data_9IYX
# 
_entry.id   9IYX 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9IYX         pdb_00009iyx 10.2210/pdb9iyx/pdb 
WWPDB D_1300049989 ?            ?                   
EMDB  EMD-61003    ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-15 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9IYX 
_pdbx_database_status.recvd_initial_deposition_date   2024-07-31 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Structure of HBV surface antigen determined in recombinant spherical subviral particle' 
_pdbx_database_related.db_id          EMD-61003 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              chenlei2016@pku.edu.cn 
_pdbx_contact_author.name_first         Lei 
_pdbx_contact_author.name_last          Chen 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-7619-8311 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Chen, L.' 1 0000-0002-7619-8311 
'He, X.'   2 0000-0003-0728-1354 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Cell Discov' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2056-5968 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Structural asymmetry of HBsAg dictates the binding of HBV neutralization antibodies' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
_citation_author.citation_id        primary 
_citation_author.name               'He, X.' 
_citation_author.ordinal            1 
_citation_author.identifier_ORCID   0000-0003-0728-1354 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Large envelope protein' 25430.086 2 ? ? ? ? 
2 non-polymer syn 'ZINC ION'               65.409    2 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'L glycoprotein,L-HBsAg,LHB,Large S protein,Large surface protein,Major surface antigen' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MENITSGFLGPLLVLQAGFFLLTRILTIPQSLDSWWTSLNFLGGTTVCLGQNSQSPTSNHSPTSCPPTCPGYRWMCLRRF
IIFLFILLLCLIFLLVLLDYQGMLPVCPLIPGSSTTSTGPCRTCMTTAQGTSMYPSCCCTKPSDGNCTCIPIPSSWAFGK
FLWEWASARFSWLSLLVPFVQWFVGLSPTVWLSVIWMMWYWGPSLYSILSPFLPLLPIFFCLWVYI
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MENITSGFLGPLLVLQAGFFLLTRILTIPQSLDSWWTSLNFLGGTTVCLGQNSQSPTSNHSPTSCPPTCPGYRWMCLRRF
IIFLFILLLCLIFLLVLLDYQGMLPVCPLIPGSSTTSTGPCRTCMTTAQGTSMYPSCCCTKPSDGNCTCIPIPSSWAFGK
FLWEWASARFSWLSLLVPFVQWFVGLSPTVWLSVIWMMWYWGPSLYSILSPFLPLLPIFFCLWVYI
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        'ZINC ION' 
_pdbx_entity_nonpoly.comp_id     ZN 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLU n 
1 3   ASN n 
1 4   ILE n 
1 5   THR n 
1 6   SER n 
1 7   GLY n 
1 8   PHE n 
1 9   LEU n 
1 10  GLY n 
1 11  PRO n 
1 12  LEU n 
1 13  LEU n 
1 14  VAL n 
1 15  LEU n 
1 16  GLN n 
1 17  ALA n 
1 18  GLY n 
1 19  PHE n 
1 20  PHE n 
1 21  LEU n 
1 22  LEU n 
1 23  THR n 
1 24  ARG n 
1 25  ILE n 
1 26  LEU n 
1 27  THR n 
1 28  ILE n 
1 29  PRO n 
1 30  GLN n 
1 31  SER n 
1 32  LEU n 
1 33  ASP n 
1 34  SER n 
1 35  TRP n 
1 36  TRP n 
1 37  THR n 
1 38  SER n 
1 39  LEU n 
1 40  ASN n 
1 41  PHE n 
1 42  LEU n 
1 43  GLY n 
1 44  GLY n 
1 45  THR n 
1 46  THR n 
1 47  VAL n 
1 48  CYS n 
1 49  LEU n 
1 50  GLY n 
1 51  GLN n 
1 52  ASN n 
1 53  SER n 
1 54  GLN n 
1 55  SER n 
1 56  PRO n 
1 57  THR n 
1 58  SER n 
1 59  ASN n 
1 60  HIS n 
1 61  SER n 
1 62  PRO n 
1 63  THR n 
1 64  SER n 
1 65  CYS n 
1 66  PRO n 
1 67  PRO n 
1 68  THR n 
1 69  CYS n 
1 70  PRO n 
1 71  GLY n 
1 72  TYR n 
1 73  ARG n 
1 74  TRP n 
1 75  MET n 
1 76  CYS n 
1 77  LEU n 
1 78  ARG n 
1 79  ARG n 
1 80  PHE n 
1 81  ILE n 
1 82  ILE n 
1 83  PHE n 
1 84  LEU n 
1 85  PHE n 
1 86  ILE n 
1 87  LEU n 
1 88  LEU n 
1 89  LEU n 
1 90  CYS n 
1 91  LEU n 
1 92  ILE n 
1 93  PHE n 
1 94  LEU n 
1 95  LEU n 
1 96  VAL n 
1 97  LEU n 
1 98  LEU n 
1 99  ASP n 
1 100 TYR n 
1 101 GLN n 
1 102 GLY n 
1 103 MET n 
1 104 LEU n 
1 105 PRO n 
1 106 VAL n 
1 107 CYS n 
1 108 PRO n 
1 109 LEU n 
1 110 ILE n 
1 111 PRO n 
1 112 GLY n 
1 113 SER n 
1 114 SER n 
1 115 THR n 
1 116 THR n 
1 117 SER n 
1 118 THR n 
1 119 GLY n 
1 120 PRO n 
1 121 CYS n 
1 122 ARG n 
1 123 THR n 
1 124 CYS n 
1 125 MET n 
1 126 THR n 
1 127 THR n 
1 128 ALA n 
1 129 GLN n 
1 130 GLY n 
1 131 THR n 
1 132 SER n 
1 133 MET n 
1 134 TYR n 
1 135 PRO n 
1 136 SER n 
1 137 CYS n 
1 138 CYS n 
1 139 CYS n 
1 140 THR n 
1 141 LYS n 
1 142 PRO n 
1 143 SER n 
1 144 ASP n 
1 145 GLY n 
1 146 ASN n 
1 147 CYS n 
1 148 THR n 
1 149 CYS n 
1 150 ILE n 
1 151 PRO n 
1 152 ILE n 
1 153 PRO n 
1 154 SER n 
1 155 SER n 
1 156 TRP n 
1 157 ALA n 
1 158 PHE n 
1 159 GLY n 
1 160 LYS n 
1 161 PHE n 
1 162 LEU n 
1 163 TRP n 
1 164 GLU n 
1 165 TRP n 
1 166 ALA n 
1 167 SER n 
1 168 ALA n 
1 169 ARG n 
1 170 PHE n 
1 171 SER n 
1 172 TRP n 
1 173 LEU n 
1 174 SER n 
1 175 LEU n 
1 176 LEU n 
1 177 VAL n 
1 178 PRO n 
1 179 PHE n 
1 180 VAL n 
1 181 GLN n 
1 182 TRP n 
1 183 PHE n 
1 184 VAL n 
1 185 GLY n 
1 186 LEU n 
1 187 SER n 
1 188 PRO n 
1 189 THR n 
1 190 VAL n 
1 191 TRP n 
1 192 LEU n 
1 193 SER n 
1 194 VAL n 
1 195 ILE n 
1 196 TRP n 
1 197 MET n 
1 198 MET n 
1 199 TRP n 
1 200 TYR n 
1 201 TRP n 
1 202 GLY n 
1 203 PRO n 
1 204 SER n 
1 205 LEU n 
1 206 TYR n 
1 207 SER n 
1 208 ILE n 
1 209 LEU n 
1 210 SER n 
1 211 PRO n 
1 212 PHE n 
1 213 LEU n 
1 214 PRO n 
1 215 LEU n 
1 216 LEU n 
1 217 PRO n 
1 218 ILE n 
1 219 PHE n 
1 220 PHE n 
1 221 CYS n 
1 222 LEU n 
1 223 TRP n 
1 224 VAL n 
1 225 TYR n 
1 226 ILE n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   226 
_entity_src_gen.gene_src_common_name               HBV 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'HBV genotype D3' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     1219353 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     9606 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
ZN  non-polymer         . 'ZINC ION'      ? 'Zn 2'           65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   GLU 2   2   ?   ?   ?   A . n 
A 1 3   ASN 3   3   3   ASN ASN A . n 
A 1 4   ILE 4   4   4   ILE ILE A . n 
A 1 5   THR 5   5   5   THR THR A . n 
A 1 6   SER 6   6   6   SER SER A . n 
A 1 7   GLY 7   7   7   GLY GLY A . n 
A 1 8   PHE 8   8   8   PHE PHE A . n 
A 1 9   LEU 9   9   9   LEU LEU A . n 
A 1 10  GLY 10  10  10  GLY GLY A . n 
A 1 11  PRO 11  11  11  PRO PRO A . n 
A 1 12  LEU 12  12  12  LEU LEU A . n 
A 1 13  LEU 13  13  13  LEU LEU A . n 
A 1 14  VAL 14  14  14  VAL VAL A . n 
A 1 15  LEU 15  15  15  LEU LEU A . n 
A 1 16  GLN 16  16  16  GLN GLN A . n 
A 1 17  ALA 17  17  17  ALA ALA A . n 
A 1 18  GLY 18  18  18  GLY GLY A . n 
A 1 19  PHE 19  19  19  PHE PHE A . n 
A 1 20  PHE 20  20  20  PHE PHE A . n 
A 1 21  LEU 21  21  21  LEU LEU A . n 
A 1 22  LEU 22  22  22  LEU LEU A . n 
A 1 23  THR 23  23  23  THR THR A . n 
A 1 24  ARG 24  24  24  ARG ARG A . n 
A 1 25  ILE 25  25  25  ILE ILE A . n 
A 1 26  LEU 26  26  26  LEU LEU A . n 
A 1 27  THR 27  27  27  THR THR A . n 
A 1 28  ILE 28  28  28  ILE ILE A . n 
A 1 29  PRO 29  29  29  PRO PRO A . n 
A 1 30  GLN 30  30  30  GLN GLN A . n 
A 1 31  SER 31  31  31  SER SER A . n 
A 1 32  LEU 32  32  32  LEU LEU A . n 
A 1 33  ASP 33  33  33  ASP ASP A . n 
A 1 34  SER 34  34  34  SER SER A . n 
A 1 35  TRP 35  35  35  TRP TRP A . n 
A 1 36  TRP 36  36  36  TRP TRP A . n 
A 1 37  THR 37  37  37  THR THR A . n 
A 1 38  SER 38  38  38  SER SER A . n 
A 1 39  LEU 39  39  39  LEU LEU A . n 
A 1 40  ASN 40  40  40  ASN ASN A . n 
A 1 41  PHE 41  41  41  PHE PHE A . n 
A 1 42  LEU 42  42  42  LEU LEU A . n 
A 1 43  GLY 43  43  43  GLY GLY A . n 
A 1 44  GLY 44  44  44  GLY GLY A . n 
A 1 45  THR 45  45  45  THR THR A . n 
A 1 46  THR 46  46  46  THR THR A . n 
A 1 47  VAL 47  47  47  VAL VAL A . n 
A 1 48  CYS 48  48  48  CYS CYS A . n 
A 1 49  LEU 49  49  49  LEU LEU A . n 
A 1 50  GLY 50  50  50  GLY GLY A . n 
A 1 51  GLN 51  51  ?   ?   ?   A . n 
A 1 52  ASN 52  52  ?   ?   ?   A . n 
A 1 53  SER 53  53  ?   ?   ?   A . n 
A 1 54  GLN 54  54  ?   ?   ?   A . n 
A 1 55  SER 55  55  ?   ?   ?   A . n 
A 1 56  PRO 56  56  ?   ?   ?   A . n 
A 1 57  THR 57  57  57  THR THR A . n 
A 1 58  SER 58  58  58  SER SER A . n 
A 1 59  ASN 59  59  59  ASN ASN A . n 
A 1 60  HIS 60  60  60  HIS HIS A . n 
A 1 61  SER 61  61  61  SER SER A . n 
A 1 62  PRO 62  62  62  PRO PRO A . n 
A 1 63  THR 63  63  63  THR THR A . n 
A 1 64  SER 64  64  64  SER SER A . n 
A 1 65  CYS 65  65  65  CYS CYS A . n 
A 1 66  PRO 66  66  66  PRO PRO A . n 
A 1 67  PRO 67  67  67  PRO PRO A . n 
A 1 68  THR 68  68  68  THR THR A . n 
A 1 69  CYS 69  69  69  CYS CYS A . n 
A 1 70  PRO 70  70  70  PRO PRO A . n 
A 1 71  GLY 71  71  71  GLY GLY A . n 
A 1 72  TYR 72  72  72  TYR TYR A . n 
A 1 73  ARG 73  73  73  ARG ARG A . n 
A 1 74  TRP 74  74  74  TRP TRP A . n 
A 1 75  MET 75  75  75  MET MET A . n 
A 1 76  CYS 76  76  76  CYS CYS A . n 
A 1 77  LEU 77  77  77  LEU LEU A . n 
A 1 78  ARG 78  78  78  ARG ARG A . n 
A 1 79  ARG 79  79  79  ARG ARG A . n 
A 1 80  PHE 80  80  80  PHE PHE A . n 
A 1 81  ILE 81  81  81  ILE ILE A . n 
A 1 82  ILE 82  82  82  ILE ILE A . n 
A 1 83  PHE 83  83  83  PHE PHE A . n 
A 1 84  LEU 84  84  84  LEU LEU A . n 
A 1 85  PHE 85  85  85  PHE PHE A . n 
A 1 86  ILE 86  86  86  ILE ILE A . n 
A 1 87  LEU 87  87  87  LEU LEU A . n 
A 1 88  LEU 88  88  88  LEU LEU A . n 
A 1 89  LEU 89  89  89  LEU LEU A . n 
A 1 90  CYS 90  90  90  CYS CYS A . n 
A 1 91  LEU 91  91  91  LEU LEU A . n 
A 1 92  ILE 92  92  92  ILE ILE A . n 
A 1 93  PHE 93  93  93  PHE PHE A . n 
A 1 94  LEU 94  94  94  LEU LEU A . n 
A 1 95  LEU 95  95  95  LEU LEU A . n 
A 1 96  VAL 96  96  96  VAL VAL A . n 
A 1 97  LEU 97  97  97  LEU LEU A . n 
A 1 98  LEU 98  98  98  LEU LEU A . n 
A 1 99  ASP 99  99  99  ASP ASP A . n 
A 1 100 TYR 100 100 100 TYR TYR A . n 
A 1 101 GLN 101 101 101 GLN GLN A . n 
A 1 102 GLY 102 102 102 GLY GLY A . n 
A 1 103 MET 103 103 103 MET MET A . n 
A 1 104 LEU 104 104 104 LEU LEU A . n 
A 1 105 PRO 105 105 105 PRO PRO A . n 
A 1 106 VAL 106 106 106 VAL VAL A . n 
A 1 107 CYS 107 107 107 CYS CYS A . n 
A 1 108 PRO 108 108 108 PRO PRO A . n 
A 1 109 LEU 109 109 109 LEU LEU A . n 
A 1 110 ILE 110 110 110 ILE ILE A . n 
A 1 111 PRO 111 111 ?   ?   ?   A . n 
A 1 112 GLY 112 112 ?   ?   ?   A . n 
A 1 113 SER 113 113 ?   ?   ?   A . n 
A 1 114 SER 114 114 ?   ?   ?   A . n 
A 1 115 THR 115 115 ?   ?   ?   A . n 
A 1 116 THR 116 116 ?   ?   ?   A . n 
A 1 117 SER 117 117 ?   ?   ?   A . n 
A 1 118 THR 118 118 ?   ?   ?   A . n 
A 1 119 GLY 119 119 ?   ?   ?   A . n 
A 1 120 PRO 120 120 ?   ?   ?   A . n 
A 1 121 CYS 121 121 ?   ?   ?   A . n 
A 1 122 ARG 122 122 ?   ?   ?   A . n 
A 1 123 THR 123 123 ?   ?   ?   A . n 
A 1 124 CYS 124 124 ?   ?   ?   A . n 
A 1 125 MET 125 125 ?   ?   ?   A . n 
A 1 126 THR 126 126 ?   ?   ?   A . n 
A 1 127 THR 127 127 ?   ?   ?   A . n 
A 1 128 ALA 128 128 ?   ?   ?   A . n 
A 1 129 GLN 129 129 ?   ?   ?   A . n 
A 1 130 GLY 130 130 ?   ?   ?   A . n 
A 1 131 THR 131 131 ?   ?   ?   A . n 
A 1 132 SER 132 132 ?   ?   ?   A . n 
A 1 133 MET 133 133 ?   ?   ?   A . n 
A 1 134 TYR 134 134 ?   ?   ?   A . n 
A 1 135 PRO 135 135 ?   ?   ?   A . n 
A 1 136 SER 136 136 ?   ?   ?   A . n 
A 1 137 CYS 137 137 ?   ?   ?   A . n 
A 1 138 CYS 138 138 ?   ?   ?   A . n 
A 1 139 CYS 139 139 ?   ?   ?   A . n 
A 1 140 THR 140 140 ?   ?   ?   A . n 
A 1 141 LYS 141 141 ?   ?   ?   A . n 
A 1 142 PRO 142 142 ?   ?   ?   A . n 
A 1 143 SER 143 143 ?   ?   ?   A . n 
A 1 144 ASP 144 144 ?   ?   ?   A . n 
A 1 145 GLY 145 145 ?   ?   ?   A . n 
A 1 146 ASN 146 146 ?   ?   ?   A . n 
A 1 147 CYS 147 147 ?   ?   ?   A . n 
A 1 148 THR 148 148 ?   ?   ?   A . n 
A 1 149 CYS 149 149 ?   ?   ?   A . n 
A 1 150 ILE 150 150 150 ILE ILE A . n 
A 1 151 PRO 151 151 151 PRO PRO A . n 
A 1 152 ILE 152 152 152 ILE ILE A . n 
A 1 153 PRO 153 153 153 PRO PRO A . n 
A 1 154 SER 154 154 154 SER SER A . n 
A 1 155 SER 155 155 155 SER SER A . n 
A 1 156 TRP 156 156 156 TRP TRP A . n 
A 1 157 ALA 157 157 157 ALA ALA A . n 
A 1 158 PHE 158 158 158 PHE PHE A . n 
A 1 159 GLY 159 159 159 GLY GLY A . n 
A 1 160 LYS 160 160 160 LYS LYS A . n 
A 1 161 PHE 161 161 161 PHE PHE A . n 
A 1 162 LEU 162 162 162 LEU LEU A . n 
A 1 163 TRP 163 163 163 TRP TRP A . n 
A 1 164 GLU 164 164 164 GLU GLU A . n 
A 1 165 TRP 165 165 165 TRP TRP A . n 
A 1 166 ALA 166 166 166 ALA ALA A . n 
A 1 167 SER 167 167 167 SER SER A . n 
A 1 168 ALA 168 168 168 ALA ALA A . n 
A 1 169 ARG 169 169 169 ARG ARG A . n 
A 1 170 PHE 170 170 170 PHE PHE A . n 
A 1 171 SER 171 171 171 SER SER A . n 
A 1 172 TRP 172 172 172 TRP TRP A . n 
A 1 173 LEU 173 173 173 LEU LEU A . n 
A 1 174 SER 174 174 174 SER SER A . n 
A 1 175 LEU 175 175 175 LEU LEU A . n 
A 1 176 LEU 176 176 176 LEU LEU A . n 
A 1 177 VAL 177 177 177 VAL VAL A . n 
A 1 178 PRO 178 178 178 PRO PRO A . n 
A 1 179 PHE 179 179 179 PHE PHE A . n 
A 1 180 VAL 180 180 180 VAL VAL A . n 
A 1 181 GLN 181 181 181 GLN GLN A . n 
A 1 182 TRP 182 182 182 TRP TRP A . n 
A 1 183 PHE 183 183 183 PHE PHE A . n 
A 1 184 VAL 184 184 184 VAL VAL A . n 
A 1 185 GLY 185 185 185 GLY GLY A . n 
A 1 186 LEU 186 186 186 LEU LEU A . n 
A 1 187 SER 187 187 187 SER SER A . n 
A 1 188 PRO 188 188 188 PRO PRO A . n 
A 1 189 THR 189 189 189 THR THR A . n 
A 1 190 VAL 190 190 190 VAL VAL A . n 
A 1 191 TRP 191 191 191 TRP TRP A . n 
A 1 192 LEU 192 192 192 LEU LEU A . n 
A 1 193 SER 193 193 193 SER SER A . n 
A 1 194 VAL 194 194 194 VAL VAL A . n 
A 1 195 ILE 195 195 195 ILE ILE A . n 
A 1 196 TRP 196 196 196 TRP TRP A . n 
A 1 197 MET 197 197 197 MET MET A . n 
A 1 198 MET 198 198 198 MET MET A . n 
A 1 199 TRP 199 199 199 TRP TRP A . n 
A 1 200 TYR 200 200 200 TYR TYR A . n 
A 1 201 TRP 201 201 201 TRP TRP A . n 
A 1 202 GLY 202 202 202 GLY GLY A . n 
A 1 203 PRO 203 203 203 PRO PRO A . n 
A 1 204 SER 204 204 204 SER SER A . n 
A 1 205 LEU 205 205 205 LEU LEU A . n 
A 1 206 TYR 206 206 206 TYR TYR A . n 
A 1 207 SER 207 207 207 SER SER A . n 
A 1 208 ILE 208 208 208 ILE ILE A . n 
A 1 209 LEU 209 209 209 LEU LEU A . n 
A 1 210 SER 210 210 210 SER SER A . n 
A 1 211 PRO 211 211 211 PRO PRO A . n 
A 1 212 PHE 212 212 212 PHE PHE A . n 
A 1 213 LEU 213 213 213 LEU LEU A . n 
A 1 214 PRO 214 214 214 PRO PRO A . n 
A 1 215 LEU 215 215 215 LEU LEU A . n 
A 1 216 LEU 216 216 216 LEU LEU A . n 
A 1 217 PRO 217 217 217 PRO PRO A . n 
A 1 218 ILE 218 218 218 ILE ILE A . n 
A 1 219 PHE 219 219 219 PHE PHE A . n 
A 1 220 PHE 220 220 220 PHE PHE A . n 
A 1 221 CYS 221 221 221 CYS CYS A . n 
A 1 222 LEU 222 222 222 LEU LEU A . n 
A 1 223 TRP 223 223 223 TRP TRP A . n 
A 1 224 VAL 224 224 224 VAL VAL A . n 
A 1 225 TYR 225 225 225 TYR TYR A . n 
A 1 226 ILE 226 226 226 ILE ILE A . n 
B 1 1   MET 1   1   ?   ?   ?   B . n 
B 1 2   GLU 2   2   ?   ?   ?   B . n 
B 1 3   ASN 3   3   ?   ?   ?   B . n 
B 1 4   ILE 4   4   ?   ?   ?   B . n 
B 1 5   THR 5   5   ?   ?   ?   B . n 
B 1 6   SER 6   6   ?   ?   ?   B . n 
B 1 7   GLY 7   7   ?   ?   ?   B . n 
B 1 8   PHE 8   8   ?   ?   ?   B . n 
B 1 9   LEU 9   9   9   LEU LEU B . n 
B 1 10  GLY 10  10  10  GLY GLY B . n 
B 1 11  PRO 11  11  11  PRO PRO B . n 
B 1 12  LEU 12  12  12  LEU LEU B . n 
B 1 13  LEU 13  13  13  LEU LEU B . n 
B 1 14  VAL 14  14  14  VAL VAL B . n 
B 1 15  LEU 15  15  15  LEU LEU B . n 
B 1 16  GLN 16  16  16  GLN GLN B . n 
B 1 17  ALA 17  17  17  ALA ALA B . n 
B 1 18  GLY 18  18  18  GLY GLY B . n 
B 1 19  PHE 19  19  19  PHE PHE B . n 
B 1 20  PHE 20  20  20  PHE PHE B . n 
B 1 21  LEU 21  21  21  LEU LEU B . n 
B 1 22  LEU 22  22  22  LEU LEU B . n 
B 1 23  THR 23  23  23  THR THR B . n 
B 1 24  ARG 24  24  24  ARG ARG B . n 
B 1 25  ILE 25  25  25  ILE ILE B . n 
B 1 26  LEU 26  26  26  LEU LEU B . n 
B 1 27  THR 27  27  27  THR THR B . n 
B 1 28  ILE 28  28  28  ILE ILE B . n 
B 1 29  PRO 29  29  29  PRO PRO B . n 
B 1 30  GLN 30  30  30  GLN GLN B . n 
B 1 31  SER 31  31  31  SER SER B . n 
B 1 32  LEU 32  32  32  LEU LEU B . n 
B 1 33  ASP 33  33  33  ASP ASP B . n 
B 1 34  SER 34  34  34  SER SER B . n 
B 1 35  TRP 35  35  35  TRP TRP B . n 
B 1 36  TRP 36  36  36  TRP TRP B . n 
B 1 37  THR 37  37  37  THR THR B . n 
B 1 38  SER 38  38  38  SER SER B . n 
B 1 39  LEU 39  39  39  LEU LEU B . n 
B 1 40  ASN 40  40  40  ASN ASN B . n 
B 1 41  PHE 41  41  41  PHE PHE B . n 
B 1 42  LEU 42  42  42  LEU LEU B . n 
B 1 43  GLY 43  43  43  GLY GLY B . n 
B 1 44  GLY 44  44  44  GLY GLY B . n 
B 1 45  THR 45  45  45  THR THR B . n 
B 1 46  THR 46  46  46  THR THR B . n 
B 1 47  VAL 47  47  47  VAL VAL B . n 
B 1 48  CYS 48  48  48  CYS CYS B . n 
B 1 49  LEU 49  49  49  LEU LEU B . n 
B 1 50  GLY 50  50  50  GLY GLY B . n 
B 1 51  GLN 51  51  ?   ?   ?   B . n 
B 1 52  ASN 52  52  ?   ?   ?   B . n 
B 1 53  SER 53  53  ?   ?   ?   B . n 
B 1 54  GLN 54  54  ?   ?   ?   B . n 
B 1 55  SER 55  55  ?   ?   ?   B . n 
B 1 56  PRO 56  56  ?   ?   ?   B . n 
B 1 57  THR 57  57  ?   ?   ?   B . n 
B 1 58  SER 58  58  58  SER SER B . n 
B 1 59  ASN 59  59  59  ASN ASN B . n 
B 1 60  HIS 60  60  60  HIS HIS B . n 
B 1 61  SER 61  61  61  SER SER B . n 
B 1 62  PRO 62  62  62  PRO PRO B . n 
B 1 63  THR 63  63  63  THR THR B . n 
B 1 64  SER 64  64  64  SER SER B . n 
B 1 65  CYS 65  65  65  CYS CYS B . n 
B 1 66  PRO 66  66  66  PRO PRO B . n 
B 1 67  PRO 67  67  67  PRO PRO B . n 
B 1 68  THR 68  68  68  THR THR B . n 
B 1 69  CYS 69  69  69  CYS CYS B . n 
B 1 70  PRO 70  70  70  PRO PRO B . n 
B 1 71  GLY 71  71  71  GLY GLY B . n 
B 1 72  TYR 72  72  72  TYR TYR B . n 
B 1 73  ARG 73  73  73  ARG ARG B . n 
B 1 74  TRP 74  74  74  TRP TRP B . n 
B 1 75  MET 75  75  75  MET MET B . n 
B 1 76  CYS 76  76  76  CYS CYS B . n 
B 1 77  LEU 77  77  77  LEU LEU B . n 
B 1 78  ARG 78  78  78  ARG ARG B . n 
B 1 79  ARG 79  79  79  ARG ARG B . n 
B 1 80  PHE 80  80  80  PHE PHE B . n 
B 1 81  ILE 81  81  81  ILE ILE B . n 
B 1 82  ILE 82  82  82  ILE ILE B . n 
B 1 83  PHE 83  83  83  PHE PHE B . n 
B 1 84  LEU 84  84  84  LEU LEU B . n 
B 1 85  PHE 85  85  85  PHE PHE B . n 
B 1 86  ILE 86  86  86  ILE ILE B . n 
B 1 87  LEU 87  87  87  LEU LEU B . n 
B 1 88  LEU 88  88  88  LEU LEU B . n 
B 1 89  LEU 89  89  89  LEU LEU B . n 
B 1 90  CYS 90  90  90  CYS CYS B . n 
B 1 91  LEU 91  91  91  LEU LEU B . n 
B 1 92  ILE 92  92  92  ILE ILE B . n 
B 1 93  PHE 93  93  93  PHE PHE B . n 
B 1 94  LEU 94  94  94  LEU LEU B . n 
B 1 95  LEU 95  95  95  LEU LEU B . n 
B 1 96  VAL 96  96  96  VAL VAL B . n 
B 1 97  LEU 97  97  97  LEU LEU B . n 
B 1 98  LEU 98  98  98  LEU LEU B . n 
B 1 99  ASP 99  99  99  ASP ASP B . n 
B 1 100 TYR 100 100 100 TYR TYR B . n 
B 1 101 GLN 101 101 101 GLN GLN B . n 
B 1 102 GLY 102 102 102 GLY GLY B . n 
B 1 103 MET 103 103 103 MET MET B . n 
B 1 104 LEU 104 104 104 LEU LEU B . n 
B 1 105 PRO 105 105 105 PRO PRO B . n 
B 1 106 VAL 106 106 106 VAL VAL B . n 
B 1 107 CYS 107 107 107 CYS CYS B . n 
B 1 108 PRO 108 108 108 PRO PRO B . n 
B 1 109 LEU 109 109 109 LEU LEU B . n 
B 1 110 ILE 110 110 110 ILE ILE B . n 
B 1 111 PRO 111 111 ?   ?   ?   B . n 
B 1 112 GLY 112 112 ?   ?   ?   B . n 
B 1 113 SER 113 113 ?   ?   ?   B . n 
B 1 114 SER 114 114 ?   ?   ?   B . n 
B 1 115 THR 115 115 ?   ?   ?   B . n 
B 1 116 THR 116 116 ?   ?   ?   B . n 
B 1 117 SER 117 117 ?   ?   ?   B . n 
B 1 118 THR 118 118 ?   ?   ?   B . n 
B 1 119 GLY 119 119 ?   ?   ?   B . n 
B 1 120 PRO 120 120 ?   ?   ?   B . n 
B 1 121 CYS 121 121 ?   ?   ?   B . n 
B 1 122 ARG 122 122 ?   ?   ?   B . n 
B 1 123 THR 123 123 ?   ?   ?   B . n 
B 1 124 CYS 124 124 ?   ?   ?   B . n 
B 1 125 MET 125 125 ?   ?   ?   B . n 
B 1 126 THR 126 126 ?   ?   ?   B . n 
B 1 127 THR 127 127 ?   ?   ?   B . n 
B 1 128 ALA 128 128 ?   ?   ?   B . n 
B 1 129 GLN 129 129 ?   ?   ?   B . n 
B 1 130 GLY 130 130 ?   ?   ?   B . n 
B 1 131 THR 131 131 ?   ?   ?   B . n 
B 1 132 SER 132 132 ?   ?   ?   B . n 
B 1 133 MET 133 133 ?   ?   ?   B . n 
B 1 134 TYR 134 134 ?   ?   ?   B . n 
B 1 135 PRO 135 135 ?   ?   ?   B . n 
B 1 136 SER 136 136 ?   ?   ?   B . n 
B 1 137 CYS 137 137 ?   ?   ?   B . n 
B 1 138 CYS 138 138 ?   ?   ?   B . n 
B 1 139 CYS 139 139 ?   ?   ?   B . n 
B 1 140 THR 140 140 ?   ?   ?   B . n 
B 1 141 LYS 141 141 ?   ?   ?   B . n 
B 1 142 PRO 142 142 ?   ?   ?   B . n 
B 1 143 SER 143 143 ?   ?   ?   B . n 
B 1 144 ASP 144 144 ?   ?   ?   B . n 
B 1 145 GLY 145 145 ?   ?   ?   B . n 
B 1 146 ASN 146 146 ?   ?   ?   B . n 
B 1 147 CYS 147 147 ?   ?   ?   B . n 
B 1 148 THR 148 148 ?   ?   ?   B . n 
B 1 149 CYS 149 149 ?   ?   ?   B . n 
B 1 150 ILE 150 150 150 ILE ILE B . n 
B 1 151 PRO 151 151 151 PRO PRO B . n 
B 1 152 ILE 152 152 152 ILE ILE B . n 
B 1 153 PRO 153 153 153 PRO PRO B . n 
B 1 154 SER 154 154 154 SER SER B . n 
B 1 155 SER 155 155 155 SER SER B . n 
B 1 156 TRP 156 156 156 TRP TRP B . n 
B 1 157 ALA 157 157 157 ALA ALA B . n 
B 1 158 PHE 158 158 158 PHE PHE B . n 
B 1 159 GLY 159 159 159 GLY GLY B . n 
B 1 160 LYS 160 160 160 LYS LYS B . n 
B 1 161 PHE 161 161 161 PHE PHE B . n 
B 1 162 LEU 162 162 162 LEU LEU B . n 
B 1 163 TRP 163 163 163 TRP TRP B . n 
B 1 164 GLU 164 164 164 GLU GLU B . n 
B 1 165 TRP 165 165 165 TRP TRP B . n 
B 1 166 ALA 166 166 166 ALA ALA B . n 
B 1 167 SER 167 167 167 SER SER B . n 
B 1 168 ALA 168 168 168 ALA ALA B . n 
B 1 169 ARG 169 169 169 ARG ARG B . n 
B 1 170 PHE 170 170 170 PHE PHE B . n 
B 1 171 SER 171 171 171 SER SER B . n 
B 1 172 TRP 172 172 172 TRP TRP B . n 
B 1 173 LEU 173 173 173 LEU LEU B . n 
B 1 174 SER 174 174 174 SER SER B . n 
B 1 175 LEU 175 175 175 LEU LEU B . n 
B 1 176 LEU 176 176 176 LEU LEU B . n 
B 1 177 VAL 177 177 177 VAL VAL B . n 
B 1 178 PRO 178 178 178 PRO PRO B . n 
B 1 179 PHE 179 179 179 PHE PHE B . n 
B 1 180 VAL 180 180 180 VAL VAL B . n 
B 1 181 GLN 181 181 181 GLN GLN B . n 
B 1 182 TRP 182 182 182 TRP TRP B . n 
B 1 183 PHE 183 183 183 PHE PHE B . n 
B 1 184 VAL 184 184 184 VAL VAL B . n 
B 1 185 GLY 185 185 185 GLY GLY B . n 
B 1 186 LEU 186 186 186 LEU LEU B . n 
B 1 187 SER 187 187 187 SER SER B . n 
B 1 188 PRO 188 188 188 PRO PRO B . n 
B 1 189 THR 189 189 189 THR THR B . n 
B 1 190 VAL 190 190 190 VAL VAL B . n 
B 1 191 TRP 191 191 191 TRP TRP B . n 
B 1 192 LEU 192 192 192 LEU LEU B . n 
B 1 193 SER 193 193 193 SER SER B . n 
B 1 194 VAL 194 194 194 VAL VAL B . n 
B 1 195 ILE 195 195 195 ILE ILE B . n 
B 1 196 TRP 196 196 196 TRP TRP B . n 
B 1 197 MET 197 197 197 MET MET B . n 
B 1 198 MET 198 198 198 MET MET B . n 
B 1 199 TRP 199 199 199 TRP TRP B . n 
B 1 200 TYR 200 200 200 TYR TYR B . n 
B 1 201 TRP 201 201 201 TRP TRP B . n 
B 1 202 GLY 202 202 202 GLY GLY B . n 
B 1 203 PRO 203 203 203 PRO PRO B . n 
B 1 204 SER 204 204 204 SER SER B . n 
B 1 205 LEU 205 205 205 LEU LEU B . n 
B 1 206 TYR 206 206 206 TYR TYR B . n 
B 1 207 SER 207 207 207 SER SER B . n 
B 1 208 ILE 208 208 208 ILE ILE B . n 
B 1 209 LEU 209 209 209 LEU LEU B . n 
B 1 210 SER 210 210 210 SER SER B . n 
B 1 211 PRO 211 211 211 PRO PRO B . n 
B 1 212 PHE 212 212 212 PHE PHE B . n 
B 1 213 LEU 213 213 213 LEU LEU B . n 
B 1 214 PRO 214 214 214 PRO PRO B . n 
B 1 215 LEU 215 215 215 LEU LEU B . n 
B 1 216 LEU 216 216 216 LEU LEU B . n 
B 1 217 PRO 217 217 217 PRO PRO B . n 
B 1 218 ILE 218 218 218 ILE ILE B . n 
B 1 219 PHE 219 219 219 PHE PHE B . n 
B 1 220 PHE 220 220 220 PHE PHE B . n 
B 1 221 CYS 221 221 221 CYS CYS B . n 
B 1 222 LEU 222 222 222 LEU LEU B . n 
B 1 223 TRP 223 223 223 TRP TRP B . n 
B 1 224 VAL 224 224 224 VAL VAL B . n 
B 1 225 TYR 225 225 225 TYR TYR B . n 
B 1 226 ILE 226 226 226 ILE ILE B . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 ZN 1 1001 1001 ZN ZN A . 
D 2 ZN 1 301  1002 ZN ZN B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1   1 Y 1 A ASN 3   ? CG  ? A ASN 3   CG  
2   1 Y 1 A ASN 3   ? OD1 ? A ASN 3   OD1 
3   1 Y 1 A ASN 3   ? ND2 ? A ASN 3   ND2 
4   1 Y 1 A SER 6   ? OG  ? A SER 6   OG  
5   1 Y 1 A LEU 13  ? CG  ? A LEU 13  CG  
6   1 Y 1 A LEU 13  ? CD1 ? A LEU 13  CD1 
7   1 Y 1 A LEU 13  ? CD2 ? A LEU 13  CD2 
8   1 Y 1 A THR 57  ? OG1 ? A THR 57  OG1 
9   1 Y 1 A THR 57  ? CG2 ? A THR 57  CG2 
10  1 Y 1 A ASN 59  ? CG  ? A ASN 59  CG  
11  1 Y 1 A ASN 59  ? OD1 ? A ASN 59  OD1 
12  1 Y 1 A ASN 59  ? ND2 ? A ASN 59  ND2 
13  1 Y 1 A THR 68  ? OG1 ? A THR 68  OG1 
14  1 Y 1 A THR 68  ? CG2 ? A THR 68  CG2 
15  1 Y 1 A PHE 170 ? CG  ? A PHE 170 CG  
16  1 Y 1 A PHE 170 ? CD1 ? A PHE 170 CD1 
17  1 Y 1 A PHE 170 ? CD2 ? A PHE 170 CD2 
18  1 Y 1 A PHE 170 ? CE1 ? A PHE 170 CE1 
19  1 Y 1 A PHE 170 ? CE2 ? A PHE 170 CE2 
20  1 Y 1 A PHE 170 ? CZ  ? A PHE 170 CZ  
21  1 Y 1 A SER 171 ? OG  ? A SER 171 OG  
22  1 Y 1 A TRP 172 ? CG  ? A TRP 172 CG  
23  1 Y 1 A TRP 172 ? CD1 ? A TRP 172 CD1 
24  1 Y 1 A TRP 172 ? CD2 ? A TRP 172 CD2 
25  1 Y 1 A TRP 172 ? NE1 ? A TRP 172 NE1 
26  1 Y 1 A TRP 172 ? CE2 ? A TRP 172 CE2 
27  1 Y 1 A TRP 172 ? CE3 ? A TRP 172 CE3 
28  1 Y 1 A TRP 172 ? CZ2 ? A TRP 172 CZ2 
29  1 Y 1 A TRP 172 ? CZ3 ? A TRP 172 CZ3 
30  1 Y 1 A TRP 172 ? CH2 ? A TRP 172 CH2 
31  1 Y 1 A LEU 173 ? CG  ? A LEU 173 CG  
32  1 Y 1 A LEU 173 ? CD1 ? A LEU 173 CD1 
33  1 Y 1 A LEU 173 ? CD2 ? A LEU 173 CD2 
34  1 Y 1 A SER 174 ? OG  ? A SER 174 OG  
35  1 Y 1 A LEU 175 ? CG  ? A LEU 175 CG  
36  1 Y 1 A LEU 175 ? CD1 ? A LEU 175 CD1 
37  1 Y 1 A LEU 175 ? CD2 ? A LEU 175 CD2 
38  1 Y 1 A LEU 176 ? CG  ? A LEU 176 CG  
39  1 Y 1 A LEU 176 ? CD1 ? A LEU 176 CD1 
40  1 Y 1 A LEU 176 ? CD2 ? A LEU 176 CD2 
41  1 Y 1 A VAL 177 ? CG1 ? A VAL 177 CG1 
42  1 Y 1 A VAL 177 ? CG2 ? A VAL 177 CG2 
43  1 Y 1 A VAL 180 ? CG1 ? A VAL 180 CG1 
44  1 Y 1 A VAL 180 ? CG2 ? A VAL 180 CG2 
45  1 Y 1 A GLN 181 ? CG  ? A GLN 181 CG  
46  1 Y 1 A GLN 181 ? CD  ? A GLN 181 CD  
47  1 Y 1 A GLN 181 ? OE1 ? A GLN 181 OE1 
48  1 Y 1 A GLN 181 ? NE2 ? A GLN 181 NE2 
49  1 Y 1 A PHE 183 ? CG  ? A PHE 183 CG  
50  1 Y 1 A PHE 183 ? CD1 ? A PHE 183 CD1 
51  1 Y 1 A PHE 183 ? CD2 ? A PHE 183 CD2 
52  1 Y 1 A PHE 183 ? CE1 ? A PHE 183 CE1 
53  1 Y 1 A PHE 183 ? CE2 ? A PHE 183 CE2 
54  1 Y 1 A PHE 183 ? CZ  ? A PHE 183 CZ  
55  1 Y 1 A VAL 184 ? CG1 ? A VAL 184 CG1 
56  1 Y 1 A VAL 184 ? CG2 ? A VAL 184 CG2 
57  1 Y 1 A LEU 186 ? CG  ? A LEU 186 CG  
58  1 Y 1 A LEU 186 ? CD1 ? A LEU 186 CD1 
59  1 Y 1 A LEU 186 ? CD2 ? A LEU 186 CD2 
60  1 Y 1 A THR 189 ? OG1 ? A THR 189 OG1 
61  1 Y 1 A THR 189 ? CG2 ? A THR 189 CG2 
62  1 Y 1 A VAL 190 ? CG1 ? A VAL 190 CG1 
63  1 Y 1 A VAL 190 ? CG2 ? A VAL 190 CG2 
64  1 Y 1 A TRP 191 ? CG  ? A TRP 191 CG  
65  1 Y 1 A TRP 191 ? CD1 ? A TRP 191 CD1 
66  1 Y 1 A TRP 191 ? CD2 ? A TRP 191 CD2 
67  1 Y 1 A TRP 191 ? NE1 ? A TRP 191 NE1 
68  1 Y 1 A TRP 191 ? CE2 ? A TRP 191 CE2 
69  1 Y 1 A TRP 191 ? CE3 ? A TRP 191 CE3 
70  1 Y 1 A TRP 191 ? CZ2 ? A TRP 191 CZ2 
71  1 Y 1 A TRP 191 ? CZ3 ? A TRP 191 CZ3 
72  1 Y 1 A TRP 191 ? CH2 ? A TRP 191 CH2 
73  1 Y 1 A LEU 192 ? CG  ? A LEU 192 CG  
74  1 Y 1 A LEU 192 ? CD1 ? A LEU 192 CD1 
75  1 Y 1 A LEU 192 ? CD2 ? A LEU 192 CD2 
76  1 Y 1 A SER 193 ? OG  ? A SER 193 OG  
77  1 Y 1 A VAL 194 ? CG1 ? A VAL 194 CG1 
78  1 Y 1 A VAL 194 ? CG2 ? A VAL 194 CG2 
79  1 Y 1 A MET 197 ? CG  ? A MET 197 CG  
80  1 Y 1 A MET 197 ? SD  ? A MET 197 SD  
81  1 Y 1 A MET 197 ? CE  ? A MET 197 CE  
82  1 Y 1 A MET 198 ? CG  ? A MET 198 CG  
83  1 Y 1 A MET 198 ? SD  ? A MET 198 SD  
84  1 Y 1 A MET 198 ? CE  ? A MET 198 CE  
85  1 Y 1 A TRP 201 ? CG  ? A TRP 201 CG  
86  1 Y 1 A TRP 201 ? CD1 ? A TRP 201 CD1 
87  1 Y 1 A TRP 201 ? CD2 ? A TRP 201 CD2 
88  1 Y 1 A TRP 201 ? NE1 ? A TRP 201 NE1 
89  1 Y 1 A TRP 201 ? CE2 ? A TRP 201 CE2 
90  1 Y 1 A TRP 201 ? CE3 ? A TRP 201 CE3 
91  1 Y 1 A TRP 201 ? CZ2 ? A TRP 201 CZ2 
92  1 Y 1 A TRP 201 ? CZ3 ? A TRP 201 CZ3 
93  1 Y 1 A TRP 201 ? CH2 ? A TRP 201 CH2 
94  1 Y 1 A SER 204 ? OG  ? A SER 204 OG  
95  1 Y 1 A LEU 205 ? CG  ? A LEU 205 CG  
96  1 Y 1 A LEU 205 ? CD1 ? A LEU 205 CD1 
97  1 Y 1 A LEU 205 ? CD2 ? A LEU 205 CD2 
98  1 Y 1 A SER 207 ? OG  ? A SER 207 OG  
99  1 Y 1 A ILE 208 ? CG1 ? A ILE 208 CG1 
100 1 Y 1 A ILE 208 ? CG2 ? A ILE 208 CG2 
101 1 Y 1 A ILE 208 ? CD1 ? A ILE 208 CD1 
102 1 Y 1 A LEU 209 ? CG  ? A LEU 209 CG  
103 1 Y 1 A LEU 209 ? CD1 ? A LEU 209 CD1 
104 1 Y 1 A LEU 209 ? CD2 ? A LEU 209 CD2 
105 1 Y 1 A SER 210 ? OG  ? A SER 210 OG  
106 1 Y 1 A PHE 212 ? CG  ? A PHE 212 CG  
107 1 Y 1 A PHE 212 ? CD1 ? A PHE 212 CD1 
108 1 Y 1 A PHE 212 ? CD2 ? A PHE 212 CD2 
109 1 Y 1 A PHE 212 ? CE1 ? A PHE 212 CE1 
110 1 Y 1 A PHE 212 ? CE2 ? A PHE 212 CE2 
111 1 Y 1 A PHE 212 ? CZ  ? A PHE 212 CZ  
112 1 Y 1 A LEU 213 ? CG  ? A LEU 213 CG  
113 1 Y 1 A LEU 213 ? CD1 ? A LEU 213 CD1 
114 1 Y 1 A LEU 213 ? CD2 ? A LEU 213 CD2 
115 1 Y 1 A LEU 215 ? CG  ? A LEU 215 CG  
116 1 Y 1 A LEU 215 ? CD1 ? A LEU 215 CD1 
117 1 Y 1 A LEU 215 ? CD2 ? A LEU 215 CD2 
118 1 Y 1 A LEU 216 ? CG  ? A LEU 216 CG  
119 1 Y 1 A LEU 216 ? CD1 ? A LEU 216 CD1 
120 1 Y 1 A LEU 216 ? CD2 ? A LEU 216 CD2 
121 1 Y 1 A PRO 217 ? CG  ? A PRO 217 CG  
122 1 Y 1 A PRO 217 ? CD  ? A PRO 217 CD  
123 1 Y 1 A PHE 219 ? CG  ? A PHE 219 CG  
124 1 Y 1 A PHE 219 ? CD1 ? A PHE 219 CD1 
125 1 Y 1 A PHE 219 ? CD2 ? A PHE 219 CD2 
126 1 Y 1 A PHE 219 ? CE1 ? A PHE 219 CE1 
127 1 Y 1 A PHE 219 ? CE2 ? A PHE 219 CE2 
128 1 Y 1 A PHE 219 ? CZ  ? A PHE 219 CZ  
129 1 Y 1 A PHE 220 ? CG  ? A PHE 220 CG  
130 1 Y 1 A PHE 220 ? CD1 ? A PHE 220 CD1 
131 1 Y 1 A PHE 220 ? CD2 ? A PHE 220 CD2 
132 1 Y 1 A PHE 220 ? CE1 ? A PHE 220 CE1 
133 1 Y 1 A PHE 220 ? CE2 ? A PHE 220 CE2 
134 1 Y 1 A PHE 220 ? CZ  ? A PHE 220 CZ  
135 1 Y 1 A CYS 221 ? SG  ? A CYS 221 SG  
136 1 Y 1 A LEU 222 ? CG  ? A LEU 222 CG  
137 1 Y 1 A LEU 222 ? CD1 ? A LEU 222 CD1 
138 1 Y 1 A LEU 222 ? CD2 ? A LEU 222 CD2 
139 1 Y 1 A TRP 223 ? CG  ? A TRP 223 CG  
140 1 Y 1 A TRP 223 ? CD1 ? A TRP 223 CD1 
141 1 Y 1 A TRP 223 ? CD2 ? A TRP 223 CD2 
142 1 Y 1 A TRP 223 ? NE1 ? A TRP 223 NE1 
143 1 Y 1 A TRP 223 ? CE2 ? A TRP 223 CE2 
144 1 Y 1 A TRP 223 ? CE3 ? A TRP 223 CE3 
145 1 Y 1 A TRP 223 ? CZ2 ? A TRP 223 CZ2 
146 1 Y 1 A TRP 223 ? CZ3 ? A TRP 223 CZ3 
147 1 Y 1 A TRP 223 ? CH2 ? A TRP 223 CH2 
148 1 Y 1 A VAL 224 ? CG1 ? A VAL 224 CG1 
149 1 Y 1 A VAL 224 ? CG2 ? A VAL 224 CG2 
150 1 Y 1 A TYR 225 ? CG  ? A TYR 225 CG  
151 1 Y 1 A TYR 225 ? CD1 ? A TYR 225 CD1 
152 1 Y 1 A TYR 225 ? CD2 ? A TYR 225 CD2 
153 1 Y 1 A TYR 225 ? CE1 ? A TYR 225 CE1 
154 1 Y 1 A TYR 225 ? CE2 ? A TYR 225 CE2 
155 1 Y 1 A TYR 225 ? CZ  ? A TYR 225 CZ  
156 1 Y 1 A TYR 225 ? OH  ? A TYR 225 OH  
157 1 Y 1 A ILE 226 ? CG1 ? A ILE 226 CG1 
158 1 Y 1 A ILE 226 ? CG2 ? A ILE 226 CG2 
159 1 Y 1 A ILE 226 ? CD1 ? A ILE 226 CD1 
160 1 Y 1 B LEU 12  ? CG  ? B LEU 12  CG  
161 1 Y 1 B LEU 12  ? CD1 ? B LEU 12  CD1 
162 1 Y 1 B LEU 12  ? CD2 ? B LEU 12  CD2 
163 1 Y 1 B GLN 16  ? CG  ? B GLN 16  CG  
164 1 Y 1 B GLN 16  ? CD  ? B GLN 16  CD  
165 1 Y 1 B GLN 16  ? OE1 ? B GLN 16  OE1 
166 1 Y 1 B GLN 16  ? NE2 ? B GLN 16  NE2 
167 1 Y 1 B TRP 172 ? CG  ? B TRP 172 CG  
168 1 Y 1 B TRP 172 ? CD1 ? B TRP 172 CD1 
169 1 Y 1 B TRP 172 ? CD2 ? B TRP 172 CD2 
170 1 Y 1 B TRP 172 ? NE1 ? B TRP 172 NE1 
171 1 Y 1 B TRP 172 ? CE2 ? B TRP 172 CE2 
172 1 Y 1 B TRP 172 ? CE3 ? B TRP 172 CE3 
173 1 Y 1 B TRP 172 ? CZ2 ? B TRP 172 CZ2 
174 1 Y 1 B TRP 172 ? CZ3 ? B TRP 172 CZ3 
175 1 Y 1 B TRP 172 ? CH2 ? B TRP 172 CH2 
176 1 Y 1 B LEU 173 ? CG  ? B LEU 173 CG  
177 1 Y 1 B LEU 173 ? CD1 ? B LEU 173 CD1 
178 1 Y 1 B LEU 173 ? CD2 ? B LEU 173 CD2 
179 1 Y 1 B SER 174 ? OG  ? B SER 174 OG  
180 1 Y 1 B LEU 175 ? CG  ? B LEU 175 CG  
181 1 Y 1 B LEU 175 ? CD1 ? B LEU 175 CD1 
182 1 Y 1 B LEU 175 ? CD2 ? B LEU 175 CD2 
183 1 Y 1 B LEU 176 ? CG  ? B LEU 176 CG  
184 1 Y 1 B LEU 176 ? CD1 ? B LEU 176 CD1 
185 1 Y 1 B LEU 176 ? CD2 ? B LEU 176 CD2 
186 1 Y 1 B VAL 177 ? CG1 ? B VAL 177 CG1 
187 1 Y 1 B VAL 177 ? CG2 ? B VAL 177 CG2 
188 1 Y 1 B PHE 179 ? CG  ? B PHE 179 CG  
189 1 Y 1 B PHE 179 ? CD1 ? B PHE 179 CD1 
190 1 Y 1 B PHE 179 ? CD2 ? B PHE 179 CD2 
191 1 Y 1 B PHE 179 ? CE1 ? B PHE 179 CE1 
192 1 Y 1 B PHE 179 ? CE2 ? B PHE 179 CE2 
193 1 Y 1 B PHE 179 ? CZ  ? B PHE 179 CZ  
194 1 Y 1 B VAL 180 ? CG1 ? B VAL 180 CG1 
195 1 Y 1 B VAL 180 ? CG2 ? B VAL 180 CG2 
196 1 Y 1 B GLN 181 ? CG  ? B GLN 181 CG  
197 1 Y 1 B GLN 181 ? CD  ? B GLN 181 CD  
198 1 Y 1 B GLN 181 ? OE1 ? B GLN 181 OE1 
199 1 Y 1 B GLN 181 ? NE2 ? B GLN 181 NE2 
200 1 Y 1 B LEU 186 ? CG  ? B LEU 186 CG  
201 1 Y 1 B LEU 186 ? CD1 ? B LEU 186 CD1 
202 1 Y 1 B LEU 186 ? CD2 ? B LEU 186 CD2 
203 1 Y 1 B TRP 191 ? CG  ? B TRP 191 CG  
204 1 Y 1 B TRP 191 ? CD1 ? B TRP 191 CD1 
205 1 Y 1 B TRP 191 ? CD2 ? B TRP 191 CD2 
206 1 Y 1 B TRP 191 ? NE1 ? B TRP 191 NE1 
207 1 Y 1 B TRP 191 ? CE2 ? B TRP 191 CE2 
208 1 Y 1 B TRP 191 ? CE3 ? B TRP 191 CE3 
209 1 Y 1 B TRP 191 ? CZ2 ? B TRP 191 CZ2 
210 1 Y 1 B TRP 191 ? CZ3 ? B TRP 191 CZ3 
211 1 Y 1 B TRP 191 ? CH2 ? B TRP 191 CH2 
212 1 Y 1 B LEU 213 ? CG  ? B LEU 213 CG  
213 1 Y 1 B LEU 213 ? CD1 ? B LEU 213 CD1 
214 1 Y 1 B LEU 213 ? CD2 ? B LEU 213 CD2 
215 1 Y 1 B LEU 215 ? CG  ? B LEU 215 CG  
216 1 Y 1 B LEU 215 ? CD1 ? B LEU 215 CD1 
217 1 Y 1 B LEU 215 ? CD2 ? B LEU 215 CD2 
218 1 Y 1 B LEU 216 ? CG  ? B LEU 216 CG  
219 1 Y 1 B LEU 216 ? CD1 ? B LEU 216 CD1 
220 1 Y 1 B LEU 216 ? CD2 ? B LEU 216 CD2 
221 1 Y 1 B PHE 220 ? CG  ? B PHE 220 CG  
222 1 Y 1 B PHE 220 ? CD1 ? B PHE 220 CD1 
223 1 Y 1 B PHE 220 ? CD2 ? B PHE 220 CD2 
224 1 Y 1 B PHE 220 ? CE1 ? B PHE 220 CE1 
225 1 Y 1 B PHE 220 ? CE2 ? B PHE 220 CE2 
226 1 Y 1 B PHE 220 ? CZ  ? B PHE 220 CZ  
227 1 Y 1 B CYS 221 ? SG  ? B CYS 221 SG  
228 1 Y 1 B LEU 222 ? CG  ? B LEU 222 CG  
229 1 Y 1 B LEU 222 ? CD1 ? B LEU 222 CD1 
230 1 Y 1 B LEU 222 ? CD2 ? B LEU 222 CD2 
231 1 Y 1 B TRP 223 ? CG  ? B TRP 223 CG  
232 1 Y 1 B TRP 223 ? CD1 ? B TRP 223 CD1 
233 1 Y 1 B TRP 223 ? CD2 ? B TRP 223 CD2 
234 1 Y 1 B TRP 223 ? NE1 ? B TRP 223 NE1 
235 1 Y 1 B TRP 223 ? CE2 ? B TRP 223 CE2 
236 1 Y 1 B TRP 223 ? CE3 ? B TRP 223 CE3 
237 1 Y 1 B TRP 223 ? CZ2 ? B TRP 223 CZ2 
238 1 Y 1 B TRP 223 ? CZ3 ? B TRP 223 CZ3 
239 1 Y 1 B TRP 223 ? CH2 ? B TRP 223 CH2 
240 1 Y 1 B VAL 224 ? CG1 ? B VAL 224 CG1 
241 1 Y 1 B VAL 224 ? CG2 ? B VAL 224 CG2 
242 1 Y 1 B TYR 225 ? CG  ? B TYR 225 CG  
243 1 Y 1 B TYR 225 ? CD1 ? B TYR 225 CD1 
244 1 Y 1 B TYR 225 ? CD2 ? B TYR 225 CD2 
245 1 Y 1 B TYR 225 ? CE1 ? B TYR 225 CE1 
246 1 Y 1 B TYR 225 ? CE2 ? B TYR 225 CE2 
247 1 Y 1 B TYR 225 ? CZ  ? B TYR 225 CZ  
248 1 Y 1 B TYR 225 ? OH  ? B TYR 225 OH  
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9IYX 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_struct.entry_id                     9IYX 
_struct.title                        'Structure of HBV surface antigen determined in recombinant spherical subviral particle' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9IYX 
_struct_keywords.text            'HBV, HBsAg, VIRAL PROTEIN' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    V9P415_HBV 
_struct_ref.pdbx_db_accession          V9P415 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MENITSGFLGPLLVLQAGFFLLTRILTIPQSLDSWWTSLNFLGGTTVCLGQNSQSPTSNHSPTSCPPTCPGYRWMCLRRF
IIFLFILLLCLIFLLVLLDYQGMLPVCPLIPGSSTTSTGPCRTCMTTAQGTSMYPSCCCTKPSDGNCTCIPIPSSWAFGK
FLWEWASARFSWLSLLVPFVQWFVGLSPTVWLSVIWMMWYWGPSLYSILSPFLPLLPIFFCLWVYI
;
_struct_ref.pdbx_align_begin           164 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9IYX A 1 ? 226 ? V9P415 164 ? 389 ? 1 226 
2 1 9IYX B 1 ? 226 ? V9P415 164 ? 389 ? 1 226 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASN A 3   ? LEU A 26  ? ASN A 3   LEU A 26  1 ? 24 
HELX_P HELX_P2  AA2 THR A 27  ? PHE A 41  ? THR A 27  PHE A 41  1 ? 15 
HELX_P HELX_P3  AA3 PRO A 70  ? ASP A 99  ? PRO A 70  ASP A 99  1 ? 30 
HELX_P HELX_P4  AA4 TYR A 100 ? GLY A 102 ? TYR A 100 GLY A 102 5 ? 3  
HELX_P HELX_P5  AA5 TRP A 156 ? PHE A 170 ? TRP A 156 PHE A 170 1 ? 15 
HELX_P HELX_P6  AA6 PHE A 170 ? LEU A 186 ? PHE A 170 LEU A 186 1 ? 17 
HELX_P HELX_P7  AA7 SER A 187 ? SER A 207 ? SER A 187 SER A 207 1 ? 21 
HELX_P HELX_P8  AA8 ILE A 208 ? SER A 210 ? ILE A 208 SER A 210 5 ? 3  
HELX_P HELX_P9  AA9 PRO A 211 ? ILE A 226 ? PRO A 211 ILE A 226 1 ? 16 
HELX_P HELX_P10 AB1 GLY B 10  ? PHE B 41  ? GLY B 10  PHE B 41  1 ? 32 
HELX_P HELX_P11 AB2 CYS B 69  ? GLY B 102 ? CYS B 69  GLY B 102 1 ? 34 
HELX_P HELX_P12 AB3 TRP B 156 ? SER B 171 ? TRP B 156 SER B 171 1 ? 16 
HELX_P HELX_P13 AB4 TRP B 172 ? LEU B 186 ? TRP B 172 LEU B 186 1 ? 15 
HELX_P HELX_P14 AB5 THR B 189 ? SER B 210 ? THR B 189 SER B 210 1 ? 22 
HELX_P HELX_P15 AB6 PRO B 211 ? LEU B 213 ? PRO B 211 LEU B 213 5 ? 3  
HELX_P HELX_P16 AB7 PRO B 214 ? ILE B 226 ? PRO B 214 ILE B 226 1 ? 13 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1 metalc ? ? A CYS 48 SG  ? ? ? 1_555 C ZN . ZN ? ? A CYS 48 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.316 ? ? 
metalc2 metalc ? ? A HIS 60 NE2 ? ? ? 1_555 C ZN . ZN ? ? A HIS 60 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.053 ? ? 
metalc3 metalc ? ? A CYS 65 SG  ? ? ? 1_555 C ZN . ZN ? ? A CYS 65 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.315 ? ? 
metalc4 metalc ? ? A CYS 69 SG  ? ? ? 1_555 C ZN . ZN ? ? A CYS 69 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.312 ? ? 
metalc5 metalc ? ? B CYS 48 SG  ? ? ? 1_555 D ZN . ZN ? ? B CYS 48 B ZN 301  1_555 ? ? ? ? ? ? ? 2.316 ? ? 
metalc6 metalc ? ? B HIS 60 NE2 ? ? ? 1_555 D ZN . ZN ? ? B HIS 60 B ZN 301  1_555 ? ? ? ? ? ? ? 2.042 ? ? 
metalc7 metalc ? ? B CYS 65 SG  ? ? ? 1_555 D ZN . ZN ? ? B CYS 65 B ZN 301  1_555 ? ? ? ? ? ? ? 2.327 ? ? 
metalc8 metalc ? ? B CYS 69 SG  ? ? ? 1_555 D ZN . ZN ? ? B CYS 69 B ZN 301  1_555 ? ? ? ? ? ? ? 2.320 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  SG  ? A CYS 48 ? A CYS 48 ? 1_555 ZN ? C ZN . ? A ZN 1001 ? 1_555 NE2 ? A HIS 60 ? A HIS 60 ? 1_555 127.7 ? 
