data_9IWK
# 
_entry.id   9IWK 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9IWK         pdb_00009iwk 10.2210/pdb9iwk/pdb 
WWPDB D_1300049633 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-05-07 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9IWK 
_pdbx_database_status.recvd_initial_deposition_date   2024-07-25 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              isao-ishii@umin.ac.jp 
_pdbx_contact_author.name_first         Isao 
_pdbx_contact_author.name_last          Ishii 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-5367-205X 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Kamata, S.'   1  0000-0002-2400-6533 
'Honda, A.'    2  ?                   
'Masuda, R.'   3  ?                   
'Oota, M.'     4  ?                   
'Namatame, R.' 5  ?                   
'Machida, Y.'  6  ?                   
'Uchii, K.'    7  ?                   
'Shiiyama, Y.' 8  ?                   
'Oyama, T.'    9  0000-0002-3411-7608 
'Ishii, I.'    10 0000-0002-5367-205X 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   CH 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Antioxidants 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2076-3921 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            14 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
;Competitive Ligand-Induced Recruitment of Coactivators to Specific PPAR alpha / delta / gamma Ligand-Binding Domains Revealed by Dual-Emission FRET and X-Ray Diffraction of Cocrystals.
;
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.3390/antiox14040494 
_citation.pdbx_database_id_PubMed   40298866 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Kamata, S.'    1 0000-0002-2400-6533 
primary 'Honda, A.'     2 ?                   
primary 'Yashiro, S.'   3 ?                   
primary 'Kaneko, C.'    4 ?                   
primary 'Komori, Y.'    5 ?                   
primary 'Shimamura, A.' 6 ?                   
primary 'Masuda, R.'    7 ?                   
primary 'Oyama, T.'     8 0000-0002-3411-7608 
primary 'Ishii, I.'     9 0000-0002-5367-205X 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'Isoform 1 of Peroxisome proliferator-activated receptor gamma' 31862.994 2 ? ? ?                        ? 
2 polymer syn 'Nuclear receptor corepressor 2'                                2599.999  2 ? ? 'UNP residues 2346-2367' ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 PPAR-gamma 
2 
;N-CoR2,CTG repeat protein 26,SMAP270,Silencing mediator of retinoic acid and thyroid hormone receptor,SMRT,T3 receptor-associating factor,TRAC,Thyroid-,retinoic-acid-receptor-associated corepressor
;
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;GSHMQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVA
IRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRK
PFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQK
MTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
;
;GSHMQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVA
IRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRK
PFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQK
MTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
;
A,C ? 
2 'polypeptide(L)' no no TNMGLEAIIRKALMGKYDQWEE TNMGLEAIIRKALMGKYDQWEE B,D ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   SER n 
1 3   HIS n 
1 4   MET n 
1 5   GLN n 
1 6   LEU n 
1 7   ASN n 
1 8   PRO n 
1 9   GLU n 
1 10  SER n 
1 11  ALA n 
1 12  ASP n 
1 13  LEU n 
1 14  ARG n 
1 15  ALA n 
1 16  LEU n 
1 17  ALA n 
1 18  LYS n 
1 19  HIS n 
1 20  LEU n 
1 21  TYR n 
1 22  ASP n 
1 23  SER n 
1 24  TYR n 
1 25  ILE n 
1 26  LYS n 
1 27  SER n 
1 28  PHE n 
1 29  PRO n 
1 30  LEU n 
1 31  THR n 
1 32  LYS n 
1 33  ALA n 
1 34  LYS n 
1 35  ALA n 
1 36  ARG n 
1 37  ALA n 
1 38  ILE n 
1 39  LEU n 
1 40  THR n 
1 41  GLY n 
1 42  LYS n 
1 43  THR n 
1 44  THR n 
1 45  ASP n 
1 46  LYS n 
1 47  SER n 
1 48  PRO n 
1 49  PHE n 
1 50  VAL n 
1 51  ILE n 
1 52  TYR n 
1 53  ASP n 
1 54  MET n 
1 55  ASN n 
1 56  SER n 
1 57  LEU n 
1 58  MET n 
1 59  MET n 
1 60  GLY n 
1 61  GLU n 
1 62  ASP n 
1 63  LYS n 
1 64  ILE n 
1 65  LYS n 
1 66  PHE n 
1 67  LYS n 
1 68  HIS n 
1 69  ILE n 
1 70  THR n 
1 71  PRO n 
1 72  LEU n 
1 73  GLN n 
1 74  GLU n 
1 75  GLN n 
1 76  SER n 
1 77  LYS n 
1 78  GLU n 
1 79  VAL n 
1 80  ALA n 
1 81  ILE n 
1 82  ARG n 
1 83  ILE n 
1 84  PHE n 
1 85  GLN n 
1 86  GLY n 
1 87  CYS n 
1 88  GLN n 
1 89  PHE n 
1 90  ARG n 
1 91  SER n 
1 92  VAL n 
1 93  GLU n 
1 94  ALA n 
1 95  VAL n 
1 96  GLN n 
1 97  GLU n 
1 98  ILE n 
1 99  THR n 
1 100 GLU n 
1 101 TYR n 
1 102 ALA n 
1 103 LYS n 
1 104 SER n 
1 105 ILE n 
1 106 PRO n 
1 107 GLY n 
1 108 PHE n 
1 109 VAL n 
1 110 ASN n 
1 111 LEU n 
1 112 ASP n 
1 113 LEU n 
1 114 ASN n 
1 115 ASP n 
1 116 GLN n 
1 117 VAL n 
1 118 THR n 
1 119 LEU n 
1 120 LEU n 
1 121 LYS n 
1 122 TYR n 
1 123 GLY n 
1 124 VAL n 
1 125 HIS n 
1 126 GLU n 
1 127 ILE n 
1 128 ILE n 
1 129 TYR n 
1 130 THR n 
1 131 MET n 
1 132 LEU n 
1 133 ALA n 
1 134 SER n 
1 135 LEU n 
1 136 MET n 
1 137 ASN n 
1 138 LYS n 
1 139 ASP n 
1 140 GLY n 
1 141 VAL n 
1 142 LEU n 
1 143 ILE n 
1 144 SER n 
1 145 GLU n 
1 146 GLY n 
1 147 GLN n 
1 148 GLY n 
1 149 PHE n 
1 150 MET n 
1 151 THR n 
1 152 ARG n 
1 153 GLU n 
1 154 PHE n 
1 155 LEU n 
1 156 LYS n 
1 157 SER n 
1 158 LEU n 
1 159 ARG n 
1 160 LYS n 
1 161 PRO n 
1 162 PHE n 
1 163 GLY n 
1 164 ASP n 
1 165 PHE n 
1 166 MET n 
1 167 GLU n 
1 168 PRO n 
1 169 LYS n 
1 170 PHE n 
1 171 GLU n 
1 172 PHE n 
1 173 ALA n 
1 174 VAL n 
1 175 LYS n 
1 176 PHE n 
1 177 ASN n 
1 178 ALA n 
1 179 LEU n 
1 180 GLU n 
1 181 LEU n 
1 182 ASP n 
1 183 ASP n 
1 184 SER n 
1 185 ASP n 
1 186 LEU n 
1 187 ALA n 
1 188 ILE n 
1 189 PHE n 
1 190 ILE n 
1 191 ALA n 
1 192 VAL n 
1 193 ILE n 
1 194 ILE n 
1 195 LEU n 
1 196 SER n 
1 197 GLY n 
1 198 ASP n 
1 199 ARG n 
1 200 PRO n 
1 201 GLY n 
1 202 LEU n 
1 203 LEU n 
1 204 ASN n 
1 205 VAL n 
1 206 LYS n 
1 207 PRO n 
1 208 ILE n 
1 209 GLU n 
1 210 ASP n 
1 211 ILE n 
1 212 GLN n 
1 213 ASP n 
1 214 ASN n 
1 215 LEU n 
1 216 LEU n 
1 217 GLN n 
1 218 ALA n 
1 219 LEU n 
1 220 GLU n 
1 221 LEU n 
1 222 GLN n 
1 223 LEU n 
1 224 LYS n 
1 225 LEU n 
1 226 ASN n 
1 227 HIS n 
1 228 PRO n 
1 229 GLU n 
1 230 SER n 
1 231 SER n 
1 232 GLN n 
1 233 LEU n 
1 234 PHE n 
1 235 ALA n 
1 236 LYS n 
1 237 LEU n 
1 238 LEU n 
1 239 GLN n 
1 240 LYS n 
1 241 MET n 
1 242 THR n 
1 243 ASP n 
1 244 LEU n 
1 245 ARG n 
1 246 GLN n 
1 247 ILE n 
1 248 VAL n 
1 249 THR n 
1 250 GLU n 
1 251 HIS n 
1 252 VAL n 
1 253 GLN n 
1 254 LEU n 
1 255 LEU n 
1 256 GLN n 
1 257 VAL n 
1 258 ILE n 
1 259 LYS n 
1 260 LYS n 
1 261 THR n 
1 262 GLU n 
1 263 THR n 
1 264 ASP n 
1 265 MET n 
1 266 SER n 
1 267 LEU n 
1 268 HIS n 
1 269 PRO n 
1 270 LEU n 
1 271 LEU n 
1 272 GLN n 
1 273 GLU n 
1 274 ILE n 
1 275 TYR n 
1 276 LYS n 
1 277 ASP n 
1 278 LEU n 
1 279 TYR n 
2 1   THR n 
2 2   ASN n 
2 3   MET n 
2 4   GLY n 
2 5   LEU n 
2 6   GLU n 
2 7   ALA n 
2 8   ILE n 
2 9   ILE n 
2 10  ARG n 
2 11  LYS n 
2 12  ALA n 
2 13  LEU n 
2 14  MET n 
2 15  GLY n 
2 16  LYS n 
2 17  TYR n 
2 18  ASP n 
2 19  GLN n 
2 20  TRP n 
2 21  GLU n 
2 22  GLU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   279 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 PPARG 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          plasmid 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       pET28a 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
_pdbx_entity_src_syn.entity_id              2 
_pdbx_entity_src_syn.pdbx_src_id            1 
_pdbx_entity_src_syn.pdbx_alt_source_flag   sample 
_pdbx_entity_src_syn.pdbx_beg_seq_num       1 
_pdbx_entity_src_syn.pdbx_end_seq_num       22 
_pdbx_entity_src_syn.organism_scientific    'Homo sapiens' 
_pdbx_entity_src_syn.organism_common_name   human 
_pdbx_entity_src_syn.ncbi_taxonomy_id       9606 
_pdbx_entity_src_syn.details                ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   199 ?   ?   ?   A . n 
A 1 2   SER 2   200 ?   ?   ?   A . n 
A 1 3   HIS 3   201 ?   ?   ?   A . n 
A 1 4   MET 4   202 202 MET MET A . n 
A 1 5   GLN 5   203 203 GLN GLN A . n 
A 1 6   LEU 6   204 204 LEU LEU A . n 
A 1 7   ASN 7   205 205 ASN ASN A . n 
A 1 8   PRO 8   206 206 PRO PRO A . n 
A 1 9   GLU 9   207 207 GLU GLU A . n 
A 1 10  SER 10  208 208 SER SER A . n 
A 1 11  ALA 11  209 209 ALA ALA A . n 
A 1 12  ASP 12  210 210 ASP ASP A . n 
A 1 13  LEU 13  211 211 LEU LEU A . n 
A 1 14  ARG 14  212 212 ARG ARG A . n 
A 1 15  ALA 15  213 213 ALA ALA A . n 
A 1 16  LEU 16  214 214 LEU LEU A . n 
A 1 17  ALA 17  215 215 ALA ALA A . n 
A 1 18  LYS 18  216 216 LYS LYS A . n 
A 1 19  HIS 19  217 217 HIS HIS A . n 
A 1 20  LEU 20  218 218 LEU LEU A . n 
A 1 21  TYR 21  219 219 TYR TYR A . n 
A 1 22  ASP 22  220 220 ASP ASP A . n 
A 1 23  SER 23  221 221 SER SER A . n 
A 1 24  TYR 24  222 222 TYR TYR A . n 
A 1 25  ILE 25  223 223 ILE ILE A . n 
A 1 26  LYS 26  224 224 LYS LYS A . n 
A 1 27  SER 27  225 225 SER SER A . n 
A 1 28  PHE 28  226 226 PHE PHE A . n 
A 1 29  PRO 29  227 227 PRO PRO A . n 
A 1 30  LEU 30  228 228 LEU LEU A . n 
A 1 31  THR 31  229 229 THR THR A . n 
A 1 32  LYS 32  230 230 LYS LYS A . n 
A 1 33  ALA 33  231 231 ALA ALA A . n 
A 1 34  LYS 34  232 232 LYS LYS A . n 
A 1 35  ALA 35  233 233 ALA ALA A . n 
A 1 36  ARG 36  234 234 ARG ARG A . n 
A 1 37  ALA 37  235 235 ALA ALA A . n 
A 1 38  ILE 38  236 236 ILE ILE A . n 
A 1 39  LEU 39  237 237 LEU LEU A . n 
A 1 40  THR 40  238 238 THR THR A . n 
A 1 41  GLY 41  239 239 GLY GLY A . n 
A 1 42  LYS 42  240 240 LYS LYS A . n 
A 1 43  THR 43  241 241 THR THR A . n 
A 1 44  THR 44  242 242 THR THR A . n 
A 1 45  ASP 45  243 243 ASP ASP A . n 
A 1 46  LYS 46  244 244 LYS LYS A . n 
A 1 47  SER 47  245 245 SER SER A . n 
A 1 48  PRO 48  246 246 PRO PRO A . n 
A 1 49  PHE 49  247 247 PHE PHE A . n 
A 1 50  VAL 50  248 248 VAL VAL A . n 
A 1 51  ILE 51  249 249 ILE ILE A . n 
A 1 52  TYR 52  250 250 TYR TYR A . n 
A 1 53  ASP 53  251 251 ASP ASP A . n 
A 1 54  MET 54  252 252 MET MET A . n 
A 1 55  ASN 55  253 253 ASN ASN A . n 
A 1 56  SER 56  254 254 SER SER A . n 
A 1 57  LEU 57  255 255 LEU LEU A . n 
A 1 58  MET 58  256 256 MET MET A . n 
A 1 59  MET 59  257 257 MET MET A . n 
A 1 60  GLY 60  258 258 GLY GLY A . n 
A 1 61  GLU 61  259 259 GLU GLU A . n 
A 1 62  ASP 62  260 ?   ?   ?   A . n 
A 1 63  LYS 63  261 ?   ?   ?   A . n 
A 1 64  ILE 64  262 ?   ?   ?   A . n 
A 1 65  LYS 65  263 ?   ?   ?   A . n 
A 1 66  PHE 66  264 ?   ?   ?   A . n 
A 1 67  LYS 67  265 ?   ?   ?   A . n 
A 1 68  HIS 68  266 ?   ?   ?   A . n 
A 1 69  ILE 69  267 ?   ?   ?   A . n 
A 1 70  THR 70  268 ?   ?   ?   A . n 
A 1 71  PRO 71  269 ?   ?   ?   A . n 
A 1 72  LEU 72  270 ?   ?   ?   A . n 
A 1 73  GLN 73  271 ?   ?   ?   A . n 
A 1 74  GLU 74  272 ?   ?   ?   A . n 
A 1 75  GLN 75  273 ?   ?   ?   A . n 
A 1 76  SER 76  274 ?   ?   ?   A . n 
A 1 77  LYS 77  275 ?   ?   ?   A . n 
A 1 78  GLU 78  276 ?   ?   ?   A . n 
A 1 79  VAL 79  277 ?   ?   ?   A . n 
A 1 80  ALA 80  278 ?   ?   ?   A . n 
A 1 81  ILE 81  279 ?   ?   ?   A . n 
A 1 82  ARG 82  280 ?   ?   ?   A . n 
A 1 83  ILE 83  281 ?   ?   ?   A . n 
A 1 84  PHE 84  282 ?   ?   ?   A . n 
A 1 85  GLN 85  283 ?   ?   ?   A . n 
A 1 86  GLY 86  284 ?   ?   ?   A . n 
A 1 87  CYS 87  285 ?   ?   ?   A . n 
A 1 88  GLN 88  286 ?   ?   ?   A . n 
A 1 89  PHE 89  287 ?   ?   ?   A . n 
A 1 90  ARG 90  288 ?   ?   ?   A . n 
A 1 91  SER 91  289 289 SER SER A . n 
A 1 92  VAL 92  290 290 VAL VAL A . n 
A 1 93  GLU 93  291 291 GLU GLU A . n 
A 1 94  ALA 94  292 292 ALA ALA A . n 
A 1 95  VAL 95  293 293 VAL VAL A . n 
A 1 96  GLN 96  294 294 GLN GLN A . n 
A 1 97  GLU 97  295 295 GLU GLU A . n 
A 1 98  ILE 98  296 296 ILE ILE A . n 
A 1 99  THR 99  297 297 THR THR A . n 
A 1 100 GLU 100 298 298 GLU GLU A . n 
A 1 101 TYR 101 299 299 TYR TYR A . n 
A 1 102 ALA 102 300 300 ALA ALA A . n 
A 1 103 LYS 103 301 301 LYS LYS A . n 
A 1 104 SER 104 302 302 SER SER A . n 
A 1 105 ILE 105 303 303 ILE ILE A . n 
A 1 106 PRO 106 304 304 PRO PRO A . n 
A 1 107 GLY 107 305 305 GLY GLY A . n 
A 1 108 PHE 108 306 306 PHE PHE A . n 
A 1 109 VAL 109 307 307 VAL VAL A . n 
A 1 110 ASN 110 308 308 ASN ASN A . n 
A 1 111 LEU 111 309 309 LEU LEU A . n 
A 1 112 ASP 112 310 310 ASP ASP A . n 
A 1 113 LEU 113 311 311 LEU LEU A . n 
A 1 114 ASN 114 312 312 ASN ASN A . n 
A 1 115 ASP 115 313 313 ASP ASP A . n 
A 1 116 GLN 116 314 314 GLN GLN A . n 
A 1 117 VAL 117 315 315 VAL VAL A . n 
A 1 118 THR 118 316 316 THR THR A . n 
A 1 119 LEU 119 317 317 LEU LEU A . n 
A 1 120 LEU 120 318 318 LEU LEU A . n 
A 1 121 LYS 121 319 319 LYS LYS A . n 
A 1 122 TYR 122 320 320 TYR TYR A . n 
A 1 123 GLY 123 321 321 GLY GLY A . n 
A 1 124 VAL 124 322 322 VAL VAL A . n 
A 1 125 HIS 125 323 323 HIS HIS A . n 
A 1 126 GLU 126 324 324 GLU GLU A . n 
A 1 127 ILE 127 325 325 ILE ILE A . n 
A 1 128 ILE 128 326 326 ILE ILE A . n 
A 1 129 TYR 129 327 327 TYR TYR A . n 
A 1 130 THR 130 328 328 THR THR A . n 
A 1 131 MET 131 329 329 MET MET A . n 
A 1 132 LEU 132 330 330 LEU LEU A . n 
A 1 133 ALA 133 331 331 ALA ALA A . n 
A 1 134 SER 134 332 332 SER SER A . n 
A 1 135 LEU 135 333 333 LEU LEU A . n 
A 1 136 MET 136 334 334 MET MET A . n 
A 1 137 ASN 137 335 335 ASN ASN A . n 
A 1 138 LYS 138 336 336 LYS LYS A . n 
A 1 139 ASP 139 337 337 ASP ASP A . n 
A 1 140 GLY 140 338 338 GLY GLY A . n 
A 1 141 VAL 141 339 339 VAL VAL A . n 
A 1 142 LEU 142 340 340 LEU LEU A . n 
A 1 143 ILE 143 341 341 ILE ILE A . n 
A 1 144 SER 144 342 342 SER SER A . n 
A 1 145 GLU 145 343 343 GLU GLU A . n 
A 1 146 GLY 146 344 344 GLY GLY A . n 
A 1 147 GLN 147 345 345 GLN GLN A . n 
A 1 148 GLY 148 346 346 GLY GLY A . n 
A 1 149 PHE 149 347 347 PHE PHE A . n 
A 1 150 MET 150 348 348 MET MET A . n 
A 1 151 THR 151 349 349 THR THR A . n 
A 1 152 ARG 152 350 350 ARG ARG A . n 
A 1 153 GLU 153 351 351 GLU GLU A . n 
A 1 154 PHE 154 352 352 PHE PHE A . n 
A 1 155 LEU 155 353 353 LEU LEU A . n 
A 1 156 LYS 156 354 354 LYS LYS A . n 
A 1 157 SER 157 355 355 SER SER A . n 
A 1 158 LEU 158 356 356 LEU LEU A . n 
A 1 159 ARG 159 357 357 ARG ARG A . n 
A 1 160 LYS 160 358 358 LYS LYS A . n 
A 1 161 PRO 161 359 359 PRO PRO A . n 
A 1 162 PHE 162 360 360 PHE PHE A . n 
A 1 163 GLY 163 361 361 GLY GLY A . n 
A 1 164 ASP 164 362 362 ASP ASP A . n 
A 1 165 PHE 165 363 363 PHE PHE A . n 
A 1 166 MET 166 364 364 MET MET A . n 
A 1 167 GLU 167 365 365 GLU GLU A . n 
A 1 168 PRO 168 366 366 PRO PRO A . n 
A 1 169 LYS 169 367 367 LYS LYS A . n 
A 1 170 PHE 170 368 368 PHE PHE A . n 
A 1 171 GLU 171 369 369 GLU GLU A . n 
A 1 172 PHE 172 370 370 PHE PHE A . n 
A 1 173 ALA 173 371 371 ALA ALA A . n 
A 1 174 VAL 174 372 372 VAL VAL A . n 
A 1 175 LYS 175 373 373 LYS LYS A . n 
A 1 176 PHE 176 374 374 PHE PHE A . n 
A 1 177 ASN 177 375 375 ASN ASN A . n 
A 1 178 ALA 178 376 376 ALA ALA A . n 
A 1 179 LEU 179 377 377 LEU LEU A . n 
A 1 180 GLU 180 378 378 GLU GLU A . n 
A 1 181 LEU 181 379 379 LEU LEU A . n 
A 1 182 ASP 182 380 380 ASP ASP A . n 
A 1 183 ASP 183 381 381 ASP ASP A . n 
A 1 184 SER 184 382 382 SER SER A . n 
A 1 185 ASP 185 383 383 ASP ASP A . n 
A 1 186 LEU 186 384 384 LEU LEU A . n 
A 1 187 ALA 187 385 385 ALA ALA A . n 
A 1 188 ILE 188 386 386 ILE ILE A . n 
A 1 189 PHE 189 387 387 PHE PHE A . n 
A 1 190 ILE 190 388 388 ILE ILE A . n 
A 1 191 ALA 191 389 389 ALA ALA A . n 
A 1 192 VAL 192 390 390 VAL VAL A . n 
A 1 193 ILE 193 391 391 ILE ILE A . n 
A 1 194 ILE 194 392 392 ILE ILE A . n 
A 1 195 LEU 195 393 393 LEU LEU A . n 
A 1 196 SER 196 394 394 SER SER A . n 
A 1 197 GLY 197 395 395 GLY GLY A . n 
A 1 198 ASP 198 396 396 ASP ASP A . n 
A 1 199 ARG 199 397 397 ARG ARG A . n 
A 1 200 PRO 200 398 398 PRO PRO A . n 
A 1 201 GLY 201 399 399 GLY GLY A . n 
A 1 202 LEU 202 400 400 LEU LEU A . n 
A 1 203 LEU 203 401 401 LEU LEU A . n 
A 1 204 ASN 204 402 402 ASN ASN A . n 
A 1 205 VAL 205 403 403 VAL VAL A . n 
A 1 206 LYS 206 404 404 LYS LYS A . n 
A 1 207 PRO 207 405 405 PRO PRO A . n 
A 1 208 ILE 208 406 406 ILE ILE A . n 
A 1 209 GLU 209 407 407 GLU GLU A . n 
A 1 210 ASP 210 408 408 ASP ASP A . n 
A 1 211 ILE 211 409 409 ILE ILE A . n 
A 1 212 GLN 212 410 410 GLN GLN A . n 
A 1 213 ASP 213 411 411 ASP ASP A . n 
A 1 214 ASN 214 412 412 ASN ASN A . n 
A 1 215 LEU 215 413 413 LEU LEU A . n 
A 1 216 LEU 216 414 414 LEU LEU A . n 
A 1 217 GLN 217 415 415 GLN GLN A . n 
A 1 218 ALA 218 416 416 ALA ALA A . n 
A 1 219 LEU 219 417 417 LEU LEU A . n 
A 1 220 GLU 220 418 418 GLU GLU A . n 
A 1 221 LEU 221 419 419 LEU LEU A . n 
A 1 222 GLN 222 420 420 GLN GLN A . n 
A 1 223 LEU 223 421 421 LEU LEU A . n 
A 1 224 LYS 224 422 422 LYS LYS A . n 
A 1 225 LEU 225 423 423 LEU LEU A . n 
A 1 226 ASN 226 424 424 ASN ASN A . n 
A 1 227 HIS 227 425 425 HIS HIS A . n 
A 1 228 PRO 228 426 426 PRO PRO A . n 
A 1 229 GLU 229 427 427 GLU GLU A . n 
A 1 230 SER 230 428 428 SER SER A . n 
A 1 231 SER 231 429 429 SER SER A . n 
A 1 232 GLN 232 430 430 GLN GLN A . n 
A 1 233 LEU 233 431 431 LEU LEU A . n 
A 1 234 PHE 234 432 432 PHE PHE A . n 
A 1 235 ALA 235 433 433 ALA ALA A . n 
A 1 236 LYS 236 434 434 LYS LYS A . n 
A 1 237 LEU 237 435 435 LEU LEU A . n 
A 1 238 LEU 238 436 436 LEU LEU A . n 
A 1 239 GLN 239 437 437 GLN GLN A . n 
A 1 240 LYS 240 438 438 LYS LYS A . n 
A 1 241 MET 241 439 439 MET MET A . n 
A 1 242 THR 242 440 440 THR THR A . n 
A 1 243 ASP 243 441 441 ASP ASP A . n 
A 1 244 LEU 244 442 442 LEU LEU A . n 
A 1 245 ARG 245 443 443 ARG ARG A . n 
A 1 246 GLN 246 444 444 GLN GLN A . n 
A 1 247 ILE 247 445 445 ILE ILE A . n 
A 1 248 VAL 248 446 446 VAL VAL A . n 
A 1 249 THR 249 447 447 THR THR A . n 
A 1 250 GLU 250 448 448 GLU GLU A . n 
A 1 251 HIS 251 449 449 HIS HIS A . n 
A 1 252 VAL 252 450 450 VAL VAL A . n 
A 1 253 GLN 253 451 451 GLN GLN A . n 
A 1 254 LEU 254 452 452 LEU LEU A . n 
A 1 255 LEU 255 453 453 LEU LEU A . n 
A 1 256 GLN 256 454 454 GLN GLN A . n 
A 1 257 VAL 257 455 455 VAL VAL A . n 
A 1 258 ILE 258 456 ?   ?   ?   A . n 
A 1 259 LYS 259 457 ?   ?   ?   A . n 
A 1 260 LYS 260 458 ?   ?   ?   A . n 
A 1 261 THR 261 459 ?   ?   ?   A . n 
A 1 262 GLU 262 460 ?   ?   ?   A . n 
A 1 263 THR 263 461 ?   ?   ?   A . n 
A 1 264 ASP 264 462 ?   ?   ?   A . n 
A 1 265 MET 265 463 ?   ?   ?   A . n 
A 1 266 SER 266 464 ?   ?   ?   A . n 
A 1 267 LEU 267 465 ?   ?   ?   A . n 
A 1 268 HIS 268 466 ?   ?   ?   A . n 
A 1 269 PRO 269 467 ?   ?   ?   A . n 
A 1 270 LEU 270 468 ?   ?   ?   A . n 
A 1 271 LEU 271 469 ?   ?   ?   A . n 
A 1 272 GLN 272 470 ?   ?   ?   A . n 
A 1 273 GLU 273 471 ?   ?   ?   A . n 
A 1 274 ILE 274 472 ?   ?   ?   A . n 
A 1 275 TYR 275 473 ?   ?   ?   A . n 
A 1 276 LYS 276 474 ?   ?   ?   A . n 
A 1 277 ASP 277 475 ?   ?   ?   A . n 
A 1 278 LEU 278 476 ?   ?   ?   A . n 
A 1 279 TYR 279 477 ?   ?   ?   A . n 
B 2 1   THR 1   137 ?   ?   ?   B . n 
B 2 2   ASN 2   138 ?   ?   ?   B . n 
B 2 3   MET 3   139 ?   ?   ?   B . n 
B 2 4   GLY 4   140 ?   ?   ?   B . n 
B 2 5   LEU 5   141 141 LEU LEU B . n 
B 2 6   GLU 6   142 142 GLU GLU B . n 
B 2 7   ALA 7   143 143 ALA ALA B . n 
B 2 8   ILE 8   144 144 ILE ILE B . n 
B 2 9   ILE 9   145 145 ILE ILE B . n 
B 2 10  ARG 10  146 146 ARG ARG B . n 
B 2 11  LYS 11  147 147 LYS LYS B . n 
B 2 12  ALA 12  148 148 ALA ALA B . n 
B 2 13  LEU 13  149 149 LEU LEU B . n 
B 2 14  MET 14  150 ?   ?   ?   B . n 
B 2 15  GLY 15  151 ?   ?   ?   B . n 
B 2 16  LYS 16  152 ?   ?   ?   B . n 
B 2 17  TYR 17  153 ?   ?   ?   B . n 
B 2 18  ASP 18  154 ?   ?   ?   B . n 
B 2 19  GLN 19  155 ?   ?   ?   B . n 
B 2 20  TRP 20  156 ?   ?   ?   B . n 
B 2 21  GLU 21  157 ?   ?   ?   B . n 
B 2 22  GLU 22  158 ?   ?   ?   B . n 
C 1 1   GLY 1   199 ?   ?   ?   C . n 
C 1 2   SER 2   200 ?   ?   ?   C . n 
C 1 3   HIS 3   201 ?   ?   ?   C . n 
C 1 4   MET 4   202 ?   ?   ?   C . n 
C 1 5   GLN 5   203 ?   ?   ?   C . n 
C 1 6   LEU 6   204 ?   ?   ?   C . n 
C 1 7   ASN 7   205 ?   ?   ?   C . n 
C 1 8   PRO 8   206 206 PRO PRO C . n 
C 1 9   GLU 9   207 207 GLU GLU C . n 
C 1 10  SER 10  208 208 SER SER C . n 
C 1 11  ALA 11  209 209 ALA ALA C . n 
C 1 12  ASP 12  210 210 ASP ASP C . n 
C 1 13  LEU 13  211 211 LEU LEU C . n 
C 1 14  ARG 14  212 212 ARG ARG C . n 
C 1 15  ALA 15  213 213 ALA ALA C . n 
C 1 16  LEU 16  214 214 LEU LEU C . n 
C 1 17  ALA 17  215 215 ALA ALA C . n 
C 1 18  LYS 18  216 216 LYS LYS C . n 
C 1 19  HIS 19  217 217 HIS HIS C . n 
C 1 20  LEU 20  218 218 LEU LEU C . n 
C 1 21  TYR 21  219 219 TYR TYR C . n 
C 1 22  ASP 22  220 220 ASP ASP C . n 
C 1 23  SER 23  221 221 SER SER C . n 
C 1 24  TYR 24  222 222 TYR TYR C . n 
C 1 25  ILE 25  223 223 ILE ILE C . n 
C 1 26  LYS 26  224 224 LYS LYS C . n 
C 1 27  SER 27  225 225 SER SER C . n 
C 1 28  PHE 28  226 226 PHE PHE C . n 
C 1 29  PRO 29  227 227 PRO PRO C . n 
C 1 30  LEU 30  228 228 LEU LEU C . n 
C 1 31  THR 31  229 229 THR THR C . n 
C 1 32  LYS 32  230 230 LYS LYS C . n 
C 1 33  ALA 33  231 231 ALA ALA C . n 
C 1 34  LYS 34  232 232 LYS LYS C . n 
C 1 35  ALA 35  233 233 ALA ALA C . n 
C 1 36  ARG 36  234 234 ARG ARG C . n 
C 1 37  ALA 37  235 235 ALA ALA C . n 
C 1 38  ILE 38  236 236 ILE ILE C . n 
C 1 39  LEU 39  237 237 LEU LEU C . n 
C 1 40  THR 40  238 238 THR THR C . n 
C 1 41  GLY 41  239 239 GLY GLY C . n 
C 1 42  LYS 42  240 240 LYS LYS C . n 
C 1 43  THR 43  241 241 THR THR C . n 
C 1 44  THR 44  242 242 THR THR C . n 
C 1 45  ASP 45  243 243 ASP ASP C . n 
C 1 46  LYS 46  244 244 LYS LYS C . n 
C 1 47  SER 47  245 245 SER SER C . n 
C 1 48  PRO 48  246 246 PRO PRO C . n 
C 1 49  PHE 49  247 247 PHE PHE C . n 
C 1 50  VAL 50  248 248 VAL VAL C . n 
C 1 51  ILE 51  249 249 ILE ILE C . n 
C 1 52  TYR 52  250 250 TYR TYR C . n 
C 1 53  ASP 53  251 251 ASP ASP C . n 
C 1 54  MET 54  252 252 MET MET C . n 
C 1 55  ASN 55  253 253 ASN ASN C . n 
C 1 56  SER 56  254 254 SER SER C . n 
C 1 57  LEU 57  255 255 LEU LEU C . n 
C 1 58  MET 58  256 256 MET MET C . n 
C 1 59  MET 59  257 257 MET MET C . n 
C 1 60  GLY 60  258 258 GLY GLY C . n 
C 1 61  GLU 61  259 259 GLU GLU C . n 
C 1 62  ASP 62  260 260 ASP ASP C . n 
C 1 63  LYS 63  261 261 LYS LYS C . n 
C 1 64  ILE 64  262 262 ILE ILE C . n 
C 1 65  LYS 65  263 263 LYS LYS C . n 
C 1 66  PHE 66  264 264 PHE PHE C . n 
C 1 67  LYS 67  265 265 LYS LYS C . n 
C 1 68  HIS 68  266 266 HIS HIS C . n 
C 1 69  ILE 69  267 ?   ?   ?   C . n 
C 1 70  THR 70  268 ?   ?   ?   C . n 
C 1 71  PRO 71  269 ?   ?   ?   C . n 
C 1 72  LEU 72  270 ?   ?   ?   C . n 
C 1 73  GLN 73  271 ?   ?   ?   C . n 
C 1 74  GLU 74  272 ?   ?   ?   C . n 
C 1 75  GLN 75  273 ?   ?   ?   C . n 
C 1 76  SER 76  274 ?   ?   ?   C . n 
C 1 77  LYS 77  275 275 LYS LYS C . n 
C 1 78  GLU 78  276 276 GLU GLU C . n 
C 1 79  VAL 79  277 277 VAL VAL C . n 
C 1 80  ALA 80  278 278 ALA ALA C . n 
C 1 81  ILE 81  279 279 ILE ILE C . n 
C 1 82  ARG 82  280 280 ARG ARG C . n 
C 1 83  ILE 83  281 281 ILE ILE C . n 
C 1 84  PHE 84  282 282 PHE PHE C . n 
C 1 85  GLN 85  283 283 GLN GLN C . n 
C 1 86  GLY 86  284 284 GLY GLY C . n 
C 1 87  CYS 87  285 285 CYS CYS C . n 
C 1 88  GLN 88  286 286 GLN GLN C . n 
C 1 89  PHE 89  287 287 PHE PHE C . n 
C 1 90  ARG 90  288 288 ARG ARG C . n 
C 1 91  SER 91  289 289 SER SER C . n 
C 1 92  VAL 92  290 290 VAL VAL C . n 
C 1 93  GLU 93  291 291 GLU GLU C . n 
C 1 94  ALA 94  292 292 ALA ALA C . n 
C 1 95  VAL 95  293 293 VAL VAL C . n 
C 1 96  GLN 96  294 294 GLN GLN C . n 
C 1 97  GLU 97  295 295 GLU GLU C . n 
C 1 98  ILE 98  296 296 ILE ILE C . n 
C 1 99  THR 99  297 297 THR THR C . n 
C 1 100 GLU 100 298 298 GLU GLU C . n 
C 1 101 TYR 101 299 299 TYR TYR C . n 
C 1 102 ALA 102 300 300 ALA ALA C . n 
C 1 103 LYS 103 301 301 LYS LYS C . n 
C 1 104 SER 104 302 302 SER SER C . n 
C 1 105 ILE 105 303 303 ILE ILE C . n 
C 1 106 PRO 106 304 304 PRO PRO C . n 
C 1 107 GLY 107 305 305 GLY GLY C . n 
C 1 108 PHE 108 306 306 PHE PHE C . n 
C 1 109 VAL 109 307 307 VAL VAL C . n 
C 1 110 ASN 110 308 308 ASN ASN C . n 
C 1 111 LEU 111 309 309 LEU LEU C . n 
C 1 112 ASP 112 310 310 ASP ASP C . n 
C 1 113 LEU 113 311 311 LEU LEU C . n 
C 1 114 ASN 114 312 312 ASN ASN C . n 
C 1 115 ASP 115 313 313 ASP ASP C . n 
C 1 116 GLN 116 314 314 GLN GLN C . n 
C 1 117 VAL 117 315 315 VAL VAL C . n 
C 1 118 THR 118 316 316 THR THR C . n 
C 1 119 LEU 119 317 317 LEU LEU C . n 
C 1 120 LEU 120 318 318 LEU LEU C . n 
C 1 121 LYS 121 319 319 LYS LYS C . n 
C 1 122 TYR 122 320 320 TYR TYR C . n 
C 1 123 GLY 123 321 321 GLY GLY C . n 
C 1 124 VAL 124 322 322 VAL VAL C . n 
C 1 125 HIS 125 323 323 HIS HIS C . n 
C 1 126 GLU 126 324 324 GLU GLU C . n 
C 1 127 ILE 127 325 325 ILE ILE C . n 
C 1 128 ILE 128 326 326 ILE ILE C . n 
C 1 129 TYR 129 327 327 TYR TYR C . n 
C 1 130 THR 130 328 328 THR THR C . n 
C 1 131 MET 131 329 329 MET MET C . n 
C 1 132 LEU 132 330 330 LEU LEU C . n 
C 1 133 ALA 133 331 331 ALA ALA C . n 
C 1 134 SER 134 332 332 SER SER C . n 
C 1 135 LEU 135 333 333 LEU LEU C . n 
C 1 136 MET 136 334 334 MET MET C . n 
C 1 137 ASN 137 335 335 ASN ASN C . n 
C 1 138 LYS 138 336 336 LYS LYS C . n 
C 1 139 ASP 139 337 337 ASP ASP C . n 
C 1 140 GLY 140 338 338 GLY GLY C . n 
C 1 141 VAL 141 339 339 VAL VAL C . n 
C 1 142 LEU 142 340 340 LEU LEU C . n 
C 1 143 ILE 143 341 341 ILE ILE C . n 
C 1 144 SER 144 342 342 SER SER C . n 
C 1 145 GLU 145 343 343 GLU GLU C . n 
C 1 146 GLY 146 344 344 GLY GLY C . n 
C 1 147 GLN 147 345 345 GLN GLN C . n 
C 1 148 GLY 148 346 346 GLY GLY C . n 
C 1 149 PHE 149 347 347 PHE PHE C . n 
C 1 150 MET 150 348 348 MET MET C . n 
C 1 151 THR 151 349 349 THR THR C . n 
C 1 152 ARG 152 350 350 ARG ARG C . n 
C 1 153 GLU 153 351 351 GLU GLU C . n 
C 1 154 PHE 154 352 352 PHE PHE C . n 
C 1 155 LEU 155 353 353 LEU LEU C . n 
C 1 156 LYS 156 354 354 LYS LYS C . n 
C 1 157 SER 157 355 355 SER SER C . n 
C 1 158 LEU 158 356 356 LEU LEU C . n 
C 1 159 ARG 159 357 357 ARG ARG C . n 
C 1 160 LYS 160 358 358 LYS LYS C . n 
C 1 161 PRO 161 359 359 PRO PRO C . n 
C 1 162 PHE 162 360 360 PHE PHE C . n 
C 1 163 GLY 163 361 361 GLY GLY C . n 
C 1 164 ASP 164 362 362 ASP ASP C . n 
C 1 165 PHE 165 363 363 PHE PHE C . n 
C 1 166 MET 166 364 364 MET MET C . n 
C 1 167 GLU 167 365 365 GLU GLU C . n 
C 1 168 PRO 168 366 366 PRO PRO C . n 
C 1 169 LYS 169 367 367 LYS LYS C . n 
C 1 170 PHE 170 368 368 PHE PHE C . n 
C 1 171 GLU 171 369 369 GLU GLU C . n 
C 1 172 PHE 172 370 370 PHE PHE C . n 
C 1 173 ALA 173 371 371 ALA ALA C . n 
C 1 174 VAL 174 372 372 VAL VAL C . n 
C 1 175 LYS 175 373 373 LYS LYS C . n 
C 1 176 PHE 176 374 374 PHE PHE C . n 
C 1 177 ASN 177 375 375 ASN ASN C . n 
C 1 178 ALA 178 376 376 ALA ALA C . n 
C 1 179 LEU 179 377 377 LEU LEU C . n 
C 1 180 GLU 180 378 378 GLU GLU C . n 
C 1 181 LEU 181 379 379 LEU LEU C . n 
C 1 182 ASP 182 380 380 ASP ASP C . n 
C 1 183 ASP 183 381 381 ASP ASP C . n 
C 1 184 SER 184 382 382 SER SER C . n 
C 1 185 ASP 185 383 383 ASP ASP C . n 
C 1 186 LEU 186 384 384 LEU LEU C . n 
C 1 187 ALA 187 385 385 ALA ALA C . n 
C 1 188 ILE 188 386 386 ILE ILE C . n 
C 1 189 PHE 189 387 387 PHE PHE C . n 
C 1 190 ILE 190 388 388 ILE ILE C . n 
C 1 191 ALA 191 389 389 ALA ALA C . n 
C 1 192 VAL 192 390 390 VAL VAL C . n 
C 1 193 ILE 193 391 391 ILE ILE C . n 
C 1 194 ILE 194 392 392 ILE ILE C . n 
C 1 195 LEU 195 393 393 LEU LEU C . n 
C 1 196 SER 196 394 394 SER SER C . n 
C 1 197 GLY 197 395 395 GLY GLY C . n 
C 1 198 ASP 198 396 396 ASP ASP C . n 
C 1 199 ARG 199 397 397 ARG ARG C . n 
C 1 200 PRO 200 398 398 PRO PRO C . n 
C 1 201 GLY 201 399 399 GLY GLY C . n 
C 1 202 LEU 202 400 400 LEU LEU C . n 
C 1 203 LEU 203 401 401 LEU LEU C . n 
C 1 204 ASN 204 402 402 ASN ASN C . n 
C 1 205 VAL 205 403 403 VAL VAL C . n 
C 1 206 LYS 206 404 404 LYS LYS C . n 
C 1 207 PRO 207 405 405 PRO PRO C . n 
C 1 208 ILE 208 406 406 ILE ILE C . n 
C 1 209 GLU 209 407 407 GLU GLU C . n 
C 1 210 ASP 210 408 408 ASP ASP C . n 
C 1 211 ILE 211 409 409 ILE ILE C . n 
C 1 212 GLN 212 410 410 GLN GLN C . n 
C 1 213 ASP 213 411 411 ASP ASP C . n 
C 1 214 ASN 214 412 412 ASN ASN C . n 
C 1 215 LEU 215 413 413 LEU LEU C . n 
C 1 216 LEU 216 414 414 LEU LEU C . n 
C 1 217 GLN 217 415 415 GLN GLN C . n 
C 1 218 ALA 218 416 416 ALA ALA C . n 
C 1 219 LEU 219 417 417 LEU LEU C . n 
C 1 220 GLU 220 418 418 GLU GLU C . n 
C 1 221 LEU 221 419 419 LEU LEU C . n 
C 1 222 GLN 222 420 420 GLN GLN C . n 
C 1 223 LEU 223 421 421 LEU LEU C . n 
C 1 224 LYS 224 422 422 LYS LYS C . n 
C 1 225 LEU 225 423 423 LEU LEU C . n 
C 1 226 ASN 226 424 424 ASN ASN C . n 
C 1 227 HIS 227 425 425 HIS HIS C . n 
C 1 228 PRO 228 426 426 PRO PRO C . n 
C 1 229 GLU 229 427 427 GLU GLU C . n 
C 1 230 SER 230 428 428 SER SER C . n 
C 1 231 SER 231 429 429 SER SER C . n 
C 1 232 GLN 232 430 430 GLN GLN C . n 
C 1 233 LEU 233 431 431 LEU LEU C . n 
C 1 234 PHE 234 432 432 PHE PHE C . n 
C 1 235 ALA 235 433 433 ALA ALA C . n 
C 1 236 LYS 236 434 434 LYS LYS C . n 
C 1 237 LEU 237 435 435 LEU LEU C . n 
C 1 238 LEU 238 436 436 LEU LEU C . n 
C 1 239 GLN 239 437 437 GLN GLN C . n 
C 1 240 LYS 240 438 438 LYS LYS C . n 
C 1 241 MET 241 439 439 MET MET C . n 
C 1 242 THR 242 440 440 THR THR C . n 
C 1 243 ASP 243 441 441 ASP ASP C . n 
C 1 244 LEU 244 442 442 LEU LEU C . n 
C 1 245 ARG 245 443 443 ARG ARG C . n 
C 1 246 GLN 246 444 444 GLN GLN C . n 
C 1 247 ILE 247 445 445 ILE ILE C . n 
C 1 248 VAL 248 446 446 VAL VAL C . n 
C 1 249 THR 249 447 447 THR THR C . n 
C 1 250 GLU 250 448 448 GLU GLU C . n 
C 1 251 HIS 251 449 449 HIS HIS C . n 
C 1 252 VAL 252 450 450 VAL VAL C . n 
C 1 253 GLN 253 451 451 GLN GLN C . n 
C 1 254 LEU 254 452 452 LEU LEU C . n 
C 1 255 LEU 255 453 453 LEU LEU C . n 
C 1 256 GLN 256 454 454 GLN GLN C . n 
C 1 257 VAL 257 455 455 VAL VAL C . n 
C 1 258 ILE 258 456 456 ILE ILE C . n 
C 1 259 LYS 259 457 457 LYS LYS C . n 
C 1 260 LYS 260 458 458 LYS LYS C . n 
C 1 261 THR 261 459 459 THR THR C . n 
C 1 262 GLU 262 460 460 GLU GLU C . n 
C 1 263 THR 263 461 ?   ?   ?   C . n 
C 1 264 ASP 264 462 ?   ?   ?   C . n 
C 1 265 MET 265 463 ?   ?   ?   C . n 
C 1 266 SER 266 464 ?   ?   ?   C . n 
C 1 267 LEU 267 465 ?   ?   ?   C . n 
C 1 268 HIS 268 466 ?   ?   ?   C . n 
C 1 269 PRO 269 467 ?   ?   ?   C . n 
C 1 270 LEU 270 468 ?   ?   ?   C . n 
C 1 271 LEU 271 469 ?   ?   ?   C . n 
C 1 272 GLN 272 470 ?   ?   ?   C . n 
C 1 273 GLU 273 471 ?   ?   ?   C . n 
C 1 274 ILE 274 472 ?   ?   ?   C . n 
C 1 275 TYR 275 473 ?   ?   ?   C . n 
C 1 276 LYS 276 474 ?   ?   ?   C . n 
C 1 277 ASP 277 475 ?   ?   ?   C . n 
C 1 278 LEU 278 476 ?   ?   ?   C . n 
C 1 279 TYR 279 477 ?   ?   ?   C . n 
D 2 1   THR 1   137 ?   ?   ?   D . n 
D 2 2   ASN 2   138 ?   ?   ?   D . n 
D 2 3   MET 3   139 ?   ?   ?   D . n 
D 2 4   GLY 4   140 140 GLY GLY D . n 
D 2 5   LEU 5   141 141 LEU LEU D . n 
D 2 6   GLU 6   142 142 GLU GLU D . n 
D 2 7   ALA 7   143 143 ALA ALA D . n 
D 2 8   ILE 8   144 144 ILE ILE D . n 
D 2 9   ILE 9   145 145 ILE ILE D . n 
D 2 10  ARG 10  146 146 ARG ARG D . n 
D 2 11  LYS 11  147 147 LYS LYS D . n 
D 2 12  ALA 12  148 148 ALA ALA D . n 
D 2 13  LEU 13  149 149 LEU LEU D . n 
D 2 14  MET 14  150 ?   ?   ?   D . n 
D 2 15  GLY 15  151 ?   ?   ?   D . n 
D 2 16  LYS 16  152 ?   ?   ?   D . n 
D 2 17  TYR 17  153 ?   ?   ?   D . n 
D 2 18  ASP 18  154 ?   ?   ?   D . n 
D 2 19  GLN 19  155 ?   ?   ?   D . n 
D 2 20  TRP 20  156 ?   ?   ?   D . n 
D 2 21  GLU 21  157 ?   ?   ?   D . n 
D 2 22  GLU 22  158 ?   ?   ?   D . n 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A LYS 240 ? CG  ? A LYS 42  CG  
2  1 Y 1 A LYS 240 ? CD  ? A LYS 42  CD  
3  1 Y 1 A LYS 240 ? CE  ? A LYS 42  CE  
4  1 Y 1 A LYS 240 ? NZ  ? A LYS 42  NZ  
5  1 Y 1 C GLN 283 ? CG  ? C GLN 85  CG  
6  1 Y 1 C GLN 283 ? CD  ? C GLN 85  CD  
7  1 Y 1 C GLN 283 ? OE1 ? C GLN 85  OE1 
8  1 Y 1 C GLN 283 ? NE2 ? C GLN 85  NE2 
9  1 Y 1 C GLN 286 ? CG  ? C GLN 88  CG  
10 1 Y 1 C GLN 286 ? CD  ? C GLN 88  CD  
11 1 Y 1 C GLN 286 ? OE1 ? C GLN 88  OE1 
12 1 Y 1 C GLN 286 ? NE2 ? C GLN 88  NE2 
13 1 Y 1 C PHE 363 ? CG  ? C PHE 165 CG  
14 1 Y 1 C PHE 363 ? CD1 ? C PHE 165 CD1 
15 1 Y 1 C PHE 363 ? CD2 ? C PHE 165 CD2 
16 1 Y 1 C PHE 363 ? CE1 ? C PHE 165 CE1 
17 1 Y 1 C PHE 363 ? CE2 ? C PHE 165 CE2 
18 1 Y 1 C PHE 363 ? CZ  ? C PHE 165 CZ  
19 1 Y 1 C LYS 458 ? CG  ? C LYS 260 CG  
20 1 Y 1 C LYS 458 ? CD  ? C LYS 260 CD  
21 1 Y 1 C LYS 458 ? CE  ? C LYS 260 CE  
22 1 Y 1 C LYS 458 ? NZ  ? C LYS 260 NZ  
23 1 Y 1 D LYS 147 ? CG  ? D LYS 11  CG  
24 1 Y 1 D LYS 147 ? CD  ? D LYS 11  CD  
25 1 Y 1 D LYS 147 ? CE  ? D LYS 11  CE  
26 1 Y 1 D LYS 147 ? NZ  ? D LYS 11  NZ  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .                   1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .                   2 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .                   3 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? '(1.11.1_2575-000)' 4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   105.66 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9IWK 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     61.299 
_cell.length_a_esd                 ? 
_cell.length_b                     60.054 
_cell.length_b_esd                 ? 
_cell.length_c                     92.828 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9IWK 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                4 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1 21 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9IWK 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.39 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          48.47 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1M  Tris (pH 8.5), 30% PEG 8000, 0.2M ammonium sulfate' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      Mirrors 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2021-06-07 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    'Si(111)' 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.00000 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'PHOTON FACTORY BEAMLINE BL-17A' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.00000 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL-17A 
_diffrn_source.pdbx_synchrotron_site       'Photon Factory' 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9IWK 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.43 
_reflns.d_resolution_low                               44.69 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     24392 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           98.7 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                3.5 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          16.1 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.045 
_reflns.pdbx_Rpim_I_all                                0.024 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       85105 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.038 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.43 
_reflns_shell.d_res_low                                     2.52 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           2.8 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2536 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               3.5 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               0.467 
_reflns_shell.pdbx_Rpim_I_all                               0.244 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.897 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          97.7 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.398 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9IWK 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.430 
_refine.ls_d_res_low                             44.084 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     24381 
_refine.ls_number_reflns_R_free                  2294 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    96.89 
_refine.ls_percent_reflns_R_free                 4.93 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2397 
_refine.ls_R_factor_R_free                       0.2655 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2382 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.91 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.11 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 33.01 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.33 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.430 
_refine_hist.d_res_low                        44.084 
_refine_hist.number_atoms_solvent             0 
_refine_hist.number_atoms_total               3881 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3881 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.002  ? 3940 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.407  ? 5307 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 13.595 ? 2432 ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.035  ? 626  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.003  ? 670  ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.4303 2.4831 . . 124 2757 96.00 . . . . 0.3061 . . . . . . . . . . . 0.3232 
'X-RAY DIFFRACTION' 2.4831 2.5409 . . 158 2777 98.00 . . . . 0.3021 . . . . . . . . . . . 0.3466 
'X-RAY DIFFRACTION' 2.5409 2.6044 . . 130 2804 97.00 . . . . 0.2854 . . . . . . . . . . . 0.3505 
'X-RAY DIFFRACTION' 2.6044 2.6748 . . 110 2827 98.00 . . . . 0.2836 . . . . . . . . . . . 0.3139 
'X-RAY DIFFRACTION' 2.6748 2.7535 . . 166 2763 97.00 . . . . 0.2846 . . . . . . . . . . . 0.3142 
'X-RAY DIFFRACTION' 2.7535 2.8424 . . 136 2820 98.00 . . . . 0.2795 . . . . . . . . . . . 0.3804 
'X-RAY DIFFRACTION' 2.8424 2.9440 . . 123 2773 98.00 . . . . 0.3035 . . . . . . . . . . . 0.2884 
'X-RAY DIFFRACTION' 2.9440 3.0618 . . 148 2834 97.00 . . . . 0.3027 . . . . . . . . . . . 0.3296 
'X-RAY DIFFRACTION' 3.0618 3.2011 . . 141 2770 98.00 . . . . 0.2878 . . . . . . . . . . . 0.3175 
'X-RAY DIFFRACTION' 3.2011 3.3698 . . 143 2751 96.00 . . . . 0.2806 . . . . . . . . . . . 0.3367 
'X-RAY DIFFRACTION' 3.3698 3.5809 . . 108 2644 92.00 . . . . 0.2694 . . . . . . . . . . . 0.3395 
'X-RAY DIFFRACTION' 3.5809 3.8572 . . 153 2779 98.00 . . . . 0.2314 . . . . . . . . . . . 0.2984 
'X-RAY DIFFRACTION' 3.8572 4.2451 . . 147 2801 99.00 . . . . 0.2169 . . . . . . . . . . . 0.2173 
'X-RAY DIFFRACTION' 4.2451 4.8587 . . 164 2775 98.00 . . . . 0.2028 . . . . . . . . . . . 0.2495 
'X-RAY DIFFRACTION' 4.8587 6.1188 . . 176 2748 97.00 . . . . 0.2195 . . . . . . . . . . . 0.2483 
'X-RAY DIFFRACTION' 6.1188 44.084 . . 167 2624 93.00 . . . . 0.1848 . . . . . . . . . . . 0.1779 
# 
_struct.entry_id                     9IWK 
_struct.title                        
'X-ray structure of human PPARgamma ligand binding domain-NCoR2 corepressor peptide co-crystals obtained by co-crystallization' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9IWK 
_struct_keywords.text            'Nuclear receptor, Corepressor, PPAR, NCoR, Transcription' 
_struct_keywords.pdbx_keywords   TRANSCRIPTION 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 1 ? 
D N N 2 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP PPARG-2_HUMAN P37231-2 ? 1 
;QLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIF
QGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGD
FMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDL
RQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
;
203  
2 UNP NCOR2_HUMAN   Q9Y618   ? 2 TNMGLEAIIRKALMGKYDQWEE 2346 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9IWK A 5 ? 279 ? P37231-2 203  ? 477  ? 203 477 
2 2 9IWK B 1 ? 22  ? Q9Y618   2346 ? 2367 ? 137 158 
3 1 9IWK C 5 ? 279 ? P37231-2 203  ? 477  ? 203 477 
4 2 9IWK D 1 ? 22  ? Q9Y618   2346 ? 2367 ? 137 158 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9IWK GLY A 1 ? UNP P37231-2 ? ? 'expression tag' 199 1 
1 9IWK SER A 2 ? UNP P37231-2 ? ? 'expression tag' 200 2 
1 9IWK HIS A 3 ? UNP P37231-2 ? ? 'expression tag' 201 3 
1 9IWK MET A 4 ? UNP P37231-2 ? ? 'expression tag' 202 4 
3 9IWK GLY C 1 ? UNP P37231-2 ? ? 'expression tag' 199 5 
3 9IWK SER C 2 ? UNP P37231-2 ? ? 'expression tag' 200 6 
3 9IWK HIS C 3 ? UNP P37231-2 ? ? 'expression tag' 201 7 
3 9IWK MET C 4 ? UNP P37231-2 ? ? 'expression tag' 202 8 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_and_software_defined_assembly PISA dimeric 2 
2 author_and_software_defined_assembly PISA dimeric 2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 910   ? 
1 MORE         -8    ? 
1 'SSA (A^2)'  12570 ? 
2 'ABSA (A^2)' 1050  ? 
2 MORE         -10   ? 
2 'SSA (A^2)'  13100 ? 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,B 
2 1 C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASN A 7   ? PHE A 28  ? ASN A 205 PHE A 226 1 ? 22 
HELX_P HELX_P2  AA2 THR A 31  ? THR A 40  ? THR A 229 THR A 238 1 ? 10 
HELX_P HELX_P3  AA3 ASP A 53  ? MET A 59  ? ASP A 251 MET A 257 1 ? 7  
HELX_P HELX_P4  AA4 VAL A 92  ? LYS A 103 ? VAL A 290 LYS A 301 1 ? 12 
HELX_P HELX_P5  AA5 ASP A 112 ? LEU A 135 ? ASP A 310 LEU A 333 1 ? 24 
HELX_P HELX_P6  AA6 ARG A 152 ? SER A 157 ? ARG A 350 SER A 355 1 ? 6  
HELX_P HELX_P7  AA7 PRO A 161 ? PHE A 165 ? PRO A 359 PHE A 363 5 ? 5  
HELX_P HELX_P8  AA8 MET A 166 ? ALA A 178 ? MET A 364 ALA A 376 1 ? 13 
HELX_P HELX_P9  AA9 ASP A 182 ? LEU A 195 ? ASP A 380 LEU A 393 1 ? 14 
HELX_P HELX_P10 AB1 VAL A 205 ? HIS A 227 ? VAL A 403 HIS A 425 1 ? 23 
HELX_P HELX_P11 AB2 GLN A 232 ? GLN A 256 ? GLN A 430 GLN A 454 1 ? 25 
HELX_P HELX_P12 AB3 ILE B 8   ? LEU B 13  ? ILE B 144 LEU B 149 1 ? 6  
HELX_P HELX_P13 AB4 GLU C 9   ? PHE C 28  ? GLU C 207 PHE C 226 1 ? 20 
HELX_P HELX_P14 AB5 THR C 31  ? THR C 40  ? THR C 229 THR C 238 1 ? 10 
HELX_P HELX_P15 AB6 ASP C 53  ? GLY C 60  ? ASP C 251 GLY C 258 1 ? 8  
HELX_P HELX_P16 AB7 GLU C 78  ? LYS C 103 ? GLU C 276 LYS C 301 1 ? 26 
HELX_P HELX_P17 AB8 ASP C 112 ? TYR C 122 ? ASP C 310 TYR C 320 1 ? 11 
HELX_P HELX_P18 AB9 GLY C 123 ? ALA C 133 ? GLY C 321 ALA C 331 1 ? 11 
HELX_P HELX_P19 AC1 SER C 134 ? MET C 136 ? SER C 332 MET C 334 5 ? 3  
HELX_P HELX_P20 AC2 ARG C 152 ? SER C 157 ? ARG C 350 SER C 355 1 ? 6  
HELX_P HELX_P21 AC3 PRO C 161 ? PHE C 165 ? PRO C 359 PHE C 363 5 ? 5  
HELX_P HELX_P22 AC4 MET C 166 ? ALA C 178 ? MET C 364 ALA C 376 1 ? 13 
HELX_P HELX_P23 AC5 ASP C 182 ? LEU C 195 ? ASP C 380 LEU C 393 1 ? 14 
HELX_P HELX_P24 AC6 ASN C 204 ? HIS C 227 ? ASN C 402 HIS C 425 1 ? 24 
HELX_P HELX_P25 AC7 GLN C 232 ? THR C 261 ? GLN C 430 THR C 459 1 ? 30 
HELX_P HELX_P26 AC8 LEU D 5   ? ALA D 12  ? LEU D 141 ALA D 148 1 ? 8  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 LYS 160 A . ? LYS 358 A PRO 161 A ? PRO 359 A 1 -0.69 
