data_9IZP
# 
_entry.id   9IZP 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9IZP         pdb_00009izp 10.2210/pdb9izp/pdb 
WWPDB D_1300050056 ?            ?                   
EMDB  EMD-61038    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-06-11 ? 
2 'EM metadata'     1 0 2025-06-11 ? 
3 FSC               1 0 2025-06-11 ? 
4 'Half map'        1 0 2025-06-11 1 
5 'Half map'        1 0 2025-06-11 2 
6 Image             1 0 2025-06-11 ? 
7 Mask              1 0 2025-06-11 1 
8 'Primary map'     1 0 2025-06-11 ? 
# 
loop_
_pdbx_audit_revision_details.ordinal 
_pdbx_audit_revision_details.revision_ordinal 
_pdbx_audit_revision_details.data_content_type 
_pdbx_audit_revision_details.provider 
_pdbx_audit_revision_details.type 
_pdbx_audit_revision_details.description 
_pdbx_audit_revision_details.details 
1 1 'Structure model' repository 'Initial release' ? ? 
2 2 'EM metadata'     repository 'Initial release' ? ? 
3 3 FSC               repository 'Initial release' ? ? 
4 4 'Half map'        repository 'Initial release' ? ? 
5 5 'Half map'        repository 'Initial release' ? ? 
6 6 Image             repository 'Initial release' ? ? 
7 7 Mask              repository 'Initial release' ? ? 
8 8 'Primary map'     repository 'Initial release' ? ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9IZP 
_pdbx_database_status.recvd_initial_deposition_date   2024-08-01 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Cryo-EM structure of CasLambda2-crRNA-target DNA ternary complex in the incompetent state' 
_pdbx_database_related.db_id          EMD-61038 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              nureki@bs.s.u-tokyo.ac.jp 
_pdbx_contact_author.name_first         Osamu 
_pdbx_contact_author.name_last          Nureki 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-1813-7008 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Omura, S.N.' 1 0000-0003-2436-0847 
'Hirano, H.'  2 0009-0006-3176-6174 
'Itoh, Y.'    3 0000-0001-7802-5572 
'Nureki, O.'  4 0000-0003-1813-7008 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Structural basis for the target DNA cleavage and guide RNA processing by the CRISPR-CasLambda2' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Omura, S.N.' 1 0000-0003-2436-0847 
primary 'Hirano, H.'  2 0009-0006-3176-6174 
primary 'Itoh, Y.'    3 0000-0001-7802-5572 
primary 'Nureki, O.'  4 0000-0003-1813-7008 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Cas Lambda2'   88746.492 1 ? ? ? ? 
2 polymer     man 'RNA (58-MER)'  18692.006 1 ? ? ? ? 
3 polymer     man 'DNA (40-MER)'  12591.749 1 ? ? ? ? 
4 polymer     man 'DNA (40-MER)'  12418.669 1 ? ? ? ? 
5 non-polymer syn 'MAGNESIUM ION' 24.305    3 ? ? ? ? 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)'        no no  
;MGHHHHHHGGMKKSIKFKVKGNCPITKDVINEYKEYYNKCSDWIKNNLTSITIGEMAKFLQETLGKDVAYISMGLSDEWK
DKPLYHLFTKKYHTNNADNLLYYYIKEKNLDGYKGNTLNIGNTFFRQFGYFKLVVSNYRTKIRTLNCEIKRKKIDADSTS
EDIEMQTMYEIIKHNLNKKTDWDEFISYIENVENPNIDNINRYKLLRKCFCENENMIKNKLELLSIEQLKNFGGCIMKQH
INSMTLIIQHFKIEEKENSLGFILNLPLNKKQYQIELWGNRQVNKGTKERDAFLNTYGENIVFIINNDELYVVFSYEYEL
EKEEANFVKTVGLDVNFKHAFFVTSEKDNCHLDGYINLYKYLLEHDEFTNLLTNDEKKDYEELSKVVTFCPFENQLLFAR
YNKMSKFCKKEQVLSKLLYALQKQLKDENRTKEYIYVSCVNKLRAKYVSYFILKEKYYEKQKEYDIEMGFVDDSTESKES
MDKRRTEFPFRNTPVANELLSKLNNVQQDINGCLKNIINYIYKIFEQNGYKIVALENLENSNFEKKQVLPTIKSLLKYHK
LENQNVNDIKASDKVKEYIENGYYELITNENNEIVDAKYTEKGAMKVKNANFFNLMMKSLHFASVKDEFVLLSNNGKTQI
ALVPSEFTSQMDSTDHCLYMKKNDKGKLVKADKKEVRTKQEKHINGLNADFNAANNIKYIVENEVWREIFCTRPKKAEYN
VPSLDTTKKGPSAILHMLKKIEAIKILETEK
;
;MGHHHHHHGGMKKSIKFKVKGNCPITKDVINEYKEYYNKCSDWIKNNLTSITIGEMAKFLQETLGKDVAYISMGLSDEWK
DKPLYHLFTKKYHTNNADNLLYYYIKEKNLDGYKGNTLNIGNTFFRQFGYFKLVVSNYRTKIRTLNCEIKRKKIDADSTS
EDIEMQTMYEIIKHNLNKKTDWDEFISYIENVENPNIDNINRYKLLRKCFCENENMIKNKLELLSIEQLKNFGGCIMKQH
INSMTLIIQHFKIEEKENSLGFILNLPLNKKQYQIELWGNRQVNKGTKERDAFLNTYGENIVFIINNDELYVVFSYEYEL
EKEEANFVKTVGLDVNFKHAFFVTSEKDNCHLDGYINLYKYLLEHDEFTNLLTNDEKKDYEELSKVVTFCPFENQLLFAR
YNKMSKFCKKEQVLSKLLYALQKQLKDENRTKEYIYVSCVNKLRAKYVSYFILKEKYYEKQKEYDIEMGFVDDSTESKES
MDKRRTEFPFRNTPVANELLSKLNNVQQDINGCLKNIINYIYKIFEQNGYKIVALENLENSNFEKKQVLPTIKSLLKYHK
LENQNVNDIKASDKVKEYIENGYYELITNENNEIVDAKYTEKGAMKVKNANFFNLMMKSLHFASVKDEFVLLSNNGKTQI
ALVPSEFTSQMDSTDHCLYMKKNDKGKLVKADKKEVRTKQEKHINGLNADFNAANNIKYIVENEVWREIFCTRPKKAEYN
VPSLDTTKKGPSAILHMLKKIEAIKILETEK
;
A ? 
2 polyribonucleotide      no no  GGCUUGUUGUAUAUAUUCUUUUAUAGGUAUUAAACAACGGAGAUGAGGUGCGCGUGGC 
GGCUUGUUGUAUAUAUUCUUUUAUAGGUAUUAAACAACGGAGAUGAGGUGCGCGUGGC B ? 
3 polydeoxyribonucleotide no yes 
;(DT)(DG)(DT)(DC)(DT)(DA)(DT)(DT)(DT)(DA)(DG)(DG)(DA)(DG)(DA)(DT)(DG)(DA)(DG)(DG)
(DT)(DG)(DC)(DG)(DC)(DG)(DT)(DG)(GS)(SC)(AS)(SC)(SC)(AS)(PST)(SC)(AS)(PST)(AS)
(PST)
;
TGTCTATTTAGGAGATGAGGTGCGCGTGGCACCATCATAT C ? 
4 polydeoxyribonucleotide no yes 
;(AS)(PST)(AS)(PST)(GS)(AS)(PST)(GS)(GS)(PST)(GS)(SC)(DC)(DA)(DC)(DG)(DC)(DG)(DC)
(DA)(DC)(DC)(DT)(DC)(DA)(DT)(DC)(DT)(DC)(DC)(DT)(DA)(DA)(DA)(DT)(DA)(DG)(DA)(DC)
(DA)
;
ATATGATGGTGCCACGCGCACCTCATCTCCTAAATAGACA D ? 
# 
_pdbx_entity_nonpoly.entity_id   5 
_pdbx_entity_nonpoly.name        'MAGNESIUM ION' 
_pdbx_entity_nonpoly.comp_id     MG 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLY n 
1 3   HIS n 
1 4   HIS n 
1 5   HIS n 
1 6   HIS n 
1 7   HIS n 
1 8   HIS n 
1 9   GLY n 
1 10  GLY n 
1 11  MET n 
1 12  LYS n 
1 13  LYS n 
1 14  SER n 
1 15  ILE n 
1 16  LYS n 
1 17  PHE n 
1 18  LYS n 
1 19  VAL n 
1 20  LYS n 
1 21  GLY n 
1 22  ASN n 
1 23  CYS n 
1 24  PRO n 
1 25  ILE n 
1 26  THR n 
1 27  LYS n 
1 28  ASP n 
1 29  VAL n 
1 30  ILE n 
1 31  ASN n 
1 32  GLU n 
1 33  TYR n 
1 34  LYS n 
1 35  GLU n 
1 36  TYR n 
1 37  TYR n 
1 38  ASN n 
1 39  LYS n 
1 40  CYS n 
1 41  SER n 
1 42  ASP n 
1 43  TRP n 
1 44  ILE n 
1 45  LYS n 
1 46  ASN n 
1 47  ASN n 
1 48  LEU n 
1 49  THR n 
1 50  SER n 
1 51  ILE n 
1 52  THR n 
1 53  ILE n 
1 54  GLY n 
1 55  GLU n 
1 56  MET n 
1 57  ALA n 
1 58  LYS n 
1 59  PHE n 
1 60  LEU n 
1 61  GLN n 
1 62  GLU n 
1 63  THR n 
1 64  LEU n 
1 65  GLY n 
1 66  LYS n 
1 67  ASP n 
1 68  VAL n 
1 69  ALA n 
1 70  TYR n 
1 71  ILE n 
1 72  SER n 
1 73  MET n 
1 74  GLY n 
1 75  LEU n 
1 76  SER n 
1 77  ASP n 
1 78  GLU n 
1 79  TRP n 
1 80  LYS n 
1 81  ASP n 
1 82  LYS n 
1 83  PRO n 
1 84  LEU n 
1 85  TYR n 
1 86  HIS n 
1 87  LEU n 
1 88  PHE n 
1 89  THR n 
1 90  LYS n 
1 91  LYS n 
1 92  TYR n 
1 93  HIS n 
1 94  THR n 
1 95  ASN n 
1 96  ASN n 
1 97  ALA n 
1 98  ASP n 
1 99  ASN n 
1 100 LEU n 
1 101 LEU n 
1 102 TYR n 
1 103 TYR n 
1 104 TYR n 
1 105 ILE n 
1 106 LYS n 
1 107 GLU n 
1 108 LYS n 
1 109 ASN n 
1 110 LEU n 
1 111 ASP n 
1 112 GLY n 
1 113 TYR n 
1 114 LYS n 
1 115 GLY n 
1 116 ASN n 
1 117 THR n 
1 118 LEU n 
1 119 ASN n 
1 120 ILE n 
1 121 GLY n 
1 122 ASN n 
1 123 THR n 
1 124 PHE n 
1 125 PHE n 
1 126 ARG n 
1 127 GLN n 
1 128 PHE n 
1 129 GLY n 
1 130 TYR n 
1 131 PHE n 
1 132 LYS n 
1 133 LEU n 
1 134 VAL n 
1 135 VAL n 
1 136 SER n 
1 137 ASN n 
1 138 TYR n 
1 139 ARG n 
1 140 THR n 
1 141 LYS n 
1 142 ILE n 
1 143 ARG n 
1 144 THR n 
1 145 LEU n 
1 146 ASN n 
1 147 CYS n 
1 148 GLU n 
1 149 ILE n 
1 150 LYS n 
1 151 ARG n 
1 152 LYS n 
1 153 LYS n 
1 154 ILE n 
1 155 ASP n 
1 156 ALA n 
1 157 ASP n 
1 158 SER n 
1 159 THR n 
1 160 SER n 
1 161 GLU n 
1 162 ASP n 
1 163 ILE n 
1 164 GLU n 
1 165 MET n 
1 166 GLN n 
1 167 THR n 
1 168 MET n 
1 169 TYR n 
1 170 GLU n 
1 171 ILE n 
1 172 ILE n 
1 173 LYS n 
1 174 HIS n 
1 175 ASN n 
1 176 LEU n 
1 177 ASN n 
1 178 LYS n 
1 179 LYS n 
1 180 THR n 
1 181 ASP n 
1 182 TRP n 
1 183 ASP n 
1 184 GLU n 
1 185 PHE n 
1 186 ILE n 
1 187 SER n 
1 188 TYR n 
1 189 ILE n 
1 190 GLU n 
1 191 ASN n 
1 192 VAL n 
1 193 GLU n 
1 194 ASN n 
1 195 PRO n 
1 196 ASN n 
1 197 ILE n 
1 198 ASP n 
1 199 ASN n 
1 200 ILE n 
1 201 ASN n 
1 202 ARG n 
1 203 TYR n 
1 204 LYS n 
1 205 LEU n 
1 206 LEU n 
1 207 ARG n 
1 208 LYS n 
1 209 CYS n 
1 210 PHE n 
1 211 CYS n 
1 212 GLU n 
1 213 ASN n 
1 214 GLU n 
1 215 ASN n 
1 216 MET n 
1 217 ILE n 
1 218 LYS n 
1 219 ASN n 
1 220 LYS n 
1 221 LEU n 
1 222 GLU n 
1 223 LEU n 
1 224 LEU n 
1 225 SER n 
1 226 ILE n 
1 227 GLU n 
1 228 GLN n 
1 229 LEU n 
1 230 LYS n 
1 231 ASN n 
1 232 PHE n 
1 233 GLY n 
1 234 GLY n 
1 235 CYS n 
1 236 ILE n 
1 237 MET n 
1 238 LYS n 
1 239 GLN n 
1 240 HIS n 
1 241 ILE n 
1 242 ASN n 
1 243 SER n 
1 244 MET n 
1 245 THR n 
1 246 LEU n 
1 247 ILE n 
1 248 ILE n 
1 249 GLN n 
1 250 HIS n 
1 251 PHE n 
1 252 LYS n 
1 253 ILE n 
1 254 GLU n 
1 255 GLU n 
1 256 LYS n 
1 257 GLU n 
1 258 ASN n 
1 259 SER n 
1 260 LEU n 
1 261 GLY n 
1 262 PHE n 
1 263 ILE n 
1 264 LEU n 
1 265 ASN n 
1 266 LEU n 
1 267 PRO n 
1 268 LEU n 
1 269 ASN n 
1 270 LYS n 
1 271 LYS n 
1 272 GLN n 
1 273 TYR n 
1 274 GLN n 
1 275 ILE n 
1 276 GLU n 
1 277 LEU n 
1 278 TRP n 
1 279 GLY n 
1 280 ASN n 
1 281 ARG n 
1 282 GLN n 
1 283 VAL n 
1 284 ASN n 
1 285 LYS n 
1 286 GLY n 
1 287 THR n 
1 288 LYS n 
1 289 GLU n 
1 290 ARG n 
1 291 ASP n 
1 292 ALA n 
1 293 PHE n 
1 294 LEU n 
1 295 ASN n 
1 296 THR n 
1 297 TYR n 
1 298 GLY n 
1 299 GLU n 
1 300 ASN n 
1 301 ILE n 
1 302 VAL n 
1 303 PHE n 
1 304 ILE n 
1 305 ILE n 
1 306 ASN n 
1 307 ASN n 
1 308 ASP n 
1 309 GLU n 
1 310 LEU n 
1 311 TYR n 
1 312 VAL n 
1 313 VAL n 
1 314 PHE n 
1 315 SER n 
1 316 TYR n 
1 317 GLU n 
1 318 TYR n 
1 319 GLU n 
1 320 LEU n 
1 321 GLU n 
1 322 LYS n 
1 323 GLU n 
1 324 GLU n 
1 325 ALA n 
1 326 ASN n 
1 327 PHE n 
1 328 VAL n 
1 329 LYS n 
1 330 THR n 
1 331 VAL n 
1 332 GLY n 
1 333 LEU n 
1 334 ASP n 
1 335 VAL n 
1 336 ASN n 
1 337 PHE n 
1 338 LYS n 
1 339 HIS n 
1 340 ALA n 
1 341 PHE n 
1 342 PHE n 
1 343 VAL n 
1 344 THR n 
1 345 SER n 
1 346 GLU n 
1 347 LYS n 
1 348 ASP n 
1 349 ASN n 
1 350 CYS n 
1 351 HIS n 
1 352 LEU n 
1 353 ASP n 
1 354 GLY n 
1 355 TYR n 
1 356 ILE n 
1 357 ASN n 
1 358 LEU n 
1 359 TYR n 
1 360 LYS n 
1 361 TYR n 
1 362 LEU n 
1 363 LEU n 
1 364 GLU n 
1 365 HIS n 
1 366 ASP n 
1 367 GLU n 
1 368 PHE n 
1 369 THR n 
1 370 ASN n 
1 371 LEU n 
1 372 LEU n 
1 373 THR n 
1 374 ASN n 
1 375 ASP n 
1 376 GLU n 
1 377 LYS n 
1 378 LYS n 
1 379 ASP n 
1 380 TYR n 
1 381 GLU n 
1 382 GLU n 
1 383 LEU n 
1 384 SER n 
1 385 LYS n 
1 386 VAL n 
1 387 VAL n 
1 388 THR n 
1 389 PHE n 
1 390 CYS n 
1 391 PRO n 
1 392 PHE n 
1 393 GLU n 
1 394 ASN n 
1 395 GLN n 
1 396 LEU n 
1 397 LEU n 
1 398 PHE n 
1 399 ALA n 
1 400 ARG n 
1 401 TYR n 
1 402 ASN n 
1 403 LYS n 
1 404 MET n 
1 405 SER n 
1 406 LYS n 
1 407 PHE n 
1 408 CYS n 
1 409 LYS n 
1 410 LYS n 
1 411 GLU n 
1 412 GLN n 
1 413 VAL n 
1 414 LEU n 
1 415 SER n 
1 416 LYS n 
1 417 LEU n 
1 418 LEU n 
1 419 TYR n 
1 420 ALA n 
1 421 LEU n 
1 422 GLN n 
1 423 LYS n 
1 424 GLN n 
1 425 LEU n 
1 426 LYS n 
1 427 ASP n 
1 428 GLU n 
1 429 ASN n 
1 430 ARG n 
1 431 THR n 
1 432 LYS n 
1 433 GLU n 
1 434 TYR n 
1 435 ILE n 
1 436 TYR n 
1 437 VAL n 
1 438 SER n 
1 439 CYS n 
1 440 VAL n 
1 441 ASN n 
1 442 LYS n 
1 443 LEU n 
1 444 ARG n 
1 445 ALA n 
1 446 LYS n 
1 447 TYR n 
1 448 VAL n 
1 449 SER n 
1 450 TYR n 
1 451 PHE n 
1 452 ILE n 
1 453 LEU n 
1 454 LYS n 
1 455 GLU n 
1 456 LYS n 
1 457 TYR n 
1 458 TYR n 
1 459 GLU n 
1 460 LYS n 
1 461 GLN n 
1 462 LYS n 
1 463 GLU n 
1 464 TYR n 
1 465 ASP n 
1 466 ILE n 
1 467 GLU n 
1 468 MET n 
1 469 GLY n 
1 470 PHE n 
1 471 VAL n 
1 472 ASP n 
1 473 ASP n 
1 474 SER n 
1 475 THR n 
1 476 GLU n 
1 477 SER n 
1 478 LYS n 
1 479 GLU n 
1 480 SER n 
1 481 MET n 
1 482 ASP n 
1 483 LYS n 
1 484 ARG n 
1 485 ARG n 
1 486 THR n 
1 487 GLU n 
1 488 PHE n 
1 489 PRO n 
1 490 PHE n 
1 491 ARG n 
1 492 ASN n 
1 493 THR n 
1 494 PRO n 
1 495 VAL n 
1 496 ALA n 
1 497 ASN n 
1 498 GLU n 
1 499 LEU n 
1 500 LEU n 
1 501 SER n 
1 502 LYS n 
1 503 LEU n 
1 504 ASN n 
1 505 ASN n 
1 506 VAL n 
1 507 GLN n 
1 508 GLN n 
1 509 ASP n 
1 510 ILE n 
1 511 ASN n 
1 512 GLY n 
1 513 CYS n 
1 514 LEU n 
1 515 LYS n 
1 516 ASN n 
1 517 ILE n 
1 518 ILE n 
1 519 ASN n 
1 520 TYR n 
1 521 ILE n 
1 522 TYR n 
1 523 LYS n 
1 524 ILE n 
1 525 PHE n 
1 526 GLU n 
1 527 GLN n 
1 528 ASN n 
1 529 GLY n 
1 530 TYR n 
1 531 LYS n 
1 532 ILE n 
1 533 VAL n 
1 534 ALA n 
1 535 LEU n 
1 536 GLU n 
1 537 ASN n 
1 538 LEU n 
1 539 GLU n 
1 540 ASN n 
1 541 SER n 
1 542 ASN n 
1 543 PHE n 
1 544 GLU n 
1 545 LYS n 
1 546 LYS n 
1 547 GLN n 
1 548 VAL n 
1 549 LEU n 
1 550 PRO n 
1 551 THR n 
1 552 ILE n 
1 553 LYS n 
1 554 SER n 
1 555 LEU n 
1 556 LEU n 
1 557 LYS n 
1 558 TYR n 
1 559 HIS n 
1 560 LYS n 
1 561 LEU n 
1 562 GLU n 
1 563 ASN n 
1 564 GLN n 
1 565 ASN n 
1 566 VAL n 
1 567 ASN n 
1 568 ASP n 
1 569 ILE n 
1 570 LYS n 
1 571 ALA n 
1 572 SER n 
1 573 ASP n 
1 574 LYS n 
1 575 VAL n 
1 576 LYS n 
1 577 GLU n 
1 578 TYR n 
1 579 ILE n 
1 580 GLU n 
1 581 ASN n 
1 582 GLY n 
1 583 TYR n 
1 584 TYR n 
1 585 GLU n 
1 586 LEU n 
1 587 ILE n 
1 588 THR n 
1 589 ASN n 
1 590 GLU n 
1 591 ASN n 
1 592 ASN n 
1 593 GLU n 
1 594 ILE n 
1 595 VAL n 
1 596 ASP n 
1 597 ALA n 
1 598 LYS n 
1 599 TYR n 
1 600 THR n 
1 601 GLU n 
1 602 LYS n 
1 603 GLY n 
1 604 ALA n 
1 605 MET n 
1 606 LYS n 
1 607 VAL n 
1 608 LYS n 
1 609 ASN n 
1 610 ALA n 
1 611 ASN n 
1 612 PHE n 
1 613 PHE n 
1 614 ASN n 
1 615 LEU n 
1 616 MET n 
1 617 MET n 
1 618 LYS n 
1 619 SER n 
1 620 LEU n 
1 621 HIS n 
1 622 PHE n 
1 623 ALA n 
1 624 SER n 
1 625 VAL n 
1 626 LYS n 
1 627 ASP n 
1 628 GLU n 
1 629 PHE n 
1 630 VAL n 
1 631 LEU n 
1 632 LEU n 
1 633 SER n 
1 634 ASN n 
1 635 ASN n 
1 636 GLY n 
1 637 LYS n 
1 638 THR n 
1 639 GLN n 
1 640 ILE n 
1 641 ALA n 
1 642 LEU n 
1 643 VAL n 
1 644 PRO n 
1 645 SER n 
1 646 GLU n 
1 647 PHE n 
1 648 THR n 
1 649 SER n 
1 650 GLN n 
1 651 MET n 
1 652 ASP n 
1 653 SER n 
1 654 THR n 
1 655 ASP n 
1 656 HIS n 
1 657 CYS n 
1 658 LEU n 
1 659 TYR n 
1 660 MET n 
1 661 LYS n 
1 662 LYS n 
1 663 ASN n 
1 664 ASP n 
1 665 LYS n 
1 666 GLY n 
1 667 LYS n 
1 668 LEU n 
1 669 VAL n 
1 670 LYS n 
1 671 ALA n 
1 672 ASP n 
1 673 LYS n 
1 674 LYS n 
1 675 GLU n 
1 676 VAL n 
1 677 ARG n 
1 678 THR n 
1 679 LYS n 
1 680 GLN n 
1 681 GLU n 
1 682 LYS n 
1 683 HIS n 
1 684 ILE n 
1 685 ASN n 
1 686 GLY n 
1 687 LEU n 
1 688 ASN n 
1 689 ALA n 
1 690 ASP n 
1 691 PHE n 
1 692 ASN n 
1 693 ALA n 
1 694 ALA n 
1 695 ASN n 
1 696 ASN n 
1 697 ILE n 
1 698 LYS n 
1 699 TYR n 
1 700 ILE n 
1 701 VAL n 
1 702 GLU n 
1 703 ASN n 
1 704 GLU n 
1 705 VAL n 
1 706 TRP n 
1 707 ARG n 
1 708 GLU n 
1 709 ILE n 
1 710 PHE n 
1 711 CYS n 
1 712 THR n 
1 713 ARG n 
1 714 PRO n 
1 715 LYS n 
1 716 LYS n 
1 717 ALA n 
1 718 GLU n 
1 719 TYR n 
1 720 ASN n 
1 721 VAL n 
1 722 PRO n 
1 723 SER n 
1 724 LEU n 
1 725 ASP n 
1 726 THR n 
1 727 THR n 
1 728 LYS n 
1 729 LYS n 
1 730 GLY n 
1 731 PRO n 
1 732 SER n 
1 733 ALA n 
1 734 ILE n 
1 735 LEU n 
1 736 HIS n 
1 737 MET n 
1 738 LEU n 
1 739 LYS n 
1 740 LYS n 
1 741 ILE n 
1 742 GLU n 
1 743 ALA n 
1 744 ILE n 
1 745 LYS n 
1 746 ILE n 
1 747 LEU n 
1 748 GLU n 
1 749 THR n 
1 750 GLU n 
1 751 LYS n 
2 1   G   n 
2 2   G   n 
2 3   C   n 
2 4   U   n 
2 5   U   n 
2 6   G   n 
2 7   U   n 
2 8   U   n 
2 9   G   n 
2 10  U   n 
2 11  A   n 
2 12  U   n 
2 13  A   n 
2 14  U   n 
2 15  A   n 
2 16  U   n 
2 17  U   n 
2 18  C   n 
2 19  U   n 
2 20  U   n 
2 21  U   n 
2 22  U   n 
2 23  A   n 
2 24  U   n 
2 25  A   n 
2 26  G   n 
2 27  G   n 
2 28  U   n 
2 29  A   n 
2 30  U   n 
2 31  U   n 
2 32  A   n 
2 33  A   n 
2 34  A   n 
2 35  C   n 
2 36  A   n 
2 37  A   n 
2 38  C   n 
2 39  G   n 
2 40  G   n 
2 41  A   n 
2 42  G   n 
2 43  A   n 
2 44  U   n 
2 45  G   n 
2 46  A   n 
2 47  G   n 
2 48  G   n 
2 49  U   n 
2 50  G   n 
2 51  C   n 
2 52  G   n 
2 53  C   n 
2 54  G   n 
2 55  U   n 
2 56  G   n 
2 57  G   n 
2 58  C   n 
3 1   DT  n 
3 2   DG  n 
3 3   DT  n 
3 4   DC  n 
3 5   DT  n 
3 6   DA  n 
3 7   DT  n 
3 8   DT  n 
3 9   DT  n 
3 10  DA  n 
3 11  DG  n 
3 12  DG  n 
3 13  DA  n 
3 14  DG  n 
3 15  DA  n 
3 16  DT  n 
3 17  DG  n 
3 18  DA  n 
3 19  DG  n 
3 20  DG  n 
3 21  DT  n 
3 22  DG  n 
3 23  DC  n 
3 24  DG  n 
3 25  DC  n 
3 26  DG  n 
3 27  DT  n 
3 28  DG  n 
3 29  GS  n 
3 30  SC  n 
3 31  AS  n 
3 32  SC  n 
3 33  SC  n 
3 34  AS  n 
3 35  PST n 
3 36  SC  n 
3 37  AS  n 
3 38  PST n 
3 39  AS  n 
3 40  PST n 
4 1   AS  n 
4 2   PST n 
4 3   AS  n 
4 4   PST n 
4 5   GS  n 
4 6   AS  n 
4 7   PST n 
4 8   GS  n 
4 9   GS  n 
4 10  PST n 
4 11  GS  n 
4 12  SC  n 
4 13  DC  n 
4 14  DA  n 
4 15  DC  n 
4 16  DG  n 
4 17  DC  n 
4 18  DG  n 
4 19  DC  n 
4 20  DA  n 
4 21  DC  n 
4 22  DC  n 
4 23  DT  n 
4 24  DC  n 
4 25  DA  n 
4 26  DT  n 
4 27  DC  n 
4 28  DT  n 
4 29  DC  n 
4 30  DC  n 
4 31  DT  n 
4 32  DA  n 
4 33  DA  n 
4 34  DA  n 
4 35  DT  n 
4 36  DA  n 
4 37  DG  n 
4 38  DA  n 
4 39  DC  n 
4 40  DA  n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 751 ? ? ? ? ? ? ? ? ? unidentified 32644 ? ? ? ? ? ? ? ? 'Escherichia coli' 562 ? ? ? ? ? ? ? ? 
? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 58  ? ? ? ? ? ? ? ? ? unidentified 32644 ? ? ? ? ? ? ? ? 'Escherichia coli' 562 ? ? ? ? ? ? ? ? 
? ? ? ? ? ? ? ? ? ? ? ? ? 
3 1 sample 'Biological sequence' 1 40  ? ? ? ? ? ? ? ? ? unidentified 32644 ? ? ? ? ? ? ? ? 'Escherichia coli' 562 ? ? ? ? ? ? ? ? 
? ? ? ? ? ? ? ? ? ? ? ? ? 
4 1 sample 'Biological sequence' 1 40  ? ? ? ? ? ? ? ? ? unidentified 32644 ? ? ? ? ? ? ? ? 'Escherichia coli' 562 ? ? ? ? ? ? ? ? 
? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A   'RNA linking'       y "ADENOSINE-5'-MONOPHOSPHATE"               ? 'C10 H14 N5 O7 P'   347.221 
ALA 'L-peptide linking' y ALANINE                                    ? 'C3 H7 N O2'        89.093  
ARG 'L-peptide linking' y ARGININE                                   ? 'C6 H15 N4 O2 1'    175.209 
AS  'DNA linking'       n 
;2-DEOXY-ADENOSINE -5'-THIO-MONOPHOSPHATE
;
? 'C10 H14 N5 O5 P S' 347.287 
ASN 'L-peptide linking' y ASPARAGINE                                 ? 'C4 H8 N2 O3'       132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                            ? 'C4 H7 N O4'        133.103 
C   'RNA linking'       y "CYTIDINE-5'-MONOPHOSPHATE"                ? 'C9 H14 N3 O8 P'    323.197 
CYS 'L-peptide linking' y CYSTEINE                                   ? 'C3 H7 N O2 S'      121.158 
DA  'DNA linking'       y "2'-DEOXYADENOSINE-5'-MONOPHOSPHATE"       ? 'C10 H14 N5 O6 P'   331.222 
DC  'DNA linking'       y "2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE"        ? 'C9 H14 N3 O7 P'    307.197 
DG  'DNA linking'       y "2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE"       ? 'C10 H14 N5 O7 P'   347.221 
DT  'DNA linking'       y "THYMIDINE-5'-MONOPHOSPHATE"               ? 'C10 H15 N2 O8 P'   322.208 
G   'RNA linking'       y "GUANOSINE-5'-MONOPHOSPHATE"               ? 'C10 H14 N5 O8 P'   363.221 
GLN 'L-peptide linking' y GLUTAMINE                                  ? 'C5 H10 N2 O3'      146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                            ? 'C5 H9 N O4'        147.129 
GLY 'peptide linking'   y GLYCINE                                    ? 'C2 H5 N O2'        75.067  
GS  'DNA linking'       n "GUANOSINE-5'-THIO-MONOPHOSPHATE"          ? 'C10 H14 N5 O6 P S' 363.287 
HIS 'L-peptide linking' y HISTIDINE                                  ? 'C6 H10 N3 O2 1'    156.162 
ILE 'L-peptide linking' y ISOLEUCINE                                 ? 'C6 H13 N O2'       131.173 
LEU 'L-peptide linking' y LEUCINE                                    ? 'C6 H13 N O2'       131.173 
LYS 'L-peptide linking' y LYSINE                                     ? 'C6 H15 N2 O2 1'    147.195 
MET 'L-peptide linking' y METHIONINE                                 ? 'C5 H11 N O2 S'     149.211 
MG  non-polymer         . 'MAGNESIUM ION'                            ? 'Mg 2'              24.305  
PHE 'L-peptide linking' y PHENYLALANINE                              ? 'C9 H11 N O2'       165.189 
PRO 'L-peptide linking' y PROLINE                                    ? 'C5 H9 N O2'        115.130 
PST 'DNA linking'       n "THYMIDINE-5'-THIOPHOSPHATE"               ? 'C10 H15 N2 O7 P S' 338.274 
SC  'DNA linking'       n "2-DEOXY-CYTIDINE-5'-THIOPHOSPHORATE"      ? 'C9 H14 N3 O6 P S'  323.263 
SER 'L-peptide linking' y SERINE                                     ? 'C3 H7 N O3'        105.093 
THR 'L-peptide linking' y THREONINE                                  ? 'C4 H9 N O3'        119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                 ? 'C11 H12 N2 O2'     204.225 
TYR 'L-peptide linking' y TYROSINE                                   ? 'C9 H11 N O3'       181.189 
U   'RNA linking'       y "URIDINE-5'-MONOPHOSPHATE"                 ? 'C9 H13 N2 O9 P'    324.181 
VAL 'L-peptide linking' y VALINE                                     ? 'C5 H11 N O2'       117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -9  ?   ?   ?   A . n 
A 1 2   GLY 2   -8  ?   ?   ?   A . n 
A 1 3   HIS 3   -7  ?   ?   ?   A . n 
A 1 4   HIS 4   -6  ?   ?   ?   A . n 
A 1 5   HIS 5   -5  ?   ?   ?   A . n 
A 1 6   HIS 6   -4  ?   ?   ?   A . n 
A 1 7   HIS 7   -3  ?   ?   ?   A . n 
A 1 8   HIS 8   -2  ?   ?   ?   A . n 
A 1 9   GLY 9   -1  ?   ?   ?   A . n 
A 1 10  GLY 10  0   ?   ?   ?   A . n 
A 1 11  MET 11  1   1   MET MET A . n 
A 1 12  LYS 12  2   2   LYS LYS A . n 
A 1 13  LYS 13  3   3   LYS LYS A . n 
A 1 14  SER 14  4   4   SER SER A . n 
A 1 15  ILE 15  5   5   ILE ILE A . n 
A 1 16  LYS 16  6   6   LYS LYS A . n 
A 1 17  PHE 17  7   7   PHE PHE A . n 
A 1 18  LYS 18  8   8   LYS LYS A . n 
A 1 19  VAL 19  9   9   VAL VAL A . n 
A 1 20  LYS 20  10  10  LYS LYS A . n 
A 1 21  GLY 21  11  11  GLY GLY A . n 
A 1 22  ASN 22  12  12  ASN ASN A . n 
A 1 23  CYS 23  13  13  CYS CYS A . n 
A 1 24  PRO 24  14  14  PRO PRO A . n 
A 1 25  ILE 25  15  15  ILE ILE A . n 
A 1 26  THR 26  16  16  THR THR A . n 
A 1 27  LYS 27  17  17  LYS LYS A . n 
A 1 28  ASP 28  18  18  ASP ASP A . n 
A 1 29  VAL 29  19  19  VAL VAL A . n 
A 1 30  ILE 30  20  20  ILE ILE A . n 
A 1 31  ASN 31  21  21  ASN ASN A . n 
A 1 32  GLU 32  22  22  GLU GLU A . n 
A 1 33  TYR 33  23  23  TYR TYR A . n 
A 1 34  LYS 34  24  24  LYS LYS A . n 
A 1 35  GLU 35  25  25  GLU GLU A . n 
A 1 36  TYR 36  26  26  TYR TYR A . n 
A 1 37  TYR 37  27  27  TYR TYR A . n 
A 1 38  ASN 38  28  28  ASN ASN A . n 
A 1 39  LYS 39  29  29  LYS LYS A . n 
A 1 40  CYS 40  30  30  CYS CYS A . n 
A 1 41  SER 41  31  31  SER SER A . n 
A 1 42  ASP 42  32  32  ASP ASP A . n 
A 1 43  TRP 43  33  33  TRP TRP A . n 
A 1 44  ILE 44  34  34  ILE ILE A . n 
A 1 45  LYS 45  35  35  LYS LYS A . n 
A 1 46  ASN 46  36  36  ASN ASN A . n 
A 1 47  ASN 47  37  37  ASN ASN A . n 
A 1 48  LEU 48  38  38  LEU LEU A . n 
A 1 49  THR 49  39  39  THR THR A . n 
A 1 50  SER 50  40  40  SER SER A . n 
A 1 51  ILE 51  41  41  ILE ILE A . n 
A 1 52  THR 52  42  42  THR THR A . n 
A 1 53  ILE 53  43  43  ILE ILE A . n 
A 1 54  GLY 54  44  44  GLY GLY A . n 
A 1 55  GLU 55  45  45  GLU GLU A . n 
A 1 56  MET 56  46  46  MET MET A . n 
A 1 57  ALA 57  47  47  ALA ALA A . n 
A 1 58  LYS 58  48  48  LYS LYS A . n 
A 1 59  PHE 59  49  49  PHE PHE A . n 
A 1 60  LEU 60  50  50  LEU LEU A . n 
A 1 61  GLN 61  51  51  GLN GLN A . n 
A 1 62  GLU 62  52  52  GLU GLU A . n 
A 1 63  THR 63  53  53  THR THR A . n 
A 1 64  LEU 64  54  54  LEU LEU A . n 
A 1 65  GLY 65  55  55  GLY GLY A . n 
A 1 66  LYS 66  56  56  LYS LYS A . n 
A 1 67  ASP 67  57  57  ASP ASP A . n 
A 1 68  VAL 68  58  58  VAL VAL A . n 
A 1 69  ALA 69  59  59  ALA ALA A . n 
A 1 70  TYR 70  60  60  TYR TYR A . n 
A 1 71  ILE 71  61  61  ILE ILE A . n 
A 1 72  SER 72  62  62  SER SER A . n 
A 1 73  MET 73  63  63  MET MET A . n 
A 1 74  GLY 74  64  64  GLY GLY A . n 
A 1 75  LEU 75  65  65  LEU LEU A . n 
A 1 76  SER 76  66  66  SER SER A . n 
A 1 77  ASP 77  67  67  ASP ASP A . n 
A 1 78  GLU 78  68  68  GLU GLU A . n 
A 1 79  TRP 79  69  69  TRP TRP A . n 
A 1 80  LYS 80  70  70  LYS LYS A . n 
A 1 81  ASP 81  71  71  ASP ASP A . n 
A 1 82  LYS 82  72  72  LYS LYS A . n 
A 1 83  PRO 83  73  73  PRO PRO A . n 
A 1 84  LEU 84  74  74  LEU LEU A . n 
A 1 85  TYR 85  75  75  TYR TYR A . n 
A 1 86  HIS 86  76  76  HIS HIS A . n 
A 1 87  LEU 87  77  77  LEU LEU A . n 
A 1 88  PHE 88  78  78  PHE PHE A . n 
A 1 89  THR 89  79  79  THR THR A . n 
A 1 90  LYS 90  80  80  LYS LYS A . n 
A 1 91  LYS 91  81  81  LYS LYS A . n 
A 1 92  TYR 92  82  82  TYR TYR A . n 
A 1 93  HIS 93  83  83  HIS HIS A . n 
A 1 94  THR 94  84  84  THR THR A . n 
A 1 95  ASN 95  85  85  ASN ASN A . n 
A 1 96  ASN 96  86  86  ASN ASN A . n 
A 1 97  ALA 97  87  87  ALA ALA A . n 
A 1 98  ASP 98  88  88  ASP ASP A . n 
A 1 99  ASN 99  89  89  ASN ASN A . n 
A 1 100 LEU 100 90  90  LEU LEU A . n 
A 1 101 LEU 101 91  91  LEU LEU A . n 
A 1 102 TYR 102 92  92  TYR TYR A . n 
A 1 103 TYR 103 93  93  TYR TYR A . n 
A 1 104 TYR 104 94  94  TYR TYR A . n 
A 1 105 ILE 105 95  95  ILE ILE A . n 
A 1 106 LYS 106 96  96  LYS LYS A . n 
A 1 107 GLU 107 97  97  GLU GLU A . n 
A 1 108 LYS 108 98  98  LYS LYS A . n 
A 1 109 ASN 109 99  99  ASN ASN A . n 
A 1 110 LEU 110 100 100 LEU LEU A . n 
A 1 111 ASP 111 101 101 ASP ASP A . n 
A 1 112 GLY 112 102 102 GLY GLY A . n 
A 1 113 TYR 113 103 103 TYR TYR A . n 
A 1 114 LYS 114 104 104 LYS LYS A . n 
A 1 115 GLY 115 105 105 GLY GLY A . n 
A 1 116 ASN 116 106 106 ASN ASN A . n 
A 1 117 THR 117 107 107 THR THR A . n 
A 1 118 LEU 118 108 108 LEU LEU A . n 
A 1 119 ASN 119 109 109 ASN ASN A . n 
A 1 120 ILE 120 110 110 ILE ILE A . n 
A 1 121 GLY 121 111 111 GLY GLY A . n 
A 1 122 ASN 122 112 112 ASN ASN A . n 
A 1 123 THR 123 113 113 THR THR A . n 
A 1 124 PHE 124 114 114 PHE PHE A . n 
A 1 125 PHE 125 115 115 PHE PHE A . n 
A 1 126 ARG 126 116 116 ARG ARG A . n 
A 1 127 GLN 127 117 117 GLN GLN A . n 
A 1 128 PHE 128 118 118 PHE PHE A . n 
A 1 129 GLY 129 119 119 GLY GLY A . n 
A 1 130 TYR 130 120 120 TYR TYR A . n 
A 1 131 PHE 131 121 121 PHE PHE A . n 
A 1 132 LYS 132 122 122 LYS LYS A . n 
A 1 133 LEU 133 123 123 LEU LEU A . n 
A 1 134 VAL 134 124 124 VAL VAL A . n 
A 1 135 VAL 135 125 125 VAL VAL A . n 
A 1 136 SER 136 126 126 SER SER A . n 
A 1 137 ASN 137 127 127 ASN ASN A . n 
A 1 138 TYR 138 128 128 TYR TYR A . n 
A 1 139 ARG 139 129 129 ARG ARG A . n 
A 1 140 THR 140 130 130 THR THR A . n 
A 1 141 LYS 141 131 131 LYS LYS A . n 
A 1 142 ILE 142 132 132 ILE ILE A . n 
A 1 143 ARG 143 133 133 ARG ARG A . n 
A 1 144 THR 144 134 134 THR THR A . n 
A 1 145 LEU 145 135 135 LEU LEU A . n 
A 1 146 ASN 146 136 136 ASN ASN A . n 
A 1 147 CYS 147 137 137 CYS CYS A . n 
A 1 148 GLU 148 138 138 GLU GLU A . n 
A 1 149 ILE 149 139 139 ILE ILE A . n 
A 1 150 LYS 150 140 140 LYS LYS A . n 
A 1 151 ARG 151 141 141 ARG ARG A . n 
A 1 152 LYS 152 142 142 LYS LYS A . n 
A 1 153 LYS 153 143 143 LYS LYS A . n 
A 1 154 ILE 154 144 144 ILE ILE A . n 
A 1 155 ASP 155 145 145 ASP ASP A . n 
A 1 156 ALA 156 146 146 ALA ALA A . n 
A 1 157 ASP 157 147 147 ASP ASP A . n 
A 1 158 SER 158 148 148 SER SER A . n 
A 1 159 THR 159 149 149 THR THR A . n 
A 1 160 SER 160 150 150 SER SER A . n 
A 1 161 GLU 161 151 151 GLU GLU A . n 
A 1 162 ASP 162 152 152 ASP ASP A . n 
A 1 163 ILE 163 153 153 ILE ILE A . n 
A 1 164 GLU 164 154 154 GLU GLU A . n 
A 1 165 MET 165 155 155 MET MET A . n 
A 1 166 GLN 166 156 156 GLN GLN A . n 
A 1 167 THR 167 157 157 THR THR A . n 
A 1 168 MET 168 158 158 MET MET A . n 
A 1 169 TYR 169 159 159 TYR TYR A . n 
A 1 170 GLU 170 160 160 GLU GLU A . n 
A 1 171 ILE 171 161 161 ILE ILE A . n 
A 1 172 ILE 172 162 162 ILE ILE A . n 
A 1 173 LYS 173 163 163 LYS LYS A . n 
A 1 174 HIS 174 164 164 HIS HIS A . n 
A 1 175 ASN 175 165 165 ASN ASN A . n 
A 1 176 LEU 176 166 166 LEU LEU A . n 
A 1 177 ASN 177 167 167 ASN ASN A . n 
A 1 178 LYS 178 168 168 LYS LYS A . n 
A 1 179 LYS 179 169 169 LYS LYS A . n 
A 1 180 THR 180 170 170 THR THR A . n 
A 1 181 ASP 181 171 171 ASP ASP A . n 
A 1 182 TRP 182 172 172 TRP TRP A . n 
A 1 183 ASP 183 173 173 ASP ASP A . n 
A 1 184 GLU 184 174 174 GLU GLU A . n 
A 1 185 PHE 185 175 175 PHE PHE A . n 
A 1 186 ILE 186 176 176 ILE ILE A . n 
A 1 187 SER 187 177 177 SER SER A . n 
A 1 188 TYR 188 178 178 TYR TYR A . n 
A 1 189 ILE 189 179 179 ILE ILE A . n 
A 1 190 GLU 190 180 180 GLU GLU A . n 
A 1 191 ASN 191 181 181 ASN ASN A . n 
A 1 192 VAL 192 182 182 VAL VAL A . n 
A 1 193 GLU 193 183 183 GLU GLU A . n 
A 1 194 ASN 194 184 184 ASN ASN A . n 
A 1 195 PRO 195 185 185 PRO PRO A . n 
A 1 196 ASN 196 186 186 ASN ASN A . n 
A 1 197 ILE 197 187 187 ILE ILE A . n 
A 1 198 ASP 198 188 188 ASP ASP A . n 
A 1 199 ASN 199 189 189 ASN ASN A . n 
A 1 200 ILE 200 190 190 ILE ILE A . n 
A 1 201 ASN 201 191 191 ASN ASN A . n 
A 1 202 ARG 202 192 192 ARG ARG A . n 
A 1 203 TYR 203 193 193 TYR TYR A . n 
A 1 204 LYS 204 194 194 LYS LYS A . n 
A 1 205 LEU 205 195 195 LEU LEU A . n 
A 1 206 LEU 206 196 196 LEU LEU A . n 
A 1 207 ARG 207 197 197 ARG ARG A . n 
A 1 208 LYS 208 198 198 LYS LYS A . n 
A 1 209 CYS 209 199 199 CYS CYS A . n 
A 1 210 PHE 210 200 200 PHE PHE A . n 
A 1 211 CYS 211 201 201 CYS CYS A . n 
A 1 212 GLU 212 202 202 GLU GLU A . n 
A 1 213 ASN 213 203 203 ASN ASN A . n 
A 1 214 GLU 214 204 204 GLU GLU A . n 
A 1 215 ASN 215 205 205 ASN ASN A . n 
A 1 216 MET 216 206 206 MET MET A . n 
A 1 217 ILE 217 207 207 ILE ILE A . n 
A 1 218 LYS 218 208 208 LYS LYS A . n 
A 1 219 ASN 219 209 209 ASN ASN A . n 
A 1 220 LYS 220 210 210 LYS LYS A . n 
A 1 221 LEU 221 211 211 LEU LEU A . n 
A 1 222 GLU 222 212 212 GLU GLU A . n 
A 1 223 LEU 223 213 213 LEU LEU A . n 
A 1 224 LEU 224 214 214 LEU LEU A . n 
A 1 225 SER 225 215 215 SER SER A . n 
A 1 226 ILE 226 216 216 ILE ILE A . n 
A 1 227 GLU 227 217 217 GLU GLU A . n 
A 1 228 GLN 228 218 218 GLN GLN A . n 
A 1 229 LEU 229 219 219 LEU LEU A . n 
A 1 230 LYS 230 220 220 LYS LYS A . n 
A 1 231 ASN 231 221 221 ASN ASN A . n 
A 1 232 PHE 232 222 222 PHE PHE A . n 
A 1 233 GLY 233 223 223 GLY GLY A . n 
A 1 234 GLY 234 224 224 GLY GLY A . n 
A 1 235 CYS 235 225 225 CYS CYS A . n 
A 1 236 ILE 236 226 226 ILE ILE A . n 
A 1 237 MET 237 227 227 MET MET A . n 
A 1 238 LYS 238 228 228 LYS LYS A . n 
A 1 239 GLN 239 229 229 GLN GLN A . n 
A 1 240 HIS 240 230 230 HIS HIS A . n 
A 1 241 ILE 241 231 231 ILE ILE A . n 
A 1 242 ASN 242 232 232 ASN ASN A . n 
A 1 243 SER 243 233 233 SER SER A . n 
A 1 244 MET 244 234 234 MET MET A . n 
A 1 245 THR 245 235 235 THR THR A . n 
A 1 246 LEU 246 236 236 LEU LEU A . n 
A 1 247 ILE 247 237 237 ILE ILE A . n 
A 1 248 ILE 248 238 238 ILE ILE A . n 
A 1 249 GLN 249 239 239 GLN GLN A . n 
A 1 250 HIS 250 240 240 HIS HIS A . n 
A 1 251 PHE 251 241 241 PHE PHE A . n 
A 1 252 LYS 252 242 242 LYS LYS A . n 
A 1 253 ILE 253 243 243 ILE ILE A . n 
A 1 254 GLU 254 244 244 GLU GLU A . n 
A 1 255 GLU 255 245 245 GLU GLU A . n 
A 1 256 LYS 256 246 246 LYS LYS A . n 
A 1 257 GLU 257 247 247 GLU GLU A . n 
A 1 258 ASN 258 248 248 ASN ASN A . n 
A 1 259 SER 259 249 249 SER SER A . n 
A 1 260 LEU 260 250 250 LEU LEU A . n 
A 1 261 GLY 261 251 251 GLY GLY A . n 
A 1 262 PHE 262 252 252 PHE PHE A . n 
A 1 263 ILE 263 253 253 ILE ILE A . n 
A 1 264 LEU 264 254 254 LEU LEU A . n 
A 1 265 ASN 265 255 255 ASN ASN A . n 
A 1 266 LEU 266 256 256 LEU LEU A . n 
A 1 267 PRO 267 257 257 PRO PRO A . n 
A 1 268 LEU 268 258 258 LEU LEU A . n 
A 1 269 ASN 269 259 259 ASN ASN A . n 
A 1 270 LYS 270 260 260 LYS LYS A . n 
A 1 271 LYS 271 261 261 LYS LYS A . n 
A 1 272 GLN 272 262 262 GLN GLN A . n 
A 1 273 TYR 273 263 263 TYR TYR A . n 
A 1 274 GLN 274 264 264 GLN GLN A . n 
A 1 275 ILE 275 265 265 ILE ILE A . n 
A 1 276 GLU 276 266 266 GLU GLU A . n 
A 1 277 LEU 277 267 267 LEU LEU A . n 
A 1 278 TRP 278 268 268 TRP TRP A . n 
A 1 279 GLY 279 269 269 GLY GLY A . n 
A 1 280 ASN 280 270 270 ASN ASN A . n 
A 1 281 ARG 281 271 271 ARG ARG A . n 
A 1 282 GLN 282 272 272 GLN GLN A . n 
A 1 283 VAL 283 273 273 VAL VAL A . n 
A 1 284 ASN 284 274 274 ASN ASN A . n 
A 1 285 LYS 285 275 275 LYS LYS A . n 
A 1 286 GLY 286 276 276 GLY GLY A . n 
A 1 287 THR 287 277 277 THR THR A . n 
A 1 288 LYS 288 278 278 LYS LYS A . n 
A 1 289 GLU 289 279 279 GLU GLU A . n 
A 1 290 ARG 290 280 280 ARG ARG A . n 
A 1 291 ASP 291 281 281 ASP ASP A . n 
A 1 292 ALA 292 282 282 ALA ALA A . n 
A 1 293 PHE 293 283 283 PHE PHE A . n 
A 1 294 LEU 294 284 284 LEU LEU A . n 
A 1 295 ASN 295 285 285 ASN ASN A . n 
A 1 296 THR 296 286 286 THR THR A . n 
A 1 297 TYR 297 287 287 TYR TYR A . n 
A 1 298 GLY 298 288 288 GLY GLY A . n 
A 1 299 GLU 299 289 289 GLU GLU A . n 
A 1 300 ASN 300 290 290 ASN ASN A . n 
A 1 301 ILE 301 291 291 ILE ILE A . n 
A 1 302 VAL 302 292 292 VAL VAL A . n 
A 1 303 PHE 303 293 293 PHE PHE A . n 
A 1 304 ILE 304 294 294 ILE ILE A . n 
A 1 305 ILE 305 295 295 ILE ILE A . n 
A 1 306 ASN 306 296 296 ASN ASN A . n 
A 1 307 ASN 307 297 297 ASN ASN A . n 
A 1 308 ASP 308 298 298 ASP ASP A . n 
A 1 309 GLU 309 299 299 GLU GLU A . n 
A 1 310 LEU 310 300 300 LEU LEU A . n 
A 1 311 TYR 311 301 301 TYR TYR A . n 
A 1 312 VAL 312 302 302 VAL VAL A . n 
A 1 313 VAL 313 303 303 VAL VAL A . n 
A 1 314 PHE 314 304 304 PHE PHE A . n 
A 1 315 SER 315 305 305 SER SER A . n 
A 1 316 TYR 316 306 306 TYR TYR A . n 
A 1 317 GLU 317 307 307 GLU GLU A . n 
A 1 318 TYR 318 308 308 TYR TYR A . n 
A 1 319 GLU 319 309 309 GLU GLU A . n 
A 1 320 LEU 320 310 310 LEU LEU A . n 
A 1 321 GLU 321 311 311 GLU GLU A . n 
A 1 322 LYS 322 312 312 LYS LYS A . n 
A 1 323 GLU 323 313 313 GLU GLU A . n 
A 1 324 GLU 324 314 314 GLU GLU A . n 
A 1 325 ALA 325 315 315 ALA ALA A . n 
A 1 326 ASN 326 316 316 ASN ASN A . n 
A 1 327 PHE 327 317 317 PHE PHE A . n 
A 1 328 VAL 328 318 318 VAL VAL A . n 
A 1 329 LYS 329 319 319 LYS LYS A . n 
A 1 330 THR 330 320 320 THR THR A . n 
A 1 331 VAL 331 321 321 VAL VAL A . n 
A 1 332 GLY 332 322 322 GLY GLY A . n 
A 1 333 LEU 333 323 323 LEU LEU A . n 
A 1 334 ASP 334 324 324 ASP ASP A . n 
A 1 335 VAL 335 325 325 VAL VAL A . n 
A 1 336 ASN 336 326 326 ASN ASN A . n 
A 1 337 PHE 337 327 327 PHE PHE A . n 
A 1 338 LYS 338 328 328 LYS LYS A . n 
A 1 339 HIS 339 329 329 HIS HIS A . n 
A 1 340 ALA 340 330 330 ALA ALA A . n 
A 1 341 PHE 341 331 331 PHE PHE A . n 
A 1 342 PHE 342 332 332 PHE PHE A . n 
A 1 343 VAL 343 333 333 VAL VAL A . n 
A 1 344 THR 344 334 334 THR THR A . n 
A 1 345 SER 345 335 335 SER SER A . n 
A 1 346 GLU 346 336 336 GLU GLU A . n 
A 1 347 LYS 347 337 337 LYS LYS A . n 
A 1 348 ASP 348 338 338 ASP ASP A . n 
A 1 349 ASN 349 339 339 ASN ASN A . n 
A 1 350 CYS 350 340 340 CYS CYS A . n 
A 1 351 HIS 351 341 341 HIS HIS A . n 
A 1 352 LEU 352 342 342 LEU LEU A . n 
A 1 353 ASP 353 343 343 ASP ASP A . n 
A 1 354 GLY 354 344 344 GLY GLY A . n 
A 1 355 TYR 355 345 345 TYR TYR A . n 
A 1 356 ILE 356 346 346 ILE ILE A . n 
A 1 357 ASN 357 347 347 ASN ASN A . n 
A 1 358 LEU 358 348 348 LEU LEU A . n 
A 1 359 TYR 359 349 349 TYR TYR A . n 
A 1 360 LYS 360 350 350 LYS LYS A . n 
A 1 361 TYR 361 351 351 TYR TYR A . n 
A 1 362 LEU 362 352 352 LEU LEU A . n 
A 1 363 LEU 363 353 353 LEU LEU A . n 
A 1 364 GLU 364 354 354 GLU GLU A . n 
A 1 365 HIS 365 355 355 HIS HIS A . n 
A 1 366 ASP 366 356 356 ASP ASP A . n 
A 1 367 GLU 367 357 357 GLU GLU A . n 
A 1 368 PHE 368 358 358 PHE PHE A . n 
A 1 369 THR 369 359 359 THR THR A . n 
A 1 370 ASN 370 360 360 ASN ASN A . n 
A 1 371 LEU 371 361 361 LEU LEU A . n 
A 1 372 LEU 372 362 362 LEU LEU A . n 
A 1 373 THR 373 363 363 THR THR A . n 
A 1 374 ASN 374 364 364 ASN ASN A . n 
A 1 375 ASP 375 365 365 ASP ASP A . n 
A 1 376 GLU 376 366 366 GLU GLU A . n 
A 1 377 LYS 377 367 367 LYS LYS A . n 
A 1 378 LYS 378 368 368 LYS LYS A . n 
A 1 379 ASP 379 369 369 ASP ASP A . n 
A 1 380 TYR 380 370 370 TYR TYR A . n 
A 1 381 GLU 381 371 371 GLU GLU A . n 
A 1 382 GLU 382 372 372 GLU GLU A . n 
A 1 383 LEU 383 373 373 LEU LEU A . n 
A 1 384 SER 384 374 374 SER SER A . n 
A 1 385 LYS 385 375 375 LYS LYS A . n 
A 1 386 VAL 386 376 376 VAL VAL A . n 
A 1 387 VAL 387 377 377 VAL VAL A . n 
A 1 388 THR 388 378 378 THR THR A . n 
A 1 389 PHE 389 379 379 PHE PHE A . n 
A 1 390 CYS 390 380 380 CYS CYS A . n 
A 1 391 PRO 391 381 381 PRO PRO A . n 
A 1 392 PHE 392 382 382 PHE PHE A . n 
A 1 393 GLU 393 383 383 GLU GLU A . n 
A 1 394 ASN 394 384 384 ASN ASN A . n 
A 1 395 GLN 395 385 385 GLN GLN A . n 
A 1 396 LEU 396 386 386 LEU LEU A . n 
A 1 397 LEU 397 387 387 LEU LEU A . n 
A 1 398 PHE 398 388 388 PHE PHE A . n 
A 1 399 ALA 399 389 389 ALA ALA A . n 
A 1 400 ARG 400 390 390 ARG ARG A . n 
A 1 401 TYR 401 391 391 TYR TYR A . n 
A 1 402 ASN 402 392 392 ASN ASN A . n 
A 1 403 LYS 403 393 393 LYS LYS A . n 
A 1 404 MET 404 394 394 MET MET A . n 
A 1 405 SER 405 395 395 SER SER A . n 
A 1 406 LYS 406 396 396 LYS LYS A . n 
A 1 407 PHE 407 397 397 PHE PHE A . n 
A 1 408 CYS 408 398 398 CYS CYS A . n 
A 1 409 LYS 409 399 399 LYS LYS A . n 
A 1 410 LYS 410 400 400 LYS LYS A . n 
A 1 411 GLU 411 401 401 GLU GLU A . n 
A 1 412 GLN 412 402 402 GLN GLN A . n 
A 1 413 VAL 413 403 403 VAL VAL A . n 
A 1 414 LEU 414 404 404 LEU LEU A . n 
A 1 415 SER 415 405 405 SER SER A . n 
A 1 416 LYS 416 406 406 LYS LYS A . n 
A 1 417 LEU 417 407 407 LEU LEU A . n 
A 1 418 LEU 418 408 408 LEU LEU A . n 
A 1 419 TYR 419 409 409 TYR TYR A . n 
A 1 420 ALA 420 410 410 ALA ALA A . n 
A 1 421 LEU 421 411 411 LEU LEU A . n 
A 1 422 GLN 422 412 412 GLN GLN A . n 
A 1 423 LYS 423 413 413 LYS LYS A . n 
A 1 424 GLN 424 414 414 GLN GLN A . n 
A 1 425 LEU 425 415 415 LEU LEU A . n 
A 1 426 LYS 426 416 416 LYS LYS A . n 
A 1 427 ASP 427 417 417 ASP ASP A . n 
A 1 428 GLU 428 418 418 GLU GLU A . n 
A 1 429 ASN 429 419 419 ASN ASN A . n 
A 1 430 ARG 430 420 420 ARG ARG A . n 
A 1 431 THR 431 421 421 THR THR A . n 
A 1 432 LYS 432 422 422 LYS LYS A . n 
A 1 433 GLU 433 423 423 GLU GLU A . n 
A 1 434 TYR 434 424 424 TYR TYR A . n 
A 1 435 ILE 435 425 425 ILE ILE A . n 
A 1 436 TYR 436 426 426 TYR TYR A . n 
A 1 437 VAL 437 427 427 VAL VAL A . n 
A 1 438 SER 438 428 428 SER SER A . n 
A 1 439 CYS 439 429 429 CYS CYS A . n 
A 1 440 VAL 440 430 430 VAL VAL A . n 
A 1 441 ASN 441 431 431 ASN ASN A . n 
A 1 442 LYS 442 432 432 LYS LYS A . n 
A 1 443 LEU 443 433 433 LEU LEU A . n 
A 1 444 ARG 444 434 434 ARG ARG A . n 
A 1 445 ALA 445 435 435 ALA ALA A . n 
A 1 446 LYS 446 436 436 LYS LYS A . n 
A 1 447 TYR 447 437 437 TYR TYR A . n 
A 1 448 VAL 448 438 438 VAL VAL A . n 
A 1 449 SER 449 439 439 SER SER A . n 
A 1 450 TYR 450 440 440 TYR TYR A . n 
A 1 451 PHE 451 441 441 PHE PHE A . n 
A 1 452 ILE 452 442 442 ILE ILE A . n 
A 1 453 LEU 453 443 443 LEU LEU A . n 
A 1 454 LYS 454 444 444 LYS LYS A . n 
A 1 455 GLU 455 445 445 GLU GLU A . n 
A 1 456 LYS 456 446 446 LYS LYS A . n 
A 1 457 TYR 457 447 447 TYR TYR A . n 
A 1 458 TYR 458 448 448 TYR TYR A . n 
A 1 459 GLU 459 449 449 GLU GLU A . n 
A 1 460 LYS 460 450 450 LYS LYS A . n 
A 1 461 GLN 461 451 451 GLN GLN A . n 
A 1 462 LYS 462 452 452 LYS LYS A . n 
A 1 463 GLU 463 453 453 GLU GLU A . n 
A 1 464 TYR 464 454 454 TYR TYR A . n 
A 1 465 ASP 465 455 455 ASP ASP A . n 
A 1 466 ILE 466 456 456 ILE ILE A . n 
A 1 467 GLU 467 457 457 GLU GLU A . n 
A 1 468 MET 468 458 458 MET MET A . n 
A 1 469 GLY 469 459 459 GLY GLY A . n 
A 1 470 PHE 470 460 460 PHE PHE A . n 
A 1 471 VAL 471 461 461 VAL VAL A . n 
A 1 472 ASP 472 462 462 ASP ASP A . n 
A 1 473 ASP 473 463 463 ASP ASP A . n 
A 1 474 SER 474 464 464 SER SER A . n 
A 1 475 THR 475 465 465 THR THR A . n 
A 1 476 GLU 476 466 466 GLU GLU A . n 
A 1 477 SER 477 467 467 SER SER A . n 
A 1 478 LYS 478 468 468 LYS LYS A . n 
A 1 479 GLU 479 469 469 GLU GLU A . n 
A 1 480 SER 480 470 470 SER SER A . n 
A 1 481 MET 481 471 471 MET MET A . n 
A 1 482 ASP 482 472 472 ASP ASP A . n 
A 1 483 LYS 483 473 473 LYS LYS A . n 
A 1 484 ARG 484 474 474 ARG ARG A . n 
A 1 485 ARG 485 475 475 ARG ARG A . n 
A 1 486 THR 486 476 476 THR THR A . n 
A 1 487 GLU 487 477 477 GLU GLU A . n 
A 1 488 PHE 488 478 478 PHE PHE A . n 
A 1 489 PRO 489 479 479 PRO PRO A . n 
A 1 490 PHE 490 480 480 PHE PHE A . n 
A 1 491 ARG 491 481 481 ARG ARG A . n 
A 1 492 ASN 492 482 482 ASN ASN A . n 
A 1 493 THR 493 483 483 THR THR A . n 
A 1 494 PRO 494 484 484 PRO PRO A . n 
A 1 495 VAL 495 485 485 VAL VAL A . n 
A 1 496 ALA 496 486 486 ALA ALA A . n 
A 1 497 ASN 497 487 487 ASN ASN A . n 
A 1 498 GLU 498 488 488 GLU GLU A . n 
A 1 499 LEU 499 489 489 LEU LEU A . n 
A 1 500 LEU 500 490 490 LEU LEU A . n 
A 1 501 SER 501 491 491 SER SER A . n 
A 1 502 LYS 502 492 492 LYS LYS A . n 
A 1 503 LEU 503 493 493 LEU LEU A . n 
A 1 504 ASN 504 494 494 ASN ASN A . n 
A 1 505 ASN 505 495 495 ASN ASN A . n 
A 1 506 VAL 506 496 496 VAL VAL A . n 
A 1 507 GLN 507 497 497 GLN GLN A . n 
A 1 508 GLN 508 498 498 GLN GLN A . n 
A 1 509 ASP 509 499 499 ASP ASP A . n 
A 1 510 ILE 510 500 500 ILE ILE A . n 
A 1 511 ASN 511 501 501 ASN ASN A . n 
A 1 512 GLY 512 502 502 GLY GLY A . n 
A 1 513 CYS 513 503 503 CYS CYS A . n 
A 1 514 LEU 514 504 504 LEU LEU A . n 
A 1 515 LYS 515 505 505 LYS LYS A . n 
A 1 516 ASN 516 506 506 ASN ASN A . n 
A 1 517 ILE 517 507 507 ILE ILE A . n 
A 1 518 ILE 518 508 508 ILE ILE A . n 
A 1 519 ASN 519 509 509 ASN ASN A . n 
A 1 520 TYR 520 510 510 TYR TYR A . n 
A 1 521 ILE 521 511 511 ILE ILE A . n 
A 1 522 TYR 522 512 512 TYR TYR A . n 
A 1 523 LYS 523 513 513 LYS LYS A . n 
A 1 524 ILE 524 514 514 ILE ILE A . n 
A 1 525 PHE 525 515 515 PHE PHE A . n 
A 1 526 GLU 526 516 516 GLU GLU A . n 
A 1 527 GLN 527 517 517 GLN GLN A . n 
A 1 528 ASN 528 518 518 ASN ASN A . n 
A 1 529 GLY 529 519 519 GLY GLY A . n 
A 1 530 TYR 530 520 520 TYR TYR A . n 
A 1 531 LYS 531 521 521 LYS LYS A . n 
A 1 532 ILE 532 522 522 ILE ILE A . n 
A 1 533 VAL 533 523 523 VAL VAL A . n 
A 1 534 ALA 534 524 524 ALA ALA A . n 
A 1 535 LEU 535 525 525 LEU LEU A . n 
A 1 536 GLU 536 526 526 GLU GLU A . n 
A 1 537 ASN 537 527 527 ASN ASN A . n 
A 1 538 LEU 538 528 ?   ?   ?   A . n 
A 1 539 GLU 539 529 ?   ?   ?   A . n 
A 1 540 ASN 540 530 ?   ?   ?   A . n 
A 1 541 SER 541 531 ?   ?   ?   A . n 
A 1 542 ASN 542 532 ?   ?   ?   A . n 
A 1 543 PHE 543 533 533 PHE PHE A . n 
A 1 544 GLU 544 534 534 GLU GLU A . n 
A 1 545 LYS 545 535 535 LYS LYS A . n 
A 1 546 LYS 546 536 536 LYS LYS A . n 
A 1 547 GLN 547 537 537 GLN GLN A . n 
A 1 548 VAL 548 538 538 VAL VAL A . n 
A 1 549 LEU 549 539 539 LEU LEU A . n 
A 1 550 PRO 550 540 540 PRO PRO A . n 
A 1 551 THR 551 541 541 THR THR A . n 
A 1 552 ILE 552 542 542 ILE ILE A . n 
A 1 553 LYS 553 543 543 LYS LYS A . n 
A 1 554 SER 554 544 544 SER SER A . n 
A 1 555 LEU 555 545 545 LEU LEU A . n 
A 1 556 LEU 556 546 546 LEU LEU A . n 
A 1 557 LYS 557 547 547 LYS LYS A . n 
A 1 558 TYR 558 548 548 TYR TYR A . n 
A 1 559 HIS 559 549 549 HIS HIS A . n 
A 1 560 LYS 560 550 550 LYS LYS A . n 
A 1 561 LEU 561 551 551 LEU LEU A . n 
A 1 562 GLU 562 552 552 GLU GLU A . n 
A 1 563 ASN 563 553 553 ASN ASN A . n 
A 1 564 GLN 564 554 554 GLN GLN A . n 
A 1 565 ASN 565 555 555 ASN ASN A . n 
A 1 566 VAL 566 556 556 VAL VAL A . n 
A 1 567 ASN 567 557 557 ASN ASN A . n 
A 1 568 ASP 568 558 558 ASP ASP A . n 
A 1 569 ILE 569 559 559 ILE ILE A . n 
A 1 570 LYS 570 560 560 LYS LYS A . n 
A 1 571 ALA 571 561 561 ALA ALA A . n 
A 1 572 SER 572 562 562 SER SER A . n 
A 1 573 ASP 573 563 563 ASP ASP A . n 
A 1 574 LYS 574 564 564 LYS LYS A . n 
A 1 575 VAL 575 565 565 VAL VAL A . n 
A 1 576 LYS 576 566 566 LYS LYS A . n 
A 1 577 GLU 577 567 567 GLU GLU A . n 
A 1 578 TYR 578 568 568 TYR TYR A . n 
A 1 579 ILE 579 569 569 ILE ILE A . n 
A 1 580 GLU 580 570 570 GLU GLU A . n 
A 1 581 ASN 581 571 571 ASN ASN A . n 
A 1 582 GLY 582 572 572 GLY GLY A . n 
A 1 583 TYR 583 573 573 TYR TYR A . n 
A 1 584 TYR 584 574 574 TYR TYR A . n 
A 1 585 GLU 585 575 575 GLU GLU A . n 
A 1 586 LEU 586 576 576 LEU LEU A . n 
A 1 587 ILE 587 577 577 ILE ILE A . n 
A 1 588 THR 588 578 578 THR THR A . n 
A 1 589 ASN 589 579 579 ASN ASN A . n 
A 1 590 GLU 590 580 580 GLU GLU A . n 
A 1 591 ASN 591 581 581 ASN ASN A . n 
A 1 592 ASN 592 582 582 ASN ASN A . n 
A 1 593 GLU 593 583 583 GLU GLU A . n 
A 1 594 ILE 594 584 584 ILE ILE A . n 
A 1 595 VAL 595 585 585 VAL VAL A . n 
A 1 596 ASP 596 586 586 ASP ASP A . n 
A 1 597 ALA 597 587 587 ALA ALA A . n 
A 1 598 LYS 598 588 588 LYS LYS A . n 
A 1 599 TYR 599 589 589 TYR TYR A . n 
A 1 600 THR 600 590 590 THR THR A . n 
A 1 601 GLU 601 591 591 GLU GLU A . n 
A 1 602 LYS 602 592 592 LYS LYS A . n 
A 1 603 GLY 603 593 593 GLY GLY A . n 
A 1 604 ALA 604 594 594 ALA ALA A . n 
A 1 605 MET 605 595 595 MET MET A . n 
A 1 606 LYS 606 596 596 LYS LYS A . n 
A 1 607 VAL 607 597 597 VAL VAL A . n 
A 1 608 LYS 608 598 598 LYS LYS A . n 
A 1 609 ASN 609 599 599 ASN ASN A . n 
A 1 610 ALA 610 600 600 ALA ALA A . n 
A 1 611 ASN 611 601 601 ASN ASN A . n 
A 1 612 PHE 612 602 602 PHE PHE A . n 
A 1 613 PHE 613 603 603 PHE PHE A . n 
A 1 614 ASN 614 604 604 ASN ASN A . n 
A 1 615 LEU 615 605 605 LEU LEU A . n 
A 1 616 MET 616 606 606 MET MET A . n 
A 1 617 MET 617 607 607 MET MET A . n 
A 1 618 LYS 618 608 608 LYS LYS A . n 
A 1 619 SER 619 609 609 SER SER A . n 
A 1 620 LEU 620 610 610 LEU LEU A . n 
A 1 621 HIS 621 611 611 HIS HIS A . n 
A 1 622 PHE 622 612 612 PHE PHE A . n 
A 1 623 ALA 623 613 613 ALA ALA A . n 
A 1 624 SER 624 614 614 SER SER A . n 
A 1 625 VAL 625 615 615 VAL VAL A . n 
A 1 626 LYS 626 616 616 LYS LYS A . n 
A 1 627 ASP 627 617 617 ASP ASP A . n 
A 1 628 GLU 628 618 618 GLU GLU A . n 
A 1 629 PHE 629 619 619 PHE PHE A . n 
A 1 630 VAL 630 620 620 VAL VAL A . n 
A 1 631 LEU 631 621 621 LEU LEU A . n 
A 1 632 LEU 632 622 622 LEU LEU A . n 
A 1 633 SER 633 623 623 SER SER A . n 
A 1 634 ASN 634 624 624 ASN ASN A . n 
A 1 635 ASN 635 625 625 ASN ASN A . n 
A 1 636 GLY 636 626 626 GLY GLY A . n 
A 1 637 LYS 637 627 627 LYS LYS A . n 
A 1 638 THR 638 628 628 THR THR A . n 
A 1 639 GLN 639 629 629 GLN GLN A . n 
A 1 640 ILE 640 630 630 ILE ILE A . n 
A 1 641 ALA 641 631 631 ALA ALA A . n 
A 1 642 LEU 642 632 632 LEU LEU A . n 
A 1 643 VAL 643 633 633 VAL VAL A . n 
A 1 644 PRO 644 634 ?   ?   ?   A . n 
A 1 645 SER 645 635 ?   ?   ?   A . n 
A 1 646 GLU 646 636 ?   ?   ?   A . n 
A 1 647 PHE 647 637 ?   ?   ?   A . n 
A 1 648 THR 648 638 ?   ?   ?   A . n 
A 1 649 SER 649 639 ?   ?   ?   A . n 
A 1 650 GLN 650 640 ?   ?   ?   A . n 
A 1 651 MET 651 641 ?   ?   ?   A . n 
A 1 652 ASP 652 642 ?   ?   ?   A . n 
A 1 653 SER 653 643 ?   ?   ?   A . n 
A 1 654 THR 654 644 ?   ?   ?   A . n 
A 1 655 ASP 655 645 ?   ?   ?   A . n 
A 1 656 HIS 656 646 ?   ?   ?   A . n 
A 1 657 CYS 657 647 ?   ?   ?   A . n 
A 1 658 LEU 658 648 ?   ?   ?   A . n 
A 1 659 TYR 659 649 ?   ?   ?   A . n 
A 1 660 MET 660 650 ?   ?   ?   A . n 
A 1 661 LYS 661 651 ?   ?   ?   A . n 
A 1 662 LYS 662 652 ?   ?   ?   A . n 
A 1 663 ASN 663 653 ?   ?   ?   A . n 
A 1 664 ASP 664 654 ?   ?   ?   A . n 
A 1 665 LYS 665 655 ?   ?   ?   A . n 
A 1 666 GLY 666 656 ?   ?   ?   A . n 
A 1 667 LYS 667 657 ?   ?   ?   A . n 
A 1 668 LEU 668 658 ?   ?   ?   A . n 
A 1 669 VAL 669 659 ?   ?   ?   A . n 
A 1 670 LYS 670 660 ?   ?   ?   A . n 
A 1 671 ALA 671 661 ?   ?   ?   A . n 
A 1 672 ASP 672 662 ?   ?   ?   A . n 
A 1 673 LYS 673 663 ?   ?   ?   A . n 
A 1 674 LYS 674 664 ?   ?   ?   A . n 
A 1 675 GLU 675 665 ?   ?   ?   A . n 
A 1 676 VAL 676 666 ?   ?   ?   A . n 
A 1 677 ARG 677 667 ?   ?   ?   A . n 
A 1 678 THR 678 668 ?   ?   ?   A . n 
A 1 679 LYS 679 669 ?   ?   ?   A . n 
A 1 680 GLN 680 670 ?   ?   ?   A . n 
A 1 681 GLU 681 671 ?   ?   ?   A . n 
A 1 682 LYS 682 672 ?   ?   ?   A . n 
A 1 683 HIS 683 673 ?   ?   ?   A . n 
A 1 684 ILE 684 674 ?   ?   ?   A . n 
A 1 685 ASN 685 675 ?   ?   ?   A . n 
A 1 686 GLY 686 676 ?   ?   ?   A . n 
A 1 687 LEU 687 677 ?   ?   ?   A . n 
A 1 688 ASN 688 678 ?   ?   ?   A . n 
A 1 689 ALA 689 679 ?   ?   ?   A . n 
A 1 690 ASP 690 680 ?   ?   ?   A . n 
A 1 691 PHE 691 681 ?   ?   ?   A . n 
A 1 692 ASN 692 682 ?   ?   ?   A . n 
A 1 693 ALA 693 683 ?   ?   ?   A . n 
A 1 694 ALA 694 684 ?   ?   ?   A . n 
A 1 695 ASN 695 685 ?   ?   ?   A . n 
A 1 696 ASN 696 686 ?   ?   ?   A . n 
A 1 697 ILE 697 687 ?   ?   ?   A . n 
A 1 698 LYS 698 688 ?   ?   ?   A . n 
A 1 699 TYR 699 689 ?   ?   ?   A . n 
A 1 700 ILE 700 690 ?   ?   ?   A . n 
A 1 701 VAL 701 691 ?   ?   ?   A . n 
A 1 702 GLU 702 692 ?   ?   ?   A . n 
A 1 703 ASN 703 693 ?   ?   ?   A . n 
A 1 704 GLU 704 694 ?   ?   ?   A . n 
A 1 705 VAL 705 695 ?   ?   ?   A . n 
A 1 706 TRP 706 696 ?   ?   ?   A . n 
A 1 707 ARG 707 697 ?   ?   ?   A . n 
A 1 708 GLU 708 698 ?   ?   ?   A . n 
A 1 709 ILE 709 699 ?   ?   ?   A . n 
A 1 710 PHE 710 700 ?   ?   ?   A . n 
A 1 711 CYS 711 701 ?   ?   ?   A . n 
A 1 712 THR 712 702 ?   ?   ?   A . n 
A 1 713 ARG 713 703 ?   ?   ?   A . n 
A 1 714 PRO 714 704 ?   ?   ?   A . n 
A 1 715 LYS 715 705 ?   ?   ?   A . n 
A 1 716 LYS 716 706 ?   ?   ?   A . n 
A 1 717 ALA 717 707 ?   ?   ?   A . n 
A 1 718 GLU 718 708 ?   ?   ?   A . n 
A 1 719 TYR 719 709 ?   ?   ?   A . n 
A 1 720 ASN 720 710 ?   ?   ?   A . n 
A 1 721 VAL 721 711 ?   ?   ?   A . n 
A 1 722 PRO 722 712 ?   ?   ?   A . n 
A 1 723 SER 723 713 ?   ?   ?   A . n 
A 1 724 LEU 724 714 ?   ?   ?   A . n 
A 1 725 ASP 725 715 ?   ?   ?   A . n 
A 1 726 THR 726 716 ?   ?   ?   A . n 
A 1 727 THR 727 717 ?   ?   ?   A . n 
A 1 728 LYS 728 718 ?   ?   ?   A . n 
A 1 729 LYS 729 719 ?   ?   ?   A . n 
A 1 730 GLY 730 720 ?   ?   ?   A . n 
A 1 731 PRO 731 721 ?   ?   ?   A . n 
A 1 732 SER 732 722 ?   ?   ?   A . n 
A 1 733 ALA 733 723 ?   ?   ?   A . n 
A 1 734 ILE 734 724 ?   ?   ?   A . n 
A 1 735 LEU 735 725 ?   ?   ?   A . n 
A 1 736 HIS 736 726 ?   ?   ?   A . n 
A 1 737 MET 737 727 ?   ?   ?   A . n 
A 1 738 LEU 738 728 ?   ?   ?   A . n 
A 1 739 LYS 739 729 ?   ?   ?   A . n 
A 1 740 LYS 740 730 ?   ?   ?   A . n 
A 1 741 ILE 741 731 ?   ?   ?   A . n 
A 1 742 GLU 742 732 ?   ?   ?   A . n 
A 1 743 ALA 743 733 ?   ?   ?   A . n 
A 1 744 ILE 744 734 ?   ?   ?   A . n 
A 1 745 LYS 745 735 ?   ?   ?   A . n 
A 1 746 ILE 746 736 ?   ?   ?   A . n 
A 1 747 LEU 747 737 ?   ?   ?   A . n 
A 1 748 GLU 748 738 ?   ?   ?   A . n 
A 1 749 THR 749 739 ?   ?   ?   A . n 
A 1 750 GLU 750 740 ?   ?   ?   A . n 
A 1 751 LYS 751 741 ?   ?   ?   A . n 
B 2 1   G   1   -38 ?   ?   ?   B . n 
B 2 2   G   2   -37 ?   ?   ?   B . n 
B 2 3   C   3   -36 -36 C   C   B . n 
B 2 4   U   4   -35 -35 U   U   B . n 
B 2 5   U   5   -34 -34 U   U   B . n 
B 2 6   G   6   -33 -33 G   G   B . n 
B 2 7   U   7   -32 -32 U   U   B . n 
B 2 8   U   8   -31 -31 U   U   B . n 
B 2 9   G   9   -30 -30 G   G   B . n 
B 2 10  U   10  -29 -29 U   U   B . n 
B 2 11  A   11  -28 -28 A   A   B . n 
B 2 12  U   12  -27 -27 U   U   B . n 
B 2 13  A   13  -26 -26 A   A   B . n 
B 2 14  U   14  -25 -25 U   U   B . n 
B 2 15  A   15  -24 -24 A   A   B . n 
B 2 16  U   16  -23 -23 U   U   B . n 
B 2 17  U   17  -22 -22 U   U   B . n 
B 2 18  C   18  -21 -21 C   C   B . n 
B 2 19  U   19  -20 -20 U   U   B . n 
B 2 20  U   20  -19 -19 U   U   B . n 
B 2 21  U   21  -18 -18 U   U   B . n 
B 2 22  U   22  -17 -17 U   U   B . n 
B 2 23  A   23  -16 -16 A   A   B . n 
B 2 24  U   24  -15 -15 U   U   B . n 
B 2 25  A   25  -14 -14 A   A   B . n 
B 2 26  G   26  -13 -13 G   G   B . n 
B 2 27  G   27  -12 -12 G   G   B . n 
B 2 28  U   28  -11 -11 U   U   B . n 
B 2 29  A   29  -10 -10 A   A   B . n 
B 2 30  U   30  -9  -9  U   U   B . n 
B 2 31  U   31  -8  -8  U   U   B . n 
B 2 32  A   32  -7  -7  A   A   B . n 
B 2 33  A   33  -6  -6  A   A   B . n 
B 2 34  A   34  -5  -5  A   A   B . n 
B 2 35  C   35  -4  -4  C   C   B . n 
B 2 36  A   36  -3  -3  A   A   B . n 
B 2 37  A   37  -2  -2  A   A   B . n 
B 2 38  C   38  -1  -1  C   C   B . n 
B 2 39  G   39  0   0   G   G   B . n 
B 2 40  G   40  1   1   G   G   B . n 
B 2 41  A   41  2   2   A   A   B . n 
B 2 42  G   42  3   3   G   G   B . n 
B 2 43  A   43  4   4   A   A   B . n 
B 2 44  U   44  5   5   U   U   B . n 
B 2 45  G   45  6   6   G   G   B . n 
B 2 46  A   46  7   7   A   A   B . n 
B 2 47  G   47  8   8   G   G   B . n 
B 2 48  G   48  9   9   G   G   B . n 
B 2 49  U   49  10  10  U   U   B . n 
B 2 50  G   50  11  11  G   G   B . n 
B 2 51  C   51  12  12  C   C   B . n 
B 2 52  G   52  13  13  G   G   B . n 
B 2 53  C   53  14  14  C   C   B . n 
B 2 54  G   54  15  15  G   G   B . n 
B 2 55  U   55  16  16  U   U   B . n 
B 2 56  G   56  17  ?   ?   ?   B . n 
B 2 57  G   57  18  ?   ?   ?   B . n 
B 2 58  C   58  19  ?   ?   ?   B . n 
C 3 1   DT  1   -10 -10 DT  DT  C . n 
C 3 2   DG  2   -9  -9  DG  DG  C . n 
C 3 3   DT  3   -8  -8  DT  DT  C . n 
C 3 4   DC  4   -7  -7  DC  DC  C . n 
C 3 5   DT  5   -6  -6  DT  DT  C . n 
C 3 6   DA  6   -5  -5  DA  DA  C . n 
C 3 7   DT  7   -4  -4  DT  DT  C . n 
C 3 8   DT  8   -3  -3  DT  DT  C . n 
C 3 9   DT  9   -2  -2  DT  DT  C . n 
C 3 10  DA  10  -1  -1  DA  DA  C . n 
C 3 11  DG  11  0   0   DG  DG  C . n 
C 3 12  DG  12  1   1   DG  DG  C . n 
C 3 13  DA  13  2   2   DA  DA  C . n 
C 3 14  DG  14  3   ?   ?   ?   C . n 
C 3 15  DA  15  4   ?   ?   ?   C . n 
C 3 16  DT  16  5   ?   ?   ?   C . n 
C 3 17  DG  17  6   ?   ?   ?   C . n 
C 3 18  DA  18  7   ?   ?   ?   C . n 
C 3 19  DG  19  8   ?   ?   ?   C . n 
C 3 20  DG  20  9   ?   ?   ?   C . n 
C 3 21  DT  21  10  ?   ?   ?   C . n 
C 3 22  DG  22  11  ?   ?   ?   C . n 
C 3 23  DC  23  12  ?   ?   ?   C . n 
C 3 24  DG  24  13  ?   ?   ?   C . n 
C 3 25  DC  25  14  ?   ?   ?   C . n 
C 3 26  DG  26  15  ?   ?   ?   C . n 
C 3 27  DT  27  16  ?   ?   ?   C . n 
C 3 28  DG  28  17  ?   ?   ?   C . n 
C 3 29  GS  29  18  ?   ?   ?   C . n 
C 3 30  SC  30  19  ?   ?   ?   C . n 
C 3 31  AS  31  20  ?   ?   ?   C . n 
C 3 32  SC  32  21  ?   ?   ?   C . n 
C 3 33  SC  33  22  ?   ?   ?   C . n 
C 3 34  AS  34  23  ?   ?   ?   C . n 
C 3 35  PST 35  24  ?   ?   ?   C . n 
C 3 36  SC  36  25  ?   ?   ?   C . n 
C 3 37  AS  37  26  ?   ?   ?   C . n 
C 3 38  PST 38  27  ?   ?   ?   C . n 
C 3 39  AS  39  28  ?   ?   ?   C . n 
C 3 40  PST 40  29  ?   ?   ?   C . n 
D 4 1   AS  1   -9  ?   ?   ?   D . n 
D 4 2   PST 2   -8  ?   ?   ?   D . n 
D 4 3   AS  3   -7  ?   ?   ?   D . n 
D 4 4   PST 4   -6  ?   ?   ?   D . n 
D 4 5   GS  5   -5  ?   ?   ?   D . n 
D 4 6   AS  6   -4  ?   ?   ?   D . n 
D 4 7   PST 7   -3  ?   ?   ?   D . n 
D 4 8   GS  8   -2  ?   ?   ?   D . n 
D 4 9   GS  9   -1  ?   ?   ?   D . n 
D 4 10  PST 10  0   ?   ?   ?   D . n 
D 4 11  GS  11  1   ?   ?   ?   D . n 
D 4 12  SC  12  2   ?   ?   ?   D . n 
D 4 13  DC  13  3   ?   ?   ?   D . n 
D 4 14  DA  14  4   4   DA  DA  D . n 
D 4 15  DC  15  5   5   DC  DC  D . n 
D 4 16  DG  16  6   6   DG  DG  D . n 
D 4 17  DC  17  7   7   DC  DC  D . n 
D 4 18  DG  18  8   8   DG  DG  D . n 
D 4 19  DC  19  9   9   DC  DC  D . n 
D 4 20  DA  20  10  10  DA  DA  D . n 
D 4 21  DC  21  11  11  DC  DC  D . n 
D 4 22  DC  22  12  12  DC  DC  D . n 
D 4 23  DT  23  13  13  DT  DT  D . n 
D 4 24  DC  24  14  14  DC  DC  D . n 
D 4 25  DA  25  15  15  DA  DA  D . n 
D 4 26  DT  26  16  16  DT  DT  D . n 
D 4 27  DC  27  17  17  DC  DC  D . n 
D 4 28  DT  28  18  18  DT  DT  D . n 
D 4 29  DC  29  19  19  DC  DC  D . n 
D 4 30  DC  30  20  20  DC  DC  D . n 
D 4 31  DT  31  21  21  DT  DT  D . n 
D 4 32  DA  32  22  22  DA  DA  D . n 
D 4 33  DA  33  23  23  DA  DA  D . n 
D 4 34  DA  34  24  24  DA  DA  D . n 
D 4 35  DT  35  25  25  DT  DT  D . n 
D 4 36  DA  36  26  26  DA  DA  D . n 
D 4 37  DG  37  27  27  DG  DG  D . n 
D 4 38  DA  38  28  28  DA  DA  D . n 
D 4 39  DC  39  29  29  DC  DC  D . n 
D 4 40  DA  40  30  30  DA  DA  D . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
E 5 MG 1 801 2 MG MG A . 
F 5 MG 1 101 3 MG MG B . 
G 5 MG 1 102 4 MG MG B . 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9IZP 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9IZP 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9IZP 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.entry_id                                 9IZP 
_refine.pdbx_diffrn_id                           ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             ? 
_refine.ls_d_res_high                            . 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.B_iso_mean                               ? 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.details                                  ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.overall_SU_ML                            ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.005  ? 7510  ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 0.545  ? 10530 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 20.003 ? 1857  ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.041  ? 1198  ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.003  ? 1005  ? f_plane_restr      ? ? 
# 
_struct.entry_id                     9IZP 
_struct.title                        'Cryo-EM structure of CasLambda2-crRNA-target DNA ternary complex in the incompetent state' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9IZP 
_struct_keywords.text            'CRISPR-CAS12, GENOME ENGINEERING, HYDROLASE-RNA-DNA COMPLEX, DNA BINDING PROTEIN' 
_struct_keywords.pdbx_keywords   'DNA BINDING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 5 ? 
F N N 5 ? 
G N N 5 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 PDB 9IZP 9IZP ? 1 ? 1 
2 PDB 9IZP 9IZP ? 2 ? 1 
3 PDB 9IZP 9IZP ? 3 ? 1 
4 PDB 9IZP 9IZP ? 4 ? 1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9IZP A 1 ? 751 ? 9IZP -9  ? 741 ? -9  741 
2 2 9IZP B 1 ? 58  ? 9IZP -38 ? 19  ? -38 19  
3 3 9IZP C 1 ? 40  ? 9IZP -10 ? 29  ? -10 29  
4 4 9IZP D 1 ? 40  ? 9IZP -9  ? 30  ? -9  30  
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   tetrameric 
_pdbx_struct_assembly.oligomeric_count     4 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 THR A 26  ? ASN A 47  ? THR A 16  ASN A 37  1 ? 22 
HELX_P HELX_P2  AA2 THR A 52  ? GLY A 65  ? THR A 42  GLY A 55  1 ? 14 
HELX_P HELX_P3  AA3 VAL A 68  ? MET A 73  ? VAL A 58  MET A 63  1 ? 6  
HELX_P HELX_P4  AA4 PRO A 83  ? THR A 89  ? PRO A 73  THR A 79  5 ? 7  
HELX_P HELX_P5  AA5 HIS A 93  ? ASN A 109 ? HIS A 83  ASN A 99  1 ? 17 
HELX_P HELX_P6  AA6 GLY A 121 ? ARG A 126 ? GLY A 111 ARG A 116 1 ? 6  
HELX_P HELX_P7  AA7 GLY A 129 ? THR A 144 ? GLY A 119 THR A 134 1 ? 16 
HELX_P HELX_P8  AA8 THR A 159 ? ASN A 175 ? THR A 149 ASN A 165 1 ? 17 
HELX_P HELX_P9  AA9 LYS A 178 ? ASN A 191 ? LYS A 168 ASN A 181 1 ? 14 
HELX_P HELX_P10 AB1 ASN A 196 ? ASN A 213 ? ASN A 186 ASN A 203 1 ? 18 
HELX_P HELX_P11 AB2 ASN A 213 ? GLN A 228 ? ASN A 203 GLN A 218 1 ? 16 
HELX_P HELX_P12 AB3 THR A 287 ? TYR A 297 ? THR A 277 TYR A 287 1 ? 11 
HELX_P HELX_P13 AB4 ASN A 357 ? LEU A 363 ? ASN A 347 LEU A 353 1 ? 7  
HELX_P HELX_P14 AB5 HIS A 365 ? ASN A 370 ? HIS A 355 ASN A 360 1 ? 6  
HELX_P HELX_P15 AB6 THR A 373 ? LYS A 385 ? THR A 363 LYS A 375 1 ? 13 
HELX_P HELX_P16 AB7 GLU A 393 ? PHE A 398 ? GLU A 383 PHE A 388 1 ? 6  
HELX_P HELX_P17 AB8 ALA A 399 ? TYR A 401 ? ALA A 389 TYR A 391 5 ? 3  
HELX_P HELX_P18 AB9 PHE A 407 ? GLU A 428 ? PHE A 397 GLU A 418 1 ? 22 
HELX_P HELX_P19 AC1 ARG A 430 ? GLY A 469 ? ARG A 420 GLY A 459 1 ? 40 
HELX_P HELX_P20 AC2 SER A 477 ? ASP A 482 ? SER A 467 ASP A 472 5 ? 6  
HELX_P HELX_P21 AC3 LYS A 483 ? PHE A 488 ? LYS A 473 PHE A 478 1 ? 6  
HELX_P HELX_P22 AC4 THR A 493 ? GLN A 527 ? THR A 483 GLN A 517 1 ? 35 
HELX_P HELX_P23 AC5 THR A 551 ? TYR A 558 ? THR A 541 TYR A 548 1 ? 8  
HELX_P HELX_P24 AC6 SER A 572 ? ASN A 581 ? SER A 562 ASN A 571 1 ? 10 
HELX_P HELX_P25 AC7 THR A 600 ? LEU A 620 ? THR A 590 LEU A 610 1 ? 21 
HELX_P HELX_P26 AC8 SER A 624 ? ASN A 634 ? SER A 614 ASN A 624 1 ? 11 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1  metalc ? ? A ASP 509 OD1 ? ? ? 1_555 E MG .  MG ? ? A ASP 499 A MG 801 1_555 ? ? ? ? ? ? ?            2.100 ? ? 
metalc2  metalc ? ? B G   9   OP1 ? ? ? 1_555 E MG .  MG ? ? B G   -30 A MG 801 1_555 ? ? ? ? ? ? ?            1.984 ? ? 
metalc3  metalc ? ? B U   16  O4  ? ? ? 1_555 G MG .  MG ? ? B U   -23 B MG 102 1_555 ? ? ? ? ? ? ?            2.149 ? ? 
hydrog1  hydrog ? ? B G   6   N1  ? ? ? 1_555 B C  38 N3 ? ? B G   -33 B C  -1  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog2  hydrog ? ? B G   6   N2  ? ? ? 1_555 B C  38 O2 ? ? B G   -33 B C  -1  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog3  hydrog ? ? B G   6   O6  ? ? ? 1_555 B C  38 N4 ? ? B G   -33 B C  -1  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog4  hydrog ? ? B U   7   N3  ? ? ? 1_555 B A  37 N1 ? ? B U   -32 B A  -2  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog5  hydrog ? ? B U   7   O4  ? ? ? 1_555 B A  37 N6 ? ? B U   -32 B A  -2  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog6  hydrog ? ? B U   8   N3  ? ? ? 1_555 B A  36 N1 ? ? B U   -31 B A  -3  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog7  hydrog ? ? B U   8   O4  ? ? ? 1_555 B A  36 N6 ? ? B U   -31 B A  -3  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog8  hydrog ? ? B G   9   N1  ? ? ? 1_555 B C  35 N3 ? ? B G   -30 B C  -4  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog9  hydrog ? ? B G   9   N2  ? ? ? 1_555 B C  35 O2 ? ? B G   -30 B C  -4  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog10 hydrog ? ? B G   9   O6  ? ? ? 1_555 B C  35 N4 ? ? B G   -30 B C  -4  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog11 hydrog ? ? B U   10  N3  ? ? ? 1_555 B A  34 N1 ? ? B U   -29 B A  -5  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog12 hydrog ? ? B U   10  O4  ? ? ? 1_555 B A  34 N6 ? ? B U   -29 B A  -5  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog13 hydrog ? ? B A   11  N1  ? ? ? 1_555 B U  31 N3 ? ? B A   -28 B U  -8  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog14 hydrog ? ? B A   11  N6  ? ? ? 1_555 B U  31 O4 ? ? B A   -28 B U  -8  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog15 hydrog ? ? B A   13  N1  ? ? ? 1_555 B U  30 N3 ? ? B A   -26 B U  -9  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog16 hydrog ? ? B A   13  N6  ? ? ? 1_555 B U  30 O4 ? ? B A   -26 B U  -9  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog17 hydrog ? ? B U   14  N3  ? ? ? 1_555 B A  29 N1 ? ? B U   -25 B A  -10 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog18 hydrog ? ? B U   14  O4  ? ? ? 1_555 B A  29 N6 ? ? B U   -25 B A  -10 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog19 hydrog ? ? B A   15  N1  ? ? ? 1_555 B U  28 N3 ? ? B A   -24 B U  -11 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog20 hydrog ? ? B A   15  N6  ? ? ? 1_555 B U  28 O4 ? ? B A   -24 B U  -11 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog21 hydrog ? ? B U   16  N3  ? ? ? 1_555 B G  27 O6 ? ? B U   -23 B G  -12 1_555 ? ? ? ? ? ? TYPE_28_PAIR ?     ? ? 
hydrog22 hydrog ? ? B U   16  O2  ? ? ? 1_555 B G  27 N1 ? ? B U   -23 B G  -12 1_555 ? ? ? ? ? ? TYPE_28_PAIR ?     ? ? 
hydrog23 hydrog ? ? B C   18  N3  ? ? ? 1_555 B G  26 N1 ? ? B C   -21 B G  -13 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog24 hydrog ? ? B C   18  N4  ? ? ? 1_555 B G  26 O6 ? ? B C   -21 B G  -13 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog25 hydrog ? ? B C   18  O2  ? ? ? 1_555 B G  26 N2 ? ? B C   -21 B G  -13 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog26 hydrog ? ? B U   19  N3  ? ? ? 1_555 B A  25 N1 ? ? B U   -20 B A  -14 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog27 hydrog ? ? B U   19  O4  ? ? ? 1_555 B A  25 N6 ? ? B U   -20 B A  -14 1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog28 hydrog ? ? B G   39  N1  ? ? ? 1_555 D DC 30 N3 ? ? B G   0   D DC 20  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog29 hydrog ? ? B G   39  N2  ? ? ? 1_555 D DC 30 O2 ? ? B G   0   D DC 20  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog30 hydrog ? ? B G   39  O6  ? ? ? 1_555 D DC 30 N4 ? ? B G   0   D DC 20  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog31 hydrog ? ? B G   40  N1  ? ? ? 1_555 D DC 29 N3 ? ? B G   1   D DC 19  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog32 hydrog ? ? B G   40  N2  ? ? ? 1_555 D DC 29 O2 ? ? B G   1   D DC 19  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog33 hydrog ? ? B G   40  O6  ? ? ? 1_555 D DC 29 N4 ? ? B G   1   D DC 19  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog34 hydrog ? ? B A   41  N1  ? ? ? 1_555 D DT 28 N3 ? ? B A   2   D DT 18  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog35 hydrog ? ? B A   41  N6  ? ? ? 1_555 D DT 28 O4 ? ? B A   2   D DT 18  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog36 hydrog ? ? B G   42  N1  ? ? ? 1_555 D DC 27 N3 ? ? B G   3   D DC 17  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog37 hydrog ? ? B G   42  N2  ? ? ? 1_555 D DC 27 O2 ? ? B G   3   D DC 17  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog38 hydrog ? ? B G   42  O6  ? ? ? 1_555 D DC 27 N4 ? ? B G   3   D DC 17  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog39 hydrog ? ? B A   43  N1  ? ? ? 1_555 D DT 26 N3 ? ? B A   4   D DT 16  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog40 hydrog ? ? B A   43  N6  ? ? ? 1_555 D DT 26 O4 ? ? B A   4   D DT 16  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog41 hydrog ? ? B U   44  N3  ? ? ? 1_555 D DA 25 N1 ? ? B U   5   D DA 15  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog42 hydrog ? ? B U   44  O4  ? ? ? 1_555 D DA 25 N6 ? ? B U   5   D DA 15  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog43 hydrog ? ? B G   45  N1  ? ? ? 1_555 D DC 24 N3 ? ? B G   6   D DC 14  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog44 hydrog ? ? B G   45  N2  ? ? ? 1_555 D DC 24 O2 ? ? B G   6   D DC 14  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog45 hydrog ? ? B G   45  O6  ? ? ? 1_555 D DC 24 N4 ? ? B G   6   D DC 14  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog46 hydrog ? ? B A   46  N1  ? ? ? 1_555 D DT 23 N3 ? ? B A   7   D DT 13  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog47 hydrog ? ? B A   46  N6  ? ? ? 1_555 D DT 23 O4 ? ? B A   7   D DT 13  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog48 hydrog ? ? B G   47  N1  ? ? ? 1_555 D DC 22 N3 ? ? B G   8   D DC 12  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog49 hydrog ? ? B G   47  N2  ? ? ? 1_555 D DC 22 O2 ? ? B G   8   D DC 12  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog50 hydrog ? ? B G   47  O6  ? ? ? 1_555 D DC 22 N4 ? ? B G   8   D DC 12  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog51 hydrog ? ? B G   48  N1  ? ? ? 1_555 D DC 21 N3 ? ? B G   9   D DC 11  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog52 hydrog ? ? B G   48  N2  ? ? ? 1_555 D DC 21 O2 ? ? B G   9   D DC 11  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog53 hydrog ? ? B G   48  O6  ? ? ? 1_555 D DC 21 N4 ? ? B G   9   D DC 11  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog54 hydrog ? ? B U   49  N3  ? ? ? 1_555 D DA 20 N1 ? ? B U   10  D DA 10  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog55 hydrog ? ? B U   49  O4  ? ? ? 1_555 D DA 20 N6 ? ? B U   10  D DA 10  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog56 hydrog ? ? B G   50  N1  ? ? ? 1_555 D DC 19 N3 ? ? B G   11  D DC 9   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog57 hydrog ? ? B G   50  N2  ? ? ? 1_555 D DC 19 O2 ? ? B G   11  D DC 9   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog58 hydrog ? ? B G   50  O6  ? ? ? 1_555 D DC 19 N4 ? ? B G   11  D DC 9   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog59 hydrog ? ? B C   51  N3  ? ? ? 1_555 D DG 18 N1 ? ? B C   12  D DG 8   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog60 hydrog ? ? B C   51  N4  ? ? ? 1_555 D DG 18 O6 ? ? B C   12  D DG 8   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog61 hydrog ? ? B C   51  O2  ? ? ? 1_555 D DG 18 N2 ? ? B C   12  D DG 8   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog62 hydrog ? ? B G   52  N1  ? ? ? 1_555 D DC 17 N3 ? ? B G   13  D DC 7   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog63 hydrog ? ? B G   52  N2  ? ? ? 1_555 D DC 17 O2 ? ? B G   13  D DC 7   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog64 hydrog ? ? B G   52  O6  ? ? ? 1_555 D DC 17 N4 ? ? B G   13  D DC 7   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog65 hydrog ? ? B C   53  N3  ? ? ? 1_555 D DG 16 N1 ? ? B C   14  D DG 6   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog66 hydrog ? ? B C   53  N4  ? ? ? 1_555 D DG 16 O6 ? ? B C   14  D DG 6   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog67 hydrog ? ? B C   53  O2  ? ? ? 1_555 D DG 16 N2 ? ? B C   14  D DG 6   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog68 hydrog ? ? B G   54  N1  ? ? ? 1_555 D DC 15 N3 ? ? B G   15  D DC 5   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog69 hydrog ? ? B G   54  N2  ? ? ? 1_555 D DC 15 O2 ? ? B G   15  D DC 5   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog70 hydrog ? ? B G   54  O6  ? ? ? 1_555 D DC 15 N4 ? ? B G   15  D DC 5   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog71 hydrog ? ? B U   55  N3  ? ? ? 1_555 D DA 14 N1 ? ? B U   16  D DA 4   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog72 hydrog ? ? B U   55  O4  ? ? ? 1_555 D DA 14 N6 ? ? B U   16  D DA 4   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog73 hydrog ? ? C DT  1   N3  ? ? ? 1_555 D DA 40 N1 ? ? C DT  -10 D DA 30  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog74 hydrog ? ? C DT  1   O4  ? ? ? 1_555 D DA 40 N6 ? ? C DT  -10 D DA 30  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog75 hydrog ? ? C DG  2   N1  ? ? ? 1_555 D DC 39 N3 ? ? C DG  -9  D DC 29  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog76 hydrog ? ? C DG  2   N2  ? ? ? 1_555 D DC 39 O2 ? ? C DG  -9  D DC 29  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog77 hydrog ? ? C DG  2   O6  ? ? ? 1_555 D DC 39 N4 ? ? C DG  -9  D DC 29  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog78 hydrog ? ? C DT  3   N3  ? ? ? 1_555 D DA 38 N1 ? ? C DT  -8  D DA 28  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog79 hydrog ? ? C DT  3   O4  ? ? ? 1_555 D DA 38 N6 ? ? C DT  -8  D DA 28  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog80 hydrog ? ? C DC  4   N3  ? ? ? 1_555 D DG 37 N1 ? ? C DC  -7  D DG 27  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog81 hydrog ? ? C DC  4   N4  ? ? ? 1_555 D DG 37 O6 ? ? C DC  -7  D DG 27  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog82 hydrog ? ? C DC  4   O2  ? ? ? 1_555 D DG 37 N2 ? ? C DC  -7  D DG 27  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog83 hydrog ? ? C DT  5   N3  ? ? ? 1_555 D DA 36 N1 ? ? C DT  -6  D DA 26  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog84 hydrog ? ? C DT  5   O4  ? ? ? 1_555 D DA 36 N6 ? ? C DT  -6  D DA 26  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog85 hydrog ? ? C DA  6   N1  ? ? ? 1_555 D DT 35 N3 ? ? C DA  -5  D DT 25  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog86 hydrog ? ? C DA  6   N6  ? ? ? 1_555 D DT 35 O4 ? ? C DA  -5  D DT 25  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog87 hydrog ? ? C DT  7   N3  ? ? ? 1_555 D DA 34 N1 ? ? C DT  -4  D DA 24  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog88 hydrog ? ? C DT  7   O4  ? ? ? 1_555 D DA 34 N6 ? ? C DT  -4  D DA 24  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog89 hydrog ? ? C DT  8   N3  ? ? ? 1_555 D DA 33 N1 ? ? C DT  -3  D DA 23  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog90 hydrog ? ? C DT  8   O4  ? ? ? 1_555 D DA 33 N6 ? ? C DT  -3  D DA 23  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog91 hydrog ? ? C DT  9   N3  ? ? ? 1_555 D DA 32 N1 ? ? C DT  -2  D DA 22  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog92 hydrog ? ? C DT  9   O4  ? ? ? 1_555 D DA 32 N6 ? ? C DT  -2  D DA 22  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog93 hydrog ? ? C DA  10  N1  ? ? ? 1_555 D DT 31 N3 ? ? C DA  -1  D DT 21  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog94 hydrog ? ? C DA  10  N6  ? ? ? 1_555 D DT 31 O4 ? ? C DA  -1  D DT 21  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
metalc ? ? 
hydrog ? ? 
# 
_pdbx_struct_conn_angle.id                    1 
_pdbx_struct_conn_angle.ptnr1_label_atom_id   OD1 
_pdbx_struct_conn_angle.ptnr1_label_alt_id    ? 
_pdbx_struct_conn_angle.ptnr1_label_asym_id   A 
_pdbx_struct_conn_angle.ptnr1_label_comp_id   ASP 
_pdbx_struct_conn_angle.ptnr1_label_seq_id    509 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id    ? 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id    A 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id    ASP 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id     499 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code    ? 
_pdbx_struct_conn_angle.ptnr1_symmetry        1_555 
_pdbx_struct_conn_angle.ptnr2_label_atom_id   MG 
_pdbx_struct_conn_angle.ptnr2_label_alt_id    ? 
_pdbx_struct_conn_angle.ptnr2_label_asym_id   E 
_pdbx_struct_conn_angle.ptnr2_label_comp_id   MG 
_pdbx_struct_conn_angle.ptnr2_label_seq_id    . 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id    ? 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id    A 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id    MG 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id     801 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code    ? 
_pdbx_struct_conn_angle.ptnr2_symmetry        1_555 
_pdbx_struct_conn_angle.ptnr3_label_atom_id   OP1 
_pdbx_struct_conn_angle.ptnr3_label_alt_id    ? 
_pdbx_struct_conn_angle.ptnr3_label_asym_id   B 
_pdbx_struct_conn_angle.ptnr3_label_comp_id   G 
_pdbx_struct_conn_angle.ptnr3_label_seq_id    9 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id    ? 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id    B 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id    G 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id     -30 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code    ? 
_pdbx_struct_conn_angle.ptnr3_symmetry        1_555 
_pdbx_struct_conn_angle.value                 85.1 
_pdbx_struct_conn_angle.value_esd             ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 3 ? 
AA3 ? 4 ? 
AA4 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? parallel      
AA4 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 LYS A 12  ? LYS A 18  ? LYS A 2   LYS A 8   
AA1 2 LEU A 310 ? GLU A 317 ? LEU A 300 GLU A 307 
AA1 3 ASN A 300 ? ILE A 305 ? ASN A 290 ILE A 295 
AA1 4 SER A 243 ? ILE A 247 ? SER A 233 ILE A 237 
AA2 1 LYS A 252 ? GLU A 255 ? LYS A 242 GLU A 245 
AA2 2 PHE A 262 ? LEU A 268 ? PHE A 252 LEU A 258 
AA2 3 LYS A 271 ? LEU A 277 ? LYS A 261 LEU A 267 
AA3 1 VAL A 386 ? PHE A 389 ? VAL A 376 PHE A 379 
AA3 2 PHE A 342 ? LYS A 347 ? PHE A 332 LYS A 337 
AA3 3 LYS A 329 ? VAL A 335 ? LYS A 319 VAL A 325 
AA3 4 TYR A 530 ? GLU A 536 ? TYR A 520 GLU A 526 
AA4 1 TYR A 584 ? ILE A 587 ? TYR A 574 ILE A 577 
AA4 2 ASP A 596 ? TYR A 599 ? ASP A 586 TYR A 589 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N PHE A 17  ? N PHE A 7   O VAL A 312 ? O VAL A 302 
AA1 2 3 O TYR A 311 ? O TYR A 301 N ILE A 304 ? N ILE A 294 
AA1 3 4 O ILE A 301 ? O ILE A 291 N LEU A 246 ? N LEU A 236 
AA2 1 2 N GLU A 254 ? N GLU A 244 O ILE A 263 ? O ILE A 253 
AA2 2 3 N LEU A 264 ? N LEU A 254 O ILE A 275 ? O ILE A 265 
AA3 1 2 O VAL A 387 ? O VAL A 377 N THR A 344 ? N THR A 334 
AA3 2 3 O VAL A 343 ? O VAL A 333 N ASP A 334 ? N ASP A 324 
AA3 3 4 N VAL A 331 ? N VAL A 321 O ALA A 534 ? O ALA A 524 
AA4 1 2 N ILE A 587 ? N ILE A 577 O ASP A 596 ? O ASP A 586 
# 
_pdbx_entry_details.entry_id                   9IZP 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 TYR A 103 ? ? -58.53  109.93  
2 1 ARG A 116 ? ? -102.18 -61.01  
3 1 ARG A 271 ? ? -66.47  1.99    
4 1 VAL A 318 ? ? -120.18 -60.57  
5 1 CYS A 380 ? ? 59.73   75.73   
6 1 PRO A 381 ? ? -68.85  57.16   
7 1 LEU A 551 ? ? -92.89  52.00   
8 1 ASN A 579 ? ? -128.87 -167.05 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9IZP 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    9IZP 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  2.89 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               149163 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.6 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'CasLambda2-crRNA-target DNA ternary complex' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       '1, 2, 3, 4' 
# 
_em_imaging.entry_id                        9IZP 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'TFS KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               OTHER 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             800 
_em_imaging.nominal_defocus_max             1600 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              9IZP 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9IZP 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A MET -9  ? A MET 1   
2   1 Y 1 A GLY -8  ? A GLY 2   
3   1 Y 1 A HIS -7  ? A HIS 3   
4   1 Y 1 A HIS -6  ? A HIS 4   
5   1 Y 1 A HIS -5  ? A HIS 5   
6   1 Y 1 A HIS -4  ? A HIS 6   
7   1 Y 1 A HIS -3  ? A HIS 7   
8   1 Y 1 A HIS -2  ? A HIS 8   
9   1 Y 1 A GLY -1  ? A GLY 9   
10  1 Y 1 A GLY 0   ? A GLY 10  
11  1 Y 1 A LEU 528 ? A LEU 538 
12  1 Y 1 A GLU 529 ? A GLU 539 
13  1 Y 1 A ASN 530 ? A ASN 540 
14  1 Y 1 A SER 531 ? A SER 541 
15  1 Y 1 A ASN 532 ? A ASN 542 
16  1 Y 1 A PRO 634 ? A PRO 644 
17  1 Y 1 A SER 635 ? A SER 645 
18  1 Y 1 A GLU 636 ? A GLU 646 
19  1 Y 1 A PHE 637 ? A PHE 647 
20  1 Y 1 A THR 638 ? A THR 648 
21  1 Y 1 A SER 639 ? A SER 649 
22  1 Y 1 A GLN 640 ? A GLN 650 
23  1 Y 1 A MET 641 ? A MET 651 
24  1 Y 1 A ASP 642 ? A ASP 652 
25  1 Y 1 A SER 643 ? A SER 653 
26  1 Y 1 A THR 644 ? A THR 654 
27  1 Y 1 A ASP 645 ? A ASP 655 
28  1 Y 1 A HIS 646 ? A HIS 656 
29  1 Y 1 A CYS 647 ? A CYS 657 
30  1 Y 1 A LEU 648 ? A LEU 658 
31  1 Y 1 A TYR 649 ? A TYR 659 
32  1 Y 1 A MET 650 ? A MET 660 
33  1 Y 1 A LYS 651 ? A LYS 661 
34  1 Y 1 A LYS 652 ? A LYS 662 
35  1 Y 1 A ASN 653 ? A ASN 663 
36  1 Y 1 A ASP 654 ? A ASP 664 
37  1 Y 1 A LYS 655 ? A LYS 665 
38  1 Y 1 A GLY 656 ? A GLY 666 
39  1 Y 1 A LYS 657 ? A LYS 667 
40  1 Y 1 A LEU 658 ? A LEU 668 
41  1 Y 1 A VAL 659 ? A VAL 669 
42  1 Y 1 A LYS 660 ? A LYS 670 
43  1 Y 1 A ALA 661 ? A ALA 671 
44  1 Y 1 A ASP 662 ? A ASP 672 
45  1 Y 1 A LYS 663 ? A LYS 673 
46  1 Y 1 A LYS 664 ? A LYS 674 
47  1 Y 1 A GLU 665 ? A GLU 675 
48  1 Y 1 A VAL 666 ? A VAL 676 
49  1 Y 1 A ARG 667 ? A ARG 677 
50  1 Y 1 A THR 668 ? A THR 678 
51  1 Y 1 A LYS 669 ? A LYS 679 
52  1 Y 1 A GLN 670 ? A GLN 680 
53  1 Y 1 A GLU 671 ? A GLU 681 
54  1 Y 1 A LYS 672 ? A LYS 682 
55  1 Y 1 A HIS 673 ? A HIS 683 
56  1 Y 1 A ILE 674 ? A ILE 684 
57  1 Y 1 A ASN 675 ? A ASN 685 
58  1 Y 1 A GLY 676 ? A GLY 686 
59  1 Y 1 A LEU 677 ? A LEU 687 
60  1 Y 1 A ASN 678 ? A ASN 688 
61  1 Y 1 A ALA 679 ? A ALA 689 
62  1 Y 1 A ASP 680 ? A ASP 690 
63  1 Y 1 A PHE 681 ? A PHE 691 
64  1 Y 1 A ASN 682 ? A ASN 692 
65  1 Y 1 A ALA 683 ? A ALA 693 
66  1 Y 1 A ALA 684 ? A ALA 694 
67  1 Y 1 A ASN 685 ? A ASN 695 
68  1 Y 1 A ASN 686 ? A ASN 696 
69  1 Y 1 A ILE 687 ? A ILE 697 
70  1 Y 1 A LYS 688 ? A LYS 698 
71  1 Y 1 A TYR 689 ? A TYR 699 
72  1 Y 1 A ILE 690 ? A ILE 700 
73  1 Y 1 A VAL 691 ? A VAL 701 
74  1 Y 1 A GLU 692 ? A GLU 702 
75  1 Y 1 A ASN 693 ? A ASN 703 
76  1 Y 1 A GLU 694 ? A GLU 704 
77  1 Y 1 A VAL 695 ? A VAL 705 
78  1 Y 1 A TRP 696 ? A TRP 706 
79  1 Y 1 A ARG 697 ? A ARG 707 
80  1 Y 1 A GLU 698 ? A GLU 708 
81  1 Y 1 A ILE 699 ? A ILE 709 
82  1 Y 1 A PHE 700 ? A PHE 710 
83  1 Y 1 A CYS 701 ? A CYS 711 
84  1 Y 1 A THR 702 ? A THR 712 
85  1 Y 1 A ARG 703 ? A ARG 713 
86  1 Y 1 A PRO 704 ? A PRO 714 
87  1 Y 1 A LYS 705 ? A LYS 715 
88  1 Y 1 A LYS 706 ? A LYS 716 
89  1 Y 1 A ALA 707 ? A ALA 717 
90  1 Y 1 A GLU 708 ? A GLU 718 
91  1 Y 1 A TYR 709 ? A TYR 719 
92  1 Y 1 A ASN 710 ? A ASN 720 
93  1 Y 1 A VAL 711 ? A VAL 721 
94  1 Y 1 A PRO 712 ? A PRO 722 
95  1 Y 1 A SER 713 ? A SER 723 
96  1 Y 1 A LEU 714 ? A LEU 724 
97  1 Y 1 A ASP 715 ? A ASP 725 
98  1 Y 1 A THR 716 ? A THR 726 
99  1 Y 1 A THR 717 ? A THR 727 
100 1 Y 1 A LYS 718 ? A LYS 728 
101 1 Y 1 A LYS 719 ? A LYS 729 
102 1 Y 1 A GLY 720 ? A GLY 730 
103 1 Y 1 A PRO 721 ? A PRO 731 
104 1 Y 1 A SER 722 ? A SER 732 
105 1 Y 1 A ALA 723 ? A ALA 733 
106 1 Y 1 A ILE 724 ? A ILE 734 
107 1 Y 1 A LEU 725 ? A LEU 735 
108 1 Y 1 A HIS 726 ? A HIS 736 
109 1 Y 1 A MET 727 ? A MET 737 
110 1 Y 1 A LEU 728 ? A LEU 738 
111 1 Y 1 A LYS 729 ? A LYS 739 
112 1 Y 1 A LYS 730 ? A LYS 740 
113 1 Y 1 A ILE 731 ? A ILE 741 
114 1 Y 1 A GLU 732 ? A GLU 742 
115 1 Y 1 A ALA 733 ? A ALA 743 
116 1 Y 1 A ILE 734 ? A ILE 744 
117 1 Y 1 A LYS 735 ? A LYS 745 
118 1 Y 1 A ILE 736 ? A ILE 746 
119 1 Y 1 A LEU 737 ? A LEU 747 
120 1 Y 1 A GLU 738 ? A GLU 748 
121 1 Y 1 A THR 739 ? A THR 749 
122 1 Y 1 A GLU 740 ? A GLU 750 
123 1 Y 1 A LYS 741 ? A LYS 751 
124 1 Y 1 B G   -38 ? B G   1   
125 1 Y 1 B G   -37 ? B G   2   
126 1 Y 1 B G   17  ? B G   56  
127 1 Y 1 B G   18  ? B G   57  
128 1 Y 1 B C   19  ? B C   58  
129 1 Y 1 C DG  3   ? C DG  14  
130 1 Y 1 C DA  4   ? C DA  15  
131 1 Y 1 C DT  5   ? C DT  16  
132 1 Y 1 C DG  6   ? C DG  17  
133 1 Y 1 C DA  7   ? C DA  18  
134 1 Y 1 C DG  8   ? C DG  19  
135 1 Y 1 C DG  9   ? C DG  20  
136 1 Y 1 C DT  10  ? C DT  21  
137 1 Y 1 C DG  11  ? C DG  22  
138 1 Y 1 C DC  12  ? C DC  23  
139 1 Y 1 C DG  13  ? C DG  24  
140 1 Y 1 C DC  14  ? C DC  25  
141 1 Y 1 C DG  15  ? C DG  26  
142 1 Y 1 C DT  16  ? C DT  27  
143 1 Y 1 C DG  17  ? C DG  28  
144 1 Y 1 C GS  18  ? C GS  29  
145 1 Y 1 C SC  19  ? C SC  30  
146 1 Y 1 C AS  20  ? C AS  31  
147 1 Y 1 C SC  21  ? C SC  32  
148 1 Y 1 C SC  22  ? C SC  33  
149 1 Y 1 C AS  23  ? C AS  34  
150 1 Y 1 C PST 24  ? C PST 35  
151 1 Y 1 C SC  25  ? C SC  36  
152 1 Y 1 C AS  26  ? C AS  37  
153 1 Y 1 C PST 27  ? C PST 38  
154 1 Y 1 C AS  28  ? C AS  39  
155 1 Y 1 C PST 29  ? C PST 40  
156 1 Y 1 D AS  -9  ? D AS  1   
157 1 Y 1 D PST -8  ? D PST 2   
158 1 Y 1 D AS  -7  ? D AS  3   
159 1 Y 1 D PST -6  ? D PST 4   
160 1 Y 1 D GS  -5  ? D GS  5   
161 1 Y 1 D AS  -4  ? D AS  6   
162 1 Y 1 D PST -3  ? D PST 7   
163 1 Y 1 D GS  -2  ? D GS  8   
164 1 Y 1 D GS  -1  ? D GS  9   
165 1 Y 1 D PST 0   ? D PST 10  
166 1 Y 1 D GS  1   ? D GS  11  
167 1 Y 1 D SC  2   ? D SC  12  
168 1 Y 1 D DC  3   ? D DC  13  
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A   OP3    O  N N 1   
A   P      P  N N 2   
A   OP1    O  N N 3   
A   OP2    O  N N 4   
A   "O5'"  O  N N 5   
A   "C5'"  C  N N 6   
A   "C4'"  C  N R 7   
A   "O4'"  O  N N 8   
A   "C3'"  C  N S 9   
A   "O3'"  O  N N 10  
A   "C2'"  C  N R 11  
A   "O2'"  O  N N 12  
A   "C1'"  C  N R 13  
A   N9     N  Y N 14  
A   C8     C  Y N 15  
A   N7     N  Y N 16  
A   C5     C  Y N 17  
A   C6     C  Y N 18  
A   N6     N  N N 19  
A   N1     N  Y N 20  
A   C2     C  Y N 21  
A   N3     N  Y N 22  
A   C4     C  Y N 23  
A   HOP3   H  N N 24  
A   HOP2   H  N N 25  
A   "H5'"  H  N N 26  
A   "H5''" H  N N 27  
A   "H4'"  H  N N 28  
A   "H3'"  H  N N 29  
A   "HO3'" H  N N 30  
A   "H2'"  H  N N 31  
A   "HO2'" H  N N 32  
A   "H1'"  H  N N 33  
A   H8     H  N N 34  
A   H61    H  N N 35  
A   H62    H  N N 36  
A   H2     H  N N 37  
ALA N      N  N N 38  
ALA CA     C  N S 39  
ALA C      C  N N 40  
ALA O      O  N N 41  
ALA CB     C  N N 42  
ALA OXT    O  N N 43  
ALA H      H  N N 44  
ALA H2     H  N N 45  
ALA HA     H  N N 46  
ALA HB1    H  N N 47  
ALA HB2    H  N N 48  
ALA HB3    H  N N 49  
ALA HXT    H  N N 50  
ARG N      N  N N 51  
ARG CA     C  N S 52  
ARG C      C  N N 53  
ARG O      O  N N 54  
ARG CB     C  N N 55  
ARG CG     C  N N 56  
ARG CD     C  N N 57  
ARG NE     N  N N 58  
ARG CZ     C  N N 59  
ARG NH1    N  N N 60  
ARG NH2    N  N N 61  
ARG OXT    O  N N 62  
ARG H      H  N N 63  
ARG H2     H  N N 64  
ARG HA     H  N N 65  
ARG HB2    H  N N 66  
ARG HB3    H  N N 67  
ARG HG2    H  N N 68  
ARG HG3    H  N N 69  
ARG HD2    H  N N 70  
ARG HD3    H  N N 71  
ARG HE     H  N N 72  
ARG HH11   H  N N 73  
ARG HH12   H  N N 74  
ARG HH21   H  N N 75  
ARG HH22   H  N N 76  
ARG HXT    H  N N 77  
AS  P      P  N N 78  
AS  OP1    O  N N 79  
AS  S2P    S  N N 80  
AS  OP3    O  N N 81  
AS  "O5'"  O  N N 82  
AS  "C5'"  C  N N 83  
AS  "C4'"  C  N R 84  
AS  "O4'"  O  N N 85  
AS  "C3'"  C  N S 86  
AS  "O3'"  O  N N 87  
AS  "C2'"  C  N N 88  
AS  "C1'"  C  N R 89  
AS  N9     N  Y N 90  
AS  C8     C  Y N 91  
AS  N7     N  Y N 92  
AS  C5     C  Y N 93  
AS  C6     C  Y N 94  
AS  N6     N  N N 95  
AS  N1     N  Y N 96  
AS  C2     C  Y N 97  
AS  N3     N  Y N 98  
AS  C4     C  Y N 99  
AS  HOP1   H  N N 100 
AS  HOP3   H  N N 101 
AS  "H5'"  H  N N 102 
AS  "H5''" H  N N 103 
AS  "H4'"  H  N N 104 
AS  "H3'"  H  N N 105 
AS  "HO3'" H  N N 106 
AS  "H2'"  H  N N 107 
AS  "H2''" H  N N 108 
AS  "H1'"  H  N N 109 
AS  H8     H  N N 110 
AS  HN61   H  N N 111 
AS  HN62   H  N N 112 
AS  H2     H  N N 113 
ASN N      N  N N 114 
ASN CA     C  N S 115 
ASN C      C  N N 116 
ASN O      O  N N 117 
ASN CB     C  N N 118 
ASN CG     C  N N 119 
ASN OD1    O  N N 120 
ASN ND2    N  N N 121 
ASN OXT    O  N N 122 
ASN H      H  N N 123 
ASN H2     H  N N 124 
ASN HA     H  N N 125 
ASN HB2    H  N N 126 
ASN HB3    H  N N 127 
ASN HD21   H  N N 128 
ASN HD22   H  N N 129 
ASN HXT    H  N N 130 
ASP N      N  N N 131 
ASP CA     C  N S 132 
ASP C      C  N N 133 
ASP O      O  N N 134 
ASP CB     C  N N 135 
ASP CG     C  N N 136 
ASP OD1    O  N N 137 
ASP OD2    O  N N 138 
ASP OXT    O  N N 139 
ASP H      H  N N 140 
ASP H2     H  N N 141 
ASP HA     H  N N 142 
ASP HB2    H  N N 143 
ASP HB3    H  N N 144 
ASP HD2    H  N N 145 
ASP HXT    H  N N 146 
C   OP3    O  N N 147 
C   P      P  N N 148 
C   OP1    O  N N 149 
C   OP2    O  N N 150 
C   "O5'"  O  N N 151 
C   "C5'"  C  N N 152 
C   "C4'"  C  N R 153 
C   "O4'"  O  N N 154 
C   "C3'"  C  N S 155 
C   "O3'"  O  N N 156 
C   "C2'"  C  N R 157 
C   "O2'"  O  N N 158 
C   "C1'"  C  N R 159 
C   N1     N  N N 160 
C   C2     C  N N 161 
C   O2     O  N N 162 
C   N3     N  N N 163 
C   C4     C  N N 164 
C   N4     N  N N 165 
C   C5     C  N N 166 
C   C6     C  N N 167 
C   HOP3   H  N N 168 
C   HOP2   H  N N 169 
C   "H5'"  H  N N 170 
C   "H5''" H  N N 171 
C   "H4'"  H  N N 172 
C   "H3'"  H  N N 173 
C   "HO3'" H  N N 174 
C   "H2'"  H  N N 175 
C   "HO2'" H  N N 176 
C   "H1'"  H  N N 177 
C   H41    H  N N 178 
C   H42    H  N N 179 
C   H5     H  N N 180 
C   H6     H  N N 181 
CYS N      N  N N 182 
CYS CA     C  N R 183 
CYS C      C  N N 184 
CYS O      O  N N 185 
CYS CB     C  N N 186 
CYS SG     S  N N 187 
CYS OXT    O  N N 188 
CYS H      H  N N 189 
CYS H2     H  N N 190 
CYS HA     H  N N 191 
CYS HB2    H  N N 192 
CYS HB3    H  N N 193 
CYS HG     H  N N 194 
CYS HXT    H  N N 195 
DA  OP3    O  N N 196 
DA  P      P  N N 197 
DA  OP1    O  N N 198 
DA  OP2    O  N N 199 
DA  "O5'"  O  N N 200 
DA  "C5'"  C  N N 201 
DA  "C4'"  C  N R 202 
DA  "O4'"  O  N N 203 
DA  "C3'"  C  N S 204 
DA  "O3'"  O  N N 205 
DA  "C2'"  C  N N 206 
DA  "C1'"  C  N R 207 
DA  N9     N  Y N 208 
DA  C8     C  Y N 209 
DA  N7     N  Y N 210 
DA  C5     C  Y N 211 
DA  C6     C  Y N 212 
DA  N6     N  N N 213 
DA  N1     N  Y N 214 
DA  C2     C  Y N 215 
DA  N3     N  Y N 216 
DA  C4     C  Y N 217 
DA  HOP3   H  N N 218 
DA  HOP2   H  N N 219 
DA  "H5'"  H  N N 220 
DA  "H5''" H  N N 221 
DA  "H4'"  H  N N 222 
DA  "H3'"  H  N N 223 
DA  "HO3'" H  N N 224 
DA  "H2'"  H  N N 225 
DA  "H2''" H  N N 226 
DA  "H1'"  H  N N 227 
DA  H8     H  N N 228 
DA  H61    H  N N 229 
DA  H62    H  N N 230 
DA  H2     H  N N 231 
DC  OP3    O  N N 232 
DC  P      P  N N 233 
DC  OP1    O  N N 234 
DC  OP2    O  N N 235 
DC  "O5'"  O  N N 236 
DC  "C5'"  C  N N 237 
DC  "C4'"  C  N R 238 
DC  "O4'"  O  N N 239 
DC  "C3'"  C  N S 240 
DC  "O3'"  O  N N 241 
DC  "C2'"  C  N N 242 
DC  "C1'"  C  N R 243 
DC  N1     N  N N 244 
DC  C2     C  N N 245 
DC  O2     O  N N 246 
DC  N3     N  N N 247 
DC  C4     C  N N 248 
DC  N4     N  N N 249 
DC  C5     C  N N 250 
DC  C6     C  N N 251 
DC  HOP3   H  N N 252 
DC  HOP2   H  N N 253 
DC  "H5'"  H  N N 254 
DC  "H5''" H  N N 255 
DC  "H4'"  H  N N 256 
DC  "H3'"  H  N N 257 
DC  "HO3'" H  N N 258 
DC  "H2'"  H  N N 259 
DC  "H2''" H  N N 260 
DC  "H1'"  H  N N 261 
DC  H41    H  N N 262 
DC  H42    H  N N 263 
DC  H5     H  N N 264 
DC  H6     H  N N 265 
DG  OP3    O  N N 266 
DG  P      P  N N 267 
DG  OP1    O  N N 268 
DG  OP2    O  N N 269 
DG  "O5'"  O  N N 270 
DG  "C5'"  C  N N 271 
DG  "C4'"  C  N R 272 
DG  "O4'"  O  N N 273 
DG  "C3'"  C  N S 274 
DG  "O3'"  O  N N 275 
DG  "C2'"  C  N N 276 
DG  "C1'"  C  N R 277 
DG  N9     N  Y N 278 
DG  C8     C  Y N 279 
DG  N7     N  Y N 280 
DG  C5     C  Y N 281 
DG  C6     C  N N 282 
DG  O6     O  N N 283 
DG  N1     N  N N 284 
DG  C2     C  N N 285 
DG  N2     N  N N 286 
DG  N3     N  N N 287 
DG  C4     C  Y N 288 
DG  HOP3   H  N N 289 
DG  HOP2   H  N N 290 
DG  "H5'"  H  N N 291 
DG  "H5''" H  N N 292 
DG  "H4'"  H  N N 293 
DG  "H3'"  H  N N 294 
DG  "HO3'" H  N N 295 
DG  "H2'"  H  N N 296 
DG  "H2''" H  N N 297 
DG  "H1'"  H  N N 298 
DG  H8     H  N N 299 
DG  H1     H  N N 300 
DG  H21    H  N N 301 
DG  H22    H  N N 302 
DT  OP3    O  N N 303 
DT  P      P  N N 304 
DT  OP1    O  N N 305 
DT  OP2    O  N N 306 
DT  "O5'"  O  N N 307 
DT  "C5'"  C  N N 308 
DT  "C4'"  C  N R 309 
DT  "O4'"  O  N N 310 
DT  "C3'"  C  N S 311 
DT  "O3'"  O  N N 312 
DT  "C2'"  C  N N 313 
DT  "C1'"  C  N R 314 
DT  N1     N  N N 315 
DT  C2     C  N N 316 
DT  O2     O  N N 317 
DT  N3     N  N N 318 
DT  C4     C  N N 319 
DT  O4     O  N N 320 
DT  C5     C  N N 321 
DT  C7     C  N N 322 
DT  C6     C  N N 323 
DT  HOP3   H  N N 324 
DT  HOP2   H  N N 325 
DT  "H5'"  H  N N 326 
DT  "H5''" H  N N 327 
DT  "H4'"  H  N N 328 
DT  "H3'"  H  N N 329 
DT  "HO3'" H  N N 330 
DT  "H2'"  H  N N 331 
DT  "H2''" H  N N 332 
DT  "H1'"  H  N N 333 
DT  H3     H  N N 334 
DT  H71    H  N N 335 
DT  H72    H  N N 336 
DT  H73    H  N N 337 
DT  H6     H  N N 338 
G   OP3    O  N N 339 
G   P      P  N N 340 
G   OP1    O  N N 341 
G   OP2    O  N N 342 
G   "O5'"  O  N N 343 
G   "C5'"  C  N N 344 
G   "C4'"  C  N R 345 
G   "O4'"  O  N N 346 
G   "C3'"  C  N S 347 
G   "O3'"  O  N N 348 
G   "C2'"  C  N R 349 
G   "O2'"  O  N N 350 
G   "C1'"  C  N R 351 
G   N9     N  Y N 352 
G   C8     C  Y N 353 
G   N7     N  Y N 354 
G   C5     C  Y N 355 
G   C6     C  N N 356 
G   O6     O  N N 357 
G   N1     N  N N 358 
G   C2     C  N N 359 
G   N2     N  N N 360 
G   N3     N  N N 361 
G   C4     C  Y N 362 
G   HOP3   H  N N 363 
G   HOP2   H  N N 364 
G   "H5'"  H  N N 365 
G   "H5''" H  N N 366 
G   "H4'"  H  N N 367 
G   "H3'"  H  N N 368 
G   "HO3'" H  N N 369 
G   "H2'"  H  N N 370 
G   "HO2'" H  N N 371 
G   "H1'"  H  N N 372 
G   H8     H  N N 373 
G   H1     H  N N 374 
G   H21    H  N N 375 
G   H22    H  N N 376 
GLN N      N  N N 377 
GLN CA     C  N S 378 
GLN C      C  N N 379 
GLN O      O  N N 380 
GLN CB     C  N N 381 
GLN CG     C  N N 382 
GLN CD     C  N N 383 
GLN OE1    O  N N 384 
GLN NE2    N  N N 385 
GLN OXT    O  N N 386 
GLN H      H  N N 387 
GLN H2     H  N N 388 
GLN HA     H  N N 389 
GLN HB2    H  N N 390 
GLN HB3    H  N N 391 
GLN HG2    H  N N 392 
GLN HG3    H  N N 393 
GLN HE21   H  N N 394 
GLN HE22   H  N N 395 
GLN HXT    H  N N 396 
GLU N      N  N N 397 
GLU CA     C  N S 398 
GLU C      C  N N 399 
GLU O      O  N N 400 
GLU CB     C  N N 401 
GLU CG     C  N N 402 
GLU CD     C  N N 403 
GLU OE1    O  N N 404 
GLU OE2    O  N N 405 
GLU OXT    O  N N 406 
GLU H      H  N N 407 
GLU H2     H  N N 408 
GLU HA     H  N N 409 
GLU HB2    H  N N 410 
GLU HB3    H  N N 411 
GLU HG2    H  N N 412 
GLU HG3    H  N N 413 
GLU HE2    H  N N 414 
GLU HXT    H  N N 415 
GLY N      N  N N 416 
GLY CA     C  N N 417 
GLY C      C  N N 418 
GLY O      O  N N 419 
GLY OXT    O  N N 420 
GLY H      H  N N 421 
GLY H2     H  N N 422 
GLY HA2    H  N N 423 
GLY HA3    H  N N 424 
GLY HXT    H  N N 425 
GS  P      P  N S 426 
GS  OP1    O  N N 427 
GS  S2P    S  N N 428 
GS  OP3    O  N N 429 
GS  "O5'"  O  N N 430 
GS  "C5'"  C  N N 431 
GS  "C4'"  C  N R 432 
GS  "O4'"  O  N N 433 
GS  "C3'"  C  N S 434 
GS  "O3'"  O  N N 435 
GS  "C2'"  C  N N 436 
GS  "C1'"  C  N R 437 
GS  N9     N  Y N 438 
GS  C8     C  Y N 439 
GS  N7     N  Y N 440 
GS  C5     C  Y N 441 
GS  C6     C  N N 442 
GS  O6     O  N N 443 
GS  N1     N  N N 444 
GS  C2     C  N N 445 
GS  N2     N  N N 446 
GS  N3     N  N N 447 
GS  C4     C  Y N 448 
GS  HSP2   H  N N 449 
GS  HOP3   H  N N 450 
GS  "H5'"  H  N N 451 
GS  "H5''" H  N N 452 
GS  "H4'"  H  N N 453 
GS  "H3'"  H  N N 454 
GS  "HO3'" H  N N 455 
GS  "H2'"  H  N N 456 
GS  "H2''" H  N N 457 
GS  "H1'"  H  N N 458 
GS  H8     H  N N 459 
GS  HN1    H  N N 460 
GS  HN21   H  N N 461 
GS  HN22   H  N N 462 
HIS N      N  N N 463 
HIS CA     C  N S 464 
HIS C      C  N N 465 
HIS O      O  N N 466 
HIS CB     C  N N 467 
HIS CG     C  Y N 468 
HIS ND1    N  Y N 469 
HIS CD2    C  Y N 470 
HIS CE1    C  Y N 471 
HIS NE2    N  Y N 472 
HIS OXT    O  N N 473 
HIS H      H  N N 474 
HIS H2     H  N N 475 
HIS HA     H  N N 476 
HIS HB2    H  N N 477 
HIS HB3    H  N N 478 
HIS HD1    H  N N 479 
HIS HD2    H  N N 480 
HIS HE1    H  N N 481 
HIS HE2    H  N N 482 
HIS HXT    H  N N 483 
ILE N      N  N N 484 
ILE CA     C  N S 485 
ILE C      C  N N 486 
ILE O      O  N N 487 
ILE CB     C  N S 488 
ILE CG1    C  N N 489 
ILE CG2    C  N N 490 
ILE CD1    C  N N 491 
ILE OXT    O  N N 492 
ILE H      H  N N 493 
ILE H2     H  N N 494 
ILE HA     H  N N 495 
ILE HB     H  N N 496 
ILE HG12   H  N N 497 
ILE HG13   H  N N 498 
ILE HG21   H  N N 499 
ILE HG22   H  N N 500 
ILE HG23   H  N N 501 
ILE HD11   H  N N 502 
ILE HD12   H  N N 503 
ILE HD13   H  N N 504 
ILE HXT    H  N N 505 
LEU N      N  N N 506 
LEU CA     C  N S 507 
LEU C      C  N N 508 
LEU O      O  N N 509 
LEU CB     C  N N 510 
LEU CG     C  N N 511 
LEU CD1    C  N N 512 
LEU CD2    C  N N 513 
LEU OXT    O  N N 514 
LEU H      H  N N 515 
LEU H2     H  N N 516 
LEU HA     H  N N 517 
LEU HB2    H  N N 518 
LEU HB3    H  N N 519 
LEU HG     H  N N 520 
LEU HD11   H  N N 521 
LEU HD12   H  N N 522 
LEU HD13   H  N N 523 
LEU HD21   H  N N 524 
LEU HD22   H  N N 525 
LEU HD23   H  N N 526 
LEU HXT    H  N N 527 
LYS N      N  N N 528 
LYS CA     C  N S 529 
LYS C      C  N N 530 
LYS O      O  N N 531 
LYS CB     C  N N 532 
LYS CG     C  N N 533 
LYS CD     C  N N 534 
LYS CE     C  N N 535 
LYS NZ     N  N N 536 
LYS OXT    O  N N 537 
LYS H      H  N N 538 
LYS H2     H  N N 539 
LYS HA     H  N N 540 
LYS HB2    H  N N 541 
LYS HB3    H  N N 542 
LYS HG2    H  N N 543 
LYS HG3    H  N N 544 
LYS HD2    H  N N 545 
LYS HD3    H  N N 546 
LYS HE2    H  N N 547 
LYS HE3    H  N N 548 
LYS HZ1    H  N N 549 
LYS HZ2    H  N N 550 
LYS HZ3    H  N N 551 
LYS HXT    H  N N 552 
MET N      N  N N 553 
MET CA     C  N S 554 
MET C      C  N N 555 
MET O      O  N N 556 
MET CB     C  N N 557 
MET CG     C  N N 558 
MET SD     S  N N 559 
MET CE     C  N N 560 
MET OXT    O  N N 561 
MET H      H  N N 562 
MET H2     H  N N 563 
MET HA     H  N N 564 
MET HB2    H  N N 565 
MET HB3    H  N N 566 
MET HG2    H  N N 567 
MET HG3    H  N N 568 
MET HE1    H  N N 569 
MET HE2    H  N N 570 
MET HE3    H  N N 571 
MET HXT    H  N N 572 
MG  MG     MG N N 573 
PHE N      N  N N 574 
PHE CA     C  N S 575 
PHE C      C  N N 576 
PHE O      O  N N 577 
PHE CB     C  N N 578 
PHE CG     C  Y N 579 
PHE CD1    C  Y N 580 
PHE CD2    C  Y N 581 
PHE CE1    C  Y N 582 
PHE CE2    C  Y N 583 
PHE CZ     C  Y N 584 
PHE OXT    O  N N 585 
PHE H      H  N N 586 
PHE H2     H  N N 587 
PHE HA     H  N N 588 
PHE HB2    H  N N 589 
PHE HB3    H  N N 590 
PHE HD1    H  N N 591 
PHE HD2    H  N N 592 
PHE HE1    H  N N 593 
PHE HE2    H  N N 594 
PHE HZ     H  N N 595 
PHE HXT    H  N N 596 
PRO N      N  N N 597 
PRO CA     C  N S 598 
PRO C      C  N N 599 
PRO O      O  N N 600 
PRO CB     C  N N 601 
PRO CG     C  N N 602 
PRO CD     C  N N 603 
PRO OXT    O  N N 604 
PRO H      H  N N 605 
PRO HA     H  N N 606 
PRO HB2    H  N N 607 
PRO HB3    H  N N 608 
PRO HG2    H  N N 609 
PRO HG3    H  N N 610 
PRO HD2    H  N N 611 
PRO HD3    H  N N 612 
PRO HXT    H  N N 613 
PST P      P  N N 614 
PST OP1    O  N N 615 
PST OP2    O  N N 616 
PST SP     S  N N 617 
PST "O5'"  O  N N 618 
PST "C5'"  C  N N 619 
PST "C4'"  C  N R 620 
PST "O4'"  O  N N 621 
PST "C3'"  C  N S 622 
PST "O3'"  O  N N 623 
PST "C2'"  C  N N 624 
PST "C1'"  C  N R 625 
PST N1     N  N N 626 
PST C2     C  N N 627 
PST O2     O  N N 628 
PST N3     N  N N 629 
PST C4     C  N N 630 
PST O4     O  N N 631 
PST C5     C  N N 632 
PST C5M    C  N N 633 
PST C6     C  N N 634 
PST HOP1   H  N N 635 
PST HOP2   H  N N 636 
PST "H5'"  H  N N 637 
PST "H5''" H  N N 638 
PST "H4'"  H  N N 639 
PST "H3'"  H  N N 640 
PST HO3    H  N N 641 
PST "H2'"  H  N N 642 
PST "H2''" H  N N 643 
PST "H1'"  H  N N 644 
PST HN3    H  N N 645 
PST H71    H  N N 646 
PST H72    H  N N 647 
PST H73    H  N N 648 
PST H6     H  N N 649 
SC  N1     N  N N 650 
SC  C2     C  N N 651 
SC  N3     N  N N 652 
SC  C4     C  N N 653 
SC  C5     C  N N 654 
SC  C6     C  N N 655 
SC  O2     O  N N 656 
SC  N4     N  N N 657 
SC  "C1'"  C  N R 658 
SC  "C2'"  C  N N 659 
SC  "C3'"  C  N S 660 
SC  "C4'"  C  N R 661 
SC  "O4'"  O  N N 662 
SC  "O3'"  O  N N 663 
SC  "C5'"  C  N N 664 
SC  "O5'"  O  N N 665 
SC  P      P  N N 666 
SC  OP1    O  N N 667 
SC  S2P    S  N N 668 
SC  OP3    O  N N 669 
SC  H5     H  N N 670 
SC  H6     H  N N 671 
SC  HN41   H  N N 672 
SC  HN42   H  N N 673 
SC  "H1'"  H  N N 674 
SC  "H2'"  H  N N 675 
SC  "H2''" H  N N 676 
SC  "H3'"  H  N N 677 
SC  "H4'"  H  N N 678 
SC  "HO3'" H  N N 679 
SC  "H5'"  H  N N 680 
SC  "H5''" H  N N 681 
SC  HOP1   H  N N 682 
SC  HOP3   H  N N 683 
SER N      N  N N 684 
SER CA     C  N S 685 
SER C      C  N N 686 
SER O      O  N N 687 
SER CB     C  N N 688 
SER OG     O  N N 689 
SER OXT    O  N N 690 
SER H      H  N N 691 
SER H2     H  N N 692 
SER HA     H  N N 693 
SER HB2    H  N N 694 
SER HB3    H  N N 695 
SER HG     H  N N 696 
SER HXT    H  N N 697 
THR N      N  N N 698 
THR CA     C  N S 699 
THR C      C  N N 700 
THR O      O  N N 701 
THR CB     C  N R 702 
THR OG1    O  N N 703 
THR CG2    C  N N 704 
THR OXT    O  N N 705 
THR H      H  N N 706 
THR H2     H  N N 707 
THR HA     H  N N 708 
THR HB     H  N N 709 
THR HG1    H  N N 710 
THR HG21   H  N N 711 
THR HG22   H  N N 712 
THR HG23   H  N N 713 
THR HXT    H  N N 714 
TRP N      N  N N 715 
TRP CA     C  N S 716 
TRP C      C  N N 717 
TRP O      O  N N 718 
TRP CB     C  N N 719 
TRP CG     C  Y N 720 
TRP CD1    C  Y N 721 
TRP CD2    C  Y N 722 
TRP NE1    N  Y N 723 
TRP CE2    C  Y N 724 
TRP CE3    C  Y N 725 
TRP CZ2    C  Y N 726 
TRP CZ3    C  Y N 727 
TRP CH2    C  Y N 728 
TRP OXT    O  N N 729 
TRP H      H  N N 730 
TRP H2     H  N N 731 
TRP HA     H  N N 732 
TRP HB2    H  N N 733 
TRP HB3    H  N N 734 
TRP HD1    H  N N 735 
TRP HE1    H  N N 736 
TRP HE3    H  N N 737 
TRP HZ2    H  N N 738 
TRP HZ3    H  N N 739 
TRP HH2    H  N N 740 
TRP HXT    H  N N 741 
TYR N      N  N N 742 
TYR CA     C  N S 743 
TYR C      C  N N 744 
TYR O      O  N N 745 
TYR CB     C  N N 746 
TYR CG     C  Y N 747 
TYR CD1    C  Y N 748 
TYR CD2    C  Y N 749 
TYR CE1    C  Y N 750 
TYR CE2    C  Y N 751 
TYR CZ     C  Y N 752 
TYR OH     O  N N 753 
TYR OXT    O  N N 754 
TYR H      H  N N 755 
TYR H2     H  N N 756 
TYR HA     H  N N 757 
TYR HB2    H  N N 758 
TYR HB3    H  N N 759 
TYR HD1    H  N N 760 
TYR HD2    H  N N 761 
TYR HE1    H  N N 762 
TYR HE2    H  N N 763 
TYR HH     H  N N 764 
TYR HXT    H  N N 765 
U   OP3    O  N N 766 
U   P      P  N N 767 
U   OP1    O  N N 768 
U   OP2    O  N N 769 
U   "O5'"  O  N N 770 
U   "C5'"  C  N N 771 
U   "C4'"  C  N R 772 
U   "O4'"  O  N N 773 
U   "C3'"  C  N S 774 
U   "O3'"  O  N N 775 
U   "C2'"  C  N R 776 
U   "O2'"  O  N N 777 
U   "C1'"  C  N R 778 
U   N1     N  N N 779 
U   C2     C  N N 780 
U   O2     O  N N 781 
U   N3     N  N N 782 
U   C4     C  N N 783 
U   O4     O  N N 784 
U   C5     C  N N 785 
U   C6     C  N N 786 
U   HOP3   H  N N 787 
U   HOP2   H  N N 788 
U   "H5'"  H  N N 789 
U   "H5''" H  N N 790 
U   "H4'"  H  N N 791 
U   "H3'"  H  N N 792 
U   "HO3'" H  N N 793 
U   "H2'"  H  N N 794 
U   "HO2'" H  N N 795 
U   "H1'"  H  N N 796 
U   H3     H  N N 797 
U   H5     H  N N 798 
U   H6     H  N N 799 
VAL N      N  N N 800 
VAL CA     C  N S 801 
VAL C      C  N N 802 
VAL O      O  N N 803 
VAL CB     C  N N 804 
VAL CG1    C  N N 805 
VAL CG2    C  N N 806 
VAL OXT    O  N N 807 
VAL H      H  N N 808 
VAL H2     H  N N 809 
VAL HA     H  N N 810 
VAL HB     H  N N 811 
VAL HG11   H  N N 812 
VAL HG12   H  N N 813 
VAL HG13   H  N N 814 
VAL HG21   H  N N 815 
VAL HG22   H  N N 816 
VAL HG23   H  N N 817 
VAL HXT    H  N N 818 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A   OP3   P      sing N N 1   
A   OP3   HOP3   sing N N 2   
A   P     OP1    doub N N 3   
A   P     OP2    sing N N 4   
A   P     "O5'"  sing N N 5   
A   OP2   HOP2   sing N N 6   
A   "O5'" "C5'"  sing N N 7   
A   "C5'" "C4'"  sing N N 8   
A   "C5'" "H5'"  sing N N 9   
A   "C5'" "H5''" sing N N 10  
A   "C4'" "O4'"  sing N N 11  
A   "C4'" "C3'"  sing N N 12  
A   "C4'" "H4'"  sing N N 13  
A   "O4'" "C1'"  sing N N 14  
A   "C3'" "O3'"  sing N N 15  
A   "C3'" "C2'"  sing N N 16  
A   "C3'" "H3'"  sing N N 17  
A   "O3'" "HO3'" sing N N 18  
A   "C2'" "O2'"  sing N N 19  
A   "C2'" "C1'"  sing N N 20  
A   "C2'" "H2'"  sing N N 21  
A   "O2'" "HO2'" sing N N 22  
A   "C1'" N9     sing N N 23  
A   "C1'" "H1'"  sing N N 24  
A   N9    C8     sing Y N 25  
A   N9    C4     sing Y N 26  
A   C8    N7     doub Y N 27  
A   C8    H8     sing N N 28  
A   N7    C5     sing Y N 29  
A   C5    C6     sing Y N 30  
A   C5    C4     doub Y N 31  
A   C6    N6     sing N N 32  
A   C6    N1     doub Y N 33  
A   N6    H61    sing N N 34  
A   N6    H62    sing N N 35  
A   N1    C2     sing Y N 36  
A   C2    N3     doub Y N 37  
A   C2    H2     sing N N 38  
A   N3    C4     sing Y N 39  
ALA N     CA     sing N N 40  
ALA N     H      sing N N 41  
ALA N     H2     sing N N 42  
ALA CA    C      sing N N 43  
ALA CA    CB     sing N N 44  
ALA CA    HA     sing N N 45  
ALA C     O      doub N N 46  
ALA C     OXT    sing N N 47  
ALA CB    HB1    sing N N 48  
ALA CB    HB2    sing N N 49  
ALA CB    HB3    sing N N 50  
ALA OXT   HXT    sing N N 51  
ARG N     CA     sing N N 52  
ARG N     H      sing N N 53  
ARG N     H2     sing N N 54  
ARG CA    C      sing N N 55  
ARG CA    CB     sing N N 56  
ARG CA    HA     sing N N 57  
ARG C     O      doub N N 58  
ARG C     OXT    sing N N 59  
ARG CB    CG     sing N N 60  
ARG CB    HB2    sing N N 61  
ARG CB    HB3    sing N N 62  
ARG CG    CD     sing N N 63  
ARG CG    HG2    sing N N 64  
ARG CG    HG3    sing N N 65  
ARG CD    NE     sing N N 66  
ARG CD    HD2    sing N N 67  
ARG CD    HD3    sing N N 68  
ARG NE    CZ     sing N N 69  
ARG NE    HE     sing N N 70  
ARG CZ    NH1    sing N N 71  
ARG CZ    NH2    doub N N 72  
ARG NH1   HH11   sing N N 73  
ARG NH1   HH12   sing N N 74  
ARG NH2   HH21   sing N N 75  
ARG NH2   HH22   sing N N 76  
ARG OXT   HXT    sing N N 77  
AS  P     OP1    sing N N 78  
AS  P     S2P    doub N N 79  
AS  P     OP3    sing N N 80  
AS  P     "O5'"  sing N N 81  
AS  OP1   HOP1   sing N N 82  
AS  OP3   HOP3   sing N N 83  
AS  "O5'" "C5'"  sing N N 84  
AS  "C5'" "C4'"  sing N N 85  
AS  "C5'" "H5'"  sing N N 86  
AS  "C5'" "H5''" sing N N 87  
AS  "C4'" "O4'"  sing N N 88  
AS  "C4'" "C3'"  sing N N 89  
AS  "C4'" "H4'"  sing N N 90  
AS  "O4'" "C1'"  sing N N 91  
AS  "C3'" "O3'"  sing N N 92  
AS  "C3'" "C2'"  sing N N 93  
AS  "C3'" "H3'"  sing N N 94  
AS  "O3'" "HO3'" sing N N 95  
AS  "C2'" "C1'"  sing N N 96  
AS  "C2'" "H2'"  sing N N 97  
AS  "C2'" "H2''" sing N N 98  
AS  "C1'" N9     sing N N 99  
AS  "C1'" "H1'"  sing N N 100 
AS  N9    C8     sing Y N 101 
AS  N9    C4     sing Y N 102 
AS  C8    N7     doub Y N 103 
AS  C8    H8     sing N N 104 
AS  N7    C5     sing Y N 105 
AS  C5    C6     sing Y N 106 
AS  C5    C4     doub Y N 107 
AS  C6    N6     sing N N 108 
AS  C6    N1     doub Y N 109 
AS  N6    HN61   sing N N 110 
AS  N6    HN62   sing N N 111 
AS  N1    C2     sing Y N 112 
AS  C2    N3     doub Y N 113 
AS  C2    H2     sing N N 114 
AS  N3    C4     sing Y N 115 
ASN N     CA     sing N N 116 
ASN N     H      sing N N 117 
ASN N     H2     sing N N 118 
ASN CA    C      sing N N 119 
ASN CA    CB     sing N N 120 
ASN CA    HA     sing N N 121 
ASN C     O      doub N N 122 
ASN C     OXT    sing N N 123 
ASN CB    CG     sing N N 124 
ASN CB    HB2    sing N N 125 
ASN CB    HB3    sing N N 126 
ASN CG    OD1    doub N N 127 
ASN CG    ND2    sing N N 128 
ASN ND2   HD21   sing N N 129 
ASN ND2   HD22   sing N N 130 
ASN OXT   HXT    sing N N 131 
ASP N     CA     sing N N 132 
ASP N     H      sing N N 133 
ASP N     H2     sing N N 134 
ASP CA    C      sing N N 135 
ASP CA    CB     sing N N 136 
ASP CA    HA     sing N N 137 
ASP C     O      doub N N 138 
ASP C     OXT    sing N N 139 
ASP CB    CG     sing N N 140 
ASP CB    HB2    sing N N 141 
ASP CB    HB3    sing N N 142 
ASP CG    OD1    doub N N 143 
ASP CG    OD2    sing N N 144 
ASP OD2   HD2    sing N N 145 
ASP OXT   HXT    sing N N 146 
C   OP3   P      sing N N 147 
C   OP3   HOP3   sing N N 148 
C   P     OP1    doub N N 149 
C   P     OP2    sing N N 150 
C   P     "O5'"  sing N N 151 
C   OP2   HOP2   sing N N 152 
C   "O5'" "C5'"  sing N N 153 
C   "C5'" "C4'"  sing N N 154 
C   "C5'" "H5'"  sing N N 155 
C   "C5'" "H5''" sing N N 156 
C   "C4'" "O4'"  sing N N 157 
C   "C4'" "C3'"  sing N N 158 
C   "C4'" "H4'"  sing N N 159 
C   "O4'" "C1'"  sing N N 160 
C   "C3'" "O3'"  sing N N 161 
C   "C3'" "C2'"  sing N N 162 
C   "C3'" "H3'"  sing N N 163 
C   "O3'" "HO3'" sing N N 164 
C   "C2'" "O2'"  sing N N 165 
C   "C2'" "C1'"  sing N N 166 
C   "C2'" "H2'"  sing N N 167 
C   "O2'" "HO2'" sing N N 168 
C   "C1'" N1     sing N N 169 
C   "C1'" "H1'"  sing N N 170 
C   N1    C2     sing N N 171 
C   N1    C6     sing N N 172 
C   C2    O2     doub N N 173 
C   C2    N3     sing N N 174 
C   N3    C4     doub N N 175 
C   C4    N4     sing N N 176 
C   C4    C5     sing N N 177 
C   N4    H41    sing N N 178 
C   N4    H42    sing N N 179 
C   C5    C6     doub N N 180 
C   C5    H5     sing N N 181 
C   C6    H6     sing N N 182 
CYS N     CA     sing N N 183 
CYS N     H      sing N N 184 
CYS N     H2     sing N N 185 
CYS CA    C      sing N N 186 
CYS CA    CB     sing N N 187 
CYS CA    HA     sing N N 188 
CYS C     O      doub N N 189 
CYS C     OXT    sing N N 190 
CYS CB    SG     sing N N 191 
CYS CB    HB2    sing N N 192 
CYS CB    HB3    sing N N 193 
CYS SG    HG     sing N N 194 
CYS OXT   HXT    sing N N 195 
DA  OP3   P      sing N N 196 
DA  OP3   HOP3   sing N N 197 
DA  P     OP1    doub N N 198 
DA  P     OP2    sing N N 199 
DA  P     "O5'"  sing N N 200 
DA  OP2   HOP2   sing N N 201 
DA  "O5'" "C5'"  sing N N 202 
DA  "C5'" "C4'"  sing N N 203 
DA  "C5'" "H5'"  sing N N 204 
DA  "C5'" "H5''" sing N N 205 
DA  "C4'" "O4'"  sing N N 206 
DA  "C4'" "C3'"  sing N N 207 
DA  "C4'" "H4'"  sing N N 208 
DA  "O4'" "C1'"  sing N N 209 
DA  "C3'" "O3'"  sing N N 210 
DA  "C3'" "C2'"  sing N N 211 
DA  "C3'" "H3'"  sing N N 212 
DA  "O3'" "HO3'" sing N N 213 
DA  "C2'" "C1'"  sing N N 214 
DA  "C2'" "H2'"  sing N N 215 
DA  "C2'" "H2''" sing N N 216 
DA  "C1'" N9     sing N N 217 
DA  "C1'" "H1'"  sing N N 218 
DA  N9    C8     sing Y N 219 
DA  N9    C4     sing Y N 220 
DA  C8    N7     doub Y N 221 
DA  C8    H8     sing N N 222 
DA  N7    C5     sing Y N 223 
DA  C5    C6     sing Y N 224 
DA  C5    C4     doub Y N 225 
DA  C6    N6     sing N N 226 
DA  C6    N1     doub Y N 227 
DA  N6    H61    sing N N 228 
DA  N6    H62    sing N N 229 
DA  N1    C2     sing Y N 230 
DA  C2    N3     doub Y N 231 
DA  C2    H2     sing N N 232 
DA  N3    C4     sing Y N 233 
DC  OP3   P      sing N N 234 
DC  OP3   HOP3   sing N N 235 
DC  P     OP1    doub N N 236 
DC  P     OP2    sing N N 237 
DC  P     "O5'"  sing N N 238 
DC  OP2   HOP2   sing N N 239 
DC  "O5'" "C5'"  sing N N 240 
DC  "C5'" "C4'"  sing N N 241 
DC  "C5'" "H5'"  sing N N 242 
DC  "C5'" "H5''" sing N N 243 
DC  "C4'" "O4'"  sing N N 244 
DC  "C4'" "C3'"  sing N N 245 
DC  "C4'" "H4'"  sing N N 246 
DC  "O4'" "C1'"  sing N N 247 
DC  "C3'" "O3'"  sing N N 248 
DC  "C3'" "C2'"  sing N N 249 
DC  "C3'" "H3'"  sing N N 250 
DC  "O3'" "HO3'" sing N N 251 
DC  "C2'" "C1'"  sing N N 252 
DC  "C2'" "H2'"  sing N N 253 
DC  "C2'" "H2''" sing N N 254 
DC  "C1'" N1     sing N N 255 
DC  "C1'" "H1'"  sing N N 256 
DC  N1    C2     sing N N 257 
DC  N1    C6     sing N N 258 
DC  C2    O2     doub N N 259 
DC  C2    N3     sing N N 260 
DC  N3    C4     doub N N 261 
DC  C4    N4     sing N N 262 
DC  C4    C5     sing N N 263 
DC  N4    H41    sing N N 264 
DC  N4    H42    sing N N 265 
DC  C5    C6     doub N N 266 
DC  C5    H5     sing N N 267 
DC  C6    H6     sing N N 268 
DG  OP3   P      sing N N 269 
DG  OP3   HOP3   sing N N 270 
DG  P     OP1    doub N N 271 
DG  P     OP2    sing N N 272 
DG  P     "O5'"  sing N N 273 
DG  OP2   HOP2   sing N N 274 
DG  "O5'" "C5'"  sing N N 275 
DG  "C5'" "C4'"  sing N N 276 
DG  "C5'" "H5'"  sing N N 277 
DG  "C5'" "H5''" sing N N 278 
DG  "C4'" "O4'"  sing N N 279 
DG  "C4'" "C3'"  sing N N 280 
DG  "C4'" "H4'"  sing N N 281 
DG  "O4'" "C1'"  sing N N 282 
DG  "C3'" "O3'"  sing N N 283 
DG  "C3'" "C2'"  sing N N 284 
DG  "C3'" "H3'"  sing N N 285 
DG  "O3'" "HO3'" sing N N 286 
DG  "C2'" "C1'"  sing N N 287 
DG  "C2'" "H2'"  sing N N 288 
DG  "C2'" "H2''" sing N N 289 
DG  "C1'" N9     sing N N 290 
DG  "C1'" "H1'"  sing N N 291 
DG  N9    C8     sing Y N 292 
DG  N9    C4     sing Y N 293 
DG  C8    N7     doub Y N 294 
DG  C8    H8     sing N N 295 
DG  N7    C5     sing Y N 296 
DG  C5    C6     sing N N 297 
DG  C5    C4     doub Y N 298 
DG  C6    O6     doub N N 299 
DG  C6    N1     sing N N 300 
DG  N1    C2     sing N N 301 
DG  N1    H1     sing N N 302 
DG  C2    N2     sing N N 303 
DG  C2    N3     doub N N 304 
DG  N2    H21    sing N N 305 
DG  N2    H22    sing N N 306 
DG  N3    C4     sing N N 307 
DT  OP3   P      sing N N 308 
DT  OP3   HOP3   sing N N 309 
DT  P     OP1    doub N N 310 
DT  P     OP2    sing N N 311 
DT  P     "O5'"  sing N N 312 
DT  OP2   HOP2   sing N N 313 
DT  "O5'" "C5'"  sing N N 314 
DT  "C5'" "C4'"  sing N N 315 
DT  "C5'" "H5'"  sing N N 316 
DT  "C5'" "H5''" sing N N 317 
DT  "C4'" "O4'"  sing N N 318 
DT  "C4'" "C3'"  sing N N 319 
DT  "C4'" "H4'"  sing N N 320 
DT  "O4'" "C1'"  sing N N 321 
DT  "C3'" "O3'"  sing N N 322 
DT  "C3'" "C2'"  sing N N 323 
DT  "C3'" "H3'"  sing N N 324 
DT  "O3'" "HO3'" sing N N 325 
DT  "C2'" "C1'"  sing N N 326 
DT  "C2'" "H2'"  sing N N 327 
DT  "C2'" "H2''" sing N N 328 
DT  "C1'" N1     sing N N 329 
DT  "C1'" "H1'"  sing N N 330 
DT  N1    C2     sing N N 331 
DT  N1    C6     sing N N 332 
DT  C2    O2     doub N N 333 
DT  C2    N3     sing N N 334 
DT  N3    C4     sing N N 335 
DT  N3    H3     sing N N 336 
DT  C4    O4     doub N N 337 
DT  C4    C5     sing N N 338 
DT  C5    C7     sing N N 339 
DT  C5    C6     doub N N 340 
DT  C7    H71    sing N N 341 
DT  C7    H72    sing N N 342 
DT  C7    H73    sing N N 343 
DT  C6    H6     sing N N 344 
G   OP3   P      sing N N 345 
G   OP3   HOP3   sing N N 346 
G   P     OP1    doub N N 347 
G   P     OP2    sing N N 348 
G   P     "O5'"  sing N N 349 
G   OP2   HOP2   sing N N 350 
G   "O5'" "C5'"  sing N N 351 
G   "C5'" "C4'"  sing N N 352 
G   "C5'" "H5'"  sing N N 353 
G   "C5'" "H5''" sing N N 354 
G   "C4'" "O4'"  sing N N 355 
G   "C4'" "C3'"  sing N N 356 
G   "C4'" "H4'"  sing N N 357 
G   "O4'" "C1'"  sing N N 358 
G   "C3'" "O3'"  sing N N 359 
G   "C3'" "C2'"  sing N N 360 
G   "C3'" "H3'"  sing N N 361 
G   "O3'" "HO3'" sing N N 362 
G   "C2'" "O2'"  sing N N 363 
G   "C2'" "C1'"  sing N N 364 
G   "C2'" "H2'"  sing N N 365 
G   "O2'" "HO2'" sing N N 366 
G   "C1'" N9     sing N N 367 
G   "C1'" "H1'"  sing N N 368 
G   N9    C8     sing Y N 369 
G   N9    C4     sing Y N 370 
G   C8    N7     doub Y N 371 
G   C8    H8     sing N N 372 
G   N7    C5     sing Y N 373 
G   C5    C6     sing N N 374 
G   C5    C4     doub Y N 375 
G   C6    O6     doub N N 376 
G   C6    N1     sing N N 377 
G   N1    C2     sing N N 378 
G   N1    H1     sing N N 379 
G   C2    N2     sing N N 380 
G   C2    N3     doub N N 381 
G   N2    H21    sing N N 382 
G   N2    H22    sing N N 383 
G   N3    C4     sing N N 384 
GLN N     CA     sing N N 385 
GLN N     H      sing N N 386 
GLN N     H2     sing N N 387 
GLN CA    C      sing N N 388 
GLN CA    CB     sing N N 389 
GLN CA    HA     sing N N 390 
GLN C     O      doub N N 391 
GLN C     OXT    sing N N 392 
GLN CB    CG     sing N N 393 
GLN CB    HB2    sing N N 394 
GLN CB    HB3    sing N N 395 
GLN CG    CD     sing N N 396 
GLN CG    HG2    sing N N 397 
GLN CG    HG3    sing N N 398 
GLN CD    OE1    doub N N 399 
GLN CD    NE2    sing N N 400 
GLN NE2   HE21   sing N N 401 
GLN NE2   HE22   sing N N 402 
GLN OXT   HXT    sing N N 403 
GLU N     CA     sing N N 404 
GLU N     H      sing N N 405 
GLU N     H2     sing N N 406 
GLU CA    C      sing N N 407 
GLU CA    CB     sing N N 408 
GLU CA    HA     sing N N 409 
GLU C     O      doub N N 410 
GLU C     OXT    sing N N 411 
GLU CB    CG     sing N N 412 
GLU CB    HB2    sing N N 413 
GLU CB    HB3    sing N N 414 
GLU CG    CD     sing N N 415 
GLU CG    HG2    sing N N 416 
GLU CG    HG3    sing N N 417 
GLU CD    OE1    doub N N 418 
GLU CD    OE2    sing N N 419 
GLU OE2   HE2    sing N N 420 
GLU OXT   HXT    sing N N 421 
GLY N     CA     sing N N 422 
GLY N     H      sing N N 423 
GLY N     H2     sing N N 424 
GLY CA    C      sing N N 425 
GLY CA    HA2    sing N N 426 
GLY CA    HA3    sing N N 427 
GLY C     O      doub N N 428 
GLY C     OXT    sing N N 429 
GLY OXT   HXT    sing N N 430 
GS  P     OP1    doub N N 431 
GS  P     S2P    sing N N 432 
GS  P     OP3    sing N N 433 
GS  P     "O5'"  sing N N 434 
GS  S2P   HSP2   sing N N 435 
GS  OP3   HOP3   sing N N 436 
GS  "O5'" "C5'"  sing N N 437 
GS  "C5'" "C4'"  sing N N 438 
GS  "C5'" "H5'"  sing N N 439 
GS  "C5'" "H5''" sing N N 440 
GS  "C4'" "O4'"  sing N N 441 
GS  "C4'" "C3'"  sing N N 442 
GS  "C4'" "H4'"  sing N N 443 
GS  "O4'" "C1'"  sing N N 444 
GS  "C3'" "O3'"  sing N N 445 
GS  "C3'" "C2'"  sing N N 446 
GS  "C3'" "H3'"  sing N N 447 
GS  "O3'" "HO3'" sing N N 448 
GS  "C2'" "C1'"  sing N N 449 
GS  "C2'" "H2'"  sing N N 450 
GS  "C2'" "H2''" sing N N 451 
GS  "C1'" N9     sing N N 452 
GS  "C1'" "H1'"  sing N N 453 
GS  N9    C8     sing Y N 454 
GS  N9    C4     sing Y N 455 
GS  C8    N7     doub Y N 456 
GS  C8    H8     sing N N 457 
GS  N7    C5     sing Y N 458 
GS  C5    C6     sing N N 459 
GS  C5    C4     doub Y N 460 
GS  C6    O6     doub N N 461 
GS  C6    N1     sing N N 462 
GS  N1    C2     sing N N 463 
GS  N1    HN1    sing N N 464 
GS  C2    N2     sing N N 465 
GS  C2    N3     doub N N 466 
GS  N2    HN21   sing N N 467 
GS  N2    HN22   sing N N 468 
GS  N3    C4     sing N N 469 
HIS N     CA     sing N N 470 
HIS N     H      sing N N 471 
HIS N     H2     sing N N 472 
HIS CA    C      sing N N 473 
HIS CA    CB     sing N N 474 
HIS CA    HA     sing N N 475 
HIS C     O      doub N N 476 
HIS C     OXT    sing N N 477 
HIS CB    CG     sing N N 478 
HIS CB    HB2    sing N N 479 
HIS CB    HB3    sing N N 480 
HIS CG    ND1    sing Y N 481 
HIS CG    CD2    doub Y N 482 
HIS ND1   CE1    doub Y N 483 
HIS ND1   HD1    sing N N 484 
HIS CD2   NE2    sing Y N 485 
HIS CD2   HD2    sing N N 486 
HIS CE1   NE2    sing Y N 487 
HIS CE1   HE1    sing N N 488 
HIS NE2   HE2    sing N N 489 
HIS OXT   HXT    sing N N 490 
ILE N     CA     sing N N 491 
ILE N     H      sing N N 492 
ILE N     H2     sing N N 493 
ILE CA    C      sing N N 494 
ILE CA    CB     sing N N 495 
ILE CA    HA     sing N N 496 
ILE C     O      doub N N 497 
ILE C     OXT    sing N N 498 
ILE CB    CG1    sing N N 499 
ILE CB    CG2    sing N N 500 
ILE CB    HB     sing N N 501 
ILE CG1   CD1    sing N N 502 
ILE CG1   HG12   sing N N 503 
ILE CG1   HG13   sing N N 504 
ILE CG2   HG21   sing N N 505 
ILE CG2   HG22   sing N N 506 
ILE CG2   HG23   sing N N 507 
ILE CD1   HD11   sing N N 508 
ILE CD1   HD12   sing N N 509 
ILE CD1   HD13   sing N N 510 
ILE OXT   HXT    sing N N 511 
LEU N     CA     sing N N 512 
LEU N     H      sing N N 513 
LEU N     H2     sing N N 514 
LEU CA    C      sing N N 515 
LEU CA    CB     sing N N 516 
LEU CA    HA     sing N N 517 
LEU C     O      doub N N 518 
LEU C     OXT    sing N N 519 
LEU CB    CG     sing N N 520 
LEU CB    HB2    sing N N 521 
LEU CB    HB3    sing N N 522 
LEU CG    CD1    sing N N 523 
LEU CG    CD2    sing N N 524 
LEU CG    HG     sing N N 525 
LEU CD1   HD11   sing N N 526 
LEU CD1   HD12   sing N N 527 
LEU CD1   HD13   sing N N 528 
LEU CD2   HD21   sing N N 529 
LEU CD2   HD22   sing N N 530 
LEU CD2   HD23   sing N N 531 
LEU OXT   HXT    sing N N 532 
LYS N     CA     sing N N 533 
LYS N     H      sing N N 534 
LYS N     H2     sing N N 535 
LYS CA    C      sing N N 536 
LYS CA    CB     sing N N 537 
LYS CA    HA     sing N N 538 
LYS C     O      doub N N 539 
LYS C     OXT    sing N N 540 
LYS CB    CG     sing N N 541 
LYS CB    HB2    sing N N 542 
LYS CB    HB3    sing N N 543 
LYS CG    CD     sing N N 544 
LYS CG    HG2    sing N N 545 
LYS CG    HG3    sing N N 546 
LYS CD    CE     sing N N 547 
LYS CD    HD2    sing N N 548 
LYS CD    HD3    sing N N 549 
LYS CE    NZ     sing N N 550 
LYS CE    HE2    sing N N 551 
LYS CE    HE3    sing N N 552 
LYS NZ    HZ1    sing N N 553 
LYS NZ    HZ2    sing N N 554 
LYS NZ    HZ3    sing N N 555 
LYS OXT   HXT    sing N N 556 
MET N     CA     sing N N 557 
MET N     H      sing N N 558 
MET N     H2     sing N N 559 
MET CA    C      sing N N 560 
MET CA    CB     sing N N 561 
MET CA    HA     sing N N 562 
MET C     O      doub N N 563 
MET C     OXT    sing N N 564 
MET CB    CG     sing N N 565 
MET CB    HB2    sing N N 566 
MET CB    HB3    sing N N 567 
MET CG    SD     sing N N 568 
MET CG    HG2    sing N N 569 
MET CG    HG3    sing N N 570 
MET SD    CE     sing N N 571 
MET CE    HE1    sing N N 572 
MET CE    HE2    sing N N 573 
MET CE    HE3    sing N N 574 
MET OXT   HXT    sing N N 575 
PHE N     CA     sing N N 576 
PHE N     H      sing N N 577 
PHE N     H2     sing N N 578 
PHE CA    C      sing N N 579 
PHE CA    CB     sing N N 580 
PHE CA    HA     sing N N 581 
PHE C     O      doub N N 582 
PHE C     OXT    sing N N 583 
PHE CB    CG     sing N N 584 
PHE CB    HB2    sing N N 585 
PHE CB    HB3    sing N N 586 
PHE CG    CD1    doub Y N 587 
PHE CG    CD2    sing Y N 588 
PHE CD1   CE1    sing Y N 589 
PHE CD1   HD1    sing N N 590 
PHE CD2   CE2    doub Y N 591 
PHE CD2   HD2    sing N N 592 
PHE CE1   CZ     doub Y N 593 
PHE CE1   HE1    sing N N 594 
PHE CE2   CZ     sing Y N 595 
PHE CE2   HE2    sing N N 596 
PHE CZ    HZ     sing N N 597 
PHE OXT   HXT    sing N N 598 
PRO N     CA     sing N N 599 
PRO N     CD     sing N N 600 
PRO N     H      sing N N 601 
PRO CA    C      sing N N 602 
PRO CA    CB     sing N N 603 
PRO CA    HA     sing N N 604 
PRO C     O      doub N N 605 
PRO C     OXT    sing N N 606 
PRO CB    CG     sing N N 607 
PRO CB    HB2    sing N N 608 
PRO CB    HB3    sing N N 609 
PRO CG    CD     sing N N 610 
PRO CG    HG2    sing N N 611 
PRO CG    HG3    sing N N 612 
PRO CD    HD2    sing N N 613 
PRO CD    HD3    sing N N 614 
PRO OXT   HXT    sing N N 615 
PST P     OP1    sing N N 616 
PST P     OP2    sing N N 617 
PST P     SP     doub N N 618 
PST P     "O5'"  sing N N 619 
PST OP1   HOP1   sing N N 620 
PST OP2   HOP2   sing N N 621 
PST "O5'" "C5'"  sing N N 622 
PST "C5'" "C4'"  sing N N 623 
PST "C5'" "H5'"  sing N N 624 
PST "C5'" "H5''" sing N N 625 
PST "C4'" "O4'"  sing N N 626 
PST "C4'" "C3'"  sing N N 627 
PST "C4'" "H4'"  sing N N 628 
PST "O4'" "C1'"  sing N N 629 
PST "C3'" "O3'"  sing N N 630 
PST "C3'" "C2'"  sing N N 631 
PST "C3'" "H3'"  sing N N 632 
PST "O3'" HO3    sing N N 633 
PST "C2'" "C1'"  sing N N 634 
PST "C2'" "H2'"  sing N N 635 
PST "C2'" "H2''" sing N N 636 
PST "C1'" N1     sing N N 637 
PST "C1'" "H1'"  sing N N 638 
PST N1    C2     sing N N 639 
PST N1    C6     sing N N 640 
PST C2    O2     doub N N 641 
PST C2    N3     sing N N 642 
PST N3    C4     sing N N 643 
PST N3    HN3    sing N N 644 
PST C4    O4     doub N N 645 
PST C4    C5     sing N N 646 
PST C5    C5M    sing N N 647 
PST C5    C6     doub N N 648 
PST C5M   H71    sing N N 649 
PST C5M   H72    sing N N 650 
PST C5M   H73    sing N N 651 
PST C6    H6     sing N N 652 
SC  N1    C2     sing N N 653 
SC  N1    C6     sing N N 654 
SC  N1    "C1'"  sing N N 655 
SC  C2    N3     sing N N 656 
SC  C2    O2     doub N N 657 
SC  N3    C4     doub N N 658 
SC  C4    C5     sing N N 659 
SC  C4    N4     sing N N 660 
SC  C5    C6     doub N N 661 
SC  C5    H5     sing N N 662 
SC  C6    H6     sing N N 663 
SC  N4    HN41   sing N N 664 
SC  N4    HN42   sing N N 665 
SC  "C1'" "C2'"  sing N N 666 
SC  "C1'" "O4'"  sing N N 667 
SC  "C1'" "H1'"  sing N N 668 
SC  "C2'" "C3'"  sing N N 669 
SC  "C2'" "H2'"  sing N N 670 
SC  "C2'" "H2''" sing N N 671 
SC  "C3'" "C4'"  sing N N 672 
SC  "C3'" "O3'"  sing N N 673 
SC  "C3'" "H3'"  sing N N 674 
SC  "C4'" "O4'"  sing N N 675 
SC  "C4'" "C5'"  sing N N 676 
SC  "C4'" "H4'"  sing N N 677 
SC  "O3'" "HO3'" sing N N 678 
SC  "C5'" "O5'"  sing N N 679 
SC  "C5'" "H5'"  sing N N 680 
SC  "C5'" "H5''" sing N N 681 
SC  "O5'" P      sing N N 682 
SC  P     OP1    sing N N 683 
SC  P     S2P    doub N N 684 
SC  P     OP3    sing N N 685 
SC  OP1   HOP1   sing N N 686 
SC  OP3   HOP3   sing N N 687 
SER N     CA     sing N N 688 
SER N     H      sing N N 689 
SER N     H2     sing N N 690 
SER CA    C      sing N N 691 
SER CA    CB     sing N N 692 
SER CA    HA     sing N N 693 
SER C     O      doub N N 694 
SER C     OXT    sing N N 695 
SER CB    OG     sing N N 696 
SER CB    HB2    sing N N 697 
SER CB    HB3    sing N N 698 
SER OG    HG     sing N N 699 
SER OXT   HXT    sing N N 700 
THR N     CA     sing N N 701 
THR N     H      sing N N 702 
THR N     H2     sing N N 703 
THR CA    C      sing N N 704 
THR CA    CB     sing N N 705 
THR CA    HA     sing N N 706 
THR C     O      doub N N 707 
THR C     OXT    sing N N 708 
THR CB    OG1    sing N N 709 
THR CB    CG2    sing N N 710 
THR CB    HB     sing N N 711 
THR OG1   HG1    sing N N 712 
THR CG2   HG21   sing N N 713 
THR CG2   HG22   sing N N 714 
THR CG2   HG23   sing N N 715 
THR OXT   HXT    sing N N 716 
TRP N     CA     sing N N 717 
TRP N     H      sing N N 718 
TRP N     H2     sing N N 719 
TRP CA    C      sing N N 720 
TRP CA    CB     sing N N 721 
TRP CA    HA     sing N N 722 
TRP C     O      doub N N 723 
TRP C     OXT    sing N N 724 
TRP CB    CG     sing N N 725 
TRP CB    HB2    sing N N 726 
TRP CB    HB3    sing N N 727 
TRP CG    CD1    doub Y N 728 
TRP CG    CD2    sing Y N 729 
TRP CD1   NE1    sing Y N 730 
TRP CD1   HD1    sing N N 731 
TRP CD2   CE2    doub Y N 732 
TRP CD2   CE3    sing Y N 733 
TRP NE1   CE2    sing Y N 734 
TRP NE1   HE1    sing N N 735 
TRP CE2   CZ2    sing Y N 736 
TRP CE3   CZ3    doub Y N 737 
TRP CE3   HE3    sing N N 738 
TRP CZ2   CH2    doub Y N 739 
TRP CZ2   HZ2    sing N N 740 
TRP CZ3   CH2    sing Y N 741 
TRP CZ3   HZ3    sing N N 742 
TRP CH2   HH2    sing N N 743 
TRP OXT   HXT    sing N N 744 
TYR N     CA     sing N N 745 
TYR N     H      sing N N 746 
TYR N     H2     sing N N 747 
TYR CA    C      sing N N 748 
TYR CA    CB     sing N N 749 
TYR CA    HA     sing N N 750 
TYR C     O      doub N N 751 
TYR C     OXT    sing N N 752 
TYR CB    CG     sing N N 753 
TYR CB    HB2    sing N N 754 
TYR CB    HB3    sing N N 755 
TYR CG    CD1    doub Y N 756 
TYR CG    CD2    sing Y N 757 
TYR CD1   CE1    sing Y N 758 
TYR CD1   HD1    sing N N 759 
TYR CD2   CE2    doub Y N 760 
TYR CD2   HD2    sing N N 761 
TYR CE1   CZ     doub Y N 762 
TYR CE1   HE1    sing N N 763 
TYR CE2   CZ     sing Y N 764 
TYR CE2   HE2    sing N N 765 
TYR CZ    OH     sing N N 766 
TYR OH    HH     sing N N 767 
TYR OXT   HXT    sing N N 768 
U   OP3   P      sing N N 769 
U   OP3   HOP3   sing N N 770 
U   P     OP1    doub N N 771 
U   P     OP2    sing N N 772 
U   P     "O5'"  sing N N 773 
U   OP2   HOP2   sing N N 774 
U   "O5'" "C5'"  sing N N 775 
U   "C5'" "C4'"  sing N N 776 
U   "C5'" "H5'"  sing N N 777 
U   "C5'" "H5''" sing N N 778 
U   "C4'" "O4'"  sing N N 779 
U   "C4'" "C3'"  sing N N 780 
U   "C4'" "H4'"  sing N N 781 
U   "O4'" "C1'"  sing N N 782 
U   "C3'" "O3'"  sing N N 783 
U   "C3'" "C2'"  sing N N 784 
U   "C3'" "H3'"  sing N N 785 
U   "O3'" "HO3'" sing N N 786 
U   "C2'" "O2'"  sing N N 787 
U   "C2'" "C1'"  sing N N 788 
U   "C2'" "H2'"  sing N N 789 
U   "O2'" "HO2'" sing N N 790 
U   "C1'" N1     sing N N 791 
U   "C1'" "H1'"  sing N N 792 
U   N1    C2     sing N N 793 
U   N1    C6     sing N N 794 
U   C2    O2     doub N N 795 
U   C2    N3     sing N N 796 
U   N3    C4     sing N N 797 
U   N3    H3     sing N N 798 
U   C4    O4     doub N N 799 
U   C4    C5     sing N N 800 
U   C5    C6     doub N N 801 
U   C5    H5     sing N N 802 
U   C6    H6     sing N N 803 
VAL N     CA     sing N N 804 
VAL N     H      sing N N 805 
VAL N     H2     sing N N 806 
VAL CA    C      sing N N 807 
VAL CA    CB     sing N N 808 
VAL CA    HA     sing N N 809 
VAL C     O      doub N N 810 
VAL C     OXT    sing N N 811 
VAL CB    CG1    sing N N 812 
VAL CB    CG2    sing N N 813 
VAL CB    HB     sing N N 814 
VAL CG1   HG11   sing N N 815 
VAL CG1   HG12   sing N N 816 
VAL CG1   HG13   sing N N 817 
VAL CG2   HG21   sing N N 818 
VAL CG2   HG22   sing N N 819 
VAL CG2   HG23   sing N N 820 
VAL OXT   HXT    sing N N 821 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-08-01 
_em_admin.deposition_site    PDBJ 
_em_admin.entry_id           9IZP 
_em_admin.last_update        2025-06-11 
_em_admin.map_release_date   2025-06-11 
_em_admin.title              'Cryo-EM structure of CasLambda2-crRNA-target DNA ternary complex in the incompetent state' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_molwt.entity_assembly_id   1 
_em_entity_assembly_molwt.experimental_flag    NO 
_em_entity_assembly_molwt.id                   1 
_em_entity_assembly_molwt.units                ? 
