data_9J08
# 
_entry.id   9J08 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9J08         pdb_00009j08 10.2210/pdb9j08/pdb 
WWPDB D_1300050102 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-02-05 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9J08 
_pdbx_database_status.recvd_initial_deposition_date   2024-08-02 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              asfushi@mail.ecc.u-tokyo.ac.jp 
_pdbx_contact_author.name_first         Shinya 
_pdbx_contact_author.name_last          Fushinobu 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-1346-6435 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Yamada, C.'    1 0000-0003-0606-3996 
'Koseki, T.'    2 0000-0002-5398-175X 
'Fushinobu, S.' 3 0000-0003-1346-6435 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Febs J.' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1742-464X 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Identification and structural characterization of a novel acetyl xylan esterase from Aspergillus oryzae.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1111/febs.17420 
_citation.pdbx_database_id_PubMed   39876052 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Yamada, C.'    1 ?                   
primary 'Kato, T.'      2 ?                   
primary 'Shiono, Y.'    3 ?                   
primary 'Koseki, T.'    4 0000-0002-5398-175X 
primary 'Fushinobu, S.' 5 0000-0003-1346-6435 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'feruloyl esterase'                      35590.398 1   3.1.1.73 ? ? ? 
2 non-polymer nat 2-acetamido-2-deoxy-beta-D-glucopyranose 221.208   2   ?        ? ? ? 
3 non-polymer syn 'ACETATE ION'                            59.044    1   ?        ? ? ? 
4 non-polymer syn 'SUCCINIC ACID'                          118.088   1   ?        ? ? ? 
5 water       nat water                                    18.015    245 ?        ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MKFLSVILLTTTAGLASAAGSAGCGQPLPPSQNPGGSSYGVNFTLSAGTQRFYRIHIPSNYNVNTPTPLIFSFHGRGKTA
ESQEKLSQFSNEDWNPDAIAVYPQGLNKEWQGDPHSKDVDDIAFTMEMLDYFQEKFCIDSTRVYAAGKSNGGGFTNLLAC
DPTASTRIAAFAPVSGAYYQDVSEEACHPTTVPIKCSPGRPSIPILEFHGTADKTIPYGGGGRRGECLPSIPHFVREWSK
RLGYGLHNTTKELYDGNVQEYQYGNGDNRGIVTHYRIGGLGHDWPSVRPNSDNPNGTYLDATPIIVKFFKQWVLPGSSED
NQSEAR
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MKFLSVILLTTTAGLASAAGSAGCGQPLPPSQNPGGSSYGVNFTLSAGTQRFYRIHIPSNYNVNTPTPLIFSFHGRGKTA
ESQEKLSQFSNEDWNPDAIAVYPQGLNKEWQGDPHSKDVDDIAFTMEMLDYFQEKFCIDSTRVYAAGKSNGGGFTNLLAC
DPTASTRIAAFAPVSGAYYQDVSEEACHPTTVPIKCSPGRPSIPILEFHGTADKTIPYGGGGRRGECLPSIPHFVREWSK
RLGYGLHNTTKELYDGNVQEYQYGNGDNRGIVTHYRIGGLGHDWPSVRPNSDNPNGTYLDATPIIVKFFKQWVLPGSSED
NQSEAR
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 2-acetamido-2-deoxy-beta-D-glucopyranose NAG 
3 'ACETATE ION'                            ACT 
4 'SUCCINIC ACID'                          SIN 
5 water                                    HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   LYS n 
1 3   PHE n 
1 4   LEU n 
1 5   SER n 
1 6   VAL n 
1 7   ILE n 
1 8   LEU n 
1 9   LEU n 
1 10  THR n 
1 11  THR n 
1 12  THR n 
1 13  ALA n 
1 14  GLY n 
1 15  LEU n 
1 16  ALA n 
1 17  SER n 
1 18  ALA n 
1 19  ALA n 
1 20  GLY n 
1 21  SER n 
1 22  ALA n 
1 23  GLY n 
1 24  CYS n 
1 25  GLY n 
1 26  GLN n 
1 27  PRO n 
1 28  LEU n 
1 29  PRO n 
1 30  PRO n 
1 31  SER n 
1 32  GLN n 
1 33  ASN n 
1 34  PRO n 
1 35  GLY n 
1 36  GLY n 
1 37  SER n 
1 38  SER n 
1 39  TYR n 
1 40  GLY n 
1 41  VAL n 
1 42  ASN n 
1 43  PHE n 
1 44  THR n 
1 45  LEU n 
1 46  SER n 
1 47  ALA n 
1 48  GLY n 
1 49  THR n 
1 50  GLN n 
1 51  ARG n 
1 52  PHE n 
1 53  TYR n 
1 54  ARG n 
1 55  ILE n 
1 56  HIS n 
1 57  ILE n 
1 58  PRO n 
1 59  SER n 
1 60  ASN n 
1 61  TYR n 
1 62  ASN n 
1 63  VAL n 
1 64  ASN n 
1 65  THR n 
1 66  PRO n 
1 67  THR n 
1 68  PRO n 
1 69  LEU n 
1 70  ILE n 
1 71  PHE n 
1 72  SER n 
1 73  PHE n 
1 74  HIS n 
1 75  GLY n 
1 76  ARG n 
1 77  GLY n 
1 78  LYS n 
1 79  THR n 
1 80  ALA n 
1 81  GLU n 
1 82  SER n 
1 83  GLN n 
1 84  GLU n 
1 85  LYS n 
1 86  LEU n 
1 87  SER n 
1 88  GLN n 
1 89  PHE n 
1 90  SER n 
1 91  ASN n 
1 92  GLU n 
1 93  ASP n 
1 94  TRP n 
1 95  ASN n 
1 96  PRO n 
1 97  ASP n 
1 98  ALA n 
1 99  ILE n 
1 100 ALA n 
1 101 VAL n 
1 102 TYR n 
1 103 PRO n 
1 104 GLN n 
1 105 GLY n 
1 106 LEU n 
1 107 ASN n 
1 108 LYS n 
1 109 GLU n 
1 110 TRP n 
1 111 GLN n 
1 112 GLY n 
1 113 ASP n 
1 114 PRO n 
1 115 HIS n 
1 116 SER n 
1 117 LYS n 
1 118 ASP n 
1 119 VAL n 
1 120 ASP n 
1 121 ASP n 
1 122 ILE n 
1 123 ALA n 
1 124 PHE n 
1 125 THR n 
1 126 MET n 
1 127 GLU n 
1 128 MET n 
1 129 LEU n 
1 130 ASP n 
1 131 TYR n 
1 132 PHE n 
1 133 GLN n 
1 134 GLU n 
1 135 LYS n 
1 136 PHE n 
1 137 CYS n 
1 138 ILE n 
1 139 ASP n 
1 140 SER n 
1 141 THR n 
1 142 ARG n 
1 143 VAL n 
1 144 TYR n 
1 145 ALA n 
1 146 ALA n 
1 147 GLY n 
1 148 LYS n 
1 149 SER n 
1 150 ASN n 
1 151 GLY n 
1 152 GLY n 
1 153 GLY n 
1 154 PHE n 
1 155 THR n 
1 156 ASN n 
1 157 LEU n 
1 158 LEU n 
1 159 ALA n 
1 160 CYS n 
1 161 ASP n 
1 162 PRO n 
1 163 THR n 
1 164 ALA n 
1 165 SER n 
1 166 THR n 
1 167 ARG n 
1 168 ILE n 
1 169 ALA n 
1 170 ALA n 
1 171 PHE n 
1 172 ALA n 
1 173 PRO n 
1 174 VAL n 
1 175 SER n 
1 176 GLY n 
1 177 ALA n 
1 178 TYR n 
1 179 TYR n 
1 180 GLN n 
1 181 ASP n 
1 182 VAL n 
1 183 SER n 
1 184 GLU n 
1 185 GLU n 
1 186 ALA n 
1 187 CYS n 
1 188 HIS n 
1 189 PRO n 
1 190 THR n 
1 191 THR n 
1 192 VAL n 
1 193 PRO n 
1 194 ILE n 
1 195 LYS n 
1 196 CYS n 
1 197 SER n 
1 198 PRO n 
1 199 GLY n 
1 200 ARG n 
1 201 PRO n 
1 202 SER n 
1 203 ILE n 
1 204 PRO n 
1 205 ILE n 
1 206 LEU n 
1 207 GLU n 
1 208 PHE n 
1 209 HIS n 
1 210 GLY n 
1 211 THR n 
1 212 ALA n 
1 213 ASP n 
1 214 LYS n 
1 215 THR n 
1 216 ILE n 
1 217 PRO n 
1 218 TYR n 
1 219 GLY n 
1 220 GLY n 
1 221 GLY n 
1 222 GLY n 
1 223 ARG n 
1 224 ARG n 
1 225 GLY n 
1 226 GLU n 
1 227 CYS n 
1 228 LEU n 
1 229 PRO n 
1 230 SER n 
1 231 ILE n 
1 232 PRO n 
1 233 HIS n 
1 234 PHE n 
1 235 VAL n 
1 236 ARG n 
1 237 GLU n 
1 238 TRP n 
1 239 SER n 
1 240 LYS n 
1 241 ARG n 
1 242 LEU n 
1 243 GLY n 
1 244 TYR n 
1 245 GLY n 
1 246 LEU n 
1 247 HIS n 
1 248 ASN n 
1 249 THR n 
1 250 THR n 
1 251 LYS n 
1 252 GLU n 
1 253 LEU n 
1 254 TYR n 
1 255 ASP n 
1 256 GLY n 
1 257 ASN n 
1 258 VAL n 
1 259 GLN n 
1 260 GLU n 
1 261 TYR n 
1 262 GLN n 
1 263 TYR n 
1 264 GLY n 
1 265 ASN n 
1 266 GLY n 
1 267 ASP n 
1 268 ASN n 
1 269 ARG n 
1 270 GLY n 
1 271 ILE n 
1 272 VAL n 
1 273 THR n 
1 274 HIS n 
1 275 TYR n 
1 276 ARG n 
1 277 ILE n 
1 278 GLY n 
1 279 GLY n 
1 280 LEU n 
1 281 GLY n 
1 282 HIS n 
1 283 ASP n 
1 284 TRP n 
1 285 PRO n 
1 286 SER n 
1 287 VAL n 
1 288 ARG n 
1 289 PRO n 
1 290 ASN n 
1 291 SER n 
1 292 ASP n 
1 293 ASN n 
1 294 PRO n 
1 295 ASN n 
1 296 GLY n 
1 297 THR n 
1 298 TYR n 
1 299 LEU n 
1 300 ASP n 
1 301 ALA n 
1 302 THR n 
1 303 PRO n 
1 304 ILE n 
1 305 ILE n 
1 306 VAL n 
1 307 LYS n 
1 308 PHE n 
1 309 PHE n 
1 310 LYS n 
1 311 GLN n 
1 312 TRP n 
1 313 VAL n 
1 314 LEU n 
1 315 PRO n 
1 316 GLY n 
1 317 SER n 
1 318 SER n 
1 319 GLU n 
1 320 ASP n 
1 321 ASN n 
1 322 GLN n 
1 323 SER n 
1 324 GLU n 
1 325 ALA n 
1 326 ARG n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   326 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 AO090005000945 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Aspergillus oryzae RIB40' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     510516 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Komagataella pastoris' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     4922 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               KM71H 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          plasmid 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       pPICZB 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ACT non-polymer                  . 'ACETATE ION'                            ? 'C2 H3 O2 -1'    59.044  
ALA 'L-peptide linking'          y ALANINE                                  ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking'          y ARGININE                                 ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking'          y ASPARAGINE                               ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking'          y 'ASPARTIC ACID'                          ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking'          y CYSTEINE                                 ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking'          y GLUTAMINE                                ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking'          y 'GLUTAMIC ACID'                          ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'            y GLYCINE                                  ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking'          y HISTIDINE                                ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer                  . WATER                                    ? 'H2 O'           18.015  
ILE 'L-peptide linking'          y ISOLEUCINE                               ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking'          y LEUCINE                                  ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking'          y LYSINE                                   ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking'          y METHIONINE                               ? 'C5 H11 N O2 S'  149.211 
NAG 'D-saccharide, beta linking' . 2-acetamido-2-deoxy-beta-D-glucopyranose 
;N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE
;
'C8 H15 N O6'    221.208 
PHE 'L-peptide linking'          y PHENYLALANINE                            ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking'          y PROLINE                                  ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking'          y SERINE                                   ? 'C3 H7 N O3'     105.093 
SIN non-polymer                  . 'SUCCINIC ACID'                          ? 'C4 H6 O4'       118.088 
THR 'L-peptide linking'          y THREONINE                                ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking'          y TRYPTOPHAN                               ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking'          y TYROSINE                                 ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking'          y VALINE                                   ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
NAG 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DGlcpNAcb                      
NAG 'COMMON NAME'                         GMML     1.0 N-acetyl-b-D-glucopyranosamine 
NAG 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-GlcpNAc                    
NAG 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 GlcNAc                         
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   LYS 2   2   ?   ?   ?   A . n 
A 1 3   PHE 3   3   ?   ?   ?   A . n 
A 1 4   LEU 4   4   ?   ?   ?   A . n 
A 1 5   SER 5   5   ?   ?   ?   A . n 
A 1 6   VAL 6   6   ?   ?   ?   A . n 
A 1 7   ILE 7   7   ?   ?   ?   A . n 
A 1 8   LEU 8   8   ?   ?   ?   A . n 
A 1 9   LEU 9   9   ?   ?   ?   A . n 
A 1 10  THR 10  10  ?   ?   ?   A . n 
A 1 11  THR 11  11  ?   ?   ?   A . n 
A 1 12  THR 12  12  ?   ?   ?   A . n 
A 1 13  ALA 13  13  ?   ?   ?   A . n 
A 1 14  GLY 14  14  ?   ?   ?   A . n 
A 1 15  LEU 15  15  ?   ?   ?   A . n 
A 1 16  ALA 16  16  ?   ?   ?   A . n 
A 1 17  SER 17  17  ?   ?   ?   A . n 
A 1 18  ALA 18  18  ?   ?   ?   A . n 
A 1 19  ALA 19  19  19  ALA ALA A . n 
A 1 20  GLY 20  20  20  GLY GLY A . n 
A 1 21  SER 21  21  21  SER SER A . n 
A 1 22  ALA 22  22  22  ALA ALA A . n 
A 1 23  GLY 23  23  23  GLY GLY A . n 
A 1 24  CYS 24  24  24  CYS CYS A . n 
A 1 25  GLY 25  25  25  GLY GLY A . n 
A 1 26  GLN 26  26  26  GLN GLN A . n 
A 1 27  PRO 27  27  27  PRO PRO A . n 
A 1 28  LEU 28  28  28  LEU LEU A . n 
A 1 29  PRO 29  29  29  PRO PRO A . n 
A 1 30  PRO 30  30  30  PRO PRO A . n 
A 1 31  SER 31  31  31  SER SER A . n 
A 1 32  GLN 32  32  32  GLN GLN A . n 
A 1 33  ASN 33  33  ?   ?   ?   A . n 
A 1 34  PRO 34  34  34  PRO PRO A . n 
A 1 35  GLY 35  35  35  GLY GLY A . n 
A 1 36  GLY 36  36  36  GLY GLY A . n 
A 1 37  SER 37  37  37  SER SER A . n 
A 1 38  SER 38  38  38  SER SER A . n 
A 1 39  TYR 39  39  39  TYR TYR A . n 
A 1 40  GLY 40  40  40  GLY GLY A . n 
A 1 41  VAL 41  41  41  VAL VAL A . n 
A 1 42  ASN 42  42  42  ASN ASN A . n 
A 1 43  PHE 43  43  43  PHE PHE A . n 
A 1 44  THR 44  44  44  THR THR A . n 
A 1 45  LEU 45  45  45  LEU LEU A . n 
A 1 46  SER 46  46  46  SER SER A . n 
A 1 47  ALA 47  47  47  ALA ALA A . n 
A 1 48  GLY 48  48  48  GLY GLY A . n 
A 1 49  THR 49  49  49  THR THR A . n 
A 1 50  GLN 50  50  50  GLN GLN A . n 
A 1 51  ARG 51  51  51  ARG ARG A . n 
A 1 52  PHE 52  52  52  PHE PHE A . n 
A 1 53  TYR 53  53  53  TYR TYR A . n 
A 1 54  ARG 54  54  54  ARG ARG A . n 
A 1 55  ILE 55  55  55  ILE ILE A . n 
A 1 56  HIS 56  56  56  HIS HIS A . n 
A 1 57  ILE 57  57  57  ILE ILE A . n 
A 1 58  PRO 58  58  58  PRO PRO A . n 
A 1 59  SER 59  59  59  SER SER A . n 
A 1 60  ASN 60  60  60  ASN ASN A . n 
A 1 61  TYR 61  61  61  TYR TYR A . n 
A 1 62  ASN 62  62  62  ASN ASN A . n 
A 1 63  VAL 63  63  63  VAL VAL A . n 
A 1 64  ASN 64  64  64  ASN ASN A . n 
A 1 65  THR 65  65  65  THR THR A . n 
A 1 66  PRO 66  66  66  PRO PRO A . n 
A 1 67  THR 67  67  67  THR THR A . n 
A 1 68  PRO 68  68  68  PRO PRO A . n 
A 1 69  LEU 69  69  69  LEU LEU A . n 
A 1 70  ILE 70  70  70  ILE ILE A . n 
A 1 71  PHE 71  71  71  PHE PHE A . n 
A 1 72  SER 72  72  72  SER SER A . n 
A 1 73  PHE 73  73  73  PHE PHE A . n 
A 1 74  HIS 74  74  74  HIS HIS A . n 
A 1 75  GLY 75  75  75  GLY GLY A . n 
A 1 76  ARG 76  76  76  ARG ARG A . n 
A 1 77  GLY 77  77  77  GLY GLY A . n 
A 1 78  LYS 78  78  78  LYS LYS A . n 
A 1 79  THR 79  79  79  THR THR A . n 
A 1 80  ALA 80  80  80  ALA ALA A . n 
A 1 81  GLU 81  81  81  GLU GLU A . n 
A 1 82  SER 82  82  82  SER SER A . n 
A 1 83  GLN 83  83  83  GLN GLN A . n 
A 1 84  GLU 84  84  84  GLU GLU A . n 
A 1 85  LYS 85  85  85  LYS LYS A . n 
A 1 86  LEU 86  86  86  LEU LEU A . n 
A 1 87  SER 87  87  87  SER SER A . n 
A 1 88  GLN 88  88  88  GLN GLN A . n 
A 1 89  PHE 89  89  89  PHE PHE A . n 
A 1 90  SER 90  90  90  SER SER A . n 
A 1 91  ASN 91  91  91  ASN ASN A . n 
A 1 92  GLU 92  92  92  GLU GLU A . n 
A 1 93  ASP 93  93  93  ASP ASP A . n 
A 1 94  TRP 94  94  94  TRP TRP A . n 
A 1 95  ASN 95  95  95  ASN ASN A . n 
A 1 96  PRO 96  96  96  PRO PRO A . n 
A 1 97  ASP 97  97  97  ASP ASP A . n 
A 1 98  ALA 98  98  98  ALA ALA A . n 
A 1 99  ILE 99  99  99  ILE ILE A . n 
A 1 100 ALA 100 100 100 ALA ALA A . n 
A 1 101 VAL 101 101 101 VAL VAL A . n 
A 1 102 TYR 102 102 102 TYR TYR A . n 
A 1 103 PRO 103 103 103 PRO PRO A . n 
A 1 104 GLN 104 104 104 GLN GLN A . n 
A 1 105 GLY 105 105 105 GLY GLY A . n 
A 1 106 LEU 106 106 106 LEU LEU A . n 
A 1 107 ASN 107 107 107 ASN ASN A . n 
A 1 108 LYS 108 108 108 LYS LYS A . n 
A 1 109 GLU 109 109 109 GLU GLU A . n 
A 1 110 TRP 110 110 110 TRP TRP A . n 
A 1 111 GLN 111 111 111 GLN GLN A . n 
A 1 112 GLY 112 112 112 GLY GLY A . n 
A 1 113 ASP 113 113 113 ASP ASP A . n 
A 1 114 PRO 114 114 114 PRO PRO A . n 
A 1 115 HIS 115 115 115 HIS HIS A . n 
A 1 116 SER 116 116 116 SER SER A . n 
A 1 117 LYS 117 117 117 LYS LYS A . n 
A 1 118 ASP 118 118 118 ASP ASP A . n 
A 1 119 VAL 119 119 119 VAL VAL A . n 
A 1 120 ASP 120 120 120 ASP ASP A . n 
A 1 121 ASP 121 121 121 ASP ASP A . n 
A 1 122 ILE 122 122 122 ILE ILE A . n 
A 1 123 ALA 123 123 123 ALA ALA A . n 
A 1 124 PHE 124 124 124 PHE PHE A . n 
A 1 125 THR 125 125 125 THR THR A . n 
A 1 126 MET 126 126 126 MET MET A . n 
A 1 127 GLU 127 127 127 GLU GLU A . n 
A 1 128 MET 128 128 128 MET MET A . n 
A 1 129 LEU 129 129 129 LEU LEU A . n 
A 1 130 ASP 130 130 130 ASP ASP A . n 
A 1 131 TYR 131 131 131 TYR TYR A . n 
A 1 132 PHE 132 132 132 PHE PHE A . n 
A 1 133 GLN 133 133 133 GLN GLN A . n 
A 1 134 GLU 134 134 134 GLU GLU A . n 
A 1 135 LYS 135 135 135 LYS LYS A . n 
A 1 136 PHE 136 136 136 PHE PHE A . n 
A 1 137 CYS 137 137 137 CYS CYS A . n 
A 1 138 ILE 138 138 138 ILE ILE A . n 
A 1 139 ASP 139 139 139 ASP ASP A . n 
A 1 140 SER 140 140 140 SER SER A . n 
A 1 141 THR 141 141 141 THR THR A . n 
A 1 142 ARG 142 142 142 ARG ARG A . n 
A 1 143 VAL 143 143 143 VAL VAL A . n 
A 1 144 TYR 144 144 144 TYR TYR A . n 
A 1 145 ALA 145 145 145 ALA ALA A . n 
A 1 146 ALA 146 146 146 ALA ALA A . n 
A 1 147 GLY 147 147 147 GLY GLY A . n 
A 1 148 LYS 148 148 148 LYS LYS A . n 
A 1 149 SER 149 149 149 SER SER A . n 
A 1 150 ASN 150 150 150 ASN ASN A . n 
A 1 151 GLY 151 151 151 GLY GLY A . n 
A 1 152 GLY 152 152 152 GLY GLY A . n 
A 1 153 GLY 153 153 153 GLY GLY A . n 
A 1 154 PHE 154 154 154 PHE PHE A . n 
A 1 155 THR 155 155 155 THR THR A . n 
A 1 156 ASN 156 156 156 ASN ASN A . n 
A 1 157 LEU 157 157 157 LEU LEU A . n 
A 1 158 LEU 158 158 158 LEU LEU A . n 
A 1 159 ALA 159 159 159 ALA ALA A . n 
A 1 160 CYS 160 160 160 CYS CYS A . n 
A 1 161 ASP 161 161 161 ASP ASP A . n 
A 1 162 PRO 162 162 162 PRO PRO A . n 
A 1 163 THR 163 163 163 THR THR A . n 
A 1 164 ALA 164 164 164 ALA ALA A . n 
A 1 165 SER 165 165 165 SER SER A . n 
A 1 166 THR 166 166 166 THR THR A . n 
A 1 167 ARG 167 167 167 ARG ARG A . n 
A 1 168 ILE 168 168 168 ILE ILE A . n 
A 1 169 ALA 169 169 169 ALA ALA A . n 
A 1 170 ALA 170 170 170 ALA ALA A . n 
A 1 171 PHE 171 171 171 PHE PHE A . n 
A 1 172 ALA 172 172 172 ALA ALA A . n 
A 1 173 PRO 173 173 173 PRO PRO A . n 
A 1 174 VAL 174 174 174 VAL VAL A . n 
A 1 175 SER 175 175 175 SER SER A . n 
A 1 176 GLY 176 176 176 GLY GLY A . n 
A 1 177 ALA 177 177 177 ALA ALA A . n 
A 1 178 TYR 178 178 178 TYR TYR A . n 
A 1 179 TYR 179 179 179 TYR TYR A . n 
A 1 180 GLN 180 180 180 GLN GLN A . n 
A 1 181 ASP 181 181 181 ASP ASP A . n 
A 1 182 VAL 182 182 182 VAL VAL A . n 
A 1 183 SER 183 183 183 SER SER A . n 
A 1 184 GLU 184 184 184 GLU GLU A . n 
A 1 185 GLU 185 185 185 GLU GLU A . n 
A 1 186 ALA 186 186 186 ALA ALA A . n 
A 1 187 CYS 187 187 187 CYS CYS A . n 
A 1 188 HIS 188 188 188 HIS HIS A . n 
A 1 189 PRO 189 189 189 PRO PRO A . n 
A 1 190 THR 190 190 190 THR THR A . n 
A 1 191 THR 191 191 191 THR THR A . n 
A 1 192 VAL 192 192 192 VAL VAL A . n 
A 1 193 PRO 193 193 193 PRO PRO A . n 
A 1 194 ILE 194 194 194 ILE ILE A . n 
A 1 195 LYS 195 195 195 LYS LYS A . n 
A 1 196 CYS 196 196 196 CYS CYS A . n 
A 1 197 SER 197 197 197 SER SER A . n 
A 1 198 PRO 198 198 198 PRO PRO A . n 
A 1 199 GLY 199 199 199 GLY GLY A . n 
A 1 200 ARG 200 200 200 ARG ARG A . n 
A 1 201 PRO 201 201 201 PRO PRO A . n 
A 1 202 SER 202 202 202 SER SER A . n 
A 1 203 ILE 203 203 203 ILE ILE A . n 
A 1 204 PRO 204 204 204 PRO PRO A . n 
A 1 205 ILE 205 205 205 ILE ILE A . n 
A 1 206 LEU 206 206 206 LEU LEU A . n 
A 1 207 GLU 207 207 207 GLU GLU A . n 
A 1 208 PHE 208 208 208 PHE PHE A . n 
A 1 209 HIS 209 209 209 HIS HIS A . n 
A 1 210 GLY 210 210 210 GLY GLY A . n 
A 1 211 THR 211 211 211 THR THR A . n 
A 1 212 ALA 212 212 212 ALA ALA A . n 
A 1 213 ASP 213 213 213 ASP ASP A . n 
A 1 214 LYS 214 214 214 LYS LYS A . n 
A 1 215 THR 215 215 215 THR THR A . n 
A 1 216 ILE 216 216 216 ILE ILE A . n 
A 1 217 PRO 217 217 217 PRO PRO A . n 
A 1 218 TYR 218 218 218 TYR TYR A . n 
A 1 219 GLY 219 219 219 GLY GLY A . n 
A 1 220 GLY 220 220 220 GLY GLY A . n 
A 1 221 GLY 221 221 221 GLY GLY A . n 
A 1 222 GLY 222 222 222 GLY GLY A . n 
A 1 223 ARG 223 223 223 ARG ARG A . n 
A 1 224 ARG 224 224 224 ARG ARG A . n 
A 1 225 GLY 225 225 225 GLY GLY A . n 
A 1 226 GLU 226 226 226 GLU GLU A . n 
A 1 227 CYS 227 227 227 CYS CYS A . n 
A 1 228 LEU 228 228 228 LEU LEU A . n 
A 1 229 PRO 229 229 229 PRO PRO A . n 
A 1 230 SER 230 230 230 SER SER A . n 
A 1 231 ILE 231 231 231 ILE ILE A . n 
A 1 232 PRO 232 232 232 PRO PRO A . n 
A 1 233 HIS 233 233 233 HIS HIS A . n 
A 1 234 PHE 234 234 234 PHE PHE A . n 
A 1 235 VAL 235 235 235 VAL VAL A . n 
A 1 236 ARG 236 236 236 ARG ARG A . n 
A 1 237 GLU 237 237 237 GLU GLU A . n 
A 1 238 TRP 238 238 238 TRP TRP A . n 
A 1 239 SER 239 239 239 SER SER A . n 
A 1 240 LYS 240 240 240 LYS LYS A . n 
A 1 241 ARG 241 241 241 ARG ARG A . n 
A 1 242 LEU 242 242 242 LEU LEU A . n 
A 1 243 GLY 243 243 243 GLY GLY A . n 
A 1 244 TYR 244 244 244 TYR TYR A . n 
A 1 245 GLY 245 245 245 GLY GLY A . n 
A 1 246 LEU 246 246 246 LEU LEU A . n 
A 1 247 HIS 247 247 247 HIS HIS A . n 
A 1 248 ASN 248 248 248 ASN ASN A . n 
A 1 249 THR 249 249 249 THR THR A . n 
A 1 250 THR 250 250 250 THR THR A . n 
A 1 251 LYS 251 251 251 LYS LYS A . n 
A 1 252 GLU 252 252 252 GLU GLU A . n 
A 1 253 LEU 253 253 253 LEU LEU A . n 
A 1 254 TYR 254 254 254 TYR TYR A . n 
A 1 255 ASP 255 255 255 ASP ASP A . n 
A 1 256 GLY 256 256 256 GLY GLY A . n 
A 1 257 ASN 257 257 257 ASN ASN A . n 
A 1 258 VAL 258 258 258 VAL VAL A . n 
A 1 259 GLN 259 259 259 GLN GLN A . n 
A 1 260 GLU 260 260 260 GLU GLU A . n 
A 1 261 TYR 261 261 261 TYR TYR A . n 
A 1 262 GLN 262 262 262 GLN GLN A . n 
A 1 263 TYR 263 263 263 TYR TYR A . n 
A 1 264 GLY 264 264 264 GLY GLY A . n 
A 1 265 ASN 265 265 265 ASN ASN A . n 
A 1 266 GLY 266 266 266 GLY GLY A . n 
A 1 267 ASP 267 267 267 ASP ASP A . n 
A 1 268 ASN 268 268 268 ASN ASN A . n 
A 1 269 ARG 269 269 269 ARG ARG A . n 
A 1 270 GLY 270 270 270 GLY GLY A . n 
A 1 271 ILE 271 271 271 ILE ILE A . n 
A 1 272 VAL 272 272 272 VAL VAL A . n 
A 1 273 THR 273 273 273 THR THR A . n 
A 1 274 HIS 274 274 274 HIS HIS A . n 
A 1 275 TYR 275 275 275 TYR TYR A . n 
A 1 276 ARG 276 276 276 ARG ARG A . n 
A 1 277 ILE 277 277 277 ILE ILE A . n 
A 1 278 GLY 278 278 278 GLY GLY A . n 
A 1 279 GLY 279 279 279 GLY GLY A . n 
A 1 280 LEU 280 280 280 LEU LEU A . n 
A 1 281 GLY 281 281 281 GLY GLY A . n 
A 1 282 HIS 282 282 282 HIS HIS A . n 
A 1 283 ASP 283 283 283 ASP ASP A . n 
A 1 284 TRP 284 284 284 TRP TRP A . n 
A 1 285 PRO 285 285 285 PRO PRO A . n 
A 1 286 SER 286 286 286 SER SER A . n 
A 1 287 VAL 287 287 287 VAL VAL A . n 
A 1 288 ARG 288 288 288 ARG ARG A . n 
A 1 289 PRO 289 289 289 PRO PRO A . n 
A 1 290 ASN 290 290 290 ASN ASN A . n 
A 1 291 SER 291 291 291 SER SER A . n 
A 1 292 ASP 292 292 292 ASP ASP A . n 
A 1 293 ASN 293 293 293 ASN ASN A . n 
A 1 294 PRO 294 294 294 PRO PRO A . n 
A 1 295 ASN 295 295 295 ASN ASN A . n 
A 1 296 GLY 296 296 296 GLY GLY A . n 
A 1 297 THR 297 297 297 THR THR A . n 
A 1 298 TYR 298 298 298 TYR TYR A . n 
A 1 299 LEU 299 299 299 LEU LEU A . n 
A 1 300 ASP 300 300 300 ASP ASP A . n 
A 1 301 ALA 301 301 301 ALA ALA A . n 
A 1 302 THR 302 302 302 THR THR A . n 
A 1 303 PRO 303 303 303 PRO PRO A . n 
A 1 304 ILE 304 304 304 ILE ILE A . n 
A 1 305 ILE 305 305 305 ILE ILE A . n 
A 1 306 VAL 306 306 306 VAL VAL A . n 
A 1 307 LYS 307 307 307 LYS LYS A . n 
A 1 308 PHE 308 308 308 PHE PHE A . n 
A 1 309 PHE 309 309 309 PHE PHE A . n 
A 1 310 LYS 310 310 310 LYS LYS A . n 
A 1 311 GLN 311 311 311 GLN GLN A . n 
A 1 312 TRP 312 312 312 TRP TRP A . n 
A 1 313 VAL 313 313 313 VAL VAL A . n 
A 1 314 LEU 314 314 314 LEU LEU A . n 
A 1 315 PRO 315 315 315 PRO PRO A . n 
A 1 316 GLY 316 316 316 GLY GLY A . n 
A 1 317 SER 317 317 317 SER SER A . n 
A 1 318 SER 318 318 ?   ?   ?   A . n 
A 1 319 GLU 319 319 ?   ?   ?   A . n 
A 1 320 ASP 320 320 ?   ?   ?   A . n 
A 1 321 ASN 321 321 ?   ?   ?   A . n 
A 1 322 GLN 322 322 ?   ?   ?   A . n 
A 1 323 SER 323 323 ?   ?   ?   A . n 
A 1 324 GLU 324 324 ?   ?   ?   A . n 
A 1 325 ALA 325 325 ?   ?   ?   A . n 
A 1 326 ARG 326 326 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        SIN 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   SIN 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 NAG 1   401 403 NAG NAG A . 
C 2 NAG 1   402 404 NAG NAG A . 
D 3 ACT 1   403 405 ACT ACT A . 
E 4 SIN 1   404 406 SIN SIN A . 
F 5 HOH 1   501 231 HOH HOH A . 
F 5 HOH 2   502 193 HOH HOH A . 
F 5 HOH 3   503 148 HOH HOH A . 
F 5 HOH 4   504 240 HOH HOH A . 
F 5 HOH 5   505 245 HOH HOH A . 
F 5 HOH 6   506 80  HOH HOH A . 
F 5 HOH 7   507 3   HOH HOH A . 
F 5 HOH 8   508 171 HOH HOH A . 
F 5 HOH 9   509 20  HOH HOH A . 
F 5 HOH 10  510 184 HOH HOH A . 
F 5 HOH 11  511 73  HOH HOH A . 
F 5 HOH 12  512 92  HOH HOH A . 
F 5 HOH 13  513 88  HOH HOH A . 
F 5 HOH 14  514 159 HOH HOH A . 
F 5 HOH 15  515 117 HOH HOH A . 
F 5 HOH 16  516 218 HOH HOH A . 
F 5 HOH 17  517 125 HOH HOH A . 
F 5 HOH 18  518 209 HOH HOH A . 
F 5 HOH 19  519 242 HOH HOH A . 
F 5 HOH 20  520 85  HOH HOH A . 
F 5 HOH 21  521 214 HOH HOH A . 
F 5 HOH 22  522 226 HOH HOH A . 
F 5 HOH 23  523 196 HOH HOH A . 
F 5 HOH 24  524 116 HOH HOH A . 
F 5 HOH 25  525 238 HOH HOH A . 
F 5 HOH 26  526 153 HOH HOH A . 
F 5 HOH 27  527 56  HOH HOH A . 
F 5 HOH 28  528 221 HOH HOH A . 
F 5 HOH 29  529 57  HOH HOH A . 
F 5 HOH 30  530 243 HOH HOH A . 
F 5 HOH 31  531 98  HOH HOH A . 
F 5 HOH 32  532 173 HOH HOH A . 
F 5 HOH 33  533 230 HOH HOH A . 
F 5 HOH 34  534 225 HOH HOH A . 
F 5 HOH 35  535 223 HOH HOH A . 
F 5 HOH 36  536 23  HOH HOH A . 
F 5 HOH 37  537 114 HOH HOH A . 
F 5 HOH 38  538 160 HOH HOH A . 
F 5 HOH 39  539 161 HOH HOH A . 
F 5 HOH 40  540 76  HOH HOH A . 
F 5 HOH 41  541 54  HOH HOH A . 
F 5 HOH 42  542 136 HOH HOH A . 
F 5 HOH 43  543 202 HOH HOH A . 
F 5 HOH 44  544 235 HOH HOH A . 
F 5 HOH 45  545 64  HOH HOH A . 
F 5 HOH 46  546 163 HOH HOH A . 
F 5 HOH 47  547 247 HOH HOH A . 
F 5 HOH 48  548 146 HOH HOH A . 
F 5 HOH 49  549 46  HOH HOH A . 
F 5 HOH 50  550 35  HOH HOH A . 
F 5 HOH 51  551 241 HOH HOH A . 
F 5 HOH 52  552 246 HOH HOH A . 
F 5 HOH 53  553 33  HOH HOH A . 
F 5 HOH 54  554 89  HOH HOH A . 
F 5 HOH 55  555 182 HOH HOH A . 
F 5 HOH 56  556 120 HOH HOH A . 
F 5 HOH 57  557 109 HOH HOH A . 
F 5 HOH 58  558 11  HOH HOH A . 
F 5 HOH 59  559 94  HOH HOH A . 
F 5 HOH 60  560 8   HOH HOH A . 
F 5 HOH 61  561 42  HOH HOH A . 
F 5 HOH 62  562 232 HOH HOH A . 
F 5 HOH 63  563 65  HOH HOH A . 
F 5 HOH 64  564 228 HOH HOH A . 
F 5 HOH 65  565 84  HOH HOH A . 
F 5 HOH 66  566 21  HOH HOH A . 
F 5 HOH 67  567 39  HOH HOH A . 
F 5 HOH 68  568 134 HOH HOH A . 
F 5 HOH 69  569 217 HOH HOH A . 
F 5 HOH 70  570 144 HOH HOH A . 
F 5 HOH 71  571 6   HOH HOH A . 
F 5 HOH 72  572 131 HOH HOH A . 
F 5 HOH 73  573 216 HOH HOH A . 
F 5 HOH 74  574 181 HOH HOH A . 
F 5 HOH 75  575 234 HOH HOH A . 
F 5 HOH 76  576 55  HOH HOH A . 
F 5 HOH 77  577 63  HOH HOH A . 
F 5 HOH 78  578 12  HOH HOH A . 
F 5 HOH 79  579 179 HOH HOH A . 
F 5 HOH 80  580 112 HOH HOH A . 
F 5 HOH 81  581 190 HOH HOH A . 
F 5 HOH 82  582 135 HOH HOH A . 
F 5 HOH 83  583 17  HOH HOH A . 
F 5 HOH 84  584 34  HOH HOH A . 
F 5 HOH 85  585 19  HOH HOH A . 
F 5 HOH 86  586 87  HOH HOH A . 
F 5 HOH 87  587 236 HOH HOH A . 
F 5 HOH 88  588 95  HOH HOH A . 
F 5 HOH 89  589 1   HOH HOH A . 
F 5 HOH 90  590 220 HOH HOH A . 
F 5 HOH 91  591 43  HOH HOH A . 
F 5 HOH 92  592 195 HOH HOH A . 
F 5 HOH 93  593 2   HOH HOH A . 
F 5 HOH 94  594 14  HOH HOH A . 
F 5 HOH 95  595 78  HOH HOH A . 
F 5 HOH 96  596 141 HOH HOH A . 
F 5 HOH 97  597 26  HOH HOH A . 
F 5 HOH 98  598 83  HOH HOH A . 
F 5 HOH 99  599 24  HOH HOH A . 
F 5 HOH 100 600 48  HOH HOH A . 
F 5 HOH 101 601 72  HOH HOH A . 
F 5 HOH 102 602 7   HOH HOH A . 
F 5 HOH 103 603 233 HOH HOH A . 
F 5 HOH 104 604 5   HOH HOH A . 
F 5 HOH 105 605 168 HOH HOH A . 
F 5 HOH 106 606 13  HOH HOH A . 
F 5 HOH 107 607 79  HOH HOH A . 
F 5 HOH 108 608 59  HOH HOH A . 
F 5 HOH 109 609 150 HOH HOH A . 
F 5 HOH 110 610 132 HOH HOH A . 
F 5 HOH 111 611 67  HOH HOH A . 
F 5 HOH 112 612 151 HOH HOH A . 
F 5 HOH 113 613 18  HOH HOH A . 
F 5 HOH 114 614 91  HOH HOH A . 
F 5 HOH 115 615 38  HOH HOH A . 
F 5 HOH 116 616 81  HOH HOH A . 
F 5 HOH 117 617 128 HOH HOH A . 
F 5 HOH 118 618 29  HOH HOH A . 
F 5 HOH 119 619 237 HOH HOH A . 
F 5 HOH 120 620 27  HOH HOH A . 
F 5 HOH 121 621 4   HOH HOH A . 
F 5 HOH 122 622 68  HOH HOH A . 
F 5 HOH 123 623 37  HOH HOH A . 
F 5 HOH 124 624 36  HOH HOH A . 
F 5 HOH 125 625 176 HOH HOH A . 
F 5 HOH 126 626 102 HOH HOH A . 
F 5 HOH 127 627 69  HOH HOH A . 
F 5 HOH 128 628 61  HOH HOH A . 
F 5 HOH 129 629 126 HOH HOH A . 
F 5 HOH 130 630 93  HOH HOH A . 
F 5 HOH 131 631 113 HOH HOH A . 
F 5 HOH 132 632 183 HOH HOH A . 
F 5 HOH 133 633 22  HOH HOH A . 
F 5 HOH 134 634 177 HOH HOH A . 
F 5 HOH 135 635 167 HOH HOH A . 
F 5 HOH 136 636 142 HOH HOH A . 
F 5 HOH 137 637 124 HOH HOH A . 
F 5 HOH 138 638 9   HOH HOH A . 
F 5 HOH 139 639 103 HOH HOH A . 
F 5 HOH 140 640 244 HOH HOH A . 
F 5 HOH 141 641 106 HOH HOH A . 
F 5 HOH 142 642 53  HOH HOH A . 
F 5 HOH 143 643 222 HOH HOH A . 
F 5 HOH 144 644 157 HOH HOH A . 
F 5 HOH 145 645 50  HOH HOH A . 
F 5 HOH 146 646 71  HOH HOH A . 
F 5 HOH 147 647 239 HOH HOH A . 
F 5 HOH 148 648 215 HOH HOH A . 
F 5 HOH 149 649 31  HOH HOH A . 
F 5 HOH 150 650 180 HOH HOH A . 
F 5 HOH 151 651 139 HOH HOH A . 
F 5 HOH 152 652 30  HOH HOH A . 
F 5 HOH 153 653 107 HOH HOH A . 
F 5 HOH 154 654 130 HOH HOH A . 
F 5 HOH 155 655 100 HOH HOH A . 
F 5 HOH 156 656 28  HOH HOH A . 
F 5 HOH 157 657 219 HOH HOH A . 
F 5 HOH 158 658 82  HOH HOH A . 
F 5 HOH 159 659 60  HOH HOH A . 
F 5 HOH 160 660 16  HOH HOH A . 
F 5 HOH 161 661 47  HOH HOH A . 
F 5 HOH 162 662 192 HOH HOH A . 
F 5 HOH 163 663 213 HOH HOH A . 
F 5 HOH 164 664 45  HOH HOH A . 
F 5 HOH 165 665 119 HOH HOH A . 
F 5 HOH 166 666 194 HOH HOH A . 
F 5 HOH 167 667 66  HOH HOH A . 
F 5 HOH 168 668 145 HOH HOH A . 
F 5 HOH 169 669 105 HOH HOH A . 
F 5 HOH 170 670 32  HOH HOH A . 
F 5 HOH 171 671 201 HOH HOH A . 
F 5 HOH 172 672 133 HOH HOH A . 
F 5 HOH 173 673 137 HOH HOH A . 
F 5 HOH 174 674 41  HOH HOH A . 
F 5 HOH 175 675 25  HOH HOH A . 
F 5 HOH 176 676 49  HOH HOH A . 
F 5 HOH 177 677 149 HOH HOH A . 
F 5 HOH 178 678 227 HOH HOH A . 
F 5 HOH 179 679 169 HOH HOH A . 
F 5 HOH 180 680 77  HOH HOH A . 
F 5 HOH 181 681 115 HOH HOH A . 
F 5 HOH 182 682 40  HOH HOH A . 
F 5 HOH 183 683 147 HOH HOH A . 
F 5 HOH 184 684 111 HOH HOH A . 
F 5 HOH 185 685 74  HOH HOH A . 
F 5 HOH 186 686 122 HOH HOH A . 
F 5 HOH 187 687 118 HOH HOH A . 
F 5 HOH 188 688 104 HOH HOH A . 
F 5 HOH 189 689 166 HOH HOH A . 
F 5 HOH 190 690 127 HOH HOH A . 
F 5 HOH 191 691 162 HOH HOH A . 
F 5 HOH 192 692 200 HOH HOH A . 
F 5 HOH 193 693 140 HOH HOH A . 
F 5 HOH 194 694 174 HOH HOH A . 
F 5 HOH 195 695 158 HOH HOH A . 
F 5 HOH 196 696 90  HOH HOH A . 
F 5 HOH 197 697 97  HOH HOH A . 
F 5 HOH 198 698 154 HOH HOH A . 
F 5 HOH 199 699 205 HOH HOH A . 
F 5 HOH 200 700 197 HOH HOH A . 
F 5 HOH 201 701 108 HOH HOH A . 
F 5 HOH 202 702 198 HOH HOH A . 
F 5 HOH 203 703 62  HOH HOH A . 
F 5 HOH 204 704 229 HOH HOH A . 
F 5 HOH 205 705 123 HOH HOH A . 
F 5 HOH 206 706 129 HOH HOH A . 
F 5 HOH 207 707 138 HOH HOH A . 
F 5 HOH 208 708 203 HOH HOH A . 
F 5 HOH 209 709 110 HOH HOH A . 
F 5 HOH 210 710 189 HOH HOH A . 
F 5 HOH 211 711 186 HOH HOH A . 
F 5 HOH 212 712 15  HOH HOH A . 
F 5 HOH 213 713 208 HOH HOH A . 
F 5 HOH 214 714 210 HOH HOH A . 
F 5 HOH 215 715 121 HOH HOH A . 
F 5 HOH 216 716 175 HOH HOH A . 
F 5 HOH 217 717 172 HOH HOH A . 
F 5 HOH 218 718 152 HOH HOH A . 
F 5 HOH 219 719 58  HOH HOH A . 
F 5 HOH 220 720 101 HOH HOH A . 
F 5 HOH 221 721 86  HOH HOH A . 
F 5 HOH 222 722 96  HOH HOH A . 
F 5 HOH 223 723 44  HOH HOH A . 
F 5 HOH 224 724 207 HOH HOH A . 
F 5 HOH 225 725 178 HOH HOH A . 
F 5 HOH 226 726 99  HOH HOH A . 
F 5 HOH 227 727 52  HOH HOH A . 
F 5 HOH 228 728 206 HOH HOH A . 
F 5 HOH 229 729 211 HOH HOH A . 
F 5 HOH 230 730 165 HOH HOH A . 
F 5 HOH 231 731 70  HOH HOH A . 
F 5 HOH 232 732 185 HOH HOH A . 
F 5 HOH 233 733 188 HOH HOH A . 
F 5 HOH 234 734 51  HOH HOH A . 
F 5 HOH 235 735 164 HOH HOH A . 
F 5 HOH 236 736 187 HOH HOH A . 
F 5 HOH 237 737 155 HOH HOH A . 
F 5 HOH 238 738 10  HOH HOH A . 
F 5 HOH 239 739 156 HOH HOH A . 
F 5 HOH 240 740 199 HOH HOH A . 
F 5 HOH 241 741 143 HOH HOH A . 
F 5 HOH 242 742 170 HOH HOH A . 
F 5 HOH 243 743 224 HOH HOH A . 
F 5 HOH 244 744 191 HOH HOH A . 
F 5 HOH 245 745 75  HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC  ? ? ? 5.8.0419 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .        2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .        3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? MoRDa   ? ? ? .        4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9J08 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     57.027 
_cell.length_a_esd                 ? 
_cell.length_b                     64.008 
_cell.length_b_esd                 ? 
_cell.length_c                     83.324 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9J08 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9J08 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.29 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          46.32 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              4.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M sodium acetate (pH 4.5), 20% PEG3000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293.15 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 2M-F' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2021-09-21 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.000 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SLS BEAMLINE X06DA' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.000 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   X06DA 
_diffrn_source.pdbx_synchrotron_site       SLS 
# 
_reflns.B_iso_Wilson_estimate                          11.56 
_reflns.entry_id                                       9J08 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.90 
_reflns.d_resolution_low                               47.10 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     23666 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           96.0 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                5.6 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          13.7 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                0.037 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.994 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.086 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.90 
_reflns_shell.d_res_low                                     1.94 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           4.1 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1011 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               2.0 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               0.176 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.715 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          65.8 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.219 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            0.44 
_refine.aniso_B[1][2]                            -0.00 
_refine.aniso_B[1][3]                            0.00 
_refine.aniso_B[2][2]                            -0.94 
_refine.aniso_B[2][3]                            0.00 
_refine.aniso_B[3][3]                            0.50 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               15.253 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.951 
_refine.correlation_coeff_Fo_to_Fc_free          0.929 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9J08 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.90 
_refine.ls_d_res_low                             47.10 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     22442 
_refine.ls_number_reflns_R_free                  1179 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    95.72 
_refine.ls_percent_reflns_R_free                 5.0 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.16545 
_refine.ls_R_factor_R_free                       0.19942 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.16367 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.149 
_refine.pdbx_overall_ESU_R_Free                  0.133 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             2.731 
_refine.overall_SU_ML                            0.081 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.90 
_refine_hist.d_res_low                        47.10 
_refine_hist.number_atoms_solvent             245 
_refine_hist.number_atoms_total               2589 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2304 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         40 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.009  0.012  2422 ? r_bond_refined_d             ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.016  2133 ? r_bond_other_d               ? ? 
'X-RAY DIFFRACTION' ? 1.519  1.678  3301 ? r_angle_refined_deg          ? ? 
'X-RAY DIFFRACTION' ? 0.513  1.581  4944 ? r_angle_other_deg            ? ? 
'X-RAY DIFFRACTION' ? 7.531  5.000  298  ? r_dihedral_angle_1_deg       ? ? 
'X-RAY DIFFRACTION' ? 7.494  5.000  13   ? r_dihedral_angle_2_deg       ? ? 
'X-RAY DIFFRACTION' ? 12.234 10.000 345  ? r_dihedral_angle_3_deg       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_dihedral_angle_4_deg       ? ? 
'X-RAY DIFFRACTION' ? 0.075  0.200  340  ? r_chiral_restr               ? ? 
'X-RAY DIFFRACTION' ? 0.009  0.020  2914 ? r_gen_planes_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.020  570  ? r_gen_planes_other           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbd_refined                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbd_other                  ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbtor_refined              ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbtor_other                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_xyhbond_nbd_refined        ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_xyhbond_nbd_other          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_metal_ion_refined          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_metal_ion_other            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_vdw_refined       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_vdw_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_hbond_refined     ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_hbond_other       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_metal_ion_refined ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_metal_ion_other   ? ? 
'X-RAY DIFFRACTION' ? 1.733  1.502  1193 ? r_mcbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 1.732  1.500  1192 ? r_mcbond_other               ? ? 
'X-RAY DIFFRACTION' ? 2.691  2.675  1487 ? r_mcangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 2.690  2.680  1488 ? r_mcangle_other              ? ? 
'X-RAY DIFFRACTION' ? 2.504  1.769  1229 ? r_scbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 2.500  1.769  1228 ? r_scbond_other               ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_scangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 4.010  3.125  1814 ? r_scangle_other              ? ? 
'X-RAY DIFFRACTION' ? 6.061  16.22  2778 ? r_long_range_B_refined       ? ? 
'X-RAY DIFFRACTION' ? 5.958  15.55  2704 ? r_long_range_B_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_rigid_bond_restr           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_sphericity_free            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_sphericity_bonded          ? ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       1.900 
_refine_ls_shell.d_res_low                        1.949 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             66 
_refine_ls_shell.number_reflns_R_work             1126 
_refine_ls_shell.percent_reflns_obs               66.93 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  0.193 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.221 
# 
_struct.entry_id                     9J08 
_struct.title                        'Acetyl xylan esterase B from Aspergillus oryzae (AoAXEB), succinate complex form' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9J08 
_struct_keywords.text            'Acetyl xylan esterase, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
F N N 5 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    Q2UR69_ASPOR 
_struct_ref.pdbx_db_accession          Q2UR69 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MKFLSVILLTTTAGLASAAGSAGCGQPLPPSQNPGGSSYGVNFTLSAGTQRFYRIHIPSNYNVNTPTPLIFSFHGRGKTA
ESQEKLSQFSNEDWNPDAIAVYPQGLNKEWQGDPHSKDVDDIAFTMEMLDYFQEKFCIDSTRVYAAGKSNGGGFTNLLAC
DPTASTRIAAFAPVSGAYYQDVSEEACHPTTVPIKCSPGRPSIPILEFHGTADKTIPYGGGGRRGECLPSIPHFVREWSK
RLGYGLHNTTKELYDGNVQEYQYGNGDNRGIVTHYRIGGLGHDWPSVRPNSDNPNGTYLDATPIIVKFFKQWVLPGSSED
NQSEAR
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9J08 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 326 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q2UR69 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  326 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       326 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 620   ? 
1 MORE         6     ? 
1 'SSA (A^2)'  12950 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 THR A 79  ? GLN A 88  ? THR A 79  GLN A 88  1 ? 10 
HELX_P HELX_P2 AA2 GLY A 105 ? GLU A 109 ? GLY A 105 GLU A 109 5 ? 5  
HELX_P HELX_P3 AA3 ASP A 120 ? PHE A 136 ? ASP A 120 PHE A 136 1 ? 17 
HELX_P HELX_P4 AA4 SER A 149 ? CYS A 160 ? SER A 149 CYS A 160 1 ? 12 
HELX_P HELX_P5 AA5 THR A 163 ? ARG A 167 ? THR A 163 ARG A 167 5 ? 5  
HELX_P HELX_P6 AA6 SER A 183 ? CYS A 187 ? SER A 183 CYS A 187 5 ? 5  
HELX_P HELX_P7 AA7 SER A 230 ? LYS A 240 ? SER A 230 LYS A 240 1 ? 11 
HELX_P HELX_P8 AA8 ARG A 241 ? GLY A 243 ? ARG A 241 GLY A 243 5 ? 3  
HELX_P HELX_P9 AA9 ASP A 300 ? TRP A 312 ? ASP A 300 TRP A 312 1 ? 13 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ?   ? A CYS 24  SG  ? ? ? 1_555 A CYS 137 SG ? ? A CYS 24  A CYS 137 1_555 ? ? ? ? ? ? ? 1.995 ? ?               
disulf2 disulf ?   ? A CYS 160 SG  ? ? ? 1_555 A CYS 196 SG ? ? A CYS 160 A CYS 196 1_555 ? ? ? ? ? ? ? 2.096 ? ?               
disulf3 disulf ?   ? A CYS 187 SG  ? ? ? 1_555 A CYS 227 SG ? ? A CYS 187 A CYS 227 1_555 ? ? ? ? ? ? ? 2.071 ? ?               
covale1 covale one ? A ASN 42  ND2 ? ? ? 1_555 B NAG .   C1 ? ? A ASN 42  A NAG 401 1_555 ? ? ? ? ? ? ? 1.435 ? N-Glycosylation 
covale2 covale one ? A ASN 295 ND2 ? ? ? 1_555 C NAG .   C1 ? ? A ASN 295 A NAG 402 1_555 ? ? ? ? ? ? ? 1.414 ? N-Glycosylation 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
covale ? ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 NAG B .   ? ASN A 42  ? NAG A 401 ? 1_555 ASN A 42  ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
2 NAG C .   ? ASN A 295 ? NAG A 402 ? 1_555 ASN A 295 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
3 CYS A 24  ? CYS A 137 ? CYS A 24  ? 1_555 CYS A 137 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
4 CYS A 160 ? CYS A 196 ? CYS A 160 ? 1_555 CYS A 196 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
5 CYS A 187 ? CYS A 227 ? CYS A 187 ? 1_555 CYS A 227 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 6 ? 
AA2 ? 4 ? 
AA3 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? parallel      
AA1 4 5 ? parallel      
AA1 5 6 ? parallel      
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA3 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 TYR A 39  ? THR A 44  ? TYR A 39  THR A 44  
AA1 2 GLN A 50  ? HIS A 56  ? GLN A 50  HIS A 56  
AA1 3 ILE A 99  ? PRO A 103 ? ILE A 99  PRO A 103 
AA1 4 THR A 67  ? PHE A 73  ? THR A 67  PHE A 73  
AA1 5 ILE A 138 ? LYS A 148 ? ILE A 138 LYS A 148 
AA1 6 ALA A 170 ? VAL A 174 ? ALA A 170 VAL A 174 
AA2 1 ILE A 205 ? GLY A 210 ? ILE A 205 GLY A 210 
AA2 2 VAL A 272 ? ILE A 277 ? VAL A 272 ILE A 277 
AA2 3 VAL A 258 ? GLY A 264 ? VAL A 258 GLY A 264 
AA2 4 HIS A 247 ? LEU A 253 ? HIS A 247 LEU A 253 
AA3 1 GLY A 221 ? ARG A 223 ? GLY A 221 ARG A 223 
AA3 2 GLU A 226 ? LEU A 228 ? GLU A 226 LEU A 228 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N VAL A 41  ? N VAL A 41  O TYR A 53  ? O TYR A 53  
AA1 2 3 N HIS A 56  ? N HIS A 56  O ALA A 100 ? O ALA A 100 
AA1 3 4 O VAL A 101 ? O VAL A 101 N ILE A 70  ? N ILE A 70  
AA1 4 5 N LEU A 69  ? N LEU A 69  O TYR A 144 ? O TYR A 144 
AA1 5 6 N GLY A 147 ? N GLY A 147 O VAL A 174 ? O VAL A 174 
AA2 1 2 N ILE A 205 ? N ILE A 205 O THR A 273 ? O THR A 273 
AA2 2 3 O HIS A 274 ? O HIS A 274 N TYR A 261 ? N TYR A 261 
AA2 3 4 O GLY A 264 ? O GLY A 264 N HIS A 247 ? N HIS A 247 
AA3 1 2 N ARG A 223 ? N ARG A 223 O GLU A 226 ? O GLU A 226 
# 
_pdbx_entry_details.entry_id                   9J08 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1 1 NE A ARG 142 ? ? CZ A ARG 142 ? ? NH1 A ARG 142 ? ? 123.76 120.30 3.46  0.50 N 
2 1 NE A ARG 142 ? ? CZ A ARG 142 ? ? NH2 A ARG 142 ? ? 117.26 120.30 -3.04 0.50 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 GLN A 111 ? ? -36.12  134.27  
2 1 SER A 149 ? ? 63.93   -113.34 
3 1 GLU A 226 ? ? -126.32 -167.24 
4 1 ASN A 265 ? ? -136.99 -143.33 
5 1 ASN A 268 ? ? -117.23 56.97   
6 1 THR A 297 ? ? -137.04 -159.61 
# 
_pdbx_validate_peptide_omega.id               1 
_pdbx_validate_peptide_omega.PDB_model_num    1 
_pdbx_validate_peptide_omega.auth_comp_id_1   PRO 
_pdbx_validate_peptide_omega.auth_asym_id_1   A 
_pdbx_validate_peptide_omega.auth_seq_id_1    34 
_pdbx_validate_peptide_omega.PDB_ins_code_1   ? 