2 GLU 61  C . ? GLU 259 C ASP 62  C ? ASP 260 C 1 3.27  
3 LYS 160 C . ? LYS 358 C PRO 161 C ? PRO 359 C 1 -0.48 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 3 ? 
AA2 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE A 49  ? ILE A 51  ? PHE A 247 ILE A 249 
AA1 2 GLY A 148 ? THR A 151 ? GLY A 346 THR A 349 
AA1 3 GLY A 140 ? ILE A 143 ? GLY A 338 ILE A 341 
AA2 1 PHE C 49  ? ILE C 51  ? PHE C 247 ILE C 249 
AA2 2 GLY C 148 ? THR C 151 ? GLY C 346 THR C 349 
AA2 3 GLY C 140 ? ILE C 143 ? GLY C 338 ILE C 341 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ILE A 51  ? N ILE A 249 O PHE A 149 ? O PHE A 347 
AA1 2 3 O MET A 150 ? O MET A 348 N VAL A 141 ? N VAL A 339 
AA2 1 2 N ILE C 51  ? N ILE C 249 O PHE C 149 ? O PHE C 347 
AA2 2 3 O GLY C 148 ? O GLY C 346 N ILE C 143 ? N ILE C 341 
# 
_pdbx_entry_details.entry_id                   9IWK 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 THR A 238 ? ? -93.44  -159.67 
2  1 LYS A 240 ? ? -66.94  47.06   
3  1 THR A 242 ? ? -96.35  -100.50 
4  1 ASP A 243 ? ? -88.46  -127.58 
5  1 GLU B 142 ? ? 69.49   -31.64  
6  1 ARG B 146 ? ? -69.37  63.10   
7  1 LYS B 147 ? ? -163.96 -50.95  
8  1 ASP C 260 ? ? -108.51 65.34   
9  1 LYS C 458 ? ? -108.30 -84.35  
10 1 ARG D 146 ? ? 78.74   -49.90  
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A GLY 199 ? A GLY 1   
2   1 Y 1 A SER 200 ? A SER 2   
3   1 Y 1 A HIS 201 ? A HIS 3   
4   1 Y 1 A ASP 260 ? A ASP 62  
5   1 Y 1 A LYS 261 ? A LYS 63  
6   1 Y 1 A ILE 262 ? A ILE 64  
7   1 Y 1 A LYS 263 ? A LYS 65  
8   1 Y 1 A PHE 264 ? A PHE 66  
9   1 Y 1 A LYS 265 ? A LYS 67  
10  1 Y 1 A HIS 266 ? A HIS 68  
11  1 Y 1 A ILE 267 ? A ILE 69  
12  1 Y 1 A THR 268 ? A THR 70  
13  1 Y 1 A PRO 269 ? A PRO 71  
14  1 Y 1 A LEU 270 ? A LEU 72  
15  1 Y 1 A GLN 271 ? A GLN 73  
16  1 Y 1 A GLU 272 ? A GLU 74  
17  1 Y 1 A GLN 273 ? A GLN 75  
18  1 Y 1 A SER 274 ? A SER 76  
19  1 Y 1 A LYS 275 ? A LYS 77  
20  1 Y 1 A GLU 276 ? A GLU 78  
21  1 Y 1 A VAL 277 ? A VAL 79  
22  1 Y 1 A ALA 278 ? A ALA 80  
23  1 Y 1 A ILE 279 ? A ILE 81  
24  1 Y 1 A ARG 280 ? A ARG 82  
25  1 Y 1 A ILE 281 ? A ILE 83  
26  1 Y 1 A PHE 282 ? A PHE 84  
27  1 Y 1 A GLN 283 ? A GLN 85  
28  1 Y 1 A GLY 284 ? A GLY 86  
29  1 Y 1 A CYS 285 ? A CYS 87  
30  1 Y 1 A GLN 286 ? A GLN 88  
31  1 Y 1 A PHE 287 ? A PHE 89  
32  1 Y 1 A ARG 288 ? A ARG 90  
33  1 Y 1 A ILE 456 ? A ILE 258 
34  1 Y 1 A LYS 457 ? A LYS 259 
35  1 Y 1 A LYS 458 ? A LYS 260 
36  1 Y 1 A THR 459 ? A THR 261 
37  1 Y 1 A GLU 460 ? A GLU 262 
38  1 Y 1 A THR 461 ? A THR 263 
39  1 Y 1 A ASP 462 ? A ASP 264 
40  1 Y 1 A MET 463 ? A MET 265 
41  1 Y 1 A SER 464 ? A SER 266 
42  1 Y 1 A LEU 465 ? A LEU 267 
43  1 Y 1 A HIS 466 ? A HIS 268 
44  1 Y 1 A PRO 467 ? A PRO 269 
45  1 Y 1 A LEU 468 ? A LEU 270 
46  1 Y 1 A LEU 469 ? A LEU 271 
47  1 Y 1 A GLN 470 ? A GLN 272 
48  1 Y 1 A GLU 471 ? A GLU 273 
49  1 Y 1 A ILE 472 ? A ILE 274 
50  1 Y 1 A TYR 473 ? A TYR 275 
51  1 Y 1 A LYS 474 ? A LYS 276 
52  1 Y 1 A ASP 475 ? A ASP 277 
53  1 Y 1 A LEU 476 ? A LEU 278 
54  1 Y 1 A TYR 477 ? A TYR 279 
55  1 Y 1 B THR 137 ? B THR 1   
56  1 Y 1 B ASN 138 ? B ASN 2   
57  1 Y 1 B MET 139 ? B MET 3   
58  1 Y 1 B GLY 140 ? B GLY 4   
59  1 Y 1 B MET 150 ? B MET 14  
60  1 Y 1 B GLY 151 ? B GLY 15  
61  1 Y 1 B LYS 152 ? B LYS 16  
62  1 Y 1 B TYR 153 ? B TYR 17  
63  1 Y 1 B ASP 154 ? B ASP 18  
64  1 Y 1 B GLN 155 ? B GLN 19  
65  1 Y 1 B TRP 156 ? B TRP 20  
66  1 Y 1 B GLU 157 ? B GLU 21  
67  1 Y 1 B GLU 158 ? B GLU 22  
68  1 Y 1 C GLY 199 ? C GLY 1   
69  1 Y 1 C SER 200 ? C SER 2   
70  1 Y 1 C HIS 201 ? C HIS 3   
71  1 Y 1 C MET 202 ? C MET 4   
72  1 Y 1 C GLN 203 ? C GLN 5   
73  1 Y 1 C LEU 204 ? C LEU 6   
74  1 Y 1 C ASN 205 ? C ASN 7   
75  1 Y 1 C ILE 267 ? C ILE 69  
76  1 Y 1 C THR 268 ? C THR 70  
77  1 Y 1 C PRO 269 ? C PRO 71  
78  1 Y 1 C LEU 270 ? C LEU 72  
79  1 Y 1 C GLN 271 ? C GLN 73  
80  1 Y 1 C GLU 272 ? C GLU 74  
81  1 Y 1 C GLN 273 ? C GLN 75  
82  1 Y 1 C SER 274 ? C SER 76  
83  1 Y 1 C THR 461 ? C THR 263 
84  1 Y 1 C ASP 462 ? C ASP 264 
85  1 Y 1 C MET 463 ? C MET 265 
86  1 Y 1 C SER 464 ? C SER 266 
87  1 Y 1 C LEU 465 ? C LEU 267 
88  1 Y 1 C HIS 466 ? C HIS 268 
89  1 Y 1 C PRO 467 ? C PRO 269 
90  1 Y 1 C LEU 468 ? C LEU 270 
91  1 Y 1 C LEU 469 ? C LEU 271 
92  1 Y 1 C GLN 470 ? C GLN 272 
93  1 Y 1 C GLU 471 ? C GLU 273 
94  1 Y 1 C ILE 472 ? C ILE 274 
95  1 Y 1 C TYR 473 ? C TYR 275 
96  1 Y 1 C LYS 474 ? C LYS 276 
97  1 Y 1 C ASP 475 ? C ASP 277 
98  1 Y 1 C LEU 476 ? C LEU 278 
99  1 Y 1 C TYR 477 ? C TYR 279 
100 1 Y 1 D THR 137 ? D THR 1   
101 1 Y 1 D ASN 138 ? D ASN 2   
102 1 Y 1 D MET 139 ? D MET 3   
103 1 Y 1 D MET 150 ? D MET 14  
104 1 Y 1 D GLY 151 ? D GLY 15  
105 1 Y 1 D LYS 152 ? D LYS 16  
106 1 Y 1 D TYR 153 ? D TYR 17  
107 1 Y 1 D ASP 154 ? D ASP 18  
108 1 Y 1 D GLN 155 ? D GLN 19  
109 1 Y 1 D TRP 156 ? D TRP 20  
110 1 Y 1 D GLU 157 ? D GLU 21  
111 1 Y 1 D GLU 158 ? D GLU 22  
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PHE N    N N N 247 
PHE CA   C N S 248 
PHE C    C N N 249 
PHE O    O N N 250 
PHE CB   C N N 251 
PHE CG   C Y N 252 
PHE CD1  C Y N 253 
PHE CD2  C Y N 254 
PHE CE1  C Y N 255 
PHE CE2  C Y N 256 
PHE CZ   C Y N 257 
PHE OXT  O N N 258 
PHE H    H N N 259 
PHE H2   H N N 260 
PHE HA   H N N 261 
PHE HB2  H N N 262 
PHE HB3  H N N 263 
PHE HD1  H N N 264 
PHE HD2  H N N 265 
PHE HE1  H N N 266 
PHE HE2  H N N 267 
PHE HZ   H N N 268 
PHE HXT  H N N 269 
PRO N    N N N 270 
PRO CA   C N S 271 
PRO C    C N N 272 
PRO O    O N N 273 
PRO CB   C N N 274 
PRO CG   C N N 275 
PRO CD   C N N 276 
PRO OXT  O N N 277 
PRO H    H N N 278 
PRO HA   H N N 279 
PRO HB2  H N N 280 
PRO HB3  H N N 281 
PRO HG2  H N N 282 
PRO HG3  H N N 283 
PRO HD2  H N N 284 
PRO HD3  H N N 285 
PRO HXT  H N N 286 
SER N    N N N 287 
SER CA   C N S 288 
SER C    C N N 289 
SER O    O N N 290 
SER CB   C N N 291 
SER OG   O N N 292 
SER OXT  O N N 293 
SER H    H N N 294 
SER H2   H N N 295 
SER HA   H N N 296 
SER HB2  H N N 297 
SER HB3  H N N 298 
SER HG   H N N 299 
SER HXT  H N N 300 
THR N    N N N 301 
THR CA   C N S 302 
THR C    C N N 303 
THR O    O N N 304 
THR CB   C N R 305 
THR OG1  O N N 306 
THR CG2  C N N 307 
THR OXT  O N N 308 
THR H    H N N 309 
THR H2   H N N 310 
THR HA   H N N 311 
THR HB   H N N 312 
THR HG1  H N N 313 
THR HG21 H N N 314 
THR HG22 H N N 315 
THR HG23 H N N 316 
THR HXT  H N N 317 
TRP N    N N N 318 
TRP CA   C N S 319 
TRP C    C N N 320 
TRP O    O N N 321 
TRP CB   C N N 322 
TRP CG   C Y N 323 
TRP CD1  C Y N 324 
TRP CD2  C Y N 325 
TRP NE1  N Y N 326 
TRP CE2  C Y N 327 
TRP CE3  C Y N 328 
TRP CZ2  C Y N 329 
TRP CZ3  C Y N 330 
TRP CH2  C Y N 331 
TRP OXT  O N N 332 
TRP H    H N N 333 
TRP H2   H N N 334 
TRP HA   H N N 335 
TRP HB2  H N N 336 
TRP HB3  H N N 337 
TRP HD1  H N N 338 
TRP HE1  H N N 339 
TRP HE3  H N N 340 
TRP HZ2  H N N 341 
TRP HZ3  H N N 342 
TRP HH2  H N N 343 
TRP HXT  H N N 344 
TYR N    N N N 345 
TYR CA   C N S 346 
TYR C    C N N 347 
TYR O    O N N 348 
TYR CB   C N N 349 
TYR CG   C Y N 350 
TYR CD1  C Y N 351 
TYR CD2  C Y N 352 
TYR CE1  C Y N 353 
TYR CE2  C Y N 354 
TYR CZ   C Y N 355 
TYR OH   O N N 356 
TYR OXT  O N N 357 
TYR H    H N N 358 
TYR H2   H N N 359 
TYR HA   H N N 360 
TYR HB2  H N N 361 
TYR HB3  H N N 362 
TYR HD1  H N N 363 
TYR HD2  H N N 364 
TYR HE1  H N N 365 
TYR HE2  H N N 366 
TYR HH   H N N 367 
TYR HXT  H N N 368 
VAL N    N N N 369 
VAL CA   C N S 370 
VAL C    C N N 371 
VAL O    O N N 372 
VAL CB   C N N 373 
VAL CG1  C N N 374 
VAL CG2  C N N 375 
VAL OXT  O N N 376 
VAL H    H N N 377 
VAL H2   H N N 378 
VAL HA   H N N 379 
VAL HB   H N N 380 
VAL HG11 H N N 381 
VAL HG12 H N N 382 
VAL HG13 H N N 383 
VAL HG21 H N N 384 
VAL HG22 H N N 385 
VAL HG23 H N N 386 
VAL HXT  H N N 387 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
VAL N   CA   sing N N 356 
VAL N   H    sing N N 357 
VAL N   H2   sing N N 358 
VAL CA  C    sing N N 359 
VAL CA  CB   sing N N 360 
VAL CA  HA   sing N N 361 
VAL C   O    doub N N 362 
VAL C   OXT  sing N N 363 
VAL CB  CG1  sing N N 364 
VAL CB  CG2  sing N N 365 
VAL CB  HB   sing N N 366 
VAL CG1 HG11 sing N N 367 
VAL CG1 HG12 sing N N 368 
VAL CG1 HG13 sing N N 369 
VAL CG2 HG21 sing N N 370 
VAL CG2 HG22 sing N N 371 
VAL CG2 HG23 sing N N 372 
VAL OXT HXT  sing N N 373 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Japan Society for the Promotion of Science (JSPS)'        Japan 19K16359      1 
'Japan Agency for Medical Research and Development (AMED)' Japan JP21am0101071 2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   6MS7 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9IWK 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.016313 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.004574 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.016652 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.011188 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM 1    N N   . MET A 1 4   ? -46.781 -20.386 -13.786 1.00 84.04  ? 202 MET A N   1 
ATOM 2    C CA  . MET A 1 4   ? -45.553 -21.169 -13.853 1.00 86.79  ? 202 MET A CA  1 
ATOM 3    C C   . MET A 1 4   ? -45.664 -22.447 -13.026 1.00 76.11  ? 202 MET A C   1 
ATOM 4    O O   . MET A 1 4   ? -46.498 -22.545 -12.126 1.00 60.90  ? 202 MET A O   1 
ATOM 5    C CB  . MET A 1 4   ? -44.361 -20.339 -13.376 1.00 74.61  ? 202 MET A CB  1 
ATOM 6    C CG  . MET A 1 4   ? -44.567 -19.685 -12.021 1.00 68.89  ? 202 MET A CG  1 
ATOM 7    S SD  . MET A 1 4   ? -43.021 -19.116 -11.292 1.00 85.87  ? 202 MET A SD  1 
ATOM 8    C CE  . MET A 1 4   ? -42.190 -20.682 -11.033 1.00 79.12  ? 202 MET A CE  1 
ATOM 9    N N   . GLN A 1 5   ? -44.814 -23.424 -13.338 1.00 71.10  ? 203 GLN A N   1 
ATOM 10   C CA  . GLN A 1 5   ? -44.810 -24.702 -12.643 1.00 76.47  ? 203 GLN A CA  1 
ATOM 11   C C   . GLN A 1 5   ? -43.374 -25.137 -12.387 1.00 71.79  ? 203 GLN A C   1 
ATOM 12   O O   . GLN A 1 5   ? -42.435 -24.667 -13.034 1.00 66.98  ? 203 GLN A O   1 
ATOM 13   C CB  . GLN A 1 5   ? -45.556 -25.783 -13.438 1.00 74.02  ? 203 GLN A CB  1 
ATOM 14   C CG  . GLN A 1 5   ? -47.060 -25.578 -13.514 1.00 82.78  ? 203 GLN A CG  1 
ATOM 15   C CD  . GLN A 1 5   ? -47.756 -26.669 -14.302 1.00 87.67  ? 203 GLN A CD  1 
ATOM 16   O OE1 . GLN A 1 5   ? -47.160 -27.291 -15.182 1.00 94.32  ? 203 GLN A OE1 1 
ATOM 17   N NE2 . GLN A 1 5   ? -49.023 -26.912 -13.987 1.00 85.33  ? 203 GLN A NE2 1 
ATOM 18   N N   . LEU A 1 6   ? -43.216 -26.048 -11.429 1.00 67.50  ? 204 LEU A N   1 
ATOM 19   C CA  . LEU A 1 6   ? -41.910 -26.601 -11.077 1.00 63.85  ? 204 LEU A CA  1 
ATOM 20   C C   . LEU A 1 6   ? -41.669 -27.824 -11.955 1.00 66.52  ? 204 LEU A C   1 
ATOM 21   O O   . LEU A 1 6   ? -42.127 -28.927 -11.647 1.00 69.19  ? 204 LEU A O   1 
ATOM 22   C CB  . LEU A 1 6   ? -41.854 -26.949 -9.594  1.00 62.34  ? 204 LEU A CB  1 
ATOM 23   C CG  . LEU A 1 6   ? -40.482 -27.285 -9.009  1.00 72.29  ? 204 LEU A CG  1 
ATOM 24   C CD1 . LEU A 1 6   ? -39.514 -26.128 -9.206  1.00 77.18  ? 204 LEU A CD1 1 
ATOM 25   C CD2 . LEU A 1 6   ? -40.606 -27.635 -7.535  1.00 68.56  ? 204 LEU A CD2 1 
ATOM 26   N N   . ASN A 1 7   ? -40.949 -27.626 -13.047 1.00 60.10  ? 205 ASN A N   1 
ATOM 27   C CA  . ASN A 1 7   ? -40.717 -28.639 -14.073 1.00 64.24  ? 205 ASN A CA  1 
ATOM 28   C C   . ASN A 1 7   ? -39.225 -28.728 -14.352 1.00 64.18  ? 205 ASN A C   1 
ATOM 29   O O   . ASN A 1 7   ? -38.442 -27.921 -13.849 1.00 61.54  ? 205 ASN A O   1 
ATOM 30   C CB  . ASN A 1 7   ? -41.510 -28.279 -15.342 1.00 53.92  ? 205 ASN A CB  1 
ATOM 31   C CG  . ASN A 1 7   ? -41.397 -26.816 -15.711 1.00 59.80  ? 205 ASN A CG  1 
ATOM 32   O OD1 . ASN A 1 7   ? -40.315 -26.233 -15.668 1.00 68.44  ? 205 ASN A OD1 1 
ATOM 33   N ND2 . ASN A 1 7   ? -42.523 -26.210 -16.068 1.00 76.91  ? 205 ASN A ND2 1 
ATOM 34   N N   . PRO A 1 8   ? -38.792 -29.731 -15.136 1.00 58.02  ? 206 PRO A N   1 
ATOM 35   C CA  . PRO A 1 8   ? -37.344 -29.868 -15.388 1.00 63.43  ? 206 PRO A CA  1 
ATOM 36   C C   . PRO A 1 8   ? -36.687 -28.620 -15.953 1.00 61.24  ? 206 PRO A C   1 
ATOM 37   O O   . PRO A 1 8   ? -35.529 -28.336 -15.621 1.00 65.03  ? 206 PRO A O   1 
ATOM 38   C CB  . PRO A 1 8   ? -37.279 -31.040 -16.375 1.00 66.46  ? 206 PRO A CB  1 
ATOM 39   C CG  . PRO A 1 8   ? -38.465 -31.861 -16.040 1.00 67.89  ? 206 PRO A CG  1 
ATOM 40   C CD  . PRO A 1 8   ? -39.542 -30.881 -15.676 1.00 65.58  ? 206 PRO A CD  1 
ATOM 41   N N   . GLU A 1 9   ? -37.387 -27.863 -16.801 1.00 56.20  ? 207 GLU A N   1 
ATOM 42   C CA  . GLU A 1 9   ? -36.806 -26.632 -17.327 1.00 62.30  ? 207 GLU A CA  1 
ATOM 43   C C   . GLU A 1 9   ? -36.617 -25.597 -16.224 1.00 57.47  ? 207 GLU A C   1 
ATOM 44   O O   . GLU A 1 9   ? -35.619 -24.867 -16.213 1.00 48.36  ? 207 GLU A O   1 
ATOM 45   C CB  . GLU A 1 9   ? -37.681 -26.074 -18.450 1.00 69.20  ? 207 GLU A CB  1 
ATOM 46   C CG  . GLU A 1 9   ? -37.221 -24.727 -18.986 1.00 82.48  ? 207 GLU A CG  1 
ATOM 47   C CD  . GLU A 1 9   ? -37.950 -24.321 -20.251 1.00 85.20  ? 207 GLU A CD  1 
ATOM 48   O OE1 . GLU A 1 9   ? -38.019 -25.144 -21.188 1.00 89.04  ? 207 GLU A OE1 1 
ATOM 49   O OE2 . GLU A 1 9   ? -38.459 -23.182 -20.307 1.00 93.23  ? 207 GLU A OE2 1 
ATOM 50   N N   . SER A 1 10  ? -37.560 -25.528 -15.280 1.00 52.56  ? 208 SER A N   1 
ATOM 51   C CA  . SER A 1 10  ? -37.430 -24.585 -14.174 1.00 59.01  ? 208 SER A CA  1 
ATOM 52   C C   . SER A 1 10  ? -36.291 -24.976 -13.240 1.00 59.41  ? 208 SER A C   1 
ATOM 53   O O   . SER A 1 10  ? -35.566 -24.108 -12.741 1.00 52.90  ? 208 SER A O   1 
ATOM 54   C CB  . SER A 1 10  ? -38.745 -24.496 -13.400 1.00 70.39  ? 208 SER A CB  1 
ATOM 55   O OG  . SER A 1 10  ? -39.812 -24.107 -14.247 1.00 98.32  ? 208 SER A OG  1 
ATOM 56   N N   . ALA A 1 11  ? -36.121 -26.276 -12.989 1.00 51.49  ? 209 ALA A N   1 
ATOM 57   C CA  . ALA A 1 11  ? -35.064 -26.723 -12.086 1.00 44.82  ? 209 ALA A CA  1 
ATOM 58   C C   . ALA A 1 11  ? -33.682 -26.457 -12.669 1.00 55.89  ? 209 ALA A C   1 
ATOM 59   O O   . ALA A 1 11  ? -32.743 -26.135 -11.932 1.00 57.81  ? 209 ALA A O   1 
ATOM 60   C CB  . ALA A 1 11  ? -35.238 -28.206 -11.767 1.00 51.12  ? 209 ALA A CB  1 
ATOM 61   N N   . ASP A 1 12  ? -33.538 -26.585 -13.991 1.00 49.23  ? 210 ASP A N   1 
ATOM 62   C CA  . ASP A 1 12  ? -32.260 -26.279 -14.624 1.00 51.14  ? 210 ASP A CA  1 
ATOM 63   C C   . ASP A 1 12  ? -31.953 -24.788 -14.573 1.00 50.29  ? 210 ASP A C   1 
ATOM 64   O O   . ASP A 1 12  ? -30.781 -24.402 -14.498 1.00 48.67  ? 210 ASP A O   1 
ATOM 65   C CB  . ASP A 1 12  ? -32.253 -26.776 -16.071 1.00 68.40  ? 210 ASP A CB  1 
ATOM 66   C CG  . ASP A 1 12  ? -32.095 -28.282 -16.168 1.00 71.05  ? 210 ASP A CG  1 
ATOM 67   O OD1 . ASP A 1 12  ? -31.356 -28.852 -15.337 1.00 67.31  ? 210 ASP A OD1 1 
ATOM 68   O OD2 . ASP A 1 12  ? -32.705 -28.895 -17.069 1.00 72.47  ? 210 ASP A OD2 1 
ATOM 69   N N   . LEU A 1 13  ? -32.982 -23.940 -14.614 1.00 44.96  ? 211 LEU A N   1 
ATOM 70   C CA  . LEU A 1 13  ? -32.757 -22.506 -14.458 1.00 56.79  ? 211 LEU A CA  1 
ATOM 71   C C   . LEU A 1 13  ? -32.336 -22.168 -13.034 1.00 48.42  ? 211 LEU A C   1 
ATOM 72   O O   . LEU A 1 13  ? -31.492 -21.290 -12.820 1.00 49.87  ? 211 LEU A O   1 
ATOM 73   C CB  . LEU A 1 13  ? -34.015 -21.729 -14.847 1.00 48.80  ? 211 LEU A CB  1 
ATOM 74   C CG  . LEU A 1 13  ? -34.413 -21.777 -16.323 1.00 50.95  ? 211 LEU A CG  1 
ATOM 75   C CD1 . LEU A 1 13  ? -35.721 -21.036 -16.551 1.00 44.47  ? 211 LEU A CD1 1 
ATOM 76   C CD2 . LEU A 1 13  ? -33.308 -21.198 -17.193 1.00 40.37  ? 211 LEU A CD2 1 
ATOM 77   N N   . ARG A 1 14  ? -32.914 -22.856 -12.046 1.00 49.39  ? 212 ARG A N   1 
ATOM 78   C CA  . ARG A 1 14  ? -32.508 -22.640 -10.661 1.00 46.12  ? 212 ARG A CA  1 
ATOM 79   C C   . ARG A 1 14  ? -31.107 -23.180 -10.408 1.00 50.69  ? 212 ARG A C   1 
ATOM 80   O O   . ARG A 1 14  ? -30.324 -22.569 -9.671  1.00 50.75  ? 212 ARG A O   1 
ATOM 81   C CB  . ARG A 1 14  ? -33.517 -23.285 -9.711  1.00 36.89  ? 212 ARG A CB  1 
ATOM 82   C CG  . ARG A 1 14  ? -34.920 -22.716 -9.833  1.00 50.24  ? 212 ARG A CG  1 
ATOM 83   C CD  . ARG A 1 14  ? -34.895 -21.201 -9.738  1.00 48.92  ? 212 ARG A CD  1 
ATOM 84   N NE  . ARG A 1 14  ? -34.511 -20.742 -8.406  1.00 52.10  ? 212 ARG A NE  1 
ATOM 85   C CZ  . ARG A 1 14  ? -34.001 -19.542 -8.149  1.00 53.46  ? 212 ARG A CZ  1 
ATOM 86   N NH1 . ARG A 1 14  ? -33.683 -19.206 -6.906  1.00 42.62  ? 212 ARG A NH1 1 
ATOM 87   N NH2 . ARG A 1 14  ? -33.796 -18.683 -9.137  1.00 41.44  ? 212 ARG A NH2 1 
ATOM 88   N N   . ALA A 1 15  ? -30.772 -24.324 -11.011 1.00 46.80  ? 213 ALA A N   1 
ATOM 89   C CA  . ALA A 1 15  ? -29.411 -24.840 -10.905 1.00 50.04  ? 213 ALA A CA  1 
ATOM 90   C C   . ALA A 1 15  ? -28.413 -23.908 -11.576 1.00 41.95  ? 213 ALA A C   1 
ATOM 91   O O   . ALA A 1 15  ? -27.271 -23.785 -11.117 1.00 57.25  ? 213 ALA A O   1 
ATOM 92   C CB  . ALA A 1 15  ? -29.328 -26.240 -11.514 1.00 50.07  ? 213 ALA A CB  1 
ATOM 93   N N   . LEU A 1 16  ? -28.821 -23.245 -12.660 1.00 45.55  ? 214 LEU A N   1 
ATOM 94   C CA  . LEU A 1 16  ? -27.966 -22.237 -13.276 1.00 47.84  ? 214 LEU A CA  1 
ATOM 95   C C   . LEU A 1 16  ? -27.812 -21.024 -12.367 1.00 39.82  ? 214 LEU A C   1 
ATOM 96   O O   . LEU A 1 16  ? -26.735 -20.420 -12.304 1.00 46.82  ? 214 LEU A O   1 
ATOM 97   C CB  . LEU A 1 16  ? -28.537 -21.827 -14.633 1.00 44.98  ? 214 LEU A CB  1 
ATOM 98   C CG  . LEU A 1 16  ? -27.821 -20.701 -15.382 1.00 55.73  ? 214 LEU A CG  1 
ATOM 99   C CD1 . LEU A 1 16  ? -26.367 -21.064 -15.641 1.00 47.42  ? 214 LEU A CD1 1 
ATOM 100  C CD2 . LEU A 1 16  ? -28.538 -20.387 -16.687 1.00 52.23  ? 214 LEU A CD2 1 
ATOM 101  N N   . ALA A 1 17  ? -28.879 -20.655 -11.653 1.00 39.30  ? 215 ALA A N   1 
ATOM 102  C CA  . ALA A 1 17  ? -28.794 -19.543 -10.713 1.00 50.92  ? 215 ALA A CA  1 
ATOM 103  C C   . ALA A 1 17  ? -27.868 -19.871 -9.550  1.00 43.92  ? 215 ALA A C   1 
ATOM 104  O O   . ALA A 1 17  ? -27.073 -19.025 -9.124  1.00 44.36  ? 215 ALA A O   1 
ATOM 105  C CB  . ALA A 1 17  ? -30.189 -19.182 -10.202 1.00 44.00  ? 215 ALA A CB  1 
ATOM 106  N N   . LYS A 1 18  ? -27.955 -21.096 -9.024  1.00 43.44  ? 216 LYS A N   1 
ATOM 107  C CA  . LYS A 1 18  ? -27.092 -21.490 -7.915  1.00 44.08  ? 216 LYS A CA  1 
ATOM 108  C C   . LYS A 1 18  ? -25.631 -21.546 -8.343  1.00 52.18  ? 216 LYS A C   1 
ATOM 109  O O   . LYS A 1 18  ? -24.741 -21.149 -7.581  1.00 59.91  ? 216 LYS A O   1 
ATOM 110  C CB  . LYS A 1 18  ? -27.543 -22.841 -7.357  1.00 50.46  ? 216 LYS A CB  1 
ATOM 111  C CG  . LYS A 1 18  ? -26.675 -23.374 -6.229  1.00 55.92  ? 216 LYS A CG  1 
ATOM 112  C CD  . LYS A 1 18  ? -26.662 -22.426 -5.040  1.00 70.04  ? 216 LYS A CD  1 
ATOM 113  C CE  . LYS A 1 18  ? -25.823 -22.984 -3.901  1.00 73.67  ? 216 LYS A CE  1 
ATOM 114  N NZ  . LYS A 1 18  ? -25.783 -22.061 -2.732  1.00 54.74  ? 216 LYS A NZ  1 
ATOM 115  N N   . HIS A 1 19  ? -25.364 -22.033 -9.557  1.00 54.47  ? 217 HIS A N   1 
ATOM 116  C CA  . HIS A 1 19  ? -23.988 -22.098 -10.042 1.00 50.44  ? 217 HIS A CA  1 
ATOM 117  C C   . HIS A 1 19  ? -23.393 -20.705 -10.202 1.00 52.43  ? 217 HIS A C   1 
ATOM 118  O O   . HIS A 1 19  ? -22.237 -20.469 -9.830  1.00 61.45  ? 217 HIS A O   1 
ATOM 119  C CB  . HIS A 1 19  ? -23.931 -22.857 -11.366 1.00 47.51  ? 217 HIS A CB  1 
ATOM 120  C CG  . HIS A 1 19  ? -22.600 -22.779 -12.048 1.00 54.64  ? 217 HIS A CG  1 
ATOM 121  N ND1 . HIS A 1 19  ? -21.506 -23.506 -11.631 1.00 60.03  ? 217 HIS A ND1 1 
ATOM 122  C CD2 . HIS A 1 19  ? -22.185 -22.052 -13.112 1.00 65.15  ? 217 HIS A CD2 1 
ATOM 123  C CE1 . HIS A 1 19  ? -20.475 -23.235 -12.412 1.00 58.73  ? 217 HIS A CE1 1 
ATOM 124  N NE2 . HIS A 1 19  ? -20.861 -22.355 -13.319 1.00 60.85  ? 217 HIS A NE2 1 
ATOM 125  N N   . LEU A 1 20  ? -24.166 -19.770 -10.758 1.00 51.77  ? 218 LEU A N   1 
ATOM 126  C CA  . LEU A 1 20  ? -23.675 -18.405 -10.911 1.00 50.88  ? 218 LEU A CA  1 
ATOM 127  C C   . LEU A 1 20  ? -23.490 -17.721 -9.563  1.00 42.93  ? 218 LEU A C   1 
ATOM 128  O O   . LEU A 1 20  ? -22.581 -16.897 -9.409  1.00 46.51  ? 218 LEU A O   1 
ATOM 129  C CB  . LEU A 1 20  ? -24.630 -17.598 -11.790 1.00 55.59  ? 218 LEU A CB  1 
ATOM 130  C CG  . LEU A 1 20  ? -24.726 -18.032 -13.254 1.00 46.85  ? 218 LEU A CG  1 
ATOM 131  C CD1 . LEU A 1 20  ? -25.834 -17.273 -13.965 1.00 39.26  ? 218 LEU A CD1 1 
ATOM 132  C CD2 . LEU A 1 20  ? -23.395 -17.826 -13.959 1.00 49.41  ? 218 LEU A CD2 1 
ATOM 133  N N   . TYR A 1 21  ? -24.332 -18.046 -8.580  1.00 52.58  ? 219 TYR A N   1 
ATOM 134  C CA  . TYR A 1 21  ? -24.190 -17.442 -7.259  1.00 50.63  ? 219 TYR A CA  1 
ATOM 135  C C   . TYR A 1 21  ? -22.924 -17.923 -6.563  1.00 48.56  ? 219 TYR A C   1 
ATOM 136  O O   . TYR A 1 21  ? -22.209 -17.125 -5.945  1.00 54.15  ? 219 TYR A O   1 
ATOM 137  C CB  . TYR A 1 21  ? -25.419 -17.746 -6.404  1.00 48.53  ? 219 TYR A CB  1 
ATOM 138  C CG  . TYR A 1 21  ? -25.281 -17.290 -4.969  1.00 50.85  ? 219 TYR A CG  1 
ATOM 139  C CD1 . TYR A 1 21  ? -25.371 -15.945 -4.636  1.00 52.91  ? 219 TYR A CD1 1 
ATOM 140  C CD2 . TYR A 1 21  ? -25.058 -18.204 -3.947  1.00 48.31  ? 219 TYR A CD2 1 
ATOM 141  C CE1 . TYR A 1 21  ? -25.243 -15.522 -3.327  1.00 51.93  ? 219 TYR A CE1 1 
ATOM 142  C CE2 . TYR A 1 21  ? -24.929 -17.791 -2.634  1.00 58.03  ? 219 TYR A CE2 1 
ATOM 143  C CZ  . TYR A 1 21  ? -25.023 -16.449 -2.331  1.00 51.54  ? 219 TYR A CZ  1 
ATOM 144  O OH  . TYR A 1 21  ? -24.895 -16.030 -1.026  1.00 56.66  ? 219 TYR A OH  1 
ATOM 145  N N   . ASP A 1 22  ? -22.632 -19.223 -6.646  1.00 51.52  ? 220 ASP A N   1 
ATOM 146  C CA  . ASP A 1 22  ? -21.417 -19.747 -6.027  1.00 53.26  ? 220 ASP A CA  1 
ATOM 147  C C   . ASP A 1 22  ? -20.173 -19.138 -6.660  1.00 57.07  ? 220 ASP A C   1 
ATOM 148  O O   . ASP A 1 22  ? -19.190 -18.851 -5.966  1.00 61.11  ? 220 ASP A O   1 
ATOM 149  C CB  . ASP A 1 22  ? -21.387 -21.271 -6.135  1.00 48.12  ? 220 ASP A CB  1 
ATOM 150  C CG  . ASP A 1 22  ? -22.533 -21.929 -5.393  1.00 56.81  ? 220 ASP A CG  1 
ATOM 151  O OD1 . ASP A 1 22  ? -23.037 -21.327 -4.421  1.00 64.18  ? 220 ASP A OD1 1 
ATOM 152  O OD2 . ASP A 1 22  ? -22.930 -23.048 -5.780  1.00 69.37  ? 220 ASP A OD2 1 
ATOM 153  N N   . SER A 1 23  ? -20.196 -18.931 -7.978  1.00 50.35  ? 221 SER A N   1 
ATOM 154  C CA  . SER A 1 23  ? -19.085 -18.252 -8.636  1.00 53.21  ? 221 SER A CA  1 
ATOM 155  C C   . SER A 1 23  ? -19.056 -16.770 -8.288  1.00 54.77  ? 221 SER A C   1 
ATOM 156  O O   . SER A 1 23  ? -17.978 -16.166 -8.243  1.00 56.22  ? 221 SER A O   1 
ATOM 157  C CB  . SER A 1 23  ? -19.178 -18.443 -10.148 1.00 45.74  ? 221 SER A CB  1 
ATOM 158  O OG  . SER A 1 23  ? -19.218 -19.818 -10.485 1.00 71.14  ? 221 SER A OG  1 
ATOM 159  N N   . TYR A 1 24  ? -20.225 -16.172 -8.048  1.00 55.14  ? 222 TYR A N   1 
ATOM 160  C CA  . TYR A 1 24  ? -20.280 -14.783 -7.606  1.00 51.04  ? 222 TYR A CA  1 
ATOM 161  C C   . TYR A 1 24  ? -19.583 -14.611 -6.262  1.00 50.39  ? 222 TYR A C   1 
ATOM 162  O O   . TYR A 1 24  ? -18.929 -13.590 -6.018  1.00 61.10  ? 222 TYR A O   1 
ATOM 163  C CB  . TYR A 1 24  ? -21.739 -14.329 -7.529  1.00 49.08  ? 222 TYR A CB  1 
ATOM 164  C CG  . TYR A 1 24  ? -21.957 -12.910 -7.050  1.00 50.43  ? 222 TYR A CG  1 
ATOM 165  C CD1 . TYR A 1 24  ? -21.963 -11.848 -7.945  1.00 46.97  ? 222 TYR A CD1 1 
ATOM 166  C CD2 . TYR A 1 24  ? -22.185 -12.637 -5.707  1.00 51.99  ? 222 TYR A CD2 1 
ATOM 167  C CE1 . TYR A 1 24  ? -22.172 -10.550 -7.512  1.00 52.70  ? 222 TYR A CE1 1 
ATOM 168  C CE2 . TYR A 1 24  ? -22.394 -11.344 -5.266  1.00 46.97  ? 222 TYR A CE2 1 
ATOM 169  C CZ  . TYR A 1 24  ? -22.387 -10.305 -6.172  1.00 48.66  ? 222 TYR A CZ  1 
ATOM 170  O OH  . TYR A 1 24  ? -22.596 -9.017  -5.736  1.00 52.08  ? 222 TYR A OH  1 
ATOM 171  N N   . ILE A 1 25  ? -19.706 -15.605 -5.381  1.00 55.53  ? 223 ILE A N   1 
ATOM 172  C CA  . ILE A 1 25  ? -19.050 -15.543 -4.080  1.00 54.47  ? 223 ILE A CA  1 
ATOM 173  C C   . ILE A 1 25  ? -17.556 -15.810 -4.212  1.00 55.16  ? 223 ILE A C   1 
ATOM 174  O O   . ILE A 1 25  ? -16.735 -15.121 -3.597  1.00 61.67  ? 223 ILE A O   1 
ATOM 175  C CB  . ILE A 1 25  ? -19.718 -16.532 -3.107  1.00 54.70  ? 223 ILE A CB  1 
ATOM 176  C CG1 . ILE A 1 25  ? -21.195 -16.178 -2.910  1.00 50.17  ? 223 ILE A CG1 1 
ATOM 177  C CG2 . ILE A 1 25  ? -18.993 -16.545 -1.770  1.00 58.70  ? 223 ILE A CG2 1 
ATOM 178  C CD1 . ILE A 1 25  ? -21.419 -14.864 -2.200  1.00 41.72  ? 223 ILE A CD1 1 
ATOM 179  N N   . LYS A 1 26  ? -17.179 -16.809 -5.018  1.00 56.88  ? 224 LYS A N   1 
ATOM 180  C CA  . LYS A 1 26  ? -15.767 -17.154 -5.162  1.00 54.77  ? 224 LYS A CA  1 
ATOM 181  C C   . LYS A 1 26  ? -14.970 -16.044 -5.834  1.00 57.96  ? 224 LYS A C   1 
ATOM 182  O O   . LYS A 1 26  ? -13.788 -15.860 -5.523  1.00 68.94  ? 224 LYS A O   1 
ATOM 183  C CB  . LYS A 1 26  ? -15.614 -18.452 -5.957  1.00 55.23  ? 224 LYS A CB  1 
ATOM 184  C CG  . LYS A 1 26  ? -16.139 -19.697 -5.264  1.00 67.33  ? 224 LYS A CG  1 
ATOM 185  C CD  . LYS A 1 26  ? -15.812 -20.944 -6.076  1.00 77.14  ? 224 LYS A CD  1 
ATOM 186  C CE  . LYS A 1 26  ? -16.320 -22.207 -5.396  1.00 77.63  ? 224 LYS A CE  1 
ATOM 187  N NZ  . LYS A 1 26  ? -17.807 -22.244 -5.315  1.00 86.58  ? 224 LYS A NZ  1 
ATOM 188  N N   . SER A 1 27  ? -15.588 -15.301 -6.753  1.00 57.91  ? 225 SER A N   1 
ATOM 189  C CA  . SER A 1 27  ? -14.835 -14.329 -7.536  1.00 56.42  ? 225 SER A CA  1 
ATOM 190  C C   . SER A 1 27  ? -14.707 -12.984 -6.833  1.00 55.79  ? 225 SER A C   1 
ATOM 191  O O   . SER A 1 27  ? -13.680 -12.311 -6.981  1.00 68.02  ? 225 SER A O   1 
ATOM 192  C CB  . SER A 1 27  ? -15.487 -14.143 -8.905  1.00 53.29  ? 225 SER A CB  1 
ATOM 193  O OG  . SER A 1 27  ? -15.529 -15.367 -9.613  1.00 54.05  ? 225 SER A OG  1 
ATOM 194  N N   . PHE A 1 28  ? -15.719 -12.576 -6.069  1.00 49.14  ? 226 PHE A N   1 
ATOM 195  C CA  . PHE A 1 28  ? -15.720 -11.253 -5.466  1.00 62.20  ? 226 PHE A CA  1 
ATOM 196  C C   . PHE A 1 28  ? -15.615 -11.355 -3.953  1.00 64.82  ? 226 PHE A C   1 
ATOM 197  O O   . PHE A 1 28  ? -16.407 -12.072 -3.327  1.00 72.61  ? 226 PHE A O   1 
ATOM 198  C CB  . PHE A 1 28  ? -16.990 -10.489 -5.855  1.00 61.24  ? 226 PHE A CB  1 
ATOM 199  C CG  . PHE A 1 28  ? -17.209 -10.402 -7.339  1.00 54.25  ? 226 PHE A CG  1 
ATOM 200  C CD1 . PHE A 1 28  ? -16.416 -9.577  -8.121  1.00 63.04  ? 226 PHE A CD1 1 
ATOM 201  C CD2 . PHE A 1 28  ? -18.204 -11.144 -7.952  1.00 51.47  ? 226 PHE A CD2 1 
ATOM 202  C CE1 . PHE A 1 28  ? -16.611 -9.495  -9.486  1.00 62.49  ? 226 PHE A CE1 1 
ATOM 203  C CE2 . PHE A 1 28  ? -18.406 -11.066 -9.319  1.00 60.12  ? 226 PHE A CE2 1 
ATOM 204  C CZ  . PHE A 1 28  ? -17.607 -10.239 -10.087 1.00 57.73  ? 226 PHE A CZ  1 
ATOM 205  N N   . PRO A 1 29  ? -14.658 -10.657 -3.335  1.00 56.54  ? 227 PRO A N   1 
ATOM 206  C CA  . PRO A 1 29  ? -14.498 -10.747 -1.877  1.00 70.60  ? 227 PRO A CA  1 
ATOM 207  C C   . PRO A 1 29  ? -15.635 -10.080 -1.120  1.00 69.75  ? 227 PRO A C   1 
ATOM 208  O O   . PRO A 1 29  ? -16.268 -10.701 -0.260  1.00 59.58  ? 227 PRO A O   1 
ATOM 209  C CB  . PRO A 1 29  ? -13.165 -10.029 -1.621  1.00 79.64  ? 227 PRO A CB  1 
ATOM 210  C CG  . PRO A 1 29  ? -12.494 -9.939  -2.964  1.00 69.84  ? 227 PRO A CG  1 
ATOM 211  C CD  . PRO A 1 29  ? -13.603 -9.843  -3.957  1.00 74.08  ? 227 PRO A CD  1 
ATOM 212  N N   . LEU A 1 30  ? -15.901 -8.814  -1.432  1.00 63.16  ? 228 LEU A N   1 
ATOM 213  C CA  . LEU A 1 30  ? -16.909 -8.021  -0.732  1.00 58.31  ? 228 LEU A CA  1 
ATOM 214  C C   . LEU A 1 30  ? -18.207 -8.071  -1.531  1.00 59.27  ? 228 LEU A C   1 
ATOM 215  O O   . LEU A 1 30  ? -18.343 -7.406  -2.562  1.00 62.10  ? 228 LEU A O   1 
ATOM 216  C CB  . LEU A 1 30  ? -16.425 -6.588  -0.536  1.00 45.18  ? 228 LEU A CB  1 
ATOM 217  C CG  . LEU A 1 30  ? -17.353 -5.652  0.240   1.00 53.80  ? 228 LEU A CG  1 
ATOM 218  C CD1 . LEU A 1 30  ? -17.742 -6.266  1.574   1.00 50.15  ? 228 LEU A CD1 1 
ATOM 219  C CD2 . LEU A 1 30  ? -16.689 -4.300  0.445   1.00 51.77  ? 228 LEU A CD2 1 
ATOM 220  N N   . THR A 1 31  ? -19.162 -8.863  -1.051  1.00 57.58  ? 229 THR A N   1 
ATOM 221  C CA  . THR A 1 31  ? -20.471 -8.964  -1.673  1.00 62.98  ? 229 THR A CA  1 
ATOM 222  C C   . THR A 1 31  ? -21.408 -7.913  -1.082  1.00 60.44  ? 229 THR A C   1 
ATOM 223  O O   . THR A 1 31  ? -21.049 -7.166  -0.169  1.00 53.99  ? 229 THR A O   1 
ATOM 224  C CB  . THR A 1 31  ? -21.040 -10.370 -1.496  1.00 51.95  ? 229 THR A CB  1 
ATOM 225  O OG1 . THR A 1 31  ? -21.180 -10.657 -0.099  1.00 57.46  ? 229 THR A OG1 1 
ATOM 226  C CG2 . THR A 1 31  ? -20.116 -11.399 -2.129  1.00 55.54  ? 229 THR A CG2 1 
ATOM 227  N N   . LYS A 1 32  ? -22.635 -7.855  -1.606  1.00 55.08  ? 230 LYS A N   1 
ATOM 228  C CA  . LYS A 1 32  ? -23.590 -6.872  -1.105  1.00 54.15  ? 230 LYS A CA  1 
ATOM 229  C C   . LYS A 1 32  ? -24.070 -7.230  0.296   1.00 46.39  ? 230 LYS A C   1 
ATOM 230  O O   . LYS A 1 32  ? -24.225 -6.346  1.146   1.00 56.37  ? 230 LYS A O   1 
ATOM 231  C CB  . LYS A 1 32  ? -24.778 -6.743  -2.058  1.00 41.05  ? 230 LYS A CB  1 
ATOM 232  C CG  . LYS A 1 32  ? -25.788 -5.697  -1.611  1.00 39.27  ? 230 LYS A CG  1 
ATOM 233  C CD  . LYS A 1 32  ? -26.917 -5.514  -2.609  1.00 46.69  ? 230 LYS A CD  1 
ATOM 234  C CE  . LYS A 1 32  ? -27.889 -4.446  -2.129  1.00 34.67  ? 230 LYS A CE  1 
ATOM 235  N NZ  . LYS A 1 32  ? -29.032 -4.259  -3.064  1.00 45.86  ? 230 LYS A NZ  1 
ATOM 236  N N   . ALA A 1 33  ? -24.305 -8.519  0.556   1.00 49.11  ? 231 ALA A N   1 
ATOM 237  C CA  . ALA A 1 33  ? -24.801 -8.935  1.865   1.00 47.45  ? 231 ALA A CA  1 
ATOM 238  C C   . ALA A 1 33  ? -23.848 -8.518  2.978   1.00 54.36  ? 231 ALA A C   1 
ATOM 239  O O   . ALA A 1 33  ? -24.286 -8.070  4.045   1.00 52.33  ? 231 ALA A O   1 
ATOM 240  C CB  . ALA A 1 33  ? -25.025 -10.447 1.888   1.00 33.75  ? 231 ALA A CB  1 
ATOM 241  N N   . LYS A 1 34  ? -22.541 -8.655  2.750   1.00 48.87  ? 232 LYS A N   1 
ATOM 242  C CA  . LYS A 1 34  ? -21.571 -8.178  3.727   1.00 54.89  ? 232 LYS A CA  1 
ATOM 243  C C   . LYS A 1 34  ? -21.411 -6.665  3.674   1.00 58.11  ? 232 LYS A C   1 
ATOM 244  O O   . LYS A 1 34  ? -21.089 -6.046  4.693   1.00 53.17  ? 232 LYS A O   1 
ATOM 245  C CB  . LYS A 1 34  ? -20.219 -8.859  3.508   1.00 61.11  ? 232 LYS A CB  1 
ATOM 246  C CG  . LYS A 1 34  ? -20.224 -10.351 3.797   1.00 78.94  ? 232 LYS A CG  1 
ATOM 247  C CD  . LYS A 1 34  ? -18.831 -10.943 3.670   1.00 88.91  ? 232 LYS A CD  1 
ATOM 248  C CE  . LYS A 1 34  ? -18.282 -10.765 2.265   1.00 87.20  ? 232 LYS A CE  1 
ATOM 249  N NZ  . LYS A 1 34  ? -19.128 -11.448 1.248   1.00 96.93  ? 232 LYS A NZ  1 
ATOM 250  N N   . ALA A 1 35  ? -21.633 -6.057  2.506   1.00 54.27  ? 233 ALA A N   1 
ATOM 251  C CA  . ALA A 1 35  ? -21.549 -4.605  2.401   1.00 50.62  ? 233 ALA A CA  1 
ATOM 252  C C   . ALA A 1 35  ? -22.677 -3.934  3.175   1.00 49.70  ? 233 ALA A C   1 
ATOM 253  O O   . ALA A 1 35  ? -22.441 -3.000  3.949   1.00 44.41  ? 233 ALA A O   1 
ATOM 254  C CB  . ALA A 1 35  ? -21.573 -4.179  0.933   1.00 50.42  ? 233 ALA A CB  1 
ATOM 255  N N   . ARG A 1 36  ? -23.914 -4.400  2.978   1.00 44.56  ? 234 ARG A N   1 
ATOM 256  C CA  . ARG A 1 36  ? -25.037 -3.819  3.706   1.00 50.46  ? 234 ARG A CA  1 
ATOM 257  C C   . ARG A 1 36  ? -24.928 -4.081  5.202   1.00 65.39  ? 234 ARG A C   1 
ATOM 258  O O   . ARG A 1 36  ? -25.370 -3.254  6.007   1.00 56.61  ? 234 ARG A O   1 
ATOM 259  C CB  . ARG A 1 36  ? -26.363 -4.361  3.170   1.00 57.50  ? 234 ARG A CB  1 
ATOM 260  C CG  . ARG A 1 36  ? -26.510 -4.303  1.656   1.00 57.39  ? 234 ARG A CG  1 
ATOM 261  C CD  . ARG A 1 36  ? -26.175 -2.931  1.093   1.00 57.21  ? 234 ARG A CD  1 
ATOM 262  N NE  . ARG A 1 36  ? -27.159 -1.918  1.463   1.00 67.10  ? 234 ARG A NE  1 
ATOM 263  C CZ  . ARG A 1 36  ? -27.169 -0.681  0.977   1.00 60.52  ? 234 ARG A CZ  1 
ATOM 264  N NH1 . ARG A 1 36  ? -26.249 -0.305  0.099   1.00 49.40  ? 234 ARG A NH1 1 
ATOM 265  N NH2 . ARG A 1 36  ? -28.100 0.179   1.366   1.00 62.66  ? 234 ARG A NH2 1 
ATOM 266  N N   . ALA A 1 37  ? -24.348 -5.219  5.592   1.00 57.30  ? 235 ALA A N   1 
ATOM 267  C CA  . ALA A 1 37  ? -24.134 -5.488  7.010   1.00 63.24  ? 235 ALA A CA  1 
ATOM 268  C C   . ALA A 1 37  ? -23.179 -4.471  7.620   1.00 60.07  ? 235 ALA A C   1 
ATOM 269  O O   . ALA A 1 37  ? -23.386 -4.012  8.749   1.00 51.60  ? 235 ALA A O   1 
ATOM 270  C CB  . ALA A 1 37  ? -23.604 -6.909  7.203   1.00 61.34  ? 235 ALA A CB  1 
ATOM 271  N N   . ILE A 1 38  ? -22.131 -4.100  6.883   1.00 54.47  ? 236 ILE A N   1 
ATOM 272  C CA  . ILE A 1 38  ? -21.197 -3.090  7.368   1.00 46.35  ? 236 ILE A CA  1 
ATOM 273  C C   . ILE A 1 38  ? -21.869 -1.723  7.428   1.00 57.25  ? 236 ILE A C   1 
ATOM 274  O O   . ILE A 1 38  ? -21.704 -0.977  8.401   1.00 71.10  ? 236 ILE A O   1 
ATOM 275  C CB  . ILE A 1 38  ? -19.938 -3.065  6.483   1.00 41.97  ? 236 ILE A CB  1 
ATOM 276  C CG1 . ILE A 1 38  ? -19.148 -4.367  6.634   1.00 51.48  ? 236 ILE A CG1 1 
ATOM 277  C CG2 . ILE A 1 38  ? -19.068 -1.868  6.820   1.00 52.94  ? 236 ILE A CG2 1 
ATOM 278  C CD1 . ILE A 1 38  ? -17.920 -4.437  5.752   1.00 43.85  ? 236 ILE A CD1 1 
ATOM 279  N N   . LEU A 1 39  ? -22.644 -1.376  6.396   1.00 60.52  ? 237 LEU A N   1 
ATOM 280  C CA  . LEU A 1 39  ? -23.273 -0.060  6.344   1.00 56.79  ? 237 LEU A CA  1 
ATOM 281  C C   . LEU A 1 39  ? -24.374 0.088   7.388   1.00 65.28  ? 237 LEU A C   1 
ATOM 282  O O   . LEU A 1 39  ? -24.583 1.188   7.912   1.00 64.01  ? 237 LEU A O   1 
ATOM 283  C CB  . LEU A 1 39  ? -23.831 0.199   4.943   1.00 58.81  ? 237 LEU A CB  1 
ATOM 284  C CG  . LEU A 1 39  ? -22.808 0.243   3.803   1.00 52.29  ? 237 LEU A CG  1 
ATOM 285  C CD1 . LEU A 1 39  ? -23.505 0.385   2.460   1.00 52.14  ? 237 LEU A CD1 1 
ATOM 286  C CD2 . LEU A 1 39  ? -21.814 1.373   4.018   1.00 46.26  ? 237 LEU A CD2 1 
ATOM 287  N N   . THR A 1 40  ? -25.079 -0.995  7.710   1.00 65.42  ? 238 THR A N   1 
ATOM 288  C CA  . THR A 1 40  ? -26.169 -0.941  8.673   1.00 65.11  ? 238 THR A CA  1 
ATOM 289  C C   . THR A 1 40  ? -25.638 -1.294  10.067  1.00 68.33  ? 238 THR A C   1 
ATOM 290  O O   . THR A 1 40  ? -24.436 -1.207  10.330  1.00 61.59  ? 238 THR A O   1 
ATOM 291  C CB  . THR A 1 40  ? -27.315 -1.855  8.220   1.00 63.13  ? 238 THR A CB  1 
ATOM 292  O OG1 . THR A 1 40  ? -26.851 -3.205  8.118   1.00 64.24  ? 238 THR A OG1 1 
ATOM 293  C CG2 . THR A 1 40  ? -27.852 -1.408  6.863   1.00 68.32  ? 238 THR A CG2 1 
ATOM 294  N N   . GLY A 1 41  ? -26.530 -1.698  10.974  1.00 75.69  ? 239 GLY A N   1 
ATOM 295  C CA  . GLY A 1 41  ? -26.128 -1.921  12.354  1.00 101.62 ? 239 GLY A CA  1 
ATOM 296  C C   . GLY A 1 41  ? -25.388 -3.228  12.566  1.00 89.09  ? 239 GLY A C   1 
ATOM 297  O O   . GLY A 1 41  ? -24.385 -3.268  13.283  1.00 85.29  ? 239 GLY A O   1 
ATOM 298  N N   . LYS A 1 42  ? -25.849 -4.304  11.929  1.00 86.47  ? 240 LYS A N   1 
ATOM 299  C CA  . LYS A 1 42  ? -25.278 -5.637  12.111  1.00 76.88  ? 240 LYS A CA  1 
ATOM 300  C C   . LYS A 1 42  ? -23.855 -5.735  11.566  1.00 77.50  ? 240 LYS A C   1 
ATOM 301  O O   . LYS A 1 42  ? -23.520 -6.696  10.864  1.00 88.64  ? 240 LYS A O   1 
ATOM 302  C CB  . LYS A 1 42  ? -26.171 -6.684  11.436  1.00 66.61  ? 240 LYS A CB  1 
ATOM 303  N N   . THR A 1 43  ? -23.010 -4.759  11.897  1.00 87.64  ? 241 THR A N   1 
ATOM 304  C CA  . THR A 1 43  ? -21.662 -4.697  11.352  1.00 91.85  ? 241 THR A CA  1 
ATOM 305  C C   . THR A 1 43  ? -20.831 -5.884  11.828  1.00 95.69  ? 241 THR A C   1 
ATOM 306  O O   . THR A 1 43  ? -21.143 -6.540  12.824  1.00 90.54  ? 241 THR A O   1 
ATOM 307  C CB  . THR A 1 43  ? -20.973 -3.395  11.759  1.00 94.14  ? 241 THR A CB  1 
ATOM 308  O OG1 . THR A 1 43  ? -19.669 -3.336  11.165  1.00 96.02  ? 241 THR A OG1 1 
ATOM 309  C CG2 . THR A 1 43  ? -20.832 -3.329  13.269  1.00 82.79  ? 241 THR A CG2 1 
ATOM 310  N N   . THR A 1 44  ? -19.743 -6.142  11.106  1.00 96.87  ? 242 THR A N   1 
ATOM 311  C CA  . THR A 1 44  ? -18.939 -7.327  11.371  1.00 98.14  ? 242 THR A CA  1 
ATOM 312  C C   . THR A 1 44  ? -17.754 -6.994  12.273  1.00 92.46  ? 242 THR A C   1 
ATOM 313  O O   . THR A 1 44  ? -17.912 -6.872  13.494  1.00 94.57  ? 242 THR A O   1 
ATOM 314  C CB  . THR A 1 44  ? -18.481 -7.960  10.047  1.00 96.88  ? 242 THR A CB  1 
ATOM 315  O OG1 . THR A 1 44  ? -17.064 -7.814  9.880   1.00 95.25  ? 242 THR A OG1 1 
ATOM 316  C CG2 . THR A 1 44  ? -19.194 -7.303  8.876   1.00 81.10  ? 242 THR A CG2 1 
ATOM 317  N N   . ASP A 1 45  ? -16.569 -6.837  11.685  1.00 88.94  ? 243 ASP A N   1 
ATOM 318  C CA  . ASP A 1 45  ? -15.342 -6.690  12.456  1.00 107.87 ? 243 ASP A CA  1 
ATOM 319  C C   . ASP A 1 45  ? -15.063 -5.232  12.804  1.00 105.67 ? 243 ASP A C   1 
ATOM 320  O O   . ASP A 1 45  ? -15.921 -4.536  13.360  1.00 99.82  ? 243 ASP A O   1 
ATOM 321  C CB  . ASP A 1 45  ? -14.169 -7.281  11.674  1.00 105.91 ? 243 ASP A CB  1 
ATOM 322  C CG  . ASP A 1 45  ? -13.057 -7.785  12.576  1.00 115.47 ? 243 ASP A CG  1 
ATOM 323  O OD1 . ASP A 1 45  ? -13.274 -7.869  13.803  1.00 117.04 ? 243 ASP A OD1 1 
ATOM 324  O OD2 . ASP A 1 45  ? -11.967 -8.099  12.055  1.00 116.00 ? 243 ASP A OD2 1 
ATOM 325  N N   . LYS A 1 46  ? -13.857 -4.773  12.485  1.00 113.80 ? 244 LYS A N   1 
ATOM 326  C CA  . LYS A 1 46  ? -13.457 -3.407  12.786  1.00 114.46 ? 244 LYS A CA  1 
ATOM 327  C C   . LYS A 1 46  ? -14.287 -2.420  11.976  1.00 110.21 ? 244 LYS A C   1 
ATOM 328  O O   . LYS A 1 46  ? -14.495 -2.599  10.773  1.00 99.26  ? 244 LYS A O   1 
ATOM 329  C CB  . LYS A 1 46  ? -11.969 -3.228  12.487  1.00 112.94 ? 244 LYS A CB  1 
ATOM 330  C CG  . LYS A 1 46  ? -11.299 -2.065  13.194  1.00 105.52 ? 244 LYS A CG  1 
ATOM 331  C CD  . LYS A 1 46  ? -9.804  -2.105  12.928  1.00 104.41 ? 244 LYS A CD  1 
ATOM 332  C CE  . LYS A 1 46  ? -9.164  -0.738  13.066  1.00 106.83 ? 244 LYS A CE  1 
ATOM 333  N NZ  . LYS A 1 46  ? -7.787  -0.741  12.500  1.00 98.76  ? 244 LYS A NZ  1 
ATOM 334  N N   . SER A 1 47  ? -14.765 -1.376  12.645  1.00 113.69 ? 245 SER A N   1 
ATOM 335  C CA  . SER A 1 47  ? -15.601 -0.387  11.980  1.00 94.78  ? 245 SER A CA  1 
ATOM 336  C C   . SER A 1 47  ? -14.781 0.402   10.962  1.00 86.94  ? 245 SER A C   1 
ATOM 337  O O   . SER A 1 47  ? -13.602 0.687   11.199  1.00 87.43  ? 245 SER A O   1 
ATOM 338  C CB  . SER A 1 47  ? -16.223 0.563   13.003  1.00 85.68  ? 245 SER A CB  1 
ATOM 339  O OG  . SER A 1 47  ? -17.090 -0.133  13.882  1.00 83.43  ? 245 SER A OG  1 
ATOM 340  N N   . PRO A 1 48  ? -15.368 0.763   9.825   1.00 76.58  ? 246 PRO A N   1 
ATOM 341  C CA  . PRO A 1 48  ? -14.622 1.516   8.813   1.00 73.11  ? 246 PRO A CA  1 
ATOM 342  C C   . PRO A 1 48  ? -14.284 2.917   9.298   1.00 68.76  ? 246 PRO A C   1 
ATOM 343  O O   . PRO A 1 48  ? -14.950 3.489   10.163  1.00 64.44  ? 246 PRO A O   1 
ATOM 344  C CB  . PRO A 1 48  ? -15.582 1.564   7.617   1.00 71.10  ? 246 PRO A CB  1 
ATOM 345  C CG  . PRO A 1 48  ? -16.593 0.494   7.881   1.00 72.21  ? 246 PRO A CG  1 
ATOM 346  C CD  . PRO A 1 48  ? -16.721 0.411   9.366   1.00 72.47  ? 246 PRO A CD  1 
ATOM 347  N N   . PHE A 1 49  ? -13.221 3.468   8.718   1.00 73.59  ? 247 PHE A N   1 
ATOM 348  C CA  . PHE A 1 49  ? -12.783 4.824   9.026   1.00 72.75  ? 247 PHE A CA  1 
ATOM 349  C C   . PHE A 1 49  ? -13.524 5.786   8.105   1.00 75.00  ? 247 PHE A C   1 
ATOM 350  O O   . PHE A 1 49  ? -13.339 5.755   6.884   1.00 67.86  ? 247 PHE A O   1 
ATOM 351  C CB  . PHE A 1 49  ? -11.271 4.952   8.867   1.00 77.44  ? 247 PHE A CB  1 
ATOM 352  C CG  . PHE A 1 49  ? -10.686 6.142   9.572   1.00 98.74  ? 247 PHE A CG  1 
ATOM 353  C CD1 . PHE A 1 49  ? -10.244 6.039   10.881  1.00 105.04 ? 247 PHE A CD1 1 
ATOM 354  C CD2 . PHE A 1 49  ? -10.577 7.363   8.927   1.00 92.96  ? 247 PHE A CD2 1 
ATOM 355  C CE1 . PHE A 1 49  ? -9.704  7.131   11.534  1.00 92.87  ? 247 PHE A CE1 1 
ATOM 356  C CE2 . PHE A 1 49  ? -10.039 8.459   9.575   1.00 84.63  ? 247 PHE A CE2 1 
ATOM 357  C CZ  . PHE A 1 49  ? -9.601  8.343   10.880  1.00 93.51  ? 247 PHE A CZ  1 
ATOM 358  N N   . VAL A 1 50  ? -14.366 6.633   8.687   1.00 71.04  ? 248 VAL A N   1 
ATOM 359  C CA  . VAL A 1 50  ? -15.209 7.531   7.906   1.00 69.77  ? 248 VAL A CA  1 
ATOM 360  C C   . VAL A 1 50  ? -14.399 8.751   7.489   1.00 63.01  ? 248 VAL A C   1 
ATOM 361  O O   . VAL A 1 50  ? -13.727 9.381   8.315   1.00 66.82  ? 248 VAL A O   1 
ATOM 362  C CB  . VAL A 1 50  ? -16.456 7.939   8.705   1.00 58.98  ? 248 VAL A CB  1 
ATOM 363  C CG1 . VAL A 1 50  ? -17.377 8.796   7.848   1.00 56.86  ? 248 VAL A CG1 1 
ATOM 364  C CG2 . VAL A 1 50  ? -17.187 6.705   9.214   1.00 62.27  ? 248 VAL A CG2 1 
ATOM 365  N N   . ILE A 1 51  ? -14.463 9.088   6.205   1.00 50.56  ? 249 ILE A N   1 
ATOM 366  C CA  . ILE A 1 51  ? -13.815 10.272  5.655   1.00 49.93  ? 249 ILE A CA  1 
ATOM 367  C C   . ILE A 1 51  ? -14.918 11.227  5.221   1.00 54.49  ? 249 ILE A C   1 
ATOM 368  O O   . ILE A 1 51  ? -15.588 10.997  4.207   1.00 51.82  ? 249 ILE A O   1 
ATOM 369  C CB  . ILE A 1 51  ? -12.885 9.925   4.485   1.00 57.04  ? 249 ILE A CB  1 
ATOM 370  C CG1 . ILE A 1 51  ? -11.783 8.968   4.944   1.00 56.69  ? 249 ILE A CG1 1 
ATOM 371  C CG2 . ILE A 1 51  ? -12.287 11.190  3.887   1.00 47.81  ? 249 ILE A CG2 1 
ATOM 372  C CD1 . ILE A 1 51  ? -10.830 8.559   3.843   1.00 62.17  ? 249 ILE A CD1 1 
ATOM 373  N N   . TYR A 1 52  ? -15.114 12.299  5.990   1.00 55.36  ? 250 TYR A N   1 
ATOM 374  C CA  . TYR A 1 52  ? -16.182 13.249  5.723   1.00 48.35  ? 250 TYR A CA  1 
ATOM 375  C C   . TYR A 1 52  ? -15.704 14.673  5.481   1.00 51.09  ? 250 TYR A C   1 
ATOM 376  O O   . TYR A 1 52  ? -16.519 15.515  5.092   1.00 59.85  ? 250 TYR A O   1 
ATOM 377  C CB  . TYR A 1 52  ? -17.198 13.254  6.878   1.00 54.44  ? 250 TYR A CB  1 
ATOM 378  C CG  . TYR A 1 52  ? -16.634 13.711  8.205   1.00 54.80  ? 250 TYR A CG  1 
ATOM 379  C CD1 . TYR A 1 52  ? -15.952 12.829  9.034   1.00 59.52  ? 250 TYR A CD1 1 
ATOM 380  C CD2 . TYR A 1 52  ? -16.795 15.022  8.636   1.00 58.34  ? 250 TYR A CD2 1 
ATOM 381  C CE1 . TYR A 1 52  ? -15.438 13.241  10.249  1.00 56.40  ? 250 TYR A CE1 1 
ATOM 382  C CE2 . TYR A 1 52  ? -16.285 15.443  9.849   1.00 59.19  ? 250 TYR A CE2 1 
ATOM 383  C CZ  . TYR A 1 52  ? -15.608 14.549  10.651  1.00 61.33  ? 250 TYR A CZ  1 
ATOM 384  O OH  . TYR A 1 52  ? -15.099 14.964  11.860  1.00 68.16  ? 250 TYR A OH  1 
ATOM 385  N N   . ASP A 1 53  ? -14.426 14.971  5.700   1.00 52.98  ? 251 ASP A N   1 
ATOM 386  C CA  . ASP A 1 53  ? -13.886 16.296  5.418   1.00 53.06  ? 251 ASP A CA  1 
ATOM 387  C C   . ASP A 1 53  ? -12.391 16.160  5.150   1.00 56.02  ? 251 ASP A C   1 
ATOM 388  O O   . ASP A 1 53  ? -11.858 15.050  5.056   1.00 58.55  ? 251 ASP A O   1 
ATOM 389  C CB  . ASP A 1 53  ? -14.193 17.270  6.565   1.00 58.90  ? 251 ASP A CB  1 
ATOM 390  C CG  . ASP A 1 53  ? -13.658 16.793  7.903   1.00 62.44  ? 251 ASP A CG  1 
ATOM 391  O OD1 . ASP A 1 53  ? -13.140 15.660  7.977   1.00 64.58  ? 251 ASP A OD1 1 
ATOM 392  O OD2 . ASP A 1 53  ? -13.759 17.557  8.886   1.00 65.81  ? 251 ASP A OD2 1 
ATOM 393  N N   . MET A 1 54  ? -11.710 17.302  5.026   1.00 55.72  ? 252 MET A N   1 
ATOM 394  C CA  . MET A 1 54  ? -10.286 17.284  4.704   1.00 58.77  ? 252 MET A CA  1 
ATOM 395  C C   . MET A 1 54  ? -9.456  16.746  5.864   1.00 60.97  ? 252 MET A C   1 
ATOM 396  O O   . MET A 1 54  ? -8.455  16.053  5.646   1.00 65.79  ? 252 MET A O   1 
ATOM 397  C CB  . MET A 1 54  ? -9.817  18.686  4.315   1.00 52.82  ? 252 MET A CB  1 
ATOM 398  C CG  . MET A 1 54  ? -10.295 19.143  2.948   1.00 70.40  ? 252 MET A CG  1 
ATOM 399  S SD  . MET A 1 54  ? -9.656  18.106  1.618   1.00 71.32  ? 252 MET A SD  1 
ATOM 400  C CE  . MET A 1 54  ? -7.891  18.299  1.859   1.00 69.85  ? 252 MET A CE  1 
ATOM 401  N N   . ASN A 1 55  ? -9.850  17.055  7.102   1.00 58.46  ? 253 ASN A N   1 
ATOM 402  C CA  . ASN A 1 55  ? -9.092  16.577  8.254   1.00 58.98  ? 253 ASN A CA  1 
ATOM 403  C C   . ASN A 1 55  ? -9.198  15.064  8.401   1.00 57.82  ? 253 ASN A C   1 
ATOM 404  O O   . ASN A 1 55  ? -8.199  14.392  8.683   1.00 74.20  ? 253 ASN A O   1 
ATOM 405  C CB  . ASN A 1 55  ? -9.568  17.276  9.527   1.00 57.84  ? 253 ASN A CB  1 
ATOM 406  C CG  . ASN A 1 55  ? -9.023  18.684  9.656   1.00 63.04  ? 253 ASN A CG  1 
ATOM 407  O OD1 . ASN A 1 55  ? -9.630  19.643  9.180   1.00 83.93  ? 253 ASN A OD1 1 
ATOM 408  N ND2 . ASN A 1 55  ? -7.870  18.814  10.302  1.00 68.00  ? 253 ASN A ND2 1 
ATOM 409  N N   . SER A 1 56  ? -10.399 14.509  8.217   1.00 59.26  ? 254 SER A N   1 
ATOM 410  C CA  . SER A 1 56  ? -10.557 13.060  8.257   1.00 60.14  ? 254 SER A CA  1 
ATOM 411  C C   . SER A 1 56  ? -9.843  12.374  7.101   1.00 60.64  ? 254 SER A C   1 
ATOM 412  O O   . SER A 1 56  ? -9.503  11.191  7.212   1.00 72.73  ? 254 SER A O   1 
ATOM 413  C CB  . SER A 1 56  ? -12.041 12.689  8.248   1.00 61.28  ? 254 SER A CB  1 
ATOM 414  O OG  . SER A 1 56  ? -12.688 13.207  7.099   1.00 62.36  ? 254 SER A OG  1 
ATOM 415  N N   . LEU A 1 57  ? -9.608  13.086  5.997   1.00 60.05  ? 255 LEU A N   1 
ATOM 416  C CA  . LEU A 1 57  ? -8.841  12.511  4.897   1.00 60.90  ? 255 LEU A CA  1 
ATOM 417  C C   . LEU A 1 57  ? -7.373  12.348  5.269   1.00 71.17  ? 255 LEU A C   1 
ATOM 418  O O   . LEU A 1 57  ? -6.721  11.395  4.829   1.00 79.05  ? 255 LEU A O   1 
ATOM 419  C CB  . LEU A 1 57  ? -8.983  13.380  3.648   1.00 50.59  ? 255 LEU A CB  1 
ATOM 420  C CG  . LEU A 1 57  ? -8.203  12.947  2.402   1.00 55.52  ? 255 LEU A CG  1 
ATOM 421  C CD1 . LEU A 1 57  ? -8.603  11.545  1.967   1.00 46.74  ? 255 LEU A CD1 1 
ATOM 422  C CD2 . LEU A 1 57  ? -8.406  13.940  1.266   1.00 40.81  ? 255 LEU A CD2 1 
ATOM 423  N N   . MET A 1 58  ? -6.836  13.262  6.077   1.00 75.81  ? 256 MET A N   1 
ATOM 424  C CA  . MET A 1 58  ? -5.411  13.210  6.390   1.00 80.91  ? 256 MET A CA  1 
ATOM 425  C C   . MET A 1 58  ? -5.102  12.096  7.385   1.00 83.42  ? 256 MET A C   1 
ATOM 426  O O   . MET A 1 58  ? -4.156  11.325  7.191   1.00 88.81  ? 256 MET A O   1 
ATOM 427  C CB  . MET A 1 58  ? -4.945  14.561  6.929   1.00 79.82  ? 256 MET A CB  1 
ATOM 428  C CG  . MET A 1 58  ? -5.143  15.707  5.947   1.00 70.18  ? 256 MET A CG  1 
ATOM 429  S SD  . MET A 1 58  ? -4.410  15.366  4.338   1.00 113.70 ? 256 MET A SD  1 
ATOM 430  C CE  . MET A 1 58  ? -4.834  16.873  3.474   1.00 82.14  ? 256 MET A CE  1 
ATOM 431  N N   . MET A 1 59  ? -5.885  11.997  8.459   1.00 82.32  ? 257 MET A N   1 
ATOM 432  C CA  . MET A 1 59  ? -5.778  10.906  9.420   1.00 86.81  ? 257 MET A CA  1 
ATOM 433  C C   . MET A 1 59  ? -6.324  9.587   8.877   1.00 93.30  ? 257 MET A C   1 
ATOM 434  O O   . MET A 1 59  ? -6.462  8.618   9.633   1.00 103.54 ? 257 MET A O   1 
ATOM 435  C CB  . MET A 1 59  ? -6.471  11.292  10.732  1.00 97.05  ? 257 MET A CB  1 
ATOM 436  C CG  . MET A 1 59  ? -5.622  12.218  11.611  1.00 108.15 ? 257 MET A CG  1 
ATOM 437  S SD  . MET A 1 59  ? -3.966  11.542  11.858  1.00 131.50 ? 257 MET A SD  1 
ATOM 438  C CE  . MET A 1 59  ? -2.962  12.854  11.167  1.00 114.60 ? 257 MET A CE  1 
ATOM 439  N N   . GLY A 1 60  ? -6.644  9.526   7.587   1.00 88.22  ? 258 GLY A N   1 
ATOM 440  C CA  . GLY A 1 60  ? -6.800  8.261   6.895   1.00 85.42  ? 258 GLY A CA  1 
ATOM 441  C C   . GLY A 1 60  ? -5.853  8.207   5.714   1.00 91.13  ? 258 GLY A C   1 
ATOM 442  O O   . GLY A 1 60  ? -5.761  7.190   5.023   1.00 101.69 ? 258 GLY A O   1 
ATOM 443  N N   . GLU A 1 61  ? -5.142  9.314   5.495   1.00 92.80  ? 259 GLU A N   1 
ATOM 444  C CA  . GLU A 1 61  ? -4.157  9.494   4.423   1.00 91.24  ? 259 GLU A CA  1 
ATOM 445  C C   . GLU A 1 61  ? -4.764  9.285   3.043   1.00 89.76  ? 259 GLU A C   1 
ATOM 446  O O   . GLU A 1 61  ? -4.612  10.129  2.164   1.00 83.25  ? 259 GLU A O   1 
ATOM 447  C CB  . GLU A 1 61  ? -2.958  8.561   4.614   1.00 100.49 ? 259 GLU A CB  1 
ATOM 448  C CG  . GLU A 1 61  ? -2.395  8.539   6.027   1.00 99.03  ? 259 GLU A CG  1 
ATOM 449  C CD  . GLU A 1 61  ? -2.493  7.162   6.649   1.00 106.50 ? 259 GLU A CD  1 
ATOM 450  O OE1 . GLU A 1 61  ? -2.855  7.068   7.839   1.00 99.64  ? 259 GLU A OE1 1 
ATOM 451  O OE2 . GLU A 1 61  ? -2.225  6.171   5.938   1.00 106.78 ? 259 GLU A OE2 1 
ATOM 452  N N   . SER A 1 91  ? -9.833  -0.098  -9.747  1.00 100.70 ? 289 SER A N   1 
ATOM 453  C CA  . SER A 1 91  ? -10.492 -0.527  -10.975 1.00 97.92  ? 289 SER A CA  1 
ATOM 454  C C   . SER A 1 91  ? -9.763  -1.711  -11.601 1.00 101.96 ? 289 SER A C   1 
ATOM 455  O O   . SER A 1 91  ? -10.391 -2.626  -12.132 1.00 97.67  ? 289 SER A O   1 
ATOM 456  C CB  . SER A 1 91  ? -10.574 0.630   -11.973 1.00 90.17  ? 289 SER A CB  1 
ATOM 457  O OG  . SER A 1 91  ? -11.232 0.232   -13.163 1.00 92.62  ? 289 SER A OG  1 
ATOM 458  N N   . VAL A 1 92  ? -8.430  -1.684  -11.534 1.00 101.27 ? 290 VAL A N   1 
ATOM 459  C CA  . VAL A 1 92  ? -7.632  -2.771  -12.095 1.00 94.55  ? 290 VAL A CA  1 
ATOM 460  C C   . VAL A 1 92  ? -7.889  -4.069  -11.339 1.00 93.62  ? 290 VAL A C   1 
ATOM 461  O O   . VAL A 1 92  ? -7.912  -5.155  -11.931 1.00 89.90  ? 290 VAL A O   1 
ATOM 462  C CB  . VAL A 1 92  ? -6.140  -2.391  -12.086 1.00 90.31  ? 290 VAL A CB  1 
ATOM 463  C CG1 . VAL A 1 92  ? -5.294  -3.520  -12.657 1.00 89.85  ? 290 VAL A CG1 1 
ATOM 464  C CG2 . VAL A 1 92  ? -5.917  -1.105  -12.867 1.00 90.11  ? 290 VAL A CG2 1 
ATOM 465  N N   . GLU A 1 93  ? -8.093  -3.979  -10.023 1.00 94.41  ? 291 GLU A N   1 
ATOM 466  C CA  . GLU A 1 93  ? -8.380  -5.173  -9.234  1.00 96.06  ? 291 GLU A CA  1 