2  SG  ? A CYS 48 ? A CYS 48 ? 1_555 ZN ? C ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 65 ? A CYS 65 ? 1_555 114.5 ? 
3  NE2 ? A HIS 60 ? A HIS 60 ? 1_555 ZN ? C ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 65 ? A CYS 65 ? 1_555 97.3  ? 
4  SG  ? A CYS 48 ? A CYS 48 ? 1_555 ZN ? C ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 69 ? A CYS 69 ? 1_555 110.6 ? 
5  NE2 ? A HIS 60 ? A HIS 60 ? 1_555 ZN ? C ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 69 ? A CYS 69 ? 1_555 94.1  ? 
6  SG  ? A CYS 65 ? A CYS 65 ? 1_555 ZN ? C ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 69 ? A CYS 69 ? 1_555 110.4 ? 
7  SG  ? B CYS 48 ? B CYS 48 ? 1_555 ZN ? D ZN . ? B ZN 301  ? 1_555 NE2 ? B HIS 60 ? B HIS 60 ? 1_555 121.1 ? 
8  SG  ? B CYS 48 ? B CYS 48 ? 1_555 ZN ? D ZN . ? B ZN 301  ? 1_555 SG  ? B CYS 65 ? B CYS 65 ? 1_555 116.7 ? 
9  NE2 ? B HIS 60 ? B HIS 60 ? 1_555 ZN ? D ZN . ? B ZN 301  ? 1_555 SG  ? B CYS 65 ? B CYS 65 ? 1_555 113.5 ? 
10 SG  ? B CYS 48 ? B CYS 48 ? 1_555 ZN ? D ZN . ? B ZN 301  ? 1_555 SG  ? B CYS 69 ? B CYS 69 ? 1_555 111.0 ? 
11 NE2 ? B HIS 60 ? B HIS 60 ? 1_555 ZN ? D ZN . ? B ZN 301  ? 1_555 SG  ? B CYS 69 ? B CYS 69 ? 1_555 67.2  ? 
12 SG  ? B CYS 65 ? B CYS 65 ? 1_555 ZN ? D ZN . ? B ZN 301  ? 1_555 SG  ? B CYS 69 ? B CYS 69 ? 1_555 118.0 ? 
# 
_pdbx_entry_details.entry_id                   9IYX 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 O   A TRP 35  ? ? OG  A SER 38  ? ? 2.13 
2 1 OE1 B GLN 30  ? ? NH2 B ARG 79  ? ? 2.14 
3 1 O   A TRP 201 ? ? N   A LEU 205 ? ? 2.16 
4 1 O   A PRO 62  ? ? NH2 A ARG 78  ? ? 2.19 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 THR A 46  ? ? 66.06 -161.99 
2 1 SER B 171 ? ? 74.87 -5.28   
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9IYX 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    9IYX 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.6 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               1590360 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.41 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'HBV surface antigen dimer' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        9IYX 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             1500 
_em_imaging.nominal_defocus_max             1800 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              9IYX 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9IYX 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A MET 1   ? A MET 1   
2   1 Y 1 A GLU 2   ? A GLU 2   
3   1 Y 1 A GLN 51  ? A GLN 51  
4   1 Y 1 A ASN 52  ? A ASN 52  
5   1 Y 1 A SER 53  ? A SER 53  
6   1 Y 1 A GLN 54  ? A GLN 54  
7   1 Y 1 A SER 55  ? A SER 55  
8   1 Y 1 A PRO 56  ? A PRO 56  
9   1 Y 1 A PRO 111 ? A PRO 111 
10  1 Y 1 A GLY 112 ? A GLY 112 
11  1 Y 1 A SER 113 ? A SER 113 
12  1 Y 1 A SER 114 ? A SER 114 
13  1 Y 1 A THR 115 ? A THR 115 
14  1 Y 1 A THR 116 ? A THR 116 
15  1 Y 1 A SER 117 ? A SER 117 
16  1 Y 1 A THR 118 ? A THR 118 
17  1 Y 1 A GLY 119 ? A GLY 119 
18  1 Y 1 A PRO 120 ? A PRO 120 
19  1 Y 1 A CYS 121 ? A CYS 121 
20  1 Y 1 A ARG 122 ? A ARG 122 
21  1 Y 1 A THR 123 ? A THR 123 
22  1 Y 1 A CYS 124 ? A CYS 124 
23  1 Y 1 A MET 125 ? A MET 125 
24  1 Y 1 A THR 126 ? A THR 126 
25  1 Y 1 A THR 127 ? A THR 127 
26  1 Y 1 A ALA 128 ? A ALA 128 
27  1 Y 1 A GLN 129 ? A GLN 129 
28  1 Y 1 A GLY 130 ? A GLY 130 
29  1 Y 1 A THR 131 ? A THR 131 
30  1 Y 1 A SER 132 ? A SER 132 
31  1 Y 1 A MET 133 ? A MET 133 
32  1 Y 1 A TYR 134 ? A TYR 134 
33  1 Y 1 A PRO 135 ? A PRO 135 
34  1 Y 1 A SER 136 ? A SER 136 
35  1 Y 1 A CYS 137 ? A CYS 137 
36  1 Y 1 A CYS 138 ? A CYS 138 
37  1 Y 1 A CYS 139 ? A CYS 139 
38  1 Y 1 A THR 140 ? A THR 140 
39  1 Y 1 A LYS 141 ? A LYS 141 
40  1 Y 1 A PRO 142 ? A PRO 142 
41  1 Y 1 A SER 143 ? A SER 143 
42  1 Y 1 A ASP 144 ? A ASP 144 
43  1 Y 1 A GLY 145 ? A GLY 145 
44  1 Y 1 A ASN 146 ? A ASN 146 
45  1 Y 1 A CYS 147 ? A CYS 147 
46  1 Y 1 A THR 148 ? A THR 148 
47  1 Y 1 A CYS 149 ? A CYS 149 
48  1 Y 1 B MET 1   ? B MET 1   
49  1 Y 1 B GLU 2   ? B GLU 2   
50  1 Y 1 B ASN 3   ? B ASN 3   
51  1 Y 1 B ILE 4   ? B ILE 4   
52  1 Y 1 B THR 5   ? B THR 5   
53  1 Y 1 B SER 6   ? B SER 6   
54  1 Y 1 B GLY 7   ? B GLY 7   
55  1 Y 1 B PHE 8   ? B PHE 8   
56  1 Y 1 B GLN 51  ? B GLN 51  
57  1 Y 1 B ASN 52  ? B ASN 52  
58  1 Y 1 B SER 53  ? B SER 53  
59  1 Y 1 B GLN 54  ? B GLN 54  
60  1 Y 1 B SER 55  ? B SER 55  
61  1 Y 1 B PRO 56  ? B PRO 56  
62  1 Y 1 B THR 57  ? B THR 57  
63  1 Y 1 B PRO 111 ? B PRO 111 
64  1 Y 1 B GLY 112 ? B GLY 112 
65  1 Y 1 B SER 113 ? B SER 113 
66  1 Y 1 B SER 114 ? B SER 114 
67  1 Y 1 B THR 115 ? B THR 115 
68  1 Y 1 B THR 116 ? B THR 116 
69  1 Y 1 B SER 117 ? B SER 117 
70  1 Y 1 B THR 118 ? B THR 118 
71  1 Y 1 B GLY 119 ? B GLY 119 
72  1 Y 1 B PRO 120 ? B PRO 120 
73  1 Y 1 B CYS 121 ? B CYS 121 
74  1 Y 1 B ARG 122 ? B ARG 122 
75  1 Y 1 B THR 123 ? B THR 123 
76  1 Y 1 B CYS 124 ? B CYS 124 
77  1 Y 1 B MET 125 ? B MET 125 
78  1 Y 1 B THR 126 ? B THR 126 
79  1 Y 1 B THR 127 ? B THR 127 
80  1 Y 1 B ALA 128 ? B ALA 128 
81  1 Y 1 B GLN 129 ? B GLN 129 
82  1 Y 1 B GLY 130 ? B GLY 130 
83  1 Y 1 B THR 131 ? B THR 131 
84  1 Y 1 B SER 132 ? B SER 132 
85  1 Y 1 B MET 133 ? B MET 133 
86  1 Y 1 B TYR 134 ? B TYR 134 
87  1 Y 1 B PRO 135 ? B PRO 135 
88  1 Y 1 B SER 136 ? B SER 136 
89  1 Y 1 B CYS 137 ? B CYS 137 
90  1 Y 1 B CYS 138 ? B CYS 138 
91  1 Y 1 B CYS 139 ? B CYS 139 
92  1 Y 1 B THR 140 ? B THR 140 
93  1 Y 1 B LYS 141 ? B LYS 141 
94  1 Y 1 B PRO 142 ? B PRO 142 
95  1 Y 1 B SER 143 ? B SER 143 
96  1 Y 1 B ASP 144 ? B ASP 144 
97  1 Y 1 B GLY 145 ? B GLY 145 
98  1 Y 1 B ASN 146 ? B ASN 146 
99  1 Y 1 B CYS 147 ? B CYS 147 
100 1 Y 1 B THR 148 ? B THR 148 
101 1 Y 1 B CYS 149 ? B CYS 149 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CYS N    N  N N 74  
CYS CA   C  N R 75  
CYS C    C  N N 76  
CYS O    O  N N 77  
CYS CB   C  N N 78  
CYS SG   S  N N 79  
CYS OXT  O  N N 80  
CYS H    H  N N 81  
CYS H2   H  N N 82  
CYS HA   H  N N 83  
CYS HB2  H  N N 84  
CYS HB3  H  N N 85  
CYS HG   H  N N 86  
CYS HXT  H  N N 87  
GLN N    N  N N 88  
GLN CA   C  N S 89  
GLN C    C  N N 90  
GLN O    O  N N 91  
GLN CB   C  N N 92  
GLN CG   C  N N 93  
GLN CD   C  N N 94  
GLN OE1  O  N N 95  
GLN NE2  N  N N 96  
GLN OXT  O  N N 97  
GLN H    H  N N 98  
GLN H2   H  N N 99  
GLN HA   H  N N 100 
GLN HB2  H  N N 101 
GLN HB3  H  N N 102 
GLN HG2  H  N N 103 
GLN HG3  H  N N 104 
GLN HE21 H  N N 105 
GLN HE22 H  N N 106 
GLN HXT  H  N N 107 
GLU N    N  N N 108 
GLU CA   C  N S 109 
GLU C    C  N N 110 
GLU O    O  N N 111 
GLU CB   C  N N 112 
GLU CG   C  N N 113 
GLU CD   C  N N 114 
GLU OE1  O  N N 115 
GLU OE2  O  N N 116 
GLU OXT  O  N N 117 
GLU H    H  N N 118 
GLU H2   H  N N 119 
GLU HA   H  N N 120 
GLU HB2  H  N N 121 
GLU HB3  H  N N 122 
GLU HG2  H  N N 123 
GLU HG3  H  N N 124 
GLU HE2  H  N N 125 
GLU HXT  H  N N 126 
GLY N    N  N N 127 
GLY CA   C  N N 128 
GLY C    C  N N 129 
GLY O    O  N N 130 
GLY OXT  O  N N 131 
GLY H    H  N N 132 
GLY H2   H  N N 133 
GLY HA2  H  N N 134 
GLY HA3  H  N N 135 
GLY HXT  H  N N 136 
HIS N    N  N N 137 
HIS CA   C  N S 138 
HIS C    C  N N 139 
HIS O    O  N N 140 
HIS CB   C  N N 141 
HIS CG   C  Y N 142 
HIS ND1  N  Y N 143 
HIS CD2  C  Y N 144 
HIS CE1  C  Y N 145 
HIS NE2  N  Y N 146 
HIS OXT  O  N N 147 
HIS H    H  N N 148 
HIS H2   H  N N 149 
HIS HA   H  N N 150 
HIS HB2  H  N N 151 
HIS HB3  H  N N 152 
HIS HD1  H  N N 153 
HIS HD2  H  N N 154 
HIS HE1  H  N N 155 
HIS HE2  H  N N 156 
HIS HXT  H  N N 157 
ILE N    N  N N 158 
ILE CA   C  N S 159 
ILE C    C  N N 160 
ILE O    O  N N 161 
ILE CB   C  N S 162 
ILE CG1  C  N N 163 
ILE CG2  C  N N 164 
ILE CD1  C  N N 165 
ILE OXT  O  N N 166 
ILE H    H  N N 167 
ILE H2   H  N N 168 
ILE HA   H  N N 169 
ILE HB   H  N N 170 
ILE HG12 H  N N 171 
ILE HG13 H  N N 172 
ILE HG21 H  N N 173 
ILE HG22 H  N N 174 
ILE HG23 H  N N 175 
ILE HD11 H  N N 176 
ILE HD12 H  N N 177 
ILE HD13 H  N N 178 
ILE HXT  H  N N 179 
LEU N    N  N N 180 
LEU CA   C  N S 181 
LEU C    C  N N 182 
LEU O    O  N N 183 
LEU CB   C  N N 184 
LEU CG   C  N N 185 
LEU CD1  C  N N 186 
LEU CD2  C  N N 187 
LEU OXT  O  N N 188 
LEU H    H  N N 189 
LEU H2   H  N N 190 
LEU HA   H  N N 191 
LEU HB2  H  N N 192 
LEU HB3  H  N N 193 
LEU HG   H  N N 194 
LEU HD11 H  N N 195 
LEU HD12 H  N N 196 
LEU HD13 H  N N 197 
LEU HD21 H  N N 198 
LEU HD22 H  N N 199 
LEU HD23 H  N N 200 
LEU HXT  H  N N 201 
LYS N    N  N N 202 
LYS CA   C  N S 203 
LYS C    C  N N 204 
LYS O    O  N N 205 
LYS CB   C  N N 206 
LYS CG   C  N N 207 
LYS CD   C  N N 208 
LYS CE   C  N N 209 
LYS NZ   N  N N 210 
LYS OXT  O  N N 211 
LYS H    H  N N 212 
LYS H2   H  N N 213 
LYS HA   H  N N 214 
LYS HB2  H  N N 215 
LYS HB3  H  N N 216 
LYS HG2  H  N N 217 
LYS HG3  H  N N 218 
LYS HD2  H  N N 219 
LYS HD3  H  N N 220 
LYS HE2  H  N N 221 
LYS HE3  H  N N 222 
LYS HZ1  H  N N 223 
LYS HZ2  H  N N 224 
LYS HZ3  H  N N 225 
LYS HXT  H  N N 226 
MET N    N  N N 227 
MET CA   C  N S 228 
MET C    C  N N 229 
MET O    O  N N 230 
MET CB   C  N N 231 
MET CG   C  N N 232 
MET SD   S  N N 233 
MET CE   C  N N 234 
MET OXT  O  N N 235 
MET H    H  N N 236 
MET H2   H  N N 237 
MET HA   H  N N 238 
MET HB2  H  N N 239 
MET HB3  H  N N 240 
MET HG2  H  N N 241 
MET HG3  H  N N 242 
MET HE1  H  N N 243 
MET HE2  H  N N 244 
MET HE3  H  N N 245 
MET HXT  H  N N 246 
PHE N    N  N N 247 
PHE CA   C  N S 248 
PHE C    C  N N 249 
PHE O    O  N N 250 
PHE CB   C  N N 251 
PHE CG   C  Y N 252 
PHE CD1  C  Y N 253 
PHE CD2  C  Y N 254 
PHE CE1  C  Y N 255 
PHE CE2  C  Y N 256 
PHE CZ   C  Y N 257 
PHE OXT  O  N N 258 
PHE H    H  N N 259 
PHE H2   H  N N 260 
PHE HA   H  N N 261 
PHE HB2  H  N N 262 
PHE HB3  H  N N 263 
PHE HD1  H  N N 264 
PHE HD2  H  N N 265 
PHE HE1  H  N N 266 
PHE HE2  H  N N 267 
PHE HZ   H  N N 268 
PHE HXT  H  N N 269 
PRO N    N  N N 270 
PRO CA   C  N S 271 
PRO C    C  N N 272 
PRO O    O  N N 273 
PRO CB   C  N N 274 
PRO CG   C  N N 275 
PRO CD   C  N N 276 
PRO OXT  O  N N 277 
PRO H    H  N N 278 
PRO HA   H  N N 279 
PRO HB2  H  N N 280 
PRO HB3  H  N N 281 
PRO HG2  H  N N 282 
PRO HG3  H  N N 283 
PRO HD2  H  N N 284 
PRO HD3  H  N N 285 
PRO HXT  H  N N 286 
SER N    N  N N 287 
SER CA   C  N S 288 
SER C    C  N N 289 
SER O    O  N N 290 
SER CB   C  N N 291 
SER OG   O  N N 292 
SER OXT  O  N N 293 
SER H    H  N N 294 
SER H2   H  N N 295 
SER HA   H  N N 296 
SER HB2  H  N N 297 
SER HB3  H  N N 298 
SER HG   H  N N 299 
SER HXT  H  N N 300 
THR N    N  N N 301 
THR CA   C  N S 302 
THR C    C  N N 303 
THR O    O  N N 304 
THR CB   C  N R 305 
THR OG1  O  N N 306 
THR CG2  C  N N 307 
THR OXT  O  N N 308 
THR H    H  N N 309 
THR H2   H  N N 310 
THR HA   H  N N 311 
THR HB   H  N N 312 
THR HG1  H  N N 313 
THR HG21 H  N N 314 
THR HG22 H  N N 315 
THR HG23 H  N N 316 
THR HXT  H  N N 317 
TRP N    N  N N 318 
TRP CA   C  N S 319 
TRP C    C  N N 320 
TRP O    O  N N 321 
TRP CB   C  N N 322 
TRP CG   C  Y N 323 
TRP CD1  C  Y N 324 
TRP CD2  C  Y N 325 
TRP NE1  N  Y N 326 
TRP CE2  C  Y N 327 
TRP CE3  C  Y N 328 
TRP CZ2  C  Y N 329 
TRP CZ3  C  Y N 330 
TRP CH2  C  Y N 331 
TRP OXT  O  N N 332 
TRP H    H  N N 333 
TRP H2   H  N N 334 
TRP HA   H  N N 335 
TRP HB2  H  N N 336 
TRP HB3  H  N N 337 
TRP HD1  H  N N 338 
TRP HE1  H  N N 339 
TRP HE3  H  N N 340 
TRP HZ2  H  N N 341 
TRP HZ3  H  N N 342 
TRP HH2  H  N N 343 
TRP HXT  H  N N 344 
TYR N    N  N N 345 
TYR CA   C  N S 346 
TYR C    C  N N 347 
TYR O    O  N N 348 
TYR CB   C  N N 349 
TYR CG   C  Y N 350 
TYR CD1  C  Y N 351 
TYR CD2  C  Y N 352 
TYR CE1  C  Y N 353 
TYR CE2  C  Y N 354 
TYR CZ   C  Y N 355 
TYR OH   O  N N 356 
TYR OXT  O  N N 357 
TYR H    H  N N 358 
TYR H2   H  N N 359 
TYR HA   H  N N 360 
TYR HB2  H  N N 361 
TYR HB3  H  N N 362 
TYR HD1  H  N N 363 
TYR HD2  H  N N 364 
TYR HE1  H  N N 365 
TYR HE2  H  N N 366 
TYR HH   H  N N 367 
TYR HXT  H  N N 368 
VAL N    N  N N 369 
VAL CA   C  N S 370 
VAL C    C  N N 371 
VAL O    O  N N 372 
VAL CB   C  N N 373 
VAL CG1  C  N N 374 
VAL CG2  C  N N 375 
VAL OXT  O  N N 376 
VAL H    H  N N 377 
VAL H2   H  N N 378 
VAL HA   H  N N 379 
VAL HB   H  N N 380 
VAL HG11 H  N N 381 
VAL HG12 H  N N 382 
VAL HG13 H  N N 383 
VAL HG21 H  N N 384 
VAL HG22 H  N N 385 
VAL HG23 H  N N 386 
VAL HXT  H  N N 387 
ZN  ZN   ZN N N 388 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
VAL N   CA   sing N N 356 
VAL N   H    sing N N 357 
VAL N   H2   sing N N 358 
VAL CA  C    sing N N 359 
VAL CA  CB   sing N N 360 
VAL CA  HA   sing N N 361 
VAL C   O    doub N N 362 
VAL C   OXT  sing N N 363 
VAL CB  CG1  sing N N 364 
VAL CB  CG2  sing N N 365 
VAL CB  HB   sing N N 366 
VAL CG1 HG11 sing N N 367 
VAL CG1 HG12 sing N N 368 
VAL CG1 HG13 sing N N 369 
VAL CG2 HG21 sing N N 370 
VAL CG2 HG22 sing N N 371 
VAL CG2 HG23 sing N N 372 
VAL OXT HXT  sing N N 373 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-07-31 
_em_admin.deposition_site    PDBJ 
_em_admin.entry_id           9IYX 
_em_admin.last_update        2025-01-15 
_em_admin.map_release_date   2025-01-15 
_em_admin.title              'Structure of HBV surface antigen determined in recombinant spherical subviral particle' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          1219353 
_em_entity_assembly_naturalsource.organism             'HBV genotype D3' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          9606 
_em_entity_assembly_recombinant.organism             'Homo sapiens' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         50 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 BIOQUANTUM (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'       ? 1  1 ? ? ? ? 
'IMAGE ACQUISITION'        ? 2  ? ? 1 ? ? 
MASKING                    ? 3  ? ? ? ? ? 
'CTF CORRECTION'           ? 4  1 ? ? ? ? 
'LAYERLINE INDEXING'       ? 5  ? ? ? ? ? 
'DIFFRACTION INDEXING'     ? 6  ? ? ? ? ? 
'MODEL FITTING'            ? 7  ? ? ? ? ? 
'MODEL REFINEMENT'         ? 8  ? ? ? ? ? 
OTHER                      ? 9  ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT' ? 10 1 ? ? ? ? 
'FINAL EULER ASSIGNMENT'   ? 11 1 ? ? ? ? 
CLASSIFICATION             ? 12 1 ? ? ? ? 
RECONSTRUCTION             ? 13 1 ? ? ? ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           31821091 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    9IYX 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
N  
O  
S  
ZN 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . ASN A 1 3   ? 109.162 195.387 161.662 1.00 49.17 ? 3    ASN A N   1 
ATOM   2    C  CA  . ASN A 1 3   ? 108.947 194.271 162.576 1.00 49.17 ? 3    ASN A CA  1 
ATOM   3    C  C   . ASN A 1 3   ? 109.717 193.037 162.116 1.00 49.17 ? 3    ASN A C   1 
ATOM   4    O  O   . ASN A 1 3   ? 110.787 192.733 162.641 1.00 49.17 ? 3    ASN A O   1 
ATOM   5    C  CB  . ASN A 1 3   ? 107.456 193.949 162.686 1.00 49.17 ? 3    ASN A CB  1 
ATOM   6    N  N   . ILE A 1 4   ? 109.163 192.327 161.131 1.00 48.84 ? 4    ILE A N   1 
ATOM   7    C  CA  . ILE A 1 4   ? 109.816 191.121 160.629 1.00 48.84 ? 4    ILE A CA  1 
ATOM   8    C  C   . ILE A 1 4   ? 111.166 191.464 160.010 1.00 48.84 ? 4    ILE A C   1 
ATOM   9    O  O   . ILE A 1 4   ? 112.172 190.793 160.270 1.00 48.84 ? 4    ILE A O   1 
ATOM   10   C  CB  . ILE A 1 4   ? 108.896 190.389 159.633 1.00 48.84 ? 4    ILE A CB  1 
ATOM   11   C  CG1 . ILE A 1 4   ? 108.566 191.279 158.427 1.00 48.84 ? 4    ILE A CG1 1 
ATOM   12   C  CG2 . ILE A 1 4   ? 107.620 189.943 160.332 1.00 48.84 ? 4    ILE A CG2 1 
ATOM   13   C  CD1 . ILE A 1 4   ? 107.691 190.604 157.387 1.00 48.84 ? 4    ILE A CD1 1 
ATOM   14   N  N   . THR A 1 5   ? 111.217 192.526 159.202 1.00 49.99 ? 5    THR A N   1 
ATOM   15   C  CA  . THR A 1 5   ? 112.475 192.937 158.588 1.00 49.99 ? 5    THR A CA  1 
ATOM   16   C  C   . THR A 1 5   ? 113.504 193.303 159.652 1.00 49.99 ? 5    THR A C   1 
ATOM   17   O  O   . THR A 1 5   ? 114.576 192.695 159.736 1.00 49.99 ? 5    THR A O   1 
ATOM   18   C  CB  . THR A 1 5   ? 112.234 194.115 157.640 1.00 49.99 ? 5    THR A CB  1 
ATOM   19   O  OG1 . THR A 1 5   ? 111.305 193.729 156.617 1.00 49.99 ? 5    THR A OG1 1 
ATOM   20   C  CG2 . THR A 1 5   ? 113.538 194.568 156.996 1.00 49.99 ? 5    THR A CG2 1 
ATOM   21   N  N   . SER A 1 6   ? 113.190 194.305 160.476 1.00 48.76 ? 6    SER A N   1 
ATOM   22   C  CA  . SER A 1 6   ? 114.102 194.691 161.547 1.00 48.76 ? 6    SER A CA  1 
ATOM   23   C  C   . SER A 1 6   ? 114.273 193.570 162.561 1.00 48.76 ? 6    SER A C   1 
ATOM   24   O  O   . SER A 1 6   ? 115.365 193.397 163.116 1.00 48.76 ? 6    SER A O   1 
ATOM   25   C  CB  . SER A 1 6   ? 113.597 195.957 162.237 1.00 48.76 ? 6    SER A CB  1 
ATOM   26   N  N   . GLY A 1 7   ? 113.211 192.804 162.819 1.00 49.56 ? 7    GLY A N   1 
ATOM   27   C  CA  . GLY A 1 7   ? 113.324 191.702 163.760 1.00 49.56 ? 7    GLY A CA  1 
ATOM   28   C  C   . GLY A 1 7   ? 114.374 190.694 163.338 1.00 49.56 ? 7    GLY A C   1 
ATOM   29   O  O   . GLY A 1 7   ? 115.118 190.167 164.168 1.00 49.56 ? 7    GLY A O   1 
ATOM   30   N  N   . PHE A 1 8   ? 114.440 190.402 162.037 1.00 46.36 ? 8    PHE A N   1 
ATOM   31   C  CA  . PHE A 1 8   ? 115.470 189.498 161.537 1.00 46.36 ? 8    PHE A CA  1 
ATOM   32   C  C   . PHE A 1 8   ? 116.824 190.193 161.468 1.00 46.36 ? 8    PHE A C   1 
ATOM   33   O  O   . PHE A 1 8   ? 117.856 189.587 161.776 1.00 46.36 ? 8    PHE A O   1 
ATOM   34   C  CB  . PHE A 1 8   ? 115.074 188.966 160.160 1.00 46.36 ? 8    PHE A CB  1 
ATOM   35   C  CG  . PHE A 1 8   ? 113.841 188.102 160.170 1.00 46.36 ? 8    PHE A CG  1 
ATOM   36   C  CD1 . PHE A 1 8   ? 113.602 187.213 161.206 1.00 46.36 ? 8    PHE A CD1 1 
ATOM   37   C  CD2 . PHE A 1 8   ? 112.920 188.181 159.138 1.00 46.36 ? 8    PHE A CD2 1 
ATOM   38   C  CE1 . PHE A 1 8   ? 112.467 186.424 161.212 1.00 46.36 ? 8    PHE A CE1 1 
ATOM   39   C  CE2 . PHE A 1 8   ? 111.784 187.394 159.140 1.00 46.36 ? 8    PHE A CE2 1 
ATOM   40   C  CZ  . PHE A 1 8   ? 111.558 186.515 160.178 1.00 46.36 ? 8    PHE A CZ  1 
ATOM   41   N  N   . LEU A 1 9   ? 116.840 191.468 161.071 1.00 43.09 ? 9    LEU A N   1 
ATOM   42   C  CA  . LEU A 1 9   ? 118.106 192.166 160.877 1.00 43.09 ? 9    LEU A CA  1 
ATOM   43   C  C   . LEU A 1 9   ? 118.862 192.344 162.186 1.00 43.09 ? 9    LEU A C   1 
ATOM   44   O  O   . LEU A 1 9   ? 120.096 192.287 162.198 1.00 43.09 ? 9    LEU A O   1 
ATOM   45   C  CB  . LEU A 1 9   ? 117.858 193.525 160.221 1.00 43.09 ? 9    LEU A CB  1 
ATOM   46   C  CG  . LEU A 1 9   ? 119.091 194.235 159.657 1.00 43.09 ? 9    LEU A CG  1 
ATOM   47   C  CD1 . LEU A 1 9   ? 118.721 195.043 158.421 1.00 43.09 ? 9    LEU A CD1 1 
ATOM   48   C  CD2 . LEU A 1 9   ? 119.740 195.130 160.704 1.00 43.09 ? 9    LEU A CD2 1 
ATOM   49   N  N   . GLY A 1 10  ? 118.151 192.572 163.289 1.00 45.88 ? 10   GLY A N   1 
ATOM   50   C  CA  . GLY A 1 10  ? 118.785 192.814 164.564 1.00 45.88 ? 10   GLY A CA  1 
ATOM   51   C  C   . GLY A 1 10  ? 119.750 191.712 164.952 1.00 45.88 ? 10   GLY A C   1 
ATOM   52   O  O   . GLY A 1 10  ? 120.968 191.916 165.030 1.00 45.88 ? 10   GLY A O   1 
ATOM   53   N  N   . PRO A 1 11  ? 119.221 190.515 165.216 1.00 40.75 ? 11   PRO A N   1 
ATOM   54   C  CA  . PRO A 1 11  ? 120.121 189.387 165.498 1.00 40.75 ? 11   PRO A CA  1 
ATOM   55   C  C   . PRO A 1 11  ? 121.113 189.138 164.380 1.00 40.75 ? 11   PRO A C   1 
ATOM   56   O  O   . PRO A 1 11  ? 122.293 188.903 164.656 1.00 40.75 ? 11   PRO A O   1 
ATOM   57   C  CB  . PRO A 1 11  ? 119.155 188.209 165.687 1.00 40.75 ? 11   PRO A CB  1 
ATOM   58   C  CG  . PRO A 1 11  ? 117.864 188.838 166.084 1.00 40.75 ? 11   PRO A CG  1 
ATOM   59   C  CD  . PRO A 1 11  ? 117.805 190.134 165.333 1.00 40.75 ? 11   PRO A CD  1 
ATOM   60   N  N   . LEU A 1 12  ? 120.678 189.219 163.119 1.00 36.56 ? 12   LEU A N   1 
ATOM   61   C  CA  . LEU A 1 12  ? 121.605 189.023 162.009 1.00 36.56 ? 12   LEU A CA  1 
ATOM   62   C  C   . LEU A 1 12  ? 122.631 190.147 161.943 1.00 36.56 ? 12   LEU A C   1 
ATOM   63   O  O   . LEU A 1 12  ? 123.781 189.927 161.544 1.00 36.56 ? 12   LEU A O   1 
ATOM   64   C  CB  . LEU A 1 12  ? 120.842 188.921 160.690 1.00 36.56 ? 12   LEU A CB  1 
ATOM   65   C  CG  . LEU A 1 12  ? 121.718 188.671 159.461 1.00 36.56 ? 12   LEU A CG  1 
ATOM   66   C  CD1 . LEU A 1 12  ? 122.453 187.348 159.579 1.00 36.56 ? 12   LEU A CD1 1 
ATOM   67   C  CD2 . LEU A 1 12  ? 120.879 188.704 158.196 1.00 36.56 ? 12   LEU A CD2 1 
ATOM   68   N  N   . LEU A 1 13  ? 122.233 191.362 162.321 1.00 34.32 ? 13   LEU A N   1 
ATOM   69   C  CA  . LEU A 1 13  ? 123.207 192.441 162.428 1.00 34.32 ? 13   LEU A CA  1 
ATOM   70   C  C   . LEU A 1 13  ? 124.267 192.098 163.465 1.00 34.32 ? 13   LEU A C   1 
ATOM   71   O  O   . LEU A 1 13  ? 125.461 192.328 163.245 1.00 34.32 ? 13   LEU A O   1 
ATOM   72   C  CB  . LEU A 1 13  ? 122.508 193.752 162.785 1.00 34.32 ? 13   LEU A CB  1 
ATOM   73   N  N   . VAL A 1 14  ? 123.848 191.536 164.600 1.00 32.98 ? 14   VAL A N   1 
ATOM   74   C  CA  . VAL A 1 14  ? 124.813 191.103 165.606 1.00 32.98 ? 14   VAL A CA  1 
ATOM   75   C  C   . VAL A 1 14  ? 125.720 190.019 165.038 1.00 32.98 ? 14   VAL A C   1 
ATOM   76   O  O   . VAL A 1 14  ? 126.930 190.014 165.282 1.00 32.98 ? 14   VAL A O   1 
ATOM   77   C  CB  . VAL A 1 14  ? 124.088 190.621 166.876 1.00 32.98 ? 14   VAL A CB  1 
ATOM   78   C  CG1 . VAL A 1 14  ? 125.025 189.786 167.736 1.00 32.98 ? 14   VAL A CG1 1 
ATOM   79   C  CG2 . VAL A 1 14  ? 123.558 191.807 167.667 1.00 32.98 ? 14   VAL A CG2 1 
ATOM   80   N  N   . LEU A 1 15  ? 125.149 189.074 164.291 1.00 30.89 ? 15   LEU A N   1 
ATOM   81   C  CA  . LEU A 1 15  ? 125.956 188.019 163.681 1.00 30.89 ? 15   LEU A CA  1 
ATOM   82   C  C   . LEU A 1 15  ? 127.029 188.610 162.775 1.00 30.89 ? 15   LEU A C   1 
ATOM   83   O  O   . LEU A 1 15  ? 128.207 188.241 162.857 1.00 30.89 ? 15   LEU A O   1 
ATOM   84   C  CB  . LEU A 1 15  ? 125.058 187.065 162.891 1.00 30.89 ? 15   LEU A CB  1 
ATOM   85   C  CG  . LEU A 1 15  ? 123.837 186.509 163.626 1.00 30.89 ? 15   LEU A CG  1 
ATOM   86   C  CD1 . LEU A 1 15  ? 123.107 185.479 162.796 1.00 30.89 ? 15   LEU A CD1 1 
ATOM   87   C  CD2 . LEU A 1 15  ? 124.243 185.916 164.968 1.00 30.89 ? 15   LEU A CD2 1 
ATOM   88   N  N   . GLN A 1 16  ? 126.633 189.534 161.899 1.00 26.22 ? 16   GLN A N   1 
ATOM   89   C  CA  . GLN A 1 16  ? 127.587 190.134 160.974 1.00 26.22 ? 16   GLN A CA  1 
ATOM   90   C  C   . GLN A 1 16  ? 128.653 190.929 161.716 1.00 26.22 ? 16   GLN A C   1 
ATOM   91   O  O   . GLN A 1 16  ? 129.843 190.843 161.385 1.00 26.22 ? 16   GLN A O   1 
ATOM   92   C  CB  . GLN A 1 16  ? 126.854 191.029 159.976 1.00 26.22 ? 16   GLN A CB  1 
ATOM   93   C  CG  . GLN A 1 16  ? 127.754 191.624 158.912 1.00 26.22 ? 16   GLN A CG  1 
ATOM   94   C  CD  . GLN A 1 16  ? 128.049 193.086 159.158 1.00 26.22 ? 16   GLN A CD  1 
ATOM   95   O  OE1 . GLN A 1 16  ? 127.230 193.809 159.725 1.00 26.22 ? 16   GLN A OE1 1 
ATOM   96   N  NE2 . GLN A 1 16  ? 129.227 193.531 158.739 1.00 26.22 ? 16   GLN A NE2 1 
ATOM   97   N  N   . ALA A 1 17  ? 128.249 191.713 162.718 1.00 23.72 ? 17   ALA A N   1 
ATOM   98   C  CA  . ALA A 1 17  ? 129.219 192.497 163.474 1.00 23.72 ? 17   ALA A CA  1 
ATOM   99   C  C   . ALA A 1 17  ? 130.200 191.591 164.201 1.00 23.72 ? 17   ALA A C   1 
ATOM   100  O  O   . ALA A 1 17  ? 131.400 191.877 164.254 1.00 23.72 ? 17   ALA A O   1 
ATOM   101  C  CB  . ALA A 1 17  ? 128.503 193.413 164.465 1.00 23.72 ? 17   ALA A CB  1 
ATOM   102  N  N   . GLY A 1 18  ? 129.704 190.497 164.779 1.00 22.50 ? 18   GLY A N   1 
ATOM   103  C  CA  . GLY A 1 18  ? 130.590 189.551 165.429 1.00 22.50 ? 18   GLY A CA  1 
ATOM   104  C  C   . GLY A 1 18  ? 131.569 188.923 164.460 1.00 22.50 ? 18   GLY A C   1 
ATOM   105  O  O   . GLY A 1 18  ? 132.754 188.792 164.762 1.00 22.50 ? 18   GLY A O   1 
ATOM   106  N  N   . PHE A 1 19  ? 131.091 188.528 163.281 1.00 19.60 ? 19   PHE A N   1 
ATOM   107  C  CA  . PHE A 1 19  ? 131.998 187.972 162.285 1.00 19.60 ? 19   PHE A CA  1 
ATOM   108  C  C   . PHE A 1 19  ? 133.083 188.977 161.925 1.00 19.60 ? 19   PHE A C   1 
ATOM   109  O  O   . PHE A 1 19  ? 134.272 188.640 161.885 1.00 19.60 ? 19   PHE A O   1 
ATOM   110  C  CB  . PHE A 1 19  ? 131.220 187.556 161.039 1.00 19.60 ? 19   PHE A CB  1 
ATOM   111  C  CG  . PHE A 1 19  ? 132.042 186.799 160.041 1.00 19.60 ? 19   PHE A CG  1 
ATOM   112  C  CD1 . PHE A 1 19  ? 132.183 185.428 160.139 1.00 19.60 ? 19   PHE A CD1 1 
ATOM   113  C  CD2 . PHE A 1 19  ? 132.676 187.461 159.004 1.00 19.60 ? 19   PHE A CD2 1 
ATOM   114  C  CE1 . PHE A 1 19  ? 132.939 184.730 159.222 1.00 19.60 ? 19   PHE A CE1 1 
ATOM   115  C  CE2 . PHE A 1 19  ? 133.435 186.768 158.083 1.00 19.60 ? 19   PHE A CE2 1 
ATOM   116  C  CZ  . PHE A 1 19  ? 133.566 185.400 158.193 1.00 19.60 ? 19   PHE A CZ  1 
ATOM   117  N  N   . PHE A 1 20  ? 132.691 190.225 161.672 1.00 16.65 ? 20   PHE A N   1 
ATOM   118  C  CA  . PHE A 1 20  ? 133.667 191.235 161.277 1.00 16.65 ? 20   PHE A CA  1 
ATOM   119  C  C   . PHE A 1 20  ? 134.677 191.488 162.389 1.00 16.65 ? 20   PHE A C   1 
ATOM   120  O  O   . PHE A 1 20  ? 135.887 191.530 162.140 1.00 16.65 ? 20   PHE A O   1 
ATOM   121  C  CB  . PHE A 1 20  ? 132.947 192.528 160.892 1.00 16.65 ? 20   PHE A CB  1 
ATOM   122  C  CG  . PHE A 1 20  ? 133.871 193.672 160.576 1.00 16.65 ? 20   PHE A CG  1 
ATOM   123  C  CD1 . PHE A 1 20  ? 134.323 194.519 161.576 1.00 16.65 ? 20   PHE A CD1 1 
ATOM   124  C  CD2 . PHE A 1 20  ? 134.276 193.908 159.272 1.00 16.65 ? 20   PHE A CD2 1 
ATOM   125  C  CE1 . PHE A 1 20  ? 135.168 195.571 161.283 1.00 16.65 ? 20   PHE A CE1 1 
ATOM   126  C  CE2 . PHE A 1 20  ? 135.120 194.961 158.973 1.00 16.65 ? 20   PHE A CE2 1 
ATOM   127  C  CZ  . PHE A 1 20  ? 135.567 195.792 159.980 1.00 16.65 ? 20   PHE A CZ  1 
ATOM   128  N  N   . LEU A 1 21  ? 134.205 191.647 163.626 1.00 16.01 ? 21   LEU A N   1 
ATOM   129  C  CA  . LEU A 1 21  ? 135.122 191.912 164.728 1.00 16.01 ? 21   LEU A CA  1 
ATOM   130  C  C   . LEU A 1 21  ? 136.047 190.730 164.981 1.00 16.01 ? 21   LEU A C   1 
ATOM   131  O  O   . LEU A 1 21  ? 137.237 190.921 165.241 1.00 16.01 ? 21   LEU A O   1 
ATOM   132  C  CB  . LEU A 1 21  ? 134.346 192.263 165.997 1.00 16.01 ? 21   LEU A CB  1 
ATOM   133  C  CG  . LEU A 1 21  ? 133.982 193.738 166.205 1.00 16.01 ? 21   LEU A CG  1 
ATOM   134  C  CD1 . LEU A 1 21  ? 135.237 194.591 166.364 1.00 16.01 ? 21   LEU A CD1 1 
ATOM   135  C  CD2 . LEU A 1 21  ? 133.103 194.278 165.083 1.00 16.01 ? 21   LEU A CD2 1 
ATOM   136  N  N   . LEU A 1 22  ? 135.529 189.501 164.914 1.00 14.07 ? 22   LEU A N   1 
ATOM   137  C  CA  . LEU A 1 22  ? 136.380 188.338 165.141 1.00 14.07 ? 22   LEU A CA  1 
ATOM   138  C  C   . LEU A 1 22  ? 137.411 188.171 164.033 1.00 14.07 ? 22   LEU A C   1 
ATOM   139  O  O   . LEU A 1 22  ? 138.554 187.787 164.301 1.00 14.07 ? 22   LEU A O   1 
ATOM   140  C  CB  . LEU A 1 22  ? 135.535 187.070 165.287 1.00 14.07 ? 22   LEU A CB  1 
ATOM   141  C  CG  . LEU A 1 22  ? 134.846 186.794 166.633 1.00 14.07 ? 22   LEU A CG  1 
ATOM   142  C  CD1 . LEU A 1 22  ? 135.906 186.513 167.693 1.00 14.07 ? 22   LEU A CD1 1 
ATOM   143  C  CD2 . LEU A 1 22  ? 133.913 187.903 167.112 1.00 14.07 ? 22   LEU A CD2 1 
ATOM   144  N  N   . THR A 1 23  ? 137.038 188.449 162.782 1.00 12.70 ? 23   THR A N   1 
ATOM   145  C  CA  . THR A 1 23  ? 138.006 188.292 161.701 1.00 12.70 ? 23   THR A CA  1 
ATOM   146  C  C   . THR A 1 23  ? 139.031 189.420 161.713 1.00 12.70 ? 23   THR A C   1 
ATOM   147  O  O   . THR A 1 23  ? 140.156 189.248 161.231 1.00 12.70 ? 23   THR A O   1 
ATOM   148  C  CB  . THR A 1 23  ? 137.296 188.215 160.347 1.00 12.70 ? 23   THR A CB  1 
ATOM   149  O  OG1 . THR A 1 23  ? 138.178 187.639 159.377 1.00 12.70 ? 23   THR A OG1 1 
ATOM   150  C  CG2 . THR A 1 23  ? 136.856 189.591 159.867 1.00 12.70 ? 23   THR A CG2 1 
ATOM   151  N  N   . ARG A 1 24  ? 138.660 190.586 162.249 1.00 13.31 ? 24   ARG A N   1 
ATOM   152  C  CA  . ARG A 1 24  ? 139.628 191.671 162.374 1.00 13.31 ? 24   ARG A CA  1 
ATOM   153  C  C   . ARG A 1 24  ? 140.548 191.469 163.572 1.00 13.31 ? 24   ARG A C   1 
ATOM   154  O  O   . ARG A 1 24  ? 141.725 191.841 163.524 1.00 13.31 ? 24   ARG A O   1 
ATOM   155  C  CB  . ARG A 1 24  ? 138.906 193.013 162.479 1.00 13.31 ? 24   ARG A CB  1 
ATOM   156  C  CG  . ARG A 1 24  ? 138.159 193.422 161.220 1.00 13.31 ? 24   ARG A CG  1 
ATOM   157  C  CD  . ARG A 1 24  ? 139.123 193.776 160.103 1.00 13.31 ? 24   ARG A CD  1 
ATOM   158  N  NE  . ARG A 1 24  ? 138.437 194.273 158.917 1.00 13.31 ? 24   ARG A NE  1 
ATOM   159  C  CZ  . ARG A 1 24  ? 139.040 194.572 157.774 1.00 13.31 ? 24   ARG A CZ  1 
ATOM   160  N  NH1 . ARG A 1 24  ? 140.348 194.437 157.626 1.00 13.31 ? 24   ARG A NH1 1 
ATOM   161  N  NH2 . ARG A 1 24  ? 138.313 195.019 156.754 1.00 13.31 ? 24   ARG A NH2 1 
ATOM   162  N  N   . ILE A 1 25  ? 140.032 190.887 164.661 1.00 8.33  ? 25   ILE A N   1 
ATOM   163  C  CA  . ILE A 1 25  ? 140.792 190.801 165.906 1.00 8.33  ? 25   ILE A CA  1 
ATOM   164  C  C   . ILE A 1 25  ? 141.516 189.478 166.075 1.00 8.33  ? 25   ILE A C   1 
ATOM   165  O  O   . ILE A 1 25  ? 142.404 189.378 166.926 1.00 8.33  ? 25   ILE A O   1 
ATOM   166  C  CB  . ILE A 1 25  ? 139.870 191.009 167.122 1.00 8.33  ? 25   ILE A CB  1 
ATOM   167  C  CG1 . ILE A 1 25  ? 140.679 191.240 168.404 1.00 8.33  ? 25   ILE A CG1 1 
ATOM   168  C  CG2 . ILE A 1 25  ? 138.987 189.797 167.316 1.00 8.33  ? 25   ILE A CG2 1 
ATOM   169  C  CD1 . ILE A 1 25  ? 141.483 192.525 168.417 1.00 8.33  ? 25   ILE A CD1 1 
ATOM   170  N  N   . LEU A 1 26  ? 141.168 188.458 165.298 1.00 5.99  ? 26   LEU A N   1 
ATOM   171  C  CA  . LEU A 1 26  ? 141.863 187.182 165.362 1.00 5.99  ? 26   LEU A CA  1 
ATOM   172  C  C   . LEU A 1 26  ? 143.119 187.154 164.507 1.00 5.99  ? 26   LEU A C   1 
ATOM   173  O  O   . LEU A 1 26  ? 143.939 186.246 164.670 1.00 5.99  ? 26   LEU A O   1 
ATOM   174  C  CB  . LEU A 1 26  ? 140.923 186.049 164.936 1.00 5.99  ? 26   LEU A CB  1 
ATOM   175  C  CG  . LEU A 1 26  ? 141.469 184.630 165.077 1.00 5.99  ? 26   LEU A CG  1 
ATOM   176  C  CD1 . LEU A 1 26  ? 140.379 183.700 165.571 1.00 5.99  ? 26   LEU A CD1 1 
ATOM   177  C  CD2 . LEU A 1 26  ? 142.016 184.133 163.746 1.00 5.99  ? 26   LEU A CD2 1 
ATOM   178  N  N   . THR A 1 27  ? 143.292 188.123 163.611 1.00 4.05  ? 27   THR A N   1 
ATOM   179  C  CA  . THR A 1 27  ? 144.499 188.190 162.802 1.00 4.05  ? 27   THR A CA  1 
ATOM   180  C  C   . THR A 1 27  ? 145.624 188.947 163.493 1.00 4.05  ? 27   THR A C   1 
ATOM   181  O  O   . THR A 1 27  ? 146.745 188.963 162.975 1.00 4.05  ? 27   THR A O   1 
ATOM   182  C  CB  . THR A 1 27  ? 144.200 188.857 161.460 1.00 4.05  ? 27   THR A CB  1 
ATOM   183  O  OG1 . THR A 1 27  ? 145.333 188.720 160.595 1.00 4.05  ? 27   THR A OG1 1 
ATOM   184  C  CG2 . THR A 1 27  ? 143.902 190.336 161.656 1.00 4.05  ? 27   THR A CG2 1 
ATOM   185  N  N   . ILE A 1 28  ? 145.358 189.576 164.633 1.00 3.02  ? 28   ILE A N   1 
ATOM   186  C  CA  . ILE A 1 28  ? 146.374 190.373 165.316 1.00 3.02  ? 28   ILE A CA  1 
ATOM   187  C  C   . ILE A 1 28  ? 147.601 189.515 165.617 1.00 3.02  ? 28   ILE A C   1 
ATOM   188  O  O   . ILE A 1 28  ? 148.722 190.042 165.561 1.00 3.02  ? 28   ILE A O   1 
ATOM   189  C  CB  . ILE A 1 28  ? 145.820 191.058 166.580 1.00 3.02  ? 28   ILE A CB  1 
ATOM   190  C  CG1 . ILE A 1 28  ? 146.946 191.761 167.340 1.00 3.02  ? 28   ILE A CG1 1 
ATOM   191  C  CG2 . ILE A 1 28  ? 145.115 190.102 167.509 1.00 3.02  ? 28   ILE A CG2 1 
ATOM   192  C  CD1 . ILE A 1 28  ? 146.452 192.661 168.451 1.00 3.02  ? 28   ILE A CD1 1 
ATOM   193  N  N   . PRO A 1 29  ? 147.479 188.220 165.944 1.00 2.26  ? 29   PRO A N   1 
ATOM   194  C  CA  . PRO A 1 29  ? 148.708 187.415 166.021 1.00 2.26  ? 29   PRO A CA  1 
ATOM   195  C  C   . PRO A 1 29  ? 149.522 187.471 164.745 1.00 2.26  ? 29   PRO A C   1 
ATOM   196  O  O   . PRO A 1 29  ? 150.748 187.597 164.806 1.00 2.26  ? 29   PRO A O   1 
ATOM   197  C  CB  . PRO A 1 29  ? 148.202 185.992 166.294 1.00 2.26  ? 29   PRO A CB  1 
ATOM   198  C  CG  . PRO A 1 29  ? 146.764 186.073 166.511 1.00 2.26  ? 29   PRO A CG  1 
ATOM   199  C  CD  . PRO A 1 29  ? 146.319 187.484 166.475 1.00 2.26  ? 29   PRO A CD  1 
ATOM   200  N  N   . GLN A 1 30  ? 148.871 187.399 163.583 1.00 2.18  ? 30   GLN A N   1 
ATOM   201  C  CA  . GLN A 1 30  ? 149.604 187.455 162.322 1.00 2.18  ? 30   GLN A CA  1 
ATOM   202  C  C   . GLN A 1 30  ? 150.263 188.811 162.127 1.00 2.18  ? 30   GLN A C   1 
ATOM   203  O  O   . GLN A 1 30  ? 151.417 188.889 161.695 1.00 2.18  ? 30   GLN A O   1 
ATOM   204  C  CB  . GLN A 1 30  ? 148.668 187.150 161.156 1.00 2.18  ? 30   GLN A CB  1 
ATOM   205  C  CG  . GLN A 1 30  ? 149.382 186.941 159.836 1.00 2.18  ? 30   GLN A CG  1 
ATOM   206  C  CD  . GLN A 1 30  ? 148.493 186.300 158.790 1.00 2.18  ? 30   GLN A CD  1 
ATOM   207  O  OE1 . GLN A 1 30  ? 148.137 185.127 158.898 1.00 2.18  ? 30   GLN A OE1 1 
ATOM   208  N  NE2 . GLN A 1 30  ? 148.131 187.068 157.770 1.00 2.18  ? 30   GLN A NE2 1 
ATOM   209  N  N   . SER A 1 31  ? 149.545 189.892 162.434 1.00 1.91  ? 31   SER A N   1 
ATOM   210  C  CA  . SER A 1 31  ? 150.121 191.220 162.265 1.00 1.91  ? 31   SER A CA  1 
ATOM   211  C  C   . SER A 1 31  ? 151.336 191.405 163.162 1.00 1.91  ? 31   SER A C   1 
ATOM   212  O  O   . SER A 1 31  ? 152.361 191.940 162.728 1.00 1.91  ? 31   SER A O   1 
ATOM   213  C  CB  . SER A 1 31  ? 149.074 192.290 162.559 1.00 1.91  ? 31   SER A CB  1 
ATOM   214  O  OG  . SER A 1 31  ? 149.077 192.629 163.933 1.00 1.91  ? 31   SER A OG  1 
ATOM   215  N  N   . LEU A 1 32  ? 151.249 190.953 164.413 1.00 1.76  ? 32   LEU A N   1 
ATOM   216  C  CA  . LEU A 1 32  ? 152.375 191.115 165.328 1.00 1.76  ? 32   LEU A CA  1 
ATOM   217  C  C   . LEU A 1 32  ? 153.539 190.207 164.948 1.00 1.76  ? 32   LEU A C   1 
ATOM   218  O  O   . LEU A 1 32  ? 154.705 190.603 165.063 1.00 1.76  ? 32   LEU A O   1 
ATOM   219  C  CB  . LEU A 1 32  ? 151.919 190.845 166.758 1.00 1.76  ? 32   LEU A CB  1 
ATOM   220  C  CG  . LEU A 1 32  ? 151.384 192.092 167.459 1.00 1.76  ? 32   LEU A CG  1 
ATOM   221  C  CD1 . LEU A 1 32  ? 150.590 191.720 168.680 1.00 1.76  ? 32   LEU A CD1 1 
ATOM   222  C  CD2 . LEU A 1 32  ? 152.520 193.023 167.834 1.00 1.76  ? 32   LEU A CD2 1 
ATOM   223  N  N   . ASP A 1 33  ? 153.248 188.988 164.491 1.00 1.49  ? 33   ASP A N   1 
ATOM   224  C  CA  . ASP A 1 33  ? 154.305 188.105 164.018 1.00 1.49  ? 33   ASP A CA  1 
ATOM   225  C  C   . ASP A 1 33  ? 155.037 188.719 162.835 1.00 1.49  ? 33   ASP A C   1 
ATOM   226  O  O   . ASP A 1 33  ? 156.273 188.712 162.784 1.00 1.49  ? 33   ASP A O   1 
ATOM   227  C  CB  . ASP A 1 33  ? 153.710 186.751 163.637 1.00 1.49  ? 33   ASP A CB  1 
ATOM   228  C  CG  . ASP A 1 33  ? 154.704 185.851 162.947 1.00 1.49  ? 33   ASP A CG  1 
ATOM   229  O  OD1 . ASP A 1 33  ? 155.909 185.962 163.245 1.00 1.49  ? 33   ASP A OD1 1 
ATOM   230  O  OD2 . ASP A 1 33  ? 154.284 185.026 162.111 1.00 1.49  ? 33   ASP A OD2 1 
ATOM   231  N  N   . SER A 1 34  ? 154.288 189.270 161.880 1.00 1.27  ? 34   SER A N   1 
ATOM   232  C  CA  . SER A 1 34  ? 154.914 189.927 160.741 1.00 1.27  ? 34   SER A CA  1 
ATOM   233  C  C   . SER A 1 34  ? 155.704 191.149 161.184 1.00 1.27  ? 34   SER A C   1 
ATOM   234  O  O   . SER A 1 34  ? 156.780 191.426 160.647 1.00 1.27  ? 34   SER A O   1 
ATOM   235  C  CB  . SER A 1 34  ? 153.855 190.319 159.716 1.00 1.27  ? 34   SER A CB  1 
ATOM   236  O  OG  . SER A 1 34  ? 153.006 191.325 160.234 1.00 1.27  ? 34   SER A OG  1 
