATOM   4392 C CA  . LEU B 1 375 ? 128.732 169.335 135.060 1.00 38.94  ? 375 LEU B CA  1 
ATOM   4393 C C   . LEU B 1 375 ? 127.537 169.860 134.275 1.00 43.67  ? 375 LEU B C   1 
ATOM   4394 O O   . LEU B 1 375 ? 126.488 170.161 134.857 1.00 43.12  ? 375 LEU B O   1 
ATOM   4395 C CB  . LEU B 1 375 ? 129.763 170.441 135.268 1.00 35.69  ? 375 LEU B CB  1 
ATOM   4396 C CG  . LEU B 1 375 ? 130.807 170.198 136.357 1.00 47.02  ? 375 LEU B CG  1 
ATOM   4397 C CD1 . LEU B 1 375 ? 131.758 171.375 136.459 1.00 48.69  ? 375 LEU B CD1 1 
ATOM   4398 C CD2 . LEU B 1 375 ? 130.132 169.940 137.690 1.00 49.24  ? 375 LEU B CD2 1 
ATOM   4399 N N   . LYS B 1 376 ? 127.673 169.971 132.952 1.00 42.07  ? 376 LYS B N   1 
ATOM   4400 C CA  . LYS B 1 376 ? 126.546 170.412 132.137 1.00 42.06  ? 376 LYS B CA  1 
ATOM   4401 C C   . LYS B 1 376 ? 125.388 169.426 132.224 1.00 49.29  ? 376 LYS B C   1 
ATOM   4402 O O   . LYS B 1 376 ? 124.221 169.828 132.322 1.00 53.95  ? 376 LYS B O   1 
ATOM   4403 C CB  . LYS B 1 376 ? 126.988 170.595 130.687 1.00 46.77  ? 376 LYS B CB  1 
ATOM   4404 C CG  . LYS B 1 376 ? 128.070 171.642 130.499 1.00 46.10  ? 376 LYS B CG  1 
ATOM   4405 C CD  . LYS B 1 376 ? 128.571 171.660 129.068 1.00 52.97  ? 376 LYS B CD  1 
ATOM   4406 C CE  . LYS B 1 376 ? 129.734 172.621 128.907 1.00 66.88  ? 376 LYS B CE  1 
ATOM   4407 N NZ  . LYS B 1 376 ? 130.262 172.619 127.515 1.00 70.53  ? 376 LYS B NZ  1 
ATOM   4408 N N   . LEU B 1 377 ? 125.693 168.127 132.196 1.00 47.80  ? 377 LEU B N   1 
ATOM   4409 C CA  . LEU B 1 377 ? 124.643 167.120 132.295 1.00 41.98  ? 377 LEU B CA  1 
ATOM   4410 C C   . LEU B 1 377 ? 123.958 167.158 133.656 1.00 40.11  ? 377 LEU B C   1 
ATOM   4411 O O   . LEU B 1 377 ? 122.739 166.993 133.741 1.00 47.19  ? 377 LEU B O   1 
ATOM   4412 C CB  . LEU B 1 377 ? 125.223 165.736 132.018 1.00 38.82  ? 377 LEU B CB  1 
ATOM   4413 C CG  . LEU B 1 377 ? 124.186 164.640 131.811 1.00 40.07  ? 377 LEU B CG  1 
ATOM   4414 C CD1 . LEU B 1 377 ? 123.302 164.979 130.631 1.00 47.62  ? 377 LEU B CD1 1 
ATOM   4415 C CD2 . LEU B 1 377 ? 124.867 163.306 131.610 1.00 36.25  ? 377 LEU B CD2 1 
ATOM   4416 N N   . LEU B 1 378 ? 124.720 167.365 134.731 1.00 34.50  ? 378 LEU B N   1 
ATOM   4417 C CA  . LEU B 1 378 ? 124.120 167.494 136.056 1.00 38.61  ? 378 LEU B CA  1 
ATOM   4418 C C   . LEU B 1 378 ? 123.224 168.721 136.139 1.00 46.26  ? 378 LEU B C   1 
ATOM   4419 O O   . LEU B 1 378 ? 122.145 168.673 136.743 1.00 52.32  ? 378 LEU B O   1 
ATOM   4420 C CB  . LEU B 1 378 ? 125.209 167.563 137.126 1.00 39.76  ? 378 LEU B CB  1 
ATOM   4421 C CG  . LEU B 1 378 ? 125.896 166.265 137.546 1.00 44.49  ? 378 LEU B CG  1 
ATOM   4422 C CD1 . LEU B 1 378 ? 127.081 166.572 138.439 1.00 45.96  ? 378 LEU B CD1 1 
ATOM   4423 C CD2 . LEU B 1 378 ? 124.917 165.356 138.260 1.00 45.04  ? 378 LEU B CD2 1 
ATOM   4424 N N   . PHE B 1 379 ? 123.663 169.837 135.552 1.00 48.29  ? 379 PHE B N   1 
ATOM   4425 C CA  . PHE B 1 379 ? 122.825 171.031 135.520 1.00 45.89  ? 379 PHE B CA  1 
ATOM   4426 C C   . PHE B 1 379 ? 121.523 170.766 134.778 1.00 47.48  ? 379 PHE B C   1 
ATOM   4427 O O   . PHE B 1 379 ? 120.451 171.199 135.216 1.00 51.98  ? 379 PHE B O   1 
ATOM   4428 C CB  . PHE B 1 379 ? 123.586 172.190 134.876 1.00 42.33  ? 379 PHE B CB  1 
ATOM   4429 C CG  . PHE B 1 379 ? 122.716 173.356 134.508 1.00 48.80  ? 379 PHE B CG  1 
ATOM   4430 C CD1 . PHE B 1 379 ? 122.256 174.229 135.477 1.00 50.02  ? 379 PHE B CD1 1 
ATOM   4431 C CD2 . PHE B 1 379 ? 122.362 173.583 133.189 1.00 55.94  ? 379 PHE B CD2 1 
ATOM   4432 C CE1 . PHE B 1 379 ? 121.456 175.302 135.139 1.00 51.54  ? 379 PHE B CE1 1 
ATOM   4433 C CE2 . PHE B 1 379 ? 121.562 174.654 132.846 1.00 58.90  ? 379 PHE B CE2 1 
ATOM   4434 C CZ  . PHE B 1 379 ? 121.110 175.513 133.822 1.00 53.93  ? 379 PHE B CZ  1 
ATOM   4435 N N   . ARG B 1 380 ? 121.595 170.057 133.650 1.00 47.57  ? 380 ARG B N   1 
ATOM   4436 C CA  . ARG B 1 380 ? 120.374 169.711 132.928 1.00 47.77  ? 380 ARG B CA  1 
ATOM   4437 C C   . ARG B 1 380 ? 119.490 168.772 133.743 1.00 52.88  ? 380 ARG B C   1 
ATOM   4438 O O   . ARG B 1 380 ? 118.261 168.897 133.728 1.00 59.89  ? 380 ARG B O   1 
ATOM   4439 C CB  . ARG B 1 380 ? 120.715 169.085 131.578 1.00 45.71  ? 380 ARG B CB  1 
ATOM   4440 C CG  . ARG B 1 380 ? 121.251 170.072 130.566 1.00 50.64  ? 380 ARG B CG  1 
ATOM   4441 C CD  . ARG B 1 380 ? 120.928 169.633 129.152 1.00 58.14  ? 380 ARG B CD  1 
ATOM   4442 N NE  . ARG B 1 380 ? 121.552 168.361 128.814 1.00 67.52  ? 380 ARG B NE  1 
ATOM   4443 C CZ  . ARG B 1 380 ? 122.774 168.238 128.314 1.00 71.06  ? 380 ARG B CZ  1 
ATOM   4444 N NH1 . ARG B 1 380 ? 123.544 169.293 128.103 1.00 67.46  ? 380 ARG B NH1 1 
ATOM   4445 N NH2 . ARG B 1 380 ? 123.235 167.027 128.017 1.00 69.22  ? 380 ARG B NH2 1 
ATOM   4446 N N   . VAL B 1 381 ? 120.096 167.819 134.450 1.00 48.74  ? 381 VAL B N   1 
ATOM   4447 C CA  . VAL B 1 381 ? 119.324 166.838 135.205 1.00 45.49  ? 381 VAL B CA  1 
ATOM   4448 C C   . VAL B 1 381 ? 118.578 167.505 136.353 1.00 48.99  ? 381 VAL B C   1 
ATOM   4449 O O   . VAL B 1 381 ? 117.393 167.234 136.579 1.00 55.84  ? 381 VAL B O   1 
ATOM   4450 C CB  . VAL B 1 381 ? 120.243 165.706 135.700 1.00 43.62  ? 381 VAL B CB  1 
ATOM   4451 C CG1 . VAL B 1 381 ? 119.585 164.929 136.825 1.00 43.22  ? 381 VAL B CG1 1 
ATOM   4452 C CG2 . VAL B 1 381 ? 120.593 164.777 134.552 1.00 41.98  ? 381 VAL B CG2 1 
ATOM   4453 N N   . PHE B 1 382 ? 119.246 168.388 137.091 1.00 47.58  ? 382 PHE B N   1 
ATOM   4454 C CA  . PHE B 1 382 ? 118.605 169.044 138.226 1.00 52.42  ? 382 PHE B CA  1 
ATOM   4455 C C   . PHE B 1 382 ? 117.706 170.204 137.815 1.00 58.72  ? 382 PHE B C   1 
ATOM   4456 O O   . PHE B 1 382 ? 117.049 170.795 138.677 1.00 58.20  ? 382 PHE B O   1 
ATOM   4457 C CB  . PHE B 1 382 ? 119.661 169.513 139.225 1.00 51.29  ? 382 PHE B CB  1 
ATOM   4458 C CG  . PHE B 1 382 ? 120.150 168.421 140.131 1.00 53.93  ? 382 PHE B CG  1 
ATOM   4459 C CD1 . PHE B 1 382 ? 121.184 167.590 139.742 1.00 52.57  ? 382 PHE B CD1 1 
ATOM   4460 C CD2 . PHE B 1 382 ? 119.560 168.215 141.365 1.00 49.29  ? 382 PHE B CD2 1 
ATOM   4461 C CE1 . PHE B 1 382 ? 121.627 166.581 140.572 1.00 54.46  ? 382 PHE B CE1 1 
ATOM   4462 C CE2 . PHE B 1 382 ? 119.999 167.208 142.198 1.00 48.94  ? 382 PHE B CE2 1 
ATOM   4463 C CZ  . PHE B 1 382 ? 121.033 166.390 141.801 1.00 53.89  ? 382 PHE B CZ  1 
ATOM   4464 N N   . THR B 1 383 ? 117.666 170.538 136.528 1.00 59.06  ? 383 THR B N   1 
ATOM   4465 C CA  . THR B 1 383 ? 116.694 171.472 135.977 1.00 60.26  ? 383 THR B CA  1 
ATOM   4466 C C   . THR B 1 383 ? 115.869 170.726 134.936 1.00 61.96  ? 383 THR B C   1 
ATOM   4467 O O   . THR B 1 383 ? 115.689 171.198 133.809 1.00 61.24  ? 383 THR B O   1 
ATOM   4468 C CB  . THR B 1 383 ? 117.384 172.693 135.369 1.00 58.78  ? 383 THR B CB  1 
ATOM   4469 O OG1 . THR B 1 383 ? 118.303 172.270 134.356 1.00 56.80  ? 383 THR B OG1 1 
ATOM   4470 C CG2 . THR B 1 383 ? 118.139 173.461 136.440 1.00 45.86  ? 383 THR B CG2 1 
ATOM   4471 N N   . ALA B 1 384 ? 115.383 169.546 135.322 1.00 63.55  ? 384 ALA B N   1 
ATOM   4472 C CA  . ALA B 1 384 ? 114.874 168.567 134.362 1.00 65.84  ? 384 ALA B CA  1 
ATOM   4473 C C   . ALA B 1 384 ? 113.739 169.066 133.474 1.00 74.61  ? 384 ALA B C   1 
ATOM   4474 O O   . ALA B 1 384 ? 113.829 168.884 132.247 1.00 69.42  ? 384 ALA B O   1 
ATOM   4475 C CB  . ALA B 1 384 ? 114.456 167.304 135.119 1.00 57.99  ? 384 ALA B CB  1 
ATOM   4476 N N   . PRO B 1 385 ? 112.663 169.673 133.983 1.00 70.86  ? 385 PRO B N   1 
ATOM   4477 C CA  . PRO B 1 385 ? 111.509 169.962 133.124 1.00 65.05  ? 385 PRO B CA  1 
ATOM   4478 C C   . PRO B 1 385 ? 111.699 171.123 132.161 1.00 69.89  ? 385 PRO B C   1 
ATOM   4479 O O   . PRO B 1 385 ? 110.732 171.509 131.499 1.00 73.66  ? 385 PRO B O   1 
ATOM   4480 C CB  . PRO B 1 385 ? 110.405 170.279 134.144 1.00 50.06  ? 385 PRO B CB  1 
ATOM   4481 C CG  . PRO B 1 385 ? 111.125 170.874 135.271 1.00 53.26  ? 385 PRO B CG  1 
ATOM   4482 C CD  . PRO B 1 385 ? 112.427 170.135 135.364 1.00 56.33  ? 385 PRO B CD  1 
ATOM   4483 N N   . PHE B 1 386 ? 112.902 171.685 132.049 1.00 70.49  ? 386 PHE B N   1 
ATOM   4484 C CA  . PHE B 1 386 ? 113.137 172.850 131.208 1.00 64.97  ? 386 PHE B CA  1 
ATOM   4485 C C   . PHE B 1 386 ? 114.050 172.569 130.024 1.00 66.36  ? 386 PHE B C   1 
ATOM   4486 O O   . PHE B 1 386 ? 114.253 173.461 129.194 1.00 67.99  ? 386 PHE B O   1 
ATOM   4487 C CB  . PHE B 1 386 ? 113.719 173.993 132.044 1.00 60.46  ? 386 PHE B CB  1 
ATOM   4488 C CG  . PHE B 1 386 ? 112.845 174.404 133.190 1.00 64.34  ? 386 PHE B CG  1 
ATOM   4489 C CD1 . PHE B 1 386 ? 111.707 175.160 132.972 1.00 62.41  ? 386 PHE B CD1 1 
ATOM   4490 C CD2 . PHE B 1 386 ? 113.161 174.034 134.484 1.00 64.79  ? 386 PHE B CD2 1 
ATOM   4491 C CE1 . PHE B 1 386 ? 110.901 175.538 134.024 1.00 65.77  ? 386 PHE B CE1 1 
ATOM   4492 C CE2 . PHE B 1 386 ? 112.358 174.411 135.540 1.00 67.33  ? 386 PHE B CE2 1 
ATOM   4493 C CZ  . PHE B 1 386 ? 111.227 175.164 135.310 1.00 69.81  ? 386 PHE B CZ  1 
ATOM   4494 N N   . HIS B 1 387 ? 114.603 171.365 129.918 1.00 68.21  ? 387 HIS B N   1 
ATOM   4495 C CA  . HIS B 1 387 ? 115.462 170.999 128.804 1.00 66.11  ? 387 HIS B CA  1 
ATOM   4496 C C   . HIS B 1 387 ? 114.910 169.754 128.131 1.00 63.69  ? 387 HIS B C   1 
ATOM   4497 O O   . HIS B 1 387 ? 114.325 168.885 128.783 1.00 65.34  ? 387 HIS B O   1 
ATOM   4498 C CB  . HIS B 1 387 ? 116.901 170.733 129.255 1.00 64.29  ? 387 HIS B CB  1 
ATOM   4499 C CG  . HIS B 1 387 ? 117.459 171.787 130.158 1.00 64.24  ? 387 HIS B CG  1 
ATOM   4500 N ND1 . HIS B 1 387 ? 117.981 172.971 129.687 1.00 64.22  ? 387 HIS B ND1 1 
ATOM   4501 C CD2 . HIS B 1 387 ? 117.586 171.828 131.504 1.00 62.10  ? 387 HIS B CD2 1 
ATOM   4502 C CE1 . HIS B 1 387 ? 118.401 173.700 130.706 1.00 65.77  ? 387 HIS B CE1 1 
ATOM   4503 N NE2 . HIS B 1 387 ? 118.172 173.029 131.820 1.00 61.93  ? 387 HIS B NE2 1 
ATOM   4504 N N   . LYS B 1 388 ? 115.097 169.674 126.816 1.00 57.04  ? 388 LYS B N   1 
ATOM   4505 C CA  . LYS B 1 388 ? 114.709 168.476 126.089 1.00 60.20  ? 388 LYS B CA  1 
ATOM   4506 C C   . LYS B 1 388 ? 115.516 167.288 126.594 1.00 65.13  ? 388 LYS B C   1 
ATOM   4507 O O   . LYS B 1 388 ? 116.741 167.364 126.721 1.00 64.62  ? 388 LYS B O   1 
ATOM   4508 C CB  . LYS B 1 388 ? 114.921 168.675 124.589 1.00 66.31  ? 388 LYS B CB  1 
ATOM   4509 C CG  . LYS B 1 388 ? 114.424 167.524 123.730 1.00 68.94  ? 388 LYS B CG  1 
ATOM   4510 C CD  . LYS B 1 388 ? 114.546 167.826 122.241 1.00 68.81  ? 388 LYS B CD  1 
ATOM   4511 C CE  . LYS B 1 388 ? 115.992 167.789 121.761 1.00 69.36  ? 388 LYS B CE  1 
ATOM   4512 N NZ  . LYS B 1 388 ? 116.730 169.060 122.003 1.00 70.51  ? 388 LYS B NZ  1 
ATOM   4513 N N   . VAL B 1 389 ? 114.826 166.188 126.878 1.00 67.67  ? 389 VAL B N   1 
ATOM   4514 C CA  . VAL B 1 389 ? 115.436 165.050 127.559 1.00 60.07  ? 389 VAL B CA  1 
ATOM   4515 C C   . VAL B 1 389 ? 116.134 164.174 126.525 1.00 53.53  ? 389 VAL B C   1 
ATOM   4516 O O   . VAL B 1 389 ? 115.483 163.460 125.759 1.00 49.94  ? 389 VAL B O   1 
ATOM   4517 C CB  . VAL B 1 389 ? 114.399 164.248 128.352 1.00 54.20  ? 389 VAL B CB  1 
ATOM   4518 C CG1 . VAL B 1 389 ? 115.074 163.124 129.114 1.00 45.64  ? 389 VAL B CG1 1 
ATOM   4519 C CG2 . VAL B 1 389 ? 113.640 165.158 129.301 1.00 51.23  ? 389 VAL B CG2 1 
ATOM   4520 N N   . GLY B 1 390 ? 117.466 164.231 126.501 1.00 55.35  ? 390 GLY B N   1 
ATOM   4521 C CA  . GLY B 1 390 ? 118.257 163.292 125.739 1.00 55.04  ? 390 GLY B CA  1 
ATOM   4522 C C   . GLY B 1 390 ? 118.531 162.032 126.536 1.00 51.49  ? 390 GLY B C   1 
ATOM   4523 O O   . GLY B 1 390 ? 118.116 161.883 127.683 1.00 53.55  ? 390 GLY B O   1 
ATOM   4524 N N   . PHE B 1 391 ? 119.249 161.104 125.903 1.00 50.26  ? 391 PHE B N   1 
ATOM   4525 C CA  . PHE B 1 391 ? 119.540 159.840 126.570 1.00 41.23  ? 391 PHE B CA  1 
ATOM   4526 C C   . PHE B 1 391 ? 120.424 160.045 127.792 1.00 42.83  ? 391 PHE B C   1 
ATOM   4527 O O   . PHE B 1 391 ? 120.229 159.386 128.819 1.00 45.93  ? 391 PHE B O   1 
ATOM   4528 C CB  . PHE B 1 391 ? 120.195 158.859 125.603 1.00 44.74  ? 391 PHE B CB  1 
ATOM   4529 C CG  . PHE B 1 391 ? 120.611 157.571 126.251 1.00 47.89  ? 391 PHE B CG  1 
ATOM   4530 C CD1 . PHE B 1 391 ? 119.700 156.548 126.427 1.00 45.87  ? 391 PHE B CD1 1 
ATOM   4531 C CD2 . PHE B 1 391 ? 121.908 157.388 126.693 1.00 46.39  ? 391 PHE B CD2 1 
ATOM   4532 C CE1 . PHE B 1 391 ? 120.077 155.368 127.029 1.00 45.55  ? 391 PHE B CE1 1 
ATOM   4533 C CE2 . PHE B 1 391 ? 122.287 156.211 127.294 1.00 45.74  ? 391 PHE B CE2 1 
ATOM   4534 C CZ  . PHE B 1 391 ? 121.370 155.199 127.461 1.00 48.89  ? 391 PHE B CZ  1 
ATOM   4535 N N   . ALA B 1 392 ? 121.408 160.940 127.697 1.00 46.53  ? 392 ALA B N   1 
ATOM   4536 C CA  . ALA B 1 392 ? 122.341 161.134 128.801 1.00 39.41  ? 392 ALA B CA  1 
ATOM   4537 C C   . ALA B 1 392 ? 121.631 161.644 130.047 1.00 42.47  ? 392 ALA B C   1 
ATOM   4538 O O   . ALA B 1 392 ? 121.947 161.224 131.165 1.00 39.27  ? 392 ALA B O   1 
ATOM   4539 C CB  . ALA B 1 392 ? 123.453 162.094 128.386 1.00 35.44  ? 392 ALA B CB  1 
ATOM   4540 N N   . ASP B 1 393 ? 120.668 162.552 129.874 1.00 48.38  ? 393 ASP B N   1 
ATOM   4541 C CA  . ASP B 1 393 ? 119.939 163.097 131.016 1.00 38.59  ? 393 ASP B CA  1 
ATOM   4542 C C   . ASP B 1 393 ? 119.165 162.007 131.744 1.00 39.18  ? 393 ASP B C   1 
ATOM   4543 O O   . ASP B 1 393 ? 119.245 161.886 132.971 1.00 42.76  ? 393 ASP B O   1 
ATOM   4544 C CB  . ASP B 1 393 ? 118.993 164.201 130.549 1.00 42.48  ? 393 ASP B CB  1 
ATOM   4545 C CG  . ASP B 1 393 ? 119.660 165.178 129.610 1.00 59.26  ? 393 ASP B CG  1 
ATOM   4546 O OD1 . ASP B 1 393 ? 119.994 164.779 128.476 1.00 55.16  ? 393 ASP B OD1 1 
ATOM   4547 O OD2 . ASP B 1 393 ? 119.849 166.347 130.003 1.00 72.03  ? 393 ASP B OD2 1 
ATOM   4548 N N   . PHE B 1 394 ? 118.413 161.197 130.996 1.00 38.97  ? 394 PHE B N   1 
ATOM   4549 C CA  . PHE B 1 394 ? 117.644 160.117 131.605 1.00 34.34  ? 394 PHE B CA  1 
ATOM   4550 C C   . PHE B 1 394 ? 118.561 159.091 132.259 1.00 37.68  ? 394 PHE B C   1 
ATOM   4551 O O   . PHE B 1 394 ? 118.280 158.600 133.360 1.00 40.67  ? 394 PHE B O   1 
ATOM   4552 C CB  . PHE B 1 394 ? 116.749 159.462 130.550 1.00 31.71  ? 394 PHE B CB  1 
ATOM   4553 C CG  . PHE B 1 394 ? 116.867 157.966 130.491 1.00 36.81  ? 394 PHE B CG  1 
ATOM   4554 C CD1 . PHE B 1 394 ? 116.150 157.163 131.359 1.00 42.58  ? 394 PHE B CD1 1 
ATOM   4555 C CD2 . PHE B 1 394 ? 117.685 157.363 129.555 1.00 36.92  ? 394 PHE B CD2 1 
ATOM   4556 C CE1 . PHE B 1 394 ? 116.260 155.796 131.301 1.00 40.69  ? 394 PHE B CE1 1 
ATOM   4557 C CE2 . PHE B 1 394 ? 117.796 155.995 129.497 1.00 36.19  ? 394 PHE B CE2 1 
ATOM   4558 C CZ  . PHE B 1 394 ? 117.084 155.212 130.372 1.00 41.43  ? 394 PHE B CZ  1 
ATOM   4559 N N   . TRP B 1 395 ? 119.664 158.750 131.591 1.00 35.18  ? 395 TRP B N   1 
ATOM   4560 C CA  . TRP B 1 395 ? 120.588 157.768 132.144 1.00 29.76  ? 395 TRP B CA  1 
ATOM   4561 C C   . TRP B 1 395 ? 121.199 158.260 133.449 1.00 31.84  ? 395 TRP B C   1 
ATOM   4562 O O   . TRP B 1 395 ? 121.256 157.513 134.431 1.00 37.06  ? 395 TRP B O   1 
ATOM   4563 C CB  . TRP B 1 395 ? 121.675 157.443 131.122 1.00 31.50  ? 395 TRP B CB  1 
ATOM   4564 C CG  . TRP B 1 395 ? 122.649 156.411 131.587 1.00 36.95  ? 395 TRP B CG  1 
ATOM   4565 C CD1 . TRP B 1 395 ? 122.525 155.059 131.476 1.00 35.57  ? 395 TRP B CD1 1 
ATOM   4566 C CD2 . TRP B 1 395 ? 123.906 156.646 132.230 1.00 37.57  ? 395 TRP B CD2 1 
ATOM   4567 N NE1 . TRP B 1 395 ? 123.622 154.437 132.015 1.00 35.61  ? 395 TRP B NE1 1 
ATOM   4568 C CE2 . TRP B 1 395 ? 124.485 155.391 132.485 1.00 34.90  ? 395 TRP B CE2 1 
ATOM   4569 C CE3 . TRP B 1 395 ? 124.595 157.799 132.618 1.00 35.75  ? 395 TRP B CE3 1 
ATOM   4570 C CZ2 . TRP B 1 395 ? 125.720 155.254 133.108 1.00 34.91  ? 395 TRP B CZ2 1 
ATOM   4571 C CZ3 . TRP B 1 395 ? 125.817 157.661 133.236 1.00 34.54  ? 395 TRP B CZ3 1 
ATOM   4572 C CH2 . TRP B 1 395 ? 126.368 156.399 133.476 1.00 36.19  ? 395 TRP B CH2 1 
ATOM   4573 N N   . LEU B 1 396 ? 121.642 159.518 133.488 1.00 29.80  ? 396 LEU B N   1 
ATOM   4574 C CA  . LEU B 1 396 ? 122.221 160.057 134.714 1.00 29.77  ? 396 LEU B CA  1 
ATOM   4575 C C   . LEU B 1 396 ? 121.172 160.184 135.812 1.00 32.72  ? 396 LEU B C   1 
ATOM   4576 O O   . LEU B 1 396 ? 121.477 159.990 136.994 1.00 33.75  ? 396 LEU B O   1 
ATOM   4577 C CB  . LEU B 1 396 ? 122.879 161.407 134.437 1.00 34.35  ? 396 LEU B CB  1 
ATOM   4578 C CG  . LEU B 1 396 ? 123.647 162.027 135.605 1.00 36.18  ? 396 LEU B CG  1 
ATOM   4579 C CD1 . LEU B 1 396 ? 124.817 161.147 136.006 1.00 31.95  ? 396 LEU B CD1 1 
ATOM   4580 C CD2 . LEU B 1 396 ? 124.119 163.420 135.252 1.00 30.05  ? 396 LEU B CD2 1 
ATOM   4581 N N   . ALA B 1 397 ? 119.930 160.501 135.444 1.00 33.14  ? 397 ALA B N   1 
ATOM   4582 C CA  . ALA B 1 397 ? 118.866 160.548 136.439 1.00 29.74  ? 397 ALA B CA  1 
ATOM   4583 C C   . ALA B 1 397 ? 118.614 159.172 137.043 1.00 37.38  ? 397 ALA B C   1 
ATOM   4584 O O   . ALA B 1 397 ? 118.374 159.053 138.248 1.00 40.34  ? 397 ALA B O   1 
ATOM   4585 C CB  . ALA B 1 397 ? 117.593 161.114 135.818 1.00 27.41  ? 397 ALA B CB  1 
ATOM   4586 N N   . ASP B 1 398 ? 118.666 158.117 136.225 1.00 34.31  ? 398 ASP B N   1 
ATOM   4587 C CA  . ASP B 1 398 ? 118.518 156.764 136.760 1.00 28.36  ? 398 ASP B CA  1 
ATOM   4588 C C   . ASP B 1 398 ? 119.708 156.369 137.629 1.00 34.50  ? 398 ASP B C   1 
ATOM   4589 O O   . ASP B 1 398 ? 119.543 155.687 138.652 1.00 39.84  ? 398 ASP B O   1 
ATOM   4590 C CB  . ASP B 1 398 ? 118.329 155.768 135.622 1.00 29.66  ? 398 ASP B CB  1 
ATOM   4591 C CG  . ASP B 1 398 ? 116.873 155.462 135.356 1.00 48.24  ? 398 ASP B CG  1 
ATOM   4592 O OD1 . ASP B 1 398 ? 116.065 155.537 136.304 1.00 48.53  ? 398 ASP B OD1 1 
ATOM   4593 O OD2 . ASP B 1 398 ? 116.534 155.140 134.203 1.00 50.68  ? 398 ASP B OD2 1 
ATOM   4594 N N   . GLN B 1 399 ? 120.915 156.780 137.240 1.00 31.84  ? 399 GLN B N   1 
ATOM   4595 C CA  . GLN B 1 399 ? 122.071 156.535 138.095 1.00 27.72  ? 399 GLN B CA  1 
ATOM   4596 C C   . GLN B 1 399 ? 121.890 157.207 139.449 1.00 37.66  ? 399 GLN B C   1 
ATOM   4597 O O   . GLN B 1 399 ? 122.209 156.622 140.488 1.00 43.73  ? 399 GLN B O   1 
ATOM   4598 C CB  . GLN B 1 399 ? 123.354 157.028 137.426 1.00 31.65  ? 399 GLN B CB  1 
ATOM   4599 C CG  . GLN B 1 399 ? 123.604 156.493 136.029 1.00 30.07  ? 399 GLN B CG  1 
ATOM   4600 C CD  . GLN B 1 399 ? 123.295 155.022 135.890 1.00 38.03  ? 399 GLN B CD  1 
ATOM   4601 O OE1 . GLN B 1 399 ? 124.017 154.173 136.405 1.00 46.03  ? 399 GLN B OE1 1 
ATOM   4602 N NE2 . GLN B 1 399 ? 122.220 154.711 135.180 1.00 35.93  ? 399 GLN B NE2 1 
ATOM   4603 N N   . LEU B 1 400 ? 121.368 158.436 139.457 1.00 38.09  ? 400 LEU B N   1 
ATOM   4604 C CA  . LEU B 1 400 ? 121.066 159.105 140.720 1.00 38.42  ? 400 LEU B CA  1 
ATOM   4605 C C   . LEU B 1 400 ? 119.961 158.388 141.485 1.00 38.81  ? 400 LEU B C   1 
ATOM   4606 O O   . LEU B 1 400 ? 119.977 158.362 142.720 1.00 42.85  ? 400 LEU B O   1 
ATOM   4607 C CB  . LEU B 1 400 ? 120.673 160.560 140.470 1.00 37.66  ? 400 LEU B CB  1 
ATOM   4608 C CG  . LEU B 1 400 ? 121.732 161.477 139.861 1.00 38.53  ? 400 LEU B CG  1 
ATOM   4609 C CD1 . LEU B 1 400 ? 121.210 162.898 139.782 1.00 43.67  ? 400 LEU B CD1 1 
ATOM   4610 C CD2 . LEU B 1 400 ? 123.017 161.418 140.661 1.00 49.35  ? 400 LEU B CD2 1 
ATOM   4611 N N   . ASN B 1 401 ? 118.987 157.822 140.775 1.00 38.97  ? 401 ASN B N   1 
ATOM   4612 C CA  . ASN B 1 401 ? 117.942 157.053 141.439 1.00 38.84  ? 401 ASN B CA  1 
ATOM   4613 C C   . ASN B 1 401 ? 118.534 155.864 142.179 1.00 38.73  ? 401 ASN B C   1 
ATOM   4614 O O   . ASN B 1 401 ? 118.079 155.510 143.273 1.00 48.33  ? 401 ASN B O   1 
ATOM   4615 C CB  . ASN B 1 401 ? 116.904 156.592 140.418 1.00 37.87  ? 401 ASN B CB  1 
ATOM   4616 C CG  . ASN B 1 401 ? 115.524 156.467 141.011 1.00 46.61  ? 401 ASN B CG  1 
ATOM   4617 O OD1 . ASN B 1 401 ? 115.369 156.220 142.206 1.00 50.47  ? 401 ASN B OD1 1 
ATOM   4618 N ND2 . ASN B 1 401 ? 114.507 156.643 140.179 1.00 52.02  ? 401 ASN B ND2 1 
ATOM   4619 N N   . SER B 1 402 ? 119.547 155.233 141.592 1.00 37.77  ? 402 SER B N   1 
ATOM   4620 C CA  . SER B 1 402 ? 120.258 154.157 142.277 1.00 40.38  ? 402 SER B CA  1 
ATOM   4621 C C   . SER B 1 402 ? 121.207 154.658 143.361 1.00 43.00  ? 402 SER B C   1 
ATOM   4622 O O   . SER B 1 402 ? 121.484 153.918 144.311 1.00 42.14  ? 402 SER B O   1 
ATOM   4623 C CB  . SER B 1 402 ? 121.037 153.315 141.269 1.00 36.45  ? 402 SER B CB  1 
ATOM   4624 O OG  . SER B 1 402 ? 120.153 152.603 140.424 1.00 39.77  ? 402 SER B OG  1 
ATOM   4625 N N   . LEU B 1 403 ? 121.715 155.884 143.240 1.00 42.49  ? 403 LEU B N   1 
ATOM   4626 C CA  . LEU B 1 403 ? 122.705 156.423 144.166 1.00 40.00  ? 403 LEU B CA  1 
ATOM   4627 C C   . LEU B 1 403 ? 122.117 157.312 145.255 1.00 46.15  ? 403 LEU B C   1 
ATOM   4628 O O   . LEU B 1 403 ? 122.883 157.913 146.011 1.00 53.68  ? 403 LEU B O   1 
ATOM   4629 C CB  . LEU B 1 403 ? 123.762 157.219 143.397 1.00 38.88  ? 403 LEU B CB  1 
ATOM   4630 C CG  . LEU B 1 403 ? 124.749 156.454 142.523 1.00 39.62  ? 403 LEU B CG  1 
ATOM   4631 C CD1 . LEU B 1 403 ? 125.525 157.429 141.665 1.00 41.75  ? 403 LEU B CD1 1 
ATOM   4632 C CD2 . LEU B 1 403 ? 125.686 155.628 143.381 1.00 33.63  ? 403 LEU B CD2 1 
ATOM   4633 N N   . SER B 1 404 ? 120.789 157.428 145.341 1.00 51.05  ? 404 SER B N   1 
ATOM   4634 C CA  . SER B 1 404 ? 120.162 158.318 146.320 1.00 51.40  ? 404 SER B CA  1 
ATOM   4635 C C   . SER B 1 404 ? 120.656 158.110 147.749 1.00 49.26  ? 404 SER B C   1 
ATOM   4636 O O   . SER B 1 404 ? 120.445 158.984 148.600 1.00 51.59  ? 404 SER B O   1 
ATOM   4637 C CB  . SER B 1 404 ? 118.642 158.145 146.282 1.00 50.63  ? 404 SER B CB  1 
ATOM   4638 O OG  . SER B 1 404 ? 118.273 156.814 146.590 1.00 58.17  ? 404 SER B OG  1 
ATOM   4639 N N   . VAL B 1 405 ? 121.304 156.981 148.040 1.00 46.44  ? 405 VAL B N   1 
ATOM   4640 C CA  . VAL B 1 405 ? 121.912 156.808 149.355 1.00 51.17  ? 405 VAL B CA  1 
ATOM   4641 C C   . VAL B 1 405 ? 123.001 157.847 149.576 1.00 56.63  ? 405 VAL B C   1 
ATOM   4642 O O   . VAL B 1 405 ? 123.248 158.268 150.711 1.00 62.27  ? 405 VAL B O   1 
ATOM   4643 C CB  . VAL B 1 405 ? 122.457 155.377 149.514 1.00 50.36  ? 405 VAL B CB  1 
ATOM   4644 C CG1 . VAL B 1 405 ? 122.805 155.102 150.965 1.00 50.07  ? 405 VAL B CG1 1 
ATOM   4645 C CG2 . VAL B 1 405 ? 121.446 154.368 149.005 1.00 56.72  ? 405 VAL B CG2 1 
ATOM   4646 N N   . ILE B 1 406 ? 123.663 158.286 148.502 1.00 56.79  ? 406 ILE B N   1 
ATOM   4647 C CA  . ILE B 1 406 ? 124.655 159.350 148.621 1.00 48.12  ? 406 ILE B CA  1 
ATOM   4648 C C   . ILE B 1 406 ? 123.997 160.645 149.077 1.00 50.73  ? 406 ILE B C   1 
ATOM   4649 O O   . ILE B 1 406 ? 124.521 161.349 149.947 1.00 53.64  ? 406 ILE B O   1 
ATOM   4650 C CB  . ILE B 1 406 ? 125.408 159.534 147.291 1.00 42.33  ? 406 ILE B CB  1 
ATOM   4651 C CG1 . ILE B 1 406 ? 126.264 158.305 146.990 1.00 43.50  ? 406 ILE B CG1 1 
ATOM   4652 C CG2 . ILE B 1 406 ? 126.265 160.785 147.330 1.00 41.13  ? 406 ILE B CG2 1 
ATOM   4653 C CD1 . ILE B 1 406 ? 127.167 158.472 145.792 1.00 43.36  ? 406 ILE B CD1 1 
ATOM   4654 N N   . LEU B 1 407 ? 122.842 160.984 148.499 1.00 53.96  ? 407 LEU B N   1 
ATOM   4655 C CA  . LEU B 1 407 ? 122.128 162.185 148.925 1.00 57.25  ? 407 LEU B CA  1 
ATOM   4656 C C   . LEU B 1 407 ? 121.659 162.063 150.368 1.00 56.52  ? 407 LEU B C   1 
ATOM   4657 O O   . LEU B 1 407 ? 121.731 163.028 151.138 1.00 62.76  ? 407 LEU B O   1 
ATOM   4658 C CB  . LEU B 1 407 ? 120.938 162.456 148.002 1.00 58.98  ? 407 LEU B CB  1 
ATOM   4659 C CG  . LEU B 1 407 ? 121.206 162.963 146.582 1.00 67.53  ? 407 LEU B CG  1 
ATOM   4660 C CD1 . LEU B 1 407 ? 121.564 161.825 145.634 1.00 58.26  ? 407 LEU B CD1 1 
ATOM   4661 C CD2 . LEU B 1 407 ? 120.007 163.736 146.062 1.00 62.28  ? 407 LEU B CD2 1 
ATOM   4662 N N   . MET B 1 408 ? 121.168 160.883 150.751 1.00 57.70  ? 408 MET B N   1 
ATOM   4663 C CA  . MET B 1 408 ? 120.739 160.683 152.132 1.00 59.75  ? 408 MET B CA  1 
ATOM   4664 C C   . MET B 1 408 ? 121.905 160.846 153.101 1.00 61.27  ? 408 MET B C   1 
ATOM   4665 O O   . MET B 1 408 ? 121.768 161.486 154.150 1.00 67.22  ? 408 MET B O   1 
ATOM   4666 C CB  . MET B 1 408 ? 120.099 159.306 152.293 1.00 60.70  ? 408 MET B CB  1 