ATOM 467  C C   . GLU A 1 93  ? -9.727  -5.776  -9.612  1.00 87.24  ? 291 GLU A C   1 
ATOM 468  O O   . GLU A 1 93  ? -9.873  -7.003  -9.660  1.00 84.51  ? 291 GLU A O   1 
ATOM 469  C CB  . GLU A 1 93  ? -8.341  -4.834  -7.743  1.00 105.81 ? 291 GLU A CB  1 
ATOM 470  C CG  . GLU A 1 93  ? -8.783  -5.966  -6.827  1.00 113.42 ? 291 GLU A CG  1 
ATOM 471  C CD  . GLU A 1 93  ? -7.836  -7.150  -6.854  1.00 115.06 ? 291 GLU A CD  1 
ATOM 472  O OE1 . GLU A 1 93  ? -6.639  -6.952  -7.148  1.00 119.60 ? 291 GLU A OE1 1 
ATOM 473  O OE2 . GLU A 1 93  ? -8.291  -8.281  -6.581  1.00 106.80 ? 291 GLU A OE2 1 
ATOM 474  N N   . ALA A 1 94  ? -10.722 -4.930  -9.892  1.00 78.37  ? 292 ALA A N   1 
ATOM 475  C CA  . ALA A 1 94  ? -12.052 -5.435  -10.216 1.00 78.85  ? 292 ALA A CA  1 
ATOM 476  C C   . ALA A 1 94  ? -12.094 -6.087  -11.592 1.00 77.29  ? 292 ALA A C   1 
ATOM 477  O O   . ALA A 1 94  ? -12.876 -7.020  -11.806 1.00 73.21  ? 292 ALA A O   1 
ATOM 478  C CB  . ALA A 1 94  ? -13.078 -4.304  -10.134 1.00 74.69  ? 292 ALA A CB  1 
ATOM 479  N N   . VAL A 1 95  ? -11.271 -5.615  -12.532 1.00 79.40  ? 293 VAL A N   1 
ATOM 480  C CA  . VAL A 1 95  ? -11.256 -6.195  -13.873 1.00 75.37  ? 293 VAL A CA  1 
ATOM 481  C C   . VAL A 1 95  ? -10.849 -7.662  -13.815 1.00 74.04  ? 293 VAL A C   1 
ATOM 482  O O   . VAL A 1 95  ? -11.387 -8.503  -14.546 1.00 71.98  ? 293 VAL A O   1 
ATOM 483  C CB  . VAL A 1 95  ? -10.326 -5.385  -14.796 1.00 74.65  ? 293 VAL A CB  1 
ATOM 484  C CG1 . VAL A 1 95  ? -10.174 -6.072  -16.144 1.00 73.25  ? 293 VAL A CG1 1 
ATOM 485  C CG2 . VAL A 1 95  ? -10.858 -3.973  -14.978 1.00 74.96  ? 293 VAL A CG2 1 
ATOM 486  N N   . GLN A 1 96  ? -9.904  -7.996  -12.935 1.00 83.88  ? 294 GLN A N   1 
ATOM 487  C CA  . GLN A 1 96  ? -9.446  -9.376  -12.826 1.00 79.97  ? 294 GLN A CA  1 
ATOM 488  C C   . GLN A 1 96  ? -10.492 -10.267 -12.168 1.00 71.39  ? 294 GLN A C   1 
ATOM 489  O O   . GLN A 1 96  ? -10.611 -11.445 -12.523 1.00 68.80  ? 294 GLN A O   1 
ATOM 490  C CB  . GLN A 1 96  ? -8.131  -9.425  -12.048 1.00 94.30  ? 294 GLN A CB  1 
ATOM 491  C CG  . GLN A 1 96  ? -7.103  -8.414  -12.534 1.00 95.58  ? 294 GLN A CG  1 
ATOM 492  C CD  . GLN A 1 96  ? -5.866  -8.367  -11.660 1.00 110.36 ? 294 GLN A CD  1 
ATOM 493  O OE1 . GLN A 1 96  ? -5.304  -7.299  -11.419 1.00 107.83 ? 294 GLN A OE1 1 
ATOM 494  N NE2 . GLN A 1 96  ? -5.431  -9.529  -11.186 1.00 125.18 ? 294 GLN A NE2 1 
ATOM 495  N N   . GLU A 1 97  ? -11.257 -9.728  -11.215 1.00 80.96  ? 295 GLU A N   1 
ATOM 496  C CA  . GLU A 1 97  ? -12.289 -10.522 -10.557 1.00 72.83  ? 295 GLU A CA  1 
ATOM 497  C C   . GLU A 1 97  ? -13.462 -10.790 -11.492 1.00 72.89  ? 295 GLU A C   1 
ATOM 498  O O   . GLU A 1 97  ? -14.035 -11.886 -11.481 1.00 61.15  ? 295 GLU A O   1 
ATOM 499  C CB  . GLU A 1 97  ? -12.769 -9.812  -9.291  1.00 71.44  ? 295 GLU A CB  1 
ATOM 500  C CG  . GLU A 1 97  ? -11.662 -9.459  -8.314  1.00 89.71  ? 295 GLU A CG  1 
ATOM 501  C CD  . GLU A 1 97  ? -12.159 -8.614  -7.157  1.00 90.31  ? 295 GLU A CD  1 
ATOM 502  O OE1 . GLU A 1 97  ? -13.374 -8.330  -7.106  1.00 90.15  ? 295 GLU A OE1 1 
ATOM 503  O OE2 . GLU A 1 97  ? -11.334 -8.231  -6.301  1.00 93.43  ? 295 GLU A OE2 1 
ATOM 504  N N   . ILE A 1 98  ? -13.836 -9.799  -12.303 1.00 63.77  ? 296 ILE A N   1 
ATOM 505  C CA  . ILE A 1 98  ? -14.963 -9.964  -13.216 1.00 57.68  ? 296 ILE A CA  1 
ATOM 506  C C   . ILE A 1 98  ? -14.631 -10.985 -14.298 1.00 69.62  ? 296 ILE A C   1 
ATOM 507  O O   . ILE A 1 98  ? -15.486 -11.783 -14.701 1.00 59.43  ? 296 ILE A O   1 
ATOM 508  C CB  . ILE A 1 98  ? -15.360 -8.602  -13.813 1.00 63.87  ? 296 ILE A CB  1 
ATOM 509  C CG1 . ILE A 1 98  ? -15.834 -7.661  -12.705 1.00 55.60  ? 296 ILE A CG1 1 
ATOM 510  C CG2 . ILE A 1 98  ? -16.441 -8.769  -14.871 1.00 48.83  ? 296 ILE A CG2 1 
ATOM 511  C CD1 . ILE A 1 98  ? -15.934 -6.217  -13.132 1.00 59.08  ? 296 ILE A CD1 1 
ATOM 512  N N   . THR A 1 99  ? -13.386 -10.981 -14.781 1.00 71.68  ? 297 THR A N   1 
ATOM 513  C CA  . THR A 1 99  ? -12.977 -11.970 -15.773 1.00 69.59  ? 297 THR A CA  1 
ATOM 514  C C   . THR A 1 99  ? -13.026 -13.379 -15.194 1.00 63.41  ? 297 THR A C   1 
ATOM 515  O O   . THR A 1 99  ? -13.406 -14.330 -15.888 1.00 68.36  ? 297 THR A O   1 
ATOM 516  C CB  . THR A 1 99  ? -11.573 -11.649 -16.290 1.00 77.33  ? 297 THR A CB  1 
ATOM 517  O OG1 . THR A 1 99  ? -11.554 -10.320 -16.827 1.00 72.66  ? 297 THR A OG1 1 
ATOM 518  C CG2 . THR A 1 99  ? -11.165 -12.631 -17.379 1.00 76.80  ? 297 THR A CG2 1 
ATOM 519  N N   . GLU A 1 100 ? -12.656 -13.531 -13.920 1.00 70.20  ? 298 GLU A N   1 
ATOM 520  C CA  . GLU A 1 100 ? -12.745 -14.837 -13.275 1.00 68.06  ? 298 GLU A CA  1 
ATOM 521  C C   . GLU A 1 100 ? -14.190 -15.316 -13.199 1.00 71.92  ? 298 GLU A C   1 
ATOM 522  O O   . GLU A 1 100 ? -14.468 -16.505 -13.393 1.00 72.20  ? 298 GLU A O   1 
ATOM 523  C CB  . GLU A 1 100 ? -12.125 -14.775 -11.878 1.00 76.17  ? 298 GLU A CB  1 
ATOM 524  C CG  . GLU A 1 100 ? -10.614 -14.611 -11.876 1.00 82.83  ? 298 GLU A CG  1 
ATOM 525  C CD  . GLU A 1 100 ? -9.895  -15.843 -12.391 1.00 95.07  ? 298 GLU A CD  1 
ATOM 526  O OE1 . GLU A 1 100 ? -10.376 -16.965 -12.128 1.00 92.38  ? 298 GLU A OE1 1 
ATOM 527  O OE2 . GLU A 1 100 ? -8.853  -15.688 -13.062 1.00 95.40  ? 298 GLU A OE2 1 
ATOM 528  N N   . TYR A 1 101 ? -15.124 -14.402 -12.920 1.00 65.93  ? 299 TYR A N   1 
ATOM 529  C CA  . TYR A 1 101 ? -16.531 -14.784 -12.860 1.00 59.34  ? 299 TYR A CA  1 
ATOM 530  C C   . TYR A 1 101 ? -17.090 -15.087 -14.244 1.00 57.81  ? 299 TYR A C   1 
ATOM 531  O O   . TYR A 1 101 ? -17.942 -15.972 -14.386 1.00 51.02  ? 299 TYR A O   1 
ATOM 532  C CB  . TYR A 1 101 ? -17.349 -13.681 -12.185 1.00 58.13  ? 299 TYR A CB  1 
ATOM 533  C CG  . TYR A 1 101 ? -18.834 -13.965 -12.148 1.00 56.33  ? 299 TYR A CG  1 
ATOM 534  C CD1 . TYR A 1 101 ? -19.355 -14.918 -11.284 1.00 47.87  ? 299 TYR A CD1 1 
ATOM 535  C CD2 . TYR A 1 101 ? -19.714 -13.278 -12.975 1.00 50.32  ? 299 TYR A CD2 1 
ATOM 536  C CE1 . TYR A 1 101 ? -20.710 -15.183 -11.247 1.00 47.17  ? 299 TYR A CE1 1 
ATOM 537  C CE2 . TYR A 1 101 ? -21.072 -13.535 -12.944 1.00 50.79  ? 299 TYR A CE2 1 
ATOM 538  C CZ  . TYR A 1 101 ? -21.565 -14.488 -12.077 1.00 46.18  ? 299 TYR A CZ  1 
ATOM 539  O OH  . TYR A 1 101 ? -22.916 -14.750 -12.040 1.00 43.81  ? 299 TYR A OH  1 
ATOM 540  N N   . ALA A 1 102 ? -16.625 -14.372 -15.272 1.00 56.19  ? 300 ALA A N   1 
ATOM 541  C CA  . ALA A 1 102 ? -17.105 -14.633 -16.625 1.00 60.32  ? 300 ALA A CA  1 
ATOM 542  C C   . ALA A 1 102 ? -16.679 -16.010 -17.116 1.00 59.96  ? 300 ALA A C   1 
ATOM 543  O O   . ALA A 1 102 ? -17.414 -16.649 -17.877 1.00 64.09  ? 300 ALA A O   1 
ATOM 544  C CB  . ALA A 1 102 ? -16.605 -13.550 -17.580 1.00 51.60  ? 300 ALA A CB  1 
ATOM 545  N N   . LYS A 1 103 ? -15.507 -16.483 -16.690 1.00 64.47  ? 301 LYS A N   1 
ATOM 546  C CA  . LYS A 1 103 ? -15.043 -17.808 -17.085 1.00 61.71  ? 301 LYS A CA  1 
ATOM 547  C C   . LYS A 1 103 ? -15.901 -18.920 -16.498 1.00 57.31  ? 301 LYS A C   1 
ATOM 548  O O   . LYS A 1 103 ? -15.865 -20.046 -17.006 1.00 70.72  ? 301 LYS A O   1 
ATOM 549  C CB  . LYS A 1 103 ? -13.583 -17.996 -16.668 1.00 64.73  ? 301 LYS A CB  1 
ATOM 550  C CG  . LYS A 1 103 ? -12.620 -17.049 -17.363 1.00 77.03  ? 301 LYS A CG  1 
ATOM 551  C CD  . LYS A 1 103 ? -11.269 -17.010 -16.667 1.00 80.36  ? 301 LYS A CD  1 
ATOM 552  C CE  . LYS A 1 103 ? -10.597 -18.372 -16.675 1.00 84.40  ? 301 LYS A CE  1 
ATOM 553  N NZ  . LYS A 1 103 ? -9.266  -18.328 -16.010 1.00 81.48  ? 301 LYS A NZ  1 
ATOM 554  N N   . SER A 1 104 ? -16.665 -18.632 -15.447 1.00 59.88  ? 302 SER A N   1 
ATOM 555  C CA  . SER A 1 104 ? -17.553 -19.613 -14.841 1.00 58.89  ? 302 SER A CA  1 
ATOM 556  C C   . SER A 1 104 ? -18.937 -19.635 -15.472 1.00 54.73  ? 302 SER A C   1 
ATOM 557  O O   . SER A 1 104 ? -19.718 -20.547 -15.178 1.00 59.92  ? 302 SER A O   1 
ATOM 558  C CB  . SER A 1 104 ? -17.683 -19.348 -13.339 1.00 64.75  ? 302 SER A CB  1 
ATOM 559  O OG  . SER A 1 104 ? -18.095 -18.014 -13.096 1.00 69.28  ? 302 SER A OG  1 
ATOM 560  N N   . ILE A 1 105 ? -19.263 -18.659 -16.309 1.00 56.62  ? 303 ILE A N   1 
ATOM 561  C CA  . ILE A 1 105 ? -20.559 -18.666 -16.995 1.00 53.76  ? 303 ILE A CA  1 
ATOM 562  C C   . ILE A 1 105 ? -20.579 -19.803 -18.009 1.00 59.88  ? 303 ILE A C   1 
ATOM 563  O O   . ILE A 1 105 ? -19.670 -19.893 -18.854 1.00 58.15  ? 303 ILE A O   1 
ATOM 564  C CB  . ILE A 1 105 ? -20.811 -17.319 -17.672 1.00 56.53  ? 303 ILE A CB  1 
ATOM 565  C CG1 . ILE A 1 105 ? -20.795 -16.194 -16.638 1.00 46.29  ? 303 ILE A CG1 1 
ATOM 566  C CG2 . ILE A 1 105 ? -22.137 -17.337 -18.430 1.00 53.61  ? 303 ILE A CG2 1 
ATOM 567  C CD1 . ILE A 1 105 ? -21.017 -14.816 -17.226 1.00 43.46  ? 303 ILE A CD1 1 
ATOM 568  N N   . PRO A 1 106 ? -21.573 -20.690 -17.971 1.00 58.16  ? 304 PRO A N   1 
ATOM 569  C CA  . PRO A 1 106 ? -21.574 -21.843 -18.886 1.00 59.41  ? 304 PRO A CA  1 
ATOM 570  C C   . PRO A 1 106 ? -21.647 -21.403 -20.340 1.00 60.88  ? 304 PRO A C   1 
ATOM 571  O O   . PRO A 1 106 ? -22.596 -20.739 -20.760 1.00 59.47  ? 304 PRO A O   1 
ATOM 572  C CB  . PRO A 1 106 ? -22.826 -22.625 -18.470 1.00 50.92  ? 304 PRO A CB  1 
ATOM 573  C CG  . PRO A 1 106 ? -23.103 -22.183 -17.070 1.00 53.59  ? 304 PRO A CG  1 
ATOM 574  C CD  . PRO A 1 106 ? -22.688 -20.746 -17.013 1.00 50.90  ? 304 PRO A CD  1 
ATOM 575  N N   . GLY A 1 107 ? -20.625 -21.778 -21.108 1.00 61.65  ? 305 GLY A N   1 
ATOM 576  C CA  . GLY A 1 107 ? -20.550 -21.464 -22.517 1.00 54.04  ? 305 GLY A CA  1 
ATOM 577  C C   . GLY A 1 107 ? -19.688 -20.269 -22.860 1.00 67.45  ? 305 GLY A C   1 
ATOM 578  O O   . GLY A 1 107 ? -19.406 -20.051 -24.045 1.00 72.73  ? 305 GLY A O   1 
ATOM 579  N N   . PHE A 1 108 ? -19.258 -19.491 -21.863 1.00 52.16  ? 306 PHE A N   1 
ATOM 580  C CA  . PHE A 1 108 ? -18.461 -18.302 -22.147 1.00 61.98  ? 306 PHE A CA  1 
ATOM 581  C C   . PHE A 1 108 ? -17.054 -18.672 -22.600 1.00 66.06  ? 306 PHE A C   1 
ATOM 582  O O   . PHE A 1 108 ? -16.497 -18.030 -23.498 1.00 66.18  ? 306 PHE A O   1 
ATOM 583  C CB  . PHE A 1 108 ? -18.409 -17.399 -20.914 1.00 53.11  ? 306 PHE A CB  1 
ATOM 584  C CG  . PHE A 1 108 ? -17.664 -16.111 -21.134 1.00 52.07  ? 306 PHE A CG  1 
ATOM 585  C CD1 . PHE A 1 108 ? -18.302 -15.012 -21.684 1.00 52.48  ? 306 PHE A CD1 1 
ATOM 586  C CD2 . PHE A 1 108 ? -16.328 -15.998 -20.783 1.00 60.73  ? 306 PHE A CD2 1 
ATOM 587  C CE1 . PHE A 1 108 ? -17.621 -13.826 -21.886 1.00 49.91  ? 306 PHE A CE1 1 
ATOM 588  C CE2 . PHE A 1 108 ? -15.642 -14.814 -20.983 1.00 52.98  ? 306 PHE A CE2 1 
ATOM 589  C CZ  . PHE A 1 108 ? -16.290 -13.728 -21.534 1.00 58.62  ? 306 PHE A CZ  1 
ATOM 590  N N   . VAL A 1 109 ? -16.460 -19.701 -21.989 1.00 73.24  ? 307 VAL A N   1 
ATOM 591  C CA  . VAL A 1 109 ? -15.113 -20.108 -22.367 1.00 69.72  ? 307 VAL A CA  1 
ATOM 592  C C   . VAL A 1 109 ? -15.092 -20.811 -23.717 1.00 71.59  ? 307 VAL A C   1 
ATOM 593  O O   . VAL A 1 109 ? -14.030 -20.911 -24.342 1.00 64.75  ? 307 VAL A O   1 
ATOM 594  C CB  . VAL A 1 109 ? -14.496 -21.009 -21.280 1.00 70.77  ? 307 VAL A CB  1 
ATOM 595  C CG1 . VAL A 1 109 ? -14.401 -20.258 -19.962 1.00 68.35  ? 307 VAL A CG1 1 
ATOM 596  C CG2 . VAL A 1 109 ? -15.313 -22.282 -21.118 1.00 58.85  ? 307 VAL A CG2 1 
ATOM 597  N N   . ASN A 1 110 ? -16.240 -21.300 -24.188 1.00 73.88  ? 308 ASN A N   1 
ATOM 598  C CA  . ASN A 1 110 ? -16.308 -21.977 -25.475 1.00 67.25  ? 308 ASN A CA  1 
ATOM 599  C C   . ASN A 1 110 ? -16.480 -21.017 -26.644 1.00 71.18  ? 308 ASN A C   1 
ATOM 600  O O   . ASN A 1 110 ? -16.366 -21.446 -27.798 1.00 77.61  ? 308 ASN A O   1 
ATOM 601  C CB  . ASN A 1 110 ? -17.452 -22.994 -25.472 1.00 66.60  ? 308 ASN A CB  1 
ATOM 602  C CG  . ASN A 1 110 ? -17.266 -24.075 -24.425 1.00 78.04  ? 308 ASN A CG  1 
ATOM 603  O OD1 . ASN A 1 110 ? -16.150 -24.530 -24.178 1.00 79.85  ? 308 ASN A OD1 1 
ATOM 604  N ND2 . ASN A 1 110 ? -18.362 -24.486 -23.798 1.00 78.93  ? 308 ASN A ND2 1 
ATOM 605  N N   . LEU A 1 111 ? -16.749 -19.741 -26.381 1.00 70.82  ? 309 LEU A N   1 
ATOM 606  C CA  . LEU A 1 111 ? -16.868 -18.763 -27.448 1.00 68.17  ? 309 LEU A CA  1 
ATOM 607  C C   . LEU A 1 111 ? -15.498 -18.478 -28.062 1.00 80.12  ? 309 LEU A C   1 
ATOM 608  O O   . LEU A 1 111 ? -14.457 -18.928 -27.573 1.00 78.26  ? 309 LEU A O   1 
ATOM 609  C CB  . LEU A 1 111 ? -17.487 -17.467 -26.923 1.00 66.45  ? 309 LEU A CB  1 
ATOM 610  C CG  . LEU A 1 111 ? -18.841 -17.565 -26.218 1.00 68.39  ? 309 LEU A CG  1 
ATOM 611  C CD1 . LEU A 1 111 ? -19.264 -16.203 -25.690 1.00 62.11  ? 309 LEU A CD1 1 
ATOM 612  C CD2 . LEU A 1 111 ? -19.897 -18.133 -27.153 1.00 56.90  ? 309 LEU A CD2 1 
ATOM 613  N N   . ASP A 1 112 ? -15.509 -17.720 -29.156 1.00 75.50  ? 310 ASP A N   1 
ATOM 614  C CA  . ASP A 1 112 ? -14.261 -17.267 -29.756 1.00 73.00  ? 310 ASP A CA  1 
ATOM 615  C C   . ASP A 1 112 ? -13.509 -16.390 -28.764 1.00 72.80  ? 310 ASP A C   1 
ATOM 616  O O   . ASP A 1 112 ? -14.098 -15.521 -28.115 1.00 72.02  ? 310 ASP A O   1 
ATOM 617  C CB  . ASP A 1 112 ? -14.541 -16.504 -31.052 1.00 68.96  ? 310 ASP A CB  1 
ATOM 618  C CG  . ASP A 1 112 ? -13.275 -16.170 -31.825 1.00 75.34  ? 310 ASP A CG  1 
ATOM 619  O OD1 . ASP A 1 112 ? -12.432 -15.409 -31.305 1.00 80.32  ? 310 ASP A OD1 1 
ATOM 620  O OD2 . ASP A 1 112 ? -13.120 -16.676 -32.956 1.00 83.06  ? 310 ASP A OD2 1 
ATOM 621  N N   . LEU A 1 113 ? -12.200 -16.628 -28.644 1.00 72.26  ? 311 LEU A N   1 
ATOM 622  C CA  . LEU A 1 113 ? -11.409 -15.922 -27.641 1.00 73.48  ? 311 LEU A CA  1 
ATOM 623  C C   . LEU A 1 113 ? -11.407 -14.418 -27.878 1.00 83.99  ? 311 LEU A C   1 
ATOM 624  O O   . LEU A 1 113 ? -11.319 -13.641 -26.920 1.00 80.34  ? 311 LEU A O   1 
ATOM 625  C CB  . LEU A 1 113 ? -9.979  -16.463 -27.624 1.00 77.24  ? 311 LEU A CB  1 
ATOM 626  C CG  . LEU A 1 113 ? -9.078  -15.969 -26.491 1.00 83.23  ? 311 LEU A CG  1 
ATOM 627  C CD1 . LEU A 1 113 ? -9.685  -16.303 -25.137 1.00 70.79  ? 311 LEU A CD1 1 
ATOM 628  C CD2 . LEU A 1 113 ? -7.682  -16.560 -26.617 1.00 80.71  ? 311 LEU A CD2 1 
ATOM 629  N N   . ASN A 1 114 ? -11.511 -13.986 -29.137 1.00 79.57  ? 312 ASN A N   1 
ATOM 630  C CA  . ASN A 1 114 ? -11.570 -12.555 -29.419 1.00 79.23  ? 312 ASN A CA  1 
ATOM 631  C C   . ASN A 1 114 ? -12.880 -11.949 -28.933 1.00 70.68  ? 312 ASN A C   1 
ATOM 632  O O   . ASN A 1 114 ? -12.901 -10.814 -28.444 1.00 73.72  ? 312 ASN A O   1 
ATOM 633  C CB  . ASN A 1 114 ? -11.385 -12.305 -30.915 1.00 82.31  ? 312 ASN A CB  1 
ATOM 634  C CG  . ASN A 1 114 ? -10.021 -12.736 -31.414 1.00 89.62  ? 312 ASN A CG  1 
ATOM 635  O OD1 . ASN A 1 114 ? -9.049  -12.756 -30.659 1.00 83.07  ? 312 ASN A OD1 1 
ATOM 636  N ND2 . ASN A 1 114 ? -9.941  -13.081 -32.693 1.00 93.45  ? 312 ASN A ND2 1 
ATOM 637  N N   . ASP A 1 115 ? -13.985 -12.690 -29.060 1.00 66.92  ? 313 ASP A N   1 
ATOM 638  C CA  . ASP A 1 115 ? -15.266 -12.182 -28.583 1.00 76.51  ? 313 ASP A CA  1 
ATOM 639  C C   . ASP A 1 115 ? -15.333 -12.161 -27.062 1.00 69.43  ? 313 ASP A C   1 
ATOM 640  O O   . ASP A 1 115 ? -15.991 -11.287 -26.487 1.00 61.72  ? 313 ASP A O   1 
ATOM 641  C CB  . ASP A 1 115 ? -16.413 -13.015 -29.156 1.00 66.94  ? 313 ASP A CB  1 
ATOM 642  C CG  . ASP A 1 115 ? -16.623 -12.773 -30.637 1.00 75.47  ? 313 ASP A CG  1 
ATOM 643  O OD1 . ASP A 1 115 ? -16.189 -11.712 -31.134 1.00 69.08  ? 313 ASP A OD1 1 
ATOM 644  O OD2 . ASP A 1 115 ? -17.225 -13.640 -31.304 1.00 65.54  ? 313 ASP A OD2 1 
ATOM 645  N N   . GLN A 1 116 ? -14.667 -13.109 -26.396 1.00 57.75  ? 314 GLN A N   1 
ATOM 646  C CA  . GLN A 1 116 ? -14.603 -13.082 -24.939 1.00 67.87  ? 314 GLN A CA  1 
ATOM 647  C C   . GLN A 1 116 ? -13.954 -11.796 -24.445 1.00 71.96  ? 314 GLN A C   1 
ATOM 648  O O   . GLN A 1 116 ? -14.400 -11.204 -23.456 1.00 69.10  ? 314 GLN A O   1 
ATOM 649  C CB  . GLN A 1 116 ? -13.834 -14.296 -24.420 1.00 59.68  ? 314 GLN A CB  1 
ATOM 650  C CG  . GLN A 1 116 ? -14.408 -15.636 -24.841 1.00 59.30  ? 314 GLN A CG  1 
ATOM 651  C CD  . GLN A 1 116 ? -13.586 -16.801 -24.326 1.00 65.01  ? 314 GLN A CD  1 
ATOM 652  O OE1 . GLN A 1 116 ? -12.671 -16.622 -23.521 1.00 72.85  ? 314 GLN A OE1 1 
ATOM 653  N NE2 . GLN A 1 116 ? -13.905 -18.003 -24.790 1.00 77.48  ? 314 GLN A NE2 1 
ATOM 654  N N   . VAL A 1 117 ? -12.899 -11.349 -25.127 1.00 67.65  ? 315 VAL A N   1 
ATOM 655  C CA  . VAL A 1 117 ? -12.241 -10.104 -24.746 1.00 76.39  ? 315 VAL A CA  1 
ATOM 656  C C   . VAL A 1 117 ? -13.119 -8.910  -25.094 1.00 73.77  ? 315 VAL A C   1 
ATOM 657  O O   . VAL A 1 117 ? -13.146 -7.910  -24.368 1.00 79.53  ? 315 VAL A O   1 
ATOM 658  C CB  . VAL A 1 117 ? -10.859 -10.011 -25.418 1.00 72.19  ? 315 VAL A CB  1 
ATOM 659  C CG1 . VAL A 1 117 ? -10.105 -8.786  -24.925 1.00 80.01  ? 315 VAL A CG1 1 
ATOM 660  C CG2 . VAL A 1 117 ? -10.065 -11.277 -25.153 1.00 73.14  ? 315 VAL A CG2 1 
ATOM 661  N N   . THR A 1 118 ? -13.857 -8.996  -26.203 1.00 68.67  ? 316 THR A N   1 
ATOM 662  C CA  . THR A 1 118 ? -14.717 -7.889  -26.609 1.00 71.57  ? 316 THR A CA  1 
ATOM 663  C C   . THR A 1 118 ? -15.875 -7.702  -25.636 1.00 62.68  ? 316 THR A C   1 
ATOM 664  O O   . THR A 1 118 ? -16.239 -6.567  -25.307 1.00 64.54  ? 316 THR A O   1 
ATOM 665  C CB  . THR A 1 118 ? -15.239 -8.121  -28.027 1.00 71.78  ? 316 THR A CB  1 
ATOM 666  O OG1 . THR A 1 118 ? -14.137 -8.371  -28.908 1.00 71.15  ? 316 THR A OG1 1 
ATOM 667  C CG2 . THR A 1 118 ? -16.002 -6.902  -28.520 1.00 73.07  ? 316 THR A CG2 1 
ATOM 668  N N   . LEU A 1 119 ? -16.467 -8.803  -25.165 1.00 60.18  ? 317 LEU A N   1 
ATOM 669  C CA  . LEU A 1 119 ? -17.562 -8.701  -24.206 1.00 61.47  ? 317 LEU A CA  1 
ATOM 670  C C   . LEU A 1 119 ? -17.091 -8.075  -22.900 1.00 63.45  ? 317 LEU A C   1 
ATOM 671  O O   . LEU A 1 119 ? -17.759 -7.196  -22.344 1.00 58.86  ? 317 LEU A O   1 
ATOM 672  C CB  . LEU A 1 119 ? -18.167 -10.082 -23.949 1.00 47.19  ? 317 LEU A CB  1 
ATOM 673  C CG  . LEU A 1 119 ? -18.850 -10.779 -25.127 1.00 58.60  ? 317 LEU A CG  1 
ATOM 674  C CD1 . LEU A 1 119 ? -19.386 -12.138 -24.706 1.00 51.87  ? 317 LEU A CD1 1 
ATOM 675  C CD2 . LEU A 1 119 ? -19.962 -9.913  -25.693 1.00 48.25  ? 317 LEU A CD2 1 
ATOM 676  N N   . LEU A 1 120 ? -15.935 -8.512  -22.398 1.00 61.90  ? 318 LEU A N   1 
ATOM 677  C CA  . LEU A 1 120 ? -15.391 -7.967  -21.162 1.00 57.65  ? 318 LEU A CA  1 
ATOM 678  C C   . LEU A 1 120 ? -14.795 -6.578  -21.343 1.00 67.18  ? 318 LEU A C   1 
ATOM 679  O O   . LEU A 1 120 ? -14.624 -5.861  -20.353 1.00 61.10  ? 318 LEU A O   1 
ATOM 680  C CB  . LEU A 1 120 ? -14.329 -8.913  -20.596 1.00 62.33  ? 318 LEU A CB  1 
ATOM 681  C CG  . LEU A 1 120 ? -14.815 -10.311 -20.206 1.00 61.34  ? 318 LEU A CG  1 
ATOM 682  C CD1 . LEU A 1 120 ? -13.659 -11.167 -19.712 1.00 73.68  ? 318 LEU A CD1 1 
ATOM 683  C CD2 . LEU A 1 120 ? -15.904 -10.217 -19.152 1.00 64.42  ? 318 LEU A CD2 1 
ATOM 684  N N   . LYS A 1 121 ? -14.477 -6.182  -22.578 1.00 67.52  ? 319 LYS A N   1 
ATOM 685  C CA  . LYS A 1 121 ? -13.907 -4.857  -22.805 1.00 72.14  ? 319 LYS A CA  1 
ATOM 686  C C   . LYS A 1 121 ? -14.955 -3.768  -22.618 1.00 62.33  ? 319 LYS A C   1 
ATOM 687  O O   . LYS A 1 121 ? -14.709 -2.765  -21.939 1.00 65.67  ? 319 LYS A O   1 
ATOM 688  C CB  . LYS A 1 121 ? -13.296 -4.782  -24.205 1.00 75.43  ? 319 LYS A CB  1 
ATOM 689  C CG  . LYS A 1 121 ? -12.764 -3.409  -24.582 1.00 80.00  ? 319 LYS A CG  1 
ATOM 690  C CD  . LYS A 1 121 ? -12.244 -3.396  -26.011 1.00 96.63  ? 319 LYS A CD  1 
ATOM 691  C CE  . LYS A 1 121 ? -11.768 -2.010  -26.418 1.00 96.37  ? 319 LYS A CE  1 
ATOM 692  N NZ  . LYS A 1 121 ? -11.289 -1.980  -27.828 1.00 87.71  ? 319 LYS A NZ  1 
ATOM 693  N N   . TYR A 1 122 ? -16.131 -3.948  -23.213 1.00 62.72  ? 320 TYR A N   1 
ATOM 694  C CA  . TYR A 1 122 ? -17.197 -2.957  -23.150 1.00 63.96  ? 320 TYR A CA  1 
ATOM 695  C C   . TYR A 1 122 ? -18.172 -3.199  -22.007 1.00 70.77  ? 320 TYR A C   1 
ATOM 696  O O   . TYR A 1 122 ? -19.111 -2.414  -21.839 1.00 75.30  ? 320 TYR A O   1 
ATOM 697  C CB  . TYR A 1 122 ? -17.967 -2.925  -24.475 1.00 68.56  ? 320 TYR A CB  1 
ATOM 698  C CG  . TYR A 1 122 ? -17.140 -2.487  -25.662 1.00 69.13  ? 320 TYR A CG  1 
ATOM 699  C CD1 . TYR A 1 122 ? -16.504 -3.418  -26.472 1.00 71.58  ? 320 TYR A CD1 1 
ATOM 700  C CD2 . TYR A 1 122 ? -16.998 -1.141  -25.974 1.00 73.94  ? 320 TYR A CD2 1 
ATOM 701  C CE1 . TYR A 1 122 ? -15.748 -3.022  -27.560 1.00 75.37  ? 320 TYR A CE1 1 
ATOM 702  C CE2 . TYR A 1 122 ? -16.244 -0.735  -27.059 1.00 83.79  ? 320 TYR A CE2 1 
ATOM 703  C CZ  . TYR A 1 122 ? -15.622 -1.679  -27.848 1.00 85.06  ? 320 TYR A CZ  1 
ATOM 704  O OH  . TYR A 1 122 ? -14.870 -1.279  -28.929 1.00 92.69  ? 320 TYR A OH  1 
ATOM 705  N N   . GLY A 1 123 ? -17.978 -4.253  -21.220 1.00 70.78  ? 321 GLY A N   1 
ATOM 706  C CA  . GLY A 1 123 ? -18.925 -4.582  -20.174 1.00 56.39  ? 321 GLY A CA  1 
ATOM 707  C C   . GLY A 1 123 ? -18.375 -4.464  -18.769 1.00 66.71  ? 321 GLY A C   1 
ATOM 708  O O   . GLY A 1 123 ? -19.145 -4.385  -17.808 1.00 59.11  ? 321 GLY A O   1 
ATOM 709  N N   . VAL A 1 124 ? -17.046 -4.443  -18.633 1.00 66.70  ? 322 VAL A N   1 
ATOM 710  C CA  . VAL A 1 124 ? -16.436 -4.420  -17.305 1.00 54.69  ? 322 VAL A CA  1 
ATOM 711  C C   . VAL A 1 124 ? -16.806 -3.141  -16.561 1.00 61.09  ? 322 VAL A C   1 
ATOM 712  O O   . VAL A 1 124 ? -17.004 -3.155  -15.340 1.00 64.75  ? 322 VAL A O   1 
ATOM 713  C CB  . VAL A 1 124 ? -14.909 -4.603  -17.410 1.00 55.40  ? 322 VAL A CB  1 
ATOM 714  C CG1 . VAL A 1 124 ? -14.273 -3.472  -18.210 1.00 62.47  ? 322 VAL A CG1 1 
ATOM 715  C CG2 . VAL A 1 124 ? -14.288 -4.706  -16.026 1.00 60.58  ? 322 VAL A CG2 1 
ATOM 716  N N   . HIS A 1 125 ? -16.920 -2.021  -17.280 1.00 63.35  ? 323 HIS A N   1 
ATOM 717  C CA  . HIS A 1 125 ? -17.302 -0.772  -16.628 1.00 60.97  ? 323 HIS A CA  1 
ATOM 718  C C   . HIS A 1 125 ? -18.765 -0.782  -16.209 1.00 64.91  ? 323 HIS A C   1 
ATOM 719  O O   . HIS A 1 125 ? -19.121 -0.175  -15.192 1.00 66.44  ? 323 HIS A O   1 
ATOM 720  C CB  . HIS A 1 125 ? -17.015 0.416   -17.546 1.00 68.03  ? 323 HIS A CB  1 
ATOM 721  C CG  . HIS A 1 125 ? -15.584 0.854   -17.536 1.00 72.19  ? 323 HIS A CG  1 
ATOM 722  N ND1 . HIS A 1 125 ? -14.966 1.408   -18.636 1.00 85.79  ? 323 HIS A ND1 1 
ATOM 723  C CD2 . HIS A 1 125 ? -14.650 0.825   -16.555 1.00 79.89  ? 323 HIS A CD2 1 
ATOM 724  C CE1 . HIS A 1 125 ? -13.712 1.697   -18.336 1.00 94.81  ? 323 HIS A CE1 1 
ATOM 725  N NE2 . HIS A 1 125 ? -13.495 1.353   -17.079 1.00 91.66  ? 323 HIS A NE2 1 
ATOM 726  N N   . GLU A 1 126 ? -19.624 -1.463  -16.970 1.00 62.28  ? 324 GLU A N   1 
ATOM 727  C CA  . GLU A 1 126 ? -21.018 -1.595  -16.562 1.00 58.49  ? 324 GLU A CA  1 
ATOM 728  C C   . GLU A 1 126 ? -21.158 -2.508  -15.351 1.00 53.31  ? 324 GLU A C   1 
ATOM 729  O O   . GLU A 1 126 ? -22.066 -2.317  -14.534 1.00 47.73  ? 324 GLU A O   1 
ATOM 730  C CB  . GLU A 1 126 ? -21.859 -2.117  -17.727 1.00 55.42  ? 324 GLU A CB  1 
ATOM 731  C CG  . GLU A 1 126 ? -21.788 -1.248  -18.973 1.00 61.39  ? 324 GLU A CG  1 
ATOM 732  C CD  . GLU A 1 126 ? -22.611 -1.801  -20.119 1.00 54.50  ? 324 GLU A CD  1 
ATOM 733  O OE1 . GLU A 1 126 ? -23.413 -2.729  -19.887 1.00 57.48  ? 324 GLU A OE1 1 
ATOM 734  O OE2 . GLU A 1 126 ? -22.454 -1.306  -21.255 1.00 67.32  ? 324 GLU A OE2 1 
ATOM 735  N N   . ILE A 1 127 ? -20.272 -3.496  -15.216 1.00 49.73  ? 325 ILE A N   1 
ATOM 736  C CA  . ILE A 1 127 ? -20.304 -4.366  -14.044 1.00 49.52  ? 325 ILE A CA  1 
ATOM 737  C C   . ILE A 1 127 ? -19.809 -3.616  -12.814 1.00 58.64  ? 325 ILE A C   1 
ATOM 738  O O   . ILE A 1 127 ? -20.427 -3.671  -11.745 1.00 58.02  ? 325 ILE A O   1 
ATOM 739  C CB  . ILE A 1 127 ? -19.475 -5.640  -14.293 1.00 50.64  ? 325 ILE A CB  1 
ATOM 740  C CG1 . ILE A 1 127 ? -19.966 -6.372  -15.542 1.00 54.10  ? 325 ILE A CG1 1 
ATOM 741  C CG2 . ILE A 1 127 ? -19.542 -6.560  -13.083 1.00 49.83  ? 325 ILE A CG2 1 
ATOM 742  C CD1 . ILE A 1 127 ? -21.401 -6.810  -15.464 1.00 56.15  ? 325 ILE A CD1 1 
ATOM 743  N N   . ILE A 1 128 ? -18.689 -2.900  -12.952 1.00 55.72  ? 326 ILE A N   1 
ATOM 744  C CA  . ILE A 1 128 ? -18.081 -2.217  -11.811 1.00 57.99  ? 326 ILE A CA  1 
ATOM 745  C C   . ILE A 1 128 ? -19.056 -1.222  -11.194 1.00 61.59  ? 326 ILE A C   1 
ATOM 746  O O   . ILE A 1 128 ? -19.181 -1.133  -9.967  1.00 56.44  ? 326 ILE A O   1 
ATOM 747  C CB  . ILE A 1 128 ? -16.767 -1.536  -12.238 1.00 58.77  ? 326 ILE A CB  1 
ATOM 748  C CG1 . ILE A 1 128 ? -15.687 -2.585  -12.510 1.00 55.69  ? 326 ILE A CG1 1 
ATOM 749  C CG2 . ILE A 1 128 ? -16.300 -0.549  -11.178 1.00 50.77  ? 326 ILE A CG2 1 
ATOM 750  C CD1 . ILE A 1 128 ? -14.378 -2.005  -13.000 1.00 61.17  ? 326 ILE A CD1 1 
ATOM 751  N N   . TYR A 1 129 ? -19.770 -0.466  -12.031 1.00 58.09  ? 327 TYR A N   1 
ATOM 752  C CA  . TYR A 1 129 ? -20.737 0.493   -11.511 1.00 58.02  ? 327 TYR A CA  1 
ATOM 753  C C   . TYR A 1 129 ? -21.968 -0.189  -10.929 1.00 54.60  ? 327 TYR A C   1 
ATOM 754  O O   . TYR A 1 129 ? -22.650 0.405   -10.087 1.00 47.13  ? 327 TYR A O   1 
ATOM 755  C CB  . TYR A 1 129 ? -21.137 1.479   -12.608 1.00 48.88  ? 327 TYR A CB  1 
ATOM 756  C CG  . TYR A 1 129 ? -19.972 2.295   -13.121 1.00 64.38  ? 327 TYR A CG  1 
ATOM 757  C CD1 . TYR A 1 129 ? -18.886 2.576   -12.300 1.00 67.72  ? 327 TYR A CD1 1 
ATOM 758  C CD2 . TYR A 1 129 ? -19.950 2.774   -14.423 1.00 76.26  ? 327 TYR A CD2 1 
ATOM 759  C CE1 . TYR A 1 129 ? -17.816 3.314   -12.759 1.00 71.16  ? 327 TYR A CE1 1 
ATOM 760  C CE2 . TYR A 1 129 ? -18.881 3.515   -14.893 1.00 77.43  ? 327 TYR A CE2 1 
ATOM 761  C CZ  . TYR A 1 129 ? -17.817 3.781   -14.055 1.00 80.54  ? 327 TYR A CZ  1 
ATOM 762  O OH  . TYR A 1 129 ? -16.750 4.517   -14.513 1.00 86.58  ? 327 TYR A OH  1 
ATOM 763  N N   . THR A 1 130 ? -22.266 -1.419  -11.354 1.00 55.13  ? 328 THR A N   1 
ATOM 764  C CA  . THR A 1 130 ? -23.324 -2.187  -10.707 1.00 46.05  ? 328 THR A CA  1 
ATOM 765  C C   . THR A 1 130 ? -22.864 -2.698  -9.347  1.00 44.99  ? 328 THR A C   1 
ATOM 766  O O   . THR A 1 130 ? -23.598 -2.607  -8.356  1.00 57.47  ? 328 THR A O   1 
ATOM 767  C CB  . THR A 1 130 ? -23.757 -3.349  -11.602 1.00 55.00  ? 328 THR A CB  1 
ATOM 768  O OG1 . THR A 1 130 ? -24.287 -2.837  -12.831 1.00 45.57  ? 328 THR A OG1 1 
ATOM 769  C CG2 . THR A 1 130 ? -24.820 -4.190  -10.910 1.00 44.25  ? 328 THR A CG2 1 
ATOM 770  N N   . MET A 1 131 ? -21.643 -3.239  -9.282  1.00 53.57  ? 329 MET A N   1 
ATOM 771  C CA  . MET A 1 131 ? -21.088 -3.670  -8.003  1.00 50.99  ? 329 MET A CA  1 
ATOM 772  C C   . MET A 1 131 ? -20.895 -2.494  -7.056  1.00 43.59  ? 329 MET A C   1 
ATOM 773  O O   . MET A 1 131 ? -20.988 -2.658  -5.834  1.00 52.17  ? 329 MET A O   1 
ATOM 774  C CB  . MET A 1 131 ? -19.753 -4.387  -8.220  1.00 50.24  ? 329 MET A CB  1 
ATOM 775  C CG  . MET A 1 131 ? -19.769 -5.457  -9.303  1.00 64.16  ? 329 MET A CG  1 
ATOM 776  S SD  . MET A 1 131 ? -20.500 -7.017  -8.781  1.00 68.52  ? 329 MET A SD  1 
ATOM 777  C CE  . MET A 1 131 ? -19.309 -7.548  -7.554  1.00 68.06  ? 329 MET A CE  1 
ATOM 778  N N   . LEU A 1 132 ? -20.629 -1.304  -7.600  1.00 41.65  ? 330 LEU A N   1 
ATOM 779  C CA  . LEU A 1 132 ? -20.380 -0.134  -6.765  1.00 46.60  ? 330 LEU A CA  1 
ATOM 780  C C   . LEU A 1 132 ? -21.625 0.288   -5.996  1.00 53.95  ? 330 LEU A C   1 
ATOM 781  O O   . LEU A 1 132 ? -21.514 0.817   -4.884  1.00 48.40  ? 330 LEU A O   1 
ATOM 782  C CB  . LEU A 1 132 ? -19.867 1.018   -7.629  1.00 46.85  ? 330 LEU A CB  1 
ATOM 783  C CG  . LEU A 1 132 ? -19.469 2.312   -6.920  1.00 59.41  ? 330 LEU A CG  1 
ATOM 784  C CD1 . LEU A 1 132 ? -18.413 2.040   -5.863  1.00 44.62  ? 330 LEU A CD1 1 
ATOM 785  C CD2 . LEU A 1 132 ? -18.972 3.337   -7.927  1.00 58.30  ? 330 LEU A CD2 1 
ATOM 786  N N   . ALA A 1 133 ? -22.813 0.063   -6.564  1.00 52.58  ? 331 ALA A N   1 
ATOM 787  C CA  . ALA A 1 133 ? -24.044 0.423   -5.868  1.00 49.05  ? 331 ALA A CA  1 
ATOM 788  C C   . ALA A 1 133 ? -24.247 -0.412  -4.611  1.00 47.20  ? 331 ALA A C   1 
ATOM 789  O O   . ALA A 1 133 ? -24.921 0.033   -3.675  1.00 53.60  ? 331 ALA A O   1 
ATOM 790  C CB  . ALA A 1 133 ? -25.243 0.272   -6.805  1.00 38.60  ? 331 ALA A CB  1 
ATOM 791  N N   . SER A 1 134 ? -23.675 -1.618  -4.570  1.00 45.18  ? 332 SER A N   1 
ATOM 792  C CA  . SER A 1 134 ? -23.798 -2.455  -3.382  1.00 43.50  ? 332 SER A CA  1 
ATOM 793  C C   . SER A 1 134 ? -23.050 -1.861  -2.195  1.00 39.04  ? 332 SER A C   1 
ATOM 794  O O   . SER A 1 134 ? -23.438 -2.088  -1.044  1.00 41.91  ? 332 SER A O   1 
ATOM 795  C CB  . SER A 1 134 ? -23.284 -3.864  -3.678  1.00 45.75  ? 332 SER A CB  1 
ATOM 796  O OG  . SER A 1 134 ? -24.029 -4.472  -4.718  1.00 48.16  ? 332 SER A OG  1 
ATOM 797  N N   . LEU A 1 135 ? -21.985 -1.104  -2.451  1.00 44.23  ? 333 LEU A N   1 
ATOM 798  C CA  . LEU A 1 135 ? -21.184 -0.494  -1.400  1.00 41.24  ? 333 LEU A CA  1 
ATOM 799  C C   . LEU A 1 135 ? -21.624 0.928   -1.078  1.00 49.60  ? 333 LEU A C   1 
ATOM 800  O O   . LEU A 1 135 ? -20.910 1.636   -0.361  1.00 47.39  ? 333 LEU A O   1 
ATOM 801  C CB  . LEU A 1 135 ? -19.705 -0.492  -1.796  1.00 45.44  ? 333 LEU A CB  1 
ATOM 802  C CG  . LEU A 1 135 ? -19.153 -1.715  -2.533  1.00 50.41  ? 333 LEU A CG  1 
ATOM 803  C CD1 . LEU A 1 135 ? -17.679 -1.517  -2.855  1.00 47.10  ? 333 LEU A CD1 1 
ATOM 804  C CD2 . LEU A 1 135 ? -19.362 -2.986  -1.729  1.00 41.50  ? 333 LEU A CD2 1 
ATOM 805  N N   . MET A 1 136 ? -22.775 1.359   -1.585  1.00 50.32  ? 334 MET A N   1 
ATOM 806  C CA  . MET A 1 136 ? -23.216 2.740   -1.468  1.00 38.68  ? 334 MET A CA  1 
ATOM 807  C C   . MET A 1 136 ? -24.530 2.828   -0.708  1.00 50.30  ? 334 MET A C   1 
ATOM 808  O O   . MET A 1 136 ? -25.420 1.990   -0.881  1.00 45.63  ? 334 MET A O   1 
ATOM 809  C CB  . MET A 1 136 ? -23.391 3.382   -2.848  1.00 47.43  ? 334 MET A CB  1 
ATOM 810  C CG  . MET A 1 136 ? -22.102 3.810   -3.520  1.00 48.71  ? 334 MET A CG  1 
ATOM 811  S SD  . MET A 1 136 ? -22.409 4.445   -5.179  1.00 60.70  ? 334 MET A SD  1 
ATOM 812  C CE  . MET A 1 136 ? -20.905 5.366   -5.475  1.00 55.93  ? 334 MET A CE  1 
ATOM 813  N N   . ASN A 1 137 ? -24.639 3.852   0.138   1.00 45.51  ? 335 ASN A N   1 
ATOM 814  C CA  . ASN A 1 137 ? -25.925 4.284   0.668   1.00 41.26  ? 335 ASN A CA  1 
ATOM 815  C C   . ASN A 1 137 ? -26.090 5.768   0.367   1.00 38.37  ? 335 ASN A C   1 
ATOM 816  O O   . ASN A 1 137 ? -25.289 6.340   -0.379  1.00 42.99  ? 335 ASN A O   1 
ATOM 817  C CB  . ASN A 1 137 ? -26.038 3.997   2.170   1.00 39.91  ? 335 ASN A CB  1 
ATOM 818  C CG  . ASN A 1 137 ? -24.891 4.584   2.975   1.00 49.23  ? 335 ASN A CG  1 
ATOM 819  O OD1 . ASN A 1 137 ? -24.101 5.383   2.474   1.00 53.95  ? 335 ASN A OD1 1 
ATOM 820  N ND2 . ASN A 1 137 ? -24.801 4.188   4.240   1.00 43.64  ? 335 ASN A ND2 1 
ATOM 821  N N   . LYS A 1 138 ? -27.111 6.407   0.940   1.00 46.69  ? 336 LYS A N   1 
ATOM 822  C CA  . LYS A 1 138 ? -27.344 7.815   0.639   1.00 45.84  ? 336 LYS A CA  1 
ATOM 823  C C   . LYS A 1 138 ? -26.294 8.734   1.252   1.00 52.67  ? 336 LYS A C   1 
ATOM 824  O O   . LYS A 1 138 ? -26.285 9.929   0.937   1.00 53.23  ? 336 LYS A O   1 
ATOM 825  C CB  . LYS A 1 138 ? -28.738 8.234   1.112   1.00 53.02  ? 336 LYS A CB  1 
ATOM 826  C CG  . LYS A 1 138 ? -28.799 8.710   2.554   1.00 68.96  ? 336 LYS A CG  1 
ATOM 827  C CD  . LYS A 1 138 ? -30.201 9.177   2.913   1.00 71.29  ? 336 LYS A CD  1 
ATOM 828  C CE  . LYS A 1 138 ? -30.202 10.005  4.188   1.00 69.84  ? 336 LYS A CE  1 
ATOM 829  N NZ  . LYS A 1 138 ? -29.438 11.274  4.021   1.00 69.38  ? 336 LYS A NZ  1 
ATOM 830  N N   . ASP A 1 139 ? -25.411 8.213   2.103   1.00 55.75  ? 337 ASP A N   1 
ATOM 831  C CA  . ASP A 1 139 ? -24.402 9.023   2.777   1.00 46.49  ? 337 ASP A CA  1 
ATOM 832  C C   . ASP A 1 139 ? -23.029 8.945   2.123   1.00 40.44  ? 337 ASP A C   1 
ATOM 833  O O   . ASP A 1 139 ? -22.316 9.951   2.082   1.00 40.28  ? 337 ASP A O   1 
ATOM 834  C CB  . ASP A 1 139 ? -24.289 8.608   4.247   1.00 50.67  ? 337 ASP A CB  1 
ATOM 835  C CG  . ASP A 1 139 ? -25.529 8.954   5.046   1.00 55.18  ? 337 ASP A CG  1 
ATOM 836  O OD1 . ASP A 1 139 ? -26.181 9.970   4.725   1.00 55.09  ? 337 ASP A OD1 1 
ATOM 837  O OD2 . ASP A 1 139 ? -25.852 8.211   5.996   1.00 49.19  ? 337 ASP A OD2 1 
ATOM 838  N N   . GLY A 1 140 ? -22.636 7.784   1.615   1.00 43.53  ? 338 GLY A N   1 
ATOM 839  C CA  . GLY A 1 140 ? -21.326 7.661   1.008   1.00 47.33  ? 338 GLY A CA  1 
ATOM 840  C C   . GLY A 1 140 ? -21.107 6.289   0.415   1.00 48.54  ? 338 GLY A C   1 
ATOM 841  O O   . GLY A 1 140 ? -22.053 5.530   0.199   1.00 44.13  ? 338 GLY A O   1 
ATOM 842  N N   . VAL A 1 141 ? -19.837 5.978   0.159   1.00 44.30  ? 339 VAL A N   1 
ATOM 843  C CA  . VAL A 1 141 ? -19.441 4.748   -0.514  1.00 41.68  ? 339 VAL A CA  1 
ATOM 844  C C   . VAL A 1 141 ? -18.399 4.030   0.335   1.00 58.09  ? 339 VAL A C   1 
ATOM 845  O O   . VAL A 1 141 ? -17.542 4.666   0.958   1.00 53.69  ? 339 VAL A O   1 
ATOM 846  C CB  . VAL A 1 141 ? -18.898 5.034   -1.932  1.00 48.34  ? 339 VAL A CB  1 
ATOM 847  C CG1 . VAL A 1 141 ? -17.755 6.040   -1.880  1.00 47.52  ? 339 VAL A CG1 1 
ATOM 848  C CG2 . VAL A 1 141 ? -18.458 3.748   -2.618  1.00 42.93  ? 339 VAL A CG2 1 
ATOM 849  N N   . LEU A 1 142 ? -18.485 2.701   0.368   1.00 56.48  ? 340 LEU A N   1 
ATOM 850  C CA  . LEU A 1 142 ? -17.516 1.883   1.084   1.00 48.38  ? 340 LEU A CA  1 
ATOM 851  C C   . LEU A 1 142 ? -16.266 1.701   0.230   1.00 47.80  ? 340 LEU A C   1 
ATOM 852  O O   . LEU A 1 142 ? -16.356 1.338   -0.947  1.00 55.16  ? 340 LEU A O   1 
ATOM 853  C CB  . LEU A 1 142 ? -18.131 0.527   1.430   1.00 45.67  ? 340 LEU A CB  1 
ATOM 854  C CG  . LEU A 1 142 ? -17.742 -0.122  2.758   1.00 60.98  ? 340 LEU A CG  1 
ATOM 855  C CD1 . LEU A 1 142 ? -18.085 0.795   3.921   1.00 54.15  ? 340 LEU A CD1 1 
ATOM 856  C CD2 . LEU A 1 142 ? -18.439 -1.466  2.912   1.00 59.42  ? 340 LEU A CD2 1 
ATOM 857  N N   . ILE A 1 143 ? -15.097 1.957   0.822   1.00 62.35  ? 341 ILE A N   1 
ATOM 858  C CA  . ILE A 1 143 ? -13.830 1.886   0.107   1.00 52.27  ? 341 ILE A CA  1 
ATOM 859  C C   . ILE A 1 143 ? -12.862 0.998   0.877   1.00 60.31  ? 341 ILE A C   1 
ATOM 860  O O   . ILE A 1 143 ? -13.067 0.685   2.052   1.00 64.16  ? 341 ILE A O   1 
ATOM 861  C CB  . ILE A 1 143 ? -13.206 3.282   -0.120  1.00 56.24  ? 341 ILE A CB  1 
ATOM 862  C CG1 . ILE A 1 143 ? -12.890 3.949   1.220   1.00 62.28  ? 341 ILE A CG1 1 
ATOM 863  C CG2 . ILE A 1 143 ? -14.133 4.156   -0.951  1.00 55.82  ? 341 ILE A CG2 1 
ATOM 864  C CD1 . ILE A 1 143 ? -12.288 5.331   1.089   1.00 53.73  ? 341 ILE A CD1 1 
ATOM 865  N N   . SER A 1 144 ? -11.794 0.593   0.185   1.00 57.94  ? 342 SER A N   1 
ATOM 866  C CA  . SER A 1 144 ? -10.718 -0.215  0.766   1.00 66.42  ? 342 SER A CA  1 
ATOM 867  C C   . SER A 1 144 ? -11.244 -1.535  1.328   1.00 60.60  ? 342 SER A C   1 
ATOM 868  O O   . SER A 1 144 ? -10.863 -1.960  2.421   1.00 72.43  ? 342 SER A O   1 
ATOM 869  C CB  . SER A 1 144 ? -9.957  0.567   1.840   1.00 67.00  ? 342 SER A CB  1 
ATOM 870  O OG  . SER A 1 144 ? -9.342  1.720   1.292   1.00 82.32  ? 342 SER A OG  1 
ATOM 871  N N   . GLU A 1 145 ? -12.121 -2.191  0.564   1.00 63.04  ? 343 GLU A N   1 
ATOM 872  C CA  . GLU A 1 145 ? -12.734 -3.461  0.964   1.00 68.55  ? 343 GLU A CA  1 
ATOM 873  C C   . GLU A 1 145 ? -13.395 -3.357  2.336   1.00 70.60  ? 343 GLU A C   1 
ATOM 874  O O   . GLU A 1 145 ? -13.307 -4.267  3.164   1.00 70.60  ? 343 GLU A O   1 
ATOM 875  C CB  . GLU A 1 145 ? -11.716 -4.604  0.938   1.00 82.39  ? 343 GLU A CB  1 
ATOM 876  C CG  . GLU A 1 145 ? -11.471 -5.192  -0.442  1.00 82.68  ? 343 GLU A CG  1 
ATOM 877  C CD  . GLU A 1 145 ? -10.937 -6.611  -0.379  1.00 96.09  ? 343 GLU A CD  1 
ATOM 878  O OE1 . GLU A 1 145 ? -10.834 -7.160  0.738   1.00 108.14 ? 343 GLU A OE1 1 
ATOM 879  O OE2 . GLU A 1 145 ? -10.623 -7.179  -1.447  1.00 101.43 ? 343 GLU A OE2 1 
ATOM 880  N N   . GLY A 1 146 ? -14.063 -2.233  2.581   1.00 65.37  ? 344 GLY A N   1 
ATOM 881  C CA  . GLY A 1 146 ? -14.782 -2.028  3.819   1.00 68.97  ? 344 GLY A CA  1 
ATOM 882  C C   . GLY A 1 146 ? -13.990 -1.386  4.936   1.00 57.24  ? 344 GLY A C   1 
ATOM 883  O O   . GLY A 1 146 ? -14.556 -1.141  6.008   1.00 64.78  ? 344 GLY A O   1 
ATOM 884  N N   . GLN A 1 147 ? -12.702 -1.107  4.729   1.00 67.05  ? 345 GLN A N   1 
ATOM 885  C CA  . GLN A 1 147 ? -11.903 -0.463  5.764   1.00 69.46  ? 345 GLN A CA  1 
ATOM 886  C C   . GLN A 1 147 ? -12.176 1.030   5.876   1.00 68.32  ? 345 GLN A C   1 
ATOM 887  O O   . GLN A 1 147 ? -11.941 1.611   6.941   1.00 75.20  ? 345 GLN A O   1 
ATOM 888  C CB  . GLN A 1 147 ? -10.412 -0.692  5.505   1.00 75.07  ? 345 GLN A CB  1 
ATOM 889  C CG  . GLN A 1 147 ? -9.938  -2.104  5.800   1.00 83.90  ? 345 GLN A CG  1 
ATOM 890  C CD  . GLN A 1 147 ? -8.447  -2.270  5.583   1.00 94.58  ? 345 GLN A CD  1 
ATOM 891  O OE1 . GLN A 1 147 ? -7.853  -1.605  4.735   1.00 90.46  ? 345 GLN A OE1 1 
ATOM 892  N NE2 . GLN A 1 147 ? -7.832  -3.157  6.357   1.00 97.96  ? 345 GLN A NE2 1 
ATOM 893  N N   . GLY A 1 148 ? -12.662 1.664   4.805   1.00 60.87  ? 346 GLY A N   1 
ATOM 894  C CA  . GLY A 1 148 ? -12.950 3.079   4.824   1.00 59.72  ? 346 GLY A CA  1 
ATOM 895  C C   . GLY A 1 148 ? -14.344 3.362   4.290   1.00 57.11  ? 346 GLY A C   1 
ATOM 896  O O   . GLY A 1 148 ? -14.994 2.499   3.694   1.00 65.72  ? 346 GLY A O   1 
ATOM 897  N N   . PHE A 1 149 ? -14.788 4.596   4.516   1.00 60.65  ? 347 PHE A N   1 
ATOM 898  C CA  . PHE A 1 149 ? -16.111 5.031   4.075   1.00 54.07  ? 347 PHE A CA  1 
ATOM 899  C C   . PHE A 1 149 ? -16.039 6.523   3.789   1.00 55.43  ? 347 PHE A C   1 
ATOM 900  O O   . PHE A 1 149 ? -15.955 7.329   4.720   1.00 57.57  ? 347 PHE A O   1 
ATOM 901  C CB  . PHE A 1 149 ? -17.171 4.720   5.129   1.00 57.78  ? 347 PHE A CB  1 
ATOM 902  C CG  . PHE A 1 149 ? -18.559 5.144   4.739   1.00 56.14  ? 347 PHE A CG  1 
ATOM 903  C CD1 . PHE A 1 149 ? -19.340 4.340   3.925   1.00 54.20  ? 347 PHE A CD1 1 
ATOM 904  C CD2 . PHE A 1 149 ? -19.086 6.341   5.195   1.00 55.97  ? 347 PHE A CD2 1 
ATOM 905  C CE1 . PHE A 1 149 ? -20.618 4.725   3.567   1.00 55.63  ? 347 PHE A CE1 1 
ATOM 906  C CE2 . PHE A 1 149 ? -20.364 6.731   4.841   1.00 61.66  ? 347 PHE A CE2 1 
ATOM 907  C CZ  . PHE A 1 149 ? -21.131 5.921   4.027   1.00 55.25  ? 347 PHE A CZ  1 
ATOM 908  N N   . MET A 1 150 ? -16.071 6.888   2.511   1.00 50.64  ? 348 MET A N   1 
ATOM 909  C CA  . MET A 1 150 ? -16.003 8.281   2.091   1.00 56.75  ? 348 MET A CA  1 
ATOM 910  C C   . MET A 1 150 ? -17.403 8.778   1.757   1.00 53.92  ? 348 MET A C   1 
ATOM 911  O O   . MET A 1 150 ? -18.130 8.134   0.994   1.00 53.12  ? 348 MET A O   1 
ATOM 912  C CB  . MET A 1 150 ? -15.075 8.443   0.887   1.00 44.19  ? 348 MET A CB  1 
ATOM 913  C CG  . MET A 1 150 ? -14.725 9.884   0.568   1.00 49.56  ? 348 MET A CG  1 
ATOM 914  S SD  . MET A 1 150 ? -13.318 10.010  -0.549  1.00 65.70  ? 348 MET A SD  1 
ATOM 915  C CE  . MET A 1 150 ? -12.077 9.101   0.368   1.00 51.57  ? 348 MET A CE  1 
ATOM 916  N N   . THR A 1 151 ? -17.772 9.923   2.326   1.00 38.49  ? 349 THR A N   1 
ATOM 917  C CA  . THR A 1 151 ? -19.127 10.428  2.187   1.00 41.42  ? 349 THR A CA  1 
ATOM 918  C C   . THR A 1 151 ? -19.373 10.964  0.779   1.00 55.23  ? 349 THR A C   1 
ATOM 919  O O   . THR A 1 151 ? -18.445 11.275  0.026   1.00 47.28  ? 349 THR A O   1 
ATOM 920  C CB  . THR A 1 151 ? -19.400 11.528  3.213   1.00 49.12  ? 349 THR A CB  1 
ATOM 921  O OG1 . THR A 1 151 ? -18.576 12.664  2.929   1.00 46.50  ? 349 THR A OG1 1 
ATOM 922  C CG2 . THR A 1 151 ? -19.095 11.028  4.616   1.00 43.55  ? 349 THR A CG2 1 
ATOM 923  N N   . ARG A 1 152 ? -20.657 11.071  0.431   1.00 45.48  ? 350 ARG A N   1 
ATOM 924  C CA  . ARG A 1 152 ? -21.031 11.558  -0.893  1.00 46.54  ? 350 ARG A CA  1 
ATOM 925  C C   . ARG A 1 152 ? -20.782 13.055  -1.024  1.00 49.90  ? 350 ARG A C   1 
ATOM 926  O O   . ARG A 1 152 ? -20.341 13.526  -2.080  1.00 46.35  ? 350 ARG A O   1 
ATOM 927  C CB  . ARG A 1 152 ? -22.498 11.229  -1.171  1.00 48.63  ? 350 ARG A CB  1 
ATOM 928  C CG  . ARG A 1 152 ? -23.016 11.752  -2.500  1.00 46.91  ? 350 ARG A CG  1 
ATOM 929  C CD  . ARG A 1 152 ? -24.477 11.383  -2.701  1.00 48.18  ? 350 ARG A CD  1 
ATOM 930  N NE  . ARG A 1 152 ? -25.001 11.892  -3.965  1.00 63.95  ? 350 ARG A NE  1 
ATOM 931  C CZ  . ARG A 1 152 ? -26.222 11.639  -4.424  1.00 54.67  ? 350 ARG A CZ  1 
ATOM 932  N NH1 . ARG A 1 152 ? -27.052 10.878  -3.723  1.00 60.16  ? 350 ARG A NH1 1 
ATOM 933  N NH2 . ARG A 1 152 ? -26.614 12.145  -5.584  1.00 57.18  ? 350 ARG A NH2 1 
ATOM 934  N N   . GLU A 1 153 ? -21.053 13.820  0.036   1.00 50.31  ? 351 GLU A N   1 
ATOM 935  C CA  . GLU A 1 153 ? -20.897 15.268  -0.045  1.00 50.95  ? 351 GLU A CA  1 
ATOM 936  C C   . GLU A 1 153 ? -19.432 15.684  -0.082  1.00 54.28  ? 351 GLU A C   1 
ATOM 937  O O   . GLU A 1 153 ? -19.099 16.706  -0.691  1.00 55.79  ? 351 GLU A O   1 
ATOM 938  C CB  . GLU A 1 153 ? -21.614 15.943  1.125   1.00 38.63  ? 351 GLU A CB  1 
ATOM 939  C CG  . GLU A 1 153 ? -23.128 15.976  0.985   1.00 44.19  ? 351 GLU A CG  1 
ATOM 940  C CD  . GLU A 1 153 ? -23.590 16.817  -0.193  1.00 53.32  ? 351 GLU A CD  1 
ATOM 941  O OE1 . GLU A 1 153 ? -22.850 17.738  -0.601  1.00 54.42  ? 351 GLU A OE1 1 
ATOM 942  O OE2 . GLU A 1 153 ? -24.694 16.556  -0.713  1.00 56.46  ? 351 GLU A OE2 1 
ATOM 943  N N   . PHE A 1 154 ? -18.546 14.917  0.558   1.00 50.34  ? 352 PHE A N   1 
ATOM 944  C CA  . PHE A 1 154 ? -17.125 15.245  0.496   1.00 54.47  ? 352 PHE A CA  1 
ATOM 945  C C   . PHE A 1 154 ? -16.568 15.009  -0.901  1.00 51.36  ? 352 PHE A C   1 
ATOM 946  O O   . PHE A 1 154 ? -15.705 15.763  -1.367  1.00 59.56  ? 352 PHE A O   1 
ATOM 947  C CB  . PHE A 1 154 ? -16.346 14.432  1.529   1.00 51.82  ? 352 PHE A CB  1 
ATOM 948  C CG  . PHE A 1 154 ? -14.860 14.628  1.454   1.00 56.78  ? 352 PHE A CG  1 
ATOM 949  C CD1 . PHE A 1 154 ? -14.283 15.813  1.879   1.00 58.67  ? 352 PHE A CD1 1 
ATOM 950  C CD2 . PHE A 1 154 ? -14.039 13.629  0.958   1.00 57.52  ? 352 PHE A CD2 1 
ATOM 951  C CE1 . PHE A 1 154 ? -12.916 15.999  1.810   1.00 61.32  ? 352 PHE A CE1 1 
ATOM 952  C CE2 . PHE A 1 154 ? -12.670 13.808  0.887   1.00 61.86  ? 352 PHE A CE2 1 
ATOM 953  C CZ  . PHE A 1 154 ? -12.108 14.995  1.314   1.00 60.37  ? 352 PHE A CZ  1 
ATOM 954  N N   . LEU A 1 155 ? -17.047 13.967  -1.584  1.00 54.12  ? 353 LEU A N   1 
ATOM 955  C CA  . LEU A 1 155 ? -16.619 13.723  -2.957  1.00 48.60  ? 353 LEU A CA  1 
ATOM 956  C C   . LEU A 1 155 ? -17.078 14.842  -3.883  1.00 50.63  ? 353 LEU A C   1 
ATOM 957  O O   . LEU A 1 155 ? -16.367 15.210  -4.825  1.00 59.65  ? 353 LEU A O   1 
ATOM 958  C CB  . LEU A 1 155 ? -17.151 12.373  -3.437  1.00 48.07  ? 353 LEU A CB  1 
ATOM 959  C CG  . LEU A 1 155 ? -16.463 11.140  -2.851  1.00 48.02  ? 353 LEU A CG  1 
ATOM 960  C CD1 . LEU A 1 155 ? -17.303 9.896   -3.078  1.00 47.51  ? 353 LEU A CD1 1 
ATOM 961  C CD2 . LEU A 1 155 ? -15.087 10.975  -3.471  1.00 51.90  ? 353 LEU A CD2 1 
ATOM 962  N N   . LYS A 1 156 ? -18.263 15.397  -3.628  1.00 56.23  ? 354 LYS A N   1 
ATOM 963  C CA  . LYS A 1 156 ? -18.774 16.490  -4.444  1.00 56.56  ? 354 LYS A CA  1 
ATOM 964  C C   . LYS A 1 156 ? -18.107 17.820  -4.121  1.00 55.80  ? 354 LYS A C   1 
ATOM 965  O O   . LYS A 1 156 ? -18.110 18.722  -4.966  1.00 61.69  ? 354 LYS A O   1 
ATOM 966  C CB  . LYS A 1 156 ? -20.292 16.603  -4.268  1.00 53.25  ? 354 LYS A CB  1 
ATOM 967  C CG  . LYS A 1 156 ? -20.986 17.469  -5.308  1.00 63.26  ? 354 LYS A CG  1 
ATOM 968  C CD  . LYS A 1 156 ? -22.492 17.259  -5.288  1.00 67.94  ? 354 LYS A CD  1 
ATOM 969  C CE  . LYS A 1 156 ? -23.082 17.576  -3.925  1.00 55.69  ? 354 LYS A CE  1 
ATOM 970  N NZ  . LYS A 1 156 ? -24.554 17.352  -3.894  1.00 57.24  ? 354 LYS A NZ  1 
ATOM 971  N N   . SER A 1 157 ? -17.525 17.960  -2.928  1.00 62.07  ? 355 SER A N   1 
ATOM 972  C CA  . SER A 1 157 ? -16.847 19.194  -2.550  1.00 52.51  ? 355 SER A CA  1 
ATOM 973  C C   . SER A 1 157 ? -15.459 19.322  -3.163  1.00 54.16  ? 355 SER A C   1 
ATOM 974  O O   . SER A 1 157 ? -14.841 20.384  -3.032  1.00 61.01  ? 355 SER A O   1 
ATOM 975  C CB  . SER A 1 157 ? -16.740 19.294  -1.027  1.00 55.05  ? 355 SER A CB  1 
ATOM 976  O OG  . SER A 1 157 ? -15.857 18.312  -0.512  1.00 59.03  ? 355 SER A OG  1 
ATOM 977  N N   . LEU A 1 158 ? -14.956 18.279  -3.817  1.00 57.38  ? 356 LEU A N   1 
ATOM 978  C CA  . LEU A 1 158 ? -13.643 18.343  -4.439  1.00 54.35  ? 356 LEU A CA  1 
ATOM 979  C C   . LEU A 1 158 ? -13.649 19.335  -5.599  1.00 67.56  ? 356 LEU A C   1 
ATOM 980  O O   . LEU A 1 158 ? -14.700 19.737  -6.107  1.00 65.28  ? 356 LEU A O   1 
ATOM 981  C CB  . LEU A 1 158 ? -13.213 16.960  -4.927  1.00 62.12  ? 356 LEU A CB  1 
ATOM 982  C CG  . LEU A 1 158 ? -13.167 15.860  -3.863  1.00 57.00  ? 356 LEU A CG  1 
ATOM 983  C CD1 . LEU A 1 158 ? -12.721 14.539  -4.471  1.00 56.45  ? 356 LEU A CD1 1 
ATOM 984  C CD2 . LEU A 1 158 ? -12.256 16.262  -2.713  1.00 62.07  ? 356 LEU A CD2 1 
ATOM 985  N N   . ARG A 1 159 ? -12.450 19.730  -6.018  1.00 72.25  ? 357 ARG A N   1 
ATOM 986  C CA  . ARG A 1 159 ? -12.322 20.747  -7.051  1.00 85.17  ? 357 ARG A CA  1 
ATOM 987  C C   . ARG A 1 159 ? -12.804 20.220  -8.399  1.00 80.68  ? 357 ARG A C   1 
ATOM 988  O O   . ARG A 1 159 ? -12.758 19.019  -8.679  1.00 85.88  ? 357 ARG A O   1 
ATOM 989  C CB  . ARG A 1 159 ? -10.873 21.225  -7.160  1.00 88.21  ? 357 ARG A CB  1 
ATOM 990  C CG  . ARG A 1 159 ? -9.905  20.204  -7.737  1.00 98.96  ? 357 ARG A CG  1 
ATOM 991  C CD  . ARG A 1 159 ? -8.503  20.786  -7.840  1.00 105.69 ? 357 ARG A CD  1 
ATOM 992  N NE  . ARG A 1 159 ? -7.583  19.897  -8.544  1.00 115.15 ? 357 ARG A NE  1 
ATOM 993  C CZ  . ARG A 1 159 ? -7.351  19.945  -9.852  1.00 114.81 ? 357 ARG A CZ  1 
ATOM 994  N NH1 . ARG A 1 159 ? -7.973  20.843  -10.605 1.00 108.83 ? 357 ARG A NH1 1 
ATOM 995  N NH2 . ARG A 1 159 ? -6.497  19.098  -10.409 1.00 99.14  ? 357 ARG A NH2 1 
ATOM 996  N N   . LYS A 1 160 ? -13.279 21.140  -9.231  1.00 82.36  ? 358 LYS A N   1 
ATOM 997  C CA  . LYS A 1 160 ? -13.774 20.780  -10.551 1.00 92.02  ? 358 LYS A CA  1 
ATOM 998  C C   . LYS A 1 160 ? -12.622 20.272  -11.418 1.00 91.77  ? 358 LYS A C   1 
ATOM 999  O O   . LYS A 1 160 ? -11.521 20.830  -11.376 1.00 92.24  ? 358 LYS A O   1 
ATOM 1000 C CB  . LYS A 1 160 ? -14.437 21.995  -11.205 1.00 86.62  ? 358 LYS A CB  1 
ATOM 1001 C CG  . LYS A 1 160 ? -15.618 21.690  -12.114 1.00 95.58  ? 358 LYS A CG  1 
ATOM 1002 C CD  . LYS A 1 160 ? -15.207 21.659  -13.577 1.00 97.98  ? 358 LYS A CD  1 
ATOM 1003 C CE  . LYS A 1 160 ? -16.420 21.736  -14.491 1.00 93.58  ? 358 LYS A CE  1 
ATOM 1004 N NZ  . LYS A 1 160 ? -17.417 20.672  -14.191 1.00 87.84  ? 358 LYS A NZ  1 
ATOM 1005 N N   . PRO A 1 161 ? -12.839 19.212  -12.215 1.00 92.99  ? 359 PRO A N   1 
ATOM 1006 C CA  . PRO A 1 161 ? -14.087 18.456  -12.342 1.00 100.04 ? 359 PRO A CA  1 
ATOM 1007 C C   . PRO A 1 161 ? -14.134 17.196  -11.482 1.00 91.10  ? 359 PRO A C   1 
ATOM 1008 O O   . PRO A 1 161 ? -15.007 16.352  -11.690 1.00 90.70  ? 359 PRO A O   1 
ATOM 1009 C CB  . PRO A 1 161 ? -14.101 18.088  -13.823 1.00 97.01  ? 359 PRO A CB  1 
ATOM 1010 C CG  . PRO A 1 161 ? -12.652 17.861  -14.130 1.00 90.13  ? 359 PRO A CG  1 
ATOM 1011 C CD  . PRO A 1 161 ? -11.862 18.807  -13.241 1.00 90.37  ? 359 PRO A CD  1 
ATOM 1012 N N   . PHE A 1 162 ? -13.205 17.069  -10.532 1.00 84.56  ? 360 PHE A N   1 
ATOM 1013 C CA  . PHE A 1 162 ? -13.164 15.880  -9.689  1.00 85.08  ? 360 PHE A CA  1 
ATOM 1014 C C   . PHE A 1 162 ? -14.386 15.763  -8.788  1.00 76.15  ? 360 PHE A C   1 
ATOM 1015 O O   . PHE A 1 162 ? -14.698 14.659  -8.329  1.00 68.43  ? 360 PHE A O   1 
ATOM 1016 C CB  . PHE A 1 162 ? -11.887 15.875  -8.848  1.00 86.38  ? 360 PHE A CB  1 
ATOM 1017 C CG  . PHE A 1 162 ? -10.628 15.782  -9.662  1.00 88.35  ? 360 PHE A CG  1 
ATOM 1018 C CD1 . PHE A 1 162 ? -10.095 14.548  -9.999  1.00 92.77  ? 360 PHE A CD1 1 
ATOM 1019 C CD2 . PHE A 1 162 ? -9.979  16.927  -10.093 1.00 97.80  ? 360 PHE A CD2 1 
ATOM 1020 C CE1 . PHE A 1 162 ? -8.938  14.459  -10.750 1.00 109.47 ? 360 PHE A CE1 1 
ATOM 1021 C CE2 . PHE A 1 162 ? -8.822  16.844  -10.844 1.00 100.17 ? 360 PHE A CE2 1 
ATOM 1022 C CZ  . PHE A 1 162 ? -8.300  15.609  -11.172 1.00 105.35 ? 360 PHE A CZ  1 
ATOM 1023 N N   . GLY A 1 163 ? -15.084 16.869  -8.527  1.00 80.98  ? 361 GLY A N   1 
ATOM 1024 C CA  . GLY A 1 163 ? -16.317 16.814  -7.763  1.00 72.70  ? 361 GLY A CA  1 
ATOM 1025 C C   . GLY A 1 163 ? -17.497 16.241  -8.519  1.00 73.85  ? 361 GLY A C   1 
ATOM 1026 O O   . GLY A 1 163 ? -18.535 15.978  -7.902  1.00 73.74  ? 361 GLY A O   1 
ATOM 1027 N N   . ASP A 1 164 ? -17.364 16.045  -9.830  1.00 77.18  ? 362 ASP A N   1 
ATOM 1028 C CA  . ASP A 1 164 ? -18.412 15.460  -10.655 1.00 74.55  ? 362 ASP A CA  1 
ATOM 1029 C C   . ASP A 1 164 ? -18.092 14.028  -11.066 1.00 73.99  ? 362 ASP A C   1 
ATOM 1030 O O   . ASP A 1 164 ? -18.773 13.475  -11.935 1.00 77.43  ? 362 ASP A O   1 
ATOM 1031 C CB  . ASP A 1 164 ? -18.645 16.319  -11.900 1.00 79.56  ? 362 ASP A CB  1 
ATOM 1032 C CG  . ASP A 1 164 ? -18.836 17.785  -11.569 1.00 88.13  ? 362 ASP A CG  1 
ATOM 1033 O OD1 . ASP A 1 164 ? -19.513 18.087  -10.563 1.00 90.19  ? 362 ASP A OD1 1 
ATOM 1034 O OD2 . ASP A 1 164 ? -18.304 18.637  -12.312 1.00 103.26 ? 362 ASP A OD2 1 
ATOM 1035 N N   . PHE A 1 165 ? -17.072 13.417  -10.461 1.00 65.10  ? 363 PHE A N   1 