ATOM   237  N  N   . TRP A 1 35  ? 155.190 191.896 162.163 1.00 0.94  ? 35   TRP A N   1 
ATOM   238  C  CA  . TRP A 1 35  ? 155.904 193.080 162.626 1.00 0.94  ? 35   TRP A CA  1 
ATOM   239  C  C   . TRP A 1 35  ? 157.242 192.703 163.246 1.00 0.94  ? 35   TRP A C   1 
ATOM   240  O  O   . TRP A 1 35  ? 158.268 193.336 162.974 1.00 0.94  ? 35   TRP A O   1 
ATOM   241  C  CB  . TRP A 1 35  ? 155.052 193.854 163.628 1.00 0.94  ? 35   TRP A CB  1 
ATOM   242  C  CG  . TRP A 1 35  ? 155.842 194.832 164.435 1.00 0.94  ? 35   TRP A CG  1 
ATOM   243  C  CD1 . TRP A 1 35  ? 156.308 196.043 164.022 1.00 0.94  ? 35   TRP A CD1 1 
ATOM   244  C  CD2 . TRP A 1 35  ? 156.253 194.689 165.799 1.00 0.94  ? 35   TRP A CD2 1 
ATOM   245  N  NE1 . TRP A 1 35  ? 156.987 196.661 165.039 1.00 0.94  ? 35   TRP A NE1 1 
ATOM   246  C  CE2 . TRP A 1 35  ? 156.966 195.850 166.142 1.00 0.94  ? 35   TRP A CE2 1 
ATOM   247  C  CE3 . TRP A 1 35  ? 156.088 193.691 166.761 1.00 0.94  ? 35   TRP A CE3 1 
ATOM   248  C  CZ2 . TRP A 1 35  ? 157.513 196.041 167.405 1.00 0.94  ? 35   TRP A CZ2 1 
ATOM   249  C  CZ3 . TRP A 1 35  ? 156.632 193.884 168.014 1.00 0.94  ? 35   TRP A CZ3 1 
ATOM   250  C  CH2 . TRP A 1 35  ? 157.336 195.048 168.324 1.00 0.94  ? 35   TRP A CH2 1 
ATOM   251  N  N   . TRP A 1 36  ? 157.255 191.672 164.088 1.00 0.98  ? 36   TRP A N   1 
ATOM   252  C  CA  . TRP A 1 36  ? 158.518 191.255 164.686 1.00 0.98  ? 36   TRP A CA  1 
ATOM   253  C  C   . TRP A 1 36  ? 159.474 190.715 163.632 1.00 0.98  ? 36   TRP A C   1 
ATOM   254  O  O   . TRP A 1 36  ? 160.671 191.030 163.650 1.00 0.98  ? 36   TRP A O   1 
ATOM   255  C  CB  . TRP A 1 36  ? 158.271 190.219 165.775 1.00 0.98  ? 36   TRP A CB  1 
ATOM   256  C  CG  . TRP A 1 36  ? 159.473 189.964 166.606 1.00 0.98  ? 36   TRP A CG  1 
ATOM   257  C  CD1 . TRP A 1 36  ? 160.480 189.089 166.345 1.00 0.98  ? 36   TRP A CD1 1 
ATOM   258  C  CD2 . TRP A 1 36  ? 159.819 190.623 167.823 1.00 0.98  ? 36   TRP A CD2 1 
ATOM   259  N  NE1 . TRP A 1 36  ? 161.422 189.143 167.339 1.00 0.98  ? 36   TRP A NE1 1 
ATOM   260  C  CE2 . TRP A 1 36  ? 161.038 190.083 168.258 1.00 0.98  ? 36   TRP A CE2 1 
ATOM   261  C  CE3 . TRP A 1 36  ? 159.209 191.613 168.594 1.00 0.98  ? 36   TRP A CE3 1 
ATOM   262  C  CZ2 . TRP A 1 36  ? 161.656 190.496 169.425 1.00 0.98  ? 36   TRP A CZ2 1 
ATOM   263  C  CZ3 . TRP A 1 36  ? 159.826 192.021 169.750 1.00 0.98  ? 36   TRP A CZ3 1 
ATOM   264  C  CH2 . TRP A 1 36  ? 161.037 191.466 170.155 1.00 0.98  ? 36   TRP A CH2 1 
ATOM   265  N  N   . THR A 1 37  ? 158.972 189.907 162.698 1.00 1.03  ? 37   THR A N   1 
ATOM   266  C  CA  . THR A 1 37  ? 159.838 189.418 161.633 1.00 1.03  ? 37   THR A CA  1 
ATOM   267  C  C   . THR A 1 37  ? 160.391 190.573 160.809 1.00 1.03  ? 37   THR A C   1 
ATOM   268  O  O   . THR A 1 37  ? 161.491 190.477 160.255 1.00 1.03  ? 37   THR A O   1 
ATOM   269  C  CB  . THR A 1 37  ? 159.080 188.434 160.746 1.00 1.03  ? 37   THR A CB  1 
ATOM   270  O  OG1 . THR A 1 37  ? 158.792 187.246 161.491 1.00 1.03  ? 37   THR A OG1 1 
ATOM   271  C  CG2 . THR A 1 37  ? 159.901 188.069 159.526 1.00 1.03  ? 37   THR A CG2 1 
ATOM   272  N  N   . SER A 1 38  ? 159.640 191.670 160.705 1.00 1.01  ? 38   SER A N   1 
ATOM   273  C  CA  . SER A 1 38  ? 160.172 192.861 160.054 1.00 1.01  ? 38   SER A CA  1 
ATOM   274  C  C   . SER A 1 38  ? 161.278 193.484 160.890 1.00 1.01  ? 38   SER A C   1 
ATOM   275  O  O   . SER A 1 38  ? 162.308 193.907 160.356 1.00 1.01  ? 38   SER A O   1 
ATOM   276  C  CB  . SER A 1 38  ? 159.059 193.876 159.809 1.00 1.01  ? 38   SER A CB  1 
ATOM   277  O  OG  . SER A 1 38  ? 158.255 194.036 160.960 1.00 1.01  ? 38   SER A OG  1 
ATOM   278  N  N   . LEU A 1 39  ? 161.081 193.552 162.207 1.00 0.79  ? 39   LEU A N   1 
ATOM   279  C  CA  . LEU A 1 39  ? 162.150 194.045 163.070 1.00 0.79  ? 39   LEU A CA  1 
ATOM   280  C  C   . LEU A 1 39  ? 163.422 193.238 162.877 1.00 0.79  ? 39   LEU A C   1 
ATOM   281  O  O   . LEU A 1 39  ? 164.524 193.789 162.963 1.00 0.79  ? 39   LEU A O   1 
ATOM   282  C  CB  . LEU A 1 39  ? 161.737 193.997 164.541 1.00 0.79  ? 39   LEU A CB  1 
ATOM   283  C  CG  . LEU A 1 39  ? 160.731 195.025 165.052 1.00 0.79  ? 39   LEU A CG  1 
ATOM   284  C  CD1 . LEU A 1 39  ? 160.718 195.004 166.567 1.00 0.79  ? 39   LEU A CD1 1 
ATOM   285  C  CD2 . LEU A 1 39  ? 161.038 196.413 164.539 1.00 0.79  ? 39   LEU A CD2 1 
ATOM   286  N  N   . ASN A 1 40  ? 163.300 191.967 162.547 1.00 0.98  ? 40   ASN A N   1 
ATOM   287  C  CA  . ASN A 1 40  ? 164.459 191.154 162.278 1.00 0.98  ? 40   ASN A CA  1 
ATOM   288  C  C   . ASN A 1 40  ? 165.258 191.582 161.074 1.00 0.98  ? 40   ASN A C   1 
ATOM   289  O  O   . ASN A 1 40  ? 166.449 191.427 161.085 1.00 0.98  ? 40   ASN A O   1 
ATOM   290  C  CB  . ASN A 1 40  ? 164.038 189.727 162.069 1.00 0.98  ? 40   ASN A CB  1 
ATOM   291  C  CG  . ASN A 1 40  ? 164.328 188.865 163.248 1.00 0.98  ? 40   ASN A CG  1 
ATOM   292  O  OD1 . ASN A 1 40  ? 165.404 188.322 163.354 1.00 0.98  ? 40   ASN A OD1 1 
ATOM   293  N  ND2 . ASN A 1 40  ? 163.363 188.711 164.127 1.00 0.98  ? 40   ASN A ND2 1 
ATOM   294  N  N   . PHE A 1 41  ? 164.652 192.115 160.028 1.00 1.42  ? 41   PHE A N   1 
ATOM   295  C  CA  . PHE A 1 41  ? 165.468 192.482 158.878 1.00 1.42  ? 41   PHE A CA  1 
ATOM   296  C  C   . PHE A 1 41  ? 165.227 193.886 158.411 1.00 1.42  ? 41   PHE A C   1 
ATOM   297  O  O   . PHE A 1 41  ? 164.677 194.098 157.344 1.00 1.42  ? 41   PHE A O   1 
ATOM   298  C  CB  . PHE A 1 41  ? 165.229 191.561 157.667 1.00 1.42  ? 41   PHE A CB  1 
ATOM   299  C  CG  . PHE A 1 41  ? 164.766 190.203 158.006 1.00 1.42  ? 41   PHE A CG  1 
ATOM   300  C  CD1 . PHE A 1 41  ? 165.626 189.294 158.572 1.00 1.42  ? 41   PHE A CD1 1 
ATOM   301  C  CD2 . PHE A 1 41  ? 163.490 189.821 157.712 1.00 1.42  ? 41   PHE A CD2 1 
ATOM   302  C  CE1 . PHE A 1 41  ? 165.208 188.024 158.863 1.00 1.42  ? 41   PHE A CE1 1 
ATOM   303  C  CE2 . PHE A 1 41  ? 163.061 188.558 158.009 1.00 1.42  ? 41   PHE A CE2 1 
ATOM   304  C  CZ  . PHE A 1 41  ? 163.916 187.656 158.598 1.00 1.42  ? 41   PHE A CZ  1 
ATOM   305  N  N   . LEU A 1 42  ? 165.596 194.852 159.228 1.00 1.46  ? 42   LEU A N   1 
ATOM   306  C  CA  . LEU A 1 42  ? 165.486 196.265 158.876 1.00 1.46  ? 42   LEU A CA  1 
ATOM   307  C  C   . LEU A 1 42  ? 164.094 196.677 158.368 1.00 1.46  ? 42   LEU A C   1 
ATOM   308  O  O   . LEU A 1 42  ? 163.991 197.470 157.449 1.00 1.46  ? 42   LEU A O   1 
ATOM   309  C  CB  . LEU A 1 42  ? 166.560 196.644 157.835 1.00 1.46  ? 42   LEU A CB  1 
ATOM   310  C  CG  . LEU A 1 42  ? 168.040 196.441 158.142 1.00 1.46  ? 42   LEU A CG  1 
ATOM   311  C  CD1 . LEU A 1 42  ? 168.336 195.146 158.873 1.00 1.46  ? 42   LEU A CD1 1 
ATOM   312  C  CD2 . LEU A 1 42  ? 168.809 196.503 156.837 1.00 1.46  ? 42   LEU A CD2 1 
ATOM   313  N  N   . GLY A 1 43  ? 163.026 196.063 158.849 1.00 1.33  ? 43   GLY A N   1 
ATOM   314  C  CA  . GLY A 1 43  ? 161.724 196.444 158.335 1.00 1.33  ? 43   GLY A CA  1 
ATOM   315  C  C   . GLY A 1 43  ? 161.272 195.717 157.064 1.00 1.33  ? 43   GLY A C   1 
ATOM   316  O  O   . GLY A 1 43  ? 160.560 196.309 156.253 1.00 1.33  ? 43   GLY A O   1 
ATOM   317  N  N   . GLY A 1 44  ? 161.670 194.456 156.873 1.00 1.22  ? 44   GLY A N   1 
ATOM   318  C  CA  . GLY A 1 44  ? 161.300 193.711 155.669 1.00 1.22  ? 44   GLY A CA  1 
ATOM   319  C  C   . GLY A 1 44  ? 160.819 192.279 155.889 1.00 1.22  ? 44   GLY A C   1 
ATOM   320  O  O   . GLY A 1 44  ? 161.036 191.728 156.952 1.00 1.22  ? 44   GLY A O   1 
ATOM   321  N  N   . THR A 1 45  ? 160.033 191.742 154.954 1.00 1.81  ? 45   THR A N   1 
ATOM   322  C  CA  . THR A 1 45  ? 159.530 190.353 155.020 1.00 1.81  ? 45   THR A CA  1 
ATOM   323  C  C   . THR A 1 45  ? 160.457 189.123 154.771 1.00 1.81  ? 45   THR A C   1 
ATOM   324  O  O   . THR A 1 45  ? 160.408 188.146 155.518 1.00 1.81  ? 45   THR A O   1 
ATOM   325  C  CB  . THR A 1 45  ? 158.336 190.190 154.057 1.00 1.81  ? 45   THR A CB  1 
ATOM   326  O  OG1 . THR A 1 45  ? 157.355 191.198 154.330 1.00 1.81  ? 45   THR A OG1 1 
ATOM   327  C  CG2 . THR A 1 45  ? 157.705 188.814 154.210 1.00 1.81  ? 45   THR A CG2 1 
ATOM   328  N  N   . THR A 1 46  ? 161.285 189.158 153.719 1.00 2.06  ? 46   THR A N   1 
ATOM   329  C  CA  . THR A 1 46  ? 162.218 188.048 153.342 1.00 2.06  ? 46   THR A CA  1 
ATOM   330  C  C   . THR A 1 46  ? 161.453 186.742 152.885 1.00 2.06  ? 46   THR A C   1 
ATOM   331  O  O   . THR A 1 46  ? 160.284 186.857 152.507 1.00 2.06  ? 46   THR A O   1 
ATOM   332  C  CB  . THR A 1 46  ? 163.378 187.855 154.374 1.00 2.06  ? 46   THR A CB  1 
ATOM   333  O  OG1 . THR A 1 46  ? 162.892 187.160 155.529 1.00 2.06  ? 46   THR A OG1 1 
ATOM   334  C  CG2 . THR A 1 46  ? 163.957 189.198 154.788 1.00 2.06  ? 46   THR A CG2 1 
ATOM   335  N  N   . VAL A 1 47  ? 162.043 185.526 152.841 1.00 2.84  ? 47   VAL A N   1 
ATOM   336  C  CA  . VAL A 1 47  ? 161.284 184.398 152.320 1.00 2.84  ? 47   VAL A CA  1 
ATOM   337  C  C   . VAL A 1 47  ? 161.411 183.248 153.303 1.00 2.84  ? 47   VAL A C   1 
ATOM   338  O  O   . VAL A 1 47  ? 162.324 183.216 154.131 1.00 2.84  ? 47   VAL A O   1 
ATOM   339  C  CB  . VAL A 1 47  ? 161.777 183.976 150.916 1.00 2.84  ? 47   VAL A CB  1 
ATOM   340  C  CG1 . VAL A 1 47  ? 161.589 185.108 149.923 1.00 2.84  ? 47   VAL A CG1 1 
ATOM   341  C  CG2 . VAL A 1 47  ? 163.237 183.555 150.970 1.00 2.84  ? 47   VAL A CG2 1 
ATOM   342  N  N   . CYS A 1 48  ? 160.490 182.295 153.205 1.00 2.92  ? 48   CYS A N   1 
ATOM   343  C  CA  . CYS A 1 48  ? 160.555 181.113 154.047 1.00 2.92  ? 48   CYS A CA  1 
ATOM   344  C  C   . CYS A 1 48  ? 161.408 180.036 153.385 1.00 2.92  ? 48   CYS A C   1 
ATOM   345  O  O   . CYS A 1 48  ? 161.914 180.197 152.271 1.00 2.92  ? 48   CYS A O   1 
ATOM   346  C  CB  . CYS A 1 48  ? 159.156 180.574 154.328 1.00 2.92  ? 48   CYS A CB  1 
ATOM   347  S  SG  . CYS A 1 48  ? 159.147 178.917 155.040 1.00 2.92  ? 48   CYS A SG  1 
ATOM   348  N  N   . LEU A 1 49  ? 161.568 178.920 154.092 1.00 2.45  ? 49   LEU A N   1 
ATOM   349  C  CA  . LEU A 1 49  ? 162.325 177.779 153.577 1.00 2.45  ? 49   LEU A CA  1 
ATOM   350  C  C   . LEU A 1 49  ? 161.353 176.770 152.962 1.00 2.45  ? 49   LEU A C   1 
ATOM   351  O  O   . LEU A 1 49  ? 161.193 175.636 153.418 1.00 2.45  ? 49   LEU A O   1 
ATOM   352  C  CB  . LEU A 1 49  ? 163.163 177.155 154.685 1.00 2.45  ? 49   LEU A CB  1 
ATOM   353  C  CG  . LEU A 1 49  ? 164.196 178.073 155.345 1.00 2.45  ? 49   LEU A CG  1 
ATOM   354  C  CD1 . LEU A 1 49  ? 164.965 177.323 156.420 1.00 2.45  ? 49   LEU A CD1 1 
ATOM   355  C  CD2 . LEU A 1 49  ? 165.147 178.662 154.317 1.00 2.45  ? 49   LEU A CD2 1 
ATOM   356  N  N   . GLY A 1 50  ? 160.694 177.217 151.898 1.00 2.84  ? 50   GLY A N   1 
ATOM   357  C  CA  . GLY A 1 50  ? 159.722 176.398 151.202 1.00 2.84  ? 50   GLY A CA  1 
ATOM   358  C  C   . GLY A 1 50  ? 158.696 177.230 150.459 1.00 2.84  ? 50   GLY A C   1 
ATOM   359  O  O   . GLY A 1 50  ? 158.985 178.344 150.020 1.00 2.84  ? 50   GLY A O   1 
ATOM   360  N  N   . THR A 1 57  ? 156.195 177.939 144.314 1.00 11.65 ? 57   THR A N   1 
ATOM   361  C  CA  . THR A 1 57  ? 156.325 178.335 145.711 1.00 11.65 ? 57   THR A CA  1 
ATOM   362  C  C   . THR A 1 57  ? 155.786 179.744 145.928 1.00 11.65 ? 57   THR A C   1 
ATOM   363  O  O   . THR A 1 57  ? 155.059 179.999 146.885 1.00 11.65 ? 57   THR A O   1 
ATOM   364  C  CB  . THR A 1 57  ? 157.790 178.280 146.178 1.00 11.65 ? 57   THR A CB  1 
ATOM   365  N  N   . SER A 1 58  ? 156.150 180.658 145.030 1.00 11.73 ? 58   SER A N   1 
ATOM   366  C  CA  . SER A 1 58  ? 155.742 182.059 145.064 1.00 11.73 ? 58   SER A CA  1 
ATOM   367  C  C   . SER A 1 58  ? 156.453 182.856 146.150 1.00 11.73 ? 58   SER A C   1 
ATOM   368  O  O   . SER A 1 58  ? 156.142 184.039 146.342 1.00 11.73 ? 58   SER A O   1 
ATOM   369  C  CB  . SER A 1 58  ? 154.226 182.199 145.250 1.00 11.73 ? 58   SER A CB  1 
ATOM   370  O  OG  . SER A 1 58  ? 153.860 182.041 146.610 1.00 11.73 ? 58   SER A OG  1 
ATOM   371  N  N   . ASN A 1 59  ? 157.398 182.246 146.869 1.00 8.58  ? 59   ASN A N   1 
ATOM   372  C  CA  . ASN A 1 59  ? 158.195 182.947 147.875 1.00 8.58  ? 59   ASN A CA  1 
ATOM   373  C  C   . ASN A 1 59  ? 157.302 183.655 148.892 1.00 8.58  ? 59   ASN A C   1 
ATOM   374  O  O   . ASN A 1 59  ? 157.408 184.863 149.115 1.00 8.58  ? 59   ASN A O   1 
ATOM   375  C  CB  . ASN A 1 59  ? 159.157 183.934 147.211 1.00 8.58  ? 59   ASN A CB  1 
ATOM   376  N  N   . HIS A 1 60  ? 156.413 182.888 149.514 1.00 4.40  ? 60   HIS A N   1 
ATOM   377  C  CA  . HIS A 1 60  ? 155.527 183.440 150.527 1.00 4.40  ? 60   HIS A CA  1 
ATOM   378  C  C   . HIS A 1 60  ? 156.322 183.882 151.751 1.00 4.40  ? 60   HIS A C   1 
ATOM   379  O  O   . HIS A 1 60  ? 157.347 183.293 152.101 1.00 4.40  ? 60   HIS A O   1 
ATOM   380  C  CB  . HIS A 1 60  ? 154.472 182.409 150.925 1.00 4.40  ? 60   HIS A CB  1 
ATOM   381  C  CG  . HIS A 1 60  ? 155.035 181.191 151.588 1.00 4.40  ? 60   HIS A CG  1 
ATOM   382  N  ND1 . HIS A 1 60  ? 155.001 179.944 151.003 1.00 4.40  ? 60   HIS A ND1 1 
ATOM   383  C  CD2 . HIS A 1 60  ? 155.626 181.022 152.795 1.00 4.40  ? 60   HIS A CD2 1 
ATOM   384  C  CE1 . HIS A 1 60  ? 155.563 179.064 151.811 1.00 4.40  ? 60   HIS A CE1 1 
ATOM   385  N  NE2 . HIS A 1 60  ? 155.947 179.692 152.907 1.00 4.40  ? 60   HIS A NE2 1 
ATOM   386  N  N   . SER A 1 61  ? 155.839 184.936 152.400 1.00 2.42  ? 61   SER A N   1 
ATOM   387  C  CA  . SER A 1 61  ? 156.492 185.421 153.602 1.00 2.42  ? 61   SER A CA  1 
ATOM   388  C  C   . SER A 1 61  ? 156.372 184.381 154.716 1.00 2.42  ? 61   SER A C   1 
ATOM   389  O  O   . SER A 1 61  ? 155.394 183.632 154.773 1.00 2.42  ? 61   SER A O   1 
ATOM   390  C  CB  . SER A 1 61  ? 155.879 186.744 154.049 1.00 2.42  ? 61   SER A CB  1 
ATOM   391  O  OG  . SER A 1 61  ? 154.507 186.593 154.357 1.00 2.42  ? 61   SER A OG  1 
ATOM   392  N  N   . PRO A 1 62  ? 157.358 184.310 155.614 1.00 1.97  ? 62   PRO A N   1 
ATOM   393  C  CA  . PRO A 1 62  ? 157.369 183.225 156.605 1.00 1.97  ? 62   PRO A CA  1 
ATOM   394  C  C   . PRO A 1 62  ? 156.279 183.334 157.650 1.00 1.97  ? 62   PRO A C   1 
ATOM   395  O  O   . PRO A 1 62  ? 156.095 182.381 158.416 1.00 1.97  ? 62   PRO A O   1 
ATOM   396  C  CB  . PRO A 1 62  ? 158.758 183.345 157.240 1.00 1.97  ? 62   PRO A CB  1 
ATOM   397  C  CG  . PRO A 1 62  ? 159.120 184.769 157.074 1.00 1.97  ? 62   PRO A CG  1 
ATOM   398  C  CD  . PRO A 1 62  ? 158.504 185.218 155.779 1.00 1.97  ? 62   PRO A CD  1 
ATOM   399  N  N   . THR A 1 63  ? 155.561 184.451 157.720 1.00 1.81  ? 63   THR A N   1 
ATOM   400  C  CA  . THR A 1 63  ? 154.453 184.600 158.652 1.00 1.81  ? 63   THR A CA  1 
ATOM   401  C  C   . THR A 1 63  ? 153.101 184.324 158.013 1.00 1.81  ? 63   THR A C   1 
ATOM   402  O  O   . THR A 1 63  ? 152.074 184.527 158.667 1.00 1.81  ? 63   THR A O   1 
ATOM   403  C  CB  . THR A 1 63  ? 154.446 186.007 159.246 1.00 1.81  ? 63   THR A CB  1 
ATOM   404  O  OG1 . THR A 1 63  ? 154.190 186.962 158.209 1.00 1.81  ? 63   THR A OG1 1 
ATOM   405  C  CG2 . THR A 1 63  ? 155.786 186.311 159.891 1.00 1.81  ? 63   THR A CG2 1 
ATOM   406  N  N   . SER A 1 64  ? 153.073 183.882 156.758 1.00 2.56  ? 64   SER A N   1 
ATOM   407  C  CA  . SER A 1 64  ? 151.830 183.573 156.058 1.00 2.56  ? 64   SER A CA  1 
ATOM   408  C  C   . SER A 1 64  ? 151.993 182.279 155.270 1.00 2.56  ? 64   SER A C   1 
ATOM   409  O  O   . SER A 1 64  ? 151.581 182.166 154.115 1.00 2.56  ? 64   SER A O   1 
ATOM   410  C  CB  . SER A 1 64  ? 151.418 184.728 155.148 1.00 2.56  ? 64   SER A CB  1 
ATOM   411  O  OG  . SER A 1 64  ? 150.264 184.395 154.398 1.00 2.56  ? 64   SER A OG  1 
ATOM   412  N  N   . CYS A 1 65  ? 152.599 181.282 155.900 1.00 3.68  ? 65   CYS A N   1 
ATOM   413  C  CA  . CYS A 1 65  ? 152.856 180.020 155.224 1.00 3.68  ? 65   CYS A CA  1 
ATOM   414  C  C   . CYS A 1 65  ? 151.540 179.361 154.811 1.00 3.68  ? 65   CYS A C   1 
ATOM   415  O  O   . CYS A 1 65  ? 150.595 179.322 155.610 1.00 3.68  ? 65   CYS A O   1 
ATOM   416  C  CB  . CYS A 1 65  ? 153.648 179.082 156.136 1.00 3.68  ? 65   CYS A CB  1 
ATOM   417  S  SG  . CYS A 1 65  ? 155.437 179.362 156.134 1.00 3.68  ? 65   CYS A SG  1 
ATOM   418  N  N   . PRO A 1 66  ? 151.423 178.874 153.579 1.00 4.00  ? 66   PRO A N   1 
ATOM   419  C  CA  . PRO A 1 66  ? 150.294 178.009 153.223 1.00 4.00  ? 66   PRO A CA  1 
ATOM   420  C  C   . PRO A 1 66  ? 150.387 176.674 153.936 1.00 4.00  ? 66   PRO A C   1 
ATOM   421  O  O   . PRO A 1 66  ? 151.482 176.252 154.337 1.00 4.00  ? 66   PRO A O   1 
ATOM   422  C  CB  . PRO A 1 66  ? 150.435 177.825 151.703 1.00 4.00  ? 66   PRO A CB  1 
ATOM   423  C  CG  . PRO A 1 66  ? 151.445 178.802 151.242 1.00 4.00  ? 66   PRO A CG  1 
ATOM   424  C  CD  . PRO A 1 66  ? 152.072 179.478 152.406 1.00 4.00  ? 66   PRO A CD  1 
ATOM   425  N  N   . PRO A 1 67  ? 149.251 175.958 154.045 1.00 3.87  ? 67   PRO A N   1 
ATOM   426  C  CA  . PRO A 1 67  ? 149.300 174.669 154.748 1.00 3.87  ? 67   PRO A CA  1 
ATOM   427  C  C   . PRO A 1 67  ? 150.246 173.664 154.095 1.00 3.87  ? 67   PRO A C   1 
ATOM   428  O  O   . PRO A 1 67  ? 150.780 172.801 154.792 1.00 3.87  ? 67   PRO A O   1 
ATOM   429  C  CB  . PRO A 1 67  ? 147.852 174.171 154.700 1.00 3.87  ? 67   PRO A CB  1 
ATOM   430  C  CG  . PRO A 1 67  ? 147.209 174.908 153.582 1.00 3.87  ? 67   PRO A CG  1 
ATOM   431  C  CD  . PRO A 1 67  ? 147.938 176.207 153.417 1.00 3.87  ? 67   PRO A CD  1 
ATOM   432  N  N   . THR A 1 68  ? 150.452 173.768 152.785 1.00 4.35  ? 68   THR A N   1 
ATOM   433  C  CA  . THR A 1 68  ? 151.363 172.854 152.101 1.00 4.35  ? 68   THR A CA  1 
ATOM   434  C  C   . THR A 1 68  ? 152.800 173.058 152.566 1.00 4.35  ? 68   THR A C   1 
ATOM   435  O  O   . THR A 1 68  ? 153.573 172.097 152.668 1.00 4.35  ? 68   THR A O   1 
ATOM   436  C  CB  . THR A 1 68  ? 151.259 173.039 150.588 1.00 4.35  ? 68   THR A CB  1 
ATOM   437  N  N   . CYS A 1 69  ? 153.171 174.299 152.853 1.00 3.57  ? 69   CYS A N   1 
ATOM   438  C  CA  . CYS A 1 69  ? 154.546 174.601 153.225 1.00 3.57  ? 69   CYS A CA  1 
ATOM   439  C  C   . CYS A 1 69  ? 154.883 173.958 154.568 1.00 3.57  ? 69   CYS A C   1 
ATOM   440  O  O   . CYS A 1 69  ? 154.033 173.916 155.465 1.00 3.57  ? 69   CYS A O   1 
ATOM   441  C  CB  . CYS A 1 69  ? 154.745 176.114 153.303 1.00 3.57  ? 69   CYS A CB  1 
ATOM   442  S  SG  . CYS A 1 69  ? 156.427 176.627 153.690 1.00 3.57  ? 69   CYS A SG  1 
ATOM   443  N  N   . PRO A 1 70  ? 156.104 173.447 154.746 1.00 3.33  ? 70   PRO A N   1 
ATOM   444  C  CA  . PRO A 1 70  ? 156.459 172.852 156.044 1.00 3.33  ? 70   PRO A CA  1 
ATOM   445  C  C   . PRO A 1 70  ? 156.494 173.848 157.183 1.00 3.33  ? 70   PRO A C   1 
ATOM   446  O  O   . PRO A 1 70  ? 156.435 173.435 158.347 1.00 3.33  ? 70   PRO A O   1 
ATOM   447  C  CB  . PRO A 1 70  ? 157.848 172.248 155.786 1.00 3.33  ? 70   PRO A CB  1 
ATOM   448  C  CG  . PRO A 1 70  ? 158.382 172.994 154.617 1.00 3.33  ? 70   PRO A CG  1 
ATOM   449  C  CD  . PRO A 1 70  ? 157.199 173.327 153.769 1.00 3.33  ? 70   PRO A CD  1 
ATOM   450  N  N   . GLY A 1 71  ? 156.592 175.146 156.893 1.00 3.77  ? 71   GLY A N   1 
ATOM   451  C  CA  . GLY A 1 71  ? 156.638 176.138 157.952 1.00 3.77  ? 71   GLY A CA  1 
ATOM   452  C  C   . GLY A 1 71  ? 155.307 176.375 158.631 1.00 3.77  ? 71   GLY A C   1 
ATOM   453  O  O   . GLY A 1 71  ? 155.276 176.970 159.713 1.00 3.77  ? 71   GLY A O   1 
ATOM   454  N  N   . TYR A 1 72  ? 154.208 175.915 158.028 1.00 4.51  ? 72   TYR A N   1 
ATOM   455  C  CA  . TYR A 1 72  ? 152.891 176.148 158.610 1.00 4.51  ? 72   TYR A CA  1 
ATOM   456  C  C   . TYR A 1 72  ? 152.803 175.597 160.023 1.00 4.51  ? 72   TYR A C   1 
ATOM   457  O  O   . TYR A 1 72  ? 152.162 176.196 160.892 1.00 4.51  ? 72   TYR A O   1 
ATOM   458  C  CB  . TYR A 1 72  ? 151.809 175.532 157.726 1.00 4.51  ? 72   TYR A CB  1 
ATOM   459  C  CG  . TYR A 1 72  ? 150.428 176.080 157.982 1.00 4.51  ? 72   TYR A CG  1 
ATOM   460  C  CD1 . TYR A 1 72  ? 149.708 175.709 159.105 1.00 4.51  ? 72   TYR A CD1 1 
ATOM   461  C  CD2 . TYR A 1 72  ? 149.856 176.991 157.115 1.00 4.51  ? 72   TYR A CD2 1 
ATOM   462  C  CE1 . TYR A 1 72  ? 148.446 176.213 159.340 1.00 4.51  ? 72   TYR A CE1 1 
ATOM   463  C  CE2 . TYR A 1 72  ? 148.596 177.500 157.341 1.00 4.51  ? 72   TYR A CE2 1 
ATOM   464  C  CZ  . TYR A 1 72  ? 147.897 177.111 158.456 1.00 4.51  ? 72   TYR A CZ  1 
ATOM   465  O  OH  . TYR A 1 72  ? 146.642 177.623 158.684 1.00 4.51  ? 72   TYR A OH  1 
ATOM   466  N  N   . ARG A 1 73  ? 153.429 174.454 160.276 1.00 5.92  ? 73   ARG A N   1 
ATOM   467  C  CA  . ARG A 1 73  ? 153.525 173.983 161.647 1.00 5.92  ? 73   ARG A CA  1 
ATOM   468  C  C   . ARG A 1 73  ? 154.297 175.022 162.443 1.00 5.92  ? 73   ARG A C   1 
ATOM   469  O  O   . ARG A 1 73  ? 153.757 175.642 163.366 1.00 5.92  ? 73   ARG A O   1 
ATOM   470  C  CB  . ARG A 1 73  ? 154.205 172.614 161.723 1.00 5.92  ? 73   ARG A CB  1 
ATOM   471  C  CG  . ARG A 1 73  ? 153.677 171.746 162.852 1.00 5.92  ? 73   ARG A CG  1 
ATOM   472  C  CD  . ARG A 1 73  ? 154.744 170.835 163.447 1.00 5.92  ? 73   ARG A CD  1 
ATOM   473  N  NE  . ARG A 1 73  ? 155.765 171.554 164.204 1.00 5.92  ? 73   ARG A NE  1 
ATOM   474  C  CZ  . ARG A 1 73  ? 155.548 172.252 165.313 1.00 5.92  ? 73   ARG A CZ  1 
ATOM   475  N  NH1 . ARG A 1 73  ? 154.340 172.363 165.841 1.00 5.92  ? 73   ARG A NH1 1 
ATOM   476  N  NH2 . ARG A 1 73  ? 156.573 172.848 165.913 1.00 5.92  ? 73   ARG A NH2 1 
ATOM   477  N  N   . TRP A 1 74  ? 155.550 175.250 162.046 1.00 2.89  ? 74   TRP A N   1 
ATOM   478  C  CA  . TRP A 1 74  ? 156.410 176.198 162.744 1.00 2.89  ? 74   TRP A CA  1 
ATOM   479  C  C   . TRP A 1 74  ? 155.688 177.515 162.983 1.00 2.89  ? 74   TRP A C   1 
ATOM   480  O  O   . TRP A 1 74  ? 155.526 177.956 164.126 1.00 2.89  ? 74   TRP A O   1 
ATOM   481  C  CB  . TRP A 1 74  ? 157.681 176.424 161.930 1.00 2.89  ? 74   TRP A CB  1 
ATOM   482  C  CG  . TRP A 1 74  ? 158.740 175.439 162.231 1.00 2.89  ? 74   TRP A CG  1 
ATOM   483  C  CD1 . TRP A 1 74  ? 159.259 174.513 161.380 1.00 2.89  ? 74   TRP A CD1 1 
ATOM   484  C  CD2 . TRP A 1 74  ? 159.417 175.267 163.476 1.00 2.89  ? 74   TRP A CD2 1 
ATOM   485  N  NE1 . TRP A 1 74  ? 160.222 173.773 162.018 1.00 2.89  ? 74   TRP A NE1 1 
ATOM   486  C  CE2 . TRP A 1 74  ? 160.338 174.219 163.308 1.00 2.89  ? 74   TRP A CE2 1 
ATOM   487  C  CE3 . TRP A 1 74  ? 159.335 175.900 164.717 1.00 2.89  ? 74   TRP A CE3 1 
ATOM   488  C  CZ2 . TRP A 1 74  ? 161.170 173.790 164.332 1.00 2.89  ? 74   TRP A CZ2 1 
ATOM   489  C  CZ3 . TRP A 1 74  ? 160.160 175.473 165.731 1.00 2.89  ? 74   TRP A CZ3 1 
ATOM   490  C  CH2 . TRP A 1 74  ? 161.066 174.428 165.535 1.00 2.89  ? 74   TRP A CH2 1 
ATOM   491  N  N   . MET A 1 75  ? 155.214 178.142 161.905 1.00 2.88  ? 75   MET A N   1 
ATOM   492  C  CA  . MET A 1 75  ? 154.534 179.421 162.049 1.00 2.88  ? 75   MET A CA  1 
ATOM   493  C  C   . MET A 1 75  ? 153.441 179.326 163.099 1.00 2.88  ? 75   MET A C   1 
ATOM   494  O  O   . MET A 1 75  ? 153.414 180.122 164.047 1.00 2.88  ? 75   MET A O   1 
ATOM   495  C  CB  . MET A 1 75  ? 153.960 179.862 160.702 1.00 2.88  ? 75   MET A CB  1 
ATOM   496  C  CG  . MET A 1 75  ? 153.064 181.097 160.746 1.00 2.88  ? 75   MET A CG  1 
ATOM   497  S  SD  . MET A 1 75  ? 151.717 181.046 159.554 1.00 2.88  ? 75   MET A SD  1 
ATOM   498  C  CE  . MET A 1 75  ? 150.872 179.548 160.045 1.00 2.88  ? 75   MET A CE  1 
ATOM   499  N  N   . CYS A 1 76  ? 152.574 178.318 162.991 1.00 3.52  ? 76   CYS A N   1 
ATOM   500  C  CA  . CYS A 1 76  ? 151.480 178.206 163.945 1.00 3.52  ? 76   CYS A CA  1 
ATOM   501  C  C   . CYS A 1 76  ? 152.015 178.304 165.360 1.00 3.52  ? 76   CYS A C   1 
ATOM   502  O  O   . CYS A 1 76  ? 151.551 179.128 166.158 1.00 3.52  ? 76   CYS A O   1 
ATOM   503  C  CB  . CYS A 1 76  ? 150.729 176.892 163.739 1.00 3.52  ? 76   CYS A CB  1 
ATOM   504  S  SG  . CYS A 1 76  ? 149.636 176.895 162.308 1.00 3.52  ? 76   CYS A SG  1 
ATOM   505  N  N   . LEU A 1 77  ? 153.053 177.522 165.663 1.00 2.36  ? 77   LEU A N   1 
ATOM   506  C  CA  . LEU A 1 77  ? 153.651 177.561 166.987 1.00 2.36  ? 77   LEU A CA  1 
ATOM   507  C  C   . LEU A 1 77  ? 153.831 178.999 167.438 1.00 2.36  ? 77   LEU A C   1 
ATOM   508  O  O   . LEU A 1 77  ? 153.175 179.456 168.381 1.00 2.36  ? 77   LEU A O   1 
ATOM   509  C  CB  . LEU A 1 77  ? 154.996 176.831 166.980 1.00 2.36  ? 77   LEU A CB  1 
ATOM   510  C  CG  . LEU A 1 77  ? 155.683 176.722 168.339 1.00 2.36  ? 77   LEU A CG  1 
ATOM   511  C  CD1 . LEU A 1 77  ? 154.842 175.895 169.291 1.00 2.36  ? 77   LEU A CD1 1 
ATOM   512  C  CD2 . LEU A 1 77  ? 157.068 176.128 168.189 1.00 2.36  ? 77   LEU A CD2 1 
ATOM   513  N  N   . ARG A 1 78  ? 154.663 179.753 166.721 1.00 1.69  ? 78   ARG A N   1 
ATOM   514  C  CA  . ARG A 1 78  ? 154.960 181.102 167.179 1.00 1.69  ? 78   ARG A CA  1 
ATOM   515  C  C   . ARG A 1 78  ? 153.707 181.958 167.164 1.00 1.69  ? 78   ARG A C   1 
ATOM   516  O  O   . ARG A 1 78  ? 153.467 182.732 168.098 1.00 1.69  ? 78   ARG A O   1 
ATOM   517  C  CB  . ARG A 1 78  ? 156.076 181.721 166.341 1.00 1.69  ? 78   ARG A CB  1 
ATOM   518  C  CG  . ARG A 1 78  ? 155.856 181.712 164.862 1.00 1.69  ? 78   ARG A CG  1 
ATOM   519  C  CD  . ARG A 1 78  ? 156.874 182.596 164.192 1.00 1.69  ? 78   ARG A CD  1 
ATOM   520  N  NE  . ARG A 1 78  ? 156.498 182.923 162.827 1.00 1.69  ? 78   ARG A NE  1 
ATOM   521  C  CZ  . ARG A 1 78  ? 156.790 182.171 161.777 1.00 1.69  ? 78   ARG A CZ  1 
ATOM   522  N  NH1 . ARG A 1 78  ? 157.425 181.018 161.905 1.00 1.69  ? 78   ARG A NH1 1 
ATOM   523  N  NH2 . ARG A 1 78  ? 156.432 182.581 160.568 1.00 1.69  ? 78   ARG A NH2 1 
ATOM   524  N  N   . ARG A 1 79  ? 152.865 181.796 166.144 1.00 2.07  ? 79   ARG A N   1 
ATOM   525  C  CA  . ARG A 1 79  ? 151.594 182.505 166.153 1.00 2.07  ? 79   ARG A CA  1 
ATOM   526  C  C   . ARG A 1 79  ? 150.851 182.211 167.445 1.00 2.07  ? 79   ARG A C   1 
ATOM   527  O  O   . ARG A 1 79  ? 150.489 183.127 168.194 1.00 2.07  ? 79   ARG A O   1 
ATOM   528  C  CB  . ARG A 1 79  ? 150.760 182.110 164.936 1.00 2.07  ? 79   ARG A CB  1 
ATOM   529  C  CG  . ARG A 1 79  ? 149.741 183.154 164.548 1.00 2.07  ? 79   ARG A CG  1 
ATOM   530  C  CD  . ARG A 1 79  ? 150.222 183.999 163.383 1.00 2.07  ? 79   ARG A CD  1 
ATOM   531  N  NE  . ARG A 1 79  ? 150.249 183.266 162.125 1.00 2.07  ? 79   ARG A NE  1 
ATOM   532  C  CZ  . ARG A 1 79  ? 149.187 183.049 161.362 1.00 2.07  ? 79   ARG A CZ  1 
ATOM   533  N  NH1 . ARG A 1 79  ? 147.986 183.480 161.710 1.00 2.07  ? 79   ARG A NH1 1 
ATOM   534  N  NH2 . ARG A 1 79  ? 149.333 182.387 160.219 1.00 2.07  ? 79   ARG A NH2 1 
ATOM   535  N  N   . PHE A 1 80  ? 150.693 180.926 167.765 1.00 1.95  ? 80   PHE A N   1 
ATOM   536  C  CA  . PHE A 1 80  ? 150.068 180.556 169.026 1.00 1.95  ? 80   PHE A CA  1 
ATOM   537  C  C   . PHE A 1 80  ? 150.770 181.241 170.188 1.00 1.95  ? 80   PHE A C   1 
ATOM   538  O  O   . PHE A 1 80  ? 150.125 181.858 171.044 1.00 1.95  ? 80   PHE A O   1 
ATOM   539  C  CB  . PHE A 1 80  ? 150.091 179.038 169.193 1.00 1.95  ? 80   PHE A CB  1 
ATOM   540  C  CG  . PHE A 1 80  ? 149.568 178.568 170.512 1.00 1.95  ? 80   PHE A CG  1 
ATOM   541  C  CD1 . PHE A 1 80  ? 148.224 178.297 170.680 1.00 1.95  ? 80   PHE A CD1 1 
ATOM   542  C  CD2 . PHE A 1 80  ? 150.423 178.380 171.580 1.00 1.95  ? 80   PHE A CD2 1 
ATOM   543  C  CE1 . PHE A 1 80  ? 147.742 177.862 171.893 1.00 1.95  ? 80   PHE A CE1 1 
ATOM   544  C  CE2 . PHE A 1 80  ? 149.947 177.944 172.794 1.00 1.95  ? 80   PHE A CE2 1 
ATOM   545  C  CZ  . PHE A 1 80  ? 148.605 177.685 172.953 1.00 1.95  ? 80   PHE A CZ  1 
ATOM   546  N  N   . ILE A 1 81  ? 152.102 181.184 170.212 1.00 1.80  ? 81   ILE A N   1 
ATOM   547  C  CA  . ILE A 1 81  ? 152.836 181.824 171.298 1.00 1.80  ? 81   ILE A CA  1 
ATOM   548  C  C   . ILE A 1 81  ? 152.455 183.293 171.369 1.00 1.80  ? 81   ILE A C   1 
ATOM   549  O  O   . ILE A 1 81  ? 152.070 183.806 172.427 1.00 1.80  ? 81   ILE A O   1 
ATOM   550  C  CB  . ILE A 1 81  ? 154.351 181.637 171.108 1.00 1.80  ? 81   ILE A CB  1 
ATOM   551  C  CG1 . ILE A 1 81  ? 154.760 180.229 171.531 1.00 1.80  ? 81   ILE A CG1 1 
ATOM   552  C  CG2 . ILE A 1 81  ? 155.121 182.667 171.912 1.00 1.80  ? 81   ILE A CG2 1 
ATOM   553  C  CD1 . ILE A 1 81  ? 155.971 179.712 170.808 1.00 1.80  ? 81   ILE A CD1 1 
ATOM   554  N  N   . ILE A 1 82  ? 152.494 183.977 170.225 1.00 1.85  ? 82   ILE A N   1 
ATOM   555  C  CA  . ILE A 1 82  ? 152.110 185.383 170.207 1.00 1.85  ? 82   ILE A CA  1 
ATOM   556  C  C   . ILE A 1 82  ? 150.708 185.532 170.771 1.00 1.85  ? 82   ILE A C   1 
ATOM   557  O  O   . ILE A 1 82  ? 150.456 186.359 171.654 1.00 1.85  ? 82   ILE A O   1 
ATOM   558  C  CB  . ILE A 1 82  ? 152.213 185.950 168.781 1.00 1.85  ? 82   ILE A CB  1 
ATOM   559  C  CG1 . ILE A 1 82  ? 153.659 186.335 168.480 1.00 1.85  ? 82   ILE A CG1 1 
ATOM   560  C  CG2 . ILE A 1 82  ? 151.307 187.154 168.618 1.00 1.85  ? 82   ILE A CG2 1 
ATOM   561  C  CD1 . ILE A 1 82  ? 153.950 186.517 167.019 1.00 1.85  ? 82   ILE A CD1 1 
ATOM   562  N  N   . PHE A 1 83  ? 149.790 184.682 170.313 1.00 2.05  ? 83   PHE A N   1 
ATOM   563  C  CA  . PHE A 1 83  ? 148.424 184.730 170.813 1.00 2.05  ? 83   PHE A CA  1 
ATOM   564  C  C   . PHE A 1 83  ? 148.417 184.687 172.334 1.00 2.05  ? 83   PHE A C   1 
ATOM   565  O  O   . PHE A 1 83  ? 147.807 185.541 172.987 1.00 2.05  ? 83   PHE A O   1 
ATOM   566  C  CB  . PHE A 1 83  ? 147.626 183.572 170.212 1.00 2.05  ? 83   PHE A CB  1 
ATOM   567  C  CG  . PHE A 1 83  ? 146.371 183.238 170.956 1.00 2.05  ? 83   PHE A CG  1 
ATOM   568  C  CD1 . PHE A 1 83  ? 145.224 183.986 170.772 1.00 2.05  ? 83   PHE A CD1 1 
ATOM   569  C  CD2 . PHE A 1 83  ? 146.333 182.163 171.826 1.00 2.05  ? 83   PHE A CD2 1 
ATOM   570  C  CE1 . PHE A 1 83  ? 144.065 183.673 171.445 1.00 2.05  ? 83   PHE A CE1 1 
ATOM   571  C  CE2 . PHE A 1 83  ? 145.177 181.847 172.505 1.00 2.05  ? 83   PHE A CE2 1 
ATOM   572  C  CZ  . PHE A 1 83  ? 144.041 182.604 172.314 1.00 2.05  ? 83   PHE A CZ  1 
ATOM   573  N  N   . LEU A 1 84  ? 149.152 183.739 172.920 1.00 2.07  ? 84   LEU A N   1 
ATOM   574  C  CA  . LEU A 1 84  ? 149.205 183.662 174.375 1.00 2.07  ? 84   LEU A CA  1 
ATOM   575  C  C   . LEU A 1 84  ? 149.614 184.999 174.968 1.00 2.07  ? 84   LEU A C   1 
ATOM   576  O  O   . LEU A 1 84  ? 148.926 185.544 175.839 1.00 2.07  ? 84   LEU A O   1 
ATOM   577  C  CB  . LEU A 1 84  ? 150.174 182.569 174.822 1.00 2.07  ? 84   LEU A CB  1 
ATOM   578  C  CG  . LEU A 1 84  ? 149.617 181.151 174.867 1.00 2.07  ? 84   LEU A CG  1 
ATOM   579  C  CD1 . LEU A 1 84  ? 150.755 180.155 174.964 1.00 2.07  ? 84   LEU A CD1 1 
ATOM   580  C  CD2 . LEU A 1 84  ? 148.662 181.001 176.034 1.00 2.07  ? 84   LEU A CD2 1 
ATOM   581  N  N   . PHE A 1 85  ? 150.721 185.561 174.481 1.00 2.47  ? 85   PHE A N   1 
ATOM   582  C  CA  . PHE A 1 85  ? 151.202 186.817 175.035 1.00 2.47  ? 85   PHE A CA  1 
ATOM   583  C  C   . PHE A 1 85  ? 150.089 187.851 175.039 1.00 2.47  ? 85   PHE A C   1 
ATOM   584  O  O   . PHE A 1 85  ? 149.900 188.574 176.024 1.00 2.47  ? 85   PHE A O   1 
ATOM   585  C  CB  . PHE A 1 85  ? 152.409 187.317 174.240 1.00 2.47  ? 85   PHE A CB  1 
ATOM   586  C  CG  . PHE A 1 85  ? 153.713 186.698 174.662 1.00 2.47  ? 85   PHE A CG  1 
ATOM   587  C  CD1 . PHE A 1 85  ? 154.053 186.593 176.001 1.00 2.47  ? 85   PHE A CD1 1 
ATOM   588  C  CD2 . PHE A 1 85  ? 154.597 186.211 173.717 1.00 2.47  ? 85   PHE A CD2 1 
ATOM   589  C  CE1 . PHE A 1 85  ? 155.246 186.020 176.386 1.00 2.47  ? 85   PHE A CE1 1 
ATOM   590  C  CE2 . PHE A 1 85  ? 155.793 185.637 174.098 1.00 2.47  ? 85   PHE A CE2 1 
ATOM   591  C  CZ  . PHE A 1 85  ? 156.116 185.541 175.434 1.00 2.47  ? 85   PHE A CZ  1 
ATOM   592  N  N   . ILE A 1 86  ? 149.301 187.897 173.962 1.00 2.75  ? 86   ILE A N   1 
ATOM   593  C  CA  . ILE A 1 86  ? 148.239 188.897 173.879 1.00 2.75  ? 86   ILE A CA  1 
ATOM   594  C  C   . ILE A 1 86  ? 147.323 188.765 175.084 1.00 2.75  ? 86   ILE A C   1 
ATOM   595  O  O   . ILE A 1 86  ? 147.088 189.729 175.823 1.00 2.75  ? 86   ILE A O   1 
ATOM   596  C  CB  . ILE A 1 86  ? 147.455 188.750 172.564 1.00 2.75  ? 86   ILE A CB  1 
ATOM   597  C  CG1 . ILE A 1 86  ? 148.388 188.894 171.364 1.00 2.75  ? 86   ILE A CG1 1 
ATOM   598  C  CG2 . ILE A 1 86  ? 146.354 189.788 172.491 1.00 2.75  ? 86   ILE A CG2 1 
ATOM   599  C  CD1 . ILE A 1 86  ? 149.119 190.208 171.295 1.00 2.75  ? 86   ILE A CD1 1 
ATOM   600  N  N   . LEU A 1 87  ? 146.841 187.547 175.337 1.00 2.75  ? 87   LEU A N   1 
ATOM   601  C  CA  . LEU A 1 87  ? 146.013 187.330 176.515 1.00 2.75  ? 87   LEU A CA  1 
ATOM   602  C  C   . LEU A 1 87  ? 146.719 187.848 177.755 1.00 2.75  ? 87   LEU A C   1 
ATOM   603  O  O   . LEU A 1 87  ? 146.160 188.647 178.515 1.00 2.75  ? 87   LEU A O   1 
ATOM   604  C  CB  . LEU A 1 87  ? 145.672 185.848 176.661 1.00 2.75  ? 87   LEU A CB  1 
ATOM   605  C  CG  . LEU A 1 87  ? 144.572 185.340 175.733 1.00 2.75  ? 87   LEU A CG  1 
ATOM   606  C  CD1 . LEU A 1 87  ? 145.050 185.266 174.302 1.00 2.75  ? 87   LEU A CD1 1 
ATOM   607  C  CD2 . LEU A 1 87  ? 144.083 183.982 176.199 1.00 2.75  ? 87   LEU A CD2 1 
ATOM   608  N  N   . LEU A 1 88  ? 147.977 187.447 177.944 1.00 3.78  ? 88   LEU A N   1 
ATOM   609  C  CA  . LEU A 1 88  ? 148.728 187.945 179.087 1.00 3.78  ? 88   LEU A CA  1 
ATOM   610  C  C   . LEU A 1 88  ? 148.698 189.463 179.104 1.00 3.78  ? 88   LEU A C   1 
ATOM   611  O  O   . LEU A 1 88  ? 148.288 190.077 180.096 1.00 3.78  ? 88   LEU A O   1 
ATOM   612  C  CB  . LEU A 1 88  ? 150.166 187.430 179.042 1.00 3.78  ? 88   LEU A CB  1 
ATOM   613  C  CG  . LEU A 1 88  ? 151.002 187.753 180.279 1.00 3.78  ? 88   LEU A CG  1 
ATOM   614  C  CD1 . LEU A 1 88  ? 150.417 187.061 181.496 1.00 3.78  ? 88   LEU A CD1 1 
ATOM   615  C  CD2 . LEU A 1 88  ? 152.450 187.344 180.075 1.00 3.78  ? 88   LEU A CD2 1 
ATOM   616  N  N   . LEU A 1 89  ? 149.061 190.086 177.982 1.00 3.87  ? 89   LEU A N   1 
ATOM   617  C  CA  . LEU A 1 89  ? 148.979 191.536 177.902 1.00 3.87  ? 89   LEU A CA  1 
ATOM   618  C  C   . LEU A 1 89  ? 147.585 192.000 178.288 1.00 3.87  ? 89   LEU A C   1 
ATOM   619  O  O   . LEU A 1 89  ? 147.417 192.817 179.201 1.00 3.87  ? 89   LEU A O   1 
ATOM   620  C  CB  . LEU A 1 89  ? 149.338 192.008 176.494 1.00 3.87  ? 89   LEU A CB  1 
ATOM   621  C  CG  . LEU A 1 89  ? 150.805 192.372 176.272 1.00 3.87  ? 89   LEU A CG  1 
ATOM   622  C  CD1 . LEU A 1 89  ? 151.665 191.125 176.198 1.00 3.87  ? 89   LEU A CD1 1 
ATOM   623  C  CD2 . LEU A 1 89  ? 150.955 193.202 175.009 1.00 3.87  ? 89   LEU A CD2 1 
ATOM   624  N  N   . CYS A 1 90  ? 146.565 191.430 177.647 1.00 4.72  ? 90   CYS A N   1 
ATOM   625  C  CA  . CYS A 1 90  ? 145.197 191.790 177.990 1.00 4.72  ? 90   CYS A CA  1 
ATOM   626  C  C   . CYS A 1 90  ? 144.974 191.634 179.485 1.00 4.72  ? 90   CYS A C   1 
ATOM   627  O  O   . CYS A 1 90  ? 144.493 192.556 180.155 1.00 4.72  ? 90   CYS A O   1 
ATOM   628  C  CB  . CYS A 1 90  ? 144.213 190.929 177.198 1.00 4.72  ? 90   CYS A CB  1 
ATOM   629  S  SG  . CYS A 1 90  ? 143.864 191.557 175.543 1.00 4.72  ? 90   CYS A SG  1 
ATOM   630  N  N   . LEU A 1 91  ? 145.370 190.486 180.037 1.00 6.06  ? 91   LEU A N   1 
ATOM   631  C  CA  . LEU A 1 91  ? 145.206 190.277 181.468 1.00 6.06  ? 91   LEU A CA  1 
ATOM   632  C  C   . LEU A 1 91  ? 145.876 191.398 182.243 1.00 6.06  ? 91   LEU A C   1 
ATOM   633  O  O   . LEU A 1 91  ? 145.256 192.031 183.106 1.00 6.06  ? 91   LEU A O   1 
ATOM   634  C  CB  . LEU A 1 91  ? 145.776 188.920 181.879 1.00 6.06  ? 91   LEU A CB  1 