_em_entity_assembly_molwt.value                ? 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          32644 
_em_entity_assembly_naturalsource.organism             unidentified 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          562 
_em_entity_assembly_recombinant.organism             'Escherichia coli' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         50.0 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'MODEL REFINEMENT'              ? 1  ? ? ? PHENIX 1.21_5207: 
'IMAGE ACQUISITION'             ? 2  1 1 1 ?      ?          
'PARTICLE SELECTION'            ? 3  1 1 1 ?      ?          
'VOLUME SELECTION'              ? 4  1 1 1 ?      ?          
CLASSIFICATION                  ? 5  1 1 1 ?      ?          
MASKING                         ? 6  1 1 1 ?      ?          
RECONSTRUCTION                  ? 7  1 1 1 ?      ?          
'INITIAL EULER ASSIGNMENT'      ? 8  1 1 1 ?      ?          
'FINAL EULER ASSIGNMENT'        ? 9  1 1 1 ?      ?          
'CTF CORRECTION'                ? 10 1 1 1 ?      ?          
'LAYERLINE INDEXING'            ? 11 1 1 1 ?      ?          
'DIFFRACTION INDEXING'          ? 12 1 1 1 ?      ?          
'MODEL FITTING'                 ? 13 1 1 1 ?      ?          
'SERIES ALIGNMENT'              ? 14 1 1 1 ?      ?          
'MOLECULAR REPLACEMENT'         ? 15 1 1 1 ?      ?          
'LATTICE DISTORTION CORRECTION' ? 16 1 1 1 ?      ?          
'SYMMETRY DETERMINATION'        ? 17 1 1 1 ?      ?          
'CRYSTALLOGRAPHY MERGING'       ? 18 1 1 1 ?      ?          
OTHER                           ? 19 1 1 1 ?      ?          
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
loop_
_ndb_struct_conf_na.entry_id 
_ndb_struct_conf_na.feature 
9IZP 'double helix'        
9IZP 'a-form double helix' 
9IZP 'b-form double helix' 
# 
loop_
_ndb_struct_na_base_pair.model_number 
_ndb_struct_na_base_pair.i_label_asym_id 
_ndb_struct_na_base_pair.i_label_comp_id 
_ndb_struct_na_base_pair.i_label_seq_id 
_ndb_struct_na_base_pair.i_symmetry 
_ndb_struct_na_base_pair.j_label_asym_id 
_ndb_struct_na_base_pair.j_label_comp_id 
_ndb_struct_na_base_pair.j_label_seq_id 
_ndb_struct_na_base_pair.j_symmetry 
_ndb_struct_na_base_pair.shear 
_ndb_struct_na_base_pair.stretch 
_ndb_struct_na_base_pair.stagger 
_ndb_struct_na_base_pair.buckle 
_ndb_struct_na_base_pair.propeller 
_ndb_struct_na_base_pair.opening 
_ndb_struct_na_base_pair.pair_number 
_ndb_struct_na_base_pair.pair_name 
_ndb_struct_na_base_pair.i_auth_asym_id 
_ndb_struct_na_base_pair.i_auth_seq_id 
_ndb_struct_na_base_pair.i_PDB_ins_code 
_ndb_struct_na_base_pair.j_auth_asym_id 
_ndb_struct_na_base_pair.j_auth_seq_id 
_ndb_struct_na_base_pair.j_PDB_ins_code 
_ndb_struct_na_base_pair.hbond_type_28 
_ndb_struct_na_base_pair.hbond_type_12 
1 B G  6  1_555 B C  38 1_555 -0.270 -0.094 -0.148 -7.951  -7.454  -0.135 1  B_G-33:C-1_B   B -33 ? B -1  ? 19 1 
1 B U  7  1_555 B A  37 1_555 -0.082 -0.096 0.117  -4.129  -7.416  0.582  2  B_U-32:A-2_B   B -32 ? B -2  ? 20 1 
1 B U  8  1_555 B A  36 1_555 0.028  -0.185 0.041  0.484   -4.961  4.266  3  B_U-31:A-3_B   B -31 ? B -3  ? 20 1 
1 B G  9  1_555 B C  35 1_555 -0.153 -0.154 0.225  6.414   -1.755  -1.107 4  B_G-30:C-4_B   B -30 ? B -4  ? 19 1 
1 B U  10 1_555 B A  34 1_555 -0.002 -0.144 0.060  10.547  1.778   6.951  5  B_U-29:A-5_B   B -29 ? B -5  ? 20 1 
1 B A  11 1_555 B U  31 1_555 0.099  0.381  0.422  2.384   -18.693 1.478  6  B_A-28:U-8_B   B -28 ? B -8  ? 20 1 
1 B A  13 1_555 B U  30 1_555 0.084  -0.150 0.587  -1.377  -8.605  -3.189 7  B_A-26:U-9_B   B -26 ? B -9  ? 20 1 
1 B U  14 1_555 B A  29 1_555 -0.039 -0.089 0.198  -1.999  -9.877  -0.581 8  B_U-25:A-10_B  B -25 ? B -10 ? 20 1 
1 B A  15 1_555 B U  28 1_555 0.038  -0.113 0.464  -2.815  -6.752  -0.121 9  B_A-24:U-11_B  B -24 ? B -11 ? 20 1 
1 B U  16 1_555 B G  27 1_555 2.183  -0.449 0.370  -0.300  -4.547  -3.294 10 B_U-23:G-12_B  B -23 ? B -12 ? 28 1 
1 B C  18 1_555 B G  26 1_555 0.214  -0.124 -0.188 -2.661  -4.549  1.957  11 B_C-21:G-13_B  B -21 ? B -13 ? 19 1 
1 B U  19 1_555 B A  25 1_555 -0.020 -0.016 -0.056 -2.270  -1.127  3.391  12 B_U-20:A-14_B  B -20 ? B -14 ? 20 1 
1 B G  39 1_555 D DC 30 1_555 -0.183 -0.200 -0.853 -12.173 -3.793  -0.444 13 B_G0:DC20_D    B 0   ? D 20  ? 19 1 
1 B G  40 1_555 D DC 29 1_555 -0.228 -0.139 -0.590 -14.674 -5.158  -0.848 14 B_G1:DC19_D    B 1   ? D 19  ? 19 1 
1 B A  41 1_555 D DT 28 1_555 0.065  -0.111 -0.284 -7.882  -5.943  1.059  15 B_A2:DT18_D    B 2   ? D 18  ? 20 1 
1 B G  42 1_555 D DC 27 1_555 -0.180 -0.102 -0.144 -2.450  -4.292  0.260  16 B_G3:DC17_D    B 3   ? D 17  ? 19 1 
1 B A  43 1_555 D DT 26 1_555 0.120  -0.134 -0.073 -3.483  -6.017  0.668  17 B_A4:DT16_D    B 4   ? D 16  ? 20 1 
1 B U  44 1_555 D DA 25 1_555 -0.009 -0.157 -0.103 -2.265  -5.784  0.487  18 B_U5:DA15_D    B 5   ? D 15  ? 20 1 
1 B G  45 1_555 D DC 24 1_555 -0.277 -0.139 -0.269 -11.769 -12.785 2.315  19 B_G6:DC14_D    B 6   ? D 14  ? 19 1 
1 B A  46 1_555 D DT 23 1_555 0.216  -0.055 -0.339 -10.341 -8.803  -1.965 20 B_A7:DT13_D    B 7   ? D 13  ? 20 1 
1 B G  47 1_555 D DC 22 1_555 -0.213 -0.142 0.288  0.316   -9.046  0.494  21 B_G8:DC12_D    B 8   ? D 12  ? 19 1 
1 B G  48 1_555 D DC 21 1_555 -0.197 -0.134 0.215  -1.190  -8.607  1.278  22 B_G9:DC11_D    B 9   ? D 11  ? 19 1 
1 B U  49 1_555 D DA 20 1_555 1.184  0.080  0.457  -7.428  -8.626  7.071  23 B_U10:DA10_D   B 10  ? D 10  ? 20 1 
1 B G  50 1_555 D DC 19 1_555 -0.258 -0.165 -0.235 -5.328  -6.704  1.024  24 B_G11:DC9_D    B 11  ? D 9   ? 19 1 
1 B C  51 1_555 D DG 18 1_555 0.199  -0.129 -0.015 -1.456  -6.466  0.046  25 B_C12:DG8_D    B 12  ? D 8   ? 19 1 
1 B G  52 1_555 D DC 17 1_555 -0.209 0.394  0.093  -7.482  -20.744 5.558  26 B_G13:DC7_D    B 13  ? D 7   ? 19 1 
1 B C  53 1_555 D DG 16 1_555 0.181  -0.126 0.139  -4.869  -10.139 0.006  27 B_C14:DG6_D    B 14  ? D 6   ? 19 1 
1 B G  54 1_555 D DC 15 1_555 -0.221 -0.118 -0.469 -3.520  -5.960  1.131  28 B_G15:DC5_D    B 15  ? D 5   ? 19 1 
1 B U  55 1_555 D DA 14 1_555 -0.030 -0.153 -0.275 2.057   -3.788  5.630  29 B_U16:DA4_D    B 16  ? D 4   ? 20 1 
1 C DT 1  1_555 D DA 40 1_555 -0.154 -0.148 -0.327 -4.569  -6.426  2.978  30 C_DT-10:DA30_D C -10 ? D 30  ? 20 1 
1 C DG 2  1_555 D DC 39 1_555 -0.245 -0.200 -0.585 -7.050  -2.029  2.026  31 C_DG-9:DC29_D  C -9  ? D 29  ? 19 1 
1 C DT 3  1_555 D DA 38 1_555 -0.151 -0.165 -0.080 3.141   -2.353  0.109  32 C_DT-8:DA28_D  C -8  ? D 28  ? 20 1 
1 C DC 4  1_555 D DG 37 1_555 0.240  -0.177 0.018  5.207   -6.462  1.410  33 C_DC-7:DG27_D  C -7  ? D 27  ? 19 1 
1 C DT 5  1_555 D DA 36 1_555 -0.227 -0.167 0.162  2.416   -9.193  0.243  34 C_DT-6:DA26_D  C -6  ? D 26  ? 20 1 
1 C DA 6  1_555 D DT 35 1_555 0.078  -0.115 0.157  -2.949  -10.184 1.563  35 C_DA-5:DT25_D  C -5  ? D 25  ? 20 1 
1 C DT 7  1_555 D DA 34 1_555 -0.094 -0.112 0.060  -3.414  -12.715 0.511  36 C_DT-4:DA24_D  C -4  ? D 24  ? 20 1 
1 C DT 8  1_555 D DA 33 1_555 -0.025 -0.169 -0.042 -2.984  -12.468 2.236  37 C_DT-3:DA23_D  C -3  ? D 23  ? 20 1 
1 C DT 9  1_555 D DA 32 1_555 -0.113 -0.170 -0.080 0.379   -3.381  1.466  38 C_DT-2:DA22_D  C -2  ? D 22  ? 20 1 
1 C DA 10 1_555 D DT 31 1_555 0.030  -0.182 -0.169 7.258   2.183   5.209  39 C_DA-1:DT21_D  C -1  ? D 21  ? 20 1 
# 
loop_
_ndb_struct_na_base_pair_step.model_number 
_ndb_struct_na_base_pair_step.i_label_asym_id_1 
_ndb_struct_na_base_pair_step.i_label_comp_id_1 
_ndb_struct_na_base_pair_step.i_label_seq_id_1 
_ndb_struct_na_base_pair_step.i_symmetry_1 
_ndb_struct_na_base_pair_step.j_label_asym_id_1 
_ndb_struct_na_base_pair_step.j_label_comp_id_1 
_ndb_struct_na_base_pair_step.j_label_seq_id_1 
_ndb_struct_na_base_pair_step.j_symmetry_1 
_ndb_struct_na_base_pair_step.i_label_asym_id_2 
_ndb_struct_na_base_pair_step.i_label_comp_id_2 
_ndb_struct_na_base_pair_step.i_label_seq_id_2 
_ndb_struct_na_base_pair_step.i_symmetry_2 
_ndb_struct_na_base_pair_step.j_label_asym_id_2 
_ndb_struct_na_base_pair_step.j_label_comp_id_2 
_ndb_struct_na_base_pair_step.j_label_seq_id_2 
_ndb_struct_na_base_pair_step.j_symmetry_2 
_ndb_struct_na_base_pair_step.shift 
_ndb_struct_na_base_pair_step.slide 
_ndb_struct_na_base_pair_step.rise 
_ndb_struct_na_base_pair_step.tilt 
_ndb_struct_na_base_pair_step.roll 
_ndb_struct_na_base_pair_step.twist 
_ndb_struct_na_base_pair_step.x_displacement 
_ndb_struct_na_base_pair_step.y_displacement 
_ndb_struct_na_base_pair_step.helical_rise 
_ndb_struct_na_base_pair_step.inclination 
_ndb_struct_na_base_pair_step.tip 
_ndb_struct_na_base_pair_step.helical_twist 
_ndb_struct_na_base_pair_step.step_number 
_ndb_struct_na_base_pair_step.step_name 
_ndb_struct_na_base_pair_step.i_auth_asym_id_1 
_ndb_struct_na_base_pair_step.i_auth_seq_id_1 
_ndb_struct_na_base_pair_step.i_PDB_ins_code_1 
_ndb_struct_na_base_pair_step.j_auth_asym_id_1 
_ndb_struct_na_base_pair_step.j_auth_seq_id_1 
_ndb_struct_na_base_pair_step.j_PDB_ins_code_1 
_ndb_struct_na_base_pair_step.i_auth_asym_id_2 
_ndb_struct_na_base_pair_step.i_auth_seq_id_2 
_ndb_struct_na_base_pair_step.i_PDB_ins_code_2 
_ndb_struct_na_base_pair_step.j_auth_asym_id_2 
_ndb_struct_na_base_pair_step.j_auth_seq_id_2 
_ndb_struct_na_base_pair_step.j_PDB_ins_code_2 
1 B G  6  1_555 B C  38 1_555 B U  7  1_555 B A  37 1_555 -0.967 -1.323 3.272 -5.386 4.552  30.357 -3.330 0.777  3.165 8.548  
10.114  31.146 1  BB_G-33U-32:A-2C-1_BB    B -33 ? B -1  ? B -32 ? B -2  ? 
1 B U  7  1_555 B A  37 1_555 B U  8  1_555 B A  36 1_555 0.364  -1.071 3.173 0.725  6.601  33.045 -2.859 -0.517 2.918 11.461 
-1.258  33.687 2  BB_U-32U-31:A-3A-2_BB    B -32 ? B -2  ? B -31 ? B -3  ? 
1 B U  8  1_555 B A  36 1_555 B G  9  1_555 B C  35 1_555 -0.816 -1.820 2.905 -4.158 16.152 25.725 -5.864 0.925  1.616 32.311 
8.318   30.582 3  BB_U-31G-30:C-4A-3_BB    B -31 ? B -3  ? B -30 ? B -4  ? 
1 B G  9  1_555 B C  35 1_555 B U  10 1_555 B A  34 1_555 0.546  -1.348 3.462 -0.148 6.127  28.263 -4.082 -1.127 3.104 12.363 
0.298   28.907 4  BB_G-30U-29:A-5C-4_BB    B -30 ? B -4  ? B -29 ? B -5  ? 
1 B A  11 1_555 B U  31 1_555 B A  13 1_555 B U  30 1_555 -0.343 -1.338 3.044 -2.369 8.382  36.435 -3.066 0.257  2.697 13.174 
3.723   37.428 5  BB_A-28A-26:U-9U-8_BB    B -28 ? B -8  ? B -26 ? B -9  ? 
1 B A  13 1_555 B U  30 1_555 B U  14 1_555 B A  29 1_555 -0.932 -2.392 3.213 -2.016 7.614  33.825 -5.075 1.281  2.677 12.871 
3.408   34.704 6  BB_A-26U-25:A-10U-9_BB   B -26 ? B -9  ? B -25 ? B -10 ? 
1 B U  14 1_555 B A  29 1_555 B A  15 1_555 B U  28 1_555 -0.266 -1.518 2.841 -5.427 26.197 30.752 -4.300 -0.053 1.252 41.016 
8.497   40.547 7  BB_U-25A-24:U-11A-10_BB  B -25 ? B -10 ? B -24 ? B -11 ? 
1 B A  15 1_555 B U  28 1_555 B U  16 1_555 B G  27 1_555 -0.191 -1.086 3.368 1.941  3.405  42.414 -1.844 0.463  3.264 4.695  
-2.676  42.587 8  BB_A-24U-23:G-12U-11_BB  B -24 ? B -11 ? B -23 ? B -12 ? 
1 B U  16 1_555 B G  27 1_555 B C  18 1_555 B G  26 1_555 -0.694 -1.909 3.029 7.259  4.923  38.314 -3.352 1.787  2.604 7.383  
-10.887 39.268 9  BB_U-23C-21:G-13G-12_BB  B -23 ? B -12 ? B -21 ? B -13 ? 
1 B C  18 1_555 B G  26 1_555 B U  19 1_555 B A  25 1_555 -0.273 -1.857 3.385 1.593  2.436  26.523 -4.664 1.010  3.183 5.288  
-3.458  26.679 10 BB_C-21U-20:A-14G-13_BB  B -21 ? B -13 ? B -20 ? B -14 ? 
1 B G  39 1_555 D DC 30 1_555 B G  40 1_555 D DC 29 1_555 -0.487 0.266  3.534 -6.335 1.304  29.392 0.218  -0.486 3.566 2.532  
12.298  30.080 11 BB_G0G1:DC19DC20_DD      B 0   ? D 20  ? B 1   ? D 19  ? 
1 B G  40 1_555 D DC 29 1_555 B A  41 1_555 D DT 28 1_555 -0.362 -0.316 3.220 -4.075 8.466  32.531 -1.883 -0.022 3.065 14.733 
7.092   33.826 12 BB_G1A2:DT18DC19_DD      B 1   ? D 19  ? B 2   ? D 18  ? 
1 B A  41 1_555 D DT 28 1_555 B G  42 1_555 D DC 27 1_555 0.541  -0.851 3.272 0.693  6.832  29.488 -2.976 -0.901 3.015 13.197 
-1.338  30.260 13 BB_A2G3:DC17DT18_DD      B 2   ? D 18  ? B 3   ? D 17  ? 
1 B G  42 1_555 D DC 27 1_555 B A  43 1_555 D DT 26 1_555 0.274  -1.064 3.371 2.242  7.230  29.725 -3.433 -0.079 3.046 13.813 
-4.283  30.653 14 BB_G3A4:DT16DC17_DD      B 3   ? D 17  ? B 4   ? D 16  ? 
1 B A  43 1_555 D DT 26 1_555 B U  44 1_555 D DA 25 1_555 0.074  -1.062 3.324 1.571  2.818  31.684 -2.451 0.152  3.220 5.146  
-2.867  31.844 15 BB_A4U5:DA15DT16_DD      B 4   ? D 16  ? B 5   ? D 15  ? 
1 B U  44 1_555 D DA 25 1_555 B G  45 1_555 D DC 24 1_555 0.316  -1.119 3.428 3.002  10.902 32.422 -3.611 -0.064 2.927 18.825 
-5.183  34.287 16 BB_U5G6:DC14DA15_DD      B 5   ? D 15  ? B 6   ? D 14  ? 
1 B G  45 1_555 D DC 24 1_555 B A  46 1_555 D DT 23 1_555 -0.429 -1.063 3.369 1.105  1.650  34.547 -2.047 0.895  3.302 2.775  
-1.858  34.602 17 BB_G6A7:DT13DC14_DD      B 6   ? D 14  ? B 7   ? D 13  ? 
1 B A  46 1_555 D DT 23 1_555 B G  47 1_555 D DC 22 1_555 0.578  -1.172 2.995 -4.905 4.299  30.446 -2.906 -1.901 2.685 8.070  
9.207   31.120 18 BB_A7G8:DC12DT13_DD      B 7   ? D 13  ? B 8   ? D 12  ? 
1 B G  47 1_555 D DC 22 1_555 B G  48 1_555 D DC 21 1_555 0.254  -1.458 3.321 0.426  3.651  30.903 -3.410 -0.392 3.135 6.822  
-0.796  31.116 19 BB_G8G9:DC11DC12_DD      B 8   ? D 12  ? B 9   ? D 11  ? 
1 B G  48 1_555 D DC 21 1_555 B U  49 1_555 D DA 20 1_555 0.587  -1.528 3.453 0.347  -0.421 38.475 -2.263 -0.845 3.474 -0.640 
-0.527  38.478 20 BB_G9U10:DA10DC11_DD     B 9   ? D 11  ? B 10  ? D 10  ? 
1 B U  49 1_555 D DA 20 1_555 B G  50 1_555 D DC 19 1_555 -1.381 -1.757 2.960 3.552  14.150 22.475 -6.467 3.656  1.396 32.297 
-8.107  26.744 21 BB_U10G11:DC9DA10_DD     B 10  ? D 10  ? B 11  ? D 9   ? 
1 B G  50 1_555 D DC 19 1_555 B C  51 1_555 D DG 18 1_555 -0.046 -1.065 3.241 -0.795 3.773  33.670 -2.418 -0.046 3.107 6.487  
1.368   33.883 22 BB_G11C12:DG8DC9_DD      B 11  ? D 9   ? B 12  ? D 8   ? 
1 B C  51 1_555 D DG 18 1_555 B G  52 1_555 D DC 17 1_555 -0.159 -1.471 3.036 -1.364 21.762 26.713 -5.149 0.102  1.466 39.742 
2.491   34.356 23 BB_C12G13:DC7DG8_DD      B 12  ? D 8   ? B 13  ? D 7   ? 
1 B G  52 1_555 D DC 17 1_555 B C  53 1_555 D DG 16 1_555 -0.537 -1.045 3.227 -4.558 3.944  34.116 -2.351 0.215  3.134 6.658  
7.695   34.629 24 BB_G13C14:DG6DC7_DD      B 13  ? D 7   ? B 14  ? D 6   ? 
1 B C  53 1_555 D DG 16 1_555 B G  54 1_555 D DC 15 1_555 0.239  -2.084 3.099 2.121  20.222 27.742 -5.933 -0.155 1.330 36.596 
-3.839  34.277 25 BB_C14G15:DC5DG6_DD      B 14  ? D 6   ? B 15  ? D 5   ? 
1 B G  54 1_555 D DC 15 1_555 B U  55 1_555 D DA 14 1_555 0.482  -1.843 3.424 1.801  2.406  29.600 -4.109 -0.551 3.290 4.694  
-3.514  29.749 26 BB_G15U16:DA4DC5_DD      B 15  ? D 5   ? B 16  ? D 4   ? 
1 C DT 1  1_555 D DA 40 1_555 C DG 2  1_555 D DC 39 1_555 -0.312 1.112  3.563 -0.278 0.304  37.876 1.671  0.443  3.574 0.468  
0.428   37.878 27 CC_DT-10DG-9:DC29DA30_DD C -10 ? D 30  ? C -9  ? D 29  ? 
1 C DG 2  1_555 D DC 39 1_555 C DT 3  1_555 D DA 38 1_555 -0.301 0.181  3.095 -4.736 3.302  28.203 -0.344 -0.411 3.104 6.688  
9.592   28.777 28 CC_DG-9DT-8:DA28DC29_DD  C -9  ? D 29  ? C -8  ? D 28  ? 
1 C DT 3  1_555 D DA 38 1_555 C DC 4  1_555 D DG 37 1_555 0.407  0.028  3.265 0.143  3.105  39.234 -0.326 -0.587 3.259 4.616  
-0.213  39.352 29 CC_DT-8DC-7:DG27DA28_DD  C -8  ? D 28  ? C -7  ? D 27  ? 
1 C DC 4  1_555 D DG 37 1_555 C DT 5  1_555 D DA 36 1_555 -0.232 -0.689 3.374 0.266  -0.326 33.901 -1.127 0.441  3.379 -0.560 
-0.457  33.904 30 CC_DC-7DT-6:DA26DG27_DD  C -7  ? D 27  ? C -6  ? D 26  ? 
1 C DT 5  1_555 D DA 36 1_555 C DA 6  1_555 D DT 35 1_555 -0.005 -0.331 3.455 -0.137 -2.144 39.994 -0.224 -0.009 3.468 -3.131 
0.200   40.049 31 CC_DT-6DA-5:DT25DA26_DD  C -6  ? D 26  ? C -5  ? D 25  ? 
1 C DA 6  1_555 D DT 35 1_555 C DT 7  1_555 D DA 34 1_555 -0.360 -0.727 3.333 -0.746 -2.644 34.052 -0.807 0.492  3.385 -4.506 
1.271   34.160 32 CC_DA-5DT-4:DA24DT25_DD  C -5  ? D 25  ? C -4  ? D 24  ? 
1 C DT 7  1_555 D DA 34 1_555 C DT 8  1_555 D DA 33 1_555 -0.299 -0.532 3.284 -0.750 0.538  34.571 -0.978 0.388  3.282 0.906  
1.261   34.583 33 CC_DT-4DT-3:DA23DA24_DD  C -4  ? D 24  ? C -3  ? D 23  ? 
1 C DT 8  1_555 D DA 33 1_555 C DT 9  1_555 D DA 32 1_555 0.309  0.343  3.279 0.111  3.092  33.634 0.087  -0.513 3.298 5.329  
-0.191  33.772 34 CC_DT-3DT-2:DA22DA23_DD  C -3  ? D 23  ? C -2  ? D 22  ? 
1 C DT 9  1_555 D DA 32 1_555 C DA 10 1_555 D DT 31 1_555 0.157  0.065  3.384 -2.535 1.736  28.493 -0.274 -0.908 3.355 3.515  
5.131   28.655 35 CC_DT-2DA-1:DT21DA22_DD  C -2  ? D 22  ? C -1  ? D 21  ? 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Japan Agency for Medical Research and Development (AMED)' Japan ? 1 
'Japan Society for the Promotion of Science (JSPS)'        Japan ? 2 
# 
_atom_sites.entry_id                    9IZP 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
MG 
N  
O  
P  
S  
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N     . MET A 1 11  ? 135.389 137.035 136.972 1.00 59.05  ? 1   MET A N     1 
ATOM   2    C  CA    . MET A 1 11  ? 136.123 137.659 135.881 1.00 50.34  ? 1   MET A CA    1 
ATOM   3    C  C     . MET A 1 11  ? 137.577 137.220 135.888 1.00 46.72  ? 1   MET A C     1 
ATOM   4    O  O     . MET A 1 11  ? 137.880 136.044 136.066 1.00 48.47  ? 1   MET A O     1 
ATOM   5    C  CB    . MET A 1 11  ? 136.033 139.181 135.978 1.00 49.89  ? 1   MET A CB    1 
ATOM   6    C  CG    . MET A 1 11  ? 134.981 139.798 135.078 1.00 59.06  ? 1   MET A CG    1 
ATOM   7    S  SD    . MET A 1 11  ? 135.284 139.470 133.332 1.00 84.28  ? 1   MET A SD    1 
ATOM   8    C  CE    . MET A 1 11  ? 136.879 140.252 133.106 1.00 46.29  ? 1   MET A CE    1 
ATOM   9    N  N     . LYS A 1 12  ? 138.475 138.180 135.698 1.00 42.67  ? 2   LYS A N     1 
ATOM   10   C  CA    . LYS A 1 12  ? 139.895 137.878 135.660 1.00 36.81  ? 2   LYS A CA    1 
ATOM   11   C  C     . LYS A 1 12  ? 140.425 137.565 137.053 1.00 35.58  ? 2   LYS A C     1 
ATOM   12   O  O     . LYS A 1 12  ? 139.883 138.008 138.067 1.00 35.94  ? 2   LYS A O     1 
ATOM   13   C  CB    . LYS A 1 12  ? 140.670 139.046 135.058 1.00 29.88  ? 2   LYS A CB    1 
ATOM   14   C  CG    . LYS A 1 12  ? 140.728 139.025 133.553 1.00 29.63  ? 2   LYS A CG    1 
ATOM   15   C  CD    . LYS A 1 12  ? 141.815 138.098 133.081 1.00 29.86  ? 2   LYS A CD    1 
ATOM   16   C  CE    . LYS A 1 12  ? 141.674 137.778 131.608 1.00 35.06  ? 2   LYS A CE    1 
ATOM   17   N  NZ    . LYS A 1 12  ? 142.778 136.894 131.136 1.00 39.89  ? 2   LYS A NZ    1 
ATOM   18   N  N     . LYS A 1 13  ? 141.496 136.776 137.086 1.00 34.72  ? 3   LYS A N     1 
ATOM   19   C  CA    . LYS A 1 13  ? 142.177 136.413 138.317 1.00 29.75  ? 3   LYS A CA    1 
ATOM   20   C  C     . LYS A 1 13  ? 143.658 136.271 138.015 1.00 28.40  ? 3   LYS A C     1 
ATOM   21   O  O     . LYS A 1 13  ? 144.064 136.147 136.860 1.00 28.95  ? 3   LYS A O     1 
ATOM   22   C  CB    . LYS A 1 13  ? 141.628 135.116 138.918 1.00 38.73  ? 3   LYS A CB    1 
ATOM   23   C  CG    . LYS A 1 13  ? 140.392 135.307 139.764 1.00 43.11  ? 3   LYS A CG    1 
ATOM   24   C  CD    . LYS A 1 13  ? 140.222 134.191 140.769 1.00 45.17  ? 3   LYS A CD    1 
ATOM   25   C  CE    . LYS A 1 13  ? 139.238 134.598 141.852 1.00 46.81  ? 3   LYS A CE    1 
ATOM   26   N  NZ    . LYS A 1 13  ? 139.253 133.651 142.995 1.00 57.26  ? 3   LYS A NZ    1 
ATOM   27   N  N     . SER A 1 14  ? 144.463 136.301 139.068 1.00 30.39  ? 4   SER A N     1 
ATOM   28   C  CA    . SER A 1 14  ? 145.907 136.215 138.948 1.00 26.73  ? 4   SER A CA    1 
ATOM   29   C  C     . SER A 1 14  ? 146.429 135.064 139.790 1.00 28.04  ? 4   SER A C     1 
ATOM   30   O  O     . SER A 1 14  ? 145.800 134.648 140.765 1.00 29.79  ? 4   SER A O     1 
ATOM   31   C  CB    . SER A 1 14  ? 146.593 137.514 139.389 1.00 25.60  ? 4   SER A CB    1 
ATOM   32   O  OG    . SER A 1 14  ? 146.354 138.563 138.473 1.00 30.13  ? 4   SER A OG    1 
ATOM   33   N  N     . ILE A 1 15  ? 147.579 134.541 139.387 1.00 22.42  ? 5   ILE A N     1 
ATOM   34   C  CA    . ILE A 1 15  ? 148.341 133.628 140.224 1.00 16.15  ? 5   ILE A CA    1 
ATOM   35   C  C     . ILE A 1 15  ? 149.812 133.860 139.942 1.00 15.53  ? 5   ILE A C     1 
ATOM   36   O  O     . ILE A 1 15  ? 150.213 134.057 138.794 1.00 19.11  ? 5   ILE A O     1 
ATOM   37   C  CB    . ILE A 1 15  ? 147.938 132.154 140.006 1.00 20.58  ? 5   ILE A CB    1 
ATOM   38   C  CG1   . ILE A 1 15  ? 148.801 131.265 140.892 1.00 20.16  ? 5   ILE A CG1   1 
ATOM   39   C  CG2   . ILE A 1 15  ? 148.038 131.760 138.538 1.00 17.76  ? 5   ILE A CG2   1 
ATOM   40   C  CD1   . ILE A 1 15  ? 148.420 129.861 140.901 1.00 18.22  ? 5   ILE A CD1   1 
ATOM   41   N  N     . LYS A 1 16  ? 150.610 133.858 141.001 1.00 15.33  ? 6   LYS A N     1 
ATOM   42   C  CA    . LYS A 1 16  ? 152.032 134.142 140.922 1.00 14.82  ? 6   LYS A CA    1 
ATOM   43   C  C     . LYS A 1 16  ? 152.824 132.859 141.130 1.00 14.46  ? 6   LYS A C     1 
ATOM   44   O  O     . LYS A 1 16  ? 152.497 132.049 142.001 1.00 14.48  ? 6   LYS A O     1 
ATOM   45   C  CB    . LYS A 1 16  ? 152.429 135.192 141.957 1.00 14.54  ? 6   LYS A CB    1 
ATOM   46   C  CG    . LYS A 1 16  ? 153.826 135.730 141.800 1.00 19.61  ? 6   LYS A CG    1 
ATOM   47   C  CD    . LYS A 1 16  ? 154.112 136.795 142.834 1.00 19.99  ? 6   LYS A CD    1 
ATOM   48   C  CE    . LYS A 1 16  ? 153.044 137.869 142.808 1.00 26.04  ? 6   LYS A CE    1 
ATOM   49   N  NZ    . LYS A 1 16  ? 153.245 138.898 143.856 1.00 31.41  ? 6   LYS A NZ    1 
ATOM   50   N  N     . PHE A 1 17  ? 153.851 132.676 140.310 1.00 15.91  ? 7   PHE A N     1 
ATOM   51   C  CA    . PHE A 1 17  ? 154.728 131.520 140.361 1.00 15.50  ? 7   PHE A CA    1 
ATOM   52   C  C     . PHE A 1 17  ? 156.143 131.987 140.648 1.00 20.49  ? 7   PHE A C     1 
ATOM   53   O  O     . PHE A 1 17  ? 156.503 133.127 140.363 1.00 25.93  ? 7   PHE A O     1 
ATOM   54   C  CB    . PHE A 1 17  ? 154.698 130.739 139.044 1.00 15.39  ? 7   PHE A CB    1 
ATOM   55   C  CG    . PHE A 1 17  ? 153.414 130.009 138.803 1.00 19.56  ? 7   PHE A CG    1 
ATOM   56   C  CD1   . PHE A 1 17  ? 153.175 128.787 139.399 1.00 19.33  ? 7   PHE A CD1   1 
ATOM   57   C  CD2   . PHE A 1 17  ? 152.442 130.547 137.987 1.00 19.12  ? 7   PHE A CD2   1 
ATOM   58   C  CE1   . PHE A 1 17  ? 152.001 128.121 139.182 1.00 18.55  ? 7   PHE A CE1   1 
ATOM   59   C  CE2   . PHE A 1 17  ? 151.267 129.881 137.769 1.00 17.63  ? 7   PHE A CE2   1 
ATOM   60   C  CZ    . PHE A 1 17  ? 151.045 128.668 138.366 1.00 19.31  ? 7   PHE A CZ    1 
ATOM   61   N  N     . LYS A 1 18  ? 156.947 131.101 141.220 1.00 19.62  ? 8   LYS A N     1 
ATOM   62   C  CA    . LYS A 1 18  ? 158.364 131.361 141.428 1.00 19.22  ? 8   LYS A CA    1 
ATOM   63   C  C     . LYS A 1 18  ? 159.171 130.526 140.448 1.00 20.35  ? 8   LYS A C     1 
ATOM   64   O  O     . LYS A 1 18  ? 158.931 129.325 140.307 1.00 24.18  ? 8   LYS A O     1 
ATOM   65   C  CB    . LYS A 1 18  ? 158.786 131.050 142.865 1.00 23.97  ? 8   LYS A CB    1 
ATOM   66   C  CG    . LYS A 1 18  ? 160.206 131.488 143.175 1.00 24.68  ? 8   LYS A CG    1 
ATOM   67   C  CD    . LYS A 1 18  ? 160.470 131.615 144.660 1.00 32.03  ? 8   LYS A CD    1 
ATOM   68   C  CE    . LYS A 1 18  ? 160.418 130.280 145.361 1.00 32.69  ? 8   LYS A CE    1 
ATOM   69   N  NZ    . LYS A 1 18  ? 160.789 130.413 146.790 1.00 25.92  ? 8   LYS A NZ    1 
ATOM   70   N  N     . VAL A 1 19  ? 160.121 131.163 139.764 1.00 24.63  ? 9   VAL A N     1 
ATOM   71   C  CA    . VAL A 1 19  ? 160.965 130.420 138.841 1.00 30.04  ? 9   VAL A CA    1 
ATOM   72   C  C     . VAL A 1 19  ? 161.976 129.606 139.636 1.00 26.00  ? 9   VAL A C     1 
ATOM   73   O  O     . VAL A 1 19  ? 162.434 130.012 140.711 1.00 28.28  ? 9   VAL A O     1 
ATOM   74   C  CB    . VAL A 1 19  ? 161.673 131.350 137.837 1.00 26.34  ? 9   VAL A CB    1 
ATOM   75   C  CG1   . VAL A 1 19  ? 160.658 132.121 137.031 1.00 25.44  ? 9   VAL A CG1   1 
ATOM   76   C  CG2   . VAL A 1 19  ? 162.646 132.270 138.528 1.00 31.52  ? 9   VAL A CG2   1 
ATOM   77   N  N     . LYS A 1 20  ? 162.316 128.435 139.112 1.00 25.92  ? 10  LYS A N     1 
ATOM   78   C  CA    . LYS A 1 20  ? 163.275 127.542 139.743 1.00 26.75  ? 10  LYS A CA    1 
ATOM   79   C  C     . LYS A 1 20  ? 164.510 127.476 138.862 1.00 33.96  ? 10  LYS A C     1 
ATOM   80   O  O     . LYS A 1 20  ? 164.419 127.113 137.687 1.00 42.25  ? 10  LYS A O     1 
ATOM   81   C  CB    . LYS A 1 20  ? 162.680 126.150 139.951 1.00 31.92  ? 10  LYS A CB    1 
ATOM   82   C  CG    . LYS A 1 20  ? 163.673 125.137 140.474 1.00 31.56  ? 10  LYS A CG    1 
ATOM   83   C  CD    . LYS A 1 20  ? 163.021 123.801 140.714 1.00 33.30  ? 10  LYS A CD    1 
ATOM   84   C  CE    . LYS A 1 20  ? 164.048 122.759 141.079 1.00 36.75  ? 10  LYS A CE    1 
ATOM   85   N  NZ    . LYS A 1 20  ? 165.073 122.620 140.017 1.00 39.88  ? 10  LYS A NZ    1 
ATOM   86   N  N     . GLY A 1 21  ? 165.651 127.824 139.424 1.00 42.02  ? 11  GLY A N     1 
ATOM   87   C  CA    . GLY A 1 21  ? 166.888 127.851 138.686 1.00 44.70  ? 11  GLY A CA    1 
ATOM   88   C  C     . GLY A 1 21  ? 167.277 129.257 138.283 1.00 52.51  ? 11  GLY A C     1 
ATOM   89   O  O     . GLY A 1 21  ? 166.844 130.253 138.868 1.00 46.65  ? 11  GLY A O     1 
ATOM   90   N  N     . ASN A 1 22  ? 168.110 129.333 137.251 1.00 56.51  ? 12  ASN A N     1 
ATOM   91   C  CA    . ASN A 1 22  ? 168.639 130.595 136.756 1.00 55.24  ? 12  ASN A CA    1 
ATOM   92   C  C     . ASN A 1 22  ? 167.946 130.950 135.450 1.00 50.94  ? 12  ASN A C     1 
ATOM   93   O  O     . ASN A 1 22  ? 167.981 130.173 134.491 1.00 51.47  ? 12  ASN A O     1 
ATOM   94   C  CB    . ASN A 1 22  ? 170.152 130.513 136.566 1.00 57.02  ? 12  ASN A CB    1 
ATOM   95   C  CG    . ASN A 1 22  ? 170.907 130.659 137.871 1.00 60.58  ? 12  ASN A CG    1 
ATOM   96   O  OD1   . ASN A 1 22  ? 170.632 131.562 138.661 1.00 52.99  ? 12  ASN A OD1   1 
ATOM   97   N  ND2   . ASN A 1 22  ? 171.860 129.766 138.107 1.00 58.53  ? 12  ASN A ND2   1 
ATOM   98   N  N     . CYS A 1 23  ? 167.327 132.121 135.418 1.00 45.76  ? 13  CYS A N     1 
ATOM   99   C  CA    . CYS A 1 23  ? 166.594 132.673 134.297 1.00 46.93  ? 13  CYS A CA    1 
ATOM   100  C  C     . CYS A 1 23  ? 167.311 133.905 133.758 1.00 49.74  ? 13  CYS A C     1 
ATOM   101  O  O     . CYS A 1 23  ? 167.875 134.679 134.539 1.00 51.11  ? 13  CYS A O     1 
ATOM   102  C  CB    . CYS A 1 23  ? 165.171 133.051 134.728 1.00 46.22  ? 13  CYS A CB    1 
ATOM   103  S  SG    . CYS A 1 23  ? 164.121 133.777 133.458 1.00 59.37  ? 13  CYS A SG    1 
ATOM   104  N  N     . PRO A 1 24  ? 167.327 134.110 132.440 1.00 46.25  ? 14  PRO A N     1 
ATOM   105  C  CA    . PRO A 1 24  ? 168.004 135.298 131.897 1.00 42.84  ? 14  PRO A CA    1 
ATOM   106  C  C     . PRO A 1 24  ? 167.366 136.604 132.317 1.00 40.96  ? 14  PRO A C     1 
ATOM   107  O  O     . PRO A 1 24  ? 168.007 137.654 132.200 1.00 48.30  ? 14  PRO A O     1 
ATOM   108  C  CB    . PRO A 1 24  ? 167.916 135.093 130.379 1.00 47.77  ? 14  PRO A CB    1 
ATOM   109  C  CG    . PRO A 1 24  ? 166.812 134.120 130.180 1.00 48.20  ? 14  PRO A CG    1 
ATOM   110  C  CD    . PRO A 1 24  ? 166.827 133.227 131.375 1.00 46.49  ? 14  PRO A CD    1 
ATOM   111  N  N     . ILE A 1 25  ? 166.126 136.583 132.800 1.00 41.38  ? 15  ILE A N     1 
ATOM   112  C  CA    . ILE A 1 25  ? 165.433 137.803 133.205 1.00 40.65  ? 15  ILE A CA    1 
ATOM   113  C  C     . ILE A 1 25  ? 165.994 138.228 134.558 1.00 43.16  ? 15  ILE A C     1 
ATOM   114  O  O     . ILE A 1 25  ? 165.620 137.694 135.603 1.00 43.26  ? 15  ILE A O     1 
ATOM   115  C  CB    . ILE A 1 25  ? 163.917 137.612 133.247 1.00 34.14  ? 15  ILE A CB    1 
ATOM   116  C  CG1   . ILE A 1 25  ? 163.412 137.300 131.842 1.00 32.83  ? 15  ILE A CG1   1 
ATOM   117  C  CG2   . ILE A 1 25  ? 163.238 138.854 133.778 1.00 32.80  ? 15  ILE A CG2   1 
ATOM   118  C  CD1   . ILE A 1 25  ? 162.001 136.858 131.787 1.00 27.96  ? 15  ILE A CD1   1 
ATOM   119  N  N     . THR A 1 26  ? 166.903 139.192 134.534 1.00 42.54  ? 16  THR A N     1 
ATOM   120  C  CA    . THR A 1 26  ? 167.521 139.759 135.719 1.00 42.83  ? 16  THR A CA    1 
ATOM   121  C  C     . THR A 1 26  ? 166.957 141.154 135.960 1.00 43.79  ? 16  THR A C     1 
ATOM   122  O  O     . THR A 1 26  ? 166.032 141.601 135.282 1.00 50.14  ? 16  THR A O     1 
ATOM   123  C  CB    . THR A 1 26  ? 169.044 139.792 135.569 1.00 47.28  ? 16  THR A CB    1 
ATOM   124  O  OG1   . THR A 1 26  ? 169.405 140.659 134.489 1.00 51.91  ? 16  THR A OG1   1 
ATOM   125  C  CG2   . THR A 1 26  ? 169.578 138.406 135.285 1.00 41.63  ? 16  THR A CG2   1 
ATOM   126  N  N     . LYS A 1 27  ? 167.526 141.845 136.948 1.00 42.00  ? 17  LYS A N     1 
ATOM   127  C  CA    . LYS A 1 27  ? 167.084 143.203 137.239 1.00 42.65  ? 17  LYS A CA    1 
ATOM   128  C  C     . LYS A 1 27  ? 167.482 144.179 136.139 1.00 49.09  ? 17  LYS A C     1 
ATOM   129  O  O     . LYS A 1 27  ? 166.867 145.240 136.010 1.00 53.39  ? 17  LYS A O     1 
ATOM   130  C  CB    . LYS A 1 27  ? 167.643 143.665 138.584 1.00 46.00  ? 17  LYS A CB    1 
ATOM   131  C  CG    . LYS A 1 27  ? 167.473 142.651 139.697 1.00 53.94  ? 17  LYS A CG    1 
ATOM   132  C  CD    . LYS A 1 27  ? 167.780 143.248 141.057 1.00 51.20  ? 17  LYS A CD    1 
ATOM   133  C  CE    . LYS A 1 27  ? 166.844 144.398 141.380 1.00 51.52  ? 17  LYS A CE    1 
ATOM   134  N  NZ    . LYS A 1 27  ? 166.979 144.846 142.791 1.00 52.80  ? 17  LYS A NZ    1 
ATOM   135  N  N     . ASP A 1 28  ? 168.502 143.849 135.343 1.00 50.79  ? 18  ASP A N     1 
ATOM   136  C  CA    . ASP A 1 28  ? 168.906 144.737 134.256 1.00 50.70  ? 18  ASP A CA    1 
ATOM   137  C  C     . ASP A 1 28  ? 167.875 144.767 133.136 1.00 49.04  ? 18  ASP A C     1 
ATOM   138  O  O     . ASP A 1 28  ? 167.640 145.826 132.538 1.00 54.81  ? 18  ASP A O     1 
ATOM   139  C  CB    . ASP A 1 28  ? 170.269 144.319 133.711 1.00 57.62  ? 18  ASP A CB    1 
ATOM   140  C  CG    . ASP A 1 28  ? 170.825 145.313 132.713 1.00 70.05  ? 18  ASP A CG    1 
ATOM   141  O  OD1   . ASP A 1 28  ? 170.477 146.508 132.813 1.00 73.26  ? 18  ASP A OD1   1 
ATOM   142  O  OD2   . ASP A 1 28  ? 171.617 144.905 131.837 1.00 68.35  ? 18  ASP A OD2   1 
ATOM   143  N  N     . VAL A 1 29  ? 167.251 143.626 132.843 1.00 44.46  ? 19  VAL A N     1 
ATOM   144  C  CA    . VAL A 1 29  ? 166.164 143.587 131.870 1.00 44.53  ? 19  VAL A CA    1 
ATOM   145  C  C     . VAL A 1 29  ? 165.044 144.525 132.299 1.00 40.24  ? 19  VAL A C     1 
ATOM   146  O  O     . VAL A 1 29  ? 164.530 145.325 131.505 1.00 41.33  ? 19  VAL A O     1 
ATOM   147  C  CB    . VAL A 1 29  ? 165.655 142.143 131.712 1.00 43.83  ? 19  VAL A CB    1 
ATOM   148  C  CG1   . VAL A 1 29  ? 164.613 142.054 130.618 1.00 37.72  ? 19  VAL A CG1   1 
ATOM   149  C  CG2   . VAL A 1 29  ? 166.808 141.200 131.441 1.00 41.84  ? 19  VAL A CG2   1 
ATOM   150  N  N     . ILE A 1 30  ? 164.671 144.452 133.574 1.00 37.75  ? 20  ILE A N     1 
ATOM   151  C  CA    . ILE A 1 30  ? 163.587 145.272 134.091 1.00 38.77  ? 20  ILE A CA    1 
ATOM   152  C  C     . ILE A 1 30  ? 163.987 146.742 134.119 1.00 44.74  ? 20  ILE A C     1 
ATOM   153  O  O     . ILE A 1 30  ? 163.163 147.626 133.862 1.00 52.49  ? 20  ILE A O     1 
ATOM   154  C  CB    . ILE A 1 30  ? 163.166 144.756 135.475 1.00 34.83  ? 20  ILE A CB    1 
ATOM   155  C  CG1   . ILE A 1 30  ? 162.894 143.256 135.396 1.00 28.59  ? 20  ILE A CG1   1 
ATOM   156  C  CG2   . ILE A 1 30  ? 161.945 145.490 135.955 1.00 39.93  ? 20  ILE A CG2   1 
ATOM   157  C  CD1   . ILE A 1 30  ? 162.486 142.639 136.699 1.00 29.11  ? 20  ILE A CD1   1 
ATOM   158  N  N     . ASN A 1 31  ? 165.251 147.031 134.427 1.00 41.98  ? 21  ASN A N     1 
ATOM   159  C  CA    . ASN A 1 31  ? 165.707 148.416 134.396 1.00 42.45  ? 21  ASN A CA    1 
ATOM   160  C  C     . ASN A 1 31  ? 165.614 148.995 132.993 1.00 42.97  ? 21  ASN A C     1 
ATOM   161  O  O     . ASN A 1 31  ? 165.199 150.146 132.817 1.00 42.23  ? 21  ASN A O     1 
ATOM   162  C  CB    . ASN A 1 31  ? 167.138 148.518 134.920 1.00 45.75  ? 21  ASN A CB    1 
ATOM   163  C  CG    . ASN A 1 31  ? 167.224 148.320 136.416 1.00 51.36  ? 21  ASN A CG    1 
ATOM   164  O  OD1   . ASN A 1 31  ? 166.244 147.956 137.061 1.00 49.95  ? 21  ASN A OD1   1 
ATOM   165  N  ND2   . ASN A 1 31  ? 168.400 148.565 136.978 1.00 56.59  ? 21  ASN A ND2   1 
ATOM   166  N  N     . GLU A 1 32  ? 166.009 148.220 131.982 1.00 45.29  ? 22  GLU A N     1 
ATOM   167  C  CA    . GLU A 1 32  ? 165.883 148.685 130.603 1.00 41.17  ? 22  GLU A CA    1 
ATOM   168  C  C     . GLU A 1 32  ? 164.425 148.938 130.244 1.00 38.87  ? 22  GLU A C     1 
ATOM   169  O  O     . GLU A 1 32  ? 164.090 149.961 129.626 1.00 44.79  ? 22  GLU A O     1 
ATOM   170  C  CB    . GLU A 1 32  ? 166.502 147.658 129.658 1.00 38.21  ? 22  GLU A CB    1 
ATOM   171  C  CG    . GLU A 1 32  ? 167.059 148.229 128.370 1.00 48.54  ? 22  GLU A CG    1 
ATOM   172  C  CD    . GLU A 1 32  ? 167.678 147.161 127.494 1.00 54.94  ? 22  GLU A CD    1 
ATOM   173  O  OE1   . GLU A 1 32  ? 167.538 145.968 127.829 1.00 51.42  ? 22  GLU A OE1   1 
ATOM   174  O  OE2   . GLU A 1 32  ? 168.302 147.508 126.470 1.00 55.82  ? 22  GLU A OE2   1 
ATOM   175  N  N     . TYR A 1 33  ? 163.543 148.017 130.640 1.00 38.27  ? 23  TYR A N     1 
ATOM   176  C  CA    . TYR A 1 33  ? 162.109 148.200 130.436 1.00 35.99  ? 23  TYR A CA    1 
ATOM   177  C  C     . TYR A 1 33  ? 161.632 149.519 131.030 1.00 37.23  ? 23  TYR A C     1 
ATOM   178  O  O     . TYR A 1 33  ? 160.920 150.293 130.379 1.00 37.82  ? 23  TYR A O     1 
ATOM   179  C  CB    . TYR A 1 33  ? 161.366 147.022 131.063 1.00 31.70  ? 23  TYR A CB    1 
ATOM   180  C  CG    . TYR A 1 33  ? 159.873 146.971 130.843 1.00 26.99  ? 23  TYR A CG    1 
ATOM   181  C  CD1   . TYR A 1 33  ? 159.003 147.651 131.684 1.00 25.56  ? 23  TYR A CD1   1 
ATOM   182  C  CD2   . TYR A 1 33  ? 159.331 146.199 129.830 1.00 25.57  ? 23  TYR A CD2   1 
ATOM   183  C  CE1   . TYR A 1 33  ? 157.644 147.588 131.503 1.00 20.70  ? 23  TYR A CE1   1 
ATOM   184  C  CE2   . TYR A 1 33  ? 157.974 146.129 129.644 1.00 26.75  ? 23  TYR A CE2   1 
ATOM   185  C  CZ    . TYR A 1 33  ? 157.134 146.826 130.484 1.00 25.87  ? 23  TYR A CZ    1 
ATOM   186  O  OH    . TYR A 1 33  ? 155.777 146.757 130.299 1.00 25.26  ? 23  TYR A OH    1 
ATOM   187  N  N     . LYS A 1 34  ? 162.036 149.797 132.270 1.00 35.77  ? 24  LYS A N     1 
ATOM   188  C  CA    . LYS A 1 34  ? 161.553 150.987 132.962 1.00 37.12  ? 24  LYS A CA    1 
ATOM   189  C  C     . LYS A 1 34  ? 162.134 152.264 132.365 1.00 39.55  ? 24  LYS A C     1 
ATOM   190  O  O     . LYS A 1 34  ? 161.455 153.297 132.317 1.00 42.12  ? 24  LYS A O     1 
ATOM   191  C  CB    . LYS A 1 34  ? 161.879 150.887 134.446 1.00 35.41  ? 24  LYS A CB    1 
ATOM   192  C  CG    . LYS A 1 34  ? 161.169 149.749 135.158 1.00 37.01  ? 24  LYS A CG    1 
ATOM   193  C  CD    . LYS A 1 34  ? 161.705 149.577 136.567 1.00 42.91  ? 24  LYS A CD    1 
ATOM   194  C  CE    . LYS A 1 34  ? 162.072 150.917 137.187 1.00 40.62  ? 24  LYS A CE    1 
ATOM   195  N  NZ    . LYS A 1 34  ? 162.815 150.747 138.460 1.00 42.15  ? 24  LYS A NZ    1 
ATOM   196  N  N     . GLU A 1 35  ? 163.387 152.222 131.912 1.00 40.38  ? 25  GLU A N     1 
ATOM   197  C  CA    . GLU A 1 35  ? 163.957 153.391 131.251 1.00 42.05  ? 25  GLU A CA    1 
ATOM   198  C  C     . GLU A 1 35  ? 163.195 153.722 129.978 1.00 43.30  ? 25  GLU A C     1 
ATOM   199  O  O     . GLU A 1 35  ? 162.908 154.895 129.700 1.00 46.93  ? 25  GLU A O     1 
ATOM   200  C  CB    . GLU A 1 35  ? 165.436 153.164 130.946 1.00 44.33  ? 25  GLU A CB    1 
ATOM   201  C  CG    . GLU A 1 35  ? 166.313 153.060 132.177 1.00 45.68  ? 25  GLU A CG    1 
ATOM   202  C  CD    . GLU A 1 35  ? 167.653 152.416 131.884 1.00 57.65  ? 25  GLU A CD    1 
ATOM   203  O  OE1   . GLU A 1 35  ? 167.810 151.838 130.788 1.00 55.11  ? 25  GLU A OE1   1 
ATOM   204  O  OE2   . GLU A 1 35  ? 168.551 152.486 132.750 1.00 59.99  ? 25  GLU A OE2   1 
ATOM   205  N  N     . TYR A 1 36  ? 162.852 152.700 129.189 1.00 38.12  ? 26  TYR A N     1 
ATOM   206  C  CA    . TYR A 1 36  ? 162.058 152.958 127.991 1.00 35.88  ? 26  TYR A CA    1 
ATOM   207  C  C     . TYR A 1 36  ? 160.676 153.492 128.350 1.00 33.44  ? 26  TYR A C     1 
ATOM   208  O  O     . TYR A 1 36  ? 160.160 154.400 127.685 1.00 39.24  ? 26  TYR A O     1 
ATOM   209  C  CB    . TYR A 1 36  ? 161.955 151.695 127.145 1.00 37.93  ? 26  TYR A CB    1 
ATOM   210  C  CG    . TYR A 1 36  ? 163.238 151.365 126.436 1.00 41.29  ? 26  TYR A CG    1 
ATOM   211  C  CD1   . TYR A 1 36  ? 163.888 152.317 125.672 1.00 44.56  ? 26  TYR A CD1   1 
ATOM   212  C  CD2   . TYR A 1 36  ? 163.803 150.103 126.530 1.00 41.90  ? 26  TYR A CD2   1 
ATOM   213  C  CE1   . TYR A 1 36  ? 165.064 152.024 125.021 1.00 49.37  ? 26  TYR A CE1   1 
ATOM   214  C  CE2   . TYR A 1 36  ? 164.979 149.801 125.883 1.00 40.81  ? 26  TYR A CE2   1 
ATOM   215  C  CZ    . TYR A 1 36  ? 165.605 150.766 125.130 1.00 46.75  ? 26  TYR A CZ    1 
ATOM   216  O  OH    . TYR A 1 36  ? 166.778 150.474 124.482 1.00 50.19  ? 26  TYR A OH    1 
ATOM   217  N  N     . TYR A 1 37  ? 160.067 152.944 129.405 1.00 34.65  ? 27  TYR A N     1 
ATOM   218  C  CA    . TYR A 1 37  ? 158.789 153.466 129.879 1.00 34.33  ? 27  TYR A CA    1 
ATOM   219  C  C     . TYR A 1 37  ? 158.884 154.955 130.169 1.00 35.69  ? 27  TYR A C     1 
ATOM   220  O  O     . TYR A 1 37  ? 158.041 155.745 129.728 1.00 43.38  ? 27  TYR A O     1 
ATOM   221  C  CB    . TYR A 1 37  ? 158.337 152.718 131.135 1.00 29.16  ? 27  TYR A CB    1 
ATOM   222  C  CG    . TYR A 1 37  ? 156.999 153.189 131.670 1.00 29.21  ? 27  TYR A CG    1 
ATOM   223  C  CD1   . TYR A 1 37  ? 156.899 154.322 132.461 1.00 32.35  ? 27  TYR A CD1   1 
ATOM   224  C  CD2   . TYR A 1 37  ? 155.837 152.498 131.385 1.00 29.98  ? 27  TYR A CD2   1 
ATOM   225  C  CE1   . TYR A 1 37  ? 155.691 154.755 132.935 1.00 29.45  ? 27  TYR A CE1   1 
ATOM   226  C  CE2   . TYR A 1 37  ? 154.626 152.923 131.863 1.00 30.97  ? 27  TYR A CE2   1 
ATOM   227  C  CZ    . TYR A 1 37  ? 154.559 154.052 132.635 1.00 30.31  ? 27  TYR A CZ    1 
ATOM   228  O  OH    . TYR A 1 37  ? 153.346 154.479 133.114 1.00 36.56  ? 27  TYR A OH    1 
ATOM   229  N  N     . ASN A 1 38  ? 159.908 155.355 130.919 1.00 31.80  ? 28  ASN A N     1 
ATOM   230  C  CA    . ASN A 1 38  ? 160.009 156.749 131.332 1.00 35.52  ? 28  ASN A CA    1 
ATOM   231  C  C     . ASN A 1 38  ? 160.304 157.671 130.152 1.00 38.72  ? 28  ASN A C     1 
ATOM   232  O  O     . ASN A 1 38  ? 159.765 158.779 130.089 1.00 42.48  ? 28  ASN A O     1 
ATOM   233  C  CB    . ASN A 1 38  ? 161.058 156.899 132.430 1.00 40.84  ? 28  ASN A CB    1 
ATOM   234  C  CG    . ASN A 1 38  ? 160.485 156.651 133.811 1.00 39.67  ? 28  ASN A CG    1 
ATOM   235  O  OD1   . ASN A 1 38  ? 159.312 156.911 134.061 1.00 38.97  ? 28  ASN A OD1   1 
ATOM   236  N  ND2   . ASN A 1 38  ? 161.311 156.141 134.714 1.00 37.09  ? 28  ASN A ND2   1 
ATOM   237  N  N     . LYS A 1 39  ? 161.146 157.244 129.204 1.00 38.32  ? 29  LYS A N     1 
ATOM   238  C  CA    . LYS A 1 39  ? 161.386 158.079 128.024 1.00 35.36  ? 29  LYS A CA    1 
ATOM   239  C  C     . LYS A 1 39  ? 160.104 158.287 127.221 1.00 37.32  ? 29  LYS A C     1 
ATOM   240  O  O     . LYS A 1 39  ? 159.784 159.414 126.802 1.00 44.74  ? 29  LYS A O     1 
ATOM   241  C  CB    . LYS A 1 39  ? 162.461 157.462 127.130 1.00 41.53  ? 29  LYS A CB    1 
ATOM   242  C  CG    . LYS A 1 39  ? 163.793 157.190 127.790 1.00 45.39  ? 29  LYS A CG    1 
ATOM   243  C  CD    . LYS A 1 39  ? 164.741 156.534 126.799 1.00 53.88  ? 29  LYS A CD    1 
ATOM   244  C  CE    . LYS A 1 39  ? 165.880 155.812 127.497 1.00 57.60  ? 29  LYS A CE    1 
ATOM   245  N  NZ    . LYS A 1 39  ? 166.618 154.914 126.563 1.00 55.41  ? 29  LYS A NZ    1 
ATOM   246  N  N     . CYS A 1 40  ? 159.357 157.203 126.988 1.00 34.75  ? 30  CYS A N     1 
ATOM   247  C  CA    . CYS A 1 40  ? 158.109 157.326 126.243 1.00 39.05  ? 30  CYS A CA    1 
ATOM   248  C  C     . CYS A 1 40  ? 157.140 158.248 126.963 1.00 40.17  ? 30  CYS A C     1 
ATOM   249  O  O     . CYS A 1 40  ? 156.504 159.106 126.338 1.00 43.12  ? 30  CYS A O     1 
ATOM   250  C  CB    . CYS A 1 40  ? 157.482 155.947 126.037 1.00 39.15  ? 30  CYS A CB    1 
ATOM   251  S  SG    . CYS A 1 40  ? 156.203 155.877 124.776 1.00 43.04  ? 30  CYS A SG    1 
ATOM   252  N  N     . SER A 1 41  ? 157.029 158.098 128.282 1.00 35.76  ? 31  SER A N     1 
ATOM   253  C  CA    . SER A 1 41  ? 156.114 158.938 129.037 1.00 30.52  ? 31  SER A CA    1 
ATOM   254  C  C     . SER A 1 41  ? 156.557 160.393 129.033 1.00 35.67  ? 31  SER A C     1 
ATOM   255  O  O     . SER A 1 41  ? 155.710 161.290 129.033 1.00 43.93  ? 31  SER A O     1 
ATOM   256  C  CB    . SER A 1 41  ? 155.989 158.411 130.461 1.00 31.49  ? 31  SER A CB    1 
ATOM   257  O  OG    . SER A 1 41  ? 155.625 157.045 130.443 1.00 35.14  ? 31  SER A OG    1 
ATOM   258  N  N     . ASP A 1 42  ? 157.865 160.649 129.017 1.00 35.49  ? 32  ASP A N     1 
ATOM   259  C  CA    . ASP A 1 42  ? 158.347 162.023 128.934 1.00 36.33  ? 32  ASP A CA    1 
ATOM   260  C  C     . ASP A 1 42  ? 157.913 162.676 127.629 1.00 41.35  ? 32  ASP A C     1 
ATOM   261  O  O     . ASP A 1 42  ? 157.415 163.810 127.624 1.00 44.43  ? 32  ASP A O     1 
ATOM   262  C  CB    . ASP A 1 42  ? 159.867 162.057 129.069 1.00 38.13  ? 32  ASP A CB    1 
ATOM   263  C  CG    . ASP A 1 42  ? 160.330 161.795 130.486 1.00 50.39  ? 32  ASP A CG    1 
ATOM   264  O  OD1   . ASP A 1 42  ? 159.495 161.384 131.319 1.00 52.50  ? 32  ASP A OD1   1 
ATOM   265  O  OD2   . ASP A 1 42  ? 161.530 162.000 130.770 1.00 51.31  ? 32  ASP A OD2   1 
ATOM   266  N  N     . TRP A 1 43  ? 158.085 161.971 126.506 1.00 40.24  ? 33  TRP A N     1 
ATOM   267  C  CA    . TRP A 1 43  ? 157.638 162.542 125.235 1.00 37.03  ? 33  TRP A CA    1 
ATOM   268  C  C     . TRP A 1 43  ? 156.129 162.762 125.234 1.00 42.57  ? 33  TRP A C     1 
ATOM   269  O  O     . TRP A 1 43  ? 155.642 163.829 124.827 1.00 47.59  ? 33  TRP A O     1 
ATOM   270  C  CB    . TRP A 1 43  ? 158.040 161.655 124.058 1.00 43.97  ? 33  TRP A CB    1 
ATOM   271  C  CG    . TRP A 1 43  ? 157.765 162.312 122.727 1.00 47.70  ? 33  TRP A CG    1 
ATOM   272  C  CD1   . TRP A 1 43  ? 158.641 163.037 121.977 1.00 52.79  ? 33  TRP A CD1   1 
ATOM   273  C  CD2   . TRP A 1 43  ? 156.524 162.321 122.009 1.00 42.81  ? 33  TRP A CD2   1 
ATOM   274  N  NE1   . TRP A 1 43  ? 158.027 163.490 120.836 1.00 49.82  ? 33  TRP A NE1   1 
ATOM   275  C  CE2   . TRP A 1 43  ? 156.726 163.064 120.834 1.00 46.33  ? 33  TRP A CE2   1 
ATOM   276  C  CE3   . TRP A 1 43  ? 155.263 161.771 122.245 1.00 42.19  ? 33  TRP A CE3   1 
ATOM   277  C  CZ2   . TRP A 1 43  ? 155.719 163.266 119.900 1.00 47.79  ? 33  TRP A CZ2   1 
ATOM   278  C  CZ3   . TRP A 1 43  ? 154.266 161.975 121.317 1.00 42.17  ? 33  TRP A CZ3   1 
ATOM   279  C  CH2   . TRP A 1 43  ? 154.498 162.713 120.160 1.00 42.63  ? 33  TRP A CH2   1 
ATOM   280  N  N     . ILE A 1 44  ? 155.371 161.764 125.696 1.00 40.94  ? 34  ILE A N     1 
ATOM   281  C  CA    . ILE A 1 44  ? 153.916 161.884 125.693 1.00 36.77  ? 34  ILE A CA    1 
ATOM   282  C  C     . ILE A 1 44  ? 153.484 163.082 126.523 1.00 38.95  ? 34  ILE A C     1 
ATOM   283  O  O     . ILE A 1 44  ? 152.622 163.864 126.106 1.00 43.77  ? 34  ILE A O     1 
ATOM   284  C  CB    . ILE A 1 44  ? 153.258 160.584 126.193 1.00 36.29  ? 34  ILE A CB    1 
ATOM   285  C  CG1   . ILE A 1 44  ? 153.640 159.404 125.303 1.00 39.52  ? 34  ILE A CG1   1 
ATOM   286  C  CG2   . ILE A 1 44  ? 151.749 160.724 126.215 1.00 36.42  ? 34  ILE A CG2   1 
ATOM   287  C  CD1   . ILE A 1 44  ? 153.085 159.487 123.910 1.00 47.15  ? 34  ILE A CD1   1 
ATOM   288  N  N     . LYS A 1 45  ? 154.083 163.256 127.701 1.00 35.18  ? 35  LYS A N     1 
ATOM   289  C  CA    . LYS A 1 45  ? 153.743 164.393 128.546 1.00 37.05  ? 35  LYS A CA    1 
ATOM   290  C  C     . LYS A 1 45  ? 154.062 165.707 127.852 1.00 43.12  ? 35  LYS A C     1 
ATOM   291  O  O     . LYS A 1 45  ? 153.233 166.624 127.826 1.00 45.69  ? 35  LYS A O     1 
ATOM   292  C  CB    . LYS A 1 45  ? 154.489 164.298 129.873 1.00 40.84  ? 35  LYS A CB    1 
ATOM   293  C  CG    . LYS A 1 45  ? 154.783 165.632 130.518 1.00 41.42  ? 35  LYS A CG    1 
ATOM   294  C  CD    . LYS A 1 45  ? 155.970 165.532 131.446 1.00 42.76  ? 35  LYS A CD    1 
ATOM   295  C  CE    . LYS A 1 45  ? 156.464 166.903 131.864 1.00 48.79  ? 35  LYS A CE    1 
ATOM   296  N  NZ    . LYS A 1 45  ? 157.491 166.809 132.935 1.00 44.50  ? 35  LYS A NZ    1 
ATOM   297  N  N     . ASN A 1 46  ? 155.256 165.815 127.267 1.00 42.49  ? 36  ASN A N     1 
ATOM   298  C  CA    . ASN A 1 46  ? 155.644 167.087 126.673 1.00 39.15  ? 36  ASN A CA    1 
ATOM   299  C  C     . ASN A 1 46  ? 154.868 167.421 125.408 1.00 42.01  ? 36  ASN A C     1 
ATOM   300  O  O     . ASN A 1 46  ? 154.924 168.570 124.962 1.00 42.59  ? 36  ASN A O     1 
ATOM   301  C  CB    . ASN A 1 46  ? 157.139 167.102 126.377 1.00 36.36  ? 36  ASN A CB    1 
ATOM   302  C  CG    . ASN A 1 46  ? 157.966 167.253 127.624 1.00 47.49  ? 36  ASN A CG    1 
ATOM   303  O  OD1   . ASN A 1 46  ? 157.434 167.286 128.732 1.00 47.44  ? 36  ASN A OD1   1 
ATOM   304  N  ND2   . ASN A 1 46  ? 159.277 167.355 127.456 1.00 50.98  ? 36  ASN A ND2   1 
ATOM   305  N  N     . ASN A 1 47  ? 154.144 166.468 124.820 1.00 41.41  ? 37  ASN A N     1 
ATOM   306  C  CA    . ASN A 1 47  ? 153.365 166.771 123.623 1.00 39.06  ? 37  ASN A CA    1 
ATOM   307  C  C     . ASN A 1 47  ? 151.863 166.572 123.808 1.00 37.76  ? 37  ASN A C     1 
ATOM   308  O  O     . ASN A 1 47  ? 151.144 166.421 122.818 1.00 37.87  ? 37  ASN A O     1 
ATOM   309  C  CB    . ASN A 1 47  ? 153.873 165.941 122.446 1.00 43.34  ? 37  ASN A CB    1 
ATOM   310  C  CG    . ASN A 1 47  ? 155.146 166.496 121.858 1.00 45.55  ? 37  ASN A CG    1 
ATOM   311  O  OD1   . ASN A 1 47  ? 155.114 167.391 121.020 1.00 53.59  ? 37  ASN A OD1   1 
ATOM   312  N  ND2   . ASN A 1 47  ? 156.279 165.989 122.318 1.00 40.99  ? 37  ASN A ND2   1 
ATOM   313  N  N     . LEU A 1 48  ? 151.361 166.593 125.047 1.00 38.23  ? 38  LEU A N     1 
ATOM   314  C  CA    . LEU A 1 48  ? 149.934 166.358 125.269 1.00 37.07  ? 38  LEU A CA    1 
ATOM   315  C  C     . LEU A 1 48  ? 149.057 167.429 124.641 1.00 32.34  ? 38  LEU A C     1 
ATOM   316  O  O     . LEU A 1 48  ? 147.858 167.202 124.462 1.00 30.57  ? 38  LEU A O     1 
ATOM   317  C  CB    . LEU A 1 48  ? 149.616 166.275 126.763 1.00 34.75  ? 38  LEU A CB    1 
ATOM   318  C  CG    . LEU A 1 48  ? 149.793 164.935 127.473 1.00 31.51  ? 38  LEU A CG    1 
ATOM   319  C  CD1   . LEU A 1 48  ? 149.528 165.102 128.952 1.00 32.08  ? 38  LEU A CD1   1 
ATOM   320  C  CD2   . LEU A 1 48  ? 148.872 163.896 126.879 1.00 26.71  ? 38  LEU A CD2   1 
ATOM   321  N  N     . THR A 1 49  ? 149.622 168.593 124.333 1.00 38.80  ? 39  THR A N     1 
ATOM   322  C  CA    . THR A 1 49  ? 148.878 169.685 123.722 1.00 45.13  ? 39  THR A CA    1 
ATOM   323  C  C     . THR A 1 49  ? 149.617 170.357 122.574 1.00 44.82  ? 39  THR A C     1 
ATOM   324  O  O     . THR A 1 49  ? 149.007 171.165 121.869 1.00 43.91  ? 39  THR A O     1 
ATOM   325  C  CB    . THR A 1 49  ? 148.530 170.744 124.779 1.00 41.79  ? 39  THR A CB    1 
ATOM   326  O  OG1   . THR A 1 49  ? 149.694 171.030 125.565 1.00 41.96  ? 39  THR A OG1   1 
ATOM   327  C  CG2   . THR A 1 49  ? 147.422 170.251 125.693 1.00 40.32  ? 39  THR A CG2   1 
ATOM   328  N  N     . SER A 1 50  ? 150.894 170.050 122.353 1.00 42.38  ? 40  SER A N     1 
ATOM   329  C  CA    . SER A 1 50  ? 151.686 170.695 121.316 1.00 49.41  ? 40  SER A CA    1 
ATOM   330  C  C     . SER A 1 50  ? 151.480 170.097 119.929 1.00 52.75  ? 40  SER A C     1 
ATOM   331  O  O     . SER A 1 50  ? 151.907 170.710 118.945 1.00 58.00  ? 40  SER A O     1 
ATOM   332  C  CB    . SER A 1 50  ? 153.169 170.627 121.682 1.00 52.44  ? 40  SER A CB    1 
ATOM   333  O  OG    . SER A 1 50  ? 153.975 171.100 120.619 1.00 62.96  ? 40  SER A OG    1 
ATOM   334  N  N     . ILE A 1 51  ? 150.862 168.923 119.817 1.00 48.88  ? 41  ILE A N     1 
ATOM   335  C  CA    . ILE A 1 51  ? 150.556 168.311 118.529 1.00 51.28  ? 41  ILE A CA    1 
ATOM   336  C  C     . ILE A 1 51  ? 149.120 167.815 118.559 1.00 45.87  ? 41  ILE A C     1 
ATOM   337  O  O     . ILE A 1 51  ? 148.660 167.285 119.575 1.00 44.42  ? 41  ILE A O     1 
ATOM   338  C  CB    . ILE A 1 51  ? 151.508 167.144 118.184 1.00 52.52  ? 41  ILE A CB    1 
ATOM   339  C  CG1   . ILE A 1 51  ? 152.961 167.495 118.490 1.00 45.98  ? 41  ILE A CG1   1 
ATOM   340  C  CG2   . ILE A 1 51  ? 151.372 166.763 116.719 1.00 47.96  ? 41  ILE A CG2   1 
ATOM   341  C  CD1   . ILE A 1 51  ? 153.916 166.381 118.153 1.00 44.77  ? 41  ILE A CD1   1 
ATOM   342  N  N     . THR A 1 52  ? 148.414 167.984 117.448 1.00 41.80  ? 42  THR A N     1 
ATOM   343  C  CA    . THR A 1 52  ? 147.064 167.465 117.302 1.00 42.23  ? 42  THR A CA    1 
ATOM   344  C  C     . THR A 1 52  ? 147.085 166.146 116.539 1.00 41.14  ? 42  THR A C     1 
ATOM   345  O  O     . THR A 1 52  ? 148.062 165.795 115.877 1.00 46.19  ? 42  THR A O     1 
ATOM   346  C  CB    . THR A 1 52  ? 146.155 168.473 116.590 1.00 47.93  ? 42  THR A CB    1 
ATOM   347  O  OG1   . THR A 1 52  ? 146.501 168.552 115.203 1.00 51.05  ? 42  THR A OG1   1 
ATOM   348  C  CG2   . THR A 1 52  ? 146.294 169.848 117.217 1.00 47.74  ? 42  THR A CG2   1 
ATOM   349  N  N     . ILE A 1 53  ? 145.975 165.417 116.647 1.00 39.91  ? 43  ILE A N     1 
ATOM   350  C  CA    . ILE A 1 53  ? 145.876 164.082 116.066 1.00 40.87  ? 43  ILE A CA    1 
ATOM   351  C  C     . ILE A 1 53  ? 145.962 164.128 114.546 1.00 48.18  ? 43  ILE A C     1 
ATOM   352  O  O     . ILE A 1 53  ? 146.517 163.216 113.918 1.00 51.51  ? 43  ILE A O     1 
ATOM   353  C  CB    . ILE A 1 53  ? 144.575 163.421 116.547 1.00 35.09  ? 43  ILE A CB    1 
ATOM   354  C  CG1   . ILE A 1 53  ? 144.506 163.479 118.073 1.00 31.25  ? 43  ILE A CG1   1 
ATOM   355  C  CG2   . ILE A 1 53  ? 144.489 162.000 116.053 1.00 36.13  ? 43  ILE A CG2   1 
ATOM   356  C  CD1   . ILE A 1 53  ? 143.199 163.025 118.654 1.00 35.14  ? 43  ILE A CD1   1 
ATOM   357  N  N     . GLY A 1 54  ? 145.416 165.176 113.930 1.00 47.38  ? 44  GLY A N     1 
ATOM   358  C  CA    . GLY A 1 54  ? 145.440 165.267 112.481 1.00 42.39  ? 44  GLY A CA    1 
ATOM   359  C  C     . GLY A 1 54  ? 146.836 165.408 111.913 1.00 46.44  ? 44  GLY A C     1 
ATOM   360  O  O     . GLY A 1 54  ? 147.130 164.871 110.847 1.00 49.91  ? 44  GLY A O     1 
ATOM   361  N  N     . GLU A 1 55  ? 147.713 166.136 112.604 1.00 46.73  ? 45  GLU A N     1 
ATOM   362  C  CA    . GLU A 1 55  ? 149.094 166.225 112.141 1.00 46.38  ? 45  GLU A CA    1 
ATOM   363  C  C     . GLU A 1 55  ? 149.763 164.859 112.167 1.00 54.40  ? 45  GLU A C     1 
ATOM   364  O  O     . GLU A 1 55  ? 150.485 164.493 111.233 1.00 57.65  ? 45  GLU A O     1 
ATOM   365  C  CB    . GLU A 1 55  ? 149.883 167.216 112.992 1.00 45.35  ? 45  GLU A CB    1 
ATOM   366  C  CG    . GLU A 1 55  ? 149.126 168.467 113.373 1.00 50.12  ? 45  GLU A CG    1 
ATOM   367  C  CD    . GLU A 1 55  ? 149.812 169.232 114.483 1.00 56.59  ? 45  GLU A CD    1 
ATOM   368  O  OE1   . GLU A 1 55  ? 151.059 169.249 114.507 1.00 56.69  ? 45  GLU A OE1   1 
ATOM   369  O  OE2   . GLU A 1 55  ? 149.106 169.804 115.338 1.00 53.45  ? 45  GLU A OE2   1 
ATOM   370  N  N     . MET A 1 56  ? 149.519 164.084 113.227 1.00 51.90  ? 46  MET A N     1 
ATOM   371  C  CA    . MET A 1 56  ? 150.085 162.743 113.325 1.00 44.92  ? 46  MET A CA    1 
ATOM   372  C  C     . MET A 1 56  ? 149.576 161.850 112.203 1.00 45.83  ? 46  MET A C     1 
ATOM   373  O  O     . MET A 1 56  ? 150.359 161.177 111.520 1.00 54.10  ? 46  MET A O     1 
ATOM   374  C  CB    . MET A 1 56  ? 149.742 162.138 114.684 1.00 44.57  ? 46  MET A CB    1 
ATOM   375  C  CG    . MET A 1 56  ? 150.467 162.781 115.845 1.00 45.62  ? 46  MET A CG    1 
ATOM   376  S  SD    . MET A 1 56  ? 150.420 161.795 117.348 1.00 40.01  ? 46  MET A SD    1 
ATOM   377  C  CE    . MET A 1 56  ? 151.242 162.909 118.481 1.00 42.47  ? 46  MET A CE    1 
ATOM   378  N  N     . ALA A 1 57  ? 148.258 161.835 111.998 1.00 41.74  ? 47  ALA A N     1 
ATOM   379  C  CA    . ALA A 1 57  ? 147.683 160.981 110.966 1.00 44.43  ? 47  ALA A CA    1 
ATOM   380  C  C     . ALA A 1 57  ? 148.135 161.413 109.577 1.00 47.05  ? 47  ALA A C     1 
ATOM   381  O  O     . ALA A 1 57  ? 148.377 160.571 108.706 1.00 49.67  ? 47  ALA A O     1 
ATOM   382  C  CB    . ALA A 1 57  ? 146.162 160.993 111.070 1.00 47.95  ? 47  ALA A CB    1 
ATOM   383  N  N     . LYS A 1 58  ? 148.257 162.723 109.354 1.00 52.99  ? 48  LYS A N     1 
ATOM   384  C  CA    . LYS A 1 58  ? 148.733 163.231 108.074 1.00 58.18  ? 48  LYS A CA    1 
ATOM   385  C  C     . LYS A 1 58  ? 150.176 162.826 107.826 1.00 54.82  ? 48  LYS A C     1 
ATOM   386  O  O     . LYS A 1 58  ? 150.537 162.446 106.707 1.00 59.35  ? 48  LYS A O     1 
ATOM   387  C  CB    . LYS A 1 58  ? 148.584 164.751 108.044 1.00 59.80  ? 48  LYS A CB    1 
ATOM   388  C  CG    . LYS A 1 58  ? 148.879 165.403 106.711 1.00 59.64  ? 48  LYS A CG    1 
ATOM   389  C  CD    . LYS A 1 58  ? 148.487 166.870 106.752 1.00 66.27  ? 48  LYS A CD    1 
ATOM   390  C  CE    . LYS A 1 58  ? 148.622 167.527 105.392 1.00 64.43  ? 48  LYS A CE    1 
ATOM   391  N  NZ    . LYS A 1 58  ? 148.017 168.885 105.396 1.00 67.15  ? 48  LYS A NZ    1 
ATOM   392  N  N     . PHE A 1 59  ? 151.019 162.897 108.856 1.00 46.27  ? 49  PHE A N     1 
ATOM   393  C  CA    . PHE A 1 59  ? 152.399 162.457 108.697 1.00 49.75  ? 49  PHE A CA    1 
ATOM   394  C  C     . PHE A 1 59  ? 152.469 160.969 108.383 1.00 55.12  ? 49  PHE A C     1 
ATOM   395  O  O     . PHE A 1 59  ? 153.255 160.546 107.527 1.00 58.54  ? 49  PHE A O     1 
ATOM   396  C  CB    . PHE A 1 59  ? 153.204 162.776 109.953 1.00 53.20  ? 49  PHE A CB    1 
ATOM   397  C  CG    . PHE A 1 59  ? 154.553 162.129 109.982 1.00 57.26  ? 49  PHE A CG    1 
ATOM   398  C  CD1   . PHE A 1 59  ? 155.575 162.600 109.182 1.00 55.62  ? 49  PHE A CD1   1 
ATOM   399  C  CD2   . PHE A 1 59  ? 154.797 161.044 110.804 1.00 56.34  ? 49  PHE A CD2   1 
ATOM   400  C  CE1   . PHE A 1 59  ? 156.815 162.006 109.206 1.00 58.17  ? 49  PHE A CE1   1 
ATOM   401  C  CE2   . PHE A 1 59  ? 156.037 160.445 110.831 1.00 59.58  ? 49  PHE A CE2   1 
ATOM   402  C  CZ    . PHE A 1 59  ? 157.046 160.926 110.030 1.00 61.37  ? 49  PHE A CZ    1 
ATOM   403  N  N     . LEU A 1 60  ? 151.658 160.156 109.066 1.00 52.79  ? 50  LEU A N     1 
ATOM   404  C  CA    . LEU A 1 60  ? 151.676 158.720 108.794 1.00 47.85  ? 50  LEU A CA    1 
ATOM   405  C  C     . LEU A 1 60  ? 151.164 158.412 107.394 1.00 53.66  ? 50  LEU A C     1 
ATOM   406  O  O     . LEU A 1 60  ? 151.670 157.500 106.731 1.00 58.33  ? 50  LEU A O     1 
ATOM   407  C  CB    . LEU A 1 60  ? 150.863 157.963 109.841 1.00 41.07  ? 50  LEU A CB    1 
ATOM   408  C  CG    . LEU A 1 60  ? 151.555 157.754 111.186 1.00 40.08  ? 50  LEU A CG    1 
ATOM   409  C  CD1   . LEU A 1 60  ? 150.819 156.723 112.003 1.00 38.33  ? 50  LEU A CD1   1 
ATOM   410  C  CD2   . LEU A 1 60  ? 152.991 157.339 110.983 1.00 40.93  ? 50  LEU A CD2   1 
ATOM   411  N  N     . GLN A 1 61  ? 150.154 159.148 106.929 1.00 54.88  ? 51  GLN A N     1 
ATOM   412  C  CA    . GLN A 1 61  ? 149.684 158.971 105.559 1.00 54.26  ? 51  GLN A CA    1 
ATOM   413  C  C     . GLN A 1 61  ? 150.763 159.351 104.554 1.00 56.61  ? 51  GLN A C     1 
ATOM   414  O  O     . GLN A 1 61  ? 150.957 158.663 103.546 1.00 55.00  ? 51  GLN A O     1 
ATOM   415  C  CB    . GLN A 1 61  ? 148.428 159.805 105.324 1.00 48.31  ? 51  GLN A CB    1 
ATOM   416  C  CG    . GLN A 1 61  ? 147.573 159.330 104.171 1.00 52.83  ? 51  GLN A CG    1 
ATOM   417  C  CD    . GLN A 1 61  ? 146.299 160.131 104.034 1.00 58.31  ? 51  GLN A CD    1 
ATOM   418  O  OE1   . GLN A 1 61  ? 146.298 161.349 104.210 1.00 56.98  ? 51  GLN A OE1   1 
ATOM   419  N  NE2   . GLN A 1 61  ? 145.202 159.452 103.731 1.00 56.26  ? 51  GLN A NE2   1 
ATOM   420  N  N     . GLU A 1 62  ? 151.472 160.450 104.808 1.00 60.47  ? 52  GLU A N     1 
ATOM   421  C  CA    . GLU A 1 62  ? 152.488 160.908 103.871 1.00 63.38  ? 52  GLU A CA    1 
ATOM   422  C  C     . GLU A 1 62  ? 153.666 159.943 103.805 1.00 63.29  ? 52  GLU A C     1 
ATOM   423  O  O     . GLU A 1 62  ? 154.075 159.522 102.718 1.00 64.88  ? 52  GLU A O     1 
ATOM   424  C  CB    . GLU A 1 62  ? 152.958 162.307 104.265 1.00 65.54  ? 52  GLU A CB    1 
ATOM   425  C  CG    . GLU A 1 62  ? 154.237 162.755 103.589 1.00 70.69  ? 52  GLU A CG    1 
ATOM   426  C  CD    . GLU A 1 62  ? 154.702 164.111 104.084 1.00 84.29  ? 52  GLU A CD    1 
ATOM   427  O  OE1   . GLU A 1 62  ? 153.987 164.721 104.909 1.00 77.95  ? 52  GLU A OE1   1 
ATOM   428  O  OE2   . GLU A 1 62  ? 155.784 164.566 103.653 1.00 84.57  ? 52  GLU A OE2   1 
ATOM   429  N  N     . THR A 1 63  ? 154.221 159.571 104.959 1.00 61.48  ? 53  THR A N     1 
ATOM   430  C  CA    . THR A 1 63  ? 155.486 158.843 104.951 1.00 67.12  ? 53  THR A CA    1 
ATOM   431  C  C     . THR A 1 63  ? 155.312 157.359 104.649 1.00 68.89  ? 53  THR A C     1 
ATOM   432  O  O     . THR A 1 63  ? 156.258 156.718 104.179 1.00 68.41  ? 53  THR A O     1 
ATOM   433  C  CB    . THR A 1 63  ? 156.216 159.029 106.284 1.00 61.15  ? 53  THR A CB    1 
ATOM   434  O  OG1   . THR A 1 63  ? 157.549 158.517 106.173 1.00 65.30  ? 53  THR A OG1   1 
ATOM   435  C  CG2   . THR A 1 63  ? 155.500 158.300 107.399 1.00 60.69  ? 53  THR A CG2   1 
ATOM   436  N  N     . LEU A 1 64  ? 154.131 156.794 104.898 1.00 68.04  ? 54  LEU A N     1 
ATOM   437  C  CA    . LEU A 1 64  ? 153.899 155.377 104.659 1.00 62.58  ? 54  LEU A CA    1 
ATOM   438  C  C     . LEU A 1 64  ? 152.892 155.093 103.557 1.00 66.77  ? 54  LEU A C     1 
ATOM   439  O  O     . LEU A 1 64  ? 153.029 154.084 102.865 1.00 68.47  ? 54  LEU A O     1 
ATOM   440  C  CB    . LEU A 1 64  ? 153.433 154.690 105.947 1.00 59.42  ? 54  LEU A CB    1 
ATOM   441  C  CG    . LEU A 1 64  ? 154.298 154.934 107.185 1.00 60.17  ? 54  LEU A CG    1 
ATOM   442  C  CD1   . LEU A 1 64  ? 153.756 154.185 108.390 1.00 63.69  ? 54  LEU A CD1   1 
ATOM   443  C  CD2   . LEU A 1 64  ? 155.744 154.554 106.920 1.00 52.04  ? 54  LEU A CD2   1 
ATOM   444  N  N     . GLY A 1 65  ? 151.897 155.955 103.368 1.00 68.27  ? 55  GLY A N     1 
ATOM   445  C  CA    . GLY A 1 65  ? 150.930 155.775 102.301 1.00 70.02  ? 55  GLY A CA    1 
ATOM   446  C  C     . GLY A 1 65  ? 150.061 154.543 102.439 1.00 65.18  ? 55  GLY A C     1 
ATOM   447  O  O     . GLY A 1 65  ? 149.871 153.799 101.472 1.00 68.21  ? 55  GLY A O     1 
ATOM   448  N  N     . LYS A 1 66  ? 149.522 154.315 103.631 1.00 59.81  ? 56  LYS A N     1 
ATOM   449  C  CA    . LYS A 1 66  ? 148.700 153.149 103.909 1.00 61.72  ? 56  LYS A CA    1 
ATOM   450  C  C     . LYS A 1 66  ? 147.252 153.568 104.131 1.00 59.03  ? 56  LYS A C     1 
ATOM   451  O  O     . LYS A 1 66  ? 146.983 154.634 104.691 1.00 61.18  ? 56  LYS A O     1 
ATOM   452  C  CB    . LYS A 1 66  ? 149.229 152.396 105.130 1.00 61.89  ? 56  LYS A CB    1 
ATOM   453  C  CG    . LYS A 1 66  ? 150.704 152.041 105.029 1.00 66.93  ? 56  LYS A CG    1 
ATOM   454  C  CD    . LYS A 1 66  ? 151.301 151.704 106.385 1.00 66.62  ? 56  LYS A CD    1 
ATOM   455  C  CE    . LYS A 1 66  ? 152.718 151.181 106.235 1.00 61.37  ? 56  LYS A CE    1 
ATOM   456  N  NZ    . LYS A 1 66  ? 153.365 150.920 107.545 1.00 67.09  ? 56  LYS A NZ    1 
ATOM   457  N  N     . ASP A 1 67  ? 146.325 152.728 103.679 1.00 56.42  ? 57  ASP A N     1 
ATOM   458  C  CA    . ASP A 1 67  ? 144.891 152.966 103.823 1.00 56.75  ? 57  ASP A CA    1 
ATOM   459  C  C     . ASP A 1 67  ? 144.386 152.048 104.931 1.00 54.89  ? 57  ASP A C     1 
ATOM   460  O  O     . ASP A 1 67  ? 143.971 150.915 104.684 1.00 53.28  ? 57  ASP A O     1 
ATOM   461  C  CB    . ASP A 1 67  ? 144.153 152.724 102.510 1.00 54.43  ? 57  ASP A CB    1 
ATOM   462  C  CG    . ASP A 1 67  ? 142.657 152.974 102.622 1.00 60.13  ? 57  ASP A CG    1 
ATOM   463  O  OD1   . ASP A 1 67  ? 142.187 153.394 103.699 1.00 47.64  ? 57  ASP A OD1   1 
ATOM   464  O  OD2   . ASP A 1 67  ? 141.945 152.748 101.623 1.00 71.92  ? 57  ASP A OD2   1 
ATOM   465  N  N     . VAL A 1 68  ? 144.411 152.557 106.159 1.00 48.72  ? 58  VAL A N     1 
ATOM   466  C  CA    . VAL A 1 68  ? 143.995 151.819 107.340 1.00 45.85  ? 58  VAL A CA    1 
ATOM   467  C  C     . VAL A 1 68  ? 143.073 152.700 108.168 1.00 47.14  ? 58  VAL A C     1 
ATOM   468  O  O     . VAL A 1 68  ? 143.053 153.923 108.029 1.00 54.50  ? 58  VAL A O     1 
ATOM   469  C  CB    . VAL A 1 68  ? 145.200 151.357 108.180 1.00 47.30  ? 58  VAL A CB    1 
ATOM   470  C  CG1   . VAL A 1 68  ? 146.049 150.381 107.396 1.00 48.03  ? 58  VAL A CG1   1 
ATOM   471  C  CG2   . VAL A 1 68  ? 146.032 152.559 108.548 1.00 43.53  ? 58  VAL A CG2   1 
ATOM   472  N  N     . ALA A 1 69  ? 142.304 152.055 109.046 1.00 42.71  ? 59  ALA A N     1 
ATOM   473  C  CA    . ALA A 1 69  ? 141.320 152.779 109.840 1.00 40.55  ? 59  ALA A CA    1 
ATOM   474  C  C     . ALA A 1 69  ? 141.965 153.693 110.870 1.00 42.58  ? 59  ALA A C     1 
ATOM   475  O  O     . ALA A 1 69  ? 141.358 154.693 111.259 1.00 47.97  ? 59  ALA A O     1 
ATOM   476  C  CB    . ALA A 1 69  ? 140.376 151.803 110.534 1.00 44.27  ? 59  ALA A CB    1 
ATOM   477  N  N     . TYR A 1 70  ? 143.176 153.383 111.334 1.00 38.48  ? 60  TYR A N     1 
ATOM   478  C  CA    . TYR A 1 70  ? 143.778 154.237 112.350 1.00 40.54  ? 60  TYR A CA    1 
ATOM   479  C  C     . TYR A 1 70  ? 144.338 155.525 111.771 1.00 41.22  ? 60  TYR A C     1 
ATOM   480  O  O     . TYR A 1 70  ? 144.801 156.378 112.533 1.00 44.56  ? 60  TYR A O     1 
ATOM   481  C  CB    . TYR A 1 70  ? 144.849 153.477 113.151 1.00 37.88  ? 60  TYR A CB    1 
ATOM   482  C  CG    . TYR A 1 70  ? 146.206 153.271 112.510 1.00 34.31  ? 60  TYR A CG    1 
ATOM   483  C  CD1   . TYR A 1 70  ? 147.181 154.253 112.562 1.00 36.13  ? 60  TYR A CD1   1 
ATOM   484  C  CD2   . TYR A 1 70  ? 146.536 152.063 111.919 1.00 37.40  ? 60  TYR A CD2   1 
ATOM   485  C  CE1   . TYR A 1 70  ? 148.423 154.057 111.997 1.00 34.39  ? 60  TYR A CE1   1 
ATOM   486  C  CE2   . TYR A 1 70  ? 147.776 151.858 111.358 1.00 35.61  ? 60  TYR A CE2   1 
ATOM   487  C  CZ    . TYR A 1 70  ? 148.714 152.858 111.397 1.00 31.97  ? 60  TYR A CZ    1 
ATOM   488  O  OH    . TYR A 1 70  ? 149.951 152.655 110.837 1.00 30.45  ? 60  TYR A OH    1 
ATOM   489  N  N     . ILE A 1 71  ? 144.305 155.683 110.451 1.00 39.57  ? 61  ILE A N     1 
ATOM   490  C  CA    . ILE A 1 71  ? 144.582 156.959 109.820 1.00 42.36  ? 61  ILE A CA    1 
ATOM   491  C  C     . ILE A 1 71  ? 143.314 157.617 109.284 1.00 44.78  ? 61  ILE A C     1 
ATOM   492  O  O     . ILE A 1 71  ? 143.211 158.849 109.305 1.00 45.83  ? 61  ILE A O     1 
ATOM   493  C  CB    . ILE A 1 71  ? 145.631 156.784 108.703 1.00 44.91  ? 61  ILE A CB    1 
ATOM   494  C  CG1   . ILE A 1 71  ? 146.924 156.228 109.299 1.00 42.44  ? 61  ILE A CG1   1 
ATOM   495  C  CG2   . ILE A 1 71  ? 145.904 158.090 107.993 1.00 44.30  ? 61  ILE A CG2   1 
ATOM   496  C  CD1   . ILE A 1 71  ? 148.047 156.109 108.315 1.00 41.60  ? 61  ILE A CD1   1 
ATOM   497  N  N     . SER A 1 72  ? 142.336 156.831 108.835 1.00 45.67  ? 62  SER A N     1 
ATOM   498  C  CA    . SER A 1 72  ? 141.027 157.362 108.484 1.00 49.63  ? 62  SER A CA    1 
ATOM   499  C  C     . SER A 1 72  ? 140.274 157.894 109.695 1.00 49.41  ? 62  SER A C     1 
ATOM   500  O  O     . SER A 1 72  ? 139.348 158.694 109.530 1.00 52.32  ? 62  SER A O     1 
ATOM   501  C  CB    . SER A 1 72  ? 140.201 156.279 107.792 1.00 50.75  ? 62  SER A CB    1 
ATOM   502  O  OG    . SER A 1 72  ? 138.836 156.648 107.712 1.00 56.56  ? 62  SER A OG    1 
ATOM   503  N  N     . MET A 1 73  ? 140.632 157.458 110.898 1.00 46.16  ? 63  MET A N     1 
ATOM   504  C  CA    . MET A 1 73  ? 140.055 157.975 112.129 1.00 48.15  ? 63  MET A CA    1 
ATOM   505  C  C     . MET A 1 73  ? 140.898 159.084 112.740 1.00 47.79  ? 63  MET A C     1 
ATOM   506  O  O     . MET A 1 73  ? 140.565 159.582 113.816 1.00 56.49  ? 63  MET A O     1 
ATOM   507  C  CB    . MET A 1 73  ? 139.866 156.836 113.139 1.00 51.04  ? 63  MET A CB    1 
ATOM   508  C  CG    . MET A 1 73  ? 138.885 157.142 114.259 1.00 55.44  ? 63  MET A CG    1 
ATOM   509  S  SD    . MET A 1 73  ? 138.227 155.681 115.071 1.00 68.44  ? 63  MET A SD    1 
ATOM   510  C  CE    . MET A 1 73  ? 137.281 156.447 116.379 1.00 49.09  ? 63  MET A CE    1 
ATOM   511  N  N     . GLY A 1 74  ? 141.977 159.485 112.082 1.00 47.11  ? 64  GLY A N     1 
ATOM   512  C  CA    . GLY A 1 74  ? 142.799 160.562 112.586 1.00 48.10  ? 64  GLY A CA    1 
ATOM   513  C  C     . GLY A 1 74  ? 142.808 161.751 111.654 1.00 48.98  ? 64  GLY A C     1 
ATOM   514  O  O     . GLY A 1 74  ? 143.458 162.764 111.926 1.00 51.33  ? 64  GLY A O     1 
ATOM   515  N  N     . LEU A 1 75  ? 142.098 161.627 110.534 1.00 49.55  ? 65  LEU A N     1 
ATOM   516  C  CA    . LEU A 1 75  ? 141.932 162.718 109.588 1.00 45.93  ? 65  LEU A CA    1 
ATOM   517  C  C     . LEU A 1 75  ? 140.479 163.126 109.429 1.00 50.95  ? 65  LEU A C     1 
ATOM   518  O  O     . LEU A 1 75  ? 140.186 164.027 108.636 1.00 57.45  ? 65  LEU A O     1 
ATOM   519  C  CB    . LEU A 1 75  ? 142.506 162.337 108.219 1.00 48.09  ? 65  LEU A CB    1 
ATOM   520  C  CG    . LEU A 1 75  ? 143.985 161.967 108.196 1.00 46.88  ? 65  LEU A CG    1 
ATOM   521  C  CD1   . LEU A 1 75  ? 144.334 161.294 106.884 1.00 44.26  ? 65  LEU A CD1   1 
ATOM   522  C  CD2   . LEU A 1 75  ? 144.846 163.194 108.423 1.00 47.12  ? 65  LEU A CD2   1 
ATOM   523  N  N     . SER A 1 76  ? 139.565 162.492 110.154 1.00 56.07  ? 66  SER A N     1 
ATOM   524  C  CA    . SER A 1 76  ? 138.164 162.864 110.096 1.00 59.55  ? 66  SER A CA    1 
ATOM   525  C  C     . SER A 1 76  ? 137.950 164.222 110.760 1.00 59.58  ? 66  SER A C     1 
ATOM   526  O  O     . SER A 1 76  ? 138.845 164.784 111.399 1.00 57.31  ? 66  SER A O     1 
ATOM   527  C  CB    . SER A 1 76  ? 137.301 161.789 110.756 1.00 55.22  ? 66  SER A CB    1 
ATOM   528  O  OG    . SER A 1 76  ? 137.572 161.695 112.140 1.00 54.70  ? 66  SER A OG    1 
ATOM   529  N  N     . ASP A 1 77  ? 136.741 164.760 110.589 1.00 55.11  ? 67  ASP A N     1 
ATOM   530  C  CA    . ASP A 1 77  ? 136.440 166.086 111.115 1.00 55.58  ? 67  ASP A CA    1 
ATOM   531  C  C     . ASP A 1 77  ? 136.478 166.135 112.633 1.00 56.48  ? 67  ASP A C     1 
ATOM   532  O  O     . ASP A 1 77  ? 136.718 167.207 113.197 1.00 56.74  ? 67  ASP A O     1 
ATOM   533  C  CB    . ASP A 1 77  ? 135.072 166.550 110.622 1.00 58.06  ? 67  ASP A CB    1 
ATOM   534  C  CG    . ASP A 1 77  ? 135.153 167.305 109.318 1.00 67.39  ? 67  ASP A CG    1 
ATOM   535  O  OD1   . ASP A 1 77  ? 136.273 167.690 108.924 1.00 71.16  ? 67  ASP A OD1   1 
ATOM   536  O  OD2   . ASP A 1 77  ? 134.097 167.512 108.687 1.00 71.04  ? 67  ASP A OD2   1 
ATOM   537  N  N     . GLU A 1 78  ? 136.251 165.008 113.305 1.00 53.39  ? 68  GLU A N     1 
ATOM   538  C  CA    . GLU A 1 78  ? 136.232 165.013 114.762 1.00 50.65  ? 68  GLU A CA    1 
ATOM   539  C  C     . GLU A 1 78  ? 137.610 165.311 115.340 1.00 53.10  ? 68  GLU A C     1 
ATOM   540  O  O     . GLU A 1 78  ? 137.755 166.185 116.200 1.00 53.65  ? 68  GLU A O     1 
ATOM   541  C  CB    . GLU A 1 78  ? 135.717 163.673 115.279 1.00 52.62  ? 68  GLU A CB    1 
ATOM   542  C  CG    . GLU A 1 78  ? 134.371 163.282 114.722 1.00 60.71  ? 68  GLU A CG    1 
ATOM   543  C  CD    . GLU A 1 78  ? 133.634 162.317 115.623 1.00 70.79  ? 68  GLU A CD    1 
ATOM   544  O  OE1   . GLU A 1 78  ? 134.153 162.012 116.716 1.00 64.35  ? 68  GLU A OE1   1 
ATOM   545  O  OE2   . GLU A 1 78  ? 132.533 161.868 115.240 1.00 75.74  ? 68  GLU A OE2   1 
ATOM   546  N  N     . TRP A 1 79  ? 138.638 164.608 114.867 1.00 53.58  ? 69  TRP A N     1 
ATOM   547  C  CA    . TRP A 1 79  ? 139.910 164.542 115.568 1.00 45.31  ? 69  TRP A CA    1 
ATOM   548  C  C     . TRP A 1 79  ? 141.064 165.221 114.848 1.00 46.94  ? 69  TRP A C     1 
ATOM   549  O  O     . TRP A 1 79  ? 142.141 165.348 115.439 1.00 46.64  ? 69  TRP A O     1 
ATOM   550  C  CB    . TRP A 1 79  ? 140.289 163.078 115.827 1.00 39.88  ? 69  TRP A CB    1 
ATOM   551  C  CG    . TRP A 1 79  ? 139.186 162.269 116.404 1.00 40.53  ? 69  TRP A CG    1 
ATOM   552  C  CD1   . TRP A 1 79  ? 138.472 161.295 115.777 1.00 46.62  ? 69  TRP A CD1   1 
ATOM   553  C  CD2   . TRP A 1 79  ? 138.668 162.353 117.734 1.00 42.94  ? 69  TRP A CD2   1 
ATOM   554  N  NE1   . TRP A 1 79  ? 137.537 160.768 116.631 1.00 47.04  ? 69  TRP A NE1   1 
ATOM   555  C  CE2   . TRP A 1 79  ? 137.636 161.403 117.840 1.00 46.71  ? 69  TRP A CE2   1 
ATOM   556  C  CE3   . TRP A 1 79  ? 138.974 163.140 118.846 1.00 40.36  ? 69  TRP A CE3   1 
ATOM   557  C  CZ2   . TRP A 1 79  ? 136.914 161.215 119.012 1.00 44.02  ? 69  TRP A CZ2   1 
ATOM   558  C  CZ3   . TRP A 1 79  ? 138.254 162.955 120.006 1.00 39.16  ? 69  TRP A CZ3   1 
ATOM   559  C  CH2   . TRP A 1 79  ? 137.237 162.001 120.082 1.00 38.01  ? 69  TRP A CH2   1 
ATOM   560  N  N     . LYS A 1 80  ? 140.875 165.675 113.608 1.00 49.33  ? 70  LYS A N     1 
ATOM   561  C  CA    . LYS A 1 80  ? 142.009 166.151 112.824 1.00 50.74  ? 70  LYS A CA    1 
ATOM   562  C  C     . LYS A 1 80  ? 142.675 167.378 113.432 1.00 52.95  ? 70  LYS A C     1 
ATOM   563  O  O     . LYS A 1 80  ? 143.789 167.726 113.031 1.00 54.67  ? 70  LYS A O     1 
ATOM   564  C  CB    . LYS A 1 80  ? 141.580 166.462 111.391 1.00 48.96  ? 70  LYS A CB    1 
ATOM   565  C  CG    . LYS A 1 80  ? 140.588 167.598 111.261 1.00 55.94  ? 70  LYS A CG    1 
ATOM   566  C  CD    . LYS A 1 80  ? 140.374 167.952 109.801 1.00 60.24  ? 70  LYS A CD    1 
ATOM   567  C  CE    . LYS A 1 80  ? 139.437 169.134 109.646 1.00 61.00  ? 70  LYS A CE    1 
ATOM   568  N  NZ    . LYS A 1 80  ? 139.248 169.498 108.216 1.00 63.27  ? 70  LYS A NZ    1 
ATOM   569  N  N     . ASP A 1 81  ? 142.024 168.052 114.375 1.00 54.50  ? 71  ASP A N     1 
ATOM   570  C  CA    . ASP A 1 81  ? 142.595 169.244 114.977 1.00 50.18  ? 71  ASP A CA    1 
ATOM   571  C  C     . ASP A 1 81  ? 142.488 169.286 116.495 1.00 49.00  ? 71  ASP A C     1 
ATOM   572  O  O     . ASP A 1 81  ? 143.022 170.217 117.107 1.00 49.94  ? 71  ASP A O     1 
ATOM   573  C  CB    . ASP A 1 81  ? 141.948 170.499 114.374 1.00 48.71  ? 71  ASP A CB    1 
ATOM   574  C  CG    . ASP A 1 81  ? 140.460 170.561 114.619 1.00 55.90  ? 71  ASP A CG    1 
ATOM   575  O  OD1   . ASP A 1 81  ? 139.911 169.613 115.216 1.00 55.85  ? 71  ASP A OD1   1 
ATOM   576  O  OD2   . ASP A 1 81  ? 139.836 171.560 114.205 1.00 63.15  ? 71  ASP A OD2   1 
ATOM   577  N  N     . LYS A 1 82  ? 141.829 168.314 117.119 1.00 45.25  ? 72  LYS A N     1 
ATOM   578  C  CA    . LYS A 1 82  ? 141.766 168.276 118.567 1.00 38.40  ? 72  LYS A CA    1 
ATOM   579  C  C     . LYS A 1 82  ? 143.130 167.907 119.145 1.00 38.27  ? 72  LYS A C     1 
ATOM   580  O  O     . LYS A 1 82  ? 143.936 167.256 118.482 1.00 44.10  ? 72  LYS A O     1 
ATOM   581  C  CB    . LYS A 1 82  ? 140.715 167.275 119.028 1.00 41.76  ? 72  LYS A CB    1 
ATOM   582  C  CG    . LYS A 1 82  ? 139.291 167.760 118.836 1.00 47.37  ? 72  LYS A CG    1 
ATOM   583  C  CD    . LYS A 1 82  ? 138.309 166.892 119.591 1.00 51.02  ? 72  LYS A CD    1 
ATOM   584  C  CE    . LYS A 1 82  ? 136.890 167.143 119.131 1.00 49.69  ? 72  LYS A CE    1 
ATOM   585  N  NZ    . LYS A 1 82  ? 136.491 168.560 119.338 1.00 57.20  ? 72  LYS A NZ    1 
ATOM   586  N  N     . PRO A 1 83  ? 143.419 168.326 120.373 1.00 40.99  ? 73  PRO A N     1 
ATOM   587  C  CA    . PRO A 1 83  ? 144.720 168.013 120.975 1.00 40.17  ? 73  PRO A CA    1 
ATOM   588  C  C     . PRO A 1 83  ? 144.911 166.519 121.201 1.00 38.38  ? 73  PRO A C     1 
ATOM   589  O  O     . PRO A 1 83  ? 143.959 165.753 121.357 1.00 35.32  ? 73  PRO A O     1 
ATOM   590  C  CB    . PRO A 1 83  ? 144.685 168.773 122.304 1.00 39.00  ? 73  PRO A CB    1 
ATOM   591  C  CG    . PRO A 1 83  ? 143.699 169.854 122.091 1.00 42.36  ? 73  PRO A CG    1 
ATOM   592  C  CD    . PRO A 1 83  ? 142.657 169.284 121.189 1.00 42.88  ? 73  PRO A CD    1 
ATOM   593  N  N     . LEU A 1 84  ? 146.188 166.123 121.243 1.00 38.06  ? 74  LEU A N     1 
ATOM   594  C  CA    . LEU A 1 84  ? 146.561 164.713 121.323 1.00 36.86  ? 74  LEU A CA    1 
ATOM   595  C  C     . LEU A 1 84  ? 145.919 164.004 122.506 1.00 38.77  ? 74  LEU A C     1 
ATOM   596  O  O     . LEU A 1 84  ? 145.657 162.799 122.438 1.00 43.24  ? 74  LEU A O     1 
ATOM   597  C  CB    . LEU A 1 84  ? 148.087 164.582 121.403 1.00 33.80  ? 74  LEU A CB    1 
ATOM   598  C  CG    . LEU A 1 84  ? 148.676 163.249 121.876 1.00 33.86  ? 74  LEU A CG    1 
ATOM   599  C  CD1   . LEU A 1 84  ? 148.512 162.189 120.821 1.00 40.19  ? 74  LEU A CD1   1 
ATOM   600  C  CD2   . LEU A 1 84  ? 150.133 163.377 122.248 1.00 34.40  ? 74  LEU A CD2   1 
ATOM   601  N  N     . TYR A 1 85  ? 145.640 164.726 123.591 1.00 39.00  ? 75  TYR A N     1 
ATOM   602  C  CA    . TYR A 1 85  ? 145.130 164.066 124.785 1.00 36.92  ? 75  TYR A CA    1 
ATOM   603  C  C     . TYR A 1 85  ? 143.736 163.486 124.595 1.00 38.98  ? 75  TYR A C     1 
ATOM   604  O  O     . TYR A 1 85  ? 143.293 162.721 125.455 1.00 40.33  ? 75  TYR A O     1 
ATOM   605  C  CB    . TYR A 1 85  ? 145.148 165.029 125.980 1.00 41.59  ? 75  TYR A CB    1 
ATOM   606  C  CG    . TYR A 1 85  ? 144.011 166.028 126.042 1.00 42.89  ? 75  TYR A CG    1 
ATOM   607  C  CD1   . TYR A 1 85  ? 142.804 165.703 126.639 1.00 39.91  ? 75  TYR A CD1   1 
ATOM   608  C  CD2   . TYR A 1 85  ? 144.161 167.306 125.530 1.00 42.78  ? 75  TYR A CD2   1 
ATOM   609  C  CE1   . TYR A 1 85  ? 141.778 166.607 126.701 1.00 42.83  ? 75  TYR A CE1   1 
ATOM   610  C  CE2   . TYR A 1 85  ? 143.138 168.218 125.591 1.00 45.91  ? 75  TYR A CE2   1 
ATOM   611  C  CZ    . TYR A 1 85  ? 141.949 167.864 126.176 1.00 50.39  ? 75  TYR A CZ    1 
ATOM   612  O  OH    . TYR A 1 85  ? 140.924 168.774 126.236 1.00 61.08  ? 75  TYR A OH    1 
ATOM   613  N  N     . HIS A 1 86  ? 143.034 163.822 123.510 1.00 38.12  ? 76  HIS A N     1 
ATOM   614  C  CA    . HIS A 1 86  ? 141.752 163.174 123.250 1.00 34.98  ? 76  HIS A CA    1 
ATOM   615  C  C     . HIS A 1 86  ? 141.919 161.730 122.808 1.00 36.92  ? 76  HIS A C     1 
ATOM   616  O  O     . HIS A 1 86  ? 140.949 160.969 122.846 1.00 39.18  ? 76  HIS A O     1 
ATOM   617  C  CB    . HIS A 1 86  ? 140.953 163.937 122.198 1.00 41.77  ? 76  HIS A CB    1 
ATOM   618  C  CG    . HIS A 1 86  ? 140.430 165.254 122.673 1.00 45.30  ? 76  HIS A CG    1 
ATOM   619  N  ND1   . HIS A 1 86  ? 141.223 166.375 122.780 1.00 45.61  ? 76  HIS A ND1   1 
ATOM   620  C  CD2   . HIS A 1 86  ? 139.193 165.626 123.077 1.00 43.96  ? 76  HIS A CD2   1 
ATOM   621  C  CE1   . HIS A 1 86  ? 140.495 167.384 123.223 1.00 45.17  ? 76  HIS A CE1   1 
ATOM   622  N  NE2   . HIS A 1 86  ? 139.261 166.955 123.411 1.00 51.12  ? 76  HIS A NE2   1 
ATOM   623  N  N     . LEU A 1 87  ? 143.126 161.341 122.388 1.00 40.95  ? 77  LEU A N     1 
ATOM   624  C  CA    . LEU A 1 87  ? 143.401 159.935 122.116 1.00 38.84  ? 77  LEU A CA    1 
ATOM   625  C  C     . LEU A 1 87  ? 143.160 159.078 123.351 1.00 33.23  ? 77  LEU A C     1 
ATOM   626  O  O     . LEU A 1 87  ? 142.843 157.888 123.234 1.00 31.94  ? 77  LEU A O     1 
ATOM   627  C  CB    . LEU A 1 87  ? 144.842 159.768 121.636 1.00 30.87  ? 77  LEU A CB    1 
ATOM   628  C  CG    . LEU A 1 87  ? 145.187 160.060 120.172 1.00 37.91  ? 77  LEU A CG    1 
ATOM   629  C  CD1   . LEU A 1 87  ? 146.522 159.450 119.816 1.00 39.87  ? 77  LEU A CD1   1 
ATOM   630  C  CD2   . LEU A 1 87  ? 144.120 159.572 119.222 1.00 34.90  ? 77  LEU A CD2   1 
ATOM   631  N  N     . PHE A 1 88  ? 143.294 159.664 124.536 1.00 26.59  ? 78  PHE A N     1 
ATOM   632  C  CA    . PHE A 1 88  ? 143.193 158.938 125.788 1.00 26.01  ? 78  PHE A CA    1 
ATOM   633  C  C     . PHE A 1 88  ? 141.809 159.005 126.415 1.00 38.29  ? 78  PHE A C     1 
ATOM   634  O  O     . PHE A 1 88  ? 141.620 158.460 127.506 1.00 42.42  ? 78  PHE A O     1 
ATOM   635  C  CB    . PHE A 1 88  ? 144.233 159.465 126.776 1.00 24.94  ? 78  PHE A CB    1 
ATOM   636  C  CG    . PHE A 1 88  ? 145.647 159.387 126.273 1.00 26.69  ? 78  PHE A CG    1 
ATOM   637  C  CD1   . PHE A 1 88  ? 146.193 158.180 125.883 1.00 26.89  ? 78  PHE A CD1   1 
ATOM   638  C  CD2   . PHE A 1 88  ? 146.433 160.519 126.203 1.00 30.54  ? 78  PHE A CD2   1 
ATOM   639  C  CE1   . PHE A 1 88  ? 147.486 158.106 125.426 1.00 18.71  ? 78  PHE A CE1   1 
ATOM   640  C  CE2   . PHE A 1 88  ? 147.729 160.449 125.747 1.00 26.88  ? 78  PHE A CE2   1 
ATOM   641  C  CZ    . PHE A 1 88  ? 148.254 159.241 125.356 1.00 21.80  ? 78  PHE A CZ    1 
ATOM   642  N  N     . THR A 1 89  ? 140.839 159.644 125.765 1.00 34.87  ? 79  THR A N     1 
ATOM   643  C  CA    . THR A 1 89  ? 139.497 159.736 126.321 1.00 30.85  ? 79  THR A CA    1 
ATOM   644  C  C     . THR A 1 89  ? 138.632 158.577 125.836 1.00 34.68  ? 79  THR A C     1 
ATOM   645  O  O     . THR A 1 89  ? 138.976 157.858 124.902 1.00 45.38  ? 79  THR A O     1 
ATOM   646  C  CB    . THR A 1 89  ? 138.854 161.070 125.959 1.00 31.91  ? 79  THR A CB    1 
ATOM   647  O  OG1   . THR A 1 89  ? 138.520 161.081 124.568 1.00 40.23  ? 79  THR A OG1   1 
ATOM   648  C  CG2   . THR A 1 89  ? 139.811 162.206 126.251 1.00 35.19  ? 79  THR A CG2   1 
ATOM   649  N  N     . LYS A 1 90  ? 137.486 158.400 126.485 1.00 35.19  ? 80  LYS A N     1 
ATOM   650  C  CA    . LYS A 1 90  ? 136.661 157.227 126.228 1.00 36.45  ? 80  LYS A CA    1 
ATOM   651  C  C     . LYS A 1 90  ? 135.794 157.351 124.980 1.00 42.63  ? 80  LYS A C     1 
ATOM   652  O  O     . LYS A 1 90  ? 135.167 156.361 124.586 1.00 43.61  ? 80  LYS A O     1 
ATOM   653  C  CB    . LYS A 1 90  ? 135.776 156.930 127.440 1.00 36.00  ? 80  LYS A CB    1 
ATOM   654  C  CG    . LYS A 1 90  ? 135.567 155.450 127.688 1.00 33.26  ? 80  LYS A CG    1 
ATOM   655  C  CD    . LYS A 1 90  ? 135.125 155.196 129.111 1.00 42.21  ? 80  LYS A CD    1 
ATOM   656  C  CE    . LYS A 1 90  ? 135.026 153.711 129.406 1.00 39.05  ? 80  LYS A CE    1 
ATOM   657  N  NZ    . LYS A 1 90  ? 135.090 153.443 130.865 1.00 31.77  ? 80  LYS A NZ    1 
ATOM   658  N  N     . LYS A 1 91  ? 135.744 158.517 124.344 1.00 39.26  ? 81  LYS A N     1 
ATOM   659  C  CA    . LYS A 1 91  ? 134.978 158.676 123.117 1.00 39.17  ? 81  LYS A CA    1 
ATOM   660  C  C     . LYS A 1 91  ? 135.790 158.392 121.864 1.00 42.49  ? 81  LYS A C     1 
ATOM   661  O  O     . LYS A 1 91  ? 135.283 158.594 120.758 1.00 41.42  ? 81  LYS A O     1 
ATOM   662  C  CB    . LYS A 1 91  ? 134.399 160.086 123.019 1.00 44.10  ? 81  LYS A CB    1 
ATOM   663  C  CG    . LYS A 1 91  ? 133.611 160.538 124.219 1.00 52.89  ? 81  LYS A CG    1 
ATOM   664  C  CD    . LYS A 1 91  ? 133.007 161.900 123.952 1.00 67.51  ? 81  LYS A CD    1 
ATOM   665  C  CE    . LYS A 1 91  ? 132.246 161.900 122.639 1.00 73.22  ? 81  LYS A CE    1 
ATOM   666  N  NZ    . LYS A 1 91  ? 131.492 163.163 122.423 1.00 81.68  ? 81  LYS A NZ    1 
ATOM   667  N  N     . TYR A 1 92  ? 137.031 157.944 121.995 1.00 42.96  ? 82  TYR A N     1 
ATOM   668  C  CA    . TYR A 1 92  ? 137.854 157.622 120.843 1.00 44.44  ? 82  TYR A CA    1 
ATOM   669  C  C     . TYR A 1 92  ? 138.219 156.146 120.909 1.00 44.99  ? 82  TYR A C     1 
ATOM   670  O  O     . TYR A 1 92  ? 138.581 155.643 121.976 1.00 42.87  ? 82  TYR A O     1 
ATOM   671  C  CB    . TYR A 1 92  ? 139.118 158.481 120.805 1.00 39.82  ? 82  TYR A CB    1 
ATOM   672  C  CG    . TYR A 1 92  ? 139.921 158.285 119.547 1.00 43.97  ? 82  TYR A CG    1 
ATOM   673  C  CD1   . TYR A 1 92  ? 139.521 158.869 118.361 1.00 46.29  ? 82  TYR A CD1   1 
ATOM   674  C  CD2   . TYR A 1 92  ? 141.039 157.486 119.527 1.00 42.55  ? 82  TYR A CD2   1 
ATOM   675  C  CE1   . TYR A 1 92  ? 140.233 158.695 117.200 1.00 47.36  ? 82  TYR A CE1   1 
ATOM   676  C  CE2   . TYR A 1 92  ? 141.752 157.299 118.366 1.00 47.19  ? 82  TYR A CE2   1 
ATOM   677  C  CZ    . TYR A 1 92  ? 141.350 157.909 117.208 1.00 49.26  ? 82  TYR A CZ    1 
ATOM   678  O  OH    . TYR A 1 92  ? 142.068 157.725 116.052 1.00 55.02  ? 82  TYR A OH    1 
ATOM   679  N  N     . HIS A 1 93  ? 138.117 155.461 119.771 1.00 46.59  ? 83  HIS A N     1 
ATOM   680  C  CA    . HIS A 1 93  ? 138.369 154.027 119.711 1.00 40.43  ? 83  HIS A CA    1 
ATOM   681  C  C     . HIS A 1 93  ? 139.751 153.702 120.256 1.00 35.58  ? 83  HIS A C     1 
ATOM   682  O  O     . HIS A 1 93  ? 140.736 154.362 119.916 1.00 36.12  ? 83  HIS A O     1 
ATOM   683  C  CB    . HIS A 1 93  ? 138.240 153.542 118.267 1.00 43.28  ? 83  HIS A CB    1 
ATOM   684  C  CG    . HIS A 1 93  ? 137.922 152.086 118.141 1.00 49.97  ? 83  HIS A CG    1 
ATOM   685  N  ND1   . HIS A 1 93  ? 138.888 151.130 117.916 1.00 46.19  ? 83  HIS A ND1   1 
ATOM   686  C  CD2   . HIS A 1 93  ? 136.745 151.422 118.210 1.00 51.98  ? 83  HIS A CD2   1 
ATOM   687  C  CE1   . HIS A 1 93  ? 138.320 149.940 117.855 1.00 43.53  ? 83  HIS A CE1   1 
ATOM   688  N  NE2   . HIS A 1 93  ? 137.020 150.089 118.029 1.00 49.79  ? 83  HIS A NE2   1 
ATOM   689  N  N     . THR A 1 94  ? 139.815 152.672 121.106 1.00 35.17  ? 84  THR A N     1 
ATOM   690  C  CA    . THR A 1 94  ? 141.049 152.361 121.823 1.00 37.86  ? 84  THR A CA    1 
ATOM   691  C  C     . THR A 1 94  ? 142.166 151.953 120.870 1.00 32.09  ? 84  THR A C     1 
ATOM   692  O  O     . THR A 1 94  ? 143.276 152.496 120.924 1.00 25.37  ? 84  THR A O     1 
ATOM   693  C  CB    . THR A 1 94  ? 140.799 151.246 122.837 1.00 38.04  ? 84  THR A CB    1 
ATOM   694  O  OG1   . THR A 1 94  ? 140.329 150.081 122.151 1.00 39.45  ? 84  THR A OG1   1 
ATOM   695  C  CG2   . THR A 1 94  ? 139.768 151.670 123.861 1.00 33.92  ? 84  THR A CG2   1 
ATOM   696  N  N     . ASN A 1 95  ? 141.888 150.982 119.998 1.00 32.08  ? 85  ASN A N     1 
ATOM   697  C  CA    . ASN A 1 95  ? 142.931 150.424 119.146 1.00 25.69  ? 85  ASN A CA    1 
ATOM   698  C  C     . ASN A 1 95  ? 143.434 151.445 118.141 1.00 29.26  ? 85  ASN A C     1 
ATOM   699  O  O     . ASN A 1 95  ? 144.628 151.476 117.835 1.00 31.30  ? 85  ASN A O     1 
ATOM   700  C  CB    . ASN A 1 95  ? 142.418 149.173 118.440 1.00 21.40  ? 85  ASN A CB    1 
ATOM   701  C  CG    . ASN A 1 95  ? 142.280 147.994 119.376 1.00 19.60  ? 85  ASN A CG    1 
ATOM   702  O  OD1   . ASN A 1 95  ? 143.009 147.879 120.354 1.00 16.58  ? 85  ASN A OD1   1 
ATOM   703  N  ND2   . ASN A 1 95  ? 141.345 147.110 119.078 1.00 22.79  ? 85  ASN A ND2   1 
ATOM   704  N  N     . ASN A 1 96  ? 142.546 152.285 117.610 1.00 33.41  ? 86  ASN A N     1 
ATOM   705  C  CA    . ASN A 1 96  ? 142.997 153.340 116.707 1.00 33.70  ? 86  ASN A CA    1 
ATOM   706  C  C     . ASN A 1 96  ? 143.944 154.300 117.411 1.00 33.98  ? 86  ASN A C     1 
ATOM   707  O  O     . ASN A 1 96  ? 144.972 154.686 116.848 1.00 39.78  ? 86  ASN A O     1 
ATOM   708  C  CB    . ASN A 1 96  ? 141.800 154.087 116.123 1.00 42.39  ? 86  ASN A CB    1 
ATOM   709  C  CG    . ASN A 1 96  ? 140.940 153.204 115.241 1.00 48.82  ? 86  ASN A CG    1 
ATOM   710  O  OD1   . ASN A 1 96  ? 139.788 152.921 115.555 1.00 53.54  ? 86  ASN A OD1   1 
ATOM   711  N  ND2   . ASN A 1 96  ? 141.501 152.764 114.129 1.00 49.09  ? 86  ASN A ND2   1 
ATOM   712  N  N     . ALA A 1 97  ? 143.624 154.688 118.646 1.00 31.91  ? 87  ALA A N     1 
ATOM   713  C  CA    . ALA A 1 97  ? 144.513 155.561 119.406 1.00 30.90  ? 87  ALA A CA    1 
ATOM   714  C  C     . ALA A 1 97  ? 145.859 154.897 119.646 1.00 34.71  ? 87  ALA A C     1 
ATOM   715  O  O     . ALA A 1 97  ? 146.914 155.505 119.423 1.00 37.03  ? 87  ALA A O     1 
ATOM   716  C  CB    . ALA A 1 97  ? 143.863 155.941 120.734 1.00 28.17  ? 87  ALA A CB    1 
ATOM   717  N  N     . ASP A 1 98  ? 145.838 153.641 120.104 1.00 34.81  ? 88  ASP A N     1 
ATOM   718  C  CA    . ASP A 1 98  ? 147.077 152.912 120.348 1.00 28.36  ? 88  ASP A CA    1 
ATOM   719  C  C     . ASP A 1 98  ? 147.926 152.858 119.094 1.00 29.28  ? 88  ASP A C     1 
ATOM   720  O  O     . ASP A 1 98  ? 149.115 153.187 119.121 1.00 32.30  ? 88  ASP A O     1 
ATOM   721  C  CB    . ASP A 1 98  ? 146.782 151.490 120.823 1.00 30.35  ? 88  ASP A CB    1 
ATOM   722  C  CG    . ASP A 1 98  ? 146.080 151.447 122.151 1.00 37.36  ? 88  ASP A CG    1 
ATOM   723  O  OD1   . ASP A 1 98  ? 145.885 152.517 122.758 1.00 38.32  ? 88  ASP A OD1   1 
ATOM   724  O  OD2   . ASP A 1 98  ? 145.732 150.333 122.592 1.00 35.63  ? 88  ASP A OD2   1 
ATOM   725  N  N     . ASN A 1 99  ? 147.326 152.445 117.979 1.00 25.39  ? 89  ASN A N     1 
ATOM   726  C  CA    . ASN A 1 99  ? 148.088 152.251 116.756 1.00 24.24  ? 89  ASN A CA    1 
ATOM   727  C  C     . ASN A 1 99  ? 148.612 153.570 116.214 1.00 28.00  ? 89  ASN A C     1 
ATOM   728  O  O     . ASN A 1 99  ? 149.776 153.659 115.818 1.00 33.01  ? 89  ASN A O     1 
ATOM   729  C  CB    . ASN A 1 99  ? 147.226 151.538 115.722 1.00 23.87  ? 89  ASN A CB    1 
ATOM   730  C  CG    . ASN A 1 99  ? 146.889 150.124 116.125 1.00 20.48  ? 89  ASN A CG    1 
ATOM   731  O  OD1   . ASN A 1 99  ? 147.316 149.643 117.171 1.00 14.79  ? 89  ASN A OD1   1 
ATOM   732  N  ND2   . ASN A 1 99  ? 146.110 149.450 115.298 1.00 24.94  ? 89  ASN A ND2   1 
ATOM   733  N  N     . LEU A 1 100 ? 147.779 154.612 116.200 1.00 27.73  ? 90  LEU A N     1 
ATOM   734  C  CA    . LEU A 1 100 ? 148.227 155.908 115.707 1.00 30.81  ? 90  LEU A CA    1 
ATOM   735  C  C     . LEU A 1 100 ? 149.393 156.435 116.534 1.00 32.78  ? 90  LEU A C     1 
ATOM   736  O  O     . LEU A 1 100 ? 150.444 156.802 115.987 1.00 37.82  ? 90  LEU A O     1 
ATOM   737  C  CB    . LEU A 1 100 ? 147.059 156.894 115.715 1.00 32.73  ? 90  LEU A CB    1 
ATOM   738  C  CG    . LEU A 1 100 ? 147.318 158.317 115.217 1.00 32.33  ? 90  LEU A CG    1 
ATOM   739  C  CD1   . LEU A 1 100 ? 148.201 158.328 113.982 1.00 36.61  ? 90  LEU A CD1   1 
ATOM   740  C  CD2   . LEU A 1 100 ? 146.006 159.000 114.926 1.00 34.42  ? 90  LEU A CD2   1 
ATOM   741  N  N     . LEU A 1 101 ? 149.239 156.455 117.860 1.00 28.52  ? 91  LEU A N     1 
ATOM   742  C  CA    . LEU A 1 101 ? 150.310 156.957 118.709 1.00 24.74  ? 91  LEU A CA    1 
ATOM   743  C  C     . LEU A 1 101 ? 151.573 156.116 118.561 1.00 30.77  ? 91  LEU A C     1 
ATOM   744  O  O     . LEU A 1 101 ? 152.678 156.659 118.422 1.00 33.18  ? 91  LEU A O     1 
ATOM   745  C  CB    . LEU A 1 101 ? 149.842 156.987 120.161 1.00 26.26  ? 91  LEU A CB    1 
ATOM   746  C  CG    . LEU A 1 101 ? 150.699 157.760 121.156 1.00 30.73  ? 91  LEU A CG    1 
ATOM   747  C  CD1   . LEU A 1 101 ? 151.039 159.119 120.599 1.00 34.39  ? 91  LEU A CD1   1 
ATOM   748  C  CD2   . LEU A 1 101 ? 149.953 157.896 122.458 1.00 23.77  ? 91  LEU A CD2   1 
ATOM   749  N  N     . TYR A 1 102 ? 151.429 154.787 118.563 1.00 33.21  ? 92  TYR A N     1 
ATOM   750  C  CA    . TYR A 1 102 ? 152.595 153.916 118.507 1.00 29.26  ? 92  TYR A CA    1 
ATOM   751  C  C     . TYR A 1 102 ? 153.343 154.077 117.197 1.00 27.83  ? 92  TYR A C     1 
ATOM   752  O  O     . TYR A 1 102 ? 154.572 154.132 117.183 1.00 30.48  ? 92  TYR A O     1 
ATOM   753  C  CB    . TYR A 1 102 ? 152.200 152.450 118.691 1.00 27.13  ? 92  TYR A CB    1 
ATOM   754  C  CG    . TYR A 1 102 ? 153.365 151.552 118.362 1.00 27.98  ? 92  TYR A CG    1 
ATOM   755  C  CD1   . TYR A 1 102 ? 154.503 151.555 119.159 1.00 27.62  ? 92  TYR A CD1   1 
ATOM   756  C  CD2   . TYR A 1 102 ? 153.363 150.760 117.226 1.00 24.17  ? 92  TYR A CD2   1 
ATOM   757  C  CE1   . TYR A 1 102 ? 155.588 150.774 118.855 1.00 24.79  ? 92  TYR A CE1   1 
ATOM   758  C  CE2   . TYR A 1 102 ? 154.448 149.972 116.914 1.00 28.02  ? 92  TYR A CE2   1 
ATOM   759  C  CZ    . TYR A 1 102 ? 155.559 149.985 117.733 1.00 28.48  ? 92  TYR A CZ    1 
ATOM   760  O  OH    . TYR A 1 102 ? 156.647 149.205 117.437 1.00 36.31  ? 92  TYR A OH    1 
ATOM   761  N  N     . TYR A 1 103 ? 152.623 154.113 116.078 1.00 27.31  ? 93  TYR A N     1 
ATOM   762  C  CA    . TYR A 1 103 ? 153.309 154.174 114.799 1.00 25.33  ? 93  TYR A CA    1 
ATOM   763  C  C     . TYR A 1 103 ? 153.886 155.553 114.552 1.00 33.54  ? 93  TYR A C     1 
ATOM   764  O  O     . TYR A 1 103 ? 154.920 155.675 113.885 1.00 41.23  ? 93  TYR A O     1 
ATOM   765  C  CB    . TYR A 1 103 ? 152.368 153.741 113.679 1.00 28.01  ? 93  TYR A CB    1 
ATOM   766  C  CG    . TYR A 1 103 ? 152.115 152.255 113.716 1.00 28.50  ? 93  TYR A CG    1 
ATOM   767  C  CD1   . TYR A 1 103 ? 153.171 151.362 113.747 1.00 28.55  ? 93  TYR A CD1   1 
ATOM   768  C  CD2   . TYR A 1 103 ? 150.831 151.747 113.755 1.00 25.06  ? 93  TYR A CD2   1 
ATOM   769  C  CE1   . TYR A 1 103 ? 152.955 150.013 113.796 1.00 26.89  ? 93  TYR A CE1   1 
ATOM   770  C  CE2   . TYR A 1 103 ? 150.607 150.396 113.809 1.00 23.17  ? 93  TYR A CE2   1 
ATOM   771  C  CZ    . TYR A 1 103 ? 151.674 149.535 113.829 1.00 26.10  ? 93  TYR A CZ    1 
ATOM   772  O  OH    . TYR A 1 103 ? 151.463 148.182 113.885 1.00 27.76  ? 93  TYR A OH    1 
ATOM   773  N  N     . TYR A 1 104 ? 153.276 156.599 115.114 1.00 34.95  ? 94  TYR A N     1 
ATOM   774  C  CA    . TYR A 1 104 ? 153.945 157.894 115.109 1.00 37.89  ? 94  TYR A CA    1 
ATOM   775  C  C     . TYR A 1 104 ? 155.268 157.820 115.863 1.00 44.83  ? 94  TYR A C     1 
ATOM   776  O  O     . TYR A 1 104 ? 156.310 158.257 115.360 1.00 43.89  ? 94  TYR A O     1 
ATOM   777  C  CB    . TYR A 1 104 ? 153.038 158.961 115.713 1.00 28.92  ? 94  TYR A CB    1 
ATOM   778  C  CG    . TYR A 1 104 ? 153.617 160.347 115.617 1.00 35.11  ? 94  TYR A CG    1 
ATOM   779  C  CD1   . TYR A 1 104 ? 153.449 161.110 114.475 1.00 43.16  ? 94  TYR A CD1   1 
ATOM   780  C  CD2   . TYR A 1 104 ? 154.346 160.889 116.662 1.00 40.56  ? 94  TYR A CD2   1 
ATOM   781  C  CE1   . TYR A 1 104 ? 153.982 162.376 114.379 1.00 43.45  ? 94  TYR A CE1   1 
ATOM   782  C  CE2   . TYR A 1 104 ? 154.884 162.150 116.575 1.00 43.78  ? 94  TYR A CE2   1 
ATOM   783  C  CZ    . TYR A 1 104 ? 154.698 162.889 115.432 1.00 44.43  ? 94  TYR A CZ    1 
ATOM   784  O  OH    . TYR A 1 104 ? 155.232 164.151 115.339 1.00 50.68  ? 94  TYR A OH    1 
ATOM   785  N  N     . ILE A 1 105 ? 155.248 157.245 117.069 1.00 42.60  ? 95  ILE A N     1 
ATOM   786  C  CA    . ILE A 1 105 ? 156.453 157.193 117.893 1.00 40.24  ? 95  ILE A CA    1 
ATOM   787  C  C     . ILE A 1 105 ? 157.521 156.319 117.245 1.00 45.24  ? 95  ILE A C     1 
ATOM   788  O  O     . ILE A 1 105 ? 158.714 156.642 117.278 1.00 49.69  ? 95  ILE A O     1 
ATOM   789  C  CB    . ILE A 1 105 ? 156.094 156.712 119.310 1.00 40.79  ? 95  ILE A CB    1 
ATOM   790  C  CG1   . ILE A 1 105 ? 155.271 157.781 120.026 1.00 40.02  ? 95  ILE A CG1   1 
ATOM   791  C  CG2   . ILE A 1 105 ? 157.336 156.364 120.102 1.00 44.22  ? 95  ILE A CG2   1 
ATOM   792  C  CD1   . ILE A 1 105 ? 155.133 157.552 121.505 1.00 41.43  ? 95  ILE A CD1   1 
ATOM   793  N  N     . LYS A 1 106 ? 157.110 155.204 116.646 1.00 45.99  ? 96  LYS A N     1 
ATOM   794  C  CA    . LYS A 1 106 ? 158.050 154.293 116.005 1.00 41.57  ? 96  LYS A CA    1 
ATOM   795  C  C     . LYS A 1 106 ? 158.665 154.911 114.759 1.00 46.12  ? 96  LYS A C     1 
ATOM   796  O  O     . LYS A 1 106 ? 159.871 154.779 114.529 1.00 53.43  ? 96  LYS A O     1 
ATOM   797  C  CB    . LYS A 1 106 ? 157.344 152.982 115.666 1.00 33.50  ? 96  LYS A CB    1 
ATOM   798  C  CG    . LYS A 1 106 ? 158.182 151.998 114.887 1.00 35.83  ? 96  LYS A CG    1 
ATOM   799  C  CD    . LYS A 1 106 ? 157.385 150.748 114.575 1.00 33.29  ? 96  LYS A CD    1 
ATOM   800  C  CE    . LYS A 1 106 ? 158.229 149.717 113.858 1.00 32.54  ? 96  LYS A CE    1 
ATOM   801  N  NZ    . LYS A 1 106 ? 157.523 148.415 113.754 1.00 36.73  ? 96  LYS A NZ    1 
ATOM   802  N  N     . GLU A 1 107 ? 157.858 155.592 113.941 1.00 44.27  ? 97  GLU A N     1 
ATOM   803  C  CA    . GLU A 1 107 ? 158.394 156.200 112.730 1.00 50.33  ? 97  GLU A CA    1 
ATOM   804  C  C     . GLU A 1 107 ? 159.369 157.331 113.022 1.00 51.79  ? 97  GLU A C     1 
ATOM   805  O  O     . GLU A 1 107 ? 160.175 157.674 112.153 1.00 51.62  ? 97  GLU A O     1 
ATOM   806  C  CB    . GLU A 1 107 ? 157.259 156.717 111.848 1.00 56.49  ? 97  GLU A CB    1 
ATOM   807  C  CG    . GLU A 1 107 ? 156.464 155.620 111.173 1.00 55.73  ? 97  GLU A CG    1 
ATOM   808  C  CD    . GLU A 1 107 ? 157.349 154.616 110.467 1.00 63.61  ? 97  GLU A CD    1 
ATOM   809  O  OE1   . GLU A 1 107 ? 158.254 155.041 109.717 1.00 61.46  ? 97  GLU A OE1   1 
ATOM   810  O  OE2   . GLU A 1 107 ? 157.145 153.401 110.671 1.00 67.12  ? 97  GLU A OE2   1 
ATOM   811  N  N     . LYS A 1 108 ? 159.320 157.912 114.219 1.00 53.54  ? 98  LYS A N     1 
ATOM   812  C  CA    . LYS A 1 108 ? 160.180 159.028 114.574 1.00 54.87  ? 98  LYS A CA    1 
ATOM   813  C  C     . LYS A 1 108 ? 161.159 158.718 115.699 1.00 53.83  ? 98  LYS A C     1 
ATOM   814  O  O     . LYS A 1 108 ? 161.924 159.608 116.086 1.00 59.49  ? 98  LYS A O     1 
ATOM   815  C  CB    . LYS A 1 108 ? 159.332 160.247 114.960 1.00 54.56  ? 98  LYS A CB    1 
ATOM   816  C  CG    . LYS A 1 108 ? 158.570 160.856 113.799 1.00 54.98  ? 98  LYS A CG    1 
ATOM   817  C  CD    . LYS A 1 108 ? 158.181 162.289 114.095 1.00 58.68  ? 98  LYS A CD    1 
ATOM   818  C  CE    . LYS A 1 108 ? 157.817 163.031 112.826 1.00 58.75  ? 98  LYS A CE    1 
ATOM   819  N  NZ    . LYS A 1 108 ? 157.662 164.489 113.070 1.00 51.85  ? 98  LYS A NZ    1 
ATOM   820  N  N     . ASN A 1 109 ? 161.159 157.496 116.232 1.00 50.09  ? 99  ASN A N     1 
ATOM   821  C  CA    . ASN A 1 109 ? 162.117 157.075 117.256 1.00 50.23  ? 99  ASN A CA    1 
ATOM   822  C  C     . ASN A 1 109 ? 162.115 158.037 118.443 1.00 51.03  ? 99  ASN A C     1 
ATOM   823  O  O     . ASN A 1 109 ? 163.152 158.546 118.872 1.00 46.46  ? 99  ASN A O     1 
ATOM   824  C  CB    . ASN A 1 109 ? 163.521 156.938 116.662 1.00 50.94  ? 99  ASN A CB    1 
ATOM   825  C  CG    . ASN A 1 109 ? 164.479 156.209 117.584 1.00 53.91  ? 99  ASN A CG    1 
ATOM   826  O  OD1   . ASN A 1 109 ? 164.119 155.824 118.693 1.00 53.21  ? 99  ASN A OD1   1 
ATOM   827  N  ND2   . ASN A 1 109 ? 165.710 156.020 117.128 1.00 52.39  ? 99  ASN A ND2   1 
ATOM   828  N  N     . LEU A 1 110 ? 160.920 158.294 118.972 1.00 49.92  ? 100 LEU A N     1 
ATOM   829  C  CA    . LEU A 1 110 ? 160.783 159.286 120.031 1.00 48.33  ? 100 LEU A CA    1 
ATOM   830  C  C     . LEU A 1 110 ? 161.231 158.750 121.386 1.00 52.21  ? 100 LEU A C     1 
ATOM   831  O  O     . LEU A 1 110 ? 161.839 159.486 122.172 1.00 50.14  ? 100 LEU A O     1 
ATOM   832  C  CB    . LEU A 1 110 ? 159.343 159.781 120.083 1.00 43.89  ? 100 LEU A CB    1 
ATOM   833  C  CG    . LEU A 1 110 ? 158.924 160.357 118.732 1.00 47.42  ? 100 LEU A CG    1 
ATOM   834  C  CD1   . LEU A 1 110 ? 157.432 160.522 118.648 1.00 49.38  ? 100 LEU A CD1   1 
ATOM   835  C  CD2   . LEU A 1 110 ? 159.628 161.677 118.475 1.00 53.08  ? 100 LEU A CD2   1 
ATOM   836  N  N     . ASP A 1 111 ? 160.949 157.481 121.682 1.00 53.82  ? 101 ASP A N     1 
ATOM   837  C  CA    . ASP A 1 111 ? 161.331 156.925 122.974 1.00 50.37  ? 101 ASP A CA    1 
ATOM   838  C  C     . ASP A 1 111 ? 162.738 156.335 122.981 1.00 55.49  ? 101 ASP A C     1 
ATOM   839  O  O     . ASP A 1 111 ? 163.187 155.861 124.029 1.00 56.54  ? 101 ASP A O     1 
ATOM   840  C  CB    . ASP A 1 111 ? 160.318 155.868 123.418 1.00 42.87  ? 101 ASP A CB    1 
ATOM   841  C  CG    . ASP A 1 111 ? 160.202 154.726 122.443 1.00 45.79  ? 101 ASP A CG    1 
ATOM   842  O  OD1   . ASP A 1 111 ? 160.679 154.866 121.298 1.00 49.24  ? 101 ASP A OD1   1 
ATOM   843  O  OD2   . ASP A 1 111 ? 159.645 153.679 122.830 1.00 44.60  ? 101 ASP A OD2   1 
ATOM   844  N  N     . GLY A 1 112 ? 163.435 156.347 121.848 1.00 52.63  ? 102 GLY A N     1 
ATOM   845  C  CA    . GLY A 1 112 ? 164.828 155.951 121.807 1.00 52.45  ? 102 GLY A CA    1 
ATOM   846  C  C     . GLY A 1 112 ? 165.104 154.465 121.831 1.00 57.06  ? 102 GLY A C     1 
ATOM   847  O  O     . GLY A 1 112 ? 166.229 154.070 122.159 1.00 59.97  ? 102 GLY A O     1 
ATOM   848  N  N     . TYR A 1 113 ? 164.126 153.627 121.486 1.00 54.58  ? 103 TYR A N     1 
ATOM   849  C  CA    . TYR A 1 113 ? 164.283 152.176 121.537 1.00 49.90  ? 103 TYR A CA    1 
ATOM   850  C  C     . TYR A 1 113 ? 165.433 151.689 120.664 1.00 52.90  ? 103 TYR A C     1 
ATOM   851  O  O     . TYR A 1 113 ? 165.347 151.721 119.434 1.00 51.62  ? 103 TYR A O     1 
ATOM   852  C  CB    . TYR A 1 113 ? 162.981 151.505 121.103 1.00 44.74  ? 103 TYR A CB    1 
ATOM   853  C  CG    . TYR A 1 113 ? 162.883 150.020 121.369 1.00 41.41  ? 103 TYR A CG    1 
ATOM   854  C  CD1   . TYR A 1 113 ? 162.713 149.531 122.655 1.00 37.33  ? 103 TYR A CD1   1 
ATOM   855  C  CD2   . TYR A 1 113 ? 162.920 149.109 120.327 1.00 41.01  ? 103 TYR A CD2   1 
ATOM   856  C  CE1   . TYR A 1 113 ? 162.603 148.177 122.893 1.00 32.57  ? 103 TYR A CE1   1 
ATOM   857  C  CE2   . TYR A 1 113 ? 162.812 147.756 120.558 1.00 40.06  ? 103 TYR A CE2   1 
ATOM   858  C  CZ    . TYR A 1 113 ? 162.654 147.296 121.842 1.00 39.02  ? 103 TYR A CZ    1 
ATOM   859  O  OH    . TYR A 1 113 ? 162.546 145.948 122.069 1.00 39.69  ? 103 TYR A OH    1 
ATOM   860  N  N     . LYS A 1 114 ? 166.507 151.222 121.296 1.00 54.96  ? 104 LYS A N     1 
ATOM   861  C  CA    . LYS A 1 114 ? 167.644 150.636 120.601 1.00 54.33  ? 104 LYS A CA    1 
ATOM   862  C  C     . LYS A 1 114 ? 167.652 149.117 120.680 1.00 53.41  ? 104 LYS A C     1 
ATOM   863  O  O     . LYS A 1 114 ? 168.664 148.495 120.344 1.00 59.14  ? 104 LYS A O     1 
ATOM   864  C  CB    . LYS A 1 114 ? 168.954 151.184 121.167 1.00 53.71  ? 104 LYS A CB    1 
ATOM   865  C  CG    . LYS A 1 114 ? 169.160 152.672 120.957 1.00 57.88  ? 104 LYS A CG    1 
ATOM   866  C  CD    . LYS A 1 114 ? 170.564 153.086 121.371 1.00 65.80  ? 104 LYS A CD    1 
ATOM   867  C  CE    . LYS A 1 114 ? 170.772 154.582 121.221 1.00 60.28  ? 104 LYS A CE    1 
ATOM   868  N  NZ    . LYS A 1 114 ? 172.195 154.968 121.427 1.00 56.57  ? 104 LYS A NZ    1 
ATOM   869  N  N     . GLY A 1 115 ? 166.556 148.512 121.111 1.00 46.76  ? 105 GLY A N     1 
ATOM   870  C  CA    . GLY A 1 115 ? 166.484 147.087 121.347 1.00 36.38  ? 105 GLY A CA    1 
ATOM   871  C  C     . GLY A 1 115 ? 166.518 146.779 122.833 1.00 41.82  ? 105 GLY A C     1 
ATOM   872  O  O     . GLY A 1 115 ? 166.507 147.668 123.687 1.00 45.29  ? 105 GLY A O     1 
ATOM   873  N  N     . ASN A 1 116 ? 166.559 145.485 123.133 1.00 43.93  ? 106 ASN A N     1 
ATOM   874  C  CA    . ASN A 1 116 ? 166.607 144.999 124.502 1.00 43.61  ? 106 ASN A CA    1 
ATOM   875  C  C     . ASN A 1 116 ? 167.665 143.910 124.637 1.00 48.16  ? 106 ASN A C     1 