_pdbx_validate_peptide_omega.label_alt_id_1   ? 
_pdbx_validate_peptide_omega.auth_comp_id_2   GLY 
_pdbx_validate_peptide_omega.auth_asym_id_2   A 
_pdbx_validate_peptide_omega.auth_seq_id_2    35 
_pdbx_validate_peptide_omega.PDB_ins_code_2   ? 
_pdbx_validate_peptide_omega.label_alt_id_2   ? 
_pdbx_validate_peptide_omega.omega            144.75 
# 
_pdbx_validate_planes.id              1 
_pdbx_validate_planes.PDB_model_num   1 
_pdbx_validate_planes.auth_comp_id    ARG 
_pdbx_validate_planes.auth_asym_id    A 
_pdbx_validate_planes.auth_seq_id     142 
_pdbx_validate_planes.PDB_ins_code    ? 
_pdbx_validate_planes.label_alt_id    ? 
_pdbx_validate_planes.rmsd            0.093 
_pdbx_validate_planes.type            'SIDE CHAIN' 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 1   ? A MET 1   
2  1 Y 1 A LYS 2   ? A LYS 2   
3  1 Y 1 A PHE 3   ? A PHE 3   
4  1 Y 1 A LEU 4   ? A LEU 4   
5  1 Y 1 A SER 5   ? A SER 5   
6  1 Y 1 A VAL 6   ? A VAL 6   
7  1 Y 1 A ILE 7   ? A ILE 7   
8  1 Y 1 A LEU 8   ? A LEU 8   
9  1 Y 1 A LEU 9   ? A LEU 9   
10 1 Y 1 A THR 10  ? A THR 10  
11 1 Y 1 A THR 11  ? A THR 11  
12 1 Y 1 A THR 12  ? A THR 12  
13 1 Y 1 A ALA 13  ? A ALA 13  
14 1 Y 1 A GLY 14  ? A GLY 14  
15 1 Y 1 A LEU 15  ? A LEU 15  
16 1 Y 1 A ALA 16  ? A ALA 16  
17 1 Y 1 A SER 17  ? A SER 17  
18 1 Y 1 A ALA 18  ? A ALA 18  
19 1 Y 1 A ASN 33  ? A ASN 33  
20 1 Y 1 A SER 318 ? A SER 318 
21 1 Y 1 A GLU 319 ? A GLU 319 
22 1 Y 1 A ASP 320 ? A ASP 320 
23 1 Y 1 A ASN 321 ? A ASN 321 
24 1 Y 1 A GLN 322 ? A GLN 322 
25 1 Y 1 A SER 323 ? A SER 323 
26 1 Y 1 A GLU 324 ? A GLU 324 
27 1 Y 1 A ALA 325 ? A ALA 325 
28 1 Y 1 A ARG 326 ? A ARG 326 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ACT C    C N N 1   
ACT O    O N N 2   
ACT OXT  O N N 3   
ACT CH3  C N N 4   
ACT H1   H N N 5   
ACT H2   H N N 6   
ACT H3   H N N 7   
ALA N    N N N 8   
ALA CA   C N S 9   
ALA C    C N N 10  
ALA O    O N N 11  
ALA CB   C N N 12  
ALA OXT  O N N 13  
ALA H    H N N 14  
ALA H2   H N N 15  
ALA HA   H N N 16  
ALA HB1  H N N 17  
ALA HB2  H N N 18  
ALA HB3  H N N 19  
ALA HXT  H N N 20  
ARG N    N N N 21  
ARG CA   C N S 22  
ARG C    C N N 23  
ARG O    O N N 24  
ARG CB   C N N 25  
ARG CG   C N N 26  
ARG CD   C N N 27  
ARG NE   N N N 28  
ARG CZ   C N N 29  
ARG NH1  N N N 30  
ARG NH2  N N N 31  
ARG OXT  O N N 32  
ARG H    H N N 33  
ARG H2   H N N 34  
ARG HA   H N N 35  
ARG HB2  H N N 36  
ARG HB3  H N N 37  
ARG HG2  H N N 38  
ARG HG3  H N N 39  
ARG HD2  H N N 40  
ARG HD3  H N N 41  
ARG HE   H N N 42  
ARG HH11 H N N 43  
ARG HH12 H N N 44  
ARG HH21 H N N 45  
ARG HH22 H N N 46  
ARG HXT  H N N 47  
ASN N    N N N 48  
ASN CA   C N S 49  
ASN C    C N N 50  
ASN O    O N N 51  
ASN CB   C N N 52  
ASN CG   C N N 53  
ASN OD1  O N N 54  
ASN ND2  N N N 55  
ASN OXT  O N N 56  
ASN H    H N N 57  
ASN H2   H N N 58  
ASN HA   H N N 59  
ASN HB2  H N N 60  
ASN HB3  H N N 61  
ASN HD21 H N N 62  
ASN HD22 H N N 63  
ASN HXT  H N N 64  
ASP N    N N N 65  
ASP CA   C N S 66  
ASP C    C N N 67  
ASP O    O N N 68  
ASP CB   C N N 69  
ASP CG   C N N 70  
ASP OD1  O N N 71  
ASP OD2  O N N 72  
ASP OXT  O N N 73  
ASP H    H N N 74  
ASP H2   H N N 75  
ASP HA   H N N 76  
ASP HB2  H N N 77  
ASP HB3  H N N 78  
ASP HD2  H N N 79  
ASP HXT  H N N 80  
CYS N    N N N 81  
CYS CA   C N R 82  
CYS C    C N N 83  
CYS O    O N N 84  
CYS CB   C N N 85  
CYS SG   S N N 86  
CYS OXT  O N N 87  
CYS H    H N N 88  
CYS H2   H N N 89  
CYS HA   H N N 90  
CYS HB2  H N N 91  
CYS HB3  H N N 92  
CYS HG   H N N 93  
CYS HXT  H N N 94  
GLN N    N N N 95  
GLN CA   C N S 96  
GLN C    C N N 97  
GLN O    O N N 98  
GLN CB   C N N 99  
GLN CG   C N N 100 
GLN CD   C N N 101 
GLN OE1  O N N 102 
GLN NE2  N N N 103 
GLN OXT  O N N 104 
GLN H    H N N 105 
GLN H2   H N N 106 
GLN HA   H N N 107 
GLN HB2  H N N 108 
GLN HB3  H N N 109 
GLN HG2  H N N 110 
GLN HG3  H N N 111 
GLN HE21 H N N 112 
GLN HE22 H N N 113 
GLN HXT  H N N 114 
GLU N    N N N 115 
GLU CA   C N S 116 
GLU C    C N N 117 
GLU O    O N N 118 
GLU CB   C N N 119 
GLU CG   C N N 120 
GLU CD   C N N 121 
GLU OE1  O N N 122 
GLU OE2  O N N 123 
GLU OXT  O N N 124 
GLU H    H N N 125 
GLU H2   H N N 126 
GLU HA   H N N 127 
GLU HB2  H N N 128 
GLU HB3  H N N 129 
GLU HG2  H N N 130 
GLU HG3  H N N 131 
GLU HE2  H N N 132 
GLU HXT  H N N 133 
GLY N    N N N 134 
GLY CA   C N N 135 
GLY C    C N N 136 
GLY O    O N N 137 
GLY OXT  O N N 138 
GLY H    H N N 139 
GLY H2   H N N 140 
GLY HA2  H N N 141 
GLY HA3  H N N 142 
GLY HXT  H N N 143 
HIS N    N N N 144 
HIS CA   C N S 145 
HIS C    C N N 146 
HIS O    O N N 147 
HIS CB   C N N 148 
HIS CG   C Y N 149 
HIS ND1  N Y N 150 
HIS CD2  C Y N 151 
HIS CE1  C Y N 152 
HIS NE2  N Y N 153 
HIS OXT  O N N 154 
HIS H    H N N 155 
HIS H2   H N N 156 
HIS HA   H N N 157 
HIS HB2  H N N 158 
HIS HB3  H N N 159 
HIS HD1  H N N 160 
HIS HD2  H N N 161 
HIS HE1  H N N 162 
HIS HE2  H N N 163 
HIS HXT  H N N 164 
HOH O    O N N 165 
HOH H1   H N N 166 
HOH H2   H N N 167 
ILE N    N N N 168 
ILE CA   C N S 169 
ILE C    C N N 170 
ILE O    O N N 171 
ILE CB   C N S 172 
ILE CG1  C N N 173 
ILE CG2  C N N 174 
ILE CD1  C N N 175 
ILE OXT  O N N 176 
ILE H    H N N 177 
ILE H2   H N N 178 
ILE HA   H N N 179 
ILE HB   H N N 180 
ILE HG12 H N N 181 
ILE HG13 H N N 182 
ILE HG21 H N N 183 
ILE HG22 H N N 184 
ILE HG23 H N N 185 
ILE HD11 H N N 186 
ILE HD12 H N N 187 
ILE HD13 H N N 188 
ILE HXT  H N N 189 
LEU N    N N N 190 
LEU CA   C N S 191 
LEU C    C N N 192 
LEU O    O N N 193 
LEU CB   C N N 194 
LEU CG   C N N 195 
LEU CD1  C N N 196 
LEU CD2  C N N 197 
LEU OXT  O N N 198 
LEU H    H N N 199 
LEU H2   H N N 200 
LEU HA   H N N 201 
LEU HB2  H N N 202 
LEU HB3  H N N 203 
LEU HG   H N N 204 
LEU HD11 H N N 205 
LEU HD12 H N N 206 
LEU HD13 H N N 207 
LEU HD21 H N N 208 
LEU HD22 H N N 209 
LEU HD23 H N N 210 
LEU HXT  H N N 211 
LYS N    N N N 212 
LYS CA   C N S 213 
LYS C    C N N 214 
LYS O    O N N 215 
LYS CB   C N N 216 
LYS CG   C N N 217 
LYS CD   C N N 218 
LYS CE   C N N 219 
LYS NZ   N N N 220 
LYS OXT  O N N 221 
LYS H    H N N 222 
LYS H2   H N N 223 
LYS HA   H N N 224 
LYS HB2  H N N 225 
LYS HB3  H N N 226 
LYS HG2  H N N 227 
LYS HG3  H N N 228 
LYS HD2  H N N 229 
LYS HD3  H N N 230 
LYS HE2  H N N 231 
LYS HE3  H N N 232 
LYS HZ1  H N N 233 
LYS HZ2  H N N 234 
LYS HZ3  H N N 235 
LYS HXT  H N N 236 
MET N    N N N 237 
MET CA   C N S 238 
MET C    C N N 239 
MET O    O N N 240 
MET CB   C N N 241 
MET CG   C N N 242 
MET SD   S N N 243 
MET CE   C N N 244 
MET OXT  O N N 245 
MET H    H N N 246 
MET H2   H N N 247 
MET HA   H N N 248 
MET HB2  H N N 249 
MET HB3  H N N 250 
MET HG2  H N N 251 
MET HG3  H N N 252 
MET HE1  H N N 253 
MET HE2  H N N 254 
MET HE3  H N N 255 
MET HXT  H N N 256 
NAG C1   C N R 257 
NAG C2   C N R 258 
NAG C3   C N R 259 
NAG C4   C N S 260 
NAG C5   C N R 261 
NAG C6   C N N 262 
NAG C7   C N N 263 
NAG C8   C N N 264 
NAG N2   N N N 265 
NAG O1   O N N 266 
NAG O3   O N N 267 
NAG O4   O N N 268 
NAG O5   O N N 269 
NAG O6   O N N 270 
NAG O7   O N N 271 
NAG H1   H N N 272 
NAG H2   H N N 273 
NAG H3   H N N 274 
NAG H4   H N N 275 
NAG H5   H N N 276 
NAG H61  H N N 277 
NAG H62  H N N 278 
NAG H81  H N N 279 
NAG H82  H N N 280 
NAG H83  H N N 281 
NAG HN2  H N N 282 
NAG HO1  H N N 283 
NAG HO3  H N N 284 
NAG HO4  H N N 285 
NAG HO6  H N N 286 
PHE N    N N N 287 
PHE CA   C N S 288 
PHE C    C N N 289 
PHE O    O N N 290 
PHE CB   C N N 291 
PHE CG   C Y N 292 
PHE CD1  C Y N 293 
PHE CD2  C Y N 294 
PHE CE1  C Y N 295 
PHE CE2  C Y N 296 
PHE CZ   C Y N 297 
PHE OXT  O N N 298 
PHE H    H N N 299 
PHE H2   H N N 300 
PHE HA   H N N 301 
PHE HB2  H N N 302 
PHE HB3  H N N 303 
PHE HD1  H N N 304 
PHE HD2  H N N 305 
PHE HE1  H N N 306 
PHE HE2  H N N 307 
PHE HZ   H N N 308 
PHE HXT  H N N 309 
PRO N    N N N 310 
PRO CA   C N S 311 
PRO C    C N N 312 
PRO O    O N N 313 
PRO CB   C N N 314 
PRO CG   C N N 315 
PRO CD   C N N 316 
PRO OXT  O N N 317 
PRO H    H N N 318 
PRO HA   H N N 319 
PRO HB2  H N N 320 
PRO HB3  H N N 321 
PRO HG2  H N N 322 
PRO HG3  H N N 323 
PRO HD2  H N N 324 
PRO HD3  H N N 325 
PRO HXT  H N N 326 
SER N    N N N 327 
SER CA   C N S 328 
SER C    C N N 329 
SER O    O N N 330 
SER CB   C N N 331 
SER OG   O N N 332 
SER OXT  O N N 333 
SER H    H N N 334 
SER H2   H N N 335 
SER HA   H N N 336 
SER HB2  H N N 337 
SER HB3  H N N 338 
SER HG   H N N 339 
SER HXT  H N N 340 
SIN C1   C N N 341 
SIN O1   O N N 342 
SIN O2   O N N 343 
SIN C2   C N N 344 
SIN C3   C N N 345 
SIN C4   C N N 346 
SIN O3   O N N 347 
SIN O4   O N N 348 
SIN HO2  H N N 349 
SIN H21  H N N 350 
SIN H22  H N N 351 
SIN H31  H N N 352 
SIN H32  H N N 353 
SIN HO4  H N N 354 
THR N    N N N 355 
THR CA   C N S 356 
THR C    C N N 357 
THR O    O N N 358 
THR CB   C N R 359 
THR OG1  O N N 360 
THR CG2  C N N 361 
THR OXT  O N N 362 
THR H    H N N 363 
THR H2   H N N 364 
THR HA   H N N 365 
THR HB   H N N 366 
THR HG1  H N N 367 
THR HG21 H N N 368 
THR HG22 H N N 369 
THR HG23 H N N 370 
THR HXT  H N N 371 
TRP N    N N N 372 
TRP CA   C N S 373 
TRP C    C N N 374 
TRP O    O N N 375 
TRP CB   C N N 376 
TRP CG   C Y N 377 
TRP CD1  C Y N 378 
TRP CD2  C Y N 379 
TRP NE1  N Y N 380 
TRP CE2  C Y N 381 
TRP CE3  C Y N 382 
TRP CZ2  C Y N 383 
TRP CZ3  C Y N 384 
TRP CH2  C Y N 385 
TRP OXT  O N N 386 
TRP H    H N N 387 
TRP H2   H N N 388 
TRP HA   H N N 389 
TRP HB2  H N N 390 
TRP HB3  H N N 391 
TRP HD1  H N N 392 
TRP HE1  H N N 393 
TRP HE3  H N N 394 
TRP HZ2  H N N 395 
TRP HZ3  H N N 396 
TRP HH2  H N N 397 
TRP HXT  H N N 398 
TYR N    N N N 399 
TYR CA   C N S 400 
TYR C    C N N 401 
TYR O    O N N 402 
TYR CB   C N N 403 
TYR CG   C Y N 404 
TYR CD1  C Y N 405 
TYR CD2  C Y N 406 
TYR CE1  C Y N 407 
TYR CE2  C Y N 408 
TYR CZ   C Y N 409 
TYR OH   O N N 410 
TYR OXT  O N N 411 
TYR H    H N N 412 
TYR H2   H N N 413 
TYR HA   H N N 414 
TYR HB2  H N N 415 
TYR HB3  H N N 416 
TYR HD1  H N N 417 
TYR HD2  H N N 418 
TYR HE1  H N N 419 
TYR HE2  H N N 420 
TYR HH   H N N 421 
TYR HXT  H N N 422 
VAL N    N N N 423 
VAL CA   C N S 424 
VAL C    C N N 425 
VAL O    O N N 426 
VAL CB   C N N 427 
VAL CG1  C N N 428 
VAL CG2  C N N 429 
VAL OXT  O N N 430 
VAL H    H N N 431 
VAL H2   H N N 432 
VAL HA   H N N 433 
VAL HB   H N N 434 
VAL HG11 H N N 435 
VAL HG12 H N N 436 
VAL HG13 H N N 437 
VAL HG21 H N N 438 
VAL HG22 H N N 439 
VAL HG23 H N N 440 
VAL HXT  H N N 441 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ACT C   O    doub N N 1   
ACT C   OXT  sing N N 2   
ACT C   CH3  sing N N 3   
ACT CH3 H1   sing N N 4   
ACT CH3 H2   sing N N 5   
ACT CH3 H3   sing N N 6   
ALA N   CA   sing N N 7   
ALA N   H    sing N N 8   
ALA N   H2   sing N N 9   
ALA CA  C    sing N N 10  
ALA CA  CB   sing N N 11  
ALA CA  HA   sing N N 12  
ALA C   O    doub N N 13  
ALA C   OXT  sing N N 14  
ALA CB  HB1  sing N N 15  
ALA CB  HB2  sing N N 16  
ALA CB  HB3  sing N N 17  
ALA OXT HXT  sing N N 18  
ARG N   CA   sing N N 19  
ARG N   H    sing N N 20  
ARG N   H2   sing N N 21  
ARG CA  C    sing N N 22  
ARG CA  CB   sing N N 23  
ARG CA  HA   sing N N 24  
ARG C   O    doub N N 25  
ARG C   OXT  sing N N 26  
ARG CB  CG   sing N N 27  
ARG CB  HB2  sing N N 28  
ARG CB  HB3  sing N N 29  
ARG CG  CD   sing N N 30  
ARG CG  HG2  sing N N 31  
ARG CG  HG3  sing N N 32  
ARG CD  NE   sing N N 33  
ARG CD  HD2  sing N N 34  
ARG CD  HD3  sing N N 35  
ARG NE  CZ   sing N N 36  
ARG NE  HE   sing N N 37  
ARG CZ  NH1  sing N N 38  
ARG CZ  NH2  doub N N 39  
ARG NH1 HH11 sing N N 40  
ARG NH1 HH12 sing N N 41  
ARG NH2 HH21 sing N N 42  
ARG NH2 HH22 sing N N 43  
ARG OXT HXT  sing N N 44  
ASN N   CA   sing N N 45  
ASN N   H    sing N N 46  
ASN N   H2   sing N N 47  
ASN CA  C    sing N N 48  
ASN CA  CB   sing N N 49  
ASN CA  HA   sing N N 50  
ASN C   O    doub N N 51  
ASN C   OXT  sing N N 52  
ASN CB  CG   sing N N 53  
ASN CB  HB2  sing N N 54  
ASN CB  HB3  sing N N 55  
ASN CG  OD1  doub N N 56  
ASN CG  ND2  sing N N 57  
ASN ND2 HD21 sing N N 58  
ASN ND2 HD22 sing N N 59  
ASN OXT HXT  sing N N 60  
ASP N   CA   sing N N 61  
ASP N   H    sing N N 62  
ASP N   H2   sing N N 63  
ASP CA  C    sing N N 64  
ASP CA  CB   sing N N 65  
ASP CA  HA   sing N N 66  
ASP C   O    doub N N 67  
ASP C   OXT  sing N N 68  
ASP CB  CG   sing N N 69  
ASP CB  HB2  sing N N 70  
ASP CB  HB3  sing N N 71  
ASP CG  OD1  doub N N 72  
ASP CG  OD2  sing N N 73  
ASP OD2 HD2  sing N N 74  
ASP OXT HXT  sing N N 75  
CYS N   CA   sing N N 76  
CYS N   H    sing N N 77  
CYS N   H2   sing N N 78  
CYS CA  C    sing N N 79  
CYS CA  CB   sing N N 80  
CYS CA  HA   sing N N 81  
CYS C   O    doub N N 82  
CYS C   OXT  sing N N 83  
CYS CB  SG   sing N N 84  
CYS CB  HB2  sing N N 85  
CYS CB  HB3  sing N N 86  
CYS SG  HG   sing N N 87  
CYS OXT HXT  sing N N 88  
GLN N   CA   sing N N 89  
GLN N   H    sing N N 90  
GLN N   H2   sing N N 91  
GLN CA  C    sing N N 92  
GLN CA  CB   sing N N 93  
GLN CA  HA   sing N N 94  
GLN C   O    doub N N 95  
GLN C   OXT  sing N N 96  
GLN CB  CG   sing N N 97  
GLN CB  HB2  sing N N 98  
GLN CB  HB3  sing N N 99  
GLN CG  CD   sing N N 100 
GLN CG  HG2  sing N N 101 
GLN CG  HG3  sing N N 102 
GLN CD  OE1  doub N N 103 
GLN CD  NE2  sing N N 104 
GLN NE2 HE21 sing N N 105 
GLN NE2 HE22 sing N N 106 
GLN OXT HXT  sing N N 107 
GLU N   CA   sing N N 108 
GLU N   H    sing N N 109 
GLU N   H2   sing N N 110 
GLU CA  C    sing N N 111 
GLU CA  CB   sing N N 112 
GLU CA  HA   sing N N 113 
GLU C   O    doub N N 114 
GLU C   OXT  sing N N 115 
GLU CB  CG   sing N N 116 
GLU CB  HB2  sing N N 117 
GLU CB  HB3  sing N N 118 
GLU CG  CD   sing N N 119 
GLU CG  HG2  sing N N 120 
GLU CG  HG3  sing N N 121 
GLU CD  OE1  doub N N 122 
GLU CD  OE2  sing N N 123 
GLU OE2 HE2  sing N N 124 
GLU OXT HXT  sing N N 125 
GLY N   CA   sing N N 126 
GLY N   H    sing N N 127 
GLY N   H2   sing N N 128 
GLY CA  C    sing N N 129 
GLY CA  HA2  sing N N 130 
GLY CA  HA3  sing N N 131 
GLY C   O    doub N N 132 
GLY C   OXT  sing N N 133 
GLY OXT HXT  sing N N 134 
HIS N   CA   sing N N 135 
HIS N   H    sing N N 136 
HIS N   H2   sing N N 137 
HIS CA  C    sing N N 138 
HIS CA  CB   sing N N 139 
HIS CA  HA   sing N N 140 
HIS C   O    doub N N 141 
HIS C   OXT  sing N N 142 
HIS CB  CG   sing N N 143 
HIS CB  HB2  sing N N 144 
HIS CB  HB3  sing N N 145 
HIS CG  ND1  sing Y N 146 
HIS CG  CD2  doub Y N 147 
HIS ND1 CE1  doub Y N 148 
HIS ND1 HD1  sing N N 149 
HIS CD2 NE2  sing Y N 150 
HIS CD2 HD2  sing N N 151 
HIS CE1 NE2  sing Y N 152 
HIS CE1 HE1  sing N N 153 
HIS NE2 HE2  sing N N 154 
HIS OXT HXT  sing N N 155 
HOH O   H1   sing N N 156 
HOH O   H2   sing N N 157 
ILE N   CA   sing N N 158 
ILE N   H    sing N N 159 
ILE N   H2   sing N N 160 
ILE CA  C    sing N N 161 
ILE CA  CB   sing N N 162 
ILE CA  HA   sing N N 163 
ILE C   O    doub N N 164 
ILE C   OXT  sing N N 165 
ILE CB  CG1  sing N N 166 
ILE CB  CG2  sing N N 167 
ILE CB  HB   sing N N 168 
ILE CG1 CD1  sing N N 169 
ILE CG1 HG12 sing N N 170 
ILE CG1 HG13 sing N N 171 
ILE CG2 HG21 sing N N 172 
ILE CG2 HG22 sing N N 173 
ILE CG2 HG23 sing N N 174 
ILE CD1 HD11 sing N N 175 
ILE CD1 HD12 sing N N 176 
ILE CD1 HD13 sing N N 177 
ILE OXT HXT  sing N N 178 
LEU N   CA   sing N N 179 
LEU N   H    sing N N 180 
LEU N   H2   sing N N 181 
LEU CA  C    sing N N 182 
LEU CA  CB   sing N N 183 
LEU CA  HA   sing N N 184 
LEU C   O    doub N N 185 
LEU C   OXT  sing N N 186 
LEU CB  CG   sing N N 187 
LEU CB  HB2  sing N N 188 
LEU CB  HB3  sing N N 189 
LEU CG  CD1  sing N N 190 
LEU CG  CD2  sing N N 191 
LEU CG  HG   sing N N 192 
LEU CD1 HD11 sing N N 193 
LEU CD1 HD12 sing N N 194 
LEU CD1 HD13 sing N N 195 
LEU CD2 HD21 sing N N 196 
LEU CD2 HD22 sing N N 197 
LEU CD2 HD23 sing N N 198 
LEU OXT HXT  sing N N 199 
LYS N   CA   sing N N 200 
LYS N   H    sing N N 201 
LYS N   H2   sing N N 202 
LYS CA  C    sing N N 203 
LYS CA  CB   sing N N 204 
LYS CA  HA   sing N N 205 
LYS C   O    doub N N 206 
LYS C   OXT  sing N N 207 
LYS CB  CG   sing N N 208 
LYS CB  HB2  sing N N 209 
LYS CB  HB3  sing N N 210 
LYS CG  CD   sing N N 211 
LYS CG  HG2  sing N N 212 
LYS CG  HG3  sing N N 213 
LYS CD  CE   sing N N 214 
LYS CD  HD2  sing N N 215 
LYS CD  HD3  sing N N 216 
LYS CE  NZ   sing N N 217 
LYS CE  HE2  sing N N 218 
LYS CE  HE3  sing N N 219 
LYS NZ  HZ1  sing N N 220 
LYS NZ  HZ2  sing N N 221 
LYS NZ  HZ3  sing N N 222 
LYS OXT HXT  sing N N 223 
MET N   CA   sing N N 224 
MET N   H    sing N N 225 
MET N   H2   sing N N 226 
MET CA  C    sing N N 227 
MET CA  CB   sing N N 228 
MET CA  HA   sing N N 229 
MET C   O    doub N N 230 
MET C   OXT  sing N N 231 
MET CB  CG   sing N N 232 
MET CB  HB2  sing N N 233 
MET CB  HB3  sing N N 234 
MET CG  SD   sing N N 235 
MET CG  HG2  sing N N 236 
MET CG  HG3  sing N N 237 
MET SD  CE   sing N N 238 
MET CE  HE1  sing N N 239 
MET CE  HE2  sing N N 240 
MET CE  HE3  sing N N 241 
MET OXT HXT  sing N N 242 
NAG C1  C2   sing N N 243 
NAG C1  O1   sing N N 244 
NAG C1  O5   sing N N 245 
NAG C1  H1   sing N N 246 
NAG C2  C3   sing N N 247 
NAG C2  N2   sing N N 248 
NAG C2  H2   sing N N 249 
NAG C3  C4   sing N N 250 
NAG C3  O3   sing N N 251 
NAG C3  H3   sing N N 252 
NAG C4  C5   sing N N 253 
NAG C4  O4   sing N N 254 
NAG C4  H4   sing N N 255 
NAG C5  C6   sing N N 256 
NAG C5  O5   sing N N 257 
NAG C5  H5   sing N N 258 
NAG C6  O6   sing N N 259 
NAG C6  H61  sing N N 260 
NAG C6  H62  sing N N 261 
NAG C7  C8   sing N N 262 
NAG C7  N2   sing N N 263 
NAG C7  O7   doub N N 264 
NAG C8  H81  sing N N 265 
NAG C8  H82  sing N N 266 
NAG C8  H83  sing N N 267 
NAG N2  HN2  sing N N 268 
NAG O1  HO1  sing N N 269 
NAG O3  HO3  sing N N 270 
NAG O4  HO4  sing N N 271 
NAG O6  HO6  sing N N 272 
PHE N   CA   sing N N 273 
PHE N   H    sing N N 274 
PHE N   H2   sing N N 275 
PHE CA  C    sing N N 276 
PHE CA  CB   sing N N 277 
PHE CA  HA   sing N N 278 
PHE C   O    doub N N 279 
PHE C   OXT  sing N N 280 
PHE CB  CG   sing N N 281 
PHE CB  HB2  sing N N 282 
PHE CB  HB3  sing N N 283 
PHE CG  CD1  doub Y N 284 
PHE CG  CD2  sing Y N 285 
PHE CD1 CE1  sing Y N 286 
PHE CD1 HD1  sing N N 287 
PHE CD2 CE2  doub Y N 288 
PHE CD2 HD2  sing N N 289 
PHE CE1 CZ   doub Y N 290 
PHE CE1 HE1  sing N N 291 
PHE CE2 CZ   sing Y N 292 
PHE CE2 HE2  sing N N 293 
PHE CZ  HZ   sing N N 294 
PHE OXT HXT  sing N N 295 
PRO N   CA   sing N N 296 
PRO N   CD   sing N N 297 
PRO N   H    sing N N 298 
PRO CA  C    sing N N 299 
PRO CA  CB   sing N N 300 
PRO CA  HA   sing N N 301 
PRO C   O    doub N N 302 
PRO C   OXT  sing N N 303 
PRO CB  CG   sing N N 304 
PRO CB  HB2  sing N N 305 
PRO CB  HB3  sing N N 306 
PRO CG  CD   sing N N 307 
PRO CG  HG2  sing N N 308 
PRO CG  HG3  sing N N 309 
PRO CD  HD2  sing N N 310 
PRO CD  HD3  sing N N 311 
PRO OXT HXT  sing N N 312 
SER N   CA   sing N N 313 
SER N   H    sing N N 314 
SER N   H2   sing N N 315 
SER CA  C    sing N N 316 
SER CA  CB   sing N N 317 
SER CA  HA   sing N N 318 
SER C   O    doub N N 319 
SER C   OXT  sing N N 320 
SER CB  OG   sing N N 321 
SER CB  HB2  sing N N 322 
SER CB  HB3  sing N N 323 
SER OG  HG   sing N N 324 
SER OXT HXT  sing N N 325 
SIN C1  O1   doub N N 326 
SIN C1  O2   sing N N 327 
SIN C1  C2   sing N N 328 
SIN O2  HO2  sing N N 329 
SIN C2  C3   sing N N 330 
SIN C2  H21  sing N N 331 
SIN C2  H22  sing N N 332 
SIN C3  C4   sing N N 333 
SIN C3  H31  sing N N 334 
SIN C3  H32  sing N N 335 
SIN C4  O3   doub N N 336 
SIN C4  O4   sing N N 337 
SIN O4  HO4  sing N N 338 
THR N   CA   sing N N 339 
THR N   H    sing N N 340 
THR N   H2   sing N N 341 
THR CA  C    sing N N 342 
THR CA  CB   sing N N 343 
THR CA  HA   sing N N 344 
THR C   O    doub N N 345 
THR C   OXT  sing N N 346 
THR CB  OG1  sing N N 347 
THR CB  CG2  sing N N 348 
THR CB  HB   sing N N 349 
THR OG1 HG1  sing N N 350 
THR CG2 HG21 sing N N 351 
THR CG2 HG22 sing N N 352 
THR CG2 HG23 sing N N 353 
THR OXT HXT  sing N N 354 
TRP N   CA   sing N N 355 
TRP N   H    sing N N 356 
TRP N   H2   sing N N 357 
TRP CA  C    sing N N 358 
TRP CA  CB   sing N N 359 
TRP CA  HA   sing N N 360 
TRP C   O    doub N N 361 
TRP C   OXT  sing N N 362 
TRP CB  CG   sing N N 363 
TRP CB  HB2  sing N N 364 
TRP CB  HB3  sing N N 365 
TRP CG  CD1  doub Y N 366 
TRP CG  CD2  sing Y N 367 
TRP CD1 NE1  sing Y N 368 
TRP CD1 HD1  sing N N 369 
TRP CD2 CE2  doub Y N 370 
TRP CD2 CE3  sing Y N 371 
TRP NE1 CE2  sing Y N 372 
TRP NE1 HE1  sing N N 373 
TRP CE2 CZ2  sing Y N 374 
TRP CE3 CZ3  doub Y N 375 
TRP CE3 HE3  sing N N 376 
TRP CZ2 CH2  doub Y N 377 
TRP CZ2 HZ2  sing N N 378 
TRP CZ3 CH2  sing Y N 379 
TRP CZ3 HZ3  sing N N 380 
TRP CH2 HH2  sing N N 381 
TRP OXT HXT  sing N N 382 
TYR N   CA   sing N N 383 
TYR N   H    sing N N 384 
TYR N   H2   sing N N 385 
TYR CA  C    sing N N 386 
TYR CA  CB   sing N N 387 
TYR CA  HA   sing N N 388 
TYR C   O    doub N N 389 
TYR C   OXT  sing N N 390 
TYR CB  CG   sing N N 391 
TYR CB  HB2  sing N N 392 
TYR CB  HB3  sing N N 393 
TYR CG  CD1  doub Y N 394 
TYR CG  CD2  sing Y N 395 
TYR CD1 CE1  sing Y N 396 
TYR CD1 HD1  sing N N 397 
TYR CD2 CE2  doub Y N 398 
TYR CD2 HD2  sing N N 399 
TYR CE1 CZ   doub Y N 400 
TYR CE1 HE1  sing N N 401 
TYR CE2 CZ   sing Y N 402 
TYR CE2 HE2  sing N N 403 
TYR CZ  OH   sing N N 404 
TYR OH  HH   sing N N 405 
TYR OXT HXT  sing N N 406 
VAL N   CA   sing N N 407 
VAL N   H    sing N N 408 
VAL N   H2   sing N N 409 
VAL CA  C    sing N N 410 
VAL CA  CB   sing N N 411 
VAL CA  HA   sing N N 412 
VAL C   O    doub N N 413 
VAL C   OXT  sing N N 414 
VAL CB  CG1  sing N N 415 
VAL CB  CG2  sing N N 416 
VAL CB  HB   sing N N 417 
VAL CG1 HG11 sing N N 418 
VAL CG1 HG12 sing N N 419 
VAL CG1 HG13 sing N N 420 
VAL CG2 HG21 sing N N 421 
VAL CG2 HG22 sing N N 422 
VAL CG2 HG23 sing N N 423 
VAL OXT HXT  sing N N 424 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   3WYD 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9J08 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.017536 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   -0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.015623 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   -0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.012001 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . ALA A 1 19  ? 15.224  -19.983 -6.583  1.00 45.99 ? 19  ALA A N   1 
ATOM   2    C CA  . ALA A 1 19  ? 16.047  -21.054 -7.195  1.00 44.34 ? 19  ALA A CA  1 
ATOM   3    C C   . ALA A 1 19  ? 17.520  -20.731 -6.963  1.00 38.80 ? 19  ALA A C   1 
ATOM   4    O O   . ALA A 1 19  ? 17.984  -19.733 -7.550  1.00 25.18 ? 19  ALA A O   1 
ATOM   5    C CB  . ALA A 1 19  ? 15.747  -21.158 -8.681  1.00 48.15 ? 19  ALA A CB  1 
ATOM   6    N N   . GLY A 1 20  ? 18.191  -21.572 -6.123  1.00 30.34 ? 20  GLY A N   1 
ATOM   7    C CA  . GLY A 1 20  ? 19.609  -21.445 -5.791  1.00 24.30 ? 20  GLY A CA  1 
ATOM   8    C C   . GLY A 1 20  ? 20.509  -21.782 -6.981  1.00 20.02 ? 20  GLY A C   1 
ATOM   9    O O   . GLY A 1 20  ? 20.322  -22.795 -7.630  1.00 19.58 ? 20  GLY A O   1 
ATOM   10   N N   . SER A 1 21  ? 21.537  -20.968 -7.226  1.00 17.67 ? 21  SER A N   1 
ATOM   11   C CA  . SER A 1 21  ? 22.351  -21.053 -8.427  1.00 15.37 ? 21  SER A CA  1 
ATOM   12   C C   . SER A 1 21  ? 23.433  -22.132 -8.281  1.00 15.55 ? 21  SER A C   1 
ATOM   13   O O   . SER A 1 21  ? 23.624  -22.745 -7.214  1.00 13.94 ? 21  SER A O   1 
ATOM   14   C CB  . SER A 1 21  ? 22.956  -19.696 -8.723  1.00 14.32 ? 21  SER A CB  1 
ATOM   15   O OG  . SER A 1 21  ? 23.852  -19.313 -7.682  1.00 13.31 ? 21  SER A OG  1 
ATOM   16   N N   . ALA A 1 22  ? 24.169  -22.347 -9.379  1.00 14.89 ? 22  ALA A N   1 
ATOM   17   C CA  . ALA A 1 22  ? 25.239  -23.333 -9.423  1.00 15.69 ? 22  ALA A CA  1 
ATOM   18   C C   . ALA A 1 22  ? 26.305  -23.092 -8.347  1.00 16.15 ? 22  ALA A C   1 
ATOM   19   O O   . ALA A 1 22  ? 26.857  -24.054 -7.819  1.00 16.47 ? 22  ALA A O   1 
ATOM   20   C CB  . ALA A 1 22  ? 25.847  -23.345 -10.812 1.00 17.65 ? 22  ALA A CB  1 
ATOM   21   N N   . GLY A 1 23  ? 26.544  -21.828 -7.949  1.00 13.43 ? 23  GLY A N   1 
ATOM   22   C CA  . GLY A 1 23  ? 27.598  -21.496 -7.012  1.00 14.31 ? 23  GLY A CA  1 
ATOM   23   C C   . GLY A 1 23  ? 27.286  -21.915 -5.579  1.00 14.33 ? 23  GLY A C   1 
ATOM   24   O O   . GLY A 1 23  ? 28.126  -21.745 -4.705  1.00 17.62 ? 23  GLY A O   1 
ATOM   25   N N   . CYS A 1 24  ? 26.065  -22.375 -5.320  1.00 13.53 ? 24  CYS A N   1 
ATOM   26   C CA  . CYS A 1 24  ? 25.689  -22.785 -3.977  1.00 14.65 ? 24  CYS A CA  1 
ATOM   27   C C   . CYS A 1 24  ? 26.596  -23.929 -3.542  1.00 15.78 ? 24  CYS A C   1 
ATOM   28   O O   . CYS A 1 24  ? 26.819  -24.868 -4.300  1.00 13.68 ? 24  CYS A O   1 
ATOM   29   C CB  . CYS A 1 24  ? 24.232  -23.219 -3.877  1.00 16.02 ? 24  CYS A CB  1 
ATOM   30   S SG  . CYS A 1 24  ? 23.042  -21.867 -4.133  1.00 17.12 ? 24  CYS A SG  1 
ATOM   31   N N   . GLY A 1 25  ? 27.188  -23.800 -2.359  1.00 15.75 ? 25  GLY A N   1 
ATOM   32   C CA  . GLY A 1 25  ? 28.119  -24.809 -1.872  1.00 16.27 ? 25  GLY A CA  1 
ATOM   33   C C   . GLY A 1 25  ? 29.560  -24.385 -2.082  1.00 16.45 ? 25  GLY A C   1 
ATOM   34   O O   . GLY A 1 25  ? 30.454  -24.940 -1.455  1.00 16.07 ? 25  GLY A O   1 
ATOM   35   N N   . GLN A 1 26  ? 29.781  -23.375 -2.930  1.00 15.50 ? 26  GLN A N   1 
ATOM   36   C CA  . GLN A 1 26  ? 31.138  -22.925 -3.197  1.00 19.08 ? 26  GLN A CA  1 
ATOM   37   C C   . GLN A 1 26  ? 31.605  -21.942 -2.129  1.00 18.11 ? 26  GLN A C   1 
ATOM   38   O O   . GLN A 1 26  ? 30.862  -21.074 -1.712  1.00 18.60 ? 26  GLN A O   1 
ATOM   39   C CB  . GLN A 1 26  ? 31.232  -22.199 -4.536  1.00 21.83 ? 26  GLN A CB  1 
ATOM   40   C CG  . GLN A 1 26  ? 30.781  -23.047 -5.701  1.00 23.93 ? 26  GLN A CG  1 
ATOM   41   C CD  . GLN A 1 26  ? 31.861  -24.046 -6.010  1.00 29.99 ? 26  GLN A CD  1 
ATOM   42   O OE1 . GLN A 1 26  ? 33.017  -23.676 -6.226  1.00 32.46 ? 26  GLN A OE1 1 
ATOM   43   N NE2 . GLN A 1 26  ? 31.499  -25.317 -5.979  1.00 33.75 ? 26  GLN A NE2 1 
ATOM   44   N N   . PRO A 1 27  ? 32.892  -22.000 -1.723  1.00 17.69 ? 27  PRO A N   1 
ATOM   45   C CA  . PRO A 1 27  ? 33.417  -21.037 -0.771  1.00 18.08 ? 27  PRO A CA  1 
ATOM   46   C C   . PRO A 1 27  ? 33.578  -19.654 -1.409  1.00 19.82 ? 27  PRO A C   1 
ATOM   47   O O   . PRO A 1 27  ? 33.825  -19.548 -2.608  1.00 16.92 ? 27  PRO A O   1 
ATOM   48   C CB  . PRO A 1 27  ? 34.768  -21.644 -0.377  1.00 17.85 ? 27  PRO A CB  1 
ATOM   49   C CG  . PRO A 1 27  ? 35.186  -22.503 -1.555  1.00 17.42 ? 27  PRO A CG  1 
ATOM   50   C CD  . PRO A 1 27  ? 33.896  -22.954 -2.211  1.00 17.53 ? 27  PRO A CD  1 
ATOM   51   N N   . LEU A 1 28  ? 33.461  -18.612 -0.573  1.00 20.57 ? 28  LEU A N   1 
ATOM   52   C CA  . LEU A 1 28  ? 33.724  -17.234 -0.961  1.00 23.95 ? 28  LEU A CA  1 
ATOM   53   C C   . LEU A 1 28  ? 35.105  -17.148 -1.610  1.00 28.52 ? 28  LEU A C   1 
ATOM   54   O O   . LEU A 1 28  ? 36.048  -17.788 -1.145  1.00 24.16 ? 28  LEU A O   1 
ATOM   55   C CB  . LEU A 1 28  ? 33.730  -16.334 0.287   1.00 28.70 ? 28  LEU A CB  1 
ATOM   56   C CG  . LEU A 1 28  ? 32.396  -15.765 0.765   1.00 30.17 ? 28  LEU A CG  1 
ATOM   57   C CD1 . LEU A 1 28  ? 31.406  -16.877 1.000   1.00 33.81 ? 28  LEU A CD1 1 
ATOM   58   C CD2 . LEU A 1 28  ? 32.572  -14.971 2.039   1.00 28.14 ? 28  LEU A CD2 1 
ATOM   59   N N   . PRO A 1 29  ? 35.282  -16.308 -2.656  1.00 29.73 ? 29  PRO A N   1 
ATOM   60   C CA  . PRO A 1 29  ? 36.618  -15.937 -3.129  1.00 30.35 ? 29  PRO A CA  1 
ATOM   61   C C   . PRO A 1 29  ? 37.515  -15.527 -1.962  1.00 31.84 ? 29  PRO A C   1 
ATOM   62   O O   . PRO A 1 29  ? 37.087  -14.755 -1.105  1.00 33.10 ? 29  PRO A O   1 
ATOM   63   C CB  . PRO A 1 29  ? 36.332  -14.755 -4.059  1.00 32.11 ? 29  PRO A CB  1 
ATOM   64   C CG  . PRO A 1 29  ? 34.967  -15.068 -4.598  1.00 31.42 ? 29  PRO A CG  1 
ATOM   65   C CD  . PRO A 1 29  ? 34.209  -15.661 -3.422  1.00 30.50 ? 29  PRO A CD  1 
ATOM   66   N N   . PRO A 1 30  ? 38.781  -16.018 -1.906  1.00 38.53 ? 30  PRO A N   1 
ATOM   67   C CA  . PRO A 1 30  ? 39.557  -16.071 -0.662  1.00 42.57 ? 30  PRO A CA  1 
ATOM   68   C C   . PRO A 1 30  ? 40.060  -14.749 -0.088  1.00 44.15 ? 30  PRO A C   1 
ATOM   69   O O   . PRO A 1 30  ? 40.604  -14.730 1.011   1.00 51.12 ? 30  PRO A O   1 
ATOM   70   C CB  . PRO A 1 30  ? 40.779  -16.938 -1.018  1.00 45.99 ? 30  PRO A CB  1 
ATOM   71   C CG  . PRO A 1 30  ? 40.454  -17.553 -2.370  1.00 44.41 ? 30  PRO A CG  1 
ATOM   72   C CD  . PRO A 1 30  ? 39.548  -16.549 -3.044  1.00 40.59 ? 30  PRO A CD  1 
ATOM   73   N N   . SER A 1 31  ? 39.887  -13.646 -0.817  1.00 45.26 ? 31  SER A N   1 
ATOM   74   C CA  . SER A 1 31  ? 40.236  -12.351 -0.259  1.00 51.85 ? 31  SER A CA  1 
ATOM   75   C C   . SER A 1 31  ? 38.969  -11.550 0.030   1.00 50.40 ? 31  SER A C   1 
ATOM   76   O O   . SER A 1 31  ? 39.045  -10.340 0.222   1.00 51.42 ? 31  SER A O   1 
ATOM   77   C CB  . SER A 1 31  ? 41.200  -11.606 -1.156  1.00 53.00 ? 31  SER A CB  1 
ATOM   78   O OG  . SER A 1 31  ? 40.691  -11.513 -2.476  1.00 56.45 ? 31  SER A OG  1 
ATOM   79   N N   . GLN A 1 32  ? 37.819  -12.240 0.091   1.00 47.97 ? 32  GLN A N   1 
ATOM   80   C CA  . GLN A 1 32  ? 36.547  -11.592 0.381   1.00 48.58 ? 32  GLN A CA  1 
ATOM   81   C C   . GLN A 1 32  ? 35.996  -12.158 1.695   1.00 51.28 ? 32  GLN A C   1 
ATOM   82   O O   . GLN A 1 32  ? 36.225  -13.368 1.943   1.00 45.79 ? 32  GLN A O   1 
ATOM   83   C CB  . GLN A 1 32  ? 35.553  -11.756 -0.784  1.00 45.21 ? 32  GLN A CB  1 
ATOM   84   C CG  . GLN A 1 32  ? 36.037  -11.112 -2.093  1.00 44.09 ? 32  GLN A CG  1 
ATOM   85   C CD  . GLN A 1 32  ? 35.040  -11.032 -3.230  1.00 37.91 ? 32  GLN A CD  1 
ATOM   86   O OE1 . GLN A 1 32  ? 35.401  -10.820 -4.382  1.00 45.89 ? 32  GLN A OE1 1 
ATOM   87   N NE2 . GLN A 1 32  ? 33.777  -11.268 -2.948  1.00 39.95 ? 32  GLN A NE2 1 
ATOM   88   N N   . PRO A 1 34  ? 33.278  -11.386 3.910   1.00 37.31 ? 34  PRO A N   1 
ATOM   89   C CA  . PRO A 1 34  ? 32.235  -12.280 4.443   1.00 36.10 ? 34  PRO A CA  1 
ATOM   90   C C   . PRO A 1 34  ? 31.154  -11.493 5.177   1.00 40.70 ? 34  PRO A C   1 
ATOM   91   O O   . PRO A 1 34  ? 30.061  -12.036 5.351   1.00 42.24 ? 34  PRO A O   1 
ATOM   92   C CB  . PRO A 1 34  ? 32.936  -13.284 5.385   1.00 37.48 ? 34  PRO A CB  1 
ATOM   93   C CG  . PRO A 1 34  ? 34.378  -12.798 5.443   1.00 39.79 ? 34  PRO A CG  1 
ATOM   94   C CD  . PRO A 1 34  ? 34.558  -12.099 4.110   1.00 39.33 ? 34  PRO A CD  1 
ATOM   95   N N   . GLY A 1 35  ? 31.553  -10.333 5.749   1.00 40.62 ? 35  GLY A N   1 
ATOM   96   C CA  . GLY A 1 35  ? 30.751  -9.112  5.850   1.00 36.43 ? 35  GLY A CA  1 
ATOM   97   C C   . GLY A 1 35  ? 31.653  -7.863  5.874   1.00 36.47 ? 35  GLY A C   1 
ATOM   98   O O   . GLY A 1 35  ? 31.462  -6.930  6.643   1.00 34.93 ? 35  GLY A O   1 
ATOM   99   N N   . GLY A 1 36  ? 32.700  -7.841  5.045   1.00 33.30 ? 36  GLY A N   1 
ATOM   100  C CA  . GLY A 1 36  ? 33.713  -6.797  5.140   1.00 35.41 ? 36  GLY A CA  1 
ATOM   101  C C   . GLY A 1 36  ? 33.319  -5.539  4.366   1.00 34.53 ? 36  GLY A C   1 
ATOM   102  O O   . GLY A 1 36  ? 32.210  -5.465  3.838   1.00 37.57 ? 36  GLY A O   1 
ATOM   103  N N   . SER A 1 37  ? 34.226  -4.552  4.352   1.00 29.14 ? 37  SER A N   1 
ATOM   104  C CA  . SER A 1 37  ? 34.224  -3.482  3.370   1.00 26.76 ? 37  SER A CA  1 
ATOM   105  C C   . SER A 1 37  ? 34.034  -4.105  1.997   1.00 23.38 ? 37  SER A C   1 
ATOM   106  O O   . SER A 1 37  ? 34.490  -5.230  1.787   1.00 21.41 ? 37  SER A O   1 
ATOM   107  C CB  . SER A 1 37  ? 35.514  -2.702  3.400   1.00 28.24 ? 37  SER A CB  1 
ATOM   108  O OG  . SER A 1 37  ? 35.687  -2.099  4.660   1.00 32.21 ? 37  SER A OG  1 
ATOM   109  N N   . SER A 1 38  ? 33.394  -3.371  1.070   1.00 19.80 ? 38  SER A N   1 
ATOM   110  C CA  . SER A 1 38  ? 33.241  -3.883  -0.282  1.00 16.92 ? 38  SER A CA  1 
ATOM   111  C C   . SER A 1 38  ? 34.624  -4.086  -0.907  1.00 17.12 ? 38  SER A C   1 
ATOM   112  O O   . SER A 1 38  ? 35.578  -3.408  -0.520  1.00 15.55 ? 38  SER A O   1 
ATOM   113  C CB  . SER A 1 38  ? 32.372  -2.976  -1.122  1.00 15.24 ? 38  SER A CB  1 
ATOM   114  O OG  . SER A 1 38  ? 32.991  -1.701  -1.305  1.00 14.26 ? 38  SER A OG  1 
ATOM   115  N N   . TYR A 1 39  ? 34.712  -5.023  -1.868  1.00 16.60 ? 39  TYR A N   1 
ATOM   116  C CA  . TYR A 1 39  ? 35.952  -5.422  -2.528  1.00 18.12 ? 39  TYR A CA  1 
ATOM   117  C C   . TYR A 1 39  ? 35.845  -5.099  -4.019  1.00 15.52 ? 39  TYR A C   1 
ATOM   118  O O   . TYR A 1 39  ? 34.779  -5.316  -4.641  1.00 13.19 ? 39  TYR A O   1 
ATOM   119  C CB  . TYR A 1 39  ? 36.211  -6.934  -2.420  1.00 24.76 ? 39  TYR A CB  1 
ATOM   120  C CG  . TYR A 1 39  ? 35.882  -7.573  -1.079  1.00 37.42 ? 39  TYR A CG  1 
ATOM   121  C CD1 . TYR A 1 39  ? 36.769  -7.499  0.008   1.00 48.22 ? 39  TYR A CD1 1 
ATOM   122  C CD2 . TYR A 1 39  ? 34.681  -8.263  -0.891  1.00 44.28 ? 39  TYR A CD2 1 
ATOM   123  C CE1 . TYR A 1 39  ? 36.467  -8.075  1.239   1.00 49.45 ? 39  TYR A CE1 1 
ATOM   124  C CE2 . TYR A 1 39  ? 34.370  -8.834  0.340   1.00 52.58 ? 39  TYR A CE2 1 
ATOM   125  C CZ  . TYR A 1 39  ? 35.260  -8.741  1.404   1.00 54.17 ? 39  TYR A CZ  1 
ATOM   126  O OH  . TYR A 1 39  ? 34.943  -9.320  2.603   1.00 64.98 ? 39  TYR A OH  1 
ATOM   127  N N   . GLY A 1 40  ? 36.932  -4.548  -4.593  1.00 13.26 ? 40  GLY A N   1 
ATOM   128  C CA  . GLY A 1 40  ? 36.957  -4.198  -6.004  1.00 12.29 ? 40  GLY A CA  1 
ATOM   129  C C   . GLY A 1 40  ? 37.468  -5.353  -6.860  1.00 12.36 ? 40  GLY A C   1 
ATOM   130  O O   . GLY A 1 40  ? 38.460  -5.985  -6.492  1.00 11.64 ? 40  GLY A O   1 
ATOM   131  N N   . VAL A 1 41  ? 36.824  -5.604  -8.014  1.00 12.01 ? 41  VAL A N   1 
ATOM   132  C CA  . VAL A 1 41  ? 37.152  -6.762  -8.844  1.00 11.76 ? 41  VAL A CA  1 
ATOM   133  C C   . VAL A 1 41  ? 37.174  -6.365  -10.317 1.00 11.37 ? 41  VAL A C   1 
ATOM   134  O O   . VAL A 1 41  ? 36.193  -5.820  -10.822 1.00 9.92  ? 41  VAL A O   1 
ATOM   135  C CB  . VAL A 1 41  ? 36.111  -7.883  -8.643  1.00 12.69 ? 41  VAL A CB  1 
ATOM   136  C CG1 . VAL A 1 41  ? 36.374  -9.101  -9.533  1.00 14.12 ? 41  VAL A CG1 1 
ATOM   137  C CG2 . VAL A 1 41  ? 36.000  -8.307  -7.190  1.00 14.04 ? 41  VAL A CG2 1 
ATOM   138  N N   . ASN A 1 42  ? 38.251  -6.736  -11.025 1.00 11.69 ? 42  ASN A N   1 
ATOM   139  C CA  . ASN A 1 42  ? 38.284  -6.669  -12.469 1.00 12.93 ? 42  ASN A CA  1 
ATOM   140  C C   . ASN A 1 42  ? 37.613  -7.903  -13.070 1.00 13.16 ? 42  ASN A C   1 
ATOM   141  O O   . ASN A 1 42  ? 37.723  -9.027  -12.562 1.00 13.94 ? 42  ASN A O   1 
ATOM   142  C CB  . ASN A 1 42  ? 39.701  -6.525  -12.999 1.00 16.52 ? 42  ASN A CB  1 
ATOM   143  C CG  . ASN A 1 42  ? 40.299  -5.159  -12.765 1.00 19.76 ? 42  ASN A CG  1 
ATOM   144  O OD1 . ASN A 1 42  ? 39.587  -4.148  -12.758 1.00 17.51 ? 42  ASN A OD1 1 
ATOM   145  N ND2 . ASN A 1 42  ? 41.609  -5.138  -12.563 1.00 26.63 ? 42  ASN A ND2 1 
ATOM   146  N N   . PHE A 1 43  ? 36.869  -7.676  -14.160 1.00 14.03 ? 43  PHE A N   1 
ATOM   147  C CA  . PHE A 1 43  ? 36.054  -8.700  -14.801 1.00 12.92 ? 43  PHE A CA  1 
ATOM   148  C C   . PHE A 1 43  ? 36.024  -8.437  -16.305 1.00 12.76 ? 43  PHE A C   1 
ATOM   149  O O   . PHE A 1 43  ? 35.541  -7.383  -16.722 1.00 11.18 ? 43  PHE A O   1 
ATOM   150  C CB  . PHE A 1 43  ? 34.637  -8.677  -14.232 1.00 12.84 ? 43  PHE A CB  1 
ATOM   151  C CG  . PHE A 1 43  ? 33.705  -9.717  -14.805 1.00 11.78 ? 43  PHE A CG  1 