ATOM 1036 C CA  . PHE A 1 165 ? -16.647 12.081  -10.866 1.00 66.43  ? 363 PHE A CA  1 
ATOM 1037 C C   . PHE A 1 165 ? -17.570 11.006  -10.302 1.00 71.49  ? 363 PHE A C   1 
ATOM 1038 O O   . PHE A 1 165 ? -18.032 10.126  -11.037 1.00 68.13  ? 363 PHE A O   1 
ATOM 1039 C CB  . PHE A 1 165 ? -15.202 11.841  -10.421 1.00 71.07  ? 363 PHE A CB  1 
ATOM 1040 C CG  . PHE A 1 165 ? -14.616 10.550  -10.920 1.00 92.55  ? 363 PHE A CG  1 
ATOM 1041 C CD1 . PHE A 1 165 ? -14.649 9.408   -10.136 1.00 95.59  ? 363 PHE A CD1 1 
ATOM 1042 C CD2 . PHE A 1 165 ? -14.024 10.482  -12.170 1.00 88.16  ? 363 PHE A CD2 1 
ATOM 1043 C CE1 . PHE A 1 165 ? -14.108 8.221   -10.592 1.00 86.21  ? 363 PHE A CE1 1 
ATOM 1044 C CE2 . PHE A 1 165 ? -13.481 9.297   -12.631 1.00 90.82  ? 363 PHE A CE2 1 
ATOM 1045 C CZ  . PHE A 1 165 ? -13.523 8.166   -11.841 1.00 87.51  ? 363 PHE A CZ  1 
ATOM 1046 N N   . MET A 1 166 ? -17.850 11.063  -9.000  1.00 67.43  ? 364 MET A N   1 
ATOM 1047 C CA  . MET A 1 166 ? -18.644 10.041  -8.331  1.00 61.61  ? 364 MET A CA  1 
ATOM 1048 C C   . MET A 1 166 ? -20.118 10.401  -8.207  1.00 50.87  ? 364 MET A C   1 
ATOM 1049 O O   . MET A 1 166 ? -20.925 9.521   -7.889  1.00 60.62  ? 364 MET A O   1 
ATOM 1050 C CB  . MET A 1 166 ? -18.074 9.762   -6.935  1.00 54.78  ? 364 MET A CB  1 
ATOM 1051 C CG  . MET A 1 166 ? -16.667 9.192   -6.944  1.00 65.10  ? 364 MET A CG  1 
ATOM 1052 S SD  . MET A 1 166 ? -16.594 7.559   -7.702  1.00 79.06  ? 364 MET A SD  1 
ATOM 1053 C CE  . MET A 1 166 ? -17.650 6.629   -6.596  1.00 65.63  ? 364 MET A CE  1 
ATOM 1054 N N   . GLU A 1 167 ? -20.486 11.658  -8.445  1.00 50.35  ? 365 GLU A N   1 
ATOM 1055 C CA  . GLU A 1 167 ? -21.883 12.056  -8.292  1.00 51.40  ? 365 GLU A CA  1 
ATOM 1056 C C   . GLU A 1 167 ? -22.834 11.323  -9.235  1.00 55.30  ? 365 GLU A C   1 
ATOM 1057 O O   . GLU A 1 167 ? -23.922 10.931  -8.778  1.00 52.08  ? 365 GLU A O   1 
ATOM 1058 C CB  . GLU A 1 167 ? -22.009 13.577  -8.456  1.00 58.20  ? 365 GLU A CB  1 
ATOM 1059 C CG  . GLU A 1 167 ? -23.418 14.115  -8.240  1.00 71.20  ? 365 GLU A CG  1 
ATOM 1060 C CD  . GLU A 1 167 ? -23.916 13.917  -6.819  1.00 61.12  ? 365 GLU A CD  1 
ATOM 1061 O OE1 . GLU A 1 167 ? -23.080 13.754  -5.905  1.00 60.80  ? 365 GLU A OE1 1 
ATOM 1062 O OE2 . GLU A 1 167 ? -25.148 13.925  -6.616  1.00 61.86  ? 365 GLU A OE2 1 
ATOM 1063 N N   . PRO A 1 168 ? -22.522 11.112  -10.521 1.00 57.04  ? 366 PRO A N   1 
ATOM 1064 C CA  . PRO A 1 168 ? -23.429 10.301  -11.350 1.00 61.11  ? 366 PRO A CA  1 
ATOM 1065 C C   . PRO A 1 168 ? -23.580 8.873   -10.856 1.00 55.13  ? 366 PRO A C   1 
ATOM 1066 O O   . PRO A 1 168 ? -24.631 8.258   -11.077 1.00 60.86  ? 366 PRO A O   1 
ATOM 1067 C CB  . PRO A 1 168 ? -22.777 10.351  -12.739 1.00 54.21  ? 366 PRO A CB  1 
ATOM 1068 C CG  . PRO A 1 168 ? -21.970 11.595  -12.730 1.00 60.23  ? 366 PRO A CG  1 
ATOM 1069 C CD  . PRO A 1 168 ? -21.447 11.713  -11.333 1.00 58.27  ? 366 PRO A CD  1 
ATOM 1070 N N   . LYS A 1 169 ? -22.560 8.325   -10.191 1.00 51.79  ? 367 LYS A N   1 
ATOM 1071 C CA  . LYS A 1 169 ? -22.661 6.963   -9.676  1.00 53.64  ? 367 LYS A CA  1 
ATOM 1072 C C   . LYS A 1 169 ? -23.582 6.888   -8.466  1.00 46.59  ? 367 LYS A C   1 
ATOM 1073 O O   . LYS A 1 169 ? -24.276 5.882   -8.280  1.00 42.89  ? 367 LYS A O   1 
ATOM 1074 C CB  . LYS A 1 169 ? -21.273 6.423   -9.320  1.00 51.35  ? 367 LYS A CB  1 
ATOM 1075 C CG  . LYS A 1 169 ? -20.416 6.016   -10.517 1.00 62.40  ? 367 LYS A CG  1 
ATOM 1076 C CD  . LYS A 1 169 ? -19.800 7.218   -11.221 1.00 58.06  ? 367 LYS A CD  1 
ATOM 1077 C CE  . LYS A 1 169 ? -19.008 6.797   -12.447 1.00 68.32  ? 367 LYS A CE  1 
ATOM 1078 N NZ  . LYS A 1 169 ? -18.463 7.972   -13.181 1.00 73.24  ? 367 LYS A NZ  1 
ATOM 1079 N N   . PHE A 1 170 ? -23.604 7.934   -7.635  1.00 47.68  ? 368 PHE A N   1 
ATOM 1080 C CA  . PHE A 1 170 ? -24.487 7.934   -6.474  1.00 50.15  ? 368 PHE A CA  1 
ATOM 1081 C C   . PHE A 1 170 ? -25.946 8.086   -6.885  1.00 52.60  ? 368 PHE A C   1 
ATOM 1082 O O   . PHE A 1 170 ? -26.827 7.434   -6.313  1.00 57.55  ? 368 PHE A O   1 
ATOM 1083 C CB  . PHE A 1 170 ? -24.087 9.045   -5.504  1.00 47.51  ? 368 PHE A CB  1 
ATOM 1084 C CG  . PHE A 1 170 ? -22.943 8.681   -4.603  1.00 54.71  ? 368 PHE A CG  1 
ATOM 1085 C CD1 . PHE A 1 170 ? -23.139 7.838   -3.522  1.00 56.02  ? 368 PHE A CD1 1 
ATOM 1086 C CD2 . PHE A 1 170 ? -21.675 9.189   -4.829  1.00 46.91  ? 368 PHE A CD2 1 
ATOM 1087 C CE1 . PHE A 1 170 ? -22.090 7.501   -2.687  1.00 53.72  ? 368 PHE A CE1 1 
ATOM 1088 C CE2 . PHE A 1 170 ? -20.622 8.857   -3.997  1.00 51.41  ? 368 PHE A CE2 1 
ATOM 1089 C CZ  . PHE A 1 170 ? -20.830 8.012   -2.925  1.00 54.30  ? 368 PHE A CZ  1 
ATOM 1090 N N   . GLU A 1 171 ? -26.222 8.946   -7.869  1.00 59.04  ? 369 GLU A N   1 
ATOM 1091 C CA  . GLU A 1 171 ? -27.594 9.115   -8.338  1.00 60.25  ? 369 GLU A CA  1 
ATOM 1092 C C   . GLU A 1 171 ? -28.132 7.823   -8.937  1.00 45.87  ? 369 GLU A C   1 
ATOM 1093 O O   . GLU A 1 171 ? -29.316 7.501   -8.780  1.00 52.72  ? 369 GLU A O   1 
ATOM 1094 C CB  . GLU A 1 171 ? -27.664 10.252  -9.357  1.00 59.76  ? 369 GLU A CB  1 
ATOM 1095 C CG  . GLU A 1 171 ? -27.293 11.611  -8.791  1.00 63.10  ? 369 GLU A CG  1 
ATOM 1096 C CD  . GLU A 1 171 ? -27.294 12.701  -9.843  1.00 88.53  ? 369 GLU A CD  1 
ATOM 1097 O OE1 . GLU A 1 171 ? -27.522 12.384  -11.029 1.00 95.73  ? 369 GLU A OE1 1 
ATOM 1098 O OE2 . GLU A 1 171 ? -27.066 13.876  -9.484  1.00 92.39  ? 369 GLU A OE2 1 
ATOM 1099 N N   . PHE A 1 172 ? -27.275 7.069   -9.627  1.00 44.08  ? 370 PHE A N   1 
ATOM 1100 C CA  . PHE A 1 172 ? -27.682 5.763   -10.134 1.00 46.49  ? 370 PHE A CA  1 
ATOM 1101 C C   . PHE A 1 172 ? -27.899 4.773   -8.998  1.00 46.89  ? 370 PHE A C   1 
ATOM 1102 O O   . PHE A 1 172 ? -28.851 3.984   -9.028  1.00 45.47  ? 370 PHE A O   1 
ATOM 1103 C CB  . PHE A 1 172 ? -26.635 5.234   -11.113 1.00 45.03  ? 370 PHE A CB  1 
ATOM 1104 C CG  . PHE A 1 172 ? -26.748 3.759   -11.387 1.00 54.37  ? 370 PHE A CG  1 
ATOM 1105 C CD1 . PHE A 1 172 ? -27.678 3.279   -12.294 1.00 45.68  ? 370 PHE A CD1 1 
ATOM 1106 C CD2 . PHE A 1 172 ? -25.917 2.855   -10.745 1.00 46.93  ? 370 PHE A CD2 1 
ATOM 1107 C CE1 . PHE A 1 172 ? -27.783 1.924   -12.550 1.00 43.49  ? 370 PHE A CE1 1 
ATOM 1108 C CE2 . PHE A 1 172 ? -26.018 1.499   -10.996 1.00 49.19  ? 370 PHE A CE2 1 
ATOM 1109 C CZ  . PHE A 1 172 ? -26.952 1.034   -11.899 1.00 48.67  ? 370 PHE A CZ  1 
ATOM 1110 N N   . ALA A 1 173 ? -27.026 4.801   -7.987  1.00 39.39  ? 371 ALA A N   1 
ATOM 1111 C CA  . ALA A 1 173 ? -27.104 3.820   -6.910  1.00 43.68  ? 371 ALA A CA  1 
ATOM 1112 C C   . ALA A 1 173 ? -28.369 3.999   -6.081  1.00 42.95  ? 371 ALA A C   1 
ATOM 1113 O O   . ALA A 1 173 ? -28.971 3.013   -5.641  1.00 47.60  ? 371 ALA A O   1 
ATOM 1114 C CB  . ALA A 1 173 ? -25.864 3.914   -6.022  1.00 44.90  ? 371 ALA A CB  1 
ATOM 1115 N N   . VAL A 1 174 ? -28.784 5.247   -5.850  1.00 43.72  ? 372 VAL A N   1 
ATOM 1116 C CA  . VAL A 1 174 ? -30.010 5.492   -5.094  1.00 54.31  ? 372 VAL A CA  1 
ATOM 1117 C C   . VAL A 1 174 ? -31.206 4.882   -5.812  1.00 42.92  ? 372 VAL A C   1 
ATOM 1118 O O   . VAL A 1 174 ? -32.070 4.252   -5.188  1.00 53.13  ? 372 VAL A O   1 
ATOM 1119 C CB  . VAL A 1 174 ? -30.199 7.002   -4.857  1.00 59.11  ? 372 VAL A CB  1 
ATOM 1120 C CG1 . VAL A 1 174 ? -31.544 7.274   -4.201  1.00 51.78  ? 372 VAL A CG1 1 
ATOM 1121 C CG2 . VAL A 1 174 ? -29.069 7.550   -4.000  1.00 51.04  ? 372 VAL A CG2 1 
ATOM 1122 N N   . LYS A 1 175 ? -31.269 5.046   -7.134  1.00 49.86  ? 373 LYS A N   1 
ATOM 1123 C CA  . LYS A 1 175 ? -32.356 4.449   -7.901  1.00 50.16  ? 373 LYS A CA  1 
ATOM 1124 C C   . LYS A 1 175 ? -32.186 2.939   -8.017  1.00 48.38  ? 373 LYS A C   1 
ATOM 1125 O O   . LYS A 1 175 ? -33.170 2.192   -7.977  1.00 55.51  ? 373 LYS A O   1 
ATOM 1126 C CB  . LYS A 1 175 ? -32.427 5.088   -9.287  1.00 59.53  ? 373 LYS A CB  1 
ATOM 1127 C CG  . LYS A 1 175 ? -32.635 6.594   -9.269  1.00 60.41  ? 373 LYS A CG  1 
ATOM 1128 C CD  . LYS A 1 175 ? -32.281 7.212   -10.613 1.00 62.41  ? 373 LYS A CD  1 
ATOM 1129 C CE  . LYS A 1 175 ? -33.050 6.555   -11.747 1.00 76.06  ? 373 LYS A CE  1 
ATOM 1130 N NZ  . LYS A 1 175 ? -32.644 7.094   -13.075 1.00 82.76  ? 373 LYS A NZ  1 
ATOM 1131 N N   . PHE A 1 176 ? -30.943 2.472   -8.157  1.00 36.90  ? 374 PHE A N   1 
ATOM 1132 C CA  . PHE A 1 176 ? -30.703 1.044   -8.338  1.00 44.25  ? 374 PHE A CA  1 
ATOM 1133 C C   . PHE A 1 176 ? -30.936 0.276   -7.042  1.00 43.59  ? 374 PHE A C   1 
ATOM 1134 O O   . PHE A 1 176 ? -31.591 -0.773  -7.041  1.00 45.46  ? 374 PHE A O   1 
ATOM 1135 C CB  . PHE A 1 176 ? -29.284 0.815   -8.858  1.00 46.38  ? 374 PHE A CB  1 
ATOM 1136 C CG  . PHE A 1 176 ? -29.024 -0.591  -9.316  1.00 38.80  ? 374 PHE A CG  1 
ATOM 1137 C CD1 . PHE A 1 176 ? -29.482 -1.026  -10.548 1.00 39.60  ? 374 PHE A CD1 1 
ATOM 1138 C CD2 . PHE A 1 176 ? -28.315 -1.474  -8.520  1.00 32.92  ? 374 PHE A CD2 1 
ATOM 1139 C CE1 . PHE A 1 176 ? -29.243 -2.318  -10.976 1.00 32.73  ? 374 PHE A CE1 1 
ATOM 1140 C CE2 . PHE A 1 176 ? -28.072 -2.768  -8.942  1.00 36.22  ? 374 PHE A CE2 1 
ATOM 1141 C CZ  . PHE A 1 176 ? -28.537 -3.191  -10.172 1.00 38.56  ? 374 PHE A CZ  1 
ATOM 1142 N N   . ASN A 1 177 ? -30.410 0.785   -5.924  1.00 42.03  ? 375 ASN A N   1 
ATOM 1143 C CA  . ASN A 1 177 ? -30.622 0.125   -4.639  1.00 42.54  ? 375 ASN A CA  1 
ATOM 1144 C C   . ASN A 1 177 ? -32.076 0.183   -4.192  1.00 40.58  ? 375 ASN A C   1 
ATOM 1145 O O   . ASN A 1 177 ? -32.466 -0.576  -3.299  1.00 42.65  ? 375 ASN A O   1 
ATOM 1146 C CB  . ASN A 1 177 ? -29.724 0.743   -3.565  1.00 42.59  ? 375 ASN A CB  1 
ATOM 1147 C CG  . ASN A 1 177 ? -28.252 0.481   -3.814  1.00 44.37  ? 375 ASN A CG  1 
ATOM 1148 O OD1 . ASN A 1 177 ? -27.890 -0.395  -4.600  1.00 55.83  ? 375 ASN A OD1 1 
ATOM 1149 N ND2 . ASN A 1 177 ? -27.394 1.235   -3.138  1.00 39.30  ? 375 ASN A ND2 1 
ATOM 1150 N N   . ALA A 1 178 ? -32.883 1.064   -4.788  1.00 46.15  ? 376 ALA A N   1 
ATOM 1151 C CA  . ALA A 1 178 ? -34.313 1.074   -4.504  1.00 46.56  ? 376 ALA A CA  1 
ATOM 1152 C C   . ALA A 1 178 ? -35.003 -0.194  -4.987  1.00 45.00  ? 376 ALA A C   1 
ATOM 1153 O O   . ALA A 1 178 ? -36.117 -0.487  -4.541  1.00 49.57  ? 376 ALA A O   1 
ATOM 1154 C CB  . ALA A 1 178 ? -34.969 2.301   -5.139  1.00 52.47  ? 376 ALA A CB  1 
ATOM 1155 N N   . LEU A 1 179 ? -34.371 -0.945  -5.892  1.00 44.78  ? 377 LEU A N   1 
ATOM 1156 C CA  . LEU A 1 179 ? -34.907 -2.232  -6.314  1.00 46.84  ? 377 LEU A CA  1 
ATOM 1157 C C   . LEU A 1 179 ? -34.663 -3.327  -5.285  1.00 41.23  ? 377 LEU A C   1 
ATOM 1158 O O   . LEU A 1 179 ? -35.359 -4.348  -5.312  1.00 46.00  ? 377 LEU A O   1 
ATOM 1159 C CB  . LEU A 1 179 ? -34.298 -2.639  -7.658  1.00 41.97  ? 377 LEU A CB  1 
ATOM 1160 C CG  . LEU A 1 179 ? -34.438 -1.621  -8.792  1.00 49.59  ? 377 LEU A CG  1 
ATOM 1161 C CD1 . LEU A 1 179 ? -33.873 -2.175  -10.092 1.00 43.40  ? 377 LEU A CD1 1 
ATOM 1162 C CD2 . LEU A 1 179 ? -35.891 -1.204  -8.968  1.00 53.77  ? 377 LEU A CD2 1 
ATOM 1163 N N   . GLU A 1 180 ? -33.691 -3.134  -4.390  1.00 48.88  ? 378 GLU A N   1 
ATOM 1164 C CA  . GLU A 1 180 ? -33.420 -4.053  -3.283  1.00 44.56  ? 378 GLU A CA  1 
ATOM 1165 C C   . GLU A 1 180 ? -33.084 -5.458  -3.784  1.00 48.54  ? 378 GLU A C   1 
ATOM 1166 O O   . GLU A 1 180 ? -33.688 -6.452  -3.377  1.00 49.94  ? 378 GLU A O   1 
ATOM 1167 C CB  . GLU A 1 180 ? -34.589 -4.085  -2.296  1.00 47.11  ? 378 GLU A CB  1 
ATOM 1168 C CG  . GLU A 1 180 ? -34.688 -2.845  -1.422  1.00 63.42  ? 378 GLU A CG  1 
ATOM 1169 C CD  . GLU A 1 180 ? -35.826 -2.924  -0.425  1.00 80.31  ? 378 GLU A CD  1 
ATOM 1170 O OE1 . GLU A 1 180 ? -36.934 -3.346  -0.818  1.00 92.37  ? 378 GLU A OE1 1 
ATOM 1171 O OE2 . GLU A 1 180 ? -35.610 -2.572  0.753   1.00 84.82  ? 378 GLU A OE2 1 
ATOM 1172 N N   . LEU A 1 181 ? -32.100 -5.533  -4.674  1.00 48.37  ? 379 LEU A N   1 
ATOM 1173 C CA  . LEU A 1 181 ? -31.586 -6.816  -5.124  1.00 43.44  ? 379 LEU A CA  1 
ATOM 1174 C C   . LEU A 1 181 ? -30.580 -7.359  -4.118  1.00 41.48  ? 379 LEU A C   1 
ATOM 1175 O O   . LEU A 1 181 ? -29.921 -6.604  -3.398  1.00 47.36  ? 379 LEU A O   1 
ATOM 1176 C CB  . LEU A 1 181 ? -30.920 -6.682  -6.493  1.00 40.53  ? 379 LEU A CB  1 
ATOM 1177 C CG  . LEU A 1 181 ? -31.685 -5.939  -7.587  1.00 44.76  ? 379 LEU A CG  1 
ATOM 1178 C CD1 . LEU A 1 181 ? -30.815 -5.805  -8.823  1.00 43.56  ? 379 LEU A CD1 1 
ATOM 1179 C CD2 . LEU A 1 181 ? -32.988 -6.649  -7.918  1.00 38.06  ? 379 LEU A CD2 1 
ATOM 1180 N N   . ASP A 1 182 ? -30.466 -8.681  -4.069  1.00 42.58  ? 380 ASP A N   1 
ATOM 1181 C CA  . ASP A 1 182 ? -29.459 -9.341  -3.253  1.00 45.11  ? 380 ASP A CA  1 
ATOM 1182 C C   . ASP A 1 182 ? -28.411 -9.984  -4.158  1.00 49.24  ? 380 ASP A C   1 
ATOM 1183 O O   . ASP A 1 182 ? -28.438 -9.837  -5.384  1.00 44.57  ? 380 ASP A O   1 
ATOM 1184 C CB  . ASP A 1 182 ? -30.102 -10.363 -2.309  1.00 36.98  ? 380 ASP A CB  1 
ATOM 1185 C CG  . ASP A 1 182 ? -30.952 -11.391 -3.035  1.00 52.22  ? 380 ASP A CG  1 
ATOM 1186 O OD1 . ASP A 1 182 ? -30.930 -11.429 -4.282  1.00 51.91  ? 380 ASP A OD1 1 
ATOM 1187 O OD2 . ASP A 1 182 ? -31.651 -12.167 -2.350  1.00 52.32  ? 380 ASP A OD2 1 
ATOM 1188 N N   . ASP A 1 183 ? -27.474 -10.703 -3.536  1.00 45.74  ? 381 ASP A N   1 
ATOM 1189 C CA  . ASP A 1 183 ? -26.381 -11.307 -4.291  1.00 47.39  ? 381 ASP A CA  1 
ATOM 1190 C C   . ASP A 1 183 ? -26.885 -12.343 -5.288  1.00 41.26  ? 381 ASP A C   1 
ATOM 1191 O O   . ASP A 1 183 ? -26.285 -12.518 -6.355  1.00 46.13  ? 381 ASP A O   1 
ATOM 1192 C CB  . ASP A 1 183 ? -25.369 -11.935 -3.334  1.00 41.83  ? 381 ASP A CB  1 
ATOM 1193 C CG  . ASP A 1 183 ? -24.649 -10.902 -2.490  1.00 46.85  ? 381 ASP A CG  1 
ATOM 1194 O OD1 . ASP A 1 183 ? -24.286 -9.839  -3.034  1.00 44.76  ? 381 ASP A OD1 1 
ATOM 1195 O OD2 . ASP A 1 183 ? -24.450 -11.151 -1.283  1.00 56.45  ? 381 ASP A OD2 1 
ATOM 1196 N N   . SER A 1 184 ? -27.979 -13.037 -4.965  1.00 41.23  ? 382 SER A N   1 
ATOM 1197 C CA  . SER A 1 184 ? -28.522 -14.026 -5.891  1.00 44.01  ? 382 SER A CA  1 
ATOM 1198 C C   . SER A 1 184 ? -29.088 -13.361 -7.140  1.00 42.93  ? 382 SER A C   1 
ATOM 1199 O O   . SER A 1 184 ? -28.970 -13.903 -8.245  1.00 45.45  ? 382 SER A O   1 
ATOM 1200 C CB  . SER A 1 184 ? -29.591 -14.867 -5.196  1.00 34.19  ? 382 SER A CB  1 
ATOM 1201 O OG  . SER A 1 184 ? -29.037 -15.609 -4.124  1.00 60.43  ? 382 SER A OG  1 
ATOM 1202 N N   . ASP A 1 185 ? -29.706 -12.187 -6.986  1.00 43.16  ? 383 ASP A N   1 
ATOM 1203 C CA  . ASP A 1 185 ? -30.196 -11.455 -8.149  1.00 44.41  ? 383 ASP A CA  1 
ATOM 1204 C C   . ASP A 1 185 ? -29.044 -10.870 -8.956  1.00 45.29  ? 383 ASP A C   1 
ATOM 1205 O O   . ASP A 1 185 ? -29.037 -10.950 -10.190 1.00 43.82  ? 383 ASP A O   1 
ATOM 1206 C CB  . ASP A 1 185 ? -31.149 -10.342 -7.713  1.00 45.16  ? 383 ASP A CB  1 
ATOM 1207 C CG  . ASP A 1 185 ? -32.310 -10.854 -6.886  1.00 39.03  ? 383 ASP A CG  1 
ATOM 1208 O OD1 . ASP A 1 185 ? -32.733 -12.009 -7.098  1.00 43.16  ? 383 ASP A OD1 1 
ATOM 1209 O OD2 . ASP A 1 185 ? -32.800 -10.097 -6.022  1.00 45.76  ? 383 ASP A OD2 1 
ATOM 1210 N N   . LEU A 1 186 ? -28.060 -10.279 -8.273  1.00 37.47  ? 384 LEU A N   1 
ATOM 1211 C CA  . LEU A 1 186 ? -26.969 -9.605  -8.968  1.00 42.62  ? 384 LEU A CA  1 
ATOM 1212 C C   . LEU A 1 186 ? -26.077 -10.586 -9.719  1.00 46.84  ? 384 LEU A C   1 
ATOM 1213 O O   . LEU A 1 186 ? -25.511 -10.229 -10.757 1.00 48.63  ? 384 LEU A O   1 
ATOM 1214 C CB  . LEU A 1 186 ? -26.143 -8.790  -7.973  1.00 39.50  ? 384 LEU A CB  1 
ATOM 1215 C CG  . LEU A 1 186 ? -26.868 -7.625  -7.297  1.00 49.32  ? 384 LEU A CG  1 
ATOM 1216 C CD1 . LEU A 1 186 ? -26.029 -7.049  -6.166  1.00 42.53  ? 384 LEU A CD1 1 
ATOM 1217 C CD2 . LEU A 1 186 ? -27.208 -6.548  -8.315  1.00 44.54  ? 384 LEU A CD2 1 
ATOM 1218 N N   . ALA A 1 187 ? -25.939 -11.816 -9.217  1.00 45.70  ? 385 ALA A N   1 
ATOM 1219 C CA  . ALA A 1 187 ? -25.080 -12.796 -9.876  1.00 41.01  ? 385 ALA A CA  1 
ATOM 1220 C C   . ALA A 1 187 ? -25.545 -13.062 -11.302 1.00 43.59  ? 385 ALA A C   1 
ATOM 1221 O O   . ALA A 1 187 ? -24.737 -13.093 -12.237 1.00 44.92  ? 385 ALA A O   1 
ATOM 1222 C CB  . ALA A 1 187 ? -25.049 -14.093 -9.067  1.00 44.59  ? 385 ALA A CB  1 
ATOM 1223 N N   . ILE A 1 188 ? -26.852 -13.252 -11.487 1.00 37.59  ? 386 ILE A N   1 
ATOM 1224 C CA  . ILE A 1 188 ? -27.382 -13.486 -12.825 1.00 44.30  ? 386 ILE A CA  1 
ATOM 1225 C C   . ILE A 1 188 ? -27.406 -12.189 -13.623 1.00 43.94  ? 386 ILE A C   1 
ATOM 1226 O O   . ILE A 1 188 ? -27.141 -12.182 -14.831 1.00 44.70  ? 386 ILE A O   1 
ATOM 1227 C CB  . ILE A 1 188 ? -28.779 -14.124 -12.736 1.00 45.62  ? 386 ILE A CB  1 
ATOM 1228 C CG1 . ILE A 1 188 ? -28.806 -15.183 -11.633 1.00 40.91  ? 386 ILE A CG1 1 
ATOM 1229 C CG2 . ILE A 1 188 ? -29.169 -14.740 -14.069 1.00 37.36  ? 386 ILE A CG2 1 
ATOM 1230 C CD1 . ILE A 1 188 ? -30.175 -15.759 -11.380 1.00 46.67  ? 386 ILE A CD1 1 
ATOM 1231 N N   . PHE A 1 189 ? -27.722 -11.073 -12.961 1.00 47.92  ? 387 PHE A N   1 
ATOM 1232 C CA  . PHE A 1 189 ? -27.759 -9.783  -13.645 1.00 40.55  ? 387 PHE A CA  1 
ATOM 1233 C C   . PHE A 1 189 ? -26.387 -9.408  -14.191 1.00 49.97  ? 387 PHE A C   1 
ATOM 1234 O O   . PHE A 1 189 ? -26.278 -8.869  -15.299 1.00 49.14  ? 387 PHE A O   1 
ATOM 1235 C CB  . PHE A 1 189 ? -28.279 -8.708  -12.690 1.00 40.27  ? 387 PHE A CB  1 
ATOM 1236 C CG  . PHE A 1 189 ? -28.294 -7.324  -13.276 1.00 34.09  ? 387 PHE A CG  1 
ATOM 1237 C CD1 . PHE A 1 189 ? -29.287 -6.941  -14.162 1.00 49.48  ? 387 PHE A CD1 1 
ATOM 1238 C CD2 . PHE A 1 189 ? -27.325 -6.398  -12.924 1.00 40.95  ? 387 PHE A CD2 1 
ATOM 1239 C CE1 . PHE A 1 189 ? -29.306 -5.666  -14.696 1.00 59.64  ? 387 PHE A CE1 1 
ATOM 1240 C CE2 . PHE A 1 189 ? -27.339 -5.122  -13.453 1.00 43.88  ? 387 PHE A CE2 1 
ATOM 1241 C CZ  . PHE A 1 189 ? -28.330 -4.756  -14.341 1.00 40.88  ? 387 PHE A CZ  1 
ATOM 1242 N N   . ILE A 1 190 ? -25.328 -9.688  -13.428 1.00 47.94  ? 388 ILE A N   1 
ATOM 1243 C CA  . ILE A 1 190 ? -23.973 -9.441  -13.915 1.00 45.80  ? 388 ILE A CA  1 
ATOM 1244 C C   . ILE A 1 190 ? -23.682 -10.306 -15.136 1.00 44.89  ? 388 ILE A C   1 
ATOM 1245 O O   . ILE A 1 190 ? -23.025 -9.866  -16.087 1.00 43.06  ? 388 ILE A O   1 
ATOM 1246 C CB  . ILE A 1 190 ? -22.950 -9.682  -12.788 1.00 47.24  ? 388 ILE A CB  1 
ATOM 1247 C CG1 . ILE A 1 190 ? -23.068 -8.597  -11.713 1.00 61.34  ? 388 ILE A CG1 1 
ATOM 1248 C CG2 . ILE A 1 190 ? -21.531 -9.750  -13.337 1.00 54.36  ? 388 ILE A CG2 1 
ATOM 1249 C CD1 . ILE A 1 190 ? -23.070 -7.188  -12.257 1.00 52.34  ? 388 ILE A CD1 1 
ATOM 1250 N N   . ALA A 1 191 ? -24.184 -11.543 -15.137 1.00 41.81  ? 389 ALA A N   1 
ATOM 1251 C CA  . ALA A 1 191 ? -23.932 -12.446 -16.254 1.00 43.24  ? 389 ALA A CA  1 
ATOM 1252 C C   . ALA A 1 191 ? -24.635 -11.990 -17.526 1.00 49.30  ? 389 ALA A C   1 
ATOM 1253 O O   . ALA A 1 191 ? -24.105 -12.182 -18.626 1.00 45.96  ? 389 ALA A O   1 
ATOM 1254 C CB  . ALA A 1 191 ? -24.365 -13.866 -15.888 1.00 38.30  ? 389 ALA A CB  1 
ATOM 1255 N N   . VAL A 1 192 ? -25.821 -11.390 -17.403 1.00 41.96  ? 390 VAL A N   1 
ATOM 1256 C CA  . VAL A 1 192 ? -26.547 -10.939 -18.587 1.00 43.90  ? 390 VAL A CA  1 
ATOM 1257 C C   . VAL A 1 192 ? -25.819 -9.777  -19.252 1.00 55.57  ? 390 VAL A C   1 
ATOM 1258 O O   . VAL A 1 192 ? -25.804 -9.659  -20.484 1.00 57.60  ? 390 VAL A O   1 
ATOM 1259 C CB  . VAL A 1 192 ? -27.995 -10.566 -18.216 1.00 40.94  ? 390 VAL A CB  1 
ATOM 1260 C CG1 . VAL A 1 192 ? -28.745 -10.059 -19.437 1.00 54.45  ? 390 VAL A CG1 1 
ATOM 1261 C CG2 . VAL A 1 192 ? -28.712 -11.763 -17.613 1.00 34.14  ? 390 VAL A CG2 1 
ATOM 1262 N N   . ILE A 1 193 ? -25.198 -8.907  -18.453 1.00 47.47  ? 391 ILE A N   1 
ATOM 1263 C CA  . ILE A 1 193 ? -24.475 -7.770  -19.013 1.00 49.95  ? 391 ILE A CA  1 
ATOM 1264 C C   . ILE A 1 193 ? -23.271 -8.242  -19.819 1.00 51.44  ? 391 ILE A C   1 
ATOM 1265 O O   . ILE A 1 193 ? -22.950 -7.674  -20.871 1.00 55.30  ? 391 ILE A O   1 
ATOM 1266 C CB  . ILE A 1 193 ? -24.059 -6.801  -17.891 1.00 49.73  ? 391 ILE A CB  1 
ATOM 1267 C CG1 . ILE A 1 193 ? -25.288 -6.286  -17.140 1.00 51.76  ? 391 ILE A CG1 1 
ATOM 1268 C CG2 . ILE A 1 193 ? -23.252 -5.640  -18.452 1.00 49.51  ? 391 ILE A CG2 1 
ATOM 1269 C CD1 . ILE A 1 193 ? -24.953 -5.309  -16.035 1.00 39.97  ? 391 ILE A CD1 1 
ATOM 1270 N N   . ILE A 1 194 ? -22.590 -9.288  -19.346 1.00 52.16  ? 392 ILE A N   1 
ATOM 1271 C CA  . ILE A 1 194 ? -21.399 -9.776  -20.035 1.00 52.10  ? 392 ILE A CA  1 
ATOM 1272 C C   . ILE A 1 194 ? -21.761 -10.330 -21.407 1.00 58.85  ? 392 ILE A C   1 
ATOM 1273 O O   . ILE A 1 194 ? -21.081 -10.055 -22.403 1.00 62.08  ? 392 ILE A O   1 
ATOM 1274 C CB  . ILE A 1 194 ? -20.678 -10.828 -19.173 1.00 51.24  ? 392 ILE A CB  1 
ATOM 1275 C CG1 . ILE A 1 194 ? -20.276 -10.229 -17.824 1.00 47.97  ? 392 ILE A CG1 1 
ATOM 1276 C CG2 . ILE A 1 194 ? -19.457 -11.369 -19.900 1.00 56.97  ? 392 ILE A CG2 1 
ATOM 1277 C CD1 . ILE A 1 194 ? -19.595 -11.212 -16.897 1.00 51.62  ? 392 ILE A CD1 1 
ATOM 1278 N N   . LEU A 1 195 ? -22.836 -11.108 -21.486 1.00 49.76  ? 393 LEU A N   1 
ATOM 1279 C CA  . LEU A 1 195 ? -23.260 -11.727 -22.742 1.00 49.90  ? 393 LEU A CA  1 
ATOM 1280 C C   . LEU A 1 195 ? -24.157 -10.796 -23.553 1.00 51.54  ? 393 LEU A C   1 
ATOM 1281 O O   . LEU A 1 195 ? -25.259 -11.158 -23.961 1.00 55.59  ? 393 LEU A O   1 
ATOM 1282 C CB  . LEU A 1 195 ? -23.958 -13.054 -22.460 1.00 52.12  ? 393 LEU A CB  1 
ATOM 1283 C CG  . LEU A 1 195 ? -23.082 -14.279 -22.174 1.00 48.31  ? 393 LEU A CG  1 
ATOM 1284 C CD1 . LEU A 1 195 ? -22.030 -14.453 -23.262 1.00 53.84  ? 393 LEU A CD1 1 
ATOM 1285 C CD2 . LEU A 1 195 ? -22.432 -14.215 -20.796 1.00 47.26  ? 393 LEU A CD2 1 
ATOM 1286 N N   . SER A 1 196 ? -23.681 -9.577  -23.794 1.00 55.53  ? 394 SER A N   1 
ATOM 1287 C CA  . SER A 1 196 ? -24.404 -8.600  -24.601 1.00 64.09  ? 394 SER A CA  1 
ATOM 1288 C C   . SER A 1 196 ? -23.984 -8.773  -26.056 1.00 53.86  ? 394 SER A C   1 
ATOM 1289 O O   . SER A 1 196 ? -22.826 -8.526  -26.409 1.00 61.48  ? 394 SER A O   1 
ATOM 1290 C CB  . SER A 1 196 ? -24.128 -7.181  -24.111 1.00 55.17  ? 394 SER A CB  1 
ATOM 1291 O OG  . SER A 1 196 ? -24.513 -7.025  -22.756 1.00 65.67  ? 394 SER A OG  1 
ATOM 1292 N N   . GLY A 1 197 ? -24.922 -9.195  -26.900 1.00 55.28  ? 395 GLY A N   1 
ATOM 1293 C CA  . GLY A 1 197 ? -24.644 -9.449  -28.297 1.00 61.77  ? 395 GLY A CA  1 
ATOM 1294 C C   . GLY A 1 197 ? -24.531 -8.230  -29.181 1.00 64.05  ? 395 GLY A C   1 
ATOM 1295 O O   . GLY A 1 197 ? -24.439 -8.374  -30.403 1.00 68.28  ? 395 GLY A O   1 
ATOM 1296 N N   . ASP A 1 198 ? -24.532 -7.025  -28.609 1.00 60.33  ? 396 ASP A N   1 
ATOM 1297 C CA  . ASP A 1 198 ? -24.458 -5.792  -29.382 1.00 53.46  ? 396 ASP A CA  1 
ATOM 1298 C C   . ASP A 1 198 ? -23.134 -5.060  -29.187 1.00 58.90  ? 396 ASP A C   1 
ATOM 1299 O O   . ASP A 1 198 ? -23.035 -3.871  -29.507 1.00 54.78  ? 396 ASP A O   1 
ATOM 1300 C CB  . ASP A 1 198 ? -25.629 -4.873  -29.029 1.00 52.69  ? 396 ASP A CB  1 
ATOM 1301 C CG  . ASP A 1 198 ? -25.681 -4.531  -27.552 1.00 65.24  ? 396 ASP A CG  1 
ATOM 1302 O OD1 . ASP A 1 198 ? -24.933 -5.150  -26.766 1.00 67.11  ? 396 ASP A OD1 1 
ATOM 1303 O OD2 . ASP A 1 198 ? -26.470 -3.639  -27.177 1.00 73.45  ? 396 ASP A OD2 1 
ATOM 1304 N N   . ARG A 1 199 ? -22.117 -5.741  -28.668 1.00 63.08  ? 397 ARG A N   1 
ATOM 1305 C CA  . ARG A 1 199 ? -20.824 -5.100  -28.481 1.00 70.98  ? 397 ARG A CA  1 
ATOM 1306 C C   . ARG A 1 199 ? -20.158 -4.863  -29.835 1.00 66.98  ? 397 ARG A C   1 
ATOM 1307 O O   . ARG A 1 199 ? -20.276 -5.695  -30.740 1.00 62.39  ? 397 ARG A O   1 
ATOM 1308 C CB  . ARG A 1 199 ? -19.918 -5.955  -27.596 1.00 57.41  ? 397 ARG A CB  1 
ATOM 1309 C CG  . ARG A 1 199 ? -20.506 -6.298  -26.237 1.00 65.04  ? 397 ARG A CG  1 
ATOM 1310 C CD  . ARG A 1 199 ? -20.876 -5.053  -25.446 1.00 62.83  ? 397 ARG A CD  1 
ATOM 1311 N NE  . ARG A 1 199 ? -21.315 -5.388  -24.094 1.00 59.87  ? 397 ARG A NE  1 
ATOM 1312 C CZ  . ARG A 1 199 ? -21.788 -4.506  -23.219 1.00 62.77  ? 397 ARG A CZ  1 
ATOM 1313 N NH1 . ARG A 1 199 ? -21.889 -3.227  -23.551 1.00 54.00  ? 397 ARG A NH1 1 
ATOM 1314 N NH2 . ARG A 1 199 ? -22.162 -4.905  -22.011 1.00 61.00  ? 397 ARG A NH2 1 
ATOM 1315 N N   . PRO A 1 200 ? -19.460 -3.741  -30.007 1.00 68.86  ? 398 PRO A N   1 
ATOM 1316 C CA  . PRO A 1 200 ? -18.806 -3.469  -31.295 1.00 72.22  ? 398 PRO A CA  1 
ATOM 1317 C C   . PRO A 1 200 ? -17.644 -4.424  -31.533 1.00 82.52  ? 398 PRO A C   1 
ATOM 1318 O O   . PRO A 1 200 ? -16.746 -4.553  -30.699 1.00 73.45  ? 398 PRO A O   1 
ATOM 1319 C CB  . PRO A 1 200 ? -18.322 -2.020  -31.153 1.00 70.22  ? 398 PRO A CB  1 
ATOM 1320 C CG  . PRO A 1 200 ? -19.101 -1.454  -30.000 1.00 74.51  ? 398 PRO A CG  1 
ATOM 1321 C CD  . PRO A 1 200 ? -19.341 -2.607  -29.078 1.00 68.91  ? 398 PRO A CD  1 
ATOM 1322 N N   . GLY A 1 201 ? -17.671 -5.095  -32.682 1.00 76.74  ? 399 GLY A N   1 
ATOM 1323 C CA  . GLY A 1 201 ? -16.588 -5.977  -33.063 1.00 69.32  ? 399 GLY A CA  1 
ATOM 1324 C C   . GLY A 1 201 ? -16.743 -7.419  -32.643 1.00 70.22  ? 399 GLY A C   1 
ATOM 1325 O O   . GLY A 1 201 ? -15.736 -8.091  -32.393 1.00 72.30  ? 399 GLY A O   1 
ATOM 1326 N N   . LEU A 1 202 ? -17.972 -7.922  -32.558 1.00 72.61  ? 400 LEU A N   1 
ATOM 1327 C CA  . LEU A 1 202 ? -18.217 -9.311  -32.190 1.00 71.85  ? 400 LEU A CA  1 
ATOM 1328 C C   . LEU A 1 202 ? -18.190 -10.177 -33.444 1.00 73.70  ? 400 LEU A C   1 
ATOM 1329 O O   . LEU A 1 202 ? -18.948 -9.933  -34.390 1.00 70.85  ? 400 LEU A O   1 
ATOM 1330 C CB  . LEU A 1 202 ? -19.553 -9.453  -31.462 1.00 68.60  ? 400 LEU A CB  1 
ATOM 1331 C CG  . LEU A 1 202 ? -19.614 -8.864  -30.051 1.00 70.11  ? 400 LEU A CG  1 
ATOM 1332 C CD1 . LEU A 1 202 ? -21.000 -9.041  -29.451 1.00 64.65  ? 400 LEU A CD1 1 
ATOM 1333 C CD2 . LEU A 1 202 ? -18.557 -9.501  -29.162 1.00 66.44  ? 400 LEU A CD2 1 
ATOM 1334 N N   . LEU A 1 203 ? -17.316 -11.186 -33.450 1.00 76.32  ? 401 LEU A N   1 
ATOM 1335 C CA  . LEU A 1 203 ? -17.194 -12.051 -34.618 1.00 68.49  ? 401 LEU A CA  1 
ATOM 1336 C C   . LEU A 1 203 ? -18.383 -12.996 -34.736 1.00 69.78  ? 401 LEU A C   1 
ATOM 1337 O O   . LEU A 1 203 ? -18.930 -13.181 -35.830 1.00 78.62  ? 401 LEU A O   1 
ATOM 1338 C CB  . LEU A 1 203 ? -15.885 -12.839 -34.552 1.00 69.87  ? 401 LEU A CB  1 
ATOM 1339 C CG  . LEU A 1 203 ? -14.602 -12.010 -34.459 1.00 72.56  ? 401 LEU A CG  1 
ATOM 1340 C CD1 . LEU A 1 203 ? -13.382 -12.914 -34.368 1.00 73.01  ? 401 LEU A CD1 1 
ATOM 1341 C CD2 . LEU A 1 203 ? -14.485 -11.063 -35.644 1.00 69.25  ? 401 LEU A CD2 1 
ATOM 1342 N N   . ASN A 1 204 ? -18.798 -13.603 -33.626 1.00 71.41  ? 402 ASN A N   1 
ATOM 1343 C CA  . ASN A 1 204 ? -19.920 -14.536 -33.602 1.00 74.18  ? 402 ASN A CA  1 
ATOM 1344 C C   . ASN A 1 204 ? -20.947 -14.018 -32.603 1.00 77.39  ? 402 ASN A C   1 
ATOM 1345 O O   . ASN A 1 204 ? -20.738 -14.105 -31.388 1.00 71.50  ? 402 ASN A O   1 
ATOM 1346 C CB  . ASN A 1 204 ? -19.454 -15.944 -33.236 1.00 79.45  ? 402 ASN A CB  1 
ATOM 1347 C CG  . ASN A 1 204 ? -20.026 -17.005 -34.156 1.00 87.01  ? 402 ASN A CG  1 
ATOM 1348 O OD1 . ASN A 1 204 ? -21.077 -16.812 -34.768 1.00 86.61  ? 402 ASN A OD1 1 
ATOM 1349 N ND2 . ASN A 1 204 ? -19.334 -18.134 -34.260 1.00 90.91  ? 402 ASN A ND2 1 
ATOM 1350 N N   . VAL A 1 205 ? -22.053 -13.484 -33.115 1.00 68.07  ? 403 VAL A N   1 
ATOM 1351 C CA  . VAL A 1 205 ? -23.077 -12.885 -32.264 1.00 62.20  ? 403 VAL A CA  1 
ATOM 1352 C C   . VAL A 1 205 ? -24.126 -13.907 -31.843 1.00 69.29  ? 403 VAL A C   1 
ATOM 1353 O O   . VAL A 1 205 ? -24.592 -13.888 -30.701 1.00 74.09  ? 403 VAL A O   1 
ATOM 1354 C CB  . VAL A 1 205 ? -23.718 -11.684 -32.989 1.00 65.06  ? 403 VAL A CB  1 
ATOM 1355 C CG1 . VAL A 1 205 ? -24.862 -11.109 -32.168 1.00 69.13  ? 403 VAL A CG1 1 
ATOM 1356 C CG2 . VAL A 1 205 ? -22.671 -10.617 -33.271 1.00 67.49  ? 403 VAL A CG2 1 
ATOM 1357 N N   . LYS A 1 206 ? -24.503 -14.810 -32.750 1.00 62.56  ? 404 LYS A N   1 
ATOM 1358 C CA  . LYS A 1 206 ? -25.557 -15.779 -32.448 1.00 70.46  ? 404 LYS A CA  1 
ATOM 1359 C C   . LYS A 1 206 ? -25.261 -16.624 -31.213 1.00 68.69  ? 404 LYS A C   1 
ATOM 1360 O O   . LYS A 1 206 ? -26.127 -16.690 -30.324 1.00 65.42  ? 404 LYS A O   1 
ATOM 1361 C CB  . LYS A 1 206 ? -25.819 -16.654 -33.680 1.00 63.48  ? 404 LYS A CB  1 
ATOM 1362 C CG  . LYS A 1 206 ? -26.834 -17.767 -33.454 1.00 66.77  ? 404 LYS A CG  1 
ATOM 1363 C CD  . LYS A 1 206 ? -28.198 -17.214 -33.068 1.00 70.43  ? 404 LYS A CD  1 
ATOM 1364 C CE  . LYS A 1 206 ? -29.203 -18.335 -32.844 1.00 69.96  ? 404 LYS A CE  1 
ATOM 1365 N NZ  . LYS A 1 206 ? -30.537 -17.820 -32.430 1.00 70.83  ? 404 LYS A NZ  1 
ATOM 1366 N N   . PRO A 1 207 ? -24.098 -17.275 -31.074 1.00 69.40  ? 405 PRO A N   1 
ATOM 1367 C CA  . PRO A 1 207 ? -23.873 -18.074 -29.857 1.00 65.39  ? 405 PRO A CA  1 
ATOM 1368 C C   . PRO A 1 207 ? -23.835 -17.242 -28.588 1.00 69.71  ? 405 PRO A C   1 
ATOM 1369 O O   . PRO A 1 207 ? -24.133 -17.764 -27.506 1.00 58.53  ? 405 PRO A O   1 
ATOM 1370 C CB  . PRO A 1 207 ? -22.525 -18.756 -30.130 1.00 64.16  ? 405 PRO A CB  1 
ATOM 1371 C CG  . PRO A 1 207 ? -21.842 -17.856 -31.089 1.00 67.15  ? 405 PRO A CG  1 
ATOM 1372 C CD  . PRO A 1 207 ? -22.929 -17.324 -31.972 1.00 64.05  ? 405 PRO A CD  1 
ATOM 1373 N N   . ILE A 1 208 ? -23.476 -15.960 -28.686 1.00 67.26  ? 406 ILE A N   1 
ATOM 1374 C CA  . ILE A 1 208 ? -23.515 -15.090 -27.516 1.00 60.06  ? 406 ILE A CA  1 
ATOM 1375 C C   . ILE A 1 208 ? -24.954 -14.851 -27.078 1.00 65.29  ? 406 ILE A C   1 
ATOM 1376 O O   . ILE A 1 208 ? -25.267 -14.882 -25.881 1.00 57.29  ? 406 ILE A O   1 
ATOM 1377 C CB  . ILE A 1 208 ? -22.784 -13.767 -27.811 1.00 55.59  ? 406 ILE A CB  1 
ATOM 1378 C CG1 . ILE A 1 208 ? -21.299 -14.022 -28.073 1.00 58.13  ? 406 ILE A CG1 1 
ATOM 1379 C CG2 . ILE A 1 208 ? -22.967 -12.783 -26.663 1.00 63.78  ? 406 ILE A CG2 1 
ATOM 1380 C CD1 . ILE A 1 208 ? -20.502 -12.763 -28.344 1.00 61.13  ? 406 ILE A CD1 1 
ATOM 1381 N N   . GLU A 1 209 ? -25.853 -14.619 -28.037 1.00 56.76  ? 407 GLU A N   1 
ATOM 1382 C CA  . GLU A 1 209 ? -27.246 -14.351 -27.696 1.00 50.60  ? 407 GLU A CA  1 
ATOM 1383 C C   . GLU A 1 209 ? -27.947 -15.594 -27.165 1.00 61.90  ? 407 GLU A C   1 
ATOM 1384 O O   . GLU A 1 209 ? -28.853 -15.480 -26.331 1.00 59.99  ? 407 GLU A O   1 
ATOM 1385 C CB  . GLU A 1 209 ? -27.988 -13.799 -28.913 1.00 57.32  ? 407 GLU A CB  1 
ATOM 1386 C CG  . GLU A 1 209 ? -27.323 -12.584 -29.543 1.00 61.77  ? 407 GLU A CG  1 
ATOM 1387 C CD  . GLU A 1 209 ? -28.086 -12.054 -30.741 1.00 76.85  ? 407 GLU A CD  1 
ATOM 1388 O OE1 . GLU A 1 209 ? -28.623 -10.929 -30.657 1.00 70.07  ? 407 GLU A OE1 1 
ATOM 1389 O OE2 . GLU A 1 209 ? -28.154 -12.764 -31.765 1.00 69.01  ? 407 GLU A OE2 1 
ATOM 1390 N N   . ASP A 1 210 ? -27.551 -16.785 -27.628 1.00 59.12  ? 408 ASP A N   1 
ATOM 1391 C CA  . ASP A 1 210 ? -28.156 -18.009 -27.110 1.00 61.18  ? 408 ASP A CA  1 
ATOM 1392 C C   . ASP A 1 210 ? -27.845 -18.202 -25.632 1.00 55.90  ? 408 ASP A C   1 
ATOM 1393 O O   . ASP A 1 210 ? -28.672 -18.743 -24.889 1.00 53.80  ? 408 ASP A O   1 
ATOM 1394 C CB  . ASP A 1 210 ? -27.682 -19.223 -27.909 1.00 67.84  ? 408 ASP A CB  1 
ATOM 1395 C CG  . ASP A 1 210 ? -28.183 -19.215 -29.339 1.00 72.63  ? 408 ASP A CG  1 
ATOM 1396 O OD1 . ASP A 1 210 ? -27.348 -19.125 -30.263 1.00 79.80  ? 408 ASP A OD1 1 
ATOM 1397 O OD2 . ASP A 1 210 ? -29.413 -19.292 -29.540 1.00 71.16  ? 408 ASP A OD2 1 
ATOM 1398 N N   . ILE A 1 211 ? -26.663 -17.771 -25.189 1.00 52.59  ? 409 ILE A N   1 
ATOM 1399 C CA  . ILE A 1 211 ? -26.330 -17.857 -23.772 1.00 58.43  ? 409 ILE A CA  1 
ATOM 1400 C C   . ILE A 1 211 ? -27.098 -16.806 -22.981 1.00 54.89  ? 409 ILE A C   1 
ATOM 1401 O O   . ILE A 1 211 ? -27.603 -17.081 -21.886 1.00 51.34  ? 409 ILE A O   1 
ATOM 1402 C CB  . ILE A 1 211 ? -24.810 -17.721 -23.571 1.00 53.70  ? 409 ILE A CB  1 
ATOM 1403 C CG1 . ILE A 1 211 ? -24.069 -18.793 -24.373 1.00 44.80  ? 409 ILE A CG1 1 
ATOM 1404 C CG2 . ILE A 1 211 ? -24.454 -17.819 -22.095 1.00 40.88  ? 409 ILE A CG2 1 
ATOM 1405 C CD1 . ILE A 1 211 ? -22.563 -18.706 -24.264 1.00 55.55  ? 409 ILE A CD1 1 
ATOM 1406 N N   . GLN A 1 212 ? -27.207 -15.590 -23.524 1.00 53.40  ? 410 GLN A N   1 
ATOM 1407 C CA  . GLN A 1 212 ? -27.939 -14.535 -22.831 1.00 50.60  ? 410 GLN A CA  1 
ATOM 1408 C C   . GLN A 1 212 ? -29.419 -14.876 -22.713 1.00 52.35  ? 410 GLN A C   1 
ATOM 1409 O O   . GLN A 1 212 ? -30.048 -14.580 -21.690 1.00 55.33  ? 410 GLN A O   1 
ATOM 1410 C CB  . GLN A 1 212 ? -27.756 -13.200 -23.550 1.00 50.69  ? 410 GLN A CB  1 
ATOM 1411 C CG  . GLN A 1 212 ? -28.298 -12.009 -22.773 1.00 47.10  ? 410 GLN A CG  1 
ATOM 1412 C CD  . GLN A 1 212 ? -28.353 -10.743 -23.603 1.00 48.81  ? 410 GLN A CD  1 
ATOM 1413 O OE1 . GLN A 1 212 ? -27.932 -9.676  -23.156 1.00 54.75  ? 410 GLN A OE1 1 
ATOM 1414 N NE2 . GLN A 1 212 ? -28.883 -10.852 -24.815 1.00 46.61  ? 410 GLN A NE2 1 
ATOM 1415 N N   . ASP A 1 213 ? -29.994 -15.492 -23.750 1.00 48.12  ? 411 ASP A N   1 
ATOM 1416 C CA  . ASP A 1 213 ? -31.379 -15.944 -23.662 1.00 54.76  ? 411 ASP A CA  1 
ATOM 1417 C C   . ASP A 1 213 ? -31.556 -16.937 -22.522 1.00 55.08  ? 411 ASP A C   1 
ATOM 1418 O O   . ASP A 1 213 ? -32.578 -16.920 -21.825 1.00 51.73  ? 411 ASP A O   1 
ATOM 1419 C CB  . ASP A 1 213 ? -31.819 -16.569 -24.987 1.00 59.10  ? 411 ASP A CB  1 
ATOM 1420 C CG  . ASP A 1 213 ? -31.855 -15.566 -26.123 1.00 64.73  ? 411 ASP A CG  1 
ATOM 1421 O OD1 . ASP A 1 213 ? -31.504 -14.389 -25.893 1.00 64.14  ? 411 ASP A OD1 1 
ATOM 1422 O OD2 . ASP A 1 213 ? -32.234 -15.956 -27.247 1.00 76.28  ? 411 ASP A OD2 1 
ATOM 1423 N N   . ASN A 1 214 ? -30.567 -17.808 -22.313 1.00 54.69  ? 412 ASN A N   1 
ATOM 1424 C CA  . ASN A 1 214 ? -30.619 -18.729 -21.184 1.00 50.54  ? 412 ASN A CA  1 
ATOM 1425 C C   . ASN A 1 214 ? -30.431 -17.989 -19.865 1.00 52.22  ? 412 ASN A C   1 
ATOM 1426 O O   . ASN A 1 214 ? -31.067 -18.327 -18.860 1.00 46.37  ? 412 ASN A O   1 
ATOM 1427 C CB  . ASN A 1 214 ? -29.560 -19.818 -21.351 1.00 57.67  ? 412 ASN A CB  1 
ATOM 1428 C CG  . ASN A 1 214 ? -29.716 -20.943 -20.349 1.00 58.83  ? 412 ASN A CG  1 
ATOM 1429 O OD1 . ASN A 1 214 ? -30.805 -21.176 -19.825 1.00 74.18  ? 412 ASN A OD1 1 
ATOM 1430 N ND2 . ASN A 1 214 ? -28.625 -21.650 -20.077 1.00 66.58  ? 412 ASN A ND2 1 
ATOM 1431 N N   . LEU A 1 215 ? -29.565 -16.972 -19.853 1.00 49.53  ? 413 LEU A N   1 
ATOM 1432 C CA  . LEU A 1 215 ? -29.366 -16.182 -18.642 1.00 39.74  ? 413 LEU A CA  1 
ATOM 1433 C C   . LEU A 1 215 ? -30.584 -15.319 -18.338 1.00 45.75  ? 413 LEU A C   1 
ATOM 1434 O O   . LEU A 1 215 ? -30.950 -15.142 -17.170 1.00 44.68  ? 413 LEU A O   1 
ATOM 1435 C CB  . LEU A 1 215 ? -28.116 -15.313 -18.782 1.00 43.48  ? 413 LEU A CB  1 
ATOM 1436 C CG  . LEU A 1 215 ? -26.781 -16.050 -18.902 1.00 43.90  ? 413 LEU A CG  1 
ATOM 1437 C CD1 . LEU A 1 215 ? -25.657 -15.071 -19.192 1.00 48.97  ? 413 LEU A CD1 1 
ATOM 1438 C CD2 . LEU A 1 215 ? -26.492 -16.841 -17.637 1.00 52.60  ? 413 LEU A CD2 1 
ATOM 1439 N N   . LEU A 1 216 ? -31.222 -14.769 -19.375 1.00 50.15  ? 414 LEU A N   1 
ATOM 1440 C CA  . LEU A 1 216 ? -32.413 -13.953 -19.163 1.00 42.02  ? 414 LEU A CA  1 
ATOM 1441 C C   . LEU A 1 216 ? -33.558 -14.784 -18.598 1.00 44.47  ? 414 LEU A C   1 
ATOM 1442 O O   . LEU A 1 216 ? -34.327 -14.304 -17.756 1.00 40.23  ? 414 LEU A O   1 
ATOM 1443 C CB  . LEU A 1 216 ? -32.828 -13.282 -20.472 1.00 37.55  ? 414 LEU A CB  1 
ATOM 1444 C CG  . LEU A 1 216 ? -31.989 -12.081 -20.909 1.00 44.04  ? 414 LEU A CG  1 
ATOM 1445 C CD1 . LEU A 1 216 ? -32.273 -11.724 -22.358 1.00 41.98  ? 414 LEU A CD1 1 
ATOM 1446 C CD2 . LEU A 1 216 ? -32.263 -10.892 -20.003 1.00 38.62  ? 414 LEU A CD2 1 
ATOM 1447 N N   . GLN A 1 217 ? -33.690 -16.033 -19.052 1.00 44.75  ? 415 GLN A N   1 
ATOM 1448 C CA  . GLN A 1 217 ? -34.713 -16.916 -18.498 1.00 46.99  ? 415 GLN A CA  1 
ATOM 1449 C C   . GLN A 1 217 ? -34.484 -17.157 -17.012 1.00 40.87  ? 415 GLN A C   1 
ATOM 1450 O O   . GLN A 1 217 ? -35.431 -17.124 -16.217 1.00 39.73  ? 415 GLN A O   1 
ATOM 1451 C CB  . GLN A 1 217 ? -34.731 -18.245 -19.254 1.00 45.07  ? 415 GLN A CB  1 
ATOM 1452 C CG  . GLN A 1 217 ? -35.349 -18.176 -20.639 1.00 56.35  ? 415 GLN A CG  1 
ATOM 1453 C CD  . GLN A 1 217 ? -35.368 -19.526 -21.329 1.00 64.60  ? 415 GLN A CD  1 
ATOM 1454 O OE1 . GLN A 1 217 ? -34.622 -20.434 -20.960 1.00 58.35  ? 415 GLN A OE1 1 
ATOM 1455 N NE2 . GLN A 1 217 ? -36.226 -19.667 -22.332 1.00 77.84  ? 415 GLN A NE2 1 
ATOM 1456 N N   . ALA A 1 218 ? -33.233 -17.401 -16.619 1.00 39.36  ? 416 ALA A N   1 
ATOM 1457 C CA  . ALA A 1 218 ? -32.936 -17.643 -15.211 1.00 39.60  ? 416 ALA A CA  1 
ATOM 1458 C C   . ALA A 1 218 ? -33.113 -16.376 -14.383 1.00 34.81  ? 416 ALA A C   1 
ATOM 1459 O O   . ALA A 1 218 ? -33.565 -16.438 -13.234 1.00 40.61  ? 416 ALA A O   1 
ATOM 1460 C CB  . ALA A 1 218 ? -31.519 -18.192 -15.060 1.00 30.66  ? 416 ALA A CB  1 
ATOM 1461 N N   . LEU A 1 219 ? -32.765 -15.218 -14.948 1.00 39.94  ? 417 LEU A N   1 
ATOM 1462 C CA  . LEU A 1 219 ? -32.934 -13.964 -14.220 1.00 34.80  ? 417 LEU A CA  1 
ATOM 1463 C C   . LEU A 1 219 ? -34.408 -13.636 -14.021 1.00 37.03  ? 417 LEU A C   1 
ATOM 1464 O O   . LEU A 1 219 ? -34.799 -13.135 -12.960 1.00 41.94  ? 417 LEU A O   1 
ATOM 1465 C CB  . LEU A 1 219 ? -32.226 -12.827 -14.956 1.00 35.86  ? 417 LEU A CB  1 
ATOM 1466 C CG  . LEU A 1 219 ? -32.333 -11.441 -14.316 1.00 40.18  ? 417 LEU A CG  1 
ATOM 1467 C CD1 . LEU A 1 219 ? -31.754 -11.450 -12.909 1.00 37.26  ? 417 LEU A CD1 1 
ATOM 1468 C CD2 . LEU A 1 219 ? -31.643 -10.393 -15.176 1.00 37.37  ? 417 LEU A CD2 1 
ATOM 1469 N N   . GLU A 1 220 ? -35.242 -13.912 -15.026 1.00 39.39  ? 418 GLU A N   1 
ATOM 1470 C CA  . GLU A 1 220 ? -36.673 -13.659 -14.892 1.00 44.92  ? 418 GLU A CA  1 
ATOM 1471 C C   . GLU A 1 220 ? -37.278 -14.522 -13.792 1.00 41.00  ? 418 GLU A C   1 
ATOM 1472 O O   . GLU A 1 220 ? -38.056 -14.038 -12.962 1.00 46.13  ? 418 GLU A O   1 
ATOM 1473 C CB  . GLU A 1 220 ? -37.380 -13.917 -16.223 1.00 45.76  ? 418 GLU A CB  1 
ATOM 1474 C CG  . GLU A 1 220 ? -38.859 -13.560 -16.215 1.00 49.90  ? 418 GLU A CG  1 
ATOM 1475 C CD  . GLU A 1 220 ? -39.612 -14.156 -17.390 1.00 58.13  ? 418 GLU A CD  1 
ATOM 1476 O OE1 . GLU A 1 220 ? -40.569 -14.924 -17.157 1.00 74.09  ? 418 GLU A OE1 1 
ATOM 1477 O OE2 . GLU A 1 220 ? -39.241 -13.863 -18.546 1.00 65.57  ? 418 GLU A OE2 1 
ATOM 1478 N N   . LEU A 1 221 ? -36.926 -15.810 -13.771 1.00 41.72  ? 419 LEU A N   1 
ATOM 1479 C CA  . LEU A 1 221 ? -37.453 -16.706 -12.748 1.00 40.11  ? 419 LEU A CA  1 
ATOM 1480 C C   . LEU A 1 221 ? -36.916 -16.348 -11.368 1.00 41.91  ? 419 LEU A C   1 
ATOM 1481 O O   . LEU A 1 221 ? -37.652 -16.403 -10.376 1.00 40.48  ? 419 LEU A O   1 
ATOM 1482 C CB  . LEU A 1 221 ? -37.112 -18.154 -13.098 1.00 44.58  ? 419 LEU A CB  1 
ATOM 1483 C CG  . LEU A 1 221 ? -37.600 -19.214 -12.112 1.00 48.54  ? 419 LEU A CG  1 
ATOM 1484 C CD1 . LEU A 1 221 ? -39.104 -19.112 -11.942 1.00 36.44  ? 419 LEU A CD1 1 
ATOM 1485 C CD2 . LEU A 1 221 ? -37.202 -20.606 -12.575 1.00 48.83  ? 419 LEU A CD2 1 
ATOM 1486 N N   . GLN A 1 222 ? -35.636 -15.977 -11.288 1.00 42.20  ? 420 GLN A N   1 
ATOM 1487 C CA  . GLN A 1 222 ? -35.048 -15.600 -10.006 1.00 40.16  ? 420 GLN A CA  1 
ATOM 1488 C C   . GLN A 1 222 ? -35.761 -14.397 -9.401  1.00 39.93  ? 420 GLN A C   1 
ATOM 1489 O O   . GLN A 1 222 ? -36.008 -14.356 -8.190  1.00 46.16  ? 420 GLN A O   1 
ATOM 1490 C CB  . GLN A 1 222 ? -33.557 -15.311 -10.186 1.00 43.45  ? 420 GLN A CB  1 
ATOM 1491 C CG  . GLN A 1 222 ? -32.907 -14.565 -9.032  1.00 43.59  ? 420 GLN A CG  1 
ATOM 1492 C CD  . GLN A 1 222 ? -32.789 -15.403 -7.776  1.00 36.22  ? 420 GLN A CD  1 
ATOM 1493 O OE1 . GLN A 1 222 ? -32.835 -16.632 -7.827  1.00 49.42  ? 420 GLN A OE1 1 
ATOM 1494 N NE2 . GLN A 1 222 ? -32.636 -14.740 -6.636  1.00 44.35  ? 420 GLN A NE2 1 
ATOM 1495 N N   . LEU A 1 223 ? -36.112 -13.411 -10.229 1.00 53.08  ? 421 LEU A N   1 
ATOM 1496 C CA  . LEU A 1 223 ? -36.765 -12.213 -9.714  1.00 38.12  ? 421 LEU A CA  1 
ATOM 1497 C C   . LEU A 1 223 ? -38.215 -12.478 -9.326  1.00 45.88  ? 421 LEU A C   1 
ATOM 1498 O O   . LEU A 1 223 ? -38.726 -11.854 -8.389  1.00 50.39  ? 421 LEU A O   1 
ATOM 1499 C CB  . LEU A 1 223 ? -36.683 -11.091 -10.748 1.00 39.33  ? 421 LEU A CB  1 
ATOM 1500 C CG  . LEU A 1 223 ? -35.269 -10.596 -11.058 1.00 34.28  ? 421 LEU A CG  1 
ATOM 1501 C CD1 . LEU A 1 223 ? -35.284 -9.634  -12.232 1.00 37.48  ? 421 LEU A CD1 1 
ATOM 1502 C CD2 . LEU A 1 223 ? -34.646 -9.942  -9.833  1.00 36.85  ? 421 LEU A CD2 1 
ATOM 1503 N N   . LYS A 1 224 ? -38.893 -13.392 -10.026 1.00 42.12  ? 422 LYS A N   1 
ATOM 1504 C CA  . LYS A 1 224 ? -40.275 -13.703 -9.677  1.00 38.65  ? 422 LYS A CA  1 
ATOM 1505 C C   . LYS A 1 224 ? -40.361 -14.494 -8.378  1.00 49.92  ? 422 LYS A C   1 
ATOM 1506 O O   . LYS A 1 224 ? -41.315 -14.321 -7.610  1.00 49.83  ? 422 LYS A O   1 
ATOM 1507 C CB  . LYS A 1 224 ? -40.951 -14.472 -10.814 1.00 49.15  ? 422 LYS A CB  1 
ATOM 1508 C CG  . LYS A 1 224 ? -41.174 -13.651 -12.072 1.00 53.30  ? 422 LYS A CG  1 
ATOM 1509 C CD  . LYS A 1 224 ? -41.955 -14.437 -13.114 1.00 50.92  ? 422 LYS A CD  1 
ATOM 1510 C CE  . LYS A 1 224 ? -42.220 -13.599 -14.354 1.00 65.55  ? 422 LYS A CE  1 
ATOM 1511 N NZ  . LYS A 1 224 ? -43.005 -12.373 -14.038 1.00 79.11  ? 422 LYS A NZ  1 
ATOM 1512 N N   . LEU A 1 225 ? -39.382 -15.361 -8.113  1.00 49.48  ? 423 LEU A N   1 
ATOM 1513 C CA  . LEU A 1 225 ? -39.398 -16.143 -6.882  1.00 42.08  ? 423 LEU A CA  1 
ATOM 1514 C C   . LEU A 1 225 ? -38.887 -15.348 -5.688  1.00 47.68  ? 423 LEU A C   1 
ATOM 1515 O O   . LEU A 1 225 ? -39.351 -15.562 -4.563  1.00 54.25  ? 423 LEU A O   1 
ATOM 1516 C CB  . LEU A 1 225 ? -38.560 -17.412 -7.052  1.00 43.53  ? 423 LEU A CB  1 
ATOM 1517 C CG  . LEU A 1 225 ? -39.003 -18.414 -8.119  1.00 49.04  ? 423 LEU A CG  1 
ATOM 1518 C CD1 . LEU A 1 225 ? -38.047 -19.599 -8.173  1.00 45.91  ? 423 LEU A CD1 1 
ATOM 1519 C CD2 . LEU A 1 225 ? -40.425 -18.882 -7.861  1.00 46.22  ? 423 LEU A CD2 1 
ATOM 1520 N N   . ASN A 1 226 ? -37.943 -14.434 -5.908  1.00 49.65  ? 424 ASN A N   1 
ATOM 1521 C CA  . ASN A 1 226 ? -37.305 -13.716 -4.813  1.00 39.76  ? 424 ASN A CA  1 
ATOM 1522 C C   . ASN A 1 226 ? -37.973 -12.386 -4.493  1.00 45.56  ? 424 ASN A C   1 
ATOM 1523 O O   . ASN A 1 226 ? -37.731 -11.833 -3.415  1.00 45.68  ? 424 ASN A O   1 
ATOM 1524 C CB  . ASN A 1 226 ? -35.826 -13.477 -5.136  1.00 37.99  ? 424 ASN A CB  1 
ATOM 1525 C CG  . ASN A 1 226 ? -35.009 -13.119 -3.910  1.00 44.90  ? 424 ASN A CG  1 
ATOM 1526 O OD1 . ASN A 1 226 ? -35.376 -13.457 -2.785  1.00 61.50  ? 424 ASN A OD1 1 
ATOM 1527 N ND2 . ASN A 1 226 ? -33.891 -12.435 -4.123  1.00 42.66  ? 424 ASN A ND2 1 
ATOM 1528 N N   . HIS A 1 227 ? -38.807 -11.861 -5.390  1.00 49.13  ? 425 HIS A N   1 
ATOM 1529 C CA  . HIS A 1 227 ? -39.446 -10.557 -5.211  1.00 45.18  ? 425 HIS A CA  1 
ATOM 1530 C C   . HIS A 1 227 ? -40.936 -10.681 -5.498  1.00 50.87  ? 425 HIS A C   1 
ATOM 1531 O O   . HIS A 1 227 ? -41.397 -10.381 -6.608  1.00 48.44  ? 425 HIS A O   1 
ATOM 1532 C CB  . HIS A 1 227 ? -38.796 -9.500  -6.104  1.00 47.39  ? 425 HIS A CB  1 
ATOM 1533 C CG  . HIS A 1 227 ? -37.344 -9.282  -5.815  1.00 45.68  ? 425 HIS A CG  1 
ATOM 1534 N ND1 . HIS A 1 227 ? -36.902 -8.404  -4.850  1.00 43.83  ? 425 HIS A ND1 1 
ATOM 1535 C CD2 . HIS A 1 227 ? -36.234 -9.830  -6.362  1.00 48.33  ? 425 HIS A CD2 1 
ATOM 1536 C CE1 . HIS A 1 227 ? -35.581 -8.419  -4.815  1.00 44.78  ? 425 HIS A CE1 1 
ATOM 1537 N NE2 . HIS A 1 227 ? -35.151 -9.276  -5.724  1.00 43.43  ? 425 HIS A NE2 1 
ATOM 1538 N N   . PRO A 1 228 ? -41.725 -11.116 -4.511  1.00 49.44  ? 426 PRO A N   1 
ATOM 1539 C CA  . PRO A 1 228 ? -43.179 -11.204 -4.710  1.00 46.94  ? 426 PRO A CA  1 
ATOM 1540 C C   . PRO A 1 228 ? -43.884 -9.859  -4.682  1.00 52.65  ? 426 PRO A C   1 
ATOM 1541 O O   . PRO A 1 228 ? -45.093 -9.810  -4.947  1.00 69.68  ? 426 PRO A O   1 
ATOM 1542 C CB  . PRO A 1 228 ? -43.635 -12.083 -3.541  1.00 53.88  ? 426 PRO A CB  1 
ATOM 1543 C CG  . PRO A 1 228 ? -42.631 -11.808 -2.471  1.00 50.91  ? 426 PRO A CG  1 
ATOM 1544 C CD  . PRO A 1 228 ? -41.318 -11.594 -3.178  1.00 46.72  ? 426 PRO A CD  1 
ATOM 1545 N N   . GLU A 1 229 ? -43.175 -8.772  -4.375  1.00 56.11  ? 427 GLU A N   1 
ATOM 1546 C CA  . GLU A 1 229 ? -43.792 -7.468  -4.182  1.00 59.74  ? 427 GLU A CA  1 
ATOM 1547 C C   . GLU A 1 229 ? -43.525 -6.481  -5.308  1.00 64.79  ? 427 GLU A C   1 
ATOM 1548 O O   . GLU A 1 229 ? -44.259 -5.495  -5.423  1.00 53.53  ? 427 GLU A O   1 
ATOM 1549 C CB  . GLU A 1 229 ? -43.315 -6.844  -2.861  1.00 58.63  ? 427 GLU A CB  1 
ATOM 1550 C CG  . GLU A 1 229 ? -41.914 -6.232  -2.910  1.00 70.08  ? 427 GLU A CG  1 
ATOM 1551 C CD  . GLU A 1 229 ? -40.835 -7.233  -3.284  1.00 62.65  ? 427 GLU A CD  1 
ATOM 1552 O OE1 . GLU A 1 229 ? -39.923 -6.868  -4.057  1.00 68.59  ? 427 GLU A OE1 1 
ATOM 1553 O OE2 . GLU A 1 229 ? -40.901 -8.388  -2.812  1.00 65.49  ? 427 GLU A OE2 1 
ATOM 1554 N N   . SER A 1 230 ? -42.508 -6.713  -6.132  1.00 59.04  ? 428 SER A N   1 
ATOM 1555 C CA  . SER A 1 230 ? -42.110 -5.773  -7.173  1.00 58.22  ? 428 SER A CA  1 
ATOM 1556 C C   . SER A 1 230 ? -42.745 -6.195  -8.492  1.00 68.98  ? 428 SER A C   1 
ATOM 1557 O O   . SER A 1 230 ? -42.356 -7.209  -9.082  1.00 55.27  ? 428 SER A O   1 
ATOM 1558 C CB  . SER A 1 230 ? -40.589 -5.706  -7.291  1.00 67.36  ? 428 SER A CB  1 
ATOM 1559 O OG  . SER A 1 230 ? -40.196 -4.691  -8.200  1.00 75.67  ? 428 SER A OG  1 
ATOM 1560 N N   . SER A 1 231 ? -43.721 -5.416  -8.953  1.00 72.35  ? 429 SER A N   1 
ATOM 1561 C CA  . SER A 1 231 ? -44.357 -5.681  -10.236 1.00 78.87  ? 429 SER A CA  1 
ATOM 1562 C C   . SER A 1 231 ? -43.412 -5.296  -11.367 1.00 75.19  ? 429 SER A C   1 
ATOM 1563 O O   . SER A 1 231 ? -42.928 -4.160  -11.420 1.00 70.14  ? 429 SER A O   1 
ATOM 1564 C CB  . SER A 1 231 ? -45.670 -4.909  -10.346 1.00 80.02  ? 429 SER A CB  1 
ATOM 1565 O OG  . SER A 1 231 ? -46.579 -5.298  -9.332  1.00 84.25  ? 429 SER A OG  1 
ATOM 1566 N N   . GLN A 1 232 ? -43.145 -6.248  -12.263 1.00 53.15  ? 430 GLN A N   1 
ATOM 1567 C CA  . GLN A 1 232 ? -42.304 -6.020  -13.440 1.00 41.04  ? 430 GLN A CA  1 
ATOM 1568 C C   . GLN A 1 232 ? -40.895 -5.577  -13.051 1.00 39.73  ? 430 GLN A C   1 
ATOM 1569 O O   . GLN A 1 232 ? -40.301 -4.705  -13.689 1.00 52.45  ? 430 GLN A O   1 
ATOM 1570 C CB  . GLN A 1 232 ? -42.948 -5.010  -14.393 1.00 46.19  ? 430 GLN A CB  1 
ATOM 1571 C CG  . GLN A 1 232 ? -44.218 -5.513  -15.059 1.00 47.33  ? 430 GLN A CG  1 
ATOM 1572 C CD  . GLN A 1 232 ? -43.962 -6.684  -15.987 1.00 45.58  ? 430 GLN A CD  1 
ATOM 1573 O OE1 . GLN A 1 232 ? -42.879 -6.812  -16.558 1.00 52.50  ? 430 GLN A OE1 1 
ATOM 1574 N NE2 . GLN A 1 232 ? -44.958 -7.548  -16.139 1.00 61.29  ? 430 GLN A NE2 1 
ATOM 1575 N N   . LEU A 1 233 ? -40.352 -6.183  -11.992 1.00 51.97  ? 431 LEU A N   1 
ATOM 1576 C CA  . LEU A 1 233 ? -38.968 -5.906  -11.621 1.00 46.50  ? 431 LEU A CA  1 
ATOM 1577 C C   . LEU A 1 233 ? -38.004 -6.381  -12.698 1.00 45.52  ? 431 LEU A C   1 
ATOM 1578 O O   . LEU A 1 233 ? -36.938 -5.782  -12.888 1.00 41.97  ? 431 LEU A O   1 
ATOM 1579 C CB  . LEU A 1 233 ? -38.637 -6.565  -10.283 1.00 56.15  ? 431 LEU A CB  1 
ATOM 1580 C CG  . LEU A 1 233 ? -37.243 -6.284  -9.716  1.00 50.90  ? 431 LEU A CG  1 
ATOM 1581 C CD1 . LEU A 1 233 ? -37.058 -4.799  -9.445  1.00 54.05  ? 431 LEU A CD1 1 
ATOM 1582 C CD2 . LEU A 1 233 ? -37.004 -7.095  -8.456  1.00 53.41  ? 431 LEU A CD2 1 
ATOM 1583 N N   . PHE A 1 234 ? -38.361 -7.453  -13.410 1.00 41.26  ? 432 PHE A N   1 
ATOM 1584 C CA  . PHE A 1 234 ? -37.540 -7.920  -14.521 1.00 41.83  ? 432 PHE A CA  1 
ATOM 1585 C C   . PHE A 1 234 ? -37.438 -6.858  -15.609 1.00 43.40  ? 432 PHE A C   1 
ATOM 1586 O O   . PHE A 1 234 ? -36.356 -6.622  -16.159 1.00 43.96  ? 432 PHE A O   1 
ATOM 1587 C CB  . PHE A 1 234 ? -38.122 -9.221  -15.077 1.00 32.33  ? 432 PHE A CB  1 
ATOM 1588 C CG  . PHE A 1 234 ? -37.328 -9.815  -16.204 1.00 44.38  ? 432 PHE A CG  1 
ATOM 1589 C CD1 . PHE A 1 234 ? -36.007 -10.184 -16.019 1.00 43.53  ? 432 PHE A CD1 1 
ATOM 1590 C CD2 . PHE A 1 234 ? -37.911 -10.027 -17.442 1.00 49.49  ? 432 PHE A CD2 1 
ATOM 1591 C CE1 . PHE A 1 234 ? -35.276 -10.738 -17.053 1.00 38.50  ? 432 PHE A CE1 1 
ATOM 1592 C CE2 . PHE A 1 234 ? -37.187 -10.582 -18.480 1.00 41.00  ? 432 PHE A CE2 1 
ATOM 1593 C CZ  . PHE A 1 234 ? -35.867 -10.938 -18.285 1.00 43.69  ? 432 PHE A CZ  1 
ATOM 1594 N N   . ALA A 1 235 ? -38.554 -6.197  -15.921 1.00 47.92  ? 433 ALA A N   1 
ATOM 1595 C CA  . ALA A 1 235 ? -38.528 -5.128  -16.913 1.00 42.62  ? 433 ALA A CA  1 
ATOM 1596 C C   . ALA A 1 235 ? -37.741 -3.924  -16.408 1.00 48.38  ? 433 ALA A C   1 
ATOM 1597 O O   . ALA A 1 235 ? -37.061 -3.249  -17.190 1.00 53.95  ? 433 ALA A O   1 
ATOM 1598 C CB  . ALA A 1 235 ? -39.953 -4.720  -17.282 1.00 39.79  ? 433 ALA A CB  1 
ATOM 1599 N N   . LYS A 1 236 ? -37.819 -3.641  -15.105 1.00 44.76  ? 434 LYS A N   1 
ATOM 1600 C CA  . LYS A 1 236 ? -37.100 -2.497  -14.554 1.00 41.74  ? 434 LYS A CA  1 
ATOM 1601 C C   . LYS A 1 236 ? -35.594 -2.732  -14.543 1.00 42.56  ? 434 LYS A C   1 
ATOM 1602 O O   . LYS A 1 236 ? -34.819 -1.787  -14.732 1.00 49.88  ? 434 LYS A O   1 
ATOM 1603 C CB  . LYS A 1 236 ? -37.601 -2.191  -13.142 1.00 42.71  ? 434 LYS A CB  1 
ATOM 1604 C CG  . LYS A 1 236 ? -39.052 -1.736  -13.080 1.00 53.08  ? 434 LYS A CG  1 