ATOM   635  C  CG  . LEU A 1 91  ? 145.048 188.265 183.052 1.00 6.06  ? 91   LEU A CG  1 
ATOM   636  C  CD1 . LEU A 1 91  ? 143.656 187.812 182.633 1.00 6.06  ? 91   LEU A CD1 1 
ATOM   637  C  CD2 . LEU A 1 91  ? 145.852 187.103 183.604 1.00 6.06  ? 91   LEU A CD2 1 
ATOM   638  N  N   . ILE A 1 92  ? 147.138 191.690 181.917 1.00 5.77  ? 92   ILE A N   1 
ATOM   639  C  CA  . ILE A 1 92  ? 147.812 192.816 182.556 1.00 5.77  ? 92   ILE A CA  1 
ATOM   640  C  C   . ILE A 1 92  ? 146.929 194.048 182.452 1.00 5.77  ? 92   ILE A C   1 
ATOM   641  O  O   . ILE A 1 92  ? 146.544 194.652 183.461 1.00 5.77  ? 92   ILE A O   1 
ATOM   642  C  CB  . ILE A 1 92  ? 149.190 193.060 181.919 1.00 5.77  ? 92   ILE A CB  1 
ATOM   643  C  CG1 . ILE A 1 92  ? 150.105 191.849 182.115 1.00 5.77  ? 92   ILE A CG1 1 
ATOM   644  C  CG2 . ILE A 1 92  ? 149.829 194.303 182.509 1.00 5.77  ? 92   ILE A CG2 1 
ATOM   645  C  CD1 . ILE A 1 92  ? 150.386 191.502 183.554 1.00 5.77  ? 92   ILE A CD1 1 
ATOM   646  N  N   . PHE A 1 93  ? 146.530 194.385 181.225 1.00 7.61  ? 93   PHE A N   1 
ATOM   647  C  CA  . PHE A 1 93  ? 145.651 195.526 181.020 1.00 7.61  ? 93   PHE A CA  1 
ATOM   648  C  C   . PHE A 1 93  ? 144.441 195.428 181.937 1.00 7.61  ? 93   PHE A C   1 
ATOM   649  O  O   . PHE A 1 93  ? 144.142 196.357 182.696 1.00 7.61  ? 93   PHE A O   1 
ATOM   650  C  CB  . PHE A 1 93  ? 145.224 195.593 179.552 1.00 7.61  ? 93   PHE A CB  1 
ATOM   651  C  CG  . PHE A 1 93  ? 144.465 196.838 179.192 1.00 7.61  ? 93   PHE A CG  1 
ATOM   652  C  CD1 . PHE A 1 93  ? 143.125 196.967 179.517 1.00 7.61  ? 93   PHE A CD1 1 
ATOM   653  C  CD2 . PHE A 1 93  ? 145.089 197.875 178.522 1.00 7.61  ? 93   PHE A CD2 1 
ATOM   654  C  CE1 . PHE A 1 93  ? 142.424 198.109 179.182 1.00 7.61  ? 93   PHE A CE1 1 
ATOM   655  C  CE2 . PHE A 1 93  ? 144.393 199.020 178.185 1.00 7.61  ? 93   PHE A CE2 1 
ATOM   656  C  CZ  . PHE A 1 93  ? 143.059 199.137 178.516 1.00 7.61  ? 93   PHE A CZ  1 
ATOM   657  N  N   . LEU A 1 94  ? 143.768 194.276 181.925 1.00 8.38  ? 94   LEU A N   1 
ATOM   658  C  CA  . LEU A 1 94  ? 142.591 194.117 182.767 1.00 8.38  ? 94   LEU A CA  1 
ATOM   659  C  C   . LEU A 1 94  ? 142.943 194.394 184.221 1.00 8.38  ? 94   LEU A C   1 
ATOM   660  O  O   . LEU A 1 94  ? 142.288 195.202 184.889 1.00 8.38  ? 94   LEU A O   1 
ATOM   661  C  CB  . LEU A 1 94  ? 142.008 192.714 182.603 1.00 8.38  ? 94   LEU A CB  1 
ATOM   662  C  CG  . LEU A 1 94  ? 140.741 192.442 183.414 1.00 8.38  ? 94   LEU A CG  1 
ATOM   663  C  CD1 . LEU A 1 94  ? 139.564 193.188 182.811 1.00 8.38  ? 94   LEU A CD1 1 
ATOM   664  C  CD2 . LEU A 1 94  ? 140.451 190.952 183.483 1.00 8.38  ? 94   LEU A CD2 1 
ATOM   665  N  N   . LEU A 1 95  ? 144.009 193.766 184.715 1.00 9.07  ? 95   LEU A N   1 
ATOM   666  C  CA  . LEU A 1 95  ? 144.448 194.060 186.072 1.00 9.07  ? 95   LEU A CA  1 
ATOM   667  C  C   . LEU A 1 95  ? 144.782 195.538 186.205 1.00 9.07  ? 95   LEU A C   1 
ATOM   668  O  O   . LEU A 1 95  ? 144.298 196.221 187.116 1.00 9.07  ? 95   LEU A O   1 
ATOM   669  C  CB  . LEU A 1 95  ? 145.654 193.195 186.432 1.00 9.07  ? 95   LEU A CB  1 
ATOM   670  C  CG  . LEU A 1 95  ? 145.388 191.692 186.515 1.00 9.07  ? 95   LEU A CG  1 
ATOM   671  C  CD1 . LEU A 1 95  ? 146.688 190.933 186.714 1.00 9.07  ? 95   LEU A CD1 1 
ATOM   672  C  CD2 . LEU A 1 95  ? 144.405 191.378 187.629 1.00 9.07  ? 95   LEU A CD2 1 
ATOM   673  N  N   . VAL A 1 96  ? 145.563 196.064 185.258 1.00 8.72  ? 96   VAL A N   1 
ATOM   674  C  CA  . VAL A 1 96  ? 145.949 197.465 185.297 1.00 8.72  ? 96   VAL A CA  1 
ATOM   675  C  C   . VAL A 1 96  ? 144.729 198.366 185.280 1.00 8.72  ? 96   VAL A C   1 
ATOM   676  O  O   . VAL A 1 96  ? 144.822 199.539 185.655 1.00 8.72  ? 96   VAL A O   1 
ATOM   677  C  CB  . VAL A 1 96  ? 146.897 197.787 184.124 1.00 8.72  ? 96   VAL A CB  1 
ATOM   678  C  CG1 . VAL A 1 96  ? 147.150 199.284 184.037 1.00 8.72  ? 96   VAL A CG1 1 
ATOM   679  C  CG2 . VAL A 1 96  ? 148.212 197.038 184.290 1.00 8.72  ? 96   VAL A CG2 1 
ATOM   680  N  N   . LEU A 1 97  ? 143.578 197.849 184.852 1.00 10.12 ? 97   LEU A N   1 
ATOM   681  C  CA  . LEU A 1 97  ? 142.353 198.633 184.927 1.00 10.12 ? 97   LEU A CA  1 
ATOM   682  C  C   . LEU A 1 97  ? 141.674 198.440 186.278 1.00 10.12 ? 97   LEU A C   1 
ATOM   683  O  O   . LEU A 1 97  ? 141.290 199.412 186.937 1.00 10.12 ? 97   LEU A O   1 
ATOM   684  C  CB  . LEU A 1 97  ? 141.417 198.249 183.778 1.00 10.12 ? 97   LEU A CB  1 
ATOM   685  C  CG  . LEU A 1 97  ? 140.239 199.180 183.486 1.00 10.12 ? 97   LEU A CG  1 
ATOM   686  C  CD1 . LEU A 1 97  ? 139.584 198.813 182.166 1.00 10.12 ? 97   LEU A CD1 1 
ATOM   687  C  CD2 . LEU A 1 97  ? 139.222 199.133 184.610 1.00 10.12 ? 97   LEU A CD2 1 
ATOM   688  N  N   . LEU A 1 98  ? 141.550 197.187 186.724 1.00 12.12 ? 98   LEU A N   1 
ATOM   689  C  CA  . LEU A 1 98  ? 140.779 196.915 187.932 1.00 12.12 ? 98   LEU A CA  1 
ATOM   690  C  C   . LEU A 1 98  ? 141.374 197.612 189.145 1.00 12.12 ? 98   LEU A C   1 
ATOM   691  O  O   . LEU A 1 98  ? 140.636 198.179 189.960 1.00 12.12 ? 98   LEU A O   1 
ATOM   692  C  CB  . LEU A 1 98  ? 140.695 195.407 188.176 1.00 12.12 ? 98   LEU A CB  1 
ATOM   693  C  CG  . LEU A 1 98  ? 139.747 194.626 187.260 1.00 12.12 ? 98   LEU A CG  1 
ATOM   694  C  CD1 . LEU A 1 98  ? 139.766 193.152 187.614 1.00 12.12 ? 98   LEU A CD1 1 
ATOM   695  C  CD2 . LEU A 1 98  ? 138.328 195.169 187.335 1.00 12.12 ? 98   LEU A CD2 1 
ATOM   696  N  N   . ASP A 1 99  ? 142.701 197.599 189.277 1.00 14.74 ? 99   ASP A N   1 
ATOM   697  C  CA  . ASP A 1 99  ? 143.329 198.260 190.415 1.00 14.74 ? 99   ASP A CA  1 
ATOM   698  C  C   . ASP A 1 99  ? 142.928 199.726 190.483 1.00 14.74 ? 99   ASP A C   1 
ATOM   699  O  O   . ASP A 1 99  ? 142.806 200.292 191.575 1.00 14.74 ? 99   ASP A O   1 
ATOM   700  C  CB  . ASP A 1 99  ? 144.848 198.128 190.328 1.00 14.74 ? 99   ASP A CB  1 
ATOM   701  C  CG  . ASP A 1 99  ? 145.393 198.594 189.000 1.00 14.74 ? 99   ASP A CG  1 
ATOM   702  O  OD1 . ASP A 1 99  ? 144.579 198.981 188.137 1.00 14.74 ? 99   ASP A OD1 1 
ATOM   703  O  OD2 . ASP A 1 99  ? 146.629 198.573 188.818 1.00 14.74 ? 99   ASP A OD2 1 
ATOM   704  N  N   . TYR A 1 100 ? 142.714 200.359 189.327 1.00 16.15 ? 100  TYR A N   1 
ATOM   705  C  CA  . TYR A 1 100 ? 142.333 201.767 189.336 1.00 16.15 ? 100  TYR A CA  1 
ATOM   706  C  C   . TYR A 1 100 ? 140.993 201.961 190.033 1.00 16.15 ? 100  TYR A C   1 
ATOM   707  O  O   . TYR A 1 100 ? 140.800 202.941 190.762 1.00 16.15 ? 100  TYR A O   1 
ATOM   708  C  CB  . TYR A 1 100 ? 142.290 202.315 187.908 1.00 16.15 ? 100  TYR A CB  1 
ATOM   709  C  CG  . TYR A 1 100 ? 141.553 203.629 187.778 1.00 16.15 ? 100  TYR A CG  1 
ATOM   710  C  CD1 . TYR A 1 100 ? 140.178 203.665 187.581 1.00 16.15 ? 100  TYR A CD1 1 
ATOM   711  C  CD2 . TYR A 1 100 ? 142.232 204.836 187.860 1.00 16.15 ? 100  TYR A CD2 1 
ATOM   712  C  CE1 . TYR A 1 100 ? 139.504 204.863 187.468 1.00 16.15 ? 100  TYR A CE1 1 
ATOM   713  C  CE2 . TYR A 1 100 ? 141.565 206.040 187.747 1.00 16.15 ? 100  TYR A CE2 1 
ATOM   714  C  CZ  . TYR A 1 100 ? 140.202 206.047 187.551 1.00 16.15 ? 100  TYR A CZ  1 
ATOM   715  O  OH  . TYR A 1 100 ? 139.534 207.244 187.438 1.00 16.15 ? 100  TYR A OH  1 
ATOM   716  N  N   . GLN A 1 101 ? 140.053 201.037 189.822 1.00 15.68 ? 101  GLN A N   1 
ATOM   717  C  CA  . GLN A 1 101 ? 138.757 201.138 190.481 1.00 15.68 ? 101  GLN A CA  1 
ATOM   718  C  C   . GLN A 1 101 ? 138.805 200.664 191.925 1.00 15.68 ? 101  GLN A C   1 
ATOM   719  O  O   . GLN A 1 101 ? 137.800 200.778 192.634 1.00 15.68 ? 101  GLN A O   1 
ATOM   720  C  CB  . GLN A 1 101 ? 137.708 200.330 189.715 1.00 15.68 ? 101  GLN A CB  1 
ATOM   721  C  CG  . GLN A 1 101 ? 137.089 201.067 188.543 1.00 15.68 ? 101  GLN A CG  1 
ATOM   722  C  CD  . GLN A 1 101 ? 137.771 200.748 187.234 1.00 15.68 ? 101  GLN A CD  1 
ATOM   723  O  OE1 . GLN A 1 101 ? 138.959 200.436 187.200 1.00 15.68 ? 101  GLN A OE1 1 
ATOM   724  N  NE2 . GLN A 1 101 ? 137.020 200.826 186.144 1.00 15.68 ? 101  GLN A NE2 1 
ATOM   725  N  N   . GLY A 1 102 ? 139.938 200.132 192.376 1.00 16.40 ? 102  GLY A N   1 
ATOM   726  C  CA  . GLY A 1 102 ? 140.005 199.568 193.706 1.00 16.40 ? 102  GLY A CA  1 
ATOM   727  C  C   . GLY A 1 102 ? 139.265 198.262 193.846 1.00 16.40 ? 102  GLY A C   1 
ATOM   728  O  O   . GLY A 1 102 ? 138.971 197.843 194.970 1.00 16.40 ? 102  GLY A O   1 
ATOM   729  N  N   . MET A 1 103 ? 138.944 197.607 192.729 1.00 15.04 ? 103  MET A N   1 
ATOM   730  C  CA  . MET A 1 103 ? 138.204 196.352 192.788 1.00 15.04 ? 103  MET A CA  1 
ATOM   731  C  C   . MET A 1 103 ? 139.072 195.227 193.339 1.00 15.04 ? 103  MET A C   1 
ATOM   732  O  O   . MET A 1 103 ? 138.572 194.131 193.609 1.00 15.04 ? 103  MET A O   1 
ATOM   733  C  CB  . MET A 1 103 ? 137.678 195.995 191.397 1.00 15.04 ? 103  MET A CB  1 
ATOM   734  C  CG  . MET A 1 103 ? 136.854 194.714 191.326 1.00 15.04 ? 103  MET A CG  1 
ATOM   735  S  SD  . MET A 1 103 ? 135.816 194.384 192.766 1.00 15.04 ? 103  MET A SD  1 
ATOM   736  C  CE  . MET A 1 103 ? 134.799 195.859 192.818 1.00 15.04 ? 103  MET A CE  1 
ATOM   737  N  N   . LEU A 1 104 ? 140.376 195.468 193.486 1.00 13.51 ? 104  LEU A N   1 
ATOM   738  C  CA  . LEU A 1 104 ? 141.280 194.502 194.099 1.00 13.51 ? 104  LEU A CA  1 
ATOM   739  C  C   . LEU A 1 104 ? 141.518 194.872 195.558 1.00 13.51 ? 104  LEU A C   1 
ATOM   740  O  O   . LEU A 1 104 ? 142.341 195.751 195.840 1.00 13.51 ? 104  LEU A O   1 
ATOM   741  C  CB  . LEU A 1 104 ? 142.616 194.458 193.356 1.00 13.51 ? 104  LEU A CB  1 
ATOM   742  C  CG  . LEU A 1 104 ? 142.590 194.371 191.831 1.00 13.51 ? 104  LEU A CG  1 
ATOM   743  C  CD1 . LEU A 1 104 ? 143.935 194.790 191.273 1.00 13.51 ? 104  LEU A CD1 1 
ATOM   744  C  CD2 . LEU A 1 104 ? 142.237 192.971 191.370 1.00 13.51 ? 104  LEU A CD2 1 
ATOM   745  N  N   . PRO A 1 105 ? 140.832 194.241 196.515 1.00 15.71 ? 105  PRO A N   1 
ATOM   746  C  CA  . PRO A 1 105 ? 141.109 194.557 197.922 1.00 15.71 ? 105  PRO A CA  1 
ATOM   747  C  C   . PRO A 1 105 ? 142.380 193.886 198.408 1.00 15.71 ? 105  PRO A C   1 
ATOM   748  O  O   . PRO A 1 105 ? 142.414 192.662 198.555 1.00 15.71 ? 105  PRO A O   1 
ATOM   749  C  CB  . PRO A 1 105 ? 139.884 194.021 198.675 1.00 15.71 ? 105  PRO A CB  1 
ATOM   750  C  CG  . PRO A 1 105 ? 139.092 193.234 197.710 1.00 15.71 ? 105  PRO A CG  1 
ATOM   751  C  CD  . PRO A 1 105 ? 139.668 193.357 196.344 1.00 15.71 ? 105  PRO A CD  1 
ATOM   752  N  N   . VAL A 1 106 ? 143.426 194.668 198.655 1.00 15.41 ? 106  VAL A N   1 
ATOM   753  C  CA  . VAL A 1 106 ? 144.686 194.165 199.191 1.00 15.41 ? 106  VAL A CA  1 
ATOM   754  C  C   . VAL A 1 106 ? 144.955 194.889 200.501 1.00 15.41 ? 106  VAL A C   1 
ATOM   755  O  O   . VAL A 1 106 ? 145.118 196.115 200.518 1.00 15.41 ? 106  VAL A O   1 
ATOM   756  C  CB  . VAL A 1 106 ? 145.844 194.370 198.205 1.00 15.41 ? 106  VAL A CB  1 
ATOM   757  C  CG1 . VAL A 1 106 ? 147.105 193.707 198.730 1.00 15.41 ? 106  VAL A CG1 1 
ATOM   758  C  CG2 . VAL A 1 106 ? 145.475 193.831 196.837 1.00 15.41 ? 106  VAL A CG2 1 
ATOM   759  N  N   . CYS A 1 107 ? 145.004 194.141 201.591 1.00 17.25 ? 107  CYS A N   1 
ATOM   760  C  CA  . CYS A 1 107 ? 145.272 194.751 202.882 1.00 17.25 ? 107  CYS A CA  1 
ATOM   761  C  C   . CYS A 1 107 ? 146.698 195.296 202.901 1.00 17.25 ? 107  CYS A C   1 
ATOM   762  O  O   . CYS A 1 107 ? 147.632 194.581 202.512 1.00 17.25 ? 107  CYS A O   1 
ATOM   763  C  CB  . CYS A 1 107 ? 145.077 193.737 204.007 1.00 17.25 ? 107  CYS A CB  1 
ATOM   764  S  SG  . CYS A 1 107 ? 143.418 193.031 204.098 1.00 17.25 ? 107  CYS A SG  1 
ATOM   765  N  N   . PRO A 1 108 ? 146.911 196.540 203.325 1.00 19.98 ? 108  PRO A N   1 
ATOM   766  C  CA  . PRO A 1 108 ? 148.276 197.073 203.382 1.00 19.98 ? 108  PRO A CA  1 
ATOM   767  C  C   . PRO A 1 108 ? 149.069 196.458 204.524 1.00 19.98 ? 108  PRO A C   1 
ATOM   768  O  O   . PRO A 1 108 ? 148.520 196.026 205.540 1.00 19.98 ? 108  PRO A O   1 
ATOM   769  C  CB  . PRO A 1 108 ? 148.061 198.572 203.601 1.00 19.98 ? 108  PRO A CB  1 
ATOM   770  C  CG  . PRO A 1 108 ? 146.777 198.644 204.350 1.00 19.98 ? 108  PRO A CG  1 
ATOM   771  C  CD  . PRO A 1 108 ? 145.928 197.499 203.859 1.00 19.98 ? 108  PRO A CD  1 
ATOM   772  N  N   . LEU A 1 109 ? 150.388 196.427 204.347 1.00 19.93 ? 109  LEU A N   1 
ATOM   773  C  CA  . LEU A 1 109 ? 151.258 195.885 205.383 1.00 19.93 ? 109  LEU A CA  1 
ATOM   774  C  C   . LEU A 1 109 ? 151.231 196.772 206.621 1.00 19.93 ? 109  LEU A C   1 
ATOM   775  O  O   . LEU A 1 109 ? 151.162 198.001 206.526 1.00 19.93 ? 109  LEU A O   1 
ATOM   776  C  CB  . LEU A 1 109 ? 152.691 195.748 204.866 1.00 19.93 ? 109  LEU A CB  1 
ATOM   777  C  CG  . LEU A 1 109 ? 152.922 194.678 203.797 1.00 19.93 ? 109  LEU A CG  1 
ATOM   778  C  CD1 . LEU A 1 109 ? 154.286 194.862 203.149 1.00 19.93 ? 109  LEU A CD1 1 
ATOM   779  C  CD2 . LEU A 1 109 ? 152.792 193.288 204.397 1.00 19.93 ? 109  LEU A CD2 1 
ATOM   780  N  N   . ILE A 1 110 ? 151.285 196.138 207.788 1.00 18.74 ? 110  ILE A N   1 
ATOM   781  C  CA  . ILE A 1 110 ? 151.228 196.856 209.053 1.00 18.74 ? 110  ILE A CA  1 
ATOM   782  C  C   . ILE A 1 110 ? 152.629 197.301 209.446 1.00 18.74 ? 110  ILE A C   1 
ATOM   783  O  O   . ILE A 1 110 ? 153.509 196.472 209.679 1.00 18.74 ? 110  ILE A O   1 
ATOM   784  C  CB  . ILE A 1 110 ? 150.598 195.997 210.169 1.00 18.74 ? 110  ILE A CB  1 
ATOM   785  C  CG1 . ILE A 1 110 ? 149.246 195.425 209.728 1.00 18.74 ? 110  ILE A CG1 1 
ATOM   786  C  CG2 . ILE A 1 110 ? 150.428 196.820 211.438 1.00 18.74 ? 110  ILE A CG2 1 
ATOM   787  C  CD1 . ILE A 1 110 ? 149.331 194.133 208.925 1.00 18.74 ? 110  ILE A CD1 1 
ATOM   788  N  N   . ILE A 1 150 ? 142.340 198.167 209.621 1.00 21.05 ? 150  ILE A N   1 
ATOM   789  C  CA  . ILE A 1 150 ? 142.990 199.134 208.748 1.00 21.05 ? 150  ILE A CA  1 
ATOM   790  C  C   . ILE A 1 150 ? 142.209 199.207 207.429 1.00 21.05 ? 150  ILE A C   1 
ATOM   791  O  O   . ILE A 1 150 ? 141.981 198.183 206.786 1.00 21.05 ? 150  ILE A O   1 
ATOM   792  C  CB  . ILE A 1 150 ? 144.478 198.766 208.527 1.00 21.05 ? 150  ILE A CB  1 
ATOM   793  C  CG1 . ILE A 1 150 ? 145.217 199.906 207.824 1.00 21.05 ? 150  ILE A CG1 1 
ATOM   794  C  CG2 . ILE A 1 150 ? 144.610 197.477 207.730 1.00 21.05 ? 150  ILE A CG2 1 
ATOM   795  C  CD1 . ILE A 1 150 ? 146.725 199.793 207.903 1.00 21.05 ? 150  ILE A CD1 1 
ATOM   796  N  N   . PRO A 1 151 ? 141.781 200.408 207.032 1.00 20.71 ? 151  PRO A N   1 
ATOM   797  C  CA  . PRO A 1 151 ? 140.924 200.522 205.846 1.00 20.71 ? 151  PRO A CA  1 
ATOM   798  C  C   . PRO A 1 151 ? 141.650 200.144 204.564 1.00 20.71 ? 151  PRO A C   1 
ATOM   799  O  O   . PRO A 1 151 ? 142.852 200.373 204.409 1.00 20.71 ? 151  PRO A O   1 
ATOM   800  C  CB  . PRO A 1 151 ? 140.523 202.002 205.842 1.00 20.71 ? 151  PRO A CB  1 
ATOM   801  C  CG  . PRO A 1 151 ? 141.628 202.686 206.537 1.00 20.71 ? 151  PRO A CG  1 
ATOM   802  C  CD  . PRO A 1 151 ? 142.105 201.731 207.595 1.00 20.71 ? 151  PRO A CD  1 
ATOM   803  N  N   . ILE A 1 152 ? 140.892 199.568 203.637 1.00 19.56 ? 152  ILE A N   1 
ATOM   804  C  CA  . ILE A 1 152 ? 141.460 199.167 202.347 1.00 19.56 ? 152  ILE A CA  1 
ATOM   805  C  C   . ILE A 1 152 ? 141.806 200.417 201.550 1.00 19.56 ? 152  ILE A C   1 
ATOM   806  O  O   . ILE A 1 152 ? 141.087 201.433 201.652 1.00 19.56 ? 152  ILE A O   1 
ATOM   807  C  CB  . ILE A 1 152 ? 140.466 198.277 201.579 1.00 19.56 ? 152  ILE A CB  1 
ATOM   808  C  CG1 . ILE A 1 152 ? 140.229 196.968 202.339 1.00 19.56 ? 152  ILE A CG1 1 
ATOM   809  C  CG2 . ILE A 1 152 ? 140.968 197.973 200.173 1.00 19.56 ? 152  ILE A CG2 1 
ATOM   810  C  CD1 . ILE A 1 152 ? 139.077 197.021 203.326 1.00 19.56 ? 152  ILE A CD1 1 
ATOM   811  N  N   . PRO A 1 153 ? 142.875 200.422 200.753 1.00 18.07 ? 153  PRO A N   1 
ATOM   812  C  CA  . PRO A 1 153 ? 143.158 201.600 199.923 1.00 18.07 ? 153  PRO A CA  1 
ATOM   813  C  C   . PRO A 1 153 ? 142.017 201.893 198.960 1.00 18.07 ? 153  PRO A C   1 
ATOM   814  O  O   . PRO A 1 153 ? 141.379 200.986 198.420 1.00 18.07 ? 153  PRO A O   1 
ATOM   815  C  CB  . PRO A 1 153 ? 144.439 201.218 199.172 1.00 18.07 ? 153  PRO A CB  1 
ATOM   816  C  CG  . PRO A 1 153 ? 145.036 200.090 199.928 1.00 18.07 ? 153  PRO A CG  1 
ATOM   817  C  CD  . PRO A 1 153 ? 143.964 199.430 200.727 1.00 18.07 ? 153  PRO A CD  1 
ATOM   818  N  N   . SER A 1 154 ? 141.763 203.186 198.749 1.00 18.15 ? 154  SER A N   1 
ATOM   819  C  CA  . SER A 1 154 ? 140.670 203.589 197.869 1.00 18.15 ? 154  SER A CA  1 
ATOM   820  C  C   . SER A 1 154 ? 140.939 203.182 196.425 1.00 18.15 ? 154  SER A C   1 
ATOM   821  O  O   . SER A 1 154 ? 140.031 202.723 195.722 1.00 18.15 ? 154  SER A O   1 
ATOM   822  C  CB  . SER A 1 154 ? 140.450 205.098 197.967 1.00 18.15 ? 154  SER A CB  1 
ATOM   823  O  OG  . SER A 1 154 ? 141.681 205.798 197.925 1.00 18.15 ? 154  SER A OG  1 
ATOM   824  N  N   . SER A 1 155 ? 142.177 203.347 195.963 1.00 16.28 ? 155  SER A N   1 
ATOM   825  C  CA  . SER A 1 155 ? 142.538 203.003 194.596 1.00 16.28 ? 155  SER A CA  1 
ATOM   826  C  C   . SER A 1 155 ? 143.991 202.558 194.566 1.00 16.28 ? 155  SER A C   1 
ATOM   827  O  O   . SER A 1 155 ? 144.780 202.885 195.456 1.00 16.28 ? 155  SER A O   1 
ATOM   828  C  CB  . SER A 1 155 ? 142.321 204.183 193.643 1.00 16.28 ? 155  SER A CB  1 
ATOM   829  O  OG  . SER A 1 155 ? 142.735 203.856 192.328 1.00 16.28 ? 155  SER A OG  1 
ATOM   830  N  N   . TRP A 1 156 ? 144.337 201.802 193.525 1.00 15.68 ? 156  TRP A N   1 
ATOM   831  C  CA  . TRP A 1 156 ? 145.686 201.260 193.375 1.00 15.68 ? 156  TRP A CA  1 
ATOM   832  C  C   . TRP A 1 156 ? 146.114 200.506 194.630 1.00 15.68 ? 156  TRP A C   1 
ATOM   833  O  O   . TRP A 1 156 ? 147.274 200.551 195.046 1.00 15.68 ? 156  TRP A O   1 
ATOM   834  C  CB  . TRP A 1 156 ? 146.688 202.365 193.041 1.00 15.68 ? 156  TRP A CB  1 
ATOM   835  C  CG  . TRP A 1 156 ? 146.486 202.975 191.693 1.00 15.68 ? 156  TRP A CG  1 
ATOM   836  C  CD1 . TRP A 1 156 ? 145.755 204.088 191.396 1.00 15.68 ? 156  TRP A CD1 1 
ATOM   837  C  CD2 . TRP A 1 156 ? 147.030 202.509 190.455 1.00 15.68 ? 156  TRP A CD2 1 
ATOM   838  N  NE1 . TRP A 1 156 ? 145.809 204.342 190.047 1.00 15.68 ? 156  TRP A NE1 1 
ATOM   839  C  CE2 . TRP A 1 156 ? 146.587 203.387 189.448 1.00 15.68 ? 156  TRP A CE2 1 
ATOM   840  C  CE3 . TRP A 1 156 ? 147.849 201.435 190.101 1.00 15.68 ? 156  TRP A CE3 1 
ATOM   841  C  CZ2 . TRP A 1 156 ? 146.934 203.222 188.112 1.00 15.68 ? 156  TRP A CZ2 1 
ATOM   842  C  CZ3 . TRP A 1 156 ? 148.192 201.273 188.775 1.00 15.68 ? 156  TRP A CZ3 1 
ATOM   843  C  CH2 . TRP A 1 156 ? 147.735 202.161 187.796 1.00 15.68 ? 156  TRP A CH2 1 
ATOM   844  N  N   . ALA A 1 157 ? 145.163 199.804 195.246 1.00 15.79 ? 157  ALA A N   1 
ATOM   845  C  CA  . ALA A 1 157 ? 145.480 199.038 196.445 1.00 15.79 ? 157  ALA A CA  1 
ATOM   846  C  C   . ALA A 1 157 ? 146.507 197.956 196.141 1.00 15.79 ? 157  ALA A C   1 
ATOM   847  O  O   . ALA A 1 157 ? 147.475 197.773 196.891 1.00 15.79 ? 157  ALA A O   1 
ATOM   848  C  CB  . ALA A 1 157 ? 144.206 198.424 197.024 1.00 15.79 ? 157  ALA A CB  1 
ATOM   849  N  N   . PHE A 1 158 ? 146.314 197.229 195.040 1.00 13.53 ? 158  PHE A N   1 
ATOM   850  C  CA  . PHE A 1 158 ? 147.248 196.171 194.675 1.00 13.53 ? 158  PHE A CA  1 
ATOM   851  C  C   . PHE A 1 158 ? 148.629 196.742 194.380 1.00 13.53 ? 158  PHE A C   1 
ATOM   852  O  O   . PHE A 1 158 ? 149.648 196.213 194.841 1.00 13.53 ? 158  PHE A O   1 
ATOM   853  C  CB  . PHE A 1 158 ? 146.711 195.405 193.467 1.00 13.53 ? 158  PHE A CB  1 
ATOM   854  C  CG  . PHE A 1 158 ? 147.521 194.198 193.103 1.00 13.53 ? 158  PHE A CG  1 
ATOM   855  C  CD1 . PHE A 1 158 ? 147.673 193.156 193.995 1.00 13.53 ? 158  PHE A CD1 1 
ATOM   856  C  CD2 . PHE A 1 158 ? 148.118 194.101 191.860 1.00 13.53 ? 158  PHE A CD2 1 
ATOM   857  C  CE1 . PHE A 1 158 ? 148.411 192.046 193.659 1.00 13.53 ? 158  PHE A CE1 1 
ATOM   858  C  CE2 . PHE A 1 158 ? 148.856 192.990 191.519 1.00 13.53 ? 158  PHE A CE2 1 
ATOM   859  C  CZ  . PHE A 1 158 ? 149.002 191.962 192.420 1.00 13.53 ? 158  PHE A CZ  1 
ATOM   860  N  N   . GLY A 1 159 ? 148.679 197.827 193.609 1.00 14.52 ? 159  GLY A N   1 
ATOM   861  C  CA  . GLY A 1 159 ? 149.957 198.460 193.337 1.00 14.52 ? 159  GLY A CA  1 
ATOM   862  C  C   . GLY A 1 159 ? 150.632 198.952 194.601 1.00 14.52 ? 159  GLY A C   1 
ATOM   863  O  O   . GLY A 1 159 ? 151.841 198.782 194.778 1.00 14.52 ? 159  GLY A O   1 
ATOM   864  N  N   . LYS A 1 160 ? 149.860 199.570 195.498 1.00 15.75 ? 160  LYS A N   1 
ATOM   865  C  CA  . LYS A 1 160 ? 150.434 200.039 196.753 1.00 15.75 ? 160  LYS A CA  1 
ATOM   866  C  C   . LYS A 1 160 ? 151.023 198.886 197.550 1.00 15.75 ? 160  LYS A C   1 
ATOM   867  O  O   . LYS A 1 160 ? 152.150 198.982 198.046 1.00 15.75 ? 160  LYS A O   1 
ATOM   868  C  CB  . LYS A 1 160 ? 149.384 200.769 197.588 1.00 15.75 ? 160  LYS A CB  1 
ATOM   869  C  CG  . LYS A 1 160 ? 149.153 202.214 197.189 1.00 15.75 ? 160  LYS A CG  1 
ATOM   870  C  CD  . LYS A 1 160 ? 147.979 202.806 197.951 1.00 15.75 ? 160  LYS A CD  1 
ATOM   871  C  CE  . LYS A 1 160 ? 148.317 203.009 199.421 1.00 15.75 ? 160  LYS A CE  1 
ATOM   872  N  NZ  . LYS A 1 160 ? 147.201 203.636 200.179 1.00 15.75 ? 160  LYS A NZ  1 
ATOM   873  N  N   . PHE A 1 161 ? 150.275 197.791 197.694 1.00 15.96 ? 161  PHE A N   1 
ATOM   874  C  CA  . PHE A 1 161 ? 150.790 196.668 198.469 1.00 15.96 ? 161  PHE A CA  1 
ATOM   875  C  C   . PHE A 1 161 ? 152.054 196.107 197.837 1.00 15.96 ? 161  PHE A C   1 
ATOM   876  O  O   . PHE A 1 161 ? 153.045 195.851 198.531 1.00 15.96 ? 161  PHE A O   1 
ATOM   877  C  CB  . PHE A 1 161 ? 149.744 195.564 198.591 1.00 15.96 ? 161  PHE A CB  1 
ATOM   878  C  CG  . PHE A 1 161 ? 150.334 194.222 198.923 1.00 15.96 ? 161  PHE A CG  1 
ATOM   879  C  CD1 . PHE A 1 161 ? 150.705 193.919 200.220 1.00 15.96 ? 161  PHE A CD1 1 
ATOM   880  C  CD2 . PHE A 1 161 ? 150.543 193.276 197.935 1.00 15.96 ? 161  PHE A CD2 1 
ATOM   881  C  CE1 . PHE A 1 161 ? 151.257 192.693 200.528 1.00 15.96 ? 161  PHE A CE1 1 
ATOM   882  C  CE2 . PHE A 1 161 ? 151.096 192.048 198.238 1.00 15.96 ? 161  PHE A CE2 1 
ATOM   883  C  CZ  . PHE A 1 161 ? 151.453 191.757 199.535 1.00 15.96 ? 161  PHE A CZ  1 
ATOM   884  N  N   . LEU A 1 162 ? 152.036 195.897 196.519 1.00 14.86 ? 162  LEU A N   1 
ATOM   885  C  CA  . LEU A 1 162 ? 153.211 195.338 195.865 1.00 14.86 ? 162  LEU A CA  1 
ATOM   886  C  C   . LEU A 1 162 ? 154.423 196.238 196.046 1.00 14.86 ? 162  LEU A C   1 
ATOM   887  O  O   . LEU A 1 162 ? 155.508 195.758 196.393 1.00 14.86 ? 162  LEU A O   1 
ATOM   888  C  CB  . LEU A 1 162 ? 152.941 195.110 194.380 1.00 14.86 ? 162  LEU A CB  1 
ATOM   889  C  CG  . LEU A 1 162 ? 152.030 193.940 194.017 1.00 14.86 ? 162  LEU A CG  1 
ATOM   890  C  CD1 . LEU A 1 162 ? 151.819 193.897 192.515 1.00 14.86 ? 162  LEU A CD1 1 
ATOM   891  C  CD2 . LEU A 1 162 ? 152.621 192.631 194.514 1.00 14.86 ? 162  LEU A CD2 1 
ATOM   892  N  N   . TRP A 1 163 ? 154.267 197.546 195.823 1.00 17.32 ? 163  TRP A N   1 
ATOM   893  C  CA  . TRP A 1 163 ? 155.422 198.427 195.936 1.00 17.32 ? 163  TRP A CA  1 
ATOM   894  C  C   . TRP A 1 163 ? 155.917 198.508 197.372 1.00 17.32 ? 163  TRP A C   1 
ATOM   895  O  O   . TRP A 1 163 ? 157.128 198.502 197.615 1.00 17.32 ? 163  TRP A O   1 
ATOM   896  C  CB  . TRP A 1 163 ? 155.104 199.826 195.418 1.00 17.32 ? 163  TRP A CB  1 
ATOM   897  C  CG  . TRP A 1 163 ? 156.292 200.717 195.560 1.00 17.32 ? 163  TRP A CG  1 
ATOM   898  C  CD1 . TRP A 1 163 ? 156.439 201.764 196.421 1.00 17.32 ? 163  TRP A CD1 1 
ATOM   899  C  CD2 . TRP A 1 163 ? 157.529 200.607 194.847 1.00 17.32 ? 163  TRP A CD2 1 
ATOM   900  N  NE1 . TRP A 1 163 ? 157.685 202.325 196.274 1.00 17.32 ? 163  TRP A NE1 1 
ATOM   901  C  CE2 . TRP A 1 163 ? 158.373 201.631 195.314 1.00 17.32 ? 163  TRP A CE2 1 
ATOM   902  C  CE3 . TRP A 1 163 ? 158.000 199.746 193.851 1.00 17.32 ? 163  TRP A CE3 1 
ATOM   903  C  CZ2 . TRP A 1 163 ? 159.660 201.820 194.818 1.00 17.32 ? 163  TRP A CZ2 1 
ATOM   904  C  CZ3 . TRP A 1 163 ? 159.276 199.936 193.360 1.00 17.32 ? 163  TRP A CZ3 1 
ATOM   905  C  CH2 . TRP A 1 163 ? 160.092 200.963 193.844 1.00 17.32 ? 163  TRP A CH2 1 
ATOM   906  N  N   . GLU A 1 164 ? 155.003 198.605 198.340 1.00 17.79 ? 164  GLU A N   1 
ATOM   907  C  CA  . GLU A 1 164 ? 155.433 198.677 199.731 1.00 17.79 ? 164  GLU A CA  1 
ATOM   908  C  C   . GLU A 1 164 ? 156.183 197.415 200.127 1.00 17.79 ? 164  GLU A C   1 
ATOM   909  O  O   . GLU A 1 164 ? 157.239 197.487 200.765 1.00 17.79 ? 164  GLU A O   1 
ATOM   910  C  CB  . GLU A 1 164 ? 154.229 198.898 200.646 1.00 17.79 ? 164  GLU A CB  1 
ATOM   911  C  CG  . GLU A 1 164 ? 154.607 199.276 202.074 1.00 17.79 ? 164  GLU A CG  1 
ATOM   912  C  CD  . GLU A 1 164 ? 153.533 198.927 203.087 1.00 17.79 ? 164  GLU A CD  1 
ATOM   913  O  OE1 . GLU A 1 164 ? 152.561 198.234 202.721 1.00 17.79 ? 164  GLU A OE1 1 
ATOM   914  O  OE2 . GLU A 1 164 ? 153.662 199.346 204.257 1.00 17.79 ? 164  GLU A OE2 1 
ATOM   915  N  N   . TRP A 1 165 ? 155.666 196.248 199.738 1.00 17.16 ? 165  TRP A N   1 
ATOM   916  C  CA  . TRP A 1 165 ? 156.349 195.001 200.058 1.00 17.16 ? 165  TRP A CA  1 
ATOM   917  C  C   . TRP A 1 165 ? 157.717 194.932 199.389 1.00 17.16 ? 165  TRP A C   1 
ATOM   918  O  O   . TRP A 1 165 ? 158.709 194.550 200.023 1.00 17.16 ? 165  TRP A O   1 
ATOM   919  C  CB  . TRP A 1 165 ? 155.479 193.817 199.638 1.00 17.16 ? 165  TRP A CB  1 
ATOM   920  C  CG  . TRP A 1 165 ? 156.171 192.503 199.723 1.00 17.16 ? 165  TRP A CG  1 
ATOM   921  C  CD1 . TRP A 1 165 ? 156.259 191.692 200.814 1.00 17.16 ? 165  TRP A CD1 1 
ATOM   922  C  CD2 . TRP A 1 165 ? 156.873 191.839 198.670 1.00 17.16 ? 165  TRP A CD2 1 
ATOM   923  N  NE1 . TRP A 1 165 ? 156.976 190.563 200.506 1.00 17.16 ? 165  TRP A NE1 1 
ATOM   924  C  CE2 . TRP A 1 165 ? 157.364 190.630 199.194 1.00 17.16 ? 165  TRP A CE2 1 
ATOM   925  C  CE3 . TRP A 1 165 ? 157.135 192.151 197.334 1.00 17.16 ? 165  TRP A CE3 1 
ATOM   926  C  CZ2 . TRP A 1 165 ? 158.103 189.734 198.430 1.00 17.16 ? 165  TRP A CZ2 1 
ATOM   927  C  CZ3 . TRP A 1 165 ? 157.866 191.260 196.577 1.00 17.16 ? 165  TRP A CZ3 1 
ATOM   928  C  CH2 . TRP A 1 165 ? 158.342 190.066 197.126 1.00 17.16 ? 165  TRP A CH2 1 
ATOM   929  N  N   . ALA A 1 166 ? 157.794 195.305 198.110 1.00 18.09 ? 166  ALA A N   1 
ATOM   930  C  CA  . ALA A 1 166 ? 159.068 195.250 197.403 1.00 18.09 ? 166  ALA A CA  1 
ATOM   931  C  C   . ALA A 1 166 ? 160.089 196.176 198.050 1.00 18.09 ? 166  ALA A C   1 
ATOM   932  O  O   . ALA A 1 166 ? 161.245 195.795 198.265 1.00 18.09 ? 166  ALA A O   1 
ATOM   933  C  CB  . ALA A 1 166 ? 158.864 195.613 195.933 1.00 18.09 ? 166  ALA A CB  1 
ATOM   934  N  N   . SER A 1 167 ? 159.671 197.400 198.382 1.00 22.48 ? 167  SER A N   1 
ATOM   935  C  CA  . SER A 1 167 ? 160.572 198.338 199.040 1.00 22.48 ? 167  SER A CA  1 
ATOM   936  C  C   . SER A 1 167 ? 161.014 197.807 200.394 1.00 22.48 ? 167  SER A C   1 
ATOM   937  O  O   . SER A 1 167 ? 162.178 197.966 200.782 1.00 22.48 ? 167  SER A O   1 
ATOM   938  C  CB  . SER A 1 167 ? 159.888 199.695 199.197 1.00 22.48 ? 167  SER A CB  1 
ATOM   939  O  OG  . SER A 1 167 ? 158.822 199.620 200.128 1.00 22.48 ? 167  SER A OG  1 
ATOM   940  N  N   . ALA A 1 168 ? 160.100 197.174 201.130 1.00 22.19 ? 168  ALA A N   1 
ATOM   941  C  CA  . ALA A 1 168 ? 160.468 196.585 202.410 1.00 22.19 ? 168  ALA A CA  1 
ATOM   942  C  C   . ALA A 1 168 ? 161.538 195.517 202.225 1.00 22.19 ? 168  ALA A C   1 
ATOM   943  O  O   . ALA A 1 168 ? 162.516 195.464 202.979 1.00 22.19 ? 168  ALA A O   1 
ATOM   944  C  CB  . ALA A 1 168 ? 159.231 195.996 203.087 1.00 22.19 ? 168  ALA A CB  1 
ATOM   945  N  N   . ARG A 1 169 ? 161.376 194.665 201.209 1.00 23.12 ? 169  ARG A N   1 
ATOM   946  C  CA  . ARG A 1 169 ? 162.290 193.539 201.037 1.00 23.12 ? 169  ARG A CA  1 
ATOM   947  C  C   . ARG A 1 169 ? 163.711 194.015 200.754 1.00 23.12 ? 169  ARG A C   1 
ATOM   948  O  O   . ARG A 1 169 ? 164.677 193.497 201.325 1.00 23.12 ? 169  ARG A O   1 
ATOM   949  C  CB  . ARG A 1 169 ? 161.798 192.632 199.908 1.00 23.12 ? 169  ARG A CB  1 
ATOM   950  C  CG  . ARG A 1 169 ? 160.597 191.711 200.215 1.00 23.12 ? 169  ARG A CG  1 
ATOM   951  C  CD  . ARG A 1 169 ? 160.848 190.550 201.206 1.00 23.12 ? 169  ARG A CD  1 
ATOM   952  N  NE  . ARG A 1 169 ? 161.465 190.916 202.476 1.00 23.12 ? 169  ARG A NE  1 
ATOM   953  C  CZ  . ARG A 1 169 ? 160.932 191.750 203.362 1.00 23.12 ? 169  ARG A CZ  1 
ATOM   954  N  NH1 . ARG A 1 169 ? 159.748 192.308 203.166 1.00 23.12 ? 169  ARG A NH1 1 
ATOM   955  N  NH2 . ARG A 1 169 ? 161.608 192.036 204.471 1.00 23.12 ? 169  ARG A NH2 1 
ATOM   956  N  N   . PHE A 1 170 ? 163.857 195.001 199.873 1.00 34.63 ? 170  PHE A N   1 
ATOM   957  C  CA  . PHE A 1 170 ? 165.162 195.505 199.460 1.00 34.63 ? 170  PHE A CA  1 
ATOM   958  C  C   . PHE A 1 170 ? 165.333 196.922 199.985 1.00 34.63 ? 170  PHE A C   1 
ATOM   959  O  O   . PHE A 1 170 ? 164.629 197.839 199.547 1.00 34.63 ? 170  PHE A O   1 
ATOM   960  C  CB  . PHE A 1 170 ? 165.300 195.478 197.936 1.00 34.63 ? 170  PHE A CB  1 
ATOM   961  N  N   . SER A 1 171 ? 166.266 197.100 200.923 1.00 41.73 ? 171  SER A N   1 
ATOM   962  C  CA  . SER A 1 171 ? 166.527 198.432 201.459 1.00 41.73 ? 171  SER A CA  1 
ATOM   963  C  C   . SER A 1 171 ? 167.366 199.265 200.498 1.00 41.73 ? 171  SER A C   1 
ATOM   964  O  O   . SER A 1 171 ? 167.125 200.467 200.341 1.00 41.73 ? 171  SER A O   1 
ATOM   965  C  CB  . SER A 1 171 ? 167.224 198.324 202.815 1.00 41.73 ? 171  SER A CB  1 
ATOM   966  N  N   . TRP A 1 172 ? 168.350 198.643 199.844 1.00 47.19 ? 172  TRP A N   1 
ATOM   967  C  CA  . TRP A 1 172 ? 169.229 199.381 198.945 1.00 47.19 ? 172  TRP A CA  1 
ATOM   968  C  C   . TRP A 1 172 ? 168.486 199.931 197.737 1.00 47.19 ? 172  TRP A C   1 
ATOM   969  O  O   . TRP A 1 172 ? 168.905 200.950 197.177 1.00 47.19 ? 172  TRP A O   1 
ATOM   970  C  CB  . TRP A 1 172 ? 170.376 198.482 198.481 1.00 47.19 ? 172  TRP A CB  1 
ATOM   971  N  N   . LEU A 1 173 ? 167.391 199.288 197.327 1.00 49.52 ? 173  LEU A N   1 
ATOM   972  C  CA  . LEU A 1 173 ? 166.678 199.729 196.133 1.00 49.52 ? 173  LEU A CA  1 
ATOM   973  C  C   . LEU A 1 173 ? 166.247 201.184 196.262 1.00 49.52 ? 173  LEU A C   1 
ATOM   974  O  O   . LEU A 1 173 ? 166.461 201.991 195.349 1.00 49.52 ? 173  LEU A O   1 
ATOM   975  C  CB  . LEU A 1 173 ? 165.467 198.828 195.888 1.00 49.52 ? 173  LEU A CB  1 
ATOM   976  N  N   . SER A 1 174 ? 165.660 201.544 197.405 1.00 56.16 ? 174  SER A N   1 
ATOM   977  C  CA  . SER A 1 174 ? 165.193 202.913 197.594 1.00 56.16 ? 174  SER A CA  1 
ATOM   978  C  C   . SER A 1 174 ? 166.325 203.917 197.428 1.00 56.16 ? 174  SER A C   1 
ATOM   979  O  O   . SER A 1 174 ? 166.078 205.081 197.094 1.00 56.16 ? 174  SER A O   1 
ATOM   980  C  CB  . SER A 1 174 ? 164.550 203.062 198.973 1.00 56.16 ? 174  SER A CB  1 
ATOM   981  N  N   . LEU A 1 175 ? 167.571 203.487 197.651 1.00 57.16 ? 175  LEU A N   1 
ATOM   982  C  CA  . LEU A 1 175 ? 168.701 204.396 197.500 1.00 57.16 ? 175  LEU A CA  1 
ATOM   983  C  C   . LEU A 1 175 ? 168.767 204.981 196.096 1.00 57.16 ? 175  LEU A C   1 
ATOM   984  O  O   . LEU A 1 175 ? 169.222 206.117 195.918 1.00 57.16 ? 175  LEU A O   1 
ATOM   985  C  CB  . LEU A 1 175 ? 170.005 203.669 197.831 1.00 57.16 ? 175  LEU A CB  1 
ATOM   986  N  N   . LEU A 1 176 ? 168.323 204.228 195.088 1.00 55.72 ? 176  LEU A N   1 
ATOM   987  C  CA  . LEU A 1 176 ? 168.343 204.727 193.719 1.00 55.72 ? 176  LEU A CA  1 
ATOM   988  C  C   . LEU A 1 176 ? 167.127 205.581 193.384 1.00 55.72 ? 176  LEU A C   1 
ATOM   989  O  O   . LEU A 1 176 ? 167.130 206.256 192.349 1.00 55.72 ? 176  LEU A O   1 
ATOM   990  C  CB  . LEU A 1 176 ? 168.430 203.559 192.735 1.00 55.72 ? 176  LEU A CB  1 
ATOM   991  N  N   . VAL A 1 177 ? 166.092 205.567 194.227 1.00 57.96 ? 177  VAL A N   1 
ATOM   992  C  CA  . VAL A 1 177 ? 164.875 206.322 193.920 1.00 57.96 ? 177  VAL A CA  1 
ATOM   993  C  C   . VAL A 1 177 ? 165.139 207.821 193.845 1.00 57.96 ? 177  VAL A C   1 
ATOM   994  O  O   . VAL A 1 177 ? 164.712 208.453 192.865 1.00 57.96 ? 177  VAL A O   1 
ATOM   995  C  CB  . VAL A 1 177 ? 163.771 205.974 194.934 1.00 57.96 ? 177  VAL A CB  1 
ATOM   996  N  N   . PRO A 1 178 ? 165.812 208.449 194.815 1.00 59.73 ? 178  PRO A N   1 
ATOM   997  C  CA  . PRO A 1 178 ? 165.974 209.915 194.748 1.00 59.73 ? 178  PRO A CA  1 
ATOM   998  C  C   . PRO A 1 178 ? 166.642 210.397 193.472 1.00 59.73 ? 178  PRO A C   1 
ATOM   999  O  O   . PRO A 1 178 ? 166.143 211.331 192.831 1.00 59.73 ? 178  PRO A O   1 
ATOM   1000 C  CB  . PRO A 1 178 ? 166.820 210.224 195.991 1.00 59.73 ? 178  PRO A CB  1 
ATOM   1001 C  CG  . PRO A 1 178 ? 166.552 209.100 196.929 1.00 59.73 ? 178  PRO A CG  1 
ATOM   1002 C  CD  . PRO A 1 178 ? 166.322 207.889 196.078 1.00 59.73 ? 178  PRO A CD  1 
ATOM   1003 N  N   . PHE A 1 179 ? 167.760 209.781 193.078 1.00 57.26 ? 179  PHE A N   1 
ATOM   1004 C  CA  . PHE A 1 179 ? 168.465 210.233 191.883 1.00 57.26 ? 179  PHE A CA  1 
ATOM   1005 C  C   . PHE A 1 179 ? 167.545 210.229 190.671 1.00 57.26 ? 179  PHE A C   1 
ATOM   1006 O  O   . PHE A 1 179 ? 167.573 211.160 189.857 1.00 57.26 ? 179  PHE A O   1 
ATOM   1007 C  CB  . PHE A 1 179 ? 169.690 209.352 191.626 1.00 57.26 ? 179  PHE A CB  1 
ATOM   1008 C  CG  . PHE A 1 179 ? 170.807 209.535 192.625 1.00 57.26 ? 179  PHE A CG  1 
ATOM   1009 C  CD1 . PHE A 1 179 ? 170.891 210.674 193.413 1.00 57.26 ? 179  PHE A CD1 1 
ATOM   1010 C  CD2 . PHE A 1 179 ? 171.779 208.558 192.770 1.00 57.26 ? 179  PHE A CD2 1 
ATOM   1011 C  CE1 . PHE A 1 179 ? 171.920 210.831 194.323 1.00 57.26 ? 179  PHE A CE1 1 
ATOM   1012 C  CE2 . PHE A 1 179 ? 172.809 208.711 193.679 1.00 57.26 ? 179  PHE A CE2 1 
ATOM   1013 C  CZ  . PHE A 1 179 ? 172.879 209.848 194.456 1.00 57.26 ? 179  PHE A CZ  1 
ATOM   1014 N  N   . VAL A 1 180 ? 166.710 209.197 190.540 1.00 60.80 ? 180  VAL A N   1 
ATOM   1015 C  CA  . VAL A 1 180 ? 165.756 209.155 189.436 1.00 60.80 ? 180  VAL A CA  1 
ATOM   1016 C  C   . VAL A 1 180 ? 164.897 210.413 189.443 1.00 60.80 ? 180  VAL A C   1 
ATOM   1017 O  O   . VAL A 1 180 ? 164.737 211.085 188.417 1.00 60.80 ? 180  VAL A O   1 
ATOM   1018 C  CB  . VAL A 1 180 ? 164.893 207.883 189.522 1.00 60.80 ? 180  VAL A CB  1 
ATOM   1019 N  N   . GLN A 1 181 ? 164.357 210.767 190.611 1.00 51.13 ? 181  GLN A N   1 
ATOM   1020 C  CA  . GLN A 1 181 ? 163.600 212.008 190.721 1.00 51.13 ? 181  GLN A CA  1 
ATOM   1021 C  C   . GLN A 1 181 ? 164.463 213.201 190.336 1.00 51.13 ? 181  GLN A C   1 
ATOM   1022 O  O   . GLN A 1 181 ? 164.004 214.108 189.631 1.00 51.13 ? 181  GLN A O   1 
ATOM   1023 C  CB  . GLN A 1 181 ? 163.062 212.170 192.142 1.00 51.13 ? 181  GLN A CB  1 
ATOM   1024 N  N   . TRP A 1 182 ? 165.723 213.212 190.779 1.00 53.13 ? 182  TRP A N   1 
ATOM   1025 C  CA  . TRP A 1 182 ? 166.633 214.274 190.365 1.00 53.13 ? 182  TRP A CA  1 
ATOM   1026 C  C   . TRP A 1 182 ? 166.787 214.291 188.851 1.00 53.13 ? 182  TRP A C   1 
ATOM   1027 O  O   . TRP A 1 182 ? 166.855 215.364 188.239 1.00 53.13 ? 182  TRP A O   1 
ATOM   1028 C  CB  . TRP A 1 182 ? 167.994 214.102 191.038 1.00 53.13 ? 182  TRP A CB  1 
ATOM   1029 C  CG  . TRP A 1 182 ? 168.930 215.232 190.752 1.00 53.13 ? 182  TRP A CG  1 
ATOM   1030 C  CD1 . TRP A 1 182 ? 168.785 216.533 191.139 1.00 53.13 ? 182  TRP A CD1 1 
ATOM   1031 C  CD2 . TRP A 1 182 ? 170.151 215.169 190.007 1.00 53.13 ? 182  TRP A CD2 1 
ATOM   1032 N  NE1 . TRP A 1 182 ? 169.842 217.282 190.685 1.00 53.13 ? 182  TRP A NE1 1 
ATOM   1033 C  CE2 . TRP A 1 182 ? 170.695 216.469 189.987 1.00 53.13 ? 182  TRP A CE2 1 