ATOM   152  C CD1 . PHE A 1 43  ? 33.951  -11.075 -14.630 1.00 11.70 ? 43  PHE A CD1 1 
ATOM   153  C CD2 . PHE A 1 43  ? 32.592  -9.338  -15.526 1.00 12.21 ? 43  PHE A CD2 1 
ATOM   154  C CE1 . PHE A 1 43  ? 33.121  -12.031 -15.203 1.00 11.74 ? 43  PHE A CE1 1 
ATOM   155  C CE2 . PHE A 1 43  ? 31.728  -10.291 -16.066 1.00 12.94 ? 43  PHE A CE2 1 
ATOM   156  C CZ  . PHE A 1 43  ? 31.992  -11.635 -15.897 1.00 12.63 ? 43  PHE A CZ  1 
ATOM   157  N N   . THR A 1 44  ? 36.534  -9.404  -17.095 1.00 12.36 ? 44  THR A N   1 
ATOM   158  C CA  . THR A 1 44  ? 36.662  -9.249  -18.532 1.00 11.64 ? 44  THR A CA  1 
ATOM   159  C C   . THR A 1 44  ? 35.528  -9.976  -19.240 1.00 11.25 ? 44  THR A C   1 
ATOM   160  O O   . THR A 1 44  ? 35.374  -11.193 -19.139 1.00 11.23 ? 44  THR A O   1 
ATOM   161  C CB  . THR A 1 44  ? 38.065  -9.680  -19.013 1.00 11.77 ? 44  THR A CB  1 
ATOM   162  O OG1 . THR A 1 44  ? 39.027  -8.996  -18.211 1.00 12.04 ? 44  THR A OG1 1 
ATOM   163  C CG2 . THR A 1 44  ? 38.315  -9.372  -20.472 1.00 11.95 ? 44  THR A CG2 1 
ATOM   164  N N   . LEU A 1 45  ? 34.788  -9.212  -20.040 1.00 10.97 ? 45  LEU A N   1 
ATOM   165  C CA  . LEU A 1 45  ? 33.658  -9.738  -20.785 1.00 10.96 ? 45  LEU A CA  1 
ATOM   166  C C   . LEU A 1 45  ? 34.139  -10.662 -21.915 1.00 11.61 ? 45  LEU A C   1 
ATOM   167  O O   . LEU A 1 45  ? 35.266  -10.573 -22.407 1.00 11.07 ? 45  LEU A O   1 
ATOM   168  C CB  . LEU A 1 45  ? 32.828  -8.576  -21.321 1.00 10.39 ? 45  LEU A CB  1 
ATOM   169  C CG  . LEU A 1 45  ? 32.412  -7.510  -20.306 1.00 10.85 ? 45  LEU A CG  1 
ATOM   170  C CD1 . LEU A 1 45  ? 31.511  -6.505  -20.961 1.00 10.28 ? 45  LEU A CD1 1 
ATOM   171  C CD2 . LEU A 1 45  ? 31.706  -8.135  -19.112 1.00 11.38 ? 45  LEU A CD2 1 
ATOM   172  N N   . SER A 1 46  ? 33.244  -11.573 -22.293 1.00 11.39 ? 46  SER A N   1 
ATOM   173  C CA  . SER A 1 46  ? 33.509  -12.546 -23.336 1.00 11.57 ? 46  SER A CA  1 
ATOM   174  C C   . SER A 1 46  ? 34.221  -11.908 -24.534 1.00 11.78 ? 46  SER A C   1 
ATOM   175  O O   . SER A 1 46  ? 35.184  -12.469 -25.046 1.00 11.12 ? 46  SER A O   1 
ATOM   176  C CB  . SER A 1 46  ? 32.225  -13.219 -23.736 1.00 11.64 ? 46  SER A CB  1 
ATOM   177  O OG  . SER A 1 46  ? 32.489  -14.305 -24.621 1.00 12.96 ? 46  SER A OG  1 
ATOM   178  N N   . ALA A 1 47  ? 33.730  -10.751 -24.978 1.00 12.64 ? 47  ALA A N   1 
ATOM   179  C CA  . ALA A 1 47  ? 34.208  -10.107 -26.197 1.00 13.45 ? 47  ALA A CA  1 
ATOM   180  C C   . ALA A 1 47  ? 35.433  -9.249  -25.929 1.00 12.52 ? 47  ALA A C   1 
ATOM   181  O O   . ALA A 1 47  ? 36.036  -8.688  -26.836 1.00 13.36 ? 47  ALA A O   1 
ATOM   182  C CB  . ALA A 1 47  ? 33.073  -9.322  -26.815 1.00 14.44 ? 47  ALA A CB  1 
ATOM   183  N N   . GLY A 1 48  ? 35.838  -9.153  -24.677 1.00 11.81 ? 48  GLY A N   1 
ATOM   184  C CA  . GLY A 1 48  ? 37.193  -8.703  -24.391 1.00 12.56 ? 48  GLY A CA  1 
ATOM   185  C C   . GLY A 1 48  ? 37.329  -7.389  -23.618 1.00 12.21 ? 48  GLY A C   1 
ATOM   186  O O   . GLY A 1 48  ? 38.444  -7.035  -23.264 1.00 11.78 ? 48  GLY A O   1 
ATOM   187  N N   . THR A 1 49  ? 36.247  -6.655  -23.326 1.00 11.09 ? 49  THR A N   1 
ATOM   188  C CA  . THR A 1 49  ? 36.439  -5.410  -22.588 1.00 11.03 ? 49  THR A CA  1 
ATOM   189  C C   . THR A 1 49  ? 36.629  -5.711  -21.108 1.00 10.08 ? 49  THR A C   1 
ATOM   190  O O   . THR A 1 49  ? 35.793  -6.394  -20.526 1.00 9.93  ? 49  THR A O   1 
ATOM   191  C CB  . THR A 1 49  ? 35.244  -4.462  -22.696 1.00 10.95 ? 49  THR A CB  1 
ATOM   192  O OG1 . THR A 1 49  ? 34.956  -4.241  -24.065 1.00 13.10 ? 49  THR A OG1 1 
ATOM   193  C CG2 . THR A 1 49  ? 35.467  -3.131  -22.026 1.00 11.77 ? 49  THR A CG2 1 
ATOM   194  N N   . GLN A 1 50  ? 37.687  -5.175  -20.494 1.00 10.43 ? 50  GLN A N   1 
ATOM   195  C CA  . GLN A 1 50  ? 37.875  -5.319  -19.055 1.00 11.45 ? 50  GLN A CA  1 
ATOM   196  C C   . GLN A 1 50  ? 36.976  -4.308  -18.344 1.00 10.86 ? 50  GLN A C   1 
ATOM   197  O O   . GLN A 1 50  ? 37.026  -3.106  -18.659 1.00 10.64 ? 50  GLN A O   1 
ATOM   198  C CB  . GLN A 1 50  ? 39.324  -5.068  -18.616 1.00 13.03 ? 50  GLN A CB  1 
ATOM   199  C CG  . GLN A 1 50  ? 39.499  -5.373  -17.150 1.00 14.77 ? 50  GLN A CG  1 
ATOM   200  C CD  . GLN A 1 50  ? 40.868  -5.040  -16.618 1.00 17.70 ? 50  GLN A CD  1 
ATOM   201  O OE1 . GLN A 1 50  ? 41.609  -5.894  -16.128 1.00 22.19 ? 50  GLN A OE1 1 
ATOM   202  N NE2 . GLN A 1 50  ? 41.212  -3.785  -16.730 1.00 19.67 ? 50  GLN A NE2 1 
ATOM   203  N N   . ARG A 1 51  ? 36.171  -4.804  -17.400 1.00 10.99 ? 51  ARG A N   1 
ATOM   204  C CA  . ARG A 1 51  ? 35.246  -3.959  -16.638 1.00 10.80 ? 51  ARG A CA  1 
ATOM   205  C C   . ARG A 1 51  ? 35.582  -4.115  -15.159 1.00 10.93 ? 51  ARG A C   1 
ATOM   206  O O   . ARG A 1 51  ? 36.441  -4.921  -14.804 1.00 11.30 ? 51  ARG A O   1 
ATOM   207  C CB  . ARG A 1 51  ? 33.777  -4.318  -16.930 1.00 10.63 ? 51  ARG A CB  1 
ATOM   208  C CG  . ARG A 1 51  ? 33.334  -4.195  -18.385 1.00 9.75  ? 51  ARG A CG  1 
ATOM   209  C CD  . ARG A 1 51  ? 33.471  -2.756  -18.890 1.00 10.63 ? 51  ARG A CD  1 
ATOM   210  N NE  . ARG A 1 51  ? 32.626  -1.800  -18.158 1.00 11.04 ? 51  ARG A NE  1 
ATOM   211  C CZ  . ARG A 1 51  ? 31.432  -1.348  -18.534 1.00 11.61 ? 51  ARG A CZ  1 
ATOM   212  N NH1 . ARG A 1 51  ? 30.815  -1.835  -19.600 1.00 12.73 ? 51  ARG A NH1 1 
ATOM   213  N NH2 . ARG A 1 51  ? 30.825  -0.430  -17.798 1.00 10.95 ? 51  ARG A NH2 1 
ATOM   214  N N   . PHE A 1 52  ? 34.887  -3.340  -14.295 1.00 11.13 ? 52  PHE A N   1 
ATOM   215  C CA  . PHE A 1 52  ? 35.158  -3.312  -12.869 1.00 11.00 ? 52  PHE A CA  1 
ATOM   216  C C   . PHE A 1 52  ? 33.862  -3.157  -12.073 1.00 10.37 ? 52  PHE A C   1 
ATOM   217  O O   . PHE A 1 52  ? 32.950  -2.437  -12.490 1.00 10.12 ? 52  PHE A O   1 
ATOM   218  C CB  . PHE A 1 52  ? 36.146  -2.197  -12.533 1.00 11.77 ? 52  PHE A CB  1 
ATOM   219  C CG  . PHE A 1 52  ? 36.450  -1.968  -11.068 1.00 11.73 ? 52  PHE A CG  1 
ATOM   220  C CD1 . PHE A 1 52  ? 35.734  -1.052  -10.318 1.00 12.19 ? 52  PHE A CD1 1 
ATOM   221  C CD2 . PHE A 1 52  ? 37.491  -2.639  -10.441 1.00 11.59 ? 52  PHE A CD2 1 
ATOM   222  C CE1 . PHE A 1 52  ? 36.036  -0.822  -8.976  1.00 12.42 ? 52  PHE A CE1 1 
ATOM   223  C CE2 . PHE A 1 52  ? 37.784  -2.406  -9.101  1.00 12.44 ? 52  PHE A CE2 1 
ATOM   224  C CZ  . PHE A 1 52  ? 37.062  -1.497  -8.372  1.00 12.37 ? 52  PHE A CZ  1 
ATOM   225  N N   . TYR A 1 53  ? 33.835  -3.791  -10.894 1.00 9.88  ? 53  TYR A N   1 
ATOM   226  C CA  . TYR A 1 53  ? 32.735  -3.617  -9.948  1.00 10.24 ? 53  TYR A CA  1 
ATOM   227  C C   . TYR A 1 53  ? 33.272  -3.734  -8.528  1.00 10.71 ? 53  TYR A C   1 
ATOM   228  O O   . TYR A 1 53  ? 34.356  -4.282  -8.303  1.00 10.80 ? 53  TYR A O   1 
ATOM   229  C CB  . TYR A 1 53  ? 31.581  -4.599  -10.139 1.00 9.89  ? 53  TYR A CB  1 
ATOM   230  C CG  . TYR A 1 53  ? 31.967  -6.062  -9.938  1.00 9.78  ? 53  TYR A CG  1 
ATOM   231  C CD1 . TYR A 1 53  ? 32.006  -6.636  -8.676  1.00 9.28  ? 53  TYR A CD1 1 
ATOM   232  C CD2 . TYR A 1 53  ? 32.356  -6.854  -11.015 1.00 9.92  ? 53  TYR A CD2 1 
ATOM   233  C CE1 . TYR A 1 53  ? 32.388  -7.952  -8.486  1.00 9.70  ? 53  TYR A CE1 1 
ATOM   234  C CE2 . TYR A 1 53  ? 32.673  -8.195  -10.841 1.00 10.56 ? 53  TYR A CE2 1 
ATOM   235  C CZ  . TYR A 1 53  ? 32.684  -8.748  -9.580  1.00 10.89 ? 53  TYR A CZ  1 
ATOM   236  O OH  . TYR A 1 53  ? 33.067  -10.043 -9.397  1.00 12.60 ? 53  TYR A OH  1 
ATOM   237  N N   . ARG A 1 54  ? 32.510  -3.168  -7.588  1.00 10.88 ? 54  ARG A N   1 
ATOM   238  C CA  . ARG A 1 54  ? 32.714  -3.413  -6.168  1.00 11.36 ? 54  ARG A CA  1 
ATOM   239  C C   . ARG A 1 54  ? 31.569  -4.269  -5.664  1.00 10.32 ? 54  ARG A C   1 
ATOM   240  O O   . ARG A 1 54  ? 30.443  -4.142  -6.142  1.00 10.66 ? 54  ARG A O   1 
ATOM   241  C CB  . ARG A 1 54  ? 32.758  -2.122  -5.341  1.00 12.35 ? 54  ARG A CB  1 
ATOM   242  C CG  . ARG A 1 54  ? 33.905  -1.184  -5.669  1.00 14.75 ? 54  ARG A CG  1 
ATOM   243  C CD  . ARG A 1 54  ? 34.081  -0.133  -4.568  1.00 17.93 ? 54  ARG A CD  1 
ATOM   244  N NE  . ARG A 1 54  ? 34.820  -0.680  -3.434  1.00 21.57 ? 54  ARG A NE  1 
ATOM   245  C CZ  . ARG A 1 54  ? 36.127  -0.975  -3.458  1.00 24.11 ? 54  ARG A CZ  1 
ATOM   246  N NH1 . ARG A 1 54  ? 36.884  -0.583  -4.467  1.00 22.62 ? 54  ARG A NH1 1 
ATOM   247  N NH2 . ARG A 1 54  ? 36.690  -1.660  -2.474  1.00 25.37 ? 54  ARG A NH2 1 
ATOM   248  N N   . ILE A 1 55  ? 31.879  -5.211  -4.767  1.00 9.65  ? 55  ILE A N   1 
ATOM   249  C CA  . ILE A 1 55  ? 30.899  -6.176  -4.279  1.00 10.45 ? 55  ILE A CA  1 
ATOM   250  C C   . ILE A 1 55  ? 30.939  -6.186  -2.749  1.00 10.61 ? 55  ILE A C   1 
ATOM   251  O O   . ILE A 1 55  ? 32.020  -6.306  -2.155  1.00 10.97 ? 55  ILE A O   1 
ATOM   252  C CB  . ILE A 1 55  ? 31.141  -7.604  -4.817  1.00 10.91 ? 55  ILE A CB  1 
ATOM   253  C CG1 . ILE A 1 55  ? 30.076  -8.555  -4.258  1.00 11.11 ? 55  ILE A CG1 1 
ATOM   254  C CG2 . ILE A 1 55  ? 32.559  -8.102  -4.512  1.00 11.07 ? 55  ILE A CG2 1 
ATOM   255  C CD1 . ILE A 1 55  ? 29.923  -9.850  -5.044  1.00 12.14 ? 55  ILE A CD1 1 
ATOM   256  N N   . HIS A 1 56  ? 29.755  -6.147  -2.145  1.00 11.70 ? 56  HIS A N   1 
ATOM   257  C CA  . HIS A 1 56  ? 29.608  -6.234  -0.704  1.00 12.16 ? 56  HIS A CA  1 
ATOM   258  C C   . HIS A 1 56  ? 28.902  -7.549  -0.414  1.00 12.77 ? 56  HIS A C   1 
ATOM   259  O O   . HIS A 1 56  ? 27.827  -7.804  -0.969  1.00 13.11 ? 56  HIS A O   1 
ATOM   260  C CB  . HIS A 1 56  ? 28.748  -5.075  -0.188  1.00 14.01 ? 56  HIS A CB  1 
ATOM   261  C CG  . HIS A 1 56  ? 28.624  -5.122  1.278   1.00 15.16 ? 56  HIS A CG  1 
ATOM   262  N ND1 . HIS A 1 56  ? 27.568  -5.698  1.902   1.00 17.49 ? 56  HIS A ND1 1 
ATOM   263  C CD2 . HIS A 1 56  ? 29.498  -4.780  2.243   1.00 21.29 ? 56  HIS A CD2 1 
ATOM   264  C CE1 . HIS A 1 56  ? 27.763  -5.669  3.211   1.00 19.16 ? 56  HIS A CE1 1 
ATOM   265  N NE2 . HIS A 1 56  ? 28.925  -5.117  3.447   1.00 19.11 ? 56  HIS A NE2 1 
ATOM   266  N N   . ILE A 1 57  ? 29.485  -8.360  0.479   1.00 11.95 ? 57  ILE A N   1 
ATOM   267  C CA  . ILE A 1 57  ? 28.867  -9.613  0.879   1.00 12.88 ? 57  ILE A CA  1 
ATOM   268  C C   . ILE A 1 57  ? 28.196  -9.422  2.241   1.00 13.54 ? 57  ILE A C   1 
ATOM   269  O O   . ILE A 1 57  ? 28.858  -8.973  3.174   1.00 11.39 ? 57  ILE A O   1 
ATOM   270  C CB  . ILE A 1 57  ? 29.927  -10.729 0.968   1.00 13.81 ? 57  ILE A CB  1 
ATOM   271  C CG1 . ILE A 1 57  ? 30.700  -10.941 -0.333  1.00 14.87 ? 57  ILE A CG1 1 
ATOM   272  C CG2 . ILE A 1 57  ? 29.296  -12.017 1.450   1.00 14.09 ? 57  ILE A CG2 1 
ATOM   273  C CD1 . ILE A 1 57  ? 29.810  -11.237 -1.518  1.00 16.01 ? 57  ILE A CD1 1 
ATOM   274  N N   . PRO A 1 58  ? 26.907  -9.782  2.444   1.00 13.85 ? 58  PRO A N   1 
ATOM   275  C CA  . PRO A 1 58  ? 26.276  -9.546  3.754   1.00 14.77 ? 58  PRO A CA  1 
ATOM   276  C C   . PRO A 1 58  ? 26.947  -10.407 4.839   1.00 17.07 ? 58  PRO A C   1 
ATOM   277  O O   . PRO A 1 58  ? 27.382  -11.535 4.561   1.00 16.74 ? 58  PRO A O   1 
ATOM   278  C CB  . PRO A 1 58  ? 24.800  -9.909  3.509   1.00 14.39 ? 58  PRO A CB  1 
ATOM   279  C CG  . PRO A 1 58  ? 24.825  -10.850 2.357   1.00 14.41 ? 58  PRO A CG  1 
ATOM   280  C CD  . PRO A 1 58  ? 25.996  -10.430 1.494   1.00 13.51 ? 58  PRO A CD  1 
ATOM   281  N N   . SER A 1 59  ? 27.069  -9.872  6.065   1.00 17.01 ? 59  SER A N   1 
ATOM   282  C CA  . SER A 1 59  ? 27.724  -10.607 7.135   1.00 18.04 ? 59  SER A CA  1 
ATOM   283  C C   . SER A 1 59  ? 27.002  -11.925 7.447   1.00 18.15 ? 59  SER A C   1 
ATOM   284  O O   . SER A 1 59  ? 27.641  -12.841 7.919   1.00 17.71 ? 59  SER A O   1 
ATOM   285  C CB  . SER A 1 59  ? 27.926  -9.735  8.357   1.00 20.00 ? 59  SER A CB  1 
ATOM   286  O OG  . SER A 1 59  ? 26.682  -9.334  8.880   1.00 20.46 ? 59  SER A OG  1 
ATOM   287  N N   . ASN A 1 60  ? 25.718  -12.095 7.093   1.00 17.35 ? 60  ASN A N   1 
ATOM   288  C CA  . ASN A 1 60  ? 25.006  -13.342 7.359   1.00 16.96 ? 60  ASN A CA  1 
ATOM   289  C C   . ASN A 1 60  ? 25.049  -14.315 6.171   1.00 15.37 ? 60  ASN A C   1 
ATOM   290  O O   . ASN A 1 60  ? 24.352  -15.302 6.141   1.00 14.42 ? 60  ASN A O   1 
ATOM   291  C CB  . ASN A 1 60  ? 23.563  -13.056 7.743   1.00 18.02 ? 60  ASN A CB  1 
ATOM   292  C CG  . ASN A 1 60  ? 22.758  -12.502 6.591   1.00 20.35 ? 60  ASN A CG  1 
ATOM   293  O OD1 . ASN A 1 60  ? 23.222  -12.407 5.450   1.00 18.94 ? 60  ASN A OD1 1 
ATOM   294  N ND2 . ASN A 1 60  ? 21.552  -12.095 6.904   1.00 20.77 ? 60  ASN A ND2 1 
ATOM   295  N N   . TYR A 1 61  ? 25.846  -14.023 5.153   1.00 16.25 ? 61  TYR A N   1 
ATOM   296  C CA  . TYR A 1 61  ? 25.948  -14.872 3.980   1.00 15.13 ? 61  TYR A CA  1 
ATOM   297  C C   . TYR A 1 61  ? 26.285  -16.307 4.388   1.00 15.33 ? 61  TYR A C   1 
ATOM   298  O O   . TYR A 1 61  ? 27.150  -16.547 5.225   1.00 15.18 ? 61  TYR A O   1 
ATOM   299  C CB  . TYR A 1 61  ? 27.036  -14.346 3.027   1.00 14.81 ? 61  TYR A CB  1 
ATOM   300  C CG  . TYR A 1 61  ? 27.176  -15.192 1.770   1.00 15.10 ? 61  TYR A CG  1 
ATOM   301  C CD1 . TYR A 1 61  ? 26.163  -15.247 0.816   1.00 15.76 ? 61  TYR A CD1 1 
ATOM   302  C CD2 . TYR A 1 61  ? 28.305  -15.970 1.553   1.00 16.85 ? 61  TYR A CD2 1 
ATOM   303  C CE1 . TYR A 1 61  ? 26.291  -16.009 -0.335  1.00 15.70 ? 61  TYR A CE1 1 
ATOM   304  C CE2 . TYR A 1 61  ? 28.429  -16.756 0.416   1.00 17.54 ? 61  TYR A CE2 1 
ATOM   305  C CZ  . TYR A 1 61  ? 27.429  -16.760 -0.544  1.00 16.16 ? 61  TYR A CZ  1 
ATOM   306  O OH  . TYR A 1 61  ? 27.590  -17.567 -1.630  1.00 15.63 ? 61  TYR A OH  1 
ATOM   307  N N   . ASN A 1 62  ? 25.583  -17.249 3.779   1.00 14.46 ? 62  ASN A N   1 
ATOM   308  C CA  . ASN A 1 62  ? 25.853  -18.660 3.954   1.00 15.94 ? 62  ASN A CA  1 
ATOM   309  C C   . ASN A 1 62  ? 25.929  -19.278 2.567   1.00 13.99 ? 62  ASN A C   1 
ATOM   310  O O   . ASN A 1 62  ? 25.022  -19.053 1.776   1.00 12.86 ? 62  ASN A O   1 
ATOM   311  C CB  . ASN A 1 62  ? 24.743  -19.339 4.749   1.00 17.90 ? 62  ASN A CB  1 
ATOM   312  C CG  . ASN A 1 62  ? 25.031  -20.807 4.897   1.00 20.86 ? 62  ASN A CG  1 
ATOM   313  O OD1 . ASN A 1 62  ? 24.602  -21.606 4.089   1.00 18.68 ? 62  ASN A OD1 1 
ATOM   314  N ND2 . ASN A 1 62  ? 25.863  -21.143 5.860   1.00 26.69 ? 62  ASN A ND2 1 
ATOM   315  N N   . VAL A 1 63  ? 26.977  -20.071 2.299   1.00 14.38 ? 63  VAL A N   1 
ATOM   316  C CA  . VAL A 1 63  ? 27.244  -20.562 0.947   1.00 15.25 ? 63  VAL A CA  1 
ATOM   317  C C   . VAL A 1 63  ? 26.148  -21.524 0.484   1.00 14.55 ? 63  VAL A C   1 
ATOM   318  O O   . VAL A 1 63  ? 26.099  -21.817 -0.712  1.00 15.10 ? 63  VAL A O   1 
ATOM   319  C CB  . VAL A 1 63  ? 28.637  -21.213 0.806   1.00 15.60 ? 63  VAL A CB  1 
ATOM   320  C CG1 . VAL A 1 63  ? 29.744  -20.261 1.232   1.00 16.33 ? 63  VAL A CG1 1 
ATOM   321  C CG2 . VAL A 1 63  ? 28.730  -22.539 1.548   1.00 17.21 ? 63  VAL A CG2 1 
ATOM   322  N N   . ASN A 1 64  ? 25.281  -22.014 1.388   1.00 13.72 ? 64  ASN A N   1 
ATOM   323  C CA  . ASN A 1 64  ? 24.222  -22.932 0.996   1.00 17.17 ? 64  ASN A CA  1 
ATOM   324  C C   . ASN A 1 64  ? 22.858  -22.234 0.937   1.00 16.75 ? 64  ASN A C   1 
ATOM   325  O O   . ASN A 1 64  ? 21.882  -22.878 0.624   1.00 15.68 ? 64  ASN A O   1 
ATOM   326  C CB  . ASN A 1 64  ? 24.139  -24.139 1.945   1.00 19.61 ? 64  ASN A CB  1 
ATOM   327  C CG  . ASN A 1 64  ? 25.465  -24.868 2.050   1.00 20.39 ? 64  ASN A CG  1 
ATOM   328  O OD1 . ASN A 1 64  ? 26.076  -24.937 3.111   1.00 28.34 ? 64  ASN A OD1 1 
ATOM   329  N ND2 . ASN A 1 64  ? 25.949  -25.342 0.930   1.00 18.67 ? 64  ASN A ND2 1 
ATOM   330  N N   . THR A 1 65  ? 22.772  -20.943 1.273   1.00 16.77 ? 65  THR A N   1 
ATOM   331  C CA  . THR A 1 65  ? 21.489  -20.279 1.375   1.00 16.46 ? 65  THR A CA  1 
ATOM   332  C C   . THR A 1 65  ? 21.309  -19.392 0.147   1.00 15.36 ? 65  THR A C   1 
ATOM   333  O O   . THR A 1 65  ? 22.173  -18.568 -0.127  1.00 14.08 ? 65  THR A O   1 
ATOM   334  C CB  . THR A 1 65  ? 21.368  -19.442 2.656   1.00 18.45 ? 65  THR A CB  1 
ATOM   335  O OG1 . THR A 1 65  ? 21.552  -20.328 3.765   1.00 19.73 ? 65  THR A OG1 1 
ATOM   336  C CG2 . THR A 1 65  ? 20.019  -18.755 2.770   1.00 17.65 ? 65  THR A CG2 1 
ATOM   337  N N   . PRO A 1 66  ? 20.258  -19.595 -0.680  1.00 14.76 ? 66  PRO A N   1 
ATOM   338  C CA  . PRO A 1 66  ? 20.027  -18.738 -1.848  1.00 15.14 ? 66  PRO A CA  1 
ATOM   339  C C   . PRO A 1 66  ? 19.891  -17.284 -1.409  1.00 13.26 ? 66  PRO A C   1 
ATOM   340  O O   . PRO A 1 66  ? 19.069  -16.972 -0.545  1.00 13.22 ? 66  PRO A O   1 
ATOM   341  C CB  . PRO A 1 66  ? 18.741  -19.302 -2.477  1.00 15.66 ? 66  PRO A CB  1 
ATOM   342  C CG  . PRO A 1 66  ? 18.813  -20.771 -2.090  1.00 16.31 ? 66  PRO A CG  1 
ATOM   343  C CD  . PRO A 1 66  ? 19.303  -20.716 -0.643  1.00 16.17 ? 66  PRO A CD  1 
ATOM   344  N N   . THR A 1 67  ? 20.740  -16.426 -1.973  1.00 11.49 ? 67  THR A N   1 
ATOM   345  C CA  . THR A 1 67  ? 20.902  -15.057 -1.497  1.00 11.33 ? 67  THR A CA  1 
ATOM   346  C C   . THR A 1 67  ? 20.442  -14.055 -2.558  1.00 10.92 ? 67  THR A C   1 
ATOM   347  O O   . THR A 1 67  ? 20.807  -14.162 -3.734  1.00 10.00 ? 67  THR A O   1 
ATOM   348  C CB  . THR A 1 67  ? 22.375  -14.791 -1.159  1.00 11.46 ? 67  THR A CB  1 
ATOM   349  O OG1 . THR A 1 67  ? 22.838  -15.784 -0.234  1.00 12.38 ? 67  THR A OG1 1 
ATOM   350  C CG2 . THR A 1 67  ? 22.615  -13.431 -0.554  1.00 11.05 ? 67  THR A CG2 1 
ATOM   351  N N   . PRO A 1 68  ? 19.643  -13.039 -2.187  1.00 11.02 ? 68  PRO A N   1 
ATOM   352  C CA  . PRO A 1 68  ? 19.287  -11.973 -3.135  1.00 10.30 ? 68  PRO A CA  1 
ATOM   353  C C   . PRO A 1 68  ? 20.478  -11.087 -3.525  1.00 9.58  ? 68  PRO A C   1 
ATOM   354  O O   . PRO A 1 68  ? 21.507  -11.040 -2.833  1.00 8.41  ? 68  PRO A O   1 
ATOM   355  C CB  . PRO A 1 68  ? 18.246  -11.134 -2.380  1.00 11.30 ? 68  PRO A CB  1 
ATOM   356  C CG  . PRO A 1 68  ? 18.268  -11.568 -0.945  1.00 12.53 ? 68  PRO A CG  1 
ATOM   357  C CD  . PRO A 1 68  ? 19.090  -12.835 -0.842  1.00 11.52 ? 68  PRO A CD  1 
ATOM   358  N N   . LEU A 1 69  ? 20.336  -10.392 -4.658  1.00 9.21  ? 69  LEU A N   1 
ATOM   359  C CA  . LEU A 1 69  ? 21.406  -9.560  -5.172  1.00 9.38  ? 69  LEU A CA  1 
ATOM   360  C C   . LEU A 1 69  ? 20.844  -8.257  -5.735  1.00 8.72  ? 69  LEU A C   1 
ATOM   361  O O   . LEU A 1 69  ? 19.856  -8.278  -6.473  1.00 7.87  ? 69  LEU A O   1 
ATOM   362  C CB  . LEU A 1 69  ? 22.225  -10.365 -6.190  1.00 9.83  ? 69  LEU A CB  1 
ATOM   363  C CG  . LEU A 1 69  ? 23.554  -9.713  -6.601  1.00 11.34 ? 69  LEU A CG  1 
ATOM   364  C CD1 . LEU A 1 69  ? 24.620  -10.731 -6.971  1.00 12.85 ? 69  LEU A CD1 1 
ATOM   365  C CD2 . LEU A 1 69  ? 23.318  -8.801  -7.761  1.00 11.54 ? 69  LEU A CD2 1 
ATOM   366  N N   . ILE A 1 70  ? 21.507  -7.144  -5.367  1.00 8.08  ? 70  ILE A N   1 
ATOM   367  C CA  . ILE A 1 70  ? 21.157  -5.813  -5.809  1.00 8.46  ? 70  ILE A CA  1 
ATOM   368  C C   . ILE A 1 70  ? 22.322  -5.194  -6.578  1.00 9.01  ? 70  ILE A C   1 
ATOM   369  O O   . ILE A 1 70  ? 23.418  -4.989  -6.031  1.00 9.36  ? 70  ILE A O   1 
ATOM   370  C CB  . ILE A 1 70  ? 20.726  -4.912  -4.631  1.00 8.49  ? 70  ILE A CB  1 
ATOM   371  C CG1 . ILE A 1 70  ? 19.573  -5.516  -3.821  1.00 9.67  ? 70  ILE A CG1 1 
ATOM   372  C CG2 . ILE A 1 70  ? 20.433  -3.511  -5.141  1.00 7.93  ? 70  ILE A CG2 1 
ATOM   373  C CD1 . ILE A 1 70  ? 19.196  -4.729  -2.548  1.00 10.74 ? 70  ILE A CD1 1 
ATOM   374  N N   . PHE A 1 71  ? 22.026  -4.824  -7.842  1.00 8.33  ? 71  PHE A N   1 
ATOM   375  C CA  . PHE A 1 71  ? 22.900  -3.936  -8.588  1.00 8.71  ? 71  PHE A CA  1 
ATOM   376  C C   . PHE A 1 71  ? 22.521  -2.479  -8.304  1.00 8.65  ? 71  PHE A C   1 
ATOM   377  O O   . PHE A 1 71  ? 21.349  -2.140  -8.396  1.00 8.93  ? 71  PHE A O   1 
ATOM   378  C CB  . PHE A 1 71  ? 22.788  -4.203  -10.093 1.00 8.31  ? 71  PHE A CB  1 
ATOM   379  C CG  . PHE A 1 71  ? 23.334  -5.525  -10.567 1.00 9.18  ? 71  PHE A CG  1 
ATOM   380  C CD1 . PHE A 1 71  ? 24.672  -5.685  -10.862 1.00 9.79  ? 71  PHE A CD1 1 
ATOM   381  C CD2 . PHE A 1 71  ? 22.488  -6.587  -10.830 1.00 9.50  ? 71  PHE A CD2 1 
ATOM   382  C CE1 . PHE A 1 71  ? 25.178  -6.889  -11.339 1.00 9.46  ? 71  PHE A CE1 1 
ATOM   383  C CE2 . PHE A 1 71  ? 22.994  -7.802  -11.275 1.00 10.48 ? 71  PHE A CE2 1 
ATOM   384  C CZ  . PHE A 1 71  ? 24.335  -7.940  -11.554 1.00 10.11 ? 71  PHE A CZ  1 
ATOM   385  N N   . SER A 1 72  ? 23.519  -1.622  -8.055  1.00 8.09  ? 72  SER A N   1 
ATOM   386  C CA  . SER A 1 72  ? 23.280  -0.213  -7.824  1.00 8.12  ? 72  SER A CA  1 
ATOM   387  C C   . SER A 1 72  ? 24.201  0.601   -8.718  1.00 8.35  ? 72  SER A C   1 
ATOM   388  O O   . SER A 1 72  ? 25.414  0.572   -8.537  1.00 9.09  ? 72  SER A O   1 
ATOM   389  C CB  . SER A 1 72  ? 23.446  0.080   -6.335  1.00 8.27  ? 72  SER A CB  1 
ATOM   390  O OG  . SER A 1 72  ? 23.339  1.448   -6.005  1.00 7.75  ? 72  SER A OG  1 
ATOM   391  N N   . PHE A 1 73  ? 23.610  1.337   -9.667  1.00 8.64  ? 73  PHE A N   1 
ATOM   392  C CA  . PHE A 1 73  ? 24.352  1.992   -10.741 1.00 8.60  ? 73  PHE A CA  1 
ATOM   393  C C   . PHE A 1 73  ? 24.520  3.484   -10.453 1.00 8.59  ? 73  PHE A C   1 
ATOM   394  O O   . PHE A 1 73  ? 23.541  4.183   -10.180 1.00 9.24  ? 73  PHE A O   1 
ATOM   395  C CB  . PHE A 1 73  ? 23.631  1.786   -12.073 1.00 8.10  ? 73  PHE A CB  1 
ATOM   396  C CG  . PHE A 1 73  ? 23.560  0.353   -12.524 1.00 7.82  ? 73  PHE A CG  1 
ATOM   397  C CD1 . PHE A 1 73  ? 24.627  -0.222  -13.200 1.00 7.53  ? 73  PHE A CD1 1 
ATOM   398  C CD2 . PHE A 1 73  ? 22.447  -0.412  -12.274 1.00 7.57  ? 73  PHE A CD2 1 
ATOM   399  C CE1 . PHE A 1 73  ? 24.562  -1.533  -13.625 1.00 7.79  ? 73  PHE A CE1 1 
ATOM   400  C CE2 . PHE A 1 73  ? 22.393  -1.738  -12.693 1.00 7.83  ? 73  PHE A CE2 1 
ATOM   401  C CZ  . PHE A 1 73  ? 23.462  -2.300  -13.349 1.00 7.59  ? 73  PHE A CZ  1 
ATOM   402  N N   . HIS A 1 74  ? 25.771  3.964   -10.549 1.00 8.46  ? 74  HIS A N   1 
ATOM   403  C CA  . HIS A 1 74  ? 26.095  5.337   -10.206 1.00 7.91  ? 74  HIS A CA  1 
ATOM   404  C C   . HIS A 1 74  ? 25.541  6.314   -11.246 1.00 8.25  ? 74  HIS A C   1 
ATOM   405  O O   . HIS A 1 74  ? 25.244  5.949   -12.382 1.00 8.18  ? 74  HIS A O   1 
ATOM   406  C CB  . HIS A 1 74  ? 27.620  5.500   -10.021 1.00 7.94  ? 74  HIS A CB  1 
ATOM   407  C CG  . HIS A 1 74  ? 28.446  5.217   -11.252 1.00 7.85  ? 74  HIS A CG  1 
ATOM   408  N ND1 . HIS A 1 74  ? 28.479  6.046   -12.357 1.00 7.41  ? 74  HIS A ND1 1 
ATOM   409  C CD2 . HIS A 1 74  ? 29.240  4.168   -11.539 1.00 7.95  ? 74  HIS A CD2 1 
ATOM   410  C CE1 . HIS A 1 74  ? 29.253  5.487   -13.293 1.00 7.90  ? 74  HIS A CE1 1 
ATOM   411  N NE2 . HIS A 1 74  ? 29.751  4.356   -12.813 1.00 8.11  ? 74  HIS A NE2 1 
ATOM   412  N N   . GLY A 1 75  ? 25.515  7.586   -10.844 1.00 8.50  ? 75  GLY A N   1 
ATOM   413  C CA  . GLY A 1 75  ? 25.202  8.706   -11.702 1.00 8.77  ? 75  GLY A CA  1 
ATOM   414  C C   . GLY A 1 75  ? 26.380  9.112   -12.592 1.00 9.18  ? 75  GLY A C   1 
ATOM   415  O O   . GLY A 1 75  ? 27.505  8.670   -12.380 1.00 8.88  ? 75  GLY A O   1 
ATOM   416  N N   . ARG A 1 76  ? 26.068  9.877   -13.645 1.00 9.42  ? 76  ARG A N   1 
ATOM   417  C CA  . ARG A 1 76  ? 27.080  10.345  -14.583 1.00 9.87  ? 76  ARG A CA  1 
ATOM   418  C C   . ARG A 1 76  ? 28.152  11.166  -13.870 1.00 10.26 ? 76  ARG A C   1 
ATOM   419  O O   . ARG A 1 76  ? 27.837  12.037  -13.054 1.00 9.37  ? 76  ARG A O   1 
ATOM   420  C CB  . ARG A 1 76  ? 26.491  11.162  -15.728 1.00 10.87 ? 76  ARG A CB  1 
ATOM   421  C CG  . ARG A 1 76  ? 27.477  11.339  -16.879 1.00 11.76 ? 76  ARG A CG  1 
ATOM   422  C CD  . ARG A 1 76  ? 26.816  11.758  -18.157 1.00 12.66 ? 76  ARG A CD  1 
ATOM   423  N NE  . ARG A 1 76  ? 27.806  11.775  -19.218 1.00 13.34 ? 76  ARG A NE  1 
ATOM   424  C CZ  . ARG A 1 76  ? 28.359  12.881  -19.713 1.00 14.01 ? 76  ARG A CZ  1 
ATOM   425  N NH1 . ARG A 1 76  ? 28.035  14.078  -19.228 1.00 15.15 ? 76  ARG A NH1 1 
ATOM   426  N NH2 . ARG A 1 76  ? 29.240  12.771  -20.689 1.00 13.77 ? 76  ARG A NH2 1 
ATOM   427  N N   . GLY A 1 77  ? 29.419  10.825  -14.171 1.00 9.93  ? 77  GLY A N   1 
ATOM   428  C CA  . GLY A 1 77  ? 30.581  11.439  -13.556 1.00 10.68 ? 77  GLY A CA  1 
ATOM   429  C C   . GLY A 1 77  ? 30.910  10.885  -12.174 1.00 10.41 ? 77  GLY A C   1 
ATOM   430  O O   . GLY A 1 77  ? 31.844  11.375  -11.543 1.00 10.31 ? 77  GLY A O   1 
ATOM   431  N N   . LYS A 1 78  ? 30.161  9.867   -11.689 1.00 10.32 ? 78  LYS A N   1 
ATOM   432  C CA  . LYS A 1 78  ? 30.400  9.276   -10.378 1.00 10.68 ? 78  LYS A CA  1 
ATOM   433  C C   . LYS A 1 78  ? 31.064  7.913   -10.541 1.00 9.88  ? 78  LYS A C   1 
ATOM   434  O O   . LYS A 1 78  ? 31.411  7.503   -11.650 1.00 9.82  ? 78  LYS A O   1 
ATOM   435  C CB  . LYS A 1 78  ? 29.086  9.223   -9.581  1.00 11.46 ? 78  LYS A CB  1 
ATOM   436  C CG  . LYS A 1 78  ? 28.314  10.547  -9.530  1.00 12.30 ? 78  LYS A CG  1 
ATOM   437  C CD  . LYS A 1 78  ? 29.075  11.688  -8.889  1.00 13.40 ? 78  LYS A CD  1 
ATOM   438  C CE  . LYS A 1 78  ? 28.295  12.998  -8.787  1.00 14.60 ? 78  LYS A CE  1 
ATOM   439  N NZ  . LYS A 1 78  ? 27.811  13.464  -10.108 1.00 13.95 ? 78  LYS A NZ  1 
ATOM   440  N N   . THR A 1 79  ? 31.219  7.203   -9.426  1.00 11.45 ? 79  THR A N   1 
ATOM   441  C CA  . THR A 1 79  ? 31.984  5.965   -9.378  1.00 12.19 ? 79  THR A CA  1 
ATOM   442  C C   . THR A 1 79  ? 31.213  4.934   -8.571  1.00 12.03 ? 79  THR A C   1 
ATOM   443  O O   . THR A 1 79  ? 30.284  5.269   -7.836  1.00 10.99 ? 79  THR A O   1 
ATOM   444  C CB  . THR A 1 79  ? 33.379  6.121   -8.739  1.00 12.73 ? 79  THR A CB  1 
ATOM   445  O OG1 . THR A 1 79  ? 33.232  6.527   -7.371  1.00 11.64 ? 79  THR A OG1 1 
ATOM   446  C CG2 . THR A 1 79  ? 34.279  7.082   -9.480  1.00 14.45 ? 79  THR A CG2 1 
ATOM   447  N N   . ALA A 1 80  ? 31.641  3.681   -8.714  1.00 11.27 ? 80  ALA A N   1 
ATOM   448  C CA  . ALA A 1 80  ? 31.125  2.608   -7.884  1.00 11.04 ? 80  ALA A CA  1 
ATOM   449  C C   . ALA A 1 80  ? 31.241  2.954   -6.398  1.00 11.25 ? 80  ALA A C   1 
ATOM   450  O O   . ALA A 1 80  ? 30.314  2.728   -5.616  1.00 10.07 ? 80  ALA A O   1 
ATOM   451  C CB  . ALA A 1 80  ? 31.922  1.378   -8.207  1.00 11.47 ? 80  ALA A CB  1 
ATOM   452  N N   . GLU A 1 81  ? 32.420  3.466   -5.980  1.00 11.45 ? 81  GLU A N   1 
ATOM   453  C CA  . GLU A 1 81  ? 32.647  3.711   -4.559  1.00 13.43 ? 81  GLU A CA  1 
ATOM   454  C C   . GLU A 1 81  ? 31.714  4.823   -4.069  1.00 12.53 ? 81  GLU A C   1 
ATOM   455  O O   . GLU A 1 81  ? 31.124  4.695   -2.991  1.00 11.52 ? 81  GLU A O   1 
ATOM   456  C CB  . GLU A 1 81  ? 34.136  3.939   -4.248  1.00 17.68 ? 81  GLU A CB  1 
ATOM   457  C CG  . GLU A 1 81  ? 34.712  5.291   -4.662  1.00 22.08 ? 81  GLU A CG  1 
ATOM   458  C CD  . GLU A 1 81  ? 34.363  6.445   -3.725  1.00 29.94 ? 81  GLU A CD  1 
ATOM   459  O OE1 . GLU A 1 81  ? 34.403  7.633   -4.177  1.00 32.87 ? 81  GLU A OE1 1 
ATOM   460  O OE2 . GLU A 1 81  ? 34.049  6.152   -2.535  1.00 34.75 ? 81  GLU A OE2 1 
ATOM   461  N N   . SER A 1 82  ? 31.563  5.893   -4.856  1.00 11.21 ? 82  SER A N   1 
ATOM   462  C CA  . SER A 1 82  ? 30.706  6.988   -4.437  1.00 11.51 ? 82  SER A CA  1 
ATOM   463  C C   . SER A 1 82  ? 29.237  6.529   -4.377  1.00 10.89 ? 82  SER A C   1 
ATOM   464  O O   . SER A 1 82  ? 28.507  6.951   -3.479  1.00 9.62  ? 82  SER A O   1 
ATOM   465  C CB  . SER A 1 82  ? 30.900  8.231   -5.291  1.00 12.14 ? 82  SER A CB  1 
ATOM   466  O OG  . SER A 1 82  ? 30.326  8.111   -6.589  1.00 13.01 ? 82  SER A OG  1 
ATOM   467  N N   . GLN A 1 83  ? 28.811  5.667   -5.330  1.00 9.47  ? 83  GLN A N   1 
ATOM   468  C CA  . GLN A 1 83  ? 27.441  5.164   -5.375  1.00 9.71  ? 83  GLN A CA  1 
ATOM   469  C C   . GLN A 1 83  ? 27.131  4.252   -4.188  1.00 9.41  ? 83  GLN A C   1 
ATOM   470  O O   . GLN A 1 83  ? 26.025  4.340   -3.636  1.00 9.57  ? 83  GLN A O   1 
ATOM   471  C CB  . GLN A 1 83  ? 27.164  4.474   -6.715  1.00 9.78  ? 83  GLN A CB  1 
ATOM   472  C CG  . GLN A 1 83  ? 25.764  3.862   -6.840  1.00 9.60  ? 83  GLN A CG  1 
ATOM   473  C CD  . GLN A 1 83  ? 24.604  4.838   -6.750  1.00 10.16 ? 83  GLN A CD  1 
ATOM   474  O OE1 . GLN A 1 83  ? 24.759  6.062   -6.868  1.00 10.31 ? 83  GLN A OE1 1 
ATOM   475  N NE2 . GLN A 1 83  ? 23.392  4.283   -6.665  1.00 9.95  ? 83  GLN A NE2 1 
ATOM   476  N N   . GLU A 1 84  ? 28.119  3.481   -3.720  1.00 10.03 ? 84  GLU A N   1 
ATOM   477  C CA  . GLU A 1 84  ? 27.944  2.665   -2.523  1.00 10.56 ? 84  GLU A CA  1 
ATOM   478  C C   . GLU A 1 84  ? 27.666  3.584   -1.323  1.00 11.03 ? 84  GLU A C   1 
ATOM   479  O O   . GLU A 1 84  ? 26.781  3.283   -0.523  1.00 10.60 ? 84  GLU A O   1 
ATOM   480  C CB  . GLU A 1 84  ? 29.149  1.743   -2.290  1.00 10.80 ? 84  GLU A CB  1 
ATOM   481  C CG  . GLU A 1 84  ? 29.183  1.068   -0.920  1.00 10.95 ? 84  GLU A CG  1 
ATOM   482  C CD  . GLU A 1 84  ? 30.292  0.039   -0.767  1.00 12.63 ? 84  GLU A CD  1 
ATOM   483  O OE1 . GLU A 1 84  ? 31.422  0.319   -1.284  1.00 13.96 ? 84  GLU A OE1 1 
ATOM   484  O OE2 . GLU A 1 84  ? 30.051  -0.997  -0.104  1.00 12.96 ? 84  GLU A OE2 1 
ATOM   485  N N   . LYS A 1 85  ? 28.397  4.696   -1.201  1.00 12.19 ? 85  LYS A N   1 
ATOM   486  C CA  . LYS A 1 85  ? 28.160  5.611   -0.086  1.00 13.44 ? 85  LYS A CA  1 
ATOM   487  C C   . LYS A 1 85  ? 26.793  6.272   -0.187  1.00 11.59 ? 85  LYS A C   1 
ATOM   488  O O   . LYS A 1 85  ? 26.111  6.449   0.824   1.00 10.40 ? 85  LYS A O   1 
ATOM   489  C CB  . LYS A 1 85  ? 29.241  6.692   -0.022  1.00 15.34 ? 85  LYS A CB  1 
ATOM   490  C CG  . LYS A 1 85  ? 30.626  6.143   0.303   1.00 18.04 ? 85  LYS A CG  1 
ATOM   491  C CD  . LYS A 1 85  ? 31.720  7.199   0.126   1.00 20.98 ? 85  LYS A CD  1 
ATOM   492  C CE  . LYS A 1 85  ? 33.086  6.749   0.605   1.00 22.69 ? 85  LYS A CE  1 
ATOM   493  N NZ  . LYS A 1 85  ? 34.118  7.609   -0.017  1.00 24.78 ? 85  LYS A NZ  1 
ATOM   494  N N   . LEU A 1 86  ? 26.416  6.641   -1.420  1.00 10.24 ? 86  LEU A N   1 
ATOM   495  C CA  . LEU A 1 86  ? 25.175  7.361   -1.647  1.00 10.77 ? 86  LEU A CA  1 
ATOM   496  C C   . LEU A 1 86  ? 23.969  6.460   -1.391  1.00 10.01 ? 86  LEU A C   1 
ATOM   497  O O   . LEU A 1 86  ? 23.034  6.893   -0.735  1.00 10.25 ? 86  LEU A O   1 
ATOM   498  C CB  . LEU A 1 86  ? 25.176  7.934   -3.062  1.00 10.51 ? 86  LEU A CB  1 
ATOM   499  C CG  . LEU A 1 86  ? 23.960  8.762   -3.467  1.00 10.42 ? 86  LEU A CG  1 
ATOM   500  C CD1 . LEU A 1 86  ? 23.968  10.089  -2.723  1.00 10.80 ? 86  LEU A CD1 1 
ATOM   501  C CD2 . LEU A 1 86  ? 23.964  9.000   -4.961  1.00 10.65 ? 86  LEU A CD2 1 
ATOM   502  N N   . SER A 1 87  ? 23.979  5.232   -1.928  1.00 9.47  ? 87  SER A N   1 
ATOM   503  C CA  . SER A 1 87  ? 22.781  4.406   -2.035  1.00 9.12  ? 87  SER A CA  1 
ATOM   504  C C   . SER A 1 87  ? 22.643  3.535   -0.790  1.00 9.44  ? 87  SER A C   1 
ATOM   505  O O   . SER A 1 87  ? 21.565  3.037   -0.478  1.00 9.32  ? 87  SER A O   1 
ATOM   506  C CB  . SER A 1 87  ? 22.795  3.582   -3.320  1.00 9.03  ? 87  SER A CB  1 
ATOM   507  O OG  . SER A 1 87  ? 23.881  2.628   -3.345  1.00 9.36  ? 87  SER A OG  1 
ATOM   508  N N   . GLN A 1 88  ? 23.745  3.374   -0.064  1.00 10.01 ? 88  GLN A N   1 
ATOM   509  C CA  . GLN A 1 88  ? 23.746  2.709   1.245   1.00 11.04 ? 88  GLN A CA  1 
ATOM   510  C C   . GLN A 1 88  ? 23.238  1.265   1.174   1.00 10.40 ? 88  GLN A C   1 
ATOM   511  O O   . GLN A 1 88  ? 22.818  0.712   2.203   1.00 10.11 ? 88  GLN A O   1 
ATOM   512  C CB  . GLN A 1 88  ? 22.922  3.514   2.268   1.00 11.47 ? 88  GLN A CB  1 
ATOM   513  C CG  . GLN A 1 88  ? 23.599  4.791   2.746   1.00 11.95 ? 88  GLN A CG  1 
ATOM   514  C CD  . GLN A 1 88  ? 24.766  4.491   3.654   1.00 13.25 ? 88  GLN A CD  1 
ATOM   515  O OE1 . GLN A 1 88  ? 24.634  3.787   4.651   1.00 13.44 ? 88  GLN A OE1 1 
ATOM   516  N NE2 . GLN A 1 88  ? 25.948  4.943   3.277   1.00 13.64 ? 88  GLN A NE2 1 
ATOM   517  N N   . PHE A 1 89  ? 23.399  0.559   0.034   1.00 9.87  ? 89  PHE A N   1 
ATOM   518  C CA  . PHE A 1 89  ? 22.951  -0.829  0.023   1.00 10.24 ? 89  PHE A CA  1 
ATOM   519  C C   . PHE A 1 89  ? 23.912  -1.778  0.750   1.00 10.92 ? 89  PHE A C   1 
ATOM   520  O O   . PHE A 1 89  ? 23.560  -2.930  0.950   1.00 10.83 ? 89  PHE A O   1 
ATOM   521  C CB  . PHE A 1 89  ? 22.728  -1.397  -1.383  1.00 10.72 ? 89  PHE A CB  1 
ATOM   522  C CG  . PHE A 1 89  ? 21.526  -0.820  -2.077  1.00 10.36 ? 89  PHE A CG  1 
ATOM   523  C CD1 . PHE A 1 89  ? 20.240  -1.139  -1.671  1.00 11.04 ? 89  PHE A CD1 1 
ATOM   524  C CD2 . PHE A 1 89  ? 21.682  0.119   -3.078  1.00 11.04 ? 89  PHE A CD2 1 
ATOM   525  C CE1 . PHE A 1 89  ? 19.138  -0.618  -2.326  1.00 10.52 ? 89  PHE A CE1 1 
ATOM   526  C CE2 . PHE A 1 89  ? 20.578  0.663   -3.724  1.00 10.61 ? 89  PHE A CE2 1 
ATOM   527  C CZ  . PHE A 1 89  ? 19.303  0.303   -3.337  1.00 11.80 ? 89  PHE A CZ  1 
ATOM   528  N N   . SER A 1 90  ? 25.102  -1.339  1.123   1.00 10.83 ? 90  SER A N   1 
ATOM   529  C CA  . SER A 1 90  ? 25.948  -2.165  1.962   1.00 11.27 ? 90  SER A CA  1 
ATOM   530  C C   . SER A 1 90  ? 25.637  -1.961  3.443   1.00 13.94 ? 90  SER A C   1 
ATOM   531  O O   . SER A 1 90  ? 26.203  -2.644  4.288   1.00 15.81 ? 90  SER A O   1 
ATOM   532  C CB  . SER A 1 90  ? 27.378  -1.891  1.672   1.00 11.22 ? 90  SER A CB  1 
ATOM   533  O OG  . SER A 1 90  ? 27.620  -2.081  0.288   1.00 10.43 ? 90  SER A OG  1 
ATOM   534  N N   . ASN A 1 91  ? 24.747  -1.034  3.772   1.00 15.33 ? 91  ASN A N   1 
ATOM   535  C CA  . ASN A 1 91  ? 24.358  -0.815  5.159   1.00 16.27 ? 91  ASN A CA  1 
ATOM   536  C C   . ASN A 1 91  ? 23.496  -1.977  5.633   1.00 15.78 ? 91  ASN A C   1 
ATOM   537  O O   . ASN A 1 91  ? 22.390  -2.159  5.148   1.00 16.30 ? 91  ASN A O   1 
ATOM   538  C CB  . ASN A 1 91  ? 23.670  0.541   5.295   1.00 16.92 ? 91  ASN A CB  1 
ATOM   539  C CG  . ASN A 1 91  ? 23.184  0.892   6.692   1.00 20.31 ? 91  ASN A CG  1 
ATOM   540  O OD1 . ASN A 1 91  ? 22.916  0.048   7.528   1.00 19.15 ? 91  ASN A OD1 1 
ATOM   541  N ND2 . ASN A 1 91  ? 22.903  2.161   6.904   1.00 27.92 ? 91  ASN A ND2 1 
ATOM   542  N N   . GLU A 1 92  ? 23.996  -2.766  6.580   1.00 16.17 ? 92  GLU A N   1 
ATOM   543  C CA  . GLU A 1 92  ? 23.309  -3.981  7.013   1.00 18.50 ? 92  GLU A CA  1 
ATOM   544  C C   . GLU A 1 92  ? 22.038  -3.704  7.829   1.00 17.61 ? 92  GLU A C   1 
ATOM   545  O O   . GLU A 1 92  ? 21.231  -4.606  8.003   1.00 17.74 ? 92  GLU A O   1 
ATOM   546  C CB  . GLU A 1 92  ? 24.231  -4.830  7.895   1.00 22.68 ? 92  GLU A CB  1 
ATOM   547  C CG  . GLU A 1 92  ? 25.561  -5.189  7.204   1.00 27.83 ? 92  GLU A CG  1 
ATOM   548  C CD  . GLU A 1 92  ? 25.809  -6.660  6.925   1.00 26.79 ? 92  GLU A CD  1 
ATOM   549  O OE1 . GLU A 1 92  ? 25.069  -7.484  7.459   1.00 30.42 ? 92  GLU A OE1 1 
ATOM   550  O OE2 . GLU A 1 92  ? 26.753  -6.977  6.180   1.00 23.06 ? 92  GLU A OE2 1 
ATOM   551  N N   . ASP A 1 93  ? 21.877  -2.509  8.404   1.00 17.14 ? 93  ASP A N   1 
ATOM   552  C CA  . ASP A 1 93  ? 20.607  -2.128  9.020   1.00 17.28 ? 93  ASP A CA  1 
ATOM   553  C C   . ASP A 1 93  ? 19.500  -1.997  7.965   1.00 16.69 ? 93  ASP A C   1 
ATOM   554  O O   . ASP A 1 93  ? 18.365  -2.343  8.240   1.00 17.95 ? 93  ASP A O   1 
ATOM   555  C CB  . ASP A 1 93  ? 20.731  -0.841  9.832   1.00 20.57 ? 93  ASP A CB  1 
ATOM   556  C CG  . ASP A 1 93  ? 21.733  -0.988  10.971  1.00 25.24 ? 93  ASP A CG  1 
ATOM   557  O OD1 . ASP A 1 93  ? 21.945  -2.119  11.417  1.00 25.85 ? 93  ASP A OD1 1 
ATOM   558  O OD2 . ASP A 1 93  ? 22.333  0.012   11.360  1.00 32.86 ? 93  ASP A OD2 1 