ATOM   4667 C CG  . MET B 1 408 ? 118.951 159.045 151.340 1.00 57.52  ? 408 MET B CG  1 
ATOM   4668 S SD  . MET B 1 408 ? 117.695 160.328 151.409 1.00 75.53  ? 408 MET B SD  1 
ATOM   4669 C CE  . MET B 1 408 ? 117.074 160.085 153.065 1.00 72.71  ? 408 MET B CE  1 
ATOM   4670 N N   . ASP B 1 409 ? 123.064 160.280 152.761 1.00 64.62  ? 409 ASP B N   1 
ATOM   4671 C CA  . ASP B 1 409 ? 124.236 160.408 153.620 1.00 65.63  ? 409 ASP B CA  1 
ATOM   4672 C C   . ASP B 1 409 ? 124.736 161.845 153.669 1.00 70.10  ? 409 ASP B C   1 
ATOM   4673 O O   . ASP B 1 409 ? 125.202 162.306 154.713 1.00 74.84  ? 409 ASP B O   1 
ATOM   4674 C CB  . ASP B 1 409 ? 125.342 159.470 153.143 1.00 62.26  ? 409 ASP B CB  1 
ATOM   4675 C CG  . ASP B 1 409 ? 125.035 158.018 153.432 1.00 63.77  ? 409 ASP B CG  1 
ATOM   4676 O OD1 . ASP B 1 409 ? 124.006 157.744 154.083 1.00 62.36  ? 409 ASP B OD1 1 
ATOM   4677 O OD2 . ASP B 1 409 ? 125.822 157.148 153.008 1.00 64.16  ? 409 ASP B OD2 1 
ATOM   4678 N N   . LEU B 1 410 ? 124.659 162.567 152.550 1.00 71.70  ? 410 LEU B N   1 
ATOM   4679 C CA  . LEU B 1 410 ? 125.032 163.978 152.559 1.00 72.77  ? 410 LEU B CA  1 
ATOM   4680 C C   . LEU B 1 410 ? 124.116 164.783 153.471 1.00 72.36  ? 410 LEU B C   1 
ATOM   4681 O O   . LEU B 1 410 ? 124.580 165.649 154.221 1.00 77.62  ? 410 LEU B O   1 
ATOM   4682 C CB  . LEU B 1 410 ? 125.002 164.539 151.139 1.00 72.33  ? 410 LEU B CB  1 
ATOM   4683 C CG  . LEU B 1 410 ? 125.184 166.051 151.006 1.00 75.12  ? 410 LEU B CG  1 
ATOM   4684 C CD1 . LEU B 1 410 ? 126.522 166.484 151.580 1.00 83.47  ? 410 LEU B CD1 1 
ATOM   4685 C CD2 . LEU B 1 410 ? 125.056 166.476 149.554 1.00 72.49  ? 410 LEU B CD2 1 
ATOM   4686 N N   . GLU B 1 411 ? 122.810 164.515 153.419 1.00 72.13  ? 411 GLU B N   1 
ATOM   4687 C CA  . GLU B 1 411 ? 121.883 165.198 154.315 1.00 72.75  ? 411 GLU B CA  1 
ATOM   4688 C C   . GLU B 1 411 ? 122.174 164.856 155.772 1.00 78.15  ? 411 GLU B C   1 
ATOM   4689 O O   . GLU B 1 411 ? 122.130 165.731 156.647 1.00 81.10  ? 411 GLU B O   1 
ATOM   4690 C CB  . GLU B 1 411 ? 120.442 164.840 153.948 1.00 69.37  ? 411 GLU B CB  1 
ATOM   4691 C CG  . GLU B 1 411 ? 119.381 165.577 154.748 1.00 76.57  ? 411 GLU B CG  1 
ATOM   4692 C CD  . GLU B 1 411 ? 118.964 164.830 155.998 1.00 84.35  ? 411 GLU B CD  1 
ATOM   4693 O OE1 . GLU B 1 411 ? 119.400 163.673 156.174 1.00 84.39  ? 411 GLU B OE1 1 
ATOM   4694 O OE2 . GLU B 1 411 ? 118.199 165.397 156.804 1.00 86.70  ? 411 GLU B OE2 1 
ATOM   4695 N N   . TYR B 1 412 ? 122.476 163.586 156.050 1.00 77.12  ? 412 TYR B N   1 
ATOM   4696 C CA  . TYR B 1 412 ? 122.814 163.187 157.413 1.00 78.75  ? 412 TYR B CA  1 
ATOM   4697 C C   . TYR B 1 412 ? 124.101 163.853 157.881 1.00 87.09  ? 412 TYR B C   1 
ATOM   4698 O O   . TYR B 1 412 ? 124.230 164.203 159.057 1.00 93.79  ? 412 TYR B O   1 
ATOM   4699 C CB  . TYR B 1 412 ? 122.936 161.668 157.508 1.00 79.12  ? 412 TYR B CB  1 
ATOM   4700 C CG  . TYR B 1 412 ? 123.419 161.182 158.855 1.00 84.55  ? 412 TYR B CG  1 
ATOM   4701 C CD1 . TYR B 1 412 ? 122.556 161.111 159.939 1.00 86.07  ? 412 TYR B CD1 1 
ATOM   4702 C CD2 . TYR B 1 412 ? 124.739 160.794 159.044 1.00 83.12  ? 412 TYR B CD2 1 
ATOM   4703 C CE1 . TYR B 1 412 ? 122.992 160.670 161.173 1.00 86.65  ? 412 TYR B CE1 1 
ATOM   4704 C CE2 . TYR B 1 412 ? 125.184 160.353 160.276 1.00 85.88  ? 412 TYR B CE2 1 
ATOM   4705 C CZ  . TYR B 1 412 ? 124.306 160.293 161.335 1.00 85.46  ? 412 TYR B CZ  1 
ATOM   4706 O OH  . TYR B 1 412 ? 124.741 159.853 162.562 1.00 86.85  ? 412 TYR B OH  1 
ATOM   4707 N N   . MET B 1 413 ? 125.070 164.014 156.980 1.00 86.96  ? 413 MET B N   1 
ATOM   4708 C CA  . MET B 1 413 ? 126.314 164.692 157.329 1.00 84.52  ? 413 MET B CA  1 
ATOM   4709 C C   . MET B 1 413 ? 126.078 166.173 157.597 1.00 87.08  ? 413 MET B C   1 
ATOM   4710 O O   . MET B 1 413 ? 126.684 166.749 158.507 1.00 91.64  ? 413 MET B O   1 
ATOM   4711 C CB  . MET B 1 413 ? 127.339 164.501 156.211 1.00 81.74  ? 413 MET B CB  1 
ATOM   4712 C CG  . MET B 1 413 ? 128.704 165.088 156.503 1.00 86.66  ? 413 MET B CG  1 
ATOM   4713 S SD  . MET B 1 413 ? 129.870 164.828 155.153 1.00 104.60 ? 413 MET B SD  1 
ATOM   4714 C CE  . MET B 1 413 ? 131.337 165.602 155.825 1.00 76.48  ? 413 MET B CE  1 
ATOM   4715 N N   . ILE B 1 414 ? 125.207 166.806 156.809 1.00 86.11  ? 414 ILE B N   1 
ATOM   4716 C CA  . ILE B 1 414 ? 124.872 168.208 157.042 1.00 83.53  ? 414 ILE B CA  1 
ATOM   4717 C C   . ILE B 1 414 ? 124.196 168.376 158.396 1.00 87.52  ? 414 ILE B C   1 
ATOM   4718 O O   . ILE B 1 414 ? 124.513 169.300 159.154 1.00 92.75  ? 414 ILE B O   1 
ATOM   4719 C CB  . ILE B 1 414 ? 123.991 168.747 155.900 1.00 79.37  ? 414 ILE B CB  1 
ATOM   4720 C CG1 . ILE B 1 414 ? 124.781 168.797 154.593 1.00 83.23  ? 414 ILE B CG1 1 
ATOM   4721 C CG2 . ILE B 1 414 ? 123.454 170.124 156.246 1.00 80.06  ? 414 ILE B CG2 1 
ATOM   4722 C CD1 . ILE B 1 414 ? 123.942 169.157 153.389 1.00 75.84  ? 414 ILE B CD1 1 
ATOM   4723 N N   . CYS B 1 415 ? 123.253 167.490 158.720 1.00 88.24  ? 415 CYS B N   1 
ATOM   4724 C CA  . CYS B 1 415 ? 122.600 167.560 160.024 1.00 94.21  ? 415 CYS B CA  1 
ATOM   4725 C C   . CYS B 1 415 ? 123.582 167.281 161.156 1.00 94.57  ? 415 CYS B C   1 
ATOM   4726 O O   . CYS B 1 415 ? 123.538 167.939 162.201 1.00 98.07  ? 415 CYS B O   1 
ATOM   4727 C CB  . CYS B 1 415 ? 121.425 166.585 160.079 1.00 97.89  ? 415 CYS B CB  1 
ATOM   4728 S SG  . CYS B 1 415 ? 120.060 167.006 158.971 1.00 112.19 ? 415 CYS B SG  1 
ATOM   4729 N N   . PHE B 1 416 ? 124.472 166.304 160.967 1.00 91.98  ? 416 PHE B N   1 
ATOM   4730 C CA  . PHE B 1 416 ? 125.427 165.937 162.007 1.00 96.31  ? 416 PHE B CA  1 
ATOM   4731 C C   . PHE B 1 416 ? 126.409 167.068 162.285 1.00 97.97  ? 416 PHE B C   1 
ATOM   4732 O O   . PHE B 1 416 ? 126.701 167.372 163.447 1.00 101.29 ? 416 PHE B O   1 
ATOM   4733 C CB  . PHE B 1 416 ? 126.169 164.664 161.596 1.00 99.20  ? 416 PHE B CB  1 
ATOM   4734 C CG  . PHE B 1 416 ? 127.023 164.073 162.683 1.00 101.75 ? 416 PHE B CG  1 
ATOM   4735 C CD1 . PHE B 1 416 ? 126.473 163.227 163.630 1.00 101.47 ? 416 PHE B CD1 1 
ATOM   4736 C CD2 . PHE B 1 416 ? 128.377 164.347 162.745 1.00 96.66  ? 416 PHE B CD2 1 
ATOM   4737 C CE1 . PHE B 1 416 ? 127.255 162.677 164.625 1.00 102.30 ? 416 PHE B CE1 1 
ATOM   4738 C CE2 . PHE B 1 416 ? 129.164 163.800 163.738 1.00 96.60  ? 416 PHE B CE2 1 
ATOM   4739 C CZ  . PHE B 1 416 ? 128.602 162.964 164.679 1.00 99.97  ? 416 PHE B CZ  1 
ATOM   4740 N N   . TYR B 1 417 ? 126.918 167.710 161.238 1.00 96.71  ? 417 TYR B N   1 
ATOM   4741 C CA  . TYR B 1 417 ? 127.868 168.804 161.384 1.00 95.21  ? 417 TYR B CA  1 
ATOM   4742 C C   . TYR B 1 417 ? 127.202 170.129 161.731 1.00 100.06 ? 417 TYR B C   1 
ATOM   4743 O O   . TYR B 1 417 ? 127.869 171.167 161.695 1.00 101.32 ? 417 TYR B O   1 
ATOM   4744 C CB  . TYR B 1 417 ? 128.691 168.961 160.103 1.00 89.28  ? 417 TYR B CB  1 
ATOM   4745 C CG  . TYR B 1 417 ? 129.891 168.047 160.031 1.00 93.25  ? 417 TYR B CG  1 
ATOM   4746 C CD1 . TYR B 1 417 ? 129.745 166.693 159.766 1.00 98.04  ? 417 TYR B CD1 1 
ATOM   4747 C CD2 . TYR B 1 417 ? 131.173 168.541 160.223 1.00 90.80  ? 417 TYR B CD2 1 
ATOM   4748 C CE1 . TYR B 1 417 ? 130.841 165.858 159.699 1.00 94.85  ? 417 TYR B CE1 1 
ATOM   4749 C CE2 . TYR B 1 417 ? 132.273 167.714 160.158 1.00 88.87  ? 417 TYR B CE2 1 
ATOM   4750 C CZ  . TYR B 1 417 ? 132.102 166.374 159.896 1.00 89.65  ? 417 TYR B CZ  1 
ATOM   4751 O OH  . TYR B 1 417 ? 133.199 165.550 159.832 1.00 87.61  ? 417 TYR B OH  1 
ATOM   4752 N N   . SER B 1 418 ? 125.911 170.123 162.057 1.00 102.39 ? 418 SER B N   1 
ATOM   4753 C CA  . SER B 1 418 ? 125.220 171.355 162.411 1.00 101.18 ? 418 SER B CA  1 
ATOM   4754 C C   . SER B 1 418 ? 124.465 171.208 163.725 1.00 102.08 ? 418 SER B C   1 
ATOM   4755 O O   . SER B 1 418 ? 124.294 172.187 164.458 1.00 104.54 ? 418 SER B O   1 
ATOM   4756 C CB  . SER B 1 418 ? 124.262 171.768 161.292 1.00 99.57  ? 418 SER B CB  1 
ATOM   4757 O OG  . SER B 1 418 ? 124.963 171.994 160.081 1.00 95.95  ? 418 SER B OG  1 
ATOM   4758 N N   . LEU B 1 419 ? 124.011 169.994 164.036 1.00 103.65 ? 419 LEU B N   1 
ATOM   4759 C CA  . LEU B 1 419 ? 123.199 169.751 165.221 1.00 107.43 ? 419 LEU B CA  1 
ATOM   4760 C C   . LEU B 1 419 ? 123.906 168.867 166.241 1.00 106.59 ? 419 LEU B C   1 
ATOM   4761 O O   . LEU B 1 419 ? 124.065 169.265 167.398 1.00 107.07 ? 419 LEU B O   1 
ATOM   4762 C CB  . LEU B 1 419 ? 121.853 169.129 164.821 1.00 110.91 ? 419 LEU B CB  1 
ATOM   4763 C CG  . LEU B 1 419 ? 120.727 170.069 164.376 1.00 109.32 ? 419 LEU B CG  1 
ATOM   4764 C CD1 . LEU B 1 419 ? 121.033 170.732 163.041 1.00 106.07 ? 419 LEU B CD1 1 
ATOM   4765 C CD2 . LEU B 1 419 ? 119.407 169.319 164.311 1.00 99.98  ? 419 LEU B CD2 1 
ATOM   4766 N N   . GLU B 1 420 ? 124.336 167.674 165.846 1.00 107.47 ? 420 GLU B N   1 
ATOM   4767 C CA  . GLU B 1 420 ? 124.929 166.705 166.766 1.00 110.10 ? 420 GLU B CA  1 
ATOM   4768 C C   . GLU B 1 420 ? 126.401 166.525 166.404 1.00 111.21 ? 420 GLU B C   1 
ATOM   4769 O O   . GLU B 1 420 ? 126.764 165.632 165.637 1.00 112.75 ? 420 GLU B O   1 
ATOM   4770 C CB  . GLU B 1 420 ? 124.176 165.377 166.720 1.00 113.98 ? 420 GLU B CB  1 
ATOM   4771 C CG  . GLU B 1 420 ? 124.707 164.330 167.687 1.00 118.63 ? 420 GLU B CG  1 
ATOM   4772 C CD  . GLU B 1 420 ? 123.982 163.007 167.569 1.00 126.12 ? 420 GLU B CD  1 
ATOM   4773 O OE1 . GLU B 1 420 ? 123.040 162.915 166.754 1.00 128.85 ? 420 GLU B OE1 1 
ATOM   4774 O OE2 . GLU B 1 420 ? 124.353 162.058 168.291 1.00 126.08 ? 420 GLU B OE2 1 
ATOM   4775 N N   . LEU B 1 421 ? 127.248 167.384 166.965 1.00 111.32 ? 421 LEU B N   1 
ATOM   4776 C CA  . LEU B 1 421 ? 128.695 167.257 166.811 1.00 110.05 ? 421 LEU B CA  1 
ATOM   4777 C C   . LEU B 1 421 ? 129.355 168.101 167.885 1.00 114.38 ? 421 LEU B C   1 
ATOM   4778 O O   . LEU B 1 421 ? 129.105 169.308 167.961 1.00 115.97 ? 421 LEU B O   1 
ATOM   4779 C CB  . LEU B 1 421 ? 129.152 167.698 165.421 1.00 109.28 ? 421 LEU B CB  1 
ATOM   4780 C CG  . LEU B 1 421 ? 130.660 167.628 165.168 1.00 106.37 ? 421 LEU B CG  1 
ATOM   4781 C CD1 . LEU B 1 421 ? 131.193 166.239 165.468 1.00 108.71 ? 421 LEU B CD1 1 
ATOM   4782 C CD2 . LEU B 1 421 ? 130.985 168.024 163.740 1.00 98.31  ? 421 LEU B CD2 1 
ATOM   4783 N N   . LYS B 1 422 ? 130.189 167.476 168.711 1.00 117.06 ? 422 LYS B N   1 
ATOM   4784 C CA  . LYS B 1 422 ? 130.903 168.187 169.767 1.00 120.52 ? 422 LYS B CA  1 
ATOM   4785 C C   . LYS B 1 422 ? 132.190 168.738 169.169 1.00 119.97 ? 422 LYS B C   1 
ATOM   4786 O O   . LYS B 1 422 ? 133.230 168.078 169.151 1.00 124.88 ? 422 LYS B O   1 
ATOM   4787 C CB  . LYS B 1 422 ? 131.174 167.267 170.950 1.00 126.63 ? 422 LYS B CB  1 
ATOM   4788 C CG  . LYS B 1 422 ? 131.632 167.990 172.204 1.00 128.79 ? 422 LYS B CG  1 
ATOM   4789 C CD  . LYS B 1 422 ? 131.750 167.032 173.376 1.00 130.52 ? 422 LYS B CD  1 
ATOM   4790 C CE  . LYS B 1 422 ? 132.151 167.760 174.646 1.00 127.99 ? 422 LYS B CE  1 
ATOM   4791 N NZ  . LYS B 1 422 ? 132.294 166.824 175.793 1.00 126.09 ? 422 LYS B NZ  1 
ATOM   4792 N N   . TRP B 1 423 ? 132.116 169.974 168.671 1.00 116.72 ? 423 TRP B N   1 
ATOM   4793 C CA  . TRP B 1 423 ? 133.251 170.601 168.006 1.00 116.93 ? 423 TRP B CA  1 
ATOM   4794 C C   . TRP B 1 423 ? 134.406 170.898 168.952 1.00 122.72 ? 423 TRP B C   1 
ATOM   4795 O O   . TRP B 1 423 ? 135.497 171.235 168.479 1.00 118.70 ? 423 TRP B O   1 
ATOM   4796 C CB  . TRP B 1 423 ? 132.805 171.894 167.321 1.00 112.93 ? 423 TRP B CB  1 
ATOM   4797 C CG  . TRP B 1 423 ? 131.897 171.677 166.150 1.00 106.44 ? 423 TRP B CG  1 
ATOM   4798 C CD1 . TRP B 1 423 ? 130.589 171.298 166.187 1.00 103.90 ? 423 TRP B CD1 1 
ATOM   4799 C CD2 . TRP B 1 423 ? 132.228 171.841 164.766 1.00 99.72  ? 423 TRP B CD2 1 
ATOM   4800 N NE1 . TRP B 1 423 ? 130.085 171.209 164.913 1.00 101.52 ? 423 TRP B NE1 1 
ATOM   4801 C CE2 . TRP B 1 423 ? 131.072 171.539 164.022 1.00 100.59 ? 423 TRP B CE2 1 
ATOM   4802 C CE3 . TRP B 1 423 ? 133.390 172.213 164.084 1.00 95.84  ? 423 TRP B CE3 1 
ATOM   4803 C CZ2 . TRP B 1 423 ? 131.043 171.596 162.631 1.00 99.77  ? 423 TRP B CZ2 1 
ATOM   4804 C CZ3 . TRP B 1 423 ? 133.359 172.269 162.703 1.00 96.31  ? 423 TRP B CZ3 1 
ATOM   4805 C CH2 . TRP B 1 423 ? 132.194 171.962 161.992 1.00 94.13  ? 423 TRP B CH2 1 
ATOM   4806 N N   . ASP B 1 424 ? 134.197 170.790 170.260 1.00 128.42 ? 424 ASP B N   1 
ATOM   4807 C CA  . ASP B 1 424 ? 135.239 171.065 171.239 1.00 132.36 ? 424 ASP B CA  1 
ATOM   4808 C C   . ASP B 1 424 ? 136.107 169.851 171.543 1.00 130.16 ? 424 ASP B C   1 
ATOM   4809 O O   . ASP B 1 424 ? 137.018 169.953 172.370 1.00 128.38 ? 424 ASP B O   1 
ATOM   4810 C CB  . ASP B 1 424 ? 134.614 171.592 172.534 1.00 136.34 ? 424 ASP B CB  1 
ATOM   4811 C CG  . ASP B 1 424 ? 133.863 172.894 172.329 1.00 137.06 ? 424 ASP B CG  1 
ATOM   4812 O OD1 . ASP B 1 424 ? 134.223 173.648 171.401 1.00 130.66 ? 424 ASP B OD1 1 
ATOM   4813 O OD2 . ASP B 1 424 ? 132.914 173.164 173.094 1.00 143.12 ? 424 ASP B OD2 1 
ATOM   4814 N N   . GLU B 1 425 ? 135.851 168.713 170.903 1.00 131.05 ? 425 GLU B N   1 
ATOM   4815 C CA  . GLU B 1 425 ? 136.661 167.515 171.067 1.00 130.35 ? 425 GLU B CA  1 
ATOM   4816 C C   . GLU B 1 425 ? 137.216 167.080 169.718 1.00 126.14 ? 425 GLU B C   1 
ATOM   4817 O O   . GLU B 1 425 ? 136.549 167.217 168.687 1.00 124.20 ? 425 GLU B O   1 
ATOM   4818 C CB  . GLU B 1 425 ? 135.854 166.371 171.692 1.00 130.82 ? 425 GLU B CB  1 
ATOM   4819 C CG  . GLU B 1 425 ? 135.442 166.615 173.134 1.00 132.08 ? 425 GLU B CG  1 
ATOM   4820 C CD  . GLU B 1 425 ? 134.907 165.365 173.804 1.00 135.81 ? 425 GLU B CD  1 
ATOM   4821 O OE1 . GLU B 1 425 ? 134.976 164.282 173.185 1.00 136.62 ? 425 GLU B OE1 1 
ATOM   4822 O OE2 . GLU B 1 425 ? 134.419 165.463 174.949 1.00 137.91 ? 425 GLU B OE2 1 
ATOM   4823 N N   . SER B 1 426 ? 138.439 166.553 169.732 1.00 124.15 ? 426 SER B N   1 
ATOM   4824 C CA  . SER B 1 426 ? 139.103 166.123 168.509 1.00 122.06 ? 426 SER B CA  1 
ATOM   4825 C C   . SER B 1 426 ? 138.582 164.793 167.980 1.00 122.40 ? 426 SER B C   1 
ATOM   4826 O O   . SER B 1 426 ? 138.920 164.423 166.851 1.00 118.47 ? 426 SER B O   1 
ATOM   4827 C CB  . SER B 1 426 ? 140.613 166.027 168.739 1.00 119.28 ? 426 SER B CB  1 
ATOM   4828 O OG  . SER B 1 426 ? 140.912 165.138 169.802 1.00 121.10 ? 426 SER B OG  1 
ATOM   4829 N N   . LYS B 1 427 ? 137.783 164.069 168.757 1.00 124.71 ? 427 LYS B N   1 
ATOM   4830 C CA  . LYS B 1 427 ? 137.232 162.804 168.299 1.00 125.51 ? 427 LYS B CA  1 
ATOM   4831 C C   . LYS B 1 427 ? 136.107 163.036 167.297 1.00 128.12 ? 427 LYS B C   1 
ATOM   4832 O O   . LYS B 1 427 ? 135.432 164.069 167.314 1.00 126.07 ? 427 LYS B O   1 
ATOM   4833 C CB  . LYS B 1 427 ? 136.718 161.981 169.480 1.00 130.27 ? 427 LYS B CB  1 
ATOM   4834 C CG  . LYS B 1 427 ? 137.817 161.439 170.377 1.00 130.21 ? 427 LYS B CG  1 
ATOM   4835 C CD  . LYS B 1 427 ? 138.744 160.516 169.606 1.00 127.75 ? 427 LYS B CD  1 
ATOM   4836 C CE  . LYS B 1 427 ? 139.864 159.994 170.489 1.00 125.55 ? 427 LYS B CE  1 
ATOM   4837 N NZ  . LYS B 1 427 ? 140.778 159.085 169.743 1.00 122.94 ? 427 LYS B NZ  1 
ATOM   4838 N N   . GLY B 1 428 ? 135.908 162.052 166.417 1.00 129.63 ? 428 GLY B N   1 
ATOM   4839 C CA  . GLY B 1 428 ? 134.879 162.158 165.398 1.00 122.76 ? 428 GLY B CA  1 
ATOM   4840 C C   . GLY B 1 428 ? 133.467 162.101 165.937 1.00 122.70 ? 428 GLY B C   1 
ATOM   4841 O O   . GLY B 1 428 ? 132.539 162.560 165.261 1.00 113.53 ? 428 GLY B O   1 
ATOM   4842 N N   . LEU B 1 429 ? 133.284 161.553 167.134 1.00 131.54 ? 429 LEU B N   1 
ATOM   4843 C CA  . LEU B 1 429 ? 131.973 161.470 167.764 1.00 133.70 ? 429 LEU B CA  1 
ATOM   4844 C C   . LEU B 1 429 ? 132.176 161.201 169.250 1.00 138.86 ? 429 LEU B C   1 
ATOM   4845 O O   . LEU B 1 429 ? 133.306 161.154 169.745 1.00 137.79 ? 429 LEU B O   1 
ATOM   4846 C CB  . LEU B 1 429 ? 131.106 160.386 167.119 1.00 129.36 ? 429 LEU B CB  1 
ATOM   4847 C CG  . LEU B 1 429 ? 131.503 158.931 167.375 1.00 129.64 ? 429 LEU B CG  1 
ATOM   4848 C CD1 . LEU B 1 429 ? 130.285 158.039 167.237 1.00 126.92 ? 429 LEU B CD1 1 
ATOM   4849 C CD2 . LEU B 1 429 ? 132.605 158.482 166.426 1.00 123.33 ? 429 LEU B CD2 1 
ATOM   4850 N N   . LEU B 1 430 ? 131.063 161.023 169.962 1.00 141.40 ? 430 LEU B N   1 
ATOM   4851 C CA  . LEU B 1 430 ? 131.102 160.744 171.386 1.00 145.12 ? 430 LEU B CA  1 
ATOM   4852 C C   . LEU B 1 430 ? 130.688 159.302 171.663 1.00 145.49 ? 430 LEU B C   1 
ATOM   4853 O O   . LEU B 1 430 ? 129.883 158.727 170.924 1.00 141.81 ? 430 LEU B O   1 
ATOM   4854 C CB  . LEU B 1 430 ? 130.179 161.693 172.161 1.00 144.20 ? 430 LEU B CB  1 
ATOM   4855 C CG  . LEU B 1 430 ? 130.465 163.189 172.005 1.00 141.51 ? 430 LEU B CG  1 
ATOM   4856 C CD1 . LEU B 1 430 ? 129.569 164.010 172.922 1.00 133.75 ? 430 LEU B CD1 1 
ATOM   4857 C CD2 . LEU B 1 430 ? 131.932 163.488 172.269 1.00 138.84 ? 430 LEU B CD2 1 
ATOM   4858 N N   . PRO B 1 431 ? 131.229 158.681 172.723 1.00 150.48 ? 431 PRO B N   1 
ATOM   4859 C CA  . PRO B 1 431 ? 130.855 157.311 173.093 1.00 148.72 ? 431 PRO B CA  1 
ATOM   4860 C C   . PRO B 1 431 ? 129.426 157.214 173.621 1.00 147.74 ? 431 PRO B C   1 
ATOM   4861 O O   . PRO B 1 431 ? 129.222 157.292 174.832 1.00 147.40 ? 431 PRO B O   1 
ATOM   4862 C CB  . PRO B 1 431 ? 131.866 156.954 174.187 1.00 149.46 ? 431 PRO B CB  1 
ATOM   4863 C CG  . PRO B 1 431 ? 132.291 158.265 174.753 1.00 148.92 ? 431 PRO B CG  1 
ATOM   4864 C CD  . PRO B 1 431 ? 132.286 159.219 173.598 1.00 149.40 ? 431 PRO B CD  1 
ATOM   4865 N N   . GLY B 1 446 ? 110.512 164.188 157.808 1.00 80.56  ? 446 GLY B N   1 
ATOM   4866 C CA  . GLY B 1 446 ? 109.940 165.222 156.966 1.00 81.42  ? 446 GLY B CA  1 
ATOM   4867 C C   . GLY B 1 446 ? 110.839 165.611 155.810 1.00 76.92  ? 446 GLY B C   1 
ATOM   4868 O O   . GLY B 1 446 ? 110.595 165.226 154.668 1.00 72.13  ? 446 GLY B O   1 
ATOM   4869 N N   . VAL B 1 447 ? 111.884 166.385 156.113 1.00 74.60  ? 447 VAL B N   1 
ATOM   4870 C CA  . VAL B 1 447 ? 112.839 166.779 155.083 1.00 72.06  ? 447 VAL B CA  1 
ATOM   4871 C C   . VAL B 1 447 ? 113.585 165.564 154.550 1.00 74.25  ? 447 VAL B C   1 
ATOM   4872 O O   . VAL B 1 447 ? 113.916 165.503 153.360 1.00 77.21  ? 447 VAL B O   1 
ATOM   4873 C CB  . VAL B 1 447 ? 113.806 167.843 155.633 1.00 74.30  ? 447 VAL B CB  1 
ATOM   4874 C CG1 . VAL B 1 447 ? 114.802 168.266 154.567 1.00 70.10  ? 447 VAL B CG1 1 
ATOM   4875 C CG2 . VAL B 1 447 ? 113.031 169.045 156.145 1.00 73.73  ? 447 VAL B CG2 1 
ATOM   4876 N N   . ARG B 1 448 ? 113.863 164.585 155.413 1.00 75.16  ? 448 ARG B N   1 
ATOM   4877 C CA  . ARG B 1 448 ? 114.549 163.373 154.979 1.00 73.26  ? 448 ARG B CA  1 
ATOM   4878 C C   . ARG B 1 448 ? 113.750 162.613 153.928 1.00 75.91  ? 448 ARG B C   1 
ATOM   4879 O O   . ARG B 1 448 ? 114.321 162.143 152.936 1.00 78.62  ? 448 ARG B O   1 
ATOM   4880 C CB  . ARG B 1 448 ? 114.835 162.489 156.192 1.00 78.25  ? 448 ARG B CB  1 
ATOM   4881 C CG  . ARG B 1 448 ? 115.131 161.040 155.870 1.00 89.33  ? 448 ARG B CG  1 
ATOM   4882 C CD  . ARG B 1 448 ? 115.818 160.356 157.041 1.00 97.64  ? 448 ARG B CD  1 
ATOM   4883 N NE  . ARG B 1 448 ? 117.171 160.862 157.235 1.00 104.99 ? 448 ARG B NE  1 
ATOM   4884 C CZ  . ARG B 1 448 ? 118.262 160.287 156.747 1.00 100.30 ? 448 ARG B CZ  1 
ATOM   4885 N NH1 . ARG B 1 448 ? 118.199 159.161 156.056 1.00 96.69  ? 448 ARG B NH1 1 
ATOM   4886 N NH2 . ARG B 1 448 ? 119.445 160.853 156.962 1.00 90.26  ? 448 ARG B NH2 1 
ATOM   4887 N N   . ALA B 1 449 ? 112.434 162.492 154.116 1.00 74.72  ? 449 ALA B N   1 
ATOM   4888 C CA  . ALA B 1 449 ? 111.602 161.827 153.118 1.00 69.50  ? 449 ALA B CA  1 
ATOM   4889 C C   . ALA B 1 449 ? 111.587 162.598 151.804 1.00 67.23  ? 449 ALA B C   1 
ATOM   4890 O O   . ALA B 1 449 ? 111.586 161.995 150.725 1.00 62.20  ? 449 ALA B O   1 
ATOM   4891 C CB  . ALA B 1 449 ? 110.183 161.649 153.654 1.00 68.10  ? 449 ALA B CB  1 
ATOM   4892 N N   . ILE B 1 450 ? 111.565 163.931 151.873 1.00 68.31  ? 450 ILE B N   1 
ATOM   4893 C CA  . ILE B 1 450 ? 111.600 164.739 150.658 1.00 63.47  ? 450 ILE B CA  1 
ATOM   4894 C C   . ILE B 1 450 ? 112.916 164.537 149.918 1.00 66.67  ? 450 ILE B C   1 
ATOM   4895 O O   . ILE B 1 450 ? 112.942 164.441 148.686 1.00 71.71  ? 450 ILE B O   1 
ATOM   4896 C CB  . ILE B 1 450 ? 111.360 166.220 150.996 1.00 62.65  ? 450 ILE B CB  1 
ATOM   4897 C CG1 . ILE B 1 450 ? 109.979 166.405 151.625 1.00 67.72  ? 450 ILE B CG1 1 
ATOM   4898 C CG2 . ILE B 1 450 ? 111.496 167.081 149.754 1.00 59.67  ? 450 ILE B CG2 1 
ATOM   4899 C CD1 . ILE B 1 450 ? 109.656 167.838 151.972 1.00 68.21  ? 450 ILE B CD1 1 
ATOM   4900 N N   . VAL B 1 451 ? 114.027 164.478 150.654 1.00 66.21  ? 451 VAL B N   1 
ATOM   4901 C CA  . VAL B 1 451 ? 115.321 164.205 150.033 1.00 64.77  ? 451 VAL B CA  1 
ATOM   4902 C C   . VAL B 1 451 ? 115.325 162.819 149.403 1.00 67.28  ? 451 VAL B C   1 
ATOM   4903 O O   . VAL B 1 451 ? 115.906 162.607 148.331 1.00 64.25  ? 451 VAL B O   1 
ATOM   4904 C CB  . VAL B 1 451 ? 116.453 164.364 151.066 1.00 62.09  ? 451 VAL B CB  1 
ATOM   4905 C CG1 . VAL B 1 451 ? 117.776 163.903 150.487 1.00 61.00  ? 451 VAL B CG1 1 
ATOM   4906 C CG2 . VAL B 1 451 ? 116.552 165.807 151.521 1.00 65.08  ? 451 VAL B CG2 1 
ATOM   4907 N N   . GLN B 1 452 ? 114.665 161.857 150.052 1.00 65.49  ? 452 GLN B N   1 
ATOM   4908 C CA  . GLN B 1 452 ? 114.629 160.495 149.530 1.00 59.11  ? 452 GLN B CA  1 
ATOM   4909 C C   . GLN B 1 452 ? 113.972 160.428 148.157 1.00 59.58  ? 452 GLN B C   1 
ATOM   4910 O O   . GLN B 1 452 ? 114.293 159.539 147.361 1.00 61.78  ? 452 GLN B O   1 
ATOM   4911 C CB  . GLN B 1 452 ? 113.896 159.583 150.514 1.00 62.74  ? 452 GLN B CB  1 
ATOM   4912 C CG  . GLN B 1 452 ? 113.908 158.114 150.140 1.00 67.79  ? 452 GLN B CG  1 
ATOM   4913 C CD  . GLN B 1 452 ? 115.299 157.521 150.153 1.00 69.60  ? 452 GLN B CD  1 
ATOM   4914 O OE1 . GLN B 1 452 ? 115.950 157.411 149.116 1.00 69.47  ? 452 GLN B OE1 1 
ATOM   4915 N NE2 . GLN B 1 452 ? 115.762 157.130 151.332 1.00 70.08  ? 452 GLN B NE2 1 
ATOM   4916 N N   . CYS B 1 453 ? 113.067 161.357 147.854 1.00 62.60  ? 453 CYS B N   1 
ATOM   4917 C CA  . CYS B 1 453 ? 112.307 161.332 146.612 1.00 59.60  ? 453 CYS B CA  1 
ATOM   4918 C C   . CYS B 1 453 ? 112.844 162.293 145.559 1.00 57.11  ? 453 CYS B C   1 
ATOM   4919 O O   . CYS B 1 453 ? 112.169 162.525 144.553 1.00 56.84  ? 453 CYS B O   1 
ATOM   4920 C CB  . CYS B 1 453 ? 110.837 161.644 146.889 1.00 55.41  ? 453 CYS B CB  1 
ATOM   4921 S SG  . CYS B 1 453 ? 110.052 160.534 148.068 1.00 66.60  ? 453 CYS B SG  1 
ATOM   4922 N N   . ILE B 1 454 ? 114.028 162.870 145.769 1.00 52.54  ? 454 ILE B N   1 
ATOM   4923 C CA  . ILE B 1 454 ? 114.584 163.794 144.779 1.00 52.70  ? 454 ILE B CA  1 
ATOM   4924 C C   . ILE B 1 454 ? 114.866 163.113 143.443 1.00 48.17  ? 454 ILE B C   1 
ATOM   4925 O O   . ILE B 1 454 ? 114.427 163.636 142.407 1.00 49.65  ? 454 ILE B O   1 
ATOM   4926 C CB  . ILE B 1 454 ? 115.820 164.508 145.356 1.00 57.87  ? 454 ILE B CB  1 
ATOM   4927 C CG1 . ILE B 1 454 ? 115.407 165.473 146.466 1.00 57.32  ? 454 ILE B CG1 1 
ATOM   4928 C CG2 . ILE B 1 454 ? 116.570 165.244 144.260 1.00 48.01  ? 454 ILE B CG2 1 
ATOM   4929 C CD1 . ILE B 1 454 ? 116.561 166.235 147.072 1.00 62.15  ? 454 ILE B CD1 1 
ATOM   4930 N N   . PRO B 1 455 ? 115.575 161.978 143.381 1.00 44.88  ? 455 PRO B N   1 
ATOM   4931 C CA  . PRO B 1 455 ? 115.798 161.361 142.063 1.00 41.93  ? 455 PRO B CA  1 
ATOM   4932 C C   . PRO B 1 455 ? 114.523 160.841 141.430 1.00 45.28  ? 455 PRO B C   1 
ATOM   4933 O O   . PRO B 1 455 ? 114.357 160.926 140.205 1.00 44.07  ? 455 PRO B O   1 
ATOM   4934 C CB  . PRO B 1 455 ? 116.784 160.227 142.368 1.00 39.80  ? 455 PRO B CB  1 
ATOM   4935 C CG  . PRO B 1 455 ? 117.341 160.530 143.707 1.00 45.68  ? 455 PRO B CG  1 
ATOM   4936 C CD  . PRO B 1 455 ? 116.249 161.213 144.443 1.00 50.40  ? 455 PRO B CD  1 
ATOM   4937 N N   . ALA B 1 456 ? 113.612 160.299 142.239 1.00 44.00  ? 456 ALA B N   1 
ATOM   4938 C CA  . ALA B 1 456 ? 112.331 159.853 141.710 1.00 39.47  ? 456 ALA B CA  1 
ATOM   4939 C C   . ALA B 1 456 ? 111.550 161.020 141.127 1.00 45.11  ? 456 ALA B C   1 
ATOM   4940 O O   . ALA B 1 456 ? 110.935 160.894 140.064 1.00 45.89  ? 456 ALA B O   1 