ATOM   876  O  O     . ASN A 1 116 ? 168.113 143.325 123.649 1.00 50.57  ? 106 ASN A O     1 
ATOM   877  C  CB    . ASN A 1 116 ? 165.229 144.505 124.962 1.00 32.57  ? 106 ASN A CB    1 
ATOM   878  C  CG    . ASN A 1 116 ? 164.707 143.372 124.121 1.00 36.64  ? 106 ASN A CG    1 
ATOM   879  O  OD1   . ASN A 1 116 ? 165.396 142.869 123.247 1.00 45.41  ? 106 ASN A OD1   1 
ATOM   880  N  ND2   . ASN A 1 116 ? 163.479 142.965 124.378 1.00 38.22  ? 106 ASN A ND2   1 
ATOM   881  N  N     . THR A 1 117 ? 168.071 143.657 125.883 1.00 47.83  ? 107 THR A N     1 
ATOM   882  C  CA    . THR A 1 117 ? 169.216 142.786 126.140 1.00 45.58  ? 107 THR A CA    1 
ATOM   883  C  C     . THR A 1 117 ? 168.943 141.349 125.713 1.00 43.78  ? 107 THR A C     1 
ATOM   884  O  O     . THR A 1 117 ? 169.782 140.712 125.066 1.00 54.00  ? 107 THR A O     1 
ATOM   885  C  CB    . THR A 1 117 ? 169.592 142.838 127.620 1.00 53.95  ? 107 THR A CB    1 
ATOM   886  O  OG1   . THR A 1 117 ? 170.185 144.109 127.920 1.00 62.82  ? 107 THR A OG1   1 
ATOM   887  C  CG2   . THR A 1 117 ? 170.577 141.739 127.954 1.00 51.69  ? 107 THR A CG2   1 
ATOM   888  N  N     . LEU A 1 118 ? 167.777 140.820 126.058 1.00 43.63  ? 108 LEU A N     1 
ATOM   889  C  CA    . LEU A 1 118 ? 167.483 139.425 125.763 1.00 40.32  ? 108 LEU A CA    1 
ATOM   890  C  C     . LEU A 1 118 ? 166.992 139.207 124.341 1.00 44.98  ? 108 LEU A C     1 
ATOM   891  O  O     . LEU A 1 118 ? 166.710 138.061 123.976 1.00 49.44  ? 108 LEU A O     1 
ATOM   892  C  CB    . LEU A 1 118 ? 166.449 138.878 126.748 1.00 38.94  ? 108 LEU A CB    1 
ATOM   893  C  CG    . LEU A 1 118 ? 166.813 138.891 128.229 1.00 42.99  ? 108 LEU A CG    1 
ATOM   894  C  CD1   . LEU A 1 118 ? 165.831 138.049 129.012 1.00 41.91  ? 108 LEU A CD1   1 
ATOM   895  C  CD2   . LEU A 1 118 ? 168.225 138.387 128.432 1.00 40.62  ? 108 LEU A CD2   1 
ATOM   896  N  N     . ASN A 1 119 ? 166.888 140.263 123.537 1.00 43.40  ? 109 ASN A N     1 
ATOM   897  C  CA    . ASN A 1 119 ? 166.386 140.166 122.166 1.00 42.84  ? 109 ASN A CA    1 
ATOM   898  C  C     . ASN A 1 119 ? 164.969 139.602 122.134 1.00 41.68  ? 109 ASN A C     1 
ATOM   899  O  O     . ASN A 1 119 ? 164.602 138.848 121.235 1.00 44.64  ? 109 ASN A O     1 
ATOM   900  C  CB    . ASN A 1 119 ? 167.322 139.339 121.283 1.00 45.93  ? 109 ASN A CB    1 
ATOM   901  C  CG    . ASN A 1 119 ? 168.638 140.034 121.027 1.00 52.44  ? 109 ASN A CG    1 
ATOM   902  O  OD1   . ASN A 1 119 ? 168.701 141.261 120.966 1.00 56.49  ? 109 ASN A OD1   1 
ATOM   903  N  ND2   . ASN A 1 119 ? 169.702 139.254 120.887 1.00 51.73  ? 109 ASN A ND2   1 
ATOM   904  N  N     . ILE A 1 120 ? 164.166 139.975 123.132 1.00 36.99  ? 110 ILE A N     1 
ATOM   905  C  CA    . ILE A 1 120 ? 162.747 139.658 123.102 1.00 36.38  ? 110 ILE A CA    1 
ATOM   906  C  C     . ILE A 1 120 ? 162.099 140.401 121.945 1.00 35.40  ? 110 ILE A C     1 
ATOM   907  O  O     . ILE A 1 120 ? 162.469 141.539 121.630 1.00 39.89  ? 110 ILE A O     1 
ATOM   908  C  CB    . ILE A 1 120 ? 162.089 140.026 124.443 1.00 38.70  ? 110 ILE A CB    1 
ATOM   909  C  CG1   . ILE A 1 120 ? 162.951 139.539 125.608 1.00 37.16  ? 110 ILE A CG1   1 
ATOM   910  C  CG2   . ILE A 1 120 ? 160.671 139.472 124.524 1.00 31.98  ? 110 ILE A CG2   1 
ATOM   911  C  CD1   . ILE A 1 120 ? 162.277 139.634 126.959 1.00 30.15  ? 110 ILE A CD1   1 
ATOM   912  N  N     . GLY A 1 121 ? 161.131 139.755 121.299 1.00 34.67  ? 111 GLY A N     1 
ATOM   913  C  CA    . GLY A 1 121 ? 160.462 140.337 120.152 1.00 30.39  ? 111 GLY A CA    1 
ATOM   914  C  C     . GLY A 1 121 ? 159.840 141.683 120.448 1.00 29.55  ? 111 GLY A C     1 
ATOM   915  O  O     . GLY A 1 121 ? 159.131 141.833 121.445 1.00 32.10  ? 111 GLY A O     1 
ATOM   916  N  N     . ASN A 1 122 ? 160.095 142.667 119.580 1.00 33.52  ? 112 ASN A N     1 
ATOM   917  C  CA    . ASN A 1 122 ? 159.679 144.040 119.853 1.00 30.74  ? 112 ASN A CA    1 
ATOM   918  C  C     . ASN A 1 122 ? 158.179 144.153 120.073 1.00 29.79  ? 112 ASN A C     1 
ATOM   919  O  O     . ASN A 1 122 ? 157.730 145.041 120.802 1.00 29.64  ? 112 ASN A O     1 
ATOM   920  C  CB    . ASN A 1 122 ? 160.112 144.954 118.712 1.00 33.96  ? 112 ASN A CB    1 
ATOM   921  C  CG    . ASN A 1 122 ? 161.613 145.098 118.625 1.00 41.44  ? 112 ASN A CG    1 
ATOM   922  O  OD1   . ASN A 1 122 ? 162.336 144.698 119.537 1.00 38.62  ? 112 ASN A OD1   1 
ATOM   923  N  ND2   . ASN A 1 122 ? 162.094 145.668 117.526 1.00 42.30  ? 112 ASN A ND2   1 
ATOM   924  N  N     . THR A 1 123 ? 157.393 143.264 119.468 1.00 28.68  ? 113 THR A N     1 
ATOM   925  C  CA    . THR A 1 123 ? 155.950 143.296 119.666 1.00 21.90  ? 113 THR A CA    1 
ATOM   926  C  C     . THR A 1 123 ? 155.593 143.081 121.130 1.00 25.16  ? 113 THR A C     1 
ATOM   927  O  O     . THR A 1 123 ? 154.679 143.723 121.658 1.00 25.70  ? 113 THR A O     1 
ATOM   928  C  CB    . THR A 1 123 ? 155.286 142.234 118.793 1.00 25.58  ? 113 THR A CB    1 
ATOM   929  O  OG1   . THR A 1 123 ? 155.602 142.484 117.420 1.00 27.24  ? 113 THR A OG1   1 
ATOM   930  C  CG2   . THR A 1 123 ? 153.781 142.257 118.967 1.00 25.91  ? 113 THR A CG2   1 
ATOM   931  N  N     . PHE A 1 124 ? 156.310 142.186 121.802 1.00 25.59  ? 114 PHE A N     1 
ATOM   932  C  CA    . PHE A 1 124 ? 156.005 141.829 123.178 1.00 25.38  ? 114 PHE A CA    1 
ATOM   933  C  C     . PHE A 1 124 ? 156.690 142.720 124.200 1.00 25.08  ? 114 PHE A C     1 
ATOM   934  O  O     . PHE A 1 124 ? 156.215 142.814 125.334 1.00 31.38  ? 114 PHE A O     1 
ATOM   935  C  CB    . PHE A 1 124 ? 156.399 140.374 123.429 1.00 25.17  ? 114 PHE A CB    1 
ATOM   936  C  CG    . PHE A 1 124 ? 156.189 139.482 122.246 1.00 24.33  ? 114 PHE A CG    1 
ATOM   937  C  CD1   . PHE A 1 124 ? 154.922 139.278 121.734 1.00 24.97  ? 114 PHE A CD1   1 
ATOM   938  C  CD2   . PHE A 1 124 ? 157.257 138.853 121.642 1.00 26.47  ? 114 PHE A CD2   1 
ATOM   939  C  CE1   . PHE A 1 124 ? 154.725 138.459 120.646 1.00 24.35  ? 114 PHE A CE1   1 
ATOM   940  C  CE2   . PHE A 1 124 ? 157.068 138.038 120.555 1.00 27.35  ? 114 PHE A CE2   1 
ATOM   941  C  CZ    . PHE A 1 124 ? 155.800 137.839 120.055 1.00 22.95  ? 114 PHE A CZ    1 
ATOM   942  N  N     . PHE A 1 125 ? 157.787 143.370 123.835 1.00 22.92  ? 115 PHE A N     1 
ATOM   943  C  CA    . PHE A 1 125 ? 158.539 144.208 124.756 1.00 21.54  ? 115 PHE A CA    1 
ATOM   944  C  C     . PHE A 1 125 ? 158.171 145.679 124.649 1.00 25.25  ? 115 PHE A C     1 
ATOM   945  O  O     . PHE A 1 125 ? 158.060 146.361 125.672 1.00 23.08  ? 115 PHE A O     1 
ATOM   946  C  CB    . PHE A 1 125 ? 160.042 144.039 124.504 1.00 20.87  ? 115 PHE A CB    1 
ATOM   947  C  CG    . PHE A 1 125 ? 160.909 144.566 125.605 1.00 21.30  ? 115 PHE A CG    1 
ATOM   948  C  CD1   . PHE A 1 125 ? 161.162 143.804 126.729 1.00 23.33  ? 115 PHE A CD1   1 
ATOM   949  C  CD2   . PHE A 1 125 ? 161.486 145.816 125.511 1.00 24.31  ? 115 PHE A CD2   1 
ATOM   950  C  CE1   . PHE A 1 125 ? 161.961 144.284 127.739 1.00 20.21  ? 115 PHE A CE1   1 
ATOM   951  C  CE2   . PHE A 1 125 ? 162.291 146.301 126.523 1.00 23.10  ? 115 PHE A CE2   1 
ATOM   952  C  CZ    . PHE A 1 125 ? 162.526 145.533 127.636 1.00 18.86  ? 115 PHE A CZ    1 
ATOM   953  N  N     . ARG A 1 126 ? 157.983 146.180 123.429 1.00 24.95  ? 116 ARG A N     1 
ATOM   954  C  CA    . ARG A 1 126 ? 157.774 147.599 123.182 1.00 24.15  ? 116 ARG A CA    1 
ATOM   955  C  C     . ARG A 1 126 ? 156.309 147.942 122.928 1.00 25.10  ? 116 ARG A C     1 
ATOM   956  O  O     . ARG A 1 126 ? 155.706 148.693 123.695 1.00 29.55  ? 116 ARG A O     1 
ATOM   957  C  CB    . ARG A 1 126 ? 158.639 148.016 121.990 1.00 25.49  ? 116 ARG A CB    1 
ATOM   958  C  CG    . ARG A 1 126 ? 158.595 149.475 121.649 1.00 29.62  ? 116 ARG A CG    1 
ATOM   959  C  CD    . ARG A 1 126 ? 159.315 149.708 120.346 1.00 34.86  ? 116 ARG A CD    1 
ATOM   960  N  NE    . ARG A 1 126 ? 159.579 151.119 120.107 1.00 37.47  ? 116 ARG A NE    1 
ATOM   961  C  CZ    . ARG A 1 126 ? 160.194 151.588 119.032 1.00 41.19  ? 116 ARG A CZ    1 
ATOM   962  N  NH1   . ARG A 1 126 ? 160.619 150.782 118.074 1.00 39.23  ? 116 ARG A NH1   1 
ATOM   963  N  NH2   . ARG A 1 126 ? 160.391 152.896 118.916 1.00 44.62  ? 116 ARG A NH2   1 
ATOM   964  N  N     . GLN A 1 127 ? 155.714 147.373 121.877 1.00 28.48  ? 117 GLN A N     1 
ATOM   965  C  CA    . GLN A 1 127 ? 154.394 147.821 121.442 1.00 24.43  ? 117 GLN A CA    1 
ATOM   966  C  C     . GLN A 1 127 ? 153.300 147.358 122.393 1.00 24.75  ? 117 GLN A C     1 
ATOM   967  O  O     . GLN A 1 127 ? 152.384 148.122 122.712 1.00 29.06  ? 117 GLN A O     1 
ATOM   968  C  CB    . GLN A 1 127 ? 154.110 147.330 120.026 1.00 21.40  ? 117 GLN A CB    1 
ATOM   969  C  CG    . GLN A 1 127 ? 152.740 147.720 119.523 1.00 19.86  ? 117 GLN A CG    1 
ATOM   970  C  CD    . GLN A 1 127 ? 152.543 147.392 118.072 1.00 23.42  ? 117 GLN A CD    1 
ATOM   971  O  OE1   . GLN A 1 127 ? 153.348 146.689 117.471 1.00 29.15  ? 117 GLN A OE1   1 
ATOM   972  N  NE2   . GLN A 1 127 ? 151.474 147.907 117.491 1.00 27.59  ? 117 GLN A NE2   1 
ATOM   973  N  N     . PHE A 1 128 ? 153.364 146.110 122.842 1.00 24.45  ? 118 PHE A N     1 
ATOM   974  C  CA    . PHE A 1 128 ? 152.421 145.585 123.818 1.00 23.88  ? 118 PHE A CA    1 
ATOM   975  C  C     . PHE A 1 128 ? 153.093 145.343 125.161 1.00 27.22  ? 118 PHE A C     1 
ATOM   976  O  O     . PHE A 1 128 ? 152.697 144.456 125.916 1.00 31.78  ? 118 PHE A O     1 
ATOM   977  C  CB    . PHE A 1 128 ? 151.763 144.315 123.294 1.00 22.43  ? 118 PHE A CB    1 
ATOM   978  C  CG    . PHE A 1 128 ? 151.011 144.519 122.015 1.00 26.48  ? 118 PHE A CG    1 
ATOM   979  C  CD1   . PHE A 1 128 ? 149.722 145.013 122.028 1.00 25.21  ? 118 PHE A CD1   1 
ATOM   980  C  CD2   . PHE A 1 128 ? 151.599 144.233 120.796 1.00 20.90  ? 118 PHE A CD2   1 
ATOM   981  C  CE1   . PHE A 1 128 ? 149.037 145.213 120.854 1.00 24.46  ? 118 PHE A CE1   1 
ATOM   982  C  CE2   . PHE A 1 128 ? 150.913 144.428 119.623 1.00 18.20  ? 118 PHE A CE2   1 
ATOM   983  C  CZ    . PHE A 1 128 ? 149.634 144.919 119.651 1.00 20.16  ? 118 PHE A CZ    1 
ATOM   984  N  N     . GLY A 1 129 ? 154.134 146.115 125.448 1.00 20.83  ? 119 GLY A N     1 
ATOM   985  C  CA    . GLY A 1 129 ? 154.762 146.123 126.747 1.00 18.65  ? 119 GLY A CA    1 
ATOM   986  C  C     . GLY A 1 129 ? 154.721 147.487 127.397 1.00 23.29  ? 119 GLY A C     1 
ATOM   987  O  O     . GLY A 1 129 ? 153.673 147.946 127.867 1.00 32.25  ? 119 GLY A O     1 
ATOM   988  N  N     . TYR A 1 130 ? 155.877 148.152 127.424 1.00 25.67  ? 120 TYR A N     1 
ATOM   989  C  CA    . TYR A 1 130 ? 155.973 149.415 128.140 1.00 22.92  ? 120 TYR A CA    1 
ATOM   990  C  C     . TYR A 1 130 ? 155.125 150.497 127.486 1.00 25.24  ? 120 TYR A C     1 
ATOM   991  O  O     . TYR A 1 130 ? 154.539 151.324 128.186 1.00 29.01  ? 120 TYR A O     1 
ATOM   992  C  CB    . TYR A 1 130 ? 157.433 149.850 128.268 1.00 23.73  ? 120 TYR A CB    1 
ATOM   993  C  CG    . TYR A 1 130 ? 158.119 150.292 127.003 1.00 25.30  ? 120 TYR A CG    1 
ATOM   994  C  CD1   . TYR A 1 130 ? 157.970 151.582 126.524 1.00 28.71  ? 120 TYR A CD1   1 
ATOM   995  C  CD2   . TYR A 1 130 ? 158.964 149.438 126.318 1.00 29.65  ? 120 TYR A CD2   1 
ATOM   996  C  CE1   . TYR A 1 130 ? 158.606 151.995 125.386 1.00 31.38  ? 120 TYR A CE1   1 
ATOM   997  C  CE2   . TYR A 1 130 ? 159.612 149.849 125.174 1.00 30.81  ? 120 TYR A CE2   1 
ATOM   998  C  CZ    . TYR A 1 130 ? 159.428 151.129 124.714 1.00 32.18  ? 120 TYR A CZ    1 
ATOM   999  O  OH    . TYR A 1 130 ? 160.065 151.555 123.576 1.00 40.39  ? 120 TYR A OH    1 
ATOM   1000 N  N     . PHE A 1 131 ? 155.042 150.515 126.155 1.00 23.03  ? 121 PHE A N     1 
ATOM   1001 C  CA    . PHE A 1 131 ? 154.174 151.488 125.499 1.00 22.48  ? 121 PHE A CA    1 
ATOM   1002 C  C     . PHE A 1 131 ? 152.712 151.225 125.823 1.00 27.50  ? 121 PHE A C     1 
ATOM   1003 O  O     . PHE A 1 131 ? 151.929 152.166 126.008 1.00 35.25  ? 121 PHE A O     1 
ATOM   1004 C  CB    . PHE A 1 131 ? 154.389 151.471 123.991 1.00 23.01  ? 121 PHE A CB    1 
ATOM   1005 C  CG    . PHE A 1 131 ? 153.529 152.450 123.253 1.00 29.61  ? 121 PHE A CG    1 
ATOM   1006 C  CD1   . PHE A 1 131 ? 153.932 153.762 123.090 1.00 28.09  ? 121 PHE A CD1   1 
ATOM   1007 C  CD2   . PHE A 1 131 ? 152.306 152.060 122.738 1.00 31.00  ? 121 PHE A CD2   1 
ATOM   1008 C  CE1   . PHE A 1 131 ? 153.142 154.655 122.426 1.00 28.56  ? 121 PHE A CE1   1 
ATOM   1009 C  CE2   . PHE A 1 131 ? 151.511 152.953 122.077 1.00 32.30  ? 121 PHE A CE2   1 
ATOM   1010 C  CZ    . PHE A 1 131 ? 151.929 154.252 121.920 1.00 33.35  ? 121 PHE A CZ    1 
ATOM   1011 N  N     . LYS A 1 132 ? 152.324 149.953 125.876 1.00 23.78  ? 122 LYS A N     1 
ATOM   1012 C  CA    . LYS A 1 132 ? 150.965 149.617 126.271 1.00 24.20  ? 122 LYS A CA    1 
ATOM   1013 C  C     . LYS A 1 132 ? 150.665 150.139 127.666 1.00 24.91  ? 122 LYS A C     1 
ATOM   1014 O  O     . LYS A 1 132 ? 149.587 150.702 127.903 1.00 32.02  ? 122 LYS A O     1 
ATOM   1015 C  CB    . LYS A 1 132 ? 150.768 148.104 126.203 1.00 26.07  ? 122 LYS A CB    1 
ATOM   1016 C  CG    . LYS A 1 132 ? 149.381 147.663 125.789 1.00 28.53  ? 122 LYS A CG    1 
ATOM   1017 C  CD    . LYS A 1 132 ? 149.063 146.292 126.341 1.00 26.61  ? 122 LYS A CD    1 
ATOM   1018 C  CE    . LYS A 1 132 ? 147.830 145.699 125.689 1.00 30.38  ? 122 LYS A CE    1 
ATOM   1019 N  NZ    . LYS A 1 132 ? 146.620 146.532 125.884 1.00 32.92  ? 122 LYS A NZ    1 
ATOM   1020 N  N     . LEU A 1 133 ? 151.615 149.990 128.593 1.00 24.50  ? 123 LEU A N     1 
ATOM   1021 C  CA    . LEU A 1 133 ? 151.416 150.527 129.936 1.00 22.11  ? 123 LEU A CA    1 
ATOM   1022 C  C     . LEU A 1 133 ? 151.367 152.050 129.933 1.00 22.93  ? 123 LEU A C     1 
ATOM   1023 O  O     . LEU A 1 133 ? 150.553 152.642 130.643 1.00 29.27  ? 123 LEU A O     1 
ATOM   1024 C  CB    . LEU A 1 133 ? 152.508 150.033 130.880 1.00 28.45  ? 123 LEU A CB    1 
ATOM   1025 C  CG    . LEU A 1 133 ? 152.483 148.554 131.261 1.00 26.72  ? 123 LEU A CG    1 
ATOM   1026 C  CD1   . LEU A 1 133 ? 153.407 148.308 132.442 1.00 20.47  ? 123 LEU A CD1   1 
ATOM   1027 C  CD2   . LEU A 1 133 ? 151.065 148.082 131.555 1.00 21.18  ? 123 LEU A CD2   1 
ATOM   1028 N  N     . VAL A 1 134 ? 152.228 152.701 129.151 1.00 24.00  ? 124 VAL A N     1 
ATOM   1029 C  CA    . VAL A 1 134 ? 152.211 154.162 129.066 1.00 24.24  ? 124 VAL A CA    1 
ATOM   1030 C  C     . VAL A 1 134 ? 150.839 154.658 128.636 1.00 23.32  ? 124 VAL A C     1 
ATOM   1031 O  O     . VAL A 1 134 ? 150.287 155.599 129.218 1.00 28.52  ? 124 VAL A O     1 
ATOM   1032 C  CB    . VAL A 1 134 ? 153.303 154.665 128.106 1.00 28.02  ? 124 VAL A CB    1 
ATOM   1033 C  CG1   . VAL A 1 134 ? 153.195 156.155 127.939 1.00 30.97  ? 124 VAL A CG1   1 
ATOM   1034 C  CG2   . VAL A 1 134 ? 154.671 154.342 128.643 1.00 30.16  ? 124 VAL A CG2   1 
ATOM   1035 N  N     . VAL A 1 135 ? 150.276 154.044 127.598 1.00 22.67  ? 125 VAL A N     1 
ATOM   1036 C  CA    . VAL A 1 135 ? 148.986 154.496 127.088 1.00 22.49  ? 125 VAL A CA    1 
ATOM   1037 C  C     . VAL A 1 135 ? 147.883 154.214 128.102 1.00 23.67  ? 125 VAL A C     1 
ATOM   1038 O  O     . VAL A 1 135 ? 147.052 155.084 128.396 1.00 25.86  ? 125 VAL A O     1 
ATOM   1039 C  CB    . VAL A 1 135 ? 148.697 153.847 125.724 1.00 26.90  ? 125 VAL A CB    1 
ATOM   1040 C  CG1   . VAL A 1 135 ? 147.220 153.929 125.393 1.00 28.23  ? 125 VAL A CG1   1 
ATOM   1041 C  CG2   . VAL A 1 135 ? 149.519 154.521 124.649 1.00 21.89  ? 125 VAL A CG2   1 
ATOM   1042 N  N     . SER A 1 136 ? 147.869 153.004 128.671 1.00 26.48  ? 126 SER A N     1 
ATOM   1043 C  CA    . SER A 1 136 ? 146.860 152.664 129.667 1.00 25.10  ? 126 SER A CA    1 
ATOM   1044 C  C     . SER A 1 136 ? 146.975 153.517 130.923 1.00 24.15  ? 126 SER A C     1 
ATOM   1045 O  O     . SER A 1 136 ? 145.996 153.650 131.660 1.00 30.71  ? 126 SER A O     1 
ATOM   1046 C  CB    . SER A 1 136 ? 146.964 151.182 130.027 1.00 23.01  ? 126 SER A CB    1 
ATOM   1047 O  OG    . SER A 1 136 ? 146.162 150.857 131.147 1.00 25.01  ? 126 SER A OG    1 
ATOM   1048 N  N     . ASN A 1 137 ? 148.147 154.091 131.184 1.00 24.29  ? 127 ASN A N     1 
ATOM   1049 C  CA    . ASN A 1 137 ? 148.322 154.957 132.341 1.00 22.61  ? 127 ASN A CA    1 
ATOM   1050 C  C     . ASN A 1 137 ? 147.887 156.379 132.041 1.00 26.22  ? 127 ASN A C     1 
ATOM   1051 O  O     . ASN A 1 137 ? 147.196 157.000 132.852 1.00 34.48  ? 127 ASN A O     1 
ATOM   1052 C  CB    . ASN A 1 137 ? 149.781 154.945 132.789 1.00 23.12  ? 127 ASN A CB    1 
ATOM   1053 C  CG    . ASN A 1 137 ? 150.158 153.670 133.491 1.00 25.18  ? 127 ASN A CG    1 
ATOM   1054 O  OD1   . ASN A 1 137 ? 149.320 152.799 133.715 1.00 23.68  ? 127 ASN A OD1   1 
ATOM   1055 N  ND2   . ASN A 1 137 ? 151.427 153.545 133.837 1.00 28.46  ? 127 ASN A ND2   1 
ATOM   1056 N  N     . TYR A 1 138 ? 148.285 156.915 130.888 1.00 28.33  ? 128 TYR A N     1 
ATOM   1057 C  CA    . TYR A 1 138 ? 147.814 158.236 130.498 1.00 24.31  ? 128 TYR A CA    1 
ATOM   1058 C  C     . TYR A 1 138 ? 146.314 158.260 130.272 1.00 26.18  ? 128 TYR A C     1 
ATOM   1059 O  O     . TYR A 1 138 ? 145.725 159.342 130.243 1.00 34.43  ? 128 TYR A O     1 
ATOM   1060 C  CB    . TYR A 1 138 ? 148.530 158.711 129.242 1.00 22.79  ? 128 TYR A CB    1 
ATOM   1061 C  CG    . TYR A 1 138 ? 149.812 159.435 129.524 1.00 27.41  ? 128 TYR A CG    1 
ATOM   1062 C  CD1   . TYR A 1 138 ? 149.815 160.780 129.844 1.00 26.33  ? 128 TYR A CD1   1 
ATOM   1063 C  CD2   . TYR A 1 138 ? 151.027 158.772 129.476 1.00 31.72  ? 128 TYR A CD2   1 
ATOM   1064 C  CE1   . TYR A 1 138 ? 150.991 161.443 130.102 1.00 30.19  ? 128 TYR A CE1   1 
ATOM   1065 C  CE2   . TYR A 1 138 ? 152.207 159.428 129.734 1.00 30.60  ? 128 TYR A CE2   1 
ATOM   1066 C  CZ    . TYR A 1 138 ? 152.182 160.761 130.045 1.00 29.65  ? 128 TYR A CZ    1 
ATOM   1067 O  OH    . TYR A 1 138 ? 153.359 161.412 130.305 1.00 33.49  ? 128 TYR A OH    1 
ATOM   1068 N  N     . ARG A 1 139 ? 145.685 157.098 130.103 1.00 26.33  ? 129 ARG A N     1 
ATOM   1069 C  CA    . ARG A 1 139 ? 144.232 157.066 129.992 1.00 26.01  ? 129 ARG A CA    1 
ATOM   1070 C  C     . ARG A 1 139 ? 143.562 157.383 131.325 1.00 25.45  ? 129 ARG A C     1 
ATOM   1071 O  O     . ARG A 1 139 ? 142.631 158.191 131.379 1.00 30.85  ? 129 ARG A O     1 
ATOM   1072 C  CB    . ARG A 1 139 ? 143.777 155.708 129.461 1.00 26.30  ? 129 ARG A CB    1 
ATOM   1073 C  CG    . ARG A 1 139 ? 143.963 155.553 127.963 1.00 23.77  ? 129 ARG A CG    1 
ATOM   1074 C  CD    . ARG A 1 139 ? 143.141 154.414 127.425 1.00 21.74  ? 129 ARG A CD    1 
ATOM   1075 N  NE    . ARG A 1 139 ? 143.033 154.465 125.973 1.00 30.78  ? 129 ARG A NE    1 
ATOM   1076 C  CZ    . ARG A 1 139 ? 143.505 153.536 125.155 1.00 30.59  ? 129 ARG A CZ    1 
ATOM   1077 N  NH1   . ARG A 1 139 ? 144.116 152.459 125.613 1.00 31.79  ? 129 ARG A NH1   1 
ATOM   1078 N  NH2   . ARG A 1 139 ? 143.355 153.690 123.845 1.00 29.18  ? 129 ARG A NH2   1 
ATOM   1079 N  N     . THR A 1 140 ? 144.021 156.761 132.417 1.00 25.93  ? 130 THR A N     1 
ATOM   1080 C  CA    . THR A 1 140 ? 143.369 156.970 133.709 1.00 26.84  ? 130 THR A CA    1 
ATOM   1081 C  C     . THR A 1 140 ? 143.556 158.388 134.220 1.00 32.65  ? 130 THR A C     1 
ATOM   1082 O  O     . THR A 1 140 ? 142.681 158.912 134.914 1.00 37.74  ? 130 THR A O     1 
ATOM   1083 C  CB    . THR A 1 140 ? 143.896 155.997 134.757 1.00 20.41  ? 130 THR A CB    1 
ATOM   1084 O  OG1   . THR A 1 140 ? 145.266 156.297 135.038 1.00 20.47  ? 130 THR A OG1   1 
ATOM   1085 C  CG2   . THR A 1 140 ? 143.794 154.590 134.255 1.00 27.96  ? 130 THR A CG2   1 
ATOM   1086 N  N     . LYS A 1 141 ? 144.693 159.011 133.917 1.00 30.35  ? 131 LYS A N     1 
ATOM   1087 C  CA    . LYS A 1 141 ? 144.898 160.394 134.327 1.00 31.76  ? 131 LYS A CA    1 
ATOM   1088 C  C     . LYS A 1 141 ? 143.854 161.309 133.703 1.00 36.22  ? 131 LYS A C     1 
ATOM   1089 O  O     . LYS A 1 141 ? 143.300 162.184 134.376 1.00 46.69  ? 131 LYS A O     1 
ATOM   1090 C  CB    . LYS A 1 141 ? 146.304 160.847 133.949 1.00 27.01  ? 131 LYS A CB    1 
ATOM   1091 C  CG    . LYS A 1 141 ? 146.484 162.349 133.937 1.00 31.62  ? 131 LYS A CG    1 
ATOM   1092 C  CD    . LYS A 1 141 ? 146.301 162.932 135.323 1.00 36.23  ? 131 LYS A CD    1 
ATOM   1093 C  CE    . LYS A 1 141 ? 146.370 164.442 135.298 1.00 41.65  ? 131 LYS A CE    1 
ATOM   1094 N  NZ    . LYS A 1 141 ? 146.097 165.014 136.639 1.00 47.26  ? 131 LYS A NZ    1 
ATOM   1095 N  N     . ILE A 1 142 ? 143.555 161.109 132.428 1.00 29.63  ? 132 ILE A N     1 
ATOM   1096 C  CA    . ILE A 1 142 ? 142.675 162.021 131.718 1.00 31.34  ? 132 ILE A CA    1 
ATOM   1097 C  C     . ILE A 1 142 ? 141.207 161.629 131.858 1.00 35.44  ? 132 ILE A C     1 
ATOM   1098 O  O     . ILE A 1 142 ? 140.325 162.486 131.762 1.00 41.37  ? 132 ILE A O     1 
ATOM   1099 C  CB    . ILE A 1 142 ? 143.119 162.086 130.249 1.00 29.49  ? 132 ILE A CB    1 
ATOM   1100 C  CG1   . ILE A 1 142 ? 144.592 162.478 130.189 1.00 26.02  ? 132 ILE A CG1   1 
ATOM   1101 C  CG2   . ILE A 1 142 ? 142.288 163.074 129.460 1.00 35.00  ? 132 ILE A CG2   1 
ATOM   1102 C  CD1   . ILE A 1 142 ? 145.072 162.805 128.822 1.00 32.57  ? 132 ILE A CD1   1 
ATOM   1103 N  N     . ARG A 1 143 ? 140.919 160.354 132.099 1.00 34.27  ? 133 ARG A N     1 
ATOM   1104 C  CA    . ARG A 1 143 ? 139.533 159.929 132.232 1.00 33.65  ? 133 ARG A CA    1 
ATOM   1105 C  C     . ARG A 1 143 ? 138.965 160.244 133.606 1.00 39.21  ? 133 ARG A C     1 
ATOM   1106 O  O     . ARG A 1 143 ? 137.764 160.504 133.731 1.00 43.83  ? 133 ARG A O     1 
ATOM   1107 C  CB    . ARG A 1 143 ? 139.420 158.441 131.925 1.00 25.35  ? 133 ARG A CB    1 
ATOM   1108 C  CG    . ARG A 1 143 ? 139.638 158.166 130.466 1.00 26.59  ? 133 ARG A CG    1 
ATOM   1109 C  CD    . ARG A 1 143 ? 139.446 156.725 130.122 1.00 32.25  ? 133 ARG A CD    1 
ATOM   1110 N  NE    . ARG A 1 143 ? 139.876 156.467 128.757 1.00 27.83  ? 133 ARG A NE    1 
ATOM   1111 C  CZ    . ARG A 1 143 ? 139.678 155.326 128.120 1.00 29.44  ? 133 ARG A CZ    1 
ATOM   1112 N  NH1   . ARG A 1 143 ? 139.070 154.306 128.704 1.00 29.16  ? 133 ARG A NH1   1 
ATOM   1113 N  NH2   . ARG A 1 143 ? 140.092 155.208 126.863 1.00 34.30  ? 133 ARG A NH2   1 
ATOM   1114 N  N     . THR A 1 144 ? 139.796 160.217 134.638 1.00 39.37  ? 134 THR A N     1 
ATOM   1115 C  CA    . THR A 1 144 ? 139.405 160.697 135.951 1.00 41.09  ? 134 THR A CA    1 
ATOM   1116 C  C     . THR A 1 144 ? 139.638 162.184 136.107 1.00 47.31  ? 134 THR A C     1 
ATOM   1117 O  O     . THR A 1 144 ? 139.375 162.724 137.183 1.00 56.96  ? 134 THR A O     1 
ATOM   1118 C  CB    . THR A 1 144 ? 140.174 159.965 137.048 1.00 43.51  ? 134 THR A CB    1 
ATOM   1119 O  OG1   . THR A 1 144 ? 141.559 160.324 136.976 1.00 52.75  ? 134 THR A OG1   1 
ATOM   1120 C  CG2   . THR A 1 144 ? 140.045 158.480 136.880 1.00 33.17  ? 134 THR A CG2   1 
ATOM   1121 N  N     . LEU A 1 145 ? 140.128 162.853 135.066 1.00 46.77  ? 135 LEU A N     1 
ATOM   1122 C  CA    . LEU A 1 145 ? 140.504 164.255 135.172 1.00 52.49  ? 135 LEU A CA    1 
ATOM   1123 C  C     . LEU A 1 145 ? 139.281 165.098 135.491 1.00 62.70  ? 135 LEU A C     1 
ATOM   1124 O  O     . LEU A 1 145 ? 138.459 165.381 134.615 1.00 63.86  ? 135 LEU A O     1 
ATOM   1125 C  CB    . LEU A 1 145 ? 141.163 164.731 133.876 1.00 51.17  ? 135 LEU A CB    1 
ATOM   1126 C  CG    . LEU A 1 145 ? 142.007 166.001 133.925 1.00 52.52  ? 135 LEU A CG    1 
ATOM   1127 C  CD1   . LEU A 1 145 ? 142.993 165.954 135.077 1.00 48.66  ? 135 LEU A CD1   1 
ATOM   1128 C  CD2   . LEU A 1 145 ? 142.728 166.202 132.605 1.00 44.41  ? 135 LEU A CD2   1 
ATOM   1129 N  N     . ASN A 1 146 ? 139.164 165.502 136.750 1.00 72.46  ? 136 ASN A N     1 
ATOM   1130 C  CA    . ASN A 1 146 ? 138.047 166.306 137.227 1.00 82.55  ? 136 ASN A CA    1 
ATOM   1131 C  C     . ASN A 1 146 ? 138.538 167.743 137.291 1.00 89.68  ? 136 ASN A C     1 
ATOM   1132 O  O     . ASN A 1 146 ? 139.300 168.107 138.190 1.00 91.99  ? 136 ASN A O     1 
ATOM   1133 C  CB    . ASN A 1 146 ? 137.566 165.821 138.590 1.00 78.71  ? 136 ASN A CB    1 
ATOM   1134 C  CG    . ASN A 1 146 ? 137.146 164.362 138.579 1.00 78.69  ? 136 ASN A CG    1 
ATOM   1135 O  OD1   . ASN A 1 146 ? 136.850 163.794 137.529 1.00 75.41  ? 136 ASN A OD1   1 
ATOM   1136 N  ND2   . ASN A 1 146 ? 137.127 163.746 139.754 1.00 76.87  ? 136 ASN A ND2   1 
ATOM   1137 N  N     . CYS A 1 147 ? 138.117 168.557 136.325 1.00 90.73  ? 137 CYS A N     1 
ATOM   1138 C  CA    . CYS A 1 147 ? 138.443 169.973 136.370 1.00 95.90  ? 137 CYS A CA    1 
ATOM   1139 C  C     . CYS A 1 147 ? 137.982 170.547 137.701 1.00 109.20 ? 137 CYS A C     1 
ATOM   1140 O  O     . CYS A 1 147 ? 137.012 170.066 138.294 1.00 113.22 ? 137 CYS A O     1 
ATOM   1141 C  CB    . CYS A 1 147 ? 137.787 170.714 135.205 1.00 94.95  ? 137 CYS A CB    1 
ATOM   1142 S  SG    . CYS A 1 147 ? 135.983 170.679 135.216 1.00 115.17 ? 137 CYS A SG    1 
ATOM   1143 N  N     . GLU A 1 148 ? 138.706 171.555 138.191 1.00 110.44 ? 138 GLU A N     1 
ATOM   1144 C  CA    . GLU A 1 148 ? 138.471 172.067 139.535 1.00 109.74 ? 138 GLU A CA    1 
ATOM   1145 C  C     . GLU A 1 148 ? 137.002 172.436 139.703 1.00 115.83 ? 138 GLU A C     1 
ATOM   1146 O  O     . GLU A 1 148 ? 136.510 173.373 139.066 1.00 114.43 ? 138 GLU A O     1 
ATOM   1147 C  CB    . GLU A 1 148 ? 139.380 173.265 139.814 1.00 104.27 ? 138 GLU A CB    1 
ATOM   1148 C  CG    . GLU A 1 148 ? 139.406 173.698 141.266 1.00 106.96 ? 138 GLU A CG    1 
ATOM   1149 C  CD    . GLU A 1 148 ? 140.693 174.404 141.638 1.00 107.06 ? 138 GLU A CD    1 
ATOM   1150 O  OE1   . GLU A 1 148 ? 141.553 174.581 140.750 1.00 102.86 ? 138 GLU A OE1   1 
ATOM   1151 O  OE2   . GLU A 1 148 ? 140.850 174.775 142.820 1.00 103.57 ? 138 GLU A OE2   1 
ATOM   1152 N  N     . ILE A 1 149 ? 136.296 171.693 140.554 1.00 119.22 ? 139 ILE A N     1 
ATOM   1153 C  CA    . ILE A 1 149 ? 134.845 171.790 140.638 1.00 123.58 ? 139 ILE A CA    1 
ATOM   1154 C  C     . ILE A 1 149 ? 134.399 171.139 141.937 1.00 126.97 ? 139 ILE A C     1 
ATOM   1155 O  O     . ILE A 1 149 ? 135.089 170.274 142.484 1.00 123.16 ? 139 ILE A O     1 
ATOM   1156 C  CB    . ILE A 1 149 ? 134.175 171.133 139.403 1.00 123.98 ? 139 ILE A CB    1 
ATOM   1157 C  CG1   . ILE A 1 149 ? 132.860 171.826 139.062 1.00 127.60 ? 139 ILE A CG1   1 
ATOM   1158 C  CG2   . ILE A 1 149 ? 133.942 169.647 139.634 1.00 124.59 ? 139 ILE A CG2   1 
ATOM   1159 C  CD1   . ILE A 1 149 ? 132.353 171.468 137.690 1.00 128.25 ? 139 ILE A CD1   1 
ATOM   1160 N  N     . LYS A 1 150 ? 133.242 171.568 142.436 1.00 132.12 ? 140 LYS A N     1 
ATOM   1161 C  CA    . LYS A 1 150 ? 132.658 171.024 143.652 1.00 132.31 ? 140 LYS A CA    1 
ATOM   1162 C  C     . LYS A 1 150 ? 131.162 170.855 143.430 1.00 134.32 ? 140 LYS A C     1 
ATOM   1163 O  O     . LYS A 1 150 ? 130.642 171.116 142.341 1.00 134.30 ? 140 LYS A O     1 
ATOM   1164 C  CB    . LYS A 1 150 ? 132.947 171.926 144.858 1.00 128.46 ? 140 LYS A CB    1 
ATOM   1165 C  CG    . LYS A 1 150 ? 134.427 172.069 145.189 1.00 117.82 ? 140 LYS A CG    1 
ATOM   1166 C  CD    . LYS A 1 150 ? 134.698 173.341 145.975 1.00 110.66 ? 140 LYS A CD    1 
ATOM   1167 C  CE    . LYS A 1 150 ? 136.173 173.478 146.308 1.00 103.69 ? 140 LYS A CE    1 
ATOM   1168 N  NZ    . LYS A 1 150 ? 136.445 174.688 147.133 1.00 99.22  ? 140 LYS A NZ    1 
ATOM   1169 N  N     . ARG A 1 151 ? 130.463 170.412 144.470 1.00 135.67 ? 141 ARG A N     1 
ATOM   1170 C  CA    . ARG A 1 151 ? 129.021 170.219 144.420 1.00 136.64 ? 141 ARG A CA    1 
ATOM   1171 C  C     . ARG A 1 151 ? 128.351 171.188 145.383 1.00 134.33 ? 141 ARG A C     1 
ATOM   1172 O  O     . ARG A 1 151 ? 128.730 171.268 146.556 1.00 128.66 ? 141 ARG A O     1 
ATOM   1173 C  CB    . ARG A 1 151 ? 128.642 168.778 144.764 1.00 134.66 ? 141 ARG A CB    1 
ATOM   1174 C  CG    . ARG A 1 151 ? 127.206 168.413 144.405 1.00 134.97 ? 141 ARG A CG    1 
ATOM   1175 C  CD    . ARG A 1 151 ? 127.005 166.907 144.419 1.00 135.92 ? 141 ARG A CD    1 
ATOM   1176 N  NE    . ARG A 1 151 ? 125.738 166.510 143.816 1.00 137.45 ? 141 ARG A NE    1 
ATOM   1177 C  CZ    . ARG A 1 151 ? 125.418 165.260 143.509 1.00 137.43 ? 141 ARG A CZ    1 
ATOM   1178 N  NH1   . ARG A 1 151 ? 126.246 164.256 143.748 1.00 134.57 ? 141 ARG A NH1   1 
ATOM   1179 N  NH2   . ARG A 1 151 ? 124.240 165.012 142.944 1.00 139.24 ? 141 ARG A NH2   1 
ATOM   1180 N  N     . LYS A 1 152 ? 127.361 171.922 144.881 1.00 135.08 ? 142 LYS A N     1 
ATOM   1181 C  CA    . LYS A 1 152 ? 126.627 172.894 145.673 1.00 135.97 ? 142 LYS A CA    1 
ATOM   1182 C  C     . LYS A 1 152 ? 125.153 172.809 145.305 1.00 139.22 ? 142 LYS A C     1 
ATOM   1183 O  O     . LYS A 1 152 ? 124.801 172.435 144.184 1.00 138.45 ? 142 LYS A O     1 
ATOM   1184 C  CB    . LYS A 1 152 ? 127.167 174.315 145.441 1.00 134.52 ? 142 LYS A CB    1 
ATOM   1185 C  CG    . LYS A 1 152 ? 126.566 175.388 146.334 1.00 134.36 ? 142 LYS A CG    1 
ATOM   1186 C  CD    . LYS A 1 152 ? 127.122 176.758 145.983 1.00 136.05 ? 142 LYS A CD    1 
ATOM   1187 C  CE    . LYS A 1 152 ? 126.558 177.837 146.891 1.00 135.38 ? 142 LYS A CE    1 
ATOM   1188 N  NZ    . LYS A 1 152 ? 127.138 179.174 146.588 1.00 134.15 ? 142 LYS A NZ    1 
ATOM   1189 N  N     . LYS A 1 153 ? 124.293 173.142 146.264 1.00 139.18 ? 143 LYS A N     1 
ATOM   1190 C  CA    . LYS A 1 153 ? 122.859 173.147 146.007 1.00 140.96 ? 143 LYS A CA    1 
ATOM   1191 C  C     . LYS A 1 153 ? 122.498 174.306 145.086 1.00 143.87 ? 143 LYS A C     1 
ATOM   1192 O  O     . LYS A 1 153 ? 122.940 175.439 145.294 1.00 142.86 ? 143 LYS A O     1 
ATOM   1193 C  CB    . LYS A 1 153 ? 122.082 173.247 147.318 1.00 137.25 ? 143 LYS A CB    1 
ATOM   1194 C  CG    . LYS A 1 153 ? 122.177 172.005 148.191 1.00 131.65 ? 143 LYS A CG    1 
ATOM   1195 C  CD    . LYS A 1 153 ? 121.008 171.912 149.163 1.00 125.13 ? 143 LYS A CD    1 
ATOM   1196 C  CE    . LYS A 1 153 ? 121.045 170.607 149.942 1.00 114.20 ? 143 LYS A CE    1 
ATOM   1197 N  NZ    . LYS A 1 153 ? 119.833 170.421 150.787 1.00 105.56 ? 143 LYS A NZ    1 
ATOM   1198 N  N     . ILE A 1 154 ? 121.692 174.021 144.068 1.00 143.95 ? 144 ILE A N     1 
ATOM   1199 C  CA    . ILE A 1 154 ? 121.277 175.031 143.102 1.00 145.88 ? 144 ILE A CA    1 
ATOM   1200 C  C     . ILE A 1 154 ? 120.043 175.742 143.638 1.00 146.72 ? 144 ILE A C     1 
ATOM   1201 O  O     . ILE A 1 154 ? 119.003 175.114 143.867 1.00 143.57 ? 144 ILE A O     1 
ATOM   1202 C  CB    . ILE A 1 154 ? 120.996 174.409 141.726 1.00 145.82 ? 144 ILE A CB    1 
ATOM   1203 C  CG1   . ILE A 1 154 ? 122.239 173.698 141.197 1.00 144.19 ? 144 ILE A CG1   1 
ATOM   1204 C  CG2   . ILE A 1 154 ? 120.537 175.480 140.744 1.00 145.42 ? 144 ILE A CG2   1 
ATOM   1205 C  CD1   . ILE A 1 154 ? 122.157 173.356 139.729 1.00 144.29 ? 144 ILE A CD1   1 
ATOM   1206 N  N     . ASP A 1 155 ? 120.155 177.052 143.829 1.00 149.29 ? 145 ASP A N     1 
ATOM   1207 C  CA    . ASP A 1 155 ? 119.056 177.889 144.278 1.00 149.43 ? 145 ASP A CA    1 
ATOM   1208 C  C     . ASP A 1 155 ? 118.579 178.777 143.136 1.00 150.01 ? 145 ASP A C     1 
ATOM   1209 O  O     . ASP A 1 155 ? 119.264 178.945 142.122 1.00 147.72 ? 145 ASP A O     1 
ATOM   1210 C  CB    . ASP A 1 155 ? 119.475 178.751 145.475 1.00 148.06 ? 145 ASP A CB    1 
ATOM   1211 C  CG    . ASP A 1 155 ? 119.793 177.923 146.706 1.00 147.43 ? 145 ASP A CG    1 
ATOM   1212 O  OD1   . ASP A 1 155 ? 119.470 176.716 146.711 1.00 146.97 ? 145 ASP A OD1   1 
ATOM   1213 O  OD2   . ASP A 1 155 ? 120.361 178.481 147.668 1.00 145.08 ? 145 ASP A OD2   1 
ATOM   1214 N  N     . ALA A 1 156 ? 117.379 179.337 143.308 1.00 151.90 ? 146 ALA A N     1 
ATOM   1215 C  CA    . ALA A 1 156 ? 116.839 180.241 142.298 1.00 150.56 ? 146 ALA A CA    1 
ATOM   1216 C  C     . ALA A 1 156 ? 117.712 181.480 142.149 1.00 150.43 ? 146 ALA A C     1 
ATOM   1217 O  O     . ALA A 1 156 ? 117.983 181.927 141.028 1.00 149.78 ? 146 ALA A O     1 
ATOM   1218 C  CB    . ALA A 1 156 ? 115.405 180.632 142.651 1.00 145.74 ? 146 ALA A CB    1 
ATOM   1219 N  N     . ASP A 1 157 ? 118.164 182.048 143.266 1.00 148.66 ? 147 ASP A N     1 
ATOM   1220 C  CA    . ASP A 1 157 ? 119.099 183.171 143.244 1.00 147.10 ? 147 ASP A CA    1 
ATOM   1221 C  C     . ASP A 1 157 ? 120.506 182.615 143.440 1.00 147.07 ? 147 ASP A C     1 
ATOM   1222 O  O     . ASP A 1 157 ? 121.111 182.722 144.507 1.00 144.49 ? 147 ASP A O     1 
ATOM   1223 C  CB    . ASP A 1 157 ? 118.738 184.207 144.304 1.00 143.64 ? 147 ASP A CB    1 
ATOM   1224 C  CG    . ASP A 1 157 ? 117.533 185.041 143.916 1.00 141.43 ? 147 ASP A CG    1 
ATOM   1225 O  OD1   . ASP A 1 157 ? 117.151 185.019 142.728 1.00 141.88 ? 147 ASP A OD1   1 
ATOM   1226 O  OD2   . ASP A 1 157 ? 116.970 185.723 144.798 1.00 139.13 ? 147 ASP A OD2   1 
ATOM   1227 N  N     . SER A 1 158 ? 121.025 182.007 142.378 1.00 148.58 ? 148 SER A N     1 
ATOM   1228 C  CA    . SER A 1 158 ? 122.393 181.517 142.343 1.00 149.16 ? 148 SER A CA    1 
ATOM   1229 C  C     . SER A 1 158 ? 123.093 182.105 141.128 1.00 149.96 ? 148 SER A C     1 
ATOM   1230 O  O     . SER A 1 158 ? 122.483 182.294 140.072 1.00 146.74 ? 148 SER A O     1 
ATOM   1231 C  CB    . SER A 1 158 ? 122.450 179.980 142.302 1.00 146.51 ? 148 SER A CB    1 
ATOM   1232 O  OG    . SER A 1 158 ? 121.761 179.467 141.177 1.00 143.79 ? 148 SER A OG    1 
ATOM   1233 N  N     . THR A 1 159 ? 124.382 182.397 141.291 1.00 150.08 ? 149 THR A N     1 
ATOM   1234 C  CA    . THR A 1 159 ? 125.156 183.030 140.236 1.00 148.46 ? 149 THR A CA    1 
ATOM   1235 C  C     . THR A 1 159 ? 125.324 182.084 139.047 1.00 144.50 ? 149 THR A C     1 
ATOM   1236 O  O     . THR A 1 159 ? 125.006 180.892 139.107 1.00 142.03 ? 149 THR A O     1 
ATOM   1237 C  CB    . THR A 1 159 ? 126.524 183.464 140.760 1.00 149.58 ? 149 THR A CB    1 
ATOM   1238 O  OG1   . THR A 1 159 ? 127.348 182.310 140.968 1.00 148.43 ? 149 THR A OG1   1 
ATOM   1239 C  CG2   . THR A 1 159 ? 126.378 184.224 142.074 1.00 146.07 ? 149 THR A CG2   1 
ATOM   1240 N  N     . SER A 1 160 ? 125.830 182.642 137.943 1.00 142.05 ? 150 SER A N     1 
ATOM   1241 C  CA    . SER A 1 160 ? 126.051 181.842 136.743 1.00 140.37 ? 150 SER A CA    1 
ATOM   1242 C  C     . SER A 1 160 ? 127.037 180.711 136.999 1.00 141.21 ? 150 SER A C     1 
ATOM   1243 O  O     . SER A 1 160 ? 126.913 179.634 136.405 1.00 138.09 ? 150 SER A O     1 
ATOM   1244 C  CB    . SER A 1 160 ? 126.545 182.730 135.601 1.00 134.32 ? 150 SER A CB    1 
ATOM   1245 O  OG    . SER A 1 160 ? 125.572 183.699 135.250 1.00 126.87 ? 150 SER A OG    1 
ATOM   1246 N  N     . GLU A 1 161 ? 128.018 180.934 137.876 1.00 143.60 ? 151 GLU A N     1 
ATOM   1247 C  CA    . GLU A 1 161 ? 128.967 179.877 138.209 1.00 142.73 ? 151 GLU A CA    1 
ATOM   1248 C  C     . GLU A 1 161 ? 128.267 178.694 138.868 1.00 144.23 ? 151 GLU A C     1 
ATOM   1249 O  O     . GLU A 1 161 ? 128.557 177.536 138.546 1.00 144.46 ? 151 GLU A O     1 
ATOM   1250 C  CB    . GLU A 1 161 ? 130.067 180.426 139.119 1.00 140.99 ? 151 GLU A CB    1 
ATOM   1251 C  CG    . GLU A 1 161 ? 131.011 181.411 138.443 1.00 141.67 ? 151 GLU A CG    1 
ATOM   1252 C  CD    . GLU A 1 161 ? 130.437 182.812 138.355 1.00 143.02 ? 151 GLU A CD    1 
ATOM   1253 O  OE1   . GLU A 1 161 ? 129.646 183.189 139.243 1.00 145.73 ? 151 GLU A OE1   1 
ATOM   1254 O  OE2   . GLU A 1 161 ? 130.778 183.534 137.395 1.00 139.47 ? 151 GLU A OE2   1 
ATOM   1255 N  N     . ASP A 1 162 ? 127.338 178.964 139.788 1.00 145.25 ? 152 ASP A N     1 
ATOM   1256 C  CA    . ASP A 1 162 ? 126.621 177.880 140.454 1.00 143.83 ? 152 ASP A CA    1 
ATOM   1257 C  C     . ASP A 1 162 ? 125.783 177.080 139.462 1.00 142.42 ? 152 ASP A C     1 
ATOM   1258 O  O     . ASP A 1 162 ? 125.651 175.857 139.594 1.00 141.91 ? 152 ASP A O     1 
ATOM   1259 C  CB    . ASP A 1 162 ? 125.748 178.440 141.577 1.00 145.12 ? 152 ASP A CB    1 
ATOM   1260 C  CG    . ASP A 1 162 ? 126.566 179.007 142.723 1.00 143.74 ? 152 ASP A CG    1 
ATOM   1261 O  OD1   . ASP A 1 162 ? 127.747 178.623 142.858 1.00 142.40 ? 152 ASP A OD1   1 
ATOM   1262 O  OD2   . ASP A 1 162 ? 126.031 179.836 143.488 1.00 140.49 ? 152 ASP A OD2   1 
ATOM   1263 N  N     . ILE A 1 163 ? 125.198 177.754 138.470 1.00 142.18 ? 153 ILE A N     1 
ATOM   1264 C  CA    . ILE A 1 163 ? 124.500 177.045 137.402 1.00 140.15 ? 153 ILE A CA    1 
ATOM   1265 C  C     . ILE A 1 163 ? 125.478 176.182 136.615 1.00 141.24 ? 153 ILE A C     1 
ATOM   1266 O  O     . ILE A 1 163 ? 125.223 175.000 136.353 1.00 143.85 ? 153 ILE A O     1 
ATOM   1267 C  CB    . ILE A 1 163 ? 123.766 178.042 136.485 1.00 135.40 ? 153 ILE A CB    1 
ATOM   1268 C  CG1   . ILE A 1 163 ? 122.434 178.466 137.108 1.00 130.98 ? 153 ILE A CG1   1 
ATOM   1269 C  CG2   . ILE A 1 163 ? 123.551 177.449 135.101 1.00 132.22 ? 153 ILE A CG2   1 
ATOM   1270 C  CD1   . ILE A 1 163 ? 121.646 179.439 136.258 1.00 122.43 ? 153 ILE A CD1   1 
ATOM   1271 N  N     . GLU A 1 164 ? 126.623 176.755 136.243 1.00 138.74 ? 154 GLU A N     1 
ATOM   1272 C  CA    . GLU A 1 164 ? 127.560 176.050 135.377 1.00 138.44 ? 154 GLU A CA    1 
ATOM   1273 C  C     . GLU A 1 164 ? 128.353 174.980 136.118 1.00 136.97 ? 154 GLU A C     1 
ATOM   1274 O  O     . GLU A 1 164 ? 128.664 173.937 135.532 1.00 134.55 ? 154 GLU A O     1 
ATOM   1275 C  CB    . GLU A 1 164 ? 128.507 177.053 134.710 1.00 135.63 ? 154 GLU A CB    1 
ATOM   1276 C  CG    . GLU A 1 164 ? 129.511 176.439 133.738 1.00 133.12 ? 154 GLU A CG    1 
ATOM   1277 C  CD    . GLU A 1 164 ? 128.868 175.828 132.500 1.00 135.89 ? 154 GLU A CD    1 
ATOM   1278 O  OE1   . GLU A 1 164 ? 127.640 175.960 132.317 1.00 135.17 ? 154 GLU A OE1   1 
ATOM   1279 O  OE2   . GLU A 1 164 ? 129.602 175.204 131.704 1.00 134.96 ? 154 GLU A OE2   1 
ATOM   1280 N  N     . MET A 1 165 ? 128.691 175.208 137.389 1.00 138.71 ? 155 MET A N     1 
ATOM   1281 C  CA    . MET A 1 165 ? 129.483 174.226 138.125 1.00 139.40 ? 155 MET A CA    1 
ATOM   1282 C  C     . MET A 1 165 ? 128.747 172.897 138.238 1.00 137.42 ? 155 MET A C     1 
ATOM   1283 O  O     . MET A 1 165 ? 129.287 171.844 137.884 1.00 136.22 ? 155 MET A O     1 
ATOM   1284 C  CB    . MET A 1 165 ? 129.841 174.763 139.511 1.00 141.25 ? 155 MET A CB    1 
ATOM   1285 C  CG    . MET A 1 165 ? 130.998 175.750 139.521 1.00 143.01 ? 155 MET A CG    1 
ATOM   1286 S  SD    . MET A 1 165 ? 131.257 176.504 141.140 1.00 146.56 ? 155 MET A SD    1 
ATOM   1287 C  CE    . MET A 1 165 ? 131.141 175.070 142.208 1.00 134.43 ? 155 MET A CE    1 
ATOM   1288 N  N     . GLN A 1 166 ? 127.502 172.924 138.717 1.00 137.87 ? 156 GLN A N     1 
ATOM   1289 C  CA    . GLN A 1 166 ? 126.734 171.688 138.809 1.00 137.19 ? 156 GLN A CA    1 
ATOM   1290 C  C     . GLN A 1 166 ? 126.429 171.099 137.440 1.00 136.92 ? 156 GLN A C     1 
ATOM   1291 O  O     . GLN A 1 166 ? 126.177 169.894 137.340 1.00 136.34 ? 156 GLN A O     1 
ATOM   1292 C  CB    . GLN A 1 166 ? 125.440 171.929 139.585 1.00 140.41 ? 156 GLN A CB    1 
ATOM   1293 C  CG    . GLN A 1 166 ? 125.651 172.602 140.931 1.00 140.83 ? 156 GLN A CG    1 
ATOM   1294 C  CD    . GLN A 1 166 ? 126.803 171.996 141.708 1.00 137.80 ? 156 GLN A CD    1 
ATOM   1295 O  OE1   . GLN A 1 166 ? 126.828 170.792 141.963 1.00 134.88 ? 156 GLN A OE1   1 
ATOM   1296 N  NE2   . GLN A 1 166 ? 127.769 172.828 142.082 1.00 136.78 ? 156 GLN A NE2   1 
ATOM   1297 N  N     . THR A 1 167 ? 126.437 171.921 136.389 1.00 137.91 ? 157 THR A N     1 
ATOM   1298 C  CA    . THR A 1 167 ? 126.331 171.396 135.032 1.00 138.29 ? 157 THR A CA    1 
ATOM   1299 C  C     . THR A 1 167 ? 127.526 170.511 134.701 1.00 138.70 ? 157 THR A C     1 
ATOM   1300 O  O     . THR A 1 167 ? 127.384 169.303 134.486 1.00 135.67 ? 157 THR A O     1 
ATOM   1301 C  CB    . THR A 1 167 ? 126.226 172.547 134.030 1.00 136.67 ? 157 THR A CB    1 
ATOM   1302 O  OG1   . THR A 1 167 ? 125.160 173.424 134.413 1.00 141.87 ? 157 THR A OG1   1 
ATOM   1303 C  CG2   . THR A 1 167 ? 125.969 172.017 132.628 1.00 133.29 ? 157 THR A CG2   1 
ATOM   1304 N  N     . MET A 1 168 ? 128.723 171.102 134.682 1.00 138.00 ? 158 MET A N     1 
ATOM   1305 C  CA    . MET A 1 168 ? 129.920 170.362 134.300 1.00 131.97 ? 158 MET A CA    1 
ATOM   1306 C  C     . MET A 1 168 ? 130.242 169.251 135.289 1.00 132.08 ? 158 MET A C     1 
ATOM   1307 O  O     . MET A 1 168 ? 130.812 168.226 134.900 1.00 131.97 ? 158 MET A O     1 
ATOM   1308 C  CB    . MET A 1 168 ? 131.102 171.321 134.173 1.00 128.82 ? 158 MET A CB    1 
ATOM   1309 C  CG    . MET A 1 168 ? 130.876 172.446 133.181 1.00 127.98 ? 158 MET A CG    1 
ATOM   1310 S  SD    . MET A 1 168 ? 132.142 173.724 133.285 1.00 122.50 ? 158 MET A SD    1 
ATOM   1311 C  CE    . MET A 1 168 ? 132.044 174.141 135.023 1.00 125.93 ? 158 MET A CE    1 
ATOM   1312 N  N     . TYR A 1 169 ? 129.893 169.436 136.565 1.00 134.14 ? 159 TYR A N     1 
ATOM   1313 C  CA    . TYR A 1 169 ? 130.174 168.411 137.565 1.00 135.45 ? 159 TYR A CA    1 
ATOM   1314 C  C     . TYR A 1 169 ? 129.460 167.110 137.227 1.00 137.11 ? 159 TYR A C     1 
ATOM   1315 O  O     . TYR A 1 169 ? 130.043 166.026 137.340 1.00 137.03 ? 159 TYR A O     1 
ATOM   1316 C  CB    . TYR A 1 169 ? 129.768 168.912 138.954 1.00 136.12 ? 159 TYR A CB    1 
ATOM   1317 C  CG    . TYR A 1 169 ? 129.970 167.926 140.089 1.00 138.65 ? 159 TYR A CG    1 
ATOM   1318 C  CD1   . TYR A 1 169 ? 129.028 166.939 140.361 1.00 137.38 ? 159 TYR A CD1   1 
ATOM   1319 C  CD2   . TYR A 1 169 ? 131.092 167.998 140.905 1.00 136.91 ? 159 TYR A CD2   1 
ATOM   1320 C  CE1   . TYR A 1 169 ? 129.205 166.043 141.399 1.00 136.98 ? 159 TYR A CE1   1 
ATOM   1321 C  CE2   . TYR A 1 169 ? 131.278 167.104 141.947 1.00 137.02 ? 159 TYR A CE2   1 
ATOM   1322 C  CZ    . TYR A 1 169 ? 130.329 166.130 142.189 1.00 135.58 ? 159 TYR A CZ    1 
ATOM   1323 O  OH    . TYR A 1 169 ? 130.503 165.239 143.223 1.00 127.54 ? 159 TYR A OH    1 
ATOM   1324 N  N     . GLU A 1 170 ? 128.198 167.195 136.810 1.00 138.76 ? 160 GLU A N     1 
ATOM   1325 C  CA    . GLU A 1 170 ? 127.458 165.995 136.442 1.00 138.65 ? 160 GLU A CA    1 
ATOM   1326 C  C     . GLU A 1 170 ? 127.853 165.475 135.065 1.00 134.05 ? 160 GLU A C     1 
ATOM   1327 O  O     . GLU A 1 170 ? 127.758 164.268 134.817 1.00 132.98 ? 160 GLU A O     1 
ATOM   1328 C  CB    . GLU A 1 170 ? 125.955 166.271 136.499 1.00 135.55 ? 160 GLU A CB    1 
ATOM   1329 C  CG    . GLU A 1 170 ? 125.437 166.616 137.891 1.00 136.42 ? 160 GLU A CG    1 
ATOM   1330 C  CD    . GLU A 1 170 ? 125.623 165.497 138.916 1.00 139.80 ? 160 GLU A CD    1 
ATOM   1331 O  OE1   . GLU A 1 170 ? 125.960 164.357 138.532 1.00 137.95 ? 160 GLU A OE1   1 
ATOM   1332 O  OE2   . GLU A 1 170 ? 125.424 165.762 140.120 1.00 139.72 ? 160 GLU A OE2   1 
ATOM   1333 N  N     . ILE A 1 171 ? 128.290 166.359 134.164 1.00 130.52 ? 161 ILE A N     1 
ATOM   1334 C  CA    . ILE A 1 171 ? 128.746 165.915 132.849 1.00 130.84 ? 161 ILE A CA    1 
ATOM   1335 C  C     . ILE A 1 171 ? 129.955 165.002 132.986 1.00 134.59 ? 161 ILE A C     1 
ATOM   1336 O  O     . ILE A 1 171 ? 130.034 163.949 132.342 1.00 132.95 ? 161 ILE A O     1 
ATOM   1337 C  CB    . ILE A 1 171 ? 129.061 167.125 131.951 1.00 129.41 ? 161 ILE A CB    1 
ATOM   1338 C  CG1   . ILE A 1 171 ? 127.822 167.993 131.761 1.00 130.75 ? 161 ILE A CG1   1 
ATOM   1339 C  CG2   . ILE A 1 171 ? 129.609 166.671 130.609 1.00 122.98 ? 161 ILE A CG2   1 
ATOM   1340 C  CD1   . ILE A 1 171 ? 128.108 169.296 131.063 1.00 132.23 ? 161 ILE A CD1   1 
ATOM   1341 N  N     . ILE A 1 172 ? 130.916 165.392 133.826 1.00 135.15 ? 162 ILE A N     1 
ATOM   1342 C  CA    . ILE A 1 172 ? 132.113 164.583 134.032 1.00 128.18 ? 162 ILE A CA    1 
ATOM   1343 C  C     . ILE A 1 172 ? 131.753 163.238 134.645 1.00 129.31 ? 162 ILE A C     1 
ATOM   1344 O  O     . ILE A 1 172 ? 132.287 162.194 134.249 1.00 124.74 ? 162 ILE A O     1 
ATOM   1345 C  CB    . ILE A 1 172 ? 133.122 165.351 134.902 1.00 121.43 ? 162 ILE A CB    1 
ATOM   1346 C  CG1   . ILE A 1 172 ? 133.631 166.582 134.152 1.00 117.43 ? 162 ILE A CG1   1 
ATOM   1347 C  CG2   . ILE A 1 172 ? 134.263 164.448 135.318 1.00 120.77 ? 162 ILE A CG2   1 
ATOM   1348 C  CD1   . ILE A 1 172 ? 134.387 167.547 135.026 1.00 110.46 ? 162 ILE A CD1   1 
ATOM   1349 N  N     . LYS A 1 173 ? 130.841 163.239 135.619 1.00 132.18 ? 163 LYS A N     1 
ATOM   1350 C  CA    . LYS A 1 173 ? 130.430 161.995 136.258 1.00 134.23 ? 163 LYS A CA    1 
ATOM   1351 C  C     . LYS A 1 173 ? 129.697 161.061 135.305 1.00 134.46 ? 163 LYS A C     1 
ATOM   1352 O  O     . LYS A 1 173 ? 129.514 159.884 135.635 1.00 134.91 ? 163 LYS A O     1 
ATOM   1353 C  CB    . LYS A 1 173 ? 129.541 162.291 137.467 1.00 132.13 ? 163 LYS A CB    1 
ATOM   1354 C  CG    . LYS A 1 173 ? 130.218 163.081 138.578 1.00 134.29 ? 163 LYS A CG    1 
ATOM   1355 C  CD    . LYS A 1 173 ? 131.538 162.452 138.999 1.00 132.31 ? 163 LYS A CD    1 
ATOM   1356 C  CE    . LYS A 1 173 ? 132.235 163.294 140.060 1.00 129.61 ? 163 LYS A CE    1 
ATOM   1357 N  NZ    . LYS A 1 173 ? 133.498 162.669 140.547 1.00 121.05 ? 163 LYS A NZ    1 
ATOM   1358 N  N     . HIS A 1 174 ? 129.267 161.549 134.141 1.00 132.85 ? 164 HIS A N     1 
ATOM   1359 C  CA    . HIS A 1 174 ? 128.466 160.744 133.235 1.00 131.75 ? 164 HIS A CA    1 
ATOM   1360 C  C     . HIS A 1 174 ? 128.847 160.875 131.767 1.00 131.38 ? 164 HIS A C     1 
ATOM   1361 O  O     . HIS A 1 174 ? 128.223 160.214 130.929 1.00 132.87 ? 164 HIS A O     1 
ATOM   1362 C  CB    . HIS A 1 174 ? 126.979 161.086 133.416 1.00 133.04 ? 164 HIS A CB    1 
ATOM   1363 C  CG    . HIS A 1 174 ? 126.448 160.718 134.767 1.00 140.02 ? 164 HIS A CG    1 
ATOM   1364 N  ND1   . HIS A 1 174 ? 126.502 161.574 135.845 1.00 141.90 ? 164 HIS A ND1   1 
ATOM   1365 C  CD2   . HIS A 1 174 ? 125.877 159.577 135.221 1.00 140.46 ? 164 HIS A CD2   1 
ATOM   1366 C  CE1   . HIS A 1 174 ? 125.976 160.981 136.902 1.00 142.01 ? 164 HIS A CE1   1 
ATOM   1367 N  NE2   . HIS A 1 174 ? 125.589 159.768 136.550 1.00 141.20 ? 164 HIS A NE2   1 
ATOM   1368 N  N     . ASN A 1 175 ? 129.842 161.700 131.431 1.00 132.41 ? 165 ASN A N     1 
ATOM   1369 C  CA    . ASN A 1 175 ? 130.397 161.784 130.077 1.00 127.79 ? 165 ASN A CA    1 
ATOM   1370 C  C     . ASN A 1 175 ? 129.335 162.110 129.031 1.00 127.76 ? 165 ASN A C     1 
ATOM   1371 O  O     . ASN A 1 175 ? 129.423 161.666 127.884 1.00 125.11 ? 165 ASN A O     1 
ATOM   1372 C  CB    . ASN A 1 175 ? 131.132 160.494 129.699 1.00 118.87 ? 165 ASN A CB    1 
ATOM   1373 C  CG    . ASN A 1 175 ? 132.619 160.569 129.976 1.00 111.83 ? 165 ASN A CG    1 
ATOM   1374 O  OD1   . ASN A 1 175 ? 133.127 161.588 130.442 1.00 108.85 ? 165 ASN A OD1   1 
ATOM   1375 N  ND2   . ASN A 1 175 ? 133.328 159.487 129.686 1.00 105.07 ? 165 ASN A ND2   1 
ATOM   1376 N  N     . LEU A 1 176 ? 128.330 162.895 129.410 1.00 132.56 ? 166 LEU A N     1 
ATOM   1377 C  CA    . LEU A 1 176 ? 127.252 163.241 128.495 1.00 133.29 ? 166 LEU A CA    1 
ATOM   1378 C  C     . LEU A 1 176 ? 127.657 164.427 127.631 1.00 131.15 ? 166 LEU A C     1 
ATOM   1379 O  O     . LEU A 1 176 ? 128.043 165.479 128.147 1.00 133.64 ? 166 LEU A O     1 
ATOM   1380 C  CB    . LEU A 1 176 ? 125.976 163.562 129.272 1.00 135.75 ? 166 LEU A CB    1 
ATOM   1381 C  CG    . LEU A 1 176 ? 125.465 162.460 130.199 1.00 135.00 ? 166 LEU A CG    1 
ATOM   1382 C  CD1   . LEU A 1 176 ? 124.108 162.833 130.772 1.00 136.20 ? 166 LEU A CD1   1 
ATOM   1383 C  CD2   . LEU A 1 176 ? 125.395 161.134 129.461 1.00 132.57 ? 166 LEU A CD2   1 
ATOM   1384 N  N     . ASN A 1 177 ? 127.572 164.255 126.316 1.00 130.06 ? 167 ASN A N     1 
ATOM   1385 C  CA    . ASN A 1 177 ? 127.934 165.307 125.375 1.00 130.87 ? 167 ASN A CA    1 
ATOM   1386 C  C     . ASN A 1 177 ? 126.768 165.749 124.508 1.00 135.23 ? 167 ASN A C     1 
ATOM   1387 O  O     . ASN A 1 177 ? 126.476 166.948 124.437 1.00 137.24 ? 167 ASN A O     1 
ATOM   1388 C  CB    . ASN A 1 177 ? 129.101 164.834 124.498 1.00 124.79 ? 167 ASN A CB    1 
ATOM   1389 C  CG    . ASN A 1 177 ? 130.224 164.224 125.311 1.00 120.23 ? 167 ASN A CG    1 
ATOM   1390 O  OD1   . ASN A 1 177 ? 131.043 164.936 125.894 1.00 112.82 ? 167 ASN A OD1   1 
ATOM   1391 N  ND2   . ASN A 1 177 ? 130.256 162.899 125.373 1.00 113.89 ? 167 ASN A ND2   1 
ATOM   1392 N  N     . LYS A 1 178 ? 126.084 164.818 123.851 1.00 137.13 ? 168 LYS A N     1 
ATOM   1393 C  CA    . LYS A 1 178 ? 124.988 165.190 122.971 1.00 139.44 ? 168 LYS A CA    1 
ATOM   1394 C  C     . LYS A 1 178 ? 123.777 165.653 123.779 1.00 142.18 ? 168 LYS A C     1 
ATOM   1395 O  O     . LYS A 1 178 ? 123.688 165.454 124.993 1.00 143.55 ? 168 LYS A O     1 
ATOM   1396 C  CB    . LYS A 1 178 ? 124.601 164.019 122.068 1.00 137.47 ? 168 LYS A CB    1 
ATOM   1397 C  CG    . LYS A 1 178 ? 125.634 163.681 121.003 1.00 128.72 ? 168 LYS A CG    1 
ATOM   1398 C  CD    . LYS A 1 178 ? 125.161 162.523 120.135 1.00 124.23 ? 168 LYS A CD    1 
ATOM   1399 C  CE    . LYS A 1 178 ? 126.155 162.213 119.026 1.00 118.21 ? 168 LYS A CE    1 
ATOM   1400 N  NZ    . LYS A 1 178 ? 125.727 161.041 118.205 1.00 109.94 ? 168 LYS A NZ    1 
ATOM   1401 N  N     . LYS A 1 179 ? 122.841 166.300 123.080 1.00 143.38 ? 169 LYS A N     1 
ATOM   1402 C  CA    . LYS A 1 179 ? 121.621 166.773 123.727 1.00 143.73 ? 169 LYS A CA    1 
ATOM   1403 C  C     . LYS A 1 179 ? 120.753 165.610 124.194 1.00 145.73 ? 169 LYS A C     1 
ATOM   1404 O  O     . LYS A 1 179 ? 120.139 165.678 125.265 1.00 143.71 ? 169 LYS A O     1 
ATOM   1405 C  CB    . LYS A 1 179 ? 120.838 167.674 122.772 1.00 139.47 ? 169 LYS A CB    1 
ATOM   1406 C  CG    . LYS A 1 179 ? 119.798 168.549 123.453 1.00 132.87 ? 169 LYS A CG    1 
ATOM   1407 C  CD    . LYS A 1 179 ? 118.896 169.229 122.436 1.00 130.78 ? 169 LYS A CD    1 
ATOM   1408 C  CE    . LYS A 1 179 ? 119.703 169.929 121.357 1.00 127.60 ? 169 LYS A CE    1 
ATOM   1409 N  NZ    . LYS A 1 179 ? 118.830 170.548 120.322 1.00 116.67 ? 169 LYS A NZ    1 
ATOM   1410 N  N     . THR A 1 180 ? 120.686 164.539 123.398 1.00 146.90 ? 170 THR A N     1 
ATOM   1411 C  CA    . THR A 1 180 ? 119.834 163.404 123.743 1.00 145.35 ? 170 THR A CA    1 
ATOM   1412 C  C     . THR A 1 180 ? 120.304 162.722 125.021 1.00 144.20 ? 170 THR A C     1 
ATOM   1413 O  O     . THR A 1 180 ? 119.484 162.283 125.835 1.00 143.25 ? 170 THR A O     1 
ATOM   1414 C  CB    . THR A 1 180 ? 119.802 162.402 122.589 1.00 142.48 ? 170 THR A CB    1 
ATOM   1415 O  OG1   . THR A 1 180 ? 121.117 161.872 122.377 1.00 141.88 ? 170 THR A OG1   1 
ATOM   1416 C  CG2   . THR A 1 180 ? 119.320 163.075 121.311 1.00 137.64 ? 170 THR A CG2   1 
ATOM   1417 N  N     . ASP A 1 181 ? 121.622 162.619 125.208 1.00 144.17 ? 171 ASP A N     1 
ATOM   1418 C  CA    . ASP A 1 181 ? 122.162 161.917 126.368 1.00 143.41 ? 171 ASP A CA    1 
ATOM   1419 C  C     . ASP A 1 181 ? 121.733 162.567 127.677 1.00 142.43 ? 171 ASP A C     1 
ATOM   1420 O  O     . ASP A 1 181 ? 121.633 161.885 128.703 1.00 142.49 ? 171 ASP A O     1 
ATOM   1421 C  CB    . ASP A 1 181 ? 123.685 161.854 126.276 1.00 142.35 ? 171 ASP A CB    1 
ATOM   1422 C  CG    . ASP A 1 181 ? 124.162 161.217 124.986 1.00 143.03 ? 171 ASP A CG    1 
ATOM   1423 O  OD1   . ASP A 1 181 ? 123.564 160.204 124.565 1.00 142.19 ? 171 ASP A OD1   1 
ATOM   1424 O  OD2   . ASP A 1 181 ? 125.131 161.733 124.390 1.00 142.33 ? 171 ASP A OD2   1 
ATOM   1425 N  N     . TRP A 1 182 ? 121.483 163.878 127.667 1.00 143.67 ? 172 TRP A N     1 
ATOM   1426 C  CA    . TRP A 1 182 ? 120.933 164.525 128.854 1.00 147.01 ? 172 TRP A CA    1 
ATOM   1427 C  C     . TRP A 1 182 ? 119.566 163.956 129.205 1.00 150.82 ? 172 TRP A C     1 
ATOM   1428 O  O     . TRP A 1 182 ? 119.273 163.701 130.379 1.00 152.52 ? 172 TRP A O     1 
ATOM   1429 C  CB    . TRP A 1 182 ? 120.829 166.031 128.639 1.00 145.03 ? 172 TRP A CB    1 
ATOM   1430 C  CG    . TRP A 1 182 ? 122.122 166.762 128.703 1.00 142.52 ? 172 TRP A CG    1 
ATOM   1431 C  CD1   . TRP A 1 182 ? 122.978 167.009 127.671 1.00 141.56 ? 172 TRP A CD1   1 
ATOM   1432 C  CD2   . TRP A 1 182 ? 122.709 167.355 129.863 1.00 143.76 ? 172 TRP A CD2   1 
ATOM   1433 N  NE1   . TRP A 1 182 ? 124.063 167.723 128.117 1.00 140.83 ? 172 TRP A NE1   1 
ATOM   1434 C  CE2   . TRP A 1 182 ? 123.922 167.948 129.461 1.00 143.99 ? 172 TRP A CE2   1 
ATOM   1435 C  CE3   . TRP A 1 182 ? 122.329 167.441 131.206 1.00 144.03 ? 172 TRP A CE3   1 
ATOM   1436 C  CZ2   . TRP A 1 182 ? 124.755 168.620 130.351 1.00 145.34 ? 172 TRP A CZ2   1 
ATOM   1437 C  CZ3   . TRP A 1 182 ? 123.157 168.111 132.089 1.00 141.57 ? 172 TRP A CZ3   1 
ATOM   1438 C  CH2   . TRP A 1 182 ? 124.357 168.690 131.658 1.00 141.80 ? 172 TRP A CH2   1 
ATOM   1439 N  N     . ASP A 1 183 ? 118.713 163.756 128.197 1.00 150.50 ? 173 ASP A N     1 
ATOM   1440 C  CA    . ASP A 1 183 ? 117.393 163.186 128.440 1.00 148.70 ? 173 ASP A CA    1 
ATOM   1441 C  C     . ASP A 1 183 ? 117.501 161.771 128.993 1.00 149.88 ? 173 ASP A C     1 
ATOM   1442 O  O     . ASP A 1 183 ? 116.688 161.356 129.827 1.00 149.55 ? 173 ASP A O     1 
ATOM   1443 C  CB    . ASP A 1 183 ? 116.578 163.191 127.148 1.00 145.67 ? 173 ASP A CB    1 
ATOM   1444 C  CG    . ASP A 1 183 ? 116.194 164.587 126.705 1.00 142.99 ? 173 ASP A CG    1 
ATOM   1445 O  OD1   . ASP A 1 183 ? 116.195 165.505 127.552 1.00 144.03 ? 173 ASP A OD1   1 
ATOM   1446 O  OD2   . ASP A 1 183 ? 115.895 164.767 125.506 1.00 136.55 ? 173 ASP A OD2   1 
ATOM   1447 N  N     . GLU A 1 184 ? 118.500 161.015 128.533 1.00 149.87 ? 174 GLU A N     1 
ATOM   1448 C  CA    . GLU A 1 184 ? 118.648 159.630 128.967 1.00 148.07 ? 174 GLU A CA    1 
ATOM   1449 C  C     . GLU A 1 184 ? 118.957 159.543 130.457 1.00 151.52 ? 174 GLU A C     1 
ATOM   1450 O  O     . GLU A 1 184 ? 118.437 158.664 131.155 1.00 153.87 ? 174 GLU A O     1 
ATOM   1451 C  CB    . GLU A 1 184 ? 119.734 158.947 128.137 1.00 144.87 ? 174 GLU A CB    1 
ATOM   1452 C  CG    . GLU A 1 184 ? 119.412 158.897 126.650 1.00 143.53 ? 174 GLU A CG    1 
ATOM   1453 C  CD    . GLU A 1 184 ? 120.645 158.737 125.785 1.00 140.14 ? 174 GLU A CD    1 
ATOM   1454 O  OE1   . GLU A 1 184 ? 121.751 158.584 126.343 1.00 138.13 ? 174 GLU A OE1   1 
ATOM   1455 O  OE2   . GLU A 1 184 ? 120.507 158.763 124.544 1.00 137.82 ? 174 GLU A OE2   1 
ATOM   1456 N  N     . PHE A 1 185 ? 119.806 160.441 130.964 1.00 150.44 ? 175 PHE A N     1 
ATOM   1457 C  CA    . PHE A 1 185 ? 120.087 160.448 132.396 1.00 152.50 ? 175 PHE A CA    1 
ATOM   1458 C  C     . PHE A 1 185 ? 118.879 160.902 133.203 1.00 153.97 ? 175 PHE A C     1 
ATOM   1459 O  O     . PHE A 1 185 ? 118.704 160.472 134.349 1.00 153.53 ? 175 PHE A O     1 
ATOM   1460 C  CB    . PHE A 1 185 ? 121.289 161.338 132.702 1.00 151.49 ? 175 PHE A CB    1 
ATOM   1461 C  CG    . PHE A 1 185 ? 121.627 161.406 134.162 1.00 151.81 ? 175 PHE A CG    1 
ATOM   1462 C  CD1   . PHE A 1 185 ? 122.078 160.283 134.833 1.00 149.93 ? 175 PHE A CD1   1 
ATOM   1463 C  CD2   . PHE A 1 185 ? 121.481 162.588 134.867 1.00 151.21 ? 175 PHE A CD2   1 
ATOM   1464 C  CE1   . PHE A 1 185 ? 122.383 160.338 136.178 1.00 149.56 ? 175 PHE A CE1   1 
ATOM   1465 C  CE2   . PHE A 1 185 ? 121.787 162.650 136.212 1.00 148.72 ? 175 PHE A CE2   1 
ATOM   1466 C  CZ    . PHE A 1 185 ? 122.238 161.524 136.868 1.00 148.30 ? 175 PHE A CZ    1 
ATOM   1467 N  N     . ILE A 1 186 ? 118.046 161.776 132.634 1.00 153.51 ? 176 ILE A N     1 
ATOM   1468 C  CA    . ILE A 1 186 ? 116.806 162.158 133.304 1.00 154.74 ? 176 ILE A CA    1 
ATOM   1469 C  C     . ILE A 1 186 ? 115.898 160.945 133.458 1.00 155.25 ? 176 ILE A C     1 
ATOM   1470 O  O     . ILE A 1 186 ? 115.288 160.734 134.513 1.00 157.38 ? 176 ILE A O     1 
ATOM   1471 C  CB    . ILE A 1 186 ? 116.111 163.298 132.534 1.00 154.13 ? 176 ILE A CB    1 
ATOM   1472 C  CG1   . ILE A 1 186 ? 117.001 164.543 132.488 1.00 152.82 ? 176 ILE A CG1   1 
ATOM   1473 C  CG2   . ILE A 1 186 ? 114.771 163.635 133.170 1.00 150.94 ? 176 ILE A CG2   1 
ATOM   1474 C  CD1   . ILE A 1 186 ? 117.699 164.864 133.798 1.00 152.47 ? 176 ILE A CD1   1 
ATOM   1475 N  N     . SER A 1 187 ? 115.801 160.125 132.410 1.00 154.64 ? 177 SER A N     1 
ATOM   1476 C  CA    . SER A 1 187 ? 115.003 158.907 132.449 1.00 156.36 ? 177 SER A CA    1 
ATOM   1477 C  C     . SER A 1 187 ? 115.661 157.786 133.246 1.00 157.96 ? 177 SER A C     1 
ATOM   1478 O  O     . SER A 1 187 ? 115.009 156.766 133.495 1.00 157.25 ? 177 SER A O     1 
ATOM   1479 C  CB    . SER A 1 187 ? 114.724 158.427 131.024 1.00 150.60 ? 177 SER A CB    1 
ATOM   1480 O  OG    . SER A 1 187 ? 114.289 157.079 131.013 1.00 149.65 ? 177 SER A OG    1 
ATOM   1481 N  N     . TYR A 1 188 ? 116.925 157.945 133.646 1.00 157.87 ? 178 TYR A N     1 
ATOM   1482 C  CA    . TYR A 1 188 ? 117.631 156.864 134.327 1.00 156.47 ? 178 TYR A CA    1 
ATOM   1483 C  C     . TYR A 1 188 ? 117.025 156.569 135.695 1.00 155.80 ? 178 TYR A C     1 
ATOM   1484 O  O     . TYR A 1 188 ? 116.964 155.409 136.117 1.00 152.99 ? 178 TYR A O     1 
ATOM   1485 C  CB    . TYR A 1 188 ? 119.116 157.209 134.462 1.00 154.17 ? 178 TYR A CB    1 
ATOM   1486 C  CG    . TYR A 1 188 ? 119.976 156.046 134.904 1.00 150.95 ? 178 TYR A CG    1 
ATOM   1487 C  CD1   . TYR A 1 188 ? 119.995 154.857 134.184 1.00 149.45 ? 178 TYR A CD1   1 
ATOM   1488 C  CD2   . TYR A 1 188 ? 120.765 156.133 136.045 1.00 146.39 ? 178 TYR A CD2   1 
ATOM   1489 C  CE1   . TYR A 1 188 ? 120.777 153.790 134.586 1.00 146.77 ? 178 TYR A CE1   1 
ATOM   1490 C  CE2   . TYR A 1 188 ? 121.549 155.071 136.454 1.00 144.55 ? 178 TYR A CE2   1 
ATOM   1491 C  CZ    . TYR A 1 188 ? 121.551 153.902 135.721 1.00 146.23 ? 178 TYR A CZ    1 
ATOM   1492 O  OH    . TYR A 1 188 ? 122.329 152.840 136.122 1.00 144.40 ? 178 TYR A OH    1 
ATOM   1493 N  N     . ILE A 1 189 ? 116.579 157.603 136.406 1.00 158.23 ? 179 ILE A N     1 
ATOM   1494 C  CA    . ILE A 1 189 ? 116.106 157.436 137.776 1.00 158.34 ? 179 ILE A CA    1 
ATOM   1495 C  C     . ILE A 1 189 ? 114.582 157.437 137.813 1.00 159.74 ? 179 ILE A C     1 
ATOM   1496 O  O     . ILE A 1 189 ? 113.975 156.757 138.648 1.00 160.91 ? 179 ILE A O     1 
ATOM   1497 C  CB    . ILE A 1 189 ? 116.681 158.530 138.695 1.00 155.09 ? 179 ILE A CB    1 
ATOM   1498 C  CG1   . ILE A 1 189 ? 118.196 158.634 138.519 1.00 150.29 ? 179 ILE A CG1   1 
ATOM   1499 C  CG2   . ILE A 1 189 ? 116.348 158.236 140.153 1.00 150.66 ? 179 ILE A CG2   1 
ATOM   1500 C  CD1   . ILE A 1 189 ? 118.943 157.378 138.896 1.00 142.75 ? 179 ILE A CD1   1 
ATOM   1501 N  N     . GLU A 1 190 ? 113.954 158.197 136.912 1.00 159.63 ? 180 GLU A N     1 
ATOM   1502 C  CA    . GLU A 1 190 ? 112.497 158.304 136.926 1.00 160.26 ? 180 GLU A CA    1 
ATOM   1503 C  C     . GLU A 1 190 ? 111.836 156.959 136.653 1.00 161.96 ? 180 GLU A C     1 
ATOM   1504 O  O     . GLU A 1 190 ? 110.827 156.616 137.280 1.00 161.89 ? 180 GLU A O     1 
ATOM   1505 C  CB    . GLU A 1 190 ? 112.029 159.345 135.909 1.00 159.82 ? 180 GLU A CB    1 
ATOM   1506 C  CG    . GLU A 1 190 ? 112.260 160.782 136.342 1.00 160.09 ? 180 GLU A CG    1 
ATOM   1507 C  CD    . GLU A 1 190 ? 111.280 161.238 137.409 1.00 161.54 ? 180 GLU A CD    1 
ATOM   1508 O  OE1   . GLU A 1 190 ? 110.321 160.491 137.703 1.00 162.65 ? 180 GLU A OE1   1 
ATOM   1509 O  OE2   . GLU A 1 190 ? 111.468 162.345 137.958 1.00 158.63 ? 180 GLU A OE2   1 
ATOM   1510 N  N     . ASN A 1 191 ? 112.385 156.185 135.715 1.00 162.29 ? 181 ASN A N     1 
ATOM   1511 C  CA    . ASN A 1 191 ? 111.852 154.856 135.445 1.00 163.70 ? 181 ASN A CA    1 
ATOM   1512 C  C     . ASN A 1 191 ? 112.107 153.886 136.594 1.00 163.93 ? 181 ASN A C     1 
ATOM   1513 O  O     . ASN A 1 191 ? 111.466 152.831 136.653 1.00 162.56 ? 181 ASN A O     1 
ATOM   1514 C  CB    . ASN A 1 191 ? 112.446 154.311 134.146 1.00 162.44 ? 181 ASN A CB    1 
ATOM   1515 C  CG    . ASN A 1 191 ? 112.273 155.269 132.980 1.00 160.83 ? 181 ASN A CG    1 
ATOM   1516 O  OD1   . ASN A 1 191 ? 111.538 156.252 133.075 1.00 159.55 ? 181 ASN A OD1   1 
ATOM   1517 N  ND2   . ASN A 1 191 ? 112.951 154.987 131.874 1.00 159.24 ? 181 ASN A ND2   1 
ATOM   1518 N  N     . VAL A 1 192 ? 113.023 154.217 137.500 1.00 164.90 ? 182 VAL A N     1 
ATOM   1519 C  CA    . VAL A 1 192 ? 113.255 153.412 138.694 1.00 162.89 ? 182 VAL A CA    1 
ATOM   1520 C  C     . VAL A 1 192 ? 112.213 153.773 139.745 1.00 162.50 ? 182 VAL A C     1 
ATOM   1521 O  O     . VAL A 1 192 ? 111.825 154.939 139.882 1.00 162.50 ? 182 VAL A O     1 
ATOM   1522 C  CB    . VAL A 1 192 ? 114.691 153.624 139.213 1.00 158.72 ? 182 VAL A CB    1 
ATOM   1523 C  CG1   . VAL A 1 192 ? 114.864 153.045 140.613 1.00 152.58 ? 182 VAL A CG1   1 
ATOM   1524 C  CG2   . VAL A 1 192 ? 115.692 153.001 138.254 1.00 155.48 ? 182 VAL A CG2   1 
ATOM   1525 N  N     . GLU A 1 193 ? 111.748 152.763 140.481 1.00 159.47 ? 183 GLU A N     1 
ATOM   1526 C  CA    . GLU A 1 193 ? 110.687 152.951 141.462 1.00 158.61 ? 183 GLU A CA    1 
ATOM   1527 C  C     . GLU A 1 193 ? 111.072 153.996 142.504 1.00 162.36 ? 183 GLU A C     1 
ATOM   1528 O  O     . GLU A 1 193 ? 112.170 153.958 143.066 1.00 163.12 ? 183 GLU A O     1 
ATOM   1529 C  CB    . GLU A 1 193 ? 110.371 151.618 142.142 1.00 155.55 ? 183 GLU A CB    1 
ATOM   1530 C  CG    . GLU A 1 193 ? 109.461 151.722 143.355 1.00 156.49 ? 183 GLU A CG    1 
ATOM   1531 C  CD    . GLU A 1 193 ? 109.387 150.426 144.138 1.00 152.64 ? 183 GLU A CD    1 
ATOM   1532 O  OE1   . GLU A 1 193 ? 109.713 149.364 143.567 1.00 148.74 ? 183 GLU A OE1   1 
ATOM   1533 O  OE2   . GLU A 1 193 ? 109.008 150.468 145.326 1.00 151.48 ? 183 GLU A OE2   1 
ATOM   1534 N  N     . ASN A 1 194 ? 110.150 154.926 142.761 1.00 163.86 ? 184 ASN A N     1 
ATOM   1535 C  CA    . ASN A 1 194 ? 110.286 155.996 143.746 1.00 163.98 ? 184 ASN A CA    1 
ATOM   1536 C  C     . ASN A 1 194 ? 111.513 156.864 143.487 1.00 163.24 ? 184 ASN A C     1 
ATOM   1537 O  O     . ASN A 1 194 ? 112.476 156.820 144.264 1.00 162.73 ? 184 ASN A O     1 
ATOM   1538 C  CB    . ASN A 1 194 ? 110.346 155.414 145.161 1.00 163.75 ? 184 ASN A CB    1 
ATOM   1539 C  CG    . ASN A 1 194 ? 109.188 154.482 145.460 1.00 160.45 ? 184 ASN A CG    1 
ATOM   1540 O  OD1   . ASN A 1 194 ? 108.196 154.451 144.734 1.00 159.48 ? 184 ASN A OD1   1 
ATOM   1541 N  ND2   . ASN A 1 194 ? 109.312 153.713 146.534 1.00 157.17 ? 184 ASN A ND2   1 
ATOM   1542 N  N     . PRO A 1 195 ? 111.525 157.661 142.422 1.00 162.39 ? 185 PRO A N     1 
ATOM   1543 C  CA    . PRO A 1 195 ? 112.640 158.584 142.200 1.00 161.08 ? 185 PRO A CA    1 
ATOM   1544 C  C     . PRO A 1 195 ? 112.494 159.848 143.035 1.00 157.89 ? 185 PRO A C     1 
ATOM   1545 O  O     . PRO A 1 195 ? 111.409 160.201 143.501 1.00 156.98 ? 185 PRO A O     1 
ATOM   1546 C  CB    . PRO A 1 195 ? 112.541 158.903 140.706 1.00 157.43 ? 185 PRO A CB    1 
ATOM   1547 C  CG    . PRO A 1 195 ? 111.087 158.790 140.418 1.00 157.49 ? 185 PRO A CG    1 
ATOM   1548 C  CD    . PRO A 1 195 ? 110.545 157.711 141.322 1.00 158.59 ? 185 PRO A CD    1 
ATOM   1549 N  N     . ASN A 1 196 ? 113.619 160.533 143.217 1.00 155.37 ? 186 ASN A N     1 
ATOM   1550 C  CA    . ASN A 1 196 ? 113.622 161.815 143.914 1.00 154.00 ? 186 ASN A CA    1 
ATOM   1551 C  C     . ASN A 1 196 ? 113.318 162.912 142.902 1.00 153.38 ? 186 ASN A C     1 
ATOM   1552 O  O     . ASN A 1 196 ? 114.107 163.159 141.985 1.00 152.02 ? 186 ASN A O     1 
ATOM   1553 C  CB    . ASN A 1 196 ? 114.960 162.053 144.608 1.00 151.59 ? 186 ASN A CB    1 
ATOM   1554 C  CG    . ASN A 1 196 ? 114.955 163.301 145.470 1.00 150.03 ? 186 ASN A CG    1 
ATOM   1555 O  OD1   . ASN A 1 196 ? 113.899 163.860 145.767 1.00 148.44 ? 186 ASN A OD1   1 
ATOM   1556 N  ND2   . ASN A 1 196 ? 116.137 163.739 145.886 1.00 148.19 ? 186 ASN A ND2   1 
ATOM   1557 N  N     . ILE A 1 197 ? 112.166 163.565 143.063 1.00 153.24 ? 187 ILE A N     1 
ATOM   1558 C  CA    . ILE A 1 197 ? 111.714 164.540 142.075 1.00 153.61 ? 187 ILE A CA    1 
ATOM   1559 C  C     . ILE A 1 197 ? 112.632 165.755 142.054 1.00 150.97 ? 187 ILE A C     1 
ATOM   1560 O  O     . ILE A 1 197 ? 112.974 166.272 140.984 1.00 150.36 ? 187 ILE A O     1 
ATOM   1561 C  CB    . ILE A 1 197 ? 110.253 164.939 142.351 1.00 151.89 ? 187 ILE A CB    1 
ATOM   1562 C  CG1   . ILE A 1 197 ? 109.419 163.709 142.720 1.00 149.63 ? 187 ILE A CG1   1 
ATOM   1563 C  CG2   . ILE A 1 197 ? 109.659 165.652 141.146 1.00 147.22 ? 187 ILE A CG2   1 
ATOM   1564 C  CD1   . ILE A 1 197 ? 109.414 162.625 141.660 1.00 149.44 ? 187 ILE A CD1   1 
ATOM   1565 N  N     . ASP A 1 198 ? 113.035 166.237 143.231 1.00 148.62 ? 188 ASP A N     1 
ATOM   1566 C  CA    . ASP A 1 198 ? 113.848 167.447 143.298 1.00 147.90 ? 188 ASP A CA    1 
ATOM   1567 C  C     . ASP A 1 198 ? 115.232 167.224 142.699 1.00 150.54 ? 188 ASP A C     1 
ATOM   1568 O  O     . ASP A 1 198 ? 115.767 168.104 142.014 1.00 150.17 ? 188 ASP A O     1 
ATOM   1569 C  CB    . ASP A 1 198 ? 113.951 167.918 144.750 1.00 145.23 ? 188 ASP A CB    1 
ATOM   1570 C  CG    . ASP A 1 198 ? 114.322 169.384 144.870 1.00 140.92 ? 188 ASP A CG    1 
ATOM   1571 O  OD1   . ASP A 1 198 ? 114.905 169.942 143.917 1.00 141.93 ? 188 ASP A OD1   1 
ATOM   1572 O  OD2   . ASP A 1 198 ? 114.027 169.981 145.925 1.00 135.97 ? 188 ASP A OD2   1 
ATOM   1573 N  N     . ASN A 1 199 ? 115.827 166.054 142.945 1.00 152.06 ? 189 ASN A N     1 
ATOM   1574 C  CA    . ASN A 1 199 ? 117.192 165.801 142.491 1.00 150.05 ? 189 ASN A CA    1 
ATOM   1575 C  C     . ASN A 1 199 ? 117.290 165.779 140.969 1.00 151.70 ? 189 ASN A C     1 
ATOM   1576 O  O     . ASN A 1 199 ? 118.230 166.341 140.395 1.00 150.37 ? 189 ASN A O     1 
ATOM   1577 C  CB    . ASN A 1 199 ? 117.700 164.485 143.077 1.00 147.41 ? 189 ASN A CB    1 
ATOM   1578 C  CG    . ASN A 1 199 ? 119.207 164.452 143.212 1.00 146.18 ? 189 ASN A CG    1 
ATOM   1579 O  OD1   . ASN A 1 199 ? 119.862 165.495 143.220 1.00 147.09 ? 189 ASN A OD1   1 
ATOM   1580 N  ND2   . ASN A 1 199 ? 119.767 163.253 143.319 1.00 142.18 ? 189 ASN A ND2   1 
ATOM   1581 N  N     . ILE A 1 200 ? 116.338 165.128 140.298 1.00 151.86 ? 190 ILE A N     1 
ATOM   1582 C  CA    . ILE A 1 200 ? 116.408 165.013 138.844 1.00 150.43 ? 190 ILE A CA    1 
ATOM   1583 C  C     . ILE A 1 200 ? 116.148 166.361 138.181 1.00 151.86 ? 190 ILE A C     1 
ATOM   1584 O  O     . ILE A 1 200 ? 116.765 166.693 137.162 1.00 151.76 ? 190 ILE A O     1 
ATOM   1585 C  CB    . ILE A 1 200 ? 115.436 163.928 138.350 1.00 149.83 ? 190 ILE A CB    1 
ATOM   1586 C  CG1   . ILE A 1 200 ? 115.591 162.670 139.204 1.00 149.75 ? 190 ILE A CG1   1 
ATOM   1587 C  CG2   . ILE A 1 200 ? 115.715 163.590 136.895 1.00 147.29 ? 190 ILE A CG2   1 
ATOM   1588 C  CD1   . ILE A 1 200 ? 114.606 161.578 138.876 1.00 151.63 ? 190 ILE A CD1   1 
ATOM   1589 N  N     . ASN A 1 201 ? 115.232 167.158 138.743 1.00 151.83 ? 191 ASN A N     1 
ATOM   1590 C  CA    . ASN A 1 201 ? 114.991 168.501 138.221 1.00 150.12 ? 191 ASN A CA    1 
ATOM   1591 C  C     . ASN A 1 201 ? 116.256 169.349 138.255 1.00 151.83 ? 191 ASN A C     1 
ATOM   1592 O  O     . ASN A 1 201 ? 116.448 170.222 137.398 1.00 151.63 ? 191 ASN A O     1 
ATOM   1593 C  CB    . ASN A 1 201 ? 113.886 169.187 139.025 1.00 148.01 ? 191 ASN A CB    1 
ATOM   1594 C  CG    . ASN A 1 201 ? 112.521 168.570 138.793 1.00 148.92 ? 191 ASN A CG    1 
ATOM   1595 O  OD1   . ASN A 1 201 ? 112.158 168.243 137.664 1.00 151.30 ? 191 ASN A OD1   1 
ATOM   1596 N  ND2   . ASN A 1 201 ? 111.755 168.409 139.867 1.00 145.05 ? 191 ASN A ND2   1 
ATOM   1597 N  N     . ARG A 1 202 ? 117.123 169.105 139.241 1.00 153.88 ? 192 ARG A N     1 
ATOM   1598 C  CA    . ARG A 1 202 ? 118.371 169.851 139.354 1.00 152.05 ? 192 ARG A CA    1 
ATOM   1599 C  C     . ARG A 1 202 ? 119.251 169.643 138.128 1.00 152.77 ? 192 ARG A C     1 
ATOM   1600 O  O     . ARG A 1 202 ? 119.977 170.553 137.713 1.00 150.65 ? 192 ARG A O     1 
ATOM   1601 C  CB    . ARG A 1 202 ? 119.091 169.433 140.637 1.00 148.79 ? 192 ARG A CB    1 
ATOM   1602 C  CG    . ARG A 1 202 ? 120.557 169.816 140.753 1.00 148.97 ? 192 ARG A CG    1 
ATOM   1603 C  CD    . ARG A 1 202 ? 121.091 169.322 142.088 1.00 148.80 ? 192 ARG A CD    1 
ATOM   1604 N  NE    . ARG A 1 202 ? 122.264 170.051 142.554 1.00 147.55 ? 192 ARG A NE    1 
ATOM   1605 C  CZ    . ARG A 1 202 ? 123.501 169.572 142.543 1.00 144.15 ? 192 ARG A CZ    1 
ATOM   1606 N  NH1   . ARG A 1 202 ? 123.771 168.367 142.069 1.00 142.01 ? 192 ARG A NH1   1 
ATOM   1607 N  NH2   . ARG A 1 202 ? 124.489 170.316 143.031 1.00 141.71 ? 192 ARG A NH2   1 
ATOM   1608 N  N     . TYR A 1 203 ? 119.190 168.455 137.526 1.00 154.44 ? 193 TYR A N     1 
ATOM   1609 C  CA    . TYR A 1 203 ? 119.920 168.196 136.291 1.00 153.56 ? 193 TYR A CA    1 
ATOM   1610 C  C     . TYR A 1 203 ? 119.110 168.539 135.045 1.00 152.95 ? 193 TYR A C     1 
ATOM   1611 O  O     . TYR A 1 203 ? 119.698 168.852 134.005 1.00 151.29 ? 193 TYR A O     1 
ATOM   1612 C  CB    . TYR A 1 203 ? 120.364 166.732 136.234 1.00 153.55 ? 193 TYR A CB    1 
ATOM   1613 C  CG    . TYR A 1 203 ? 120.841 166.181 137.561 1.00 152.18 ? 193 TYR A CG    1 
ATOM   1614 C  CD1   . TYR A 1 203 ? 121.908 166.762 138.234 1.00 147.91 ? 193 TYR A CD1   1 
ATOM   1615 C  CD2   . TYR A 1 203 ? 120.238 165.069 138.132 1.00 151.16 ? 193 TYR A CD2   1 
ATOM   1616 C  CE1   . TYR A 1 203 ? 122.349 166.262 139.443 1.00 145.89 ? 193 TYR A CE1   1 
ATOM   1617 C  CE2   . TYR A 1 203 ? 120.677 164.559 139.338 1.00 149.99 ? 193 TYR A CE2   1 
ATOM   1618 C  CZ    . TYR A 1 203 ? 121.732 165.160 139.989 1.00 147.19 ? 193 TYR A CZ    1 
ATOM   1619 O  OH    . TYR A 1 203 ? 122.171 164.657 141.192 1.00 144.83 ? 193 TYR A OH    1 
ATOM   1620 N  N     . LYS A 1 204 ? 117.776 168.492 135.127 1.00 152.59 ? 194 LYS A N     1 
ATOM   1621 C  CA    . LYS A 1 204 ? 116.950 168.951 134.012 1.00 149.65 ? 194 LYS A CA    1 
ATOM   1622 C  C     . LYS A 1 204 ? 117.193 170.427 133.725 1.00 149.50 ? 194 LYS A C     1 
ATOM   1623 O  O     . LYS A 1 204 ? 117.282 170.840 132.560 1.00 149.20 ? 194 LYS A O     1 
ATOM   1624 C  CB    . LYS A 1 204 ? 115.469 168.719 134.315 1.00 146.13 ? 194 LYS A CB    1 
ATOM   1625 C  CG    . LYS A 1 204 ? 115.087 167.286 134.619 1.00 147.15 ? 194 LYS A CG    1 
ATOM   1626 C  CD    . LYS A 1 204 ? 113.619 167.196 134.996 1.00 147.34 ? 194 LYS A CD    1 
ATOM   1627 C  CE    . LYS A 1 204 ? 113.286 165.864 135.648 1.00 148.30 ? 194 LYS A CE    1 
ATOM   1628 N  NZ    . LYS A 1 204 ? 111.857 165.773 136.055 1.00 144.31 ? 194 LYS A NZ    1 
ATOM   1629 N  N     . LEU A 1 205 ? 117.297 171.236 134.781 1.00 150.17 ? 195 LEU A N     1 
ATOM   1630 C  CA    . LEU A 1 205 ? 117.537 172.664 134.607 1.00 146.77 ? 195 LEU A CA    1 
ATOM   1631 C  C     . LEU A 1 205 ? 118.845 172.917 133.870 1.00 145.66 ? 195 LEU A C     1 
ATOM   1632 O  O     . LEU A 1 205 ? 118.907 173.756 132.965 1.00 142.71 ? 195 LEU A O     1 
ATOM   1633 C  CB    . LEU A 1 205 ? 117.547 173.358 135.969 1.00 142.20 ? 195 LEU A CB    1 
ATOM   1634 C  CG    . LEU A 1 205 ? 117.718 174.876 135.980 1.00 135.95 ? 195 LEU A CG    1 
ATOM   1635 C  CD1   . LEU A 1 205 ? 116.621 175.538 135.163 1.00 133.01 ? 195 LEU A CD1   1 
ATOM   1636 C  CD2   . LEU A 1 205 ? 117.726 175.399 137.406 1.00 132.04 ? 195 LEU A CD2   1 
ATOM   1637 N  N     . LEU A 1 206 ? 119.900 172.186 134.234 1.00 146.95 ? 196 LEU A N     1 
ATOM   1638 C  CA    . LEU A 1 206 ? 121.193 172.379 133.588 1.00 144.37 ? 196 LEU A CA    1 
ATOM   1639 C  C     . LEU A 1 206 ? 121.217 171.782 132.187 1.00 144.17 ? 196 LEU A C     1 
ATOM   1640 O  O     . LEU A 1 206 ? 121.960 172.263 131.324 1.00 144.70 ? 196 LEU A O     1 
ATOM   1641 C  CB    . LEU A 1 206 ? 122.292 171.775 134.455 1.00 145.80 ? 196 LEU A CB    1 
ATOM   1642 C  CG    . LEU A 1 206 ? 122.141 172.174 135.922 1.00 145.95 ? 196 LEU A CG    1 
ATOM   1643 C  CD1   . LEU A 1 206 ? 123.122 171.416 136.793 1.00 145.38 ? 196 LEU A CD1   1 
ATOM   1644 C  CD2   . LEU A 1 206 ? 122.300 173.678 136.094 1.00 140.73 ? 196 LEU A CD2   1 
ATOM   1645 N  N     . ARG A 1 207 ? 120.424 170.737 131.943 1.00 146.25 ? 197 ARG A N     1 
ATOM   1646 C  CA    . ARG A 1 207 ? 120.236 170.259 130.579 1.00 146.88 ? 197 ARG A CA    1 
ATOM   1647 C  C     . ARG A 1 207 ? 119.621 171.349 129.715 1.00 145.42 ? 197 ARG A C     1 
ATOM   1648 O  O     . ARG A 1 207 ? 120.018 171.542 128.559 1.00 142.44 ? 197 ARG A O     1 
ATOM   1649 C  CB    . ARG A 1 207 ? 119.353 169.009 130.579 1.00 146.55 ? 197 ARG A CB    1 
ATOM   1650 C  CG    . ARG A 1 207 ? 118.543 168.814 129.312 1.00 144.76 ? 197 ARG A CG    1 
ATOM   1651 C  CD    . ARG A 1 207 ? 117.316 167.963 129.571 1.00 144.08 ? 197 ARG A CD    1 
ATOM   1652 N  NE    . ARG A 1 207 ? 116.298 168.703 130.306 1.00 145.87 ? 197 ARG A NE    1 
ATOM   1653 C  CZ    . ARG A 1 207 ? 115.099 168.229 130.613 1.00 145.39 ? 197 ARG A CZ    1 
ATOM   1654 N  NH1   . ARG A 1 207 ? 114.727 167.009 130.261 1.00 145.28 ? 197 ARG A NH1   1 
ATOM   1655 N  NH2   . ARG A 1 207 ? 114.248 169.001 131.283 1.00 143.65 ? 197 ARG A NH2   1 
ATOM   1656 N  N     . LYS A 1 208 ? 118.646 172.073 130.265 1.00 146.37 ? 198 LYS A N     1 
ATOM   1657 C  CA    . LYS A 1 208 ? 118.125 173.249 129.576 1.00 145.42 ? 198 LYS A CA    1 
ATOM   1658 C  C     . LYS A 1 208 ? 119.219 174.291 129.380 1.00 143.33 ? 198 LYS A C     1 
ATOM   1659 O  O     . LYS A 1 208 ? 119.325 174.896 128.307 1.00 141.49 ? 198 LYS A O     1 
ATOM   1660 C  CB    . LYS A 1 208 ? 116.947 173.839 130.352 1.00 143.51 ? 198 LYS A CB    1 
ATOM   1661 C  CG    . LYS A 1 208 ? 115.802 172.867 130.579 1.00 141.45 ? 198 LYS A CG    1 
ATOM   1662 C  CD    . LYS A 1 208 ? 114.776 173.439 131.544 1.00 138.02 ? 198 LYS A CD    1 
ATOM   1663 C  CE    . LYS A 1 208 ? 113.749 172.392 131.945 1.00 137.10 ? 198 LYS A CE    1 
ATOM   1664 N  NZ    . LYS A 1 208 ? 112.789 172.917 132.956 1.00 131.85 ? 198 LYS A NZ    1 
ATOM   1665 N  N     . CYS A 1 209 ? 120.044 174.513 130.407 1.00 144.19 ? 199 CYS A N     1 
ATOM   1666 C  CA    . CYS A 1 209 ? 121.161 175.444 130.271 1.00 145.50 ? 199 CYS A CA    1 
ATOM   1667 C  C     . CYS A 1 209 ? 122.193 174.945 129.268 1.00 145.08 ? 199 CYS A C     1 
ATOM   1668 O  O     . CYS A 1 209 ? 122.890 175.751 128.641 1.00 141.75 ? 199 CYS A O     1 
ATOM   1669 C  CB    . CYS A 1 209 ? 121.819 175.687 131.630 1.00 144.05 ? 199 CYS A CB    1 
ATOM   1670 S  SG    . CYS A 1 209 ? 120.699 176.283 132.918 1.00 144.87 ? 199 CYS A SG    1 
ATOM   1671 N  N     . PHE A 1 210 ? 122.303 173.625 129.105 1.00 146.53 ? 200 PHE A N     1 
ATOM   1672 C  CA    . PHE A 1 210 ? 123.279 173.061 128.177 1.00 143.46 ? 200 PHE A CA    1 
ATOM   1673 C  C     . PHE A 1 210 ? 123.022 173.522 126.748 1.00 140.42 ? 200 PHE A C     1 
ATOM   1674 O  O     . PHE A 1 210 ? 123.965 173.745 125.979 1.00 136.02 ? 200 PHE A O     1 
ATOM   1675 C  CB    . PHE A 1 210 ? 123.246 171.536 128.260 1.00 140.18 ? 200 PHE A CB    1 
ATOM   1676 C  CG    . PHE A 1 210 ? 124.276 170.861 127.407 1.00 139.66 ? 200 PHE A CG    1 
ATOM   1677 C  CD1   . PHE A 1 210 ? 125.592 170.785 127.820 1.00 140.25 ? 200 PHE A CD1   1 
ATOM   1678 C  CD2   . PHE A 1 210 ? 123.926 170.301 126.190 1.00 139.75 ? 200 PHE A CD2   1 
ATOM   1679 C  CE1   . PHE A 1 210 ? 126.539 170.166 127.036 1.00 141.09 ? 200 PHE A CE1   1 
ATOM   1680 C  CE2   . PHE A 1 210 ? 124.868 169.681 125.402 1.00 137.77 ? 200 PHE A CE2   1 
ATOM   1681 C  CZ    . PHE A 1 210 ? 126.176 169.613 125.826 1.00 137.88 ? 200 PHE A CZ    1 
ATOM   1682 N  N     . CYS A 1 211 ? 121.750 173.666 126.373 1.00 142.94 ? 201 CYS A N     1 
ATOM   1683 C  CA    . CYS A 1 211 ? 121.417 174.025 125.000 1.00 141.17 ? 201 CYS A CA    1 
ATOM   1684 C  C     . CYS A 1 211 ? 121.675 175.500 124.715 1.00 138.02 ? 201 CYS A C     1 
ATOM   1685 O  O     . CYS A 1 211 ? 121.966 175.864 123.571 1.00 133.97 ? 201 CYS A O     1 
ATOM   1686 C  CB    . CYS A 1 211 ? 119.955 173.681 124.716 1.00 139.01 ? 201 CYS A CB    1 
ATOM   1687 S  SG    . CYS A 1 211 ? 119.592 171.915 124.778 1.00 135.89 ? 201 CYS A SG    1 
ATOM   1688 N  N     . GLU A 1 212 ? 121.569 176.357 125.733 1.00 137.92 ? 202 GLU A N     1 
ATOM   1689 C  CA    . GLU A 1 212 ? 121.611 177.798 125.499 1.00 138.87 ? 202 GLU A CA    1 
ATOM   1690 C  C     . GLU A 1 212 ? 122.959 178.238 124.941 1.00 137.18 ? 202 GLU A C     1 
ATOM   1691 O  O     . GLU A 1 212 ? 123.027 178.901 123.900 1.00 132.42 ? 202 GLU A O     1 
ATOM   1692 C  CB    . GLU A 1 212 ? 121.305 178.542 126.799 1.00 139.07 ? 202 GLU A CB    1 
ATOM   1693 C  CG    . GLU A 1 212 ? 119.996 178.145 127.452 1.00 139.60 ? 202 GLU A CG    1 
ATOM   1694 C  CD    . GLU A 1 212 ? 120.018 178.342 128.953 1.00 139.40 ? 202 GLU A CD    1 
ATOM   1695 O  OE1   . GLU A 1 212 ? 121.045 178.824 129.474 1.00 140.88 ? 202 GLU A OE1   1 
ATOM   1696 O  OE2   . GLU A 1 212 ? 119.013 178.005 129.615 1.00 134.19 ? 202 GLU A OE2   1 
ATOM   1697 N  N     . ASN A 1 213 ? 124.044 177.872 125.616 1.00 137.65 ? 203 ASN A N     1 
ATOM   1698 C  CA    . ASN A 1 213 ? 125.381 178.367 125.305 1.00 137.00 ? 203 ASN A CA    1 
ATOM   1699 C  C     . ASN A 1 213 ? 126.384 177.221 125.300 1.00 134.24 ? 203 ASN A C     1 
ATOM   1700 O  O     . ASN A 1 213 ? 127.436 177.279 125.940 1.00 129.88 ? 203 ASN A O     1 
ATOM   1701 C  CB    . ASN A 1 213 ? 125.794 179.453 126.294 1.00 135.18 ? 203 ASN A CB    1 
ATOM   1702 C  CG    . ASN A 1 213 ? 126.911 180.327 125.767 1.00 134.15 ? 203 ASN A CG    1 
ATOM   1703 O  OD1   . ASN A 1 213 ? 127.529 180.017 124.748 1.00 134.07 ? 203 ASN A OD1   1 
ATOM   1704 N  ND2   . ASN A 1 213 ? 127.182 181.425 126.463 1.00 128.88 ? 203 ASN A ND2   1 
ATOM   1705 N  N     . GLU A 1 214 ? 126.049 176.147 124.577 1.00 133.41 ? 204 GLU A N     1 
ATOM   1706 C  CA    . GLU A 1 214 ? 126.894 174.955 124.565 1.00 128.68 ? 204 GLU A CA    1 
ATOM   1707 C  C     . GLU A 1 214 ? 128.327 175.271 124.161 1.00 125.92 ? 204 GLU A C     1 
ATOM   1708 O  O     . GLU A 1 214 ? 129.261 174.629 124.654 1.00 120.87 ? 204 GLU A O     1 
ATOM   1709 C  CB    . GLU A 1 214 ? 126.311 173.904 123.621 1.00 127.17 ? 204 GLU A CB    1 
ATOM   1710 C  CG    . GLU A 1 214 ? 126.777 172.491 123.920 1.00 128.62 ? 204 GLU A CG    1 
ATOM   1711 C  CD    . GLU A 1 214 ? 126.374 171.506 122.843 1.00 129.08 ? 204 GLU A CD    1 
ATOM   1712 O  OE1   . GLU A 1 214 ? 125.563 171.878 121.970 1.00 131.31 ? 204 GLU A OE1   1 
ATOM   1713 O  OE2   . GLU A 1 214 ? 126.873 170.362 122.866 1.00 124.61 ? 204 GLU A OE2   1 
ATOM   1714 N  N     . ASN A 1 215 ? 128.523 176.252 123.276 1.00 125.75 ? 205 ASN A N     1 
ATOM   1715 C  CA    . ASN A 1 215 ? 129.878 176.613 122.871 1.00 124.31 ? 205 ASN A CA    1 
ATOM   1716 C  C     . ASN A 1 215 ? 130.704 177.059 124.067 1.00 121.26 ? 205 ASN A C     1 
ATOM   1717 O  O     . ASN A 1 215 ? 131.854 176.633 124.228 1.00 115.09 ? 205 ASN A O     1 
ATOM   1718 C  CB    . ASN A 1 215 ? 129.840 177.709 121.804 1.00 124.20 ? 205 ASN A CB    1 
ATOM   1719 C  CG    . ASN A 1 215 ? 131.228 178.198 121.419 1.00 122.55 ? 205 ASN A CG    1 
ATOM   1720 O  OD1   . ASN A 1 215 ? 131.850 177.669 120.498 1.00 116.84 ? 205 ASN A OD1   1 
ATOM   1721 N  ND2   . ASN A 1 215 ? 131.714 179.218 122.117 1.00 118.82 ? 205 ASN A ND2   1 
ATOM   1722 N  N     . MET A 1 216 ? 130.131 177.902 124.931 1.00 122.69 ? 206 MET A N     1 
ATOM   1723 C  CA    . MET A 1 216 ? 130.858 178.321 126.124 1.00 122.22 ? 206 MET A CA    1 
ATOM   1724 C  C     . MET A 1 216 ? 131.130 177.134 127.040 1.00 119.05 ? 206 MET A C     1 
ATOM   1725 O  O     . MET A 1 216 ? 132.221 177.021 127.606 1.00 111.16 ? 206 MET A O     1 
ATOM   1726 C  CB    . MET A 1 216 ? 130.096 179.430 126.861 1.00 125.70 ? 206 MET A CB    1 
ATOM   1727 C  CG    . MET A 1 216 ? 129.198 178.976 128.010 1.00 126.91 ? 206 MET A CG    1 
ATOM   1728 S  SD    . MET A 1 216 ? 128.326 180.323 128.837 1.00 139.27 ? 206 MET A SD    1 
ATOM   1729 C  CE    . MET A 1 216 ? 129.694 181.240 129.543 1.00 115.46 ? 206 MET A CE    1 
ATOM   1730 N  N     . ILE A 1 217 ? 130.170 176.214 127.164 1.00 121.79 ? 207 ILE A N     1 
ATOM   1731 C  CA    . ILE A 1 217 ? 130.335 175.090 128.080 1.00 118.37 ? 207 ILE A CA    1 
ATOM   1732 C  C     . ILE A 1 217 ? 131.446 174.164 127.603 1.00 111.43 ? 207 ILE A C     1 
ATOM   1733 O  O     . ILE A 1 217 ? 132.365 173.829 128.360 1.00 105.87 ? 207 ILE A O     1 
ATOM   1734 C  CB    . ILE A 1 217 ? 129.004 174.336 128.243 1.00 121.79 ? 207 ILE A CB    1 
ATOM   1735 C  CG1   . ILE A 1 217 ? 127.957 175.251 128.879 1.00 125.45 ? 207 ILE A CG1   1 
ATOM   1736 C  CG2   . ILE A 1 217 ? 129.204 173.074 129.069 1.00 119.97 ? 207 ILE A CG2   1 
ATOM   1737 C  CD1   . ILE A 1 217 ? 126.559 174.692 128.847 1.00 132.79 ? 207 ILE A CD1   1 
ATOM   1738 N  N     . LYS A 1 218 ? 131.384 173.743 126.339 1.00 113.25 ? 208 LYS A N     1 
ATOM   1739 C  CA    . LYS A 1 218 ? 132.407 172.844 125.815 1.00 108.40 ? 208 LYS A CA    1 
ATOM   1740 C  C     . LYS A 1 218 ? 133.767 173.524 125.771 1.00 101.18 ? 208 LYS A C     1 
ATOM   1741 O  O     . LYS A 1 218 ? 134.783 172.918 126.134 1.00 95.69  ? 208 LYS A O     1 
ATOM   1742 C  CB    . LYS A 1 218 ? 132.007 172.343 124.427 1.00 109.71 ? 208 LYS A CB    1 
ATOM   1743 C  CG    . LYS A 1 218 ? 130.674 171.610 124.394 1.00 112.42 ? 208 LYS A CG    1 
ATOM   1744 C  CD    . LYS A 1 218 ? 130.201 171.362 122.966 1.00 117.26 ? 208 LYS A CD    1 
ATOM   1745 C  CE    . LYS A 1 218 ? 129.968 172.667 122.221 1.00 115.54 ? 208 LYS A CE    1 
ATOM   1746 N  NZ    . LYS A 1 218 ? 129.142 172.479 120.999 1.00 107.49 ? 208 LYS A NZ    1 
ATOM   1747 N  N     . ASN A 1 219 ? 133.806 174.788 125.339 1.00 103.95 ? 209 ASN A N     1 
ATOM   1748 C  CA    . ASN A 1 219 ? 135.075 175.502 125.264 1.00 99.72  ? 209 ASN A CA    1 
ATOM   1749 C  C     . ASN A 1 219 ? 135.695 175.673 126.643 1.00 94.48  ? 209 ASN A C     1 
ATOM   1750 O  O     . ASN A 1 219 ? 136.905 175.502 126.805 1.00 88.69  ? 209 ASN A O     1 
ATOM   1751 C  CB    . ASN A 1 219 ? 134.880 176.859 124.590 1.00 99.60  ? 209 ASN A CB    1 
ATOM   1752 C  CG    . ASN A 1 219 ? 136.174 177.424 124.036 1.00 91.85  ? 209 ASN A CG    1 
ATOM   1753 O  OD1   . ASN A 1 219 ? 137.134 176.693 123.800 1.00 89.25  ? 209 ASN A OD1   1 
ATOM   1754 N  ND2   . ASN A 1 219 ? 136.204 178.734 123.829 1.00 91.84  ? 209 ASN A ND2   1 
ATOM   1755 N  N     . LYS A 1 220 ? 134.884 175.991 127.655 1.00 98.31  ? 210 LYS A N     1 
ATOM   1756 C  CA    . LYS A 1 220 ? 135.417 176.176 129.000 1.00 97.09  ? 210 LYS A CA    1 
ATOM   1757 C  C     . LYS A 1 220 ? 135.847 174.851 129.613 1.00 92.50  ? 210 LYS A C     1 
ATOM   1758 O  O     . LYS A 1 220 ? 136.869 174.788 130.304 1.00 86.84  ? 210 LYS A O     1 
ATOM   1759 C  CB    . LYS A 1 220 ? 134.380 176.867 129.884 1.00 100.70 ? 210 LYS A CB    1 
ATOM   1760 C  CG    . LYS A 1 220 ? 134.878 177.203 131.280 1.00 99.88  ? 210 LYS A CG    1 
ATOM   1761 C  CD    . LYS A 1 220 ? 133.757 177.758 132.143 1.00 107.93 ? 210 LYS A CD    1 
ATOM   1762 C  CE    . LYS A 1 220 ? 134.185 177.873 133.596 1.00 104.56 ? 210 LYS A CE    1 
ATOM   1763 N  NZ    . LYS A 1 220 ? 133.117 178.471 134.443 1.00 105.60 ? 210 LYS A NZ    1 
ATOM   1764 N  N     . LEU A 1 221 ? 135.087 173.780 129.373 1.00 91.58  ? 211 LEU A N     1 
ATOM   1765 C  CA    . LEU A 1 221 ? 135.489 172.475 129.883 1.00 86.85  ? 211 LEU A CA    1 
ATOM   1766 C  C     . LEU A 1 221 ? 136.818 172.041 129.277 1.00 87.14  ? 211 LEU A C     1 
ATOM   1767 O  O     . LEU A 1 221 ? 137.708 171.559 129.988 1.00 88.06  ? 211 LEU A O     1 
ATOM   1768 C  CB    . LEU A 1 221 ? 134.400 171.442 129.598 1.00 81.58  ? 211 LEU A CB    1 
ATOM   1769 C  CG    . LEU A 1 221 ? 134.408 170.208 130.500 1.00 77.43  ? 211 LEU A CG    1 
ATOM   1770 C  CD1   . LEU A 1 221 ? 134.263 170.621 131.949 1.00 85.07  ? 211 LEU A CD1   1 
ATOM   1771 C  CD2   . LEU A 1 221 ? 133.311 169.236 130.111 1.00 77.14  ? 211 LEU A CD2   1 
ATOM   1772 N  N     . GLU A 1 222 ? 136.988 172.236 127.967 1.00 85.29  ? 212 GLU A N     1 
ATOM   1773 C  CA    . GLU A 1 222 ? 138.245 171.847 127.341 1.00 77.73  ? 212 GLU A CA    1 
ATOM   1774 C  C     . GLU A 1 222 ? 139.381 172.793 127.717 1.00 78.42  ? 212 GLU A C     1 
ATOM   1775 O  O     . GLU A 1 222 ? 140.533 172.361 127.815 1.00 76.83  ? 212 GLU A O     1 
ATOM   1776 C  CB    . GLU A 1 222 ? 138.069 171.765 125.826 1.00 77.37  ? 212 GLU A CB    1 
ATOM   1777 C  CG    . GLU A 1 222 ? 137.165 170.611 125.403 1.00 80.49  ? 212 GLU A CG    1 
ATOM   1778 C  CD    . GLU A 1 222 ? 137.130 170.388 123.903 1.00 82.40  ? 212 GLU A CD    1 
ATOM   1779 O  OE1   . GLU A 1 222 ? 137.832 171.116 123.171 1.00 83.57  ? 212 GLU A OE1   1 
ATOM   1780 O  OE2   . GLU A 1 222 ? 136.397 169.480 123.457 1.00 70.44  ? 212 GLU A OE2   1 
ATOM   1781 N  N     . LEU A 1 223 ? 139.084 174.073 127.950 1.00 80.83  ? 213 LEU A N     1 
ATOM   1782 C  CA    . LEU A 1 223 ? 140.109 174.991 128.429 1.00 78.05  ? 213 LEU A CA    1 
ATOM   1783 C  C     . LEU A 1 223 ? 140.585 174.603 129.820 1.00 79.74  ? 213 LEU A C     1 
ATOM   1784 O  O     . LEU A 1 223 ? 141.785 174.652 130.107 1.00 77.72  ? 213 LEU A O     1 
ATOM   1785 C  CB    . LEU A 1 223 ? 139.580 176.424 128.419 1.00 79.42  ? 213 LEU A CB    1 
ATOM   1786 C  CG    . LEU A 1 223 ? 139.612 177.132 127.065 1.00 86.24  ? 213 LEU A CG    1 
ATOM   1787 C  CD1   . LEU A 1 223 ? 138.852 178.446 127.124 1.00 83.19  ? 213 LEU A CD1   1 
ATOM   1788 C  CD2   . LEU A 1 223 ? 141.049 177.354 126.616 1.00 79.67  ? 213 LEU A CD2   1 
ATOM   1789 N  N     . LEU A 1 224 ? 139.660 174.204 130.694 1.00 79.61  ? 214 LEU A N     1 
ATOM   1790 C  CA    . LEU A 1 224 ? 140.046 173.715 132.012 1.00 77.37  ? 214 LEU A CA    1 
ATOM   1791 C  C     . LEU A 1 224 ? 140.843 172.422 131.915 1.00 77.94  ? 214 LEU A C     1 
ATOM   1792 O  O     . LEU A 1 224 ? 141.810 172.230 132.665 1.00 81.06  ? 214 LEU A O     1 
ATOM   1793 C  CB    . LEU A 1 224 ? 138.805 173.509 132.876 1.00 78.08  ? 214 LEU A CB    1 
ATOM   1794 C  CG    . LEU A 1 224 ? 138.099 174.783 133.332 1.00 84.89  ? 214 LEU A CG    1 
ATOM   1795 C  CD1   . LEU A 1 224 ? 136.815 174.435 134.058 1.00 88.74  ? 214 LEU A CD1   1 
ATOM   1796 C  CD2   . LEU A 1 224 ? 139.010 175.616 134.216 1.00 80.00  ? 214 LEU A CD2   1 
ATOM   1797 N  N     . SER A 1 225 ? 140.454 171.529 131.004 1.00 74.74  ? 215 SER A N     1 
ATOM   1798 C  CA    . SER A 1 225 ? 141.199 170.289 130.815 1.00 72.77  ? 215 SER A CA    1 
ATOM   1799 C  C     . SER A 1 225 ? 142.626 170.567 130.356 1.00 69.00  ? 215 SER A C     1 
ATOM   1800 O  O     . SER A 1 225 ? 143.577 169.956 130.853 1.00 65.68  ? 215 SER A O     1 
ATOM   1801 C  CB    . SER A 1 225 ? 140.467 169.395 129.817 1.00 75.80  ? 215 SER A CB    1 
ATOM   1802 O  OG    . SER A 1 225 ? 139.098 169.272 130.159 1.00 76.19  ? 215 SER A OG    1 
ATOM   1803 N  N     . ILE A 1 226 ? 142.796 171.492 129.408 1.00 70.56  ? 216 ILE A N     1 
ATOM   1804 C  CA    . ILE A 1 226 ? 144.138 171.898 128.997 1.00 63.96  ? 216 ILE A CA    1 
ATOM   1805 C  C     . ILE A 1 226 ? 144.871 172.556 130.155 1.00 62.06  ? 216 ILE A C     1 
ATOM   1806 O  O     . ILE A 1 226 ? 146.091 172.415 130.292 1.00 60.06  ? 216 ILE A O     1 
ATOM   1807 C  CB    . ILE A 1 226 ? 144.067 172.831 127.770 1.00 61.38  ? 216 ILE A CB    1 
ATOM   1808 C  CG1   . ILE A 1 226 ? 143.455 172.104 126.575 1.00 60.84  ? 216 ILE A CG1   1 
ATOM   1809 C  CG2   . ILE A 1 226 ? 145.444 173.359 127.405 1.00 52.94  ? 216 ILE A CG2   1 
ATOM   1810 C  CD1   . ILE A 1 226 ? 143.459 172.918 125.307 1.00 57.63  ? 216 ILE A CD1   1 
ATOM   1811 N  N     . GLU A 1 227 ? 144.145 173.291 131.000 1.00 69.11  ? 217 GLU A N     1 
ATOM   1812 C  CA    . GLU A 1 227 ? 144.761 173.931 132.155 1.00 71.66  ? 217 GLU A CA    1 
ATOM   1813 C  C     . GLU A 1 227 ? 145.362 172.903 133.102 1.00 70.20  ? 217 GLU A C     1 
ATOM   1814 O  O     . GLU A 1 227 ? 146.480 173.084 133.597 1.00 67.10  ? 217 GLU A O     1 
ATOM   1815 C  CB    . GLU A 1 227 ? 143.730 174.797 132.878 1.00 75.69  ? 217 GLU A CB    1 
ATOM   1816 C  CG    . GLU A 1 227 ? 144.121 175.203 134.292 1.00 85.15  ? 217 GLU A CG    1 
ATOM   1817 C  CD    . GLU A 1 227 ? 145.295 176.164 134.330 1.00 94.75  ? 217 GLU A CD    1 
ATOM   1818 O  OE1   . GLU A 1 227 ? 145.539 176.854 133.316 1.00 94.66  ? 217 GLU A OE1   1 
ATOM   1819 O  OE2   . GLU A 1 227 ? 145.975 176.228 135.378 1.00 96.62  ? 217 GLU A OE2   1 
ATOM   1820 N  N     . GLN A 1 228 ? 144.647 171.810 133.356 1.00 70.44  ? 218 GLN A N     1 
ATOM   1821 C  CA    . GLN A 1 228 ? 145.148 170.774 134.248 1.00 63.91  ? 218 GLN A CA    1 
ATOM   1822 C  C     . GLN A 1 228 ? 146.064 169.777 133.554 1.00 63.24  ? 218 GLN A C     1 
ATOM   1823 O  O     . GLN A 1 228 ? 146.215 168.654 134.046 1.00 63.20  ? 218 GLN A O     1 
ATOM   1824 C  CB    . GLN A 1 228 ? 143.993 170.026 134.907 1.00 61.00  ? 218 GLN A CB    1 
ATOM   1825 C  CG    . GLN A 1 228 ? 143.068 170.896 135.709 1.00 68.87  ? 218 GLN A CG    1 
ATOM   1826 C  CD    . GLN A 1 228 ? 142.093 170.079 136.516 1.00 83.75  ? 218 GLN A CD    1 
ATOM   1827 O  OE1   . GLN A 1 228 ? 141.961 168.874 136.309 1.00 83.99  ? 218 GLN A OE1   1 
ATOM   1828 N  NE2   . GLN A 1 228 ? 141.417 170.723 137.456 1.00 89.51  ? 218 GLN A NE2   1 
ATOM   1829 N  N     . LEU A 1 229 ? 146.674 170.150 132.425 1.00 66.63  ? 219 LEU A N     1 
ATOM   1830 C  CA    . LEU A 1 229 ? 147.590 169.256 131.725 1.00 61.58  ? 219 LEU A CA    1 
ATOM   1831 C  C     . LEU A 1 229 ? 148.897 169.943 131.353 1.00 57.26  ? 219 LEU A C     1 
ATOM   1832 O  O     . LEU A 1 229 ? 149.565 169.516 130.408 1.00 53.99  ? 219 LEU A O     1 
ATOM   1833 C  CB    . LEU A 1 229 ? 146.936 168.664 130.475 1.00 60.17  ? 219 LEU A CB    1 
ATOM   1834 C  CG    . LEU A 1 229 ? 145.966 167.510 130.728 1.00 57.36  ? 219 LEU A CG    1 
ATOM   1835 C  CD1   . LEU A 1 229 ? 145.237 167.127 129.456 1.00 47.99  ? 219 LEU A CD1   1 
ATOM   1836 C  CD2   . LEU A 1 229 ? 146.697 166.315 131.318 1.00 47.60  ? 219 LEU A CD2   1 
ATOM   1837 N  N     . LYS A 1 230 ? 149.270 171.004 132.062 1.00 62.05  ? 220 LYS A N     1 
ATOM   1838 C  CA    . LYS A 1 230 ? 150.600 171.577 131.933 1.00 65.15  ? 220 LYS A CA    1 
ATOM   1839 C  C     . LYS A 1 230 ? 151.365 171.602 133.244 1.00 65.86  ? 220 LYS A C     1 
ATOM   1840 O  O     . LYS A 1 230 ? 152.596 171.701 133.218 1.00 64.01  ? 220 LYS A O     1 
ATOM   1841 C  CB    . LYS A 1 230 ? 150.529 173.001 131.362 1.00 71.45  ? 220 LYS A CB    1 
ATOM   1842 C  CG    . LYS A 1 230 ? 151.831 173.468 130.726 1.00 77.59  ? 220 LYS A CG    1 
ATOM   1843 C  CD    . LYS A 1 230 ? 151.771 174.938 130.338 1.00 82.99  ? 220 LYS A CD    1 
ATOM   1844 C  CE    . LYS A 1 230 ? 153.138 175.446 129.916 1.00 78.63  ? 220 LYS A CE    1 
ATOM   1845 N  NZ    . LYS A 1 230 ? 153.131 176.901 129.628 1.00 80.78  ? 220 LYS A NZ    1 
ATOM   1846 N  N     . ASN A 1 231 ? 150.679 171.511 134.380 1.00 66.65  ? 221 ASN A N     1 
ATOM   1847 C  CA    . ASN A 1 231 ? 151.325 171.229 135.652 1.00 66.20  ? 221 ASN A CA    1 
ATOM   1848 C  C     . ASN A 1 231 ? 151.515 169.738 135.886 1.00 63.96  ? 221 ASN A C     1 
ATOM   1849 O  O     . ASN A 1 231 ? 152.117 169.354 136.894 1.00 61.13  ? 221 ASN A O     1 
ATOM   1850 C  CB    . ASN A 1 231 ? 150.517 171.833 136.804 1.00 67.31  ? 221 ASN A CB    1 
ATOM   1851 C  CG    . ASN A 1 231 ? 150.579 173.349 136.828 1.00 72.93  ? 221 ASN A CG    1 
ATOM   1852 O  OD1   . ASN A 1 231 ? 151.520 173.953 136.313 1.00 69.80  ? 221 ASN A OD1   1 
ATOM   1853 N  ND2   . ASN A 1 231 ? 149.572 173.971 137.429 1.00 85.62  ? 221 ASN A ND2   1 
ATOM   1854 N  N     . PHE A 1 232 ? 151.014 168.898 134.984 1.00 59.23  ? 222 PHE A N     1 
ATOM   1855 C  CA    . PHE A 1 232 ? 151.204 167.459 135.076 1.00 52.39  ? 222 PHE A CA    1 
ATOM   1856 C  C     . PHE A 1 232 ? 152.604 167.090 134.606 1.00 52.33  ? 222 PHE A C     1 
ATOM   1857 O  O     . PHE A 1 232 ? 152.997 167.416 133.483 1.00 48.00  ? 222 PHE A O     1 
ATOM   1858 C  CB    . PHE A 1 232 ? 150.149 166.739 134.238 1.00 47.06  ? 222 PHE A CB    1 
ATOM   1859 C  CG    . PHE A 1 232 ? 150.047 165.272 134.516 1.00 44.67  ? 222 PHE A CG    1 
ATOM   1860 C  CD1   . PHE A 1 232 ? 149.914 164.806 135.805 1.00 42.37  ? 222 PHE A CD1   1 
ATOM   1861 C  CD2   . PHE A 1 232 ? 150.074 164.360 133.481 1.00 40.26  ? 222 PHE A CD2   1 
ATOM   1862 C  CE1   . PHE A 1 232 ? 149.816 163.459 136.057 1.00 40.62  ? 222 PHE A CE1   1 
ATOM   1863 C  CE2   . PHE A 1 232 ? 149.974 163.012 133.729 1.00 36.08  ? 222 PHE A CE2   1 
ATOM   1864 C  CZ    . PHE A 1 232 ? 149.846 162.561 135.017 1.00 38.13  ? 222 PHE A CZ    1 
ATOM   1865 N  N     . GLY A 1 233 ? 153.353 166.408 135.467 1.00 48.99  ? 223 GLY A N     1 
ATOM   1866 C  CA    . GLY A 1 233 ? 154.715 166.027 135.155 1.00 47.39  ? 223 GLY A CA    1 
ATOM   1867 C  C     . GLY A 1 233 ? 154.805 164.660 134.513 1.00 50.86  ? 223 GLY A C     1 
ATOM   1868 O  O     . GLY A 1 233 ? 155.878 164.053 134.463 1.00 51.94  ? 223 GLY A O     1 
ATOM   1869 N  N     . GLY A 1 234 ? 153.676 164.163 134.023 1.00 46.25  ? 224 GLY A N     1 
ATOM   1870 C  CA    . GLY A 1 234 ? 153.636 162.884 133.352 1.00 41.15  ? 224 GLY A CA    1 
ATOM   1871 C  C     . GLY A 1 234 ? 153.550 161.723 134.322 1.00 41.22  ? 224 GLY A C     1 
ATOM   1872 O  O     . GLY A 1 234 ? 153.672 161.863 135.538 1.00 42.72  ? 224 GLY A O     1 
ATOM   1873 N  N     . CYS A 1 235 ? 153.326 160.545 133.756 1.00 39.17  ? 225 CYS A N     1 
ATOM   1874 C  CA    . CYS A 1 235 ? 153.273 159.316 134.527 1.00 33.45  ? 225 CYS A CA    1 
ATOM   1875 C  C     . CYS A 1 235 ? 154.688 158.784 134.691 1.00 41.35  ? 225 CYS A C     1 
ATOM   1876 O  O     . CYS A 1 235 ? 155.430 158.667 133.712 1.00 41.54  ? 225 CYS A O     1 
ATOM   1877 C  CB    . CYS A 1 235 ? 152.384 158.293 133.829 1.00 35.14  ? 225 CYS A CB    1 
ATOM   1878 S  SG    . CYS A 1 235 ? 150.707 158.880 133.511 1.00 44.26  ? 225 CYS A SG    1 
ATOM   1879 N  N     . ILE A 1 236 ? 155.066 158.476 135.929 1.00 42.55  ? 226 ILE A N     1 
ATOM   1880 C  CA    . ILE A 1 236 ? 156.427 158.075 136.258 1.00 41.00  ? 226 ILE A CA    1 
ATOM   1881 C  C     . ILE A 1 236 ? 156.397 156.711 136.928 1.00 40.36  ? 226 ILE A C     1 
ATOM   1882 O  O     . ILE A 1 236 ? 155.671 156.507 137.906 1.00 38.65  ? 226 ILE A O     1 
ATOM   1883 C  CB    . ILE A 1 236 ? 157.116 159.110 137.166 1.00 36.54  ? 226 ILE A CB    1 
ATOM   1884 C  CG1   . ILE A 1 236 ? 157.364 160.405 136.397 1.00 38.35  ? 226 ILE A CG1   1 
ATOM   1885 C  CG2   . ILE A 1 236 ? 158.414 158.555 137.711 1.00 35.32  ? 226 ILE A CG2   1 
ATOM   1886 C  CD1   . ILE A 1 236 ? 157.907 161.519 137.249 1.00 38.26  ? 226 ILE A CD1   1 
ATOM   1887 N  N     . MET A 1 237 ? 157.187 155.782 136.401 1.00 45.17  ? 227 MET A N     1 
ATOM   1888 C  CA    . MET A 1 237 ? 157.430 154.507 137.056 1.00 40.88  ? 227 MET A CA    1 
ATOM   1889 C  C     . MET A 1 237 ? 158.602 154.676 138.015 1.00 45.21  ? 227 MET A C     1 
ATOM   1890 O  O     . MET A 1 237 ? 159.673 155.148 137.620 1.00 46.88  ? 227 MET A O     1 
ATOM   1891 C  CB    . MET A 1 237 ? 157.717 153.419 136.021 1.00 40.40  ? 227 MET A CB    1 
ATOM   1892 C  CG    . MET A 1 237 ? 157.701 152.007 136.562 1.00 38.97  ? 227 MET A CG    1 
ATOM   1893 S  SD    . MET A 1 237 ? 157.696 150.783 135.244 1.00 52.89  ? 227 MET A SD    1 
ATOM   1894 C  CE    . MET A 1 237 ? 155.984 150.840 134.743 1.00 31.21  ? 227 MET A CE    1 
ATOM   1895 N  N     . LYS A 1 238 ? 158.396 154.298 139.273 1.00 44.85  ? 228 LYS A N     1 
ATOM   1896 C  CA    . LYS A 1 238 ? 159.345 154.634 140.325 1.00 38.41  ? 228 LYS A CA    1 
ATOM   1897 C  C     . LYS A 1 238 ? 160.622 153.810 140.182 1.00 39.32  ? 228 LYS A C     1 
ATOM   1898 O  O     . LYS A 1 238 ? 160.799 153.034 139.241 1.00 48.67  ? 228 LYS A O     1 
ATOM   1899 C  CB    . LYS A 1 238 ? 158.712 154.424 141.696 1.00 44.32  ? 228 LYS A CB    1 
ATOM   1900 C  CG    . LYS A 1 238 ? 157.211 154.598 141.724 1.00 42.64  ? 228 LYS A CG    1 
ATOM   1901 C  CD    . LYS A 1 238 ? 156.810 156.030 141.431 1.00 38.21  ? 228 LYS A CD    1 
ATOM   1902 C  CE    . LYS A 1 238 ? 155.328 156.128 141.156 1.00 36.31  ? 228 LYS A CE    1 
ATOM   1903 N  NZ    . LYS A 1 238 ? 154.949 157.509 140.807 1.00 37.10  ? 228 LYS A NZ    1 
ATOM   1904 N  N     . GLN A 1 239 ? 161.532 153.993 141.132 1.00 45.40  ? 229 GLN A N     1 
ATOM   1905 C  CA    . GLN A 1 239 ? 162.802 153.282 141.141 1.00 53.09  ? 229 GLN A CA    1 
ATOM   1906 C  C     . GLN A 1 239 ? 162.765 152.006 141.969 1.00 48.18  ? 229 GLN A C     1 
ATOM   1907 O  O     . GLN A 1 239 ? 163.787 151.324 142.072 1.00 51.54  ? 229 GLN A O     1 
ATOM   1908 C  CB    . GLN A 1 239 ? 163.915 154.199 141.661 1.00 54.53  ? 229 GLN A CB    1 
ATOM   1909 C  CG    . GLN A 1 239 ? 164.111 155.463 140.843 1.00 51.59  ? 229 GLN A CG    1 
ATOM   1910 C  CD    . GLN A 1 239 ? 164.483 155.180 139.401 1.00 60.91  ? 229 GLN A CD    1 
ATOM   1911 O  OE1   . GLN A 1 239 ? 165.035 154.127 139.081 1.00 59.22  ? 229 GLN A OE1   1 
ATOM   1912 N  NE2   . GLN A 1 239 ? 164.178 156.123 138.520 1.00 57.71  ? 229 GLN A NE2   1 
ATOM   1913 N  N     . HIS A 1 240 ? 161.618 151.665 142.553 1.00 42.39  ? 230 HIS A N     1 
ATOM   1914 C  CA    . HIS A 1 240 ? 161.494 150.504 143.422 1.00 45.28  ? 230 HIS A CA    1 
ATOM   1915 C  C     . HIS A 1 240 ? 160.554 149.444 142.854 1.00 46.18  ? 230 HIS A C     1 
ATOM   1916 O  O     . HIS A 1 240 ? 159.974 148.664 143.614 1.00 45.27  ? 230 HIS A O     1 
ATOM   1917 C  CB    . HIS A 1 240 ? 161.023 150.950 144.805 1.00 43.21  ? 230 HIS A CB    1 
ATOM   1918 C  CG    . HIS A 1 240 ? 159.595 151.397 144.840 1.00 47.55  ? 230 HIS A CG    1 
ATOM   1919 N  ND1   . HIS A 1 240 ? 159.215 152.690 144.555 1.00 52.76  ? 230 HIS A ND1   1 
ATOM   1920 C  CD2   . HIS A 1 240 ? 158.456 150.724 145.126 1.00 50.50  ? 230 HIS A CD2   1 
ATOM   1921 C  CE1   . HIS A 1 240 ? 157.902 152.793 144.661 1.00 48.44  ? 230 HIS A CE1   1 
ATOM   1922 N  NE2   . HIS A 1 240 ? 157.418 151.614 145.004 1.00 46.73  ? 230 HIS A NE2   1 
ATOM   1923 N  N     . ILE A 1 241 ? 160.418 149.379 141.530 1.00 43.11  ? 231 ILE A N     1 
ATOM   1924 C  CA    . ILE A 1 241 ? 159.330 148.613 140.929 1.00 44.07  ? 231 ILE A CA    1 
ATOM   1925 C  C     . ILE A 1 241 ? 159.718 147.147 140.746 1.00 44.12  ? 231 ILE A C     1 
ATOM   1926 O  O     . ILE A 1 241 ? 159.074 146.251 141.303 1.00 40.12  ? 231 ILE A O     1 
ATOM   1927 C  CB    . ILE A 1 241 ? 158.893 149.262 139.603 1.00 42.91  ? 231 ILE A CB    1 