ATOM   559  N N   . TRP A 1 94  ? 19.822  -1.502  6.758   1.00 13.88 ? 94  TRP A N   1 
ATOM   560  C CA  . TRP A 1 94  ? 18.823  -1.291  5.718   1.00 12.75 ? 94  TRP A CA  1 
ATOM   561  C C   . TRP A 1 94  ? 18.722  -2.491  4.767   1.00 13.08 ? 94  TRP A C   1 
ATOM   562  O O   . TRP A 1 94  ? 17.669  -2.770  4.209   1.00 13.76 ? 94  TRP A O   1 
ATOM   563  C CB  . TRP A 1 94  ? 19.192  -0.014  4.964   1.00 12.06 ? 94  TRP A CB  1 
ATOM   564  C CG  . TRP A 1 94  ? 18.933  1.244   5.749   1.00 12.61 ? 94  TRP A CG  1 
ATOM   565  C CD1 . TRP A 1 94  ? 18.273  1.376   6.933   1.00 14.13 ? 94  TRP A CD1 1 
ATOM   566  C CD2 . TRP A 1 94  ? 19.186  2.576   5.290   1.00 12.06 ? 94  TRP A CD2 1 
ATOM   567  N NE1 . TRP A 1 94  ? 18.118  2.699   7.254   1.00 13.89 ? 94  TRP A NE1 1 
ATOM   568  C CE2 . TRP A 1 94  ? 18.665  3.460   6.261   1.00 13.36 ? 94  TRP A CE2 1 
ATOM   569  C CE3 . TRP A 1 94  ? 19.790  3.110   4.147   1.00 11.71 ? 94  TRP A CE3 1 
ATOM   570  C CZ2 . TRP A 1 94  ? 18.749  4.849   6.119   1.00 13.19 ? 94  TRP A CZ2 1 
ATOM   571  C CZ3 . TRP A 1 94  ? 19.836  4.481   3.988   1.00 11.71 ? 94  TRP A CZ3 1 
ATOM   572  C CH2 . TRP A 1 94  ? 19.304  5.342   4.950   1.00 11.79 ? 94  TRP A CH2 1 
ATOM   573  N N   . ASN A 1 95  ? 19.847  -3.163  4.534   1.00 13.28 ? 95  ASN A N   1 
ATOM   574  C CA  . ASN A 1 95  ? 19.919  -4.304  3.623   1.00 13.44 ? 95  ASN A CA  1 
ATOM   575  C C   . ASN A 1 95  ? 20.659  -5.438  4.328   1.00 13.16 ? 95  ASN A C   1 
ATOM   576  O O   . ASN A 1 95  ? 21.847  -5.625  4.126   1.00 12.16 ? 95  ASN A O   1 
ATOM   577  C CB  . ASN A 1 95  ? 20.616  -3.950  2.307   1.00 13.15 ? 95  ASN A CB  1 
ATOM   578  C CG  . ASN A 1 95  ? 20.884  -5.197  1.486   1.00 13.89 ? 95  ASN A CG  1 
ATOM   579  O OD1 . ASN A 1 95  ? 20.095  -6.152  1.548   1.00 13.77 ? 95  ASN A OD1 1 
ATOM   580  N ND2 . ASN A 1 95  ? 22.030  -5.239  0.820   1.00 13.10 ? 95  ASN A ND2 1 
ATOM   581  N N   . PRO A 1 96  ? 20.019  -6.210  5.232   1.00 12.83 ? 96  PRO A N   1 
ATOM   582  C CA  . PRO A 1 96  ? 20.706  -7.343  5.871   1.00 13.66 ? 96  PRO A CA  1 
ATOM   583  C C   . PRO A 1 96  ? 21.030  -8.554  4.974   1.00 13.30 ? 96  PRO A C   1 
ATOM   584  O O   . PRO A 1 96  ? 21.948  -9.319  5.274   1.00 13.85 ? 96  PRO A O   1 
ATOM   585  C CB  . PRO A 1 96  ? 19.707  -7.750  6.959   1.00 13.24 ? 96  PRO A CB  1 
ATOM   586  C CG  . PRO A 1 96  ? 18.377  -7.287  6.462   1.00 13.52 ? 96  PRO A CG  1 
ATOM   587  C CD  . PRO A 1 96  ? 18.656  -5.978  5.751   1.00 13.78 ? 96  PRO A CD  1 
ATOM   588  N N   . ASP A 1 97  ? 20.270  -8.746  3.888   1.00 13.02 ? 97  ASP A N   1 
ATOM   589  C CA  . ASP A 1 97  ? 20.211  -10.056 3.244   1.00 13.18 ? 97  ASP A CA  1 
ATOM   590  C C   . ASP A 1 97  ? 20.866  -10.108 1.866   1.00 13.76 ? 97  ASP A C   1 
ATOM   591  O O   . ASP A 1 97  ? 21.349  -11.181 1.503   1.00 13.47 ? 97  ASP A O   1 
ATOM   592  C CB  . ASP A 1 97  ? 18.776  -10.566 3.112   1.00 14.91 ? 97  ASP A CB  1 
ATOM   593  C CG  . ASP A 1 97  ? 18.122  -10.770 4.470   1.00 17.62 ? 97  ASP A CG  1 
ATOM   594  O OD1 . ASP A 1 97  ? 18.837  -11.148 5.365   1.00 16.93 ? 97  ASP A OD1 1 
ATOM   595  O OD2 . ASP A 1 97  ? 16.920  -10.558 4.582   1.00 23.46 ? 97  ASP A OD2 1 
ATOM   596  N N   . ALA A 1 98  ? 20.906  -8.997  1.110   1.00 12.29 ? 98  ALA A N   1 
ATOM   597  C CA  . ALA A 1 98  ? 21.331  -9.083  -0.291  1.00 10.92 ? 98  ALA A CA  1 
ATOM   598  C C   . ALA A 1 98  ? 22.805  -8.769  -0.465  1.00 10.20 ? 98  ALA A C   1 
ATOM   599  O O   . ALA A 1 98  ? 23.347  -7.852  0.159   1.00 10.50 ? 98  ALA A O   1 
ATOM   600  C CB  . ALA A 1 98  ? 20.519  -8.140  -1.119  1.00 10.81 ? 98  ALA A CB  1 
ATOM   601  N N   . ILE A 1 99  ? 23.434  -9.469  -1.408  1.00 9.37  ? 99  ILE A N   1 
ATOM   602  C CA  . ILE A 1 99  ? 24.716  -9.033  -1.951  1.00 8.97  ? 99  ILE A CA  1 
ATOM   603  C C   . ILE A 1 99  ? 24.473  -7.716  -2.676  1.00 8.48  ? 99  ILE A C   1 
ATOM   604  O O   . ILE A 1 99  ? 23.450  -7.578  -3.356  1.00 10.04 ? 99  ILE A O   1 
ATOM   605  C CB  . ILE A 1 99  ? 25.317  -10.127 -2.863  1.00 9.61  ? 99  ILE A CB  1 
ATOM   606  C CG1 . ILE A 1 99  ? 25.724  -11.362 -2.043  1.00 9.98  ? 99  ILE A CG1 1 
ATOM   607  C CG2 . ILE A 1 99  ? 26.480  -9.566  -3.687  1.00 10.20 ? 99  ILE A CG2 1 
ATOM   608  C CD1 . ILE A 1 99  ? 25.744  -12.652 -2.844  1.00 10.81 ? 99  ILE A CD1 1 
ATOM   609  N N   . ALA A 1 100 ? 25.371  -6.742  -2.490  1.00 8.54  ? 100 ALA A N   1 
ATOM   610  C CA  . ALA A 1 100 ? 25.297  -5.485  -3.219  1.00 8.76  ? 100 ALA A CA  1 
ATOM   611  C C   . ALA A 1 100 ? 26.497  -5.341  -4.152  1.00 9.00  ? 100 ALA A C   1 
ATOM   612  O O   . ALA A 1 100 ? 27.654  -5.447  -3.745  1.00 10.05 ? 100 ALA A O   1 
ATOM   613  C CB  . ALA A 1 100 ? 25.182  -4.326  -2.264  1.00 9.08  ? 100 ALA A CB  1 
ATOM   614  N N   . VAL A 1 101 ? 26.190  -5.077  -5.414  1.00 8.66  ? 101 VAL A N   1 
ATOM   615  C CA  . VAL A 1 101 ? 27.176  -4.901  -6.459  1.00 8.95  ? 101 VAL A CA  1 
ATOM   616  C C   . VAL A 1 101 ? 27.044  -3.492  -7.026  1.00 8.99  ? 101 VAL A C   1 
ATOM   617  O O   . VAL A 1 101 ? 25.935  -3.081  -7.423  1.00 8.76  ? 101 VAL A O   1 
ATOM   618  C CB  . VAL A 1 101 ? 26.962  -5.956  -7.552  1.00 9.14  ? 101 VAL A CB  1 
ATOM   619  C CG1 . VAL A 1 101 ? 27.951  -5.815  -8.713  1.00 8.73  ? 101 VAL A CG1 1 
ATOM   620  C CG2 . VAL A 1 101 ? 27.018  -7.341  -6.958  1.00 9.57  ? 101 VAL A CG2 1 
ATOM   621  N N   . TYR A 1 102 ? 28.187  -2.802  -7.066  1.00 8.36  ? 102 TYR A N   1 
ATOM   622  C CA  . TYR A 1 102 ? 28.330  -1.440  -7.579  1.00 8.98  ? 102 TYR A CA  1 
ATOM   623  C C   . TYR A 1 102 ? 29.222  -1.474  -8.818  1.00 8.50  ? 102 TYR A C   1 
ATOM   624  O O   . TYR A 1 102 ? 30.441  -1.407  -8.749  1.00 8.82  ? 102 TYR A O   1 
ATOM   625  C CB  . TYR A 1 102 ? 28.889  -0.498  -6.501  1.00 8.82  ? 102 TYR A CB  1 
ATOM   626  C CG  . TYR A 1 102 ? 28.128  -0.599  -5.178  1.00 9.14  ? 102 TYR A CG  1 
ATOM   627  C CD1 . TYR A 1 102 ? 26.990  0.153   -4.933  1.00 9.48  ? 102 TYR A CD1 1 
ATOM   628  C CD2 . TYR A 1 102 ? 28.548  -1.476  -4.185  1.00 9.24  ? 102 TYR A CD2 1 
ATOM   629  C CE1 . TYR A 1 102 ? 26.275  0.014   -3.751  1.00 9.49  ? 102 TYR A CE1 1 
ATOM   630  C CE2 . TYR A 1 102 ? 27.844  -1.622  -2.997  1.00 9.04  ? 102 TYR A CE2 1 
ATOM   631  C CZ  . TYR A 1 102 ? 26.721  -0.845  -2.761  1.00 8.73  ? 102 TYR A CZ  1 
ATOM   632  O OH  . TYR A 1 102 ? 26.066  -0.964  -1.549  1.00 8.92  ? 102 TYR A OH  1 
ATOM   633  N N   . PRO A 1 103 ? 28.645  -1.583  -10.021 1.00 9.40  ? 103 PRO A N   1 
ATOM   634  C CA  . PRO A 1 103 ? 29.437  -1.625  -11.238 1.00 9.60  ? 103 PRO A CA  1 
ATOM   635  C C   . PRO A 1 103 ? 29.951  -0.251  -11.620 1.00 9.47  ? 103 PRO A C   1 
ATOM   636  O O   . PRO A 1 103 ? 29.316  0.759   -11.326 1.00 9.43  ? 103 PRO A O   1 
ATOM   637  C CB  . PRO A 1 103 ? 28.462  -2.151  -12.300 1.00 9.90  ? 103 PRO A CB  1 
ATOM   638  C CG  . PRO A 1 103 ? 27.277  -2.644  -11.504 1.00 10.20 ? 103 PRO A CG  1 
ATOM   639  C CD  . PRO A 1 103 ? 27.210  -1.737  -10.294 1.00 9.68  ? 103 PRO A CD  1 
ATOM   640  N N   . GLN A 1 104 ? 31.090  -0.244  -12.329 1.00 9.30  ? 104 GLN A N   1 
ATOM   641  C CA  . GLN A 1 104 ? 31.666  1.001   -12.800 1.00 9.07  ? 104 GLN A CA  1 
ATOM   642  C C   . GLN A 1 104 ? 31.369  1.200   -14.274 1.00 8.70  ? 104 GLN A C   1 
ATOM   643  O O   . GLN A 1 104 ? 31.630  0.326   -15.114 1.00 8.70  ? 104 GLN A O   1 
ATOM   644  C CB  . GLN A 1 104 ? 33.180  1.007   -12.607 1.00 9.13  ? 104 GLN A CB  1 
ATOM   645  C CG  . GLN A 1 104 ? 33.844  2.279   -13.096 1.00 9.37  ? 104 GLN A CG  1 
ATOM   646  C CD  . GLN A 1 104 ? 33.377  3.514   -12.361 1.00 9.70  ? 104 GLN A CD  1 
ATOM   647  O OE1 . GLN A 1 104 ? 33.405  3.563   -11.135 1.00 9.16  ? 104 GLN A OE1 1 
ATOM   648  N NE2 . GLN A 1 104 ? 32.973  4.529   -13.111 1.00 10.16 ? 104 GLN A NE2 1 
ATOM   649  N N   . GLY A 1 105 ? 30.880  2.388   -14.603 1.00 8.48  ? 105 GLY A N   1 
ATOM   650  C CA  . GLY A 1 105 ? 30.577  2.730   -15.986 1.00 8.50  ? 105 GLY A CA  1 
ATOM   651  C C   . GLY A 1 105 ? 31.850  3.217   -16.684 1.00 8.86  ? 105 GLY A C   1 
ATOM   652  O O   . GLY A 1 105 ? 32.676  3.903   -16.091 1.00 9.18  ? 105 GLY A O   1 
ATOM   653  N N   . LEU A 1 106 ? 32.046  2.835   -17.934 1.00 9.40  ? 106 LEU A N   1 
ATOM   654  C CA  . LEU A 1 106 ? 33.146  3.397   -18.714 1.00 10.32 ? 106 LEU A CA  1 
ATOM   655  C C   . LEU A 1 106 ? 32.942  4.905   -18.845 1.00 11.01 ? 106 LEU A C   1 
ATOM   656  O O   . LEU A 1 106 ? 31.824  5.362   -19.049 1.00 9.81  ? 106 LEU A O   1 
ATOM   657  C CB  . LEU A 1 106 ? 33.204  2.711   -20.082 1.00 11.00 ? 106 LEU A CB  1 
ATOM   658  C CG  . LEU A 1 106 ? 33.466  1.200   -20.035 1.00 12.37 ? 106 LEU A CG  1 
ATOM   659  C CD1 . LEU A 1 106 ? 33.654  0.622   -21.426 1.00 12.76 ? 106 LEU A CD1 1 
ATOM   660  C CD2 . LEU A 1 106 ? 34.673  0.888   -19.164 1.00 12.36 ? 106 LEU A CD2 1 
ATOM   661  N N   . ASN A 1 107 ? 34.034  5.671   -18.693 1.00 10.86 ? 107 ASN A N   1 
ATOM   662  C CA  . ASN A 1 107 ? 33.986  7.130   -18.754 1.00 12.52 ? 107 ASN A CA  1 
ATOM   663  C C   . ASN A 1 107 ? 33.000  7.698   -17.715 1.00 11.12 ? 107 ASN A C   1 
ATOM   664  O O   . ASN A 1 107 ? 32.376  8.719   -17.963 1.00 10.90 ? 107 ASN A O   1 
ATOM   665  C CB  . ASN A 1 107 ? 33.614  7.604   -20.169 1.00 13.11 ? 107 ASN A CB  1 
ATOM   666  C CG  . ASN A 1 107 ? 34.579  7.053   -21.196 1.00 17.59 ? 107 ASN A CG  1 
ATOM   667  O OD1 . ASN A 1 107 ? 35.785  7.279   -21.067 1.00 20.38 ? 107 ASN A OD1 1 
ATOM   668  N ND2 . ASN A 1 107 ? 34.099  6.184   -22.082 1.00 17.28 ? 107 ASN A ND2 1 
ATOM   669  N N   . LYS A 1 108 ? 32.792  6.966   -16.616 1.00 11.46 ? 108 LYS A N   1 
ATOM   670  C CA  . LYS A 1 108 ? 31.874  7.331   -15.549 1.00 11.34 ? 108 LYS A CA  1 
ATOM   671  C C   . LYS A 1 108 ? 30.465  7.626   -16.068 1.00 11.42 ? 108 LYS A C   1 
ATOM   672  O O   . LYS A 1 108 ? 29.805  8.548   -15.571 1.00 10.30 ? 108 LYS A O   1 
ATOM   673  C CB  . LYS A 1 108 ? 32.425  8.532   -14.779 1.00 12.92 ? 108 LYS A CB  1 
ATOM   674  C CG  . LYS A 1 108 ? 33.717  8.276   -14.015 1.00 16.07 ? 108 LYS A CG  1 
ATOM   675  C CD  . LYS A 1 108 ? 34.182  9.527   -13.317 1.00 17.74 ? 108 LYS A CD  1 
ATOM   676  C CE  . LYS A 1 108 ? 35.298  9.315   -12.325 1.00 21.98 ? 108 LYS A CE  1 
ATOM   677  N NZ  . LYS A 1 108 ? 36.511  8.865   -13.005 1.00 25.49 ? 108 LYS A NZ  1 
ATOM   678  N N   . GLU A 1 109 ? 29.990  6.810   -17.019 1.00 11.36 ? 109 GLU A N   1 
ATOM   679  C CA  . GLU A 1 109 ? 28.631  6.922   -17.549 1.00 10.91 ? 109 GLU A CA  1 
ATOM   680  C C   . GLU A 1 109 ? 28.151  5.546   -17.998 1.00 10.67 ? 109 GLU A C   1 
ATOM   681  O O   . GLU A 1 109 ? 28.901  4.565   -17.891 1.00 10.84 ? 109 GLU A O   1 
ATOM   682  C CB  . GLU A 1 109 ? 28.548  7.943   -18.687 1.00 11.86 ? 109 GLU A CB  1 
ATOM   683  C CG  . GLU A 1 109 ? 29.302  7.509   -19.938 1.00 12.73 ? 109 GLU A CG  1 
ATOM   684  C CD  . GLU A 1 109 ? 29.677  8.644   -20.885 1.00 14.80 ? 109 GLU A CD  1 
ATOM   685  O OE1 . GLU A 1 109 ? 29.383  9.798   -20.557 1.00 15.59 ? 109 GLU A OE1 1 
ATOM   686  O OE2 . GLU A 1 109 ? 30.301  8.370   -21.924 1.00 15.98 ? 109 GLU A OE2 1 
ATOM   687  N N   . TRP A 1 110 ? 26.884  5.488   -18.440 1.00 9.58  ? 110 TRP A N   1 
ATOM   688  C CA  . TRP A 1 110 ? 26.185  4.243   -18.758 1.00 9.30  ? 110 TRP A CA  1 
ATOM   689  C C   . TRP A 1 110 ? 25.487  4.386   -20.097 1.00 9.77  ? 110 TRP A C   1 
ATOM   690  O O   . TRP A 1 110 ? 25.055  5.481   -20.449 1.00 10.19 ? 110 TRP A O   1 
ATOM   691  C CB  . TRP A 1 110 ? 25.117  3.882   -17.701 1.00 8.74  ? 110 TRP A CB  1 
ATOM   692  C CG  . TRP A 1 110 ? 25.684  3.665   -16.338 1.00 8.15  ? 110 TRP A CG  1 
ATOM   693  C CD1 . TRP A 1 110 ? 25.625  4.507   -15.259 1.00 8.16  ? 110 TRP A CD1 1 
ATOM   694  C CD2 . TRP A 1 110 ? 26.455  2.526   -15.913 1.00 8.06  ? 110 TRP A CD2 1 
ATOM   695  N NE1 . TRP A 1 110 ? 26.308  3.966   -14.201 1.00 7.89  ? 110 TRP A NE1 1 
ATOM   696  C CE2 . TRP A 1 110 ? 26.838  2.763   -14.575 1.00 7.77  ? 110 TRP A CE2 1 
ATOM   697  C CE3 . TRP A 1 110 ? 26.881  1.359   -16.544 1.00 8.21  ? 110 TRP A CE3 1 
ATOM   698  C CZ2 . TRP A 1 110 ? 27.605  1.862   -13.855 1.00 7.90  ? 110 TRP A CZ2 1 
ATOM   699  C CZ3 . TRP A 1 110 ? 27.632  0.469   -15.825 1.00 8.61  ? 110 TRP A CZ3 1 
ATOM   700  C CH2 . TRP A 1 110 ? 28.010  0.720   -14.504 1.00 7.86  ? 110 TRP A CH2 1 
ATOM   701  N N   . GLN A 1 111 ? 25.373  3.251   -20.782 1.00 9.71  ? 111 GLN A N   1 
ATOM   702  C CA  . GLN A 1 111 ? 24.499  3.072   -21.914 1.00 10.13 ? 111 GLN A CA  1 
ATOM   703  C C   . GLN A 1 111 ? 23.217  3.856   -21.689 1.00 11.20 ? 111 GLN A C   1 
ATOM   704  O O   . GLN A 1 111 ? 22.596  3.763   -20.623 1.00 10.46 ? 111 GLN A O   1 
ATOM   705  C CB  . GLN A 1 111 ? 24.227  1.576   -22.067 1.00 10.75 ? 111 GLN A CB  1 
ATOM   706  C CG  . GLN A 1 111 ? 23.453  1.211   -23.309 1.00 11.43 ? 111 GLN A CG  1 
ATOM   707  C CD  . GLN A 1 111 ? 23.288  -0.282  -23.451 1.00 12.45 ? 111 GLN A CD  1 
ATOM   708  O OE1 . GLN A 1 111 ? 23.872  -1.104  -22.734 1.00 10.87 ? 111 GLN A OE1 1 
ATOM   709  N NE2 . GLN A 1 111 ? 22.386  -0.636  -24.347 1.00 14.83 ? 111 GLN A NE2 1 
ATOM   710  N N   . GLY A 1 112 ? 22.806  4.574   -22.740 1.00 11.06 ? 112 GLY A N   1 
ATOM   711  C CA  . GLY A 1 112 ? 21.611  5.403   -22.701 1.00 11.45 ? 112 GLY A CA  1 
ATOM   712  C C   . GLY A 1 112 ? 21.959  6.893   -22.643 1.00 11.25 ? 112 GLY A C   1 
ATOM   713  O O   . GLY A 1 112 ? 21.202  7.727   -23.141 1.00 13.53 ? 112 GLY A O   1 
ATOM   714  N N   . ASP A 1 113 ? 23.111  7.221   -22.056 1.00 10.56 ? 113 ASP A N   1 
ATOM   715  C CA  . ASP A 1 113 ? 23.567  8.599   -22.017 1.00 10.63 ? 113 ASP A CA  1 
ATOM   716  C C   . ASP A 1 113 ? 23.898  9.052   -23.441 1.00 11.36 ? 113 ASP A C   1 
ATOM   717  O O   . ASP A 1 113 ? 24.442  8.269   -24.202 1.00 9.60  ? 113 ASP A O   1 
ATOM   718  C CB  . ASP A 1 113 ? 24.804  8.761   -21.158 1.00 10.76 ? 113 ASP A CB  1 
ATOM   719  C CG  . ASP A 1 113 ? 25.132  10.224  -20.979 1.00 11.17 ? 113 ASP A CG  1 
ATOM   720  O OD1 . ASP A 1 113 ? 24.469  10.826  -20.147 1.00 10.68 ? 113 ASP A OD1 1 
ATOM   721  O OD2 . ASP A 1 113 ? 25.951  10.762  -21.773 1.00 11.69 ? 113 ASP A OD2 1 
ATOM   722  N N   . PRO A 1 114 ? 23.595  10.308  -23.850 1.00 12.45 ? 114 PRO A N   1 
ATOM   723  C CA  . PRO A 1 114 ? 23.963  10.796  -25.180 1.00 12.70 ? 114 PRO A CA  1 
ATOM   724  C C   . PRO A 1 114 ? 25.435  10.609  -25.546 1.00 13.17 ? 114 PRO A C   1 
ATOM   725  O O   . PRO A 1 114 ? 25.750  10.462  -26.709 1.00 13.64 ? 114 PRO A O   1 
ATOM   726  C CB  . PRO A 1 114 ? 23.648  12.295  -25.125 1.00 13.43 ? 114 PRO A CB  1 
ATOM   727  C CG  . PRO A 1 114 ? 22.541  12.405  -24.101 1.00 13.51 ? 114 PRO A CG  1 
ATOM   728  C CD  . PRO A 1 114 ? 22.821  11.309  -23.088 1.00 13.26 ? 114 PRO A CD  1 
ATOM   729  N N   . HIS A 1 115 ? 26.337  10.603  -24.555 1.00 13.90 ? 115 HIS A N   1 
ATOM   730  C CA  . HIS A 1 115 ? 27.753  10.420  -24.797 1.00 13.34 ? 115 HIS A CA  1 
ATOM   731  C C   . HIS A 1 115 ? 28.220  8.956   -24.867 1.00 13.50 ? 115 HIS A C   1 
ATOM   732  O O   . HIS A 1 115 ? 29.360  8.724   -25.261 1.00 12.33 ? 115 HIS A O   1 
ATOM   733  C CB  . HIS A 1 115 ? 28.529  11.192  -23.732 1.00 14.09 ? 115 HIS A CB  1 
ATOM   734  C CG  . HIS A 1 115 ? 29.975  11.300  -23.988 1.00 14.87 ? 115 HIS A CG  1 
ATOM   735  N ND1 . HIS A 1 115 ? 30.846  10.407  -23.392 1.00 16.30 ? 115 HIS A ND1 1 
ATOM   736  C CD2 . HIS A 1 115 ? 30.733  12.139  -24.741 1.00 17.34 ? 115 HIS A CD2 1 
ATOM   737  C CE1 . HIS A 1 115 ? 32.103  10.724  -23.739 1.00 18.67 ? 115 HIS A CE1 1 
ATOM   738  N NE2 . HIS A 1 115 ? 32.060  11.780  -24.540 1.00 18.98 ? 115 HIS A NE2 1 
ATOM   739  N N   . SER A 1 116 ? 27.399  7.978   -24.442 1.00 13.22 ? 116 SER A N   1 
ATOM   740  C CA  . SER A 1 116 ? 27.795  6.572   -24.403 1.00 13.45 ? 116 SER A CA  1 
ATOM   741  C C   . SER A 1 116 ? 27.565  5.954   -25.777 1.00 13.91 ? 116 SER A C   1 
ATOM   742  O O   . SER A 1 116 ? 26.430  5.873   -26.203 1.00 15.25 ? 116 SER A O   1 
ATOM   743  C CB  . SER A 1 116 ? 27.015  5.780   -23.339 1.00 14.23 ? 116 SER A CB  1 
ATOM   744  O OG  . SER A 1 116 ? 27.364  4.393   -23.318 1.00 12.93 ? 116 SER A OG  1 
ATOM   745  N N   . LYS A 1 117 ? 28.630  5.545   -26.455 1.00 14.99 ? 117 LYS A N   1 
ATOM   746  C CA  . LYS A 1 117 ? 28.503  4.997   -27.803 1.00 19.31 ? 117 LYS A CA  1 
ATOM   747  C C   . LYS A 1 117 ? 29.098  3.600   -27.836 1.00 15.84 ? 117 LYS A C   1 
ATOM   748  O O   . LYS A 1 117 ? 30.231  3.412   -27.443 1.00 15.66 ? 117 LYS A O   1 
ATOM   749  C CB  . LYS A 1 117 ? 29.195  5.900   -28.832 1.00 22.61 ? 117 LYS A CB  1 
ATOM   750  C CG  . LYS A 1 117 ? 29.126  5.464   -30.295 1.00 28.75 ? 117 LYS A CG  1 
ATOM   751  C CD  . LYS A 1 117 ? 27.819  5.785   -31.018 1.00 32.32 ? 117 LYS A CD  1 
ATOM   752  C CE  . LYS A 1 117 ? 27.998  6.015   -32.510 1.00 33.17 ? 117 LYS A CE  1 
ATOM   753  N NZ  . LYS A 1 117 ? 29.055  5.140   -33.059 1.00 37.76 ? 117 LYS A NZ  1 
ATOM   754  N N   . ASP A 1 118 ? 28.301  2.651   -28.308 1.00 16.93 ? 118 ASP A N   1 
ATOM   755  C CA  . ASP A 1 118 ? 28.721  1.285   -28.594 1.00 20.26 ? 118 ASP A CA  1 
ATOM   756  C C   . ASP A 1 118 ? 29.295  0.639   -27.338 1.00 18.24 ? 118 ASP A C   1 
ATOM   757  O O   . ASP A 1 118 ? 30.227  -0.142  -27.438 1.00 20.20 ? 118 ASP A O   1 
ATOM   758  C CB  . ASP A 1 118 ? 29.712  1.217   -29.767 1.00 24.80 ? 118 ASP A CB  1 
ATOM   759  C CG  . ASP A 1 118 ? 29.128  1.750   -31.072 1.00 27.64 ? 118 ASP A CG  1 
ATOM   760  O OD1 . ASP A 1 118 ? 27.936  1.558   -31.298 1.00 28.19 ? 118 ASP A OD1 1 
ATOM   761  O OD2 . ASP A 1 118 ? 29.881  2.346   -31.851 1.00 36.98 ? 118 ASP A OD2 1 
ATOM   762  N N   . VAL A 1 119 ? 28.750  0.976   -26.158 1.00 16.33 ? 119 VAL A N   1 
ATOM   763  C CA  . VAL A 1 119 ? 29.092  0.272   -24.935 1.00 13.83 ? 119 VAL A CA  1 
ATOM   764  C C   . VAL A 1 119 ? 27.857  -0.526  -24.529 1.00 13.27 ? 119 VAL A C   1 
ATOM   765  O O   . VAL A 1 119 ? 26.799  0.052   -24.239 1.00 12.33 ? 119 VAL A O   1 
ATOM   766  C CB  . VAL A 1 119 ? 29.557  1.220   -23.801 1.00 13.86 ? 119 VAL A CB  1 
ATOM   767  C CG1 . VAL A 1 119 ? 29.886  0.443   -22.523 1.00 14.18 ? 119 VAL A CG1 1 
ATOM   768  C CG2 . VAL A 1 119 ? 30.780  2.051   -24.206 1.00 14.67 ? 119 VAL A CG2 1 
ATOM   769  N N   . ASP A 1 120 ? 27.983  -1.856  -24.533 1.00 12.60 ? 120 ASP A N   1 
ATOM   770  C CA  . ASP A 1 120 ? 26.872  -2.729  -24.191 1.00 12.30 ? 120 ASP A CA  1 
ATOM   771  C C   . ASP A 1 120 ? 26.906  -3.038  -22.690 1.00 11.19 ? 120 ASP A C   1 
ATOM   772  O O   . ASP A 1 120 ? 27.483  -4.046  -22.255 1.00 11.12 ? 120 ASP A O   1 
ATOM   773  C CB  . ASP A 1 120 ? 26.838  -3.957  -25.100 1.00 13.29 ? 120 ASP A CB  1 
ATOM   774  C CG  . ASP A 1 120 ? 25.576  -4.773  -24.915 1.00 14.62 ? 120 ASP A CG  1 
ATOM   775  O OD1 . ASP A 1 120 ? 24.745  -4.421  -24.051 1.00 14.67 ? 120 ASP A OD1 1 
ATOM   776  O OD2 . ASP A 1 120 ? 25.392  -5.713  -25.680 1.00 15.18 ? 120 ASP A OD2 1 
ATOM   777  N N   . ASP A 1 121 ? 26.323  -2.122  -21.900 1.00 10.19 ? 121 ASP A N   1 
ATOM   778  C CA  . ASP A 1 121 ? 26.244  -2.285  -20.452 1.00 10.01 ? 121 ASP A CA  1 
ATOM   779  C C   . ASP A 1 121 ? 25.225  -3.349  -20.033 1.00 10.24 ? 121 ASP A C   1 
ATOM   780  O O   . ASP A 1 121 ? 25.320  -3.888  -18.930 1.00 9.90  ? 121 ASP A O   1 
ATOM   781  C CB  . ASP A 1 121 ? 26.032  -0.939  -19.772 1.00 9.47  ? 121 ASP A CB  1 
ATOM   782  C CG  . ASP A 1 121 ? 27.301  -0.094  -19.740 1.00 9.58  ? 121 ASP A CG  1 
ATOM   783  O OD1 . ASP A 1 121 ? 28.379  -0.622  -19.357 1.00 9.44  ? 121 ASP A OD1 1 
ATOM   784  O OD2 . ASP A 1 121 ? 27.193  1.088   -20.033 1.00 9.62  ? 121 ASP A OD2 1 
ATOM   785  N N   . ILE A 1 122 ? 24.228  -3.628  -20.871 1.00 9.69  ? 122 ILE A N   1 
ATOM   786  C CA  . ILE A 1 122 ? 23.337  -4.755  -20.636 1.00 10.07 ? 122 ILE A CA  1 
ATOM   787  C C   . ILE A 1 122 ? 24.109  -6.068  -20.659 1.00 9.90  ? 122 ILE A C   1 
ATOM   788  O O   . ILE A 1 122 ? 23.946  -6.879  -19.758 1.00 9.07  ? 122 ILE A O   1 
ATOM   789  C CB  . ILE A 1 122 ? 22.155  -4.750  -21.623 1.00 10.82 ? 122 ILE A CB  1 
ATOM   790  C CG1 . ILE A 1 122 ? 21.401  -3.425  -21.522 1.00 12.62 ? 122 ILE A CG1 1 
ATOM   791  C CG2 . ILE A 1 122 ? 21.259  -5.954  -21.362 1.00 10.13 ? 122 ILE A CG2 1 
ATOM   792  C CD1 . ILE A 1 122 ? 20.275  -3.254  -22.509 1.00 14.66 ? 122 ILE A CD1 1 
ATOM   793  N N   . ALA A 1 123 ? 24.983  -6.270  -21.658 1.00 10.96 ? 123 ALA A N   1 
ATOM   794  C CA  . ALA A 1 123 ? 25.836  -7.450  -21.680 1.00 11.11 ? 123 ALA A CA  1 
ATOM   795  C C   . ALA A 1 123 ? 26.722  -7.515  -20.435 1.00 10.19 ? 123 ALA A C   1 
ATOM   796  O O   . ALA A 1 123 ? 26.856  -8.575  -19.827 1.00 9.32  ? 123 ALA A O   1 
ATOM   797  C CB  . ALA A 1 123 ? 26.699  -7.455  -22.927 1.00 12.25 ? 123 ALA A CB  1 
ATOM   798  N N   . PHE A 1 124 ? 27.323  -6.378  -20.038 1.00 9.31  ? 124 PHE A N   1 
ATOM   799  C CA  . PHE A 1 124 ? 28.103  -6.329  -18.808 1.00 8.99  ? 124 PHE A CA  1 
ATOM   800  C C   . PHE A 1 124 ? 27.267  -6.826  -17.626 1.00 9.07  ? 124 PHE A C   1 
ATOM   801  O O   . PHE A 1 124 ? 27.720  -7.641  -16.826 1.00 9.61  ? 124 PHE A O   1 
ATOM   802  C CB  . PHE A 1 124 ? 28.588  -4.898  -18.583 1.00 8.63  ? 124 PHE A CB  1 
ATOM   803  C CG  . PHE A 1 124 ? 29.335  -4.579  -17.312 1.00 8.87  ? 124 PHE A CG  1 
ATOM   804  C CD1 . PHE A 1 124 ? 30.160  -5.499  -16.694 1.00 8.74  ? 124 PHE A CD1 1 
ATOM   805  C CD2 . PHE A 1 124 ? 29.278  -3.293  -16.790 1.00 8.81  ? 124 PHE A CD2 1 
ATOM   806  C CE1 . PHE A 1 124 ? 30.880  -5.157  -15.564 1.00 9.29  ? 124 PHE A CE1 1 
ATOM   807  C CE2 . PHE A 1 124 ? 29.996  -2.957  -15.655 1.00 8.72  ? 124 PHE A CE2 1 
ATOM   808  C CZ  . PHE A 1 124 ? 30.773  -3.897  -15.025 1.00 9.08  ? 124 PHE A CZ  1 
ATOM   809  N N   . THR A 1 125 ? 26.049  -6.323  -17.509 1.00 8.98  ? 125 THR A N   1 
ATOM   810  C CA  . THR A 1 125 ? 25.218  -6.690  -16.374 1.00 9.48  ? 125 THR A CA  1 
ATOM   811  C C   . THR A 1 125 ? 24.877  -8.187  -16.408 1.00 9.71  ? 125 THR A C   1 
ATOM   812  O O   . THR A 1 125 ? 24.934  -8.861  -15.364 1.00 10.12 ? 125 THR A O   1 
ATOM   813  C CB  . THR A 1 125 ? 23.967  -5.792  -16.325 1.00 9.95  ? 125 THR A CB  1 
ATOM   814  O OG1 . THR A 1 125 ? 24.333  -4.402  -16.283 1.00 9.74  ? 125 THR A OG1 1 
ATOM   815  C CG2 . THR A 1 125 ? 23.099  -6.094  -15.123 1.00 9.93  ? 125 THR A CG2 1 
ATOM   816  N N   . MET A 1 126 ? 24.468  -8.690  -17.585 1.00 10.35 ? 126 MET A N   1 
ATOM   817  C CA  . MET A 1 126 ? 24.089  -10.081 -17.762 1.00 10.77 ? 126 MET A CA  1 
ATOM   818  C C   . MET A 1 126 ? 25.294  -10.998 -17.481 1.00 10.66 ? 126 MET A C   1 
ATOM   819  O O   . MET A 1 126 ? 25.145  -11.992 -16.779 1.00 10.39 ? 126 MET A O   1 
ATOM   820  C CB  . MET A 1 126 ? 23.509  -10.323 -19.163 1.00 11.57 ? 126 MET A CB  1 
ATOM   821  C CG  . MET A 1 126 ? 22.128  -9.652  -19.386 1.00 13.10 ? 126 MET A CG  1 
ATOM   822  S SD  . MET A 1 126 ? 20.824  -10.062 -18.192 1.00 15.38 ? 126 MET A SD  1 
ATOM   823  C CE  . MET A 1 126 ? 20.962  -8.734  -16.997 1.00 16.89 ? 126 MET A CE  1 
ATOM   824  N N   . GLU A 1 127 ? 26.510  -10.643 -17.934 1.00 10.64 ? 127 GLU A N   1 
ATOM   825  C CA  . GLU A 1 127 ? 27.670  -11.500 -17.736 1.00 10.32 ? 127 GLU A CA  1 
ATOM   826  C C   . GLU A 1 127 ? 28.102  -11.455 -16.269 1.00 10.30 ? 127 GLU A C   1 
ATOM   827  O O   . GLU A 1 127 ? 28.500  -12.489 -15.707 1.00 10.31 ? 127 GLU A O   1 
ATOM   828  C CB  . GLU A 1 127 ? 28.819  -11.136 -18.682 1.00 11.28 ? 127 GLU A CB  1 
ATOM   829  C CG  . GLU A 1 127 ? 28.514  -11.375 -20.127 1.00 12.23 ? 127 GLU A CG  1 
ATOM   830  C CD  . GLU A 1 127 ? 29.689  -11.203 -21.089 1.00 13.05 ? 127 GLU A CD  1 
ATOM   831  O OE1 . GLU A 1 127 ? 30.776  -11.734 -20.802 1.00 12.30 ? 127 GLU A OE1 1 
ATOM   832  O OE2 . GLU A 1 127 ? 29.490  -10.559 -22.132 1.00 12.55 ? 127 GLU A OE2 1 
ATOM   833  N N   . MET A 1 128 ? 27.990  -10.275 -15.626 1.00 9.87  ? 128 MET A N   1 
ATOM   834  C CA  . MET A 1 128 ? 28.195  -10.152 -14.192 1.00 9.57  ? 128 MET A CA  1 
ATOM   835  C C   . MET A 1 128 ? 27.259  -11.110 -13.448 1.00 9.65  ? 128 MET A C   1 
ATOM   836  O O   . MET A 1 128 ? 27.694  -11.867 -12.582 1.00 9.95  ? 128 MET A O   1 
ATOM   837  C CB  . MET A 1 128 ? 27.943  -8.723  -13.697 1.00 10.10 ? 128 MET A CB  1 
ATOM   838  C CG  . MET A 1 128 ? 29.202  -7.870  -13.601 1.00 10.40 ? 128 MET A CG  1 
ATOM   839  S SD  . MET A 1 128 ? 28.989  -6.296  -12.745 1.00 10.20 ? 128 MET A SD  1 
ATOM   840  C CE  . MET A 1 128 ? 27.725  -5.537  -13.761 1.00 9.99  ? 128 MET A CE  1 
ATOM   841  N N   . LEU A 1 129 ? 25.971  -11.102 -13.800 1.00 10.04 ? 129 LEU A N   1 
ATOM   842  C CA  . LEU A 1 129 ? 25.004  -11.933 -13.099 1.00 10.43 ? 129 LEU A CA  1 
ATOM   843  C C   . LEU A 1 129 ? 25.370  -13.411 -13.286 1.00 11.01 ? 129 LEU A C   1 
ATOM   844  O O   . LEU A 1 129 ? 25.290  -14.189 -12.329 1.00 10.42 ? 129 LEU A O   1 
ATOM   845  C CB  . LEU A 1 129 ? 23.608  -11.618 -13.629 1.00 11.56 ? 129 LEU A CB  1 
ATOM   846  C CG  . LEU A 1 129 ? 22.487  -12.547 -13.160 1.00 12.58 ? 129 LEU A CG  1 
ATOM   847  C CD1 . LEU A 1 129 ? 22.425  -12.624 -11.667 1.00 13.00 ? 129 LEU A CD1 1 
ATOM   848  C CD2 . LEU A 1 129 ? 21.154  -12.031 -13.681 1.00 13.22 ? 129 LEU A CD2 1 
ATOM   849  N N   . ASP A 1 130 ? 25.722  -13.805 -14.523 1.00 10.69 ? 130 ASP A N   1 
ATOM   850  C CA  . ASP A 1 130 ? 26.136  -15.182 -14.792 1.00 11.79 ? 130 ASP A CA  1 
ATOM   851  C C   . ASP A 1 130 ? 27.315  -15.560 -13.890 1.00 11.40 ? 130 ASP A C   1 
ATOM   852  O O   . ASP A 1 130 ? 27.362  -16.660 -13.314 1.00 11.41 ? 130 ASP A O   1 
ATOM   853  C CB  . ASP A 1 130 ? 26.505  -15.450 -16.260 1.00 12.05 ? 130 ASP A CB  1 
ATOM   854  C CG  . ASP A 1 130 ? 25.374  -15.257 -17.276 1.00 14.21 ? 130 ASP A CG  1 
ATOM   855  O OD1 . ASP A 1 130 ? 24.183  -15.268 -16.872 1.00 15.71 ? 130 ASP A OD1 1 
ATOM   856  O OD2 . ASP A 1 130 ? 25.709  -14.964 -18.450 1.00 16.78 ? 130 ASP A OD2 1 
ATOM   857  N N   . TYR A 1 131 ? 28.271  -14.641 -13.756 1.00 11.18 ? 131 TYR A N   1 
ATOM   858  C CA  . TYR A 1 131 ? 29.417  -14.852 -12.890 1.00 11.41 ? 131 TYR A CA  1 
ATOM   859  C C   . TYR A 1 131 ? 28.979  -15.052 -11.429 1.00 11.11 ? 131 TYR A C   1 
ATOM   860  O O   . TYR A 1 131 ? 29.458  -15.966 -10.729 1.00 11.40 ? 131 TYR A O   1 
ATOM   861  C CB  . TYR A 1 131 ? 30.454  -13.735 -13.103 1.00 11.68 ? 131 TYR A CB  1 
ATOM   862  C CG  . TYR A 1 131 ? 31.529  -13.815 -12.037 1.00 14.42 ? 131 TYR A CG  1 
ATOM   863  C CD1 . TYR A 1 131 ? 32.620  -14.686 -12.129 1.00 16.83 ? 131 TYR A CD1 1 
ATOM   864  C CD2 . TYR A 1 131 ? 31.390  -13.069 -10.870 1.00 16.21 ? 131 TYR A CD2 1 
ATOM   865  C CE1 . TYR A 1 131 ? 33.563  -14.767 -11.103 1.00 18.83 ? 131 TYR A CE1 1 
ATOM   866  C CE2 . TYR A 1 131 ? 32.296  -13.179 -9.831  1.00 18.38 ? 131 TYR A CE2 1 
ATOM   867  C CZ  . TYR A 1 131 ? 33.381  -14.025 -9.945  1.00 20.22 ? 131 TYR A CZ  1 
ATOM   868  O OH  . TYR A 1 131 ? 34.201  -14.024 -8.852  1.00 25.50 ? 131 TYR A OH  1 
ATOM   869  N N   . PHE A 1 132 ? 28.133  -14.153 -10.918 1.00 10.28 ? 132 PHE A N   1 
ATOM   870  C CA  . PHE A 1 132 ? 27.702  -14.275 -9.532  1.00 10.46 ? 132 PHE A CA  1 
ATOM   871  C C   . PHE A 1 132 ? 26.959  -15.589 -9.296  1.00 10.86 ? 132 PHE A C   1 
ATOM   872  O O   . PHE A 1 132 ? 27.223  -16.236 -8.295  1.00 12.19 ? 132 PHE A O   1 
ATOM   873  C CB  . PHE A 1 132 ? 26.879  -13.052 -9.134  1.00 10.19 ? 132 PHE A CB  1 
ATOM   874  C CG  . PHE A 1 132 ? 27.630  -11.755 -9.250  1.00 10.05 ? 132 PHE A CG  1 
ATOM   875  C CD1 . PHE A 1 132 ? 28.907  -11.625 -8.737  1.00 10.84 ? 132 PHE A CD1 1 
ATOM   876  C CD2 . PHE A 1 132 ? 27.034  -10.647 -9.818  1.00 10.32 ? 132 PHE A CD2 1 
ATOM   877  C CE1 . PHE A 1 132 ? 29.582  -10.423 -8.822  1.00 11.39 ? 132 PHE A CE1 1 
ATOM   878  C CE2 . PHE A 1 132 ? 27.714  -9.457  -9.941  1.00 10.70 ? 132 PHE A CE2 1 
ATOM   879  C CZ  . PHE A 1 132 ? 28.978  -9.342  -9.423  1.00 11.45 ? 132 PHE A CZ  1 
ATOM   880  N N   . GLN A 1 133 ? 26.127  -16.046 -10.244 1.00 10.90 ? 133 GLN A N   1 
ATOM   881  C CA  . GLN A 1 133 ? 25.435  -17.316 -10.102 1.00 11.06 ? 133 GLN A CA  1 
ATOM   882  C C   . GLN A 1 133 ? 26.432  -18.477 -9.999  1.00 11.50 ? 133 GLN A C   1 
ATOM   883  O O   . GLN A 1 133 ? 26.159  -19.452 -9.303  1.00 11.27 ? 133 GLN A O   1 
ATOM   884  C CB  . GLN A 1 133 ? 24.462  -17.528 -11.254 1.00 11.24 ? 133 GLN A CB  1 
ATOM   885  C CG  . GLN A 1 133 ? 23.292  -16.561 -11.214 1.00 12.40 ? 133 GLN A CG  1 
ATOM   886  C CD  . GLN A 1 133 ? 22.379  -16.619 -12.411 1.00 15.18 ? 133 GLN A CD  1 
ATOM   887  O OE1 . GLN A 1 133 ? 21.171  -16.492 -12.280 1.00 20.58 ? 133 GLN A OE1 1 
ATOM   888  N NE2 . GLN A 1 133 ? 22.926  -16.771 -13.594 1.00 14.31 ? 133 GLN A NE2 1 
ATOM   889  N N   . GLU A 1 134 ? 27.560  -18.371 -10.710 1.00 12.06 ? 134 GLU A N   1 
ATOM   890  C CA  . GLU A 1 134 ? 28.605  -19.392 -10.721 1.00 12.92 ? 134 GLU A CA  1 
ATOM   891  C C   . GLU A 1 134 ? 29.379  -19.474 -9.414  1.00 14.05 ? 134 GLU A C   1 
ATOM   892  O O   . GLU A 1 134 ? 29.741  -20.572 -8.994  1.00 15.41 ? 134 GLU A O   1 
ATOM   893  C CB  . GLU A 1 134 ? 29.583  -19.125 -11.867 1.00 13.64 ? 134 GLU A CB  1 
ATOM   894  C CG  . GLU A 1 134 ? 28.985  -19.418 -13.221 1.00 12.42 ? 134 GLU A CG  1 
ATOM   895  C CD  . GLU A 1 134 ? 29.620  -18.678 -14.387 1.00 12.48 ? 134 GLU A CD  1 
ATOM   896  O OE1 . GLU A 1 134 ? 30.668  -18.054 -14.191 1.00 11.93 ? 134 GLU A OE1 1 
ATOM   897  O OE2 . GLU A 1 134 ? 29.025  -18.685 -15.477 1.00 13.32 ? 134 GLU A OE2 1 
ATOM   898  N N   . LYS A 1 135 ? 29.602  -18.345 -8.746  1.00 13.32 ? 135 LYS A N   1 
ATOM   899  C CA  . LYS A 1 135 ? 30.571  -18.271 -7.667  1.00 14.74 ? 135 LYS A CA  1 
ATOM   900  C C   . LYS A 1 135 ? 29.934  -18.122 -6.284  1.00 13.59 ? 135 LYS A C   1 
ATOM   901  O O   . LYS A 1 135 ? 30.638  -18.289 -5.282  1.00 13.39 ? 135 LYS A O   1 
ATOM   902  C CB  . LYS A 1 135 ? 31.531  -17.113 -7.939  1.00 18.01 ? 135 LYS A CB  1 
ATOM   903  C CG  . LYS A 1 135 ? 32.453  -17.358 -9.134  1.00 24.16 ? 135 LYS A CG  1 
ATOM   904  C CD  . LYS A 1 135 ? 33.203  -18.682 -9.094  1.00 29.00 ? 135 LYS A CD  1 
ATOM   905  C CE  . LYS A 1 135 ? 34.304  -18.770 -10.128 1.00 37.41 ? 135 LYS A CE  1 
ATOM   906  N NZ  . LYS A 1 135 ? 33.771  -19.067 -11.483 1.00 42.13 ? 135 LYS A NZ  1 
ATOM   907  N N   . PHE A 1 136 ? 28.652  -17.766 -6.253  1.00 12.07 ? 136 PHE A N   1 
ATOM   908  C CA  . PHE A 1 136 ? 27.924  -17.494 -5.026  1.00 12.08 ? 136 PHE A CA  1 
ATOM   909  C C   . PHE A 1 136 ? 26.606  -18.263 -5.044  1.00 12.77 ? 136 PHE A C   1 
ATOM   910  O O   . PHE A 1 136 ? 26.133  -18.667 -6.100  1.00 12.19 ? 136 PHE A O   1 
ATOM   911  C CB  . PHE A 1 136 ? 27.607  -16.001 -4.932  1.00 12.61 ? 136 PHE A CB  1 
ATOM   912  C CG  . PHE A 1 136 ? 28.823  -15.130 -4.825  1.00 13.40 ? 136 PHE A CG  1 
ATOM   913  C CD1 . PHE A 1 136 ? 29.386  -14.845 -3.594  1.00 14.79 ? 136 PHE A CD1 1 
ATOM   914  C CD2 . PHE A 1 136 ? 29.451  -14.652 -5.972  1.00 13.87 ? 136 PHE A CD2 1 
ATOM   915  C CE1 . PHE A 1 136 ? 30.528  -14.065 -3.509  1.00 15.90 ? 136 PHE A CE1 1 
ATOM   916  C CE2 . PHE A 1 136 ? 30.616  -13.901 -5.889  1.00 14.89 ? 136 PHE A CE2 1 
ATOM   917  C CZ  . PHE A 1 136 ? 31.144  -13.592 -4.653  1.00 14.26 ? 136 PHE A CZ  1 
ATOM   918  N N   . CYS A 1 137 ? 25.968  -18.400 -3.879  1.00 12.89 ? 137 CYS A N   1 
ATOM   919  C CA  . CYS A 1 137 ? 24.634  -18.977 -3.809  1.00 13.14 ? 137 CYS A CA  1 
ATOM   920  C C   . CYS A 1 137 ? 23.583  -17.890 -4.017  1.00 12.71 ? 137 CYS A C   1 
ATOM   921  O O   . CYS A 1 137 ? 23.071  -17.327 -3.056  1.00 13.45 ? 137 CYS A O   1 
ATOM   922  C CB  . CYS A 1 137 ? 24.432  -19.696 -2.481  1.00 13.66 ? 137 CYS A CB  1 
ATOM   923  S SG  . CYS A 1 137 ? 23.014  -20.811 -2.441  1.00 15.36 ? 137 CYS A SG  1 
ATOM   924  N N   . ILE A 1 138 ? 23.248  -17.634 -5.290  1.00 12.68 ? 138 ILE A N   1 
ATOM   925  C CA  . ILE A 1 138 ? 22.308  -16.589 -5.672  1.00 11.44 ? 138 ILE A CA  1 
ATOM   926  C C   . ILE A 1 138 ? 20.909  -17.167 -5.773  1.00 11.37 ? 138 ILE A C   1 
ATOM   927  O O   . ILE A 1 138 ? 20.696  -18.248 -6.345  1.00 12.12 ? 138 ILE A O   1 
ATOM   928  C CB  . ILE A 1 138 ? 22.710  -15.957 -7.022  1.00 12.32 ? 138 ILE A CB  1 
ATOM   929  C CG1 . ILE A 1 138 ? 24.132  -15.388 -7.008  1.00 11.88 ? 138 ILE A CG1 1 
ATOM   930  C CG2 . ILE A 1 138 ? 21.693  -14.897 -7.458  1.00 12.47 ? 138 ILE A CG2 1 
ATOM   931  C CD1 . ILE A 1 138 ? 24.417  -14.402 -5.889  1.00 12.20 ? 138 ILE A CD1 1 
ATOM   932  N N   . ASP A 1 139 ? 19.944  -16.425 -5.225  1.00 11.34 ? 139 ASP A N   1 
ATOM   933  C CA  . ASP A 1 139 ? 18.548  -16.698 -5.463  1.00 12.12 ? 139 ASP A CA  1 
ATOM   934  C C   . ASP A 1 139 ? 18.171  -16.015 -6.771  1.00 12.49 ? 139 ASP A C   1 
ATOM   935  O O   . ASP A 1 139 ? 18.025  -14.796 -6.782  1.00 11.69 ? 139 ASP A O   1 
ATOM   936  C CB  . ASP A 1 139 ? 17.670  -16.197 -4.312  1.00 12.95 ? 139 ASP A CB  1 
ATOM   937  C CG  . ASP A 1 139 ? 16.214  -16.564 -4.515  1.00 12.57 ? 139 ASP A CG  1 
ATOM   938  O OD1 . ASP A 1 139 ? 15.858  -16.898 -5.665  1.00 12.80 ? 139 ASP A OD1 1 
ATOM   939  O OD2 . ASP A 1 139 ? 15.426  -16.506 -3.507  1.00 13.68 ? 139 ASP A OD2 1 
ATOM   940  N N   . SER A 1 140 ? 18.017  -16.790 -7.854  1.00 12.80 ? 140 SER A N   1 
ATOM   941  C CA  . SER A 1 140 ? 17.913  -16.197 -9.175  1.00 13.57 ? 140 SER A CA  1 
ATOM   942  C C   . SER A 1 140 ? 16.539  -15.551 -9.401  1.00 12.28 ? 140 SER A C   1 
ATOM   943  O O   . SER A 1 140 ? 16.351  -14.812 -10.382 1.00 10.80 ? 140 SER A O   1 
ATOM   944  C CB  . SER A 1 140 ? 18.373  -17.197 -10.245 1.00 15.48 ? 140 SER A CB  1 
ATOM   945  O OG  . SER A 1 140 ? 19.811  -17.460 -10.080 1.00 17.19 ? 140 SER A OG  1 
ATOM   946  N N   . THR A 1 141 ? 15.629  -15.726 -8.432  1.00 12.45 ? 141 THR A N   1 
ATOM   947  C CA  . THR A 1 141 ? 14.320  -15.077 -8.433  1.00 11.64 ? 141 THR A CA  1 
ATOM   948  C C   . THR A 1 141 ? 14.338  -13.733 -7.694  1.00 11.12 ? 141 THR A C   1 
ATOM   949  O O   . THR A 1 141 ? 13.334  -12.997 -7.749  1.00 13.63 ? 141 THR A O   1 
ATOM   950  C CB  . THR A 1 141 ? 13.213  -15.998 -7.871  1.00 11.90 ? 141 THR A CB  1 
ATOM   951  O OG1 . THR A 1 141 ? 13.250  -16.042 -6.455  1.00 11.78 ? 141 THR A OG1 1 
ATOM   952  C CG2 . THR A 1 141 ? 13.258  -17.412 -8.401  1.00 13.51 ? 141 THR A CG2 1 
ATOM   953  N N   . ARG A 1 142 ? 15.472  -13.373 -7.066  1.00 10.77 ? 142 ARG A N   1 
ATOM   954  C CA  . ARG A 1 142 ? 15.596  -12.154 -6.271  1.00 10.74 ? 142 ARG A CA  1 
ATOM   955  C C   . ARG A 1 142 ? 16.874  -11.391 -6.618  1.00 9.55  ? 142 ARG A C   1 
ATOM   956  O O   . ARG A 1 142 ? 17.760  -11.168 -5.780  1.00 8.98  ? 142 ARG A O   1 
ATOM   957  C CB  . ARG A 1 142 ? 15.537  -12.529 -4.785  1.00 13.24 ? 142 ARG A CB  1 
ATOM   958  C CG  . ARG A 1 142 ? 14.148  -12.984 -4.366  1.00 16.36 ? 142 ARG A CG  1 
ATOM   959  C CD  . ARG A 1 142 ? 14.150  -13.912 -3.177  1.00 21.56 ? 142 ARG A CD  1 
ATOM   960  N NE  . ARG A 1 142 ? 14.620  -13.319 -1.967  1.00 24.98 ? 142 ARG A NE  1 
ATOM   961  C CZ  . ARG A 1 142 ? 15.314  -13.928 -0.993  1.00 31.55 ? 142 ARG A CZ  1 
ATOM   962  N NH1 . ARG A 1 142 ? 16.030  -15.043 -1.176  1.00 30.37 ? 142 ARG A NH1 1 
ATOM   963  N NH2 . ARG A 1 142 ? 15.316  -13.356 0.196   1.00 26.36 ? 142 ARG A NH2 1 
ATOM   964  N N   . VAL A 1 143 ? 16.937  -10.981 -7.886  1.00 8.75  ? 143 VAL A N   1 
ATOM   965  C CA  . VAL A 1 143 ? 17.989  -10.143 -8.415  1.00 8.36  ? 143 VAL A CA  1 