ATOM 1605 C CD  . LYS A 1 236 ? -39.469 -1.417  -11.653 1.00 59.98  ? 434 LYS A CD  1 
ATOM 1606 C CE  . LYS A 1 236 ? -40.919 -0.966  -11.590 1.00 66.96  ? 434 LYS A CE  1 
ATOM 1607 N NZ  . LYS A 1 236 ? -41.338 -0.644  -10.197 1.00 84.18  ? 434 LYS A NZ  1 
ATOM 1608 N N   . LEU A 1 237 ? -35.161 -3.977  -14.324 1.00 46.04  ? 435 LEU A N   1 
ATOM 1609 C CA  . LEU A 1 237 ? -33.731 -4.271  -14.326 1.00 50.47  ? 435 LEU A CA  1 
ATOM 1610 C C   . LEU A 1 237 ? -33.134 -4.106  -15.716 1.00 48.40  ? 435 LEU A C   1 
ATOM 1611 O O   . LEU A 1 237 ? -32.017 -3.595  -15.860 1.00 47.78  ? 435 LEU A O   1 
ATOM 1612 C CB  . LEU A 1 237 ? -33.484 -5.685  -13.803 1.00 42.76  ? 435 LEU A CB  1 
ATOM 1613 C CG  . LEU A 1 237 ? -33.063 -5.779  -12.337 1.00 56.17  ? 435 LEU A CG  1 
ATOM 1614 C CD1 . LEU A 1 237 ? -32.585 -7.183  -12.007 1.00 51.44  ? 435 LEU A CD1 1 
ATOM 1615 C CD2 . LEU A 1 237 ? -31.980 -4.755  -12.045 1.00 61.24  ? 435 LEU A CD2 1 
ATOM 1616 N N   . LEU A 1 238 ? -33.858 -4.538  -16.750 1.00 52.73  ? 436 LEU A N   1 
ATOM 1617 C CA  . LEU A 1 238 ? -33.368 -4.374  -18.113 1.00 47.87  ? 436 LEU A CA  1 
ATOM 1618 C C   . LEU A 1 238 ? -33.253 -2.903  -18.493 1.00 42.27  ? 436 LEU A C   1 
ATOM 1619 O O   . LEU A 1 238 ? -32.348 -2.529  -19.248 1.00 46.06  ? 436 LEU A O   1 
ATOM 1620 C CB  . LEU A 1 238 ? -34.287 -5.109  -19.088 1.00 43.18  ? 436 LEU A CB  1 
ATOM 1621 C CG  . LEU A 1 238 ? -34.451 -6.607  -18.818 1.00 47.80  ? 436 LEU A CG  1 
ATOM 1622 C CD1 . LEU A 1 238 ? -35.501 -7.206  -19.737 1.00 54.39  ? 436 LEU A CD1 1 
ATOM 1623 C CD2 . LEU A 1 238 ? -33.122 -7.330  -18.973 1.00 53.10  ? 436 LEU A CD2 1 
ATOM 1624 N N   . GLN A 1 239 ? -34.149 -2.057  -17.979 1.00 41.50  ? 437 GLN A N   1 
ATOM 1625 C CA  . GLN A 1 239 ? -34.050 -0.628  -18.245 1.00 48.20  ? 437 GLN A CA  1 
ATOM 1626 C C   . GLN A 1 239 ? -32.867 0.003   -17.525 1.00 52.99  ? 437 GLN A C   1 
ATOM 1627 O O   . GLN A 1 239 ? -32.372 1.047   -17.963 1.00 51.07  ? 437 GLN A O   1 
ATOM 1628 C CB  . GLN A 1 239 ? -35.348 0.074   -17.843 1.00 49.91  ? 437 GLN A CB  1 
ATOM 1629 C CG  . GLN A 1 239 ? -36.557 -0.331  -18.674 1.00 63.21  ? 437 GLN A CG  1 
ATOM 1630 C CD  . GLN A 1 239 ? -37.832 0.353   -18.222 1.00 71.05  ? 437 GLN A CD  1 
ATOM 1631 O OE1 . GLN A 1 239 ? -38.314 0.123   -17.113 1.00 77.76  ? 437 GLN A OE1 1 
ATOM 1632 N NE2 . GLN A 1 239 ? -38.386 1.200   -19.081 1.00 75.10  ? 437 GLN A NE2 1 
ATOM 1633 N N   . LYS A 1 240 ? -32.399 -0.609  -16.433 1.00 52.40  ? 438 LYS A N   1 
ATOM 1634 C CA  . LYS A 1 240 ? -31.213 -0.109  -15.750 1.00 47.25  ? 438 LYS A CA  1 
ATOM 1635 C C   . LYS A 1 240 ? -29.953 -0.289  -16.584 1.00 60.13  ? 438 LYS A C   1 
ATOM 1636 O O   . LYS A 1 240 ? -28.981 0.444   -16.377 1.00 51.85  ? 438 LYS A O   1 
ATOM 1637 C CB  . LYS A 1 240 ? -31.047 -0.806  -14.400 1.00 48.04  ? 438 LYS A CB  1 
ATOM 1638 C CG  . LYS A 1 240 ? -32.138 -0.483  -13.391 1.00 56.73  ? 438 LYS A CG  1 
ATOM 1639 C CD  . LYS A 1 240 ? -32.134 0.992   -13.019 1.00 49.19  ? 438 LYS A CD  1 
ATOM 1640 C CE  . LYS A 1 240 ? -33.220 1.307   -12.001 1.00 51.36  ? 438 LYS A CE  1 
ATOM 1641 N NZ  . LYS A 1 240 ? -33.221 2.743   -11.609 1.00 69.46  ? 438 LYS A NZ  1 
ATOM 1642 N N   . MET A 1 241 ? -29.945 -1.248  -17.514 1.00 65.57  ? 439 MET A N   1 
ATOM 1643 C CA  . MET A 1 241 ? -28.789 -1.418  -18.388 1.00 62.30  ? 439 MET A CA  1 
ATOM 1644 C C   . MET A 1 241 ? -28.613 -0.226  -19.317 1.00 55.76  ? 439 MET A C   1 
ATOM 1645 O O   . MET A 1 241 ? -27.478 0.145   -19.638 1.00 59.85  ? 439 MET A O   1 
ATOM 1646 C CB  . MET A 1 241 ? -28.924 -2.707  -19.198 1.00 57.48  ? 439 MET A CB  1 
ATOM 1647 C CG  . MET A 1 241 ? -28.986 -3.967  -18.352 1.00 61.08  ? 439 MET A CG  1 
ATOM 1648 S SD  . MET A 1 241 ? -29.096 -5.465  -19.348 1.00 95.89  ? 439 MET A SD  1 
ATOM 1649 C CE  . MET A 1 241 ? -29.221 -6.711  -18.069 1.00 58.97  ? 439 MET A CE  1 
ATOM 1650 N N   . THR A 1 242 ? -29.716 0.382   -19.762 1.00 60.76  ? 440 THR A N   1 
ATOM 1651 C CA  . THR A 1 242 ? -29.615 1.605   -20.551 1.00 62.38  ? 440 THR A CA  1 
ATOM 1652 C C   . THR A 1 242 ? -29.026 2.737   -19.722 1.00 67.43  ? 440 THR A C   1 
ATOM 1653 O O   . THR A 1 242 ? -28.255 3.558   -20.232 1.00 75.88  ? 440 THR A O   1 
ATOM 1654 C CB  . THR A 1 242 ? -30.990 1.997   -21.092 1.00 66.13  ? 440 THR A CB  1 
ATOM 1655 O OG1 . THR A 1 242 ? -31.579 0.878   -21.766 1.00 68.29  ? 440 THR A OG1 1 
ATOM 1656 C CG2 . THR A 1 242 ? -30.868 3.158   -22.067 1.00 70.21  ? 440 THR A CG2 1 
ATOM 1657 N N   . ASP A 1 243 ? -29.375 2.793   -18.434 1.00 68.05  ? 441 ASP A N   1 
ATOM 1658 C CA  . ASP A 1 243 ? -28.800 3.802   -17.553 1.00 62.35  ? 441 ASP A CA  1 
ATOM 1659 C C   . ASP A 1 243 ? -27.317 3.553   -17.310 1.00 68.65  ? 441 ASP A C   1 
ATOM 1660 O O   . ASP A 1 243 ? -26.554 4.507   -17.124 1.00 66.03  ? 441 ASP A O   1 
ATOM 1661 C CB  . ASP A 1 243 ? -29.558 3.830   -16.226 1.00 60.93  ? 441 ASP A CB  1 
ATOM 1662 C CG  . ASP A 1 243 ? -31.061 3.908   -16.415 1.00 62.46  ? 441 ASP A CG  1 
ATOM 1663 O OD1 . ASP A 1 243 ? -31.512 3.981   -17.578 1.00 66.95  ? 441 ASP A OD1 1 
ATOM 1664 O OD2 . ASP A 1 243 ? -31.791 3.892   -15.401 1.00 72.02  ? 441 ASP A OD2 1 
ATOM 1665 N N   . LEU A 1 244 ? -26.894 2.285   -17.308 1.00 65.17  ? 442 LEU A N   1 
ATOM 1666 C CA  . LEU A 1 244 ? -25.484 1.971   -17.097 1.00 62.29  ? 442 LEU A CA  1 
ATOM 1667 C C   . LEU A 1 244 ? -24.624 2.461   -18.254 1.00 58.08  ? 442 LEU A C   1 
ATOM 1668 O O   . LEU A 1 244 ? -23.534 3.003   -18.039 1.00 68.01  ? 442 LEU A O   1 
ATOM 1669 C CB  . LEU A 1 244 ? -25.304 0.466   -16.901 1.00 53.15  ? 442 LEU A CB  1 
ATOM 1670 C CG  . LEU A 1 244 ? -25.637 -0.096  -15.520 1.00 56.87  ? 442 LEU A CG  1 
ATOM 1671 C CD1 . LEU A 1 244 ? -25.642 -1.615  -15.552 1.00 45.16  ? 442 LEU A CD1 1 
ATOM 1672 C CD2 . LEU A 1 244 ? -24.639 0.416   -14.496 1.00 49.46  ? 442 LEU A CD2 1 
ATOM 1673 N N   . ARG A 1 245 ? -25.095 2.276   -19.490 1.00 60.07  ? 443 ARG A N   1 
ATOM 1674 C CA  . ARG A 1 245 ? -24.329 2.731   -20.645 1.00 64.16  ? 443 ARG A CA  1 
ATOM 1675 C C   . ARG A 1 245 ? -24.257 4.250   -20.716 1.00 67.24  ? 443 ARG A C   1 
ATOM 1676 O O   . ARG A 1 245 ? -23.314 4.793   -21.301 1.00 75.58  ? 443 ARG A O   1 
ATOM 1677 C CB  . ARG A 1 245 ? -24.927 2.161   -21.930 1.00 58.48  ? 443 ARG A CB  1 
ATOM 1678 C CG  . ARG A 1 245 ? -24.918 0.644   -21.984 1.00 61.79  ? 443 ARG A CG  1 
ATOM 1679 C CD  . ARG A 1 245 ? -25.187 0.127   -23.386 1.00 58.70  ? 443 ARG A CD  1 
ATOM 1680 N NE  . ARG A 1 245 ? -25.140 -1.332  -23.443 1.00 64.52  ? 443 ARG A NE  1 
ATOM 1681 C CZ  . ARG A 1 245 ? -25.331 -2.045  -24.548 1.00 65.36  ? 443 ARG A CZ  1 
ATOM 1682 N NH1 . ARG A 1 245 ? -25.584 -1.435  -25.699 1.00 70.18  ? 443 ARG A NH1 1 
ATOM 1683 N NH2 . ARG A 1 245 ? -25.268 -3.369  -24.503 1.00 67.71  ? 443 ARG A NH2 1 
ATOM 1684 N N   . GLN A 1 246 ? -25.232 4.950   -20.134 1.00 67.53  ? 444 GLN A N   1 
ATOM 1685 C CA  . GLN A 1 246 ? -25.152 6.405   -20.074 1.00 71.17  ? 444 GLN A CA  1 
ATOM 1686 C C   . GLN A 1 246 ? -24.123 6.862   -19.047 1.00 75.11  ? 444 GLN A C   1 
ATOM 1687 O O   . GLN A 1 246 ? -23.506 7.921   -19.217 1.00 83.75  ? 444 GLN A O   1 
ATOM 1688 C CB  . GLN A 1 246 ? -26.527 6.997   -19.756 1.00 77.55  ? 444 GLN A CB  1 
ATOM 1689 C CG  . GLN A 1 246 ? -26.598 8.516   -19.834 1.00 90.05  ? 444 GLN A CG  1 
ATOM 1690 C CD  . GLN A 1 246 ? -26.497 9.044   -21.255 1.00 93.91  ? 444 GLN A CD  1 
ATOM 1691 O OE1 . GLN A 1 246 ? -26.525 8.281   -22.221 1.00 99.67  ? 444 GLN A OE1 1 
ATOM 1692 N NE2 . GLN A 1 246 ? -26.381 10.361  -21.388 1.00 80.33  ? 444 GLN A NE2 1 
ATOM 1693 N N   . ILE A 1 247 ? -23.922 6.081   -17.984 1.00 72.90  ? 445 ILE A N   1 
ATOM 1694 C CA  . ILE A 1 247 ? -22.881 6.400   -17.012 1.00 70.93  ? 445 ILE A CA  1 
ATOM 1695 C C   . ILE A 1 247 ? -21.504 6.215   -17.633 1.00 71.29  ? 445 ILE A C   1 
ATOM 1696 O O   . ILE A 1 247 ? -20.633 7.086   -17.522 1.00 76.93  ? 445 ILE A O   1 
ATOM 1697 C CB  . ILE A 1 247 ? -23.042 5.537   -15.749 1.00 71.78  ? 445 ILE A CB  1 
ATOM 1698 C CG1 . ILE A 1 247 ? -24.414 5.759   -15.117 1.00 75.20  ? 445 ILE A CG1 1 
ATOM 1699 C CG2 . ILE A 1 247 ? -21.939 5.846   -14.747 1.00 61.89  ? 445 ILE A CG2 1 
ATOM 1700 C CD1 . ILE A 1 247 ? -24.737 4.758   -14.043 1.00 76.05  ? 445 ILE A CD1 1 
ATOM 1701 N N   . VAL A 1 248 ? -21.286 5.073   -18.291 1.00 73.58  ? 446 VAL A N   1 
ATOM 1702 C CA  . VAL A 1 248 ? -20.002 4.813   -18.935 1.00 70.56  ? 446 VAL A CA  1 
ATOM 1703 C C   . VAL A 1 248 ? -19.733 5.846   -20.021 1.00 76.76  ? 446 VAL A C   1 
ATOM 1704 O O   . VAL A 1 248 ? -18.601 6.319   -20.182 1.00 78.72  ? 446 VAL A O   1 
ATOM 1705 C CB  . VAL A 1 248 ? -19.966 3.378   -19.493 1.00 62.25  ? 446 VAL A CB  1 
ATOM 1706 C CG1 . VAL A 1 248 ? -18.621 3.091   -20.144 1.00 64.48  ? 446 VAL A CG1 1 
ATOM 1707 C CG2 . VAL A 1 248 ? -20.254 2.373   -18.387 1.00 66.38  ? 446 VAL A CG2 1 
ATOM 1708 N N   . THR A 1 249 ? -20.768 6.218   -20.778 1.00 74.69  ? 447 THR A N   1 
ATOM 1709 C CA  . THR A 1 249 ? -20.612 7.277   -21.769 1.00 73.75  ? 447 THR A CA  1 
ATOM 1710 C C   . THR A 1 249 ? -20.255 8.600   -21.102 1.00 81.03  ? 447 THR A C   1 
ATOM 1711 O O   . THR A 1 249 ? -19.368 9.322   -21.572 1.00 86.63  ? 447 THR A O   1 
ATOM 1712 C CB  . THR A 1 249 ? -21.891 7.421   -22.594 1.00 82.85  ? 447 THR A CB  1 
ATOM 1713 O OG1 . THR A 1 249 ? -22.206 6.168   -23.215 1.00 84.87  ? 447 THR A OG1 1 
ATOM 1714 C CG2 . THR A 1 249 ? -21.717 8.483   -23.671 1.00 81.43  ? 447 THR A CG2 1 
ATOM 1715 N N   . GLU A 1 250 ? -20.930 8.928   -19.998 1.00 81.31  ? 448 GLU A N   1 
ATOM 1716 C CA  . GLU A 1 250 ? -20.613 10.153  -19.272 1.00 82.85  ? 448 GLU A CA  1 
ATOM 1717 C C   . GLU A 1 250 ? -19.267 10.055  -18.565 1.00 84.86  ? 448 GLU A C   1 
ATOM 1718 O O   . GLU A 1 250 ? -18.563 11.063  -18.432 1.00 83.44  ? 448 GLU A O   1 
ATOM 1719 C CB  . GLU A 1 250 ? -21.723 10.466  -18.268 1.00 78.79  ? 448 GLU A CB  1 
ATOM 1720 C CG  . GLU A 1 250 ? -21.513 11.743  -17.472 1.00 93.07  ? 448 GLU A CG  1 
ATOM 1721 C CD  . GLU A 1 250 ? -22.602 11.972  -16.443 1.00 92.63  ? 448 GLU A CD  1 
ATOM 1722 O OE1 . GLU A 1 250 ? -23.548 11.158  -16.385 1.00 95.57  ? 448 GLU A OE1 1 
ATOM 1723 O OE2 . GLU A 1 250 ? -22.513 12.966  -15.692 1.00 84.18  ? 448 GLU A OE2 1 
ATOM 1724 N N   . HIS A 1 251 ? -18.889 8.857   -18.113 1.00 84.13  ? 449 HIS A N   1 
ATOM 1725 C CA  . HIS A 1 251 ? -17.621 8.698   -17.409 1.00 82.61  ? 449 HIS A CA  1 
ATOM 1726 C C   . HIS A 1 251 ? -16.436 8.862   -18.352 1.00 82.72  ? 449 HIS A C   1 
ATOM 1727 O O   . HIS A 1 251 ? -15.428 9.479   -17.988 1.00 85.64  ? 449 HIS A O   1 
ATOM 1728 C CB  . HIS A 1 251 ? -17.573 7.336   -16.717 1.00 78.35  ? 449 HIS A CB  1 
ATOM 1729 C CG  . HIS A 1 251 ? -16.278 7.055   -16.024 1.00 81.25  ? 449 HIS A CG  1 
ATOM 1730 N ND1 . HIS A 1 251 ? -15.338 6.182   -16.528 1.00 80.89  ? 449 HIS A ND1 1 
ATOM 1731 C CD2 . HIS A 1 251 ? -15.767 7.527   -14.862 1.00 86.94  ? 449 HIS A CD2 1 
ATOM 1732 C CE1 . HIS A 1 251 ? -14.304 6.129   -15.708 1.00 86.97  ? 449 HIS A CE1 1 
ATOM 1733 N NE2 . HIS A 1 251 ? -14.538 6.937   -14.690 1.00 91.18  ? 449 HIS A NE2 1 
ATOM 1734 N N   . VAL A 1 252 ? -16.535 8.314   -19.566 1.00 83.28  ? 450 VAL A N   1 
ATOM 1735 C CA  . VAL A 1 252 ? -15.458 8.469   -20.539 1.00 80.22  ? 450 VAL A CA  1 
ATOM 1736 C C   . VAL A 1 252 ? -15.311 9.931   -20.944 1.00 80.64  ? 450 VAL A C   1 
ATOM 1737 O O   . VAL A 1 252 ? -14.193 10.431  -21.120 1.00 84.82  ? 450 VAL A O   1 
ATOM 1738 C CB  . VAL A 1 252 ? -15.703 7.558   -21.756 1.00 85.29  ? 450 VAL A CB  1 
ATOM 1739 C CG1 . VAL A 1 252 ? -14.696 7.852   -22.859 1.00 74.83  ? 450 VAL A CG1 1 
ATOM 1740 C CG2 . VAL A 1 252 ? -15.624 6.096   -21.346 1.00 72.15  ? 450 VAL A CG2 1 
ATOM 1741 N N   . GLN A 1 253 ? -16.433 10.642  -21.089 1.00 80.06  ? 451 GLN A N   1 
ATOM 1742 C CA  . GLN A 1 253 ? -16.368 12.066  -21.400 1.00 82.11  ? 451 GLN A CA  1 
ATOM 1743 C C   . GLN A 1 253 ? -15.692 12.844  -20.277 1.00 90.85  ? 451 GLN A C   1 
ATOM 1744 O O   . GLN A 1 253 ? -14.959 13.806  -20.532 1.00 98.19  ? 451 GLN A O   1 
ATOM 1745 C CB  . GLN A 1 253 ? -17.772 12.610  -21.666 1.00 83.83  ? 451 GLN A CB  1 
ATOM 1746 C CG  . GLN A 1 253 ? -18.423 12.053  -22.922 1.00 94.21  ? 451 GLN A CG  1 
ATOM 1747 C CD  . GLN A 1 253 ? -19.877 12.462  -23.058 1.00 104.69 ? 451 GLN A CD  1 
ATOM 1748 O OE1 . GLN A 1 253 ? -20.427 13.145  -22.194 1.00 100.56 ? 451 GLN A OE1 1 
ATOM 1749 N NE2 . GLN A 1 253 ? -20.509 12.044  -24.149 1.00 98.44  ? 451 GLN A NE2 1 
ATOM 1750 N N   . LEU A 1 254 ? -15.924 12.439  -19.026 1.00 89.22  ? 452 LEU A N   1 
ATOM 1751 C CA  . LEU A 1 254 ? -15.233 13.059  -17.902 1.00 90.61  ? 452 LEU A CA  1 
ATOM 1752 C C   . LEU A 1 254 ? -13.761 12.673  -17.845 1.00 92.51  ? 452 LEU A C   1 
ATOM 1753 O O   . LEU A 1 254 ? -12.959 13.419  -17.272 1.00 91.03  ? 452 LEU A O   1 
ATOM 1754 C CB  . LEU A 1 254 ? -15.919 12.683  -16.586 1.00 89.53  ? 452 LEU A CB  1 
ATOM 1755 C CG  . LEU A 1 254 ? -17.295 13.290  -16.304 1.00 97.25  ? 452 LEU A CG  1 
ATOM 1756 C CD1 . LEU A 1 254 ? -17.882 12.699  -15.031 1.00 87.18  ? 452 LEU A CD1 1 
ATOM 1757 C CD2 . LEU A 1 254 ? -17.200 14.804  -16.198 1.00 93.65  ? 452 LEU A CD2 1 
ATOM 1758 N N   . LEU A 1 255 ? -13.385 11.530  -18.427 1.00 94.70  ? 453 LEU A N   1 
ATOM 1759 C CA  . LEU A 1 255 ? -11.995 11.091  -18.390 1.00 92.95  ? 453 LEU A CA  1 
ATOM 1760 C C   . LEU A 1 255 ? -11.141 11.725  -19.477 1.00 96.00  ? 453 LEU A C   1 
ATOM 1761 O O   . LEU A 1 255 ? -9.909  11.694  -19.373 1.00 99.96  ? 453 LEU A O   1 
ATOM 1762 C CB  . LEU A 1 255 ? -11.914 9.569   -18.499 1.00 92.12  ? 453 LEU A CB  1 
ATOM 1763 C CG  . LEU A 1 255 ? -12.061 8.796   -17.184 1.00 86.92  ? 453 LEU A CG  1 
ATOM 1764 C CD1 . LEU A 1 255 ? -11.566 7.368   -17.344 1.00 90.77  ? 453 LEU A CD1 1 
ATOM 1765 C CD2 . LEU A 1 255 ? -11.320 9.503   -16.057 1.00 91.35  ? 453 LEU A CD2 1 
ATOM 1766 N N   . GLN A 1 256 ? -11.754 12.303  -20.502 1.00 96.82  ? 454 GLN A N   1 
ATOM 1767 C CA  . GLN A 1 256 ? -10.985 13.069  -21.491 1.00 105.11 ? 454 GLN A CA  1 
ATOM 1768 C C   . GLN A 1 256 ? -10.459 14.394  -20.930 1.00 110.35 ? 454 GLN A C   1 
ATOM 1769 O O   . GLN A 1 256 ? -9.973  15.231  -21.708 1.00 118.43 ? 454 GLN A O   1 
ATOM 1770 C CB  . GLN A 1 256 ? -11.840 13.331  -22.733 1.00 104.80 ? 454 GLN A CB  1 
ATOM 1771 C CG  . GLN A 1 256 ? -12.309 12.074  -23.455 1.00 99.22  ? 454 GLN A CG  1 
ATOM 1772 C CD  . GLN A 1 256 ? -11.424 11.710  -24.633 1.00 109.22 ? 454 GLN A CD  1 
ATOM 1773 O OE1 . GLN A 1 256 ? -10.440 12.390  -24.910 1.00 110.57 ? 454 GLN A OE1 1 
ATOM 1774 N NE2 . GLN A 1 256 ? -11.774 10.635  -25.335 1.00 96.95  ? 454 GLN A NE2 1 
ATOM 1775 N N   . VAL A 1 257 ? -10.546 14.579  -19.615 1.00 109.90 ? 455 VAL A N   1 
ATOM 1776 C CA  . VAL A 1 257 ? -10.092 15.792  -18.953 1.00 105.14 ? 455 VAL A CA  1 
ATOM 1777 C C   . VAL A 1 257 ? -9.051  15.438  -17.893 1.00 95.26  ? 455 VAL A C   1 
ATOM 1778 O O   . VAL A 1 257 ? -8.520  14.324  -17.871 1.00 94.76  ? 455 VAL A O   1 
ATOM 1779 C CB  . VAL A 1 257 ? -11.275 16.555  -18.320 1.00 101.57 ? 455 VAL A CB  1 
ATOM 1780 C CG1 . VAL A 1 257 ? -10.811 17.885  -17.732 1.00 97.28  ? 455 VAL A CG1 1 
ATOM 1781 C CG2 . VAL A 1 257 ? -12.380 16.771  -19.336 1.00 91.21  ? 455 VAL A CG2 1 
ATOM 1782 N N   . LEU B 2 5   ? -8.342  -2.453  -20.006 1.00 81.72  ? 141 LEU B N   1 
ATOM 1783 C CA  . LEU B 2 5   ? -7.076  -2.249  -20.701 1.00 86.39  ? 141 LEU B CA  1 
ATOM 1784 C C   . LEU B 2 5   ? -6.955  -3.200  -21.887 1.00 90.00  ? 141 LEU B C   1 
ATOM 1785 O O   . LEU B 2 5   ? -6.117  -3.000  -22.769 1.00 97.30  ? 141 LEU B O   1 
ATOM 1786 C CB  . LEU B 2 5   ? -5.899  -2.443  -19.738 1.00 82.89  ? 141 LEU B CB  1 
ATOM 1787 C CG  . LEU B 2 5   ? -4.490  -2.158  -20.268 1.00 84.73  ? 141 LEU B CG  1 
ATOM 1788 C CD1 . LEU B 2 5   ? -4.409  -0.756  -20.853 1.00 90.88  ? 141 LEU B CD1 1 
ATOM 1789 C CD2 . LEU B 2 5   ? -3.443  -2.353  -19.182 1.00 82.38  ? 141 LEU B CD2 1 
ATOM 1790 N N   . GLU B 2 6   ? -7.797  -4.240  -21.886 1.00 86.53  ? 142 GLU B N   1 
ATOM 1791 C CA  . GLU B 2 6   ? -7.806  -5.300  -22.893 1.00 87.55  ? 142 GLU B CA  1 
ATOM 1792 C C   . GLU B 2 6   ? -6.564  -6.181  -22.781 1.00 90.16  ? 142 GLU B C   1 
ATOM 1793 O O   . GLU B 2 6   ? -6.623  -7.380  -23.072 1.00 94.11  ? 142 GLU B O   1 
ATOM 1794 C CB  . GLU B 2 6   ? -7.939  -4.717  -24.306 1.00 88.04  ? 142 GLU B CB  1 
ATOM 1795 C CG  . GLU B 2 6   ? -8.077  -5.755  -25.407 1.00 84.56  ? 142 GLU B CG  1 
ATOM 1796 C CD  . GLU B 2 6   ? -8.410  -5.138  -26.752 1.00 95.05  ? 142 GLU B CD  1 
ATOM 1797 O OE1 . GLU B 2 6   ? -8.831  -3.962  -26.781 1.00 95.72  ? 142 GLU B OE1 1 
ATOM 1798 O OE2 . GLU B 2 6   ? -8.251  -5.828  -27.781 1.00 87.71  ? 142 GLU B OE2 1 
ATOM 1799 N N   . ALA B 2 7   ? -5.438  -5.602  -22.357 1.00 88.01  ? 143 ALA B N   1 
ATOM 1800 C CA  . ALA B 2 7   ? -4.255  -6.401  -22.063 1.00 85.58  ? 143 ALA B CA  1 
ATOM 1801 C C   . ALA B 2 7   ? -4.390  -7.140  -20.738 1.00 87.07  ? 143 ALA B C   1 
ATOM 1802 O O   . ALA B 2 7   ? -3.859  -8.247  -20.594 1.00 83.80  ? 143 ALA B O   1 
ATOM 1803 C CB  . ALA B 2 7   ? -3.009  -5.514  -22.047 1.00 86.24  ? 143 ALA B CB  1 
ATOM 1804 N N   . ILE B 2 8   ? -5.087  -6.548  -19.767 1.00 85.65  ? 144 ILE B N   1 
ATOM 1805 C CA  . ILE B 2 8   ? -5.358  -7.246  -18.515 1.00 79.98  ? 144 ILE B CA  1 
ATOM 1806 C C   . ILE B 2 8   ? -6.354  -8.374  -18.745 1.00 83.92  ? 144 ILE B C   1 
ATOM 1807 O O   . ILE B 2 8   ? -6.234  -9.459  -18.162 1.00 72.14  ? 144 ILE B O   1 
ATOM 1808 C CB  . ILE B 2 8   ? -5.861  -6.255  -17.450 1.00 77.05  ? 144 ILE B CB  1 
ATOM 1809 C CG1 . ILE B 2 8   ? -4.852  -5.123  -17.257 1.00 76.08  ? 144 ILE B CG1 1 
ATOM 1810 C CG2 . ILE B 2 8   ? -6.120  -6.970  -16.131 1.00 83.50  ? 144 ILE B CG2 1 
ATOM 1811 C CD1 . ILE B 2 8   ? -5.319  -4.047  -16.305 1.00 85.99  ? 144 ILE B CD1 1 
ATOM 1812 N N   . ILE B 2 9   ? -7.350  -8.140  -19.601 1.00 83.64  ? 145 ILE B N   1 
ATOM 1813 C CA  . ILE B 2 9   ? -8.326  -9.179  -19.912 1.00 78.63  ? 145 ILE B CA  1 
ATOM 1814 C C   . ILE B 2 9   ? -7.665  -10.310 -20.689 1.00 87.63  ? 145 ILE B C   1 
ATOM 1815 O O   . ILE B 2 9   ? -7.788  -11.486 -20.328 1.00 84.84  ? 145 ILE B O   1 
ATOM 1816 C CB  . ILE B 2 9   ? -9.519  -8.579  -20.678 1.00 75.92  ? 145 ILE B CB  1 
ATOM 1817 C CG1 . ILE B 2 9   ? -10.166 -7.462  -19.856 1.00 78.29  ? 145 ILE B CG1 1 
ATOM 1818 C CG2 . ILE B 2 9   ? -10.538 -9.657  -21.006 1.00 71.49  ? 145 ILE B CG2 1 
ATOM 1819 C CD1 . ILE B 2 9   ? -11.324 -6.782  -20.550 1.00 69.81  ? 145 ILE B CD1 1 
ATOM 1820 N N   . ARG B 2 10  ? -6.937  -9.974  -21.756 1.00 85.77  ? 146 ARG B N   1 
ATOM 1821 C CA  . ARG B 2 10  ? -6.197  -10.974 -22.519 1.00 83.35  ? 146 ARG B CA  1 
ATOM 1822 C C   . ARG B 2 10  ? -5.025  -11.518 -21.712 1.00 85.44  ? 146 ARG B C   1 
ATOM 1823 O O   . ARG B 2 10  ? -3.864  -11.351 -22.098 1.00 103.96 ? 146 ARG B O   1 
ATOM 1824 C CB  . ARG B 2 10  ? -5.692  -10.394 -23.842 1.00 84.87  ? 146 ARG B CB  1 
ATOM 1825 C CG  . ARG B 2 10  ? -6.584  -10.693 -25.033 1.00 95.35  ? 146 ARG B CG  1 
ATOM 1826 C CD  . ARG B 2 10  ? -5.888  -10.372 -26.345 1.00 91.62  ? 146 ARG B CD  1 
ATOM 1827 N NE  . ARG B 2 10  ? -6.788  -10.506 -27.486 1.00 86.31  ? 146 ARG B NE  1 
ATOM 1828 C CZ  . ARG B 2 10  ? -7.488  -9.501  -28.005 1.00 88.67  ? 146 ARG B CZ  1 
ATOM 1829 N NH1 . ARG B 2 10  ? -7.388  -8.286  -27.485 1.00 92.70  ? 146 ARG B NH1 1 
ATOM 1830 N NH2 . ARG B 2 10  ? -8.284  -9.710  -29.044 1.00 86.95  ? 146 ARG B NH2 1 
ATOM 1831 N N   . LYS B 2 11  ? -5.326  -12.172 -20.592 1.00 79.51  ? 147 LYS B N   1 
ATOM 1832 C CA  . LYS B 2 11  ? -4.315  -12.762 -19.728 1.00 83.20  ? 147 LYS B CA  1 
ATOM 1833 C C   . LYS B 2 11  ? -4.978  -13.751 -18.781 1.00 87.01  ? 147 LYS B C   1 
ATOM 1834 O O   . LYS B 2 11  ? -4.544  -14.902 -18.666 1.00 87.25  ? 147 LYS B O   1 
ATOM 1835 C CB  . LYS B 2 11  ? -3.569  -11.684 -18.938 1.00 79.67  ? 147 LYS B CB  1 
ATOM 1836 C CG  . LYS B 2 11  ? -2.482  -12.236 -18.029 1.00 76.39  ? 147 LYS B CG  1 
ATOM 1837 C CD  . LYS B 2 11  ? -2.081  -11.237 -16.954 1.00 85.30  ? 147 LYS B CD  1 
ATOM 1838 C CE  . LYS B 2 11  ? -1.620  -9.921  -17.555 1.00 87.89  ? 147 LYS B CE  1 
ATOM 1839 N NZ  . LYS B 2 11  ? -1.111  -8.987  -16.513 1.00 92.29  ? 147 LYS B NZ  1 
ATOM 1840 N N   . ALA B 2 12  ? -6.039  -13.307 -18.101 1.00 83.44  ? 148 ALA B N   1 
ATOM 1841 C CA  . ALA B 2 12  ? -6.766  -14.187 -17.197 1.00 78.20  ? 148 ALA B CA  1 
ATOM 1842 C C   . ALA B 2 12  ? -7.519  -15.281 -17.943 1.00 80.44  ? 148 ALA B C   1 
ATOM 1843 O O   . ALA B 2 12  ? -7.800  -16.333 -17.358 1.00 88.50  ? 148 ALA B O   1 
ATOM 1844 C CB  . ALA B 2 12  ? -7.731  -13.372 -16.336 1.00 80.52  ? 148 ALA B CB  1 
ATOM 1845 N N   . LEU B 2 13  ? -7.847  -15.063 -19.213 1.00 84.37  ? 149 LEU B N   1 
ATOM 1846 C CA  . LEU B 2 13  ? -8.471  -16.102 -20.024 1.00 88.78  ? 149 LEU B CA  1 
ATOM 1847 C C   . LEU B 2 13  ? -7.478  -17.223 -20.312 1.00 91.82  ? 149 LEU B C   1 
ATOM 1848 O O   . LEU B 2 13  ? -6.287  -16.978 -20.500 1.00 95.56  ? 149 LEU B O   1 
ATOM 1849 C CB  . LEU B 2 13  ? -9.008  -15.530 -21.341 1.00 79.46  ? 149 LEU B CB  1 
ATOM 1850 C CG  . LEU B 2 13  ? -10.357 -14.803 -21.339 1.00 73.17  ? 149 LEU B CG  1 
ATOM 1851 C CD1 . LEU B 2 13  ? -11.247 -15.301 -20.210 1.00 67.30  ? 149 LEU B CD1 1 
ATOM 1852 C CD2 . LEU B 2 13  ? -10.187 -13.295 -21.273 1.00 74.08  ? 149 LEU B CD2 1 
ATOM 1853 N N   . PRO C 1 8   ? -53.632 -7.507  -11.210 1.00 72.90  ? 206 PRO C N   1 
ATOM 1854 C CA  . PRO C 1 8   ? -54.003 -7.171  -12.588 1.00 81.43  ? 206 PRO C CA  1 
ATOM 1855 C C   . PRO C 1 8   ? -54.597 -8.359  -13.342 1.00 87.46  ? 206 PRO C C   1 
ATOM 1856 O O   . PRO C 1 8   ? -53.925 -9.374  -13.531 1.00 85.69  ? 206 PRO C O   1 
ATOM 1857 C CB  . PRO C 1 8   ? -52.674 -6.735  -13.206 1.00 82.66  ? 206 PRO C CB  1 
ATOM 1858 C CG  . PRO C 1 8   ? -51.907 -6.181  -12.054 1.00 86.45  ? 206 PRO C CG  1 
ATOM 1859 C CD  . PRO C 1 8   ? -52.277 -7.037  -10.873 1.00 70.46  ? 206 PRO C CD  1 
ATOM 1860 N N   . GLU C 1 9   ? -55.849 -8.219  -13.767 1.00 91.79  ? 207 GLU C N   1 
ATOM 1861 C CA  . GLU C 1 9   ? -56.556 -9.305  -14.429 1.00 99.33  ? 207 GLU C CA  1 
ATOM 1862 C C   . GLU C 1 9   ? -55.955 -9.588  -15.803 1.00 94.84  ? 207 GLU C C   1 
ATOM 1863 O O   . GLU C 1 9   ? -55.414 -8.700  -16.467 1.00 89.81  ? 207 GLU C O   1 
ATOM 1864 C CB  . GLU C 1 9   ? -58.039 -8.958  -14.566 1.00 105.95 ? 207 GLU C CB  1 
ATOM 1865 C CG  . GLU C 1 9   ? -58.943 -10.118 -14.955 1.00 105.51 ? 207 GLU C CG  1 
ATOM 1866 C CD  . GLU C 1 9   ? -59.529 -10.831 -13.752 1.00 115.93 ? 207 GLU C CD  1 
ATOM 1867 O OE1 . GLU C 1 9   ? -58.977 -10.682 -12.641 1.00 108.66 ? 207 GLU C OE1 1 
ATOM 1868 O OE2 . GLU C 1 9   ? -60.548 -11.533 -13.915 1.00 119.49 ? 207 GLU C OE2 1 
ATOM 1869 N N   . SER C 1 10  ? -56.056 -10.851 -16.226 1.00 84.96  ? 208 SER C N   1 
ATOM 1870 C CA  . SER C 1 10  ? -55.531 -11.243 -17.530 1.00 78.12  ? 208 SER C CA  1 
ATOM 1871 C C   . SER C 1 10  ? -56.337 -10.614 -18.660 1.00 88.90  ? 208 SER C C   1 
ATOM 1872 O O   . SER C 1 10  ? -55.769 -10.041 -19.598 1.00 79.68  ? 208 SER C O   1 
ATOM 1873 C CB  . SER C 1 10  ? -55.525 -12.767 -17.655 1.00 89.07  ? 208 SER C CB  1 
ATOM 1874 O OG  . SER C 1 10  ? -55.075 -13.172 -18.936 1.00 74.53  ? 208 SER C OG  1 
ATOM 1875 N N   . ALA C 1 11  ? -57.667 -10.713 -18.591 1.00 93.58  ? 209 ALA C N   1 
ATOM 1876 C CA  . ALA C 1 11  ? -58.511 -10.106 -19.614 1.00 79.73  ? 209 ALA C CA  1 
ATOM 1877 C C   . ALA C 1 11  ? -58.488 -8.585  -19.553 1.00 70.66  ? 209 ALA C C   1 
ATOM 1878 O O   . ALA C 1 11  ? -58.843 -7.933  -20.540 1.00 77.93  ? 209 ALA C O   1 
ATOM 1879 C CB  . ALA C 1 11  ? -59.947 -10.614 -19.483 1.00 83.46  ? 209 ALA C CB  1 
ATOM 1880 N N   . ASP C 1 12  ? -58.085 -8.009  -18.419 1.00 76.91  ? 210 ASP C N   1 
ATOM 1881 C CA  . ASP C 1 12  ? -57.915 -6.562  -18.344 1.00 82.13  ? 210 ASP C CA  1 
ATOM 1882 C C   . ASP C 1 12  ? -56.707 -6.101  -19.148 1.00 74.02  ? 210 ASP C C   1 
ATOM 1883 O O   . ASP C 1 12  ? -56.719 -4.997  -19.705 1.00 73.07  ? 210 ASP C O   1 
ATOM 1884 C CB  . ASP C 1 12  ? -57.789 -6.126  -16.884 1.00 97.78  ? 210 ASP C CB  1 
ATOM 1885 C CG  . ASP C 1 12  ? -59.130 -5.805  -16.254 1.00 110.85 ? 210 ASP C CG  1 
ATOM 1886 O OD1 . ASP C 1 12  ? -59.491 -4.610  -16.201 1.00 123.69 ? 210 ASP C OD1 1 
ATOM 1887 O OD2 . ASP C 1 12  ? -59.836 -6.745  -15.834 1.00 103.57 ? 210 ASP C OD2 1 
ATOM 1888 N N   . LEU C 1 13  ? -55.662 -6.927  -19.223 1.00 75.30  ? 211 LEU C N   1 
ATOM 1889 C CA  . LEU C 1 13  ? -54.496 -6.599  -20.032 1.00 69.02  ? 211 LEU C CA  1 
ATOM 1890 C C   . LEU C 1 13  ? -54.747 -6.792  -21.521 1.00 67.10  ? 211 LEU C C   1 
ATOM 1891 O O   . LEU C 1 13  ? -54.060 -6.168  -22.337 1.00 67.11  ? 211 LEU C O   1 
ATOM 1892 C CB  . LEU C 1 13  ? -53.296 -7.443  -19.595 1.00 62.92  ? 211 LEU C CB  1 
ATOM 1893 C CG  . LEU C 1 13  ? -52.837 -7.262  -18.147 1.00 62.03  ? 211 LEU C CG  1 
ATOM 1894 C CD1 . LEU C 1 13  ? -51.649 -8.161  -17.839 1.00 46.10  ? 211 LEU C CD1 1 
ATOM 1895 C CD2 . LEU C 1 13  ? -52.498 -5.805  -17.868 1.00 54.90  ? 211 LEU C CD2 1 
ATOM 1896 N N   . ARG C 1 14  ? -55.710 -7.637  -21.894 1.00 67.38  ? 212 ARG C N   1 
ATOM 1897 C CA  . ARG C 1 14  ? -56.041 -7.812  -23.303 1.00 66.84  ? 212 ARG C CA  1 
ATOM 1898 C C   . ARG C 1 14  ? -56.899 -6.662  -23.818 1.00 66.71  ? 212 ARG C C   1 
ATOM 1899 O O   . ARG C 1 14  ? -56.722 -6.214  -24.957 1.00 61.19  ? 212 ARG C O   1 
ATOM 1900 C CB  . ARG C 1 14  ? -56.757 -9.146  -23.515 1.00 68.60  ? 212 ARG C CB  1 
ATOM 1901 C CG  . ARG C 1 14  ? -55.999 -10.358 -22.991 1.00 68.57  ? 212 ARG C CG  1 
ATOM 1902 C CD  . ARG C 1 14  ? -54.684 -10.577 -23.728 1.00 64.50  ? 212 ARG C CD  1 
ATOM 1903 N NE  . ARG C 1 14  ? -54.872 -10.780 -25.161 1.00 63.47  ? 212 ARG C NE  1 
ATOM 1904 C CZ  . ARG C 1 14  ? -54.462 -9.930  -26.096 1.00 75.34  ? 212 ARG C CZ  1 
ATOM 1905 N NH1 . ARG C 1 14  ? -54.676 -10.195 -27.378 1.00 74.37  ? 212 ARG C NH1 1 
ATOM 1906 N NH2 . ARG C 1 14  ? -53.828 -8.818  -25.751 1.00 65.13  ? 212 ARG C NH2 1 
ATOM 1907 N N   . ALA C 1 15  ? -57.834 -6.178  -22.996 1.00 57.35  ? 213 ALA C N   1 
ATOM 1908 C CA  . ALA C 1 15  ? -58.654 -5.039  -23.396 1.00 58.77  ? 213 ALA C CA  1 
ATOM 1909 C C   . ALA C 1 15  ? -57.813 -3.783  -23.575 1.00 62.26  ? 213 ALA C C   1 
ATOM 1910 O O   . ALA C 1 15  ? -58.108 -2.960  -24.449 1.00 69.31  ? 213 ALA C O   1 
ATOM 1911 C CB  . ALA C 1 15  ? -59.762 -4.798  -22.369 1.00 54.09  ? 213 ALA C CB  1 
ATOM 1912 N N   . LEU C 1 16  ? -56.769 -3.615  -22.759 1.00 58.21  ? 214 LEU C N   1 
ATOM 1913 C CA  . LEU C 1 16  ? -55.863 -2.487  -22.945 1.00 64.47  ? 214 LEU C CA  1 
ATOM 1914 C C   . LEU C 1 16  ? -55.078 -2.623  -24.243 1.00 59.91  ? 214 LEU C C   1 
ATOM 1915 O O   . LEU C 1 16  ? -54.843 -1.629  -24.942 1.00 57.61  ? 214 LEU C O   1 
ATOM 1916 C CB  . LEU C 1 16  ? -54.916 -2.376  -21.749 1.00 46.29  ? 214 LEU C CB  1 
ATOM 1917 C CG  . LEU C 1 16  ? -53.819 -1.311  -21.839 1.00 52.91  ? 214 LEU C CG  1 
ATOM 1918 C CD1 . LEU C 1 16  ? -54.420 0.077   -21.982 1.00 50.22  ? 214 LEU C CD1 1 
ATOM 1919 C CD2 . LEU C 1 16  ? -52.902 -1.380  -20.627 1.00 60.34  ? 214 LEU C CD2 1 
ATOM 1920 N N   . ALA C 1 17  ? -54.669 -3.847  -24.583 1.00 49.92  ? 215 ALA C N   1 
ATOM 1921 C CA  . ALA C 1 17  ? -53.934 -4.067  -25.824 1.00 60.81  ? 215 ALA C CA  1 
ATOM 1922 C C   . ALA C 1 17  ? -54.794 -3.742  -27.038 1.00 56.61  ? 215 ALA C C   1 
ATOM 1923 O O   . ALA C 1 17  ? -54.314 -3.137  -28.003 1.00 64.62  ? 215 ALA C O   1 
ATOM 1924 C CB  . ALA C 1 17  ? -53.435 -5.509  -25.889 1.00 41.22  ? 215 ALA C CB  1 
ATOM 1925 N N   . LYS C 1 18  ? -56.069 -4.138  -27.009 1.00 62.33  ? 216 LYS C N   1 
ATOM 1926 C CA  . LYS C 1 18  ? -56.963 -3.823  -28.118 1.00 59.39  ? 216 LYS C CA  1 
ATOM 1927 C C   . LYS C 1 18  ? -57.270 -2.333  -28.186 1.00 65.56  ? 216 LYS C C   1 
ATOM 1928 O O   . LYS C 1 18  ? -57.432 -1.785  -29.282 1.00 71.52  ? 216 LYS C O   1 
ATOM 1929 C CB  . LYS C 1 18  ? -58.258 -4.626  -27.993 1.00 68.36  ? 216 LYS C CB  1 
ATOM 1930 C CG  . LYS C 1 18  ? -58.060 -6.133  -27.997 1.00 69.10  ? 216 LYS C CG  1 
ATOM 1931 C CD  . LYS C 1 18  ? -57.501 -6.617  -29.325 1.00 86.73  ? 216 LYS C CD  1 
ATOM 1932 C CE  . LYS C 1 18  ? -57.291 -8.123  -29.317 1.00 82.36  ? 216 LYS C CE  1 
ATOM 1933 N NZ  . LYS C 1 18  ? -58.550 -8.858  -29.014 1.00 88.26  ? 216 LYS C NZ  1 
ATOM 1934 N N   . HIS C 1 19  ? -57.353 -1.664  -27.034 1.00 56.61  ? 217 HIS C N   1 
ATOM 1935 C CA  . HIS C 1 19  ? -57.610 -0.227  -27.027 1.00 58.40  ? 217 HIS C CA  1 
ATOM 1936 C C   . HIS C 1 19  ? -56.434 0.542   -27.615 1.00 64.84  ? 217 HIS C C   1 
ATOM 1937 O O   . HIS C 1 19  ? -56.619 1.439   -28.446 1.00 61.81  ? 217 HIS C O   1 
ATOM 1938 C CB  . HIS C 1 19  ? -57.906 0.246   -25.604 1.00 55.83  ? 217 HIS C CB  1 
ATOM 1939 C CG  . HIS C 1 19  ? -57.935 1.735   -25.457 1.00 64.88  ? 217 HIS C CG  1 
ATOM 1940 N ND1 . HIS C 1 19  ? -58.800 2.538   -26.168 1.00 65.74  ? 217 HIS C ND1 1 
ATOM 1941 C CD2 . HIS C 1 19  ? -57.200 2.569   -24.682 1.00 62.96  ? 217 HIS C CD2 1 
ATOM 1942 C CE1 . HIS C 1 19  ? -58.600 3.801   -25.837 1.00 66.50  ? 217 HIS C CE1 1 
ATOM 1943 N NE2 . HIS C 1 19  ? -57.634 3.847   -24.937 1.00 55.65  ? 217 HIS C NE2 1 
ATOM 1944 N N   . LEU C 1 20  ? -55.212 0.206   -27.191 1.00 65.83  ? 218 LEU C N   1 
ATOM 1945 C CA  . LEU C 1 20  ? -54.033 0.876   -27.727 1.00 54.35  ? 218 LEU C CA  1 
ATOM 1946 C C   . LEU C 1 20  ? -53.847 0.586   -29.210 1.00 56.77  ? 218 LEU C C   1 
ATOM 1947 O O   . LEU C 1 20  ? -53.346 1.442   -29.948 1.00 60.30  ? 218 LEU C O   1 
ATOM 1948 C CB  . LEU C 1 20  ? -52.788 0.456   -26.945 1.00 46.14  ? 218 LEU C CB  1 
ATOM 1949 C CG  . LEU C 1 20  ? -52.753 0.845   -25.466 1.00 50.98  ? 218 LEU C CG  1 
ATOM 1950 C CD1 . LEU C 1 20  ? -51.538 0.241   -24.783 1.00 47.61  ? 218 LEU C CD1 1 
ATOM 1951 C CD2 . LEU C 1 20  ? -52.761 2.358   -25.310 1.00 48.54  ? 218 LEU C CD2 1 
ATOM 1952 N N   . TYR C 1 21  ? -54.242 -0.606  -29.665 1.00 51.59  ? 219 TYR C N   1 
ATOM 1953 C CA  . TYR C 1 21  ? -54.125 -0.926  -31.083 1.00 56.53  ? 219 TYR C CA  1 
ATOM 1954 C C   . TYR C 1 21  ? -55.124 -0.130  -31.913 1.00 59.12  ? 219 TYR C C   1 
ATOM 1955 O O   . TYR C 1 21  ? -54.793 0.339   -33.009 1.00 61.91  ? 219 TYR C O   1 
ATOM 1956 C CB  . TYR C 1 21  ? -54.318 -2.426  -31.304 1.00 58.47  ? 219 TYR C CB  1 
ATOM 1957 C CG  . TYR C 1 21  ? -54.381 -2.817  -32.763 1.00 55.84  ? 219 TYR C CG  1 
ATOM 1958 C CD1 . TYR C 1 21  ? -53.229 -2.886  -33.534 1.00 63.48  ? 219 TYR C CD1 1 
ATOM 1959 C CD2 . TYR C 1 21  ? -55.594 -3.119  -33.369 1.00 64.60  ? 219 TYR C CD2 1 
ATOM 1960 C CE1 . TYR C 1 21  ? -53.282 -3.242  -34.869 1.00 50.93  ? 219 TYR C CE1 1 
ATOM 1961 C CE2 . TYR C 1 21  ? -55.657 -3.476  -34.703 1.00 73.87  ? 219 TYR C CE2 1 
ATOM 1962 C CZ  . TYR C 1 21  ? -54.499 -3.536  -35.448 1.00 69.61  ? 219 TYR C CZ  1 
ATOM 1963 O OH  . TYR C 1 21  ? -54.556 -3.892  -36.776 1.00 76.54  ? 219 TYR C OH  1 
ATOM 1964 N N   . ASP C 1 22  ? -56.351 0.029   -31.412 1.00 65.25  ? 220 ASP C N   1 
ATOM 1965 C CA  . ASP C 1 22  ? -57.342 0.828   -32.126 1.00 61.86  ? 220 ASP C CA  1 
ATOM 1966 C C   . ASP C 1 22  ? -56.908 2.284   -32.220 1.00 55.62  ? 220 ASP C C   1 
ATOM 1967 O O   . ASP C 1 22  ? -57.115 2.938   -33.249 1.00 67.65  ? 220 ASP C O   1 
ATOM 1968 C CB  . ASP C 1 22  ? -58.704 0.714   -31.441 1.00 65.61  ? 220 ASP C CB  1 
ATOM 1969 C CG  . ASP C 1 22  ? -59.285 -0.684  -31.526 1.00 64.25  ? 220 ASP C CG  1 
ATOM 1970 O OD1 . ASP C 1 22  ? -59.059 -1.361  -32.550 1.00 69.77  ? 220 ASP C OD1 1 
ATOM 1971 O OD2 . ASP C 1 22  ? -59.968 -1.105  -30.569 1.00 72.74  ? 220 ASP C OD2 1 
ATOM 1972 N N   . SER C 1 23  ? -56.300 2.811   -31.154 1.00 55.26  ? 221 SER C N   1 
ATOM 1973 C CA  . SER C 1 23  ? -55.775 4.170   -31.201 1.00 47.88  ? 221 SER C CA  1 
ATOM 1974 C C   . SER C 1 23  ? -54.525 4.253   -32.067 1.00 51.51  ? 221 SER C C   1 
ATOM 1975 O O   . SER C 1 23  ? -54.258 5.298   -32.672 1.00 63.34  ? 221 SER C O   1 
ATOM 1976 C CB  . SER C 1 23  ? -55.479 4.661   -29.786 1.00 58.19  ? 221 SER C CB  1 
ATOM 1977 O OG  . SER C 1 23  ? -56.618 4.533   -28.952 1.00 73.87  ? 221 SER C OG  1 
ATOM 1978 N N   . TYR C 1 24  ? -53.750 3.167   -32.131 1.00 51.54  ? 222 TYR C N   1 
ATOM 1979 C CA  . TYR C 1 24  ? -52.587 3.121   -33.009 1.00 49.95  ? 222 TYR C CA  1 
ATOM 1980 C C   . TYR C 1 24  ? -52.988 3.239   -34.474 1.00 51.43  ? 222 TYR C C   1 
ATOM 1981 O O   . TYR C 1 24  ? -52.260 3.840   -35.271 1.00 60.13  ? 222 TYR C O   1 
ATOM 1982 C CB  . TYR C 1 24  ? -51.814 1.824   -32.760 1.00 41.86  ? 222 TYR C CB  1 
ATOM 1983 C CG  . TYR C 1 24  ? -50.585 1.619   -33.619 1.00 44.72  ? 222 TYR C CG  1 
ATOM 1984 C CD1 . TYR C 1 24  ? -49.345 2.092   -33.214 1.00 45.89  ? 222 TYR C CD1 1 
ATOM 1985 C CD2 . TYR C 1 24  ? -50.662 0.924   -34.819 1.00 53.76  ? 222 TYR C CD2 1 
ATOM 1986 C CE1 . TYR C 1 24  ? -48.217 1.895   -33.991 1.00 54.22  ? 222 TYR C CE1 1 
ATOM 1987 C CE2 . TYR C 1 24  ? -49.542 0.724   -35.602 1.00 47.45  ? 222 TYR C CE2 1 
ATOM 1988 C CZ  . TYR C 1 24  ? -48.322 1.210   -35.183 1.00 43.53  ? 222 TYR C CZ  1 
ATOM 1989 O OH  . TYR C 1 24  ? -47.206 1.010   -35.962 1.00 49.21  ? 222 TYR C OH  1 
ATOM 1990 N N   . ILE C 1 25  ? -54.142 2.679   -34.843 1.00 56.77  ? 223 ILE C N   1 
ATOM 1991 C CA  . ILE C 1 25  ? -54.592 2.746   -36.230 1.00 56.70  ? 223 ILE C CA  1 
ATOM 1992 C C   . ILE C 1 25  ? -55.130 4.135   -36.552 1.00 62.38  ? 223 ILE C C   1 
ATOM 1993 O O   . ILE C 1 25  ? -54.884 4.674   -37.637 1.00 61.90  ? 223 ILE C O   1 
ATOM 1994 C CB  . ILE C 1 25  ? -55.641 1.652   -36.501 1.00 56.14  ? 223 ILE C CB  1 
ATOM 1995 C CG1 . ILE C 1 25  ? -55.040 0.264   -36.275 1.00 51.37  ? 223 ILE C CG1 1 
ATOM 1996 C CG2 . ILE C 1 25  ? -56.189 1.774   -37.916 1.00 62.06  ? 223 ILE C CG2 1 
ATOM 1997 C CD1 . ILE C 1 25  ? -53.906 -0.072  -37.218 1.00 55.68  ? 223 ILE C CD1 1 
ATOM 1998 N N   . LYS C 1 26  ? -55.857 4.741   -35.611 1.00 61.84  ? 224 LYS C N   1 
ATOM 1999 C CA  . LYS C 1 26  ? -56.468 6.044   -35.850 1.00 59.95  ? 224 LYS C CA  1 
ATOM 2000 C C   . LYS C 1 26  ? -55.460 7.185   -35.830 1.00 59.98  ? 224 LYS C C   1 
ATOM 2001 O O   . LYS C 1 26  ? -55.758 8.263   -36.354 1.00 71.30  ? 224 LYS C O   1 
ATOM 2002 C CB  . LYS C 1 26  ? -57.558 6.309   -34.810 1.00 63.79  ? 224 LYS C CB  1 
ATOM 2003 C CG  . LYS C 1 26  ? -58.682 5.289   -34.805 1.00 66.72  ? 224 LYS C CG  1 
ATOM 2004 C CD  . LYS C 1 26  ? -59.660 5.557   -33.672 1.00 73.35  ? 224 LYS C CD  1 
ATOM 2005 C CE  . LYS C 1 26  ? -60.757 4.507   -33.623 1.00 84.57  ? 224 LYS C CE  1 
ATOM 2006 N NZ  . LYS C 1 26  ? -61.696 4.738   -32.491 1.00 90.44  ? 224 LYS C NZ  1 
ATOM 2007 N N   . SER C 1 27  ? -54.283 6.980   -35.241 1.00 52.70  ? 225 SER C N   1 
ATOM 2008 C CA  . SER C 1 27  ? -53.305 8.050   -35.089 1.00 51.87  ? 225 SER C CA  1 
ATOM 2009 C C   . SER C 1 27  ? -52.210 8.031   -36.145 1.00 55.24  ? 225 SER C C   1 
ATOM 2010 O O   . SER C 1 27  ? -51.667 9.091   -36.474 1.00 53.99  ? 225 SER C O   1 
ATOM 2011 C CB  . SER C 1 27  ? -52.657 7.983   -33.701 1.00 51.41  ? 225 SER C CB  1 
ATOM 2012 O OG  . SER C 1 27  ? -53.632 8.089   -32.679 1.00 52.36  ? 225 SER C OG  1 
ATOM 2013 N N   . PHE C 1 28  ? -51.869 6.863   -36.682 1.00 54.00  ? 226 PHE C N   1 
ATOM 2014 C CA  . PHE C 1 28  ? -50.785 6.739   -37.649 1.00 56.58  ? 226 PHE C CA  1 
ATOM 2015 C C   . PHE C 1 28  ? -51.344 6.277   -38.988 1.00 58.58  ? 226 PHE C C   1 
ATOM 2016 O O   . PHE C 1 28  ? -51.982 5.211   -39.052 1.00 64.39  ? 226 PHE C O   1 
ATOM 2017 C CB  . PHE C 1 28  ? -49.718 5.766   -37.144 1.00 52.99  ? 226 PHE C CB  1 
ATOM 2018 C CG  . PHE C 1 28  ? -49.181 6.113   -35.784 1.00 57.93  ? 226 PHE C CG  1 
ATOM 2019 C CD1 . PHE C 1 28  ? -48.247 7.126   -35.631 1.00 59.89  ? 226 PHE C CD1 1 
ATOM 2020 C CD2 . PHE C 1 28  ? -49.611 5.430   -34.659 1.00 50.76  ? 226 PHE C CD2 1 
ATOM 2021 C CE1 . PHE C 1 28  ? -47.753 7.449   -34.381 1.00 53.51  ? 226 PHE C CE1 1 
ATOM 2022 C CE2 . PHE C 1 28  ? -49.120 5.747   -33.407 1.00 54.51  ? 226 PHE C CE2 1 
ATOM 2023 C CZ  . PHE C 1 28  ? -48.190 6.758   -33.267 1.00 48.13  ? 226 PHE C CZ  1 
ATOM 2024 N N   . PRO C 1 29  ? -51.140 7.029   -40.072 1.00 58.01  ? 227 PRO C N   1 
ATOM 2025 C CA  . PRO C 1 29  ? -51.713 6.635   -41.366 1.00 58.92  ? 227 PRO C CA  1 
ATOM 2026 C C   . PRO C 1 29  ? -51.049 5.398   -41.948 1.00 59.73  ? 227 PRO C C   1 
ATOM 2027 O O   . PRO C 1 29  ? -51.730 4.451   -42.355 1.00 67.44  ? 227 PRO C O   1 
ATOM 2028 C CB  . PRO C 1 29  ? -51.467 7.867   -42.251 1.00 60.86  ? 227 PRO C CB  1 
ATOM 2029 C CG  . PRO C 1 29  ? -51.128 8.983   -41.302 1.00 66.26  ? 227 PRO C CG  1 
ATOM 2030 C CD  . PRO C 1 29  ? -50.455 8.328   -40.144 1.00 62.30  ? 227 PRO C CD  1 
ATOM 2031 N N   . LEU C 1 30  ? -49.720 5.399   -41.994 1.00 51.90  ? 228 LEU C N   1 
ATOM 2032 C CA  . LEU C 1 30  ? -48.950 4.305   -42.582 1.00 55.86  ? 228 LEU C CA  1 
ATOM 2033 C C   . LEU C 1 30  ? -48.482 3.388   -41.457 1.00 57.23  ? 228 LEU C C   1 
ATOM 2034 O O   . LEU C 1 30  ? -47.509 3.687   -40.759 1.00 49.83  ? 228 LEU C O   1 
ATOM 2035 C CB  . LEU C 1 30  ? -47.778 4.846   -43.393 1.00 44.33  ? 228 LEU C CB  1 
ATOM 2036 C CG  . LEU C 1 30  ? -46.972 3.815   -44.185 1.00 60.67  ? 228 LEU C CG  1 
ATOM 2037 C CD1 . LEU C 1 30  ? -47.891 2.976   -45.058 1.00 59.43  ? 228 LEU C CD1 1 
ATOM 2038 C CD2 . LEU C 1 30  ? -45.915 4.506   -45.031 1.00 56.67  ? 228 LEU C CD2 1 
ATOM 2039 N N   . THR C 1 31  ? -49.180 2.272   -41.282 1.00 52.58  ? 229 THR C N   1 
ATOM 2040 C CA  . THR C 1 31  ? -48.813 1.275   -40.291 1.00 54.77  ? 229 THR C CA  1 
ATOM 2041 C C   . THR C 1 31  ? -47.809 0.288   -40.880 1.00 48.74  ? 229 THR C C   1 
ATOM 2042 O O   . THR C 1 31  ? -47.483 0.326   -42.068 1.00 58.09  ? 229 THR C O   1 
ATOM 2043 C CB  . THR C 1 31  ? -50.054 0.537   -39.786 1.00 59.01  ? 229 THR C CB  1 
ATOM 2044 O OG1 . THR C 1 31  ? -50.710 -0.106  -40.886 1.00 59.52  ? 229 THR C OG1 1 
ATOM 2045 C CG2 . THR C 1 31  ? -51.020 1.510   -39.126 1.00 55.44  ? 229 THR C CG2 1 
ATOM 2046 N N   . LYS C 1 32  ? -47.313 -0.611  -40.026 1.00 50.71  ? 230 LYS C N   1 
ATOM 2047 C CA  . LYS C 1 32  ? -46.360 -1.611  -40.498 1.00 50.08  ? 230 LYS C CA  1 
ATOM 2048 C C   . LYS C 1 32  ? -47.021 -2.623  -41.425 1.00 45.22  ? 230 LYS C C   1 
ATOM 2049 O O   . LYS C 1 32  ? -46.384 -3.102  -42.370 1.00 48.62  ? 230 LYS C O   1 
ATOM 2050 C CB  . LYS C 1 32  ? -45.705 -2.328  -39.315 1.00 48.47  ? 230 LYS C CB  1 
ATOM 2051 C CG  . LYS C 1 32  ? -44.647 -3.339  -39.735 1.00 46.25  ? 230 LYS C CG  1 
ATOM 2052 C CD  . LYS C 1 32  ? -43.959 -3.981  -38.545 1.00 44.50  ? 230 LYS C CD  1 
ATOM 2053 C CE  . LYS C 1 32  ? -42.882 -4.952  -39.006 1.00 40.97  ? 230 LYS C CE  1 
ATOM 2054 N NZ  . LYS C 1 32  ? -42.153 -5.569  -37.864 1.00 47.26  ? 230 LYS C NZ  1 
ATOM 2055 N N   . ALA C 1 33  ? -48.290 -2.956  -41.176 1.00 44.86  ? 231 ALA C N   1 
ATOM 2056 C CA  . ALA C 1 33  ? -48.990 -3.903  -42.039 1.00 46.34  ? 231 ALA C CA  1 
ATOM 2057 C C   . ALA C 1 33  ? -49.100 -3.368  -43.461 1.00 51.13  ? 231 ALA C C   1 
ATOM 2058 O O   . ALA C 1 33  ? -48.843 -4.089  -44.432 1.00 57.62  ? 231 ALA C O   1 
ATOM 2059 C CB  . ALA C 1 33  ? -50.375 -4.208  -41.467 1.00 46.07  ? 231 ALA C CB  1 
ATOM 2060 N N   . LYS C 1 34  ? -49.478 -2.096  -43.603 1.00 52.38  ? 232 LYS C N   1 
ATOM 2061 C CA  . LYS C 1 34  ? -49.571 -1.498  -44.930 1.00 61.84  ? 232 LYS C CA  1 
ATOM 2062 C C   . LYS C 1 34  ? -48.194 -1.279  -45.543 1.00 57.21  ? 232 LYS C C   1 
ATOM 2063 O O   . LYS C 1 34  ? -48.052 -1.307  -46.770 1.00 56.91  ? 232 LYS C O   1 
ATOM 2064 C CB  . LYS C 1 34  ? -50.343 -0.180  -44.855 1.00 58.66  ? 232 LYS C CB  1 
ATOM 2065 C CG  . LYS C 1 34  ? -51.715 -0.317  -44.212 1.00 67.85  ? 232 LYS C CG  1 
ATOM 2066 C CD  . LYS C 1 34  ? -52.352 1.037   -43.937 1.00 74.51  ? 232 LYS C CD  1 
ATOM 2067 C CE  . LYS C 1 34  ? -52.692 1.770   -45.223 1.00 84.09  ? 232 LYS C CE  1 
ATOM 2068 N NZ  . LYS C 1 34  ? -53.407 3.048   -44.951 1.00 86.72  ? 232 LYS C NZ  1 
ATOM 2069 N N   . ALA C 1 35  ? -47.171 -1.071  -44.711 1.00 56.73  ? 233 ALA C N   1 
ATOM 2070 C CA  . ALA C 1 35  ? -45.825 -0.863  -45.234 1.00 51.26  ? 233 ALA C CA  1 
ATOM 2071 C C   . ALA C 1 35  ? -45.204 -2.172  -45.706 1.00 55.42  ? 233 ALA C C   1 
ATOM 2072 O O   . ALA C 1 35  ? -44.538 -2.208  -46.747 1.00 48.23  ? 233 ALA C O   1 
ATOM 2073 C CB  . ALA C 1 35  ? -44.947 -0.204  -44.172 1.00 44.47  ? 233 ALA C CB  1 
ATOM 2074 N N   . ARG C 1 36  ? -45.406 -3.255  -44.951 1.00 56.62  ? 234 ARG C N   1 
ATOM 2075 C CA  . ARG C 1 36  ? -44.848 -4.546  -45.343 1.00 57.02  ? 234 ARG C CA  1 
ATOM 2076 C C   . ARG C 1 36  ? -45.460 -5.038  -46.649 1.00 53.59  ? 234 ARG C C   1 
ATOM 2077 O O   . ARG C 1 36  ? -44.764 -5.626  -47.485 1.00 55.15  ? 234 ARG C O   1 
ATOM 2078 C CB  . ARG C 1 36  ? -45.061 -5.571  -44.229 1.00 60.96  ? 234 ARG C CB  1 
ATOM 2079 C CG  . ARG C 1 36  ? -44.206 -5.335  -42.994 1.00 57.52  ? 234 ARG C CG  1 
ATOM 2080 C CD  . ARG C 1 36  ? -43.072 -6.344  -42.898 1.00 72.10  ? 234 ARG C CD  1 
ATOM 2081 N NE  . ARG C 1 36  ? -42.233 -6.349  -44.093 1.00 64.28  ? 234 ARG C NE  1 
ATOM 2082 C CZ  . ARG C 1 36  ? -41.177 -5.561  -44.267 1.00 70.61  ? 234 ARG C CZ  1 
ATOM 2083 N NH1 . ARG C 1 36  ? -40.827 -4.699  -43.323 1.00 70.09  ? 234 ARG C NH1 1 
ATOM 2084 N NH2 . ARG C 1 36  ? -40.471 -5.636  -45.387 1.00 55.20  ? 234 ARG C NH2 1 
ATOM 2085 N N   . ALA C 1 37  ? -46.760 -4.806  -46.843 1.00 51.47  ? 235 ALA C N   1 
ATOM 2086 C CA  . ALA C 1 37  ? -47.400 -5.204  -48.092 1.00 61.00  ? 235 ALA C CA  1 
ATOM 2087 C C   . ALA C 1 37  ? -46.849 -4.416  -49.272 1.00 63.41  ? 235 ALA C C   1 
ATOM 2088 O O   . ALA C 1 37  ? -46.753 -4.947  -50.385 1.00 71.90  ? 235 ALA C O   1 
ATOM 2089 C CB  . ALA C 1 37  ? -48.914 -5.022  -47.987 1.00 63.12  ? 235 ALA C CB  1 
ATOM 2090 N N   . ILE C 1 38  ? -46.480 -3.154  -49.049 1.00 66.89  ? 236 ILE C N   1 
ATOM 2091 C CA  . ILE C 1 38  ? -45.883 -2.352  -50.111 1.00 58.59  ? 236 ILE C CA  1 
ATOM 2092 C C   . ILE C 1 38  ? -44.491 -2.868  -50.452 1.00 62.20  ? 236 ILE C C   1 
ATOM 2093 O O   . ILE C 1 38  ? -44.127 -2.984  -51.629 1.00 68.72  ? 236 ILE C O   1 
ATOM 2094 C CB  . ILE C 1 38  ? -45.860 -0.868  -49.699 1.00 57.02  ? 236 ILE C CB  1 
ATOM 2095 C CG1 . ILE C 1 38  ? -47.277 -0.291  -49.698 1.00 64.74  ? 236 ILE C CG1 1 
ATOM 2096 C CG2 . ILE C 1 38  ? -44.960 -0.067  -50.617 1.00 47.78  ? 236 ILE C CG2 1 
ATOM 2097 C CD1 . ILE C 1 38  ? -47.342 1.167   -49.305 1.00 52.40  ? 236 ILE C CD1 1 
ATOM 2098 N N   . LEU C 1 39  ? -43.692 -3.195  -49.433 1.00 55.65  ? 237 LEU C N   1 
ATOM 2099 C CA  . LEU C 1 39  ? -42.339 -3.686  -49.668 1.00 59.70  ? 237 LEU C CA  1 
ATOM 2100 C C   . LEU C 1 39  ? -42.320 -5.091  -50.255 1.00 64.93  ? 237 LEU C C   1 
ATOM 2101 O O   . LEU C 1 39  ? -41.330 -5.469  -50.891 1.00 76.68  ? 237 LEU C O   1 
ATOM 2102 C CB  . LEU C 1 39  ? -41.538 -3.658  -48.366 1.00 46.94  ? 237 LEU C CB  1 
ATOM 2103 C CG  . LEU C 1 39  ? -41.139 -2.273  -47.861 1.00 60.03  ? 237 LEU C CG  1 
ATOM 2104 C CD1 . LEU C 1 39  ? -40.450 -2.366  -46.509 1.00 52.47  ? 237 LEU C CD1 1 
ATOM 2105 C CD2 . LEU C 1 39  ? -40.239 -1.593  -48.876 1.00 52.65  ? 237 LEU C CD2 1 
ATOM 2106 N N   . THR C 1 40  ? -43.381 -5.871  -50.057 1.00 55.69  ? 238 THR C N   1 
ATOM 2107 C CA  . THR C 1 40  ? -43.460 -7.231  -50.570 1.00 63.58  ? 238 THR C CA  1 
ATOM 2108 C C   . THR C 1 40  ? -44.268 -7.328  -51.858 1.00 82.33  ? 238 THR C C   1 
ATOM 2109 O O   . THR C 1 40  ? -44.541 -8.439  -52.323 1.00 81.24  ? 238 THR C O   1 
ATOM 2110 C CB  . THR C 1 40  ? -44.055 -8.161  -49.510 1.00 61.52  ? 238 THR C CB  1 
ATOM 2111 O OG1 . THR C 1 40  ? -45.273 -7.596  -49.009 1.00 63.87  ? 238 THR C OG1 1 
ATOM 2112 C CG2 . THR C 1 40  ? -43.079 -8.353  -48.360 1.00 50.90  ? 238 THR C CG2 1 
ATOM 2113 N N   . GLY C 1 41  ? -44.653 -6.195  -52.442 1.00 72.24  ? 239 GLY C N   1 
ATOM 2114 C CA  . GLY C 1 41  ? -45.427 -6.214  -53.672 1.00 77.59  ? 239 GLY C CA  1 
ATOM 2115 C C   . GLY C 1 41  ? -46.794 -6.843  -53.528 1.00 77.15  ? 239 GLY C C   1 
ATOM 2116 O O   . GLY C 1 41  ? -47.336 -7.366  -54.507 1.00 85.76  ? 239 GLY C O   1 
ATOM 2117 N N   . LYS C 1 42  ? -47.368 -6.806  -52.326 1.00 73.89  ? 240 LYS C N   1 
ATOM 2118 C CA  . LYS C 1 42  ? -48.663 -7.414  -52.050 1.00 79.83  ? 240 LYS C CA  1 
ATOM 2119 C C   . LYS C 1 42  ? -49.794 -6.392  -52.030 1.00 73.88  ? 240 LYS C C   1 
ATOM 2120 O O   . LYS C 1 42  ? -50.852 -6.659  -51.449 1.00 80.23  ? 240 LYS C O   1 
ATOM 2121 C CB  . LYS C 1 42  ? -48.611 -8.174  -50.724 1.00 81.15  ? 240 LYS C CB  1 
ATOM 2122 C CG  . LYS C 1 42  ? -47.583 -9.292  -50.695 1.00 83.38  ? 240 LYS C CG  1 
ATOM 2123 C CD  . LYS C 1 42  ? -47.459 -9.896  -49.307 1.00 82.89  ? 240 LYS C CD  1 
ATOM 2124 C CE  . LYS C 1 42  ? -48.802 -10.375 -48.788 1.00 79.28  ? 240 LYS C CE  1 
ATOM 2125 N NZ  . LYS C 1 42  ? -48.685 -10.955 -47.422 1.00 89.50  ? 240 LYS C NZ  1 
ATOM 2126 N N   . THR C 1 43  ? -49.597 -5.237  -52.656 1.00 84.60  ? 241 THR C N   1 
ATOM 2127 C CA  . THR C 1 43  ? -50.588 -4.174  -52.682 1.00 80.71  ? 241 THR C CA  1 
ATOM 2128 C C   . THR C 1 43  ? -51.239 -4.092  -54.056 1.00 89.17  ? 241 THR C C   1 
ATOM 2129 O O   . THR C 1 43  ? -50.660 -4.491  -55.070 1.00 92.63  ? 241 THR C O   1 
ATOM 2130 C CB  . THR C 1 43  ? -49.955 -2.823  -52.330 1.00 80.06  ? 241 THR C CB  1 
ATOM 2131 O OG1 . THR C 1 43  ? -48.791 -3.039  -51.524 1.00 91.34  ? 241 THR C OG1 1 
ATOM 2132 C CG2 . THR C 1 43  ? -50.942 -1.961  -51.556 1.00 82.56  ? 241 THR C CG2 1 
ATOM 2133 N N   . THR C 1 44  ? -52.464 -3.567  -54.076 1.00 85.28  ? 242 THR C N   1 
ATOM 2134 C CA  . THR C 1 44  ? -53.178 -3.349  -55.327 1.00 86.85  ? 242 THR C CA  1 
ATOM 2135 C C   . THR C 1 44  ? -52.741 -2.078  -56.043 1.00 89.25  ? 242 THR C C   1 
ATOM 2136 O O   . THR C 1 44  ? -53.102 -1.890  -57.210 1.00 71.82  ? 242 THR C O   1 
ATOM 2137 C CB  . THR C 1 44  ? -54.687 -3.297  -55.071 1.00 89.92  ? 242 THR C CB  1 
ATOM 2138 O OG1 . THR C 1 44  ? -55.360 -2.852  -56.255 1.00 86.46  ? 242 THR C OG1 1 
ATOM 2139 C CG2 . THR C 1 44  ? -55.001 -2.348  -53.924 1.00 97.40  ? 242 THR C CG2 1 
ATOM 2140 N N   . ASP C 1 45  ? -51.977 -1.213  -55.382 1.00 93.75  ? 243 ASP C N   1 
ATOM 2141 C CA  . ASP C 1 45  ? -51.523 0.030   -55.984 1.00 84.90  ? 243 ASP C CA  1 
ATOM 2142 C C   . ASP C 1 45  ? -50.275 -0.215  -56.830 1.00 86.96  ? 243 ASP C C   1 
ATOM 2143 O O   . ASP C 1 45  ? -49.826 -1.349  -57.017 1.00 91.23  ? 243 ASP C O   1 
ATOM 2144 C CB  . ASP C 1 45  ? -51.253 1.074   -54.903 1.00 92.88  ? 243 ASP C CB  1 
ATOM 2145 C CG  . ASP C 1 45  ? -52.415 1.235   -53.943 1.00 99.65  ? 243 ASP C CG  1 
ATOM 2146 O OD1 . ASP C 1 45  ? -53.425 0.517   -54.104 1.00 108.54 ? 243 ASP C OD1 1 
ATOM 2147 O OD2 . ASP C 1 45  ? -52.319 2.078   -53.027 1.00 103.17 ? 243 ASP C OD2 1 
ATOM 2148 N N   . LYS C 1 46  ? -49.705 0.870   -57.345 1.00 84.68  ? 244 LYS C N   1 
ATOM 2149 C CA  . LYS C 1 46  ? -48.492 0.780   -58.138 1.00 72.42  ? 244 LYS C CA  1 
ATOM 2150 C C   . LYS C 1 46  ? -47.291 0.475   -57.246 1.00 69.10  ? 244 LYS C C   1 
ATOM 2151 O O   . LYS C 1 46  ? -47.340 0.608   -56.019 1.00 77.69  ? 244 LYS C O   1 
ATOM 2152 C CB  . LYS C 1 46  ? -48.256 2.083   -58.904 1.00 77.30  ? 244 LYS C CB  1 
ATOM 2153 C CG  . LYS C 1 46  ? -49.434 2.526   -59.754 1.00 87.03  ? 244 LYS C CG  1 
ATOM 2154 C CD  . LYS C 1 46  ? -49.261 3.959   -60.235 1.00 86.56  ? 244 LYS C CD  1 
ATOM 2155 C CE  . LYS C 1 46  ? -48.004 4.118   -61.074 1.00 96.49  ? 244 LYS C CE  1 
ATOM 2156 N NZ  . LYS C 1 46  ? -47.836 5.517   -61.554 1.00 87.78  ? 244 LYS C NZ  1 
ATOM 2157 N N   . SER C 1 47  ? -46.200 0.061   -57.881 1.00 69.91  ? 245 SER C N   1 
ATOM 2158 C CA  . SER C 1 47  ? -44.971 -0.192  -57.150 1.00 56.18  ? 245 SER C CA  1 
ATOM 2159 C C   . SER C 1 47  ? -44.301 1.127   -56.767 1.00 67.75  ? 245 SER C C   1 
ATOM 2160 O O   . SER C 1 47  ? -44.448 2.132   -57.468 1.00 76.34  ? 245 SER C O   1 
ATOM 2161 C CB  . SER C 1 47  ? -44.015 -1.034  -57.988 1.00 65.14  ? 245 SER C CB  1 
ATOM 2162 O OG  . SER C 1 47  ? -44.564 -2.312  -58.257 1.00 80.28  ? 245 SER C OG  1 
ATOM 2163 N N   . PRO C 1 48  ? -43.571 1.152   -55.653 1.00 65.14  ? 246 PRO C N   1 
ATOM 2164 C CA  . PRO C 1 48  ? -42.896 2.391   -55.249 1.00 61.21  ? 246 PRO C CA  1 
ATOM 2165 C C   . PRO C 1 48  ? -41.785 2.753   -56.221 1.00 58.35  ? 246 PRO C C   1 
ATOM 2166 O O   . PRO C 1 48  ? -41.040 1.890   -56.692 1.00 60.65  ? 246 PRO C O   1 
ATOM 2167 C CB  . PRO C 1 48  ? -42.331 2.059   -53.861 1.00 51.27  ? 246 PRO C CB  1 
ATOM 2168 C CG  . PRO C 1 48  ? -43.048 0.827   -53.425 1.00 59.82  ? 246 PRO C CG  1 
ATOM 2169 C CD  . PRO C 1 48  ? -43.382 0.076   -54.668 1.00 49.93  ? 246 PRO C CD  1 
ATOM 2170 N N   . PHE C 1 49  ? -41.681 4.045   -56.520 1.00 60.75  ? 247 PHE C N   1 
ATOM 2171 C CA  . PHE C 1 49  ? -40.613 4.528   -57.385 1.00 60.38  ? 247 PHE C CA  1 
ATOM 2172 C C   . PHE C 1 49  ? -39.278 4.394   -56.663 1.00 53.82  ? 247 PHE C C   1 
ATOM 2173 O O   . PHE C 1 49  ? -39.071 5.000   -55.607 1.00 62.87  ? 247 PHE C O   1 