ATOM   1928 C  CG1   . ILE A 1 241 ? 158.133 150.554 139.889 1.00 36.54  ? 231 ILE A CG1   1 
ATOM   1929 C  CG2   . ILE A 1 241 ? 158.008 148.322 138.806 1.00 46.41  ? 231 ILE A CG2   1 
ATOM   1930 C  CD1   . ILE A 1 241 ? 157.009 150.383 140.883 1.00 34.92  ? 231 ILE A CD1   1 
ATOM   1931 N  N     . ASN A 1 242 ? 160.769 146.883 139.965 1.00 37.52  ? 232 ASN A N     1 
ATOM   1932 C  CA    . ASN A 1 242 ? 161.204 145.515 139.658 1.00 36.17  ? 232 ASN A CA    1 
ATOM   1933 C  C     . ASN A 1 242 ? 160.081 144.690 139.032 1.00 37.82  ? 232 ASN A C     1 
ATOM   1934 O  O     . ASN A 1 242 ? 159.775 143.583 139.473 1.00 36.30  ? 232 ASN A O     1 
ATOM   1935 C  CB    . ASN A 1 242 ? 161.754 144.809 140.900 1.00 39.02  ? 232 ASN A CB    1 
ATOM   1936 C  CG    . ASN A 1 242 ? 163.090 145.352 141.338 1.00 52.62  ? 232 ASN A CG    1 
ATOM   1937 O  OD1   . ASN A 1 242 ? 163.963 145.623 140.513 1.00 53.20  ? 232 ASN A OD1   1 
ATOM   1938 N  ND2   . ASN A 1 242 ? 163.263 145.510 142.644 1.00 48.26  ? 232 ASN A ND2   1 
ATOM   1939 N  N     . SER A 1 243 ? 159.474 145.233 137.982 1.00 37.01  ? 233 SER A N     1 
ATOM   1940 C  CA    . SER A 1 243 ? 158.370 144.563 137.317 1.00 28.73  ? 233 SER A CA    1 
ATOM   1941 C  C     . SER A 1 243 ? 158.321 144.993 135.861 1.00 29.05  ? 233 SER A C     1 
ATOM   1942 O  O     . SER A 1 243 ? 158.480 146.175 135.553 1.00 40.55  ? 233 SER A O     1 
ATOM   1943 C  CB    . SER A 1 243 ? 157.041 144.879 138.010 1.00 30.50  ? 233 SER A CB    1 
ATOM   1944 O  OG    . SER A 1 243 ? 155.956 144.240 137.366 1.00 41.53  ? 233 SER A OG    1 
ATOM   1945 N  N     . MET A 1 244 ? 158.103 144.029 134.971 1.00 23.71  ? 234 MET A N     1 
ATOM   1946 C  CA    . MET A 1 244 ? 157.855 144.307 133.565 1.00 23.55  ? 234 MET A CA    1 
ATOM   1947 C  C     . MET A 1 244 ? 156.718 143.423 133.082 1.00 26.42  ? 234 MET A C     1 
ATOM   1948 O  O     . MET A 1 244 ? 156.615 142.264 133.485 1.00 33.25  ? 234 MET A O     1 
ATOM   1949 C  CB    . MET A 1 244 ? 159.109 144.082 132.716 1.00 24.75  ? 234 MET A CB    1 
ATOM   1950 C  CG    . MET A 1 244 ? 159.721 142.715 132.859 1.00 24.46  ? 234 MET A CG    1 
ATOM   1951 S  SD    . MET A 1 244 ? 161.300 142.581 132.017 1.00 43.11  ? 234 MET A SD    1 
ATOM   1952 C  CE    . MET A 1 244 ? 160.771 142.298 130.343 1.00 26.80  ? 234 MET A CE    1 
ATOM   1953 N  N     . THR A 1 245 ? 155.855 143.977 132.236 1.00 25.02  ? 235 THR A N     1 
ATOM   1954 C  CA    . THR A 1 245 ? 154.709 143.260 131.695 1.00 22.65  ? 235 THR A CA    1 
ATOM   1955 C  C     . THR A 1 245 ? 154.873 143.103 130.191 1.00 23.89  ? 235 THR A C     1 
ATOM   1956 O  O     . THR A 1 245 ? 155.165 144.076 129.491 1.00 32.27  ? 235 THR A O     1 
ATOM   1957 C  CB    . THR A 1 245 ? 153.396 143.987 132.009 1.00 24.95  ? 235 THR A CB    1 
ATOM   1958 O  OG1   . THR A 1 245 ? 153.193 144.030 133.424 1.00 28.50  ? 235 THR A OG1   1 
ATOM   1959 C  CG2   . THR A 1 245 ? 152.222 143.275 131.372 1.00 22.57  ? 235 THR A CG2   1 
ATOM   1960 N  N     . LEU A 1 246 ? 154.687 141.881 129.701 1.00 22.71  ? 236 LEU A N     1 
ATOM   1961 C  CA    . LEU A 1 246 ? 154.743 141.580 128.280 1.00 22.61  ? 236 LEU A CA    1 
ATOM   1962 C  C     . LEU A 1 246 ? 153.435 140.937 127.846 1.00 28.14  ? 236 LEU A C     1 
ATOM   1963 O  O     . LEU A 1 246 ? 152.904 140.068 128.539 1.00 32.37  ? 236 LEU A O     1 
ATOM   1964 C  CB    . LEU A 1 246 ? 155.908 140.638 127.952 1.00 23.07  ? 236 LEU A CB    1 
ATOM   1965 C  CG    . LEU A 1 246 ? 157.309 140.938 128.488 1.00 22.19  ? 236 LEU A CG    1 
ATOM   1966 C  CD1   . LEU A 1 246 ? 158.309 139.986 127.871 1.00 18.73  ? 236 LEU A CD1   1 
ATOM   1967 C  CD2   . LEU A 1 246 ? 157.707 142.372 128.226 1.00 22.63  ? 236 LEU A CD2   1 
ATOM   1968 N  N     . ILE A 1 247 ? 152.917 141.367 126.700 1.00 25.07  ? 237 ILE A N     1 
ATOM   1969 C  CA    . ILE A 1 247 ? 151.773 140.729 126.057 1.00 26.65  ? 237 ILE A CA    1 
ATOM   1970 C  C     . ILE A 1 247 ? 152.314 139.868 124.929 1.00 28.70  ? 237 ILE A C     1 
ATOM   1971 O  O     . ILE A 1 247 ? 152.907 140.384 123.975 1.00 32.09  ? 237 ILE A O     1 
ATOM   1972 C  CB    . ILE A 1 247 ? 150.757 141.744 125.520 1.00 27.13  ? 237 ILE A CB    1 
ATOM   1973 C  CG1   . ILE A 1 247 ? 150.186 142.616 126.633 1.00 29.86  ? 237 ILE A CG1   1 
ATOM   1974 C  CG2   . ILE A 1 247 ? 149.637 141.024 124.801 1.00 20.87  ? 237 ILE A CG2   1 
ATOM   1975 C  CD1   . ILE A 1 247 ? 149.425 141.862 127.653 1.00 21.00  ? 237 ILE A CD1   1 
ATOM   1976 N  N     . ILE A 1 248 ? 152.111 138.558 125.028 1.00 26.48  ? 238 ILE A N     1 
ATOM   1977 C  CA    . ILE A 1 248 ? 152.554 137.618 124.008 1.00 24.59  ? 238 ILE A CA    1 
ATOM   1978 C  C     . ILE A 1 248 ? 151.364 136.766 123.609 1.00 25.02  ? 238 ILE A C     1 
ATOM   1979 O  O     . ILE A 1 248 ? 150.754 136.110 124.459 1.00 29.06  ? 238 ILE A O     1 
ATOM   1980 C  CB    . ILE A 1 248 ? 153.722 136.749 124.497 1.00 25.24  ? 238 ILE A CB    1 
ATOM   1981 C  CG1   . ILE A 1 248 ? 154.847 137.654 124.994 1.00 25.27  ? 238 ILE A CG1   1 
ATOM   1982 C  CG2   . ILE A 1 248 ? 154.216 135.841 123.385 1.00 20.34  ? 238 ILE A CG2   1 
ATOM   1983 C  CD1   . ILE A 1 248 ? 155.897 136.967 125.765 1.00 23.43  ? 238 ILE A CD1   1 
ATOM   1984 N  N     . GLN A 1 249 ? 151.029 136.780 122.319 1.00 25.41  ? 239 GLN A N     1 
ATOM   1985 C  CA    . GLN A 1 249 ? 149.857 136.050 121.854 1.00 25.01  ? 239 GLN A CA    1 
ATOM   1986 C  C     . GLN A 1 249 ? 150.081 134.546 121.892 1.00 30.64  ? 239 GLN A C     1 
ATOM   1987 O  O     . GLN A 1 249 ? 149.181 133.789 122.274 1.00 33.28  ? 239 GLN A O     1 
ATOM   1988 C  CB    . GLN A 1 249 ? 149.491 136.490 120.441 1.00 25.77  ? 239 GLN A CB    1 
ATOM   1989 C  CG    . GLN A 1 249 ? 148.191 135.899 119.947 1.00 28.01  ? 239 GLN A CG    1 
ATOM   1990 C  CD    . GLN A 1 249 ? 147.819 136.385 118.569 1.00 30.37  ? 239 GLN A CD    1 
ATOM   1991 O  OE1   . GLN A 1 249 ? 148.469 137.264 118.012 1.00 28.29  ? 239 GLN A OE1   1 
ATOM   1992 N  NE2   . GLN A 1 249 ? 146.765 135.811 118.009 1.00 30.12  ? 239 GLN A NE2   1 
ATOM   1993 N  N     . HIS A 1 250 ? 151.265 134.091 121.495 1.00 32.83  ? 240 HIS A N     1 
ATOM   1994 C  CA    . HIS A 1 250 ? 151.546 132.667 121.345 1.00 27.55  ? 240 HIS A CA    1 
ATOM   1995 C  C     . HIS A 1 250 ? 152.712 132.286 122.247 1.00 28.22  ? 240 HIS A C     1 
ATOM   1996 O  O     . HIS A 1 250 ? 153.867 132.289 121.819 1.00 39.72  ? 240 HIS A O     1 
ATOM   1997 C  CB    . HIS A 1 250 ? 151.838 132.322 119.891 1.00 32.09  ? 240 HIS A CB    1 
ATOM   1998 C  CG    . HIS A 1 250 ? 150.696 132.597 118.967 1.00 32.14  ? 240 HIS A CG    1 
ATOM   1999 N  ND1   . HIS A 1 250 ? 150.809 133.420 117.868 1.00 34.86  ? 240 HIS A ND1   1 
ATOM   2000 C  CD2   . HIS A 1 250 ? 149.413 132.167 118.985 1.00 28.75  ? 240 HIS A CD2   1 
ATOM   2001 C  CE1   . HIS A 1 250 ? 149.647 133.482 117.246 1.00 33.22  ? 240 HIS A CE1   1 
ATOM   2002 N  NE2   . HIS A 1 250 ? 148.782 132.731 117.904 1.00 33.66  ? 240 HIS A NE2   1 
ATOM   2003 N  N     . PHE A 1 251 ? 152.401 131.948 123.493 1.00 26.64  ? 241 PHE A N     1 
ATOM   2004 C  CA    . PHE A 1 251 ? 153.340 131.287 124.381 1.00 29.10  ? 241 PHE A CA    1 
ATOM   2005 C  C     . PHE A 1 251 ? 152.638 130.095 125.010 1.00 30.62  ? 241 PHE A C     1 
ATOM   2006 O  O     . PHE A 1 251 ? 151.409 130.033 125.064 1.00 34.09  ? 241 PHE A O     1 
ATOM   2007 C  CB    . PHE A 1 251 ? 153.895 132.237 125.453 1.00 26.17  ? 241 PHE A CB    1 
ATOM   2008 C  CG    . PHE A 1 251 ? 152.946 132.523 126.571 1.00 28.40  ? 241 PHE A CG    1 
ATOM   2009 C  CD1   . PHE A 1 251 ? 151.997 133.517 126.451 1.00 28.07  ? 241 PHE A CD1   1 
ATOM   2010 C  CD2   . PHE A 1 251 ? 153.016 131.812 127.755 1.00 31.06  ? 241 PHE A CD2   1 
ATOM   2011 C  CE1   . PHE A 1 251 ? 151.127 133.784 127.482 1.00 26.53  ? 241 PHE A CE1   1 
ATOM   2012 C  CE2   . PHE A 1 251 ? 152.150 132.077 128.786 1.00 30.36  ? 241 PHE A CE2   1 
ATOM   2013 C  CZ    . PHE A 1 251 ? 151.207 133.064 128.650 1.00 28.27  ? 241 PHE A CZ    1 
ATOM   2014 N  N     . LYS A 1 252 ? 153.429 129.133 125.466 1.00 32.56  ? 242 LYS A N     1 
ATOM   2015 C  CA    . LYS A 1 252 ? 152.906 127.875 125.977 1.00 33.84  ? 242 LYS A CA    1 
ATOM   2016 C  C     . LYS A 1 252 ? 153.306 127.689 127.433 1.00 34.82  ? 242 LYS A C     1 
ATOM   2017 O  O     . LYS A 1 252 ? 154.466 127.902 127.796 1.00 34.88  ? 242 LYS A O     1 
ATOM   2018 C  CB    . LYS A 1 252 ? 153.407 126.702 125.136 1.00 31.19  ? 242 LYS A CB    1 
ATOM   2019 C  CG    . LYS A 1 252 ? 152.642 125.420 125.366 1.00 42.22  ? 242 LYS A CG    1 
ATOM   2020 C  CD    . LYS A 1 252 ? 151.149 125.627 125.192 1.00 46.57  ? 242 LYS A CD    1 
ATOM   2021 C  CE    . LYS A 1 252 ? 150.381 124.377 125.578 1.00 55.64  ? 242 LYS A CE    1 
ATOM   2022 N  NZ    . LYS A 1 252 ? 148.910 124.567 125.456 1.00 62.50  ? 242 LYS A NZ    1 
ATOM   2023 N  N     . ILE A 1 253 ? 152.342 127.303 128.261 1.00 31.74  ? 243 ILE A N     1 
ATOM   2024 C  CA    . ILE A 1 253 ? 152.589 126.907 129.641 1.00 34.55  ? 243 ILE A CA    1 
ATOM   2025 C  C     . ILE A 1 253 ? 152.287 125.423 129.740 1.00 35.20  ? 243 ILE A C     1 
ATOM   2026 O  O     . ILE A 1 253 ? 151.171 124.991 129.427 1.00 48.19  ? 243 ILE A O     1 
ATOM   2027 C  CB    . ILE A 1 253 ? 151.729 127.702 130.632 1.00 37.92  ? 243 ILE A CB    1 
ATOM   2028 C  CG1   . ILE A 1 253 ? 152.203 129.149 130.725 1.00 29.82  ? 243 ILE A CG1   1 
ATOM   2029 C  CG2   . ILE A 1 253 ? 151.765 127.046 131.998 1.00 38.37  ? 243 ILE A CG2   1 
ATOM   2030 C  CD1   . ILE A 1 253 ? 151.335 130.002 131.596 1.00 26.54  ? 243 ILE A CD1   1 
ATOM   2031 N  N     . GLU A 1 254 ? 153.267 124.642 130.177 1.00 30.70  ? 244 GLU A N     1 
ATOM   2032 C  CA    . GLU A 1 254 ? 153.135 123.196 130.192 1.00 36.12  ? 244 GLU A CA    1 
ATOM   2033 C  C     . GLU A 1 254 ? 153.417 122.643 131.581 1.00 39.00  ? 244 GLU A C     1 
ATOM   2034 O  O     . GLU A 1 254 ? 154.257 123.162 132.317 1.00 37.31  ? 244 GLU A O     1 
ATOM   2035 C  CB    . GLU A 1 254 ? 154.078 122.546 129.174 1.00 37.80  ? 244 GLU A CB    1 
ATOM   2036 C  CG    . GLU A 1 254 ? 153.914 123.081 127.771 1.00 43.94  ? 244 GLU A CG    1 
ATOM   2037 C  CD    . GLU A 1 254 ? 154.296 122.072 126.712 1.00 53.39  ? 244 GLU A CD    1 
ATOM   2038 O  OE1   . GLU A 1 254 ? 154.983 121.084 127.049 1.00 54.42  ? 244 GLU A OE1   1 
ATOM   2039 O  OE2   . GLU A 1 254 ? 153.903 122.263 125.542 1.00 49.00  ? 244 GLU A OE2   1 
ATOM   2040 N  N     . GLU A 1 255 ? 152.694 121.584 131.927 1.00 41.96  ? 245 GLU A N     1 
ATOM   2041 C  CA    . GLU A 1 255 ? 152.988 120.816 133.126 1.00 40.42  ? 245 GLU A CA    1 
ATOM   2042 C  C     . GLU A 1 255 ? 154.259 120.011 132.925 1.00 45.59  ? 245 GLU A C     1 
ATOM   2043 O  O     . GLU A 1 255 ? 154.495 119.460 131.848 1.00 45.83  ? 245 GLU A O     1 
ATOM   2044 C  CB    . GLU A 1 255 ? 151.838 119.867 133.451 1.00 38.42  ? 245 GLU A CB    1 
ATOM   2045 C  CG    . GLU A 1 255 ? 150.647 120.519 134.086 1.00 43.71  ? 245 GLU A CG    1 
ATOM   2046 C  CD    . GLU A 1 255 ? 149.515 119.547 134.289 1.00 53.86  ? 245 GLU A CD    1 
ATOM   2047 O  OE1   . GLU A 1 255 ? 149.325 118.672 133.423 1.00 51.81  ? 245 GLU A OE1   1 
ATOM   2048 O  OE2   . GLU A 1 255 ? 148.812 119.654 135.312 1.00 56.44  ? 245 GLU A OE2   1 
ATOM   2049 N  N     . LYS A 1 256 ? 155.076 119.936 133.970 1.00 47.91  ? 246 LYS A N     1 
ATOM   2050 C  CA    . LYS A 1 256 ? 156.265 119.108 133.897 1.00 49.93  ? 246 LYS A CA    1 
ATOM   2051 C  C     . LYS A 1 256 ? 155.900 117.633 133.913 1.00 60.25  ? 246 LYS A C     1 
ATOM   2052 O  O     . LYS A 1 256 ? 154.773 117.237 134.222 1.00 63.83  ? 246 LYS A O     1 
ATOM   2053 C  CB    . LYS A 1 256 ? 157.211 119.378 135.058 1.00 45.46  ? 246 LYS A CB    1 
ATOM   2054 C  CG    . LYS A 1 256 ? 157.895 120.700 135.039 1.00 43.08  ? 246 LYS A CG    1 
ATOM   2055 C  CD    . LYS A 1 256 ? 158.751 120.794 136.268 1.00 47.67  ? 246 LYS A CD    1 
ATOM   2056 C  CE    . LYS A 1 256 ? 159.921 119.828 136.162 1.00 48.13  ? 246 LYS A CE    1 
ATOM   2057 N  NZ    . LYS A 1 256 ? 160.883 120.219 135.096 1.00 46.29  ? 246 LYS A NZ    1 
ATOM   2058 N  N     . GLU A 1 257 ? 156.889 116.814 133.587 1.00 62.90  ? 247 GLU A N     1 
ATOM   2059 C  CA    . GLU A 1 257 ? 156.749 115.370 133.637 1.00 66.10  ? 247 GLU A CA    1 
ATOM   2060 C  C     . GLU A 1 257 ? 157.275 114.891 134.983 1.00 64.49  ? 247 GLU A C     1 
ATOM   2061 O  O     . GLU A 1 257 ? 158.427 115.167 135.335 1.00 62.19  ? 247 GLU A O     1 
ATOM   2062 C  CB    . GLU A 1 257 ? 157.502 114.715 132.479 1.00 65.12  ? 247 GLU A CB    1 
ATOM   2063 C  CG    . GLU A 1 257 ? 157.295 115.398 131.124 1.00 71.32  ? 247 GLU A CG    1 
ATOM   2064 C  CD    . GLU A 1 257 ? 158.159 116.640 130.935 1.00 76.10  ? 247 GLU A CD    1 
ATOM   2065 O  OE1   . GLU A 1 257 ? 159.181 116.771 131.640 1.00 77.51  ? 247 GLU A OE1   1 
ATOM   2066 O  OE2   . GLU A 1 257 ? 157.809 117.490 130.090 1.00 68.37  ? 247 GLU A OE2   1 
ATOM   2067 N  N     . ASN A 1 258 ? 156.424 114.195 135.738 1.00 64.91  ? 248 ASN A N     1 
ATOM   2068 C  CA    . ASN A 1 258 ? 156.770 113.681 137.062 1.00 62.00  ? 248 ASN A CA    1 
ATOM   2069 C  C     . ASN A 1 258 ? 157.202 114.819 137.989 1.00 60.04  ? 248 ASN A C     1 
ATOM   2070 O  O     . ASN A 1 258 ? 158.347 114.896 138.438 1.00 62.71  ? 248 ASN A O     1 
ATOM   2071 C  CB    . ASN A 1 258 ? 157.852 112.602 136.962 1.00 61.23  ? 248 ASN A CB    1 
ATOM   2072 C  CG    . ASN A 1 258 ? 157.440 111.449 136.073 1.00 58.42  ? 248 ASN A CG    1 
ATOM   2073 O  OD1   . ASN A 1 258 ? 156.295 111.372 135.632 1.00 56.42  ? 248 ASN A OD1   1 
ATOM   2074 N  ND2   . ASN A 1 258 ? 158.375 110.551 135.796 1.00 55.73  ? 248 ASN A ND2   1 
ATOM   2075 N  N     . SER A 1 259 ? 156.256 115.716 138.256 1.00 57.87  ? 249 SER A N     1 
ATOM   2076 C  CA    . SER A 1 259 ? 156.496 116.900 139.070 1.00 48.29  ? 249 SER A CA    1 
ATOM   2077 C  C     . SER A 1 259 ? 155.155 117.532 139.410 1.00 45.59  ? 249 SER A C     1 
ATOM   2078 O  O     . SER A 1 259 ? 154.105 117.105 138.926 1.00 50.95  ? 249 SER A O     1 
ATOM   2079 C  CB    . SER A 1 259 ? 157.395 117.905 138.352 1.00 45.08  ? 249 SER A CB    1 
ATOM   2080 O  OG    . SER A 1 259 ? 157.572 119.065 139.135 1.00 48.58  ? 249 SER A OG    1 
ATOM   2081 N  N     . LEU A 1 260 ? 155.206 118.553 140.263 1.00 40.47  ? 250 LEU A N     1 
ATOM   2082 C  CA    . LEU A 1 260 ? 154.042 119.369 140.564 1.00 42.10  ? 250 LEU A CA    1 
ATOM   2083 C  C     . LEU A 1 260 ? 154.113 120.758 139.951 1.00 42.71  ? 250 LEU A C     1 
ATOM   2084 O  O     . LEU A 1 260 ? 153.112 121.480 139.985 1.00 43.39  ? 250 LEU A O     1 
ATOM   2085 C  CB    . LEU A 1 260 ? 153.855 119.511 142.082 1.00 44.08  ? 250 LEU A CB    1 
ATOM   2086 C  CG    . LEU A 1 260 ? 153.523 118.268 142.903 1.00 44.16  ? 250 LEU A CG    1 
ATOM   2087 C  CD1   . LEU A 1 260 ? 154.184 118.348 144.261 1.00 47.23  ? 250 LEU A CD1   1 
ATOM   2088 C  CD2   . LEU A 1 260 ? 152.021 118.118 143.049 1.00 42.39  ? 250 LEU A CD2   1 
ATOM   2089 N  N     . GLY A 1 261 ? 155.255 121.147 139.393 1.00 39.98  ? 251 GLY A N     1 
ATOM   2090 C  CA    . GLY A 1 261 ? 155.446 122.473 138.851 1.00 37.99  ? 251 GLY A CA    1 
ATOM   2091 C  C     . GLY A 1 261 ? 155.034 122.582 137.401 1.00 36.97  ? 251 GLY A C     1 
ATOM   2092 O  O     . GLY A 1 261 ? 154.319 121.735 136.861 1.00 38.70  ? 251 GLY A O     1 
ATOM   2093 N  N     . PHE A 1 262 ? 155.494 123.657 136.765 1.00 35.54  ? 252 PHE A N     1 
ATOM   2094 C  CA    . PHE A 1 262 ? 155.172 123.949 135.378 1.00 30.89  ? 252 PHE A CA    1 
ATOM   2095 C  C     . PHE A 1 262 ? 156.424 124.427 134.663 1.00 34.82  ? 252 PHE A C     1 
ATOM   2096 O  O     . PHE A 1 262 ? 157.406 124.825 135.290 1.00 39.22  ? 252 PHE A O     1 
ATOM   2097 C  CB    . PHE A 1 262 ? 154.087 125.021 135.249 1.00 28.05  ? 252 PHE A CB    1 
ATOM   2098 C  CG    . PHE A 1 262 ? 152.810 124.692 135.963 1.00 30.07  ? 252 PHE A CG    1 
ATOM   2099 C  CD1   . PHE A 1 262 ? 152.645 125.007 137.296 1.00 34.15  ? 252 PHE A CD1   1 
ATOM   2100 C  CD2   . PHE A 1 262 ? 151.766 124.095 135.292 1.00 29.13  ? 252 PHE A CD2   1 
ATOM   2101 C  CE1   . PHE A 1 262 ? 151.475 124.715 137.943 1.00 26.34  ? 252 PHE A CE1   1 
ATOM   2102 C  CE2   . PHE A 1 262 ? 150.600 123.807 135.938 1.00 30.45  ? 252 PHE A CE2   1 
ATOM   2103 C  CZ    . PHE A 1 262 ? 150.454 124.121 137.262 1.00 26.40  ? 252 PHE A CZ    1 
ATOM   2104 N  N     . ILE A 1 263 ? 156.377 124.388 133.336 1.00 33.33  ? 253 ILE A N     1 
ATOM   2105 C  CA    . ILE A 1 263 ? 157.432 124.934 132.491 1.00 32.28  ? 253 ILE A CA    1 
ATOM   2106 C  C     . ILE A 1 263 ? 156.812 125.988 131.587 1.00 32.70  ? 253 ILE A C     1 
ATOM   2107 O  O     . ILE A 1 263 ? 155.777 125.742 130.959 1.00 32.47  ? 253 ILE A O     1 
ATOM   2108 C  CB    . ILE A 1 263 ? 158.133 123.840 131.666 1.00 29.54  ? 253 ILE A CB    1 
ATOM   2109 C  CG1   . ILE A 1 263 ? 159.084 123.045 132.553 1.00 34.10  ? 253 ILE A CG1   1 
ATOM   2110 C  CG2   . ILE A 1 263 ? 158.910 124.449 130.520 1.00 29.36  ? 253 ILE A CG2   1 
ATOM   2111 C  CD1   . ILE A 1 263 ? 159.763 121.908 131.847 1.00 40.79  ? 253 ILE A CD1   1 
ATOM   2112 N  N     . LEU A 1 264 ? 157.432 127.161 131.537 1.00 30.90  ? 254 LEU A N     1 
ATOM   2113 C  CA    . LEU A 1 264 ? 156.963 128.265 130.714 1.00 25.77  ? 254 LEU A CA    1 
ATOM   2114 C  C     . LEU A 1 264 ? 157.833 128.359 129.468 1.00 28.53  ? 254 LEU A C     1 
ATOM   2115 O  O     . LEU A 1 264 ? 159.029 128.650 129.563 1.00 29.69  ? 254 LEU A O     1 
ATOM   2116 C  CB    . LEU A 1 264 ? 157.000 129.574 131.502 1.00 23.75  ? 254 LEU A CB    1 
ATOM   2117 C  CG    . LEU A 1 264 ? 157.023 130.888 130.725 1.00 22.27  ? 254 LEU A CG    1 
ATOM   2118 C  CD1   . LEU A 1 264 ? 155.653 131.186 130.175 1.00 30.10  ? 254 LEU A CD1   1 
ATOM   2119 C  CD2   . LEU A 1 264 ? 157.490 132.017 131.611 1.00 20.38  ? 254 LEU A CD2   1 
ATOM   2120 N  N     . ASN A 1 265 ? 157.235 128.107 128.306 1.00 30.73  ? 255 ASN A N     1 
ATOM   2121 C  CA    . ASN A 1 265 ? 157.926 128.241 127.028 1.00 26.33  ? 255 ASN A CA    1 
ATOM   2122 C  C     . ASN A 1 265 ? 157.707 129.654 126.510 1.00 30.32  ? 255 ASN A C     1 
ATOM   2123 O  O     . ASN A 1 265 ? 156.602 130.008 126.094 1.00 36.30  ? 255 ASN A O     1 
ATOM   2124 C  CB    . ASN A 1 265 ? 157.431 127.203 126.028 1.00 28.92  ? 255 ASN A CB    1 
ATOM   2125 C  CG    . ASN A 1 265 ? 157.659 125.790 126.500 1.00 30.80  ? 255 ASN A CG    1 
ATOM   2126 O  OD1   . ASN A 1 265 ? 156.873 125.243 127.267 1.00 31.88  ? 255 ASN A OD1   1 
ATOM   2127 N  ND2   . ASN A 1 265 ? 158.750 125.192 126.049 1.00 28.23  ? 255 ASN A ND2   1 
ATOM   2128 N  N     . LEU A 1 266 ? 158.758 130.453 126.530 1.00 32.69  ? 256 LEU A N     1 
ATOM   2129 C  CA    . LEU A 1 266 ? 158.682 131.869 126.241 1.00 30.92  ? 256 LEU A CA    1 
ATOM   2130 C  C     . LEU A 1 266 ? 159.374 132.165 124.924 1.00 35.93  ? 256 LEU A C     1 
ATOM   2131 O  O     . LEU A 1 266 ? 160.567 131.870 124.788 1.00 42.80  ? 256 LEU A O     1 
ATOM   2132 C  CB    . LEU A 1 266 ? 159.346 132.666 127.368 1.00 26.16  ? 256 LEU A CB    1 
ATOM   2133 C  CG    . LEU A 1 266 ? 159.300 134.188 127.310 1.00 30.56  ? 256 LEU A CG    1 
ATOM   2134 C  CD1   . LEU A 1 266 ? 157.871 134.628 127.396 1.00 30.33  ? 256 LEU A CD1   1 
ATOM   2135 C  CD2   . LEU A 1 266 ? 160.105 134.804 128.430 1.00 31.05  ? 256 LEU A CD2   1 
ATOM   2136 N  N     . PRO A 1 267 ? 158.684 132.732 123.936 1.00 38.57  ? 257 PRO A N     1 
ATOM   2137 C  CA    . PRO A 1 267 ? 159.376 133.133 122.704 1.00 36.50  ? 257 PRO A CA    1 
ATOM   2138 C  C     . PRO A 1 267 ? 160.431 134.185 122.990 1.00 36.00  ? 257 PRO A C     1 
ATOM   2139 O  O     . PRO A 1 267 ? 160.106 135.316 123.357 1.00 34.23  ? 257 PRO A O     1 
ATOM   2140 C  CB    . PRO A 1 267 ? 158.245 133.684 121.828 1.00 36.47  ? 257 PRO A CB    1 
ATOM   2141 C  CG    . PRO A 1 267 ? 157.002 133.106 122.398 1.00 34.68  ? 257 PRO A CG    1 
ATOM   2142 C  CD    . PRO A 1 267 ? 157.238 132.989 123.864 1.00 37.01  ? 257 PRO A CD    1 
ATOM   2143 N  N     . LEU A 1 268 ? 161.699 133.823 122.819 1.00 38.26  ? 258 LEU A N     1 
ATOM   2144 C  CA    . LEU A 1 268 ? 162.813 134.651 123.271 1.00 40.56  ? 258 LEU A CA    1 
ATOM   2145 C  C     . LEU A 1 268 ? 163.957 134.513 122.276 1.00 43.39  ? 258 LEU A C     1 
ATOM   2146 O  O     . LEU A 1 268 ? 164.587 133.455 122.198 1.00 47.29  ? 258 LEU A O     1 
ATOM   2147 C  CB    . LEU A 1 268 ? 163.245 134.239 124.679 1.00 40.80  ? 258 LEU A CB    1 
ATOM   2148 C  CG    . LEU A 1 268 ? 164.512 134.840 125.280 1.00 38.48  ? 258 LEU A CG    1 
ATOM   2149 C  CD1   . LEU A 1 268 ? 164.435 136.334 125.232 1.00 42.43  ? 258 LEU A CD1   1 
ATOM   2150 C  CD2   . LEU A 1 268 ? 164.683 134.372 126.710 1.00 32.73  ? 258 LEU A CD2   1 
ATOM   2151 N  N     . ASN A 1 269 ? 164.224 135.586 121.528 1.00 44.30  ? 259 ASN A N     1 
ATOM   2152 C  CA    . ASN A 1 269 ? 165.260 135.615 120.491 1.00 45.98  ? 259 ASN A CA    1 
ATOM   2153 C  C     . ASN A 1 269 ? 165.003 134.563 119.413 1.00 45.35  ? 259 ASN A C     1 
ATOM   2154 O  O     . ASN A 1 269 ? 165.891 133.799 119.032 1.00 49.91  ? 259 ASN A O     1 
ATOM   2155 C  CB    . ASN A 1 269 ? 166.656 135.451 121.094 1.00 50.54  ? 259 ASN A CB    1 
ATOM   2156 C  CG    . ASN A 1 269 ? 167.743 136.005 120.199 1.00 51.02  ? 259 ASN A CG    1 
ATOM   2157 O  OD1   . ASN A 1 269 ? 167.467 136.532 119.124 1.00 54.34  ? 259 ASN A OD1   1 
ATOM   2158 N  ND2   . ASN A 1 269 ? 168.989 135.884 120.636 1.00 49.79  ? 259 ASN A ND2   1 
ATOM   2159 N  N     . LYS A 1 270 ? 163.766 134.533 118.923 1.00 41.30  ? 260 LYS A N     1 
ATOM   2160 C  CA    . LYS A 1 270 ? 163.312 133.661 117.843 1.00 41.90  ? 260 LYS A CA    1 
ATOM   2161 C  C     . LYS A 1 270 ? 163.403 132.181 118.192 1.00 44.25  ? 260 LYS A C     1 
ATOM   2162 O  O     . LYS A 1 270 ? 163.234 131.331 117.311 1.00 43.07  ? 260 LYS A O     1 
ATOM   2163 C  CB    . LYS A 1 270 ? 164.079 133.937 116.546 1.00 43.17  ? 260 LYS A CB    1 
ATOM   2164 C  CG    . LYS A 1 270 ? 163.990 135.374 116.080 1.00 45.89  ? 260 LYS A CG    1 
ATOM   2165 C  CD    . LYS A 1 270 ? 164.813 135.595 114.831 1.00 52.89  ? 260 LYS A CD    1 
ATOM   2166 C  CE    . LYS A 1 270 ? 165.215 137.053 114.693 1.00 66.71  ? 260 LYS A CE    1 
ATOM   2167 N  NZ    . LYS A 1 270 ? 166.187 137.250 113.584 1.00 71.07  ? 260 LYS A NZ    1 
ATOM   2168 N  N     . LYS A 1 271 ? 163.664 131.848 119.452 1.00 47.32  ? 261 LYS A N     1 
ATOM   2169 C  CA    . LYS A 1 271 ? 163.682 130.473 119.920 1.00 43.99  ? 261 LYS A CA    1 
ATOM   2170 C  C     . LYS A 1 271 ? 162.830 130.373 121.174 1.00 37.90  ? 261 LYS A C     1 
ATOM   2171 O  O     . LYS A 1 271 ? 162.583 131.364 121.861 1.00 39.36  ? 261 LYS A O     1 
ATOM   2172 C  CB    . LYS A 1 271 ? 165.106 129.985 120.224 1.00 47.85  ? 261 LYS A CB    1 
ATOM   2173 C  CG    . LYS A 1 271 ? 166.140 130.338 119.169 1.00 50.21  ? 261 LYS A CG    1 
ATOM   2174 C  CD    . LYS A 1 271 ? 165.958 129.511 117.909 1.00 52.69  ? 261 LYS A CD    1 
ATOM   2175 C  CE    . LYS A 1 271 ? 166.884 129.994 116.806 1.00 52.60  ? 261 LYS A CE    1 
ATOM   2176 N  NZ    . LYS A 1 271 ? 166.656 129.262 115.532 1.00 53.33  ? 261 LYS A NZ    1 
ATOM   2177 N  N     . GLN A 1 272 ? 162.378 129.161 121.471 1.00 38.34  ? 262 GLN A N     1 
ATOM   2178 C  CA    . GLN A 1 272 ? 161.573 128.913 122.660 1.00 37.11  ? 262 GLN A CA    1 
ATOM   2179 C  C     . GLN A 1 272 ? 162.506 128.636 123.831 1.00 37.17  ? 262 GLN A C     1 
ATOM   2180 O  O     . GLN A 1 272 ? 163.207 127.620 123.851 1.00 39.49  ? 262 GLN A O     1 
ATOM   2181 C  CB    . GLN A 1 272 ? 160.610 127.754 122.432 1.00 30.61  ? 262 GLN A CB    1 
ATOM   2182 C  CG    . GLN A 1 272 ? 159.698 127.961 121.248 1.00 38.79  ? 262 GLN A CG    1 
ATOM   2183 C  CD    . GLN A 1 272 ? 158.663 129.034 121.497 1.00 41.25  ? 262 GLN A CD    1 
ATOM   2184 O  OE1   . GLN A 1 272 ? 158.051 129.085 122.560 1.00 42.84  ? 262 GLN A OE1   1 
ATOM   2185 N  NE2   . GLN A 1 272 ? 158.464 129.904 120.517 1.00 35.97  ? 262 GLN A NE2   1 
ATOM   2186 N  N     . TYR A 1 273 ? 162.518 129.545 124.799 1.00 37.24  ? 263 TYR A N     1 
ATOM   2187 C  CA    . TYR A 1 273 ? 163.274 129.378 126.029 1.00 34.42  ? 263 TYR A CA    1 
ATOM   2188 C  C     . TYR A 1 273 ? 162.353 128.810 127.093 1.00 36.92  ? 263 TYR A C     1 
ATOM   2189 O  O     . TYR A 1 273 ? 161.232 129.293 127.267 1.00 40.52  ? 263 TYR A O     1 
ATOM   2190 C  CB    . TYR A 1 273 ? 163.863 130.706 126.499 1.00 29.74  ? 263 TYR A CB    1 
ATOM   2191 C  CG    . TYR A 1 273 ? 164.973 130.533 127.500 1.00 40.23  ? 263 TYR A CG    1 
ATOM   2192 C  CD1   . TYR A 1 273 ? 166.285 130.374 127.085 1.00 34.22  ? 263 TYR A CD1   1 
ATOM   2193 C  CD2   . TYR A 1 273 ? 164.709 130.507 128.861 1.00 41.04  ? 263 TYR A CD2   1 
ATOM   2194 C  CE1   . TYR A 1 273 ? 167.301 130.207 127.991 1.00 38.83  ? 263 TYR A CE1   1 
ATOM   2195 C  CE2   . TYR A 1 273 ? 165.720 130.338 129.777 1.00 46.09  ? 263 TYR A CE2   1 
ATOM   2196 C  CZ    . TYR A 1 273 ? 167.016 130.189 129.336 1.00 51.51  ? 263 TYR A CZ    1 
ATOM   2197 O  OH    . TYR A 1 273 ? 168.035 130.023 130.244 1.00 55.53  ? 263 TYR A OH    1 
ATOM   2198 N  N     . GLN A 1 274 ? 162.819 127.786 127.798 1.00 34.40  ? 264 GLN A N     1 
ATOM   2199 C  CA    . GLN A 1 274 ? 162.018 127.110 128.807 1.00 30.63  ? 264 GLN A CA    1 
ATOM   2200 C  C     . GLN A 1 274 ? 162.399 127.628 130.185 1.00 31.30  ? 264 GLN A C     1 
ATOM   2201 O  O     . GLN A 1 274 ? 163.560 127.532 130.590 1.00 35.36  ? 264 GLN A O     1 
ATOM   2202 C  CB    . GLN A 1 274 ? 162.208 125.599 128.730 1.00 29.31  ? 264 GLN A CB    1 
ATOM   2203 C  CG    . GLN A 1 274 ? 161.850 125.011 127.391 1.00 35.61  ? 264 GLN A CG    1 
ATOM   2204 C  CD    . GLN A 1 274 ? 162.256 123.564 127.283 1.00 51.46  ? 264 GLN A CD    1 
ATOM   2205 O  OE1   . GLN A 1 274 ? 162.811 122.994 128.221 1.00 52.65  ? 264 GLN A OE1   1 
ATOM   2206 N  NE2   . GLN A 1 274 ? 161.986 122.957 126.136 1.00 57.24  ? 264 GLN A NE2   1 
ATOM   2207 N  N     . ILE A 1 275 ? 161.420 128.171 130.898 1.00 28.72  ? 265 ILE A N     1 
ATOM   2208 C  CA    . ILE A 1 275 ? 161.602 128.680 132.250 1.00 24.06  ? 265 ILE A CA    1 
ATOM   2209 C  C     . ILE A 1 275 ? 160.877 127.738 133.196 1.00 29.04  ? 265 ILE A C     1 
ATOM   2210 O  O     . ILE A 1 275 ? 159.661 127.549 133.083 1.00 29.72  ? 265 ILE A O     1 
ATOM   2211 C  CB    . ILE A 1 275 ? 161.082 130.117 132.388 1.00 21.73  ? 265 ILE A CB    1 
ATOM   2212 C  CG1   . ILE A 1 275 ? 161.891 131.059 131.498 1.00 25.20  ? 265 ILE A CG1   1 
ATOM   2213 C  CG2   . ILE A 1 275 ? 161.129 130.560 133.824 1.00 23.18  ? 265 ILE A CG2   1 
ATOM   2214 C  CD1   . ILE A 1 275 ? 161.326 132.449 131.401 1.00 23.73  ? 265 ILE A CD1   1 
ATOM   2215 N  N     . GLU A 1 276 ? 161.620 127.139 134.120 1.00 31.04  ? 266 GLU A N     1 
ATOM   2216 C  CA    . GLU A 1 276 ? 161.024 126.230 135.084 1.00 29.77  ? 266 GLU A CA    1 
ATOM   2217 C  C     . GLU A 1 276 ? 160.392 127.012 136.224 1.00 32.74  ? 266 GLU A C     1 
ATOM   2218 O  O     . GLU A 1 276 ? 160.980 127.958 136.749 1.00 32.44  ? 266 GLU A O     1 
ATOM   2219 C  CB    . GLU A 1 276 ? 162.065 125.259 135.632 1.00 30.24  ? 266 GLU A CB    1 
ATOM   2220 C  CG    . GLU A 1 276 ? 161.446 124.021 136.252 1.00 39.17  ? 266 GLU A CG    1 
ATOM   2221 C  CD    . GLU A 1 276 ? 162.472 123.089 136.850 1.00 47.05  ? 266 GLU A CD    1 
ATOM   2222 O  OE1   . GLU A 1 276 ? 163.655 123.481 136.929 1.00 45.56  ? 266 GLU A OE1   1 
ATOM   2223 O  OE2   . GLU A 1 276 ? 162.097 121.964 137.240 1.00 49.99  ? 266 GLU A OE2   1 
ATOM   2224 N  N     . LEU A 1 277 ? 159.184 126.610 136.601 1.00 33.59  ? 267 LEU A N     1 
ATOM   2225 C  CA    . LEU A 1 277 ? 158.421 127.266 137.650 1.00 28.85  ? 267 LEU A CA    1 
ATOM   2226 C  C     . LEU A 1 277 ? 158.085 126.259 138.735 1.00 38.68  ? 267 LEU A C     1 
ATOM   2227 O  O     . LEU A 1 277 ? 157.783 125.100 138.441 1.00 42.92  ? 267 LEU A O     1 
ATOM   2228 C  CB    . LEU A 1 277 ? 157.125 127.864 137.105 1.00 24.79  ? 267 LEU A CB    1 
ATOM   2229 C  CG    . LEU A 1 277 ? 157.174 128.772 135.880 1.00 26.12  ? 267 LEU A CG    1 
ATOM   2230 C  CD1   . LEU A 1 277 ? 155.785 128.866 135.282 1.00 21.70  ? 267 LEU A CD1   1 
ATOM   2231 C  CD2   . LEU A 1 277 ? 157.700 130.145 136.239 1.00 26.13  ? 267 LEU A CD2   1 
ATOM   2232 N  N     . TRP A 1 278 ? 158.135 126.701 139.988 1.00 33.63  ? 268 TRP A N     1 
ATOM   2233 C  CA    . TRP A 1 278 ? 157.637 125.882 141.079 1.00 27.46  ? 268 TRP A CA    1 
ATOM   2234 C  C     . TRP A 1 278 ? 156.128 125.710 140.948 1.00 30.89  ? 268 TRP A C     1 
ATOM   2235 O  O     . TRP A 1 278 ? 155.477 126.310 140.093 1.00 39.21  ? 268 TRP A O     1 
ATOM   2236 C  CB    . TRP A 1 278 ? 157.975 126.513 142.428 1.00 29.39  ? 268 TRP A CB    1 
ATOM   2237 C  CG    . TRP A 1 278 ? 159.432 126.541 142.770 1.00 30.45  ? 268 TRP A CG    1 
ATOM   2238 C  CD1   . TRP A 1 278 ? 160.293 127.579 142.599 1.00 29.22  ? 268 TRP A CD1   1 
ATOM   2239 C  CD2   . TRP A 1 278 ? 160.191 125.486 143.363 1.00 30.42  ? 268 TRP A CD2   1 
ATOM   2240 N  NE1   . TRP A 1 278 ? 161.542 127.237 143.041 1.00 23.48  ? 268 TRP A NE1   1 
ATOM   2241 C  CE2   . TRP A 1 278 ? 161.506 125.953 143.513 1.00 25.73  ? 268 TRP A CE2   1 
ATOM   2242 C  CE3   . TRP A 1 278 ? 159.886 124.187 143.776 1.00 34.47  ? 268 TRP A CE3   1 
ATOM   2243 C  CZ2   . TRP A 1 278 ? 162.515 125.172 144.059 1.00 30.58  ? 268 TRP A CZ2   1 
ATOM   2244 C  CZ3   . TRP A 1 278 ? 160.886 123.414 144.314 1.00 34.89  ? 268 TRP A CZ3   1 
ATOM   2245 C  CH2   . TRP A 1 278 ? 162.184 123.906 144.453 1.00 32.39  ? 268 TRP A CH2   1 
ATOM   2246 N  N     . GLY A 1 279 ? 155.568 124.870 141.805 1.00 27.53  ? 269 GLY A N     1 
ATOM   2247 C  CA    . GLY A 1 279 ? 154.141 124.660 141.844 1.00 26.76  ? 269 GLY A CA    1 
ATOM   2248 C  C     . GLY A 1 279 ? 153.485 125.458 142.953 1.00 26.58  ? 269 GLY A C     1 
ATOM   2249 O  O     . GLY A 1 279 ? 154.126 125.854 143.919 1.00 30.98  ? 269 GLY A O     1 
ATOM   2250 N  N     . ASN A 1 280 ? 152.191 125.704 142.794 1.00 21.82  ? 270 ASN A N     1 
ATOM   2251 C  CA    . ASN A 1 280 ? 151.378 126.338 143.820 1.00 22.91  ? 270 ASN A CA    1 
ATOM   2252 C  C     . ASN A 1 280 ? 150.358 125.346 144.347 1.00 30.92  ? 270 ASN A C     1 
ATOM   2253 O  O     . ASN A 1 280 ? 149.726 124.626 143.572 1.00 38.31  ? 270 ASN A O     1 
ATOM   2254 C  CB    . ASN A 1 280 ? 150.630 127.563 143.290 1.00 19.37  ? 270 ASN A CB    1 
ATOM   2255 C  CG    . ASN A 1 280 ? 151.485 128.796 143.248 1.00 18.07  ? 270 ASN A CG    1 
ATOM   2256 O  OD1   . ASN A 1 280 ? 152.697 128.719 143.076 1.00 26.27  ? 270 ASN A OD1   1 
ATOM   2257 N  ND2   . ASN A 1 280 ? 150.861 129.947 143.419 1.00 12.65  ? 270 ASN A ND2   1 
ATOM   2258 N  N     . ARG A 1 281 ? 150.181 125.322 145.667 1.00 34.23  ? 271 ARG A N     1 
ATOM   2259 C  CA    . ARG A 1 281 ? 148.993 124.682 146.213 1.00 37.03  ? 271 ARG A CA    1 
ATOM   2260 C  C     . ARG A 1 281 ? 147.733 125.439 145.833 1.00 34.09  ? 271 ARG A C     1 
ATOM   2261 O  O     . ARG A 1 281 ? 146.638 125.056 146.254 1.00 39.57  ? 271 ARG A O     1 
ATOM   2262 C  CB    . ARG A 1 281 ? 149.107 124.568 147.733 1.00 36.43  ? 271 ARG A CB    1 
ATOM   2263 C  CG    . ARG A 1 281 ? 150.348 123.825 148.191 1.00 35.16  ? 271 ARG A CG    1 
ATOM   2264 C  CD    . ARG A 1 281 ? 150.799 124.266 149.564 1.00 34.32  ? 271 ARG A CD    1 
ATOM   2265 N  NE    . ARG A 1 281 ? 152.062 123.639 149.927 1.00 41.64  ? 271 ARG A NE    1 
ATOM   2266 C  CZ    . ARG A 1 281 ? 153.255 124.146 149.655 1.00 43.06  ? 271 ARG A CZ    1 
ATOM   2267 N  NH1   . ARG A 1 281 ? 153.388 125.306 149.036 1.00 38.38  ? 271 ARG A NH1   1 
ATOM   2268 N  NH2   . ARG A 1 281 ? 154.342 123.473 150.013 1.00 49.93  ? 271 ARG A NH2   1 
ATOM   2269 N  N     . GLN A 1 282 ? 147.879 126.509 145.054 1.00 29.66  ? 272 GLN A N     1 
ATOM   2270 C  CA    . GLN A 1 282 ? 146.751 127.335 144.657 1.00 30.29  ? 272 GLN A CA    1 
ATOM   2271 C  C     . GLN A 1 282 ? 146.241 126.898 143.288 1.00 34.24  ? 272 GLN A C     1 
ATOM   2272 O  O     . GLN A 1 282 ? 145.034 126.918 143.026 1.00 34.53  ? 272 GLN A O     1 
ATOM   2273 C  CB    . GLN A 1 282 ? 147.203 128.796 144.678 1.00 17.82  ? 272 GLN A CB    1 
ATOM   2274 C  CG    . GLN A 1 282 ? 146.148 129.834 144.472 1.00 17.11  ? 272 GLN A CG    1 
ATOM   2275 C  CD    . GLN A 1 282 ? 146.715 131.228 144.582 1.00 15.21  ? 272 GLN A CD    1 
ATOM   2276 O  OE1   . GLN A 1 282 ? 147.915 131.406 144.742 1.00 13.56  ? 272 GLN A OE1   1 
ATOM   2277 N  NE2   . GLN A 1 282 ? 145.847 132.225 144.540 1.00 25.03  ? 272 GLN A NE2   1 
ATOM   2278 N  N     . VAL A 1 283 ? 147.156 126.485 142.414 1.00 33.84  ? 273 VAL A N     1 
ATOM   2279 C  CA    . VAL A 1 283 ? 146.870 125.702 141.212 1.00 35.93  ? 273 VAL A CA    1 
ATOM   2280 C  C     . VAL A 1 283 ? 147.592 124.373 141.376 1.00 37.07  ? 273 VAL A C     1 
ATOM   2281 O  O     . VAL A 1 283 ? 148.773 124.246 141.035 1.00 38.72  ? 273 VAL A O     1 
ATOM   2282 C  CB    . VAL A 1 283 ? 147.293 126.424 139.930 1.00 29.10  ? 273 VAL A CB    1 
ATOM   2283 C  CG1   . VAL A 1 283 ? 147.179 125.512 138.764 1.00 35.50  ? 273 VAL A CG1   1 
ATOM   2284 C  CG2   . VAL A 1 283 ? 146.339 127.553 139.671 1.00 31.01  ? 273 VAL A CG2   1 
ATOM   2285 N  N     . ASN A 1 284 ? 146.884 123.376 141.891 1.00 40.02  ? 274 ASN A N     1 
ATOM   2286 C  CA    . ASN A 1 284 ? 147.487 122.129 142.326 1.00 42.99  ? 274 ASN A CA    1 
ATOM   2287 C  C     . ASN A 1 284 ? 146.896 120.970 141.531 1.00 46.54  ? 274 ASN A C     1 
ATOM   2288 O  O     . ASN A 1 284 ? 145.803 121.073 140.970 1.00 54.16  ? 274 ASN A O     1 
ATOM   2289 C  CB    . ASN A 1 284 ? 147.268 121.940 143.831 1.00 41.62  ? 274 ASN A CB    1 
ATOM   2290 C  CG    . ASN A 1 284 ? 148.084 120.812 144.405 1.00 47.87  ? 274 ASN A CG    1 
ATOM   2291 O  OD1   . ASN A 1 284 ? 148.815 120.127 143.690 1.00 48.07  ? 274 ASN A OD1   1 
ATOM   2292 N  ND2   . ASN A 1 284 ? 147.979 120.623 145.713 1.00 52.35  ? 274 ASN A ND2   1 
ATOM   2293 N  N     . LYS A 1 285 ? 147.633 119.861 141.485 1.00 48.77  ? 275 LYS A N     1 
ATOM   2294 C  CA    . LYS A 1 285 ? 147.297 118.773 140.571 1.00 53.84  ? 275 LYS A CA    1 
ATOM   2295 C  C     . LYS A 1 285 ? 145.929 118.174 140.877 1.00 56.00  ? 275 LYS A C     1 
ATOM   2296 O  O     . LYS A 1 285 ? 145.583 117.931 142.036 1.00 59.61  ? 275 LYS A O     1 
ATOM   2297 C  CB    . LYS A 1 285 ? 148.375 117.689 140.618 1.00 48.58  ? 275 LYS A CB    1 
ATOM   2298 C  CG    . LYS A 1 285 ? 149.490 117.911 139.619 1.00 44.76  ? 275 LYS A CG    1 
ATOM   2299 C  CD    . LYS A 1 285 ? 150.672 117.001 139.862 1.00 46.63  ? 275 LYS A CD    1 
ATOM   2300 C  CE    . LYS A 1 285 ? 150.301 115.543 139.713 1.00 48.07  ? 275 LYS A CE    1 
ATOM   2301 N  NZ    . LYS A 1 285 ? 151.452 114.665 140.055 1.00 44.51  ? 275 LYS A NZ    1 
ATOM   2302 N  N     . GLY A 1 286 ? 145.150 117.943 139.824 1.00 52.35  ? 276 GLY A N     1 
ATOM   2303 C  CA    . GLY A 1 286 ? 143.842 117.340 139.943 1.00 60.92  ? 276 GLY A CA    1 
ATOM   2304 C  C     . GLY A 1 286 ? 142.715 118.282 140.304 1.00 64.78  ? 276 GLY A C     1 
ATOM   2305 O  O     . GLY A 1 286 ? 141.566 117.832 140.399 1.00 60.03  ? 276 GLY A O     1 
ATOM   2306 N  N     . THR A 1 287 ? 142.994 119.565 140.503 1.00 61.24  ? 277 THR A N     1 
ATOM   2307 C  CA    . THR A 1 287 ? 141.967 120.514 140.901 1.00 59.98  ? 277 THR A CA    1 
ATOM   2308 C  C     . THR A 1 287 ? 141.366 121.209 139.682 1.00 60.36  ? 277 THR A C     1 
ATOM   2309 O  O     . THR A 1 287 ? 141.946 121.232 138.595 1.00 57.54  ? 277 THR A O     1 
ATOM   2310 C  CB    . THR A 1 287 ? 142.536 121.552 141.869 1.00 59.97  ? 277 THR A CB    1 
ATOM   2311 O  OG1   . THR A 1 287 ? 143.417 122.436 141.168 1.00 55.79  ? 277 THR A OG1   1 
ATOM   2312 C  CG2   . THR A 1 287 ? 143.300 120.869 142.987 1.00 56.77  ? 277 THR A CG2   1 
ATOM   2313 N  N     . LYS A 1 288 ? 140.173 121.775 139.881 1.00 61.66  ? 278 LYS A N     1 
ATOM   2314 C  CA    . LYS A 1 288 ? 139.489 122.470 138.795 1.00 63.58  ? 278 LYS A CA    1 
ATOM   2315 C  C     . LYS A 1 288 ? 140.181 123.781 138.451 1.00 58.13  ? 278 LYS A C     1 
ATOM   2316 O  O     . LYS A 1 288 ? 140.253 124.163 137.277 1.00 56.36  ? 278 LYS A O     1 
ATOM   2317 C  CB    . LYS A 1 288 ? 138.029 122.718 139.170 1.00 61.96  ? 278 LYS A CB    1 
ATOM   2318 C  CG    . LYS A 1 288 ? 137.186 121.461 139.219 1.00 62.64  ? 278 LYS A CG    1 
ATOM   2319 C  CD    . LYS A 1 288 ? 135.718 121.795 139.397 1.00 70.52  ? 278 LYS A CD    1 
ATOM   2320 C  CE    . LYS A 1 288 ? 135.446 122.372 140.774 1.00 64.66  ? 278 LYS A CE    1 
ATOM   2321 N  NZ    . LYS A 1 288 ? 134.003 122.672 140.967 1.00 64.25  ? 278 LYS A NZ    1 
ATOM   2322 N  N     . GLU A 1 289 ? 140.685 124.490 139.463 1.00 55.41  ? 279 GLU A N     1 
ATOM   2323 C  CA    . GLU A 1 289 ? 141.425 125.718 139.201 1.00 54.66  ? 279 GLU A CA    1 
ATOM   2324 C  C     . GLU A 1 289 ? 142.644 125.454 138.335 1.00 50.43  ? 279 GLU A C     1 
ATOM   2325 O  O     . GLU A 1 289 ? 143.043 126.318 137.549 1.00 50.82  ? 279 GLU A O     1 
ATOM   2326 C  CB    . GLU A 1 289 ? 141.834 126.379 140.518 1.00 56.09  ? 279 GLU A CB    1 
ATOM   2327 C  CG    . GLU A 1 289 ? 140.661 126.920 141.319 1.00 64.51  ? 279 GLU A CG    1 
ATOM   2328 C  CD    . GLU A 1 289 ? 141.074 127.555 142.632 1.00 75.27  ? 279 GLU A CD    1 
ATOM   2329 O  OE1   . GLU A 1 289 ? 142.262 127.454 142.993 1.00 73.95  ? 279 GLU A OE1   1 
ATOM   2330 O  OE2   . GLU A 1 289 ? 140.213 128.168 143.298 1.00 67.57  ? 279 GLU A OE2   1 
ATOM   2331 N  N     . ARG A 1 290 ? 143.221 124.257 138.427 1.00 49.74  ? 280 ARG A N     1 
ATOM   2332 C  CA    . ARG A 1 290 ? 144.377 123.935 137.599 1.00 45.92  ? 280 ARG A CA    1 
ATOM   2333 C  C     . ARG A 1 290 ? 143.981 123.837 136.134 1.00 47.86  ? 280 ARG A C     1 
ATOM   2334 O  O     . ARG A 1 290 ? 144.644 124.404 135.258 1.00 51.12  ? 280 ARG A O     1 
ATOM   2335 C  CB    . ARG A 1 290 ? 145.006 122.627 138.065 1.00 44.87  ? 280 ARG A CB    1 
ATOM   2336 C  CG    . ARG A 1 290 ? 146.330 122.299 137.402 1.00 42.06  ? 280 ARG A CG    1 
ATOM   2337 C  CD    . ARG A 1 290 ? 146.866 121.025 137.995 1.00 48.49  ? 280 ARG A CD    1 
ATOM   2338 N  NE    . ARG A 1 290 ? 148.147 120.596 137.450 1.00 46.11  ? 280 ARG A NE    1 
ATOM   2339 C  CZ    . ARG A 1 290 ? 149.319 120.966 137.943 1.00 39.35  ? 280 ARG A CZ    1 
ATOM   2340 N  NH1   . ARG A 1 290 ? 149.405 121.759 138.994 1.00 40.84  ? 280 ARG A NH1   1 
ATOM   2341 N  NH2   . ARG A 1 290 ? 150.432 120.495 137.391 1.00 33.51  ? 280 ARG A NH2   1 
ATOM   2342 N  N     . ASP A 1 291 ? 142.895 123.117 135.848 1.00 49.78  ? 281 ASP A N     1 
ATOM   2343 C  CA    . ASP A 1 291 ? 142.430 123.001 134.472 1.00 46.84  ? 281 ASP A CA    1 
ATOM   2344 C  C     . ASP A 1 291 ? 142.004 124.354 133.926 1.00 40.92  ? 281 ASP A C     1 
ATOM   2345 O  O     . ASP A 1 291 ? 142.280 124.678 132.767 1.00 42.65  ? 281 ASP A O     1 
ATOM   2346 C  CB    . ASP A 1 291 ? 141.287 121.995 134.387 1.00 52.87  ? 281 ASP A CB    1 
ATOM   2347 C  CG    . ASP A 1 291 ? 141.747 120.573 134.639 1.00 65.88  ? 281 ASP A CG    1 
ATOM   2348 O  OD1   . ASP A 1 291 ? 142.917 120.262 134.338 1.00 62.26  ? 281 ASP A OD1   1 
ATOM   2349 O  OD2   . ASP A 1 291 ? 140.940 119.766 135.144 1.00 77.02  ? 281 ASP A OD2   1 
ATOM   2350 N  N     . ALA A 1 292 ? 141.335 125.160 134.749 1.00 42.90  ? 282 ALA A N     1 
ATOM   2351 C  CA    . ALA A 1 292 ? 140.955 126.498 134.311 1.00 39.64  ? 282 ALA A CA    1 
ATOM   2352 C  C     . ALA A 1 292 ? 142.179 127.344 133.993 1.00 35.19  ? 282 ALA A C     1 
ATOM   2353 O  O     . ALA A 1 292 ? 142.191 128.079 133.000 1.00 32.54  ? 282 ALA A O     1 
ATOM   2354 C  CB    . ALA A 1 292 ? 140.097 127.173 135.377 1.00 39.54  ? 282 ALA A CB    1 
ATOM   2355 N  N     . PHE A 1 293 ? 143.218 127.262 134.825 1.00 41.47  ? 283 PHE A N     1 
ATOM   2356 C  CA    . PHE A 1 293 ? 144.439 128.009 134.554 1.00 37.53  ? 283 PHE A CA    1 
ATOM   2357 C  C     . PHE A 1 293 ? 145.093 127.543 133.260 1.00 37.12  ? 283 PHE A C     1 
ATOM   2358 O  O     . PHE A 1 293 ? 145.533 128.363 132.447 1.00 35.54  ? 283 PHE A O     1 
ATOM   2359 C  CB    . PHE A 1 293 ? 145.404 127.874 135.730 1.00 28.14  ? 283 PHE A CB    1 
ATOM   2360 C  CG    . PHE A 1 293 ? 146.794 128.336 135.425 1.00 27.14  ? 283 PHE A CG    1 
ATOM   2361 C  CD1   . PHE A 1 293 ? 147.032 129.631 135.018 1.00 25.60  ? 283 PHE A CD1   1 
ATOM   2362 C  CD2   . PHE A 1 293 ? 147.862 127.472 135.533 1.00 29.00  ? 283 PHE A CD2   1 
ATOM   2363 C  CE1   . PHE A 1 293 ? 148.305 130.050 134.730 1.00 24.95  ? 283 PHE A CE1   1 
ATOM   2364 C  CE2   . PHE A 1 293 ? 149.136 127.892 135.244 1.00 28.56  ? 283 PHE A CE2   1 
ATOM   2365 C  CZ    . PHE A 1 293 ? 149.356 129.179 134.843 1.00 25.20  ? 283 PHE A CZ    1 
ATOM   2366 N  N     . LEU A 1 294 ? 145.154 126.233 133.043 1.00 38.37  ? 284 LEU A N     1 
ATOM   2367 C  CA    . LEU A 1 294 ? 145.812 125.702 131.857 1.00 32.34  ? 284 LEU A CA    1 
ATOM   2368 C  C     . LEU A 1 294 ? 144.954 125.785 130.601 1.00 37.43  ? 284 LEU A C     1 
ATOM   2369 O  O     . LEU A 1 294 ? 145.468 125.539 129.506 1.00 37.77  ? 284 LEU A O     1 
ATOM   2370 C  CB    . LEU A 1 294 ? 146.227 124.254 132.099 1.00 29.15  ? 284 LEU A CB    1 
ATOM   2371 C  CG    . LEU A 1 294 ? 147.489 124.096 132.940 1.00 34.31  ? 284 LEU A CG    1 
ATOM   2372 C  CD1   . LEU A 1 294 ? 147.929 122.653 132.957 1.00 37.32  ? 284 LEU A CD1   1 
ATOM   2373 C  CD2   . LEU A 1 294 ? 148.588 124.990 132.405 1.00 34.03  ? 284 LEU A CD2   1 
ATOM   2374 N  N     . ASN A 1 295 ? 143.673 126.125 130.723 1.00 38.39  ? 285 ASN A N     1 
ATOM   2375 C  CA    . ASN A 1 295 ? 142.795 126.250 129.569 1.00 32.74  ? 285 ASN A CA    1 
ATOM   2376 C  C     . ASN A 1 295 ? 142.524 127.685 129.154 1.00 32.24  ? 285 ASN A C     1 
ATOM   2377 O  O     . ASN A 1 295 ? 142.378 127.949 127.961 1.00 36.40  ? 285 ASN A O     1 
ATOM   2378 C  CB    . ASN A 1 295 ? 141.451 125.567 129.844 1.00 36.48  ? 285 ASN A CB    1 
ATOM   2379 C  CG    . ASN A 1 295 ? 141.551 124.056 129.842 1.00 42.46  ? 285 ASN A CG    1 
ATOM   2380 O  OD1   . ASN A 1 295 ? 142.575 123.489 129.467 1.00 40.17  ? 285 ASN A OD1   1 
ATOM   2381 N  ND2   . ASN A 1 295 ? 140.482 123.396 130.263 1.00 45.03  ? 285 ASN A ND2   1 
ATOM   2382 N  N     . THR A 1 296 ? 142.458 128.618 130.102 1.00 34.10  ? 286 THR A N     1 
ATOM   2383 C  CA    . THR A 1 296 ? 141.942 129.954 129.836 1.00 33.97  ? 286 THR A CA    1 
ATOM   2384 C  C     . THR A 1 296 ? 142.913 131.043 130.265 1.00 29.54  ? 286 THR A C     1 
ATOM   2385 O  O     . THR A 1 296 ? 142.483 132.140 130.625 1.00 29.30  ? 286 THR A O     1 
ATOM   2386 C  CB    . THR A 1 296 ? 140.604 130.173 130.544 1.00 39.48  ? 286 THR A CB    1 
ATOM   2387 O  OG1   . THR A 1 296 ? 140.840 130.325 131.946 1.00 42.40  ? 286 THR A OG1   1 
ATOM   2388 C  CG2   . THR A 1 296 ? 139.664 129.002 130.327 1.00 34.72  ? 286 THR A CG2   1 
ATOM   2389 N  N     . TYR A 1 297 ? 144.214 130.775 130.249 1.00 27.62  ? 287 TYR A N     1 
ATOM   2390 C  CA    . TYR A 1 297 ? 145.157 131.765 130.748 1.00 28.73  ? 287 TYR A CA    1 
ATOM   2391 C  C     . TYR A 1 297 ? 145.361 132.875 129.726 1.00 27.56  ? 287 TYR A C     1 
ATOM   2392 O  O     . TYR A 1 297 ? 145.349 132.640 128.516 1.00 32.04  ? 287 TYR A O     1 
ATOM   2393 C  CB    . TYR A 1 297 ? 146.488 131.116 131.136 1.00 24.68  ? 287 TYR A CB    1 
ATOM   2394 C  CG    . TYR A 1 297 ? 147.299 130.501 130.019 1.00 26.48  ? 287 TYR A CG    1 
ATOM   2395 C  CD1   . TYR A 1 297 ? 148.100 131.282 129.206 1.00 25.04  ? 287 TYR A CD1   1 
ATOM   2396 C  CD2   . TYR A 1 297 ? 147.299 129.130 129.811 1.00 25.86  ? 287 TYR A CD2   1 
ATOM   2397 C  CE1   . TYR A 1 297 ? 148.848 130.725 128.201 1.00 28.15  ? 287 TYR A CE1   1 
ATOM   2398 C  CE2   . TYR A 1 297 ? 148.049 128.564 128.806 1.00 29.67  ? 287 TYR A CE2   1 
ATOM   2399 C  CZ    . TYR A 1 297 ? 148.824 129.368 128.006 1.00 31.72  ? 287 TYR A CZ    1 
ATOM   2400 O  OH    . TYR A 1 297 ? 149.580 128.820 127.000 1.00 31.70  ? 287 TYR A OH    1 
ATOM   2401 N  N     . GLY A 1 298 ? 145.537 134.094 130.225 1.00 24.77  ? 288 GLY A N     1 
ATOM   2402 C  CA    . GLY A 1 298 ? 145.572 135.267 129.384 1.00 23.87  ? 288 GLY A CA    1 
ATOM   2403 C  C     . GLY A 1 298 ? 146.923 135.513 128.756 1.00 27.84  ? 288 GLY A C     1 
ATOM   2404 O  O     . GLY A 1 298 ? 147.884 134.772 128.947 1.00 26.96  ? 288 GLY A O     1 
ATOM   2405 N  N     . GLU A 1 299 ? 146.991 136.599 127.993 1.00 27.66  ? 289 GLU A N     1 
ATOM   2406 C  CA    . GLU A 1 299 ? 148.175 136.925 127.213 1.00 29.25  ? 289 GLU A CA    1 
ATOM   2407 C  C     . GLU A 1 299 ? 149.171 137.807 127.949 1.00 27.26  ? 289 GLU A C     1 
ATOM   2408 O  O     . GLU A 1 299 ? 150.255 138.058 127.415 1.00 28.12  ? 289 GLU A O     1 
ATOM   2409 C  CB    . GLU A 1 299 ? 147.770 137.610 125.907 1.00 26.04  ? 289 GLU A CB    1 
ATOM   2410 C  CG    . GLU A 1 299 ? 146.863 136.767 125.038 1.00 29.30  ? 289 GLU A CG    1 
ATOM   2411 C  CD    . GLU A 1 299 ? 146.731 137.309 123.637 1.00 33.47  ? 289 GLU A CD    1 
ATOM   2412 O  OE1   . GLU A 1 299 ? 147.339 138.357 123.343 1.00 29.90  ? 289 GLU A OE1   1 
ATOM   2413 O  OE2   . GLU A 1 299 ? 146.023 136.683 122.824 1.00 36.40  ? 289 GLU A OE2   1 
ATOM   2414 N  N     . ASN A 1 300 ? 148.847 138.278 129.149 1.00 25.72  ? 290 ASN A N     1 
ATOM   2415 C  CA    . ASN A 1 300 ? 149.750 139.143 129.893 1.00 23.86  ? 290 ASN A CA    1 
ATOM   2416 C  C     . ASN A 1 300 ? 150.647 138.318 130.803 1.00 24.49  ? 290 ASN A C     1 
ATOM   2417 O  O     . ASN A 1 300 ? 150.170 137.458 131.548 1.00 22.81  ? 290 ASN A O     1 
ATOM   2418 C  CB    . ASN A 1 300 ? 148.975 140.180 130.706 1.00 21.33  ? 290 ASN A CB    1 
ATOM   2419 C  CG    . ASN A 1 300 ? 147.957 139.563 131.622 1.00 27.39  ? 290 ASN A CG    1 
ATOM   2420 O  OD1   . ASN A 1 300 ? 147.383 138.521 131.322 1.00 32.48  ? 290 ASN A OD1   1 
ATOM   2421 N  ND2   . ASN A 1 300 ? 147.718 140.212 132.752 1.00 23.29  ? 290 ASN A ND2   1 
ATOM   2422 N  N     . ILE A 1 301 ? 151.947 138.579 130.728 1.00 26.62  ? 291 ILE A N     1 
ATOM   2423 C  CA    . ILE A 1 301 ? 152.943 137.932 131.568 1.00 21.00  ? 291 ILE A CA    1 
ATOM   2424 C  C     . ILE A 1 301 ? 153.660 139.021 132.350 1.00 23.35  ? 291 ILE A C     1 
ATOM   2425 O  O     . ILE A 1 301 ? 154.216 139.953 131.759 1.00 27.03  ? 291 ILE A O     1 
ATOM   2426 C  CB    . ILE A 1 301 ? 153.940 137.108 130.742 1.00 18.75  ? 291 ILE A CB    1 
ATOM   2427 C  CG1   . ILE A 1 301 ? 153.200 136.120 129.846 1.00 25.92  ? 291 ILE A CG1   1 
ATOM   2428 C  CG2   . ILE A 1 301 ? 154.900 136.378 131.654 1.00 19.45  ? 291 ILE A CG2   1 
ATOM   2429 C  CD1   . ILE A 1 301 ? 154.084 135.447 128.840 1.00 25.60  ? 291 ILE A CD1   1 
ATOM   2430 N  N     . VAL A 1 302 ? 153.648 138.902 133.672 1.00 22.43  ? 292 VAL A N     1 
ATOM   2431 C  CA    . VAL A 1 302 ? 154.266 139.874 134.564 1.00 16.59  ? 292 VAL A CA    1 
ATOM   2432 C  C     . VAL A 1 302 ? 155.464 139.206 135.220 1.00 18.58  ? 292 VAL A C     1 
ATOM   2433 O  O     . VAL A 1 302 ? 155.310 138.224 135.953 1.00 19.92  ? 292 VAL A O     1 
ATOM   2434 C  CB    . VAL A 1 302 ? 153.271 140.381 135.620 1.00 14.84  ? 292 VAL A CB    1 
ATOM   2435 C  CG1   . VAL A 1 302 ? 153.949 141.329 136.587 1.00 17.18  ? 292 VAL A CG1   1 
ATOM   2436 C  CG2   . VAL A 1 302 ? 152.081 141.041 134.960 1.00 17.73  ? 292 VAL A CG2   1 
ATOM   2437 N  N     . PHE A 1 303 ? 156.653 139.732 134.958 1.00 18.84  ? 293 PHE A N     1 
ATOM   2438 C  CA    . PHE A 1 303 ? 157.868 139.296 135.632 1.00 18.72  ? 293 PHE A CA    1 
ATOM   2439 C  C     . PHE A 1 303 ? 158.180 140.303 136.729 1.00 20.73  ? 293 PHE A C     1 
ATOM   2440 O  O     . PHE A 1 303 ? 158.316 141.497 136.454 1.00 27.92  ? 293 PHE A O     1 
ATOM   2441 C  CB    . PHE A 1 303 ? 159.038 139.182 134.655 1.00 19.47  ? 293 PHE A CB    1 
ATOM   2442 C  CG    . PHE A 1 303 ? 158.896 138.062 133.673 1.00 19.37  ? 293 PHE A CG    1 
ATOM   2443 C  CD1   . PHE A 1 303 ? 159.223 136.772 134.024 1.00 19.00  ? 293 PHE A CD1   1 
ATOM   2444 C  CD2   . PHE A 1 303 ? 158.433 138.303 132.396 1.00 21.16  ? 293 PHE A CD2   1 
ATOM   2445 C  CE1   . PHE A 1 303 ? 159.085 135.741 133.123 1.00 23.80  ? 293 PHE A CE1   1 
ATOM   2446 C  CE2   . PHE A 1 303 ? 158.295 137.275 131.493 1.00 22.44  ? 293 PHE A CE2   1 
ATOM   2447 C  CZ    . PHE A 1 303 ? 158.622 135.991 131.858 1.00 25.11  ? 293 PHE A CZ    1 
ATOM   2448 N  N     . ILE A 1 304 ? 158.285 139.827 137.963 1.00 19.82  ? 294 ILE A N     1 
ATOM   2449 C  CA    . ILE A 1 304 ? 158.490 140.698 139.113 1.00 23.74  ? 294 ILE A CA    1 
ATOM   2450 C  C     . ILE A 1 304 ? 159.538 140.077 140.026 1.00 27.70  ? 294 ILE A C     1 
ATOM   2451 O  O     . ILE A 1 304 ? 159.588 138.854 140.187 1.00 35.23  ? 294 ILE A O     1 
ATOM   2452 C  CB    . ILE A 1 304 ? 157.159 140.963 139.852 1.00 21.65  ? 294 ILE A CB    1 
ATOM   2453 C  CG1   . ILE A 1 304 ? 157.330 142.064 140.898 1.00 26.29  ? 294 ILE A CG1   1 
ATOM   2454 C  CG2   . ILE A 1 304 ? 156.611 139.697 140.464 1.00 19.70  ? 294 ILE A CG2   1 
ATOM   2455 C  CD1   . ILE A 1 304 ? 156.033 142.605 141.422 1.00 24.23  ? 294 ILE A CD1   1 
ATOM   2456 N  N     . ILE A 1 305 ? 160.395 140.916 140.600 1.00 25.67  ? 295 ILE A N     1 
ATOM   2457 C  CA    . ILE A 1 305 ? 161.454 140.472 141.502 1.00 29.99  ? 295 ILE A CA    1 
ATOM   2458 C  C     . ILE A 1 305 ? 161.125 140.954 142.908 1.00 37.80  ? 295 ILE A C     1 
ATOM   2459 O  O     . ILE A 1 305 ? 160.910 142.151 143.129 1.00 32.81  ? 295 ILE A O     1 
ATOM   2460 C  CB    . ILE A 1 305 ? 162.833 140.976 141.055 1.00 28.87  ? 295 ILE A CB    1 
ATOM   2461 C  CG1   . ILE A 1 305 ? 163.201 140.366 139.709 1.00 30.57  ? 295 ILE A CG1   1 
ATOM   2462 C  CG2   . ILE A 1 305 ? 163.881 140.627 142.081 1.00 32.31  ? 295 ILE A CG2   1 
ATOM   2463 C  CD1   . ILE A 1 305 ? 164.560 140.738 139.230 1.00 37.55  ? 295 ILE A CD1   1 
ATOM   2464 N  N     . ASN A 1 306 ? 161.088 140.021 143.858 1.00 41.34  ? 296 ASN A N     1 
ATOM   2465 C  CA    . ASN A 1 306 ? 160.765 140.320 145.248 1.00 38.47  ? 296 ASN A CA    1 
ATOM   2466 C  C     . ASN A 1 306 ? 161.755 139.599 146.148 1.00 43.82  ? 296 ASN A C     1 
ATOM   2467 O  O     . ASN A 1 306 ? 161.774 138.365 146.187 1.00 46.88  ? 296 ASN A O     1 
ATOM   2468 C  CB    . ASN A 1 306 ? 159.331 139.903 145.580 1.00 36.73  ? 296 ASN A CB    1 
ATOM   2469 C  CG    . ASN A 1 306 ? 158.803 140.584 146.820 1.00 44.15  ? 296 ASN A CG    1 
ATOM   2470 O  OD1   . ASN A 1 306 ? 159.530 141.303 147.502 1.00 50.06  ? 296 ASN A OD1   1 
ATOM   2471 N  ND2   . ASN A 1 306 ? 157.530 140.371 147.115 1.00 44.07  ? 296 ASN A ND2   1 
ATOM   2472 N  N     . ASN A 1 307 ? 162.562 140.371 146.878 1.00 47.42  ? 297 ASN A N     1 
ATOM   2473 C  CA    . ASN A 1 307 ? 163.627 139.841 147.732 1.00 48.17  ? 297 ASN A CA    1 
ATOM   2474 C  C     . ASN A 1 307 ? 164.629 139.022 146.922 1.00 54.35  ? 297 ASN A C     1 
ATOM   2475 O  O     . ASN A 1 307 ? 164.984 137.898 147.280 1.00 55.07  ? 297 ASN A O     1 
ATOM   2476 C  CB    . ASN A 1 307 ? 163.055 139.022 148.889 1.00 46.72  ? 297 ASN A CB    1 
ATOM   2477 C  CG    . ASN A 1 307 ? 162.142 139.832 149.775 1.00 48.23  ? 297 ASN A CG    1 
ATOM   2478 O  OD1   . ASN A 1 307 ? 162.003 141.041 149.599 1.00 45.57  ? 297 ASN A OD1   1 
ATOM   2479 N  ND2   . ASN A 1 307 ? 161.510 139.170 150.736 1.00 48.25  ? 297 ASN A ND2   1 
ATOM   2480 N  N     . ASP A 1 308 ? 165.085 139.607 145.814 1.00 56.33  ? 298 ASP A N     1 
ATOM   2481 C  CA    . ASP A 1 308 ? 166.096 138.999 144.947 1.00 53.56  ? 298 ASP A CA    1 
ATOM   2482 C  C     . ASP A 1 308 ? 165.658 137.626 144.447 1.00 47.34  ? 298 ASP A C     1 
ATOM   2483 O  O     . ASP A 1 308 ? 166.472 136.717 144.281 1.00 50.62  ? 298 ASP A O     1 
ATOM   2484 C  CB    . ASP A 1 308 ? 167.452 138.915 145.651 1.00 51.68  ? 298 ASP A CB    1 
ATOM   2485 C  CG    . ASP A 1 308 ? 168.103 140.272 145.819 1.00 60.09  ? 298 ASP A CG    1 
ATOM   2486 O  OD1   . ASP A 1 308 ? 167.390 141.289 145.707 1.00 66.34  ? 298 ASP A OD1   1 
ATOM   2487 O  OD2   . ASP A 1 308 ? 169.327 140.322 146.058 1.00 63.42  ? 298 ASP A OD2   1 
ATOM   2488 N  N     . GLU A 1 309 ? 164.362 137.475 144.200 1.00 47.02  ? 299 GLU A N     1 
ATOM   2489 C  CA    . GLU A 1 309 ? 163.817 136.258 143.619 1.00 43.16  ? 299 GLU A CA    1 
ATOM   2490 C  C     . GLU A 1 309 ? 162.839 136.627 142.520 1.00 32.76  ? 299 GLU A C     1 
ATOM   2491 O  O     . GLU A 1 309 ? 162.050 137.561 142.672 1.00 37.09  ? 299 GLU A O     1 
ATOM   2492 C  CB    . GLU A 1 309 ? 163.125 135.390 144.673 1.00 42.89  ? 299 GLU A CB    1 
ATOM   2493 C  CG    . GLU A 1 309 ? 164.072 134.480 145.424 1.00 46.48  ? 299 GLU A CG    1 
ATOM   2494 C  CD    . GLU A 1 309 ? 163.434 133.867 146.643 1.00 56.12  ? 299 GLU A CD    1 
ATOM   2495 O  OE1   . GLU A 1 309 ? 162.576 134.532 147.256 1.00 58.92  ? 299 GLU A OE1   1 
ATOM   2496 O  OE2   . GLU A 1 309 ? 163.783 132.719 146.986 1.00 65.41  ? 299 GLU A OE2   1 
ATOM   2497 N  N     . LEU A 1 310 ? 162.889 135.887 141.418 1.00 28.65  ? 300 LEU A N     1 
ATOM   2498 C  CA    . LEU A 1 310 ? 162.046 136.161 140.265 1.00 29.27  ? 300 LEU A CA    1 
ATOM   2499 C  C     . LEU A 1 310 ? 160.723 135.423 140.396 1.00 25.71  ? 300 LEU A C     1 
ATOM   2500 O  O     . LEU A 1 310 ? 160.699 134.213 140.638 1.00 25.60  ? 300 LEU A O     1 
ATOM   2501 C  CB    . LEU A 1 310 ? 162.749 135.745 138.974 1.00 29.20  ? 300 LEU A CB    1 
ATOM   2502 C  CG    . LEU A 1 310 ? 162.089 136.158 137.662 1.00 25.58  ? 300 LEU A CG    1 
ATOM   2503 C  CD1   . LEU A 1 310 ? 162.133 137.666 137.504 1.00 30.08  ? 300 LEU A CD1   1 
ATOM   2504 C  CD2   . LEU A 1 310 ? 162.751 135.469 136.493 1.00 29.62  ? 300 LEU A CD2   1 
ATOM   2505 N  N     . TYR A 1 311 ? 159.628 136.156 140.233 1.00 22.96  ? 301 TYR A N     1 
ATOM   2506 C  CA    . TYR A 1 311 ? 158.289 135.595 140.200 1.00 20.54  ? 301 TYR A CA    1 
ATOM   2507 C  C     . TYR A 1 311 ? 157.639 135.932 138.868 1.00 20.35  ? 301 TYR A C     1 
ATOM   2508 O  O     . TYR A 1 311 ? 157.976 136.934 138.234 1.00 21.55  ? 301 TYR A O     1 
ATOM   2509 C  CB    . TYR A 1 311 ? 157.428 136.129 141.343 1.00 19.02  ? 301 TYR A CB    1 
ATOM   2510 C  CG    . TYR A 1 311 ? 157.942 135.761 142.706 1.00 22.89  ? 301 TYR A CG    1 
ATOM   2511 C  CD1   . TYR A 1 311 ? 158.886 136.544 143.343 1.00 24.84  ? 301 TYR A CD1   1 
ATOM   2512 C  CD2   . TYR A 1 311 ? 157.480 134.632 143.357 1.00 25.86  ? 301 TYR A CD2   1 
ATOM   2513 C  CE1   . TYR A 1 311 ? 159.360 136.211 144.581 1.00 28.18  ? 301 TYR A CE1   1 
ATOM   2514 C  CE2   . TYR A 1 311 ? 157.948 134.291 144.598 1.00 24.44  ? 301 TYR A CE2   1 
ATOM   2515 C  CZ    . TYR A 1 311 ? 158.888 135.084 145.206 1.00 30.28  ? 301 TYR A CZ    1 
ATOM   2516 O  OH    . TYR A 1 311 ? 159.360 134.749 146.451 1.00 39.34  ? 301 TYR A OH    1 
ATOM   2517 N  N     . VAL A 1 312 ? 156.710 135.084 138.439 1.00 17.98  ? 302 VAL A N     1 
ATOM   2518 C  CA    . VAL A 1 312 ? 155.998 135.278 137.183 1.00 15.90  ? 302 VAL A CA    1 
ATOM   2519 C  C     . VAL A 1 312 ? 154.506 135.215 137.473 1.00 16.81  ? 302 VAL A C     1 
ATOM   2520 O  O     . VAL A 1 312 ? 154.027 134.242 138.063 1.00 19.78  ? 302 VAL A O     1 
ATOM   2521 C  CB    . VAL A 1 312 ? 156.387 134.220 136.137 1.00 16.45  ? 302 VAL A CB    1 
ATOM   2522 C  CG1   . VAL A 1 312 ? 155.625 134.451 134.867 1.00 18.01  ? 302 VAL A CG1   1 
ATOM   2523 C  CG2   . VAL A 1 312 ? 157.871 134.217 135.896 1.00 19.11  ? 302 VAL A CG2   1 
ATOM   2524 N  N     . VAL A 1 313 ? 153.773 136.240 137.050 1.00 17.54  ? 303 VAL A N     1 
ATOM   2525 C  CA    . VAL A 1 313 ? 152.340 136.338 137.297 1.00 15.56  ? 303 VAL A CA    1 
ATOM   2526 C  C     . VAL A 1 313 ? 151.604 136.129 135.984 1.00 17.50  ? 303 VAL A C     1 
ATOM   2527 O  O     . VAL A 1 313 ? 151.865 136.826 134.999 1.00 19.68  ? 303 VAL A O     1 
ATOM   2528 C  CB    . VAL A 1 313 ? 151.960 137.692 137.918 1.00 14.37  ? 303 VAL A CB    1 
ATOM   2529 C  CG1   . VAL A 1 313 ? 150.530 137.664 138.391 1.00 16.20  ? 303 VAL A CG1   1 
ATOM   2530 C  CG2   . VAL A 1 313 ? 152.900 138.048 139.049 1.00 15.70  ? 303 VAL A CG2   1 
ATOM   2531 N  N     . PHE A 1 314 ? 150.691 135.170 135.975 1.00 19.80  ? 304 PHE A N     1 
ATOM   2532 C  CA    . PHE A 1 314 ? 149.785 134.933 134.866 1.00 18.06  ? 304 PHE A CA    1 
ATOM   2533 C  C     . PHE A 1 314 ? 148.366 135.287 135.286 1.00 22.40  ? 304 PHE A C     1 
ATOM   2534 O  O     . PHE A 1 314 ? 148.068 135.486 136.463 1.00 27.70  ? 304 PHE A O     1 
ATOM   2535 C  CB    . PHE A 1 314 ? 149.857 133.477 134.394 1.00 17.59  ? 304 PHE A CB    1 
ATOM   2536 C  CG    . PHE A 1 314 ? 151.226 133.047 133.958 1.00 21.60  ? 304 PHE A CG    1 
ATOM   2537 C  CD1   . PHE A 1 314 ? 151.796 133.569 132.815 1.00 22.58  ? 304 PHE A CD1   1 
ATOM   2538 C  CD2   . PHE A 1 314 ? 151.939 132.117 134.685 1.00 22.78  ? 304 PHE A CD2   1 
ATOM   2539 C  CE1   . PHE A 1 314 ? 153.046 133.178 132.414 1.00 20.30  ? 304 PHE A CE1   1 
ATOM   2540 C  CE2   . PHE A 1 314 ? 153.191 131.724 134.286 1.00 18.57  ? 304 PHE A CE2   1 
ATOM   2541 C  CZ    . PHE A 1 314 ? 153.742 132.251 133.148 1.00 17.26  ? 304 PHE A CZ    1 
ATOM   2542 N  N     . SER A 1 315 ? 147.488 135.373 134.297 1.00 26.28  ? 305 SER A N     1 
ATOM   2543 C  CA    . SER A 1 315 ? 146.090 135.693 134.519 1.00 24.19  ? 305 SER A CA    1 
ATOM   2544 C  C     . SER A 1 315 ? 145.225 134.658 133.828 1.00 28.81  ? 305 SER A C     1 
ATOM   2545 O  O     . SER A 1 315 ? 145.646 134.027 132.859 1.00 33.37  ? 305 SER A O     1 
ATOM   2546 C  CB    . SER A 1 315 ? 145.735 137.076 133.998 1.00 24.98  ? 305 SER A CB    1 
ATOM   2547 O  OG    . SER A 1 315 ? 144.509 137.502 134.546 1.00 30.86  ? 305 SER A OG    1 
ATOM   2548 N  N     . TYR A 1 316 ? 144.012 134.489 134.334 1.00 27.64  ? 306 TYR A N     1 
ATOM   2549 C  CA    . TYR A 1 316 ? 143.088 133.523 133.763 1.00 31.29  ? 306 TYR A CA    1 
ATOM   2550 C  C     . TYR A 1 316 ? 141.675 133.903 134.178 1.00 38.50  ? 306 TYR A C     1 
ATOM   2551 O  O     . TYR A 1 316 ? 141.460 134.859 134.926 1.00 37.14  ? 306 TYR A O     1 
ATOM   2552 C  CB    . TYR A 1 316 ? 143.448 132.095 134.183 1.00 34.45  ? 306 TYR A CB    1 
ATOM   2553 C  CG    . TYR A 1 316 ? 143.349 131.795 135.663 1.00 32.78  ? 306 TYR A CG    1 
ATOM   2554 C  CD1   . TYR A 1 316 ? 144.183 132.413 136.582 1.00 31.85  ? 306 TYR A CD1   1 
ATOM   2555 C  CD2   . TYR A 1 316 ? 142.440 130.863 136.135 1.00 38.83  ? 306 TYR A CD2   1 
ATOM   2556 C  CE1   . TYR A 1 316 ? 144.095 132.127 137.921 1.00 31.83  ? 306 TYR A CE1   1 
ATOM   2557 C  CE2   . TYR A 1 316 ? 142.350 130.571 137.467 1.00 41.19  ? 306 TYR A CE2   1 
ATOM   2558 C  CZ    . TYR A 1 316 ? 143.177 131.203 138.357 1.00 38.28  ? 306 TYR A CZ    1 
ATOM   2559 O  OH    . TYR A 1 316 ? 143.078 130.905 139.693 1.00 42.07  ? 306 TYR A OH    1 
ATOM   2560 N  N     . GLU A 1 317 ? 140.708 133.150 133.665 1.00 46.52  ? 307 GLU A N     1 
ATOM   2561 C  CA    . GLU A 1 317 ? 139.298 133.336 133.970 1.00 41.78  ? 307 GLU A CA    1 
ATOM   2562 C  C     . GLU A 1 317 ? 138.817 132.162 134.804 1.00 47.59  ? 307 GLU A C     1 
ATOM   2563 O  O     . GLU A 1 317 ? 138.970 131.006 134.399 1.00 46.77  ? 307 GLU A O     1 
ATOM   2564 C  CB    . GLU A 1 317 ? 138.470 133.443 132.690 1.00 38.27  ? 307 GLU A CB    1 
ATOM   2565 C  CG    . GLU A 1 317 ? 138.962 134.498 131.713 1.00 47.02  ? 307 GLU A CG    1 
ATOM   2566 C  CD    . GLU A 1 317 ? 138.344 134.348 130.336 1.00 59.04  ? 307 GLU A CD    1 
ATOM   2567 O  OE1   . GLU A 1 317 ? 137.620 133.355 130.114 1.00 59.37  ? 307 GLU A OE1   1 
ATOM   2568 O  OE2   . GLU A 1 317 ? 138.584 135.220 129.475 1.00 69.16  ? 307 GLU A OE2   1 
ATOM   2569 N  N     . TYR A 1 318 ? 138.239 132.458 135.964 1.00 56.53  ? 308 TYR A N     1 
ATOM   2570 C  CA    . TYR A 1 318 ? 137.675 131.416 136.817 1.00 63.82  ? 308 TYR A CA    1 
ATOM   2571 C  C     . TYR A 1 318 ? 136.667 132.059 137.748 1.00 71.41  ? 308 TYR A C     1 
ATOM   2572 O  O     . TYR A 1 318 ? 137.021 132.965 138.507 1.00 75.19  ? 308 TYR A O     1 
ATOM   2573 C  CB    . TYR A 1 318 ? 138.757 130.708 137.621 1.00 53.30  ? 308 TYR A CB    1 
ATOM   2574 C  CG    . TYR A 1 318 ? 138.260 129.478 138.337 1.00 62.53  ? 308 TYR A CG    1 
ATOM   2575 C  CD1   . TYR A 1 318 ? 137.837 128.367 137.626 1.00 67.13  ? 308 TYR A CD1   1 
ATOM   2576 C  CD2   . TYR A 1 318 ? 138.195 129.430 139.720 1.00 68.49  ? 308 TYR A CD2   1 
ATOM   2577 C  CE1   . TYR A 1 318 ? 137.379 127.239 138.268 1.00 68.31  ? 308 TYR A CE1   1 
ATOM   2578 C  CE2   . TYR A 1 318 ? 137.734 128.306 140.372 1.00 72.47  ? 308 TYR A CE2   1 
ATOM   2579 C  CZ    . TYR A 1 318 ? 137.332 127.211 139.640 1.00 74.56  ? 308 TYR A CZ    1 
ATOM   2580 O  OH    . TYR A 1 318 ? 136.875 126.082 140.277 1.00 77.29  ? 308 TYR A OH    1 
ATOM   2581 N  N     . GLU A 1 319 ? 135.422 131.599 137.691 1.00 77.69  ? 309 GLU A N     1 
ATOM   2582 C  CA    . GLU A 1 319 ? 134.384 132.027 138.618 1.00 83.84  ? 309 GLU A CA    1 
ATOM   2583 C  C     . GLU A 1 319 ? 133.785 130.791 139.266 1.00 90.42  ? 309 GLU A C     1 
ATOM   2584 O  O     . GLU A 1 319 ? 133.345 129.871 138.569 1.00 87.01  ? 309 GLU A O     1 
ATOM   2585 C  CB    . GLU A 1 319 ? 133.310 132.852 137.908 1.00 86.06  ? 309 GLU A CB    1 
ATOM   2586 C  CG    . GLU A 1 319 ? 133.720 134.297 137.667 1.00 87.99  ? 309 GLU A CG    1 
ATOM   2587 C  CD    . GLU A 1 319 ? 132.740 135.054 136.791 1.00 92.53  ? 309 GLU A CD    1 
ATOM   2588 O  OE1   . GLU A 1 319 ? 131.909 134.405 136.120 1.00 91.46  ? 309 GLU A OE1   1 
ATOM   2589 O  OE2   . GLU A 1 319 ? 132.799 136.301 136.777 1.00 81.05  ? 309 GLU A OE2   1 
ATOM   2590 N  N     . LEU A 1 320 ? 133.780 130.768 140.594 1.00 93.17  ? 310 LEU A N     1 
ATOM   2591 C  CA    . LEU A 1 320 ? 133.222 129.647 141.328 1.00 95.35  ? 310 LEU A CA    1 
ATOM   2592 C  C     . LEU A 1 320 ? 131.703 129.766 141.412 1.00 101.57 ? 310 LEU A C     1 
ATOM   2593 O  O     . LEU A 1 320 ? 131.121 130.828 141.180 1.00 100.93 ? 310 LEU A O     1 
ATOM   2594 C  CB    . LEU A 1 320 ? 133.829 129.569 142.726 1.00 89.20  ? 310 LEU A CB    1 
ATOM   2595 C  CG    . LEU A 1 320 ? 135.078 128.699 142.828 1.00 83.84  ? 310 LEU A CG    1 
ATOM   2596 C  CD1   . LEU A 1 320 ? 135.589 128.664 144.253 1.00 77.62  ? 310 LEU A CD1   1 
ATOM   2597 C  CD2   . LEU A 1 320 ? 134.770 127.301 142.331 1.00 81.28  ? 310 LEU A CD2   1 
ATOM   2598 N  N     . GLU A 1 321 ? 131.061 128.650 141.745 1.00 103.59 ? 311 GLU A N     1 
ATOM   2599 C  CA    . GLU A 1 321 ? 129.606 128.570 141.801 1.00 109.84 ? 311 GLU A CA    1 
ATOM   2600 C  C     . GLU A 1 321 ? 129.164 128.745 143.249 1.00 112.12 ? 311 GLU A C     1 
ATOM   2601 O  O     . GLU A 1 321 ? 129.374 127.859 144.085 1.00 110.89 ? 311 GLU A O     1 
ATOM   2602 C  CB    . GLU A 1 321 ? 129.114 127.247 141.220 1.00 109.13 ? 311 GLU A CB    1 
ATOM   2603 C  CG    . GLU A 1 321 ? 129.612 126.985 139.806 1.00 107.71 ? 311 GLU A CG    1 
ATOM   2604 C  CD    . GLU A 1 321 ? 129.583 128.230 138.932 1.00 104.98 ? 311 GLU A CD    1 
ATOM   2605 O  OE1   . GLU A 1 321 ? 128.526 128.894 138.862 1.00 98.88  ? 311 GLU A OE1   1 
ATOM   2606 O  OE2   . GLU A 1 321 ? 130.626 128.554 138.324 1.00 101.71 ? 311 GLU A OE2   1 
ATOM   2607 N  N     . LYS A 1 322 ? 128.548 129.889 143.537 1.00 114.68 ? 312 LYS A N     1 
ATOM   2608 C  CA    . LYS A 1 322 ? 128.178 130.236 144.903 1.00 115.53 ? 312 LYS A CA    1 
ATOM   2609 C  C     . LYS A 1 322 ? 126.993 129.394 145.357 1.00 121.23 ? 312 LYS A C     1 
ATOM   2610 O  O     . LYS A 1 322 ? 125.916 129.448 144.754 1.00 119.95 ? 312 LYS A O     1 
ATOM   2611 C  CB    . LYS A 1 322 ? 127.846 131.723 144.984 1.00 112.78 ? 312 LYS A CB    1 
ATOM   2612 C  CG    . LYS A 1 322 ? 128.853 132.610 144.275 1.00 111.07 ? 312 LYS A CG    1 
ATOM   2613 C  CD    . LYS A 1 322 ? 128.325 134.020 144.088 1.00 108.40 ? 312 LYS A CD    1 
ATOM   2614 C  CE    . LYS A 1 322 ? 129.241 134.832 143.183 1.00 104.01 ? 312 LYS A CE    1 
ATOM   2615 N  NZ    . LYS A 1 322 ? 128.645 136.148 142.827 1.00 98.42  ? 312 LYS A NZ    1 
ATOM   2616 N  N     . GLU A 1 323 ? 127.190 128.622 146.423 1.00 122.68 ? 313 GLU A N     1 
ATOM   2617 C  CA    . GLU A 1 323 ? 126.146 127.777 146.993 1.00 121.33 ? 313 GLU A CA    1 
ATOM   2618 C  C     . GLU A 1 323 ? 125.470 128.547 148.121 1.00 123.13 ? 313 GLU A C     1 
ATOM   2619 O  O     . GLU A 1 323 ? 126.069 128.764 149.180 1.00 123.04 ? 313 GLU A O     1 
ATOM   2620 C  CB    . GLU A 1 323 ? 126.729 126.458 147.492 1.00 119.87 ? 313 GLU A CB    1 
ATOM   2621 C  CG    . GLU A 1 323 ? 127.160 125.518 146.380 1.00 121.40 ? 313 GLU A CG    1 
ATOM   2622 C  CD    . GLU A 1 323 ? 127.777 124.238 146.904 1.00 125.46 ? 313 GLU A CD    1 
ATOM   2623 O  OE1   . GLU A 1 323 ? 128.230 124.227 148.068 1.00 126.80 ? 313 GLU A OE1   1 
ATOM   2624 O  OE2   . GLU A 1 323 ? 127.809 123.241 146.151 1.00 121.89 ? 313 GLU A OE2   1 
ATOM   2625 N  N     . GLU A 1 324 ? 124.226 128.955 147.894 1.00 121.15 ? 314 GLU A N     1 
ATOM   2626 C  CA    . GLU A 1 324 ? 123.520 129.794 148.849 1.00 119.88 ? 314 GLU A CA    1 
ATOM   2627 C  C     . GLU A 1 324 ? 123.017 128.972 150.035 1.00 123.53 ? 314 GLU A C     1 
ATOM   2628 O  O     . GLU A 1 324 ? 122.991 127.739 150.012 1.00 121.16 ? 314 GLU A O     1 
ATOM   2629 C  CB    . GLU A 1 324 ? 122.351 130.504 148.169 1.00 115.46 ? 314 GLU A CB    1 
ATOM   2630 C  CG    . GLU A 1 324 ? 122.745 131.286 146.931 1.00 115.63 ? 314 GLU A CG    1 
ATOM   2631 C  CD    . GLU A 1 324 ? 121.547 131.741 146.121 1.00 115.60 ? 314 GLU A CD    1 
ATOM   2632 O  OE1   . GLU A 1 324 ? 120.403 131.508 146.563 1.00 114.18 ? 314 GLU A OE1   1 
ATOM   2633 O  OE2   . GLU A 1 324 ? 121.751 132.332 145.039 1.00 114.06 ? 314 GLU A OE2   1 
ATOM   2634 N  N     . ALA A 1 325 ? 122.623 129.685 151.088 1.00 124.13 ? 315 ALA A N     1 
ATOM   2635 C  CA    . ALA A 1 325 ? 122.064 129.086 152.290 1.00 112.97 ? 315 ALA A CA    1 
ATOM   2636 C  C     . ALA A 1 325 ? 120.879 129.918 152.759 1.00 109.96 ? 315 ALA A C     1 
ATOM   2637 O  O     . ALA A 1 325 ? 120.761 131.104 152.442 1.00 108.27 ? 315 ALA A O     1 
ATOM   2638 C  CB    . ALA A 1 325 ? 123.111 128.975 153.406 1.00 101.01 ? 315 ALA A CB    1 
ATOM   2639 N  N     . ASN A 1 326 ? 119.992 129.278 153.517 1.00 110.91 ? 316 ASN A N     1 
ATOM   2640 C  CA    . ASN A 1 326 ? 118.782 129.948 153.977 1.00 110.55 ? 316 ASN A CA    1 
ATOM   2641 C  C     . ASN A 1 326 ? 119.124 131.050 154.972 1.00 104.34 ? 316 ASN A C     1 
ATOM   2642 O  O     . ASN A 1 326 ? 119.964 130.865 155.857 1.00 97.39  ? 316 ASN A O     1 
ATOM   2643 C  CB    . ASN A 1 326 ? 117.825 128.941 154.613 1.00 108.85 ? 316 ASN A CB    1 
ATOM   2644 C  CG    . ASN A 1 326 ? 116.581 129.600 155.176 1.00 109.61 ? 316 ASN A CG    1 
ATOM   2645 O  OD1   . ASN A 1 326 ? 116.082 130.580 154.624 1.00 106.28 ? 316 ASN A OD1   1 
ATOM   2646 N  ND2   . ASN A 1 326 ? 116.078 129.069 156.284 1.00 109.46 ? 316 ASN A ND2   1 
ATOM   2647 N  N     . PHE A 1 327 ? 118.463 132.198 154.827 1.00 103.54 ? 317 PHE A N     1 
ATOM   2648 C  CA    . PHE A 1 327 ? 118.703 133.324 155.720 1.00 101.72 ? 317 PHE A CA    1 
ATOM   2649 C  C     . PHE A 1 327 ? 118.282 132.985 157.144 1.00 93.02  ? 317 PHE A C     1 
ATOM   2650 O  O     . PHE A 1 327 ? 117.176 132.489 157.379 1.00 92.50  ? 317 PHE A O     1 
ATOM   2651 C  CB    . PHE A 1 327 ? 117.961 134.566 155.227 1.00 104.93 ? 317 PHE A CB    1 
ATOM   2652 C  CG    . PHE A 1 327 ? 118.605 135.228 154.040 1.00 105.71 ? 317 PHE A CG    1 
ATOM   2653 C  CD1   . PHE A 1 327 ? 119.610 136.166 154.219 1.00 97.81  ? 317 PHE A CD1   1 
ATOM   2654 C  CD2   . PHE A 1 327 ? 118.212 134.911 152.751 1.00 104.01 ? 317 PHE A CD2   1 
ATOM   2655 C  CE1   . PHE A 1 327 ? 120.209 136.780 153.135 1.00 98.61  ? 317 PHE A CE1   1 
ATOM   2656 C  CE2   . PHE A 1 327 ? 118.807 135.519 151.661 1.00 105.33 ? 317 PHE A CE2   1 
ATOM   2657 C  CZ    . PHE A 1 327 ? 119.808 136.456 151.853 1.00 109.17 ? 317 PHE A CZ    1 
ATOM   2658 N  N     . VAL A 1 328 ? 119.168 133.267 158.095 1.00 83.63  ? 318 VAL A N     1 
ATOM   2659 C  CA    . VAL A 1 328 ? 118.924 132.962 159.498 1.00 80.29  ? 318 VAL A CA    1 
ATOM   2660 C  C     . VAL A 1 328 ? 118.964 134.247 160.310 1.00 75.17  ? 318 VAL A C     1 
ATOM   2661 O  O     . VAL A 1 328 ? 117.975 134.630 160.945 1.00 75.55  ? 318 VAL A O     1 
ATOM   2662 C  CB    . VAL A 1 328 ? 119.953 131.949 160.032 1.00 78.13  ? 318 VAL A CB    1 
ATOM   2663 C  CG1   . VAL A 1 328 ? 119.672 131.620 161.486 1.00 72.01  ? 318 VAL A CG1   1 
ATOM   2664 C  CG2   . VAL A 1 328 ? 119.954 130.690 159.182 1.00 80.91  ? 318 VAL A CG2   1 
ATOM   2665 N  N     . LYS A 1 329 ? 120.109 134.923 160.286 1.00 72.17  ? 319 LYS A N     1 
ATOM   2666 C  CA    . LYS A 1 329 ? 120.347 136.080 161.131 1.00 61.99  ? 319 LYS A CA    1 
ATOM   2667 C  C     . LYS A 1 329 ? 121.067 137.149 160.329 1.00 57.49  ? 319 LYS A C     1 
ATOM   2668 O  O     . LYS A 1 329 ? 121.657 136.878 159.282 1.00 65.64  ? 319 LYS A O     1 
ATOM   2669 C  CB    . LYS A 1 329 ? 121.179 135.710 162.363 1.00 60.05  ? 319 LYS A CB    1 
ATOM   2670 C  CG    . LYS A 1 329 ? 120.500 134.742 163.312 1.00 63.24  ? 319 LYS A CG    1 
ATOM   2671 C  CD    . LYS A 1 329 ? 121.521 133.930 164.080 1.00 62.61  ? 319 LYS A CD    1 
ATOM   2672 C  CE    . LYS A 1 329 ? 120.946 133.418 165.384 1.00 66.87  ? 319 LYS A CE    1 
ATOM   2673 N  NZ    . LYS A 1 329 ? 121.949 132.655 166.170 1.00 65.79  ? 319 LYS A NZ    1 
ATOM   2674 N  N     . THR A 1 330 ? 120.996 138.376 160.829 1.00 51.91  ? 320 THR A N     1 
ATOM   2675 C  CA    . THR A 1 330 ? 121.834 139.470 160.361 1.00 52.00  ? 320 THR A CA    1 
ATOM   2676 C  C     . THR A 1 330 ? 122.431 140.134 161.588 1.00 56.86  ? 320 THR A C     1 
ATOM   2677 O  O     . THR A 1 330 ? 121.725 140.374 162.573 1.00 56.26  ? 320 THR A O     1 
ATOM   2678 C  CB    . THR A 1 330 ? 121.048 140.486 159.527 1.00 54.64  ? 320 THR A CB    1 
ATOM   2679 O  OG1   . THR A 1 330 ? 120.599 139.870 158.314 1.00 56.04  ? 320 THR A OG1   1 
ATOM   2680 C  CG2   . THR A 1 330 ? 121.924 141.675 159.178 1.00 53.97  ? 320 THR A CG2   1 
ATOM   2681 N  N     . VAL A 1 331 ? 123.729 140.416 161.538 1.00 61.07  ? 321 VAL A N     1 
ATOM   2682 C  CA    . VAL A 1 331 ? 124.451 140.906 162.700 1.00 55.51  ? 321 VAL A CA    1 
ATOM   2683 C  C     . VAL A 1 331 ? 125.237 142.148 162.303 1.00 54.52  ? 321 VAL A C     1 
ATOM   2684 O  O     . VAL A 1 331 ? 125.654 142.310 161.156 1.00 59.52  ? 321 VAL A O     1 
ATOM   2685 C  CB    . VAL A 1 331 ? 125.385 139.822 163.283 1.00 49.32  ? 321 VAL A CB    1 
ATOM   2686 C  CG1   . VAL A 1 331 ? 126.505 139.497 162.315 1.00 51.99  ? 321 VAL A CG1   1 
ATOM   2687 C  CG2   . VAL A 1 331 ? 125.915 140.234 164.617 1.00 46.15  ? 321 VAL A CG2   1 
ATOM   2688 N  N     . GLY A 1 332 ? 125.422 143.038 163.273 1.00 52.51  ? 322 GLY A N     1 
ATOM   2689 C  CA    . GLY A 1 332 ? 126.159 144.270 163.074 1.00 50.44  ? 322 GLY A CA    1 
ATOM   2690 C  C     . GLY A 1 332 ? 127.507 144.213 163.774 1.00 51.25  ? 322 GLY A C     1 
ATOM   2691 O  O     . GLY A 1 332 ? 127.589 143.880 164.956 1.00 49.52  ? 322 GLY A O     1 
ATOM   2692 N  N     . LEU A 1 333 ? 128.552 144.534 163.021 1.00 54.10  ? 323 LEU A N     1 
ATOM   2693 C  CA    . LEU A 1 333 ? 129.905 144.646 163.542 1.00 48.29  ? 323 LEU A CA    1 
ATOM   2694 C  C     . LEU A 1 333 ? 130.301 146.113 163.574 1.00 61.69  ? 323 LEU A C     1 
ATOM   2695 O  O     . LEU A 1 333 ? 130.155 146.822 162.573 1.00 68.75  ? 323 LEU A O     1 
ATOM   2696 C  CB    . LEU A 1 333 ? 130.895 143.856 162.687 1.00 51.45  ? 323 LEU A CB    1 
ATOM   2697 C  CG    . LEU A 1 333 ? 131.320 142.464 163.152 1.00 54.95  ? 323 LEU A CG    1 
ATOM   2698 C  CD1   . LEU A 1 333 ? 132.486 141.981 162.313 1.00 54.95  ? 323 LEU A CD1   1 
ATOM   2699 C  CD2   . LEU A 1 333 ? 131.689 142.464 164.620 1.00 44.59  ? 323 LEU A CD2   1 
ATOM   2700 N  N     . ASP A 1 334 ? 130.808 146.560 164.716 1.00 63.49  ? 324 ASP A N     1 
ATOM   2701 C  CA    . ASP A 1 334 ? 131.228 147.937 164.906 1.00 61.61  ? 324 ASP A CA    1 
ATOM   2702 C  C     . ASP A 1 334 ? 132.732 147.975 165.126 1.00 59.86  ? 324 ASP A C     1 
ATOM   2703 O  O     . ASP A 1 334 ? 133.318 147.038 165.674 1.00 58.04  ? 324 ASP A O     1 
ATOM   2704 C  CB    . ASP A 1 334 ? 130.502 148.570 166.098 1.00 62.94  ? 324 ASP A CB    1 
ATOM   2705 C  CG    . ASP A 1 334 ? 130.631 150.076 166.130 1.00 77.86  ? 324 ASP A CG    1 
ATOM   2706 O  OD1   . ASP A 1 334 ? 131.171 150.653 165.164 1.00 80.04  ? 324 ASP A OD1   1 
ATOM   2707 O  OD2   . ASP A 1 334 ? 130.186 150.687 167.124 1.00 83.35  ? 324 ASP A OD2   1 
ATOM   2708 N  N     . VAL A 1 335 ? 133.354 149.052 164.687 1.00 61.10  ? 325 VAL A N     1 
ATOM   2709 C  CA    . VAL A 1 335 ? 134.782 149.253 164.892 1.00 58.08  ? 325 VAL A CA    1 
ATOM   2710 C  C     . VAL A 1 335 ? 134.976 150.181 166.079 1.00 62.72  ? 325 VAL A C     1 
ATOM   2711 O  O     . VAL A 1 335 ? 134.327 151.228 166.184 1.00 66.55  ? 325 VAL A O     1 
ATOM   2712 C  CB    . VAL A 1 335 ? 135.451 149.817 163.626 1.00 63.97  ? 325 VAL A CB    1 
ATOM   2713 C  CG1   . VAL A 1 335 ? 136.913 150.114 163.892 1.00 58.10  ? 325 VAL A CG1   1 
ATOM   2714 C  CG2   . VAL A 1 335 ? 135.313 148.840 162.474 1.00 60.88  ? 325 VAL A CG2   1 
ATOM   2715 N  N     . ASN A 1 336 ? 135.867 149.792 166.985 1.00 60.46  ? 326 ASN A N     1 
ATOM   2716 C  CA    . ASN A 1 336 ? 136.176 150.603 168.149 1.00 56.89  ? 326 ASN A CA    1 
ATOM   2717 C  C     . ASN A 1 336 ? 137.688 150.677 168.293 1.00 54.95  ? 326 ASN A C     1 
ATOM   2718 O  O     . ASN A 1 336 ? 138.431 149.937 167.645 1.00 52.90  ? 326 ASN A O     1 
ATOM   2719 C  CB    . ASN A 1 336 ? 135.515 150.039 169.414 1.00 57.75  ? 326 ASN A CB    1 
ATOM   2720 C  CG    . ASN A 1 336 ? 135.674 150.952 170.619 1.00 60.55  ? 326 ASN A CG    1 
ATOM   2721 O  OD1   . ASN A 1 336 ? 136.007 152.129 170.481 1.00 56.48  ? 326 ASN A OD1   1 
ATOM   2722 N  ND2   . ASN A 1 336 ? 135.436 150.409 171.808 1.00 58.63  ? 326 ASN A ND2   1 
ATOM   2723 N  N     . PHE A 1 337 ? 138.139 151.603 169.133 1.00 57.06  ? 327 PHE A N     1 
ATOM   2724 C  CA    . PHE A 1 337 ? 139.558 151.844 169.324 1.00 53.93  ? 327 PHE A CA    1 
ATOM   2725 C  C     . PHE A 1 337 ? 139.954 151.946 170.787 1.00 51.18  ? 327 PHE A C     1 
ATOM   2726 O  O     . PHE A 1 337 ? 141.144 152.108 171.077 1.00 50.42  ? 327 PHE A O     1 
ATOM   2727 C  CB    . PHE A 1 337 ? 139.975 153.129 168.598 1.00 57.92  ? 327 PHE A CB    1 
ATOM   2728 C  CG    . PHE A 1 337 ? 139.321 153.305 167.261 1.00 65.40  ? 327 PHE A CG    1 
ATOM   2729 C  CD1   . PHE A 1 337 ? 139.851 152.702 166.132 1.00 69.37  ? 327 PHE A CD1   1 
ATOM   2730 C  CD2   . PHE A 1 337 ? 138.167 154.058 167.133 1.00 64.03  ? 327 PHE A CD2   1 
ATOM   2731 C  CE1   . PHE A 1 337 ? 139.249 152.858 164.898 1.00 73.47  ? 327 PHE A CE1   1 
ATOM   2732 C  CE2   . PHE A 1 337 ? 137.560 154.214 165.904 1.00 72.28  ? 327 PHE A CE2   1 
ATOM   2733 C  CZ    . PHE A 1 337 ? 138.100 153.615 164.786 1.00 74.76  ? 327 PHE A CZ    1 
ATOM   2734 N  N     . LYS A 1 338 ? 139.002 151.847 171.713 1.00 45.38  ? 328 LYS A N     1 
ATOM   2735 C  CA    . LYS A 1 338 ? 139.263 152.062 173.128 1.00 46.48  ? 328 LYS A CA    1 
ATOM   2736 C  C     . LYS A 1 338 ? 139.588 150.775 173.876 1.00 47.33  ? 328 LYS A C     1 
ATOM   2737 O  O     . LYS A 1 338 ? 140.611 150.702 174.560 1.00 51.17  ? 328 LYS A O     1 
ATOM   2738 C  CB    . LYS A 1 338 ? 138.065 152.756 173.782 1.00 44.95  ? 328 LYS A CB    1 
ATOM   2739 C  CG    . LYS A 1 338 ? 138.359 153.282 175.172 1.00 48.44  ? 328 LYS A CG    1 
ATOM   2740 C  CD    . LYS A 1 338 ? 137.400 154.381 175.578 1.00 53.18  ? 328 LYS A CD    1 
ATOM   2741 C  CE    . LYS A 1 338 ? 137.768 154.930 176.942 1.00 49.72  ? 328 LYS A CE    1 
ATOM   2742 N  NZ    . LYS A 1 338 ? 139.234 155.153 177.057 1.00 49.88  ? 328 LYS A NZ    1 
ATOM   2743 N  N     . HIS A 1 339 ? 138.741 149.762 173.771 1.00 46.18  ? 329 HIS A N     1 
ATOM   2744 C  CA    . HIS A 1 339 ? 138.957 148.524 174.507 1.00 39.06  ? 329 HIS A CA    1 
ATOM   2745 C  C     . HIS A 1 339 ? 139.070 147.298 173.620 1.00 36.78  ? 329 HIS A C     1 
ATOM   2746 O  O     . HIS A 1 339 ? 139.944 146.464 173.848 1.00 45.99  ? 329 HIS A O     1 
ATOM   2747 C  CB    . HIS A 1 339 ? 137.827 148.321 175.519 1.00 41.53  ? 329 HIS A CB    1 
ATOM   2748 C  CG    . HIS A 1 339 ? 137.781 149.374 176.580 1.00 47.40  ? 329 HIS A CG    1 
ATOM   2749 N  ND1   . HIS A 1 339 ? 138.561 149.322 177.715 1.00 54.83  ? 329 HIS A ND1   1 
ATOM   2750 C  CD2   . HIS A 1 339 ? 137.058 150.514 176.673 1.00 46.29  ? 329 HIS A CD2   1 
ATOM   2751 C  CE1   . HIS A 1 339 ? 138.319 150.384 178.462 1.00 53.01  ? 329 HIS A CE1   1 
ATOM   2752 N  NE2   . HIS A 1 339 ? 137.410 151.123 177.852 1.00 56.08  ? 329 HIS A NE2   1 
ATOM   2753 N  N     . ALA A 1 340 ? 138.209 147.161 172.617 1.00 39.80  ? 330 ALA A N     1 
ATOM   2754 C  CA    . ALA A 1 340 ? 138.255 146.035 171.696 1.00 40.14  ? 330 ALA A CA    1 
ATOM   2755 C  C     . ALA A 1 340 ? 137.940 146.538 170.299 1.00 43.26  ? 330 ALA A C     1 
ATOM   2756 O  O     . ALA A 1 340 ? 137.066 147.390 170.128 1.00 47.62  ? 330 ALA A O     1 
ATOM   2757 C  CB    . ALA A 1 340 ? 137.267 144.936 172.099 1.00 37.23  ? 330 ALA A CB    1 
ATOM   2758 N  N     . PHE A 1 341 ? 138.660 146.021 169.303 1.00 36.92  ? 331 PHE A N     1 
ATOM   2759 C  CA    . PHE A 1 341 ? 138.457 146.488 167.935 1.00 43.58  ? 331 PHE A CA    1 
ATOM   2760 C  C     . PHE A 1 341 ? 137.050 146.191 167.441 1.00 42.17  ? 331 PHE A C     1 
ATOM   2761 O  O     . PHE A 1 341 ? 136.374 147.073 166.902 1.00 46.63  ? 331 PHE A O     1 
ATOM   2762 C  CB    . PHE A 1 341 ? 139.485 145.864 166.995 1.00 40.30  ? 331 PHE A CB    1 
ATOM   2763 C  CG    . PHE A 1 341 ? 140.866 146.394 167.169 1.00 40.45  ? 331 PHE A CG    1 
ATOM   2764 C  CD1   . PHE A 1 341 ? 141.089 147.557 167.876 1.00 40.42  ? 331 PHE A CD1   1 
ATOM   2765 C  CD2   . PHE A 1 341 ? 141.941 145.746 166.595 1.00 39.10  ? 331 PHE A CD2   1 
ATOM   2766 C  CE1   . PHE A 1 341 ? 142.359 148.052 168.023 1.00 38.23  ? 331 PHE A CE1   1 
ATOM   2767 C  CE2   . PHE A 1 341 ? 143.213 146.237 166.738 1.00 35.95  ? 331 PHE A CE2   1 
ATOM   2768 C  CZ    . PHE A 1 341 ? 143.421 147.391 167.448 1.00 36.84  ? 331 PHE A CZ    1 
ATOM   2769 N  N     . PHE A 1 342 ? 136.589 144.959 167.606 1.00 37.55  ? 332 PHE A N     1 
ATOM   2770 C  CA    . PHE A 1 342 ? 135.348 144.517 166.989 1.00 36.65  ? 332 PHE A CA    1 
ATOM   2771 C  C     . PHE A 1 342 ? 134.312 144.266 168.070 1.00 36.80  ? 332 PHE A C     1 
ATOM   2772 O  O     . PHE A 1 342 ? 134.521 143.433 168.956 1.00 36.25  ? 332 PHE A O     1 
ATOM   2773 C  CB    . PHE A 1 342 ? 135.588 143.276 166.133 1.00 31.28  ? 332 PHE A CB    1 
ATOM   2774 C  CG    . PHE A 1 342 ? 136.658 143.472 165.106 1.00 31.37  ? 332 PHE A CG    1 
ATOM   2775 C  CD1   . PHE A 1 342 ? 136.364 144.043 163.886 1.00 32.16  ? 332 PHE A CD1   1 
ATOM   2776 C  CD2   . PHE A 1 342 ? 137.964 143.116 165.371 1.00 33.08  ? 332 PHE A CD2   1 
ATOM   2777 C  CE1   . PHE A 1 342 ? 137.346 144.236 162.948 1.00 33.14  ? 332 PHE A CE1   1 
ATOM   2778 C  CE2   . PHE A 1 342 ? 138.946 143.308 164.432 1.00 33.42  ? 332 PHE A CE2   1 
ATOM   2779 C  CZ    . PHE A 1 342 ? 138.636 143.868 163.221 1.00 30.95  ? 332 PHE A CZ    1 
ATOM   2780 N  N     . VAL A 1 343 ? 133.209 145.001 168.000 1.00 41.62  ? 333 VAL A N     1 
ATOM   2781 C  CA    . VAL A 1 343 ? 132.120 144.902 168.958 1.00 37.35  ? 333 VAL A CA    1 
ATOM   2782 C  C     . VAL A 1 343 ? 130.855 144.552 168.190 1.00 42.77  ? 333 VAL A C     1 
ATOM   2783 O  O     . VAL A 1 343 ? 130.521 145.205 167.195 1.00 45.37  ? 333 VAL A O     1 
ATOM   2784 C  CB    . VAL A 1 343 ? 131.943 146.201 169.757 1.00 36.30  ? 333 VAL A CB    1 
ATOM   2785 C  CG1   . VAL A 1 343 ? 130.819 146.047 170.756 1.00 40.98  ? 333 VAL A CG1   1 
ATOM   2786 C  CG2   . VAL A 1 343 ? 133.233 146.560 170.470 1.00 39.43  ? 333 VAL A CG2   1 
ATOM   2787 N  N     . THR A 1 344 ? 130.167 143.515 168.645 1.00 44.20  ? 334 THR A N     1 
ATOM   2788 C  CA    . THR A 1 344 ? 128.940 143.036 168.037 1.00 47.02  ? 334 THR A CA    1 
ATOM   2789 C  C     . THR A 1 344 ? 127.752 143.572 168.837 1.00 54.27  ? 334 THR A C     1 
ATOM   2790 O  O     . THR A 1 344 ? 127.907 144.120 169.929 1.00 51.20  ? 334 THR A O     1 
ATOM   2791 C  CB    . THR A 1 344 ? 128.987 141.506 167.968 1.00 45.55  ? 334 THR A CB    1 
ATOM   2792 O  OG1   . THR A 1 344 ? 130.109 141.103 167.177 1.00 47.95  ? 334 THR A OG1   1 
ATOM   2793 C  CG2   . THR A 1 344 ? 127.753 140.913 167.370 1.00 48.46  ? 334 THR A CG2   1 
ATOM   2794 N  N     . SER A 1 345 ? 126.552 143.453 168.280 1.00 57.15  ? 335 SER A N     1 
ATOM   2795 C  CA    . SER A 1 345 ? 125.338 143.803 168.995 1.00 57.88  ? 335 SER A CA    1 
ATOM   2796 C  C     . SER A 1 345 ? 124.721 142.612 169.711 1.00 58.72  ? 335 SER A C     1 
ATOM   2797 O  O     . SER A 1 345 ? 123.734 142.781 170.430 1.00 65.81  ? 335 SER A O     1 
ATOM   2798 C  CB    . SER A 1 345 ? 124.322 144.420 168.029 1.00 61.56  ? 335 SER A CB    1 
ATOM   2799 O  OG    . SER A 1 345 ? 123.892 143.469 167.071 1.00 58.36  ? 335 SER A OG    1 
ATOM   2800 N  N     . GLU A 1 346 ? 125.281 141.419 169.539 1.00 57.04  ? 336 GLU A N     1 
ATOM   2801 C  CA    . GLU A 1 346 ? 124.740 140.234 170.183 1.00 59.48  ? 336 GLU A CA    1 
ATOM   2802 C  C     . GLU A 1 346 ? 125.074 140.222 171.670 1.00 55.57  ? 336 GLU A C     1 
ATOM   2803 O  O     . GLU A 1 346 ? 126.021 140.861 172.132 1.00 53.48  ? 336 GLU A O     1 
ATOM   2804 C  CB    . GLU A 1 346 ? 125.283 138.962 169.530 1.00 55.20  ? 336 GLU A CB    1 
ATOM   2805 C  CG    . GLU A 1 346 ? 124.909 138.801 168.074 1.00 57.23  ? 336 GLU A CG    1 
ATOM   2806 C  CD    . GLU A 1 346 ? 123.414 138.702 167.868 1.00 69.82  ? 336 GLU A CD    1 
ATOM   2807 O  OE1   . GLU A 1 346 ? 122.783 137.809 168.474 1.00 72.78  ? 336 GLU A OE1   1 
ATOM   2808 O  OE2   . GLU A 1 346 ? 122.868 139.525 167.104 1.00 74.43  ? 336 GLU A OE2   1 
ATOM   2809 N  N     . LYS A 1 347 ? 124.268 139.484 172.421 1.00 57.20  ? 337 LYS A N     1 
ATOM   2810 C  CA    . LYS A 1 347 ? 124.554 139.178 173.814 1.00 55.97  ? 337 LYS A CA    1 
ATOM   2811 C  C     . LYS A 1 347 ? 125.172 137.788 173.871 1.00 56.65  ? 337 LYS A C     1 
ATOM   2812 O  O     . LYS A 1 347 ? 124.559 136.816 173.419 1.00 56.68  ? 337 LYS A O     1 
ATOM   2813 C  CB    . LYS A 1 347 ? 123.289 139.241 174.668 1.00 55.87  ? 337 LYS A CB    1 
ATOM   2814 C  CG    . LYS A 1 347 ? 122.627 140.606 174.697 1.00 62.05  ? 337 LYS A CG    1 
ATOM   2815 C  CD    . LYS A 1 347 ? 123.580 141.664 175.219 1.00 62.99  ? 337 LYS A CD    1 
ATOM   2816 C  CE    . LYS A 1 347 ? 122.977 143.052 175.121 1.00 60.40  ? 337 LYS A CE    1 
ATOM   2817 N  NZ    . LYS A 1 347 ? 123.901 144.076 175.669 1.00 61.49  ? 337 LYS A NZ    1 
ATOM   2818 N  N     . ASP A 1 348 ? 126.384 137.698 174.411 1.00 55.36  ? 338 ASP A N     1 
ATOM   2819 C  CA    . ASP A 1 348 ? 127.047 136.408 174.534 1.00 60.42  ? 338 ASP A CA    1 
ATOM   2820 C  C     . ASP A 1 348 ? 126.253 135.493 175.456 1.00 59.05  ? 338 ASP A C     1 
ATOM   2821 O  O     . ASP A 1 348 ? 126.183 135.728 176.666 1.00 59.20  ? 338 ASP A O     1 
ATOM   2822 C  CB    . ASP A 1 348 ? 128.475 136.587 175.051 1.00 53.82  ? 338 ASP A CB    1 
ATOM   2823 C  CG    . ASP A 1 348 ? 129.281 135.310 174.991 1.00 53.86  ? 338 ASP A CG    1 
ATOM   2824 O  OD1   . ASP A 1 348 ? 128.900 134.401 174.228 1.00 54.04  ? 338 ASP A OD1   1 
ATOM   2825 O  OD2   . ASP A 1 348 ? 130.298 135.215 175.705 1.00 50.99  ? 338 ASP A OD2   1 
ATOM   2826 N  N     . ASN A 1 349 ? 125.642 134.454 174.891 1.00 53.24  ? 339 ASN A N     1 
ATOM   2827 C  CA    . ASN A 1 349 ? 124.895 133.467 175.660 1.00 60.16  ? 339 ASN A CA    1 
ATOM   2828 C  C     . ASN A 1 349 ? 125.451 132.063 175.461 1.00 62.88  ? 339 ASN A C     1 
ATOM   2829 O  O     . ASN A 1 349 ? 124.727 131.080 175.655 1.00 57.42  ? 339 ASN A O     1 
ATOM   2830 C  CB    . ASN A 1 349 ? 123.410 133.502 175.289 1.00 62.13  ? 339 ASN A CB    1 
ATOM   2831 C  CG    . ASN A 1 349 ? 122.646 134.568 176.040 1.00 64.78  ? 339 ASN A CG    1 
ATOM   2832 O  OD1   . ASN A 1 349 ? 123.162 135.176 176.974 1.00 64.03  ? 339 ASN A OD1   1 
ATOM   2833 N  ND2   . ASN A 1 349 ? 121.407 134.807 175.628 1.00 59.41  ? 339 ASN A ND2   1 
ATOM   2834 N  N     . CYS A 1 350 ? 126.717 131.956 175.066 1.00 62.96  ? 340 CYS A N     1 
ATOM   2835 C  CA    . CYS A 1 350 ? 127.364 130.708 174.679 1.00 56.38  ? 340 CYS A CA    1 
ATOM   2836 C  C     . CYS A 1 350 ? 126.708 130.070 173.462 1.00 55.25  ? 340 CYS A C     1 
ATOM   2837 O  O     . CYS A 1 350 ? 126.985 128.906 173.153 1.00 58.23  ? 340 CYS A O     1 
ATOM   2838 C  CB    . CYS A 1 350 ? 127.405 129.708 175.841 1.00 58.04  ? 340 CYS A CB    1 
ATOM   2839 S  SG    . CYS A 1 350 ? 128.435 130.230 177.232 1.00 71.79  ? 340 CYS A SG    1 
ATOM   2840 N  N     . HIS A 1 351 ? 125.845 130.809 172.760 1.00 50.39  ? 341 HIS A N     1 
ATOM   2841 C  CA    . HIS A 1 351 ? 125.192 130.271 171.573 1.00 46.62  ? 341 HIS A CA    1 
ATOM   2842 C  C     . HIS A 1 351 ? 126.191 130.037 170.449 1.00 47.78  ? 341 HIS A C     1 
ATOM   2843 O  O     . HIS A 1 351 ? 126.084 129.050 169.714 1.00 50.97  ? 341 HIS A O     1 
ATOM   2844 C  CB    . HIS A 1 351 ? 124.070 131.207 171.116 1.00 51.68  ? 341 HIS A CB    1 
ATOM   2845 C  CG    . HIS A 1 351 ? 124.537 132.568 170.694 1.00 54.64  ? 341 HIS A CG    1 
ATOM   2846 N  ND1   . HIS A 1 351 ? 125.285 133.389 171.509 1.00 56.93  ? 341 HIS A ND1   1 
ATOM   2847 C  CD2   . HIS A 1 351 ? 124.345 133.257 169.544 1.00 49.03  ? 341 HIS A CD2   1 
ATOM   2848 C  CE1   . HIS A 1 351 ? 125.540 134.521 170.877 1.00 50.57  ? 341 HIS A CE1   1 
ATOM   2849 N  NE2   . HIS A 1 351 ? 124.981 134.465 169.683 1.00 45.94  ? 341 HIS A NE2   1 
ATOM   2850 N  N     . LEU A 1 352 ? 127.163 130.930 170.298 1.00 48.10  ? 342 LEU A N     1 
ATOM   2851 C  CA    . LEU A 1 352 ? 128.164 130.775 169.254 1.00 46.01  ? 342 LEU A CA    1 
ATOM   2852 C  C     . LEU A 1 352 ? 129.103 129.620 169.577 1.00 42.96  ? 342 LEU A C     1 
ATOM   2853 O  O     . LEU A 1 352 ? 129.570 129.474 170.708 1.00 45.81  ? 342 LEU A O     1 
ATOM   2854 C  CB    . LEU A 1 352 ? 128.962 132.067 169.085 1.00 46.74  ? 342 LEU A CB    1 
ATOM   2855 C  CG    . LEU A 1 352 ? 128.186 133.313 168.656 1.00 42.11  ? 342 LEU A CG    1 
ATOM   2856 C  CD1   . LEU A 1 352 ? 129.116 134.490 168.476 1.00 35.05  ? 342 LEU A CD1   1 
ATOM   2857 C  CD2   . LEU A 1 352 ? 127.423 133.049 167.383 1.00 42.45  ? 342 LEU A CD2   1 
ATOM   2858 N  N     . ASP A 1 353 ? 129.376 128.796 168.573 1.00 43.43  ? 343 ASP A N     1 
ATOM   2859 C  CA    . ASP A 1 353 ? 130.326 127.700 168.686 1.00 42.01  ? 343 ASP A CA    1 
ATOM   2860 C  C     . ASP A 1 353 ? 131.676 128.146 168.148 1.00 41.63  ? 343 ASP A C     1 
ATOM   2861 O  O     . ASP A 1 353 ? 131.756 128.773 167.089 1.00 44.06  ? 343 ASP A O     1 
ATOM   2862 C  CB    . ASP A 1 353 ? 129.844 126.469 167.917 1.00 45.81  ? 343 ASP A CB    1 
ATOM   2863 C  CG    . ASP A 1 353 ? 128.569 125.883 168.490 1.00 58.84  ? 343 ASP A CG    1 
ATOM   2864 O  OD1   . ASP A 1 353 ? 128.272 126.139 169.675 1.00 58.22  ? 343 ASP A OD1   1 
ATOM   2865 O  OD2   . ASP A 1 353 ? 127.861 125.167 167.753 1.00 56.62  ? 343 ASP A OD2   1 
ATOM   2866 N  N     . GLY A 1 354 ? 132.734 127.824 168.881 1.00 34.27  ? 344 GLY A N     1 
ATOM   2867 C  CA    . GLY A 1 354 ? 134.059 128.235 168.483 1.00 26.76  ? 344 GLY A CA    1 
ATOM   2868 C  C     . GLY A 1 354 ? 134.416 129.655 168.840 1.00 34.74  ? 344 GLY A C     1 
ATOM   2869 O  O     . GLY A 1 354 ? 135.452 130.148 168.386 1.00 39.58  ? 344 GLY A O     1 
ATOM   2870 N  N     . TYR A 1 355 ? 133.593 130.330 169.634 1.00 34.50  ? 345 TYR A N     1 
ATOM   2871 C  CA    . TYR A 1 355 ? 133.858 131.692 170.071 1.00 30.63  ? 345 TYR A CA    1 
ATOM   2872 C  C     . TYR A 1 355 ? 134.445 131.662 171.473 1.00 29.09  ? 345 TYR A C     1 
ATOM   2873 O  O     . TYR A 1 355 ? 133.859 131.063 172.379 1.00 34.08  ? 345 TYR A O     1 
ATOM   2874 C  CB    . TYR A 1 355 ? 132.577 132.528 170.059 1.00 36.29  ? 345 TYR A CB    1 
ATOM   2875 C  CG    . TYR A 1 355 ? 132.756 133.941 170.567 1.00 33.14  ? 345 TYR A CG    1 
ATOM   2876 C  CD1   . TYR A 1 355 ? 133.689 134.789 169.993 1.00 28.57  ? 345 TYR A CD1   1 
ATOM   2877 C  CD2   . TYR A 1 355 ? 131.994 134.426 171.621 1.00 31.23  ? 345 TYR A CD2   1 
ATOM   2878 C  CE1   . TYR A 1 355 ? 133.858 136.072 170.451 1.00 26.73  ? 345 TYR A CE1   1 
ATOM   2879 C  CE2   . TYR A 1 355 ? 132.160 135.715 172.085 1.00 30.41  ? 345 TYR A CE2   1 
ATOM   2880 C  CZ    . TYR A 1 355 ? 133.095 136.531 171.493 1.00 26.96  ? 345 TYR A CZ    1 
ATOM   2881 O  OH    . TYR A 1 355 ? 133.280 137.818 171.935 1.00 27.26  ? 345 TYR A OH    1 
ATOM   2882 N  N     . ILE A 1 356 ? 135.596 132.301 171.648 1.00 27.73  ? 346 ILE A N     1 
ATOM   2883 C  CA    . ILE A 1 356 ? 136.196 132.479 172.964 1.00 29.51  ? 346 ILE A CA    1 
ATOM   2884 C  C     . ILE A 1 356 ? 136.034 133.944 173.353 1.00 31.62  ? 346 ILE A C     1 
ATOM   2885 O  O     . ILE A 1 356 ? 136.470 134.848 172.629 1.00 30.85  ? 346 ILE A O     1 
ATOM   2886 C  CB    . ILE A 1 356 ? 137.666 132.017 173.000 1.00 30.92  ? 346 ILE A CB    1 
ATOM   2887 C  CG1   . ILE A 1 356 ? 138.206 132.061 174.429 1.00 29.40  ? 346 ILE A CG1   1 
ATOM   2888 C  CG2   . ILE A 1 356 ? 138.557 132.812 172.054 1.00 28.02  ? 346 ILE A CG2   1 
ATOM   2889 C  CD1   . ILE A 1 356 ? 137.425 131.208 175.395 1.00 32.49  ? 346 ILE A CD1   1 
ATOM   2890 N  N     . ASN A 1 357 ? 135.361 134.176 174.476 1.00 30.67  ? 347 ASN A N     1 
ATOM   2891 C  CA    . ASN A 1 357 ? 135.102 135.519 174.985 1.00 27.80  ? 347 ASN A CA    1 
ATOM   2892 C  C     . ASN A 1 357 ? 136.246 135.880 175.919 1.00 31.14  ? 347 ASN A C     1 
ATOM   2893 O  O     . ASN A 1 357 ? 136.280 135.449 177.071 1.00 37.51  ? 347 ASN A O     1 
ATOM   2894 C  CB    . ASN A 1 357 ? 133.756 135.567 175.697 1.00 32.88  ? 347 ASN A CB    1 
ATOM   2895 C  CG    . ASN A 1 357 ? 133.267 136.977 175.934 1.00 37.81  ? 347 ASN A CG    1 
ATOM   2896 O  OD1   . ASN A 1 357 ? 133.980 137.949 175.687 1.00 38.80  ? 347 ASN A OD1   1 
ATOM   2897 N  ND2   . ASN A 1 357 ? 132.037 137.097 176.413 1.00 36.57  ? 347 ASN A ND2   1 
ATOM   2898 N  N     . LEU A 1 358 ? 137.193 136.671 175.421 1.00 32.26  ? 348 LEU A N     1 
ATOM   2899 C  CA    . LEU A 1 358 ? 138.401 136.937 176.185 1.00 30.84  ? 348 LEU A CA    1 
ATOM   2900 C  C     . LEU A 1 358 ? 138.176 137.916 177.328 1.00 34.86  ? 348 LEU A C     1 
ATOM   2901 O  O     . LEU A 1 358 ? 138.861 137.816 178.350 1.00 39.40  ? 348 LEU A O     1 
ATOM   2902 C  CB    . LEU A 1 358 ? 139.505 137.451 175.262 1.00 28.27  ? 348 LEU A CB    1 
ATOM   2903 C  CG    . LEU A 1 358 ? 139.888 136.506 174.123 1.00 24.12  ? 348 LEU A CG    1 
ATOM   2904 C  CD1   . LEU A 1 358 ? 141.115 136.980 173.387 1.00 22.11  ? 348 LEU A CD1   1 
ATOM   2905 C  CD2   . LEU A 1 358 ? 140.094 135.119 174.636 1.00 22.83  ? 348 LEU A CD2   1 
ATOM   2906 N  N     . TYR A 1 359 ? 137.238 138.852 177.190 1.00 36.64  ? 349 TYR A N     1 
ATOM   2907 C  CA    . TYR A 1 359 ? 136.927 139.738 178.306 1.00 31.29  ? 349 TYR A CA    1 
ATOM   2908 C  C     . TYR A 1 359 ? 136.246 138.984 179.437 1.00 33.67  ? 349 TYR A C     1 
ATOM   2909 O  O     . TYR A 1 359 ? 136.530 139.234 180.610 1.00 42.09  ? 349 TYR A O     1 
ATOM   2910 C  CB    . TYR A 1 359 ? 136.053 140.897 177.838 1.00 29.94  ? 349 TYR A CB    1 
ATOM   2911 C  CG    . TYR A 1 359 ? 136.858 142.060 177.337 1.00 30.40  ? 349 TYR A CG    1 
ATOM   2912 C  CD1   . TYR A 1 359 ? 137.676 142.772 178.186 1.00 29.94  ? 349 TYR A CD1   1 
ATOM   2913 C  CD2   . TYR A 1 359 ? 136.811 142.436 176.009 1.00 36.37  ? 349 TYR A CD2   1 
ATOM   2914 C  CE1   . TYR A 1 359 ? 138.419 143.825 177.729 1.00 35.68  ? 349 TYR A CE1   1 
ATOM   2915 C  CE2   . TYR A 1 359 ? 137.553 143.492 175.545 1.00 33.69  ? 349 TYR A CE2   1 
ATOM   2916 C  CZ    . TYR A 1 359 ? 138.354 144.182 176.410 1.00 34.79  ? 349 TYR A CZ    1 
ATOM   2917 O  OH    . TYR A 1 359 ? 139.097 145.241 175.957 1.00 38.41  ? 349 TYR A OH    1 
ATOM   2918 N  N     . LYS A 1 360 ? 135.346 138.061 179.104 1.00 36.86  ? 350 LYS A N     1 
ATOM   2919 C  CA    . LYS A 1 360 ? 134.727 137.235 180.131 1.00 40.12  ? 350 LYS A CA    1 
ATOM   2920 C  C     . LYS A 1 360 ? 135.744 136.305 180.780 1.00 45.37  ? 350 LYS A C     1 
ATOM   2921 O  O     . LYS A 1 360 ? 135.602 135.953 181.955 1.00 45.90  ? 350 LYS A O     1 
ATOM   2922 C  CB    . LYS A 1 360 ? 133.561 136.452 179.526 1.00 38.22  ? 350 LYS A CB    1 
ATOM   2923 C  CG    . LYS A 1 360 ? 133.015 135.341 180.393 1.00 39.52  ? 350 LYS A CG    1 
ATOM   2924 C  CD    . LYS A 1 360 ? 131.878 134.616 179.704 1.00 42.61  ? 350 LYS A CD    1 
ATOM   2925 C  CE    . LYS A 1 360 ? 130.713 135.550 179.446 1.00 46.90  ? 350 LYS A CE    1 
ATOM   2926 N  NZ    . LYS A 1 360 ? 129.530 134.836 178.899 1.00 48.80  ? 350 LYS A NZ    1 
ATOM   2927 N  N     . TYR A 1 361 ? 136.782 135.913 180.042 1.00 40.07  ? 351 TYR A N     1 
ATOM   2928 C  CA    . TYR A 1 361 ? 137.840 135.089 180.612 1.00 36.14  ? 351 TYR A CA    1 
ATOM   2929 C  C     . TYR A 1 361 ? 138.743 135.900 181.535 1.00 40.77  ? 351 TYR A C     1 
ATOM   2930 O  O     . TYR A 1 361 ? 139.172 135.400 182.579 1.00 49.67  ? 351 TYR A O     1 
ATOM   2931 C  CB    . TYR A 1 361 ? 138.648 134.433 179.488 1.00 34.65  ? 351 TYR A CB    1 
ATOM   2932 C  CG    . TYR A 1 361 ? 140.057 134.023 179.859 1.00 37.00  ? 351 TYR A CG    1 
ATOM   2933 C  CD1   . TYR A 1 361 ? 140.314 132.791 180.439 1.00 34.43  ? 351 TYR A CD1   1 
ATOM   2934 C  CD2   . TYR A 1 361 ? 141.134 134.862 179.607 1.00 38.32  ? 351 TYR A CD2   1 
ATOM   2935 C  CE1   . TYR A 1 361 ? 141.596 132.415 180.770 1.00 31.48  ? 351 TYR A CE1   1 
ATOM   2936 C  CE2   . TYR A 1 361 ? 142.417 134.495 179.940 1.00 32.93  ? 351 TYR A CE2   1 
ATOM   2937 C  CZ    . TYR A 1 361 ? 142.642 133.271 180.519 1.00 33.15  ? 351 TYR A CZ    1 
ATOM   2938 O  OH    . TYR A 1 361 ? 143.924 132.906 180.845 1.00 34.21  ? 351 TYR A OH    1 
ATOM   2939 N  N     . LEU A 1 362 ? 139.044 137.150 181.170 1.00 39.00  ? 352 LEU A N     1 
ATOM   2940 C  CA    . LEU A 1 362 ? 139.892 137.989 182.010 1.00 38.99  ? 352 LEU A CA    1 
ATOM   2941 C  C     . LEU A 1 362 ? 139.214 138.390 183.310 1.00 43.33  ? 352 LEU A C     1 
ATOM   2942 O  O     . LEU A 1 362 ? 139.898 138.827 184.238 1.00 51.15  ? 352 LEU A O     1 
ATOM   2943 C  CB    . LEU A 1 362 ? 140.307 139.252 181.262 1.00 32.24  ? 352 LEU A CB    1 
ATOM   2944 C  CG    . LEU A 1 362 ? 141.255 139.114 180.078 1.00 38.53  ? 352 LEU A CG    1 
ATOM   2945 C  CD1   . LEU A 1 362 ? 141.100 140.316 179.179 1.00 40.29  ? 352 LEU A CD1   1 
ATOM   2946 C  CD2   . LEU A 1 362 ? 142.689 138.968 180.534 1.00 39.46  ? 352 LEU A CD2   1 
ATOM   2947 N  N     . LEU A 1 363 ? 137.892 138.276 183.394 1.00 41.29  ? 353 LEU A N     1 
ATOM   2948 C  CA    . LEU A 1 363 ? 137.163 138.655 184.594 1.00 42.71  ? 353 LEU A CA    1 
ATOM   2949 C  C     . LEU A 1 363 ? 137.026 137.518 185.589 1.00 50.74  ? 353 LEU A C     1 
ATOM   2950 O  O     . LEU A 1 363 ? 136.548 137.748 186.705 1.00 53.89  ? 353 LEU A O     1 
ATOM   2951 C  CB    . LEU A 1 363 ? 135.768 139.168 184.230 1.00 45.58  ? 353 LEU A CB    1 
ATOM   2952 C  CG    . LEU A 1 363 ? 135.692 140.483 183.461 1.00 44.69  ? 353 LEU A CG    1 
ATOM   2953 C  CD1   . LEU A 1 363 ? 134.252 140.945 183.374 1.00 39.05  ? 353 LEU A CD1   1 
ATOM   2954 C  CD2   . LEU A 1 363 ? 136.577 141.544 184.101 1.00 42.91  ? 353 LEU A CD2   1 
ATOM   2955 N  N     . GLU A 1 364 ? 137.419 136.306 185.218 1.00 50.99  ? 354 GLU A N     1 
ATOM   2956 C  CA    . GLU A 1 364 ? 137.383 135.171 186.125 1.00 50.44  ? 354 GLU A CA    1 
ATOM   2957 C  C     . GLU A 1 364 ? 138.680 135.008 186.898 1.00 54.48  ? 354 GLU A C     1 
ATOM   2958 O  O     . GLU A 1 364 ? 138.816 134.045 187.658 1.00 58.98  ? 354 GLU A O     1 
ATOM   2959 C  CB    . GLU A 1 364 ? 137.074 133.888 185.352 1.00 49.83  ? 354 GLU A CB    1 
ATOM   2960 C  CG    . GLU A 1 364 ? 135.774 133.946 184.577 1.00 55.03  ? 354 GLU A CG    1 
ATOM   2961 C  CD    . GLU A 1 364 ? 135.720 132.937 183.451 1.00 65.54  ? 354 GLU A CD    1 
ATOM   2962 O  OE1   . GLU A 1 364 ? 136.679 132.152 183.306 1.00 62.48  ? 354 GLU A OE1   1 
ATOM   2963 O  OE2   . GLU A 1 364 ? 134.716 132.933 182.709 1.00 66.59  ? 354 GLU A OE2   1 
ATOM   2964 N  N     . HIS A 1 365 ? 139.631 135.916 186.714 1.00 52.66  ? 355 HIS A N     1 
ATOM   2965 C  CA    . HIS A 1 365 ? 140.884 135.909 187.453 1.00 53.97  ? 355 HIS A CA    1 
ATOM   2966 C  C     . HIS A 1 365 ? 140.839 137.009 188.502 1.00 59.13  ? 355 HIS A C     1 
ATOM   2967 O  O     . HIS A 1 365 ? 140.630 138.180 188.170 1.00 62.55  ? 355 HIS A O     1 
ATOM   2968 C  CB    . HIS A 1 365 ? 142.073 136.112 186.516 1.00 49.16  ? 355 HIS A CB    1 
ATOM   2969 C  CG    . HIS A 1 365 ? 142.391 134.916 185.676 1.00 46.67  ? 355 HIS A CG    1 
ATOM   2970 N  ND1   . HIS A 1 365 ? 141.824 134.703 184.439 1.00 47.62  ? 355 HIS A ND1   1 
ATOM   2971 C  CD2   . HIS A 1 365 ? 143.222 133.871 185.894 1.00 44.58  ? 355 HIS A CD2   1 
ATOM   2972 C  CE1   . HIS A 1 365 ? 142.287 133.576 183.934 1.00 47.33  ? 355 HIS A CE1   1 
ATOM   2973 N  NE2   . HIS A 1 365 ? 143.140 133.052 184.795 1.00 44.94  ? 355 HIS A NE2   1 
ATOM   2974 N  N     . ASP A 1 366 ? 141.033 136.631 189.767 1.00 59.28  ? 356 ASP A N     1 
ATOM   2975 C  CA    . ASP A 1 366 ? 141.102 137.631 190.824 1.00 62.66  ? 356 ASP A CA    1 
ATOM   2976 C  C     . ASP A 1 366 ? 142.304 138.541 190.643 1.00 60.20  ? 356 ASP A C     1 
ATOM   2977 O  O     . ASP A 1 366 ? 142.240 139.725 190.988 1.00 60.90  ? 356 ASP A O     1 
ATOM   2978 C  CB    . ASP A 1 366 ? 141.153 136.953 192.191 1.00 69.82  ? 356 ASP A CB    1 
ATOM   2979 C  CG    . ASP A 1 366 ? 139.846 136.286 192.556 1.00 78.89  ? 356 ASP A CG    1 