ATOM   966  C C   . VAL A 1 143 ? 17.348  -8.816  -8.795  1.00 8.45  ? 143 VAL A C   1 
ATOM   967  O O   . VAL A 1 143 ? 16.327  -8.801  -9.481  1.00 8.41  ? 143 VAL A O   1 
ATOM   968  C CB  . VAL A 1 143 ? 18.678  -10.797 -9.620  1.00 8.27  ? 143 VAL A CB  1 
ATOM   969  C CG1 . VAL A 1 143 ? 19.815  -9.930  -10.130 1.00 8.33  ? 143 VAL A CG1 1 
ATOM   970  C CG2 . VAL A 1 143 ? 19.160  -12.189 -9.251  1.00 8.44  ? 143 VAL A CG2 1 
ATOM   971  N N   . TYR A 1 144 ? 17.959  -7.723  -8.330  1.00 7.86  ? 144 TYR A N   1 
ATOM   972  C CA  . TYR A 1 144 ? 17.340  -6.418  -8.444  1.00 7.99  ? 144 TYR A CA  1 
ATOM   973  C C   . TYR A 1 144 ? 18.326  -5.407  -9.004  1.00 7.50  ? 144 TYR A C   1 
ATOM   974  O O   . TYR A 1 144 ? 19.550  -5.584  -8.953  1.00 8.27  ? 144 TYR A O   1 
ATOM   975  C CB  . TYR A 1 144 ? 16.847  -5.972  -7.063  1.00 8.56  ? 144 TYR A CB  1 
ATOM   976  C CG  . TYR A 1 144 ? 15.912  -6.960  -6.413  1.00 9.13  ? 144 TYR A CG  1 
ATOM   977  C CD1 . TYR A 1 144 ? 14.580  -7.031  -6.778  1.00 9.60  ? 144 TYR A CD1 1 
ATOM   978  C CD2 . TYR A 1 144 ? 16.376  -7.849  -5.454  1.00 11.32 ? 144 TYR A CD2 1 
ATOM   979  C CE1 . TYR A 1 144 ? 13.705  -7.924  -6.180  1.00 10.17 ? 144 TYR A CE1 1 
ATOM   980  C CE2 . TYR A 1 144 ? 15.519  -8.773  -4.869  1.00 11.20 ? 144 TYR A CE2 1 
ATOM   981  C CZ  . TYR A 1 144 ? 14.190  -8.811  -5.239  1.00 11.26 ? 144 TYR A CZ  1 
ATOM   982  O OH  . TYR A 1 144 ? 13.380  -9.709  -4.614  1.00 12.75 ? 144 TYR A OH  1 
ATOM   983  N N   . ALA A 1 145 ? 17.773  -4.307  -9.509  1.00 7.73  ? 145 ALA A N   1 
ATOM   984  C CA  . ALA A 1 145 ? 18.567  -3.193  -10.018 1.00 7.29  ? 145 ALA A CA  1 
ATOM   985  C C   . ALA A 1 145 ? 18.002  -1.860  -9.536  1.00 7.54  ? 145 ALA A C   1 
ATOM   986  O O   . ALA A 1 145 ? 16.782  -1.622  -9.600  1.00 6.85  ? 145 ALA A O   1 
ATOM   987  C CB  . ALA A 1 145 ? 18.602  -3.260  -11.532 1.00 7.77  ? 145 ALA A CB  1 
ATOM   988  N N   . ALA A 1 146 ? 18.926  -0.981  -9.099  1.00 7.63  ? 146 ALA A N   1 
ATOM   989  C CA  . ALA A 1 146 ? 18.640  0.404   -8.744  1.00 7.92  ? 146 ALA A CA  1 
ATOM   990  C C   . ALA A 1 146 ? 19.759  1.292   -9.267  1.00 8.29  ? 146 ALA A C   1 
ATOM   991  O O   . ALA A 1 146 ? 20.853  0.815   -9.596  1.00 9.23  ? 146 ALA A O   1 
ATOM   992  C CB  . ALA A 1 146 ? 18.529  0.556   -7.250  1.00 7.82  ? 146 ALA A CB  1 
ATOM   993  N N   . GLY A 1 147 ? 19.475  2.585   -9.392  1.00 8.09  ? 147 GLY A N   1 
ATOM   994  C CA  . GLY A 1 147 ? 20.485  3.502   -9.870  1.00 8.05  ? 147 GLY A CA  1 
ATOM   995  C C   . GLY A 1 147 ? 20.082  4.962   -9.731  1.00 8.52  ? 147 GLY A C   1 
ATOM   996  O O   . GLY A 1 147 ? 18.894  5.296   -9.681  1.00 7.80  ? 147 GLY A O   1 
ATOM   997  N N   . LYS A 1 148 ? 21.107  5.819   -9.628  1.00 9.19  ? 148 LYS A N   1 
ATOM   998  C CA  . LYS A 1 148 ? 20.905  7.254   -9.644  1.00 9.92  ? 148 LYS A CA  1 
ATOM   999  C C   . LYS A 1 148 ? 21.102  7.815   -11.055 1.00 10.60 ? 148 LYS A C   1 
ATOM   1000 O O   . LYS A 1 148 ? 22.177  7.647   -11.614 1.00 9.71  ? 148 LYS A O   1 
ATOM   1001 C CB  . LYS A 1 148 ? 21.896  7.906   -8.678  1.00 9.60  ? 148 LYS A CB  1 
ATOM   1002 C CG  . LYS A 1 148 ? 21.885  9.431   -8.721  1.00 9.97  ? 148 LYS A CG  1 
ATOM   1003 C CD  . LYS A 1 148 ? 20.679  10.099  -8.056  1.00 9.81  ? 148 LYS A CD  1 
ATOM   1004 C CE  . LYS A 1 148 ? 20.581  11.575  -8.381  1.00 10.00 ? 148 LYS A CE  1 
ATOM   1005 N NZ  . LYS A 1 148 ? 21.816  12.319  -7.991  1.00 9.69  ? 148 LYS A NZ  1 
ATOM   1006 N N   . SER A 1 149 ? 20.116  8.552   -11.593 1.00 12.24 ? 149 SER A N   1 
ATOM   1007 C CA  . SER A 1 149 ? 20.285  9.453   -12.762 1.00 14.50 ? 149 SER A CA  1 
ATOM   1008 C C   . SER A 1 149 ? 20.667  8.727   -14.074 1.00 12.99 ? 149 SER A C   1 
ATOM   1009 O O   . SER A 1 149 ? 19.845  7.988   -14.574 1.00 12.71 ? 149 SER A O   1 
ATOM   1010 C CB  . SER A 1 149 ? 21.192  10.616  -12.434 1.00 16.47 ? 149 SER A CB  1 
ATOM   1011 O OG  . SER A 1 149 ? 21.108  11.611  -13.460 1.00 21.11 ? 149 SER A OG  1 
ATOM   1012 N N   . ASN A 1 150 ? 21.875  8.906   -14.663 1.00 11.02 ? 150 ASN A N   1 
ATOM   1013 C CA  . ASN A 1 150 ? 22.334  8.020   -15.740 1.00 10.37 ? 150 ASN A CA  1 
ATOM   1014 C C   . ASN A 1 150 ? 22.168  6.550   -15.329 1.00 9.09  ? 150 ASN A C   1 
ATOM   1015 O O   . ASN A 1 150 ? 21.815  5.716   -16.131 1.00 9.26  ? 150 ASN A O   1 
ATOM   1016 C CB  . ASN A 1 150 ? 23.800  8.286   -16.103 1.00 10.06 ? 150 ASN A CB  1 
ATOM   1017 C CG  . ASN A 1 150 ? 24.299  7.671   -17.394 1.00 10.29 ? 150 ASN A CG  1 
ATOM   1018 O OD1 . ASN A 1 150 ? 25.468  7.850   -17.719 1.00 10.81 ? 150 ASN A OD1 1 
ATOM   1019 N ND2 . ASN A 1 150 ? 23.483  6.941   -18.131 1.00 10.41 ? 150 ASN A ND2 1 
ATOM   1020 N N   . GLY A 1 151 ? 22.429  6.227   -14.068 1.00 9.20  ? 151 GLY A N   1 
ATOM   1021 C CA  . GLY A 1 151 ? 22.301  4.859   -13.586 1.00 9.31  ? 151 GLY A CA  1 
ATOM   1022 C C   . GLY A 1 151 ? 20.845  4.400   -13.437 1.00 9.16  ? 151 GLY A C   1 
ATOM   1023 O O   . GLY A 1 151 ? 20.567  3.195   -13.474 1.00 9.45  ? 151 GLY A O   1 
ATOM   1024 N N   . GLY A 1 152 ? 19.950  5.350   -13.186 1.00 9.44  ? 152 GLY A N   1 
ATOM   1025 C CA  . GLY A 1 152 ? 18.515  5.139   -13.154 1.00 9.53  ? 152 GLY A CA  1 
ATOM   1026 C C   . GLY A 1 152 ? 17.946  4.917   -14.557 1.00 9.62  ? 152 GLY A C   1 
ATOM   1027 O O   . GLY A 1 152 ? 17.116  4.048   -14.794 1.00 9.71  ? 152 GLY A O   1 
ATOM   1028 N N   . GLY A 1 153 ? 18.397  5.742   -15.498 1.00 9.38  ? 153 GLY A N   1 
ATOM   1029 C CA  . GLY A 1 153 ? 18.180  5.501   -16.913 1.00 9.40  ? 153 GLY A CA  1 
ATOM   1030 C C   . GLY A 1 153 ? 18.629  4.103   -17.315 1.00 9.23  ? 153 GLY A C   1 
ATOM   1031 O O   . GLY A 1 153 ? 17.902  3.416   -18.007 1.00 9.70  ? 153 GLY A O   1 
ATOM   1032 N N   . PHE A 1 154 ? 19.799  3.670   -16.838 1.00 9.27  ? 154 PHE A N   1 
ATOM   1033 C CA  . PHE A 1 154 ? 20.307  2.351   -17.197 1.00 9.09  ? 154 PHE A CA  1 
ATOM   1034 C C   . PHE A 1 154 ? 19.466  1.266   -16.533 1.00 9.15  ? 154 PHE A C   1 
ATOM   1035 O O   . PHE A 1 154 ? 19.113  0.280   -17.186 1.00 8.01  ? 154 PHE A O   1 
ATOM   1036 C CB  . PHE A 1 154 ? 21.782  2.192   -16.851 1.00 9.32  ? 154 PHE A CB  1 
ATOM   1037 C CG  . PHE A 1 154 ? 22.270  0.859   -17.323 1.00 8.86  ? 154 PHE A CG  1 
ATOM   1038 C CD1 . PHE A 1 154 ? 22.353  0.596   -18.676 1.00 8.79  ? 154 PHE A CD1 1 
ATOM   1039 C CD2 . PHE A 1 154 ? 22.465  -0.174  -16.427 1.00 8.86  ? 154 PHE A CD2 1 
ATOM   1040 C CE1 . PHE A 1 154 ? 22.710  -0.661  -19.118 1.00 8.81  ? 154 PHE A CE1 1 
ATOM   1041 C CE2 . PHE A 1 154 ? 22.760  -1.457  -16.876 1.00 8.59  ? 154 PHE A CE2 1 
ATOM   1042 C CZ  . PHE A 1 154 ? 22.899  -1.692  -18.219 1.00 8.39  ? 154 PHE A CZ  1 
ATOM   1043 N N   . THR A 1 155 ? 19.059  1.511   -15.274 1.00 8.41  ? 155 THR A N   1 
ATOM   1044 C CA  . THR A 1 155 ? 18.123  0.614   -14.619 1.00 8.32  ? 155 THR A CA  1 
ATOM   1045 C C   . THR A 1 155 ? 16.879  0.415   -15.489 1.00 9.19  ? 155 THR A C   1 
ATOM   1046 O O   . THR A 1 155 ? 16.419  -0.706  -15.686 1.00 9.54  ? 155 THR A O   1 
ATOM   1047 C CB  . THR A 1 155 ? 17.760  1.159   -13.233 1.00 8.32  ? 155 THR A CB  1 
ATOM   1048 O OG1 . THR A 1 155 ? 18.928  1.062   -12.409 1.00 7.29  ? 155 THR A OG1 1 
ATOM   1049 C CG2 . THR A 1 155 ? 16.614  0.414   -12.582 1.00 8.13  ? 155 THR A CG2 1 
ATOM   1050 N N   . ASN A 1 156 ? 16.293  1.511   -15.952 1.00 9.86  ? 156 ASN A N   1 
ATOM   1051 C CA  . ASN A 1 156 ? 15.150  1.445   -16.843 1.00 10.65 ? 156 ASN A CA  1 
ATOM   1052 C C   . ASN A 1 156 ? 15.479  0.680   -18.131 1.00 10.87 ? 156 ASN A C   1 
ATOM   1053 O O   . ASN A 1 156 ? 14.636  -0.081  -18.629 1.00 10.70 ? 156 ASN A O   1 
ATOM   1054 C CB  . ASN A 1 156 ? 14.622  2.838   -17.168 1.00 11.37 ? 156 ASN A CB  1 
ATOM   1055 C CG  . ASN A 1 156 ? 13.273  2.790   -17.865 1.00 12.36 ? 156 ASN A CG  1 
ATOM   1056 O OD1 . ASN A 1 156 ? 12.313  2.266   -17.312 1.00 12.81 ? 156 ASN A OD1 1 
ATOM   1057 N ND2 . ASN A 1 156 ? 13.201  3.337   -19.068 1.00 12.39 ? 156 ASN A ND2 1 
ATOM   1058 N N   . LEU A 1 157 ? 16.661  0.914   -18.733 1.00 11.36 ? 157 LEU A N   1 
ATOM   1059 C CA  . LEU A 1 157 ? 17.016  0.174   -19.941 1.00 11.19 ? 157 LEU A CA  1 
ATOM   1060 C C   . LEU A 1 157 ? 17.003  -1.333  -19.698 1.00 10.33 ? 157 LEU A C   1 
ATOM   1061 O O   . LEU A 1 157 ? 16.671  -2.098  -20.630 1.00 10.08 ? 157 LEU A O   1 
ATOM   1062 C CB  . LEU A 1 157 ? 18.364  0.627   -20.523 1.00 12.49 ? 157 LEU A CB  1 
ATOM   1063 C CG  . LEU A 1 157 ? 18.411  2.033   -21.125 1.00 13.62 ? 157 LEU A CG  1 
ATOM   1064 C CD1 . LEU A 1 157 ? 19.766  2.315   -21.754 1.00 13.93 ? 157 LEU A CD1 1 
ATOM   1065 C CD2 . LEU A 1 157 ? 17.308  2.242   -22.166 1.00 15.56 ? 157 LEU A CD2 1 
ATOM   1066 N N   . LEU A 1 158 ? 17.378  -1.764  -18.475 1.00 9.41  ? 158 LEU A N   1 
ATOM   1067 C CA  . LEU A 1 158 ? 17.352  -3.170  -18.132 1.00 9.65  ? 158 LEU A CA  1 
ATOM   1068 C C   . LEU A 1 158 ? 15.904  -3.678  -18.164 1.00 9.97  ? 158 LEU A C   1 
ATOM   1069 O O   . LEU A 1 158 ? 15.647  -4.741  -18.713 1.00 9.96  ? 158 LEU A O   1 
ATOM   1070 C CB  . LEU A 1 158 ? 18.013  -3.410  -16.760 1.00 9.59  ? 158 LEU A CB  1 
ATOM   1071 C CG  . LEU A 1 158 ? 19.537  -3.262  -16.697 1.00 10.09 ? 158 LEU A CG  1 
ATOM   1072 C CD1 . LEU A 1 158 ? 20.006  -3.255  -15.261 1.00 10.95 ? 158 LEU A CD1 1 
ATOM   1073 C CD2 . LEU A 1 158 ? 20.275  -4.375  -17.455 1.00 9.99  ? 158 LEU A CD2 1 
ATOM   1074 N N   . ALA A 1 159 ? 14.973  -2.914  -17.571 1.00 10.09 ? 159 ALA A N   1 
ATOM   1075 C CA  . ALA A 1 159 ? 13.566  -3.268  -17.534 1.00 10.58 ? 159 ALA A CA  1 
ATOM   1076 C C   . ALA A 1 159 ? 12.988  -3.275  -18.938 1.00 10.65 ? 159 ALA A C   1 
ATOM   1077 O O   . ALA A 1 159 ? 11.980  -3.938  -19.159 1.00 11.13 ? 159 ALA A O   1 
ATOM   1078 C CB  . ALA A 1 159 ? 12.802  -2.303  -16.664 1.00 10.69 ? 159 ALA A CB  1 
ATOM   1079 N N   . CYS A 1 160 ? 13.624  -2.511  -19.849 1.00 11.47 ? 160 CYS A N   1 
ATOM   1080 C CA  . CYS A 1 160 ? 13.140  -2.286  -21.199 1.00 12.06 ? 160 CYS A CA  1 
ATOM   1081 C C   . CYS A 1 160 ? 13.778  -3.251  -22.203 1.00 12.45 ? 160 CYS A C   1 
ATOM   1082 O O   . CYS A 1 160 ? 13.417  -3.261  -23.388 1.00 11.25 ? 160 CYS A O   1 
ATOM   1083 C CB  . CYS A 1 160 ? 13.367  -0.837  -21.595 1.00 12.79 ? 160 CYS A CB  1 
ATOM   1084 S SG  . CYS A 1 160 ? 12.134  0.250   -20.851 1.00 15.37 ? 160 CYS A SG  1 
ATOM   1085 N N   . ASP A 1 161 ? 14.647  -4.128  -21.694 1.00 12.59 ? 161 ASP A N   1 
ATOM   1086 C CA  . ASP A 1 161 ? 15.390  -5.066  -22.526 1.00 12.66 ? 161 ASP A CA  1 
ATOM   1087 C C   . ASP A 1 161 ? 14.687  -6.417  -22.499 1.00 12.52 ? 161 ASP A C   1 
ATOM   1088 O O   . ASP A 1 161 ? 14.481  -6.991  -21.416 1.00 11.97 ? 161 ASP A O   1 
ATOM   1089 C CB  . ASP A 1 161 ? 16.836  -5.254  -22.048 1.00 11.96 ? 161 ASP A CB  1 
ATOM   1090 C CG  . ASP A 1 161 ? 17.637  -6.194  -22.937 1.00 14.38 ? 161 ASP A CG  1 
ATOM   1091 O OD1 . ASP A 1 161 ? 17.982  -5.769  -24.048 1.00 15.92 ? 161 ASP A OD1 1 
ATOM   1092 O OD2 . ASP A 1 161 ? 17.928  -7.309  -22.514 1.00 14.39 ? 161 ASP A OD2 1 
ATOM   1093 N N   . PRO A 1 162 ? 14.363  -7.010  -23.672 1.00 13.62 ? 162 PRO A N   1 
ATOM   1094 C CA  . PRO A 1 162 ? 13.675  -8.299  -23.682 1.00 15.09 ? 162 PRO A CA  1 
ATOM   1095 C C   . PRO A 1 162 ? 14.329  -9.364  -22.799 1.00 13.62 ? 162 PRO A C   1 
ATOM   1096 O O   . PRO A 1 162 ? 13.572  -10.046 -22.115 1.00 14.83 ? 162 PRO A O   1 
ATOM   1097 C CB  . PRO A 1 162 ? 13.562  -8.661  -25.186 1.00 15.25 ? 162 PRO A CB  1 
ATOM   1098 C CG  . PRO A 1 162 ? 13.586  -7.307  -25.892 1.00 14.47 ? 162 PRO A CG  1 
ATOM   1099 C CD  . PRO A 1 162 ? 14.512  -6.456  -25.035 1.00 14.23 ? 162 PRO A CD  1 
ATOM   1100 N N   . THR A 1 163 ? 15.680  -9.463  -22.726 1.00 13.04 ? 163 THR A N   1 
ATOM   1101 C CA  . THR A 1 163 ? 16.331  -10.502 -21.925 1.00 13.54 ? 163 THR A CA  1 
ATOM   1102 C C   . THR A 1 163 ? 16.479  -10.080 -20.457 1.00 12.93 ? 163 THR A C   1 
ATOM   1103 O O   . THR A 1 163 ? 16.057  -10.800 -19.531 1.00 12.18 ? 163 THR A O   1 
ATOM   1104 C CB  . THR A 1 163 ? 17.677  -10.909 -22.551 1.00 17.05 ? 163 THR A CB  1 
ATOM   1105 O OG1 . THR A 1 163 ? 17.376  -11.503 -23.809 1.00 17.22 ? 163 THR A OG1 1 
ATOM   1106 C CG2 . THR A 1 163 ? 18.511  -11.856 -21.724 1.00 16.61 ? 163 THR A CG2 1 
ATOM   1107 N N   . ALA A 1 164 ? 17.037  -8.889  -20.229 1.00 11.26 ? 164 ALA A N   1 
ATOM   1108 C CA  . ALA A 1 164 ? 17.402  -8.502  -18.870 1.00 11.51 ? 164 ALA A CA  1 
ATOM   1109 C C   . ALA A 1 164 ? 16.155  -8.372  -17.993 1.00 10.95 ? 164 ALA A C   1 
ATOM   1110 O O   . ALA A 1 164 ? 16.187  -8.731  -16.819 1.00 11.20 ? 164 ALA A O   1 
ATOM   1111 C CB  . ALA A 1 164 ? 18.194  -7.231  -18.878 1.00 10.97 ? 164 ALA A CB  1 
ATOM   1112 N N   . SER A 1 165 ? 15.046  -7.978  -18.611 1.00 9.49  ? 165 SER A N   1 
ATOM   1113 C CA  . SER A 1 165 ? 13.793  -7.798  -17.906 1.00 9.92  ? 165 SER A CA  1 
ATOM   1114 C C   . SER A 1 165 ? 13.226  -9.137  -17.445 1.00 11.12 ? 165 SER A C   1 
ATOM   1115 O O   . SER A 1 165 ? 12.379  -9.131  -16.559 1.00 11.20 ? 165 SER A O   1 
ATOM   1116 C CB  . SER A 1 165 ? 12.807  -7.053  -18.736 1.00 9.89  ? 165 SER A CB  1 
ATOM   1117 O OG  . SER A 1 165 ? 12.436  -7.796  -19.920 1.00 9.82  ? 165 SER A OG  1 
ATOM   1118 N N   . THR A 1 166 ? 13.677  -10.258 -18.039 1.00 10.87 ? 166 THR A N   1 
ATOM   1119 C CA  . THR A 1 166 ? 13.229  -11.570 -17.611 1.00 12.10 ? 166 THR A CA  1 
ATOM   1120 C C   . THR A 1 166 ? 14.139  -12.181 -16.560 1.00 11.54 ? 166 THR A C   1 
ATOM   1121 O O   . THR A 1 166 ? 13.813  -13.255 -16.045 1.00 11.02 ? 166 THR A O   1 
ATOM   1122 C CB  . THR A 1 166 ? 13.056  -12.550 -18.778 1.00 13.51 ? 166 THR A CB  1 
ATOM   1123 O OG1 . THR A 1 166 ? 14.293  -12.800 -19.444 1.00 14.80 ? 166 THR A OG1 1 
ATOM   1124 C CG2 . THR A 1 166 ? 12.022  -12.038 -19.753 1.00 14.59 ? 166 THR A CG2 1 
ATOM   1125 N N   . ARG A 1 167 ? 15.246  -11.510 -16.220 1.00 9.99  ? 167 ARG A N   1 
ATOM   1126 C CA  . ARG A 1 167 ? 16.197  -12.060 -15.267 1.00 9.92  ? 167 ARG A CA  1 
ATOM   1127 C C   . ARG A 1 167 ? 16.244  -11.225 -13.992 1.00 9.69  ? 167 ARG A C   1 
ATOM   1128 O O   . ARG A 1 167 ? 16.732  -11.692 -12.956 1.00 10.52 ? 167 ARG A O   1 
ATOM   1129 C CB  . ARG A 1 167 ? 17.573  -12.176 -15.929 1.00 10.61 ? 167 ARG A CB  1 
ATOM   1130 C CG  . ARG A 1 167 ? 17.585  -13.108 -17.136 1.00 10.81 ? 167 ARG A CG  1 
ATOM   1131 C CD  . ARG A 1 167 ? 18.981  -13.390 -17.645 1.00 11.79 ? 167 ARG A CD  1 
ATOM   1132 N NE  . ARG A 1 167 ? 19.772  -14.131 -16.676 1.00 11.97 ? 167 ARG A NE  1 
ATOM   1133 C CZ  . ARG A 1 167 ? 21.088  -14.227 -16.689 1.00 13.54 ? 167 ARG A CZ  1 
ATOM   1134 N NH1 . ARG A 1 167 ? 21.791  -13.658 -17.655 1.00 15.38 ? 167 ARG A NH1 1 
ATOM   1135 N NH2 . ARG A 1 167 ? 21.701  -14.958 -15.774 1.00 15.96 ? 167 ARG A NH2 1 
ATOM   1136 N N   . ILE A 1 168 ? 15.782  -9.968  -14.072 1.00 10.26 ? 168 ILE A N   1 
ATOM   1137 C CA  . ILE A 1 168 ? 15.820  -9.062  -12.938 1.00 9.96  ? 168 ILE A CA  1 
ATOM   1138 C C   . ILE A 1 168 ? 14.382  -8.876  -12.469 1.00 10.92 ? 168 ILE A C   1 
ATOM   1139 O O   . ILE A 1 168 ? 13.488  -8.542  -13.272 1.00 9.91  ? 168 ILE A O   1 
ATOM   1140 C CB  . ILE A 1 168 ? 16.499  -7.738  -13.325 1.00 10.69 ? 168 ILE A CB  1 
ATOM   1141 C CG1 . ILE A 1 168 ? 17.914  -8.022  -13.826 1.00 11.05 ? 168 ILE A CG1 1 
ATOM   1142 C CG2 . ILE A 1 168 ? 16.471  -6.713  -12.180 1.00 10.59 ? 168 ILE A CG2 1 
ATOM   1143 C CD1 . ILE A 1 168 ? 18.612  -6.841  -14.379 1.00 11.73 ? 168 ILE A CD1 1 
ATOM   1144 N N   . ALA A 1 169 ? 14.173  -9.089  -11.160 1.00 10.52 ? 169 ALA A N   1 
ATOM   1145 C CA  . ALA A 1 169 ? 12.831  -9.155  -10.569 1.00 9.87  ? 169 ALA A CA  1 
ATOM   1146 C C   . ALA A 1 169 ? 12.150  -7.801  -10.422 1.00 9.98  ? 169 ALA A C   1 
ATOM   1147 O O   . ALA A 1 169 ? 10.912  -7.709  -10.518 1.00 10.72 ? 169 ALA A O   1 
ATOM   1148 C CB  . ALA A 1 169 ? 12.901  -9.817  -9.213  1.00 10.16 ? 169 ALA A CB  1 
ATOM   1149 N N   . ALA A 1 170 ? 12.917  -6.749  -10.111 1.00 9.71  ? 170 ALA A N   1 
ATOM   1150 C CA  . ALA A 1 170 ? 12.311  -5.440  -9.851  1.00 8.95  ? 170 ALA A CA  1 
ATOM   1151 C C   . ALA A 1 170 ? 13.368  -4.339  -10.024 1.00 8.59  ? 170 ALA A C   1 
ATOM   1152 O O   . ALA A 1 170 ? 14.574  -4.627  -9.970  1.00 8.82  ? 170 ALA A O   1 
ATOM   1153 C CB  . ALA A 1 170 ? 11.650  -5.382  -8.492  1.00 8.89  ? 170 ALA A CB  1 
ATOM   1154 N N   . PHE A 1 171 ? 12.892  -3.097  -10.200 1.00 7.58  ? 171 PHE A N   1 
ATOM   1155 C CA  . PHE A 1 171 ? 13.699  -1.983  -10.673 1.00 8.01  ? 171 PHE A CA  1 
ATOM   1156 C C   . PHE A 1 171 ? 13.366  -0.696  -9.913  1.00 8.02  ? 171 PHE A C   1 
ATOM   1157 O O   . PHE A 1 171 ? 12.185  -0.343  -9.786  1.00 8.11  ? 171 PHE A O   1 
ATOM   1158 C CB  . PHE A 1 171 ? 13.445  -1.778  -12.178 1.00 8.50  ? 171 PHE A CB  1 
ATOM   1159 C CG  . PHE A 1 171 ? 13.699  -3.006  -13.017 1.00 8.21  ? 171 PHE A CG  1 
ATOM   1160 C CD1 . PHE A 1 171 ? 12.726  -3.979  -13.144 1.00 8.57  ? 171 PHE A CD1 1 
ATOM   1161 C CD2 . PHE A 1 171 ? 14.907  -3.180  -13.667 1.00 7.85  ? 171 PHE A CD2 1 
ATOM   1162 C CE1 . PHE A 1 171 ? 12.967  -5.108  -13.912 1.00 9.29  ? 171 PHE A CE1 1 
ATOM   1163 C CE2 . PHE A 1 171 ? 15.149  -4.307  -14.433 1.00 8.65  ? 171 PHE A CE2 1 
ATOM   1164 C CZ  . PHE A 1 171 ? 14.189  -5.272  -14.551 1.00 9.04  ? 171 PHE A CZ  1 
ATOM   1165 N N   . ALA A 1 172 ? 14.402  0.034   -9.476  1.00 7.92  ? 172 ALA A N   1 
ATOM   1166 C CA  . ALA A 1 172 ? 14.232  1.258   -8.686  1.00 7.55  ? 172 ALA A CA  1 
ATOM   1167 C C   . ALA A 1 172 ? 15.145  2.372   -9.199  1.00 7.85  ? 172 ALA A C   1 
ATOM   1168 O O   . ALA A 1 172 ? 16.209  2.651   -8.636  1.00 7.63  ? 172 ALA A O   1 
ATOM   1169 C CB  . ALA A 1 172 ? 14.518  1.008   -7.220  1.00 7.75  ? 172 ALA A CB  1 
ATOM   1170 N N   . PRO A 1 173 ? 14.755  3.059   -10.280 1.00 7.77  ? 173 PRO A N   1 
ATOM   1171 C CA  . PRO A 1 173 ? 15.440  4.269   -10.732 1.00 8.19  ? 173 PRO A CA  1 
ATOM   1172 C C   . PRO A 1 173 ? 15.172  5.470   -9.841  1.00 8.27  ? 173 PRO A C   1 
ATOM   1173 O O   . PRO A 1 173 ? 14.026  5.757   -9.468  1.00 8.89  ? 173 PRO A O   1 
ATOM   1174 C CB  . PRO A 1 173 ? 14.863  4.521   -12.132 1.00 8.77  ? 173 PRO A CB  1 
ATOM   1175 C CG  . PRO A 1 173 ? 13.525  3.885   -12.084 1.00 8.64  ? 173 PRO A CG  1 
ATOM   1176 C CD  . PRO A 1 173 ? 13.660  2.682   -11.177 1.00 8.15  ? 173 PRO A CD  1 
ATOM   1177 N N   . VAL A 1 174 ? 16.262  6.144   -9.475  1.00 7.73  ? 174 VAL A N   1 
ATOM   1178 C CA  . VAL A 1 174 ? 16.209  7.295   -8.595  1.00 7.55  ? 174 VAL A CA  1 
ATOM   1179 C C   . VAL A 1 174 ? 16.686  8.484   -9.401  1.00 7.98  ? 174 VAL A C   1 
ATOM   1180 O O   . VAL A 1 174 ? 17.842  8.528   -9.806  1.00 7.87  ? 174 VAL A O   1 
ATOM   1181 C CB  . VAL A 1 174 ? 17.050  7.053   -7.327  1.00 7.41  ? 174 VAL A CB  1 
ATOM   1182 C CG1 . VAL A 1 174 ? 17.131  8.267   -6.410  1.00 7.65  ? 174 VAL A CG1 1 
ATOM   1183 C CG2 . VAL A 1 174 ? 16.517  5.863   -6.561  1.00 7.48  ? 174 VAL A CG2 1 
ATOM   1184 N N   . SER A 1 175 ? 15.785  9.440   -9.632  1.00 8.10  ? 175 SER A N   1 
ATOM   1185 C CA  . SER A 1 175 ? 16.083  10.625  -10.408 1.00 8.44  ? 175 SER A CA  1 
ATOM   1186 C C   . SER A 1 175 ? 16.635  10.226  -11.779 1.00 8.53  ? 175 SER A C   1 
ATOM   1187 O O   . SER A 1 175 ? 17.514  10.891  -12.303 1.00 9.23  ? 175 SER A O   1 
ATOM   1188 C CB  . SER A 1 175 ? 17.018  11.577  -9.673  1.00 8.47  ? 175 SER A CB  1 
ATOM   1189 O OG  . SER A 1 175 ? 16.569  11.884  -8.355  1.00 8.60  ? 175 SER A OG  1 
ATOM   1190 N N   . GLY A 1 176 ? 16.012  9.219   -12.413 1.00 9.20  ? 176 GLY A N   1 
ATOM   1191 C CA  . GLY A 1 176 ? 16.587  8.612   -13.601 1.00 9.41  ? 176 GLY A CA  1 
ATOM   1192 C C   . GLY A 1 176 ? 16.417  9.514   -14.822 1.00 9.64  ? 176 GLY A C   1 
ATOM   1193 O O   . GLY A 1 176 ? 15.443  10.261  -14.930 1.00 10.33 ? 176 GLY A O   1 
ATOM   1194 N N   . ALA A 1 177 ? 17.380  9.384   -15.736 1.00 10.13 ? 177 ALA A N   1 
ATOM   1195 C CA  . ALA A 1 177 ? 17.469  10.124  -16.989 1.00 10.07 ? 177 ALA A CA  1 
ATOM   1196 C C   . ALA A 1 177 ? 17.143  9.199   -18.169 1.00 9.66  ? 177 ALA A C   1 
ATOM   1197 O O   . ALA A 1 177 ? 18.002  8.420   -18.602 1.00 8.92  ? 177 ALA A O   1 
ATOM   1198 C CB  . ALA A 1 177 ? 18.888  10.674  -17.084 1.00 10.19 ? 177 ALA A CB  1 
ATOM   1199 N N   . TYR A 1 178 ? 15.892  9.263   -18.645 1.00 9.73  ? 178 TYR A N   1 
ATOM   1200 C CA  . TYR A 1 178 ? 15.342  8.290   -19.584 1.00 10.17 ? 178 TYR A CA  1 
ATOM   1201 C C   . TYR A 1 178 ? 15.440  8.898   -20.999 1.00 10.92 ? 178 TYR A C   1 
ATOM   1202 O O   . TYR A 1 178 ? 14.439  9.154   -21.668 1.00 10.82 ? 178 TYR A O   1 
ATOM   1203 C CB  . TYR A 1 178 ? 13.917  7.898   -19.140 1.00 9.95  ? 178 TYR A CB  1 
ATOM   1204 C CG  . TYR A 1 178 ? 13.769  7.660   -17.653 1.00 8.99  ? 178 TYR A CG  1 
ATOM   1205 C CD1 . TYR A 1 178 ? 14.502  6.661   -17.016 1.00 9.92  ? 178 TYR A CD1 1 
ATOM   1206 C CD2 . TYR A 1 178 ? 12.993  8.483   -16.867 1.00 9.02  ? 178 TYR A CD2 1 
ATOM   1207 C CE1 . TYR A 1 178 ? 14.403  6.449   -15.649 1.00 8.95  ? 178 TYR A CE1 1 
ATOM   1208 C CE2 . TYR A 1 178 ? 12.891  8.296   -15.506 1.00 8.58  ? 178 TYR A CE2 1 
ATOM   1209 C CZ  . TYR A 1 178 ? 13.637  7.310   -14.893 1.00 8.75  ? 178 TYR A CZ  1 
ATOM   1210 O OH  . TYR A 1 178 ? 13.597  7.190   -13.541 1.00 9.47  ? 178 TYR A OH  1 
ATOM   1211 N N   . TYR A 1 179 ? 16.679  9.098   -21.471 1.00 11.63 ? 179 TYR A N   1 
ATOM   1212 C CA  . TYR A 1 179 ? 16.955  9.859   -22.678 1.00 12.02 ? 179 TYR A CA  1 
ATOM   1213 C C   . TYR A 1 179 ? 16.336  9.176   -23.878 1.00 12.72 ? 179 TYR A C   1 
ATOM   1214 O O   . TYR A 1 179 ? 16.492  7.956   -24.031 1.00 11.88 ? 179 TYR A O   1 
ATOM   1215 C CB  . TYR A 1 179 ? 18.450  10.015  -22.973 1.00 12.60 ? 179 TYR A CB  1 
ATOM   1216 C CG  . TYR A 1 179 ? 19.093  11.181  -22.245 1.00 12.59 ? 179 TYR A CG  1 
ATOM   1217 C CD1 . TYR A 1 179 ? 18.914  12.481  -22.704 1.00 12.72 ? 179 TYR A CD1 1 
ATOM   1218 C CD2 . TYR A 1 179 ? 19.815  10.989  -21.078 1.00 12.92 ? 179 TYR A CD2 1 
ATOM   1219 C CE1 . TYR A 1 179 ? 19.462  13.558  -22.030 1.00 12.56 ? 179 TYR A CE1 1 
ATOM   1220 C CE2 . TYR A 1 179 ? 20.361  12.063  -20.386 1.00 12.81 ? 179 TYR A CE2 1 
ATOM   1221 C CZ  . TYR A 1 179 ? 20.193  13.354  -20.877 1.00 13.52 ? 179 TYR A CZ  1 
ATOM   1222 O OH  . TYR A 1 179 ? 20.721  14.435  -20.213 1.00 14.48 ? 179 TYR A OH  1 
ATOM   1223 N N   . GLN A 1 180 ? 15.642  9.980   -24.699 1.00 13.23 ? 180 GLN A N   1 
ATOM   1224 C CA  . GLN A 1 180 ? 15.059  9.483   -25.936 1.00 14.28 ? 180 GLN A CA  1 
ATOM   1225 C C   . GLN A 1 180 ? 15.801  10.177  -27.083 1.00 16.26 ? 180 GLN A C   1 
ATOM   1226 O O   . GLN A 1 180 ? 16.208  11.323  -26.986 1.00 15.03 ? 180 GLN A O   1 
ATOM   1227 C CB  . GLN A 1 180 ? 13.543  9.715   -25.925 1.00 14.74 ? 180 GLN A CB  1 
ATOM   1228 C CG  . GLN A 1 180 ? 12.787  9.052   -24.781 1.00 15.95 ? 180 GLN A CG  1 
ATOM   1229 C CD  . GLN A 1 180 ? 13.068  7.562   -24.728 1.00 17.04 ? 180 GLN A CD  1 
ATOM   1230 O OE1 . GLN A 1 180 ? 13.034  6.862   -25.744 1.00 18.35 ? 180 GLN A OE1 1 
ATOM   1231 N NE2 . GLN A 1 180 ? 13.442  7.086   -23.556 1.00 15.29 ? 180 GLN A NE2 1 
ATOM   1232 N N   . ASP A 1 181 ? 15.994  9.458   -28.178 1.00 20.44 ? 181 ASP A N   1 
ATOM   1233 C CA  . ASP A 1 181 ? 16.795  9.932   -29.288 1.00 26.10 ? 181 ASP A CA  1 
ATOM   1234 C C   . ASP A 1 181 ? 15.909  10.802  -30.183 1.00 27.03 ? 181 ASP A C   1 
ATOM   1235 O O   . ASP A 1 181 ? 15.469  10.386  -31.261 1.00 28.07 ? 181 ASP A O   1 
ATOM   1236 C CB  . ASP A 1 181 ? 17.421  8.723   -29.987 1.00 32.28 ? 181 ASP A CB  1 
ATOM   1237 C CG  . ASP A 1 181 ? 18.225  9.093   -31.221 1.00 38.09 ? 181 ASP A CG  1 
ATOM   1238 O OD1 . ASP A 1 181 ? 19.189  9.891   -31.093 1.00 43.40 ? 181 ASP A OD1 1 
ATOM   1239 O OD2 . ASP A 1 181 ? 17.856  8.593   -32.301 1.00 43.90 ? 181 ASP A OD2 1 
ATOM   1240 N N   . VAL A 1 182 ? 15.564  11.978  -29.657 1.00 23.33 ? 182 VAL A N   1 
ATOM   1241 C CA  . VAL A 1 182 ? 14.657  12.923  -30.299 1.00 21.61 ? 182 VAL A CA  1 
ATOM   1242 C C   . VAL A 1 182 ? 15.290  14.289  -30.047 1.00 21.91 ? 182 VAL A C   1 
ATOM   1243 O O   . VAL A 1 182 ? 15.797  14.509  -28.940 1.00 18.30 ? 182 VAL A O   1 
ATOM   1244 C CB  . VAL A 1 182 ? 13.230  12.820  -29.716 1.00 20.72 ? 182 VAL A CB  1 
ATOM   1245 C CG1 . VAL A 1 182 ? 12.360  13.996  -30.133 1.00 22.24 ? 182 VAL A CG1 1 
ATOM   1246 C CG2 . VAL A 1 182 ? 12.531  11.506  -30.074 1.00 19.80 ? 182 VAL A CG2 1 
ATOM   1247 N N   . SER A 1 183 ? 15.337  15.162  -31.068 1.00 18.37 ? 183 SER A N   1 
ATOM   1248 C CA  . SER A 1 183 ? 16.028  16.443  -30.942 1.00 18.32 ? 183 SER A CA  1 
ATOM   1249 C C   . SER A 1 183 ? 15.288  17.350  -29.938 1.00 16.77 ? 183 SER A C   1 
ATOM   1250 O O   . SER A 1 183 ? 14.081  17.211  -29.722 1.00 14.56 ? 183 SER A O   1 
ATOM   1251 C CB  . SER A 1 183 ? 16.150  17.097  -32.304 1.00 20.48 ? 183 SER A CB  1 
ATOM   1252 O OG  . SER A 1 183 ? 14.875  17.586  -32.733 1.00 20.53 ? 183 SER A OG  1 
ATOM   1253 N N   . GLU A 1 184 ? 16.010  18.310  -29.334 1.00 15.65 ? 184 GLU A N   1 
ATOM   1254 C CA  . GLU A 1 184 ? 15.371  19.243  -28.412 1.00 15.83 ? 184 GLU A CA  1 
ATOM   1255 C C   . GLU A 1 184 ? 14.178  19.912  -29.112 1.00 16.91 ? 184 GLU A C   1 
ATOM   1256 O O   . GLU A 1 184 ? 13.129  20.108  -28.498 1.00 17.03 ? 184 GLU A O   1 
ATOM   1257 C CB  . GLU A 1 184 ? 16.345  20.307  -27.892 1.00 15.06 ? 184 GLU A CB  1 
ATOM   1258 C CG  . GLU A 1 184 ? 17.571  19.734  -27.194 1.00 14.65 ? 184 GLU A CG  1 
ATOM   1259 C CD  . GLU A 1 184 ? 18.188  20.558  -26.076 1.00 13.88 ? 184 GLU A CD  1 
ATOM   1260 O OE1 . GLU A 1 184 ? 17.496  21.456  -25.539 1.00 13.88 ? 184 GLU A OE1 1 
ATOM   1261 O OE2 . GLU A 1 184 ? 19.371  20.266  -25.687 1.00 12.62 ? 184 GLU A OE2 1 
ATOM   1262 N N   . GLU A 1 185 ? 14.332  20.274  -30.393 1.00 17.44 ? 185 GLU A N   1 
ATOM   1263 C CA  . GLU A 1 185 ? 13.288  21.059  -31.049 1.00 22.91 ? 185 GLU A CA  1 
ATOM   1264 C C   . GLU A 1 185 ? 11.993  20.254  -31.195 1.00 21.94 ? 185 GLU A C   1 
ATOM   1265 O O   . GLU A 1 185 ? 10.894  20.809  -31.168 1.00 22.68 ? 185 GLU A O   1 
ATOM   1266 C CB  . GLU A 1 185 ? 13.757  21.572  -32.407 1.00 28.78 ? 185 GLU A CB  1 
ATOM   1267 C CG  . GLU A 1 185 ? 12.921  22.749  -32.890 1.00 38.98 ? 185 GLU A CG  1 
ATOM   1268 C CD  . GLU A 1 185 ? 13.173  23.171  -34.328 1.00 49.81 ? 185 GLU A CD  1 
ATOM   1269 O OE1 . GLU A 1 185 ? 14.344  23.451  -34.664 1.00 58.80 ? 185 GLU A OE1 1 
ATOM   1270 O OE2 . GLU A 1 185 ? 12.198  23.220  -35.111 1.00 56.12 ? 185 GLU A OE2 1 
ATOM   1271 N N   . ALA A 1 186 ? 12.136  18.940  -31.375 1.00 21.63 ? 186 ALA A N   1 
ATOM   1272 C CA  . ALA A 1 186 ? 11.003  18.043  -31.568 1.00 20.46 ? 186 ALA A CA  1 
ATOM   1273 C C   . ALA A 1 186 ? 10.523  17.444  -30.239 1.00 19.83 ? 186 ALA A C   1 
ATOM   1274 O O   . ALA A 1 186 ? 9.539   16.709  -30.200 1.00 18.75 ? 186 ALA A O   1 
ATOM   1275 C CB  . ALA A 1 186 ? 11.425  16.985  -32.556 1.00 22.06 ? 186 ALA A CB  1 
ATOM   1276 N N   . CYS A 1 187 ? 11.199  17.792  -29.132 1.00 19.39 ? 187 CYS A N   1 
ATOM   1277 C CA  . CYS A 1 187 ? 10.957  17.169  -27.837 1.00 20.04 ? 187 CYS A CA  1 
ATOM   1278 C C   . CYS A 1 187 ? 9.654   17.683  -27.231 1.00 22.03 ? 187 CYS A C   1 
ATOM   1279 O O   . CYS A 1 187 ? 9.546   18.861  -26.910 1.00 21.06 ? 187 CYS A O   1 
ATOM   1280 C CB  . CYS A 1 187 ? 12.140  17.424  -26.892 1.00 19.54 ? 187 CYS A CB  1 
ATOM   1281 S SG  . CYS A 1 187 ? 11.979  16.685  -25.244 1.00 17.86 ? 187 CYS A SG  1 
ATOM   1282 N N   . HIS A 1 188 ? 8.688   16.773  -27.055 1.00 19.33 ? 188 HIS A N   1 
ATOM   1283 C CA  . HIS A 1 188 ? 7.445   17.045  -26.353 1.00 23.07 ? 188 HIS A CA  1 
ATOM   1284 C C   . HIS A 1 188 ? 7.355   16.088  -25.168 1.00 18.80 ? 188 HIS A C   1 
ATOM   1285 O O   . HIS A 1 188 ? 6.890   14.945  -25.329 1.00 17.63 ? 188 HIS A O   1 
ATOM   1286 C CB  . HIS A 1 188 ? 6.235   16.897  -27.286 1.00 24.46 ? 188 HIS A CB  1 
ATOM   1287 C CG  . HIS A 1 188 ? 6.225   17.907  -28.373 1.00 33.28 ? 188 HIS A CG  1 
ATOM   1288 N ND1 . HIS A 1 188 ? 6.773   17.678  -29.618 1.00 36.76 ? 188 HIS A ND1 1 
ATOM   1289 C CD2 . HIS A 1 188 ? 5.818   19.175  -28.375 1.00 37.04 ? 188 HIS A CD2 1 
ATOM   1290 C CE1 . HIS A 1 188 ? 6.621   18.754  -30.367 1.00 35.29 ? 188 HIS A CE1 1 
ATOM   1291 N NE2 . HIS A 1 188 ? 6.053   19.678  -29.629 1.00 39.51 ? 188 HIS A NE2 1 
ATOM   1292 N N   . PRO A 1 189 ? 7.807   16.534  -23.970 1.00 15.99 ? 189 PRO A N   1 
ATOM   1293 C CA  . PRO A 1 189 ? 8.117   15.610  -22.877 1.00 16.08 ? 189 PRO A CA  1 
ATOM   1294 C C   . PRO A 1 189 ? 6.901   14.872  -22.317 1.00 16.12 ? 189 PRO A C   1 
ATOM   1295 O O   . PRO A 1 189 ? 7.048   13.807  -21.733 1.00 13.63 ? 189 PRO A O   1 
ATOM   1296 C CB  . PRO A 1 189 ? 8.774   16.482  -21.787 1.00 15.52 ? 189 PRO A CB  1 
ATOM   1297 C CG  . PRO A 1 189 ? 8.385   17.888  -22.125 1.00 17.80 ? 189 PRO A CG  1 
ATOM   1298 C CD  . PRO A 1 189 ? 8.113   17.935  -23.629 1.00 15.86 ? 189 PRO A CD  1 
ATOM   1299 N N   . THR A 1 190 ? 5.686   15.391  -22.540 1.00 17.76 ? 190 THR A N   1 
ATOM   1300 C CA  . THR A 1 190 ? 4.514   14.721  -22.006 1.00 17.10 ? 190 THR A CA  1 
ATOM   1301 C C   . THR A 1 190 ? 4.000   13.663  -22.968 1.00 17.05 ? 190 THR A C   1 
ATOM   1302 O O   . THR A 1 190 ? 3.182   12.848  -22.554 1.00 17.61 ? 190 THR A O   1 
ATOM   1303 C CB  . THR A 1 190 ? 3.399   15.686  -21.592 1.00 20.43 ? 190 THR A CB  1 
ATOM   1304 O OG1 . THR A 1 190 ? 2.913   16.218  -22.805 1.00 23.21 ? 190 THR A OG1 1 
ATOM   1305 C CG2 . THR A 1 190 ? 3.830   16.792  -20.658 1.00 21.71 ? 190 THR A CG2 1 
ATOM   1306 N N   . THR A 1 191 ? 4.521   13.595  -24.199 1.00 17.36 ? 191 THR A N   1 
ATOM   1307 C CA  . THR A 1 191 ? 4.037   12.622  -25.159 1.00 19.66 ? 191 THR A CA  1 
ATOM   1308 C C   . THR A 1 191 ? 5.155   11.852  -25.855 1.00 20.66 ? 191 THR A C   1 
ATOM   1309 O O   . THR A 1 191 ? 4.843   10.876  -26.540 1.00 21.03 ? 191 THR A O   1 
ATOM   1310 C CB  . THR A 1 191 ? 3.146   13.253  -26.246 1.00 20.78 ? 191 THR A CB  1 
ATOM   1311 O OG1 . THR A 1 191 ? 3.895   14.263  -26.914 1.00 19.80 ? 191 THR A OG1 1 
ATOM   1312 C CG2 . THR A 1 191 ? 1.867   13.851  -25.692 1.00 22.06 ? 191 THR A CG2 1 
ATOM   1313 N N   . VAL A 1 192 ? 6.431   12.229  -25.658 1.00 15.96 ? 192 VAL A N   1 
ATOM   1314 C CA  . VAL A 1 192 ? 7.523   11.611  -26.392 1.00 15.36 ? 192 VAL A CA  1 
ATOM   1315 C C   . VAL A 1 192 ? 7.475   10.087  -26.233 1.00 16.65 ? 192 VAL A C   1 
ATOM   1316 O O   . VAL A 1 192 ? 7.295   9.563   -25.133 1.00 15.65 ? 192 VAL A O   1 
ATOM   1317 C CB  . VAL A 1 192 ? 8.899   12.160  -25.969 1.00 14.41 ? 192 VAL A CB  1 
ATOM   1318 C CG1 . VAL A 1 192 ? 9.215   11.932  -24.491 1.00 14.62 ? 192 VAL A CG1 1 
ATOM   1319 C CG2 . VAL A 1 192 ? 10.027  11.613  -26.838 1.00 15.32 ? 192 VAL A CG2 1 
ATOM   1320 N N   . PRO A 1 193 ? 7.626   9.292   -27.312 1.00 17.18 ? 193 PRO A N   1 
ATOM   1321 C CA  . PRO A 1 193 ? 7.680   7.840   -27.137 1.00 17.71 ? 193 PRO A CA  1 
ATOM   1322 C C   . PRO A 1 193 ? 8.918   7.471   -26.313 1.00 17.76 ? 193 PRO A C   1 
ATOM   1323 O O   . PRO A 1 193 ? 9.989   8.052   -26.463 1.00 17.97 ? 193 PRO A O   1 
ATOM   1324 C CB  . PRO A 1 193 ? 7.732   7.268   -28.561 1.00 19.59 ? 193 PRO A CB  1 
ATOM   1325 C CG  . PRO A 1 193 ? 7.159   8.391   -29.412 1.00 19.43 ? 193 PRO A CG  1 
ATOM   1326 C CD  . PRO A 1 193 ? 7.588   9.688   -28.731 1.00 19.43 ? 193 PRO A CD  1 
ATOM   1327 N N   . ILE A 1 194 ? 8.725   6.496   -25.425 1.00 15.20 ? 194 ILE A N   1 
ATOM   1328 C CA  . ILE A 1 194 ? 9.782   5.961   -24.616 1.00 15.72 ? 194 ILE A CA  1 
ATOM   1329 C C   . ILE A 1 194 ? 10.079  4.563   -25.146 1.00 17.45 ? 194 ILE A C   1 
ATOM   1330 O O   . ILE A 1 194 ? 9.220   3.680   -25.094 1.00 18.05 ? 194 ILE A O   1 
ATOM   1331 C CB  . ILE A 1 194 ? 9.351   5.975   -23.138 1.00 16.68 ? 194 ILE A CB  1 
ATOM   1332 C CG1 . ILE A 1 194 ? 9.140   7.412   -22.635 1.00 15.20 ? 194 ILE A CG1 1 
ATOM   1333 C CG2 . ILE A 1 194 ? 10.331  5.160   -22.299 1.00 16.71 ? 194 ILE A CG2 1 
ATOM   1334 C CD1 . ILE A 1 194 ? 8.419   7.533   -21.300 1.00 15.88 ? 194 ILE A CD1 1 
ATOM   1335 N N   . LYS A 1 195 ? 11.300  4.387   -25.651 1.00 16.22 ? 195 LYS A N   1 
ATOM   1336 C CA  . LYS A 1 195 ? 11.673  3.171   -26.324 1.00 18.19 ? 195 LYS A CA  1 
ATOM   1337 C C   . LYS A 1 195 ? 11.850  2.106   -25.251 1.00 16.70 ? 195 LYS A C   1 
ATOM   1338 O O   . LYS A 1 195 ? 12.636  2.333   -24.323 1.00 15.73 ? 195 LYS A O   1 
ATOM   1339 C CB  . LYS A 1 195 ? 12.968  3.400   -27.106 1.00 21.43 ? 195 LYS A CB  1 
ATOM   1340 C CG  . LYS A 1 195 ? 13.410  2.228   -27.970 1.00 27.44 ? 195 LYS A CG  1 
ATOM   1341 C CD  . LYS A 1 195 ? 14.834  2.377   -28.457 1.00 33.48 ? 195 LYS A CD  1 
ATOM   1342 C CE  . LYS A 1 195 ? 15.026  1.978   -29.905 1.00 43.78 ? 195 LYS A CE  1 
ATOM   1343 N NZ  . LYS A 1 195 ? 15.012  0.508   -30.075 1.00 49.49 ? 195 LYS A NZ  1 
ATOM   1344 N N   . CYS A 1 196 ? 11.073  1.011   -25.353 1.00 16.60 ? 196 CYS A N   1 
ATOM   1345 C CA  . CYS A 1 196 ? 11.011  0.020   -24.290 1.00 17.72 ? 196 CYS A CA  1 
ATOM   1346 C C   . CYS A 1 196 ? 10.377  -1.277  -24.806 1.00 18.82 ? 196 CYS A C   1 
ATOM   1347 O O   . CYS A 1 196 ? 9.284   -1.226  -25.356 1.00 17.58 ? 196 CYS A O   1 
ATOM   1348 C CB  . CYS A 1 196 ? 10.187  0.579   -23.134 1.00 17.41 ? 196 CYS A CB  1 
ATOM   1349 S SG  . CYS A 1 196 ? 10.292  -0.398  -21.613 1.00 16.53 ? 196 CYS A SG  1 
ATOM   1350 N N   . SER A 1 197 ? 11.018  -2.438  -24.583 1.00 18.99 ? 197 SER A N   1 
ATOM   1351 C CA  . SER A 1 197 ? 10.450  -3.722  -24.997 1.00 19.42 ? 197 SER A CA  1 
ATOM   1352 C C   . SER A 1 197 ? 10.570  -4.776  -23.903 1.00 16.29 ? 197 SER A C   1 
ATOM   1353 O O   . SER A 1 197 ? 11.334  -5.727  -24.042 1.00 16.04 ? 197 SER A O   1 
ATOM   1354 C CB  . SER A 1 197 ? 11.095  -4.243  -26.264 1.00 22.88 ? 197 SER A CB  1 
ATOM   1355 O OG  . SER A 1 197 ? 11.077  -3.257  -27.284 1.00 26.70 ? 197 SER A OG  1 
ATOM   1356 N N   . PRO A 1 198 ? 9.801   -4.700  -22.801 1.00 16.18 ? 198 PRO A N   1 
ATOM   1357 C CA  . PRO A 1 198 ? 9.953   -5.671  -21.704 1.00 16.37 ? 198 PRO A CA  1 
ATOM   1358 C C   . PRO A 1 198 ? 9.626   -7.073  -22.211 1.00 15.74 ? 198 PRO A C   1 
ATOM   1359 O O   . PRO A 1 198 ? 8.834   -7.219  -23.142 1.00 13.33 ? 198 PRO A O   1 
ATOM   1360 C CB  . PRO A 1 198 ? 8.960   -5.244  -20.613 1.00 17.06 ? 198 PRO A CB  1 
ATOM   1361 C CG  . PRO A 1 198 ? 8.299   -3.965  -21.114 1.00 17.79 ? 198 PRO A CG  1 
ATOM   1362 C CD  . PRO A 1 198 ? 8.716   -3.752  -22.565 1.00 17.40 ? 198 PRO A CD  1 
ATOM   1363 N N   . GLY A 1 199 ? 10.290  -8.083  -21.633 1.00 15.02 ? 199 GLY A N   1 
ATOM   1364 C CA  . GLY A 1 199 ? 10.118  -9.457  -22.062 1.00 14.35 ? 199 GLY A CA  1 
ATOM   1365 C C   . GLY A 1 199 ? 9.082   -10.211 -21.254 1.00 14.05 ? 199 GLY A C   1 
ATOM   1366 O O   . GLY A 1 199 ? 8.895   -11.391 -21.492 1.00 14.59 ? 199 GLY A O   1 
ATOM   1367 N N   . ARG A 1 200 ? 8.417   -9.553  -20.303 1.00 13.76 ? 200 ARG A N   1 
ATOM   1368 C CA  . ARG A 1 200 ? 7.400   -10.227 -19.510 1.00 14.77 ? 200 ARG A CA  1 
ATOM   1369 C C   . ARG A 1 200 ? 6.420   -9.176  -19.011 1.00 16.14 ? 200 ARG A C   1 
ATOM   1370 O O   . ARG A 1 200 ? 6.751   -7.991  -18.974 1.00 16.13 ? 200 ARG A O   1 
ATOM   1371 C CB  . ARG A 1 200 ? 8.027   -11.009 -18.338 1.00 15.27 ? 200 ARG A CB  1 
ATOM   1372 C CG  . ARG A 1 200 ? 8.646   -10.126 -17.263 1.00 14.29 ? 200 ARG A CG  1 