ATOM   4941 C CB  . ALA B 1 456 ? 111.526 159.154 142.803 1.00 42.14  ? 456 ALA B CB  1 
ATOM   4942 N N   . TRP B 1 457 ? 111.578 162.173 141.800 1.00 47.33  ? 457 TRP B N   1 
ATOM   4943 C CA  . TRP B 1 457 ? 110.899 163.351 141.270 1.00 41.70  ? 457 TRP B CA  1 
ATOM   4944 C C   . TRP B 1 457 ? 111.567 163.853 139.999 1.00 41.57  ? 457 TRP B C   1 
ATOM   4945 O O   . TRP B 1 457 ? 110.884 164.305 139.075 1.00 46.35  ? 457 TRP B O   1 
ATOM   4946 C CB  . TRP B 1 457 ? 110.848 164.457 142.320 1.00 42.85  ? 457 TRP B CB  1 
ATOM   4947 C CG  . TRP B 1 457 ? 110.050 165.643 141.875 1.00 55.06  ? 457 TRP B CG  1 
ATOM   4948 C CD1 . TRP B 1 457 ? 108.692 165.718 141.751 1.00 55.07  ? 457 TRP B CD1 1 
ATOM   4949 C CD2 . TRP B 1 457 ? 110.558 166.925 141.493 1.00 53.94  ? 457 TRP B CD2 1 
ATOM   4950 N NE1 . TRP B 1 457 ? 108.325 166.967 141.315 1.00 51.36  ? 457 TRP B NE1 1 
ATOM   4951 C CE2 . TRP B 1 457 ? 109.453 167.727 141.150 1.00 55.60  ? 457 TRP B CE2 1 
ATOM   4952 C CE3 . TRP B 1 457 ? 111.841 167.474 141.409 1.00 54.36  ? 457 TRP B CE3 1 
ATOM   4953 C CZ2 . TRP B 1 457 ? 109.591 169.047 140.729 1.00 62.36  ? 457 TRP B CZ2 1 
ATOM   4954 C CZ3 . TRP B 1 457 ? 111.976 168.784 140.993 1.00 62.15  ? 457 TRP B CZ3 1 
ATOM   4955 C CH2 . TRP B 1 457 ? 110.858 169.556 140.657 1.00 67.47  ? 457 TRP B CH2 1 
ATOM   4956 N N   . LEU B 1 458 ? 112.899 163.801 139.938 1.00 40.19  ? 458 LEU B N   1 
ATOM   4957 C CA  . LEU B 1 458 ? 113.593 164.217 138.723 1.00 42.62  ? 458 LEU B CA  1 
ATOM   4958 C C   . LEU B 1 458 ? 113.195 163.341 137.543 1.00 43.53  ? 458 LEU B C   1 
ATOM   4959 O O   . LEU B 1 458 ? 112.907 163.841 136.451 1.00 44.39  ? 458 LEU B O   1 
ATOM   4960 C CB  . LEU B 1 458 ? 115.105 164.179 138.941 1.00 43.42  ? 458 LEU B CB  1 
ATOM   4961 C CG  . LEU B 1 458 ? 115.682 165.204 139.920 1.00 51.85  ? 458 LEU B CG  1 
ATOM   4962 C CD1 . LEU B 1 458 ? 117.169 164.970 140.129 1.00 42.37  ? 458 LEU B CD1 1 
ATOM   4963 C CD2 . LEU B 1 458 ? 115.420 166.619 139.435 1.00 51.53  ? 458 LEU B CD2 1 
ATOM   4964 N N   . ARG B 1 459 ? 113.151 162.025 137.752 1.00 43.62  ? 459 ARG B N   1 
ATOM   4965 C CA  . ARG B 1 459 ? 112.726 161.129 136.680 1.00 35.70  ? 459 ARG B CA  1 
ATOM   4966 C C   . ARG B 1 459 ? 111.260 161.344 136.320 1.00 38.05  ? 459 ARG B C   1 
ATOM   4967 O O   . ARG B 1 459 ? 110.890 161.290 135.140 1.00 42.83  ? 459 ARG B O   1 
ATOM   4968 C CB  . ARG B 1 459 ? 112.985 159.680 137.079 1.00 32.52  ? 459 ARG B CB  1 
ATOM   4969 C CG  . ARG B 1 459 ? 114.365 159.196 136.696 1.00 30.50  ? 459 ARG B CG  1 
ATOM   4970 C CD  . ARG B 1 459 ? 114.566 159.335 135.200 1.00 36.87  ? 459 ARG B CD  1 
ATOM   4971 N NE  . ARG B 1 459 ? 113.748 158.394 134.447 1.00 40.71  ? 459 ARG B NE  1 
ATOM   4972 C CZ  . ARG B 1 459 ? 113.442 158.529 133.165 1.00 38.23  ? 459 ARG B CZ  1 
ATOM   4973 N NH1 . ARG B 1 459 ? 113.837 159.580 132.468 1.00 33.25  ? 459 ARG B NH1 1 
ATOM   4974 N NH2 . ARG B 1 459 ? 112.716 157.590 132.569 1.00 42.30  ? 459 ARG B NH2 1 
ATOM   4975 N N   . PHE B 1 460 ? 110.414 161.591 137.322 1.00 40.35  ? 460 PHE B N   1 
ATOM   4976 C CA  . PHE B 1 460 ? 108.996 161.836 137.076 1.00 37.64  ? 460 PHE B CA  1 
ATOM   4977 C C   . PHE B 1 460 ? 108.790 163.074 136.210 1.00 41.94  ? 460 PHE B C   1 
ATOM   4978 O O   . PHE B 1 460 ? 108.036 163.044 135.230 1.00 41.99  ? 460 PHE B O   1 
ATOM   4979 C CB  . PHE B 1 460 ? 108.270 161.970 138.415 1.00 39.27  ? 460 PHE B CB  1 
ATOM   4980 C CG  . PHE B 1 460 ? 106.819 162.326 138.298 1.00 45.86  ? 460 PHE B CG  1 
ATOM   4981 C CD1 . PHE B 1 460 ? 105.873 161.355 138.033 1.00 46.55  ? 460 PHE B CD1 1 
ATOM   4982 C CD2 . PHE B 1 460 ? 106.396 163.629 138.483 1.00 45.81  ? 460 PHE B CD2 1 
ATOM   4983 C CE1 . PHE B 1 460 ? 104.536 161.681 137.936 1.00 43.88  ? 460 PHE B CE1 1 
ATOM   4984 C CE2 . PHE B 1 460 ? 105.062 163.957 138.389 1.00 44.69  ? 460 PHE B CE2 1 
ATOM   4985 C CZ  . PHE B 1 460 ? 104.132 162.983 138.112 1.00 44.83  ? 460 PHE B CZ  1 
ATOM   4986 N N   . ILE B 1 461 ? 109.462 164.176 136.549 1.00 40.94  ? 461 ILE B N   1 
ATOM   4987 C CA  . ILE B 1 461 ? 109.300 165.385 135.749 1.00 41.85  ? 461 ILE B CA  1 
ATOM   4988 C C   . ILE B 1 461 ? 109.966 165.228 134.388 1.00 46.25  ? 461 ILE B C   1 
ATOM   4989 O O   . ILE B 1 461 ? 109.496 165.799 133.400 1.00 54.37  ? 461 ILE B O   1 
ATOM   4990 C CB  . ILE B 1 461 ? 109.818 166.628 136.496 1.00 42.07  ? 461 ILE B CB  1 
ATOM   4991 C CG1 . ILE B 1 461 ? 111.290 166.473 136.863 1.00 46.30  ? 461 ILE B CG1 1 
ATOM   4992 C CG2 . ILE B 1 461 ? 108.973 166.900 137.728 1.00 43.82  ? 461 ILE B CG2 1 
ATOM   4993 C CD1 . ILE B 1 461 ? 111.808 167.562 137.762 1.00 51.49  ? 461 ILE B CD1 1 
ATOM   4994 N N   . GLN B 1 462 ? 111.047 164.448 134.294 1.00 41.62  ? 462 GLN B N   1 
ATOM   4995 C CA  . GLN B 1 462 ? 111.651 164.195 132.989 1.00 40.97  ? 462 GLN B CA  1 
ATOM   4996 C C   . GLN B 1 462 ? 110.684 163.468 132.065 1.00 41.88  ? 462 GLN B C   1 
ATOM   4997 O O   . GLN B 1 462 ? 110.532 163.833 130.895 1.00 48.95  ? 462 GLN B O   1 
ATOM   4998 C CB  . GLN B 1 462 ? 112.937 163.385 133.144 1.00 38.34  ? 462 GLN B CB  1 
ATOM   4999 C CG  . GLN B 1 462 ? 114.142 164.197 133.536 1.00 38.85  ? 462 GLN B CG  1 
ATOM   5000 C CD  . GLN B 1 462 ? 115.429 163.442 133.333 1.00 38.50  ? 462 GLN B CD  1 
ATOM   5001 O OE1 . GLN B 1 462 ? 115.430 162.335 132.802 1.00 43.87  ? 462 GLN B OE1 1 
ATOM   5002 N NE2 . GLN B 1 462 ? 116.536 164.036 133.751 1.00 47.15  ? 462 GLN B NE2 1 
ATOM   5003 N N   . CYS B 1 463 ? 110.014 162.433 132.572 1.00 44.45  ? 463 CYS B N   1 
ATOM   5004 C CA  . CYS B 1 463 ? 109.104 161.693 131.706 1.00 48.38  ? 463 CYS B CA  1 
ATOM   5005 C C   . CYS B 1 463 ? 107.820 162.472 131.443 1.00 51.78  ? 463 CYS B C   1 
ATOM   5006 O O   . CYS B 1 463 ? 107.224 162.329 130.370 1.00 57.59  ? 463 CYS B O   1 
ATOM   5007 C CB  . CYS B 1 463 ? 108.804 160.315 132.291 1.00 48.81  ? 463 CYS B CB  1 
ATOM   5008 S SG  . CYS B 1 463 ? 108.200 160.320 133.969 1.00 65.68  ? 463 CYS B SG  1 
ATOM   5009 N N   . LEU B 1 464 ? 107.390 163.320 132.383 1.00 51.47  ? 464 LEU B N   1 
ATOM   5010 C CA  . LEU B 1 464 ? 106.289 164.231 132.083 1.00 50.24  ? 464 LEU B CA  1 
ATOM   5011 C C   . LEU B 1 464 ? 106.668 165.205 130.974 1.00 54.84  ? 464 LEU B C   1 
ATOM   5012 O O   . LEU B 1 464 ? 105.859 165.494 130.086 1.00 61.55  ? 464 LEU B O   1 
ATOM   5013 C CB  . LEU B 1 464 ? 105.868 164.992 133.338 1.00 43.89  ? 464 LEU B CB  1 
ATOM   5014 C CG  . LEU B 1 464 ? 104.961 164.253 134.319 1.00 46.25  ? 464 LEU B CG  1 
ATOM   5015 C CD1 . LEU B 1 464 ? 104.325 165.242 135.276 1.00 42.84  ? 464 LEU B CD1 1 
ATOM   5016 C CD2 . LEU B 1 464 ? 103.897 163.457 133.583 1.00 55.15  ? 464 LEU B CD2 1 
ATOM   5017 N N   . ARG B 1 465 ? 107.899 165.721 131.011 1.00 53.83  ? 465 ARG B N   1 
ATOM   5018 C CA  . ARG B 1 465 ? 108.379 166.595 129.948 1.00 56.54  ? 465 ARG B CA  1 
ATOM   5019 C C   . ARG B 1 465 ? 108.433 165.859 128.616 1.00 60.79  ? 465 ARG B C   1 
ATOM   5020 O O   . ARG B 1 465 ? 108.093 166.423 127.571 1.00 66.99  ? 465 ARG B O   1 
ATOM   5021 C CB  . ARG B 1 465 ? 109.757 167.141 130.320 1.00 57.41  ? 465 ARG B CB  1 
ATOM   5022 C CG  . ARG B 1 465 ? 109.982 168.601 129.980 1.00 67.96  ? 465 ARG B CG  1 
ATOM   5023 C CD  . ARG B 1 465 ? 110.298 168.802 128.511 1.00 71.23  ? 465 ARG B CD  1 
ATOM   5024 N NE  . ARG B 1 465 ? 110.714 170.173 128.244 1.00 70.29  ? 465 ARG B NE  1 
ATOM   5025 C CZ  . ARG B 1 465 ? 111.168 170.606 127.077 1.00 75.13  ? 465 ARG B CZ  1 
ATOM   5026 N NH1 . ARG B 1 465 ? 111.280 169.797 126.036 1.00 76.35  ? 465 ARG B NH1 1 
ATOM   5027 N NH2 . ARG B 1 465 ? 111.521 171.881 126.951 1.00 72.27  ? 465 ARG B NH2 1 
ATOM   5028 N N   . ARG B 1 466 ? 108.871 164.600 128.634 1.00 58.83  ? 466 ARG B N   1 
ATOM   5029 C CA  . ARG B 1 466 ? 108.915 163.814 127.404 1.00 58.82  ? 466 ARG B CA  1 
ATOM   5030 C C   . ARG B 1 466 ? 107.517 163.577 126.847 1.00 63.99  ? 466 ARG B C   1 
ATOM   5031 O O   . ARG B 1 466 ? 107.312 163.628 125.629 1.00 68.83  ? 466 ARG B O   1 
ATOM   5032 C CB  . ARG B 1 466 ? 109.633 162.489 127.651 1.00 53.79  ? 466 ARG B CB  1 
ATOM   5033 C CG  . ARG B 1 466 ? 111.132 162.632 127.803 1.00 49.50  ? 466 ARG B CG  1 
ATOM   5034 C CD  . ARG B 1 466 ? 111.809 161.290 128.001 1.00 49.91  ? 466 ARG B CD  1 
ATOM   5035 N NE  . ARG B 1 466 ? 111.451 160.325 126.969 1.00 53.89  ? 466 ARG B NE  1 
ATOM   5036 C CZ  . ARG B 1 466 ? 111.950 160.319 125.741 1.00 56.95  ? 466 ARG B CZ  1 
ATOM   5037 N NH1 . ARG B 1 466 ? 112.803 161.244 125.336 1.00 60.06  ? 466 ARG B NH1 1 
ATOM   5038 N NH2 . ARG B 1 466 ? 111.580 159.362 124.896 1.00 56.93  ? 466 ARG B NH2 1 
ATOM   5039 N N   . TYR B 1 467 ? 106.545 163.302 127.719 1.00 65.99  ? 467 TYR B N   1 
ATOM   5040 C CA  . TYR B 1 467 ? 105.164 163.168 127.263 1.00 71.95  ? 467 TYR B CA  1 
ATOM   5041 C C   . TYR B 1 467 ? 104.646 164.476 126.681 1.00 75.52  ? 467 TYR B C   1 
ATOM   5042 O O   . TYR B 1 467 ? 103.960 164.480 125.654 1.00 80.36  ? 467 TYR B O   1 
ATOM   5043 C CB  . TYR B 1 467 ? 104.265 162.710 128.409 1.00 72.45  ? 467 TYR B CB  1 
ATOM   5044 C CG  . TYR B 1 467 ? 102.804 163.010 128.170 1.00 75.64  ? 467 TYR B CG  1 
ATOM   5045 C CD1 . TYR B 1 467 ? 102.091 162.343 127.186 1.00 74.13  ? 467 TYR B CD1 1 
ATOM   5046 C CD2 . TYR B 1 467 ? 102.139 163.965 128.926 1.00 76.95  ? 467 TYR B CD2 1 
ATOM   5047 C CE1 . TYR B 1 467 ? 100.758 162.616 126.961 1.00 74.01  ? 467 TYR B CE1 1 
ATOM   5048 C CE2 . TYR B 1 467 ? 100.805 164.245 128.709 1.00 76.36  ? 467 TYR B CE2 1 
ATOM   5049 C CZ  . TYR B 1 467 ? 100.120 163.567 127.725 1.00 76.43  ? 467 TYR B CZ  1 
ATOM   5050 O OH  . TYR B 1 467 ? 98.791  163.839 127.503 1.00 85.84  ? 467 TYR B OH  1 
ATOM   5051 N N   . ARG B 1 468 ? 104.957 165.597 127.333 1.00 71.84  ? 468 ARG B N   1 
ATOM   5052 C CA  . ARG B 1 468 ? 104.545 166.900 126.823 1.00 72.57  ? 468 ARG B CA  1 
ATOM   5053 C C   . ARG B 1 468 ? 105.149 167.167 125.451 1.00 79.03  ? 468 ARG B C   1 
ATOM   5054 O O   . ARG B 1 468 ? 104.489 167.730 124.570 1.00 83.90  ? 468 ARG B O   1 
ATOM   5055 C CB  . ARG B 1 468 ? 104.954 167.988 127.814 1.00 70.50  ? 468 ARG B CB  1 
ATOM   5056 C CG  . ARG B 1 468 ? 104.633 169.407 127.392 1.00 74.57  ? 468 ARG B CG  1 
ATOM   5057 C CD  . ARG B 1 468 ? 105.397 170.394 128.261 1.00 79.36  ? 468 ARG B CD  1 
ATOM   5058 N NE  . ARG B 1 468 ? 105.369 170.010 129.668 1.00 81.07  ? 468 ARG B NE  1 
ATOM   5059 C CZ  . ARG B 1 468 ? 106.112 170.568 130.615 1.00 79.51  ? 468 ARG B CZ  1 
ATOM   5060 N NH1 . ARG B 1 468 ? 106.961 171.545 130.342 1.00 74.27  ? 468 ARG B NH1 1 
ATOM   5061 N NH2 . ARG B 1 468 ? 106.004 170.131 131.866 1.00 71.81  ? 468 ARG B NH2 1 
ATOM   5062 N N   . ASP B 1 469 ? 106.406 166.769 125.253 1.00 75.97  ? 469 ASP B N   1 
ATOM   5063 C CA  . ASP B 1 469 ? 107.088 167.043 123.994 1.00 77.68  ? 469 ASP B CA  1 
ATOM   5064 C C   . ASP B 1 469 ? 106.606 166.119 122.879 1.00 79.71  ? 469 ASP B C   1 
ATOM   5065 O O   . ASP B 1 469 ? 106.479 166.546 121.726 1.00 80.48  ? 469 ASP B O   1 
ATOM   5066 C CB  . ASP B 1 469 ? 108.599 166.911 124.191 1.00 83.20  ? 469 ASP B CB  1 
ATOM   5067 C CG  . ASP B 1 469 ? 109.392 167.461 123.025 1.00 89.79  ? 469 ASP B CG  1 
ATOM   5068 O OD1 . ASP B 1 469 ? 109.369 168.692 122.817 1.00 89.59  ? 469 ASP B OD1 1 
ATOM   5069 O OD2 . ASP B 1 469 ? 110.046 166.664 122.321 1.00 87.52  ? 469 ASP B OD2 1 
ATOM   5070 N N   . THR B 1 470 ? 106.328 164.855 123.200 1.00 79.02  ? 470 THR B N   1 
ATOM   5071 C CA  . THR B 1 470 ? 105.997 163.855 122.193 1.00 79.70  ? 470 THR B CA  1 
ATOM   5072 C C   . THR B 1 470 ? 104.507 163.557 122.091 1.00 81.84  ? 470 THR B C   1 
ATOM   5073 O O   . THR B 1 470 ? 104.085 162.951 121.101 1.00 86.22  ? 470 THR B O   1 
ATOM   5074 C CB  . THR B 1 470 ? 106.747 162.548 122.478 1.00 83.13  ? 470 THR B CB  1 
ATOM   5075 O OG1 . THR B 1 470 ? 106.342 162.035 123.752 1.00 84.76  ? 470 THR B OG1 1 
ATOM   5076 C CG2 . THR B 1 470 ? 108.246 162.787 122.489 1.00 84.91  ? 470 THR B CG2 1 
ATOM   5077 N N   . LYS B 1 471 ? 103.710 163.959 123.083 1.00 82.30  ? 471 LYS B N   1 
ATOM   5078 C CA  . LYS B 1 471 ? 102.262 163.738 123.078 1.00 85.57  ? 471 LYS B CA  1 
ATOM   5079 C C   . LYS B 1 471 ? 101.915 162.256 122.948 1.00 87.58  ? 471 LYS B C   1 
ATOM   5080 O O   . LYS B 1 471 ? 100.993 161.878 122.223 1.00 89.46  ? 471 LYS B O   1 
ATOM   5081 C CB  . LYS B 1 471 ? 101.582 164.552 121.975 1.00 84.65  ? 471 LYS B CB  1 
ATOM   5082 C CG  . LYS B 1 471 ? 101.806 166.050 122.079 1.00 87.20  ? 471 LYS B CG  1 
ATOM   5083 C CD  . LYS B 1 471 ? 101.257 166.599 123.384 1.00 90.63  ? 471 LYS B CD  1 
ATOM   5084 C CE  . LYS B 1 471 ? 101.451 168.102 123.476 1.00 92.25  ? 471 LYS B CE  1 
ATOM   5085 N NZ  . LYS B 1 471 ? 100.944 168.645 124.766 1.00 91.60  ? 471 LYS B NZ  1 
ATOM   5086 N N   . ARG B 1 472 ? 102.661 161.407 123.653 1.00 87.93  ? 472 ARG B N   1 
ATOM   5087 C CA  . ARG B 1 472 ? 102.403 159.969 123.679 1.00 83.54  ? 472 ARG B CA  1 
ATOM   5088 C C   . ARG B 1 472 ? 102.204 159.538 125.125 1.00 79.91  ? 472 ARG B C   1 
ATOM   5089 O O   . ARG B 1 472 ? 103.123 159.651 125.942 1.00 74.55  ? 472 ARG B O   1 
ATOM   5090 C CB  . ARG B 1 472 ? 103.544 159.186 123.030 1.00 79.35  ? 472 ARG B CB  1 
ATOM   5091 C CG  . ARG B 1 472 ? 103.685 159.420 121.537 1.00 87.03  ? 472 ARG B CG  1 
ATOM   5092 C CD  . ARG B 1 472 ? 104.576 158.368 120.899 1.00 90.70  ? 472 ARG B CD  1 
ATOM   5093 N NE  . ARG B 1 472 ? 105.914 158.359 121.477 1.00 97.30  ? 472 ARG B NE  1 
ATOM   5094 C CZ  . ARG B 1 472 ? 106.950 159.021 120.980 1.00 99.53  ? 472 ARG B CZ  1 
ATOM   5095 N NH1 . ARG B 1 472 ? 106.839 159.756 119.886 1.00 96.81  ? 472 ARG B NH1 1 
ATOM   5096 N NH2 . ARG B 1 472 ? 108.126 158.943 121.596 1.00 91.34  ? 472 ARG B NH2 1 
ATOM   5097 N N   . ALA B 1 473 ? 101.004 159.043 125.438 1.00 78.25  ? 473 ALA B N   1 
ATOM   5098 C CA  . ALA B 1 473 ? 100.719 158.590 126.795 1.00 75.49  ? 473 ALA B CA  1 
ATOM   5099 C C   . ALA B 1 473 ? 101.596 157.406 127.178 1.00 74.70  ? 473 ALA B C   1 
ATOM   5100 O O   . ALA B 1 473 ? 102.098 157.333 128.305 1.00 70.33  ? 473 ALA B O   1 
ATOM   5101 C CB  . ALA B 1 473 ? 99.241  158.229 126.929 1.00 75.33  ? 473 ALA B CB  1 
ATOM   5102 N N   . PHE B 1 474 ? 101.789 156.469 126.258 1.00 72.31  ? 474 PHE B N   1 
ATOM   5103 C CA  . PHE B 1 474 ? 102.656 155.326 126.506 1.00 70.46  ? 474 PHE B CA  1 
ATOM   5104 C C   . PHE B 1 474 ? 103.983 155.524 125.794 1.00 68.98  ? 474 PHE B C   1 
ATOM   5105 O O   . PHE B 1 474 ? 103.992 155.946 124.628 1.00 74.29  ? 474 PHE B O   1 
ATOM   5106 C CB  . PHE B 1 474 ? 101.995 154.036 126.025 1.00 67.69  ? 474 PHE B CB  1 
ATOM   5107 C CG  . PHE B 1 474 ? 102.800 152.799 126.309 1.00 66.34  ? 474 PHE B CG  1 
ATOM   5108 C CD1 . PHE B 1 474 ? 102.740 152.188 127.549 1.00 65.01  ? 474 PHE B CD1 1 
ATOM   5109 C CD2 . PHE B 1 474 ? 103.613 152.245 125.335 1.00 64.10  ? 474 PHE B CD2 1 
ATOM   5110 C CE1 . PHE B 1 474 ? 103.480 151.053 127.815 1.00 63.36  ? 474 PHE B CE1 1 
ATOM   5111 C CE2 . PHE B 1 474 ? 104.354 151.110 125.595 1.00 66.25  ? 474 PHE B CE2 1 
ATOM   5112 C CZ  . PHE B 1 474 ? 104.287 150.514 126.836 1.00 66.35  ? 474 PHE B CZ  1 
ATOM   5113 N N   . PRO B 1 475 ? 105.118 155.229 126.436 1.00 61.61  ? 475 PRO B N   1 
ATOM   5114 C CA  . PRO B 1 475 ? 105.277 154.732 127.807 1.00 62.24  ? 475 PRO B CA  1 
ATOM   5115 C C   . PRO B 1 475 ? 105.571 155.815 128.841 1.00 60.48  ? 475 PRO B C   1 
ATOM   5116 O O   . PRO B 1 475 ? 105.933 155.495 129.969 1.00 59.99  ? 475 PRO B O   1 
ATOM   5117 C CB  . PRO B 1 475 ? 106.462 153.774 127.662 1.00 61.98  ? 475 PRO B CB  1 
ATOM   5118 C CG  . PRO B 1 475 ? 107.335 154.461 126.649 1.00 51.00  ? 475 PRO B CG  1 
ATOM   5119 C CD  . PRO B 1 475 ? 106.387 155.152 125.689 1.00 55.00  ? 475 PRO B CD  1 
ATOM   5120 N N   . HIS B 1 476 ? 105.420 157.097 128.503 1.00 60.65  ? 476 HIS B N   1 
ATOM   5121 C CA  . HIS B 1 476 ? 105.913 158.155 129.382 1.00 58.89  ? 476 HIS B CA  1 
ATOM   5122 C C   . HIS B 1 476 ? 105.058 158.304 130.636 1.00 57.09  ? 476 HIS B C   1 
ATOM   5123 O O   . HIS B 1 476 ? 105.594 158.429 131.743 1.00 54.61  ? 476 HIS B O   1 
ATOM   5124 C CB  . HIS B 1 476 ? 105.987 159.471 128.614 1.00 56.56  ? 476 HIS B CB  1 
ATOM   5125 C CG  . HIS B 1 476 ? 106.801 159.387 127.363 1.00 59.74  ? 476 HIS B CG  1 
ATOM   5126 N ND1 . HIS B 1 476 ? 106.234 159.285 126.111 1.00 71.56  ? 476 HIS B ND1 1 
ATOM   5127 C CD2 . HIS B 1 476 ? 108.141 159.370 127.171 1.00 55.19  ? 476 HIS B CD2 1 
ATOM   5128 C CE1 . HIS B 1 476 ? 107.189 159.220 125.201 1.00 70.32  ? 476 HIS B CE1 1 
ATOM   5129 N NE2 . HIS B 1 476 ? 108.356 159.268 125.818 1.00 57.48  ? 476 HIS B NE2 1 
ATOM   5130 N N   . LEU B 1 477 ? 103.732 158.293 130.496 1.00 59.38  ? 477 LEU B N   1 
ATOM   5131 C CA  . LEU B 1 477 ? 102.881 158.392 131.677 1.00 57.39  ? 477 LEU B CA  1 
ATOM   5132 C C   . LEU B 1 477 ? 102.958 157.134 132.533 1.00 57.45  ? 477 LEU B C   1 
ATOM   5133 O O   . LEU B 1 477 ? 102.863 157.213 133.764 1.00 59.75  ? 477 LEU B O   1 
ATOM   5134 C CB  . LEU B 1 477 ? 101.440 158.677 131.262 1.00 63.54  ? 477 LEU B CB  1 
ATOM   5135 C CG  . LEU B 1 477 ? 101.240 160.011 130.543 1.00 71.54  ? 477 LEU B CG  1 
ATOM   5136 C CD1 . LEU B 1 477 ? 99.772  160.244 130.239 1.00 74.73  ? 477 LEU B CD1 1 
ATOM   5137 C CD2 . LEU B 1 477 ? 101.808 161.152 131.371 1.00 66.01  ? 477 LEU B CD2 1 
ATOM   5138 N N   . VAL B 1 478 ? 103.138 155.971 131.906 1.00 53.37  ? 478 VAL B N   1 
ATOM   5139 C CA  . VAL B 1 478 ? 103.346 154.742 132.665 1.00 51.03  ? 478 VAL B CA  1 
ATOM   5140 C C   . VAL B 1 478 ? 104.638 154.829 133.469 1.00 56.76  ? 478 VAL B C   1 
ATOM   5141 O O   . VAL B 1 478 ? 104.690 154.426 134.638 1.00 60.17  ? 478 VAL B O   1 
ATOM   5142 C CB  . VAL B 1 478 ? 103.337 153.528 131.717 1.00 51.76  ? 478 VAL B CB  1 
ATOM   5143 C CG1 . VAL B 1 478 ? 103.216 152.239 132.504 1.00 51.34  ? 478 VAL B CG1 1 
ATOM   5144 C CG2 . VAL B 1 478 ? 102.199 153.651 130.723 1.00 51.76  ? 478 VAL B CG2 1 
ATOM   5145 N N   . ASN B 1 479 ? 105.697 155.367 132.860 1.00 52.13  ? 479 ASN B N   1 
ATOM   5146 C CA  . ASN B 1 479 ? 106.945 155.590 133.585 1.00 47.51  ? 479 ASN B CA  1 
ATOM   5147 C C   . ASN B 1 479 ? 106.752 156.582 134.728 1.00 53.34  ? 479 ASN B C   1 
ATOM   5148 O O   . ASN B 1 479 ? 107.325 156.417 135.813 1.00 53.59  ? 479 ASN B O   1 
ATOM   5149 C CB  . ASN B 1 479 ? 108.017 156.085 132.616 1.00 44.54  ? 479 ASN B CB  1 
ATOM   5150 C CG  . ASN B 1 479 ? 109.275 155.251 132.665 1.00 52.88  ? 479 ASN B CG  1 
ATOM   5151 O OD1 . ASN B 1 479 ? 109.373 154.303 133.438 1.00 58.73  ? 479 ASN B OD1 1 
ATOM   5152 N ND2 . ASN B 1 479 ? 110.244 155.593 131.828 1.00 56.08  ? 479 ASN B ND2 1 
ATOM   5153 N N   . ALA B 1 480 ? 105.956 157.627 134.496 1.00 53.23  ? 480 ALA B N   1 
ATOM   5154 C CA  . ALA B 1 480 ? 105.672 158.593 135.552 1.00 48.00  ? 480 ALA B CA  1 
ATOM   5155 C C   . ALA B 1 480 ? 104.974 157.932 136.731 1.00 51.23  ? 480 ALA B C   1 
ATOM   5156 O O   . ALA B 1 480 ? 105.308 158.198 137.891 1.00 49.51  ? 480 ALA B O   1 
ATOM   5157 C CB  . ALA B 1 480 ? 104.827 159.738 134.998 1.00 49.03  ? 480 ALA B CB  1 
ATOM   5158 N N   . GLY B 1 481 ? 103.998 157.067 136.453 1.00 43.96  ? 481 GLY B N   1 
ATOM   5159 C CA  . GLY B 1 481 ? 103.369 156.313 137.526 1.00 43.14  ? 481 GLY B CA  1 
ATOM   5160 C C   . GLY B 1 481 ? 104.346 155.397 138.239 1.00 47.07  ? 481 GLY B C   1 
ATOM   5161 O O   . GLY B 1 481 ? 104.300 155.250 139.466 1.00 51.31  ? 481 GLY B O   1 
ATOM   5162 N N   . LYS B 1 482 ? 105.250 154.774 137.477 1.00 43.68  ? 482 LYS B N   1 
ATOM   5163 C CA  . LYS B 1 482 ? 106.267 153.918 138.077 1.00 44.72  ? 482 LYS B CA  1 
ATOM   5164 C C   . LYS B 1 482 ? 107.118 154.691 139.070 1.00 47.82  ? 482 LYS B C   1 
ATOM   5165 O O   . LYS B 1 482 ? 107.430 154.191 140.156 1.00 52.39  ? 482 LYS B O   1 
ATOM   5166 C CB  . LYS B 1 482 ? 107.153 153.311 136.993 1.00 42.70  ? 482 LYS B CB  1 
ATOM   5167 C CG  . LYS B 1 482 ? 108.306 152.497 137.542 1.00 39.34  ? 482 LYS B CG  1 
ATOM   5168 C CD  . LYS B 1 482 ? 109.214 152.017 136.434 1.00 45.22  ? 482 LYS B CD  1 
ATOM   5169 C CE  . LYS B 1 482 ? 110.339 152.993 136.174 1.00 45.52  ? 482 LYS B CE  1 
ATOM   5170 N NZ  . LYS B 1 482 ? 111.296 153.010 137.305 1.00 50.22  ? 482 LYS B NZ  1 
ATOM   5171 N N   . TYR B 1 483 ? 107.513 155.910 138.710 1.00 50.09  ? 483 TYR B N   1 
ATOM   5172 C CA  . TYR B 1 483 ? 108.331 156.707 139.617 1.00 43.92  ? 483 TYR B CA  1 
ATOM   5173 C C   . TYR B 1 483 ? 107.520 157.292 140.767 1.00 46.92  ? 483 TYR B C   1 
ATOM   5174 O O   . TYR B 1 483 ? 108.068 157.505 141.853 1.00 50.23  ? 483 TYR B O   1 
ATOM   5175 C CB  . TYR B 1 483 ? 109.053 157.809 138.845 1.00 36.87  ? 483 TYR B CB  1 
ATOM   5176 C CG  . TYR B 1 483 ? 110.165 157.273 137.981 1.00 34.78  ? 483 TYR B CG  1 
ATOM   5177 C CD1 . TYR B 1 483 ? 111.307 156.732 138.550 1.00 36.94  ? 483 TYR B CD1 1 
ATOM   5178 C CD2 . TYR B 1 483 ? 110.071 157.291 136.600 1.00 38.29  ? 483 TYR B CD2 1 
ATOM   5179 C CE1 . TYR B 1 483 ? 112.323 156.230 137.767 1.00 42.24  ? 483 TYR B CE1 1 
ATOM   5180 C CE2 . TYR B 1 483 ? 111.081 156.792 135.810 1.00 37.81  ? 483 TYR B CE2 1 
ATOM   5181 C CZ  . TYR B 1 483 ? 112.205 156.264 136.398 1.00 42.45  ? 483 TYR B CZ  1 
ATOM   5182 O OH  . TYR B 1 483 ? 113.217 155.768 135.616 1.00 45.00  ? 483 TYR B OH  1 
ATOM   5183 N N   . SER B 1 484 ? 106.226 157.551 140.561 1.00 48.45  ? 484 SER B N   1 
ATOM   5184 C CA  . SER B 1 484 ? 105.383 158.048 141.644 1.00 47.88  ? 484 SER B CA  1 
ATOM   5185 C C   . SER B 1 484 ? 105.054 156.968 142.664 1.00 51.23  ? 484 SER B C   1 
ATOM   5186 O O   . SER B 1 484 ? 104.675 157.293 143.799 1.00 55.60  ? 484 SER B O   1 
ATOM   5187 C CB  . SER B 1 484 ? 104.091 158.635 141.080 1.00 50.45  ? 484 SER B CB  1 
ATOM   5188 O OG  . SER B 1 484 ? 103.308 157.631 140.463 1.00 54.15  ? 484 SER B OG  1 
ATOM   5189 N N   . THR B 1 485 ? 105.160 155.694 142.279 1.00 51.45  ? 485 THR B N   1 
ATOM   5190 C CA  . THR B 1 485 ? 105.057 154.632 143.275 1.00 51.95  ? 485 THR B CA  1 
ATOM   5191 C C   . THR B 1 485 ? 106.083 154.819 144.385 1.00 55.16  ? 485 THR B C   1 
ATOM   5192 O O   . THR B 1 485 ? 105.812 154.491 145.546 1.00 57.08  ? 485 THR B O   1 
ATOM   5193 C CB  . THR B 1 485 ? 105.228 153.260 142.621 1.00 47.74  ? 485 THR B CB  1 
ATOM   5194 O OG1 . THR B 1 485 ? 106.451 153.228 141.879 1.00 51.82  ? 485 THR B OG1 1 
ATOM   5195 C CG2 . THR B 1 485 ? 104.068 152.965 141.692 1.00 45.67  ? 485 THR B CG2 1 
ATOM   5196 N N   . THR B 1 486 ? 107.258 155.361 144.052 1.00 54.26  ? 486 THR B N   1 
ATOM   5197 C CA  . THR B 1 486 ? 108.249 155.677 145.075 1.00 55.11  ? 486 THR B CA  1 
ATOM   5198 C C   . THR B 1 486 ? 107.747 156.764 146.017 1.00 59.05  ? 486 THR B C   1 
ATOM   5199 O O   . THR B 1 486 ? 107.949 156.676 147.234 1.00 59.99  ? 486 THR B O   1 
ATOM   5200 C CB  . THR B 1 486 ? 109.566 156.098 144.423 1.00 52.64  ? 486 THR B CB  1 
ATOM   5201 O OG1 . THR B 1 486 ? 110.013 155.067 143.534 1.00 57.51  ? 486 THR B OG1 1 
ATOM   5202 C CG2 . THR B 1 486 ? 110.630 156.339 145.481 1.00 54.26  ? 486 THR B CG2 1 
ATOM   5203 N N   . PHE B 1 487 ? 107.090 157.798 145.479 1.00 59.18  ? 487 PHE B N   1 
ATOM   5204 C CA  . PHE B 1 487 ? 106.511 158.830 146.336 1.00 56.96  ? 487 PHE B CA  1 
ATOM   5205 C C   . PHE B 1 487 ? 105.507 158.222 147.299 1.00 60.59  ? 487 PHE B C   1 
ATOM   5206 O O   . PHE B 1 487 ? 105.508 158.530 148.496 1.00 63.33  ? 487 PHE B O   1 
ATOM   5207 C CB  . PHE B 1 487 ? 105.815 159.908 145.504 1.00 49.02  ? 487 PHE B CB  1 
ATOM   5208 C CG  . PHE B 1 487 ? 106.673 160.528 144.451 1.00 50.44  ? 487 PHE B CG  1 
ATOM   5209 C CD1 . PHE B 1 487 ? 108.039 160.628 144.609 1.00 51.29  ? 487 PHE B CD1 1 
ATOM   5210 C CD2 . PHE B 1 487 ? 106.099 161.026 143.297 1.00 55.64  ? 487 PHE B CD2 1 
ATOM   5211 C CE1 . PHE B 1 487 ? 108.812 161.203 143.631 1.00 54.53  ? 487 PHE B CE1 1 
ATOM   5212 C CE2 . PHE B 1 487 ? 106.868 161.598 142.317 1.00 51.39  ? 487 PHE B CE2 1 
ATOM   5213 C CZ  . PHE B 1 487 ? 108.223 161.686 142.483 1.00 47.47  ? 487 PHE B CZ  1 
ATOM   5214 N N   . PHE B 1 488 ? 104.626 157.366 146.781 1.00 60.27  ? 488 PHE B N   1 
ATOM   5215 C CA  . PHE B 1 488 ? 103.605 156.759 147.630 1.00 59.19  ? 488 PHE B CA  1 