ATOM   2980 O  OD1   . ASP A 1 366 ? 138.929 136.278 191.708 1.00 81.46  ? 356 ASP A OD1   1 
ATOM   2981 O  OD2   . ASP A 1 366 ? 139.735 135.774 193.689 1.00 77.38  ? 356 ASP A OD2   1 
ATOM   2982 N  N     . GLU A 1 367 ? 143.400 138.011 190.096 1.00 59.44  ? 357 GLU A N     1 
ATOM   2983 C  CA    . GLU A 1 367 ? 144.599 138.816 189.895 1.00 58.58  ? 357 GLU A CA    1 
ATOM   2984 C  C     . GLU A 1 367 ? 144.329 140.024 189.010 1.00 59.03  ? 357 GLU A C     1 
ATOM   2985 O  O     . GLU A 1 367 ? 144.924 141.086 189.216 1.00 56.11  ? 357 GLU A O     1 
ATOM   2986 C  CB    . GLU A 1 367 ? 145.710 137.962 189.289 1.00 56.56  ? 357 GLU A CB    1 
ATOM   2987 C  CG    . GLU A 1 367 ? 147.106 138.438 189.636 1.00 55.51  ? 357 GLU A CG    1 
ATOM   2988 C  CD    . GLU A 1 367 ? 148.173 137.436 189.252 1.00 64.41  ? 357 GLU A CD    1 
ATOM   2989 O  OE1   . GLU A 1 367 ? 147.846 136.454 188.552 1.00 63.21  ? 357 GLU A OE1   1 
ATOM   2990 O  OE2   . GLU A 1 367 ? 149.342 137.634 189.642 1.00 61.79  ? 357 GLU A OE2   1 
ATOM   2991 N  N     . PHE A 1 368 ? 143.437 139.887 188.029 1.00 58.95  ? 358 PHE A N     1 
ATOM   2992 C  CA    . PHE A 1 368 ? 143.176 140.990 187.113 1.00 51.92  ? 358 PHE A CA    1 
ATOM   2993 C  C     . PHE A 1 368 ? 142.215 142.009 187.712 1.00 56.52  ? 358 PHE A C     1 
ATOM   2994 O  O     . PHE A 1 368 ? 142.496 143.211 187.706 1.00 59.25  ? 358 PHE A O     1 
ATOM   2995 C  CB    . PHE A 1 368 ? 142.629 140.464 185.788 1.00 46.18  ? 358 PHE A CB    1 
ATOM   2996 C  CG    . PHE A 1 368 ? 142.429 141.534 184.760 1.00 46.98  ? 358 PHE A CG    1 
ATOM   2997 C  CD1   . PHE A 1 368 ? 143.499 142.285 184.312 1.00 44.17  ? 358 PHE A CD1   1 
ATOM   2998 C  CD2   . PHE A 1 368 ? 141.173 141.800 184.253 1.00 47.72  ? 358 PHE A CD2   1 
ATOM   2999 C  CE1   . PHE A 1 368 ? 143.321 143.272 183.375 1.00 42.98  ? 358 PHE A CE1   1 
ATOM   3000 C  CE2   . PHE A 1 368 ? 140.990 142.788 183.316 1.00 46.70  ? 358 PHE A CE2   1 
ATOM   3001 C  CZ    . PHE A 1 368 ? 142.065 143.523 182.875 1.00 45.26  ? 358 PHE A CZ    1 
ATOM   3002 N  N     . THR A 1 369 ? 141.072 141.551 188.227 1.00 58.32  ? 359 THR A N     1 
ATOM   3003 C  CA    . THR A 1 369 ? 140.048 142.484 188.682 1.00 56.58  ? 359 THR A CA    1 
ATOM   3004 C  C     . THR A 1 369 ? 140.408 143.155 190.000 1.00 56.76  ? 359 THR A C     1 
ATOM   3005 O  O     . THR A 1 369 ? 139.836 144.202 190.318 1.00 59.52  ? 359 THR A O     1 
ATOM   3006 C  CB    . THR A 1 369 ? 138.699 141.776 188.811 1.00 58.44  ? 359 THR A CB    1 
ATOM   3007 O  OG1   . THR A 1 369 ? 138.818 140.664 189.704 1.00 68.31  ? 359 THR A OG1   1 
ATOM   3008 C  CG2   . THR A 1 369 ? 138.239 141.279 187.460 1.00 55.46  ? 359 THR A CG2   1 
ATOM   3009 N  N     . ASN A 1 370 ? 141.339 142.588 190.769 1.00 54.98  ? 360 ASN A N     1 
ATOM   3010 C  CA    . ASN A 1 370 ? 141.783 143.248 191.992 1.00 55.51  ? 360 ASN A CA    1 
ATOM   3011 C  C     . ASN A 1 370 ? 142.501 144.560 191.712 1.00 52.44  ? 360 ASN A C     1 
ATOM   3012 O  O     . ASN A 1 370 ? 142.547 145.425 192.590 1.00 51.67  ? 360 ASN A O     1 
ATOM   3013 C  CB    . ASN A 1 370 ? 142.694 142.321 192.796 1.00 60.91  ? 360 ASN A CB    1 
ATOM   3014 C  CG    . ASN A 1 370 ? 141.919 141.290 193.587 1.00 62.97  ? 360 ASN A CG    1 
ATOM   3015 O  OD1   . ASN A 1 370 ? 140.689 141.263 193.556 1.00 52.15  ? 360 ASN A OD1   1 
ATOM   3016 N  ND2   . ASN A 1 370 ? 142.634 140.432 194.301 1.00 65.57  ? 360 ASN A ND2   1 
ATOM   3017 N  N     . LEU A 1 371 ? 143.059 144.725 190.518 1.00 55.57  ? 361 LEU A N     1 
ATOM   3018 C  CA    . LEU A 1 371 ? 143.707 145.965 190.121 1.00 55.51  ? 361 LEU A CA    1 
ATOM   3019 C  C     . LEU A 1 371 ? 142.737 146.968 189.517 1.00 53.75  ? 361 LEU A C     1 
ATOM   3020 O  O     . LEU A 1 371 ? 143.145 148.088 189.197 1.00 51.48  ? 361 LEU A O     1 
ATOM   3021 C  CB    . LEU A 1 371 ? 144.824 145.675 189.116 1.00 54.09  ? 361 LEU A CB    1 
ATOM   3022 C  CG    . LEU A 1 371 ? 145.837 144.599 189.492 1.00 48.35  ? 361 LEU A CG    1 
ATOM   3023 C  CD1   . LEU A 1 371 ? 146.529 144.083 188.252 1.00 45.38  ? 361 LEU A CD1   1 
ATOM   3024 C  CD2   . LEU A 1 371 ? 146.844 145.148 190.480 1.00 44.41  ? 361 LEU A CD2   1 
ATOM   3025 N  N     . LEU A 1 372 ? 141.473 146.597 189.357 1.00 52.49  ? 362 LEU A N     1 
ATOM   3026 C  CA    . LEU A 1 372 ? 140.493 147.416 188.664 1.00 54.57  ? 362 LEU A CA    1 
ATOM   3027 C  C     . LEU A 1 372 ? 139.717 148.282 189.645 1.00 61.03  ? 362 LEU A C     1 
ATOM   3028 O  O     . LEU A 1 372 ? 139.499 147.907 190.800 1.00 64.07  ? 362 LEU A O     1 
ATOM   3029 C  CB    . LEU A 1 372 ? 139.521 146.539 187.874 1.00 57.88  ? 362 LEU A CB    1 
ATOM   3030 C  CG    . LEU A 1 372 ? 140.124 145.671 186.772 1.00 53.99  ? 362 LEU A CG    1 
ATOM   3031 C  CD1   . LEU A 1 372 ? 139.025 145.075 185.923 1.00 48.02  ? 362 LEU A CD1   1 
ATOM   3032 C  CD2   . LEU A 1 372 ? 141.092 146.478 185.923 1.00 56.16  ? 362 LEU A CD2   1 
ATOM   3033 N  N     . THR A 1 373 ? 139.296 149.449 189.169 1.00 65.25  ? 363 THR A N     1 
ATOM   3034 C  CA    . THR A 1 373 ? 138.462 150.341 189.958 1.00 63.61  ? 363 THR A CA    1 
ATOM   3035 C  C     . THR A 1 373 ? 137.004 149.907 189.826 1.00 64.20  ? 363 THR A C     1 
ATOM   3036 O  O     . THR A 1 373 ? 136.694 148.843 189.285 1.00 63.40  ? 363 THR A O     1 
ATOM   3037 C  CB    . THR A 1 373 ? 138.665 151.786 189.518 1.00 63.79  ? 363 THR A CB    1 
ATOM   3038 O  OG1   . THR A 1 373 ? 138.148 151.956 188.193 1.00 65.18  ? 363 THR A OG1   1 
ATOM   3039 C  CG2   . THR A 1 373 ? 140.142 152.135 189.522 1.00 56.07  ? 363 THR A CG2   1 
ATOM   3040 N  N     . ASN A 1 374 ? 136.085 150.727 190.335 1.00 69.40  ? 364 ASN A N     1 
ATOM   3041 C  CA    . ASN A 1 374 ? 134.666 150.437 190.169 1.00 67.91  ? 364 ASN A CA    1 
ATOM   3042 C  C     . ASN A 1 374 ? 134.183 150.791 188.768 1.00 68.89  ? 364 ASN A C     1 
ATOM   3043 O  O     . ASN A 1 374 ? 133.318 150.104 188.216 1.00 69.11  ? 364 ASN A O     1 
ATOM   3044 C  CB    . ASN A 1 374 ? 133.855 151.182 191.224 1.00 68.81  ? 364 ASN A CB    1 
ATOM   3045 C  CG    . ASN A 1 374 ? 134.330 150.891 192.630 1.00 75.19  ? 364 ASN A CG    1 
ATOM   3046 O  OD1   . ASN A 1 374 ? 135.135 149.987 192.848 1.00 73.26  ? 364 ASN A OD1   1 
ATOM   3047 N  ND2   . ASN A 1 374 ? 133.838 151.659 193.593 1.00 75.84  ? 364 ASN A ND2   1 
ATOM   3048 N  N     . ASP A 1 375 ? 134.722 151.863 188.182 1.00 67.92  ? 365 ASP A N     1 
ATOM   3049 C  CA    . ASP A 1 375 ? 134.356 152.224 186.816 1.00 65.48  ? 365 ASP A CA    1 
ATOM   3050 C  C     . ASP A 1 375 ? 134.935 151.237 185.813 1.00 65.66  ? 365 ASP A C     1 
ATOM   3051 O  O     . ASP A 1 375 ? 134.235 150.778 184.900 1.00 63.79  ? 365 ASP A O     1 
ATOM   3052 C  CB    . ASP A 1 375 ? 134.833 153.641 186.502 1.00 71.22  ? 365 ASP A CB    1 
ATOM   3053 C  CG    . ASP A 1 375 ? 134.191 154.681 187.388 1.00 81.29  ? 365 ASP A CG    1 
ATOM   3054 O  OD1   . ASP A 1 375 ? 133.189 154.354 188.059 1.00 78.96  ? 365 ASP A OD1   1 
ATOM   3055 O  OD2   . ASP A 1 375 ? 134.690 155.825 187.418 1.00 87.24  ? 365 ASP A OD2   1 
ATOM   3056 N  N     . GLU A 1 376 ? 136.219 150.905 185.961 1.00 65.63  ? 366 GLU A N     1 
ATOM   3057 C  CA    . GLU A 1 376 ? 136.856 149.986 185.027 1.00 64.49  ? 366 GLU A CA    1 
ATOM   3058 C  C     . GLU A 1 376 ? 136.198 148.616 185.071 1.00 59.28  ? 366 GLU A C     1 
ATOM   3059 O  O     . GLU A 1 376 ? 135.929 148.017 184.024 1.00 58.54  ? 366 GLU A O     1 
ATOM   3060 C  CB    . GLU A 1 376 ? 138.347 149.866 185.336 1.00 66.98  ? 366 GLU A CB    1 
ATOM   3061 C  CG    . GLU A 1 376 ? 139.155 151.119 185.055 1.00 67.98  ? 366 GLU A CG    1 
ATOM   3062 C  CD    . GLU A 1 376 ? 140.632 150.927 185.343 1.00 71.19  ? 366 GLU A CD    1 
ATOM   3063 O  OE1   . GLU A 1 376 ? 141.093 149.767 185.343 1.00 63.71  ? 366 GLU A OE1   1 
ATOM   3064 O  OE2   . GLU A 1 376 ? 141.329 151.935 185.577 1.00 71.14  ? 366 GLU A OE2   1 
ATOM   3065 N  N     . LYS A 1 377 ? 135.932 148.106 186.273 1.00 58.09  ? 367 LYS A N     1 
ATOM   3066 C  CA    . LYS A 1 377 ? 135.292 146.802 186.391 1.00 55.18  ? 367 LYS A CA    1 
ATOM   3067 C  C     . LYS A 1 377 ? 133.916 146.814 185.745 1.00 54.95  ? 367 LYS A C     1 
ATOM   3068 O  O     . LYS A 1 377 ? 133.518 145.842 185.095 1.00 56.00  ? 367 LYS A O     1 
ATOM   3069 C  CB    . LYS A 1 377 ? 135.199 146.394 187.859 1.00 55.17  ? 367 LYS A CB    1 
ATOM   3070 C  CG    . LYS A 1 377 ? 134.663 144.995 188.074 1.00 55.54  ? 367 LYS A CG    1 
ATOM   3071 C  CD    . LYS A 1 377 ? 134.742 144.585 189.531 1.00 53.48  ? 367 LYS A CD    1 
ATOM   3072 C  CE    . LYS A 1 377 ? 136.159 144.678 190.054 1.00 58.07  ? 367 LYS A CE    1 
ATOM   3073 N  NZ    . LYS A 1 377 ? 136.314 143.924 191.327 1.00 53.73  ? 367 LYS A NZ    1 
ATOM   3074 N  N     . LYS A 1 378 ? 133.179 147.915 185.903 1.00 57.80  ? 368 LYS A N     1 
ATOM   3075 C  CA    . LYS A 1 378 ? 131.864 148.022 185.284 1.00 53.94  ? 368 LYS A CA    1 
ATOM   3076 C  C     . LYS A 1 378 ? 131.965 148.023 183.764 1.00 53.11  ? 368 LYS A C     1 
ATOM   3077 O  O     . LYS A 1 378 ? 131.174 147.361 183.084 1.00 53.41  ? 368 LYS A O     1 
ATOM   3078 C  CB    . LYS A 1 378 ? 131.155 149.279 185.786 1.00 54.50  ? 368 LYS A CB    1 
ATOM   3079 C  CG    . LYS A 1 378 ? 129.662 149.306 185.503 1.00 57.28  ? 368 LYS A CG    1 
ATOM   3080 C  CD    . LYS A 1 378 ? 128.954 150.329 186.374 1.00 57.66  ? 368 LYS A CD    1 
ATOM   3081 C  CE    . LYS A 1 378 ? 129.642 151.682 186.315 1.00 57.24  ? 368 LYS A CE    1 
ATOM   3082 N  NZ    . LYS A 1 378 ? 128.984 152.678 187.202 1.00 50.79  ? 368 LYS A NZ    1 
ATOM   3083 N  N     . ASP A 1 379 ? 132.935 148.755 183.209 1.00 55.19  ? 369 ASP A N     1 
ATOM   3084 C  CA    . ASP A 1 379 ? 133.113 148.760 181.758 1.00 52.71  ? 369 ASP A CA    1 
ATOM   3085 C  C     . ASP A 1 379 ? 133.492 147.378 181.238 1.00 50.73  ? 369 ASP A C     1 
ATOM   3086 O  O     . ASP A 1 379 ? 132.971 146.922 180.208 1.00 54.57  ? 369 ASP A O     1 
ATOM   3087 C  CB    . ASP A 1 379 ? 134.176 149.784 181.363 1.00 56.25  ? 369 ASP A CB    1 
ATOM   3088 C  CG    . ASP A 1 379 ? 133.645 151.201 181.357 1.00 61.43  ? 369 ASP A CG    1 
ATOM   3089 O  OD1   . ASP A 1 379 ? 132.566 151.433 181.937 1.00 58.99  ? 369 ASP A OD1   1 
ATOM   3090 O  OD2   . ASP A 1 379 ? 134.307 152.083 180.770 1.00 60.31  ? 369 ASP A OD2   1 
ATOM   3091 N  N     . TYR A 1 380 ? 134.399 146.694 181.936 1.00 51.09  ? 370 TYR A N     1 
ATOM   3092 C  CA    . TYR A 1 380 ? 134.799 145.359 181.507 1.00 48.96  ? 370 TYR A CA    1 
ATOM   3093 C  C     . TYR A 1 380 ? 133.634 144.387 181.585 1.00 46.78  ? 370 TYR A C     1 
ATOM   3094 O  O     . TYR A 1 380 ? 133.477 143.531 180.711 1.00 47.66  ? 370 TYR A O     1 
ATOM   3095 C  CB    . TYR A 1 380 ? 135.978 144.856 182.340 1.00 45.37  ? 370 TYR A CB    1 
ATOM   3096 C  CG    . TYR A 1 380 ? 137.287 145.500 181.962 1.00 42.89  ? 370 TYR A CG    1 
ATOM   3097 C  CD1   . TYR A 1 380 ? 137.846 145.293 180.717 1.00 43.74  ? 370 TYR A CD1   1 
ATOM   3098 C  CD2   . TYR A 1 380 ? 137.964 146.308 182.852 1.00 48.69  ? 370 TYR A CD2   1 
ATOM   3099 C  CE1   . TYR A 1 380 ? 139.041 145.883 180.369 1.00 50.11  ? 370 TYR A CE1   1 
ATOM   3100 C  CE2   . TYR A 1 380 ? 139.153 146.903 182.513 1.00 54.79  ? 370 TYR A CE2   1 
ATOM   3101 C  CZ    . TYR A 1 380 ? 139.690 146.687 181.272 1.00 53.77  ? 370 TYR A CZ    1 
ATOM   3102 O  OH    . TYR A 1 380 ? 140.881 147.277 180.936 1.00 53.13  ? 370 TYR A OH    1 
ATOM   3103 N  N     . GLU A 1 381 ? 132.805 144.499 182.624 1.00 47.35  ? 371 GLU A N     1 
ATOM   3104 C  CA    . GLU A 1 381 ? 131.634 143.637 182.714 1.00 47.98  ? 371 GLU A CA    1 
ATOM   3105 C  C     . GLU A 1 381 ? 130.613 143.967 181.637 1.00 46.72  ? 371 GLU A C     1 
ATOM   3106 O  O     . GLU A 1 381 ? 129.880 143.078 181.191 1.00 47.43  ? 371 GLU A O     1 
ATOM   3107 C  CB    . GLU A 1 381 ? 131.003 143.742 184.100 1.00 54.41  ? 371 GLU A CB    1 
ATOM   3108 C  CG    . GLU A 1 381 ? 131.765 143.007 185.184 1.00 57.96  ? 371 GLU A CG    1 
ATOM   3109 C  CD    . GLU A 1 381 ? 131.147 143.193 186.552 1.00 70.74  ? 371 GLU A CD    1 
ATOM   3110 O  OE1   . GLU A 1 381 ? 130.263 144.064 186.692 1.00 66.02  ? 371 GLU A OE1   1 
ATOM   3111 O  OE2   . GLU A 1 381 ? 131.541 142.469 187.490 1.00 77.95  ? 371 GLU A OE2   1 
ATOM   3112 N  N     . GLU A 1 382 ? 130.535 145.234 181.220 1.00 47.69  ? 372 GLU A N     1 
ATOM   3113 C  CA    . GLU A 1 382 ? 129.684 145.578 180.086 1.00 46.70  ? 372 GLU A CA    1 
ATOM   3114 C  C     . GLU A 1 382 ? 130.164 144.894 178.818 1.00 45.08  ? 372 GLU A C     1 
ATOM   3115 O  O     . GLU A 1 382 ? 129.359 144.353 178.052 1.00 44.36  ? 372 GLU A O     1 
ATOM   3116 C  CB    . GLU A 1 382 ? 129.644 147.091 179.879 1.00 50.85  ? 372 GLU A CB    1 
ATOM   3117 C  CG    . GLU A 1 382 ? 128.794 147.851 180.878 1.00 63.09  ? 372 GLU A CG    1 
ATOM   3118 C  CD    . GLU A 1 382 ? 128.814 149.348 180.632 1.00 73.70  ? 372 GLU A CD    1 
ATOM   3119 O  OE1   . GLU A 1 382 ? 129.694 149.820 179.879 1.00 68.17  ? 372 GLU A OE1   1 
ATOM   3120 O  OE2   . GLU A 1 382 ? 127.946 150.053 181.186 1.00 80.90  ? 372 GLU A OE2   1 
ATOM   3121 N  N     . LEU A 1 383 ? 131.475 144.908 178.578 1.00 43.71  ? 373 LEU A N     1 
ATOM   3122 C  CA    . LEU A 1 383 ? 131.995 144.276 177.368 1.00 37.21  ? 373 LEU A CA    1 
ATOM   3123 C  C     . LEU A 1 383 ? 131.939 142.754 177.439 1.00 38.90  ? 373 LEU A C     1 
ATOM   3124 O  O     . LEU A 1 383 ? 131.828 142.095 176.401 1.00 42.03  ? 373 LEU A O     1 
ATOM   3125 C  CB    . LEU A 1 383 ? 133.422 144.737 177.097 1.00 36.62  ? 373 LEU A CB    1 
ATOM   3126 C  CG    . LEU A 1 383 ? 133.512 146.026 176.288 1.00 36.96  ? 373 LEU A CG    1 
ATOM   3127 C  CD1   . LEU A 1 383 ? 134.910 146.218 175.741 1.00 40.97  ? 373 LEU A CD1   1 
ATOM   3128 C  CD2   . LEU A 1 383 ? 132.502 146.002 175.162 1.00 37.85  ? 373 LEU A CD2   1 
ATOM   3129 N  N     . SER A 1 384 ? 132.015 142.178 178.639 1.00 39.27  ? 374 SER A N     1 
ATOM   3130 C  CA    . SER A 1 384 ? 132.027 140.724 178.762 1.00 36.71  ? 374 SER A CA    1 
ATOM   3131 C  C     . SER A 1 384 ? 130.712 140.099 178.317 1.00 38.60  ? 374 SER A C     1 
ATOM   3132 O  O     . SER A 1 384 ? 130.702 138.957 177.846 1.00 42.74  ? 374 SER A O     1 
ATOM   3133 C  CB    . SER A 1 384 ? 132.341 140.321 180.200 1.00 40.43  ? 374 SER A CB    1 
ATOM   3134 O  OG    . SER A 1 384 ? 131.204 140.455 181.030 1.00 43.06  ? 374 SER A OG    1 
ATOM   3135 N  N     . LYS A 1 385 ? 129.597 140.812 178.465 1.00 37.92  ? 375 LYS A N     1 
ATOM   3136 C  CA    . LYS A 1 385 ? 128.311 140.304 178.009 1.00 37.65  ? 375 LYS A CA    1 
ATOM   3137 C  C     . LYS A 1 385 ? 128.115 140.465 176.511 1.00 43.82  ? 375 LYS A C     1 
ATOM   3138 O  O     . LYS A 1 385 ? 127.177 139.884 175.957 1.00 51.08  ? 375 LYS A O     1 
ATOM   3139 C  CB    . LYS A 1 385 ? 127.169 141.009 178.739 1.00 41.81  ? 375 LYS A CB    1 
ATOM   3140 C  CG    . LYS A 1 385 ? 127.248 140.955 180.253 1.00 45.78  ? 375 LYS A CG    1 
ATOM   3141 C  CD    . LYS A 1 385 ? 126.115 141.760 180.865 1.00 44.56  ? 375 LYS A CD    1 
ATOM   3142 C  CE    . LYS A 1 385 ? 126.197 141.793 182.377 1.00 48.64  ? 375 LYS A CE    1 
ATOM   3143 N  NZ    . LYS A 1 385 ? 125.170 142.706 182.948 1.00 54.33  ? 375 LYS A NZ    1 
ATOM   3144 N  N     . VAL A 1 386 ? 128.968 141.228 175.855 1.00 43.52  ? 376 VAL A N     1 
ATOM   3145 C  CA    . VAL A 1 386 ? 128.871 141.505 174.430 1.00 41.11  ? 376 VAL A CA    1 
ATOM   3146 C  C     . VAL A 1 386 ? 129.824 140.591 173.675 1.00 39.49  ? 376 VAL A C     1 
ATOM   3147 O  O     . VAL A 1 386 ? 130.917 140.267 174.150 1.00 41.05  ? 376 VAL A O     1 
ATOM   3148 C  CB    . VAL A 1 386 ? 129.182 142.990 174.151 1.00 38.07  ? 376 VAL A CB    1 
ATOM   3149 C  CG1   . VAL A 1 386 ? 128.905 143.333 172.719 1.00 40.84  ? 376 VAL A CG1   1 
ATOM   3150 C  CG2   . VAL A 1 386 ? 128.362 143.875 175.058 1.00 39.12  ? 376 VAL A CG2   1 
ATOM   3151 N  N     . VAL A 1 387 ? 129.404 140.165 172.486 1.00 37.42  ? 377 VAL A N     1 
ATOM   3152 C  CA    . VAL A 1 387 ? 130.288 139.425 171.592 1.00 33.96  ? 377 VAL A CA    1 
ATOM   3153 C  C     . VAL A 1 387 ? 131.332 140.403 171.059 1.00 34.30  ? 377 VAL A C     1 
ATOM   3154 O  O     . VAL A 1 387 ? 131.019 141.286 170.259 1.00 34.66  ? 377 VAL A O     1 
ATOM   3155 C  CB    . VAL A 1 387 ? 129.507 138.756 170.455 1.00 34.05  ? 377 VAL A CB    1 
ATOM   3156 C  CG1   . VAL A 1 387 ? 130.446 138.281 169.360 1.00 32.37  ? 377 VAL A CG1   1 
ATOM   3157 C  CG2   . VAL A 1 387 ? 128.704 137.594 170.989 1.00 39.20  ? 377 VAL A CG2   1 
ATOM   3158 N  N     . THR A 1 388 ? 132.570 140.263 171.517 1.00 31.50  ? 378 THR A N     1 
ATOM   3159 C  CA    . THR A 1 388 ? 133.652 141.148 171.122 1.00 26.86  ? 378 THR A CA    1 
ATOM   3160 C  C     . THR A 1 388 ? 134.822 140.310 170.639 1.00 26.07  ? 378 THR A C     1 
ATOM   3161 O  O     . THR A 1 388 ? 134.856 139.094 170.822 1.00 29.49  ? 378 THR A O     1 
ATOM   3162 C  CB    . THR A 1 388 ? 134.087 142.066 172.275 1.00 34.50  ? 378 THR A CB    1 
ATOM   3163 O  OG1   . THR A 1 388 ? 134.161 141.316 173.494 1.00 36.40  ? 378 THR A OG1   1 
ATOM   3164 C  CG2   . THR A 1 388 ? 133.100 143.200 172.454 1.00 37.41  ? 378 THR A CG2   1 
ATOM   3165 N  N     . PHE A 1 389 ? 135.782 140.974 170.002 1.00 29.48  ? 379 PHE A N     1 
ATOM   3166 C  CA    . PHE A 1 389 ? 136.960 140.311 169.466 1.00 28.44  ? 379 PHE A CA    1 
ATOM   3167 C  C     . PHE A 1 389 ? 138.181 141.198 169.648 1.00 28.65  ? 379 PHE A C     1 
ATOM   3168 O  O     . PHE A 1 389 ? 138.074 142.425 169.672 1.00 32.92  ? 379 PHE A O     1 
ATOM   3169 C  CB    . PHE A 1 389 ? 136.800 139.981 167.980 1.00 25.00  ? 379 PHE A CB    1 
ATOM   3170 C  CG    . PHE A 1 389 ? 135.602 139.146 167.668 1.00 26.42  ? 379 PHE A CG    1 
ATOM   3171 C  CD1   . PHE A 1 389 ? 135.679 137.772 167.685 1.00 28.60  ? 379 PHE A CD1   1 
ATOM   3172 C  CD2   . PHE A 1 389 ? 134.398 139.738 167.343 1.00 28.41  ? 379 PHE A CD2   1 
ATOM   3173 C  CE1   . PHE A 1 389 ? 134.578 137.007 167.386 1.00 26.21  ? 379 PHE A CE1   1 
ATOM   3174 C  CE2   . PHE A 1 389 ? 133.300 138.976 167.050 1.00 26.93  ? 379 PHE A CE2   1 
ATOM   3175 C  CZ    . PHE A 1 389 ? 133.390 137.609 167.073 1.00 25.02  ? 379 PHE A CZ    1 
ATOM   3176 N  N     . CYS A 1 390 ? 139.348 140.558 169.759 1.00 27.81  ? 380 CYS A N     1 
ATOM   3177 C  CA    . CYS A 1 390 ? 140.641 141.231 169.756 1.00 29.64  ? 380 CYS A CA    1 
ATOM   3178 C  C     . CYS A 1 390 ? 140.774 142.236 170.894 1.00 30.54  ? 380 CYS A C     1 
ATOM   3179 O  O     . CYS A 1 390 ? 140.699 143.447 170.657 1.00 36.98  ? 380 CYS A O     1 
ATOM   3180 C  CB    . CYS A 1 390 ? 140.874 141.927 168.413 1.00 31.42  ? 380 CYS A CB    1 
ATOM   3181 S  SG    . CYS A 1 390 ? 142.567 142.475 168.131 1.00 48.34  ? 380 CYS A SG    1 
ATOM   3182 N  N     . PRO A 1 391 ? 140.988 141.790 172.132 1.00 27.85  ? 381 PRO A N     1 
ATOM   3183 C  CA    . PRO A 1 391 ? 141.064 142.738 173.250 1.00 26.89  ? 381 PRO A CA    1 
ATOM   3184 C  C     . PRO A 1 391 ? 142.304 143.608 173.190 1.00 28.64  ? 381 PRO A C     1 
ATOM   3185 O  O     . PRO A 1 391 ? 143.114 143.625 174.120 1.00 34.82  ? 381 PRO A O     1 
ATOM   3186 C  CB    . PRO A 1 391 ? 141.091 141.832 174.487 1.00 26.85  ? 381 PRO A CB    1 
ATOM   3187 C  CG    . PRO A 1 391 ? 140.802 140.466 173.997 1.00 29.51  ? 381 PRO A CG    1 
ATOM   3188 C  CD    . PRO A 1 391 ? 141.216 140.411 172.577 1.00 28.87  ? 381 PRO A CD    1 
ATOM   3189 N  N     . PHE A 1 392 ? 142.463 144.322 172.084 1.00 28.75  ? 382 PHE A N     1 
ATOM   3190 C  CA    . PHE A 1 392 ? 143.510 145.323 171.950 1.00 27.61  ? 382 PHE A CA    1 
ATOM   3191 C  C     . PHE A 1 392 ? 143.182 146.486 172.869 1.00 30.04  ? 382 PHE A C     1 
ATOM   3192 O  O     . PHE A 1 392 ? 142.280 147.276 172.579 1.00 36.31  ? 382 PHE A O     1 
ATOM   3193 C  CB    . PHE A 1 392 ? 143.595 145.774 170.498 1.00 33.03  ? 382 PHE A CB    1 
ATOM   3194 C  CG    . PHE A 1 392 ? 144.851 146.510 170.153 1.00 33.21  ? 382 PHE A CG    1 
ATOM   3195 C  CD1   . PHE A 1 392 ? 145.007 147.839 170.496 1.00 28.61  ? 382 PHE A CD1   1 
ATOM   3196 C  CD2   . PHE A 1 392 ? 145.859 145.881 169.448 1.00 27.68  ? 382 PHE A CD2   1 
ATOM   3197 C  CE1   . PHE A 1 392 ? 146.147 148.517 170.162 1.00 31.43  ? 382 PHE A CE1   1 
ATOM   3198 C  CE2   . PHE A 1 392 ? 147.000 146.554 169.111 1.00 25.55  ? 382 PHE A CE2   1 
ATOM   3199 C  CZ    . PHE A 1 392 ? 147.146 147.873 169.465 1.00 35.39  ? 382 PHE A CZ    1 
ATOM   3200 N  N     . GLU A 1 393 ? 143.903 146.595 173.975 1.00 32.18  ? 383 GLU A N     1 
ATOM   3201 C  CA    . GLU A 1 393 ? 143.624 147.592 175.004 1.00 32.87  ? 383 GLU A CA    1 
ATOM   3202 C  C     . GLU A 1 393 ? 144.701 148.665 174.914 1.00 33.04  ? 383 GLU A C     1 
ATOM   3203 O  O     . GLU A 1 393 ? 145.757 148.553 175.534 1.00 37.67  ? 383 GLU A O     1 
ATOM   3204 C  CB    . GLU A 1 393 ? 143.584 146.949 176.376 1.00 33.90  ? 383 GLU A CB    1 
ATOM   3205 C  CG    . GLU A 1 393 ? 142.328 146.162 176.626 1.00 39.09  ? 383 GLU A CG    1 
ATOM   3206 C  CD    . GLU A 1 393 ? 141.261 146.997 177.289 1.00 49.07  ? 383 GLU A CD    1 
ATOM   3207 O  OE1   . GLU A 1 393 ? 141.520 148.194 177.541 1.00 51.16  ? 383 GLU A OE1   1 
ATOM   3208 O  OE2   . GLU A 1 393 ? 140.162 146.464 177.547 1.00 45.25  ? 383 GLU A OE2   1 
ATOM   3209 N  N     . ASN A 1 394 ? 144.415 149.717 174.146 1.00 32.27  ? 384 ASN A N     1 
ATOM   3210 C  CA    . ASN A 1 394 ? 145.431 150.722 173.847 1.00 32.45  ? 384 ASN A CA    1 
ATOM   3211 C  C     . ASN A 1 394 ? 145.952 151.392 175.108 1.00 35.35  ? 384 ASN A C     1 
ATOM   3212 O  O     . ASN A 1 394 ? 147.121 151.785 175.173 1.00 39.23  ? 384 ASN A O     1 
ATOM   3213 C  CB    . ASN A 1 394 ? 144.867 151.776 172.902 1.00 33.84  ? 384 ASN A CB    1 
ATOM   3214 C  CG    . ASN A 1 394 ? 145.947 152.510 172.156 1.00 43.49  ? 384 ASN A CG    1 
ATOM   3215 O  OD1   . ASN A 1 394 ? 146.804 151.899 171.521 1.00 44.17  ? 384 ASN A OD1   1 
ATOM   3216 N  ND2   . ASN A 1 394 ? 145.940 153.826 172.258 1.00 37.19  ? 384 ASN A ND2   1 
ATOM   3217 N  N     . GLN A 1 395 ? 145.097 151.544 176.116 1.00 36.87  ? 385 GLN A N     1 
ATOM   3218 C  CA    . GLN A 1 395 ? 145.499 152.267 177.315 1.00 35.02  ? 385 GLN A CA    1 
ATOM   3219 C  C     . GLN A 1 395 ? 146.485 151.447 178.136 1.00 33.36  ? 385 GLN A C     1 
ATOM   3220 O  O     . GLN A 1 395 ? 147.457 151.983 178.679 1.00 35.17  ? 385 GLN A O     1 
ATOM   3221 C  CB    . GLN A 1 395 ? 144.254 152.633 178.123 1.00 45.11  ? 385 GLN A CB    1 
ATOM   3222 C  CG    . GLN A 1 395 ? 144.489 153.505 179.336 1.00 45.29  ? 385 GLN A CG    1 
ATOM   3223 C  CD    . GLN A 1 395 ? 143.187 153.882 180.010 1.00 51.87  ? 385 GLN A CD    1 
ATOM   3224 O  OE1   . GLN A 1 395 ? 142.113 153.449 179.594 1.00 50.21  ? 385 GLN A OE1   1 
ATOM   3225 N  NE2   . GLN A 1 395 ? 143.269 154.722 181.032 1.00 54.67  ? 385 GLN A NE2   1 
ATOM   3226 N  N     . LEU A 1 396 ? 146.260 150.135 178.221 1.00 30.86  ? 386 LEU A N     1 
ATOM   3227 C  CA    . LEU A 1 396 ? 147.205 149.261 178.906 1.00 33.20  ? 386 LEU A CA    1 
ATOM   3228 C  C     . LEU A 1 396 ? 148.438 148.977 178.059 1.00 37.55  ? 386 LEU A C     1 
ATOM   3229 O  O     . LEU A 1 396 ? 149.527 148.773 178.604 1.00 43.67  ? 386 LEU A O     1 
ATOM   3230 C  CB    . LEU A 1 396 ? 146.525 147.950 179.285 1.00 30.06  ? 386 LEU A CB    1 
ATOM   3231 C  CG    . LEU A 1 396 ? 145.145 148.042 179.926 1.00 33.39  ? 386 LEU A CG    1 
ATOM   3232 C  CD1   . LEU A 1 396 ? 144.622 146.656 180.232 1.00 38.03  ? 386 LEU A CD1   1 
ATOM   3233 C  CD2   . LEU A 1 396 ? 145.205 148.875 181.186 1.00 38.92  ? 386 LEU A CD2   1 
ATOM   3234 N  N     . LEU A 1 397 ? 148.292 148.944 176.735 1.00 32.91  ? 387 LEU A N     1 
ATOM   3235 C  CA    . LEU A 1 397 ? 149.412 148.579 175.877 1.00 28.01  ? 387 LEU A CA    1 
ATOM   3236 C  C     . LEU A 1 397 ? 150.537 149.599 175.959 1.00 32.63  ? 387 LEU A C     1 
ATOM   3237 O  O     . LEU A 1 397 ? 151.713 149.241 175.842 1.00 37.11  ? 387 LEU A O     1 
ATOM   3238 C  CB    . LEU A 1 397 ? 148.938 148.425 174.435 1.00 27.43  ? 387 LEU A CB    1 
ATOM   3239 C  CG    . LEU A 1 397 ? 149.965 147.823 173.478 1.00 26.14  ? 387 LEU A CG    1 
ATOM   3240 C  CD1   . LEU A 1 397 ? 150.346 146.425 173.920 1.00 31.02  ? 387 LEU A CD1   1 
ATOM   3241 C  CD2   . LEU A 1 397 ? 149.428 147.811 172.076 1.00 22.54  ? 387 LEU A CD2   1 
ATOM   3242 N  N     . PHE A 1 398 ? 150.201 150.874 176.150 1.00 29.58  ? 388 PHE A N     1 
ATOM   3243 C  CA    . PHE A 1 398 ? 151.231 151.897 176.262 1.00 28.36  ? 388 PHE A CA    1 
ATOM   3244 C  C     . PHE A 1 398 ? 152.116 151.686 177.481 1.00 34.87  ? 388 PHE A C     1 
ATOM   3245 O  O     . PHE A 1 398 ? 153.205 152.262 177.551 1.00 40.85  ? 388 PHE A O     1 
ATOM   3246 C  CB    . PHE A 1 398 ? 150.586 153.280 176.309 1.00 32.51  ? 388 PHE A CB    1 
ATOM   3247 C  CG    . PHE A 1 398 ? 151.554 154.409 176.121 1.00 28.85  ? 388 PHE A CG    1 
ATOM   3248 C  CD1   . PHE A 1 398 ? 152.182 154.600 174.912 1.00 27.88  ? 388 PHE A CD1   1 
ATOM   3249 C  CD2   . PHE A 1 398 ? 151.830 155.282 177.157 1.00 34.41  ? 388 PHE A CD2   1 
ATOM   3250 C  CE1   . PHE A 1 398 ? 153.064 155.630 174.738 1.00 32.96  ? 388 PHE A CE1   1 
ATOM   3251 C  CE2   . PHE A 1 398 ? 152.711 156.317 176.988 1.00 34.13  ? 388 PHE A CE2   1 
ATOM   3252 C  CZ    . PHE A 1 398 ? 153.330 156.491 175.779 1.00 35.91  ? 388 PHE A CZ    1 
ATOM   3253 N  N     . ALA A 1 399 ? 151.675 150.871 178.441 1.00 34.36  ? 389 ALA A N     1 
ATOM   3254 C  CA    . ALA A 1 399 ? 152.497 150.579 179.608 1.00 37.77  ? 389 ALA A CA    1 
ATOM   3255 C  C     . ALA A 1 399 ? 153.756 149.804 179.242 1.00 34.01  ? 389 ALA A C     1 
ATOM   3256 O  O     . ALA A 1 399 ? 154.751 149.867 179.971 1.00 35.86  ? 389 ALA A O     1 
ATOM   3257 C  CB    . ALA A 1 399 ? 151.680 149.804 180.636 1.00 39.01  ? 389 ALA A CB    1 
ATOM   3258 N  N     . ARG A 1 400 ? 153.733 149.062 178.133 1.00 35.40  ? 390 ARG A N     1 
ATOM   3259 C  CA    . ARG A 1 400 ? 154.933 148.363 177.689 1.00 35.79  ? 390 ARG A CA    1 
ATOM   3260 C  C     . ARG A 1 400 ? 156.015 149.336 177.256 1.00 35.60  ? 390 ARG A C     1 
ATOM   3261 O  O     . ARG A 1 400 ? 157.206 149.028 177.366 1.00 38.41  ? 390 ARG A O     1 
ATOM   3262 C  CB    . ARG A 1 400 ? 154.604 147.414 176.543 1.00 28.82  ? 390 ARG A CB    1 
ATOM   3263 C  CG    . ARG A 1 400 ? 153.860 146.174 176.959 1.00 28.45  ? 390 ARG A CG    1 
ATOM   3264 C  CD    . ARG A 1 400 ? 153.826 145.185 175.823 1.00 34.88  ? 390 ARG A CD    1 
ATOM   3265 N  NE    . ARG A 1 400 ? 152.934 144.067 176.094 1.00 34.06  ? 390 ARG A NE    1 
ATOM   3266 C  CZ    . ARG A 1 400 ? 152.802 143.013 175.304 1.00 28.31  ? 390 ARG A CZ    1 
ATOM   3267 N  NH1   . ARG A 1 400 ? 153.495 142.901 174.187 1.00 26.87  ? 390 ARG A NH1   1 
ATOM   3268 N  NH2   . ARG A 1 400 ? 151.959 142.048 175.646 1.00 31.99  ? 390 ARG A NH2   1 
ATOM   3269 N  N     . TYR A 1 401 ? 155.625 150.503 176.755 1.00 30.42  ? 391 TYR A N     1 
ATOM   3270 C  CA    . TYR A 1 401 ? 156.583 151.528 176.372 1.00 31.60  ? 391 TYR A CA    1 
ATOM   3271 C  C     . TYR A 1 401 ? 156.909 152.434 177.555 1.00 36.51  ? 391 TYR A C     1 
ATOM   3272 O  O     . TYR A 1 401 ? 158.067 152.533 177.971 1.00 45.09  ? 391 TYR A O     1 
ATOM   3273 C  CB    . TYR A 1 401 ? 156.030 152.335 175.197 1.00 32.41  ? 391 TYR A CB    1 
ATOM   3274 C  CG    . TYR A 1 401 ? 156.947 153.425 174.719 1.00 32.02  ? 391 TYR A CG    1 
ATOM   3275 C  CD1   . TYR A 1 401 ? 158.118 153.125 174.046 1.00 35.60  ? 391 TYR A CD1   1 
ATOM   3276 C  CD2   . TYR A 1 401 ? 156.640 154.754 174.941 1.00 34.56  ? 391 TYR A CD2   1 
ATOM   3277 C  CE1   . TYR A 1 401 ? 158.957 154.119 173.608 1.00 41.41  ? 391 TYR A CE1   1 
ATOM   3278 C  CE2   . TYR A 1 401 ? 157.469 155.752 174.508 1.00 41.68  ? 391 TYR A CE2   1 
ATOM   3279 C  CZ    . TYR A 1 401 ? 158.627 155.433 173.843 1.00 42.96  ? 391 TYR A CZ    1 
ATOM   3280 O  OH    . TYR A 1 401 ? 159.456 156.439 173.411 1.00 43.89  ? 391 TYR A OH    1 
ATOM   3281 N  N     . ASN A 1 402 ? 155.895 153.088 178.113 1.00 37.34  ? 392 ASN A N     1 
ATOM   3282 C  CA    . ASN A 1 402 ? 156.074 153.927 179.292 1.00 41.77  ? 392 ASN A CA    1 
ATOM   3283 C  C     . ASN A 1 402 ? 156.136 153.034 180.523 1.00 48.58  ? 392 ASN A C     1 
ATOM   3284 O  O     . ASN A 1 402 ? 155.110 152.519 180.976 1.00 47.14  ? 392 ASN A O     1 
ATOM   3285 C  CB    . ASN A 1 402 ? 154.937 154.935 179.410 1.00 39.02  ? 392 ASN A CB    1 
ATOM   3286 C  CG    . ASN A 1 402 ? 155.251 156.053 180.379 1.00 45.59  ? 392 ASN A CG    1 
ATOM   3287 O  OD1   . ASN A 1 402 ? 156.391 156.214 180.807 1.00 53.13  ? 392 ASN A OD1   1 
ATOM   3288 N  ND2   . ASN A 1 402 ? 154.237 156.823 180.742 1.00 45.29  ? 392 ASN A ND2   1 
ATOM   3289 N  N     . LYS A 1 403 ? 157.336 152.854 181.072 1.00 53.27  ? 393 LYS A N     1 
ATOM   3290 C  CA    . LYS A 1 403 ? 157.514 151.978 182.222 1.00 50.90  ? 393 LYS A CA    1 
ATOM   3291 C  C     . LYS A 1 403 ? 157.039 152.602 183.525 1.00 52.35  ? 393 LYS A C     1 
ATOM   3292 O  O     . LYS A 1 403 ? 156.937 151.891 184.530 1.00 56.70  ? 393 LYS A O     1 
ATOM   3293 C  CB    . LYS A 1 403 ? 158.982 151.573 182.350 1.00 49.13  ? 393 LYS A CB    1 
ATOM   3294 C  CG    . LYS A 1 403 ? 159.510 150.823 181.148 1.00 50.63  ? 393 LYS A CG    1 
ATOM   3295 C  CD    . LYS A 1 403 ? 159.125 149.361 181.206 1.00 59.16  ? 393 LYS A CD    1 
ATOM   3296 C  CE    . LYS A 1 403 ? 159.775 148.575 180.082 1.00 54.00  ? 393 LYS A CE    1 
ATOM   3297 N  NZ    . LYS A 1 403 ? 159.846 147.127 180.407 1.00 52.75  ? 393 LYS A NZ    1 
ATOM   3298 N  N     . MET A 1 404 ? 156.750 153.899 183.538 1.00 51.05  ? 394 MET A N     1 
ATOM   3299 C  CA    . MET A 1 404 ? 156.227 154.570 184.717 1.00 57.46  ? 394 MET A CA    1 
ATOM   3300 C  C     . MET A 1 404 ? 154.723 154.794 184.642 1.00 54.76  ? 394 MET A C     1 
ATOM   3301 O  O     . MET A 1 404 ? 154.174 155.535 185.461 1.00 56.30  ? 394 MET A O     1 
ATOM   3302 C  CB    . MET A 1 404 ? 156.954 155.896 184.927 1.00 62.19  ? 394 MET A CB    1 
ATOM   3303 C  CG    . MET A 1 404 ? 158.462 155.743 185.033 1.00 66.35  ? 394 MET A CG    1 
ATOM   3304 S  SD    . MET A 1 404 ? 159.301 157.264 185.502 1.00 100.20 ? 394 MET A SD    1 
ATOM   3305 C  CE    . MET A 1 404 ? 160.927 156.631 185.903 1.00 88.70  ? 394 MET A CE    1 
ATOM   3306 N  N     . SER A 1 405 ? 154.050 154.173 183.680 1.00 50.96  ? 395 SER A N     1 
ATOM   3307 C  CA    . SER A 1 405 ? 152.609 154.315 183.557 1.00 51.90  ? 395 SER A CA    1 
ATOM   3308 C  C     . SER A 1 405 ? 151.902 153.684 184.748 1.00 52.27  ? 395 SER A C     1 
ATOM   3309 O  O     . SER A 1 405 ? 152.390 152.729 185.357 1.00 52.75  ? 395 SER A O     1 
ATOM   3310 C  CB    . SER A 1 405 ? 152.122 153.669 182.261 1.00 51.43  ? 395 SER A CB    1 
ATOM   3311 O  OG    . SER A 1 405 ? 150.725 153.443 182.304 1.00 45.74  ? 395 SER A OG    1 
ATOM   3312 N  N     . LYS A 1 406 ? 150.734 154.234 185.083 1.00 48.62  ? 396 LYS A N     1 
ATOM   3313 C  CA    . LYS A 1 406 ? 149.950 153.702 186.188 1.00 51.13  ? 396 LYS A CA    1 
ATOM   3314 C  C     . LYS A 1 406 ? 149.285 152.377 185.850 1.00 49.93  ? 396 LYS A C     1 
ATOM   3315 O  O     . LYS A 1 406 ? 148.730 151.735 186.747 1.00 48.63  ? 396 LYS A O     1 
ATOM   3316 C  CB    . LYS A 1 406 ? 148.898 154.721 186.620 1.00 55.43  ? 396 LYS A CB    1 
ATOM   3317 C  CG    . LYS A 1 406 ? 149.492 155.986 187.218 1.00 64.29  ? 396 LYS A CG    1 
ATOM   3318 C  CD    . LYS A 1 406 ? 148.468 157.109 187.306 1.00 73.11  ? 396 LYS A CD    1 
ATOM   3319 C  CE    . LYS A 1 406 ? 149.107 158.392 187.818 1.00 68.44  ? 396 LYS A CE    1 
ATOM   3320 N  NZ    . LYS A 1 406 ? 148.189 159.558 187.706 1.00 50.58  ? 396 LYS A NZ    1 
ATOM   3321 N  N     . PHE A 1 407 ? 149.323 151.958 184.586 1.00 51.32  ? 397 PHE A N     1 
ATOM   3322 C  CA    . PHE A 1 407 ? 148.763 150.686 184.155 1.00 47.72  ? 397 PHE A CA    1 
ATOM   3323 C  C     . PHE A 1 407 ? 149.840 149.648 183.886 1.00 44.92  ? 397 PHE A C     1 
ATOM   3324 O  O     . PHE A 1 407 ? 149.583 148.666 183.184 1.00 48.56  ? 397 PHE A O     1 
ATOM   3325 C  CB    . PHE A 1 407 ? 147.904 150.887 182.908 1.00 43.46  ? 397 PHE A CB    1 
ATOM   3326 C  CG    . PHE A 1 407 ? 147.066 152.123 182.953 1.00 48.35  ? 397 PHE A CG    1 
ATOM   3327 C  CD1   . PHE A 1 407 ? 145.858 152.131 183.622 1.00 52.49  ? 397 PHE A CD1   1 
ATOM   3328 C  CD2   . PHE A 1 407 ? 147.493 153.284 182.336 1.00 48.32  ? 397 PHE A CD2   1 
ATOM   3329 C  CE1   . PHE A 1 407 ? 145.091 153.268 183.670 1.00 53.61  ? 397 PHE A CE1   1 
ATOM   3330 C  CE2   . PHE A 1 407 ? 146.729 154.425 182.382 1.00 50.34  ? 397 PHE A CE2   1 
ATOM   3331 C  CZ    . PHE A 1 407 ? 145.529 154.417 183.052 1.00 51.68  ? 397 PHE A CZ    1 
ATOM   3332 N  N     . CYS A 1 408 ? 151.045 149.853 184.420 1.00 46.08  ? 398 CYS A N     1 
ATOM   3333 C  CA    . CYS A 1 408 ? 152.152 148.954 184.123 1.00 44.91  ? 398 CYS A CA    1 
ATOM   3334 C  C     . CYS A 1 408 ? 151.903 147.552 184.660 1.00 45.52  ? 398 CYS A C     1 
ATOM   3335 O  O     . CYS A 1 408 ? 152.252 146.570 183.998 1.00 46.92  ? 398 CYS A O     1 
ATOM   3336 C  CB    . CYS A 1 408 ? 153.450 149.524 184.687 1.00 45.78  ? 398 CYS A CB    1 
ATOM   3337 S  SG    . CYS A 1 408 ? 154.951 148.849 183.952 1.00 66.59  ? 398 CYS A SG    1 
ATOM   3338 N  N     . LYS A 1 409 ? 151.305 147.430 185.842 1.00 46.48  ? 399 LYS A N     1 
ATOM   3339 C  CA    . LYS A 1 409 ? 151.028 146.108 186.386 1.00 47.25  ? 399 LYS A CA    1 
ATOM   3340 C  C     . LYS A 1 409 ? 149.776 145.483 185.789 1.00 45.42  ? 399 LYS A C     1 
ATOM   3341 O  O     . LYS A 1 409 ? 149.710 144.257 185.654 1.00 43.07  ? 399 LYS A O     1 
ATOM   3342 C  CB    . LYS A 1 409 ? 150.904 146.173 187.911 1.00 43.28  ? 399 LYS A CB    1 
ATOM   3343 C  CG    . LYS A 1 409 ? 150.557 144.838 188.546 1.00 45.63  ? 399 LYS A CG    1 
ATOM   3344 C  CD    . LYS A 1 409 ? 150.546 144.901 190.059 1.00 49.07  ? 399 LYS A CD    1 
ATOM   3345 C  CE    . LYS A 1 409 ? 150.122 143.565 190.645 1.00 50.65  ? 399 LYS A CE    1 
ATOM   3346 N  NZ    . LYS A 1 409 ? 150.897 142.436 190.062 1.00 43.27  ? 399 LYS A NZ    1 
ATOM   3347 N  N     . LYS A 1 410 ? 148.780 146.293 185.422 1.00 46.48  ? 400 LYS A N     1 
ATOM   3348 C  CA    . LYS A 1 410 ? 147.620 145.750 184.725 1.00 44.43  ? 400 LYS A CA    1 
ATOM   3349 C  C     . LYS A 1 410 ? 148.020 145.155 183.385 1.00 41.63  ? 400 LYS A C     1 
ATOM   3350 O  O     . LYS A 1 410 ? 147.515 144.099 182.991 1.00 44.72  ? 400 LYS A O     1 
ATOM   3351 C  CB    . LYS A 1 410 ? 146.561 146.828 184.520 1.00 40.91  ? 400 LYS A CB    1 
ATOM   3352 C  CG    . LYS A 1 410 ? 145.847 147.268 185.773 1.00 49.27  ? 400 LYS A CG    1 
ATOM   3353 C  CD    . LYS A 1 410 ? 144.849 148.356 185.437 1.00 56.64  ? 400 LYS A CD    1 
ATOM   3354 C  CE    . LYS A 1 410 ? 144.663 149.313 186.592 1.00 57.30  ? 400 LYS A CE    1 
ATOM   3355 N  NZ    . LYS A 1 410 ? 143.872 150.501 186.181 1.00 64.67  ? 400 LYS A NZ    1 
ATOM   3356 N  N     . GLU A 1 411 ? 148.918 145.826 182.664 1.00 40.39  ? 401 GLU A N     1 
ATOM   3357 C  CA    . GLU A 1 411 ? 149.383 145.299 181.387 1.00 40.28  ? 401 GLU A CA    1 
ATOM   3358 C  C     . GLU A 1 411 ? 150.123 143.981 181.570 1.00 38.95  ? 401 GLU A C     1 
ATOM   3359 O  O     . GLU A 1 411 ? 149.947 143.052 180.776 1.00 43.51  ? 401 GLU A O     1 
ATOM   3360 C  CB    . GLU A 1 411 ? 150.266 146.334 180.687 1.00 40.59  ? 401 GLU A CB    1 
ATOM   3361 C  CG    . GLU A 1 411 ? 151.181 145.784 179.595 1.00 41.12  ? 401 GLU A CG    1 
ATOM   3362 C  CD    . GLU A 1 411 ? 150.442 145.106 178.450 1.00 38.34  ? 401 GLU A CD    1 
ATOM   3363 O  OE1   . GLU A 1 411 ? 149.219 145.301 178.308 1.00 41.12  ? 401 GLU A OE1   1 
ATOM   3364 O  OE2   . GLU A 1 411 ? 151.094 144.371 177.683 1.00 31.84  ? 401 GLU A OE2   1 
ATOM   3365 N  N     . GLN A 1 412 ? 150.948 143.875 182.613 1.00 36.28  ? 402 GLN A N     1 
ATOM   3366 C  CA    . GLN A 1 412 ? 151.666 142.628 182.858 1.00 36.53  ? 402 GLN A CA    1 
ATOM   3367 C  C     . GLN A 1 412 ? 150.712 141.480 183.157 1.00 35.52  ? 402 GLN A C     1 
ATOM   3368 O  O     . GLN A 1 412 ? 150.892 140.370 182.648 1.00 36.62  ? 402 GLN A O     1 
ATOM   3369 C  CB    . GLN A 1 412 ? 152.652 142.800 184.010 1.00 40.60  ? 402 GLN A CB    1 
ATOM   3370 C  CG    . GLN A 1 412 ? 153.816 143.706 183.717 1.00 42.83  ? 402 GLN A CG    1 
ATOM   3371 C  CD    . GLN A 1 412 ? 154.619 144.001 184.959 1.00 56.90  ? 402 GLN A CD    1 
ATOM   3372 O  OE1   . GLN A 1 412 ? 154.461 143.333 185.980 1.00 55.05  ? 402 GLN A OE1   1 
ATOM   3373 N  NE2   . GLN A 1 412 ? 155.479 145.010 184.886 1.00 54.69  ? 402 GLN A NE2   1 
ATOM   3374 N  N     . VAL A 1 413 ? 149.697 141.723 183.987 1.00 38.36  ? 403 VAL A N     1 
ATOM   3375 C  CA    . VAL A 1 413 ? 148.742 140.670 184.320 1.00 37.45  ? 403 VAL A CA    1 
ATOM   3376 C  C     . VAL A 1 413 ? 147.906 140.299 183.101 1.00 36.05  ? 403 VAL A C     1 
ATOM   3377 O  O     . VAL A 1 413 ? 147.643 139.117 182.851 1.00 41.18  ? 403 VAL A O     1 
ATOM   3378 C  CB    . VAL A 1 413 ? 147.864 141.099 185.509 1.00 39.39  ? 403 VAL A CB    1 
ATOM   3379 C  CG1   . VAL A 1 413 ? 146.771 140.084 185.758 1.00 45.12  ? 403 VAL A CG1   1 
ATOM   3380 C  CG2   . VAL A 1 413 ? 148.708 141.258 186.750 1.00 37.09  ? 403 VAL A CG2   1 
ATOM   3381 N  N     . LEU A 1 414 ? 147.480 141.296 182.323 1.00 34.82  ? 404 LEU A N     1 
ATOM   3382 C  CA    . LEU A 1 414 ? 146.767 141.022 181.080 1.00 34.16  ? 404 LEU A CA    1 
ATOM   3383 C  C     . LEU A 1 414 ? 147.593 140.138 180.159 1.00 35.99  ? 404 LEU A C     1 
ATOM   3384 O  O     . LEU A 1 414 ? 147.100 139.135 179.634 1.00 37.63  ? 404 LEU A O     1 
ATOM   3385 C  CB    . LEU A 1 414 ? 146.424 142.331 180.374 1.00 35.62  ? 404 LEU A CB    1 
ATOM   3386 C  CG    . LEU A 1 414 ? 145.363 142.275 179.276 1.00 38.92  ? 404 LEU A CG    1 
ATOM   3387 C  CD1   . LEU A 1 414 ? 143.986 142.279 179.881 1.00 39.95  ? 404 LEU A CD1   1 
ATOM   3388 C  CD2   . LEU A 1 414 ? 145.523 143.435 178.322 1.00 40.86  ? 404 LEU A CD2   1 
ATOM   3389 N  N     . SER A 1 415 ? 148.859 140.503 179.949 1.00 34.48  ? 405 SER A N     1 
ATOM   3390 C  CA    . SER A 1 415 ? 149.718 139.738 179.057 1.00 31.33  ? 405 SER A CA    1 
ATOM   3391 C  C     . SER A 1 415 ? 149.945 138.327 179.578 1.00 32.74  ? 405 SER A C     1 
ATOM   3392 O  O     . SER A 1 415 ? 149.883 137.361 178.812 1.00 39.31  ? 405 SER A O     1 
ATOM   3393 C  CB    . SER A 1 415 ? 151.046 140.467 178.873 1.00 31.78  ? 405 SER A CB    1 
ATOM   3394 O  OG    . SER A 1 415 ? 150.851 141.738 178.285 1.00 32.19  ? 405 SER A OG    1 
ATOM   3395 N  N     . LYS A 1 416 ? 150.203 138.184 180.878 1.00 30.90  ? 406 LYS A N     1 
ATOM   3396 C  CA    . LYS A 1 416 ? 150.440 136.859 181.439 1.00 32.56  ? 406 LYS A CA    1 
ATOM   3397 C  C     . LYS A 1 416 ? 149.209 135.971 181.307 1.00 33.41  ? 406 LYS A C     1 
ATOM   3398 O  O     . LYS A 1 416 ? 149.318 134.803 180.919 1.00 34.36  ? 406 LYS A O     1 
ATOM   3399 C  CB    . LYS A 1 416 ? 150.865 136.983 182.901 1.00 35.33  ? 406 LYS A CB    1 
ATOM   3400 C  CG    . LYS A 1 416 ? 150.757 135.696 183.694 1.00 35.26  ? 406 LYS A CG    1 
ATOM   3401 C  CD    . LYS A 1 416 ? 150.973 135.944 185.172 1.00 34.58  ? 406 LYS A CD    1 
ATOM   3402 C  CE    . LYS A 1 416 ? 150.106 137.083 185.666 1.00 45.51  ? 406 LYS A CE    1 
ATOM   3403 N  NZ    . LYS A 1 416 ? 150.420 137.441 187.074 1.00 48.09  ? 406 LYS A NZ    1 
ATOM   3404 N  N     . LEU A 1 417 ? 148.026 136.511 181.601 1.00 29.87  ? 407 LEU A N     1 
ATOM   3405 C  CA    . LEU A 1 417 ? 146.805 135.728 181.466 1.00 29.21  ? 407 LEU A CA    1 
ATOM   3406 C  C     . LEU A 1 417 ? 146.508 135.380 180.015 1.00 32.57  ? 407 LEU A C     1 
ATOM   3407 O  O     . LEU A 1 417 ? 146.076 134.259 179.724 1.00 38.49  ? 407 LEU A O     1 
ATOM   3408 C  CB    . LEU A 1 417 ? 145.628 136.486 182.068 1.00 38.44  ? 407 LEU A CB    1 
ATOM   3409 C  CG    . LEU A 1 417 ? 145.661 136.693 183.575 1.00 39.13  ? 407 LEU A CG    1 
ATOM   3410 C  CD1   . LEU A 1 417 ? 144.371 137.344 184.029 1.00 38.17  ? 407 LEU A CD1   1 
ATOM   3411 C  CD2   . LEU A 1 417 ? 145.888 135.374 184.275 1.00 34.30  ? 407 LEU A CD2   1 
ATOM   3412 N  N     . LEU A 1 418 ? 146.716 136.320 179.095 1.00 32.58  ? 408 LEU A N     1 
ATOM   3413 C  CA    . LEU A 1 418 ? 146.453 136.039 177.690 1.00 29.05  ? 408 LEU A CA    1 
ATOM   3414 C  C     . LEU A 1 418 ? 147.389 134.962 177.161 1.00 27.98  ? 408 LEU A C     1 
ATOM   3415 O  O     . LEU A 1 418 ? 146.955 134.049 176.452 1.00 32.63  ? 408 LEU A O     1 
ATOM   3416 C  CB    . LEU A 1 418 ? 146.581 137.323 176.871 1.00 30.98  ? 408 LEU A CB    1 
ATOM   3417 C  CG    . LEU A 1 418 ? 145.313 138.175 176.778 1.00 32.69  ? 408 LEU A CG    1 
ATOM   3418 C  CD1   . LEU A 1 418 ? 145.529 139.363 175.864 1.00 30.51  ? 408 LEU A CD1   1 
ATOM   3419 C  CD2   . LEU A 1 418 ? 144.120 137.347 176.323 1.00 25.74  ? 408 LEU A CD2   1 
ATOM   3420 N  N     . TYR A 1 419 ? 148.673 135.038 177.513 1.00 27.62  ? 409 TYR A N     1 
ATOM   3421 C  CA    . TYR A 1 419 ? 149.615 134.020 177.071 1.00 26.30  ? 409 TYR A CA    1 
ATOM   3422 C  C     . TYR A 1 419 ? 149.359 132.679 177.753 1.00 30.71  ? 409 TYR A C     1 
ATOM   3423 O  O     . TYR A 1 419 ? 149.598 131.624 177.154 1.00 38.66  ? 409 TYR A O     1 
ATOM   3424 C  CB    . TYR A 1 419 ? 151.040 134.499 177.320 1.00 24.65  ? 409 TYR A CB    1 
ATOM   3425 C  CG    . TYR A 1 419 ? 151.580 135.431 176.261 1.00 22.92  ? 409 TYR A CG    1 
ATOM   3426 C  CD1   . TYR A 1 419 ? 152.050 134.945 175.052 1.00 21.04  ? 409 TYR A CD1   1 
ATOM   3427 C  CD2   . TYR A 1 419 ? 151.632 136.796 176.474 1.00 20.54  ? 409 TYR A CD2   1 
ATOM   3428 C  CE1   . TYR A 1 419 ? 152.548 135.793 174.090 1.00 19.12  ? 409 TYR A CE1   1 
ATOM   3429 C  CE2   . TYR A 1 419 ? 152.127 137.649 175.519 1.00 22.32  ? 409 TYR A CE2   1 
ATOM   3430 C  CZ    . TYR A 1 419 ? 152.584 137.145 174.328 1.00 21.26  ? 409 TYR A CZ    1 
ATOM   3431 O  OH    . TYR A 1 419 ? 153.078 138.004 173.375 1.00 17.84  ? 409 TYR A OH    1 
ATOM   3432 N  N     . ALA A 1 420 ? 148.865 132.690 178.993 1.00 28.16  ? 410 ALA A N     1 
ATOM   3433 C  CA    . ALA A 1 420 ? 148.452 131.444 179.629 1.00 28.34  ? 410 ALA A CA    1 
ATOM   3434 C  C     . ALA A 1 420 ? 147.289 130.809 178.883 1.00 31.14  ? 410 ALA A C     1 
ATOM   3435 O  O     . ALA A 1 420 ? 147.255 129.590 178.687 1.00 33.55  ? 410 ALA A O     1 
ATOM   3436 C  CB    . ALA A 1 420 ? 148.076 131.697 181.086 1.00 26.65  ? 410 ALA A CB    1 
ATOM   3437 N  N     . LEU A 1 421 ? 146.318 131.621 178.469 1.00 28.68  ? 411 LEU A N     1 
ATOM   3438 C  CA    . LEU A 1 421 ? 145.222 131.098 177.661 1.00 27.74  ? 411 LEU A CA    1 
ATOM   3439 C  C     . LEU A 1 421 ? 145.729 130.564 176.332 1.00 30.33  ? 411 LEU A C     1 
ATOM   3440 O  O     . LEU A 1 421 ? 145.219 129.564 175.820 1.00 35.21  ? 411 LEU A O     1 
ATOM   3441 C  CB    . LEU A 1 421 ? 144.172 132.178 177.429 1.00 27.92  ? 411 LEU A CB    1 
ATOM   3442 C  CG    . LEU A 1 421 ? 142.976 131.701 176.616 1.00 26.22  ? 411 LEU A CG    1 
ATOM   3443 C  CD1   . LEU A 1 421 ? 142.266 130.577 177.328 1.00 27.41  ? 411 LEU A CD1   1 
ATOM   3444 C  CD2   . LEU A 1 421 ? 142.050 132.847 176.375 1.00 27.92  ? 411 LEU A CD2   1 
ATOM   3445 N  N     . GLN A 1 422 ? 146.719 131.231 175.748 1.00 28.25  ? 412 GLN A N     1 
ATOM   3446 C  CA    . GLN A 1 422 ? 147.295 130.743 174.502 1.00 28.60  ? 412 GLN A CA    1 
ATOM   3447 C  C     . GLN A 1 422 ? 147.931 129.370 174.690 1.00 31.44  ? 412 GLN A C     1 
ATOM   3448 O  O     . GLN A 1 422 ? 147.730 128.464 173.871 1.00 37.66  ? 412 GLN A O     1 
ATOM   3449 C  CB    . GLN A 1 422 ? 148.315 131.747 173.981 1.00 25.67  ? 412 GLN A CB    1 
ATOM   3450 C  CG    . GLN A 1 422 ? 148.977 131.343 172.701 1.00 22.07  ? 412 GLN A CG    1 
ATOM   3451 C  CD    . GLN A 1 422 ? 149.948 132.379 172.225 1.00 21.53  ? 412 GLN A CD    1 
ATOM   3452 O  OE1   . GLN A 1 422 ? 149.832 133.554 172.563 1.00 21.62  ? 412 GLN A OE1   1 
ATOM   3453 N  NE2   . GLN A 1 422 ? 150.920 131.956 171.439 1.00 28.89  ? 412 GLN A NE2   1 
ATOM   3454 N  N     . LYS A 1 423 ? 148.685 129.192 175.776 1.00 28.53  ? 413 LYS A N     1 
ATOM   3455 C  CA    . LYS A 1 423 ? 149.271 127.886 176.065 1.00 31.94  ? 413 LYS A CA    1 
ATOM   3456 C  C     . LYS A 1 423 ? 148.197 126.831 176.303 1.00 40.07  ? 413 LYS A C     1 
ATOM   3457 O  O     . LYS A 1 423 ? 148.320 125.693 175.835 1.00 42.54  ? 413 LYS A O     1 
ATOM   3458 C  CB    . LYS A 1 423 ? 150.198 127.980 177.273 1.00 31.03  ? 413 LYS A CB    1 
ATOM   3459 C  CG    . LYS A 1 423 ? 150.889 126.676 177.610 1.00 33.57  ? 413 LYS A CG    1 
ATOM   3460 C  CD    . LYS A 1 423 ? 152.077 126.891 178.524 1.00 32.43  ? 413 LYS A CD    1 
ATOM   3461 C  CE    . LYS A 1 423 ? 152.940 125.646 178.591 1.00 35.79  ? 413 LYS A CE    1 
ATOM   3462 N  NZ    . LYS A 1 423 ? 154.198 125.884 179.341 1.00 50.07  ? 413 LYS A NZ    1 
ATOM   3463 N  N     . GLN A 1 424 ? 147.137 127.189 177.029 1.00 37.34  ? 414 GLN A N     1 
ATOM   3464 C  CA    . GLN A 1 424 ? 146.057 126.240 177.282 1.00 33.51  ? 414 GLN A CA    1 
ATOM   3465 C  C     . GLN A 1 424 ? 145.372 125.819 175.989 1.00 38.70  ? 414 GLN A C     1 
ATOM   3466 O  O     . GLN A 1 424 ? 145.090 124.632 175.783 1.00 45.49  ? 414 GLN A O     1 
ATOM   3467 C  CB    . GLN A 1 424 ? 145.049 126.852 178.250 1.00 33.35  ? 414 GLN A CB    1 
ATOM   3468 C  CG    . GLN A 1 424 ? 143.667 126.249 178.169 1.00 37.65  ? 414 GLN A CG    1 
ATOM   3469 C  CD    . GLN A 1 424 ? 142.765 126.714 179.289 1.00 39.02  ? 414 GLN A CD    1 
ATOM   3470 O  OE1   . GLN A 1 424 ? 143.224 127.299 180.267 1.00 35.42  ? 414 GLN A OE1   1 
ATOM   3471 N  NE2   . GLN A 1 424 ? 141.470 126.458 179.151 1.00 43.49  ? 414 GLN A NE2   1 
ATOM   3472 N  N     . LEU A 1 425 ? 145.103 126.777 175.101 1.00 36.08  ? 415 LEU A N     1 
ATOM   3473 C  CA    . LEU A 1 425 ? 144.458 126.461 173.832 1.00 30.56  ? 415 LEU A CA    1 
ATOM   3474 C  C     . LEU A 1 425 ? 145.351 125.594 172.962 1.00 32.50  ? 415 LEU A C     1 
ATOM   3475 O  O     . LEU A 1 425 ? 144.865 124.714 172.246 1.00 32.66  ? 415 LEU A O     1 
ATOM   3476 C  CB    . LEU A 1 425 ? 144.088 127.745 173.098 1.00 32.62  ? 415 LEU A CB    1 
ATOM   3477 C  CG    . LEU A 1 425 ? 142.952 128.575 173.686 1.00 33.99  ? 415 LEU A CG    1 
ATOM   3478 C  CD1   . LEU A 1 425 ? 143.139 130.012 173.290 1.00 30.65  ? 415 LEU A CD1   1 
ATOM   3479 C  CD2   . LEU A 1 425 ? 141.611 128.070 173.212 1.00 30.96  ? 415 LEU A CD2   1 
ATOM   3480 N  N     . LYS A 1 426 ? 146.662 125.841 172.994 1.00 37.16  ? 416 LYS A N     1 
ATOM   3481 C  CA    . LYS A 1 426 ? 147.578 124.970 172.267 1.00 35.58  ? 416 LYS A CA    1 
ATOM   3482 C  C     . LYS A 1 426 ? 147.563 123.560 172.838 1.00 46.21  ? 416 LYS A C     1 
ATOM   3483 O  O     . LYS A 1 426 ? 147.634 122.581 172.088 1.00 56.34  ? 416 LYS A O     1 
ATOM   3484 C  CB    . LYS A 1 426 ? 148.990 125.538 172.299 1.00 35.71  ? 416 LYS A CB    1 
ATOM   3485 C  CG    . LYS A 1 426 ? 149.929 124.864 171.325 1.00 39.79  ? 416 LYS A CG    1 
ATOM   3486 C  CD    . LYS A 1 426 ? 151.366 124.980 171.780 1.00 43.73  ? 416 LYS A CD    1 
ATOM   3487 C  CE    . LYS A 1 426 ? 152.302 124.313 170.803 1.00 37.21  ? 416 LYS A CE    1 
ATOM   3488 N  NZ    . LYS A 1 426 ? 153.693 124.296 171.316 1.00 45.08  ? 416 LYS A NZ    1 
ATOM   3489 N  N     . ASP A 1 427 ? 147.481 123.437 174.164 1.00 46.57  ? 417 ASP A N     1 
ATOM   3490 C  CA    . ASP A 1 427 ? 147.446 122.114 174.780 1.00 44.03  ? 417 ASP A CA    1 
ATOM   3491 C  C     . ASP A 1 427 ? 146.177 121.352 174.416 1.00 44.19  ? 417 ASP A C     1 
ATOM   3492 O  O     . ASP A 1 427 ? 146.237 120.158 174.108 1.00 46.27  ? 417 ASP A O     1 
ATOM   3493 C  CB    . ASP A 1 427 ? 147.580 122.232 176.296 1.00 45.94  ? 417 ASP A CB    1 
ATOM   3494 C  CG    . ASP A 1 427 ? 149.016 122.423 176.740 1.00 56.29  ? 417 ASP A CG    1 
ATOM   3495 O  OD1   . ASP A 1 427 ? 149.901 122.505 175.864 1.00 55.65  ? 417 ASP A OD1   1 
ATOM   3496 O  OD2   . ASP A 1 427 ? 149.261 122.488 177.962 1.00 56.94  ? 417 ASP A OD2   1 
ATOM   3497 N  N     . GLU A 1 428 ? 145.023 122.013 174.442 1.00 44.50  ? 418 GLU A N     1 
ATOM   3498 C  CA    . GLU A 1 428 ? 143.752 121.323 174.244 1.00 46.50  ? 418 GLU A CA    1 
ATOM   3499 C  C     . GLU A 1 428 ? 143.409 121.096 172.777 1.00 46.90  ? 418 GLU A C     1 
ATOM   3500 O  O     . GLU A 1 428 ? 142.310 120.612 172.485 1.00 47.50  ? 418 GLU A O     1 
ATOM   3501 C  CB    . GLU A 1 428 ? 142.614 122.089 174.922 1.00 46.31  ? 418 GLU A CB    1 
ATOM   3502 C  CG    . GLU A 1 428 ? 142.892 122.479 176.359 1.00 49.00  ? 418 GLU A CG    1 
ATOM   3503 C  CD    . GLU A 1 428 ? 141.653 122.959 177.083 1.00 57.59  ? 418 GLU A CD    1 
ATOM   3504 O  OE1   . GLU A 1 428 ? 140.534 122.642 176.628 1.00 54.50  ? 418 GLU A OE1   1 
ATOM   3505 O  OE2   . GLU A 1 428 ? 141.796 123.656 178.109 1.00 54.20  ? 418 GLU A OE2   1 
ATOM   3506 N  N     . ASN A 1 429 ? 144.315 121.433 171.857 1.00 45.74  ? 419 ASN A N     1 
ATOM   3507 C  CA    . ASN A 1 429 ? 144.119 121.216 170.421 1.00 44.03  ? 419 ASN A CA    1 
ATOM   3508 C  C     . ASN A 1 429 ? 142.885 121.945 169.893 1.00 46.18  ? 419 ASN A C     1 
ATOM   3509 O  O     . ASN A 1 429 ? 142.125 121.406 169.087 1.00 46.55  ? 419 ASN A O     1 
ATOM   3510 C  CB    . ASN A 1 429 ? 144.042 119.725 170.090 1.00 41.17  ? 419 ASN A CB    1 
ATOM   3511 C  CG    . ASN A 1 429 ? 145.335 118.993 170.384 1.00 54.32  ? 419 ASN A CG    1 
ATOM   3512 O  OD1   . ASN A 1 429 ? 146.398 119.365 169.887 1.00 59.93  ? 419 ASN A OD1   1 
ATOM   3513 N  ND2   . ASN A 1 429 ? 145.250 117.945 171.194 1.00 49.49  ? 419 ASN A ND2   1 
ATOM   3514 N  N     . ARG A 1 430 ? 142.680 123.181 170.350 1.00 46.25  ? 420 ARG A N     1 
ATOM   3515 C  CA    . ARG A 1 430 ? 141.626 124.049 169.823 1.00 39.91  ? 420 ARG A CA    1 
ATOM   3516 C  C     . ARG A 1 430 ? 142.286 125.055 168.884 1.00 38.84  ? 420 ARG A C     1 
ATOM   3517 O  O     . ARG A 1 430 ? 142.598 126.185 169.251 1.00 36.52  ? 420 ARG A O     1 
ATOM   3518 C  CB    . ARG A 1 430 ? 140.867 124.727 170.959 1.00 36.90  ? 420 ARG A CB    1 
ATOM   3519 C  CG    . ARG A 1 430 ? 140.252 123.753 171.940 1.00 41.25  ? 420 ARG A CG    1 
ATOM   3520 C  CD    . ARG A 1 430 ? 139.985 124.388 173.291 1.00 41.97  ? 420 ARG A CD    1 
ATOM   3521 N  NE    . ARG A 1 430 ? 139.253 125.642 173.183 1.00 40.80  ? 420 ARG A NE    1 
ATOM   3522 C  CZ    . ARG A 1 430 ? 138.720 126.286 174.212 1.00 48.21  ? 420 ARG A CZ    1 
ATOM   3523 N  NH1   . ARG A 1 430 ? 138.806 125.811 175.443 1.00 52.87  ? 420 ARG A NH1   1 
ATOM   3524 N  NH2   . ARG A 1 430 ? 138.086 127.434 174.002 1.00 46.19  ? 420 ARG A NH2   1 
ATOM   3525 N  N     . THR A 1 431 ? 142.478 124.622 167.635 1.00 34.69  ? 421 THR A N     1 
ATOM   3526 C  CA    . THR A 1 431 ? 143.386 125.313 166.724 1.00 35.07  ? 421 THR A CA    1 
ATOM   3527 C  C     . THR A 1 431 ? 142.890 126.703 166.345 1.00 35.00  ? 421 THR A C     1 
ATOM   3528 O  O     . THR A 1 431 ? 143.675 127.655 166.323 1.00 32.71  ? 421 THR A O     1 
ATOM   3529 C  CB    . THR A 1 431 ? 143.602 124.469 165.471 1.00 37.66  ? 421 THR A CB    1 
ATOM   3530 O  OG1   . THR A 1 431 ? 143.800 123.102 165.845 1.00 37.41  ? 421 THR A OG1   1 
ATOM   3531 C  CG2   . THR A 1 431 ? 144.814 124.961 164.701 1.00 39.03  ? 421 THR A CG2   1 
ATOM   3532 N  N     . LYS A 1 432 ? 141.604 126.842 166.019 1.00 34.96  ? 422 LYS A N     1 
ATOM   3533 C  CA    . LYS A 1 432 ? 141.103 128.122 165.525 1.00 34.26  ? 422 LYS A CA    1 
ATOM   3534 C  C     . LYS A 1 432 ? 141.226 129.211 166.584 1.00 35.32  ? 422 LYS A C     1 
ATOM   3535 O  O     . LYS A 1 432 ? 141.805 130.281 166.339 1.00 35.26  ? 422 LYS A O     1 
ATOM   3536 C  CB    . LYS A 1 432 ? 139.654 127.966 165.074 1.00 34.17  ? 422 LYS A CB    1 
ATOM   3537 C  CG    . LYS A 1 432 ? 139.491 127.159 163.805 1.00 33.31  ? 422 LYS A CG    1 
ATOM   3538 C  CD    . LYS A 1 432 ? 138.029 126.866 163.544 1.00 37.19  ? 422 LYS A CD    1 
ATOM   3539 C  CE    . LYS A 1 432 ? 137.857 125.645 162.664 1.00 42.47  ? 422 LYS A CE    1 
ATOM   3540 N  NZ    . LYS A 1 432 ? 136.451 125.163 162.677 1.00 48.05  ? 422 LYS A NZ    1 
ATOM   3541 N  N     . GLU A 1 433 ? 140.701 128.940 167.782 1.00 38.39  ? 423 GLU A N     1 
ATOM   3542 C  CA    . GLU A 1 433 ? 140.843 129.865 168.898 1.00 30.15  ? 423 GLU A CA    1 
ATOM   3543 C  C     . GLU A 1 433 ? 142.304 130.084 169.266 1.00 24.97  ? 423 GLU A C     1 
ATOM   3544 O  O     . GLU A 1 433 ? 142.681 131.192 169.662 1.00 33.77  ? 423 GLU A O     1 
ATOM   3545 C  CB    . GLU A 1 433 ? 140.058 129.342 170.097 1.00 29.70  ? 423 GLU A CB    1 
ATOM   3546 C  CG    . GLU A 1 433 ? 138.573 129.208 169.832 1.00 33.14  ? 423 GLU A CG    1 
ATOM   3547 C  CD    . GLU A 1 433 ? 137.881 128.275 170.803 1.00 43.89  ? 423 GLU A CD    1 
ATOM   3548 O  OE1   . GLU A 1 433 ? 138.237 127.080 170.838 1.00 48.06  ? 423 GLU A OE1   1 
ATOM   3549 O  OE2   . GLU A 1 433 ? 136.980 128.731 171.533 1.00 43.05  ? 423 GLU A OE2   1 
ATOM   3550 N  N     . TYR A 1 434 ? 143.136 129.051 169.133 1.00 19.98  ? 424 TYR A N     1 
ATOM   3551 C  CA    . TYR A 1 434 ? 144.548 129.187 169.466 1.00 23.77  ? 424 TYR A CA    1 
ATOM   3552 C  C     . TYR A 1 434 ? 145.244 130.174 168.535 1.00 22.01  ? 424 TYR A C     1 
ATOM   3553 O  O     . TYR A 1 434 ? 145.995 131.046 168.986 1.00 19.85  ? 424 TYR A O     1 
ATOM   3554 C  CB    . TYR A 1 434 ? 145.228 127.819 169.416 1.00 27.40  ? 424 TYR A CB    1 
ATOM   3555 C  CG    . TYR A 1 434 ? 146.733 127.882 169.353 1.00 25.48  ? 424 TYR A CG    1 
ATOM   3556 C  CD1   . TYR A 1 434 ? 147.473 128.322 170.439 1.00 26.99  ? 424 TYR A CD1   1 
ATOM   3557 C  CD2   . TYR A 1 434 ? 147.412 127.500 168.211 1.00 21.59  ? 424 TYR A CD2   1 
ATOM   3558 C  CE1   . TYR A 1 434 ? 148.844 128.385 170.386 1.00 26.76  ? 424 TYR A CE1   1 
ATOM   3559 C  CE2   . TYR A 1 434 ? 148.782 127.559 168.148 1.00 24.57  ? 424 TYR A CE2   1 
ATOM   3560 C  CZ    . TYR A 1 434 ? 149.492 128.000 169.239 1.00 30.92  ? 424 TYR A CZ    1 
ATOM   3561 O  OH    . TYR A 1 434 ? 150.859 128.058 169.181 1.00 37.33  ? 424 TYR A OH    1 
ATOM   3562 N  N     . ILE A 1 435 ? 145.010 130.049 167.228 1.00 22.81  ? 425 ILE A N     1 
ATOM   3563 C  CA    . ILE A 1 435 ? 145.600 130.988 166.279 1.00 22.49  ? 425 ILE A CA    1 
ATOM   3564 C  C     . ILE A 1 435 ? 145.054 132.385 166.515 1.00 24.18  ? 425 ILE A C     1 
ATOM   3565 O  O     . ILE A 1 435 ? 145.781 133.378 166.401 1.00 21.10  ? 425 ILE A O     1 
ATOM   3566 C  CB    . ILE A 1 435 ? 145.362 130.520 164.831 1.00 21.90  ? 425 ILE A CB    1 
ATOM   3567 C  CG1   . ILE A 1 435 ? 145.825 129.076 164.655 1.00 25.05  ? 425 ILE A CG1   1 
ATOM   3568 C  CG2   . ILE A 1 435 ? 146.084 131.427 163.845 1.00 20.86  ? 425 ILE A CG2   1 
ATOM   3569 C  CD1   . ILE A 1 435 ? 145.844 128.613 163.234 1.00 21.69  ? 425 ILE A CD1   1 
ATOM   3570 N  N     . TYR A 1 436 ? 143.768 132.485 166.858 1.00 30.10  ? 426 TYR A N     1 
ATOM   3571 C  CA    . TYR A 1 436 ? 143.189 133.784 167.184 1.00 20.17  ? 426 TYR A CA    1 
ATOM   3572 C  C     . TYR A 1 436 ? 143.946 134.459 168.326 1.00 20.46  ? 426 TYR A C     1 
ATOM   3573 O  O     . TYR A 1 436 ? 144.374 135.613 168.208 1.00 22.95  ? 426 TYR A O     1 
ATOM   3574 C  CB    . TYR A 1 436 ? 141.715 133.604 167.535 1.00 18.34  ? 426 TYR A CB    1 
ATOM   3575 C  CG    . TYR A 1 436 ? 141.077 134.779 168.231 1.00 22.91  ? 426 TYR A CG    1 
ATOM   3576 C  CD1   . TYR A 1 436 ? 141.143 136.053 167.692 1.00 22.07  ? 426 TYR A CD1   1 
ATOM   3577 C  CD2   . TYR A 1 436 ? 140.392 134.609 169.419 1.00 20.73  ? 426 TYR A CD2   1 
ATOM   3578 C  CE1   . TYR A 1 436 ? 140.557 137.119 168.325 1.00 21.34  ? 426 TYR A CE1   1 
ATOM   3579 C  CE2   . TYR A 1 436 ? 139.804 135.665 170.054 1.00 21.23  ? 426 TYR A CE2   1 
ATOM   3580 C  CZ    . TYR A 1 436 ? 139.890 136.918 169.507 1.00 24.77  ? 426 TYR A CZ    1 
ATOM   3581 O  OH    . TYR A 1 436 ? 139.299 137.978 170.150 1.00 33.31  ? 426 TYR A OH    1 
ATOM   3582 N  N     . VAL A 1 437 ? 144.133 133.746 169.435 1.00 20.12  ? 427 VAL A N     1 
ATOM   3583 C  CA    . VAL A 1 437 ? 144.785 134.341 170.598 1.00 19.08  ? 427 VAL A CA    1 
ATOM   3584 C  C     . VAL A 1 437 ? 146.254 134.634 170.311 1.00 20.91  ? 427 VAL A C     1 
ATOM   3585 O  O     . VAL A 1 437 ? 146.786 135.672 170.731 1.00 25.37  ? 427 VAL A O     1 
ATOM   3586 C  CB    . VAL A 1 437 ? 144.609 133.434 171.828 1.00 21.09  ? 427 VAL A CB    1 
ATOM   3587 C  CG1   . VAL A 1 437 ? 145.381 133.983 173.006 1.00 24.32  ? 427 VAL A CG1   1 
ATOM   3588 C  CG2   . VAL A 1 437 ? 143.148 133.321 172.177 1.00 17.24  ? 427 VAL A CG2   1 
ATOM   3589 N  N     . SER A 1 438 ? 146.936 133.733 169.597 1.00 19.61  ? 428 SER A N     1 
ATOM   3590 C  CA    . SER A 1 438 ? 148.322 133.987 169.220 1.00 15.16  ? 428 SER A CA    1 
ATOM   3591 C  C     . SER A 1 438 ? 148.441 135.250 168.391 1.00 17.23  ? 428 SER A C     1 
ATOM   3592 O  O     . SER A 1 438 ? 149.350 136.057 168.599 1.00 22.33  ? 428 SER A O     1 
ATOM   3593 C  CB    . SER A 1 438 ? 148.890 132.805 168.440 1.00 16.82  ? 428 SER A CB    1 
ATOM   3594 O  OG    . SER A 1 438 ? 149.360 131.793 169.306 1.00 28.88  ? 428 SER A OG    1 
ATOM   3595 N  N     . CYS A 1 439 ? 147.530 135.440 167.441 1.00 21.75  ? 429 CYS A N     1 
ATOM   3596 C  CA    . CYS A 1 439 ? 147.594 136.618 166.593 1.00 19.49  ? 429 CYS A CA    1 
ATOM   3597 C  C     . CYS A 1 439 ? 147.230 137.880 167.356 1.00 21.46  ? 429 CYS A C     1 
ATOM   3598 O  O     . CYS A 1 439 ? 147.761 138.945 167.053 1.00 23.09  ? 429 CYS A O     1 
ATOM   3599 C  CB    . CYS A 1 439 ? 146.692 136.424 165.379 1.00 19.64  ? 429 CYS A CB    1 
ATOM   3600 S  SG    . CYS A 1 439 ? 147.297 135.161 164.264 1.00 31.98  ? 429 CYS A SG    1 
ATOM   3601 N  N     . VAL A 1 440 ? 146.349 137.783 168.354 1.00 21.44  ? 430 VAL A N     1 
ATOM   3602 C  CA    . VAL A 1 440 ? 146.046 138.943 169.195 1.00 19.58  ? 430 VAL A CA    1 
ATOM   3603 C  C     . VAL A 1 440 ? 147.280 139.368 169.983 1.00 19.97  ? 430 VAL A C     1 
ATOM   3604 O  O     . VAL A 1 440 ? 147.669 140.546 169.988 1.00 24.59  ? 430 VAL A O     1 
ATOM   3605 C  CB    . VAL A 1 440 ? 144.866 138.632 170.130 1.00 20.95  ? 430 VAL A CB    1 
ATOM   3606 C  CG1   . VAL A 1 440 ? 144.732 139.707 171.191 1.00 21.48  ? 430 VAL A CG1   1 
ATOM   3607 C  CG2   . VAL A 1 440 ? 143.589 138.511 169.342 1.00 27.79  ? 430 VAL A CG2   1 
ATOM   3608 N  N     . ASN A 1 441 ? 147.916 138.405 170.656 1.00 18.39  ? 431 ASN A N     1 
ATOM   3609 C  CA    . ASN A 1 441 ? 149.128 138.692 171.418 1.00 13.84  ? 431 ASN A CA    1 
ATOM   3610 C  C     . ASN A 1 441 ? 150.214 139.263 170.521 1.00 16.91  ? 431 ASN A C     1 
ATOM   3611 O  O     . ASN A 1 441 ? 150.855 140.270 170.854 1.00 21.55  ? 431 ASN A O     1 
ATOM   3612 C  CB    . ASN A 1 441 ? 149.624 137.420 172.095 1.00 14.94  ? 431 ASN A CB    1 
ATOM   3613 C  CG    . ASN A 1 441 ? 148.907 137.124 173.379 1.00 19.70  ? 431 ASN A CG    1 
ATOM   3614 O  OD1   . ASN A 1 441 ? 148.619 138.022 174.164 1.00 18.66  ? 431 ASN A OD1   1 
ATOM   3615 N  ND2   . ASN A 1 441 ? 148.617 135.855 173.609 1.00 17.52  ? 431 ASN A ND2   1 
ATOM   3616 N  N     . LYS A 1 442 ? 150.431 138.627 169.371 1.00 15.94  ? 432 LYS A N     1 
ATOM   3617 C  CA    . LYS A 1 442 ? 151.465 139.069 168.452 1.00 15.00  ? 432 LYS A CA    1 
ATOM   3618 C  C     . LYS A 1 442 ? 151.131 140.426 167.861 1.00 20.04  ? 432 LYS A C     1 
ATOM   3619 O  O     . LYS A 1 442 ? 152.032 141.217 167.604 1.00 18.13  ? 432 LYS A O     1 
ATOM   3620 C  CB    . LYS A 1 442 ? 151.650 138.026 167.351 1.00 18.28  ? 432 LYS A CB    1 
ATOM   3621 C  CG    . LYS A 1 442 ? 152.766 138.318 166.359 1.00 21.74  ? 432 LYS A CG    1 
ATOM   3622 C  CD    . LYS A 1 442 ? 154.129 138.333 167.026 1.00 15.77  ? 432 LYS A CD    1 
ATOM   3623 C  CE    . LYS A 1 442 ? 154.495 136.962 167.553 1.00 17.35  ? 432 LYS A CE    1 
ATOM   3624 N  NZ    . LYS A 1 442 ? 154.738 135.978 166.476 1.00 12.99  ? 432 LYS A NZ    1 
ATOM   3625 N  N     . LEU A 1 443 ? 149.849 140.716 167.644 1.00 25.73  ? 433 LEU A N     1 
ATOM   3626 C  CA    . LEU A 1 443 ? 149.446 142.022 167.144 1.00 21.72  ? 433 LEU A CA    1 
ATOM   3627 C  C     . LEU A 1 443 ? 149.790 143.114 168.140 1.00 21.99  ? 433 LEU A C     1 
ATOM   3628 O  O     . LEU A 1 443 ? 150.318 144.165 167.764 1.00 22.29  ? 433 LEU A O     1 
ATOM   3629 C  CB    . LEU A 1 443 ? 147.947 142.016 166.848 1.00 15.70  ? 433 LEU A CB    1 
ATOM   3630 C  CG    . LEU A 1 443 ? 147.352 143.272 166.216 1.00 22.04  ? 433 LEU A CG    1 
ATOM   3631 C  CD1   . LEU A 1 443 ? 148.125 143.657 164.971 1.00 26.31  ? 433 LEU A CD1   1 
ATOM   3632 C  CD2   . LEU A 1 443 ? 145.891 143.070 165.902 1.00 22.55  ? 433 LEU A CD2   1 
ATOM   3633 N  N     . ARG A 1 444 ? 149.502 142.879 169.419 1.00 19.75  ? 434 ARG A N     1 
ATOM   3634 C  CA    . ARG A 1 444 ? 149.860 143.859 170.438 1.00 16.85  ? 434 ARG A CA    1 
ATOM   3635 C  C     . ARG A 1 444 ? 151.367 144.078 170.487 1.00 18.39  ? 434 ARG A C     1 
ATOM   3636 O  O     . ARG A 1 444 ? 151.850 145.220 170.416 1.00 27.20  ? 434 ARG A O     1 
ATOM   3637 C  CB    . ARG A 1 444 ? 149.326 143.406 171.791 1.00 20.97  ? 434 ARG A CB    1 
ATOM   3638 C  CG    . ARG A 1 444 ? 147.823 143.509 171.894 1.00 22.05  ? 434 ARG A CG    1 
ATOM   3639 C  CD    . ARG A 1 444 ? 147.301 142.838 173.138 1.00 27.29  ? 434 ARG A CD    1 
ATOM   3640 N  NE    . ARG A 1 444 ? 148.014 143.257 174.337 1.00 28.78  ? 434 ARG A NE    1 
ATOM   3641 C  CZ    . ARG A 1 444 ? 147.782 144.387 174.987 1.00 31.04  ? 434 ARG A CZ    1 
ATOM   3642 N  NH1   . ARG A 1 444 ? 146.890 145.261 174.555 1.00 34.16  ? 434 ARG A NH1   1 
ATOM   3643 N  NH2   . ARG A 1 444 ? 148.461 144.648 176.098 1.00 30.15  ? 434 ARG A NH2   1 
ATOM   3644 N  N     . ALA A 1 445 ? 152.131 142.986 170.571 1.00 18.20  ? 435 ALA A N     1 
ATOM   3645 C  CA    . ALA A 1 445 ? 153.586 143.112 170.614 1.00 17.72  ? 435 ALA A CA    1 
ATOM   3646 C  C     . ALA A 1 445 ? 154.123 143.804 169.368 1.00 18.89  ? 435 ALA A C     1 
ATOM   3647 O  O     . ALA A 1 445 ? 154.991 144.680 169.458 1.00 20.60  ? 435 ALA A O     1 
ATOM   3648 C  CB    . ALA A 1 445 ? 154.224 141.735 170.773 1.00 18.80  ? 435 ALA A CB    1 
ATOM   3649 N  N     . LYS A 1 446 ? 153.609 143.433 168.197 1.00 18.74  ? 436 LYS A N     1 
ATOM   3650 C  CA    . LYS A 1 446 ? 154.101 143.972 166.940 1.00 18.15  ? 436 LYS A CA    1 
ATOM   3651 C  C     . LYS A 1 446 ? 153.743 145.436 166.777 1.00 22.44  ? 436 LYS A C     1 
ATOM   3652 O  O     . LYS A 1 446 ? 154.502 146.186 166.164 1.00 25.09  ? 436 LYS A O     1 
ATOM   3653 C  CB    . LYS A 1 446 ? 153.550 143.158 165.771 1.00 19.15  ? 436 LYS A CB    1 
ATOM   3654 C  CG    . LYS A 1 446 ? 154.282 141.856 165.519 1.00 19.46  ? 436 LYS A CG    1 
ATOM   3655 C  CD    . LYS A 1 446 ? 155.711 142.108 165.098 1.00 21.46  ? 436 LYS A CD    1 
ATOM   3656 C  CE    . LYS A 1 446 ? 156.506 140.825 165.078 1.00 26.13  ? 436 LYS A CE    1 
ATOM   3657 N  NZ    . LYS A 1 446 ? 157.905 141.064 164.649 1.00 30.50  ? 436 LYS A NZ    1 
ATOM   3658 N  N     . TYR A 1 447 ? 152.596 145.870 167.302 1.00 24.71  ? 437 TYR A N     1 
ATOM   3659 C  CA    . TYR A 1 447 ? 152.293 147.293 167.247 1.00 23.01  ? 437 TYR A CA    1 
ATOM   3660 C  C     . TYR A 1 447 ? 153.218 148.083 168.162 1.00 23.63  ? 437 TYR A C     1 
ATOM   3661 O  O     . TYR A 1 447 ? 153.639 149.191 167.815 1.00 26.41  ? 437 TYR A O     1 
ATOM   3662 C  CB    . TYR A 1 447 ? 150.829 147.563 167.595 1.00 22.59  ? 437 TYR A CB    1 
ATOM   3663 C  CG    . TYR A 1 447 ? 150.564 149.046 167.667 1.00 32.11  ? 437 TYR A CG    1 
ATOM   3664 C  CD1   . TYR A 1 447 ? 150.863 149.872 166.589 1.00 34.54  ? 437 TYR A CD1   1 
ATOM   3665 C  CD2   . TYR A 1 447 ? 150.074 149.630 168.821 1.00 28.06  ? 437 TYR A CD2   1 
ATOM   3666 C  CE1   . TYR A 1 447 ? 150.661 151.228 166.649 1.00 29.06  ? 437 TYR A CE1   1 
ATOM   3667 C  CE2   . TYR A 1 447 ? 149.865 150.989 168.888 1.00 30.23  ? 437 TYR A CE2   1 
ATOM   3668 C  CZ    . TYR A 1 447 ? 150.161 151.782 167.801 1.00 31.65  ? 437 TYR A CZ    1 
ATOM   3669 O  OH    . TYR A 1 447 ? 149.952 153.138 167.865 1.00 36.98  ? 437 TYR A OH    1 
ATOM   3670 N  N     . VAL A 1 448 ? 153.555 147.535 169.331 1.00 23.53  ? 438 VAL A N     1 
ATOM   3671 C  CA    . VAL A 1 448 ? 154.549 148.216 170.163 1.00 20.12  ? 438 VAL A CA    1 
ATOM   3672 C  C     . VAL A 1 448 ? 155.881 148.315 169.427 1.00 22.47  ? 438 VAL A C     1 
ATOM   3673 O  O     . VAL A 1 448 ? 156.544 149.360 169.447 1.00 29.24  ? 438 VAL A O     1 
ATOM   3674 C  CB    . VAL A 1 448 ? 154.706 147.511 171.523 1.00 24.06  ? 438 VAL A CB    1 
ATOM   3675 C  CG1   . VAL A 1 448 ? 155.615 148.320 172.427 1.00 23.42  ? 438 VAL A CG1   1 
ATOM   3676 C  CG2   . VAL A 1 448 ? 153.365 147.325 172.177 1.00 23.12  ? 438 VAL A CG2   1 
ATOM   3677 N  N     . SER A 1 449 ? 156.287 147.234 168.758 1.00 20.99  ? 439 SER A N     1 
ATOM   3678 C  CA    . SER A 1 449 ? 157.528 147.254 167.984 1.00 20.25  ? 439 SER A CA    1 
ATOM   3679 C  C     . SER A 1 449 ? 157.469 148.275 166.853 1.00 24.98  ? 439 SER A C     1 
ATOM   3680 O  O     . SER A 1 449 ? 158.452 148.974 166.587 1.00 23.52  ? 439 SER A O     1 
ATOM   3681 C  CB    . SER A 1 449 ? 157.820 145.865 167.419 1.00 21.04  ? 439 SER A CB    1 
ATOM   3682 O  OG    . SER A 1 449 ? 157.626 144.858 168.392 1.00 25.55  ? 439 SER A OG    1 
ATOM   3683 N  N     . TYR A 1 450 ? 156.331 148.356 166.160 1.00 28.62  ? 440 TYR A N     1 
ATOM   3684 C  CA    . TYR A 1 450 ? 156.167 149.320 165.078 1.00 25.59  ? 440 TYR A CA    1 
ATOM   3685 C  C     . TYR A 1 450 ? 156.263 150.743 165.593 1.00 26.81  ? 440 TYR A C     1 
ATOM   3686 O  O     . TYR A 1 450 ? 156.866 151.605 164.947 1.00 30.01  ? 440 TYR A O     1 
ATOM   3687 C  CB    . TYR A 1 450 ? 154.823 149.099 164.379 1.00 26.97  ? 440 TYR A CB    1 
ATOM   3688 C  CG    . TYR A 1 450 ? 154.650 149.909 163.112 1.00 29.75  ? 440 TYR A CG    1 
ATOM   3689 C  CD1   . TYR A 1 450 ? 154.129 151.191 163.150 1.00 29.71  ? 440 TYR A CD1   1 
ATOM   3690 C  CD2   . TYR A 1 450 ? 155.014 149.391 161.881 1.00 32.78  ? 440 TYR A CD2   1 
ATOM   3691 C  CE1   . TYR A 1 450 ? 153.981 151.931 162.005 1.00 27.97  ? 440 TYR A CE1   1 
ATOM   3692 C  CE2   . TYR A 1 450 ? 154.864 150.125 160.730 1.00 31.22  ? 440 TYR A CE2   1 
ATOM   3693 C  CZ    . TYR A 1 450 ? 154.349 151.394 160.799 1.00 30.53  ? 440 TYR A CZ    1 
ATOM   3694 O  OH    . TYR A 1 450 ? 154.201 152.130 159.651 1.00 37.33  ? 440 TYR A OH    1 
ATOM   3695 N  N     . PHE A 1 451 ? 155.658 151.014 166.749 1.00 28.05  ? 441 PHE A N     1 
ATOM   3696 C  CA    . PHE A 1 451 ? 155.764 152.338 167.345 1.00 24.29  ? 441 PHE A CA    1 
ATOM   3697 C  C     . PHE A 1 451 ? 157.210 152.670 167.694 1.00 26.83  ? 441 PHE A C     1 
ATOM   3698 O  O     . PHE A 1 451 ? 157.682 153.779 167.419 1.00 29.79  ? 441 PHE A O     1 
ATOM   3699 C  CB    . PHE A 1 451 ? 154.863 152.421 168.578 1.00 24.67  ? 441 PHE A CB    1 
ATOM   3700 C  CG    . PHE A 1 451 ? 154.883 153.756 169.253 1.00 28.29  ? 441 PHE A CG    1 
ATOM   3701 C  CD1   . PHE A 1 451 ? 154.254 154.842 168.680 1.00 28.66  ? 441 PHE A CD1   1 
ATOM   3702 C  CD2   . PHE A 1 451 ? 155.533 153.926 170.459 1.00 26.21  ? 441 PHE A CD2   1 
ATOM   3703 C  CE1   . PHE A 1 451 ? 154.278 156.071 169.293 1.00 29.62  ? 441 PHE A CE1   1 
ATOM   3704 C  CE2   . PHE A 1 451 ? 155.561 155.150 171.074 1.00 30.09  ? 441 PHE A CE2   1 
ATOM   3705 C  CZ    . PHE A 1 451 ? 154.933 156.225 170.492 1.00 31.90  ? 441 PHE A CZ    1 
ATOM   3706 N  N     . ILE A 1 452 ? 157.936 151.714 168.278 1.00 28.27  ? 442 ILE A N     1 
ATOM   3707 C  CA    . ILE A 1 452 ? 159.339 151.948 168.620 1.00 27.22  ? 442 ILE A CA    1 
ATOM   3708 C  C     . ILE A 1 452 ? 160.155 152.238 167.365 1.00 28.45  ? 442 ILE A C     1 
ATOM   3709 O  O     . ILE A 1 452 ? 160.977 153.162 167.332 1.00 30.83  ? 442 ILE A O     1 
ATOM   3710 C  CB    . ILE A 1 452 ? 159.914 150.746 169.388 1.00 30.54  ? 442 ILE A CB    1 
ATOM   3711 C  CG1   . ILE A 1 452 ? 159.342 150.678 170.797 1.00 31.83  ? 442 ILE A CG1   1 
ATOM   3712 C  CG2   . ILE A 1 452 ? 161.427 150.827 169.449 1.00 28.46  ? 442 ILE A CG2   1 
ATOM   3713 C  CD1   . ILE A 1 452 ? 159.762 149.447 171.534 1.00 29.39  ? 442 ILE A CD1   1 
ATOM   3714 N  N     . LEU A 1 453 ? 159.940 151.446 166.316 1.00 29.46  ? 443 LEU A N     1 
ATOM   3715 C  CA    . LEU A 1 453 ? 160.693 151.610 165.078 1.00 26.07  ? 443 LEU A CA    1 
ATOM   3716 C  C     . LEU A 1 453 ? 160.377 152.939 164.401 1.00 29.99  ? 443 LEU A C     1 
ATOM   3717 O  O     . LEU A 1 453 ? 161.279 153.608 163.882 1.00 29.04  ? 443 LEU A O     1 
ATOM   3718 C  CB    . LEU A 1 453 ? 160.396 150.442 164.143 1.00 27.75  ? 443 LEU A CB    1 
ATOM   3719 C  CG    . LEU A 1 453 ? 161.211 149.173 164.387 1.00 29.32  ? 443 LEU A CG    1 
ATOM   3720 C  CD1   . LEU A 1 453 ? 160.671 148.035 163.559 1.00 28.14  ? 443 LEU A CD1   1 
ATOM   3721 C  CD2   . LEU A 1 453 ? 162.672 149.411 164.068 1.00 32.78  ? 443 LEU A CD2   1 
ATOM   3722 N  N     . LYS A 1 454 ? 159.102 153.337 164.396 1.00 32.42  ? 444 LYS A N     1 
ATOM   3723 C  CA    . LYS A 1 454 ? 158.706 154.609 163.800 1.00 29.51  ? 444 LYS A CA    1 
ATOM   3724 C  C     . LYS A 1 454 ? 159.294 155.786 164.568 1.00 32.02  ? 444 LYS A C     1 
ATOM   3725 O  O     . LYS A 1 454 ? 159.761 156.763 163.965 1.00 36.83  ? 444 LYS A O     1 
ATOM   3726 C  CB    . LYS A 1 454 ? 157.179 154.692 163.749 1.00 31.67  ? 444 LYS A CB    1 
ATOM   3727 C  CG    . LYS A 1 454 ? 156.626 155.945 163.106 1.00 37.12  ? 444 LYS A CG    1 
ATOM   3728 C  CD    . LYS A 1 454 ? 157.023 156.055 161.647 1.00 35.60  ? 444 LYS A CD    1 
ATOM   3729 C  CE    . LYS A 1 454 ? 156.385 154.975 160.811 1.00 31.51  ? 444 LYS A CE    1 
ATOM   3730 N  NZ    . LYS A 1 454 ? 154.920 155.180 160.716 1.00 40.09  ? 444 LYS A NZ    1 
ATOM   3731 N  N     . GLU A 1 455 ? 159.288 155.711 165.900 1.00 31.90  ? 445 GLU A N     1 
ATOM   3732 C  CA    . GLU A 1 455 ? 159.887 156.779 166.690 1.00 31.39  ? 445 GLU A CA    1 
ATOM   3733 C  C     . GLU A 1 455 ? 161.388 156.860 166.458 1.00 32.41  ? 445 GLU A C     1 
ATOM   3734 O  O     . GLU A 1 455 ? 161.955 157.955 166.403 1.00 41.82  ? 445 GLU A O     1 
ATOM   3735 C  CB    . GLU A 1 455 ? 159.576 156.580 168.170 1.00 31.33  ? 445 GLU A CB    1 
ATOM   3736 C  CG    . GLU A 1 455 ? 158.103 156.674 168.496 1.00 36.36  ? 445 GLU A CG    1 
ATOM   3737 C  CD    . GLU A 1 455 ? 157.528 158.031 168.176 1.00 43.28  ? 445 GLU A CD    1 
ATOM   3738 O  OE1   . GLU A 1 455 ? 157.995 159.026 168.761 1.00 51.65  ? 445 GLU A OE1   1 
ATOM   3739 O  OE2   . GLU A 1 455 ? 156.611 158.106 167.334 1.00 45.07  ? 445 GLU A OE2   1 
ATOM   3740 N  N     . LYS A 1 456 ? 162.054 155.712 166.329 1.00 31.54  ? 446 LYS A N     1 
ATOM   3741 C  CA    . LYS A 1 456 ? 163.477 155.743 166.016 1.00 32.49  ? 446 LYS A CA    1 
ATOM   3742 C  C     . LYS A 1 456 ? 163.721 156.339 164.640 1.00 36.06  ? 446 LYS A C     1 
ATOM   3743 O  O     . LYS A 1 456 ? 164.720 157.030 164.426 1.00 41.52  ? 446 LYS A O     1 
ATOM   3744 C  CB    . LYS A 1 456 ? 164.080 154.344 166.107 1.00 36.40  ? 446 LYS A CB    1 
ATOM   3745 C  CG    . LYS A 1 456 ? 165.597 154.355 166.177 1.00 36.26  ? 446 LYS A CG    1 
ATOM   3746 C  CD    . LYS A 1 456 ? 166.067 154.886 167.513 1.00 39.87  ? 446 LYS A CD    1 
ATOM   3747 C  CE    . LYS A 1 456 ? 167.573 154.982 167.563 1.00 41.90  ? 446 LYS A CE    1 
ATOM   3748 N  NZ    . LYS A 1 456 ? 168.040 155.482 168.882 1.00 39.18  ? 446 LYS A NZ    1 
ATOM   3749 N  N     . TYR A 1 457 ? 162.821 156.075 163.690 1.00 36.01  ? 447 TYR A N     1 
ATOM   3750 C  CA    . TYR A 1 457 ? 162.935 156.695 162.374 1.00 34.99  ? 447 TYR A CA    1 
ATOM   3751 C  C     . TYR A 1 457 ? 162.841 158.210 162.473 1.00 37.15  ? 447 TYR A C     1 
ATOM   3752 O  O     . TYR A 1 457 ? 163.629 158.930 161.849 1.00 38.98  ? 447 TYR A O     1 
ATOM   3753 C  CB    . TYR A 1 457 ? 161.852 156.151 161.443 1.00 34.24  ? 447 TYR A CB    1 
ATOM   3754 C  CG    . TYR A 1 457 ? 161.927 156.699 160.037 1.00 38.45  ? 447 TYR A CG    1 
ATOM   3755 C  CD1   . TYR A 1 457 ? 162.805 156.163 159.107 1.00 42.72  ? 447 TYR A CD1   1 
ATOM   3756 C  CD2   . TYR A 1 457 ? 161.123 157.754 159.639 1.00 39.55  ? 447 TYR A CD2   1 
ATOM   3757 C  CE1   . TYR A 1 457 ? 162.879 156.663 157.828 1.00 41.47  ? 447 TYR A CE1   1 
ATOM   3758 C  CE2   . TYR A 1 457 ? 161.193 158.257 158.362 1.00 40.14  ? 447 TYR A CE2   1 
ATOM   3759 C  CZ    . TYR A 1 457 ? 162.071 157.708 157.462 1.00 41.33  ? 447 TYR A CZ    1 
ATOM   3760 O  OH    . TYR A 1 457 ? 162.139 158.210 156.186 1.00 45.20  ? 447 TYR A OH    1 
ATOM   3761 N  N     . TYR A 1 458 ? 161.884 158.712 163.258 1.00 36.44  ? 448 TYR A N     1 
ATOM   3762 C  CA    . TYR A 1 458 ? 161.758 160.158 163.435 1.00 36.92  ? 448 TYR A CA    1 
ATOM   3763 C  C     . TYR A 1 458 ? 162.996 160.746 164.102 1.00 36.39  ? 448 TYR A C     1 
ATOM   3764 O  O     . TYR A 1 458 ? 163.502 161.792 163.678 1.00 42.60  ? 448 TYR A O     1 
ATOM   3765 C  CB    . TYR A 1 458 ? 160.514 160.492 164.257 1.00 33.41  ? 448 TYR A CB    1 
ATOM   3766 C  CG    . TYR A 1 458 ? 159.201 160.105 163.621 1.00 35.87  ? 448 TYR A CG    1 
ATOM   3767 C  CD1   . TYR A 1 458 ? 159.088 159.931 162.254 1.00 35.50  ? 448 TYR A CD1   1 
ATOM   3768 C  CD2   . TYR A 1 458 ? 158.070 159.918 164.397 1.00 37.76  ? 448 TYR A CD2   1 
ATOM   3769 C  CE1   . TYR A 1 458 ? 157.890 159.577 161.679 1.00 32.85  ? 448 TYR A CE1   1 
ATOM   3770 C  CE2   . TYR A 1 458 ? 156.866 159.564 163.831 1.00 33.72  ? 448 TYR A CE2   1 
ATOM   3771 C  CZ    . TYR A 1 458 ? 156.782 159.397 162.474 1.00 33.12  ? 448 TYR A CZ    1 
ATOM   3772 O  OH    . TYR A 1 458 ? 155.581 159.047 161.912 1.00 38.05  ? 448 TYR A OH    1 
ATOM   3773 N  N     . GLU A 1 459 ? 163.497 160.089 165.149 1.00 36.40  ? 449 GLU A N     1 
ATOM   3774 C  CA    . GLU A 1 459 ? 164.696 160.576 165.826 1.00 38.04  ? 449 GLU A CA    1 
ATOM   3775 C  C     . GLU A 1 459 ? 165.886 160.612 164.881 1.00 41.68  ? 449 GLU A C     1 
ATOM   3776 O  O     . GLU A 1 459 ? 166.650 161.584 164.866 1.00 43.49  ? 449 GLU A O     1 
ATOM   3777 C  CB    . GLU A 1 459 ? 165.023 159.696 167.030 1.00 43.16  ? 449 GLU A CB    1 
ATOM   3778 C  CG    . GLU A 1 459 ? 163.991 159.703 168.134 1.00 49.08  ? 449 GLU A CG    1 
ATOM   3779 C  CD    . GLU A 1 459 ? 164.239 158.606 169.153 1.00 58.31  ? 449 GLU A CD    1 
ATOM   3780 O  OE1   . GLU A 1 459 ? 165.387 158.120 169.237 1.00 54.57  ? 449 GLU A OE1   1 
ATOM   3781 O  OE2   . GLU A 1 459 ? 163.287 158.226 169.866 1.00 62.77  ? 449 GLU A OE2   1 
ATOM   3782 N  N     . LYS A 1 460 ? 166.069 159.552 164.094 1.00 39.72  ? 450 LYS A N     1 
ATOM   3783 C  CA    . LYS A 1 460 ? 167.209 159.486 163.193 1.00 41.85  ? 450 LYS A CA    1 
ATOM   3784 C  C     . LYS A 1 460 ? 167.105 160.530 162.093 1.00 47.80  ? 450 LYS A C     1 
ATOM   3785 O  O     . LYS A 1 460 ? 168.114 161.134 161.710 1.00 47.24  ? 450 LYS A O     1 
ATOM   3786 C  CB    . LYS A 1 460 ? 167.323 158.082 162.610 1.00 45.64  ? 450 LYS A CB    1 
ATOM   3787 C  CG    . LYS A 1 460 ? 167.965 157.093 163.560 1.00 53.56  ? 450 LYS A CG    1 
ATOM   3788 C  CD    . LYS A 1 460 ? 169.296 157.622 164.064 1.00 47.53  ? 450 LYS A CD    1 
ATOM   3789 C  CE    . LYS A 1 460 ? 169.874 156.731 165.140 1.00 50.20  ? 450 LYS A CE    1 
ATOM   3790 N  NZ    . LYS A 1 460 ? 171.283 157.089 165.446 1.00 47.90  ? 450 LYS A NZ    1 
ATOM   3791 N  N     . GLN A 1 461 ? 165.895 160.764 161.576 1.00 47.94  ? 451 GLN A N     1 
ATOM   3792 C  CA    . GLN A 1 461 ? 165.720 161.814 160.580 1.00 43.83  ? 451 GLN A CA    1 
ATOM   3793 C  C     . GLN A 1 461 ? 166.033 163.182 161.163 1.00 45.13  ? 451 GLN A C     1 
ATOM   3794 O  O     . GLN A 1 461 ? 166.705 163.998 160.522 1.00 47.54  ? 451 GLN A O     1 
ATOM   3795 C  CB    . GLN A 1 461 ? 164.302 161.793 160.025 1.00 40.02  ? 451 GLN A CB    1 
ATOM   3796 C  CG    . GLN A 1 461 ? 164.128 162.694 158.827 1.00 40.74  ? 451 GLN A CG    1 
ATOM   3797 C  CD    . GLN A 1 461 ? 162.798 162.508 158.152 1.00 38.12  ? 451 GLN A CD    1 
ATOM   3798 O  OE1   . GLN A 1 461 ? 162.497 163.172 157.164 1.00 35.42  ? 451 GLN A OE1   1 
ATOM   3799 N  NE2   . GLN A 1 461 ? 161.986 161.605 158.683 1.00 36.78  ? 451 GLN A NE2   1 
ATOM   3800 N  N     . LYS A 1 462 ? 165.555 163.450 162.379 1.00 43.56  ? 452 LYS A N     1 
ATOM   3801 C  CA    . LYS A 1 462 ? 165.837 164.731 163.018 1.00 44.00  ? 452 LYS A CA    1 
ATOM   3802 C  C     . LYS A 1 462 ? 167.332 164.923 163.229 1.00 48.75  ? 452 LYS A C     1 
ATOM   3803 O  O     . LYS A 1 462 ? 167.878 165.996 162.947 1.00 51.50  ? 452 LYS A O     1 
ATOM   3804 C  CB    . LYS A 1 462 ? 165.086 164.815 164.345 1.00 43.30  ? 452 LYS A CB    1 
ATOM   3805 C  CG    . LYS A 1 462 ? 165.350 166.067 165.151 1.00 44.45  ? 452 LYS A CG    1 
ATOM   3806 C  CD    . LYS A 1 462 ? 164.470 166.106 166.385 1.00 46.64  ? 452 LYS A CD    1 
ATOM   3807 C  CE    . LYS A 1 462 ? 164.569 167.441 167.094 1.00 48.40  ? 452 LYS A CE    1 
ATOM   3808 N  NZ    . LYS A 1 462 ? 163.622 167.527 168.232 1.00 42.10  ? 452 LYS A NZ    1 
ATOM   3809 N  N     . GLU A 1 463 ? 168.015 163.887 163.715 1.00 52.00  ? 453 GLU A N     1 
ATOM   3810 C  CA    . GLU A 1 463 ? 169.447 163.998 163.956 1.00 49.49  ? 453 GLU A CA    1 
ATOM   3811 C  C     . GLU A 1 463 ? 170.208 164.201 162.655 1.00 54.46  ? 453 GLU A C     1 
ATOM   3812 O  O     . GLU A 1 463 ? 171.139 165.012 162.593 1.00 59.93  ? 453 GLU A O     1 
ATOM   3813 C  CB    . GLU A 1 463 ? 169.949 162.758 164.690 1.00 54.49  ? 453 GLU A CB    1 
ATOM   3814 C  CG    . GLU A 1 463 ? 171.217 162.992 165.486 1.00 61.57  ? 453 GLU A CG    1 
ATOM   3815 C  CD    . GLU A 1 463 ? 171.769 161.720 166.089 1.00 75.50  ? 453 GLU A CD    1 
ATOM   3816 O  OE1   . GLU A 1 463 ? 171.161 160.650 165.883 1.00 77.12  ? 453 GLU A OE1   1 
ATOM   3817 O  OE2   . GLU A 1 463 ? 172.813 161.789 166.770 1.00 85.04  ? 453 GLU A OE2   1 
ATOM   3818 N  N     . TYR A 1 464 ? 169.822 163.481 161.598 1.00 54.24  ? 454 TYR A N     1 
ATOM   3819 C  CA    . TYR A 1 464 ? 170.500 163.644 160.318 1.00 55.99  ? 454 TYR A CA    1 
ATOM   3820 C  C     . TYR A 1 464 ? 170.285 165.036 159.743 1.00 59.07  ? 454 TYR A C     1 
ATOM   3821 O  O     . TYR A 1 464 ? 171.224 165.644 159.222 1.00 62.22  ? 454 TYR A O     1 
ATOM   3822 C  CB    . TYR A 1 464 ? 170.028 162.591 159.321 1.00 51.01  ? 454 TYR A CB    1 
ATOM   3823 C  CG    . TYR A 1 464 ? 170.638 162.782 157.953 1.00 57.76  ? 454 TYR A CG    1 
ATOM   3824 C  CD1   . TYR A 1 464 ? 171.983 162.533 157.733 1.00 57.72  ? 454 TYR A CD1   1 
ATOM   3825 C  CD2   . TYR A 1 464 ? 169.877 163.233 156.888 1.00 57.83  ? 454 TYR A CD2   1 
ATOM   3826 C  CE1   . TYR A 1 464 ? 172.546 162.711 156.493 1.00 52.59  ? 454 TYR A CE1   1 
ATOM   3827 C  CE2   . TYR A 1 464 ? 170.434 163.416 155.646 1.00 60.68  ? 454 TYR A CE2   1 
ATOM   3828 C  CZ    . TYR A 1 464 ? 171.768 163.154 155.455 1.00 60.70  ? 454 TYR A CZ    1 
ATOM   3829 O  OH    . TYR A 1 464 ? 172.327 163.334 154.214 1.00 69.58  ? 454 TYR A OH    1 
ATOM   3830 N  N     . ASP A 1 465 ? 169.060 165.556 159.817 1.00 55.25  ? 455 ASP A N     1 
ATOM   3831 C  CA    . ASP A 1 465 ? 168.773 166.860 159.236 1.00 51.97  ? 455 ASP A CA    1 
ATOM   3832 C  C     . ASP A 1 465 ? 169.212 168.020 160.116 1.00 55.60  ? 455 ASP A C     1 
ATOM   3833 O  O     . ASP A 1 465 ? 169.183 169.164 159.654 1.00 60.89  ? 455 ASP A O     1 
ATOM   3834 C  CB    . ASP A 1 465 ? 167.281 166.990 158.926 1.00 52.87  ? 455 ASP A CB    1 
ATOM   3835 C  CG    . ASP A 1 465 ? 166.861 166.174 157.717 1.00 63.41  ? 455 ASP A CG    1 
ATOM   3836 O  OD1   . ASP A 1 465 ? 167.690 165.990 156.802 1.00 68.78  ? 455 ASP A OD1   1 
ATOM   3837 O  OD2   . ASP A 1 465 ? 165.696 165.731 157.670 1.00 59.13  ? 455 ASP A OD2   1 
ATOM   3838 N  N     . ILE A 1 466 ? 169.597 167.768 161.364 1.00 56.40  ? 456 ILE A N     1 
ATOM   3839 C  CA    . ILE A 1 466 ? 170.248 168.808 162.157 1.00 55.98  ? 456 ILE A CA    1 
ATOM   3840 C  C     . ILE A 1 466 ? 171.761 168.770 161.988 1.00 61.73  ? 456 ILE A C     1 
ATOM   3841 O  O     . ILE A 1 466 ? 172.406 169.817 161.921 1.00 64.57  ? 456 ILE A O     1 
ATOM   3842 C  CB    . ILE A 1 466 ? 169.838 168.700 163.639 1.00 54.59  ? 456 ILE A CB    1 
ATOM   3843 C  CG1   . ILE A 1 466 ? 168.345 168.980 163.796 1.00 54.17  ? 456 ILE A CG1   1 
ATOM   3844 C  CG2   . ILE A 1 466 ? 170.646 169.652 164.496 1.00 53.21  ? 456 ILE A CG2   1 
ATOM   3845 C  CD1   . ILE A 1 466 ? 167.811 168.665 165.165 1.00 58.22  ? 456 ILE A CD1   1 
ATOM   3846 N  N     . GLU A 1 467 ? 172.359 167.581 161.908 1.00 67.21  ? 457 GLU A N     1 
ATOM   3847 C  CA    . GLU A 1 467 ? 173.792 167.510 161.654 1.00 72.86  ? 457 GLU A CA    1 
ATOM   3848 C  C     . GLU A 1 467 ? 174.123 167.931 160.228 1.00 73.85  ? 457 GLU A C     1 
ATOM   3849 O  O     . GLU A 1 467 ? 175.216 168.450 159.973 1.00 75.33  ? 457 GLU A O     1 
ATOM   3850 C  CB    . GLU A 1 467 ? 174.305 166.098 161.935 1.00 78.44  ? 457 GLU A CB    1 
ATOM   3851 C  CG    . GLU A 1 467 ? 175.822 165.975 161.945 1.00 89.43  ? 457 GLU A CG    1 
ATOM   3852 C  CD    . GLU A 1 467 ? 176.296 164.555 162.190 1.00 99.09  ? 457 GLU A CD    1 
ATOM   3853 O  OE1   . GLU A 1 467 ? 175.443 163.670 162.408 1.00 99.86  ? 457 GLU A OE1   1 
ATOM   3854 O  OE2   . GLU A 1 467 ? 177.522 164.324 162.161 1.00 101.34 ? 457 GLU A OE2   1 
ATOM   3855 N  N     . MET A 1 468 ? 173.196 167.716 159.292 1.00 70.44  ? 458 MET A N     1 
ATOM   3856 C  CA    . MET A 1 468 ? 173.397 168.162 157.919 1.00 72.91  ? 458 MET A CA    1 
ATOM   3857 C  C     . MET A 1 468 ? 173.450 169.681 157.838 1.00 81.14  ? 458 MET A C     1 
ATOM   3858 O  O     . MET A 1 468 ? 174.319 170.246 157.162 1.00 84.07  ? 458 MET A O     1 
ATOM   3859 C  CB    . MET A 1 468 ? 172.284 167.613 157.029 1.00 67.68  ? 458 MET A CB    1 
ATOM   3860 C  CG    . MET A 1 468 ? 172.590 167.633 155.544 1.00 73.99  ? 458 MET A CG    1 
ATOM   3861 S  SD    . MET A 1 468 ? 174.094 166.748 155.100 1.00 78.67  ? 458 MET A SD    1 
ATOM   3862 C  CE    . MET A 1 468 ? 173.824 166.497 153.348 1.00 71.37  ? 458 MET A CE    1 
ATOM   3863 N  N     . GLY A 1 469 ? 172.535 170.359 158.525 1.00 77.66  ? 459 GLY A N     1 
ATOM   3864 C  CA    . GLY A 1 469 ? 172.555 171.806 158.585 1.00 76.30  ? 459 GLY A CA    1 
ATOM   3865 C  C     . GLY A 1 469 ? 172.199 172.482 157.278 1.00 83.44  ? 459 GLY A C     1 
ATOM   3866 O  O     . GLY A 1 469 ? 173.046 173.124 156.653 1.00 89.82  ? 459 GLY A O     1 
ATOM   3867 N  N     . PHE A 1 470 ? 170.949 172.338 156.850 1.00 79.95  ? 460 PHE A N     1 
ATOM   3868 C  CA    . PHE A 1 470 ? 170.497 173.016 155.645 1.00 78.30  ? 460 PHE A CA    1 
ATOM   3869 C  C     . PHE A 1 470 ? 170.439 174.520 155.871 1.00 77.63  ? 460 PHE A C     1 
ATOM   3870 O  O     . PHE A 1 470 ? 169.981 174.991 156.914 1.00 75.65  ? 460 PHE A O     1 
ATOM   3871 C  CB    . PHE A 1 470 ? 169.125 172.498 155.226 1.00 75.71  ? 460 PHE A CB    1 
ATOM   3872 C  CG    . PHE A 1 470 ? 169.067 171.011 155.048 1.00 75.25  ? 460 PHE A CG    1 
ATOM   3873 C  CD1   . PHE A 1 470 ? 169.830 170.388 154.080 1.00 77.48  ? 460 PHE A CD1   1 
ATOM   3874 C  CD2   . PHE A 1 470 ? 168.241 170.237 155.840 1.00 66.79  ? 460 PHE A CD2   1 
ATOM   3875 C  CE1   . PHE A 1 470 ? 169.773 169.022 153.911 1.00 75.04  ? 460 PHE A CE1   1 
ATOM   3876 C  CE2   . PHE A 1 470 ? 168.181 168.872 155.673 1.00 64.73  ? 460 PHE A CE2   1 
ATOM   3877 C  CZ    . PHE A 1 470 ? 168.949 168.265 154.710 1.00 68.09  ? 460 PHE A CZ    1 
ATOM   3878 N  N     . VAL A 1 471 ? 170.919 175.276 154.888 1.00 83.80  ? 461 VAL A N     1 
ATOM   3879 C  CA    . VAL A 1 471 ? 170.842 176.732 154.896 1.00 87.45  ? 461 VAL A CA    1 
ATOM   3880 C  C     . VAL A 1 471 ? 170.252 177.170 153.565 1.00 91.10  ? 461 VAL A C     1 
ATOM   3881 O  O     . VAL A 1 471 ? 170.811 176.866 152.505 1.00 91.82  ? 461 VAL A O     1 
ATOM   3882 C  CB    . VAL A 1 471 ? 172.214 177.388 155.119 1.00 87.29  ? 461 VAL A CB    1 
ATOM   3883 C  CG1   . VAL A 1 471 ? 172.083 178.900 155.088 1.00 84.15  ? 461 VAL A CG1   1 
ATOM   3884 C  CG2   . VAL A 1 471 ? 172.815 176.933 156.437 1.00 86.95  ? 461 VAL A CG2   1 
ATOM   3885 N  N     . ASP A 1 472 ? 169.133 177.883 153.616 1.00 91.87  ? 462 ASP A N     1 
ATOM   3886 C  CA    . ASP A 1 472 ? 168.423 178.312 152.421 1.00 93.63  ? 462 ASP A CA    1 
ATOM   3887 C  C     . ASP A 1 472 ? 168.479 179.828 152.306 1.00 100.03 ? 462 ASP A C     1 
ATOM   3888 O  O     . ASP A 1 472 ? 168.069 180.541 153.228 1.00 99.17  ? 462 ASP A O     1 
ATOM   3889 C  CB    . ASP A 1 472 ? 166.970 177.840 152.455 1.00 92.35  ? 462 ASP A CB    1 
ATOM   3890 C  CG    . ASP A 1 472 ? 166.847 176.341 152.321 1.00 93.37  ? 462 ASP A CG    1 
ATOM   3891 O  OD1   . ASP A 1 472 ? 167.724 175.732 151.679 1.00 92.94  ? 462 ASP A OD1   1 
ATOM   3892 O  OD2   . ASP A 1 472 ? 165.878 175.772 152.859 1.00 95.89  ? 462 ASP A OD2   1 
ATOM   3893 N  N     . ASP A 1 473 ? 168.997 180.316 151.176 1.00 101.90 ? 463 ASP A N     1 
ATOM   3894 C  CA    . ASP A 1 473 ? 168.987 181.752 150.920 1.00 101.30 ? 463 ASP A CA    1 
ATOM   3895 C  C     . ASP A 1 473 ? 167.562 182.267 150.770 1.00 97.82  ? 463 ASP A C     1 
ATOM   3896 O  O     . ASP A 1 473 ? 167.224 183.345 151.273 1.00 95.25  ? 463 ASP A O     1 
ATOM   3897 C  CB    . ASP A 1 473 ? 169.810 182.068 149.671 1.00 101.01 ? 463 ASP A CB    1 
ATOM   3898 C  CG    . ASP A 1 473 ? 171.236 181.561 149.770 1.00 98.11  ? 463 ASP A CG    1 
ATOM   3899 O  OD1   . ASP A 1 473 ? 171.693 181.281 150.897 1.00 94.09  ? 463 ASP A OD1   1 
ATOM   3900 O  OD2   . ASP A 1 473 ? 171.899 181.436 148.719 1.00 94.61  ? 463 ASP A OD2   1 
ATOM   3901 N  N     . SER A 1 474 ? 166.711 181.508 150.084 1.00 96.84  ? 464 SER A N     1 
ATOM   3902 C  CA    . SER A 1 474 ? 165.312 181.863 149.904 1.00 96.67  ? 464 SER A CA    1 
ATOM   3903 C  C     . SER A 1 474 ? 164.489 180.587 149.862 1.00 95.43  ? 464 SER A C     1 
ATOM   3904 O  O     . SER A 1 474 ? 164.779 179.686 149.072 1.00 98.14  ? 464 SER A O     1 
ATOM   3905 C  CB    . SER A 1 474 ? 165.108 182.673 148.620 1.00 98.71  ? 464 SER A CB    1 
ATOM   3906 O  OG    . SER A 1 474 ? 165.799 183.908 148.682 1.00 99.65  ? 464 SER A OG    1 
ATOM   3907 N  N     . THR A 1 475 ? 163.466 180.513 150.709 1.00 90.69  ? 465 THR A N     1 
ATOM   3908 C  CA    . THR A 1 475 ? 162.630 179.327 150.824 1.00 94.47  ? 465 THR A CA    1 
ATOM   3909 C  C     . THR A 1 475 ? 161.363 179.407 149.983 1.00 93.08  ? 465 THR A C     1 
ATOM   3910 O  O     . THR A 1 475 ? 160.504 178.526 150.096 1.00 88.47  ? 465 THR A O     1 
ATOM   3911 C  CB    . THR A 1 475 ? 162.254 179.089 152.286 1.00 92.14  ? 465 THR A CB    1 
ATOM   3912 O  OG1   . THR A 1 475 ? 161.412 177.935 152.381 1.00 91.78  ? 465 THR A OG1   1 
ATOM   3913 C  CG2   . THR A 1 475 ? 161.513 180.295 152.841 1.00 83.34  ? 465 THR A CG2   1 
ATOM   3914 N  N     . GLU A 1 476 ? 161.226 180.438 149.147 1.00 94.90  ? 466 GLU A N     1 
ATOM   3915 C  CA    . GLU A 1 476 ? 159.985 180.631 148.404 1.00 91.03  ? 466 GLU A CA    1 
ATOM   3916 C  C     . GLU A 1 476 ? 159.776 179.555 147.345 1.00 92.41  ? 466 GLU A C     1 
ATOM   3917 O  O     . GLU A 1 476 ? 158.631 179.259 146.986 1.00 94.98  ? 466 GLU A O     1 
ATOM   3918 C  CB    . GLU A 1 476 ? 159.971 182.021 147.767 1.00 94.08  ? 466 GLU A CB    1 
ATOM   3919 C  CG    . GLU A 1 476 ? 158.683 182.360 147.036 1.00 95.35  ? 466 GLU A CG    1 
ATOM   3920 C  CD    . GLU A 1 476 ? 158.534 183.841 146.762 1.00 96.99  ? 466 GLU A CD    1 
ATOM   3921 O  OE1   . GLU A 1 476 ? 159.190 184.645 147.455 1.00 101.77 ? 466 GLU A OE1   1 
ATOM   3922 O  OE2   . GLU A 1 476 ? 157.761 184.202 145.850 1.00 90.95  ? 466 GLU A OE2   1 
ATOM   3923 N  N     . SER A 1 477 ? 160.851 178.960 146.835 1.00 96.38  ? 467 SER A N     1 
ATOM   3924 C  CA    . SER A 1 477 ? 160.723 177.957 145.786 1.00 96.69  ? 467 SER A CA    1 
ATOM   3925 C  C     . SER A 1 477 ? 161.933 177.035 145.830 1.00 99.76  ? 467 SER A C     1 
ATOM   3926 O  O     . SER A 1 477 ? 162.957 177.345 146.444 1.00 100.47 ? 467 SER A O     1 
ATOM   3927 C  CB    . SER A 1 477 ? 160.575 178.607 144.407 1.00 95.27  ? 467 SER A CB    1 
ATOM   3928 O  OG    . SER A 1 477 ? 160.425 177.625 143.398 1.00 97.24  ? 467 SER A OG    1 
ATOM   3929 N  N     . LYS A 1 478 ? 161.802 175.894 145.148 1.00 100.92 ? 468 LYS A N     1 
ATOM   3930 C  CA    . LYS A 1 478 ? 162.813 174.843 145.233 1.00 97.78  ? 468 LYS A CA    1 
ATOM   3931 C  C     . LYS A 1 478 ? 164.163 175.311 144.703 1.00 97.11  ? 468 LYS A C     1 
ATOM   3932 O  O     . LYS A 1 478 ? 165.208 175.001 145.286 1.00 92.53  ? 468 LYS A O     1 
ATOM   3933 C  CB    . LYS A 1 478 ? 162.338 173.604 144.474 1.00 84.10  ? 468 LYS A CB    1 
ATOM   3934 C  CG    . LYS A 1 478 ? 163.388 172.517 144.341 1.00 82.86  ? 468 LYS A CG    1 
ATOM   3935 C  CD    . LYS A 1 478 ? 162.759 171.158 144.097 1.00 79.92  ? 468 LYS A CD    1 
ATOM   3936 C  CE    . LYS A 1 478 ? 161.563 171.254 143.167 1.00 81.22  ? 468 LYS A CE    1 
ATOM   3937 N  NZ    . LYS A 1 478 ? 160.865 169.948 143.026 1.00 86.60  ? 468 LYS A NZ    1 
ATOM   3938 N  N     . GLU A 1 479 ? 164.164 176.064 143.603 1.00 98.67  ? 469 GLU A N     1 
ATOM   3939 C  CA    . GLU A 1 479 ? 165.412 176.479 142.975 1.00 100.89 ? 469 GLU A CA    1 
ATOM   3940 C  C     . GLU A 1 479 ? 166.218 177.452 143.827 1.00 100.92 ? 469 GLU A C     1 
ATOM   3941 O  O     . GLU A 1 479 ? 167.383 177.706 143.506 1.00 101.46 ? 469 GLU A O     1 
ATOM   3942 C  CB    . GLU A 1 479 ? 165.128 177.111 141.613 1.00 103.01 ? 469 GLU A CB    1 
ATOM   3943 C  CG    . GLU A 1 479 ? 164.424 178.455 141.692 1.00 105.26 ? 469 GLU A CG    1 
ATOM   3944 C  CD    . GLU A 1 479 ? 162.920 178.328 141.795 1.00 106.95 ? 469 GLU A CD    1 
ATOM   3945 O  OE1   . GLU A 1 479 ? 162.433 177.219 142.095 1.00 105.49 ? 469 GLU A OE1   1 
ATOM   3946 O  OE2   . GLU A 1 479 ? 162.222 179.340 141.583 1.00 107.87 ? 469 GLU A OE2   1 
ATOM   3947 N  N     . SER A 1 480 ? 165.636 178.001 144.892 1.00 99.97  ? 470 SER A N     1 
ATOM   3948 C  CA    . SER A 1 480 ? 166.329 178.959 145.741 1.00 102.11 ? 470 SER A CA    1 
ATOM   3949 C  C     . SER A 1 480 ? 166.807 178.367 147.061 1.00 101.88 ? 470 SER A C     1 
ATOM   3950 O  O     . SER A 1 480 ? 167.510 179.055 147.808 1.00 99.61  ? 470 SER A O     1 
ATOM   3951 C  CB    . SER A 1 480 ? 165.423 180.162 146.025 1.00 99.38  ? 470 SER A CB    1 
ATOM   3952 O  OG    . SER A 1 480 ? 165.149 180.885 144.840 1.00 100.93 ? 470 SER A OG    1 
ATOM   3953 N  N     . MET A 1 481 ? 166.452 177.120 147.366 1.00 99.35  ? 471 MET A N     1 
ATOM   3954 C  CA    . MET A 1 481 ? 166.824 176.499 148.627 1.00 95.37  ? 471 MET A CA    1 
ATOM   3955 C  C     . MET A 1 481 ? 168.163 175.774 148.485 1.00 93.93  ? 471 MET A C     1 
ATOM   3956 O  O     . MET A 1 481 ? 168.839 175.861 147.457 1.00 93.30  ? 471 MET A O     1 
ATOM   3957 C  CB    . MET A 1 481 ? 165.722 175.556 149.094 1.00 93.38  ? 471 MET A CB    1 
ATOM   3958 C  CG    . MET A 1 481 ? 164.398 176.239 149.369 1.00 97.17  ? 471 MET A CG    1 
ATOM   3959 S  SD    . MET A 1 481 ? 163.183 175.097 150.046 1.00 100.93 ? 471 MET A SD    1 
ATOM   3960 C  CE    . MET A 1 481 ? 163.703 173.579 149.255 1.00 91.17  ? 471 MET A CE    1 
ATOM   3961 N  N     . ASP A 1 482 ? 168.561 175.053 149.529 1.00 92.47  ? 472 ASP A N     1 
ATOM   3962 C  CA    . ASP A 1 482 ? 169.830 174.341 149.503 1.00 90.99  ? 472 ASP A CA    1 
ATOM   3963 C  C     . ASP A 1 482 ? 169.720 173.095 148.634 1.00 87.86  ? 472 ASP A C     1 
ATOM   3964 O  O     . ASP A 1 482 ? 168.687 172.420 148.611 1.00 87.41  ? 472 ASP A O     1 
ATOM   3965 C  CB    . ASP A 1 482 ? 170.259 173.960 150.918 1.00 91.25  ? 472 ASP A CB    1 
ATOM   3966 C  CG    . ASP A 1 482 ? 171.737 173.636 151.010 1.00 90.67  ? 472 ASP A CG    1 
ATOM   3967 O  OD1   . ASP A 1 482 ? 172.532 174.265 150.279 1.00 84.98  ? 472 ASP A OD1   1 
ATOM   3968 O  OD2   . ASP A 1 482 ? 172.105 172.758 151.818 1.00 94.46  ? 472 ASP A OD2   1 
ATOM   3969 N  N     . LYS A 1 483 ? 170.799 172.793 147.914 1.00 85.86  ? 473 LYS A N     1 
ATOM   3970 C  CA    . LYS A 1 483 ? 170.773 171.695 146.958 1.00 83.95  ? 473 LYS A CA    1 
ATOM   3971 C  C     . LYS A 1 483 ? 170.755 170.332 147.638 1.00 86.03  ? 473 LYS A C     1 
ATOM   3972 O  O     . LYS A 1 483 ? 170.244 169.364 147.062 1.00 84.90  ? 473 LYS A O     1 
ATOM   3973 C  CB    . LYS A 1 483 ? 171.973 171.803 146.017 1.00 81.81  ? 473 LYS A CB    1 
ATOM   3974 C  CG    . LYS A 1 483 ? 171.996 173.088 145.209 1.00 79.36  ? 473 LYS A CG    1 
ATOM   3975 C  CD    . LYS A 1 483 ? 170.638 173.354 144.585 1.00 80.52  ? 473 LYS A CD    1 
ATOM   3976 C  CE    . LYS A 1 483 ? 170.622 174.651 143.801 1.00 80.85  ? 473 LYS A CE    1 
ATOM   3977 N  NZ    . LYS A 1 483 ? 169.309 174.863 143.131 1.00 84.31  ? 473 LYS A NZ    1 
ATOM   3978 N  N     . ARG A 1 484 ? 171.293 170.234 148.855 1.00 84.71  ? 474 ARG A N     1 
ATOM   3979 C  CA    . ARG A 1 484 ? 171.346 168.945 149.533 1.00 83.66  ? 474 ARG A CA    1 
ATOM   3980 C  C     . ARG A 1 484 ? 169.968 168.449 149.951 1.00 83.05  ? 474 ARG A C     1 
ATOM   3981 O  O     . ARG A 1 484 ? 169.827 167.266 150.280 1.00 84.25  ? 474 ARG A O     1 
ATOM   3982 C  CB    . ARG A 1 484 ? 172.268 169.029 150.747 1.00 81.68  ? 474 ARG A CB    1 
ATOM   3983 C  CG    . ARG A 1 484 ? 173.506 169.875 150.519 1.00 77.44  ? 474 ARG A CG    1 
ATOM   3984 C  CD    . ARG A 1 484 ? 174.506 169.675 151.638 1.00 79.58  ? 474 ARG A CD    1 
ATOM   3985 N  NE    . ARG A 1 484 ? 175.536 170.705 151.650 1.00 79.18  ? 474 ARG A NE    1 
ATOM   3986 C  CZ    . ARG A 1 484 ? 175.462 171.824 152.355 1.00 81.27  ? 474 ARG A CZ    1 
ATOM   3987 N  NH1   . ARG A 1 484 ? 174.410 172.099 153.108 1.00 82.13  ? 474 ARG A NH1   1 
ATOM   3988 N  NH2   . ARG A 1 484 ? 176.468 172.691 152.301 1.00 77.45  ? 474 ARG A NH2   1 
ATOM   3989 N  N     . ARG A 1 485 ? 168.953 169.319 149.950 1.00 80.29  ? 475 ARG A N     1 
ATOM   3990 C  CA    . ARG A 1 485 ? 167.584 168.855 150.148 1.00 77.51  ? 475 ARG A CA    1 
ATOM   3991 C  C     . ARG A 1 485 ? 167.238 167.717 149.200 1.00 76.49  ? 475 ARG A C     1 
ATOM   3992 O  O     . ARG A 1 485 ? 166.562 166.761 149.597 1.00 72.47  ? 475 ARG A O     1 
ATOM   3993 C  CB    . ARG A 1 485 ? 166.594 170.007 149.956 1.00 76.75  ? 475 ARG A CB    1 
ATOM   3994 C  CG    . ARG A 1 485 ? 166.702 171.158 150.944 1.00 77.63  ? 475 ARG A CG    1 
ATOM   3995 C  CD    . ARG A 1 485 ? 166.230 170.712 152.315 1.00 76.07  ? 475 ARG A CD    1 
ATOM   3996 N  NE    . ARG A 1 485 ? 166.295 171.763 153.323 1.00 72.34  ? 475 ARG A NE    1 
ATOM   3997 C  CZ    . ARG A 1 485 ? 165.310 172.608 153.589 1.00 68.07  ? 475 ARG A CZ    1 
ATOM   3998 N  NH1   . ARG A 1 485 ? 164.180 172.590 152.906 1.00 70.51  ? 475 ARG A NH1   1 
ATOM   3999 N  NH2   . ARG A 1 485 ? 165.462 173.495 154.566 1.00 65.51  ? 475 ARG A NH2   1 
ATOM   4000 N  N     . THR A 1 486 ? 167.697 167.792 147.953 1.00 75.89  ? 476 THR A N     1 
ATOM   4001 C  CA    . THR A 1 486 ? 167.371 166.783 146.956 1.00 75.97  ? 476 THR A CA    1 
ATOM   4002 C  C     . THR A 1 486 ? 168.535 165.857 146.631 1.00 80.75  ? 476 THR A C     1 
ATOM   4003 O  O     . THR A 1 486 ? 168.303 164.696 146.279 1.00 82.95  ? 476 THR A O     1 
ATOM   4004 C  CB    . THR A 1 486 ? 166.883 167.453 145.668 1.00 74.58  ? 476 THR A CB    1 
ATOM   4005 O  OG1   . THR A 1 486 ? 166.007 168.536 146.000 1.00 70.84  ? 476 THR A OG1   1 
ATOM   4006 C  CG2   . THR A 1 486 ? 166.123 166.459 144.808 1.00 73.05  ? 476 THR A CG2   1 
ATOM   4007 N  N     . GLU A 1 487 ? 169.777 166.331 146.740 1.00 84.30  ? 477 GLU A N     1 
ATOM   4008 C  CA    . GLU A 1 487 ? 170.924 165.472 146.454 1.00 89.98  ? 477 GLU A CA    1 
ATOM   4009 C  C     . GLU A 1 487 ? 171.053 164.348 147.475 1.00 86.38  ? 477 GLU A C     1 
ATOM   4010 O  O     . GLU A 1 487 ? 171.152 163.172 147.111 1.00 82.93  ? 477 GLU A O     1 
ATOM   4011 C  CB    . GLU A 1 487 ? 172.211 166.300 146.411 1.00 90.87  ? 477 GLU A CB    1 
ATOM   4012 C  CG    . GLU A 1 487 ? 172.271 167.320 145.292 1.00 95.33  ? 477 GLU A CG    1 
ATOM   4013 C  CD    . GLU A 1 487 ? 172.572 166.695 143.946 1.00 101.52 ? 477 GLU A CD    1 
ATOM   4014 O  OE1   . GLU A 1 487 ? 172.738 165.459 143.884 1.00 101.97 ? 477 GLU A OE1   1 
ATOM   4015 O  OE2   . GLU A 1 487 ? 172.643 167.439 142.946 1.00 104.56 ? 477 GLU A OE2   1 
ATOM   4016 N  N     . PHE A 1 488 ? 171.033 164.688 148.765 1.00 81.43  ? 478 PHE A N     1 
ATOM   4017 C  CA    . PHE A 1 488 ? 171.254 163.728 149.843 1.00 76.39  ? 478 PHE A CA    1 
ATOM   4018 C  C     . PHE A 1 488 ? 170.085 163.784 150.817 1.00 71.93  ? 478 PHE A C     1 
ATOM   4019 O  O     . PHE A 1 488 ? 170.174 164.420 151.878 1.00 68.96  ? 478 PHE A O     1 
ATOM   4020 C  CB    . PHE A 1 488 ? 172.572 163.993 150.567 1.00 77.92  ? 478 PHE A CB    1 
ATOM   4021 C  CG    . PHE A 1 488 ? 173.743 164.176 149.651 1.00 84.89  ? 478 PHE A CG    1 
ATOM   4022 C  CD1   . PHE A 1 488 ? 174.350 163.084 149.060 1.00 86.40  ? 478 PHE A CD1   1 
ATOM   4023 C  CD2   . PHE A 1 488 ? 174.248 165.438 149.394 1.00 88.08  ? 478 PHE A CD2   1 
ATOM   4024 C  CE1   . PHE A 1 488 ? 175.432 163.249 148.222 1.00 88.30  ? 478 PHE A CE1   1 
ATOM   4025 C  CE2   . PHE A 1 488 ? 175.328 165.608 148.557 1.00 90.23  ? 478 PHE A CE2   1 
ATOM   4026 C  CZ    . PHE A 1 488 ? 175.920 164.512 147.970 1.00 92.23  ? 478 PHE A CZ    1 
ATOM   4027 N  N     . PRO A 1 489 ? 168.979 163.128 150.498 1.00 70.61  ? 479 PRO A N     1 
ATOM   4028 C  CA    . PRO A 1 489 ? 167.864 163.032 151.439 1.00 63.04  ? 479 PRO A CA    1 
ATOM   4029 C  C     . PRO A 1 489 ? 168.198 162.033 152.542 1.00 62.82  ? 479 PRO A C     1 
ATOM   4030 O  O     . PRO A 1 489 ? 169.191 161.313 152.483 1.00 65.58  ? 479 PRO A O     1 