ATOM   1373 C CD  . ARG A 1 200 ? 9.262   -10.906 -16.090 1.00 14.28 ? 200 ARG A CD  1 
ATOM   1374 N NE  . ARG A 1 200 ? 10.101  -10.013 -15.277 1.00 14.47 ? 200 ARG A NE  1 
ATOM   1375 C CZ  . ARG A 1 200 ? 9.760   -9.491  -14.094 1.00 15.10 ? 200 ARG A CZ  1 
ATOM   1376 N NH1 . ARG A 1 200 ? 8.593   -9.778  -13.532 1.00 14.51 ? 200 ARG A NH1 1 
ATOM   1377 N NH2 . ARG A 1 200 ? 10.615  -8.721  -13.436 1.00 13.95 ? 200 ARG A NH2 1 
ATOM   1378 N N   . PRO A 1 201 ? 5.186   -9.568  -18.618 1.00 19.13 ? 201 PRO A N   1 
ATOM   1379 C CA  . PRO A 1 201 ? 4.243   -8.639  -18.007 1.00 19.42 ? 201 PRO A CA  1 
ATOM   1380 C C   . PRO A 1 201 ? 4.618   -8.344  -16.555 1.00 17.74 ? 201 PRO A C   1 
ATOM   1381 O O   . PRO A 1 201 ? 5.467   -9.010  -15.984 1.00 15.85 ? 201 PRO A O   1 
ATOM   1382 C CB  . PRO A 1 201 ? 2.907   -9.391  -18.125 1.00 19.99 ? 201 PRO A CB  1 
ATOM   1383 C CG  . PRO A 1 201 ? 3.303   -10.838 -18.006 1.00 20.89 ? 201 PRO A CG  1 
ATOM   1384 C CD  . PRO A 1 201 ? 4.607   -10.916 -18.781 1.00 21.68 ? 201 PRO A CD  1 
ATOM   1385 N N   . SER A 1 202 ? 3.983   -7.316  -15.998 1.00 17.89 ? 202 SER A N   1 
ATOM   1386 C CA  . SER A 1 202 ? 3.980   -7.079  -14.561 1.00 20.51 ? 202 SER A CA  1 
ATOM   1387 C C   . SER A 1 202 ? 5.384   -6.758  -14.066 1.00 17.49 ? 202 SER A C   1 
ATOM   1388 O O   . SER A 1 202 ? 5.810   -7.349  -13.082 1.00 16.13 ? 202 SER A O   1 
ATOM   1389 C CB  . SER A 1 202 ? 3.391   -8.264  -13.813 1.00 21.98 ? 202 SER A CB  1 
ATOM   1390 O OG  . SER A 1 202 ? 2.038   -8.435  -14.233 1.00 22.57 ? 202 SER A OG  1 
ATOM   1391 N N   . ILE A 1 203 ? 6.092   -5.867  -14.784 1.00 13.72 ? 203 ILE A N   1 
ATOM   1392 C CA  . ILE A 1 203 ? 7.402   -5.417  -14.331 1.00 13.80 ? 203 ILE A CA  1 
ATOM   1393 C C   . ILE A 1 203 ? 7.245   -4.443  -13.181 1.00 11.65 ? 203 ILE A C   1 
ATOM   1394 O O   . ILE A 1 203 ? 6.594   -3.414  -13.347 1.00 11.28 ? 203 ILE A O   1 
ATOM   1395 C CB  . ILE A 1 203 ? 8.226   -4.756  -15.451 1.00 14.69 ? 203 ILE A CB  1 
ATOM   1396 C CG1 . ILE A 1 203 ? 8.355   -5.639  -16.701 1.00 15.29 ? 203 ILE A CG1 1 
ATOM   1397 C CG2 . ILE A 1 203 ? 9.588   -4.308  -14.911 1.00 15.06 ? 203 ILE A CG2 1 
ATOM   1398 C CD1 . ILE A 1 203 ? 9.559   -6.472  -16.729 1.00 15.76 ? 203 ILE A CD1 1 
ATOM   1399 N N   . PRO A 1 204 ? 7.863   -4.719  -12.002 1.00 11.17 ? 204 PRO A N   1 
ATOM   1400 C CA  . PRO A 1 204 ? 7.835   -3.771  -10.884 1.00 10.30 ? 204 PRO A CA  1 
ATOM   1401 C C   . PRO A 1 204 ? 8.843   -2.639  -11.043 1.00 9.80  ? 204 PRO A C   1 
ATOM   1402 O O   . PRO A 1 204 ? 10.032  -2.882  -11.236 1.00 10.13 ? 204 PRO A O   1 
ATOM   1403 C CB  . PRO A 1 204 ? 8.126   -4.642  -9.658  1.00 10.47 ? 204 PRO A CB  1 
ATOM   1404 C CG  . PRO A 1 204 ? 8.044   -6.066  -10.160 1.00 10.79 ? 204 PRO A CG  1 
ATOM   1405 C CD  . PRO A 1 204 ? 8.468   -5.996  -11.601 1.00 10.09 ? 204 PRO A CD  1 
ATOM   1406 N N   . ILE A 1 205 ? 8.349   -1.408  -10.920 1.00 9.25  ? 205 ILE A N   1 
ATOM   1407 C CA  . ILE A 1 205 ? 9.126   -0.193  -11.112 1.00 10.24 ? 205 ILE A CA  1 
ATOM   1408 C C   . ILE A 1 205 ? 8.790   0.701   -9.930  1.00 9.44  ? 205 ILE A C   1 
ATOM   1409 O O   . ILE A 1 205 ? 7.595   0.961   -9.653  1.00 9.93  ? 205 ILE A O   1 
ATOM   1410 C CB  . ILE A 1 205 ? 8.773   0.562   -12.411 1.00 12.14 ? 205 ILE A CB  1 
ATOM   1411 C CG1 . ILE A 1 205 ? 8.903   -0.276  -13.690 1.00 13.54 ? 205 ILE A CG1 1 
ATOM   1412 C CG2 . ILE A 1 205 ? 9.564   1.873   -12.541 1.00 13.35 ? 205 ILE A CG2 1 
ATOM   1413 C CD1 . ILE A 1 205 ? 10.316  -0.660  -14.058 1.00 13.85 ? 205 ILE A CD1 1 
ATOM   1414 N N   . LEU A 1 206 ? 9.844   1.191   -9.299  1.00 8.63  ? 206 LEU A N   1 
ATOM   1415 C CA  . LEU A 1 206 ? 9.765   2.171   -8.242  1.00 8.90  ? 206 LEU A CA  1 
ATOM   1416 C C   . LEU A 1 206 ? 10.659  3.337   -8.650  1.00 9.59  ? 206 LEU A C   1 
ATOM   1417 O O   . LEU A 1 206 ? 11.886  3.192   -8.745  1.00 10.79 ? 206 LEU A O   1 
ATOM   1418 C CB  . LEU A 1 206 ? 10.227  1.508   -6.946  1.00 8.58  ? 206 LEU A CB  1 
ATOM   1419 C CG  . LEU A 1 206 ? 10.526  2.455   -5.790  1.00 9.08  ? 206 LEU A CG  1 
ATOM   1420 C CD1 . LEU A 1 206 ? 9.265   3.224   -5.386  1.00 8.85  ? 206 LEU A CD1 1 
ATOM   1421 C CD2 . LEU A 1 206 ? 11.072  1.684   -4.579  1.00 9.13  ? 206 LEU A CD2 1 
ATOM   1422 N N   . GLU A 1 207 ? 10.058  4.514   -8.848  1.00 9.08  ? 207 GLU A N   1 
ATOM   1423 C CA  . GLU A 1 207 ? 10.779  5.707   -9.282  1.00 8.65  ? 207 GLU A CA  1 
ATOM   1424 C C   . GLU A 1 207 ? 10.620  6.826   -8.263  1.00 8.88  ? 207 GLU A C   1 
ATOM   1425 O O   . GLU A 1 207 ? 9.504   7.121   -7.832  1.00 8.31  ? 207 GLU A O   1 
ATOM   1426 C CB  . GLU A 1 207 ? 10.301  6.181   -10.654 1.00 8.58  ? 207 GLU A CB  1 
ATOM   1427 C CG  . GLU A 1 207 ? 11.306  7.011   -11.417 1.00 8.47  ? 207 GLU A CG  1 
ATOM   1428 C CD  . GLU A 1 207 ? 11.453  8.498   -11.153 1.00 8.39  ? 207 GLU A CD  1 
ATOM   1429 O OE1 . GLU A 1 207 ? 10.669  9.061   -10.416 1.00 8.62  ? 207 GLU A OE1 1 
ATOM   1430 O OE2 . GLU A 1 207 ? 12.375  9.095   -11.765 1.00 9.50  ? 207 GLU A OE2 1 
ATOM   1431 N N   . PHE A 1 208 ? 11.765  7.391   -7.846  1.00 8.29  ? 208 PHE A N   1 
ATOM   1432 C CA  . PHE A 1 208 ? 11.829  8.570   -6.990  1.00 8.65  ? 208 PHE A CA  1 
ATOM   1433 C C   . PHE A 1 208 ? 12.262  9.758   -7.842  1.00 9.00  ? 208 PHE A C   1 
ATOM   1434 O O   . PHE A 1 208 ? 13.124  9.580   -8.736  1.00 8.11  ? 208 PHE A O   1 
ATOM   1435 C CB  . PHE A 1 208 ? 12.864  8.396   -5.875  1.00 8.81  ? 208 PHE A CB  1 
ATOM   1436 C CG  . PHE A 1 208 ? 12.510  7.380   -4.822  1.00 9.72  ? 208 PHE A CG  1 
ATOM   1437 C CD1 . PHE A 1 208 ? 12.668  6.027   -5.057  1.00 10.48 ? 208 PHE A CD1 1 
ATOM   1438 C CD2 . PHE A 1 208 ? 11.942  7.781   -3.625  1.00 10.45 ? 208 PHE A CD2 1 
ATOM   1439 C CE1 . PHE A 1 208 ? 12.343  5.093   -4.082  1.00 10.82 ? 208 PHE A CE1 1 
ATOM   1440 C CE2 . PHE A 1 208 ? 11.586  6.848   -2.668  1.00 10.77 ? 208 PHE A CE2 1 
ATOM   1441 C CZ  . PHE A 1 208 ? 11.800  5.512   -2.897  1.00 11.07 ? 208 PHE A CZ  1 
ATOM   1442 N N   . HIS A 1 209 ? 11.649  10.933  -7.594  1.00 8.88  ? 209 HIS A N   1 
ATOM   1443 C CA  . HIS A 1 209 ? 12.061  12.129  -8.322  1.00 9.34  ? 209 HIS A CA  1 
ATOM   1444 C C   . HIS A 1 209 ? 11.689  13.365  -7.522  1.00 9.51  ? 209 HIS A C   1 
ATOM   1445 O O   . HIS A 1 209 ? 10.649  13.380  -6.843  1.00 10.36 ? 209 HIS A O   1 
ATOM   1446 C CB  . HIS A 1 209 ? 11.462  12.155  -9.732  1.00 9.35  ? 209 HIS A CB  1 
ATOM   1447 C CG  . HIS A 1 209 ? 12.429  12.572  -10.784 1.00 9.27  ? 209 HIS A CG  1 
ATOM   1448 N ND1 . HIS A 1 209 ? 12.996  11.631  -11.633 1.00 9.10  ? 209 HIS A ND1 1 
ATOM   1449 C CD2 . HIS A 1 209 ? 12.999  13.758  -11.086 1.00 9.48  ? 209 HIS A CD2 1 
ATOM   1450 C CE1 . HIS A 1 209 ? 13.867  12.249  -12.435 1.00 9.06  ? 209 HIS A CE1 1 
ATOM   1451 N NE2 . HIS A 1 209 ? 13.864  13.556  -12.140 1.00 8.64  ? 209 HIS A NE2 1 
ATOM   1452 N N   . GLY A 1 210 ? 12.625  14.316  -7.498  1.00 10.23 ? 210 GLY A N   1 
ATOM   1453 C CA  . GLY A 1 210 ? 12.399  15.624  -6.891  1.00 9.93  ? 210 GLY A CA  1 
ATOM   1454 C C   . GLY A 1 210 ? 11.705  16.613  -7.840  1.00 10.33 ? 210 GLY A C   1 
ATOM   1455 O O   . GLY A 1 210 ? 12.095  16.770  -9.003  1.00 10.00 ? 210 GLY A O   1 
ATOM   1456 N N   . THR A 1 211 ? 10.764  17.405  -7.308  1.00 10.22 ? 211 THR A N   1 
ATOM   1457 C CA  . THR A 1 211 ? 10.070  18.372  -8.146  1.00 11.34 ? 211 THR A CA  1 
ATOM   1458 C C   . THR A 1 211 ? 10.993  19.525  -8.560  1.00 11.79 ? 211 THR A C   1 
ATOM   1459 O O   . THR A 1 211 ? 10.717  20.148  -9.565  1.00 13.03 ? 211 THR A O   1 
ATOM   1460 C CB  . THR A 1 211 ? 8.820   18.957  -7.473  1.00 11.81 ? 211 THR A CB  1 
ATOM   1461 O OG1 . THR A 1 211 ? 9.179   19.604  -6.268  1.00 11.58 ? 211 THR A OG1 1 
ATOM   1462 C CG2 . THR A 1 211 ? 7.802   17.926  -7.057  1.00 13.60 ? 211 THR A CG2 1 
ATOM   1463 N N   . ALA A 1 212 ? 12.054  19.816  -7.805  1.00 13.22 ? 212 ALA A N   1 
ATOM   1464 C CA  . ALA A 1 212 ? 12.923  20.965  -8.072  1.00 12.58 ? 212 ALA A CA  1 
ATOM   1465 C C   . ALA A 1 212 ? 14.206  20.563  -8.805  1.00 11.70 ? 212 ALA A C   1 
ATOM   1466 O O   . ALA A 1 212 ? 15.150  21.345  -8.909  1.00 10.63 ? 212 ALA A O   1 
ATOM   1467 C CB  . ALA A 1 212 ? 13.257  21.634  -6.750  1.00 12.95 ? 212 ALA A CB  1 
ATOM   1468 N N   . ASP A 1 213 ? 14.217  19.361  -9.381  1.00 11.24 ? 213 ASP A N   1 
ATOM   1469 C CA  . ASP A 1 213 ? 15.380  18.843  -10.082 1.00 11.19 ? 213 ASP A CA  1 
ATOM   1470 C C   . ASP A 1 213 ? 15.637  19.730  -11.314 1.00 11.93 ? 213 ASP A C   1 
ATOM   1471 O O   . ASP A 1 213 ? 14.786  19.859  -12.189 1.00 11.20 ? 213 ASP A O   1 
ATOM   1472 C CB  . ASP A 1 213 ? 15.112  17.381  -10.480 1.00 10.44 ? 213 ASP A CB  1 
ATOM   1473 C CG  . ASP A 1 213 ? 16.361  16.639  -10.929 1.00 11.04 ? 213 ASP A CG  1 
ATOM   1474 O OD1 . ASP A 1 213 ? 17.230  17.311  -11.539 1.00 9.72  ? 213 ASP A OD1 1 
ATOM   1475 O OD2 . ASP A 1 213 ? 16.438  15.379  -10.679 1.00 11.11 ? 213 ASP A OD2 1 
ATOM   1476 N N   . LYS A 1 214 ? 16.816  20.346  -11.388 1.00 12.27 ? 214 LYS A N   1 
ATOM   1477 C CA  . LYS A 1 214 ? 17.188  21.149  -12.539 1.00 14.06 ? 214 LYS A CA  1 
ATOM   1478 C C   . LYS A 1 214 ? 18.023  20.367  -13.566 1.00 12.26 ? 214 LYS A C   1 
ATOM   1479 O O   . LYS A 1 214 ? 18.313  20.908  -14.643 1.00 12.65 ? 214 LYS A O   1 
ATOM   1480 C CB  . LYS A 1 214 ? 18.014  22.365  -12.086 1.00 16.75 ? 214 LYS A CB  1 
ATOM   1481 C CG  . LYS A 1 214 ? 17.330  23.288  -11.088 1.00 20.44 ? 214 LYS A CG  1 
ATOM   1482 C CD  . LYS A 1 214 ? 16.137  23.989  -11.639 1.00 23.67 ? 214 LYS A CD  1 
ATOM   1483 C CE  . LYS A 1 214 ? 15.509  24.907  -10.604 1.00 29.09 ? 214 LYS A CE  1 
ATOM   1484 N NZ  . LYS A 1 214 ? 14.496  25.789  -11.228 1.00 30.22 ? 214 LYS A NZ  1 
ATOM   1485 N N   . THR A 1 215 ? 18.542  19.195  -13.181 1.00 11.38 ? 215 THR A N   1 
ATOM   1486 C CA  . THR A 1 215 ? 19.485  18.447  -14.005 1.00 12.30 ? 215 THR A CA  1 
ATOM   1487 C C   . THR A 1 215 ? 18.732  17.493  -14.933 1.00 11.94 ? 215 THR A C   1 
ATOM   1488 O O   . THR A 1 215 ? 19.007  17.392  -16.140 1.00 12.07 ? 215 THR A O   1 
ATOM   1489 C CB  . THR A 1 215 ? 20.502  17.724  -13.109 1.00 12.19 ? 215 THR A CB  1 
ATOM   1490 O OG1 . THR A 1 215 ? 21.215  18.699  -12.351 1.00 12.09 ? 215 THR A OG1 1 
ATOM   1491 C CG2 . THR A 1 215 ? 21.519  16.916  -13.878 1.00 11.51 ? 215 THR A CG2 1 
ATOM   1492 N N   . ILE A 1 216 ? 17.819  16.752  -14.309 1.00 10.98 ? 216 ILE A N   1 
ATOM   1493 C CA  . ILE A 1 216 ? 16.890  15.862  -14.958 1.00 10.58 ? 216 ILE A CA  1 
ATOM   1494 C C   . ILE A 1 216 ? 15.500  16.323  -14.511 1.00 10.59 ? 216 ILE A C   1 
ATOM   1495 O O   . ILE A 1 216 ? 14.975  15.902  -13.486 1.00 9.58  ? 216 ILE A O   1 
ATOM   1496 C CB  . ILE A 1 216 ? 17.180  14.380  -14.618 1.00 10.51 ? 216 ILE A CB  1 
ATOM   1497 C CG1 . ILE A 1 216 ? 18.638  13.989  -14.908 1.00 10.77 ? 216 ILE A CG1 1 
ATOM   1498 C CG2 . ILE A 1 216 ? 16.182  13.470  -15.348 1.00 10.01 ? 216 ILE A CG2 1 
ATOM   1499 C CD1 . ILE A 1 216 ? 19.062  14.128  -16.344 1.00 11.52 ? 216 ILE A CD1 1 
ATOM   1500 N N   . PRO A 1 217 ? 14.890  17.323  -15.172 1.00 11.61 ? 217 PRO A N   1 
ATOM   1501 C CA  . PRO A 1 217 ? 13.670  17.939  -14.623 1.00 10.63 ? 217 PRO A CA  1 
ATOM   1502 C C   . PRO A 1 217 ? 12.486  16.977  -14.534 1.00 10.65 ? 217 PRO A C   1 
ATOM   1503 O O   . PRO A 1 217 ? 12.310  16.092  -15.399 1.00 10.25 ? 217 PRO A O   1 
ATOM   1504 C CB  . PRO A 1 217 ? 13.328  19.049  -15.631 1.00 10.98 ? 217 PRO A CB  1 
ATOM   1505 C CG  . PRO A 1 217 ? 14.672  19.349  -16.244 1.00 12.23 ? 217 PRO A CG  1 
ATOM   1506 C CD  . PRO A 1 217 ? 15.364  17.995  -16.389 1.00 11.20 ? 217 PRO A CD  1 
ATOM   1507 N N   . TYR A 1 218 ? 11.717  17.173  -13.454 1.00 11.01 ? 218 TYR A N   1 
ATOM   1508 C CA  . TYR A 1 218 ? 10.451  16.498  -13.215 1.00 10.93 ? 218 TYR A CA  1 
ATOM   1509 C C   . TYR A 1 218 ? 9.576   16.580  -14.475 1.00 12.11 ? 218 TYR A C   1 
ATOM   1510 O O   . TYR A 1 218 ? 8.941   15.596  -14.850 1.00 11.80 ? 218 TYR A O   1 
ATOM   1511 C CB  . TYR A 1 218 ? 9.803   17.061  -11.946 1.00 11.06 ? 218 TYR A CB  1 
ATOM   1512 C CG  . TYR A 1 218 ? 8.705   16.145  -11.422 1.00 10.48 ? 218 TYR A CG  1 
ATOM   1513 C CD1 . TYR A 1 218 ? 9.028   15.036  -10.640 1.00 10.65 ? 218 TYR A CD1 1 
ATOM   1514 C CD2 . TYR A 1 218 ? 7.408   16.252  -11.891 1.00 11.39 ? 218 TYR A CD2 1 
ATOM   1515 C CE1 . TYR A 1 218 ? 8.057   14.147  -10.212 1.00 10.79 ? 218 TYR A CE1 1 
ATOM   1516 C CE2 . TYR A 1 218 ? 6.428   15.357  -11.487 1.00 11.14 ? 218 TYR A CE2 1 
ATOM   1517 C CZ  . TYR A 1 218 ? 6.753   14.316  -10.639 1.00 10.51 ? 218 TYR A CZ  1 
ATOM   1518 O OH  . TYR A 1 218 ? 5.818   13.416  -10.255 1.00 10.06 ? 218 TYR A OH  1 
ATOM   1519 N N   . GLY A 1 219 ? 9.563   17.745  -15.138 1.00 12.07 ? 219 GLY A N   1 
ATOM   1520 C CA  . GLY A 1 219 ? 8.727   17.972  -16.308 1.00 12.28 ? 219 GLY A CA  1 
ATOM   1521 C C   . GLY A 1 219 ? 9.399   17.560  -17.610 1.00 12.65 ? 219 GLY A C   1 
ATOM   1522 O O   . GLY A 1 219 ? 8.788   17.681  -18.682 1.00 13.17 ? 219 GLY A O   1 
ATOM   1523 N N   . GLY A 1 220 ? 10.636  17.035  -17.524 1.00 12.05 ? 220 GLY A N   1 
ATOM   1524 C CA  . GLY A 1 220 ? 11.355  16.633  -18.722 1.00 11.80 ? 220 GLY A CA  1 
ATOM   1525 C C   . GLY A 1 220 ? 11.727  17.838  -19.599 1.00 12.11 ? 220 GLY A C   1 
ATOM   1526 O O   . GLY A 1 220 ? 11.851  18.940  -19.087 1.00 13.34 ? 220 GLY A O   1 
ATOM   1527 N N   . GLY A 1 221 ? 12.007  17.581  -20.873 1.00 11.75 ? 221 GLY A N   1 
ATOM   1528 C CA  . GLY A 1 221 ? 12.290  18.605  -21.865 1.00 13.13 ? 221 GLY A CA  1 
ATOM   1529 C C   . GLY A 1 221 ? 13.618  18.326  -22.549 1.00 13.97 ? 221 GLY A C   1 
ATOM   1530 O O   . GLY A 1 221 ? 14.260  17.299  -22.290 1.00 12.73 ? 221 GLY A O   1 
ATOM   1531 N N   . GLY A 1 222 ? 14.048  19.274  -23.386 1.00 12.84 ? 222 GLY A N   1 
ATOM   1532 C CA  . GLY A 1 222 ? 15.311  19.119  -24.076 1.00 12.63 ? 222 GLY A CA  1 
ATOM   1533 C C   . GLY A 1 222 ? 16.507  19.118  -23.125 1.00 12.43 ? 222 GLY A C   1 
ATOM   1534 O O   . GLY A 1 222 ? 16.562  19.862  -22.153 1.00 14.34 ? 222 GLY A O   1 
ATOM   1535 N N   . ARG A 1 223 ? 17.492  18.284  -23.435 1.00 12.21 ? 223 ARG A N   1 
ATOM   1536 C CA  . ARG A 1 223 ? 18.678  18.189  -22.613 1.00 11.65 ? 223 ARG A CA  1 
ATOM   1537 C C   . ARG A 1 223 ? 19.816  17.600  -23.436 1.00 11.14 ? 223 ARG A C   1 
ATOM   1538 O O   . ARG A 1 223 ? 19.687  16.517  -23.985 1.00 11.08 ? 223 ARG A O   1 
ATOM   1539 C CB  . ARG A 1 223 ? 18.367  17.373  -21.355 1.00 11.29 ? 223 ARG A CB  1 
ATOM   1540 C CG  . ARG A 1 223 ? 19.446  17.446  -20.281 1.00 11.18 ? 223 ARG A CG  1 
ATOM   1541 C CD  . ARG A 1 223 ? 19.719  18.851  -19.761 1.00 11.36 ? 223 ARG A CD  1 
ATOM   1542 N NE  . ARG A 1 223 ? 18.509  19.610  -19.488 1.00 11.53 ? 223 ARG A NE  1 
ATOM   1543 C CZ  . ARG A 1 223 ? 18.177  20.181  -18.347 1.00 11.15 ? 223 ARG A CZ  1 
ATOM   1544 N NH1 . ARG A 1 223 ? 18.961  20.059  -17.296 1.00 11.91 ? 223 ARG A NH1 1 
ATOM   1545 N NH2 . ARG A 1 223 ? 17.052  20.886  -18.267 1.00 12.36 ? 223 ARG A NH2 1 
ATOM   1546 N N   . ARG A 1 224 ? 20.945  18.319  -23.483 1.00 11.35 ? 224 ARG A N   1 
ATOM   1547 C CA  . ARG A 1 224 ? 22.164  17.856  -24.125 1.00 11.99 ? 224 ARG A CA  1 
ATOM   1548 C C   . ARG A 1 224 ? 21.905  17.358  -25.560 1.00 12.04 ? 224 ARG A C   1 
ATOM   1549 O O   . ARG A 1 224 ? 22.560  16.422  -26.014 1.00 11.85 ? 224 ARG A O   1 
ATOM   1550 C CB  . ARG A 1 224 ? 22.792  16.802  -23.208 1.00 11.83 ? 224 ARG A CB  1 
ATOM   1551 C CG  . ARG A 1 224 ? 23.122  17.347  -21.821 1.00 11.92 ? 224 ARG A CG  1 
ATOM   1552 C CD  . ARG A 1 224 ? 23.715  16.366  -20.820 1.00 11.09 ? 224 ARG A CD  1 
ATOM   1553 N NE  . ARG A 1 224 ? 24.812  15.568  -21.377 1.00 11.03 ? 224 ARG A NE  1 
ATOM   1554 C CZ  . ARG A 1 224 ? 24.971  14.251  -21.226 1.00 11.39 ? 224 ARG A CZ  1 
ATOM   1555 N NH1 . ARG A 1 224 ? 24.175  13.542  -20.425 1.00 11.40 ? 224 ARG A NH1 1 
ATOM   1556 N NH2 . ARG A 1 224 ? 25.891  13.629  -21.942 1.00 11.68 ? 224 ARG A NH2 1 
ATOM   1557 N N   . GLY A 1 225 ? 20.966  17.977  -26.289 1.00 11.77 ? 225 GLY A N   1 
ATOM   1558 C CA  . GLY A 1 225 ? 20.744  17.608  -27.675 1.00 14.49 ? 225 GLY A CA  1 
ATOM   1559 C C   . GLY A 1 225 ? 19.682  16.531  -27.869 1.00 15.08 ? 225 GLY A C   1 
ATOM   1560 O O   . GLY A 1 225 ? 19.320  16.240  -29.006 1.00 17.68 ? 225 GLY A O   1 
ATOM   1561 N N   . GLU A 1 226 ? 19.159  15.964  -26.763 1.00 15.25 ? 226 GLU A N   1 
ATOM   1562 C CA  . GLU A 1 226 ? 18.196  14.874  -26.801 1.00 14.95 ? 226 GLU A CA  1 
ATOM   1563 C C   . GLU A 1 226 ? 16.982  15.294  -25.967 1.00 14.35 ? 226 GLU A C   1 
ATOM   1564 O O   . GLU A 1 226 ? 16.859  16.473  -25.615 1.00 14.13 ? 226 GLU A O   1 
ATOM   1565 C CB  . GLU A 1 226 ? 18.886  13.579  -26.357 1.00 16.12 ? 226 GLU A CB  1 
ATOM   1566 C CG  . GLU A 1 226 ? 19.920  13.061  -27.350 1.00 18.93 ? 226 GLU A CG  1 
ATOM   1567 C CD  . GLU A 1 226 ? 20.395  11.627  -27.136 1.00 23.18 ? 226 GLU A CD  1 
ATOM   1568 O OE1 . GLU A 1 226 ? 19.811  10.905  -26.310 1.00 22.81 ? 226 GLU A OE1 1 
ATOM   1569 O OE2 . GLU A 1 226 ? 21.365  11.223  -27.813 1.00 25.36 ? 226 GLU A OE2 1 
ATOM   1570 N N   . CYS A 1 227 ? 16.098  14.335  -25.657 1.00 13.11 ? 227 CYS A N   1 
ATOM   1571 C CA  . CYS A 1 227 ? 14.799  14.617  -25.086 1.00 13.30 ? 227 CYS A CA  1 
ATOM   1572 C C   . CYS A 1 227 ? 14.549  13.754  -23.847 1.00 13.42 ? 227 CYS A C   1 
ATOM   1573 O O   . CYS A 1 227 ? 14.655  12.533  -23.892 1.00 15.49 ? 227 CYS A O   1 
ATOM   1574 C CB  . CYS A 1 227 ? 13.737  14.363  -26.153 1.00 13.91 ? 227 CYS A CB  1 
ATOM   1575 S SG  . CYS A 1 227 ? 12.022  14.655  -25.650 1.00 19.28 ? 227 CYS A SG  1 
ATOM   1576 N N   . LEU A 1 228 ? 14.143  14.386  -22.751 1.00 14.29 ? 228 LEU A N   1 
ATOM   1577 C CA  . LEU A 1 228 ? 13.774  13.644  -21.548 1.00 13.16 ? 228 LEU A CA  1 
ATOM   1578 C C   . LEU A 1 228 ? 12.253  13.671  -21.423 1.00 14.00 ? 228 LEU A C   1 
ATOM   1579 O O   . LEU A 1 228 ? 11.615  14.727  -21.533 1.00 13.91 ? 228 LEU A O   1 
ATOM   1580 C CB  . LEU A 1 228 ? 14.424  14.265  -20.308 1.00 13.13 ? 228 LEU A CB  1 
ATOM   1581 C CG  . LEU A 1 228 ? 15.949  14.223  -20.232 1.00 13.34 ? 228 LEU A CG  1 
ATOM   1582 C CD1 . LEU A 1 228 ? 16.463  15.166  -19.154 1.00 14.07 ? 228 LEU A CD1 1 
ATOM   1583 C CD2 . LEU A 1 228 ? 16.434  12.804  -19.960 1.00 13.37 ? 228 LEU A CD2 1 
ATOM   1584 N N   . PRO A 1 229 ? 11.612  12.535  -21.088 1.00 13.74 ? 229 PRO A N   1 
ATOM   1585 C CA  . PRO A 1 229 ? 10.175  12.562  -20.833 1.00 12.94 ? 229 PRO A CA  1 
ATOM   1586 C C   . PRO A 1 229 ? 9.844   13.231  -19.503 1.00 12.63 ? 229 PRO A C   1 
ATOM   1587 O O   . PRO A 1 229 ? 10.649  13.234  -18.573 1.00 12.72 ? 229 PRO A O   1 
ATOM   1588 C CB  . PRO A 1 229 ? 9.826   11.065  -20.822 1.00 12.66 ? 229 PRO A CB  1 
ATOM   1589 C CG  . PRO A 1 229 ? 11.081  10.440  -20.235 1.00 12.86 ? 229 PRO A CG  1 
ATOM   1590 C CD  . PRO A 1 229 ? 12.226  11.211  -20.868 1.00 12.65 ? 229 PRO A CD  1 
ATOM   1591 N N   . SER A 1 230 ? 8.611   13.731  -19.357 1.00 11.90 ? 230 SER A N   1 
ATOM   1592 C CA  . SER A 1 230 ? 8.154   14.140  -18.038 1.00 11.13 ? 230 SER A CA  1 
ATOM   1593 C C   . SER A 1 230 ? 8.045   12.885  -17.176 1.00 10.41 ? 230 SER A C   1 
ATOM   1594 O O   . SER A 1 230 ? 7.757   11.802  -17.683 1.00 11.09 ? 230 SER A O   1 
ATOM   1595 C CB  . SER A 1 230 ? 6.810   14.837  -18.077 1.00 11.97 ? 230 SER A CB  1 
ATOM   1596 O OG  . SER A 1 230 ? 5.766   13.882  -18.210 1.00 11.53 ? 230 SER A OG  1 
ATOM   1597 N N   . ILE A 1 231 ? 8.270   13.030  -15.880 1.00 10.96 ? 231 ILE A N   1 
ATOM   1598 C CA  . ILE A 1 231 ? 8.222   11.877  -15.004 1.00 10.55 ? 231 ILE A CA  1 
ATOM   1599 C C   . ILE A 1 231 ? 6.795   11.337  -14.907 1.00 10.83 ? 231 ILE A C   1 
ATOM   1600 O O   . ILE A 1 231 ? 6.597   10.129  -14.860 1.00 11.45 ? 231 ILE A O   1 
ATOM   1601 C CB  . ILE A 1 231 ? 8.876   12.181  -13.647 1.00 10.03 ? 231 ILE A CB  1 
ATOM   1602 C CG1 . ILE A 1 231 ? 10.332  12.633  -13.813 1.00 9.61  ? 231 ILE A CG1 1 
ATOM   1603 C CG2 . ILE A 1 231 ? 8.764   10.987  -12.732 1.00 10.21 ? 231 ILE A CG2 1 
ATOM   1604 C CD1 . ILE A 1 231 ? 11.209  11.768  -14.672 1.00 10.53 ? 231 ILE A CD1 1 
ATOM   1605 N N   . PRO A 1 232 ? 5.734   12.147  -14.861 1.00 11.37 ? 232 PRO A N   1 
ATOM   1606 C CA  . PRO A 1 232 ? 4.381   11.559  -14.930 1.00 12.98 ? 232 PRO A CA  1 
ATOM   1607 C C   . PRO A 1 232 ? 4.158   10.751  -16.209 1.00 12.31 ? 232 PRO A C   1 
ATOM   1608 O O   . PRO A 1 232 ? 3.560   9.660   -16.172 1.00 13.33 ? 232 PRO A O   1 
ATOM   1609 C CB  . PRO A 1 232 ? 3.452   12.773  -14.753 1.00 12.49 ? 232 PRO A CB  1 
ATOM   1610 C CG  . PRO A 1 232 ? 4.324   13.802  -14.041 1.00 12.63 ? 232 PRO A CG  1 
ATOM   1611 C CD  . PRO A 1 232 ? 5.727   13.598  -14.598 1.00 11.67 ? 232 PRO A CD  1 
ATOM   1612 N N   . HIS A 1 233 ? 4.702   11.240  -17.327 1.00 11.97 ? 233 HIS A N   1 
ATOM   1613 C CA  . HIS A 1 233 ? 4.641   10.513  -18.585 1.00 12.29 ? 233 HIS A CA  1 
ATOM   1614 C C   . HIS A 1 233 ? 5.342   9.158   -18.470 1.00 11.72 ? 233 HIS A C   1 
ATOM   1615 O O   . HIS A 1 233 ? 4.820   8.141   -18.889 1.00 12.19 ? 233 HIS A O   1 
ATOM   1616 C CB  . HIS A 1 233 ? 5.164   11.357  -19.752 1.00 13.09 ? 233 HIS A CB  1 
ATOM   1617 C CG  . HIS A 1 233 ? 5.177   10.668  -21.076 1.00 12.56 ? 233 HIS A CG  1 
ATOM   1618 N ND1 . HIS A 1 233 ? 4.126   9.906   -21.545 1.00 11.92 ? 233 HIS A ND1 1 
ATOM   1619 C CD2 . HIS A 1 233 ? 6.145   10.620  -22.026 1.00 13.35 ? 233 HIS A CD2 1 
ATOM   1620 C CE1 . HIS A 1 233 ? 4.451   9.420   -22.739 1.00 12.83 ? 233 HIS A CE1 1 
ATOM   1621 N NE2 . HIS A 1 233 ? 5.677   9.854   -23.062 1.00 13.00 ? 233 HIS A NE2 1 
ATOM   1622 N N   . PHE A 1 234 ? 6.558   9.141   -17.935 1.00 11.30 ? 234 PHE A N   1 
ATOM   1623 C CA  . PHE A 1 234 ? 7.279   7.915   -17.680 1.00 10.46 ? 234 PHE A CA  1 
ATOM   1624 C C   . PHE A 1 234 ? 6.441   6.936   -16.861 1.00 11.72 ? 234 PHE A C   1 
ATOM   1625 O O   . PHE A 1 234 ? 6.392   5.748   -17.208 1.00 11.35 ? 234 PHE A O   1 
ATOM   1626 C CB  . PHE A 1 234 ? 8.570   8.238   -16.925 1.00 9.81  ? 234 PHE A CB  1 
ATOM   1627 C CG  . PHE A 1 234 ? 9.405   7.068   -16.499 1.00 9.58  ? 234 PHE A CG  1 
ATOM   1628 C CD1 . PHE A 1 234 ? 10.274  6.453   -17.398 1.00 9.59  ? 234 PHE A CD1 1 
ATOM   1629 C CD2 . PHE A 1 234 ? 9.315   6.573   -15.214 1.00 9.26  ? 234 PHE A CD2 1 
ATOM   1630 C CE1 . PHE A 1 234 ? 11.059  5.390   -16.983 1.00 9.30  ? 234 PHE A CE1 1 
ATOM   1631 C CE2 . PHE A 1 234 ? 10.100  5.512   -14.794 1.00 9.43  ? 234 PHE A CE2 1 
ATOM   1632 C CZ  . PHE A 1 234 ? 10.978  4.932   -15.680 1.00 9.01  ? 234 PHE A CZ  1 
ATOM   1633 N N   . VAL A 1 235 ? 5.869   7.444   -15.755 1.00 11.91 ? 235 VAL A N   1 
ATOM   1634 C CA  . VAL A 1 235 ? 5.125   6.626   -14.809 1.00 13.24 ? 235 VAL A CA  1 
ATOM   1635 C C   . VAL A 1 235 ? 3.891   6.040   -15.491 1.00 14.13 ? 235 VAL A C   1 
ATOM   1636 O O   . VAL A 1 235 ? 3.627   4.864   -15.335 1.00 13.63 ? 235 VAL A O   1 
ATOM   1637 C CB  . VAL A 1 235 ? 4.777   7.419   -13.527 1.00 13.45 ? 235 VAL A CB  1 
ATOM   1638 C CG1 . VAL A 1 235 ? 3.775   6.713   -12.625 1.00 14.81 ? 235 VAL A CG1 1 
ATOM   1639 C CG2 . VAL A 1 235 ? 6.040   7.700   -12.736 1.00 13.82 ? 235 VAL A CG2 1 
ATOM   1640 N N   . ARG A 1 236 ? 3.145   6.882   -16.189 1.00 15.24 ? 236 ARG A N   1 
ATOM   1641 C CA  . ARG A 1 236 ? 1.961   6.482   -16.921 1.00 16.95 ? 236 ARG A CA  1 
ATOM   1642 C C   . ARG A 1 236 ? 2.278   5.406   -17.959 1.00 15.34 ? 236 ARG A C   1 
ATOM   1643 O O   . ARG A 1 236 ? 1.507   4.455   -18.103 1.00 14.26 ? 236 ARG A O   1 
ATOM   1644 C CB  . ARG A 1 236 ? 1.313   7.680   -17.619 1.00 19.49 ? 236 ARG A CB  1 
ATOM   1645 C CG  . ARG A 1 236 ? 0.538   8.620   -16.709 1.00 25.60 ? 236 ARG A CG  1 
ATOM   1646 C CD  . ARG A 1 236 ? -0.292  9.616   -17.535 1.00 30.16 ? 236 ARG A CD  1 
ATOM   1647 N NE  . ARG A 1 236 ? 0.489   10.404  -18.502 1.00 35.18 ? 236 ARG A NE  1 
ATOM   1648 C CZ  . ARG A 1 236 ? 0.932   11.648  -18.294 1.00 36.45 ? 236 ARG A CZ  1 
ATOM   1649 N NH1 . ARG A 1 236 ? 0.704   12.252  -17.133 1.00 35.76 ? 236 ARG A NH1 1 
ATOM   1650 N NH2 . ARG A 1 236 ? 1.607   12.275  -19.249 1.00 38.06 ? 236 ARG A NH2 1 
ATOM   1651 N N   . GLU A 1 237 ? 3.364   5.571   -18.725 1.00 14.76 ? 237 GLU A N   1 
ATOM   1652 C CA  . GLU A 1 237 ? 3.710   4.582   -19.737 1.00 15.56 ? 237 GLU A CA  1 
ATOM   1653 C C   . GLU A 1 237 ? 4.019   3.206   -19.116 1.00 15.87 ? 237 GLU A C   1 
ATOM   1654 O O   . GLU A 1 237 ? 3.655   2.173   -19.687 1.00 14.82 ? 237 GLU A O   1 
ATOM   1655 C CB  . GLU A 1 237 ? 4.859   5.070   -20.618 1.00 17.31 ? 237 GLU A CB  1 
ATOM   1656 C CG  . GLU A 1 237 ? 4.493   6.273   -21.458 1.00 19.69 ? 237 GLU A CG  1 
ATOM   1657 C CD  . GLU A 1 237 ? 3.413   5.991   -22.478 1.00 23.48 ? 237 GLU A CD  1 
ATOM   1658 O OE1 . GLU A 1 237 ? 3.674   5.172   -23.310 1.00 28.54 ? 237 GLU A OE1 1 
ATOM   1659 O OE2 . GLU A 1 237 ? 2.306   6.524   -22.367 1.00 30.33 ? 237 GLU A OE2 1 
ATOM   1660 N N   . TRP A 1 238 ? 4.677   3.160   -17.946 1.00 13.06 ? 238 TRP A N   1 
ATOM   1661 C CA  . TRP A 1 238 ? 4.875   1.880   -17.288 1.00 13.29 ? 238 TRP A CA  1 
ATOM   1662 C C   . TRP A 1 238 ? 3.539   1.280   -16.840 1.00 15.60 ? 238 TRP A C   1 
ATOM   1663 O O   . TRP A 1 238 ? 3.316   0.085   -17.013 1.00 17.03 ? 238 TRP A O   1 
ATOM   1664 C CB  . TRP A 1 238 ? 5.848   2.001   -16.109 1.00 12.75 ? 238 TRP A CB  1 
ATOM   1665 C CG  . TRP A 1 238 ? 7.274   1.821   -16.542 1.00 12.64 ? 238 TRP A CG  1 
ATOM   1666 C CD1 . TRP A 1 238 ? 8.286   2.738   -16.517 1.00 13.52 ? 238 TRP A CD1 1 
ATOM   1667 C CD2 . TRP A 1 238 ? 7.837   0.626   -17.102 1.00 12.50 ? 238 TRP A CD2 1 
ATOM   1668 N NE1 . TRP A 1 238 ? 9.453   2.185   -16.959 1.00 12.75 ? 238 TRP A NE1 1 
ATOM   1669 C CE2 . TRP A 1 238 ? 9.206   0.897   -17.347 1.00 12.55 ? 238 TRP A CE2 1 
ATOM   1670 C CE3 . TRP A 1 238 ? 7.335   -0.649  -17.404 1.00 13.68 ? 238 TRP A CE3 1 
ATOM   1671 C CZ2 . TRP A 1 238 ? 10.069  -0.066  -17.859 1.00 12.46 ? 238 TRP A CZ2 1 
ATOM   1672 C CZ3 . TRP A 1 238 ? 8.204   -1.591  -17.939 1.00 13.64 ? 238 TRP A CZ3 1 
ATOM   1673 C CH2 . TRP A 1 238 ? 9.557   -1.313  -18.131 1.00 11.76 ? 238 TRP A CH2 1 
ATOM   1674 N N   . SER A 1 239 ? 2.680   2.102   -16.239 1.00 15.38 ? 239 SER A N   1 
ATOM   1675 C CA  . SER A 1 239 ? 1.459   1.605   -15.637 1.00 19.27 ? 239 SER A CA  1 
ATOM   1676 C C   . SER A 1 239 ? 0.488   1.144   -16.725 1.00 21.51 ? 239 SER A C   1 
ATOM   1677 O O   . SER A 1 239 ? -0.302  0.221   -16.499 1.00 19.35 ? 239 SER A O   1 
ATOM   1678 C CB  . SER A 1 239 ? 0.841   2.657   -14.748 1.00 21.52 ? 239 SER A CB  1 
ATOM   1679 O OG  . SER A 1 239 ? 0.438   3.793   -15.515 1.00 26.42 ? 239 SER A OG  1 
ATOM   1680 N N   . LYS A 1 240 ? 0.549   1.786   -17.897 1.00 21.87 ? 240 LYS A N   1 
ATOM   1681 C CA  . LYS A 1 240 ? -0.307  1.419   -19.017 1.00 27.65 ? 240 LYS A CA  1 
ATOM   1682 C C   . LYS A 1 240 ? -0.118  -0.052  -19.366 1.00 32.24 ? 240 LYS A C   1 
ATOM   1683 O O   . LYS A 1 240 ? -1.010  -0.633  -19.962 1.00 33.82 ? 240 LYS A O   1 
ATOM   1684 C CB  . LYS A 1 240 ? -0.020  2.244   -20.280 1.00 29.90 ? 240 LYS A CB  1 
ATOM   1685 C CG  . LYS A 1 240 ? -0.799  3.546   -20.391 1.00 37.64 ? 240 LYS A CG  1 
ATOM   1686 C CD  . LYS A 1 240 ? -0.529  4.287   -21.690 1.00 42.28 ? 240 LYS A CD  1 
ATOM   1687 C CE  . LYS A 1 240 ? -1.159  5.665   -21.731 1.00 47.16 ? 240 LYS A CE  1 
ATOM   1688 N NZ  . LYS A 1 240 ? -0.604  6.481   -22.842 1.00 47.25 ? 240 LYS A NZ  1 
ATOM   1689 N N   . ARG A 1 241 ? 1.038   -0.643  -19.035 1.00 34.79 ? 241 ARG A N   1 
ATOM   1690 C CA  . ARG A 1 241 ? 1.321   -2.017  -19.427 1.00 37.26 ? 241 ARG A CA  1 
ATOM   1691 C C   . ARG A 1 241 ? 0.598   -3.010  -18.513 1.00 38.62 ? 241 ARG A C   1 
ATOM   1692 O O   . ARG A 1 241 ? 0.386   -4.152  -18.888 1.00 44.70 ? 241 ARG A O   1 
ATOM   1693 C CB  . ARG A 1 241 ? 2.827   -2.252  -19.467 1.00 36.73 ? 241 ARG A CB  1 
ATOM   1694 C CG  . ARG A 1 241 ? 3.515   -1.450  -20.561 1.00 43.85 ? 241 ARG A CG  1 
ATOM   1695 C CD  . ARG A 1 241 ? 5.012   -1.331  -20.309 1.00 45.55 ? 241 ARG A CD  1 
ATOM   1696 N NE  . ARG A 1 241 ? 5.708   -0.376  -21.166 1.00 46.83 ? 241 ARG A NE  1 
ATOM   1697 C CZ  . ARG A 1 241 ? 6.016   -0.568  -22.437 1.00 49.42 ? 241 ARG A CZ  1 
ATOM   1698 N NH1 . ARG A 1 241 ? 5.759   -1.727  -23.022 1.00 55.77 ? 241 ARG A NH1 1 
ATOM   1699 N NH2 . ARG A 1 241 ? 6.592   0.406   -23.118 1.00 52.67 ? 241 ARG A NH2 1 
ATOM   1700 N N   . LEU A 1 242 ? 0.174   -2.575  -17.323 1.00 36.39 ? 242 LEU A N   1 
ATOM   1701 C CA  . LEU A 1 242 ? -0.544  -3.442  -16.401 1.00 36.60 ? 242 LEU A CA  1 
ATOM   1702 C C   . LEU A 1 242 ? -1.946  -3.674  -16.945 1.00 39.50 ? 242 LEU A C   1 
ATOM   1703 O O   . LEU A 1 242 ? -2.633  -4.567  -16.460 1.00 41.97 ? 242 LEU A O   1 
ATOM   1704 C CB  . LEU A 1 242 ? -0.632  -2.814  -15.001 1.00 32.09 ? 242 LEU A CB  1 
ATOM   1705 C CG  . LEU A 1 242 ? 0.696   -2.388  -14.389 1.00 29.88 ? 242 LEU A CG  1 
ATOM   1706 C CD1 . LEU A 1 242 ? 0.454   -1.650  -13.074 1.00 29.69 ? 242 LEU A CD1 1 
ATOM   1707 C CD2 . LEU A 1 242 ? 1.628   -3.594  -14.199 1.00 30.33 ? 242 LEU A CD2 1 
ATOM   1708 N N   . GLY A 1 243 ? -2.358  -2.814  -17.886 1.00 34.91 ? 243 GLY A N   1 
ATOM   1709 C CA  . GLY A 1 243 ? -3.419  -3.160  -18.800 1.00 37.89 ? 243 GLY A CA  1 
ATOM   1710 C C   . GLY A 1 243 ? -4.733  -3.308  -18.048 1.00 40.37 ? 243 GLY A C   1 
ATOM   1711 O O   . GLY A 1 243 ? -5.033  -2.467  -17.199 1.00 38.39 ? 243 GLY A O   1 
ATOM   1712 N N   . TYR A 1 244 ? -5.463  -4.409  -18.328 1.00 46.53 ? 244 TYR A N   1 
ATOM   1713 C CA  . TYR A 1 244 ? -6.823  -4.606  -17.829 1.00 48.21 ? 244 TYR A CA  1 
ATOM   1714 C C   . TYR A 1 244 ? -6.818  -4.679  -16.298 1.00 46.14 ? 244 TYR A C   1 
ATOM   1715 O O   . TYR A 1 244 ? -5.991  -5.363  -15.688 1.00 48.13 ? 244 TYR A O   1 
ATOM   1716 C CB  . TYR A 1 244 ? -7.525  -5.835  -18.438 1.00 48.78 ? 244 TYR A CB  1 
ATOM   1717 C CG  . TYR A 1 244 ? -8.852  -6.190  -17.771 1.00 50.24 ? 244 TYR A CG  1 
ATOM   1718 C CD1 . TYR A 1 244 ? -8.885  -6.962  -16.609 1.00 48.16 ? 244 TYR A CD1 1 
ATOM   1719 C CD2 . TYR A 1 244 ? -10.068 -5.704  -18.258 1.00 52.25 ? 244 TYR A CD2 1 
ATOM   1720 C CE1 . TYR A 1 244 ? -10.079 -7.272  -15.974 1.00 52.52 ? 244 TYR A CE1 1 
ATOM   1721 C CE2 . TYR A 1 244 ? -11.272 -6.007  -17.630 1.00 55.45 ? 244 TYR A CE2 1 
ATOM   1722 C CZ  . TYR A 1 244 ? -11.278 -6.797  -16.487 1.00 57.91 ? 244 TYR A CZ  1 
ATOM   1723 O OH  . TYR A 1 244 ? -12.445 -7.106  -15.848 1.00 55.26 ? 244 TYR A OH  1 
ATOM   1724 N N   . GLY A 1 245 ? -7.785  -3.974  -15.691 1.00 41.90 ? 245 GLY A N   1 
ATOM   1725 C CA  . GLY A 1 245 ? -7.927  -3.928  -14.247 1.00 35.98 ? 245 GLY A CA  1 
ATOM   1726 C C   . GLY A 1 245 ? -7.074  -2.829  -13.608 1.00 33.86 ? 245 GLY A C   1 
ATOM   1727 O O   . GLY A 1 245 ? -6.997  -2.789  -12.386 1.00 31.60 ? 245 GLY A O   1 
ATOM   1728 N N   . LEU A 1 246 ? -6.456  -1.940  -14.413 1.00 29.54 ? 246 LEU A N   1 
ATOM   1729 C CA  . LEU A 1 246 ? -5.541  -0.914  -13.908 1.00 30.66 ? 246 LEU A CA  1 
ATOM   1730 C C   . LEU A 1 246 ? -6.273  0.041   -12.959 1.00 32.49 ? 246 LEU A C   1 
ATOM   1731 O O   . LEU A 1 246 ? -7.280  0.621   -13.349 1.00 29.76 ? 246 LEU A O   1 
ATOM   1732 C CB  . LEU A 1 246 ? -4.925  -0.161  -15.098 1.00 31.68 ? 246 LEU A CB  1 
ATOM   1733 C CG  . LEU A 1 246 ? -4.079  1.078   -14.792 1.00 30.06 ? 246 LEU A CG  1 
ATOM   1734 C CD1 . LEU A 1 246 ? -2.930  0.767   -13.847 1.00 31.78 ? 246 LEU A CD1 1 
ATOM   1735 C CD2 . LEU A 1 246 ? -3.568  1.710   -16.077 1.00 33.83 ? 246 LEU A CD2 1 
ATOM   1736 N N   . HIS A 1 247 ? -5.758  0.198   -11.725 1.00 33.28 ? 247 HIS A N   1 
ATOM   1737 C CA  . HIS A 1 247 ? -6.193  1.247   -10.807 1.00 37.01 ? 247 HIS A CA  1 
ATOM   1738 C C   . HIS A 1 247 ? -4.988  1.909   -10.120 1.00 32.08 ? 247 HIS A C   1 
ATOM   1739 O O   . HIS A 1 247 ? -3.870  1.395   -10.154 1.00 29.32 ? 247 HIS A O   1 
ATOM   1740 C CB  . HIS A 1 247 ? -7.252  0.766   -9.795  1.00 45.59 ? 247 HIS A CB  1 
ATOM   1741 C CG  . HIS A 1 247 ? -7.473  -0.708  -9.654  1.00 60.02 ? 247 HIS A CG  1 
ATOM   1742 N ND1 . HIS A 1 247 ? -6.644  -1.589  -8.987  1.00 70.92 ? 247 HIS A ND1 1 
ATOM   1743 C CD2 . HIS A 1 247 ? -8.528  -1.444  -10.078 1.00 68.68 ? 247 HIS A CD2 1 
ATOM   1744 C CE1 . HIS A 1 247 ? -7.166  -2.817  -9.043  1.00 72.57 ? 247 HIS A CE1 1 
ATOM   1745 N NE2 . HIS A 1 247 ? -8.309  -2.751  -9.701  1.00 71.35 ? 247 HIS A NE2 1 
ATOM   1746 N N   . ASN A 1 248 ? -5.221  3.077   -9.514  1.00 29.16 ? 248 ASN A N   1 
ATOM   1747 C CA  . ASN A 1 248 ? -4.167  3.778   -8.794  1.00 28.99 ? 248 ASN A CA  1 
ATOM   1748 C C   . ASN A 1 248 ? -4.719  4.390   -7.511  1.00 30.45 ? 248 ASN A C   1 
ATOM   1749 O O   . ASN A 1 248 ? -5.926  4.584   -7.351  1.00 24.30 ? 248 ASN A O   1 
ATOM   1750 C CB  . ASN A 1 248 ? -3.508  4.878   -9.628  1.00 26.07 ? 248 ASN A CB  1 
ATOM   1751 C CG  . ASN A 1 248 ? -4.485  5.972   -9.966  1.00 29.29 ? 248 ASN A CG  1 
ATOM   1752 O OD1 . ASN A 1 248 ? -5.017  6.615   -9.056  1.00 28.70 ? 248 ASN A OD1 1 
ATOM   1753 N ND2 . ASN A 1 248 ? -4.792  6.098   -11.245 1.00 27.55 ? 248 ASN A ND2 1 
ATOM   1754 N N   . THR A 1 249 ? -3.791  4.655   -6.600  1.00 26.46 ? 249 THR A N   1 
ATOM   1755 C CA  . THR A 1 249 ? -4.055  5.431   -5.412  1.00 24.71 ? 249 THR A CA  1 
ATOM   1756 C C   . THR A 1 249 ? -2.968  6.492   -5.304  1.00 24.56 ? 249 THR A C   1 
ATOM   1757 O O   . THR A 1 249 ? -1.850  6.342   -5.834  1.00 22.31 ? 249 THR A O   1 
ATOM   1758 C CB  . THR A 1 249 ? -4.064  4.542   -4.171  1.00 27.88 ? 249 THR A CB  1 
ATOM   1759 O OG1 . THR A 1 249 ? -2.813  3.867   -4.225  1.00 31.10 ? 249 THR A OG1 1 
ATOM   1760 C CG2 . THR A 1 249 ? -5.201  3.544   -4.118  1.00 32.52 ? 249 THR A CG2 1 
ATOM   1761 N N   . THR A 1 250 ? -3.311  7.567   -4.599  1.00 20.97 ? 250 THR A N   1 
ATOM   1762 C CA  . THR A 1 250 ? -2.347  8.561   -4.186  1.00 18.70 ? 250 THR A CA  1 
ATOM   1763 C C   . THR A 1 250 ? -2.387  8.634   -2.662  1.00 18.38 ? 250 THR A C   1 
ATOM   1764 O O   . THR A 1 250 ? -3.467  8.592   -2.105  1.00 15.72 ? 250 THR A O   1 
ATOM   1765 C CB  . THR A 1 250 ? -2.665  9.897   -4.854  1.00 19.42 ? 250 THR A CB  1 
ATOM   1766 O OG1 . THR A 1 250 ? -2.625  9.716   -6.264  1.00 17.88 ? 250 THR A OG1 1 
ATOM   1767 C CG2 . THR A 1 250 ? -1.697  10.975  -4.445  1.00 19.84 ? 250 THR A CG2 1 
ATOM   1768 N N   . LYS A 1 251 ? -1.225  8.756   -2.012  1.00 17.08 ? 251 LYS A N   1 
ATOM   1769 C CA  . LYS A 1 251 ? -1.139  9.060   -0.603  1.00 17.01 ? 251 LYS A CA  1 
ATOM   1770 C C   . LYS A 1 251 ? -0.299  10.311  -0.394  1.00 16.16 ? 251 LYS A C   1 
ATOM   1771 O O   . LYS A 1 251 ? 0.703   10.517  -1.079  1.00 13.31 ? 251 LYS A O   1 
ATOM   1772 C CB  . LYS A 1 251 ? -0.430  7.970   0.196   1.00 21.49 ? 251 LYS A CB  1 
ATOM   1773 C CG  . LYS A 1 251 ? -1.079  6.600   0.246   1.00 27.91 ? 251 LYS A CG  1 
ATOM   1774 C CD  . LYS A 1 251 ? -0.186  5.624   1.035   1.00 34.25 ? 251 LYS A CD  1 
ATOM   1775 C CE  . LYS A 1 251 ? -0.759  4.234   1.167   1.00 40.15 ? 251 LYS A CE  1 
ATOM   1776 N NZ  . LYS A 1 251 ? -1.220  3.730   -0.148  1.00 40.70 ? 251 LYS A NZ  1 
ATOM   1777 N N   . GLU A 1 252 ? -0.727  11.141  0.564   1.00 14.17 ? 252 GLU A N   1 
ATOM   1778 C CA  . GLU A 1 252 ? 0.053   12.295  1.012   1.00 14.28 ? 252 GLU A CA  1 