ATOM   1034 C  CE3 . TRP A 1 182 ? 170.838 214.139 189.358 1.00 53.13 ? 182  TRP A CE3 1 
ATOM   1035 C  CZ2 . TRP A 1 182 ? 171.895 216.766 189.344 1.00 53.13 ? 182  TRP A CZ2 1 
ATOM   1036 C  CZ3 . TRP A 1 182 ? 172.029 214.437 188.719 1.00 53.13 ? 182  TRP A CZ3 1 
ATOM   1037 C  CH2 . TRP A 1 182 ? 172.545 215.739 188.717 1.00 53.13 ? 182  TRP A CH2 1 
ATOM   1038 N  N   . PHE A 1 183 ? 166.833 213.112 188.228 1.00 52.72 ? 183  PHE A N   1 
ATOM   1039 C  CA  . PHE A 1 183 ? 166.849 213.060 186.772 1.00 52.72 ? 183  PHE A CA  1 
ATOM   1040 C  C   . PHE A 1 183 ? 165.619 213.752 186.199 1.00 52.72 ? 183  PHE A C   1 
ATOM   1041 O  O   . PHE A 1 183 ? 165.712 214.487 185.209 1.00 52.72 ? 183  PHE A O   1 
ATOM   1042 C  CB  . PHE A 1 183 ? 166.925 211.609 186.299 1.00 52.72 ? 183  PHE A CB  1 
ATOM   1043 N  N   . VAL A 1 184 ? 164.455 213.528 186.810 1.00 50.83 ? 184  VAL A N   1 
ATOM   1044 C  CA  . VAL A 1 184 ? 163.272 214.302 186.450 1.00 50.83 ? 184  VAL A CA  1 
ATOM   1045 C  C   . VAL A 1 184 ? 163.446 215.753 186.878 1.00 50.83 ? 184  VAL A C   1 
ATOM   1046 O  O   . VAL A 1 184 ? 163.080 216.681 186.148 1.00 50.83 ? 184  VAL A O   1 
ATOM   1047 C  CB  . VAL A 1 184 ? 162.013 213.674 187.075 1.00 50.83 ? 184  VAL A CB  1 
ATOM   1048 N  N   . GLY A 1 185 ? 164.011 215.971 188.070 1.00 52.40 ? 185  GLY A N   1 
ATOM   1049 C  CA  . GLY A 1 185 ? 164.202 217.321 188.568 1.00 52.40 ? 185  GLY A CA  1 
ATOM   1050 C  C   . GLY A 1 185 ? 165.250 218.115 187.823 1.00 52.40 ? 185  GLY A C   1 
ATOM   1051 O  O   . GLY A 1 185 ? 165.194 219.349 187.827 1.00 52.40 ? 185  GLY A O   1 
ATOM   1052 N  N   . LEU A 1 186 ? 166.203 217.439 187.187 1.00 39.95 ? 186  LEU A N   1 
ATOM   1053 C  CA  . LEU A 1 186 ? 167.159 218.125 186.338 1.00 39.95 ? 186  LEU A CA  1 
ATOM   1054 C  C   . LEU A 1 186 ? 166.446 218.693 185.112 1.00 39.95 ? 186  LEU A C   1 
ATOM   1055 O  O   . LEU A 1 186 ? 165.255 218.463 184.887 1.00 39.95 ? 186  LEU A O   1 
ATOM   1056 C  CB  . LEU A 1 186 ? 168.277 217.174 185.914 1.00 39.95 ? 186  LEU A CB  1 
ATOM   1057 N  N   . SER A 1 187 ? 167.191 219.445 184.314 1.00 22.53 ? 187  SER A N   1 
ATOM   1058 C  CA  . SER A 1 187 ? 166.626 220.048 183.120 1.00 22.53 ? 187  SER A CA  1 
ATOM   1059 C  C   . SER A 1 187 ? 166.094 218.955 182.193 1.00 22.53 ? 187  SER A C   1 
ATOM   1060 O  O   . SER A 1 187 ? 166.846 218.032 181.844 1.00 22.53 ? 187  SER A O   1 
ATOM   1061 C  CB  . SER A 1 187 ? 167.679 220.885 182.397 1.00 22.53 ? 187  SER A CB  1 
ATOM   1062 O  OG  . SER A 1 187 ? 167.783 222.177 182.969 1.00 22.53 ? 187  SER A OG  1 
ATOM   1063 N  N   . PRO A 1 188 ? 164.821 219.007 181.787 1.00 18.01 ? 188  PRO A N   1 
ATOM   1064 C  CA  . PRO A 1 188 ? 164.339 217.998 180.828 1.00 18.01 ? 188  PRO A CA  1 
ATOM   1065 C  C   . PRO A 1 188 ? 165.159 217.976 179.554 1.00 18.01 ? 188  PRO A C   1 
ATOM   1066 O  O   . PRO A 1 188 ? 165.413 216.901 178.994 1.00 18.01 ? 188  PRO A O   1 
ATOM   1067 C  CB  . PRO A 1 188 ? 162.886 218.417 180.567 1.00 18.01 ? 188  PRO A CB  1 
ATOM   1068 C  CG  . PRO A 1 188 ? 162.507 219.301 181.699 1.00 18.01 ? 188  PRO A CG  1 
ATOM   1069 C  CD  . PRO A 1 188 ? 163.756 219.929 182.221 1.00 18.01 ? 188  PRO A CD  1 
ATOM   1070 N  N   . THR A 1 189 ? 165.589 219.148 179.086 1.00 15.69 ? 189  THR A N   1 
ATOM   1071 C  CA  . THR A 1 189 ? 166.440 219.209 177.904 1.00 15.69 ? 189  THR A CA  1 
ATOM   1072 C  C   . THR A 1 189 ? 167.756 218.486 178.152 1.00 15.69 ? 189  THR A C   1 
ATOM   1073 O  O   . THR A 1 189 ? 168.283 217.808 177.264 1.00 15.69 ? 189  THR A O   1 
ATOM   1074 C  CB  . THR A 1 189 ? 166.692 220.666 177.513 1.00 15.69 ? 189  THR A CB  1 
ATOM   1075 N  N   . VAL A 1 190 ? 168.305 218.624 179.359 1.00 15.36 ? 190  VAL A N   1 
ATOM   1076 C  CA  . VAL A 1 190 ? 169.537 217.920 179.696 1.00 15.36 ? 190  VAL A CA  1 
ATOM   1077 C  C   . VAL A 1 190 ? 169.326 216.413 179.621 1.00 15.36 ? 190  VAL A C   1 
ATOM   1078 O  O   . VAL A 1 190 ? 170.182 215.676 179.119 1.00 15.36 ? 190  VAL A O   1 
ATOM   1079 C  CB  . VAL A 1 190 ? 170.033 218.351 181.089 1.00 15.36 ? 190  VAL A CB  1 
ATOM   1080 N  N   . TRP A 1 191 ? 168.188 215.930 180.127 1.00 14.25 ? 191  TRP A N   1 
ATOM   1081 C  CA  . TRP A 1 191 ? 167.902 214.499 180.067 1.00 14.25 ? 191  TRP A CA  1 
ATOM   1082 C  C   . TRP A 1 191 ? 167.751 214.024 178.626 1.00 14.25 ? 191  TRP A C   1 
ATOM   1083 O  O   . TRP A 1 191 ? 168.245 212.949 178.262 1.00 14.25 ? 191  TRP A O   1 
ATOM   1084 C  CB  . TRP A 1 191 ? 166.639 214.187 180.869 1.00 14.25 ? 191  TRP A CB  1 
ATOM   1085 N  N   . LEU A 1 192 ? 167.063 214.807 177.792 1.00 11.82 ? 192  LEU A N   1 
ATOM   1086 C  CA  . LEU A 1 192 ? 166.931 214.435 176.387 1.00 11.82 ? 192  LEU A CA  1 
ATOM   1087 C  C   . LEU A 1 192 ? 168.293 214.390 175.706 1.00 11.82 ? 192  LEU A C   1 
ATOM   1088 O  O   . LEU A 1 192 ? 168.574 213.478 174.920 1.00 11.82 ? 192  LEU A O   1 
ATOM   1089 C  CB  . LEU A 1 192 ? 166.004 215.414 175.668 1.00 11.82 ? 192  LEU A CB  1 
ATOM   1090 N  N   . SER A 1 193 ? 169.153 215.368 176.000 1.00 12.91 ? 193  SER A N   1 
ATOM   1091 C  CA  . SER A 1 193 ? 170.499 215.370 175.434 1.00 12.91 ? 193  SER A CA  1 
ATOM   1092 C  C   . SER A 1 193 ? 171.292 214.157 175.900 1.00 12.91 ? 193  SER A C   1 
ATOM   1093 O  O   . SER A 1 193 ? 172.023 213.545 175.115 1.00 12.91 ? 193  SER A O   1 
ATOM   1094 C  CB  . SER A 1 193 ? 171.225 216.660 175.817 1.00 12.91 ? 193  SER A CB  1 
ATOM   1095 N  N   . VAL A 1 194 ? 171.165 213.797 177.178 1.00 11.18 ? 194  VAL A N   1 
ATOM   1096 C  CA  . VAL A 1 194 ? 171.879 212.635 177.697 1.00 11.18 ? 194  VAL A CA  1 
ATOM   1097 C  C   . VAL A 1 194 ? 171.418 211.369 176.990 1.00 11.18 ? 194  VAL A C   1 
ATOM   1098 O  O   . VAL A 1 194 ? 172.234 210.528 176.593 1.00 11.18 ? 194  VAL A O   1 
ATOM   1099 C  CB  . VAL A 1 194 ? 171.688 212.531 179.221 1.00 11.18 ? 194  VAL A CB  1 
ATOM   1100 N  N   . ILE A 1 195 ? 170.103 211.210 176.822 1.00 9.14  ? 195  ILE A N   1 
ATOM   1101 C  CA  . ILE A 1 195 ? 169.585 210.009 176.169 1.00 9.14  ? 195  ILE A CA  1 
ATOM   1102 C  C   . ILE A 1 195 ? 170.026 209.962 174.711 1.00 9.14  ? 195  ILE A C   1 
ATOM   1103 O  O   . ILE A 1 195 ? 170.402 208.902 174.194 1.00 9.14  ? 195  ILE A O   1 
ATOM   1104 C  CB  . ILE A 1 195 ? 168.053 209.947 176.301 1.00 9.14  ? 195  ILE A CB  1 
ATOM   1105 C  CG1 . ILE A 1 195 ? 167.659 209.582 177.734 1.00 9.14  ? 195  ILE A CG1 1 
ATOM   1106 C  CG2 . ILE A 1 195 ? 167.478 208.937 175.322 1.00 9.14  ? 195  ILE A CG2 1 
ATOM   1107 C  CD1 . ILE A 1 195 ? 166.174 209.360 177.924 1.00 9.14  ? 195  ILE A CD1 1 
ATOM   1108 N  N   . TRP A 1 196 ? 169.984 211.103 174.022 1.00 9.25  ? 196  TRP A N   1 
ATOM   1109 C  CA  . TRP A 1 196 ? 170.425 211.130 172.632 1.00 9.25  ? 196  TRP A CA  1 
ATOM   1110 C  C   . TRP A 1 196 ? 171.909 210.805 172.518 1.00 9.25  ? 196  TRP A C   1 
ATOM   1111 O  O   . TRP A 1 196 ? 172.323 210.085 171.603 1.00 9.25  ? 196  TRP A O   1 
ATOM   1112 C  CB  . TRP A 1 196 ? 170.123 212.493 172.011 1.00 9.25  ? 196  TRP A CB  1 
ATOM   1113 C  CG  . TRP A 1 196 ? 168.738 212.610 171.435 1.00 9.25  ? 196  TRP A CG  1 
ATOM   1114 C  CD1 . TRP A 1 196 ? 167.703 211.735 171.597 1.00 9.25  ? 196  TRP A CD1 1 
ATOM   1115 C  CD2 . TRP A 1 196 ? 168.243 213.665 170.600 1.00 9.25  ? 196  TRP A CD2 1 
ATOM   1116 N  NE1 . TRP A 1 196 ? 166.596 212.180 170.918 1.00 9.25  ? 196  TRP A NE1 1 
ATOM   1117 C  CE2 . TRP A 1 196 ? 166.901 213.363 170.298 1.00 9.25  ? 196  TRP A CE2 1 
ATOM   1118 C  CE3 . TRP A 1 196 ? 168.805 214.835 170.080 1.00 9.25  ? 196  TRP A CE3 1 
ATOM   1119 C  CZ2 . TRP A 1 196 ? 166.112 214.188 169.500 1.00 9.25  ? 196  TRP A CZ2 1 
ATOM   1120 C  CZ3 . TRP A 1 196 ? 168.021 215.652 169.290 1.00 9.25  ? 196  TRP A CZ3 1 
ATOM   1121 C  CH2 . TRP A 1 196 ? 166.688 215.325 169.007 1.00 9.25  ? 196  TRP A CH2 1 
ATOM   1122 N  N   . MET A 1 197 ? 172.729 211.333 173.428 1.00 10.68 ? 197  MET A N   1 
ATOM   1123 C  CA  . MET A 1 197 ? 174.154 211.018 173.407 1.00 10.68 ? 197  MET A CA  1 
ATOM   1124 C  C   . MET A 1 197 ? 174.390 209.537 173.672 1.00 10.68 ? 197  MET A C   1 
ATOM   1125 O  O   . MET A 1 197 ? 175.263 208.918 173.054 1.00 10.68 ? 197  MET A O   1 
ATOM   1126 C  CB  . MET A 1 197 ? 174.894 211.873 174.435 1.00 10.68 ? 197  MET A CB  1 
ATOM   1127 N  N   . MET A 1 198 ? 173.621 208.951 174.594 1.00 10.03 ? 198  MET A N   1 
ATOM   1128 C  CA  . MET A 1 198 ? 173.713 207.513 174.818 1.00 10.03 ? 198  MET A CA  1 
ATOM   1129 C  C   . MET A 1 198 ? 173.360 206.738 173.557 1.00 10.03 ? 198  MET A C   1 
ATOM   1130 O  O   . MET A 1 198 ? 174.013 205.739 173.237 1.00 10.03 ? 198  MET A O   1 
ATOM   1131 C  CB  . MET A 1 198 ? 172.793 207.103 175.967 1.00 10.03 ? 198  MET A CB  1 
ATOM   1132 N  N   . TRP A 1 199 ? 172.333 207.183 172.831 1.00 8.10  ? 199  TRP A N   1 
ATOM   1133 C  CA  . TRP A 1 199 ? 172.009 206.563 171.550 1.00 8.10  ? 199  TRP A CA  1 
ATOM   1134 C  C   . TRP A 1 199 ? 173.183 206.681 170.586 1.00 8.10  ? 199  TRP A C   1 
ATOM   1135 O  O   . TRP A 1 199 ? 173.530 205.725 169.884 1.00 8.10  ? 199  TRP A O   1 
ATOM   1136 C  CB  . TRP A 1 199 ? 170.761 207.215 170.956 1.00 8.10  ? 199  TRP A CB  1 
ATOM   1137 C  CG  . TRP A 1 199 ? 170.030 206.351 169.980 1.00 8.10  ? 199  TRP A CG  1 
ATOM   1138 C  CD1 . TRP A 1 199 ? 170.522 205.268 169.313 1.00 8.10  ? 199  TRP A CD1 1 
ATOM   1139 C  CD2 . TRP A 1 199 ? 168.672 206.503 169.551 1.00 8.10  ? 199  TRP A CD2 1 
ATOM   1140 N  NE1 . TRP A 1 199 ? 169.553 204.732 168.500 1.00 8.10  ? 199  TRP A NE1 1 
ATOM   1141 C  CE2 . TRP A 1 199 ? 168.408 205.474 168.628 1.00 8.10  ? 199  TRP A CE2 1 
ATOM   1142 C  CE3 . TRP A 1 199 ? 167.653 207.408 169.861 1.00 8.10  ? 199  TRP A CE3 1 
ATOM   1143 C  CZ2 . TRP A 1 199 ? 167.167 205.325 168.011 1.00 8.10  ? 199  TRP A CZ2 1 
ATOM   1144 C  CZ3 . TRP A 1 199 ? 166.423 207.259 169.247 1.00 8.10  ? 199  TRP A CZ3 1 
ATOM   1145 C  CH2 . TRP A 1 199 ? 166.191 206.226 168.333 1.00 8.10  ? 199  TRP A CH2 1 
ATOM   1146 N  N   . TYR A 1 200 ? 173.805 207.861 170.538 1.00 10.94 ? 200  TYR A N   1 
ATOM   1147 C  CA  . TYR A 1 200 ? 175.031 208.035 169.769 1.00 10.94 ? 200  TYR A CA  1 
ATOM   1148 C  C   . TYR A 1 200 ? 176.185 207.249 170.371 1.00 10.94 ? 200  TYR A C   1 
ATOM   1149 O  O   . TYR A 1 200 ? 177.099 206.835 169.648 1.00 10.94 ? 200  TYR A O   1 
ATOM   1150 C  CB  . TYR A 1 200 ? 175.392 209.520 169.698 1.00 10.94 ? 200  TYR A CB  1 
ATOM   1151 C  CG  . TYR A 1 200 ? 176.544 209.847 168.773 1.00 10.94 ? 200  TYR A CG  1 
ATOM   1152 C  CD1 . TYR A 1 200 ? 176.659 209.251 167.526 1.00 10.94 ? 200  TYR A CD1 1 
ATOM   1153 C  CD2 . TYR A 1 200 ? 177.523 210.754 169.155 1.00 10.94 ? 200  TYR A CD2 1 
ATOM   1154 C  CE1 . TYR A 1 200 ? 177.715 209.552 166.685 1.00 10.94 ? 200  TYR A CE1 1 
ATOM   1155 C  CE2 . TYR A 1 200 ? 178.580 211.061 168.323 1.00 10.94 ? 200  TYR A CE2 1 
ATOM   1156 C  CZ  . TYR A 1 200 ? 178.673 210.457 167.091 1.00 10.94 ? 200  TYR A CZ  1 
ATOM   1157 O  OH  . TYR A 1 200 ? 179.727 210.762 166.261 1.00 10.94 ? 200  TYR A OH  1 
ATOM   1158 N  N   . TRP A 1 201 ? 176.169 207.041 171.685 1.00 12.94 ? 201  TRP A N   1 
ATOM   1159 C  CA  . TRP A 1 201 ? 177.246 206.357 172.383 1.00 12.94 ? 201  TRP A CA  1 
ATOM   1160 C  C   . TRP A 1 201 ? 176.947 204.886 172.634 1.00 12.94 ? 201  TRP A C   1 
ATOM   1161 O  O   . TRP A 1 201 ? 177.730 204.218 173.314 1.00 12.94 ? 201  TRP A O   1 
ATOM   1162 C  CB  . TRP A 1 201 ? 177.539 207.058 173.711 1.00 12.94 ? 201  TRP A CB  1 
ATOM   1163 N  N   . GLY A 1 202 ? 175.839 204.366 172.112 1.00 14.27 ? 202  GLY A N   1 
ATOM   1164 C  CA  . GLY A 1 202 ? 175.532 202.963 172.252 1.00 14.27 ? 202  GLY A CA  1 
ATOM   1165 C  C   . GLY A 1 202 ? 176.579 202.104 171.574 1.00 14.27 ? 202  GLY A C   1 
ATOM   1166 O  O   . GLY A 1 202 ? 177.209 201.237 172.191 1.00 14.27 ? 202  GLY A O   1 
ATOM   1167 N  N   . PRO A 1 203 ? 176.780 202.330 170.272 1.00 12.23 ? 203  PRO A N   1 
ATOM   1168 C  CA  . PRO A 1 203 ? 177.918 201.682 169.605 1.00 12.23 ? 203  PRO A CA  1 
ATOM   1169 C  C   . PRO A 1 203 ? 179.234 201.986 170.291 1.00 12.23 ? 203  PRO A C   1 
ATOM   1170 O  O   . PRO A 1 203 ? 180.082 201.096 170.417 1.00 12.23 ? 203  PRO A O   1 
ATOM   1171 C  CB  . PRO A 1 203 ? 177.873 202.253 168.182 1.00 12.23 ? 203  PRO A CB  1 
ATOM   1172 C  CG  . PRO A 1 203 ? 176.491 202.766 167.990 1.00 12.23 ? 203  PRO A CG  1 
ATOM   1173 C  CD  . PRO A 1 203 ? 175.845 202.960 169.327 1.00 12.23 ? 203  PRO A CD  1 
ATOM   1174 N  N   . SER A 1 204 ? 179.427 203.222 170.754 1.00 16.99 ? 204  SER A N   1 
ATOM   1175 C  CA  . SER A 1 204 ? 180.610 203.533 171.548 1.00 16.99 ? 204  SER A CA  1 
ATOM   1176 C  C   . SER A 1 204 ? 180.490 202.951 172.950 1.00 16.99 ? 204  SER A C   1 
ATOM   1177 O  O   . SER A 1 204 ? 181.499 202.734 173.630 1.00 16.99 ? 204  SER A O   1 
ATOM   1178 C  CB  . SER A 1 204 ? 180.819 205.046 171.611 1.00 16.99 ? 204  SER A CB  1 
ATOM   1179 N  N   . LEU A 1 205 ? 179.260 202.702 173.405 1.00 16.78 ? 205  LEU A N   1 
ATOM   1180 C  CA  . LEU A 1 205 ? 179.073 202.057 174.700 1.00 16.78 ? 205  LEU A CA  1 
ATOM   1181 C  C   . LEU A 1 205 ? 179.644 200.647 174.687 1.00 16.78 ? 205  LEU A C   1 
ATOM   1182 O  O   . LEU A 1 205 ? 180.308 200.226 175.642 1.00 16.78 ? 205  LEU A O   1 
ATOM   1183 C  CB  . LEU A 1 205 ? 177.589 202.032 175.067 1.00 16.78 ? 205  LEU A CB  1 
ATOM   1184 N  N   . TYR A 1 206 ? 179.398 199.906 173.613 1.00 14.45 ? 206  TYR A N   1 
ATOM   1185 C  CA  . TYR A 1 206 ? 179.951 198.569 173.459 1.00 14.45 ? 206  TYR A CA  1 
ATOM   1186 C  C   . TYR A 1 206 ? 181.284 198.559 172.719 1.00 14.45 ? 206  TYR A C   1 
ATOM   1187 O  O   . TYR A 1 206 ? 181.879 197.489 172.560 1.00 14.45 ? 206  TYR A O   1 
ATOM   1188 C  CB  . TYR A 1 206 ? 178.940 197.664 172.746 1.00 14.45 ? 206  TYR A CB  1 
ATOM   1189 C  CG  . TYR A 1 206 ? 177.772 197.236 173.617 1.00 14.45 ? 206  TYR A CG  1 
ATOM   1190 C  CD1 . TYR A 1 206 ? 177.944 196.967 174.971 1.00 14.45 ? 206  TYR A CD1 1 
ATOM   1191 C  CD2 . TYR A 1 206 ? 176.496 197.112 173.086 1.00 14.45 ? 206  TYR A CD2 1 
ATOM   1192 C  CE1 . TYR A 1 206 ? 176.881 196.577 175.764 1.00 14.45 ? 206  TYR A CE1 1 
ATOM   1193 C  CE2 . TYR A 1 206 ? 175.425 196.725 173.874 1.00 14.45 ? 206  TYR A CE2 1 
ATOM   1194 C  CZ  . TYR A 1 206 ? 175.623 196.460 175.212 1.00 14.45 ? 206  TYR A CZ  1 
ATOM   1195 O  OH  . TYR A 1 206 ? 174.561 196.076 175.998 1.00 14.45 ? 206  TYR A OH  1 
ATOM   1196 N  N   . SER A 1 207 ? 181.773 199.718 172.275 1.00 15.65 ? 207  SER A N   1 
ATOM   1197 C  CA  . SER A 1 207 ? 183.139 199.806 171.778 1.00 15.65 ? 207  SER A CA  1 
ATOM   1198 C  C   . SER A 1 207 ? 184.157 199.549 172.876 1.00 15.65 ? 207  SER A C   1 
ATOM   1199 O  O   . SER A 1 207 ? 185.317 199.251 172.575 1.00 15.65 ? 207  SER A O   1 
ATOM   1200 C  CB  . SER A 1 207 ? 183.389 201.181 171.157 1.00 15.65 ? 207  SER A CB  1 
ATOM   1201 N  N   . ILE A 1 208 ? 183.747 199.673 174.135 1.00 16.13 ? 208  ILE A N   1 
ATOM   1202 C  CA  . ILE A 1 208 ? 184.536 199.241 175.276 1.00 16.13 ? 208  ILE A CA  1 
ATOM   1203 C  C   . ILE A 1 208 ? 183.965 197.954 175.870 1.00 16.13 ? 208  ILE A C   1 
ATOM   1204 O  O   . ILE A 1 208 ? 184.231 197.632 177.027 1.00 16.13 ? 208  ILE A O   1 
ATOM   1205 C  CB  . ILE A 1 208 ? 184.631 200.350 176.336 1.00 16.13 ? 208  ILE A CB  1 
ATOM   1206 N  N   . LEU A 1 209 ? 183.172 197.218 175.087 1.00 15.87 ? 209  LEU A N   1 
ATOM   1207 C  CA  . LEU A 1 209 ? 182.602 195.967 175.575 1.00 15.87 ? 209  LEU A CA  1 
ATOM   1208 C  C   . LEU A 1 209 ? 183.689 194.937 175.854 1.00 15.87 ? 209  LEU A C   1 
ATOM   1209 O  O   . LEU A 1 209 ? 183.607 194.191 176.837 1.00 15.87 ? 209  LEU A O   1 
ATOM   1210 C  CB  . LEU A 1 209 ? 181.595 195.421 174.564 1.00 15.87 ? 209  LEU A CB  1 
ATOM   1211 N  N   . SER A 1 210 ? 184.708 194.872 174.998 1.00 14.89 ? 210  SER A N   1 
ATOM   1212 C  CA  . SER A 1 210 ? 185.799 193.935 175.240 1.00 14.89 ? 210  SER A CA  1 
ATOM   1213 C  C   . SER A 1 210 ? 186.476 194.181 176.579 1.00 14.89 ? 210  SER A C   1 
ATOM   1214 O  O   . SER A 1 210 ? 186.643 193.213 177.343 1.00 14.89 ? 210  SER A O   1 
ATOM   1215 C  CB  . SER A 1 210 ? 186.813 194.017 174.094 1.00 14.89 ? 210  SER A CB  1 
ATOM   1216 N  N   . PRO A 1 211 ? 186.874 195.407 176.932 1.00 18.17 ? 211  PRO A N   1 
ATOM   1217 C  CA  . PRO A 1 211 ? 187.380 195.654 178.293 1.00 18.17 ? 211  PRO A CA  1 
ATOM   1218 C  C   . PRO A 1 211 ? 186.377 195.335 179.394 1.00 18.17 ? 211  PRO A C   1 
ATOM   1219 O  O   . PRO A 1 211 ? 186.768 195.320 180.568 1.00 18.17 ? 211  PRO A O   1 
ATOM   1220 C  CB  . PRO A 1 211 ? 187.713 197.152 178.281 1.00 18.17 ? 211  PRO A CB  1 
ATOM   1221 C  CG  . PRO A 1 211 ? 187.895 197.520 176.849 1.00 18.17 ? 211  PRO A CG  1 
ATOM   1222 C  CD  . PRO A 1 211 ? 187.199 196.499 175.998 1.00 18.17 ? 211  PRO A CD  1 
ATOM   1223 N  N   . PHE A 1 212 ? 185.107 195.087 179.061 1.00 18.28 ? 212  PHE A N   1 
ATOM   1224 C  CA  . PHE A 1 212 ? 184.094 194.897 180.095 1.00 18.28 ? 212  PHE A CA  1 
ATOM   1225 C  C   . PHE A 1 212 ? 184.396 193.681 180.962 1.00 18.28 ? 212  PHE A C   1 
ATOM   1226 O  O   . PHE A 1 212 ? 184.264 193.739 182.190 1.00 18.28 ? 212  PHE A O   1 
ATOM   1227 C  CB  . PHE A 1 212 ? 182.714 194.761 179.453 1.00 18.28 ? 212  PHE A CB  1 
ATOM   1228 N  N   . LEU A 1 213 ? 184.798 192.570 180.348 1.00 18.80 ? 213  LEU A N   1 
ATOM   1229 C  CA  . LEU A 1 213 ? 185.032 191.355 181.123 1.00 18.80 ? 213  LEU A CA  1 
ATOM   1230 C  C   . LEU A 1 213 ? 186.021 191.572 182.260 1.00 18.80 ? 213  LEU A C   1 
ATOM   1231 O  O   . LEU A 1 213 ? 185.723 191.151 183.391 1.00 18.80 ? 213  LEU A O   1 
ATOM   1232 C  CB  . LEU A 1 213 ? 185.513 190.235 180.193 1.00 18.80 ? 213  LEU A CB  1 
ATOM   1233 N  N   . PRO A 1 214 ? 187.179 192.202 182.050 1.00 22.45 ? 214  PRO A N   1 
ATOM   1234 C  CA  . PRO A 1 214 ? 188.072 192.493 183.182 1.00 22.45 ? 214  PRO A CA  1 
ATOM   1235 C  C   . PRO A 1 214 ? 187.446 193.359 184.262 1.00 22.45 ? 214  PRO A C   1 
ATOM   1236 O  O   . PRO A 1 214 ? 188.012 193.442 185.359 1.00 22.45 ? 214  PRO A O   1 
ATOM   1237 C  CB  . PRO A 1 214 ? 189.255 193.211 182.520 1.00 22.45 ? 214  PRO A CB  1 
ATOM   1238 C  CG  . PRO A 1 214 ? 189.273 192.700 181.121 1.00 22.45 ? 214  PRO A CG  1 
ATOM   1239 C  CD  . PRO A 1 214 ? 187.849 192.382 180.750 1.00 22.45 ? 214  PRO A CD  1 
ATOM   1240 N  N   . LEU A 1 215 ? 186.309 194.009 183.993 1.00 20.79 ? 215  LEU A N   1 
ATOM   1241 C  CA  . LEU A 1 215 ? 185.757 194.966 184.949 1.00 20.79 ? 215  LEU A CA  1 
ATOM   1242 C  C   . LEU A 1 215 ? 185.583 194.343 186.327 1.00 20.79 ? 215  LEU A C   1 
ATOM   1243 O  O   . LEU A 1 215 ? 185.978 194.933 187.339 1.00 20.79 ? 215  LEU A O   1 
ATOM   1244 C  CB  . LEU A 1 215 ? 184.421 195.508 184.436 1.00 20.79 ? 215  LEU A CB  1 
ATOM   1245 N  N   . LEU A 1 216 ? 184.992 193.152 186.389 1.00 19.59 ? 216  LEU A N   1 
ATOM   1246 C  CA  . LEU A 1 216 ? 184.848 192.471 187.674 1.00 19.59 ? 216  LEU A CA  1 
ATOM   1247 C  C   . LEU A 1 216 ? 186.192 192.214 188.334 1.00 19.59 ? 216  LEU A C   1 
ATOM   1248 O  O   . LEU A 1 216 ? 186.319 192.455 189.547 1.00 19.59 ? 216  LEU A O   1 
ATOM   1249 C  CB  . LEU A 1 216 ? 184.071 191.167 187.479 1.00 19.59 ? 216  LEU A CB  1 
ATOM   1250 N  N   . PRO A 1 217 ? 187.218 191.738 187.625 1.00 23.49 ? 217  PRO A N   1 
ATOM   1251 C  CA  . PRO A 1 217 ? 188.503 191.460 188.281 1.00 23.49 ? 217  PRO A CA  1 
ATOM   1252 C  C   . PRO A 1 217 ? 189.137 192.700 188.890 1.00 23.49 ? 217  PRO A C   1 
ATOM   1253 O  O   . PRO A 1 217 ? 189.425 192.729 190.092 1.00 23.49 ? 217  PRO A O   1 
ATOM   1254 C  CB  . PRO A 1 217 ? 189.360 190.895 187.141 1.00 23.49 ? 217  PRO A CB  1 
ATOM   1255 N  N   . ILE A 1 218 ? 189.348 193.735 188.075 1.00 23.44 ? 218  ILE A N   1 
ATOM   1256 C  CA  . ILE A 1 218 ? 190.001 194.941 188.576 1.00 23.44 ? 218  ILE A CA  1 
ATOM   1257 C  C   . ILE A 1 218 ? 189.186 195.548 189.710 1.00 23.44 ? 218  ILE A C   1 
ATOM   1258 O  O   . ILE A 1 218 ? 189.727 195.889 190.769 1.00 23.44 ? 218  ILE A O   1 
ATOM   1259 C  CB  . ILE A 1 218 ? 190.229 195.944 187.428 1.00 23.44 ? 218  ILE A CB  1 
ATOM   1260 C  CG1 . ILE A 1 218 ? 191.133 197.086 187.892 1.00 23.44 ? 218  ILE A CG1 1 
ATOM   1261 C  CG2 . ILE A 1 218 ? 188.910 196.492 186.905 1.00 23.44 ? 218  ILE A CG2 1 
ATOM   1262 C  CD1 . ILE A 1 218 ? 191.664 197.929 186.758 1.00 23.44 ? 218  ILE A CD1 1 
ATOM   1263 N  N   . PHE A 1 219 ? 187.870 195.664 189.523 1.00 22.78 ? 219  PHE A N   1 
ATOM   1264 C  CA  . PHE A 1 219 ? 187.018 196.096 190.624 1.00 22.78 ? 219  PHE A CA  1 
ATOM   1265 C  C   . PHE A 1 219 ? 187.153 195.145 191.803 1.00 22.78 ? 219  PHE A C   1 
ATOM   1266 O  O   . PHE A 1 219 ? 187.291 195.581 192.952 1.00 22.78 ? 219  PHE A O   1 
ATOM   1267 C  CB  . PHE A 1 219 ? 185.563 196.182 190.162 1.00 22.78 ? 219  PHE A CB  1 
ATOM   1268 N  N   . PHE A 1 220 ? 187.142 193.836 191.531 1.00 22.21 ? 220  PHE A N   1 
ATOM   1269 C  CA  . PHE A 1 220 ? 187.439 192.866 192.578 1.00 22.21 ? 220  PHE A CA  1 
ATOM   1270 C  C   . PHE A 1 220 ? 188.770 193.185 193.240 1.00 22.21 ? 220  PHE A C   1 
ATOM   1271 O  O   . PHE A 1 220 ? 188.877 193.182 194.472 1.00 22.21 ? 220  PHE A O   1 
ATOM   1272 C  CB  . PHE A 1 220 ? 187.455 191.454 191.997 1.00 22.21 ? 220  PHE A CB  1 
ATOM   1273 N  N   . CYS A 1 221 ? 189.793 193.484 192.434 1.00 25.74 ? 221  CYS A N   1 
ATOM   1274 C  CA  . CYS A 1 221 ? 191.070 193.906 192.996 1.00 25.74 ? 221  CYS A CA  1 
ATOM   1275 C  C   . CYS A 1 221 ? 190.880 195.098 193.923 1.00 25.74 ? 221  CYS A C   1 
ATOM   1276 O  O   . CYS A 1 221 ? 191.399 195.112 195.046 1.00 25.74 ? 221  CYS A O   1 
ATOM   1277 C  CB  . CYS A 1 221 ? 192.049 194.247 191.874 1.00 25.74 ? 221  CYS A CB  1 
ATOM   1278 N  N   . LEU A 1 222 ? 190.118 196.099 193.479 1.00 22.75 ? 222  LEU A N   1 
ATOM   1279 C  CA  . LEU A 1 222 ? 189.790 197.209 194.363 1.00 22.75 ? 222  LEU A CA  1 
ATOM   1280 C  C   . LEU A 1 222 ? 189.186 196.699 195.661 1.00 22.75 ? 222  LEU A C   1 
ATOM   1281 O  O   . LEU A 1 222 ? 189.622 197.084 196.753 1.00 22.75 ? 222  LEU A O   1 
ATOM   1282 C  CB  . LEU A 1 222 ? 188.825 198.165 193.664 1.00 22.75 ? 222  LEU A CB  1 
ATOM   1283 N  N   . TRP A 1 223 ? 188.201 195.803 195.561 1.00 25.03 ? 223  TRP A N   1 
ATOM   1284 C  CA  . TRP A 1 223 ? 187.575 195.255 196.758 1.00 25.03 ? 223  TRP A CA  1 
ATOM   1285 C  C   . TRP A 1 223 ? 188.606 194.594 197.660 1.00 25.03 ? 223  TRP A C   1 
ATOM   1286 O  O   . TRP A 1 223 ? 188.490 194.644 198.890 1.00 25.03 ? 223  TRP A O   1 
ATOM   1287 C  CB  . TRP A 1 223 ? 186.485 194.257 196.368 1.00 25.03 ? 223  TRP A CB  1 
ATOM   1288 N  N   . VAL A 1 224 ? 189.622 193.963 197.068 1.00 26.62 ? 224  VAL A N   1 
ATOM   1289 C  CA  . VAL A 1 224 ? 190.694 193.388 197.873 1.00 26.62 ? 224  VAL A CA  1 
ATOM   1290 C  C   . VAL A 1 224 ? 191.515 194.495 198.520 1.00 26.62 ? 224  VAL A C   1 
ATOM   1291 O  O   . VAL A 1 224 ? 191.820 194.445 199.718 1.00 26.62 ? 224  VAL A O   1 
ATOM   1292 C  CB  . VAL A 1 224 ? 191.571 192.462 197.010 1.00 26.62 ? 224  VAL A CB  1 
ATOM   1293 N  N   . TYR A 1 225 ? 191.882 195.514 197.741 1.00 29.75 ? 225  TYR A N   1 
ATOM   1294 C  CA  . TYR A 1 225 ? 192.673 196.611 198.286 1.00 29.75 ? 225  TYR A CA  1 
ATOM   1295 C  C   . TYR A 1 225 ? 191.821 197.524 199.158 1.00 29.75 ? 225  TYR A C   1 
ATOM   1296 O  O   . TYR A 1 225 ? 192.339 198.201 200.054 1.00 29.75 ? 225  TYR A O   1 
ATOM   1297 C  CB  . TYR A 1 225 ? 193.321 197.402 197.150 1.00 29.75 ? 225  TYR A CB  1 
ATOM   1298 N  N   . ILE A 1 226 ? 190.517 197.563 198.905 1.00 31.02 ? 226  ILE A N   1 
ATOM   1299 C  CA  . ILE A 1 226 ? 189.611 198.425 199.654 1.00 31.02 ? 226  ILE A CA  1 
ATOM   1300 C  C   . ILE A 1 226 ? 189.751 198.173 201.150 1.00 31.02 ? 226  ILE A C   1 
ATOM   1301 O  O   . ILE A 1 226 ? 190.470 198.892 201.844 1.00 31.02 ? 226  ILE A O   1 
ATOM   1302 C  CB  . ILE A 1 226 ? 188.156 198.218 199.207 1.00 31.02 ? 226  ILE A CB  1 
ATOM   1303 N  N   . LEU B 1 9   ? 189.747 186.702 200.272 1.00 18.67 ? 9    LEU B N   1 
ATOM   1304 C  CA  . LEU B 1 9   ? 189.708 185.628 199.288 1.00 18.67 ? 9    LEU B CA  1 
ATOM   1305 C  C   . LEU B 1 9   ? 188.267 185.309 198.909 1.00 18.67 ? 9    LEU B C   1 
ATOM   1306 O  O   . LEU B 1 9   ? 187.940 185.160 197.732 1.00 18.67 ? 9    LEU B O   1 
ATOM   1307 C  CB  . LEU B 1 9   ? 190.398 184.376 199.833 1.00 18.67 ? 9    LEU B CB  1 
ATOM   1308 C  CG  . LEU B 1 9   ? 191.904 184.493 200.082 1.00 18.67 ? 9    LEU B CG  1 
ATOM   1309 C  CD1 . LEU B 1 9   ? 192.431 183.233 200.749 1.00 18.67 ? 9    LEU B CD1 1 
ATOM   1310 C  CD2 . LEU B 1 9   ? 192.659 184.774 198.790 1.00 18.67 ? 9    LEU B CD2 1 
ATOM   1311 N  N   . GLY B 1 10  ? 187.410 185.200 199.919 1.00 16.84 ? 10   GLY B N   1 
ATOM   1312 C  CA  . GLY B 1 10  ? 186.010 184.922 199.712 1.00 16.84 ? 10   GLY B CA  1 
ATOM   1313 C  C   . GLY B 1 10  ? 185.287 185.991 198.915 1.00 16.84 ? 10   GLY B C   1 
ATOM   1314 O  O   . GLY B 1 10  ? 184.596 185.691 197.935 1.00 16.84 ? 10   GLY B O   1 
ATOM   1315 N  N   . PRO B 1 11  ? 185.419 187.260 199.318 1.00 17.10 ? 11   PRO B N   1 
ATOM   1316 C  CA  . PRO B 1 11  ? 184.698 188.322 198.594 1.00 17.10 ? 11   PRO B CA  1 
ATOM   1317 C  C   . PRO B 1 11  ? 185.072 188.425 197.127 1.00 17.10 ? 11   PRO B C   1 
ATOM   1318 O  O   . PRO B 1 11  ? 184.205 188.735 196.301 1.00 17.10 ? 11   PRO B O   1 
ATOM   1319 C  CB  . PRO B 1 11  ? 185.071 189.594 199.369 1.00 17.10 ? 11   PRO B CB  1 
ATOM   1320 C  CG  . PRO B 1 11  ? 186.254 189.230 200.195 1.00 17.10 ? 11   PRO B CG  1 
ATOM   1321 C  CD  . PRO B 1 11  ? 186.095 187.788 200.515 1.00 17.10 ? 11   PRO B CD  1 
ATOM   1322 N  N   . LEU B 1 12  ? 186.332 188.177 196.768 1.00 15.74 ? 12   LEU B N   1 
ATOM   1323 C  CA  . LEU B 1 12  ? 186.703 188.190 195.357 1.00 15.74 ? 12   LEU B CA  1 
ATOM   1324 C  C   . LEU B 1 12  ? 185.918 187.137 194.585 1.00 15.74 ? 12   LEU B C   1 
ATOM   1325 O  O   . LEU B 1 12  ? 185.386 187.408 193.501 1.00 15.74 ? 12   LEU B O   1 
ATOM   1326 C  CB  . LEU B 1 12  ? 188.207 187.958 195.209 1.00 15.74 ? 12   LEU B CB  1 
ATOM   1327 N  N   . LEU B 1 13  ? 185.827 185.926 195.139 1.00 16.84 ? 13   LEU B N   1 
ATOM   1328 C  CA  . LEU B 1 13  ? 185.077 184.861 194.483 1.00 16.84 ? 13   LEU B CA  1 
ATOM   1329 C  C   . LEU B 1 13  ? 183.595 185.204 194.402 1.00 16.84 ? 13   LEU B C   1 
ATOM   1330 O  O   . LEU B 1 13  ? 182.945 184.952 193.380 1.00 16.84 ? 13   LEU B O   1 
ATOM   1331 C  CB  . LEU B 1 13  ? 185.285 183.550 195.238 1.00 16.84 ? 13   LEU B CB  1 
ATOM   1332 C  CG  . LEU B 1 13  ? 186.718 183.011 195.205 1.00 16.84 ? 13   LEU B CG  1 
ATOM   1333 C  CD1 . LEU B 1 13  ? 186.847 181.784 196.100 1.00 16.84 ? 13   LEU B CD1 1 
ATOM   1334 C  CD2 . LEU B 1 13  ? 187.164 182.691 193.782 1.00 16.84 ? 13   LEU B CD2 1 
ATOM   1335 N  N   . VAL B 1 14  ? 183.045 185.783 195.471 1.00 16.97 ? 14   VAL B N   1 
ATOM   1336 C  CA  . VAL B 1 14  ? 181.637 186.173 195.466 1.00 16.97 ? 14   VAL B CA  1 
ATOM   1337 C  C   . VAL B 1 14  ? 181.372 187.187 194.361 1.00 16.97 ? 14   VAL B C   1 
ATOM   1338 O  O   . VAL B 1 14  ? 180.392 187.078 193.615 1.00 16.97 ? 14   VAL B O   1 
ATOM   1339 C  CB  . VAL B 1 14  ? 181.230 186.730 196.842 1.00 16.97 ? 14   VAL B CB  1 
ATOM   1340 C  CG1 . VAL B 1 14  ? 179.817 187.284 196.791 1.00 16.97 ? 14   VAL B CG1 1 
ATOM   1341 C  CG2 . VAL B 1 14  ? 181.342 185.652 197.904 1.00 16.97 ? 14   VAL B CG2 1 
ATOM   1342 N  N   . LEU B 1 15  ? 182.236 188.197 194.248 1.00 15.59 ? 15   LEU B N   1 
ATOM   1343 C  CA  . LEU B 1 15  ? 182.035 189.228 193.235 1.00 15.59 ? 15   LEU B CA  1 
ATOM   1344 C  C   . LEU B 1 15  ? 182.201 188.663 191.831 1.00 15.59 ? 15   LEU B C   1 
ATOM   1345 O  O   . LEU B 1 15  ? 181.457 189.036 190.916 1.00 15.59 ? 15   LEU B O   1 
ATOM   1346 C  CB  . LEU B 1 15  ? 182.998 190.393 193.464 1.00 15.59 ? 15   LEU B CB  1 
ATOM   1347 C  CG  . LEU B 1 15  ? 182.543 191.487 194.438 1.00 15.59 ? 15   LEU B CG  1 
ATOM   1348 C  CD1 . LEU B 1 15  ? 181.308 192.198 193.901 1.00 15.59 ? 15   LEU B CD1 1 
ATOM   1349 C  CD2 . LEU B 1 15  ? 182.284 190.950 195.838 1.00 15.59 ? 15   LEU B CD2 1 
ATOM   1350 N  N   . GLN B 1 16  ? 183.169 187.767 191.636 1.00 15.02 ? 16   GLN B N   1 
ATOM   1351 C  CA  . GLN B 1 16  ? 183.321 187.135 190.331 1.00 15.02 ? 16   GLN B CA  1 
ATOM   1352 C  C   . GLN B 1 16  ? 182.066 186.356 189.961 1.00 15.02 ? 16   GLN B C   1 
ATOM   1353 O  O   . GLN B 1 16  ? 181.579 186.439 188.827 1.00 15.02 ? 16   GLN B O   1 
ATOM   1354 C  CB  . GLN B 1 16  ? 184.544 186.219 190.332 1.00 15.02 ? 16   GLN B CB  1 
ATOM   1355 N  N   . ALA B 1 17  ? 181.525 185.593 190.912 1.00 14.43 ? 17   ALA B N   1 
ATOM   1356 C  CA  . ALA B 1 17  ? 180.314 184.828 190.640 1.00 14.43 ? 17   ALA B CA  1 
ATOM   1357 C  C   . ALA B 1 17  ? 179.146 185.749 190.318 1.00 14.43 ? 17   ALA B C   1 
ATOM   1358 O  O   . ALA B 1 17  ? 178.370 185.482 189.392 1.00 14.43 ? 17   ALA B O   1 
ATOM   1359 C  CB  . ALA B 1 17  ? 179.978 183.937 191.834 1.00 14.43 ? 17   ALA B CB  1 
ATOM   1360 N  N   . GLY B 1 18  ? 179.000 186.834 191.076 1.00 12.64 ? 18   GLY B N   1 
ATOM   1361 C  CA  . GLY B 1 18  ? 177.924 187.770 190.801 1.00 12.64 ? 18   GLY B CA  1 
ATOM   1362 C  C   . GLY B 1 18  ? 178.035 188.382 189.419 1.00 12.64 ? 18   GLY B C   1 
ATOM   1363 O  O   . GLY B 1 18  ? 177.045 188.480 188.690 1.00 12.64 ? 18   GLY B O   1 
ATOM   1364 N  N   . PHE B 1 19  ? 179.246 188.787 189.032 1.00 14.15 ? 19   PHE B N   1 
ATOM   1365 C  CA  . PHE B 1 19  ? 179.439 189.366 187.707 1.00 14.15 ? 19   PHE B CA  1 
ATOM   1366 C  C   . PHE B 1 19  ? 179.144 188.347 186.613 1.00 14.15 ? 19   PHE B C   1 
ATOM   1367 O  O   . PHE B 1 19  ? 178.523 188.678 185.597 1.00 14.15 ? 19   PHE B O   1 
ATOM   1368 C  CB  . PHE B 1 19  ? 180.865 189.903 187.575 1.00 14.15 ? 19   PHE B CB  1 
ATOM   1369 C  CG  . PHE B 1 19  ? 181.255 190.254 186.166 1.00 14.15 ? 19   PHE B CG  1 
ATOM   1370 C  CD1 . PHE B 1 19  ? 181.829 189.309 185.333 1.00 14.15 ? 19   PHE B CD1 1 
ATOM   1371 C  CD2 . PHE B 1 19  ? 181.042 191.531 185.675 1.00 14.15 ? 19   PHE B CD2 1 
ATOM   1372 C  CE1 . PHE B 1 19  ? 182.184 189.632 184.039 1.00 14.15 ? 19   PHE B CE1 1 
ATOM   1373 C  CE2 . PHE B 1 19  ? 181.395 191.859 184.382 1.00 14.15 ? 19   PHE B CE2 1 
ATOM   1374 C  CZ  . PHE B 1 19  ? 181.967 190.909 183.563 1.00 14.15 ? 19   PHE B CZ  1 
ATOM   1375 N  N   . PHE B 1 20  ? 179.590 187.104 186.794 1.00 11.66 ? 20   PHE B N   1 
ATOM   1376 C  CA  . PHE B 1 20  ? 179.354 186.088 185.775 1.00 11.66 ? 20   PHE B CA  1 
ATOM   1377 C  C   . PHE B 1 20  ? 177.867 185.784 185.633 1.00 11.66 ? 20   PHE B C   1 
ATOM   1378 O  O   . PHE B 1 20  ? 177.358 185.628 184.515 1.00 11.66 ? 20   PHE B O   1 
ATOM   1379 C  CB  . PHE B 1 20  ? 180.138 184.823 186.119 1.00 11.66 ? 20   PHE B CB  1 
ATOM   1380 C  CG  . PHE B 1 20  ? 179.850 183.666 185.213 1.00 11.66 ? 20   PHE B CG  1 
ATOM   1381 C  CD1 . PHE B 1 20  ? 180.150 183.737 183.864 1.00 11.66 ? 20   PHE B CD1 1 
ATOM   1382 C  CD2 . PHE B 1 20  ? 179.294 182.501 185.710 1.00 11.66 ? 20   PHE B CD2 1 
ATOM   1383 C  CE1 . PHE B 1 20  ? 179.891 182.673 183.026 1.00 11.66 ? 20   PHE B CE1 1 
ATOM   1384 C  CE2 . PHE B 1 20  ? 179.036 181.432 184.878 1.00 11.66 ? 20   PHE B CE2 1 
ATOM   1385 C  CZ  . PHE B 1 20  ? 179.335 181.518 183.533 1.00 11.66 ? 20   PHE B CZ  1 
ATOM   1386 N  N   . LEU B 1 21  ? 177.149 185.695 186.754 1.00 10.88 ? 21   LEU B N   1 
ATOM   1387 C  CA  . LEU B 1 21  ? 175.710 185.470 186.680 1.00 10.88 ? 21   LEU B CA  1 
ATOM   1388 C  C   . LEU B 1 21  ? 175.007 186.654 186.028 1.00 10.88 ? 21   LEU B C   1 
ATOM   1389 O  O   . LEU B 1 21  ? 174.057 186.477 185.254 1.00 10.88 ? 21   LEU B O   1 
ATOM   1390 C  CB  . LEU B 1 21  ? 175.148 185.209 188.076 1.00 10.88 ? 21   LEU B CB  1 
ATOM   1391 C  CG  . LEU B 1 21  ? 173.626 185.085 188.148 1.00 10.88 ? 21   LEU B CG  1 
ATOM   1392 C  CD1 . LEU B 1 21  ? 173.234 183.941 189.070 1.00 10.88 ? 21   LEU B CD1 1 
ATOM   1393 C  CD2 . LEU B 1 21  ? 172.996 186.389 188.609 1.00 10.88 ? 21   LEU B CD2 1 
ATOM   1394 N  N   . LEU B 1 22  ? 175.456 187.873 186.331 1.00 9.68  ? 22   LEU B N   1 
ATOM   1395 C  CA  . LEU B 1 22  ? 174.878 189.046 185.687 1.00 9.68  ? 22   LEU B CA  1 
ATOM   1396 C  C   . LEU B 1 22  ? 175.118 189.009 184.184 1.00 9.68  ? 22   LEU B C   1 
ATOM   1397 O  O   . LEU B 1 22  ? 174.239 189.378 183.399 1.00 9.68  ? 22   LEU B O   1 
ATOM   1398 C  CB  . LEU B 1 22  ? 175.462 190.315 186.308 1.00 9.68  ? 22   LEU B CB  1 
ATOM   1399 C  CG  . LEU B 1 22  ? 174.654 191.605 186.151 1.00 9.68  ? 22   LEU B CG  1 
ATOM   1400 C  CD1 . LEU B 1 22  ? 175.131 192.644 187.148 1.00 9.68  ? 22   LEU B CD1 1 
ATOM   1401 C  CD2 . LEU B 1 22  ? 174.755 192.154 184.745 1.00 9.68  ? 22   LEU B CD2 1 
ATOM   1402 N  N   . THR B 1 23  ? 176.302 188.562 183.762 1.00 9.13  ? 23   THR B N   1 
ATOM   1403 C  CA  . THR B 1 23  ? 176.559 188.397 182.335 1.00 9.13  ? 23   THR B CA  1 
ATOM   1404 C  C   . THR B 1 23  ? 175.628 187.365 181.713 1.00 9.13  ? 23   THR B C   1 
ATOM   1405 O  O   . THR B 1 23  ? 175.107 187.584 180.614 1.00 9.13  ? 23   THR B O   1 
ATOM   1406 C  CB  . THR B 1 23  ? 178.014 187.994 182.101 1.00 9.13  ? 23   THR B CB  1 
ATOM   1407 O  OG1 . THR B 1 23  ? 178.884 189.010 182.615 1.00 9.13  ? 23   THR B OG1 1 
ATOM   1408 C  CG2 . THR B 1 23  ? 178.285 187.794 180.616 1.00 9.13  ? 23   THR B CG2 1 
ATOM   1409 N  N   . ARG B 1 24  ? 175.418 186.233 182.388 1.00 8.24  ? 24   ARG B N   1 
ATOM   1410 C  CA  . ARG B 1 24  ? 174.466 185.247 181.884 1.00 8.24  ? 24   ARG B CA  1 
ATOM   1411 C  C   . ARG B 1 24  ? 173.090 185.873 181.686 1.00 8.24  ? 24   ARG B C   1 
ATOM   1412 O  O   . ARG B 1 24  ? 172.460 185.712 180.630 1.00 8.24  ? 24   ARG B O   1 
ATOM   1413 C  CB  . ARG B 1 24  ? 174.368 184.061 182.843 1.00 8.24  ? 24   ARG B CB  1 
ATOM   1414 C  CG  . ARG B 1 24  ? 175.498 183.048 182.757 1.00 8.24  ? 24   ARG B CG  1 
ATOM   1415 C  CD  . ARG B 1 24  ? 175.183 181.848 183.647 1.00 8.24  ? 24   ARG B CD  1 
ATOM   1416 N  NE  . ARG B 1 24  ? 176.233 180.837 183.639 1.00 8.24  ? 24   ARG B NE  1 
ATOM   1417 C  CZ  . ARG B 1 24  ? 176.201 179.720 184.355 1.00 8.24  ? 24   ARG B CZ  1 
ATOM   1418 N  NH1 . ARG B 1 24  ? 175.173 179.428 185.137 1.00 8.24  ? 24   ARG B NH1 1 
ATOM   1419 N  NH2 . ARG B 1 24  ? 177.226 178.876 184.287 1.00 8.24  ? 24   ARG B NH2 1 
ATOM   1420 N  N   . ILE B 1 25  ? 172.603 186.591 182.697 1.00 6.01  ? 25   ILE B N   1 
ATOM   1421 C  CA  . ILE B 1 25  ? 171.275 187.188 182.596 1.00 6.01  ? 25   ILE B CA  1 
ATOM   1422 C  C   . ILE B 1 25  ? 171.233 188.201 181.459 1.00 6.01  ? 25   ILE B C   1 
ATOM   1423 O  O   . ILE B 1 25  ? 170.265 188.256 180.694 1.00 6.01  ? 25   ILE B O   1 
ATOM   1424 C  CB  . ILE B 1 25  ? 170.867 187.823 183.938 1.00 6.01  ? 25   ILE B CB  1 
ATOM   1425 C  CG1 . ILE B 1 25  ? 170.861 186.772 185.053 1.00 6.01  ? 25   ILE B CG1 1 
ATOM   1426 C  CG2 . ILE B 1 25  ? 169.497 188.475 183.825 1.00 6.01  ? 25   ILE B CG2 1 
ATOM   1427 C  CD1 . ILE B 1 25  ? 169.887 185.628 184.837 1.00 6.01  ? 25   ILE B CD1 1 
ATOM   1428 N  N   . LEU B 1 26  ? 172.280 189.016 181.329 1.00 6.29  ? 26   LEU B N   1 
ATOM   1429 C  CA  . LEU B 1 26  ? 172.296 190.040 180.291 1.00 6.29  ? 26   LEU B CA  1 
ATOM   1430 C  C   . LEU B 1 26  ? 172.367 189.437 178.897 1.00 6.29  ? 26   LEU B C   1 
ATOM   1431 O  O   . LEU B 1 26  ? 171.888 190.051 177.937 1.00 6.29  ? 26   LEU B O   1 