ATOM   4031 C  CB    . PRO A 1 489 ? 166.704 162.541 150.565 1.00 57.27  ? 479 PRO A CB    1 
ATOM   4032 C  CG    . PRO A 1 489 ? 167.197 162.638 149.140 1.00 59.24  ? 479 PRO A CG    1 
ATOM   4033 C  CD    . PRO A 1 489 ? 168.667 162.466 149.226 1.00 68.02  ? 479 PRO A CD    1 
ATOM   4034 N  N     . PHE A 1 490 ? 167.353 162.014 153.571 1.00 59.11  ? 480 PHE A N     1 
ATOM   4035 C  CA    . PHE A 1 490 ? 167.464 160.977 154.586 1.00 51.93  ? 480 PHE A CA    1 
ATOM   4036 C  C     . PHE A 1 490 ? 166.983 159.630 154.074 1.00 48.45  ? 480 PHE A C     1 
ATOM   4037 O  O     . PHE A 1 490 ? 167.374 158.595 154.619 1.00 48.06  ? 480 PHE A O     1 
ATOM   4038 C  CB    . PHE A 1 490 ? 166.678 161.369 155.837 1.00 46.18  ? 480 PHE A CB    1 
ATOM   4039 C  CG    . PHE A 1 490 ? 166.723 160.339 156.925 1.00 43.73  ? 480 PHE A CG    1 
ATOM   4040 C  CD1   . PHE A 1 490 ? 167.886 160.116 157.636 1.00 47.03  ? 480 PHE A CD1   1 
ATOM   4041 C  CD2   . PHE A 1 490 ? 165.605 159.592 157.235 1.00 42.08  ? 480 PHE A CD2   1 
ATOM   4042 C  CE1   . PHE A 1 490 ? 167.931 159.172 158.631 1.00 46.68  ? 480 PHE A CE1   1 
ATOM   4043 C  CE2   . PHE A 1 490 ? 165.645 158.648 158.233 1.00 38.99  ? 480 PHE A CE2   1 
ATOM   4044 C  CZ    . PHE A 1 490 ? 166.808 158.437 158.931 1.00 44.89  ? 480 PHE A CZ    1 
ATOM   4045 N  N     . ARG A 1 491 ? 166.154 159.619 153.033 1.00 47.17  ? 481 ARG A N     1 
ATOM   4046 C  CA    . ARG A 1 491 ? 165.693 158.358 152.470 1.00 47.35  ? 481 ARG A CA    1 
ATOM   4047 C  C     . ARG A 1 491 ? 166.838 157.566 151.857 1.00 52.11  ? 481 ARG A C     1 
ATOM   4048 O  O     . ARG A 1 491 ? 166.799 156.331 151.843 1.00 54.44  ? 481 ARG A O     1 
ATOM   4049 C  CB    . ARG A 1 491 ? 164.607 158.631 151.431 1.00 50.67  ? 481 ARG A CB    1 
ATOM   4050 C  CG    . ARG A 1 491 ? 164.084 157.399 150.728 1.00 49.19  ? 481 ARG A CG    1 
ATOM   4051 C  CD    . ARG A 1 491 ? 163.421 156.457 151.698 1.00 44.32  ? 481 ARG A CD    1 
ATOM   4052 N  NE    . ARG A 1 491 ? 162.961 155.248 151.031 1.00 50.45  ? 481 ARG A NE    1 
ATOM   4053 C  CZ    . ARG A 1 491 ? 163.654 154.121 150.967 1.00 56.37  ? 481 ARG A CZ    1 
ATOM   4054 N  NH1   . ARG A 1 491 ? 164.844 154.011 151.531 1.00 59.21  ? 481 ARG A NH1   1 
ATOM   4055 N  NH2   . ARG A 1 491 ? 163.139 153.078 150.324 1.00 53.03  ? 481 ARG A NH2   1 
ATOM   4056 N  N     . ASN A 1 492 ? 167.864 158.250 151.356 1.00 55.30  ? 482 ASN A N     1 
ATOM   4057 C  CA    . ASN A 1 492 ? 168.988 157.593 150.706 1.00 55.04  ? 482 ASN A CA    1 
ATOM   4058 C  C     . ASN A 1 492 ? 170.123 157.255 151.661 1.00 55.66  ? 482 ASN A C     1 
ATOM   4059 O  O     . ASN A 1 492 ? 171.074 156.581 151.253 1.00 61.60  ? 482 ASN A O     1 
ATOM   4060 C  CB    . ASN A 1 492 ? 169.512 158.469 149.570 1.00 56.22  ? 482 ASN A CB    1 
ATOM   4061 C  CG    . ASN A 1 492 ? 168.492 158.657 148.473 1.00 57.31  ? 482 ASN A CG    1 
ATOM   4062 O  OD1   . ASN A 1 492 ? 167.419 158.059 148.502 1.00 49.26  ? 482 ASN A OD1   1 
ATOM   4063 N  ND2   . ASN A 1 492 ? 168.818 159.493 147.499 1.00 61.87  ? 482 ASN A ND2   1 
ATOM   4064 N  N     . THR A 1 493 ? 170.050 157.701 152.909 1.00 52.72  ? 483 THR A N     1 
ATOM   4065 C  CA    . THR A 1 493 ? 171.039 157.326 153.904 1.00 50.65  ? 483 THR A CA    1 
ATOM   4066 C  C     . THR A 1 493 ? 170.926 155.830 154.216 1.00 58.53  ? 483 THR A C     1 
ATOM   4067 O  O     . THR A 1 493 ? 169.830 155.266 154.197 1.00 59.63  ? 483 THR A O     1 
ATOM   4068 C  CB    . THR A 1 493 ? 170.832 158.152 155.173 1.00 48.84  ? 483 THR A CB    1 
ATOM   4069 O  OG1   . THR A 1 493 ? 170.964 159.542 154.858 1.00 57.12  ? 483 THR A OG1   1 
ATOM   4070 C  CG2   . THR A 1 493 ? 171.844 157.802 156.242 1.00 46.27  ? 483 THR A CG2   1 
ATOM   4071 N  N     . PRO A 1 494 ? 172.052 155.157 154.473 1.00 62.84  ? 484 PRO A N     1 
ATOM   4072 C  CA    . PRO A 1 494 ? 171.977 153.744 154.883 1.00 54.73  ? 484 PRO A CA    1 
ATOM   4073 C  C     . PRO A 1 494 ? 171.136 153.508 156.124 1.00 53.23  ? 484 PRO A C     1 
ATOM   4074 O  O     . PRO A 1 494 ? 170.518 152.443 156.247 1.00 50.79  ? 484 PRO A O     1 
ATOM   4075 C  CB    . PRO A 1 494 ? 173.445 153.381 155.127 1.00 48.72  ? 484 PRO A CB    1 
ATOM   4076 C  CG    . PRO A 1 494 ? 174.198 154.270 154.214 1.00 56.93  ? 484 PRO A CG    1 
ATOM   4077 C  CD    . PRO A 1 494 ? 173.426 155.558 154.121 1.00 58.53  ? 484 PRO A CD    1 
ATOM   4078 N  N     . VAL A 1 495 ? 171.093 154.472 157.046 1.00 52.09  ? 485 VAL A N     1 
ATOM   4079 C  CA    . VAL A 1 495 ? 170.370 154.286 158.302 1.00 45.35  ? 485 VAL A CA    1 
ATOM   4080 C  C     . VAL A 1 495 ? 168.879 154.090 158.050 1.00 50.33  ? 485 VAL A C     1 
ATOM   4081 O  O     . VAL A 1 495 ? 168.237 153.243 158.680 1.00 53.04  ? 485 VAL A O     1 
ATOM   4082 C  CB    . VAL A 1 495 ? 170.636 155.475 159.243 1.00 48.84  ? 485 VAL A CB    1 
ATOM   4083 C  CG1   . VAL A 1 495 ? 169.751 155.399 160.467 1.00 49.32  ? 485 VAL A CG1   1 
ATOM   4084 C  CG2   . VAL A 1 495 ? 172.098 155.508 159.643 1.00 48.31  ? 485 VAL A CG2   1 
ATOM   4085 N  N     . ALA A 1 496 ? 168.303 154.871 157.132 1.00 46.38  ? 486 ALA A N     1 
ATOM   4086 C  CA    . ALA A 1 496 ? 166.864 154.804 156.892 1.00 43.54  ? 486 ALA A CA    1 
ATOM   4087 C  C     . ALA A 1 496 ? 166.454 153.466 156.290 1.00 45.37  ? 486 ALA A C     1 
ATOM   4088 O  O     . ALA A 1 496 ? 165.473 152.855 156.728 1.00 47.03  ? 486 ALA A O     1 
ATOM   4089 C  CB    . ALA A 1 496 ? 166.429 155.950 155.981 1.00 38.97  ? 486 ALA A CB    1 
ATOM   4090 N  N     . ASN A 1 497 ? 167.190 152.997 155.279 1.00 45.83  ? 487 ASN A N     1 
ATOM   4091 C  CA    . ASN A 1 497 ? 166.820 151.759 154.598 1.00 46.51  ? 487 ASN A CA    1 
ATOM   4092 C  C     . ASN A 1 497 ? 166.702 150.599 155.578 1.00 48.22  ? 487 ASN A C     1 
ATOM   4093 O  O     . ASN A 1 497 ? 165.812 149.753 155.446 1.00 49.70  ? 487 ASN A O     1 
ATOM   4094 C  CB    . ASN A 1 497 ? 167.839 151.436 153.507 1.00 49.33  ? 487 ASN A CB    1 
ATOM   4095 C  CG    . ASN A 1 497 ? 167.777 152.405 152.349 1.00 53.26  ? 487 ASN A CG    1 
ATOM   4096 O  OD1   . ASN A 1 497 ? 167.005 153.360 152.366 1.00 55.46  ? 487 ASN A OD1   1 
ATOM   4097 N  ND2   . ASN A 1 497 ? 168.591 152.162 151.332 1.00 51.17  ? 487 ASN A ND2   1 
ATOM   4098 N  N     . GLU A 1 498 ? 167.592 150.548 156.567 1.00 48.91  ? 488 GLU A N     1 
ATOM   4099 C  CA    . GLU A 1 498 ? 167.502 149.536 157.612 1.00 40.64  ? 488 GLU A CA    1 
ATOM   4100 C  C     . GLU A 1 498 ? 166.217 149.693 158.413 1.00 42.44  ? 488 GLU A C     1 
ATOM   4101 O  O     . GLU A 1 498 ? 165.465 148.728 158.610 1.00 47.01  ? 488 GLU A O     1 
ATOM   4102 C  CB    . GLU A 1 498 ? 168.728 149.647 158.516 1.00 41.46  ? 488 GLU A CB    1 
ATOM   4103 C  CG    . GLU A 1 498 ? 168.923 148.524 159.501 1.00 52.52  ? 488 GLU A CG    1 
ATOM   4104 C  CD    . GLU A 1 498 ? 170.077 148.797 160.444 1.00 58.81  ? 488 GLU A CD    1 
ATOM   4105 O  OE1   . GLU A 1 498 ? 170.497 149.969 160.542 1.00 53.56  ? 488 GLU A OE1   1 
ATOM   4106 O  OE2   . GLU A 1 498 ? 170.571 147.844 161.082 1.00 61.53  ? 488 GLU A OE2   1 
ATOM   4107 N  N     . LEU A 1 499 ? 165.940 150.916 158.870 1.00 41.73  ? 489 LEU A N     1 
ATOM   4108 C  CA    . LEU A 1 499 ? 164.737 151.162 159.657 1.00 38.69  ? 489 LEU A CA    1 
ATOM   4109 C  C     . LEU A 1 499 ? 163.478 150.946 158.832 1.00 37.25  ? 489 LEU A C     1 
ATOM   4110 O  O     . LEU A 1 499 ? 162.490 150.403 159.335 1.00 41.15  ? 489 LEU A O     1 
ATOM   4111 C  CB    . LEU A 1 499 ? 164.762 152.575 160.232 1.00 40.41  ? 489 LEU A CB    1 
ATOM   4112 C  CG    . LEU A 1 499 ? 165.575 152.763 161.510 1.00 43.13  ? 489 LEU A CG    1 
ATOM   4113 C  CD1   . LEU A 1 499 ? 165.713 154.236 161.832 1.00 44.39  ? 489 LEU A CD1   1 
ATOM   4114 C  CD2   . LEU A 1 499 ? 164.940 152.014 162.661 1.00 35.98  ? 489 LEU A CD2   1 
ATOM   4115 N  N     . LEU A 1 500 ? 163.490 151.366 157.567 1.00 39.88  ? 490 LEU A N     1 
ATOM   4116 C  CA    . LEU A 1 500 ? 162.320 151.163 156.718 1.00 38.51  ? 490 LEU A CA    1 
ATOM   4117 C  C     . LEU A 1 500 ? 162.089 149.687 156.432 1.00 34.90  ? 490 LEU A C     1 
ATOM   4118 O  O     . LEU A 1 500 ? 160.942 149.238 156.362 1.00 38.62  ? 490 LEU A O     1 
ATOM   4119 C  CB    . LEU A 1 500 ? 162.466 151.948 155.418 1.00 35.74  ? 490 LEU A CB    1 
ATOM   4120 C  CG    . LEU A 1 500 ? 162.440 153.465 155.584 1.00 39.84  ? 490 LEU A CG    1 
ATOM   4121 C  CD1   . LEU A 1 500 ? 162.542 154.130 154.241 1.00 44.08  ? 490 LEU A CD1   1 
ATOM   4122 C  CD2   . LEU A 1 500 ? 161.184 153.901 156.297 1.00 39.93  ? 490 LEU A CD2   1 
ATOM   4123 N  N     . SER A 1 501 ? 163.162 148.915 156.261 1.00 39.63  ? 491 SER A N     1 
ATOM   4124 C  CA    . SER A 1 501 ? 163.008 147.478 156.071 1.00 40.61  ? 491 SER A CA    1 
ATOM   4125 C  C     . SER A 1 501 ? 162.417 146.822 157.310 1.00 39.20  ? 491 SER A C     1 
ATOM   4126 O  O     . SER A 1 501 ? 161.523 145.971 157.208 1.00 35.77  ? 491 SER A O     1 
ATOM   4127 C  CB    . SER A 1 501 ? 164.356 146.849 155.723 1.00 35.87  ? 491 SER A CB    1 
ATOM   4128 O  OG    . SER A 1 501 ? 165.195 146.791 156.862 1.00 40.06  ? 491 SER A OG    1 
ATOM   4129 N  N     . LYS A 1 502 ? 162.904 147.206 158.493 1.00 38.30  ? 492 LYS A N     1 
ATOM   4130 C  CA    . LYS A 1 502 ? 162.350 146.655 159.727 1.00 33.82  ? 492 LYS A CA    1 
ATOM   4131 C  C     . LYS A 1 502 ? 160.886 147.042 159.893 1.00 37.03  ? 492 LYS A C     1 
ATOM   4132 O  O     . LYS A 1 502 ? 160.060 146.223 160.318 1.00 40.00  ? 492 LYS A O     1 
ATOM   4133 C  CB    . LYS A 1 502 ? 163.174 147.123 160.921 1.00 34.98  ? 492 LYS A CB    1 
ATOM   4134 C  CG    . LYS A 1 502 ? 164.626 146.706 160.859 1.00 36.27  ? 492 LYS A CG    1 
ATOM   4135 C  CD    . LYS A 1 502 ? 165.427 147.334 161.980 1.00 40.54  ? 492 LYS A CD    1 
ATOM   4136 C  CE    . LYS A 1 502 ? 166.864 146.865 161.953 1.00 39.86  ? 492 LYS A CE    1 
ATOM   4137 N  NZ    . LYS A 1 502 ? 167.629 147.394 163.104 1.00 45.12  ? 492 LYS A NZ    1 
ATOM   4138 N  N     . LEU A 1 503 ? 160.547 148.287 159.557 1.00 37.52  ? 493 LEU A N     1 
ATOM   4139 C  CA    . LEU A 1 503 ? 159.160 148.731 159.620 1.00 33.08  ? 493 LEU A CA    1 
ATOM   4140 C  C     . LEU A 1 503 ? 158.285 147.937 158.664 1.00 33.23  ? 493 LEU A C     1 
ATOM   4141 O  O     . LEU A 1 503 ? 157.153 147.584 159.000 1.00 39.22  ? 493 LEU A O     1 
ATOM   4142 C  CB    . LEU A 1 503 ? 159.076 150.221 159.303 1.00 31.64  ? 493 LEU A CB    1 
ATOM   4143 C  CG    . LEU A 1 503 ? 159.386 151.203 160.430 1.00 29.58  ? 493 LEU A CG    1 
ATOM   4144 C  CD1   . LEU A 1 503 ? 159.808 152.537 159.859 1.00 30.34  ? 493 LEU A CD1   1 
ATOM   4145 C  CD2   . LEU A 1 503 ? 158.182 151.367 161.321 1.00 30.46  ? 493 LEU A CD2   1 
ATOM   4146 N  N     . ASN A 1 504 ? 158.790 147.658 157.461 1.00 33.04  ? 494 ASN A N     1 
ATOM   4147 C  CA    . ASN A 1 504 ? 158.037 146.856 156.503 1.00 32.65  ? 494 ASN A CA    1 
ATOM   4148 C  C     . ASN A 1 504 ? 157.805 145.446 157.023 1.00 32.41  ? 494 ASN A C     1 
ATOM   4149 O  O     . ASN A 1 504 ? 156.712 144.893 156.870 1.00 33.25  ? 494 ASN A O     1 
ATOM   4150 C  CB    . ASN A 1 504 ? 158.772 146.815 155.167 1.00 36.40  ? 494 ASN A CB    1 
ATOM   4151 C  CG    . ASN A 1 504 ? 158.323 147.902 154.226 1.00 41.19  ? 494 ASN A CG    1 
ATOM   4152 O  OD1   . ASN A 1 504 ? 157.416 148.670 154.537 1.00 40.42  ? 494 ASN A OD1   1 
ATOM   4153 N  ND2   . ASN A 1 504 ? 158.956 147.977 153.066 1.00 47.06  ? 494 ASN A ND2   1 
ATOM   4154 N  N     . ASN A 1 505 ? 158.824 144.847 157.640 1.00 33.23  ? 495 ASN A N     1 
ATOM   4155 C  CA    . ASN A 1 505 ? 158.657 143.511 158.206 1.00 30.32  ? 495 ASN A CA    1 
ATOM   4156 C  C     . ASN A 1 505 ? 157.604 143.507 159.307 1.00 31.35  ? 495 ASN A C     1 
ATOM   4157 O  O     . ASN A 1 505 ? 156.738 142.620 159.354 1.00 34.23  ? 495 ASN A O     1 
ATOM   4158 C  CB    . ASN A 1 505 ? 159.991 143.002 158.747 1.00 33.25  ? 495 ASN A CB    1 
ATOM   4159 C  CG    . ASN A 1 505 ? 161.104 143.082 157.728 1.00 36.10  ? 495 ASN A CG    1 
ATOM   4160 O  OD1   . ASN A 1 505 ? 160.857 143.147 156.528 1.00 40.28  ? 495 ASN A OD1   1 
ATOM   4161 N  ND2   . ASN A 1 505 ? 162.341 143.088 158.204 1.00 31.78  ? 495 ASN A ND2   1 
ATOM   4162 N  N     . VAL A 1 506 ? 157.656 144.498 160.198 1.00 28.02  ? 496 VAL A N     1 
ATOM   4163 C  CA    . VAL A 1 506 ? 156.686 144.558 161.287 1.00 27.76  ? 496 VAL A CA    1 
ATOM   4164 C  C     . VAL A 1 506 ? 155.281 144.799 160.748 1.00 27.20  ? 496 VAL A C     1 
ATOM   4165 O  O     . VAL A 1 506 ? 154.312 144.204 161.228 1.00 31.83  ? 496 VAL A O     1 
ATOM   4166 C  CB    . VAL A 1 506 ? 157.094 145.628 162.315 1.00 29.87  ? 496 VAL A CB    1 
ATOM   4167 C  CG1   . VAL A 1 506 ? 156.058 145.720 163.411 1.00 25.60  ? 496 VAL A CG1   1 
ATOM   4168 C  CG2   . VAL A 1 506 ? 158.435 145.294 162.906 1.00 26.72  ? 496 VAL A CG2   1 
ATOM   4169 N  N     . GLN A 1 507 ? 155.144 145.677 159.753 1.00 27.97  ? 497 GLN A N     1 
ATOM   4170 C  CA    . GLN A 1 507 ? 153.833 145.934 159.166 1.00 28.25  ? 497 GLN A CA    1 
ATOM   4171 C  C     . GLN A 1 507 ? 153.289 144.692 158.476 1.00 28.26  ? 497 GLN A C     1 
ATOM   4172 O  O     . GLN A 1 507 ? 152.081 144.446 158.487 1.00 29.58  ? 497 GLN A O     1 
ATOM   4173 C  CB    . GLN A 1 507 ? 153.919 147.106 158.187 1.00 28.43  ? 497 GLN A CB    1 
ATOM   4174 C  CG    . GLN A 1 507 ? 152.569 147.608 157.691 1.00 34.60  ? 497 GLN A CG    1 
ATOM   4175 C  CD    . GLN A 1 507 ? 151.624 147.984 158.820 1.00 40.85  ? 497 GLN A CD    1 
ATOM   4176 O  OE1   . GLN A 1 507 ? 151.969 148.769 159.700 1.00 40.50  ? 497 GLN A OE1   1 
ATOM   4177 N  NE2   . GLN A 1 507 ? 150.426 147.417 158.801 1.00 37.27  ? 497 GLN A NE2   1 
ATOM   4178 N  N     . GLN A 1 508 ? 154.169 143.902 157.867 1.00 29.94  ? 498 GLN A N     1 
ATOM   4179 C  CA    . GLN A 1 508 ? 153.767 142.632 157.276 1.00 28.29  ? 498 GLN A CA    1 
ATOM   4180 C  C     . GLN A 1 508 ? 153.215 141.680 158.330 1.00 27.50  ? 498 GLN A C     1 
ATOM   4181 O  O     . GLN A 1 508 ? 152.169 141.046 158.131 1.00 28.90  ? 498 GLN A O     1 
ATOM   4182 C  CB    . GLN A 1 508 ? 154.971 142.023 156.566 1.00 26.46  ? 498 GLN A CB    1 
ATOM   4183 C  CG    . GLN A 1 508 ? 154.786 140.638 156.040 1.00 23.98  ? 498 GLN A CG    1 
ATOM   4184 C  CD    . GLN A 1 508 ? 155.970 140.211 155.225 1.00 26.22  ? 498 GLN A CD    1 
ATOM   4185 O  OE1   . GLN A 1 508 ? 156.515 140.992 154.452 1.00 24.58  ? 498 GLN A OE1   1 
ATOM   4186 N  NE2   . GLN A 1 508 ? 156.396 138.975 155.409 1.00 33.84  ? 498 GLN A NE2   1 
ATOM   4187 N  N     . ASP A 1 509 ? 153.903 141.575 159.468 1.00 27.06  ? 499 ASP A N     1 
ATOM   4188 C  CA    . ASP A 1 509 ? 153.389 140.735 160.548 1.00 24.87  ? 499 ASP A CA    1 
ATOM   4189 C  C     . ASP A 1 509 ? 152.051 141.253 161.066 1.00 29.17  ? 499 ASP A C     1 
ATOM   4190 O  O     . ASP A 1 509 ? 151.136 140.467 161.344 1.00 30.96  ? 499 ASP A O     1 
ATOM   4191 C  CB    . ASP A 1 509 ? 154.404 140.644 161.684 1.00 25.67  ? 499 ASP A CB    1 
ATOM   4192 C  CG    . ASP A 1 509 ? 155.778 140.234 161.210 1.00 33.32  ? 499 ASP A CG    1 
ATOM   4193 O  OD1   . ASP A 1 509 ? 155.886 139.259 160.440 1.00 32.98  ? 499 ASP A OD1   1 
ATOM   4194 O  OD2   . ASP A 1 509 ? 156.763 140.885 161.614 1.00 35.77  ? 499 ASP A OD2   1 
ATOM   4195 N  N     . ILE A 1 510 ? 151.918 142.574 161.201 1.00 25.76  ? 500 ILE A N     1 
ATOM   4196 C  CA    . ILE A 1 510 ? 150.671 143.163 161.688 1.00 25.47  ? 500 ILE A CA    1 
ATOM   4197 C  C     . ILE A 1 510 ? 149.529 142.851 160.733 1.00 26.63  ? 500 ILE A C     1 
ATOM   4198 O  O     . ILE A 1 510 ? 148.424 142.478 161.150 1.00 27.88  ? 500 ILE A O     1 
ATOM   4199 C  CB    . ILE A 1 510 ? 150.834 144.682 161.876 1.00 28.71  ? 500 ILE A CB    1 
ATOM   4200 C  CG1   . ILE A 1 510 ? 151.676 144.991 163.112 1.00 20.88  ? 500 ILE A CG1   1 
ATOM   4201 C  CG2   . ILE A 1 510 ? 149.480 145.354 161.970 1.00 30.62  ? 500 ILE A CG2   1 
ATOM   4202 C  CD1   . ILE A 1 510 ? 152.111 146.428 163.190 1.00 22.93  ? 500 ILE A CD1   1 
ATOM   4203 N  N     . ASN A 1 511 ? 149.782 143.013 159.432 1.00 26.10  ? 501 ASN A N     1 
ATOM   4204 C  CA    . ASN A 1 511 ? 148.770 142.739 158.423 1.00 22.60  ? 501 ASN A CA    1 
ATOM   4205 C  C     . ASN A 1 511 ? 148.338 141.284 158.467 1.00 22.26  ? 501 ASN A C     1 
ATOM   4206 O  O     . ASN A 1 511 ? 147.142 140.981 158.394 1.00 31.61  ? 501 ASN A O     1 
ATOM   4207 C  CB    . ASN A 1 511 ? 149.313 143.095 157.041 1.00 22.83  ? 501 ASN A CB    1 
ATOM   4208 C  CG    . ASN A 1 511 ? 149.382 144.589 156.809 1.00 28.94  ? 501 ASN A CG    1 
ATOM   4209 O  OD1   . ASN A 1 511 ? 148.958 145.378 157.646 1.00 31.72  ? 501 ASN A OD1   1 
ATOM   4210 N  ND2   . ASN A 1 511 ? 149.923 144.983 155.667 1.00 31.09  ? 501 ASN A ND2   1 
ATOM   4211 N  N     . GLY A 1 512 ? 149.296 140.369 158.607 1.00 21.59  ? 502 GLY A N     1 
ATOM   4212 C  CA    . GLY A 1 512 ? 148.942 138.964 158.691 1.00 22.51  ? 502 GLY A CA    1 
ATOM   4213 C  C     . GLY A 1 512 ? 148.112 138.630 159.914 1.00 23.84  ? 502 GLY A C     1 
ATOM   4214 O  O     . GLY A 1 512 ? 147.132 137.885 159.826 1.00 25.82  ? 502 GLY A O     1 
ATOM   4215 N  N     . CYS A 1 513 ? 148.500 139.159 161.077 1.00 22.04  ? 503 CYS A N     1 
ATOM   4216 C  CA    . CYS A 1 513 ? 147.747 138.865 162.295 1.00 23.60  ? 503 CYS A CA    1 
ATOM   4217 C  C     . CYS A 1 513 ? 146.336 139.436 162.229 1.00 29.73  ? 503 CYS A C     1 
ATOM   4218 O  O     . CYS A 1 513 ? 145.376 138.788 162.667 1.00 32.58  ? 503 CYS A O     1 
ATOM   4219 C  CB    . CYS A 1 513 ? 148.484 139.395 163.522 1.00 26.75  ? 503 CYS A CB    1 
ATOM   4220 S  SG    . CYS A 1 513 ? 150.185 138.819 163.700 1.00 38.47  ? 503 CYS A SG    1 
ATOM   4221 N  N     . LEU A 1 514 ? 146.184 140.646 161.685 1.00 31.82  ? 504 LEU A N     1 
ATOM   4222 C  CA    . LEU A 1 514 ? 144.848 141.211 161.535 1.00 26.90  ? 504 LEU A CA    1 
ATOM   4223 C  C     . LEU A 1 514 ? 144.011 140.404 160.557 1.00 23.42  ? 504 LEU A C     1 
ATOM   4224 O  O     . LEU A 1 514 ? 142.812 140.207 160.778 1.00 31.60  ? 504 LEU A O     1 
ATOM   4225 C  CB    . LEU A 1 514 ? 144.928 142.668 161.096 1.00 25.55  ? 504 LEU A CB    1 
ATOM   4226 C  CG    . LEU A 1 514 ? 144.810 143.655 162.253 1.00 32.55  ? 504 LEU A CG    1 
ATOM   4227 C  CD1   . LEU A 1 514 ? 144.875 145.055 161.727 1.00 32.32  ? 504 LEU A CD1   1 
ATOM   4228 C  CD2   . LEU A 1 514 ? 143.524 143.435 163.039 1.00 28.90  ? 504 LEU A CD2   1 
ATOM   4229 N  N     . LYS A 1 515 ? 144.621 139.930 159.468 1.00 21.33  ? 505 LYS A N     1 
ATOM   4230 C  CA    . LYS A 1 515 ? 143.908 139.043 158.556 1.00 27.88  ? 505 LYS A CA    1 
ATOM   4231 C  C     . LYS A 1 515 ? 143.437 137.785 159.270 1.00 32.81  ? 505 LYS A C     1 
ATOM   4232 O  O     . LYS A 1 515 ? 142.314 137.325 159.052 1.00 35.25  ? 505 LYS A O     1 
ATOM   4233 C  CB    . LYS A 1 515 ? 144.798 138.672 157.373 1.00 27.95  ? 505 LYS A CB    1 
ATOM   4234 C  CG    . LYS A 1 515 ? 144.914 139.738 156.306 1.00 30.89  ? 505 LYS A CG    1 
ATOM   4235 C  CD    . LYS A 1 515 ? 145.586 139.183 155.069 1.00 33.44  ? 505 LYS A CD    1 
ATOM   4236 C  CE    . LYS A 1 515 ? 145.026 137.821 154.715 1.00 41.21  ? 505 LYS A CE    1 
ATOM   4237 N  NZ    . LYS A 1 515 ? 145.716 137.204 153.553 1.00 43.74  ? 505 LYS A NZ    1 
ATOM   4238 N  N     . ASN A 1 516 ? 144.287 137.209 160.119 1.00 30.70  ? 506 ASN A N     1 
ATOM   4239 C  CA    . ASN A 1 516 ? 143.894 136.012 160.858 1.00 25.96  ? 506 ASN A CA    1 
ATOM   4240 C  C     . ASN A 1 516 ? 142.722 136.288 161.789 1.00 24.34  ? 506 ASN A C     1 
ATOM   4241 O  O     . ASN A 1 516 ? 141.789 135.483 161.879 1.00 27.73  ? 506 ASN A O     1 
ATOM   4242 C  CB    . ASN A 1 516 ? 145.080 135.477 161.651 1.00 27.73  ? 506 ASN A CB    1 
ATOM   4243 C  CG    . ASN A 1 516 ? 145.995 134.620 160.819 1.00 27.11  ? 506 ASN A CG    1 
ATOM   4244 O  OD1   . ASN A 1 516 ? 145.541 133.777 160.049 1.00 28.36  ? 506 ASN A OD1   1 
ATOM   4245 N  ND2   . ASN A 1 516 ? 147.294 134.827 160.969 1.00 21.80  ? 506 ASN A ND2   1 
ATOM   4246 N  N     . ILE A 1 517 ? 142.754 137.420 162.495 1.00 24.49  ? 507 ILE A N     1 
ATOM   4247 C  CA    . ILE A 1 517 ? 141.655 137.766 163.397 1.00 26.99  ? 507 ILE A CA    1 
ATOM   4248 C  C     . ILE A 1 517 ? 140.362 137.969 162.615 1.00 24.90  ? 507 ILE A C     1 
ATOM   4249 O  O     . ILE A 1 517 ? 139.288 137.507 163.024 1.00 25.37  ? 507 ILE A O     1 
ATOM   4250 C  CB    . ILE A 1 517 ? 142.017 139.013 164.226 1.00 31.48  ? 507 ILE A CB    1 
ATOM   4251 C  CG1   . ILE A 1 517 ? 143.264 138.754 165.071 1.00 22.86  ? 507 ILE A CG1   1 
ATOM   4252 C  CG2   . ILE A 1 517 ? 140.852 139.428 165.109 1.00 28.89  ? 507 ILE A CG2   1 
ATOM   4253 C  CD1   . ILE A 1 517 ? 143.845 139.993 165.682 1.00 18.13  ? 507 ILE A CD1   1 
ATOM   4254 N  N     . ILE A 1 518 ? 140.445 138.672 161.485 1.00 27.57  ? 508 ILE A N     1 
ATOM   4255 C  CA    . ILE A 1 518 ? 139.268 138.919 160.659 1.00 27.89  ? 508 ILE A CA    1 
ATOM   4256 C  C     . ILE A 1 518 ? 138.699 137.609 160.135 1.00 27.49  ? 508 ILE A C     1 
ATOM   4257 O  O     . ILE A 1 518 ? 137.480 137.401 160.132 1.00 37.02  ? 508 ILE A O     1 
ATOM   4258 C  CB    . ILE A 1 518 ? 139.622 139.889 159.517 1.00 27.80  ? 508 ILE A CB    1 
ATOM   4259 C  CG1   . ILE A 1 518 ? 139.799 141.302 160.065 1.00 25.41  ? 508 ILE A CG1   1 
ATOM   4260 C  CG2   . ILE A 1 518 ? 138.560 139.876 158.442 1.00 33.86  ? 508 ILE A CG2   1 
ATOM   4261 C  CD1   . ILE A 1 518 ? 140.261 142.295 159.040 1.00 33.20  ? 508 ILE A CD1   1 
ATOM   4262 N  N     . ASN A 1 519 ? 139.569 136.707 159.684 1.00 27.33  ? 509 ASN A N     1 
ATOM   4263 C  CA    . ASN A 1 519 ? 139.112 135.397 159.239 1.00 31.51  ? 509 ASN A CA    1 
ATOM   4264 C  C     . ASN A 1 519 ? 138.432 134.643 160.369 1.00 32.26  ? 509 ASN A C     1 
ATOM   4265 O  O     . ASN A 1 519 ? 137.417 133.977 160.153 1.00 40.05  ? 509 ASN A O     1 
ATOM   4266 C  CB    . ASN A 1 519 ? 140.284 134.585 158.697 1.00 31.50  ? 509 ASN A CB    1 
ATOM   4267 C  CG    . ASN A 1 519 ? 140.908 135.211 157.482 1.00 36.20  ? 509 ASN A CG    1 
ATOM   4268 O  OD1   . ASN A 1 519 ? 140.556 136.320 157.092 1.00 38.16  ? 509 ASN A OD1   1 
ATOM   4269 N  ND2   . ASN A 1 519 ? 141.846 134.505 156.874 1.00 37.82  ? 509 ASN A ND2   1 
ATOM   4270 N  N     . TYR A 1 520 ? 138.982 134.731 161.578 1.00 27.04  ? 510 TYR A N     1 
ATOM   4271 C  CA    . TYR A 1 520 ? 138.372 134.079 162.732 1.00 29.68  ? 510 TYR A CA    1 
ATOM   4272 C  C     . TYR A 1 520 ? 136.954 134.592 162.973 1.00 31.93  ? 510 TYR A C     1 
ATOM   4273 O  O     . TYR A 1 520 ? 136.016 133.803 163.154 1.00 31.75  ? 510 TYR A O     1 
ATOM   4274 C  CB    . TYR A 1 520 ? 139.267 134.299 163.955 1.00 26.93  ? 510 TYR A CB    1 
ATOM   4275 C  CG    . TYR A 1 520 ? 138.703 133.845 165.272 1.00 20.74  ? 510 TYR A CG    1 
ATOM   4276 C  CD1   . TYR A 1 520 ? 138.719 132.511 165.628 1.00 24.41  ? 510 TYR A CD1   1 
ATOM   4277 C  CD2   . TYR A 1 520 ? 138.188 134.755 166.175 1.00 20.39  ? 510 TYR A CD2   1 
ATOM   4278 C  CE1   . TYR A 1 520 ? 138.213 132.090 166.831 1.00 26.69  ? 510 TYR A CE1   1 
ATOM   4279 C  CE2   . TYR A 1 520 ? 137.683 134.345 167.383 1.00 22.43  ? 510 TYR A CE2   1 
ATOM   4280 C  CZ    . TYR A 1 520 ? 137.703 133.010 167.708 1.00 25.04  ? 510 TYR A CZ    1 
ATOM   4281 O  OH    . TYR A 1 520 ? 137.195 132.587 168.907 1.00 31.50  ? 510 TYR A OH    1 
ATOM   4282 N  N     . ILE A 1 521 ? 136.779 135.917 162.963 1.00 32.52  ? 511 ILE A N     1 
ATOM   4283 C  CA    . ILE A 1 521 ? 135.456 136.506 163.181 1.00 28.10  ? 511 ILE A CA    1 
ATOM   4284 C  C     . ILE A 1 521 ? 134.490 136.056 162.096 1.00 32.49  ? 511 ILE A C     1 
ATOM   4285 O  O     . ILE A 1 521 ? 133.357 135.627 162.371 1.00 38.05  ? 511 ILE A O     1 
ATOM   4286 C  CB    . ILE A 1 521 ? 135.543 138.041 163.215 1.00 25.03  ? 511 ILE A CB    1 
ATOM   4287 C  CG1   . ILE A 1 521 ? 136.567 138.525 164.231 1.00 28.74  ? 511 ILE A CG1   1 
ATOM   4288 C  CG2   . ILE A 1 521 ? 134.180 138.642 163.504 1.00 33.90  ? 511 ILE A CG2   1 
ATOM   4289 C  CD1   . ILE A 1 521 ? 136.784 140.004 164.170 1.00 26.41  ? 511 ILE A CD1   1 
ATOM   4290 N  N     . TYR A 1 522 ? 134.924 136.167 160.840 1.00 31.47  ? 512 TYR A N     1 
ATOM   4291 C  CA    . TYR A 1 522 ? 134.057 135.827 159.724 1.00 33.83  ? 512 TYR A CA    1 
ATOM   4292 C  C     . TYR A 1 522 ? 133.647 134.367 159.774 1.00 37.82  ? 512 TYR A C     1 
ATOM   4293 O  O     . TYR A 1 522 ? 132.482 134.040 159.538 1.00 48.28  ? 512 TYR A O     1 
ATOM   4294 C  CB    . TYR A 1 522 ? 134.749 136.144 158.402 1.00 41.32  ? 512 TYR A CB    1 
ATOM   4295 C  CG    . TYR A 1 522 ? 133.915 135.791 157.195 1.00 51.81  ? 512 TYR A CG    1 
ATOM   4296 C  CD1   . TYR A 1 522 ? 132.808 136.549 156.849 1.00 51.42  ? 512 TYR A CD1   1 
ATOM   4297 C  CD2   . TYR A 1 522 ? 134.222 134.689 156.414 1.00 52.45  ? 512 TYR A CD2   1 
ATOM   4298 C  CE1   . TYR A 1 522 ? 132.037 136.225 155.754 1.00 53.44  ? 512 TYR A CE1   1 
ATOM   4299 C  CE2   . TYR A 1 522 ? 133.457 134.359 155.322 1.00 53.15  ? 512 TYR A CE2   1 
ATOM   4300 C  CZ    . TYR A 1 522 ? 132.367 135.130 154.996 1.00 53.39  ? 512 TYR A CZ    1 
ATOM   4301 O  OH    . TYR A 1 522 ? 131.604 134.803 153.903 1.00 63.76  ? 512 TYR A OH    1 
ATOM   4302 N  N     . LYS A 1 523 ? 134.578 133.474 160.087 1.00 34.96  ? 513 LYS A N     1 
ATOM   4303 C  CA    . LYS A 1 523 ? 134.242 132.061 160.108 1.00 37.10  ? 513 LYS A CA    1 
ATOM   4304 C  C     . LYS A 1 523 ? 133.411 131.663 161.316 1.00 37.48  ? 513 LYS A C     1 
ATOM   4305 O  O     . LYS A 1 523 ? 132.639 130.708 161.213 1.00 45.24  ? 513 LYS A O     1 
ATOM   4306 C  CB    . LYS A 1 523 ? 135.511 131.215 160.030 1.00 33.95  ? 513 LYS A CB    1 
ATOM   4307 C  CG    . LYS A 1 523 ? 136.273 131.445 158.743 1.00 30.76  ? 513 LYS A CG    1 
ATOM   4308 C  CD    . LYS A 1 523 ? 137.233 130.326 158.428 1.00 33.36  ? 513 LYS A CD    1 
ATOM   4309 C  CE    . LYS A 1 523 ? 137.692 130.415 156.984 1.00 33.47  ? 513 LYS A CE    1 
ATOM   4310 N  NZ    . LYS A 1 523 ? 138.224 129.117 156.492 1.00 37.85  ? 513 LYS A NZ    1 
ATOM   4311 N  N     . ILE A 1 524 ? 133.520 132.362 162.445 1.00 39.30  ? 514 ILE A N     1 
ATOM   4312 C  CA    . ILE A 1 524 ? 132.566 132.109 163.522 1.00 44.30  ? 514 ILE A CA    1 
ATOM   4313 C  C     . ILE A 1 524 ? 131.165 132.507 163.099 1.00 46.57  ? 514 ILE A C     1 
ATOM   4314 O  O     . ILE A 1 524 ? 130.206 131.751 163.287 1.00 49.06  ? 514 ILE A O     1 
ATOM   4315 C  CB    . ILE A 1 524 ? 132.967 132.832 164.817 1.00 41.29  ? 514 ILE A CB    1 
ATOM   4316 C  CG1   . ILE A 1 524 ? 134.276 132.295 165.358 1.00 32.56  ? 514 ILE A CG1   1 
ATOM   4317 C  CG2   . ILE A 1 524 ? 131.871 132.708 165.867 1.00 41.91  ? 514 ILE A CG2   1 
ATOM   4318 C  CD1   . ILE A 1 524 ? 134.758 133.129 166.452 1.00 36.12  ? 514 ILE A CD1   1 
ATOM   4319 N  N     . PHE A 1 525 ? 131.018 133.702 162.529 1.00 47.66  ? 515 PHE A N     1 
ATOM   4320 C  CA    . PHE A 1 525 ? 129.676 134.131 162.156 1.00 43.66  ? 515 PHE A CA    1 
ATOM   4321 C  C     . PHE A 1 525 ? 129.122 133.304 161.004 1.00 47.49  ? 515 PHE A C     1 
ATOM   4322 O  O     . PHE A 1 525 ? 127.907 133.111 160.911 1.00 56.50  ? 515 PHE A O     1 
ATOM   4323 C  CB    . PHE A 1 525 ? 129.675 135.620 161.829 1.00 37.99  ? 515 PHE A CB    1 
ATOM   4324 C  CG    . PHE A 1 525 ? 129.657 136.491 163.049 1.00 43.18  ? 515 PHE A CG    1 
ATOM   4325 C  CD1   . PHE A 1 525 ? 128.628 136.385 163.967 1.00 44.20  ? 515 PHE A CD1   1 
ATOM   4326 C  CD2   . PHE A 1 525 ? 130.673 137.395 163.290 1.00 38.39  ? 515 PHE A CD2   1 
ATOM   4327 C  CE1   . PHE A 1 525 ? 128.608 137.169 165.094 1.00 41.27  ? 515 PHE A CE1   1 
ATOM   4328 C  CE2   . PHE A 1 525 ? 130.656 138.185 164.416 1.00 36.72  ? 515 PHE A CE2   1 
ATOM   4329 C  CZ    . PHE A 1 525 ? 129.623 138.072 165.318 1.00 39.26  ? 515 PHE A CZ    1 
ATOM   4330 N  N     . GLU A 1 526 ? 129.992 132.790 160.136 1.00 44.40  ? 516 GLU A N     1 
ATOM   4331 C  CA    . GLU A 1 526 ? 129.552 131.937 159.040 1.00 46.53  ? 516 GLU A CA    1 
ATOM   4332 C  C     . GLU A 1 526 ? 129.143 130.558 159.537 1.00 50.80  ? 516 GLU A C     1 
ATOM   4333 O  O     . GLU A 1 526 ? 128.101 130.029 159.138 1.00 56.61  ? 516 GLU A O     1 
ATOM   4334 C  CB    . GLU A 1 526 ? 130.665 131.825 158.004 1.00 51.22  ? 516 GLU A CB    1 
ATOM   4335 C  CG    . GLU A 1 526 ? 130.389 130.860 156.872 1.00 59.78  ? 516 GLU A CG    1 
ATOM   4336 C  CD    . GLU A 1 526 ? 131.533 130.811 155.879 1.00 64.96  ? 516 GLU A CD    1 
ATOM   4337 O  OE1   . GLU A 1 526 ? 132.624 131.319 156.208 1.00 58.09  ? 516 GLU A OE1   1 
ATOM   4338 O  OE2   . GLU A 1 526 ? 131.342 130.269 154.772 1.00 65.56  ? 516 GLU A OE2   1 
ATOM   4339 N  N     . GLN A 1 527 ? 129.948 129.957 160.411 1.00 48.70  ? 517 GLN A N     1 
ATOM   4340 C  CA    . GLN A 1 527 ? 129.697 128.601 160.881 1.00 45.81  ? 517 GLN A CA    1 
ATOM   4341 C  C     . GLN A 1 527 ? 128.621 128.528 161.950 1.00 48.40  ? 517 GLN A C     1 
ATOM   4342 O  O     . GLN A 1 527 ? 128.459 127.475 162.571 1.00 49.54  ? 517 GLN A O     1 
ATOM   4343 C  CB    . GLN A 1 527 ? 130.990 127.981 161.410 1.00 43.80  ? 517 GLN A CB    1 
ATOM   4344 C  CG    . GLN A 1 527 ? 131.996 127.642 160.328 1.00 53.56  ? 517 GLN A CG    1 
ATOM   4345 C  CD    . GLN A 1 527 ? 132.987 126.587 160.768 1.00 63.19  ? 517 GLN A CD    1 
ATOM   4346 O  OE1   . GLN A 1 527 ? 133.079 126.261 161.950 1.00 64.31  ? 517 GLN A OE1   1 
ATOM   4347 N  NE2   . GLN A 1 527 ? 133.731 126.041 159.815 1.00 54.71  ? 517 GLN A NE2   1 
ATOM   4348 N  N     . ASN A 1 528 ? 127.888 129.613 162.182 1.00 50.89  ? 518 ASN A N     1 
ATOM   4349 C  CA    . ASN A 1 528 ? 126.841 129.645 163.189 1.00 51.73  ? 518 ASN A CA    1 
ATOM   4350 C  C     . ASN A 1 528 ? 125.479 129.994 162.616 1.00 52.90  ? 518 ASN A C     1 
ATOM   4351 O  O     . ASN A 1 528 ? 124.494 129.995 163.361 1.00 53.45  ? 518 ASN A O     1 
ATOM   4352 C  CB    . ASN A 1 528 ? 127.200 130.643 164.296 1.00 51.05  ? 518 ASN A CB    1 
ATOM   4353 C  CG    . ASN A 1 528 ? 128.075 130.034 165.363 1.00 46.99  ? 518 ASN A CG    1 
ATOM   4354 O  OD1   . ASN A 1 528 ? 127.642 129.160 166.111 1.00 47.81  ? 518 ASN A OD1   1 
ATOM   4355 N  ND2   . ASN A 1 528 ? 129.318 130.485 165.435 1.00 49.12  ? 518 ASN A ND2   1 
ATOM   4356 N  N     . GLY A 1 529 ? 125.393 130.294 161.323 1.00 50.01  ? 519 GLY A N     1 
ATOM   4357 C  CA    . GLY A 1 529 ? 124.138 130.561 160.660 1.00 56.52  ? 519 GLY A CA    1 
ATOM   4358 C  C     . GLY A 1 529 ? 123.956 131.989 160.197 1.00 65.94  ? 519 GLY A C     1 
ATOM   4359 O  O     . GLY A 1 529 ? 123.056 132.247 159.391 1.00 74.12  ? 519 GLY A O     1 
ATOM   4360 N  N     . TYR A 1 530 ? 124.775 132.923 160.672 1.00 62.53  ? 520 TYR A N     1 
ATOM   4361 C  CA    . TYR A 1 530 ? 124.592 134.326 160.320 1.00 57.39  ? 520 TYR A CA    1 
ATOM   4362 C  C     . TYR A 1 530 ? 124.833 134.519 158.831 1.00 60.96  ? 520 TYR A C     1 
ATOM   4363 O  O     . TYR A 1 530 ? 125.940 134.287 158.340 1.00 66.11  ? 520 TYR A O     1 
ATOM   4364 C  CB    . TYR A 1 530 ? 125.526 135.210 161.140 1.00 50.41  ? 520 TYR A CB    1 
ATOM   4365 C  CG    . TYR A 1 530 ? 125.141 135.292 162.598 1.00 52.40  ? 520 TYR A CG    1 
ATOM   4366 C  CD1   . TYR A 1 530 ? 125.319 134.211 163.447 1.00 51.40  ? 520 TYR A CD1   1 
ATOM   4367 C  CD2   . TYR A 1 530 ? 124.583 136.446 163.119 1.00 52.91  ? 520 TYR A CD2   1 
ATOM   4368 C  CE1   . TYR A 1 530 ? 124.960 134.284 164.774 1.00 51.83  ? 520 TYR A CE1   1 
ATOM   4369 C  CE2   . TYR A 1 530 ? 124.222 136.527 164.445 1.00 55.23  ? 520 TYR A CE2   1 
ATOM   4370 C  CZ    . TYR A 1 530 ? 124.413 135.445 165.267 1.00 55.18  ? 520 TYR A CZ    1 
ATOM   4371 O  OH    . TYR A 1 530 ? 124.052 135.528 166.587 1.00 59.32  ? 520 TYR A OH    1 
ATOM   4372 N  N     . LYS A 1 531 ? 123.792 134.931 158.112 1.00 67.68  ? 521 LYS A N     1 
ATOM   4373 C  CA    . LYS A 1 531 ? 123.849 135.026 156.661 1.00 69.88  ? 521 LYS A CA    1 
ATOM   4374 C  C     . LYS A 1 531 ? 124.219 136.413 156.161 1.00 63.99  ? 521 LYS A C     1 
ATOM   4375 O  O     . LYS A 1 531 ? 124.494 136.565 154.968 1.00 65.70  ? 521 LYS A O     1 
ATOM   4376 C  CB    . LYS A 1 531 ? 122.509 134.595 156.053 1.00 75.71  ? 521 LYS A CB    1 
ATOM   4377 C  CG    . LYS A 1 531 ? 122.173 133.132 156.308 1.00 80.17  ? 521 LYS A CG    1 
ATOM   4378 C  CD    . LYS A 1 531 ? 123.361 132.225 156.025 1.00 75.92  ? 521 LYS A CD    1 
ATOM   4379 C  CE    . LYS A 1 531 ? 123.139 130.824 156.568 1.00 76.12  ? 521 LYS A CE    1 
ATOM   4380 N  NZ    . LYS A 1 531 ? 124.352 129.971 156.441 1.00 70.79  ? 521 LYS A NZ    1 
ATOM   4381 N  N     . ILE A 1 532 ? 124.228 137.419 157.031 1.00 62.33  ? 522 ILE A N     1 
ATOM   4382 C  CA    . ILE A 1 532 ? 124.807 138.725 156.729 1.00 66.07  ? 522 ILE A CA    1 
ATOM   4383 C  C     . ILE A 1 532 ? 125.569 139.202 157.956 1.00 62.21  ? 522 ILE A C     1 
ATOM   4384 O  O     . ILE A 1 532 ? 125.076 139.083 159.082 1.00 61.71  ? 522 ILE A O     1 
ATOM   4385 C  CB    . ILE A 1 532 ? 123.749 139.771 156.317 1.00 62.56  ? 522 ILE A CB    1 
ATOM   4386 C  CG1   . ILE A 1 532 ? 123.059 139.378 155.010 1.00 63.44  ? 522 ILE A CG1   1 
ATOM   4387 C  CG2   . ILE A 1 532 ? 124.373 141.143 156.173 1.00 59.98  ? 522 ILE A CG2   1 
ATOM   4388 C  CD1   . ILE A 1 532 ? 121.850 140.226 154.681 1.00 61.82  ? 522 ILE A CD1   1 
ATOM   4389 N  N     . VAL A 1 533 ? 126.775 139.721 157.744 1.00 58.17  ? 523 VAL A N     1 
ATOM   4390 C  CA    . VAL A 1 533 ? 127.478 140.457 158.785 1.00 56.09  ? 523 VAL A CA    1 
ATOM   4391 C  C     . VAL A 1 533 ? 127.543 141.915 158.357 1.00 60.69  ? 523 VAL A C     1 
ATOM   4392 O  O     . VAL A 1 533 ? 128.467 142.327 157.649 1.00 62.17  ? 523 VAL A O     1 
ATOM   4393 C  CB    . VAL A 1 533 ? 128.882 139.885 159.039 1.00 59.84  ? 523 VAL A CB    1 
ATOM   4394 C  CG1   . VAL A 1 533 ? 129.591 140.677 160.121 1.00 58.89  ? 523 VAL A CG1   1 
ATOM   4395 C  CG2   . VAL A 1 533 ? 128.788 138.426 159.430 1.00 61.05  ? 523 VAL A CG2   1 
ATOM   4396 N  N     . ALA A 1 534 ? 126.558 142.702 158.776 1.00 63.79  ? 524 ALA A N     1 
ATOM   4397 C  CA    . ALA A 1 534 ? 126.473 144.109 158.392 1.00 63.77  ? 524 ALA A CA    1 
ATOM   4398 C  C     . ALA A 1 534 ? 127.530 144.894 159.153 1.00 65.26  ? 524 ALA A C     1 
ATOM   4399 O  O     . ALA A 1 534 ? 127.341 145.248 160.317 1.00 69.52  ? 524 ALA A O     1 
ATOM   4400 C  CB    . ALA A 1 534 ? 125.077 144.653 158.668 1.00 59.93  ? 524 ALA A CB    1 
ATOM   4401 N  N     . LEU A 1 535 ? 128.649 145.176 158.497 1.00 62.15  ? 525 LEU A N     1 
ATOM   4402 C  CA    . LEU A 1 535 ? 129.734 145.929 159.116 1.00 64.67  ? 525 LEU A CA    1 
ATOM   4403 C  C     . LEU A 1 535 ? 129.297 147.379 159.270 1.00 70.00  ? 525 LEU A C     1 
ATOM   4404 O  O     . LEU A 1 535 ? 129.355 148.163 158.321 1.00 72.22  ? 525 LEU A O     1 
ATOM   4405 C  CB    . LEU A 1 535 ? 131.000 145.817 158.277 1.00 61.69  ? 525 LEU A CB    1 
ATOM   4406 C  CG    . LEU A 1 535 ? 132.287 146.399 158.865 1.00 64.22  ? 525 LEU A CG    1 
ATOM   4407 C  CD1   . LEU A 1 535 ? 132.464 146.016 160.321 1.00 59.25  ? 525 LEU A CD1   1 
ATOM   4408 C  CD2   . LEU A 1 535 ? 133.469 145.937 158.064 1.00 59.02  ? 525 LEU A CD2   1 
ATOM   4409 N  N     . GLU A 1 536 ? 128.860 147.740 160.475 1.00 67.43  ? 526 GLU A N     1 
ATOM   4410 C  CA    . GLU A 1 536 ? 128.376 149.087 160.755 1.00 72.03  ? 526 GLU A CA    1 
ATOM   4411 C  C     . GLU A 1 536 ? 129.469 150.129 160.557 1.00 77.91  ? 526 GLU A C     1 
ATOM   4412 O  O     . GLU A 1 536 ? 130.438 150.175 161.322 1.00 78.97  ? 526 GLU A O     1 
ATOM   4413 C  CB    . GLU A 1 536 ? 127.833 149.164 162.182 1.00 73.90  ? 526 GLU A CB    1 
ATOM   4414 C  CG    . GLU A 1 536 ? 127.243 150.507 162.554 1.00 79.31  ? 526 GLU A CG    1 
ATOM   4415 C  CD    . GLU A 1 536 ? 126.751 150.540 163.986 1.00 82.94  ? 526 GLU A CD    1 
ATOM   4416 O  OE1   . GLU A 1 536 ? 126.945 149.535 164.700 1.00 82.63  ? 526 GLU A OE1   1 
ATOM   4417 O  OE2   . GLU A 1 536 ? 126.172 151.568 164.400 1.00 78.54  ? 526 GLU A OE2   1 
ATOM   4418 N  N     . ASN A 1 537 ? 129.318 150.972 159.541 1.00 77.75  ? 527 ASN A N     1 
ATOM   4419 C  CA    . ASN A 1 537 ? 130.297 152.010 159.252 1.00 79.42  ? 527 ASN A CA    1 
ATOM   4420 C  C     . ASN A 1 537 ? 130.298 153.086 160.330 1.00 79.89  ? 527 ASN A C     1 
ATOM   4421 O  O     . ASN A 1 537 ? 131.351 153.447 160.857 1.00 81.38  ? 527 ASN A O     1 
ATOM   4422 C  CB    . ASN A 1 537 ? 130.023 152.637 157.885 1.00 78.50  ? 527 ASN A CB    1 
ATOM   4423 C  CG    . ASN A 1 537 ? 130.682 151.875 156.758 1.00 80.57  ? 527 ASN A CG    1 
ATOM   4424 O  OD1   . ASN A 1 537 ? 130.966 150.683 156.885 1.00 77.77  ? 527 ASN A OD1   1 
ATOM   4425 N  ND2   . ASN A 1 537 ? 130.934 152.558 155.647 1.00 76.34  ? 527 ASN A ND2   1 
ATOM   4426 N  N     . PHE A 1 543 ? 136.802 157.304 165.868 1.00 84.05  ? 533 PHE A N     1 
ATOM   4427 C  CA    . PHE A 1 543 ? 137.881 158.140 165.355 1.00 82.13  ? 533 PHE A CA    1 
ATOM   4428 C  C     . PHE A 1 543 ? 137.996 159.426 166.158 1.00 88.58  ? 533 PHE A C     1 
ATOM   4429 O  O     . PHE A 1 543 ? 137.570 160.488 165.707 1.00 88.07  ? 533 PHE A O     1 
ATOM   4430 C  CB    . PHE A 1 543 ? 137.655 158.466 163.878 1.00 82.04  ? 533 PHE A CB    1 
ATOM   4431 C  CG    . PHE A 1 543 ? 138.116 157.388 162.942 1.00 81.50  ? 533 PHE A CG    1 
ATOM   4432 C  CD1   . PHE A 1 543 ? 139.412 156.907 163.005 1.00 80.86  ? 533 PHE A CD1   1 
ATOM   4433 C  CD2   . PHE A 1 543 ? 137.257 156.863 161.994 1.00 72.38  ? 533 PHE A CD2   1 
ATOM   4434 C  CE1   . PHE A 1 543 ? 139.842 155.915 162.142 1.00 77.38  ? 533 PHE A CE1   1 
ATOM   4435 C  CE2   . PHE A 1 543 ? 137.679 155.872 161.130 1.00 69.83  ? 533 PHE A CE2   1 
ATOM   4436 C  CZ    . PHE A 1 543 ? 138.974 155.397 161.204 1.00 74.60  ? 533 PHE A CZ    1 
ATOM   4437 N  N     . GLU A 1 544 ? 138.571 159.329 167.353 1.00 90.44  ? 534 GLU A N     1 
ATOM   4438 C  CA    . GLU A 1 544 ? 138.755 160.474 168.241 1.00 94.20  ? 534 GLU A CA    1 
ATOM   4439 C  C     . GLU A 1 544 ? 140.256 160.710 168.390 1.00 84.48  ? 534 GLU A C     1 
ATOM   4440 O  O     . GLU A 1 544 ? 140.887 160.223 169.330 1.00 79.48  ? 534 GLU A O     1 
ATOM   4441 C  CB    . GLU A 1 544 ? 138.076 160.233 169.589 1.00 100.97 ? 534 GLU A CB    1 
ATOM   4442 C  CG    . GLU A 1 544 ? 136.616 159.822 169.476 1.00 103.68 ? 534 GLU A CG    1 
ATOM   4443 C  CD    . GLU A 1 544 ? 135.938 159.691 170.825 1.00 108.52 ? 534 GLU A CD    1 
ATOM   4444 O  OE1   . GLU A 1 544 ? 136.620 159.860 171.857 1.00 109.60 ? 534 GLU A OE1   1 
ATOM   4445 O  OE2   . GLU A 1 544 ? 134.720 159.421 170.854 1.00 101.28 ? 534 GLU A OE2   1 
ATOM   4446 N  N     . LYS A 1 545 ? 140.820 161.474 167.460 1.00 79.17  ? 535 LYS A N     1 
ATOM   4447 C  CA    . LYS A 1 545 ? 142.257 161.720 167.425 1.00 68.62  ? 535 LYS A CA    1 
ATOM   4448 C  C     . LYS A 1 545 ? 142.678 162.542 168.637 1.00 67.48  ? 535 LYS A C     1 
ATOM   4449 O  O     . LYS A 1 545 ? 142.273 163.700 168.780 1.00 68.30  ? 535 LYS A O     1 
ATOM   4450 C  CB    . LYS A 1 545 ? 142.626 162.439 166.132 1.00 64.99  ? 535 LYS A CB    1 
ATOM   4451 C  CG    . LYS A 1 545 ? 144.056 162.943 166.091 1.00 69.53  ? 535 LYS A CG    1 
ATOM   4452 C  CD    . LYS A 1 545 ? 144.399 163.532 164.738 1.00 70.02  ? 535 LYS A CD    1 
ATOM   4453 C  CE    . LYS A 1 545 ? 144.227 162.512 163.630 1.00 72.16  ? 535 LYS A CE    1 
ATOM   4454 N  NZ    . LYS A 1 545 ? 144.415 163.131 162.290 1.00 65.93  ? 535 LYS A NZ    1 
ATOM   4455 N  N     . LYS A 1 546 ? 143.490 161.950 169.511 1.00 59.77  ? 536 LYS A N     1 
ATOM   4456 C  CA    . LYS A 1 546 ? 144.097 162.719 170.586 1.00 56.10  ? 536 LYS A CA    1 
ATOM   4457 C  C     . LYS A 1 546 ? 145.019 163.776 170.000 1.00 60.82  ? 536 LYS A C     1 
ATOM   4458 O  O     . LYS A 1 546 ? 145.642 163.578 168.955 1.00 65.02  ? 536 LYS A O     1 
ATOM   4459 C  CB    . LYS A 1 546 ? 144.882 161.815 171.533 1.00 44.63  ? 536 LYS A CB    1 
ATOM   4460 C  CG    . LYS A 1 546 ? 144.068 160.738 172.203 1.00 44.33  ? 536 LYS A CG    1 
ATOM   4461 C  CD    . LYS A 1 546 ? 144.917 159.994 173.209 1.00 46.12  ? 536 LYS A CD    1 
ATOM   4462 C  CE    . LYS A 1 546 ? 144.131 158.897 173.889 1.00 49.31  ? 536 LYS A CE    1 
ATOM   4463 N  NZ    . LYS A 1 546 ? 145.015 158.004 174.681 1.00 44.62  ? 536 LYS A NZ    1 
ATOM   4464 N  N     . GLN A 1 547 ? 145.102 164.913 170.680 1.00 60.39  ? 537 GLN A N     1 
ATOM   4465 C  CA    . GLN A 1 547 ? 145.831 166.065 170.171 1.00 65.44  ? 537 GLN A CA    1 
ATOM   4466 C  C     . GLN A 1 547 ? 147.218 166.112 170.793 1.00 61.92  ? 537 GLN A C     1 
ATOM   4467 O  O     . GLN A 1 547 ? 147.359 166.098 172.019 1.00 61.97  ? 537 GLN A O     1 
ATOM   4468 C  CB    . GLN A 1 547 ? 145.071 167.360 170.457 1.00 67.64  ? 537 GLN A CB    1 
ATOM   4469 C  CG    . GLN A 1 547 ? 143.654 167.363 169.914 1.00 75.78  ? 537 GLN A CG    1 
ATOM   4470 C  CD    . GLN A 1 547 ? 143.194 168.740 169.484 1.00 85.36  ? 537 GLN A CD    1 
ATOM   4471 O  OE1   . GLN A 1 547 ? 144.009 169.626 169.225 1.00 90.05  ? 537 GLN A OE1   1 
ATOM   4472 N  NE2   . GLN A 1 547 ? 141.882 168.929 169.403 1.00 86.41  ? 537 GLN A NE2   1 
ATOM   4473 N  N     . VAL A 1 548 ? 148.238 166.164 169.938 1.00 56.08  ? 538 VAL A N     1 
ATOM   4474 C  CA    . VAL A 1 548 ? 149.612 166.211 170.409 1.00 56.53  ? 538 VAL A CA    1 
ATOM   4475 C  C     . VAL A 1 548 ? 149.924 167.619 170.899 1.00 60.28  ? 538 VAL A C     1 
ATOM   4476 O  O     . VAL A 1 548 ? 149.453 168.614 170.333 1.00 62.95  ? 538 VAL A O     1 
ATOM   4477 C  CB    . VAL A 1 548 ? 150.561 165.781 169.276 1.00 52.50  ? 538 VAL A CB    1 
ATOM   4478 C  CG1   . VAL A 1 548 ? 152.016 165.878 169.704 1.00 57.16  ? 538 VAL A CG1   1 
ATOM   4479 C  CG2   . VAL A 1 548 ? 150.212 164.385 168.808 1.00 50.62  ? 538 VAL A CG2   1 
ATOM   4480 N  N     . LEU A 1 549 ? 150.707 167.708 171.970 1.00 52.80  ? 539 LEU A N     1 
ATOM   4481 C  CA    . LEU A 1 549 ? 151.074 169.012 172.499 1.00 56.97  ? 539 LEU A CA    1 
ATOM   4482 C  C     . LEU A 1 549 ? 151.796 169.819 171.424 1.00 62.74  ? 539 LEU A C     1 
ATOM   4483 O  O     . LEU A 1 549 ? 152.618 169.269 170.682 1.00 60.11  ? 539 LEU A O     1 
ATOM   4484 C  CB    . LEU A 1 549 ? 151.971 168.871 173.730 1.00 58.97  ? 539 LEU A CB    1 
ATOM   4485 C  CG    . LEU A 1 549 ? 151.475 168.031 174.906 1.00 63.91  ? 539 LEU A CG    1 
ATOM   4486 C  CD1   . LEU A 1 549 ? 152.598 167.772 175.889 1.00 59.40  ? 539 LEU A CD1   1 
ATOM   4487 C  CD2   . LEU A 1 549 ? 150.323 168.724 175.595 1.00 71.04  ? 539 LEU A CD2   1 
ATOM   4488 N  N     . PRO A 1 550 ? 151.506 171.113 171.300 1.00 60.93  ? 540 PRO A N     1 
ATOM   4489 C  CA    . PRO A 1 550 ? 152.202 171.925 170.296 1.00 60.92  ? 540 PRO A CA    1 
ATOM   4490 C  C     . PRO A 1 550 ? 153.700 171.953 170.550 1.00 62.28  ? 540 PRO A C     1 
ATOM   4491 O  O     . PRO A 1 550 ? 154.154 172.059 171.690 1.00 62.37  ? 540 PRO A O     1 
ATOM   4492 C  CB    . PRO A 1 550 ? 151.567 173.308 170.460 1.00 60.74  ? 540 PRO A CB    1 
ATOM   4493 C  CG    . PRO A 1 550 ? 151.087 173.334 171.868 1.00 59.80  ? 540 PRO A CG    1 
ATOM   4494 C  CD    . PRO A 1 550 ? 150.666 171.930 172.192 1.00 56.16  ? 540 PRO A CD    1 
ATOM   4495 N  N     . THR A 1 551 ? 154.467 171.866 169.466 1.00 63.87  ? 541 THR A N     1 
ATOM   4496 C  CA    . THR A 1 551 ? 155.904 171.682 169.574 1.00 63.67  ? 541 THR A CA    1 
ATOM   4497 C  C     . THR A 1 551 ? 156.568 172.930 170.144 1.00 70.18  ? 541 THR A C     1 
ATOM   4498 O  O     . THR A 1 551 ? 155.961 173.997 170.270 1.00 74.48  ? 541 THR A O     1 
ATOM   4499 C  CB    . THR A 1 551 ? 156.512 171.343 168.214 1.00 62.36  ? 541 THR A CB    1 
ATOM   4500 O  OG1   . THR A 1 551 ? 156.123 172.334 167.257 1.00 69.79  ? 541 THR A OG1   1 
ATOM   4501 C  CG2   . THR A 1 551 ? 156.045 169.979 167.743 1.00 52.08  ? 541 THR A CG2   1 
ATOM   4502 N  N     . ILE A 1 552 ? 157.842 172.776 170.503 1.00 66.24  ? 542 ILE A N     1 
ATOM   4503 C  CA    . ILE A 1 552 ? 158.589 173.884 171.087 1.00 69.48  ? 542 ILE A CA    1 
ATOM   4504 C  C     . ILE A 1 552 ? 158.742 175.014 170.078 1.00 69.33  ? 542 ILE A C     1 
ATOM   4505 O  O     . ILE A 1 552 ? 158.575 176.192 170.415 1.00 71.98  ? 542 ILE A O     1 
ATOM   4506 C  CB    . ILE A 1 552 ? 159.951 173.390 171.601 1.00 68.11  ? 542 ILE A CB    1 
ATOM   4507 C  CG1   . ILE A 1 552 ? 159.745 172.292 172.639 1.00 68.86  ? 542 ILE A CG1   1 
ATOM   4508 C  CG2   . ILE A 1 552 ? 160.746 174.543 172.190 1.00 71.98  ? 542 ILE A CG2   1 
ATOM   4509 C  CD1   . ILE A 1 552 ? 160.993 171.518 172.946 1.00 74.08  ? 542 ILE A CD1   1 
ATOM   4510 N  N     . LYS A 1 553 ? 159.059 174.678 168.825 1.00 65.43  ? 543 LYS A N     1 
ATOM   4511 C  CA    . LYS A 1 553 ? 159.123 175.703 167.789 1.00 63.86  ? 543 LYS A CA    1 
ATOM   4512 C  C     . LYS A 1 553 ? 157.763 176.352 167.588 1.00 63.91  ? 543 LYS A C     1 
ATOM   4513 O  O     . LYS A 1 553 ? 157.667 177.566 167.383 1.00 69.94  ? 543 LYS A O     1 
ATOM   4514 C  CB    . LYS A 1 553 ? 159.634 175.105 166.480 1.00 58.37  ? 543 LYS A CB    1 
ATOM   4515 C  CG    . LYS A 1 553 ? 159.610 176.081 165.321 1.00 54.16  ? 543 LYS A CG    1 
ATOM   4516 C  CD    . LYS A 1 553 ? 160.485 175.606 164.181 1.00 54.74  ? 543 LYS A CD    1 
ATOM   4517 C  CE    . LYS A 1 553 ? 160.521 176.622 163.064 1.00 51.30  ? 543 LYS A CE    1 
ATOM   4518 N  NZ    . LYS A 1 553 ? 161.639 176.344 162.133 1.00 54.46  ? 543 LYS A NZ    1 
ATOM   4519 N  N     . SER A 1 554 ? 156.698 175.554 167.637 1.00 60.86  ? 544 SER A N     1 
ATOM   4520 C  CA    . SER A 1 554 ? 155.358 176.122 167.664 1.00 63.96  ? 544 SER A CA    1 
ATOM   4521 C  C     . SER A 1 554 ? 155.119 176.912 168.941 1.00 68.01  ? 544 SER A C     1 
ATOM   4522 O  O     . SER A 1 554 ? 154.386 177.904 168.927 1.00 72.54  ? 544 SER A O     1 
ATOM   4523 C  CB    . SER A 1 554 ? 154.316 175.015 167.524 1.00 67.77  ? 544 SER A CB    1 
ATOM   4524 O  OG    . SER A 1 554 ? 153.027 175.490 167.867 1.00 72.79  ? 544 SER A OG    1 
ATOM   4525 N  N     . LEU A 1 555 ? 155.717 176.489 170.055 1.00 64.52  ? 545 LEU A N     1 
ATOM   4526 C  CA    . LEU A 1 555 ? 155.518 177.222 171.298 1.00 66.75  ? 545 LEU A CA    1 
ATOM   4527 C  C     . LEU A 1 555 ? 156.212 178.578 171.270 1.00 75.34  ? 545 LEU A C     1 
ATOM   4528 O  O     . LEU A 1 555 ? 155.732 179.527 171.898 1.00 77.62  ? 545 LEU A O     1 
ATOM   4529 C  CB    . LEU A 1 555 ? 156.006 176.399 172.488 1.00 64.23  ? 545 LEU A CB    1 
ATOM   4530 C  CG    . LEU A 1 555 ? 155.493 176.905 173.839 1.00 67.92  ? 545 LEU A CG    1 
ATOM   4531 C  CD1   . LEU A 1 555 ? 154.019 176.592 174.003 1.00 70.38  ? 545 LEU A CD1   1 
ATOM   4532 C  CD2   . LEU A 1 555 ? 156.295 176.335 174.989 1.00 63.12  ? 545 LEU A CD2   1 
ATOM   4533 N  N     . LEU A 1 556 ? 157.329 178.696 170.553 1.00 73.15  ? 546 LEU A N     1 
ATOM   4534 C  CA    . LEU A 1 556 ? 158.072 179.953 170.511 1.00 76.21  ? 546 LEU A CA    1 
ATOM   4535 C  C     . LEU A 1 556 ? 157.671 180.818 169.318 1.00 77.59  ? 546 LEU A C     1 
ATOM   4536 O  O     . LEU A 1 556 ? 157.212 181.951 169.491 1.00 79.85  ? 546 LEU A O     1 
ATOM   4537 C  CB    . LEU A 1 556 ? 159.580 179.680 170.478 1.00 75.97  ? 546 LEU A CB    1 
ATOM   4538 C  CG    . LEU A 1 556 ? 160.193 178.798 171.564 1.00 76.66  ? 546 LEU A CG    1 
ATOM   4539 C  CD1   . LEU A 1 556 ? 161.707 178.913 171.536 1.00 81.99  ? 546 LEU A CD1   1 
ATOM   4540 C  CD2   . LEU A 1 556 ? 159.656 179.165 172.929 1.00 77.57  ? 546 LEU A CD2   1 
ATOM   4541 N  N     . LYS A 1 557 ? 157.841 180.299 168.106 1.00 75.09  ? 547 LYS A N     1 
ATOM   4542 C  CA    . LYS A 1 557 ? 157.646 181.089 166.898 1.00 75.22  ? 547 LYS A CA    1 
ATOM   4543 C  C     . LYS A 1 557 ? 156.189 181.190 166.468 1.00 76.72  ? 547 LYS A C     1 
ATOM   4544 O  O     . LYS A 1 557 ? 155.875 182.002 165.592 1.00 81.02  ? 547 LYS A O     1 
ATOM   4545 C  CB    . LYS A 1 557 ? 158.473 180.505 165.749 1.00 70.79  ? 547 LYS A CB    1 
ATOM   4546 C  CG    . LYS A 1 557 ? 159.873 180.073 166.151 1.00 69.22  ? 547 LYS A CG    1 
ATOM   4547 C  CD    . LYS A 1 557 ? 160.672 181.235 166.711 1.00 73.27  ? 547 LYS A CD    1 
ATOM   4548 C  CE    . LYS A 1 557 ? 161.990 180.763 167.291 1.00 74.18  ? 547 LYS A CE    1 
ATOM   4549 N  NZ    . LYS A 1 557 ? 162.703 181.858 168.000 1.00 79.92  ? 547 LYS A NZ    1 
ATOM   4550 N  N     . TYR A 1 558 ? 155.297 180.399 167.054 1.00 76.00  ? 548 TYR A N     1 
ATOM   4551 C  CA    . TYR A 1 558 ? 153.894 180.398 166.662 1.00 76.71  ? 548 TYR A CA    1 
ATOM   4552 C  C     . TYR A 1 558 ? 152.978 180.867 167.780 1.00 75.65  ? 548 TYR A C     1 
ATOM   4553 O  O     . TYR A 1 558 ? 152.167 181.776 167.568 1.00 74.02  ? 548 TYR A O     1 
ATOM   4554 C  CB    . TYR A 1 558 ? 153.492 178.993 166.187 1.00 72.70  ? 548 TYR A CB    1 
ATOM   4555 C  CG    . TYR A 1 558 ? 152.029 178.831 165.861 1.00 76.22  ? 548 TYR A CG    1 
ATOM   4556 C  CD1   . TYR A 1 558 ? 151.323 179.838 165.218 1.00 78.57  ? 548 TYR A CD1   1 
ATOM   4557 C  CD2   . TYR A 1 558 ? 151.354 177.662 166.187 1.00 74.58  ? 548 TYR A CD2   1 
ATOM   4558 C  CE1   . TYR A 1 558 ? 149.987 179.690 164.919 1.00 80.04  ? 548 TYR A CE1   1 
ATOM   4559 C  CE2   . TYR A 1 558 ? 150.020 177.504 165.887 1.00 78.77  ? 548 TYR A CE2   1 
ATOM   4560 C  CZ    . TYR A 1 558 ? 149.342 178.520 165.254 1.00 83.19  ? 548 TYR A CZ    1 
ATOM   4561 O  OH    . TYR A 1 558 ? 148.011 178.369 164.954 1.00 88.50  ? 548 TYR A OH    1 
ATOM   4562 N  N     . HIS A 1 559 ? 153.083 180.277 168.969 1.00 73.79  ? 549 HIS A N     1 
ATOM   4563 C  CA    . HIS A 1 559 ? 152.299 180.717 170.114 1.00 71.48  ? 549 HIS A CA    1 
ATOM   4564 C  C     . HIS A 1 559 ? 152.928 181.900 170.835 1.00 75.64  ? 549 HIS A C     1 
ATOM   4565 O  O     . HIS A 1 559 ? 152.362 182.372 171.826 1.00 79.55  ? 549 HIS A O     1 
ATOM   4566 C  CB    . HIS A 1 559 ? 152.093 179.556 171.085 1.00 72.28  ? 549 HIS A CB    1 
ATOM   4567 C  CG    . HIS A 1 559 ? 151.254 178.450 170.527 1.00 66.96  ? 549 HIS A CG    1 
ATOM   4568 N  ND1   . HIS A 1 559 ? 149.878 178.452 170.600 1.00 66.38  ? 549 HIS A ND1   1 
ATOM   4569 C  CD2   . HIS A 1 559 ? 151.593 177.313 169.878 1.00 65.70  ? 549 HIS A CD2   1 
ATOM   4570 C  CE1   . HIS A 1 559 ? 149.408 177.361 170.026 1.00 65.40  ? 549 HIS A CE1   1 
ATOM   4571 N  NE2   . HIS A 1 559 ? 150.428 176.652 169.579 1.00 62.25  ? 549 HIS A NE2   1 
ATOM   4572 N  N     . LYS A 1 560 ? 154.075 182.383 170.353 1.00 76.99  ? 550 LYS A N     1 
ATOM   4573 C  CA    . LYS A 1 560 ? 154.702 183.618 170.828 1.00 79.92  ? 550 LYS A CA    1 
ATOM   4574 C  C     . LYS A 1 560 ? 155.064 183.549 172.312 1.00 87.27  ? 550 LYS A C     1 
ATOM   4575 O  O     . LYS A 1 560 ? 154.928 184.528 173.047 1.00 89.95  ? 550 LYS A O     1 
ATOM   4576 C  CB    . LYS A 1 560 ? 153.818 184.838 170.545 1.00 76.25  ? 550 LYS A CB    1 
ATOM   4577 C  CG    . LYS A 1 560 ? 153.057 184.800 169.222 1.00 76.45  ? 550 LYS A CG    1 
ATOM   4578 C  CD    . LYS A 1 560 ? 153.975 184.612 168.025 1.00 77.46  ? 550 LYS A CD    1 
ATOM   4579 C  CE    . LYS A 1 560 ? 154.757 185.872 167.708 1.00 76.34  ? 550 LYS A CE    1 
ATOM   4580 N  NZ    . LYS A 1 560 ? 155.511 185.741 166.434 1.00 75.08  ? 550 LYS A NZ    1 
ATOM   4581 N  N     . LEU A 1 561 ? 155.533 182.387 172.758 1.00 88.27  ? 551 LEU A N     1 
ATOM   4582 C  CA    . LEU A 1 561 ? 156.141 182.265 174.086 1.00 90.59  ? 551 LEU A CA    1 
ATOM   4583 C  C     . LEU A 1 561 ? 157.652 182.449 174.024 1.00 93.29  ? 551 LEU A C     1 
ATOM   4584 O  O     . LEU A 1 561 ? 158.422 181.628 174.515 1.00 95.52  ? 551 LEU A O     1 
ATOM   4585 C  CB    . LEU A 1 561 ? 155.782 180.929 174.726 1.00 83.85  ? 551 LEU A CB    1 
ATOM   4586 C  CG    . LEU A 1 561 ? 154.408 180.773 175.379 1.00 84.46  ? 551 LEU A CG    1 
ATOM   4587 C  CD1   . LEU A 1 561 ? 153.286 180.709 174.363 1.00 81.80  ? 551 LEU A CD1   1 
ATOM   4588 C  CD2   . LEU A 1 561 ? 154.397 179.544 176.265 1.00 89.01  ? 551 LEU A CD2   1 
ATOM   4589 N  N     . GLU A 1 562 ? 158.086 183.544 173.408 1.00 97.30  ? 552 GLU A N     1 
ATOM   4590 C  CA    . GLU A 1 562 ? 159.493 183.916 173.382 1.00 100.23 ? 552 GLU A CA    1 
ATOM   4591 C  C     . GLU A 1 562 ? 159.589 185.401 173.682 1.00 105.29 ? 552 GLU A C     1 
ATOM   4592 O  O     . GLU A 1 562 ? 158.894 186.205 173.055 1.00 104.57 ? 552 GLU A O     1 
ATOM   4593 C  CB    . GLU A 1 562 ? 160.135 183.598 172.029 1.00 94.93  ? 552 GLU A CB    1 
ATOM   4594 C  CG    . GLU A 1 562 ? 161.513 184.202 171.846 1.00 96.60  ? 552 GLU A CG    1 
ATOM   4595 C  CD    . GLU A 1 562 ? 162.337 183.451 170.822 1.00 96.03  ? 552 GLU A CD    1 
ATOM   4596 O  OE1   . GLU A 1 562 ? 161.931 182.334 170.441 1.00 93.06  ? 552 GLU A OE1   1 
ATOM   4597 O  OE2   . GLU A 1 562 ? 163.388 183.977 170.397 1.00 98.20  ? 552 GLU A OE2   1 
ATOM   4598 N  N     . ASN A 1 563 ? 160.436 185.755 174.648 1.00 110.21 ? 553 ASN A N     1 
ATOM   4599 C  CA    . ASN A 1 563 ? 160.595 187.101 175.190 1.00 113.64 ? 553 ASN A CA    1 
ATOM   4600 C  C     . ASN A 1 563 ? 159.342 187.580 175.912 1.00 114.92 ? 553 ASN A C     1 
ATOM   4601 O  O     . ASN A 1 563 ? 159.307 188.727 176.371 1.00 117.46 ? 553 ASN A O     1 
ATOM   4602 C  CB    . ASN A 1 563 ? 160.988 188.125 174.116 1.00 112.49 ? 553 ASN A CB    1 
ATOM   4603 C  CG    . ASN A 1 563 ? 162.294 187.776 173.433 1.00 103.97 ? 553 ASN A CG    1 
ATOM   4604 O  OD1   . ASN A 1 563 ? 162.837 186.690 173.629 1.00 101.49 ? 553 ASN A OD1   1 
ATOM   4605 N  ND2   . ASN A 1 563 ? 162.803 188.694 172.623 1.00 100.64 ? 553 ASN A ND2   1 
ATOM   4606 N  N     . GLN A 1 564 ? 158.312 186.746 176.022 1.00 112.46 ? 554 GLN A N     1 
ATOM   4607 C  CA    . GLN A 1 564 ? 157.132 187.063 176.810 1.00 118.26 ? 554 GLN A CA    1 
ATOM   4608 C  C     . GLN A 1 564 ? 157.429 186.874 178.294 1.00 123.08 ? 554 GLN A C     1 
ATOM   4609 O  O     . GLN A 1 564 ? 158.227 186.016 178.683 1.00 122.09 ? 554 GLN A O     1 
ATOM   4610 C  CB    . GLN A 1 564 ? 155.960 186.176 176.378 1.00 115.61 ? 554 GLN A CB    1 
ATOM   4611 C  CG    . GLN A 1 564 ? 154.696 186.311 177.215 1.00 121.26 ? 554 GLN A CG    1 
ATOM   4612 C  CD    . GLN A 1 564 ? 153.889 187.546 176.866 1.00 117.65 ? 554 GLN A CD    1 
ATOM   4613 O  OE1   . GLN A 1 564 ? 154.072 188.143 175.805 1.00 113.28 ? 554 GLN A OE1   1 
ATOM   4614 N  NE2   . GLN A 1 564 ? 152.989 187.937 177.760 1.00 116.87 ? 554 GLN A NE2   1 
ATOM   4615 N  N     . ASN A 1 565 ? 156.793 187.699 179.124 1.00 122.02 ? 555 ASN A N     1 
ATOM   4616 C  CA    . ASN A 1 565 ? 157.005 187.617 180.563 1.00 122.41 ? 555 ASN A CA    1 
ATOM   4617 C  C     . ASN A 1 565 ? 156.506 186.284 181.108 1.00 127.59 ? 555 ASN A C     1 
ATOM   4618 O  O     . ASN A 1 565 ? 155.418 185.818 180.758 1.00 128.68 ? 555 ASN A O     1 
ATOM   4619 C  CB    . ASN A 1 565 ? 156.294 188.770 181.269 1.00 121.49 ? 555 ASN A CB    1 
ATOM   4620 C  CG    . ASN A 1 565 ? 156.668 188.873 182.733 1.00 123.71 ? 555 ASN A CG    1 
ATOM   4621 O  OD1   . ASN A 1 565 ? 157.619 188.240 183.188 1.00 122.20 ? 555 ASN A OD1   1 
ATOM   4622 N  ND2   . ASN A 1 565 ? 155.915 189.671 183.482 1.00 120.33 ? 555 ASN A ND2   1 
ATOM   4623 N  N     . VAL A 1 566 ? 157.314 185.667 181.974 1.00 128.28 ? 556 VAL A N     1 
ATOM   4624 C  CA    . VAL A 1 566 ? 156.946 184.370 182.532 1.00 127.42 ? 556 VAL A CA    1 
ATOM   4625 C  C     . VAL A 1 566 ? 155.786 184.501 183.512 1.00 127.94 ? 556 VAL A C     1 
ATOM   4626 O  O     . VAL A 1 566 ? 154.972 183.579 183.646 1.00 126.65 ? 556 VAL A O     1 
ATOM   4627 C  CB    . VAL A 1 566 ? 158.165 183.699 183.192 1.00 123.83 ? 556 VAL A CB    1 
ATOM   4628 C  CG1   . VAL A 1 566 ? 159.275 183.506 182.178 1.00 118.20 ? 556 VAL A CG1   1 
ATOM   4629 C  CG2   . VAL A 1 566 ? 158.655 184.517 184.373 1.00 123.47 ? 556 VAL A CG2   1 
ATOM   4630 N  N     . ASN A 1 567 ? 155.687 185.632 184.214 1.00 127.61 ? 557 ASN A N     1 
ATOM   4631 C  CA    . ASN A 1 567 ? 154.628 185.788 185.206 1.00 127.78 ? 557 ASN A CA    1 
ATOM   4632 C  C     . ASN A 1 567 ? 153.267 185.961 184.545 1.00 125.20 ? 557 ASN A C     1 
ATOM   4633 O  O     . ASN A 1 567 ? 152.274 185.378 184.995 1.00 120.21 ? 557 ASN A O     1 
ATOM   4634 C  CB    . ASN A 1 567 ? 154.941 186.969 186.124 1.00 126.54 ? 557 ASN A CB    1 
ATOM   4635 C  CG    . ASN A 1 567 ? 156.242 186.789 186.881 1.00 125.76 ? 557 ASN A CG    1 
ATOM   4636 O  OD1   . ASN A 1 567 ? 156.783 185.686 186.955 1.00 117.91 ? 557 ASN A OD1   1 
ATOM   4637 N  ND2   . ASN A 1 567 ? 156.753 187.876 187.447 1.00 127.26 ? 557 ASN A ND2   1 
ATOM   4638 N  N     . ASP A 1 568 ? 153.199 186.757 183.481 1.00 126.60 ? 558 ASP A N     1 
ATOM   4639 C  CA    . ASP A 1 568 ? 151.961 186.994 182.746 1.00 125.10 ? 558 ASP A CA    1 
ATOM   4640 C  C     . ASP A 1 568 ? 152.166 186.529 181.311 1.00 121.80 ? 558 ASP A C     1 
ATOM   4641 O  O     . ASP A 1 568 ? 152.899 187.164 180.546 1.00 122.64 ? 558 ASP A O     1 
ATOM   4642 C  CB    . ASP A 1 568 ? 151.564 188.469 182.800 1.00 121.14 ? 558 ASP A CB    1 
ATOM   4643 C  CG    . ASP A 1 568 ? 150.915 188.847 184.117 1.00 117.55 ? 558 ASP A CG    1 
ATOM   4644 O  OD1   . ASP A 1 568 ? 150.470 187.934 184.844 1.00 118.04 ? 558 ASP A OD1   1 
ATOM   4645 O  OD2   . ASP A 1 568 ? 150.853 190.054 184.429 1.00 112.12 ? 558 ASP A OD2   1 
ATOM   4646 N  N     . ILE A 1 569 ? 151.519 185.426 180.948 1.00 118.35 ? 559 ILE A N     1 
ATOM   4647 C  CA    . ILE A 1 569 ? 151.681 184.806 179.639 1.00 118.13 ? 559 ILE A CA    1 
ATOM   4648 C  C     . ILE A 1 569 ? 150.447 185.134 178.813 1.00 117.95 ? 559 ILE A C     1 
ATOM   4649 O  O     . ILE A 1 569 ? 149.335 184.701 179.142 1.00 113.49 ? 559 ILE A O     1 
ATOM   4650 C  CB    . ILE A 1 569 ? 151.889 183.290 179.748 1.00 116.66 ? 559 ILE A CB    1 
ATOM   4651 C  CG1   . ILE A 1 569 ? 153.063 182.980 180.677 1.00 117.11 ? 559 ILE A CG1   1 
ATOM   4652 C  CG2   . ILE A 1 569 ? 152.116 182.684 178.373 1.00 114.34 ? 559 ILE A CG2   1 
ATOM   4653 C  CD1   . ILE A 1 569 ? 153.431 181.514 180.727 1.00 112.31 ? 559 ILE A CD1   1 
ATOM   4654 N  N     . LYS A 1 570 ? 150.639 185.894 177.737 1.00 119.42 ? 560 LYS A N     1 
ATOM   4655 C  CA    . LYS A 1 570 ? 149.555 186.235 176.819 1.00 117.12 ? 560 LYS A CA    1 
ATOM   4656 C  C     . LYS A 1 570 ? 149.523 185.183 175.718 1.00 111.73 ? 560 LYS A C     1 
ATOM   4657 O  O     . LYS A 1 570 ? 150.258 185.272 174.732 1.00 111.43 ? 560 LYS A O     1 
ATOM   4658 C  CB    . LYS A 1 570 ? 149.738 187.640 176.258 1.00 114.13 ? 560 LYS A CB    1 
ATOM   4659 C  CG    . LYS A 1 570 ? 149.743 188.726 177.321 1.00 114.47 ? 560 LYS A CG    1 
ATOM   4660 C  CD    . LYS A 1 570 ? 148.665 188.477 178.364 1.00 118.19 ? 560 LYS A CD    1 
ATOM   4661 C  CE    . LYS A 1 570 ? 149.049 189.063 179.710 1.00 116.78 ? 560 LYS A CE    1 
ATOM   4662 N  NZ    . LYS A 1 570 ? 148.069 188.705 180.771 1.00 112.64 ? 560 LYS A NZ    1 
ATOM   4663 N  N     . ALA A 1 571 ? 148.668 184.179 175.894 1.00 107.43 ? 561 ALA A N     1 
ATOM   4664 C  CA    . ALA A 1 571 ? 148.555 183.082 174.948 1.00 104.80 ? 561 ALA A CA    1 
ATOM   4665 C  C     . ALA A 1 571 ? 147.139 182.532 175.010 1.00 105.61 ? 561 ALA A C     1 
ATOM   4666 O  O     . ALA A 1 571 ? 146.368 182.846 175.920 1.00 104.32 ? 561 ALA A O     1 
ATOM   4667 C  CB    . ALA A 1 571 ? 149.578 181.983 175.239 1.00 101.82 ? 561 ALA A CB    1 
ATOM   4668 N  N     . SER A 1 572 ? 146.801 181.708 174.023 1.00 105.79 ? 562 SER A N     1 
ATOM   4669 C  CA    . SER A 1 572 ? 145.495 181.067 174.013 1.00 105.65 ? 562 SER A CA    1 
ATOM   4670 C  C     . SER A 1 572 ? 145.344 180.173 175.238 1.00 105.80 ? 562 SER A C     1 
ATOM   4671 O  O     . SER A 1 572 ? 146.319 179.623 175.757 1.00 103.58 ? 562 SER A O     1 
ATOM   4672 C  CB    . SER A 1 572 ? 145.306 180.260 172.729 1.00 98.73  ? 562 SER A CB    1 
ATOM   4673 O  OG    . SER A 1 572 ? 146.352 179.321 172.557 1.00 97.69  ? 562 SER A OG    1 
ATOM   4674 N  N     . ASP A 1 573 ? 144.100 180.044 175.708 1.00 104.90 ? 563 ASP A N     1 
ATOM   4675 C  CA    . ASP A 1 573 ? 143.850 179.405 176.997 1.00 102.89 ? 563 ASP A CA    1 
ATOM   4676 C  C     . ASP A 1 573 ? 144.313 177.954 177.017 1.00 99.81  ? 563 ASP A C     1 
ATOM   4677 O  O     . ASP A 1 573 ? 144.680 177.439 178.079 1.00 98.56  ? 563 ASP A O     1 
ATOM   4678 C  CB    . ASP A 1 573 ? 142.365 179.500 177.347 1.00 103.00 ? 563 ASP A CB    1 
ATOM   4679 C  CG    . ASP A 1 573 ? 142.131 179.822 178.812 1.00 103.14 ? 563 ASP A CG    1 
ATOM   4680 O  OD1   . ASP A 1 573 ? 143.029 179.547 179.634 1.00 100.65 ? 563 ASP A OD1   1 
ATOM   4681 O  OD2   . ASP A 1 573 ? 141.051 180.358 179.142 1.00 100.67 ? 563 ASP A OD2   1 
ATOM   4682 N  N     . LYS A 1 574 ? 144.309 177.283 175.863 1.00 97.75  ? 564 LYS A N     1 
ATOM   4683 C  CA    . LYS A 1 574 ? 144.818 175.916 175.800 1.00 98.50  ? 564 LYS A CA    1 
ATOM   4684 C  C     . LYS A 1 574 ? 146.290 175.864 176.189 1.00 101.03 ? 564 LYS A C     1 
ATOM   4685 O  O     . LYS A 1 574 ? 146.720 174.966 176.926 1.00 98.36  ? 564 LYS A O     1 
ATOM   4686 C  CB    . LYS A 1 574 ? 144.611 175.347 174.395 1.00 97.27  ? 564 LYS A CB    1 
ATOM   4687 C  CG    . LYS A 1 574 ? 144.704 173.831 174.304 1.00 98.23  ? 564 LYS A CG    1 
ATOM   4688 C  CD    . LYS A 1 574 ? 143.513 173.161 174.964 1.00 97.06  ? 564 LYS A CD    1 
ATOM   4689 C  CE    . LYS A 1 574 ? 143.453 171.684 174.618 1.00 93.32  ? 564 LYS A CE    1 
ATOM   4690 N  NZ    . LYS A 1 574 ? 142.205 171.044 175.121 1.00 84.56  ? 564 LYS A NZ    1 
ATOM   4691 N  N     . VAL A 1 575 ? 147.075 176.829 175.709 1.00 100.01 ? 565 VAL A N     1 
ATOM   4692 C  CA    . VAL A 1 575 ? 148.478 176.909 176.096 1.00 93.69  ? 565 VAL A CA    1 
ATOM   4693 C  C     . VAL A 1 575 ? 148.601 177.152 177.593 1.00 92.65  ? 565 VAL A C     1 
ATOM   4694 O  O     . VAL A 1 575 ? 149.500 176.616 178.248 1.00 90.96  ? 565 VAL A O     1 
ATOM   4695 C  CB    . VAL A 1 575 ? 149.195 178.001 175.284 1.00 93.94  ? 565 VAL A CB    1 
ATOM   4696 C  CG1   . VAL A 1 575 ? 150.687 177.955 175.543 1.00 86.88  ? 565 VAL A CG1   1 
ATOM   4697 C  CG2   . VAL A 1 575 ? 148.906 177.827 173.809 1.00 92.62  ? 565 VAL A CG2   1 
ATOM   4698 N  N     . LYS A 1 576 ? 147.707 177.966 178.159 1.00 96.01  ? 566 LYS A N     1 
ATOM   4699 C  CA    . LYS A 1 576 ? 147.741 178.200 179.599 1.00 97.83  ? 566 LYS A CA    1 
ATOM   4700 C  C     . LYS A 1 576 ? 147.493 176.911 180.369 1.00 95.61  ? 566 LYS A C     1 
ATOM   4701 O  O     . LYS A 1 576 ? 148.194 176.616 181.345 1.00 93.48  ? 566 LYS A O     1 
ATOM   4702 C  CB    . LYS A 1 576 ? 146.714 179.260 179.990 1.00 95.35  ? 566 LYS A CB    1 
ATOM   4703 C  CG    . LYS A 1 576 ? 146.668 179.542 181.483 1.00 96.17  ? 566 LYS A CG    1 
ATOM   4704 C  CD    . LYS A 1 576 ? 145.834 180.772 181.789 1.00 96.40  ? 566 LYS A CD    1 
ATOM   4705 C  CE    . LYS A 1 576 ? 145.699 180.988 183.288 1.00 97.63  ? 566 LYS A CE    1 
ATOM   4706 N  NZ    . LYS A 1 576 ? 147.021 181.040 183.968 1.00 104.53 ? 566 LYS A NZ    1 
ATOM   4707 N  N     . GLU A 1 577 ? 146.504 176.125 179.939 1.00 95.54  ? 567 GLU A N     1 
ATOM   4708 C  CA    . GLU A 1 577 ? 146.242 174.852 180.599 1.00 95.79  ? 567 GLU A CA    1 
ATOM   4709 C  C     . GLU A 1 577 ? 147.437 173.919 180.476 1.00 95.16  ? 567 GLU A C     1 
ATOM   4710 O  O     . GLU A 1 577 ? 147.770 173.198 181.423 1.00 95.19  ? 567 GLU A O     1 
ATOM   4711 C  CB    . GLU A 1 577 ? 144.989 174.196 180.018 1.00 95.55  ? 567 GLU A CB    1 
ATOM   4712 C  CG    . GLU A 1 577 ? 143.780 175.112 179.917 1.00 100.15 ? 567 GLU A CG    1 
ATOM   4713 C  CD    . GLU A 1 577 ? 143.242 175.540 181.271 1.00 102.63 ? 567 GLU A CD    1 
ATOM   4714 O  OE1   . GLU A 1 577 ? 143.559 174.878 182.281 1.00 103.84 ? 567 GLU A OE1   1 
ATOM   4715 O  OE2   . GLU A 1 577 ? 142.501 176.544 181.323 1.00 99.93  ? 567 GLU A OE2   1 
ATOM   4716 N  N     . TYR A 1 578 ? 148.091 173.914 179.313 1.00 92.97  ? 568 TYR A N     1 
ATOM   4717 C  CA    . TYR A 1 578 ? 149.266 173.064 179.136 1.00 89.52  ? 568 TYR A CA    1 
ATOM   4718 C  C     . TYR A 1 578 ? 150.418 173.500 180.037 1.00 87.40  ? 568 TYR A C     1 
ATOM   4719 O  O     . TYR A 1 578 ? 151.118 172.655 180.605 1.00 85.85  ? 568 TYR A O     1 
ATOM   4720 C  CB    . TYR A 1 578 ? 149.693 173.058 177.671 1.00 87.59  ? 568 TYR A CB    1 
ATOM   4721 C  CG    . TYR A 1 578 ? 148.834 172.165 176.810 1.00 88.03  ? 568 TYR A CG    1 
ATOM   4722 C  CD1   . TYR A 1 578 ? 148.184 171.067 177.357 1.00 87.53  ? 568 TYR A CD1   1 
ATOM   4723 C  CD2   . TYR A 1 578 ? 148.673 172.414 175.454 1.00 83.74  ? 568 TYR A CD2   1 
ATOM   4724 C  CE1   . TYR A 1 578 ? 147.394 170.245 176.580 1.00 87.98  ? 568 TYR A CE1   1 
ATOM   4725 C  CE2   . TYR A 1 578 ? 147.887 171.595 174.669 1.00 82.29  ? 568 TYR A CE2   1 
ATOM   4726 C  CZ    . TYR A 1 578 ? 147.252 170.511 175.237 1.00 87.34  ? 568 TYR A CZ    1 
ATOM   4727 O  OH    . TYR A 1 578 ? 146.466 169.690 174.465 1.00 88.64  ? 568 TYR A OH    1 
ATOM   4728 N  N     . ILE A 1 579 ? 150.634 174.810 180.175 1.00 92.87  ? 569 ILE A N     1 
ATOM   4729 C  CA    . ILE A 1 579 ? 151.705 175.311 181.035 1.00 90.30  ? 569 ILE A CA    1 
ATOM   4730 C  C     . ILE A 1 579 ? 151.407 175.013 182.499 1.00 87.72  ? 569 ILE A C     1 
ATOM   4731 O  O     . ILE A 1 579 ? 152.322 174.749 183.289 1.00 81.62  ? 569 ILE A O     1 
ATOM   4732 C  CB    . ILE A 1 579 ? 151.928 176.816 180.799 1.00 91.74  ? 569 ILE A CB    1 
ATOM   4733 C  CG1   . ILE A 1 579 ? 152.371 177.075 179.362 1.00 95.76  ? 569 ILE A CG1   1 
ATOM   4734 C  CG2   . ILE A 1 579 ? 152.950 177.371 181.772 1.00 83.29  ? 569 ILE A CG2   1 
ATOM   4735 C  CD1   . ILE A 1 579 ? 152.074 178.470 178.895 1.00 101.02 ? 569 ILE A CD1   1 
ATOM   4736 N  N     . GLU A 1 580 ? 150.132 175.067 182.893 1.00 91.62  ? 570 GLU A N     1 
ATOM   4737 C  CA    . GLU A 1 580 ? 149.779 174.720 184.267 1.00 89.87  ? 570 GLU A CA    1 
ATOM   4738 C  C     . GLU A 1 580 ? 150.119 173.265 184.568 1.00 87.70  ? 570 GLU A C     1 
ATOM   4739 O  O     . GLU A 1 580 ? 150.579 172.941 185.669 1.00 86.17  ? 570 GLU A O     1 
ATOM   4740 C  CB    . GLU A 1 580 ? 148.299 175.004 184.520 1.00 92.77  ? 570 GLU A CB    1 
ATOM   4741 C  CG    . GLU A 1 580 ? 147.967 176.486 184.557 1.00 98.79  ? 570 GLU A CG    1 
ATOM   4742 C  CD    . GLU A 1 580 ? 146.485 176.763 184.411 1.00 104.95 ? 570 GLU A CD    1 
ATOM   4743 O  OE1   . GLU A 1 580 ? 145.818 176.046 183.639 1.00 103.58 ? 570 GLU A OE1   1 
ATOM   4744 O  OE2   . GLU A 1 580 ? 145.986 177.699 185.071 1.00 104.53 ? 570 GLU A OE2   1 
ATOM   4745 N  N     . ASN A 1 581 ? 149.896 172.374 183.607 1.00 85.21  ? 571 ASN A N     1 
ATOM   4746 C  CA    . ASN A 1 581 ? 150.484 171.049 183.680 1.00 82.77  ? 571 ASN A CA    1 
ATOM   4747 C  C     . ASN A 1 581 ? 151.995 171.143 183.490 1.00 85.62  ? 571 ASN A C     1 
ATOM   4748 O  O     . ASN A 1 581 ? 152.510 172.057 182.843 1.00 88.43  ? 571 ASN A O     1 
ATOM   4749 C  CB    . ASN A 1 581 ? 149.876 170.133 182.619 1.00 85.20  ? 571 ASN A CB    1 
ATOM   4750 C  CG    . ASN A 1 581 ? 148.407 169.858 182.858 1.00 91.01  ? 571 ASN A CG    1 
ATOM   4751 O  OD1   . ASN A 1 581 ? 147.916 169.977 183.980 1.00 92.72  ? 571 ASN A OD1   1 
ATOM   4752 N  ND2   . ASN A 1 581 ? 147.695 169.489 181.800 1.00 88.67  ? 571 ASN A ND2   1 
ATOM   4753 N  N     . GLY A 1 582 ? 152.714 170.182 184.058 1.00 80.54  ? 572 GLY A N     1 
ATOM   4754 C  CA    . GLY A 1 582 ? 154.163 170.245 184.024 1.00 78.04  ? 572 GLY A CA    1 
ATOM   4755 C  C     . GLY A 1 582 ? 154.780 169.811 182.710 1.00 78.36  ? 572 GLY A C     1 
ATOM   4756 O  O     . GLY A 1 582 ? 155.783 169.092 182.701 1.00 76.86  ? 572 GLY A O     1 
ATOM   4757 N  N     . TYR A 1 583 ? 154.204 170.255 181.590 1.00 79.87  ? 573 TYR A N     1 
ATOM   4758 C  CA    . TYR A 1 583 ? 154.632 169.757 180.287 1.00 74.88  ? 573 TYR A CA    1 
ATOM   4759 C  C     . TYR A 1 583 ? 155.885 170.464 179.787 1.00 72.98  ? 573 TYR A C     1 
ATOM   4760 O  O     . TYR A 1 583 ? 156.848 169.809 179.376 1.00 73.36  ? 573 TYR A O     1 
ATOM   4761 C  CB    . TYR A 1 583 ? 153.495 169.895 179.273 1.00 75.38  ? 573 TYR A CB    1 
ATOM   4762 C  CG    . TYR A 1 583 ? 152.295 169.034 179.595 1.00 78.05  ? 573 TYR A CG    1 
ATOM   4763 C  CD1   . TYR A 1 583 ? 152.441 167.843 180.294 1.00 71.80  ? 573 TYR A CD1   1 
ATOM   4764 C  CD2   . TYR A 1 583 ? 151.019 169.405 179.196 1.00 78.65  ? 573 TYR A CD2   1 
ATOM   4765 C  CE1   . TYR A 1 583 ? 151.355 167.052 180.590 1.00 67.34  ? 573 TYR A CE1   1 
ATOM   4766 C  CE2   . TYR A 1 583 ? 149.925 168.616 179.492 1.00 75.31  ? 573 TYR A CE2   1 
ATOM   4767 C  CZ    . TYR A 1 583 ? 150.102 167.442 180.188 1.00 70.45  ? 573 TYR A CZ    1 
ATOM   4768 O  OH    . TYR A 1 583 ? 149.020 166.650 180.484 1.00 71.30  ? 573 TYR A OH    1 
ATOM   4769 N  N     . TYR A 1 584 ? 155.898 171.793 179.805 1.00 73.87  ? 574 TYR A N     1 
ATOM   4770 C  CA    . TYR A 1 584 ? 157.009 172.561 179.257 1.00 74.02  ? 574 TYR A CA    1 
ATOM   4771 C  C     . TYR A 1 584 ? 157.869 173.138 180.371 1.00 78.73  ? 574 TYR A C     1 
ATOM   4772 O  O     . TYR A 1 584 ? 157.353 173.739 181.318 1.00 76.97  ? 574 TYR A O     1 
ATOM   4773 C  CB    . TYR A 1 584 ? 156.513 173.691 178.356 1.00 68.64  ? 574 TYR A CB    1 
ATOM   4774 C  CG    . TYR A 1 584 ? 155.711 173.231 177.165 1.00 69.53  ? 574 TYR A CG    1 
ATOM   4775 C  CD1   . TYR A 1 584 ? 156.336 172.915 175.970 1.00 66.87  ? 574 TYR A CD1   1 
ATOM   4776 C  CD2   . TYR A 1 584 ? 154.328 173.135 177.228 1.00 66.19  ? 574 TYR A CD2   1 
ATOM   4777 C  CE1   . TYR A 1 584 ? 155.610 172.502 174.877 1.00 64.32  ? 574 TYR A CE1   1 
ATOM   4778 C  CE2   . TYR A 1 584 ? 153.593 172.724 176.139 1.00 62.33  ? 574 TYR A CE2   1 
ATOM   4779 C  CZ    . TYR A 1 584 ? 154.241 172.409 174.966 1.00 63.20  ? 574 TYR A CZ    1 
ATOM   4780 O  OH    . TYR A 1 584 ? 153.518 171.999 173.873 1.00 64.91  ? 574 TYR A OH    1 
ATOM   4781 N  N     . GLU A 1 585 ? 159.179 172.952 180.249 1.00 81.10  ? 575 GLU A N     1 
ATOM   4782 C  CA    . GLU A 1 585 ? 160.157 173.610 181.103 1.00 83.25  ? 575 GLU A CA    1 
ATOM   4783 C  C     . GLU A 1 585 ? 160.741 174.784 180.327 1.00 88.94  ? 575 GLU A C     1 
ATOM   4784 O  O     . GLU A 1 585 ? 161.250 174.604 179.217 1.00 90.61  ? 575 GLU A O     1 
ATOM   4785 C  CB    . GLU A 1 585 ? 161.257 172.636 181.523 1.00 79.90  ? 575 GLU A CB    1 
ATOM   4786 C  CG    . GLU A 1 585 ? 162.396 173.276 182.297 1.00 86.76  ? 575 GLU A CG    1 
ATOM   4787 C  CD    . GLU A 1 585 ? 163.668 172.456 182.238 1.00 95.23  ? 575 GLU A CD    1 
ATOM   4788 O  OE1   . GLU A 1 585 ? 163.799 171.626 181.314 1.00 91.75  ? 575 GLU A OE1   1 
ATOM   4789 O  OE2   . GLU A 1 585 ? 164.538 172.639 183.116 1.00 94.01  ? 575 GLU A OE2   1 
ATOM   4790 N  N     . LEU A 1 586 ? 160.663 175.977 180.904 1.00 87.72  ? 576 LEU A N     1 
ATOM   4791 C  CA    . LEU A 1 586 ? 161.092 177.194 180.232 1.00 89.77  ? 576 LEU A CA    1 
ATOM   4792 C  C     . LEU A 1 586 ? 162.455 177.629 180.753 1.00 93.81  ? 576 LEU A C     1 
ATOM   4793 O  O     . LEU A 1 586 ? 162.728 177.551 181.954 1.00 93.80  ? 576 LEU A O     1 
ATOM   4794 C  CB    . LEU A 1 586 ? 160.072 178.316 180.437 1.00 88.64  ? 576 LEU A CB    1 
ATOM   4795 C  CG    . LEU A 1 586 ? 158.667 178.099 179.869 1.00 84.04  ? 576 LEU A CG    1 
ATOM   4796 C  CD1   . LEU A 1 586 ? 157.666 178.986 180.581 1.00 84.71  ? 576 LEU A CD1   1 
ATOM   4797 C  CD2   . LEU A 1 586 ? 158.630 178.352 178.379 1.00 79.09  ? 576 LEU A CD2   1 
ATOM   4798 N  N     . ILE A 1 587 ? 163.310 178.087 179.843 1.00 97.61  ? 577 ILE A N     1 
ATOM   4799 C  CA    . ILE A 1 587 ? 164.647 178.558 180.182 1.00 100.14 ? 577 ILE A CA    1 
ATOM   4800 C  C     . ILE A 1 587 ? 164.624 180.080 180.204 1.00 104.94 ? 577 ILE A C     1 
ATOM   4801 O  O     . ILE A 1 587 ? 164.282 180.719 179.202 1.00 104.98 ? 577 ILE A O     1 
ATOM   4802 C  CB    . ILE A 1 587 ? 165.695 178.034 179.190 1.00 98.69  ? 577 ILE A CB    1 
ATOM   4803 C  CG1   . ILE A 1 587 ? 165.524 176.529 178.988 1.00 95.05  ? 577 ILE A CG1   1 
ATOM   4804 C  CG2   . ILE A 1 587 ? 167.098 178.353 179.683 1.00 98.77  ? 577 ILE A CG2   1 
ATOM   4805 C  CD1   . ILE A 1 587 ? 166.620 175.895 178.160 1.00 88.79  ? 577 ILE A CD1   1 
ATOM   4806 N  N     . THR A 1 588 ? 164.995 180.662 181.340 1.00 107.76 ? 578 THR A N     1 
ATOM   4807 C  CA    . THR A 1 588 ? 164.905 182.100 181.530 1.00 112.57 ? 578 THR A CA    1 
ATOM   4808 C  C     . THR A 1 588 ? 166.223 182.788 181.178 1.00 112.54 ? 578 THR A C     1 
ATOM   4809 O  O     . THR A 1 588 ? 167.236 182.150 180.885 1.00 108.17 ? 578 THR A O     1 
ATOM   4810 C  CB    . THR A 1 588 ? 164.507 182.427 182.969 1.00 111.01 ? 578 THR A CB    1 
ATOM   4811 O  OG1   . THR A 1 588 ? 165.632 182.232 183.834 1.00 105.36 ? 578 THR A OG1   1 
ATOM   4812 C  CG2   . THR A 1 588 ? 163.365 181.531 183.419 1.00 103.46 ? 578 THR A CG2   1 
ATOM   4813 N  N     . ASN A 1 589 ? 166.193 184.119 181.217 1.00 116.69 ? 579 ASN A N     1 
ATOM   4814 C  CA    . ASN A 1 589 ? 167.352 184.939 180.888 1.00 116.08 ? 579 ASN A CA    1 
ATOM   4815 C  C     . ASN A 1 589 ? 167.621 185.957 181.989 1.00 116.17 ? 579 ASN A C     1 
ATOM   4816 O  O     . ASN A 1 589 ? 167.074 185.847 183.092 1.00 114.37 ? 579 ASN A O     1 
ATOM   4817 C  CB    . ASN A 1 589 ? 167.152 185.642 179.542 1.00 115.51 ? 579 ASN A CB    1 
ATOM   4818 C  CG    . ASN A 1 589 ? 166.011 186.648 179.563 1.00 114.11 ? 579 ASN A CG    1 
ATOM   4819 O  OD1   . ASN A 1 589 ? 165.242 186.722 180.520 1.00 113.93 ? 579 ASN A OD1   1 
ATOM   4820 N  ND2   . ASN A 1 589 ? 165.900 187.429 178.496 1.00 111.42 ? 579 ASN A ND2   1 
ATOM   4821 N  N     . GLU A 1 590 ? 168.479 186.940 181.701 1.00 118.30 ? 580 GLU A N     1 
ATOM   4822 C  CA    . GLU A 1 590 ? 168.741 188.010 182.660 1.00 119.47 ? 580 GLU A CA    1 
ATOM   4823 C  C     . GLU A 1 590 ? 167.459 188.711 183.089 1.00 116.86 ? 580 GLU A C     1 
ATOM   4824 O  O     . GLU A 1 590 ? 167.353 189.167 184.233 1.00 111.12 ? 580 GLU A O     1 
ATOM   4825 C  CB    . GLU A 1 590 ? 169.716 189.021 182.057 1.00 119.29 ? 580 GLU A CB    1 
ATOM   4826 C  CG    . GLU A 1 590 ? 171.062 188.435 181.665 1.00 117.03 ? 580 GLU A CG    1 
ATOM   4827 C  CD    . GLU A 1 590 ? 172.064 189.499 181.264 1.00 113.58 ? 580 GLU A CD    1 
ATOM   4828 O  OE1   . GLU A 1 590 ? 171.726 190.699 181.349 1.00 114.17 ? 580 GLU A OE1   1 
ATOM   4829 O  OE2   . GLU A 1 590 ? 173.190 189.136 180.863 1.00 110.23 ? 580 GLU A OE2   1 
ATOM   4830 N  N     . ASN A 1 591 ? 166.477 188.800 182.195 1.00 117.42 ? 581 ASN A N     1 
ATOM   4831 C  CA    . ASN A 1 591 ? 165.201 189.440 182.482 1.00 116.15 ? 581 ASN A CA    1 
ATOM   4832 C  C     . ASN A 1 591 ? 164.152 188.466 183.001 1.00 115.97 ? 581 ASN A C     1 
ATOM   4833 O  O     . ASN A 1 591 ? 162.992 188.857 183.164 1.00 114.33 ? 581 ASN A O     1 
ATOM   4834 C  CB    . ASN A 1 591 ? 164.674 190.144 181.230 1.00 115.95 ? 581 ASN A CB    1 
ATOM   4835 C  CG    . ASN A 1 591 ? 165.651 191.159 180.677 1.00 110.43 ? 581 ASN A CG    1 
ATOM   4836 O  OD1   . ASN A 1 591 ? 166.704 191.408 181.264 1.00 111.46 ? 581 ASN A OD1   1 
ATOM   4837 N  ND2   . ASN A 1 591 ? 165.307 191.752 179.540 1.00 104.04 ? 581 ASN A ND2   1 
ATOM   4838 N  N     . ASN A 1 592 ? 164.532 187.212 183.257 1.00 116.01 ? 582 ASN A N     1 
ATOM   4839 C  CA    . ASN A 1 592 ? 163.601 186.175 183.709 1.00 114.91 ? 582 ASN A CA    1 
ATOM   4840 C  C     . ASN A 1 592 ? 162.444 186.001 182.729 1.00 115.89 ? 582 ASN A C     1 
ATOM   4841 O  O     . ASN A 1 592 ? 161.292 185.818 183.125 1.00 116.41 ? 582 ASN A O     1 
ATOM   4842 C  CB    . ASN A 1 592 ? 163.078 186.462 185.119 1.00 114.29 ? 582 ASN A CB    1 
ATOM   4843 C  CG    . ASN A 1 592 ? 164.133 186.253 186.187 1.00 114.81 ? 582 ASN A CG    1 
ATOM   4844 O  OD1   . ASN A 1 592 ? 165.323 186.160 185.891 1.00 113.13 ? 582 ASN A OD1   1 
ATOM   4845 N  ND2   . ASN A 1 592 ? 163.698 186.173 187.439 1.00 113.64 ? 582 ASN A ND2   1 
ATOM   4846 N  N     . GLU A 1 593 ? 162.751 186.069 181.440 1.00 116.17 ? 583 GLU A N     1 
ATOM   4847 C  CA    . GLU A 1 593 ? 161.797 185.789 180.379 1.00 113.46 ? 583 GLU A CA    1 
ATOM   4848 C  C     . GLU A 1 593 ? 162.317 184.638 179.529 1.00 112.72 ? 583 GLU A C     1 
ATOM   4849 O  O     . GLU A 1 593 ? 163.463 184.204 179.659 1.00 111.91 ? 583 GLU A O     1 
ATOM   4850 C  CB    . GLU A 1 593 ? 161.539 187.029 179.515 1.00 113.28 ? 583 GLU A CB    1 
ATOM   4851 C  CG    . GLU A 1 593 ? 160.615 188.047 180.158 1.00 118.96 ? 583 GLU A CG    1 
ATOM   4852 C  CD    . GLU A 1 593 ? 160.421 189.279 179.298 1.00 122.84 ? 583 GLU A CD    1 
ATOM   4853 O  OE1   . GLU A 1 593 ? 161.224 189.483 178.363 1.00 121.54 ? 583 GLU A OE1   1 
ATOM   4854 O  OE2   . GLU A 1 593 ? 159.467 190.042 179.555 1.00 121.47 ? 583 GLU A OE2   1 
ATOM   4855 N  N     . ILE A 1 594 ? 161.460 184.152 178.642 1.00 113.62 ? 584 ILE A N     1 
ATOM   4856 C  CA    . ILE A 1 594 ? 161.727 182.910 177.928 1.00 110.20 ? 584 ILE A CA    1 
ATOM   4857 C  C     . ILE A 1 594 ? 162.590 183.187 176.705 1.00 106.82 ? 584 ILE A C     1 
ATOM   4858 O  O     . ILE A 1 594 ? 162.240 184.013 175.854 1.00 106.41 ? 584 ILE A O     1 
ATOM   4859 C  CB    . ILE A 1 594 ? 160.412 182.223 177.536 1.00 105.30 ? 584 ILE A CB    1 
ATOM   4860 C  CG1   . ILE A 1 594 ? 159.510 182.080 178.763 1.00 104.64 ? 584 ILE A CG1   1 
ATOM   4861 C  CG2   . ILE A 1 594 ? 160.692 180.875 176.893 1.00 100.22 ? 584 ILE A CG2   1 
ATOM   4862 C  CD1   . ILE A 1 594 ? 158.031 182.104 178.450 1.00 99.03  ? 584 ILE A CD1   1 
ATOM   4863 N  N     . VAL A 1 595 ? 163.722 182.493 176.616 1.00 106.83 ? 585 VAL A N     1 
ATOM   4864 C  CA    . VAL A 1 595 ? 164.514 182.459 175.395 1.00 107.66 ? 585 VAL A CA    1 
ATOM   4865 C  C     . VAL A 1 595 ? 164.514 181.080 174.747 1.00 102.66 ? 585 VAL A C     1 
ATOM   4866 O  O     . VAL A 1 595 ? 164.864 180.975 173.561 1.00 99.69  ? 585 VAL A O     1 
ATOM   4867 C  CB    . VAL A 1 595 ? 165.963 182.926 175.644 1.00 108.67 ? 585 VAL A CB    1 
ATOM   4868 C  CG1   . VAL A 1 595 ? 165.978 184.324 176.247 1.00 109.96 ? 585 VAL A CG1   1 
ATOM   4869 C  CG2   . VAL A 1 595 ? 166.698 181.936 176.532 1.00 104.30 ? 585 VAL A CG2   1 
ATOM   4870 N  N     . ASP A 1 596 ? 164.141 180.030 175.476 1.00 100.10 ? 586 ASP A N     1 
ATOM   4871 C  CA    . ASP A 1 596 ? 164.018 178.689 174.920 1.00 96.19  ? 586 ASP A CA    1 
ATOM   4872 C  C     . ASP A 1 596 ? 163.186 177.847 175.874 1.00 93.42  ? 586 ASP A C     1 
ATOM   4873 O  O     . ASP A 1 596 ? 162.975 178.215 177.031 1.00 95.64  ? 586 ASP A O     1 
ATOM   4874 C  CB    . ASP A 1 596 ? 165.386 178.043 174.681 1.00 98.90  ? 586 ASP A CB    1 
ATOM   4875 C  CG    . ASP A 1 596 ? 165.296 176.798 173.825 1.00 100.07 ? 586 ASP A CG    1 
ATOM   4876 O  OD1   . ASP A 1 596 ? 164.242 176.598 173.187 1.00 94.01  ? 586 ASP A OD1   1 
ATOM   4877 O  OD2   . ASP A 1 596 ? 166.274 176.022 173.789 1.00 103.08 ? 586 ASP A OD2   1 
ATOM   4878 N  N     . ALA A 1 597 ? 162.719 176.706 175.371 1.00 86.72  ? 587 ALA A N     1 
ATOM   4879 C  CA    . ALA A 1 597 ? 161.885 175.809 176.155 1.00 84.03  ? 587 ALA A CA    1 
ATOM   4880 C  C     . ALA A 1 597 ? 162.180 174.375 175.747 1.00 80.32  ? 587 ALA A C     1 
ATOM   4881 O  O     . ALA A 1 597 ? 162.769 174.117 174.695 1.00 80.38  ? 587 ALA A O     1 
ATOM   4882 C  CB    . ALA A 1 597 ? 160.398 176.122 175.976 1.00 82.61  ? 587 ALA A CB    1 
ATOM   4883 N  N     . LYS A 1 598 ? 161.772 173.439 176.601 1.00 77.21  ? 588 LYS A N     1 
ATOM   4884 C  CA    . LYS A 1 598 ? 161.957 172.021 176.339 1.00 72.92  ? 588 LYS A CA    1 
ATOM   4885 C  C     . LYS A 1 598 ? 160.751 171.257 176.863 1.00 70.54  ? 588 LYS A C     1 
ATOM   4886 O  O     . LYS A 1 598 ? 159.861 171.821 177.506 1.00 71.67  ? 588 LYS A O     1 
ATOM   4887 C  CB    . LYS A 1 598 ? 163.248 171.494 176.974 1.00 76.86  ? 588 LYS A CB    1 
ATOM   4888 C  CG    . LYS A 1 598 ? 164.456 171.536 176.057 1.00 81.14  ? 588 LYS A CG    1 
ATOM   4889 C  CD    . LYS A 1 598 ? 165.729 171.177 176.806 1.00 83.64  ? 588 LYS A CD    1 
ATOM   4890 C  CE    . LYS A 1 598 ? 166.064 172.211 177.866 1.00 81.40  ? 588 LYS A CE    1 
ATOM   4891 N  NZ    . LYS A 1 598 ? 167.426 171.996 178.428 1.00 74.26  ? 588 LYS A NZ    1 
ATOM   4892 N  N     . TYR A 1 599 ? 160.725 169.960 176.580 1.00 67.70  ? 589 TYR A N     1 
ATOM   4893 C  CA    . TYR A 1 599 ? 159.713 169.058 177.109 1.00 63.29  ? 589 TYR A CA    1 
ATOM   4894 C  C     . TYR A 1 599 ? 160.215 168.480 178.421 1.00 66.38  ? 589 TYR A C     1 
ATOM   4895 O  O     . TYR A 1 599 ? 161.306 167.905 178.469 1.00 71.38  ? 589 TYR A O     1 
ATOM   4896 C  CB    . TYR A 1 599 ? 159.416 167.917 176.139 1.00 65.61  ? 589 TYR A CB    1 
ATOM   4897 C  CG    . TYR A 1 599 ? 158.838 168.318 174.808 1.00 67.15  ? 589 TYR A CG    1 
ATOM   4898 C  CD1   . TYR A 1 599 ? 157.552 168.819 174.711 1.00 64.05  ? 589 TYR A CD1   1 
ATOM   4899 C  CD2   . TYR A 1 599 ? 159.572 168.167 173.644 1.00 66.27  ? 589 TYR A CD2   1 
ATOM   4900 C  CE1   . TYR A 1 599 ? 157.022 169.174 173.493 1.00 69.63  ? 589 TYR A CE1   1 
ATOM   4901 C  CE2   . TYR A 1 599 ? 159.052 168.519 172.425 1.00 65.53  ? 589 TYR A CE2   1 
ATOM   4902 C  CZ    . TYR A 1 599 ? 157.779 169.022 172.355 1.00 67.73  ? 589 TYR A CZ    1 
ATOM   4903 O  OH    . TYR A 1 599 ? 157.262 169.371 171.135 1.00 67.41  ? 589 TYR A OH    1 
ATOM   4904 N  N     . THR A 1 600 ? 159.422 168.619 179.477 1.00 68.37  ? 590 THR A N     1 
ATOM   4905 C  CA    . THR A 1 600 ? 159.686 167.831 180.665 1.00 67.91  ? 590 THR A CA    1 
ATOM   4906 C  C     . THR A 1 600 ? 159.332 166.371 180.394 1.00 70.86  ? 590 THR A C     1 
ATOM   4907 O  O     . THR A 1 600 ? 158.852 166.010 179.317 1.00 68.95  ? 590 THR A O     1 
ATOM   4908 C  CB    . THR A 1 600 ? 158.897 168.362 181.858 1.00 64.86  ? 590 THR A CB    1 
ATOM   4909 O  OG1   . THR A 1 600 ? 157.542 167.911 181.773 1.00 67.74  ? 590 THR A OG1   1 
ATOM   4910 C  CG2   . THR A 1 600 ? 158.917 169.874 181.873 1.00 65.64  ? 590 THR A CG2   1 
ATOM   4911 N  N     . GLU A 1 601 ? 159.581 165.518 181.388 1.00 70.35  ? 591 GLU A N     1 
ATOM   4912 C  CA    . GLU A 1 601 ? 159.248 164.106 181.241 1.00 67.41  ? 591 GLU A CA    1 
ATOM   4913 C  C     . GLU A 1 601 ? 157.759 163.927 180.994 1.00 64.58  ? 591 GLU A C     1 
ATOM   4914 O  O     . GLU A 1 601 ? 157.348 163.175 180.102 1.00 67.52  ? 591 GLU A O     1 
ATOM   4915 C  CB    . GLU A 1 601 ? 159.681 163.335 182.486 1.00 71.61  ? 591 GLU A CB    1 
ATOM   4916 C  CG    . GLU A 1 601 ? 159.393 161.847 182.424 1.00 77.93  ? 591 GLU A CG    1 
ATOM   4917 C  CD    . GLU A 1 601 ? 159.092 161.251 183.786 1.00 84.50  ? 591 GLU A CD    1 
ATOM   4918 O  OE1   . GLU A 1 601 ? 158.657 162.003 184.684 1.00 78.00  ? 591 GLU A OE1   1 
ATOM   4919 O  OE2   . GLU A 1 601 ? 159.287 160.030 183.958 1.00 82.11  ? 591 GLU A OE2   1 
ATOM   4920 N  N     . LYS A 1 602 ? 156.935 164.640 181.765 1.00 65.23  ? 592 LYS A N     1 
ATOM   4921 C  CA    . LYS A 1 602 ? 155.487 164.491 181.669 1.00 65.17  ? 592 LYS A CA    1 
ATOM   4922 C  C     . LYS A 1 602 ? 154.983 164.875 180.283 1.00 63.96  ? 592 LYS A C     1 
ATOM   4923 O  O     . LYS A 1 602 ? 154.197 164.144 179.671 1.00 58.11  ? 592 LYS A O     1 
ATOM   4924 C  CB    . LYS A 1 602 ? 154.817 165.341 182.748 1.00 58.58  ? 592 LYS A CB    1 
ATOM   4925 C  CG    . LYS A 1 602 ? 153.343 165.062 182.952 1.00 61.80  ? 592 LYS A CG    1 
ATOM   4926 C  CD    . LYS A 1 602 ? 152.780 165.915 184.072 1.00 62.55  ? 592 LYS A CD    1 
ATOM   4927 C  CE    . LYS A 1 602 ? 151.300 165.652 184.277 1.00 65.81  ? 592 LYS A CE    1 
ATOM   4928 N  NZ    . LYS A 1 602 ? 150.696 166.612 185.242 1.00 63.72  ? 592 LYS A NZ    1 
ATOM   4929 N  N     . GLY A 1 603 ? 155.433 166.021 179.765 1.00 65.89  ? 593 GLY A N     1 
ATOM   4930 C  CA    . GLY A 1 603 ? 154.998 166.446 178.444 1.00 61.02  ? 593 GLY A CA    1 
ATOM   4931 C  C     . GLY A 1 603 ? 155.550 165.582 177.327 1.00 56.69  ? 593 GLY A C     1 
ATOM   4932 O  O     . GLY A 1 603 ? 154.835 165.247 176.375 1.00 51.98  ? 593 GLY A O     1 
ATOM   4933 N  N     . ALA A 1 604 ? 156.831 165.223 177.416 1.00 57.42  ? 594 ALA A N     1 
ATOM   4934 C  CA    . ALA A 1 604 ? 157.430 164.379 176.392 1.00 50.33  ? 594 ALA A CA    1 
ATOM   4935 C  C     . ALA A 1 604 ? 156.792 163.002 176.350 1.00 46.47  ? 594 ALA A C     1 
ATOM   4936 O  O     . ALA A 1 604 ? 156.828 162.350 175.303 1.00 49.37  ? 594 ALA A O     1 
ATOM   4937 C  CB    . ALA A 1 604 ? 158.935 164.253 176.621 1.00 52.94  ? 594 ALA A CB    1 
ATOM   4938 N  N     . MET A 1 605 ? 156.207 162.546 177.456 1.00 47.01  ? 595 MET A N     1 
ATOM   4939 C  CA    . MET A 1 605 ? 155.476 161.288 177.440 1.00 45.07  ? 595 MET A CA    1 
ATOM   4940 C  C     . MET A 1 605 ? 154.010 161.463 177.069 1.00 48.67  ? 595 MET A C     1 
ATOM   4941 O  O     . MET A 1 605 ? 153.402 160.533 176.533 1.00 49.95  ? 595 MET A O     1 
ATOM   4942 C  CB    . MET A 1 605 ? 155.590 160.594 178.796 1.00 41.95  ? 595 MET A CB    1 
ATOM   4943 C  CG    . MET A 1 605 ? 155.193 159.136 178.765 1.00 40.50  ? 595 MET A CG    1 
ATOM   4944 S  SD    . MET A 1 605 ? 156.295 158.128 177.758 1.00 58.21  ? 595 MET A SD    1 
ATOM   4945 C  CE    . MET A 1 605 ? 157.858 158.393 178.585 1.00 54.55  ? 595 MET A CE    1 
ATOM   4946 N  N     . LYS A 1 606 ? 153.421 162.629 177.334 1.00 48.79  ? 596 LYS A N     1 
ATOM   4947 C  CA    . LYS A 1 606 ? 152.079 162.902 176.827 1.00 47.19  ? 596 LYS A CA    1 
ATOM   4948 C  C     . LYS A 1 606 ? 152.074 162.918 175.306 1.00 46.67  ? 596 LYS A C     1 
ATOM   4949 O  O     . LYS A 1 606 ? 151.139 162.414 174.666 1.00 45.34  ? 596 LYS A O     1 
ATOM   4950 C  CB    . LYS A 1 606 ? 151.574 164.232 177.385 1.00 55.00  ? 596 LYS A CB    1 
ATOM   4951 C  CG    . LYS A 1 606 ? 150.119 164.537 177.088 1.00 50.26  ? 596 LYS A CG    1 
ATOM   4952 C  CD    . LYS A 1 606 ? 149.200 163.851 178.081 1.00 50.49  ? 596 LYS A CD    1 
ATOM   4953 C  CE    . LYS A 1 606 ? 147.780 164.372 177.964 1.00 52.85  ? 596 LYS A CE    1 
ATOM   4954 N  NZ    . LYS A 1 606 ? 146.840 163.629 178.843 1.00 49.79  ? 596 LYS A NZ    1 
ATOM   4955 N  N     . VAL A 1 607 ? 153.123 163.490 174.712 1.00 46.71  ? 597 VAL A N     1 
ATOM   4956 C  CA    . VAL A 1 607 ? 153.262 163.478 173.258 1.00 43.65  ? 597 VAL A CA    1 
ATOM   4957 C  C     . VAL A 1 607 ? 153.329 162.044 172.747 1.00 42.82  ? 597 VAL A C     1 
ATOM   4958 O  O     . VAL A 1 607 ? 152.694 161.688 171.747 1.00 44.46  ? 597 VAL A O     1 
ATOM   4959 C  CB    . VAL A 1 607 ? 154.500 164.286 172.835 1.00 44.90  ? 597 VAL A CB    1 
ATOM   4960 C  CG1   . VAL A 1 607 ? 154.920 163.927 171.424 1.00 41.92  ? 597 VAL A CG1   1 
ATOM   4961 C  CG2   . VAL A 1 607 ? 154.217 165.762 172.940 1.00 54.48  ? 597 VAL A CG2   1 
ATOM   4962 N  N     . LYS A 1 608 ? 154.107 161.201 173.427 1.00 39.30  ? 598 LYS A N     1 
ATOM   4963 C  CA    . LYS A 1 608 ? 154.205 159.805 173.030 1.00 34.21  ? 598 LYS A CA    1 
ATOM   4964 C  C     . LYS A 1 608 ? 152.881 159.076 173.183 1.00 35.12  ? 598 LYS A C     1 
ATOM   4965 O  O     . LYS A 1 608 ? 152.550 158.239 172.346 1.00 40.40  ? 598 LYS A O     1 
ATOM   4966 C  CB    . LYS A 1 608 ? 155.301 159.095 173.825 1.00 38.32  ? 598 LYS A CB    1 
ATOM   4967 C  CG    . LYS A 1 608 ? 156.700 159.630 173.577 1.00 36.24  ? 598 LYS A CG    1 
ATOM   4968 C  CD    . LYS A 1 608 ? 157.135 159.291 172.164 1.00 36.84  ? 598 LYS A CD    1 
ATOM   4969 C  CE    . LYS A 1 608 ? 158.526 159.798 171.845 1.00 39.62  ? 598 LYS A CE    1 
ATOM   4970 N  NZ    . LYS A 1 608 ? 159.563 159.070 172.608 1.00 47.30  ? 598 LYS A NZ    1 
ATOM   4971 N  N     . ASN A 1 609 ? 152.119 159.357 174.238 1.00 34.49  ? 599 ASN A N     1 
ATOM   4972 C  CA    . ASN A 1 609 ? 150.817 158.709 174.381 1.00 34.60  ? 599 ASN A CA    1 
ATOM   4973 C  C     . ASN A 1 609 ? 149.885 159.095 173.242 1.00 36.94  ? 599 ASN A C     1 
ATOM   4974 O  O     . ASN A 1 609 ? 149.199 158.237 172.666 1.00 40.53  ? 599 ASN A O     1 
ATOM   4975 C  CB    . ASN A 1 609 ? 150.192 159.065 175.726 1.00 34.65  ? 599 ASN A CB    1 
ATOM   4976 C  CG    . ASN A 1 609 ? 149.264 157.985 176.236 1.00 37.84  ? 599 ASN A CG    1 
ATOM   4977 O  OD1   . ASN A 1 609 ? 148.967 157.027 175.528 1.00 40.97  ? 599 ASN A OD1   1 
ATOM   4978 N  ND2   . ASN A 1 609 ? 148.800 158.134 177.467 1.00 37.66  ? 599 ASN A ND2   1 
ATOM   4979 N  N     . ALA A 1 610 ? 149.853 160.383 172.896 1.00 40.57  ? 600 ALA A N     1 
ATOM   4980 C  CA    . ALA A 1 610 ? 149.001 160.832 171.801 1.00 36.59  ? 600 ALA A CA    1 
ATOM   4981 C  C     . ALA A 1 610 ? 149.420 160.199 170.481 1.00 34.58  ? 600 ALA A C     1 
ATOM   4982 O  O     . ALA A 1 610 ? 148.574 159.739 169.708 1.00 39.16  ? 600 ALA A O     1 
ATOM   4983 C  CB    . ALA A 1 610 ? 149.032 162.354 171.704 1.00 42.18  ? 600 ALA A CB    1 
ATOM   4984 N  N     . ASN A 1 611 ? 150.728 160.165 170.204 1.00 35.59  ? 601 ASN A N     1 
ATOM   4985 C  CA    . ASN A 1 611 ? 151.212 159.529 168.981 1.00 33.93  ? 601 ASN A CA    1 
ATOM   4986 C  C     . ASN A 1 611 ? 150.891 158.042 168.963 1.00 33.27  ? 601 ASN A C     1 
ATOM   4987 O  O     . ASN A 1 611 ? 150.527 157.492 167.921 1.00 37.59  ? 601 ASN A O     1 
ATOM   4988 C  CB    . ASN A 1 611 ? 152.716 159.738 168.831 1.00 35.13  ? 601 ASN A CB    1 
ATOM   4989 C  CG    . ASN A 1 611 ? 153.066 161.131 168.390 1.00 42.48  ? 601 ASN A CG    1 
ATOM   4990 O  OD1   . ASN A 1 611 ? 152.239 162.032 168.442 1.00 47.15  ? 601 ASN A OD1   1 
ATOM   4991 N  ND2   . ASN A 1 611 ? 154.300 161.319 167.945 1.00 41.59  ? 601 ASN A ND2   1 
ATOM   4992 N  N     . PHE A 1 612 ? 151.043 157.374 170.105 1.00 31.81  ? 602 PHE A N     1 
ATOM   4993 C  CA    . PHE A 1 612 ? 150.761 155.950 170.194 1.00 27.36  ? 602 PHE A CA    1 
ATOM   4994 C  C     . PHE A 1 612 ? 149.305 155.665 169.876 1.00 32.91  ? 602 PHE A C     1 
ATOM   4995 O  O     . PHE A 1 612 ? 148.994 154.694 169.179 1.00 37.34  ? 602 PHE A O     1 
ATOM   4996 C  CB    . PHE A 1 612 ? 151.120 155.454 171.592 1.00 26.38  ? 602 PHE A CB    1 
ATOM   4997 C  CG    . PHE A 1 612 ? 151.043 153.968 171.760 1.00 28.11  ? 602 PHE A CG    1 
ATOM   4998 C  CD1   . PHE A 1 612 ? 152.125 153.168 171.463 1.00 28.25  ? 602 PHE A CD1   1 
ATOM   4999 C  CD2   . PHE A 1 612 ? 149.896 153.373 172.247 1.00 29.31  ? 602 PHE A CD2   1 
ATOM   5000 C  CE1   . PHE A 1 612 ? 152.057 151.807 171.631 1.00 28.14  ? 602 PHE A CE1   1 
ATOM   5001 C  CE2   . PHE A 1 612 ? 149.826 152.016 172.415 1.00 27.49  ? 602 PHE A CE2   1 
ATOM   5002 C  CZ    . PHE A 1 612 ? 150.906 151.231 172.109 1.00 26.52  ? 602 PHE A CZ    1 
ATOM   5003 N  N     . PHE A 1 613 ? 148.394 156.499 170.378 1.00 32.88  ? 603 PHE A N     1 
ATOM   5004 C  CA    . PHE A 1 613 ? 146.982 156.280 170.080 1.00 33.51  ? 603 PHE A CA    1 
ATOM   5005 C  C     . PHE A 1 613 ? 146.649 156.643 168.637 1.00 39.98  ? 603 PHE A C     1 
ATOM   5006 O  O     . PHE A 1 613 ? 145.836 155.971 167.997 1.00 43.23  ? 603 PHE A O     1 
ATOM   5007 C  CB    . PHE A 1 613 ? 146.102 157.070 171.043 1.00 38.11  ? 603 PHE A CB    1 
ATOM   5008 C  CG    . PHE A 1 613 ? 144.635 156.932 170.762 1.00 46.54  ? 603 PHE A CG    1 
ATOM   5009 C  CD1   . PHE A 1 613 ? 143.940 155.814 171.182 1.00 48.50  ? 603 PHE A CD1   1 
ATOM   5010 C  CD2   . PHE A 1 613 ? 143.953 157.909 170.069 1.00 49.54  ? 603 PHE A CD2   1 
ATOM   5011 C  CE1   . PHE A 1 613 ? 142.601 155.676 170.921 1.00 49.58  ? 603 PHE A CE1   1 
ATOM   5012 C  CE2   . PHE A 1 613 ? 142.613 157.773 169.808 1.00 51.72  ? 603 PHE A CE2   1 
ATOM   5013 C  CZ    . PHE A 1 613 ? 141.938 156.656 170.237 1.00 53.11  ? 603 PHE A CZ    1 
ATOM   5014 N  N     . ASN A 1 614 ? 147.257 157.702 168.104 1.00 40.83  ? 604 ASN A N     1 
ATOM   5015 C  CA    . ASN A 1 614 ? 146.908 158.138 166.757 1.00 35.27  ? 604 ASN A CA    1 
ATOM   5016 C  C     . ASN A 1 614 ? 147.472 157.214 165.688 1.00 37.86  ? 604 ASN A C     1 
ATOM   5017 O  O     . ASN A 1 614 ? 146.860 157.057 164.628 1.00 48.01  ? 604 ASN A O     1 
ATOM   5018 C  CB    . ASN A 1 614 ? 147.398 159.566 166.522 1.00 35.69  ? 604 ASN A CB    1 
ATOM   5019 C  CG    . ASN A 1 614 ? 146.686 160.573 167.391 1.00 44.56  ? 604 ASN A CG    1 
ATOM   5020 O  OD1   . ASN A 1 614 ? 145.615 160.302 167.923 1.00 45.98  ? 604 ASN A OD1   1 
ATOM   5021 N  ND2   . ASN A 1 614 ? 147.281 161.745 167.542 1.00 46.37  ? 604 ASN A ND2   1 
ATOM   5022 N  N     . LEU A 1 615 ? 148.632 156.604 165.934 1.00 38.29  ? 605 LEU A N     1 
ATOM   5023 C  CA    . LEU A 1 615 ? 149.293 155.822 164.896 1.00 38.10  ? 605 LEU A CA    1 
ATOM   5024 C  C     . LEU A 1 615 ? 148.576 154.506 164.629 1.00 42.30  ? 605 LEU A C     1 
ATOM   5025 O  O     . LEU A 1 615 ? 148.647 153.985 163.513 1.00 49.38  ? 605 LEU A O     1 
ATOM   5026 C  CB    . LEU A 1 615 ? 150.750 155.574 165.284 1.00 32.77  ? 605 LEU A CB    1 
ATOM   5027 C  CG    . LEU A 1 615 ? 151.659 154.865 164.279 1.00 34.49  ? 605 LEU A CG    1 
ATOM   5028 C  CD1   . LEU A 1 615 ? 152.071 155.797 163.152 1.00 34.17  ? 605 LEU A CD1   1 
ATOM   5029 C  CD2   . LEU A 1 615 ? 152.880 154.305 164.979 1.00 34.91  ? 605 LEU A CD2   1 
ATOM   5030 N  N     . MET A 1 616 ? 147.888 153.947 165.626 1.00 42.51  ? 606 MET A N     1 
ATOM   5031 C  CA    . MET A 1 616 ? 147.115 152.738 165.374 1.00 42.11  ? 606 MET A CA    1 
ATOM   5032 C  C     . MET A 1 616 ? 145.880 153.023 164.534 1.00 53.57  ? 606 MET A C     1 
ATOM   5033 O  O     . MET A 1 616 ? 145.294 152.089 163.976 1.00 58.48  ? 606 MET A O     1 
ATOM   5034 C  CB    . MET A 1 616 ? 146.708 152.068 166.687 1.00 35.74  ? 606 MET A CB    1 
ATOM   5035 C  CG    . MET A 1 616 ? 145.918 152.957 167.617 1.00 41.11  ? 606 MET A CG    1 
ATOM   5036 S  SD    . MET A 1 616 ? 145.019 152.051 168.882 1.00 54.58  ? 606 MET A SD    1 
ATOM   5037 C  CE    . MET A 1 616 ? 143.611 151.466 167.948 1.00 47.63  ? 606 MET A CE    1 
ATOM   5038 N  N     . MET A 1 617 ? 145.459 154.286 164.449 1.00 49.53  ? 607 MET A N     1 
ATOM   5039 C  CA    . MET A 1 617 ? 144.414 154.652 163.501 1.00 50.93  ? 607 MET A CA    1 
ATOM   5040 C  C     . MET A 1 617 ? 144.881 154.451 162.068 1.00 54.68  ? 607 MET A C     1 
ATOM   5041 O  O     . MET A 1 617 ? 144.148 153.900 161.240 1.00 56.70  ? 607 MET A O     1 
ATOM   5042 C  CB    . MET A 1 617 ? 144.000 156.107 163.706 1.00 57.63  ? 607 MET A CB    1 
ATOM   5043 C  CG    . MET A 1 617 ? 143.333 156.413 165.025 1.00 61.49  ? 607 MET A CG    1 
ATOM   5044 S  SD    . MET A 1 617 ? 141.762 155.566 165.210 1.00 81.53  ? 607 MET A SD    1 
ATOM   5045 C  CE    . MET A 1 617 ? 141.388 155.990 166.899 1.00 72.06  ? 607 MET A CE    1 
ATOM   5046 N  N     . LYS A 1 618 ? 146.095 154.891 161.760 1.00 53.22  ? 608 LYS A N     1 
ATOM   5047 C  CA    . LYS A 1 618 ? 146.614 154.892 160.403 1.00 52.47  ? 608 LYS A CA    1 
ATOM   5048 C  C     . LYS A 1 618 ? 147.489 153.689 160.092 1.00 51.38  ? 608 LYS A C     1 
ATOM   5049 O  O     . LYS A 1 618 ? 147.986 153.583 158.968 1.00 58.15  ? 608 LYS A O     1 
ATOM   5050 C  CB    . LYS A 1 618 ? 147.409 156.175 160.154 1.00 53.38  ? 608 LYS A CB    1 
ATOM   5051 C  CG    . LYS A 1 618 ? 146.642 157.446 160.466 1.00 54.75  ? 608 LYS A CG    1 
ATOM   5052 C  CD    . LYS A 1 618 ? 145.751 157.844 159.305 1.00 59.09  ? 608 LYS A CD    1 
ATOM   5053 C  CE    . LYS A 1 618 ? 145.168 159.231 159.498 1.00 56.20  ? 608 LYS A CE    1 
ATOM   5054 N  NZ    . LYS A 1 618 ? 144.583 159.757 158.233 1.00 52.24  ? 608 LYS A NZ    1 
ATOM   5055 N  N     . SER A 1 619 ? 147.700 152.786 161.049 1.00 47.80  ? 609 SER A N     1 
ATOM   5056 C  CA    . SER A 1 619 ? 148.611 151.671 160.853 1.00 51.61  ? 609 SER A CA    1 
ATOM   5057 C  C     . SER A 1 619 ? 147.957 150.305 160.941 1.00 51.14  ? 609 SER A C     1 
ATOM   5058 O  O     . SER A 1 619 ? 148.543 149.334 160.453 1.00 54.18  ? 609 SER A O     1 
ATOM   5059 C  CB    . SER A 1 619 ? 149.758 151.725 161.876 1.00 48.97  ? 609 SER A CB    1 
ATOM   5060 O  OG    . SER A 1 619 ? 150.553 152.882 161.695 1.00 44.42  ? 609 SER A OG    1 
ATOM   5061 N  N     . LEU A 1 620 ? 146.779 150.194 161.541 1.00 46.13  ? 610 LEU A N     1 
ATOM   5062 C  CA    . LEU A 1 620 ? 146.095 148.916 161.649 1.00 47.15  ? 610 LEU A CA    1 
ATOM   5063 C  C     . LEU A 1 620 ? 145.032 148.735 160.577 1.00 52.18  ? 610 LEU A C     1 
ATOM   5064 O  O     . LEU A 1 620 ? 144.223 147.809 160.675 1.00 50.74  ? 610 LEU A O     1 
ATOM   5065 C  CB    . LEU A 1 620 ? 145.486 148.760 163.039 1.00 46.63  ? 610 LEU A CB    1 
ATOM   5066 C  CG    . LEU A 1 620 ? 146.504 148.444 164.135 1.00 44.78  ? 610 LEU A CG    1 
ATOM   5067 C  CD1   . LEU A 1 620 ? 145.928 148.731 165.498 1.00 42.79  ? 610 LEU A CD1   1 
ATOM   5068 C  CD2   . LEU A 1 620 ? 146.952 147.004 164.049 1.00 38.91  ? 610 LEU A CD2   1 
ATOM   5069 N  N     . HIS A 1 621 ? 145.008 149.604 159.569 1.00 53.23  ? 611 HIS A N     1 
ATOM   5070 C  CA    . HIS A 1 621 ? 144.164 149.445 158.386 1.00 52.83  ? 611 HIS A CA    1 
ATOM   5071 C  C     . HIS A 1 621 ? 142.699 149.226 158.768 1.00 59.90  ? 611 HIS A C     1 
ATOM   5072 O  O     . HIS A 1 621 ? 142.072 148.230 158.406 1.00 61.11  ? 611 HIS A O     1 
ATOM   5073 C  CB    . HIS A 1 621 ? 144.680 148.303 157.508 1.00 48.89  ? 611 HIS A CB    1 
ATOM   5074 C  CG    . HIS A 1 621 ? 146.037 148.550 156.928 1.00 50.62  ? 611 HIS A CG    1 
ATOM   5075 N  ND1   . HIS A 1 621 ? 146.621 147.703 156.011 1.00 49.68  ? 611 HIS A ND1   1 
ATOM   5076 C  CD2   . HIS A 1 621 ? 146.925 149.552 157.130 1.00 44.91  ? 611 HIS A CD2   1 
ATOM   5077 C  CE1   . HIS A 1 621 ? 147.808 148.173 155.673 1.00 40.54  ? 611 HIS A CE1   1 
ATOM   5078 N  NE2   . HIS A 1 621 ? 148.017 149.293 156.340 1.00 40.57  ? 611 HIS A NE2   1 
ATOM   5079 N  N     . PHE A 1 622 ? 142.159 150.180 159.524 1.00 58.61  ? 612 PHE A N     1 
ATOM   5080 C  CA    . PHE A 1 622 ? 140.771 150.094 159.958 1.00 56.75  ? 612 PHE A CA    1 
ATOM   5081 C  C     . PHE A 1 622 ? 139.782 150.568 158.905 1.00 64.50  ? 612 PHE A C     1 
ATOM   5082 O  O     . PHE A 1 622 ? 138.572 150.400 159.096 1.00 62.80  ? 612 PHE A O     1 