ATOM   1779 C C   . GLU A 1 252 ? 0.922   11.824  2.163   1.00 14.25 ? 252 GLU A C   1 
ATOM   1780 O O   . GLU A 1 252 ? 0.405   11.230  3.096   1.00 14.19 ? 252 GLU A O   1 
ATOM   1781 C CB  . GLU A 1 252 ? -0.858  13.435  1.471   1.00 14.25 ? 252 GLU A CB  1 
ATOM   1782 C CG  . GLU A 1 252 ? -1.719  13.984  0.355   1.00 13.91 ? 252 GLU A CG  1 
ATOM   1783 C CD  . GLU A 1 252 ? -0.983  14.669  -0.775  1.00 14.77 ? 252 GLU A CD  1 
ATOM   1784 O OE1 . GLU A 1 252 ? 0.174   15.085  -0.552  1.00 13.43 ? 252 GLU A OE1 1 
ATOM   1785 O OE2 . GLU A 1 252 ? -1.567  14.789  -1.884  1.00 15.99 ? 252 GLU A OE2 1 
ATOM   1786 N N   . LEU A 1 253 ? 2.242   11.959  2.031   1.00 12.78 ? 253 LEU A N   1 
ATOM   1787 C CA  . LEU A 1 253 ? 3.146   11.577  3.105   1.00 13.32 ? 253 LEU A CA  1 
ATOM   1788 C C   . LEU A 1 253 ? 3.900   12.820  3.585   1.00 12.23 ? 253 LEU A C   1 
ATOM   1789 O O   . LEU A 1 253 ? 3.982   13.813  2.862   1.00 11.64 ? 253 LEU A O   1 
ATOM   1790 C CB  . LEU A 1 253 ? 4.105   10.503  2.577   1.00 14.09 ? 253 LEU A CB  1 
ATOM   1791 C CG  . LEU A 1 253 ? 3.492   9.283   1.899   1.00 16.96 ? 253 LEU A CG  1 
ATOM   1792 C CD1 . LEU A 1 253 ? 4.591   8.324   1.474   1.00 18.08 ? 253 LEU A CD1 1 
ATOM   1793 C CD2 . LEU A 1 253 ? 2.521   8.562   2.823   1.00 20.40 ? 253 LEU A CD2 1 
ATOM   1794 N N   . TYR A 1 254 ? 4.452   12.768  4.809   1.00 13.22 ? 254 TYR A N   1 
ATOM   1795 C CA  . TYR A 1 254 ? 5.274   13.845  5.382   1.00 14.12 ? 254 TYR A CA  1 
ATOM   1796 C C   . TYR A 1 254 ? 4.561   15.188  5.307   1.00 15.01 ? 254 TYR A C   1 
ATOM   1797 O O   . TYR A 1 254 ? 5.031   16.171  4.716   1.00 14.95 ? 254 TYR A O   1 
ATOM   1798 C CB  . TYR A 1 254 ? 6.646   13.865  4.710   1.00 15.36 ? 254 TYR A CB  1 
ATOM   1799 C CG  . TYR A 1 254 ? 7.335   12.556  5.013   1.00 15.69 ? 254 TYR A CG  1 
ATOM   1800 C CD1 . TYR A 1 254 ? 7.819   12.311  6.284   1.00 17.51 ? 254 TYR A CD1 1 
ATOM   1801 C CD2 . TYR A 1 254 ? 7.385   11.534  4.073   1.00 15.80 ? 254 TYR A CD2 1 
ATOM   1802 C CE1 . TYR A 1 254 ? 8.401   11.099  6.607   1.00 18.33 ? 254 TYR A CE1 1 
ATOM   1803 C CE2 . TYR A 1 254 ? 7.938   10.311  4.389   1.00 17.96 ? 254 TYR A CE2 1 
ATOM   1804 C CZ  . TYR A 1 254 ? 8.476   10.103  5.652   1.00 18.99 ? 254 TYR A CZ  1 
ATOM   1805 O OH  . TYR A 1 254 ? 9.036   8.898   5.983   1.00 19.62 ? 254 TYR A OH  1 
ATOM   1806 N N   . ASP A 1 255 ? 3.363   15.187  5.880   1.00 15.25 ? 255 ASP A N   1 
ATOM   1807 C CA  . ASP A 1 255 ? 2.523   16.378  5.889   1.00 16.56 ? 255 ASP A CA  1 
ATOM   1808 C C   . ASP A 1 255 ? 2.237   16.845  4.468   1.00 15.63 ? 255 ASP A C   1 
ATOM   1809 O O   . ASP A 1 255 ? 2.050   18.037  4.220   1.00 15.93 ? 255 ASP A O   1 
ATOM   1810 C CB  . ASP A 1 255 ? 3.166   17.505  6.699   1.00 17.31 ? 255 ASP A CB  1 
ATOM   1811 C CG  . ASP A 1 255 ? 3.274   17.164  8.175   1.00 20.26 ? 255 ASP A CG  1 
ATOM   1812 O OD1 . ASP A 1 255 ? 2.348   16.518  8.707   1.00 18.09 ? 255 ASP A OD1 1 
ATOM   1813 O OD2 . ASP A 1 255 ? 4.321   17.482  8.746   1.00 24.63 ? 255 ASP A OD2 1 
ATOM   1814 N N   . GLY A 1 256 ? 2.182   15.893  3.537   1.00 13.85 ? 256 GLY A N   1 
ATOM   1815 C CA  . GLY A 1 256 ? 1.872   16.214  2.158   1.00 13.45 ? 256 GLY A CA  1 
ATOM   1816 C C   . GLY A 1 256 ? 2.997   16.894  1.372   1.00 12.82 ? 256 GLY A C   1 
ATOM   1817 O O   . GLY A 1 256 ? 2.734   17.443  0.324   1.00 12.45 ? 256 GLY A O   1 
ATOM   1818 N N   . ASN A 1 257 ? 4.237   16.850  1.857   1.00 13.63 ? 257 ASN A N   1 
ATOM   1819 C CA  . ASN A 1 257 ? 5.394   17.290  1.099   1.00 13.86 ? 257 ASN A CA  1 
ATOM   1820 C C   . ASN A 1 257 ? 5.835   16.207  0.115   1.00 15.00 ? 257 ASN A C   1 
ATOM   1821 O O   . ASN A 1 257 ? 6.559   16.529  -0.852  1.00 13.17 ? 257 ASN A O   1 
ATOM   1822 C CB  . ASN A 1 257 ? 6.568   17.683  2.015   1.00 14.43 ? 257 ASN A CB  1 
ATOM   1823 C CG  . ASN A 1 257 ? 6.316   18.972  2.769   1.00 14.25 ? 257 ASN A CG  1 
ATOM   1824 O OD1 . ASN A 1 257 ? 6.264   20.039  2.183   1.00 16.63 ? 257 ASN A OD1 1 
ATOM   1825 N ND2 . ASN A 1 257 ? 6.147   18.882  4.067   1.00 15.60 ? 257 ASN A ND2 1 
ATOM   1826 N N   . VAL A 1 258 ? 5.369   14.943  0.342   1.00 12.57 ? 258 VAL A N   1 
ATOM   1827 C CA  . VAL A 1 258 ? 5.662   13.828  -0.555  1.00 11.03 ? 258 VAL A CA  1 
ATOM   1828 C C   . VAL A 1 258 ? 4.351   13.212  -1.016  1.00 10.36 ? 258 VAL A C   1 
ATOM   1829 O O   . VAL A 1 258 ? 3.447   13.051  -0.217  1.00 9.81  ? 258 VAL A O   1 
ATOM   1830 C CB  . VAL A 1 258 ? 6.512   12.761  0.163   1.00 11.41 ? 258 VAL A CB  1 
ATOM   1831 C CG1 . VAL A 1 258 ? 6.649   11.471  -0.629  1.00 11.33 ? 258 VAL A CG1 1 
ATOM   1832 C CG2 . VAL A 1 258 ? 7.868   13.306  0.557   1.00 12.06 ? 258 VAL A CG2 1 
ATOM   1833 N N   . GLN A 1 259 ? 4.257   12.854  -2.296  1.00 10.34 ? 259 GLN A N   1 
ATOM   1834 C CA  . GLN A 1 259 ? 3.112   12.110  -2.787  1.00 10.59 ? 259 GLN A CA  1 
ATOM   1835 C C   . GLN A 1 259 ? 3.640   10.758  -3.253  1.00 11.19 ? 259 GLN A C   1 
ATOM   1836 O O   . GLN A 1 259 ? 4.662   10.686  -3.954  1.00 11.31 ? 259 GLN A O   1 
ATOM   1837 C CB  . GLN A 1 259 ? 2.376   12.805  -3.931  1.00 10.97 ? 259 GLN A CB  1 
ATOM   1838 C CG  . GLN A 1 259 ? 1.697   14.139  -3.602  1.00 11.71 ? 259 GLN A CG  1 
ATOM   1839 C CD  . GLN A 1 259 ? 2.678   15.250  -3.327  1.00 12.60 ? 259 GLN A CD  1 
ATOM   1840 O OE1 . GLN A 1 259 ? 3.615   15.495  -4.096  1.00 13.48 ? 259 GLN A OE1 1 
ATOM   1841 N NE2 . GLN A 1 259 ? 2.470   15.944  -2.222  1.00 12.74 ? 259 GLN A NE2 1 
ATOM   1842 N N   . GLU A 1 260 ? 2.917   9.719   -2.857  1.00 10.69 ? 260 GLU A N   1 
ATOM   1843 C CA  . GLU A 1 260 ? 3.197   8.365   -3.280  1.00 11.79 ? 260 GLU A CA  1 
ATOM   1844 C C   . GLU A 1 260 ? 2.069   7.902   -4.196  1.00 12.34 ? 260 GLU A C   1 
ATOM   1845 O O   . GLU A 1 260 ? 0.903   7.829   -3.783  1.00 14.66 ? 260 GLU A O   1 
ATOM   1846 C CB  . GLU A 1 260 ? 3.330   7.417   -2.092  1.00 12.42 ? 260 GLU A CB  1 
ATOM   1847 C CG  . GLU A 1 260 ? 3.547   5.971   -2.553  1.00 13.47 ? 260 GLU A CG  1 
ATOM   1848 C CD  . GLU A 1 260 ? 3.471   4.886   -1.500  1.00 15.68 ? 260 GLU A CD  1 
ATOM   1849 O OE1 . GLU A 1 260 ? 3.284   5.209   -0.317  1.00 14.96 ? 260 GLU A OE1 1 
ATOM   1850 O OE2 . GLU A 1 260 ? 3.714   3.714   -1.878  1.00 16.75 ? 260 GLU A OE2 1 
ATOM   1851 N N   . TYR A 1 261 ? 2.416   7.602   -5.442  1.00 11.03 ? 261 TYR A N   1 
ATOM   1852 C CA  . TYR A 1 261 ? 1.435   7.113   -6.387  1.00 11.33 ? 261 TYR A CA  1 
ATOM   1853 C C   . TYR A 1 261 ? 1.677   5.631   -6.645  1.00 12.71 ? 261 TYR A C   1 
ATOM   1854 O O   . TYR A 1 261 ? 2.798   5.228   -6.950  1.00 11.31 ? 261 TYR A O   1 
ATOM   1855 C CB  . TYR A 1 261 ? 1.496   7.863   -7.718  1.00 11.86 ? 261 TYR A CB  1 
ATOM   1856 C CG  . TYR A 1 261 ? 1.471   9.378   -7.607  1.00 11.94 ? 261 TYR A CG  1 
ATOM   1857 C CD1 . TYR A 1 261 ? 2.635   10.110  -7.389  1.00 12.38 ? 261 TYR A CD1 1 
ATOM   1858 C CD2 . TYR A 1 261 ? 0.284   10.074  -7.740  1.00 12.53 ? 261 TYR A CD2 1 
ATOM   1859 C CE1 . TYR A 1 261 ? 2.603   11.495  -7.293  1.00 12.52 ? 261 TYR A CE1 1 
ATOM   1860 C CE2 . TYR A 1 261 ? 0.234   11.452  -7.631  1.00 13.46 ? 261 TYR A CE2 1 
ATOM   1861 C CZ  . TYR A 1 261 ? 1.404   12.169  -7.446  1.00 13.21 ? 261 TYR A CZ  1 
ATOM   1862 O OH  . TYR A 1 261 ? 1.371   13.522  -7.287  1.00 12.36 ? 261 TYR A OH  1 
ATOM   1863 N N   . GLN A 1 262 ? 0.614   4.835   -6.562  1.00 12.19 ? 262 GLN A N   1 
ATOM   1864 C CA  . GLN A 1 262 ? 0.721   3.391   -6.738  1.00 13.94 ? 262 GLN A CA  1 
ATOM   1865 C C   . GLN A 1 262 ? -0.245  2.965   -7.830  1.00 14.33 ? 262 GLN A C   1 
ATOM   1866 O O   . GLN A 1 262 ? -1.406  3.345   -7.764  1.00 16.65 ? 262 GLN A O   1 
ATOM   1867 C CB  . GLN A 1 262 ? 0.411   2.657   -5.443  1.00 14.34 ? 262 GLN A CB  1 
ATOM   1868 C CG  . GLN A 1 262 ? 1.471   2.829   -4.376  1.00 16.15 ? 262 GLN A CG  1 
ATOM   1869 C CD  . GLN A 1 262 ? 1.049   2.199   -3.077  1.00 20.31 ? 262 GLN A CD  1 
ATOM   1870 O OE1 . GLN A 1 262 ? 0.208   2.717   -2.331  1.00 23.66 ? 262 GLN A OE1 1 
ATOM   1871 N NE2 . GLN A 1 262 ? 1.701   1.107   -2.757  1.00 20.66 ? 262 GLN A NE2 1 
ATOM   1872 N N   . TYR A 1 263 ? 0.244   2.162   -8.776  1.00 14.59 ? 263 TYR A N   1 
ATOM   1873 C CA  . TYR A 1 263 ? -0.557  1.625   -9.857  1.00 15.83 ? 263 TYR A CA  1 
ATOM   1874 C C   . TYR A 1 263 ? -0.640  0.107   -9.702  1.00 18.60 ? 263 TYR A C   1 
ATOM   1875 O O   . TYR A 1 263 ? 0.272   -0.550  -9.217  1.00 19.18 ? 263 TYR A O   1 
ATOM   1876 C CB  . TYR A 1 263 ? 0.032   2.045   -11.207 1.00 16.56 ? 263 TYR A CB  1 
ATOM   1877 C CG  . TYR A 1 263 ? 0.095   3.551   -11.340 1.00 17.96 ? 263 TYR A CG  1 
ATOM   1878 C CD1 . TYR A 1 263 ? 1.154   4.288   -10.789 1.00 18.67 ? 263 TYR A CD1 1 
ATOM   1879 C CD2 . TYR A 1 263 ? -0.950  4.244   -11.922 1.00 19.01 ? 263 TYR A CD2 1 
ATOM   1880 C CE1 . TYR A 1 263 ? 1.194   5.666   -10.885 1.00 17.90 ? 263 TYR A CE1 1 
ATOM   1881 C CE2 . TYR A 1 263 ? -0.931  5.628   -12.001 1.00 19.80 ? 263 TYR A CE2 1 
ATOM   1882 C CZ  . TYR A 1 263 ? 0.151   6.335   -11.493 1.00 19.89 ? 263 TYR A CZ  1 
ATOM   1883 O OH  . TYR A 1 263 ? 0.164   7.691   -11.588 1.00 20.51 ? 263 TYR A OH  1 
ATOM   1884 N N   . GLY A 1 264 ? -1.746  -0.486  -10.118 1.00 20.82 ? 264 GLY A N   1 
ATOM   1885 C CA  . GLY A 1 264 ? -1.894  -1.921  -9.969  1.00 25.50 ? 264 GLY A CA  1 
ATOM   1886 C C   . GLY A 1 264 ? -3.134  -2.411  -10.704 1.00 29.38 ? 264 GLY A C   1 
ATOM   1887 O O   . GLY A 1 264 ? -3.828  -1.606  -11.304 1.00 28.86 ? 264 GLY A O   1 
ATOM   1888 N N   . ASN A 1 265 ? -3.341  -3.731  -10.699 1.00 34.94 ? 265 ASN A N   1 
ATOM   1889 C CA  . ASN A 1 265 ? -4.486  -4.367  -11.345 1.00 44.42 ? 265 ASN A CA  1 
ATOM   1890 C C   . ASN A 1 265 ? -5.025  -5.440  -10.400 1.00 51.09 ? 265 ASN A C   1 
ATOM   1891 O O   . ASN A 1 265 ? -5.018  -5.235  -9.189  1.00 48.97 ? 265 ASN A O   1 
ATOM   1892 C CB  . ASN A 1 265 ? -4.153  -4.869  -12.759 1.00 47.66 ? 265 ASN A CB  1 
ATOM   1893 C CG  . ASN A 1 265 ? -2.983  -5.831  -12.846 1.00 50.03 ? 265 ASN A CG  1 
ATOM   1894 O OD1 . ASN A 1 265 ? -2.753  -6.640  -11.944 1.00 54.25 ? 265 ASN A OD1 1 
ATOM   1895 N ND2 . ASN A 1 265 ? -2.232  -5.748  -13.934 1.00 47.70 ? 265 ASN A ND2 1 
ATOM   1896 N N   . GLY A 1 266 ? -5.486  -6.570  -10.953 1.00 59.88 ? 266 GLY A N   1 
ATOM   1897 C CA  . GLY A 1 266 ? -5.892  -7.729  -10.171 1.00 62.32 ? 266 GLY A CA  1 
ATOM   1898 C C   . GLY A 1 266 ? -4.986  -7.967  -8.964  1.00 62.31 ? 266 GLY A C   1 
ATOM   1899 O O   . GLY A 1 266 ? -4.144  -8.866  -8.984  1.00 58.22 ? 266 GLY A O   1 
ATOM   1900 N N   . ASP A 1 267 ? -5.179  -7.115  -7.943  1.00 61.28 ? 267 ASP A N   1 
ATOM   1901 C CA  . ASP A 1 267 ? -4.617  -7.258  -6.611  1.00 55.15 ? 267 ASP A CA  1 
ATOM   1902 C C   . ASP A 1 267 ? -3.076  -7.257  -6.617  1.00 53.65 ? 267 ASP A C   1 
ATOM   1903 O O   . ASP A 1 267 ? -2.467  -7.920  -5.776  1.00 50.18 ? 267 ASP A O   1 
ATOM   1904 C CB  . ASP A 1 267 ? -5.173  -8.528  -5.950  1.00 69.88 ? 267 ASP A CB  1 
ATOM   1905 C CG  . ASP A 1 267 ? -6.544  -9.024  -6.406  1.00 70.24 ? 267 ASP A CG  1 
ATOM   1906 O OD1 . ASP A 1 267 ? -6.620  -9.646  -7.498  1.00 65.26 ? 267 ASP A OD1 1 
ATOM   1907 O OD2 . ASP A 1 267 ? -7.520  -8.831  -5.647  1.00 69.17 ? 267 ASP A OD2 1 
ATOM   1908 N N   . ASN A 1 268 ? -2.433  -6.492  -7.521  1.00 46.97 ? 268 ASN A N   1 
ATOM   1909 C CA  . ASN A 1 268 ? -0.982  -6.312  -7.523  1.00 42.74 ? 268 ASN A CA  1 
ATOM   1910 C C   . ASN A 1 268 ? -0.665  -4.832  -7.278  1.00 37.25 ? 268 ASN A C   1 
ATOM   1911 O O   . ASN A 1 268 ? 0.077   -4.152  -8.004  1.00 33.77 ? 268 ASN A O   1 
ATOM   1912 C CB  . ASN A 1 268 ? -0.350  -6.866  -8.800  1.00 48.46 ? 268 ASN A CB  1 
ATOM   1913 C CG  . ASN A 1 268 ? -0.779  -6.101  -10.037 1.00 58.39 ? 268 ASN A CG  1 
ATOM   1914 O OD1 . ASN A 1 268 ? -1.555  -5.149  -9.944  1.00 52.00 ? 268 ASN A OD1 1 
ATOM   1915 N ND2 . ASN A 1 268 ? -0.284  -6.503  -11.201 1.00 63.56 ? 268 ASN A ND2 1 
ATOM   1916 N N   . ARG A 1 269 ? -1.180  -4.364  -6.156  1.00 28.46 ? 269 ARG A N   1 
ATOM   1917 C CA  . ARG A 1 269 ? -1.221  -2.959  -5.798  1.00 28.05 ? 269 ARG A CA  1 
ATOM   1918 C C   . ARG A 1 269 ? 0.206   -2.411  -5.689  1.00 20.85 ? 269 ARG A C   1 
ATOM   1919 O O   . ARG A 1 269 ? 1.028   -2.997  -5.002  1.00 25.54 ? 269 ARG A O   1 
ATOM   1920 C CB  . ARG A 1 269 ? -1.952  -2.852  -4.452  1.00 31.01 ? 269 ARG A CB  1 
ATOM   1921 C CG  . ARG A 1 269 ? -3.245  -3.654  -4.368  1.00 36.20 ? 269 ARG A CG  1 
ATOM   1922 C CD  . ARG A 1 269 ? -3.988  -3.358  -3.071  1.00 40.36 ? 269 ARG A CD  1 
ATOM   1923 N NE  . ARG A 1 269 ? -5.169  -4.192  -2.945  1.00 42.56 ? 269 ARG A NE  1 
ATOM   1924 C CZ  . ARG A 1 269 ? -5.873  -4.354  -1.828  1.00 48.57 ? 269 ARG A CZ  1 
ATOM   1925 N NH1 . ARG A 1 269 ? -5.509  -3.745  -0.711  1.00 46.72 ? 269 ARG A NH1 1 
ATOM   1926 N NH2 . ARG A 1 269 ? -6.938  -5.141  -1.834  1.00 50.95 ? 269 ARG A NH2 1 
ATOM   1927 N N   . GLY A 1 270 ? 0.532   -1.342  -6.411  1.00 17.69 ? 270 GLY A N   1 
ATOM   1928 C CA  . GLY A 1 270 ? 1.842   -0.717  -6.238  1.00 16.92 ? 270 GLY A CA  1 
ATOM   1929 C C   . GLY A 1 270 ? 2.959   -1.357  -7.066  1.00 16.67 ? 270 GLY A C   1 
ATOM   1930 O O   . GLY A 1 270 ? 4.144   -1.057  -6.851  1.00 15.75 ? 270 GLY A O   1 
ATOM   1931 N N   . ILE A 1 271 ? 2.604   -2.208  -8.044  1.00 15.01 ? 271 ILE A N   1 
ATOM   1932 C CA  . ILE A 1 271 ? 3.619   -2.840  -8.875  1.00 14.86 ? 271 ILE A CA  1 
ATOM   1933 C C   . ILE A 1 271 ? 4.384   -1.744  -9.627  1.00 13.31 ? 271 ILE A C   1 
ATOM   1934 O O   . ILE A 1 271 ? 5.582   -1.900  -9.883  1.00 12.31 ? 271 ILE A O   1 
ATOM   1935 C CB  . ILE A 1 271 ? 3.012   -3.898  -9.822  1.00 17.69 ? 271 ILE A CB  1 
ATOM   1936 C CG1 . ILE A 1 271 ? 4.103   -4.775  -10.459 1.00 20.86 ? 271 ILE A CG1 1 
ATOM   1937 C CG2 . ILE A 1 271 ? 2.147   -3.224  -10.862 1.00 18.61 ? 271 ILE A CG2 1 
ATOM   1938 C CD1 . ILE A 1 271 ? 3.752   -6.236  -10.618 1.00 22.25 ? 271 ILE A CD1 1 
ATOM   1939 N N   . VAL A 1 272 ? 3.704   -0.646  -9.994  1.00 12.24 ? 272 VAL A N   1 
ATOM   1940 C CA  . VAL A 1 272 ? 4.396   0.597   -10.342 1.00 11.72 ? 272 VAL A CA  1 
ATOM   1941 C C   . VAL A 1 272 ? 4.115   1.640   -9.257  1.00 10.87 ? 272 VAL A C   1 
ATOM   1942 O O   . VAL A 1 272 ? 2.946   1.958   -8.969  1.00 12.29 ? 272 VAL A O   1 
ATOM   1943 C CB  . VAL A 1 272 ? 4.004   1.097   -11.752 1.00 12.25 ? 272 VAL A CB  1 
ATOM   1944 C CG1 . VAL A 1 272 ? 4.660   2.425   -12.100 1.00 12.52 ? 272 VAL A CG1 1 
ATOM   1945 C CG2 . VAL A 1 272 ? 4.310   0.089   -12.848 1.00 12.49 ? 272 VAL A CG2 1 
ATOM   1946 N N   . THR A 1 273 ? 5.175   2.173   -8.658  1.00 10.11 ? 273 THR A N   1 
ATOM   1947 C CA  . THR A 1 273 ? 5.097   3.153   -7.575  1.00 9.61  ? 273 THR A CA  1 
ATOM   1948 C C   . THR A 1 273 ? 6.023   4.329   -7.865  1.00 9.81  ? 273 THR A C   1 
ATOM   1949 O O   . THR A 1 273 ? 7.158   4.145   -8.322  1.00 10.76 ? 273 THR A O   1 
ATOM   1950 C CB  . THR A 1 273 ? 5.483   2.534   -6.231  1.00 9.80  ? 273 THR A CB  1 
ATOM   1951 O OG1 . THR A 1 273 ? 4.520   1.550   -5.876  1.00 9.20  ? 273 THR A OG1 1 
ATOM   1952 C CG2 . THR A 1 273 ? 5.619   3.540   -5.108  1.00 9.69  ? 273 THR A CG2 1 
ATOM   1953 N N   . HIS A 1 274 ? 5.532   5.538   -7.595  1.00 8.49  ? 274 HIS A N   1 
ATOM   1954 C CA  . HIS A 1 274 ? 6.308   6.733   -7.802  1.00 8.86  ? 274 HIS A CA  1 
ATOM   1955 C C   . HIS A 1 274 ? 6.187   7.583   -6.549  1.00 10.36 ? 274 HIS A C   1 
ATOM   1956 O O   . HIS A 1 274 ? 5.065   7.813   -6.057  1.00 9.77  ? 274 HIS A O   1 
ATOM   1957 C CB  . HIS A 1 274 ? 5.858   7.497   -9.042  1.00 8.42  ? 274 HIS A CB  1 
ATOM   1958 C CG  . HIS A 1 274 ? 6.431   8.876   -9.161  1.00 8.94  ? 274 HIS A CG  1 
ATOM   1959 N ND1 . HIS A 1 274 ? 7.795   9.092   -9.122  1.00 8.31  ? 274 HIS A ND1 1 
ATOM   1960 C CD2 . HIS A 1 274 ? 5.860   10.089  -9.317  1.00 9.31  ? 274 HIS A CD2 1 
ATOM   1961 C CE1 . HIS A 1 274 ? 8.021   10.395  -9.269  1.00 9.42  ? 274 HIS A CE1 1 
ATOM   1962 N NE2 . HIS A 1 274 ? 6.862   11.027  -9.411  1.00 9.39  ? 274 HIS A NE2 1 
ATOM   1963 N N   . TYR A 1 275 ? 7.353   8.065   -6.089  1.00 10.11 ? 275 TYR A N   1 
ATOM   1964 C CA  . TYR A 1 275 ? 7.408   9.047   -5.018  1.00 9.99  ? 275 TYR A CA  1 
ATOM   1965 C C   . TYR A 1 275 ? 7.843   10.380  -5.611  1.00 9.75  ? 275 TYR A C   1 
ATOM   1966 O O   . TYR A 1 275 ? 8.953   10.509  -6.151  1.00 9.38  ? 275 TYR A O   1 
ATOM   1967 C CB  . TYR A 1 275 ? 8.348   8.683   -3.866  1.00 10.59 ? 275 TYR A CB  1 
ATOM   1968 C CG  . TYR A 1 275 ? 7.909   7.503   -3.021  1.00 10.62 ? 275 TYR A CG  1 
ATOM   1969 C CD1 . TYR A 1 275 ? 8.046   6.199   -3.481  1.00 10.03 ? 275 TYR A CD1 1 
ATOM   1970 C CD2 . TYR A 1 275 ? 7.360   7.697   -1.748  1.00 12.06 ? 275 TYR A CD2 1 
ATOM   1971 C CE1 . TYR A 1 275 ? 7.661   5.119   -2.719  1.00 10.30 ? 275 TYR A CE1 1 
ATOM   1972 C CE2 . TYR A 1 275 ? 6.952   6.620   -0.987  1.00 11.53 ? 275 TYR A CE2 1 
ATOM   1973 C CZ  . TYR A 1 275 ? 7.086   5.335   -1.485  1.00 11.94 ? 275 TYR A CZ  1 
ATOM   1974 O OH  . TYR A 1 275 ? 6.743   4.264   -0.740  1.00 10.12 ? 275 TYR A OH  1 
ATOM   1975 N N   . ARG A 1 276 ? 6.936   11.348  -5.516  1.00 9.08  ? 276 ARG A N   1 
ATOM   1976 C CA  . ARG A 1 276 ? 7.223   12.720  -5.877  1.00 10.61 ? 276 ARG A CA  1 
ATOM   1977 C C   . ARG A 1 276 ? 7.608   13.498  -4.628  1.00 10.28 ? 276 ARG A C   1 
ATOM   1978 O O   . ARG A 1 276 ? 6.806   13.632  -3.680  1.00 10.40 ? 276 ARG A O   1 
ATOM   1979 C CB  . ARG A 1 276 ? 5.998   13.268  -6.618  1.00 11.94 ? 276 ARG A CB  1 
ATOM   1980 C CG  . ARG A 1 276 ? 6.021   14.757  -6.921  1.00 14.70 ? 276 ARG A CG  1 
ATOM   1981 C CD  . ARG A 1 276 ? 4.677   15.068  -7.563  1.00 18.35 ? 276 ARG A CD  1 
ATOM   1982 N NE  . ARG A 1 276 ? 4.591   16.477  -7.890  1.00 24.56 ? 276 ARG A NE  1 
ATOM   1983 C CZ  . ARG A 1 276 ? 3.705   17.338  -7.385  1.00 32.13 ? 276 ARG A CZ  1 
ATOM   1984 N NH1 . ARG A 1 276 ? 2.658   16.923  -6.675  1.00 34.80 ? 276 ARG A NH1 1 
ATOM   1985 N NH2 . ARG A 1 276 ? 3.860   18.632  -7.632  1.00 31.99 ? 276 ARG A NH2 1 
ATOM   1986 N N   . ILE A 1 277 ? 8.831   14.043  -4.620  1.00 10.28 ? 277 ILE A N   1 
ATOM   1987 C CA  . ILE A 1 277 ? 9.354   14.659  -3.395  1.00 11.19 ? 277 ILE A CA  1 
ATOM   1988 C C   . ILE A 1 277 ? 9.438   16.172  -3.570  1.00 11.76 ? 277 ILE A C   1 
ATOM   1989 O O   . ILE A 1 277 ? 10.239  16.685  -4.341  1.00 11.88 ? 277 ILE A O   1 
ATOM   1990 C CB  . ILE A 1 277 ? 10.683  14.022  -2.957  1.00 12.74 ? 277 ILE A CB  1 
ATOM   1991 C CG1 . ILE A 1 277 ? 10.543  12.498  -2.870  1.00 14.38 ? 277 ILE A CG1 1 
ATOM   1992 C CG2 . ILE A 1 277 ? 11.201  14.637  -1.639  1.00 13.73 ? 277 ILE A CG2 1 
ATOM   1993 C CD1 . ILE A 1 277 ? 11.872  11.812  -2.639  1.00 16.66 ? 277 ILE A CD1 1 
ATOM   1994 N N   . GLY A 1 278 ? 8.557   16.884  -2.858  1.00 12.76 ? 278 GLY A N   1 
ATOM   1995 C CA  . GLY A 1 278 ? 8.375   18.312  -3.077  1.00 12.80 ? 278 GLY A CA  1 
ATOM   1996 C C   . GLY A 1 278 ? 9.600   19.101  -2.647  1.00 13.88 ? 278 GLY A C   1 
ATOM   1997 O O   . GLY A 1 278 ? 10.093  18.939  -1.534  1.00 16.29 ? 278 GLY A O   1 
ATOM   1998 N N   . GLY A 1 279 ? 10.126  19.906  -3.574  1.00 16.29 ? 279 GLY A N   1 
ATOM   1999 C CA  . GLY A 1 279 ? 11.269  20.773  -3.287  1.00 15.82 ? 279 GLY A CA  1 
ATOM   2000 C C   . GLY A 1 279 ? 12.629  20.087  -3.396  1.00 15.62 ? 279 GLY A C   1 
ATOM   2001 O O   . GLY A 1 279 ? 13.644  20.731  -3.180  1.00 14.71 ? 279 GLY A O   1 
ATOM   2002 N N   . LEU A 1 280 ? 12.674  18.770  -3.604  1.00 14.03 ? 280 LEU A N   1 
ATOM   2003 C CA  . LEU A 1 280 ? 13.954  18.081  -3.662  1.00 13.61 ? 280 LEU A CA  1 
ATOM   2004 C C   . LEU A 1 280 ? 14.577  18.332  -5.029  1.00 12.06 ? 280 LEU A C   1 
ATOM   2005 O O   . LEU A 1 280 ? 13.850  18.394  -6.011  1.00 11.57 ? 280 LEU A O   1 
ATOM   2006 C CB  . LEU A 1 280 ? 13.748  16.577  -3.446  1.00 13.42 ? 280 LEU A CB  1 
ATOM   2007 C CG  . LEU A 1 280 ? 15.031  15.744  -3.388  1.00 13.83 ? 280 LEU A CG  1 
ATOM   2008 C CD1 . LEU A 1 280 ? 15.824  16.054  -2.122  1.00 14.73 ? 280 LEU A CD1 1 
ATOM   2009 C CD2 . LEU A 1 280 ? 14.709  14.250  -3.414  1.00 14.14 ? 280 LEU A CD2 1 
ATOM   2010 N N   . GLY A 1 281 ? 15.907  18.508  -5.044  1.00 12.12 ? 281 GLY A N   1 
ATOM   2011 C CA  . GLY A 1 281 ? 16.700  18.588  -6.267  1.00 12.64 ? 281 GLY A CA  1 
ATOM   2012 C C   . GLY A 1 281 ? 17.041  17.206  -6.846  1.00 12.62 ? 281 GLY A C   1 
ATOM   2013 O O   . GLY A 1 281 ? 16.261  16.235  -6.703  1.00 12.04 ? 281 GLY A O   1 
ATOM   2014 N N   . HIS A 1 282 ? 18.196  17.168  -7.526  1.00 11.15 ? 282 HIS A N   1 
ATOM   2015 C CA  . HIS A 1 282 ? 18.720  16.017  -8.240  1.00 11.74 ? 282 HIS A CA  1 
ATOM   2016 C C   . HIS A 1 282 ? 19.448  15.064  -7.294  1.00 11.26 ? 282 HIS A C   1 
ATOM   2017 O O   . HIS A 1 282 ? 20.662  14.834  -7.411  1.00 11.58 ? 282 HIS A O   1 
ATOM   2018 C CB  . HIS A 1 282 ? 19.655  16.499  -9.367  1.00 11.99 ? 282 HIS A CB  1 
ATOM   2019 C CG  . HIS A 1 282 ? 20.018  15.394  -10.297 1.00 11.52 ? 282 HIS A CG  1 
ATOM   2020 N ND1 . HIS A 1 282 ? 19.039  14.702  -11.001 1.00 11.74 ? 282 HIS A ND1 1 
ATOM   2021 C CD2 . HIS A 1 282 ? 21.199  14.844  -10.642 1.00 12.17 ? 282 HIS A CD2 1 
ATOM   2022 C CE1 . HIS A 1 282 ? 19.629  13.764  -11.751 1.00 11.95 ? 282 HIS A CE1 1 
ATOM   2023 N NE2 . HIS A 1 282 ? 20.929  13.797  -11.519 1.00 12.12 ? 282 HIS A NE2 1 
ATOM   2024 N N   . ASP A 1 283 ? 18.705  14.490  -6.348  1.00 10.90 ? 283 ASP A N   1 
ATOM   2025 C CA  . ASP A 1 283 ? 19.309  13.960  -5.144  1.00 10.82 ? 283 ASP A CA  1 
ATOM   2026 C C   . ASP A 1 283 ? 18.756  12.588  -4.794  1.00 10.24 ? 283 ASP A C   1 
ATOM   2027 O O   . ASP A 1 283 ? 17.542  12.427  -4.728  1.00 11.48 ? 283 ASP A O   1 
ATOM   2028 C CB  . ASP A 1 283 ? 18.979  14.880  -3.967  1.00 11.71 ? 283 ASP A CB  1 
ATOM   2029 C CG  . ASP A 1 283 ? 19.418  16.320  -4.206  1.00 12.59 ? 283 ASP A CG  1 
ATOM   2030 O OD1 . ASP A 1 283 ? 20.562  16.488  -4.621  1.00 12.19 ? 283 ASP A OD1 1 
ATOM   2031 O OD2 . ASP A 1 283 ? 18.626  17.248  -3.958  1.00 14.35 ? 283 ASP A OD2 1 
ATOM   2032 N N   . TRP A 1 284 ? 19.654  11.647  -4.461  1.00 10.09 ? 284 TRP A N   1 
ATOM   2033 C CA  . TRP A 1 284 ? 19.239  10.423  -3.796  1.00 8.96  ? 284 TRP A CA  1 
ATOM   2034 C C   . TRP A 1 284 ? 18.568  10.806  -2.476  1.00 8.89  ? 284 TRP A C   1 
ATOM   2035 O O   . TRP A 1 284 ? 19.175  11.527  -1.661  1.00 8.89  ? 284 TRP A O   1 
ATOM   2036 C CB  . TRP A 1 284 ? 20.436  9.509   -3.549  1.00 8.33  ? 284 TRP A CB  1 
ATOM   2037 C CG  . TRP A 1 284 ? 20.029  8.127   -3.108  1.00 8.28  ? 284 TRP A CG  1 
ATOM   2038 C CD1 . TRP A 1 284 ? 19.664  7.704   -1.869  1.00 8.81  ? 284 TRP A CD1 1 
ATOM   2039 C CD2 . TRP A 1 284 ? 19.960  6.964   -3.946  1.00 8.16  ? 284 TRP A CD2 1 
ATOM   2040 N NE1 . TRP A 1 284 ? 19.362  6.354   -1.881  1.00 8.57  ? 284 TRP A NE1 1 
ATOM   2041 C CE2 . TRP A 1 284 ? 19.531  5.882   -3.143  1.00 8.42  ? 284 TRP A CE2 1 
ATOM   2042 C CE3 . TRP A 1 284 ? 20.216  6.737   -5.303  1.00 7.92  ? 284 TRP A CE3 1 
ATOM   2043 C CZ2 . TRP A 1 284 ? 19.348  4.586   -3.654  1.00 8.72  ? 284 TRP A CZ2 1 
ATOM   2044 C CZ3 . TRP A 1 284 ? 20.058  5.473   -5.795  1.00 7.88  ? 284 TRP A CZ3 1 
ATOM   2045 C CH2 . TRP A 1 284 ? 19.644  4.404   -4.985  1.00 8.54  ? 284 TRP A CH2 1 
ATOM   2046 N N   . PRO A 1 285 ? 17.289  10.452  -2.216  1.00 9.22  ? 285 PRO A N   1 
ATOM   2047 C CA  . PRO A 1 285 ? 16.659  10.864  -0.951  1.00 8.98  ? 285 PRO A CA  1 
ATOM   2048 C C   . PRO A 1 285 ? 17.231  10.194  0.290   1.00 8.94  ? 285 PRO A C   1 
ATOM   2049 O O   . PRO A 1 285 ? 17.244  8.984   0.386   1.00 8.32  ? 285 PRO A O   1 
ATOM   2050 C CB  . PRO A 1 285 ? 15.182  10.522  -1.119  1.00 9.12  ? 285 PRO A CB  1 
ATOM   2051 C CG  . PRO A 1 285 ? 15.008  10.341  -2.622  1.00 9.23  ? 285 PRO A CG  1 
ATOM   2052 C CD  . PRO A 1 285 ? 16.331  9.775   -3.118  1.00 9.02  ? 285 PRO A CD  1 
ATOM   2053 N N   . SER A 1 286 ? 17.685  11.053  1.215   1.00 9.65  ? 286 SER A N   1 
ATOM   2054 C CA  A SER A 1 286 ? 18.196  10.662  2.514   0.50 9.86  ? 286 SER A CA  1 
ATOM   2055 C CA  B SER A 1 286 ? 18.224  10.673  2.500   0.50 9.50  ? 286 SER A CA  1 
ATOM   2056 C C   . SER A 1 286 ? 17.778  11.700  3.549   1.00 10.11 ? 286 SER A C   1 
ATOM   2057 O O   . SER A 1 286 ? 17.723  12.901  3.262   1.00 9.74  ? 286 SER A O   1 
ATOM   2058 C CB  A SER A 1 286 ? 19.687  10.512  2.526   0.50 10.67 ? 286 SER A CB  1 
ATOM   2059 C CB  B SER A 1 286 ? 19.724  10.574  2.419   0.50 9.85  ? 286 SER A CB  1 
ATOM   2060 O OG  A SER A 1 286 ? 20.153  10.084  3.810   0.50 11.17 ? 286 SER A OG  1 
ATOM   2061 O OG  B SER A 1 286 ? 20.147  9.508   1.558   0.50 9.42  ? 286 SER A OG  1 
ATOM   2062 N N   . VAL A 1 287 ? 17.474  11.227  4.761   1.00 10.75 ? 287 VAL A N   1 
ATOM   2063 C CA  . VAL A 1 287 ? 17.156  12.131  5.859   1.00 12.24 ? 287 VAL A CA  1 
ATOM   2064 C C   . VAL A 1 287 ? 18.435  12.884  6.255   1.00 13.46 ? 287 VAL A C   1 
ATOM   2065 O O   . VAL A 1 287 ? 18.394  14.077  6.556   1.00 14.06 ? 287 VAL A O   1 
ATOM   2066 C CB  . VAL A 1 287 ? 16.533  11.309  7.007   1.00 14.12 ? 287 VAL A CB  1 
ATOM   2067 C CG1 . VAL A 1 287 ? 16.452  12.059  8.336   1.00 16.51 ? 287 VAL A CG1 1 
ATOM   2068 C CG2 . VAL A 1 287 ? 15.169  10.772  6.573   1.00 13.43 ? 287 VAL A CG2 1 
ATOM   2069 N N   . ARG A 1 288 ? 19.557  12.162  6.288   1.00 14.80 ? 288 ARG A N   1 
ATOM   2070 C CA  . ARG A 1 288 ? 20.876  12.706  6.597   1.00 16.08 ? 288 ARG A CA  1 
ATOM   2071 C C   . ARG A 1 288 ? 21.508  13.356  5.358   1.00 14.38 ? 288 ARG A C   1 
ATOM   2072 O O   . ARG A 1 288 ? 21.135  13.070  4.224   1.00 12.86 ? 288 ARG A O   1 
ATOM   2073 C CB  . ARG A 1 288 ? 21.792  11.583  7.082   1.00 19.55 ? 288 ARG A CB  1 
ATOM   2074 C CG  . ARG A 1 288 ? 21.450  11.084  8.474   1.00 27.00 ? 288 ARG A CG  1 
ATOM   2075 C CD  . ARG A 1 288 ? 22.480  10.038  8.848   1.00 35.12 ? 288 ARG A CD  1 
ATOM   2076 N NE  . ARG A 1 288 ? 22.444  9.694   10.270  1.00 50.42 ? 288 ARG A NE  1 
ATOM   2077 C CZ  . ARG A 1 288 ? 23.305  8.877   10.879  1.00 59.16 ? 288 ARG A CZ  1 
ATOM   2078 N NH1 . ARG A 1 288 ? 24.262  8.269   10.196  1.00 63.81 ? 288 ARG A NH1 1 
ATOM   2079 N NH2 . ARG A 1 288 ? 23.201  8.661   12.181  1.00 65.34 ? 288 ARG A NH2 1 
ATOM   2080 N N   . PRO A 1 289 ? 22.492  14.264  5.530   1.00 12.93 ? 289 PRO A N   1 
ATOM   2081 C CA  . PRO A 1 289 ? 23.256  14.776  4.395   1.00 13.10 ? 289 PRO A CA  1 
ATOM   2082 C C   . PRO A 1 289 ? 23.853  13.621  3.593   1.00 12.69 ? 289 PRO A C   1 
ATOM   2083 O O   . PRO A 1 289 ? 24.204  12.599  4.165   1.00 11.98 ? 289 PRO A O   1 
ATOM   2084 C CB  . PRO A 1 289 ? 24.370  15.592  5.070   1.00 14.77 ? 289 PRO A CB  1 
ATOM   2085 C CG  . PRO A 1 289 ? 23.735  16.048  6.412   1.00 14.74 ? 289 PRO A CG  1 
ATOM   2086 C CD  . PRO A 1 289 ? 22.861  14.883  6.822   1.00 14.80 ? 289 PRO A CD  1 
ATOM   2087 N N   . ASN A 1 290 ? 23.983  13.771  2.276   1.00 11.88 ? 290 ASN A N   1 
ATOM   2088 C CA  . ASN A 1 290 ? 24.760  12.815  1.496   1.00 11.25 ? 290 ASN A CA  1 
ATOM   2089 C C   . ASN A 1 290 ? 25.540  13.616  0.462   1.00 11.55 ? 290 ASN A C   1 
ATOM   2090 O O   . ASN A 1 290 ? 25.448  14.848  0.436   1.00 10.19 ? 290 ASN A O   1 
ATOM   2091 C CB  . ASN A 1 290 ? 23.856  11.710  0.949   1.00 10.42 ? 290 ASN A CB  1 
ATOM   2092 C CG  . ASN A 1 290 ? 22.808  12.208  -0.025  1.00 11.13 ? 290 ASN A CG  1 
ATOM   2093 O OD1 . ASN A 1 290 ? 22.974  13.240  -0.678  1.00 10.72 ? 290 ASN A OD1 1 
ATOM   2094 N ND2 . ASN A 1 290 ? 21.719  11.461  -0.135  1.00 10.99 ? 290 ASN A ND2 1 
ATOM   2095 N N   . SER A 1 291 ? 26.261  12.910  -0.420  1.00 11.60 ? 291 SER A N   1 
ATOM   2096 C CA  . SER A 1 291 ? 27.153  13.580  -1.351  1.00 12.14 ? 291 SER A CA  1 
ATOM   2097 C C   . SER A 1 291 ? 26.353  14.388  -2.353  1.00 12.23 ? 291 SER A C   1 
ATOM   2098 O O   . SER A 1 291 ? 26.899  15.342  -2.897  1.00 13.61 ? 291 SER A O   1 
ATOM   2099 C CB  . SER A 1 291 ? 28.111  12.614  -2.038  1.00 12.57 ? 291 SER A CB  1 
ATOM   2100 O OG  . SER A 1 291 ? 27.404  11.609  -2.753  1.00 13.87 ? 291 SER A OG  1 
ATOM   2101 N N   . ASP A 1 292 ? 25.085  14.028  -2.580  1.00 10.63 ? 292 ASP A N   1 
ATOM   2102 C CA  . ASP A 1 292 ? 24.224  14.782  -3.486  1.00 11.82 ? 292 ASP A CA  1 
ATOM   2103 C C   . ASP A 1 292 ? 23.698  16.053  -2.816  1.00 11.80 ? 292 ASP A C   1 
ATOM   2104 O O   . ASP A 1 292 ? 23.527  17.073  -3.475  1.00 12.25 ? 292 ASP A O   1 
ATOM   2105 C CB  . ASP A 1 292 ? 22.992  13.981  -3.939  1.00 11.32 ? 292 ASP A CB  1 
ATOM   2106 C CG  . ASP A 1 292 ? 23.193  12.963  -5.061  1.00 11.98 ? 292 ASP A CG  1 
ATOM   2107 O OD1 . ASP A 1 292 ? 24.247  12.975  -5.721  1.00 10.57 ? 292 ASP A OD1 1 
ATOM   2108 O OD2 . ASP A 1 292 ? 22.263  12.144  -5.279  1.00 11.22 ? 292 ASP A OD2 1 
ATOM   2109 N N   . ASN A 1 293 ? 23.275  15.921  -1.564  1.00 12.13 ? 293 ASN A N   1 
ATOM   2110 C CA  . ASN A 1 293 ? 22.369  16.885  -0.959  1.00 12.90 ? 293 ASN A CA  1 
ATOM   2111 C C   . ASN A 1 293 ? 22.847  17.147  0.466   1.00 12.22 ? 293 ASN A C   1 
ATOM   2112 O O   . ASN A 1 293 ? 22.740  16.265  1.313   1.00 13.20 ? 293 ASN A O   1 
ATOM   2113 C CB  . ASN A 1 293 ? 20.933  16.346  -0.922  1.00 12.72 ? 293 ASN A CB  1 
ATOM   2114 C CG  . ASN A 1 293 ? 19.940  17.284  -0.250  1.00 13.35 ? 293 ASN A CG  1 
ATOM   2115 O OD1 . ASN A 1 293 ? 20.276  18.379  0.192   1.00 13.46 ? 293 ASN A OD1 1 
ATOM   2116 N ND2 . ASN A 1 293 ? 18.707  16.834  -0.124  1.00 13.53 ? 293 ASN A ND2 1 
ATOM   2117 N N   . PRO A 1 294 ? 23.304  18.368  0.795   1.00 12.88 ? 294 PRO A N   1 
ATOM   2118 C CA  . PRO A 1 294 ? 23.793  18.639  2.146   1.00 15.82 ? 294 PRO A CA  1 
ATOM   2119 C C   . PRO A 1 294 ? 22.743  18.801  3.241   1.00 15.19 ? 294 PRO A C   1 
ATOM   2120 O O   . PRO A 1 294 ? 23.082  18.740  4.418   1.00 14.98 ? 294 PRO A O   1 
ATOM   2121 C CB  . PRO A 1 294 ? 24.506  19.977  1.940   1.00 15.76 ? 294 PRO A CB  1 
ATOM   2122 C CG  . PRO A 1 294 ? 23.730  20.652  0.877   1.00 15.73 ? 294 PRO A CG  1 
ATOM   2123 C CD  . PRO A 1 294 ? 23.358  19.545  -0.080  1.00 13.75 ? 294 PRO A CD  1 
ATOM   2124 N N   . ASN A 1 295 ? 21.483  18.995  2.838   1.00 15.50 ? 295 ASN A N   1 
ATOM   2125 C CA  . ASN A 1 295 ? 20.436  19.340  3.785   1.00 15.95 ? 295 ASN A CA  1 
ATOM   2126 C C   . ASN A 1 295 ? 19.642  18.150  4.287   1.00 16.33 ? 295 ASN A C   1 
ATOM   2127 O O   . ASN A 1 295 ? 19.035  18.254  5.351   1.00 17.17 ? 295 ASN A O   1 
ATOM   2128 C CB  . ASN A 1 295 ? 19.455  20.334  3.176   1.00 18.45 ? 295 ASN A CB  1 
ATOM   2129 C CG  . ASN A 1 295 ? 20.187  21.589  2.779   1.00 21.11 ? 295 ASN A CG  1 
ATOM   2130 O OD1 . ASN A 1 295 ? 21.154  21.973  3.440   1.00 18.29 ? 295 ASN A OD1 1 
ATOM   2131 N ND2 . ASN A 1 295 ? 19.780  22.167  1.674   1.00 23.31 ? 295 ASN A ND2 1 
ATOM   2132 N N   . GLY A 1 296 ? 19.574  17.049  3.542   1.00 14.82 ? 296 GLY A N   1 
ATOM   2133 C CA  . GLY A 1 296 ? 18.647  15.991  3.931   1.00 14.61 ? 296 GLY A CA  1 
ATOM   2134 C C   . GLY A 1 296 ? 17.240  16.321  3.432   1.00 14.78 ? 296 GLY A C   1 
ATOM   2135 O O   . GLY A 1 296 ? 16.939  17.479  3.138   1.00 15.21 ? 296 GLY A O   1 
ATOM   2136 N N   . THR A 1 297 ? 16.366  15.316  3.354   1.00 12.94 ? 297 THR A N   1 
ATOM   2137 C CA  . THR A 1 297 ? 14.993  15.544  2.925   1.00 11.49 ? 297 THR A CA  1 
ATOM   2138 C C   . THR A 1 297 ? 14.076  14.737  3.848   1.00 11.56 ? 297 THR A C   1 
ATOM   2139 O O   . THR A 1 297 ? 14.482  14.378  4.939   1.00 12.79 ? 297 THR A O   1 
ATOM   2140 C CB  . THR A 1 297 ? 14.875  15.257  1.423   1.00 11.64 ? 297 THR A CB  1 
ATOM   2141 O OG1 . THR A 1 297 ? 13.564  15.531  0.922   1.00 12.19 ? 297 THR A OG1 1 
ATOM   2142 C CG2 . THR A 1 297 ? 15.191  13.821  1.086   1.00 11.01 ? 297 THR A CG2 1 
ATOM   2143 N N   . TYR A 1 298 ? 12.854  14.459  3.412   1.00 11.92 ? 298 TYR A N   1 
ATOM   2144 C CA  . TYR A 1 298 ? 11.789  13.945  4.275   1.00 13.00 ? 298 TYR A CA  1 
ATOM   2145 C C   . TYR A 1 298 ? 11.967  12.466  4.605   1.00 13.50 ? 298 TYR A C   1 
ATOM   2146 O O   . TYR A 1 298 ? 11.485  12.013  5.641   1.00 13.23 ? 298 TYR A O   1 
ATOM   2147 C CB  . TYR A 1 298 ? 10.421  14.120  3.598   1.00 13.34 ? 298 TYR A CB  1 
ATOM   2148 C CG  . TYR A 1 298 ? 10.143  15.564  3.249   1.00 13.04 ? 298 TYR A CG  1 
ATOM   2149 C CD1 . TYR A 1 298 ? 9.820   16.488  4.256   1.00 13.76 ? 298 TYR A CD1 1 
ATOM   2150 C CD2 . TYR A 1 298 ? 10.343  16.038  1.950   1.00 11.99 ? 298 TYR A CD2 1 
ATOM   2151 C CE1 . TYR A 1 298 ? 9.671   17.834  3.955   1.00 14.17 ? 298 TYR A CE1 1 
ATOM   2152 C CE2 . TYR A 1 298 ? 10.185  17.373  1.642   1.00 13.25 ? 298 TYR A CE2 1 
ATOM   2153 C CZ  . TYR A 1 298 ? 9.837   18.266  2.651   1.00 15.68 ? 298 TYR A CZ  1 
ATOM   2154 O OH  . TYR A 1 298 ? 9.663   19.569  2.322   1.00 19.35 ? 298 TYR A OH  1 
ATOM   2155 N N   . LEU A 1 299 ? 12.596  11.707  3.694   1.00 12.33 ? 299 LEU A N   1 
ATOM   2156 C CA  . LEU A 1 299 ? 12.641  10.259  3.786   1.00 12.52 ? 299 LEU A CA  1 
ATOM   2157 C C   . LEU A 1 299 ? 13.943  9.709   3.216   1.00 11.48 ? 299 LEU A C   1 
ATOM   2158 O O   . LEU A 1 299 ? 14.626  10.379  2.440   1.00 10.84 ? 299 LEU A O   1 
ATOM   2159 C CB  . LEU A 1 299 ? 11.448  9.626   3.054   1.00 12.83 ? 299 LEU A CB  1 
ATOM   2160 C CG  . LEU A 1 299 ? 11.317  9.862   1.561   1.00 14.54 ? 299 LEU A CG  1 
ATOM   2161 C CD1 . LEU A 1 299 ? 12.226  8.943   0.748   1.00 14.81 ? 299 LEU A CD1 1 
ATOM   2162 C CD2 . LEU A 1 299 ? 9.880   9.643   1.126   1.00 14.75 ? 299 LEU A CD2 1 
ATOM   2163 N N   . ASP A 1 300 ? 14.244  8.469   3.624   1.00 11.27 ? 300 ASP A N   1 
ATOM   2164 C CA  . ASP A 1 300 ? 15.311  7.654   3.061   1.00 11.36 ? 300 ASP A CA  1 
ATOM   2165 C C   . ASP A 1 300 ? 14.695  6.729   2.011   1.00 10.91 ? 300 ASP A C   1 
ATOM   2166 O O   . ASP A 1 300 ? 13.858  5.878   2.339   1.00 10.43 ? 300 ASP A O   1 
ATOM   2167 C CB  . ASP A 1 300 ? 15.987  6.777   4.120   1.00 11.63 ? 300 ASP A CB  1 
ATOM   2168 C CG  . ASP A 1 300 ? 16.694  7.546   5.230   1.00 13.34 ? 300 ASP A CG  1 
ATOM   2169 O OD1 . ASP A 1 300 ? 17.559  8.349   4.918   1.00 13.30 ? 300 ASP A OD1 1 
ATOM   2170 O OD2 . ASP A 1 300 ? 16.324  7.355   6.356   1.00 13.50 ? 300 ASP A OD2 1 
ATOM   2171 N N   . ALA A 1 301 ? 15.141  6.875   0.758   1.00 10.77 ? 301 ALA A N   1 
ATOM   2172 C CA  . ALA A 1 301 ? 14.693  6.028   -0.337  1.00 10.54 ? 301 ALA A CA  1 
ATOM   2173 C C   . ALA A 1 301 ? 15.129  4.581   -0.150  1.00 9.61  ? 301 ALA A C   1 
ATOM   2174 O O   . ALA A 1 301 ? 14.383  3.677   -0.509  1.00 10.75 ? 301 ALA A O   1 
ATOM   2175 C CB  . ALA A 1 301 ? 15.199  6.551   -1.660  1.00 10.71 ? 301 ALA A CB  1 
ATOM   2176 N N   . THR A 1 302 ? 16.320  4.344   0.401   1.00 9.74  ? 302 THR A N   1 
ATOM   2177 C CA  . THR A 1 302 ? 16.908  3.013   0.303   1.00 9.59  ? 302 THR A CA  1 
ATOM   2178 C C   . THR A 1 302 ? 16.079  1.978   1.060   1.00 9.71  ? 302 THR A C   1 
ATOM   2179 O O   . THR A 1 302 ? 15.832  0.903   0.527   1.00 9.19  ? 302 THR A O   1 
ATOM   2180 C CB  . THR A 1 302 ? 18.396  3.037   0.643   1.00 9.30  ? 302 THR A CB  1 
ATOM   2181 O OG1 . THR A 1 302 ? 19.044  3.791   -0.384  1.00 8.82  ? 302 THR A OG1 1 
ATOM   2182 C CG2 . THR A 1 302 ? 19.012  1.660   0.744   1.00 9.82  ? 302 THR A CG2 1 
ATOM   2183 N N   . PRO A 1 303 ? 15.666  2.200   2.331   1.00 10.80 ? 303 PRO A N   1 
ATOM   2184 C CA  . PRO A 1 303 ? 14.795  1.226   2.998   1.00 10.72 ? 303 PRO A CA  1 
ATOM   2185 C C   . PRO A 1 303 ? 13.502  0.951   2.240   1.00 10.36 ? 303 PRO A C   1 