ATOM 2174 C CB  . PHE C 1 49  ? -40.867 5.977   -57.789 1.00 58.49  ? 247 PHE C CB  1 
ATOM 2175 C CG  . PHE C 1 49  ? -39.869 6.512   -58.775 1.00 62.12  ? 247 PHE C CG  1 
ATOM 2176 C CD1 . PHE C 1 49  ? -40.033 6.295   -60.133 1.00 62.58  ? 247 PHE C CD1 1 
ATOM 2177 C CD2 . PHE C 1 49  ? -38.764 7.228   -58.344 1.00 65.44  ? 247 PHE C CD2 1 
ATOM 2178 C CE1 . PHE C 1 49  ? -39.115 6.783   -61.043 1.00 66.99  ? 247 PHE C CE1 1 
ATOM 2179 C CE2 . PHE C 1 49  ? -37.843 7.718   -59.249 1.00 67.19  ? 247 PHE C CE2 1 
ATOM 2180 C CZ  . PHE C 1 49  ? -38.019 7.496   -60.600 1.00 63.63  ? 247 PHE C CZ  1 
ATOM 2181 N N   . VAL C 1 50  ? -38.377 3.598   -57.230 1.00 56.18  ? 248 VAL C N   1 
ATOM 2182 C CA  . VAL C 1 50  ? -37.093 3.320   -56.596 1.00 63.00  ? 248 VAL C CA  1 
ATOM 2183 C C   . VAL C 1 50  ? -36.138 4.473   -56.879 1.00 61.99  ? 248 VAL C C   1 
ATOM 2184 O O   . VAL C 1 50  ? -35.892 4.821   -58.038 1.00 67.72  ? 248 VAL C O   1 
ATOM 2185 C CB  . VAL C 1 50  ? -36.511 1.988   -57.088 1.00 61.60  ? 248 VAL C CB  1 
ATOM 2186 C CG1 . VAL C 1 50  ? -35.191 1.698   -56.390 1.00 58.96  ? 248 VAL C CG1 1 
ATOM 2187 C CG2 . VAL C 1 50  ? -37.503 0.859   -56.857 1.00 47.91  ? 248 VAL C CG2 1 
ATOM 2188 N N   . ILE C 1 51  ? -35.601 5.066   -55.818 1.00 59.27  ? 249 ILE C N   1 
ATOM 2189 C CA  . ILE C 1 51  ? -34.595 6.116   -55.912 1.00 64.65  ? 249 ILE C CA  1 
ATOM 2190 C C   . ILE C 1 51  ? -33.268 5.481   -55.518 1.00 72.63  ? 249 ILE C C   1 
ATOM 2191 O O   . ILE C 1 51  ? -32.982 5.296   -54.329 1.00 73.06  ? 249 ILE C O   1 
ATOM 2192 C CB  . ILE C 1 51  ? -34.933 7.318   -55.024 1.00 60.66  ? 249 ILE C CB  1 
ATOM 2193 C CG1 . ILE C 1 51  ? -36.275 7.927   -55.438 1.00 59.91  ? 249 ILE C CG1 1 
ATOM 2194 C CG2 . ILE C 1 51  ? -33.826 8.358   -55.091 1.00 55.65  ? 249 ILE C CG2 1 
ATOM 2195 C CD1 . ILE C 1 51  ? -36.693 9.114   -54.598 1.00 67.59  ? 249 ILE C CD1 1 
ATOM 2196 N N   . TYR C 1 52  ? -32.451 5.139   -56.515 1.00 66.90  ? 250 TYR C N   1 
ATOM 2197 C CA  . TYR C 1 52  ? -31.210 4.417   -56.280 1.00 70.10  ? 250 TYR C CA  1 
ATOM 2198 C C   . TYR C 1 52  ? -29.957 5.214   -56.614 1.00 72.78  ? 250 TYR C C   1 
ATOM 2199 O O   . TYR C 1 52  ? -28.862 4.803   -56.214 1.00 76.49  ? 250 TYR C O   1 
ATOM 2200 C CB  . TYR C 1 52  ? -31.199 3.104   -57.079 1.00 69.82  ? 250 TYR C CB  1 
ATOM 2201 C CG  . TYR C 1 52  ? -31.323 3.284   -58.577 1.00 78.52  ? 250 TYR C CG  1 
ATOM 2202 C CD1 . TYR C 1 52  ? -32.568 3.385   -59.184 1.00 80.57  ? 250 TYR C CD1 1 
ATOM 2203 C CD2 . TYR C 1 52  ? -30.194 3.343   -59.385 1.00 82.90  ? 250 TYR C CD2 1 
ATOM 2204 C CE1 . TYR C 1 52  ? -32.687 3.546   -60.552 1.00 86.95  ? 250 TYR C CE1 1 
ATOM 2205 C CE2 . TYR C 1 52  ? -30.303 3.503   -60.755 1.00 78.39  ? 250 TYR C CE2 1 
ATOM 2206 C CZ  . TYR C 1 52  ? -31.551 3.605   -61.332 1.00 77.76  ? 250 TYR C CZ  1 
ATOM 2207 O OH  . TYR C 1 52  ? -31.664 3.766   -62.694 1.00 66.12  ? 250 TYR C OH  1 
ATOM 2208 N N   . ASP C 1 53  ? -30.077 6.330   -57.327 1.00 76.05  ? 251 ASP C N   1 
ATOM 2209 C CA  . ASP C 1 53  ? -28.910 7.119   -57.702 1.00 82.05  ? 251 ASP C CA  1 
ATOM 2210 C C   . ASP C 1 53  ? -29.353 8.558   -57.937 1.00 78.95  ? 251 ASP C C   1 
ATOM 2211 O O   . ASP C 1 53  ? -30.528 8.902   -57.776 1.00 74.04  ? 251 ASP C O   1 
ATOM 2212 C CB  . ASP C 1 53  ? -28.218 6.525   -58.933 1.00 78.57  ? 251 ASP C CB  1 
ATOM 2213 C CG  . ASP C 1 53  ? -28.780 7.060   -60.234 1.00 83.73  ? 251 ASP C CG  1 
ATOM 2214 O OD1 . ASP C 1 53  ? -28.159 7.978   -60.808 1.00 90.42  ? 251 ASP C OD1 1 
ATOM 2215 O OD2 . ASP C 1 53  ? -29.842 6.575   -60.676 1.00 79.03  ? 251 ASP C OD2 1 
ATOM 2216 N N   . MET C 1 54  ? -28.390 9.403   -58.315 1.00 77.76  ? 252 MET C N   1 
ATOM 2217 C CA  . MET C 1 54  ? -28.686 10.811  -58.561 1.00 78.03  ? 252 MET C CA  1 
ATOM 2218 C C   . MET C 1 54  ? -29.628 10.995  -59.743 1.00 81.99  ? 252 MET C C   1 
ATOM 2219 O O   . MET C 1 54  ? -30.426 11.939  -59.758 1.00 77.57  ? 252 MET C O   1 
ATOM 2220 C CB  . MET C 1 54  ? -27.389 11.584  -58.795 1.00 80.21  ? 252 MET C CB  1 
ATOM 2221 C CG  . MET C 1 54  ? -26.404 11.502  -57.643 1.00 78.65  ? 252 MET C CG  1 
ATOM 2222 S SD  . MET C 1 54  ? -27.081 12.193  -56.124 1.00 81.64  ? 252 MET C SD  1 
ATOM 2223 C CE  . MET C 1 54  ? -27.499 13.842  -56.678 1.00 77.75  ? 252 MET C CE  1 
ATOM 2224 N N   . ASN C 1 55  ? -29.548 10.113  -60.741 1.00 81.60  ? 253 ASN C N   1 
ATOM 2225 C CA  . ASN C 1 55  ? -30.424 10.229  -61.902 1.00 81.76  ? 253 ASN C CA  1 
ATOM 2226 C C   . ASN C 1 55  ? -31.873 9.949   -61.522 1.00 80.29  ? 253 ASN C C   1 
ATOM 2227 O O   . ASN C 1 55  ? -32.774 10.726  -61.857 1.00 76.89  ? 253 ASN C O   1 
ATOM 2228 C CB  . ASN C 1 55  ? -29.961 9.276   -63.005 1.00 80.63  ? 253 ASN C CB  1 
ATOM 2229 C CG  . ASN C 1 55  ? -30.184 9.838   -64.395 1.00 89.28  ? 253 ASN C CG  1 
ATOM 2230 O OD1 . ASN C 1 55  ? -29.269 10.391  -65.005 1.00 104.88 ? 253 ASN C OD1 1 
ATOM 2231 N ND2 . ASN C 1 55  ? -31.402 9.698   -64.903 1.00 87.58  ? 253 ASN C ND2 1 
ATOM 2232 N N   . SER C 1 56  ? -32.112 8.846   -60.807 1.00 78.06  ? 254 SER C N   1 
ATOM 2233 C CA  . SER C 1 56  ? -33.478 8.464   -60.462 1.00 73.68  ? 254 SER C CA  1 
ATOM 2234 C C   . SER C 1 56  ? -34.106 9.425   -59.459 1.00 64.98  ? 254 SER C C   1 
ATOM 2235 O O   . SER C 1 56  ? -35.333 9.570   -59.433 1.00 67.44  ? 254 SER C O   1 
ATOM 2236 C CB  . SER C 1 56  ? -33.500 7.037   -59.915 1.00 70.19  ? 254 SER C CB  1 
ATOM 2237 O OG  . SER C 1 56  ? -32.611 6.895   -58.821 1.00 70.99  ? 254 SER C OG  1 
ATOM 2238 N N   . LEU C 1 57  ? -33.294 10.085  -58.630 1.00 60.99  ? 255 LEU C N   1 
ATOM 2239 C CA  . LEU C 1 57  ? -33.841 11.042  -57.672 1.00 66.56  ? 255 LEU C CA  1 
ATOM 2240 C C   . LEU C 1 57  ? -34.448 12.243  -58.386 1.00 70.15  ? 255 LEU C C   1 
ATOM 2241 O O   . LEU C 1 57  ? -35.638 12.538  -58.231 1.00 76.34  ? 255 LEU C O   1 
ATOM 2242 C CB  . LEU C 1 57  ? -32.757 11.492  -56.692 1.00 62.10  ? 255 LEU C CB  1 
ATOM 2243 C CG  . LEU C 1 57  ? -33.229 12.578  -55.721 1.00 73.69  ? 255 LEU C CG  1 
ATOM 2244 C CD1 . LEU C 1 57  ? -34.340 12.054  -54.822 1.00 68.76  ? 255 LEU C CD1 1 
ATOM 2245 C CD2 . LEU C 1 57  ? -32.076 13.112  -54.897 1.00 78.99  ? 255 LEU C CD2 1 
ATOM 2246 N N   . MET C 1 58  ? -33.637 12.954  -59.174 1.00 76.45  ? 256 MET C N   1 
ATOM 2247 C CA  . MET C 1 58  ? -34.156 14.072  -59.952 1.00 77.16  ? 256 MET C CA  1 
ATOM 2248 C C   . MET C 1 58  ? -35.134 13.618  -61.027 1.00 67.10  ? 256 MET C C   1 
ATOM 2249 O O   . MET C 1 58  ? -35.930 14.432  -61.507 1.00 85.71  ? 256 MET C O   1 
ATOM 2250 C CB  . MET C 1 58  ? -33.002 14.858  -60.576 1.00 76.52  ? 256 MET C CB  1 
ATOM 2251 C CG  . MET C 1 58  ? -32.249 15.729  -59.580 1.00 80.33  ? 256 MET C CG  1 
ATOM 2252 S SD  . MET C 1 58  ? -30.874 16.632  -60.319 1.00 99.65  ? 256 MET C SD  1 
ATOM 2253 C CE  . MET C 1 58  ? -30.464 17.765  -58.993 1.00 78.58  ? 256 MET C CE  1 
ATOM 2254 N N   . MET C 1 59  ? -35.090 12.341  -61.417 1.00 72.91  ? 257 MET C N   1 
ATOM 2255 C CA  . MET C 1 59  ? -36.142 11.793  -62.265 1.00 76.74  ? 257 MET C CA  1 
ATOM 2256 C C   . MET C 1 59  ? -37.448 11.644  -61.496 1.00 83.44  ? 257 MET C C   1 
ATOM 2257 O O   . MET C 1 59  ? -38.531 11.751  -62.084 1.00 84.55  ? 257 MET C O   1 
ATOM 2258 C CB  . MET C 1 59  ? -35.708 10.442  -62.838 1.00 70.91  ? 257 MET C CB  1 
ATOM 2259 C CG  . MET C 1 59  ? -36.745 9.760   -63.719 1.00 85.31  ? 257 MET C CG  1 
ATOM 2260 S SD  . MET C 1 59  ? -36.720 10.335  -65.426 1.00 133.99 ? 257 MET C SD  1 
ATOM 2261 C CE  . MET C 1 59  ? -35.224 9.551   -66.023 1.00 107.69 ? 257 MET C CE  1 
ATOM 2262 N N   . GLY C 1 60  ? -37.368 11.421  -60.185 1.00 73.15  ? 258 GLY C N   1 
ATOM 2263 C CA  . GLY C 1 60  ? -38.543 11.189  -59.366 1.00 69.91  ? 258 GLY C CA  1 
ATOM 2264 C C   . GLY C 1 60  ? -39.464 12.382  -59.209 1.00 73.13  ? 258 GLY C C   1 
ATOM 2265 O O   . GLY C 1 60  ? -39.860 12.725  -58.092 1.00 74.68  ? 258 GLY C O   1 
ATOM 2266 N N   . GLU C 1 61  ? -39.811 13.024  -60.321 1.00 98.16  ? 259 GLU C N   1 
ATOM 2267 C CA  . GLU C 1 61  ? -40.781 14.112  -60.340 1.00 91.93  ? 259 GLU C CA  1 
ATOM 2268 C C   . GLU C 1 61  ? -41.802 13.810  -61.426 1.00 73.10  ? 259 GLU C C   1 
ATOM 2269 O O   . GLU C 1 61  ? -41.435 13.654  -62.595 1.00 72.61  ? 259 GLU C O   1 
ATOM 2270 C CB  . GLU C 1 61  ? -40.104 15.464  -60.591 1.00 80.02  ? 259 GLU C CB  1 
ATOM 2271 C CG  . GLU C 1 61  ? -39.620 16.183  -59.334 1.00 65.86  ? 259 GLU C CG  1 
ATOM 2272 C CD  . GLU C 1 61  ? -38.493 15.454  -58.626 1.00 85.43  ? 259 GLU C CD  1 
ATOM 2273 O OE1 . GLU C 1 61  ? -38.466 15.465  -57.377 1.00 80.77  ? 259 GLU C OE1 1 
ATOM 2274 O OE2 . GLU C 1 61  ? -37.634 14.870  -59.317 1.00 97.51  ? 259 GLU C OE2 1 
ATOM 2275 N N   . ASP C 1 62  ? -43.074 13.730  -61.045 1.00 60.83  ? 260 ASP C N   1 
ATOM 2276 C CA  . ASP C 1 62  ? -43.502 13.987  -59.674 1.00 76.51  ? 260 ASP C CA  1 
ATOM 2277 C C   . ASP C 1 62  ? -43.923 12.700  -58.967 1.00 80.89  ? 260 ASP C C   1 
ATOM 2278 O O   . ASP C 1 62  ? -45.090 12.532  -58.610 1.00 80.80  ? 260 ASP C O   1 
ATOM 2279 C CB  . ASP C 1 62  ? -44.653 14.994  -59.667 1.00 74.22  ? 260 ASP C CB  1 
ATOM 2280 C CG  . ASP C 1 62  ? -44.459 16.096  -58.648 1.00 88.99  ? 260 ASP C CG  1 
ATOM 2281 O OD1 . ASP C 1 62  ? -44.148 15.782  -57.480 1.00 98.68  ? 260 ASP C OD1 1 
ATOM 2282 O OD2 . ASP C 1 62  ? -44.609 17.280  -59.018 1.00 83.03  ? 260 ASP C OD2 1 
ATOM 2283 N N   . LYS C 1 63  ? -42.965 11.795  -58.759 1.00 76.02  ? 261 LYS C N   1 
ATOM 2284 C CA  . LYS C 1 63  ? -43.279 10.507  -58.149 1.00 76.47  ? 261 LYS C CA  1 
ATOM 2285 C C   . LYS C 1 63  ? -43.336 10.600  -56.628 1.00 80.42  ? 261 LYS C C   1 
ATOM 2286 O O   . LYS C 1 63  ? -44.277 10.096  -56.006 1.00 74.09  ? 261 LYS C O   1 
ATOM 2287 C CB  . LYS C 1 63  ? -42.260 9.454   -58.590 1.00 69.37  ? 261 LYS C CB  1 
ATOM 2288 C CG  . LYS C 1 63  ? -42.301 9.144   -60.079 1.00 75.95  ? 261 LYS C CG  1 
ATOM 2289 C CD  . LYS C 1 63  ? -43.692 8.702   -60.509 1.00 79.48  ? 261 LYS C CD  1 
ATOM 2290 C CE  . LYS C 1 63  ? -43.759 8.453   -62.008 1.00 85.61  ? 261 LYS C CE  1 
ATOM 2291 N NZ  . LYS C 1 63  ? -42.842 7.361   -62.436 1.00 85.90  ? 261 LYS C NZ  1 
ATOM 2292 N N   . ILE C 1 64  ? -42.339 11.229  -56.010 1.00 75.18  ? 262 ILE C N   1 
ATOM 2293 C CA  . ILE C 1 64  ? -42.318 11.409  -54.566 1.00 66.88  ? 262 ILE C CA  1 
ATOM 2294 C C   . ILE C 1 64  ? -42.458 12.893  -54.256 1.00 76.95  ? 262 ILE C C   1 
ATOM 2295 O O   . ILE C 1 64  ? -42.274 13.759  -55.117 1.00 73.72  ? 262 ILE C O   1 
ATOM 2296 C CB  . ILE C 1 64  ? -41.045 10.824  -53.914 1.00 64.62  ? 262 ILE C CB  1 
ATOM 2297 C CG1 . ILE C 1 64  ? -39.923 11.867  -53.851 1.00 70.66  ? 262 ILE C CG1 1 
ATOM 2298 C CG2 . ILE C 1 64  ? -40.587 9.581   -54.666 1.00 65.71  ? 262 ILE C CG2 1 
ATOM 2299 C CD1 . ILE C 1 64  ? -39.122 12.005  -55.123 1.00 65.30  ? 262 ILE C CD1 1 
ATOM 2300 N N   . LYS C 1 65  ? -42.802 13.186  -53.003 1.00 79.64  ? 263 LYS C N   1 
ATOM 2301 C CA  . LYS C 1 65  ? -42.973 14.557  -52.545 1.00 83.66  ? 263 LYS C CA  1 
ATOM 2302 C C   . LYS C 1 65  ? -42.256 14.755  -51.220 1.00 91.37  ? 263 LYS C C   1 
ATOM 2303 O O   . LYS C 1 65  ? -42.197 13.842  -50.390 1.00 97.57  ? 263 LYS C O   1 
ATOM 2304 C CB  . LYS C 1 65  ? -44.455 14.921  -52.376 1.00 80.83  ? 263 LYS C CB  1 
ATOM 2305 C CG  . LYS C 1 65  ? -45.297 14.797  -53.633 1.00 82.81  ? 263 LYS C CG  1 
ATOM 2306 C CD  . LYS C 1 65  ? -46.673 15.406  -53.416 1.00 82.43  ? 263 LYS C CD  1 
ATOM 2307 C CE  . LYS C 1 65  ? -47.620 15.065  -54.553 1.00 82.23  ? 263 LYS C CE  1 
ATOM 2308 N NZ  . LYS C 1 65  ? -47.918 13.607  -54.604 1.00 90.42  ? 263 LYS C NZ  1 
ATOM 2309 N N   . PHE C 1 66  ? -41.712 15.952  -51.032 1.00 94.10  ? 264 PHE C N   1 
ATOM 2310 C CA  . PHE C 1 66  ? -41.167 16.382  -49.757 1.00 96.00  ? 264 PHE C CA  1 
ATOM 2311 C C   . PHE C 1 66  ? -42.147 17.345  -49.093 1.00 97.75  ? 264 PHE C C   1 
ATOM 2312 O O   . PHE C 1 66  ? -43.248 17.595  -49.589 1.00 91.62  ? 264 PHE C O   1 
ATOM 2313 C CB  . PHE C 1 66  ? -39.796 17.036  -49.949 1.00 93.04  ? 264 PHE C CB  1 
ATOM 2314 C CG  . PHE C 1 66  ? -38.726 16.088  -50.414 1.00 89.97  ? 264 PHE C CG  1 
ATOM 2315 C CD1 . PHE C 1 66  ? -37.823 16.470  -51.393 1.00 90.46  ? 264 PHE C CD1 1 
ATOM 2316 C CD2 . PHE C 1 66  ? -38.615 14.821  -49.865 1.00 94.05  ? 264 PHE C CD2 1 
ATOM 2317 C CE1 . PHE C 1 66  ? -36.835 15.603  -51.824 1.00 83.36  ? 264 PHE C CE1 1 
ATOM 2318 C CE2 . PHE C 1 66  ? -37.628 13.950  -50.290 1.00 92.10  ? 264 PHE C CE2 1 
ATOM 2319 C CZ  . PHE C 1 66  ? -36.737 14.342  -51.271 1.00 79.61  ? 264 PHE C CZ  1 
ATOM 2320 N N   . LYS C 1 67  ? -41.739 17.894  -47.952 1.00 98.81  ? 265 LYS C N   1 
ATOM 2321 C CA  . LYS C 1 67  ? -42.512 18.911  -47.247 1.00 100.21 ? 265 LYS C CA  1 
ATOM 2322 C C   . LYS C 1 67  ? -41.690 20.191  -47.237 1.00 102.08 ? 265 LYS C C   1 
ATOM 2323 O O   . LYS C 1 67  ? -40.632 20.250  -46.602 1.00 97.33  ? 265 LYS C O   1 
ATOM 2324 C CB  . LYS C 1 67  ? -42.861 18.468  -45.827 1.00 100.82 ? 265 LYS C CB  1 
ATOM 2325 C CG  . LYS C 1 67  ? -43.379 17.044  -45.717 1.00 98.59  ? 265 LYS C CG  1 
ATOM 2326 C CD  . LYS C 1 67  ? -42.255 16.075  -45.385 1.00 89.31  ? 265 LYS C CD  1 
ATOM 2327 C CE  . LYS C 1 67  ? -42.341 14.827  -46.244 1.00 101.79 ? 265 LYS C CE  1 
ATOM 2328 N NZ  . LYS C 1 67  ? -43.574 14.043  -45.964 1.00 104.55 ? 265 LYS C NZ  1 
ATOM 2329 N N   . HIS C 1 68  ? -42.170 21.206  -47.947 1.00 101.70 ? 266 HIS C N   1 
ATOM 2330 C CA  . HIS C 1 68  ? -41.427 22.449  -48.106 1.00 97.26  ? 266 HIS C CA  1 
ATOM 2331 C C   . HIS C 1 68  ? -41.516 23.317  -46.856 1.00 96.04  ? 266 HIS C C   1 
ATOM 2332 O O   . HIS C 1 68  ? -40.825 24.330  -46.743 1.00 101.43 ? 266 HIS C O   1 
ATOM 2333 C CB  . HIS C 1 68  ? -41.942 23.221  -49.323 1.00 102.35 ? 266 HIS C CB  1 
ATOM 2334 C CG  . HIS C 1 68  ? -40.856 23.766  -50.196 1.00 104.59 ? 266 HIS C CG  1 
ATOM 2335 N ND1 . HIS C 1 68  ? -41.084 24.198  -51.485 1.00 101.66 ? 266 HIS C ND1 1 
ATOM 2336 C CD2 . HIS C 1 68  ? -39.534 23.948  -49.966 1.00 108.06 ? 266 HIS C CD2 1 
ATOM 2337 C CE1 . HIS C 1 68  ? -39.950 24.623  -52.011 1.00 99.55  ? 266 HIS C CE1 1 
ATOM 2338 N NE2 . HIS C 1 68  ? -38.994 24.483  -51.111 1.00 109.99 ? 266 HIS C NE2 1 
ATOM 2339 N N   . LYS C 1 77  ? -31.351 24.169  -53.929 1.00 93.82  ? 275 LYS C N   1 
ATOM 2340 C CA  . LYS C 1 77  ? -30.349 23.684  -52.987 1.00 87.79  ? 275 LYS C CA  1 
ATOM 2341 C C   . LYS C 1 77  ? -29.723 22.380  -53.470 1.00 95.76  ? 275 LYS C C   1 
ATOM 2342 O O   . LYS C 1 77  ? -30.199 21.773  -54.429 1.00 100.02 ? 275 LYS C O   1 
ATOM 2343 C CB  . LYS C 1 77  ? -30.969 23.494  -51.600 1.00 94.29  ? 275 LYS C CB  1 
ATOM 2344 C CG  . LYS C 1 77  ? -32.344 22.844  -51.610 1.00 87.67  ? 275 LYS C CG  1 
ATOM 2345 C CD  . LYS C 1 77  ? -33.382 23.763  -50.982 1.00 85.88  ? 275 LYS C CD  1 
ATOM 2346 C CE  . LYS C 1 77  ? -34.741 23.090  -50.882 1.00 85.97  ? 275 LYS C CE  1 
ATOM 2347 N NZ  . LYS C 1 77  ? -35.743 23.967  -50.213 1.00 77.25  ? 275 LYS C NZ  1 
ATOM 2348 N N   . GLU C 1 78  ? -28.651 21.957  -52.806 1.00 92.91  ? 276 GLU C N   1 
ATOM 2349 C CA  . GLU C 1 78  ? -27.998 20.712  -53.176 1.00 91.32  ? 276 GLU C CA  1 
ATOM 2350 C C   . GLU C 1 78  ? -28.790 19.519  -52.650 1.00 93.37  ? 276 GLU C C   1 
ATOM 2351 O O   . GLU C 1 78  ? -29.602 19.634  -51.728 1.00 89.54  ? 276 GLU C O   1 
ATOM 2352 C CB  . GLU C 1 78  ? -26.564 20.663  -52.647 1.00 91.10  ? 276 GLU C CB  1 
ATOM 2353 C CG  . GLU C 1 78  ? -26.454 20.496  -51.141 1.00 93.25  ? 276 GLU C CG  1 
ATOM 2354 C CD  . GLU C 1 78  ? -25.110 19.931  -50.720 1.00 89.52  ? 276 GLU C CD  1 
ATOM 2355 O OE1 . GLU C 1 78  ? -24.485 19.217  -51.531 1.00 90.54  ? 276 GLU C OE1 1 
ATOM 2356 O OE2 . GLU C 1 78  ? -24.677 20.202  -49.580 1.00 99.28  ? 276 GLU C OE2 1 
ATOM 2357 N N   . VAL C 1 79  ? -28.531 18.357  -53.252 1.00 93.07  ? 277 VAL C N   1 
ATOM 2358 C CA  . VAL C 1 79  ? -29.310 17.161  -52.946 1.00 87.44  ? 277 VAL C CA  1 
ATOM 2359 C C   . VAL C 1 79  ? -29.094 16.722  -51.503 1.00 90.85  ? 277 VAL C C   1 
ATOM 2360 O O   . VAL C 1 79  ? -30.043 16.333  -50.812 1.00 87.81  ? 277 VAL C O   1 
ATOM 2361 C CB  . VAL C 1 79  ? -28.965 16.043  -53.947 1.00 83.91  ? 277 VAL C CB  1 
ATOM 2362 C CG1 . VAL C 1 79  ? -29.249 14.674  -53.351 1.00 78.04  ? 277 VAL C CG1 1 
ATOM 2363 C CG2 . VAL C 1 79  ? -29.748 16.239  -55.237 1.00 83.73  ? 277 VAL C CG2 1 
ATOM 2364 N N   . ALA C 1 80  ? -27.850 16.785  -51.019 1.00 95.94  ? 278 ALA C N   1 
ATOM 2365 C CA  . ALA C 1 80  ? -27.563 16.333  -49.660 1.00 89.66  ? 278 ALA C CA  1 
ATOM 2366 C C   . ALA C 1 80  ? -28.344 17.138  -48.628 1.00 86.64  ? 278 ALA C C   1 
ATOM 2367 O O   . ALA C 1 80  ? -28.884 16.574  -47.670 1.00 84.54  ? 278 ALA C O   1 
ATOM 2368 C CB  . ALA C 1 80  ? -26.061 16.416  -49.387 1.00 90.07  ? 278 ALA C CB  1 
ATOM 2369 N N   . ILE C 1 81  ? -28.420 18.457  -48.808 1.00 93.48  ? 279 ILE C N   1 
ATOM 2370 C CA  . ILE C 1 81  ? -29.188 19.283  -47.884 1.00 90.31  ? 279 ILE C CA  1 
ATOM 2371 C C   . ILE C 1 81  ? -30.682 19.185  -48.177 1.00 96.48  ? 279 ILE C C   1 
ATOM 2372 O O   . ILE C 1 81  ? -31.503 19.229  -47.252 1.00 97.05  ? 279 ILE C O   1 
ATOM 2373 C CB  . ILE C 1 81  ? -28.693 20.739  -47.941 1.00 90.74  ? 279 ILE C CB  1 
ATOM 2374 C CG1 . ILE C 1 81  ? -27.211 20.811  -47.571 1.00 92.42  ? 279 ILE C CG1 1 
ATOM 2375 C CG2 . ILE C 1 81  ? -29.510 21.629  -47.012 1.00 78.57  ? 279 ILE C CG2 1 
ATOM 2376 C CD1 . ILE C 1 81  ? -26.629 22.210  -47.637 1.00 105.88 ? 279 ILE C CD1 1 
ATOM 2377 N N   . ARG C 1 82  ? -31.058 19.038  -49.450 1.00 94.49  ? 280 ARG C N   1 
ATOM 2378 C CA  . ARG C 1 82  ? -32.473 18.964  -49.806 1.00 92.22  ? 280 ARG C CA  1 
ATOM 2379 C C   . ARG C 1 82  ? -33.130 17.721  -49.215 1.00 94.74  ? 280 ARG C C   1 
ATOM 2380 O O   . ARG C 1 82  ? -34.297 17.761  -48.807 1.00 95.53  ? 280 ARG C O   1 
ATOM 2381 C CB  . ARG C 1 82  ? -32.625 18.994  -51.328 1.00 94.96  ? 280 ARG C CB  1 
ATOM 2382 C CG  . ARG C 1 82  ? -34.031 18.751  -51.847 1.00 90.96  ? 280 ARG C CG  1 
ATOM 2383 C CD  . ARG C 1 82  ? -34.158 19.237  -53.286 1.00 87.75  ? 280 ARG C CD  1 
ATOM 2384 N NE  . ARG C 1 82  ? -34.903 18.306  -54.129 1.00 116.08 ? 280 ARG C NE  1 
ATOM 2385 C CZ  . ARG C 1 82  ? -34.340 17.455  -54.982 1.00 104.61 ? 280 ARG C CZ  1 
ATOM 2386 N NH1 . ARG C 1 82  ? -35.095 16.644  -55.710 1.00 84.15  ? 280 ARG C NH1 1 
ATOM 2387 N NH2 . ARG C 1 82  ? -33.020 17.418  -55.109 1.00 93.97  ? 280 ARG C NH2 1 
ATOM 2388 N N   . ILE C 1 83  ? -32.394 16.610  -49.151 1.00 85.45  ? 281 ILE C N   1 
ATOM 2389 C CA  . ILE C 1 83  ? -32.941 15.397  -48.552 1.00 81.38  ? 281 ILE C CA  1 
ATOM 2390 C C   . ILE C 1 83  ? -33.009 15.535  -47.036 1.00 94.76  ? 281 ILE C C   1 
ATOM 2391 O O   . ILE C 1 83  ? -33.972 15.088  -46.400 1.00 98.50  ? 281 ILE C O   1 
ATOM 2392 C CB  . ILE C 1 83  ? -32.112 14.171  -48.977 1.00 83.15  ? 281 ILE C CB  1 
ATOM 2393 C CG1 . ILE C 1 83  ? -32.232 13.942  -50.485 1.00 75.66  ? 281 ILE C CG1 1 
ATOM 2394 C CG2 . ILE C 1 83  ? -32.552 12.929  -48.214 1.00 84.47  ? 281 ILE C CG2 1 
ATOM 2395 C CD1 . ILE C 1 83  ? -31.460 12.741  -50.984 1.00 74.69  ? 281 ILE C CD1 1 
ATOM 2396 N N   . PHE C 1 84  ? -31.996 16.162  -46.432 1.00 95.95  ? 282 PHE C N   1 
ATOM 2397 C CA  . PHE C 1 84  ? -31.990 16.329  -44.982 1.00 90.98  ? 282 PHE C CA  1 
ATOM 2398 C C   . PHE C 1 84  ? -33.099 17.270  -44.529 1.00 94.27  ? 282 PHE C C   1 
ATOM 2399 O O   . PHE C 1 84  ? -33.735 17.036  -43.494 1.00 99.55  ? 282 PHE C O   1 
ATOM 2400 C CB  . PHE C 1 84  ? -30.626 16.841  -44.518 1.00 96.56  ? 282 PHE C CB  1 
ATOM 2401 C CG  . PHE C 1 84  ? -30.396 16.701  -43.040 1.00 92.24  ? 282 PHE C CG  1 
ATOM 2402 C CD1 . PHE C 1 84  ? -29.796 15.564  -42.526 1.00 91.59  ? 282 PHE C CD1 1 
ATOM 2403 C CD2 . PHE C 1 84  ? -30.778 17.705  -42.165 1.00 91.18  ? 282 PHE C CD2 1 
ATOM 2404 C CE1 . PHE C 1 84  ? -29.581 15.429  -41.168 1.00 90.47  ? 282 PHE C CE1 1 
ATOM 2405 C CE2 . PHE C 1 84  ? -30.567 17.576  -40.805 1.00 92.53  ? 282 PHE C CE2 1 
ATOM 2406 C CZ  . PHE C 1 84  ? -29.967 16.436  -40.306 1.00 88.33  ? 282 PHE C CZ  1 
ATOM 2407 N N   . GLN C 1 85  ? -33.346 18.340  -45.289 1.00 93.79  ? 283 GLN C N   1 
ATOM 2408 C CA  . GLN C 1 85  ? -34.431 19.253  -44.946 1.00 92.67  ? 283 GLN C CA  1 
ATOM 2409 C C   . GLN C 1 85  ? -35.792 18.591  -45.113 1.00 99.07  ? 283 GLN C C   1 
ATOM 2410 O O   . GLN C 1 85  ? -36.754 18.976  -44.438 1.00 106.98 ? 283 GLN C O   1 
ATOM 2411 C CB  . GLN C 1 85  ? -34.346 20.518  -45.800 1.00 86.96  ? 283 GLN C CB  1 
ATOM 2412 N N   . GLY C 1 86  ? -35.894 17.600  -46.002 1.00 98.98  ? 284 GLY C N   1 
ATOM 2413 C CA  . GLY C 1 86  ? -37.148 16.887  -46.163 1.00 95.57  ? 284 GLY C CA  1 
ATOM 2414 C C   . GLY C 1 86  ? -37.485 16.003  -44.980 1.00 106.88 ? 284 GLY C C   1 
ATOM 2415 O O   . GLY C 1 86  ? -38.660 15.843  -44.637 1.00 104.17 ? 284 GLY C O   1 
ATOM 2416 N N   . CYS C 1 87  ? -36.470 15.420  -44.341 1.00 103.85 ? 285 CYS C N   1 
ATOM 2417 C CA  . CYS C 1 87  ? -36.685 14.583  -43.168 1.00 97.27  ? 285 CYS C CA  1 
ATOM 2418 C C   . CYS C 1 87  ? -36.961 15.388  -41.906 1.00 97.53  ? 285 CYS C C   1 
ATOM 2419 O O   . CYS C 1 87  ? -37.424 14.812  -40.915 1.00 96.36  ? 285 CYS C O   1 
ATOM 2420 C CB  . CYS C 1 87  ? -35.475 13.673  -42.940 1.00 99.75  ? 285 CYS C CB  1 
ATOM 2421 S SG  . CYS C 1 87  ? -35.198 12.458  -44.249 1.00 100.92 ? 285 CYS C SG  1 
ATOM 2422 N N   . GLN C 1 88  ? -36.685 16.693  -41.912 1.00 104.05 ? 286 GLN C N   1 
ATOM 2423 C CA  . GLN C 1 88  ? -36.996 17.522  -40.752 1.00 98.26  ? 286 GLN C CA  1 
ATOM 2424 C C   . GLN C 1 88  ? -38.501 17.705  -40.604 1.00 95.56  ? 286 GLN C C   1 
ATOM 2425 O O   . GLN C 1 88  ? -39.067 17.448  -39.535 1.00 97.46  ? 286 GLN C O   1 
ATOM 2426 C CB  . GLN C 1 88  ? -36.293 18.875  -40.869 1.00 99.77  ? 286 GLN C CB  1 
ATOM 2427 N N   . PHE C 1 89  ? -39.169 18.147  -41.672 1.00 94.93  ? 287 PHE C N   1 
ATOM 2428 C CA  . PHE C 1 89  ? -40.620 18.269  -41.645 1.00 95.48  ? 287 PHE C CA  1 
ATOM 2429 C C   . PHE C 1 89  ? -41.310 16.914  -41.549 1.00 96.93  ? 287 PHE C C   1 
ATOM 2430 O O   . PHE C 1 89  ? -42.474 16.854  -41.138 1.00 94.07  ? 287 PHE C O   1 
ATOM 2431 C CB  . PHE C 1 89  ? -41.103 19.024  -42.883 1.00 109.16 ? 287 PHE C CB  1 
ATOM 2432 C CG  . PHE C 1 89  ? -41.746 20.349  -42.578 1.00 109.36 ? 287 PHE C CG  1 
ATOM 2433 C CD1 . PHE C 1 89  ? -42.569 20.498  -41.475 1.00 102.78 ? 287 PHE C CD1 1 
ATOM 2434 C CD2 . PHE C 1 89  ? -41.524 21.446  -43.395 1.00 106.81 ? 287 PHE C CD2 1 
ATOM 2435 C CE1 . PHE C 1 89  ? -43.162 21.715  -41.192 1.00 96.97  ? 287 PHE C CE1 1 
ATOM 2436 C CE2 . PHE C 1 89  ? -42.114 22.667  -43.118 1.00 110.05 ? 287 PHE C CE2 1 
ATOM 2437 C CZ  . PHE C 1 89  ? -42.934 22.801  -42.014 1.00 112.31 ? 287 PHE C CZ  1 
ATOM 2438 N N   . ARG C 1 90  ? -40.625 15.830  -41.928 1.00 102.73 ? 288 ARG C N   1 
ATOM 2439 C CA  . ARG C 1 90  ? -41.165 14.494  -41.696 1.00 103.56 ? 288 ARG C CA  1 
ATOM 2440 C C   . ARG C 1 90  ? -41.426 14.266  -40.214 1.00 100.10 ? 288 ARG C C   1 
ATOM 2441 O O   . ARG C 1 90  ? -42.474 13.734  -39.830 1.00 81.38  ? 288 ARG C O   1 
ATOM 2442 C CB  . ARG C 1 90  ? -40.198 13.436  -42.230 1.00 97.87  ? 288 ARG C CB  1 
ATOM 2443 C CG  . ARG C 1 90  ? -40.262 13.219  -43.729 1.00 104.32 ? 288 ARG C CG  1 
ATOM 2444 C CD  . ARG C 1 90  ? -41.176 12.059  -44.078 1.00 103.21 ? 288 ARG C CD  1 
ATOM 2445 N NE  . ARG C 1 90  ? -41.273 11.869  -45.521 1.00 102.70 ? 288 ARG C NE  1 
ATOM 2446 C CZ  . ARG C 1 90  ? -40.409 11.165  -46.243 1.00 95.40  ? 288 ARG C CZ  1 
ATOM 2447 N NH1 . ARG C 1 90  ? -39.375 10.575  -45.659 1.00 85.20  ? 288 ARG C NH1 1 
ATOM 2448 N NH2 . ARG C 1 90  ? -40.579 11.053  -47.553 1.00 90.06  ? 288 ARG C NH2 1 
ATOM 2449 N N   . SER C 1 91  ? -40.485 14.679  -39.366 1.00 89.46  ? 289 SER C N   1 
ATOM 2450 C CA  . SER C 1 91  ? -40.609 14.521  -37.925 1.00 82.38  ? 289 SER C CA  1 
ATOM 2451 C C   . SER C 1 91  ? -41.595 15.499  -37.301 1.00 84.27  ? 289 SER C C   1 
ATOM 2452 O O   . SER C 1 91  ? -41.944 15.330  -36.130 1.00 81.44  ? 289 SER C O   1 
ATOM 2453 C CB  . SER C 1 91  ? -39.236 14.681  -37.266 1.00 80.88  ? 289 SER C CB  1 
ATOM 2454 O OG  . SER C 1 91  ? -38.296 13.776  -37.821 1.00 84.58  ? 289 SER C OG  1 
ATOM 2455 N N   . VAL C 1 92  ? -42.052 16.507  -38.046 1.00 84.05  ? 290 VAL C N   1 
ATOM 2456 C CA  . VAL C 1 92  ? -43.010 17.463  -37.499 1.00 78.05  ? 290 VAL C CA  1 
ATOM 2457 C C   . VAL C 1 92  ? -44.408 16.859  -37.452 1.00 75.66  ? 290 VAL C C   1 
ATOM 2458 O O   . VAL C 1 92  ? -45.072 16.877  -36.409 1.00 69.27  ? 290 VAL C O   1 
ATOM 2459 C CB  . VAL C 1 92  ? -42.984 18.773  -38.309 1.00 82.86  ? 290 VAL C CB  1 
ATOM 2460 C CG1 . VAL C 1 92  ? -44.090 19.703  -37.841 1.00 80.58  ? 290 VAL C CG1 1 
ATOM 2461 C CG2 . VAL C 1 92  ? -41.626 19.450  -38.176 1.00 82.79  ? 290 VAL C CG2 1 
ATOM 2462 N N   . GLU C 1 93  ? -44.880 16.315  -38.579 1.00 82.66  ? 291 GLU C N   1 
ATOM 2463 C CA  . GLU C 1 93  ? -46.168 15.627  -38.574 1.00 78.97  ? 291 GLU C CA  1 
ATOM 2464 C C   . GLU C 1 93  ? -46.127 14.377  -37.705 1.00 69.54  ? 291 GLU C C   1 
ATOM 2465 O O   . GLU C 1 93  ? -47.148 13.992  -37.123 1.00 55.45  ? 291 GLU C O   1 
ATOM 2466 C CB  . GLU C 1 93  ? -46.591 15.261  -39.999 1.00 76.78  ? 291 GLU C CB  1 
ATOM 2467 C CG  . GLU C 1 93  ? -47.165 16.406  -40.826 1.00 84.92  ? 291 GLU C CG  1 
ATOM 2468 C CD  . GLU C 1 93  ? -46.101 17.192  -41.567 1.00 91.57  ? 291 GLU C CD  1 
ATOM 2469 O OE1 . GLU C 1 93  ? -46.172 17.270  -42.811 1.00 98.14  ? 291 GLU C OE1 1 
ATOM 2470 O OE2 . GLU C 1 93  ? -45.188 17.730  -40.911 1.00 95.58  ? 291 GLU C OE2 1 
ATOM 2471 N N   . ALA C 1 94  ? -44.962 13.732  -37.606 1.00 61.67  ? 292 ALA C N   1 
ATOM 2472 C CA  . ALA C 1 94  ? -44.833 12.568  -36.736 1.00 64.94  ? 292 ALA C CA  1 
ATOM 2473 C C   . ALA C 1 94  ? -45.033 12.949  -35.276 1.00 57.40  ? 292 ALA C C   1 
ATOM 2474 O O   . ALA C 1 94  ? -45.590 12.169  -34.496 1.00 57.64  ? 292 ALA C O   1 
ATOM 2475 C CB  . ALA C 1 94  ? -43.469 11.909  -36.937 1.00 63.47  ? 292 ALA C CB  1 
ATOM 2476 N N   . VAL C 1 95  ? -44.582 14.146  -34.887 1.00 66.17  ? 293 VAL C N   1 
ATOM 2477 C CA  . VAL C 1 95  ? -44.791 14.614  -33.518 1.00 57.82  ? 293 VAL C CA  1 
ATOM 2478 C C   . VAL C 1 95  ? -46.279 14.699  -33.206 1.00 56.90  ? 293 VAL C C   1 
ATOM 2479 O O   . VAL C 1 95  ? -46.730 14.271  -32.136 1.00 57.53  ? 293 VAL C O   1 
ATOM 2480 C CB  . VAL C 1 95  ? -44.088 15.968  -33.299 1.00 69.64  ? 293 VAL C CB  1 
ATOM 2481 C CG1 . VAL C 1 95  ? -44.668 16.681  -32.090 1.00 60.50  ? 293 VAL C CG1 1 
ATOM 2482 C CG2 . VAL C 1 95  ? -42.594 15.769  -33.116 1.00 67.56  ? 293 VAL C CG2 1 
ATOM 2483 N N   . GLN C 1 96  ? -47.068 15.240  -34.137 1.00 65.64  ? 294 GLN C N   1 
ATOM 2484 C CA  . GLN C 1 96  ? -48.500 15.388  -33.894 1.00 68.59  ? 294 GLN C CA  1 
ATOM 2485 C C   . GLN C 1 96  ? -49.199 14.036  -33.830 1.00 67.31  ? 294 GLN C C   1 
ATOM 2486 O O   . GLN C 1 96  ? -50.110 13.842  -33.016 1.00 69.67  ? 294 GLN C O   1 
ATOM 2487 C CB  . GLN C 1 96  ? -49.128 16.266  -34.976 1.00 76.13  ? 294 GLN C CB  1 
ATOM 2488 C CG  . GLN C 1 96  ? -48.619 17.694  -34.981 1.00 75.93  ? 294 GLN C CG  1 
ATOM 2489 C CD  . GLN C 1 96  ? -49.491 18.617  -35.806 1.00 87.39  ? 294 GLN C CD  1 
ATOM 2490 O OE1 . GLN C 1 96  ? -50.215 18.176  -36.698 1.00 83.81  ? 294 GLN C OE1 1 
ATOM 2491 N NE2 . GLN C 1 96  ? -49.434 19.908  -35.503 1.00 95.15  ? 294 GLN C NE2 1 
ATOM 2492 N N   . GLU C 1 97  ? -48.792 13.090  -34.679 1.00 58.67  ? 295 GLU C N   1 
ATOM 2493 C CA  . GLU C 1 97  ? -49.412 11.769  -34.662 1.00 61.73  ? 295 GLU C CA  1 
ATOM 2494 C C   . GLU C 1 97  ? -49.088 11.023  -33.374 1.00 58.43  ? 295 GLU C C   1 
ATOM 2495 O O   . GLU C 1 97  ? -49.975 10.416  -32.762 1.00 55.08  ? 295 GLU C O   1 
ATOM 2496 C CB  . GLU C 1 97  ? -48.961 10.963  -35.879 1.00 70.26  ? 295 GLU C CB  1 
ATOM 2497 C CG  . GLU C 1 97  ? -49.331 11.593  -37.210 1.00 62.97  ? 295 GLU C CG  1 
ATOM 2498 C CD  . GLU C 1 97  ? -48.785 10.820  -38.393 1.00 60.54  ? 295 GLU C CD  1 
ATOM 2499 O OE1 . GLU C 1 97  ? -48.103 9.797   -38.174 1.00 59.79  ? 295 GLU C OE1 1 
ATOM 2500 O OE2 . GLU C 1 97  ? -49.038 11.235  -39.544 1.00 80.61  ? 295 GLU C OE2 1 
ATOM 2501 N N   . ILE C 1 98  ? -47.823 11.054  -32.951 1.00 58.18  ? 296 ILE C N   1 
ATOM 2502 C CA  . ILE C 1 98  ? -47.437 10.403  -31.704 1.00 49.20  ? 296 ILE C CA  1 
ATOM 2503 C C   . ILE C 1 98  ? -48.116 11.075  -30.518 1.00 60.46  ? 296 ILE C C   1 
ATOM 2504 O O   . ILE C 1 98  ? -48.567 10.405  -29.581 1.00 55.62  ? 296 ILE C O   1 
ATOM 2505 C CB  . ILE C 1 98  ? -45.904 10.405  -31.561 1.00 42.57  ? 296 ILE C CB  1 
ATOM 2506 C CG1 . ILE C 1 98  ? -45.267 9.601   -32.696 1.00 42.25  ? 296 ILE C CG1 1 
ATOM 2507 C CG2 . ILE C 1 98  ? -45.487 9.845   -30.208 1.00 53.22  ? 296 ILE C CG2 1 
ATOM 2508 C CD1 . ILE C 1 98  ? -43.794 9.877   -32.888 1.00 49.23  ? 296 ILE C CD1 1 
ATOM 2509 N N   . THR C 1 99  ? -48.211 12.406  -30.542 1.00 56.97  ? 297 THR C N   1 
ATOM 2510 C CA  . THR C 1 99  ? -48.872 13.116  -29.453 1.00 48.44  ? 297 THR C CA  1 
ATOM 2511 C C   . THR C 1 99  ? -50.364 12.809  -29.419 1.00 55.26  ? 297 THR C C   1 
ATOM 2512 O O   . THR C 1 99  ? -50.949 12.662  -28.340 1.00 61.74  ? 297 THR C O   1 
ATOM 2513 C CB  . THR C 1 99  ? -48.639 14.620  -29.586 1.00 44.72  ? 297 THR C CB  1 
ATOM 2514 O OG1 . THR C 1 99  ? -47.238 14.875  -29.746 1.00 57.15  ? 297 THR C OG1 1 
ATOM 2515 C CG2 . THR C 1 99  ? -49.130 15.332  -28.346 1.00 67.89  ? 297 THR C CG2 1 
ATOM 2516 N N   . GLU C 1 100 ? -50.996 12.707  -30.591 1.00 62.50  ? 298 GLU C N   1 
ATOM 2517 C CA  . GLU C 1 100 ? -52.406 12.338  -30.640 1.00 64.51  ? 298 GLU C CA  1 
ATOM 2518 C C   . GLU C 1 100 ? -52.626 10.923  -30.123 1.00 62.41  ? 298 GLU C C   1 
ATOM 2519 O O   . GLU C 1 100 ? -53.675 10.631  -29.537 1.00 58.79  ? 298 GLU C O   1 
ATOM 2520 C CB  . GLU C 1 100 ? -52.932 12.474  -32.069 1.00 66.84  ? 298 GLU C CB  1 
ATOM 2521 C CG  . GLU C 1 100 ? -54.447 12.439  -32.193 1.00 69.78  ? 298 GLU C CG  1 
ATOM 2522 C CD  . GLU C 1 100 ? -55.120 13.573  -31.445 1.00 82.47  ? 298 GLU C CD  1 
ATOM 2523 O OE1 . GLU C 1 100 ? -55.458 13.387  -30.257 1.00 85.59  ? 298 GLU C OE1 1 
ATOM 2524 O OE2 . GLU C 1 100 ? -55.302 14.655  -32.042 1.00 84.84  ? 298 GLU C OE2 1 
ATOM 2525 N N   . TYR C 1 101 ? -51.649 10.036  -30.324 1.00 61.99  ? 299 TYR C N   1 
ATOM 2526 C CA  . TYR C 1 101 ? -51.760 8.679   -29.800 1.00 59.79  ? 299 TYR C CA  1 
ATOM 2527 C C   . TYR C 1 101 ? -51.544 8.649   -28.292 1.00 57.67  ? 299 TYR C C   1 
ATOM 2528 O O   . TYR C 1 101 ? -52.172 7.851   -27.586 1.00 59.76  ? 299 TYR C O   1 
ATOM 2529 C CB  . TYR C 1 101 ? -50.758 7.764   -30.506 1.00 54.92  ? 299 TYR C CB  1 
ATOM 2530 C CG  . TYR C 1 101 ? -50.630 6.392   -29.882 1.00 52.82  ? 299 TYR C CG  1 
ATOM 2531 C CD1 . TYR C 1 101 ? -51.560 5.397   -30.149 1.00 52.20  ? 299 TYR C CD1 1 
ATOM 2532 C CD2 . TYR C 1 101 ? -49.574 6.091   -29.030 1.00 45.51  ? 299 TYR C CD2 1 
ATOM 2533 C CE1 . TYR C 1 101 ? -51.446 4.142   -29.581 1.00 49.06  ? 299 TYR C CE1 1 
ATOM 2534 C CE2 . TYR C 1 101 ? -49.453 4.840   -28.458 1.00 51.95  ? 299 TYR C CE2 1 
ATOM 2535 C CZ  . TYR C 1 101 ? -50.390 3.869   -28.737 1.00 53.52  ? 299 TYR C CZ  1 
ATOM 2536 O OH  . TYR C 1 101 ? -50.271 2.622   -28.170 1.00 51.54  ? 299 TYR C OH  1 
ATOM 2537 N N   . ALA C 1 102 ? -50.656 9.507   -27.781 1.00 57.89  ? 300 ALA C N   1 
ATOM 2538 C CA  . ALA C 1 102 ? -50.375 9.519   -26.349 1.00 59.58  ? 300 ALA C CA  1 
ATOM 2539 C C   . ALA C 1 102 ? -51.597 9.923   -25.539 1.00 58.95  ? 300 ALA C C   1 
ATOM 2540 O O   . ALA C 1 102 ? -51.782 9.446   -24.413 1.00 60.65  ? 300 ALA C O   1 
ATOM 2541 C CB  . ALA C 1 102 ? -49.206 10.458  -26.051 1.00 56.69  ? 300 ALA C CB  1 
ATOM 2542 N N   . LYS C 1 103 ? -52.442 10.796  -26.092 1.00 62.61  ? 301 LYS C N   1 
ATOM 2543 C CA  . LYS C 1 103 ? -53.652 11.222  -25.399 1.00 64.46  ? 301 LYS C CA  1 
ATOM 2544 C C   . LYS C 1 103 ? -54.633 10.076  -25.189 1.00 65.80  ? 301 LYS C C   1 
ATOM 2545 O O   . LYS C 1 103 ? -55.464 10.147  -24.277 1.00 67.48  ? 301 LYS C O   1 
ATOM 2546 C CB  . LYS C 1 103 ? -54.319 12.355  -26.179 1.00 59.34  ? 301 LYS C CB  1 
ATOM 2547 C CG  . LYS C 1 103 ? -53.417 13.565  -26.373 1.00 71.24  ? 301 LYS C CG  1 
ATOM 2548 C CD  . LYS C 1 103 ? -53.827 14.393  -27.581 1.00 76.56  ? 301 LYS C CD  1 
ATOM 2549 C CE  . LYS C 1 103 ? -55.206 15.003  -27.405 1.00 80.59  ? 301 LYS C CE  1 
ATOM 2550 N NZ  . LYS C 1 103 ? -55.580 15.847  -28.574 1.00 72.45  ? 301 LYS C NZ  1 
ATOM 2551 N N   . SER C 1 104 ? -54.553 9.026   -26.005 1.00 65.68  ? 302 SER C N   1 
ATOM 2552 C CA  . SER C 1 104 ? -55.432 7.873   -25.865 1.00 57.06  ? 302 SER C CA  1 
ATOM 2553 C C   . SER C 1 104 ? -54.944 6.874   -24.825 1.00 63.49  ? 302 SER C C   1 
ATOM 2554 O O   . SER C 1 104 ? -55.701 5.969   -24.458 1.00 58.56  ? 302 SER C O   1 
ATOM 2555 C CB  . SER C 1 104 ? -55.584 7.169   -27.213 1.00 59.89  ? 302 SER C CB  1 
ATOM 2556 O OG  . SER C 1 104 ? -54.321 6.767   -27.712 1.00 71.07  ? 302 SER C OG  1 
ATOM 2557 N N   . ILE C 1 105 ? -53.711 7.008   -24.352 1.00 59.37  ? 303 ILE C N   1 
ATOM 2558 C CA  . ILE C 1 105 ? -53.200 6.096   -23.323 1.00 57.43  ? 303 ILE C CA  1 
ATOM 2559 C C   . ILE C 1 105 ? -53.950 6.348   -22.019 1.00 58.92  ? 303 ILE C C   1 
ATOM 2560 O O   . ILE C 1 105 ? -54.029 7.505   -21.568 1.00 60.96  ? 303 ILE C O   1 
ATOM 2561 C CB  . ILE C 1 105 ? -51.694 6.291   -23.140 1.00 56.79  ? 303 ILE C CB  1 
ATOM 2562 C CG1 . ILE C 1 105 ? -50.964 6.051   -24.464 1.00 50.84  ? 303 ILE C CG1 1 
ATOM 2563 C CG2 . ILE C 1 105 ? -51.162 5.360   -22.061 1.00 49.39  ? 303 ILE C CG2 1 
ATOM 2564 C CD1 . ILE C 1 105 ? -49.468 6.261   -24.385 1.00 52.22  ? 303 ILE C CD1 1 
ATOM 2565 N N   . PRO C 1 106 ? -54.523 5.322   -21.391 1.00 53.51  ? 304 PRO C N   1 
ATOM 2566 C CA  . PRO C 1 106 ? -55.301 5.540   -20.161 1.00 53.97  ? 304 PRO C CA  1 
ATOM 2567 C C   . PRO C 1 106 ? -54.440 6.129   -19.055 1.00 53.30  ? 304 PRO C C   1 
ATOM 2568 O O   . PRO C 1 106 ? -53.421 5.556   -18.662 1.00 56.82  ? 304 PRO C O   1 
ATOM 2569 C CB  . PRO C 1 106 ? -55.799 4.134   -19.806 1.00 50.48  ? 304 PRO C CB  1 
ATOM 2570 C CG  . PRO C 1 106 ? -55.757 3.378   -21.094 1.00 50.60  ? 304 PRO C CG  1 
ATOM 2571 C CD  . PRO C 1 106 ? -54.574 3.919   -21.836 1.00 52.44  ? 304 PRO C CD  1 
ATOM 2572 N N   . GLY C 1 107 ? -54.860 7.290   -18.554 1.00 61.88  ? 305 GLY C N   1 
ATOM 2573 C CA  . GLY C 1 107 ? -54.158 7.971   -17.490 1.00 49.87  ? 305 GLY C CA  1 
ATOM 2574 C C   . GLY C 1 107 ? -53.137 8.992   -17.941 1.00 59.47  ? 305 GLY C C   1 
ATOM 2575 O O   . GLY C 1 107 ? -52.589 9.709   -17.093 1.00 65.92  ? 305 GLY C O   1 
ATOM 2576 N N   . PHE C 1 108 ? -52.862 9.086   -19.244 1.00 59.50  ? 306 PHE C N   1 
ATOM 2577 C CA  . PHE C 1 108 ? -51.864 10.040  -19.716 1.00 58.63  ? 306 PHE C CA  1 
ATOM 2578 C C   . PHE C 1 108 ? -52.388 11.469  -19.653 1.00 59.59  ? 306 PHE C C   1 
ATOM 2579 O O   . PHE C 1 108 ? -51.655 12.388  -19.266 1.00 56.84  ? 306 PHE C O   1 
ATOM 2580 C CB  . PHE C 1 108 ? -51.431 9.688   -21.139 1.00 58.86  ? 306 PHE C CB  1 
ATOM 2581 C CG  . PHE C 1 108 ? -50.347 10.577  -21.681 1.00 60.54  ? 306 PHE C CG  1 
ATOM 2582 C CD1 . PHE C 1 108 ? -49.015 10.301  -21.422 1.00 47.33  ? 306 PHE C CD1 1 
ATOM 2583 C CD2 . PHE C 1 108 ? -50.659 11.688  -22.449 1.00 49.08  ? 306 PHE C CD2 1 
ATOM 2584 C CE1 . PHE C 1 108 ? -48.014 11.117  -21.917 1.00 61.04  ? 306 PHE C CE1 1 
ATOM 2585 C CE2 . PHE C 1 108 ? -49.663 12.507  -22.946 1.00 53.14  ? 306 PHE C CE2 1 
ATOM 2586 C CZ  . PHE C 1 108 ? -48.339 12.221  -22.680 1.00 54.01  ? 306 PHE C CZ  1 
ATOM 2587 N N   . VAL C 1 109 ? -53.651 11.680  -20.033 1.00 63.19  ? 307 VAL C N   1 
ATOM 2588 C CA  . VAL C 1 109 ? -54.212 13.025  -20.022 1.00 72.12  ? 307 VAL C CA  1 
ATOM 2589 C C   . VAL C 1 109 ? -54.458 13.526  -18.606 1.00 73.86  ? 307 VAL C C   1 
ATOM 2590 O O   . VAL C 1 109 ? -54.583 14.738  -18.396 1.00 76.77  ? 307 VAL C O   1 
ATOM 2591 C CB  . VAL C 1 109 ? -55.513 13.075  -20.846 1.00 71.01  ? 307 VAL C CB  1 
ATOM 2592 C CG1 . VAL C 1 109 ? -55.223 12.787  -22.311 1.00 64.46  ? 307 VAL C CG1 1 
ATOM 2593 C CG2 . VAL C 1 109 ? -56.531 12.090  -20.293 1.00 58.96  ? 307 VAL C CG2 1 
ATOM 2594 N N   . ASN C 1 110 ? -54.528 12.626  -17.624 1.00 67.54  ? 308 ASN C N   1 
ATOM 2595 C CA  . ASN C 1 110 ? -54.735 13.026  -16.239 1.00 61.44  ? 308 ASN C CA  1 
ATOM 2596 C C   . ASN C 1 110 ? -53.444 13.415  -15.533 1.00 71.58  ? 308 ASN C C   1 
ATOM 2597 O O   . ASN C 1 110 ? -53.503 13.935  -14.414 1.00 77.16  ? 308 ASN C O   1 
ATOM 2598 C CB  . ASN C 1 110 ? -55.421 11.899  -15.462 1.00 55.18  ? 308 ASN C CB  1 
ATOM 2599 C CG  . ASN C 1 110 ? -56.743 11.487  -16.078 1.00 71.16  ? 308 ASN C CG  1 
ATOM 2600 O OD1 . ASN C 1 110 ? -57.356 12.249  -16.826 1.00 84.26  ? 308 ASN C OD1 1 
ATOM 2601 N ND2 . ASN C 1 110 ? -57.191 10.277  -15.764 1.00 69.95  ? 308 ASN C ND2 1 
ATOM 2602 N N   . LEU C 1 111 ? -52.289 13.178  -16.151 1.00 65.49  ? 309 LEU C N   1 
ATOM 2603 C CA  . LEU C 1 111 ? -51.019 13.549  -15.549 1.00 73.47  ? 309 LEU C CA  1 
ATOM 2604 C C   . LEU C 1 111 ? -50.818 15.061  -15.634 1.00 73.99  ? 309 LEU C C   1 
ATOM 2605 O O   . LEU C 1 111 ? -51.627 15.798  -16.205 1.00 75.31  ? 309 LEU C O   1 
ATOM 2606 C CB  . LEU C 1 111 ? -49.872 12.810  -16.235 1.00 69.12  ? 309 LEU C CB  1 
ATOM 2607 C CG  . LEU C 1 111 ? -49.872 11.283  -16.135 1.00 74.24  ? 309 LEU C CG  1 
ATOM 2608 C CD1 . LEU C 1 111 ? -48.771 10.690  -17.000 1.00 66.46  ? 309 LEU C CD1 1 
ATOM 2609 C CD2 . LEU C 1 111 ? -49.717 10.842  -14.688 1.00 53.21  ? 309 LEU C CD2 1 
ATOM 2610 N N   . ASP C 1 112 ? -49.717 15.527  -15.048 1.00 79.60  ? 310 ASP C N   1 
ATOM 2611 C CA  . ASP C 1 112 ? -49.359 16.935  -15.148 1.00 80.42  ? 310 ASP C CA  1 
ATOM 2612 C C   . ASP C 1 112 ? -49.064 17.287  -16.600 1.00 78.86  ? 310 ASP C C   1 
ATOM 2613 O O   . ASP C 1 112 ? -48.326 16.574  -17.286 1.00 84.12  ? 310 ASP C O   1 
ATOM 2614 C CB  . ASP C 1 112 ? -48.148 17.233  -14.262 1.00 88.77  ? 310 ASP C CB  1 
ATOM 2615 C CG  . ASP C 1 112 ? -47.897 18.722  -14.086 1.00 100.03 ? 310 ASP C CG  1 
ATOM 2616 O OD1 . ASP C 1 112 ? -47.777 19.442  -15.101 1.00 102.34 ? 310 ASP C OD1 1 
ATOM 2617 O OD2 . ASP C 1 112 ? -47.822 19.175  -12.925 1.00 116.89 ? 310 ASP C OD2 1 
ATOM 2618 N N   . LEU C 1 113 ? -49.656 18.390  -17.069 1.00 83.21  ? 311 LEU C N   1 
ATOM 2619 C CA  . LEU C 1 113 ? -49.478 18.794  -18.461 1.00 79.43  ? 311 LEU C CA  1 
ATOM 2620 C C   . LEU C 1 113 ? -48.007 19.010  -18.790 1.00 86.73  ? 311 LEU C C   1 
ATOM 2621 O O   . LEU C 1 113 ? -47.543 18.630  -19.872 1.00 87.29  ? 311 LEU C O   1 
ATOM 2622 C CB  . LEU C 1 113 ? -50.284 20.061  -18.747 1.00 79.50  ? 311 LEU C CB  1 
ATOM 2623 C CG  . LEU C 1 113 ? -50.163 20.628  -20.163 1.00 87.87  ? 311 LEU C CG  1 
ATOM 2624 C CD1 . LEU C 1 113 ? -50.637 19.612  -21.188 1.00 83.92  ? 311 LEU C CD1 1 
ATOM 2625 C CD2 . LEU C 1 113 ? -50.940 21.929  -20.293 1.00 84.22  ? 311 LEU C CD2 1 
ATOM 2626 N N   . ASN C 1 114 ? -47.255 19.612  -17.867 1.00 79.67  ? 312 ASN C N   1 
ATOM 2627 C CA  . ASN C 1 114 ? -45.825 19.796  -18.078 1.00 83.87  ? 312 ASN C CA  1 
ATOM 2628 C C   . ASN C 1 114 ? -45.066 18.476  -18.070 1.00 80.14  ? 312 ASN C C   1 
ATOM 2629 O O   . ASN C 1 114 ? -43.983 18.395  -18.658 1.00 80.49  ? 312 ASN C O   1 
ATOM 2630 C CB  . ASN C 1 114 ? -45.257 20.740  -17.017 1.00 91.05  ? 312 ASN C CB  1 
ATOM 2631 C CG  . ASN C 1 114 ? -45.847 22.134  -17.106 1.00 103.50 ? 312 ASN C CG  1 
ATOM 2632 O OD1 . ASN C 1 114 ? -46.033 22.673  -18.198 1.00 113.30 ? 312 ASN C OD1 1 
ATOM 2633 N ND2 . ASN C 1 114 ? -46.151 22.723  -15.956 1.00 103.99 ? 312 ASN C ND2 1 
ATOM 2634 N N   . ASP C 1 115 ? -45.607 17.445  -17.417 1.00 78.46  ? 313 ASP C N   1 
ATOM 2635 C CA  . ASP C 1 115 ? -44.996 16.122  -17.488 1.00 85.96  ? 313 ASP C CA  1 
ATOM 2636 C C   . ASP C 1 115 ? -45.371 15.406  -18.779 1.00 74.98  ? 313 ASP C C   1 
ATOM 2637 O O   . ASP C 1 115 ? -44.553 14.672  -19.343 1.00 63.04  ? 313 ASP C O   1 
ATOM 2638 C CB  . ASP C 1 115 ? -45.400 15.285  -16.274 1.00 78.93  ? 313 ASP C CB  1 
ATOM 2639 C CG  . ASP C 1 115 ? -44.647 15.679  -15.019 1.00 86.95  ? 313 ASP C CG  1 
ATOM 2640 O OD1 . ASP C 1 115 ? -43.752 16.545  -15.109 1.00 84.13  ? 313 ASP C OD1 1 
ATOM 2641 O OD2 . ASP C 1 115 ? -44.949 15.120  -13.943 1.00 77.95  ? 313 ASP C OD2 1 
ATOM 2642 N N   . GLN C 1 116 ? -46.602 15.607  -19.259 1.00 68.38  ? 314 GLN C N   1 
ATOM 2643 C CA  . GLN C 1 116 ? -46.994 15.045  -20.548 1.00 71.33  ? 314 GLN C CA  1 
ATOM 2644 C C   . GLN C 1 116 ? -46.093 15.559  -21.662 1.00 69.01  ? 314 GLN C C   1 
ATOM 2645 O O   . GLN C 1 116 ? -45.638 14.785  -22.513 1.00 60.03  ? 314 GLN C O   1 
ATOM 2646 C CB  . GLN C 1 116 ? -48.455 15.381  -20.846 1.00 62.22  ? 314 GLN C CB  1 
ATOM 2647 C CG  . GLN C 1 116 ? -49.444 14.886  -19.806 1.00 67.32  ? 314 GLN C CG  1 
ATOM 2648 C CD  . GLN C 1 116 ? -50.873 15.268  -20.142 1.00 76.10  ? 314 GLN C CD  1 
ATOM 2649 O OE1 . GLN C 1 116 ? -51.176 15.649  -21.272 1.00 69.63  ? 314 GLN C OE1 1 
ATOM 2650 N NE2 . GLN C 1 116 ? -51.758 15.172  -19.158 1.00 70.31  ? 314 GLN C NE2 1 
ATOM 2651 N N   . VAL C 1 117 ? -45.823 16.865  -21.670 1.00 69.23  ? 315 VAL C N   1 
ATOM 2652 C CA  . VAL C 1 117 ? -44.923 17.432  -22.666 1.00 70.06  ? 315 VAL C CA  1 
ATOM 2653 C C   . VAL C 1 117 ? -43.496 16.955  -22.429 1.00 69.84  ? 315 VAL C C   1 
ATOM 2654 O O   . VAL C 1 117 ? -42.740 16.739  -23.384 1.00 72.31  ? 315 VAL C O   1 
ATOM 2655 C CB  . VAL C 1 117 ? -45.020 18.969  -22.654 1.00 77.55  ? 315 VAL C CB  1 
ATOM 2656 C CG1 . VAL C 1 117 ? -44.157 19.567  -23.749 1.00 76.93  ? 315 VAL C CG1 1 
ATOM 2657 C CG2 . VAL C 1 117 ? -46.465 19.408  -22.814 1.00 75.01  ? 315 VAL C CG2 1 
ATOM 2658 N N   . THR C 1 118 ? -43.103 16.776  -21.165 1.00 70.37  ? 316 THR C N   1 
ATOM 2659 C CA  . THR C 1 118 ? -41.768 16.263  -20.874 1.00 75.09  ? 316 THR C CA  1 
ATOM 2660 C C   . THR C 1 118 ? -41.613 14.827  -21.361 1.00 68.01  ? 316 THR C C   1 
ATOM 2661 O O   . THR C 1 118 ? -40.568 14.462  -21.913 1.00 58.20  ? 316 THR C O   1 
ATOM 2662 C CB  . THR C 1 118 ? -41.481 16.354  -19.374 1.00 67.12  ? 316 THR C CB  1 
ATOM 2663 O OG1 . THR C 1 118 ? -41.695 17.698  -18.925 1.00 71.13  ? 316 THR C OG1 1 
ATOM 2664 C CG2 . THR C 1 118 ? -40.042 15.953  -19.082 1.00 68.71  ? 316 THR C CG2 1 
ATOM 2665 N N   . LEU C 1 119 ? -42.645 14.001  -21.172 1.00 65.83  ? 317 LEU C N   1 
ATOM 2666 C CA  . LEU C 1 119 ? -42.600 12.632  -21.675 1.00 63.49  ? 317 LEU C CA  1 
ATOM 2667 C C   . LEU C 1 119 ? -42.569 12.604  -23.197 1.00 63.99  ? 317 LEU C C   1 
ATOM 2668 O O   . LEU C 1 119 ? -41.908 11.747  -23.795 1.00 59.40  ? 317 LEU C O   1 
ATOM 2669 C CB  . LEU C 1 119 ? -43.798 11.839  -21.154 1.00 57.68  ? 317 LEU C CB  1 
ATOM 2670 C CG  . LEU C 1 119 ? -43.855 11.559  -19.652 1.00 59.71  ? 317 LEU C CG  1 
ATOM 2671 C CD1 . LEU C 1 119 ? -45.136 10.822  -19.297 1.00 64.34  ? 317 LEU C CD1 1 
ATOM 2672 C CD2 . LEU C 1 119 ? -42.639 10.764  -19.214 1.00 49.45  ? 317 LEU C CD2 1 
ATOM 2673 N N   . LEU C 1 120 ? -43.275 13.534  -23.840 1.00 63.08  ? 318 LEU C N   1 
ATOM 2674 C CA  . LEU C 1 120 ? -43.335 13.551  -25.295 1.00 60.83  ? 318 LEU C CA  1 
ATOM 2675 C C   . LEU C 1 120 ? -42.113 14.214  -25.916 1.00 62.81  ? 318 LEU C C   1 
ATOM 2676 O O   . LEU C 1 120 ? -41.718 13.850  -27.027 1.00 60.40  ? 318 LEU C O   1 
ATOM 2677 C CB  . LEU C 1 120 ? -44.612 14.253  -25.756 1.00 56.75  ? 318 LEU C CB  1 
ATOM 2678 C CG  . LEU C 1 120 ? -45.900 13.479  -25.477 1.00 52.62  ? 318 LEU C CG  1 
ATOM 2679 C CD1 . LEU C 1 120 ? -47.109 14.386  -25.591 1.00 54.86  ? 318 LEU C CD1 1 
ATOM 2680 C CD2 . LEU C 1 120 ? -46.021 12.296  -26.424 1.00 50.70  ? 318 LEU C CD2 1 
ATOM 2681 N N   . LYS C 1 121 ? -41.500 15.178  -25.224 1.00 63.79  ? 319 LYS C N   1 
ATOM 2682 C CA  . LYS C 1 121 ? -40.315 15.832  -25.770 1.00 70.58  ? 319 LYS C CA  1 
ATOM 2683 C C   . LYS C 1 121 ? -39.135 14.871  -25.848 1.00 69.82  ? 319 LYS C C   1 
ATOM 2684 O O   . LYS C 1 121 ? -38.432 14.824  -26.864 1.00 60.35  ? 319 LYS C O   1 
ATOM 2685 C CB  . LYS C 1 121 ? -39.953 17.054  -24.926 1.00 74.84  ? 319 LYS C CB  1 
ATOM 2686 C CG  . LYS C 1 121 ? -38.588 17.644  -25.246 1.00 94.90  ? 319 LYS C CG  1 
ATOM 2687 C CD  . LYS C 1 121 ? -38.263 18.819  -24.339 1.00 92.00  ? 319 LYS C CD  1 
ATOM 2688 C CE  . LYS C 1 121 ? -36.826 19.279  -24.527 1.00 87.39  ? 319 LYS C CE  1 
ATOM 2689 N NZ  . LYS C 1 121 ? -36.540 19.658  -25.938 1.00 73.67  ? 319 LYS C NZ  1 
ATOM 2690 N N   . TYR C 1 122 ? -38.906 14.097  -24.792 1.00 65.47  ? 320 TYR C N   1 
ATOM 2691 C CA  . TYR C 1 122 ? -37.770 13.188  -24.720 1.00 71.03  ? 320 TYR C CA  1 
ATOM 2692 C C   . TYR C 1 122 ? -38.060 11.812  -25.304 1.00 73.96  ? 320 TYR C C   1 
ATOM 2693 O O   . TYR C 1 122 ? -37.150 10.977  -25.357 1.00 80.70  ? 320 TYR C O   1 
ATOM 2694 C CB  . TYR C 1 122 ? -37.310 13.035  -23.266 1.00 71.66  ? 320 TYR C CB  1 
ATOM 2695 C CG  . TYR C 1 122 ? -36.625 14.260  -22.705 1.00 75.72  ? 320 TYR C CG  1 
ATOM 2696 C CD1 . TYR C 1 122 ? -37.362 15.323  -22.201 1.00 81.47  ? 320 TYR C CD1 1 
ATOM 2697 C CD2 . TYR C 1 122 ? -35.240 14.350  -22.677 1.00 77.99  ? 320 TYR C CD2 1 
ATOM 2698 C CE1 . TYR C 1 122 ? -36.738 16.444  -21.687 1.00 85.02  ? 320 TYR C CE1 1 
ATOM 2699 C CE2 . TYR C 1 122 ? -34.607 15.465  -22.165 1.00 81.99  ? 320 TYR C CE2 1 
ATOM 2700 C CZ  . TYR C 1 122 ? -35.360 16.509  -21.671 1.00 91.97  ? 320 TYR C CZ  1 
ATOM 2701 O OH  . TYR C 1 122 ? -34.733 17.622  -21.160 1.00 101.53 ? 320 TYR C OH  1 
ATOM 2702 N N   . GLY C 1 123 ? -39.287 11.551  -25.745 1.00 63.41  ? 321 GLY C N   1 
ATOM 2703 C CA  . GLY C 1 123 ? -39.627 10.228  -26.226 1.00 59.86  ? 321 GLY C CA  1 
ATOM 2704 C C   . GLY C 1 123 ? -40.089 10.175  -27.667 1.00 62.08  ? 321 GLY C C   1 
ATOM 2705 O O   . GLY C 1 123 ? -40.175 9.089   -28.247 1.00 52.37  ? 321 GLY C O   1 
ATOM 2706 N N   . VAL C 1 124 ? -40.380 11.334  -28.264 1.00 56.50  ? 322 VAL C N   1 
ATOM 2707 C CA  . VAL C 1 124 ? -40.960 11.345  -29.604 1.00 52.79  ? 322 VAL C CA  1 
ATOM 2708 C C   . VAL C 1 124 ? -39.952 10.848  -30.634 1.00 54.44  ? 322 VAL C C   1 
ATOM 2709 O O   . VAL C 1 124 ? -40.316 10.161  -31.596 1.00 49.67  ? 322 VAL C O   1 
ATOM 2710 C CB  . VAL C 1 124 ? -41.491 12.750  -29.949 1.00 51.35  ? 322 VAL C CB  1 
ATOM 2711 C CG1 . VAL C 1 124 ? -40.361 13.777  -29.972 1.00 66.09  ? 322 VAL C CG1 1 
ATOM 2712 C CG2 . VAL C 1 124 ? -42.235 12.729  -31.269 1.00 66.50  ? 322 VAL C CG2 1 
ATOM 2713 N N   . HIS C 1 125 ? -38.669 11.166  -30.442 1.00 53.14  ? 323 HIS C N   1 
ATOM 2714 C CA  . HIS C 1 125 ? -37.652 10.724  -31.390 1.00 51.57  ? 323 HIS C CA  1 
ATOM 2715 C C   . HIS C 1 125 ? -37.402 9.226   -31.290 1.00 57.77  ? 323 HIS C C   1 
ATOM 2716 O O   . HIS C 1 125 ? -37.109 8.580   -32.303 1.00 50.95  ? 323 HIS C O   1 
ATOM 2717 C CB  . HIS C 1 125 ? -36.356 11.503  -31.171 1.00 59.75  ? 323 HIS C CB  1 
ATOM 2718 C CG  . HIS C 1 125 ? -36.412 12.915  -31.665 1.00 70.57  ? 323 HIS C CG  1 
ATOM 2719 N ND1 . HIS C 1 125 ? -37.083 13.915  -30.994 1.00 80.59  ? 323 HIS C ND1 1 
ATOM 2720 C CD2 . HIS C 1 125 ? -35.889 13.492  -32.773 1.00 75.27  ? 323 HIS C CD2 1 
ATOM 2721 C CE1 . HIS C 1 125 ? -36.967 15.048  -31.665 1.00 90.81  ? 323 HIS C CE1 1 
ATOM 2722 N NE2 . HIS C 1 125 ? -36.248 14.818  -32.748 1.00 88.43  ? 323 HIS C NE2 1 
ATOM 2723 N N   . GLU C 1 126 ? -37.507 8.659   -30.087 1.00 63.17  ? 324 GLU C N   1 
ATOM 2724 C CA  . GLU C 1 126 ? -37.392 7.212   -29.947 1.00 55.86  ? 324 GLU C CA  1 
ATOM 2725 C C   . GLU C 1 126 ? -38.562 6.495   -30.607 1.00 51.13  ? 324 GLU C C   1 
ATOM 2726 O O   . GLU C 1 126 ? -38.389 5.399   -31.153 1.00 44.25  ? 324 GLU C O   1 
ATOM 2727 C CB  . GLU C 1 126 ? -37.295 6.838   -28.468 1.00 49.38  ? 324 GLU C CB  1 
ATOM 2728 C CG  . GLU C 1 126 ? -36.150 7.525   -27.740 1.00 59.39  ? 324 GLU C CG  1 
ATOM 2729 C CD  . GLU C 1 126 ? -36.225 7.358   -26.235 1.00 60.04  ? 324 GLU C CD  1 
ATOM 2730 O OE1 . GLU C 1 126 ? -36.962 6.465   -25.767 1.00 59.56  ? 324 GLU C OE1 1 
ATOM 2731 O OE2 . GLU C 1 126 ? -35.549 8.126   -25.519 1.00 69.33  ? 324 GLU C OE2 1 
ATOM 2732 N N   . ILE C 1 127 ? -39.753 7.098   -30.575 1.00 48.20  ? 325 ILE C N   1 
ATOM 2733 C CA  . ILE C 1 127 ? -40.904 6.509   -31.250 1.00 48.59  ? 325 ILE C CA  1 
ATOM 2734 C C   . ILE C 1 127 ? -40.736 6.592   -32.762 1.00 46.86  ? 325 ILE C C   1 
ATOM 2735 O O   . ILE C 1 127 ? -41.124 5.674   -33.495 1.00 48.81  ? 325 ILE C O   1 
ATOM 2736 C CB  . ILE C 1 127 ? -42.203 7.196   -30.789 1.00 51.58  ? 325 ILE C CB  1 
ATOM 2737 C CG1 . ILE C 1 127 ? -42.361 7.087   -29.272 1.00 44.53  ? 325 ILE C CG1 1 
ATOM 2738 C CG2 . ILE C 1 127 ? -43.409 6.587   -31.486 1.00 35.22  ? 325 ILE C CG2 1 
ATOM 2739 C CD1 . ILE C 1 127 ? -42.475 5.672   -28.777 1.00 55.45  ? 325 ILE C CD1 1 
ATOM 2740 N N   . ILE C 1 128 ? -40.157 7.691   -33.253 1.00 53.02  ? 326 ILE C N   1 
ATOM 2741 C CA  . ILE C 1 128 ? -39.983 7.868   -34.693 1.00 51.89  ? 326 ILE C CA  1 
ATOM 2742 C C   . ILE C 1 128 ? -39.066 6.789   -35.255 1.00 51.47  ? 326 ILE C C   1 
ATOM 2743 O O   . ILE C 1 128 ? -39.369 6.159   -36.276 1.00 52.22  ? 326 ILE C O   1 