ATOM   1432 C  CB  . LEU B 1 26  ? 173.475 190.988 180.507 1.00 6.29  ? 26   LEU B CB  1 
ATOM   1433 C  CG  . LEU B 1 26  ? 173.271 192.213 181.403 1.00 6.29  ? 26   LEU B CG  1 
ATOM   1434 C  CD1 . LEU B 1 26  ? 174.436 193.171 181.228 1.00 6.29  ? 26   LEU B CD1 1 
ATOM   1435 C  CD2 . LEU B 1 26  ? 171.959 192.931 181.116 1.00 6.29  ? 26   LEU B CD2 1 
ATOM   1436 N  N   . THR B 1 27  ? 172.972 188.260 178.754 1.00 4.32  ? 27   THR B N   1 
ATOM   1437 C  CA  . THR B 1 27  ? 173.033 187.609 177.454 1.00 4.32  ? 27   THR B CA  1 
ATOM   1438 C  C   . THR B 1 27  ? 171.853 186.686 177.198 1.00 4.32  ? 27   THR B C   1 
ATOM   1439 O  O   . THR B 1 27  ? 171.765 186.112 176.110 1.00 4.32  ? 27   THR B O   1 
ATOM   1440 C  CB  . THR B 1 27  ? 174.336 186.814 177.304 1.00 4.32  ? 27   THR B CB  1 
ATOM   1441 O  OG1 . THR B 1 27  ? 174.469 186.369 175.949 1.00 4.32  ? 27   THR B OG1 1 
ATOM   1442 C  CG2 . THR B 1 27  ? 174.352 185.606 178.223 1.00 4.32  ? 27   THR B CG2 1 
ATOM   1443 N  N   . ILE B 1 28  ? 170.967 186.503 178.171 1.00 3.46  ? 28   ILE B N   1 
ATOM   1444 C  CA  . ILE B 1 28  ? 169.742 185.742 177.920 1.00 3.46  ? 28   ILE B CA  1 
ATOM   1445 C  C   . ILE B 1 28  ? 169.001 186.309 176.711 1.00 3.46  ? 28   ILE B C   1 
ATOM   1446 O  O   . ILE B 1 28  ? 168.580 185.530 175.846 1.00 3.46  ? 28   ILE B O   1 
ATOM   1447 C  CB  . ILE B 1 28  ? 168.832 185.712 179.158 1.00 3.46  ? 28   ILE B CB  1 
ATOM   1448 C  CG1 . ILE B 1 28  ? 169.332 184.660 180.146 1.00 3.46  ? 28   ILE B CG1 1 
ATOM   1449 C  CG2 . ILE B 1 28  ? 167.393 185.423 178.757 1.00 3.46  ? 28   ILE B CG2 1 
ATOM   1450 C  CD1 . ILE B 1 28  ? 168.615 184.674 181.475 1.00 3.46  ? 28   ILE B CD1 1 
ATOM   1451 N  N   . PRO B 1 29  ? 168.805 187.629 176.599 1.00 2.13  ? 29   PRO B N   1 
ATOM   1452 C  CA  . PRO B 1 29  ? 168.094 188.161 175.420 1.00 2.13  ? 29   PRO B CA  1 
ATOM   1453 C  C   . PRO B 1 29  ? 168.694 187.744 174.086 1.00 2.13  ? 29   PRO B C   1 
ATOM   1454 O  O   . PRO B 1 29  ? 167.948 187.457 173.143 1.00 2.13  ? 29   PRO B O   1 
ATOM   1455 C  CB  . PRO B 1 29  ? 168.181 189.675 175.628 1.00 2.13  ? 29   PRO B CB  1 
ATOM   1456 C  CG  . PRO B 1 29  ? 168.235 189.844 177.090 1.00 2.13  ? 29   PRO B CG  1 
ATOM   1457 C  CD  . PRO B 1 29  ? 168.961 188.652 177.647 1.00 2.13  ? 29   PRO B CD  1 
ATOM   1458 N  N   . GLN B 1 30  ? 170.023 187.725 173.973 1.00 1.71  ? 30   GLN B N   1 
ATOM   1459 C  CA  . GLN B 1 30  ? 170.662 187.116 172.810 1.00 1.71  ? 30   GLN B CA  1 
ATOM   1460 C  C   . GLN B 1 30  ? 170.052 185.758 172.498 1.00 1.71  ? 30   GLN B C   1 
ATOM   1461 O  O   . GLN B 1 30  ? 169.507 185.545 171.409 1.00 1.71  ? 30   GLN B O   1 
ATOM   1462 C  CB  . GLN B 1 30  ? 172.168 186.989 173.060 1.00 1.71  ? 30   GLN B CB  1 
ATOM   1463 C  CG  . GLN B 1 30  ? 172.936 186.116 172.069 1.00 1.71  ? 30   GLN B CG  1 
ATOM   1464 C  CD  . GLN B 1 30  ? 172.855 186.585 170.641 1.00 1.71  ? 30   GLN B CD  1 
ATOM   1465 O  OE1 . GLN B 1 30  ? 172.737 187.774 170.371 1.00 1.71  ? 30   GLN B OE1 1 
ATOM   1466 N  NE2 . GLN B 1 30  ? 172.923 185.642 169.710 1.00 1.71  ? 30   GLN B NE2 1 
ATOM   1467 N  N   . SER B 1 31  ? 170.128 184.828 173.450 1.00 1.85  ? 31   SER B N   1 
ATOM   1468 C  CA  . SER B 1 31  ? 169.669 183.470 173.192 1.00 1.85  ? 31   SER B CA  1 
ATOM   1469 C  C   . SER B 1 31  ? 168.184 183.442 172.867 1.00 1.85  ? 31   SER B C   1 
ATOM   1470 O  O   . SER B 1 31  ? 167.748 182.691 171.990 1.00 1.85  ? 31   SER B O   1 
ATOM   1471 C  CB  . SER B 1 31  ? 169.961 182.582 174.398 1.00 1.85  ? 31   SER B CB  1 
ATOM   1472 O  OG  . SER B 1 31  ? 169.200 182.991 175.519 1.00 1.85  ? 31   SER B OG  1 
ATOM   1473 N  N   . LEU B 1 32  ? 167.390 184.258 173.559 1.00 1.43  ? 32   LEU B N   1 
ATOM   1474 C  CA  . LEU B 1 32  ? 165.943 184.176 173.404 1.00 1.43  ? 32   LEU B CA  1 
ATOM   1475 C  C   . LEU B 1 32  ? 165.498 184.708 172.048 1.00 1.43  ? 32   LEU B C   1 
ATOM   1476 O  O   . LEU B 1 32  ? 164.679 184.077 171.366 1.00 1.43  ? 32   LEU B O   1 
ATOM   1477 C  CB  . LEU B 1 32  ? 165.258 184.931 174.539 1.00 1.43  ? 32   LEU B CB  1 
ATOM   1478 C  CG  . LEU B 1 32  ? 163.930 184.344 175.013 1.00 1.43  ? 32   LEU B CG  1 
ATOM   1479 C  CD1 . LEU B 1 32  ? 164.145 182.957 175.583 1.00 1.43  ? 32   LEU B CD1 1 
ATOM   1480 C  CD2 . LEU B 1 32  ? 163.283 185.238 176.052 1.00 1.43  ? 32   LEU B CD2 1 
ATOM   1481 N  N   . ASP B 1 33  ? 166.028 185.857 171.622 1.00 1.27  ? 33   ASP B N   1 
ATOM   1482 C  CA  . ASP B 1 33  ? 165.638 186.350 170.308 1.00 1.27  ? 33   ASP B CA  1 
ATOM   1483 C  C   . ASP B 1 33  ? 166.248 185.499 169.206 1.00 1.27  ? 33   ASP B C   1 
ATOM   1484 O  O   . ASP B 1 33  ? 165.651 185.365 168.135 1.00 1.27  ? 33   ASP B O   1 
ATOM   1485 C  CB  . ASP B 1 33  ? 166.012 187.825 170.125 1.00 1.27  ? 33   ASP B CB  1 
ATOM   1486 C  CG  . ASP B 1 33  ? 167.482 188.040 169.845 1.00 1.27  ? 33   ASP B CG  1 
ATOM   1487 O  OD1 . ASP B 1 33  ? 168.262 187.069 169.872 1.00 1.27  ? 33   ASP B OD1 1 
ATOM   1488 O  OD2 . ASP B 1 33  ? 167.859 189.197 169.570 1.00 1.27  ? 33   ASP B OD2 1 
ATOM   1489 N  N   . SER B 1 34  ? 167.415 184.894 169.447 1.00 1.22  ? 34   SER B N   1 
ATOM   1490 C  CA  . SER B 1 34  ? 167.939 183.941 168.477 1.00 1.22  ? 34   SER B CA  1 
ATOM   1491 C  C   . SER B 1 34  ? 167.009 182.749 168.337 1.00 1.22  ? 34   SER B C   1 
ATOM   1492 O  O   . SER B 1 34  ? 166.745 182.285 167.224 1.00 1.22  ? 34   SER B O   1 
ATOM   1493 C  CB  . SER B 1 34  ? 169.336 183.481 168.884 1.00 1.22  ? 34   SER B CB  1 
ATOM   1494 O  OG  . SER B 1 34  ? 170.253 184.558 168.865 1.00 1.22  ? 34   SER B OG  1 
ATOM   1495 N  N   . TRP B 1 35  ? 166.490 182.246 169.455 1.00 1.14  ? 35   TRP B N   1 
ATOM   1496 C  CA  . TRP B 1 35  ? 165.547 181.139 169.394 1.00 1.14  ? 35   TRP B CA  1 
ATOM   1497 C  C   . TRP B 1 35  ? 164.301 181.533 168.615 1.00 1.14  ? 35   TRP B C   1 
ATOM   1498 O  O   . TRP B 1 35  ? 163.839 180.787 167.745 1.00 1.14  ? 35   TRP B O   1 
ATOM   1499 C  CB  . TRP B 1 35  ? 165.170 180.692 170.802 1.00 1.14  ? 35   TRP B CB  1 
ATOM   1500 C  CG  . TRP B 1 35  ? 163.921 179.882 170.836 1.00 1.14  ? 35   TRP B CG  1 
ATOM   1501 C  CD1 . TRP B 1 35  ? 163.764 178.610 170.384 1.00 1.14  ? 35   TRP B CD1 1 
ATOM   1502 C  CD2 . TRP B 1 35  ? 162.647 180.288 171.344 1.00 1.14  ? 35   TRP B CD2 1 
ATOM   1503 N  NE1 . TRP B 1 35  ? 162.472 178.194 170.581 1.00 1.14  ? 35   TRP B NE1 1 
ATOM   1504 C  CE2 . TRP B 1 35  ? 161.765 179.208 171.168 1.00 1.14  ? 35   TRP B CE2 1 
ATOM   1505 C  CE3 . TRP B 1 35  ? 162.166 181.461 171.930 1.00 1.14  ? 35   TRP B CE3 1 
ATOM   1506 C  CZ2 . TRP B 1 35  ? 160.431 179.263 171.557 1.00 1.14  ? 35   TRP B CZ2 1 
ATOM   1507 C  CZ3 . TRP B 1 35  ? 160.841 181.514 172.316 1.00 1.14  ? 35   TRP B CZ3 1 
ATOM   1508 C  CH2 . TRP B 1 35  ? 159.989 180.423 172.127 1.00 1.14  ? 35   TRP B CH2 1 
ATOM   1509 N  N   . TRP B 1 36  ? 163.740 182.706 168.910 1.00 1.10  ? 36   TRP B N   1 
ATOM   1510 C  CA  . TRP B 1 36  ? 162.509 183.085 168.224 1.00 1.10  ? 36   TRP B CA  1 
ATOM   1511 C  C   . TRP B 1 36  ? 162.759 183.286 166.736 1.00 1.10  ? 36   TRP B C   1 
ATOM   1512 O  O   . TRP B 1 36  ? 161.937 182.890 165.904 1.00 1.10  ? 36   TRP B O   1 
ATOM   1513 C  CB  . TRP B 1 36  ? 161.903 184.347 168.826 1.00 1.10  ? 36   TRP B CB  1 
ATOM   1514 C  CG  . TRP B 1 36  ? 160.431 184.433 168.545 1.00 1.10  ? 36   TRP B CG  1 
ATOM   1515 C  CD1 . TRP B 1 36  ? 159.426 183.893 169.295 1.00 1.10  ? 36   TRP B CD1 1 
ATOM   1516 C  CD2 . TRP B 1 36  ? 159.800 185.047 167.418 1.00 1.10  ? 36   TRP B CD2 1 
ATOM   1517 N  NE1 . TRP B 1 36  ? 158.210 184.156 168.719 1.00 1.10  ? 36   TRP B NE1 1 
ATOM   1518 C  CE2 . TRP B 1 36  ? 158.412 184.861 167.563 1.00 1.10  ? 36   TRP B CE2 1 
ATOM   1519 C  CE3 . TRP B 1 36  ? 160.272 185.744 166.305 1.00 1.10  ? 36   TRP B CE3 1 
ATOM   1520 C  CZ2 . TRP B 1 36  ? 157.495 185.350 166.642 1.00 1.10  ? 36   TRP B CZ2 1 
ATOM   1521 C  CZ3 . TRP B 1 36  ? 159.358 186.226 165.390 1.00 1.10  ? 36   TRP B CZ3 1 
ATOM   1522 C  CH2 . TRP B 1 36  ? 157.987 186.029 165.565 1.00 1.10  ? 36   TRP B CH2 1 
ATOM   1523 N  N   . THR B 1 37  ? 163.887 183.900 166.375 1.00 0.97  ? 37   THR B N   1 
ATOM   1524 C  CA  . THR B 1 37  ? 164.220 184.045 164.964 1.00 0.97  ? 37   THR B CA  1 
ATOM   1525 C  C   . THR B 1 37  ? 164.418 182.685 164.313 1.00 0.97  ? 37   THR B C   1 
ATOM   1526 O  O   . THR B 1 37  ? 164.158 182.516 163.117 1.00 0.97  ? 37   THR B O   1 
ATOM   1527 C  CB  . THR B 1 37  ? 165.473 184.901 164.803 1.00 0.97  ? 37   THR B CB  1 
ATOM   1528 O  OG1 . THR B 1 37  ? 165.161 186.268 165.092 1.00 0.97  ? 37   THR B OG1 1 
ATOM   1529 C  CG2 . THR B 1 37  ? 166.009 184.802 163.389 1.00 0.97  ? 37   THR B CG2 1 
ATOM   1530 N  N   . SER B 1 38  ? 164.896 181.704 165.079 1.00 1.26  ? 38   SER B N   1 
ATOM   1531 C  CA  . SER B 1 38  ? 164.947 180.338 164.575 1.00 1.26  ? 38   SER B CA  1 
ATOM   1532 C  C   . SER B 1 38  ? 163.546 179.810 164.304 1.00 1.26  ? 38   SER B C   1 
ATOM   1533 O  O   . SER B 1 38  ? 163.315 179.123 163.304 1.00 1.26  ? 38   SER B O   1 
ATOM   1534 C  CB  . SER B 1 38  ? 165.677 179.440 165.569 1.00 1.26  ? 38   SER B CB  1 
ATOM   1535 O  OG  . SER B 1 38  ? 165.718 178.105 165.107 1.00 1.26  ? 38   SER B OG  1 
ATOM   1536 N  N   . LEU B 1 39  ? 162.597 180.120 165.187 1.00 1.14  ? 39   LEU B N   1 
ATOM   1537 C  CA  . LEU B 1 39  ? 161.219 179.700 164.959 1.00 1.14  ? 39   LEU B CA  1 
ATOM   1538 C  C   . LEU B 1 39  ? 160.688 180.219 163.631 1.00 1.14  ? 39   LEU B C   1 
ATOM   1539 O  O   . LEU B 1 39  ? 159.926 179.522 162.955 1.00 1.14  ? 39   LEU B O   1 
ATOM   1540 C  CB  . LEU B 1 39  ? 160.329 180.175 166.105 1.00 1.14  ? 39   LEU B CB  1 
ATOM   1541 C  CG  . LEU B 1 39  ? 159.958 179.115 167.135 1.00 1.14  ? 39   LEU B CG  1 
ATOM   1542 C  CD1 . LEU B 1 39  ? 161.192 178.583 167.814 1.00 1.14  ? 39   LEU B CD1 1 
ATOM   1543 C  CD2 . LEU B 1 39  ? 159.010 179.698 168.156 1.00 1.14  ? 39   LEU B CD2 1 
ATOM   1544 N  N   . ASN B 1 40  ? 161.105 181.418 163.230 1.00 1.20  ? 40   ASN B N   1 
ATOM   1545 C  CA  . ASN B 1 40  ? 160.668 181.994 161.956 1.00 1.20  ? 40   ASN B CA  1 
ATOM   1546 C  C   . ASN B 1 40  ? 160.954 181.043 160.795 1.00 1.20  ? 40   ASN B C   1 
ATOM   1547 O  O   . ASN B 1 40  ? 160.192 180.966 159.831 1.00 1.20  ? 40   ASN B O   1 
ATOM   1548 C  CB  . ASN B 1 40  ? 161.371 183.329 161.704 1.00 1.20  ? 40   ASN B CB  1 
ATOM   1549 C  CG  . ASN B 1 40  ? 160.693 184.487 162.404 1.00 1.20  ? 40   ASN B CG  1 
ATOM   1550 O  OD1 . ASN B 1 40  ? 159.507 184.423 162.728 1.00 1.20  ? 40   ASN B OD1 1 
ATOM   1551 N  ND2 . ASN B 1 40  ? 161.442 185.559 162.635 1.00 1.20  ? 40   ASN B ND2 1 
ATOM   1552 N  N   . PHE B 1 41  ? 162.065 180.324 160.906 1.00 1.48  ? 41   PHE B N   1 
ATOM   1553 C  CA  . PHE B 1 41  ? 162.496 179.360 159.908 1.00 1.48  ? 41   PHE B CA  1 
ATOM   1554 C  C   . PHE B 1 41  ? 162.343 177.958 160.480 1.00 1.48  ? 41   PHE B C   1 
ATOM   1555 O  O   . PHE B 1 41  ? 161.897 177.769 161.612 1.00 1.48  ? 41   PHE B O   1 
ATOM   1556 C  CB  . PHE B 1 41  ? 163.936 179.643 159.485 1.00 1.48  ? 41   PHE B CB  1 
ATOM   1557 C  CG  . PHE B 1 41  ? 164.192 181.085 159.198 1.00 1.48  ? 41   PHE B CG  1 
ATOM   1558 C  CD1 . PHE B 1 41  ? 163.625 181.691 158.093 1.00 1.48  ? 41   PHE B CD1 1 
ATOM   1559 C  CD2 . PHE B 1 41  ? 164.960 181.848 160.051 1.00 1.48  ? 41   PHE B CD2 1 
ATOM   1560 C  CE1 . PHE B 1 41  ? 163.846 183.021 157.830 1.00 1.48  ? 41   PHE B CE1 1 
ATOM   1561 C  CE2 . PHE B 1 41  ? 165.179 183.182 159.794 1.00 1.48  ? 41   PHE B CE2 1 
ATOM   1562 C  CZ  . PHE B 1 41  ? 164.622 183.767 158.681 1.00 1.48  ? 41   PHE B CZ  1 
ATOM   1563 N  N   . LEU B 1 42  ? 162.724 176.962 159.690 1.00 2.35  ? 42   LEU B N   1 
ATOM   1564 C  CA  . LEU B 1 42  ? 162.506 175.585 160.105 1.00 2.35  ? 42   LEU B CA  1 
ATOM   1565 C  C   . LEU B 1 42  ? 163.539 175.186 161.151 1.00 2.35  ? 42   LEU B C   1 
ATOM   1566 O  O   . LEU B 1 42  ? 164.292 174.226 160.961 1.00 2.35  ? 42   LEU B O   1 
ATOM   1567 C  CB  . LEU B 1 42  ? 162.557 174.659 158.889 1.00 2.35  ? 42   LEU B CB  1 
ATOM   1568 C  CG  . LEU B 1 42  ? 161.222 174.534 158.155 1.00 2.35  ? 42   LEU B CG  1 
ATOM   1569 C  CD1 . LEU B 1 42  ? 160.782 175.887 157.623 1.00 2.35  ? 42   LEU B CD1 1 
ATOM   1570 C  CD2 . LEU B 1 42  ? 161.317 173.518 157.032 1.00 2.35  ? 42   LEU B CD2 1 
ATOM   1571 N  N   . GLY B 1 43  ? 163.571 175.914 162.265 1.00 1.97  ? 43   GLY B N   1 
ATOM   1572 C  CA  . GLY B 1 43  ? 164.517 175.629 163.322 1.00 1.97  ? 43   GLY B CA  1 
ATOM   1573 C  C   . GLY B 1 43  ? 165.930 176.094 163.061 1.00 1.97  ? 43   GLY B C   1 
ATOM   1574 O  O   . GLY B 1 43  ? 166.829 175.760 163.839 1.00 1.97  ? 43   GLY B O   1 
ATOM   1575 N  N   . GLY B 1 44  ? 166.159 176.863 161.998 1.00 1.87  ? 44   GLY B N   1 
ATOM   1576 C  CA  . GLY B 1 44  ? 167.502 177.283 161.644 1.00 1.87  ? 44   GLY B CA  1 
ATOM   1577 C  C   . GLY B 1 44  ? 167.615 178.766 161.363 1.00 1.87  ? 44   GLY B C   1 
ATOM   1578 O  O   . GLY B 1 44  ? 166.712 179.368 160.780 1.00 1.87  ? 44   GLY B O   1 
ATOM   1579 N  N   . THR B 1 45  ? 168.734 179.364 161.755 1.00 1.41  ? 45   THR B N   1 
ATOM   1580 C  CA  . THR B 1 45  ? 168.902 180.802 161.650 1.00 1.41  ? 45   THR B CA  1 
ATOM   1581 C  C   . THR B 1 45  ? 169.086 181.226 160.193 1.00 1.41  ? 45   THR B C   1 
ATOM   1582 O  O   . THR B 1 45  ? 169.047 180.415 159.265 1.00 1.41  ? 45   THR B O   1 
ATOM   1583 C  CB  . THR B 1 45  ? 170.093 181.259 162.488 1.00 1.41  ? 45   THR B CB  1 
ATOM   1584 O  OG1 . THR B 1 45  ? 171.290 180.638 162.002 1.00 1.41  ? 45   THR B OG1 1 
ATOM   1585 C  CG2 . THR B 1 45  ? 169.888 180.892 163.951 1.00 1.41  ? 45   THR B CG2 1 
ATOM   1586 N  N   . THR B 1 46  ? 169.283 182.527 160.006 1.00 1.36  ? 46   THR B N   1 
ATOM   1587 C  CA  . THR B 1 46  ? 169.420 183.151 158.698 1.00 1.36  ? 46   THR B CA  1 
ATOM   1588 C  C   . THR B 1 46  ? 170.608 184.112 158.708 1.00 1.36  ? 46   THR B C   1 
ATOM   1589 O  O   . THR B 1 46  ? 171.427 184.114 159.630 1.00 1.36  ? 46   THR B O   1 
ATOM   1590 C  CB  . THR B 1 46  ? 168.132 183.875 158.307 1.00 1.36  ? 46   THR B CB  1 
ATOM   1591 O  OG1 . THR B 1 46  ? 168.262 184.406 156.983 1.00 1.36  ? 46   THR B OG1 1 
ATOM   1592 C  CG2 . THR B 1 46  ? 167.837 185.006 159.279 1.00 1.36  ? 46   THR B CG2 1 
ATOM   1593 N  N   . VAL B 1 47  ? 170.702 184.923 157.658 1.00 1.48  ? 47   VAL B N   1 
ATOM   1594 C  CA  . VAL B 1 47  ? 171.762 185.910 157.504 1.00 1.48  ? 47   VAL B CA  1 
ATOM   1595 C  C   . VAL B 1 47  ? 171.130 187.285 157.351 1.00 1.48  ? 47   VAL B C   1 
ATOM   1596 O  O   . VAL B 1 47  ? 170.212 187.472 156.545 1.00 1.48  ? 47   VAL B O   1 
ATOM   1597 C  CB  . VAL B 1 47  ? 172.661 185.581 156.297 1.00 1.48  ? 47   VAL B CB  1 
ATOM   1598 C  CG1 . VAL B 1 47  ? 173.342 184.237 156.499 1.00 1.48  ? 47   VAL B CG1 1 
ATOM   1599 C  CG2 . VAL B 1 47  ? 171.855 185.588 155.004 1.00 1.48  ? 47   VAL B CG2 1 
ATOM   1600 N  N   . CYS B 1 48  ? 171.624 188.246 158.125 1.00 1.71  ? 48   CYS B N   1 
ATOM   1601 C  CA  . CYS B 1 48  ? 171.113 189.611 158.092 1.00 1.71  ? 48   CYS B CA  1 
ATOM   1602 C  C   . CYS B 1 48  ? 171.379 190.185 156.706 1.00 1.71  ? 48   CYS B C   1 
ATOM   1603 O  O   . CYS B 1 48  ? 172.459 189.987 156.143 1.00 1.71  ? 48   CYS B O   1 
ATOM   1604 C  CB  . CYS B 1 48  ? 171.767 190.462 159.174 1.00 1.71  ? 48   CYS B CB  1 
ATOM   1605 S  SG  . CYS B 1 48  ? 171.313 192.200 159.111 1.00 1.71  ? 48   CYS B SG  1 
ATOM   1606 N  N   . LEU B 1 49  ? 170.396 190.898 156.162 1.00 2.84  ? 49   LEU B N   1 
ATOM   1607 C  CA  . LEU B 1 49  ? 170.447 191.353 154.778 1.00 2.84  ? 49   LEU B CA  1 
ATOM   1608 C  C   . LEU B 1 49  ? 171.756 192.065 154.463 1.00 2.84  ? 49   LEU B C   1 
ATOM   1609 O  O   . LEU B 1 49  ? 172.412 191.749 153.465 1.00 2.84  ? 49   LEU B O   1 
ATOM   1610 C  CB  . LEU B 1 49  ? 169.261 192.272 154.483 1.00 2.84  ? 49   LEU B CB  1 
ATOM   1611 C  CG  . LEU B 1 49  ? 167.888 191.604 154.590 1.00 2.84  ? 49   LEU B CG  1 
ATOM   1612 C  CD1 . LEU B 1 49  ? 166.776 192.644 154.571 1.00 2.84  ? 49   LEU B CD1 1 
ATOM   1613 C  CD2 . LEU B 1 49  ? 167.688 190.580 153.484 1.00 2.84  ? 49   LEU B CD2 1 
ATOM   1614 N  N   . GLY B 1 50  ? 172.149 193.021 155.299 1.00 2.84  ? 50   GLY B N   1 
ATOM   1615 C  CA  . GLY B 1 50  ? 173.380 193.757 155.075 1.00 2.84  ? 50   GLY B CA  1 
ATOM   1616 C  C   . GLY B 1 50  ? 173.439 195.057 155.847 1.00 2.84  ? 50   GLY B C   1 
ATOM   1617 O  O   . GLY B 1 50  ? 173.182 195.078 157.047 1.00 2.84  ? 50   GLY B O   1 
ATOM   1618 N  N   . SER B 1 58  ? 180.941 189.006 154.619 1.00 2.84  ? 58   SER B N   1 
ATOM   1619 C  CA  . SER B 1 58  ? 180.448 188.885 155.985 1.00 2.84  ? 58   SER B CA  1 
ATOM   1620 C  C   . SER B 1 58  ? 178.931 188.743 156.005 1.00 2.84  ? 58   SER B C   1 
ATOM   1621 O  O   . SER B 1 58  ? 178.204 189.705 155.755 1.00 2.84  ? 58   SER B O   1 
ATOM   1622 C  CB  . SER B 1 58  ? 180.869 190.096 156.816 1.00 2.84  ? 58   SER B CB  1 
ATOM   1623 O  OG  . SER B 1 58  ? 180.508 191.305 156.172 1.00 2.84  ? 58   SER B OG  1 
ATOM   1624 N  N   . ASN B 1 59  ? 178.434 187.520 156.270 1.00 2.84  ? 59   ASN B N   1 
ATOM   1625 C  CA  . ASN B 1 59  ? 177.010 187.239 156.369 1.00 2.84  ? 59   ASN B CA  1 
ATOM   1626 C  C   . ASN B 1 59  ? 176.722 186.832 157.827 1.00 2.84  ? 59   ASN B C   1 
ATOM   1627 O  O   . ASN B 1 59  ? 176.895 185.670 158.196 1.00 2.84  ? 59   ASN B O   1 
ATOM   1628 C  CB  . ASN B 1 59  ? 176.634 186.097 155.429 1.00 2.84  ? 59   ASN B CB  1 
ATOM   1629 C  CG  . ASN B 1 59  ? 176.847 186.449 153.970 1.00 2.84  ? 59   ASN B CG  1 
ATOM   1630 O  OD1 . ASN B 1 59  ? 177.441 185.679 153.214 1.00 2.84  ? 59   ASN B OD1 1 
ATOM   1631 N  ND2 . ASN B 1 59  ? 176.363 187.617 153.566 1.00 2.84  ? 59   ASN B ND2 1 
ATOM   1632 N  N   . HIS B 1 60  ? 176.285 187.787 158.645 1.00 1.72  ? 60   HIS B N   1 
ATOM   1633 C  CA  . HIS B 1 60  ? 176.001 187.571 160.053 1.00 1.72  ? 60   HIS B CA  1 
ATOM   1634 C  C   . HIS B 1 60  ? 174.507 187.382 160.272 1.00 1.72  ? 60   HIS B C   1 
ATOM   1635 O  O   . HIS B 1 60  ? 173.677 188.001 159.602 1.00 1.72  ? 60   HIS B O   1 
ATOM   1636 C  CB  . HIS B 1 60  ? 176.497 188.750 160.889 1.00 1.72  ? 60   HIS B CB  1 
ATOM   1637 C  CG  . HIS B 1 60  ? 176.030 190.080 160.387 1.00 1.72  ? 60   HIS B CG  1 
ATOM   1638 N  ND1 . HIS B 1 60  ? 176.683 190.766 159.387 1.00 1.72  ? 60   HIS B ND1 1 
ATOM   1639 C  CD2 . HIS B 1 60  ? 174.970 190.845 160.738 1.00 1.72  ? 60   HIS B CD2 1 
ATOM   1640 C  CE1 . HIS B 1 60  ? 176.050 191.901 159.148 1.00 1.72  ? 60   HIS B CE1 1 
ATOM   1641 N  NE2 . HIS B 1 60  ? 175.008 191.974 159.956 1.00 1.72  ? 60   HIS B NE2 1 
ATOM   1642 N  N   . SER B 1 61  ? 174.172 186.514 161.221 1.00 1.25  ? 61   SER B N   1 
ATOM   1643 C  CA  . SER B 1 61  ? 172.787 186.322 161.594 1.00 1.25  ? 61   SER B CA  1 
ATOM   1644 C  C   . SER B 1 61  ? 172.227 187.617 162.173 1.00 1.25  ? 61   SER B C   1 
ATOM   1645 O  O   . SER B 1 61  ? 172.926 188.338 162.886 1.00 1.25  ? 61   SER B O   1 
ATOM   1646 C  CB  . SER B 1 61  ? 172.668 185.195 162.614 1.00 1.25  ? 61   SER B CB  1 
ATOM   1647 O  OG  . SER B 1 61  ? 171.330 185.033 163.045 1.00 1.25  ? 61   SER B OG  1 
ATOM   1648 N  N   . PRO B 1 62  ? 170.963 187.940 161.888 1.00 1.08  ? 62   PRO B N   1 
ATOM   1649 C  CA  . PRO B 1 62  ? 170.391 189.179 162.421 1.00 1.08  ? 62   PRO B CA  1 
ATOM   1650 C  C   . PRO B 1 62  ? 170.201 189.158 163.924 1.00 1.08  ? 62   PRO B C   1 
ATOM   1651 O  O   . PRO B 1 62  ? 169.869 190.196 164.505 1.00 1.08  ? 62   PRO B O   1 
ATOM   1652 C  CB  . PRO B 1 62  ? 169.039 189.293 161.698 1.00 1.08  ? 62   PRO B CB  1 
ATOM   1653 C  CG  . PRO B 1 62  ? 168.864 188.053 160.908 1.00 1.08  ? 62   PRO B CG  1 
ATOM   1654 C  CD  . PRO B 1 62  ? 169.938 187.092 161.263 1.00 1.08  ? 62   PRO B CD  1 
ATOM   1655 N  N   . THR B 1 63  ? 170.387 188.006 164.560 1.00 1.23  ? 63   THR B N   1 
ATOM   1656 C  CA  . THR B 1 63  ? 170.302 187.934 166.010 1.00 1.23  ? 63   THR B CA  1 
ATOM   1657 C  C   . THR B 1 63  ? 171.585 188.414 166.667 1.00 1.23  ? 63   THR B C   1 
ATOM   1658 O  O   . THR B 1 63  ? 171.580 188.747 167.856 1.00 1.23  ? 63   THR B O   1 
ATOM   1659 C  CB  . THR B 1 63  ? 169.997 186.505 166.444 1.00 1.23  ? 63   THR B CB  1 
ATOM   1660 O  OG1 . THR B 1 63  ? 171.093 185.653 166.094 1.00 1.23  ? 63   THR B OG1 1 
ATOM   1661 C  CG2 . THR B 1 63  ? 168.735 186.003 165.757 1.00 1.23  ? 63   THR B CG2 1 
ATOM   1662 N  N   . SER B 1 64  ? 172.688 188.445 165.920 1.00 1.15  ? 64   SER B N   1 
ATOM   1663 C  CA  . SER B 1 64  ? 173.956 188.948 166.441 1.00 1.15  ? 64   SER B CA  1 
ATOM   1664 C  C   . SER B 1 64  ? 174.695 189.612 165.283 1.00 1.15  ? 64   SER B C   1 
ATOM   1665 O  O   . SER B 1 64  ? 175.419 188.940 164.543 1.00 1.15  ? 64   SER B O   1 
ATOM   1666 C  CB  . SER B 1 64  ? 174.778 187.827 167.057 1.00 1.15  ? 64   SER B CB  1 
ATOM   1667 O  OG  . SER B 1 64  ? 175.092 186.844 166.088 1.00 1.15  ? 64   SER B OG  1 
ATOM   1668 N  N   . CYS B 1 65  ? 174.512 190.918 165.135 1.00 1.25  ? 65   CYS B N   1 
ATOM   1669 C  CA  . CYS B 1 65  ? 175.199 191.679 164.109 1.00 1.25  ? 65   CYS B CA  1 
ATOM   1670 C  C   . CYS B 1 65  ? 176.422 192.373 164.685 1.00 1.25  ? 65   CYS B C   1 
ATOM   1671 O  O   . CYS B 1 65  ? 176.482 192.660 165.883 1.00 1.25  ? 65   CYS B O   1 
ATOM   1672 C  CB  . CYS B 1 65  ? 174.266 192.728 163.490 1.00 1.25  ? 65   CYS B CB  1 
ATOM   1673 S  SG  . CYS B 1 65  ? 172.717 192.109 162.804 1.00 1.25  ? 65   CYS B SG  1 
ATOM   1674 N  N   . PRO B 1 66  ? 177.433 192.648 163.858 1.00 1.33  ? 66   PRO B N   1 
ATOM   1675 C  CA  . PRO B 1 66  ? 178.540 193.473 164.323 1.00 1.33  ? 66   PRO B CA  1 
ATOM   1676 C  C   . PRO B 1 66  ? 178.099 194.915 164.482 1.00 1.33  ? 66   PRO B C   1 
ATOM   1677 O  O   . PRO B 1 66  ? 177.131 195.356 163.838 1.00 1.33  ? 66   PRO B O   1 
ATOM   1678 C  CB  . PRO B 1 66  ? 179.587 193.321 163.205 1.00 1.33  ? 66   PRO B CB  1 
ATOM   1679 C  CG  . PRO B 1 66  ? 178.795 193.020 161.996 1.00 1.33  ? 66   PRO B CG  1 
ATOM   1680 C  CD  . PRO B 1 66  ? 177.617 192.216 162.462 1.00 1.33  ? 66   PRO B CD  1 
ATOM   1681 N  N   . PRO B 1 67  ? 178.779 195.693 165.325 1.00 1.70  ? 67   PRO B N   1 
ATOM   1682 C  CA  . PRO B 1 67  ? 178.315 197.066 165.582 1.00 1.70  ? 67   PRO B CA  1 
ATOM   1683 C  C   . PRO B 1 67  ? 178.176 197.912 164.331 1.00 1.70  ? 67   PRO B C   1 
ATOM   1684 O  O   . PRO B 1 67  ? 177.306 198.791 164.284 1.00 1.70  ? 67   PRO B O   1 
ATOM   1685 C  CB  . PRO B 1 67  ? 179.387 197.635 166.521 1.00 1.70  ? 67   PRO B CB  1 
ATOM   1686 C  CG  . PRO B 1 67  ? 180.076 196.466 167.113 1.00 1.70  ? 67   PRO B CG  1 
ATOM   1687 C  CD  . PRO B 1 67  ? 179.873 195.283 166.221 1.00 1.70  ? 67   PRO B CD  1 
ATOM   1688 N  N   . THR B 1 68  ? 179.012 197.688 163.316 1.00 1.42  ? 68   THR B N   1 
ATOM   1689 C  CA  . THR B 1 68  ? 178.921 198.491 162.101 1.00 1.42  ? 68   THR B CA  1 
ATOM   1690 C  C   . THR B 1 68  ? 177.670 198.157 161.298 1.00 1.42  ? 68   THR B C   1 
ATOM   1691 O  O   . THR B 1 68  ? 177.120 199.031 160.619 1.00 1.42  ? 68   THR B O   1 
ATOM   1692 C  CB  . THR B 1 68  ? 180.165 198.286 161.240 1.00 1.42  ? 68   THR B CB  1 
ATOM   1693 O  OG1 . THR B 1 68  ? 180.147 199.207 160.143 1.00 1.42  ? 68   THR B OG1 1 
ATOM   1694 C  CG2 . THR B 1 68  ? 180.220 196.866 160.702 1.00 1.42  ? 68   THR B CG2 1 
ATOM   1695 N  N   . CYS B 1 69  ? 177.207 196.915 161.369 1.00 1.49  ? 69   CYS B N   1 
ATOM   1696 C  CA  . CYS B 1 69  ? 176.053 196.494 160.588 1.00 1.49  ? 69   CYS B CA  1 
ATOM   1697 C  C   . CYS B 1 69  ? 174.843 197.356 160.936 1.00 1.49  ? 69   CYS B C   1 
ATOM   1698 O  O   . CYS B 1 69  ? 174.547 197.545 162.123 1.00 1.49  ? 69   CYS B O   1 
ATOM   1699 C  CB  . CYS B 1 69  ? 175.755 195.023 160.869 1.00 1.49  ? 69   CYS B CB  1 
ATOM   1700 S  SG  . CYS B 1 69  ? 174.384 194.316 159.937 1.00 1.49  ? 69   CYS B SG  1 
ATOM   1701 N  N   . PRO B 1 70  ? 174.127 197.902 159.948 1.00 1.21  ? 70   PRO B N   1 
ATOM   1702 C  CA  . PRO B 1 70  ? 172.959 198.729 160.291 1.00 1.21  ? 70   PRO B CA  1 
ATOM   1703 C  C   . PRO B 1 70  ? 171.936 197.980 161.116 1.00 1.21  ? 70   PRO B C   1 
ATOM   1704 O  O   . PRO B 1 70  ? 171.437 198.507 162.121 1.00 1.21  ? 70   PRO B O   1 
ATOM   1705 C  CB  . PRO B 1 70  ? 172.402 199.141 158.922 1.00 1.21  ? 70   PRO B CB  1 
ATOM   1706 C  CG  . PRO B 1 70  ? 172.929 198.147 157.967 1.00 1.21  ? 70   PRO B CG  1 
ATOM   1707 C  CD  . PRO B 1 70  ? 174.248 197.691 158.497 1.00 1.21  ? 70   PRO B CD  1 
ATOM   1708 N  N   . GLY B 1 71  ? 171.648 196.732 160.747 1.00 1.44  ? 71   GLY B N   1 
ATOM   1709 C  CA  . GLY B 1 71  ? 170.709 195.936 161.511 1.00 1.44  ? 71   GLY B CA  1 
ATOM   1710 C  C   . GLY B 1 71  ? 171.039 195.884 162.984 1.00 1.44  ? 71   GLY B C   1 
ATOM   1711 O  O   . GLY B 1 71  ? 170.139 195.678 163.805 1.00 1.44  ? 71   GLY B O   1 
ATOM   1712 N  N   . TYR B 1 72  ? 172.306 196.093 163.342 1.00 1.72  ? 72   TYR B N   1 
ATOM   1713 C  CA  . TYR B 1 72  ? 172.681 196.088 164.748 1.00 1.72  ? 72   TYR B CA  1 
ATOM   1714 C  C   . TYR B 1 72  ? 171.767 196.995 165.554 1.00 1.72  ? 72   TYR B C   1 
ATOM   1715 O  O   . TYR B 1 72  ? 171.263 196.598 166.611 1.00 1.72  ? 72   TYR B O   1 
ATOM   1716 C  CB  . TYR B 1 72  ? 174.137 196.522 164.906 1.00 1.72  ? 72   TYR B CB  1 
ATOM   1717 C  CG  . TYR B 1 72  ? 174.631 196.459 166.329 1.00 1.72  ? 72   TYR B CG  1 
ATOM   1718 C  CD1 . TYR B 1 72  ? 174.462 197.531 167.189 1.00 1.72  ? 72   TYR B CD1 1 
ATOM   1719 C  CD2 . TYR B 1 72  ? 175.255 195.324 166.815 1.00 1.72  ? 72   TYR B CD2 1 
ATOM   1720 C  CE1 . TYR B 1 72  ? 174.910 197.476 168.488 1.00 1.72  ? 72   TYR B CE1 1 
ATOM   1721 C  CE2 . TYR B 1 72  ? 175.705 195.259 168.115 1.00 1.72  ? 72   TYR B CE2 1 
ATOM   1722 C  CZ  . TYR B 1 72  ? 175.528 196.336 168.947 1.00 1.72  ? 72   TYR B CZ  1 
ATOM   1723 O  OH  . TYR B 1 72  ? 175.974 196.274 170.243 1.00 1.72  ? 72   TYR B OH  1 
ATOM   1724 N  N   . ARG B 1 73  ? 171.510 198.206 165.060 1.00 2.57  ? 73   ARG B N   1 
ATOM   1725 C  CA  . ARG B 1 73  ? 170.619 199.096 165.793 1.00 2.57  ? 73   ARG B CA  1 
ATOM   1726 C  C   . ARG B 1 73  ? 169.294 198.402 166.067 1.00 2.57  ? 73   ARG B C   1 
ATOM   1727 O  O   . ARG B 1 73  ? 168.875 198.267 167.223 1.00 2.57  ? 73   ARG B O   1 
ATOM   1728 C  CB  . ARG B 1 73  ? 170.404 200.386 165.006 1.00 2.57  ? 73   ARG B CB  1 
ATOM   1729 C  CG  . ARG B 1 73  ? 171.584 201.339 165.054 1.00 2.57  ? 73   ARG B CG  1 
ATOM   1730 C  CD  . ARG B 1 73  ? 171.695 202.030 166.402 1.00 2.57  ? 73   ARG B CD  1 
ATOM   1731 N  NE  . ARG B 1 73  ? 172.686 203.100 166.381 1.00 2.57  ? 73   ARG B NE  1 
ATOM   1732 C  CZ  . ARG B 1 73  ? 172.409 204.386 166.213 1.00 2.57  ? 73   ARG B CZ  1 
ATOM   1733 N  NH1 . ARG B 1 73  ? 171.168 204.813 166.041 1.00 2.57  ? 73   ARG B NH1 1 
ATOM   1734 N  NH2 . ARG B 1 73  ? 173.404 205.268 166.214 1.00 2.57  ? 73   ARG B NH2 1 
ATOM   1735 N  N   . TRP B 1 74  ? 168.660 197.883 165.014 1.00 1.04  ? 74   TRP B N   1 
ATOM   1736 C  CA  . TRP B 1 74  ? 167.422 197.136 165.188 1.00 1.04  ? 74   TRP B CA  1 
ATOM   1737 C  C   . TRP B 1 74  ? 167.607 196.036 166.221 1.00 1.04  ? 74   TRP B C   1 
ATOM   1738 O  O   . TRP B 1 74  ? 166.814 195.907 167.162 1.00 1.04  ? 74   TRP B O   1 
ATOM   1739 C  CB  . TRP B 1 74  ? 166.982 196.551 163.848 1.00 1.04  ? 74   TRP B CB  1 
ATOM   1740 C  CG  . TRP B 1 74  ? 166.322 197.547 162.956 1.00 1.04  ? 74   TRP B CG  1 
ATOM   1741 C  CD1 . TRP B 1 74  ? 166.755 197.958 161.735 1.00 1.04  ? 74   TRP B CD1 1 
ATOM   1742 C  CD2 . TRP B 1 74  ? 165.109 198.261 163.213 1.00 1.04  ? 74   TRP B CD2 1 
ATOM   1743 N  NE1 . TRP B 1 74  ? 165.889 198.882 161.210 1.00 1.04  ? 74   TRP B NE1 1 
ATOM   1744 C  CE2 . TRP B 1 74  ? 164.868 199.086 162.100 1.00 1.04  ? 74   TRP B CE2 1 
ATOM   1745 C  CE3 . TRP B 1 74  ? 164.202 198.283 164.275 1.00 1.04  ? 74   TRP B CE3 1 
ATOM   1746 C  CZ2 . TRP B 1 74  ? 163.761 199.922 162.018 1.00 1.04  ? 74   TRP B CZ2 1 
ATOM   1747 C  CZ3 . TRP B 1 74  ? 163.104 199.115 164.191 1.00 1.04  ? 74   TRP B CZ3 1 
ATOM   1748 C  CH2 . TRP B 1 74  ? 162.893 199.922 163.072 1.00 1.04  ? 74   TRP B CH2 1 
ATOM   1749 N  N   . MET B 1 75  ? 168.689 195.267 166.089 1.00 1.20  ? 75   MET B N   1 
ATOM   1750 C  CA  . MET B 1 75  ? 168.957 194.191 167.032 1.00 1.20  ? 75   MET B CA  1 
ATOM   1751 C  C   . MET B 1 75  ? 168.860 194.694 168.462 1.00 1.20  ? 75   MET B C   1 
ATOM   1752 O  O   . MET B 1 75  ? 168.155 194.107 169.289 1.00 1.20  ? 75   MET B O   1 
ATOM   1753 C  CB  . MET B 1 75  ? 170.336 193.597 166.746 1.00 1.20  ? 75   MET B CB  1 
ATOM   1754 C  CG  . MET B 1 75  ? 170.888 192.682 167.816 1.00 1.20  ? 75   MET B CG  1 
ATOM   1755 S  SD  . MET B 1 75  ? 172.577 192.205 167.420 1.00 1.20  ? 75   MET B SD  1 
ATOM   1756 C  CE  . MET B 1 75  ? 173.403 192.572 168.962 1.00 1.20  ? 75   MET B CE  1 
ATOM   1757 N  N   . CYS B 1 76  ? 169.516 195.817 168.761 1.00 1.14  ? 76   CYS B N   1 
ATOM   1758 C  CA  . CYS B 1 76  ? 169.463 196.335 170.122 1.00 1.14  ? 76   CYS B CA  1 
ATOM   1759 C  C   . CYS B 1 76  ? 168.020 196.541 170.556 1.00 1.14  ? 76   CYS B C   1 
ATOM   1760 O  O   . CYS B 1 76  ? 167.587 196.008 171.584 1.00 1.14  ? 76   CYS B O   1 
ATOM   1761 C  CB  . CYS B 1 76  ? 170.253 197.637 170.224 1.00 1.14  ? 76   CYS B CB  1 
ATOM   1762 S  SG  . CYS B 1 76  ? 172.028 197.422 170.028 1.00 1.14  ? 76   CYS B SG  1 
ATOM   1763 N  N   . LEU B 1 77  ? 167.242 197.263 169.746 1.00 1.31  ? 77   LEU B N   1 
ATOM   1764 C  CA  . LEU B 1 77  ? 165.830 197.437 170.057 1.00 1.31  ? 77   LEU B CA  1 
ATOM   1765 C  C   . LEU B 1 77  ? 165.190 196.088 170.322 1.00 1.31  ? 77   LEU B C   1 
ATOM   1766 O  O   . LEU B 1 77  ? 164.535 195.881 171.350 1.00 1.31  ? 77   LEU B O   1 
ATOM   1767 C  CB  . LEU B 1 77  ? 165.120 198.145 168.903 1.00 1.31  ? 77   LEU B CB  1 
ATOM   1768 C  CG  . LEU B 1 77  ? 163.589 198.157 168.945 1.00 1.31  ? 77   LEU B CG  1 
ATOM   1769 C  CD1 . LEU B 1 77  ? 163.090 199.117 170.003 1.00 1.31  ? 77   LEU B CD1 1 
ATOM   1770 C  CD2 . LEU B 1 77  ? 163.026 198.515 167.588 1.00 1.31  ? 77   LEU B CD2 1 
ATOM   1771 N  N   . ARG B 1 78  ? 165.409 195.144 169.413 1.00 0.69  ? 78   ARG B N   1 
ATOM   1772 C  CA  . ARG B 1 78  ? 164.863 193.808 169.587 1.00 0.69  ? 78   ARG B CA  1 
ATOM   1773 C  C   . ARG B 1 78  ? 165.303 193.224 170.923 1.00 0.69  ? 78   ARG B C   1 
ATOM   1774 O  O   . ARG B 1 78  ? 164.466 192.836 171.748 1.00 0.69  ? 78   ARG B O   1 
ATOM   1775 C  CB  . ARG B 1 78  ? 165.307 192.945 168.411 1.00 0.69  ? 78   ARG B CB  1 
ATOM   1776 C  CG  . ARG B 1 78  ? 164.722 191.571 168.367 1.00 0.69  ? 78   ARG B CG  1 
ATOM   1777 C  CD  . ARG B 1 78  ? 164.372 191.173 166.943 1.00 0.69  ? 78   ARG B CD  1 
ATOM   1778 N  NE  . ARG B 1 78  ? 165.325 191.689 165.969 1.00 0.69  ? 78   ARG B NE  1 
ATOM   1779 C  CZ  . ARG B 1 78  ? 166.595 191.318 165.889 1.00 0.69  ? 78   ARG B CZ  1 
ATOM   1780 N  NH1 . ARG B 1 78  ? 167.105 190.416 166.712 1.00 0.69  ? 78   ARG B NH1 1 
ATOM   1781 N  NH2 . ARG B 1 78  ? 167.372 191.864 164.961 1.00 0.69  ? 78   ARG B NH2 1 
ATOM   1782 N  N   . ARG B 1 79  ? 166.613 193.244 171.193 1.00 1.34  ? 79   ARG B N   1 
ATOM   1783 C  CA  . ARG B 1 79  ? 167.107 192.738 172.470 1.00 1.34  ? 79   ARG B CA  1 
ATOM   1784 C  C   . ARG B 1 79  ? 166.353 193.372 173.622 1.00 1.34  ? 79   ARG B C   1 
ATOM   1785 O  O   . ARG B 1 79  ? 166.014 192.701 174.603 1.00 1.34  ? 79   ARG B O   1 
ATOM   1786 C  CB  . ARG B 1 79  ? 168.595 193.041 172.629 1.00 1.34  ? 79   ARG B CB  1 
ATOM   1787 C  CG  . ARG B 1 79  ? 169.507 192.442 171.598 1.00 1.34  ? 79   ARG B CG  1 
ATOM   1788 C  CD  . ARG B 1 79  ? 169.599 190.952 171.699 1.00 1.34  ? 79   ARG B CD  1 
ATOM   1789 N  NE  . ARG B 1 79  ? 170.489 190.443 170.667 1.00 1.34  ? 79   ARG B NE  1 
ATOM   1790 C  CZ  . ARG B 1 79  ? 171.797 190.284 170.821 1.00 1.34  ? 79   ARG B CZ  1 
ATOM   1791 N  NH1 . ARG B 1 79  ? 172.401 190.579 171.960 1.00 1.34  ? 79   ARG B NH1 1 
ATOM   1792 N  NH2 . ARG B 1 79  ? 172.519 189.824 169.804 1.00 1.34  ? 79   ARG B NH2 1 
ATOM   1793 N  N   . PHE B 1 80  ? 166.082 194.672 173.520 1.00 1.40  ? 80   PHE B N   1 
ATOM   1794 C  CA  . PHE B 1 80  ? 165.402 195.366 174.601 1.00 1.40  ? 80   PHE B CA  1 
ATOM   1795 C  C   . PHE B 1 80  ? 164.024 194.768 174.837 1.00 1.40  ? 80   PHE B C   1 
ATOM   1796 O  O   . PHE B 1 80  ? 163.689 194.374 175.960 1.00 1.40  ? 80   PHE B O   1 
ATOM   1797 C  CB  . PHE B 1 80  ? 165.299 196.855 174.272 1.00 1.40  ? 80   PHE B CB  1 
ATOM   1798 C  CG  . PHE B 1 80  ? 164.887 197.712 175.433 1.00 1.40  ? 80   PHE B CG  1 
ATOM   1799 C  CD1 . PHE B 1 80  ? 165.559 197.640 176.639 1.00 1.40  ? 80   PHE B CD1 1 
ATOM   1800 C  CD2 . PHE B 1 80  ? 163.835 198.601 175.311 1.00 1.40  ? 80   PHE B CD2 1 
ATOM   1801 C  CE1 . PHE B 1 80  ? 165.183 198.430 177.703 1.00 1.40  ? 80   PHE B CE1 1 
ATOM   1802 C  CE2 . PHE B 1 80  ? 163.455 199.393 176.373 1.00 1.40  ? 80   PHE B CE2 1 
ATOM   1803 C  CZ  . PHE B 1 80  ? 164.130 199.308 177.570 1.00 1.40  ? 80   PHE B CZ  1 
ATOM   1804 N  N   . ILE B 1 81  ? 163.223 194.651 173.777 1.00 1.11  ? 81   ILE B N   1 
ATOM   1805 C  CA  . ILE B 1 81  ? 161.833 194.246 173.964 1.00 1.11  ? 81   ILE B CA  1 
ATOM   1806 C  C   . ILE B 1 81  ? 161.779 192.863 174.594 1.00 1.11  ? 81   ILE B C   1 
ATOM   1807 O  O   . ILE B 1 81  ? 161.111 192.650 175.613 1.00 1.11  ? 81   ILE B O   1 
ATOM   1808 C  CB  . ILE B 1 81  ? 161.074 194.297 172.629 1.00 1.11  ? 81   ILE B CB  1 
ATOM   1809 C  CG1 . ILE B 1 81  ? 161.002 195.736 172.125 1.00 1.11  ? 81   ILE B CG1 1 
ATOM   1810 C  CG2 . ILE B 1 81  ? 159.675 193.747 172.797 1.00 1.11  ? 81   ILE B CG2 1 
ATOM   1811 C  CD1 . ILE B 1 81  ? 160.954 195.848 170.626 1.00 1.11  ? 81   ILE B CD1 1 
ATOM   1812 N  N   . ILE B 1 82  ? 162.519 191.914 174.020 1.00 1.44  ? 82   ILE B N   1 
ATOM   1813 C  CA  . ILE B 1 82  ? 162.658 190.601 174.644 1.00 1.44  ? 82   ILE B CA  1 
ATOM   1814 C  C   . ILE B 1 82  ? 162.947 190.759 176.126 1.00 1.44  ? 82   ILE B C   1 
ATOM   1815 O  O   . ILE B 1 82  ? 162.210 190.253 176.981 1.00 1.44  ? 82   ILE B O   1 
ATOM   1816 C  CB  . ILE B 1 82  ? 163.762 189.785 173.949 1.00 1.44  ? 82   ILE B CB  1 
ATOM   1817 C  CG1 . ILE B 1 82  ? 163.504 189.664 172.444 1.00 1.44  ? 82   ILE B CG1 1 
ATOM   1818 C  CG2 . ILE B 1 82  ? 163.896 188.435 174.602 1.00 1.44  ? 82   ILE B CG2 1 
ATOM   1819 C  CD1 . ILE B 1 82  ? 162.420 188.672 172.087 1.00 1.44  ? 82   ILE B CD1 1 
ATOM   1820 N  N   . PHE B 1 83  ? 164.004 191.505 176.452 1.00 2.00  ? 83   PHE B N   1 
ATOM   1821 C  CA  . PHE B 1 83  ? 164.386 191.667 177.848 1.00 2.00  ? 83   PHE B CA  1 
ATOM   1822 C  C   . PHE B 1 83  ? 163.205 192.154 178.671 1.00 2.00  ? 83   PHE B C   1 
ATOM   1823 O  O   . PHE B 1 83  ? 162.910 191.608 179.740 1.00 2.00  ? 83   PHE B O   1 
ATOM   1824 C  CB  . PHE B 1 83  ? 165.569 192.627 177.957 1.00 2.00  ? 83   PHE B CB  1 
ATOM   1825 C  CG  . PHE B 1 83  ? 165.790 193.161 179.339 1.00 2.00  ? 83   PHE B CG  1 
ATOM   1826 C  CD1 . PHE B 1 83  ? 166.550 192.453 180.251 1.00 2.00  ? 83   PHE B CD1 1 
ATOM   1827 C  CD2 . PHE B 1 83  ? 165.229 194.362 179.731 1.00 2.00  ? 83   PHE B CD2 1 
ATOM   1828 C  CE1 . PHE B 1 83  ? 166.754 192.936 181.523 1.00 2.00  ? 83   PHE B CE1 1 
ATOM   1829 C  CE2 . PHE B 1 83  ? 165.433 194.852 181.000 1.00 2.00  ? 83   PHE B CE2 1 