ATOM   5216 C C   . PHE B 1 488 ? 104.232 155.892 148.714 1.00 65.01  ? 488 PHE B C   1 
ATOM   5217 O O   . PHE B 1 488 ? 103.844 155.973 149.888 1.00 72.59  ? 488 PHE B O   1 
ATOM   5218 C CB  . PHE B 1 488 ? 102.630 155.944 146.784 1.00 55.44  ? 488 PHE B CB  1 
ATOM   5219 C CG  . PHE B 1 488 ? 101.626 156.781 146.051 1.00 62.22  ? 488 PHE B CG  1 
ATOM   5220 C CD1 . PHE B 1 488 ? 100.577 157.374 146.729 1.00 64.09  ? 488 PHE B CD1 1 
ATOM   5221 C CD2 . PHE B 1 488 ? 101.729 156.976 144.686 1.00 63.60  ? 488 PHE B CD2 1 
ATOM   5222 C CE1 . PHE B 1 488 ? 99.652  158.147 146.062 1.00 68.08  ? 488 PHE B CE1 1 
ATOM   5223 C CE2 . PHE B 1 488 ? 100.807 157.748 144.011 1.00 65.52  ? 488 PHE B CE2 1 
ATOM   5224 C CZ  . PHE B 1 488 ? 99.767  158.334 144.701 1.00 74.94  ? 488 PHE B CZ  1 
ATOM   5225 N N   . MET B 1 489 ? 105.219 155.074 148.347 1.00 60.54  ? 489 MET B N   1 
ATOM   5226 C CA  . MET B 1 489 ? 105.882 154.226 149.330 1.00 63.99  ? 489 MET B CA  1 
ATOM   5227 C C   . MET B 1 489 ? 106.566 155.061 150.407 1.00 72.99  ? 489 MET B C   1 
ATOM   5228 O O   . MET B 1 489 ? 106.466 154.758 151.602 1.00 77.45  ? 489 MET B O   1 
ATOM   5229 C CB  . MET B 1 489 ? 106.882 153.304 148.632 1.00 63.55  ? 489 MET B CB  1 
ATOM   5230 C CG  . MET B 1 489 ? 108.297 153.375 149.177 1.00 69.83  ? 489 MET B CG  1 
ATOM   5231 S SD  . MET B 1 489 ? 109.270 151.959 148.681 1.00 83.96  ? 489 MET B SD  1 
ATOM   5232 C CE  . MET B 1 489 ? 108.225 150.672 149.332 1.00 69.97  ? 489 MET B CE  1 
ATOM   5233 N N   . VAL B 1 490 ? 107.248 156.136 150.003 1.00 68.61  ? 490 VAL B N   1 
ATOM   5234 C CA  . VAL B 1 490 ? 107.992 156.935 150.969 1.00 67.57  ? 490 VAL B CA  1 
ATOM   5235 C C   . VAL B 1 490 ? 107.042 157.680 151.896 1.00 70.70  ? 490 VAL B C   1 
ATOM   5236 O O   . VAL B 1 490 ? 107.266 157.741 153.109 1.00 73.89  ? 490 VAL B O   1 
ATOM   5237 C CB  . VAL B 1 490 ? 108.958 157.891 150.248 1.00 67.37  ? 490 VAL B CB  1 
ATOM   5238 C CG1 . VAL B 1 490 ? 109.547 158.886 151.230 1.00 69.14  ? 490 VAL B CG1 1 
ATOM   5239 C CG2 . VAL B 1 490 ? 110.067 157.105 149.575 1.00 63.49  ? 490 VAL B CG2 1 
ATOM   5240 N N   . THR B 1 491 ? 105.963 158.251 151.353 1.00 67.63  ? 491 THR B N   1 
ATOM   5241 C CA  . THR B 1 491 ? 105.041 158.991 152.208 1.00 72.61  ? 491 THR B CA  1 
ATOM   5242 C C   . THR B 1 491 ? 104.303 158.058 153.161 1.00 75.27  ? 491 THR B C   1 
ATOM   5243 O O   . THR B 1 491 ? 104.050 158.421 154.316 1.00 78.19  ? 491 THR B O   1 
ATOM   5244 C CB  . THR B 1 491 ? 104.060 159.819 151.370 1.00 68.34  ? 491 THR B CB  1 
ATOM   5245 O OG1 . THR B 1 491 ? 103.289 160.661 152.235 1.00 79.04  ? 491 THR B OG1 1 
ATOM   5246 C CG2 . THR B 1 491 ? 103.116 158.940 150.578 1.00 65.36  ? 491 THR B CG2 1 
ATOM   5247 N N   . PHE B 1 492 ? 103.982 156.838 152.720 1.00 74.24  ? 492 PHE B N   1 
ATOM   5248 C CA  . PHE B 1 492 ? 103.307 155.913 153.623 1.00 75.83  ? 492 PHE B CA  1 
ATOM   5249 C C   . PHE B 1 492 ? 104.255 155.388 154.693 1.00 79.49  ? 492 PHE B C   1 
ATOM   5250 O O   . PHE B 1 492 ? 103.855 155.222 155.851 1.00 86.10  ? 492 PHE B O   1 
ATOM   5251 C CB  . PHE B 1 492 ? 102.671 154.776 152.829 1.00 70.34  ? 492 PHE B CB  1 
ATOM   5252 C CG  . PHE B 1 492 ? 101.358 155.150 152.213 1.00 70.80  ? 492 PHE B CG  1 
ATOM   5253 C CD1 . PHE B 1 492 ? 100.409 155.832 152.954 1.00 72.52  ? 492 PHE B CD1 1 
ATOM   5254 C CD2 . PHE B 1 492 ? 101.082 154.854 150.893 1.00 68.49  ? 492 PHE B CD2 1 
ATOM   5255 C CE1 . PHE B 1 492 ? 99.203  156.192 152.397 1.00 73.69  ? 492 PHE B CE1 1 
ATOM   5256 C CE2 . PHE B 1 492 ? 99.876  155.216 150.329 1.00 71.80  ? 492 PHE B CE2 1 
ATOM   5257 C CZ  . PHE B 1 492 ? 98.935  155.884 151.083 1.00 74.10  ? 492 PHE B CZ  1 
ATOM   5258 N N   . ALA B 1 493 ? 105.521 155.150 154.341 1.00 76.61  ? 493 ALA B N   1 
ATOM   5259 C CA  . ALA B 1 493 ? 106.502 154.790 155.360 1.00 79.45  ? 493 ALA B CA  1 
ATOM   5260 C C   . ALA B 1 493 ? 106.695 155.923 156.361 1.00 87.43  ? 493 ALA B C   1 
ATOM   5261 O O   . ALA B 1 493 ? 106.816 155.682 157.568 1.00 91.70  ? 493 ALA B O   1 
ATOM   5262 C CB  . ALA B 1 493 ? 107.830 154.420 154.704 1.00 79.30  ? 493 ALA B CB  1 
ATOM   5263 N N   . ALA B 1 494 ? 106.727 157.168 155.878 1.00 82.39  ? 494 ALA B N   1 
ATOM   5264 C CA  . ALA B 1 494 ? 106.884 158.311 156.770 1.00 79.02  ? 494 ALA B CA  1 
ATOM   5265 C C   . ALA B 1 494 ? 105.696 158.451 157.712 1.00 88.26  ? 494 ALA B C   1 
ATOM   5266 O O   . ALA B 1 494 ? 105.874 158.728 158.902 1.00 95.70  ? 494 ALA B O   1 
ATOM   5267 C CB  . ALA B 1 494 ? 107.077 159.590 155.957 1.00 74.30  ? 494 ALA B CB  1 
ATOM   5268 N N   . LEU B 1 495 ? 104.475 158.273 157.200 1.00 86.17  ? 495 LEU B N   1 
ATOM   5269 C CA  . LEU B 1 495 ? 103.302 158.326 158.067 1.00 87.84  ? 495 LEU B CA  1 
ATOM   5270 C C   . LEU B 1 495 ? 103.309 157.186 159.079 1.00 95.48  ? 495 LEU B C   1 
ATOM   5271 O O   . LEU B 1 495 ? 102.959 157.384 160.249 1.00 101.82 ? 495 LEU B O   1 
ATOM   5272 C CB  . LEU B 1 495 ? 102.025 158.296 157.230 1.00 89.50  ? 495 LEU B CB  1 
ATOM   5273 C CG  . LEU B 1 495 ? 101.785 159.519 156.344 1.00 89.67  ? 495 LEU B CG  1 
ATOM   5274 C CD1 . LEU B 1 495 ? 100.476 159.387 155.585 1.00 87.35  ? 495 LEU B CD1 1 
ATOM   5275 C CD2 . LEU B 1 495 ? 101.803 160.791 157.173 1.00 90.01  ? 495 LEU B CD2 1 
ATOM   5276 N N   . TYR B 1 496 ? 103.714 155.988 158.650 1.00 93.11  ? 496 TYR B N   1 
ATOM   5277 C CA  . TYR B 1 496 ? 103.808 154.859 159.569 1.00 95.42  ? 496 TYR B CA  1 
ATOM   5278 C C   . TYR B 1 496 ? 104.810 155.136 160.682 1.00 100.91 ? 496 TYR B C   1 
ATOM   5279 O O   . TYR B 1 496 ? 104.565 154.797 161.845 1.00 106.03 ? 496 TYR B O   1 
ATOM   5280 C CB  . TYR B 1 496 ? 104.192 153.597 158.796 1.00 93.35  ? 496 TYR B CB  1 
ATOM   5281 C CG  . TYR B 1 496 ? 104.558 152.410 159.659 1.00 101.34 ? 496 TYR B CG  1 
ATOM   5282 C CD1 . TYR B 1 496 ? 105.884 152.132 159.966 1.00 100.21 ? 496 TYR B CD1 1 
ATOM   5283 C CD2 . TYR B 1 496 ? 103.581 151.561 160.155 1.00 99.62  ? 496 TYR B CD2 1 
ATOM   5284 C CE1 . TYR B 1 496 ? 106.223 151.046 160.750 1.00 100.49 ? 496 TYR B CE1 1 
ATOM   5285 C CE2 . TYR B 1 496 ? 103.912 150.473 160.939 1.00 101.68 ? 496 TYR B CE2 1 
ATOM   5286 C CZ  . TYR B 1 496 ? 105.233 150.221 161.233 1.00 103.17 ? 496 TYR B CZ  1 
ATOM   5287 O OH  . TYR B 1 496 ? 105.562 149.138 162.014 1.00 103.84 ? 496 TYR B OH  1 
ATOM   5288 N N   . SER B 1 497 ? 105.948 155.746 160.345 1.00 98.31  ? 497 SER B N   1 
ATOM   5289 C CA  . SER B 1 497 ? 106.959 156.032 161.358 1.00 100.68 ? 497 SER B CA  1 
ATOM   5290 C C   . SER B 1 497 ? 106.534 157.180 162.267 1.00 101.88 ? 497 SER B C   1 
ATOM   5291 O O   . SER B 1 497 ? 106.872 157.192 163.456 1.00 105.55 ? 497 SER B O   1 
ATOM   5292 C CB  . SER B 1 497 ? 108.298 156.334 160.692 1.00 100.16 ? 497 SER B CB  1 
ATOM   5293 O OG  . SER B 1 497 ? 108.842 155.157 160.125 1.00 100.98 ? 497 SER B OG  1 
ATOM   5294 N N   . THR B 1 498 ? 105.815 158.166 161.724 1.00 97.86  ? 498 THR B N   1 
ATOM   5295 C CA  . THR B 1 498 ? 105.261 159.221 162.568 1.00 103.31 ? 498 THR B CA  1 
ATOM   5296 C C   . THR B 1 498 ? 104.271 158.643 163.568 1.00 114.09 ? 498 THR B C   1 
ATOM   5297 O O   . THR B 1 498 ? 104.280 159.009 164.749 1.00 124.48 ? 498 THR B O   1 
ATOM   5298 C CB  . THR B 1 498 ? 104.596 160.294 161.706 1.00 102.90 ? 498 THR B CB  1 
ATOM   5299 O OG1 . THR B 1 498 ? 105.585 160.930 160.887 1.00 97.48  ? 498 THR B OG1 1 
ATOM   5300 C CG2 . THR B 1 498 ? 103.922 161.341 162.580 1.00 106.68 ? 498 THR B CG2 1 
ATOM   5301 N N   . HIS B 1 499 ? 103.419 157.728 163.116 1.00 111.58 ? 499 HIS B N   1 
ATOM   5302 C CA  . HIS B 1 499 ? 102.613 156.938 164.031 1.00 111.87 ? 499 HIS B CA  1 
ATOM   5303 C C   . HIS B 1 499 ? 103.488 155.862 164.672 1.00 113.80 ? 499 HIS B C   1 
ATOM   5304 O O   . HIS B 1 499 ? 104.694 155.774 164.423 1.00 114.47 ? 499 HIS B O   1 
ATOM   5305 C CB  . HIS B 1 499 ? 101.417 156.340 163.297 1.00 111.43 ? 499 HIS B CB  1 
ATOM   5306 C CG  . HIS B 1 499 ? 100.454 157.366 162.784 1.00 117.22 ? 499 HIS B CG  1 
ATOM   5307 N ND1 . HIS B 1 499 ? 99.118  157.366 163.121 1.00 120.99 ? 499 HIS B ND1 1 
ATOM   5308 C CD2 . HIS B 1 499 ? 100.637 158.431 161.968 1.00 115.04 ? 499 HIS B CD2 1 
ATOM   5309 C CE1 . HIS B 1 499 ? 98.517  158.383 162.528 1.00 117.19 ? 499 HIS B CE1 1 
ATOM   5310 N NE2 . HIS B 1 499 ? 99.417  159.046 161.824 1.00 114.35 ? 499 HIS B NE2 1 
ATOM   5311 N N   . LYS B 1 500 ? 102.881 155.054 165.539 1.00 117.08 ? 500 LYS B N   1 
ATOM   5312 C CA  . LYS B 1 500 ? 103.541 154.019 166.334 1.00 119.75 ? 500 LYS B CA  1 
ATOM   5313 C C   . LYS B 1 500 ? 104.484 154.618 167.372 1.00 124.46 ? 500 LYS B C   1 
ATOM   5314 O O   . LYS B 1 500 ? 105.049 153.876 168.185 1.00 125.77 ? 500 LYS B O   1 
ATOM   5315 C CB  . LYS B 1 500 ? 104.310 153.008 165.466 1.00 112.57 ? 500 LYS B CB  1 
ATOM   5316 C CG  . LYS B 1 500 ? 104.561 151.660 166.124 1.00 112.86 ? 500 LYS B CG  1 
ATOM   5317 C CD  . LYS B 1 500 ? 105.448 150.779 165.260 1.00 107.51 ? 500 LYS B CD  1 
ATOM   5318 C CE  . LYS B 1 500 ? 105.738 149.454 165.944 1.00 104.83 ? 500 LYS B CE  1 
ATOM   5319 N NZ  . LYS B 1 500 ? 106.649 148.599 165.138 1.00 106.16 ? 500 LYS B NZ  1 
ATOM   5320 N N   . GLU B 1 501 ? 104.662 155.933 167.382 1.00 126.22 ? 501 GLU B N   1 
ATOM   5321 C CA  . GLU B 1 501 ? 105.436 156.647 168.388 1.00 130.10 ? 501 GLU B CA  1 
ATOM   5322 C C   . GLU B 1 501 ? 104.618 157.708 169.101 1.00 132.64 ? 501 GLU B C   1 
ATOM   5323 O O   . GLU B 1 501 ? 104.800 157.920 170.303 1.00 133.65 ? 501 GLU B O   1 
ATOM   5324 C CB  . GLU B 1 501 ? 106.671 157.294 167.742 1.00 128.76 ? 501 GLU B CB  1 
ATOM   5325 C CG  . GLU B 1 501 ? 107.556 158.068 168.707 1.00 136.08 ? 501 GLU B CG  1 
ATOM   5326 C CD  . GLU B 1 501 ? 108.743 158.711 168.018 1.00 135.25 ? 501 GLU B CD  1 
ATOM   5327 O OE1 . GLU B 1 501 ? 108.931 158.471 166.806 1.00 131.55 ? 501 GLU B OE1 1 
ATOM   5328 O OE2 . GLU B 1 501 ? 109.489 159.457 168.686 1.00 131.25 ? 501 GLU B OE2 1 
ATOM   5329 N N   . ARG B 1 502 ? 103.712 158.373 168.390 1.00 132.56 ? 502 ARG B N   1 
ATOM   5330 C CA  . ARG B 1 502 ? 102.783 159.319 168.988 1.00 137.10 ? 502 ARG B CA  1 
ATOM   5331 C C   . ARG B 1 502 ? 101.483 158.663 169.430 1.00 139.66 ? 502 ARG B C   1 
ATOM   5332 O O   . ARG B 1 502 ? 100.642 159.334 170.038 1.00 140.60 ? 502 ARG B O   1 
ATOM   5333 C CB  . ARG B 1 502 ? 102.486 160.455 168.004 1.00 137.08 ? 502 ARG B CB  1 
ATOM   5334 C CG  . ARG B 1 502 ? 103.720 161.227 167.565 1.00 133.46 ? 502 ARG B CG  1 
ATOM   5335 C CD  . ARG B 1 502 ? 103.365 162.336 166.590 1.00 132.53 ? 502 ARG B CD  1 
ATOM   5336 N NE  . ARG B 1 502 ? 102.468 163.320 167.182 1.00 138.46 ? 502 ARG B NE  1 
ATOM   5337 C CZ  . ARG B 1 502 ? 101.986 164.376 166.541 1.00 134.06 ? 502 ARG B CZ  1 
ATOM   5338 N NH1 . ARG B 1 502 ? 102.296 164.618 165.278 1.00 132.11 ? 502 ARG B NH1 1 
ATOM   5339 N NH2 . ARG B 1 502 ? 101.174 165.211 167.184 1.00 127.13 ? 502 ARG B NH2 1 
ATOM   5340 N N   . GLY B 1 503 ? 101.299 157.375 169.143 1.00 135.92 ? 503 GLY B N   1 
ATOM   5341 C CA  . GLY B 1 503 ? 100.147 156.633 169.618 1.00 135.58 ? 503 GLY B CA  1 
ATOM   5342 C C   . GLY B 1 503 ? 98.809  157.121 169.102 1.00 136.03 ? 503 GLY B C   1 
ATOM   5343 O O   . GLY B 1 503 ? 97.862  157.278 169.880 1.00 137.03 ? 503 GLY B O   1 
ATOM   5344 N N   . HIS B 1 504 ? 98.711  157.366 167.798 1.00 134.18 ? 504 HIS B N   1 
ATOM   5345 C CA  . HIS B 1 504 ? 97.469  157.824 167.191 1.00 133.35 ? 504 HIS B CA  1 
ATOM   5346 C C   . HIS B 1 504 ? 96.525  156.685 166.827 1.00 130.51 ? 504 HIS B C   1 
ATOM   5347 O O   . HIS B 1 504 ? 95.433  156.949 166.313 1.00 127.91 ? 504 HIS B O   1 
ATOM   5348 C CB  . HIS B 1 504 ? 97.765  158.662 165.944 1.00 135.10 ? 504 HIS B CB  1 
ATOM   5349 C CG  . HIS B 1 504 ? 98.407  159.981 166.241 1.00 141.88 ? 504 HIS B CG  1 
ATOM   5350 N ND1 . HIS B 1 504 ? 97.727  161.022 166.836 1.00 141.39 ? 504 HIS B ND1 1 
ATOM   5351 C CD2 . HIS B 1 504 ? 99.665  160.431 166.022 1.00 138.22 ? 504 HIS B CD2 1 
ATOM   5352 C CE1 . HIS B 1 504 ? 98.539  162.055 166.974 1.00 137.76 ? 504 HIS B CE1 1 
ATOM   5353 N NE2 . HIS B 1 504 ? 99.721  161.722 166.487 1.00 139.79 ? 504 HIS B NE2 1 
ATOM   5354 N N   . SER B 1 505 ? 96.923  155.436 167.065 1.00 130.67 ? 505 SER B N   1 
ATOM   5355 C CA  . SER B 1 505 ? 96.122  154.240 166.817 1.00 130.74 ? 505 SER B CA  1 
ATOM   5356 C C   . SER B 1 505 ? 95.782  154.040 165.344 1.00 130.36 ? 505 SER B C   1 
ATOM   5357 O O   . SER B 1 505 ? 94.949  153.187 165.016 1.00 127.02 ? 505 SER B O   1 
ATOM   5358 C CB  . SER B 1 505 ? 94.832  154.242 167.651 1.00 127.59 ? 505 SER B CB  1 
ATOM   5359 O OG  . SER B 1 505 ? 95.122  154.261 169.038 1.00 123.47 ? 505 SER B OG  1 
ATOM   5360 N N   . ASP B 1 506 ? 96.403  154.803 164.444 1.00 131.22 ? 506 ASP B N   1 
ATOM   5361 C CA  . ASP B 1 506 ? 96.251  154.612 163.008 1.00 127.19 ? 506 ASP B CA  1 
ATOM   5362 C C   . ASP B 1 506 ? 97.476  153.954 162.387 1.00 122.81 ? 506 ASP B C   1 
ATOM   5363 O O   . ASP B 1 506 ? 97.739  154.142 161.195 1.00 120.32 ? 506 ASP B O   1 
ATOM   5364 C CB  . ASP B 1 506 ? 95.963  155.948 162.320 1.00 126.67 ? 506 ASP B CB  1 
ATOM   5365 C CG  . ASP B 1 506 ? 94.577  156.475 162.628 1.00 129.01 ? 506 ASP B CG  1 
ATOM   5366 O OD1 . ASP B 1 506 ? 93.661  155.653 162.840 1.00 128.82 ? 506 ASP B OD1 1 
ATOM   5367 O OD2 . ASP B 1 506 ? 94.404  157.712 162.656 1.00 128.25 ? 506 ASP B OD2 1 
ATOM   5368 N N   . THR B 1 507 ? 98.233  153.192 163.176 1.00 122.49 ? 507 THR B N   1 
ATOM   5369 C CA  . THR B 1 507 ? 99.468  152.601 162.676 1.00 118.11 ? 507 THR B CA  1 
ATOM   5370 C C   . THR B 1 507 ? 99.191  151.429 161.743 1.00 113.33 ? 507 THR B C   1 
ATOM   5371 O O   . THR B 1 507 ? 99.894  151.249 160.742 1.00 112.00 ? 507 THR B O   1 
ATOM   5372 C CB  . THR B 1 507 ? 100.342 152.158 163.849 1.00 116.67 ? 507 THR B CB  1 
ATOM   5373 O OG1 . THR B 1 507 ? 100.569 153.271 164.721 1.00 116.92 ? 507 THR B OG1 1 
ATOM   5374 C CG2 . THR B 1 507 ? 101.677 151.634 163.353 1.00 111.49 ? 507 THR B CG2 1 
ATOM   5375 N N   . MET B 1 508 ? 98.177  150.618 162.054 1.00 114.03 ? 508 MET B N   1 
ATOM   5376 C CA  . MET B 1 508 ? 97.940  149.400 161.283 1.00 116.77 ? 508 MET B CA  1 
ATOM   5377 C C   . MET B 1 508 ? 97.517  149.709 159.851 1.00 114.31 ? 508 MET B C   1 
ATOM   5378 O O   . MET B 1 508 ? 97.973  149.048 158.910 1.00 110.75 ? 508 MET B O   1 
ATOM   5379 C CB  . MET B 1 508 ? 96.891  148.535 161.979 1.00 119.74 ? 508 MET B CB  1 
ATOM   5380 C CG  . MET B 1 508 ? 97.333  148.002 163.331 1.00 123.21 ? 508 MET B CG  1 
ATOM   5381 S SD  . MET B 1 508 ? 98.903  147.115 163.246 1.00 140.12 ? 508 MET B SD  1 
ATOM   5382 C CE  . MET B 1 508 ? 98.506  145.823 162.070 1.00 117.39 ? 508 MET B CE  1 
ATOM   5383 N N   . VAL B 1 509 ? 96.640  150.697 159.663 1.00 113.13 ? 509 VAL B N   1 
ATOM   5384 C CA  . VAL B 1 509 ? 96.196  151.034 158.315 1.00 111.01 ? 509 VAL B CA  1 
ATOM   5385 C C   . VAL B 1 509 ? 97.358  151.568 157.486 1.00 108.85 ? 509 VAL B C   1 
ATOM   5386 O O   . VAL B 1 509 ? 97.510  151.222 156.308 1.00 104.06 ? 509 VAL B O   1 
ATOM   5387 C CB  . VAL B 1 509 ? 95.019  152.027 158.365 1.00 112.96 ? 509 VAL B CB  1 
ATOM   5388 C CG1 . VAL B 1 509 ? 93.773  151.338 158.897 1.00 114.01 ? 509 VAL B CG1 1 
ATOM   5389 C CG2 . VAL B 1 509 ? 95.361  153.232 159.224 1.00 113.20 ? 509 VAL B CG2 1 
ATOM   5390 N N   . PHE B 1 510 ? 98.203  152.409 158.088 1.00 110.11 ? 510 PHE B N   1 
ATOM   5391 C CA  . PHE B 1 510 ? 99.370  152.917 157.377 1.00 103.87 ? 510 PHE B CA  1 
ATOM   5392 C C   . PHE B 1 510 ? 100.348 151.798 157.046 1.00 99.45  ? 510 PHE B C   1 
ATOM   5393 O O   . PHE B 1 510 ? 100.941 151.791 155.964 1.00 94.74  ? 510 PHE B O   1 
ATOM   5394 C CB  . PHE B 1 510 ? 100.052 154.009 158.199 1.00 101.90 ? 510 PHE B CB  1 
ATOM   5395 C CG  . PHE B 1 510 ? 99.346  155.331 158.145 1.00 103.87 ? 510 PHE B CG  1 
ATOM   5396 C CD1 . PHE B 1 510 ? 98.704  155.737 156.988 1.00 99.58  ? 510 PHE B CD1 1 
ATOM   5397 C CD2 . PHE B 1 510 ? 99.316  156.163 159.249 1.00 108.64 ? 510 PHE B CD2 1 
ATOM   5398 C CE1 . PHE B 1 510 ? 98.050  156.950 156.932 1.00 96.70  ? 510 PHE B CE1 1 
ATOM   5399 C CE2 . PHE B 1 510 ? 98.662  157.377 159.198 1.00 104.97 ? 510 PHE B CE2 1 
ATOM   5400 C CZ  . PHE B 1 510 ? 98.029  157.771 158.038 1.00 97.82  ? 510 PHE B CZ  1 
ATOM   5401 N N   . PHE B 1 511 ? 100.530 150.844 157.962 1.00 100.74 ? 511 PHE B N   1 
ATOM   5402 C CA  . PHE B 1 511 ? 101.404 149.708 157.686 1.00 98.90  ? 511 PHE B CA  1 
ATOM   5403 C C   . PHE B 1 511 ? 100.871 148.871 156.531 1.00 95.11  ? 511 PHE B C   1 
ATOM   5404 O O   . PHE B 1 511 ? 101.637 148.433 155.665 1.00 92.34  ? 511 PHE B O   1 
ATOM   5405 C CB  . PHE B 1 511 ? 101.559 148.851 158.941 1.00 102.47 ? 511 PHE B CB  1 
ATOM   5406 C CG  . PHE B 1 511 ? 102.400 147.623 158.738 1.00 102.85 ? 511 PHE B CG  1 
ATOM   5407 C CD1 . PHE B 1 511 ? 103.780 147.694 158.801 1.00 99.04  ? 511 PHE B CD1 1 
ATOM   5408 C CD2 . PHE B 1 511 ? 101.809 146.395 158.494 1.00 105.95 ? 511 PHE B CD2 1 
ATOM   5409 C CE1 . PHE B 1 511 ? 104.555 146.567 158.617 1.00 99.04  ? 511 PHE B CE1 1 
ATOM   5410 C CE2 . PHE B 1 511 ? 102.579 145.264 158.308 1.00 102.73 ? 511 PHE B CE2 1 
ATOM   5411 C CZ  . PHE B 1 511 ? 103.953 145.350 158.371 1.00 100.11 ? 511 PHE B CZ  1 
ATOM   5412 N N   . TYR B 1 512 ? 99.559  148.631 156.505 1.00 96.56  ? 512 TYR B N   1 
ATOM   5413 C CA  . TYR B 1 512 ? 98.973  147.868 155.408 1.00 98.85  ? 512 TYR B CA  1 
ATOM   5414 C C   . TYR B 1 512 ? 99.126  148.603 154.082 1.00 92.44  ? 512 TYR B C   1 
ATOM   5415 O O   . TYR B 1 512 ? 99.464  147.993 153.060 1.00 81.33  ? 512 TYR B O   1 
ATOM   5416 C CB  . TYR B 1 512 ? 97.501  147.577 155.697 1.00 106.01 ? 512 TYR B CB  1 
ATOM   5417 C CG  . TYR B 1 512 ? 97.287  146.614 156.842 1.00 110.37 ? 512 TYR B CG  1 
ATOM   5418 C CD1 . TYR B 1 512 ? 98.284  145.726 157.221 1.00 108.39 ? 512 TYR B CD1 1 
ATOM   5419 C CD2 . TYR B 1 512 ? 96.090  146.594 157.542 1.00 114.36 ? 512 TYR B CD2 1 
ATOM   5420 C CE1 . TYR B 1 512 ? 98.094  144.844 158.264 1.00 115.04 ? 512 TYR B CE1 1 
ATOM   5421 C CE2 . TYR B 1 512 ? 95.891  145.715 158.587 1.00 115.99 ? 512 TYR B CE2 1 
ATOM   5422 C CZ  . TYR B 1 512 ? 96.896  144.843 158.945 1.00 119.30 ? 512 TYR B CZ  1 
ATOM   5423 O OH  . TYR B 1 512 ? 96.702  143.965 159.986 1.00 121.35 ? 512 TYR B OH  1 
ATOM   5424 N N   . LEU B 1 513 ? 98.886  149.917 154.080 1.00 94.36  ? 513 LEU B N   1 
ATOM   5425 C CA  . LEU B 1 513 ? 99.060  150.694 152.858 1.00 86.07  ? 513 LEU B CA  1 
ATOM   5426 C C   . LEU B 1 513 ? 100.512 150.682 152.401 1.00 81.39  ? 513 LEU B C   1 
ATOM   5427 O O   . LEU B 1 513 ? 100.793 150.590 151.200 1.00 77.76  ? 513 LEU B O   1 
ATOM   5428 C CB  . LEU B 1 513 ? 98.574  152.126 153.070 1.00 80.20  ? 513 LEU B CB  1 
ATOM   5429 C CG  . LEU B 1 513 ? 97.071  152.293 153.283 1.00 84.14  ? 513 LEU B CG  1 
ATOM   5430 C CD1 . LEU B 1 513 ? 96.713  153.759 153.444 1.00 83.62  ? 513 LEU B CD1 1 
ATOM   5431 C CD2 . LEU B 1 513 ? 96.302  151.676 152.130 1.00 86.46  ? 513 LEU B CD2 1 
ATOM   5432 N N   . TRP B 1 514 ? 101.450 150.774 153.345 1.00 81.85  ? 514 TRP B N   1 
ATOM   5433 C CA  . TRP B 1 514 ? 102.861 150.730 152.986 1.00 74.59  ? 514 TRP B CA  1 
ATOM   5434 C C   . TRP B 1 514 ? 103.246 149.375 152.413 1.00 76.93  ? 514 TRP B C   1 
ATOM   5435 O O   . TRP B 1 514 ? 104.045 149.305 151.480 1.00 79.18  ? 514 TRP B O   1 
ATOM   5436 C CB  . TRP B 1 514 ? 103.740 151.057 154.189 1.00 74.74  ? 514 TRP B CB  1 
ATOM   5437 C CG  . TRP B 1 514 ? 105.183 150.839 153.886 1.00 78.54  ? 514 TRP B CG  1 
ATOM   5438 C CD1 . TRP B 1 514 ? 105.991 151.640 153.139 1.00 81.00  ? 514 TRP B CD1 1 
ATOM   5439 C CD2 . TRP B 1 514 ? 105.988 149.730 154.300 1.00 82.48  ? 514 TRP B CD2 1 
ATOM   5440 N NE1 . TRP B 1 514 ? 107.253 151.106 153.068 1.00 82.26  ? 514 TRP B NE1 1 
ATOM   5441 C CE2 . TRP B 1 514 ? 107.277 149.933 153.774 1.00 82.50  ? 514 TRP B CE2 1 
ATOM   5442 C CE3 . TRP B 1 514 ? 105.745 148.589 155.069 1.00 87.23  ? 514 TRP B CE3 1 
ATOM   5443 C CZ2 . TRP B 1 514 ? 108.321 149.038 153.992 1.00 82.05  ? 514 TRP B CZ2 1 
ATOM   5444 C CZ3 . TRP B 1 514 ? 106.783 147.703 155.285 1.00 95.79  ? 514 TRP B CZ3 1 
ATOM   5445 C CH2 . TRP B 1 514 ? 108.054 147.931 154.747 1.00 92.11  ? 514 TRP B CH2 1 
ATOM   5446 N N   . ILE B 1 515 ? 102.705 148.286 152.963 1.00 79.37  ? 515 ILE B N   1 
ATOM   5447 C CA  . ILE B 1 515 ? 102.982 146.964 152.402 1.00 77.82  ? 515 ILE B CA  1 
ATOM   5448 C C   . ILE B 1 515 ? 102.421 146.857 150.989 1.00 74.80  ? 515 ILE B C   1 
ATOM   5449 O O   . ILE B 1 515 ? 103.086 146.349 150.071 1.00 69.52  ? 515 ILE B O   1 
ATOM   5450 C CB  . ILE B 1 515 ? 102.419 145.864 153.320 1.00 79.43  ? 515 ILE B CB  1 
ATOM   5451 C CG1 . ILE B 1 515 ? 103.332 145.661 154.528 1.00 80.89  ? 515 ILE B CG1 1 
ATOM   5452 C CG2 . ILE B 1 515 ? 102.256 144.560 152.559 1.00 74.70  ? 515 ILE B CG2 1 
ATOM   5453 C CD1 . ILE B 1 515 ? 104.696 145.135 154.164 1.00 74.97  ? 515 ILE B CD1 1 
ATOM   5454 N N   . VAL B 1 516 ? 101.193 147.340 150.791 1.00 78.19  ? 516 VAL B N   1 
ATOM   5455 C CA  . VAL B 1 516 ? 100.573 147.276 149.470 1.00 73.63  ? 516 VAL B CA  1 
ATOM   5456 C C   . VAL B 1 516 ? 101.407 148.049 148.459 1.00 65.30  ? 516 VAL B C   1 
ATOM   5457 O O   . VAL B 1 516 ? 101.699 147.558 147.363 1.00 67.35  ? 516 VAL B O   1 
ATOM   5458 C CB  . VAL B 1 516 ? 99.127  147.799 149.527 1.00 69.64  ? 516 VAL B CB  1 
ATOM   5459 C CG1 . VAL B 1 516 ? 98.576  147.979 148.125 1.00 60.18  ? 516 VAL B CG1 1 
ATOM   5460 C CG2 . VAL B 1 516 ? 98.253  146.845 150.318 1.00 74.15  ? 516 VAL B CG2 1 
ATOM   5461 N N   . PHE B 1 517 ? 101.831 149.259 148.821 1.00 61.59  ? 517 PHE B N   1 
ATOM   5462 C CA  . PHE B 1 517 ? 102.612 150.059 147.889 1.00 60.60  ? 517 PHE B CA  1 
ATOM   5463 C C   . PHE B 1 517 ? 104.059 149.601 147.778 1.00 59.44  ? 517 PHE B C   1 
ATOM   5464 O O   . PHE B 1 517 ? 104.692 149.869 146.759 1.00 59.85  ? 517 PHE B O   1 
ATOM   5465 C CB  . PHE B 1 517 ? 102.536 151.534 148.269 1.00 59.92  ? 517 PHE B CB  1 
ATOM   5466 C CG  . PHE B 1 517 ? 101.297 152.208 147.769 1.00 61.33  ? 517 PHE B CG  1 
ATOM   5467 C CD1 . PHE B 1 517 ? 101.247 152.722 146.487 1.00 62.13  ? 517 PHE B CD1 1 
ATOM   5468 C CD2 . PHE B 1 517 ? 100.170 152.298 148.564 1.00 61.64  ? 517 PHE B CD2 1 
ATOM   5469 C CE1 . PHE B 1 517 ? 100.105 153.331 146.015 1.00 65.16  ? 517 PHE B CE1 1 
ATOM   5470 C CE2 . PHE B 1 517 ? 99.024  152.905 148.095 1.00 59.47  ? 517 PHE B CE2 1 
ATOM   5471 C CZ  . PHE B 1 517 ? 98.993  153.424 146.820 1.00 64.35  ? 517 PHE B CZ  1 
ATOM   5472 N N   . TYR B 1 518 ? 104.582 148.882 148.771 1.00 60.35  ? 518 TYR B N   1 
ATOM   5473 C CA  . TYR B 1 518 ? 105.874 148.226 148.617 1.00 56.67  ? 518 TYR B CA  1 
ATOM   5474 C C   . TYR B 1 518 ? 105.803 147.156 147.542 1.00 57.57  ? 518 TYR B C   1 
ATOM   5475 O O   . TYR B 1 518 ? 106.650 147.105 146.640 1.00 58.59  ? 518 TYR B O   1 
ATOM   5476 C CB  . TYR B 1 518 ? 106.313 147.625 149.954 1.00 59.74  ? 518 TYR B CB  1 
ATOM   5477 C CG  . TYR B 1 518 ? 107.549 146.752 149.891 1.00 59.81  ? 518 TYR B CG  1 
ATOM   5478 C CD1 . TYR B 1 518 ? 107.449 145.384 149.674 1.00 63.96  ? 518 TYR B CD1 1 
ATOM   5479 C CD2 . TYR B 1 518 ? 108.812 147.292 150.072 1.00 62.19  ? 518 TYR B CD2 1 
ATOM   5480 C CE1 . TYR B 1 518 ? 108.574 144.585 149.621 1.00 57.63  ? 518 TYR B CE1 1 
ATOM   5481 C CE2 . TYR B 1 518 ? 109.939 146.499 150.025 1.00 57.49  ? 518 TYR B CE2 1 
ATOM   5482 C CZ  . TYR B 1 518 ? 109.815 145.149 149.799 1.00 54.50  ? 518 TYR B CZ  1 
ATOM   5483 O OH  . TYR B 1 518 ? 110.939 144.362 149.749 1.00 56.38  ? 518 TYR B OH  1 
ATOM   5484 N N   . ILE B 1 519 ? 104.782 146.301 147.615 1.00 61.41  ? 519 ILE B N   1 
ATOM   5485 C CA  . ILE B 1 519 ? 104.590 145.297 146.573 1.00 59.77  ? 519 ILE B CA  1 
ATOM   5486 C C   . ILE B 1 519 ? 104.374 145.973 145.226 1.00 54.16  ? 519 ILE B C   1 
ATOM   5487 O O   . ILE B 1 519 ? 104.952 145.565 144.211 1.00 52.80  ? 519 ILE B O   1 
ATOM   5488 C CB  . ILE B 1 519 ? 103.423 144.358 146.936 1.00 56.98  ? 519 ILE B CB  1 
ATOM   5489 C CG1 . ILE B 1 519 ? 103.925 143.158 147.742 1.00 54.85  ? 519 ILE B CG1 1 
ATOM   5490 C CG2 . ILE B 1 519 ? 102.707 143.875 145.685 1.00 58.27  ? 519 ILE B CG2 1 