ATOM 2744 C CB  . ILE C 1 128 ? -39.448 9.279   -35.000 1.00 43.54  ? 326 ILE C CB  1 
ATOM 2745 C CG1 . ILE C 1 128 ? -40.530 10.329  -34.743 1.00 51.67  ? 326 ILE C CG1 1 
ATOM 2746 C CG2 . ILE C 1 128 ? -38.947 9.363   -36.434 1.00 51.79  ? 326 ILE C CG2 1 
ATOM 2747 C CD1 . ILE C 1 128 ? -40.058 11.753  -34.944 1.00 55.44  ? 326 ILE C CD1 1 
ATOM 2748 N N   . TYR C 1 129 ? -37.932 6.554   -34.591 1.00 52.27  ? 327 TYR C N   1 
ATOM 2749 C CA  . TYR C 1 129 ? -36.990 5.551   -35.076 1.00 54.87  ? 327 TYR C CA  1 
ATOM 2750 C C   . TYR C 1 129 ? -37.541 4.139   -34.930 1.00 47.87  ? 327 TYR C C   1 
ATOM 2751 O O   . TYR C 1 129 ? -37.156 3.245   -35.692 1.00 56.03  ? 327 TYR C O   1 
ATOM 2752 C CB  . TYR C 1 129 ? -35.658 5.690   -34.340 1.00 47.78  ? 327 TYR C CB  1 
ATOM 2753 C CG  . TYR C 1 129 ? -34.937 6.978   -34.661 1.00 59.81  ? 327 TYR C CG  1 
ATOM 2754 C CD1 . TYR C 1 129 ? -34.952 7.498   -35.949 1.00 61.39  ? 327 TYR C CD1 1 
ATOM 2755 C CD2 . TYR C 1 129 ? -34.255 7.681   -33.678 1.00 65.76  ? 327 TYR C CD2 1 
ATOM 2756 C CE1 . TYR C 1 129 ? -34.300 8.677   -36.251 1.00 66.82  ? 327 TYR C CE1 1 
ATOM 2757 C CE2 . TYR C 1 129 ? -33.599 8.863   -33.971 1.00 65.66  ? 327 TYR C CE2 1 
ATOM 2758 C CZ  . TYR C 1 129 ? -33.625 9.355   -35.259 1.00 80.38  ? 327 TYR C CZ  1 
ATOM 2759 O OH  . TYR C 1 129 ? -32.975 10.530  -35.558 1.00 94.84  ? 327 TYR C OH  1 
ATOM 2760 N N   . THR C 1 130 ? -38.441 3.916   -33.970 1.00 46.36  ? 328 THR C N   1 
ATOM 2761 C CA  . THR C 1 130 ? -39.063 2.603   -33.837 1.00 44.17  ? 328 THR C CA  1 
ATOM 2762 C C   . THR C 1 130 ? -40.014 2.333   -34.996 1.00 47.29  ? 328 THR C C   1 
ATOM 2763 O O   . THR C 1 130 ? -39.978 1.258   -35.606 1.00 43.25  ? 328 THR C O   1 
ATOM 2764 C CB  . THR C 1 130 ? -39.803 2.502   -32.503 1.00 50.03  ? 328 THR C CB  1 
ATOM 2765 O OG1 . THR C 1 130 ? -38.889 2.745   -31.426 1.00 53.25  ? 328 THR C OG1 1 
ATOM 2766 C CG2 . THR C 1 130 ? -40.413 1.119   -32.339 1.00 42.69  ? 328 THR C CG2 1 
ATOM 2767 N N   . MET C 1 131 ? -40.871 3.302   -35.315 1.00 50.00  ? 329 MET C N   1 
ATOM 2768 C CA  . MET C 1 131 ? -41.809 3.168   -36.420 1.00 59.26  ? 329 MET C CA  1 
ATOM 2769 C C   . MET C 1 131 ? -41.154 3.362   -37.781 1.00 44.45  ? 329 MET C C   1 
ATOM 2770 O O   . MET C 1 131 ? -41.755 2.997   -38.796 1.00 42.77  ? 329 MET C O   1 
ATOM 2771 C CB  . MET C 1 131 ? -42.961 4.161   -36.245 1.00 40.45  ? 329 MET C CB  1 
ATOM 2772 C CG  . MET C 1 131 ? -43.637 4.066   -34.884 1.00 46.45  ? 329 MET C CG  1 
ATOM 2773 S SD  . MET C 1 131 ? -45.140 5.051   -34.758 1.00 56.93  ? 329 MET C SD  1 
ATOM 2774 C CE  . MET C 1 131 ? -46.163 4.249   -35.991 1.00 54.99  ? 329 MET C CE  1 
ATOM 2775 N N   . LEU C 1 132 ? -39.943 3.925   -37.827 1.00 48.08  ? 330 LEU C N   1 
ATOM 2776 C CA  . LEU C 1 132 ? -39.226 4.028   -39.093 1.00 41.23  ? 330 LEU C CA  1 
ATOM 2777 C C   . LEU C 1 132 ? -38.724 2.668   -39.561 1.00 52.17  ? 330 LEU C C   1 
ATOM 2778 O O   . LEU C 1 132 ? -38.602 2.435   -40.769 1.00 56.15  ? 330 LEU C O   1 
ATOM 2779 C CB  . LEU C 1 132 ? -38.062 5.011   -38.959 1.00 50.18  ? 330 LEU C CB  1 
ATOM 2780 C CG  . LEU C 1 132 ? -37.229 5.290   -40.212 1.00 53.93  ? 330 LEU C CG  1 
ATOM 2781 C CD1 . LEU C 1 132 ? -38.098 5.857   -41.324 1.00 40.19  ? 330 LEU C CD1 1 
ATOM 2782 C CD2 . LEU C 1 132 ? -36.078 6.233   -39.893 1.00 53.41  ? 330 LEU C CD2 1 
ATOM 2783 N N   . ALA C 1 133 ? -38.434 1.761   -38.624 1.00 48.07  ? 331 ALA C N   1 
ATOM 2784 C CA  . ALA C 1 133 ? -38.001 0.419   -38.997 1.00 46.62  ? 331 ALA C CA  1 
ATOM 2785 C C   . ALA C 1 133 ? -39.098 -0.341  -39.732 1.00 47.35  ? 331 ALA C C   1 
ATOM 2786 O O   . ALA C 1 133 ? -38.801 -1.255  -40.509 1.00 51.34  ? 331 ALA C O   1 
ATOM 2787 C CB  . ALA C 1 133 ? -37.558 -0.357  -37.756 1.00 43.17  ? 331 ALA C CB  1 
ATOM 2788 N N   . SER C 1 134 ? -40.363 0.019   -39.501 1.00 45.57  ? 332 SER C N   1 
ATOM 2789 C CA  . SER C 1 134 ? -41.458 -0.618  -40.223 1.00 47.68  ? 332 SER C CA  1 
ATOM 2790 C C   . SER C 1 134 ? -41.408 -0.298  -41.711 1.00 46.13  ? 332 SER C C   1 
ATOM 2791 O O   . SER C 1 134 ? -41.916 -1.071  -42.531 1.00 49.89  ? 332 SER C O   1 
ATOM 2792 C CB  . SER C 1 134 ? -42.800 -0.183  -39.634 1.00 44.21  ? 332 SER C CB  1 
ATOM 2793 O OG  . SER C 1 134 ? -42.916 -0.579  -38.279 1.00 48.31  ? 332 SER C OG  1 
ATOM 2794 N N   . LEU C 1 135 ? -40.802 0.829   -42.077 1.00 39.71  ? 333 LEU C N   1 
ATOM 2795 C CA  . LEU C 1 135 ? -40.672 1.237   -43.468 1.00 56.63  ? 333 LEU C CA  1 
ATOM 2796 C C   . LEU C 1 135 ? -39.359 0.785   -44.093 1.00 54.24  ? 333 LEU C C   1 
ATOM 2797 O O   . LEU C 1 135 ? -39.073 1.156   -45.235 1.00 59.60  ? 333 LEU C O   1 
ATOM 2798 C CB  . LEU C 1 135 ? -40.794 2.760   -43.585 1.00 42.93  ? 333 LEU C CB  1 
ATOM 2799 C CG  . LEU C 1 135 ? -41.918 3.445   -42.806 1.00 56.16  ? 333 LEU C CG  1 
ATOM 2800 C CD1 . LEU C 1 135 ? -41.908 4.943   -43.067 1.00 49.69  ? 333 LEU C CD1 1 
ATOM 2801 C CD2 . LEU C 1 135 ? -43.265 2.848   -43.162 1.00 50.79  ? 333 LEU C CD2 1 
ATOM 2802 N N   . MET C 1 136 ? -38.561 -0.006  -43.380 1.00 46.64  ? 334 MET C N   1 
ATOM 2803 C CA  . MET C 1 136 ? -37.213 -0.345  -43.807 1.00 46.88  ? 334 MET C CA  1 
ATOM 2804 C C   . MET C 1 136 ? -37.051 -1.847  -43.990 1.00 51.29  ? 334 MET C C   1 
ATOM 2805 O O   . MET C 1 136 ? -37.733 -2.650  -43.346 1.00 54.87  ? 334 MET C O   1 
ATOM 2806 C CB  . MET C 1 136 ? -36.164 0.145   -42.797 1.00 42.36  ? 334 MET C CB  1 
ATOM 2807 C CG  . MET C 1 136 ? -35.952 1.646   -42.776 1.00 59.97  ? 334 MET C CG  1 
ATOM 2808 S SD  . MET C 1 136 ? -34.705 2.145   -41.572 1.00 54.04  ? 334 MET C SD  1 
ATOM 2809 C CE  . MET C 1 136 ? -34.365 3.817   -42.110 1.00 65.35  ? 334 MET C CE  1 
ATOM 2810 N N   . ASN C 1 137 ? -36.142 -2.209  -44.884 1.00 57.01  ? 335 ASN C N   1 
ATOM 2811 C CA  . ASN C 1 137 ? -35.578 -3.554  -44.945 1.00 47.70  ? 335 ASN C CA  1 
ATOM 2812 C C   . ASN C 1 137 ? -34.070 -3.396  -45.099 1.00 51.68  ? 335 ASN C C   1 
ATOM 2813 O O   . ASN C 1 137 ? -33.514 -2.316  -44.870 1.00 59.18  ? 335 ASN C O   1 
ATOM 2814 C CB  . ASN C 1 137 ? -36.225 -4.384  -46.065 1.00 54.03  ? 335 ASN C CB  1 
ATOM 2815 C CG  . ASN C 1 137 ? -36.148 -3.710  -47.426 1.00 65.20  ? 335 ASN C CG  1 
ATOM 2816 O OD1 . ASN C 1 137 ? -35.349 -2.798  -47.648 1.00 66.78  ? 335 ASN C OD1 1 
ATOM 2817 N ND2 . ASN C 1 137 ? -36.987 -4.165  -48.350 1.00 44.35  ? 335 ASN C ND2 1 
ATOM 2818 N N   . LYS C 1 138 ? -33.388 -4.466  -45.505 1.00 63.40  ? 336 LYS C N   1 
ATOM 2819 C CA  . LYS C 1 138 ? -31.940 -4.395  -45.663 1.00 75.80  ? 336 LYS C CA  1 
ATOM 2820 C C   . LYS C 1 138 ? -31.517 -3.617  -46.903 1.00 70.92  ? 336 LYS C C   1 
ATOM 2821 O O   . LYS C 1 138 ? -30.319 -3.369  -47.073 1.00 78.29  ? 336 LYS C O   1 
ATOM 2822 C CB  . LYS C 1 138 ? -31.339 -5.805  -45.714 1.00 68.00  ? 336 LYS C CB  1 
ATOM 2823 C CG  . LYS C 1 138 ? -31.640 -6.568  -46.991 1.00 70.57  ? 336 LYS C CG  1 
ATOM 2824 C CD  . LYS C 1 138 ? -31.028 -7.957  -46.954 1.00 78.91  ? 336 LYS C CD  1 
ATOM 2825 C CE  . LYS C 1 138 ? -31.178 -8.661  -48.291 1.00 89.92  ? 336 LYS C CE  1 
ATOM 2826 N NZ  . LYS C 1 138 ? -30.429 -7.955  -49.368 1.00 91.71  ? 336 LYS C NZ  1 
ATOM 2827 N N   . ASP C 1 139 ? -32.459 -3.219  -47.759 1.00 77.68  ? 337 ASP C N   1 
ATOM 2828 C CA  . ASP C 1 139 ? -32.136 -2.566  -49.021 1.00 71.45  ? 337 ASP C CA  1 
ATOM 2829 C C   . ASP C 1 139 ? -32.476 -1.084  -49.064 1.00 75.28  ? 337 ASP C C   1 
ATOM 2830 O O   . ASP C 1 139 ? -31.792 -0.335  -49.765 1.00 70.60  ? 337 ASP C O   1 
ATOM 2831 C CB  . ASP C 1 139 ? -32.853 -3.267  -50.184 1.00 79.52  ? 337 ASP C CB  1 
ATOM 2832 C CG  . ASP C 1 139 ? -32.406 -4.704  -50.361 1.00 80.73  ? 337 ASP C CG  1 
ATOM 2833 O OD1 . ASP C 1 139 ? -31.236 -5.005  -50.040 1.00 86.17  ? 337 ASP C OD1 1 
ATOM 2834 O OD2 . ASP C 1 139 ? -33.222 -5.532  -50.815 1.00 70.57  ? 337 ASP C OD2 1 
ATOM 2835 N N   . GLY C 1 140 ? -33.499 -0.638  -48.347 1.00 71.53  ? 338 GLY C N   1 
ATOM 2836 C CA  . GLY C 1 140 ? -33.859 0.765   -48.393 1.00 67.10  ? 338 GLY C CA  1 
ATOM 2837 C C   . GLY C 1 140 ? -34.990 1.083   -47.442 1.00 67.09  ? 338 GLY C C   1 
ATOM 2838 O O   . GLY C 1 140 ? -35.316 0.296   -46.550 1.00 62.37  ? 338 GLY C O   1 
ATOM 2839 N N   . VAL C 1 141 ? -35.592 2.253   -47.650 1.00 64.99  ? 339 VAL C N   1 
ATOM 2840 C CA  . VAL C 1 141 ? -36.640 2.772   -46.779 1.00 52.45  ? 339 VAL C CA  1 
ATOM 2841 C C   . VAL C 1 141 ? -37.731 3.399   -47.638 1.00 65.58  ? 339 VAL C C   1 
ATOM 2842 O O   . VAL C 1 141 ? -37.444 4.069   -48.636 1.00 59.20  ? 339 VAL C O   1 
ATOM 2843 C CB  . VAL C 1 141 ? -36.074 3.791   -45.765 1.00 57.09  ? 339 VAL C CB  1 
ATOM 2844 C CG1 . VAL C 1 141 ? -35.281 4.877   -46.479 1.00 52.93  ? 339 VAL C CG1 1 
ATOM 2845 C CG2 . VAL C 1 141 ? -37.188 4.400   -44.922 1.00 56.31  ? 339 VAL C CG2 1 
ATOM 2846 N N   . LEU C 1 142 ? -38.985 3.170   -47.255 1.00 63.37  ? 340 LEU C N   1 
ATOM 2847 C CA  . LEU C 1 142 ? -40.107 3.784   -47.951 1.00 54.52  ? 340 LEU C CA  1 
ATOM 2848 C C   . LEU C 1 142 ? -40.197 5.268   -47.618 1.00 60.53  ? 340 LEU C C   1 
ATOM 2849 O O   . LEU C 1 142 ? -39.981 5.680   -46.474 1.00 52.24  ? 340 LEU C O   1 
ATOM 2850 C CB  . LEU C 1 142 ? -41.416 3.090   -47.575 1.00 44.87  ? 340 LEU C CB  1 
ATOM 2851 C CG  . LEU C 1 142 ? -41.652 1.685   -48.129 1.00 59.68  ? 340 LEU C CG  1 
ATOM 2852 C CD1 . LEU C 1 142 ? -42.906 1.077   -47.521 1.00 48.53  ? 340 LEU C CD1 1 
ATOM 2853 C CD2 . LEU C 1 142 ? -41.748 1.719   -49.647 1.00 52.81  ? 340 LEU C CD2 1 
ATOM 2854 N N   . ILE C 1 143 ? -40.519 6.075   -48.630 1.00 57.92  ? 341 ILE C N   1 
ATOM 2855 C CA  . ILE C 1 143 ? -40.702 7.509   -48.464 1.00 58.55  ? 341 ILE C CA  1 
ATOM 2856 C C   . ILE C 1 143 ? -42.015 7.913   -49.121 1.00 65.51  ? 341 ILE C C   1 
ATOM 2857 O O   . ILE C 1 143 ? -42.585 7.177   -49.931 1.00 59.25  ? 341 ILE C O   1 
ATOM 2858 C CB  . ILE C 1 143 ? -39.534 8.329   -49.057 1.00 66.22  ? 341 ILE C CB  1 
ATOM 2859 C CG1 . ILE C 1 143 ? -39.449 8.121   -50.570 1.00 67.17  ? 341 ILE C CG1 1 
ATOM 2860 C CG2 . ILE C 1 143 ? -38.221 7.964   -48.381 1.00 55.31  ? 341 ILE C CG2 1 
ATOM 2861 C CD1 . ILE C 1 143 ? -38.445 9.020   -51.254 1.00 65.97  ? 341 ILE C CD1 1 
ATOM 2862 N N   . SER C 1 144 ? -42.490 9.106   -48.755 1.00 55.60  ? 342 SER C N   1 
ATOM 2863 C CA  . SER C 1 144 ? -43.719 9.681   -49.307 1.00 56.78  ? 342 SER C CA  1 
ATOM 2864 C C   . SER C 1 144 ? -44.915 8.755   -49.096 1.00 58.19  ? 342 SER C C   1 
ATOM 2865 O O   . SER C 1 144 ? -45.749 8.578   -49.987 1.00 58.79  ? 342 SER C O   1 
ATOM 2866 C CB  . SER C 1 144 ? -43.552 10.027  -50.788 1.00 52.70  ? 342 SER C CB  1 
ATOM 2867 O OG  . SER C 1 144 ? -42.546 11.007  -50.971 1.00 67.85  ? 342 SER C OG  1 
ATOM 2868 N N   . GLU C 1 145 ? -44.996 8.163   -47.904 1.00 59.85  ? 343 GLU C N   1 
ATOM 2869 C CA  . GLU C 1 145 ? -46.081 7.253   -47.533 1.00 63.36  ? 343 GLU C CA  1 
ATOM 2870 C C   . GLU C 1 145 ? -46.223 6.116   -48.543 1.00 58.62  ? 343 GLU C C   1 
ATOM 2871 O O   . GLU C 1 145 ? -47.304 5.847   -49.071 1.00 64.00  ? 343 GLU C O   1 
ATOM 2872 C CB  . GLU C 1 145 ? -47.402 8.008   -47.367 1.00 77.93  ? 343 GLU C CB  1 
ATOM 2873 C CG  . GLU C 1 145 ? -47.452 8.914   -46.146 1.00 92.07  ? 343 GLU C CG  1 
ATOM 2874 C CD  . GLU C 1 145 ? -48.851 9.424   -45.856 1.00 109.41 ? 343 GLU C CD  1 
ATOM 2875 O OE1 . GLU C 1 145 ? -49.772 9.115   -46.641 1.00 124.80 ? 343 GLU C OE1 1 
ATOM 2876 O OE2 . GLU C 1 145 ? -49.030 10.132  -44.843 1.00 95.14  ? 343 GLU C OE2 1 
ATOM 2877 N N   . GLY C 1 146 ? -45.107 5.442   -48.811 1.00 62.08  ? 344 GLY C N   1 
ATOM 2878 C CA  . GLY C 1 146 ? -45.096 4.303   -49.703 1.00 67.74  ? 344 GLY C CA  1 
ATOM 2879 C C   . GLY C 1 146 ? -45.017 4.626   -51.178 1.00 58.07  ? 344 GLY C C   1 
ATOM 2880 O O   . GLY C 1 146 ? -44.989 3.697   -51.995 1.00 65.41  ? 344 GLY C O   1 
ATOM 2881 N N   . GLN C 1 147 ? -44.980 5.907   -51.552 1.00 62.95  ? 345 GLN C N   1 
ATOM 2882 C CA  . GLN C 1 147 ? -44.894 6.264   -52.964 1.00 61.21  ? 345 GLN C CA  1 
ATOM 2883 C C   . GLN C 1 147 ? -43.488 6.076   -53.519 1.00 55.74  ? 345 GLN C C   1 
ATOM 2884 O O   . GLN C 1 147 ? -43.332 5.766   -54.706 1.00 54.93  ? 345 GLN C O   1 
ATOM 2885 C CB  . GLN C 1 147 ? -45.346 7.711   -53.171 1.00 62.09  ? 345 GLN C CB  1 
ATOM 2886 C CG  . GLN C 1 147 ? -46.834 7.935   -52.959 1.00 74.59  ? 345 GLN C CG  1 
ATOM 2887 C CD  . GLN C 1 147 ? -47.211 9.403   -53.001 1.00 82.20  ? 345 GLN C CD  1 
ATOM 2888 O OE1 . GLN C 1 147 ? -46.360 10.279  -52.840 1.00 63.14  ? 345 GLN C OE1 1 
ATOM 2889 N NE2 . GLN C 1 147 ? -48.491 9.679   -53.221 1.00 95.40  ? 345 GLN C NE2 1 
ATOM 2890 N N   . GLY C 1 148 ? -42.460 6.256   -52.688 1.00 55.68  ? 346 GLY C N   1 
ATOM 2891 C CA  . GLY C 1 148 ? -41.097 6.113   -53.136 1.00 57.54  ? 346 GLY C CA  1 
ATOM 2892 C C   . GLY C 1 148 ? -40.323 5.148   -52.245 1.00 60.35  ? 346 GLY C C   1 
ATOM 2893 O O   . GLY C 1 148 ? -40.718 4.857   -51.119 1.00 66.03  ? 346 GLY C O   1 
ATOM 2894 N N   . PHE C 1 149 ? -39.209 4.670   -52.789 1.00 58.86  ? 347 PHE C N   1 
ATOM 2895 C CA  . PHE C 1 149 ? -38.340 3.723   -52.087 1.00 56.88  ? 347 PHE C CA  1 
ATOM 2896 C C   . PHE C 1 149 ? -36.897 4.160   -52.315 1.00 56.16  ? 347 PHE C C   1 
ATOM 2897 O O   . PHE C 1 149 ? -36.343 3.941   -53.394 1.00 60.58  ? 347 PHE C O   1 
ATOM 2898 C CB  . PHE C 1 149 ? -38.574 2.296   -52.572 1.00 64.31  ? 347 PHE C CB  1 
ATOM 2899 C CG  . PHE C 1 149 ? -37.692 1.275   -51.910 1.00 62.87  ? 347 PHE C CG  1 
ATOM 2900 C CD1 . PHE C 1 149 ? -38.015 0.767   -50.663 1.00 62.65  ? 347 PHE C CD1 1 
ATOM 2901 C CD2 . PHE C 1 149 ? -36.546 0.816   -52.539 1.00 64.73  ? 347 PHE C CD2 1 
ATOM 2902 C CE1 . PHE C 1 149 ? -37.207 -0.174  -50.053 1.00 66.05  ? 347 PHE C CE1 1 
ATOM 2903 C CE2 . PHE C 1 149 ? -35.735 -0.124  -51.934 1.00 68.41  ? 347 PHE C CE2 1 
ATOM 2904 C CZ  . PHE C 1 149 ? -36.067 -0.621  -50.690 1.00 72.36  ? 347 PHE C CZ  1 
ATOM 2905 N N   . MET C 1 150 ? -36.297 4.773   -51.299 1.00 50.48  ? 348 MET C N   1 
ATOM 2906 C CA  . MET C 1 150 ? -34.924 5.251   -51.382 1.00 46.97  ? 348 MET C CA  1 
ATOM 2907 C C   . MET C 1 150 ? -33.988 4.165   -50.865 1.00 65.54  ? 348 MET C C   1 
ATOM 2908 O O   . MET C 1 150 ? -34.097 3.744   -49.708 1.00 64.70  ? 348 MET C O   1 
ATOM 2909 C CB  . MET C 1 150 ? -34.756 6.542   -50.583 1.00 50.53  ? 348 MET C CB  1 
ATOM 2910 C CG  . MET C 1 150 ? -33.446 7.261   -50.829 1.00 61.67  ? 348 MET C CG  1 
ATOM 2911 S SD  . MET C 1 150 ? -33.500 8.968   -50.256 1.00 77.39  ? 348 MET C SD  1 
ATOM 2912 C CE  . MET C 1 150 ? -34.793 9.633   -51.300 1.00 69.96  ? 348 MET C CE  1 
ATOM 2913 N N   . THR C 1 151 ? -33.073 3.717   -51.721 1.00 64.66  ? 349 THR C N   1 
ATOM 2914 C CA  . THR C 1 151 ? -32.204 2.602   -51.384 1.00 58.73  ? 349 THR C CA  1 
ATOM 2915 C C   . THR C 1 151 ? -31.212 2.993   -50.288 1.00 70.44  ? 349 THR C C   1 
ATOM 2916 O O   . THR C 1 151 ? -30.983 4.171   -49.996 1.00 58.29  ? 349 THR C O   1 
ATOM 2917 C CB  . THR C 1 151 ? -31.450 2.114   -52.620 1.00 54.32  ? 349 THR C CB  1 
ATOM 2918 O OG1 . THR C 1 151 ? -30.625 3.170   -53.126 1.00 70.28  ? 349 THR C OG1 1 
ATOM 2919 C CG2 . THR C 1 151 ? -32.428 1.679   -53.704 1.00 57.65  ? 349 THR C CG2 1 
ATOM 2920 N N   . ARG C 1 152 ? -30.621 1.965   -49.678 1.00 68.85  ? 350 ARG C N   1 
ATOM 2921 C CA  . ARG C 1 152 ? -29.632 2.160   -48.625 1.00 72.66  ? 350 ARG C CA  1 
ATOM 2922 C C   . ARG C 1 152 ? -28.306 2.669   -49.173 1.00 75.21  ? 350 ARG C C   1 
ATOM 2923 O O   . ARG C 1 152 ? -27.613 3.433   -48.492 1.00 70.18  ? 350 ARG C O   1 
ATOM 2924 C CB  . ARG C 1 152 ? -29.420 0.847   -47.866 1.00 75.30  ? 350 ARG C CB  1 
ATOM 2925 C CG  . ARG C 1 152 ? -28.541 0.955   -46.634 1.00 75.51  ? 350 ARG C CG  1 
ATOM 2926 C CD  . ARG C 1 152 ? -28.510 -0.377  -45.898 1.00 68.45  ? 350 ARG C CD  1 
ATOM 2927 N NE  . ARG C 1 152 ? -27.648 -0.345  -44.721 1.00 72.19  ? 350 ARG C NE  1 
ATOM 2928 C CZ  . ARG C 1 152 ? -27.494 -1.363  -43.883 1.00 76.79  ? 350 ARG C CZ  1 
ATOM 2929 N NH1 . ARG C 1 152 ? -28.150 -2.497  -44.092 1.00 65.19  ? 350 ARG C NH1 1 
ATOM 2930 N NH2 . ARG C 1 152 ? -26.688 -1.249  -42.836 1.00 74.18  ? 350 ARG C NH2 1 
ATOM 2931 N N   . GLU C 1 153 ? -27.933 2.255   -50.387 1.00 79.15  ? 351 GLU C N   1 
ATOM 2932 C CA  . GLU C 1 153 ? -26.674 2.711   -50.971 1.00 84.04  ? 351 GLU C CA  1 
ATOM 2933 C C   . GLU C 1 153 ? -26.730 4.192   -51.328 1.00 77.72  ? 351 GLU C C   1 
ATOM 2934 O O   . GLU C 1 153 ? -25.757 4.924   -51.114 1.00 74.89  ? 351 GLU C O   1 
ATOM 2935 C CB  . GLU C 1 153 ? -26.339 1.875   -52.206 1.00 89.08  ? 351 GLU C CB  1 
ATOM 2936 C CG  . GLU C 1 153 ? -26.167 0.387   -51.936 1.00 98.98  ? 351 GLU C CG  1 
ATOM 2937 C CD  . GLU C 1 153 ? -24.874 0.063   -51.210 1.00 117.19 ? 351 GLU C CD  1 
ATOM 2938 O OE1 . GLU C 1 153 ? -23.980 0.934   -51.153 1.00 116.53 ? 351 GLU C OE1 1 
ATOM 2939 O OE2 . GLU C 1 153 ? -24.753 -1.069  -50.696 1.00 114.38 ? 351 GLU C OE2 1 
ATOM 2940 N N   . PHE C 1 154 ? -27.858 4.648   -51.879 1.00 72.76  ? 352 PHE C N   1 
ATOM 2941 C CA  . PHE C 1 154 ? -27.979 6.049   -52.269 1.00 77.90  ? 352 PHE C CA  1 
ATOM 2942 C C   . PHE C 1 154 ? -27.927 6.970   -51.057 1.00 72.29  ? 352 PHE C C   1 
ATOM 2943 O O   . PHE C 1 154 ? -27.283 8.025   -51.101 1.00 80.92  ? 352 PHE C O   1 
ATOM 2944 C CB  . PHE C 1 154 ? -29.272 6.264   -53.054 1.00 75.59  ? 352 PHE C CB  1 
ATOM 2945 C CG  . PHE C 1 154 ? -29.556 7.703   -53.371 1.00 83.15  ? 352 PHE C CG  1 
ATOM 2946 C CD1 . PHE C 1 154 ? -28.853 8.356   -54.368 1.00 83.61  ? 352 PHE C CD1 1 
ATOM 2947 C CD2 . PHE C 1 154 ? -30.526 8.402   -52.673 1.00 84.15  ? 352 PHE C CD2 1 
ATOM 2948 C CE1 . PHE C 1 154 ? -29.110 9.679   -54.662 1.00 84.37  ? 352 PHE C CE1 1 
ATOM 2949 C CE2 . PHE C 1 154 ? -30.788 9.726   -52.962 1.00 84.53  ? 352 PHE C CE2 1 
ATOM 2950 C CZ  . PHE C 1 154 ? -30.078 10.365  -53.959 1.00 82.60  ? 352 PHE C CZ  1 
ATOM 2951 N N   . LEU C 1 155 ? -28.601 6.593   -49.967 1.00 80.13  ? 353 LEU C N   1 
ATOM 2952 C CA  . LEU C 1 155 ? -28.527 7.386   -48.745 1.00 81.22  ? 353 LEU C CA  1 
ATOM 2953 C C   . LEU C 1 155 ? -27.122 7.382   -48.160 1.00 79.49  ? 353 LEU C C   1 
ATOM 2954 O O   . LEU C 1 155 ? -26.695 8.374   -47.558 1.00 83.71  ? 353 LEU C O   1 
ATOM 2955 C CB  . LEU C 1 155 ? -29.531 6.863   -47.718 1.00 66.47  ? 353 LEU C CB  1 
ATOM 2956 C CG  . LEU C 1 155 ? -30.986 7.290   -47.905 1.00 66.15  ? 353 LEU C CG  1 
ATOM 2957 C CD1 . LEU C 1 155 ? -31.899 6.483   -46.998 1.00 67.03  ? 353 LEU C CD1 1 
ATOM 2958 C CD2 . LEU C 1 155 ? -31.130 8.776   -47.624 1.00 75.66  ? 353 LEU C CD2 1 
ATOM 2959 N N   . LYS C 1 156 ? -26.389 6.281   -48.330 1.00 75.97  ? 354 LYS C N   1 
ATOM 2960 C CA  . LYS C 1 156 ? -25.036 6.190   -47.796 1.00 82.83  ? 354 LYS C CA  1 
ATOM 2961 C C   . LYS C 1 156 ? -24.020 6.881   -48.697 1.00 91.52  ? 354 LYS C C   1 
ATOM 2962 O O   . LYS C 1 156 ? -22.989 7.359   -48.208 1.00 94.07  ? 354 LYS C O   1 
ATOM 2963 C CB  . LYS C 1 156 ? -24.662 4.721   -47.592 1.00 85.22  ? 354 LYS C CB  1 
ATOM 2964 C CG  . LYS C 1 156 ? -23.333 4.489   -46.893 1.00 96.37  ? 354 LYS C CG  1 
ATOM 2965 C CD  . LYS C 1 156 ? -23.170 3.026   -46.512 1.00 83.15  ? 354 LYS C CD  1 
ATOM 2966 C CE  . LYS C 1 156 ? -23.369 2.116   -47.714 1.00 95.15  ? 354 LYS C CE  1 
ATOM 2967 N NZ  . LYS C 1 156 ? -23.311 0.677   -47.337 1.00 91.01  ? 354 LYS C NZ  1 
ATOM 2968 N N   . SER C 1 157 ? -24.292 6.959   -49.999 1.00 85.41  ? 355 SER C N   1 
ATOM 2969 C CA  . SER C 1 157 ? -23.374 7.580   -50.945 1.00 84.73  ? 355 SER C CA  1 
ATOM 2970 C C   . SER C 1 157 ? -23.418 9.103   -50.912 1.00 88.72  ? 355 SER C C   1 
ATOM 2971 O O   . SER C 1 157 ? -22.645 9.740   -51.636 1.00 91.47  ? 355 SER C O   1 
ATOM 2972 C CB  . SER C 1 157 ? -23.669 7.092   -52.365 1.00 83.81  ? 355 SER C CB  1 
ATOM 2973 O OG  . SER C 1 157 ? -24.963 7.490   -52.783 1.00 81.90  ? 355 SER C OG  1 
ATOM 2974 N N   . LEU C 1 158 ? -24.298 9.698   -50.108 1.00 86.32  ? 356 LEU C N   1 
ATOM 2975 C CA  . LEU C 1 158 ? -24.339 11.149  -49.995 1.00 87.47  ? 356 LEU C CA  1 
ATOM 2976 C C   . LEU C 1 158 ? -23.039 11.670  -49.394 1.00 95.09  ? 356 LEU C C   1 
ATOM 2977 O O   . LEU C 1 158 ? -22.333 10.961  -48.672 1.00 91.38  ? 356 LEU C O   1 
ATOM 2978 C CB  . LEU C 1 158 ? -25.527 11.585  -49.137 1.00 91.26  ? 356 LEU C CB  1 
ATOM 2979 C CG  . LEU C 1 158 ? -26.922 11.257  -49.672 1.00 86.09  ? 356 LEU C CG  1 
ATOM 2980 C CD1 . LEU C 1 158 ? -27.992 11.709  -48.690 1.00 89.58  ? 356 LEU C CD1 1 
ATOM 2981 C CD2 . LEU C 1 158 ? -27.137 11.898  -51.034 1.00 85.50  ? 356 LEU C CD2 1 
ATOM 2982 N N   . ARG C 1 159 ? -22.720 12.925  -49.706 1.00 94.08  ? 357 ARG C N   1 
ATOM 2983 C CA  . ARG C 1 159 ? -21.480 13.512  -49.218 1.00 90.46  ? 357 ARG C CA  1 
ATOM 2984 C C   . ARG C 1 159 ? -21.512 13.633  -47.700 1.00 99.54  ? 357 ARG C C   1 
ATOM 2985 O O   . ARG C 1 159 ? -22.532 13.997  -47.107 1.00 99.93  ? 357 ARG C O   1 
ATOM 2986 C CB  . ARG C 1 159 ? -21.243 14.879  -49.868 1.00 96.15  ? 357 ARG C CB  1 
ATOM 2987 C CG  . ARG C 1 159 ? -22.300 15.935  -49.576 1.00 94.19  ? 357 ARG C CG  1 
ATOM 2988 C CD  . ARG C 1 159 ? -21.811 16.928  -48.531 1.00 97.79  ? 357 ARG C CD  1 
ATOM 2989 N NE  . ARG C 1 159 ? -22.706 18.073  -48.398 1.00 103.70 ? 357 ARG C NE  1 
ATOM 2990 C CZ  . ARG C 1 159 ? -22.495 19.094  -47.574 1.00 103.81 ? 357 ARG C CZ  1 
ATOM 2991 N NH1 . ARG C 1 159 ? -21.415 19.114  -46.803 1.00 109.26 ? 357 ARG C NH1 1 
ATOM 2992 N NH2 . ARG C 1 159 ? -23.363 20.094  -47.519 1.00 105.44 ? 357 ARG C NH2 1 
ATOM 2993 N N   . LYS C 1 160 ? -20.389 13.302  -47.070 1.00 101.15 ? 358 LYS C N   1 
ATOM 2994 C CA  . LYS C 1 160 ? -20.312 13.324  -45.621 1.00 99.89  ? 358 LYS C CA  1 
ATOM 2995 C C   . LYS C 1 160 ? -20.438 14.756  -45.097 1.00 98.62  ? 358 LYS C C   1 
ATOM 2996 O O   . LYS C 1 160 ? -20.073 15.712  -45.787 1.00 98.36  ? 358 LYS C O   1 
ATOM 2997 C CB  . LYS C 1 160 ? -18.998 12.703  -45.151 1.00 104.26 ? 358 LYS C CB  1 
ATOM 2998 C CG  . LYS C 1 160 ? -19.033 11.184  -45.084 1.00 108.08 ? 358 LYS C CG  1 
ATOM 2999 C CD  . LYS C 1 160 ? -17.767 10.626  -44.459 1.00 108.58 ? 358 LYS C CD  1 
ATOM 3000 C CE  . LYS C 1 160 ? -17.907 9.139   -44.180 1.00 99.64  ? 358 LYS C CE  1 
ATOM 3001 N NZ  . LYS C 1 160 ? -18.289 8.378   -45.402 1.00 112.44 ? 358 LYS C NZ  1 
ATOM 3002 N N   . PRO C 1 161 ? -20.958 14.932  -43.870 1.00 101.93 ? 359 PRO C N   1 
ATOM 3003 C CA  . PRO C 1 161 ? -21.429 13.860  -42.985 1.00 102.16 ? 359 PRO C CA  1 
ATOM 3004 C C   . PRO C 1 161 ? -22.905 13.503  -43.166 1.00 101.87 ? 359 PRO C C   1 
ATOM 3005 O O   . PRO C 1 161 ? -23.506 12.933  -42.255 1.00 102.71 ? 359 PRO C O   1 
ATOM 3006 C CB  . PRO C 1 161 ? -21.185 14.441  -41.593 1.00 107.55 ? 359 PRO C CB  1 
ATOM 3007 C CG  . PRO C 1 161 ? -21.412 15.901  -41.782 1.00 108.08 ? 359 PRO C CG  1 
ATOM 3008 C CD  . PRO C 1 161 ? -20.936 16.235  -43.179 1.00 108.70 ? 359 PRO C CD  1 
ATOM 3009 N N   . PHE C 1 162 ? -23.479 13.834  -44.325 1.00 105.43 ? 360 PHE C N   1 
ATOM 3010 C CA  . PHE C 1 162 ? -24.861 13.459  -44.605 1.00 97.42  ? 360 PHE C CA  1 
ATOM 3011 C C   . PHE C 1 162 ? -25.005 11.990  -44.981 1.00 90.57  ? 360 PHE C C   1 
ATOM 3012 O O   . PHE C 1 162 ? -26.115 11.451  -44.904 1.00 91.74  ? 360 PHE C O   1 
ATOM 3013 C CB  . PHE C 1 162 ? -25.436 14.326  -45.727 1.00 92.68  ? 360 PHE C CB  1 
ATOM 3014 C CG  . PHE C 1 162 ? -25.615 15.768  -45.352 1.00 89.75  ? 360 PHE C CG  1 
ATOM 3015 C CD1 . PHE C 1 162 ? -26.788 16.203  -44.756 1.00 86.57  ? 360 PHE C CD1 1 
ATOM 3016 C CD2 . PHE C 1 162 ? -24.616 16.692  -45.605 1.00 97.49  ? 360 PHE C CD2 1 
ATOM 3017 C CE1 . PHE C 1 162 ? -26.957 17.531  -44.414 1.00 86.42  ? 360 PHE C CE1 1 
ATOM 3018 C CE2 . PHE C 1 162 ? -24.780 18.021  -45.266 1.00 102.61 ? 360 PHE C CE2 1 
ATOM 3019 C CZ  . PHE C 1 162 ? -25.952 18.441  -44.670 1.00 97.01  ? 360 PHE C CZ  1 
ATOM 3020 N N   . GLY C 1 163 ? -23.917 11.335  -45.385 1.00 90.62  ? 361 GLY C N   1 
ATOM 3021 C CA  . GLY C 1 163 ? -23.981 9.947   -45.802 1.00 88.04  ? 361 GLY C CA  1 
ATOM 3022 C C   . GLY C 1 163 ? -24.028 8.935   -44.681 1.00 95.13  ? 361 GLY C C   1 
ATOM 3023 O O   . GLY C 1 163 ? -24.334 7.766   -44.935 1.00 94.48  ? 361 GLY C O   1 
ATOM 3024 N N   . ASP C 1 164 ? -23.733 9.352   -43.449 1.00 97.35  ? 362 ASP C N   1 
ATOM 3025 C CA  . ASP C 1 164 ? -23.734 8.457   -42.300 1.00 99.25  ? 362 ASP C CA  1 
ATOM 3026 C C   . ASP C 1 164 ? -24.849 8.788   -41.312 1.00 100.09 ? 362 ASP C C   1 
ATOM 3027 O O   . ASP C 1 164 ? -24.742 8.465   -40.125 1.00 102.07 ? 362 ASP C O   1 
ATOM 3028 C CB  . ASP C 1 164 ? -22.372 8.483   -41.603 1.00 104.43 ? 362 ASP C CB  1 
ATOM 3029 C CG  . ASP C 1 164 ? -21.628 9.793   -41.814 1.00 106.21 ? 362 ASP C CG  1 
ATOM 3030 O OD1 . ASP C 1 164 ? -21.954 10.521  -42.773 1.00 106.85 ? 362 ASP C OD1 1 
ATOM 3031 O OD2 . ASP C 1 164 ? -20.701 10.087  -41.027 1.00 102.39 ? 362 ASP C OD2 1 
ATOM 3032 N N   . PHE C 1 165 ? -25.925 9.417   -41.783 1.00 94.65  ? 363 PHE C N   1 
ATOM 3033 C CA  . PHE C 1 165 ? -27.068 9.751   -40.942 1.00 84.42  ? 363 PHE C CA  1 
ATOM 3034 C C   . PHE C 1 165 ? -28.056 8.593   -40.842 1.00 80.73  ? 363 PHE C C   1 
ATOM 3035 O O   . PHE C 1 165 ? -28.511 8.255   -39.745 1.00 78.46  ? 363 PHE C O   1 
ATOM 3036 C CB  . PHE C 1 165 ? -27.773 11.001  -41.483 1.00 82.11  ? 363 PHE C CB  1 
ATOM 3037 N N   . MET C 1 166 ? -28.398 7.978   -41.975 1.00 75.91  ? 364 MET C N   1 
ATOM 3038 C CA  . MET C 1 166 ? -29.379 6.901   -41.991 1.00 78.46  ? 364 MET C CA  1 
ATOM 3039 C C   . MET C 1 166 ? -28.764 5.523   -41.791 1.00 75.92  ? 364 MET C C   1 
ATOM 3040 O O   . MET C 1 166 ? -29.497 4.575   -41.489 1.00 79.97  ? 364 MET C O   1 
ATOM 3041 C CB  . MET C 1 166 ? -30.160 6.915   -43.309 1.00 81.12  ? 364 MET C CB  1 
ATOM 3042 C CG  . MET C 1 166 ? -30.901 8.213   -43.581 1.00 84.69  ? 364 MET C CG  1 
ATOM 3043 S SD  . MET C 1 166 ? -32.035 8.658   -42.252 1.00 90.90  ? 364 MET C SD  1 
ATOM 3044 C CE  . MET C 1 166 ? -33.119 7.233   -42.241 1.00 56.46  ? 364 MET C CE  1 
ATOM 3045 N N   . GLU C 1 167 ? -27.448 5.389   -41.952 1.00 76.79  ? 365 GLU C N   1 
ATOM 3046 C CA  . GLU C 1 167 ? -26.820 4.080   -41.801 1.00 81.04  ? 365 GLU C CA  1 
ATOM 3047 C C   . GLU C 1 167 ? -26.970 3.494   -40.400 1.00 80.02  ? 365 GLU C C   1 
ATOM 3048 O O   . GLU C 1 167 ? -27.250 2.287   -40.299 1.00 72.01  ? 365 GLU C O   1 
ATOM 3049 C CB  . GLU C 1 167 ? -25.342 4.162   -42.208 1.00 82.18  ? 365 GLU C CB  1 
ATOM 3050 C CG  . GLU C 1 167 ? -24.653 2.809   -42.316 1.00 80.28  ? 365 GLU C CG  1 
ATOM 3051 C CD  . GLU C 1 167 ? -25.219 1.950   -43.433 1.00 75.50  ? 365 GLU C CD  1 
ATOM 3052 O OE1 . GLU C 1 167 ? -25.787 2.512   -44.393 1.00 82.91  ? 365 GLU C OE1 1 
ATOM 3053 O OE2 . GLU C 1 167 ? -25.097 0.710   -43.349 1.00 85.32  ? 365 GLU C OE2 1 
ATOM 3054 N N   . PRO C 1 168 ? -26.796 4.245   -39.304 1.00 80.69  ? 366 PRO C N   1 
ATOM 3055 C CA  . PRO C 1 168 ? -27.100 3.660   -37.986 1.00 82.33  ? 366 PRO C CA  1 
ATOM 3056 C C   . PRO C 1 168 ? -28.552 3.247   -37.837 1.00 78.28  ? 366 PRO C C   1 
ATOM 3057 O O   . PRO C 1 168 ? -28.844 2.293   -37.104 1.00 76.47  ? 366 PRO C O   1 
ATOM 3058 C CB  . PRO C 1 168 ? -26.729 4.785   -37.009 1.00 78.07  ? 366 PRO C CB  1 
ATOM 3059 C CG  . PRO C 1 168 ? -25.734 5.604   -37.740 1.00 81.61  ? 366 PRO C CG  1 
ATOM 3060 C CD  . PRO C 1 168 ? -26.178 5.577   -39.171 1.00 87.19  ? 366 PRO C CD  1 
ATOM 3061 N N   . LYS C 1 169 ? -29.474 3.937   -38.512 1.00 77.63  ? 367 LYS C N   1 
ATOM 3062 C CA  . LYS C 1 169 ? -30.878 3.547   -38.454 1.00 61.58  ? 367 LYS C CA  1 
ATOM 3063 C C   . LYS C 1 169 ? -31.131 2.260   -39.229 1.00 62.89  ? 367 LYS C C   1 
ATOM 3064 O O   . LYS C 1 169 ? -31.992 1.464   -38.839 1.00 62.73  ? 367 LYS C O   1 
ATOM 3065 C CB  . LYS C 1 169 ? -31.769 4.672   -38.989 1.00 70.76  ? 367 LYS C CB  1 
ATOM 3066 C CG  . LYS C 1 169 ? -31.950 5.858   -38.044 1.00 62.66  ? 367 LYS C CG  1 
ATOM 3067 C CD  . LYS C 1 169 ? -30.733 6.771   -38.032 1.00 73.05  ? 367 LYS C CD  1 
ATOM 3068 C CE  . LYS C 1 169 ? -30.949 7.983   -37.142 1.00 76.03  ? 367 LYS C CE  1 
ATOM 3069 N NZ  . LYS C 1 169 ? -29.732 8.838   -37.065 1.00 85.21  ? 367 LYS C NZ  1 
ATOM 3070 N N   . PHE C 1 170 ? -30.397 2.040   -40.323 1.00 63.34  ? 368 PHE C N   1 
ATOM 3071 C CA  . PHE C 1 170 ? -30.546 0.797   -41.073 1.00 65.21  ? 368 PHE C CA  1 
ATOM 3072 C C   . PHE C 1 170 ? -30.039 -0.396  -40.273 1.00 67.99  ? 368 PHE C C   1 
ATOM 3073 O O   . PHE C 1 170 ? -30.616 -1.487  -40.345 1.00 63.98  ? 368 PHE C O   1 
ATOM 3074 C CB  . PHE C 1 170 ? -29.811 0.895   -42.411 1.00 69.57  ? 368 PHE C CB  1 
ATOM 3075 C CG  . PHE C 1 170 ? -30.620 1.531   -43.506 1.00 71.82  ? 368 PHE C CG  1 
ATOM 3076 C CD1 . PHE C 1 170 ? -31.598 0.808   -44.169 1.00 61.23  ? 368 PHE C CD1 1 
ATOM 3077 C CD2 . PHE C 1 170 ? -30.397 2.845   -43.880 1.00 63.21  ? 368 PHE C CD2 1 
ATOM 3078 C CE1 . PHE C 1 170 ? -32.344 1.387   -45.179 1.00 62.96  ? 368 PHE C CE1 1 
ATOM 3079 C CE2 . PHE C 1 170 ? -31.140 3.430   -44.889 1.00 68.52  ? 368 PHE C CE2 1 
ATOM 3080 C CZ  . PHE C 1 170 ? -32.114 2.699   -45.539 1.00 64.10  ? 368 PHE C CZ  1 
ATOM 3081 N N   . GLU C 1 171 ? -28.960 -0.209  -39.509 1.00 67.44  ? 369 GLU C N   1 
ATOM 3082 C CA  . GLU C 1 171 ? -28.434 -1.300  -38.695 1.00 75.34  ? 369 GLU C CA  1 
ATOM 3083 C C   . GLU C 1 171 ? -29.435 -1.722  -37.628 1.00 61.09  ? 369 GLU C C   1 
ATOM 3084 O O   . GLU C 1 171 ? -29.662 -2.919  -37.417 1.00 60.87  ? 369 GLU C O   1 
ATOM 3085 C CB  . GLU C 1 171 ? -27.110 -0.884  -38.053 1.00 80.14  ? 369 GLU C CB  1 
ATOM 3086 C CG  . GLU C 1 171 ? -26.001 -0.594  -39.049 1.00 87.64  ? 369 GLU C CG  1 
ATOM 3087 C CD  . GLU C 1 171 ? -24.768 -0.006  -38.391 1.00 96.90  ? 369 GLU C CD  1 
ATOM 3088 O OE1 . GLU C 1 171 ? -24.905 0.599   -37.307 1.00 94.32  ? 369 GLU C OE1 1 
ATOM 3089 O OE2 . GLU C 1 171 ? -23.662 -0.150  -38.955 1.00 118.67 ? 369 GLU C OE2 1 
ATOM 3090 N N   . PHE C 1 172 ? -30.049 -0.750  -36.949 1.00 61.40  ? 370 PHE C N   1 
ATOM 3091 C CA  . PHE C 1 172 ? -31.040 -1.071  -35.927 1.00 52.15  ? 370 PHE C CA  1 
ATOM 3092 C C   . PHE C 1 172 ? -32.303 -1.657  -36.544 1.00 61.22  ? 370 PHE C C   1 
ATOM 3093 O O   . PHE C 1 172 ? -32.934 -2.542  -35.954 1.00 60.25  ? 370 PHE C O   1 
ATOM 3094 C CB  . PHE C 1 172 ? -31.364 0.180   -35.112 1.00 52.71  ? 370 PHE C CB  1 
ATOM 3095 C CG  . PHE C 1 172 ? -32.644 0.087   -34.329 1.00 54.51  ? 370 PHE C CG  1 
ATOM 3096 C CD1 . PHE C 1 172 ? -32.687 -0.584  -33.118 1.00 57.58  ? 370 PHE C CD1 1 
ATOM 3097 C CD2 . PHE C 1 172 ? -33.803 0.685   -34.798 1.00 52.08  ? 370 PHE C CD2 1 
ATOM 3098 C CE1 . PHE C 1 172 ? -33.864 -0.666  -32.396 1.00 59.22  ? 370 PHE C CE1 1 
ATOM 3099 C CE2 . PHE C 1 172 ? -34.982 0.607   -34.081 1.00 57.71  ? 370 PHE C CE2 1 
ATOM 3100 C CZ  . PHE C 1 172 ? -35.013 -0.069  -32.878 1.00 47.10  ? 370 PHE C CZ  1 
ATOM 3101 N N   . ALA C 1 173 ? -32.686 -1.181  -37.732 1.00 57.75  ? 371 ALA C N   1 
ATOM 3102 C CA  . ALA C 1 173 ? -33.911 -1.663  -38.363 1.00 51.58  ? 371 ALA C CA  1 
ATOM 3103 C C   . ALA C 1 173 ? -33.803 -3.135  -38.738 1.00 55.11  ? 371 ALA C C   1 
ATOM 3104 O O   . ALA C 1 173 ? -34.775 -3.886  -38.603 1.00 62.65  ? 371 ALA C O   1 
ATOM 3105 C CB  . ALA C 1 173 ? -34.236 -0.819  -39.594 1.00 55.45  ? 371 ALA C CB  1 
ATOM 3106 N N   . VAL C 1 174 ? -32.633 -3.565  -39.216 1.00 52.13  ? 372 VAL C N   1 
ATOM 3107 C CA  . VAL C 1 174 ? -32.440 -4.976  -39.538 1.00 51.35  ? 372 VAL C CA  1 
ATOM 3108 C C   . VAL C 1 174 ? -32.516 -5.822  -38.273 1.00 52.99  ? 372 VAL C C   1 
ATOM 3109 O O   . VAL C 1 174 ? -33.079 -6.924  -38.279 1.00 56.05  ? 372 VAL C O   1 
ATOM 3110 C CB  . VAL C 1 174 ? -31.106 -5.178  -40.280 1.00 65.88  ? 372 VAL C CB  1 
ATOM 3111 C CG1 . VAL C 1 174 ? -30.854 -6.656  -40.536 1.00 65.99  ? 372 VAL C CG1 1 
ATOM 3112 C CG2 . VAL C 1 174 ? -31.107 -4.405  -41.589 1.00 59.10  ? 372 VAL C CG2 1 
ATOM 3113 N N   . LYS C 1 175 ? -31.962 -5.318  -37.168 1.00 59.28  ? 373 LYS C N   1 
ATOM 3114 C CA  . LYS C 1 175 ? -32.037 -6.045  -35.906 1.00 53.42  ? 373 LYS C CA  1 
ATOM 3115 C C   . LYS C 1 175 ? -33.443 -5.994  -35.321 1.00 59.34  ? 373 LYS C C   1 
ATOM 3116 O O   . LYS C 1 175 ? -33.937 -6.995  -34.790 1.00 55.63  ? 373 LYS C O   1 
ATOM 3117 C CB  . LYS C 1 175 ? -31.026 -5.477  -34.911 1.00 55.96  ? 373 LYS C CB  1 
ATOM 3118 C CG  . LYS C 1 175 ? -29.586 -5.485  -35.398 1.00 57.51  ? 373 LYS C CG  1 
ATOM 3119 C CD  . LYS C 1 175 ? -28.668 -4.805  -34.392 1.00 71.55  ? 373 LYS C CD  1 
ATOM 3120 C CE  . LYS C 1 175 ? -27.238 -4.731  -34.902 1.00 84.89  ? 373 LYS C CE  1 
ATOM 3121 N NZ  . LYS C 1 175 ? -26.653 -6.081  -35.125 1.00 87.41  ? 373 LYS C NZ  1 
ATOM 3122 N N   . PHE C 1 176 ? -34.104 -4.837  -35.410 1.00 53.13  ? 374 PHE C N   1 
ATOM 3123 C CA  . PHE C 1 176 ? -35.419 -4.688  -34.796 1.00 47.08  ? 374 PHE C CA  1 
ATOM 3124 C C   . PHE C 1 176 ? -36.485 -5.456  -35.567 1.00 49.21  ? 374 PHE C C   1 
ATOM 3125 O O   . PHE C 1 176 ? -37.371 -6.072  -34.963 1.00 52.30  ? 374 PHE C O   1 
ATOM 3126 C CB  . PHE C 1 176 ? -35.787 -3.207  -34.697 1.00 45.60  ? 374 PHE C CB  1 
ATOM 3127 C CG  . PHE C 1 176 ? -37.023 -2.942  -33.887 1.00 47.02  ? 374 PHE C CG  1 
ATOM 3128 C CD1 . PHE C 1 176 ? -36.965 -2.907  -32.503 1.00 45.80  ? 374 PHE C CD1 1 
ATOM 3129 C CD2 . PHE C 1 176 ? -38.241 -2.722  -34.507 1.00 33.38  ? 374 PHE C CD2 1 
ATOM 3130 C CE1 . PHE C 1 176 ? -38.099 -2.660  -31.754 1.00 32.87  ? 374 PHE C CE1 1 
ATOM 3131 C CE2 . PHE C 1 176 ? -39.379 -2.475  -33.762 1.00 32.46  ? 374 PHE C CE2 1 
ATOM 3132 C CZ  . PHE C 1 176 ? -39.307 -2.444  -32.384 1.00 48.16  ? 374 PHE C CZ  1 
ATOM 3133 N N   . ASN C 1 177 ? -36.421 -5.432  -36.901 1.00 48.78  ? 375 ASN C N   1 
ATOM 3134 C CA  . ASN C 1 177 ? -37.390 -6.173  -37.699 1.00 46.66  ? 375 ASN C CA  1 
ATOM 3135 C C   . ASN C 1 177 ? -37.209 -7.679  -37.577 1.00 39.98  ? 375 ASN C C   1 
ATOM 3136 O O   . ASN C 1 177 ? -38.142 -8.429  -37.885 1.00 46.72  ? 375 ASN C O   1 
ATOM 3137 C CB  . ASN C 1 177 ? -37.303 -5.754  -39.167 1.00 55.88  ? 375 ASN C CB  1 
ATOM 3138 C CG  . ASN C 1 177 ? -37.772 -4.330  -39.395 1.00 54.54  ? 375 ASN C CG  1 
ATOM 3139 O OD1 . ASN C 1 177 ? -38.563 -3.794  -38.618 1.00 62.55  ? 375 ASN C OD1 1 
ATOM 3140 N ND2 . ASN C 1 177 ? -37.289 -3.711  -40.466 1.00 47.25  ? 375 ASN C ND2 1 
ATOM 3141 N N   . ALA C 1 178 ? -36.035 -8.138  -37.137 1.00 51.61  ? 376 ALA C N   1 
ATOM 3142 C CA  . ALA C 1 178 ? -35.840 -9.561  -36.885 1.00 57.49  ? 376 ALA C CA  1 
ATOM 3143 C C   . ALA C 1 178 ? -36.718 -10.065 -35.749 1.00 57.89  ? 376 ALA C C   1 
ATOM 3144 O O   . ALA C 1 178 ? -36.969 -11.272 -35.661 1.00 64.45  ? 376 ALA C O   1 
ATOM 3145 C CB  . ALA C 1 178 ? -34.369 -9.845  -36.577 1.00 55.73  ? 376 ALA C CB  1 
ATOM 3146 N N   . LEU C 1 179 ? -37.189 -9.169  -34.877 1.00 50.14  ? 377 LEU C N   1 
ATOM 3147 C CA  . LEU C 1 179 ? -38.118 -9.565  -33.826 1.00 55.39  ? 377 LEU C CA  1 
ATOM 3148 C C   . LEU C 1 179 ? -39.503 -9.880  -34.376 1.00 49.25  ? 377 LEU C C   1 
ATOM 3149 O O   . LEU C 1 179 ? -40.301 -10.517 -33.680 1.00 50.86  ? 377 LEU C O   1 
ATOM 3150 C CB  . LEU C 1 179 ? -38.212 -8.465  -32.767 1.00 52.69  ? 377 LEU C CB  1 
ATOM 3151 C CG  . LEU C 1 179 ? -36.888 -8.042  -32.126 1.00 49.72  ? 377 LEU C CG  1 
ATOM 3152 C CD1 . LEU C 1 179 ? -37.115 -6.967  -31.075 1.00 51.50  ? 377 LEU C CD1 1 
ATOM 3153 C CD2 . LEU C 1 179 ? -36.175 -9.244  -31.526 1.00 55.82  ? 377 LEU C CD2 1 
ATOM 3154 N N   . GLU C 1 180 ? -39.800 -9.442  -35.602 1.00 51.40  ? 378 GLU C N   1 
ATOM 3155 C CA  . GLU C 1 180 ? -41.057 -9.755  -36.286 1.00 50.32  ? 378 GLU C CA  1 
ATOM 3156 C C   . GLU C 1 180 ? -42.270 -9.262  -35.500 1.00 49.98  ? 378 GLU C C   1 
ATOM 3157 O O   . GLU C 1 180 ? -43.285 -9.953  -35.393 1.00 54.17  ? 378 GLU C O   1 
ATOM 3158 C CB  . GLU C 1 180 ? -41.170 -11.252 -36.580 1.00 48.35  ? 378 GLU C CB  1 
ATOM 3159 C CG  . GLU C 1 180 ? -40.148 -11.761 -37.583 1.00 79.48  ? 378 GLU C CG  1 
ATOM 3160 C CD  . GLU C 1 180 ? -40.368 -13.214 -37.956 1.00 81.20  ? 378 GLU C CD  1 
ATOM 3161 O OE1 . GLU C 1 180 ? -41.195 -13.879 -37.299 1.00 79.52  ? 378 GLU C OE1 1 
ATOM 3162 O OE2 . GLU C 1 180 ? -39.717 -13.688 -38.911 1.00 97.07  ? 378 GLU C OE2 1 
ATOM 3163 N N   . LEU C 1 181 ? -42.169 -8.055  -34.953 1.00 47.66  ? 379 LEU C N   1 
ATOM 3164 C CA  . LEU C 1 181 ? -43.311 -7.443  -34.290 1.00 44.16  ? 379 LEU C CA  1 
ATOM 3165 C C   . LEU C 1 181 ? -44.318 -6.949  -35.323 1.00 49.04  ? 379 LEU C C   1 
ATOM 3166 O O   . LEU C 1 181 ? -43.970 -6.647  -36.467 1.00 49.22  ? 379 LEU C O   1 
ATOM 3167 C CB  . LEU C 1 181 ? -42.860 -6.277  -33.410 1.00 42.02  ? 379 LEU C CB  1 
ATOM 3168 C CG  . LEU C 1 181 ? -41.780 -6.546  -32.362 1.00 43.14  ? 379 LEU C CG  1 
ATOM 3169 C CD1 . LEU C 1 181 ? -41.411 -5.255  -31.653 1.00 41.06  ? 379 LEU C CD1 1 
ATOM 3170 C CD2 . LEU C 1 181 ? -42.240 -7.597  -31.363 1.00 46.51  ? 379 LEU C CD2 1 
ATOM 3171 N N   . ASP C 1 182 ? -45.578 -6.872  -34.912 1.00 43.58  ? 380 ASP C N   1 
ATOM 3172 C CA  . ASP C 1 182 ? -46.634 -6.317  -35.749 1.00 51.05  ? 380 ASP C CA  1 
ATOM 3173 C C   . ASP C 1 182 ? -47.203 -5.066  -35.079 1.00 52.05  ? 380 ASP C C   1 
ATOM 3174 O O   . ASP C 1 182 ? -46.706 -4.606  -34.047 1.00 52.32  ? 380 ASP C O   1 
ATOM 3175 C CB  . ASP C 1 182 ? -47.716 -7.365  -36.035 1.00 47.19  ? 380 ASP C CB  1 
ATOM 3176 C CG  . ASP C 1 182 ? -48.369 -7.908  -34.774 1.00 58.90  ? 380 ASP C CG  1 
ATOM 3177 O OD1 . ASP C 1 182 ? -48.060 -7.421  -33.669 1.00 55.19  ? 380 ASP C OD1 1 
ATOM 3178 O OD2 . ASP C 1 182 ? -49.199 -8.834  -34.891 1.00 54.66  ? 380 ASP C OD2 1 
ATOM 3179 N N   . ASP C 1 183 ? -48.261 -4.517  -35.681 1.00 47.31  ? 381 ASP C N   1 
ATOM 3180 C CA  . ASP C 1 183 ? -48.854 -3.288  -35.163 1.00 49.04  ? 381 ASP C CA  1 
ATOM 3181 C C   . ASP C 1 183 ? -49.439 -3.483  -33.771 1.00 46.77  ? 381 ASP C C   1 
ATOM 3182 O O   . ASP C 1 183 ? -49.437 -2.548  -32.962 1.00 51.16  ? 381 ASP C O   1 
ATOM 3183 C CB  . ASP C 1 183 ? -49.925 -2.780  -36.128 1.00 40.45  ? 381 ASP C CB  1 
ATOM 3184 C CG  . ASP C 1 183 ? -49.341 -2.287  -37.437 1.00 50.11  ? 381 ASP C CG  1 
ATOM 3185 O OD1 . ASP C 1 183 ? -48.255 -1.669  -37.408 1.00 42.46  ? 381 ASP C OD1 1 
ATOM 3186 O OD2 . ASP C 1 183 ? -49.963 -2.519  -38.494 1.00 66.97  ? 381 ASP C OD2 1 
ATOM 3187 N N   . SER C 1 184 ? -49.942 -4.683  -33.470 1.00 52.24  ? 382 SER C N   1 
ATOM 3188 C CA  . SER C 1 184 ? -50.468 -4.944  -32.134 1.00 49.82  ? 382 SER C CA  1 
ATOM 3189 C C   . SER C 1 184 ? -49.360 -4.906  -31.088 1.00 44.98  ? 382 SER C C   1 
ATOM 3190 O O   . SER C 1 184 ? -49.583 -4.466  -29.955 1.00 54.49  ? 382 SER C O   1 
ATOM 3191 C CB  . SER C 1 184 ? -51.187 -6.292  -32.105 1.00 42.57  ? 382 SER C CB  1 
ATOM 3192 O OG  . SER C 1 184 ? -52.282 -6.306  -33.004 1.00 71.46  ? 382 SER C OG  1 
ATOM 3193 N N   . ASP C 1 185 ? -48.160 -5.362  -31.451 1.00 42.72  ? 383 ASP C N   1 
ATOM 3194 C CA  . ASP C 1 185 ? -47.037 -5.326  -30.521 1.00 42.92  ? 383 ASP C CA  1 
ATOM 3195 C C   . ASP C 1 185 ? -46.440 -3.928  -30.420 1.00 48.61  ? 383 ASP C C   1 
ATOM 3196 O O   . ASP C 1 185 ? -46.054 -3.492  -29.330 1.00 45.14  ? 383 ASP C O   1 
ATOM 3197 C CB  . ASP C 1 185 ? -45.965 -6.329  -30.949 1.00 35.02  ? 383 ASP C CB  1 
ATOM 3198 C CG  . ASP C 1 185 ? -46.521 -7.722  -31.163 1.00 42.10  ? 383 ASP C CG  1 
ATOM 3199 O OD1 . ASP C 1 185 ? -47.565 -8.049  -30.560 1.00 48.26  ? 383 ASP C OD1 1 
ATOM 3200 O OD2 . ASP C 1 185 ? -45.917 -8.490  -31.941 1.00 44.76  ? 383 ASP C OD2 1 
ATOM 3201 N N   . LEU C 1 186 ? -46.356 -3.214  -31.545 1.00 37.11  ? 384 LEU C N   1 
ATOM 3202 C CA  . LEU C 1 186 ? -45.766 -1.879  -31.534 1.00 42.14  ? 384 LEU C CA  1 
ATOM 3203 C C   . LEU C 1 186 ? -46.658 -0.872  -30.821 1.00 43.23  ? 384 LEU C C   1 
ATOM 3204 O O   . LEU C 1 186 ? -46.151 0.078   -30.214 1.00 38.66  ? 384 LEU C O   1 
ATOM 3205 C CB  . LEU C 1 186 ? -45.482 -1.420  -32.964 1.00 41.14  ? 384 LEU C CB  1 
ATOM 3206 C CG  . LEU C 1 186 ? -44.447 -2.230  -33.749 1.00 49.88  ? 384 LEU C CG  1 
ATOM 3207 C CD1 . LEU C 1 186 ? -44.426 -1.803  -35.209 1.00 36.70  ? 384 LEU C CD1 1 
ATOM 3208 C CD2 . LEU C 1 186 ? -43.066 -2.087  -33.129 1.00 27.00  ? 384 LEU C CD2 1 
ATOM 3209 N N   . ALA C 1 187 ? -47.979 -1.059  -30.880 1.00 40.90  ? 385 ALA C N   1 
ATOM 3210 C CA  . ALA C 1 187 ? -48.889 -0.136  -30.208 1.00 35.54  ? 385 ALA C CA  1 
ATOM 3211 C C   . ALA C 1 187 ? -48.619 -0.084  -28.709 1.00 39.55  ? 385 ALA C C   1 
ATOM 3212 O O   . ALA C 1 187 ? -48.642 0.993   -28.103 1.00 43.40  ? 385 ALA C O   1 
ATOM 3213 C CB  . ALA C 1 187 ? -50.338 -0.539  -30.477 1.00 35.70  ? 385 ALA C CB  1 
ATOM 3214 N N   . ILE C 1 188 ? -48.357 -1.238  -28.097 1.00 38.60  ? 386 ILE C N   1 
ATOM 3215 C CA  . ILE C 1 188 ? -48.074 -1.275  -26.666 1.00 43.49  ? 386 ILE C CA  1 
ATOM 3216 C C   . ILE C 1 188 ? -46.635 -0.860  -26.391 1.00 38.91  ? 386 ILE C C   1 
ATOM 3217 O O   . ILE C 1 188 ? -46.357 -0.157  -25.413 1.00 44.14  ? 386 ILE C O   1 
ATOM 3218 C CB  . ILE C 1 188 ? -48.376 -2.676  -26.108 1.00 50.35  ? 386 ILE C CB  1 
ATOM 3219 C CG1 . ILE C 1 188 ? -49.697 -3.196  -26.674 1.00 37.99  ? 386 ILE C CG1 1 
ATOM 3220 C CG2 . ILE C 1 188 ? -48.421 -2.646  -24.588 1.00 37.18  ? 386 ILE C CG2 1 
ATOM 3221 C CD1 . ILE C 1 188 ? -49.960 -4.645  -26.356 1.00 40.59  ? 386 ILE C CD1 1 
ATOM 3222 N N   . PHE C 1 189 ? -45.702 -1.288  -27.245 1.00 45.14  ? 387 PHE C N   1 
ATOM 3223 C CA  . PHE C 1 189 ? -44.296 -0.950  -27.048 1.00 33.11  ? 387 PHE C CA  1 
ATOM 3224 C C   . PHE C 1 189 ? -44.068 0.553   -27.146 1.00 48.34  ? 387 PHE C C   1 
ATOM 3225 O O   . PHE C 1 189 ? -43.261 1.117   -26.398 1.00 49.06  ? 387 PHE C O   1 
ATOM 3226 C CB  . PHE C 1 189 ? -43.438 -1.698  -28.069 1.00 39.91  ? 387 PHE C CB  1 
ATOM 3227 C CG  . PHE C 1 189 ? -41.986 -1.314  -28.047 1.00 44.65  ? 387 PHE C CG  1 
ATOM 3228 C CD1 . PHE C 1 189 ? -41.187 -1.629  -26.961 1.00 38.39  ? 387 PHE C CD1 1 
ATOM 3229 C CD2 . PHE C 1 189 ? -41.416 -0.654  -29.123 1.00 48.82  ? 387 PHE C CD2 1 
ATOM 3230 C CE1 . PHE C 1 189 ? -39.849 -1.280  -26.943 1.00 40.24  ? 387 PHE C CE1 1 
ATOM 3231 C CE2 . PHE C 1 189 ? -40.078 -0.305  -29.111 1.00 50.97  ? 387 PHE C CE2 1 
ATOM 3232 C CZ  . PHE C 1 189 ? -39.294 -0.618  -28.020 1.00 44.05  ? 387 PHE C CZ  1 
ATOM 3233 N N   . ILE C 1 190 ? -44.776 1.220   -28.061 1.00 43.71  ? 388 ILE C N   1 
ATOM 3234 C CA  . ILE C 1 190 ? -44.656 2.670   -28.181 1.00 39.91  ? 388 ILE C CA  1 
ATOM 3235 C C   . ILE C 1 190 ? -45.199 3.355   -26.931 1.00 44.79  ? 388 ILE C C   1 
ATOM 3236 O O   . ILE C 1 190 ? -44.647 4.360   -26.466 1.00 39.52  ? 388 ILE C O   1 
ATOM 3237 C CB  . ILE C 1 190 ? -45.365 3.157   -29.461 1.00 43.70  ? 388 ILE C CB  1 
ATOM 3238 C CG1 . ILE C 1 190 ? -44.381 3.237   -30.635 1.00 53.34  ? 388 ILE C CG1 1 
ATOM 3239 C CG2 . ILE C 1 190 ? -46.027 4.512   -29.244 1.00 42.14  ? 388 ILE C CG2 1 
ATOM 3240 C CD1 . ILE C 1 190 ? -43.729 1.927   -31.013 1.00 54.02  ? 388 ILE C CD1 1 
ATOM 3241 N N   . ALA C 1 191 ? -46.275 2.812   -26.355 1.00 35.32  ? 389 ALA C N   1 
ATOM 3242 C CA  . ALA C 1 191 ? -46.845 3.400   -25.147 1.00 45.29  ? 389 ALA C CA  1 
ATOM 3243 C C   . ALA C 1 191 ? -45.897 3.266   -23.962 1.00 48.29  ? 389 ALA C C   1 
ATOM 3244 O O   . ALA C 1 191 ? -45.834 4.158   -23.107 1.00 48.80  ? 389 ALA C O   1 
ATOM 3245 C CB  . ALA C 1 191 ? -48.192 2.750   -24.832 1.00 39.98  ? 389 ALA C CB  1 
ATOM 3246 N N   . VAL C 1 192 ? -45.152 2.160   -23.892 1.00 39.71  ? 390 VAL C N   1 
ATOM 3247 C CA  . VAL C 1 192 ? -44.196 1.974   -22.804 1.00 47.91  ? 390 VAL C CA  1 
ATOM 3248 C C   . VAL C 1 192 ? -43.088 3.016   -22.883 1.00 49.56  ? 390 VAL C C   1 
ATOM 3249 O O   . VAL C 1 192 ? -42.626 3.534   -21.859 1.00 57.44  ? 390 VAL C O   1 
ATOM 3250 C CB  . VAL C 1 192 ? -43.630 0.541   -22.830 1.00 39.29  ? 390 VAL C CB  1 
ATOM 3251 C CG1 . VAL C 1 192 ? -42.559 0.372   -21.768 1.00 45.20  ? 390 VAL C CG1 1 
ATOM 3252 C CG2 . VAL C 1 192 ? -44.742 -0.474  -22.628 1.00 43.83  ? 390 VAL C CG2 1 
ATOM 3253 N N   . ILE C 1 193 ? -42.649 3.345   -24.100 1.00 45.61  ? 391 ILE C N   1 
ATOM 3254 C CA  . ILE C 1 193 ? -41.580 4.324   -24.269 1.00 46.58  ? 391 ILE C CA  1 
ATOM 3255 C C   . ILE C 1 193 ? -42.043 5.706   -23.823 1.00 49.79  ? 391 ILE C C   1 
ATOM 3256 O O   . ILE C 1 193 ? -41.279 6.463   -23.211 1.00 52.42  ? 391 ILE C O   1 
ATOM 3257 C CB  . ILE C 1 193 ? -41.097 4.334   -25.731 1.00 51.16  ? 391 ILE C CB  1 
ATOM 3258 C CG1 . ILE C 1 193 ? -40.571 2.957   -26.133 1.00 49.76  ? 391 ILE C CG1 1 
ATOM 3259 C CG2 . ILE C 1 193 ? -40.028 5.396   -25.939 1.00 45.32  ? 391 ILE C CG2 1 
ATOM 3260 C CD1 . ILE C 1 193 ? -40.141 2.875   -27.579 1.00 45.70  ? 391 ILE C CD1 1 
ATOM 3261 N N   . ILE C 1 194 ? -43.297 6.056   -24.116 1.00 50.68  ? 392 ILE C N   1 
ATOM 3262 C CA  . ILE C 1 194 ? -43.807 7.376   -23.756 1.00 50.72  ? 392 ILE C CA  1 
ATOM 3263 C C   . ILE C 1 194 ? -43.856 7.538   -22.242 1.00 57.62  ? 392 ILE C C   1 
ATOM 3264 O O   . ILE C 1 194 ? -43.462 8.578   -21.701 1.00 59.53  ? 392 ILE C O   1 
ATOM 3265 C CB  . ILE C 1 194 ? -45.189 7.607   -24.397 1.00 44.89  ? 392 ILE C CB  1 
ATOM 3266 C CG1 . ILE C 1 194 ? -45.066 7.659   -25.922 1.00 52.04  ? 392 ILE C CG1 1 
ATOM 3267 C CG2 . ILE C 1 194 ? -45.824 8.882   -23.862 1.00 50.33  ? 392 ILE C CG2 1 
ATOM 3268 C CD1 . ILE C 1 194 ? -46.377 7.914   -26.633 1.00 47.06  ? 392 ILE C CD1 1 
ATOM 3269 N N   . LEU C 1 195 ? -44.327 6.512   -21.536 1.00 54.03  ? 393 LEU C N   1 
ATOM 3270 C CA  . LEU C 1 195 ? -44.455 6.566   -20.079 1.00 55.99  ? 393 LEU C CA  1 
ATOM 3271 C C   . LEU C 1 195 ? -43.154 6.121   -19.405 1.00 55.74  ? 393 LEU C C   1 
ATOM 3272 O O   . LEU C 1 195 ? -43.120 5.208   -18.581 1.00 57.11  ? 393 LEU C O   1 
ATOM 3273 C CB  . LEU C 1 195 ? -45.636 5.716   -19.619 1.00 53.67  ? 393 LEU C CB  1 
ATOM 3274 C CG  . LEU C 1 195 ? -47.046 6.306   -19.722 1.00 58.04  ? 393 LEU C CG  1 
ATOM 3275 C CD1 . LEU C 1 195 ? -47.118 7.654   -19.017 1.00 61.96  ? 393 LEU C CD1 1 
ATOM 3276 C CD2 . LEU C 1 195 ? -47.516 6.422   -21.168 1.00 55.08  ? 393 LEU C CD2 1 
ATOM 3277 N N   . SER C 1 196 ? -42.068 6.798   -19.770 1.00 57.47  ? 394 SER C N   1 
ATOM 3278 C CA  . SER C 1 196 ? -40.754 6.524   -19.203 1.00 57.47  ? 394 SER C CA  1 
ATOM 3279 C C   . SER C 1 196 ? -40.551 7.391   -17.966 1.00 61.72  ? 394 SER C C   1 
ATOM 3280 O O   . SER C 1 196 ? -40.533 8.623   -18.061 1.00 62.45  ? 394 SER C O   1 
ATOM 3281 C CB  . SER C 1 196 ? -39.652 6.782   -20.229 1.00 59.52  ? 394 SER C CB  1 
ATOM 3282 O OG  . SER C 1 196 ? -39.769 5.902   -21.334 1.00 52.98  ? 394 SER C OG  1 
ATOM 3283 N N   . GLY C 1 197 ? -40.395 6.748   -16.810 1.00 66.49  ? 395 GLY C N   1 
ATOM 3284 C CA  . GLY C 1 197 ? -40.256 7.471   -15.559 1.00 58.02  ? 395 GLY C CA  1 
ATOM 3285 C C   . GLY C 1 197 ? -38.923 8.152   -15.342 1.00 64.51  ? 395 GLY C C   1 
ATOM 3286 O O   . GLY C 1 197 ? -38.794 8.933   -14.394 1.00 57.47  ? 395 GLY C O   1 
ATOM 3287 N N   . ASP C 1 198 ? -37.929 7.883   -16.189 1.00 65.36  ? 396 ASP C N   1 
ATOM 3288 C CA  . ASP C 1 198 ? -36.595 8.452   -16.035 1.00 66.43  ? 396 ASP C CA  1 
ATOM 3289 C C   . ASP C 1 198 ? -36.354 9.635   -16.968 1.00 68.86  ? 396 ASP C C   1 
ATOM 3290 O O   . ASP C 1 198 ? -35.208 9.908   -17.341 1.00 73.67  ? 396 ASP C O   1 
ATOM 3291 C CB  . ASP C 1 198 ? -35.529 7.380   -16.255 1.00 54.29  ? 396 ASP C CB  1 
ATOM 3292 C CG  . ASP C 1 198 ? -35.614 6.744   -17.630 1.00 77.63  ? 396 ASP C CG  1 
ATOM 3293 O OD1 . ASP C 1 198 ? -36.621 6.970   -18.333 1.00 77.96  ? 396 ASP C OD1 1 
ATOM 3294 O OD2 . ASP C 1 198 ? -34.668 6.020   -18.008 1.00 86.15  ? 396 ASP C OD2 1 
ATOM 3295 N N   . ARG C 1 199 ? -37.411 10.345  -17.353 1.00 58.88  ? 397 ARG C N   1 
ATOM 3296 C CA  . ARG C 1 199 ? -37.213 11.502  -18.215 1.00 64.18  ? 397 ARG C CA  1 
ATOM 3297 C C   . ARG C 1 199 ? -36.732 12.695  -17.390 1.00 72.69  ? 397 ARG C C   1 
ATOM 3298 O O   . ARG C 1 199 ? -37.240 12.937  -16.292 1.00 70.97  ? 397 ARG C O   1 
ATOM 3299 C CB  . ARG C 1 199 ? -38.503 11.860  -18.947 1.00 64.01  ? 397 ARG C CB  1 
ATOM 3300 C CG  . ARG C 1 199 ? -38.991 10.785  -19.904 1.00 56.03  ? 397 ARG C CG  1 
ATOM 3301 C CD  . ARG C 1 199 ? -37.887 10.346  -20.852 1.00 54.26  ? 397 ARG C CD  1 
ATOM 3302 N NE  . ARG C 1 199 ? -38.377 9.425   -21.873 1.00 60.93  ? 397 ARG C NE  1 
ATOM 3303 C CZ  . ARG C 1 199 ? -37.606 8.841   -22.783 1.00 57.99  ? 397 ARG C CZ  1 
ATOM 3304 N NH1 . ARG C 1 199 ? -36.301 9.078   -22.801 1.00 63.99  ? 397 ARG C NH1 1 
ATOM 3305 N NH2 . ARG C 1 199 ? -38.138 8.017   -23.676 1.00 57.30  ? 397 ARG C NH2 1 
ATOM 3306 N N   . PRO C 1 200 ? -35.751 13.448  -17.891 1.00 71.30  ? 398 PRO C N   1 
ATOM 3307 C CA  . PRO C 1 200 ? -35.222 14.592  -17.131 1.00 58.76  ? 398 PRO C CA  1 
ATOM 3308 C C   . PRO C 1 200 ? -36.279 15.674  -16.965 1.00 75.31  ? 398 PRO C C   1 
ATOM 3309 O O   . PRO C 1 200 ? -36.803 16.204  -17.947 1.00 72.20  ? 398 PRO C O   1 
ATOM 3310 C CB  . PRO C 1 200 ? -34.046 15.077  -17.991 1.00 61.14  ? 398 PRO C CB  1 
ATOM 3311 C CG  . PRO C 1 200 ? -33.708 13.916  -18.879 1.00 75.56  ? 398 PRO C CG  1 
ATOM 3312 C CD  . PRO C 1 200 ? -35.007 13.221  -19.140 1.00 68.06  ? 398 PRO C CD  1 