ATOM   5083 C  CB    . PHE A 1 622 ? 140.571 150.883 161.249 1.00 52.83  ? 612 PHE A CB    1 
ATOM   5084 C  CG    . PHE A 1 622 ? 141.114 150.193 162.457 1.00 56.55  ? 612 PHE A CG    1 
ATOM   5085 C  CD1   . PHE A 1 622 ? 140.860 148.849 162.666 1.00 56.77  ? 612 PHE A CD1   1 
ATOM   5086 C  CD2   . PHE A 1 622 ? 141.860 150.879 163.391 1.00 60.84  ? 612 PHE A CD2   1 
ATOM   5087 C  CE1   . PHE A 1 622 ? 141.353 148.205 163.771 1.00 47.32  ? 612 PHE A CE1   1 
ATOM   5088 C  CE2   . PHE A 1 622 ? 142.350 150.237 164.503 1.00 56.40  ? 612 PHE A CE2   1 
ATOM   5089 C  CZ    . PHE A 1 622 ? 142.095 148.897 164.689 1.00 50.62  ? 612 PHE A CZ    1 
ATOM   5090 N  N     . ALA A 1 623 ? 140.255 151.160 157.814 1.00 70.56  ? 613 ALA A N     1 
ATOM   5091 C  CA    . ALA A 1 623 ? 139.416 151.458 156.664 1.00 67.20  ? 613 ALA A CA    1 
ATOM   5092 C  C     . ALA A 1 623 ? 139.563 150.410 155.570 1.00 64.50  ? 613 ALA A C     1 
ATOM   5093 O  O     . ALA A 1 623 ? 139.061 150.607 154.460 1.00 63.47  ? 613 ALA A O     1 
ATOM   5094 C  CB    . ALA A 1 623 ? 139.735 152.851 156.121 1.00 56.19  ? 613 ALA A CB    1 
ATOM   5095 N  N     . SER A 1 624 ? 140.258 149.310 155.861 1.00 62.20  ? 614 SER A N     1 
ATOM   5096 C  CA    . SER A 1 624 ? 140.370 148.170 154.964 1.00 63.15  ? 614 SER A CA    1 
ATOM   5097 C  C     . SER A 1 624 ? 139.747 146.915 155.551 1.00 63.10  ? 614 SER A C     1 
ATOM   5098 O  O     . SER A 1 624 ? 139.811 145.854 154.920 1.00 63.16  ? 614 SER A O     1 
ATOM   5099 C  CB    . SER A 1 624 ? 141.841 147.895 154.624 1.00 66.57  ? 614 SER A CB    1 
ATOM   5100 O  OG    . SER A 1 624 ? 142.465 149.040 154.077 1.00 65.03  ? 614 SER A OG    1 
ATOM   5101 N  N     . VAL A 1 625 ? 139.169 147.002 156.749 1.00 61.77  ? 615 VAL A N     1 
ATOM   5102 C  CA    . VAL A 1 625 ? 138.515 145.853 157.367 1.00 60.44  ? 615 VAL A CA    1 
ATOM   5103 C  C     . VAL A 1 625 ? 137.329 145.400 156.524 1.00 59.70  ? 615 VAL A C     1 
ATOM   5104 O  O     . VAL A 1 625 ? 137.138 144.199 156.275 1.00 62.20  ? 615 VAL A O     1 
ATOM   5105 C  CB    . VAL A 1 625 ? 138.096 146.216 158.804 1.00 59.31  ? 615 VAL A CB    1 
ATOM   5106 C  CG1   . VAL A 1 625 ? 137.061 145.257 159.321 1.00 49.66  ? 615 VAL A CG1   1 
ATOM   5107 C  CG2   . VAL A 1 625 ? 139.308 146.242 159.719 1.00 49.12  ? 615 VAL A CG2   1 
ATOM   5108 N  N     . LYS A 1 626 ? 136.523 146.359 156.062 1.00 61.77  ? 616 LYS A N     1 
ATOM   5109 C  CA    . LYS A 1 626 ? 135.413 146.046 155.171 1.00 63.02  ? 616 LYS A CA    1 
ATOM   5110 C  C     . LYS A 1 626 ? 135.896 145.335 153.918 1.00 63.65  ? 616 LYS A C     1 
ATOM   5111 O  O     . LYS A 1 626 ? 135.225 144.430 153.416 1.00 61.59  ? 616 LYS A O     1 
ATOM   5112 C  CB    . LYS A 1 626 ? 134.666 147.327 154.804 1.00 58.91  ? 616 LYS A CB    1 
ATOM   5113 C  CG    . LYS A 1 626 ? 135.582 148.433 154.305 1.00 63.08  ? 616 LYS A CG    1 
ATOM   5114 C  CD    . LYS A 1 626 ? 134.813 149.545 153.632 1.00 62.19  ? 616 LYS A CD    1 
ATOM   5115 C  CE    . LYS A 1 626 ? 135.754 150.634 153.154 1.00 59.77  ? 616 LYS A CE    1 
ATOM   5116 N  NZ    . LYS A 1 626 ? 136.815 150.089 152.259 1.00 58.23  ? 616 LYS A NZ    1 
ATOM   5117 N  N     . ASP A 1 627 ? 137.062 145.727 153.401 1.00 66.76  ? 617 ASP A N     1 
ATOM   5118 C  CA    . ASP A 1 627 ? 137.610 145.077 152.216 1.00 62.83  ? 617 ASP A CA    1 
ATOM   5119 C  C     . ASP A 1 627 ? 137.919 143.609 152.486 1.00 58.73  ? 617 ASP A C     1 
ATOM   5120 O  O     . ASP A 1 627 ? 137.641 142.740 151.651 1.00 59.47  ? 617 ASP A O     1 
ATOM   5121 C  CB    . ASP A 1 627 ? 138.862 145.819 151.751 1.00 65.77  ? 617 ASP A CB    1 
ATOM   5122 C  CG    . ASP A 1 627 ? 138.613 147.298 151.524 1.00 69.08  ? 617 ASP A CG    1 
ATOM   5123 O  OD1   . ASP A 1 627 ? 137.464 147.745 151.710 1.00 65.07  ? 617 ASP A OD1   1 
ATOM   5124 O  OD2   . ASP A 1 627 ? 139.565 148.014 151.154 1.00 67.30  ? 617 ASP A OD2   1 
ATOM   5125 N  N     . GLU A 1 628 ? 138.498 143.311 153.651 1.00 58.03  ? 618 GLU A N     1 
ATOM   5126 C  CA    . GLU A 1 628 ? 138.805 141.924 153.985 1.00 58.14  ? 618 GLU A CA    1 
ATOM   5127 C  C     . GLU A 1 628 ? 137.537 141.100 154.163 1.00 55.50  ? 618 GLU A C     1 
ATOM   5128 O  O     . GLU A 1 628 ? 137.480 139.945 153.724 1.00 51.72  ? 618 GLU A O     1 
ATOM   5129 C  CB    . GLU A 1 628 ? 139.678 141.863 155.238 1.00 58.09  ? 618 GLU A CB    1 
ATOM   5130 C  CG    . GLU A 1 628 ? 140.860 142.817 155.213 1.00 58.66  ? 618 GLU A CG    1 
ATOM   5131 C  CD    . GLU A 1 628 ? 141.864 142.485 154.122 1.00 65.91  ? 618 GLU A CD    1 
ATOM   5132 O  OE1   . GLU A 1 628 ? 141.889 141.324 153.664 1.00 63.89  ? 618 GLU A OE1   1 
ATOM   5133 O  OE2   . GLU A 1 628 ? 142.623 143.388 153.712 1.00 68.27  ? 618 GLU A OE2   1 
ATOM   5134 N  N     . PHE A 1 629 ? 136.506 141.670 154.797 1.00 58.21  ? 619 PHE A N     1 
ATOM   5135 C  CA    . PHE A 1 629 ? 135.239 140.944 154.877 1.00 56.16  ? 619 PHE A CA    1 
ATOM   5136 C  C     . PHE A 1 629 ? 134.605 140.739 153.504 1.00 61.89  ? 619 PHE A C     1 
ATOM   5137 O  O     . PHE A 1 629 ? 134.022 139.683 153.245 1.00 66.56  ? 619 PHE A O     1 
ATOM   5138 C  CB    . PHE A 1 629 ? 134.260 141.629 155.829 1.00 53.75  ? 619 PHE A CB    1 
ATOM   5139 C  CG    . PHE A 1 629 ? 134.615 141.476 157.275 1.00 48.93  ? 619 PHE A CG    1 
ATOM   5140 C  CD1   . PHE A 1 629 ? 134.314 140.295 157.934 1.00 49.05  ? 619 PHE A CD1   1 
ATOM   5141 C  CD2   . PHE A 1 629 ? 135.199 142.499 157.986 1.00 48.30  ? 619 PHE A CD2   1 
ATOM   5142 C  CE1   . PHE A 1 629 ? 134.618 140.126 159.261 1.00 39.62  ? 619 PHE A CE1   1 
ATOM   5143 C  CE2   . PHE A 1 629 ? 135.501 142.332 159.324 1.00 48.14  ? 619 PHE A CE2   1 
ATOM   5144 C  CZ    . PHE A 1 629 ? 135.207 141.144 159.960 1.00 41.66  ? 619 PHE A CZ    1 
ATOM   5145 N  N     . VAL A 1 630 ? 134.705 141.724 152.610 1.00 61.76  ? 620 VAL A N     1 
ATOM   5146 C  CA    . VAL A 1 630 ? 134.189 141.538 151.252 1.00 62.13  ? 620 VAL A CA    1 
ATOM   5147 C  C     . VAL A 1 630 ? 134.914 140.389 150.562 1.00 59.83  ? 620 VAL A C     1 
ATOM   5148 O  O     . VAL A 1 630 ? 134.293 139.519 149.936 1.00 58.37  ? 620 VAL A O     1 
ATOM   5149 C  CB    . VAL A 1 630 ? 134.307 142.841 150.441 1.00 65.63  ? 620 VAL A CB    1 
ATOM   5150 C  CG1   . VAL A 1 630 ? 133.903 142.598 149.001 1.00 66.29  ? 620 VAL A CG1   1 
ATOM   5151 C  CG2   . VAL A 1 630 ? 133.421 143.917 151.031 1.00 59.53  ? 620 VAL A CG2   1 
ATOM   5152 N  N     . LEU A 1 631 ? 136.243 140.368 150.674 1.00 61.66  ? 621 LEU A N     1 
ATOM   5153 C  CA    . LEU A 1 631 ? 137.019 139.315 150.031 1.00 65.30  ? 621 LEU A CA    1 
ATOM   5154 C  C     . LEU A 1 631 ? 136.681 137.947 150.609 1.00 61.30  ? 621 LEU A C     1 
ATOM   5155 O  O     . LEU A 1 631 ? 136.607 136.955 149.874 1.00 60.22  ? 621 LEU A O     1 
ATOM   5156 C  CB    . LEU A 1 631 ? 138.510 139.610 150.164 1.00 64.30  ? 621 LEU A CB    1 
ATOM   5157 C  CG    . LEU A 1 631 ? 138.972 140.844 149.384 1.00 65.99  ? 621 LEU A CG    1 
ATOM   5158 C  CD1   . LEU A 1 631 ? 140.480 141.027 149.486 1.00 63.07  ? 621 LEU A CD1   1 
ATOM   5159 C  CD2   . LEU A 1 631 ? 138.524 140.760 147.932 1.00 63.24  ? 621 LEU A CD2   1 
ATOM   5160 N  N     . LEU A 1 632 ? 136.478 137.867 151.925 1.00 60.17  ? 622 LEU A N     1 
ATOM   5161 C  CA    . LEU A 1 632 ? 136.051 136.605 152.515 1.00 54.81  ? 622 LEU A CA    1 
ATOM   5162 C  C     . LEU A 1 632 ? 134.634 136.233 152.115 1.00 59.75  ? 622 LEU A C     1 
ATOM   5163 O  O     . LEU A 1 632 ? 134.298 135.045 152.113 1.00 68.09  ? 622 LEU A O     1 
ATOM   5164 C  CB    . LEU A 1 632 ? 136.160 136.660 154.036 1.00 53.36  ? 622 LEU A CB    1 
ATOM   5165 C  CG    . LEU A 1 632 ? 137.568 136.757 154.612 1.00 46.40  ? 622 LEU A CG    1 
ATOM   5166 C  CD1   . LEU A 1 632 ? 137.496 136.948 156.101 1.00 41.89  ? 622 LEU A CD1   1 
ATOM   5167 C  CD2   . LEU A 1 632 ? 138.337 135.503 154.284 1.00 43.71  ? 622 LEU A CD2   1 
ATOM   5168 N  N     . SER A 1 633 ? 133.798 137.214 151.786 1.00 59.58  ? 623 SER A N     1 
ATOM   5169 C  CA    . SER A 1 633 ? 132.451 136.947 151.300 1.00 61.71  ? 623 SER A CA    1 
ATOM   5170 C  C     . SER A 1 633 ? 132.422 136.592 149.823 1.00 64.84  ? 623 SER A C     1 
ATOM   5171 O  O     . SER A 1 633 ? 131.385 136.141 149.329 1.00 65.84  ? 623 SER A O     1 
ATOM   5172 C  CB    . SER A 1 633 ? 131.547 138.151 151.559 1.00 63.64  ? 623 SER A CB    1 
ATOM   5173 O  OG    . SER A 1 633 ? 130.233 137.903 151.097 1.00 67.02  ? 623 SER A OG    1 
ATOM   5174 N  N     . ASN A 1 634 ? 133.525 136.798 149.110 1.00 68.14  ? 624 ASN A N     1 
ATOM   5175 C  CA    . ASN A 1 634 ? 133.643 136.345 147.730 1.00 59.93  ? 624 ASN A CA    1 
ATOM   5176 C  C     . ASN A 1 634 ? 133.640 134.828 147.596 1.00 58.96  ? 624 ASN A C     1 
ATOM   5177 O  O     . ASN A 1 634 ? 133.408 134.324 146.494 1.00 62.39  ? 624 ASN A O     1 
ATOM   5178 C  CB    . ASN A 1 634 ? 134.921 136.902 147.095 1.00 55.28  ? 624 ASN A CB    1 
ATOM   5179 C  CG    . ASN A 1 634 ? 134.767 138.332 146.634 1.00 61.41  ? 624 ASN A CG    1 
ATOM   5180 O  OD1   . ASN A 1 634 ? 133.754 138.977 146.897 1.00 63.64  ? 624 ASN A OD1   1 
ATOM   5181 N  ND2   . ASN A 1 634 ? 135.775 138.837 145.938 1.00 64.57  ? 624 ASN A ND2   1 
ATOM   5182 N  N     . ASN A 1 635 ? 133.899 134.091 148.679 1.00 60.62  ? 625 ASN A N     1 
ATOM   5183 C  CA    . ASN A 1 635 ? 133.900 132.635 148.619 1.00 65.58  ? 625 ASN A CA    1 
ATOM   5184 C  C     . ASN A 1 635 ? 133.244 132.002 149.842 1.00 67.93  ? 625 ASN A C     1 
ATOM   5185 O  O     . ASN A 1 635 ? 133.495 130.824 150.125 1.00 63.76  ? 625 ASN A O     1 
ATOM   5186 C  CB    . ASN A 1 635 ? 135.325 132.092 148.483 1.00 64.63  ? 625 ASN A CB    1 
ATOM   5187 C  CG    . ASN A 1 635 ? 135.965 132.452 147.161 1.00 67.30  ? 625 ASN A CG    1 
ATOM   5188 O  OD1   . ASN A 1 635 ? 135.420 132.161 146.096 1.00 70.85  ? 625 ASN A OD1   1 
ATOM   5189 N  ND2   . ASN A 1 635 ? 137.132 133.085 147.219 1.00 58.13  ? 625 ASN A ND2   1 
ATOM   5190 N  N     . GLY A 1 636 ? 132.409 132.743 150.576 1.00 67.42  ? 626 GLY A N     1 
ATOM   5191 C  CA    . GLY A 1 636 ? 131.851 132.273 151.822 1.00 65.45  ? 626 GLY A CA    1 
ATOM   5192 C  C     . GLY A 1 636 ? 130.330 132.323 151.837 1.00 69.16  ? 626 GLY A C     1 
ATOM   5193 O  O     . GLY A 1 636 ? 129.689 132.979 151.008 1.00 70.60  ? 626 GLY A O     1 
ATOM   5194 N  N     . LYS A 1 637 ? 129.759 131.615 152.813 1.00 68.77  ? 627 LYS A N     1 
ATOM   5195 C  CA    . LYS A 1 637 ? 128.312 131.506 152.945 1.00 66.05  ? 627 LYS A CA    1 
ATOM   5196 C  C     . LYS A 1 637 ? 127.665 132.781 153.466 1.00 64.82  ? 627 LYS A C     1 
ATOM   5197 O  O     . LYS A 1 637 ? 126.436 132.898 153.419 1.00 69.76  ? 627 LYS A O     1 
ATOM   5198 C  CB    . LYS A 1 637 ? 127.961 130.341 153.871 1.00 67.31  ? 627 LYS A CB    1 
ATOM   5199 C  CG    . LYS A 1 637 ? 128.617 129.028 153.483 1.00 69.08  ? 627 LYS A CG    1 
ATOM   5200 C  CD    . LYS A 1 637 ? 128.354 127.941 154.512 1.00 69.40  ? 627 LYS A CD    1 
ATOM   5201 C  CE    . LYS A 1 637 ? 128.945 126.612 154.065 1.00 62.10  ? 627 LYS A CE    1 
ATOM   5202 N  NZ    . LYS A 1 637 ? 128.726 125.532 155.065 1.00 61.00  ? 627 LYS A NZ    1 
ATOM   5203 N  N     . THR A 1 638 ? 128.452 133.728 153.961 1.00 65.41  ? 628 THR A N     1 
ATOM   5204 C  CA    . THR A 1 638 ? 127.943 134.973 154.515 1.00 60.18  ? 628 THR A CA    1 
ATOM   5205 C  C     . THR A 1 638 ? 128.239 136.134 153.575 1.00 62.02  ? 628 THR A C     1 
ATOM   5206 O  O     . THR A 1 638 ? 129.197 136.112 152.802 1.00 67.84  ? 628 THR A O     1 
ATOM   5207 C  CB    . THR A 1 638 ? 128.557 135.237 155.892 1.00 61.06  ? 628 THR A CB    1 
ATOM   5208 O  OG1   . THR A 1 638 ? 128.557 134.023 156.651 1.00 64.83  ? 628 THR A OG1   1 
ATOM   5209 C  CG2   . THR A 1 638 ? 127.776 136.291 156.644 1.00 61.60  ? 628 THR A CG2   1 
ATOM   5210 N  N     . GLN A 1 639 ? 127.392 137.153 153.645 1.00 64.10  ? 629 GLN A N     1 
ATOM   5211 C  CA    . GLN A 1 639 ? 127.554 138.350 152.839 1.00 67.92  ? 629 GLN A CA    1 
ATOM   5212 C  C     . GLN A 1 639 ? 127.766 139.546 153.753 1.00 67.11  ? 629 GLN A C     1 
ATOM   5213 O  O     . GLN A 1 639 ? 127.329 139.554 154.906 1.00 64.88  ? 629 GLN A O     1 
ATOM   5214 C  CB    . GLN A 1 639 ? 126.342 138.580 151.927 1.00 67.08  ? 629 GLN A CB    1 
ATOM   5215 C  CG    . GLN A 1 639 ? 126.621 139.500 150.751 1.00 71.60  ? 629 GLN A CG    1 
ATOM   5216 C  CD    . GLN A 1 639 ? 125.759 139.181 149.549 1.00 77.52  ? 629 GLN A CD    1 
ATOM   5217 O  OE1   . GLN A 1 639 ? 124.887 138.314 149.611 1.00 79.58  ? 629 GLN A OE1   1 
ATOM   5218 N  NE2   . GLN A 1 639 ? 125.998 139.880 148.445 1.00 77.33  ? 629 GLN A NE2   1 
ATOM   5219 N  N     . ILE A 1 640 ? 128.453 140.553 153.231 1.00 65.94  ? 630 ILE A N     1 
ATOM   5220 C  CA    . ILE A 1 640 ? 128.772 141.763 153.976 1.00 66.35  ? 630 ILE A CA    1 
ATOM   5221 C  C     . ILE A 1 640 ? 127.926 142.891 153.411 1.00 66.12  ? 630 ILE A C     1 
ATOM   5222 O  O     . ILE A 1 640 ? 128.060 143.248 152.234 1.00 65.70  ? 630 ILE A O     1 
ATOM   5223 C  CB    . ILE A 1 640 ? 130.270 142.096 153.893 1.00 66.90  ? 630 ILE A CB    1 
ATOM   5224 C  CG1   . ILE A 1 640 ? 131.097 140.915 154.399 1.00 58.72  ? 630 ILE A CG1   1 
ATOM   5225 C  CG2   . ILE A 1 640 ? 130.587 143.361 154.678 1.00 64.33  ? 630 ILE A CG2   1 
ATOM   5226 C  CD1   . ILE A 1 640 ? 130.755 140.486 155.800 1.00 57.85  ? 630 ILE A CD1   1 
ATOM   5227 N  N     . ALA A 1 641 ? 127.056 143.453 154.245 1.00 67.87  ? 631 ALA A N     1 
ATOM   5228 C  CA    . ALA A 1 641 ? 126.196 144.562 153.853 1.00 71.60  ? 631 ALA A CA    1 
ATOM   5229 C  C     . ALA A 1 641 ? 126.732 145.847 154.470 1.00 77.09  ? 631 ALA A C     1 
ATOM   5230 O  O     . ALA A 1 641 ? 126.832 145.956 155.696 1.00 74.78  ? 631 ALA A O     1 
ATOM   5231 C  CB    . ALA A 1 641 ? 124.751 144.316 154.287 1.00 65.24  ? 631 ALA A CB    1 
ATOM   5232 N  N     . LEU A 1 642 ? 127.070 146.815 153.624 1.00 79.39  ? 632 LEU A N     1 
ATOM   5233 C  CA    . LEU A 1 642 ? 127.588 148.088 154.103 1.00 81.23  ? 632 LEU A CA    1 
ATOM   5234 C  C     . LEU A 1 642 ? 126.464 148.900 154.732 1.00 78.28  ? 632 LEU A C     1 
ATOM   5235 O  O     . LEU A 1 642 ? 125.388 149.051 154.144 1.00 77.30  ? 632 LEU A O     1 
ATOM   5236 C  CB    . LEU A 1 642 ? 128.237 148.867 152.960 1.00 79.19  ? 632 LEU A CB    1 
ATOM   5237 C  CG    . LEU A 1 642 ? 129.308 148.116 152.167 1.00 80.01  ? 632 LEU A CG    1 
ATOM   5238 C  CD1   . LEU A 1 642 ? 129.900 149.006 151.090 1.00 76.07  ? 632 LEU A CD1   1 
ATOM   5239 C  CD2   . LEU A 1 642 ? 130.394 147.590 153.090 1.00 70.58  ? 632 LEU A CD2   1 
ATOM   5240 N  N     . VAL A 1 643 ? 126.717 149.422 155.927 1.00 76.79  ? 633 VAL A N     1 
ATOM   5241 C  CA    . VAL A 1 643 ? 125.709 150.162 156.673 1.00 76.03  ? 633 VAL A CA    1 
ATOM   5242 C  C     . VAL A 1 643 ? 125.856 151.657 156.429 1.00 74.71  ? 633 VAL A C     1 
ATOM   5243 O  O     . VAL A 1 643 ? 125.926 152.104 155.285 1.00 76.74  ? 633 VAL A O     1 
ATOM   5244 C  CB    . VAL A 1 643 ? 125.795 149.843 158.173 1.00 74.02  ? 633 VAL A CB    1 
ATOM   5245 C  CG1   . VAL A 1 643 ? 124.822 150.703 158.956 1.00 67.30  ? 633 VAL A CG1   1 
ATOM   5246 C  CG2   . VAL A 1 643 ? 125.525 148.371 158.412 1.00 68.73  ? 633 VAL A CG2   1 
ATOM   5247 P  P     . C   B 2 3   ? 163.464 118.053 143.842 1.00 74.80  ? -36 C   B P     1 
ATOM   5248 O  OP1   . C   B 2 3   ? 163.868 119.057 142.826 1.00 69.24  ? -36 C   B OP1   1 
ATOM   5249 O  OP2   . C   B 2 3   ? 163.430 116.616 143.474 1.00 60.03  ? -36 C   B OP2   1 
ATOM   5250 O  "O5'" . C   B 2 3   ? 162.012 118.437 144.364 1.00 58.63  ? -36 C   B "O5'" 1 
ATOM   5251 C  "C5'" . C   B 2 3   ? 160.953 117.490 144.306 1.00 57.17  ? -36 C   B "C5'" 1 
ATOM   5252 C  "C4'" . C   B 2 3   ? 159.630 118.097 144.696 1.00 54.78  ? -36 C   B "C4'" 1 
ATOM   5253 O  "O4'" . C   B 2 3   ? 159.561 119.459 144.194 1.00 49.02  ? -36 C   B "O4'" 1 
ATOM   5254 C  "C3'" . C   B 2 3   ? 158.413 117.377 144.130 1.00 62.72  ? -36 C   B "C3'" 1 
ATOM   5255 O  "O3'" . C   B 2 3   ? 157.323 117.495 145.043 1.00 71.14  ? -36 C   B "O3'" 1 
ATOM   5256 C  "C2'" . C   B 2 3   ? 158.116 118.178 142.868 1.00 53.95  ? -36 C   B "C2'" 1 
ATOM   5257 O  "O2'" . C   B 2 3   ? 156.788 118.076 142.405 1.00 49.14  ? -36 C   B "O2'" 1 
ATOM   5258 C  "C1'" . C   B 2 3   ? 158.457 119.592 143.321 1.00 46.25  ? -36 C   B "C1'" 1 
ATOM   5259 N  N1    . C   B 2 3   ? 158.854 120.491 142.230 1.00 42.98  ? -36 C   B N1    1 
ATOM   5260 C  C2    . C   B 2 3   ? 158.050 121.584 141.918 1.00 44.19  ? -36 C   B C2    1 
ATOM   5261 O  O2    . C   B 2 3   ? 157.009 121.771 142.558 1.00 45.90  ? -36 C   B O2    1 
ATOM   5262 N  N3    . C   B 2 3   ? 158.424 122.412 140.923 1.00 43.95  ? -36 C   B N3    1 
ATOM   5263 C  C4    . C   B 2 3   ? 159.545 122.185 140.250 1.00 44.88  ? -36 C   B C4    1 
ATOM   5264 N  N4    . C   B 2 3   ? 159.865 123.031 139.273 1.00 39.91  ? -36 C   B N4    1 
ATOM   5265 C  C5    . C   B 2 3   ? 160.386 121.080 140.547 1.00 47.57  ? -36 C   B C5    1 
ATOM   5266 C  C6    . C   B 2 3   ? 160.006 120.268 141.535 1.00 46.58  ? -36 C   B C6    1 
ATOM   5267 P  P     . U   B 2 4   ? 156.953 116.273 146.018 1.00 76.72  ? -35 U   B P     1 
ATOM   5268 O  OP1   . U   B 2 4   ? 158.208 115.821 146.665 1.00 65.85  ? -35 U   B OP1   1 
ATOM   5269 O  OP2   . U   B 2 4   ? 156.125 115.299 145.267 1.00 70.06  ? -35 U   B OP2   1 
ATOM   5270 O  "O5'" . U   B 2 4   ? 156.030 116.937 147.132 1.00 72.69  ? -35 U   B "O5'" 1 
ATOM   5271 C  "C5'" . U   B 2 4   ? 156.565 117.878 148.049 1.00 71.70  ? -35 U   B "C5'" 1 
ATOM   5272 C  "C4'" . U   B 2 4   ? 155.648 118.092 149.223 1.00 73.80  ? -35 U   B "C4'" 1 
ATOM   5273 O  "O4'" . U   B 2 4   ? 155.080 116.818 149.622 1.00 77.26  ? -35 U   B "O4'" 1 
ATOM   5274 C  "C3'" . U   B 2 4   ? 156.312 118.624 150.487 1.00 74.97  ? -35 U   B "C3'" 1 
ATOM   5275 O  "O3'" . U   B 2 4   ? 156.442 120.035 150.498 1.00 72.34  ? -35 U   B "O3'" 1 
ATOM   5276 C  "C2'" . U   B 2 4   ? 155.407 118.095 151.590 1.00 80.22  ? -35 U   B "C2'" 1 
ATOM   5277 O  "O2'" . U   B 2 4   ? 154.236 118.891 151.699 1.00 77.38  ? -35 U   B "O2'" 1 
ATOM   5278 C  "C1'" . U   B 2 4   ? 155.011 116.733 151.027 1.00 83.99  ? -35 U   B "C1'" 1 
ATOM   5279 N  N1    . U   B 2 4   ? 155.923 115.651 151.464 1.00 89.06  ? -35 U   B N1    1 
ATOM   5280 C  C2    . U   B 2 4   ? 155.905 115.242 152.784 1.00 94.71  ? -35 U   B C2    1 
ATOM   5281 O  O2    . U   B 2 4   ? 155.180 115.736 153.631 1.00 97.53  ? -35 U   B O2    1 
ATOM   5282 N  N3    . U   B 2 4   ? 156.781 114.227 153.085 1.00 98.34  ? -35 U   B N3    1 
ATOM   5283 C  C4    . U   B 2 4   ? 157.649 113.589 152.223 1.00 97.71  ? -35 U   B C4    1 
ATOM   5284 O  O4    . U   B 2 4   ? 158.376 112.691 152.646 1.00 99.98  ? -35 U   B O4    1 
ATOM   5285 C  C5    . U   B 2 4   ? 157.602 114.063 150.876 1.00 89.23  ? -35 U   B C5    1 
ATOM   5286 C  C6    . U   B 2 4   ? 156.760 115.048 150.556 1.00 86.36  ? -35 U   B C6    1 
ATOM   5287 P  P     . U   B 2 5   ? 157.773 120.731 149.933 1.00 69.57  ? -34 U   B P     1 
ATOM   5288 O  OP1   . U   B 2 5   ? 158.899 119.781 150.092 1.00 66.18  ? -34 U   B OP1   1 
ATOM   5289 O  OP2   . U   B 2 5   ? 157.874 122.098 150.498 1.00 51.81  ? -34 U   B OP2   1 
ATOM   5290 O  "O5'" . U   B 2 5   ? 157.480 120.882 148.380 1.00 59.51  ? -34 U   B "O5'" 1 
ATOM   5291 C  "C5'" . U   B 2 5   ? 158.390 121.552 147.527 1.00 53.67  ? -34 U   B "C5'" 1 
ATOM   5292 C  "C4'" . U   B 2 5   ? 157.654 122.359 146.495 1.00 47.91  ? -34 U   B "C4'" 1 
ATOM   5293 O  "O4'" . U   B 2 5   ? 156.598 121.555 145.921 1.00 47.76  ? -34 U   B "O4'" 1 
ATOM   5294 C  "C3'" . U   B 2 5   ? 156.939 123.590 147.017 1.00 44.98  ? -34 U   B "C3'" 1 
ATOM   5295 O  "O3'" . U   B 2 5   ? 157.816 124.693 147.146 1.00 44.71  ? -34 U   B "O3'" 1 
ATOM   5296 C  "C2'" . U   B 2 5   ? 155.832 123.808 145.990 1.00 41.06  ? -34 U   B "C2'" 1 
ATOM   5297 O  "O2'" . U   B 2 5   ? 156.329 124.512 144.864 1.00 36.45  ? -34 U   B "O2'" 1 
ATOM   5298 C  "C1'" . U   B 2 5   ? 155.509 122.374 145.562 1.00 47.06  ? -34 U   B "C1'" 1 
ATOM   5299 N  N1    . U   B 2 5   ? 154.276 121.829 146.174 1.00 47.76  ? -34 U   B N1    1 
ATOM   5300 C  C2    . U   B 2 5   ? 153.063 122.170 145.616 1.00 41.30  ? -34 U   B C2    1 
ATOM   5301 O  O2    . U   B 2 5   ? 152.956 122.912 144.667 1.00 45.29  ? -34 U   B O2    1 
ATOM   5302 N  N3    . U   B 2 5   ? 151.963 121.619 146.211 1.00 43.22  ? -34 U   B N3    1 
ATOM   5303 C  C4    . U   B 2 5   ? 151.946 120.764 147.288 1.00 53.47  ? -34 U   B C4    1 
ATOM   5304 O  O4    . U   B 2 5   ? 150.871 120.350 147.714 1.00 46.92  ? -34 U   B O4    1 
ATOM   5305 C  C5    . U   B 2 5   ? 153.240 120.449 147.806 1.00 62.67  ? -34 U   B C5    1 
ATOM   5306 C  C6    . U   B 2 5   ? 154.334 120.974 147.242 1.00 55.57  ? -34 U   B C6    1 
ATOM   5307 P  P     . G   B 2 6   ? 157.613 125.762 148.320 1.00 36.25  ? -33 G   B P     1 
ATOM   5308 O  OP1   . G   B 2 6   ? 158.945 126.127 148.841 1.00 38.99  ? -33 G   B OP1   1 
ATOM   5309 O  OP2   . G   B 2 6   ? 156.576 125.236 149.231 1.00 43.75  ? -33 G   B OP2   1 
ATOM   5310 O  "O5'" . G   B 2 6   ? 157.006 127.031 147.583 1.00 34.11  ? -33 G   B "O5'" 1 
ATOM   5311 C  "C5'" . G   B 2 6   ? 157.594 127.545 146.400 1.00 28.36  ? -33 G   B "C5'" 1 
ATOM   5312 C  "C4'" . G   B 2 6   ? 156.906 128.810 145.965 1.00 27.05  ? -33 G   B "C4'" 1 
ATOM   5313 O  "O4'" . G   B 2 6   ? 155.594 128.502 145.439 1.00 30.99  ? -33 G   B "O4'" 1 
ATOM   5314 C  "C3'" . G   B 2 6   ? 156.632 129.818 147.065 1.00 28.27  ? -33 G   B "C3'" 1 
ATOM   5315 O  "O3'" . G   B 2 6   ? 157.766 130.607 147.356 1.00 24.83  ? -33 G   B "O3'" 1 
ATOM   5316 C  "C2'" . G   B 2 6   ? 155.459 130.622 146.512 1.00 27.04  ? -33 G   B "C2'" 1 
ATOM   5317 O  "O2'" . G   B 2 6   ? 155.920 131.612 145.605 1.00 29.42  ? -33 G   B "O2'" 1 
ATOM   5318 C  "C1'" . G   B 2 6   ? 154.706 129.566 145.706 1.00 19.75  ? -33 G   B "C1'" 1 
ATOM   5319 N  N9    . G   B 2 6   ? 153.492 129.032 146.352 1.00 15.43  ? -33 G   B N9    1 
ATOM   5320 C  C8    . G   B 2 6   ? 153.294 127.711 146.633 1.00 20.24  ? -33 G   B C8    1 
ATOM   5321 N  N7    . G   B 2 6   ? 152.132 127.458 147.151 1.00 19.87  ? -33 G   B N7    1 
ATOM   5322 C  C5    . G   B 2 6   ? 151.505 128.687 147.196 1.00 16.68  ? -33 G   B C5    1 
ATOM   5323 C  C6    . G   B 2 6   ? 150.214 129.021 147.665 1.00 16.64  ? -33 G   B C6    1 
ATOM   5324 O  O6    . G   B 2 6   ? 149.361 128.271 148.138 1.00 21.60  ? -33 G   B O6    1 
ATOM   5325 N  N1    . G   B 2 6   ? 149.951 130.372 147.540 1.00 12.61  ? -33 G   B N1    1 
ATOM   5326 C  C2    . G   B 2 6   ? 150.828 131.284 147.028 1.00 12.25  ? -33 G   B C2    1 
ATOM   5327 N  N2    . G   B 2 6   ? 150.400 132.547 146.992 1.00 11.44  ? -33 G   B N2    1 
ATOM   5328 N  N3    . G   B 2 6   ? 152.039 130.987 146.586 1.00 13.20  ? -33 G   B N3    1 
ATOM   5329 C  C4    . G   B 2 6   ? 152.319 129.672 146.693 1.00 15.00  ? -33 G   B C4    1 
ATOM   5330 P  P     . U   B 2 7   ? 158.124 130.988 148.869 1.00 36.92  ? -32 U   B P     1 
ATOM   5331 O  OP1   . U   B 2 7   ? 159.514 131.493 148.897 1.00 46.84  ? -32 U   B OP1   1 
ATOM   5332 O  OP2   . U   B 2 7   ? 157.718 129.865 149.738 1.00 37.93  ? -32 U   B OP2   1 
ATOM   5333 O  "O5'" . U   B 2 7   ? 157.180 132.224 149.176 1.00 29.76  ? -32 U   B "O5'" 1 
ATOM   5334 C  "C5'" . U   B 2 7   ? 157.271 133.412 148.409 1.00 25.72  ? -32 U   B "C5'" 1 
ATOM   5335 C  "C4'" . U   B 2 7   ? 156.138 134.349 148.727 1.00 24.89  ? -32 U   B "C4'" 1 
ATOM   5336 O  "O4'" . U   B 2 7   ? 154.893 133.791 148.250 1.00 21.44  ? -32 U   B "O4'" 1 
ATOM   5337 C  "C3'" . U   B 2 7   ? 155.885 134.599 150.200 1.00 23.34  ? -32 U   B "C3'" 1 
ATOM   5338 O  "O3'" . U   B 2 7   ? 156.763 135.566 150.742 1.00 27.16  ? -32 U   B "O3'" 1 
ATOM   5339 C  "C2'" . U   B 2 7   ? 154.420 135.017 150.226 1.00 21.50  ? -32 U   B "C2'" 1 
ATOM   5340 O  "O2'" . U   B 2 7   ? 154.281 136.380 149.856 1.00 23.69  ? -32 U   B "O2'" 1 
ATOM   5341 C  "C1'" . U   B 2 7   ? 153.838 134.167 149.103 1.00 14.88  ? -32 U   B "C1'" 1 
ATOM   5342 N  N1    . U   B 2 7   ? 153.155 132.945 149.568 1.00 12.34  ? -32 U   B N1    1 
ATOM   5343 C  C2    . U   B 2 7   ? 151.883 133.066 150.078 1.00 14.55  ? -32 U   B C2    1 
ATOM   5344 O  O2    . U   B 2 7   ? 151.326 134.139 150.193 1.00 15.79  ? -32 U   B O2    1 
ATOM   5345 N  N3    . U   B 2 7   ? 151.299 131.885 150.455 1.00 13.20  ? -32 U   B N3    1 
ATOM   5346 C  C4    . U   B 2 7   ? 151.850 130.632 150.362 1.00 11.35  ? -32 U   B C4    1 
ATOM   5347 O  O4    . U   B 2 7   ? 151.216 129.655 150.740 1.00 10.42  ? -32 U   B O4    1 
ATOM   5348 C  C5    . U   B 2 7   ? 153.162 130.595 149.813 1.00 12.40  ? -32 U   B C5    1 
ATOM   5349 C  C6    . U   B 2 7   ? 153.752 131.724 149.432 1.00 12.55  ? -32 U   B C6    1 
ATOM   5350 P  P     . U   B 2 8   ? 157.209 135.479 152.276 1.00 33.38  ? -31 U   B P     1 
ATOM   5351 O  OP1   . U   B 2 8   ? 158.173 136.575 152.513 1.00 37.30  ? -31 U   B OP1   1 
ATOM   5352 O  OP2   . U   B 2 8   ? 157.588 134.081 152.575 1.00 31.81  ? -31 U   B OP2   1 
ATOM   5353 O  "O5'" . U   B 2 8   ? 155.879 135.815 153.080 1.00 28.62  ? -31 U   B "O5'" 1 
ATOM   5354 C  "C5'" . U   B 2 8   ? 155.280 137.096 152.982 1.00 25.32  ? -31 U   B "C5'" 1 
ATOM   5355 C  "C4'" . U   B 2 8   ? 153.967 137.158 153.716 1.00 22.76  ? -31 U   B "C4'" 1 
ATOM   5356 O  "O4'" . U   B 2 8   ? 152.967 136.382 153.010 1.00 17.98  ? -31 U   B "O4'" 1 
ATOM   5357 C  "C3'" . U   B 2 8   ? 153.949 136.575 155.116 1.00 23.93  ? -31 U   B "C3'" 1 
ATOM   5358 O  "O3'" . U   B 2 8   ? 154.524 137.426 156.092 1.00 31.31  ? -31 U   B "O3'" 1 
ATOM   5359 C  "C2'" . U   B 2 8   ? 152.469 136.293 155.329 1.00 20.38  ? -31 U   B "C2'" 1 
ATOM   5360 O  "O2'" . U   B 2 8   ? 151.767 137.489 155.625 1.00 27.67  ? -31 U   B "O2'" 1 
ATOM   5361 C  "C1'" . U   B 2 8   ? 152.054 135.828 153.933 1.00 17.49  ? -31 U   B "C1'" 1 
ATOM   5362 N  N1    . U   B 2 8   ? 152.094 134.356 153.821 1.00 17.31  ? -31 U   B N1    1 
ATOM   5363 C  C2    . U   B 2 8   ? 150.975 133.667 154.218 1.00 13.20  ? -31 U   B C2    1 
ATOM   5364 O  O2    . U   B 2 8   ? 149.971 134.213 154.628 1.00 12.33  ? -31 U   B O2    1 
ATOM   5365 N  N3    . U   B 2 8   ? 151.059 132.313 154.115 1.00 9.22   ? -31 U   B N3    1 
ATOM   5366 C  C4    . U   B 2 8   ? 152.137 131.590 153.668 1.00 12.31  ? -31 U   B C4    1 
ATOM   5367 O  O4    . U   B 2 8   ? 152.071 130.367 153.629 1.00 12.87  ? -31 U   B O4    1 
ATOM   5368 C  C5    . U   B 2 8   ? 153.263 132.371 153.285 1.00 13.77  ? -31 U   B C5    1 
ATOM   5369 C  C6    . U   B 2 8   ? 153.206 133.696 153.373 1.00 14.90  ? -31 U   B C6    1 
ATOM   5370 P  P     . G   B 2 9   ? 155.202 136.798 157.404 1.00 28.71  ? -30 G   B P     1 
ATOM   5371 O  OP1   . G   B 2 9   ? 156.004 137.846 158.069 1.00 32.78  ? -30 G   B OP1   1 
ATOM   5372 O  OP2   . G   B 2 9   ? 155.864 135.541 156.995 1.00 23.43  ? -30 G   B OP2   1 
ATOM   5373 O  "O5'" . G   B 2 9   ? 153.968 136.442 158.346 1.00 30.80  ? -30 G   B "O5'" 1 
ATOM   5374 C  "C5'" . G   B 2 9   ? 153.106 137.458 158.833 1.00 23.60  ? -30 G   B "C5'" 1 
ATOM   5375 C  "C4'" . G   B 2 9   ? 151.858 136.888 159.457 1.00 17.95  ? -30 G   B "C4'" 1 
ATOM   5376 O  "O4'" . G   B 2 9   ? 151.083 136.175 158.463 1.00 23.84  ? -30 G   B "O4'" 1 
ATOM   5377 C  "C3'" . G   B 2 9   ? 152.060 135.864 160.557 1.00 18.14  ? -30 G   B "C3'" 1 
ATOM   5378 O  "O3'" . G   B 2 9   ? 152.379 136.450 161.802 1.00 25.47  ? -30 G   B "O3'" 1 
ATOM   5379 C  "C2'" . G   B 2 9   ? 150.734 135.118 160.562 1.00 19.07  ? -30 G   B "C2'" 1 
ATOM   5380 O  "O2'" . G   B 2 9   ? 149.746 135.856 161.260 1.00 27.30  ? -30 G   B "O2'" 1 
ATOM   5381 C  "C1'" . G   B 2 9   ? 150.375 135.118 159.076 1.00 21.39  ? -30 G   B "C1'" 1 
ATOM   5382 N  N9    . G   B 2 9   ? 150.729 133.846 158.418 1.00 16.09  ? -30 G   B N9    1 
ATOM   5383 C  C8    . G   B 2 9   ? 151.791 133.605 157.591 1.00 13.41  ? -30 G   B C8    1 
ATOM   5384 N  N7    . G   B 2 9   ? 151.838 132.378 157.172 1.00 12.97  ? -30 G   B N7    1 
ATOM   5385 C  C5    . G   B 2 9   ? 150.739 131.773 157.752 1.00 11.24  ? -30 G   B C5    1 
ATOM   5386 C  C6    . G   B 2 9   ? 150.274 130.442 157.667 1.00 13.34  ? -30 G   B C6    1 
ATOM   5387 O  O6    . G   B 2 9   ? 150.756 129.515 157.021 1.00 18.15  ? -30 G   B O6    1 
ATOM   5388 N  N1    . G   B 2 9   ? 149.126 130.241 158.410 1.00 12.76  ? -30 G   B N1    1 
ATOM   5389 C  C2    . G   B 2 9   ? 148.505 131.202 159.150 1.00 13.46  ? -30 G   B C2    1 
ATOM   5390 N  N2    . G   B 2 9   ? 147.407 130.825 159.809 1.00 14.91  ? -30 G   B N2    1 
ATOM   5391 N  N3    . G   B 2 9   ? 148.930 132.446 159.245 1.00 15.90  ? -30 G   B N3    1 
ATOM   5392 C  C4    . G   B 2 9   ? 150.045 132.662 158.525 1.00 13.97  ? -30 G   B C4    1 
ATOM   5393 P  P     . U   B 2 10  ? 153.628 135.912 162.649 1.00 27.59  ? -29 U   B P     1 
ATOM   5394 O  OP1   . U   B 2 10  ? 154.041 136.979 163.583 1.00 28.47  ? -29 U   B OP1   1 
ATOM   5395 O  OP2   . U   B 2 10  ? 154.623 135.358 161.705 1.00 26.15  ? -29 U   B OP2   1 
ATOM   5396 O  "O5'" . U   B 2 10  ? 153.023 134.717 163.500 1.00 21.15  ? -29 U   B "O5'" 1 
ATOM   5397 C  "C5'" . U   B 2 10  ? 152.020 134.957 164.471 1.00 20.23  ? -29 U   B "C5'" 1 
ATOM   5398 C  "C4'" . U   B 2 10  ? 151.131 133.757 164.660 1.00 20.31  ? -29 U   B "C4'" 1 
ATOM   5399 O  "O4'" . U   B 2 10  ? 150.609 133.323 163.380 1.00 28.33  ? -29 U   B "O4'" 1 
ATOM   5400 C  "C3'" . U   B 2 10  ? 151.786 132.510 165.224 1.00 21.13  ? -29 U   B "C3'" 1 
ATOM   5401 O  "O3'" . U   B 2 10  ? 151.943 132.562 166.632 1.00 32.04  ? -29 U   B "O3'" 1 
ATOM   5402 C  "C2'" . U   B 2 10  ? 150.834 131.413 164.770 1.00 21.25  ? -29 U   B "C2'" 1 
ATOM   5403 O  "O2'" . U   B 2 10  ? 149.697 131.357 165.616 1.00 29.06  ? -29 U   B "O2'" 1 
ATOM   5404 C  "C1'" . U   B 2 10  ? 150.394 131.931 163.398 1.00 21.47  ? -29 U   B "C1'" 1 
ATOM   5405 N  N1    . U   B 2 10  ? 151.161 131.301 162.302 1.00 16.31  ? -29 U   B N1    1 
ATOM   5406 C  C2    . U   B 2 10  ? 150.850 129.994 162.000 1.00 20.58  ? -29 U   B C2    1 
ATOM   5407 O  O2    . U   B 2 10  ? 149.983 129.359 162.570 1.00 25.16  ? -29 U   B O2    1 
ATOM   5408 N  N3    . U   B 2 10  ? 151.587 129.431 161.002 1.00 19.99  ? -29 U   B N3    1 
ATOM   5409 C  C4    . U   B 2 10  ? 152.590 130.028 160.285 1.00 18.89  ? -29 U   B C4    1 
ATOM   5410 O  O4    . U   B 2 10  ? 153.157 129.382 159.409 1.00 23.70  ? -29 U   B O4    1 
ATOM   5411 C  C5    . U   B 2 10  ? 152.859 131.381 160.648 1.00 15.11  ? -29 U   B C5    1 
ATOM   5412 C  C6    . U   B 2 10  ? 152.152 131.958 161.621 1.00 16.97  ? -29 U   B C6    1 
ATOM   5413 P  P     . A   B 2 11  ? 153.397 132.524 167.319 1.00 34.23  ? -28 A   B P     1 
ATOM   5414 O  OP1   . A   B 2 11  ? 153.187 132.753 168.763 1.00 34.31  ? -28 A   B OP1   1 
ATOM   5415 O  OP2   . A   B 2 11  ? 154.330 133.405 166.587 1.00 22.10  ? -28 A   B OP2   1 
ATOM   5416 O  "O5'" . A   B 2 11  ? 153.871 131.016 167.155 1.00 26.70  ? -28 A   B "O5'" 1 
ATOM   5417 C  "C5'" . A   B 2 11  ? 153.058 129.943 167.619 1.00 28.93  ? -28 A   B "C5'" 1 
ATOM   5418 C  "C4'" . A   B 2 11  ? 153.836 128.943 168.441 1.00 34.36  ? -28 A   B "C4'" 1 
ATOM   5419 O  "O4'" . A   B 2 11  ? 154.974 128.459 167.679 1.00 37.43  ? -28 A   B "O4'" 1 
ATOM   5420 C  "C3'" . A   B 2 11  ? 154.399 129.457 169.762 1.00 33.94  ? -28 A   B "C3'" 1 
ATOM   5421 O  "O3'" . A   B 2 11  ? 154.378 128.393 170.709 1.00 36.38  ? -28 A   B "O3'" 1 
ATOM   5422 C  "C2'" . A   B 2 11  ? 155.846 129.775 169.404 1.00 29.92  ? -28 A   B "C2'" 1 
ATOM   5423 O  "O2'" . A   B 2 11  ? 156.736 129.771 170.497 1.00 42.14  ? -28 A   B "O2'" 1 
ATOM   5424 C  "C1'" . A   B 2 11  ? 156.161 128.658 168.421 1.00 33.25  ? -28 A   B "C1'" 1 
ATOM   5425 N  N9    . A   B 2 11  ? 157.238 128.960 167.478 1.00 41.84  ? -28 A   B N9    1 
ATOM   5426 C  C8    . A   B 2 11  ? 157.514 130.144 166.846 1.00 41.95  ? -28 A   B C8    1 
ATOM   5427 N  N7    . A   B 2 11  ? 158.545 130.086 166.042 1.00 36.96  ? -28 A   B N7    1 
ATOM   5428 C  C5    . A   B 2 11  ? 158.971 128.774 166.157 1.00 39.27  ? -28 A   B C5    1 
ATOM   5429 C  C6    . A   B 2 11  ? 160.021 128.074 165.559 1.00 43.49  ? -28 A   B C6    1 
ATOM   5430 N  N6    . A   B 2 11  ? 160.861 128.627 164.691 1.00 48.89  ? -28 A   B N6    1 
ATOM   5431 N  N1    . A   B 2 11  ? 160.179 126.776 165.883 1.00 48.87  ? -28 A   B N1    1 
ATOM   5432 C  C2    . A   B 2 11  ? 159.329 126.224 166.754 1.00 46.79  ? -28 A   B C2    1 
ATOM   5433 N  N3    . A   B 2 11  ? 158.300 126.778 167.383 1.00 41.34  ? -28 A   B N3    1 
ATOM   5434 C  C4    . A   B 2 11  ? 158.177 128.068 167.035 1.00 42.23  ? -28 A   B C4    1 
ATOM   5435 P  P     . U   B 2 12  ? 153.646 128.572 172.125 1.00 47.54  ? -27 U   B P     1 
ATOM   5436 O  OP1   . U   B 2 12  ? 153.454 127.227 172.709 1.00 50.25  ? -27 U   B OP1   1 
ATOM   5437 O  OP2   . U   B 2 12  ? 152.472 129.454 171.957 1.00 41.20  ? -27 U   B OP2   1 
ATOM   5438 O  "O5'" . U   B 2 12  ? 154.731 129.326 173.007 1.00 41.55  ? -27 U   B "O5'" 1 
ATOM   5439 C  "C5'" . U   B 2 12  ? 154.386 130.476 173.753 1.00 35.00  ? -27 U   B "C5'" 1 
ATOM   5440 C  "C4'" . U   B 2 12  ? 155.359 131.598 173.511 1.00 33.97  ? -27 U   B "C4'" 1 
ATOM   5441 O  "O4'" . U   B 2 12  ? 154.764 132.843 173.943 1.00 34.24  ? -27 U   B "O4'" 1 
ATOM   5442 C  "C3'" . U   B 2 12  ? 156.671 131.513 174.274 1.00 36.65  ? -27 U   B "C3'" 1 
ATOM   5443 O  "O3'" . U   B 2 12  ? 157.620 130.690 173.608 1.00 43.98  ? -27 U   B "O3'" 1 
ATOM   5444 C  "C2'" . U   B 2 12  ? 157.090 132.974 174.403 1.00 36.97  ? -27 U   B "C2'" 1 
ATOM   5445 O  "O2'" . U   B 2 12  ? 157.722 133.423 173.216 1.00 42.25  ? -27 U   B "O2'" 1 
ATOM   5446 C  "C1'" . U   B 2 12  ? 155.738 133.679 174.519 1.00 30.92  ? -27 U   B "C1'" 1 
ATOM   5447 N  N1    . U   B 2 12  ? 155.330 133.956 175.916 1.00 30.27  ? -27 U   B N1    1 
ATOM   5448 C  C2    . U   B 2 12  ? 155.612 135.195 176.449 1.00 27.11  ? -27 U   B C2    1 
ATOM   5449 O  O2    . U   B 2 12  ? 156.196 136.054 175.835 1.00 25.81  ? -27 U   B O2    1 
ATOM   5450 N  N3    . U   B 2 12  ? 155.186 135.390 177.733 1.00 29.49  ? -27 U   B N3    1 
ATOM   5451 C  C4    . U   B 2 12  ? 154.508 134.486 178.518 1.00 29.44  ? -27 U   B C4    1 
ATOM   5452 O  O4    . U   B 2 12  ? 154.186 134.797 179.661 1.00 31.52  ? -27 U   B O4    1 
ATOM   5453 C  C5    . U   B 2 12  ? 154.241 133.230 177.897 1.00 24.53  ? -27 U   B C5    1 
ATOM   5454 C  C6    . U   B 2 12  ? 154.644 133.016 176.646 1.00 28.65  ? -27 U   B C6    1 
ATOM   5455 P  P     . A   B 2 13  ? 159.170 130.677 174.038 1.00 52.88  ? -26 A   B P     1 
ATOM   5456 O  OP1   . A   B 2 13  ? 159.244 130.725 175.515 1.00 53.43  ? -26 A   B OP1   1 
ATOM   5457 O  OP2   . A   B 2 13  ? 159.881 131.689 173.224 1.00 46.42  ? -26 A   B OP2   1 
ATOM   5458 O  "O5'" . A   B 2 13  ? 159.695 129.248 173.569 1.00 54.32  ? -26 A   B "O5'" 1 
ATOM   5459 C  "C5'" . A   B 2 13  ? 159.091 128.055 174.054 1.00 57.54  ? -26 A   B "C5'" 1 
ATOM   5460 C  "C4'" . A   B 2 13  ? 159.649 126.818 173.388 1.00 57.20  ? -26 A   B "C4'" 1 
ATOM   5461 O  "O4'" . A   B 2 13  ? 159.320 126.816 171.978 1.00 49.46  ? -26 A   B "O4'" 1 
ATOM   5462 C  "C3'" . A   B 2 13  ? 161.160 126.657 173.413 1.00 55.50  ? -26 A   B "C3'" 1 
ATOM   5463 O  "O3'" . A   B 2 13  ? 161.635 126.144 174.645 1.00 60.29  ? -26 A   B "O3'" 1 
ATOM   5464 C  "C2'" . A   B 2 13  ? 161.418 125.725 172.237 1.00 48.97  ? -26 A   B "C2'" 1 
ATOM   5465 O  "O2'" . A   B 2 13  ? 161.171 124.378 172.607 1.00 42.81  ? -26 A   B "O2'" 1 
ATOM   5466 C  "C1'" . A   B 2 13  ? 160.332 126.153 171.252 1.00 49.13  ? -26 A   B "C1'" 1 
ATOM   5467 N  N9    . A   B 2 13  ? 160.821 127.036 170.173 1.00 48.21  ? -26 A   B N9    1 
ATOM   5468 C  C8    . A   B 2 13  ? 160.295 128.244 169.808 1.00 45.71  ? -26 A   B C8    1 
ATOM   5469 N  N7    . A   B 2 13  ? 160.900 128.809 168.799 1.00 44.77  ? -26 A   B N7    1 
ATOM   5470 C  C5    . A   B 2 13  ? 161.887 127.903 168.459 1.00 50.13  ? -26 A   B C5    1 
ATOM   5471 C  C6    . A   B 2 13  ? 162.869 127.924 167.457 1.00 52.95  ? -26 A   B C6    1 
ATOM   5472 N  N6    . A   B 2 13  ? 163.020 128.926 166.594 1.00 49.74  ? -26 A   B N6    1 
ATOM   5473 N  N1    . A   B 2 13  ? 163.706 126.874 167.372 1.00 57.83  ? -26 A   B N1    1 
ATOM   5474 C  C2    . A   B 2 13  ? 163.554 125.870 168.242 1.00 58.74  ? -26 A   B C2    1 
ATOM   5475 N  N3    . A   B 2 13  ? 162.671 125.741 169.230 1.00 53.96  ? -26 A   B N3    1 
ATOM   5476 C  C4    . A   B 2 13  ? 161.850 126.802 169.287 1.00 51.29  ? -26 A   B C4    1 
ATOM   5477 P  P     . U   B 2 14  ? 163.089 126.557 175.185 1.00 75.23  ? -25 U   B P     1 
ATOM   5478 O  OP1   . U   B 2 14  ? 163.281 125.897 176.499 1.00 71.49  ? -25 U   B OP1   1 
ATOM   5479 O  OP2   . U   B 2 14  ? 163.228 128.029 175.073 1.00 65.31  ? -25 U   B OP2   1 
ATOM   5480 O  "O5'" . U   B 2 14  ? 164.098 125.890 174.149 1.00 68.05  ? -25 U   B "O5'" 1 
ATOM   5481 C  "C5'" . U   B 2 14  ? 164.517 124.541 174.297 1.00 62.98  ? -25 U   B "C5'" 1 
ATOM   5482 C  "C4'" . U   B 2 14  ? 165.798 124.275 173.549 1.00 63.28  ? -25 U   B "C4'" 1 
ATOM   5483 O  "O4'" . U   B 2 14  ? 165.562 124.347 172.121 1.00 61.13  ? -25 U   B "O4'" 1 
ATOM   5484 C  "C3'" . U   B 2 14  ? 166.926 125.267 173.784 1.00 66.73  ? -25 U   B "C3'" 1 
ATOM   5485 O  "O3'" . U   B 2 14  ? 167.637 125.021 174.984 1.00 71.86  ? -25 U   B "O3'" 1 
ATOM   5486 C  "C2'" . U   B 2 14  ? 167.777 125.112 172.529 1.00 66.39  ? -25 U   B "C2'" 1 
ATOM   5487 O  "O2'" . U   B 2 14  ? 168.614 123.971 172.626 1.00 63.66  ? -25 U   B "O2'" 1 
ATOM   5488 C  "C1'" . U   B 2 14  ? 166.712 124.841 171.467 1.00 67.72  ? -25 U   B "C1'" 1 
ATOM   5489 N  N1    . U   B 2 14  ? 166.347 126.056 170.705 1.00 69.45  ? -25 U   B N1    1 
ATOM   5490 C  C2    . U   B 2 14  ? 167.130 126.388 169.618 1.00 67.73  ? -25 U   B C2    1 
ATOM   5491 O  O2    . U   B 2 14  ? 168.096 125.732 169.279 1.00 73.08  ? -25 U   B O2    1 
ATOM   5492 N  N3    . U   B 2 14  ? 166.750 127.518 168.943 1.00 60.56  ? -25 U   B N3    1 
ATOM   5493 C  C4    . U   B 2 14  ? 165.680 128.329 169.245 1.00 62.16  ? -25 U   B C4    1 
ATOM   5494 O  O4    . U   B 2 14  ? 165.451 129.318 168.553 1.00 67.81  ? -25 U   B O4    1 
ATOM   5495 C  C5    . U   B 2 14  ? 164.919 127.921 170.385 1.00 59.41  ? -25 U   B C5    1 
ATOM   5496 C  C6    . U   B 2 14  ? 165.264 126.822 171.057 1.00 62.48  ? -25 U   B C6    1 
ATOM   5497 P  P     . A   B 2 15  ? 168.311 126.237 175.786 1.00 75.69  ? -24 A   B P     1 
ATOM   5498 O  OP1   . A   B 2 15  ? 168.916 125.694 177.026 1.00 66.42  ? -24 A   B OP1   1 
ATOM   5499 O  OP2   . A   B 2 15  ? 167.315 127.329 175.887 1.00 75.54  ? -24 A   B OP2   1 
ATOM   5500 O  "O5'" . A   B 2 15  ? 169.496 126.714 174.836 1.00 80.35  ? -24 A   B "O5'" 1 
ATOM   5501 C  "C5'" . A   B 2 15  ? 170.632 125.888 174.626 1.00 77.51  ? -24 A   B "C5'" 1 
ATOM   5502 C  "C4'" . A   B 2 15  ? 171.575 126.478 173.608 1.00 77.81  ? -24 A   B "C4'" 1 
ATOM   5503 O  "O4'" . A   B 2 15  ? 170.952 126.496 172.304 1.00 74.26  ? -24 A   B "O4'" 1 
ATOM   5504 C  "C3'" . A   B 2 15  ? 172.003 127.919 173.837 1.00 80.41  ? -24 A   B "C3'" 1 
ATOM   5505 O  "O3'" . A   B 2 15  ? 173.067 128.009 174.770 1.00 83.80  ? -24 A   B "O3'" 1 
ATOM   5506 C  "C2'" . A   B 2 15  ? 172.394 128.386 172.438 1.00 78.44  ? -24 A   B "C2'" 1 
ATOM   5507 O  "O2'" . A   B 2 15  ? 173.725 127.995 172.137 1.00 78.98  ? -24 A   B "O2'" 1 
ATOM   5508 C  "C1'" . A   B 2 15  ? 171.451 127.575 171.549 1.00 72.59  ? -24 A   B "C1'" 1 
ATOM   5509 N  N9    . A   B 2 15  ? 170.322 128.347 170.995 1.00 68.61  ? -24 A   B N9    1 
ATOM   5510 C  C8    . A   B 2 15  ? 169.008 128.287 171.373 1.00 64.75  ? -24 A   B C8    1 
ATOM   5511 N  N7    . A   B 2 15  ? 168.223 129.063 170.676 1.00 62.46  ? -24 A   B N7    1 
ATOM   5512 C  C5    . A   B 2 15  ? 169.071 129.667 169.763 1.00 64.86  ? -24 A   B C5    1 
ATOM   5513 C  C6    . A   B 2 15  ? 168.847 130.604 168.739 1.00 60.55  ? -24 A   B C6    1 
ATOM   5514 N  N6    . A   B 2 15  ? 167.650 131.116 168.447 1.00 55.60  ? -24 A   B N6    1 
ATOM   5515 N  N1    . A   B 2 15  ? 169.906 131.007 168.009 1.00 58.32  ? -24 A   B N1    1 
ATOM   5516 C  C2    . A   B 2 15  ? 171.106 130.497 168.298 1.00 61.80  ? -24 A   B C2    1 
ATOM   5517 N  N3    . A   B 2 15  ? 171.442 129.613 169.234 1.00 67.16  ? -24 A   B N3    1 
ATOM   5518 C  C4    . A   B 2 15  ? 170.366 129.230 169.942 1.00 67.66  ? -24 A   B C4    1 
ATOM   5519 P  P     . U   B 2 16  ? 173.339 129.362 175.594 1.00 99.80  ? -23 U   B P     1 
ATOM   5520 O  OP1   . U   B 2 16  ? 174.549 129.144 176.423 1.00 93.74  ? -23 U   B OP1   1 
ATOM   5521 O  OP2   . U   B 2 16  ? 172.076 129.786 176.245 1.00 95.13  ? -23 U   B OP2   1 
ATOM   5522 O  "O5'" . U   B 2 16  ? 173.722 130.430 174.478 1.00 92.13  ? -23 U   B "O5'" 1 
ATOM   5523 C  "C5'" . U   B 2 16  ? 174.964 130.359 173.793 1.00 89.32  ? -23 U   B "C5'" 1 
ATOM   5524 C  "C4'" . U   B 2 16  ? 175.082 131.462 172.773 1.00 85.19  ? -23 U   B "C4'" 1 
ATOM   5525 O  "O4'" . U   B 2 16  ? 174.100 131.254 171.728 1.00 78.45  ? -23 U   B "O4'" 1 
ATOM   5526 C  "C3'" . U   B 2 16  ? 174.800 132.867 173.287 1.00 83.01  ? -23 U   B "C3'" 1 
ATOM   5527 O  "O3'" . U   B 2 16  ? 175.939 133.475 173.883 1.00 95.19  ? -23 U   B "O3'" 1 
ATOM   5528 C  "C2'" . U   B 2 16  ? 174.327 133.603 172.037 1.00 75.50  ? -23 U   B "C2'" 1 
ATOM   5529 O  "O2'" . U   B 2 16  ? 175.434 134.058 171.273 1.00 79.44  ? -23 U   B "O2'" 1 
ATOM   5530 C  "C1'" . U   B 2 16  ? 173.624 132.493 171.253 1.00 74.49  ? -23 U   B "C1'" 1 
ATOM   5531 N  N1    . U   B 2 16  ? 172.150 132.529 171.390 1.00 65.03  ? -23 U   B N1    1 
ATOM   5532 C  C2    . U   B 2 16  ? 171.441 133.280 170.476 1.00 58.62  ? -23 U   B C2    1 
ATOM   5533 O  O2    . U   B 2 16  ? 171.974 133.911 169.581 1.00 58.29  ? -23 U   B O2    1 
ATOM   5534 N  N3    . U   B 2 16  ? 170.081 133.269 170.645 1.00 55.31  ? -23 U   B N3    1 
ATOM   5535 C  C4    . U   B 2 16  ? 169.374 132.597 171.615 1.00 57.25  ? -23 U   B C4    1 
ATOM   5536 O  O4    . U   B 2 16  ? 168.148 132.682 171.643 1.00 61.42  ? -23 U   B O4    1 
ATOM   5537 C  C5    . U   B 2 16  ? 170.177 131.842 172.519 1.00 60.54  ? -23 U   B C5    1 
ATOM   5538 C  C6    . U   B 2 16  ? 171.502 131.834 172.377 1.00 64.76  ? -23 U   B C6    1 
ATOM   5539 P  P     . U   B 2 17  ? 176.454 133.045 175.346 1.00 105.14 ? -22 U   B P     1 
ATOM   5540 O  OP1   . U   B 2 17  ? 177.278 131.818 175.215 1.00 90.32  ? -22 U   B OP1   1 
ATOM   5541 O  OP2   . U   B 2 17  ? 175.304 133.082 176.284 1.00 99.32  ? -22 U   B OP2   1 
ATOM   5542 O  "O5'" . U   B 2 17  ? 177.466 134.202 175.756 1.00 99.30  ? -22 U   B "O5'" 1 
ATOM   5543 C  "C5'" . U   B 2 17  ? 176.993 135.454 176.234 1.00 95.16  ? -22 U   B "C5'" 1 
ATOM   5544 C  "C4'" . U   B 2 17  ? 177.527 136.600 175.411 1.00 95.02  ? -22 U   B "C4'" 1 
ATOM   5545 O  "O4'" . U   B 2 17  ? 178.847 136.977 175.887 1.00 95.24  ? -22 U   B "O4'" 1 
ATOM   5546 C  "C3'" . U   B 2 17  ? 177.671 136.321 173.915 1.00 96.05  ? -22 U   B "C3'" 1 
ATOM   5547 O  "O3'" . U   B 2 17  ? 177.311 137.486 173.181 1.00 90.36  ? -22 U   B "O3'" 1 
ATOM   5548 C  "C2'" . U   B 2 17  ? 179.165 136.053 173.757 1.00 98.30  ? -22 U   B "C2'" 1 
ATOM   5549 O  "O2'" . U   B 2 17  ? 179.673 136.322 172.468 1.00 91.43  ? -22 U   B "O2'" 1 
ATOM   5550 C  "C1'" . U   B 2 17  ? 179.758 136.986 174.806 1.00 100.76 ? -22 U   B "C1'" 1 
ATOM   5551 N  N1    . U   B 2 17  ? 181.070 136.558 175.312 1.00 103.43 ? -22 U   B N1    1 
ATOM   5552 C  C2    . U   B 2 17  ? 182.072 137.504 175.377 1.00 104.22 ? -22 U   B C2    1 
ATOM   5553 O  O2    . U   B 2 17  ? 181.908 138.664 175.040 1.00 103.80 ? -22 U   B O2    1 
ATOM   5554 N  N3    . U   B 2 17  ? 183.272 137.041 175.858 1.00 103.47 ? -22 U   B N3    1 
ATOM   5555 C  C4    . U   B 2 17  ? 183.564 135.756 176.266 1.00 98.71  ? -22 U   B C4    1 
ATOM   5556 O  O4    . U   B 2 17  ? 184.696 135.491 176.676 1.00 94.01  ? -22 U   B O4    1 
ATOM   5557 C  C5    . U   B 2 17  ? 182.475 134.838 176.164 1.00 99.01  ? -22 U   B C5    1 
ATOM   5558 C  C6    . U   B 2 17  ? 181.294 135.259 175.701 1.00 100.16 ? -22 U   B C6    1 
ATOM   5559 P  P     . C   B 2 18  ? 175.779 137.709 172.765 1.00 83.73  ? -21 C   B P     1 
ATOM   5560 O  OP1   . C   B 2 18  ? 174.992 137.967 173.996 1.00 80.73  ? -21 C   B OP1   1 
ATOM   5561 O  OP2   . C   B 2 18  ? 175.408 136.597 171.860 1.00 80.97  ? -21 C   B OP2   1 
ATOM   5562 O  "O5'" . C   B 2 18  ? 175.802 139.037 171.896 1.00 75.23  ? -21 C   B "O5'" 1 
ATOM   5563 C  "C5'" . C   B 2 18  ? 176.589 139.115 170.719 1.00 74.22  ? -21 C   B "C5'" 1 
ATOM   5564 C  "C4'" . C   B 2 18  ? 175.749 139.516 169.537 1.00 71.39  ? -21 C   B "C4'" 1 
ATOM   5565 O  "O4'" . C   B 2 18  ? 174.896 138.413 169.142 1.00 64.58  ? -21 C   B "O4'" 1 
ATOM   5566 C  "C3'" . C   B 2 18  ? 174.780 140.657 169.789 1.00 69.72  ? -21 C   B "C3'" 1 
ATOM   5567 O  "O3'" . C   B 2 18  ? 175.407 141.925 169.713 1.00 72.72  ? -21 C   B "O3'" 1 
ATOM   5568 C  "C2'" . C   B 2 18  ? 173.714 140.435 168.726 1.00 65.76  ? -21 C   B "C2'" 1 
ATOM   5569 O  "O2'" . C   B 2 18  ? 174.155 140.935 167.473 1.00 64.58  ? -21 C   B "O2'" 1 
ATOM   5570 C  "C1'" . C   B 2 18  ? 173.675 138.908 168.639 1.00 61.13  ? -21 C   B "C1'" 1 
ATOM   5571 N  N1    . C   B 2 18  ? 172.558 138.279 169.384 1.00 54.78  ? -21 C   B N1    1 
ATOM   5572 C  C2    . C   B 2 18  ? 171.237 138.442 168.954 1.00 51.00  ? -21 C   B C2    1 
ATOM   5573 O  O2    . C   B 2 18  ? 171.021 139.157 167.968 1.00 51.02  ? -21 C   B O2    1 
ATOM   5574 N  N3    . C   B 2 18  ? 170.236 137.836 169.628 1.00 49.92  ? -21 C   B N3    1 
ATOM   5575 C  C4    . C   B 2 18  ? 170.513 137.073 170.682 1.00 46.63  ? -21 C   B C4    1 
ATOM   5576 N  N4    . C   B 2 18  ? 169.501 136.488 171.324 1.00 46.39  ? -21 C   B N4    1 
ATOM   5577 C  C5    . C   B 2 18  ? 171.843 136.873 171.132 1.00 49.44  ? -21 C   B C5    1 
ATOM   5578 C  C6    . C   B 2 18  ? 172.821 137.482 170.455 1.00 52.24  ? -21 C   B C6    1 
ATOM   5579 P  P     . U   B 2 19  ? 174.992 143.090 170.733 1.00 73.38  ? -20 U   B P     1 
ATOM   5580 O  OP1   . U   B 2 19  ? 175.962 144.199 170.594 1.00 69.29  ? -20 U   B OP1   1 
ATOM   5581 O  OP2   . U   B 2 19  ? 174.757 142.483 172.064 1.00 68.50  ? -20 U   B OP2   1 
ATOM   5582 O  "O5'" . U   B 2 19  ? 173.597 143.598 170.168 1.00 72.69  ? -20 U   B "O5'" 1 
ATOM   5583 C  "C5'" . U   B 2 19  ? 173.498 144.123 168.854 1.00 65.84  ? -20 U   B "C5'" 1 
ATOM   5584 C  "C4'" . U   B 2 19  ? 172.065 144.380 168.467 1.00 59.94  ? -20 U   B "C4'" 1 
ATOM   5585 O  "O4'" . U   B 2 19  ? 171.350 143.129 168.337 1.00 56.73  ? -20 U   B "O4'" 1 
ATOM   5586 C  "C3'" . U   B 2 19  ? 171.229 145.170 169.458 1.00 58.87  ? -20 U   B "C3'" 1 
ATOM   5587 O  "O3'" . U   B 2 19  ? 171.475 146.565 169.388 1.00 63.22  ? -20 U   B "O3'" 1 
ATOM   5588 C  "C2'" . U   B 2 19  ? 169.809 144.786 169.066 1.00 53.17  ? -20 U   B "C2'" 1 
ATOM   5589 O  "O2'" . U   B 2 19  ? 169.385 145.532 167.937 1.00 52.73  ? -20 U   B "O2'" 1 
ATOM   5590 C  "C1'" . U   B 2 19  ? 169.986 143.329 168.637 1.00 51.39  ? -20 U   B "C1'" 1 
ATOM   5591 N  N1    . U   B 2 19  ? 169.559 142.371 169.680 1.00 43.92  ? -20 U   B N1    1 
ATOM   5592 C  C2    . U   B 2 19  ? 168.213 142.093 169.739 1.00 43.15  ? -20 U   B C2    1 
ATOM   5593 O  O2    . U   B 2 19  ? 167.408 142.601 168.985 1.00 43.98  ? -20 U   B O2    1 
ATOM   5594 N  N3    . U   B 2 19  ? 167.836 141.202 170.705 1.00 42.26  ? -20 U   B N3    1 
ATOM   5595 C  C4    . U   B 2 19  ? 168.666 140.572 171.601 1.00 41.40  ? -20 U   B C4    1 
ATOM   5596 O  O4    . U   B 2 19  ? 168.187 139.791 172.419 1.00 43.71  ? -20 U   B O4    1 
ATOM   5597 C  C5    . U   B 2 19  ? 170.046 140.910 171.477 1.00 44.42  ? -20 U   B C5    1 
ATOM   5598 C  C6    . U   B 2 19  ? 170.442 141.777 170.542 1.00 46.10  ? -20 U   B C6    1 
ATOM   5599 P  P     . U   B 2 20  ? 171.655 147.446 170.722 1.00 65.35  ? -19 U   B P     1 
ATOM   5600 O  OP1   . U   B 2 20  ? 172.156 148.774 170.297 1.00 55.29  ? -19 U   B OP1   1 
ATOM   5601 O  OP2   . U   B 2 20  ? 172.435 146.668 171.712 1.00 57.55  ? -19 U   B OP2   1 
ATOM   5602 O  "O5'" . U   B 2 20  ? 170.169 147.641 171.264 1.00 64.30  ? -19 U   B "O5'" 1 
ATOM   5603 C  "C5'" . U   B 2 20  ? 169.100 147.875 170.353 1.00 55.66  ? -19 U   B "C5'" 1 
ATOM   5604 C  "C4'" . U   B 2 20  ? 167.894 148.505 171.002 1.00 51.27  ? -19 U   B "C4'" 1 
ATOM   5605 O  "O4'" . U   B 2 20  ? 167.286 147.575 171.935 1.00 47.30  ? -19 U   B "O4'" 1 
ATOM   5606 C  "C3'" . U   B 2 20  ? 168.146 149.798 171.775 1.00 50.39  ? -19 U   B "C3'" 1 
ATOM   5607 O  "O3'" . U   B 2 20  ? 167.112 150.734 171.478 1.00 49.94  ? -19 U   B "O3'" 1 
ATOM   5608 C  "C2'" . U   B 2 20  ? 168.053 149.359 173.235 1.00 47.12  ? -19 U   B "C2'" 1 
ATOM   5609 O  "O2'" . U   B 2 20  ? 167.635 150.373 174.123 1.00 51.65  ? -19 U   B "O2'" 1 
ATOM   5610 C  "C1'" . U   B 2 20  ? 167.036 148.228 173.159 1.00 46.97  ? -19 U   B "C1'" 1 
ATOM   5611 N  N1    . U   B 2 20  ? 167.151 147.241 174.243 1.00 46.37  ? -19 U   B N1    1 
ATOM   5612 C  C2    . U   B 2 20  ? 165.987 146.721 174.764 1.00 44.27  ? -19 U   B C2    1 
ATOM   5613 O  O2    . U   B 2 20  ? 164.887 147.034 174.354 1.00 43.25  ? -19 U   B O2    1 
ATOM   5614 N  N3    . U   B 2 20  ? 166.150 145.814 175.775 1.00 38.10  ? -19 U   B N3    1 
ATOM   5615 C  C4    . U   B 2 20  ? 167.340 145.384 176.311 1.00 36.60  ? -19 U   B C4    1 
ATOM   5616 O  O4    . U   B 2 20  ? 167.329 144.558 177.220 1.00 39.38  ? -19 U   B O4    1 
ATOM   5617 C  C5    . U   B 2 20  ? 168.502 145.971 175.726 1.00 37.34  ? -19 U   B C5    1 
ATOM   5618 C  C6    . U   B 2 20  ? 168.372 146.860 174.738 1.00 39.94  ? -19 U   B C6    1 
ATOM   5619 P  P     . U   B 2 21  ? 167.325 151.798 170.294 1.00 59.54  ? -18 U   B P     1 
ATOM   5620 O  OP1   . U   B 2 21  ? 168.754 152.184 170.293 1.00 55.69  ? -18 U   B OP1   1 
ATOM   5621 O  OP2   . U   B 2 21  ? 166.276 152.836 170.405 1.00 48.77  ? -18 U   B OP2   1 
ATOM   5622 O  "O5'" . U   B 2 21  ? 167.071 150.967 168.959 1.00 44.66  ? -18 U   B "O5'" 1 
ATOM   5623 C  "C5'" . U   B 2 21  ? 165.756 150.783 168.449 1.00 40.21  ? -18 U   B "C5'" 1 
ATOM   5624 C  "C4'" . U   B 2 21  ? 165.752 150.016 167.149 1.00 40.10  ? -18 U   B "C4'" 1 
ATOM   5625 O  "O4'" . U   B 2 21  ? 166.295 150.845 166.086 1.00 46.76  ? -18 U   B "O4'" 1 
ATOM   5626 C  "C3'" . U   B 2 21  ? 166.572 148.727 167.135 1.00 49.89  ? -18 U   B "C3'" 1 
ATOM   5627 O  "O3'" . U   B 2 21  ? 165.931 147.784 166.282 1.00 48.07  ? -18 U   B "O3'" 1 
ATOM   5628 C  "C2'" . U   B 2 21  ? 167.871 149.172 166.481 1.00 52.25  ? -18 U   B "C2'" 1 
ATOM   5629 O  "O2'" . U   B 2 21  ? 168.620 148.134 165.889 1.00 57.10  ? -18 U   B "O2'" 1 
ATOM   5630 C  "C1'" . U   B 2 21  ? 167.348 150.155 165.447 1.00 46.51  ? -18 U   B "C1'" 1 
ATOM   5631 N  N1    . U   B 2 21  ? 168.340 151.128 164.979 1.00 49.49  ? -18 U   B N1    1 
ATOM   5632 C  C2    . U   B 2 21  ? 168.625 151.098 163.637 1.00 49.72  ? -18 U   B C2    1 
ATOM   5633 O  O2    . U   B 2 21  ? 168.086 150.316 162.881 1.00 52.13  ? -18 U   B O2    1 
ATOM   5634 N  N3    . U   B 2 21  ? 169.553 152.012 163.215 1.00 50.63  ? -18 U   B N3    1 
ATOM   5635 C  C4    . U   B 2 21  ? 170.211 152.931 164.002 1.00 57.31  ? -18 U   B C4    1 
ATOM   5636 O  O4    . U   B 2 21  ? 171.027 153.692 163.486 1.00 61.94  ? -18 U   B O4    1 
ATOM   5637 C  C5    . U   B 2 21  ? 169.858 152.893 165.389 1.00 53.55  ? -18 U   B C5    1 
ATOM   5638 C  C6    . U   B 2 21  ? 168.955 152.013 165.824 1.00 51.02  ? -18 U   B C6    1 
ATOM   5639 P  P     . U   B 2 22  ? 165.789 146.253 166.729 1.00 46.82  ? -17 U   B P     1 
ATOM   5640 O  OP1   . U   B 2 22  ? 166.267 146.113 168.123 1.00 42.85  ? -17 U   B OP1   1 
ATOM   5641 O  OP2   . U   B 2 22  ? 166.357 145.413 165.654 1.00 36.79  ? -17 U   B OP2   1 
ATOM   5642 O  "O5'" . U   B 2 22  ? 164.221 146.019 166.757 1.00 45.25  ? -17 U   B "O5'" 1 
ATOM   5643 C  "C5'" . U   B 2 22  ? 163.374 146.899 167.481 1.00 35.85  ? -17 U   B "C5'" 1 
ATOM   5644 C  "C4'" . U   B 2 22  ? 162.016 146.294 167.702 1.00 30.36  ? -17 U   B "C4'" 1 
ATOM   5645 O  "O4'" . U   B 2 22  ? 161.459 145.925 166.415 1.00 30.23  ? -17 U   B "O4'" 1 
ATOM   5646 C  "C3'" . U   B 2 22  ? 162.004 145.030 168.557 1.00 28.62  ? -17 U   B "C3'" 1 
ATOM   5647 O  "O3'" . U   B 2 22  ? 160.832 145.007 169.368 1.00 32.42  ? -17 U   B "O3'" 1 
ATOM   5648 C  "C2'" . U   B 2 22  ? 161.942 143.912 167.521 1.00 29.58  ? -17 U   B "C2'" 1 
ATOM   5649 O  "O2'" . U   B 2 22  ? 161.337 142.725 167.981 1.00 34.09  ? -17 U   B "O2'" 1 
ATOM   5650 C  "C1'" . U   B 2 22  ? 161.125 144.553 166.408 1.00 25.93  ? -17 U   B "C1'" 1 
ATOM   5651 N  N1    . U   B 2 22  ? 161.432 144.026 165.073 1.00 32.09  ? -17 U   B N1    1 
ATOM   5652 C  C2    . U   B 2 22  ? 160.595 143.072 164.535 1.00 33.73  ? -17 U   B C2    1 
ATOM   5653 O  O2    . U   B 2 22  ? 159.619 142.639 165.115 1.00 39.02  ? -17 U   B O2    1 
ATOM   5654 N  N3    . U   B 2 22  ? 160.951 142.630 163.289 1.00 32.60  ? -17 U   B N3    1 
ATOM   5655 C  C4    . U   B 2 22  ? 162.029 143.040 162.544 1.00 33.55  ? -17 U   B C4    1 
ATOM   5656 O  O4    . U   B 2 22  ? 162.213 142.546 161.436 1.00 36.37  ? -17 U   B O4    1 
ATOM   5657 C  C5    . U   B 2 22  ? 162.844 144.030 163.167 1.00 33.47  ? -17 U   B C5    1 
ATOM   5658 C  C6    . U   B 2 22  ? 162.525 144.479 164.380 1.00 36.25  ? -17 U   B C6    1 
ATOM   5659 P  P     . A   B 2 23  ? 160.863 145.639 170.841 1.00 40.01  ? -16 A   B P     1 
ATOM   5660 O  OP1   . A   B 2 23  ? 159.470 145.920 171.248 1.00 35.00  ? -16 A   B OP1   1 
ATOM   5661 O  OP2   . A   B 2 23  ? 161.869 146.723 170.861 1.00 39.09  ? -16 A   B OP2   1 
ATOM   5662 O  "O5'" . A   B 2 23  ? 161.421 144.470 171.762 1.00 37.60  ? -16 A   B "O5'" 1 
ATOM   5663 C  "C5'" . A   B 2 23  ? 160.577 143.416 172.202 1.00 32.43  ? -16 A   B "C5'" 1 
ATOM   5664 C  "C4'" . A   B 2 23  ? 161.226 142.594 173.288 1.00 36.22  ? -16 A   B "C4'" 1 
ATOM   5665 O  "O4'" . A   B 2 23  ? 162.611 142.336 172.934 1.00 42.30  ? -16 A   B "O4'" 1 
ATOM   5666 C  "C3'" . A   B 2 23  ? 161.253 143.234 174.671 1.00 36.42  ? -16 A   B "C3'" 1 
ATOM   5667 O  "O3'" . A   B 2 23  ? 161.112 142.218 175.659 1.00 45.54  ? -16 A   B "O3'" 1 
ATOM   5668 C  "C2'" . A   B 2 23  ? 162.660 143.809 174.747 1.00 36.64  ? -16 A   B "C2'" 1 
ATOM   5669 O  "O2'" . A   B 2 23  ? 163.151 143.974 176.059 1.00 49.06  ? -16 A   B "O2'" 1 
ATOM   5670 C  "C1'" . A   B 2 23  ? 163.457 142.768 173.975 1.00 31.30  ? -16 A   B "C1'" 1 
ATOM   5671 N  N9    . A   B 2 23  ? 164.685 143.293 173.379 1.00 33.97  ? -16 A   B N9    1 
ATOM   5672 C  C8    . A   B 2 23  ? 164.793 144.168 172.333 1.00 37.35  ? -16 A   B C8    1 
ATOM   5673 N  N7    . A   B 2 23  ? 166.025 144.470 172.019 1.00 39.72  ? -16 A   B N7    1 
ATOM   5674 C  C5    . A   B 2 23  ? 166.782 143.740 172.920 1.00 39.24  ? -16 A   B C5    1 
ATOM   5675 C  C6    . A   B 2 23  ? 168.163 143.624 173.111 1.00 37.14  ? -16 A   B C6    1 
ATOM   5676 N  N6    . A   B 2 23  ? 169.065 144.268 172.375 1.00 42.01  ? -16 A   B N6    1 
ATOM   5677 N  N1    . A   B 2 23  ? 168.595 142.816 174.096 1.00 29.81  ? -16 A   B N1    1 
ATOM   5678 C  C2    . A   B 2 23  ? 167.689 142.173 174.835 1.00 31.14  ? -16 A   B C2    1 
ATOM   5679 N  N3    . A   B 2 23  ? 166.363 142.198 174.755 1.00 36.79  ? -16 A   B N3    1 
ATOM   5680 C  C4    . A   B 2 23  ? 165.969 143.008 173.762 1.00 38.50  ? -16 A   B C4    1 
ATOM   5681 P  P     . U   B 2 24  ? 159.656 141.805 176.183 1.00 48.31  ? -15 U   B P     1 
ATOM   5682 O  OP1   . U   B 2 24  ? 158.771 142.981 176.030 1.00 41.13  ? -15 U   B OP1   1 
ATOM   5683 O  OP2   . U   B 2 24  ? 159.803 141.149 177.501 1.00 34.26  ? -15 U   B OP2   1 
ATOM   5684 O  "O5'" . U   B 2 24  ? 159.172 140.712 175.139 1.00 41.98  ? -15 U   B "O5'" 1 
ATOM   5685 C  "C5'" . U   B 2 24  ? 159.335 139.326 175.404 1.00 36.11  ? -15 U   B "C5'" 1 
ATOM   5686 C  "C4'" . U   B 2 24  ? 158.023 138.588 175.341 1.00 31.61  ? -15 U   B "C4'" 1 
ATOM   5687 O  "O4'" . U   B 2 24  ? 157.230 138.909 176.514 1.00 32.70  ? -15 U   B "O4'" 1 
ATOM   5688 C  "C3'" . U   B 2 24  ? 157.146 138.901 174.131 1.00 25.59  ? -15 U   B "C3'" 1 
ATOM   5689 O  "O3'" . U   B 2 24  ? 156.488 137.711 173.701 1.00 27.74  ? -15 U   B "O3'" 1 
ATOM   5690 C  "C2'" . U   B 2 24  ? 156.119 139.878 174.694 1.00 28.60  ? -15 U   B "C2'" 1 
ATOM   5691 O  "O2'" . U   B 2 24  ? 154.886 139.895 174.010 1.00 32.04  ? -15 U   B "O2'" 1 
ATOM   5692 C  "C1'" . U   B 2 24  ? 155.955 139.373 176.121 1.00 27.65  ? -15 U   B "C1'" 1 
ATOM   5693 N  N1    . U   B 2 24  ? 155.539 140.417 177.067 1.00 29.39  ? -15 U   B N1    1 
ATOM   5694 C  C2    . U   B 2 24  ? 154.625 140.096 178.046 1.00 30.07  ? -15 U   B C2    1 
ATOM   5695 O  O2    . U   B 2 24  ? 154.154 138.982 178.175 1.00 30.71  ? -15 U   B O2    1 
ATOM   5696 N  N3    . U   B 2 24  ? 154.294 141.130 178.884 1.00 30.26  ? -15 U   B N3    1 
ATOM   5697 C  C4    . U   B 2 24  ? 154.769 142.424 178.836 1.00 31.12  ? -15 U   B C4    1 
ATOM   5698 O  O4    . U   B 2 24  ? 154.376 143.250 179.659 1.00 32.95  ? -15 U   B O4    1 
ATOM   5699 C  C5    . U   B 2 24  ? 155.701 142.674 177.788 1.00 26.25  ? -15 U   B C5    1 
ATOM   5700 C  C6    . U   B 2 24  ? 156.041 141.688 176.963 1.00 25.82  ? -15 U   B C6    1 
ATOM   5701 P  P     . A   B 2 25  ? 157.026 136.905 172.422 1.00 27.02  ? -14 A   B P     1 
ATOM   5702 O  OP1   . A   B 2 25  ? 155.864 136.379 171.673 1.00 26.55  ? -14 A   B OP1   1 
ATOM   5703 O  OP2   . A   B 2 25  ? 158.102 135.987 172.855 1.00 28.92  ? -14 A   B OP2   1 
ATOM   5704 O  "O5'" . A   B 2 25  ? 157.700 138.026 171.527 1.00 29.61  ? -14 A   B "O5'" 1 
ATOM   5705 C  "C5'" . A   B 2 25  ? 156.924 138.819 170.650 1.00 27.11  ? -14 A   B "C5'" 1 
ATOM   5706 C  "C4'" . A   B 2 25  ? 157.805 139.606 169.725 1.00 25.27  ? -14 A   B "C4'" 1 
ATOM   5707 O  "O4'" . A   B 2 25  ? 158.731 140.407 170.500 1.00 29.81  ? -14 A   B "O4'" 1 
ATOM   5708 C  "C3'" . A   B 2 25  ? 158.702 138.786 168.822 1.00 29.06  ? -14 A   B "C3'" 1 
ATOM   5709 O  "O3'" . A   B 2 25  ? 158.018 138.276 167.692 1.00 36.49  ? -14 A   B "O3'" 1 
ATOM   5710 C  "C2'" . A   B 2 25  ? 159.815 139.768 168.488 1.00 31.42  ? -14 A   B "C2'" 1 
ATOM   5711 O  "O2'" . A   B 2 25  ? 159.389 140.689 167.496 1.00 28.75  ? -14 A   B "O2'" 1 
ATOM   5712 C  "C1'" . A   B 2 25  ? 159.957 140.521 169.811 1.00 31.62  ? -14 A   B "C1'" 1 
ATOM   5713 N  N9    . A   B 2 25  ? 161.041 139.981 170.657 1.00 29.99  ? -14 A   B N9    1 
ATOM   5714 C  C8    . A   B 2 25  ? 160.961 139.053 171.660 1.00 28.26  ? -14 A   B C8    1 
ATOM   5715 N  N7    . A   B 2 25  ? 162.110 138.786 172.226 1.00 30.88  ? -14 A   B N7    1 
ATOM   5716 C  C5    . A   B 2 25  ? 163.015 139.595 171.553 1.00 32.08  ? -14 A   B C5    1 
ATOM   5717 C  C6    . A   B 2 25  ? 164.406 139.788 171.674 1.00 34.64  ? -14 A   B C6    1 
ATOM   5718 N  N6    . A   B 2 25  ? 165.185 139.157 172.550 1.00 32.64  ? -14 A   B N6    1 
ATOM   5719 N  N1    . A   B 2 25  ? 164.996 140.668 170.849 1.00 36.16  ? -14 A   B N1    1 
ATOM   5720 C  C2    . A   B 2 25  ? 164.231 141.307 169.966 1.00 33.44  ? -14 A   B C2    1 
ATOM   5721 N  N3    . A   B 2 25  ? 162.926 141.215 169.754 1.00 31.85  ? -14 A   B N3    1 
ATOM   5722 C  C4    . A   B 2 25  ? 162.366 140.332 170.588 1.00 31.35  ? -14 A   B C4    1 
ATOM   5723 P  P     . G   B 2 26  ? 158.738 137.254 166.687 1.00 39.76  ? -13 G   B P     1 
ATOM   5724 O  OP1   . G   B 2 26  ? 157.681 136.535 165.945 1.00 29.78  ? -13 G   B OP1   1 
ATOM   5725 O  OP2   . G   B 2 26  ? 159.736 136.475 167.446 1.00 36.86  ? -13 G   B OP2   1 
ATOM   5726 O  "O5'" . G   B 2 26  ? 159.490 138.206 165.657 1.00 39.77  ? -13 G   B "O5'" 1 
ATOM   5727 C  "C5'" . G   B 2 26  ? 160.660 137.783 164.976 1.00 40.55  ? -13 G   B "C5'" 1 
ATOM   5728 C  "C4'" . G   B 2 26  ? 161.652 138.909 164.851 1.00 38.97  ? -13 G   B "C4'" 1 
ATOM   5729 O  "O4'" . G   B 2 26  ? 161.924 139.446 166.169 1.00 44.50  ? -13 G   B "O4'" 1 
ATOM   5730 C  "C3'" . G   B 2 26  ? 163.019 138.527 164.313 1.00 38.47  ? -13 G   B "C3'" 1 
ATOM   5731 O  "O3'" . G   B 2 26  ? 163.061 138.478 162.899 1.00 43.39  ? -13 G   B "O3'" 1 
ATOM   5732 C  "C2'" . G   B 2 26  ? 163.928 139.591 164.913 1.00 39.40  ? -13 G   B "C2'" 1 
ATOM   5733 O  "O2'" . G   B 2 26  ? 163.841 140.800 164.177 1.00 41.76  ? -13 G   B "O2'" 1 
ATOM   5734 C  "C1'" . G   B 2 26  ? 163.280 139.812 166.276 1.00 35.37  ? -13 G   B "C1'" 1 
ATOM   5735 N  N9    . G   B 2 26  ? 163.891 138.995 167.340 1.00 34.00  ? -13 G   B N9    1 
ATOM   5736 C  C8    . G   B 2 26  ? 163.218 138.147 168.177 1.00 33.48  ? -13 G   B C8    1 
ATOM   5737 N  N7    . G   B 2 26  ? 163.995 137.550 169.035 1.00 41.24  ? -13 G   B N7    1 
ATOM   5738 C  C5    . G   B 2 26  ? 165.259 138.045 168.757 1.00 36.85  ? -13 G   B C5    1 
ATOM   5739 C  C6    . G   B 2 26  ? 166.507 137.761 169.360 1.00 35.41  ? -13 G   B C6    1 
ATOM   5740 O  O6    . G   B 2 26  ? 166.745 136.998 170.300 1.00 41.51  ? -13 G   B O6    1 
ATOM   5741 N  N1    . G   B 2 26  ? 167.539 138.476 168.769 1.00 37.75  ? -13 G   B N1    1 
ATOM   5742 C  C2    . G   B 2 26  ? 167.380 139.349 167.729 1.00 38.24  ? -13 G   B C2    1 
ATOM   5743 N  N2    . G   B 2 26  ? 168.482 139.952 167.278 1.00 43.93  ? -13 G   B N2    1 
ATOM   5744 N  N3    . G   B 2 26  ? 166.226 139.620 167.158 1.00 38.61  ? -13 G   B N3    1 
ATOM   5745 C  C4    . G   B 2 26  ? 165.211 138.938 167.714 1.00 39.48  ? -13 G   B C4    1 
ATOM   5746 P  P     . G   B 2 27  ? 163.659 137.189 162.153 1.00 59.51  ? -12 G   B P     1 
ATOM   5747 O  OP1   . G   B 2 27  ? 163.191 137.209 160.748 1.00 53.23  ? -12 G   B OP1   1 
ATOM   5748 O  OP2   . G   B 2 27  ? 163.402 136.003 163.007 1.00 57.70  ? -12 G   B OP2   1 
ATOM   5749 O  "O5'" . G   B 2 27  ? 165.228 137.436 162.148 1.00 49.38  ? -12 G   B "O5'" 1 
ATOM   5750 C  "C5'" . G   B 2 27  ? 165.773 138.658 161.684 1.00 49.35  ? -12 G   B "C5'" 1 
ATOM   5751 C  "C4'" . G   B 2 27  ? 167.234 138.772 162.035 1.00 49.29  ? -12 G   B "C4'" 1 
ATOM   5752 O  "O4'" . G   B 2 27  ? 167.383 138.970 163.460 1.00 47.23  ? -12 G   B "O4'" 1 
ATOM   5753 C  "C3'" . G   B 2 27  ? 168.089 137.551 161.740 1.00 50.24  ? -12 G   B "C3'" 1 
ATOM   5754 O  "O3'" . G   B 2 27  ? 168.492 137.491 160.384 1.00 60.70  ? -12 G   B "O3'" 1 
ATOM   5755 C  "C2'" . G   B 2 27  ? 169.256 137.714 162.706 1.00 49.70  ? -12 G   B "C2'" 1 
ATOM   5756 O  "O2'" . G   B 2 27  ? 170.212 138.624 162.183 1.00 53.14  ? -12 G   B "O2'" 1 
ATOM   5757 C  "C1'" . G   B 2 27  ? 168.579 138.371 163.907 1.00 44.15  ? -12 G   B "C1'" 1 
ATOM   5758 N  N9    . G   B 2 27  ? 168.264 137.428 164.994 1.00 41.16  ? -12 G   B N9    1 
ATOM   5759 C  C8    . G   B 2 27  ? 167.015 137.079 165.436 1.00 42.45  ? -12 G   B C8    1 
ATOM   5760 N  N7    . G   B 2 27  ? 167.038 136.245 166.434 1.00 43.71  ? -12 G   B N7    1 
ATOM   5761 C  C5    . G   B 2 27  ? 168.385 136.041 166.674 1.00 43.13  ? -12 G   B C5    1 
ATOM   5762 C  C6    . G   B 2 27  ? 169.025 135.227 167.635 1.00 46.28  ? -12 G   B C6    1 
ATOM   5763 O  O6    . G   B 2 27  ? 168.515 134.511 168.500 1.00 48.74  ? -12 G   B O6    1 
ATOM   5764 N  N1    . G   B 2 27  ? 170.405 135.307 167.533 1.00 46.03  ? -12 G   B N1    1 
ATOM   5765 C  C2    . G   B 2 27  ? 171.080 136.066 166.619 1.00 46.70  ? -12 G   B C2    1 
ATOM   5766 N  N2    . G   B 2 27  ? 172.414 136.003 166.681 1.00 47.04  ? -12 G   B N2    1 
ATOM   5767 N  N3    . G   B 2 27  ? 170.497 136.828 165.714 1.00 46.59  ? -12 G   B N3    1 
ATOM   5768 C  C4    . G   B 2 27  ? 169.156 136.768 165.798 1.00 42.41  ? -12 G   B C4    1 
ATOM   5769 P  P     . U   B 2 28  ? 168.584 136.085 159.619 1.00 67.81  ? -11 U   B P     1 
ATOM   5770 O  OP1   . U   B 2 28  ? 168.900 136.374 158.200 1.00 59.08  ? -11 U   B OP1   1 
ATOM   5771 O  OP2   . U   B 2 28  ? 167.380 135.290 159.956 1.00 57.07  ? -11 U   B OP2   1 
ATOM   5772 O  "O5'" . U   B 2 28  ? 169.838 135.359 160.280 1.00 69.87  ? -11 U   B "O5'" 1 
ATOM   5773 C  "C5'" . U   B 2 28  ? 171.140 135.927 160.227 1.00 63.08  ? -11 U   B "C5'" 1 
ATOM   5774 C  "C4'" . U   B 2 28  ? 172.094 135.173 161.119 1.00 61.81  ? -11 U   B "C4'" 1 
ATOM   5775 O  "O4'" . U   B 2 28  ? 171.695 135.331 162.502 1.00 61.40  ? -11 U   B "O4'" 1 
ATOM   5776 C  "C3'" . U   B 2 28  ? 172.128 133.670 160.907 1.00 65.25  ? -11 U   B "C3'" 1 
ATOM   5777 O  "O3'" . U   B 2 28  ? 172.974 133.303 159.832 1.00 77.29  ? -11 U   B "O3'" 1 
ATOM   5778 C  "C2'" . U   B 2 28  ? 172.588 133.136 162.261 1.00 64.81  ? -11 U   B "C2'" 1 
ATOM   5779 O  "O2'" . U   B 2 28  ? 174.001 133.207 162.378 1.00 61.24  ? -11 U   B "O2'" 1 
ATOM   5780 C  "C1'" . U   B 2 28  ? 171.975 134.152 163.226 1.00 62.71  ? -11 U   B "C1'" 1 
ATOM   5781 N  N1    . U   B 2 28  ? 170.731 133.678 163.881 1.00 55.44  ? -11 U   B N1    1 
ATOM   5782 C  C2    . U   B 2 28  ? 170.842 132.840 164.972 1.00 53.23  ? -11 U   B C2    1 
ATOM   5783 O  O2    . U   B 2 28  ? 171.906 132.445 165.406 1.00 57.60  ? -11 U   B O2    1 
ATOM   5784 N  N3    . U   B 2 28  ? 169.660 132.462 165.545 1.00 52.87  ? -11 U   B N3    1 
ATOM   5785 C  C4    . U   B 2 28  ? 168.397 132.837 165.152 1.00 50.23  ? -11 U   B C4    1 
ATOM   5786 O  O4    . U   B 2 28  ? 167.418 132.410 165.762 1.00 53.68  ? -11 U   B O4    1 
ATOM   5787 C  C5    . U   B 2 28  ? 168.360 133.709 164.026 1.00 45.38  ? -11 U   B C5    1 
ATOM   5788 C  C6    . U   B 2 28  ? 169.498 134.095 163.450 1.00 51.52  ? -11 U   B C6    1 
ATOM   5789 P  P     . A   B 2 29  ? 172.419 132.393 158.631 1.00 91.19  ? -10 A   B P     1 
ATOM   5790 O  OP1   . A   B 2 29  ? 173.239 132.665 157.426 1.00 87.28  ? -10 A   B OP1   1 
ATOM   5791 O  OP2   . A   B 2 29  ? 170.947 132.550 158.559 1.00 77.40  ? -10 A   B OP2   1 
ATOM   5792 O  "O5'" . A   B 2 29  ? 172.724 130.909 159.111 1.00 78.06  ? -10 A   B "O5'" 1 
ATOM   5793 C  "C5'" . A   B 2 29  ? 171.702 130.103 159.672 1.00 70.92  ? -10 A   B "C5'" 1 
ATOM   5794 C  "C4'" . A   B 2 29  ? 172.268 129.073 160.613 1.00 74.09  ? -10 A   B "C4'" 1 
ATOM   5795 O  "O4'" . A   B 2 29  ? 172.291 129.613 161.958 1.00 71.17  ? -10 A   B "O4'" 1 
ATOM   5796 C  "C3'" . A   B 2 29  ? 171.461 127.790 160.732 1.00 78.43  ? -10 A   B "C3'" 1 
ATOM   5797 O  "O3'" . A   B 2 29  ? 171.779 126.853 159.718 1.00 87.11  ? -10 A   B "O3'" 1 
ATOM   5798 C  "C2'" . A   B 2 29  ? 171.792 127.309 162.136 1.00 78.22  ? -10 A   B "C2'" 1 
ATOM   5799 O  "O2'" . A   B 2 29  ? 173.068 126.688 162.161 1.00 82.94  ? -10 A   B "O2'" 1 
ATOM   5800 C  "C1'" . A   B 2 29  ? 171.891 128.630 162.885 1.00 69.06  ? -10 A   B "C1'" 1 
ATOM   5801 N  N9    . A   B 2 29  ? 170.599 129.062 163.453 1.00 69.91  ? -10 A   B N9    1 
ATOM   5802 C  C8    . A   B 2 29  ? 169.802 130.047 162.934 1.00 66.47  ? -10 A   B C8    1 
ATOM   5803 N  N7    . A   B 2 29  ? 168.714 130.270 163.613 1.00 59.42  ? -10 A   B N7    1 
ATOM   5804 C  C5    . A   B 2 29  ? 168.801 129.379 164.662 1.00 60.12  ? -10 A   B C5    1 
ATOM   5805 C  C6    . A   B 2 29  ? 167.940 129.133 165.736 1.00 59.47  ? -10 A   B C6    1 
ATOM   5806 N  N6    . A   B 2 29  ? 166.799 129.793 165.918 1.00 59.97  ? -10 A   B N6    1 
ATOM   5807 N  N1    . A   B 2 29  ? 168.291 128.181 166.620 1.00 61.91  ? -10 A   B N1    1 
ATOM   5808 C  C2    . A   B 2 29  ? 169.441 127.528 166.422 1.00 65.96  ? -10 A   B C2    1 
ATOM   5809 N  N3    . A   B 2 29  ? 170.337 127.672 165.447 1.00 67.69  ? -10 A   B N3    1 
ATOM   5810 C  C4    . A   B 2 29  ? 169.955 128.628 164.586 1.00 67.56  ? -10 A   B C4    1 
ATOM   5811 P  P     . U   B 2 30  ? 170.705 125.746 159.275 1.00 103.38 ? -9  U   B P     1 
ATOM   5812 O  OP1   . U   B 2 30  ? 171.376 124.802 158.348 1.00 94.70  ? -9  U   B OP1   1 
ATOM   5813 O  OP2   . U   B 2 30  ? 169.471 126.445 158.842 1.00 91.47  ? -9  U   B OP2   1 
ATOM   5814 O  "O5'" . U   B 2 30  ? 170.385 124.968 160.626 1.00 94.78  ? -9  U   B "O5'" 1 
ATOM   5815 C  "C5'" . U   B 2 30  ? 169.271 124.097 160.717 1.00 89.21  ? -9  U   B "C5'" 1 
ATOM   5816 C  "C4'" . U   B 2 30  ? 169.142 123.510 162.097 1.00 87.49  ? -9  U   B "C4'" 1 
ATOM   5817 O  "O4'" . U   B 2 30  ? 169.143 124.574 163.083 1.00 83.62  ? -9  U   B "O4'" 1 
ATOM   5818 C  "C3'" . U   B 2 30  ? 167.853 122.746 162.362 1.00 90.25  ? -9  U   B "C3'" 1 
ATOM   5819 O  "O3'" . U   B 2 30  ? 167.920 121.404 161.911 1.00 98.68  ? -9  U   B "O3'" 1 
ATOM   5820 C  "C2'" . U   B 2 30  ? 167.685 122.872 163.870 1.00 87.32  ? -9  U   B "C2'" 1 
ATOM   5821 O  "O2'" . U   B 2 30  ? 168.507 121.935 164.548 1.00 87.27  ? -9  U   B "O2'" 1 
ATOM   5822 C  "C1'" . U   B 2 30  ? 168.240 124.273 164.125 1.00 82.47  ? -9  U   B "C1'" 1 
ATOM   5823 N  N1    . U   B 2 30  ? 167.196 125.326 164.144 1.00 74.71  ? -9  U   B N1    1 
ATOM   5824 C  C2    . U   B 2 30  ? 166.261 125.385 165.164 1.00 69.85  ? -9  U   B C2    1 
ATOM   5825 O  O2    . U   B 2 30  ? 166.203 124.586 166.080 1.00 71.45  ? -9  U   B O2    1 
ATOM   5826 N  N3    . U   B 2 30  ? 165.367 126.421 165.066 1.00 67.09  ? -9  U   B N3    1 
ATOM   5827 C  C4    . U   B 2 30  ? 165.323 127.389 164.082 1.00 68.87  ? -9  U   B C4    1 
ATOM   5828 O  O4    . U   B 2 30  ? 164.464 128.266 164.116 1.00 66.65  ? -9  U   B O4    1 
ATOM   5829 C  C5    . U   B 2 30  ? 166.322 127.267 163.077 1.00 71.51  ? -9  U   B C5    1 
ATOM   5830 C  C6    . U   B 2 30  ? 167.201 126.271 163.149 1.00 74.43  ? -9  U   B C6    1 
ATOM   5831 P  P     . U   B 2 31  ? 166.694 120.747 161.110 1.00 102.62 ? -8  U   B P     1 
ATOM   5832 O  OP1   . U   B 2 31  ? 167.178 119.481 160.505 1.00 91.18  ? -8  U   B OP1   1 
ATOM   5833 O  OP2   . U   B 2 31  ? 166.093 121.780 160.230 1.00 94.63  ? -8  U   B OP2   1 
ATOM   5834 O  "O5'" . U   B 2 31  ? 165.650 120.377 162.254 1.00 97.67  ? -8  U   B "O5'" 1 
ATOM   5835 C  "C5'" . U   B 2 31  ? 166.031 119.550 163.343 1.00 89.15  ? -8  U   B "C5'" 1 
ATOM   5836 C  "C4'" . U   B 2 31  ? 165.075 119.683 164.501 1.00 88.03  ? -8  U   B "C4'" 1 
ATOM   5837 O  "O4'" . U   B 2 31  ? 165.221 120.990 165.113 1.00 84.35  ? -8  U   B "O4'" 1 
ATOM   5838 C  "C3'" . U   B 2 31  ? 163.599 119.606 164.152 1.00 90.24  ? -8  U   B "C3'" 1 
ATOM   5839 O  "O3'" . U   B 2 31  ? 163.131 118.279 163.986 1.00 92.05  ? -8  U   B "O3'" 1 
ATOM   5840 C  "C2'" . U   B 2 31  ? 162.946 120.349 165.308 1.00 83.33  ? -8  U   B "C2'" 1 
ATOM   5841 O  "O2'" . U   B 2 31  ? 162.883 119.526 166.463 1.00 78.24  ? -8  U   B "O2'" 1 
ATOM   5842 C  "C1'" . U   B 2 31  ? 163.966 121.456 165.562 1.00 81.30  ? -8  U   B "C1'" 1 
ATOM   5843 N  N1    . U   B 2 31  ? 163.634 122.698 164.828 1.00 78.50  ? -8  U   B N1    1 
ATOM   5844 C  C2    . U   B 2 31  ? 162.639 123.507 165.336 1.00 74.92  ? -8  U   B C2    1 
ATOM   5845 O  O2    . U   B 2 31  ? 162.023 123.244 166.354 1.00 75.18  ? -8  U   B O2    1 
ATOM   5846 N  N3    . U   B 2 31  ? 162.391 124.641 164.604 1.00 72.06  ? -8  U   B N3    1 
ATOM   5847 C  C4    . U   B 2 31  ? 163.020 125.042 163.445 1.00 69.61  ? -8  U   B C4    1 
ATOM   5848 O  O4    . U   B 2 31  ? 162.683 126.094 162.903 1.00 68.80  ? -8  U   B O4    1 
ATOM   5849 C  C5    . U   B 2 31  ? 164.035 124.153 162.984 1.00 70.51  ? -8  U   B C5    1 
ATOM   5850 C  C6    . U   B 2 31  ? 164.295 123.043 163.676 1.00 75.87  ? -8  U   B C6    1 
ATOM   5851 P  P     . A   B 2 32  ? 162.032 117.958 162.861 1.00 99.25  ? -7  A   B P     1 
ATOM   5852 O  OP1   . A   B 2 32  ? 161.755 116.502 162.884 1.00 98.34  ? -7  A   B OP1   1 
ATOM   5853 O  OP2   . A   B 2 32  ? 162.480 118.596 161.598 1.00 88.80  ? -7  A   B OP2   1 
ATOM   5854 O  "O5'" . A   B 2 32  ? 160.727 118.710 163.379 1.00 95.61  ? -7  A   B "O5'" 1 
ATOM   5855 C  "C5'" . A   B 2 32  ? 160.133 118.351 164.617 1.00 89.61  ? -7  A   B "C5'" 1 
ATOM   5856 C  "C4'" . A   B 2 32  ? 159.004 119.276 164.999 1.00 86.75  ? -7  A   B "C4'" 1 
ATOM   5857 O  "O4'" . A   B 2 32  ? 159.506 120.602 165.308 1.00 82.92  ? -7  A   B "O4'" 1 
ATOM   5858 C  "C3'" . A   B 2 32  ? 157.949 119.535 163.941 1.00 82.57  ? -7  A   B "C3'" 1 
ATOM   5859 O  "O3'" . A   B 2 32  ? 157.039 118.461 163.787 1.00 87.33  ? -7  A   B "O3'" 1 
ATOM   5860 C  "C2'" . A   B 2 32  ? 157.302 120.820 164.444 1.00 79.89  ? -7  A   B "C2'" 1 
ATOM   5861 O  "O2'" . A   B 2 32  ? 156.402 120.542 165.505 1.00 81.39  ? -7  A   B "O2'" 1 
ATOM   5862 C  "C1'" . A   B 2 32  ? 158.510 121.563 165.018 1.00 77.55  ? -7  A   B "C1'" 1 
ATOM   5863 N  N9    . A   B 2 32  ? 159.043 122.561 164.070 1.00 68.60  ? -7  A   B N9    1 
ATOM   5864 C  C8    . A   B 2 32  ? 160.096 122.442 163.203 1.00 70.23  ? -7  A   B C8    1 
ATOM   5865 N  N7    . A   B 2 32  ? 160.311 123.517 162.486 1.00 63.71  ? -7  A   B N7    1 
ATOM   5866 C  C5    . A   B 2 32  ? 159.333 124.403 162.908 1.00 58.94  ? -7  A   B C5    1 
ATOM   5867 C  C6    . A   B 2 32  ? 159.023 125.719 162.533 1.00 52.08  ? -7  A   B C6    1 
ATOM   5868 N  N6    . A   B 2 32  ? 159.700 126.401 161.607 1.00 46.72  ? -7  A   B N6    1 
ATOM   5869 N  N1    . A   B 2 32  ? 157.985 126.322 163.149 1.00 46.40  ? -7  A   B N1    1 
ATOM   5870 C  C2    . A   B 2 32  ? 157.308 125.642 164.074 1.00 42.72  ? -7  A   B C2    1 
ATOM   5871 N  N3    . A   B 2 32  ? 157.504 124.402 164.510 1.00 52.51  ? -7  A   B N3    1 
ATOM   5872 C  C4    . A   B 2 32  ? 158.543 123.829 163.880 1.00 61.32  ? -7  A   B C4    1 
ATOM   5873 P  P     . A   B 2 33  ? 156.963 117.667 162.393 1.00 102.11 ? -6  A   B P     1 
ATOM   5874 O  OP1   . A   B 2 33  ? 155.795 116.753 162.448 1.00 94.78  ? -6  A   B OP1   1 
ATOM   5875 O  OP2   . A   B 2 33  ? 158.312 117.125 162.095 1.00 94.63  ? -6  A   B OP2   1 
ATOM   5876 O  "O5'" . A   B 2 33  ? 156.653 118.801 161.320 1.00 90.54  ? -6  A   B "O5'" 1 
ATOM   5877 C  "C5'" . A   B 2 33  ? 155.351 118.956 160.776 1.00 85.35  ? -6  A   B "C5'" 1 
ATOM   5878 C  "C4'" . A   B 2 33  ? 154.442 119.699 161.722 1.00 82.98  ? -6  A   B "C4'" 1 
ATOM   5879 O  "O4'" . A   B 2 33  ? 155.127 120.849 162.267 1.00 79.13  ? -6  A   B "O4'" 1 
ATOM   5880 C  "C3'" . A   B 2 33  ? 153.177 120.273 161.113 1.00 75.07  ? -6  A   B "C3'" 1 
ATOM   5881 O  "O3'" . A   B 2 33  ? 152.156 119.301 161.020 1.00 79.57  ? -6  A   B "O3'" 1 
ATOM   5882 C  "C2'" . A   B 2 33  ? 152.825 121.418 162.061 1.00 67.51  ? -6  A   B "C2'" 1 
ATOM   5883 O  "O2'" . A   B 2 33  ? 152.103 120.936 163.184 1.00 68.83  ? -6  A   B "O2'" 1 
ATOM   5884 C  "C1'" . A   B 2 33  ? 154.202 121.876 162.538 1.00 67.06  ? -6  A   B "C1'" 1 
ATOM   5885 N  N9    . A   B 2 33  ? 154.677 123.124 161.911 1.00 53.80  ? -6  A   B N9    1 
ATOM   5886 C  C8    . A   B 2 33  ? 155.628 123.252 160.937 1.00 52.06  ? -6  A   B C8    1 
ATOM   5887 N  N7    . A   B 2 33  ? 155.873 124.491 160.603 1.00 44.03  ? -6  A   B N7    1 
ATOM   5888 C  C5    . A   B 2 33  ? 155.036 125.228 161.425 1.00 39.18  ? -6  A   B C5    1 
ATOM   5889 C  C6    . A   B 2 33  ? 154.826 126.606 161.555 1.00 35.09  ? -6  A   B C6    1 
ATOM   5890 N  N6    . A   B 2 33  ? 155.471 127.517 160.828 1.00 32.60  ? -6  A   B N6    1 
ATOM   5891 N  N1    . A   B 2 33  ? 153.924 127.019 162.465 1.00 28.29  ? -6  A   B N1    1 
ATOM   5892 C  C2    . A   B 2 33  ? 153.283 126.096 163.189 1.00 32.21  ? -6  A   B C2    1 
ATOM   5893 N  N3    . A   B 2 33  ? 153.396 124.774 163.158 1.00 36.77  ? -6  A   B N3    1 
ATOM   5894 C  C4    . A   B 2 33  ? 154.301 124.400 162.243 1.00 41.08  ? -6  A   B C4    1 
ATOM   5895 P  P     . A   B 2 34  ? 151.783 118.633 159.610 1.00 90.81  ? -5  A   B P     1 
ATOM   5896 O  OP1   . A   B 2 34  ? 152.072 117.180 159.714 1.00 84.31  ? -5  A   B OP1   1 
ATOM   5897 O  OP2   . A   B 2 34  ? 152.401 119.431 158.522 1.00 82.42  ? -5  A   B OP2   1 
ATOM   5898 O  "O5'" . A   B 2 34  ? 150.205 118.806 159.548 1.00 77.80  ? -5  A   B "O5'" 1 
ATOM   5899 C  "C5'" . A   B 2 34  ? 149.421 118.572 160.708 1.00 76.15  ? -5  A   B "C5'" 1 
ATOM   5900 C  "C4'" . A   B 2 34  ? 148.687 119.814 161.147 1.00 71.44  ? -5  A   B "C4'" 1 
ATOM   5901 O  "O4'" . A   B 2 34  ? 149.624 120.842 161.546 1.00 68.49  ? -5  A   B "O4'" 1 
ATOM   5902 C  "C3'" . A   B 2 34  ? 147.833 120.485 160.090 1.00 65.14  ? -5  A   B "C3'" 1 
ATOM   5903 O  "O3'" . A   B 2 34  ? 146.584 119.843 159.941 1.00 63.99  ? -5  A   B "O3'" 1 
ATOM   5904 C  "C2'" . A   B 2 34  ? 147.722 121.919 160.598 1.00 61.25  ? -5  A   B "C2'" 1 
ATOM   5905 O  "O2'" . A   B 2 34  ? 146.695 122.023 161.573 1.00 58.70  ? -5  A   B "O2'" 1 
ATOM   5906 C  "C1'" . A   B 2 34  ? 149.071 122.117 161.293 1.00 59.57  ? -5  A   B "C1'" 1 
ATOM   5907 N  N9    . A   B 2 34  ? 150.036 122.923 160.516 1.00 49.98  ? -5  A   B N9    1 
ATOM   5908 C  C8    . A   B 2 34  ? 150.962 122.511 159.596 1.00 52.98  ? -5  A   B C8    1 
ATOM   5909 N  N7    . A   B 2 34  ? 151.696 123.480 159.110 1.00 46.42  ? -5  A   B N7    1 
ATOM   5910 C  C5    . A   B 2 34  ? 151.224 124.609 159.756 1.00 36.29  ? -5  A   B C5    1 
ATOM   5911 C  C6    . A   B 2 34  ? 151.576 125.964 159.680 1.00 26.12  ? -5  A   B C6    1 
ATOM   5912 N  N6    . A   B 2 34  ? 152.532 126.445 158.888 1.00 23.97  ? -5  A   B N6    1 
ATOM   5913 N  N1    . A   B 2 34  ? 150.903 126.829 160.459 1.00 22.38  ? -5  A   B N1    1 
ATOM   5914 C  C2    . A   B 2 34  ? 149.944 126.358 161.252 1.00 28.36  ? -5  A   B C2    1 
ATOM   5915 N  N3    . A   B 2 34  ? 149.521 125.114 161.410 1.00 37.58  ? -5  A   B N3    1 
ATOM   5916 C  C4    . A   B 2 34  ? 150.209 124.278 160.623 1.00 39.62  ? -5  A   B C4    1 
ATOM   5917 P  P     . C   B 2 35  ? 145.517 120.396 158.884 1.00 82.92  ? -4  C   B P     1 
ATOM   5918 O  OP1   . C   B 2 35  ? 144.521 119.326 158.623 1.00 88.64  ? -4  C   B OP1   1 
ATOM   5919 O  OP2   . C   B 2 35  ? 146.266 121.007 157.758 1.00 70.56  ? -4  C   B OP2   1 
ATOM   5920 O  "O5'" . C   B 2 35  ? 144.779 121.564 159.670 1.00 67.37  ? -4  C   B "O5'" 1 
ATOM   5921 C  "C5'" . C   B 2 35  ? 144.084 122.565 158.954 1.00 57.39  ? -4  C   B "C5'" 1 
ATOM   5922 C  "C4'" . C   B 2 35  ? 143.971 123.852 159.727 1.00 44.65  ? -4  C   B "C4'" 1 
ATOM   5923 O  "O4'" . C   B 2 35  ? 145.265 124.254 160.241 1.00 41.94  ? -4  C   B "O4'" 1 
ATOM   5924 C  "C3'" . C   B 2 35  ? 143.530 125.038 158.897 1.00 41.12  ? -4  C   B "C3'" 1 
ATOM   5925 O  "O3'" . C   B 2 35  ? 142.138 125.051 158.654 1.00 43.92  ? -4  C   B "O3'" 1 
ATOM   5926 C  "C2'" . C   B 2 35  ? 144.054 126.218 159.697 1.00 33.23  ? -4  C   B "C2'" 1 
ATOM   5927 O  "O2'" . C   B 2 35  ? 143.226 126.466 160.820 1.00 38.82  ? -4  C   B "O2'" 1 
ATOM   5928 C  "C1'" . C   B 2 35  ? 145.383 125.662 160.196 1.00 35.45  ? -4  C   B "C1'" 1 
ATOM   5929 N  N1    . C   B 2 35  ? 146.514 125.999 159.303 1.00 32.42  ? -4  C   B N1    1 
ATOM   5930 C  C2    . C   B 2 35  ? 146.993 127.310 159.200 1.00 24.45  ? -4  C   B C2    1 
ATOM   5931 O  O2    . C   B 2 35  ? 146.445 128.209 159.850 1.00 20.71  ? -4  C   B O2    1 
ATOM   5932 N  N3    . C   B 2 35  ? 148.035 127.563 158.382 1.00 20.15  ? -4  C   B N3    1 
ATOM   5933 C  C4    . C   B 2 35  ? 148.599 126.575 157.700 1.00 22.20  ? -4  C   B C4    1 
ATOM   5934 N  N4    . C   B 2 35  ? 149.623 126.857 156.904 1.00 23.61  ? -4  C   B N4    1 
ATOM   5935 C  C5    . C   B 2 35  ? 148.143 125.239 157.788 1.00 26.89  ? -4  C   B C5    1 
ATOM   5936 C  C6    . C   B 2 35  ? 147.112 124.999 158.596 1.00 33.69  ? -4  C   B C6    1 
ATOM   5937 P  P     . A   B 2 36  ? 141.614 125.116 157.141 1.00 48.69  ? -3  A   B P     1 
ATOM   5938 O  OP1   . A   B 2 36  ? 140.145 124.919 157.170 1.00 49.13  ? -3  A   B OP1   1 
ATOM   5939 O  OP2   . A   B 2 36  ? 142.458 124.218 156.317 1.00 37.15  ? -3  A   B OP2   1 
ATOM   5940 O  "O5'" . A   B 2 36  ? 141.923 126.620 156.721 1.00 39.77  ? -3  A   B "O5'" 1 
ATOM   5941 C  "C5'" . A   B 2 36  ? 141.420 127.680 157.514 1.00 31.51  ? -3  A   B "C5'" 1 
ATOM   5942 C  "C4'" . A   B 2 36  ? 142.104 128.994 157.246 1.00 27.28  ? -3  A   B "C4'" 1 
ATOM   5943 O  "O4'" . A   B 2 36  ? 143.504 128.939 157.590 1.00 25.63  ? -3  A   B "O4'" 1 
ATOM   5944 C  "C3'" . A   B 2 36  ? 142.118 129.490 155.819 1.00 28.66  ? -3  A   B "C3'" 1 
ATOM   5945 O  "O3'" . A   B 2 36  ? 140.864 129.993 155.406 1.00 38.99  ? -3  A   B "O3'" 1 
ATOM   5946 C  "C2'" . A   B 2 36  ? 143.218 130.546 155.861 1.00 21.87  ? -3  A   B "C2'" 1 
ATOM   5947 O  "O2'" . A   B 2 36  ? 142.733 131.757 156.412 1.00 24.77  ? -3  A   B "O2'" 1 
ATOM   5948 C  "C1'" . A   B 2 36  ? 144.195 129.934 156.865 1.00 18.62  ? -3  A   B "C1'" 1 
ATOM   5949 N  N9    . A   B 2 36  ? 145.399 129.363 156.238 1.00 17.80  ? -3  A   B N9    1 
ATOM   5950 C  C8    . A   B 2 36  ? 145.689 128.059 155.954 1.00 18.04  ? -3  A   B C8    1 
ATOM   5951 N  N7    . A   B 2 36  ? 146.863 127.893 155.408 1.00 13.07  ? -3  A   B N7    1 
ATOM   5952 C  C5    . A   B 2 36  ? 147.379 129.172 155.336 1.00 13.54  ? -3  A   B C5    1 
ATOM   5953 C  C6    . A   B 2 36  ? 148.594 129.679 154.859 1.00 13.43  ? -3  A   B C6    1 
ATOM   5954 N  N6    . A   B 2 36  ? 149.560 128.926 154.335 1.00 12.64  ? -3  A   B N6    1 
ATOM   5955 N  N1    . A   B 2 36  ? 148.789 131.007 154.932 1.00 11.78  ? -3  A   B N1    1 
ATOM   5956 C  C2    . A   B 2 36  ? 147.834 131.772 155.456 1.00 11.02  ? -3  A   B C2    1 
ATOM   5957 N  N3    . A   B 2 36  ? 146.654 131.411 155.939 1.00 12.71  ? -3  A   B N3    1 
ATOM   5958 C  C4    . A   B 2 36  ? 146.489 130.085 155.846 1.00 14.20  ? -3  A   B C4    1 
ATOM   5959 P  P     . A   B 2 37  ? 140.443 129.933 153.862 1.00 39.34  ? -2  A   B P     1 
ATOM   5960 O  OP1   . A   B 2 37  ? 138.965 129.978 153.793 1.00 41.67  ? -2  A   B OP1   1 
ATOM   5961 O  OP2   . A   B 2 37  ? 141.189 128.824 153.224 1.00 24.73  ? -2  A   B OP2   1 
ATOM   5962 O  "O5'" . A   B 2 37  ? 141.000 131.297 153.273 1.00 25.94  ? -2  A   B "O5'" 1 
ATOM   5963 C  "C5'" . A   B 2 37  ? 140.767 132.519 153.949 1.00 24.48  ? -2  A   B "C5'" 1 
ATOM   5964 C  "C4'" . A   B 2 37  ? 141.740 133.573 153.510 1.00 22.41  ? -2  A   B "C4'" 1 
ATOM   5965 O  "O4'" . A   B 2 37  ? 143.052 133.290 154.055 1.00 27.39  ? -2  A   B "O4'" 1 
ATOM   5966 C  "C3'" . A   B 2 37  ? 141.982 133.644 152.019 1.00 29.71  ? -2  A   B "C3'" 1 
ATOM   5967 O  "O3'" . A   B 2 37  ? 140.954 134.311 151.315 1.00 34.09  ? -2  A   B "O3'" 1 
ATOM   5968 C  "C2'" . A   B 2 37  ? 143.342 134.322 151.939 1.00 32.25  ? -2  A   B "C2'" 1 
ATOM   5969 O  "O2'" . A   B 2 37  ? 143.220 135.717 152.167 1.00 33.72  ? -2  A   B "O2'" 1 
ATOM   5970 C  "C1'" . A   B 2 37  ? 144.049 133.702 153.141 1.00 26.92  ? -2  A   B "C1'" 1 
ATOM   5971 N  N9    . A   B 2 37  ? 144.887 132.536 152.789 1.00 16.31  ? -2  A   B N9    1 
ATOM   5972 C  C8    . A   B 2 37  ? 144.553 131.212 152.858 1.00 14.70  ? -2  A   B C8    1 
ATOM   5973 N  N7    . A   B 2 37  ? 145.506 130.394 152.505 1.00 13.74  ? -2  A   B N7    1 
ATOM   5974 C  C5    . A   B 2 37  ? 146.549 131.239 152.175 1.00 14.20  ? -2  A   B C5    1 
ATOM   5975 C  C6    . A   B 2 37  ? 147.852 130.994 151.718 1.00 10.74  ? -2  A   B C6    1 
ATOM   5976 N  N6    . A   B 2 37  ? 148.336 129.777 151.505 1.00 8.52   ? -2  A   B N6    1 
ATOM   5977 N  N1    . A   B 2 37  ? 148.648 132.051 151.475 1.00 9.99   ? -2  A   B N1    1 
ATOM   5978 C  C2    . A   B 2 37  ? 148.159 133.273 151.687 1.00 11.72  ? -2  A   B C2    1 
ATOM   5979 N  N3    . A   B 2 37  ? 146.956 133.632 152.119 1.00 14.87  ? -2  A   B N3    1 
ATOM   5980 C  C4    . A   B 2 37  ? 146.186 132.558 152.348 1.00 15.27  ? -2  A   B C4    1 
ATOM   5981 P  P     . C   B 2 38  ? 140.435 133.714 149.920 1.00 38.70  ? -1  C   B P     1 
ATOM   5982 O  OP1   . C   B 2 38  ? 139.189 134.422 149.554 1.00 48.25  ? -1  C   B OP1   1 
ATOM   5983 O  OP2   . C   B 2 38  ? 140.421 132.237 150.018 1.00 31.38  ? -1  C   B OP2   1 
ATOM   5984 O  "O5'" . C   B 2 38  ? 141.580 134.122 148.895 1.00 40.62  ? -1  C   B "O5'" 1 
ATOM   5985 C  "C5'" . C   B 2 38  ? 142.001 135.470 148.792 1.00 38.00  ? -1  C   B "C5'" 1 
ATOM   5986 C  "C4'" . C   B 2 38  ? 143.417 135.589 148.278 1.00 43.57  ? -1  C   B "C4'" 1 
ATOM   5987 O  "O4'" . C   B 2 38  ? 144.336 134.832 149.104 1.00 39.15  ? -1  C   B "O4'" 1 
ATOM   5988 C  "C3'" . C   B 2 38  ? 143.686 135.069 146.881 1.00 36.57  ? -1  C   B "C3'" 1 
ATOM   5989 O  "O3'" . C   B 2 38  ? 143.246 135.963 145.877 1.00 48.64  ? -1  C   B "O3'" 1 
ATOM   5990 C  "C2'" . C   B 2 38  ? 145.199 134.889 146.892 1.00 32.75  ? -1  C   B "C2'" 1 
ATOM   5991 O  "O2'" . C   B 2 38  ? 145.844 136.132 146.688 1.00 32.30  ? -1  C   B "O2'" 1 
ATOM   5992 C  "C1'" . C   B 2 38  ? 145.456 134.453 148.337 1.00 26.04  ? -1  C   B "C1'" 1 
ATOM   5993 N  N1    . C   B 2 38  ? 145.690 132.996 148.459 1.00 16.78  ? -1  C   B N1    1 
ATOM   5994 C  C2    . C   B 2 38  ? 146.985 132.535 148.244 1.00 14.76  ? -1  C   B C2    1 
ATOM   5995 O  O2    . C   B 2 38  ? 147.868 133.358 147.977 1.00 17.65  ? -1  C   B O2    1 
ATOM   5996 N  N3    . C   B 2 38  ? 147.246 131.219 148.336 1.00 14.06  ? -1  C   B N3    1 
ATOM   5997 C  C4    . C   B 2 38  ? 146.261 130.377 148.627 1.00 12.78  ? -1  C   B C4    1 
ATOM   5998 N  N4    . C   B 2 38  ? 146.555 129.083 148.708 1.00 13.68  ? -1  C   B N4    1 
ATOM   5999 C  C5    . C   B 2 38  ? 144.931 130.813 148.845 1.00 12.20  ? -1  C   B C5    1 
ATOM   6000 C  C6    . C   B 2 38  ? 144.690 132.122 148.752 1.00 16.67  ? -1  C   B C6    1 
ATOM   6001 P  P     . G   B 2 39  ? 141.830 135.762 145.148 1.00 52.77  ? 0   G   B P     1 
ATOM   6002 O  OP1   . G   B 2 39  ? 140.791 136.455 145.942 1.00 45.78  ? 0   G   B OP1   1 
ATOM   6003 O  OP2   . G   B 2 39  ? 141.651 134.329 144.825 1.00 43.61  ? 0   G   B OP2   1 
ATOM   6004 O  "O5'" . G   B 2 39  ? 142.003 136.572 143.790 1.00 49.17  ? 0   G   B "O5'" 1 
ATOM   6005 C  "C5'" . G   B 2 39  ? 143.030 136.230 142.868 1.00 37.24  ? 0   G   B "C5'" 1 
ATOM   6006 C  "C4'" . G   B 2 39  ? 143.957 137.387 142.596 1.00 38.43  ? 0   G   B "C4'" 1 
ATOM   6007 O  "O4'" . G   B 2 39  ? 143.545 138.083 141.386 1.00 38.76  ? 0   G   B "O4'" 1 
ATOM   6008 C  "C3'" . G   B 2 39  ? 144.046 138.455 143.689 1.00 37.78  ? 0   G   B "C3'" 1 
ATOM   6009 O  "O3'" . G   B 2 39  ? 145.383 138.948 143.743 1.00 51.22  ? 0   G   B "O3'" 1 
ATOM   6010 C  "C2'" . G   B 2 39  ? 143.164 139.564 143.137 1.00 31.26  ? 0   G   B "C2'" 1 
ATOM   6011 O  "O2'" . G   B 2 39  ? 143.447 140.847 143.649 1.00 34.80  ? 0   G   B "O2'" 1 
ATOM   6012 C  "C1'" . G   B 2 39  ? 143.487 139.465 141.655 1.00 30.54  ? 0   G   B "C1'" 1 
ATOM   6013 N  N9    . G   B 2 39  ? 142.530 140.118 140.758 1.00 32.65  ? 0   G   B N9    1 
ATOM   6014 C  C8    . G   B 2 39  ? 141.314 140.656 141.088 1.00 32.11  ? 0   G   B C8    1 
ATOM   6015 N  N7    . G   B 2 39  ? 140.705 141.192 140.071 1.00 30.22  ? 0   G   B N7    1 
ATOM   6016 C  C5    . G   B 2 39  ? 141.573 141.005 139.009 1.00 25.05  ? 0   G   B C5    1 
ATOM   6017 C  C6    . G   B 2 39  ? 141.450 141.379 137.654 1.00 24.29  ? 0   G   B C6    1 
ATOM   6018 O  O6    . G   B 2 39  ? 140.511 141.961 137.111 1.00 23.65  ? 0   G   B O6    1 
ATOM   6019 N  N1    . G   B 2 39  ? 142.559 140.998 136.915 1.00 24.77  ? 0   G   B N1    1 
ATOM   6020 C  C2    . G   B 2 39  ? 143.650 140.342 137.420 1.00 25.05  ? 0   G   B C2    1 
ATOM   6021 N  N2    . G   B 2 39  ? 144.630 140.059 136.554 1.00 21.66  ? 0   G   B N2    1 
ATOM   6022 N  N3    . G   B 2 39  ? 143.775 139.989 138.683 1.00 25.54  ? 0   G   B N3    1 
ATOM   6023 C  C4    . G   B 2 39  ? 142.707 140.351 139.417 1.00 27.08  ? 0   G   B C4    1 
ATOM   6024 P  P     . G   B 2 40  ? 146.390 138.477 144.899 1.00 58.52  ? 1   G   B P     1 
ATOM   6025 O  OP1   . G   B 2 40  ? 146.569 137.011 144.783 1.00 47.07  ? 1   G   B OP1   1 
ATOM   6026 O  OP2   . G   B 2 40  ? 145.940 139.066 146.181 1.00 42.87  ? 1   G   B OP2   1 
ATOM   6027 O  "O5'" . G   B 2 40  ? 147.768 139.152 144.494 1.00 42.57  ? 1   G   B "O5'" 1 
ATOM   6028 C  "C5'" . G   B 2 40  ? 147.804 140.471 143.976 1.00 39.90  ? 1   G   B "C5'" 1 
ATOM   6029 C  "C4'" . G   B 2 40  ? 148.309 140.493 142.555 1.00 44.03  ? 1   G   B "C4'" 1 
ATOM   6030 O  "O4'" . G   B 2 40  ? 147.194 140.359 141.645 1.00 42.86  ? 1   G   B "O4'" 1 
ATOM   6031 C  "C3'" . G   B 2 40  ? 149.003 141.774 142.123 1.00 37.65  ? 1   G   B "C3'" 1 
ATOM   6032 O  "O3'" . G   B 2 40  ? 150.374 141.763 142.479 1.00 31.87  ? 1   G   B "O3'" 1 
ATOM   6033 C  "C2'" . G   B 2 40  ? 148.770 141.814 140.613 1.00 32.10  ? 1   G   B "C2'" 1 
ATOM   6034 O  "O2'" . G   B 2 40  ? 149.749 141.048 139.932 1.00 29.77  ? 1   G   B "O2'" 1 
ATOM   6035 C  "C1'" . G   B 2 40  ? 147.431 141.099 140.470 1.00 31.78  ? 1   G   B "C1'" 1 
ATOM   6036 N  N9    . G   B 2 40  ? 146.264 141.968 140.219 1.00 30.25  ? 1   G   B N9    1 
ATOM   6037 C  C8    . G   B 2 40  ? 145.258 142.211 141.115 1.00 26.68  ? 1   G   B C8    1 
ATOM   6038 N  N7    . G   B 2 40  ? 144.304 142.953 140.642 1.00 23.44  ? 1   G   B N7    1 
ATOM   6039 C  C5    . G   B 2 40  ? 144.688 143.199 139.339 1.00 22.27  ? 1   G   B C5    1 
ATOM   6040 C  C6    . G   B 2 40  ? 144.040 143.955 138.341 1.00 21.27  ? 1   G   B C6    1 
ATOM   6041 O  O6    . G   B 2 40  ? 142.969 144.557 138.428 1.00 25.84  ? 1   G   B O6    1 
ATOM   6042 N  N1    . G   B 2 40  ? 144.755 143.959 137.156 1.00 21.09  ? 1   G   B N1    1 
ATOM   6043 C  C2    . G   B 2 40  ? 145.950 143.320 136.962 1.00 22.42  ? 1   G   B C2    1 
ATOM   6044 N  N2    . G   B 2 40  ? 146.500 143.440 135.750 1.00 23.26  ? 1   G   B N2    1 
ATOM   6045 N  N3    . G   B 2 40  ? 146.566 142.611 137.888 1.00 25.27  ? 1   G   B N3    1 
ATOM   6046 C  C4    . G   B 2 40  ? 145.885 142.590 139.051 1.00 26.56  ? 1   G   B C4    1 
ATOM   6047 P  P     . A   B 2 41  ? 151.111 143.105 142.954 1.00 48.25  ? 2   A   B P     1 
ATOM   6048 O  OP1   . A   B 2 41  ? 152.332 142.741 143.706 1.00 52.71  ? 2   A   B OP1   1 
ATOM   6049 O  OP2   . A   B 2 41  ? 150.097 143.980 143.582 1.00 32.93  ? 2   A   B OP2   1 
ATOM   6050 O  "O5'" . A   B 2 41  ? 151.579 143.782 141.596 1.00 33.50  ? 2   A   B "O5'" 1 
ATOM   6051 C  "C5'" . A   B 2 41  ? 152.179 143.022 140.560 1.00 19.65  ? 2   A   B "C5'" 1 
ATOM   6052 C  "C4'" . A   B 2 41  ? 152.124 143.775 139.259 1.00 21.71  ? 2   A   B "C4'" 1 
ATOM   6053 O  "O4'" . A   B 2 41  ? 150.831 143.594 138.634 1.00 20.79  ? 2   A   B "O4'" 1 
ATOM   6054 C  "C3'" . A   B 2 41  ? 152.255 145.277 139.386 1.00 26.31  ? 2   A   B "C3'" 1 
ATOM   6055 O  "O3'" . A   B 2 41  ? 153.593 145.701 139.521 1.00 21.79  ? 2   A   B "O3'" 1 
ATOM   6056 C  "C2'" . A   B 2 41  ? 151.577 145.780 138.124 1.00 23.93  ? 2   A   B "C2'" 1 
ATOM   6057 O  "O2'" . A   B 2 41  ? 152.439 145.629 137.008 1.00 22.95  ? 2   A   B "O2'" 1 
ATOM   6058 C  "C1'" . A   B 2 41  ? 150.445 144.781 137.975 1.00 19.53  ? 2   A   B "C1'" 1 
ATOM   6059 N  N9    . A   B 2 41  ? 149.161 145.243 138.542 1.00 23.23  ? 2   A   B N9    1 
ATOM   6060 C  C8    . A   B 2 41  ? 148.660 144.970 139.785 1.00 19.88  ? 2   A   B C8    1 
ATOM   6061 N  N7    . A   B 2 41  ? 147.476 145.464 140.012 1.00 21.88  ? 2   A   B N7    1 
ATOM   6062 C  C5    . A   B 2 41  ? 147.160 146.106 138.828 1.00 20.23  ? 2   A   B C5    1 
ATOM   6063 C  C6    . A   B 2 41  ? 146.032 146.833 138.429 1.00 16.43  ? 2   A   B C6    1 
ATOM   6064 N  N6    . A   B 2 41  ? 144.977 147.039 139.208 1.00 13.29  ? 2   A   B N6    1 
ATOM   6065 N  N1    . A   B 2 41  ? 146.023 147.347 137.188 1.00 15.84  ? 2   A   B N1    1 
ATOM   6066 C  C2    . A   B 2 41  ? 147.084 147.141 136.405 1.00 15.86  ? 2   A   B C2    1 
ATOM   6067 N  N3    . A   B 2 41  ? 148.202 146.477 136.665 1.00 19.68  ? 2   A   B N3    1 
ATOM   6068 C  C4    . A   B 2 41  ? 148.182 145.975 137.911 1.00 21.69  ? 2   A   B C4    1 
ATOM   6069 P  P     . G   B 2 42  ? 153.921 146.975 140.425 1.00 26.12  ? 3   G   B P     1 
ATOM   6070 O  OP1   . G   B 2 42  ? 155.388 147.032 140.614 1.00 41.96  ? 3   G   B OP1   1 
ATOM   6071 O  OP2   . G   B 2 42  ? 153.016 146.927 141.595 1.00 19.32  ? 3   G   B OP2   1 
ATOM   6072 O  "O5'" . G   B 2 42  ? 153.483 148.199 139.514 1.00 21.70  ? 3   G   B "O5'" 1 
ATOM   6073 C  "C5'" . G   B 2 42  ? 153.984 148.325 138.196 1.00 22.02  ? 3   G   B "C5'" 1 
ATOM   6074 C  "C4'" . G   B 2 42  ? 153.150 149.262 137.363 1.00 24.30  ? 3   G   B "C4'" 1 
ATOM   6075 O  "O4'" . G   B 2 42  ? 151.835 148.704 137.115 1.00 24.56  ? 3   G   B "O4'" 1 
ATOM   6076 C  "C3'" . G   B 2 42  ? 152.841 150.612 137.967 1.00 26.29  ? 3   G   B "C3'" 1 
ATOM   6077 O  "O3'" . G   B 2 42  ? 153.929 151.510 137.935 1.00 29.85  ? 3   G   B "O3'" 1 
ATOM   6078 C  "C2'" . G   B 2 42  ? 151.655 151.060 137.132 1.00 27.04  ? 3   G   B "C2'" 1 
ATOM   6079 O  "O2'" . G   B 2 42  ? 152.086 151.456 135.840 1.00 29.66  ? 3   G   B "O2'" 1 
ATOM   6080 C  "C1'" . G   B 2 42  ? 150.894 149.750 136.990 1.00 21.83  ? 3   G   B "C1'" 1 
ATOM   6081 N  N9    . G   B 2 42  ? 149.864 149.606 138.035 1.00 17.59  ? 3   G   B N9    1 
ATOM   6082 C  C8    . G   B 2 42  ? 149.988 148.971 139.238 1.00 16.20  ? 3   G   B C8    1 
ATOM   6083 N  N7    . G   B 2 42  ? 148.898 149.011 139.946 1.00 17.31  ? 3   G   B N7    1 
ATOM   6084 C  C5    . G   B 2 42  ? 147.996 149.715 139.166 1.00 15.76  ? 3   G   B C5    1 
ATOM   6085 C  C6    . G   B 2 42  ? 146.649 150.074 139.414 1.00 15.65  ? 3   G   B C6    1 
ATOM   6086 O  O6    . G   B 2 42  ? 145.963 149.823 140.406 1.00 17.91  ? 3   G   B O6    1 
ATOM   6087 N  N1    . G   B 2 42  ? 146.101 150.784 138.357 1.00 13.77  ? 3   G   B N1    1 
ATOM   6088 C  C2    . G   B 2 42  ? 146.775 151.109 137.216 1.00 16.21  ? 3   G   B C2    1 
ATOM   6089 N  N2    . G   B 2 42  ? 146.095 151.804 136.298 1.00 19.66  ? 3   G   B N2    1 
ATOM   6090 N  N3    . G   B 2 42  ? 148.029 150.785 136.976 1.00 16.18  ? 3   G   B N3    1 
ATOM   6091 C  C4    . G   B 2 42  ? 148.580 150.092 137.988 1.00 16.26  ? 3   G   B C4    1 
ATOM   6092 P  P     . A   B 2 43  ? 154.005 152.676 139.026 1.00 31.69  ? 4   A   B P     1 
ATOM   6093 O  OP1   . A   B 2 43  ? 155.351 153.281 138.979 1.00 38.90  ? 4   A   B OP1   1 
ATOM   6094 O  OP2   . A   B 2 43  ? 153.491 152.111 140.291 1.00 24.91  ? 4   A   B OP2   1 
ATOM   6095 O  "O5'" . A   B 2 43  ? 152.944 153.746 138.518 1.00 30.67  ? 4   A   B "O5'" 1 
ATOM   6096 C  "C5'" . A   B 2 43  ? 153.050 154.336 137.232 1.00 25.17  ? 4   A   B "C5'" 1 
ATOM   6097 C  "C4'" . A   B 2 43  ? 151.748 154.970 136.824 1.00 25.36  ? 4   A   B "C4'" 1 
ATOM   6098 O  "O4'" . A   B 2 43  ? 150.684 153.997 136.943 1.00 25.17  ? 4   A   B "O4'" 1 
ATOM   6099 C  "C3'" . A   B 2 43  ? 151.283 156.128 137.681 1.00 26.90  ? 4   A   B "C3'" 1 
ATOM   6100 O  "O3'" . A   B 2 43  ? 151.900 157.348 137.326 1.00 33.56  ? 4   A   B "O3'" 1 
ATOM   6101 C  "C2'" . A   B 2 43  ? 149.775 156.123 137.467 1.00 29.09  ? 4   A   B "C2'" 1 
ATOM   6102 O  "O2'" . A   B 2 43  ? 149.433 156.751 136.242 1.00 28.55  ? 4   A   B "O2'" 1 
ATOM   6103 C  "C1'" . A   B 2 43  ? 149.489 154.632 137.335 1.00 22.47  ? 4   A   B "C1'" 1 
ATOM   6104 N  N9    . A   B 2 43  ? 149.026 154.017 138.590 1.00 15.45  ? 4   A   B N9    1 
ATOM   6105 C  C8    . A   B 2 43  ? 149.751 153.242 139.449 1.00 14.47  ? 4   A   B C8    1 
ATOM   6106 N  N7    . A   B 2 43  ? 149.065 152.813 140.472 1.00 16.03  ? 4   A   B N7    1 
ATOM   6107 C  C5    . A   B 2 43  ? 147.802 153.337 140.269 1.00 15.16  ? 4   A   B C5    1 
ATOM   6108 C  C6    . A   B 2 43  ? 146.616 153.247 141.004 1.00 12.74  ? 4   A   B C6    1 
ATOM   6109 N  N6    . A   B 2 43  ? 146.508 152.567 142.141 1.00 12.47  ? 4   A   B N6    1 
ATOM   6110 N  N1    . A   B 2 43  ? 145.532 153.885 140.528 1.00 13.40  ? 4   A   B N1    1 
ATOM   6111 C  C2    . A   B 2 43  ? 145.645 154.565 139.388 1.00 14.78  ? 4   A   B C2    1 
ATOM   6112 N  N3    . A   B 2 43  ? 146.703 154.726 138.608 1.00 17.64  ? 4   A   B N3    1 
ATOM   6113 C  C4    . A   B 2 43  ? 147.761 154.078 139.110 1.00 16.65  ? 4   A   B C4    1 
ATOM   6114 P  P     . U   B 2 44  ? 152.170 158.463 138.441 1.00 34.26  ? 5   U   B P     1 
ATOM   6115 O  OP1   . U   B 2 44  ? 153.152 159.423 137.896 1.00 30.55  ? 5   U   B OP1   1 
ATOM   6116 O  OP2   . U   B 2 44  ? 152.464 157.755 139.705 1.00 29.00  ? 5   U   B OP2   1 
ATOM   6117 O  "O5'" . U   B 2 44  ? 150.763 159.186 138.618 1.00 33.15  ? 5   U   B "O5'" 1 
ATOM   6118 C  "C5'" . U   B 2 44  ? 150.108 159.812 137.527 1.00 24.76  ? 5   U   B "C5'" 1 
ATOM   6119 C  "C4'" . U   B 2 44  ? 148.635 159.996 137.796 1.00 28.18  ? 5   U   B "C4'" 1 
ATOM   6120 O  "O4'" . U   B 2 44  ? 148.018 158.712 138.052 1.00 24.71  ? 5   U   B "O4'" 1 
ATOM   6121 C  "C3'" . U   B 2 44  ? 148.267 160.828 139.014 1.00 31.79  ? 5   U   B "C3'" 1 
ATOM   6122 O  "O3'" . U   B 2 44  ? 148.317 162.217 138.754 1.00 40.62  ? 5   U   B "O3'" 1 
ATOM   6123 C  "C2'" . U   B 2 44  ? 146.867 160.335 139.344 1.00 30.85  ? 5   U   B "C2'" 1 
ATOM   6124 O  "O2'" . U   B 2 44  ? 145.920 160.930 138.470 1.00 35.72  ? 5   U   B "O2'" 1 
ATOM   6125 C  "C1'" . U   B 2 44  ? 146.967 158.858 138.983 1.00 25.39  ? 5   U   B "C1'" 1 
ATOM   6126 N  N1    . U   B 2 44  ? 147.237 157.980 140.143 1.00 21.50  ? 5   U   B N1    1 
ATOM   6127 C  C2    . U   B 2 44  ? 146.200 157.641 140.987 1.00 22.16  ? 5   U   B C2    1 
ATOM   6128 O  O2    . U   B 2 44  ? 145.065 158.054 140.859 1.00 25.94  ? 5   U   B O2    1 
ATOM   6129 N  N3    . U   B 2 44  ? 146.537 156.803 142.014 1.00 17.24  ? 5   U   B N3    1 
ATOM   6130 C  C4    . U   B 2 44  ? 147.781 156.274 142.267 1.00 19.11  ? 5   U   B C4    1 
ATOM   6131 O  O4    . U   B 2 44  ? 147.950 155.529 143.225 1.00 18.61  ? 5   U   B O4    1 
ATOM   6132 C  C5    . U   B 2 44  ? 148.793 156.658 141.346 1.00 19.33  ? 5   U   B C5    1 
ATOM   6133 C  C6    . U   B 2 44  ? 148.489 157.473 140.342 1.00 19.24  ? 5   U   B C6    1 
ATOM   6134 P  P     . G   B 2 45  ? 148.577 163.265 139.940 1.00 48.70  ? 6   G   B P     1 