ATOM   5491 C CD1 . ILE B 1 519 ? 104.407 143.493 149.133 1.00 56.01  ? 519 ILE B CD1 1 
ATOM   5492 N N   . ILE B 1 520 ? 103.560 147.031 145.200 1.00 52.63  ? 520 ILE B N   1 
ATOM   5493 C CA  . ILE B 1 520 ? 103.244 147.703 143.942 1.00 50.39  ? 520 ILE B CA  1 
ATOM   5494 C C   . ILE B 1 520 ? 104.500 148.303 143.322 1.00 53.55  ? 520 ILE B C   1 
ATOM   5495 O O   . ILE B 1 520 ? 104.764 148.128 142.129 1.00 55.06  ? 520 ILE B O   1 
ATOM   5496 C CB  . ILE B 1 520 ? 102.156 148.768 144.161 1.00 49.45  ? 520 ILE B CB  1 
ATOM   5497 C CG1 . ILE B 1 520 ? 100.797 148.100 144.373 1.00 52.83  ? 520 ILE B CG1 1 
ATOM   5498 C CG2 . ILE B 1 520 ? 102.096 149.724 142.985 1.00 48.36  ? 520 ILE B CG2 1 
ATOM   5499 C CD1 . ILE B 1 520 ? 99.666  149.074 144.590 1.00 57.35  ? 520 ILE B CD1 1 
ATOM   5500 N N   . SER B 1 521 ? 105.299 149.011 144.122 1.00 52.78  ? 521 SER B N   1 
ATOM   5501 C CA  . SER B 1 521 ? 106.506 149.644 143.604 1.00 48.37  ? 521 SER B CA  1 
ATOM   5502 C C   . SER B 1 521 ? 107.520 148.608 143.141 1.00 54.46  ? 521 SER B C   1 
ATOM   5503 O O   . SER B 1 521 ? 108.116 148.749 142.066 1.00 53.33  ? 521 SER B O   1 
ATOM   5504 C CB  . SER B 1 521 ? 107.115 150.553 144.669 1.00 48.81  ? 521 SER B CB  1 
ATOM   5505 O OG  . SER B 1 521 ? 108.306 151.156 144.201 1.00 54.82  ? 521 SER B OG  1 
ATOM   5506 N N   . SER B 1 522 ? 107.733 147.557 143.939 1.00 55.75  ? 522 SER B N   1 
ATOM   5507 C CA  . SER B 1 522 ? 108.702 146.535 143.559 1.00 47.38  ? 522 SER B CA  1 
ATOM   5508 C C   . SER B 1 522 ? 108.292 145.853 142.263 1.00 50.58  ? 522 SER B C   1 
ATOM   5509 O O   . SER B 1 522 ? 109.105 145.707 141.343 1.00 55.52  ? 522 SER B O   1 
ATOM   5510 C CB  . SER B 1 522 ? 108.853 145.511 144.682 1.00 51.14  ? 522 SER B CB  1 
ATOM   5511 O OG  . SER B 1 522 ? 109.218 146.136 145.897 1.00 59.98  ? 522 SER B OG  1 
ATOM   5512 N N   . CYS B 1 523 ? 107.023 145.449 142.160 1.00 49.46  ? 523 CYS B N   1 
ATOM   5513 C CA  . CYS B 1 523 ? 106.555 144.794 140.945 1.00 49.25  ? 523 CYS B CA  1 
ATOM   5514 C C   . CYS B 1 523 ? 106.606 145.737 139.751 1.00 46.06  ? 523 CYS B C   1 
ATOM   5515 O O   . CYS B 1 523 ? 107.000 145.331 138.655 1.00 41.50  ? 523 CYS B O   1 
ATOM   5516 C CB  . CYS B 1 523 ? 105.139 144.260 141.150 1.00 53.88  ? 523 CYS B CB  1 
ATOM   5517 S SG  . CYS B 1 523 ? 105.014 142.938 142.372 1.00 79.46  ? 523 CYS B SG  1 
ATOM   5518 N N   . TYR B 1 524 ? 106.219 146.999 139.944 1.00 46.38  ? 524 TYR B N   1 
ATOM   5519 C CA  . TYR B 1 524 ? 106.225 147.970 138.857 1.00 43.83  ? 524 TYR B CA  1 
ATOM   5520 C C   . TYR B 1 524 ? 107.629 148.159 138.302 1.00 44.37  ? 524 TYR B C   1 
ATOM   5521 O O   . TYR B 1 524 ? 107.857 148.042 137.091 1.00 45.35  ? 524 TYR B O   1 
ATOM   5522 C CB  . TYR B 1 524 ? 105.661 149.293 139.374 1.00 43.82  ? 524 TYR B CB  1 
ATOM   5523 C CG  . TYR B 1 524 ? 104.940 150.146 138.360 1.00 41.07  ? 524 TYR B CG  1 
ATOM   5524 C CD1 . TYR B 1 524 ? 105.315 150.154 137.027 1.00 39.70  ? 524 TYR B CD1 1 
ATOM   5525 C CD2 . TYR B 1 524 ? 103.882 150.952 138.747 1.00 37.37  ? 524 TYR B CD2 1 
ATOM   5526 C CE1 . TYR B 1 524 ? 104.654 150.941 136.110 1.00 39.65  ? 524 TYR B CE1 1 
ATOM   5527 C CE2 . TYR B 1 524 ? 103.218 151.738 137.841 1.00 36.02  ? 524 TYR B CE2 1 
ATOM   5528 C CZ  . TYR B 1 524 ? 103.606 151.731 136.525 1.00 40.86  ? 524 TYR B CZ  1 
ATOM   5529 O OH  . TYR B 1 524 ? 102.936 152.520 135.623 1.00 48.57  ? 524 TYR B OH  1 
ATOM   5530 N N   . THR B 1 525 ? 108.592 148.431 139.186 1.00 45.38  ? 525 THR B N   1 
ATOM   5531 C CA  . THR B 1 525 ? 109.964 148.647 138.744 1.00 43.22  ? 525 THR B CA  1 
ATOM   5532 C C   . THR B 1 525 ? 110.556 147.384 138.131 1.00 43.83  ? 525 THR B C   1 
ATOM   5533 O O   . THR B 1 525 ? 111.263 147.454 137.120 1.00 41.85  ? 525 THR B O   1 
ATOM   5534 C CB  . THR B 1 525 ? 110.817 149.133 139.913 1.00 45.96  ? 525 THR B CB  1 
ATOM   5535 O OG1 . THR B 1 525 ? 110.686 148.223 141.010 1.00 50.77  ? 525 THR B OG1 1 
ATOM   5536 C CG2 . THR B 1 525 ? 110.365 150.513 140.356 1.00 49.28  ? 525 THR B CG2 1 
ATOM   5537 N N   . LEU B 1 526 ? 110.277 146.219 138.722 1.00 45.25  ? 526 LEU B N   1 
ATOM   5538 C CA  . LEU B 1 526 ? 110.825 144.972 138.198 1.00 41.42  ? 526 LEU B CA  1 
ATOM   5539 C C   . LEU B 1 526 ? 110.279 144.665 136.810 1.00 44.97  ? 526 LEU B C   1 
ATOM   5540 O O   . LEU B 1 526 ? 111.034 144.289 135.905 1.00 48.98  ? 526 LEU B O   1 
ATOM   5541 C CB  . LEU B 1 526 ? 110.516 143.831 139.163 1.00 42.38  ? 526 LEU B CB  1 
ATOM   5542 C CG  . LEU B 1 526 ? 110.954 142.436 138.727 1.00 44.62  ? 526 LEU B CG  1 
ATOM   5543 C CD1 . LEU B 1 526 ? 112.452 142.406 138.507 1.00 44.80  ? 526 LEU B CD1 1 
ATOM   5544 C CD2 . LEU B 1 526 ? 110.535 141.413 139.764 1.00 46.94  ? 526 LEU B CD2 1 
ATOM   5545 N N   . ILE B 1 527 ? 108.968 144.820 136.620 1.00 44.80  ? 527 ILE B N   1 
ATOM   5546 C CA  . ILE B 1 527 ? 108.368 144.549 135.320 1.00 42.82  ? 527 ILE B CA  1 
ATOM   5547 C C   . ILE B 1 527 ? 108.860 145.552 134.288 1.00 46.49  ? 527 ILE B C   1 
ATOM   5548 O O   . ILE B 1 527 ? 109.085 145.201 133.124 1.00 50.57  ? 527 ILE B O   1 
ATOM   5549 C CB  . ILE B 1 527 ? 106.833 144.544 135.433 1.00 34.27  ? 527 ILE B CB  1 
ATOM   5550 C CG1 . ILE B 1 527 ? 106.374 143.379 136.308 1.00 38.87  ? 527 ILE B CG1 1 
ATOM   5551 C CG2 . ILE B 1 527 ? 106.193 144.450 134.061 1.00 31.65  ? 527 ILE B CG2 1 
ATOM   5552 C CD1 . ILE B 1 527 ? 104.891 143.363 136.571 1.00 40.58  ? 527 ILE B CD1 1 
ATOM   5553 N N   . TRP B 1 528 ? 109.049 146.813 134.689 1.00 43.57  ? 528 TRP B N   1 
ATOM   5554 C CA  . TRP B 1 528 ? 109.594 147.789 133.752 1.00 41.21  ? 528 TRP B CA  1 
ATOM   5555 C C   . TRP B 1 528 ? 111.024 147.442 133.358 1.00 48.52  ? 528 TRP B C   1 
ATOM   5556 O O   . TRP B 1 528 ? 111.402 147.590 132.191 1.00 55.72  ? 528 TRP B O   1 
ATOM   5557 C CB  . TRP B 1 528 ? 109.528 149.191 134.348 1.00 47.61  ? 528 TRP B CB  1 
ATOM   5558 C CG  . TRP B 1 528 ? 109.648 150.256 133.311 1.00 48.14  ? 528 TRP B CG  1 
ATOM   5559 C CD1 . TRP B 1 528 ? 110.788 150.871 132.896 1.00 46.69  ? 528 TRP B CD1 1 
ATOM   5560 C CD2 . TRP B 1 528 ? 108.584 150.818 132.541 1.00 47.58  ? 528 TRP B CD2 1 
ATOM   5561 N NE1 . TRP B 1 528 ? 110.500 151.789 131.917 1.00 50.76  ? 528 TRP B NE1 1 
ATOM   5562 C CE2 . TRP B 1 528 ? 109.151 151.773 131.681 1.00 52.96  ? 528 TRP B CE2 1 
ATOM   5563 C CE3 . TRP B 1 528 ? 107.205 150.605 132.497 1.00 49.11  ? 528 TRP B CE3 1 
ATOM   5564 C CZ2 . TRP B 1 528 ? 108.388 152.516 130.788 1.00 53.50  ? 528 TRP B CZ2 1 
ATOM   5565 C CZ3 . TRP B 1 528 ? 106.452 151.341 131.610 1.00 52.64  ? 528 TRP B CZ3 1 
ATOM   5566 C CH2 . TRP B 1 528 ? 107.042 152.286 130.770 1.00 55.08  ? 528 TRP B CH2 1 
ATOM   5567 N N   . ASP B 1 529 ? 111.838 146.991 134.317 1.00 48.33  ? 529 ASP B N   1 
ATOM   5568 C CA  . ASP B 1 529 ? 113.205 146.587 133.999 1.00 44.92  ? 529 ASP B CA  1 
ATOM   5569 C C   . ASP B 1 529 ? 113.217 145.408 133.039 1.00 46.38  ? 529 ASP B C   1 
ATOM   5570 O O   . ASP B 1 529 ? 113.976 145.392 132.064 1.00 48.52  ? 529 ASP B O   1 
ATOM   5571 C CB  . ASP B 1 529 ? 113.967 146.229 135.276 1.00 40.21  ? 529 ASP B CB  1 
ATOM   5572 C CG  . ASP B 1 529 ? 114.229 147.426 136.159 1.00 50.82  ? 529 ASP B CG  1 
ATOM   5573 O OD1 . ASP B 1 529 ? 114.180 148.567 135.655 1.00 59.05  ? 529 ASP B OD1 1 
ATOM   5574 O OD2 . ASP B 1 529 ? 114.490 147.224 137.362 1.00 48.30  ? 529 ASP B OD2 1 
ATOM   5575 N N   . LEU B 1 530 ? 112.375 144.406 133.299 1.00 48.31  ? 530 LEU B N   1 
ATOM   5576 C CA  . LEU B 1 530 ? 112.430 143.182 132.506 1.00 47.23  ? 530 LEU B CA  1 
ATOM   5577 C C   . LEU B 1 530 ? 111.837 143.380 131.116 1.00 52.56  ? 530 LEU B C   1 
ATOM   5578 O O   . LEU B 1 530 ? 112.396 142.894 130.127 1.00 58.21  ? 530 LEU B O   1 
ATOM   5579 C CB  . LEU B 1 530 ? 111.716 142.050 133.239 1.00 42.56  ? 530 LEU B CB  1 
ATOM   5580 C CG  . LEU B 1 530 ? 112.320 141.652 134.585 1.00 45.17  ? 530 LEU B CG  1 
ATOM   5581 C CD1 . LEU B 1 530 ? 111.597 140.448 135.162 1.00 51.72  ? 530 LEU B CD1 1 
ATOM   5582 C CD2 . LEU B 1 530 ? 113.807 141.379 134.449 1.00 39.87  ? 530 LEU B CD2 1 
ATOM   5583 N N   . LYS B 1 531 ? 110.716 144.090 131.014 1.00 51.36  ? 531 LYS B N   1 
ATOM   5584 C CA  . LYS B 1 531 ? 109.992 144.211 129.754 1.00 53.02  ? 531 LYS B CA  1 
ATOM   5585 C C   . LYS B 1 531 ? 110.373 145.441 128.945 1.00 54.17  ? 531 LYS B C   1 
ATOM   5586 O O   . LYS B 1 531 ? 110.479 145.357 127.719 1.00 57.87  ? 531 LYS B O   1 
ATOM   5587 C CB  . LYS B 1 531 ? 108.483 144.231 130.014 1.00 54.32  ? 531 LYS B CB  1 
ATOM   5588 C CG  . LYS B 1 531 ? 107.865 142.860 130.209 1.00 55.49  ? 531 LYS B CG  1 
ATOM   5589 C CD  . LYS B 1 531 ? 107.877 142.067 128.914 1.00 62.92  ? 531 LYS B CD  1 
ATOM   5590 C CE  . LYS B 1 531 ? 107.106 142.790 127.822 1.00 70.28  ? 531 LYS B CE  1 
ATOM   5591 N NZ  . LYS B 1 531 ? 107.103 142.034 126.539 1.00 73.08  ? 531 LYS B NZ  1 
ATOM   5592 N N   . MET B 1 532 ? 110.578 146.584 129.592 1.00 52.78  ? 532 MET B N   1 
ATOM   5593 C CA  . MET B 1 532 ? 110.783 147.847 128.894 1.00 52.15  ? 532 MET B CA  1 
ATOM   5594 C C   . MET B 1 532 ? 112.232 148.300 128.853 1.00 50.93  ? 532 MET B C   1 
ATOM   5595 O O   . MET B 1 532 ? 112.716 148.692 127.791 1.00 53.16  ? 532 MET B O   1 
ATOM   5596 C CB  . MET B 1 532 ? 109.931 148.945 129.538 1.00 56.17  ? 532 MET B CB  1 
ATOM   5597 C CG  . MET B 1 532 ? 108.435 148.729 129.405 1.00 60.33  ? 532 MET B CG  1 
ATOM   5598 S SD  . MET B 1 532 ? 107.901 148.727 127.688 1.00 76.33  ? 532 MET B SD  1 
ATOM   5599 C CE  . MET B 1 532 ? 108.488 150.331 127.156 1.00 60.82  ? 532 MET B CE  1 
ATOM   5600 N N   . ASP B 1 533 ? 112.938 148.269 129.983 1.00 47.65  ? 533 ASP B N   1 
ATOM   5601 C CA  . ASP B 1 533 ? 114.344 148.659 129.986 1.00 42.70  ? 533 ASP B CA  1 
ATOM   5602 C C   . ASP B 1 533 ? 115.191 147.647 129.227 1.00 47.24  ? 533 ASP B C   1 
ATOM   5603 O O   . ASP B 1 533 ? 115.844 147.982 128.233 1.00 44.64  ? 533 ASP B O   1 
ATOM   5604 C CB  . ASP B 1 533 ? 114.846 148.807 131.423 1.00 40.93  ? 533 ASP B CB  1 
ATOM   5605 C CG  . ASP B 1 533 ? 114.475 150.136 132.038 1.00 51.88  ? 533 ASP B CG  1 
ATOM   5606 O OD1 . ASP B 1 533 ? 114.376 151.132 131.292 1.00 59.78  ? 533 ASP B OD1 1 
ATOM   5607 O OD2 . ASP B 1 533 ? 114.286 150.189 133.270 1.00 54.64  ? 533 ASP B OD2 1 
ATOM   5608 N N   . TRP B 1 534 ? 115.183 146.394 129.681 1.00 49.27  ? 534 TRP B N   1 
ATOM   5609 C CA  . TRP B 1 534 ? 116.010 145.361 129.075 1.00 39.88  ? 534 TRP B CA  1 
ATOM   5610 C C   . TRP B 1 534 ? 115.394 144.780 127.813 1.00 49.72  ? 534 TRP B C   1 
ATOM   5611 O O   . TRP B 1 534 ? 116.128 144.272 126.961 1.00 55.88  ? 534 TRP B O   1 
ATOM   5612 C CB  . TRP B 1 534 ? 116.273 144.246 130.086 1.00 34.26  ? 534 TRP B CB  1 
ATOM   5613 C CG  . TRP B 1 534 ? 117.027 144.707 131.294 1.00 39.52  ? 534 TRP B CG  1 
ATOM   5614 C CD1 . TRP B 1 534 ? 117.506 145.960 131.531 1.00 39.34  ? 534 TRP B CD1 1 
ATOM   5615 C CD2 . TRP B 1 534 ? 117.394 143.918 132.429 1.00 39.12  ? 534 TRP B CD2 1 
ATOM   5616 N NE1 . TRP B 1 534 ? 118.144 146.002 132.741 1.00 36.87  ? 534 TRP B NE1 1 
ATOM   5617 C CE2 . TRP B 1 534 ? 118.091 144.759 133.313 1.00 34.87  ? 534 TRP B CE2 1 
ATOM   5618 C CE3 . TRP B 1 534 ? 117.200 142.582 132.783 1.00 37.22  ? 534 TRP B CE3 1 
ATOM   5619 C CZ2 . TRP B 1 534 ? 118.595 144.310 134.525 1.00 38.85  ? 534 TRP B CZ2 1 
ATOM   5620 C CZ3 . TRP B 1 534 ? 117.699 142.139 133.985 1.00 40.37  ? 534 TRP B CZ3 1 
ATOM   5621 C CH2 . TRP B 1 534 ? 118.390 142.999 134.842 1.00 44.49  ? 534 TRP B CH2 1 
ATOM   5622 N N   . GLY B 1 535 ? 114.074 144.846 127.670 1.00 52.19  ? 535 GLY B N   1 
ATOM   5623 C CA  . GLY B 1 535 ? 113.417 144.330 126.490 1.00 50.06  ? 535 GLY B CA  1 
ATOM   5624 C C   . GLY B 1 535 ? 113.200 142.836 126.477 1.00 56.27  ? 535 GLY B C   1 
ATOM   5625 O O   . GLY B 1 535 ? 112.794 142.297 125.443 1.00 70.85  ? 535 GLY B O   1 
ATOM   5626 N N   . LEU B 1 536 ? 113.444 142.153 127.592 1.00 50.67  ? 536 LEU B N   1 
ATOM   5627 C CA  . LEU B 1 536 ? 113.337 140.705 127.639 1.00 49.46  ? 536 LEU B CA  1 
ATOM   5628 C C   . LEU B 1 536 ? 111.875 140.275 127.530 1.00 57.01  ? 536 LEU B C   1 
ATOM   5629 O O   . LEU B 1 536 ? 110.959 141.094 127.422 1.00 62.33  ? 536 LEU B O   1 
ATOM   5630 C CB  . LEU B 1 536 ? 113.960 140.172 128.926 1.00 52.25  ? 536 LEU B CB  1 
ATOM   5631 C CG  . LEU B 1 536 ? 115.383 140.619 129.257 1.00 50.94  ? 536 LEU B CG  1 
ATOM   5632 C CD1 . LEU B 1 536 ? 115.739 140.199 130.660 1.00 45.72  ? 536 LEU B CD1 1 
ATOM   5633 C CD2 . LEU B 1 536 ? 116.376 140.047 128.273 1.00 48.59  ? 536 LEU B CD2 1 
ATOM   5634 N N   . PHE B 1 537 ? 111.664 138.958 127.560 1.00 58.49  ? 537 PHE B N   1 
ATOM   5635 C CA  . PHE B 1 537 ? 110.328 138.364 127.498 1.00 60.32  ? 537 PHE B CA  1 
ATOM   5636 C C   . PHE B 1 537 ? 109.579 138.816 126.248 1.00 72.65  ? 537 PHE B C   1 
ATOM   5637 O O   . PHE B 1 537 ? 108.376 139.079 126.282 1.00 78.10  ? 537 PHE B O   1 
ATOM   5638 C CB  . PHE B 1 537 ? 109.526 138.678 128.762 1.00 55.51  ? 537 PHE B CB  1 
ATOM   5639 C CG  . PHE B 1 537 ? 110.139 138.129 130.016 1.00 60.71  ? 537 PHE B CG  1 
ATOM   5640 C CD1 . PHE B 1 537 ? 111.128 138.828 130.683 1.00 61.22  ? 537 PHE B CD1 1 
ATOM   5641 C CD2 . PHE B 1 537 ? 109.726 136.913 130.528 1.00 64.20  ? 537 PHE B CD2 1 
ATOM   5642 C CE1 . PHE B 1 537 ? 111.694 138.324 131.835 1.00 59.26  ? 537 PHE B CE1 1 
ATOM   5643 C CE2 . PHE B 1 537 ? 110.288 136.405 131.682 1.00 62.36  ? 537 PHE B CE2 1 
ATOM   5644 C CZ  . PHE B 1 537 ? 111.273 137.111 132.336 1.00 59.97  ? 537 PHE B CZ  1 
ATOM   5645 N N   . ASP B 1 538 ? 110.299 138.909 125.135 1.00 74.02  ? 538 ASP B N   1 
ATOM   5646 C CA  . ASP B 1 538 ? 109.713 139.303 123.864 1.00 79.19  ? 538 ASP B CA  1 
ATOM   5647 C C   . ASP B 1 538 ? 109.303 138.059 123.090 1.00 88.84  ? 538 ASP B C   1 
ATOM   5648 O O   . ASP B 1 538 ? 110.117 137.155 122.881 1.00 91.05  ? 538 ASP B O   1 
ATOM   5649 C CB  . ASP B 1 538 ? 110.704 140.134 123.050 1.00 77.32  ? 538 ASP B CB  1 
ATOM   5650 C CG  . ASP B 1 538 ? 110.075 140.746 121.815 1.00 89.52  ? 538 ASP B CG  1 
ATOM   5651 O OD1 . ASP B 1 538 ? 108.833 140.705 121.693 1.00 90.66  ? 538 ASP B OD1 1 
ATOM   5652 O OD2 . ASP B 1 538 ? 110.825 141.268 120.963 1.00 90.00  ? 538 ASP B OD2 1 
ATOM   5653 N N   . LYS B 1 539 ? 108.040 138.015 122.669 1.00 95.20  ? 539 LYS B N   1 
ATOM   5654 C CA  . LYS B 1 539 ? 107.531 136.865 121.935 1.00 99.62  ? 539 LYS B CA  1 
ATOM   5655 C C   . LYS B 1 539 ? 108.048 136.793 120.506 1.00 95.14  ? 539 LYS B C   1 
ATOM   5656 O O   . LYS B 1 539 ? 107.895 135.750 119.863 1.00 92.85  ? 539 LYS B O   1 
ATOM   5657 C CB  . LYS B 1 539 ? 106.001 136.877 121.933 1.00 105.90 ? 539 LYS B CB  1 
ATOM   5658 C CG  . LYS B 1 539 ? 105.390 136.687 123.311 1.00 109.31 ? 539 LYS B CG  1 
ATOM   5659 C CD  . LYS B 1 539 ? 105.948 135.443 123.987 1.00 106.95 ? 539 LYS B CD  1 
ATOM   5660 C CE  . LYS B 1 539 ? 105.429 135.302 125.408 1.00 112.02 ? 539 LYS B CE  1 
ATOM   5661 N NZ  . LYS B 1 539 ? 105.995 134.104 126.088 1.00 110.67 ? 539 LYS B NZ  1 
ATOM   5662 N N   . ASN B 1 540 ? 108.656 137.863 119.997 1.00 95.91  ? 540 ASN B N   1 
ATOM   5663 C CA  . ASN B 1 540 ? 109.281 137.848 118.682 1.00 98.17  ? 540 ASN B CA  1 
ATOM   5664 C C   . ASN B 1 540 ? 110.678 137.246 118.703 1.00 97.73  ? 540 ASN B C   1 
ATOM   5665 O O   . ASN B 1 540 ? 111.442 137.444 117.751 1.00 95.98  ? 540 ASN B O   1 
ATOM   5666 C CB  . ASN B 1 540 ? 109.332 139.265 118.104 1.00 100.72 ? 540 ASN B CB  1 
ATOM   5667 C CG  . ASN B 1 540 ? 107.964 139.780 117.700 1.00 108.32 ? 540 ASN B CG  1 
ATOM   5668 O OD1 . ASN B 1 540 ? 107.480 139.494 116.604 1.00 111.77 ? 540 ASN B OD1 1 
ATOM   5669 N ND2 . ASN B 1 540 ? 107.334 140.546 118.583 1.00 108.78 ? 540 ASN B ND2 1 
ATOM   5670 N N   . ALA B 1 541 ? 111.028 136.523 119.762 1.00 96.19  ? 541 ALA B N   1 
ATOM   5671 C CA  . ALA B 1 541 ? 112.348 135.923 119.886 1.00 93.23  ? 541 ALA B CA  1 
ATOM   5672 C C   . ALA B 1 541 ? 112.361 134.559 119.202 1.00 106.03 ? 541 ALA B C   1 
ATOM   5673 O O   . ALA B 1 541 ? 111.373 134.121 118.605 1.00 110.08 ? 541 ALA B O   1 
ATOM   5674 C CB  . ALA B 1 541 ? 112.745 135.825 121.355 1.00 82.91  ? 541 ALA B CB  1 
ATOM   5675 N N   . GLY B 1 542 ? 113.494 133.868 119.286 1.00 106.93 ? 542 GLY B N   1 
ATOM   5676 C CA  . GLY B 1 542 ? 113.621 132.537 118.730 1.00 107.27 ? 542 GLY B CA  1 
ATOM   5677 C C   . GLY B 1 542 ? 113.936 131.503 119.790 1.00 101.26 ? 542 GLY B C   1 
ATOM   5678 O O   . GLY B 1 542 ? 113.127 131.260 120.691 1.00 97.53  ? 542 GLY B O   1 
ATOM   5679 N N   . GLU B 1 543 ? 115.115 130.886 119.693 1.00 102.11 ? 543 GLU B N   1 
ATOM   5680 C CA  . GLU B 1 543 ? 115.524 129.897 120.682 1.00 102.37 ? 543 GLU B CA  1 
ATOM   5681 C C   . GLU B 1 543 ? 115.865 130.525 122.026 1.00 102.14 ? 543 GLU B C   1 
ATOM   5682 O O   . GLU B 1 543 ? 115.968 129.802 123.022 1.00 99.97  ? 543 GLU B O   1 
ATOM   5683 C CB  . GLU B 1 543 ? 116.723 129.096 120.166 1.00 101.91 ? 543 GLU B CB  1 
ATOM   5684 C CG  . GLU B 1 543 ? 118.007 129.901 120.011 1.00 106.12 ? 543 GLU B CG  1 
ATOM   5685 C CD  . GLU B 1 543 ? 118.015 130.773 118.770 1.00 110.14 ? 543 GLU B CD  1 
ATOM   5686 O OE1 . GLU B 1 543 ? 117.117 130.609 117.918 1.00 113.60 ? 543 GLU B OE1 1 
ATOM   5687 O OE2 . GLU B 1 543 ? 118.921 131.624 118.646 1.00 106.22 ? 543 GLU B OE2 1 
ATOM   5688 N N   . ASN B 1 544 ? 116.037 131.844 122.081 1.00 100.67 ? 544 ASN B N   1 
ATOM   5689 C CA  . ASN B 1 544 ? 116.375 132.533 123.324 1.00 89.40  ? 544 ASN B CA  1 
ATOM   5690 C C   . ASN B 1 544 ? 115.149 132.545 124.226 1.00 84.63  ? 544 ASN B C   1 
ATOM   5691 O O   . ASN B 1 544 ? 114.281 133.412 124.105 1.00 83.52  ? 544 ASN B O   1 
ATOM   5692 C CB  . ASN B 1 544 ? 116.856 133.950 123.035 1.00 82.80  ? 544 ASN B CB  1 
ATOM   5693 C CG  . ASN B 1 544 ? 118.012 133.985 122.059 1.00 86.46  ? 544 ASN B CG  1 
ATOM   5694 O OD1 . ASN B 1 544 ? 118.851 133.088 122.041 1.00 92.26  ? 544 ASN B OD1 1 
ATOM   5695 N ND2 . ASN B 1 544 ? 118.062 135.027 121.240 1.00 83.08  ? 544 ASN B ND2 1 
ATOM   5696 N N   . THR B 1 545 ? 115.071 131.576 125.134 1.00 85.06  ? 545 THR B N   1 
ATOM   5697 C CA  . THR B 1 545 ? 113.917 131.460 126.016 1.00 85.50  ? 545 THR B CA  1 
ATOM   5698 C C   . THR B 1 545 ? 113.874 132.644 126.972 1.00 81.58  ? 545 THR B C   1 
ATOM   5699 O O   . THR B 1 545 ? 114.857 132.928 127.663 1.00 77.93  ? 545 THR B O   1 
ATOM   5700 C CB  . THR B 1 545 ? 113.975 130.148 126.794 1.00 86.51  ? 545 THR B CB  1 
ATOM   5701 O OG1 . THR B 1 545 ? 113.974 129.047 125.877 1.00 95.18  ? 545 THR B OG1 1 
ATOM   5702 C CG2 . THR B 1 545 ? 112.778 130.026 127.720 1.00 79.55  ? 545 THR B CG2 1 
ATOM   5703 N N   . PHE B 1 546 ? 112.738 133.341 126.997 1.00 78.60  ? 546 PHE B N   1 
ATOM   5704 C CA  . PHE B 1 546 ? 112.446 134.482 127.861 1.00 72.77  ? 546 PHE B CA  1 
ATOM   5705 C C   . PHE B 1 546 ? 113.275 135.714 127.517 1.00 69.76  ? 546 PHE B C   1 
ATOM   5706 O O   . PHE B 1 546 ? 113.120 136.745 128.177 1.00 70.63  ? 546 PHE B O   1 
ATOM   5707 C CB  . PHE B 1 546 ? 112.640 134.153 129.349 1.00 76.53  ? 546 PHE B CB  1 
ATOM   5708 C CG  . PHE B 1 546 ? 111.865 132.952 129.814 1.00 86.32  ? 546 PHE B CG  1 
ATOM   5709 C CD1 . PHE B 1 546 ? 110.654 132.620 129.231 1.00 89.11  ? 546 PHE B CD1 1 
ATOM   5710 C CD2 . PHE B 1 546 ? 112.350 132.153 130.836 1.00 85.42  ? 546 PHE B CD2 1 
ATOM   5711 C CE1 . PHE B 1 546 ? 109.943 131.516 129.658 1.00 87.74  ? 546 PHE B CE1 1 
ATOM   5712 C CE2 . PHE B 1 546 ? 111.644 131.048 131.267 1.00 83.20  ? 546 PHE B CE2 1 
ATOM   5713 C CZ  . PHE B 1 546 ? 110.440 130.729 130.677 1.00 85.23  ? 546 PHE B CZ  1 
ATOM   5714 N N   . LEU B 1 547 ? 114.144 135.645 126.518 1.00 71.27  ? 547 LEU B N   1 
ATOM   5715 C CA  . LEU B 1 547 ? 114.998 136.753 126.129 1.00 62.63  ? 547 LEU B CA  1 
ATOM   5716 C C   . LEU B 1 547 ? 114.522 137.317 124.792 1.00 63.80  ? 547 LEU B C   1 
ATOM   5717 O O   . LEU B 1 547 ? 113.457 136.957 124.286 1.00 75.93  ? 547 LEU B O   1 
ATOM   5718 C CB  . LEU B 1 547 ? 116.455 136.291 126.084 1.00 62.18  ? 547 LEU B CB  1 
ATOM   5719 C CG  . LEU B 1 547 ? 116.900 135.524 127.331 1.00 64.70  ? 547 LEU B CG  1 
ATOM   5720 C CD1 . LEU B 1 547 ? 118.359 135.122 127.243 1.00 56.29  ? 547 LEU B CD1 1 
ATOM   5721 C CD2 . LEU B 1 547 ? 116.638 136.335 128.589 1.00 59.83  ? 547 LEU B CD2 1 
ATOM   5722 N N   . ARG B 1 548 ? 115.304 138.226 124.218 1.00 62.09  ? 548 ARG B N   1 
ATOM   5723 C CA  . ARG B 1 548 ? 114.952 138.846 122.952 1.00 70.45  ? 548 ARG B CA  1 
ATOM   5724 C C   . ARG B 1 548 ? 115.455 137.999 121.784 1.00 70.62  ? 548 ARG B C   1 
ATOM   5725 O O   . ARG B 1 548 ? 116.142 136.991 121.959 1.00 74.56  ? 548 ARG B O   1 
ATOM   5726 C CB  . ARG B 1 548 ? 115.514 140.264 122.871 1.00 71.48  ? 548 ARG B CB  1 
ATOM   5727 C CG  . ARG B 1 548 ? 115.406 141.051 124.158 1.00 59.75  ? 548 ARG B CG  1 
ATOM   5728 C CD  . ARG B 1 548 ? 116.723 141.045 124.901 1.00 57.86  ? 548 ARG B CD  1 
ATOM   5729 N NE  . ARG B 1 548 ? 117.777 141.656 124.105 1.00 61.45  ? 548 ARG B NE  1 
ATOM   5730 C CZ  . ARG B 1 548 ? 118.138 142.926 124.199 1.00 58.29  ? 548 ARG B CZ  1 
ATOM   5731 N NH1 . ARG B 1 548 ? 117.575 143.739 125.077 1.00 57.00  ? 548 ARG B NH1 1 
ATOM   5732 N NH2 . ARG B 1 548 ? 119.085 143.391 123.393 1.00 62.15  ? 548 ARG B NH2 1 
ATOM   5733 N N   . GLU B 1 549 ? 115.102 138.421 120.568 1.00 76.43  ? 549 GLU B N   1 
ATOM   5734 C CA  . GLU B 1 549 ? 115.513 137.687 119.375 1.00 84.59  ? 549 GLU B CA  1 
ATOM   5735 C C   . GLU B 1 549 ? 117.020 137.765 119.167 1.00 81.11  ? 549 GLU B C   1 
ATOM   5736 O O   . GLU B 1 549 ? 117.675 136.747 118.917 1.00 77.25  ? 549 GLU B O   1 
ATOM   5737 C CB  . GLU B 1 549 ? 114.774 138.226 118.151 1.00 88.15  ? 549 GLU B CB  1 
ATOM   5738 C CG  . GLU B 1 549 ? 115.233 137.619 116.837 1.00 92.36  ? 549 GLU B CG  1 
ATOM   5739 C CD  . GLU B 1 549 ? 114.466 138.161 115.648 1.00 103.45 ? 549 GLU B CD  1 
ATOM   5740 O OE1 . GLU B 1 549 ? 113.457 138.864 115.862 1.00 102.58 ? 549 GLU B OE1 1 
ATOM   5741 O OE2 . GLU B 1 549 ? 114.874 137.885 114.500 1.00 106.93 ? 549 GLU B OE2 1 
ATOM   5742 N N   . GLU B 1 550 ? 117.586 138.962 119.267 1.00 83.37  ? 550 GLU B N   1 
ATOM   5743 C CA  . GLU B 1 550 ? 119.009 139.181 119.054 1.00 78.25  ? 550 GLU B CA  1 
ATOM   5744 C C   . GLU B 1 550 ? 119.681 139.555 120.368 1.00 69.83  ? 550 GLU B C   1 
ATOM   5745 O O   . GLU B 1 550 ? 119.165 140.376 121.132 1.00 66.78  ? 550 GLU B O   1 
ATOM   5746 C CB  . GLU B 1 550 ? 119.244 140.269 118.005 1.00 75.99  ? 550 GLU B CB  1 
ATOM   5747 C CG  . GLU B 1 550 ? 118.207 141.378 118.013 1.00 82.52  ? 550 GLU B CG  1 
ATOM   5748 C CD  . GLU B 1 550 ? 118.426 142.384 116.899 1.00 90.04  ? 550 GLU B CD  1 
ATOM   5749 O OE1 . GLU B 1 550 ? 119.381 142.203 116.116 1.00 88.10  ? 550 GLU B OE1 1 
ATOM   5750 O OE2 . GLU B 1 550 ? 117.644 143.353 116.808 1.00 90.65  ? 550 GLU B OE2 1 
ATOM   5751 N N   . ILE B 1 551 ? 120.832 138.940 120.624 1.00 68.40  ? 551 ILE B N   1 
ATOM   5752 C CA  . ILE B 1 551 ? 121.568 139.098 121.870 1.00 63.84  ? 551 ILE B CA  1 
ATOM   5753 C C   . ILE B 1 551 ? 123.028 139.364 121.533 1.00 65.84  ? 551 ILE B C   1 
ATOM   5754 O O   . ILE B 1 551 ? 123.613 138.661 120.702 1.00 72.56  ? 551 ILE B O   1 
ATOM   5755 C CB  . ILE B 1 551 ? 121.428 137.851 122.763 1.00 60.43  ? 551 ILE B CB  1 
ATOM   5756 C CG1 . ILE B 1 551 ? 120.175 137.958 123.629 1.00 60.03  ? 551 ILE B CG1 1 
ATOM   5757 C CG2 . ILE B 1 551 ? 122.668 137.634 123.611 1.00 64.80  ? 551 ILE B CG2 1 
ATOM   5758 C CD1 . ILE B 1 551 ? 120.004 136.801 124.571 1.00 64.13  ? 551 ILE B CD1 1 
ATOM   5759 N N   . VAL B 1 552 ? 123.613 140.378 122.170 1.00 59.26  ? 552 VAL B N   1 
ATOM   5760 C CA  . VAL B 1 552 ? 124.998 140.741 121.900 1.00 61.15  ? 552 VAL B CA  1 
ATOM   5761 C C   . VAL B 1 552 ? 125.967 140.219 122.957 1.00 61.78  ? 552 VAL B C   1 
ATOM   5762 O O   . VAL B 1 552 ? 127.178 140.170 122.696 1.00 65.57  ? 552 VAL B O   1 
ATOM   5763 C CB  . VAL B 1 552 ? 125.151 142.270 121.753 1.00 63.48  ? 552 VAL B CB  1 
ATOM   5764 C CG1 . VAL B 1 552 ? 124.028 142.837 120.900 1.00 61.56  ? 552 VAL B CG1 1 