ATOM 3313 N N   . GLY C 1 201 ? -36.593 15.995  -15.716 1.00 72.70  ? 399 GLY C N   1 
ATOM 3314 C CA  . GLY C 1 201 ? -37.529 17.054  -15.409 1.00 62.24  ? 399 GLY C CA  1 
ATOM 3315 C C   . GLY C 1 201 ? -38.936 16.620  -15.063 1.00 74.01  ? 399 GLY C C   1 
ATOM 3316 O O   . GLY C 1 201 ? -39.839 17.464  -15.074 1.00 87.82  ? 399 GLY C O   1 
ATOM 3317 N N   . LEU C 1 202 ? -39.153 15.344  -14.758 1.00 69.61  ? 400 LEU C N   1 
ATOM 3318 C CA  . LEU C 1 202 ? -40.480 14.873  -14.389 1.00 72.14  ? 400 LEU C CA  1 
ATOM 3319 C C   . LEU C 1 202 ? -40.816 15.293  -12.964 1.00 81.90  ? 400 LEU C C   1 
ATOM 3320 O O   . LEU C 1 202 ? -39.971 15.231  -12.066 1.00 75.19  ? 400 LEU C O   1 
ATOM 3321 C CB  . LEU C 1 202 ? -40.568 13.353  -14.524 1.00 67.49  ? 400 LEU C CB  1 
ATOM 3322 C CG  . LEU C 1 202 ? -40.523 12.804  -15.951 1.00 76.55  ? 400 LEU C CG  1 
ATOM 3323 C CD1 . LEU C 1 202 ? -40.617 11.287  -15.945 1.00 72.21  ? 400 LEU C CD1 1 
ATOM 3324 C CD2 . LEU C 1 202 ? -41.636 13.410  -16.791 1.00 68.68  ? 400 LEU C CD2 1 
ATOM 3325 N N   . LEU C 1 203 ? -42.061 15.723  -12.762 1.00 83.12  ? 401 LEU C N   1 
ATOM 3326 C CA  . LEU C 1 203 ? -42.510 16.188  -11.453 1.00 79.84  ? 401 LEU C CA  1 
ATOM 3327 C C   . LEU C 1 203 ? -43.017 15.033  -10.592 1.00 86.12  ? 401 LEU C C   1 
ATOM 3328 O O   . LEU C 1 203 ? -42.508 14.800  -9.491  1.00 89.36  ? 401 LEU C O   1 
ATOM 3329 C CB  . LEU C 1 203 ? -43.600 17.253  -11.621 1.00 79.47  ? 401 LEU C CB  1 
ATOM 3330 C CG  . LEU C 1 203 ? -43.237 18.462  -12.485 1.00 90.05  ? 401 LEU C CG  1 
ATOM 3331 C CD1 . LEU C 1 203 ? -44.346 19.503  -12.447 1.00 87.18  ? 401 LEU C CD1 1 
ATOM 3332 C CD2 . LEU C 1 203 ? -41.911 19.063  -12.045 1.00 81.15  ? 401 LEU C CD2 1 
ATOM 3333 N N   . ASN C 1 204 ? -44.016 14.307  -11.082 1.00 85.84  ? 402 ASN C N   1 
ATOM 3334 C CA  . ASN C 1 204 ? -44.624 13.190  -10.363 1.00 75.14  ? 402 ASN C CA  1 
ATOM 3335 C C   . ASN C 1 204 ? -44.231 11.903  -11.085 1.00 69.42  ? 402 ASN C C   1 
ATOM 3336 O O   . ASN C 1 204 ? -44.917 11.452  -12.004 1.00 72.45  ? 402 ASN C O   1 
ATOM 3337 C CB  . ASN C 1 204 ? -46.139 13.356  -10.282 1.00 78.12  ? 402 ASN C CB  1 
ATOM 3338 C CG  . ASN C 1 204 ? -46.546 14.662  -9.628  1.00 82.76  ? 402 ASN C CG  1 
ATOM 3339 O OD1 . ASN C 1 204 ? -45.893 15.133  -8.696  1.00 92.64  ? 402 ASN C OD1 1 
ATOM 3340 N ND2 . ASN C 1 204 ? -47.627 15.258  -10.117 1.00 76.90  ? 402 ASN C ND2 1 
ATOM 3341 N N   . VAL C 1 205 ? -43.113 11.312  -10.657 1.00 63.00  ? 403 VAL C N   1 
ATOM 3342 C CA  . VAL C 1 205 ? -42.609 10.108  -11.310 1.00 63.62  ? 403 VAL C CA  1 
ATOM 3343 C C   . VAL C 1 205 ? -43.459 8.896   -10.949 1.00 66.32  ? 403 VAL C C   1 
ATOM 3344 O O   . VAL C 1 205 ? -43.601 7.968   -11.755 1.00 69.94  ? 403 VAL C O   1 
ATOM 3345 C CB  . VAL C 1 205 ? -41.129 9.893   -10.943 1.00 57.26  ? 403 VAL C CB  1 
ATOM 3346 C CG1 . VAL C 1 205 ? -40.562 8.681   -11.666 1.00 61.10  ? 403 VAL C CG1 1 
ATOM 3347 C CG2 . VAL C 1 205 ? -40.317 11.138  -11.267 1.00 60.69  ? 403 VAL C CG2 1 
ATOM 3348 N N   . LYS C 1 206 ? -44.046 8.885   -9.752  1.00 64.92  ? 404 LYS C N   1 
ATOM 3349 C CA  . LYS C 1 206 ? -44.784 7.707   -9.297  1.00 75.58  ? 404 LYS C CA  1 
ATOM 3350 C C   . LYS C 1 206 ? -45.989 7.374   -10.171 1.00 68.29  ? 404 LYS C C   1 
ATOM 3351 O O   . LYS C 1 206 ? -46.121 6.206   -10.574 1.00 59.62  ? 404 LYS C O   1 
ATOM 3352 C CB  . LYS C 1 206 ? -45.188 7.887   -7.830  1.00 67.31  ? 404 LYS C CB  1 
ATOM 3353 C CG  . LYS C 1 206 ? -45.866 6.669   -7.226  1.00 63.59  ? 404 LYS C CG  1 
ATOM 3354 C CD  . LYS C 1 206 ? -44.979 5.439   -7.339  1.00 68.79  ? 404 LYS C CD  1 
ATOM 3355 C CE  . LYS C 1 206 ? -45.670 4.203   -6.789  1.00 76.28  ? 404 LYS C CE  1 
ATOM 3356 N NZ  . LYS C 1 206 ? -44.812 2.991   -6.909  1.00 83.17  ? 404 LYS C NZ  1 
ATOM 3357 N N   . PRO C 1 207 ? -46.894 8.308   -10.500 1.00 67.42  ? 405 PRO C N   1 
ATOM 3358 C CA  . PRO C 1 207 ? -48.025 7.934   -11.367 1.00 65.28  ? 405 PRO C CA  1 
ATOM 3359 C C   . PRO C 1 207 ? -47.609 7.559   -12.778 1.00 67.22  ? 405 PRO C C   1 
ATOM 3360 O O   . PRO C 1 207 ? -48.366 6.856   -13.459 1.00 61.04  ? 405 PRO C O   1 
ATOM 3361 C CB  . PRO C 1 207 ? -48.908 9.189   -11.359 1.00 63.03  ? 405 PRO C CB  1 
ATOM 3362 C CG  . PRO C 1 207 ? -47.972 10.296  -11.065 1.00 73.35  ? 405 PRO C CG  1 
ATOM 3363 C CD  . PRO C 1 207 ? -46.973 9.726   -10.101 1.00 66.82  ? 405 PRO C CD  1 
ATOM 3364 N N   . ILE C 1 208 ? -46.438 8.001   -13.238 1.00 62.90  ? 406 ILE C N   1 
ATOM 3365 C CA  . ILE C 1 208 ? -45.965 7.603   -14.560 1.00 61.71  ? 406 ILE C CA  1 
ATOM 3366 C C   . ILE C 1 208 ? -45.527 6.144   -14.553 1.00 62.25  ? 406 ILE C C   1 
ATOM 3367 O O   . ILE C 1 208 ? -45.850 5.380   -15.471 1.00 57.05  ? 406 ILE C O   1 
ATOM 3368 C CB  . ILE C 1 208 ? -44.832 8.537   -15.025 1.00 65.48  ? 406 ILE C CB  1 
ATOM 3369 C CG1 . ILE C 1 208 ? -45.363 9.958   -15.225 1.00 62.16  ? 406 ILE C CG1 1 
ATOM 3370 C CG2 . ILE C 1 208 ? -44.194 8.013   -16.303 1.00 58.85  ? 406 ILE C CG2 1 
ATOM 3371 C CD1 . ILE C 1 208 ? -44.308 10.949  -15.663 1.00 64.79  ? 406 ILE C CD1 1 
ATOM 3372 N N   . GLU C 1 209 ? -44.793 5.730   -13.516 1.00 60.41  ? 407 GLU C N   1 
ATOM 3373 C CA  . GLU C 1 209 ? -44.366 4.338   -13.427 1.00 57.48  ? 407 GLU C CA  1 
ATOM 3374 C C   . GLU C 1 209 ? -45.544 3.402   -13.190 1.00 56.58  ? 407 GLU C C   1 
ATOM 3375 O O   . GLU C 1 209 ? -45.498 2.237   -13.600 1.00 62.63  ? 407 GLU C O   1 
ATOM 3376 C CB  . GLU C 1 209 ? -43.328 4.171   -12.317 1.00 53.25  ? 407 GLU C CB  1 
ATOM 3377 C CG  . GLU C 1 209 ? -42.130 5.098   -12.436 1.00 75.23  ? 407 GLU C CG  1 
ATOM 3378 C CD  . GLU C 1 209 ? -41.003 4.714   -11.497 1.00 101.31 ? 407 GLU C CD  1 
ATOM 3379 O OE1 . GLU C 1 209 ? -40.542 3.555   -11.564 1.00 108.17 ? 407 GLU C OE1 1 
ATOM 3380 O OE2 . GLU C 1 209 ? -40.584 5.566   -10.687 1.00 97.39  ? 407 GLU C OE2 1 
ATOM 3381 N N   . ASP C 1 210 ? -46.600 3.887   -12.531 1.00 57.48  ? 408 ASP C N   1 
ATOM 3382 C CA  . ASP C 1 210 ? -47.791 3.065   -12.340 1.00 56.66  ? 408 ASP C CA  1 
ATOM 3383 C C   . ASP C 1 210 ? -48.455 2.744   -13.672 1.00 62.97  ? 408 ASP C C   1 
ATOM 3384 O O   . ASP C 1 210 ? -48.953 1.630   -13.874 1.00 55.37  ? 408 ASP C O   1 
ATOM 3385 C CB  . ASP C 1 210 ? -48.773 3.771   -11.405 1.00 67.20  ? 408 ASP C CB  1 
ATOM 3386 C CG  . ASP C 1 210 ? -48.347 3.703   -9.952  1.00 71.70  ? 408 ASP C CG  1 
ATOM 3387 O OD1 . ASP C 1 210 ? -47.995 2.599   -9.486  1.00 73.35  ? 408 ASP C OD1 1 
ATOM 3388 O OD2 . ASP C 1 210 ? -48.361 4.753   -9.276  1.00 69.79  ? 408 ASP C OD2 1 
ATOM 3389 N N   . ILE C 1 211 ? -48.471 3.707   -14.594 1.00 59.96  ? 409 ILE C N   1 
ATOM 3390 C CA  . ILE C 1 211 ? -49.040 3.457   -15.913 1.00 58.02  ? 409 ILE C CA  1 
ATOM 3391 C C   . ILE C 1 211 ? -48.126 2.546   -16.723 1.00 55.87  ? 409 ILE C C   1 
ATOM 3392 O O   . ILE C 1 211 ? -48.593 1.634   -17.415 1.00 44.89  ? 409 ILE C O   1 
ATOM 3393 C CB  . ILE C 1 211 ? -49.306 4.788   -16.641 1.00 62.11  ? 409 ILE C CB  1 
ATOM 3394 C CG1 . ILE C 1 211 ? -50.238 5.672   -15.812 1.00 50.92  ? 409 ILE C CG1 1 
ATOM 3395 C CG2 . ILE C 1 211 ? -49.901 4.535   -18.018 1.00 49.34  ? 409 ILE C CG2 1 
ATOM 3396 C CD1 . ILE C 1 211 ? -50.470 7.044   -16.408 1.00 46.20  ? 409 ILE C CD1 1 
ATOM 3397 N N   . GLN C 1 212 ? -46.811 2.769   -16.642 1.00 49.57  ? 410 GLN C N   1 
ATOM 3398 C CA  . GLN C 1 212 ? -45.876 1.966   -17.424 1.00 48.36  ? 410 GLN C CA  1 
ATOM 3399 C C   . GLN C 1 212 ? -45.896 0.506   -16.988 1.00 56.18  ? 410 GLN C C   1 
ATOM 3400 O O   . GLN C 1 212 ? -45.802 -0.397  -17.827 1.00 52.58  ? 410 GLN C O   1 
ATOM 3401 C CB  . GLN C 1 212 ? -44.463 2.536   -17.309 1.00 49.64  ? 410 GLN C CB  1 
ATOM 3402 C CG  . GLN C 1 212 ? -43.465 1.894   -18.260 1.00 47.07  ? 410 GLN C CG  1 
ATOM 3403 C CD  . GLN C 1 212 ? -42.042 2.361   -18.025 1.00 57.25  ? 410 GLN C CD  1 
ATOM 3404 O OE1 . GLN C 1 212 ? -41.289 2.594   -18.970 1.00 64.48  ? 410 GLN C OE1 1 
ATOM 3405 N NE2 . GLN C 1 212 ? -41.665 2.494   -16.759 1.00 55.54  ? 410 GLN C NE2 1 
ATOM 3406 N N   . ASP C 1 213 ? -46.012 0.255   -15.681 1.00 54.46  ? 411 ASP C N   1 
ATOM 3407 C CA  . ASP C 1 213 ? -46.084 -1.122  -15.200 1.00 58.24  ? 411 ASP C CA  1 
ATOM 3408 C C   . ASP C 1 213 ? -47.310 -1.834  -15.759 1.00 53.50  ? 411 ASP C C   1 
ATOM 3409 O O   . ASP C 1 213 ? -47.244 -3.018  -16.107 1.00 51.50  ? 411 ASP C O   1 
ATOM 3410 C CB  . ASP C 1 213 ? -46.093 -1.151  -13.671 1.00 60.95  ? 411 ASP C CB  1 
ATOM 3411 C CG  . ASP C 1 213 ? -44.774 -0.698  -13.072 1.00 73.19  ? 411 ASP C CG  1 
ATOM 3412 O OD1 . ASP C 1 213 ? -43.891 -0.256  -13.837 1.00 71.67  ? 411 ASP C OD1 1 
ATOM 3413 O OD2 . ASP C 1 213 ? -44.620 -0.787  -11.836 1.00 76.98  ? 411 ASP C OD2 1 
ATOM 3414 N N   . ASN C 1 214 ? -48.438 -1.127  -15.855 1.00 52.66  ? 412 ASN C N   1 
ATOM 3415 C CA  . ASN C 1 214 ? -49.612 -1.698  -16.507 1.00 58.16  ? 412 ASN C CA  1 
ATOM 3416 C C   . ASN C 1 214 ? -49.347 -1.951  -17.985 1.00 51.47  ? 412 ASN C C   1 
ATOM 3417 O O   . ASN C 1 214 ? -49.772 -2.974  -18.535 1.00 48.29  ? 412 ASN C O   1 
ATOM 3418 C CB  . ASN C 1 214 ? -50.816 -0.774  -16.328 1.00 66.42  ? 412 ASN C CB  1 
ATOM 3419 C CG  . ASN C 1 214 ? -51.799 -1.292  -15.299 1.00 68.89  ? 412 ASN C CG  1 
ATOM 3420 O OD1 . ASN C 1 214 ? -51.618 -1.100  -14.097 1.00 80.80  ? 412 ASN C OD1 1 
ATOM 3421 N ND2 . ASN C 1 214 ? -52.852 -1.950  -15.768 1.00 89.40  ? 412 ASN C ND2 1 
ATOM 3422 N N   . LEU C 1 215 ? -48.645 -1.028  -18.646 1.00 50.22  ? 413 LEU C N   1 
ATOM 3423 C CA  . LEU C 1 215 ? -48.303 -1.225  -20.051 1.00 45.59  ? 413 LEU C CA  1 
ATOM 3424 C C   . LEU C 1 215 ? -47.273 -2.335  -20.216 1.00 47.03  ? 413 LEU C C   1 
ATOM 3425 O O   . LEU C 1 215 ? -47.326 -3.099  -21.187 1.00 37.35  ? 413 LEU C O   1 
ATOM 3426 C CB  . LEU C 1 215 ? -47.791 0.084   -20.651 1.00 47.69  ? 413 LEU C CB  1 
ATOM 3427 C CG  . LEU C 1 215 ? -48.765 1.264   -20.616 1.00 43.87  ? 413 LEU C CG  1 
ATOM 3428 C CD1 . LEU C 1 215 ? -48.076 2.549   -21.046 1.00 46.10  ? 413 LEU C CD1 1 
ATOM 3429 C CD2 . LEU C 1 215 ? -49.977 0.984   -21.489 1.00 48.21  ? 413 LEU C CD2 1 
ATOM 3430 N N   . LEU C 1 216 ? -46.328 -2.440  -19.279 1.00 46.01  ? 414 LEU C N   1 
ATOM 3431 C CA  . LEU C 1 216 ? -45.344 -3.517  -19.339 1.00 45.29  ? 414 LEU C CA  1 
ATOM 3432 C C   . LEU C 1 216 ? -46.001 -4.877  -19.134 1.00 43.16  ? 414 LEU C C   1 
ATOM 3433 O O   . LEU C 1 216 ? -45.603 -5.865  -19.761 1.00 49.26  ? 414 LEU C O   1 
ATOM 3434 C CB  . LEU C 1 216 ? -44.247 -3.286  -18.300 1.00 41.40  ? 414 LEU C CB  1 
ATOM 3435 C CG  . LEU C 1 216 ? -43.203 -2.223  -18.641 1.00 45.07  ? 414 LEU C CG  1 
ATOM 3436 C CD1 . LEU C 1 216 ? -42.352 -1.897  -17.424 1.00 44.23  ? 414 LEU C CD1 1 
ATOM 3437 C CD2 . LEU C 1 216 ? -42.330 -2.693  -19.794 1.00 34.88  ? 414 LEU C CD2 1 
ATOM 3438 N N   . GLN C 1 217 ? -47.007 -4.947  -18.260 1.00 42.96  ? 415 GLN C N   1 
ATOM 3439 C CA  . GLN C 1 217 ? -47.733 -6.199  -18.074 1.00 53.70  ? 415 GLN C CA  1 
ATOM 3440 C C   . GLN C 1 217 ? -48.555 -6.546  -19.309 1.00 44.42  ? 415 GLN C C   1 
ATOM 3441 O O   . GLN C 1 217 ? -48.618 -7.714  -19.711 1.00 49.46  ? 415 GLN C O   1 
ATOM 3442 C CB  . GLN C 1 217 ? -48.630 -6.108  -16.839 1.00 55.95  ? 415 GLN C CB  1 
ATOM 3443 C CG  . GLN C 1 217 ? -47.870 -6.041  -15.525 1.00 62.84  ? 415 GLN C CG  1 
ATOM 3444 C CD  . GLN C 1 217 ? -48.738 -5.574  -14.375 1.00 67.55  ? 415 GLN C CD  1 
ATOM 3445 O OE1 . GLN C 1 217 ? -49.948 -5.412  -14.522 1.00 71.68  ? 415 GLN C OE1 1 
ATOM 3446 N NE2 . GLN C 1 217 ? -48.120 -5.347  -13.221 1.00 65.63  ? 415 GLN C NE2 1 
ATOM 3447 N N   . ALA C 1 218 ? -49.191 -5.546  -19.924 1.00 44.84  ? 416 ALA C N   1 
ATOM 3448 C CA  . ALA C 1 218 ? -49.959 -5.797  -21.139 1.00 43.96  ? 416 ALA C CA  1 
ATOM 3449 C C   . ALA C 1 218 ? -49.047 -6.188  -22.295 1.00 47.18  ? 416 ALA C C   1 
ATOM 3450 O O   . ALA C 1 218 ? -49.419 -7.019  -23.132 1.00 51.84  ? 416 ALA C O   1 
ATOM 3451 C CB  . ALA C 1 218 ? -50.789 -4.566  -21.501 1.00 39.35  ? 416 ALA C CB  1 
ATOM 3452 N N   . LEU C 1 219 ? -47.850 -5.601  -22.356 1.00 40.93  ? 417 LEU C N   1 
ATOM 3453 C CA  . LEU C 1 219 ? -46.903 -5.966  -23.403 1.00 41.43  ? 417 LEU C CA  1 
ATOM 3454 C C   . LEU C 1 219 ? -46.396 -7.391  -23.215 1.00 44.54  ? 417 LEU C C   1 
ATOM 3455 O O   . LEU C 1 219 ? -46.263 -8.141  -24.189 1.00 51.62  ? 417 LEU C O   1 
ATOM 3456 C CB  . LEU C 1 219 ? -45.736 -4.979  -23.423 1.00 34.58  ? 417 LEU C CB  1 
ATOM 3457 C CG  . LEU C 1 219 ? -44.644 -5.242  -24.462 1.00 43.22  ? 417 LEU C CG  1 
ATOM 3458 C CD1 . LEU C 1 219 ? -45.214 -5.165  -25.869 1.00 35.05  ? 417 LEU C CD1 1 
ATOM 3459 C CD2 . LEU C 1 219 ? -43.489 -4.267  -24.292 1.00 39.95  ? 417 LEU C CD2 1 
ATOM 3460 N N   . GLU C 1 220 ? -46.113 -7.782  -21.970 1.00 51.33  ? 418 GLU C N   1 
ATOM 3461 C CA  . GLU C 1 220 ? -45.612 -9.129  -21.713 1.00 48.30  ? 418 GLU C CA  1 
ATOM 3462 C C   . GLU C 1 220 ? -46.648 -10.184 -22.079 1.00 43.70  ? 418 GLU C C   1 
ATOM 3463 O O   . GLU C 1 220 ? -46.308 -11.224 -22.654 1.00 51.56  ? 418 GLU C O   1 
ATOM 3464 C CB  . GLU C 1 220 ? -45.198 -9.263  -20.247 1.00 43.42  ? 418 GLU C CB  1 
ATOM 3465 C CG  . GLU C 1 220 ? -44.716 -10.652 -19.861 1.00 47.08  ? 418 GLU C CG  1 
ATOM 3466 C CD  . GLU C 1 220 ? -44.201 -10.717 -18.437 1.00 64.77  ? 418 GLU C CD  1 
ATOM 3467 O OE1 . GLU C 1 220 ? -43.290 -11.528 -18.169 1.00 66.04  ? 418 GLU C OE1 1 
ATOM 3468 O OE2 . GLU C 1 220 ? -44.703 -9.951  -17.587 1.00 55.57  ? 418 GLU C OE2 1 
ATOM 3469 N N   . LEU C 1 221 ? -47.919 -9.934  -21.756 1.00 45.01  ? 419 LEU C N   1 
ATOM 3470 C CA  . LEU C 1 221 ? -48.970 -10.875 -22.130 1.00 51.25  ? 419 LEU C CA  1 
ATOM 3471 C C   . LEU C 1 221 ? -49.205 -10.879 -23.635 1.00 52.07  ? 419 LEU C C   1 
ATOM 3472 O O   . LEU C 1 221 ? -49.527 -11.926 -24.208 1.00 52.15  ? 419 LEU C O   1 
ATOM 3473 C CB  . LEU C 1 221 ? -50.262 -10.539 -21.386 1.00 49.56  ? 419 LEU C CB  1 
ATOM 3474 C CG  . LEU C 1 221 ? -51.467 -11.446 -21.644 1.00 52.11  ? 419 LEU C CG  1 
ATOM 3475 C CD1 . LEU C 1 221 ? -51.109 -12.901 -21.388 1.00 41.63  ? 419 LEU C CD1 1 
ATOM 3476 C CD2 . LEU C 1 221 ? -52.643 -11.023 -20.778 1.00 62.57  ? 419 LEU C CD2 1 
ATOM 3477 N N   . GLN C 1 222 ? -49.046 -9.726  -24.288 1.00 55.99  ? 420 GLN C N   1 
ATOM 3478 C CA  . GLN C 1 222 ? -49.207 -9.663  -25.737 1.00 44.44  ? 420 GLN C CA  1 
ATOM 3479 C C   . GLN C 1 222 ? -48.118 -10.453 -26.451 1.00 51.63  ? 420 GLN C C   1 
ATOM 3480 O O   . GLN C 1 222 ? -48.403 -11.206 -27.390 1.00 51.78  ? 420 GLN C O   1 
ATOM 3481 C CB  . GLN C 1 222 ? -49.198 -8.205  -26.198 1.00 47.79  ? 420 GLN C CB  1 
ATOM 3482 C CG  . GLN C 1 222 ? -49.108 -8.018  -27.705 1.00 51.05  ? 420 GLN C CG  1 
ATOM 3483 C CD  . GLN C 1 222 ? -50.413 -8.315  -28.415 1.00 45.43  ? 420 GLN C CD  1 
ATOM 3484 O OE1 . GLN C 1 222 ? -51.479 -8.329  -27.800 1.00 51.88  ? 420 GLN C OE1 1 
ATOM 3485 N NE2 . GLN C 1 222 ? -50.336 -8.554  -29.719 1.00 46.50  ? 420 GLN C NE2 1 
ATOM 3486 N N   . LEU C 1 223 ? -46.864 -10.301 -26.018 1.00 54.86  ? 421 LEU C N   1 
ATOM 3487 C CA  . LEU C 1 223 ? -45.759 -10.962 -26.704 1.00 54.03  ? 421 LEU C CA  1 
ATOM 3488 C C   . LEU C 1 223 ? -45.765 -12.469 -26.476 1.00 55.43  ? 421 LEU C C   1 
ATOM 3489 O O   . LEU C 1 223 ? -45.314 -13.225 -27.344 1.00 59.01  ? 421 LEU C O   1 
ATOM 3490 C CB  . LEU C 1 223 ? -44.430 -10.356 -26.254 1.00 45.55  ? 421 LEU C CB  1 
ATOM 3491 C CG  . LEU C 1 223 ? -44.251 -8.877  -26.606 1.00 46.92  ? 421 LEU C CG  1 
ATOM 3492 C CD1 . LEU C 1 223 ? -42.969 -8.322  -26.008 1.00 44.81  ? 421 LEU C CD1 1 
ATOM 3493 C CD2 . LEU C 1 223 ? -44.270 -8.680  -28.114 1.00 44.17  ? 421 LEU C CD2 1 
ATOM 3494 N N   . LYS C 1 224 ? -46.266 -12.926 -25.326 1.00 54.26  ? 422 LYS C N   1 
ATOM 3495 C CA  . LYS C 1 224 ? -46.345 -14.362 -25.082 1.00 62.56  ? 422 LYS C CA  1 
ATOM 3496 C C   . LYS C 1 224 ? -47.417 -15.012 -25.948 1.00 55.99  ? 422 LYS C C   1 
ATOM 3497 O O   . LYS C 1 224 ? -47.216 -16.112 -26.475 1.00 57.21  ? 422 LYS C O   1 
ATOM 3498 C CB  . LYS C 1 224 ? -46.615 -14.635 -23.602 1.00 52.08  ? 422 LYS C CB  1 
ATOM 3499 C CG  . LYS C 1 224 ? -45.440 -14.339 -22.685 1.00 70.21  ? 422 LYS C CG  1 
ATOM 3500 C CD  . LYS C 1 224 ? -45.775 -14.671 -21.239 1.00 76.15  ? 422 LYS C CD  1 
ATOM 3501 C CE  . LYS C 1 224 ? -44.595 -14.400 -20.320 1.00 73.16  ? 422 LYS C CE  1 
ATOM 3502 N NZ  . LYS C 1 224 ? -44.919 -14.703 -18.898 1.00 91.41  ? 422 LYS C NZ  1 
ATOM 3503 N N   . LEU C 1 225 ? -48.562 -14.346 -26.108 1.00 56.99  ? 423 LEU C N   1 
ATOM 3504 C CA  . LEU C 1 225 ? -49.645 -14.905 -26.910 1.00 57.87  ? 423 LEU C CA  1 
ATOM 3505 C C   . LEU C 1 225 ? -49.362 -14.770 -28.402 1.00 58.89  ? 423 LEU C C   1 
ATOM 3506 O O   . LEU C 1 225 ? -49.489 -15.741 -29.156 1.00 66.76  ? 423 LEU C O   1 
ATOM 3507 C CB  . LEU C 1 225 ? -50.968 -14.224 -26.552 1.00 49.54  ? 423 LEU C CB  1 
ATOM 3508 C CG  . LEU C 1 225 ? -51.488 -14.444 -25.131 1.00 56.31  ? 423 LEU C CG  1 
ATOM 3509 C CD1 . LEU C 1 225 ? -52.717 -13.587 -24.870 1.00 59.36  ? 423 LEU C CD1 1 
ATOM 3510 C CD2 . LEU C 1 225 ? -51.798 -15.914 -24.897 1.00 42.64  ? 423 LEU C CD2 1 
ATOM 3511 N N   . ASN C 1 226 ? -48.975 -13.572 -28.844 1.00 58.76  ? 424 ASN C N   1 
ATOM 3512 C CA  . ASN C 1 226 ? -48.767 -13.333 -30.267 1.00 55.07  ? 424 ASN C CA  1 
ATOM 3513 C C   . ASN C 1 226 ? -47.511 -14.015 -30.796 1.00 61.49  ? 424 ASN C C   1 
ATOM 3514 O O   . ASN C 1 226 ? -47.426 -14.277 -32.000 1.00 70.78  ? 424 ASN C O   1 
ATOM 3515 C CB  . ASN C 1 226 ? -48.700 -11.830 -30.541 1.00 55.65  ? 424 ASN C CB  1 
ATOM 3516 C CG  . ASN C 1 226 ? -48.911 -11.493 -32.003 1.00 60.24  ? 424 ASN C CG  1 
ATOM 3517 O OD1 . ASN C 1 226 ? -49.476 -12.284 -32.759 1.00 58.76  ? 424 ASN C OD1 1 
ATOM 3518 N ND2 . ASN C 1 226 ? -48.461 -10.312 -32.409 1.00 53.59  ? 424 ASN C ND2 1 
ATOM 3519 N N   . HIS C 1 227 ? -46.541 -14.306 -29.932 1.00 56.25  ? 425 HIS C N   1 
ATOM 3520 C CA  . HIS C 1 227 ? -45.301 -14.972 -30.331 1.00 52.63  ? 425 HIS C CA  1 
ATOM 3521 C C   . HIS C 1 227 ? -44.958 -16.024 -29.285 1.00 60.24  ? 425 HIS C C   1 
ATOM 3522 O O   . HIS C 1 227 ? -44.068 -15.830 -28.450 1.00 62.17  ? 425 HIS C O   1 
ATOM 3523 C CB  . HIS C 1 227 ? -44.160 -13.965 -30.494 1.00 51.01  ? 425 HIS C CB  1 
ATOM 3524 C CG  . HIS C 1 227 ? -44.512 -12.785 -31.346 1.00 57.86  ? 425 HIS C CG  1 
ATOM 3525 N ND1 . HIS C 1 227 ? -44.307 -12.763 -32.708 1.00 63.79  ? 425 HIS C ND1 1 
ATOM 3526 C CD2 . HIS C 1 227 ? -45.058 -11.588 -31.028 1.00 54.34  ? 425 HIS C CD2 1 
ATOM 3527 C CE1 . HIS C 1 227 ? -44.711 -11.602 -33.193 1.00 55.02  ? 425 HIS C CE1 1 
ATOM 3528 N NE2 . HIS C 1 227 ? -45.171 -10.871 -32.194 1.00 56.87  ? 425 HIS C NE2 1 
ATOM 3529 N N   . PRO C 1 228 ? -45.654 -17.165 -29.308 1.00 67.87  ? 426 PRO C N   1 
ATOM 3530 C CA  . PRO C 1 228 ? -45.417 -18.174 -28.263 1.00 62.98  ? 426 PRO C CA  1 
ATOM 3531 C C   . PRO C 1 228 ? -44.084 -18.885 -28.401 1.00 60.76  ? 426 PRO C C   1 
ATOM 3532 O O   . PRO C 1 228 ? -43.548 -19.366 -27.395 1.00 72.53  ? 426 PRO C O   1 
ATOM 3533 C CB  . PRO C 1 228 ? -46.594 -19.140 -28.443 1.00 64.01  ? 426 PRO C CB  1 
ATOM 3534 C CG  . PRO C 1 228 ? -46.936 -19.029 -29.892 1.00 68.82  ? 426 PRO C CG  1 
ATOM 3535 C CD  . PRO C 1 228 ? -46.683 -17.592 -30.271 1.00 60.79  ? 426 PRO C CD  1 
ATOM 3536 N N   . GLU C 1 229 ? -43.532 -18.968 -29.607 1.00 56.56  ? 427 GLU C N   1 
ATOM 3537 C CA  . GLU C 1 229 ? -42.272 -19.661 -29.836 1.00 60.64  ? 427 GLU C CA  1 
ATOM 3538 C C   . GLU C 1 229 ? -41.064 -18.735 -29.773 1.00 62.02  ? 427 GLU C C   1 
ATOM 3539 O O   . GLU C 1 229 ? -39.931 -19.209 -29.909 1.00 64.14  ? 427 GLU C O   1 
ATOM 3540 C CB  . GLU C 1 229 ? -42.304 -20.375 -31.192 1.00 67.90  ? 427 GLU C CB  1 
ATOM 3541 C CG  . GLU C 1 229 ? -43.543 -21.232 -31.410 1.00 70.97  ? 427 GLU C CG  1 
ATOM 3542 C CD  . GLU C 1 229 ? -43.690 -22.330 -30.374 1.00 80.86  ? 427 GLU C CD  1 
ATOM 3543 O OE1 . GLU C 1 229 ? -42.657 -22.853 -29.903 1.00 83.20  ? 427 GLU C OE1 1 
ATOM 3544 O OE2 . GLU C 1 229 ? -44.841 -22.670 -30.026 1.00 86.36  ? 427 GLU C OE2 1 
ATOM 3545 N N   . SER C 1 230 ? -41.272 -17.436 -29.569 1.00 66.03  ? 428 SER C N   1 
ATOM 3546 C CA  . SER C 1 230 ? -40.180 -16.472 -29.489 1.00 61.85  ? 428 SER C CA  1 
ATOM 3547 C C   . SER C 1 230 ? -39.672 -16.434 -28.051 1.00 51.37  ? 428 SER C C   1 
ATOM 3548 O O   . SER C 1 230 ? -40.360 -15.937 -27.154 1.00 62.44  ? 428 SER C O   1 
ATOM 3549 C CB  . SER C 1 230 ? -40.644 -15.094 -29.952 1.00 49.20  ? 428 SER C CB  1 
ATOM 3550 O OG  . SER C 1 230 ? -39.554 -14.194 -30.044 1.00 70.51  ? 428 SER C OG  1 
ATOM 3551 N N   . SER C 1 231 ? -38.468 -16.957 -27.835 1.00 51.51  ? 429 SER C N   1 
ATOM 3552 C CA  . SER C 1 231 ? -37.906 -17.071 -26.495 1.00 67.14  ? 429 SER C CA  1 
ATOM 3553 C C   . SER C 1 231 ? -37.427 -15.708 -26.010 1.00 52.59  ? 429 SER C C   1 
ATOM 3554 O O   . SER C 1 231 ? -36.586 -15.073 -26.657 1.00 58.23  ? 429 SER C O   1 
ATOM 3555 C CB  . SER C 1 231 ? -36.758 -18.077 -26.484 1.00 62.02  ? 429 SER C CB  1 
ATOM 3556 O OG  . SER C 1 231 ? -36.151 -18.143 -25.206 1.00 64.13  ? 429 SER C OG  1 
ATOM 3557 N N   . GLN C 1 232 ? -37.963 -15.265 -24.870 1.00 63.33  ? 430 GLN C N   1 
ATOM 3558 C CA  . GLN C 1 232 ? -37.549 -14.018 -24.223 1.00 55.14  ? 430 GLN C CA  1 
ATOM 3559 C C   . GLN C 1 232 ? -37.690 -12.821 -25.161 1.00 56.01  ? 430 GLN C C   1 
ATOM 3560 O O   . GLN C 1 232 ? -36.855 -11.914 -25.169 1.00 50.41  ? 430 GLN C O   1 
ATOM 3561 C CB  . GLN C 1 232 ? -36.119 -14.124 -23.685 1.00 46.90  ? 430 GLN C CB  1 
ATOM 3562 C CG  . GLN C 1 232 ? -35.969 -15.076 -22.509 1.00 47.57  ? 430 GLN C CG  1 
ATOM 3563 C CD  . GLN C 1 232 ? -36.686 -14.583 -21.266 1.00 42.28  ? 430 GLN C CD  1 
ATOM 3564 O OE1 . GLN C 1 232 ? -37.316 -15.360 -20.549 1.00 52.75  ? 430 GLN C OE1 1 
ATOM 3565 N NE2 . GLN C 1 232 ? -36.587 -13.286 -21.002 1.00 46.09  ? 430 GLN C NE2 1 
ATOM 3566 N N   . LEU C 1 233 ? -38.758 -12.819 -25.963 1.00 51.50  ? 431 LEU C N   1 
ATOM 3567 C CA  . LEU C 1 233 ? -39.020 -11.675 -26.829 1.00 46.88  ? 431 LEU C CA  1 
ATOM 3568 C C   . LEU C 1 233 ? -39.292 -10.419 -26.014 1.00 45.32  ? 431 LEU C C   1 
ATOM 3569 O O   . LEU C 1 233 ? -38.926 -9.313  -26.431 1.00 46.65  ? 431 LEU C O   1 
ATOM 3570 C CB  . LEU C 1 233 ? -40.200 -11.976 -27.753 1.00 43.64  ? 431 LEU C CB  1 
ATOM 3571 C CG  . LEU C 1 233 ? -40.589 -10.875 -28.740 1.00 47.52  ? 431 LEU C CG  1 
ATOM 3572 C CD1 . LEU C 1 233 ? -39.438 -10.571 -29.687 1.00 43.06  ? 431 LEU C CD1 1 
ATOM 3573 C CD2 . LEU C 1 233 ? -41.838 -11.262 -29.513 1.00 53.37  ? 431 LEU C CD2 1 
ATOM 3574 N N   . PHE C 1 234 ? -39.927 -10.571 -24.851 1.00 41.51  ? 432 PHE C N   1 
ATOM 3575 C CA  . PHE C 1 234 ? -40.178 -9.430  -23.978 1.00 44.42  ? 432 PHE C CA  1 
ATOM 3576 C C   . PHE C 1 234 ? -38.873 -8.786  -23.527 1.00 41.09  ? 432 PHE C C   1 
ATOM 3577 O O   . PHE C 1 234 ? -38.741 -7.558  -23.544 1.00 47.11  ? 432 PHE C O   1 
ATOM 3578 C CB  . PHE C 1 234 ? -41.012 -9.876  -22.775 1.00 36.01  ? 432 PHE C CB  1 
ATOM 3579 C CG  . PHE C 1 234 ? -41.367 -8.764  -21.829 1.00 49.73  ? 432 PHE C CG  1 
ATOM 3580 C CD1 . PHE C 1 234 ? -42.146 -7.699  -22.252 1.00 42.52  ? 432 PHE C CD1 1 
ATOM 3581 C CD2 . PHE C 1 234 ? -40.943 -8.796  -20.510 1.00 48.81  ? 432 PHE C CD2 1 
ATOM 3582 C CE1 . PHE C 1 234 ? -42.481 -6.678  -21.382 1.00 45.35  ? 432 PHE C CE1 1 
ATOM 3583 C CE2 . PHE C 1 234 ? -41.276 -7.779  -19.635 1.00 40.17  ? 432 PHE C CE2 1 
ATOM 3584 C CZ  . PHE C 1 234 ? -42.046 -6.719  -20.071 1.00 51.63  ? 432 PHE C CZ  1 
ATOM 3585 N N   . ALA C 1 235 ? -37.891 -9.601  -23.136 1.00 36.16  ? 433 ALA C N   1 
ATOM 3586 C CA  . ALA C 1 235 ? -36.604 -9.054  -22.720 1.00 45.17  ? 433 ALA C CA  1 
ATOM 3587 C C   . ALA C 1 235 ? -35.839 -8.476  -23.903 1.00 41.33  ? 433 ALA C C   1 
ATOM 3588 O O   . ALA C 1 235 ? -35.199 -7.425  -23.780 1.00 49.73  ? 433 ALA C O   1 
ATOM 3589 C CB  . ALA C 1 235 ? -35.780 -10.133 -22.018 1.00 36.76  ? 433 ALA C CB  1 
ATOM 3590 N N   . LYS C 1 236 ? -35.891 -9.147  -25.057 1.00 47.56  ? 434 LYS C N   1 
ATOM 3591 C CA  . LYS C 1 236 ? -35.194 -8.645  -26.237 1.00 38.56  ? 434 LYS C CA  1 
ATOM 3592 C C   . LYS C 1 236 ? -35.791 -7.326  -26.713 1.00 48.16  ? 434 LYS C C   1 
ATOM 3593 O O   . LYS C 1 236 ? -35.066 -6.451  -27.199 1.00 46.88  ? 434 LYS C O   1 
ATOM 3594 C CB  . LYS C 1 236 ? -35.235 -9.683  -27.357 1.00 51.93  ? 434 LYS C CB  1 
ATOM 3595 C CG  . LYS C 1 236 ? -34.451 -10.952 -27.068 1.00 59.14  ? 434 LYS C CG  1 
ATOM 3596 C CD  . LYS C 1 236 ? -34.564 -11.935 -28.222 1.00 60.20  ? 434 LYS C CD  1 
ATOM 3597 C CE  . LYS C 1 236 ? -33.785 -13.207 -27.943 1.00 66.98  ? 434 LYS C CE  1 
ATOM 3598 N NZ  . LYS C 1 236 ? -33.900 -14.185 -29.060 1.00 84.74  ? 434 LYS C NZ  1 
ATOM 3599 N N   . LEU C 1 237 ? -37.110 -7.168  -26.585 1.00 42.33  ? 435 LEU C N   1 
ATOM 3600 C CA  . LEU C 1 237 ? -37.744 -5.916  -26.986 1.00 40.91  ? 435 LEU C CA  1 
ATOM 3601 C C   . LEU C 1 237 ? -37.332 -4.773  -26.067 1.00 48.75  ? 435 LEU C C   1 
ATOM 3602 O O   . LEU C 1 237 ? -37.060 -3.660  -26.534 1.00 46.64  ? 435 LEU C O   1 
ATOM 3603 C CB  . LEU C 1 237 ? -39.264 -6.077  -26.993 1.00 35.83  ? 435 LEU C CB  1 
ATOM 3604 C CG  . LEU C 1 237 ? -40.028 -5.556  -28.213 1.00 61.03  ? 435 LEU C CG  1 
ATOM 3605 C CD1 . LEU C 1 237 ? -41.504 -5.384  -27.885 1.00 55.31  ? 435 LEU C CD1 1 
ATOM 3606 C CD2 . LEU C 1 237 ? -39.432 -4.257  -28.736 1.00 48.09  ? 435 LEU C CD2 1 
ATOM 3607 N N   . LEU C 1 238 ? -37.275 -5.028  -24.758 1.00 47.68  ? 436 LEU C N   1 
ATOM 3608 C CA  . LEU C 1 238 ? -36.892 -3.983  -23.815 1.00 44.61  ? 436 LEU C CA  1 
ATOM 3609 C C   . LEU C 1 238 ? -35.433 -3.581  -23.980 1.00 39.66  ? 436 LEU C C   1 
ATOM 3610 O O   . LEU C 1 238 ? -35.074 -2.431  -23.703 1.00 39.31  ? 436 LEU C O   1 
ATOM 3611 C CB  . LEU C 1 238 ? -37.160 -4.447  -22.385 1.00 38.53  ? 436 LEU C CB  1 
ATOM 3612 C CG  . LEU C 1 238 ? -38.626 -4.725  -22.050 1.00 44.16  ? 436 LEU C CG  1 
ATOM 3613 C CD1 . LEU C 1 238 ? -38.751 -5.319  -20.660 1.00 50.90  ? 436 LEU C CD1 1 
ATOM 3614 C CD2 . LEU C 1 238 ? -39.456 -3.456  -22.174 1.00 49.36  ? 436 LEU C CD2 1 
ATOM 3615 N N   . GLN C 1 239 ? -34.579 -4.505  -24.428 1.00 41.94  ? 437 GLN C N   1 
ATOM 3616 C CA  . GLN C 1 239 ? -33.184 -4.162  -24.678 1.00 45.91  ? 437 GLN C CA  1 
ATOM 3617 C C   . GLN C 1 239 ? -33.034 -3.197  -25.845 1.00 57.13  ? 437 GLN C C   1 
ATOM 3618 O O   . GLN C 1 239 ? -32.038 -2.468  -25.909 1.00 53.91  ? 437 GLN C O   1 
ATOM 3619 C CB  . GLN C 1 239 ? -32.367 -5.428  -24.941 1.00 48.31  ? 437 GLN C CB  1 
ATOM 3620 C CG  . GLN C 1 239 ? -32.128 -6.289  -23.710 1.00 49.41  ? 437 GLN C CG  1 
ATOM 3621 C CD  . GLN C 1 239 ? -31.363 -7.556  -24.033 1.00 52.25  ? 437 GLN C CD  1 
ATOM 3622 O OE1 . GLN C 1 239 ? -31.613 -8.202  -25.050 1.00 65.09  ? 437 GLN C OE1 1 
ATOM 3623 N NE2 . GLN C 1 239 ? -30.418 -7.914  -23.172 1.00 55.71  ? 437 GLN C NE2 1 
ATOM 3624 N N   . LYS C 1 240 ? -34.001 -3.172  -26.766 1.00 50.95  ? 438 LYS C N   1 
ATOM 3625 C CA  . LYS C 1 240 ? -33.926 -2.264  -27.903 1.00 55.61  ? 438 LYS C CA  1 
ATOM 3626 C C   . LYS C 1 240 ? -34.041 -0.805  -27.487 1.00 49.07  ? 438 LYS C C   1 
ATOM 3627 O O   . LYS C 1 240 ? -33.586 0.072   -28.228 1.00 59.05  ? 438 LYS C O   1 
ATOM 3628 C CB  . LYS C 1 240 ? -35.014 -2.603  -28.921 1.00 44.56  ? 438 LYS C CB  1 
ATOM 3629 C CG  . LYS C 1 240 ? -34.913 -4.010  -29.484 1.00 48.75  ? 438 LYS C CG  1 
ATOM 3630 C CD  . LYS C 1 240 ? -33.548 -4.256  -30.108 1.00 42.23  ? 438 LYS C CD  1 
ATOM 3631 C CE  . LYS C 1 240 ? -33.424 -5.680  -30.626 1.00 51.57  ? 438 LYS C CE  1 
ATOM 3632 N NZ  . LYS C 1 240 ? -32.081 -5.943  -31.216 1.00 64.58  ? 438 LYS C NZ  1 
ATOM 3633 N N   . MET C 1 241 ? -34.640 -0.525  -26.326 1.00 53.84  ? 439 MET C N   1 
ATOM 3634 C CA  . MET C 1 241 ? -34.687 0.848   -25.836 1.00 56.84  ? 439 MET C CA  1 
ATOM 3635 C C   . MET C 1 241 ? -33.288 1.397   -25.590 1.00 63.55  ? 439 MET C C   1 
ATOM 3636 O O   . MET C 1 241 ? -33.064 2.605   -25.721 1.00 65.25  ? 439 MET C O   1 
ATOM 3637 C CB  . MET C 1 241 ? -35.522 0.926   -24.558 1.00 56.67  ? 439 MET C CB  1 
ATOM 3638 C CG  . MET C 1 241 ? -36.979 0.545   -24.746 1.00 47.59  ? 439 MET C CG  1 
ATOM 3639 S SD  . MET C 1 241 ? -37.930 0.695   -23.223 1.00 91.77  ? 439 MET C SD  1 
ATOM 3640 C CE  . MET C 1 241 ? -39.540 0.143   -23.775 1.00 54.47  ? 439 MET C CE  1 
ATOM 3641 N N   . THR C 1 242 ? -32.340 0.529   -25.231 1.00 57.00  ? 440 THR C N   1 
ATOM 3642 C CA  . THR C 1 242 ? -30.949 0.957   -25.126 1.00 68.01  ? 440 THR C CA  1 
ATOM 3643 C C   . THR C 1 242 ? -30.403 1.369   -26.487 1.00 63.72  ? 440 THR C C   1 
ATOM 3644 O O   . THR C 1 242 ? -29.683 2.369   -26.598 1.00 73.78  ? 440 THR C O   1 
ATOM 3645 C CB  . THR C 1 242 ? -30.098 -0.162  -24.524 1.00 70.61  ? 440 THR C CB  1 
ATOM 3646 O OG1 . THR C 1 242 ? -30.646 -0.557  -23.261 1.00 70.15  ? 440 THR C OG1 1 
ATOM 3647 C CG2 . THR C 1 242 ? -28.667 0.309   -24.321 1.00 61.71  ? 440 THR C CG2 1 
ATOM 3648 N N   . ASP C 1 243 ? -30.740 0.613   -27.535 1.00 61.92  ? 441 ASP C N   1 
ATOM 3649 C CA  . ASP C 1 243 ? -30.304 0.974   -28.879 1.00 67.18  ? 441 ASP C CA  1 
ATOM 3650 C C   . ASP C 1 243 ? -31.014 2.225   -29.380 1.00 59.98  ? 441 ASP C C   1 
ATOM 3651 O O   . ASP C 1 243 ? -30.433 3.000   -30.148 1.00 65.43  ? 441 ASP C O   1 
ATOM 3652 C CB  . ASP C 1 243 ? -30.541 -0.192  -29.837 1.00 56.97  ? 441 ASP C CB  1 
ATOM 3653 C CG  . ASP C 1 243 ? -30.026 -1.509  -29.289 1.00 69.84  ? 441 ASP C CG  1 
ATOM 3654 O OD1 . ASP C 1 243 ? -29.543 -1.527  -28.137 1.00 78.22  ? 441 ASP C OD1 1 
ATOM 3655 O OD2 . ASP C 1 243 ? -30.107 -2.528  -30.008 1.00 77.94  ? 441 ASP C OD2 1 
ATOM 3656 N N   . LEU C 1 244 ? -32.263 2.439   -28.959 1.00 56.95  ? 442 LEU C N   1 
ATOM 3657 C CA  . LEU C 1 244 ? -32.976 3.653   -29.345 1.00 53.95  ? 442 LEU C CA  1 
ATOM 3658 C C   . LEU C 1 244 ? -32.368 4.883   -28.683 1.00 65.38  ? 442 LEU C C   1 
ATOM 3659 O O   . LEU C 1 244 ? -32.221 5.929   -29.325 1.00 60.71  ? 442 LEU C O   1 
ATOM 3660 C CB  . LEU C 1 244 ? -34.456 3.527   -28.987 1.00 54.75  ? 442 LEU C CB  1 
ATOM 3661 C CG  . LEU C 1 244 ? -35.279 2.548   -29.825 1.00 56.12  ? 442 LEU C CG  1 
ATOM 3662 C CD1 . LEU C 1 244 ? -36.633 2.306   -29.181 1.00 41.16  ? 442 LEU C CD1 1 
ATOM 3663 C CD2 . LEU C 1 244 ? -35.444 3.076   -31.241 1.00 47.88  ? 442 LEU C CD2 1 
ATOM 3664 N N   . ARG C 1 245 ? -32.015 4.777   -27.399 1.00 62.44  ? 443 ARG C N   1 
ATOM 3665 C CA  . ARG C 1 245 ? -31.366 5.890   -26.713 1.00 54.70  ? 443 ARG C CA  1 
ATOM 3666 C C   . ARG C 1 245 ? -30.032 6.233   -27.361 1.00 66.20  ? 443 ARG C C   1 
ATOM 3667 O O   . ARG C 1 245 ? -29.656 7.408   -27.445 1.00 71.28  ? 443 ARG C O   1 
ATOM 3668 C CB  . ARG C 1 245 ? -31.167 5.553   -25.235 1.00 68.28  ? 443 ARG C CB  1 
ATOM 3669 C CG  . ARG C 1 245 ? -32.451 5.459   -24.428 1.00 67.85  ? 443 ARG C CG  1 
ATOM 3670 C CD  . ARG C 1 245 ? -32.997 6.833   -24.088 1.00 67.63  ? 443 ARG C CD  1 
ATOM 3671 N NE  . ARG C 1 245 ? -34.180 6.749   -23.237 1.00 75.66  ? 443 ARG C NE  1 
ATOM 3672 C CZ  . ARG C 1 245 ? -34.141 6.672   -21.910 1.00 74.53  ? 443 ARG C CZ  1 
ATOM 3673 N NH1 . ARG C 1 245 ? -32.975 6.667   -21.279 1.00 77.62  ? 443 ARG C NH1 1 
ATOM 3674 N NH2 . ARG C 1 245 ? -35.267 6.599   -21.215 1.00 74.16  ? 443 ARG C NH2 1 
ATOM 3675 N N   . GLN C 1 246 ? -29.302 5.218   -27.827 1.00 65.72  ? 444 GLN C N   1 
ATOM 3676 C CA  . GLN C 1 246 ? -28.013 5.468   -28.463 1.00 76.88  ? 444 GLN C CA  1 
ATOM 3677 C C   . GLN C 1 246 ? -28.186 6.162   -29.808 1.00 76.68  ? 444 GLN C C   1 
ATOM 3678 O O   . GLN C 1 246 ? -27.420 7.072   -30.143 1.00 83.08  ? 444 GLN C O   1 
ATOM 3679 C CB  . GLN C 1 246 ? -27.244 4.157   -28.629 1.00 79.34  ? 444 GLN C CB  1 
ATOM 3680 C CG  . GLN C 1 246 ? -25.893 4.313   -29.309 1.00 88.47  ? 444 GLN C CG  1 
ATOM 3681 C CD  . GLN C 1 246 ? -24.950 5.219   -28.538 1.00 98.36  ? 444 GLN C CD  1 
ATOM 3682 O OE1 . GLN C 1 246 ? -24.999 5.285   -27.310 1.00 94.65  ? 444 GLN C OE1 1 
ATOM 3683 N NE2 . GLN C 1 246 ? -24.087 5.925   -29.260 1.00 95.29  ? 444 GLN C NE2 1 
ATOM 3684 N N   . ILE C 1 247 ? -29.187 5.749   -30.590 1.00 69.82  ? 445 ILE C N   1 
ATOM 3685 C CA  . ILE C 1 247 ? -29.418 6.370   -31.891 1.00 70.50  ? 445 ILE C CA  1 
ATOM 3686 C C   . ILE C 1 247 ? -29.785 7.839   -31.725 1.00 67.26  ? 445 ILE C C   1 
ATOM 3687 O O   . ILE C 1 247 ? -29.303 8.702   -32.470 1.00 78.55  ? 445 ILE C O   1 
ATOM 3688 C CB  . ILE C 1 247 ? -30.500 5.600   -32.670 1.00 69.22  ? 445 ILE C CB  1 
ATOM 3689 C CG1 . ILE C 1 247 ? -29.972 4.234   -33.106 1.00 66.46  ? 445 ILE C CG1 1 
ATOM 3690 C CG2 . ILE C 1 247 ? -30.960 6.394   -33.880 1.00 72.02  ? 445 ILE C CG2 1 
ATOM 3691 C CD1 . ILE C 1 247 ? -30.913 3.496   -34.020 1.00 63.45  ? 445 ILE C CD1 1 
ATOM 3692 N N   . VAL C 1 248 ? -30.640 8.148   -30.748 1.00 68.81  ? 446 VAL C N   1 
ATOM 3693 C CA  . VAL C 1 248 ? -30.998 9.540   -30.484 1.00 70.23  ? 446 VAL C CA  1 
ATOM 3694 C C   . VAL C 1 248 ? -29.759 10.337  -30.092 1.00 81.33  ? 446 VAL C C   1 
ATOM 3695 O O   . VAL C 1 248 ? -29.531 11.448  -30.585 1.00 86.98  ? 446 VAL C O   1 
ATOM 3696 C CB  . VAL C 1 248 ? -32.089 9.620   -29.402 1.00 65.07  ? 446 VAL C CB  1 
ATOM 3697 C CG1 . VAL C 1 248 ? -32.365 11.070  -29.030 1.00 59.47  ? 446 VAL C CG1 1 
ATOM 3698 C CG2 . VAL C 1 248 ? -33.362 8.942   -29.883 1.00 59.78  ? 446 VAL C CG2 1 
ATOM 3699 N N   . THR C 1 249 ? -28.935 9.775   -29.205 1.00 76.92  ? 447 THR C N   1 
ATOM 3700 C CA  . THR C 1 249 ? -27.684 10.431  -28.843 1.00 81.16  ? 447 THR C CA  1 
ATOM 3701 C C   . THR C 1 249 ? -26.736 10.500  -30.035 1.00 83.87  ? 447 THR C C   1 
ATOM 3702 O O   . THR C 1 249 ? -26.064 11.517  -30.244 1.00 86.12  ? 447 THR C O   1 
ATOM 3703 C CB  . THR C 1 249 ? -27.025 9.698   -27.673 1.00 78.29  ? 447 THR C CB  1 
ATOM 3704 O OG1 . THR C 1 249 ? -27.943 9.624   -26.576 1.00 91.50  ? 447 THR C OG1 1 
ATOM 3705 C CG2 . THR C 1 249 ? -25.768 10.429  -27.223 1.00 78.52  ? 447 THR C CG2 1 
ATOM 3706 N N   . GLU C 1 250 ? -26.676 9.430   -30.833 1.00 81.67  ? 448 GLU C N   1 
ATOM 3707 C CA  . GLU C 1 250 ? -25.820 9.432   -32.014 1.00 84.68  ? 448 GLU C CA  1 
ATOM 3708 C C   . GLU C 1 250 ? -26.335 10.394  -33.078 1.00 86.46  ? 448 GLU C C   1 
ATOM 3709 O O   . GLU C 1 250 ? -25.543 10.939  -33.854 1.00 91.26  ? 448 GLU C O   1 
ATOM 3710 C CB  . GLU C 1 250 ? -25.710 8.016   -32.579 1.00 87.68  ? 448 GLU C CB  1 
ATOM 3711 C CG  . GLU C 1 250 ? -24.646 7.833   -33.646 1.00 96.57  ? 448 GLU C CG  1 
ATOM 3712 C CD  . GLU C 1 250 ? -24.505 6.385   -34.075 1.00 110.27 ? 448 GLU C CD  1 
ATOM 3713 O OE1 . GLU C 1 250 ? -25.282 5.540   -33.581 1.00 94.37  ? 448 GLU C OE1 1 
ATOM 3714 O OE2 . GLU C 1 250 ? -23.617 6.089   -34.902 1.00 124.70 ? 448 GLU C OE2 1 
ATOM 3715 N N   . HIS C 1 251 ? -27.650 10.618  -33.127 1.00 88.17  ? 449 HIS C N   1 
ATOM 3716 C CA  . HIS C 1 251 ? -28.211 11.552  -34.097 1.00 88.71  ? 449 HIS C CA  1 
ATOM 3717 C C   . HIS C 1 251 ? -27.973 12.999  -33.684 1.00 90.85  ? 449 HIS C C   1 
ATOM 3718 O O   . HIS C 1 251 ? -27.708 13.854  -34.537 1.00 93.27  ? 449 HIS C O   1 
ATOM 3719 C CB  . HIS C 1 251 ? -29.707 11.290  -34.275 1.00 99.64  ? 449 HIS C CB  1 
ATOM 3720 C CG  . HIS C 1 251 ? -30.366 12.193  -35.271 1.00 102.33 ? 449 HIS C CG  1 
ATOM 3721 N ND1 . HIS C 1 251 ? -30.166 12.075  -36.630 1.00 100.16 ? 449 HIS C ND1 1 
ATOM 3722 C CD2 . HIS C 1 251 ? -31.221 13.230  -35.106 1.00 94.65  ? 449 HIS C CD2 1 
ATOM 3723 C CE1 . HIS C 1 251 ? -30.870 12.999  -37.259 1.00 92.77  ? 449 HIS C CE1 1 
ATOM 3724 N NE2 . HIS C 1 251 ? -31.519 13.713  -36.357 1.00 91.93  ? 449 HIS C NE2 1 
ATOM 3725 N N   . VAL C 1 252 ? -28.066 13.292  -32.385 1.00 87.52  ? 450 VAL C N   1 
ATOM 3726 C CA  . VAL C 1 252 ? -27.822 14.652  -31.913 1.00 87.13  ? 450 VAL C CA  1 
ATOM 3727 C C   . VAL C 1 252 ? -26.362 15.035  -32.119 1.00 90.12  ? 450 VAL C C   1 
ATOM 3728 O O   . VAL C 1 252 ? -26.052 16.173  -32.491 1.00 89.94  ? 450 VAL C O   1 
ATOM 3729 C CB  . VAL C 1 252 ? -28.249 14.792  -30.440 1.00 92.75  ? 450 VAL C CB  1 
ATOM 3730 C CG1 . VAL C 1 252 ? -27.819 16.140  -29.883 1.00 83.17  ? 450 VAL C CG1 1 
ATOM 3731 C CG2 . VAL C 1 252 ? -29.754 14.623  -30.307 1.00 91.32  ? 450 VAL C CG2 1 
ATOM 3732 N N   . GLN C 1 253 ? -25.442 14.093  -31.892 1.00 89.64  ? 451 GLN C N   1 
ATOM 3733 C CA  . GLN C 1 253 ? -24.028 14.370  -32.129 1.00 94.01  ? 451 GLN C CA  1 
ATOM 3734 C C   . GLN C 1 253 ? -23.769 14.698  -33.594 1.00 103.02 ? 451 GLN C C   1 
ATOM 3735 O O   . GLN C 1 253 ? -22.993 15.608  -33.905 1.00 112.00 ? 451 GLN C O   1 
ATOM 3736 C CB  . GLN C 1 253 ? -23.175 13.183  -31.682 1.00 95.55  ? 451 GLN C CB  1 
ATOM 3737 C CG  . GLN C 1 253 ? -23.165 12.965  -30.180 1.00 97.09  ? 451 GLN C CG  1 
ATOM 3738 C CD  . GLN C 1 253 ? -22.290 11.801  -29.762 1.00 96.76  ? 451 GLN C CD  1 
ATOM 3739 O OE1 . GLN C 1 253 ? -21.743 11.085  -30.601 1.00 92.53  ? 451 GLN C OE1 1 
ATOM 3740 N NE2 . GLN C 1 253 ? -22.151 11.606  -28.456 1.00 103.14 ? 451 GLN C NE2 1 
ATOM 3741 N N   . LEU C 1 254 ? -24.410 13.967  -34.509 1.00 100.47 ? 452 LEU C N   1 
ATOM 3742 C CA  . LEU C 1 254 ? -24.349 14.335  -35.919 1.00 96.77  ? 452 LEU C CA  1 
ATOM 3743 C C   . LEU C 1 254 ? -25.155 15.590  -36.221 1.00 99.22  ? 452 LEU C C   1 
ATOM 3744 O O   . LEU C 1 254 ? -24.927 16.222  -37.256 1.00 102.90 ? 452 LEU C O   1 
ATOM 3745 C CB  . LEU C 1 254 ? -24.842 13.183  -36.798 1.00 94.70  ? 452 LEU C CB  1 
ATOM 3746 C CG  . LEU C 1 254 ? -24.007 11.903  -36.784 1.00 107.06 ? 452 LEU C CG  1 
ATOM 3747 C CD1 . LEU C 1 254 ? -24.635 10.836  -37.671 1.00 103.96 ? 452 LEU C CD1 1 
ATOM 3748 C CD2 . LEU C 1 254 ? -22.576 12.194  -37.215 1.00 105.21 ? 452 LEU C CD2 1 
ATOM 3749 N N   . LEU C 1 255 ? -26.094 15.959  -35.347 1.00 98.57  ? 453 LEU C N   1 
ATOM 3750 C CA  . LEU C 1 255 ? -26.853 17.193  -35.530 1.00 96.87  ? 453 LEU C CA  1 
ATOM 3751 C C   . LEU C 1 255 ? -26.071 18.425  -35.094 1.00 106.38 ? 453 LEU C C   1 
ATOM 3752 O O   . LEU C 1 255 ? -26.329 19.524  -35.593 1.00 108.96 ? 453 LEU C O   1 
ATOM 3753 C CB  . LEU C 1 255 ? -28.178 17.125  -34.764 1.00 97.44  ? 453 LEU C CB  1 
ATOM 3754 C CG  . LEU C 1 255 ? -29.456 17.173  -35.597 1.00 91.54  ? 453 LEU C CG  1 
ATOM 3755 C CD1 . LEU C 1 255 ? -30.498 18.043  -34.912 1.00 83.16  ? 453 LEU C CD1 1 
ATOM 3756 C CD2 . LEU C 1 255 ? -29.185 17.668  -37.016 1.00 92.65  ? 453 LEU C CD2 1 
ATOM 3757 N N   . GLN C 1 256 ? -25.134 18.264  -34.159 1.00 112.02 ? 454 GLN C N   1 
ATOM 3758 C CA  . GLN C 1 256 ? -24.274 19.368  -33.740 1.00 107.71 ? 454 GLN C CA  1 
ATOM 3759 C C   . GLN C 1 256 ? -23.208 19.666  -34.789 1.00 108.61 ? 454 GLN C C   1 
ATOM 3760 O O   . GLN C 1 256 ? -22.871 20.831  -35.027 1.00 104.36 ? 454 GLN C O   1 
ATOM 3761 C CB  . GLN C 1 256 ? -23.616 19.036  -32.397 1.00 103.27 ? 454 GLN C CB  1 
ATOM 3762 C CG  . GLN C 1 256 ? -24.590 18.686  -31.279 1.00 99.03  ? 454 GLN C CG  1 
ATOM 3763 C CD  . GLN C 1 256 ? -24.999 19.888  -30.452 1.00 107.97 ? 454 GLN C CD  1 
ATOM 3764 O OE1 . GLN C 1 256 ? -25.539 20.865  -30.972 1.00 110.68 ? 454 GLN C OE1 1 
ATOM 3765 N NE2 . GLN C 1 256 ? -24.740 19.822  -29.150 1.00 98.48  ? 454 GLN C NE2 1 
ATOM 3766 N N   . VAL C 1 257 ? -22.662 18.620  -35.417 1.00 106.34 ? 455 VAL C N   1 
ATOM 3767 C CA  . VAL C 1 257 ? -21.675 18.791  -36.481 1.00 105.68 ? 455 VAL C CA  1 
ATOM 3768 C C   . VAL C 1 257 ? -22.253 19.620  -37.623 1.00 109.61 ? 455 VAL C C   1 
ATOM 3769 O O   . VAL C 1 257 ? -21.545 20.423  -38.246 1.00 115.66 ? 455 VAL C O   1 
ATOM 3770 C CB  . VAL C 1 257 ? -21.187 17.409  -36.962 1.00 104.82 ? 455 VAL C CB  1 
ATOM 3771 C CG1 . VAL C 1 257 ? -20.227 17.541  -38.132 1.00 106.58 ? 455 VAL C CG1 1 
ATOM 3772 C CG2 . VAL C 1 257 ? -20.538 16.645  -35.820 1.00 99.75  ? 455 VAL C CG2 1 
ATOM 3773 N N   . ILE C 1 258 ? -23.546 19.441  -37.915 1.00 111.76 ? 456 ILE C N   1 
ATOM 3774 C CA  . ILE C 1 258 ? -24.170 20.200  -38.996 1.00 111.72 ? 456 ILE C CA  1 
ATOM 3775 C C   . ILE C 1 258 ? -24.361 21.659  -38.599 1.00 116.25 ? 456 ILE C C   1 
ATOM 3776 O O   . ILE C 1 258 ? -24.260 22.557  -39.444 1.00 118.49 ? 456 ILE C O   1 
ATOM 3777 C CB  . ILE C 1 258 ? -25.488 19.528  -39.426 1.00 102.87 ? 456 ILE C CB  1 
ATOM 3778 C CG1 . ILE C 1 258 ? -25.237 18.581  -40.596 1.00 104.55 ? 456 ILE C CG1 1 
ATOM 3779 C CG2 . ILE C 1 258 ? -26.530 20.562  -39.847 1.00 96.06  ? 456 ILE C CG2 1 
ATOM 3780 C CD1 . ILE C 1 258 ? -24.300 17.427  -40.302 1.00 104.20 ? 456 ILE C CD1 1 
ATOM 3781 N N   . LYS C 1 259 ? -24.600 21.928  -37.316 1.00 116.15 ? 457 LYS C N   1 
ATOM 3782 C CA  . LYS C 1 259 ? -24.657 23.299  -36.827 1.00 111.40 ? 457 LYS C CA  1 
ATOM 3783 C C   . LYS C 1 259 ? -23.289 23.970  -36.813 1.00 118.07 ? 457 LYS C C   1 
ATOM 3784 O O   . LYS C 1 259 ? -23.216 25.195  -36.662 1.00 115.94 ? 457 LYS C O   1 
ATOM 3785 C CB  . LYS C 1 259 ? -25.259 23.333  -35.416 1.00 107.10 ? 457 LYS C CB  1 
ATOM 3786 C CG  . LYS C 1 259 ? -25.721 24.719  -34.991 1.00 103.05 ? 457 LYS C CG  1 
ATOM 3787 C CD  . LYS C 1 259 ? -25.822 24.872  -33.489 1.00 102.22 ? 457 LYS C CD  1 
ATOM 3788 C CE  . LYS C 1 259 ? -25.855 26.342  -33.131 1.00 104.82 ? 457 LYS C CE  1 
ATOM 3789 N NZ  . LYS C 1 259 ? -24.606 27.014  -33.574 1.00 92.47  ? 457 LYS C NZ  1 
ATOM 3790 N N   . LYS C 1 260 ? -22.211 23.203  -36.970 1.00 127.78 ? 458 LYS C N   1 
ATOM 3791 C CA  . LYS C 1 260 ? -20.864 23.755  -36.912 1.00 122.52 ? 458 LYS C CA  1 
ATOM 3792 C C   . LYS C 1 260 ? -20.208 23.786  -38.292 1.00 122.14 ? 458 LYS C C   1 
ATOM 3793 O O   . LYS C 1 260 ? -20.267 24.806  -38.983 1.00 122.87 ? 458 LYS C O   1 
ATOM 3794 C CB  . LYS C 1 260 ? -20.011 22.957  -35.922 1.00 117.50 ? 458 LYS C CB  1 
ATOM 3795 N N   . THR C 1 261 ? -19.604 22.667  -38.711 1.00 122.21 ? 459 THR C N   1 
ATOM 3796 C CA  . THR C 1 261 ? -18.760 22.654  -39.909 1.00 123.82 ? 459 THR C CA  1 
ATOM 3797 C C   . THR C 1 261 ? -19.528 23.022  -41.178 1.00 120.35 ? 459 THR C C   1 
ATOM 3798 O O   . THR C 1 261 ? -18.936 23.580  -42.112 1.00 123.78 ? 459 THR C O   1 
ATOM 3799 C CB  . THR C 1 261 ? -18.083 21.278  -40.057 1.00 123.01 ? 459 THR C CB  1 
ATOM 3800 O OG1 . THR C 1 261 ? -16.656 21.434  -40.032 1.00 118.27 ? 459 THR C OG1 1 
ATOM 3801 C CG2 . THR C 1 261 ? -18.483 20.580  -41.362 1.00 117.01 ? 459 THR C CG2 1 
ATOM 3802 N N   . GLU C 1 262 ? -20.832 22.742  -41.230 1.00 115.87 ? 460 GLU C N   1 
ATOM 3803 C CA  . GLU C 1 262 ? -21.624 22.995  -42.434 1.00 117.64 ? 460 GLU C CA  1 
ATOM 3804 C C   . GLU C 1 262 ? -21.797 24.491  -42.687 1.00 113.47 ? 460 GLU C C   1 
ATOM 3805 O O   . GLU C 1 262 ? -22.851 25.064  -42.400 1.00 110.74 ? 460 GLU C O   1 
ATOM 3806 C CB  . GLU C 1 262 ? -22.994 22.318  -42.333 1.00 119.68 ? 460 GLU C CB  1 
ATOM 3807 C CG  . GLU C 1 262 ? -23.712 22.155  -43.660 1.00 114.75 ? 460 GLU C CG  1 
ATOM 3808 C CD  . GLU C 1 262 ? -22.849 21.463  -44.700 1.00 112.61 ? 460 GLU C CD  1 
ATOM 3809 O OE1 . GLU C 1 262 ? -22.353 22.142  -45.624 1.00 114.63 ? 460 GLU C OE1 1 
ATOM 3810 O OE2 . GLU C 1 262 ? -22.657 20.235  -44.589 1.00 106.33 ? 460 GLU C OE2 1 
ATOM 3811 N N   . GLY D 2 4   ? -38.632 25.080  -29.142 1.00 90.94  ? 140 GLY D N   1 
ATOM 3812 C CA  . GLY D 2 4   ? -39.000 24.891  -30.533 1.00 97.78  ? 140 GLY D CA  1 
ATOM 3813 C C   . GLY D 2 4   ? -39.938 23.718  -30.742 1.00 100.09 ? 140 GLY D C   1 
ATOM 3814 O O   . GLY D 2 4   ? -41.142 23.902  -30.929 1.00 93.58  ? 140 GLY D O   1 
ATOM 3815 N N   . LEU D 2 5   ? -39.378 22.505  -30.714 1.00 109.99 ? 141 LEU D N   1 
ATOM 3816 C CA  . LEU D 2 5   ? -40.199 21.304  -30.830 1.00 94.17  ? 141 LEU D CA  1 
ATOM 3817 C C   . LEU D 2 5   ? -41.204 21.204  -29.690 1.00 86.11  ? 141 LEU D C   1 
ATOM 3818 O O   . LEU D 2 5   ? -42.276 20.610  -29.855 1.00 74.78  ? 141 LEU D O   1 
ATOM 3819 C CB  . LEU D 2 5   ? -39.302 20.064  -30.873 1.00 93.23  ? 141 LEU D CB  1 
ATOM 3820 C CG  . LEU D 2 5   ? -39.949 18.678  -30.784 1.00 91.10  ? 141 LEU D CG  1 
ATOM 3821 C CD1 . LEU D 2 5   ? -39.347 17.730  -31.810 1.00 92.33  ? 141 LEU D CD1 1 
ATOM 3822 C CD2 . LEU D 2 5   ? -39.819 18.107  -29.376 1.00 87.19  ? 141 LEU D CD2 1 
ATOM 3823 N N   . GLU D 2 6   ? -40.883 21.791  -28.535 1.00 95.74  ? 142 GLU D N   1 
ATOM 3824 C CA  . GLU D 2 6   ? -41.805 21.813  -27.408 1.00 85.93  ? 142 GLU D CA  1 
ATOM 3825 C C   . GLU D 2 6   ? -43.064 22.622  -27.697 1.00 88.54  ? 142 GLU D C   1 
ATOM 3826 O O   . GLU D 2 6   ? -44.017 22.553  -26.913 1.00 90.30  ? 142 GLU D O   1 
ATOM 3827 C CB  . GLU D 2 6   ? -41.091 22.371  -26.173 1.00 95.43  ? 142 GLU D CB  1 
ATOM 3828 C CG  . GLU D 2 6   ? -41.651 21.886  -24.848 1.00 102.29 ? 142 GLU D CG  1 
ATOM 3829 C CD  . GLU D 2 6   ? -40.767 22.255  -23.673 1.00 101.38 ? 142 GLU D CD  1 
ATOM 3830 O OE1 . GLU D 2 6   ? -41.297 22.760  -22.661 1.00 112.69 ? 142 GLU D OE1 1 
ATOM 3831 O OE2 . GLU D 2 6   ? -39.539 22.043  -23.764 1.00 100.38 ? 142 GLU D OE2 1 
ATOM 3832 N N   . ALA D 2 7   ? -43.091 23.381  -28.794 1.00 90.25  ? 143 ALA D N   1 
ATOM 3833 C CA  . ALA D 2 7   ? -44.267 24.155  -29.170 1.00 85.10  ? 143 ALA D CA  1 
ATOM 3834 C C   . ALA D 2 7   ? -45.224 23.379  -30.062 1.00 89.88  ? 143 ALA D C   1 
ATOM 3835 O O   . ALA D 2 7   ? -46.433 23.633  -30.024 1.00 86.00  ? 143 ALA D O   1 
ATOM 3836 C CB  . ALA D 2 7   ? -43.847 25.447  -29.874 1.00 94.68  ? 143 ALA D CB  1 
ATOM 3837 N N   . ILE D 2 8   ? -44.717 22.448  -30.873 1.00 88.79  ? 144 ILE D N   1 
ATOM 3838 C CA  . ILE D 2 8   ? -45.602 21.567  -31.630 1.00 81.76  ? 144 ILE D CA  1 
ATOM 3839 C C   . ILE D 2 8   ? -46.390 20.678  -30.678 1.00 79.15  ? 144 ILE D C   1 
ATOM 3840 O O   . ILE D 2 8   ? -47.618 20.569  -30.773 1.00 74.11  ? 144 ILE D O   1 
ATOM 3841 C CB  . ILE D 2 8   ? -44.797 20.740  -32.647 1.00 86.03  ? 144 ILE D CB  1 
ATOM 3842 C CG1 . ILE D 2 8   ? -43.924 21.661  -33.502 1.00 84.58  ? 144 ILE D CG1 1 
ATOM 3843 C CG2 . ILE D 2 8   ? -45.731 19.927  -33.530 1.00 83.88  ? 144 ILE D CG2 1 
ATOM 3844 C CD1 . ILE D 2 8   ? -43.038 20.927  -34.483 1.00 95.95  ? 144 ILE D CD1 1 
ATOM 3845 N N   . ILE D 2 9   ? -45.692 20.021  -29.748 1.00 82.12  ? 145 ILE D N   1 
ATOM 3846 C CA  . ILE D 2 9   ? -46.362 19.487  -28.576 1.00 79.24  ? 145 ILE D CA  1 
ATOM 3847 C C   . ILE D 2 9   ? -46.974 20.658  -27.805 1.00 80.76  ? 145 ILE D C   1 
ATOM 3848 O O   . ILE D 2 9   ? -46.538 21.809  -27.925 1.00 94.76  ? 145 ILE D O   1 
ATOM 3849 C CB  . ILE D 2 9   ? -45.382 18.685  -27.705 1.00 75.78  ? 145 ILE D CB  1 
ATOM 3850 C CG1 . ILE D 2 9   ? -44.500 17.799  -28.588 1.00 70.01  ? 145 ILE D CG1 1 
ATOM 3851 C CG2 . ILE D 2 9   ? -46.126 17.827  -26.692 1.00 61.43  ? 145 ILE D CG2 1 
ATOM 3852 C CD1 . ILE D 2 9   ? -43.423 17.055  -27.831 1.00 75.10  ? 145 ILE D CD1 1 
ATOM 3853 N N   . ARG D 2 10  ? -48.011 20.350  -27.014 1.00 83.18  ? 146 ARG D N   1 
ATOM 3854 C CA  . ARG D 2 10  ? -48.884 21.320  -26.349 1.00 87.73  ? 146 ARG D CA  1 
ATOM 3855 C C   . ARG D 2 10  ? -49.903 21.880  -27.333 1.00 86.77  ? 146 ARG D C   1 
ATOM 3856 O O   . ARG D 2 10  ? -51.101 21.911  -27.035 1.00 88.07  ? 146 ARG D O   1 
ATOM 3857 C CB  . ARG D 2 10  ? -48.099 22.470  -25.706 1.00 86.51  ? 146 ARG D CB  1 
ATOM 3858 C CG  . ARG D 2 10  ? -47.973 22.416  -24.199 1.00 85.42  ? 146 ARG D CG  1 
ATOM 3859 C CD  . ARG D 2 10  ? -47.240 23.652  -23.703 1.00 99.32  ? 146 ARG D CD  1 
ATOM 3860 N NE  . ARG D 2 10  ? -47.447 23.892  -22.280 1.00 106.02 ? 146 ARG D NE  1 
ATOM 3861 C CZ  . ARG D 2 10  ? -46.581 23.559  -21.330 1.00 110.14 ? 146 ARG D CZ  1 
ATOM 3862 N NH1 . ARG D 2 10  ? -45.437 22.967  -21.649 1.00 107.18 ? 146 ARG D NH1 1 
ATOM 3863 N NH2 . ARG D 2 10  ? -46.857 23.822  -20.061 1.00 108.83 ? 146 ARG D NH2 1 
ATOM 3864 N N   . LYS D 2 11  ? -49.439 22.337  -28.501 1.00 90.51  ? 147 LYS D N   1 
ATOM 3865 C CA  . LYS D 2 11  ? -50.360 22.822  -29.525 1.00 85.20  ? 147 LYS D CA  1 
ATOM 3866 C C   . LYS D 2 11  ? -51.351 21.737  -29.926 1.00 83.77  ? 147 LYS D C   1 
ATOM 3867 O O   . LYS D 2 11  ? -52.539 22.012  -30.130 1.00 86.04  ? 147 LYS D O   1 
ATOM 3868 C CB  . LYS D 2 11  ? -49.579 23.315  -30.743 1.00 90.35  ? 147 LYS D CB  1 
ATOM 3869 N N   . ALA D 2 12  ? -50.879 20.499  -30.042 1.00 83.06  ? 148 ALA D N   1 
ATOM 3870 C CA  . ALA D 2 12  ? -51.743 19.338  -30.236 1.00 78.55  ? 148 ALA D CA  1 
ATOM 3871 C C   . ALA D 2 12  ? -51.798 18.608  -28.899 1.00 79.07  ? 148 ALA D C   1 
ATOM 3872 O O   . ALA D 2 12  ? -50.981 17.734  -28.616 1.00 92.95  ? 148 ALA D O   1 
ATOM 3873 C CB  . ALA D 2 12  ? -51.223 18.443  -31.354 1.00 88.62  ? 148 ALA D CB  1 
ATOM 3874 N N   . LEU D 2 13  ? -52.763 18.985  -28.065 1.00 74.99  ? 149 LEU D N   1 
ATOM 3875 C CA  . LEU D 2 13  ? -52.895 18.395  -26.738 1.00 86.19  ? 149 LEU D CA  1 
ATOM 3876 C C   . LEU D 2 13  ? -54.225 18.778  -26.098 1.00 77.33  ? 149 LEU D C   1 
ATOM 3877 O O   . LEU D 2 13  ? -54.824 19.794  -26.451 1.00 81.74  ? 149 LEU D O   1 
ATOM 3878 C CB  . LEU D 2 13  ? -51.730 18.831  -25.843 1.00 79.97  ? 149 LEU D CB  1 
ATOM 3879 C CG  . LEU D 2 13  ? -51.191 17.797  -24.852 1.00 70.31  ? 149 LEU D CG  1 
ATOM 3880 C CD1 . LEU D 2 13  ? -51.194 16.410  -25.470 1.00 74.31  ? 149 LEU D CD1 1 
ATOM 3881 C CD2 . LEU D 2 13  ? -49.785 18.177  -24.419 1.00 77.42  ? 149 LEU D CD2 1 
# 