ATOM   6135 O  OP1   . G   B 2 45  ? 148.610 164.615 139.332 1.00 50.68  ? 6   G   B OP1   1 
ATOM   6136 O  OP2   . G   B 2 45  ? 149.735 162.796 140.737 1.00 38.39  ? 6   G   B OP2   1 
ATOM   6137 O  "O5'" . G   B 2 45  ? 147.266 163.171 140.835 1.00 49.88  ? 6   G   B "O5'" 1 
ATOM   6138 C  "C5'" . G   B 2 45  ? 146.037 163.727 140.393 1.00 45.10  ? 6   G   B "C5'" 1 
ATOM   6139 C  "C4'" . G   B 2 45  ? 144.899 163.342 141.305 1.00 36.06  ? 6   G   B "C4'" 1 
ATOM   6140 O  "O4'" . G   B 2 45  ? 144.842 161.902 141.419 1.00 35.08  ? 6   G   B "O4'" 1 
ATOM   6141 C  "C3'" . G   B 2 45  ? 145.000 163.822 142.745 1.00 39.22  ? 6   G   B "C3'" 1 
ATOM   6142 O  "O3'" . G   B 2 45  ? 144.556 165.156 142.907 1.00 44.83  ? 6   G   B "O3'" 1 
ATOM   6143 C  "C2'" . G   B 2 45  ? 144.147 162.813 143.498 1.00 40.54  ? 6   G   B "C2'" 1 
ATOM   6144 O  "O2'" . G   B 2 45  ? 142.771 163.130 143.369 1.00 48.17  ? 6   G   B "O2'" 1 
ATOM   6145 C  "C1'" . G   B 2 45  ? 144.408 161.537 142.709 1.00 32.87  ? 6   G   B "C1'" 1 
ATOM   6146 N  N9    . G   B 2 45  ? 145.420 160.662 143.324 1.00 31.52  ? 6   G   B N9    1 
ATOM   6147 C  C8    . G   B 2 45  ? 146.715 160.462 142.926 1.00 30.37  ? 6   G   B C8    1 
ATOM   6148 N  N7    . G   B 2 45  ? 147.345 159.597 143.667 1.00 26.65  ? 6   G   B N7    1 
ATOM   6149 C  C5    . G   B 2 45  ? 146.403 159.194 144.600 1.00 24.33  ? 6   G   B C5    1 
ATOM   6150 C  C6    . G   B 2 45  ? 146.500 158.277 145.667 1.00 22.25  ? 6   G   B C6    1 
ATOM   6151 O  O6    . G   B 2 45  ? 147.468 157.596 146.008 1.00 20.43  ? 6   G   B O6    1 
ATOM   6152 N  N1    . G   B 2 45  ? 145.304 158.178 146.360 1.00 25.58  ? 6   G   B N1    1 
ATOM   6153 C  C2    . G   B 2 45  ? 144.166 158.880 146.072 1.00 26.54  ? 6   G   B C2    1 
ATOM   6154 N  N2    . G   B 2 45  ? 143.107 158.657 146.856 1.00 27.11  ? 6   G   B N2    1 
ATOM   6155 N  N3    . G   B 2 45  ? 144.062 159.738 145.084 1.00 28.21  ? 6   G   B N3    1 
ATOM   6156 C  C4    . G   B 2 45  ? 145.212 159.841 144.398 1.00 28.70  ? 6   G   B C4    1 
ATOM   6157 P  P     . A   B 2 46  ? 145.068 166.039 144.145 1.00 57.69  ? 7   A   B P     1 
ATOM   6158 O  OP1   . A   B 2 46  ? 144.531 167.409 143.966 1.00 56.15  ? 7   A   B OP1   1 
ATOM   6159 O  OP2   . A   B 2 46  ? 146.531 165.831 144.285 1.00 49.29  ? 7   A   B OP2   1 
ATOM   6160 O  "O5'" . A   B 2 46  ? 144.322 165.412 145.403 1.00 49.88  ? 7   A   B "O5'" 1 
ATOM   6161 C  "C5'" . A   B 2 46  ? 142.907 165.461 145.498 1.00 51.55  ? 7   A   B "C5'" 1 
ATOM   6162 C  "C4'" . A   B 2 46  ? 142.393 164.646 146.657 1.00 51.06  ? 7   A   B "C4'" 1 
ATOM   6163 O  "O4'" . A   B 2 46  ? 142.801 163.266 146.514 1.00 42.98  ? 7   A   B "O4'" 1 
ATOM   6164 C  "C3'" . A   B 2 46  ? 142.914 165.049 148.022 1.00 47.94  ? 7   A   B "C3'" 1 
ATOM   6165 O  "O3'" . A   B 2 46  ? 142.191 166.143 148.552 1.00 50.18  ? 7   A   B "O3'" 1 
ATOM   6166 C  "C2'" . A   B 2 46  ? 142.777 163.767 148.836 1.00 41.73  ? 7   A   B "C2'" 1 
ATOM   6167 O  "O2'" . A   B 2 46  ? 141.443 163.603 149.290 1.00 41.60  ? 7   A   B "O2'" 1 
ATOM   6168 C  "C1'" . A   B 2 46  ? 143.044 162.699 147.781 1.00 37.66  ? 7   A   B "C1'" 1 
ATOM   6169 N  N9    . A   B 2 46  ? 144.414 162.149 147.790 1.00 34.54  ? 7   A   B N9    1 
ATOM   6170 C  C8    . A   B 2 46  ? 145.450 162.481 146.955 1.00 31.50  ? 7   A   B C8    1 
ATOM   6171 N  N7    . A   B 2 46  ? 146.539 161.789 147.161 1.00 27.93  ? 7   A   B N7    1 
ATOM   6172 C  C5    . A   B 2 46  ? 146.192 160.926 148.187 1.00 28.31  ? 7   A   B C5    1 
ATOM   6173 C  C6    . A   B 2 46  ? 146.907 159.928 148.863 1.00 27.57  ? 7   A   B C6    1 
ATOM   6174 N  N6    . A   B 2 46  ? 148.175 159.629 148.592 1.00 23.86  ? 7   A   B N6    1 
ATOM   6175 N  N1    . A   B 2 46  ? 146.279 159.242 149.839 1.00 33.46  ? 7   A   B N1    1 
ATOM   6176 C  C2    . A   B 2 46  ? 145.009 159.553 150.103 1.00 34.57  ? 7   A   B C2    1 
ATOM   6177 N  N3    . A   B 2 46  ? 144.229 160.467 149.538 1.00 34.83  ? 7   A   B N3    1 
ATOM   6178 C  C4    . A   B 2 46  ? 144.887 161.129 148.577 1.00 33.41  ? 7   A   B C4    1 
ATOM   6179 P  P     . G   B 2 47  ? 142.737 166.927 149.835 1.00 69.48  ? 8   G   B P     1 
ATOM   6180 O  OP1   . G   B 2 47  ? 142.012 168.219 149.914 1.00 62.40  ? 8   G   B OP1   1 
ATOM   6181 O  OP2   . G   B 2 47  ? 144.221 166.913 149.790 1.00 49.52  ? 8   G   B OP2   1 
ATOM   6182 O  "O5'" . G   B 2 47  ? 142.248 166.024 151.048 1.00 58.71  ? 8   G   B "O5'" 1 
ATOM   6183 C  "C5'" . G   B 2 47  ? 142.905 166.075 152.298 1.00 49.64  ? 8   G   B "C5'" 1 
ATOM   6184 C  "C4'" . G   B 2 47  ? 142.853 164.745 152.998 1.00 46.09  ? 8   G   B "C4'" 1 
ATOM   6185 O  "O4'" . G   B 2 47  ? 143.209 163.691 152.070 1.00 41.47  ? 8   G   B "O4'" 1 
ATOM   6186 C  "C3'" . G   B 2 47  ? 143.840 164.576 154.136 1.00 50.02  ? 8   G   B "C3'" 1 
ATOM   6187 O  "O3'" . G   B 2 47  ? 143.405 165.181 155.337 1.00 54.44  ? 8   G   B "O3'" 1 
ATOM   6188 C  "C2'" . G   B 2 47  ? 143.996 163.069 154.217 1.00 43.79  ? 8   G   B "C2'" 1 
ATOM   6189 O  "O2'" . G   B 2 47  ? 142.872 162.490 154.861 1.00 42.27  ? 8   G   B "O2'" 1 
ATOM   6190 C  "C1'" . G   B 2 47  ? 143.949 162.692 152.739 1.00 39.21  ? 8   G   B "C1'" 1 
ATOM   6191 N  N9    . G   B 2 47  ? 145.286 162.609 152.114 1.00 35.91  ? 8   G   B N9    1 
ATOM   6192 C  C8    . G   B 2 47  ? 145.740 163.382 151.078 1.00 37.30  ? 8   G   B C8    1 
ATOM   6193 N  N7    . G   B 2 47  ? 146.949 163.090 150.694 1.00 29.38  ? 8   G   B N7    1 
ATOM   6194 C  C5    . G   B 2 47  ? 147.320 162.043 151.518 1.00 29.93  ? 8   G   B C5    1 
ATOM   6195 C  C6    . G   B 2 47  ? 148.531 161.307 151.573 1.00 33.33  ? 8   G   B C6    1 
ATOM   6196 O  O6    . G   B 2 47  ? 149.541 161.432 150.875 1.00 30.52  ? 8   G   B O6    1 
ATOM   6197 N  N1    . G   B 2 47  ? 148.491 160.331 152.560 1.00 35.52  ? 8   G   B N1    1 
ATOM   6198 C  C2    . G   B 2 47  ? 147.421 160.102 153.386 1.00 33.46  ? 8   G   B C2    1 
ATOM   6199 N  N2    . G   B 2 47  ? 147.556 159.122 154.285 1.00 36.96  ? 8   G   B N2    1 
ATOM   6200 N  N3    . G   B 2 47  ? 146.290 160.781 153.345 1.00 33.51  ? 8   G   B N3    1 
ATOM   6201 C  C4    . G   B 2 47  ? 146.304 161.731 152.394 1.00 32.11  ? 8   G   B C4    1 
ATOM   6202 P  P     . G   B 2 48  ? 144.277 166.361 155.981 1.00 67.03  ? 9   G   B P     1 
ATOM   6203 O  OP1   . G   B 2 48  ? 143.348 167.308 156.643 1.00 60.82  ? 9   G   B OP1   1 
ATOM   6204 O  OP2   . G   B 2 48  ? 145.218 166.848 154.943 1.00 46.47  ? 9   G   B OP2   1 
ATOM   6205 O  "O5'" . G   B 2 48  ? 145.133 165.617 157.093 1.00 59.55  ? 9   G   B "O5'" 1 
ATOM   6206 C  "C5'" . G   B 2 48  ? 144.543 164.602 157.886 1.00 50.60  ? 9   G   B "C5'" 1 
ATOM   6207 C  "C4'" . G   B 2 48  ? 145.487 163.451 158.113 1.00 47.20  ? 9   G   B "C4'" 1 
ATOM   6208 O  "O4'" . G   B 2 48  ? 145.804 162.806 156.856 1.00 46.16  ? 9   G   B "O4'" 1 
ATOM   6209 C  "C3'" . G   B 2 48  ? 146.848 163.792 158.686 1.00 45.79  ? 9   G   B "C3'" 1 
ATOM   6210 O  "O3'" . G   B 2 48  ? 146.821 164.041 160.078 1.00 53.22  ? 9   G   B "O3'" 1 
ATOM   6211 C  "C2'" . G   B 2 48  ? 147.668 162.569 158.307 1.00 44.40  ? 9   G   B "C2'" 1 
ATOM   6212 O  "O2'" . G   B 2 48  ? 147.385 161.491 159.185 1.00 47.12  ? 9   G   B "O2'" 1 
ATOM   6213 C  "C1'" . G   B 2 48  ? 147.090 162.231 156.933 1.00 41.51  ? 9   G   B "C1'" 1 
ATOM   6214 N  N9    . G   B 2 48  ? 147.928 162.726 155.824 1.00 35.28  ? 9   G   B N9    1 
ATOM   6215 C  C8    . G   B 2 48  ? 147.665 163.715 154.915 1.00 32.93  ? 9   G   B C8    1 
ATOM   6216 N  N7    . G   B 2 48  ? 148.632 163.892 154.056 1.00 29.77  ? 9   G   B N7    1 
ATOM   6217 C  C5    . G   B 2 48  ? 149.590 162.956 154.414 1.00 33.05  ? 9   G   B C5    1 
ATOM   6218 C  C6    . G   B 2 48  ? 150.862 162.658 153.861 1.00 34.56  ? 9   G   B C6    1 
ATOM   6219 O  O6    . G   B 2 48  ? 151.422 163.177 152.894 1.00 39.34  ? 9   G   B O6    1 
ATOM   6220 N  N1    . G   B 2 48  ? 151.496 161.632 154.543 1.00 34.53  ? 9   G   B N1    1 
ATOM   6221 C  C2    . G   B 2 48  ? 150.975 160.978 155.625 1.00 35.23  ? 9   G   B C2    1 
ATOM   6222 N  N2    . G   B 2 48  ? 151.723 160.013 156.170 1.00 33.91  ? 9   G   B N2    1 
ATOM   6223 N  N3    . G   B 2 48  ? 149.800 161.243 156.149 1.00 35.98  ? 9   G   B N3    1 
ATOM   6224 C  C4    . G   B 2 48  ? 149.164 162.233 155.500 1.00 35.50  ? 9   G   B C4    1 
ATOM   6225 P  P     . U   B 2 49  ? 147.751 165.191 160.698 1.00 61.49  ? 10  U   B P     1 
ATOM   6226 O  OP1   . U   B 2 49  ? 147.325 165.406 162.101 1.00 57.67  ? 10  U   B OP1   1 
ATOM   6227 O  OP2   . U   B 2 49  ? 147.755 166.329 159.751 1.00 56.04  ? 10  U   B OP2   1 
ATOM   6228 O  "O5'" . U   B 2 49  ? 149.206 164.545 160.708 1.00 48.61  ? 10  U   B "O5'" 1 
ATOM   6229 C  "C5'" . U   B 2 49  ? 149.465 163.374 161.464 1.00 44.13  ? 10  U   B "C5'" 1 
ATOM   6230 C  "C4'" . U   B 2 49  ? 150.675 162.625 160.962 1.00 42.57  ? 10  U   B "C4'" 1 
ATOM   6231 O  "O4'" . U   B 2 49  ? 150.551 162.358 159.542 1.00 43.55  ? 10  U   B "O4'" 1 
ATOM   6232 C  "C3'" . U   B 2 49  ? 152.004 163.341 161.078 1.00 40.00  ? 10  U   B "C3'" 1 
ATOM   6233 O  "O3'" . U   B 2 49  ? 152.537 163.310 162.388 1.00 40.77  ? 10  U   B "O3'" 1 
ATOM   6234 C  "C2'" . U   B 2 49  ? 152.854 162.610 160.049 1.00 43.09  ? 10  U   B "C2'" 1 
ATOM   6235 O  "O2'" . U   B 2 49  ? 153.276 161.353 160.554 1.00 49.84  ? 10  U   B "O2'" 1 
ATOM   6236 C  "C1'" . U   B 2 49  ? 151.829 162.353 158.944 1.00 39.26  ? 10  U   B "C1'" 1 
ATOM   6237 N  N1    . U   B 2 49  ? 151.863 163.383 157.880 1.00 37.61  ? 10  U   B N1    1 
ATOM   6238 C  C2    . U   B 2 49  ? 152.963 163.452 157.044 1.00 37.95  ? 10  U   B C2    1 
ATOM   6239 O  O2    . U   B 2 49  ? 153.928 162.717 157.136 1.00 39.02  ? 10  U   B O2    1 
ATOM   6240 N  N3    . U   B 2 49  ? 152.907 164.427 156.085 1.00 35.51  ? 10  U   B N3    1 
ATOM   6241 C  C4    . U   B 2 49  ? 151.887 165.322 155.874 1.00 36.84  ? 10  U   B C4    1 
ATOM   6242 O  O4    . U   B 2 49  ? 151.983 166.149 154.967 1.00 37.96  ? 10  U   B O4    1 
ATOM   6243 C  C5    . U   B 2 49  ? 150.784 165.186 156.771 1.00 38.18  ? 10  U   B C5    1 
ATOM   6244 C  C6    . U   B 2 49  ? 150.810 164.243 157.715 1.00 38.46  ? 10  U   B C6    1 
ATOM   6245 P  P     . G   B 2 50  ? 153.196 164.632 163.016 1.00 49.69  ? 11  G   B P     1 
ATOM   6246 O  OP1   . G   B 2 50  ? 152.953 164.625 164.476 1.00 52.02  ? 11  G   B OP1   1 
ATOM   6247 O  OP2   . G   B 2 50  ? 152.749 165.792 162.213 1.00 46.62  ? 11  G   B OP2   1 
ATOM   6248 O  "O5'" . G   B 2 50  ? 154.753 164.440 162.759 1.00 44.90  ? 11  G   B "O5'" 1 
ATOM   6249 C  "C5'" . G   B 2 50  ? 155.420 163.261 163.181 1.00 45.28  ? 11  G   B "C5'" 1 
ATOM   6250 C  "C4'" . G   B 2 50  ? 156.756 163.108 162.502 1.00 43.72  ? 11  G   B "C4'" 1 
ATOM   6251 O  "O4'" . G   B 2 50  ? 156.561 162.782 161.106 1.00 44.57  ? 11  G   B "O4'" 1 
ATOM   6252 C  "C3'" . G   B 2 50  ? 157.625 164.349 162.473 1.00 40.86  ? 11  G   B "C3'" 1 
ATOM   6253 O  "O3'" . G   B 2 50  ? 158.327 164.548 163.684 1.00 43.81  ? 11  G   B "O3'" 1 
ATOM   6254 C  "C2'" . G   B 2 50  ? 158.527 164.107 161.267 1.00 40.84  ? 11  G   B "C2'" 1 
ATOM   6255 O  "O2'" . G   B 2 50  ? 159.619 163.262 161.597 1.00 40.31  ? 11  G   B "O2'" 1 
ATOM   6256 C  "C1'" . G   B 2 50  ? 157.595 163.345 160.331 1.00 39.51  ? 11  G   B "C1'" 1 
ATOM   6257 N  N9    . G   B 2 50  ? 157.000 164.200 159.290 1.00 40.01  ? 11  G   B N9    1 
ATOM   6258 C  C8    . G   B 2 50  ? 155.737 164.726 159.268 1.00 39.94  ? 11  G   B C8    1 
ATOM   6259 N  N7    . G   B 2 50  ? 155.499 165.426 158.197 1.00 37.75  ? 11  G   B N7    1 
ATOM   6260 C  C5    . G   B 2 50  ? 156.671 165.344 157.466 1.00 37.35  ? 11  G   B C5    1 
ATOM   6261 C  C6    . G   B 2 50  ? 157.008 165.906 156.216 1.00 37.48  ? 11  G   B C6    1 
ATOM   6262 O  O6    . G   B 2 50  ? 156.305 166.602 155.483 1.00 39.21  ? 11  G   B O6    1 
ATOM   6263 N  N1    . G   B 2 50  ? 158.301 165.576 155.839 1.00 38.79  ? 11  G   B N1    1 
ATOM   6264 C  C2    . G   B 2 50  ? 159.163 164.804 156.576 1.00 39.31  ? 11  G   B C2    1 
ATOM   6265 N  N2    . G   B 2 50  ? 160.374 164.592 156.052 1.00 35.74  ? 11  G   B N2    1 
ATOM   6266 N  N3    . G   B 2 50  ? 158.863 164.278 157.748 1.00 38.99  ? 11  G   B N3    1 
ATOM   6267 C  C4    . G   B 2 50  ? 157.608 164.590 158.127 1.00 39.65  ? 11  G   B C4    1 
ATOM   6268 P  P     . C   B 2 51  ? 158.758 166.026 164.128 1.00 54.32  ? 12  C   B P     1 
ATOM   6269 O  OP1   . C   B 2 51  ? 159.254 165.944 165.522 1.00 46.16  ? 12  C   B OP1   1 
ATOM   6270 O  OP2   . C   B 2 51  ? 157.656 166.957 163.795 1.00 37.74  ? 12  C   B OP2   1 
ATOM   6271 O  "O5'" . C   B 2 51  ? 159.991 166.362 163.180 1.00 51.02  ? 12  C   B "O5'" 1 
ATOM   6272 C  "C5'" . C   B 2 51  ? 161.163 165.565 163.195 1.00 39.87  ? 12  C   B "C5'" 1 
ATOM   6273 C  "C4'" . C   B 2 51  ? 162.058 165.886 162.028 1.00 43.76  ? 12  C   B "C4'" 1 
ATOM   6274 O  "O4'" . C   B 2 51  ? 161.407 165.527 160.781 1.00 45.73  ? 12  C   B "O4'" 1 
ATOM   6275 C  "C3'" . C   B 2 51  ? 162.402 167.349 161.839 1.00 46.92  ? 12  C   B "C3'" 1 
ATOM   6276 O  "O3'" . C   B 2 51  ? 163.404 167.812 162.721 1.00 47.53  ? 12  C   B "O3'" 1 
ATOM   6277 C  "C2'" . C   B 2 51  ? 162.800 167.401 160.371 1.00 45.44  ? 12  C   B "C2'" 1 
ATOM   6278 O  "O2'" . C   B 2 51  ? 164.104 166.875 160.185 1.00 41.71  ? 12  C   B "O2'" 1 
ATOM   6279 C  "C1'" . C   B 2 51  ? 161.797 166.427 159.761 1.00 41.68  ? 12  C   B "C1'" 1 
ATOM   6280 N  N1    . C   B 2 51  ? 160.593 167.115 159.234 1.00 37.65  ? 12  C   B N1    1 
ATOM   6281 C  C2    . C   B 2 51  ? 160.640 167.699 157.968 1.00 41.51  ? 12  C   B C2    1 
ATOM   6282 O  O2    . C   B 2 51  ? 161.693 167.629 157.327 1.00 45.16  ? 12  C   B O2    1 
ATOM   6283 N  N3    . C   B 2 51  ? 159.546 168.322 157.475 1.00 39.85  ? 12  C   B N3    1 
ATOM   6284 C  C4    . C   B 2 51  ? 158.431 168.374 158.197 1.00 38.38  ? 12  C   B C4    1 
ATOM   6285 N  N4    . C   B 2 51  ? 157.373 168.997 157.681 1.00 34.32  ? 12  C   B N4    1 
ATOM   6286 C  C5    . C   B 2 51  ? 158.347 167.788 159.489 1.00 38.35  ? 12  C   B C5    1 
ATOM   6287 C  C6    . C   B 2 51  ? 159.440 167.180 159.960 1.00 38.70  ? 12  C   B C6    1 
ATOM   6288 P  P     . G   B 2 52  ? 163.337 169.316 163.269 1.00 56.28  ? 13  G   B P     1 
ATOM   6289 O  OP1   . G   B 2 52  ? 164.149 169.417 164.504 1.00 52.61  ? 13  G   B OP1   1 
ATOM   6290 O  OP2   . G   B 2 52  ? 161.912 169.724 163.278 1.00 49.33  ? 13  G   B OP2   1 
ATOM   6291 O  "O5'" . G   B 2 52  ? 164.061 170.158 162.135 1.00 46.13  ? 13  G   B "O5'" 1 
ATOM   6292 C  "C5'" . G   B 2 52  ? 165.258 169.694 161.543 1.00 44.03  ? 13  G   B "C5'" 1 
ATOM   6293 C  "C4'" . G   B 2 52  ? 165.500 170.368 160.220 1.00 48.58  ? 13  G   B "C4'" 1 
ATOM   6294 O  "O4'" . G   B 2 52  ? 164.617 169.817 159.214 1.00 46.13  ? 13  G   B "O4'" 1 
ATOM   6295 C  "C3'" . G   B 2 52  ? 165.221 171.857 160.175 1.00 50.22  ? 13  G   B "C3'" 1 
ATOM   6296 O  "O3'" . G   B 2 52  ? 166.279 172.626 160.714 1.00 57.55  ? 13  G   B "O3'" 1 
ATOM   6297 C  "C2'" . G   B 2 52  ? 164.984 172.101 158.693 1.00 50.91  ? 13  G   B "C2'" 1 
ATOM   6298 O  "O2'" . G   B 2 52  ? 166.217 172.149 157.996 1.00 59.39  ? 13  G   B "O2'" 1 
ATOM   6299 C  "C1'" . G   B 2 52  ? 164.259 170.820 158.290 1.00 45.21  ? 13  G   B "C1'" 1 
ATOM   6300 N  N9    . G   B 2 52  ? 162.795 170.969 158.310 1.00 46.39  ? 13  G   B N9    1 
ATOM   6301 C  C8    . G   B 2 52  ? 161.941 170.482 159.262 1.00 46.69  ? 13  G   B C8    1 
ATOM   6302 N  N7    . G   B 2 52  ? 160.693 170.752 159.026 1.00 43.60  ? 13  G   B N7    1 
ATOM   6303 C  C5    . G   B 2 52  ? 160.724 171.457 157.838 1.00 43.46  ? 13  G   B C5    1 
ATOM   6304 C  C6    . G   B 2 52  ? 159.666 172.016 157.092 1.00 52.47  ? 13  G   B C6    1 
ATOM   6305 O  O6    . G   B 2 52  ? 158.458 171.987 157.340 1.00 60.50  ? 13  G   B O6    1 
ATOM   6306 N  N1    . G   B 2 52  ? 160.131 172.650 155.949 1.00 54.88  ? 13  G   B N1    1 
ATOM   6307 C  C2    . G   B 2 52  ? 161.442 172.739 155.576 1.00 50.87  ? 13  G   B C2    1 
ATOM   6308 N  N2    . G   B 2 52  ? 161.683 173.400 154.437 1.00 51.06  ? 13  G   B N2    1 
ATOM   6309 N  N3    . G   B 2 52  ? 162.441 172.225 156.268 1.00 50.11  ? 13  G   B N3    1 
ATOM   6310 C  C4    . G   B 2 52  ? 162.011 171.600 157.379 1.00 46.65  ? 13  G   B C4    1 
ATOM   6311 P  P     . C   B 2 53  ? 165.979 174.043 161.400 1.00 67.02  ? 14  C   B P     1 
ATOM   6312 O  OP1   . C   B 2 53  ? 167.228 174.497 162.057 1.00 61.15  ? 14  C   B OP1   1 
ATOM   6313 O  OP2   . C   B 2 53  ? 164.735 173.923 162.194 1.00 62.49  ? 14  C   B OP2   1 
ATOM   6314 O  "O5'" . C   B 2 53  ? 165.689 175.005 160.167 1.00 62.72  ? 14  C   B "O5'" 1 
ATOM   6315 C  "C5'" . C   B 2 53  ? 166.697 175.262 159.201 1.00 62.91  ? 14  C   B "C5'" 1 
ATOM   6316 C  "C4'" . C   B 2 53  ? 166.151 176.020 158.021 1.00 63.26  ? 14  C   B "C4'" 1 
ATOM   6317 O  "O4'" . C   B 2 53  ? 165.138 175.232 157.351 1.00 58.17  ? 14  C   B "O4'" 1 
ATOM   6318 C  "C3'" . C   B 2 53  ? 165.452 177.326 158.343 1.00 66.25  ? 14  C   B "C3'" 1 
ATOM   6319 O  "O3'" . C   B 2 53  ? 166.369 178.389 158.525 1.00 75.65  ? 14  C   B "O3'" 1 
ATOM   6320 C  "C2'" . C   B 2 53  ? 164.533 177.518 157.146 1.00 68.51  ? 14  C   B "C2'" 1 
ATOM   6321 O  "O2'" . C   B 2 53  ? 165.261 178.038 156.045 1.00 74.81  ? 14  C   B "O2'" 1 
ATOM   6322 C  "C1'" . C   B 2 53  ? 164.145 176.076 156.819 1.00 59.19  ? 14  C   B "C1'" 1 
ATOM   6323 N  N1    . C   B 2 53  ? 162.841 175.677 157.391 1.00 58.04  ? 14  C   B N1    1 
ATOM   6324 C  C2    . C   B 2 53  ? 161.654 176.085 156.780 1.00 63.39  ? 14  C   B C2    1 
ATOM   6325 O  O2    . C   B 2 53  ? 161.711 176.804 155.772 1.00 67.22  ? 14  C   B O2    1 
ATOM   6326 N  N3    . C   B 2 53  ? 160.471 175.694 157.309 1.00 62.99  ? 14  C   B N3    1 
ATOM   6327 C  C4    . C   B 2 53  ? 160.448 174.924 158.394 1.00 58.48  ? 14  C   B C4    1 
ATOM   6328 N  N4    . C   B 2 53  ? 159.261 174.561 158.883 1.00 58.94  ? 14  C   B N4    1 
ATOM   6329 C  C5    . C   B 2 53  ? 161.642 174.487 159.029 1.00 56.22  ? 14  C   B C5    1 
ATOM   6330 C  C6    . C   B 2 53  ? 162.803 174.879 158.496 1.00 56.58  ? 14  C   B C6    1 
ATOM   6331 P  P     . G   B 2 54  ? 165.991 179.639 159.455 1.00 90.68  ? 15  G   B P     1 
ATOM   6332 O  OP1   . G   B 2 54  ? 167.163 180.550 159.479 1.00 82.12  ? 15  G   B OP1   1 
ATOM   6333 O  OP2   . G   B 2 54  ? 165.434 179.125 160.731 1.00 80.52  ? 15  G   B OP2   1 
ATOM   6334 O  "O5'" . G   B 2 54  ? 164.824 180.363 158.651 1.00 80.68  ? 15  G   B "O5'" 1 
ATOM   6335 C  "C5'" . G   B 2 54  ? 163.854 181.145 159.326 1.00 81.14  ? 15  G   B "C5'" 1 
ATOM   6336 C  "C4'" . G   B 2 54  ? 162.820 181.680 158.371 1.00 84.31  ? 15  G   B "C4'" 1 
ATOM   6337 O  "O4'" . G   B 2 54  ? 162.226 180.583 157.635 1.00 79.45  ? 15  G   B "O4'" 1 
ATOM   6338 C  "C3'" . G   B 2 54  ? 161.640 182.385 159.018 1.00 88.38  ? 15  G   B "C3'" 1 
ATOM   6339 O  "O3'" . G   B 2 54  ? 161.922 183.738 159.323 1.00 94.05  ? 15  G   B "O3'" 1 
ATOM   6340 C  "C2'" . G   B 2 54  ? 160.532 182.211 157.989 1.00 86.07  ? 15  G   B "C2'" 1 
ATOM   6341 O  "O2'" . G   B 2 54  ? 160.671 183.162 156.943 1.00 82.64  ? 15  G   B "O2'" 1 
ATOM   6342 C  "C1'" . G   B 2 54  ? 160.853 180.828 157.423 1.00 81.11  ? 15  G   B "C1'" 1 
ATOM   6343 N  N9    . G   B 2 54  ? 160.084 179.736 158.054 1.00 72.74  ? 15  G   B N9    1 
ATOM   6344 C  C8    . G   B 2 54  ? 160.620 178.736 158.820 1.00 62.89  ? 15  G   B C8    1 
ATOM   6345 N  N7    . G   B 2 54  ? 159.739 177.880 159.242 1.00 62.68  ? 15  G   B N7    1 
ATOM   6346 C  C5    . G   B 2 54  ? 158.541 178.327 158.711 1.00 71.15  ? 15  G   B C5    1 
ATOM   6347 C  C6    . G   B 2 54  ? 157.229 177.793 158.840 1.00 75.00  ? 15  G   B C6    1 
ATOM   6348 O  O6    . G   B 2 54  ? 156.871 176.781 159.452 1.00 73.91  ? 15  G   B O6    1 
ATOM   6349 N  N1    . G   B 2 54  ? 156.291 178.548 158.147 1.00 77.65  ? 15  G   B N1    1 
ATOM   6350 C  C2    . G   B 2 54  ? 156.588 179.680 157.431 1.00 81.13  ? 15  G   B C2    1 
ATOM   6351 N  N2    . G   B 2 54  ? 155.553 180.282 156.828 1.00 82.28  ? 15  G   B N2    1 
ATOM   6352 N  N3    . G   B 2 54  ? 157.807 180.191 157.307 1.00 82.68  ? 15  G   B N3    1 
ATOM   6353 C  C4    . G   B 2 54  ? 158.736 179.470 157.968 1.00 76.14  ? 15  G   B C4    1 
ATOM   6354 P  P     . U   B 2 55  ? 161.222 184.444 160.581 1.00 112.74 ? 16  U   B P     1 
ATOM   6355 O  OP1   . U   B 2 55  ? 162.033 185.631 160.952 1.00 108.45 ? 16  U   B OP1   1 
ATOM   6356 O  OP2   . U   B 2 55  ? 160.945 183.395 161.592 1.00 100.87 ? 16  U   B OP2   1 
ATOM   6357 O  "O5'" . U   B 2 55  ? 159.827 184.952 160.006 1.00 100.82 ? 16  U   B "O5'" 1 
ATOM   6358 C  "C5'" . U   B 2 55  ? 158.795 185.384 160.878 1.00 93.94  ? 16  U   B "C5'" 1 
ATOM   6359 C  "C4'" . U   B 2 55  ? 157.434 185.149 160.274 1.00 94.07  ? 16  U   B "C4'" 1 
ATOM   6360 O  "O4'" . U   B 2 55  ? 157.391 183.833 159.665 1.00 92.99  ? 16  U   B "O4'" 1 
ATOM   6361 C  "C3'" . U   B 2 55  ? 156.264 185.147 161.246 1.00 89.87  ? 16  U   B "C3'" 1 
ATOM   6362 O  "O3'" . U   B 2 55  ? 155.815 186.449 161.577 1.00 88.60  ? 16  U   B "O3'" 1 
ATOM   6363 C  "C2'" . U   B 2 55  ? 155.221 184.320 160.510 1.00 90.92  ? 16  U   B "C2'" 1 
ATOM   6364 O  "O2'" . U   B 2 55  ? 154.565 185.105 159.524 1.00 77.58  ? 16  U   B "O2'" 1 
ATOM   6365 C  "C1'" . U   B 2 55  ? 156.098 183.283 159.801 1.00 89.42  ? 16  U   B "C1'" 1 
ATOM   6366 N  N1    . U   B 2 55  ? 156.200 182.007 160.549 1.00 80.75  ? 16  U   B N1    1 
ATOM   6367 C  C2    . U   B 2 55  ? 155.066 181.231 160.674 1.00 83.77  ? 16  U   B C2    1 
ATOM   6368 O  O2    . U   B 2 55  ? 153.983 181.545 160.216 1.00 90.66  ? 16  U   B O2    1 
ATOM   6369 N  N3    . U   B 2 55  ? 155.224 180.064 161.368 1.00 79.90  ? 16  U   B N3    1 
ATOM   6370 C  C4    . U   B 2 55  ? 156.378 179.586 161.936 1.00 76.92  ? 16  U   B C4    1 
ATOM   6371 O  O4    . U   B 2 55  ? 156.358 178.508 162.533 1.00 72.80  ? 16  U   B O4    1 
ATOM   6372 C  C5    . U   B 2 55  ? 157.514 180.438 161.760 1.00 78.68  ? 16  U   B C5    1 
ATOM   6373 C  C6    . U   B 2 55  ? 157.391 181.587 161.087 1.00 79.56  ? 16  U   B C6    1 
ATOM   6374 O  "O5'" . DT  C 3 1   ? 157.640 126.808 96.018  1.00 95.37  ? -10 DT  C "O5'" 1 
ATOM   6375 C  "C5'" . DT  C 3 1   ? 158.849 126.446 96.676  1.00 89.20  ? -10 DT  C "C5'" 1 
ATOM   6376 C  "C4'" . DT  C 3 1   ? 158.599 125.353 97.697  1.00 93.07  ? -10 DT  C "C4'" 1 
ATOM   6377 O  "O4'" . DT  C 3 1   ? 159.708 125.293 98.624  1.00 86.55  ? -10 DT  C "O4'" 1 
ATOM   6378 C  "C3'" . DT  C 3 1   ? 157.394 125.576 98.581  1.00 98.24  ? -10 DT  C "C3'" 1 
ATOM   6379 O  "O3'" . DT  C 3 1   ? 157.009 124.340 99.160  1.00 103.19 ? -10 DT  C "O3'" 1 
ATOM   6380 C  "C2'" . DT  C 3 1   ? 157.959 126.537 99.625  1.00 90.94  ? -10 DT  C "C2'" 1 
ATOM   6381 C  "C1'" . DT  C 3 1   ? 159.376 125.994 99.815  1.00 84.64  ? -10 DT  C "C1'" 1 
ATOM   6382 N  N1    . DT  C 3 1   ? 160.408 127.053 100.023 1.00 79.59  ? -10 DT  C N1    1 
ATOM   6383 C  C2    . DT  C 3 1   ? 161.378 126.870 100.983 1.00 70.89  ? -10 DT  C C2    1 
ATOM   6384 O  O2    . DT  C 3 1   ? 161.433 125.886 101.698 1.00 61.42  ? -10 DT  C O2    1 
ATOM   6385 N  N3    . DT  C 3 1   ? 162.287 127.896 101.078 1.00 69.63  ? -10 DT  C N3    1 
ATOM   6386 C  C4    . DT  C 3 1   ? 162.321 129.055 100.328 1.00 66.95  ? -10 DT  C C4    1 
ATOM   6387 O  O4    . DT  C 3 1   ? 163.177 129.917 100.491 1.00 58.83  ? -10 DT  C O4    1 
ATOM   6388 C  C5    . DT  C 3 1   ? 161.280 129.179 99.337  1.00 70.48  ? -10 DT  C C5    1 
ATOM   6389 C  C7    . DT  C 3 1   ? 161.216 130.392 98.462  1.00 52.32  ? -10 DT  C C7    1 
ATOM   6390 C  C6    . DT  C 3 1   ? 160.387 128.184 99.232  1.00 79.49  ? -10 DT  C C6    1 
ATOM   6391 P  P     . DG  C 3 2   ? 155.604 124.196 99.923  1.00 119.36 ? -9  DG  C P     1 
ATOM   6392 O  OP1   . DG  C 3 2   ? 154.909 123.006 99.387  1.00 114.95 ? -9  DG  C OP1   1 
ATOM   6393 O  OP2   . DG  C 3 2   ? 154.935 125.516 99.894  1.00 105.99 ? -9  DG  C OP2   1 
ATOM   6394 O  "O5'" . DG  C 3 2   ? 156.035 123.887 101.428 1.00 101.47 ? -9  DG  C "O5'" 1 
ATOM   6395 C  "C5'" . DG  C 3 2   ? 157.093 122.973 101.685 1.00 94.85  ? -9  DG  C "C5'" 1 
ATOM   6396 C  "C4'" . DG  C 3 2   ? 157.326 122.812 103.177 1.00 91.87  ? -9  DG  C "C4'" 1 
ATOM   6397 O  "O4'" . DG  C 3 2   ? 158.314 123.768 103.627 1.00 88.14  ? -9  DG  C "O4'" 1 
ATOM   6398 C  "C3'" . DG  C 3 2   ? 156.108 123.040 104.055 1.00 94.41  ? -9  DG  C "C3'" 1 
ATOM   6399 O  "O3'" . DG  C 3 2   ? 156.201 122.228 105.213 1.00 97.14  ? -9  DG  C "O3'" 1 
ATOM   6400 C  "C2'" . DG  C 3 2   ? 156.210 124.527 104.394 1.00 85.74  ? -9  DG  C "C2'" 1 
ATOM   6401 C  "C1'" . DG  C 3 2   ? 157.716 124.751 104.453 1.00 79.30  ? -9  DG  C "C1'" 1 
ATOM   6402 N  N9    . DG  C 3 2   ? 158.135 126.054 103.954 1.00 72.31  ? -9  DG  C N9    1 
ATOM   6403 C  C8    . DG  C 3 2   ? 157.558 126.774 102.941 1.00 73.05  ? -9  DG  C C8    1 
ATOM   6404 N  N7    . DG  C 3 2   ? 158.167 127.900 102.692 1.00 65.84  ? -9  DG  C N7    1 
ATOM   6405 C  C5    . DG  C 3 2   ? 159.216 127.926 103.596 1.00 60.15  ? -9  DG  C C5    1 
ATOM   6406 C  C6    . DG  C 3 2   ? 160.216 128.901 103.800 1.00 52.75  ? -9  DG  C C6    1 
ATOM   6407 O  O6    . DG  C 3 2   ? 160.375 129.970 103.200 1.00 49.09  ? -9  DG  C O6    1 
ATOM   6408 N  N1    . DG  C 3 2   ? 161.091 128.535 104.818 1.00 50.71  ? -9  DG  C N1    1 
ATOM   6409 C  C2    . DG  C 3 2   ? 161.003 127.373 105.545 1.00 56.03  ? -9  DG  C C2    1 
ATOM   6410 N  N2    . DG  C 3 2   ? 161.932 127.188 106.487 1.00 56.98  ? -9  DG  C N2    1 
ATOM   6411 N  N3    . DG  C 3 2   ? 160.070 126.451 105.363 1.00 56.70  ? -9  DG  C N3    1 
ATOM   6412 C  C4    . DG  C 3 2   ? 159.214 126.792 104.376 1.00 62.83  ? -9  DG  C C4    1 
ATOM   6413 P  P     . DT  C 3 3   ? 154.964 122.115 106.230 1.00 115.23 ? -8  DT  C P     1 
ATOM   6414 O  OP1   . DT  C 3 3   ? 154.717 120.677 106.468 1.00 108.17 ? -8  DT  C OP1   1 
ATOM   6415 O  OP2   . DT  C 3 3   ? 153.871 122.975 105.725 1.00 102.50 ? -8  DT  C OP2   1 
ATOM   6416 O  "O5'" . DT  C 3 3   ? 155.529 122.767 107.574 1.00 95.46  ? -8  DT  C "O5'" 1 
ATOM   6417 C  "C5'" . DT  C 3 3   ? 156.780 122.333 108.095 1.00 84.86  ? -8  DT  C "C5'" 1 
ATOM   6418 C  "C4'" . DT  C 3 3   ? 157.361 123.364 109.045 1.00 77.90  ? -8  DT  C "C4'" 1 
ATOM   6419 O  "O4'" . DT  C 3 3   ? 157.816 124.520 108.296 1.00 76.06  ? -8  DT  C "O4'" 1 
ATOM   6420 C  "C3'" . DT  C 3 3   ? 156.386 123.900 110.099 1.00 72.93  ? -8  DT  C "C3'" 1 
ATOM   6421 O  "O3'" . DT  C 3 3   ? 157.015 123.907 111.369 1.00 74.18  ? -8  DT  C "O3'" 1 
ATOM   6422 C  "C2'" . DT  C 3 3   ? 156.099 125.319 109.613 1.00 66.62  ? -8  DT  C "C2'" 1 
ATOM   6423 C  "C1'" . DT  C 3 3   ? 157.428 125.678 108.988 1.00 64.36  ? -8  DT  C "C1'" 1 
ATOM   6424 N  N1    . DT  C 3 3   ? 157.364 126.816 108.030 1.00 61.01  ? -8  DT  C N1    1 
ATOM   6425 C  C2    . DT  C 3 3   ? 158.299 127.820 108.117 1.00 53.05  ? -8  DT  C C2    1 
ATOM   6426 O  O2    . DT  C 3 3   ? 159.191 127.833 108.944 1.00 48.22  ? -8  DT  C O2    1 
ATOM   6427 N  N3    . DT  C 3 3   ? 158.148 128.819 107.197 1.00 45.58  ? -8  DT  C N3    1 
ATOM   6428 C  C4    . DT  C 3 3   ? 157.182 128.912 106.220 1.00 46.54  ? -8  DT  C C4    1 
ATOM   6429 O  O4    . DT  C 3 3   ? 157.131 129.849 105.437 1.00 42.65  ? -8  DT  C O4    1 
ATOM   6430 C  C5    . DT  C 3 3   ? 156.234 127.831 106.182 1.00 51.65  ? -8  DT  C C5    1 
ATOM   6431 C  C7    . DT  C 3 3   ? 155.139 127.831 105.161 1.00 46.45  ? -8  DT  C C7    1 
ATOM   6432 C  C6    . DT  C 3 3   ? 156.365 126.846 107.080 1.00 58.03  ? -8  DT  C C6    1 
ATOM   6433 P  P     . DC  C 3 4   ? 156.141 123.932 112.717 1.00 84.92  ? -7  DC  C P     1 
ATOM   6434 O  OP1   . DC  C 3 4   ? 156.344 122.637 113.401 1.00 83.73  ? -7  DC  C OP1   1 
ATOM   6435 O  OP2   . DC  C 3 4   ? 154.766 124.370 112.391 1.00 61.14  ? -7  DC  C OP2   1 
ATOM   6436 O  "O5'" . DC  C 3 4   ? 156.827 125.092 113.576 1.00 74.55  ? -7  DC  C "O5'" 1 
ATOM   6437 C  "C5'" . DC  C 3 4   ? 158.241 125.206 113.605 1.00 66.76  ? -7  DC  C "C5'" 1 
ATOM   6438 C  "C4'" . DC  C 3 4   ? 158.664 126.645 113.834 1.00 60.96  ? -7  DC  C "C4'" 1 
ATOM   6439 O  "O4'" . DC  C 3 4   ? 158.528 127.402 112.597 1.00 60.19  ? -7  DC  C "O4'" 1 
ATOM   6440 C  "C3'" . DC  C 3 4   ? 157.841 127.398 114.881 1.00 56.94  ? -7  DC  C "C3'" 1 
ATOM   6441 O  "O3'" . DC  C 3 4   ? 158.688 128.199 115.685 1.00 58.61  ? -7  DC  C "O3'" 1 
ATOM   6442 C  "C2'" . DC  C 3 4   ? 156.927 128.259 114.031 1.00 52.35  ? -7  DC  C "C2'" 1 
ATOM   6443 C  "C1'" . DC  C 3 4   ? 157.844 128.596 112.874 1.00 48.00  ? -7  DC  C "C1'" 1 
ATOM   6444 N  N1    . DC  C 3 4   ? 157.110 129.044 111.661 1.00 41.92  ? -7  DC  C N1    1 
ATOM   6445 C  C2    . DC  C 3 4   ? 157.506 130.213 111.012 1.00 39.18  ? -7  DC  C C2    1 
ATOM   6446 O  O2    . DC  C 3 4   ? 158.480 130.832 111.449 1.00 38.41  ? -7  DC  C O2    1 
ATOM   6447 N  N3    . DC  C 3 4   ? 156.817 130.624 109.922 1.00 34.30  ? -7  DC  C N3    1 
ATOM   6448 C  C4    . DC  C 3 4   ? 155.768 129.916 109.494 1.00 36.51  ? -7  DC  C C4    1 
ATOM   6449 N  N4    . DC  C 3 4   ? 155.116 130.354 108.415 1.00 34.02  ? -7  DC  C N4    1 
ATOM   6450 C  C5    . DC  C 3 4   ? 155.345 128.727 110.150 1.00 38.47  ? -7  DC  C C5    1 
ATOM   6451 C  C6    . DC  C 3 4   ? 156.033 128.336 111.223 1.00 43.98  ? -7  DC  C C6    1 
ATOM   6452 P  P     . DT  C 3 5   ? 158.137 128.834 117.052 1.00 63.53  ? -6  DT  C P     1 
ATOM   6453 O  OP1   . DT  C 3 5   ? 158.971 128.295 118.144 1.00 45.89  ? -6  DT  C OP1   1 
ATOM   6454 O  OP2   . DT  C 3 5   ? 156.672 128.654 117.100 1.00 51.22  ? -6  DT  C OP2   1 
ATOM   6455 O  "O5'" . DT  C 3 5   ? 158.429 130.394 116.892 1.00 50.37  ? -6  DT  C "O5'" 1 
ATOM   6456 C  "C5'" . DT  C 3 5   ? 159.750 130.845 116.676 1.00 43.62  ? -6  DT  C "C5'" 1 
ATOM   6457 C  "C4'" . DT  C 3 5   ? 159.760 132.265 116.137 1.00 40.08  ? -6  DT  C "C4'" 1 
ATOM   6458 O  "O4'" . DT  C 3 5   ? 159.072 132.313 114.862 1.00 39.90  ? -6  DT  C "O4'" 1 
ATOM   6459 C  "C3'" . DT  C 3 5   ? 159.082 133.305 117.029 1.00 37.42  ? -6  DT  C "C3'" 1 
ATOM   6460 O  "O3'" . DT  C 3 5   ? 159.933 134.432 117.180 1.00 39.69  ? -6  DT  C "O3'" 1 
ATOM   6461 C  "C2'" . DT  C 3 5   ? 157.811 133.661 116.260 1.00 32.61  ? -6  DT  C "C2'" 1 
ATOM   6462 C  "C1'" . DT  C 3 5   ? 158.249 133.449 114.827 1.00 31.39  ? -6  DT  C "C1'" 1 
ATOM   6463 N  N1    . DT  C 3 5   ? 157.118 133.182 113.903 1.00 32.00  ? -6  DT  C N1    1 
ATOM   6464 C  C2    . DT  C 3 5   ? 156.890 134.034 112.851 1.00 29.03  ? -6  DT  C C2    1 
ATOM   6465 O  O2    . DT  C 3 5   ? 157.576 135.009 112.621 1.00 24.78  ? -6  DT  C O2    1 
ATOM   6466 N  N3    . DT  C 3 5   ? 155.820 133.693 112.070 1.00 23.61  ? -6  DT  C N3    1 
ATOM   6467 C  C4    . DT  C 3 5   ? 154.977 132.624 112.233 1.00 25.16  ? -6  DT  C C4    1 
ATOM   6468 O  O4    . DT  C 3 5   ? 154.043 132.405 111.477 1.00 27.03  ? -6  DT  C O4    1 
ATOM   6469 C  C5    . DT  C 3 5   ? 155.267 131.776 113.353 1.00 26.72  ? -6  DT  C C5    1 
ATOM   6470 C  C7    . DT  C 3 5   ? 154.412 130.581 113.626 1.00 30.81  ? -6  DT  C C7    1 
ATOM   6471 C  C6    . DT  C 3 5   ? 156.308 132.091 114.128 1.00 30.79  ? -6  DT  C C6    1 
ATOM   6472 P  P     . DA  C 3 6   ? 159.527 135.631 118.164 1.00 50.18  ? -5  DA  C P     1 
ATOM   6473 O  OP1   . DA  C 3 6   ? 160.722 136.018 118.938 1.00 41.34  ? -5  DA  C OP1   1 
ATOM   6474 O  OP2   . DA  C 3 6   ? 158.289 135.244 118.867 1.00 42.29  ? -5  DA  C OP2   1 
ATOM   6475 O  "O5'" . DA  C 3 6   ? 159.170 136.824 117.172 1.00 34.71  ? -5  DA  C "O5'" 1 
ATOM   6476 C  "C5'" . DA  C 3 6   ? 160.107 137.238 116.201 1.00 28.11  ? -5  DA  C "C5'" 1 
ATOM   6477 C  "C4'" . DA  C 3 6   ? 159.520 138.307 115.300 1.00 25.94  ? -5  DA  C "C4'" 1 
ATOM   6478 O  "O4'" . DA  C 3 6   ? 158.479 137.733 114.471 1.00 31.38  ? -5  DA  C "O4'" 1 
ATOM   6479 C  "C3'" . DA  C 3 6   ? 158.875 139.482 116.021 1.00 26.19  ? -5  DA  C "C3'" 1 
ATOM   6480 O  "O3'" . DA  C 3 6   ? 159.127 140.665 115.293 1.00 26.17  ? -5  DA  C "O3'" 1 
ATOM   6481 C  "C2'" . DA  C 3 6   ? 157.396 139.116 115.994 1.00 25.72  ? -5  DA  C "C2'" 1 
ATOM   6482 C  "C1'" . DA  C 3 6   ? 157.284 138.459 114.637 1.00 23.10  ? -5  DA  C "C1'" 1 
ATOM   6483 N  N9    . DA  C 3 6   ? 156.169 137.530 114.519 1.00 20.81  ? -5  DA  C N9    1 
ATOM   6484 C  C8    . DA  C 3 6   ? 155.886 136.481 115.337 1.00 25.76  ? -5  DA  C C8    1 
ATOM   6485 N  N7    . DA  C 3 6   ? 154.823 135.803 114.979 1.00 23.05  ? -5  DA  C N7    1 
ATOM   6486 C  C5    . DA  C 3 6   ? 154.386 136.451 113.842 1.00 20.74  ? -5  DA  C C5    1 
ATOM   6487 C  C6    . DA  C 3 6   ? 153.301 136.223 112.981 1.00 18.93  ? -5  DA  C C6    1 
ATOM   6488 N  N6    . DA  C 3 6   ? 152.429 135.229 113.145 1.00 21.24  ? -5  DA  C N6    1 
ATOM   6489 N  N1    . DA  C 3 6   ? 153.147 137.056 111.939 1.00 19.58  ? -5  DA  C N1    1 
ATOM   6490 C  C2    . DA  C 3 6   ? 154.022 138.052 111.779 1.00 21.14  ? -5  DA  C C2    1 
ATOM   6491 N  N3    . DA  C 3 6   ? 155.082 138.362 112.515 1.00 20.56  ? -5  DA  C N3    1 
ATOM   6492 C  C4    . DA  C 3 6   ? 155.207 137.517 113.543 1.00 22.46  ? -5  DA  C C4    1 
ATOM   6493 P  P     . DT  C 3 7   ? 158.753 142.099 115.899 1.00 37.38  ? -4  DT  C P     1 
ATOM   6494 O  OP1   . DT  C 3 7   ? 159.951 142.952 115.803 1.00 35.13  ? -4  DT  C OP1   1 
ATOM   6495 O  OP2   . DT  C 3 7   ? 158.104 141.889 117.204 1.00 30.02  ? -4  DT  C OP2   1 
ATOM   6496 O  "O5'" . DT  C 3 7   ? 157.652 142.651 114.889 1.00 34.97  ? -4  DT  C "O5'" 1 
ATOM   6497 C  "C5'" . DT  C 3 7   ? 157.884 142.587 113.499 1.00 27.55  ? -4  DT  C "C5'" 1 
ATOM   6498 C  "C4'" . DT  C 3 7   ? 156.636 142.941 112.714 1.00 29.05  ? -4  DT  C "C4'" 1 
ATOM   6499 O  "O4'" . DT  C 3 7   ? 155.690 141.847 112.754 1.00 27.97  ? -4  DT  C "O4'" 1 
ATOM   6500 C  "C3'" . DT  C 3 7   ? 155.868 144.164 113.199 1.00 26.87  ? -4  DT  C "C3'" 1 
ATOM   6501 O  "O3'" . DT  C 3 7   ? 155.400 144.868 112.063 1.00 29.95  ? -4  DT  C "O3'" 1 
ATOM   6502 C  "C2'" . DT  C 3 7   ? 154.716 143.537 113.978 1.00 21.15  ? -4  DT  C "C2'" 1 
ATOM   6503 C  "C1'" . DT  C 3 7   ? 154.423 142.353 113.092 1.00 20.24  ? -4  DT  C "C1'" 1 
ATOM   6504 N  N1    . DT  C 3 7   ? 153.654 141.259 113.726 1.00 16.75  ? -4  DT  C N1    1 
ATOM   6505 C  C2    . DT  C 3 7   ? 152.569 140.756 113.070 1.00 19.46  ? -4  DT  C C2    1 
ATOM   6506 O  O2    . DT  C 3 7   ? 152.178 141.191 112.007 1.00 21.49  ? -4  DT  C O2    1 
ATOM   6507 N  N3    . DT  C 3 7   ? 151.944 139.724 113.706 1.00 18.63  ? -4  DT  C N3    1 
ATOM   6508 C  C4    . DT  C 3 7   ? 152.297 139.152 114.905 1.00 20.79  ? -4  DT  C C4    1 
ATOM   6509 O  O4    . DT  C 3 7   ? 151.669 138.221 115.397 1.00 22.69  ? -4  DT  C O4    1 
ATOM   6510 C  C5    . DT  C 3 7   ? 153.457 139.716 115.535 1.00 17.13  ? -4  DT  C C5    1 
ATOM   6511 C  C7    . DT  C 3 7   ? 153.934 139.173 116.843 1.00 17.19  ? -4  DT  C C7    1 
ATOM   6512 C  C6    . DT  C 3 7   ? 154.078 140.728 114.920 1.00 17.48  ? -4  DT  C C6    1 
ATOM   6513 P  P     . DT  C 3 8   ? 154.884 146.380 112.175 1.00 47.98  ? -3  DT  C P     1 
ATOM   6514 O  OP1   . DT  C 3 8   ? 155.668 147.178 111.213 1.00 26.08  ? -3  DT  C OP1   1 
ATOM   6515 O  OP2   . DT  C 3 8   ? 154.871 146.759 113.600 1.00 43.25  ? -3  DT  C OP2   1 
ATOM   6516 O  "O5'" . DT  C 3 8   ? 153.372 146.290 111.662 1.00 37.97  ? -3  DT  C "O5'" 1 
ATOM   6517 C  "C5'" . DT  C 3 8   ? 153.079 145.578 110.475 1.00 23.63  ? -3  DT  C "C5'" 1 
ATOM   6518 C  "C4'" . DT  C 3 8   ? 151.582 145.406 110.278 1.00 28.08  ? -3  DT  C "C4'" 1 
ATOM   6519 O  "O4'" . DT  C 3 8   ? 151.102 144.253 111.008 1.00 26.86  ? -3  DT  C "O4'" 1 
ATOM   6520 C  "C3'" . DT  C 3 8   ? 150.702 146.566 110.729 1.00 26.88  ? -3  DT  C "C3'" 1 
ATOM   6521 O  "O3'" . DT  C 3 8   ? 149.638 146.678 109.820 1.00 36.29  ? -3  DT  C "O3'" 1 
ATOM   6522 C  "C2'" . DT  C 3 8   ? 150.195 146.078 112.080 1.00 20.51  ? -3  DT  C "C2'" 1 
ATOM   6523 C  "C1'" . DT  C 3 8   ? 149.969 144.623 111.756 1.00 17.58  ? -3  DT  C "C1'" 1 
ATOM   6524 N  N1    . DT  C 3 8   ? 149.893 143.722 112.920 1.00 15.58  ? -3  DT  C N1    1 
ATOM   6525 C  C2    . DT  C 3 8   ? 148.947 142.737 112.926 1.00 16.37  ? -3  DT  C C2    1 
ATOM   6526 O  O2    . DT  C 3 8   ? 148.135 142.592 112.040 1.00 19.23  ? -3  DT  C O2    1 
ATOM   6527 N  N3    . DT  C 3 8   ? 148.970 141.929 114.018 1.00 15.90  ? -3  DT  C N3    1 
ATOM   6528 C  C4    . DT  C 3 8   ? 149.839 141.999 115.084 1.00 17.79  ? -3  DT  C C4    1 
ATOM   6529 O  O4    . DT  C 3 8   ? 149.779 141.217 116.025 1.00 20.41  ? -3  DT  C O4    1 
ATOM   6530 C  C5    . DT  C 3 8   ? 150.818 143.051 115.009 1.00 14.34  ? -3  DT  C C5    1 
ATOM   6531 C  C7    . DT  C 3 8   ? 151.816 143.227 116.104 1.00 17.01  ? -3  DT  C C7    1 
ATOM   6532 C  C6    . DT  C 3 8   ? 150.804 143.846 113.938 1.00 15.48  ? -3  DT  C C6    1 
ATOM   6533 P  P     . DT  C 3 9   ? 149.135 148.102 109.289 1.00 48.51  ? -2  DT  C P     1 
ATOM   6534 O  OP1   . DT  C 3 9   ? 149.402 148.127 107.838 1.00 40.50  ? -2  DT  C OP1   1 
ATOM   6535 O  OP2   . DT  C 3 9   ? 149.697 149.168 110.138 1.00 34.09  ? -2  DT  C OP2   1 
ATOM   6536 O  "O5'" . DT  C 3 9   ? 147.562 148.016 109.530 1.00 35.96  ? -2  DT  C "O5'" 1 
ATOM   6537 C  "C5'" . DT  C 3 9   ? 146.874 146.836 109.153 1.00 30.11  ? -2  DT  C "C5'" 1 
ATOM   6538 C  "C4'" . DT  C 3 9   ? 145.683 146.572 110.053 1.00 32.28  ? -2  DT  C "C4'" 1 
ATOM   6539 O  "O4'" . DT  C 3 9   ? 146.056 145.683 111.135 1.00 32.77  ? -2  DT  C "O4'" 1 
ATOM   6540 C  "C3'" . DT  C 3 9   ? 145.069 147.806 110.716 1.00 34.75  ? -2  DT  C "C3'" 1 
ATOM   6541 O  "O3'" . DT  C 3 9   ? 143.673 147.792 110.522 1.00 39.22  ? -2  DT  C "O3'" 1 
ATOM   6542 C  "C2'" . DT  C 3 9   ? 145.417 147.619 112.193 1.00 32.08  ? -2  DT  C "C2'" 1 
ATOM   6543 C  "C1'" . DT  C 3 9   ? 145.400 146.114 112.298 1.00 23.77  ? -2  DT  C "C1'" 1 
ATOM   6544 N  N1    . DT  C 3 9   ? 146.113 145.585 113.484 1.00 17.74  ? -2  DT  C N1    1 
ATOM   6545 C  C2    . DT  C 3 9   ? 145.645 144.447 114.091 1.00 18.26  ? -2  DT  C C2    1 
ATOM   6546 O  O2    . DT  C 3 9   ? 144.672 143.837 113.702 1.00 18.44  ? -2  DT  C O2    1 
ATOM   6547 N  N3    . DT  C 3 9   ? 146.365 144.044 115.174 1.00 15.06  ? -2  DT  C N3    1 
ATOM   6548 C  C4    . DT  C 3 9   ? 147.478 144.652 115.706 1.00 13.50  ? -2  DT  C C4    1 
ATOM   6549 O  O4    . DT  C 3 9   ? 148.055 144.212 116.685 1.00 14.67  ? -2  DT  C O4    1 
ATOM   6550 C  C5    . DT  C 3 9   ? 147.917 145.840 115.027 1.00 14.51  ? -2  DT  C C5    1 
ATOM   6551 C  C7    . DT  C 3 9   ? 149.118 146.582 115.517 1.00 13.91  ? -2  DT  C C7    1 
ATOM   6552 C  C6    . DT  C 3 9   ? 147.220 146.247 113.960 1.00 15.80  ? -2  DT  C C6    1 
ATOM   6553 P  P     . DA  C 3 10  ? 142.848 149.162 110.456 1.00 45.52  ? -1  DA  C P     1 
ATOM   6554 O  OP1   . DA  C 3 10  ? 142.502 149.407 109.044 1.00 40.03  ? -1  DA  C OP1   1 
ATOM   6555 O  OP2   . DA  C 3 10  ? 143.581 150.176 111.236 1.00 44.76  ? -1  DA  C OP2   1 
ATOM   6556 O  "O5'" . DA  C 3 10  ? 141.506 148.822 111.234 1.00 39.35  ? -1  DA  C "O5'" 1 
ATOM   6557 C  "C5'" . DA  C 3 10  ? 140.825 147.624 110.948 1.00 32.48  ? -1  DA  C "C5'" 1 
ATOM   6558 C  "C4'" . DA  C 3 10  ? 140.432 146.921 112.226 1.00 34.35  ? -1  DA  C "C4'" 1 
ATOM   6559 O  "O4'" . DA  C 3 10  ? 141.616 146.574 112.959 1.00 33.38  ? -1  DA  C "O4'" 1 
ATOM   6560 C  "C3'" . DA  C 3 10  ? 139.595 147.763 113.194 1.00 45.25  ? -1  DA  C "C3'" 1 
ATOM   6561 O  "O3'" . DA  C 3 10  ? 138.234 147.338 113.175 1.00 48.82  ? -1  DA  C "O3'" 1 
ATOM   6562 C  "C2'" . DA  C 3 10  ? 140.238 147.515 114.570 1.00 31.04  ? -1  DA  C "C2'" 1 
ATOM   6563 C  "C1'" . DA  C 3 10  ? 141.237 146.401 114.289 1.00 30.93  ? -1  DA  C "C1'" 1 
ATOM   6564 N  N9    . DA  C 3 10  ? 142.416 146.448 115.150 1.00 25.57  ? -1  DA  C N9    1 
ATOM   6565 C  C8    . DA  C 3 10  ? 143.423 147.367 115.134 1.00 20.65  ? -1  DA  C C8    1 
ATOM   6566 N  N7    . DA  C 3 10  ? 144.342 147.156 116.043 1.00 18.44  ? -1  DA  C N7    1 
ATOM   6567 C  C5    . DA  C 3 10  ? 143.904 146.022 116.699 1.00 17.89  ? -1  DA  C C5    1 
ATOM   6568 C  C6    . DA  C 3 10  ? 144.430 145.280 117.769 1.00 18.30  ? -1  DA  C C6    1 
ATOM   6569 N  N6    . DA  C 3 10  ? 145.569 145.587 118.393 1.00 14.51  ? -1  DA  C N6    1 
ATOM   6570 N  N1    . DA  C 3 10  ? 143.734 144.206 118.181 1.00 20.01  ? -1  DA  C N1    1 
ATOM   6571 C  C2    . DA  C 3 10  ? 142.596 143.897 117.558 1.00 19.25  ? -1  DA  C C2    1 
ATOM   6572 N  N3    . DA  C 3 10  ? 142.007 144.514 116.547 1.00 18.08  ? -1  DA  C N3    1 
ATOM   6573 C  C4    . DA  C 3 10  ? 142.717 145.579 116.162 1.00 19.99  ? -1  DA  C C4    1 
ATOM   6574 P  P     . DG  C 3 11  ? 137.061 148.340 112.718 1.00 56.10  ? 0   DG  C P     1 
ATOM   6575 O  OP1   . DG  C 3 11  ? 135.854 147.974 113.484 1.00 49.50  ? 0   DG  C OP1   1 
ATOM   6576 O  OP2   . DG  C 3 11  ? 137.023 148.339 111.241 1.00 50.98  ? 0   DG  C OP2   1 
ATOM   6577 O  "O5'" . DG  C 3 11  ? 137.544 149.787 113.206 1.00 58.32  ? 0   DG  C "O5'" 1 
ATOM   6578 C  "C5'" . DG  C 3 11  ? 137.329 150.195 114.557 1.00 60.21  ? 0   DG  C "C5'" 1 
ATOM   6579 C  "C4'" . DG  C 3 11  ? 136.600 151.531 114.636 1.00 64.28  ? 0   DG  C "C4'" 1 
ATOM   6580 O  "O4'" . DG  C 3 11  ? 136.938 152.350 113.490 1.00 59.89  ? 0   DG  C "O4'" 1 
ATOM   6581 C  "C3'" . DG  C 3 11  ? 135.083 151.443 114.628 1.00 68.70  ? 0   DG  C "C3'" 1 
ATOM   6582 O  "O3'" . DG  C 3 11  ? 134.544 152.560 115.307 1.00 73.74  ? 0   DG  C "O3'" 1 
ATOM   6583 C  "C2'" . DG  C 3 11  ? 134.778 151.507 113.141 1.00 64.67  ? 0   DG  C "C2'" 1 
ATOM   6584 C  "C1'" . DG  C 3 11  ? 135.791 152.544 112.684 1.00 58.08  ? 0   DG  C "C1'" 1 
ATOM   6585 N  N9    . DG  C 3 11  ? 136.198 152.390 111.301 1.00 55.21  ? 0   DG  C N9    1 
ATOM   6586 C  C8    . DG  C 3 11  ? 136.343 151.218 110.607 1.00 56.32  ? 0   DG  C C8    1 
ATOM   6587 N  N7    . DG  C 3 11  ? 136.747 151.387 109.383 1.00 49.16  ? 0   DG  C N7    1 
ATOM   6588 C  C5    . DG  C 3 11  ? 136.884 152.760 109.261 1.00 60.80  ? 0   DG  C C5    1 
ATOM   6589 C  C6    . DG  C 3 11  ? 137.293 153.539 108.157 1.00 65.20  ? 0   DG  C C6    1 
ATOM   6590 O  O6    . DG  C 3 11  ? 137.626 153.154 107.027 1.00 61.59  ? 0   DG  C O6    1 
ATOM   6591 N  N1    . DG  C 3 11  ? 137.292 154.897 108.459 1.00 65.17  ? 0   DG  C N1    1 
ATOM   6592 C  C2    . DG  C 3 11  ? 136.941 155.431 109.674 1.00 62.30  ? 0   DG  C C2    1 
ATOM   6593 N  N2    . DG  C 3 11  ? 137.005 156.765 109.777 1.00 55.74  ? 0   DG  C N2    1 
ATOM   6594 N  N3    . DG  C 3 11  ? 136.557 154.711 110.716 1.00 58.20  ? 0   DG  C N3    1 
ATOM   6595 C  C4    . DG  C 3 11  ? 136.553 153.389 110.437 1.00 58.33  ? 0   DG  C C4    1 
ATOM   6596 P  P     . DG  C 3 12  ? 133.150 152.440 116.091 1.00 82.02  ? 1   DG  C P     1 
ATOM   6597 O  OP1   . DG  C 3 12  ? 133.389 151.653 117.318 1.00 69.51  ? 1   DG  C OP1   1 
ATOM   6598 O  OP2   . DG  C 3 12  ? 132.125 151.992 115.129 1.00 76.95  ? 1   DG  C OP2   1 
ATOM   6599 O  "O5'" . DG  C 3 12  ? 132.817 153.950 116.500 1.00 83.94  ? 1   DG  C "O5'" 1 
ATOM   6600 C  "C5'" . DG  C 3 12  ? 133.481 155.031 115.848 1.00 79.84  ? 1   DG  C "C5'" 1 
ATOM   6601 C  "C4'" . DG  C 3 12  ? 132.605 155.645 114.766 1.00 85.54  ? 1   DG  C "C4'" 1 
ATOM   6602 O  "O4'" . DG  C 3 12  ? 132.914 155.048 113.485 1.00 83.08  ? 1   DG  C "O4'" 1 
ATOM   6603 C  "C3'" . DG  C 3 12  ? 131.096 155.486 114.973 1.00 93.28  ? 1   DG  C "C3'" 1 
ATOM   6604 O  "O3'" . DG  C 3 12  ? 130.471 156.770 114.949 1.00 103.61 ? 1   DG  C "O3'" 1 
ATOM   6605 C  "C2'" . DG  C 3 12  ? 130.643 154.598 113.804 1.00 88.43  ? 1   DG  C "C2'" 1 
ATOM   6606 C  "C1'" . DG  C 3 12  ? 131.728 154.819 112.763 1.00 81.08  ? 1   DG  C "C1'" 1 
ATOM   6607 N  N9    . DG  C 3 12  ? 131.947 153.659 111.906 1.00 77.18  ? 1   DG  C N9    1 
ATOM   6608 C  C8    . DG  C 3 12  ? 131.653 152.351 112.199 1.00 77.23  ? 1   DG  C C8    1 
ATOM   6609 N  N7    . DG  C 3 12  ? 131.973 151.518 111.250 1.00 74.24  ? 1   DG  C N7    1 
ATOM   6610 C  C5    . DG  C 3 12  ? 132.516 152.325 110.262 1.00 76.33  ? 1   DG  C C5    1 
ATOM   6611 C  C6    . DG  C 3 12  ? 133.036 151.981 108.997 1.00 72.66  ? 1   DG  C C6    1 
ATOM   6612 O  O6    . DG  C 3 12  ? 133.123 150.858 108.485 1.00 68.52  ? 1   DG  C O6    1 
ATOM   6613 N  N1    . DG  C 3 12  ? 133.490 153.101 108.305 1.00 72.57  ? 1   DG  C N1    1 
ATOM   6614 C  C2    . DG  C 3 12  ? 133.443 154.389 108.779 1.00 70.32  ? 1   DG  C C2    1 
ATOM   6615 N  N2    . DG  C 3 12  ? 133.926 155.337 107.966 1.00 65.10  ? 1   DG  C N2    1 
ATOM   6616 N  N3    . DG  C 3 12  ? 132.955 154.727 109.964 1.00 69.77  ? 1   DG  C N3    1 
ATOM   6617 C  C4    . DG  C 3 12  ? 132.511 153.647 110.650 1.00 76.54  ? 1   DG  C C4    1 
ATOM   6618 P  P     . DA  C 3 13  ? 128.871 156.913 114.903 1.00 113.60 ? 2   DA  C P     1 
ATOM   6619 O  OP1   . DA  C 3 13  ? 128.536 158.187 115.572 1.00 104.25 ? 2   DA  C OP1   1 
ATOM   6620 O  OP2   . DA  C 3 13  ? 128.263 155.661 115.404 1.00 107.30 ? 2   DA  C OP2   1 
ATOM   6621 O  "O5'" . DA  C 3 13  ? 128.552 157.066 113.343 1.00 98.90  ? 2   DA  C "O5'" 1 
ATOM   6622 C  "C5'" . DA  C 3 13  ? 129.166 158.115 112.598 1.00 94.73  ? 2   DA  C "C5'" 1 
ATOM   6623 C  "C4'" . DA  C 3 13  ? 129.160 157.809 111.112 1.00 98.51  ? 2   DA  C "C4'" 1 
ATOM   6624 O  "O4'" . DA  C 3 13  ? 129.622 156.469 110.905 1.00 98.57  ? 2   DA  C "O4'" 1 
ATOM   6625 C  "C3'" . DA  C 3 13  ? 127.792 157.855 110.452 1.00 101.36 ? 2   DA  C "C3'" 1 
ATOM   6626 O  "O3'" . DA  C 3 13  ? 127.561 159.149 109.907 1.00 100.67 ? 2   DA  C "O3'" 1 
ATOM   6627 C  "C2'" . DA  C 3 13  ? 127.871 156.786 109.347 1.00 95.94  ? 2   DA  C "C2'" 1 
ATOM   6628 C  "C1'" . DA  C 3 13  ? 129.166 156.023 109.653 1.00 96.80  ? 2   DA  C "C1'" 1 
ATOM   6629 N  N9    . DA  C 3 13  ? 128.993 154.576 109.720 1.00 89.18  ? 2   DA  C N9    1 
ATOM   6630 C  C8    . DA  C 3 13  ? 128.393 153.862 110.721 1.00 87.18  ? 2   DA  C C8    1 
ATOM   6631 N  N7    . DA  C 3 13  ? 128.386 152.568 110.517 1.00 85.53  ? 2   DA  C N7    1 
ATOM   6632 C  C5    . DA  C 3 13  ? 129.028 152.421 109.299 1.00 85.86  ? 2   DA  C C5    1 
ATOM   6633 C  C6    . DA  C 3 13  ? 129.343 151.290 108.522 1.00 82.40  ? 2   DA  C C6    1 
ATOM   6634 N  N6    . DA  C 3 13  ? 129.036 150.041 108.885 1.00 73.56  ? 2   DA  C N6    1 
ATOM   6635 N  N1    . DA  C 3 13  ? 129.990 151.493 107.356 1.00 79.61  ? 2   DA  C N1    1 
ATOM   6636 C  C2    . DA  C 3 13  ? 130.296 152.747 106.997 1.00 75.70  ? 2   DA  C C2    1 
ATOM   6637 N  N3    . DA  C 3 13  ? 130.050 153.886 107.641 1.00 78.10  ? 2   DA  C N3    1 
ATOM   6638 C  C4    . DA  C 3 13  ? 129.410 153.651 108.795 1.00 84.49  ? 2   DA  C C4    1 
ATOM   6639 P  P     . DA  D 4 14  ? 145.169 171.964 162.453 1.00 124.04 ? 4   DA  D P     1 
ATOM   6640 O  OP1   . DA  D 4 14  ? 144.606 170.946 161.536 1.00 123.20 ? 4   DA  D OP1   1 
ATOM   6641 O  OP2   . DA  D 4 14  ? 146.145 171.569 163.492 1.00 109.43 ? 4   DA  D OP2   1 
ATOM   6642 O  "O5'" . DA  D 4 14  ? 145.819 173.146 161.595 1.00 103.47 ? 4   DA  D "O5'" 1 
ATOM   6643 C  "C5'" . DA  D 4 14  ? 146.626 174.120 162.235 1.00 96.35  ? 4   DA  D "C5'" 1 
ATOM   6644 C  "C4'" . DA  D 4 14  ? 146.477 175.474 161.567 1.00 97.22  ? 4   DA  D "C4'" 1 
ATOM   6645 O  "O4'" . DA  D 4 14  ? 147.016 176.494 162.443 1.00 94.48  ? 4   DA  D "O4'" 1 
ATOM   6646 C  "C3'" . DA  D 4 14  ? 147.217 175.623 160.241 1.00 94.62  ? 4   DA  D "C3'" 1 
ATOM   6647 O  "O3'" . DA  D 4 14  ? 146.332 175.374 159.159 1.00 94.91  ? 4   DA  D "O3'" 1 
ATOM   6648 C  "C2'" . DA  D 4 14  ? 147.669 177.079 160.262 1.00 90.06  ? 4   DA  D "C2'" 1 
ATOM   6649 C  "C1'" . DA  D 4 14  ? 147.935 177.304 161.741 1.00 88.74  ? 4   DA  D "C1'" 1 
ATOM   6650 N  N9    . DA  D 4 14  ? 149.289 176.949 162.161 1.00 85.36  ? 4   DA  D N9    1 
ATOM   6651 C  C8    . DA  D 4 14  ? 149.685 175.816 162.815 1.00 83.46  ? 4   DA  D C8    1 
ATOM   6652 N  N7    . DA  D 4 14  ? 150.970 175.771 163.066 1.00 80.43  ? 4   DA  D N7    1 
ATOM   6653 C  C5    . DA  D 4 14  ? 151.451 176.956 162.542 1.00 81.81  ? 4   DA  D C5    1 
ATOM   6654 C  C6    . DA  D 4 14  ? 152.742 177.517 162.484 1.00 78.42  ? 4   DA  D C6    1 
ATOM   6655 N  N6    . DA  D 4 14  ? 153.828 176.922 162.983 1.00 69.29  ? 4   DA  D N6    1 
ATOM   6656 N  N1    . DA  D 4 14  ? 152.873 178.719 161.891 1.00 82.04  ? 4   DA  D N1    1 
ATOM   6657 C  C2    . DA  D 4 14  ? 151.785 179.313 161.392 1.00 84.88  ? 4   DA  D C2    1 
ATOM   6658 N  N3    . DA  D 4 14  ? 150.526 178.888 161.385 1.00 85.26  ? 4   DA  D N3    1 
ATOM   6659 C  C4    . DA  D 4 14  ? 150.426 177.693 161.981 1.00 85.29  ? 4   DA  D C4    1 
ATOM   6660 P  P     . DC  D 4 15  ? 146.893 174.786 157.773 1.00 98.59  ? 5   DC  D P     1 
ATOM   6661 O  OP1   . DC  D 4 15  ? 145.734 174.602 156.877 1.00 91.98  ? 5   DC  D OP1   1 
ATOM   6662 O  OP2   . DC  D 4 15  ? 147.759 173.633 158.091 1.00 94.78  ? 5   DC  D OP2   1 
ATOM   6663 O  "O5'" . DC  D 4 15  ? 147.783 175.974 157.176 1.00 98.00  ? 5   DC  D "O5'" 1 
ATOM   6664 C  "C5'" . DC  D 4 15  ? 147.154 177.168 156.730 1.00 92.72  ? 5   DC  D "C5'" 1 
ATOM   6665 C  "C4'" . DC  D 4 15  ? 148.173 178.239 156.384 1.00 89.02  ? 5   DC  D "C4'" 1 
ATOM   6666 O  "O4'" . DC  D 4 15  ? 148.935 178.596 157.560 1.00 89.36  ? 5   DC  D "O4'" 1 
ATOM   6667 C  "C3'" . DC  D 4 15  ? 149.229 177.830 155.383 1.00 90.06  ? 5   DC  D "C3'" 1 
ATOM   6668 O  "O3'" . DC  D 4 15  ? 148.717 177.910 154.065 1.00 97.42  ? 5   DC  D "O3'" 1 
ATOM   6669 C  "C2'" . DC  D 4 15  ? 150.291 178.889 155.639 1.00 85.81  ? 5   DC  D "C2'" 1 
ATOM   6670 C  "C1'" . DC  D 4 15  ? 150.233 179.017 157.163 1.00 86.03  ? 5   DC  D "C1'" 1 
ATOM   6671 N  N1    . DC  D 4 15  ? 151.242 178.176 157.854 1.00 86.55  ? 5   DC  D N1    1 
ATOM   6672 C  C2    . DC  D 4 15  ? 152.568 178.610 157.928 1.00 86.42  ? 5   DC  D C2    1 
ATOM   6673 O  O2    . DC  D 4 15  ? 152.876 179.697 157.426 1.00 83.91  ? 5   DC  D O2    1 
ATOM   6674 N  N3    . DC  D 4 15  ? 153.481 177.828 158.552 1.00 87.19  ? 5   DC  D N3    1 
ATOM   6675 C  C4    . DC  D 4 15  ? 153.108 176.664 159.083 1.00 83.00  ? 5   DC  D C4    1 
ATOM   6676 N  N4    . DC  D 4 15  ? 154.042 175.925 159.690 1.00 81.94  ? 5   DC  D N4    1 
ATOM   6677 C  C5    . DC  D 4 15  ? 151.762 176.204 159.013 1.00 81.52  ? 5   DC  D C5    1 
ATOM   6678 C  C6    . DC  D 4 15  ? 150.873 176.982 158.394 1.00 85.50  ? 5   DC  D C6    1 
ATOM   6679 P  P     . DG  D 4 16  ? 149.230 176.881 152.943 1.00 108.42 ? 6   DG  D P     1 
ATOM   6680 O  OP1   . DG  D 4 16  ? 148.436 177.120 151.719 1.00 98.77  ? 6   DG  D OP1   1 
ATOM   6681 O  OP2   . DG  D 4 16  ? 149.272 175.533 153.549 1.00 105.59 ? 6   DG  D OP2   1 
ATOM   6682 O  "O5'" . DG  D 4 16  ? 150.727 177.349 152.647 1.00 92.25  ? 6   DG  D "O5'" 1 
ATOM   6683 C  "C5'" . DG  D 4 16  ? 150.964 178.595 152.014 1.00 89.98  ? 6   DG  D "C5'" 1 
ATOM   6684 C  "C4'" . DG  D 4 16  ? 152.448 178.818 151.803 1.00 85.30  ? 6   DG  D "C4'" 1 
ATOM   6685 O  "O4'" . DG  D 4 16  ? 153.103 178.957 153.081 1.00 81.90  ? 6   DG  D "O4'" 1 
ATOM   6686 C  "C3'" . DG  D 4 16  ? 153.179 177.670 151.139 1.00 83.78  ? 6   DG  D "C3'" 1 
ATOM   6687 O  "O3'" . DG  D 4 16  ? 153.040 177.750 149.730 1.00 83.58  ? 6   DG  D "O3'" 1 
ATOM   6688 C  "C2'" . DG  D 4 16  ? 154.617 177.927 151.570 1.00 82.99  ? 6   DG  D "C2'" 1 
ATOM   6689 C  "C1'" . DG  D 4 16  ? 154.450 178.533 152.962 1.00 82.47  ? 6   DG  D "C1'" 1 
ATOM   6690 N  N9    . DG  D 4 16  ? 154.752 177.601 154.043 1.00 79.57  ? 6   DG  D N9    1 
ATOM   6691 C  C8    . DG  D 4 16  ? 153.871 176.787 154.710 1.00 79.50  ? 6   DG  D C8    1 
ATOM   6692 N  N7    . DG  D 4 16  ? 154.435 176.058 155.631 1.00 76.79  ? 6   DG  D N7    1 
ATOM   6693 C  C5    . DG  D 4 16  ? 155.776 176.414 155.571 1.00 76.09  ? 6   DG  D C5    1 
ATOM   6694 C  C6    . DG  D 4 16  ? 156.876 175.953 156.328 1.00 71.82  ? 6   DG  D C6    1 
ATOM   6695 O  O6    . DG  D 4 16  ? 156.882 175.115 157.238 1.00 69.21  ? 6   DG  D O6    1 
ATOM   6696 N  N1    . DG  D 4 16  ? 158.062 176.573 155.946 1.00 70.54  ? 6   DG  D N1    1 
ATOM   6697 C  C2    . DG  D 4 16  ? 158.169 177.513 154.953 1.00 72.87  ? 6   DG  D C2    1 
ATOM   6698 N  N2    . DG  D 4 16  ? 159.397 177.997 154.724 1.00 74.59  ? 6   DG  D N2    1 
ATOM   6699 N  N3    . DG  D 4 16  ? 157.147 177.951 154.235 1.00 74.27  ? 6   DG  D N3    1 
ATOM   6700 C  C4    . DG  D 4 16  ? 155.987 177.359 154.597 1.00 77.11  ? 6   DG  D C4    1 
ATOM   6701 P  P     . DC  D 4 17  ? 153.308 176.454 148.818 1.00 93.91  ? 7   DC  D P     1 
ATOM   6702 O  OP1   . DC  D 4 17  ? 152.906 176.789 147.435 1.00 84.07  ? 7   DC  D OP1   1 
ATOM   6703 O  OP2   . DC  D 4 17  ? 152.694 175.294 149.500 1.00 96.40  ? 7   DC  D OP2   1 
ATOM   6704 O  "O5'" . DC  D 4 17  ? 154.897 176.263 148.870 1.00 84.79  ? 7   DC  D "O5'" 1 
ATOM   6705 C  "C5'" . DC  D 4 17  ? 155.759 177.293 148.400 1.00 83.57  ? 7   DC  D "C5'" 1 
ATOM   6706 C  "C4'" . DC  D 4 17  ? 157.196 177.022 148.806 1.00 83.72  ? 7   DC  D "C4'" 1 
ATOM   6707 O  "O4'" . DC  D 4 17  ? 157.308 177.044 150.246 1.00 82.12  ? 7   DC  D "O4'" 1 
ATOM   6708 C  "C3'" . DC  D 4 17  ? 157.722 175.662 148.408 1.00 84.07  ? 7   DC  D "C3'" 1 
ATOM   6709 O  "O3'" . DC  D 4 17  ? 158.194 175.696 147.072 1.00 86.55  ? 7   DC  D "O3'" 1 
ATOM   6710 C  "C2'" . DC  D 4 17  ? 158.862 175.458 149.404 1.00 79.15  ? 7   DC  D "C2'" 1 
ATOM   6711 C  "C1'" . DC  D 4 17  ? 158.333 176.154 150.660 1.00 78.14  ? 7   DC  D "C1'" 1 
ATOM   6712 N  N1    . DC  D 4 17  ? 157.771 175.216 151.680 1.00 73.01  ? 7   DC  D N1    1 
ATOM   6713 C  C2    . DC  D 4 17  ? 158.577 174.766 152.728 1.00 70.10  ? 7   DC  D C2    1 
ATOM   6714 O  O2    . DC  D 4 17  ? 159.749 175.147 152.795 1.00 69.82  ? 7   DC  D O2    1 
ATOM   6715 N  N3    . DC  D 4 17  ? 158.049 173.921 153.644 1.00 66.59  ? 7   DC  D N3    1 
ATOM   6716 C  C4    . DC  D 4 17  ? 156.779 173.533 153.540 1.00 67.40  ? 7   DC  D C4    1 
ATOM   6717 N  N4    . DC  D 4 17  ? 156.302 172.693 154.464 1.00 64.17  ? 7   DC  D N4    1 
ATOM   6718 C  C5    . DC  D 4 17  ? 155.945 173.979 152.479 1.00 72.62  ? 7   DC  D C5    1 
ATOM   6719 C  C6    . DC  D 4 17  ? 156.476 174.813 151.583 1.00 75.80  ? 7   DC  D C6    1 
ATOM   6720 P  P     . DG  D 4 18  ? 158.351 174.330 146.246 1.00 98.51  ? 8   DG  D P     1 
ATOM   6721 O  OP1   . DG  D 4 18  ? 158.737 174.673 144.863 1.00 93.02  ? 8   DG  D OP1   1 
ATOM   6722 O  OP2   . DG  D 4 18  ? 157.146 173.510 146.495 1.00 89.03  ? 8   DG  D OP2   1 
ATOM   6723 O  "O5'" . DG  D 4 18  ? 159.576 173.599 146.959 1.00 90.96  ? 8   DG  D "O5'" 1 
ATOM   6724 C  "C5'" . DG  D 4 18  ? 159.528 172.205 147.185 1.00 81.31  ? 8   DG  D "C5'" 1 
ATOM   6725 C  "C4'" . DG  D 4 18  ? 160.719 171.755 148.001 1.00 76.90  ? 8   DG  D "C4'" 1 
ATOM   6726 O  "O4'" . DG  D 4 18  ? 160.629 172.324 149.326 1.00 78.30  ? 8   DG  D "O4'" 1 
ATOM   6727 C  "C3'" . DG  D 4 18  ? 160.811 170.259 148.210 1.00 68.58  ? 8   DG  D "C3'" 1 
ATOM   6728 O  "O3'" . DG  D 4 18  ? 161.560 169.681 147.156 1.00 67.55  ? 8   DG  D "O3'" 1 
ATOM   6729 C  "C2'" . DG  D 4 18  ? 161.549 170.149 149.542 1.00 63.13  ? 8   DG  D "C2'" 1 
ATOM   6730 C  "C1'" . DG  D 4 18  ? 161.088 171.398 150.290 1.00 61.93  ? 8   DG  D "C1'" 1 
ATOM   6731 N  N9    . DG  D 4 18  ? 160.015 171.172 151.252 1.00 58.85  ? 8   DG  D N9    1 
ATOM   6732 C  C8    . DG  D 4 18  ? 158.698 171.531 151.115 1.00 60.38  ? 8   DG  D C8    1 
ATOM   6733 N  N7    . DG  D 4 18  ? 157.965 171.214 152.142 1.00 53.66  ? 8   DG  D N7    1 
ATOM   6734 C  C5    . DG  D 4 18  ? 158.854 170.622 153.025 1.00 50.90  ? 8   DG  D C5    1 
ATOM   6735 C  C6    . DG  D 4 18  ? 158.634 170.084 154.308 1.00 47.45  ? 8   DG  D C6    1 
ATOM   6736 O  O6    . DG  D 4 18  ? 157.573 170.028 154.939 1.00 47.10  ? 8   DG  D O6    1 
ATOM   6737 N  N1    . DG  D 4 18  ? 159.802 169.575 154.864 1.00 46.22  ? 8   DG  D N1    1 
ATOM   6738 C  C2    . DG  D 4 18  ? 161.028 169.588 154.251 1.00 50.13  ? 8   DG  D C2    1 
ATOM   6739 N  N2    . DG  D 4 18  ? 162.044 169.051 154.939 1.00 47.89  ? 8   DG  D N2    1 
ATOM   6740 N  N3    . DG  D 4 18  ? 161.249 170.093 153.046 1.00 54.13  ? 8   DG  D N3    1 
ATOM   6741 C  C4    . DG  D 4 18  ? 160.121 170.592 152.495 1.00 53.31  ? 8   DG  D C4    1 
ATOM   6742 P  P     . DC  D 4 19  ? 161.103 168.286 146.515 1.00 71.31  ? 9   DC  D P     1 
ATOM   6743 O  OP1   . DC  D 4 19  ? 161.849 168.091 145.257 1.00 68.09  ? 9   DC  D OP1   1 
ATOM   6744 O  OP2   . DC  D 4 19  ? 159.627 168.274 146.513 1.00 70.86  ? 9   DC  D OP2   1 
ATOM   6745 O  "O5'" . DC  D 4 19  ? 161.635 167.202 147.554 1.00 64.47  ? 9   DC  D "O5'" 1 
ATOM   6746 C  "C5'" . DC  D 4 19  ? 163.012 167.156 147.871 1.00 61.95  ? 9   DC  D "C5'" 1 
ATOM   6747 C  "C4'" . DC  D 4 19  ? 163.239 166.474 149.205 1.00 61.33  ? 9   DC  D "C4'" 1 
ATOM   6748 O  "O4'" . DC  D 4 19  ? 162.681 167.278 150.261 1.00 55.05  ? 9   DC  D "O4'" 1 
ATOM   6749 C  "C3'" . DC  D 4 19  ? 162.558 165.133 149.366 1.00 59.87  ? 9   DC  D "C3'" 1 
ATOM   6750 O  "O3'" . DC  D 4 19  ? 163.343 164.118 148.772 1.00 66.05  ? 9   DC  D "O3'" 1 
ATOM   6751 C  "C2'" . DC  D 4 19  ? 162.520 164.993 150.883 1.00 52.74  ? 9   DC  D "C2'" 1 
ATOM   6752 C  "C1'" . DC  D 4 19  ? 162.309 166.439 151.338 1.00 47.71  ? 9   DC  D "C1'" 1 
ATOM   6753 N  N1    . DC  D 4 19  ? 160.908 166.742 151.716 1.00 46.09  ? 9   DC  D N1    1 
ATOM   6754 C  C2    . DC  D 4 19  ? 160.460 166.400 152.987 1.00 46.32  ? 9   DC  D C2    1 
ATOM   6755 O  O2    . DC  D 4 19  ? 161.247 165.853 153.766 1.00 50.77  ? 9   DC  D O2    1 
ATOM   6756 N  N3    . DC  D 4 19  ? 159.182 166.677 153.330 1.00 41.10  ? 9   DC  D N3    1 
ATOM   6757 C  C4    . DC  D 4 19  ? 158.375 167.268 152.453 1.00 40.85  ? 9   DC  D C4    1 
ATOM   6758 N  N4    . DC  D 4 19  ? 157.123 167.525 152.833 1.00 37.71  ? 9   DC  D N4    1 
ATOM   6759 C  C5    . DC  D 4 19  ? 158.815 167.624 151.148 1.00 42.99  ? 9   DC  D C5    1 
ATOM   6760 C  C6    . DC  D 4 19  ? 160.078 167.344 150.825 1.00 45.74  ? 9   DC  D C6    1 
ATOM   6761 P  P     . DA  D 4 20  ? 162.650 163.005 147.850 1.00 68.35  ? 10  DA  D P     1 
ATOM   6762 O  OP1   . DA  D 4 20  ? 163.581 162.716 146.738 1.00 64.88  ? 10  DA  D OP1   1 
ATOM   6763 O  OP2   . DA  D 4 20  ? 161.277 163.466 147.555 1.00 60.16  ? 10  DA  D OP2   1 
ATOM   6764 O  "O5'" . DA  D 4 20  ? 162.554 161.723 148.801 1.00 59.56  ? 10  DA  D "O5'" 1 
ATOM   6765 C  "C5'" . DA  D 4 20  ? 161.291 161.228 149.201 1.00 53.23  ? 10  DA  D "C5'" 1 
ATOM   6766 C  "C4'" . DA  D 4 20  ? 161.238 161.031 150.704 1.00 55.79  ? 10  DA  D "C4'" 1 
ATOM   6767 O  "O4'" . DA  D 4 20  ? 160.947 162.292 151.345 1.00 51.85  ? 10  DA  D "O4'" 1 
ATOM   6768 C  "C3'" . DA  D 4 20  ? 160.146 160.094 151.182 1.00 55.02  ? 10  DA  D "C3'" 1 
ATOM   6769 O  "O3'" . DA  D 4 20  ? 160.619 158.761 151.153 1.00 60.16  ? 10  DA  D "O3'" 1 
ATOM   6770 C  "C2'" . DA  D 4 20  ? 159.912 160.570 152.611 1.00 46.50  ? 10  DA  D "C2'" 1 
ATOM   6771 C  "C1'" . DA  D 4 20  ? 160.166 162.074 152.507 1.00 44.25  ? 10  DA  D "C1'" 1 
ATOM   6772 N  N9    . DA  D 4 20  ? 158.948 162.867 152.402 1.00 37.91  ? 10  DA  D N9    1 
ATOM   6773 C  C8    . DA  D 4 20  ? 158.600 163.703 151.386 1.00 39.78  ? 10  DA  D C8    1 
ATOM   6774 N  N7    . DA  D 4 20  ? 157.445 164.291 151.557 1.00 37.62  ? 10  DA  D N7    1 
ATOM   6775 C  C5    . DA  D 4 20  ? 157.003 163.804 152.771 1.00 35.59  ? 10  DA  D C5    1 
ATOM   6776 C  C6    . DA  D 4 20  ? 155.837 164.040 153.518 1.00 34.85  ? 10  DA  D C6    1 
ATOM   6777 N  N6    . DA  D 4 20  ? 154.866 164.863 153.123 1.00 35.74  ? 10  DA  D N6    1 
ATOM   6778 N  N1    . DA  D 4 20  ? 155.706 163.396 154.691 1.00 37.01  ? 10  DA  D N1    1 
ATOM   6779 C  C2    . DA  D 4 20  ? 156.678 162.570 155.084 1.00 36.74  ? 10  DA  D C2    1 
ATOM   6780 N  N3    . DA  D 4 20  ? 157.817 162.271 154.470 1.00 39.30  ? 10  DA  D N3    1 
ATOM   6781 C  C4    . DA  D 4 20  ? 157.918 162.927 153.306 1.00 38.75  ? 10  DA  D C4    1 
ATOM   6782 P  P     . DC  D 4 21  ? 159.755 157.612 150.445 1.00 55.67  ? 11  DC  D P     1 
ATOM   6783 O  OP1   . DC  D 4 21  ? 160.691 156.579 149.968 1.00 58.28  ? 11  DC  D OP1   1 
ATOM   6784 O  OP2   . DC  D 4 21  ? 158.842 158.263 149.487 1.00 50.54  ? 11  DC  D OP2   1 
ATOM   6785 O  "O5'" . DC  D 4 21  ? 158.876 157.011 151.631 1.00 51.58  ? 11  DC  D "O5'" 1 
ATOM   6786 C  "C5'" . DC  D 4 21  ? 159.458 156.786 152.904 1.00 44.92  ? 11  DC  D "C5'" 1 
ATOM   6787 C  "C4'" . DC  D 4 21  ? 158.418 156.926 154.001 1.00 45.11  ? 11  DC  D "C4'" 1 
ATOM   6788 O  "O4'" . DC  D 4 21  ? 158.013 158.303 154.095 1.00 44.64  ? 11  DC  D "O4'" 1 
ATOM   6789 C  "C3'" . DC  D 4 21  ? 157.128 156.165 153.760 1.00 47.26  ? 11  DC  D "C3'" 1 
ATOM   6790 O  "O3'" . DC  D 4 21  ? 157.247 154.840 154.241 1.00 46.04  ? 11  DC  D "O3'" 1 
ATOM   6791 C  "C2'" . DC  D 4 21  ? 156.109 156.957 154.574 1.00 41.93  ? 11  DC  D "C2'" 1 
ATOM   6792 C  "C1'" . DC  D 4 21  ? 156.692 158.374 154.587 1.00 40.94  ? 11  DC  D "C1'" 1 
ATOM   6793 N  N1    . DC  D 4 21  ? 155.928 159.353 153.766 1.00 34.89  ? 11  DC  D N1    1 
ATOM   6794 C  C2    . DC  D 4 21  ? 154.691 159.811 154.216 1.00 38.94  ? 11  DC  D C2    1 
ATOM   6795 O  O2    . DC  D 4 21  ? 154.249 159.383 155.286 1.00 38.88  ? 11  DC  D O2    1 
ATOM   6796 N  N3    . DC  D 4 21  ? 154.012 160.705 153.465 1.00 39.86  ? 11  DC  D N3    1 
ATOM   6797 C  C4    . DC  D 4 21  ? 154.527 161.136 152.318 1.00 36.78  ? 11  DC  D C4    1 
ATOM   6798 N  N4    . DC  D 4 21  ? 153.821 162.021 151.612 1.00 35.57  ? 11  DC  D N4    1 
ATOM   6799 C  C5    . DC  D 4 21  ? 155.789 160.683 151.844 1.00 35.29  ? 11  DC  D C5    1 
ATOM   6800 C  C6    . DC  D 4 21  ? 156.448 159.801 152.593 1.00 35.06  ? 11  DC  D C6    1 
ATOM   6801 P  P     . DC  D 4 22  ? 156.505 153.642 153.478 1.00 57.81  ? 12  DC  D P     1 
ATOM   6802 O  OP1   . DC  D 4 22  ? 157.050 152.374 154.001 1.00 55.21  ? 12  DC  D OP1   1 
ATOM   6803 O  OP2   . DC  D 4 22  ? 156.581 153.930 152.032 1.00 45.94  ? 12  DC  D OP2   1 
ATOM   6804 O  "O5'" . DC  D 4 22  ? 154.981 153.767 153.943 1.00 56.09  ? 12  DC  D "O5'" 1 
ATOM   6805 C  "C5'" . DC  D 4 22  ? 154.622 153.520 155.293 1.00 47.64  ? 12  DC  D "C5'" 1 
ATOM   6806 C  "C4'" . DC  D 4 22  ? 153.273 154.138 155.622 1.00 46.84  ? 12  DC  D "C4'" 1 
ATOM   6807 O  "O4'" . DC  D 4 22  ? 153.290 155.533 155.282 1.00 45.12  ? 12  DC  D "O4'" 1 
ATOM   6808 C  "C3'" . DC  D 4 22  ? 152.097 153.592 154.842 1.00 39.32  ? 12  DC  D "C3'" 1 
ATOM   6809 O  "O3'" . DC  D 4 22  ? 151.599 152.423 155.468 1.00 45.40  ? 12  DC  D "O3'" 1 
ATOM   6810 C  "C2'" . DC  D 4 22  ? 151.087 154.732 154.933 1.00 33.04  ? 12  DC  D "C2'" 1 
ATOM   6811 C  "C1'" . DC  D 4 22  ? 151.962 155.972 155.098 1.00 38.24  ? 12  DC  D "C1'" 1 
ATOM   6812 N  N1    . DC  D 4 22  ? 151.913 156.888 153.930 1.00 42.18  ? 12  DC  D N1    1 
ATOM   6813 C  C2    . DC  D 4 22  ? 150.808 157.715 153.764 1.00 42.55  ? 12  DC  D C2    1 
ATOM   6814 O  O2    . DC  D 4 22  ? 149.898 157.666 154.597 1.00 41.47  ? 12  DC  D O2    1 
ATOM   6815 N  N3    . DC  D 4 22  ? 150.768 158.548 152.700 1.00 39.00  ? 12  DC  D N3    1 
ATOM   6816 C  C4    . DC  D 4 22  ? 151.775 158.564 151.830 1.00 33.89  ? 12  DC  D C4    1 
ATOM   6817 N  N4    . DC  D 4 22  ? 151.694 159.402 150.797 1.00 35.63  ? 12  DC  D N4    1 
ATOM   6818 C  C5    . DC  D 4 22  ? 152.912 157.726 151.984 1.00 36.26  ? 12  DC  D C5    1 
ATOM   6819 C  C6    . DC  D 4 22  ? 152.939 156.911 153.039 1.00 39.86  ? 12  DC  D C6    1 
ATOM   6820 P  P     . DT  D 4 23  ? 150.575 151.467 154.686 1.00 45.56  ? 13  DT  D P     1 
ATOM   6821 O  OP1   . DT  D 4 23  ? 150.442 150.214 155.454 1.00 48.62  ? 13  DT  D OP1   1 
ATOM   6822 O  OP2   . DT  D 4 23  ? 151.024 151.418 153.283 1.00 48.25  ? 13  DT  D OP2   1 
ATOM   6823 O  "O5'" . DT  D 4 23  ? 149.186 152.257 154.728 1.00 46.99  ? 13  DT  D "O5'" 1 
ATOM   6824 C  "C5'" . DT  D 4 23  ? 148.568 152.547 155.971 1.00 42.74  ? 13  DT  D "C5'" 1 
ATOM   6825 C  "C4'" . DT  D 4 23  ? 147.237 153.259 155.775 1.00 45.36  ? 13  DT  D "C4'" 1 
ATOM   6826 O  "O4'" . DT  D 4 23  ? 147.437 154.509 155.072 1.00 47.04  ? 13  DT  D "O4'" 1 
ATOM   6827 C  "C3'" . DT  D 4 23  ? 146.190 152.484 154.987 1.00 48.58  ? 13  DT  D "C3'" 1 
ATOM   6828 O  "O3'" . DT  D 4 23  ? 144.953 152.567 155.659 1.00 58.77  ? 13  DT  D "O3'" 1 
ATOM   6829 C  "C2'" . DT  D 4 23  ? 146.155 153.192 153.630 1.00 44.97  ? 13  DT  D "C2'" 1 
ATOM   6830 C  "C1'" . DT  D 4 23  ? 146.533 154.616 153.998 1.00 43.24  ? 13  DT  D "C1'" 1 
ATOM   6831 N  N1    . DT  D 4 23  ? 147.227 155.345 152.908 1.00 39.08  ? 13  DT  D N1    1 
ATOM   6832 C  C2    . DT  D 4 23  ? 146.689 156.507 152.404 1.00 37.09  ? 13  DT  D C2    1 
ATOM   6833 O  O2    . DT  D 4 23  ? 145.641 156.983 152.795 1.00 34.63  ? 13  DT  D O2    1 
ATOM   6834 N  N3    . DT  D 4 23  ? 147.434 157.093 151.413 1.00 34.55  ? 13  DT  D N3    1 
ATOM   6835 C  C4    . DT  D 4 23  ? 148.629 156.642 150.894 1.00 35.03  ? 13  DT  D C4    1 
ATOM   6836 O  O4    . DT  D 4 23  ? 149.226 157.234 150.005 1.00 39.14  ? 13  DT  D O4    1 
ATOM   6837 C  C5    . DT  D 4 23  ? 149.133 155.427 151.475 1.00 35.65  ? 13  DT  D C5    1 
ATOM   6838 C  C7    . DT  D 4 23  ? 150.423 154.842 150.997 1.00 34.05  ? 13  DT  D C7    1 
ATOM   6839 C  C6    . DT  D 4 23  ? 148.419 154.849 152.440 1.00 39.05  ? 13  DT  D C6    1 
ATOM   6840 P  P     . DC  D 4 24  ? 143.668 151.799 155.089 1.00 76.17  ? 14  DC  D P     1 
ATOM   6841 O  OP1   . DC  D 4 24  ? 142.816 151.429 156.238 1.00 67.36  ? 14  DC  D OP1   1 
ATOM   6842 O  OP2   . DC  D 4 24  ? 144.157 150.755 154.164 1.00 57.05  ? 14  DC  D OP2   1 
ATOM   6843 O  "O5'" . DC  D 4 24  ? 142.910 152.930 154.260 1.00 63.27  ? 14  DC  D "O5'" 1 
ATOM   6844 C  "C5'" . DC  D 4 24  ? 141.917 152.589 153.320 1.00 57.51  ? 14  DC  D "C5'" 1 
ATOM   6845 C  "C4'" . DC  D 4 24  ? 141.615 153.785 152.449 1.00 58.30  ? 14  DC  D "C4'" 1 
ATOM   6846 O  "O4'" . DC  D 4 24  ? 142.851 154.372 152.030 1.00 53.78  ? 14  DC  D "O4'" 1 
ATOM   6847 C  "C3'" . DC  D 4 24  ? 140.878 153.472 151.162 1.00 57.28  ? 14  DC  D "C3'" 1 
ATOM   6848 O  "O3'" . DC  D 4 24  ? 139.483 153.652 151.352 1.00 61.35  ? 14  DC  D "O3'" 1 
ATOM   6849 C  "C2'" . DC  D 4 24  ? 141.441 154.487 150.155 1.00 46.70  ? 14  DC  D "C2'" 1 
ATOM   6850 C  "C1'" . DC  D 4 24  ? 142.616 155.133 150.883 1.00 41.24  ? 14  DC  D "C1'" 1 
ATOM   6851 N  N1    . DC  D 4 24  ? 143.862 155.166 150.089 1.00 36.47  ? 14  DC  D N1    1 
ATOM   6852 C  C2    . DC  D 4 24  ? 144.093 156.227 149.221 1.00 33.39  ? 14  DC  D C2    1 
ATOM   6853 O  O2    . DC  D 4 24  ? 143.247 157.115 149.121 1.00 33.01  ? 14  DC  D O2    1 
ATOM   6854 N  N3    . DC  D 4 24  ? 145.235 156.249 148.504 1.00 32.72  ? 14  DC  D N3    1 
ATOM   6855 C  C4    . DC  D 4 24  ? 146.123 155.270 148.639 1.00 31.45  ? 14  DC  D C4    1 
ATOM   6856 N  N4    . DC  D 4 24  ? 147.237 155.337 147.911 1.00 29.88  ? 14  DC  D N4    1 
ATOM   6857 C  C5    . DC  D 4 24  ? 145.907 154.179 149.520 1.00 31.90  ? 14  DC  D C5    1 
ATOM   6858 C  C6    . DC  D 4 24  ? 144.774 154.169 150.222 1.00 34.25  ? 14  DC  D C6    1 
ATOM   6859 P  P     . DA  D 4 25  ? 138.435 152.858 150.433 1.00 64.05  ? 15  DA  D P     1 
ATOM   6860 O  OP1   . DA  D 4 25  ? 137.136 152.861 151.134 1.00 65.56  ? 15  DA  D OP1   1 
ATOM   6861 O  OP2   . DA  D 4 25  ? 139.055 151.575 150.053 1.00 59.36  ? 15  DA  D OP2   1 
ATOM   6862 O  "O5'" . DA  D 4 25  ? 138.330 153.751 149.113 1.00 57.71  ? 15  DA  D "O5'" 1 
ATOM   6863 C  "C5'" . DA  D 4 25  ? 138.097 155.149 149.215 1.00 48.60  ? 15  DA  D "C5'" 1 
ATOM   6864 C  "C4'" . DA  D 4 25  ? 138.292 155.825 147.871 1.00 41.38  ? 15  DA  D "C4'" 1 
ATOM   6865 O  "O4'" . DA  D 4 25  ? 139.702 156.006 147.615 1.00 42.42  ? 15  DA  D "O4'" 1 
ATOM   6866 C  "C3'" . DA  D 4 25  ? 137.733 155.052 146.679 1.00 45.64  ? 15  DA  D "C3'" 1 
ATOM   6867 O  "O3'" . DA  D 4 25  ? 136.866 155.885 145.930 1.00 49.77  ? 15  DA  D "O3'" 1 
ATOM   6868 C  "C2'" . DA  D 4 25  ? 138.973 154.654 145.875 1.00 39.79  ? 15  DA  D "C2'" 1 
ATOM   6869 C  "C1'" . DA  D 4 25  ? 139.968 155.727 146.267 1.00 35.47  ? 15  DA  D "C1'" 1 
ATOM   6870 N  N9    . DA  D 4 25  ? 141.358 155.299 146.162 1.00 26.40  ? 15  DA  D N9    1 
ATOM   6871 C  C8    . DA  D 4 25  ? 141.985 154.374 146.936 1.00 27.20  ? 15  DA  D C8    1 
ATOM   6872 N  N7    . DA  D 4 25  ? 143.238 154.188 146.628 1.00 25.93  ? 15  DA  D N7    1 
ATOM   6873 C  C5    . DA  D 4 25  ? 143.453 155.054 145.578 1.00 23.47  ? 15  DA  D C5    1 
ATOM   6874 C  C6    . DA  D 4 25  ? 144.585 155.329 144.808 1.00 21.57  ? 15  DA  D C6    1 
ATOM   6875 N  N6    . DA  D 4 25  ? 145.758 154.729 144.995 1.00 17.23  ? 15  DA  D N6    1 
ATOM   6876 N  N1    . DA  D 4 25  ? 144.469 156.245 143.834 1.00 21.70  ? 15  DA  D N1    1 
ATOM   6877 C  C2    . DA  D 4 25  ? 143.290 156.843 143.649 1.00 23.13  ? 15  DA  D C2    1 
ATOM   6878 N  N3    . DA  D 4 25  ? 142.153 156.668 144.315 1.00 25.30  ? 15  DA  D N3    1 
ATOM   6879 C  C4    . DA  D 4 25  ? 142.306 155.750 145.276 1.00 25.23  ? 15  DA  D C4    1 
ATOM   6880 P  P     . DT  D 4 26  ? 135.755 155.239 144.970 1.00 62.06  ? 16  DT  D P     1 
ATOM   6881 O  OP1   . DT  D 4 26  ? 134.583 156.136 145.000 1.00 60.16  ? 16  DT  D OP1   1 
ATOM   6882 O  OP2   . DT  D 4 26  ? 135.594 153.815 145.331 1.00 50.31  ? 16  DT  D OP2   1 
ATOM   6883 O  "O5'" . DT  D 4 26  ? 136.418 155.329 143.521 1.00 46.69  ? 16  DT  D "O5'" 1 
ATOM   6884 C  "C5'" . DT  D 4 26  ? 136.857 156.583 143.027 1.00 42.03  ? 16  DT  D "C5'" 1 
ATOM   6885 C  "C4'" . DT  D 4 26  ? 137.717 156.406 141.793 1.00 38.51  ? 16  DT  D "C4'" 1 
ATOM   6886 O  "O4'" . DT  D 4 26  ? 139.059 156.074 142.181 1.00 35.53  ? 16  DT  D "O4'" 1 
ATOM   6887 C  "C3'" . DT  D 4 26  ? 137.267 155.289 140.855 1.00 38.98  ? 16  DT  D "C3'" 1 
ATOM   6888 O  "O3'" . DT  D 4 26  ? 136.718 155.847 139.677 1.00 42.21  ? 16  DT  D "O3'" 1 
ATOM   6889 C  "C2'" . DT  D 4 26  ? 138.545 154.488 140.559 1.00 32.08  ? 16  DT  D "C2'" 1 
ATOM   6890 C  "C1'" . DT  D 4 26  ? 139.652 155.355 141.142 1.00 31.00  ? 16  DT  D "C1'" 1 
ATOM   6891 N  N1    . DT  D 4 26  ? 140.775 154.570 141.703 1.00 26.47  ? 16  DT  D N1    1 
ATOM   6892 C  C2    . DT  D 4 26  ? 142.016 154.663 141.129 1.00 22.08  ? 16  DT  D C2    1 
ATOM   6893 O  O2    . DT  D 4 26  ? 142.253 155.368 140.170 1.00 21.78  ? 16  DT  D O2    1 
ATOM   6894 N  N3    . DT  D 4 26  ? 142.976 153.893 141.724 1.00 17.44  ? 16  DT  D N3    1 
ATOM   6895 C  C4    . DT  D 4 26  ? 142.819 153.058 142.810 1.00 20.61  ? 16  DT  D C4    1 
ATOM   6896 O  O4    . DT  D 4 26  ? 143.742 152.406 143.274 1.00 21.72  ? 16  DT  D O4    1 
ATOM   6897 C  C5    . DT  D 4 26  ? 141.492 153.006 143.359 1.00 24.09  ? 16  DT  D C5    1 
ATOM   6898 C  C7    . DT  D 4 26  ? 141.200 152.135 144.537 1.00 24.26  ? 16  DT  D C7    1 
ATOM   6899 C  C6    . DT  D 4 26  ? 140.546 153.754 142.786 1.00 25.39  ? 16  DT  D C6    1 
ATOM   6900 P  P     . DC  D 4 27  ? 136.040 154.899 138.576 1.00 46.01  ? 17  DC  D P     1 
ATOM   6901 O  OP1   . DC  D 4 27  ? 135.027 155.710 137.872 1.00 36.01  ? 17  DC  D OP1   1 
ATOM   6902 O  OP2   . DC  D 4 27  ? 135.649 153.632 139.231 1.00 45.30  ? 17  DC  D OP2   1 
ATOM   6903 O  "O5'" . DC  D 4 27  ? 137.235 154.587 137.568 1.00 43.25  ? 17  DC  D "O5'" 1 
ATOM   6904 C  "C5'" . DC  D 4 27  ? 137.982 155.652 137.022 1.00 33.74  ? 17  DC  D "C5'" 1 
ATOM   6905 C  "C4'" . DC  D 4 27  ? 139.184 155.137 136.258 1.00 24.80  ? 17  DC  D "C4'" 1 
ATOM   6906 O  "O4'" . DC  D 4 27  ? 140.198 154.690 137.186 1.00 22.07  ? 17  DC  D "O4'" 1 
ATOM   6907 C  "C3'" . DC  D 4 27  ? 138.901 153.958 135.328 1.00 26.08  ? 17  DC  D "C3'" 1 
ATOM   6908 O  "O3'" . DC  D 4 27  ? 139.253 154.292 133.994 1.00 27.33  ? 17  DC  D "O3'" 1 
ATOM   6909 C  "C2'" . DC  D 4 27  ? 139.779 152.834 135.874 1.00 25.24  ? 17  DC  D "C2'" 1 
ATOM   6910 C  "C1'" . DC  D 4 27  ? 140.856 153.590 136.633 1.00 22.28  ? 17  DC  D "C1'" 1 
ATOM   6911 N  N1    . DC  D 4 27  ? 141.463 152.794 137.735 1.00 20.18  ? 17  DC  D N1    1 
ATOM   6912 C  C2    . DC  D 4 27  ? 142.809 152.428 137.670 1.00 18.28  ? 17  DC  D C2    1 
ATOM   6913 O  O2    . DC  D 4 27  ? 143.481 152.784 136.703 1.00 17.64  ? 17  DC  D O2    1 
ATOM   6914 N  N3    . DC  D 4 27  ? 143.338 151.693 138.676 1.00 15.01  ? 17  DC  D N3    1 
ATOM   6915 C  C4    . DC  D 4 27  ? 142.575 151.328 139.700 1.00 16.30  ? 17  DC  D C4    1 
ATOM   6916 N  N4    . DC  D 4 27  ? 143.135 150.606 140.670 1.00 16.40  ? 17  DC  D N4    1 
ATOM   6917 C  C5    . DC  D 4 27  ? 141.203 151.685 139.779 1.00 19.20  ? 17  DC  D C5    1 
ATOM   6918 C  C6    . DC  D 4 27  ? 140.694 152.410 138.786 1.00 21.42  ? 17  DC  D C6    1 
ATOM   6919 P  P     . DT  D 4 28  ? 138.864 153.309 132.788 1.00 37.40  ? 18  DT  D P     1 
ATOM   6920 O  OP1   . DT  D 4 28  ? 138.536 154.139 131.617 1.00 33.01  ? 18  DT  D OP1   1 
ATOM   6921 O  OP2   . DT  D 4 28  ? 137.895 152.315 133.291 1.00 36.17  ? 18  DT  D OP2   1 
ATOM   6922 O  "O5'" . DT  D 4 28  ? 140.222 152.554 132.461 1.00 32.80  ? 18  DT  D "O5'" 1 
ATOM   6923 C  "C5'" . DT  D 4 28  ? 141.341 153.279 132.013 1.00 27.24  ? 18  DT  D "C5'" 1 
ATOM   6924 C  "C4'" . DT  D 4 28  ? 142.492 152.347 131.689 1.00 20.00  ? 18  DT  D "C4'" 1 
ATOM   6925 O  "O4'" . DT  D 4 28  ? 143.046 151.811 132.914 1.00 23.38  ? 18  DT  D "O4'" 1 
ATOM   6926 C  "C3'" . DT  D 4 28  ? 142.134 151.135 130.835 1.00 21.89  ? 18  DT  D "C3'" 1 
ATOM   6927 O  "O3'" . DT  D 4 28  ? 143.201 150.875 129.945 1.00 25.57  ? 18  DT  D "O3'" 1 
ATOM   6928 C  "C2'" . DT  D 4 28  ? 141.989 150.024 131.877 1.00 22.14  ? 18  DT  D "C2'" 1 
ATOM   6929 C  "C1'" . DT  D 4 28  ? 143.101 150.405 132.828 1.00 23.98  ? 18  DT  D "C1'" 1 
ATOM   6930 N  N1    . DT  D 4 28  ? 142.977 149.854 134.202 1.00 20.90  ? 18  DT  D N1    1 
ATOM   6931 C  C2    . DT  D 4 28  ? 144.086 149.314 134.796 1.00 21.00  ? 18  DT  D C2    1 
ATOM   6932 O  O2    . DT  D 4 28  ? 145.164 149.233 134.240 1.00 24.17  ? 18  DT  D O2    1 
ATOM   6933 N  N3    . DT  D 4 28  ? 143.890 148.858 136.065 1.00 17.73  ? 18  DT  D N3    1 
ATOM   6934 C  C4    . DT  D 4 28  ? 142.723 148.899 136.790 1.00 19.39  ? 18  DT  D C4    1 
ATOM   6935 O  O4    . DT  D 4 28  ? 142.647 148.460 137.929 1.00 19.24  ? 18  DT  D O4    1 
ATOM   6936 C  C5    . DT  D 4 28  ? 141.598 149.487 136.116 1.00 15.60  ? 18  DT  D C5    1 
ATOM   6937 C  C7    . DT  D 4 28  ? 140.274 149.575 136.806 1.00 14.19  ? 18  DT  D C7    1 
ATOM   6938 C  C6    . DT  D 4 28  ? 141.777 149.940 134.870 1.00 17.31  ? 18  DT  D C6    1 
ATOM   6939 P  P     . DC  D 4 29  ? 142.930 150.280 128.484 1.00 30.01  ? 19  DC  D P     1 
ATOM   6940 O  OP1   . DC  D 4 29  ? 143.867 150.953 127.569 1.00 28.46  ? 19  DC  D OP1   1 
ATOM   6941 O  OP2   . DC  D 4 29  ? 141.488 150.357 128.202 1.00 38.50  ? 19  DC  D OP2   1 
ATOM   6942 O  "O5'" . DC  D 4 29  ? 143.335 148.743 128.626 1.00 31.57  ? 19  DC  D "O5'" 1 
ATOM   6943 C  "C5'" . DC  D 4 29  ? 144.673 148.393 128.956 1.00 33.12  ? 19  DC  D "C5'" 1 
ATOM   6944 C  "C4'" . DC  D 4 29  ? 144.758 146.980 129.502 1.00 30.93  ? 19  DC  D "C4'" 1 
ATOM   6945 O  "O4'" . DC  D 4 29  ? 144.565 146.993 130.922 1.00 29.71  ? 19  DC  D "O4'" 1 
ATOM   6946 C  "C3'" . DC  D 4 29  ? 143.713 146.013 128.967 1.00 29.79  ? 19  DC  D "C3'" 1 
ATOM   6947 O  "O3'" . DC  D 4 29  ? 144.287 145.189 127.963 1.00 37.06  ? 19  DC  D "O3'" 1 
ATOM   6948 C  "C2'" . DC  D 4 29  ? 143.280 145.193 130.198 1.00 22.84  ? 19  DC  D "C2'" 1 
ATOM   6949 C  "C1'" . DC  D 4 29  ? 144.180 145.710 131.312 1.00 23.49  ? 19  DC  D "C1'" 1 
ATOM   6950 N  N1    . DC  D 4 29  ? 143.503 145.798 132.634 1.00 24.07  ? 19  DC  D N1    1 
ATOM   6951 C  C2    . DC  D 4 29  ? 144.189 145.418 133.790 1.00 19.45  ? 19  DC  D C2    1 
ATOM   6952 O  O2    . DC  D 4 29  ? 145.353 145.018 133.699 1.00 17.41  ? 19  DC  D O2    1 
ATOM   6953 N  N3    . DC  D 4 29  ? 143.555 145.494 134.980 1.00 16.83  ? 19  DC  D N3    1 
ATOM   6954 C  C4    . DC  D 4 29  ? 142.301 145.928 135.037 1.00 16.00  ? 19  DC  D C4    1 
ATOM   6955 N  N4    . DC  D 4 29  ? 141.717 145.988 136.231 1.00 16.87  ? 19  DC  D N4    1 
ATOM   6956 C  C5    . DC  D 4 29  ? 141.586 146.317 133.874 1.00 15.00  ? 19  DC  D C5    1 
ATOM   6957 C  C6    . DC  D 4 29  ? 142.217 146.236 132.705 1.00 20.78  ? 19  DC  D C6    1 
ATOM   6958 P  P     . DC  D 4 30  ? 143.366 144.187 127.114 1.00 46.39  ? 20  DC  D P     1 
ATOM   6959 O  OP1   . DC  D 4 30  ? 143.869 144.202 125.730 1.00 48.65  ? 20  DC  D OP1   1 
ATOM   6960 O  OP2   . DC  D 4 30  ? 141.949 144.505 127.377 1.00 42.53  ? 20  DC  D OP2   1 
ATOM   6961 O  "O5'" . DC  D 4 30  ? 143.660 142.761 127.760 1.00 38.69  ? 20  DC  D "O5'" 1 
ATOM   6962 C  "C5'" . DC  D 4 30  ? 144.983 142.268 127.794 1.00 30.18  ? 20  DC  D "C5'" 1 
ATOM   6963 C  "C4'" . DC  D 4 30  ? 145.184 141.324 128.962 1.00 28.48  ? 20  DC  D "C4'" 1 
ATOM   6964 O  "O4'" . DC  D 4 30  ? 144.993 142.031 130.200 1.00 29.32  ? 20  DC  D "O4'" 1 
ATOM   6965 C  "C3'" . DC  D 4 30  ? 144.195 140.191 129.052 1.00 24.21  ? 20  DC  D "C3'" 1 
ATOM   6966 O  "O3'" . DC  D 4 30  ? 144.561 139.151 128.167 1.00 27.88  ? 20  DC  D "O3'" 1 
ATOM   6967 C  "C2'" . DC  D 4 30  ? 144.358 139.770 130.507 1.00 24.40  ? 20  DC  D "C2'" 1 
ATOM   6968 C  "C1'" . DC  D 4 30  ? 144.691 141.092 131.209 1.00 26.24  ? 20  DC  D "C1'" 1 
ATOM   6969 N  N1    . DC  D 4 30  ? 143.578 141.608 132.048 1.00 22.31  ? 20  DC  D N1    1 
ATOM   6970 C  C2    . DC  D 4 30  ? 143.689 141.575 133.438 1.00 21.84  ? 20  DC  D C2    1 
ATOM   6971 O  O2    . DC  D 4 30  ? 144.714 141.129 133.951 1.00 21.99  ? 20  DC  D O2    1 
ATOM   6972 N  N3    . DC  D 4 30  ? 142.662 142.025 134.190 1.00 21.62  ? 20  DC  D N3    1 
ATOM   6973 C  C4    . DC  D 4 30  ? 141.569 142.492 133.604 1.00 21.86  ? 20  DC  D C4    1 
ATOM   6974 N  N4    . DC  D 4 30  ? 140.586 142.933 134.384 1.00 19.32  ? 20  DC  D N4    1 
ATOM   6975 C  C5    . DC  D 4 30  ? 141.433 142.532 132.191 1.00 22.32  ? 20  DC  D C5    1 
ATOM   6976 C  C6    . DC  D 4 30  ? 142.451 142.081 131.459 1.00 22.66  ? 20  DC  D C6    1 
ATOM   6977 P  P     . DT  D 4 31  ? 143.440 138.385 127.311 1.00 41.77  ? 21  DT  D P     1 
ATOM   6978 O  OP1   . DT  D 4 31  ? 142.119 138.765 127.839 1.00 36.04  ? 21  DT  D OP1   1 
ATOM   6979 O  OP2   . DT  D 4 31  ? 143.804 136.960 127.252 1.00 39.58  ? 21  DT  D OP2   1 
ATOM   6980 O  "O5'" . DT  D 4 31  ? 143.608 138.985 125.843 1.00 41.50  ? 21  DT  D "O5'" 1 
ATOM   6981 C  "C5'" . DT  D 4 31  ? 142.735 140.007 125.385 1.00 38.58  ? 21  DT  D "C5'" 1 
ATOM   6982 C  "C4'" . DT  D 4 31  ? 141.792 139.477 124.323 1.00 34.43  ? 21  DT  D "C4'" 1 
ATOM   6983 O  "O4'" . DT  D 4 31  ? 141.731 140.411 123.228 1.00 37.71  ? 21  DT  D "O4'" 1 
ATOM   6984 C  "C3'" . DT  D 4 31  ? 142.219 138.178 123.679 1.00 37.07  ? 21  DT  D "C3'" 1 
ATOM   6985 O  "O3'" . DT  D 4 31  ? 141.099 137.563 123.088 1.00 38.59  ? 21  DT  D "O3'" 1 
ATOM   6986 C  "C2'" . DT  D 4 31  ? 143.204 138.665 122.627 1.00 33.68  ? 21  DT  D "C2'" 1 
ATOM   6987 C  "C1'" . DT  D 4 31  ? 142.533 139.949 122.155 1.00 31.48  ? 21  DT  D "C1'" 1 
ATOM   6988 N  N1    . DT  D 4 31  ? 143.480 141.029 121.813 1.00 30.55  ? 21  DT  D N1    1 
ATOM   6989 C  C2    . DT  D 4 31  ? 143.252 141.784 120.701 1.00 28.08  ? 21  DT  D C2    1 
ATOM   6990 O  O2    . DT  D 4 31  ? 142.313 141.602 119.954 1.00 32.00  ? 21  DT  D O2    1 
ATOM   6991 N  N3    . DT  D 4 31  ? 144.165 142.766 120.481 1.00 26.98  ? 21  DT  D N3    1 
ATOM   6992 C  C4    . DT  D 4 31  ? 145.260 143.072 121.252 1.00 27.62  ? 21  DT  D C4    1 
ATOM   6993 O  O4    . DT  D 4 31  ? 146.024 143.983 120.965 1.00 22.83  ? 21  DT  D O4    1 
ATOM   6994 C  C5    . DT  D 4 31  ? 145.442 142.243 122.416 1.00 27.92  ? 21  DT  D C5    1 
ATOM   6995 C  C7    . DT  D 4 31  ? 146.598 142.472 123.337 1.00 24.09  ? 21  DT  D C7    1 
ATOM   6996 C  C6    . DT  D 4 31  ? 144.551 141.275 122.638 1.00 32.69  ? 21  DT  D C6    1 
ATOM   6997 P  P     . DA  D 4 32  ? 141.148 136.015 122.682 1.00 58.49  ? 22  DA  D P     1 
ATOM   6998 O  OP1   . DA  D 4 32  ? 139.851 135.419 123.068 1.00 52.36  ? 22  DA  D OP1   1 
ATOM   6999 O  OP2   . DA  D 4 32  ? 142.408 135.460 123.216 1.00 41.76  ? 22  DA  D OP2   1 
ATOM   7000 O  "O5'" . DA  D 4 32  ? 141.262 136.041 121.088 1.00 54.64  ? 22  DA  D "O5'" 1 
ATOM   7001 C  "C5'" . DA  D 4 32  ? 140.286 136.723 120.324 1.00 40.79  ? 22  DA  D "C5'" 1 
ATOM   7002 C  "C4'" . DA  D 4 32  ? 140.753 136.928 118.896 1.00 44.33  ? 22  DA  D "C4'" 1 
ATOM   7003 O  "O4'" . DA  D 4 32  ? 141.685 138.034 118.831 1.00 43.45  ? 22  DA  D "O4'" 1 
ATOM   7004 C  "C3'" . DA  D 4 32  ? 141.470 135.734 118.256 1.00 48.83  ? 22  DA  D "C3'" 1 
ATOM   7005 O  "O3'" . DA  D 4 32  ? 140.912 135.483 116.980 1.00 60.36  ? 22  DA  D "O3'" 1 
ATOM   7006 C  "C2'" . DA  D 4 32  ? 142.916 136.218 118.136 1.00 36.85  ? 22  DA  D "C2'" 1 
ATOM   7007 C  "C1'" . DA  D 4 32  ? 142.697 137.698 117.924 1.00 32.86  ? 22  DA  D "C1'" 1 
ATOM   7008 N  N9    . DA  D 4 32  ? 143.867 138.518 118.192 1.00 28.80  ? 22  DA  D N9    1 
ATOM   7009 C  C8    . DA  D 4 32  ? 144.803 138.332 119.164 1.00 28.81  ? 22  DA  D C8    1 
ATOM   7010 N  N7    . DA  D 4 32  ? 145.753 139.234 119.159 1.00 26.42  ? 22  DA  D N7    1 
ATOM   7011 C  C5    . DA  D 4 32  ? 145.413 140.067 118.112 1.00 23.71  ? 22  DA  D C5    1 
ATOM   7012 C  C6    . DA  D 4 32  ? 146.015 141.219 117.583 1.00 21.50  ? 22  DA  D C6    1 
ATOM   7013 N  N6    . DA  D 4 32  ? 147.139 141.753 118.068 1.00 17.18  ? 22  DA  D N6    1 
ATOM   7014 N  N1    . DA  D 4 32  ? 145.416 141.807 116.532 1.00 20.08  ? 22  DA  D N1    1 
ATOM   7015 C  C2    . DA  D 4 32  ? 144.292 141.275 116.051 1.00 19.76  ? 22  DA  D C2    1 
ATOM   7016 N  N3    . DA  D 4 32  ? 143.635 140.201 116.462 1.00 21.75  ? 22  DA  D N3    1 
ATOM   7017 C  C4    . DA  D 4 32  ? 144.254 139.638 117.506 1.00 24.31  ? 22  DA  D C4    1 
ATOM   7018 P  P     . DA  D 4 33  ? 140.857 133.994 116.385 1.00 77.68  ? 23  DA  D P     1 
ATOM   7019 O  OP1   . DA  D 4 33  ? 139.526 133.438 116.707 1.00 64.08  ? 23  DA  D OP1   1 
ATOM   7020 O  OP2   . DA  D 4 33  ? 142.080 133.283 116.810 1.00 67.30  ? 23  DA  D OP2   1 
ATOM   7021 O  "O5'" . DA  D 4 33  ? 140.946 134.222 114.808 1.00 65.95  ? 23  DA  D "O5'" 1 
ATOM   7022 C  "C5'" . DA  D 4 33  ? 140.061 135.137 114.182 1.00 61.87  ? 23  DA  D "C5'" 1 
ATOM   7023 C  "C4'" . DA  D 4 33  ? 140.806 136.045 113.222 1.00 55.94  ? 23  DA  D "C4'" 1 
ATOM   7024 O  "O4'" . DA  D 4 33  ? 141.816 136.781 113.933 1.00 50.12  ? 23  DA  D "O4'" 1 
ATOM   7025 C  "C3'" . DA  D 4 33  ? 141.524 135.325 112.083 1.00 57.73  ? 23  DA  D "C3'" 1 
ATOM   7026 O  "O3'" . DA  D 4 33  ? 140.917 135.675 110.850 1.00 68.33  ? 23  DA  D "O3'" 1 
ATOM   7027 C  "C2'" . DA  D 4 33  ? 142.981 135.811 112.162 1.00 44.40  ? 23  DA  D "C2'" 1 
ATOM   7028 C  "C1'" . DA  D 4 33  ? 142.896 137.022 113.075 1.00 40.56  ? 23  DA  D "C1'" 1 
ATOM   7029 N  N9    . DA  D 4 33  ? 144.085 137.225 113.898 1.00 33.82  ? 23  DA  D N9    1 
ATOM   7030 C  C8    . DA  D 4 33  ? 144.529 136.425 114.908 1.00 30.27  ? 23  DA  D C8    1 
ATOM   7031 N  N7    . DA  D 4 33  ? 145.616 136.860 115.486 1.00 23.46  ? 23  DA  D N7    1 
ATOM   7032 C  C5    . DA  D 4 33  ? 145.903 138.031 114.816 1.00 23.22  ? 23  DA  D C5    1 
ATOM   7033 C  C6    . DA  D 4 33  ? 146.934 138.971 114.959 1.00 19.98  ? 23  DA  D C6    1 
ATOM   7034 N  N6    . DA  D 4 33  ? 147.906 138.866 115.865 1.00 15.08  ? 23  DA  D N6    1 
ATOM   7035 N  N1    . DA  D 4 33  ? 146.928 140.028 114.132 1.00 21.94  ? 23  DA  D N1    1 
ATOM   7036 C  C2    . DA  D 4 33  ? 145.954 140.132 113.226 1.00 23.25  ? 23  DA  D C2    1 
ATOM   7037 N  N3    . DA  D 4 33  ? 144.935 139.315 112.999 1.00 22.17  ? 23  DA  D N3    1 
ATOM   7038 C  C4    . DA  D 4 33  ? 144.968 138.274 113.837 1.00 26.80  ? 23  DA  D C4    1 
ATOM   7039 P  P     . DA  D 4 34  ? 141.252 134.853 109.515 1.00 75.48  ? 24  DA  D P     1 
ATOM   7040 O  OP1   . DA  D 4 34  ? 140.035 134.877 108.679 1.00 65.24  ? 24  DA  D OP1   1 
ATOM   7041 O  OP2   . DA  D 4 34  ? 141.852 133.562 109.909 1.00 66.08  ? 24  DA  D OP2   1 
ATOM   7042 O  "O5'" . DA  D 4 34  ? 142.391 135.723 108.812 1.00 67.83  ? 24  DA  D "O5'" 1 
ATOM   7043 C  "C5'" . DA  D 4 34  ? 142.229 137.125 108.686 1.00 56.48  ? 24  DA  D "C5'" 1 
ATOM   7044 C  "C4'" . DA  D 4 34  ? 143.560 137.796 108.412 1.00 55.15  ? 24  DA  D "C4'" 1 
ATOM   7045 O  "O4'" . DA  D 4 34  ? 144.363 137.782 109.608 1.00 53.17  ? 24  DA  D "O4'" 1 
ATOM   7046 C  "C3'" . DA  D 4 34  ? 144.411 137.131 107.325 1.00 61.87  ? 24  DA  D "C3'" 1 
ATOM   7047 O  "O3'" . DA  D 4 34  ? 144.577 138.026 106.229 1.00 70.59  ? 24  DA  D "O3'" 1 
ATOM   7048 C  "C2'" . DA  D 4 34  ? 145.750 136.822 108.019 1.00 46.92  ? 24  DA  D "C2'" 1 
ATOM   7049 C  "C1'" . DA  D 4 34  ? 145.711 137.735 109.233 1.00 41.99  ? 24  DA  D "C1'" 1 
ATOM   7050 N  N9    . DA  D 4 34  ? 146.495 137.254 110.368 1.00 35.06  ? 24  DA  D N9    1 
ATOM   7051 C  C8    . DA  D 4 34  ? 146.311 136.095 111.067 1.00 33.81  ? 24  DA  D C8    1 
ATOM   7052 N  N7    . DA  D 4 34  ? 147.167 135.928 112.046 1.00 25.69  ? 24  DA  D N7    1 
ATOM   7053 C  C5    . DA  D 4 34  ? 147.961 137.059 111.988 1.00 21.56  ? 24  DA  D C5    1 
ATOM   7054 C  C6    . DA  D 4 34  ? 149.055 137.488 112.758 1.00 21.92  ? 24  DA  D C6    1 
ATOM   7055 N  N6    . DA  D 4 34  ? 149.550 136.791 113.782 1.00 19.51  ? 24  DA  D N6    1 
ATOM   7056 N  N1    . DA  D 4 34  ? 149.622 138.663 112.437 1.00 20.74  ? 24  DA  D N1    1 
ATOM   7057 C  C2    . DA  D 4 34  ? 149.123 139.357 111.415 1.00 21.88  ? 24  DA  D C2    1 
ATOM   7058 N  N3    . DA  D 4 34  ? 148.100 139.057 110.620 1.00 23.84  ? 24  DA  D N3    1 
ATOM   7059 C  C4    . DA  D 4 34  ? 147.560 137.885 110.962 1.00 25.47  ? 24  DA  D C4    1 
ATOM   7060 P  P     . DT  D 4 35  ? 145.308 137.542 104.883 1.00 87.81  ? 25  DT  D P     1 
ATOM   7061 O  OP1   . DT  D 4 35  ? 144.662 138.246 103.756 1.00 73.75  ? 25  DT  D OP1   1 
ATOM   7062 O  OP2   . DT  D 4 35  ? 145.358 136.065 104.890 1.00 69.46  ? 25  DT  D OP2   1 
ATOM   7063 O  "O5'" . DT  D 4 35  ? 146.798 138.099 105.038 1.00 68.74  ? 25  DT  D "O5'" 1 
ATOM   7064 C  "C5'" . DT  D 4 35  ? 147.013 139.491 105.189 1.00 54.73  ? 25  DT  D "C5'" 1 
ATOM   7065 C  "C4'" . DT  D 4 35  ? 148.411 139.781 105.706 1.00 54.45  ? 25  DT  D "C4'" 1 
ATOM   7066 O  "O4'" . DT  D 4 35  ? 148.639 139.075 106.945 1.00 51.99  ? 25  DT  D "O4'" 1 
ATOM   7067 C  "C3'" . DT  D 4 35  ? 149.559 139.376 104.773 1.00 58.09  ? 25  DT  D "C3'" 1 
ATOM   7068 O  "O3'" . DT  D 4 35  ? 150.331 140.518 104.459 1.00 62.85  ? 25  DT  D "O3'" 1 
ATOM   7069 C  "C2'" . DT  D 4 35  ? 150.367 138.359 105.594 1.00 47.55  ? 25  DT  D "C2'" 1 
ATOM   7070 C  "C1'" . DT  D 4 35  ? 149.999 138.750 107.012 1.00 39.24  ? 25  DT  D "C1'" 1 
ATOM   7071 N  N1    . DT  D 4 35  ? 150.181 137.666 108.022 1.00 26.57  ? 25  DT  D N1    1 
ATOM   7072 C  C2    . DT  D 4 35  ? 151.129 137.818 109.001 1.00 23.54  ? 25  DT  D C2    1 
ATOM   7073 O  O2    . DT  D 4 35  ? 151.844 138.794 109.087 1.00 28.55  ? 25  DT  D O2    1 
ATOM   7074 N  N3    . DT  D 4 35  ? 151.211 136.783 109.884 1.00 20.82  ? 25  DT  D N3    1 
ATOM   7075 C  C4    . DT  D 4 35  ? 150.456 135.632 109.887 1.00 21.69  ? 25  DT  D C4    1 
ATOM   7076 O  O4    . DT  D 4 35  ? 150.606 134.757 110.726 1.00 21.03  ? 25  DT  D O4    1 
ATOM   7077 C  C5    . DT  D 4 35  ? 149.479 135.533 108.837 1.00 21.92  ? 25  DT  D C5    1 
ATOM   7078 C  C7    . DT  D 4 35  ? 148.600 134.328 108.742 1.00 21.88  ? 25  DT  D C7    1 
ATOM   7079 C  C6    . DT  D 4 35  ? 149.386 136.544 107.965 1.00 27.76  ? 25  DT  D C6    1 
ATOM   7080 P  P     . DA  D 4 36  ? 151.345 140.502 103.216 1.00 70.64  ? 26  DA  D P     1 
ATOM   7081 O  OP1   . DA  D 4 36  ? 151.071 141.716 102.420 1.00 63.37  ? 26  DA  D OP1   1 
ATOM   7082 O  OP2   . DA  D 4 36  ? 151.275 139.169 102.579 1.00 61.57  ? 26  DA  D OP2   1 
ATOM   7083 O  "O5'" . DA  D 4 36  ? 152.780 140.646 103.903 1.00 64.75  ? 26  DA  D "O5'" 1 
ATOM   7084 C  "C5'" . DA  D 4 36  ? 152.973 141.607 104.926 1.00 53.15  ? 26  DA  D "C5'" 1 
ATOM   7085 C  "C4'" . DA  D 4 36  ? 154.194 141.276 105.762 1.00 54.64  ? 26  DA  D "C4'" 1 
ATOM   7086 O  "O4'" . DA  D 4 36  ? 153.910 140.155 106.629 1.00 55.12  ? 26  DA  D "O4'" 1 
ATOM   7087 C  "C3'" . DA  D 4 36  ? 155.446 140.901 104.970 1.00 56.84  ? 26  DA  D "C3'" 1 
ATOM   7088 O  "O3'" . DA  D 4 36  ? 156.535 141.671 105.439 1.00 62.61  ? 26  DA  D "O3'" 1 
ATOM   7089 C  "C2'" . DA  D 4 36  ? 155.632 139.405 105.259 1.00 47.77  ? 26  DA  D "C2'" 1 
ATOM   7090 C  "C1'" . DA  D 4 36  ? 155.006 139.276 106.634 1.00 42.78  ? 26  DA  D "C1'" 1 
ATOM   7091 N  N9    . DA  D 4 36  ? 154.502 137.943 106.955 1.00 32.26  ? 26  DA  D N9    1 
ATOM   7092 C  C8    . DA  D 4 36  ? 153.526 137.252 106.300 1.00 30.54  ? 26  DA  D C8    1 
ATOM   7093 N  N7    . DA  D 4 36  ? 153.258 136.086 106.831 1.00 23.53  ? 26  DA  D N7    1 
ATOM   7094 C  C5    . DA  D 4 36  ? 154.106 136.015 107.919 1.00 19.55  ? 26  DA  D C5    1 
ATOM   7095 C  C6    . DA  D 4 36  ? 154.308 135.032 108.897 1.00 19.14  ? 26  DA  D C6    1 
ATOM   7096 N  N6    . DA  D 4 36  ? 153.638 133.883 108.928 1.00 19.78  ? 26  DA  D N6    1 
ATOM   7097 N  N1    . DA  D 4 36  ? 155.233 135.273 109.844 1.00 20.88  ? 26  DA  D N1    1 
ATOM   7098 C  C2    . DA  D 4 36  ? 155.906 136.419 109.803 1.00 23.42  ? 26  DA  D C2    1 
ATOM   7099 N  N3    . DA  D 4 36  ? 155.800 137.420 108.941 1.00 25.50  ? 26  DA  D N3    1 
ATOM   7100 C  C4    . DA  D 4 36  ? 154.875 137.151 108.013 1.00 24.21  ? 26  DA  D C4    1 
ATOM   7101 P  P     . DG  D 4 37  ? 157.946 141.646 104.679 1.00 77.96  ? 27  DG  D P     1 
ATOM   7102 O  OP1   . DG  D 4 37  ? 158.458 143.032 104.653 1.00 59.83  ? 27  DG  D OP1   1 
ATOM   7103 O  OP2   . DG  D 4 37  ? 157.783 140.902 103.412 1.00 66.28  ? 27  DG  D OP2   1 
ATOM   7104 O  "O5'" . DG  D 4 37  ? 158.867 140.782 105.654 1.00 62.39  ? 27  DG  D "O5'" 1 
ATOM   7105 C  "C5'" . DG  D 4 37  ? 158.803 141.004 107.054 1.00 55.65  ? 27  DG  D "C5'" 1 
ATOM   7106 C  "C4'" . DG  D 4 37  ? 159.613 139.968 107.808 1.00 57.03  ? 27  DG  D "C4'" 1 
ATOM   7107 O  "O4'" . DG  D 4 37  ? 158.819 138.774 108.021 1.00 53.63  ? 27  DG  D "O4'" 1 
ATOM   7108 C  "C3'" . DG  D 4 37  ? 160.890 139.504 107.114 1.00 60.89  ? 27  DG  D "C3'" 1 
ATOM   7109 O  "O3'" . DG  D 4 37  ? 161.913 139.392 108.080 1.00 72.02  ? 27  DG  D "O3'" 1 
ATOM   7110 C  "C2'" . DG  D 4 37  ? 160.493 138.136 106.553 1.00 53.60  ? 27  DG  D "C2'" 1 
ATOM   7111 C  "C1'" . DG  D 4 37  ? 159.574 137.645 107.649 1.00 46.42  ? 27  DG  D "C1'" 1 
ATOM   7112 N  N9    . DG  D 4 37  ? 158.645 136.591 107.251 1.00 35.47  ? 27  DG  D N9    1 
ATOM   7113 C  C8    . DG  D 4 37  ? 157.778 136.600 106.189 1.00 32.39  ? 27  DG  D C8    1 
ATOM   7114 N  N7    . DG  D 4 37  ? 157.048 135.522 106.108 1.00 26.66  ? 27  DG  D N7    1 
ATOM   7115 C  C5    . DG  D 4 37  ? 157.451 134.757 107.192 1.00 24.92  ? 27  DG  D C5    1 
ATOM   7116 C  C6    . DG  D 4 37  ? 157.013 133.489 107.622 1.00 23.79  ? 27  DG  D C6    1 
ATOM   7117 O  O6    . DG  D 4 37  ? 156.155 132.763 107.113 1.00 25.23  ? 27  DG  D O6    1 
ATOM   7118 N  N1    . DG  D 4 37  ? 157.678 133.078 108.769 1.00 24.15  ? 27  DG  D N1    1 
ATOM   7119 C  C2    . DG  D 4 37  ? 158.646 133.804 109.413 1.00 28.62  ? 27  DG  D C2    1 
ATOM   7120 N  N2    . DG  D 4 37  ? 159.182 133.249 110.503 1.00 31.89  ? 27  DG  D N2    1 
ATOM   7121 N  N3    . DG  D 4 37  ? 159.065 134.991 109.019 1.00 25.96  ? 27  DG  D N3    1 
ATOM   7122 C  C4    . DG  D 4 37  ? 158.426 135.404 107.907 1.00 27.74  ? 27  DG  D C4    1 
ATOM   7123 P  P     . DA  D 4 38  ? 163.452 139.286 107.646 1.00 92.76  ? 28  DA  D P     1 
ATOM   7124 O  OP1   . DA  D 4 38  ? 164.156 140.405 108.309 1.00 69.61  ? 28  DA  D OP1   1 
ATOM   7125 O  OP2   . DA  D 4 38  ? 163.520 139.129 106.178 1.00 74.46  ? 28  DA  D OP2   1 
ATOM   7126 O  "O5'" . DA  D 4 38  ? 163.925 137.914 108.311 1.00 79.97  ? 28  DA  D "O5'" 1 
ATOM   7127 C  "C5'" . DA  D 4 38  ? 163.388 137.521 109.568 1.00 71.16  ? 28  DA  D "C5'" 1 
ATOM   7128 C  "C4'" . DA  D 4 38  ? 163.986 136.207 110.032 1.00 64.12  ? 28  DA  D "C4'" 1 
ATOM   7129 O  "O4'" . DA  D 4 38  ? 163.064 135.122 109.770 1.00 58.00  ? 28  DA  D "O4'" 1 
ATOM   7130 C  "C3'" . DA  D 4 38  ? 165.286 135.813 109.358 1.00 69.45  ? 28  DA  D "C3'" 1 
ATOM   7131 O  "O3'" . DA  D 4 38  ? 166.076 135.083 110.274 1.00 73.64  ? 28  DA  D "O3'" 1 
ATOM   7132 C  "C2'" . DA  D 4 38  ? 164.812 134.942 108.193 1.00 68.27  ? 28  DA  D "C2'" 1 
ATOM   7133 C  "C1'" . DA  D 4 38  ? 163.596 134.245 108.793 1.00 57.17  ? 28  DA  D "C1'" 1 
ATOM   7134 N  N9    . DA  D 4 38  ? 162.534 133.961 107.833 1.00 46.19  ? 28  DA  D N9    1 
ATOM   7135 C  C8    . DA  D 4 38  ? 162.123 134.750 106.797 1.00 45.09  ? 28  DA  D C8    1 
ATOM   7136 N  N7    . DA  D 4 38  ? 161.125 134.247 106.115 1.00 32.12  ? 28  DA  D N7    1 
ATOM   7137 C  C5    . DA  D 4 38  ? 160.856 133.051 106.756 1.00 35.52  ? 28  DA  D C5    1 
ATOM   7138 C  C6    . DA  D 4 38  ? 159.906 132.041 106.520 1.00 35.61  ? 28  DA  D C6    1 
ATOM   7139 N  N6    . DA  D 4 38  ? 159.013 132.088 105.531 1.00 29.88  ? 28  DA  D N6    1 
ATOM   7140 N  N1    . DA  D 4 38  ? 159.907 130.980 107.345 1.00 38.04  ? 28  DA  D N1    1 
ATOM   7141 C  C2    . DA  D 4 38  ? 160.801 130.937 108.334 1.00 39.44  ? 28  DA  D C2    1 
ATOM   7142 N  N3    . DA  D 4 38  ? 161.737 131.823 108.655 1.00 37.66  ? 28  DA  D N3    1 
ATOM   7143 C  C4    . DA  D 4 38  ? 161.711 132.865 107.819 1.00 39.40  ? 28  DA  D C4    1 
ATOM   7144 P  P     . DC  D 4 39  ? 167.627 134.811 109.980 1.00 82.92  ? 29  DC  D P     1 
ATOM   7145 O  OP1   . DC  D 4 39  ? 168.360 135.031 111.245 1.00 71.04  ? 29  DC  D OP1   1 
ATOM   7146 O  OP2   . DC  D 4 39  ? 168.002 135.570 108.767 1.00 76.84  ? 29  DC  D OP2   1 
ATOM   7147 O  "O5'" . DC  D 4 39  ? 167.664 133.252 109.644 1.00 83.17  ? 29  DC  D "O5'" 1 
ATOM   7148 C  "C5'" . DC  D 4 39  ? 167.054 132.334 110.537 1.00 80.44  ? 29  DC  D "C5'" 1 
ATOM   7149 C  "C4'" . DC  D 4 39  ? 166.885 130.976 109.886 1.00 85.89  ? 29  DC  D "C4'" 1 
ATOM   7150 O  "O4'" . DC  D 4 39  ? 165.678 130.964 109.072 1.00 78.31  ? 29  DC  D "O4'" 1 
ATOM   7151 C  "C3'" . DC  D 4 39  ? 168.029 130.564 108.954 1.00 89.80  ? 29  DC  D "C3'" 1 
ATOM   7152 O  "O3'" . DC  D 4 39  ? 168.375 129.205 109.182 1.00 97.66  ? 29  DC  D "O3'" 1 
ATOM   7153 C  "C2'" . DC  D 4 39  ? 167.421 130.755 107.568 1.00 82.01  ? 29  DC  D "C2'" 1 
ATOM   7154 C  "C1'" . DC  D 4 39  ? 165.983 130.363 107.841 1.00 72.97  ? 29  DC  D "C1'" 1 
ATOM   7155 N  N1    . DC  D 4 39  ? 165.021 130.829 106.805 1.00 59.39  ? 29  DC  D N1    1 
ATOM   7156 C  C2    . DC  D 4 39  ? 163.876 130.087 106.567 1.00 55.82  ? 29  DC  D C2    1 
ATOM   7157 O  O2    . DC  D 4 39  ? 163.677 129.077 107.243 1.00 59.38  ? 29  DC  D O2    1 
ATOM   7158 N  N3    . DC  D 4 39  ? 163.009 130.498 105.615 1.00 49.62  ? 29  DC  D N3    1 
ATOM   7159 C  C4    . DC  D 4 39  ? 163.266 131.602 104.915 1.00 45.72  ? 29  DC  D C4    1 
ATOM   7160 N  N4    . DC  D 4 39  ? 162.383 131.971 103.984 1.00 38.69  ? 29  DC  D N4    1 
ATOM   7161 C  C5    . DC  D 4 39  ? 164.439 132.372 105.137 1.00 48.27  ? 29  DC  D C5    1 
ATOM   7162 C  C6    . DC  D 4 39  ? 165.284 131.950 106.081 1.00 56.07  ? 29  DC  D C6    1 
ATOM   7163 P  P     . DA  D 4 40  ? 169.896 128.716 109.018 1.00 109.68 ? 30  DA  D P     1 
ATOM   7164 O  OP1   . DA  D 4 40  ? 170.606 129.012 110.282 1.00 101.97 ? 30  DA  D OP1   1 
ATOM   7165 O  OP2   . DA  D 4 40  ? 170.408 129.258 107.739 1.00 91.94  ? 30  DA  D OP2   1 
ATOM   7166 O  "O5'" . DA  D 4 40  ? 169.770 127.130 108.865 1.00 104.48 ? 30  DA  D "O5'" 1 
ATOM   7167 C  "C5'" . DA  D 4 40  ? 168.986 126.388 109.789 1.00 98.92  ? 30  DA  D "C5'" 1 
ATOM   7168 C  "C4'" . DA  D 4 40  ? 167.953 125.547 109.063 1.00 101.63 ? 30  DA  D "C4'" 1 
ATOM   7169 O  "O4'" . DA  D 4 40  ? 167.150 126.400 108.207 1.00 96.19  ? 30  DA  D "O4'" 1 
ATOM   7170 C  "C3'" . DA  D 4 40  ? 168.528 124.454 108.156 1.00 98.76  ? 30  DA  D "C3'" 1 
ATOM   7171 O  "O3'" . DA  D 4 40  ? 167.799 123.244 108.329 1.00 96.06  ? 30  DA  D "O3'" 1 
ATOM   7172 C  "C2'" . DA  D 4 40  ? 168.341 125.026 106.751 1.00 95.65  ? 30  DA  D "C2'" 1 
ATOM   7173 C  "C1'" . DA  D 4 40  ? 167.064 125.826 106.924 1.00 90.07  ? 30  DA  D "C1'" 1 
ATOM   7174 N  N9    . DA  D 4 40  ? 166.896 126.896 105.944 1.00 84.33  ? 30  DA  D N9    1 
ATOM   7175 C  C8    . DA  D 4 40  ? 167.744 127.942 105.707 1.00 81.40  ? 30  DA  D C8    1 
ATOM   7176 N  N7    . DA  D 4 40  ? 167.327 128.757 104.764 1.00 73.32  ? 30  DA  D N7    1 
ATOM   7177 C  C5    . DA  D 4 40  ? 166.124 128.206 104.357 1.00 72.83  ? 30  DA  D C5    1 
ATOM   7178 C  C6    . DA  D 4 40  ? 165.181 128.592 103.381 1.00 65.61  ? 30  DA  D C6    1 
ATOM   7179 N  N6    . DA  D 4 40  ? 165.318 129.676 102.611 1.00 55.35  ? 30  DA  D N6    1 
ATOM   7180 N  N1    . DA  D 4 40  ? 164.087 127.814 103.230 1.00 61.80  ? 30  DA  D N1    1 
ATOM   7181 C  C2    . DA  D 4 40  ? 163.956 126.732 104.006 1.00 65.68  ? 30  DA  D C2    1 
ATOM   7182 N  N3    . DA  D 4 40  ? 164.771 126.271 104.949 1.00 66.19  ? 30  DA  D N3    1 
ATOM   7183 C  C4    . DA  D 4 40  ? 165.845 127.059 105.076 1.00 74.62  ? 30  DA  D C4    1 
HETATM 7184 MG MG    . MG  E 5 .   ? 157.367 138.116 159.485 1.00 26.17  ? 801 MG  A MG    1 
HETATM 7185 MG MG    . MG  F 5 .   ? 153.892 129.198 156.317 1.00 26.47  ? 101 MG  B MG    1 
HETATM 7186 MG MG    . MG  G 5 .   ? 166.691 132.695 173.223 1.00 48.75  ? 102 MG  B MG    1 
# 