ATOM   5765 C CG2 . VAL B 1 552 ? 125.190 142.938 123.112 1.00 52.56  ? 552 VAL B CG2 1 
ATOM   5766 N N   . TYR B 1 553 ? 125.486 139.833 124.115 1.00 60.86  ? 553 TYR B N   1 
ATOM   5767 C CA  . TYR B 1 553 ? 126.445 139.349 125.094 1.00 61.76  ? 553 TYR B CA  1 
ATOM   5768 C C   . TYR B 1 553 ? 126.701 137.856 124.901 1.00 69.90  ? 553 TYR B C   1 
ATOM   5769 O O   . TYR B 1 553 ? 125.792 137.108 124.529 1.00 71.03  ? 553 TYR B O   1 
ATOM   5770 C CB  . TYR B 1 553 ? 125.943 139.631 126.506 1.00 52.37  ? 553 TYR B CB  1 
ATOM   5771 C CG  . TYR B 1 553 ? 125.867 141.115 126.793 1.00 44.75  ? 553 TYR B CG  1 
ATOM   5772 C CD1 . TYR B 1 553 ? 126.916 141.955 126.455 1.00 45.96  ? 553 TYR B CD1 1 
ATOM   5773 C CD2 . TYR B 1 553 ? 124.738 141.680 127.367 1.00 39.46  ? 553 TYR B CD2 1 
ATOM   5774 C CE1 . TYR B 1 553 ? 126.854 143.310 126.699 1.00 43.67  ? 553 TYR B CE1 1 
ATOM   5775 C CE2 . TYR B 1 553 ? 124.668 143.036 127.612 1.00 39.66  ? 553 TYR B CE2 1 
ATOM   5776 C CZ  . TYR B 1 553 ? 125.730 143.846 127.276 1.00 42.96  ? 553 TYR B CZ  1 
ATOM   5777 O OH  . TYR B 1 553 ? 125.675 145.199 127.513 1.00 37.95  ? 553 TYR B OH  1 
ATOM   5778 N N   . PRO B 1 554 ? 127.940 137.416 125.146 1.00 68.70  ? 554 PRO B N   1 
ATOM   5779 C CA  . PRO B 1 554 ? 128.351 136.079 124.677 1.00 67.60  ? 554 PRO B CA  1 
ATOM   5780 C C   . PRO B 1 554 ? 127.509 134.930 125.206 1.00 70.87  ? 554 PRO B C   1 
ATOM   5781 O O   . PRO B 1 554 ? 127.262 133.968 124.469 1.00 69.77  ? 554 PRO B O   1 
ATOM   5782 C CB  . PRO B 1 554 ? 129.803 135.979 125.166 1.00 68.60  ? 554 PRO B CB  1 
ATOM   5783 C CG  . PRO B 1 554 ? 130.255 137.389 125.292 1.00 67.55  ? 554 PRO B CG  1 
ATOM   5784 C CD  . PRO B 1 554 ? 129.057 138.149 125.763 1.00 63.88  ? 554 PRO B CD  1 
ATOM   5785 N N   . GLN B 1 555 ? 127.060 134.995 126.453 1.00 68.75  ? 555 GLN B N   1 
ATOM   5786 C CA  . GLN B 1 555 ? 126.384 133.876 127.092 1.00 66.60  ? 555 GLN B CA  1 
ATOM   5787 C C   . GLN B 1 555 ? 124.934 134.227 127.390 1.00 66.43  ? 555 GLN B C   1 
ATOM   5788 O O   . GLN B 1 555 ? 124.625 135.354 127.785 1.00 72.12  ? 555 GLN B O   1 
ATOM   5789 C CB  . GLN B 1 555 ? 127.097 133.476 128.386 1.00 65.95  ? 555 GLN B CB  1 
ATOM   5790 C CG  . GLN B 1 555 ? 128.557 133.110 128.196 1.00 73.15  ? 555 GLN B CG  1 
ATOM   5791 C CD  . GLN B 1 555 ? 128.744 131.928 127.270 1.00 76.32  ? 555 GLN B CD  1 
ATOM   5792 O OE1 . GLN B 1 555 ? 127.922 131.013 127.239 1.00 78.87  ? 555 GLN B OE1 1 
ATOM   5793 N NE2 . GLN B 1 555 ? 129.828 131.942 126.505 1.00 71.21  ? 555 GLN B NE2 1 
ATOM   5794 N N   . LYS B 1 556 ? 124.045 133.253 127.190 1.00 64.04  ? 556 LYS B N   1 
ATOM   5795 C CA  . LYS B 1 556 ? 122.654 133.434 127.580 1.00 61.34  ? 556 LYS B CA  1 
ATOM   5796 C C   . LYS B 1 556 ? 122.465 133.277 129.082 1.00 62.72  ? 556 LYS B C   1 
ATOM   5797 O O   . LYS B 1 556 ? 121.453 133.731 129.625 1.00 65.34  ? 556 LYS B O   1 
ATOM   5798 C CB  . LYS B 1 556 ? 121.763 132.441 126.835 1.00 66.02  ? 556 LYS B CB  1 
ATOM   5799 C CG  . LYS B 1 556 ? 121.947 132.459 125.330 1.00 75.41  ? 556 LYS B CG  1 
ATOM   5800 C CD  . LYS B 1 556 ? 121.007 131.481 124.647 1.00 85.85  ? 556 LYS B CD  1 
ATOM   5801 C CE  . LYS B 1 556 ? 121.294 131.393 123.158 1.00 90.64  ? 556 LYS B CE  1 
ATOM   5802 N NZ  . LYS B 1 556 ? 120.341 130.488 122.459 1.00 88.79  ? 556 LYS B NZ  1 
ATOM   5803 N N   . ALA B 1 557 ? 123.419 132.639 129.765 1.00 62.51  ? 557 ALA B N   1 
ATOM   5804 C CA  . ALA B 1 557 ? 123.326 132.499 131.213 1.00 58.70  ? 557 ALA B CA  1 
ATOM   5805 C C   . ALA B 1 557 ? 123.471 133.841 131.914 1.00 57.60  ? 557 ALA B C   1 
ATOM   5806 O O   . ALA B 1 557 ? 122.952 134.020 133.024 1.00 54.62  ? 557 ALA B O   1 
ATOM   5807 C CB  . ALA B 1 557 ? 124.385 131.520 131.717 1.00 56.22  ? 557 ALA B CB  1 
ATOM   5808 N N   . TYR B 1 558 ? 124.170 134.788 131.283 1.00 58.01  ? 558 TYR B N   1 
ATOM   5809 C CA  . TYR B 1 558 ? 124.286 136.126 131.851 1.00 54.73  ? 558 TYR B CA  1 
ATOM   5810 C C   . TYR B 1 558 ? 122.915 136.755 132.041 1.00 57.32  ? 558 TYR B C   1 
ATOM   5811 O O   . TYR B 1 558 ? 122.648 137.379 133.071 1.00 59.26  ? 558 TYR B O   1 
ATOM   5812 C CB  . TYR B 1 558 ? 125.153 137.010 130.954 1.00 50.70  ? 558 TYR B CB  1 
ATOM   5813 C CG  . TYR B 1 558 ? 126.611 136.620 130.903 1.00 59.89  ? 558 TYR B CG  1 
ATOM   5814 C CD1 . TYR B 1 558 ? 127.200 135.909 131.938 1.00 60.83  ? 558 TYR B CD1 1 
ATOM   5815 C CD2 . TYR B 1 558 ? 127.402 136.970 129.818 1.00 63.48  ? 558 TYR B CD2 1 
ATOM   5816 C CE1 . TYR B 1 558 ? 128.532 135.555 131.891 1.00 59.57  ? 558 TYR B CE1 1 
ATOM   5817 C CE2 . TYR B 1 558 ? 128.733 136.621 129.763 1.00 61.88  ? 558 TYR B CE2 1 
ATOM   5818 C CZ  . TYR B 1 558 ? 129.294 135.913 130.802 1.00 62.87  ? 558 TYR B CZ  1 
ATOM   5819 O OH  . TYR B 1 558 ? 130.622 135.563 130.747 1.00 69.34  ? 558 TYR B OH  1 
ATOM   5820 N N   . TYR B 1 559 ? 122.024 136.580 131.065 1.00 50.37  ? 559 TYR B N   1 
ATOM   5821 C CA  . TYR B 1 559 ? 120.705 137.197 131.143 1.00 43.16  ? 559 TYR B CA  1 
ATOM   5822 C C   . TYR B 1 559 ? 119.851 136.571 132.239 1.00 49.74  ? 559 TYR B C   1 
ATOM   5823 O O   . TYR B 1 559 ? 119.119 137.278 132.935 1.00 58.45  ? 559 TYR B O   1 
ATOM   5824 C CB  . TYR B 1 559 ? 120.006 137.097 129.792 1.00 43.85  ? 559 TYR B CB  1 
ATOM   5825 C CG  . TYR B 1 559 ? 120.690 137.886 128.704 1.00 43.90  ? 559 TYR B CG  1 
ATOM   5826 C CD1 . TYR B 1 559 ? 121.826 137.398 128.077 1.00 45.35  ? 559 TYR B CD1 1 
ATOM   5827 C CD2 . TYR B 1 559 ? 120.199 139.117 128.303 1.00 40.22  ? 559 TYR B CD2 1 
ATOM   5828 C CE1 . TYR B 1 559 ? 122.454 138.113 127.087 1.00 45.48  ? 559 TYR B CE1 1 
ATOM   5829 C CE2 . TYR B 1 559 ? 120.821 139.840 127.310 1.00 44.09  ? 559 TYR B CE2 1 
ATOM   5830 C CZ  . TYR B 1 559 ? 121.948 139.333 126.705 1.00 49.80  ? 559 TYR B CZ  1 
ATOM   5831 O OH  . TYR B 1 559 ? 122.573 140.050 125.715 1.00 56.37  ? 559 TYR B OH  1 
ATOM   5832 N N   . TYR B 1 560 ? 119.924 135.250 132.410 1.00 51.83  ? 560 TYR B N   1 
ATOM   5833 C CA  . TYR B 1 560 ? 119.145 134.604 133.464 1.00 50.86  ? 560 TYR B CA  1 
ATOM   5834 C C   . TYR B 1 560 ? 119.671 134.973 134.845 1.00 53.72  ? 560 TYR B C   1 
ATOM   5835 O O   . TYR B 1 560 ? 118.887 135.239 135.770 1.00 53.19  ? 560 TYR B O   1 
ATOM   5836 C CB  . TYR B 1 560 ? 119.156 133.092 133.263 1.00 54.78  ? 560 TYR B CB  1 
ATOM   5837 C CG  . TYR B 1 560 ? 118.720 132.671 131.881 1.00 60.07  ? 560 TYR B CG  1 
ATOM   5838 C CD1 . TYR B 1 560 ? 117.631 133.270 131.267 1.00 62.55  ? 560 TYR B CD1 1 
ATOM   5839 C CD2 . TYR B 1 560 ? 119.406 131.689 131.184 1.00 58.11  ? 560 TYR B CD2 1 
ATOM   5840 C CE1 . TYR B 1 560 ? 117.231 132.894 130.002 1.00 68.59  ? 560 TYR B CE1 1 
ATOM   5841 C CE2 . TYR B 1 560 ? 119.015 131.308 129.918 1.00 61.73  ? 560 TYR B CE2 1 
ATOM   5842 C CZ  . TYR B 1 560 ? 117.926 131.913 129.331 1.00 71.05  ? 560 TYR B CZ  1 
ATOM   5843 O OH  . TYR B 1 560 ? 117.532 131.537 128.069 1.00 75.96  ? 560 TYR B OH  1 
ATOM   5844 N N   . CYS B 1 561 ? 120.998 135.004 135.003 1.00 52.47  ? 561 CYS B N   1 
ATOM   5845 C CA  . CYS B 1 561 ? 121.574 135.488 136.251 1.00 53.13  ? 561 CYS B CA  1 
ATOM   5846 C C   . CYS B 1 561 ? 121.155 136.927 136.517 1.00 58.15  ? 561 CYS B C   1 
ATOM   5847 O O   . CYS B 1 561 ? 120.845 137.294 137.657 1.00 60.70  ? 561 CYS B O   1 
ATOM   5848 C CB  . CYS B 1 561 ? 123.097 135.372 136.208 1.00 57.71  ? 561 CYS B CB  1 
ATOM   5849 S SG  . CYS B 1 561 ? 123.722 133.683 136.096 1.00 82.03  ? 561 CYS B SG  1 
ATOM   5850 N N   . ALA B 1 562 ? 121.130 137.752 135.469 1.00 53.26  ? 562 ALA B N   1 
ATOM   5851 C CA  . ALA B 1 562 ? 120.712 139.139 135.612 1.00 49.77  ? 562 ALA B CA  1 
ATOM   5852 C C   . ALA B 1 562 ? 119.257 139.240 136.036 1.00 49.33  ? 562 ALA B C   1 
ATOM   5853 O O   . ALA B 1 562 ? 118.910 140.081 136.864 1.00 54.01  ? 562 ALA B O   1 
ATOM   5854 C CB  . ALA B 1 562 ? 120.938 139.888 134.304 1.00 44.49  ? 562 ALA B CB  1 
ATOM   5855 N N   . ILE B 1 563 ? 118.389 138.398 135.475 1.00 44.75  ? 563 ILE B N   1 
ATOM   5856 C CA  . ILE B 1 563 ? 116.976 138.424 135.850 1.00 43.02  ? 563 ILE B CA  1 
ATOM   5857 C C   . ILE B 1 563 ? 116.809 138.066 137.323 1.00 49.04  ? 563 ILE B C   1 
ATOM   5858 O O   . ILE B 1 563 ? 116.093 138.747 138.072 1.00 49.01  ? 563 ILE B O   1 
ATOM   5859 C CB  . ILE B 1 563 ? 116.164 137.481 134.946 1.00 37.14  ? 563 ILE B CB  1 
ATOM   5860 C CG1 . ILE B 1 563 ? 116.098 138.030 133.524 1.00 39.49  ? 563 ILE B CG1 1 
ATOM   5861 C CG2 . ILE B 1 563 ? 114.767 137.277 135.501 1.00 40.64  ? 563 ILE B CG2 1 
ATOM   5862 C CD1 . ILE B 1 563 ? 115.358 137.133 132.567 1.00 46.40  ? 563 ILE B CD1 1 
ATOM   5863 N N   . ILE B 1 564 ? 117.478 136.997 137.763 1.00 49.25  ? 564 ILE B N   1 
ATOM   5864 C CA  . ILE B 1 564 ? 117.347 136.571 139.156 1.00 51.08  ? 564 ILE B CA  1 
ATOM   5865 C C   . ILE B 1 564 ? 117.867 137.654 140.096 1.00 50.18  ? 564 ILE B C   1 
ATOM   5866 O O   . ILE B 1 564 ? 117.197 138.043 141.068 1.00 48.51  ? 564 ILE B O   1 
ATOM   5867 C CB  . ILE B 1 564 ? 118.075 135.234 139.381 1.00 54.27  ? 564 ILE B CB  1 
ATOM   5868 C CG1 . ILE B 1 564 ? 117.485 134.145 138.484 1.00 54.03  ? 564 ILE B CG1 1 
ATOM   5869 C CG2 . ILE B 1 564 ? 117.993 134.823 140.841 1.00 53.00  ? 564 ILE B CG2 1 
ATOM   5870 C CD1 . ILE B 1 564 ? 118.198 132.818 138.593 1.00 53.93  ? 564 ILE B CD1 1 
ATOM   5871 N N   . GLU B 1 565 ? 119.071 138.163 139.816 1.00 47.72  ? 565 GLU B N   1 
ATOM   5872 C CA  . GLU B 1 565 ? 119.645 139.188 140.676 1.00 47.79  ? 565 GLU B CA  1 
ATOM   5873 C C   . GLU B 1 565 ? 118.836 140.474 140.623 1.00 51.09  ? 565 GLU B C   1 
ATOM   5874 O O   . GLU B 1 565 ? 118.761 141.190 141.623 1.00 53.70  ? 565 GLU B O   1 
ATOM   5875 C CB  . GLU B 1 565 ? 121.107 139.443 140.298 1.00 47.30  ? 565 GLU B CB  1 
ATOM   5876 C CG  . GLU B 1 565 ? 121.322 140.221 139.012 1.00 45.04  ? 565 GLU B CG  1 
ATOM   5877 C CD  . GLU B 1 565 ? 121.411 141.717 139.238 1.00 46.36  ? 565 GLU B CD  1 
ATOM   5878 O OE1 . GLU B 1 565 ? 121.832 142.127 140.337 1.00 46.92  ? 565 GLU B OE1 1 
ATOM   5879 O OE2 . GLU B 1 565 ? 121.053 142.482 138.320 1.00 46.39  ? 565 GLU B OE2 1 
ATOM   5880 N N   . ASP B 1 566 ? 118.203 140.773 139.487 1.00 48.32  ? 566 ASP B N   1 
ATOM   5881 C CA  . ASP B 1 566 ? 117.396 141.979 139.386 1.00 43.20  ? 566 ASP B CA  1 
ATOM   5882 C C   . ASP B 1 566 ? 116.147 141.870 140.238 1.00 41.17  ? 566 ASP B C   1 
ATOM   5883 O O   . ASP B 1 566 ? 115.778 142.827 140.918 1.00 46.70  ? 566 ASP B O   1 
ATOM   5884 C CB  . ASP B 1 566 ? 117.027 142.250 137.931 1.00 42.75  ? 566 ASP B CB  1 
ATOM   5885 C CG  . ASP B 1 566 ? 116.642 143.695 137.691 1.00 49.75  ? 566 ASP B CG  1 
ATOM   5886 O OD1 . ASP B 1 566 ? 117.550 144.549 137.638 1.00 48.85  ? 566 ASP B OD1 1 
ATOM   5887 O OD2 . ASP B 1 566 ? 115.434 143.978 137.555 1.00 51.66  ? 566 ASP B OD2 1 
ATOM   5888 N N   . VAL B 1 567 ? 115.491 140.708 140.235 1.00 42.47  ? 567 VAL B N   1 
ATOM   5889 C CA  . VAL B 1 567 ? 114.342 140.522 141.121 1.00 45.91  ? 567 VAL B CA  1 
ATOM   5890 C C   . VAL B 1 567 ? 114.766 140.696 142.576 1.00 50.00  ? 567 VAL B C   1 
ATOM   5891 O O   . VAL B 1 567 ? 114.181 141.494 143.333 1.00 50.21  ? 567 VAL B O   1 
ATOM   5892 C CB  . VAL B 1 567 ? 113.702 139.141 140.887 1.00 40.81  ? 567 VAL B CB  1 
ATOM   5893 C CG1 . VAL B 1 567 ? 112.532 138.935 141.827 1.00 41.86  ? 567 VAL B CG1 1 
ATOM   5894 C CG2 . VAL B 1 567 ? 113.257 138.996 139.447 1.00 41.38  ? 567 VAL B CG2 1 
ATOM   5895 N N   . ILE B 1 568 ? 115.821 139.979 142.975 1.00 51.44  ? 568 ILE B N   1 
ATOM   5896 C CA  . ILE B 1 568 ? 116.230 139.985 144.378 1.00 49.31  ? 568 ILE B CA  1 
ATOM   5897 C C   . ILE B 1 568 ? 116.635 141.389 144.811 1.00 46.86  ? 568 ILE B C   1 
ATOM   5898 O O   . ILE B 1 568 ? 116.189 141.895 145.849 1.00 47.52  ? 568 ILE B O   1 
ATOM   5899 C CB  . ILE B 1 568 ? 117.364 138.972 144.607 1.00 48.43  ? 568 ILE B CB  1 
ATOM   5900 C CG1 . ILE B 1 568 ? 116.886 137.558 144.277 1.00 48.32  ? 568 ILE B CG1 1 
ATOM   5901 C CG2 . ILE B 1 568 ? 117.865 139.046 146.039 1.00 50.67  ? 568 ILE B CG2 1 
ATOM   5902 C CD1 . ILE B 1 568 ? 117.952 136.503 144.440 1.00 46.54  ? 568 ILE B CD1 1 
ATOM   5903 N N   . LEU B 1 569 ? 117.462 142.055 144.005 1.00 42.01  ? 569 LEU B N   1 
ATOM   5904 C CA  . LEU B 1 569 ? 117.966 143.366 144.372 1.00 39.82  ? 569 LEU B CA  1 
ATOM   5905 C C   . LEU B 1 569 ? 116.949 144.476 144.163 1.00 42.55  ? 569 LEU B C   1 
ATOM   5906 O O   . LEU B 1 569 ? 117.081 145.523 144.790 1.00 47.93  ? 569 LEU B O   1 
ATOM   5907 C CB  . LEU B 1 569 ? 119.248 143.668 143.597 1.00 42.23  ? 569 LEU B CB  1 
ATOM   5908 C CG  . LEU B 1 569 ? 120.437 142.788 143.986 1.00 34.64  ? 569 LEU B CG  1 
ATOM   5909 C CD1 . LEU B 1 569 ? 121.714 143.283 143.340 1.00 30.67  ? 569 LEU B CD1 1 
ATOM   5910 C CD2 . LEU B 1 569 ? 120.589 142.733 145.493 1.00 36.28  ? 569 LEU B CD2 1 
ATOM   5911 N N   . ARG B 1 570 ? 115.916 144.270 143.345 1.00 44.36  ? 570 ARG B N   1 
ATOM   5912 C CA  . ARG B 1 570 ? 114.824 145.234 143.294 1.00 43.36  ? 570 ARG B CA  1 
ATOM   5913 C C   . ARG B 1 570 ? 114.034 145.213 144.590 1.00 48.22  ? 570 ARG B C   1 
ATOM   5914 O O   . ARG B 1 570 ? 113.720 146.267 145.159 1.00 58.05  ? 570 ARG B O   1 
ATOM   5915 C CB  . ARG B 1 570 ? 113.912 144.941 142.106 1.00 39.87  ? 570 ARG B CB  1 
ATOM   5916 C CG  . ARG B 1 570 ? 114.275 145.698 140.848 1.00 41.90  ? 570 ARG B CG  1 
ATOM   5917 C CD  . ARG B 1 570 ? 114.272 147.189 141.107 1.00 42.92  ? 570 ARG B CD  1 
ATOM   5918 N NE  . ARG B 1 570 ? 114.417 147.957 139.878 1.00 42.88  ? 570 ARG B NE  1 
ATOM   5919 C CZ  . ARG B 1 570 ? 114.491 149.278 139.827 1.00 42.09  ? 570 ARG B CZ  1 
ATOM   5920 N NH1 . ARG B 1 570 ? 114.456 150.014 140.925 1.00 44.95  ? 570 ARG B NH1 1 
ATOM   5921 N NH2 . ARG B 1 570 ? 114.604 149.876 138.646 1.00 42.69  ? 570 ARG B NH2 1 
ATOM   5922 N N   . PHE B 1 571 ? 113.718 144.015 145.087 1.00 50.72  ? 571 PHE B N   1 
ATOM   5923 C CA  . PHE B 1 571 ? 113.036 143.955 146.378 1.00 51.12  ? 571 PHE B CA  1 
ATOM   5924 C C   . PHE B 1 571 ? 113.929 144.484 147.502 1.00 50.38  ? 571 PHE B C   1 
ATOM   5925 O O   . PHE B 1 571 ? 113.454 145.194 148.402 1.00 48.57  ? 571 PHE B O   1 
ATOM   5926 C CB  . PHE B 1 571 ? 112.557 142.532 146.652 1.00 48.28  ? 571 PHE B CB  1 
ATOM   5927 C CG  . PHE B 1 571 ? 111.328 142.158 145.869 1.00 51.35  ? 571 PHE B CG  1 
ATOM   5928 C CD1 . PHE B 1 571 ? 111.435 141.623 144.597 1.00 49.36  ? 571 PHE B CD1 1 
ATOM   5929 C CD2 . PHE B 1 571 ? 110.067 142.366 146.394 1.00 52.65  ? 571 PHE B CD2 1 
ATOM   5930 C CE1 . PHE B 1 571 ? 110.309 141.290 143.872 1.00 45.09  ? 571 PHE B CE1 1 
ATOM   5931 C CE2 . PHE B 1 571 ? 108.937 142.035 145.672 1.00 52.68  ? 571 PHE B CE2 1 
ATOM   5932 C CZ  . PHE B 1 571 ? 109.060 141.497 144.410 1.00 55.23  ? 571 PHE B CZ  1 
ATOM   5933 N N   . ALA B 1 572 ? 115.229 144.175 147.450 1.00 50.54  ? 572 ALA B N   1 
ATOM   5934 C CA  . ALA B 1 572 ? 116.161 144.703 148.445 1.00 46.02  ? 572 ALA B CA  1 
ATOM   5935 C C   . ALA B 1 572 ? 116.259 146.225 148.376 1.00 49.71  ? 572 ALA B C   1 
ATOM   5936 O O   . ALA B 1 572 ? 116.315 146.896 149.412 1.00 60.23  ? 572 ALA B O   1 
ATOM   5937 C CB  . ALA B 1 572 ? 117.537 144.067 148.262 1.00 47.64  ? 572 ALA B CB  1 
ATOM   5938 N N   . TRP B 1 573 ? 116.295 146.787 147.167 1.00 51.45  ? 573 TRP B N   1 
ATOM   5939 C CA  . TRP B 1 573 ? 116.336 148.235 147.013 1.00 53.61  ? 573 TRP B CA  1 
ATOM   5940 C C   . TRP B 1 573 ? 115.084 148.879 147.575 1.00 50.83  ? 573 TRP B C   1 
ATOM   5941 O O   . TRP B 1 573 ? 115.159 149.914 148.242 1.00 55.10  ? 573 TRP B O   1 
ATOM   5942 C CB  . TRP B 1 573 ? 116.503 148.598 145.537 1.00 52.97  ? 573 TRP B CB  1 
ATOM   5943 C CG  . TRP B 1 573 ? 116.198 150.032 145.226 1.00 58.07  ? 573 TRP B CG  1 
ATOM   5944 C CD1 . TRP B 1 573 ? 117.018 151.104 145.417 1.00 57.60  ? 573 TRP B CD1 1 
ATOM   5945 C CD2 . TRP B 1 573 ? 114.989 150.548 144.659 1.00 59.29  ? 573 TRP B CD2 1 
ATOM   5946 N NE1 . TRP B 1 573 ? 116.393 152.256 145.009 1.00 54.64  ? 573 TRP B NE1 1 
ATOM   5947 C CE2 . TRP B 1 573 ? 115.146 151.942 144.540 1.00 56.55  ? 573 TRP B CE2 1 
ATOM   5948 C CE3 . TRP B 1 573 ? 113.787 149.968 144.245 1.00 57.45  ? 573 TRP B CE3 1 
ATOM   5949 C CZ2 . TRP B 1 573 ? 114.148 152.762 144.025 1.00 56.01  ? 573 TRP B CZ2 1 
ATOM   5950 C CZ3 . TRP B 1 573 ? 112.798 150.785 143.733 1.00 59.69  ? 573 TRP B CZ3 1 
ATOM   5951 C CH2 . TRP B 1 573 ? 112.984 152.166 143.628 1.00 59.90  ? 573 TRP B CH2 1 
ATOM   5952 N N   . THR B 1 574 ? 113.920 148.284 147.313 1.00 52.77  ? 574 THR B N   1 
ATOM   5953 C CA  . THR B 1 574 ? 112.680 148.845 147.835 1.00 52.98  ? 574 THR B CA  1 
ATOM   5954 C C   . THR B 1 574 ? 112.676 148.841 149.361 1.00 57.57  ? 574 THR B C   1 
ATOM   5955 O O   . THR B 1 574 ? 112.340 149.849 149.998 1.00 56.55  ? 574 THR B O   1 
ATOM   5956 C CB  . THR B 1 574 ? 111.488 148.065 147.287 1.00 55.64  ? 574 THR B CB  1 
ATOM   5957 O OG1 . THR B 1 574 ? 111.866 147.418 146.067 1.00 67.93  ? 574 THR B OG1 1 
ATOM   5958 C CG2 . THR B 1 574 ? 110.339 149.001 146.998 1.00 55.04  ? 574 THR B CG2 1 
ATOM   5959 N N   . ILE B 1 575 ? 113.079 147.722 149.972 1.00 63.78  ? 575 ILE B N   1 
ATOM   5960 C CA  . ILE B 1 575 ? 113.042 147.665 151.432 1.00 58.91  ? 575 ILE B CA  1 
ATOM   5961 C C   . ILE B 1 575 ? 114.071 148.618 152.036 1.00 57.22  ? 575 ILE B C   1 
ATOM   5962 O O   . ILE B 1 575 ? 113.801 149.273 153.049 1.00 62.96  ? 575 ILE B O   1 
ATOM   5963 C CB  . ILE B 1 575 ? 113.216 146.220 151.941 1.00 52.22  ? 575 ILE B CB  1 
ATOM   5964 C CG1 . ILE B 1 575 ? 113.105 146.175 153.466 1.00 57.26  ? 575 ILE B CG1 1 
ATOM   5965 C CG2 . ILE B 1 575 ? 114.534 145.628 151.513 1.00 49.83  ? 575 ILE B CG2 1 
ATOM   5966 C CD1 . ILE B 1 575 ? 111.782 146.664 154.000 1.00 65.25  ? 575 ILE B CD1 1 
ATOM   5967 N N   . GLN B 1 576 ? 115.250 148.744 151.417 1.00 55.90  ? 576 GLN B N   1 
ATOM   5968 C CA  . GLN B 1 576 ? 116.257 149.636 151.984 1.00 56.75  ? 576 GLN B CA  1 
ATOM   5969 C C   . GLN B 1 576 ? 115.900 151.103 151.771 1.00 62.14  ? 576 GLN B C   1 
ATOM   5970 O O   . GLN B 1 576 ? 116.237 151.945 152.609 1.00 71.00  ? 576 GLN B O   1 
ATOM   5971 C CB  . GLN B 1 576 ? 117.639 149.321 151.406 1.00 57.07  ? 576 GLN B CB  1 
ATOM   5972 C CG  . GLN B 1 576 ? 117.935 149.929 150.045 1.00 63.40  ? 576 GLN B CG  1 
ATOM   5973 C CD  . GLN B 1 576 ? 118.760 151.198 150.137 1.00 64.97  ? 576 GLN B CD  1 
ATOM   5974 O OE1 . GLN B 1 576 ? 118.986 151.728 151.223 1.00 62.47  ? 576 GLN B OE1 1 
ATOM   5975 N NE2 . GLN B 1 576 ? 119.218 151.690 148.992 1.00 66.36  ? 576 GLN B NE2 1 
ATOM   5976 N N   . ILE B 1 577 ? 115.209 151.432 150.677 1.00 63.16  ? 577 ILE B N   1 
ATOM   5977 C CA  . ILE B 1 577 ? 114.793 152.813 150.466 1.00 60.51  ? 577 ILE B CA  1 
ATOM   5978 C C   . ILE B 1 577 ? 113.635 153.159 151.386 1.00 64.41  ? 577 ILE B C   1 
ATOM   5979 O O   . ILE B 1 577 ? 113.432 154.330 151.727 1.00 70.98  ? 577 ILE B O   1 
ATOM   5980 C CB  . ILE B 1 577 ? 114.446 153.055 148.984 1.00 57.49  ? 577 ILE B CB  1 
ATOM   5981 C CG1 . ILE B 1 577 ? 114.566 154.535 148.642 1.00 65.44  ? 577 ILE B CG1 1 
ATOM   5982 C CG2 . ILE B 1 577 ? 113.039 152.599 148.663 1.00 63.60  ? 577 ILE B CG2 1 
ATOM   5983 C CD1 . ILE B 1 577 ? 114.161 154.862 147.228 1.00 68.83  ? 577 ILE B CD1 1 
ATOM   5984 N N   . SER B 1 578 ? 112.854 152.160 151.804 1.00 68.17  ? 578 SER B N   1 
ATOM   5985 C CA  . SER B 1 578 ? 111.843 152.414 152.826 1.00 67.71  ? 578 SER B CA  1 
ATOM   5986 C C   . SER B 1 578 ? 112.480 152.592 154.199 1.00 69.65  ? 578 SER B C   1 
ATOM   5987 O O   . SER B 1 578 ? 112.066 153.462 154.973 1.00 73.19  ? 578 SER B O   1 
ATOM   5988 C CB  . SER B 1 578 ? 110.827 151.277 152.854 1.00 71.29  ? 578 SER B CB  1 
ATOM   5989 O OG  . SER B 1 578 ? 110.331 151.016 151.558 1.00 72.34  ? 578 SER B OG  1 
ATOM   5990 N N   . ILE B 1 579 ? 113.482 151.772 154.520 1.00 73.29  ? 579 ILE B N   1 
ATOM   5991 C CA  . ILE B 1 579 ? 114.083 151.812 155.850 1.00 72.18  ? 579 ILE B CA  1 
ATOM   5992 C C   . ILE B 1 579 ? 114.904 153.083 156.040 1.00 72.73  ? 579 ILE B C   1 
ATOM   5993 O O   . ILE B 1 579 ? 114.823 153.740 157.084 1.00 82.02  ? 579 ILE B O   1 
ATOM   5994 C CB  . ILE B 1 579 ? 114.928 150.549 156.091 1.00 71.25  ? 579 ILE B CB  1 
ATOM   5995 C CG1 . ILE B 1 579 ? 114.018 149.327 156.227 1.00 74.61  ? 579 ILE B CG1 1 
ATOM   5996 C CG2 . ILE B 1 579 ? 115.791 150.709 157.330 1.00 74.12  ? 579 ILE B CG2 1 
ATOM   5997 C CD1 . ILE B 1 579 ? 114.760 148.025 156.392 1.00 73.52  ? 579 ILE B CD1 1 
ATOM   5998 N N   . THR B 1 580 ? 115.707 153.449 155.038 1.00 72.31  ? 580 THR B N   1 
ATOM   5999 C CA  . THR B 1 580 ? 116.601 154.595 155.186 1.00 75.46  ? 580 THR B CA  1 
ATOM   6000 C C   . THR B 1 580 ? 115.825 155.890 155.387 1.00 76.10  ? 580 THR B C   1 
ATOM   6001 O O   . THR B 1 580 ? 116.200 156.724 156.219 1.00 78.64  ? 580 THR B O   1 
ATOM   6002 C CB  . THR B 1 580 ? 117.519 154.706 153.968 1.00 75.15  ? 580 THR B CB  1 
ATOM   6003 O OG1 . THR B 1 580 ? 118.364 153.551 153.900 1.00 82.23  ? 580 THR B OG1 1 
ATOM   6004 C CG2 . THR B 1 580 ? 118.388 155.949 154.062 1.00 72.31  ? 580 THR B CG2 1 
ATOM   6005 N N   . SER B 1 581 ? 114.734 156.073 154.644 1.00 78.90  ? 581 SER B N   1 
ATOM   6006 C CA  . SER B 1 581 ? 113.967 157.311 154.718 1.00 84.04  ? 581 SER B CA  1 
ATOM   6007 C C   . SER B 1 581 ? 113.219 157.476 156.035 1.00 85.68  ? 581 SER B C   1 
ATOM   6008 O O   . SER B 1 581 ? 112.719 158.572 156.306 1.00 85.75  ? 581 SER B O   1 
ATOM   6009 C CB  . SER B 1 581 ? 112.977 157.380 153.555 1.00 79.11  ? 581 SER B CB  1 
ATOM   6010 O OG  . SER B 1 581 ? 112.079 156.285 153.585 1.00 76.78  ? 581 SER B OG  1 
ATOM   6011 N N   . THR B 1 582 ? 113.128 156.429 156.854 1.00 84.92  ? 582 THR B N   1 
ATOM   6012 C CA  . THR B 1 582 ? 112.364 156.504 158.093 1.00 91.29  ? 582 THR B CA  1 
ATOM   6013 C C   . THR B 1 582 ? 113.150 155.938 159.269 1.00 98.73  ? 582 THR B C   1 
ATOM   6014 O O   . THR B 1 582 ? 114.343 155.646 159.146 1.00 98.56  ? 582 THR B O   1 
ATOM   6015 C CB  . THR B 1 582 ? 111.036 155.759 157.949 1.00 89.95  ? 582 THR B CB  1 
ATOM   6016 O OG1 . THR B 1 582 ? 111.281 154.428 157.476 1.00 92.85  ? 582 THR B OG1 1 
ATOM   6017 C CG2 . THR B 1 582 ? 110.117 156.477 156.976 1.00 84.06  ? 582 THR B CG2 1 
ATOM   6018 N N   . THR B 1 583 ? 112.491 155.792 160.415 1.00 103.24 ? 583 THR B N   1 
ATOM   6019 C CA  . THR B 1 583 ? 113.080 155.208 161.613 1.00 107.34 ? 583 THR B CA  1 
ATOM   6020 C C   . THR B 1 583 ? 112.233 154.045 162.115 1.00 108.28 ? 583 THR B C   1 
ATOM   6021 O O   . THR B 1 583 ? 112.051 153.857 163.319 1.00 113.24 ? 583 THR B O   1 
ATOM   6022 C CB  . THR B 1 583 ? 113.250 156.254 162.713 1.00 105.24 ? 583 THR B CB  1 
ATOM   6023 O OG1 . THR B 1 583 ? 111.964 156.753 163.103 1.00 104.03 ? 583 THR B OG1 1 
ATOM   6024 C CG2 . THR B 1 583 ? 114.110 157.412 162.225 1.00 104.91 ? 583 THR B CG2 1 
ATOM   6025 N N   . LEU B 1 584 ? 111.703 153.248 161.186 1.00 106.82 ? 584 LEU B N   1 
ATOM   6026 C CA  . LEU B 1 584 ? 110.795 152.166 161.547 1.00 113.30 ? 584 LEU B CA  1 
ATOM   6027 C C   . LEU B 1 584 ? 111.507 150.963 162.153 1.00 120.68 ? 584 LEU B C   1 
ATOM   6028 O O   . LEU B 1 584 ? 110.832 150.073 162.682 1.00 121.36 ? 584 LEU B O   1 
ATOM   6029 C CB  . LEU B 1 584 ? 109.982 151.729 160.324 1.00 110.18 ? 584 LEU B CB  1 
ATOM   6030 C CG  . LEU B 1 584 ? 110.585 150.744 159.318 1.00 111.38 ? 584 LEU B CG  1 
ATOM   6031 C CD1 . LEU B 1 584 ? 109.557 150.397 158.252 1.00 107.50 ? 584 LEU B CD1 1 
ATOM   6032 C CD2 . LEU B 1 584 ? 111.847 151.289 158.674 1.00 97.08  ? 584 LEU B CD2 1 
ATOM   6033 N N   . LEU B 1 585 ? 112.834 150.906 162.089 1.00 120.53 ? 585 LEU B N   1 
ATOM   6034 C CA  . LEU B 1 585 ? 113.606 149.829 162.711 1.00 122.86 ? 585 LEU B CA  1 
ATOM   6035 C C   . LEU B 1 585 ? 114.580 150.415 163.722 1.00 128.97 ? 585 LEU B C   1 
ATOM   6036 O O   . LEU B 1 585 ? 115.676 150.863 163.342 1.00 127.96 ? 585 LEU B O   1 
ATOM   6037 C CB  . LEU B 1 585 ? 114.355 149.011 161.661 1.00 118.93 ? 585 LEU B CB  1 
ATOM   6038 C CG  . LEU B 1 585 ? 113.514 148.055 160.815 1.00 120.88 ? 585 LEU B CG  1 
ATOM   6039 C CD1 . LEU B 1 585 ? 114.410 147.191 159.947 1.00 114.00 ? 585 LEU B CD1 1 