ATOM   1830 C  CZ  . PHE B 1 83  ? 166.196 194.137 181.899 1.00 2.00  ? 83   PHE B CZ  1 
ATOM   1831 N  N   . LEU B 1 84  ? 162.485 193.156 178.164 1.00 1.99  ? 84   LEU B N   1 
ATOM   1832 C  CA  . LEU B 1 84  ? 161.326 193.651 178.893 1.00 1.99  ? 84   LEU B CA  1 
ATOM   1833 C  C   . LEU B 1 84  ? 160.371 192.511 179.204 1.00 1.99  ? 84   LEU B C   1 
ATOM   1834 O  O   . LEU B 1 84  ? 160.033 192.265 180.369 1.00 1.99  ? 84   LEU B O   1 
ATOM   1835 C  CB  . LEU B 1 84  ? 160.621 194.739 178.083 1.00 1.99  ? 84   LEU B CB  1 
ATOM   1836 C  CG  . LEU B 1 84  ? 161.198 196.151 178.182 1.00 1.99  ? 84   LEU B CG  1 
ATOM   1837 C  CD1 . LEU B 1 84  ? 160.354 197.113 177.366 1.00 1.99  ? 84   LEU B CD1 1 
ATOM   1838 C  CD2 . LEU B 1 84  ? 161.288 196.612 179.626 1.00 1.99  ? 84   LEU B CD2 1 
ATOM   1839 N  N   . PHE B 1 85  ? 159.980 191.754 178.177 1.00 2.23  ? 85   PHE B N   1 
ATOM   1840 C  CA  . PHE B 1 85  ? 159.081 190.631 178.402 1.00 2.23  ? 85   PHE B CA  1 
ATOM   1841 C  C   . PHE B 1 85  ? 159.640 189.722 179.484 1.00 2.23  ? 85   PHE B C   1 
ATOM   1842 O  O   . PHE B 1 85  ? 158.921 189.318 180.404 1.00 2.23  ? 85   PHE B O   1 
ATOM   1843 C  CB  . PHE B 1 85  ? 158.863 189.857 177.102 1.00 2.23  ? 85   PHE B CB  1 
ATOM   1844 C  CG  . PHE B 1 85  ? 158.142 190.641 176.035 1.00 2.23  ? 85   PHE B CG  1 
ATOM   1845 C  CD1 . PHE B 1 85  ? 157.384 191.756 176.354 1.00 2.23  ? 85   PHE B CD1 1 
ATOM   1846 C  CD2 . PHE B 1 85  ? 158.231 190.260 174.707 1.00 2.23  ? 85   PHE B CD2 1 
ATOM   1847 C  CE1 . PHE B 1 85  ? 156.729 192.470 175.371 1.00 2.23  ? 85   PHE B CE1 1 
ATOM   1848 C  CE2 . PHE B 1 85  ? 157.579 190.971 173.722 1.00 2.23  ? 85   PHE B CE2 1 
ATOM   1849 C  CZ  . PHE B 1 85  ? 156.828 192.077 174.055 1.00 2.23  ? 85   PHE B CZ  1 
ATOM   1850 N  N   . ILE B 1 86  ? 160.942 189.435 179.422 1.00 2.36  ? 86   ILE B N   1 
ATOM   1851 C  CA  . ILE B 1 86  ? 161.536 188.550 180.418 1.00 2.36  ? 86   ILE B CA  1 
ATOM   1852 C  C   . ILE B 1 86  ? 161.255 189.085 181.812 1.00 2.36  ? 86   ILE B C   1 
ATOM   1853 O  O   . ILE B 1 86  ? 160.706 188.379 182.667 1.00 2.36  ? 86   ILE B O   1 
ATOM   1854 C  CB  . ILE B 1 86  ? 163.045 188.383 180.167 1.00 2.36  ? 86   ILE B CB  1 
ATOM   1855 C  CG1 . ILE B 1 86  ? 163.281 187.711 178.814 1.00 2.36  ? 86   ILE B CG1 1 
ATOM   1856 C  CG2 . ILE B 1 86  ? 163.683 187.570 181.281 1.00 2.36  ? 86   ILE B CG2 1 
ATOM   1857 C  CD1 . ILE B 1 86  ? 164.717 187.736 178.365 1.00 2.36  ? 86   ILE B CD1 1 
ATOM   1858 N  N   . LEU B 1 87  ? 161.566 190.363 182.044 1.00 2.71  ? 87   LEU B N   1 
ATOM   1859 C  CA  . LEU B 1 87  ? 161.280 190.940 183.351 1.00 2.71  ? 87   LEU B CA  1 
ATOM   1860 C  C   . LEU B 1 87  ? 159.820 190.726 183.703 1.00 2.71  ? 87   LEU B C   1 
ATOM   1861 O  O   . LEU B 1 87  ? 159.494 190.218 184.783 1.00 2.71  ? 87   LEU B O   1 
ATOM   1862 C  CB  . LEU B 1 87  ? 161.621 192.429 183.375 1.00 2.71  ? 87   LEU B CB  1 
ATOM   1863 C  CG  . LEU B 1 87  ? 163.102 192.804 183.349 1.00 2.71  ? 87   LEU B CG  1 
ATOM   1864 C  CD1 . LEU B 1 87  ? 163.235 194.317 183.341 1.00 2.71  ? 87   LEU B CD1 1 
ATOM   1865 C  CD2 . LEU B 1 87  ? 163.852 192.196 184.525 1.00 2.71  ? 87   LEU B CD2 1 
ATOM   1866 N  N   . LEU B 1 88  ? 158.925 191.057 182.772 1.00 3.73  ? 88   LEU B N   1 
ATOM   1867 C  CA  . LEU B 1 88  ? 157.507 190.853 183.023 1.00 3.73  ? 88   LEU B CA  1 
ATOM   1868 C  C   . LEU B 1 88  ? 157.256 189.416 183.452 1.00 3.73  ? 88   LEU B C   1 
ATOM   1869 O  O   . LEU B 1 88  ? 156.683 189.165 184.519 1.00 3.73  ? 88   LEU B O   1 
ATOM   1870 C  CB  . LEU B 1 88  ? 156.702 191.207 181.774 1.00 3.73  ? 88   LEU B CB  1 
ATOM   1871 C  CG  . LEU B 1 88  ? 155.201 190.940 181.836 1.00 3.73  ? 88   LEU B CG  1 
ATOM   1872 C  CD1 . LEU B 1 88  ? 154.450 192.078 181.169 1.00 3.73  ? 88   LEU B CD1 1 
ATOM   1873 C  CD2 . LEU B 1 88  ? 154.858 189.617 181.182 1.00 3.73  ? 88   LEU B CD2 1 
ATOM   1874 N  N   . LEU B 1 89  ? 157.750 188.455 182.667 1.00 3.85  ? 89   LEU B N   1 
ATOM   1875 C  CA  . LEU B 1 89  ? 157.598 187.059 183.054 1.00 3.85  ? 89   LEU B CA  1 
ATOM   1876 C  C   . LEU B 1 89  ? 158.121 186.846 184.465 1.00 3.85  ? 89   LEU B C   1 
ATOM   1877 O  O   . LEU B 1 89  ? 157.401 186.348 185.339 1.00 3.85  ? 89   LEU B O   1 
ATOM   1878 C  CB  . LEU B 1 89  ? 158.327 186.148 182.064 1.00 3.85  ? 89   LEU B CB  1 
ATOM   1879 C  CG  . LEU B 1 89  ? 157.525 185.650 180.858 1.00 3.85  ? 89   LEU B CG  1 
ATOM   1880 C  CD1 . LEU B 1 89  ? 156.332 184.823 181.309 1.00 3.85  ? 89   LEU B CD1 1 
ATOM   1881 C  CD2 . LEU B 1 89  ? 157.072 186.802 179.984 1.00 3.85  ? 89   LEU B CD2 1 
ATOM   1882 N  N   . CYS B 1 90  ? 159.356 187.280 184.723 1.00 5.14  ? 90   CYS B N   1 
ATOM   1883 C  CA  . CYS B 1 90  ? 159.905 187.144 186.064 1.00 5.14  ? 90   CYS B CA  1 
ATOM   1884 C  C   . CYS B 1 90  ? 158.935 187.718 187.083 1.00 5.14  ? 90   CYS B C   1 
ATOM   1885 O  O   . CYS B 1 90  ? 158.543 187.039 188.039 1.00 5.14  ? 90   CYS B O   1 
ATOM   1886 C  CB  . CYS B 1 90  ? 161.261 187.843 186.154 1.00 5.14  ? 90   CYS B CB  1 
ATOM   1887 S  SG  . CYS B 1 90  ? 162.543 187.108 185.121 1.00 5.14  ? 90   CYS B SG  1 
ATOM   1888 N  N   . LEU B 1 91  ? 158.477 188.949 186.850 1.00 6.02  ? 91   LEU B N   1 
ATOM   1889 C  CA  . LEU B 1 91  ? 157.530 189.556 187.774 1.00 6.02  ? 91   LEU B CA  1 
ATOM   1890 C  C   . LEU B 1 91  ? 156.326 188.646 187.963 1.00 6.02  ? 91   LEU B C   1 
ATOM   1891 O  O   . LEU B 1 91  ? 155.989 188.266 189.091 1.00 6.02  ? 91   LEU B O   1 
ATOM   1892 C  CB  . LEU B 1 91  ? 157.101 190.929 187.260 1.00 6.02  ? 91   LEU B CB  1 
ATOM   1893 C  CG  . LEU B 1 91  ? 156.300 191.788 188.240 1.00 6.02  ? 91   LEU B CG  1 
ATOM   1894 C  CD1 . LEU B 1 91  ? 156.562 193.262 187.980 1.00 6.02  ? 91   LEU B CD1 1 
ATOM   1895 C  CD2 . LEU B 1 91  ? 154.813 191.487 188.153 1.00 6.02  ? 91   LEU B CD2 1 
ATOM   1896 N  N   . ILE B 1 92  ? 155.705 188.228 186.858 1.00 5.79  ? 92   ILE B N   1 
ATOM   1897 C  CA  . ILE B 1 92  ? 154.556 187.340 186.969 1.00 5.79  ? 92   ILE B CA  1 
ATOM   1898 C  C   . ILE B 1 92  ? 154.945 186.094 187.747 1.00 5.79  ? 92   ILE B C   1 
ATOM   1899 O  O   . ILE B 1 92  ? 154.239 185.677 188.674 1.00 5.79  ? 92   ILE B O   1 
ATOM   1900 C  CB  . ILE B 1 92  ? 154.002 186.991 185.575 1.00 5.79  ? 92   ILE B CB  1 
ATOM   1901 C  CG1 . ILE B 1 92  ? 153.580 188.257 184.823 1.00 5.79  ? 92   ILE B CG1 1 
ATOM   1902 C  CG2 . ILE B 1 92  ? 152.817 186.050 185.694 1.00 5.79  ? 92   ILE B CG2 1 
ATOM   1903 C  CD1 . ILE B 1 92  ? 152.480 189.055 185.497 1.00 5.79  ? 92   ILE B CD1 1 
ATOM   1904 N  N   . PHE B 1 93  ? 156.097 185.508 187.419 1.00 7.70  ? 93   PHE B N   1 
ATOM   1905 C  CA  . PHE B 1 93  ? 156.549 184.338 188.158 1.00 7.70  ? 93   PHE B CA  1 
ATOM   1906 C  C   . PHE B 1 93  ? 156.643 184.665 189.639 1.00 7.70  ? 93   PHE B C   1 
ATOM   1907 O  O   . PHE B 1 93  ? 156.088 183.953 190.483 1.00 7.70  ? 93   PHE B O   1 
ATOM   1908 C  CB  . PHE B 1 93  ? 157.893 183.859 187.606 1.00 7.70  ? 93   PHE B CB  1 
ATOM   1909 C  CG  . PHE B 1 93  ? 158.512 182.738 188.393 1.00 7.70  ? 93   PHE B CG  1 
ATOM   1910 C  CD1 . PHE B 1 93  ? 159.205 182.987 189.564 1.00 7.70  ? 93   PHE B CD1 1 
ATOM   1911 C  CD2 . PHE B 1 93  ? 158.396 181.429 187.958 1.00 7.70  ? 93   PHE B CD2 1 
ATOM   1912 C  CE1 . PHE B 1 93  ? 159.772 181.956 190.282 1.00 7.70  ? 93   PHE B CE1 1 
ATOM   1913 C  CE2 . PHE B 1 93  ? 158.962 180.393 188.674 1.00 7.70  ? 93   PHE B CE2 1 
ATOM   1914 C  CZ  . PHE B 1 93  ? 159.650 180.658 189.837 1.00 7.70  ? 93   PHE B CZ  1 
ATOM   1915 N  N   . LEU B 1 94  ? 157.306 185.773 189.971 1.00 9.59  ? 94   LEU B N   1 
ATOM   1916 C  CA  . LEU B 1 94  ? 157.353 186.203 191.362 1.00 9.59  ? 94   LEU B CA  1 
ATOM   1917 C  C   . LEU B 1 94  ? 155.941 186.353 191.905 1.00 9.59  ? 94   LEU B C   1 
ATOM   1918 O  O   . LEU B 1 94  ? 155.609 185.829 192.975 1.00 9.59  ? 94   LEU B O   1 
ATOM   1919 C  CB  . LEU B 1 94  ? 158.125 187.519 191.472 1.00 9.59  ? 94   LEU B CB  1 
ATOM   1920 C  CG  . LEU B 1 94  ? 158.438 188.047 192.874 1.00 9.59  ? 94   LEU B CG  1 
ATOM   1921 C  CD1 . LEU B 1 94  ? 159.688 188.910 192.828 1.00 9.59  ? 94   LEU B CD1 1 
ATOM   1922 C  CD2 . LEU B 1 94  ? 157.276 188.838 193.456 1.00 9.59  ? 94   LEU B CD2 1 
ATOM   1923 N  N   . LEU B 1 95  ? 155.078 187.027 191.141 1.00 10.46 ? 95   LEU B N   1 
ATOM   1924 C  CA  . LEU B 1 95  ? 153.714 187.255 191.596 1.00 10.46 ? 95   LEU B CA  1 
ATOM   1925 C  C   . LEU B 1 95  ? 152.985 185.942 191.834 1.00 10.46 ? 95   LEU B C   1 
ATOM   1926 O  O   . LEU B 1 95  ? 152.054 185.888 192.646 1.00 10.46 ? 95   LEU B O   1 
ATOM   1927 C  CB  . LEU B 1 95  ? 152.964 188.110 190.575 1.00 10.46 ? 95   LEU B CB  1 
ATOM   1928 C  CG  . LEU B 1 95  ? 151.736 188.867 191.078 1.00 10.46 ? 95   LEU B CG  1 
ATOM   1929 C  CD1 . LEU B 1 95  ? 152.074 189.698 192.304 1.00 10.46 ? 95   LEU B CD1 1 
ATOM   1930 C  CD2 . LEU B 1 95  ? 151.170 189.744 189.973 1.00 10.46 ? 95   LEU B CD2 1 
ATOM   1931 N  N   . VAL B 1 96  ? 153.383 184.876 191.140 1.00 9.72  ? 96   VAL B N   1 
ATOM   1932 C  CA  . VAL B 1 96  ? 152.783 183.573 191.401 1.00 9.72  ? 96   VAL B CA  1 
ATOM   1933 C  C   . VAL B 1 96  ? 153.199 183.066 192.776 1.00 9.72  ? 96   VAL B C   1 
ATOM   1934 O  O   . VAL B 1 96  ? 152.355 182.675 193.592 1.00 9.72  ? 96   VAL B O   1 
ATOM   1935 C  CB  . VAL B 1 96  ? 153.165 182.575 190.296 1.00 9.72  ? 96   VAL B CB  1 
ATOM   1936 C  CG1 . VAL B 1 96  ? 152.822 181.162 190.724 1.00 9.72  ? 96   VAL B CG1 1 
ATOM   1937 C  CG2 . VAL B 1 96  ? 152.457 182.926 189.001 1.00 9.72  ? 96   VAL B CG2 1 
ATOM   1938 N  N   . LEU B 1 97  ? 154.503 183.102 193.070 1.00 10.86 ? 97   LEU B N   1 
ATOM   1939 C  CA  . LEU B 1 97  ? 154.986 182.479 194.297 1.00 10.86 ? 97   LEU B CA  1 
ATOM   1940 C  C   . LEU B 1 97  ? 154.346 183.113 195.522 1.00 10.86 ? 97   LEU B C   1 
ATOM   1941 O  O   . LEU B 1 97  ? 153.842 182.406 196.403 1.00 10.86 ? 97   LEU B O   1 
ATOM   1942 C  CB  . LEU B 1 97  ? 156.508 182.574 194.384 1.00 10.86 ? 97   LEU B CB  1 
ATOM   1943 C  CG  . LEU B 1 97  ? 157.298 182.235 193.120 1.00 10.86 ? 97   LEU B CG  1 
ATOM   1944 C  CD1 . LEU B 1 97  ? 158.788 182.245 193.422 1.00 10.86 ? 97   LEU B CD1 1 
ATOM   1945 C  CD2 . LEU B 1 97  ? 156.868 180.893 192.557 1.00 10.86 ? 97   LEU B CD2 1 
ATOM   1946 N  N   . LEU B 1 98  ? 154.334 184.445 195.588 1.00 12.62 ? 98   LEU B N   1 
ATOM   1947 C  CA  . LEU B 1 98  ? 153.650 185.109 196.690 1.00 12.62 ? 98   LEU B CA  1 
ATOM   1948 C  C   . LEU B 1 98  ? 152.216 184.614 196.792 1.00 12.62 ? 98   LEU B C   1 
ATOM   1949 O  O   . LEU B 1 98  ? 151.754 184.222 197.871 1.00 12.62 ? 98   LEU B O   1 
ATOM   1950 C  CB  . LEU B 1 98  ? 153.686 186.623 196.493 1.00 12.62 ? 98   LEU B CB  1 
ATOM   1951 C  CG  . LEU B 1 98  ? 155.069 187.268 196.564 1.00 12.62 ? 98   LEU B CG  1 
ATOM   1952 C  CD1 . LEU B 1 98  ? 154.981 188.741 196.213 1.00 12.62 ? 98   LEU B CD1 1 
ATOM   1953 C  CD2 . LEU B 1 98  ? 155.683 187.084 197.945 1.00 12.62 ? 98   LEU B CD2 1 
ATOM   1954 N  N   . ASP B 1 99  ? 151.508 184.584 195.661 1.00 14.64 ? 99   ASP B N   1 
ATOM   1955 C  CA  . ASP B 1 99  ? 150.132 184.105 195.678 1.00 14.64 ? 99   ASP B CA  1 
ATOM   1956 C  C   . ASP B 1 99  ? 150.072 182.659 196.145 1.00 14.64 ? 99   ASP B C   1 
ATOM   1957 O  O   . ASP B 1 99  ? 149.149 182.271 196.870 1.00 14.64 ? 99   ASP B O   1 
ATOM   1958 C  CB  . ASP B 1 99  ? 149.506 184.248 194.294 1.00 14.64 ? 99   ASP B CB  1 
ATOM   1959 C  CG  . ASP B 1 99  ? 148.013 184.006 194.308 1.00 14.64 ? 99   ASP B CG  1 
ATOM   1960 O  OD1 . ASP B 1 99  ? 147.379 184.270 195.350 1.00 14.64 ? 99   ASP B OD1 1 
ATOM   1961 O  OD2 . ASP B 1 99  ? 147.474 183.543 193.283 1.00 14.64 ? 99   ASP B OD2 1 
ATOM   1962 N  N   . TYR B 1 100 ? 151.050 181.845 195.744 1.00 15.54 ? 100  TYR B N   1 
ATOM   1963 C  CA  . TYR B 1 100 ? 151.119 180.488 196.270 1.00 15.54 ? 100  TYR B CA  1 
ATOM   1964 C  C   . TYR B 1 100 ? 151.243 180.503 197.784 1.00 15.54 ? 100  TYR B C   1 
ATOM   1965 O  O   . TYR B 1 100 ? 150.538 179.765 198.480 1.00 15.54 ? 100  TYR B O   1 
ATOM   1966 C  CB  . TYR B 1 100 ? 152.295 179.737 195.647 1.00 15.54 ? 100  TYR B CB  1 
ATOM   1967 C  CG  . TYR B 1 100 ? 152.282 178.252 195.931 1.00 15.54 ? 100  TYR B CG  1 
ATOM   1968 C  CD1 . TYR B 1 100 ? 152.620 177.763 197.186 1.00 15.54 ? 100  TYR B CD1 1 
ATOM   1969 C  CD2 . TYR B 1 100 ? 151.918 177.342 194.951 1.00 15.54 ? 100  TYR B CD2 1 
ATOM   1970 C  CE1 . TYR B 1 100 ? 152.604 176.411 197.453 1.00 15.54 ? 100  TYR B CE1 1 
ATOM   1971 C  CE2 . TYR B 1 100 ? 151.898 175.985 195.209 1.00 15.54 ? 100  TYR B CE2 1 
ATOM   1972 C  CZ  . TYR B 1 100 ? 152.242 175.525 196.462 1.00 15.54 ? 100  TYR B CZ  1 
ATOM   1973 O  OH  . TYR B 1 100 ? 152.224 174.174 196.723 1.00 15.54 ? 100  TYR B OH  1 
ATOM   1974 N  N   . GLN B 1 101 ? 152.118 181.349 198.314 1.00 14.63 ? 101  GLN B N   1 
ATOM   1975 C  CA  . GLN B 1 101 ? 152.383 181.364 199.741 1.00 14.63 ? 101  GLN B CA  1 
ATOM   1976 C  C   . GLN B 1 101 ? 151.318 182.110 200.529 1.00 14.63 ? 101  GLN B C   1 
ATOM   1977 O  O   . GLN B 1 101 ? 151.353 182.085 201.763 1.00 14.63 ? 101  GLN B O   1 
ATOM   1978 C  CB  . GLN B 1 101 ? 153.758 181.984 200.004 1.00 14.63 ? 101  GLN B CB  1 
ATOM   1979 C  CG  . GLN B 1 101 ? 154.894 181.205 199.363 1.00 14.63 ? 101  GLN B CG  1 
ATOM   1980 C  CD  . GLN B 1 101 ? 156.239 181.506 199.983 1.00 14.63 ? 101  GLN B CD  1 
ATOM   1981 O  OE1 . GLN B 1 101 ? 156.370 182.416 200.802 1.00 14.63 ? 101  GLN B OE1 1 
ATOM   1982 N  NE2 . GLN B 1 101 ? 157.251 180.735 199.601 1.00 14.63 ? 101  GLN B NE2 1 
ATOM   1983 N  N   . GLY B 1 102 ? 150.374 182.758 199.852 1.00 13.36 ? 102  GLY B N   1 
ATOM   1984 C  CA  . GLY B 1 102 ? 149.342 183.501 200.545 1.00 13.36 ? 102  GLY B CA  1 
ATOM   1985 C  C   . GLY B 1 102 ? 149.804 184.816 201.122 1.00 13.36 ? 102  GLY B C   1 
ATOM   1986 O  O   . GLY B 1 102 ? 149.219 185.295 202.100 1.00 13.36 ? 102  GLY B O   1 
ATOM   1987 N  N   . MET B 1 103 ? 150.842 185.419 200.549 1.00 14.53 ? 103  MET B N   1 
ATOM   1988 C  CA  . MET B 1 103 ? 151.343 186.704 201.012 1.00 14.53 ? 103  MET B CA  1 
ATOM   1989 C  C   . MET B 1 103 ? 150.611 187.878 200.376 1.00 14.53 ? 103  MET B C   1 
ATOM   1990 O  O   . MET B 1 103 ? 150.966 189.031 200.640 1.00 14.53 ? 103  MET B O   1 
ATOM   1991 C  CB  . MET B 1 103 ? 152.844 186.818 200.738 1.00 14.53 ? 103  MET B CB  1 
ATOM   1992 C  CG  . MET B 1 103 ? 153.705 186.541 201.962 1.00 14.53 ? 103  MET B CG  1 
ATOM   1993 S  SD  . MET B 1 103 ? 153.572 187.783 203.271 1.00 14.53 ? 103  MET B SD  1 
ATOM   1994 C  CE  . MET B 1 103 ? 153.726 189.320 202.362 1.00 14.53 ? 103  MET B CE  1 
ATOM   1995 N  N   . LEU B 1 104 ? 149.599 187.613 199.550 1.00 13.19 ? 104  LEU B N   1 
ATOM   1996 C  CA  . LEU B 1 104 ? 148.762 188.662 198.988 1.00 13.19 ? 104  LEU B CA  1 
ATOM   1997 C  C   . LEU B 1 104 ? 147.440 188.639 199.734 1.00 13.19 ? 104  LEU B C   1 
ATOM   1998 O  O   . LEU B 1 104 ? 146.484 188.000 199.270 1.00 13.19 ? 104  LEU B O   1 
ATOM   1999 C  CB  . LEU B 1 104 ? 148.541 188.435 197.492 1.00 13.19 ? 104  LEU B CB  1 
ATOM   2000 C  CG  . LEU B 1 104 ? 149.519 189.137 196.553 1.00 13.19 ? 104  LEU B CG  1 
ATOM   2001 C  CD1 . LEU B 1 104 ? 150.911 188.571 196.714 1.00 13.19 ? 104  LEU B CD1 1 
ATOM   2002 C  CD2 . LEU B 1 104 ? 149.056 188.992 195.120 1.00 13.19 ? 104  LEU B CD2 1 
ATOM   2003 N  N   . PRO B 1 105 ? 147.319 189.314 200.874 1.00 16.97 ? 105  PRO B N   1 
ATOM   2004 C  CA  . PRO B 1 105 ? 146.085 189.184 201.673 1.00 16.97 ? 105  PRO B CA  1 
ATOM   2005 C  C   . PRO B 1 105 ? 144.901 189.868 200.998 1.00 16.97 ? 105  PRO B C   1 
ATOM   2006 O  O   . PRO B 1 105 ? 144.393 190.904 201.419 1.00 16.97 ? 105  PRO B O   1 
ATOM   2007 C  CB  . PRO B 1 105 ? 146.470 189.852 202.994 1.00 16.97 ? 105  PRO B CB  1 
ATOM   2008 C  CG  . PRO B 1 105 ? 147.477 190.873 202.607 1.00 16.97 ? 105  PRO B CG  1 
ATOM   2009 C  CD  . PRO B 1 105 ? 148.260 190.276 201.470 1.00 16.97 ? 105  PRO B CD  1 
ATOM   2010 N  N   . VAL B 1 106 ? 144.446 189.259 199.909 1.00 15.57 ? 106  VAL B N   1 
ATOM   2011 C  CA  . VAL B 1 106 ? 143.334 189.777 199.125 1.00 15.57 ? 106  VAL B CA  1 
ATOM   2012 C  C   . VAL B 1 106 ? 142.043 189.328 199.790 1.00 15.57 ? 106  VAL B C   1 
ATOM   2013 O  O   . VAL B 1 106 ? 141.837 188.130 200.020 1.00 15.57 ? 106  VAL B O   1 
ATOM   2014 C  CB  . VAL B 1 106 ? 143.406 189.300 197.668 1.00 15.57 ? 106  VAL B CB  1 
ATOM   2015 C  CG1 . VAL B 1 106 ? 142.180 189.748 196.903 1.00 15.57 ? 106  VAL B CG1 1 
ATOM   2016 C  CG2 . VAL B 1 106 ? 144.666 189.820 197.006 1.00 15.57 ? 106  VAL B CG2 1 
ATOM   2017 N  N   . CYS B 1 107 ? 141.178 190.281 200.106 1.00 18.73 ? 107  CYS B N   1 
ATOM   2018 C  CA  . CYS B 1 107 ? 139.927 189.951 200.774 1.00 18.73 ? 107  CYS B CA  1 
ATOM   2019 C  C   . CYS B 1 107 ? 138.960 189.323 199.773 1.00 18.73 ? 107  CYS B C   1 
ATOM   2020 O  O   . CYS B 1 107 ? 138.637 189.949 198.759 1.00 18.73 ? 107  CYS B O   1 
ATOM   2021 C  CB  . CYS B 1 107 ? 139.312 191.202 201.395 1.00 18.73 ? 107  CYS B CB  1 
ATOM   2022 S  SG  . CYS B 1 107 ? 137.840 190.886 202.397 1.00 18.73 ? 107  CYS B SG  1 
ATOM   2023 N  N   . PRO B 1 108 ? 138.482 188.104 200.011 1.00 21.95 ? 108  PRO B N   1 
ATOM   2024 C  CA  . PRO B 1 108 ? 137.529 187.500 199.076 1.00 21.95 ? 108  PRO B CA  1 
ATOM   2025 C  C   . PRO B 1 108 ? 136.218 188.269 199.035 1.00 21.95 ? 108  PRO B C   1 
ATOM   2026 O  O   . PRO B 1 108 ? 135.827 188.948 199.987 1.00 21.95 ? 108  PRO B O   1 
ATOM   2027 C  CB  . PRO B 1 108 ? 137.323 186.086 199.634 1.00 21.95 ? 108  PRO B CB  1 
ATOM   2028 C  CG  . PRO B 1 108 ? 138.517 185.828 200.471 1.00 21.95 ? 108  PRO B CG  1 
ATOM   2029 C  CD  . PRO B 1 108 ? 138.890 187.151 201.057 1.00 21.95 ? 108  PRO B CD  1 
ATOM   2030 N  N   . LEU B 1 109 ? 135.539 188.153 197.896 1.00 25.56 ? 109  LEU B N   1 
ATOM   2031 C  CA  . LEU B 1 109 ? 134.247 188.801 197.730 1.00 25.56 ? 109  LEU B CA  1 
ATOM   2032 C  C   . LEU B 1 109 ? 133.248 188.253 198.740 1.00 25.56 ? 109  LEU B C   1 
ATOM   2033 O  O   . LEU B 1 109 ? 133.125 187.039 198.924 1.00 25.56 ? 109  LEU B O   1 
ATOM   2034 C  CB  . LEU B 1 109 ? 133.732 188.588 196.305 1.00 25.56 ? 109  LEU B CB  1 
ATOM   2035 C  CG  . LEU B 1 109 ? 132.372 189.207 195.967 1.00 25.56 ? 109  LEU B CG  1 
ATOM   2036 C  CD1 . LEU B 1 109 ? 132.432 190.722 196.048 1.00 25.56 ? 109  LEU B CD1 1 
ATOM   2037 C  CD2 . LEU B 1 109 ? 131.916 188.764 194.588 1.00 25.56 ? 109  LEU B CD2 1 
ATOM   2038 N  N   . ILE B 1 110 ? 132.529 189.159 199.395 1.00 30.42 ? 110  ILE B N   1 
ATOM   2039 C  CA  . ILE B 1 110 ? 131.546 188.781 200.403 1.00 30.42 ? 110  ILE B CA  1 
ATOM   2040 C  C   . ILE B 1 110 ? 130.306 188.198 199.733 1.00 30.42 ? 110  ILE B C   1 
ATOM   2041 O  O   . ILE B 1 110 ? 130.401 187.509 198.717 1.00 30.42 ? 110  ILE B O   1 
ATOM   2042 C  CB  . ILE B 1 110 ? 131.178 189.985 201.295 1.00 30.42 ? 110  ILE B CB  1 
ATOM   2043 C  CG1 . ILE B 1 110 ? 130.386 189.528 202.522 1.00 30.42 ? 110  ILE B CG1 1 
ATOM   2044 C  CG2 . ILE B 1 110 ? 130.380 191.013 200.506 1.00 30.42 ? 110  ILE B CG2 1 
ATOM   2045 C  CD1 . ILE B 1 110 ? 131.212 188.782 203.543 1.00 30.42 ? 110  ILE B CD1 1 
ATOM   2046 N  N   . ILE B 1 150 ? 136.245 188.984 206.402 1.00 29.39 ? 150  ILE B N   1 
ATOM   2047 C  CA  . ILE B 1 150 ? 136.070 187.547 206.247 1.00 29.39 ? 150  ILE B CA  1 
ATOM   2048 C  C   . ILE B 1 150 ? 137.434 186.859 206.322 1.00 29.39 ? 150  ILE B C   1 
ATOM   2049 O  O   . ILE B 1 150 ? 138.416 187.389 205.802 1.00 29.39 ? 150  ILE B O   1 
ATOM   2050 C  CB  . ILE B 1 150 ? 135.343 187.222 204.926 1.00 29.39 ? 150  ILE B CB  1 
ATOM   2051 C  CG1 . ILE B 1 150 ? 134.536 185.928 205.063 1.00 29.39 ? 150  ILE B CG1 1 
ATOM   2052 C  CG2 . ILE B 1 150 ? 136.333 187.117 203.775 1.00 29.39 ? 150  ILE B CG2 1 
ATOM   2053 C  CD1 . ILE B 1 150 ? 133.624 185.644 203.885 1.00 29.39 ? 150  ILE B CD1 1 
ATOM   2054 N  N   . PRO B 1 151 ? 137.501 185.693 206.971 1.00 27.27 ? 151  PRO B N   1 
ATOM   2055 C  CA  . PRO B 1 151 ? 138.786 184.995 207.098 1.00 27.27 ? 151  PRO B CA  1 
ATOM   2056 C  C   . PRO B 1 151 ? 139.521 184.894 205.769 1.00 27.27 ? 151  PRO B C   1 
ATOM   2057 O  O   . PRO B 1 151 ? 138.914 184.781 204.702 1.00 27.27 ? 151  PRO B O   1 
ATOM   2058 C  CB  . PRO B 1 151 ? 138.388 183.616 207.630 1.00 27.27 ? 151  PRO B CB  1 
ATOM   2059 C  CG  . PRO B 1 151 ? 137.124 183.848 208.378 1.00 27.27 ? 151  PRO B CG  1 
ATOM   2060 C  CD  . PRO B 1 151 ? 136.454 185.067 207.799 1.00 27.27 ? 151  PRO B CD  1 
ATOM   2061 N  N   . ILE B 1 152 ? 140.844 184.932 205.852 1.00 22.65 ? 152  ILE B N   1 
ATOM   2062 C  CA  . ILE B 1 152 ? 141.683 185.095 204.659 1.00 22.65 ? 152  ILE B CA  1 
ATOM   2063 C  C   . ILE B 1 152 ? 141.845 183.748 203.964 1.00 22.65 ? 152  ILE B C   1 
ATOM   2064 O  O   . ILE B 1 152 ? 141.833 182.702 204.637 1.00 22.65 ? 152  ILE B O   1 
ATOM   2065 C  CB  . ILE B 1 152 ? 143.044 185.668 205.045 1.00 22.65 ? 152  ILE B CB  1 
ATOM   2066 C  CG1 . ILE B 1 152 ? 142.879 187.044 205.688 1.00 22.65 ? 152  ILE B CG1 1 
ATOM   2067 C  CG2 . ILE B 1 152 ? 143.943 185.757 203.821 1.00 22.65 ? 152  ILE B CG2 1 
ATOM   2068 C  CD1 . ILE B 1 152 ? 142.704 186.997 207.194 1.00 22.65 ? 152  ILE B CD1 1 
ATOM   2069 N  N   . PRO B 1 153 ? 142.001 183.712 202.640 1.00 18.82 ? 153  PRO B N   1 
ATOM   2070 C  CA  . PRO B 1 153 ? 142.479 182.486 201.987 1.00 18.82 ? 153  PRO B CA  1 
ATOM   2071 C  C   . PRO B 1 153 ? 143.948 182.265 202.311 1.00 18.82 ? 153  PRO B C   1 
ATOM   2072 O  O   . PRO B 1 153 ? 144.806 183.058 201.920 1.00 18.82 ? 153  PRO B O   1 
ATOM   2073 C  CB  . PRO B 1 153 ? 142.263 182.767 200.496 1.00 18.82 ? 153  PRO B CB  1 
ATOM   2074 C  CG  . PRO B 1 153 ? 141.228 183.834 200.457 1.00 18.82 ? 153  PRO B CG  1 
ATOM   2075 C  CD  . PRO B 1 153 ? 141.489 184.683 201.660 1.00 18.82 ? 153  PRO B CD  1 
ATOM   2076 N  N   . SER B 1 154 ? 144.236 181.181 203.033 1.00 15.64 ? 154  SER B N   1 
ATOM   2077 C  CA  . SER B 1 154 ? 145.602 180.935 203.480 1.00 15.64 ? 154  SER B CA  1 
ATOM   2078 C  C   . SER B 1 154 ? 146.569 180.911 202.303 1.00 15.64 ? 154  SER B C   1 
ATOM   2079 O  O   . SER B 1 154 ? 147.713 181.362 202.417 1.00 15.64 ? 154  SER B O   1 
ATOM   2080 C  CB  . SER B 1 154 ? 145.672 179.622 204.260 1.00 15.64 ? 154  SER B CB  1 
ATOM   2081 O  OG  . SER B 1 154 ? 145.889 178.524 203.391 1.00 15.64 ? 154  SER B OG  1 
ATOM   2082 N  N   . SER B 1 155 ? 146.129 180.383 201.164 1.00 15.85 ? 155  SER B N   1 
ATOM   2083 C  CA  . SER B 1 155 ? 146.963 180.293 199.976 1.00 15.85 ? 155  SER B CA  1 
ATOM   2084 C  C   . SER B 1 155 ? 146.159 180.652 198.734 1.00 15.85 ? 155  SER B C   1 
ATOM   2085 O  O   . SER B 1 155 ? 144.939 180.478 198.682 1.00 15.85 ? 155  SER B O   1 
ATOM   2086 C  CB  . SER B 1 155 ? 147.552 178.887 199.819 1.00 15.85 ? 155  SER B CB  1 
ATOM   2087 O  OG  . SER B 1 155 ? 146.662 178.041 199.116 1.00 15.85 ? 155  SER B OG  1 
ATOM   2088 N  N   . TRP B 1 156 ? 146.871 181.158 197.727 1.00 15.90 ? 156  TRP B N   1 
ATOM   2089 C  CA  . TRP B 1 156 ? 146.286 181.466 196.423 1.00 15.90 ? 156  TRP B CA  1 
ATOM   2090 C  C   . TRP B 1 156 ? 145.097 182.414 196.552 1.00 15.90 ? 156  TRP B C   1 
ATOM   2091 O  O   . TRP B 1 156 ? 144.119 182.313 195.812 1.00 15.90 ? 156  TRP B O   1 
ATOM   2092 C  CB  . TRP B 1 156 ? 145.870 180.186 195.698 1.00 15.90 ? 156  TRP B CB  1 
ATOM   2093 C  CG  . TRP B 1 156 ? 147.018 179.332 195.275 1.00 15.90 ? 156  TRP B CG  1 
ATOM   2094 C  CD1 . TRP B 1 156 ? 147.764 178.514 196.067 1.00 15.90 ? 156  TRP B CD1 1 
ATOM   2095 C  CD2 . TRP B 1 156 ? 147.550 179.206 193.952 1.00 15.90 ? 156  TRP B CD2 1 
ATOM   2096 N  NE1 . TRP B 1 156 ? 148.729 177.885 195.321 1.00 15.90 ? 156  TRP B NE1 1 
ATOM   2097 C  CE2 . TRP B 1 156 ? 148.619 178.294 194.018 1.00 15.90 ? 156  TRP B CE2 1 
ATOM   2098 C  CE3 . TRP B 1 156 ? 147.226 179.777 192.718 1.00 15.90 ? 156  TRP B CE3 1 
ATOM   2099 C  CZ2 . TRP B 1 156 ? 149.366 177.939 192.899 1.00 15.90 ? 156  TRP B CZ2 1 
ATOM   2100 C  CZ3 . TRP B 1 156 ? 147.968 179.423 191.609 1.00 15.90 ? 156  TRP B CZ3 1 
ATOM   2101 C  CH2 . TRP B 1 156 ? 149.026 178.513 191.706 1.00 15.90 ? 156  TRP B CH2 1 
ATOM   2102 N  N   . ALA B 1 157 ? 145.183 183.356 197.489 1.00 14.94 ? 157  ALA B N   1 
ATOM   2103 C  CA  . ALA B 1 157 ? 144.073 184.278 197.698 1.00 14.94 ? 157  ALA B CA  1 
ATOM   2104 C  C   . ALA B 1 157 ? 143.788 185.096 196.446 1.00 14.94 ? 157  ALA B C   1 
ATOM   2105 O  O   . ALA B 1 157 ? 142.623 185.278 196.071 1.00 14.94 ? 157  ALA B O   1 
ATOM   2106 C  CB  . ALA B 1 157 ? 144.375 185.201 198.877 1.00 14.94 ? 157  ALA B CB  1 
ATOM   2107 N  N   . PHE B 1 158 ? 144.835 185.587 195.783 1.00 13.35 ? 158  PHE B N   1 
ATOM   2108 C  CA  . PHE B 1 158 ? 144.634 186.390 194.583 1.00 13.35 ? 158  PHE B CA  1 
ATOM   2109 C  C   . PHE B 1 158 ? 143.960 185.580 193.485 1.00 13.35 ? 158  PHE B C   1 
ATOM   2110 O  O   . PHE B 1 158 ? 143.043 186.070 192.819 1.00 13.35 ? 158  PHE B O   1 
ATOM   2111 C  CB  . PHE B 1 158 ? 145.969 186.941 194.090 1.00 13.35 ? 158  PHE B CB  1 
ATOM   2112 C  CG  . PHE B 1 158 ? 145.838 187.929 192.971 1.00 13.35 ? 158  PHE B CG  1 
ATOM   2113 C  CD1 . PHE B 1 158 ? 145.102 189.089 193.137 1.00 13.35 ? 158  PHE B CD1 1 
ATOM   2114 C  CD2 . PHE B 1 158 ? 146.448 187.698 191.754 1.00 13.35 ? 158  PHE B CD2 1 
ATOM   2115 C  CE1 . PHE B 1 158 ? 144.980 190.001 192.109 1.00 13.35 ? 158  PHE B CE1 1 
ATOM   2116 C  CE2 . PHE B 1 158 ? 146.330 188.606 190.723 1.00 13.35 ? 158  PHE B CE2 1 
ATOM   2117 C  CZ  . PHE B 1 158 ? 145.595 189.759 190.901 1.00 13.35 ? 158  PHE B CZ  1 
ATOM   2118 N  N   . GLY B 1 159 ? 144.405 184.342 193.274 1.00 14.90 ? 159  GLY B N   1 
ATOM   2119 C  CA  . GLY B 1 159 ? 143.804 183.527 192.233 1.00 14.90 ? 159  GLY B CA  1 
ATOM   2120 C  C   . GLY B 1 159 ? 142.338 183.240 192.494 1.00 14.90 ? 159  GLY B C   1 
ATOM   2121 O  O   . GLY B 1 159 ? 141.500 183.362 191.597 1.00 14.90 ? 159  GLY B O   1 
ATOM   2122 N  N   . LYS B 1 160 ? 142.009 182.851 193.727 1.00 15.68 ? 160  LYS B N   1 
ATOM   2123 C  CA  . LYS B 1 160 ? 140.617 182.574 194.058 1.00 15.68 ? 160  LYS B CA  1 
ATOM   2124 C  C   . LYS B 1 160 ? 139.761 183.822 193.905 1.00 15.68 ? 160  LYS B C   1 
ATOM   2125 O  O   . LYS B 1 160 ? 138.662 183.757 193.347 1.00 15.68 ? 160  LYS B O   1 
ATOM   2126 C  CB  . LYS B 1 160 ? 140.510 182.019 195.478 1.00 15.68 ? 160  LYS B CB  1 
ATOM   2127 C  CG  . LYS B 1 160 ? 141.352 180.773 195.738 1.00 15.68 ? 160  LYS B CG  1 
ATOM   2128 C  CD  . LYS B 1 160 ? 140.838 179.564 194.972 1.00 15.68 ? 160  LYS B CD  1 
ATOM   2129 C  CE  . LYS B 1 160 ? 141.962 178.599 194.643 1.00 15.68 ? 160  LYS B CE  1 
ATOM   2130 N  NZ  . LYS B 1 160 ? 142.793 179.077 193.504 1.00 15.68 ? 160  LYS B NZ  1 
ATOM   2131 N  N   . PHE B 1 161 ? 140.248 184.970 194.382 1.00 14.20 ? 161  PHE B N   1 
ATOM   2132 C  CA  . PHE B 1 161 ? 139.478 186.199 194.227 1.00 14.20 ? 161  PHE B CA  1 
ATOM   2133 C  C   . PHE B 1 161 ? 139.266 186.538 192.759 1.00 14.20 ? 161  PHE B C   1 
ATOM   2134 O  O   . PHE B 1 161 ? 138.152 186.890 192.351 1.00 14.20 ? 161  PHE B O   1 
ATOM   2135 C  CB  . PHE B 1 161 ? 140.178 187.357 194.932 1.00 14.20 ? 161  PHE B CB  1 
ATOM   2136 C  CG  . PHE B 1 161 ? 139.710 188.709 194.473 1.00 14.20 ? 161  PHE B CG  1 
ATOM   2137 C  CD1 . PHE B 1 161 ? 140.321 189.341 193.404 1.00 14.20 ? 161  PHE B CD1 1 
ATOM   2138 C  CD2 . PHE B 1 161 ? 138.655 189.341 195.103 1.00 14.20 ? 161  PHE B CD2 1 
ATOM   2139 C  CE1 . PHE B 1 161 ? 139.892 190.570 192.980 1.00 14.20 ? 161  PHE B CE1 1 
ATOM   2140 C  CE2 . PHE B 1 161 ? 138.225 190.574 194.681 1.00 14.20 ? 161  PHE B CE2 1 
ATOM   2141 C  CZ  . PHE B 1 161 ? 138.844 191.188 193.618 1.00 14.20 ? 161  PHE B CZ  1 
ATOM   2142 N  N   . LEU B 1 162 ? 140.326 186.458 191.954 1.00 13.07 ? 162  LEU B N   1 
ATOM   2143 C  CA  . LEU B 1 162 ? 140.211 186.806 190.545 1.00 13.07 ? 162  LEU B CA  1 
ATOM   2144 C  C   . LEU B 1 162 ? 139.224 185.889 189.836 1.00 13.07 ? 162  LEU B C   1 
ATOM   2145 O  O   . LEU B 1 162 ? 138.375 186.353 189.063 1.00 13.07 ? 162  LEU B O   1 
ATOM   2146 C  CB  . LEU B 1 162 ? 141.586 186.733 189.884 1.00 13.07 ? 162  LEU B CB  1 
ATOM   2147 C  CG  . LEU B 1 162 ? 141.708 187.340 188.489 1.00 13.07 ? 162  LEU B CG  1 
ATOM   2148 C  CD1 . LEU B 1 162 ? 141.692 188.856 188.564 1.00 13.07 ? 162  LEU B CD1 1 
ATOM   2149 C  CD2 . LEU B 1 162 ? 142.974 186.845 187.811 1.00 13.07 ? 162  LEU B CD2 1 
ATOM   2150 N  N   . TRP B 1 163 ? 139.312 184.581 190.091 1.00 15.93 ? 163  TRP B N   1 
ATOM   2151 C  CA  . TRP B 1 163 ? 138.392 183.656 189.442 1.00 15.93 ? 163  TRP B CA  1 
ATOM   2152 C  C   . TRP B 1 163 ? 136.964 183.880 189.914 1.00 15.93 ? 163  TRP B C   1 
ATOM   2153 O  O   . TRP B 1 163 ? 136.024 183.790 189.118 1.00 15.93 ? 163  TRP B O   1 
ATOM   2154 C  CB  . TRP B 1 163 ? 138.806 182.210 189.698 1.00 15.93 ? 163  TRP B CB  1 
ATOM   2155 C  CG  . TRP B 1 163 ? 137.929 181.240 188.974 1.00 15.93 ? 163  TRP B CG  1 
ATOM   2156 C  CD1 . TRP B 1 163 ? 137.894 181.016 187.629 1.00 15.93 ? 163  TRP B CD1 1 
ATOM   2157 C  CD2 . TRP B 1 163 ? 136.942 180.378 189.550 1.00 15.93 ? 163  TRP B CD2 1 
ATOM   2158 N  NE1 . TRP B 1 163 ? 136.953 180.061 187.332 1.00 15.93 ? 163  TRP B NE1 1 
ATOM   2159 C  CE2 . TRP B 1 163 ? 136.355 179.653 188.495 1.00 15.93 ? 163  TRP B CE2 1 
ATOM   2160 C  CE3 . TRP B 1 163 ? 136.502 180.144 190.856 1.00 15.93 ? 163  TRP B CE3 1 
ATOM   2161 C  CZ2 . TRP B 1 163 ? 135.352 178.711 188.705 1.00 15.93 ? 163  TRP B CZ2 1 
ATOM   2162 C  CZ3 . TRP B 1 163 ? 135.506 179.208 191.062 1.00 15.93 ? 163  TRP B CZ3 1 
ATOM   2163 C  CH2 . TRP B 1 163 ? 134.942 178.504 189.993 1.00 15.93 ? 163  TRP B CH2 1 
ATOM   2164 N  N   . GLU B 1 164 ? 136.773 184.153 191.206 1.00 15.61 ? 164  GLU B N   1 
ATOM   2165 C  CA  . GLU B 1 164 ? 135.429 184.417 191.701 1.00 15.61 ? 164  GLU B CA  1 
ATOM   2166 C  C   . GLU B 1 164 ? 134.836 185.637 191.016 1.00 15.61 ? 164  GLU B C   1 
ATOM   2167 O  O   . GLU B 1 164 ? 133.681 185.613 190.579 1.00 15.61 ? 164  GLU B O   1 
ATOM   2168 C  CB  . GLU B 1 164 ? 135.463 184.606 193.219 1.00 15.61 ? 164  GLU B CB  1 
ATOM   2169 C  CG  . GLU B 1 164 ? 134.155 185.079 193.845 1.00 15.61 ? 164  GLU B CG  1 
ATOM   2170 C  CD  . GLU B 1 164 ? 133.068 184.022 193.820 1.00 15.61 ? 164  GLU B CD  1 
ATOM   2171 O  OE1 . GLU B 1 164 ? 133.062 183.187 192.893 1.00 15.61 ? 164  GLU B OE1 1 
ATOM   2172 O  OE2 . GLU B 1 164 ? 132.216 184.027 194.732 1.00 15.61 ? 164  GLU B OE2 1 
ATOM   2173 N  N   . TRP B 1 165 ? 135.620 186.709 190.898 1.00 14.34 ? 165  TRP B N   1 
ATOM   2174 C  CA  . TRP B 1 165 ? 135.135 187.907 190.223 1.00 14.34 ? 165  TRP B CA  1 
ATOM   2175 C  C   . TRP B 1 165 ? 134.793 187.616 188.767 1.00 14.34 ? 165  TRP B C   1 
ATOM   2176 O  O   . TRP B 1 165 ? 133.729 188.018 188.274 1.00 14.34 ? 165  TRP B O   1 
ATOM   2177 C  CB  . TRP B 1 165 ? 136.189 189.009 190.329 1.00 14.34 ? 165  TRP B CB  1 
ATOM   2178 C  CG  . TRP B 1 165 ? 135.984 190.157 189.402 1.00 14.34 ? 165  TRP B CG  1 
ATOM   2179 C  CD1 . TRP B 1 165 ? 135.289 191.300 189.655 1.00 14.34 ? 165  TRP B CD1 1 
ATOM   2180 C  CD2 . TRP B 1 165 ? 136.488 190.279 188.069 1.00 14.34 ? 165  TRP B CD2 1 
ATOM   2181 N  NE1 . TRP B 1 165 ? 135.328 192.128 188.562 1.00 14.34 ? 165  TRP B NE1 1 
ATOM   2182 C  CE2 . TRP B 1 165 ? 136.058 191.523 187.574 1.00 14.34 ? 165  TRP B CE2 1 
ATOM   2183 C  CE3 . TRP B 1 165 ? 137.260 189.456 187.245 1.00 14.34 ? 165  TRP B CE3 1 
ATOM   2184 C  CZ2 . TRP B 1 165 ? 136.372 191.963 186.292 1.00 14.34 ? 165  TRP B CZ2 1 
ATOM   2185 C  CZ3 . TRP B 1 165 ? 137.571 189.894 185.974 1.00 14.34 ? 165  TRP B CZ3 1 
ATOM   2186 C  CH2 . TRP B 1 165 ? 137.128 191.136 185.510 1.00 14.34 ? 165  TRP B CH2 1 
ATOM   2187 N  N   . ALA B 1 166 ? 135.676 186.902 188.064 1.00 17.95 ? 166  ALA B N   1 
ATOM   2188 C  CA  . ALA B 1 166 ? 135.435 186.613 186.655 1.00 17.95 ? 166  ALA B CA  1 
ATOM   2189 C  C   . ALA B 1 166 ? 134.180 185.771 186.469 1.00 17.95 ? 166  ALA B C   1 
ATOM   2190 O  O   . ALA B 1 166 ? 133.345 186.068 185.606 1.00 17.95 ? 166  ALA B O   1 
ATOM   2191 C  CB  . ALA B 1 166 ? 136.646 185.902 186.051 1.00 17.95 ? 166  ALA B CB  1 
ATOM   2192 N  N   . SER B 1 167 ? 134.028 184.713 187.267 1.00 20.17 ? 167  SER B N   1 
ATOM   2193 C  CA  . SER B 1 167 ? 132.853 183.859 187.144 1.00 20.17 ? 167  SER B CA  1 
ATOM   2194 C  C   . SER B 1 167 ? 131.584 184.618 187.502 1.00 20.17 ? 167  SER B C   1 
ATOM   2195 O  O   . SER B 1 167 ? 130.549 184.450 186.848 1.00 20.17 ? 167  SER B O   1 
ATOM   2196 C  CB  . SER B 1 167 ? 133.008 182.623 188.029 1.00 20.17 ? 167  SER B CB  1 
ATOM   2197 O  OG  . SER B 1 167 ? 133.773 181.624 187.378 1.00 20.17 ? 167  SER B OG  1 
ATOM   2198 N  N   . ALA B 1 168 ? 131.642 185.461 188.536 1.00 19.85 ? 168  ALA B N   1 
ATOM   2199 C  CA  . ALA B 1 168 ? 130.461 186.213 188.937 1.00 19.85 ? 168  ALA B CA  1 
ATOM   2200 C  C   . ALA B 1 168 ? 130.023 187.175 187.843 1.00 19.85 ? 168  ALA B C   1 
ATOM   2201 O  O   . ALA B 1 168 ? 128.825 187.307 187.569 1.00 19.85 ? 168  ALA B O   1 
ATOM   2202 C  CB  . ALA B 1 168 ? 130.739 186.970 190.234 1.00 19.85 ? 168  ALA B CB  1 
ATOM   2203 N  N   . ARG B 1 169 ? 130.975 187.855 187.202 1.00 20.12 ? 169  ARG B N   1 
ATOM   2204 C  CA  . ARG B 1 169 ? 130.599 188.861 186.212 1.00 20.12 ? 169  ARG B CA  1 
ATOM   2205 C  C   . ARG B 1 169 ? 130.305 188.243 184.848 1.00 20.12 ? 169  ARG B C   1 
ATOM   2206 O  O   . ARG B 1 169 ? 129.181 188.340 184.343 1.00 20.12 ? 169  ARG B O   1 
ATOM   2207 C  CB  . ARG B 1 169 ? 131.697 189.916 186.090 1.00 20.12 ? 169  ARG B CB  1 
ATOM   2208 C  CG  . ARG B 1 169 ? 131.876 190.754 187.344 1.00 20.12 ? 169  ARG B CG  1 
ATOM   2209 C  CD  . ARG B 1 169 ? 132.570 192.090 187.079 1.00 20.12 ? 169  ARG B CD  1 
ATOM   2210 N  NE  . ARG B 1 169 ? 131.983 192.863 185.990 1.00 20.12 ? 169  ARG B NE  1 
ATOM   2211 C  CZ  . ARG B 1 169 ? 132.341 192.771 184.716 1.00 20.12 ? 169  ARG B CZ  1 
ATOM   2212 N  NH1 . ARG B 1 169 ? 133.283 191.931 184.318 1.00 20.12 ? 169  ARG B NH1 1 
ATOM   2213 N  NH2 . ARG B 1 169 ? 131.738 193.542 183.816 1.00 20.12 ? 169  ARG B NH2 1 
ATOM   2214 N  N   . PHE B 1 170 ? 131.303 187.605 184.235 1.00 31.72 ? 170  PHE B N   1 
ATOM   2215 C  CA  . PHE B 1 170 ? 131.159 187.190 182.842 1.00 31.72 ? 170  PHE B CA  1 
ATOM   2216 C  C   . PHE B 1 170 ? 130.043 186.162 182.686 1.00 31.72 ? 170  PHE B C   1 
ATOM   2217 O  O   . PHE B 1 170 ? 129.273 186.212 181.720 1.00 31.72 ? 170  PHE B O   1 
ATOM   2218 C  CB  . PHE B 1 170 ? 132.493 186.651 182.326 1.00 31.72 ? 170  PHE B CB  1 
ATOM   2219 C  CG  . PHE B 1 170 ? 132.469 186.238 180.883 1.00 31.72 ? 170  PHE B CG  1 
ATOM   2220 C  CD1 . PHE B 1 170 ? 132.484 187.192 179.880 1.00 31.72 ? 170  PHE B CD1 1 
ATOM   2221 C  CD2 . PHE B 1 170 ? 132.473 184.904 180.527 1.00 31.72 ? 170  PHE B CD2 1 
ATOM   2222 C  CE1 . PHE B 1 170 ? 132.473 186.820 178.549 1.00 31.72 ? 170  PHE B CE1 1 
ATOM   2223 C  CE2 . PHE B 1 170 ? 132.468 184.527 179.198 1.00 31.72 ? 170  PHE B CE2 1 
ATOM   2224 C  CZ  . PHE B 1 170 ? 132.466 185.486 178.209 1.00 31.72 ? 170  PHE B CZ  1 
ATOM   2225 N  N   . SER B 1 171 ? 129.945 185.218 183.622 1.00 34.72 ? 171  SER B N   1 
ATOM   2226 C  CA  . SER B 1 171 ? 128.788 184.333 183.738 1.00 34.72 ? 171  SER B CA  1 
ATOM   2227 C  C   . SER B 1 171 ? 128.748 183.246 182.668 1.00 34.72 ? 171  SER B C   1 
ATOM   2228 O  O   . SER B 1 171 ? 127.875 182.374 182.708 1.00 34.72 ? 171  SER B O   1 