ATOM   2186 O O   . PRO A 1 303 ? 13.011  -0.187  2.229   1.00 10.28 ? 303 PRO A O   1 
ATOM   2187 C CB  . PRO A 1 303 ? 14.492  1.807   4.394   1.00 11.24 ? 303 PRO A CB  1 
ATOM   2188 C CG  . PRO A 1 303 ? 15.433  2.996   4.547   1.00 11.96 ? 303 PRO A CG  1 
ATOM   2189 C CD  . PRO A 1 303 ? 16.013  3.344   3.186   1.00 10.85 ? 303 PRO A CD  1 
ATOM   2190 N N   . ILE A 1 304 ? 12.930  2.001   1.626   1.00 10.11 ? 304 ILE A N   1 
ATOM   2191 C CA  . ILE A 1 304 ? 11.750  1.826   0.791   1.00 9.67  ? 304 ILE A CA  1 
ATOM   2192 C C   . ILE A 1 304 ? 12.041  0.922   -0.414  1.00 8.99  ? 304 ILE A C   1 
ATOM   2193 O O   . ILE A 1 304 ? 11.222  0.078   -0.762  1.00 8.55  ? 304 ILE A O   1 
ATOM   2194 C CB  . ILE A 1 304 ? 11.173  3.184   0.348   1.00 10.68 ? 304 ILE A CB  1 
ATOM   2195 C CG1 . ILE A 1 304 ? 10.669  3.974   1.557   1.00 10.79 ? 304 ILE A CG1 1 
ATOM   2196 C CG2 . ILE A 1 304 ? 10.077  3.003   -0.704  1.00 11.23 ? 304 ILE A CG2 1 
ATOM   2197 C CD1 . ILE A 1 304 ? 10.363  5.423   1.228   1.00 11.20 ? 304 ILE A CD1 1 
ATOM   2198 N N   . ILE A 1 305 ? 13.199  1.123   -1.074  1.00 8.45  ? 305 ILE A N   1 
ATOM   2199 C CA  . ILE A 1 305 ? 13.608  0.289   -2.202  1.00 7.99  ? 305 ILE A CA  1 
ATOM   2200 C C   . ILE A 1 305 ? 13.809  -1.172  -1.786  1.00 8.50  ? 305 ILE A C   1 
ATOM   2201 O O   . ILE A 1 305 ? 13.366  -2.080  -2.494  1.00 7.07  ? 305 ILE A O   1 
ATOM   2202 C CB  . ILE A 1 305 ? 14.868  0.863   -2.864  1.00 7.70  ? 305 ILE A CB  1 
ATOM   2203 C CG1 . ILE A 1 305 ? 14.577  2.250   -3.429  1.00 8.00  ? 305 ILE A CG1 1 
ATOM   2204 C CG2 . ILE A 1 305 ? 15.433  -0.112  -3.891  1.00 7.92  ? 305 ILE A CG2 1 
ATOM   2205 C CD1 . ILE A 1 305 ? 15.791  3.061   -3.839  1.00 8.21  ? 305 ILE A CD1 1 
ATOM   2206 N N   . VAL A 1 306 ? 14.471  -1.388  -0.636  1.00 9.18  ? 306 VAL A N   1 
ATOM   2207 C CA  . VAL A 1 306 ? 14.714  -2.751  -0.171  1.00 10.13 ? 306 VAL A CA  1 
ATOM   2208 C C   . VAL A 1 306 ? 13.387  -3.465  0.090   1.00 10.24 ? 306 VAL A C   1 
ATOM   2209 O O   . VAL A 1 306 ? 13.208  -4.646  -0.266  1.00 9.87  ? 306 VAL A O   1 
ATOM   2210 C CB  . VAL A 1 306 ? 15.643  -2.740  1.049   1.00 10.50 ? 306 VAL A CB  1 
ATOM   2211 C CG1 . VAL A 1 306 ? 15.759  -4.106  1.731   1.00 11.11 ? 306 VAL A CG1 1 
ATOM   2212 C CG2 . VAL A 1 306 ? 17.035  -2.225  0.667   1.00 10.36 ? 306 VAL A CG2 1 
ATOM   2213 N N   . LYS A 1 307 ? 12.446  -2.746  0.722   1.00 10.96 ? 307 LYS A N   1 
ATOM   2214 C CA  . LYS A 1 307 ? 11.143  -3.320  1.025   1.00 12.22 ? 307 LYS A CA  1 
ATOM   2215 C C   . LYS A 1 307 ? 10.379  -3.636  -0.270  1.00 10.50 ? 307 LYS A C   1 
ATOM   2216 O O   . LYS A 1 307 ? 9.719   -4.680  -0.371  1.00 10.12 ? 307 LYS A O   1 
ATOM   2217 C CB  . LYS A 1 307 ? 10.335  -2.385  1.921   1.00 14.15 ? 307 LYS A CB  1 
ATOM   2218 C CG  . LYS A 1 307 ? 8.963   -2.927  2.307   1.00 17.25 ? 307 LYS A CG  1 
ATOM   2219 C CD  . LYS A 1 307 ? 8.156   -1.890  3.050   1.00 22.73 ? 307 LYS A CD  1 
ATOM   2220 C CE  . LYS A 1 307 ? 6.763   -2.360  3.410   1.00 27.33 ? 307 LYS A CE  1 
ATOM   2221 N NZ  . LYS A 1 307 ? 6.842   -3.429  4.416   1.00 30.92 ? 307 LYS A NZ  1 
ATOM   2222 N N   . PHE A 1 308 ? 10.567  -2.789  -1.291  1.00 10.21 ? 308 PHE A N   1 
ATOM   2223 C CA  . PHE A 1 308 ? 9.904   -2.942  -2.572  1.00 10.30 ? 308 PHE A CA  1 
ATOM   2224 C C   . PHE A 1 308 ? 10.434  -4.199  -3.252  1.00 10.09 ? 308 PHE A C   1 
ATOM   2225 O O   . PHE A 1 308 ? 9.647   -5.008  -3.725  1.00 10.28 ? 308 PHE A O   1 
ATOM   2226 C CB  . PHE A 1 308 ? 10.063  -1.689  -3.437  1.00 10.56 ? 308 PHE A CB  1 
ATOM   2227 C CG  . PHE A 1 308 ? 9.362   -1.692  -4.771  1.00 11.18 ? 308 PHE A CG  1 
ATOM   2228 C CD1 . PHE A 1 308 ? 8.026   -1.336  -4.884  1.00 11.61 ? 308 PHE A CD1 1 
ATOM   2229 C CD2 . PHE A 1 308 ? 10.048  -2.022  -5.927  1.00 11.42 ? 308 PHE A CD2 1 
ATOM   2230 C CE1 . PHE A 1 308 ? 7.397   -1.332  -6.118  1.00 11.64 ? 308 PHE A CE1 1 
ATOM   2231 C CE2 . PHE A 1 308 ? 9.398   -2.068  -7.152  1.00 11.67 ? 308 PHE A CE2 1 
ATOM   2232 C CZ  . PHE A 1 308 ? 8.094   -1.670  -7.249  1.00 11.66 ? 308 PHE A CZ  1 
ATOM   2233 N N   . PHE A 1 309 ? 11.757  -4.362  -3.275  1.00 10.68 ? 309 PHE A N   1 
ATOM   2234 C CA  . PHE A 1 309 ? 12.418  -5.543  -3.799  1.00 10.10 ? 309 PHE A CA  1 
ATOM   2235 C C   . PHE A 1 309 ? 11.896  -6.803  -3.102  1.00 11.28 ? 309 PHE A C   1 
ATOM   2236 O O   . PHE A 1 309 ? 11.613  -7.822  -3.735  1.00 10.53 ? 309 PHE A O   1 
ATOM   2237 C CB  . PHE A 1 309 ? 13.921  -5.353  -3.629  1.00 9.26  ? 309 PHE A CB  1 
ATOM   2238 C CG  . PHE A 1 309 ? 14.572  -4.334  -4.552  1.00 9.16  ? 309 PHE A CG  1 
ATOM   2239 C CD1 . PHE A 1 309 ? 13.916  -3.792  -5.650  1.00 8.45  ? 309 PHE A CD1 1 
ATOM   2240 C CD2 . PHE A 1 309 ? 15.861  -3.911  -4.292  1.00 8.28  ? 309 PHE A CD2 1 
ATOM   2241 C CE1 . PHE A 1 309 ? 14.564  -2.884  -6.475  1.00 8.45  ? 309 PHE A CE1 1 
ATOM   2242 C CE2 . PHE A 1 309 ? 16.505  -3.009  -5.125  1.00 8.19  ? 309 PHE A CE2 1 
ATOM   2243 C CZ  . PHE A 1 309 ? 15.866  -2.514  -6.220  1.00 8.21  ? 309 PHE A CZ  1 
ATOM   2244 N N   . LYS A 1 310 ? 11.708  -6.714  -1.790  1.00 12.52 ? 310 LYS A N   1 
ATOM   2245 C CA  . LYS A 1 310 ? 11.261  -7.873  -1.039  1.00 14.34 ? 310 LYS A CA  1 
ATOM   2246 C C   . LYS A 1 310 ? 9.830   -8.251  -1.431  1.00 13.69 ? 310 LYS A C   1 
ATOM   2247 O O   . LYS A 1 310 ? 9.466   -9.396  -1.278  1.00 13.90 ? 310 LYS A O   1 
ATOM   2248 C CB  . LYS A 1 310 ? 11.307  -7.613  0.465   1.00 16.98 ? 310 LYS A CB  1 
ATOM   2249 C CG  . LYS A 1 310 ? 12.694  -7.685  1.076   1.00 23.43 ? 310 LYS A CG  1 
ATOM   2250 C CD  . LYS A 1 310 ? 12.670  -7.807  2.591   1.00 28.70 ? 310 LYS A CD  1 
ATOM   2251 C CE  . LYS A 1 310 ? 13.942  -7.307  3.237   1.00 35.67 ? 310 LYS A CE  1 
ATOM   2252 N NZ  . LYS A 1 310 ? 15.143  -7.974  2.679   1.00 36.21 ? 310 LYS A NZ  1 
ATOM   2253 N N   . GLN A 1 311 ? 9.037   -7.292  -1.925  1.00 13.56 ? 311 GLN A N   1 
ATOM   2254 C CA  . GLN A 1 311 ? 7.633   -7.515  -2.282  1.00 15.99 ? 311 GLN A CA  1 
ATOM   2255 C C   . GLN A 1 311 ? 7.519   -8.344  -3.567  1.00 16.87 ? 311 GLN A C   1 
ATOM   2256 O O   . GLN A 1 311 ? 6.538   -9.077  -3.772  1.00 14.78 ? 311 GLN A O   1 
ATOM   2257 C CB  . GLN A 1 311 ? 6.953   -6.140  -2.329  1.00 18.02 ? 311 GLN A CB  1 
ATOM   2258 C CG  . GLN A 1 311 ? 5.435   -6.140  -2.360  1.00 22.29 ? 311 GLN A CG  1 
ATOM   2259 C CD  . GLN A 1 311 ? 4.857   -6.611  -1.044  1.00 24.12 ? 311 GLN A CD  1 
ATOM   2260 O OE1 . GLN A 1 311 ? 5.437   -6.363  0.016   1.00 23.40 ? 311 GLN A OE1 1 
ATOM   2261 N NE2 . GLN A 1 311 ? 3.799   -7.413  -1.117  1.00 22.65 ? 311 GLN A NE2 1 
ATOM   2262 N N   . TRP A 1 312 ? 8.534   -8.253  -4.437  1.00 17.38 ? 312 TRP A N   1 
ATOM   2263 C CA  . TRP A 1 312 ? 8.414   -8.678  -5.829  1.00 20.53 ? 312 TRP A CA  1 
ATOM   2264 C C   . TRP A 1 312 ? 9.516   -9.681  -6.148  1.00 25.38 ? 312 TRP A C   1 
ATOM   2265 O O   . TRP A 1 312 ? 10.676  -9.307  -6.183  1.00 39.62 ? 312 TRP A O   1 
ATOM   2266 C CB  . TRP A 1 312 ? 8.472   -7.447  -6.767  1.00 19.17 ? 312 TRP A CB  1 
ATOM   2267 C CG  . TRP A 1 312 ? 7.453   -6.388  -6.447  1.00 19.03 ? 312 TRP A CG  1 
ATOM   2268 C CD1 . TRP A 1 312 ? 7.672   -5.120  -5.986  1.00 19.08 ? 312 TRP A CD1 1 
ATOM   2269 C CD2 . TRP A 1 312 ? 6.025   -6.522  -6.564  1.00 18.91 ? 312 TRP A CD2 1 
ATOM   2270 N NE1 . TRP A 1 312 ? 6.488   -4.488  -5.752  1.00 20.85 ? 312 TRP A NE1 1 
ATOM   2271 C CE2 . TRP A 1 312 ? 5.459   -5.306  -6.119  1.00 19.73 ? 312 TRP A CE2 1 
ATOM   2272 C CE3 . TRP A 1 312 ? 5.170   -7.536  -7.008  1.00 19.47 ? 312 TRP A CE3 1 
ATOM   2273 C CZ2 . TRP A 1 312 ? 4.089   -5.086  -6.119  1.00 20.51 ? 312 TRP A CZ2 1 
ATOM   2274 C CZ3 . TRP A 1 312 ? 3.807   -7.321  -6.977  1.00 20.93 ? 312 TRP A CZ3 1 
ATOM   2275 C CH2 . TRP A 1 312 ? 3.277   -6.104  -6.559  1.00 20.73 ? 312 TRP A CH2 1 
ATOM   2276 N N   . VAL A 1 313 ? 9.166   -10.939 -6.421  1.00 23.43 ? 313 VAL A N   1 
ATOM   2277 C CA  . VAL A 1 313 ? 10.132  -11.897 -6.923  1.00 25.12 ? 313 VAL A CA  1 
ATOM   2278 C C   . VAL A 1 313 ? 9.868   -12.088 -8.397  1.00 23.15 ? 313 VAL A C   1 
ATOM   2279 O O   . VAL A 1 313 ? 8.812   -11.739 -8.908  1.00 23.02 ? 313 VAL A O   1 
ATOM   2280 C CB  . VAL A 1 313 ? 10.085  -13.273 -6.214  1.00 25.55 ? 313 VAL A CB  1 
ATOM   2281 C CG1 . VAL A 1 313 ? 10.369  -13.159 -4.730  1.00 27.15 ? 313 VAL A CG1 1 
ATOM   2282 C CG2 . VAL A 1 313 ? 8.766   -13.985 -6.469  1.00 28.20 ? 313 VAL A CG2 1 
ATOM   2283 N N   . LEU A 1 314 ? 10.857  -12.666 -9.056  1.00 22.34 ? 314 LEU A N   1 
ATOM   2284 C CA  . LEU A 1 314 ? 10.724  -13.065 -10.428 1.00 22.83 ? 314 LEU A CA  1 
ATOM   2285 C C   . LEU A 1 314 ? 9.788   -14.269 -10.434 1.00 29.74 ? 314 LEU A C   1 
ATOM   2286 O O   . LEU A 1 314 ? 10.078  -15.247 -9.743  1.00 25.20 ? 314 LEU A O   1 
ATOM   2287 C CB  . LEU A 1 314 ? 12.105  -13.419 -10.963 1.00 23.39 ? 314 LEU A CB  1 
ATOM   2288 C CG  . LEU A 1 314 ? 12.168  -13.634 -12.458 1.00 21.89 ? 314 LEU A CG  1 
ATOM   2289 C CD1 . LEU A 1 314 ? 11.902  -12.307 -13.171 1.00 22.77 ? 314 LEU A CD1 1 
ATOM   2290 C CD2 . LEU A 1 314 ? 13.515  -14.194 -12.849 1.00 23.68 ? 314 LEU A CD2 1 
ATOM   2291 N N   . PRO A 1 315 ? 8.609   -14.171 -11.086 1.00 30.65 ? 315 PRO A N   1 
ATOM   2292 C CA  . PRO A 1 315 ? 7.636   -15.263 -11.121 1.00 35.19 ? 315 PRO A CA  1 
ATOM   2293 C C   . PRO A 1 315 ? 8.185   -16.477 -11.860 1.00 35.98 ? 315 PRO A C   1 
ATOM   2294 O O   . PRO A 1 315 ? 8.939   -16.317 -12.811 1.00 32.46 ? 315 PRO A O   1 
ATOM   2295 C CB  . PRO A 1 315 ? 6.425   -14.672 -11.876 1.00 35.77 ? 315 PRO A CB  1 
ATOM   2296 C CG  . PRO A 1 315 ? 6.603   -13.179 -11.741 1.00 35.91 ? 315 PRO A CG  1 
ATOM   2297 C CD  . PRO A 1 315 ? 8.108   -12.986 -11.807 1.00 35.21 ? 315 PRO A CD  1 
ATOM   2298 N N   . GLY A 1 316 ? 7.798   -17.674 -11.395 1.00 40.29 ? 316 GLY A N   1 
ATOM   2299 C CA  . GLY A 1 316 ? 8.119   -18.925 -12.070 1.00 49.50 ? 316 GLY A CA  1 
ATOM   2300 C C   . GLY A 1 316 ? 7.666   -18.911 -13.529 1.00 56.61 ? 316 GLY A C   1 
ATOM   2301 O O   . GLY A 1 316 ? 6.515   -18.585 -13.809 1.00 63.69 ? 316 GLY A O   1 
ATOM   2302 N N   . SER A 1 317 ? 8.587   -19.276 -14.437 1.00 61.39 ? 317 SER A N   1 
ATOM   2303 C CA  . SER A 1 317 ? 8.453   -19.072 -15.876 1.00 64.73 ? 317 SER A CA  1 
ATOM   2304 C C   . SER A 1 317 ? 8.648   -17.584 -16.203 1.00 62.90 ? 317 SER A C   1 
ATOM   2305 O O   . SER A 1 317 ? 8.381   -17.215 -17.367 1.00 65.56 ? 317 SER A O   1 
ATOM   2306 C CB  . SER A 1 317 ? 7.131   -19.590 -16.433 1.00 64.28 ? 317 SER A CB  1 
ATOM   2307 O OG  . SER A 1 317 ? 6.740   -20.809 -15.819 1.00 59.66 ? 317 SER A OG  1 
HETATM 2308 C C1  . NAG B 2 .   ? 42.319  -3.901  -12.407 1.00 35.24 ? 401 NAG A C1  1 
HETATM 2309 C C2  . NAG B 2 .   ? 43.272  -3.843  -11.216 1.00 41.01 ? 401 NAG A C2  1 
HETATM 2310 C C3  . NAG B 2 .   ? 44.036  -2.526  -11.253 1.00 48.37 ? 401 NAG A C3  1 
HETATM 2311 C C4  . NAG B 2 .   ? 44.796  -2.416  -12.564 1.00 49.40 ? 401 NAG A C4  1 
HETATM 2312 C C5  . NAG B 2 .   ? 43.814  -2.505  -13.730 1.00 43.60 ? 401 NAG A C5  1 
HETATM 2313 C C6  . NAG B 2 .   ? 44.550  -2.571  -15.041 1.00 40.50 ? 401 NAG A C6  1 
HETATM 2314 C C7  . NAG B 2 .   ? 42.213  -5.064  -9.370  1.00 38.53 ? 401 NAG A C7  1 
HETATM 2315 C C8  . NAG B 2 .   ? 41.356  -4.936  -8.143  1.00 38.89 ? 401 NAG A C8  1 
HETATM 2316 N N2  . NAG B 2 .   ? 42.590  -3.918  -9.938  1.00 39.04 ? 401 NAG A N2  1 
HETATM 2317 O O3  . NAG B 2 .   ? 44.910  -2.407  -10.139 1.00 53.89 ? 401 NAG A O3  1 
HETATM 2318 O O4  . NAG B 2 .   ? 45.456  -1.153  -12.598 1.00 55.74 ? 401 NAG A O4  1 
HETATM 2319 O O5  . NAG B 2 .   ? 42.991  -3.695  -13.653 1.00 36.76 ? 401 NAG A O5  1 
HETATM 2320 O O6  . NAG B 2 .   ? 43.639  -2.817  -16.094 1.00 39.62 ? 401 NAG A O6  1 
HETATM 2321 O O7  . NAG B 2 .   ? 42.532  -6.155  -9.843  1.00 42.48 ? 401 NAG A O7  1 
HETATM 2322 C C1  . NAG C 2 .   ? 20.369  23.369  1.217   1.00 36.81 ? 402 NAG A C1  1 
HETATM 2323 C C2  . NAG C 2 .   ? 19.882  23.583  -0.215  1.00 40.05 ? 402 NAG A C2  1 
HETATM 2324 C C3  . NAG C 2 .   ? 20.123  25.025  -0.651  1.00 44.18 ? 402 NAG A C3  1 
HETATM 2325 C C4  . NAG C 2 .   ? 19.628  26.021  0.385   1.00 47.19 ? 402 NAG A C4  1 
HETATM 2326 C C5  . NAG C 2 .   ? 20.247  25.720  1.743   1.00 45.59 ? 402 NAG A C5  1 
HETATM 2327 C C6  . NAG C 2 .   ? 19.734  26.647  2.826   1.00 42.62 ? 402 NAG A C6  1 
HETATM 2328 C C7  . NAG C 2 .   ? 19.874  21.569  -1.676  1.00 44.18 ? 402 NAG A C7  1 
HETATM 2329 C C8  . NAG C 2 .   ? 20.665  20.757  -2.660  1.00 46.23 ? 402 NAG A C8  1 
HETATM 2330 N N2  . NAG C 2 .   ? 20.478  22.659  -1.170  1.00 40.77 ? 402 NAG A N2  1 
HETATM 2331 O O3  . NAG C 2 .   ? 19.452  25.243  -1.878  1.00 43.25 ? 402 NAG A O3  1 
HETATM 2332 O O4  . NAG C 2 .   ? 20.017  27.331  -0.010  1.00 52.79 ? 402 NAG A O4  1 
HETATM 2333 O O5  . NAG C 2 .   ? 19.901  24.372  2.120   1.00 40.32 ? 402 NAG A O5  1 
HETATM 2334 O O6  . NAG C 2 .   ? 20.377  26.401  4.082   1.00 44.94 ? 402 NAG A O6  1 
HETATM 2335 O O7  . NAG C 2 .   ? 18.735  21.241  -1.353  1.00 46.03 ? 402 NAG A O7  1 
HETATM 2336 C C   . ACT D 3 .   ? 2.828   15.192  -17.598 1.00 35.63 ? 403 ACT A C   1 
HETATM 2337 O O   . ACT D 3 .   ? 3.352   14.430  -18.429 1.00 33.72 ? 403 ACT A O   1 
HETATM 2338 O OXT . ACT D 3 .   ? 1.594   15.197  -17.351 1.00 38.26 ? 403 ACT A OXT 1 
HETATM 2339 C CH3 . ACT D 3 .   ? 3.724   16.184  -16.847 1.00 34.18 ? 403 ACT A CH3 1 
HETATM 2340 C C1  . SIN E 4 .   ? 24.226  12.496  -11.019 1.00 26.10 ? 404 SIN A C1  1 
HETATM 2341 O O1  . SIN E 4 .   ? 25.237  12.110  -10.396 1.00 26.12 ? 404 SIN A O1  1 
HETATM 2342 O O2  . SIN E 4 .   ? 23.100  12.386  -10.472 1.00 18.89 ? 404 SIN A O2  1 
HETATM 2343 C C2  . SIN E 4 .   ? 24.459  13.192  -12.388 1.00 22.06 ? 404 SIN A C2  1 
HETATM 2344 C C3  . SIN E 4 .   ? 23.416  13.318  -13.604 1.00 20.10 ? 404 SIN A C3  1 
HETATM 2345 C C4  . SIN E 4 .   ? 23.415  12.231  -14.717 1.00 20.38 ? 404 SIN A C4  1 
HETATM 2346 O O3  . SIN E 4 .   ? 23.147  12.443  -16.007 1.00 21.05 ? 404 SIN A O3  1 
HETATM 2347 O O4  . SIN E 4 .   ? 23.546  11.122  -14.321 1.00 14.50 ? 404 SIN A O4  1 
HETATM 2348 O O   . HOH F 5 .   ? 24.234  -13.932 -20.037 1.00 20.95 ? 501 HOH A O   1 
HETATM 2349 O O   . HOH F 5 .   ? 21.834  -19.255 5.912   1.00 38.43 ? 502 HOH A O   1 
HETATM 2350 O O   . HOH F 5 .   ? 36.872  -4.025  -25.531 1.00 25.65 ? 503 HOH A O   1 
HETATM 2351 O O   . HOH F 5 .   ? 9.267   7.016   4.460   1.00 22.83 ? 504 HOH A O   1 
HETATM 2352 O O   . HOH F 5 .   ? -4.364  -3.453  -7.663  1.00 37.40 ? 505 HOH A O   1 
HETATM 2353 O O   . HOH F 5 .   ? 6.263   -11.064 -14.806 1.00 16.44 ? 506 HOH A O   1 
HETATM 2354 O O   . HOH F 5 .   ? -0.784  16.397  -3.640  1.00 23.72 ? 507 HOH A O   1 
HETATM 2355 O O   . HOH F 5 .   ? 15.216  21.106  -20.438 1.00 26.78 ? 508 HOH A O   1 
HETATM 2356 O O   . HOH F 5 .   ? 23.944  -9.699  7.036   1.00 14.94 ? 509 HOH A O   1 
HETATM 2357 O O   . HOH F 5 .   ? 24.991  8.352   2.052   1.00 30.53 ? 510 HOH A O   1 
HETATM 2358 O O   . HOH F 5 .   ? 19.794  9.144   6.132   1.00 15.28 ? 511 HOH A O   1 
HETATM 2359 O O   . HOH F 5 .   ? 5.113   17.400  -3.362  1.00 24.40 ? 512 HOH A O   1 
HETATM 2360 O O   . HOH F 5 .   ? 2.554   20.502  4.515   1.00 17.22 ? 513 HOH A O   1 
HETATM 2361 O O   . HOH F 5 .   ? 3.051   1.946   -22.140 1.00 35.24 ? 514 HOH A O   1 
HETATM 2362 O O   . HOH F 5 .   ? 16.826  23.993  -34.598 1.00 23.70 ? 515 HOH A O   1 
HETATM 2363 O O   . HOH F 5 .   ? 22.318  14.300  -18.239 1.00 17.68 ? 516 HOH A O   1 
HETATM 2364 O O   . HOH F 5 .   ? 10.520  -11.387 -0.085  1.00 30.31 ? 517 HOH A O   1 
HETATM 2365 O O   . HOH F 5 .   ? 15.490  -9.799  6.554   1.00 37.66 ? 518 HOH A O   1 
HETATM 2366 O O   . HOH F 5 .   ? 24.451  -25.885 -1.078  1.00 27.26 ? 519 HOH A O   1 
HETATM 2367 O O   . HOH F 5 .   ? 17.692  -14.167 -12.476 1.00 17.60 ? 520 HOH A O   1 
HETATM 2368 O O   . HOH F 5 .   ? 15.403  14.326  -8.571  1.00 11.29 ? 521 HOH A O   1 
HETATM 2369 O O   . HOH F 5 .   ? 34.141  -11.226 -11.418 1.00 18.71 ? 522 HOH A O   1 
HETATM 2370 O O   . HOH F 5 .   ? 1.862   -6.586  -17.266 1.00 33.61 ? 523 HOH A O   1 
HETATM 2371 O O   . HOH F 5 .   ? 40.783  -7.145  -22.168 1.00 23.78 ? 524 HOH A O   1 
HETATM 2372 O O   . HOH F 5 .   ? 28.013  -15.444 7.399   1.00 25.61 ? 525 HOH A O   1 
HETATM 2373 O O   . HOH F 5 .   ? 31.052  10.930  -18.221 1.00 39.87 ? 526 HOH A O   1 
HETATM 2374 O O   . HOH F 5 .   ? 22.347  -16.582 5.104   1.00 20.16 ? 527 HOH A O   1 
HETATM 2375 O O   . HOH F 5 .   ? 13.190  -1.845  4.222   1.00 14.73 ? 528 HOH A O   1 
HETATM 2376 O O   . HOH F 5 .   ? 17.437  -3.420  -25.030 1.00 18.27 ? 529 HOH A O   1 
HETATM 2377 O O   . HOH F 5 .   ? 11.047  13.599  7.659   1.00 23.01 ? 530 HOH A O   1 
HETATM 2378 O O   . HOH F 5 .   ? 6.484   -11.297 -7.826  1.00 26.67 ? 531 HOH A O   1 
HETATM 2379 O O   . HOH F 5 .   ? 2.764   -3.508  -3.123  1.00 33.88 ? 532 HOH A O   1 
HETATM 2380 O O   . HOH F 5 .   ? 27.190  -11.068 -23.253 1.00 16.93 ? 533 HOH A O   1 
HETATM 2381 O O   . HOH F 5 .   ? 36.746  -11.411 -12.148 1.00 16.74 ? 534 HOH A O   1 
HETATM 2382 O O   . HOH F 5 .   ? 35.210  2.333   -9.707  1.00 22.24 ? 535 HOH A O   1 
HETATM 2383 O O   . HOH F 5 .   ? 28.513  9.314   -2.192  1.00 11.99 ? 536 HOH A O   1 
HETATM 2384 O O   . HOH F 5 .   ? 31.924  -13.340 -26.984 1.00 21.75 ? 537 HOH A O   1 
HETATM 2385 O O   . HOH F 5 .   ? 11.496  7.369   -28.503 1.00 32.12 ? 538 HOH A O   1 
HETATM 2386 O O   . HOH F 5 .   ? 33.182  -18.966 -5.189  1.00 23.96 ? 539 HOH A O   1 
HETATM 2387 O O   . HOH F 5 .   ? 27.175  -17.035 -19.162 1.00 19.92 ? 540 HOH A O   1 
HETATM 2388 O O   . HOH F 5 .   ? 30.380  9.400   -27.596 1.00 16.83 ? 541 HOH A O   1 
HETATM 2389 O O   . HOH F 5 .   ? 14.136  6.815   -28.140 1.00 32.98 ? 542 HOH A O   1 
HETATM 2390 O O   . HOH F 5 .   ? 15.037  -15.129 -20.435 1.00 36.28 ? 543 HOH A O   1 
HETATM 2391 O O   . HOH F 5 .   ? 11.782  20.035  0.176   1.00 16.05 ? 544 HOH A O   1 
HETATM 2392 O O   . HOH F 5 .   ? 12.186  5.667   4.377   1.00 19.14 ? 545 HOH A O   1 
HETATM 2393 O O   . HOH F 5 .   ? 17.490  19.415  -2.806  1.00 34.52 ? 546 HOH A O   1 
HETATM 2394 O O   . HOH F 5 .   ? 22.373  24.160  4.304   1.00 18.73 ? 547 HOH A O   1 
HETATM 2395 O O   . HOH F 5 .   ? 21.662  7.986   3.226   1.00 28.70 ? 548 HOH A O   1 
HETATM 2396 O O   . HOH F 5 .   ? 17.978  -7.181  2.770   1.00 17.56 ? 549 HOH A O   1 
HETATM 2397 O O   . HOH F 5 .   ? 14.266  4.216   -23.404 1.00 23.83 ? 550 HOH A O   1 
HETATM 2398 O O   . HOH F 5 .   ? -1.072  14.523  -6.996  1.00 24.93 ? 551 HOH A O   1 
HETATM 2399 O O   . HOH F 5 .   ? 18.379  6.346   -23.073 1.00 25.46 ? 552 HOH A O   1 
HETATM 2400 O O   . HOH F 5 .   ? 13.618  18.084  0.180   1.00 19.00 ? 553 HOH A O   1 
HETATM 2401 O O   . HOH F 5 .   ? 27.772  8.806   -6.308  1.00 14.77 ? 554 HOH A O   1 
HETATM 2402 O O   . HOH F 5 .   ? 20.768  8.502   -25.677 1.00 21.40 ? 555 HOH A O   1 
HETATM 2403 O O   . HOH F 5 .   ? 16.119  15.456  6.746   1.00 17.72 ? 556 HOH A O   1 
HETATM 2404 O O   . HOH F 5 .   ? 15.490  -1.808  5.407   1.00 22.23 ? 557 HOH A O   1 
HETATM 2405 O O   . HOH F 5 .   ? 30.986  -9.890  -24.241 1.00 10.19 ? 558 HOH A O   1 
HETATM 2406 O O   . HOH F 5 .   ? 22.036  -13.255 3.046   1.00 15.86 ? 559 HOH A O   1 
HETATM 2407 O O   . HOH F 5 .   ? 26.525  2.621   -25.138 1.00 13.20 ? 560 HOH A O   1 
HETATM 2408 O O   . HOH F 5 .   ? 1.632   9.379   -20.732 1.00 20.32 ? 561 HOH A O   1 
HETATM 2409 O O   . HOH F 5 .   ? 21.511  -13.070 -20.252 1.00 21.37 ? 562 HOH A O   1 
HETATM 2410 O O   . HOH F 5 .   ? 22.487  -3.575  -25.215 1.00 19.21 ? 563 HOH A O   1 
HETATM 2411 O O   . HOH F 5 .   ? 15.508  23.196  -25.982 1.00 14.63 ? 564 HOH A O   1 
HETATM 2412 O O   . HOH F 5 .   ? 29.471  4.167   -21.673 1.00 17.22 ? 565 HOH A O   1 
HETATM 2413 O O   . HOH F 5 .   ? 7.850   -6.130  1.173   1.00 13.80 ? 566 HOH A O   1 
HETATM 2414 O O   . HOH F 5 .   ? 16.599  -1.463  -23.241 1.00 13.05 ? 567 HOH A O   1 
HETATM 2415 O O   . HOH F 5 .   ? 25.203  15.930  -26.000 1.00 20.84 ? 568 HOH A O   1 
HETATM 2416 O O   . HOH F 5 .   ? 30.008  -18.550 -2.286  1.00 17.55 ? 569 HOH A O   1 
HETATM 2417 O O   . HOH F 5 .   ? 9.293   -17.067 -7.922  1.00 26.41 ? 570 HOH A O   1 
HETATM 2418 O O   . HOH F 5 .   ? 8.877   -9.472  -10.616 1.00 9.91  ? 571 HOH A O   1 
HETATM 2419 O O   . HOH F 5 .   ? 6.660   4.124   1.950   1.00 21.40 ? 572 HOH A O   1 
HETATM 2420 O O   . HOH F 5 .   ? 33.866  -1.058  -15.718 1.00 9.35  ? 573 HOH A O   1 
HETATM 2421 O O   . HOH F 5 .   ? 3.555   1.911   0.123   1.00 27.87 ? 574 HOH A O   1 
HETATM 2422 O O   . HOH F 5 .   ? 31.726  -1.101  2.010   1.00 16.19 ? 575 HOH A O   1 
HETATM 2423 O O   . HOH F 5 .   ? 29.340  -17.141 -17.674 1.00 13.59 ? 576 HOH A O   1 
HETATM 2424 O O   . HOH F 5 .   ? 31.202  5.889   -22.522 1.00 17.40 ? 577 HOH A O   1 
HETATM 2425 O O   . HOH F 5 .   ? 29.505  2.372   -19.438 1.00 9.62  ? 578 HOH A O   1 
HETATM 2426 O O   . HOH F 5 .   ? 26.966  17.243  -4.829  1.00 27.94 ? 579 HOH A O   1 
HETATM 2427 O O   . HOH F 5 .   ? 37.502  -6.434  -27.220 1.00 22.37 ? 580 HOH A O   1 
HETATM 2428 O O   . HOH F 5 .   ? 24.308  19.673  -3.638  1.00 32.52 ? 581 HOH A O   1 
HETATM 2429 O O   . HOH F 5 .   ? 13.269  21.214  -26.016 1.00 35.20 ? 582 HOH A O   1 
HETATM 2430 O O   . HOH F 5 .   ? 4.126   -9.956  -2.868  1.00 19.04 ? 583 HOH A O   1 
HETATM 2431 O O   . HOH F 5 .   ? 6.850   1.813   -1.922  1.00 12.37 ? 584 HOH A O   1 
HETATM 2432 O O   . HOH F 5 .   ? 4.671   0.444   -3.391  1.00 12.64 ? 585 HOH A O   1 
HETATM 2433 O O   . HOH F 5 .   ? 33.520  13.180  -12.707 1.00 19.64 ? 586 HOH A O   1 
HETATM 2434 O O   . HOH F 5 .   ? 26.941  12.871  -5.315  1.00 28.40 ? 587 HOH A O   1 
HETATM 2435 O O   . HOH F 5 .   ? 16.461  22.559  -15.785 1.00 16.28 ? 588 HOH A O   1 
HETATM 2436 O O   . HOH F 5 .   ? 20.681  8.057   -18.998 1.00 10.86 ? 589 HOH A O   1 
HETATM 2437 O O   . HOH F 5 .   ? 12.083  19.590  -11.891 1.00 11.65 ? 590 HOH A O   1 
HETATM 2438 O O   . HOH F 5 .   ? 22.543  10.238  -18.295 1.00 9.46  ? 591 HOH A O   1 
HETATM 2439 O O   . HOH F 5 .   ? 33.875  9.186   -7.283  1.00 33.46 ? 592 HOH A O   1 
HETATM 2440 O O   . HOH F 5 .   ? 29.911  -4.781  -23.283 1.00 11.25 ? 593 HOH A O   1 
HETATM 2441 O O   . HOH F 5 .   ? 27.688  1.953   -9.472  1.00 8.60  ? 594 HOH A O   1 
HETATM 2442 O O   . HOH F 5 .   ? 34.016  10.845  -9.945  1.00 20.99 ? 595 HOH A O   1 
HETATM 2443 O O   . HOH F 5 .   ? 13.347  -11.451 -0.043  1.00 24.75 ? 596 HOH A O   1 
HETATM 2444 O O   . HOH F 5 .   ? 4.842   -2.465  -15.252 1.00 17.67 ? 597 HOH A O   1 
HETATM 2445 O O   . HOH F 5 .   ? 33.451  9.428   -2.312  1.00 24.17 ? 598 HOH A O   1 
HETATM 2446 O O   . HOH F 5 .   ? 20.608  14.371  1.847   1.00 9.71  ? 599 HOH A O   1 
HETATM 2447 O O   . HOH F 5 .   ? 33.581  -6.542  -24.726 1.00 15.27 ? 600 HOH A O   1 
HETATM 2448 O O   . HOH F 5 .   ? 14.996  11.450  -6.127  1.00 10.92 ? 601 HOH A O   1 
HETATM 2449 O O   . HOH F 5 .   ? 26.472  1.237   1.318   1.00 6.91  ? 602 HOH A O   1 
HETATM 2450 O O   . HOH F 5 .   ? 20.187  -8.591  -23.476 1.00 26.82 ? 603 HOH A O   1 
HETATM 2451 O O   . HOH F 5 .   ? 12.896  13.817  -17.060 1.00 10.38 ? 604 HOH A O   1 
HETATM 2452 O O   . HOH F 5 .   ? 10.833  -17.178 -5.705  1.00 25.58 ? 605 HOH A O   1 
HETATM 2453 O O   . HOH F 5 .   ? 8.463   -0.016  -0.475  1.00 10.72 ? 606 HOH A O   1 
HETATM 2454 O O   . HOH F 5 .   ? 23.869  5.110   -25.453 1.00 19.98 ? 607 HOH A O   1 
HETATM 2455 O O   . HOH F 5 .   ? 30.401  -14.231 -19.640 1.00 14.63 ? 608 HOH A O   1 
HETATM 2456 O O   . HOH F 5 .   ? 21.139  6.352   1.228   1.00 18.90 ? 609 HOH A O   1 
HETATM 2457 O O   . HOH F 5 .   ? -7.666  4.178   -10.258 1.00 33.69 ? 610 HOH A O   1 
HETATM 2458 O O   . HOH F 5 .   ? 32.489  3.001   -1.253  1.00 18.12 ? 611 HOH A O   1 
HETATM 2459 O O   . HOH F 5 .   ? 23.712  19.799  -12.909 1.00 31.41 ? 612 HOH A O   1 
HETATM 2460 O O   . HOH F 5 .   ? 30.005  -14.467 -16.975 1.00 10.35 ? 613 HOH A O   1 
HETATM 2461 O O   . HOH F 5 .   ? 23.204  -16.074 2.517   1.00 22.48 ? 614 HOH A O   1 
HETATM 2462 O O   . HOH F 5 .   ? 0.016   11.057  -14.707 1.00 38.96 ? 615 HOH A O   1 
HETATM 2463 O O   . HOH F 5 .   ? 39.596  -3.571  -21.749 1.00 19.02 ? 616 HOH A O   1 
HETATM 2464 O O   . HOH F 5 .   ? 25.115  -25.973 -6.220  1.00 27.31 ? 617 HOH A O   1 
HETATM 2465 O O   . HOH F 5 .   ? 18.254  6.503   1.186   1.00 11.04 ? 618 HOH A O   1 
HETATM 2466 O O   . HOH F 5 .   ? 4.848   17.917  -23.904 1.00 21.61 ? 619 HOH A O   1 
HETATM 2467 O O   . HOH F 5 .   ? 20.125  19.149  -7.083  1.00 23.27 ? 620 HOH A O   1 
HETATM 2468 O O   . HOH F 5 .   ? 18.631  13.739  -0.025  1.00 8.44  ? 621 HOH A O   1 
HETATM 2469 O O   . HOH F 5 .   ? 23.203  -21.126 -11.715 1.00 18.01 ? 622 HOH A O   1 
HETATM 2470 O O   . HOH F 5 .   ? 41.365  -8.117  -19.500 1.00 15.24 ? 623 HOH A O   1 
HETATM 2471 O O   . HOH F 5 .   ? 8.650   14.441  -28.626 1.00 19.89 ? 624 HOH A O   1 
HETATM 2472 O O   . HOH F 5 .   ? 11.278  -14.473 -16.067 1.00 21.70 ? 625 HOH A O   1 
HETATM 2473 O O   . HOH F 5 .   ? 31.207  5.994   -25.417 1.00 18.02 ? 626 HOH A O   1 
HETATM 2474 O O   . HOH F 5 .   ? 33.753  -11.526 -7.101  1.00 26.31 ? 627 HOH A O   1 
HETATM 2475 O O   . HOH F 5 .   ? 31.914  -7.551  1.657   1.00 18.06 ? 628 HOH A O   1 
HETATM 2476 O O   . HOH F 5 .   ? 22.812  -17.334 -18.212 1.00 31.32 ? 629 HOH A O   1 
HETATM 2477 O O   . HOH F 5 .   ? 38.473  -1.460  -20.432 1.00 26.64 ? 630 HOH A O   1 
HETATM 2478 O O   . HOH F 5 .   ? 14.026  14.427  -33.456 1.00 19.98 ? 631 HOH A O   1 
HETATM 2479 O O   . HOH F 5 .   ? 5.873   5.756   -24.992 1.00 36.74 ? 632 HOH A O   1 
HETATM 2480 O O   . HOH F 5 .   ? 10.528  20.223  -14.169 1.00 12.08 ? 633 HOH A O   1 
HETATM 2481 O O   . HOH F 5 .   ? 29.925  14.518  -11.670 1.00 25.08 ? 634 HOH A O   1 
HETATM 2482 O O   . HOH F 5 .   ? 39.757  -1.345  -13.127 1.00 26.04 ? 635 HOH A O   1 
HETATM 2483 O O   . HOH F 5 .   ? 12.927  7.680   6.009   1.00 19.07 ? 636 HOH A O   1 
HETATM 2484 O O   . HOH F 5 .   ? 9.082   1.090   -27.378 1.00 28.07 ? 637 HOH A O   1 
HETATM 2485 O O   . HOH F 5 .   ? 25.828  8.413   -8.052  1.00 8.25  ? 638 HOH A O   1 
HETATM 2486 O O   . HOH F 5 .   ? 15.248  4.722   -20.492 1.00 30.20 ? 639 HOH A O   1 
HETATM 2487 O O   . HOH F 5 .   ? 16.543  18.648  0.566   1.00 22.27 ? 640 HOH A O   1 
HETATM 2488 O O   . HOH F 5 .   ? -0.457  5.454   -2.967  1.00 20.99 ? 641 HOH A O   1 
HETATM 2489 O O   . HOH F 5 .   ? 37.632  -0.938  -16.901 1.00 26.21 ? 642 HOH A O   1 
HETATM 2490 O O   . HOH F 5 .   ? 36.369  1.606   -6.238  1.00 19.65 ? 643 HOH A O   1 
HETATM 2491 O O   . HOH F 5 .   ? 6.078   18.586  -18.857 1.00 34.78 ? 644 HOH A O   1 
HETATM 2492 O O   . HOH F 5 .   ? 19.015  -15.559 -14.313 1.00 19.72 ? 645 HOH A O   1 
HETATM 2493 O O   . HOH F 5 .   ? 30.456  -3.099  -25.281 1.00 15.57 ? 646 HOH A O   1 
HETATM 2494 O O   . HOH F 5 .   ? 18.608  20.117  -9.159  1.00 25.37 ? 647 HOH A O   1 
HETATM 2495 O O   . HOH F 5 .   ? 21.474  16.703  -17.437 1.00 13.40 ? 648 HOH A O   1 
HETATM 2496 O O   . HOH F 5 .   ? 24.944  10.963  -7.778  1.00 12.21 ? 649 HOH A O   1 
HETATM 2497 O O   . HOH F 5 .   ? 4.932   20.854  5.790   1.00 22.37 ? 650 HOH A O   1 
HETATM 2498 O O   . HOH F 5 .   ? 26.842  2.400   5.898   1.00 27.34 ? 651 HOH A O   1 
HETATM 2499 O O   . HOH F 5 .   ? 28.874  -20.171 4.478   1.00 18.49 ? 652 HOH A O   1 
HETATM 2500 O O   . HOH F 5 .   ? 23.984  14.843  -7.914  1.00 25.61 ? 653 HOH A O   1 
HETATM 2501 O O   . HOH F 5 .   ? 20.189  -20.153 -11.076 1.00 37.43 ? 654 HOH A O   1 
HETATM 2502 O O   . HOH F 5 .   ? 11.629  9.611   7.259   1.00 23.10 ? 655 HOH A O   1 
HETATM 2503 O O   . HOH F 5 .   ? 14.215  11.370  -17.313 1.00 7.29  ? 656 HOH A O   1 
HETATM 2504 O O   . HOH F 5 .   ? 35.038  3.297   -7.221  1.00 11.74 ? 657 HOH A O   1 
HETATM 2505 O O   . HOH F 5 .   ? 25.605  3.373   -29.122 1.00 26.08 ? 658 HOH A O   1 
HETATM 2506 O O   . HOH F 5 .   ? 36.603  4.309   -18.689 1.00 19.60 ? 659 HOH A O   1 
HETATM 2507 O O   . HOH F 5 .   ? 25.342  -18.364 -14.534 1.00 16.54 ? 660 HOH A O   1 
HETATM 2508 O O   . HOH F 5 .   ? 15.495  -12.027 -10.326 1.00 11.93 ? 661 HOH A O   1 
HETATM 2509 O O   . HOH F 5 .   ? 17.420  -8.543  -25.105 1.00 27.56 ? 662 HOH A O   1 
HETATM 2510 O O   . HOH F 5 .   ? 20.496  5.461   -19.524 1.00 12.16 ? 663 HOH A O   1 
HETATM 2511 O O   . HOH F 5 .   ? 31.232  -16.896 -24.152 1.00 19.53 ? 664 HOH A O   1 
HETATM 2512 O O   . HOH F 5 .   ? 2.987   20.317  -0.132  1.00 26.29 ? 665 HOH A O   1 
HETATM 2513 O O   . HOH F 5 .   ? 28.741  4.910   4.152   1.00 23.88 ? 666 HOH A O   1 
HETATM 2514 O O   . HOH F 5 .   ? 5.690   18.585  -9.925  1.00 23.84 ? 667 HOH A O   1 
HETATM 2515 O O   . HOH F 5 .   ? 9.691   22.437  -6.939  1.00 25.98 ? 668 HOH A O   1 
HETATM 2516 O O   . HOH F 5 .   ? 39.207  -3.778  -2.868  1.00 18.25 ? 669 HOH A O   1 
HETATM 2517 O O   . HOH F 5 .   ? -3.141  10.262  2.056   1.00 17.23 ? 670 HOH A O   1 
HETATM 2518 O O   . HOH F 5 .   ? 7.908   20.127  -10.537 1.00 31.64 ? 671 HOH A O   1 
HETATM 2519 O O   . HOH F 5 .   ? 16.955  20.549  -31.779 1.00 22.48 ? 672 HOH A O   1 
HETATM 2520 O O   . HOH F 5 .   ? 17.965  -1.688  11.123  1.00 36.80 ? 673 HOH A O   1 
HETATM 2521 O O   . HOH F 5 .   ? 4.122   10.235  6.356   1.00 19.29 ? 674 HOH A O   1 
HETATM 2522 O O   . HOH F 5 .   ? 26.946  10.036  0.032   1.00 10.81 ? 675 HOH A O   1 
HETATM 2523 O O   . HOH F 5 .   ? 32.909  -2.066  -24.330 1.00 15.64 ? 676 HOH A O   1 
HETATM 2524 O O   . HOH F 5 .   ? 22.375  8.400   -27.936 1.00 44.45 ? 677 HOH A O   1 
HETATM 2525 O O   . HOH F 5 .   ? 18.870  18.739  -30.620 1.00 21.58 ? 678 HOH A O   1 
HETATM 2526 O O   . HOH F 5 .   ? 20.642  -5.859  -25.482 1.00 24.12 ? 679 HOH A O   1 
HETATM 2527 O O   . HOH F 5 .   ? 26.574  -2.086  8.006   1.00 22.00 ? 680 HOH A O   1 
HETATM 2528 O O   . HOH F 5 .   ? 16.831  -4.893  8.799   1.00 34.18 ? 681 HOH A O   1 
HETATM 2529 O O   . HOH F 5 .   ? 31.918  -3.194  -22.079 1.00 11.28 ? 682 HOH A O   1 
HETATM 2530 O O   . HOH F 5 .   ? 2.219   12.913  7.535   1.00 28.80 ? 683 HOH A O   1 
HETATM 2531 O O   . HOH F 5 .   ? 22.942  16.744  -6.633  1.00 23.87 ? 684 HOH A O   1 
HETATM 2532 O O   . HOH F 5 .   ? 32.896  -19.489 2.321   1.00 17.67 ? 685 HOH A O   1 
HETATM 2533 O O   . HOH F 5 .   ? 35.113  4.201   -24.207 1.00 37.46 ? 686 HOH A O   1 
HETATM 2534 O O   . HOH F 5 .   ? 17.786  22.079  -7.472  1.00 40.44 ? 687 HOH A O   1 
HETATM 2535 O O   . HOH F 5 .   ? 28.688  16.713  -20.729 1.00 18.92 ? 688 HOH A O   1 
HETATM 2536 O O   . HOH F 5 .   ? -11.681 -8.905  -13.434 1.00 35.86 ? 689 HOH A O   1 
HETATM 2537 O O   . HOH F 5 .   ? 14.899  0.216   -24.645 1.00 20.78 ? 690 HOH A O   1 
HETATM 2538 O O   . HOH F 5 .   ? 33.162  3.938   -26.509 1.00 36.63 ? 691 HOH A O   1 
HETATM 2539 O O   . HOH F 5 .   ? 23.498  23.505  -1.338  1.00 33.35 ? 692 HOH A O   1 
HETATM 2540 O O   . HOH F 5 .   ? -2.293  -0.003  -6.792  1.00 30.40 ? 693 HOH A O   1 
HETATM 2541 O O   . HOH F 5 .   ? 25.323  19.100  6.608   1.00 31.05 ? 694 HOH A O   1 
HETATM 2542 O O   . HOH F 5 .   ? 5.103   -4.497  -21.636 1.00 33.05 ? 695 HOH A O   1 
HETATM 2543 O O   . HOH F 5 .   ? 19.073  -5.902  10.008  1.00 23.88 ? 696 HOH A O   1 
HETATM 2544 O O   . HOH F 5 .   ? 27.756  15.225  -6.050  1.00 33.99 ? 697 HOH A O   1 
HETATM 2545 O O   . HOH F 5 .   ? 27.819  9.081   -28.860 1.00 26.08 ? 698 HOH A O   1 
HETATM 2546 O O   . HOH F 5 .   ? 14.406  -9.674  -1.477  1.00 21.92 ? 699 HOH A O   1 
HETATM 2547 O O   . HOH F 5 .   ? 10.303  -14.744 -18.436 1.00 31.58 ? 700 HOH A O   1 
HETATM 2548 O O   . HOH F 5 .   ? 17.907  5.754   -20.598 1.00 27.24 ? 701 HOH A O   1 
HETATM 2549 O O   . HOH F 5 .   ? 13.705  -1.274  -26.295 1.00 36.54 ? 702 HOH A O   1 
HETATM 2550 O O   . HOH F 5 .   ? 12.213  23.300  -11.569 1.00 36.09 ? 703 HOH A O   1 
HETATM 2551 O O   . HOH F 5 .   ? 42.476  -8.446  -12.940 1.00 23.96 ? 704 HOH A O   1 
HETATM 2552 O O   . HOH F 5 .   ? 40.075  -6.893  -26.294 1.00 24.48 ? 705 HOH A O   1 
HETATM 2553 O O   . HOH F 5 .   ? 24.815  2.817   -26.765 1.00 36.12 ? 706 HOH A O   1 
HETATM 2554 O O   . HOH F 5 .   ? 4.996   -2.193  -3.419  1.00 25.00 ? 707 HOH A O   1 
HETATM 2555 O O   . HOH F 5 .   ? 10.258  1.350   4.011   1.00 25.98 ? 708 HOH A O   1 
HETATM 2556 O O   . HOH F 5 .   ? 12.495  -4.511  3.891   1.00 24.63 ? 709 HOH A O   1 
HETATM 2557 O O   . HOH F 5 .   ? 7.941   20.423  -13.279 1.00 34.24 ? 710 HOH A O   1 
HETATM 2558 O O   . HOH F 5 .   ? 9.319   -2.411  6.915   1.00 36.43 ? 711 HOH A O   1 
HETATM 2559 O O   . HOH F 5 .   ? 6.895   -2.246  -0.839  1.00 17.37 ? 712 HOH A O   1 
HETATM 2560 O O   . HOH F 5 .   ? 5.190   20.681  -1.352  1.00 41.54 ? 713 HOH A O   1 
HETATM 2561 O O   . HOH F 5 .   ? 19.594  -10.444 9.650   1.00 24.45 ? 714 HOH A O   1 
HETATM 2562 O O   . HOH F 5 .   ? 15.141  -0.415  7.729   1.00 25.55 ? 715 HOH A O   1 
HETATM 2563 O O   . HOH F 5 .   ? 32.241  7.438   -27.386 1.00 35.21 ? 716 HOH A O   1 
HETATM 2564 O O   . HOH F 5 .   ? 8.420   -6.838  3.651   1.00 27.98 ? 717 HOH A O   1 
HETATM 2565 O O   . HOH F 5 .   ? 29.407  3.183   2.332   1.00 23.58 ? 718 HOH A O   1 
HETATM 2566 O O   . HOH F 5 .   ? 2.763   21.726  2.139   1.00 17.92 ? 719 HOH A O   1 
HETATM 2567 O O   . HOH F 5 .   ? 33.676  -5.748  -27.800 1.00 21.91 ? 720 HOH A O   1 
HETATM 2568 O O   . HOH F 5 .   ? 32.127  2.997   1.492   1.00 23.20 ? 721 HOH A O   1 
HETATM 2569 O O   . HOH F 5 .   ? 31.738  11.354  -28.487 1.00 23.20 ? 722 HOH A O   1 
HETATM 2570 O O   . HOH F 5 .   ? 27.927  1.358   3.551   1.00 20.64 ? 723 HOH A O   1 
HETATM 2571 O O   . HOH F 5 .   ? 40.706  -0.608  -11.175 1.00 30.72 ? 724 HOH A O   1 
HETATM 2572 O O   . HOH F 5 .   ? 19.758  -15.029 -20.826 1.00 31.61 ? 725 HOH A O   1 
HETATM 2573 O O   . HOH F 5 .   ? 11.005  -0.672  5.691   1.00 24.91 ? 726 HOH A O   1 
HETATM 2574 O O   . HOH F 5 .   ? 29.918  -11.209 -26.359 1.00 19.83 ? 727 HOH A O   1 
HETATM 2575 O O   . HOH F 5 .   ? 20.718  -24.375 -3.875  1.00 32.95 ? 728 HOH A O   1 
HETATM 2576 O O   . HOH F 5 .   ? 2.335   -2.370  -0.670  1.00 38.21 ? 729 HOH A O   1 
HETATM 2577 O O   . HOH F 5 .   ? 18.763  4.586   -24.819 1.00 23.87 ? 730 HOH A O   1 
HETATM 2578 O O   . HOH F 5 .   ? 36.091  0.457   -15.528 1.00 12.50 ? 731 HOH A O   1 
HETATM 2579 O O   . HOH F 5 .   ? 22.866  18.721  -8.501  1.00 41.09 ? 732 HOH A O   1 
HETATM 2580 O O   . HOH F 5 .   ? 2.556   -10.142 -4.770  1.00 32.87 ? 733 HOH A O   1 
HETATM 2581 O O   . HOH F 5 .   ? 7.791   1.264   2.091   1.00 22.41 ? 734 HOH A O   1 
HETATM 2582 O O   . HOH F 5 .   ? 34.283  -0.055  -24.972 1.00 25.79 ? 735 HOH A O   1 
HETATM 2583 O O   . HOH F 5 .   ? 10.794  3.560   5.144   1.00 28.12 ? 736 HOH A O   1 
HETATM 2584 O O   . HOH F 5 .   ? 37.555  2.033   -10.969 1.00 21.59 ? 737 HOH A O   1 
HETATM 2585 O O   . HOH F 5 .   ? 30.814  -7.071  -24.539 1.00 10.82 ? 738 HOH A O   1 
HETATM 2586 O O   . HOH F 5 .   ? 33.809  -2.501  -28.652 1.00 42.51 ? 739 HOH A O   1 
HETATM 2587 O O   . HOH F 5 .   ? 1.578   -0.100  -23.562 1.00 34.37 ? 740 HOH A O   1 
HETATM 2588 O O   . HOH F 5 .   ? 5.496   19.793  -21.319 1.00 31.99 ? 741 HOH A O   1 
HETATM 2589 O O   . HOH F 5 .   ? 29.669  -6.819  -27.106 1.00 24.73 ? 742 HOH A O   1 
HETATM 2590 O O   . HOH F 5 .   ? 10.550  8.226   -31.105 1.00 29.04 ? 743 HOH A O   1 
HETATM 2591 O O   . HOH F 5 .   ? 10.946  22.167  -15.802 1.00 32.65 ? 744 HOH A O   1 
HETATM 2592 O O   . HOH F 5 .   ? 37.656  0.882   -13.291 1.00 23.56 ? 745 HOH A O   1 
# 