ATOM   6040 C CD2 . LEU B 1 585 ? 112.631 147.192 161.699 1.00 123.09 ? 585 LEU B CD2 1 
ATOM   6041 N N   . PRO B 1 586 ? 114.226 150.451 165.011 1.00 134.04 ? 586 PRO B N   1 
ATOM   6042 C CA  . PRO B 1 586 ? 115.185 150.948 166.013 1.00 135.33 ? 586 PRO B CA  1 
ATOM   6043 C C   . PRO B 1 586 ? 116.477 150.152 166.049 1.00 134.33 ? 586 PRO B C   1 
ATOM   6044 O O   . PRO B 1 586 ? 117.554 150.730 166.242 1.00 131.57 ? 586 PRO B O   1 
ATOM   6045 C CB  . PRO B 1 586 ? 114.403 150.831 167.329 1.00 134.87 ? 586 PRO B CB  1 
ATOM   6046 C CG  . PRO B 1 586 ? 112.964 150.831 166.921 1.00 132.60 ? 586 PRO B CG  1 
ATOM   6047 C CD  . PRO B 1 586 ? 112.922 150.116 165.606 1.00 131.10 ? 586 PRO B CD  1 
ATOM   6048 N N   . HIS B 1 587 ? 116.399 148.839 165.865 1.00 133.40 ? 587 HIS B N   1 
ATOM   6049 C CA  . HIS B 1 587 ? 117.573 147.984 165.786 1.00 131.00 ? 587 HIS B CA  1 
ATOM   6050 C C   . HIS B 1 587 ? 117.875 147.661 164.329 1.00 125.80 ? 587 HIS B C   1 
ATOM   6051 O O   . HIS B 1 587 ? 116.980 147.650 163.480 1.00 122.50 ? 587 HIS B O   1 
ATOM   6052 C CB  . HIS B 1 587 ? 117.369 146.691 166.578 1.00 136.10 ? 587 HIS B CB  1 
ATOM   6053 C CG  . HIS B 1 587 ? 117.321 146.891 168.061 1.00 146.65 ? 587 HIS B CG  1 
ATOM   6054 N ND1 . HIS B 1 587 ? 118.435 146.772 168.864 1.00 150.34 ? 587 HIS B ND1 1 
ATOM   6055 C CD2 . HIS B 1 587 ? 116.293 147.199 168.887 1.00 150.32 ? 587 HIS B CD2 1 
ATOM   6056 C CE1 . HIS B 1 587 ? 118.096 147.000 170.121 1.00 152.29 ? 587 HIS B CE1 1 
ATOM   6057 N NE2 . HIS B 1 587 ? 116.802 147.261 170.162 1.00 154.02 ? 587 HIS B NE2 1 
ATOM   6058 N N   . SER B 1 588 ? 119.146 147.395 164.052 1.00 121.86 ? 588 SER B N   1 
ATOM   6059 C CA  . SER B 1 588 ? 119.640 147.151 162.686 1.00 110.15 ? 588 SER B CA  1 
ATOM   6060 C C   . SER B 1 588 ? 119.266 148.378 161.850 1.00 110.09 ? 588 SER B C   1 
ATOM   6061 O O   . SER B 1 588 ? 119.414 149.515 162.324 1.00 111.28 ? 588 SER B O   1 
ATOM   6062 C CB  . SER B 1 588 ? 119.116 145.828 162.161 1.00 110.99 ? 588 SER B CB  1 
ATOM   6063 O OG  . SER B 1 588 ? 117.718 145.877 161.938 1.00 115.14 ? 588 SER B OG  1 
ATOM   6064 N N   . GLY B 1 589 ? 118.782 148.197 160.625 1.00 105.16 ? 589 GLY B N   1 
ATOM   6065 C CA  . GLY B 1 589 ? 118.430 149.325 159.786 1.00 100.01 ? 589 GLY B CA  1 
ATOM   6066 C C   . GLY B 1 589 ? 119.644 149.969 159.155 1.00 88.66  ? 589 GLY B C   1 
ATOM   6067 O O   . GLY B 1 589 ? 119.768 150.003 157.928 1.00 87.92  ? 589 GLY B O   1 
ATOM   6068 N N   . ASP B 1 590 ? 120.546 150.493 159.987 1.00 87.91  ? 590 ASP B N   1 
ATOM   6069 C CA  . ASP B 1 590 ? 121.806 151.013 159.469 1.00 84.33  ? 590 ASP B CA  1 
ATOM   6070 C C   . ASP B 1 590 ? 122.647 149.902 158.857 1.00 81.17  ? 590 ASP B C   1 
ATOM   6071 O O   . ASP B 1 590 ? 123.274 150.098 157.810 1.00 81.25  ? 590 ASP B O   1 
ATOM   6072 C CB  . ASP B 1 590 ? 122.576 151.726 160.579 1.00 90.37  ? 590 ASP B CB  1 
ATOM   6073 C CG  . ASP B 1 590 ? 121.989 153.081 160.914 1.00 94.76  ? 590 ASP B CG  1 
ATOM   6074 O OD1 . ASP B 1 590 ? 121.579 153.798 159.977 1.00 85.42  ? 590 ASP B OD1 1 
ATOM   6075 O OD2 . ASP B 1 590 ? 121.935 153.429 162.112 1.00 103.28 ? 590 ASP B OD2 1 
ATOM   6076 N N   . ILE B 1 591 ? 122.669 148.729 159.492 1.00 81.41  ? 591 ILE B N   1 
ATOM   6077 C CA  . ILE B 1 591 ? 123.379 147.588 158.921 1.00 77.08  ? 591 ILE B CA  1 
ATOM   6078 C C   . ILE B 1 591 ? 122.754 147.186 157.593 1.00 73.35  ? 591 ILE B C   1 
ATOM   6079 O O   . ILE B 1 591 ? 123.458 146.931 156.608 1.00 69.42  ? 591 ILE B O   1 
ATOM   6080 C CB  . ILE B 1 591 ? 123.389 146.410 159.913 1.00 77.88  ? 591 ILE B CB  1 
ATOM   6081 C CG1 . ILE B 1 591 ? 123.920 146.856 161.274 1.00 84.95  ? 591 ILE B CG1 1 
ATOM   6082 C CG2 . ILE B 1 591 ? 124.219 145.263 159.367 1.00 66.61  ? 591 ILE B CG2 1 
ATOM   6083 C CD1 . ILE B 1 591 ? 123.979 145.747 162.298 1.00 87.89  ? 591 ILE B CD1 1 
ATOM   6084 N N   . ILE B 1 592 ? 121.422 147.128 157.544 1.00 74.04  ? 592 ILE B N   1 
ATOM   6085 C CA  . ILE B 1 592 ? 120.747 146.667 156.338 1.00 72.71  ? 592 ILE B CA  1 
ATOM   6086 C C   . ILE B 1 592 ? 120.928 147.673 155.206 1.00 68.99  ? 592 ILE B C   1 
ATOM   6087 O O   . ILE B 1 592 ? 121.144 147.291 154.051 1.00 68.08  ? 592 ILE B O   1 
ATOM   6088 C CB  . ILE B 1 592 ? 119.264 146.364 156.641 1.00 73.97  ? 592 ILE B CB  1 
ATOM   6089 C CG1 . ILE B 1 592 ? 118.790 145.154 155.838 1.00 69.01  ? 592 ILE B CG1 1 
ATOM   6090 C CG2 . ILE B 1 592 ? 118.362 147.556 156.363 1.00 71.99  ? 592 ILE B CG2 1 
ATOM   6091 C CD1 . ILE B 1 592 ? 117.356 144.769 156.114 1.00 70.33  ? 592 ILE B CD1 1 
ATOM   6092 N N   . ALA B 1 593 ? 120.895 148.971 155.519 1.00 67.72  ? 593 ALA B N   1 
ATOM   6093 C CA  . ALA B 1 593 ? 121.133 149.978 154.491 1.00 65.90  ? 593 ALA B CA  1 
ATOM   6094 C C   . ALA B 1 593 ? 122.580 149.949 154.018 1.00 68.76  ? 593 ALA B C   1 
ATOM   6095 O O   . ALA B 1 593 ? 122.850 150.076 152.818 1.00 71.27  ? 593 ALA B O   1 
ATOM   6096 C CB  . ALA B 1 593 ? 120.766 151.364 155.017 1.00 63.49  ? 593 ALA B CB  1 
ATOM   6097 N N   . THR B 1 594 ? 123.521 149.770 154.948 1.00 66.68  ? 594 THR B N   1 
ATOM   6098 C CA  . THR B 1 594 ? 124.933 149.731 154.589 1.00 59.65  ? 594 THR B CA  1 
ATOM   6099 C C   . THR B 1 594 ? 125.251 148.526 153.714 1.00 59.21  ? 594 THR B C   1 
ATOM   6100 O O   . THR B 1 594 ? 126.109 148.607 152.828 1.00 59.90  ? 594 THR B O   1 
ATOM   6101 C CB  . THR B 1 594 ? 125.793 149.719 155.853 1.00 63.77  ? 594 THR B CB  1 
ATOM   6102 O OG1 . THR B 1 594 ? 125.449 150.841 156.675 1.00 69.42  ? 594 THR B OG1 1 
ATOM   6103 C CG2 . THR B 1 594 ? 127.266 149.800 155.500 1.00 65.14  ? 594 THR B CG2 1 
ATOM   6104 N N   . VAL B 1 595 ? 124.579 147.397 153.944 1.00 59.82  ? 595 VAL B N   1 
ATOM   6105 C CA  . VAL B 1 595 ? 124.821 146.225 153.109 1.00 60.87  ? 595 VAL B CA  1 
ATOM   6106 C C   . VAL B 1 595 ? 123.990 146.219 151.830 1.00 57.31  ? 595 VAL B C   1 
ATOM   6107 O O   . VAL B 1 595 ? 124.341 145.501 150.884 1.00 56.83  ? 595 VAL B O   1 
ATOM   6108 C CB  . VAL B 1 595 ? 124.572 144.917 153.883 1.00 60.77  ? 595 VAL B CB  1 
ATOM   6109 C CG1 . VAL B 1 595 ? 125.436 144.865 155.131 1.00 67.29  ? 595 VAL B CG1 1 
ATOM   6110 C CG2 . VAL B 1 595 ? 123.107 144.768 154.233 1.00 62.52  ? 595 VAL B CG2 1 
ATOM   6111 N N   . PHE B 1 596 ? 122.909 146.996 151.765 1.00 57.41  ? 596 PHE B N   1 
ATOM   6112 C CA  . PHE B 1 596 ? 122.064 147.007 150.579 1.00 53.93  ? 596 PHE B CA  1 
ATOM   6113 C C   . PHE B 1 596 ? 122.407 148.107 149.587 1.00 53.85  ? 596 PHE B C   1 
ATOM   6114 O O   . PHE B 1 596 ? 122.104 147.959 148.399 1.00 55.97  ? 596 PHE B O   1 
ATOM   6115 C CB  . PHE B 1 596 ? 120.591 147.142 150.977 1.00 58.18  ? 596 PHE B CB  1 
ATOM   6116 C CG  . PHE B 1 596 ? 119.984 145.871 151.498 1.00 63.84  ? 596 PHE B CG  1 
ATOM   6117 C CD1 . PHE B 1 596 ? 120.691 144.682 151.462 1.00 63.42  ? 596 PHE B CD1 1 
ATOM   6118 C CD2 . PHE B 1 596 ? 118.700 145.864 152.012 1.00 61.75  ? 596 PHE B CD2 1 
ATOM   6119 C CE1 . PHE B 1 596 ? 120.132 143.513 151.937 1.00 60.07  ? 596 PHE B CE1 1 
ATOM   6120 C CE2 . PHE B 1 596 ? 118.137 144.697 152.485 1.00 62.80  ? 596 PHE B CE2 1 
ATOM   6121 C CZ  . PHE B 1 596 ? 118.854 143.522 152.449 1.00 62.56  ? 596 PHE B CZ  1 
ATOM   6122 N N   . ALA B 1 597 ? 123.010 149.211 150.032 1.00 50.75  ? 597 ALA B N   1 
ATOM   6123 C CA  . ALA B 1 597 ? 123.362 150.279 149.097 1.00 44.72  ? 597 ALA B CA  1 
ATOM   6124 C C   . ALA B 1 597 ? 124.388 149.845 148.053 1.00 43.16  ? 597 ALA B C   1 
ATOM   6125 O O   . ALA B 1 597 ? 124.160 150.098 146.856 1.00 38.69  ? 597 ALA B O   1 
ATOM   6126 C CB  . ALA B 1 597 ? 123.826 151.510 149.880 1.00 48.05  ? 597 ALA B CB  1 
ATOM   6127 N N   . PRO B 1 598 ? 125.516 149.212 148.408 1.00 45.04  ? 598 PRO B N   1 
ATOM   6128 C CA  . PRO B 1 598 ? 126.392 148.677 147.355 1.00 33.74  ? 598 PRO B CA  1 
ATOM   6129 C C   . PRO B 1 598 ? 125.708 147.638 146.494 1.00 34.40  ? 598 PRO B C   1 
ATOM   6130 O O   . PRO B 1 598 ? 126.040 147.506 145.311 1.00 37.46  ? 598 PRO B O   1 
ATOM   6131 C CB  . PRO B 1 598 ? 127.568 148.081 148.141 1.00 30.51  ? 598 PRO B CB  1 
ATOM   6132 C CG  . PRO B 1 598 ? 127.044 147.855 149.501 1.00 37.63  ? 598 PRO B CG  1 
ATOM   6133 C CD  . PRO B 1 598 ? 126.087 148.969 149.744 1.00 44.90  ? 598 PRO B CD  1 
ATOM   6134 N N   . LEU B 1 599 ? 124.745 146.902 147.049 1.00 36.33  ? 599 LEU B N   1 
ATOM   6135 C CA  . LEU B 1 599 ? 123.979 145.962 146.243 1.00 34.79  ? 599 LEU B CA  1 
ATOM   6136 C C   . LEU B 1 599 ? 123.110 146.687 145.223 1.00 35.50  ? 599 LEU B C   1 
ATOM   6137 O O   . LEU B 1 599 ? 122.944 146.210 144.098 1.00 36.42  ? 599 LEU B O   1 
ATOM   6138 C CB  . LEU B 1 599 ? 123.132 145.066 147.143 1.00 35.61  ? 599 LEU B CB  1 
ATOM   6139 C CG  . LEU B 1 599 ? 123.931 144.045 147.950 1.00 40.07  ? 599 LEU B CG  1 
ATOM   6140 C CD1 . LEU B 1 599 ? 123.011 143.217 148.824 1.00 52.02  ? 599 LEU B CD1 1 
ATOM   6141 C CD2 . LEU B 1 599 ? 124.735 143.156 147.021 1.00 33.89  ? 599 LEU B CD2 1 
ATOM   6142 N N   . GLU B 1 600 ? 122.554 147.845 145.587 1.00 33.51  ? 600 GLU B N   1 
ATOM   6143 C CA  . GLU B 1 600 ? 121.791 148.620 144.612 1.00 31.92  ? 600 GLU B CA  1 
ATOM   6144 C C   . GLU B 1 600 ? 122.702 149.223 143.551 1.00 30.38  ? 600 GLU B C   1 
ATOM   6145 O O   . GLU B 1 600 ? 122.326 149.308 142.376 1.00 33.28  ? 600 GLU B O   1 
ATOM   6146 C CB  . GLU B 1 600 ? 120.979 149.709 145.312 1.00 38.15  ? 600 GLU B CB  1 
ATOM   6147 C CG  . GLU B 1 600 ? 120.367 150.743 144.373 1.00 46.21  ? 600 GLU B CG  1 
ATOM   6148 C CD  . GLU B 1 600 ? 119.455 150.139 143.313 1.00 55.76  ? 600 GLU B CD  1 
ATOM   6149 O OE1 . GLU B 1 600 ? 118.879 149.058 143.551 1.00 56.71  ? 600 GLU B OE1 1 
ATOM   6150 O OE2 . GLU B 1 600 ? 119.311 150.752 142.236 1.00 52.58  ? 600 GLU B OE2 1 
ATOM   6151 N N   . VAL B 1 601 ? 123.907 149.643 143.941 1.00 28.33  ? 601 VAL B N   1 
ATOM   6152 C CA  . VAL B 1 601 ? 124.871 150.103 142.944 1.00 26.31  ? 601 VAL B CA  1 
ATOM   6153 C C   . VAL B 1 601 ? 125.214 148.974 141.979 1.00 29.41  ? 601 VAL B C   1 
ATOM   6154 O O   . VAL B 1 601 ? 125.307 149.183 140.765 1.00 31.54  ? 601 VAL B O   1 
ATOM   6155 C CB  . VAL B 1 601 ? 126.128 150.671 143.627 1.00 27.27  ? 601 VAL B CB  1 
ATOM   6156 C CG1 . VAL B 1 601 ? 127.178 151.020 142.591 1.00 26.27  ? 601 VAL B CG1 1 
ATOM   6157 C CG2 . VAL B 1 601 ? 125.775 151.893 144.450 1.00 27.73  ? 601 VAL B CG2 1 
ATOM   6158 N N   . PHE B 1 602 ? 125.396 147.759 142.500 1.00 28.06  ? 602 PHE B N   1 
ATOM   6159 C CA  . PHE B 1 602 ? 125.674 146.609 141.644 1.00 23.68  ? 602 PHE B CA  1 
ATOM   6160 C C   . PHE B 1 602 ? 124.485 146.278 140.747 1.00 29.19  ? 602 PHE B C   1 
ATOM   6161 O O   . PHE B 1 602 ? 124.663 145.877 139.590 1.00 30.89  ? 602 PHE B O   1 
ATOM   6162 C CB  . PHE B 1 602 ? 126.054 145.405 142.505 1.00 26.30  ? 602 PHE B CB  1 
ATOM   6163 C CG  . PHE B 1 602 ? 126.401 144.179 141.714 1.00 30.21  ? 602 PHE B CG  1 
ATOM   6164 C CD1 . PHE B 1 602 ? 127.645 144.050 141.126 1.00 26.61  ? 602 PHE B CD1 1 
ATOM   6165 C CD2 . PHE B 1 602 ? 125.485 143.153 141.566 1.00 28.34  ? 602 PHE B CD2 1 
ATOM   6166 C CE1 . PHE B 1 602 ? 127.966 142.927 140.400 1.00 28.38  ? 602 PHE B CE1 1 
ATOM   6167 C CE2 . PHE B 1 602 ? 125.800 142.028 140.841 1.00 25.93  ? 602 PHE B CE2 1 
ATOM   6168 C CZ  . PHE B 1 602 ? 127.042 141.914 140.258 1.00 28.46  ? 602 PHE B CZ  1 
ATOM   6169 N N   . ARG B 1 603 ? 123.265 146.421 141.267 1.00 30.83  ? 603 ARG B N   1 
ATOM   6170 C CA  . ARG B 1 603 ? 122.081 146.187 140.449 1.00 26.80  ? 603 ARG B CA  1 
ATOM   6171 C C   . ARG B 1 603 ? 122.004 147.183 139.303 1.00 29.89  ? 603 ARG B C   1 
ATOM   6172 O O   . ARG B 1 603 ? 121.680 146.811 138.172 1.00 32.17  ? 603 ARG B O   1 
ATOM   6173 C CB  . ARG B 1 603 ? 120.817 146.263 141.301 1.00 27.98  ? 603 ARG B CB  1 
ATOM   6174 C CG  . ARG B 1 603 ? 119.584 145.743 140.584 1.00 33.87  ? 603 ARG B CG  1 
ATOM   6175 C CD  . ARG B 1 603 ? 118.301 146.268 141.196 1.00 36.01  ? 603 ARG B CD  1 
ATOM   6176 N NE  . ARG B 1 603 ? 118.200 147.718 141.102 1.00 42.03  ? 603 ARG B NE  1 
ATOM   6177 C CZ  . ARG B 1 603 ? 117.899 148.377 139.992 1.00 44.91  ? 603 ARG B CZ  1 
ATOM   6178 N NH1 . ARG B 1 603 ? 117.690 147.747 138.849 1.00 43.99  ? 603 ARG B NH1 1 
ATOM   6179 N NH2 . ARG B 1 603 ? 117.814 149.703 140.028 1.00 42.45  ? 603 ARG B NH2 1 
ATOM   6180 N N   . ARG B 1 604 ? 122.297 148.456 139.575 1.00 25.86  ? 604 ARG B N   1 
ATOM   6181 C CA  . ARG B 1 604 ? 122.344 149.444 138.501 1.00 22.50  ? 604 ARG B CA  1 
ATOM   6182 C C   . ARG B 1 604 ? 123.478 149.159 137.523 1.00 23.45  ? 604 ARG B C   1 
ATOM   6183 O O   . ARG B 1 604 ? 123.339 149.407 136.320 1.00 28.39  ? 604 ARG B O   1 
ATOM   6184 C CB  . ARG B 1 604 ? 122.485 150.846 139.085 1.00 26.32  ? 604 ARG B CB  1 
ATOM   6185 C CG  . ARG B 1 604 ? 122.455 151.954 138.049 1.00 26.39  ? 604 ARG B CG  1 
ATOM   6186 C CD  . ARG B 1 604 ? 121.149 151.965 137.276 1.00 24.75  ? 604 ARG B CD  1 
ATOM   6187 N NE  . ARG B 1 604 ? 120.019 152.320 138.123 1.00 27.97  ? 604 ARG B NE  1 
ATOM   6188 C CZ  . ARG B 1 604 ? 118.771 152.445 137.694 1.00 31.57  ? 604 ARG B CZ  1 
ATOM   6189 N NH1 . ARG B 1 604 ? 118.455 152.252 136.427 1.00 33.91  ? 604 ARG B NH1 1 
ATOM   6190 N NH2 . ARG B 1 604 ? 117.817 152.774 138.559 1.00 36.78  ? 604 ARG B NH2 1 
ATOM   6191 N N   . PHE B 1 605 ? 124.604 148.646 138.020 1.00 21.87  ? 605 PHE B N   1 
ATOM   6192 C CA  . PHE B 1 605 ? 125.703 148.251 137.145 1.00 16.56  ? 605 PHE B CA  1 
ATOM   6193 C C   . PHE B 1 605 ? 125.271 147.159 136.174 1.00 20.16  ? 605 PHE B C   1 
ATOM   6194 O O   . PHE B 1 605 ? 125.584 147.219 134.981 1.00 21.94  ? 605 PHE B O   1 
ATOM   6195 C CB  . PHE B 1 605 ? 126.886 147.796 138.000 1.00 15.18  ? 605 PHE B CB  1 
ATOM   6196 C CG  . PHE B 1 605 ? 127.784 146.793 137.336 1.00 17.87  ? 605 PHE B CG  1 
ATOM   6197 C CD1 . PHE B 1 605 ? 128.702 147.187 136.388 1.00 16.74  ? 605 PHE B CD1 1 
ATOM   6198 C CD2 . PHE B 1 605 ? 127.737 145.460 137.696 1.00 18.78  ? 605 PHE B CD2 1 
ATOM   6199 C CE1 . PHE B 1 605 ? 129.535 146.272 135.794 1.00 15.89  ? 605 PHE B CE1 1 
ATOM   6200 C CE2 . PHE B 1 605 ? 128.568 144.541 137.100 1.00 15.60  ? 605 PHE B CE2 1 
ATOM   6201 C CZ  . PHE B 1 605 ? 129.469 144.949 136.150 1.00 13.55  ? 605 PHE B CZ  1 
ATOM   6202 N N   . VAL B 1 606 ? 124.549 146.155 136.669 1.00 21.52  ? 606 VAL B N   1 
ATOM   6203 C CA  . VAL B 1 606 ? 124.039 145.106 135.790 1.00 21.06  ? 606 VAL B CA  1 
ATOM   6204 C C   . VAL B 1 606 ? 122.961 145.661 134.863 1.00 25.91  ? 606 VAL B C   1 
ATOM   6205 O O   . VAL B 1 606 ? 122.861 145.266 133.696 1.00 29.68  ? 606 VAL B O   1 
ATOM   6206 C CB  . VAL B 1 606 ? 123.523 143.919 136.621 1.00 22.78  ? 606 VAL B CB  1 
ATOM   6207 C CG1 . VAL B 1 606 ? 122.997 142.824 135.713 1.00 28.41  ? 606 VAL B CG1 1 
ATOM   6208 C CG2 . VAL B 1 606 ? 124.626 143.380 137.505 1.00 22.81  ? 606 VAL B CG2 1 
ATOM   6209 N N   . TRP B 1 607 ? 122.142 146.585 135.367 1.00 29.00  ? 607 TRP B N   1 
ATOM   6210 C CA  . TRP B 1 607 ? 121.073 147.184 134.576 1.00 23.98  ? 607 TRP B CA  1 
ATOM   6211 C C   . TRP B 1 607 ? 121.615 147.971 133.392 1.00 24.06  ? 607 TRP B C   1 
ATOM   6212 O O   . TRP B 1 607 ? 120.987 147.993 132.329 1.00 31.27  ? 607 TRP B O   1 
ATOM   6213 C CB  . TRP B 1 607 ? 120.228 148.084 135.482 1.00 30.06  ? 607 TRP B CB  1 
ATOM   6214 C CG  . TRP B 1 607 ? 119.124 148.849 134.813 1.00 32.86  ? 607 TRP B CG  1 
ATOM   6215 C CD1 . TRP B 1 607 ? 117.819 148.475 134.704 1.00 30.92  ? 607 TRP B CD1 1 
ATOM   6216 C CD2 . TRP B 1 607 ? 119.224 150.137 134.194 1.00 29.98  ? 607 TRP B CD2 1 
ATOM   6217 N NE1 . TRP B 1 607 ? 117.104 149.440 134.042 1.00 29.11  ? 607 TRP B NE1 1 
ATOM   6218 C CE2 . TRP B 1 607 ? 117.944 150.472 133.720 1.00 31.04  ? 607 TRP B CE2 1 
ATOM   6219 C CE3 . TRP B 1 607 ? 120.275 151.035 133.987 1.00 26.69  ? 607 TRP B CE3 1 
ATOM   6220 C CZ2 . TRP B 1 607 ? 117.687 151.665 133.052 1.00 32.62  ? 607 TRP B CZ2 1 
ATOM   6221 C CZ3 . TRP B 1 607 ? 120.017 152.216 133.326 1.00 26.74  ? 607 TRP B CZ3 1 
ATOM   6222 C CH2 . TRP B 1 607 ? 118.735 152.522 132.868 1.00 32.32  ? 607 TRP B CH2 1 
ATOM   6223 N N   . ASN B 1 608 ? 122.759 148.639 133.568 1.00 24.23  ? 608 ASN B N   1 
ATOM   6224 C CA  . ASN B 1 608 ? 123.328 149.451 132.495 1.00 25.04  ? 608 ASN B CA  1 
ATOM   6225 C C   . ASN B 1 608 ? 123.646 148.607 131.269 1.00 30.00  ? 608 ASN B C   1 
ATOM   6226 O O   . ASN B 1 608 ? 123.374 149.022 130.134 1.00 35.67  ? 608 ASN B O   1 
ATOM   6227 C CB  . ASN B 1 608 ? 124.589 150.162 132.981 1.00 22.57  ? 608 ASN B CB  1 
ATOM   6228 C CG  . ASN B 1 608 ? 124.292 151.307 133.921 1.00 28.88  ? 608 ASN B CG  1 
ATOM   6229 O OD1 . ASN B 1 608 ? 123.336 152.051 133.725 1.00 40.31  ? 608 ASN B OD1 1 
ATOM   6230 N ND2 . ASN B 1 608 ? 125.117 151.459 134.947 1.00 27.27  ? 608 ASN B ND2 1 
ATOM   6231 N N   . PHE B 1 609 ? 124.226 147.422 131.481 1.00 25.00  ? 609 PHE B N   1 
ATOM   6232 C CA  . PHE B 1 609 ? 124.552 146.510 130.390 1.00 22.22  ? 609 PHE B CA  1 
ATOM   6233 C C   . PHE B 1 609 ? 123.367 146.324 129.453 1.00 30.12  ? 609 PHE B C   1 
ATOM   6234 O O   . PHE B 1 609 ? 123.422 146.669 128.268 1.00 33.64  ? 609 PHE B O   1 
ATOM   6235 C CB  . PHE B 1 609 ? 124.979 145.154 130.956 1.00 18.96  ? 609 PHE B CB  1 
ATOM   6236 C CG  . PHE B 1 609 ? 126.400 145.102 131.429 1.00 21.83  ? 609 PHE B CG  1 
ATOM   6237 C CD1 . PHE B 1 609 ? 127.429 145.577 130.640 1.00 22.99  ? 609 PHE B CD1 1 
ATOM   6238 C CD2 . PHE B 1 609 ? 126.707 144.560 132.663 1.00 18.99  ? 609 PHE B CD2 1 
ATOM   6239 C CE1 . PHE B 1 609 ? 128.732 145.519 131.075 1.00 20.05  ? 609 PHE B CE1 1 
ATOM   6240 C CE2 . PHE B 1 609 ? 128.007 144.502 133.102 1.00 14.85  ? 609 PHE B CE2 1 
ATOM   6241 C CZ  . PHE B 1 609 ? 129.020 144.984 132.310 1.00 19.26  ? 609 PHE B CZ  1 
ATOM   6242 N N   . PHE B 1 610 ? 122.272 145.791 129.985 1.00 32.25  ? 610 PHE B N   1 
ATOM   6243 C CA  . PHE B 1 610 ? 121.149 145.412 129.143 1.00 30.59  ? 610 PHE B CA  1 
ATOM   6244 C C   . PHE B 1 610 ? 120.306 146.606 128.725 1.00 31.91  ? 610 PHE B C   1 
ATOM   6245 O O   . PHE B 1 610 ? 119.699 146.573 127.649 1.00 42.51  ? 610 PHE B O   1 
ATOM   6246 C CB  . PHE B 1 610 ? 120.322 144.356 129.864 1.00 26.42  ? 610 PHE B CB  1 
ATOM   6247 C CG  . PHE B 1 610 ? 121.156 143.251 130.427 1.00 30.34  ? 610 PHE B CG  1 
ATOM   6248 C CD1 . PHE B 1 610 ? 121.646 142.253 129.607 1.00 29.26  ? 610 PHE B CD1 1 
ATOM   6249 C CD2 . PHE B 1 610 ? 121.494 143.234 131.763 1.00 32.74  ? 610 PHE B CD2 1 
ATOM   6250 C CE1 . PHE B 1 610 ? 122.434 141.247 130.117 1.00 31.12  ? 610 PHE B CE1 1 
ATOM   6251 C CE2 . PHE B 1 610 ? 122.281 142.233 132.273 1.00 32.45  ? 610 PHE B CE2 1 
ATOM   6252 C CZ  . PHE B 1 610 ? 122.750 141.237 131.451 1.00 34.12  ? 610 PHE B CZ  1 
ATOM   6253 N N   . ARG B 1 611 ? 120.279 147.680 129.518 1.00 26.36  ? 611 ARG B N   1 
ATOM   6254 C CA  . ARG B 1 611 ? 119.608 148.890 129.060 1.00 31.74  ? 611 ARG B CA  1 
ATOM   6255 C C   . ARG B 1 611 ? 120.281 149.453 127.819 1.00 38.46  ? 611 ARG B C   1 
ATOM   6256 O O   . ARG B 1 611 ? 119.607 149.803 126.845 1.00 40.12  ? 611 ARG B O   1 
ATOM   6257 C CB  . ARG B 1 611 ? 119.582 149.940 130.163 1.00 31.90  ? 611 ARG B CB  1 
ATOM   6258 C CG  . ARG B 1 611 ? 119.060 151.277 129.684 1.00 30.73  ? 611 ARG B CG  1 
ATOM   6259 C CD  . ARG B 1 611 ? 117.569 151.227 129.438 1.00 34.50  ? 611 ARG B CD  1 
ATOM   6260 N NE  . ARG B 1 611 ? 117.116 152.355 128.636 1.00 40.54  ? 611 ARG B NE  1 
ATOM   6261 C CZ  . ARG B 1 611 ? 115.852 152.734 128.523 1.00 43.89  ? 611 ARG B CZ  1 
ATOM   6262 N NH1 . ARG B 1 611 ? 114.884 152.110 129.172 1.00 40.89  ? 611 ARG B NH1 1 
ATOM   6263 N NH2 . ARG B 1 611 ? 115.552 153.771 127.747 1.00 49.72  ? 611 ARG B NH2 1 
ATOM   6264 N N   . LEU B 1 612 ? 121.613 149.533 127.821 1.00 35.91  ? 612 LEU B N   1 
ATOM   6265 C CA  . LEU B 1 612 ? 122.289 150.034 126.632 1.00 37.61  ? 612 LEU B CA  1 
ATOM   6266 C C   . LEU B 1 612 ? 122.293 149.010 125.506 1.00 42.46  ? 612 LEU B C   1 
ATOM   6267 O O   . LEU B 1 612 ? 122.355 149.393 124.335 1.00 46.91  ? 612 LEU B O   1 
ATOM   6268 C CB  . LEU B 1 612 ? 123.713 150.473 126.966 1.00 34.14  ? 612 LEU B CB  1 
ATOM   6269 C CG  . LEU B 1 612 ? 123.817 151.930 127.427 1.00 31.51  ? 612 LEU B CG  1 
ATOM   6270 C CD1 . LEU B 1 612 ? 123.397 152.087 128.881 1.00 38.07  ? 612 LEU B CD1 1 
ATOM   6271 C CD2 . LEU B 1 612 ? 125.212 152.470 127.203 1.00 37.11  ? 612 LEU B CD2 1 
ATOM   6272 N N   . GLU B 1 613 ? 122.218 147.718 125.829 1.00 42.17  ? 613 GLU B N   1 
ATOM   6273 C CA  . GLU B 1 613 ? 122.042 146.717 124.782 1.00 39.54  ? 613 GLU B CA  1 
ATOM   6274 C C   . GLU B 1 613 ? 120.715 146.906 124.061 1.00 46.06  ? 613 GLU B C   1 
ATOM   6275 O O   . GLU B 1 613 ? 120.648 146.800 122.832 1.00 54.19  ? 613 GLU B O   1 
ATOM   6276 C CB  . GLU B 1 613 ? 122.127 145.312 125.369 1.00 35.50  ? 613 GLU B CB  1 
ATOM   6277 C CG  . GLU B 1 613 ? 122.067 144.221 124.321 1.00 50.61  ? 613 GLU B CG  1 
ATOM   6278 C CD  . GLU B 1 613 ? 121.773 142.857 124.907 1.00 56.49  ? 613 GLU B CD  1 
ATOM   6279 O OE1 . GLU B 1 613 ? 120.996 142.777 125.880 1.00 49.20  ? 613 GLU B OE1 1 
ATOM   6280 O OE2 . GLU B 1 613 ? 122.320 141.861 124.394 1.00 59.89  ? 613 GLU B OE2 1 
ATOM   6281 N N   . ASN B 1 614 ? 119.645 147.182 124.809 1.00 45.86  ? 614 ASN B N   1 
ATOM   6282 C CA  . ASN B 1 614 ? 118.346 147.407 124.186 1.00 43.50  ? 614 ASN B CA  1 
ATOM   6283 C C   . ASN B 1 614 ? 118.285 148.754 123.476 1.00 50.39  ? 614 ASN B C   1 
ATOM   6284 O O   . ASN B 1 614 ? 117.621 148.875 122.441 1.00 58.65  ? 614 ASN B O   1 
ATOM   6285 C CB  . ASN B 1 614 ? 117.238 147.303 125.231 1.00 43.47  ? 614 ASN B CB  1 
ATOM   6286 C CG  . ASN B 1 614 ? 115.882 147.039 124.615 1.00 55.00  ? 614 ASN B CG  1 
ATOM   6287 O OD1 . ASN B 1 614 ? 115.784 146.601 123.470 1.00 63.35  ? 614 ASN B OD1 1 
ATOM   6288 N ND2 . ASN B 1 614 ? 114.825 147.300 125.373 1.00 48.35  ? 614 ASN B ND2 1 
ATOM   6289 N N   . GLU B 1 615 ? 118.951 149.776 124.018 1.00 47.51  ? 615 GLU B N   1 
ATOM   6290 C CA  . GLU B 1 615 ? 119.028 151.062 123.330 1.00 42.67  ? 615 GLU B CA  1 
ATOM   6291 C C   . GLU B 1 615 ? 119.766 150.934 122.006 1.00 50.55  ? 615 GLU B C   1 
ATOM   6292 O O   . GLU B 1 615 ? 119.361 151.525 120.999 1.00 59.78  ? 615 GLU B O   1 
ATOM   6293 C CB  . GLU B 1 615 ? 119.722 152.092 124.218 1.00 44.47  ? 615 GLU B CB  1 
ATOM   6294 C CG  . GLU B 1 615 ? 118.890 152.576 125.385 1.00 55.01  ? 615 GLU B CG  1 
ATOM   6295 C CD  . GLU B 1 615 ? 117.958 153.705 125.004 1.00 67.71  ? 615 GLU B CD  1 
ATOM   6296 O OE1 . GLU B 1 615 ? 118.104 154.244 123.888 1.00 73.50  ? 615 GLU B OE1 1 
ATOM   6297 O OE2 . GLU B 1 615 ? 117.081 154.055 125.819 1.00 67.40  ? 615 GLU B OE2 1 
ATOM   6298 N N   . HIS B 1 616 ? 120.860 150.173 121.994 1.00 53.84  ? 616 HIS B N   1 
ATOM   6299 C CA  . HIS B 1 616 ? 121.655 149.995 120.787 1.00 54.59  ? 616 HIS B CA  1 
ATOM   6300 C C   . HIS B 1 616 ? 120.955 149.113 119.762 1.00 57.31  ? 616 HIS B C   1 
ATOM   6301 O O   . HIS B 1 616 ? 121.134 149.311 118.555 1.00 60.80  ? 616 HIS B O   1 
ATOM   6302 C CB  . HIS B 1 616 ? 123.018 149.405 121.158 1.00 49.35  ? 616 HIS B CB  1 
ATOM   6303 C CG  . HIS B 1 616 ? 123.738 148.767 120.012 1.00 59.45  ? 616 HIS B CG  1 
ATOM   6304 N ND1 . HIS B 1 616 ? 124.154 149.476 118.906 1.00 65.98  ? 616 HIS B ND1 1 
ATOM   6305 C CD2 . HIS B 1 616 ? 124.120 147.485 119.802 1.00 59.73  ? 616 HIS B CD2 1 
ATOM   6306 C CE1 . HIS B 1 616 ? 124.759 148.658 118.064 1.00 65.64  ? 616 HIS B CE1 1 
ATOM   6307 N NE2 . HIS B 1 616 ? 124.751 147.444 118.584 1.00 62.33  ? 616 HIS B NE2 1 
ATOM   6308 N N   . LEU B 1 617 ? 120.148 148.157 120.214 1.00 57.30  ? 617 LEU B N   1 
ATOM   6309 C CA  . LEU B 1 617 ? 119.557 147.164 119.330 1.00 57.66  ? 617 LEU B CA  1 
ATOM   6310 C C   . LEU B 1 617 ? 118.169 147.538 118.834 1.00 59.90  ? 617 LEU B C   1 
ATOM   6311 O O   . LEU B 1 617 ? 117.962 147.620 117.619 1.00 73.01  ? 617 LEU B O   1 
ATOM   6312 C CB  . LEU B 1 617 ? 119.485 145.812 120.044 1.00 59.90  ? 617 LEU B CB  1 
ATOM   6313 C CG  . LEU B 1 617 ? 120.013 144.593 119.293 1.00 67.58  ? 617 LEU B CG  1 