ATOM   2229 C  CB  . SER B 1 171 ? 127.493 185.150 183.685 1.00 34.72 ? 171  SER B CB  1 
ATOM   2230 O  OG  . SER B 1 171 ? 127.220 185.602 182.371 1.00 34.72 ? 171  SER B OG  1 
ATOM   2231 N  N   . TRP B 1 172 ? 129.675 183.282 181.709 1.00 39.64 ? 172  TRP B N   1 
ATOM   2232 C  CA  . TRP B 1 172 ? 129.835 182.156 180.795 1.00 39.64 ? 172  TRP B CA  1 
ATOM   2233 C  C   . TRP B 1 172 ? 131.019 181.289 181.199 1.00 39.64 ? 172  TRP B C   1 
ATOM   2234 O  O   . TRP B 1 172 ? 131.045 180.087 180.901 1.00 39.64 ? 172  TRP B O   1 
ATOM   2235 C  CB  . TRP B 1 172 ? 130.004 182.655 179.359 1.00 39.64 ? 172  TRP B CB  1 
ATOM   2236 N  N   . LEU B 1 173 ? 131.998 181.881 181.886 1.00 41.54 ? 173  LEU B N   1 
ATOM   2237 C  CA  . LEU B 1 173 ? 133.053 181.082 182.492 1.00 41.54 ? 173  LEU B CA  1 
ATOM   2238 C  C   . LEU B 1 173 ? 132.465 180.109 183.501 1.00 41.54 ? 173  LEU B C   1 
ATOM   2239 O  O   . LEU B 1 173 ? 133.065 179.072 183.797 1.00 41.54 ? 173  LEU B O   1 
ATOM   2240 C  CB  . LEU B 1 173 ? 134.086 181.992 183.154 1.00 41.54 ? 173  LEU B CB  1 
ATOM   2241 N  N   . SER B 1 174 ? 131.278 180.416 184.026 1.00 39.52 ? 174  SER B N   1 
ATOM   2242 C  CA  . SER B 1 174 ? 130.589 179.472 184.898 1.00 39.52 ? 174  SER B CA  1 
ATOM   2243 C  C   . SER B 1 174 ? 130.292 178.175 184.158 1.00 39.52 ? 174  SER B C   1 
ATOM   2244 O  O   . SER B 1 174 ? 130.434 177.081 184.715 1.00 39.52 ? 174  SER B O   1 
ATOM   2245 C  CB  . SER B 1 174 ? 129.301 180.099 185.431 1.00 39.52 ? 174  SER B CB  1 
ATOM   2246 N  N   . LEU B 1 175 ? 129.868 178.279 182.897 1.00 45.72 ? 175  LEU B N   1 
ATOM   2247 C  CA  . LEU B 1 175 ? 129.634 177.082 182.095 1.00 45.72 ? 175  LEU B CA  1 
ATOM   2248 C  C   . LEU B 1 175 ? 130.948 176.468 181.628 1.00 45.72 ? 175  LEU B C   1 
ATOM   2249 O  O   . LEU B 1 175 ? 131.067 175.242 181.524 1.00 45.72 ? 175  LEU B O   1 
ATOM   2250 C  CB  . LEU B 1 175 ? 128.748 177.421 180.896 1.00 45.72 ? 175  LEU B CB  1 
ATOM   2251 N  N   . LEU B 1 176 ? 131.944 177.306 181.330 1.00 43.77 ? 176  LEU B N   1 
ATOM   2252 C  CA  . LEU B 1 176 ? 133.221 176.789 180.843 1.00 43.77 ? 176  LEU B CA  1 
ATOM   2253 C  C   . LEU B 1 176 ? 133.946 175.978 181.914 1.00 43.77 ? 176  LEU B C   1 
ATOM   2254 O  O   . LEU B 1 176 ? 134.571 174.955 181.611 1.00 43.77 ? 176  LEU B O   1 
ATOM   2255 C  CB  . LEU B 1 176 ? 134.101 177.943 180.364 1.00 43.77 ? 176  LEU B CB  1 
ATOM   2256 N  N   . VAL B 1 177 ? 133.882 176.425 183.169 1.00 42.59 ? 177  VAL B N   1 
ATOM   2257 C  CA  . VAL B 1 177 ? 134.703 175.819 184.218 1.00 42.59 ? 177  VAL B CA  1 
ATOM   2258 C  C   . VAL B 1 177 ? 134.408 174.335 184.388 1.00 42.59 ? 177  VAL B C   1 
ATOM   2259 O  O   . VAL B 1 177 ? 135.360 173.553 184.537 1.00 42.59 ? 177  VAL B O   1 
ATOM   2260 C  CB  . VAL B 1 177 ? 134.536 176.599 185.533 1.00 42.59 ? 177  VAL B CB  1 
ATOM   2261 N  N   . PRO B 1 178 ? 133.153 173.884 184.422 1.00 43.31 ? 178  PRO B N   1 
ATOM   2262 C  CA  . PRO B 1 178 ? 132.920 172.438 184.553 1.00 43.31 ? 178  PRO B CA  1 
ATOM   2263 C  C   . PRO B 1 178 ? 133.626 171.619 183.487 1.00 43.31 ? 178  PRO B C   1 
ATOM   2264 O  O   . PRO B 1 178 ? 134.181 170.559 183.797 1.00 43.31 ? 178  PRO B O   1 
ATOM   2265 C  CB  . PRO B 1 178 ? 131.394 172.324 184.451 1.00 43.31 ? 178  PRO B CB  1 
ATOM   2266 C  CG  . PRO B 1 178 ? 130.880 173.635 184.936 1.00 43.31 ? 178  PRO B CG  1 
ATOM   2267 C  CD  . PRO B 1 178 ? 131.925 174.670 184.623 1.00 43.31 ? 178  PRO B CD  1 
ATOM   2268 N  N   . PHE B 1 179 ? 133.649 172.094 182.240 1.00 42.83 ? 179  PHE B N   1 
ATOM   2269 C  CA  . PHE B 1 179 ? 134.303 171.343 181.172 1.00 42.83 ? 179  PHE B CA  1 
ATOM   2270 C  C   . PHE B 1 179 ? 135.811 171.278 181.387 1.00 42.83 ? 179  PHE B C   1 
ATOM   2271 O  O   . PHE B 1 179 ? 136.430 170.217 181.232 1.00 42.83 ? 179  PHE B O   1 
ATOM   2272 C  CB  . PHE B 1 179 ? 133.979 171.976 179.818 1.00 42.83 ? 179  PHE B CB  1 
ATOM   2273 N  N   . VAL B 1 180 ? 136.423 172.411 181.739 1.00 41.71 ? 180  VAL B N   1 
ATOM   2274 C  CA  . VAL B 1 180 ? 137.865 172.427 181.964 1.00 41.71 ? 180  VAL B CA  1 
ATOM   2275 C  C   . VAL B 1 180 ? 138.229 171.549 183.150 1.00 41.71 ? 180  VAL B C   1 
ATOM   2276 O  O   . VAL B 1 180 ? 139.237 170.833 183.116 1.00 41.71 ? 180  VAL B O   1 
ATOM   2277 C  CB  . VAL B 1 180 ? 138.358 173.873 182.165 1.00 41.71 ? 180  VAL B CB  1 
ATOM   2278 N  N   . GLN B 1 181 ? 137.433 171.601 184.220 1.00 42.49 ? 181  GLN B N   1 
ATOM   2279 C  CA  . GLN B 1 181 ? 137.678 170.745 185.375 1.00 42.49 ? 181  GLN B CA  1 
ATOM   2280 C  C   . GLN B 1 181 ? 137.559 169.276 184.998 1.00 42.49 ? 181  GLN B C   1 
ATOM   2281 O  O   . GLN B 1 181 ? 138.387 168.452 185.403 1.00 42.49 ? 181  GLN B O   1 
ATOM   2282 C  CB  . GLN B 1 181 ? 136.699 171.091 186.496 1.00 42.49 ? 181  GLN B CB  1 
ATOM   2283 N  N   . TRP B 1 182 ? 136.528 168.929 184.225 1.00 41.05 ? 182  TRP B N   1 
ATOM   2284 C  CA  . TRP B 1 182 ? 136.388 167.569 183.721 1.00 41.05 ? 182  TRP B CA  1 
ATOM   2285 C  C   . TRP B 1 182 ? 137.650 167.137 182.988 1.00 41.05 ? 182  TRP B C   1 
ATOM   2286 O  O   . TRP B 1 182 ? 138.216 166.071 183.263 1.00 41.05 ? 182  TRP B O   1 
ATOM   2287 C  CB  . TRP B 1 182 ? 135.172 167.503 182.794 1.00 41.05 ? 182  TRP B CB  1 
ATOM   2288 C  CG  . TRP B 1 182 ? 134.878 166.156 182.216 1.00 41.05 ? 182  TRP B CG  1 
ATOM   2289 C  CD1 . TRP B 1 182 ? 135.374 165.637 181.056 1.00 41.05 ? 182  TRP B CD1 1 
ATOM   2290 C  CD2 . TRP B 1 182 ? 133.984 165.171 182.747 1.00 41.05 ? 182  TRP B CD2 1 
ATOM   2291 N  NE1 . TRP B 1 182 ? 134.861 164.381 180.842 1.00 41.05 ? 182  TRP B NE1 1 
ATOM   2292 C  CE2 . TRP B 1 182 ? 134.003 164.072 181.865 1.00 41.05 ? 182  TRP B CE2 1 
ATOM   2293 C  CE3 . TRP B 1 182 ? 133.176 165.108 183.886 1.00 41.05 ? 182  TRP B CE3 1 
ATOM   2294 C  CZ2 . TRP B 1 182 ? 133.247 162.924 182.087 1.00 41.05 ? 182  TRP B CZ2 1 
ATOM   2295 C  CZ3 . TRP B 1 182 ? 132.427 163.966 184.105 1.00 41.05 ? 182  TRP B CZ3 1 
ATOM   2296 C  CH2 . TRP B 1 182 ? 132.467 162.890 183.210 1.00 41.05 ? 182  TRP B CH2 1 
ATOM   2297 N  N   . PHE B 1 183 ? 138.120 167.977 182.065 1.00 42.66 ? 183  PHE B N   1 
ATOM   2298 C  CA  . PHE B 1 183 ? 139.286 167.622 181.265 1.00 42.66 ? 183  PHE B CA  1 
ATOM   2299 C  C   . PHE B 1 183 ? 140.527 167.438 182.132 1.00 42.66 ? 183  PHE B C   1 
ATOM   2300 O  O   . PHE B 1 183 ? 141.250 166.446 181.982 1.00 42.66 ? 183  PHE B O   1 
ATOM   2301 C  CB  . PHE B 1 183 ? 139.531 168.690 180.200 1.00 42.66 ? 183  PHE B CB  1 
ATOM   2302 C  CG  . PHE B 1 183 ? 140.871 168.586 179.535 1.00 42.66 ? 183  PHE B CG  1 
ATOM   2303 C  CD1 . PHE B 1 183 ? 141.328 167.371 179.055 1.00 42.66 ? 183  PHE B CD1 1 
ATOM   2304 C  CD2 . PHE B 1 183 ? 141.673 169.704 179.384 1.00 42.66 ? 183  PHE B CD2 1 
ATOM   2305 C  CE1 . PHE B 1 183 ? 142.560 167.272 178.444 1.00 42.66 ? 183  PHE B CE1 1 
ATOM   2306 C  CE2 . PHE B 1 183 ? 142.905 169.611 178.773 1.00 42.66 ? 183  PHE B CE2 1 
ATOM   2307 C  CZ  . PHE B 1 183 ? 143.350 168.394 178.301 1.00 42.66 ? 183  PHE B CZ  1 
ATOM   2308 N  N   . VAL B 1 184 ? 140.795 168.376 183.043 1.00 44.11 ? 184  VAL B N   1 
ATOM   2309 C  CA  . VAL B 1 184 ? 142.025 168.289 183.828 1.00 44.11 ? 184  VAL B CA  1 
ATOM   2310 C  C   . VAL B 1 184 ? 141.967 167.095 184.771 1.00 44.11 ? 184  VAL B C   1 
ATOM   2311 O  O   . VAL B 1 184 ? 142.918 166.309 184.855 1.00 44.11 ? 184  VAL B O   1 
ATOM   2312 C  CB  . VAL B 1 184 ? 142.292 169.593 184.605 1.00 44.11 ? 184  VAL B CB  1 
ATOM   2313 C  CG1 . VAL B 1 184 ? 142.784 170.687 183.663 1.00 44.11 ? 184  VAL B CG1 1 
ATOM   2314 C  CG2 . VAL B 1 184 ? 141.084 170.023 185.430 1.00 44.11 ? 184  VAL B CG2 1 
ATOM   2315 N  N   . GLY B 1 185 ? 140.856 166.934 185.492 1.00 46.45 ? 185  GLY B N   1 
ATOM   2316 C  CA  . GLY B 1 185 ? 140.746 165.816 186.413 1.00 46.45 ? 185  GLY B CA  1 
ATOM   2317 C  C   . GLY B 1 185 ? 140.838 164.480 185.705 1.00 46.45 ? 185  GLY B C   1 
ATOM   2318 O  O   . GLY B 1 185 ? 141.396 163.517 186.236 1.00 46.45 ? 185  GLY B O   1 
ATOM   2319 N  N   . LEU B 1 186 ? 140.294 164.405 184.488 1.00 45.70 ? 186  LEU B N   1 
ATOM   2320 C  CA  . LEU B 1 186 ? 140.350 163.154 183.741 1.00 45.70 ? 186  LEU B CA  1 
ATOM   2321 C  C   . LEU B 1 186 ? 141.714 162.943 183.098 1.00 45.70 ? 186  LEU B C   1 
ATOM   2322 O  O   . LEU B 1 186 ? 141.913 161.953 182.384 1.00 45.70 ? 186  LEU B O   1 
ATOM   2323 C  CB  . LEU B 1 186 ? 139.255 163.135 182.673 1.00 45.70 ? 186  LEU B CB  1 
ATOM   2324 N  N   . SER B 1 187 ? 142.666 163.848 183.338 1.00 44.49 ? 187  SER B N   1 
ATOM   2325 C  CA  . SER B 1 187 ? 143.944 163.793 182.639 1.00 44.49 ? 187  SER B CA  1 
ATOM   2326 C  C   . SER B 1 187 ? 145.137 163.866 183.587 1.00 44.49 ? 187  SER B C   1 
ATOM   2327 O  O   . SER B 1 187 ? 145.968 164.774 183.456 1.00 44.49 ? 187  SER B O   1 
ATOM   2328 C  CB  . SER B 1 187 ? 144.022 164.935 181.626 1.00 44.49 ? 187  SER B CB  1 
ATOM   2329 O  OG  . SER B 1 187 ? 144.061 166.192 182.281 1.00 44.49 ? 187  SER B OG  1 
ATOM   2330 N  N   . PRO B 1 188 ? 145.275 162.935 184.540 1.00 47.85 ? 188  PRO B N   1 
ATOM   2331 C  CA  . PRO B 1 188 ? 146.522 162.863 185.315 1.00 47.85 ? 188  PRO B CA  1 
ATOM   2332 C  C   . PRO B 1 188 ? 147.731 162.630 184.424 1.00 47.85 ? 188  PRO B C   1 
ATOM   2333 O  O   . PRO B 1 188 ? 148.811 163.183 184.656 1.00 47.85 ? 188  PRO B O   1 
ATOM   2334 C  CB  . PRO B 1 188 ? 146.260 161.671 186.252 1.00 47.85 ? 188  PRO B CB  1 
ATOM   2335 C  CG  . PRO B 1 188 ? 145.171 160.910 185.511 1.00 47.85 ? 188  PRO B CG  1 
ATOM   2336 C  CD  . PRO B 1 188 ? 144.289 162.040 185.158 1.00 47.85 ? 188  PRO B CD  1 
ATOM   2337 N  N   . THR B 1 189 ? 147.548 161.800 183.395 1.00 46.83 ? 189  THR B N   1 
ATOM   2338 C  CA  . THR B 1 189 ? 148.567 161.558 182.384 1.00 46.83 ? 189  THR B CA  1 
ATOM   2339 C  C   . THR B 1 189 ? 148.059 161.755 180.965 1.00 46.83 ? 189  THR B C   1 
ATOM   2340 O  O   . THR B 1 189 ? 148.875 161.859 180.044 1.00 46.83 ? 189  THR B O   1 
ATOM   2341 C  CB  . THR B 1 189 ? 149.122 160.131 182.510 1.00 46.83 ? 189  THR B CB  1 
ATOM   2342 O  OG1 . THR B 1 189 ? 148.047 159.188 182.421 1.00 46.83 ? 189  THR B OG1 1 
ATOM   2343 C  CG2 . THR B 1 189 ? 149.849 159.951 183.834 1.00 46.83 ? 189  THR B CG2 1 
ATOM   2344 N  N   . VAL B 1 190 ? 146.739 161.807 180.767 1.00 43.15 ? 190  VAL B N   1 
ATOM   2345 C  CA  . VAL B 1 190 ? 146.189 162.034 179.433 1.00 43.15 ? 190  VAL B CA  1 
ATOM   2346 C  C   . VAL B 1 190 ? 146.613 163.401 178.916 1.00 43.15 ? 190  VAL B C   1 
ATOM   2347 O  O   . VAL B 1 190 ? 146.695 163.626 177.702 1.00 43.15 ? 190  VAL B O   1 
ATOM   2348 C  CB  . VAL B 1 190 ? 144.655 161.891 179.456 1.00 43.15 ? 190  VAL B CB  1 
ATOM   2349 C  CG1 . VAL B 1 190 ? 144.087 161.985 178.045 1.00 43.15 ? 190  VAL B CG1 1 
ATOM   2350 C  CG2 . VAL B 1 190 ? 144.248 160.582 180.120 1.00 43.15 ? 190  VAL B CG2 1 
ATOM   2351 N  N   . TRP B 1 191 ? 146.874 164.339 179.831 1.00 41.54 ? 191  TRP B N   1 
ATOM   2352 C  CA  . TRP B 1 191 ? 147.315 165.670 179.424 1.00 41.54 ? 191  TRP B CA  1 
ATOM   2353 C  C   . TRP B 1 191 ? 148.599 165.590 178.609 1.00 41.54 ? 191  TRP B C   1 
ATOM   2354 O  O   . TRP B 1 191 ? 148.739 166.269 177.583 1.00 41.54 ? 191  TRP B O   1 
ATOM   2355 C  CB  . TRP B 1 191 ? 147.515 166.554 180.654 1.00 41.54 ? 191  TRP B CB  1 
ATOM   2356 N  N   . LEU B 1 192 ? 149.540 164.753 179.044 1.00 38.86 ? 192  LEU B N   1 
ATOM   2357 C  CA  . LEU B 1 192 ? 150.782 164.582 178.301 1.00 38.86 ? 192  LEU B CA  1 
ATOM   2358 C  C   . LEU B 1 192 ? 150.506 164.085 176.887 1.00 38.86 ? 192  LEU B C   1 
ATOM   2359 O  O   . LEU B 1 192 ? 151.077 164.590 175.914 1.00 38.86 ? 192  LEU B O   1 
ATOM   2360 C  CB  . LEU B 1 192 ? 151.695 163.612 179.051 1.00 38.86 ? 192  LEU B CB  1 
ATOM   2361 C  CG  . LEU B 1 192 ? 152.992 163.195 178.358 1.00 38.86 ? 192  LEU B CG  1 
ATOM   2362 C  CD1 . LEU B 1 192 ? 154.123 163.123 179.372 1.00 38.86 ? 192  LEU B CD1 1 
ATOM   2363 C  CD2 . LEU B 1 192 ? 152.821 161.859 177.649 1.00 38.86 ? 192  LEU B CD2 1 
ATOM   2364 N  N   . SER B 1 193 ? 149.620 163.094 176.756 1.00 34.28 ? 193  SER B N   1 
ATOM   2365 C  CA  . SER B 1 193 ? 149.335 162.526 175.443 1.00 34.28 ? 193  SER B CA  1 
ATOM   2366 C  C   . SER B 1 193 ? 148.655 163.542 174.535 1.00 34.28 ? 193  SER B C   1 
ATOM   2367 O  O   . SER B 1 193 ? 148.959 163.618 173.338 1.00 34.28 ? 193  SER B O   1 
ATOM   2368 C  CB  . SER B 1 193 ? 148.466 161.278 175.593 1.00 34.28 ? 193  SER B CB  1 
ATOM   2369 O  OG  . SER B 1 193 ? 148.180 160.705 174.331 1.00 34.28 ? 193  SER B OG  1 
ATOM   2370 N  N   . VAL B 1 194 ? 147.719 164.320 175.079 1.00 34.56 ? 194  VAL B N   1 
ATOM   2371 C  CA  . VAL B 1 194 ? 147.041 165.311 174.250 1.00 34.56 ? 194  VAL B CA  1 
ATOM   2372 C  C   . VAL B 1 194 ? 147.995 166.433 173.866 1.00 34.56 ? 194  VAL B C   1 
ATOM   2373 O  O   . VAL B 1 194 ? 147.839 167.042 172.805 1.00 34.56 ? 194  VAL B O   1 
ATOM   2374 C  CB  . VAL B 1 194 ? 145.780 165.852 174.950 1.00 34.56 ? 194  VAL B CB  1 
ATOM   2375 C  CG1 . VAL B 1 194 ? 144.784 164.724 175.189 1.00 34.56 ? 194  VAL B CG1 1 
ATOM   2376 C  CG2 . VAL B 1 194 ? 146.134 166.537 176.247 1.00 34.56 ? 194  VAL B CG2 1 
ATOM   2377 N  N   . ILE B 1 195 ? 148.999 166.727 174.696 1.00 32.21 ? 195  ILE B N   1 
ATOM   2378 C  CA  . ILE B 1 195 ? 150.021 167.682 174.272 1.00 32.21 ? 195  ILE B CA  1 
ATOM   2379 C  C   . ILE B 1 195 ? 150.757 167.159 173.044 1.00 32.21 ? 195  ILE B C   1 
ATOM   2380 O  O   . ILE B 1 195 ? 150.986 167.895 172.073 1.00 32.21 ? 195  ILE B O   1 
ATOM   2381 C  CB  . ILE B 1 195 ? 150.991 167.984 175.430 1.00 32.21 ? 195  ILE B CB  1 
ATOM   2382 C  CG1 . ILE B 1 195 ? 150.270 168.758 176.540 1.00 32.21 ? 195  ILE B CG1 1 
ATOM   2383 C  CG2 . ILE B 1 195 ? 152.200 168.759 174.920 1.00 32.21 ? 195  ILE B CG2 1 
ATOM   2384 C  CD1 . ILE B 1 195 ? 151.051 168.856 177.835 1.00 32.21 ? 195  ILE B CD1 1 
ATOM   2385 N  N   . TRP B 1 196 ? 151.133 165.877 173.065 1.00 29.62 ? 196  TRP B N   1 
ATOM   2386 C  CA  . TRP B 1 196 ? 151.797 165.271 171.914 1.00 29.62 ? 196  TRP B CA  1 
ATOM   2387 C  C   . TRP B 1 196 ? 150.906 165.324 170.682 1.00 29.62 ? 196  TRP B C   1 
ATOM   2388 O  O   . TRP B 1 196 ? 151.360 165.673 169.582 1.00 29.62 ? 196  TRP B O   1 
ATOM   2389 C  CB  . TRP B 1 196 ? 152.162 163.823 172.244 1.00 29.62 ? 196  TRP B CB  1 
ATOM   2390 C  CG  . TRP B 1 196 ? 152.587 163.004 171.063 1.00 29.62 ? 196  TRP B CG  1 
ATOM   2391 C  CD1 . TRP B 1 196 ? 153.814 163.001 170.470 1.00 29.62 ? 196  TRP B CD1 1 
ATOM   2392 C  CD2 . TRP B 1 196 ? 151.783 162.074 170.325 1.00 29.62 ? 196  TRP B CD2 1 
ATOM   2393 N  NE1 . TRP B 1 196 ? 153.829 162.122 169.413 1.00 29.62 ? 196  TRP B NE1 1 
ATOM   2394 C  CE2 . TRP B 1 196 ? 152.592 161.542 169.303 1.00 29.62 ? 196  TRP B CE2 1 
ATOM   2395 C  CE3 . TRP B 1 196 ? 150.458 161.639 170.432 1.00 29.62 ? 196  TRP B CE3 1 
ATOM   2396 C  CZ2 . TRP B 1 196 ? 152.121 160.599 168.395 1.00 29.62 ? 196  TRP B CZ2 1 
ATOM   2397 C  CZ3 . TRP B 1 196 ? 149.992 160.702 169.528 1.00 29.62 ? 196  TRP B CZ3 1 
ATOM   2398 C  CH2 . TRP B 1 196 ? 150.822 160.193 168.524 1.00 29.62 ? 196  TRP B CH2 1 
ATOM   2399 N  N   . MET B 1 197 ? 149.626 164.990 170.853 1.00 28.30 ? 197  MET B N   1 
ATOM   2400 C  CA  . MET B 1 197 ? 148.688 165.041 169.738 1.00 28.30 ? 197  MET B CA  1 
ATOM   2401 C  C   . MET B 1 197 ? 148.583 166.455 169.183 1.00 28.30 ? 197  MET B C   1 
ATOM   2402 O  O   . MET B 1 197 ? 148.600 166.656 167.963 1.00 28.30 ? 197  MET B O   1 
ATOM   2403 C  CB  . MET B 1 197 ? 147.315 164.548 170.192 1.00 28.30 ? 197  MET B CB  1 
ATOM   2404 C  CG  . MET B 1 197 ? 147.272 163.077 170.563 1.00 28.30 ? 197  MET B CG  1 
ATOM   2405 S  SD  . MET B 1 197 ? 145.874 162.668 171.624 1.00 28.30 ? 197  MET B SD  1 
ATOM   2406 C  CE  . MET B 1 197 ? 146.055 160.892 171.748 1.00 28.30 ? 197  MET B CE  1 
ATOM   2407 N  N   . MET B 1 198 ? 148.487 167.446 170.070 1.00 26.71 ? 198  MET B N   1 
ATOM   2408 C  CA  . MET B 1 198 ? 148.366 168.832 169.642 1.00 26.71 ? 198  MET B CA  1 
ATOM   2409 C  C   . MET B 1 198 ? 149.590 169.263 168.848 1.00 26.71 ? 198  MET B C   1 
ATOM   2410 O  O   . MET B 1 198 ? 149.465 169.951 167.830 1.00 26.71 ? 198  MET B O   1 
ATOM   2411 C  CB  . MET B 1 198 ? 148.184 169.734 170.867 1.00 26.71 ? 198  MET B CB  1 
ATOM   2412 C  CG  . MET B 1 198 ? 148.004 171.234 170.591 1.00 26.71 ? 198  MET B CG  1 
ATOM   2413 S  SD  . MET B 1 198 ? 146.851 171.760 169.300 1.00 26.71 ? 198  MET B SD  1 
ATOM   2414 C  CE  . MET B 1 198 ? 145.492 170.606 169.488 1.00 26.71 ? 198  MET B CE  1 
ATOM   2415 N  N   . TRP B 1 199 ? 150.762 168.874 169.365 1.00 21.48 ? 199  TRP B N   1 
ATOM   2416 C  CA  . TRP B 1 199 ? 152.074 169.183 168.780 1.00 21.48 ? 199  TRP B CA  1 
ATOM   2417 C  C   . TRP B 1 199 ? 152.175 168.620 167.373 1.00 21.48 ? 199  TRP B C   1 
ATOM   2418 O  O   . TRP B 1 199 ? 152.652 169.290 166.456 1.00 21.48 ? 199  TRP B O   1 
ATOM   2419 C  CB  . TRP B 1 199 ? 153.195 168.627 169.660 1.00 21.48 ? 199  TRP B CB  1 
ATOM   2420 C  CG  . TRP B 1 199 ? 154.569 168.970 169.172 1.00 21.48 ? 199  TRP B CG  1 
ATOM   2421 C  CD1 . TRP B 1 199 ? 155.032 170.207 168.832 1.00 21.48 ? 199  TRP B CD1 1 
ATOM   2422 C  CD2 . TRP B 1 199 ? 155.665 168.066 168.986 1.00 21.48 ? 199  TRP B CD2 1 
ATOM   2423 N  NE1 . TRP B 1 199 ? 156.346 170.129 168.436 1.00 21.48 ? 199  TRP B NE1 1 
ATOM   2424 C  CE2 . TRP B 1 199 ? 156.758 168.826 168.523 1.00 21.48 ? 199  TRP B CE2 1 
ATOM   2425 C  CE3 . TRP B 1 199 ? 155.828 166.689 169.163 1.00 21.48 ? 199  TRP B CE3 1 
ATOM   2426 C  CZ2 . TRP B 1 199 ? 157.995 168.254 168.234 1.00 21.48 ? 199  TRP B CZ2 1 
ATOM   2427 C  CZ3 . TRP B 1 199 ? 157.057 166.124 168.876 1.00 21.48 ? 199  TRP B CZ3 1 
ATOM   2428 C  CH2 . TRP B 1 199 ? 158.124 166.905 168.417 1.00 21.48 ? 199  TRP B CH2 1 
ATOM   2429 N  N   . TYR B 1 200 ? 151.725 167.383 167.207 1.00 23.92 ? 200  TYR B N   1 
ATOM   2430 C  CA  . TYR B 1 200 ? 151.667 166.773 165.877 1.00 23.92 ? 200  TYR B CA  1 
ATOM   2431 C  C   . TYR B 1 200 ? 150.390 167.100 165.122 1.00 23.92 ? 200  TYR B C   1 
ATOM   2432 O  O   . TYR B 1 200 ? 150.450 167.726 164.059 1.00 23.92 ? 200  TYR B O   1 
ATOM   2433 C  CB  . TYR B 1 200 ? 151.798 165.245 165.954 1.00 23.92 ? 200  TYR B CB  1 
ATOM   2434 C  CG  . TYR B 1 200 ? 153.213 164.730 165.908 1.00 23.92 ? 200  TYR B CG  1 
ATOM   2435 C  CD1 . TYR B 1 200 ? 153.836 164.508 164.688 1.00 23.92 ? 200  TYR B CD1 1 
ATOM   2436 C  CD2 . TYR B 1 200 ? 153.918 164.442 167.065 1.00 23.92 ? 200  TYR B CD2 1 
ATOM   2437 C  CE1 . TYR B 1 200 ? 155.127 164.024 164.621 1.00 23.92 ? 200  TYR B CE1 1 
ATOM   2438 C  CE2 . TYR B 1 200 ? 155.217 163.949 166.999 1.00 23.92 ? 200  TYR B CE2 1 
ATOM   2439 C  CZ  . TYR B 1 200 ? 155.814 163.756 165.780 1.00 23.92 ? 200  TYR B CZ  1 
ATOM   2440 O  OH  . TYR B 1 200 ? 157.101 163.270 165.737 1.00 23.92 ? 200  TYR B OH  1 
ATOM   2441 N  N   . TRP B 1 201 ? 149.229 166.681 165.628 1.00 22.14 ? 201  TRP B N   1 
ATOM   2442 C  CA  . TRP B 1 201 ? 148.008 166.781 164.842 1.00 22.14 ? 201  TRP B CA  1 
ATOM   2443 C  C   . TRP B 1 201 ? 147.379 168.163 164.899 1.00 22.14 ? 201  TRP B C   1 
ATOM   2444 O  O   . TRP B 1 201 ? 146.605 168.513 164.001 1.00 22.14 ? 201  TRP B O   1 
ATOM   2445 C  CB  . TRP B 1 201 ? 146.978 165.760 165.323 1.00 22.14 ? 201  TRP B CB  1 
ATOM   2446 C  CG  . TRP B 1 201 ? 147.291 164.343 164.972 1.00 22.14 ? 201  TRP B CG  1 
ATOM   2447 C  CD1 . TRP B 1 201 ? 148.260 163.895 164.126 1.00 22.14 ? 201  TRP B CD1 1 
ATOM   2448 C  CD2 . TRP B 1 201 ? 146.626 163.180 165.470 1.00 22.14 ? 201  TRP B CD2 1 
ATOM   2449 N  NE1 . TRP B 1 201 ? 148.237 162.525 164.063 1.00 22.14 ? 201  TRP B NE1 1 
ATOM   2450 C  CE2 . TRP B 1 201 ? 147.242 162.062 164.881 1.00 22.14 ? 201  TRP B CE2 1 
ATOM   2451 C  CE3 . TRP B 1 201 ? 145.568 162.977 166.359 1.00 22.14 ? 201  TRP B CE3 1 
ATOM   2452 C  CZ2 . TRP B 1 201 ? 146.835 160.760 165.151 1.00 22.14 ? 201  TRP B CZ2 1 
ATOM   2453 C  CZ3 . TRP B 1 201 ? 145.165 161.685 166.625 1.00 22.14 ? 201  TRP B CZ3 1 
ATOM   2454 C  CH2 . TRP B 1 201 ? 145.796 160.593 166.024 1.00 22.14 ? 201  TRP B CH2 1 
ATOM   2455 N  N   . GLY B 1 202 ? 147.694 168.958 165.930 1.00 23.02 ? 202  GLY B N   1 
ATOM   2456 C  CA  . GLY B 1 202 ? 147.018 170.215 166.148 1.00 23.02 ? 202  GLY B CA  1 
ATOM   2457 C  C   . GLY B 1 202 ? 147.029 171.157 164.968 1.00 23.02 ? 202  GLY B C   1 
ATOM   2458 O  O   . GLY B 1 202 ? 145.967 171.652 164.570 1.00 23.02 ? 202  GLY B O   1 
ATOM   2459 N  N   . PRO B 1 203 ? 148.188 171.447 164.375 1.00 14.89 ? 203  PRO B N   1 
ATOM   2460 C  CA  . PRO B 1 203 ? 148.170 172.194 163.110 1.00 14.89 ? 203  PRO B CA  1 
ATOM   2461 C  C   . PRO B 1 203 ? 147.438 171.454 162.007 1.00 14.89 ? 203  PRO B C   1 
ATOM   2462 O  O   . PRO B 1 203 ? 146.766 172.085 161.184 1.00 14.89 ? 203  PRO B O   1 
ATOM   2463 C  CB  . PRO B 1 203 ? 149.659 172.386 162.790 1.00 14.89 ? 203  PRO B CB  1 
ATOM   2464 C  CG  . PRO B 1 203 ? 150.372 172.149 164.082 1.00 14.89 ? 203  PRO B CG  1 
ATOM   2465 C  CD  . PRO B 1 203 ? 149.555 171.164 164.837 1.00 14.89 ? 203  PRO B CD  1 
ATOM   2466 N  N   . SER B 1 204 ? 147.530 170.124 161.975 1.00 19.41 ? 204  SER B N   1 
ATOM   2467 C  CA  . SER B 1 204 ? 146.855 169.358 160.933 1.00 19.41 ? 204  SER B CA  1 
ATOM   2468 C  C   . SER B 1 204 ? 145.340 169.446 161.084 1.00 19.41 ? 204  SER B C   1 
ATOM   2469 O  O   . SER B 1 204 ? 144.618 169.731 160.120 1.00 19.41 ? 204  SER B O   1 
ATOM   2470 C  CB  . SER B 1 204 ? 147.318 167.901 160.976 1.00 19.41 ? 204  SER B CB  1 
ATOM   2471 O  OG  . SER B 1 204 ? 148.689 167.796 160.637 1.00 19.41 ? 204  SER B OG  1 
ATOM   2472 N  N   . LEU B 1 205 ? 144.838 169.186 162.292 1.00 20.15 ? 205  LEU B N   1 
ATOM   2473 C  CA  . LEU B 1 205 ? 143.405 169.303 162.529 1.00 20.15 ? 205  LEU B CA  1 
ATOM   2474 C  C   . LEU B 1 205 ? 142.931 170.727 162.292 1.00 20.15 ? 205  LEU B C   1 
ATOM   2475 O  O   . LEU B 1 205 ? 141.821 170.940 161.793 1.00 20.15 ? 205  LEU B O   1 
ATOM   2476 C  CB  . LEU B 1 205 ? 143.069 168.856 163.953 1.00 20.15 ? 205  LEU B CB  1 
ATOM   2477 C  CG  . LEU B 1 205 ? 141.590 168.859 164.343 1.00 20.15 ? 205  LEU B CG  1 
ATOM   2478 C  CD1 . LEU B 1 205 ? 140.792 167.900 163.477 1.00 20.15 ? 205  LEU B CD1 1 
ATOM   2479 C  CD2 . LEU B 1 205 ? 141.438 168.508 165.816 1.00 20.15 ? 205  LEU B CD2 1 
ATOM   2480 N  N   . TYR B 1 206 ? 143.759 171.715 162.637 1.00 22.24 ? 206  TYR B N   1 
ATOM   2481 C  CA  . TYR B 1 206 ? 143.424 173.095 162.326 1.00 22.24 ? 206  TYR B CA  1 
ATOM   2482 C  C   . TYR B 1 206 ? 143.310 173.321 160.828 1.00 22.24 ? 206  TYR B C   1 
ATOM   2483 O  O   . TYR B 1 206 ? 142.386 174.008 160.388 1.00 22.24 ? 206  TYR B O   1 
ATOM   2484 C  CB  . TYR B 1 206 ? 144.474 174.039 162.917 1.00 22.24 ? 206  TYR B CB  1 
ATOM   2485 C  CG  . TYR B 1 206 ? 144.037 175.487 162.962 1.00 22.24 ? 206  TYR B CG  1 
ATOM   2486 C  CD1 . TYR B 1 206 ? 143.947 176.244 161.801 1.00 22.24 ? 206  TYR B CD1 1 
ATOM   2487 C  CD2 . TYR B 1 206 ? 143.709 176.093 164.165 1.00 22.24 ? 206  TYR B CD2 1 
ATOM   2488 C  CE1 . TYR B 1 206 ? 143.546 177.564 161.839 1.00 22.24 ? 206  TYR B CE1 1 
ATOM   2489 C  CE2 . TYR B 1 206 ? 143.306 177.414 164.213 1.00 22.24 ? 206  TYR B CE2 1 
ATOM   2490 C  CZ  . TYR B 1 206 ? 143.226 178.145 163.047 1.00 22.24 ? 206  TYR B CZ  1 
ATOM   2491 O  OH  . TYR B 1 206 ? 142.825 179.460 163.090 1.00 22.24 ? 206  TYR B OH  1 
ATOM   2492 N  N   . SER B 1 207 ? 144.217 172.753 160.040 1.00 20.16 ? 207  SER B N   1 
ATOM   2493 C  CA  . SER B 1 207 ? 144.163 172.845 158.589 1.00 20.16 ? 207  SER B CA  1 
ATOM   2494 C  C   . SER B 1 207 ? 142.921 172.189 158.008 1.00 20.16 ? 207  SER B C   1 
ATOM   2495 O  O   . SER B 1 207 ? 142.344 172.723 157.057 1.00 20.16 ? 207  SER B O   1 
ATOM   2496 C  CB  . SER B 1 207 ? 145.407 172.198 157.975 1.00 20.16 ? 207  SER B CB  1 
ATOM   2497 O  OG  . SER B 1 207 ? 145.313 170.786 158.026 1.00 20.16 ? 207  SER B OG  1 
ATOM   2498 N  N   . ILE B 1 208 ? 142.508 171.045 158.544 1.00 22.36 ? 208  ILE B N   1 
ATOM   2499 C  CA  . ILE B 1 208 ? 141.298 170.370 158.088 1.00 22.36 ? 208  ILE B CA  1 
ATOM   2500 C  C   . ILE B 1 208 ? 140.043 171.148 158.470 1.00 22.36 ? 208  ILE B C   1 
ATOM   2501 O  O   . ILE B 1 208 ? 139.098 171.228 157.685 1.00 22.36 ? 208  ILE B O   1 
ATOM   2502 C  CB  . ILE B 1 208 ? 141.241 168.924 158.628 1.00 22.36 ? 208  ILE B CB  1 
ATOM   2503 C  CG1 . ILE B 1 208 ? 142.534 168.171 158.312 1.00 22.36 ? 208  ILE B CG1 1 
ATOM   2504 C  CG2 . ILE B 1 208 ? 140.057 168.177 158.036 1.00 22.36 ? 208  ILE B CG2 1 
ATOM   2505 C  CD1 . ILE B 1 208 ? 143.025 168.343 156.893 1.00 22.36 ? 208  ILE B CD1 1 
ATOM   2506 N  N   . LEU B 1 209 ? 140.009 171.724 159.673 1.00 24.62 ? 209  LEU B N   1 
ATOM   2507 C  CA  . LEU B 1 209 ? 138.832 172.479 160.089 1.00 24.62 ? 209  LEU B CA  1 
ATOM   2508 C  C   . LEU B 1 209 ? 138.761 173.842 159.411 1.00 24.62 ? 209  LEU B C   1 
ATOM   2509 O  O   . LEU B 1 209 ? 137.666 174.391 159.246 1.00 24.62 ? 209  LEU B O   1 
ATOM   2510 C  CB  . LEU B 1 209 ? 138.829 172.644 161.610 1.00 24.62 ? 209  LEU B CB  1 
ATOM   2511 C  CG  . LEU B 1 209 ? 137.834 173.647 162.207 1.00 24.62 ? 209  LEU B CG  1 
ATOM   2512 C  CD1 . LEU B 1 209 ? 136.402 173.206 161.947 1.00 24.62 ? 209  LEU B CD1 1 
ATOM   2513 C  CD2 . LEU B 1 209 ? 138.078 173.827 163.700 1.00 24.62 ? 209  LEU B CD2 1 
ATOM   2514 N  N   . SER B 1 210 ? 139.902 174.404 159.015 1.00 24.82 ? 210  SER B N   1 
ATOM   2515 C  CA  . SER B 1 210 ? 139.914 175.782 158.535 1.00 24.82 ? 210  SER B CA  1 
ATOM   2516 C  C   . SER B 1 210 ? 139.042 176.003 157.307 1.00 24.82 ? 210  SER B C   1 
ATOM   2517 O  O   . SER B 1 210 ? 138.308 177.006 157.283 1.00 24.82 ? 210  SER B O   1 
ATOM   2518 C  CB  . SER B 1 210 ? 141.361 176.211 158.267 1.00 24.82 ? 210  SER B CB  1 
ATOM   2519 O  OG  . SER B 1 210 ? 142.088 176.298 159.480 1.00 24.82 ? 210  SER B OG  1 
ATOM   2520 N  N   . PRO B 1 211 ? 139.064 175.154 156.276 1.00 27.15 ? 211  PRO B N   1 
ATOM   2521 C  CA  . PRO B 1 211 ? 138.134 175.371 155.156 1.00 27.15 ? 211  PRO B CA  1 
ATOM   2522 C  C   . PRO B 1 211 ? 136.686 175.453 155.600 1.00 27.15 ? 211  PRO B C   1 
ATOM   2523 O  O   . PRO B 1 211 ? 135.903 176.215 155.020 1.00 27.15 ? 211  PRO B O   1 
ATOM   2524 C  CB  . PRO B 1 211 ? 138.389 174.159 154.255 1.00 27.15 ? 211  PRO B CB  1 
ATOM   2525 C  CG  . PRO B 1 211 ? 139.788 173.774 154.537 1.00 27.15 ? 211  PRO B CG  1 
ATOM   2526 C  CD  . PRO B 1 211 ? 140.050 174.104 155.978 1.00 27.15 ? 211  PRO B CD  1 
ATOM   2527 N  N   . PHE B 1 212 ? 136.306 174.679 156.618 1.00 27.54 ? 212  PHE B N   1 
ATOM   2528 C  CA  . PHE B 1 212 ? 134.964 174.792 157.176 1.00 27.54 ? 212  PHE B CA  1 
ATOM   2529 C  C   . PHE B 1 212 ? 134.919 175.811 158.303 1.00 27.54 ? 212  PHE B C   1 
ATOM   2530 O  O   . PHE B 1 212 ? 133.865 176.012 158.916 1.00 27.54 ? 212  PHE B O   1 
ATOM   2531 C  CB  . PHE B 1 212 ? 134.497 173.423 157.660 1.00 27.54 ? 212  PHE B CB  1 
ATOM   2532 C  CG  . PHE B 1 212 ? 134.735 172.331 156.664 1.00 27.54 ? 212  PHE B CG  1 
ATOM   2533 C  CD1 . PHE B 1 212 ? 133.810 172.071 155.670 1.00 27.54 ? 212  PHE B CD1 1 
ATOM   2534 C  CD2 . PHE B 1 212 ? 135.900 171.586 156.700 1.00 27.54 ? 212  PHE B CD2 1 
ATOM   2535 C  CE1 . PHE B 1 212 ? 134.031 171.076 154.745 1.00 27.54 ? 212  PHE B CE1 1 
ATOM   2536 C  CE2 . PHE B 1 212 ? 136.127 170.591 155.777 1.00 27.54 ? 212  PHE B CE2 1 
ATOM   2537 C  CZ  . PHE B 1 212 ? 135.191 170.335 154.798 1.00 27.54 ? 212  PHE B CZ  1 
ATOM   2538 N  N   . LEU B 1 213 ? 136.050 176.453 158.593 1.00 27.42 ? 213  LEU B N   1 
ATOM   2539 C  CA  . LEU B 1 213 ? 136.072 177.516 159.595 1.00 27.42 ? 213  LEU B CA  1 
ATOM   2540 C  C   . LEU B 1 213 ? 135.121 178.654 159.258 1.00 27.42 ? 213  LEU B C   1 
ATOM   2541 O  O   . LEU B 1 213 ? 134.444 179.148 160.174 1.00 27.42 ? 213  LEU B O   1 
ATOM   2542 C  CB  . LEU B 1 213 ? 137.504 178.031 159.765 1.00 27.42 ? 213  LEU B CB  1 
ATOM   2543 N  N   . PRO B 1 214 ? 135.017 179.126 158.009 1.00 30.17 ? 214  PRO B N   1 
ATOM   2544 C  CA  . PRO B 1 214 ? 134.091 180.235 157.746 1.00 30.17 ? 214  PRO B CA  1 
ATOM   2545 C  C   . PRO B 1 214 ? 132.654 179.793 157.532 1.00 30.17 ? 214  PRO B C   1 
ATOM   2546 O  O   . PRO B 1 214 ? 131.729 180.571 157.794 1.00 30.17 ? 214  PRO B O   1 
ATOM   2547 C  CB  . PRO B 1 214 ? 134.704 180.885 156.499 1.00 30.17 ? 214  PRO B CB  1 
ATOM   2548 C  CG  . PRO B 1 214 ? 135.467 179.752 155.799 1.00 30.17 ? 214  PRO B CG  1 
ATOM   2549 C  CD  . PRO B 1 214 ? 135.488 178.557 156.736 1.00 30.17 ? 214  PRO B CD  1 
ATOM   2550 N  N   . LEU B 1 215 ? 132.433 178.562 157.067 1.00 35.71 ? 215  LEU B N   1 
ATOM   2551 C  CA  . LEU B 1 215 ? 131.087 178.007 157.103 1.00 35.71 ? 215  LEU B CA  1 
ATOM   2552 C  C   . LEU B 1 215 ? 130.632 177.788 158.537 1.00 35.71 ? 215  LEU B C   1 
ATOM   2553 O  O   . LEU B 1 215 ? 129.430 177.664 158.796 1.00 35.71 ? 215  LEU B O   1 
ATOM   2554 C  CB  . LEU B 1 215 ? 131.033 176.695 156.320 1.00 35.71 ? 215  LEU B CB  1 
ATOM   2555 N  N   . LEU B 1 216 ? 131.579 177.729 159.481 1.00 37.36 ? 216  LEU B N   1 
ATOM   2556 C  CA  . LEU B 1 216 ? 131.200 177.570 160.884 1.00 37.36 ? 216  LEU B CA  1 
ATOM   2557 C  C   . LEU B 1 216 ? 130.375 178.748 161.376 1.00 37.36 ? 216  LEU B C   1 
ATOM   2558 O  O   . LEU B 1 216 ? 129.304 178.522 161.966 1.00 37.36 ? 216  LEU B O   1 
ATOM   2559 C  CB  . LEU B 1 216 ? 132.453 177.357 161.738 1.00 37.36 ? 216  LEU B CB  1 
ATOM   2560 N  N   . PRO B 1 217 ? 130.794 180.002 161.192 1.00 34.36 ? 217  PRO B N   1 
ATOM   2561 C  CA  . PRO B 1 217 ? 129.916 181.116 161.578 1.00 34.36 ? 217  PRO B CA  1 
ATOM   2562 C  C   . PRO B 1 217 ? 128.572 181.113 160.872 1.00 34.36 ? 217  PRO B C   1 
ATOM   2563 O  O   . PRO B 1 217 ? 127.585 181.557 161.461 1.00 34.36 ? 217  PRO B O   1 
ATOM   2564 C  CB  . PRO B 1 217 ? 130.751 182.348 161.213 1.00 34.36 ? 217  PRO B CB  1 
ATOM   2565 C  CG  . PRO B 1 217 ? 132.148 181.902 161.399 1.00 34.36 ? 217  PRO B CG  1 
ATOM   2566 C  CD  . PRO B 1 217 ? 132.183 180.450 161.006 1.00 34.36 ? 217  PRO B CD  1 
ATOM   2567 N  N   . ILE B 1 218 ? 128.491 180.628 159.631 1.00 36.73 ? 218  ILE B N   1 
ATOM   2568 C  CA  . ILE B 1 218 ? 127.212 180.673 158.924 1.00 36.73 ? 218  ILE B CA  1 
ATOM   2569 C  C   . ILE B 1 218 ? 126.173 179.811 159.634 1.00 36.73 ? 218  ILE B C   1 
ATOM   2570 O  O   . ILE B 1 218 ? 125.073 180.280 159.962 1.00 36.73 ? 218  ILE B O   1 
ATOM   2571 C  CB  . ILE B 1 218 ? 127.395 180.252 157.453 1.00 36.73 ? 218  ILE B CB  1 
ATOM   2572 C  CG1 . ILE B 1 218 ? 128.314 181.245 156.735 1.00 36.73 ? 218  ILE B CG1 1 
ATOM   2573 C  CG2 . ILE B 1 218 ? 126.046 180.159 156.749 1.00 36.73 ? 218  ILE B CG2 1 
ATOM   2574 C  CD1 . ILE B 1 218 ? 128.771 180.798 155.358 1.00 36.73 ? 218  ILE B CD1 1 
ATOM   2575 N  N   . PHE B 1 219 ? 126.503 178.549 159.917 1.00 38.38 ? 219  PHE B N   1 
ATOM   2576 C  CA  . PHE B 1 219 ? 125.522 177.713 160.598 1.00 38.38 ? 219  PHE B CA  1 
ATOM   2577 C  C   . PHE B 1 219 ? 125.481 177.983 162.095 1.00 38.38 ? 219  PHE B C   1 
ATOM   2578 O  O   . PHE B 1 219 ? 124.485 177.649 162.738 1.00 38.38 ? 219  PHE B O   1 
ATOM   2579 C  CB  . PHE B 1 219 ? 125.764 176.226 160.303 1.00 38.38 ? 219  PHE B CB  1 
ATOM   2580 C  CG  . PHE B 1 219 ? 127.032 175.662 160.881 1.00 38.38 ? 219  PHE B CG  1 
ATOM   2581 C  CD1 . PHE B 1 219 ? 127.181 175.483 162.243 1.00 38.38 ? 219  PHE B CD1 1 
ATOM   2582 C  CD2 . PHE B 1 219 ? 128.052 175.251 160.043 1.00 38.38 ? 219  PHE B CD2 1 
ATOM   2583 C  CE1 . PHE B 1 219 ? 128.341 174.946 162.760 1.00 38.38 ? 219  PHE B CE1 1 
ATOM   2584 C  CE2 . PHE B 1 219 ? 129.207 174.706 160.553 1.00 38.38 ? 219  PHE B CE2 1 
ATOM   2585 C  CZ  . PHE B 1 219 ? 129.355 174.557 161.914 1.00 38.38 ? 219  PHE B CZ  1 
ATOM   2586 N  N   . PHE B 1 220 ? 126.510 178.616 162.661 1.00 35.64 ? 220  PHE B N   1 
ATOM   2587 C  CA  . PHE B 1 220 ? 126.376 179.142 164.015 1.00 35.64 ? 220  PHE B CA  1 
ATOM   2588 C  C   . PHE B 1 220 ? 125.310 180.229 164.062 1.00 35.64 ? 220  PHE B C   1 
ATOM   2589 O  O   . PHE B 1 220 ? 124.495 180.276 164.991 1.00 35.64 ? 220  PHE B O   1 
ATOM   2590 C  CB  . PHE B 1 220 ? 127.719 179.683 164.504 1.00 35.64 ? 220  PHE B CB  1 
ATOM   2591 N  N   . CYS B 1 221 ? 125.300 181.102 163.055 1.00 35.16 ? 221  CYS B N   1 
ATOM   2592 C  CA  . CYS B 1 221 ? 124.249 182.101 162.922 1.00 35.16 ? 221  CYS B CA  1 
ATOM   2593 C  C   . CYS B 1 221 ? 122.893 181.441 162.720 1.00 35.16 ? 221  CYS B C   1 
ATOM   2594 O  O   . CYS B 1 221 ? 121.887 181.877 163.292 1.00 35.16 ? 221  CYS B O   1 
ATOM   2595 C  CB  . CYS B 1 221 ? 124.574 183.023 161.749 1.00 35.16 ? 221  CYS B CB  1 
ATOM   2596 N  N   . LEU B 1 222 ? 122.847 180.394 161.894 1.00 35.92 ? 222  LEU B N   1 
ATOM   2597 C  CA  . LEU B 1 222 ? 121.600 179.658 161.713 1.00 35.92 ? 222  LEU B CA  1 
ATOM   2598 C  C   . LEU B 1 222 ? 121.103 179.088 163.037 1.00 35.92 ? 222  LEU B C   1 
ATOM   2599 O  O   . LEU B 1 222 ? 119.906 179.151 163.341 1.00 35.92 ? 222  LEU B O   1 
ATOM   2600 C  CB  . LEU B 1 222 ? 121.795 178.540 160.689 1.00 35.92 ? 222  LEU B CB  1 
ATOM   2601 N  N   . TRP B 1 223 ? 122.011 178.524 163.837 1.00 36.39 ? 223  TRP B N   1 
ATOM   2602 C  CA  . TRP B 1 223 ? 121.637 177.994 165.144 1.00 36.39 ? 223  TRP B CA  1 
ATOM   2603 C  C   . TRP B 1 223 ? 121.127 179.103 166.055 1.00 36.39 ? 223  TRP B C   1 
ATOM   2604 O  O   . TRP B 1 223 ? 120.140 178.927 166.778 1.00 36.39 ? 223  TRP B O   1 
ATOM   2605 C  CB  . TRP B 1 223 ? 122.833 177.285 165.779 1.00 36.39 ? 223  TRP B CB  1 
ATOM   2606 N  N   . VAL B 1 224 ? 121.798 180.256 166.037 1.00 36.66 ? 224  VAL B N   1 
ATOM   2607 C  CA  . VAL B 1 224 ? 121.369 181.377 166.867 1.00 36.66 ? 224  VAL B CA  1 
ATOM   2608 C  C   . VAL B 1 224 ? 119.977 181.845 166.464 1.00 36.66 ? 224  VAL B C   1 
ATOM   2609 O  O   . VAL B 1 224 ? 119.167 182.216 167.321 1.00 36.66 ? 224  VAL B O   1 
ATOM   2610 C  CB  . VAL B 1 224 ? 122.391 182.525 166.781 1.00 36.66 ? 224  VAL B CB  1 
ATOM   2611 N  N   . TYR B 1 225 ? 119.675 181.841 165.163 1.00 35.54 ? 225  TYR B N   1 
ATOM   2612 C  CA  . TYR B 1 225 ? 118.344 182.237 164.715 1.00 35.54 ? 225  TYR B CA  1 
ATOM   2613 C  C   . TYR B 1 225 ? 117.278 181.297 165.262 1.00 35.54 ? 225  TYR B C   1 
ATOM   2614 O  O   . TYR B 1 225 ? 116.209 181.743 165.695 1.00 35.54 ? 225  TYR B O   1 
ATOM   2615 C  CB  . TYR B 1 225 ? 118.295 182.273 163.188 1.00 35.54 ? 225  TYR B CB  1 
ATOM   2616 N  N   . ILE B 1 226 ? 117.545 179.994 165.246 1.00 41.72 ? 226  ILE B N   1 
ATOM   2617 C  CA  . ILE B 1 226 ? 116.617 179.016 165.802 1.00 41.72 ? 226  ILE B CA  1 
ATOM   2618 C  C   . ILE B 1 226 ? 116.797 178.998 167.320 1.00 41.72 ? 226  ILE B C   1 
ATOM   2619 O  O   . ILE B 1 226 ? 117.062 177.975 167.950 1.00 41.72 ? 226  ILE B O   1 
ATOM   2620 C  CB  . ILE B 1 226 ? 116.825 177.611 165.165 1.00 41.72 ? 226  ILE B CB  1 
ATOM   2621 C  CG1 . ILE B 1 226 ? 115.798 176.599 165.690 1.00 41.72 ? 226  ILE B CG1 1 
ATOM   2622 C  CG2 . ILE B 1 226 ? 118.240 177.104 165.401 1.00 41.72 ? 226  ILE B CG2 1 
ATOM   2623 C  CD1 . ILE B 1 226 ? 114.376 176.895 165.275 1.00 41.72 ? 226  ILE B CD1 1 
ATOM   2624 O  OXT . ILE B 1 226 ? 116.684 180.040 167.965 1.00 41.72 ? 226  ILE B OXT 1 
HETATM 2625 ZN ZN  . ZN  C 2 .   ? 156.912 178.753 154.457 1.00 52.31 ? 1001 ZN  A ZN  1 
HETATM 2626 ZN ZN  . ZN  D 2 .   ? 173.115 192.470 160.540 1.00 2.60  ? 301  ZN  B ZN  1 
# 