ATOM   6314 C CD1 . LEU B 1 617 ? 121.341 144.913 118.637 1.00 70.86  ? 617 LEU B CD1 1 
ATOM   6315 C CD2 . LEU B 1 617 ? 120.163 143.430 120.250 1.00 64.44  ? 617 LEU B CD2 1 
ATOM   6316 N N   . ASN B 1 618 ? 117.216 147.777 119.736 1.00 57.53  ? 618 ASN B N   1 
ATOM   6317 C CA  . ASN B 1 618 ? 115.838 148.038 119.343 1.00 64.00  ? 618 ASN B CA  1 
ATOM   6318 C C   . ASN B 1 618 ? 115.440 149.500 119.497 1.00 69.64  ? 618 ASN B C   1 
ATOM   6319 O O   . ASN B 1 618 ? 114.281 149.840 119.234 1.00 77.40  ? 618 ASN B O   1 
ATOM   6320 C CB  . ASN B 1 618 ? 114.875 147.157 120.146 1.00 63.19  ? 618 ASN B CB  1 
ATOM   6321 C CG  . ASN B 1 618 ? 115.001 145.691 119.796 1.00 73.78  ? 618 ASN B CG  1 
ATOM   6322 O OD1 . ASN B 1 618 ? 114.433 145.227 118.808 1.00 74.87  ? 618 ASN B OD1 1 
ATOM   6323 N ND2 . ASN B 1 618 ? 115.743 144.951 120.608 1.00 75.96  ? 618 ASN B ND2 1 
ATOM   6324 N N   . ASN B 1 619 ? 116.365 150.367 119.906 1.00 69.62  ? 619 ASN B N   1 
ATOM   6325 C CA  . ASN B 1 619 ? 116.097 151.794 120.081 1.00 72.60  ? 619 ASN B CA  1 
ATOM   6326 C C   . ASN B 1 619 ? 114.943 152.025 121.055 1.00 83.48  ? 619 ASN B C   1 
ATOM   6327 O O   . ASN B 1 619 ? 113.954 152.693 120.746 1.00 95.44  ? 619 ASN B O   1 
ATOM   6328 C CB  . ASN B 1 619 ? 115.828 152.471 118.735 1.00 76.35  ? 619 ASN B CB  1 
ATOM   6329 C CG  . ASN B 1 619 ? 115.722 153.980 118.850 1.00 84.59  ? 619 ASN B CG  1 
ATOM   6330 O OD1 . ASN B 1 619 ? 116.191 154.574 119.819 1.00 81.20  ? 619 ASN B OD1 1 
ATOM   6331 N ND2 . ASN B 1 619 ? 115.097 154.605 117.861 1.00 92.72  ? 619 ASN B ND2 1 
ATOM   6332 N N   . CYS B 1 620 ? 115.067 151.450 122.249 1.00 48.78  ? 620 CYS B N   1 
ATOM   6333 C CA  . CYS B 1 620 ? 114.097 151.726 123.299 1.00 48.28  ? 620 CYS B CA  1 
ATOM   6334 C C   . CYS B 1 620 ? 114.299 153.150 123.799 1.00 51.10  ? 620 CYS B C   1 
ATOM   6335 O O   . CYS B 1 620 ? 115.329 153.769 123.516 1.00 50.68  ? 620 CYS B O   1 
ATOM   6336 C CB  . CYS B 1 620 ? 114.224 150.723 124.446 1.00 54.11  ? 620 CYS B CB  1 
ATOM   6337 S SG  . CYS B 1 620 ? 115.734 150.869 125.417 1.00 64.55  ? 620 CYS B SG  1 
ATOM   6338 N N   . GLY B 1 621 ? 113.322 153.689 124.521 1.00 50.63  ? 621 GLY B N   1 
ATOM   6339 C CA  . GLY B 1 621 ? 113.420 155.055 124.995 1.00 43.18  ? 621 GLY B CA  1 
ATOM   6340 C C   . GLY B 1 621 ? 113.051 156.066 123.930 1.00 42.17  ? 621 GLY B C   1 
ATOM   6341 O O   . GLY B 1 621 ? 112.664 157.196 124.242 1.00 39.33  ? 621 GLY B O   1 
ATOM   6342 N N   . GLU B 1 622 ? 113.177 155.662 122.665 1.00 44.17  ? 622 GLU B N   1 
ATOM   6343 C CA  . GLU B 1 622 ? 112.780 156.475 121.517 1.00 42.61  ? 622 GLU B CA  1 
ATOM   6344 C C   . GLU B 1 622 ? 113.515 157.812 121.480 1.00 40.84  ? 622 GLU B C   1 
ATOM   6345 O O   . GLU B 1 622 ? 112.924 158.849 121.168 1.00 40.26  ? 622 GLU B O   1 
ATOM   6346 C CB  . GLU B 1 622 ? 111.265 156.692 121.500 1.00 43.66  ? 622 GLU B CB  1 
ATOM   6347 C CG  . GLU B 1 622 ? 110.466 155.401 121.536 1.00 43.30  ? 622 GLU B CG  1 
ATOM   6348 C CD  . GLU B 1 622 ? 109.031 155.614 121.969 1.00 48.04  ? 622 GLU B CD  1 
ATOM   6349 O OE1 . GLU B 1 622 ? 108.682 156.758 122.328 1.00 48.54  ? 622 GLU B OE1 1 
ATOM   6350 O OE2 . GLU B 1 622 ? 108.252 154.639 121.954 1.00 47.09  ? 622 GLU B OE2 1 
ATOM   6351 N N   . PHE B 1 623 ? 114.810 157.801 121.796 1.00 41.11  ? 623 PHE B N   1 
ATOM   6352 C CA  . PHE B 1 623 ? 115.619 159.010 121.706 1.00 37.50  ? 623 PHE B CA  1 
ATOM   6353 C C   . PHE B 1 623 ? 116.156 159.185 120.292 1.00 44.49  ? 623 PHE B C   1 
ATOM   6354 O O   . PHE B 1 623 ? 116.824 160.180 120.000 1.00 50.08  ? 623 PHE B O   1 
ATOM   6355 C CB  . PHE B 1 623 ? 116.781 158.968 122.700 1.00 31.52  ? 623 PHE B CB  1 
ATOM   6356 C CG  . PHE B 1 623 ? 116.356 158.864 124.134 1.00 34.14  ? 623 PHE B CG  1 
ATOM   6357 C CD1 . PHE B 1 623 ? 115.935 159.981 124.830 1.00 34.31  ? 623 PHE B CD1 1 
ATOM   6358 C CD2 . PHE B 1 623 ? 116.396 157.651 124.793 1.00 35.86  ? 623 PHE B CD2 1 
ATOM   6359 C CE1 . PHE B 1 623 ? 115.552 159.886 126.150 1.00 31.89  ? 623 PHE B CE1 1 
ATOM   6360 C CE2 . PHE B 1 623 ? 116.014 157.552 126.113 1.00 31.59  ? 623 PHE B CE2 1 
ATOM   6361 C CZ  . PHE B 1 623 ? 115.590 158.670 126.791 1.00 29.51  ? 623 PHE B CZ  1 
ATOM   6362 N N   . ARG B 1 624 ? 115.867 158.221 119.419 1.00 45.20  ? 624 ARG B N   1 
ATOM   6363 C CA  . ARG B 1 624 ? 116.302 158.234 118.021 1.00 44.57  ? 624 ARG B CA  1 
ATOM   6364 C C   . ARG B 1 624 ? 117.817 158.360 117.883 1.00 48.11  ? 624 ARG B C   1 
ATOM   6365 O O   . ARG B 1 624 ? 118.516 157.364 117.703 1.00 50.23  ? 624 ARG B O   1 
ATOM   6366 C CB  . ARG B 1 624 ? 115.609 159.364 117.254 1.00 47.43  ? 624 ARG B CB  1 
ATOM   6367 C CG  . ARG B 1 624 ? 116.008 159.465 115.790 1.00 49.49  ? 624 ARG B CG  1 
ATOM   6368 C CD  . ARG B 1 624 ? 115.715 158.179 115.038 1.00 51.73  ? 624 ARG B CD  1 
ATOM   6369 N NE  . ARG B 1 624 ? 114.292 157.862 115.023 1.00 52.24  ? 624 ARG B NE  1 
ATOM   6370 C CZ  . ARG B 1 624 ? 113.773 156.776 114.467 1.00 52.65  ? 624 ARG B CZ  1 
ATOM   6371 N NH1 . ARG B 1 624 ? 114.535 155.875 113.867 1.00 52.70  ? 624 ARG B NH1 1 
ATOM   6372 N NH2 . ARG B 1 624 ? 112.458 156.588 114.514 1.00 48.52  ? 624 ARG B NH2 1 
HETATM 6373 O O12 . PC1 C 2 .   ? 167.904 137.278 127.995 1.00 70.71  ? 801 PC1 A O12 1 
HETATM 6374 P P   . PC1 C 2 .   ? 166.419 137.264 128.105 1.00 85.55  ? 801 PC1 A P   1 
HETATM 6375 O O14 . PC1 C 2 .   ? 165.537 138.348 127.586 1.00 69.52  ? 801 PC1 A O14 1 
HETATM 6376 O O13 . PC1 C 2 .   ? 165.818 135.876 127.444 1.00 68.99  ? 801 PC1 A O13 1 
HETATM 6377 C C11 . PC1 C 2 .   ? 165.850 135.744 126.043 1.00 77.25  ? 801 PC1 A C11 1 
HETATM 6378 C C12 . PC1 C 2 .   ? 165.164 134.424 125.724 1.00 82.30  ? 801 PC1 A C12 1 
HETATM 6379 N N   . PC1 C 2 .   ? 166.056 133.228 125.556 1.00 84.08  ? 801 PC1 A N   1 
HETATM 6380 C C13 . PC1 C 2 .   ? 166.202 132.497 126.839 1.00 70.30  ? 801 PC1 A C13 1 
HETATM 6381 C C14 . PC1 C 2 .   ? 165.410 132.311 124.575 1.00 78.59  ? 801 PC1 A C14 1 
HETATM 6382 C C15 . PC1 C 2 .   ? 167.404 133.606 125.047 1.00 75.70  ? 801 PC1 A C15 1 
HETATM 6383 O O11 . PC1 C 2 .   ? 166.155 137.034 129.702 1.00 63.27  ? 801 PC1 A O11 1 
HETATM 6384 C C1  . PC1 C 2 .   ? 167.271 136.984 130.559 1.00 52.07  ? 801 PC1 A C1  1 
HETATM 6385 C C2  . PC1 C 2 .   ? 167.260 138.178 131.491 1.00 50.53  ? 801 PC1 A C2  1 
HETATM 6386 O O21 . PC1 C 2 .   ? 166.158 138.119 132.396 1.00 55.46  ? 801 PC1 A O21 1 
HETATM 6387 C C21 . PC1 C 2 .   ? 166.253 137.346 133.472 1.00 50.11  ? 801 PC1 A C21 1 
HETATM 6388 O O22 . PC1 C 2 .   ? 167.279 136.837 133.839 1.00 46.77  ? 801 PC1 A O22 1 
HETATM 6389 C C22 . PC1 C 2 .   ? 164.919 137.200 134.145 1.00 47.95  ? 801 PC1 A C22 1 
HETATM 6390 C C23 . PC1 C 2 .   ? 164.745 135.890 134.889 1.00 41.60  ? 801 PC1 A C23 1 
HETATM 6391 C C24 . PC1 C 2 .   ? 164.572 136.138 136.378 1.00 35.34  ? 801 PC1 A C24 1 
HETATM 6392 C C25 . PC1 C 2 .   ? 165.743 136.890 136.988 1.00 29.61  ? 801 PC1 A C25 1 
HETATM 6393 C C26 . PC1 C 2 .   ? 165.608 137.048 138.494 1.00 32.77  ? 801 PC1 A C26 1 
HETATM 6394 C C27 . PC1 C 2 .   ? 164.878 135.891 139.162 1.00 38.04  ? 801 PC1 A C27 1 
HETATM 6395 C C28 . PC1 C 2 .   ? 165.077 135.879 140.669 1.00 42.63  ? 801 PC1 A C28 1 
HETATM 6396 C C29 . PC1 C 2 .   ? 166.546 135.947 141.057 1.00 46.80  ? 801 PC1 A C29 1 
HETATM 6397 C C2A . PC1 C 2 .   ? 166.833 135.324 142.415 1.00 53.81  ? 801 PC1 A C2A 1 
HETATM 6398 C C2B . PC1 C 2 .   ? 168.270 134.844 142.553 1.00 49.64  ? 801 PC1 A C2B 1 
HETATM 6399 C C2C . PC1 C 2 .   ? 168.401 133.654 143.490 1.00 56.04  ? 801 PC1 A C2C 1 
HETATM 6400 C C2D . PC1 C 2 .   ? 168.130 134.007 144.944 1.00 60.17  ? 801 PC1 A C2D 1 
HETATM 6401 C C2E . PC1 C 2 .   ? 169.252 134.820 145.576 1.00 60.97  ? 801 PC1 A C2E 1 
HETATM 6402 C C2F . PC1 C 2 .   ? 169.214 134.820 147.098 1.00 66.43  ? 801 PC1 A C2F 1 
HETATM 6403 C C2G . PC1 C 2 .   ? 170.289 133.941 147.727 1.00 77.67  ? 801 PC1 A C2G 1 
HETATM 6404 C C2H . PC1 C 2 .   ? 170.031 132.446 147.582 1.00 79.20  ? 801 PC1 A C2H 1 
HETATM 6405 C C2I . PC1 C 2 .   ? 171.064 131.591 148.302 1.00 75.23  ? 801 PC1 A C2I 1 
HETATM 6406 C C3  . PC1 C 2 .   ? 167.139 139.494 130.747 1.00 57.70  ? 801 PC1 A C3  1 
HETATM 6407 O O31 . PC1 C 2 .   ? 168.279 139.612 129.897 1.00 68.30  ? 801 PC1 A O31 1 
HETATM 6408 C C31 . PC1 C 2 .   ? 169.145 140.604 130.104 1.00 60.23  ? 801 PC1 A C31 1 
HETATM 6409 O O32 . PC1 C 2 .   ? 168.985 141.720 129.680 1.00 49.10  ? 801 PC1 A O32 1 
HETATM 6410 C C32 . PC1 C 2 .   ? 170.330 140.148 130.908 1.00 47.91  ? 801 PC1 A C32 1 
HETATM 6411 C C33 . PC1 C 2 .   ? 170.145 140.246 132.417 1.00 44.62  ? 801 PC1 A C33 1 
HETATM 6412 C C34 . PC1 C 2 .   ? 170.421 138.914 133.101 1.00 42.25  ? 801 PC1 A C34 1 
HETATM 6413 C C35 . PC1 C 2 .   ? 170.707 139.032 134.590 1.00 32.21  ? 801 PC1 A C35 1 
HETATM 6414 C C36 . PC1 C 2 .   ? 169.446 139.103 135.436 1.00 34.47  ? 801 PC1 A C36 1 
HETATM 6415 C C37 . PC1 C 2 .   ? 169.631 138.555 136.844 1.00 38.40  ? 801 PC1 A C37 1 
HETATM 6416 C C38 . PC1 C 2 .   ? 171.042 138.760 137.379 1.00 37.38  ? 801 PC1 A C38 1 
HETATM 6417 C C39 . PC1 C 2 .   ? 171.200 138.401 138.850 1.00 42.15  ? 801 PC1 A C39 1 
HETATM 6418 C C3A . PC1 C 2 .   ? 171.173 136.901 139.106 1.00 45.14  ? 801 PC1 A C3A 1 
HETATM 6419 C C3B . PC1 C 2 .   ? 172.270 136.426 140.049 1.00 50.47  ? 801 PC1 A C3B 1 
HETATM 6420 C C3C . PC1 C 2 .   ? 172.123 136.974 141.463 1.00 55.87  ? 801 PC1 A C3C 1 
HETATM 6421 C C3D . PC1 C 2 .   ? 173.303 136.651 142.369 1.00 62.74  ? 801 PC1 A C3D 1 
HETATM 6422 C C3E . PC1 C 2 .   ? 173.493 135.157 142.598 1.00 69.60  ? 801 PC1 A C3E 1 
HETATM 6423 C C3F . PC1 C 2 .   ? 174.789 134.822 143.327 1.00 77.65  ? 801 PC1 A C3F 1 
HETATM 6424 C C3G . PC1 C 2 .   ? 174.910 133.352 143.711 1.00 86.29  ? 801 PC1 A C3G 1 
HETATM 6425 C C3H . PC1 C 2 .   ? 174.037 132.957 144.896 1.00 90.45  ? 801 PC1 A C3H 1 
HETATM 6426 C C3I . PC1 C 2 .   ? 174.426 131.611 145.492 1.00 82.86  ? 801 PC1 A C3I 1 
HETATM 6427 O O12 . PC1 D 2 .   ? 155.863 152.179 125.238 1.00 96.06  ? 802 PC1 A O12 1 
HETATM 6428 P P   . PC1 D 2 .   ? 157.097 151.536 125.777 1.00 103.32 ? 802 PC1 A P   1 
HETATM 6429 O O14 . PC1 D 2 .   ? 157.289 150.062 125.890 1.00 83.10  ? 802 PC1 A O14 1 
HETATM 6430 O O13 . PC1 D 2 .   ? 158.416 152.064 124.934 1.00 88.98  ? 802 PC1 A O13 1 
HETATM 6431 C C11 . PC1 D 2 .   ? 158.360 153.300 124.266 1.00 94.76  ? 802 PC1 A C11 1 
HETATM 6432 C C12 . PC1 D 2 .   ? 158.332 152.938 122.787 1.00 102.61 ? 802 PC1 A C12 1 
HETATM 6433 N N   . PC1 D 2 .   ? 158.083 154.075 121.841 1.00 104.75 ? 802 PC1 A N   1 
HETATM 6434 C C13 . PC1 D 2 .   ? 158.986 155.226 122.119 1.00 99.67  ? 802 PC1 A C13 1 
HETATM 6435 C C14 . PC1 D 2 .   ? 158.359 153.580 120.463 1.00 98.01  ? 802 PC1 A C14 1 
HETATM 6436 C C15 . PC1 D 2 .   ? 156.664 154.525 121.909 1.00 93.24  ? 802 PC1 A C15 1 
HETATM 6437 O O11 . PC1 D 2 .   ? 157.362 152.259 127.225 1.00 77.79  ? 802 PC1 A O11 1 
HETATM 6438 C C1  . PC1 D 2 .   ? 156.285 152.503 128.101 1.00 62.44  ? 802 PC1 A C1  1 
HETATM 6439 C C2  . PC1 D 2 .   ? 156.867 152.822 129.462 1.00 52.30  ? 802 PC1 A C2  1 
HETATM 6440 O O21 . PC1 D 2 .   ? 155.876 153.273 130.390 1.00 49.45  ? 802 PC1 A O21 1 
HETATM 6441 C C21 . PC1 D 2 .   ? 155.223 152.395 131.146 1.00 36.91  ? 802 PC1 A C21 1 
HETATM 6442 O O22 . PC1 D 2 .   ? 154.470 151.574 130.696 1.00 36.22  ? 802 PC1 A O22 1 
HETATM 6443 C C22 . PC1 D 2 .   ? 155.543 152.568 132.604 1.00 32.24  ? 802 PC1 A C22 1 
HETATM 6444 C C23 . PC1 D 2 .   ? 156.856 151.940 133.038 1.00 31.72  ? 802 PC1 A C23 1 
HETATM 6445 C C24 . PC1 D 2 .   ? 156.879 151.640 134.531 1.00 23.60  ? 802 PC1 A C24 1 
HETATM 6446 C C25 . PC1 D 2 .   ? 157.297 152.825 135.388 1.00 20.26  ? 802 PC1 A C25 1 
HETATM 6447 C C26 . PC1 D 2 .   ? 158.562 152.559 136.192 1.00 28.12  ? 802 PC1 A C26 1 
HETATM 6448 C C27 . PC1 D 2 .   ? 158.326 152.210 137.655 1.00 29.41  ? 802 PC1 A C27 1 
HETATM 6449 C C28 . PC1 D 2 .   ? 158.362 150.712 137.923 1.00 33.75  ? 802 PC1 A C28 1 
HETATM 6450 C C29 . PC1 D 2 .   ? 158.360 150.345 139.402 1.00 36.07  ? 802 PC1 A C29 1 
HETATM 6451 C C2A . PC1 D 2 .   ? 158.759 148.897 139.663 1.00 37.85  ? 802 PC1 A C2A 1 
HETATM 6452 C C2B . PC1 D 2 .   ? 158.460 148.420 141.079 1.00 39.37  ? 802 PC1 A C2B 1 
HETATM 6453 C C2C . PC1 D 2 .   ? 159.565 148.732 142.080 1.00 33.82  ? 802 PC1 A C2C 1 
HETATM 6454 C C2D . PC1 D 2 .   ? 160.646 147.660 142.144 1.00 35.52  ? 802 PC1 A C2D 1 
HETATM 6455 C C2E . PC1 D 2 .   ? 161.538 147.771 143.374 1.00 31.54  ? 802 PC1 A C2E 1 
HETATM 6456 C C2F . PC1 D 2 .   ? 162.386 149.036 143.381 1.00 33.33  ? 802 PC1 A C2F 1 
HETATM 6457 C C2G . PC1 D 2 .   ? 163.540 148.997 144.375 1.00 32.76  ? 802 PC1 A C2G 1 
HETATM 6458 C C2H . PC1 D 2 .   ? 164.498 150.169 144.219 1.00 38.88  ? 802 PC1 A C2H 1 
HETATM 6459 C C2I . PC1 D 2 .   ? 165.466 150.296 145.385 1.00 37.78  ? 802 PC1 A C2I 1 
HETATM 6460 C C3  . PC1 D 2 .   ? 157.890 153.928 129.354 1.00 44.56  ? 802 PC1 A C3  1 
HETATM 6461 O O31 . PC1 D 2 .   ? 158.975 153.548 130.186 1.00 43.06  ? 802 PC1 A O31 1 
HETATM 6462 C C31 . PC1 D 2 .   ? 159.518 154.480 130.954 1.00 44.19  ? 802 PC1 A C31 1 
HETATM 6463 O O32 . PC1 D 2 .   ? 159.204 155.641 130.903 1.00 49.06  ? 802 PC1 A O32 1 
HETATM 6464 C C32 . PC1 D 2 .   ? 160.552 153.898 131.870 1.00 35.49  ? 802 PC1 A C32 1 
HETATM 6465 C C33 . PC1 D 2 .   ? 160.777 154.724 133.124 1.00 32.05  ? 802 PC1 A C33 1 
HETATM 6466 C C34 . PC1 D 2 .   ? 162.006 154.237 133.873 1.00 29.48  ? 802 PC1 A C34 1 
HETATM 6467 C C35 . PC1 D 2 .   ? 161.758 154.045 135.360 1.00 26.92  ? 802 PC1 A C35 1 
HETATM 6468 C C36 . PC1 D 2 .   ? 161.818 155.346 136.144 1.00 24.64  ? 802 PC1 A C36 1 
HETATM 6469 C C37 . PC1 D 2 .   ? 161.557 155.150 137.629 1.00 31.42  ? 802 PC1 A C37 1 
HETATM 6470 C C38 . PC1 D 2 .   ? 162.341 156.115 138.507 1.00 49.51  ? 802 PC1 A C38 1 
HETATM 6471 C C39 . PC1 D 2 .   ? 162.235 155.784 139.988 1.00 60.85  ? 802 PC1 A C39 1 
HETATM 6472 C C3A . PC1 D 2 .   ? 162.988 156.763 140.879 1.00 69.78  ? 802 PC1 A C3A 1 
HETATM 6473 C C3B . PC1 D 2 .   ? 162.926 156.407 142.359 1.00 78.53  ? 802 PC1 A C3B 1 
HETATM 6474 C C3C . PC1 D 2 .   ? 161.505 156.219 142.877 1.00 75.82  ? 802 PC1 A C3C 1 
HETATM 6475 C C3D . PC1 D 2 .   ? 160.715 157.514 143.021 1.00 84.01  ? 802 PC1 A C3D 1 
HETATM 6476 C C3E . PC1 D 2 .   ? 159.659 157.707 141.937 1.00 85.15  ? 802 PC1 A C3E 1 
HETATM 6477 C C3F . PC1 D 2 .   ? 159.968 158.857 140.985 1.00 87.06  ? 802 PC1 A C3F 1 
HETATM 6478 C C3G . PC1 D 2 .   ? 159.117 160.095 141.240 1.00 81.16  ? 802 PC1 A C3G 1 
HETATM 6479 C C3H . PC1 D 2 .   ? 157.621 159.808 141.233 1.00 87.12  ? 802 PC1 A C3H 1 
HETATM 6480 C C3I . PC1 D 2 .   ? 156.779 161.076 141.240 1.00 89.85  ? 802 PC1 A C3I 1 
HETATM 6481 O O12 . PC1 E 2 .   ? 133.429 161.196 126.873 1.00 83.89  ? 801 PC1 B O12 1 
HETATM 6482 P P   . PC1 E 2 .   ? 134.071 162.143 127.827 1.00 92.69  ? 801 PC1 B P   1 
HETATM 6483 O O14 . PC1 E 2 .   ? 135.523 162.478 127.803 1.00 73.81  ? 801 PC1 B O14 1 
HETATM 6484 O O13 . PC1 E 2 .   ? 133.305 163.603 127.758 1.00 83.26  ? 801 PC1 B O13 1 
HETATM 6485 C C11 . PC1 E 2 .   ? 132.454 163.877 126.672 1.00 83.27  ? 801 PC1 B C11 1 
HETATM 6486 C C12 . PC1 E 2 .   ? 133.368 164.444 125.597 1.00 92.93  ? 801 PC1 B C12 1 
HETATM 6487 N N   . PC1 E 2 .   ? 133.174 165.897 125.282 1.00 93.96  ? 801 PC1 B N   1 
HETATM 6488 C C13 . PC1 E 2 .   ? 131.914 166.123 124.522 1.00 85.29  ? 801 PC1 B C13 1 
HETATM 6489 C C14 . PC1 E 2 .   ? 134.328 166.336 124.447 1.00 90.49  ? 801 PC1 B C14 1 
HETATM 6490 C C15 . PC1 E 2 .   ? 133.156 166.719 126.524 1.00 78.72  ? 801 PC1 B C15 1 
HETATM 6491 O O11 . PC1 E 2 .   ? 133.630 161.602 129.312 1.00 68.43  ? 801 PC1 B O11 1 
HETATM 6492 C C1  . PC1 E 2 .   ? 132.272 161.567 129.685 1.00 57.34  ? 801 PC1 B C1  1 
HETATM 6493 C C2  . PC1 E 2 .   ? 132.099 160.554 130.798 1.00 59.12  ? 801 PC1 B C2  1 
HETATM 6494 O O21 . PC1 E 2 .   ? 133.087 160.712 131.819 1.00 62.01  ? 801 PC1 B O21 1 
HETATM 6495 C C21 . PC1 E 2 .   ? 132.777 161.345 132.947 1.00 54.72  ? 801 PC1 B C21 1 
HETATM 6496 O O22 . PC1 E 2 .   ? 131.720 161.886 133.139 1.00 53.82  ? 801 PC1 B O22 1 
HETATM 6497 C C22 . PC1 E 2 .   ? 133.913 161.279 133.929 1.00 45.06  ? 801 PC1 B C22 1 
HETATM 6498 C C23 . PC1 E 2 .   ? 134.205 162.586 134.644 1.00 49.34  ? 801 PC1 B C23 1 
HETATM 6499 C C24 . PC1 E 2 .   ? 134.723 162.344 136.056 1.00 43.75  ? 801 PC1 B C24 1 
HETATM 6500 C C25 . PC1 E 2 .   ? 133.743 161.545 136.900 1.00 39.16  ? 801 PC1 B C25 1 
HETATM 6501 C C26 . PC1 E 2 .   ? 134.103 161.520 138.377 1.00 37.77  ? 801 PC1 B C26 1 
HETATM 6502 C C27 . PC1 E 2 .   ? 134.406 162.896 138.950 1.00 42.30  ? 801 PC1 B C27 1 
HETATM 6503 C C28 . PC1 E 2 .   ? 134.244 162.955 140.463 1.00 54.27  ? 801 PC1 B C28 1 
HETATM 6504 C C29 . PC1 E 2 .   ? 132.793 162.899 140.924 1.00 53.10  ? 801 PC1 B C29 1 
HETATM 6505 C C2A . PC1 E 2 .   ? 132.564 163.638 142.237 1.00 61.89  ? 801 PC1 B C2A 1 
HETATM 6506 C C2B . PC1 E 2 .   ? 131.094 163.852 142.570 1.00 58.81  ? 801 PC1 B C2B 1 
HETATM 6507 C C2C . PC1 E 2 .   ? 130.874 164.777 143.761 1.00 63.00  ? 801 PC1 B C2C 1 
HETATM 6508 C C2D . PC1 E 2 .   ? 131.302 164.177 145.094 1.00 61.94  ? 801 PC1 B C2D 1 
HETATM 6509 C C2E . PC1 E 2 .   ? 130.171 164.095 146.113 1.00 61.09  ? 801 PC1 B C2E 1 
HETATM 6510 C C2F . PC1 E 2 .   ? 130.613 163.520 147.454 1.00 70.30  ? 801 PC1 B C2F 1 
HETATM 6511 C C2G . PC1 E 2 .   ? 129.466 163.213 148.409 1.00 73.49  ? 801 PC1 B C2G 1 
HETATM 6512 C C2H . PC1 E 2 .   ? 128.639 164.437 148.783 1.00 83.64  ? 801 PC1 B C2H 1 
HETATM 6513 C C2I . PC1 E 2 .   ? 129.454 165.527 149.466 1.00 77.96  ? 801 PC1 B C2I 1 
HETATM 6514 C C3  . PC1 E 2 .   ? 132.245 159.132 130.298 1.00 60.09  ? 801 PC1 B C3  1 
HETATM 6515 O O31 . PC1 E 2 .   ? 131.047 158.796 129.603 1.00 68.76  ? 801 PC1 B O31 1 
HETATM 6516 C C31 . PC1 E 2 .   ? 130.274 157.829 130.090 1.00 61.39  ? 801 PC1 B C31 1 
HETATM 6517 O O32 . PC1 E 2 .   ? 130.442 156.663 129.841 1.00 60.37  ? 801 PC1 B O32 1 
HETATM 6518 C C32 . PC1 E 2 .   ? 129.180 158.379 130.960 1.00 51.23  ? 801 PC1 B C32 1 
HETATM 6519 C C33 . PC1 E 2 .   ? 129.498 158.394 132.448 1.00 49.94  ? 801 PC1 B C33 1 
HETATM 6520 C C34 . PC1 E 2 .   ? 128.874 159.604 133.132 1.00 47.43  ? 801 PC1 B C34 1 
HETATM 6521 C C35 . PC1 E 2 .   ? 128.641 159.430 134.626 1.00 36.70  ? 801 PC1 B C35 1 
HETATM 6522 C C36 . PC1 E 2 .   ? 129.922 159.521 135.441 1.00 41.01  ? 801 PC1 B C36 1 
HETATM 6523 C C37 . PC1 E 2 .   ? 129.731 160.190 136.795 1.00 39.77  ? 801 PC1 B C37 1 
HETATM 6524 C C38 . PC1 E 2 .   ? 128.458 159.743 137.499 1.00 45.76  ? 801 PC1 B C38 1 
HETATM 6525 C C39 . PC1 E 2 .   ? 128.366 160.199 138.949 1.00 47.25  ? 801 PC1 B C39 1 
HETATM 6526 C C3A . PC1 E 2 .   ? 128.224 161.707 139.096 1.00 53.11  ? 801 PC1 B C3A 1 
HETATM 6527 C C3B . PC1 E 2 .   ? 127.137 162.120 140.079 1.00 57.97  ? 801 PC1 B C3B 1 
HETATM 6528 C C3C . PC1 E 2 .   ? 127.360 161.569 141.480 1.00 64.54  ? 801 PC1 B C3C 1 
HETATM 6529 C C3D . PC1 E 2 .   ? 126.236 161.898 142.453 1.00 66.47  ? 801 PC1 B C3D 1 
HETATM 6530 C C3E . PC1 E 2 .   ? 125.904 163.384 142.504 1.00 61.46  ? 801 PC1 B C3E 1 
HETATM 6531 C C3F . PC1 E 2 .   ? 125.018 163.768 143.683 1.00 62.36  ? 801 PC1 B C3F 1 
HETATM 6532 C C3G . PC1 E 2 .   ? 124.824 165.274 143.809 1.00 75.57  ? 801 PC1 B C3G 1 
HETATM 6533 C C3H . PC1 E 2 .   ? 124.121 165.694 145.095 1.00 77.74  ? 801 PC1 B C3H 1 
HETATM 6534 C C3I . PC1 E 2 .   ? 123.908 167.199 145.184 1.00 74.25  ? 801 PC1 B C3I 1 
HETATM 6535 O O12 . PC1 F 2 .   ? 143.763 146.191 126.219 1.00 100.78 ? 802 PC1 B O12 1 
HETATM 6536 P P   . PC1 F 2 .   ? 142.494 146.873 126.607 1.00 112.08 ? 802 PC1 B P   1 
HETATM 6537 O O14 . PC1 F 2 .   ? 142.167 148.287 126.263 1.00 100.22 ? 802 PC1 B O14 1 
HETATM 6538 O O13 . PC1 F 2 .   ? 141.204 145.997 126.066 1.00 106.30 ? 802 PC1 B O13 1 
HETATM 6539 C C11 . PC1 F 2 .   ? 141.321 144.600 125.957 1.00 99.18  ? 802 PC1 B C11 1 
HETATM 6540 C C12 . PC1 F 2 .   ? 140.902 144.281 124.528 1.00 114.08 ? 802 PC1 B C12 1 
HETATM 6541 N N   . PC1 F 2 .   ? 141.999 144.232 123.505 1.00 119.47 ? 802 PC1 B N   1 
HETATM 6542 C C13 . PC1 F 2 .   ? 141.552 143.501 122.288 1.00 108.55 ? 802 PC1 B C13 1 
HETATM 6543 C C14 . PC1 F 2 .   ? 142.336 145.632 123.118 1.00 113.18 ? 802 PC1 B C14 1 
HETATM 6544 C C15 . PC1 F 2 .   ? 143.223 143.581 124.052 1.00 115.70 ? 802 PC1 B C15 1 
HETATM 6545 O O11 . PC1 F 2 .   ? 142.347 146.622 128.220 1.00 88.23  ? 802 PC1 B O11 1 
HETATM 6546 C C1  . PC1 F 2 .   ? 143.502 146.576 129.026 1.00 72.90  ? 802 PC1 B C1  1 
HETATM 6547 C C2  . PC1 F 2 .   ? 143.121 145.983 130.364 1.00 64.15  ? 802 PC1 B C2  1 
HETATM 6548 O O21 . PC1 F 2 .   ? 144.243 145.881 131.243 1.00 54.40  ? 802 PC1 B O21 1 
HETATM 6549 C C21 . PC1 F 2 .   ? 144.236 146.583 132.373 1.00 53.72  ? 802 PC1 B C21 1 
HETATM 6550 O O22 . PC1 F 2 .   ? 144.826 147.620 132.513 1.00 64.85  ? 802 PC1 B O22 1 
HETATM 6551 C C22 . PC1 F 2 .   ? 143.406 145.916 133.432 1.00 38.13  ? 802 PC1 B C22 1 
HETATM 6552 C C23 . PC1 F 2 .   ? 142.164 146.697 133.821 1.00 36.35  ? 802 PC1 B C23 1 
HETATM 6553 C C24 . PC1 F 2 .   ? 142.309 147.316 135.203 1.00 27.28  ? 802 PC1 B C24 1 
HETATM 6554 C C25 . PC1 F 2 .   ? 142.164 146.302 136.326 1.00 23.53  ? 802 PC1 B C25 1 
HETATM 6555 C C26 . PC1 F 2 .   ? 140.763 146.263 136.914 1.00 21.56  ? 802 PC1 B C26 1 
HETATM 6556 C C27 . PC1 F 2 .   ? 140.704 146.686 138.375 1.00 27.80  ? 802 PC1 B C27 1 
HETATM 6557 C C28 . PC1 F 2 .   ? 140.417 148.172 138.548 1.00 37.58  ? 802 PC1 B C28 1 
HETATM 6558 C C29 . PC1 F 2 .   ? 140.150 148.595 139.988 1.00 45.94  ? 802 PC1 B C29 1 
HETATM 6559 C C2A . PC1 F 2 .   ? 140.101 150.109 140.154 1.00 49.64  ? 802 PC1 B C2A 1 
HETATM 6560 C C2B . PC1 F 2 .   ? 140.656 150.601 141.485 1.00 45.17  ? 802 PC1 B C2B 1 
HETATM 6561 C C2C . PC1 F 2 .   ? 139.679 150.418 142.636 1.00 38.40  ? 802 PC1 B C2C 1 
HETATM 6562 C C2D . PC1 F 2 .   ? 138.271 150.885 142.297 1.00 41.87  ? 802 PC1 B C2D 1 
HETATM 6563 C C2E . PC1 F 2 .   ? 137.301 150.746 143.461 1.00 49.95  ? 802 PC1 B C2E 1 
HETATM 6564 C C2F . PC1 F 2 .   ? 137.121 149.307 143.933 1.00 59.01  ? 802 PC1 B C2F 1 
HETATM 6565 C C2G . PC1 F 2 .   ? 135.681 148.812 143.853 1.00 47.30  ? 802 PC1 B C2G 1 
HETATM 6566 C C2H . PC1 F 2 .   ? 135.002 148.660 145.207 1.00 42.58  ? 802 PC1 B C2H 1 
HETATM 6567 C C2I . PC1 F 2 .   ? 134.785 149.992 145.905 1.00 49.15  ? 802 PC1 B C2I 1 
HETATM 6568 C C3  . PC1 F 2 .   ? 142.571 144.585 130.195 1.00 61.58  ? 802 PC1 B C3  1 
HETATM 6569 O O31 . PC1 F 2 .   ? 141.191 144.722 129.881 1.00 57.78  ? 802 PC1 B O31 1 
HETATM 6570 C C31 . PC1 F 2 .   ? 140.331 143.967 130.550 1.00 55.49  ? 802 PC1 B C31 1 
HETATM 6571 O O32 . PC1 F 2 .   ? 140.167 142.797 130.316 1.00 63.67  ? 802 PC1 B O32 1 
HETATM 6572 C C32 . PC1 F 2 .   ? 139.611 144.746 131.610 1.00 43.94  ? 802 PC1 B C32 1 
HETATM 6573 C C33 . PC1 F 2 .   ? 139.100 143.873 132.745 1.00 36.25  ? 802 PC1 B C33 1 
HETATM 6574 C C34 . PC1 F 2 .   ? 137.885 144.490 133.416 1.00 28.16  ? 802 PC1 B C34 1 
HETATM 6575 C C35 . PC1 F 2 .   ? 138.038 144.622 134.923 1.00 26.34  ? 802 PC1 B C35 1 
HETATM 6576 C C36 . PC1 F 2 .   ? 137.714 143.337 135.672 1.00 27.68  ? 802 PC1 B C36 1 
HETATM 6577 C C37 . PC1 F 2 .   ? 138.143 143.380 137.131 1.00 28.05  ? 802 PC1 B C37 1 
HETATM 6578 C C38 . PC1 F 2 .   ? 137.261 142.546 138.049 1.00 32.76  ? 802 PC1 B C38 1 
HETATM 6579 C C39 . PC1 F 2 .   ? 137.526 142.817 139.523 1.00 46.55  ? 802 PC1 B C39 1 
HETATM 6580 C C3A . PC1 F 2 .   ? 136.717 141.927 140.456 1.00 57.74  ? 802 PC1 B C3A 1 
HETATM 6581 C C3B . PC1 F 2 .   ? 136.786 142.358 141.915 1.00 61.50  ? 802 PC1 B C3B 1 
HETATM 6582 C C3C . PC1 F 2 .   ? 138.211 142.507 142.432 1.00 70.57  ? 802 PC1 B C3C 1 
HETATM 6583 C C3D . PC1 F 2 .   ? 138.650 141.385 143.363 1.00 81.61  ? 802 PC1 B C3D 1 
HETATM 6584 C C3E . PC1 F 2 .   ? 139.795 140.550 142.802 1.00 79.64  ? 802 PC1 B C3E 1 
HETATM 6585 C C3F . PC1 F 2 .   ? 139.405 139.727 141.580 1.00 72.02  ? 802 PC1 B C3F 1 
HETATM 6586 C C3G . PC1 F 2 .   ? 140.580 138.990 140.949 1.00 73.40  ? 802 PC1 B C3G 1 
HETATM 6587 C C3H . PC1 F 2 .   ? 141.162 137.897 141.838 1.00 72.65  ? 802 PC1 B C3H 1 
HETATM 6588 C C3I . PC1 F 2 .   ? 142.576 138.208 142.310 1.00 71.72  ? 802 PC1 B C3I 1 
# 
